Document:

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                                                                   Exhibit 10.35

                                                November 22, 2005

Mr. Robert Cobuzzi
[address]

Dear Bob:

       Congratulations on your retirement. The purpose of this letter (the
"Letter") is to confirm the terms regarding your continued employment with and
retirement from Akamai Technologies, Inc. ("Akamai" or the "Company"). As more
fully set forth below, Akamai desires to provide you with certain retirement
benefits in exchange for certain agreements by you.

       1.     CONTINUATION OF EMPLOYMENT AND RETIREMENT.

       (i)    You will remain employed on a full-time basis as Akamai's Chief
Financial Officer, and your duties and compensation (including any bonus for
which you may be eligible) will remain unchanged, through December 31, 2005. You
will retain the title of Chief Financial Officer until such time as the Company
completes its full year financial reporting and filing requirements for 2005
(which we anticipate will be completed on or about March 10, 2006); however, as
of January 1, 2006, your principle duties will be to complete the Company's
full-year financial reporting and filing requirements for 2005, including but
not limited to, assisting on a part- to full-time basis, as needed, to finalize
and file Akamai's Form 10-K for 2005.

       (ii)   After such time as the Company completes its full year financial
reporting and filing requirements for 2005 you will become a Special Advisor to
the Chief Financial Officer, and you agree that you will be available as a
consultant to provide advice and counsel regarding financial matters on an
as-needed basis, as determined and requested by the CFO. You acknowledge that
your employment with Akamai will terminate effective December 31, 2006 (the
"Separation Date").

       (iii)  Notwithstanding the foregoing, Akamai reserves the right to
terminate your employment immediately and without notice, and with it any
Retirement Benefits (as defined below) to which you are otherwise entitled, at
any time before the Separation Date for any of the following reasons: (1) your
willful and repeated failure to perform your assigned duties or to comply in any
material respect with the reasonable written policies, standards or regulations
of the Company; (2) your committing an act of fraud, dishonesty, embezzlement
that is materially injurious to the Company, or your conviction of a felony; or
(3) your material breach of this Letter or the NDA (as defined below).

       2.     RETIREMENT BENEFITS. In exchange for the mutual covenants set
forth in this Letter, and subject to the conditions set forth herein, including,
but not limited to, the conditions set forth in Sections 3 and 5, Akamai agrees
to provide you with the following retirement benefits (the "Retirement
Benefits"):

       You will remain on Akamai's payroll and receive your current base salary
       ($210,000 on an annualized basis) through the Separation Date. These
       payments, less all applicable

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November 22, 2005
Page 2

       federal, state, local and other employment-related taxes and deductions,
       will be made on a bi-weekly basis in accordance with Akamai's usual
       payroll practices. In addition, while you remain on Akamai's payroll,
       your stock options will continue to vest in accordance with the terms of
       the written stock option agreements between you and Akamai, and you will
       remain eligible for all Akamai medical, dental and disability insurance
       benefits.

       You acknowledge and agree that the Retirement Benefits provided in this
Letter are not otherwise due or owing to you under any Akamai employment
agreement (oral or written) or Akamai policy or practice, and that the
Retirement Benefits to be provided to you are not intended to, and shall not
constitute, a severance plan, and shall confer no benefit on anyone other than
the parties hereto. You further acknowledge that except for (i) the specific
financial consideration set forth in this Letter, (ii) payment of accrued and
unused vacation time earned through the Separation Date, (iii) payment of
bonuses, if any, earned for fiscal year 2005, and (iv) expense reimbursement for
previously submitted expenses in accordance with Akamai's expense reimbursement
policies, you are not and shall not in the future be entitled to any other
compensation including, without limitation, other wages, commissions, bonuses,
vacation pay, holiday pay, or any other form of compensation or benefit.

