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Exhibit 10.17    
  

DATA MANAGEMENT AND REPORTING

SERVICES AGREEMENT
  By and Between
  CLINFO SYSTEMS, LLC
  and
  AXONYX INCORPORATED
  Effective
Dates: January 2, 2001 through July 31, 2001 

CLINFO SYSTEMS, LLC

400 White Oakshade Road

New Canaan, CT 06840  

 Phone: (203) 762-9656  •  FAX: (203) 761-8681  •  Email:
info@clinfosys.com  

 
DATA MANAGEMENT SERVICES AGREEMENT  

	Name and address of CLINFO SYSTEMS, LLC contact;
	

Principal:	
 	

Heidi M. Patzelt
	

Title:	
 	

Managing Director
	

Address:	
 	

400 White Oakshade Road

New Canaan, Connecticut 06840
	

Telephone:	
 	

(203) 762-9656
	

FAX:	
 	

(203) 761-8981
	

Email:	
 	

hpatzelt@clinfosys.com
	

 Name and address of AXONYX INC. Contact:
	

Principal:	
 	

Robert G. Burford, Ph.D., F.A.C.A.
	

Title:	
 	

Vice President of Product Development
	

Address:	
 	

AXONYX Incorporated

825 Third Avenue, 40th Floor

New York, NY 10022
	

Telephone:	
 	

(212) 688-4770
	

FAX:	
 	

(212) 688-4843
	

Email:	
 	

rburford@home.com

2

   AXONYX INC. and CLINFO SYSTEMS, LLC hereby agree as follows:  

1.  Term  

    The term of this Agreement shall be for the period beginning on January 2, 2001 and ending on or before July 31, 2001, unless terminated sooner
as provided for herein. 

2.  Scope of Work  

    CLINFO SYSTEMS, LLC shall perform the Data Management and Reporting services for AXONYX INC., as described in Exhibit 1 (the "SERVICES"),
attached hereto and made fully a part hereof. 

3.  Compensation  

    In consideration for the SERVICES, AXONYX INC. shall pay CLINFO SYSTEMS, LLC a professional fee in the amount and on the terms specified in
Exhibit 2 (the "FEE") attached hereto and made fully a part hereof. The total amount payable pursuant to this Agreement (including any reimbursable expenses allowable under this Agreement) may
not exceed $190,000.00 without the prior written consent of AXONYX INC. 

4.  Representations of CLINFO SYSTEMS, LLC  

    CLINFO SYSTEMS, LLC represents that CLINFO SYSTEMS, LLC has the requisite education, expertise, experience and skill, to render the desired SERVICES and CLINFO
SYSTEMS, LLC shall perform the SERVICES in a competent and efficient manner. CLINFO SYSTEMS, LLC further represents that CLINFO SYSTEMS, LLC shall abide by all laws, rules and regulations that apply
to the performance of the SERVICES, including applicable requirements regarding equal employment
opportunity and the provisions of Executive Order 11246 and related rules and, when on AXONYX INC. premises, CLINFO SYSTEMS, LLC shall comply with AXONYX INC. policies with respect to
conduct of visitors. 

5.  Confidentiality  

    During the performance of the SERVICES contemplated by this Agreement, CLINFO SYSTEMS, LLC may acquire certain Confidential, Proprietary, and/or Trade Secret
information of AXONYX INC. ("CONFIDENTIAL INFORMATION"). CLINFO SYSTEMS, LLC shall neither use nor disclose such CONFIDENTIAL INFORMATION for any purpose other than as is specifically allowed
by this Agreement. 

    CLINFO
SYSTEMS, LLC shall disclose such CONFIDENTIAL INFORMATION only to such of its employees as may reasonably be required to assist CLINFO SYSTEMS, LLC in the performance of this
AGREEMENT. In the event of such disclosure, CLINFO SYSTEMS, LLC shall advise its employees of the confidential nature of the information and shall instruct them to take all necessary and reasonable
precautions to prevent the unauthorized use or disclosure thereof. Each of CLINFO SYSTEMS, LLC's employees, consultants, and contractors execute a CLINFO SYSTEMS, LLC Confidentiality Agreement binding
them to uphold any Confidentiality Agreement entered into by CLINFO SYSTEMS, LLC. 

    CLINFO
SYSTEMS, LLC shall not disclose to others, without AXONYX INC. consent, the fact that CLINFO SYSTEMS, LLC is acting on behalf of AXONYX INC. and CLINFO SYSTEMS,
LLC shall not publish on the subject of this relationship without first providing AXONYX INC. with the opportunity to review and offer reasonable objection to the contemplated publication. 

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    Upon the expiration or termination of this Agreement, CLINFO SYSTEMS, LLC shall return to AXONYX INC. all tangible forms of CONFIDENTIAL INFORMATION, including any and all
copies and/or derivatives of CONFIDENTIAL INFORMATION made by CLINFO SYSTEMS, LLC (or CLINFO SYSTEMS, LLC's employees), as well as any writings, drawings, specifications, manuals or other printed
material made by CLINFO SYSTEMS, LLC (or CLINFO SYSTEMS, LLC's employees) and based on, or derived from, CONFIDENTIAL INFORMATION. 

    The
obligations set forth in this Article 5, including the obligations of confidentiality and non-use, shall be continuing and shall survive the expiration or
termination of this Agreement. 

6.  Conflicts of Interest  

    CLINFO SYSTEMS, LLC hereby warrants and affirms that it has advised AXONYX INC. in writing prior to the date of signing this Agreement, of any
relationship with any third parties, including competitors of AXONYX INC., which would present a conflict of interest with the SERVICES or which would prevent CLINFO SYSTEMS, LLC from
performing the SERVICES contemplated by this Agreement. CLINFO SYSTEMS, LLC further warrants and affirms that CLINFO SYSTEMS, LLC shall advise AXONYX INC. of any such relationships that might
arise during the term of this Agreement. In such event, AXONYX INC. shall have the option to terminate this Agreement without further liability to CLINFO SYSTEMS, LLC other than the obligations
to pay for SERVICES actually rendered as of the date of such termination. 

7.  Independent Contractor  

    The parties hereto agree that CLINFO SYSTEMS, LLC is being retained and shall perform as an "Independent Contractor" and CLINFO SYSTEMS, LLC and any employees
of CLINFO SYSTEMS, LLC performing SERVICES shall not be employees of AXONYX INC. The means, methods and manner in which SERVICES are rendered by CLINFO SYSTEMS, LLC shall be within CLINFO
SYSTEMS, LLC's sole control and discretion. 

    Nothing
contained in this Agreement shall be construed as making the parties joint ventures or as granting to either party the authority to bind or contract any obligations in the
name of or on the account of the other party or to make any representations, guarantees or warranties on behalf of the other party. 

    AXONYX INC.
shall not be responsible for CLINFO SYSTEMS, LLC's acts or the acts of its employees while performing the SERVICES whether on AXONYX INC. premises or
elsewhere. 

8.  Tax Reporting and Payment  

    CLINFO SYSTEMS, LLC further acknowledges and agrees that they shall be solely responsible for paying the appropriate amount of all federal, state and local
taxes with respect to all compensation paid to CLINFO SYSTEMS, LLC pursuant to this Agreement, and that AXONYX INC. shall have no responsibility whatsoever for withholding or paying any such
taxes for or on behalf of CLINFO SYSTEMS, LLC. CLINFO SYSTEMS, LLC further agrees to indemnify and hold AXONYX INC. harmless from and against any and all damages, losses, expenses, or penalties
arising from or in connection with any claim brought by a federal, state or local taxing authority with regard to CLINFO SYSTEMS, LLC's failure to pay required taxes or failure to file required forms
with regard to compensation paid to CLINFO SYSTEMS, LLC by AXONYX INC. pursuant to this Agreement. 

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9.  Insurance  

    CLINFO SYSTEMS, LLC acknowledges and agrees that AXONYX INC. does not and will not maintain or procure any worker's compensation insurance for or on
behalf of CLINFO SYSTEMS, LLC or CLINFO SYSTEMS, LLC's employees. 

10. Ownership of Developments  

    All written materials and other works which are directly related to the current project and which may be subject to patent or copyright that are made,
conceived or written by CLINFO SYSTEMS, LLC or CLINFO SYSTEMS, LLC's employees during the term of this Agreement, and for ninety (90) days after it expires, and which are based upon the
SERVICES performed by CLINFO SYSTEMS, LLC for AXONYX INC. ("DEVELOPMENTS") shall become AXONYX INC. property. CLINFO SYSTEMS, LLC agrees to hold all DEVELOPMENTS confidential in
accordance with Article 4 of this Agreement. 

11. Disclosure and Transfer of DEVELOPMENTS  

    CLINFO SYSTEMS, LLC shall disclose promptly to AXONYX INC. each DEVELOPMENT and, upon AXONYX INC. request and at AXONYX INC. expense,
CLINFO SYSTEMS, LLC shall assist AXONYX INC., or anyone AXONYX INC. designates, in filing patent or copyright applications in any country in the world. Each copyrightable work, to the
extent permitted by law, shall be considered a work made for hire and the authorship and copyright of the work shall be in AXONYX INC.'s name. CLINFO SYSTEMS, LLC shall execute all papers and
do all things which may be necessary or advisable, in the opinion of AXONYX INC., to prosecute such patent or copyright applications and to vest in AXONYX INC., or its designee, all the
right, title and interest in and to the DEVELOPMENTS. 

12. Disclosures to AXONYX INC.  

    If during the term of this Agreement, CLINFO SYSTEMS, LLC discloses any copyrightable works, to AXONYX INC. which were conceived or written prior to
this Agreement or which are not based upon the SERVICES performed by CLINFO SYSTEMS, LLC for AXONYX INC. under this Agreement,
AXONYX INC. shall have no liability to CLINFO SYSTEMS, LLC because of its use of such works, except liability for infringement of any valid copyright now or hereafter issued thereon. 

