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EXHIBIT 10.22    
    

        EQUIPMENT LOAN AND SECURITY AGREEMENT 

Dated
as of December 27, 2001 

by
and between 

GATX
VENTURES, INC.

as Lender 

and

NUVASIVE, INC.

a Delaware corporation

10065 Old Grove Road

San Diego, California 92131

as Borrower 

CREDIT
AMOUNT: $1,000,000 

	

 	
 	

 
	Repayment Period:	 	36 months
	

Treasury Note Maturity:	
 	

36 months
	

Loan Margin:	
 	

800 basis points
	

Commitment Termination Date:	
 	

July 31, 2002

        The
terms and information set forth on this cover page are a part of the attached Equipment Loan and Security Agreement, dated as of the date first written above (this
"Agreement"), entered into by and between GATX Ventures, Inc. ("Lender") and
NuVasive, Inc. ("Borrower"). The terms and conditions of this Agreement agreed to between the parties hereto are as follows: 

  

 
 

AGREEMENT    
    

        1.    Definitions and Construction.    

        1.1    Definitions.    As used in this Agreement, the following terms shall have the following definitions: 

        "Affiliate" means any Person that owns or controls directly or indirectly ten percent or more of the stock of another entity, any Person
that controls or is controlled by or is under common control with such Persons or any Affiliate of such Persons or each of such Person's officers, directors, joint venturers or partners. 

        "Agreement" means this Equipment Loan and Security Agreement, as the same may from time to time be amended or supplemented. 

        "Basic Rate" means, as of the relevant Funding Date, the per annum rate of interest (based on a year of twelve 30-day months)
equal to the sum of (a) the U.S. Treasury note yield to maturity for a term equal to the Treasury Note Maturity as quoted in the Western Edition of The Wall Street Journal on the date the Loan
Agreement Supplement is prepared, plus (b) the Loan Margin. Notwithstanding the foregoing, the Basic Rate shall not exceed the highest rate permitted by applicable law to be charged on
commercial loans. 

        "Borrower" has the meaning set forth on the cover page hereof. 

        "Borrower's Home State" means California. 

        "Business Day" means any day that is not a Saturday, Sunday, or other day on which banking institutions are authorized or required to
close in Borrower's Home State. 

        "Closing Date" means the date that each of the conditions precedent listed in  Section 3.1 has been satisfied or waived in writing by Lender. 

        "Code" means the Uniform Commercial Code as adopted and in effect in the State of California, as amended from time to time, provided that
if by reason of mandatory provisions of law, the creation and/or perfection or the effect of perfection or non-perfection of the security interest in any Collateral is governed by the
Uniform Commercial Code as in effect in a jurisdiction other than California, the term "Code" shall also mean the Uniform Commercial Code as in effect from time to time in such jurisdiction for
purposes of the provisions hereof relating to such creation, perfection or effect of perfection or non-perfection. 

        "Collateral" has the meaning given that term in Section 4.1, including, without
limitation, all Financed Equipment listed in any Loan Agreement Supplement executed from time to time pursuant to Section 4.2. 

        "Commitment Termination Date" means the date following such term on the cover page of this Agreement. 

        "Credit Amount" means the amount set forth following such term on the cover page of this Agreement. 

        "Default" means any event which with the passing of time or the giving of notice or both would become an Event of Default hereunder. 

        "Default Rate" means the per annum rate of interest equal to 5% over the Basic Rate, but such rate shall in no event be more than the
highest rate permitted by applicable law to be charged on commercial loans. 

        "Disclosure Schedule" means Exhibit A attached hereto. 

1

 

        "Eligible Equipment" means, to the extent reasonably acceptable to Lender, Equipment (excluding any and all freight, installation, taxes
and other soft costs relating to such Equipment) consisting of computer equipment, data servers, communications equipment, office equipment and furnishings. 

        "Environmental Laws" means all foreign, federal, state or local laws, statutes, common law duties, rules, regulations, ordinances and
codes, together with all administrative orders, directed duties, requests, licenses, authorizations and permits of, and agreements with, any Governmental Authorities, in each case relating to
environmental, health, safety and land use matters, including the Comprehensive Environmental Response, Compensation and Liability Act of 1980, the Clean Air Act, the Federal Water Pollution Control
Act of 1972, the Solid Waste Disposal Act, the Federal Resource Conservation and Recovery Act, the Toxic Substances Control Act and the Emergency Planning and Community
Right-to-Know Act. 

        "Equipment" has the meaning given to such term in Section 4.1. 

        "Equity Securities" of any Person shall mean (a) all common stock, preferred stock, participations, shares, partnership interests
or other equity interests in and of such Person (regardless of how designated and whether or not voting or non-voting) and (b) all warrants, options and other rights to acquire any
of the foregoing. 

        "Event of Default" has the meaning given to such term in Section 8. 

        "Event of Loss" has the meaning given to such term in Section 6.10. 

        "Financed Equipment" has the meaning given to such term in Annex A to any Loan Agreement Supplement, as amended or supplemented from time
to time. 

        "Funding Date" means any date on which a Loan is made to or on account of Borrower under this Agreement. 

        "GAAP" means generally accepted accounting principles as in effect in the United States of America from time to time, consistently
applied. 

        "Governmental Authority" means (a) any federal, state, county, municipal or foreign government, or political subdivision thereof,
(b) any governmental or quasi-governmental agency, authority, board,
bureau, commission, department, instrumentality or public body, (c) any court or administrative tribunal or (d) with respect to any Person, any arbitration tribunal or other
non-governmental authority to whose jurisdiction that Person has consented. 

        "Hazardous Materials" means all those substances which are regulated by, or which may form the basis of liability under, any Environmental
Law, including all substances identified under any Environmental Law as a pollutant, contaminant, hazardous waste, hazardous constituent, special waste, hazardous substance, hazardous material, or
toxic substance, or petroleum or petroleum derived substance or waste. 

        "Indebtedness" means, with respect to Borrower or any Subsidiary, the aggregate amount of, without duplication, (a) all obligations
of such Person for borrowed money, (b) all obligations of such Person evidenced by bonds, debentures, notes or other similar instruments, (c) all obligations of such Person to pay the
deferred purchase price of property or services (excluding trade payables aged less than 180 days), (d) all capital lease obligations of such Person, (e) all obligations or
liabilities of others secured by a Lien on any asset of such Person, whether or not such obligation or liability is assumed, (f) all obligations or liabilities of others guaranteed by such
Person; and (g) any other obligations or liabilities which are required by GAAP to be shown as debt on the balance sheet of such Person. Unless otherwise 

2

 

indicated,
the term "Indebtedness" shall include all Indebtedness of Borrower and the Subsidiaries. 

        "Interim Payment" means, with respect to each Loan, an amount equal to the initial Loan Amount multiplied by the percentage equal to the
product of (i) the quotient derived from dividing the initial Loan Factor with respect to such Loan by 30, and (ii) the number of days from (and including) the Funding Date of such Loan
to (but not including) the first Payment Date with respect to such Loan. 

        "Investment" shall mean the purchase or acquisition of any capital stock, equity interest, or any obligations or other securities of, or
any interest in, any Person, or the extension of any advance, loan, extension of credit or capital contribution to, or any other investment in, any Person. 

        "Landlord Agreement" means an agreement substantially in the form of Exhibit E or
such other form as Lender may agree to accept. 

        "Lender" has the meaning set forth on the cover page hereof. 

        "Lender's Expenses" means all reasonable costs or expenses (including reasonable attorneys' fees and expenses) incurred in connection with
the preparation, negotiation, documentation, administration and funding of the Loan Documents; and Lender's reasonable attorneys' fees, costs and expenses incurred in amending, modifying, enforcing or
defending the Loan Documents (including fees and expenses of appeal or review), including the exercise of any rights or remedies afforded hereunder or under applicable law, whether or not suit is
brought, whether before or after bankruptcy or insolvency, including without limitation all fees and costs incurred by Lender in connection with Lender's enforcement of its rights in a bankruptcy or
insolvency proceeding filed by or against Borrower or its Property. 

        "Lien" means any voluntary or involuntary security interest, pledge, bailment, lease, mortgage, hypothecation, conditional sales and title
retention agreement, encumbrance or other lien with respect to any Property in favor of any Person. 

        "Loan" means each advance of credit by Lender to Borrower under this Agreement. 

        "Loan Agreement Supplement" means a supplement to this Agreement in substantially the form of  Exhibit C. 

        "Loan Amount" means, with respect to each Loan, as of any date, the original principal amount of such Loan less prepayments of such Loan
paid pursuant to Section 6.10. 

        "Loan Documents" means, collectively, this Agreement, each Loan Agreement Supplement, the Warrant, any Landlord Agreement, any Service
Provider's Consent and all other documents, instruments and agreements entered into in connection with this Agreement, all as amended or extended from time to time. 

        "Loan Factor" means, with respect to each Loan, the amount set forth as a percentage in the Loan Terms Schedule with respect to such Loan,
which fully amortizes the Loan over the Repayment Period applicable to such Loan in equal periodic installments at the Basic Rate. 

        "Loan Margin" means the number of basis points set forth following such terms on the cover page of this Agreement. 

        "Loan Terms Schedule" means, with respect to each Loan, Annex B to the Loan Agreement Supplement prepared by Lender in connection with
such Loan. 

        "Loan Value" means with respect to each Loan, an amount equal to the sum of all remaining unpaid Scheduled Payments discounted to the
relevant date at a rate of six percent 

3

 

(6%)
per annum, but shall not exceed the Loan Amount for such Loan; the "relevant date" shall be the Payment Date on which payment of such amount is to be made, or if such date is not a Payment Date,
on the Payment Date immediately succeeding such date. 

        "Maturity Date" means, with respect to each Loan, the last day of the Repayment Period for such Loan, or if earlier, the date of
acceleration of such Loan following an Event of Default or the date of prepayment, whichever is applicable. 

        "Minimum Funding Amount" means $50,000. 

        "Obligations" means all debt, principal, interest, fees, charges, expenses and attorneys' fees and costs and other amounts, obligations,
covenants, and duties owing by Borrower to Lender of any kind and description pursuant to or evidenced by the Loan Documents, whether direct or indirect, absolute or contingent, due or to become due,
now existing or hereafter arising, including the Loan Value due with respect to the Loans, and further including all Lender's Expenses. 

        "Officer's Certificate" shall mean a certificate executed by a Responsible Officer of Borrower substantially in the form of  Exhibit G or such other form as Lender
may agree to accept. 

        "Other Equipment" means, to the extent reasonably acceptable to Lender, tenant improvements and buildout costs, software, software
licenses, tooling, equipment specially manufactured for Borrower, and freight, installation and sales taxes relating to Eligible Equipment and other soft costs. 

        "Payment Date" has the meaning given to that term in Section 2.2(a). 

        "Permitted Indebtedness" means and includes: 

        (a)   Indebtedness
of Borrower to Lender; 

        (b)   Indebtedness
of Borrower secured by Liens upon any equipment or other personal property acquired by Borrower after the date hereof to secure (i) the purchase
price of such equipment or other personal property or (ii) lease obligations or indebtedness incurred solely for the purpose of financing the acquisition of such equipment or other personal
property; provided that (A) such equipment or personal property is not Financed Equipment, (B) such Liens are confined solely to the
equipment or other personal property so acquired and the amount secured does not exceed the acquisition price thereof, and (C) no such Lien shall be created, incurred, assumed or suffered to
exist in favor of Borrower's officers, directors or shareholders holding five percent (5%) or more of Borrower's Equity Securities; 

        (c)   Indebtedness
arising from the endorsement of instruments in the ordinary course of business; 

        (d)   Indebtedness
existing on the date hereof and set forth on the Disclosure Schedule; 

        (e)   Indebtedness
consisting of a revolving credit facility in which the loans are limited to less than 100% of Borrower's outstanding accounts receivable and which are
secured solely by Borrower's accounts receivable (and general intangibles in the nature of rights to payment) and the proceeds thereof, 

        (f)    Subordinated
Indebtedness; and 

        (g)   Extensions,
refinancings, modifications, amendments and restatements of any of items (a) through (f) above; provided that the principal amount thereof is
not increased 

4

 

or
the terms thereof are not modified to impose more burdensome terms upon Borrower; and provided, further, that any extension, renewal or replacement of any Lien in connection with this Section shall
be limited to the property encumbered by the existing lien. 

        "Permitted Liens" means (a) the Lien created by this Agreement, and (b) Liens for fees, taxes, levies, imposts, duties or
other governmental charges of any kind which are not yet delinquent or which are being contested in good faith by appropriate proceedings which suspend the collection thereof
(provided, however, that such proceedings do not involve any substantial danger of the sale, forfeiture
or loss of any item of Financed Equipment and that Borrower has adequately bonded such Lien or reserves sufficient to discharge such Lien have been provided on the books of Borrower). 

        "Person" means and includes any individual, any partnership, any corporation, any business trust, any joint stock company, any limited
liability company, any unincorporated association or any other entity and any domestic or foreign national, state or local government, any political subdivision thereof, and any department, agency,
authority or bureau of any of the foregoing. 

        "Property" means any interest in any kind of property or asset, whether real, personal or mixed, whether tangible or intangible. 

        "Repayment Period" means the period beginning on the first Payment Date and continuing for the Repayment Period set forth following such
term on the cover page of this Agreement. 

        "Scheduled Payments" has the meaning given to such term in Section 2.2(a). 

        "Service Provider's Consent" means an agreement substantially in the form of  Exhibit F or such other form as Lender may agree to accept. 

        "Stated Cost" means (i) with respect to each item of Eligible Equipment, the original cost to Borrower of the item of Eligible
Equipment, and (ii) with respect to each item of Other Equipment, the original cost to Borrower of the item of Other Equipment; provided, however, if an item of Eligible Equipment or Other
Equipment was delivered to Borrower by the manufacturer or vendor more than 90 days (or, for purposes of the first Loan only, more than 120 days) prior to the Funding Date of the Loan
relating to such Equipment, as evidenced by the invoice date of such Equipment, and Lender agrees to fund such item, the Stated Cost of such item shall be equal to Lender's appraised value. 

        "Subordinated Indebtedness" means Indebtedness subordinated to the Obligations on terms and conditions acceptable to Lender in its sole
discretion. 

        "Subsidiary" means any corporation of which a majority of the outstanding capital stock entitled to vote for the election of directors
(otherwise than as the result of a default) is owned by Borrower directly or indirectly through Subsidiaries. 

        "Term" means the period from and after the date hereof until the payment in full of all amounts and liabilities payable under this
Agreement and the other Loan Documents, including principal and interest on the Loans (including all Scheduled Payments with respect to each Loan). 

        "Treasury Note Maturity" means the periods of months set forth following such term on the cover page of this Agreement. 

        "Warrant" means the separate warrant in favor of the Lender or its designee to purchase securities of Borrower substantially in the form
of Exhibit B. 

5

 

        1.2    Other Interpretive Provisions.    References in this Agreement to "Articles," "Sections," "Exhibits,
"Schedules" and "Annexes" are to recitals, articles, sections, exhibits, schedules and annexes herein and hereto unless otherwise indicated. References in this Agreement and each of the other Loan
Documents to any document, instrument or agreement shall include (a) all exhibits, schedules, annexes and other attachments thereto, (b) all documents, instruments or agreements issued
or executed in replacement thereof, and (c) such document, instrument or agreement, or replacement or predecessor thereto, as amended, modified and supplemented from time to time and in effect
at any given time. The words "hereof," "herein" and "hereunder" and words of similar import when used in this Agreement or any other Loan Document shall refer to this Agreement or such other Loan
Document, as the case may be, as a whole and not to any particular provision of this Agreement or such other Loan Document, as the case may be. The words "include" and "including" and words or similar
import when used in this Agreement or any other Loan Document shall not be construed to be limiting or exclusive. Unless otherwise indicated in this Agreement or any other Loan Document, all
accounting terms used in this Agreement or any other Loan Document shall be construed, and all accounting and financial computations hereunder or thereunder shall be computed, in accordance with GAAP,
and all terms describing Collateral shall be construed in accordance with the Code. 

        2.    Loans; Repayment.    

        2.1    Commitment.    

        (a)    The Credit Amount.    Subject to the terms and conditions of this Agreement and relying upon the
representations and warranties herein set forth as and when made or deemed to be made, Lender agrees to lend to Borrower from time to time on or prior to the Commitment Termination Date, the Loans in
an amount equal to (i) one hundred percent (100%) of the Stated Cost of Eligible Equipment, and (ii) one hundred percent (100%) of the Stated Cost of Other Equipment; provided that the
aggregate principal amount of the Loans shall not exceed the Credit Amount at such time; provided further that the aggregate original principal amount of all Loans relating to the financing of Other
Equipment shall not at any time exceed twenty percent (20%) of the aggregate original principal amount of all Loans. Notwithstanding the foregoing, Five Hundred Thousand Dollars ($500,000) of the
Credit Amount is available, subject to the terms hereunder, only for Loans with a Funding Date on or before December 31, 2001, and if this portion of the Credit Amount remains unused by
December 31, 2001, it will no longer be available; the remaining Five Hundred Thousand Dollars ($500,000) of the
Credit Amount shall be available for Loans with a Funding Date on or before July 31, 2002. Loans may not be prepaid except in accordance with  Section 2.3. 

        (b)    Promissory Note.    Each Loan Terms Schedule shall be considered a promissory note evidencing the amounts due
hereunder for all purposes. 

        (c)    Use of Proceeds.    The proceeds of the Loans shall be used solely for the purchase of Eligible Equipment or
Other Equipment or reimbursement to Borrower of the Stated Cost of Eligible Equipment or Other Equipment. 

        (d)    Termination of Commitment to Lend.    Notwithstanding anything in the Loan Documents, Lender's obligation to
lend the undisbursed portion of the Credit Amount to Borrower hereunder shall terminate on the earlier of (1) at Lender's sole election, the occurrence of any Default or Event of Default
hereunder, and (ii), except as provided in Section 2.1 (a) above, the Commitment Termination Date. Notwithstanding the foregoing, Lender's obligation to lend the undisbursed portion of
the Credit Amount to Borrower shall terminate if, in Lender's sole judgment, there has been a material adverse change in the general affairs, management, results of operations, condition (financial or
otherwise) or prospects of Borrower, whether or not arising from transactions in the ordinary course of 

6

 

business,
or there has been any material adverse deviation by Borrower from the business plan of Borrower presented to Lender on or before the date of this Agreement. 