       3.     CONFIDENTIALITY/NON-SOLICITATION/OTHER OBLIGATIONS BY YOU. You
       expressly acknowledge and agree to the following:

       (i)    no later than December 31, 2006, you will have returned to Akamai
all Akamai documents (and any copies thereof) and property; you shall abide by
the provisions of the Non-Competition, Non-Solicitation, Proprietary and
Confidential Information and Developments Agreement that you signed when you
began your employment at Akamai (the "NDA," the terms of which shall survive the
signing of this Letter);

       (ii)   for one (1) year immediately following the Separation Date, you
shall not, directly or indirectly, solicit, induce or attempt to influence any
employee of Akamai to terminate his or her employment with Akamai;

       (iii)  a breach of this Section 3 shall constitute a material breach of
this Letter and, in addition to any other legal or equitable remedy available to
Akamai, shall entitle Akamai to recover any monies paid to you under Section 2
of this Letter. You also acknowledge that the provisions of this Section 3 are
reasonable and necessary to protect Akamai's business interests, and further
that your breach of the covenants set forth in this Section 3 would constitute a
material breach of the Letter, that Akamai would suffer substantial irreparable
harm and that Akamai would not have an adequate remedy at law for such breach.
Therefore, in recognition of these acknowledgements, you agree that in the event
of a breach of any of these covenants, in addition to such other remedies as
Akamai may have at law, Akamai, without posting any bond, shall be entitled to
obtain, and you agree not to oppose, and to waive all defenses to, a request for
equitable relief in the form of specific performance or temporary, preliminary
or permanent injunctive relief, or any other equitable remedy which then may be
available. The seeking of such injunction or order shall not affect Akamai's
right to seek and obtain damages or other equitable relief on account of any
such actual or threatened breach. You further acknowledge and agree to
enforcement of these covenants under the laws of and in the Commonwealth of
Massachusetts, where Akamai maintains its worldwide headquarters, where all
personnel and benefit plans are administered, documents

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November 22, 2005
Page 3

maintained, where this Letter has been executed by you and Akamai, and where
witnesses and documents relating to any dispute would be primarily located.

       4.     FUTURE COOPERATION. You agree that you shall cooperate fully with
Akamai in connection with any matter or event relating to your employment or
events that occurred during your employment, including, without limitation, in
the defense or prosecution of any existing claims or actions, and any claims or
actions not in existence or which may be brought or threatened in the future
against or on behalf of Akamai, including any claims or actions against its
officers, directors and employees. Your cooperation in connection with such
matters, actions and claims shall include, without limitation, being available,
upon reasonable notice, to meet with Akamai regarding matters in which you have
been involved, and any contract matters or audits; to prepare for any proceeding
(including, without limitation, depositions, consultation, discovery or trial);
to provide affidavits; to assist with any audit, inspection, proceeding or other
inquiry; and to act as a witness in connection with any litigation or other
legal proceeding affecting Akamai. You shall be reimbursed for actual and
reasonable out-of-pocket expenses incurred in providing such cooperation under
this Section. You further agree that should you be contacted (directly or
indirectly) by any person or entity (for example, by any party representing an
individual or entity) adverse to Akamai, you shall promptly notify the General
Counsel at Akamai.

       5.     RELEASE OF CLAIMS. You hereby agree and acknowledge that by
signing this letter and accepting the Retirement Benefits to be provided to you,
and other good and valuable consideration provided for in this Letter, you are
waiving your right to assert any form of legal claim against Akamai whatsoever
for any alleged action, inaction or circumstance existing or arising from the
beginning of time through the effective date of this Letter. Your waiver and
release herein is intended to bar any form of legal claim, charge, complaint or
any other form of action (jointly referred to as "Claims") against Akamai
seeking any form of relief including, without limitation, equitable relief
(whether declaratory, injunctive or otherwise), the recovery of any damages or
any other form of monetary recovery whatsoever (including, without limitation,
back pay, front pay, compensatory damages, emotional distress damages, punitive
damages, attorneys fees and any other costs) against Akamai, for any alleged
action, inaction or circumstance existing or arising through the effective date
of this Letter.