13. Liability  

    In the event of an actual breach by CLINFO SYSTEMS, LLC of any of the terms of this Agreement, with the exception of Articles 5, 10 and 11, AXONYX INC.
and its successors, officers, directors, agents and employees agree to indemnify, defend, and hold harmless from any and all actions, causes of action, claims, demand, cost, liabilities, expenses and
damages in excess of the fees paid to CLINFOSYS, LLC by AXONYX INC. Furthermore, CLINFO SYSTEMS, LLC shall have no liability to AXONYX INC. for consequential, punitive, and speculative
damages or lost profits resulting because of such a breach. 

14. Termination  

    In the event that a party hereto shall commit a material breach of this Agreement, the other party hereto shall have the right to terminate this Agreement
immediately. 

    AXONYX INC.
may terminate this Agreement at any time by giving CLINFO SYSTEMS, LLC thirty (30) days written notice of such termination. In such event, AXONYX INC.
shall pay CLINFO SYSTEMS, LLC for SERVICES performed by CLINFO SYSTEMS, LLC pursuant to this Agreement 

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as of the effective date of such notice. CLINFO SYSTEMS, LLC shall reimburse AXONYX INC. any and all moneys received by CLINFO SYSTEMS, LLC from AXONYX INC. which are in excess of the
money earned by CLINFO SYSTEMS, LLC as of the effective date of such notice. 

15. Miscellaneous Provisions  

 15.1 Assignability  

     No assignment by CLINFO SYSTEMS, LLC of this Agreement or any of its rights, duties or obligations hereunder, shall be binding on AXONYX INC. without
AXONYX INC.'s prior written consent. 

 15.2 Complete Agreement  

     This Agreement supersedes all prior Agreements and understandings between the parties related to the subject matter of this Agreement. 

 15.3 Amendment  

     This Agreement may not be altered, changed or amended except when written and signed by each of the parties hereto. 

 15.4 Survival  

     The provisions of Articles 5, 10 and 11 of this Agreement shall survive the termination of this Agreement. 

 15.5 Severability  

     In the event that any provision of this Agreement is held illegal or invalid for any reason, such provision shall not affect the remaining parts of this
Agreement, but this Agreement shall be construed and enforced as if that illegal and invalid provision had never been inserted herein. 

 15.6 Extraordinary Relief  

     In the event of the actual or threatened breach by CLINFO SYSTEMS, LLC of any of the terms of Articles 5, 10 and 11, AXONYX INC. shall have the right to
specific performance and injunctive relief. The rights granted by this paragraph are in addition to all other remedies and rights available at law or in equity. 

 15.7 Choice Of Law  

     This Agreement shall be construed according to the laws of Connecticut for contracts made within that state. 

 15.8 Attorney Fees Provision  

     In any litigation, arbitration, or other proceeding by which one party either seeks to enforce its rights under this Agreement (whether in contract, tort, or
both) or seeks a declaration of any rights or obligations under this Agreement, the prevailing party shall be awarded its reasonable attorney fees, and costs and expenses incurred. 

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 15.9 Counterpart Originals.  

     This Agreement may be executed in any number of counterparts, each of which, when executed, shall be deemed to be an original and all of which together shall
constitute one and the same document. 

 15.10 Representation on Authority of Parties/Signatories  

     Each person signing this Agreement represents and warrants that he or she is duly authorized and has legal capacity to execute and deliver this Agreement. Each
party represents and warrants to the other that the execution and delivery of the Agreement and the performance of such party's obligations hereunder have been duly authorized and that the Agreement
is a valid and legal agreement binding on such party and enforceable in accordance with its terms. 

    IN
WITNESS WHEREOF, the parties hereto have executed, or have caused their duly authorized representatives to execute, this Agreement as of January 2, 2001. 

	CLINFO SYSTEMS, LLC	 	AXONYX INC.
	
By:	
 	

/s/ HEIDI M. PATZELT   
 Heidi M. Patzelt	
 	

By:	
 	

/s/ ROBERT G. BURFORD, PH.D.   
 Robert G. Burford, Ph.D.
	

Title:	
 	

Managing Director	
 	

Title:	
 	

Vice President Product Development
	

Date:	
 	

1/2/01	
 	

Date:	
 	

1/2/01

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   EXHIBIT 1—SERVICES  

Preamble  

    AXONYX INC. has completed a multiple dose, placebo controlled clinical trial of Phenserine tartrate in thirty-two healthy human volunteers,
for which they require the data management and reporting services of CLINFO SYSTEMS, LLC. This study was conducted by Northwest Kinetics, LLC of Tacoma, Washington and clinically complete as of
September 25, 2000. The title of the study is 

"A double blind, randomized, sequential group, multiple oral dose study

of the safety, tolerance and anticholinesterase profile of

Phenserine tartrate in healthy human subjects."

Objective  

    The objective of this contract exhibit is to outline all of the CLINFO SYSTEMS, LLC's data management and reporting services required for this study. 

Assumptions  

A.  CLINFO SYSTEMS, LLC  

	1.
	This
quote is based upon a protocol by the same name dated April 3, 2000 and made a part of this agreement.

	2.
	CLINFO
SYSTEMS, LLC will have the full cooperation of AXONYX INC. in-house personnel who may have been involved in the successful completion of this study.

	3.
	CLINFO
SYSTEMS, LLC shall not be responsible for profiling the Acetycholinesterase activity or pharmacokinetics of this drug.

	4.
	CLINFO
SYSTEMS, LLC shall not be responsible for the collection, maintenance, governmental filing or archival of regulatory documents associated with the clinical conduct or future
regulatory submissions of this study.

	5.
	CLINFO
SYSTEMS, LLC shall have the responsibilities detailed below which are confined to the collection, management, analysis and reporting of the data in this clinical trial.

	6.
	Any
sub-contractors selected by CLINFO SYSTEMS, LLC (with approval from AXONYX INC.) shall perform their assigned tasks in a timely manner, on budget and in full
compliance with GCP and AXONYX INC. SOP requirements.

	7.
	CLINFO
SYSTEMS, LLC will receive original CRFs provided to AXONYX INC. by Northwest Kinetics, LLC, and image these documents for processing and electronic archival. 

B.  AXONYX INC.  

	1.
	AXONYX INC.
shall be responsible for conveying information to CLINFO SYSTEMS, LLC in a timely manner regarding any site conduct or monitoring issues known to have occurred
during the trial.

	2.
	AXONYX INC.
shall be responsible for guaranteeing that source document verification of the data recorded on the Case Report Forms and site monitoring services were performed
by qualified clinical research associates (CRAs) as per the code of federal regulations CFR 21 governing these activities.

	3.
	AXONYX INC.
will be responsible for the physical storage of the original CRFs. 

8

 

	4.
	AXONYX INC.
has the right to review the qualifications of all CLINFO SYSTEMS, LLC personnel assigned to this project and to be informed of any changes in said assignments
during the course of the project. 

C.  Subjects: 32 to complete 

D.  Sites: 1 

E.  Treatment Duration: 8 days per subject 

F.  Case Report Forms

	1.
	11
unique Case Report Forms (20 unique data collection pages)

	2.
	@
60 pages/subject to be databased

	3.
	@
1,920 total CRF pages to be processed at least once for the study

	4.
	Assume
40% require scrubbing/clarification, therefore @ 2,680 pages to process 

H.  Last Data Resolution to be sent to CLINFO SYSTEMS, LLC: April 1, 2001 

Services to be provided by CLINFO SYSTEMS, LLC  

	1.
	Database
design and validation.

	2.
	Development
and implementation of a Data Management Plan approved by AXONYX, INC.

	3.
	Scanning,
filing, and electronic entry of final CRF data into both a Microsoft Access V. 5.0 database and a SAS V. 8 data library constructed for this study.

	4.
	Performance
of CLINFO SYSTEMS, LLC Quality Assurance (QA) and Quality Control (QC) routines. QA/QC reports are to include programming validation, error estimations, and consistency
and validity error checks used to clean the data and detect the presence of fraud.

	5.
	Unblinding
the study database after all patients' data have been verified, all quality assurance procedures have been executed, and all eligibility/evaluability determinations have
been made.

	6.
	Statistical
programming, analysis and reporting.

	7.
	Integrated
Clinical/Statistical study report writing.

	8.
	Archival
and indexing of all final CRF images onto CD-ROM. Distribution of one copy to Northwest Kinetics, LLC and two copies to the sponsor. CLINFO SYSTEMS, LLC shall
retain one copy for a period of five years for potential FDA inspection use.

	9.
	Archival
of the statistical report, the clinical report, all associated summary tables and data listings, the incremental and locked database (including audit trail), all SAS
programs used to analyze the data, all QA/QC reports and all general data related correspondence on CD-ROM. 

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EXHIBIT 2—FEES  

A. Estimated Costs from January 2, 2001 through July 31, 2001—@ 7 mos.  

	 
	 	Service(s)
	 	Estimated

Work Units
	 	Cost Per Unit
	 	Estimated

Total Cost

	

1.	
 	

Data Management Plan development and maintenance	
 	

40 Sr. DM total hours	
 	
$	

78/hour	
 	
$	

3,120
	

2.	
 	

Database creation, validation, and maintenance	
 	

104 Sr. DM/Pgm total hours	
 	
$	

78/hour	
 	
$	

8,112
	

3.	
 	

Data acquisition, processing, cleaning (including audit trail), and finalization	
 	

2,680 CRF pages	
 	
$	

21.68/page	
 	
$	

58,102
	

4.	
 	

Management of electronic transfer and storage of all laboratory results	
 	

24 Pgm total hours	
 	
$	

96/hour	
 	
$	

2,304
	

5.	
 	

Statistical Analysis:

—Planning

—Programming and validation,

—Generation of tables and listings

—First draft statistical report generation

—Statistical report review, revision and approval	
 	

300 Sr. Stat/Pgm total hours	
 	
$	

180/hour	
 	
$	

54,000
	

6.	
 	