        2.2    Payments.    

        (a)    Scheduled Payments.    Borrower shall make payments of principal and accrued interest in advance for each Loan
(collectively, "Scheduled Payments") as set forth in the Loan Terms Schedule, commencing on the date set forth on the Loan Terms Schedule applicable to
such Loan and continuing thereafter during the Repayment Period on the first Business Day of each calendar month (each a "Payments Date"), in an amount
equal to the Loan Factor multiplied by the Loan Amount for such Loan as of such Payment Date. In any event, all unpaid principal and accrued interest shall be due and payable in full on the last
Payment Date with respect to such Loan. 

        (b)    Interim Payment.    Unless the Funding Date for a Loan is a Payment Date, Borrower shall pay the Interim
Payment payable with respect to such Loan on the Funding Date, as specified in the Loan Terms Schedule applicable to such Loan. 

        (c)    Payments of Interest.    Borrower shall pay interest on each Loan at a per annual rate of interest equal to the
Basic Rate. All computations of interest on Loans shall be based on a year of twelve 30-day months. Notwithstanding any other provision hereof, the amount of interest payable hereunder
shall not in any event exceed the maximum amount permitted by the law applicable to interest charged on commercial loans. 

        (d)    Application of Payments.    All payments received by Lender prior to an Event of Default shall be applied as
follows: (1) first, to Lender's Expenses then due and owing; and (2) second to all Scheduled Payments then due and owing, provided, however, that if such payments are not sufficient to
pay the whole amount then due, such payments shall be applied first to unpaid interest at the Basic Rate, then to the remaining amount then due. After an Event of Default, all payments and application
of proceeds shall be made as set forth in Section 9.7. 

        (e)    Default Rate.    Borrower shall pay interest at a per annum rate equal to the Default Rate on any amounts
required to be paid by Borrower under this Agreement or the other Loan Documents (including Scheduled Payments, accrued and unpaid interest, and any fees or other amounts) which remain unpaid after
such amounts are due. If an Event of Default has occurred and the Obligations have been accelerated (whether automatically or by Lender's election), Borrower shall pay interest on the aggregate,
outstanding accelerated balance hereunder from the date of the Event of Default until all Events of Default are cured, at a per annum rate equal to the Default Rate. All computations of interest at
the Default Rate shall be based on a year of twelve 30-day months. 

        2.3    Prepayments.    

        (a)    Prepayment Upon an Event of Loss.    If any Financed Equipment is subject to an Event of Loss and Borrower is
required to or elects to prepay the Loan with respect to such Financed Equipment, then such Loan shall be prepaid to the extent and in the manner provided in  Section 6.10. 

        (b)    Mandatory Prepayment Upon an Acceleration.    If the Loans are accelerated following the occurrence of an Event
of Default or otherwise (other than following an Event of Loss), then Borrower shall immediately pay to Lender (i) all accrued and unpaid Scheduled Payments with respect to each Loan due prior
to the date of prepayment, (ii) any accrued and unpaid interest, (iii) the Loan Value of each Loan, and (iv) all other sums, if any, that shall have become due and payable
hereunder. 

7

 

        (c)    Optional Prepayment.    Upon ten (10) Business Days' prior written notice to Lender, Borrower may, at
its option, at any time more than twelve (12) months after the last Funding Date on which a Loan is funded, prepay all, and not less than all, of the Loans in full by paying to Lender an amount
equal to
(i) all accrued and unpaid Scheduled Payments with respect to each Loan due prior to the date of prepayment; (ii) any accrued and unpaid interest; (iii) the Loan Value of each
Loan, and (iv) all other sums, if any, that shall have become due and payable hereunder. 

        (d)    Prepayment Upon Merger, Acquisition or Change of Ownership.    If Borrower desires to effect a merger,
acquisition or change of ownership otherwise prohibited by Section 7.6 or Section 7.7 below, and Lender, after reasonable notice and opportunity to evaluate such transaction, does not
consent to such transaction, then Borrower shall have the night, concurrent with the closing of such transaction, to prepay all, but not less than all, of the Loans in full by paying to Lender an
amount equal to: (i) all accrued and unpaid Scheduled Payments with respect to each Loan due prior to the date of prepayment; (ii) any accrued and unpaid interest; (iii) the Loan
Value of each Loan; and (iv) all other sums, if any, that shall have become due and payable hereunder. 

        (e)    No Other Prepayment.    Borrower may not prepay any Loan except as set forth in  Section 2.3(a), (b), (c) or (d)
above, in which event the prepayment shall be made as described in such sections. 

        2.4    Other Payment Terms.    

        (a)    Place and Manner.    Borrower shall make all payments due to Lender in lawful money of the United States. All
payments of principal, interest, fees and other amounts payable by Borrower hereunder shall be made, in immediately available funds not later than 10:00 a.m. California time, on the date on
which such payment is made. Borrower shall, make payments to Lender via wire transfer or by check as follows: 

	Wire Transfer Payment	 	 	 
	Credit:	 	GATX Capital Corporation
	Bank Name:	 	Bank of America
	Bank Address:	 	Dallas, Texas 75202
	Account No.:	 	3750878673
	ABA Routing No.:	 	111-000012
	Reference:	 	NuVasive Invoice #
	 	 	 	

	
Check Payment	
 	

 	

 
	Bank of America	 	 	 
	P.O. Box 198592	 	 	 
	Atlanta, GA 30384-8592	 	 	 
	Credit:	 	GATX Capital Corporation
	Reference:	 	NuVasive Invoice #
	 	 	 	

        (b)    Date.    Whenever any payment due hereunder shall fall due on a day other than a Business Day, such payment
shall be made on the next succeeding Business Day, and such extension of time shall be included in the computation of interest or fees, as the case may be. 

8

  

        2.5    Procedure for Making Loans.    

        (a)    Notice.    Whenever Borrower desires that Lender makes a Loan, Borrower shall be responsible for providing
Lender with a list of equipment proposed to be financed with such Loan together with such additional information with respect to the Loan and the Eligible Equipment and the Other Equipment as Lender
shall reasonably request. Following the receipt by Lender of such information in form and substance reasonably satisfactory to it, Lender shall notify Borrower that the conditions set forth in  Sections 3.2(b) and
3.2(c) have been met and Borrower may then notify Lender of the date on which Borrower desires Lender to make such Loan. Borrower's
notice shall be made at least five (5) Business Days in advance of the desired Funding Date, unless Lender elects at its sole discretion to allow the Funding Date to be within five
(5) Business Days of the notice. Borrower's execution and delivery to Lender of the Loan Agreement Supplement with the attached Loan Terms Schedule shall be Borrower's agreement to the terms
and calculations thereunder. Subject to the terms and conditions of this Agreement, as soon as practicable on the Funding Date specified in the Loan Terms Schedule, Lender shall transfer an amount
equal to the Loan to the account specified in the Loan Agreement Supplement in immediately available funds. Lender's obligation to make the Loan shall be expressly subject to the satisfaction of the
conditions set forth in Sections 3.1 and 3.2. 

        (b)    Loan Factor and Loan Value Calculation.    Prior to each Funding Date, Lender shall establish the Basic Rate
and the Loan Factor with respect to such Loan, which shall be set forth in the Loan Agreement Supplement to be executed by Borrower with respect to each Loan and shall be conclusive in the absence of
a manifest error. 

        (c)    Disbursement.    Lender shall disburse such Loan by wire transfer to Borrower at the account specified in the
Loan Agreement Supplement for the relevant Loan. 

        2.6    Minimum Funding Amount; Maximum Number of Fundings.    Except with the prior consent of Lender, in Lender's
sole discretion, (i) there shall not be more than one funding of a Loan in any one calendar month; and (ii) the aggregate amount of the requested Loans shall not be less than the Minimum
Funding Amount. 

        2.7    Good Faith Deposit; Facility Fee.    

        (a)    Good Faith Deposit.    Borrower has paid a good faith deposit in the amount of Ten Thousand Dollars ($10,000)
(the "Good Faith Deposit"). The Good Faith Deposit shall be used to pay Lender's Expenses in connection with its due diligence and negotiation and
documentation of this Agreement and the Loan Documents. Any remaining balance of the Good Faith Deposit shall be applied to the first Scheduled Payment due after the determination of Lender's
Expenses. It is agreed that Lender shall be entitled to retain $4,500 as payment for its legal expenses in connection with the negotiation and documentation of this Agreement and the Loan Documents. 

        (b)    Facility Fee.    Borrower shall pay concurrently with its execution and delivery of this Agreement a facility
fee in the amount of Ten Thousand Dollars ($10,000) (the "Facility Fee"). The Facility Fee shall be retained by Lender and shall be deemed fully earned
upon receipt. 

        3.    Conditions of Loans.    

        3.1    Conditions Precedent to Closing.    At the time of the execution and delivery of this Agreement, Lender shall
have received, in form and substance reasonably satisfactory to Lender, all of the following (unless Lender has agreed to waive such condition or document, in which case 

9

 

such
condition or document shall be a condition precedent to all Loans and deemed added to Section 3.2): 

        (a)   This
Agreement duly executed by Borrower and Lender. 

        (b)   The
separate Warrant to be issued to Lender or its designee, duly executed by Borrower and Lender. 

        (c)   A
certificate of the secretary or assistant secretary of Borrower with copies of the following documents attached: (i) the certificate of incorporation and bylaws
of Borrower certified by Borrower as being in full force and effect on the date thereof, (ii) incumbency and representative signatures, and (iii) resolutions authorizing the execution
and delivery of this Agreement and each of the other Loan Documents. 

        (d)   A
good standing certificate from Borrower's state of incorporation and the state in which Borrower's principal place of business is located, together with certificates
of the applicable governmental authorities stating that Borrower is in compliance with the franchise tax laws of each such state, each dated as of a recent date 

        (e)   Evidence
of the insurance coverage required by Section 6.9 of this Agreement. 

        (f)    All
necessary consents of shareholders and other third parties with respect to the execution, delivery and performance of this Agreement, the Warrant and the other Loan
Documents. 

        (g)   Such
other documents, and completion of such other matters, as Lender may reasonably deem necessary or appropriate. 

        3.2    Conditions Precedent to All Loans.    The obligation of Lender to make each Loan, including the initial Loan,
is further subject to the following conditions: 

        (a)   No
Default or Event of Default shall have occurred and be continuing. 

        (b)   Borrower
shall have provided to Lender, with respect to the Eligible Equipment which is requested to be financed with the proceeds of the Loan to be made on such Funding
Date, such invoices, purchase orders, bills of sale, serial numbers, agreements, canceled checks, and other documents as Lender shall reasonably request to evidence the ownership by Borrower of, and
the payment in full by Borrower of the purchase price of such Eligible Equipment, each in form and substance reasonably satisfactory to Lender. 

        (c)   Borrower
shall have provided to Lender, with respect to the Other Equipment which is requested to be financed with the proceeds of the Loan to be made on such Funding
Date, such invoices, purchase orders, bills of sale, agreements, canceled checks, and other documents as Lender shall reasonably request to evidence the ownership by Borrower of, and the payment in
full of the purchase price by Borrower of such Other Equipment, each in form and substance reasonably satisfactory to Lender. 

        (d)   Borrower
shall have provided Lender with the location of each item of Financed Equipment and a Landlord Agreement for each such location (unless Borrower is the fee
owner thereof) or a Service Provider's Consent if Financed Equipment is located at a third party service provider, as appropriate, which has been duly executed by each of the parties thereto. 

        (e)   Borrower
and Lender shall have executed a Loan Agreement Supplement, including a Loan Terms Schedule and a list of Financed Equipment with respect to the proposed Loan. 

        (f)    Lender
shall have received such documents, instruments and agreements, including UCC financing statements or amendments to UCC financing statements, as Lender shall 

10

 

reasonably
request to evidence the perfection and priority of the security interests granted to Lender, pursuant to Section 4. 

        (g)   Borrower
shall have delivered to Lender a release, or estoppel letter, as appropriate, from any Person having an existing Lien on any item of Eligible Equipment or Other
Equipment which is requested to be financed. 

        (h)   Such
other documents, and completion of such other matters, as Lender may reasonably deem necessary or appropriate. 

        3.3    Covenant to Deliver.    Borrower agrees (not as a condition but as a covenant) to deliver to Lender each item
required to be delivered to Lender as a condition to each Loan, if such Loan is advanced. Borrower expressly agrees that the extension of such Loan prior to the receipt by Lender of any such item
shall not constitute a waiver by Lender of Borrower's obligation to deliver such item, and any such extension in the absence of a required item shall be in Lender's sole discretion. 

        4.    Creation of Security Interest.    

        4.1    Grant of Security Interest.    Borrower grants to Lender (subject only to Permitted Liens) a valid, first
priority, continuing security interest in all presently existing and hereafter acquired or arising Collateral in order to secure prompt, full and complete payment of any and all Obligations and in
order to secure prompt, full and complete performance by Borrower of each of its covenants and duties under each of the Loan Documents. The "Collateral"
shall mean and include all right, title, interest, claims and demands of Borrower in and to all of the following: 

        All
right, title, interest, claims. and demands of Borrower in and to each and every item of goods (and embedded computer programs and supporting information included within the
definition of "goods" under the Code), equipment, fixtures or personal property, whether now owned or hereafter acquired, which is financed with or is designated as "Collateral" for the Obligations on
and after the date of this Agreement by designating such goods, equipment, fixtures and personal property on an annex or exhibit to a Loan Agreement Supplement executed by Borrower, together with all
substitutions, renewals or replacements of and additions, improvements, accessions, replacement parts and accumulations to any and all of such goods, equipment, fixtures or personal property
(collectively, the "Financed Equipment"), together with all proceeds thereof, including, without limitation, insurance, condemnation, requisition or
similar payments, and all proceeds from sales, renewals, releases or other
dispositions thereof; together with a non-exclusive, irrevocable, perpetual, fully paid, royalty-free license or other right to use, without charge, Borrower's intellectual
property now or hereafter acquired, provided, however, that such license shall only be exercisable to the extent necessary or appropriate in connection with the disposition of Collateral upon Lender's
exercise of its remedies hereunder. 

        4.2    After-Acquired Property.    All Financed Equipment which is financed through Loans and any and all other
Property generally described or referred to as Collateral or Financed Equipment which is hereafter acquired by Borrower shall ipso facto, and without any further conveyance, assignment or act on the
part of Borrower or Lender, become and be subject to the security interest herein granted as fully and completely as though specifically described herein. The list of Financed Equipment shall be
amended and supplemented on each Funding Date by a Loan Agreement Supplement to incorporate all Financed Equipment financed with the Loan advanced on such Funding Date; provided, however, the failure
to so amend and supplement the list of Financed Equipment shall not affect the grant by Borrower to Lender of the security interest in such Financed Equipment pursuant to this  Section 4. This
Agreement and the other documents in connection herewith may be otherwise supplemented and amended from time to time, as required 

11

 

by
Lender, to reflect additional Collateral to be subject to the security interest granted pursuant to this Section 4. 

        4.3    Duration of Security Interest.    Lender's security interest in the Collateral shall continue until the payment
in full and the satisfaction of all Obligations and termination of the Commitments, whereupon such security interest shall terminate; provided, however, if any item of Financed Equipment is subject to
an Event of Loss, then following the prepayment of the Loan with respect to such item pursuant to Section 2.3, Lender shall release its security
interest in such item of Financed Equipment. Lender shall, at Borrower's sole cost and expense, execute such further documents and take such further actions as may be reasonably necessary to effect
the release contemplated by this Section 4.3, including duly executing and delivering termination statements for filing in all relevant
jurisdictions under the Code. 

        4.4    Location and Possession of Collateral.    The Collateral is and shall remain in the possession of Borrower at
its location listed on the cover page hereof, or if Lender subsequently agrees to any additional location, as set forth in a Loan Agreement Supplement. Borrower shall remain in full possession,
enjoyment and control of the Collateral (except only as may be otherwise required by Lender for perfection of its security interest therein) and so long as no Event of Default has occurred, shall be
entitled to manage, operate and use the same and each part thereof with the rights and franchises appertaining thereto; provided,  however, that the
possession enjoyment, control and use of the Collateral shall at all time be subject to the observance and performance of the terms of
this Agreement. 

        4.5    Markings on the Collateral.    At Lender's request at any time during the Term of the Loan (including any
extension thereof), Borrower shall place in a conspicuous location on each item of Financed Equipment a plaque or other marking to be supplied by Lender which reads substantially as follows: 

GATX VENTURES, INC., Lienholder.  

        Such
plaque or other marking shall not be removed (or if removed or damaged such plaque or other marking shall be replaced) until the security interest in favor of Lender in such item of
Collateral is terminated pursuant to this Agreement. 

        4.6    Delivery of Additional Documentation Required.    Borrower shall from time to time execute and deliver to
Lender, at the request of Lender, all financing statements and other documents Lender may reasonably request, in form satisfactory to Lender, to perfect and continue Lender's perfected security
interests in the Collateral and in order to consummate fully all of the transactions contemplated under the Loan Documents. 

        4.7    Right to Inspect.    Lender (through any of its officers, employees, or agents) shall have the right, upon
reasonable prior notice, from time to time during Borrower's usual business hours, to inspect Borrower's books and records and to make copies thereof and to inspect, test, and appraise the Collateral
in order to verify Borrower's financial condition or the amount, condition of, or any other matter relating to, the Collateral. 

        5.    Representations and Warranties.    Except as set forth in the Disclosure Schedule, Borrower represents, warrants
and covenants as follows: 

        5.1    Organization and Qualification.    Borrower is a corporation duly organized and validly existing and in good
standing under the laws of its state of incorporation and qualified and licensed (if any licenses are required for the operation of Borrower's business) to do business in, and is in good standing in,
any state in which the conduct of its business or its ownership of Property requires that it be so qualified or in which the Collateral is located, except for such states 

12

 

as
to which any failure to so qualify would not have a material adverse effect on Borrower. Borrower has no Subsidiaries. 

        5.2    Authority.    Borrower has all necessary power and authority to execute, deliver, and perform in accordance
with the terms thereof, the Loan Documents to which it is a party. Borrower has all requisite power and authority to own and operate its Property and to carry on its businesses as now conducted. 

        5.3    Conflict with Other Instruments, etc.    Neither the execution and delivery of any Loan Document to which
Borrower is a party nor the consummation of the transactions therein contemplated nor compliance with the terms, conditions and provisions thereof will materially conflict with or result in any
material breach of any of the terms, conditions or provisions of the certificate of incorporation and the by-laws, or other organizational documents of Borrower or any law or any
regulation, order, writ, injunction or decree of any court or governmental instrumentality or any material agreement or instrument to which Borrower is a party or by which it or any of its Property is
bound or to which it or any of its Property is subject, or constitute a default thereunder or result in the creation or imposition of any Lien, other than Permitted Liens. 

