Document:

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                                                                   EXHIBIT 10.21

                                ROYALTY AGREEMENT

             THIS ROYALTY AGREEMENT made this 15th day of October, 1998 by and
       between Genomic Solutions, Inc., a Delaware corporation ("GSI") with a
       principal place of business at 4355 Varsity Drive, Ann Arbor, Michigan
       48108, and Millipore Corporation, a Massachusetts corporation
       ("Millipore") with a principal place of business at 80 Ashby Road,
       Bedford, MA 01730.

             WHEREAS, simultaneously with the execution of this Agreement, GSI
       is purchasing the assets of the Electrophoresis Business (the "Business")
       of ESA, Inc. (the "Seller") including, without limitation, all rights of
       the licensee under that certain license agreement, dated September 15,
       1987, as amended (the "PDI License Agreement"), between Millipore and
       Protein Databases Inc.;

             WHEREAS, the Seller entered into a Royalty Agreement, dated July
       31, 1996, with Millipore (the "'96 Royalty Agreement"), pursuant to which
       Seller agreed to pay Millipore royalties on the sale of Products (as
       defined below);

              WHEREAS, GSI has required as a condition to such purchase, that
        the Seller obtain the consent of Millipore; and

             WHEREAS, Millipore wishes to obtain the royalty described herein
       and has required as a condition to giving its consent to such sale that
       GSI enter into this Royalty Agreement with Millipore;

               NOW, THEREFORE, in consideration of the premises and the mutual
        agreements hereinafter set forth, GSI and Millipore agree as follows:

                 1. GSI shall pay to Millipore a royalty in an amount equal to
        two percent (2%) of Net Sales Revenues (as hereinafter defined) received
        by GSI up to a maximum aggregate amount of royalties paid to
        Millipore hereunder of $950,000.

             2. As used herein, the following terms shall have the following
       meaning:

                 (a) "Net Sales Revenues" shall mean amounts paid to GSI or its
             Affiliates for the sale of Products less (i) freight, shipping and
             handling; (ii) packaging; (iii) sales, use or other taxes or
             charges and import or export duties; (iv) cash or other trade
             discounts or allowances, including volume discounts; and (v)
             amounts paid or credited with respect to returns or allowances,
             whether related to defective or non-conforming goods or otherwise;
             (vi) commissions to third parties which are not Affiliates of GSI;
             and (vii) intercompany sales between GSI and its Affiliates. In no
             event shall Net Sales Revenue include any amount attributable to
             any part of any equipment, product or system, which part is not a
             Product.

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                    (b) "Products" shall mean all products that: (1) were
               designed or manufactured by the Seller's predecessor, Oxford
               GlykoSystems, Inc., in its conduct of its Electrophoresis
               Business; (ii) were designed or manufactured by the Seller using
               any of the technology transferred by Millipore to the said Oxford
               GlykoSystems, Inc. in February, 1995 (the "Millipore
               Technology"); or (iii) are hereafter designed or manufactured by
               GSI using the Millipore Technology.

                    (c) "Affiliate" shall mean, with respect to any Person, any
               other Person which directly or indirectly controls, is controlled
               by, or is under common control with, such Person. A Person
               shall be regarded as in control of another Person only if it
               owns, or directly or indirectly controls, at least fifty percent
               (50%) of the voting stock or other ownership interest of the
               other Person.

                    (d) "Person" shall mean any individual, corporation,
               partnership or other entity.

          3. Royalty payments due to Millipore shall accrue to Millipore in the
     calendar quarter in which GSI receives payment of relevant Net Sales
     Revenues and shall be payable to Millipore within forty-five (45) days
     after the end of such quarter. At the time of making each royalty payment,
     GSI shall provide Millipore a written report describing sales in the
     quarter and the method of calculation of the royalties.

          4. GSI shall keep accurate records of the Products sold by it which
     generate Net Sales Revenues. Upon written request by Millipore received by
     GSI at least three business days prior to the proposed date of inspection
     and made not more than once per calendar year, GSI shall make such records
     available for inspection by Millipore at GSI's principal place of business
     during normal business hours and on a confidential basis. As a condition to
     any such inspection, Millipore and each of its representatives
     participating in the inspection shall execute and deliver to GSI prior to
     such inspection a nondisclosure agreement in a form which GSI shall
     reasonably request. Neither Millipore nor any of its representatives shall
     disclose any information acquired as a result of any such inspection to any
     person or entity or use any such information other than in connection with
     a review of royalties paid by GSI hereunder or enforcement of Millipore's
     rights hereunder.

          5. Millipore represents and warrants to GSI as follows:

          (a) Millipore will not release any rights to practice the intellectual
     property licensed to Millipore under the PDI License Agreement without
     GSI's prior written consent.

          (b) Following transfer of the assets of the Business to GSI, GSI will
     not have any obligation to PDI with respect to such assets, the Products or
     the PDI License Agreement, and GSI's sole obligation and liability to
     Millipore in

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          connection with the use or sale of such assets (including, without
          limitation, the use of  intellectual property licensed to Millipore
          under the PDI License Agreement) or the sale of Products shall be the
          payment of the royalties required hereunder, provided that GSI shall
          provide Millipore with the written report of sales and calculation of
          royalties required by paragraph 3 for the quarter in which this
          Agreement is signed covering all sales in such quarter by GSI
          beginning with sales on the date hereof.

          6. All obligations with respect to the payment of all royalties due to
     PDI under the PDI License Agreement have expired. Millipore agrees to
     indemnify and hold GSI harmless with respect to all claims by PDI for
     royalties due under the PDI License Agreement.

          7. This Royalty Agreement shall be governed by, and construed and
     enforced in accordance with, the substantive laws of The Commonwealth of
     Massachusetts.

          IN WITNESS WHEREOF, GSI and Millipore have executed this Agreement as
     of the date first above written.

                                             GENOMIC SOLUTIONS, INC.

                                             By: /s/ Jeffrey S. Williams
                                                ------------------------------
                                             Name:   Jeffrey S. Williams
                                             Title:  President and CEO

                                             MILLIPORE CORPORATION

                                             By: /S/ Francis J. Lungen
                                                ------------------------------
                                             Name:   Francis J. Lungen
                                             Title:  VP & CEO

                                       3<PAGE>   1
                                                                   EXHIBIT 10.22

                            ASSET PURCHASE AGREEMENT

         THIS ASSET PURCHASE AGREEMENT (the "Agreement") is made and entered
into as of June 27, 1997, by and among B.I. SYSTEMS CORPORATION, d/b/a BIO
IMAGE ("Purchaser"), a Delaware corporation, BIOPHOTONICS CORPORATION
("Seller"), a Michigan corporation and JEFF STIEGMAN, the President and the sole
shareholder of Seller ("Stiegman").