Integrated Clinical/Statistical Study Report:

—Planning

—First draft Report Generation

—Clinical Report review, revision and approval	
 	

320 Sr. Medical Writer total hours	
 	
$	

150/hour	
 	
$	

48,000
	

7.	
 	

Archival and transfer of reports, data, SAS programs, and QA/QC documentation in both hardcopy and electronic format, including but not limited to

—CRF image storage on CD-ROM

—Both incremental and locked databases, as well as audit trail records on CD-ROM

—Patient data listings

—Descriptive summary tables

—General data management and report correspondence, along with the final Data Management and Statistical Analysis Plans on CD-ROM

—Final Statistical Analysis

—Final Clinical Report	
 	

80 DC hours total plus materials	
 	
$	

40/hour	
 	
$	

3,200
	

8.	
 	

Data and Reporting Project Management	
 	

6 Sr. DM hours/month (7 months)	
 	
$	

78/hour	
 	
$	

3,276
	

 	
 	
TOTAL ESTIMATE	
 	

 	
 	
 	

 	
 	
$	

180,114

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B. Payment Schedule  

    The total charges for services as defined in Exhibit 1, plus AXONYX INC pre-approved reimbursable expenses, are not to exceed $190,000.000
U.S., without the prior written consent of AXONYX INC. 

    Expenses
are to be submitted and paid to CLINFO SYSTEMS, LLC on a monthly basis. 

    Fees
for data management and reporting services are to be paid to CLINFO SYSTEMS, LLC according to the following payment schedule: 

	1.
	Within
30 days of signing this contract, a total of $45,000.00 will be due to CLINFO SYSTEMS, LLC.This amount shall cover all start-up costs and be
non-refundable.

	2.
	Beginning
with February 28, 2001, and ending on June 30, 2001, monthly invoices of $23,400.00 for ongoing services will be submitted. Payment to CLINFO SYSTEMS, LLC is
due within 30 days of receipt of an invoice.

	3.
	The
final Payment of approximately 10% of the contracted amount for services, i.e., $18,114.00 will be made upon satisfactory delivery to AXONYX, INC. of all items listed
under Exhibit 2—Table A—Service # 7. 

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QuickLinks

Exhibit 10.17<PAGE>

===============================================================================

                                                                   EXHIBIT 10.1

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                             DISTRIBUTION AGREEMENT

                                  BY AND AMONG

                                PLC SYSTEMS INC.,

                            PLC MEDICAL SYSTEMS, INC.

                                       AND

                            EDWARDS LIFESCIENCES LLC

                                      DATED

                                 JANUARY 9, 2001

===============================================================================

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<S>                                                                                             <C>

ARTICLE I Definitions..............................................................................1

ARTICLE II Appointment.............................................................................4

   SECTION 2.1.    Appointment.....................................................................4
   SECTION 2.2.    Competition.....................................................................4

ARTICLE III Obligations of Distributor.............................................................5

   SECTION 3.1.    General Obligations of Edwards..................................................5
   SECTION 3.2.    Costs and Expenses..............................................................5
   SECTION 3.3.    Sales and Marketing Option......................................................5

ARTICLE IV Obligations of PLC......................................................................6

   SECTION 4.1.    Transition Services.............................................................6
   SECTION 4.2.    Approvals.......................................................................6
   SECTION 4.3.    Labeling of Products............................................................6
   SECTION 4.4.    Clinical or Marketing Studies...................................................6
   SECTION 4.5.    Installation Services and Services Provided under Extended Service Agreements...6
   SECTUIB 4.6.    Warranty and Preventive Maintenance Services....................................7
   SECTION 4.7.    Recall of Products..............................................................7
   SECTION 4.8.    Product Liability Insurance.....................................................7
   SECTION 4.9.    Costs and Expenses..............................................................8

ARTICLE V Sales and Marketing......................................................................8

   SECTION 5.1.    Marketing Plan..................................................................8
   SECTION 5.2.    Sales Plan......................................................................8
   SECTION 5.3.    Sales Material and Literature...................................................8
   SECTION 5.4.    Training and Retention of Sales Personnel.......................................8
   SECTION 5.5.    Performance Record of Sales Personnel...........................................9

                                       i

<PAGE>

<CAPTION>
<S>                                                                                            <C>

ARTICLE VI Purchase Arrangements.................................................................. 9

   SECTION 6.1.    Purchase Forecasts for Products................................................ 9
   SECTION 6.2.    Purchaser Orders; No Minimum Product Quantities................................ 9
   SECTION 6.3.    Placement of Orders............................................................10

ARTICLE VII Pricing, Payment, Shipping............................................................10

   SECTION 7.1.    TMR Disposable Kits............................................................10
   SECTION 7.2.    HL-1 Laser Systems.............................................................11
   SECTION 7.3.    HL-2 Laser Systems.............................................................11
   SECTION 7.4.    Product Accessories............................................................12
   SECTION 7.5.    Shipping.......................................................................12
   SECTION 7.6.    Payment........................................................................12

ARTICLE VIII Term and Termination; Annual Meeting.................................................12

   SECTION 8.1.    Term and Renewal...............................................................12
   SECTION 8.2.    Immediate Termination..........................................................13
   SECTION 8.3.    Annual Meeting.................................................................13

ARTICLE IX Warranties and Indemnification.........................................................13

   SECTION 9.1.    Warranties.....................................................................13
   SECTION 9.2.    Indemnification by PLC.........................................................13
   SECTION 9.3.    Indemnification by Edwards.....................................................14
   SECTION 9.4.    Indemnification Procedures.....................................................14

ARTICLE X Intellectual Property Rights and Confidentiality........................................15

   SECTION 10.1.   Trademarks.....................................................................15
   SECTION 10.2.   Confidential Information.......................................................15

ARTICLE XI MISCELLANEOUS..........................................................................16

   SECTION 11.1.   Relationship...................................................................16
   SECTION 11.2.   No Conflict....................................................................16
   SECTION 11.3.   Governing Law..................................................................16
   SECTION 11.4.   Escalation.....................................................................17

                                       ii

<PAGE>

<CAPTION>
<S>                                                                                            <C>

   SECTION 11.5.   Jurisdiction and Consent to Service............................................17
   SECTION 11.6.   Notices........................................................................18
   SECTION 11.7.   Interpretation.................................................................19
   SECTION 11.8.   Severability...................................................................19
   SECTION 11.9.   Counterparts...................................................................19
   SECTION 11.10.  Entire Agreement; No Third Party Beneficiaries.................................19
   SECTION 11.11.  Amendments and Modifications; Waivers and Extensions...........................20
   SECTION 11.12.  Assignment.....................................................................20
   SECTION 11.13.  Exhibits.......................................................................20
   SECTION 11.14.  Expenses.......................................................................20
   SECTION 11.15.  No Consequential or Punitive Damages...........................................21
</TABLE>

EXHIBITS AND SCHEDULES

   Exhibit A      Description of Products
   Schedule 2.1   Distributors
   Schedule 3.3   Sales Personnel
   Schedule 4.1   Transition Services
   Schedule 4.5   Installation Services and Services Relating to Extended
                  Service Agreements
   Schedule 4.6   Warranty and  Preventive Maintenance Services
   Schedule 4.8   Product Liability Insurance
   Schedule 5.1   Marketing Plan
   Schedule 5.2   Sales Plan
   Schedule 7.3   HL-2 Laser System Customers
   Schedule 7.4   Product Accessories

                                       iii

<PAGE>

                             DISTRIBUTION AGREEMENT

         DISTRIBUTION AGREEMENT, dated as of January 9, 2001 this "Agreement"),
by and among Edwards Lifesciences LLC, a Delaware corporation ("Edwards"), PLC
Systems Inc., a Yukon Territory corporation ("PLC Parent"), and PLC Medical
Systems, Inc., a Delaware corporation ("PLC"), which is a wholly owned
subsidiary of PLC Parent.

         WHEREAS, PLC has developed a carbon dioxide laser system and related
accessories described in EXHIBIT A hereto (as set forth in Exhibit A, the
"Products"), and desires that the sale and use of the Products be actively
promoted in the fifty states of the United States of America and the District of
Columbia (the "Territory");

         WHEREAS, Edwards is a company in the medical devices field with
experience and expertise in the commercialization and distribution of medical
devices;

         WHEREAS, PLC desires to engage Edwards to purchase, resell and
distribute the Products in the Territory; and

         WHEREAS, Edwards desires to obtain rights to purchase, resell and
distribute the Products in the Territory;

         NOW, THEREFORE, in consideration of the mutual agreements and covenants
contained herein and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, and intending to be legally bound
hereby, the parties hereto agree as follows:

                                   ARTICLE I

                                  DEFINITIONS

         As used in this Agreement, the following terms shall have the following
meanings:

         "Agreement" shall have the meaning set forth in the Recitals.

         "Automatic Renewal Threshold" shall have the meaning set forth in
Section 8.1.

         "Average End User Price" shall have the meaning set forth in Section
7.1.

<PAGE>

         "Damages" shall have the meaning set forth in Section 9.2.

         "DBMR" shall have the meaning set forth in Section 2.2.

         "Dispute" shall have the meaning set forth in Section 11.4.

         "Edwards" shall have the meaning set forth in the Recitals.

         "Edwards Facility" shall have the meaning set forth in Section 7.5.

         "Effective Date" shall have the meaning set forth in Section 8.1.

         "Escalation Notice" shall have the meaning set forth in Section 11.4.

         "Estimated End User Price" shall have the meaning set forth in Section
7.1.

         "ETL" shall have the meaning set forth in Section 4.2.

         "FDA" shall have the meaning set forth in Section 4.2.

         "HL-1 Laser System" shall have the meaning set forth in EXHIBIT A.

         "HL-2 Laser System" shall have the meaning set forth in EXHIBIT A.

         "HL-2 Purchase Price" shall have the meaning set forth in Section 7.3.

         "Indemnified Party" shall have the meaning set forth in Section 9.3.