        5.4    Authorization, Enforceability.    The execution and delivery of this Agreement, the granting of the security
interest in the Collateral, the incurring of the Loans, the execution and delivery of the other Loan Documents to which Borrower is a party and the consummation of the transactions herein and therein
contemplated have each been duly authorized by all necessary action on the part of Borrower. The Loan Documents have been duly executed and delivered and constitute legal, valid and binding
obligations of Borrower, enforceable in accordance with their respective terms, except as the enforceability thereof may be limited by bankruptcy, insolvency or other similar laws of general
application relating to or affecting the enforcement of creditors' rights or by general principles of equity. 

        5.5    No Prior Encumbrances.    Borrower has good and marketable title to the Collateral, free and clear of Liens
except for Permitted Liens. 

        5.6    Name; Location of Chief Executive Office, Principal Place of Business and Collateral.    Borrower has not done
business under any name other than that specified on the signature page hereof. The chief executive office, principal place of business, and the place where Borrower maintains its records concerning
the Collateral are presently located at the address set forth on the cover page of this Agreement. The Collateral is presently located at the address set forth on the cover page hereof, or if Lender
subsequently agrees to any other locations, as set forth in a Loan Agreement Supplement which is executed by Lender. 

        5.7    Litigation.    There are no actions or proceedings pending by or against Borrower before any court or
administrative agency in which an adverse decision could have a material adverse effect on Borrower or the aggregate value of the Collateral. Borrower does not have knowledge of any such pending or
threatened actions or proceedings. Borrower will promptly notify Lender in writing if any action, proceeding or governmental investigation involving Borrower is commenced that is reasonably expected
to result in damages or costs to Borrower of Fifty Thousand Dollars ($50,000) or more. 

        5.8    Financial Statements.    All financial statements relating to Borrower or any Affiliate that have been or may
hereafter be delivered by Borrower to Lender present fairly in all material respects Borrower's financial condition as of the date thereof and Borrower's results of operations for the period then
ended. 

        5.9    Security Interest.    Assuming the proper filing of one or more financing statement(s) identifying the
Collateral with the proper federal, state and/or local authorities, the security interests in the Collateral granted to Lender pursuant to this Agreement (i) constitute and will 

13

 

continue
to constitute first priority security interests (except to the extent any Permitted Liens may have a superior priority to Lender's Lien under this Agreement) and (ii) are and will
continue to be superior and prior to the rights of all other creditors of Borrower (except to the extent of such Permitted Liens). 

        5.10    No Material Adverse Effect.    No event has occurred and no condition exists which could reasonably be
expected to have a material adverse effect on the financial condition, business or operations of Borrower since [insert date of last audited financials]. 

        5.11    Full Disclosure.    No representation, warranty or other statement made by Borrower in any Loan Document
(including the Disclosure Schedule), certificate or written statement furnished to Lender contains, as of the date such representation, warranty or other statement is made, any untrue statement of a
material fact or omits to state a material fact necessary in order to make the statements contained in such certificates or statements not misleading. There is no fact known to Borrower which
materially adversely affects, or which could in the future be reasonably expected to materially adversely affect, its ability to perform its obligations under this Agreement. 

        5.12    Solvency, Etc.    Borrower is Solvent (as defined below) and, after the execution and delivery of the Loan
Documents and the consummation of the transactions contemplated thereby, Borrower will be Solvent. "Solvent" shall mean, with respect to any Person on
any date, that on such date (a) the fair value of the property of such Person is greater than the fair value of the liabilities (including, without limitation, contingent liabilities) of such
Person, (b) the present fair saleable value of the assets of such Person is not less than the amount that will be required to pay the probable liability of such Person on its debts as they
become absolute and matured, (c) such Person does not intend to, and does not believe that it will, incur debts or liabilities beyond such Person's ability to pay as such debts and liabilities
mature and (d) such Person is not engaged in business or a transaction, and is not about in business or a transaction, for which such Person's property would constitute an unreasonably small
capital. 

        6.    Affirmative Covenants.    Borrower covenants and agrees that, until the full and complete payment of the
Obligations, Borrower shall do all of the following: 

        6.1    Good Standing.    Borrower shall maintain its corporate existence and its good standing in its jurisdiction of
incorporation and maintain qualification in each jurisdiction in which the failure to so qualify could reasonably be expected to have a material adverse effect on the financial condition, operations
or business of Borrower. Borrower shall maintain in force all licenses, approvals and agreements, the loss of which could reasonably be expected to have a material adverse effect on its financial
condition, operations or business. 

        6.2    Government Compliance.    Borrower shall comply with all statutes, laws, ordinances and government rules and
regulations to which it is subject, noncompliance with which could reasonably be expected to materially adversely affect the financial condition, operations or business of Borrower. 

        6.3    Financial Statements, Reports, Certificates.    Borrower shall deliver to Lender: (a) as soon as
available, but in any event within thirty (30) days after the end of each month, a company prepared balance sheet, income statement and cash flow statement covering Borrower's operations during
such period; (b) as soon as available, but in any event within one-hundred twenty (120) days after the end of Borrower's fiscal year, audited financial statements of Borrower
prepared in accordance with GAAP, together with an opinion on such financial statements of a nationally recognized or other independent public accounting firm reasonably acceptable to Lender; and
(c) such other financial information as Lender may reasonably request from time to time. From and after such time as Borrower becomes a publicly reporting company, promptly as they are
available and in any event: (x) at the time of filing of Borrower's Form 10-K with the 

14

 

Securities
and Exchange Commission after the end of each fiscal year of Borrower, the financial statements of Borrower filed with such Form 10-K; and (y) at the time of
filing of Borrower's Form 10-Q with the Securities and Exchange Commission after the end of each of the first three fiscal quarters of Borrower, the financial statements of Borrower
filed with such Form 10-Q. In addition, Borrower shall deliver to Lender (i) promptly upon becoming available, copies of all statements, reports and notices sent or made
available generally by Borrower to its security holders; (ii) immediately upon receipt of notice thereof, a report of any material legal actions pending or threatened against Borrower; and
(iii) such other financial information as Lender may reasonably request from time to time. 

        6.4    Certificates of Compliance.    Each time financial statements are furnished pursuant to  Section 6.3 above, there shall
be delivered to Lender an Officer's Certificate signed by the president, treasurer or chief financial officer of
Borrower (a "Responsible Officer") in the form of, and certifying to the matters set forth in, Exhibit G hereto. 

        6.5    Notice of Event of Loss.    As soon as possible, and in any event within ten (10) days after Borrower
has knowledge thereof, Borrower shall notify Lender in writing in reasonable detail of any Event of Loss. 

        6.6    Notice of Defaults.    As soon as possible, and in any event within five (5) days after the discovery of
a Default or an Event of Default, provide Lender with an Officer's Certificate of Borrower setting forth the facts relating to or giving rise to such Default or Event of Default and the action which
Borrower proposes to take with respect thereto. 

        6.7    Taxes.    Borrower shall make due and timely payment or deposit of all federal, state, and local taxes,
assessments, or contributions required of it by law or imposed upon any Property belonging to it, including the Financed Equipment, and will execute and deliver to Lender, on demand, appropriate
certificates attesting to the payment or deposit thereof; and Borrower will make timely payment or deposit of all tax payments and withholding taxes required of it by applicable laws, including those
laws concerning F.I.C.A., F.U.T.A., state disability, and local, state, and federal income taxes, and will, upon request, furnish Lender with proof satisfactory to Lender indicating that Borrower has
made such payments or deposits; provided that Borrower need not make any payment if the amount or validity of such payment is contested in good faith by appropriate proceedings which suspend the
collection thereof (provided, however, that such proceedings do not involve any substantial danger of
the sale, forfeiture or loss of any item of Financed Equipment, any material item of Collateral or Collateral which in the aggregate is material to Borrower and that Borrower has adequately bonded
such amounts or reserves sufficient to discharge such amounts have been provided on the books of Borrower). 

        6.8    Use; Maintenance.    

        (a)   Borrower,
at its expense, shall make all necessary site preparations and cause the Collateral to be operated in accordance with any applicable manufacturer's manuals or
instructions. So long as no Default or Event of Default has occurred, Borrower shall have the right to quietly possess and use the Collateral as provided herein without interference by Lender. 

        (b)   Borrower,
at its expense, shall maintain the Collateral in good condition, reasonable wear and tear excepted, and will comply in all material respects with all laws,
rules and regulations to which the use and operation of the Collateral may be or become subject. Such obligation shall extend to repair and replacement of any partial loss or damage to the Collateral
which does not constitute an Event of Loss, regardless of the cause. If maintenance is mandated by manufacturer, Borrower shall obtain and keep in effect, at all times during the Term maintenance
service contracts with suppliers approved by Lender, such approval not to 

15

 

be
unreasonably withheld. All parts furnished in connection with such maintenance or repair shall immediately become part of the Collateral. All such maintenance, repair and replacement services shall
be immediately paid for and discharged by Borrower with the result that no Lien will attach to the Collateral. 

        6.9    Insurance.    Borrower shall, obtain and maintain for the Term, at its own expense: 

        (a)   "All
risk" insurance against loss or damage to the Collateral. The coverage limit shall be the greater of the replacement cost of the Equipment or the Loan Value
applicable to each Loan. The deductible shall not exceed $25,000. The policy shall name Lender, as sole loss payee with respect to the Collateral, shall not be invalidated by any action of or breach
of warranty by Borrower of any provision thereof and waive subrogation against Lender. 

        (b)   Commercial
general liability insurance (including contractual liability, products liability and completed operations coverages) reasonably satisfactory to Lender. The
limit of liability shall be at least $3,000,000 per occurrence. The policy shall be without deductible, except for products liability coverage which may have a deductible up to $25,000. The
policy(ies) shall name Lender as additional insured in the full amount of Borrower's liability coverage limits (or the coverage limits of any successor to Borrower or such successor's parent which is
providing coverage), be primary and without contribution as respects any insurance carried by Lender and contain cross liability and severability of interest clauses. 

        (c)   Such
other insurance against risks of loss and with terms as shall be reasonably required by Lender. 

        All
policies of insurance shall be placed with financially sound, commercial insurers reasonably satisfactory to Lender. All policies of insurance shall provide that Lender shall be
given 30 days' notice of cancellation of coverage. This notice provision shall be without qualification. On or prior to the first Funding Date and prior to each policy renewal, Borrower shall
furnish to Lender, certificates of insurance or other evidence satisfactory to Lender that insurance complying with all of the above requirements is in effect. 

        6.10    Loss; Damage; Destruction and Seizure.    

        (a)   Borrower
shall bear the risk of the Financed Equipment being lost, stolen, destroyed, damaged beyond repair, rendered permanently unfit for use, or seized by a
Governmental Authority for any reason whatsoever at any time until the expiration or termination of the Term. 

        (b)   If
during the Term any item of Financed Equipment is lost, stolen, destroyed, damaged beyond repair, rendered permanently unfit for use, or seized by a Governmental
Authority for any reason whatsoever for a period equal to at least the remainder of the Term (an "Event of Loss"), then in each case Lender shall
receive from the proceeds of insurance maintained pursuant to Section 6.9, from any award paid by the seizing Governmental Authority or, to the
extent not received from the proceeds of insurance or award or both, from Borrower, on or before the Payment Date next succeeding such Event of Loss, an amount equal to the sum of: (i) all
accrued and unpaid Scheduled Payments with respect to such Loan due prior to the next such Payment Date, (ii) an amount equal to the Loan Value with respect to such Loan multiplied by the
aggregate Stated Cost of each affected item of Financed Equipment divided by the Loan Amount, and (iii) all other sums, if any, that shall have become due and payable hereunder with respect to
such Loan, including interest at the Default Rate with respect to any past due amounts. On the date of receipt by Lender the amount specified above with respect to each such item of Financed Equipment
subject to an Event of Loss, this Agreement shall terminate as to such Financed Equipment. Except as provided in Section 6.10(c), any proceeds of
insurance maintained by Borrower pursuant to 

16

 

 Section 6.9 and received by Borrower shall be paid to Lender promptly upon their receipt by Borrower. If any proceeds of insurance or awards received from governmental
authorities are in excess of the amount owed under this Section 6.10, Lender shall promptly remit to Borrower the amount in excess of the amount
owed to Lender. 

        (c)   So
long as no Event of Default has occurred, any proceeds of insurance maintained pursuant to Section 6.9 received
by Lender or Borrower with respect to an item of Financed Equipment, the repair of which is practicable, shall, at the election of Borrower, be applied either to the repair or replacement of such
Financed Equipment or, upon Lender's receipt of evidence of the repair or replacement of the Financed Equipment reasonably satisfactory to Lender, to the reimbursement of Borrower for the cost of such
repair or replacement. All replacement parts and equipment acquired by Borrower in replacement of Financed Equipment pursuant to this  Section 6.10(c) shall immediately become part of the Financed
Equipment upon acquisition by Borrower. Borrower shall take such actions and
provide such documentation as may be reasonably requested by Lender to protect and preserve its first priority security interest and otherwise to avoid any impairment of Lender's rights under the Loan
Documents in connection with such repair or replacement. 

        6.11    Further Assurances.    At any time and from time to time Borrower shall execute and deliver such further
instruments and take such further action as may reasonably be requested by Lender to effect
the purposes of this Agreement, including without limitation, the continued perfection and priority of Lender's security interest in the Collateral. 

        7.    Negative Covenants.    Borrower covenants and agrees that until the full and complete payment of the
Obligations, Borrower will not do any of the following: 

        7.1    Chief Executive Office.    Change its name, chief executive office, principal place of business or any of the
items set forth in Section 1 of the Disclosure Schedule without thirty (30) days' prior written notice to Lender. 

        7.2    Collateral Control.    Subject to its rights under  Section 4, (i) terminate, waive or release any material right
with respect to any Collateral, (ii) remove any items of Collateral
from Borrower's facility located at the address set forth on the cover page hereof or such other address agreed to in writing by Lender, or (iii) affix or attach or permit to be affixed or
attached to any item of Collateral any other item of property owned by Borrower or any other lender, lesser or financing party which is not readily identifiable or separable without any damage to such
item of Collateral, without Lender's prior written consent. 

        7.3    Liens.    Create, incur, assume or suffer to exist any Lien of any kind upon any Collateral, whether now owned
or hereafter acquired, except Permitted Liens. 

        7.4    Other Dispositions of Collateral.    Convey, sell, lease or otherwise dispose of (collectively, a "Transfer")
all or any part of the Collateral to any Person except for Transfers of Financed Equipment in which Lender shall have released its security interest pursuant to  Section 4.3. 

        7.5    Distributions.    (i) Pay any dividends or make any distributions on its Equity Securities;
(ii) purchase, redeem, retire, decease or otherwise acquire for value any of its Equity Securities (other than repurchases pursuant to the terms of employee stock purchase plans, employee
restricted stock agreements or similar arrangements in an aggregate amount not to exceed $100,000); (iii) return any capital to any holder of its Equity Securities as such; (iv) make any
distribution of assets, Equity Securities, obligations or securities to any holder of its Equity Securities as such; or (v) set apart any sum for any such purpose; provided, however, that
Borrower may pay dividends payable solely in common stock. 

17

  

        7.6    Mergers or Acquisitions.    Merge or consolidate with or into any other Person or acquire all or substantially
all of the capital stock or assets of another Person. 

        7.7    Change in Ownership.    Engage in or permit any of its Subsidiaries to engage in any business other than the
businesses currently engaged in by Borrower or reasonably related thereto or have a material change in its ownership of greater than 25% (other than by the sale of Borrower's Equity Securities in a
public offering or to venture capital investors so long as Borrower identifies the venture capital investors prior to the closing of the investment). 

        7.8    Transactions With Affiliates.    Enter into any contractual obligation with any Affiliate or engage in any
other transaction with any Affiliate except upon terms at least as favorable to Borrower as an arms-length transaction with Persons who are not Affiliates of Borrower. 

        7.9    Indebtedness Payments.    (i) Prepay, redeem, purchase, decease or otherwise satisfy in any manner prior
to the scheduled repayment thereof any Indebtedness for borrowed money (other than amounts due under this Agreement) or lease obligations, (ii) amend, modify or otherwise change the terms of
any Indebtedness for borrowed money or lease obligations so as to accelerate the scheduled repayment thereof or (iii) repay any notes to officers, directors or shareholders; provided, however,
that Borrower shall not be prohibited from prepaying, redeeming or otherwise satisfying any Indebtedness or lease obligations or repaying any notes to the extent the same is accomplished by the
conversion of such obligations into equity securities of Borrower. 

        7.10    Indebtedness.    Create, incur, assume or permit to exist any Indebtedness except Permitted Indebtedness. 

        7.11    Compliance.    Become an "investment company" or a company controlled by an "investment company," under the
Investment Company Act of 1940 or undertake as one of its important activities extending credit to purchase or carry margin stock, or use the proceeds of any Loan for that purpose; fail to meet the
minimum funding requirements of the Employment Retirement Income Security Act of 1974, and its regulations, as amended from time to time ("ERISA"),
permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; fail to comply with the Federal Fair Labor Standards Act or violate any other law or regulation, if the violation
could reasonably be expected to have a material adverse effect on Borrower's business or operations or could reasonably be expected to cause a material adverse change, or permit any of its
Subsidiaries to do so. 

        8.    Events of Default.    Any one or more of the following events shall constitute an "Event of Default" by Borrower
under this Agreement: 

        8.1   If
Borrower fails to pay when due and payable or when declared due and payable in accordance with the Loan Documents: (i) any Scheduled Payment on the relevant
Payment Date; or (ii) any other portion of the Obligations within five (5) days after receipt of written notice from Lender that such payment is due. 

        8.2   If
Borrower fails to perform any obligation under Sections 6.9 or 6.10 or violates any of the covenants contained in  Section 7 of this Agreement.

        8.3   If
Borrower fails or neglects to perform, keep, or observe any other material term, provision, condition, covenant, or agreement contained in this Agreement (other than
as set forth in Sections 8.1, 8.2 or 8.4 through 8.13), in any of the other Loan Documents and Borrower has failed to cure such default within fifteen
(15) days of the occurrence of such default. During this 15-day period, the failure to cure the default is not an Event of Default (but no Loans will be made during the cure
period). 

18

 

        8.4   If
there occurs a material adverse change in Borrower's business, or if there is a material impairment of the prospect of repayment of any portion of the Obligations
owing to Lender or a material impairment of the value or priority of Lender's security interest in the Collateral. 