                                    RECITALS:

         A. Among other businesses, Seller is engaged in the business of
designing, developing, manufacturing, marketing and selling equipment used in
electrophoresis, a technique for separating proteins and DNA. With respect to
this Agreement, Seller's business shall be limited to that part of the business
that relates to electrophoresis (the "Business").

         B. Seller desires to sell, and Purchaser desires to purchase, all of
the operating assets of Seller used or usable in connection with the operation
of the Business, including but not limited to, the Business as a going concern,
and the goodwill and other intangible assets associated with the Business, for
the consideration and upon the terms and conditions set forth below.

         NOW, THEREFORE, for and in consideration of the foregoing Recitals, the
mutual covenants and agreements contained herein and other good and valuable
consideration, the receipt and adequacy of which is hereby mutually
acknowledged, the parties agree as follows:

                                    ARTICLE I

             PURCHASE AND SALE OF ASSETS; ASSUMPTION OF LIABILITIES

         1.1 PURCHASE AND SALE OF ASSETS. Subject to all of the terms and
conditions contained in this Agreement, and except as provided below, on the
Closing Date (defined below), Seller shall sell, transfer, assign and deliver to
Purchaser, and Purchaser shall purchase from Seller, all assets and properties
of every kind and nature, real and personal, tangible and intangible, wherever
situated, owned by Seller or in which Seller has any right or interest that are
used or usable in connection with the Business (all such assets and properties
being referred to in this Agreement as the "Assets"), including, without
limitation, the following:

                  (a) Inventories. All inventories of whatever nature or kind
         relating to the Business ("Inventories"), except that the Inventories
         shall not include any obsolete or surplus inventory as defined in
         Section 3.9 below;

                  (b) Equipment and Other Personal Property. All equipment,
         machinery, furniture and fixtures, office machines, maintenance and
         office supplies, signs, leasehold improvements, and all other tangible
         property used or usable in connection with the Business ("Personal
         Property"), including, without limitation, the assets listed on the
         attached Exhibit 1.1(b);

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                  (c) Business Records. All data bases, sales and business
         records, inventory records, product specifications, correspondence,
         maintenance, operating and production records, personnel records of
         Seller's employees, credit records (or copies thereof) of customers and
         vendors of Seller's Business, customer and vendor lists, marketing or
         other studies relating to Seller's Business cost and pricing
         information, and originals or copies of all books, records and other
         documents which relate to the Business or the Assets ("Records");

                  (d) Licenses. To the extent permitted under applicable law or
         regulation, all governmental licenses and permits used or usable in
         connection with the Business ("Licenses");

                  (e) Intangibles. All right, title and interest, if any, which
         Seller has in any intangible property, rights or claims relating to the
         Business or to the Assets to be transferred, including, without
         limitation, all deposits, goodwill to the extent the same exists,
         patents and pending applications for patents, copyrights and
         applications for copyrights, trademarks, service marks, logos or other
         commercial symbols, trade names and the like, and interests thereunder,
         telephone numbers, prepaid expenses, credits, claims for refund and
         other prepaid items, and all other property and rights used or usable
         in connection with the Business, of whatever kind or nature, whether or
         not specifically referred to in this Agreement ("Intangibles");

                  (f) Leases and Agreements. Those agreements, leases and
         contracts to which Seller is a party or to which the Assets are subject
         and which are listed on the attached Exhibit 1.1(f) (the "Assumed
         Business Contracts"). Exhibit 1.1(f) shall be updated as of the Closing
         Date; and

                  (g) Warranty Rights. All third party warranties relating to
         the Business or the acquired assets, whether express or implied, and
         claims arising under warranties, representations and guaranties made to
         Seller in connection with the Business.

                  (h) Accounts Receivable. All accounts receivable of Seller,
         but only to the extent they are for products shipped subsequent to June
         13, 1997, and also the University of Maryland account receivable for
         Invoice Number 430938.

         1.2 EXCLUDED ASSETS. Notwithstanding anything to the contrary contained
in Section 1.1 above, the following assets (collectively, the "Excluded
Assets"), are not being sold by Seller to Purchaser:

                  (a) Assets Not Related to the Business. Any and all assets not
         owned by Seller, or in which Seller does not have an interest, or which
         are not used or usable in the Business;

                  (b) Cash on Hand. All cash on hand;

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                  (c) Securities. All securities of whatever nature or kind;

                  (d) Accounts Receivable. All customer accounts and notes
         receivable relating to the Business, other than those described in
         Section 1.1(h) above.

                  (e) Corporate Records. The minute books, stock books,
         corporate seal and other corporate records of Seller relating to its
         organization and existence, provided that such records shall be made
         available to Purchaser upon request after execution of this Agreement
         for inspection and copying at all times during normal business hours;

                  (f) Excluded Contracts. Any and all contracts, leases or
         agreements other than the Assumed Contracts (the "Excluded Business
         Contracts");

                  (g) Employee Benefit Plans. The Employee Benefit Plans, as
         defined in Section 3.14;

                  (h) BioPhotonics Corporation Name. All right, title and
         interest, if any, which Seller has in the name "BioPhotonics
         Corporation", and all variations of that name; and

                  (i) Tax Returns. All tax returns of Seller and all tax refunds
         due Seller from any governmental agency.

         1.3 ASSUMPTION OF LIABILITIES. Purchaser shall not assume or purchase
the Assets subject to, and shall not be liable for, any liabilities of Seller,
of whatever nature, type or kind whatsoever, whether matured or contingent,
except for (i) the obligations of Seller arising from and after the Closing Date
with respect to the Assumed Business Contracts, (ii) Seller's trade payables
attributable to inventory received by Seller in the normal course of the
Business after June 13, 1997, (iii) the obligations of Seller pursuant to
invoice number 115 from BioSupply, Inc., in the amount of $6,170.00, and (iv)
the obligations of Seller pursuant to order number 3756 from Eaton Publishing,
in the amount of $3,995.00. The assumption by Purchaser of any of Seller's
liabilities shall in no way expand the rights or remedies of any third party
against Purchaser or Seller as compared to the rights and remedies which such
third party would have had against Seller had Purchaser not assumed the
liabilities.

                                   ARTICLE II

                     PURCHASE PRICE, PAYMENT AND ALLOCATION

         2.1 CONSIDERATION. For and in consideration of the Assets, Purchaser
shall pay to Seller the sum of Three Hundred Fifty-Two Thousand Three Hundred
($352,300.00) Dollars (the "Cash Purchase Price") and shall issue shares of its
common stock to Seller, as provided below.