         "Indemnifying Party" shall have the meaning set forth in Section 9.3.

         "Initial Term" shall have the meaning set forth in Section 8.1.

         "PLC" shall have the meaning set forth in the Recitals.

         "PLC Parent" shall have the meaning set forth in the Recitals.

                                      -2-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

         "Products" shall have the meaning set forth in the Recitals.

         "Sales and Marketing Option" shall have the meaning set forth in
Section 3.3.

         "Scheduled Employees" shall have the meaning set forth in Section 3.3

         "Services" shall have the meaning set forth in Section 4.5.

         "Territory" shall have the meaning set forth in the Recitals.

         "TMR Disposable Kit" shall have the meaning set forth in EXHIBIT A.

         "Transaction Agreements" shall have the meaning set forth in Section
11.10.

         "Usage Premium" shall mean, with respect to each contract pursuant to
which an HL-1 Laser System or HL-2 Laser System is sold, the dollar amount by
which the per-usage charge set forth in such contract exceeds the TMR Disposable
Kit price set forth in such contract or if the TMR Disposable Kit price is not
explicitly stated in such contract, the list price of a TMR Disposable Kit at
the time the contract was entered into. In addition, Usage Premium shall also
include the amount of any additional payments related exclusively to the use of
the applicable Laser System, including, but not limited to, rental or lease
payments.

         "Warehouse Retesting" shall mean retesting an HL-2 Laser System to its
original factory specifications due to the fact that it has been warehoused by
Edwards for longer than the Warehouse Life.

         "Warehouse Life" shall mean [**], unless PLC reasonably determines, at
any time during the term of this Agreement, that such period may be extended,
but in no event shall such period be extended to more than [**]; provided,
however that PLC shall provide Edwards with the data upon which it makes the
determination to extend or maintain the Warehouse Life.

                                      -3-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

         "Warranty Period" shall mean in the event (a) an HL-2 Laser System is
shipped before the expiration of the Warehouse Life, the period from the date of
installation until the [**] anniversary of such installation, but not to exceed
[**] from the date of shipment to the end user; (b) an HL-2 Laser System is
shipped after the expiration of the Warehouse Life and PLC has requested that
such HL-2 Laser System be Warehouse Retested and Edwards ships without such
Warehouse Retesting, the period from the date of sale to Edwards until the date
which is [**] plus the Warehouse Life; (c) a proposed shipment of an HL-2 Laser
System would occur after the expiration of the Warehouse Life, and Edwards and
PLC agree to the Warehouse Retesting of such HL-2 Laser System, the period from
the date of installation until the [**] anniversary of such installation, but
not to exceed [**] from the date of shipment to the end user; and (d) a proposed
shipment of an HL-2 Laser System would occur after the expiration of the
Warehouse Life, and Edwards and PLC agree that Warehouse Retesting of such HL-2
Laser System is not necessary, the period from the date of installation until
the [**] anniversary of such installation, but not to exceed [**] from the date
of shipment to the end user.

                                   ARTICLE II

                                   APPOINTMENT

         SECTION 2.1. APPOINTMENT. Subject to the terms and conditions
contained in this Agreement, PLC hereby appoints Edwards as PLC's exclusive
independent distributor of the Products in the Territory. Edwards may not
appoint a secondary or sub-distributor to sell the Products without PLC's
prior written consent, other than those set forth on Schedule 2.1. PLC shall
not appoint any other agents, representatives, or distributors for the
purpose of selling the Products in the Territory.

         SECTION 2.2. COMPETITION. Edwards shall not sell any devices in the
Territory which directly compete with the Products in the field of myocardial
revascularization either intraoperative or percutaneous that uses a
device-based channeling means ("DBMR") during the term of this Agreement.
Edwards may market and sell medical devices, including, without limitation,
products that may be used in connection with revascularization of the heart,
as long as such medical devices are not within the field of DBMR and all
other medical devices which it is selling as of the date hereof. Edwards does
not currently sell any devices in the field of DBMR.

                                      -4-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                  ARTICLE III

                          OBLIGATIONS OF DISTRIBUTOR

         SECTION 3.1. GENERAL OBLIGATIONS OF EDWARDS. Edwards shall use
commercially reasonable efforts to distribute and sell the Products in the
Territory including, without limitation, the following:

         Promote the sale and use of Products in the Territory;

         Provide customer service, including responding to customer inquiries
and requests for quotes on Product pricing; and

         Provide invoices to customers and manage accounts receivable and
collection responsibilities for sales by Edwards of the Products.

         SECTION 3.2. COSTS AND EXPENSES. Edwards shall bear all the costs
and expenses associated with its obligations set forth in this Agreement.

         SECTION 3.3. SALES AND MARKETING OPTION. Edwards shall have the
option (the "Sales and Marketing Option") which must be exercised, if at all,
upon [**] prior written notice to PLC given during or before the [**] period
following the [**]anniversary of the date hereof, to assume full sales and
marketing responsibility for the Products in the Territory and to offer
employment, subject to Edwards' standard employment qualifications, with base
compensation, commission and benefits substantially competitive to those
provided by PLC immediately prior to such offer to each PLC employee set
forth on Schedule 3.3 (the "Scheduled Employees"), provided they meet the
performance criteria set forth on Schedule 3.3. Upon exercise of the Sales
and Marketing Option, PLC shall release performance reviews of the Scheduled
Employees to Edwards, subject to the waiver of each such employee. If such
Scheduled Employee refuses to waive access to his or her performance reviews,
such refusal shall constitute a rejection of an offer of employment from
Edwards and Edwards shall have no further obligations with respect to such
employee and PLC shall be responsible for any severance pay pursuant to the
last sentence of this section. If Edwards chooses not to offer employment to
any Scheduled Employee that meets the performance criteria set forth on
Schedule 3.3 and Edwards' standard employment qualifications, Edwards shall
pay to PLC the amount on Schedule 3.3 per such employee. In the event a
Scheduled Employee rejects the employment offer by Edwards, PLC shall be
responsible for severance pay to such employee, if any, pursuant to PLC's
then existing severance policy, if any.

                                      -5-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                  ARTICLE IV

                              OBLIGATIONS OF PLC

         SECTION 4.1. TRANSITION SERVICES. PLC shall and PLC Parent shall
cause PLC to provide to Edwards [**] the transition services set forth on
Schedule 4.1 for a period of up to [**] from the Effective Date which
services Edwards may terminate in whole or in part at any time prior to the
expiration of such [**]period.

         SECTION 4.2. APPROVALS. PLC shall and PLC Parent shall cause PLC to
use commercially reasonable efforts to obtain and maintain all approvals and
clearances required with respect to the sale of the Products in the
Territory, including, without limitation, approvals from the Food and Drug
Administration (the "FDA") and the Electrical Testing Laboratory ("ETL").

         SECTION 4.3. LABELING OF PRODUCTS. PLC shall and PLC Parent shall
cause PLC to provide and to assume regulatory responsibility for all finished
Product and Product-related labeling, including all sales and marketing
literature, such that it complies with all applicable laws and regulations in
the Territory during the term of this Agreement. All labeling for the
Products shall include the statement "Distributed by Edwards Lifesciences
LLC, Manufactured by PLC Medical Systems, Inc."

         SECTION 4.4. CLINICAL OR MARKETING STUDIES. PLC shall and PLC Parent
shall cause PLC to use commercially reasonable efforts to conduct any
clinical study with respect to the Products required by the FDA or other
governmental agencies to sell or market the Products in the Territory. All
other clinical or marketing studies with respect to the Products that are
conducted within the Territory will be approved, funded, and conducted on
terms and conditions mutually agreed to by PLC and Edwards.

         SECTION 4.5. INSTALLATION SERVICES AND SERVICES PROVIDED UNDER
EXTENDED SERVICE AGREEMENTS. PLC shall and PLC Parent shall cause PLC to
provide the services and technical support relating to the Products as set
forth on Schedule 4.5 (the "Schedule 4.5 Services"). PLC shall retain all
service fees and revenues that it receives from end users for providing the
Schedule 4.5 Services, PROVIDED that PLC shall pay to Edwards a commission of
[**]% of all such fees and revenues. If and to the extent that PLC fails to
perform its obligation in the first sentence of this Section 4.5, Edwards may
provide those Schedule 4.5 Services or contract with a third party to provide
those Schedule 4.5 Services. In such event, Edwards shall keep all service
fees and revenues resulting therefrom and PLC shall train the personnel (at a
rate of $[**] per day)

                                      -6-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

performing such Schedule 4.5 Services (whether employed by Edwards or a third
party) and provide factory support, including, without limitation, spare parts,
technical troubleshooting, and processing product returns. PLC shall also
provide Edwards with monthly reports with respect to Product returns and
complaints. Edwards shall log in any Products returned by customers to Edwards
and return such Products to PLC. If an HL-2 Laser System is installed and the
price to be paid by the end user for such installation is less than $[**] per
day, PLC shall install such HL-2 Laser System and Edwards shall pay PLC the
difference between $[**] and the amount to be paid by the end user per day for
such installation, but in no event shall Edwards' payment exceed $[**] per
installation.

         SECTION 4.6. WARRANTY AND PREVENTIVE MAINTENANCE SERVICES. PLC shall
and PLC Parent shall cause PLC to provide all warranty and two scheduled
preventive maintenance services on all HL-2 Laser Systems as set forth on
Schedule 4.6 during the Warranty Period. Edwards shall reimburse PLC for the
costs set forth on Schedule 4.6 incurred by PLC in the performance of its
obligation in the prior sentence during the Warranty Period, but in no event
shall such reimbursement exceed $[**] per HL-2 Laser System. In the event PLC
is required to conduct Warehouse Retesting on an HL-2 Laser System, Edwards
shall reimburse PLC $[**] per such HL-2 Laser System, upon completion of
Warehouse Retesting.