       Without limiting the foregoing general waiver and release, you
specifically waive and release Akamai from any Claim arising from or related to
your employment relationship with Akamai or the termination thereof, including,
without limitation:

      ** Claims under any state or federal discrimination, fair employment
         practices or other employment related statute, regulation or executive
         order (as they may have been amended through the Separation Date)
         prohibiting discrimination or harassment based upon any protected
         status including, without limitation, race, national origin, age,
         gender, marital status, disability, veteran status or sexual
         orientation. Without limitation, specifically included in this
         paragraph are any Claims arising under the federal Civil Rights Acts of
         1866 and 1871, Title VII of the Civil Rights Act of 1964, the Civil
         Rights Act of 1991, the Equal Pay Act, the Americans With Disabilities
         Act, the Age Discrimination in Employment Act, the Older Workers
         Benefits Protection Act, and any similar state statute.

      ** Claims under any other state or federal employment related statute,
         regulation or executive order (as they may have been amended through
         the Separation Date) relating to wages, hours or any other terms and
         conditions of employment. Without limitation, specifically included in
         this

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November 22, 2005
Page 4

         paragraph are any Claims arising under the Fair Labor Standards Act,
         the Family and Medical Leave Act of 1993, the National Labor Relations
         Act, the Employee Retirement Income Security Act of 1974, the
         Consolidated Omnibus Budget Reconciliation Act of 1985 (COBRA) and any
         similar state statute, including any applicable payment of wages
         statutes.

      ** Claims under any state or federal common law theory including, without
         limitation, wrongful discharge, breach of express or implied contract,
         promissory estoppel, unjust enrichment, breach of a covenant of good
         faith and fair dealing, violation of public policy, defamation,
         interference with contractual relations, intentional or negligent
         infliction of emotional distress, invasion of privacy,
         misrepresentation, deceit, fraud or negligence.

      ** Any other Claim arising under state or federal law.

       Notwithstanding the foregoing, this section does not release Akamai from
any obligation expressly set forth in this Letter. You acknowledge and agree
that, but for providing this waiver and release, you would not be receiving the
Retirement Benefits being provided to you under the terms of this Letter. You
further agree that on the Separation Date, you will sign and deliver to the
Company a General Release and Waiver of All Claims, in the form attached hereto,
by which you waive and release any and all claims arising between the effective
date of this Letter and the Separation Date.

       BECAUSE YOU ARE OVER FORTY (40) YEARS OF AGE, YOU HAVE SPECIFIC RIGHTS
UNDER THE OLDER WORKERS BENEFITS PROTECTION ACT, WHICH PROHIBITS DISCRIMINATION
ON THE BASIS OF AGE, AND YOU ARE ADVISED THAT THE RELEASES SET FORTH IN THIS
SECTION ARE INTENDED TO RELEASE ANY RIGHT THAT YOU MAY HAVE TO FILE A CLAIM
AGAINST AKAMAI ALLEGING DISCRIMINATION ON THE BASIS OF AGE.

       It is Akamai's desire and intent to make certain that you fully
understand the provisions and effects of this Letter. To that end, you have been
encouraged and given the opportunity to consult with legal counsel for the
purpose of reviewing the terms of this Letter. Akamai is providing you with
twenty-one (21) days (until December 14, 2005) in which to consider and accept
the terms of this Letter by signing below and returning it to me at Akamai
Technologies, Inc., 8 Cambridge Center, Cambridge, MA 02142.

       6.     ENTIRE AGREEMENT/SUCCESSORS/CHOICE OF LAW/ENFORCEABILITY. You
acknowledge and agree that, with the exception of the NDA, this Letter
supersedes any and all prior or contemporaneous oral and/or written agreements
between you and Akamai, and sets forth the entire agreement between you and
Akamai with respect to the subject matter herein. No variations or modifications
hereof shall be deemed valid unless reduced to writing and signed by the parties
hereto. This Letter will be binding upon and inure to the benefit of the parties
and their respective heirs, successors and assigns. This Letter shall be deemed
to have been made in the Commonwealth of Massachusetts, shall take effect as an
instrument under seal within Massachusetts, and shall be governed by and
construed in accordance with the laws of the Commonwealth of Massachusetts,
without giving effect to conflict of law principles. You agree that any action,
demand, claim or counterclaim relating to the terms and provisions of this
Letter, or to its breach, shall be commenced in Massachusetts in a court of
competent jurisdiction, and you further acknowledge that venue for such actions
shall lie exclusively in Massachusetts and that material witnesses and documents
would be located in Massachusetts. The provisions of this letter are severable,
and if for any reason any part hereof shall be found to be unenforceable, the
remaining provisions shall be enforced

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November 22, 2005
Page 5

in full. Both parties further agree that any action, demand, claim or
counterclaim shall be resolved by a judge alone, and both parties hereby waive
and forever renounce the right to a trial before a civil jury.