         2.2 PAYMENT. The Cash Purchase Price shall be paid as follows:

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                  (a) At the Closing (defined below) Purchaser shall pay to
         Seller the sum of Ninety-Seven Thousand Three Hundred ($97,300.00)
         Dollars, (the "Closing Payment") by cashier's check or wire transfer of
         immediately available funds;

                  (b) On the Closing Date, Purchaser shall deposit Fifty
         Thousand ($50,000.00) Dollars into an escrow account to be held
         pursuant to an escrow agreement substantially in the form attached
         hereto as Document 2.2(b) (the "Escrow Agreement");

                  (c) Purchaser shall pay Seller the sum of Fifty Thousand
         ($50,000.00) Dollars following the completion of Stiegman's twelfth
         (12th) month as an employee of Purchaser, as provided in Section 2.5;
         and

                  (d) On the Closing Date, Purchaser shall deposit One Hundred
         Fifty-Five Thousand Dollars ($155,000.00) into an escrow account to be
         held pursuant to an escrow agreement (the "Comerica Escrow Agreement")
         between Seller, Comerica Bank and an escrow agent, a copy of which
         Comerica Escrow Agreement shall be given to Purchaser at the Closing;

         2.3 ISSUANCE OF SHARES. As additional consideration for the Assets, at
the Closing, Purchaser shall issue to Seller Eighty-Five Thousand (85,000)
shares (the "Shares") of Purchaser's common stock, $.001 par value (the "Common
Stock"). The parties have agreed that the value of the Shares is $.07 per Share.

         2.4 OPTIONS. At the Closing, Purchaser shall grant Stiegman an option
to purchase Fifty Thousand (50,000) shares of the Common Stock, at an exercise
price of $0.07 per share, in accordance with the terms and conditions of a Stock
Option Agreement, the form of which is attached as Document 2.4 (the "Option
Agreement").

         2.5 EMPLOYMENT OF STIEGMAN. At the Closing, Stiegman and Purchaser will
enter into an Employment Agreement, the form of which is attached as Document
2.5.

         2.6 PURCHASE PRICE ALLOCATION. The Cash Purchase Price and the value of
the Shares shall be allocated among the Assets in accordance with the attached
Exhibit 2.6.

                                   ARTICLE III

                    REPRESENTATIONS, WARRANTIES AND COVENANTS

         Seller and Shareholder understand that each of the following
representations and warranties are material and have been relied on by
Purchaser. Seller and Shareholder each represent, warrant and covenant to
Purchaser that the statements contained in this Article III are correct and
complete as of the date of this Agreement and will be correct and complete as of
the Closing Date (as though made on the Closing Date), except as set forth in
the disclosure schedule attached to this Agreement and initialed by Seller and
Purchaser (the "Disclosure Schedule"). The Disclosure Schedule shall

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be prepared by Seller and arranged in sections corresponding to the lettered and
numbered sections contained in this Article III.

         3.1 ORGANIZATION. Seller is duly organized, validly existing and in
good standing under the laws of the State of Michigan. Seller has full corporate
power and authority, and all franchises, licenses and permits as are necessary
to own, lease and operate its respective properties and assets and to carry on
its businesses as presently conducted. The Disclosure Schedule sets forth each
jurisdiction in which the Seller is licensed or qualified to do business as a
foreign corporation. Seller is duly qualified to do business as a foreign
corporation in all jurisdictions where the nature of its business makes such
qualification necessary and where the absence of such qualification would not
have the material adverse effect on the operations or financial condition of the
Business (a "Material Adverse Effect"). Seller has no wholly or partially owned
subsidiaries, and the Seller does not own or control, in whole or in part, any
other corporation, association, partnership or other business entity.

         3.2 POWER AND AUTHORITY. Seller has, and on the Closing Date will have,
all requisite power and authority to enter into, carry out and perform its
obligations under this Agreement and all other instruments and agreements
contemplated in this Agreement. The execution of this Agreement and the
consummation of the transactions contemplated herein have been duly authorized
and approved by Seller's Board of Directors and shareholders. This Agreement
constitutes, and all agreements and instruments contemplated hereby when
executed and delivered in accordance with the terms of this Agreement will
constitute, valid and binding obligations of Seller, enforceable in accordance
with their respective terms, except to the extent limited by bankruptcy,
insolvency, and other laws of general application relating to or affecting the
enforcement of creditors' rights and general equity principles.

         3.3 ABSENCE OF VIOLATIONS. Neither the execution, delivery, performance
or compliance with this Agreement and all other agreements contemplated hereby,
nor the consummation of the transactions herein contemplated, will (i) violate,
conflict with, or constitute a default or breach of Seller's Articles of
Incorporation, or bylaws or other constituent documents, (ii) constitute a
violation by Seller of any law, rule, regulation, ordinance, order, writ,
injunction, decree or judgment applicable to Seller or affecting the Assets or
Business, (iii) result, or with the passage of time will result, in any breach
or violation of, or be in conflict with or constitute a default, or give to
others any rights of termination or cancellation of, or accelerate the
performance required by or maturity of, any document or instrument binding on or
affecting Seller, the Assets or the Business, subject to obtaining the consents
to the other parties to the Assumed Business Contracts to the extent required
therein or as required by law or (iv) result in the creation of any lien, charge
or encumbrance on any of the Assets.

         3.4 FINANCIAL STATEMENTS. Seller has delivered to Purchaser Seller's
compiled balance sheets and the related statements of operations, retained
earnings and cash flows for each of the fiscal years ended December 31, 1995
through December 31, 1996 (the "Annual Financial Statements"), and the interim
financial statements for the quarter ended March 31, 1997, and the months ended
April 30, 1997 and May 31, 1997 (the "Interim Statements", and together with the
Annual Financial Statements, the "Statements"). The Annual Financial Statements
are true,

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correct and complete in all material respects, present fairly and accurately the
financial position of Seller as at such dates and the results of its operations
and earnings for the periods indicated thereon, and have been prepared
substantially in accordance with generally accepted accounting principles
consistently applied throughout the periods indicated. The Interim Statements
have been prepared on a cash basis substantially in accordance with management's
accounting policies consistently applied through the periods indicated. The
Statements make full and adequate provisions for all obligations, liabilities or
commitments, whether fixed or contingent as of the respective periods described
in them.