         SECTION 4.7. RECALL OF PRODUCTS. In the event of a recall of any of
the Products, PLC shall and PLC Parent shall cause PLC to bear all costs and
expenses of such recall, including, without limitation, expenses or
obligations to third parties, the cost of notifying customers and end users,
and costs associated with the shipment of recalled Products from customers to
PLC. Edwards shall cooperate with PLC in effecting any recall of the Products
sold by Edwards by producing customer lists and assisting with the
notification of customers and end users of the recalled Products.

         SECTION 4.8. PRODUCT LIABILITY INSURANCE. Set forth on Schedule 4.8
is a copy of PLC's product liability insurance policy which is in full force
and effect. PLC shall and PLC Parent shall cause PLC to obtain and keep in
force during the term of this Agreement a product liability insurance policy
in an amount not less than $10,000,000 in a form reasonably acceptable to
Edwards. During the term of this Agreement and for a period of [**] following
the expiration or termination of this Agreement, such insurance policy shall
evidence Edwards and all of its affiliates as additional insured entities and
shall provide for written notification to Edwards by the insurer not less
than 30 days prior to cancellation, expiration or modification. PLC shall and
PLC Parent shall cause PLC to provide a certificate of insurance evidencing
compliance with this Section 4.8 to Edwards within 30 days of the date hereof.

                                      -7-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

         SECTION 4.9. COSTS AND EXPENSES. PLC shall and PLC Parent shall
cause PLC to bear all the costs and expenses associated with PLC's
obligations set forth in this Agreement.

                                  ARTICLE V

                             SALES AND MARKETING

         SECTION 5.1. MARKETING PLAN. PLC and Edwards shall jointly execute
the marketing plan for the Products set forth in Schedule 5.1 and fund such
plan based on the percentages set forth on such schedule during the first six
months of the term of this Agreement. During such period, PLC and Edwards
shall jointly develop a marketing plan for the Products for the next six
months and PLC shall provide [**]% of the funding for such plan and Edwards
shall provide the remaining [**]% of the funding. PLC and Edwards shall
continue to jointly develop a marketing plan for the Products and provide
funding for such plan according to mutually agreeable allocations until such
time as Edwards exercises the Sales and Marketing Option.

         SECTION 5.2. SALES PLAN. Edwards and PLC agree to the sales plan set
forth on Schedule 5.2. Edwards shall reimburse any out-of-pocket costs for
travel incurred by PLC in connection with training Edwards' sales personnel
beyond the scope of the training requirements anticipated in Schedule 5.2.

         SECTION 5.3. SALES MATERIAL AND LITERATURE. PLC shall initially
provide all sales material and literature for the Products. PLC and Edwards
shall jointly develop any new literature. The costs and expenses associated
with developing and producing any new literature shall be paid jointly by PLC
and Edwards according to the funding percentages set forth in Section 5.1
until such time as Edwards exercises the Sales and Marketing Option. If
Edwards exercises such option, Edwards thereafter shall be solely responsible
for paying the cost of such literature. Nothing in this Section 5.3 shall
have any effects on PLC's obligations set forth in Section 4.3.

         SECTION 5.4. TRAINING AND RETENTION OF SALES PERSONNEL. PLC shall
provide products and sales training to all PLC and Edwards sales personnel
that are engaged in marketing and selling the Products in the Territory. PLC
shall use commercially reasonable efforts to retain the sales personnel set
forth on Schedule 3.3. During the term of this Agreement and for a period of
[**] after the termination or expiration of this Agreement, neither PLC
Parent nor PLC shall hire or solicit for

                                      -8-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

employment any of Edwards' personnel without the prior written consent of
Edwards. During the term of this Agreement and for a period of one year after
the termination or expiration of this Agreement, Edwards shall not hire or
solicit for employment any personnel of PLC Parent or PLC without the prior
written consent of PLC; PROVIDED, HOWEVER, that if Edwards exercises the Sales
and Marketing Option, the foregoing limitations shall be inapplicable to
personnel listed or otherwise referenced on Schedule 3.3.

         SECTION 5.5. PERFORMANCE RECORD OF SALES PERSONNEL. PLC shall keep
an accurate and complete record of the performance of all Scheduled
Employees, including the sales figures for each Scheduled Employee, and will
provide quarterly updates to Edwards of the sales figures for each territory.

                                  ARTICLE VI

                            PURCHASE ARRANGEMENTS

         SECTION 6.1. PURCHASE FORECASTS FOR PRODUCTS. PLC and Edwards shall
confer monthly and jointly produce a [**] forecast of the expected demand for
the Products until such time as Edwards exercises the Sales and Marketing
Option. After Edwards exercises such option, for the remaining term of the
Agreement, Edwards shall provide quarterly to PLC a [**]forecast of the
expected demand for the Products.

         SECTION 6.2. PURCHASER ORDERS; NO MINIMUM PRODUCT QUANTITIES.
Edwards shall submit a non-cancelable purchase order to PLC for TMR Disposal
Kits for the upcoming calendar quarter on the first day of the month
preceding such quarter except that until June 30, 2001, Edwards shall submit
non-cancelable purchase orders on a monthly basis for TMR Disposal Kits.
Until such time as Edwards exercises the Sales and Marketing Option, Edwards
shall submit non-cancelable purchase orders to PLC for HL-2 Laser Systems on
an as needed basis. If Edwards exercises such option, thereafter, Edwards
shall submit a non-cancelable purchase order to PLC for HL-2 Laser Systems
for the upcoming calendar quarter on the first day of the month preceding
such quarter. Notwithstanding its provision of demand forecasts for the
Products and anything else set forth herein, Edwards shall determine in its
sole discretion the quantity of Products it shall purchase and there shall be
no minimum purchase requirements for any Products. To the extent that the
terms of any purchase order and the terms of this Agreement conflict, the
terms of this Agreement shall control.

                                      -9-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

         SECTION 6.3. PLACEMENT OF ORDERS. All orders for Products submitted
by Edwards shall be initiated by written purchase orders sent to PLC which
shall specify the desired delivery date, location and method of
transportation for the Products included in such order. With respect to any
Product for which Edwards may submit purchase orders to PLC on an as needed
basis, Edwards agrees to promptly submit purchase orders to PLC after its
receipt of orders from its customers, but, in any event, shall submit
purchase orders to PLC within ten business days of its receipt of a customer
order. Quarterly purchase orders submitted to PLC by Edwards will indicate
the quantity of Products to be delivered for each month of the quarter,
provided, however, the quantity for any individual month shall in no case be
less than [**]% of the total to be delivered for the entire quarter. The
quantity for the quarter shall not exceed [**]% of the most recent forecasted
quantity for the quarter. PLC shall use commercially reasonable efforts to
deliver the Products on the agreed upon delivery dates set forth in accepted
purchase orders, but, in any event, shall make all deliveries within [**]
days of the agreed upon delivery dates set forth in accepted purchase orders.

                                 ARTICLE VII

                          PRICING, PAYMENT, SHIPPING

         SECTION 7.1. TMR DISPOSABLE KITS. (a) Edwards shall purchase the TMR
Disposable Kits from PLC at [**]% of the Average End User Price. If Edwards
exercises the Sales and Marketing Option, thereafter Edwards shall purchase
the TMR Disposable Kits from PLC at [**]% of the Average End User Price. The
"Average End User Price" shall mean the average of the actual sales price for
each TMR Disposable Kit sold during a calendar quarter. Edwards shall
calculate the Average End User Price and deliver such calculation to PLC
within [**] days after the end of each quarter.

         (b) PLC shall bill TMR Disposable Kits to Edwards on a preliminary
basis at [**]% of the Estimated End User Price before Edwards exercises the
Sales and Marketing Option and [**]% of the Estimated End User Price after
Edwards exercises such option. Through June 30, 2001, the "Estimated End User
Price" shall be $[**]. During subsequent quarters of the Agreement, the
"Estimated End User Price" shall be equal to the Average End User Price for the
most recent quarter that such data is available and calculable.

                                      -10-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

         (c) The difference between the preliminary amount billed during a
quarter using the Estimated End User Price and the actual amount owed using the
Average End User Price shall be credited to Edwards by PLC or paid by Edwards to
PLC, as the case may be, within [**] days of the date such Average End User
Price is determined. With respect to TMR Disposable Kits that PLC has sold prior
to the date of this Agreement to PLC customers using the HL-1 Laser System, but
as to which delivery has not yet been requested by the applicable customer, upon
such request for delivery PLC shall provide the requested TMR Disposable Kits to
Edwards [**], and Edwards shall provide such TMR Disposable Kits to the
applicable customer [**].

         (d) Within [**] days of the end of each calendar month, Edwards shall
provide to PLC a written report showing, for the month immediately preceding the
report, Edwards' sales of the Products, including the name of the customer, the
date of the shipment, the price of the Product and the allocation of the price
between Edwards and PLC. Edwards shall maintain for at least two years its
records, contracts and accounts relating to sales of the Products, and shall
permit examination thereof by authorized representatives of PLC at all
reasonable times.

         SECTION 7.2. HL-1 LASER SYSTEMS. Edwards shall deliver to PLC [**]%
of all Usage Premiums received in connection with the sale of TMR Disposable
Kits for use with, and service revenue related to, HL-1 Laser Systems.
Edwards shall deliver any and all monies received in connection with the
purchase of an HL-1 Laser System to PLC.

         SECTION 7.3. HL-2 LASER SYSTEMS. Subject to any adjustment provided
herein, Edwards shall purchase the HL-2 Laser Systems from PLC for $[**] per
unit, which amount includes warehousing fees at PLC's facility (the "HL-2
Purchase Price"). In addition, Edwards shall pay PLC [**]% of the amount the
HL-2 Laser System end user price exceeds the HL-2 Purchase Price for each
such HL-2 Laser System sold. Edwards shall retain the Usage Premiums it
receives from each HL-2 Laser System that is placed until the aggregate Usage
Premiums received with respect to such HL-2 Laser System equals the[**].
Thereafter, Edwards shall pay PLC [**]% of such Usage Premiums. PLC and
Edwards agree to periodically review in good faith the HL-2 Laser Purchase
Price and to make adjustments, subject to their mutual agreement, to the HL-2
Purchase Price due to inflation, change in product cost and/or other market
or competitive conditions. Edwards shall pay PLC within [**]days of the sale
the amount set forth in the column titled "Protection" specified in Schedule
7.3 for each such HL-2 Laser System that is sold to a customer listed on
Schedule 7.3 within three months of Effective Date of this Agreement.