        8.5   If
any material portion of Borrower's assets is attached, seized, subjected to a writ or distress warrant, or is levied upon, or comes into the possession of any
trustee, receiver or Person acting in a similar capacity and such attachment, seizure, writ or distress warrant or levy has not been removed, discharged or rescinded within ten (10) days, or if
Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct all or any material part of its business affairs, or if a judgment or other claim becomes a lien or
encumbrance upon any material portion of Borrower's assets, or if a notice of lien, levy, or assessment is filed of record with respect to any of Borrower's assets by the United States Government, or
any department, agency, or instrumentality thereof, or by any state, county, municipal, or governmental agency, and the same is not paid within ten (10) days after Borrower receives notice
thereof, provided that none of the foregoing shall constitute an Event of Default where such action or event is stayed or an adequate bond has been posted pending a good faith contesting by Borrower. 

        8.6   The
service of process upon any Lender seeking to attach by a trustee or other process any funds of the Borrower on deposit or otherwise held by Lender, or the delivery
upon Lender of a notice of foreclosure by any Person seeking to attach or foreclose on any funds of the Borrower on deposit or otherwise held by Lender, or the delivery of a notice of foreclosure or
exclusive control to any entity holding or maintaining Borrower's deposit accounts or accounts holding securities by any Person (other than Lender) seeking to foreclose or attach any such accounts or
securities. 

        8.7   One
or more defaults shall exist under any agreements with any third party or parties which consists of the failure to pay any Indebtedness at maturity or which results
in a right by such third party or parties, whether or not exercised, to accelerate the maturity of Indebtedness of Borrower in an aggregate amount in excess of One Hundred Thousand Dollars ($100,000)
or a default shall exist under any financing agreement with Lender or any of Lender's Affiliates. 

        8.8   If
a judgment or judgments for the payment of money in an amount, individually or in the aggregate, of at least One Hundred Thousand Dollars ($100,000) shall be rendered
against Borrower and shall remain unsatisfied and unstayed for a period of ten (10) days or more. 

        8.9   If
any material misrepresentation or material misstatement exists now or hereafter in any warranty, representation, statement, certification, or report made to Lender by
Borrower or any officer, employee, agent, or director of Borrower. 

        8.10    If
Borrower shall breach any term of the Warrant. 

        8.11    If
any Loan Document shall in any material respect cease to be, or Borrower shall assert that any Loan Document is not, a legal, valid and binding obligation of
Borrower enforceable in accordance with its terms. 

        8.12    If
a proceeding shall have been instituted in a court having jurisdiction in the premises seeking a decree or order for relief in respect of Borrower in an involuntary
case under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, or for the appointment of a receiver, liquidator, assignee, custodian, trustee (or similar official)
of Borrower or for any substantial part of its property, or for the winding-up or liquidation of its affairs, and such proceeding shall remain undismissed or unstayed and in effect for a
period of thirty (30) consecutive days or such court shall enter a decree or order granting the relief sought in such proceeding. 

19

 

        8.13    If
Borrower shall commence a voluntary case under any applicable bankruptcy, insolvency or other similar law now or hereafter in effect, shall consent to the entry of
an order for relief in an involuntary case under any such law, or shall consent to the appointment of or taking possession by a receiver, liquidator, assignee, trustee, custodian (or other similar
official) of Borrower or for any substantial part of its property, or shall make a general assignment for the benefit of creditors, or shall fail generally to pay its debts as they become due, or
shall take any corporate action in furtherance of any of the foregoing. 

        9.    Lender's Rights and Remedies.    

        9.1    Rights and Remedies.    Upon the occurrence of any Default or Event of Default, Lender shall not have any
further obligation to advance money or extend credit to or for the benefit of Borrower. In addition, upon the occurrence of an Event of Default, Lender shall have the rights, options, duties and
remedies of a secured party as permitted by law and, in addition to and without limitation of the foregoing, Lender may, at its election, without notice of election and without demand, do any one or
more of the following, all of which are authorized by Borrower: 

        (a)   Declare
all Obligations, whether evidenced by this Agreement, by any of the other Loan Documents, or otherwise, including (i) all accrued and unpaid Scheduled
Payments with respect to each Loan, (ii) any accrued and unpaid interest, (iii) the Loan Value with respect to each Loan, and (iv) all other sums, if any, that shall have become
due and payable hereunder, immediately due and payable (provided that upon the occurrence of an Event of Default described in Section 8.12 or
8.13 all Obligations shall become immediately due and payable without any action by Lender); 

        (b)   Make
such payments and do such acts as Lender considers necessary or reasonable to protect Lender's security interest in the Collateral. Borrower agrees to assemble the
Collateral if Lender so requires, and to make the Collateral available to Lender as Lender may designate. Borrower authorizes Lender to enter the premises where the Collateral is located, to take and
maintain possession of the Collateral, or any part of it, and to pay, purchase, contest, or compromise any Lien which in Lender's determination appears or is claimed to be prior or superior to their
security interest and to pay all expenses incurred in connection therewith. With respect to any of Borrower's owned premises, Borrower hereby grants Lender a license to enter into possession of such
premises and to occupy the same, without charge, for up to one hundred twenty (120) days in order to exercise any of Lender's rights or remedies provided herein, at law, in equity, or
otherwise; 

        (c)   Ship,
reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell (in the manner provided for herein) the Collateral. Lender and
its agents and any purchasers at or after foreclosure are hereby granted a non-exclusive, irrevocable, perpetual, fully paid, royalty-free license or other right, solely
pursuant to the provisions of this Section 9.1, to use, without charge, Borrower's intellectual property, including without limitation, labels,
patents, copyrights, rights of use of any name, trade secrets, trade names, trademarks, service marks, and advertising matter, or any Property of a similar nature, now or at any time hereafter owned
or acquired by Borrower or in which Borrower now or at any time hereafter has any rights, provided, however, that
such license shall only be exercisable in connection with the disposition of Collateral upon Lender's exercise of its remedies hereunder; 

        (d)   Sell
the Collateral at either a public or private sale, or both, by way of one or more contracts or transactions, for cash or on terms, in such manner and at such places
(including Borrower's premises) as Lender determines are commercially reasonable; and 

        (e)   Credit
bid and purchase all or any portion of the Collateral at any public sale. 

20

 

        Any
deficiency that exists after disposition of the Collateral as provided above will be paid immediately by Borrower. 

        9.2    Set Off Right.    Upon an Event of Default, Lender may set off and apply to the Obligations any and all
indebtedness at any time owing to or for the credit or the account of Borrower. 

        9.3    Effect of Sale.    Any sale, whether under any power of sale hereby given or by virtue of judicial proceedings,
shall operate to divest all right, title, interest, claim and demand whatsoever, either at law or in equity, of Borrower in and to the Property sold, and shall be a perpetual bar, both at law and in
equity, against Borrower, its successors and assigns, and against any and all Persons claiming the Property sold or any part thereof under, by or through Borrower, its successors or assigns. 

        9.4    Power of Attorney in Respect of the Collateral.    Borrower does hereby irrevocably appoint Lender (which
appointment is coupled with an interest), the true and lawful attorney in fact of Borrower with full power of substitution, for it and in its name to file any notices of security interests, financing
statements and continuations and amendments thereof pursuant to the Code or federal law, as may be necessary to perfect, or to continue the perfection of Lender's security interests in the Collateral.
Borrower does hereby irrevocably appoint Lender (which appointment is coupled with an interest) on the occurrence of an Event of Default, the true and lawful attorney in fact of Borrower with full
power of substitution, for it and in its name: (a) to ask, demand, collect, receive, receipt for, sue for, compound and give acquaintance for any and all rents, issues, profits, avails,
distributions, income, payment draws and other sums in which a security interest is granted under Section 4 with full power to settle, adjust or
compromise any claim thereunder as fully as if Lender were a Borrower itself, (b) to receive payment of and to endorse the name of Borrower to any items of Collateral (including checks, drafts
and other orders for the payment of money) that come into Lender's possession or under Lender's control, (c) to make all demands, consents and waivers, or take any other action with respect to,
the Collateral, (d) in Lender's discretion to file any claim or take any other action or proceedings, either in its own name or in the name of Borrower or otherwise, which Lender may reasonably
deem
necessary or appropriate to protect and preserve the right, title and interest of Lender in and to the Collateral, (e) endorse Borrower's name on any checks or other forms of payment or
security; (f) sign Borrower's name on any invoice or bill of lading for any account or drafts against account debtors, (g) make, settle, and adjust all claims under Borrower's insurance
policies; (h) settle and adjust disputes and claims about the accounts directly with account debtors, for amounts and on terms Lender determines reasonable; (i) transfer the Collateral
into the name of Lender or a third party as the Code permits, or (j) to otherwise act with respect thereto as though Lender were the outright owner of the Collateral. 

        9.5    Lender's Expenses.    If Borrower fails to pay any amounts or furnish any required proof of payment due to
third persons or entities, as required under the terms of this Agreement, then Lender may do any or all of the following: (a) make payment of the same or any part thereof; or (b) obtain
and maintain insurance policies of the type discussed in Section 6.9 of this Agreement, and take any action with respect to such policies as
Lender deems prudent. Any amounts paid or deposited by Lender shall constitute Lender's Expenses, shall be immediately due and payable, and shall bear interest at the then applicable rate hereinabove
provided, and shall be secured by the Collateral. Any payments made by Lender shall not constitute an agreement by Lender to make similar payments in the future or a waiver by Lender of any Event of
Default under this Agreement. Borrower shall pay all reasonable fees and expenses, including without limitation, Lender's Expenses incurred by Lender in the enforcement or attempt to enforce any of
the Obligations hereunder not performed when due. 

21

 

        9.6    Remedies Cumulative.    Lender's rights and remedies under this Agreement, the Loan Documents, and all other
agreements shall be cumulative. Lender shall have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise by Lender of one right or remedy
shall be deemed an election, and no waiver by Lender of any Event of Default on Borrower's part shall be deemed a continuing waiver. No delay by Lender shall constitute a waiver, election, or
acquiescence by it. 

        9.7    Application of Collateral Proceeds.    The proceeds and/or avails of the Collateral, or any part thereof, and
the proceeds and the avails of any remedy hereunder (as well as any other amounts of any kind held by Lender at the time of or received by Lender, after, the occurrence of an Event of Default
hereunder) shall be paid to and applied as follows: 

        (a)   First,
to the payment of out-of-pocket costs and expenses, including all amounts expended to preserve the value of the Collateral, of foreclosure
or suit, if any, and of such sale and the exercise of any other rights or remedies, and of all proper fees, expenses, liability and advances, including reasonable legal expenses and attorneys' fees,
incurred or made hereunder by Lender, including without limitation, Lender's Expenses; 

        (b)   Second,
to the payment to Lender of the amount then owing or unpaid on the Loans for Scheduled Payments, any accrued and unpaid interest, the Loan Value of the Loans,
and all other Obligations with respect to all Loans, provided, however, that if such proceeds shall be insufficient to pay in full the whole amount so due, owing or unpaid upon the Loans, then to the
unpaid interest thereon, then to the Loan Value of the Loans, and then to the payment of other amounts then payable to Lender under any of the Loan Documents; and 

        (c)   Third,
to the payment of the surplus, if any, to Borrower, its successors and assigns, or to whomsoever may be lawfully entitled to receive the same. 

        9.8    Reinstatement of Rights.    If Lender shall have proceeded to enforce any right under this Agreement or any
other Loan Document by foreclosure, sale, entry or otherwise, and such proceedings shall have been discontinued or abandoned for any reason or shall have been determined adversely, then and in every
such case (unless otherwise ordered by a court of competent jurisdiction), Lender shall be restored to its former position and rights hereunder with respect to the Property subject to the security
interest created under this Agreement. 

        10.    Waivers; Indemnification.    

        10.1    Demand; Protest.    Borrower waives demand, protest, notice of protest, notice of default or dishonor, notice
of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees at
any time held by Lender on which Borrower may in any way be liable. 

        10.2    Lender's Liability for Collateral.    So long as Lender complies with its obligations, if any, under the Code,
Lender shall not in any way or manner be liable or responsible for: (a) the safekeeping of the Collateral; (b) any loss or damage thereto occurring or arising in any manner or fashion
from any cause other than Lender's gross negligence or willful misconduct; (c) any diminution in the value thereof or (d) any act or default of any carrier, warehouseman, bailee,
forwarding agency, or other Person whomsoever. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 

        10.3    Indemnification and Waiver.    Whether or not any Loans are made hereunder: 

        (a)    General Indemnity.    Borrower agrees upon demand to pay or reimburse Lender for all liabilities, obligations
and out-of-pocket expenses, including Lender's Expenses and reasonable fees and expenses of counsel for Lender, from time to time arising in connection with the enforcement or
collection of sums due under the Loan Documents, and in 

22

 

connection
with any amendment or modification of the Loan Documents or any "work-out" in connection with the Loan Documents. Borrower shall indemnify, reimburse and hold Lender and each of
its respective successors, assigns, agents, attorneys, officers, directors, shareholders, servants, agents and employees (each an "Indemnified Person")
harmless from and against all liabilities, losses, damages, actions, suits, demands, claims of any kind and nature (including claims relating to environmental discharge, cleanup or compliance), all
costs and expenses whatsoever to the extent they may be incurred or suffered by such Indemnified Person in connection therewith (including reasonable attorneys' fees and expenses), fines, penalties
(and other charges of applicable governmental authorities), licensing fees relating to any item of Collateral, damage to or loss of use of property (including consequential or special damages to third
parties or damages to Borrower's property), or bodily injury to or death of any person (including any agent or employee of Borrower) (each, a "Claim"),
directly or indirectly relating to or arising out of the use of the proceeds of the Loans or otherwise, the falsity of any representation or warranty of Borrower or Borrower's failure to comply with
the terms of this Agreement or any other Loan Document during the Term. The foregoing indemnity shall cover, without limitation, (i) any Claim in connection with a design or other defect
(latent or patent) in any item of equipment included in the Collateral, (ii) any Claim for infringement of any patent, copyright, trademark or other intellectual property right,
(iii) any Claim resulting from the presence on or under or the escape, seepage, leakage, spillage, discharge, emission or release of any Hazardous Materials on the premises owned, occupied or
leased by Borrower, including any Claims asserted or arising under any Environmental Law, (iv) any Claim for negligence or strict or absolute liability in tort, or (v) any Claim asserted
as to or arising under any Landlord Agreement or any Service Provider's Consent; provided, however, that
Borrower shall not indemnify any Indemnified Person for any liability incurred by such Indemnified Person as a direct and sole result of such Indemnified Person's gross negligence or willful
misconduct. Such indemnities shall continue in full force and effect, notwithstanding the expiration or termination of this Agreement. Upon Lender's written demand, Borrower shall assume and
diligently conduct, at its sole cost and expense, the entire defense of Lender, each of its partners, and each of their respective, agents, employees, directors, officers, shareholders, successors and
assigns against any indemnified Claim described in this Section 10.3. Borrower shall not settle or compromise any Claim against or involving
Lender without first obtaining Lender's written consent thereto, which consent shall not be unreasonably withheld. 

        (b)    Waiver.    NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS AGREEMENT OR ANYWHERE ELSE, BORROWER
AGREES THAT IT SHALL NOT SEEK FROM LENDER UNDER ANY THEORY OF LIABILITY (INCLUDING ANY THEORY IN TORTS), ANY SPECIAL, INDIRECT, CONSEQUENTIAL OR PUNITIVE DAMAGES. 

        (c)    Survival; Defense.    The obligations in this  Section 10.3 shall survive payment of all other Obligations pursuant to
Section 12.8 of
this Agreement. At the election of any Indemnified Person, Borrower shall defend such Indemnified Person using legal counsel satisfactory to such Indemnified Person in such Person's reasonable
discretion, at the sole cost and expense of Borrower. All amounts owing under this Section 10.3 shall be paid within thirty (30) days
after written demand. 

        11.    Notices.    

        (a)   Unless
otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement or any other agreement entered into in connection herewith
shall be in writing and (except for financial statements and other informational documents which may be sent by first-class mail, postage prepaid) shall be personally delivered or sent by certified
mail, postage prepaid, 

23

 

return
receipt requested, or by prepaid facsimile to Borrower or to Lender, as the case may be, at their respective addresses set forth below: 

	If to Borrower:	 	NuVasive, Inc.

10065 Old Grove Road

San Diego, CA 92131

Attention: Steve McGowan, CFO

Fax: (858) 271-7101

PH: (858) 527-1957
	

If to Lender:	
 	

GATX Ventures, Inc.

3687 Mt. Diablo Blvd., Suite 200

Lafayette, CA 94549

Attention: Contract Administration

Fax: (925) 258-6020

PH: (925) 258-6000
	

 	
 	

With a copy to:
	

 	
 	

GATX Ventures, Inc.

16 Munson Road

Farmington, CT 06032

Attention: Contract Administration

Fax: (860) 284-4350

PH: (860) 284-4300

        The
parties hereto may change the address at which they are to receive notices hereunder, by notice in writing in the foregoing manner given to the other. 

        12.    General Provisions.    

        12.1    Successors and Assigns.    This Agreement shall bind and inure to the benefit of the respective successors and
permitted assigns of each of the parties; provided, however, that neither this Agreement nor any rights hereunder may be assigned by Borrower without Lender's prior written consent, which consent may
be granted or withheld in Lender's sole discretion. Lender shall have the right without the consent of or notice to Borrower to sell, transfer, assign, negotiate, or grant participations in all or any
part of, or any interest in Lender's rights and benefits hereunder. 

        12.2    Time of Essence.    Time is of the essence for the performance of all obligations set forth in this Agreement. 

        12.3    Severabilily of Provisions.    Each provision of this Agreement shall be several from every other provision of
this Agreement for the purpose of determining the legal enforceability of any specific provision. 

        12.4    Entire Agreement; Construction; Amendments and Waivers.    

        (a)   This
Agreement and each of the other Loan Documents dated as of the date hereof, taken together, constitute and contain the entire agreement between Borrower and Lender
and supersede any and all prior agreements, negotiations, correspondence, understandings and communications between the parties, whether written or oral, respecting the subject matter hereof. Borrower
acknowledges that it is not relying on any representation or agreement made by Lender or any employee, attorney or agent thereof, other than the specific agreements set forth in this Agreement and the
Loan Documents. 

24

 

        (b)   This
Agreement is the result of negotiations between and has been reviewed by each of Borrower and Lender executing this Agreement as of the date hereof and their
respective counsel; accordingly, this Agreement shall be deemed to be the product of the parties hereto, and no ambiguity shall be construed in favor of or against Borrower or Lender. Borrower and
Lender agree that they intend the literal words of this Agreement and the other Loan Documents and that no parol evidence shall be necessary or appropriate to establish Borrower's or Lender's actual
intentions. 