         3.5 NO UNDISCLOSED LIABILITIES OR CHANGES. Except as and to the extent
reflected on the Statements, and except for current liabilities incurred by
Seller in the ordinary course of business since May 31, 1997, Seller has no
material debts, liabilities or obligations of any nature or kind, whether
absolute, accrued, contingent or otherwise, and whether due or to become due,
including without limitation, any debts, liabilities (and tax liabilities due or
to become due) or obligations relating to or arising out of any act,
transaction, circumstance or state of facts which occurred or existed on or
before the date of this Agreement. Seller is not aware of any existing, proposed
or threatened change which would be a material adverse change to Seller, the
Business or their future prospects. Since May 31, 1997, there has not occurred
any material adverse change in the assets, liabilities, business, financial
condition, operations, results of operations or future prospects of Seller or
the Business, and from such date through the Closing Date, Seller has and will
maintain the Assets in a prudent manner in the ordinary course of business, and
will carry on the Business in the ordinary course, consistent with past
practices. Without limiting the generality of the foregoing, since such date,
Seller has not, except as set forth in the Disclosure Statement: (i) permitted
or suffered any material adverse change in its assets, other than sales of
inventory, if any, in the ordinary and normal course of business consistent with
past practices; (ii) suffered any material change, destruction or loss adversely
affecting the Assets; (iii) suffered any event or condition of any character,
which materially and adversely affects the Business or Assets; (iv) entered into
any employment, bonus, deferred compensation, incentive compensation, service
award, pension, retirement or other benefit arrangement, other than employment
arrangements entered into in the ordinary course of business and terminable "at
will" by the Seller or the employee; (v) entered into any, or amended or
terminated any existing, material contract, agreement, franchise, permit or
license; (vi) incurred any material debts or obligations or mortgaged, pledged
or subjected to lien any of its Assets or properties, or entered into any
commitment to borrow money or guaranteed any debts or obligations of any person
or entity, which will encumber the Assets after conveyance to the Purchaser or
will otherwise be binding on the Purchaser; (vii) sold or transferred any of its
Assets or properties, except in the ordinary course of business, or canceled,
compromised or waived any debts, claims or rights of material nature; (viii)
suffered any strike, unauthorized work stoppage, organizing attempts,
grievances, or any like activities, affecting any of its employees; (ix)
discharged or satisfied any lien or encumbrance, or paid any obligation or
liability, except current liabilities becoming due in the ordinary course of
business; (x) terminated or modified any material agreement, right or license
benefiting Seller or the Business; (xi) revalued its assets; (xii) instituted,
settled or agreed to settle any litigation, action or proceeding before any
court or governmental body materially affecting the Business or the Assets;
(xiii) failed to replenish its inventories, if any, and supplies in a normal and
customary manner or made any purchase commitment in excess of normal,

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ordinary and usual requirements, or made any material change in its selling,
pricing, advertising or personnel practices; (xiv) made any change in accounting
principles or methods, or in the manner of keeping books, accounts and records
of Seller; (xv) entered into any transaction other than in the ordinary course
of business, other than this Agreement; (xvi) entered into any agreement or made
any payment of any nature, directly or indirectly, to any shareholder, director,
officer, employee or affiliate of Seller, except distributions of cash to
shareholders or as compensation for services performed in amounts consistent
with past practices or goods purchased in the ordinary course of business;
(xvii) made any distributions of any nature whatsoever directly or indirectly to
any person or firm who is a shareholder or owner of Seller other than
distributions of cash to shareholders; or (xviii) entered into any agreement or
made any commitment to do any of the things described in clauses (i) through
(xvii) above. Further, without the prior written approval of Purchaser, from the
date hereof through the Closing Date, Seller shall not, whether by act or
omission, voluntarily or involuntarily, cause or allow any of the events or
things described in clauses (i) through (xviii) above to occur.

         3.6 TAX MATTERS. Seller has duly filed all tax returns and reports
required to be filed by it, including, where applicable, all federal, foreign,
state, county and local income, gross receipts, excise, import, property,
franchise, ad valorem, license, sales, use, and withholding tax reports and
returns. Seller has filed all reports required by law or regulation to be filed
and has duly paid, or accrued on its books of account and will pay when due, all
duties and charges due or assessed against it, the Business or the Assets. There
are not now, nor on the Closing Date will there be, any assessments, charges,
paybacks or obligations requiring payment of any nature or description against
any of the Assets which remain unpaid, except for current taxes not yet due or
payable and except for the liabilities to be assumed by Purchaser pursuant to
Section 1.3.

         3.7 TANGIBLE PROPERTY. Seller has good and marketable title to each
item comprising the Assets, free and clear of all title defects and objections,
security interests, liens, charges and encumbrances of any nature whatsoever
("Liens"). Seller owns and will convey to Purchaser all fixtures, machinery,
equipment and other tangible assets necessary for the conduct of its Business as
presently conducted, and Exhibit 1.1(b) attached hereto contains a true and
complete list of all such tangible Personal Property used in the operation of
the Business as presently conducted.

         3.8 INTELLECTUAL PROPERTY. The Disclosure Schedule sets forth a
complete and accurate list of all patents, patent registrations, patent
applications, trade names, service names, trademarks, publication titles,
service marks, and the registration or applications for any of the foregoing,
trade secrets, inventions, processes, customer lists, copyrights, copyright
rights and registrations or applications, and all other intellectual property
rights, and applications filed with respect to such rights, and any and all
other intangible property and property rights owned or used by Seller or in
which Seller has any rights or licenses, including, without limitation, the
property described in Section 1.1(e) above. Seller's use of the property
described in this Section 3.8 is not governed by or pursuant to a license or
similar agreement from any third party. Seller owns or has the right to use all
such rights necessary for the operation of the Business. Seller has taken all
reasonable security measures to protect the secrecy, confidentiality, and value
of its trade secrets. With respect to each such item:

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<PAGE>   8

                  (a) Seller owns and possesses all right, title and interest in
         and to the item;

                  (b) no charge, complaint, action, suit, proceeding, hearing,
         investigation, claim or demand has been instituted, is pending or, to
         Seller's knowledge, is threatened, which challenges the legality,
         validity, enforceability, use or ownership of the item;

                  (c) to Seller's knowledge, the Seller's use of such item does
         not interfere with, infringe upon, misappropriate or otherwise conflict
         with the rights of others, and such item is not being interfered with,
         infringed upon, misappropriated or violated by others and is not
         subject to any outstanding judgment, order, decree, stipulation,
         injunction or charge;

                  (d) Seller has never received any charge, complaint, claim or
         notice of interference, infringement, misappropriation or violation
         with respect to the item;

                  (e) no license, agreement or permission pertaining to the item
         has been granted by Seller; and

                  (f) Seller has not agreed to indemnify any person or entity
         for or against any interference, infringement, misappropriation or
         violation with respect to any item described in Section 1.1(e) hereof
         being assigned to Purchaser.