                                      -11-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

         SECTION 7.4. PRODUCT ACCESSORIES. Edwards shall purchase from PLC
F.O.B PLC's manufacturing facility any Product accessory set forth on
Schedule 7.4 for the transfer price listed for such accessory on Schedule 7.4.

         SECTION 7.5. SHIPPING. At Edwards' request, PLC shall warehouse all
HL-2 Laser Systems purchased by Edwards at Edwards' segregated warehouse
within PLC's facility ("Edwards Facility"). Until the date [**] days after
the date of the termination of the transition services provided in Section
4.1, PLC shall deliver TMR Disposable Kits directly to the end user.
Thereafter, PLC shall deliver TMR Disposable Kits directly to Edwards. All
prices for the Products shall be F.O.B. PLC's manufacturing facility. The
prices will not include any federal, state or local sales, use, excise or
value added tax that may be applicable. If PLC has the legal obligation to
collect such taxes, the appropriate amount shall be added to Edwards' invoice
and paid by Edwards unless Edwards provides PLC with a valid tax exemption
certificate authorized by the appropriate taxing authority. PLC shall ship
the Products using the method of transportation specified by Edwards in the
purchase order. In all cases, title, risk of loss and all responsibility for
transportation, insurance and storage shall pass from PLC to Edwards upon
transfer of finished HL-2 Laser Systems from PLC to the Edwards Facility and
after such transfer PLC shall promptly issue an invoice related thereto to
Edwards.

         SECTION 7.6. PAYMENT. Full payment shall be made by Edwards to PLC
within [**] days from the invoice date which shall be shipping date for the
Products to Edwards.

                                 ARTICLE VIII

                      TERM AND TERMINATION; ANNUAL MEETING

         SECTION 8.1. TERM AND RENEWAL. This Agreement shall commence on the
date hereof (the "Effective Date") and be valid for an initial term of five
(5) years ("Initial Term"). Edwards shall have the option to extend the
Agreement on the same terms and conditions for an additional term of five (5)
years, PROVIDED that the TMR Disposable Kits sold by Edwards, measured for
the twelve-month period ending six months prior to the expiration of the
Initial Term, are used in at least [**]% of all intraoperative laser-based
transmyocardial revascularization procedures in the Territory for such period
as measured by a third-party study reasonably acceptable to PLC and Edwards
(the "Automatic Renewal Threshold"). If the parties cannot agree on any such
study, then they shall jointly commission a study by McKinsey & Company and
will be bound by such study. PLC and Edwards shall split the cost of the
McKinsey & Company study equally. If the

                                      -12-
<PAGE>

sale of Products by Edwards does not meet the Automatic Renewal Threshold, the
parties may agree to extend the Agreement on mutually acceptable terms and
conditions.

         SECTION 8.2. IMMEDIATE TERMINATION. This Agreement may be terminated
by either Edwards or PLC immediately in the event that (a) any breach by PLC
of Section 4.8; (b) any material breach by the other party remains uncured 60
days after written notice containing details of the breach has been delivered
to the other party; or (c) the other party shall file for protection from its
creditors under any applicable bankruptcy or insolvency laws, shall make an
assignment for the benefit of creditors, or shall have a receiver appointed
for its property. This Agreement may be terminated by Edwards upon one-year
notice, in the event Edwards decides in its sole reasonable discretion that
unfavorable market conditions exist for the Products in the Territory.

         SECTION 8.3. ANNUAL MEETING. The chief executive officer of PLC and
the executive in charge of the DBMR business for Edwards shall agree to meet
annually in order to discuss sales opportunities, current market trends and
to keep each other informed of pertinent events and competing products having
an impact upon the Products' marketability, including, but not limited to,
forecasts as to future demand.

                                  ARTICLE IX

                        WARRANTIES AND INDEMNIFICATION

         SECTION 9.1. WARRANTIES. PLC warrants that (a) it possesses good and
marketable title to all Products sold to Edwards under this Agreement; (b)
each Product conforms to its specifications and is fit for the purposes and
indications described in its labeling; (c) when available for sale in the
Territory the Products are or will be manufactured in conformity with all FDA
and ETL rules and regulations and applicable laws of the Territory; (d) the
Products have or will have obtained FDA approval to market and sell the
Products when the Products are available for sale in the Territory; (e) it is
the owner or licensor of the entire right, title and interest in the
intellectual property relating to the Products and, to the knowledge of PLC
and PLC Parent, the use by Edwards of any such intellectual property will not
violate any right of any third party; and (f) it complies and will continue
to comply with all applicable laws and regulations of the Territory with
respect to the Products.

         SECTION 9.2. INDEMNIFICATION BY PLC. PLC and PLC Parent shall
indemnify and hold harmless Edwards, its officers, directors, shareholders,
employees, parents, successors, affiliates, assigns, customers and users of
Products, in each case, from and against any and all costs or expenses
(including, without limitation, reasonable attorneys' fees, and the
reasonable out-of-pocket expenses of testifying and preparing for testimony
and responding to document and other information requests, whether or not a
party to such

                                      -13-
<PAGE>

litigation), judgments, fines, losses, claims (whether or not meritorious) and
damages (collectively, "Damages"), as incurred, to the extent they relate to,
arise out of or are the result of (i) the manufacture by PLC or use of any
Products; (ii) the design of any Products or component of the Products not
developed exclusively by Edwards; (iii) the failure of the Products to satisfy
any warranty made by PLC; (iv) by reason of the sale or use of the Products any
claim of infringement of patents, trademarks, trade names, or copyrights, any
claim of misappropriation or misuse of trade secrets or information or any
similar claim; (v) any claims with respect to any Scheduled Employee arising
from actions taken by PLC prior to the date hereof, and (vi) any claims with
respect to any Scheduled Employee arising from actions taken by PLC, unrelated
to this Agreement, prior to the exercise of the Sales and Marketing Option,
provided, however, that such indemnification shall in no event exceed $500,000.

         SECTION 9.3. INDEMNIFICATION BY EDWARDS. Edwards shall indemnify and
hold harmless PLC, its successors, affiliates and assigns, in each case, from
and against any and all Damages, as incurred, to the extent they relate to,
arise out of or are the result of Edwards' gross negligence or willful
misconduct in the promotion and sale of the Products by Edwards.

         SECTION 9.4. INDEMNIFICATION PROCEDURES. The party seeking
indemnification (the "Indemnified Party") pursuant to this Article IX shall
promptly notify the indemnifying party (the "Indemnifying Party"), in
writing, of such claim describing such claim in reasonable detail, PROVIDED
that the failure to provide such notice shall not affect the obligations of
the Indemnifying Party unless and only to the extent it is actually
prejudiced thereby. In the event that such claim involves a claim by a third
party against an Indemnified Party, the Indemnifying Party shall have 30 days
after receipt of such notice to decide whether it will undertake, conduct and
control, through counsel of its own choosing (but reasonably acceptable to
the Indemnified Party) and at its own expense, the settlement or defense
thereof unless (i) the Indemnifying Party is also a party to the proceeding
and the Indemnified Party determines in good faith that joint representation
would be inappropriate or (ii) the Indemnifying Party fails to provide
reasonable assurance to the Indemnified Party of its financial capacity to
defend such proceeding, and provide indemnification with respect thereto, and
if it so decides, the Indemnified Party shall cooperate with it in connection
therewith, PROVIDED that the Indemnified Party may participate in such
settlement or defense through counsel chosen by it, and PROVIDED FURTHER that
the fees and expenses of such counsel shall be borne by the Indemnified
Party. The Indemnifying Party shall not, without the written consent of the
Indemnified Party (which consent shall not be unreasonably withheld,
conditioned or delayed), settle or compromise any action, unless such
settlement or compromise includes an unconditional release of the Indemnified
Party. If the Indemnifying Party does not notify the Indemnified Party within
30 days after the receipt of notice of a claim

                                      -14-
<PAGE>

of indemnity hereunder that it elects to undertake the defense thereof, the
Indemnified Party shall have the right to contest, settle or compromise the
claim but shall not pay or settle any such claim without the consent of the
Indemnifying Party (which consent shall not be unreasonably withheld,
conditioned or delayed). The Indemnifying Party and the Indemnified Party shall
cooperate fully in all aspects of any investigation, defense, pre-trial
activities, trial, compromise, settlement or discharge of any claim in respect
of which indemnity is sought pursuant to Article IX, including, but not limited
to, providing the other party with reasonable access to employees and officers
(including as witnesses) and other information. The remedies provided in this
Article IX will not be exclusive of or limit any other remedies that may be
available to the Indemnified Parties.

                                  ARTICLE X

               INTELLECTUAL PROPERTY RIGHTS AND CONFIDENTIALITY

         SECTION 10.1. TRADEMARKS. Edwards shall have the right to indicate
to the public that it is an authorized distributor of the Products and to
market and sell the Products under the trademarks, service marks and trade
names that PLC may adopt from time to time. Edwards shall not alter, obscure
or remove any trademarks, service marks or trade names of PLC which are
contained on or in or affixed to the Products at the time of shipment.
Edwards shall not use any trademarks, service marks or trade names of PLC in
connection with any business conducted by Edwards other than dealing with the
Products in accordance with the terms of this Agreement. Edwards agrees that
its use of the trademarks, service marks and trade names of PLC shall not
create in its favor any right, title or interest therein and acknowledges
PLC's exclusive right, title and interest thereto. Edwards agrees that it
will not use, without PLC's prior written consent, any mark which is similar
to or is likely to be confused with any trademarks, service marks or trade
names of PLC. Edwards' rights to use the trademarks, service marks and trade
names of PLC as set forth in this Section 10.1 shall terminate upon
termination or expiration of this Agreement.