        (c)   Any
and all amendments, modifications, discharges or waivers of, or consents to any departures from any provision of this Agreement or of any of the other Loan Documents
shall not be effective without the written consent of Lender. Any waiver or consent with respect to any provision of the Loan Documents shall be effective only in the specific instance and for the
specific purpose for which it was given. No notice to or demand on Borrower in any case shall entitle Borrower to any other or further notice or demand in similar or other circumstances. Any
amendment, modification, waiver or consent effected in accordance with this Section 12.4 shall be binding upon Lender and on Borrower. 

        12.5    Reliance by Lender.    All covenants, agreements, representations and warranties made herein by Borrower shall
be deemed to be material to and to have been relied upon by Lender, notwithstanding any investigation by Lender. 

        12.6    No Set-Offs by Borrower.    All sums payable by Borrower pursuant to this Agreement or any of the
other Loan Documents shall be payable without notice or demand and shall be payable in United States Dollars without set-off or reduction of any manner whatsoever. 

        12.7    Counterparts.    This Agreement may be executed in any number of counterparts and by different parties on
separate counterparts, each of which, when executed and delivered, shall be deemed to be an original, and all of which, when taken together, shall constitute but one and the same Agreement. 

        12.8    Survival.    All covenants, representations and warranties made in this Agreement shall continue in full force
and effect so long as any Obligations and Commitment to fund remain outstanding. The obligations of Borrower to indemnify Lender with respect to the expenses, damages, losses, costs and liabilities
described in Section 10.3 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against
Lender has run. 

        13.    Relationship of Parties.    Borrower and Lender acknowledge, understand and agree that the relationship between
Borrower, on the one hand, and Lender on the other, is, and at all time shall remain solely that of a borrower and lender. Lender shall not under any circumstances be construed to be a partner or
joint venturer of Borrower or any of its Affiliates; nor shall Lender under any circumstances be deemed to be in a relationship of confidence or trust or a fiduciary relationship with Borrower or any
of its Affiliates, or to owe any fiduciary duty to Borrower or any of its Affiliates. Lender does not undertake or assume any responsibility or duty to Borrower or any of its Affiliates to select,
review, inspect, supervise, pass judgment upon or otherwise inform Borrower or any of its Affiliates of any matter in connection with its or their Property, any Collateral held by Lender or the
operations of Borrower or any of its Affiliates. Borrower and each of its Affiliates shall rely entirely on their own judgment with respect to such matters, and any review, inspection, supervision,
exercise of judgment or supply of information undertaken or assumed by Lender in connection with such matters is solely for the protection of Lender and neither Borrower nor any Affiliate is entitled
to rely thereon. 

        14.    Confidentiality.    All information (other than periodic reports filed by Borrower with the Securities and
Exchange Commission) disclosed by Borrower to Lender in writing or through inspection pursuant to this Agreement that is marked confidential shall be considered confidential. Lender agrees to use the
same degree of care to safeguard and prevent disclosure of such confidential information as 

25

 

Lender
uses with its own confidential information, but in any event no less than a reasonable degree of care. Lender shall not disclose such information to any third party (other than to Lender's
partners, attorneys, governmental regulators, or auditors, or to a Lender's subsidiaries and affiliates and prospective transferees and purchasers of the Loans, all subject to the same confidentiality
obligation set forth herein or as required by law, regulation, subpoena or other order to be disclosed) and shall use such information only for purposes of evaluation of its investment in Borrower and
the exercise of Lender's rights and the enforcement of its remedies under this Agreement and the other Loan Documents. The obligations of confidentiality shall not apply to any information that
(a) was known to the public prior to disclosure by Borrower under this Agreement, (b) becomes known to the public through no fault of Lender, (c) is disclosed to Lender by a third
party having a legal right to make such disclosure, or (d) is independently developed by Lender. Notwithstanding the foregoing, Lender's agreement of confidentiality shall not apply to the
extent necessary in connection with any enforcement or exercise of Lender's rights and remedies under this Agreement following an Event of Default, including the enforcement of Lender's security
interest in the Collateral, or to confidential information relating to any Collateral as to which Lender has acquired indefeasible title. 

        15.    CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER.    THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE
WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF BORROWER AND LENDER HEREBY SUBMITS TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL
COURTS LOCATED IN THE NORTHERN DISTRICT OF CALIFORNIA. BORROWER AND LENDER HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF ANY OF THE
LOAN DOCUMENTS OR ANY OF THE TRANSACTIONS CONTEMPLATED THEREIN, INCLUDING CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW OR STATUTORY CLAIMS. 

        IN
WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first above written. 

	 	 	BORROWER:
	

 	
 	

NUVASIVE, INC.
	

 	
 	

By:	
 	

/s/  STEVE MCGOWAN      

	

 	
 	

Title:	
 	

Chief Financial Officer
	

 	

 	

GATX VENTURES, INC.
	

 	
 	

By:	
 	

/s/  PATRICIA W. LEICHER      

	

 	
 	

Title:	
 	

SVP

26

 
 

EXHIBIT A    
    
    Disclosure Schedule    
    

EXHIBIT A  

 DISCLOSURE SCHEDULE  

        Borrower hereby certifies the following information to Lender: 

        Section 1.    Information For UCC Financing Statements and Searches.    

        (a)   The
exact corporate name of the Borrower as it appears in its Certificate of Incorporation, as amended to date is: NuVasive, Inc. 

        (b)   Borrower's
state of incorporation is: Delaware. 

        (c)   The
organizational ID number of the Borrower from its jurisdiction of incorporation is 2775617. 

        (d)   The
Borrower's taxpayer identification number is 33-0768598. 

        (e)   The
following is a list of all Corporate names, dba or trade names used by Borrower in the past five years: NuVasive, Inc. and Nuvasive, Inc. 

        (f)    The
following is a list of all Subsidiaries of Borrower: NuVasive (Europe) GmbH. 

        (g)   The
address of Borrower's headquarters and chief executive office is 10065 Old Grove Road, San Diego, CA 9213 1. The following is a list of all States where Borrower's
headquarters and chief executive office has been located in the past five years: California. 

        (h)   The
following is a list of all States where Borrower's property and assets have been located in the past five years: California and Utah. 

DISCLOSURE SCHEDULE  

        The section numbers in this Disclosure Schedule correspond to the section numbers in that certain Equipment Loan and Security Agreement
(the "Agreement") dated December 27, 2001 by and between NuVasive, Inc., a Delaware Corporation (the "Company"), and GATX Ventures, Inc. ("GATX"); however, any information
disclosed herein under any section number shall be deemed to be disclosed and incorporated into any other section number under the Agreement where such disclosure would otherwise be appropriate. Where
the terms of a contract or other disclosure item have been summarized or described in this Disclosure Schedule, such summary or description does not purport to be a complete statement of the material
terms of such contract or other item. Capitalized terms used herein but not defined herein shall have the meaning assigned to such terms in the Agreement.

        Nothing herein constitutes an admission of any liability or obligation on the part of the Company nor an admission against the Company's interest. The inclusion
of any schedule herein or any exhibit hereto should not be interpreted as indicating that the Company has determined that such an agreement or other matter is necessarily material to the Company. The
GATX acknowledges that certain information contained in these schedules may constitute material confidential information relating to the Company which may not be used for any purpose other than that
contemplated in the Agreement.

Section 1.1

Definitions  

        With respect to subsection (d) of "Permitted Indebtedness," the following Indebtedness exists as of the
date of the Agreement: 

        (a)   Reference
is made to that certain Master Lease Agreement by and between the Company and Comdisco, Inc. dated September 17, 1999, including all schedules
and addenda thereto; and 

        (b)   Reference
is made to that certain Loan and Security Agreement by and between Transamerica Business Credit Corporation and/or its affiliates ("TBCC") and the Company
dated June 27, 2000, and all document referred to therein including the promissory note executed by the Company as of June 27, 2000 in favor of TBCC, the Intellectual Property Security
Agreement 

executed
by the Company in favor of TBCC dated as of June 27, 2000, the Stock Subscription Warrant granted to TBCC dated as of June 27, 2000, and all other documents referenced therein. 

Section 5.1

Organization and Qualification  

        The Company owns a 100% interest in the German entity NuVasive (Europe) GmbH. 

Section 5.7

Litigation  

        Reference is made to the following litigation: 

Medtronic, Inc. and Medtronic Sofamor Danek, Inc. v. NuVasive, Inc., Rufus L. Bennett, Keith Valentine and Patrick Miles, Case No.
CT-001579-01, in the Circuit Court of Shelby County, Tennessee. 

Rufus L. Bennett, Keith Valentine and Patrick Miles v. Medtronic, Inc. and Medtronic Sofamor Danek, Inc., Case No. 01 CV 00684 JM
(JFS), in United States District Court for the Southern District of California. 

Ronald G. Barnett v. James Francis Marino, M.D.;Healthsouth UTC Surgicenter; NuVasive, Inc. and Does I through 100, inclusive, Case
No. GIC 774481, Superior Court of California, County of San Diego. 

Susan L. Klug v. James F. Marino, M.D.; Nick Zelinsky; Jeff Blewett; Curt Stone; Palomar-Pomerado Health System; NuVasive, Inc.; and Does 1 -
50 inclusive, Case No. GIC 777380, Superior Court of California, County of San Diego. 

Kenneth Dixon, Jean Dixon v. James F. Marino, M.D.; Nick Zelensky; Palomar-Pomerado Health System; NuVasive, Inc.; Stryker Corporation and
Does 1 - 50, inclusive, Case No. GIC 777906, Superior Court of California, County of San Diego. 

 
 

EXHIBIT B    
    
    Form of Warrants    
    

        Filed as Exhibits 10.6 and 10.7 to this Registration Statement 

 
 

EXHIBIT C    
    
    Form of Loan Agreement Supplement    
    

EXHIBIT C  

 FORM OF LOAN AGREEMENT SUPPLEMENT  

 LOAN AGREEMENT SUPPLEMENT NO. [    ]  

        LOAN AGREEMENT SUPPLEMENT No. [    ],
dated                        ,            
("Supplement"), to the Equipment Loan and Security Agreement dated as of December 27, 2001 (the "Loan
Agreement") by and among NuVasive, Inc., a Delaware corporation ("Borrower"), and GATX Ventures, Inc. ("Lender"). 

        Unless
otherwise defined herein, capitalized terms have the meanings given to such terms in the Loan Agreement. 

        1.     To
secure the prompt payment by Borrower of the principal of and interest on, and all other amounts from time to time outstanding under the Loan Agreement, and the
performance and observance by Borrower of all the agreements, covenants and provisions contained in the Loan Agreement, Borrower does hereby grant unto Lender, its respective successors and assigns, a
first priority security interest in all of Borrower's right, title and interest in each item of equipment and other property described in Annex A hereto, which equipment and other property
shall be deemed to be additional "Financed Equipment." The list of Financed Equipment in Annex A hereto shall be construed as a supplement to, and deemed part of, the Collateral listed in  Section 4.1 of the Loan Agreement and shall form a part thereof, and the Loan Agreement is hereby incorporated by reference herein and is
hereby ratified, approved and confirmed. 

        2.     The
Financed Equipment shall be located at the following
address:                                        
         .
 

        3.     Attached
as Annex B hereto is the Loan Terms Schedule with respect to the Loan the proceeds of which will be used to finance the Financed Equipment listed in
Annex A hereto. The proceeds for the above referenced Agreement should be disbursed as follows: 

	Disbursement from Lender:	 	 	 
	 	Loan Amount	 	$	 
	 	Less:	 	 	 
	 	 	Interim Payment	 	$	 
	 	 	First payment in Advance	 	$	 
	

Net Proceeds due from Lender:	
 	
$	

 

        4.     The
aggregate net proceeds of the Loan in the amount of $                        shall be transferred to Borrower's account as
follows: 

Account
Name: 

Bank
Name: 

Bank
Address: 

Attention:

Telephone:

Account
Number: 

ABA
Number: 

        5.     Borrower
hereby certifies that (a) the foregoing information is true and correct and authorizes Lender to endorse in its books and records, the Basic Rate
applicable to the Funding Date of the Loan contemplated in this Loan Agreement Supplement and the principal amount set forth in the Loan Terms Schedule; (b) the representations and warranties
made by Borrower in Section 5 of the Loan Agreement and in the other Loan Documents are true and correct on the date hereof and will be true and
correct on such Funding Date; (c) Borrower has met or will by such Funding Date meet all conditions set forth in Section 3 of the Loan
Agreement; (d) Borrower is now, and on such Funding Date will be, in compliance with the covenants and the requirements contained in Sections 4.4, 4.8, 6  

 and 7 of the Loan Agreement; and (e) no Default or Event of Default has occurred under the Loan Agreement. 

        6.     This
Supplement is being delivered in the State of California. 

        7.     This
Supplement may be executed by Borrower and Lender in separate counterparts, each of which when so executed and delivered shall be an original, but all such
counterparts shall together constitute but one and the same instrument. 

[Remainder
of page intentionally left blank.] 

        IN
WITNESS WHEREOF, Borrower and Lender have caused this Supplement to be duly executed and delivered as of this day and year first above written. 

	 	NUVASIVE, INC.
	

 	

By:	

	

 	

Title:	

	

 	

GATX VENTURES, INC.
	

 	

By:	

	

 	

Title:	

Annex A—Description
of Financed Equipment 

Annex B—Loan
Terms Schedule 

ANNEX A 

to 

EXHIBIT
C 

Debtor:
NuVasive, Inc. 

        Secured
Party: GATX Ventures, Inc. 

        The
Collateral shall mean and include all of NuVasive, Inc.'s right, title, interest, claims and demands in and to the listed goods (and embedded computer programs and supporting
information included within the definition of "goods" under the Code), equipment, fixtures or personal property on the pages attached hereto, whether now owned or hereafter acquired, together with all
substitutions, renewals or replacements of and additions, improvements, accessions, replacement parts and accumulations to any and all of such goods, equipment, fixtures or personal property, together
with all proceeds thereof, including, without limitation, insurance, condemnation, requisition or similar payments, and all
proceeds from sales, renewals releases or other dispositions thereof, automatically shall be deemed to be a part of the Collateral listed in the Equipment Loan and Security Agreement (the "Loan
Agreement") and as to which NuVasive, Inc. has granted a security interest to GATX Ventures, Inc., together with a non-exclusive, irrevocable, perpetual, fully paid,
royalty-free license or other right to use, without charge, NuVasive, Inc.'s intellectual property now or hereafter acquired, provided, however, that such license shall only be
exercisable in connection with the disposition of Collateral upon Lender's exercise of its remedies hereunder. Capitalized terms not otherwise defined herein have the meaning given such terms in the
Loan Agreement. 

	 	NUVASIVE, INC.
	

 	

By:	

	

 	

Title:	

FINANCED
EQUIPMENT 

See
Attached Pages. 

 
 

ANNEX B    

        
 LOAN TERMS SCHEDULE 

Loan
Funding Date:                        , 200            

Date
of First Scheduled Payment:            

Maturity
Date:            

Original
Loan Amount: $                  

Basic
Rate:                        % 

Loan
Factor:                        % 

Original
Scheduled Payment Amount *: $                  

Borrower
shall pay to Lender an Interim Payment in the amount of $                        . The Interim Payment is due and payable on the
Funding Date and will be deducted from the disbursement to Borrower. 

*/The
amount of each Scheduled Payment will change if the Loan Amount changes. 

	 	NUVASIVE, INC.
	

 	

By:	

	

 	

Title:	

 
 

EXHIBIT D    
    

[Intentionally
Omitted] 

 
 

EXHIBIT E    
    
    Form of Landlord Agreement    
    

EXHIBIT E  

 LANDLORD AGREEMENT  

RECORDING REQUESTED BY

AND WHEN RECORDED RETURN TO:

GATX Ventures, Inc.

3687 Mt. Diablo Blvd., Suite 200

Lafayette, California 94549 

 
 

CONSENT TO REMOVAL OF PERSONAL PROPERTY    
    

        KNOW ALL PERSONS BY THESE PRESENTS: 

        (a)   The
undersigned has an interest as owner and landlord in the following described real property (the "Real Property"): 

        That
certain real property in the County of [                        ], State of California, described as: 

        SEE ATTACHMENT 1 ATTACHED HERETO FOR FULL LEGAL DESCRIPTION, commonly known as [street address]. 

        (b)   NuVasive, Inc.,
a Delaware corporation ("Borrower"), has entered into or will enter into an Equipment Loan and Security Agreement with GATX Ventures, Inc.
("Lender") dated as of December 27, 2001 (as amended and supplemented from time to time, the "Loan Agreement"). 

        (c)   Lender,
as a condition to entering into the Loan Agreement, require that the undersigned consent to the removal by Lender of the equipment and other assets covered by
the Loan Agreement (hereinafter called "Equipment") from the Real Property, no matter how it is affixed thereto, and to the other matters set forth below. 

        NOW,
THEREFORE, for good and sufficient consideration, receipt of which is hereby acknowledged, the undersigned consents to the placing of the Equipment on the Real Property, and agrees
with Lender as follows: 

        1.     The
undersigned waives and releases each and every right which undersigned now has, under laws of the State of California or by virtue of the lease for the Real Property
now in effect, to levy or distrain upon for rent, in arrears, in advance or both, or to claim or assert title to the Equipment that is already on said Real Property, or may hereafter be delivered or
installed thereon. 

        2.     The
Equipment shall be considered to be personal property and shall not be considered part of the Real Property regardless of whether or by what means it is of may become
attached or affixed to the Real Property. 

        3.     The
undersigned will permit Lender, or its agent or representative, to enter upon the Real Property for the purpose of exercising any right they may have under the terms
of the Loan Agreement or otherwise, including, without limitation, the right to remove the Equipment; provided, however, that if Lender, in removing the Equipment damage any improvements of the
undersigned on the Real Property, Lender will, at its expense, cause same to be repaired. 

        4.     This
agreement shall be binding upon the heirs, successors and assigns of the undersigned and shall inure to the benefit of Lender and its respective successors and
assigns. 

        IN
WITNESS WHEREOF, the undersigned has executed this instrument at                        ,
this                        day
of                        , 2001. 

	

 	
 	

    

	

 	
 	

OWNER/LESSOR
	

 	
 	

By:	
 	

    

	 	 	Title:	 	    

        The
foregoing Consent must be acknowledged before a Notary Public. 