         3.9 INVENTORY. Seller's inventory, as shown on the Statements, is
merchantable and fit for the purpose for which it was procured or manufactured,
useable and, if applicable to the Business, saleable in the ordinary course of
the Business, is not obsolete or surplus, and is carried on the Statements at an
amount not in excess of the lower of cost or net realizable value. As used in
the foregoing sentence, "obsolete inventory" is inventory which, at the date of
the Statement, was not usable or saleable because of legal restrictions, failure
to meet specifications, loss of market, damage, physical deterioration or for
any other cause; and, "surplus inventory" is inventory that, at the date of the
Statement, exceeded known or anticipated requirements in the reasonable business
judgment of Seller.

         3.10 CONTRACTS. Set forth in the Disclosure Statement is a true,
complete and accurate list of all material agreements, leases and contracts
concerning or relating to the Business and to which Seller is a party or to
which the Assets are subject, whether oral or written (the "Business
Contracts"). Except for the Business Contracts, Seller is not a party to any
written or oral agreement, lease or contract affecting or relating to the Assets
or the Business the Assets in any material way. The Business Contracts
constitute all material agreements, documents and leases necessary for the
operation of the Business as presently conducted. Seller has delivered to
Purchaser true and correct copies of all such written Business Contracts and a
comprehensive summary of all such Business Contracts which are oral. All of the
Assumed Business Contracts are valid, in full force and effect, and enforceable
in accordance with their terms, and except as expressly prohibited therein, all
of the Assumed Business Contracts are assignable to Purchaser in accordance with
their terms. None of the Assumed Business Contracts have been terminated or
canceled by Seller or the other parties thereto with respect to the current year
or future years.

                                      -8-

<PAGE>   9

Further, no party to an Assumed Business Contract has limited
its business relationship with Seller in any material respect. No party to any
Assumed Business Contract is in material default, nor has any notice of default
been received by Seller, and, to Seller's knowledge, there exists no event,
condition or occurrence which, after notice or lapse of time, or both, would
constitute a material default under any Assumed Business Contract. Seller and
every other party to the Assumed Business Contracts have in all material
respects performed or are performing all obligations required to be performed by
them. This Agreement and the consummation of the transactions contemplated
herein will not violate or cause a default under any of the Assumed Business
Contracts, subject to obtaining the consents to the assignment of the Assumed
Business Contracts from the other parties thereto to the extent required by the
terms of such Assumed Business Contracts or by law.

         3.11 COMPLIANCE WITH LAWS; PERMITS AND LICENSES. Seller is in
substantial compliance with all applicable laws, rules, regulations and orders
applicable to it, its operation of the Business, or the Assets. To the Seller's
knowledge, the present uses by Seller of the Assets in the operation of the
Business do not violate any laws, rules, regulations or orders, including
without limitation, any applicable building, zoning, occupancy, use,
environmental, antitrust, safety, health, employment discrimination, or other
law, ordinance or regulation. The Disclosure Schedule lists all federal, state,
local and foreign governmental franchises, permits, licenses or other
authorizations held by Seller, all of which are in full force and effect, and
true copies of which have been delivered to Purchaser. No action or proceeding
seeking the revocation or suspension of any such permits, licenses, franchises
or authorizations are pending or, to Seller's knowledge, threatened.

         3.12 INSURANCE.

                  (a) The Disclosure Schedule sets forth all insurance policies
         currently maintained by Seller, including, without limitation, if in
         effect, policies of property insurance including coverage for acts of
         God and government insurrection, fidelity insurance, general liability
         including libel and slander insurance, automobile liability insurance,
         workers compensation insurance and excess coverage above any or all of
         those insurance policies. True, correct and complete copies of all
         insurance policies listed in the Disclosure Schedule have been
         delivered to Purchaser. All current insurance policies will be in full
         force and effect through the Closing Date except as otherwise disclosed
         in the Disclosure Schedule. Those policies scheduled to expire before
         the Closing Date will be renewed or replaced with comparable coverage.
         Except as set forth in the Disclosure Schedule, to Seller's knowledge,
         no event has occurred forming the basis of any present property,
         casualty, fidelity, liability or workers compensation claim against
         Seller which has not been reported to the appropriate carrier, is not
         fully covered by insurance or which may reasonably be expected to
         exceed the available limits of liability of the applicable insurance
         policy or policies.

                  (b) There has been no material breach of any of Seller's
         obligations under any of the insurance policies referred to in the
         Disclosure Schedule. All policies listed in the Disclosure Schedule are
         carried in amounts and with carriers sufficient to fulfill the

                                      -9-
<PAGE>   10

         requirements of the Business Contracts and all laws or ordinances in
         effect in jurisdictions or locations where the Seller conducts business
         and which require Seller to maintain such coverage. During the past
         five years Seller has not been denied insurance coverage or had
         insurance coverage revoked or rescinded by a carrier. There are no
         outstanding requirements or recommendations by any insurance company
         that issued any policy of insurance to Seller or by any board of fire
         underwriters or other similar body or by any governmental authority
         exercising similar functions which require or recommend any changes in
         the conduct of Seller's business or any repairs or other work to be
         done with respect to any of its assets or properties.

         3.13 EMPLOYEES. The Disclosure Schedule contains a complete and
accurate list of: (i) all of Seller's employees which perform services or duties
in connection with the Business (the "Business Employees"); (ii) each such
Business Employee's salary or hourly rate, annual bonus, if any, and commission
rate and annual commission amount, for the calendar years ending December 31,
1996 and for the current year (with actual amounts through May 31, 1997 and
estimated amounts for the year ending December 31, 1997); (iii) all fringe
benefits or incentive pay received by each Business Employee within each such
period; and (iv) any bonus or other payment earned but not yet paid such
Business Employee. From May 31, 1997 through the Closing Date, Seller will not
increase the compensation payable or to become payable, or the benefits provided
to, any Business Employee except in the ordinary course of business consistent
with past practices and only after prior notice to Purchaser. There are no
written or oral collective bargaining or other employment agreements or
understandings with or affecting any employee of Seller. All accrued vacation,
sick days and personal days due Seller's Business Employees terminate as of the
anniversary date of each such Business Employee's employment with the Seller. To
Seller's knowledge, there are no charges with respect to or relating to the
Business pending before the Equal Employment Opportunity Commission or any
agency relating to unlawful employment practices.

         3.14 EMPLOYEE BENEFITS. Except for those plans and agreements expressly
identified in Section 3.14 of the Disclosure Schedule (collectively, the
"Employee Benefit Plans"), Seller is not a party to or bound by any profit
sharing, stock option, pension, severance, retirement, stock purchase,
hospitalization, group or individual life, disability or health insurance, or
employee welfare benefit or similar plan or agreement providing benefits to the
current or former employees, directors, officers, agents or shareholders of
Seller. True and correct copies of each Employee Benefit Plan, all amendments
thereto, all summary plan descriptions thereof, amendments to such summaries and
summaries of material modifications thereof have been delivered to Purchaser.
Seller shall timely pay all amounts due under or with respect to the Employee
Benefit Plans, and Seller does not, nor will it prior to the Closing Date,
participate in, contribute to, nor employ any persons covered by a multiemployer
plan, as defined in Section 3(37) of the Employee Retirement Income Security Act
of 1974, as amended ("ERISA"), and has not, and will not, prior to the Closing
Date, incur any withdrawal liability within the meaning of Title IV of ERISA.
Seller has materially complied with, and will through and after the Closing
Date, continue to materially comply with the Employee Benefit Plans and all
requirements of law relating thereto and Purchaser shall have no liability or
responsibility whatsoever with respect to the Employee Benefit Plans.