         SECTION 10.2. CONFIDENTIAL INFORMATION. In order to avoid disclosure
of confidential and proprietary information to any other person, firm or
corporation, the parties agree that during the term of this Agreement and for
a period of three years from the termination of this Agreement each will
treat any such information which is received from one another in writing and
clearly marked as "Confidential" or if disclosed orally, which is confirmed
in writing as "Confidential" within thirty (30) days of initial disclosure,
with the same degree of care that each employs with respect to its own
information which it does not desire to have published or disseminated. It is
understood that each party shall be liable for any unauthorized disclosure
should it fail to safeguard the disclosed information with

                                      -15-
<PAGE>

such care. This obligation shall survive the termination or expiration of this
Agreement. The parties shall not have any obligation with respect to such
information which is:

         (a) independently developed by the receiving party without the
benefit of the disclosure or is already known to the receiving party at the
time of the disclosure, as evidenced by written documentation;

         (b) publicly known or becomes publicly known without the wrongful
act or breach of this Agreement by the receiving party; or

         (c) rightfully received by the receiving party from a third-party
who is not under any obligation of confidentiality or trade secret obligation
to the originating party.

                                   ARTICLE XI

                                  MISCELLANEOUS

         SECTION 11.1. RELATIONSHIP. The relationship of Edwards and PLC
established by this Agreement is of independent contractors and not agents
(except as set forth in Section 2.1), and nothing in this Agreement shall be
construed:

         (a) To give either party the power to direct or control the daily
activities of the other party beyond the obligations imposed on Edwards and
PLC, respectively, by this Agreement;

         (b) To constitute the parties as partners, joint ventures, co-owners
or otherwise as participants in joint undertaking; or

         (c) To allow either party to create or assume any obligation on
behalf of the other party for any purpose whatsoever. The purchase,
promotion, and resale of, or any other legal transactions concerning the
Products hereunder shall be carried out in the name of and for the account of
Edwards as principal, and Edwards shall not enter into any agreement with
third persons binding in any way on PLC.

          SECTION 11.2. NO CONFLICT. Each party represents and warrants to
the other parties that it is not subject to any contractual obligation or
restraint which will materially interfere with its right and ability to
perform pursuant to the terms of this Agreement.

          SECTION 11.3. GOVERNING LAW. This Agreement shall be governed by,
interpreted under, and construed in accordance with the internal laws of the
State of New York, including,

                                      -16-
<PAGE>

without limitation, Sections 5-1401, 5-1402 of the New York General Obligations
Law and New York Civil Practice Laws and Rules 327(b).

          SECTION 11.4. ESCALATION. Edwards and PLC (and/or PLC Parent) will
attempt in good faith to resolve expeditiously any dispute, claim or
controversy arising out of or relating to this Agreement (the "Dispute")
promptly by negotiations between executives who have authority to settle the
controversy and who are at a higher level of management than the persons with
direct responsibility for the administration of this Agreement. Either party
may give the other party written notice (the "Escalation Notice") of any
Dispute not resolved in the normal course of business. Within 15 days after
delivery of the Escalation Notice, the receiving party shall submit to the
other a written response. The Escalation Notice and the response thereto
shall include (a) a statement of each party's position and a summary of
arguments supporting that position, and (b) the name and title of the
executive who will represent that party and of any other person who will
accompany the executive. Within 30 days after delivery of the Escalation
Notice, the executives of both parties shall meet at a mutually acceptable
time and place, and thereafter as often as they reasonably deem necessary, to
attempt to resolve the Dispute. All reasonable requests for information made
by one party to the other will be honored. All negotiations pursuant to this
clause are confidential and shall be treated as compromise and settlement
negotiations for purposes of applicable rules of evidence. The parties shall
attempt to resolve any Dispute pursuant to the procedure set forth in this
Section 11.4 for a period up to 60 days from the date of delivery of the
Escalation Notice before resorting to other available remedies; PROVIDED,
HOWEVER, nothing contained in this Section 11.4 shall prevent any party from
resorting to judicial process if injunctive or other equitable relief from a
court is necessary to prevent serious and irreparable injury to it or to
others. The use of the procedure set forth in this Section 11.4 will not be
construed under the doctrine of laches, waiver or estoppel to affect
adversely any party's right to assert any claim or defense.

          SECTION 11.5. JURISDICTION AND CONSENT TO SERVICE. In accordance
with the laws of the State of New York, and without limiting the jurisdiction
or venue of any other court, the parties (a) agree that any suit, action or
proceeding arising out of or relating to this Agreement shall be brought
solely in the state or federal courts of New York; (b) consent to the
exclusive jurisdiction of each such court in any suit, action or proceeding
relating to or arising out of this Agreement; (c) waive any objection which
any of them may have to the laying of venue in any such suit, action or
proceeding in any such court; and (d) agree that service of any court paper
in any such suit, action or proceeding may be made in any manner as may be
provided under the applicable laws or court rules governing service of
process in such court.

                                      -17-
<PAGE>

          SECTION 11.6. NOTICES. All notices, demands, requests, consents,
approvals or other communications required or permitted to be given hereunder
or which are given with respect to this Agreement shall be in writing and
shall be delivered (charges prepaid, receipt confirmed or return receipt
requested (if available)) by hand, by nationally recognized air courier
service, by certified mail or facsimile, addressed as set forth below or to
such other address as such party shall have specified most recently by
written notice. Notice shall be deemed given and effective (i) if delivered
by hand or by nationally recognized courier service, when delivered at the
address specified in this Section 11.6 (or in accordance with the latest
unrevoked written direction from such party), (ii) if by certified mail, upon
mailing or (iii) if given by facsimile when such facsimile is transmitted to
the fax number specified in this Section 11.6 (or in accordance with the
latest unrevoked written direction from such party), provided the appropriate
confirmation is received.

                    To PLC:

                            PLC Systems Inc.
                            10 Forge Park
                            Franklin, MA 02038
                            Attention:  Chief Executive Officer
                            Fax: (508) 541-7990

                    with a copy (which shall not constitute notice) to:

                            Hale and Dorr LLP
                            60 State Street
                            Boston, MA  02109
                            Attention:  Steven D. Singer, Esq.
                            Fax: (617) 526-5000

                    To Edwards:

                            Edwards Lifesciences LLC
                            One Edwards Way
                            Irvine, California 92614
                            Attention:  Associate General Counsel
                            Fax: (949) 250-6850

                                      -18-
<PAGE>

                     with a copy (which shall not constitute notice) to:

                            Skadden, Arps, Slate, Meagher & Flom LLP
                            300 South Grand Avenue, Suite 3400
                            Los Angeles, California  90071-3144
                            Attention:  Joseph J. Giunta, Esq.
                            Fax: (213) 687-5600

          SECTION 11.7. INTERPRETATION. When a reference is made in this
Agreement to a Section, Schedule or Exhibit, such reference shall be to a
Section, Schedule or Exhibit of this Agreement unless otherwise indicated.
When a reference is made in this Agreement to a specific Schedule, such
reference shall be deemed to include, to the extent applicable, all the other
Schedules. The table of contents, table of definitions, titles and headings
contained in this Agreement are for reference purposes only and shall not
affect in any way the meaning or interpretation of this Agreement. When the
words "includes" or "including" are used in this Agreement, they shall be
deemed to be followed by the words "without limitation." All accounting terms
not defined in this Agreement shall have the meanings determined by generally
accepted accounting principles as of the date hereof. All capitalized terms
defined herein are equally applicable to both the singular and plural forms
of such terms.

          SECTION 11.8. SEVERABILITY. In the event that any one or more of
the provisions contained herein, or the application thereof in any
circumstances, is held invalid, illegal or unenforceable in any respect for
any reason, the parties shall negotiate in good faith with a view to the
substitution therefore of a suitable and equitable solution in order to carry
out, so far as may be valid and enforceable, the intent and purpose of such
invalid provision; PROVIDED, HOWEVER, that the validity, legality and
enforceability of any such provision in every other respect and of the
remaining provisions contained herein shall not be in any way impaired
thereby, it being intended that all of the rights and privileges of the
parties hereto shall be enforceable to the fullest extent permitted by law.

          SECTION 11.9. COUNTERPARTS. This Agreement may be executed in two
or more counterparts, each of which shall be deemed an original and all of
which shall, taken together, be considered one and the same agreement, it
being understood that the parties need not sign the same counterpart.

          SECTION 11.10. ENTIRE AGREEMENT; NO THIRD PARTY BENEFICIARIES. This
Agreement and the other Transaction Agreements (as such term is defined in
the Securities Purchase Agreement, dated as of January 7, 2001, by and among
Edwards Lifesciences Corporation, PLC and PLC Parent), including all exhibits
hereto and thereto, by and among the parties hereto,

                                      -19-
<PAGE>

         constitute the entire agreement of the parties with respect to the
subject matter hereof and supersede all prior and contemporaneous agreements,
representations, understandings, negotiations and discussions between the
parties, whether oral or written, with respect to the subject matter hereof; and

         shall be binding upon and shall inure to the benefit of each of the
parties hereto and thereto and their respective successors and permitted assigns
and is not intended to confer any rights, remedies or benefits on any Persons
other than as expressly set forth in this Section 11.10.

          SECTION 11.11. AMENDMENTS AND MODIFICATIONS; WAIVERS AND EXTENSIONS.

         No amendment, modification or termination of this Agreement shall be
binding upon any other party unless executed in writing by the parties hereto
intending to be bound thereby.