	STATE OF	 	)	 	 	 	 
	 	 	)	 	ss	 	 
	COUNTY OF	 	)	 	 	 	 
	 	 	 	 	 	 	 

        On
the            day
of                        200            before me,
                        Notary Public, personally
appeared            

	    
 or	 	personally known to me
	

    
	
 	

proved to me on the basis of satisfactory evidence

        to
be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that
by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 

        WITNESS
my hand and official seal 

	

 	
 	

    
 SIGNATURE OF NOTARY PUBLIC
	

(S E A L)	
 	

 

 
 

EXHIBIT F    
    
    Form of Service Provider's Consent    
    

EXHIBIT F  

 SERVICE PROVIDER'S WAIVER AND CONSENT  

        THIS SERVICE PROVIDERS WAIVER AND CONSENT (this "Waiver"), dated as
of                        , 200    , is executed by and
between                        ("Service
Provider") and GATX Ventures, Inc., ("Lender") as lender under that certain Equipment Loan and Security Agreement dated as of December 27, 2001 by and between Lender and
NuVasive, Inc. ("Borrower"). 

 RECITALS  

        A.    Service
Provider is the lessee of real property commonly known as [street address] the ("Premises"). Service Provider provides certain services to
Borrower and in connection with such provision of services Service Provider will maintain on the Premises certain equipment (the "Equipment") which is collateral security for certain loans made by
Lender to Borrower. 

        B.    It
is a condition to the making of such loans that Borrower deliver to Lender this Service Provider's Waiver and Consent. 

AGREEMENT  

        NOW, THEREFORE, in consideration of the above recitals and for other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged,
Service Provider and Lender hereby agree as follows: 

        1.    Waiver and Consent.    Service Provider hereby consents to the location of the Equipment on the Premises and
does irrevocably waive, disclaim and relinquish and assign to Lender any and all rights to impose, receive, assert or enforce any lien, encumbrance, charge, security interest, ownership interest,
claim or demand of any kind against or involving the Equipment, whether arising by common law, statute or consensually. Service Provider further agrees that (a) neither the Equipment nor any
item thereof shall become part of, or otherwise be or become a fixture attached to, the Premises, notwithstanding the manner of the Equipment's annexation, the Equipment's adaptability to the uses and
purposes for which the Premises are used, and the intentions of the party making the annexation; (b) the Equipment (or any item thereof) may be repossessed by Lender; and (c) in
connection with such repossession or otherwise, Lender, and any of its agents and employees, may subject to Service Provider's Rules and Regulations that require among other things, that Lender be
accompanied at all times by a representative of Service Provider, enter upon the premises for the purposes of preparing for transport, disassembling, dismantling, loading and/or removing the Equipment
(or any item thereof). 

        2.    Miscellaneous.    This Waiver and all rights hereby granted to Lender hereunder shall remain in effect so long
as there are any obligations owing by Borrower under the Loan Agreement or any present or future agreement between Borrower and Lender which involves the Equipment. All the terms and provisions of
this Waiver shall be binding on and inure to the benefit of the respective successors and assigns of Service Provider and Lender. The rights and benefits of this Waiver may be assigned or transferred
by Lender to third parties who may become a lender, directly or indirectly, to Borrower. This Waiver shall be governed by and construed in accordance with the laws of the State of California. 

        IN
WITNESS WHEREOF, Service Provider and Lender have executed this Waiver as of the date and year first written above. 

	LENDER:	 	SERVICE PROVIDER:
	

GATX Ventures, Inc.	
 	

 	
 	

 
	 	 	 	 	

	

By:	
 	

 	
 	

By:	
 	

 
	 	 	
	 	 	 	

	

Name:	
 	

 	
 	

Name:	
 	

 
	 	 	
	 	 	 	

	

Title:	
 	

 	
 	

Title:	
 	

 
	 	 	
	 	 	 	

 
 

EXHIBIT G    
    
    Form of Officer's Certificate    
    

EXHIBIT G  

 FORM OF OFFICER'S CERTIFICATE  

        GATX
Ventures, Inc. 

        Reference
is made to the Equipment Loan and Security Agreement dated as of December 27, 2001 (as it may be amended from time to time, the "Loan
Agreement") by and between NuVasive, Inc. ("Borrower") and GATX Ventures, Inc.
("Lender"). Unless otherwise defined herein, capitalization terms have the meanings given such terms in the Loan Agreement. 

        The
undersigned Responsible Officer of Borrower hereby certifies to Lender that: 

	1.
	No
Event of Default or Default has occurred under the Loan Agreement. (If a Default or Event of Default has occurred, specify the nature and extent thereof and the action Borrower
proposes to take with respect thereto.)

	2.
	The
information provided in Section 1 of the Disclosure Schedule is currently true and accurate, except as noted below.

	3.
	Borrower
is in compliance with the provisions of Section 4.4, 4.8, 6 and 7 of the Loan Agreement, except as noted below.

	4.
	Attached
herewith are the [monthly financial statements pursuant to Section 6.3(a) of the Loan Agreement/annual audited financial statements pursuant to
Section 6.3(b) of the Loan Agreement]. These have been prepared in accordance with GAAP and are consistent from one period to the next except as noted below. 

NOTES TO ABOVE CERTIFICATIONS:  

	

	

	

 	
 	

NUVASIVE, INC.
	

 	
 	

By:	
 	

    

	 	 	Title:	 	    

LOAN AGREEMENT SUPPLEMENT No. 1 

        LOAN
AGREEMENT SUPPLEMENT No. 1, dated December 31, 2001 ("Supplement"), to the Equipment Loan and Security Agreement dated
as of December 27, 2001 (the "Loan Agreement") by and among NuVasive, Inc., a Delaware corporation
("Borrower"), and GATX Ventures, Inc. ("Lender"). 

        Unless
otherwise defined herein, capitalized terms have the meanings given to such terms in the Loan Agreement. 

        1.     To
secure the prompt payment by Borrower of the principal of and interest on, and all other amounts from time to time outstanding under the Loan Agreement, and the
performance and observance by Borrower of all the agreements, covenants and provisions contained in the Loan Agreement, Borrower does hereby grant unto Lender, its respective successors and assigns, a
first priority security interest in all of Borrower's right, title and interest in each item of equipment and other property described in Annex A hereto, which equipment and other property shall be
deemed to be additional "Financed Equipment." The list of Financed Equipment in Annex A hereto shall be construed as a supplement to, and deemed part of, the Collateral listed in  Section 4.1 of the
Loan Agreement and shall form a part thereof, and the Loan Agreement is hereby incorporated by reference herein and is
hereby ratified, approved and confirmed. 

        2.     The
Financed Equipment shall be located at the addresses as outlined on Schedule No. 1-Annex A attached hereto. 

        3.     Attached
as Annex B hereto is the Loan Terms Schedule with respect to the Loan the proceeds of which will be used to finance the Financed Equipment listed in Annex A
hereto. The proceeds for the above referenced Agreement should be disbursed as follows: 

Disbursement
from Lender: 

	Loan Amount	 	$	585,418.03
	

Less:	
 	
 	

 
	Interim Payment	 	$	641.03
	First payment in Advance	 	$	19,230.87
	Facility Fee	 	$	10,000.00
	 	 	

	Net Proceeds due from Lender:	 	$	555,546.13

        4.     The
aggregate net proceeds of the Loan in the amount of $555,546.13 shall be transferred to Borrower's account as follows: 

	Account Name:	 	NuVasive, Inc.
	Bank Name:	 	Wells Fargo Bank
	Bank Address:	 	 
	Attention:	 	 
	Telephone:	 	 
	Account Number:	 	2018618025
	ABA Number:	 	121000248

        5.     Borrower
hereby certifies that (a) the foregoing information is true and correct and authorizes Lender to endorse in its books and records, the Basic Rate
applicable to the Funding Date of the Loan contemplated in this Loan Agreement Supplement and the principal amount set forth in the Loan Terms Schedule; (b) the representations and warranties
made by Borrower in Section 5 of the Loan Agreement and in the other Loan Documents are true and correct on the date hereof and will be true and
correct on such Funding Date; (c) Borrower has met or will by such Funding Date meet all conditions set forth in Section 3 of the Loan
Agreement; (d) Borrower is now, and on such Funding Date will be, in compliance with the covenants and the requirements contained in Sections 4.4, 4.8, 6  

 and 7 of the Loan Agreement; and (e) no Default or Event of Default has occurred under the Loan Agreement. 

        6.     This
Supplement is being delivered in the State of California. 

        7.     This
Supplement may be executed by Borrower and Lender in separate counterparts, each of which when so executed and delivered shall be an original, but all such
counterparts shall together constitute but one and the same instrument. 

        8.     Borrower
has requested that Lender advance to NuVasive, Inc. on December 31, 2001 a Loan in the amount of $585,418.03 with a Soft Cost allocation of 14% (or
$99,521.07) above the 20% Soft Cost allocation permitted by Section 2.1 of the Loan Agreement (the "Excess Amount"). Lender will agree to the advance with such Excess Amount provided that, not
later than the Commitment Termination Date, Borrower will cause the aggregate original principal amount of all Loans relating to the financing of Other Equipment to equal not more than 20% of the
aggregate original principal amount of all Loans advanced to Borrower under the Loan Agreement. More specifically, if by such date Lender has not advanced additional Loans relating to Eligible
Equipment to Borrower in an amount sufficient to bring the percentage of Loans relating to Other Equipment back to 20%, then Borrower will pay to Lender on such date, in addition to any other amounts
it owes to Lender under the Loan Agreement, an amount equal to the differential between the outstanding principal amount of Loans relating to Other Equipment and 20% of the outstanding principal
amount of all Loans. Borrower's failure to pay such amount in accordance with this letter shall constitute an Event of Default under the Loan Agreement. 

        IN
WITNESS WHEREOF, Borrower and Lender have caused this Supplement to be duly executed and delivered as of this day and year first above written. 

	 	 	BORROWER:
	

 	
 	

NUVASIVE, INC.
	

 	
 	

By:	

/s/ Steve McGowan

	 	 	Title:	Chief Financial Officer

	

 	
 	

GATX VENTURES, INC.
	

 	
 	

By:	

/s/ Patricia W. Leicher

	 	 	Title:	SVP

ANNEX
A—Description of Financed Equipment

ANNEX B—Loan Terms Schedule 

ANNEX B 

LOAN
TERMS SCHEDULE 

Loan
Funding Date: December 31, 2001 

Date
of First Scheduled Payment: January 1, 2002 

Maturity
Date: December 31, 2004 

Original
Loan Amount: $585,418.03 

Basic
Rate: 11.92 % 

Loan
Factor: 3.2850 % 

Original
Scheduled Payment Amount *: $19,230.87 

        Borrower
shall pay to Lender an Interim Payment in the amount of $641.03. The Interim Payment is due and payable on the Funding Date and will be deducted from the disbursement to
Borrower. 

*/The
amount of each Scheduled Payment will change if the Loan Amount changes. 

	 	 	NUVASIVE, INC.
	

 	
 	

By:	

/s/ Steve McGowan

	 	 	Title:	Chief Financial Officer

LOAN TERMS SCHEDULE 

	BORROWER:	 	NuVasive, Inc.	 	MATURITY DATE:	 	12/31/04
	TOTAL COMMITMENT:	 	$1,000,000.00	 	DATE OF FUNDING:	 	12/31/01
	LOAN:	 	$585,418.03	 	SCHEDULE NUMBER:	 	1

ANNEX B TO LOAN AGREEMENT SUPPLEMENT 

	Loan Amount	 	 	 	 	 	$585,418.03
	Basic Rate	 	 	 	 	 	11.920%
	Treasury Rate	 	3.92	%	Spread	 	8.000%
	Loan Factor	 	 	 	 	 	3.2850%
	Scheduled Payment Amount	 	 	 	 	 	$19,230.87

	Interim Payment Amount	 	An additional amount equal to $641.03 for each day from the Funding Date through December 31, 2001 ($641.03 assuming a Funding Date of December 31, 2001) is payable an the Funding Date.
	

Final Payment Amount:	
 	

An additional amount equal to 0% of the original loan amount shall be paid on the maturity date with respect to such loan.

	Payment

Number
	 	Payment

Date
	 	Total

Payment
	 	Prepayment

Value*
	 
	1	 	1/1/02	 	$	19,230.87	 	100.00	%
	2	 	2/1/02	 	$	19,230.87	 	100.00	%
	3	 	3/1/02	 	$	19,230.87	 	99.70	%
	4	 	4/1/02	 	$	19,230.87	 	96.92	%
	5	 	5/1/02	 	$	19,230.87	 	94.12	%
	6	 	6/1/02	 	$	19,230.87	 	91.30	%
	7	 	7/1/02	 	$	19,230.87	 	88.47	%
	8	 	8/1/02	 	$	19,230.87	 	85.63	%
	9	 	9/1/02	 	$	19,230.87	 	82.78	%
	10	 	10/1/02	 	$	19,230.87	 	79.90	%
	11	 	11/1/02	 	$	19,230.87	 	77.02	%
	12	 	12/1/02	 	$	19,230.87	 	74.12	%
	13	 	1/1/03	 	$	19,230.87	 	71.20	%
	14	 	2/1/03	 	$	19,230.87	 	68.28	%
	15	 	3/1/03	 	$	19,230.87	 	65.33	%
	16	 	4/1/03	 	$	19,230.87	 	62.37	%
	17	 	5/1/03	 	$	19,230.87	 	59.40	%
	18	 	6/1/03	 	$	19,230.87	 	56.41	%
	19	 	7/1/03	 	$	19,230.87	 	53.41	%
	20	 	8/1/03	 	$	19,230.87	 	50.39	%
	21	 	9/1/03	 	$	19,230.87	 	47.36	%
	22	 	10/1/03	 	$	19,230.87	 	44.31	%
	23	 	11/1/03	 	$	19,230.87	 	41.25	%
	24	 	12/1/03	 	$	19,230.87	 	38.17	%
	25	 	1/1/04	 	$	19,230.87	 	35.07	%
	26	 	2/1/04	 	$	19,230.87	 	31.96	%
	27	 	3/1/04	 	$	19,230.87	 	28.84	%
	28	 	4/1/04	 	$	19,230.87	 	25.70	%
	29	 	5/1/04	 	$	19,230.87	 	22.54	%
	30	 	6/1/04	 	$	19,230.87	 	19.37	%
	31	 	7/1/04	 	$	19,230.87	 	16.18	%
	32	 	8/1/04	 	$	19,230.87	 	12.98	%
	33	 	9/1/04	 	$	19,230.87	 	9.76	%
	34	 	10/1/04	 	$	19,230.87	 	6.52	%
	35	 	11/1/04	 	$	19,230.87	 	3.27	%
	36	 	12/1/04	 	$	19,230.87	 	0.00	%
	37	 	1/1/05	 	$	—	 	0.00	%

Note 1    The amount of the scheduled payment will change if the loan amount changes. 

*Each prepayment value assumes payment of all scheduled payments due on or before the indicated payment date. 

LOAN AGREEMENT SUPPLEMENT No. 2 

        LOAN
AGREEMENT SUPPLEMENT No.2, dated July 31, 2002 ("Supplement"), to the Equipment Loan and Security Agreement dated as of
December 27, 2001 (the "Loan Agreement") by and among NuVasive, Inc., a Delaware corporation
("Borrower"), and GATX Ventures, Inc. ("Lender"). 

        Unless
otherwise defined herein, capitalized terms have the meanings given to such terms in the Loan Agreement. 

        1.     To
secure the prompt payment by Borrower of the principal of and interest on, and all other amounts from time to time outstanding under the Loan Agreement, and the
performance and observance by Borrower of all the agreements, covenants and provisions contained in the Loan Agreement, Borrower does hereby grant unto Lender, its respective successors and assigns, a
first priority security interest in all of Borrower's right, title and interest in each item of equipment and other property described in Annex A hereto, which equipment and other property shall be
deemed to be additional "Financed Equipment." The list of Financed Equipment in Annex A hereto shall be construed as a supplement to, and deemed part of, the Collateral listed in  Section 4.1 of the
Loan Agreement and shall form a part thereof, and the Loan Agreement is hereby incorporated by reference herein and is
hereby ratified, approved and confirmed. 

        2.     The
Financed Equipment shall be located at 

10065
Old Grove Road, San Diego, CA 92131 

        3.     Attached
as Annex B hereto is the Loan Terms Schedule with respect to the Loan the proceeds of which will be used to finance the Financed Equipment listed in Annex A
hereto. The proceeds for the above referenced Agreement should be disbursed as follows: 

Disbursement
from Lender: 

	Loan Amount	 	$	101,500.00
	

Less:	
 	
 	

 
	Interim Payment	 	$	109.24
	First payment in Advance	 	$	3,277.10
	 	 	

	Net Proceeds due from Lender:	 	$	98,113.66

        4.     The
aggregate net proceeds of the Loan in the amount of $98,113.66, shall be transferred to Borrower's account as follows: 

	Account Name:	 	NuVasive, Inc.
	Bank Name:	 	Wells Fargo Bank
	Bank Address:	 	 
	Attention:	 	 
	Telephone:	 	 
	Account Number:	 	2018618025
	ABA Number:	 	121000248

        5.     Borrower
hereby certifies that (a) the foregoing information is true and correct and authorizes Lender to endorse in its books and records, the Basic Rate
applicable to the Funding Date of the Loan contemplated in this Loan Agreement Supplement and the principal amount set forth in the Loan Terms Schedule; (b) the representations and warranties
made by Borrower in Section 5 of the Loan Agreement and in the other Loan Documents are true and correct on the date hereof and will be true and
correct on such Funding Date; (c) Borrower has met or will by such Funding Date meet all conditions set forth in Section 3 of the Loan
Agreement; (d) Borrower is now, and on such Funding Date will be, in compliance with the covenants and the requirements contained in Sections 4.4, 4.8, 6 and
7 of the Loan Agreement; and (e) no Default or Event of Default has occurred under the Loan Agreement. 

        6.     This
Supplement is being delivered in the State of California. 

        7.     This
Supplement may be executed by Borrower and Lender in separate counterparts, each of which when so executed and delivered shall be an original, but all such
counterparts shall together constitute but one and the same instrument. 

        IN
WITNESS WHEREOF, Borrower and Lender have caused this Supplement to be duly executed and delivered as of this day and year first above written. 

	 	 	NUVASIVE, INC.
	

 	
 	

By:	

/s/ Steve McGowan

	 	 	Title:	CFO

	

 	
 	

GATX VENTURES, INC.
	

 	
 	

By:	

/s/  [ILLEGIBLE]      

	 	 	Title:	President

Annex
A—Description of Financed Equipment

Annex B—Loan Terms Schedules 

EXHIBIT A 

	Debtor:	NuVasive, Inc.
	Secured Party:	GATX Ventures, Inc.