                                      -10-
<PAGE>   11

         3.15 ENVIRONMENTAL, HEALTH AND SAFETY MATTERS. Seller has complied in
all material respects with all laws (including rules and regulations thereunder)
of all applicable federal, state, local and foreign governments, and their
respective agencies, concerning the environment, public health and safety and
employee health and safety, and no charge, complaint, action, suit, proceeding,
hearing, investigation, claim, demand or notice has been filed or commenced
against any of them alleging any failure to comply with any such law or
regulation, including, limiting, without limitation, the Comprehensive
Environmental Response, Compensation and Liability Act of 1980, the Federal
Water Pollution Control Act of 1972, the Clean Air Act of 1970, the Safe
Drinking Water Act of 1974, the Toxic Substances Control Act of 1976, the Refuse
Act of 1989, the Emergency Planning and Community Right-to-Know Act of 1986, the
Federal Resource Conservation and Recovery Act, the Michigan Natural Resources
and Environmental Protection Act and any of its subparts and Pollution Control
Act, each as amended, or any other law of any government or agency concerning
the storage, treatment, handling, transport, disposal, or the release or
threatened release of hazardous substances or hazardous materials, public health
and safety or pollution or protection of the environment (collectively, the
"Environmental Statutes").

         3.16 LITIGATION. The Disclosure Schedule sets forth each instance in
which Seller or any officer, director or employee of Seller in their capacities
as such, or the Business or the Assets (i) is subject to any unsatisfied
judgment, order, decree, stipulation, injunction or charge of, or (ii) is a
party or subject to or, to Seller's knowledge, is threatened to be made a party
or subject to any charge, complaint (including any charging libel), action,
suit, proceeding, hearing or investigation in any court or quasi-judicial or
administrative agency of any federal, state, local or foreign jurisdiction or
before any arbitrator. Seller has no any reason to believe that any such charge,
complaint, action, suit, proceeding, hearing or investigation may be brought or
threatened against Seller or any of its officers, directors or employees, or the
Assets or Business.

         3.17 WARRANTIES. All products manufactured by the Company are in
conformity with all applicable contractual commitments and all express and
implied warranties, and Seller has no liability (and there is no basis for any
present or future charge, complaint, action, suit, proceeding, hearing,
investigation, claim or demand against Seller giving rise to any liability) for
replacement of any such products or other damages in connection therewith.

         3.18 CONSENTS. Except as set forth in the Disclosure Schedule, no
consent, approval or authorization of or designation, declaration or filing
with, any governmental authority or agency is required on the part of Seller in
connection with the valid execution and delivery of this Agreement or the
consummation of the transaction herein contemplated.

         3.19 BROKERS' FEE. Seller will not be liable for any business broker's
fee or similar fees or expenses in connection with the transaction contemplated
in this Agreement.

         3.20 ASSETS; TITLE. Upon consummation of the transactions contemplated
in this Agreement, Purchaser will acquire title to all of the Assets, free and
clear of all Liens. The Assets consist of all properties and assets necessary
for the operation of the Business as presently conducted by Seller, and no
officer, director, employee, shareholder or affiliate of Seller owns or

                                      -11-

<PAGE>   12
has an interest in any properties or assets necessary for the operation of the
Business as presently conducted.

         3.21 DISCLOSURE. No representation or warranty by the Seller contained
in this Agreement and no statement contained in any certificate or other
instrument furnished or to be furnished pursuant hereto or in connection with
the transaction contemplated hereby, contains or will contain any untrue
statement of a material fact, or omits or will omit, to state a material fact
necessary in order to make any of the statements not misleading, or necessary in
order to provide Purchaser with all pertinent information regarding the Assets
or the Business.

                                   ARTICLE IV

             REPRESENTATIONS, WARRANTIES AND COVENANTS OF PURCHASER

         Purchaser understands that each of the following representations and
warranties are material and have been relied on by Seller. Purchaser represents,
warrants and covenants to Seller that the statements contained in this Article
IV are correct and complete as of the date of this Agreement and will be correct
and complete as of the Closing Date (as though made on the Closing Date).

         4.1 POWER AND AUTHORITY. The Purchaser has, and at the Closing Date
will have, all requisite power and authority to enter into this Agreement and
all other instruments and agreements contemplated hereby, and to carry out and
perform its obligations under this Agreement. The execution of this Agreement
and the consummation of the transactions contemplated have been duly authorized
and approved by Purchaser's Board of Directors. This Agreement constitutes, and
all agreements and instruments contemplated hereby when executed and delivered
in accordance with the terms of this Agreement will constitute, valid and
binding obligations of Purchaser, enforceable in accordance with their
respective terms, except to the extent limited by bankruptcy, insolvency, and
other laws of general application relating to or affecting the enforcement of
creditors' rights and general equity principles.

         4.2 ABSENCE OF VIOLATIONS. Neither the execution, delivery, performance
or compliance with this Agreement and all other agreements contemplated hereby,
nor the consummation of the transactions herein contemplated, will (i) violate,
conflict with, or constitute a default or breach of Purchaser's Certificate of
Incorporation, bylaws or other constituent documents, or (ii) constitute a
violation by Purchaser of any law, rule, regulation, ordinance, order, writ,
injunction, decree or judgment applicable to Purchaser, or result in any breach
or violation of, or be in conflict with or constitute a default under, any
mortgage, indenture, contract, agreement, lease, or instrument in any way
binding on Purchaser.

         4.3 CONSENTS. On or prior to Closing, all consents, approvals or
authorizations of or designations, declarations or filings with, any
governmental authority or agency required on the part of Purchaser in connection
with the valid execution and delivery of this Agreement or the consummation of
the transactions herein contemplated will be obtained, except as may be
necessary for Purchaser to continue the operation of the Business, which will be
obtained as soon as practical after Closing.

                                      -12-

<PAGE>   13

         4.4 BROKERS' FEE. Purchaser is not liable for any business broker's
fee, or similar fee or expense, in connection with the transaction contemplated
in this Agreement.