         Any party to this Agreement may waive any right, breach or default
which such party has the right to waive; provided that such waiver will not be
effective against the waiving party unless it is in writing, is signed by such
party, and specifically refers to this Agreement. Waivers may be made in advance
or after the right waived has arisen or the breach or default waived has
occurred. Any waiver may be conditional. No waiver of any breach of any
agreement or provision herein contained shall be deemed a waiver of any
preceding or succeeding breach thereof nor of any other agreement or provision
herein contained. No failure or delay in exercising any right, power or
privilege hereunder shall be deemed a waiver or extension of the time for
performance of any other obligations or acts nor shall any single or partial
exercise thereof preclude any other or further exercise thereof or the exercise
of any other right, power or privilege.

          SECTION 11.12. ASSIGNMENT. Neither this Agreement nor any of the
rights, duties or obligations hereunder may be assigned or delegated by any
of the parties hereto without the prior written consent of PLC or Edwards, as
the case may be, which may be withheld in its sole discretion except that
Edwards may assign all its rights and obligations to any subsidiary of
Edwards Lifesciences Corporation. Any attempted assignment or delegation of
rights, duties or obligations hereunder in contravention hereof shall be void
and of no effect.

          SECTION 11.13. EXHIBITS. Each of the exhibits referred to herein
and attached hereto is an integral part of this Agreement and is incorporated
herein by reference.

          SECTION 11.14. EXPENSES. Except as otherwise provided in this
Agreement, each party to this Agreement shall bear its respective expenses
incurred in connection with the preparation, execution, and performance of
this Agreement and the transactions

                                      -20-
<PAGE>

contemplated hereby, including all fees and expenses of agents, representations,
counsel and accountants.

          SECTION 11.15. NO CONSEQUENTIAL OR PUNITIVE DAMAGES. If any party
claims any breach of this Agreement by the other party or otherwise becomes
dissatisfied with any matter relating hereto or arising herefrom, it shall
have no right to seek consequential or punitive damages and each party hereby
waives any right it may have to seek such punitive or consequential damages.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first above written.

                 PLC SYSTEMS INC.

                 By:   /s/ JAMES G. THOMASCH
                       --------------------------------------------------------
                       Name: James G. Thomasch
                       Title: Senior Vice President and Chief Financial Officer

                 PLC MEDICAL SYSTEMS, INC.

                 By:   /s/ JAMES G. THOMASCH
                       --------------------------------------------------------
                       Name: James G. Thomasch
                       Title: Senior Vice President and Chief Financial Officer

                 EDWARDS LIFESCIENCES LLC

                 By:   /s/ JOHN H. KEHL, JR.
                       --------------------------------------------------------
                       Name:  John H. Kehl, Jr.
                       Title: Corporate Vice President

                                      -21-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                    EXHIBIT A

                             DESCRIPTION OF PRODUCTS

1.       HL-2 LASER SYSTEM INCLUDING:

                  [**]

2.       TMR DISPOSABLE KIT INCLUDING:

                  [**]

Products shall also include [**] and or [**] the products, [**] and [**]
products [**] in the field [**].

Products do not include the HL-1 Laser System.

                                      -22-
<PAGE>

                                  SCHEDULE 2.1

                                  DISTRIBUTORS

1.  Criticor (West Coast)

2.  Central Medical (Wisconsin, Minnesota)

                                      -23-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                  SCHEDULE 3.3

                                 SALES PERSONNEL

CAPITAL SALES REPRESENTATIVES
-----------------------------

[**]

MANAGER OF CLINICAL TRAINING
----------------------------

[**]CLINICAL SPECIALISTS
    --------------------
[**]

(i)      $[**]

(ii)     A ranking of no less than "satisfactory" (or PLC's equivalent) on the
         most recent performance review immediately prior to Edwards' exercise
         of the Sales and Marketing Option.

                                      -24-
<PAGE>

                                  SCHEDULE 4.1

                               TRANSITION SERVICES

1.       Customer service: Provide seamless support to customers during
         transition to include order placement, returns, problem resolution,
         questions, etc. In addition, provide support and data to Edwards
         Customer Service relative to customers, products and the sales force.

2.       Invoicing: Provide accounts receivable support to customers during
         transition to include invoicing, collections, problem resolution,
         questions, etc. In addition, provide support and data to Edwards
         Accounts Receivable relative to customers, aging and other information.

                                      -25-
<PAGE>

                                  SCHEDULE 4.5

   INSTALLATION SERVICES AND SERVICES RELATING TO EXTENDED SERVICE AGREEMENTS

Installation Support Service includes:

         (i)      installation of HL-2 Laser System at hospital

         (ii)     laser operator in-service training at hospital

Extended Service Agreements can include:

                  all or part of the services defined in Schedule 4.6. The exact
services are detailed in extended service contract agreements with the customer
and are tailored to the customer requirements.

PLC is not responsible for the re-installation or transportation of the Product
among multiple facilities.

                                      -26-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                  SCHEDULE 4.6

                  WARRANTY AND PREVENTIVE MAINTENANCE SERVICES

Preventive Maintenance are planned services which include:
         (i)      Cleaning of optics
         (ii)     In-service for any new operating room personnel
         (iii)    Calibration of energy readings
         (iv)     Safety checks
         (v)      Replacement of air purge filter
         (vi)     any adjustments to make the product meet performance
                  specifications

Warranty Service is unplanned services which include:
         (i)      any necessary travel, labor and material expense to repair or
                  replace a defective product or product component that is not
                  meeting published PLC performance specifications.

"costs" shall include all material costs at PLC's fully absorbed standard
manufacturing cost and labor and travel-related costs for PLC personnel
calculated at the rate of $[**] per day, billed in whole day increments.

                                      -27-
<PAGE>

                                  SCHEDULE 4.8

                           PRODUCT LIABILITY INSURANCE

                                 To be provided.

                                      -28-
<PAGE>

                                  SCHEDULE 5.1

                                 MARKETING PLAN

                                 To be provided.

                                      -29-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                  SCHEDULE 5.2

                                   SALES PLAN

PLC and Edwards have developed a joint sales strategy to drive utilization
during the [**] agreement. Edwards and PLC anticipate [**] based on the [**].
Specific objectives, actions and activities to accomplish the goals are
highlighted below and the details are supported by the jointly developed master
Sales Plan.

Objective:        [**].

Expectation:      Edwards sales organization will develop skill sets that allow
                  them to successfully manage the process of increasing kit
                  sales by gaining necessary knowledge & devoting time needed to
                  drive procedural increases in assigned territory.

Action:           [**] will be established for the [**] in [**].

Activities:       The following activities have been scheduled [**];

<TABLE>
<CAPTION>

            ACTIVITY                LOCATION           DATE              ATTENDEES
            --------                --------           ----              ---------
<S>                               <C>              <C>                <C>

A. Implementation/Launch            Chicago            [**]               PLC/EW

B. Training-Patient Selection       STS                [**]               EW/PLC

C. Edwards National Meeting         Irvine, CA         [**]               EW/PLC mgmt

D. Combine Training Event           not determined     [**]               EW/PLC

E. Combine Training Event           not determined     [**]               EW/PLC

F. PLC representatives [**] assist in the attainment of sales objectives.
</TABLE>

*Measurements will be established to monitor progress in key areas.

                                      -30-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                  SCHEDULE 7.3

                           HL-2 LASER SYSTEM CUSTOMERS

<TABLE>
<CAPTION>

EST. COMMISSION
ACCOUNT                    CITY              REP              DEAL              CLOSE          PROTECTION
<S>                       <C>             <C>               <C>               <C>            <C>

[**]                       [**]             [**]              [**]              [**]             $[**]

[**]                       [**]             [**]              [**]              [**]             $[**]

[**]                       [**]             [**]              [**]              [**]             $[**]

[**]                       [**]             [**]              [**]              [**]             $[**]

[**]                       [**]             [**]              [**]              [**]             $[**]

[**]                       [**]             [**]              [**]              [**]             $[**]
</TABLE>

                                      -31-
<PAGE>

     Confidential Materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                  SCHEDULE 7.4

                               PRODUCT ACCESSORIES

<TABLE>
<CAPTION>

                                                                          PLC      EDWARDS   SHIPPING     SHIPPING
  PART                            MODEL                      SHELF       SALE     TRANSFER    WEIGHT     DIMENSIONS
 NUMBER      DESCRIPTION         USED ON         QTY   UNIT  LIFE        PRICE      PRICE      (LBS)      (INCHES)      NOTES:
-------    -----------------     ---------      ----   ----  -----       -----    ---------  --------    ----------   --------
<S>        <C>                <C>             <C>     <C>   <C>        <C>      <C>         <C>        <C>            <C>

EP00100    Footswitch             both           1ea          n/a        $[**]      $[**]       8           12x6.5x5.5
FL00002    Safety Goggles         both           1ea          n/a        $[**]      $[**]       1          7.5x6.5x5.5
                                                                                                                       Fedex
           Remote Enable                                                                                               small
SB00056    Cable                  both           1ea          n/a        $[**]      $[**]       1             11x13x1.5box
                                                                                                                       Fedex
                                                                                                                       small
SB00076    Lens Cell              both           1ea          n/a        $[**]      $[**]       1             11x13x1.5box
                                                                                                                       Fedex
                                                                                                                       small
CA00097    ECG Trunk Cable        HL-2           1ea          n/a        $[**]      $[**]       1             11x13x1.5box
                                                                                                                       Fedex
                                                                                                                       small
CA00098    ECG 5 Lead Set         HL-2           1ea          n/a        $[**]      $[**]       1             11x13x1.5box
                                                                                                                       Fedex
           Filter, Hepa, 0.3                                                                                           small
FL00004    micron                 HL-2           1ea          n/a        $[**]      $[**]       1             11x13x1.5box
                                                                                                                       Fedex
           HL-2 Operators                                                                                              medium
LA00181    Manual                 HL-2           1ea          n/a        $[**]      $[**]7      3         13.5x11.5x2.5box
                                                                                                                       Fedex
                                                                                                                       small
LA00202    Warning Sign HL-2      HL-2           1ea          n/a        $[**]      $[**]       1             11x13x1.5box
</TABLE>

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