        The
Collateral shall mean and include all of NuVasive, Inc.'s right, title, interest, claims and demands in and to the listed goods (and embedded computer programs and supporting
information included within the definition of "goods" under the Code), equipment, fixtures or personal property on the pages attached hereto, whether now owned or hereafter acquired, together with all
substitutions, renewals or replacements of and additions, improvements, accessions, replacement parts and accumulations to any and all of such goods, equipment, fixtures or personal property, together
with all proceeds thereof, including, without limitation, insurance, condemnation, requisition or similar payments, and all proceeds from sales, renewals, releases or other dispositions thereof,
automatically shall be deemed to
be a part of the Collateral listed in the Equipment Loan and Security Agreement (the "Loan Agreement") and as to which NuVasive, Inc. has granted a security interest to GATX
Ventures, Inc., together with a non-exclusive, irrevocable, perpetual, fully paid, royalty-free license or other right to use, without charge, NuVasive, Inc.'s
intellectual property now or hereafter acquired, provided, however, that such license shall only be exercisable in connection with the disposition of Collateral upon Lender's exercise of its remedies
hereunder. Capitalized terms not otherwise defined herein have the meaning given such terms in the Loan Agreement. 

	

 	
 	

NUVASIVE, INC.
	

 	
 	

By:	
 	

/s/ Steve McGowan

	 	 	Title:	 	CFO

FINANCED
EQUIPMENT

See Attached Pages. 

ANNEX B 

LOAN
TERMS SCHEDULE 

Loan
Funding Date: July 31, 2002 

Date
of First Scheduled Payment: August 1, 2002 

Maturity
Date: July 31, 2005 

Original
Loan Amount: $101,500.00 

Basic
Rate: 10.65% 

Loan
Factor: 3.2287% 

Original
Scheduled Payment Amount*: $3,277.10 

        Borrower
shall pay to Lender an Interim Payment in the amount of $109.24. The Interim Payment is due and payable on the Funding Date and will be deducted from the disbursement to
Borrower. 

*/The
amount of each Scheduled Payment will change if the Loan Amount changes. 

	 	 	NUVASIVE, INC.
	

 	
 	

By:	

/s/ Steve McGowan

	 	 	Title:	CFO

Amortization Schedule  

	Borrower:	 	NuVasive, Inc.	 	MATURITY DATE:	 	07/31/05
	Total Commitment:	 	$1,000,000.00	 	DATE OF FUNDING:	 	07/31/02
	LOAN:	 	$101,500.00	 	SCHEDULE NUMBER:	 	2

Amortization Table at All-in-Rate = 10.65% 

	Date
 
	 	Period
	 	Payment
	 	Principal
	 	Interest
	 	Principal Balance
	 
	08/01/02	 	1	 	3,277.10	 	3,277.10	 	—	 	98,222.90	 
	09/01/02	 	2	 	3,277.10	 	2,405.37	 	871.73	 	95,817.53	 
	10/01/02	 	3	 	3,277.10	 	2,426.72	 	850.38	 	93,390.82	 
	11/01/02	 	4	 	3,277.10	 	2,448.25	 	828.84	 	90,942.56	 
	12/01/02	 	5	 	3,277.10	 	2,469.98	 	807.12	 	88,472.58	 
	01/01/03	 	6	 	3,277.10	 	2,491.90	 	785.19	 	85,980.68	 
	

02/01/03	
 	

7	
 	

3,277.10	
 	

2,514.02	
 	

763.08	
 	

83,466.66	
 
	03/01/03	 	8	 	3,277.10	 	2,536.33	 	740.77	 	80,930.33	 
	04/01/03	 	9	 	3,277.10	 	2,558.84	 	718.26	 	78,371.49	 
	05/01/03	 	10	 	3,277.10	 	2,581.55	 	695.55	 	75,789.94	 
	06/01/03	 	11	 	3,277.10	 	2,604.46	 	672.64	 	73,185.47	 
	07/01/03	 	12	 	3,277.10	 	2,627.58	 	649.52	 	70,557.90	 
	08/01/03	 	13	 	3,277.10	 	2,650.90	 	626.20	 	67,907.00	 
	09/01/03	 	14	 	3,277.10	 	2,674.42	 	602.67	 	65,232.58	 
	10/01/03	 	15	 	3,277.10	 	2,698.16	 	578.94	 	62,534.42	 
	11/01/03	 	16	 	3,277.10	 	2,722.10	 	554.99	 	59,812.32	 
	12/01/03	 	17	 	3,277.10	 	2,746.26	 	530.83	 	57,066.05	 
	01/01/04	 	18	 	3,277.10	 	2,770.64	 	506.46	 	54,295.42	 
	02/01/04	 	19	 	3,277.10	 	2,795.23	 	481.87	 	51,500.19	 
	03/01/04	 	20	 	3,277.10	 	2,820.03	 	457.06	 	48,680.16	 
	04/01/04	 	21	 	3,277.10	 	2,845.06	 	432.04	 	45,835.10	 
	05/01/04	 	22	 	3,277.10	 	2,870.31	 	406.79	 	42,964.79	 
	06/01/04	 	23	 	3,277.10	 	2,895.79	 	381.31	 	40,069.00	 
	07/01/04	 	24	 	3,277.10	 	2,921.49	 	355.61	 	37,147.52	 
	08/01/04	 	25	 	3,277.10	 	2,947.41	 	329.68	 	34,200.10	 
	09/01/04	 	26	 	3,277.10	 	2,973.57	 	303.53	 	31,266.53	 
	10/01/04	 	27	 	3,277.10	 	2,999.96	 	277.14	 	28,226.57	 
	11/01/04	 	28	 	3,277.10	 	3,026.59	 	250.51	 	25,199.98	 
	12/01/04	 	29	 	3,277.10	 	3,053.45	 	223.65	 	22,146.53	 
	01/01/05	 	30	 	3,277.10	 	3,080.55	 	196.55	 	19,065.99	 
	02/01/05	 	31	 	3,277.10	 	3,107.89	 	169.21	 	15,958.10	 
	03/01/05	 	32	 	3,277.10	 	3,135.47	 	141.63	 	12,822.63	 
	04/01/05	 	33	 	3,277.10	 	3,163.30	 	113.80	 	9,659.33	 
	05/01/05	 	34	 	3,277.10	 	3,191.37	 	85.73	 	6,467.96	 
	06/01/05	 	35	 	3,277.10	 	3,219.69	 	57.40	 	3,248.27	 
	07/01/05	 	36	 	3,277.10	 	3,248.27	 	28.83	 	(0.00	)

LOAN TERMS SCHEDULE 

	BORROWER:	 	NuVasive, Inc.	 	MATURITY DATE:	 	7/31/05
	TOTAL COMMITMENT:	 	$1,000,000.00	 	DATE OF FUNDING:	 	07/31/02
	LOAN:	 	$101,500.00	 	SCHEDULE NUMBER:	 	2

ANNEX B TO LOAN AGREEMENT SUPPLEMENT 

	Loan Amount	 	 	 	 	 	$101,500.00
	Basic Rate	 	 	 	 	 	10.650%
	All in Rate	 	 	 	 	 	10.650%
	Treasury Rate	 	2.65	%	Spread	 	8.000%
	Loan Factor	 	 	 	 	 	3.2287%
	Scheduled Payment Amount	 	 	 	 	 	$3,277.10

	Interim Payment Amount	 	An additional amount equal to $109.24 for each day from the Funding Date through July 31, 2002 ($109.24 assuming a Funding Date of July 31, 2002) is payable on the Funding Date.
	

Final Payment Amount:	
 	

An additional amount equal to 0% of the original loan amount shall be paid on the maturity date with respect to such loan.

	Payment

Number
	 	Payment

Date
	 	Total

Payment
	 	Prepayment

Value*
	 
	1	 	8/1/02	 	$	3,277.10	 	100.00	%
	2	 	9/1/02	 	$	3,277.10	 	100.00	%
	3	 	10/1/02	 	$	3,277.10	 	97.99	%
	4	 	11/1/02	 	$	3,277.10	 	95.26	%
	5	 	12/1/02	 	$	3,277.10	 	92.50	%
	6	 	1/1/03	 	$	3,277.10	 	89.74	%
	7	 	2/1/03	 	$	3,277.10	 	86.96	%
	8	 	3/1/03	 	$	3,277.10	 	84.16	%
	9	 	4/1/03	 	$	3,277.10	 	81.36	%
	10	 	5/1/03	 	$	3,277.10	 	78.53	%
	11	 	6/1/03	 	$	3,277.10	 	75.70	%
	12	 	7/1/03	 	$	3,277.10	 	72.85	%
	13	 	8/1/03	 	$	3,277.10	 	69.98	%
	14	 	9/1/03	 	$	3,277.10	 	67.10	%
	15	 	10/1/03	 	$	3,277.10	 	64.21	%
	16	 	11/1/03	 	$	3,277.10	 	61.30	%
	17	 	12/1/03	 	$	3,277.10	 	58.38	%
	18	 	1/1/04	 	$	3,277.10	 	55.45	%
	19	 	2/1/04	 	$	3,277.10	 	52.49	%
	20	 	3/1/04	 	$	3,277.10	 	49.53	%
	21	 	4/1/04	 	$	3,277.10	 	46.55	%
	22	 	5/1/04	 	$	3,277.10	 	43.55	%
	23	 	6/1/04	 	$	3,277.10	 	40.54	%
	24	 	7/1/04	 	$	3,277.10	 	37.51	%
	25	 	8/1/04	 	$	3,277.10	 	34.47	%
	26	 	9/1/04	 	$	3,277.10	 	31.42	%
	27	 	10/1/04	 	$	3,277.10	 	28.34	%
	28	 	11/1/04	 	$	3,277.10	 	25.26	%
	29	 	12/1/04	 	$	3,277.10	 	22.16	%
	30	 	1/1/05	 	$	3,277.10	 	19.04	%
	31	 	2/1/05	 	$	3,277.10	 	15.90	%
	32	 	3/1/05	 	$	3,277.10	 	12.75	%
	33	 	4/1/05	 	$	3,277.10	 	9.59	%
	34	 	5/1/05	 	$	3,277.10	 	6.41	%
	35	 	6/1/05	 	$	3,277.10	 	3.21	%
	36	 	7/1/05	 	$	3,277.10	 	0.00	%
	37	 	8/1/05	 	$	—	 	0.00	%

Note 1    The amount of the scheduled payment will change if the loan amount changes. 

*    Each Prepayment value assumes payment of all scheduled payments due on or before the indicated payment
date. 

QuickLinks

EXHIBIT 10.22

AGREEMENT

EXHIBIT A Disclosure Schedule

EXHIBIT B Form of Warrants

EXHIBIT C Form of Loan Agreement Supplement

ANNEX B

EXHIBIT D

EXHIBIT E Form of Landlord Agreement

CONSENT TO REMOVAL OF PERSONAL PROPERTY

EXHIBIT F Form of Service Provider's Consent

EXHIBIT G Form of Officer's CertificateQuickLinks
 -- Click here to rapidly navigate through this document
  

 
 

EXHIBIT 10.25    
    

 
 

DEVELOPMENT, PRODUCTION    
    
    AND    
    
    MARKETING SERVICES AGREEMENT    
    

        THIS AGREEMENT (the "Agreement") is made and entered into by Tissue Banks International, Inc. ("TBI"), a
Maryland non-profit corporation, and NuVasive Inc. ("NuVasive"), a Delaware corporation as of the 30th day of December, 1999, to be effective as of October 15, 1999 (the
"Effective Date"). 

RECITALS  

        WHEREAS, TBI procures, processes and distributes certain human tissues for transplantation; 

        WHEREAS, NuVasive and TBI desire to develop proprietary tissue processing methods and to process certain allograft materials for use in
minimally invasive spinal surgery procedures; 

        WHEREAS, TBI and NuVasive, in recognition of the need for and benefits that result from the availability of tissues for transplantation,
desire to cooperate with each other in the provision, processing and distribution of such tissue; 

        NOW, THEREFORE, in consideration of the mutual covenants and agreements contained herein, the parties agree as follows: 

        1.    Term.    This Agreement shall become effective as of October 15th, 1999 ("Effective Date") and shall
remain in effect for a period (the "Initial Term") that includes a development period ("Development Period") and a five year commercialization period ("Commercialization Period") (as further defined
in Section 3(b)). Following the expiration of the Initial Term, this Agreement shall be subject to automatic successive renewal terms of one year each, unless either of the parties provides the
other party with written notice, at least three months prior to the expiration of the Initial Term or any successive term, of its intent to modify the terms of, or terminate, this Agreement. 

        2.    Definitions.    Unless otherwise stated in this Agreement: 

        a.     "Donor"
means a Tissue donor; and 

        b.     "Material"
means blocks made from allograft materials pursuant to specifications determined by NuVasive and mutually agreed upon by NuVasive and TBI for the maintenance
of intervertebral space, which can be inserted using NuVasive's proprietary cannulas. 

        c.     References
to TBI in this Agreement shall also include all TBI-owned and affiliated network locations including TBI's primary processing center in San Rafael,
CA. 

        d.     "Tissue"
means human musculoskeletal tissue including bone and connective tissue; 

        3.    Development Period, Commercialization Period.    (a) The Development Period will commence with the
Effective Date. During this period NuVasive will work with TBI personnel to determine a mutually acceptable and commercially and economically viable method of processing and packaging Material,
including planning for and completing the build-out of processing space at TBI in San Rafael, the acquisition of processing tools and machinery, producing test quantities of the Material
and developing and documenting the procedures to be used during the Commercialization Period (the "Development Project"). NuVasive will pay for TBI's Development Project costs as set forth in a
mutually approved budget. The initial budget shall be prepared by the Steering Committee established pursuant to Section 12 hereof on or before March 1, 2000. The initial budget may be
revised, from 

1

 

time
to time, at the request of either party, with the approval of the Steering Committee. Budgeted costs incurred by TBI will be billed to NuVasive as incurred on a monthly basis and will be payable
upon receipt of invoice. All tenant improvements and fixtures installed at TBI's facility in San Rafael shall become the property of TBI upon installation. All equipment, tools, instruments and
machinery ("Equipment") purchased for the Development Project and paid for by NuVasive and used by TBI at TBI's San Rafael facility shall become the property of TBI upon delivery. NuVasive hereby
further grants to TBI the option, at any time, to acquire any such Equipment which is acquired by lease or finance-lease for an amount equal to the amount payable by NuVasive under said lease. TBI
understands that NuVasive has arranged a sale/leaseback facility with Comdisco and will cooperate with NuVasive in providing necessary documentation of expenditures and labeling of assets, if required
by Comdisco, to permit NuVasive to avail itself of this means of financing the Development Project expenditures. NuVasive may abandon the Development Project at any time by giving TBI thirty
(30) days advance written notice, provided that NuVasive has paid all costs incurred for which NuVasive has responsibility pursuant to the most recent budget. 

        (b)   The
Commercialization Period will begin with the processing of the first Material intended for commercial distribution. 

        4.    Recovery.    TBI shall procure Tissue in compliance with the American Association of Tissue Banks ("AATB")
standards and regulations set forth by the United States Food and Drug Administration ("FDA") and/or applicable state or federal laws or regulations. 

        5.    TBI Processing, NuVasive Forecasts.    During the Commercialization Period, TBI will process Tissue into
Material; provided, however, that the specifications for the Material do not conflict with federal or state laws or regulations or AATB standards applicable to human tissue. During the
Commercialization Period, TBI shall use commercially reasonable efforts to maintain at all times a minimum number of Units of Material in stock equal to the amount forecast by NuVasive to be needed by
surgeons in the coming three months, which minimum number may be limited by donor availability, TBI capacity and mutually agreed upon upper limits for Tissue processing by TBI. During the
Commercialization Period, NuVasive shall provide rolling twelve-month forecasts every three months of the amount of Material anticipated to be shipped to customers. TBI shall perform processing on
tissue procured by TBI and shall have the right to secure additional Donor tissue from other AATB accredited tissue banks. TBI processing may include donor screening, physical handling, cutting,
sizing, grinding, sterilization, quality control and packaging. Processing of Tissue for NuVasive shall not prevent TBI's processing of Tissue
for its own distribution. TBI shall, however, utilize the processing facility and Equipment financed by NuVasive and constructed during the Development Period at its San Rafael location on a first
priority basis for the processing of Material sufficient to maintain the minimum supply set forth in forecasts prepared by NuVasive during the Commercialization Period. 

        6.    Distribution.    TBI shall be responsible for the distribution of all Material processed pursuant to this
Agreement directly to customers. All Material processed by TBI during the Commercialization Period shall be maintained in TBI distribution facilities for direct shipment by TBI to customers. 

        7.    Mutual Covenants.    During the Initial Term and any subsequent Term hereof, TBI shall supply Material only for
use in NuVasive's minimally-invasive spinal surgery systems. During the Initial Term and any subsequent Term hereof, TBI shall not supply processed Tissue substantially similar to the Material in
intended use to any third party for use in any minimally invasive surgical system substantially similar to the NuVasive proprietary system. Provided that TBI supplies all of NuVasive's requirements
for Material as forecast pursuant to Section 5 hereof, NuVasive shall not advocate or endorse for use with NuVasive's minimally-invasive spinal surgery systems Material from any other party. In
the event TBI is not permitted to, or elects not to, furnish Material in any state within the United States, NuVasive may arrange to procure necessary supplies of Material from another tissue bank
within such state or states. The foregoing provisions shall not prevent TBI from processing and 

2

 

distributing
its own processed Tissue allografts, including those of the type currently processed by TBI, and any future similar allografts, whether or not similar to the Material, which are not
designed and processed by TBI for use in a minimally invasive surgical system substantially similar to the NuVasive proprietary system. 

        8.    Promotion, Marketing, Billing and Compensation.    

        (a)   The
parties will cooperate in the development of, and have the right to approve, each other's marketing brochures and methods relating to the distribution and marketing
of the Materials, which approval right shall not be unreasonably withheld. Promotion and marketing includes advertising and other medical promotion and the use of medical representatives. 

        (b)   NuVasive
is primarily responsible for the promotion and marketing of the Material, and physician education and training. TBI shall maintain the right to market and
distribute processed Tissue, including Material, directly (co-market) in geographic areas where TBI has in place as of the date of this Agreement a Tissue recovery and distribution program
provided that such marketing and distribution shall not hinder NuVasive's marketing or distribution programs or in any way reduce NuVasive's marketing and distribution fees resulting from medical use
of the Material so distributed. 