       By executing this Letter, you are acknowledging that you have been
afforded sufficient time to understand the terms and effects of this letter,
that your agreements and obligations hereunder are made voluntarily, knowingly
and without duress, and that neither Akamai nor its agents or representatives
have made any representations inconsistent with the provisions of this letter.

       If the foregoing correctly sets forth our understanding, please sign,
date and return both signed copies of this letter to me at Akamai within
twenty-one (21) days. One signed copy will be returned to you.

                                        Very truly yours,

                                        Akamai Technologies, Inc.

                                        By: /s/ Paul Sagan
                                            ------------------------------------
                                            Paul Sagan, President and CEO

                                        Dated: November 22, 2005

Confirmed, Agreed and Acknowledged:

/s/ Robert Cobuzzi
------------------------------
Robert Cobuzzi

Dated: December 6, 2005

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November 22, 2005
Page 6

                    GENERAL RELEASE AND WAIVER OF ALL CLAIMS

       Robert Cobuzzi, for good and valuable consideration, the sufficiency of
which is hereby acknowledged, for her/himself and for her/his heirs, executors,
administrators, estates, agents, servants, representatives, attorneys, insurers
and assigns (collectively, the "Releasor"), hereby to the extent permitted by
law, voluntarily, irrevocably and unconditionally releases and forever discharge
Akamai Technologies, Inc. (the "Company"), its affiliated entities, its and
their predecessor and successor organizations and assigns, and each of its and
their present, former and future shareholders, directors, officers, employees,
agents, servants, representatives, attorneys and insurers (collectively, the
"Releasees"), from all actions, causes of action, suits, debts, sums of money,
accounts, covenants, contracts, agreements, promises, damages, judgments,
demands and claims whatsoever, whether known or unknown, suspected or
unsuspected, in law or in equity, whether statutory or common law, whether
federal, state, local or otherwise, which the Releasor now has, owns, or holds,
or claims to have, own or hold, or which at any time heretofore, had owned or
held, or claimed to have owned or held, or which the Releasor at any time
hereafter may have, own, or hold, or claim to have, own or hold against each, or
any or all of the Releasees, based upon, arising out of or in connection with
any circumstances, matter or state of fact from the beginning of the world to
the date of this General Release and Waiver of All Claims, including but not
limited to claims arising out of or in any way related to Releasor's hiring or
employment at the Company, or his resignation of, termination or retirement from
that employment, or any related matters, including but not limited to claims
arising under the Civil Rights Act of 1866, Title VII of the Civil Rights Act of
1964, the Civil Rights Act of 1991, the Americans with Disabilities Act of 1990,
the Age Discrimination in Employment Act, the Older Workers Benefits Protection
Act, the Family and Medical Leave Act of 1993, the Immigration Reform and
Control Act of 1986, Fair Labor Standards Act, the National Labor Relations Act,
the Employee Retirement Income Security Act of 1974, the Consolidated Omnibus
Budget Reconciliation Act of 1985 (COBRA), and any and all similar Massachusetts
or other state statutes, including any applicable payment of wages statutes, and
all other claims, including but not limited to claims under any state or federal
common law theory.

       THIS MEANS RELEASOR MAY NOT SUE THE COMPANY FOR ANY CURRENT OR PRIOR
       CLAIMS ARISING OUT OF HIS EMPLOYMENT WITH, RESIGNATION, TERMINATION OR
       RETIREMENT FROM THE COMPANY, INCLUDING ANY CLAIMS ALLEGING DISCRIMINATION
       ON THE BASIS OF AGE.

       Releasor represents that he understands the various claims he could have
asserted under the laws set forth above; that he has read this Release carefully
and understands all its provisions; that he understands that he has the right to
and is advised to consult an attorney concerning this Release and in particular
any waiver of rights he might have made under these laws; that the consideration
received by Releasor is above and beyond the payments or benefits otherwise owed
to him under the terms of his employment with the Company or required by law;
that to the extent, if any, that he desired, he availed himself of this right.