                                    ARTICLE V

            CONDITIONS PRECEDENT TO PURCHASER'S OBLIGATION AT CLOSING

         The obligation of Purchaser to consummate the transactions contemplated
by this Agreement at the Closing is subject to the satisfaction of all of the
following conditions, any of which may be waived in writing by Purchaser:

         5.1 LIEN RELEASES. Purchaser shall be satisfied with the UCC-3
Termination Statements to be delivered pursuant to Section 7.2(f) below.

         5.2 ACCURACY OF REPRESENTATIONS. All representations and warranties
made by Seller in this Agreement shall have been true and correct in all
material respects on the date of this Agreement and shall be true and correct in
all material respects on the Closing Date with the same force and effect as if
they had been made on and as of said date.

         5.3 PERFORMANCE OF AGREEMENT. Seller shall have performed and complied
with all of its obligations under this Agreement which are to have been
performed or complied with on or prior to the Closing Date, and Seller and
Stiegman shall have executed and delivered all of the documents contemplated in
this Agreement, all of which shall be satisfactory to Purchaser.

         5.4 CONSENTS AND WAIVERS. Seller shall have obtained all consents,
authorizations, approvals and waivers necessary for the consummation of the
transaction contemplated in this Agreement.

         5.5 BOARD APPROVAL. The transactions herein contemplated shall have
been approved by the requisite vote at meetings of the Board of Directors.

         5.6 DUE DILIGENCE. Purchaser shall have completed and be satisfied with
the results of its due diligence investigation of Seller's assets, liabilities
and prospects in its sole discretion.

         5.7 TERMINATION. This Agreement shall not have been terminated pursuant
to Section 12.1 of this Agreement.

         5.8 NBD CONSENT. NBD Bank, as Purchaser's senior secured creditor shall
consent to the transaction.

         5.9 TAX CLEARANCE REQUEST. Within three (3) business days of the date
of this Agreement, Seller shall have completed, executed and filed a (i) Tax
Letter Request (Michigan Department of Treasury Form C-3351) with the Michigan
Department of Treasury, and (ii) a request for clearance of account with the
Michigan Employment Security Association ("MESA").

                                      -13-
<PAGE>   14

Seller shall promptly deliver a copy of the Tax Letter and the MESA to Purchaser
upon receipt of the Tax Letter and the clearance of account from the Michigan
Department of Treasury and the MESA, respectively.

                                   ARTICLE VI

             CONDITIONS PRECEDENT TO SELLER'S OBLIGATION AT CLOSING

         The obligation of Seller to consummate the transactions contemplated by
this Agreement at the Closing is subject to the satisfaction of all of the
following conditions, any of which may be waived in writing by Seller:

         6.1 ACCURACY OF REPRESENTATIONS. All representations and warranties
made by Purchaser in this Agreement shall have been true and correct in all
material respects on the date of this Agreement and shall be true and correct in
all material respects on the Closing Date with the same force and effect as if
they had been made on and as of said date.

         6.2 PERFORMANCE OF AGREEMENT. Purchaser shall have performed and
complied with all of its obligations under this Agreement which are to have been
performed or complied with on or prior to the Closing Date, and Purchaser shall
have executed and delivered all of the documents contemplated in this Agreement,
all of which shall be satisfactory to Seller.

         6.3 -[intentionally omitted]-

         6.4 SHAREHOLDER AND BOARD APPROVAL. Seller shall have obtained the
requisite approval of its Board of Directors and shareholders to effect the
transactions contemplated by this Agreement.

                                   ARTICLE VII

                                     CLOSING

         7.1 The closing (the "Closing") of the transactions contemplated in
this Agreement will be held at the offices of Purchaser's counsel, Jaffe, Raitt,
Heuer & Weiss, Professional Corporation, One Woodward Avenue, Suite 2400,
Detroit, MI 48226, as soon as reasonably possible following the negotiation and
preparation of this Agreement and the attendant documents and after the
conditions set forth in the documents and in Article V and Article VI of this
Agreement are satisfied. The date on which the Closing is held is referred to in
this Agreement as the "Closing Date". In any event, the Closing shall occur no
later than June 30, 1997.

         7.2 At the Closing, Seller shall deliver or cause to be delivered to
Purchaser:

                  (a) A certificate of an officer of Seller, certifying that (i)
         all of the representations and warranties of Seller set forth in this
         Agreement were true, correct and

                                      -14-
<PAGE>   15

         complete in all material respects on the date of this Agreement, and
         are true, correct and complete in all material respects on the Closing
         Date, (ii) Seller has complied with all of its duties and obligations
         under this Agreement which were to have been performed prior to the
         Closing Date, (iii) and that the resolutions of Seller's Board of
         Directors and shareholders approving the terms and conditions of this
         Agreement and the sale of the Assets as herein provided, a true,
         correct and complete copy of which shall be attached to such
         certificate, have not been altered, amended or repealed, and are in
         full force and effect. The form and content of such certificate shall
         be satisfactory to Purchaser.

                  (b) A Warranty Bill of Sale, Assignment and Assumption
         Agreement transferring all of the Assets to Purchaser, in the form
         attached hereto as Document 7.2(b) (the "Warranty Bill of Sale,
         Assignment of Assumption Agreement").

                  (c) All of the Assets.

                  (d) The Escrow Agreement.

                  (e) The Employment Agreement.

                  (f) UCC-3 Termination Statements in a form suitable for filing
         with the Michigan Secretary of State executed by Comerica Bank,
         releasing any and all Liens which Comerica Bank may in or on the
         Assets. The form and contents of such UCC-3 Termination Statements
         shall be satisfactory to Purchaser in its sole and absolute discretion.

                  (g) A copy of the Comerica Escrow Agreement.

                  (h) Such other documents and instruments as may be reasonably
         requested by counsel for Purchaser.

         7.3 At the Closing, Purchaser shall deliver or caused to be delivered
to Seller:

                  (a) A certificate of an officer of Purchaser, certifying that
         (i) all of the representations and warranties of Purchaser set forth in
         this Agreement were true, correct and complete in all material respects
         on the date of this Agreement, and are true, correct and complete in
         all material respects on the Closing Date, (ii) Purchaser has complied
         with all of its duties and obligations under this Agreement which were
         to have been performed prior to the Closing Date, (iii) and that the
         resolutions of Purchaser's Board of Directors approving the terms and
         conditions of this Agreement and the sale of the Assets as herein
         provided, a true, correct and complete copy of which shall be attached
         to such certificate, have not been altered, amended or repealed, and
         are in full force and effect. The form and content shall be
         satisfactory to Seller.

                                      -15-
<PAGE>   16

                  (b) The Closing Payment by cashier's check or wire transfer
         and the Shares, and the amounts to be placed in the escrow accounts
         created under the Escrow Agreement and the Comerica Escrow Agreement.