        (c)   NuVasive
shall be responsible for customer invoicing, and related accounts receivable and collection functions for Material orders taken or received by NuVasive. TBI
shall be responsible for such functions when it co-markets the Materials. NuVasive shall bill and collect for Materials ordered through NuVasive in TBI's name and shall deposit all funds
collected from such orders directly in a TBI account specified by TBI. TBI shall deliver to NuVasive all amounts due pursuant to subsection (d) below in consideration of NuVasive's services
performed hereunder, and shall retain for itself all remaining funds as compensation for its services provided hereunder. The parties agree to cooperate with each other and to take all actions
necessary or appropriate to carry out their obligations hereunder. 

        (d)   In
consideration of NuVasive's services performed here under, TBI shall pay to NuVasive, solely from the amounts collected from orders for Material: (1) Third
Party Fees (as defined below) that NuVasive is contracted to pay, for which amounts NuVasive shall invoice TBI monthly, and (2)     *** percent (***%) of the revenues
collected by both TBI and NuVasive after first deducting therefrom applicable Third Party Fees. For purposes of this Agreement, Third Party Fees means such fees as NuVasive and/or TBI has contracted
to pay unrelated third parties to provide distribution and promotional services in connection with the Material, which such fees in the aggregate shall not exceed *** percent (***%) of the total
revenues collected by TBI and NuVasive hereunder. Third Party Fees shall not be payable hereunder until the revenues attributable to the Material to which the Third Party Fees relate have been
collected. On or before the fifth day of each month TBI will make such payment to NuVasive from the revenues collected by the Parties during the immediately preceding month. 

	***
	Material
has been omitted pursuant to a request for confidential treatment. 

        9.    Foundation Contribution.    NuVasive shall contribute one dollar ($1) for every Unit of Material distributed by
NuVasive from TBI provided allograft to the Frederick N. Griffith Foundation. The commitment to provide this contribution is made in support of the Foundation's promotion of tissue banking and in
recognition of the unique circumstances related to providing human allograft: a gift of human tissue. Contributions to the Frederick N. Griffith Foundation shall be made quarterly by NuVasive. 

        10.    Compliance with Laws.    It is explicitly understood by both parties that the buying and selling of human
tissue is prohibited by federal and state law and any fees associated with the provision of 

3

 

human
tissue are related to the cost of recovery, processing, distribution and related operating costs of providing human tissue for implantation. 

        11.    Intellectual Property.    

        (a)   (i) All
inventions, original works of authorship, developments, concepts, improvements, designs, discoveries, ideas or trade secrets, whether or not patentable or
registrable under copyright or similar laws conceived, made or discovered by either party, solely or in collaboration with others while working on this commercial effort, during the term of this
Agreement, which relate in any manner to the acquisition or processing of Tissue ("TBI Agreement IP"), are the sole property of TBI. NuVasive agrees to assign (or cause to be assigned) and does hereby
assign fully to TBI all such TBI Agreement IP and any copyrights, patents or other intellectual property rights relating thereto. TBI may, in its sole discretion, obtain patent or other intellectual
property protection for the TBI Agreement IP. 

        (ii)   NuVasive
agrees to assist TBI, or its designee, at TBI's expense, in every proper way to secure TBI's rights in the TBI Agreement IP and any copyrights, patents or
other intellectual property rights relating thereto in any and all countries, including the disclosure to TBI of all pertinent information and data with respect thereto, the execution of all
applications, specifications, oaths, assignments and all other instruments which TBI shall deem necessary in order to apply for and obtain such rights and in order to assign and convey to TBI, its
successors, assigns and nominees the sole and exclusive right, title and interest in and to such TBI Agreement IP, and any copyrights, patents or other intellectual property rights relating thereto.
NuVasive further agrees that, notwithstanding anything to the contrary, NuVasive's obligation to execute or cause to be executed, when it is in NuVasive's power to do so, any such instrument or papers
shall continue after the termination of this Agreement. NuVasive hereby irrevocably designates and appoints TBI and its duly authorized officers and agents as NuVasive's agents and
attorneys-in-fact to act for and on NuVasive's behalf and instead of NuVasive, to execute and file any documents and to do all other lawfully permitted acts to apply for or to
pursue any of TBI's rights in the TBI Agreement IP assigned to TBI above and any copyrights, patents, or other intellectual property rights relating thereto, with the same legal force and effect as if
executed by NuVasive. 

        (iii)  TBI
shall grant NuVasive a non-exclusive royalty-free, non-transferable, non-sublicensable, worldwide license to use
the TBI Agreement IP in the course of its business of designing, using or otherwise applying the Materials. NuVasive agrees that if NuVasive incorporates into any TBI Agreement IP any invention,
improvement, development, concept, discovery or other proprietary information owned by NuVasive or in which NuVasive has an interest related to the specific processing of the Materials, TBI is hereby
granted and shall have a non-exclusive, royalty-free, perpetual, irrevocable, worldwide license to make, have made, modify, use and sell such item as party of or in connection
with such TBI Agreement IP. 

        (b)   (i) Except
for TBI Agreement IP, all inventions, original works of authorship, developments, concepts, improvements, designs, discoveries, ideas or trade secrets,
whether or not patentable or registrable under copyright or similar laws conceived, made or discovered by either party, solely or in collaboration with others while working on this commercial effort,
during the term of this Agreement, which relate in any manner to the subject matter hereof ("NuVasive Agreement IP"), are the sole property of NuVasive. TBI agrees to assign (or cause to be assigned)
and does hereby assign fully to
NuVasive all such NuVasive Agreement IP and any copyrights, patents or other intellectual property rights relating thereto. NuVasive may, in its sole discretion, obtain patent or other intellectual
property protection for the NuVasive Agreement IP. 

        (ii)   TBI
agrees to assist NuVasive, or its designee, at NuVasive's expense, in every proper way to secure NuVasive's rights in the NuVasive Agreement IP and any copyrights,
patents or other intellectual property rights relating thereto in any and all countries, including the disclosure to 

4

 

NuVasive
of all pertinent information and data with respect thereto, the execution of all applications, specifications, oaths, assignments and all other instruments which NuVasive shall deem necessary
in order to apply for and obtain such rights and in order to assign and convey to NuVasive, its successors, assigns and nominees the sole and exclusive right, title and interest in and to such
NuVasive Agreement IP, and any copyrights, patents or other intellectual property rights relating thereto. TBI further agrees that, notwithstanding anything to the contrary, TBI's obligation to
execute or cause to be executed, when it is in TBI's power to do so, any such instrument or papers shall continue after the termination of this Agreement. TBI hereby irrevocably designates and
appoints NuVasive and its duly authorized officers and agents as TBI's agents and attorneys-in-fact to act for and on TBI's behalf and instead of TBI, to execute and file any
documents and to do all other lawfully permitted acts to apply for or to pursue any of NuVasive's rights in the NuVasive Agreement IP assigned to NuVasive above and any copyrights, patents, or other
intellectual property rights relating thereto, with the same legal force and effect as if executed by TBI. 

        (iii)  NuVasive
shall grant TBI a non exclusive royalty-free, non-transferable, non-sublicensable, worldwide license to use the NuVasive
Agreement IP in the course of its business in the distribution, processing or packaging of other materials not similar in purpose to the Materials. TBI agrees that if TBI incorporates into any
NuVasive Agreement IP any invention, improvement, development, concept, discovery or other proprietary information owned by TBI or in which TBI has an interest related to the specific processing of
the Materials, NuVasive is hereby granted and shall have a non-exclusive, royalty-free, perpetual, irrevocable, worldwide license to make, have made, modify, use and sell such
item as party of or in connection with such NuVasive Agreement IP. 

        12.    Quality Assurance.    

        (a)   TBI
and NuVasive shall agree upon, implement and maintain a quality control program relating to the processing, storage and distribution of the Materials. 

        (b)   Each
party shall permit the other access to their respective facilities and staff for the purpose of quality assurance. Any such inspections shall: (i) be
performed upon reasonable notice during normal business hours; (ii) identify the staff that will perform such inspection; (iii) maintain as confidential any
information or observation made as part of such inspection; (iv) conduct themselves in an appropriate manner; (v) not unnecessarily interfere with operations; and (v) as
applicable, provide a written report to the other party of the inspection. 

        (c)   NuVasive
shall provide TBI with copies of applicable procedures and specifications. NuVasive will provide training as appropriate. TBI shall provide Materials to
NuVasive that meet NuVasive's specifications, subject to Section 4, above. Each of NuVasive and TBI shall provide copies of applicable documentation to the other party as it relates to
Materials provided to NuVasive from TBI including donor information, donor testing results, tissue production records, tissue release records, audit reports, FDA inspection reports, AATB inspection
reports and shipping records. 

        (d)   As
appropriate, each party will inform the other of complaints and suspected adverse reactions or outcomes in a timely manner and agree to coordinate the evaluation of
such events. 

        (e)   NuVasive
and TBI will be responsible for Materials and applicable Tissue tracing and TBI will provide NuVasive with a copy of all returned tracing cards for any Donor. 

        13.    Steering Committee, Emergency Meetings.    There will be appointed a steering committee comprised of Two
representatives from each party that will meet regularly to discuss matters of mutual concern. Pricing of the Materials will be reviewed at least annually by such steering committee prior to the
parties' budget cycles. Either party to this Agreement may call an emergency meeting of the parties 

5

 

at
any time. Such meetings may be called to discuss changes in pricing and the allocation of proceeds between the parties pursuant to Exhibit A as a result of unanticipated and significant
changes in any of the parties' costs relating to the Materials or market price pressures and competitive issues. 

        14.    Insurance and Indemnification.    Both parties understand and acknowledge that TBI shall not maintain any
insurance for the benefit of NuVasive and NuVasive shall not maintain any insurance for the benefit of TBI; accordingly, each party must maintain its own insurance for all risks related to each
party's activities. 

        (a)   Each
party hereto ("Indemnitor") agrees to defend, indemnify, and hold harmless, the other party (the "Indemnitee") and its officers, directors, and employees, from any
claims, demands or legal proceedings (including without limitation the costs, expenses, and reasonable attorney's fees incurred in connection with the defense of any such matter) which may be made or
brought against the Indemnitee by any third party by reason of or arising out of the Indemnitor's breach of the duties and obligations required by this Agreement to be performed by it or the
Indemnitor's gross negligence, or willful misconduct. 

        (b)   Commencing
not later than the first date of implantation of Material into a living human, each party shall maintain a separate policy or policies of insurance in amounts
customary in the industry for businesses engaged in similar activities for insuring against liability which may be imposed arising out of its acts or omissions to include: i) comprehensive
general liability providing coverage for personal injury, bodily injury, property damage and product liability; and ii) professional liability. 

        15.    Governing Law.    This Agreement shall be governed by and construed in a accordance with the laws in the State
of California. 

        16.    Public Disclosure.    Neither TBI nor NuVasive shall make any public release of information regarding the
matters contemplated herein except, that joint press releases in agreed form may be issued by TBI and NuVasive and that TBI and NuVasive may each continue such communications with employees,
customers, suppliers, lenders, lessors and other particular groups as may be legally required, necessary or appropriate and not inconsistent with the best interests of the other party without
disclosing the details of the Agreement, and as required by law. 

        17.    Termination.    Either party may terminate the Agreement upon material breach of the Agreement by the other
party upon ninety (90) days prior written notice, unless the breaching party has cured the applicable breach within such period. 

        18.    Entire Agreement.    This Agreement and attachments contain the entire understanding of the parties with
respect to the matters contained herein. In case one or more amendments, modifications or alterations of this Agreement become necessary, the parties shall negotiate in good faith on such amendments,
modifications or alterations. This Agreement may be amended, modified or altered only by an instrument in writing duly executed by both parties. 

        19.    Force Majeure.    The parties hereto shall not be liable in any manner for the failure or delay in fulfillment
of all or part of this Agreement, directly or indirectly, owing to governmental orders or restrictions, war, war-like conditions, revolution, riot, looting, strike, lockout, fire, flood or
other external causes or circumstances beyond the parties' control. 

        20.    Confidentiality.    Each party agrees to treat any confidential and proprietary information concerning the
other party which is received from the other party in connection with the Development Project and the commercial distribution of the Material, provided that the information is either:
(a) disclosed in writing and clearly marked confidential, or (b) disclosed orally and promptly after disclosure confirmed in writing to be confidential ("Confidential Information").
Confidential Information does not include information which: (i) is or becomes generally available to the public 

6

 

other
than as a result of a breach of this nondisclosure agreement by the receiving party or its agents; (ii) was within the receiving party's possession prior to its being furnished by or on
behalf of the disclosing party; (iii) is or becomes available to the receiving party on a confidential basis from a source other than the disclosing party or its agents; (iv) is
disclosed by the disclosing party to a third party without a duty of confidentiality; (v) is independently developed by the receiving party without use of Confidential Information of the
disclosing party; or (vi) is disclosed by the receiving party or its agents with the discloser's prior written approval. Each party agrees that it and its agents will use the other party's
Confidential Information solely for the purpose of performing its obligations hereunder, and that the disclosing party's Confidential Information will be kept confidential and not disclosed to any
person other than agents of the receiving party who require the Confidential Information to assist the receiving party in performing its obligations hereunder. Notwithstanding the foregoing, a party
may disclose any Confidential Information of the other party to the extent required by law or legal proceedings, provided that the party releasing the Confidential Information shall use all reasonable
efforts to provide advance notice to the other party of the required disclosure. 

        22.    Assignability.    Neither party to this Agreement may assign any rights or obligations under this Agreement to
any other entity or person without the advance written consent of the other party. 

        23.    Severability.    If any one or more of the provisions of this Agreement shall for any reason be held to be
illegal or unenforceable, such invalidity or unenforceability shall not affect any other provisions of this Agreement or the validity or enforceability of such provision. The unenforceable provision
shall be treated as severable and the remaining provisions shall nevertheless continue in full force and effect, giving maximum effect to the intent of the parties in entering this Agreement. 

        24.    Notices.    Any notice or report required or permitted to be given or made under this Agreement by one of the
parties hereto to the other shall be in writing and shall be deemed to have been sufficiently given for all purposes, and effective as of the date of mailing, if mailed by registered or certified
mail, postage prepaid, addressed to such other party as its respective address as follows: 

	 	 	If to TBI:	 	Tissue Bank International

815 Park Avenue

Baltimore, Maryland 21201

Attention: Gerald J. Cole	 	 
	

 	
 	

If to NuVasive	
 	

NuVasive, Inc.

10065 Old Grove Road, Suite A

San Diego, California 92131

Attention: Alex Lukianav	
 	

 

        25.    Attorneys' Fees.    The prevailing party in any legal dispute arising hereunder shall be entitled to payment of
its reasonable attorneys' fees and court costs by the other party. 

	TISSUE BANKS INTERNATIONAL	 	NUVASIVE, INC.
	

By:	
 	

/s/ GERALD J. COLE 12/30/99
 Gerald J. Cole, Executive Vice President	
 	

By:	
 	

/s/ ALEX LUKIANAV 1/10/00
 Alex Lukianov, President and CEO
	

Attest:	
 	

/s/ illegible, Pres/CEO

1/03/00	
 	

Attest:	
 	

/s/ illegible, Exec. Assist.

1/10/00

7

 
 

FIRST AMENDMENT TO
  DEVELOPMENT, PRODUCTION
  AND
  MARKETING SERVICES AGREEMENT    
    

        This First Amendment to development, Production and Marketing Services Agreement (the "First Amendment") is entered into effective October 1st, 2001, by
and between Tissue Banks International, Inc. ("TBI"), a Maryland non-profit corporation, and NuVasive, Inc. ("NuVasive"), a Delaware corporation, and amends that certain
Development, Production and Marketing Services Agreement entered into between the parties dated December 30, 1999 (the "Agreement"). 

        Now,
THEREFORE, in consideration of the mutual covenants and agreements contained herein, the parties agree as follows: 

	1.
	Sub-Section 8(d)
of the Agreement is hereby modified and restated in full as follows:

	i.
	Because
the final delivery of Materials in many cases is made by NuVasive in combination with related instrumentation and corresponding to these deliveries, NuVasive will
bill customers directly. TBI shall, on a weekly basis, invoice NuVasive for the associated processing fees for Materials which TBI has transferred to TBI's finished inventory ready for distribution to
end users (finished inventory). 

The
amount that TBI bills to NuVasive for the transfers of Material to finished inventory is based on amounts that NuVasive will bill to final end users of the Material. For Material which is
delivered, and Marketed by NuVasive or its representative the value of revenues that are billed the end users shall be apportioned with***% being ultimately retained by NuVasive as
reimbursement for their services performed and ***% to TBI as its processing fee. The ***% to TBI will be paid within 30 days from receipt of invoices that TBI provides NuVasive for the
transfer of Material to TBI's finished inventory. 

	***
	Material
has been omitted pursuant to a request for confidential treatment. 

For
materials delivered or transferred to finished inventory prior to August 31, 2001, payment will be made to TBI within 10 days of receipt of invoice except that NuVasive may deduct
from such transfers its prior payments to YOH Scientific for personnel used by TBI, with such payments to YOH Scientific substantiated by copies of invoices. 

NuVasive
may direct the movement of Materials from TBI's finished inventory to customers or its facilities or other locations, as it deems appropriate. TBI will use best efforts to ship Materials
quickly. Shipping will be paid by NuVasive 

	(ii)
	For
Material co-marketed by TBI that is ordered by third parties directly from TBI, distributed by TBI or its agents and used in surgery without the
assistance of NuVasive personnel, TBI will pay NuVasive ***% of the revenue billed for Material an a weekly basis—30 days subsequent to shipment and billing to said customer.
Material co-marketed by TBI as described here in section 1 (ii) will not be considered as transferred to finished inventory as per 1(i) above.

	2.
	This
First Amendment shall control and govern any provisions of the Agreement that are inconsistent with this First Amendment. All other terms and conditions of the Agreement remain in
full force and effect.

	3.
	This
First Amendment is subject review and possible modification effective January 1, 2002. 

        IN
WITNESS WHEREOF, the parties have executed this First Amendment affective the date set forth above. 

	TISSUE BANKS INTERNATIONAL	 	NUVASIVE, INC.
	

By:	
 	

/s/ GERALD J. COLE 9/25/01
 President/CEO	
 	

By:	
 	

/s/ ALEX LUKIANAV

QuickLinks

EXHIBIT 10.25

DEVELOPMENT, PRODUCTION AND MARKETING SERVICES AGREEMENT

FIRST AMENDMENT TO DEVELOPMENT, PRODUCTION AND MARKETING SERVICES AGREEMENT

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