       Releasor may rescind this Release if, within seven (7) days after he
signs this Release, he delivers a notice of rescission to the General Counsel at
Akamai. To be effective, such rescission must be hand delivered or postmarked
within the seven (7) day period and sent by certified mail, return receipt
requested, to General Counsel, Akamai Technologies, Inc., 8 Cambridge Center,
Cambridge, MA 02142.

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November 22, 2005
Page 7

       IN WITNESS WHEREOF, Releasor has knowingly and voluntarily signed and
sealed this Release on this ____ day of _____________, 2006.

                                            ------------------------------------
                                            Robert Cobuzzi<PAGE>
                                                                   EXHIBIT 10.39

                AMENDMENT NO. 1 TO ADDENDUM RE: INFLUENZA PROGRAM

                                       TO

                  RESEARCH COLLABORATION AND LICENSE AGREEMENT

      This AMENDMENT NO. 1 TO ADDENDUM RE: INFLUENZA PROGRAM TO RESEARCH
COLLABORATION AND LICENSE AGREEMENT (this "Amendment"), effective as of March
14, 2006, by and between Novartis Institutes for BioMedical Research, Inc., a
corporation organized and existing under the laws of Delaware, with its
principal place of business at 250 Massachusetts Avenue, Cambridge,
Massachusetts 02139 ("Novartis"), and Alnylam Pharmaceuticals, Inc., a
corporation organized and existing under the laws of Delaware, with its
principal place of business at 300 Third Street, 3rd Floor, Cambridge,
Massachusetts 02142 ("Alnylam"), amends that certain Addendum Re: Influenza
Program to Research Collaboration and License Agreement, dated February 17,
2006, by and between Novartis and Alnylam (the "Addendum"). For the purposes of
this Amendment, capitalized terms, whether used in the singular or plural form,
shall have the respective meanings ascribed to such terms in the Addendum,
unless defined herein.

      WHEREAS, prior to the date hereof, Novartis and Alnylam entered into the
Addendum; and

      WHEREAS, Novartis and Alnylam desire to amend the Addendum pursuant to the
terms of this Amendment.

      NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged by the parties, the parties agree
as follows:

      1. The phrase "effective as of December 13, 2005" contained in the first
sentence of the Addendum hereby is deleted in its entirety and the phrase
"effective as of February 17, 2006" is inserted in lieu thereof.

      2. The Addendum, as amended by this Amendment, together with the other
writings referred to in the Addendum or delivered pursuant thereto which form a
part thereof, contain the entire agreement among the parties with respect to the
subject matter thereof and amend, restate and supersede all prior and
contemporaneous arrangements or understandings with respect thereto.

      3. Upon the effectiveness of this Amendment, on and after the date hereof,
each reference in the Addendum to "this Addendum," "hereunder," "hereof,"
"herein" or words of like import, and each reference in the other documents
entered into in connection with the Addendum, shall mean and be a reference to
the Addendum, as amended hereby. Except as specifically amended above, the
Addendum shall remain in full force and effect and is hereby ratified and
confirmed.

<PAGE>

      4. This Amendment may be executed in any number of counterparts, and each
such counterpart shall be deemed to be an original instrument, but all such
counterparts together shall constitute but one agreement.

                  [Remainder of Page Intentionally Left Blank]

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      IN WITNESS WHEREOF, Alnylam and Novartis have caused this Amendment No. 1
to Addendum Re: Influenza Program to Research Collaboration and License
Agreement to be duly executed by their authorized representatives, as of the
date first written above.

                                        ALNYLAM PHARMACEUTICALS, INC.

                                        By: /s/ John M. Maraganore
                                        Name: John M. Maraganore
                                        Title: President and CEO

                                        NOVARTIS INSTITUTES FOR
                                        BIOMEDICAL RESEARCH, INC.

                                        By: /s/ Jeremy Levin
                                        Name: Jeremy Levin
                                        Title: Vice President and
                                        Global Head Strategic Alliances

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