                  (c) A stock certificate evidencing the issuance of Eighty-Five
         Thousand (85,000) shares of Purchaser's common stock.

                  (d) The Option Agreement.

                  (e) The Warranty Bill of Sale, Assignment and Assumption
         Agreement.

                  (f) The Escrow Agreement.

                  (g) The Employment Agreement.

                  (h) Such other documents and instruments as may be reasonably
         requested by counsel for Seller.

                                  ARTICLE VIII

                                 OTHER COVENANTS

         8.1 ACCESS TO INFORMATION. Between the date of this Agreement and the
Closing, Seller shall cause its officers, directors, employees and agents to
give Purchaser and its counsel, accountants, agents and other representatives
full access, during normal business hours, to all of the assets, properties,
books of account, leases, agreements, commitments, tax returns, and records of
Seller and to furnish Purchaser or its representatives with all such information
concerning Seller as Purchaser may request.

         8.2 BEST EFFORTS. From the date hereof and prior to the Closing, Seller
will use its best efforts, and will cooperate with Purchaser, to secure all
necessary consents, approvals, authorizations, exemptions and waivers from third
parties as shall be required in order to enable Seller to effect the
transactions contemplated hereby, and will otherwise use its best efforts to
cause the consummation of such transactions in accordance with the terms and
conditions hereof.

         8.3 COVENANT NOT TO COMPETE. As a necessary inducement to cause
Purchaser to enter into this Agreement, Seller and Stiegman each covenants,
warrants and agrees, contingent on the Closing, that they shall not, either
directly or indirectly:

                  (a) for a period of three (3) years (the "Covenant Period")
         commencing on the Closing Date, engage in, or have any interest in or
         be associated with (whether as an officer, director, shareholder,
         partner, associate, employee, consultant, owner or otherwise) any
         corporation, partnership, trust, association, firm, limited liability
         company or enterprise which is engaged in, the Business, any facet
         thereof or any business, venture or enterprise which during the term
         hereof competes with the Purchaser or any affiliate

                                      -16-
<PAGE>   17

         thereof, anywhere in the United States; except that Seller and Stiegman
         may invest in any publicly-held corporation engaged in any similar
         business, if their aggregate investment in such corporation does not
         exceed one (1%) percent in value of the issued and outstanding capital
         stock of such corporation;

                  (b) use, directly or indirectly, the BioPhotonics name for or
         in connection with any business related to electrophoresis;

                  (c) divert, or by aid of others, do anything which would tend
         to divert from the Business, any trade or business with any customer
         with whom Purchaser, Seller or Stiegman had any contact or association
         in connection with the Business;

                  (d) solicit, induce or attempt to induce any employee of the
         Purchaser to enter into the employ of: (i) Stiegman or Seller, (ii) any
         entity in which Stiegman is an employee or in which Stiegman or Seller
         has a financial interest, or (iii) any competitor of the Purchaser; or
         to solicit, induce, or attempt to induce any person employed by
         Purchaser in connection with the Business to leave the employment of
         the Purchaser;

                  (e) employ or otherwise contract for the services of any
         individual who was or currently is an employee of Purchaser at any time
         during the period from one (1) year prior to the date of this Agreement
         through the expiration of the Covenant Period, without first securing
         the written consent of Purchaser; or

                  (f) use, publish, disseminate, distribute or otherwise
         disclose any proprietary or confidential information of Purchaser, of
         whatever kind or nature, including, without limitation, information
         relating to the Business, trade secrets, licensing or know-how
         agreements, marketing strategies, heat treating processes, methods,
         machinery, equipment, distribution processes, source of goods and
         materials, goods and material purchasing, operating and other cost
         data, customer lists and customer contact personnel, terms and
         conditions of agreements to which Purchaser is a party, and any other
         information which is not generally known in the industry.

         The parties acknowledge that Seller may continue to develop and
manufacture digital electronic camera products and may sell such to end-users
who do not directly compete with Purchaser, as well as to distributors in the
ordinary course of business.

         The covenants set forth in Section 8.3 will not be enforceable against
Stiegman if he is terminated by the Company, unless he is terminated for cause.
Solely with respect to this Agreement, cause shall be defined as fraud,
dishonesty, or other misconduct in the performance of his duties and
responsibilities as an employee of Purchaser.

         The parties intend that the covenant set forth in this Section 8.3
shall be deemed to be a series of separate covenants with respect to the
Business. The parties acknowledge and agree that the covenants set forth above
are reasonable and valid in geographical and temporal scope and in all

                                       17

<PAGE>   18

other respects. The parties covenant and agree that in the event of the
violation or attempted violation of this Section 8.3, in addition to any and all
legal and equitable remedies immediately available, this Section 8.3 may be
enforced by a temporary and/or permanent injunction in an action in equity.
Seller and Stiegman acknowledge that the remedy at law for a breach or
threatened breach of this Section 8.3 would be inadequate.

                                   ARTICLE IX

                   INVESTIGATION, SURVIVAL AND INDEMNIFICATION

         9.1 INVESTIGATION. The investigation by Purchaser and its employees,
agents and representatives, of the assets, business and records, including tax
returns, of Seller (including, without limitation, investigation of titles to,
and the existence and condition of the Assets), prior to or subsequent to the
Closing Date, shall not negate or diminish the representations and warranties of
Seller contained or provided for herein except to the extent Purchaser gains
actual knowledge of an inaccurate warranty or representation.

         9.2 SURVIVAL. The representations and warranties made in this Agreement
and in any agreement or instrument executed and delivered in connection herewith
shall survive the Closing Date.

         9.3 INDEMNIFICATION OF PURCHASER. Seller and Stiegman hereby agree to
jointly and severally indemnify, defend, and hold Purchaser and its officers,
directors, shareholders, employees, successors and assigns, harmless from and
against any and all liabilities, losses, costs and expenses which Purchaser may
suffer and become liable for as a result of or in connection with:

                  (a) Any and all liabilities and obligations of, or claims
         against, Seller not expressly assumed by Purchaser pursuant to the
         provisions of this Agreement, including without limitation, (i) any and
         all liabilities and obligations of, or claims, demands, liens, or
         judgments against Purchaser incurred or which arise from or in any way
         relate to the activities of Seller, or the operation of the Business by
         Seller (including claims for product liability, bodily injury or
         property damage), (ii) any and all obligations to any employees of
         Seller (except to the extent such obligations constitute a part of the
         Assumed Employee Liabilities), including, without limitation,
         arbitration claims, unfair labor practice charges, claims under the
         Employee Benefit Plans, claims for post-termination or post-retirement
         medical benefits or claims for severance pay if Seller terminates any
         such employees concurrently with the consummation of the transaction
         herein contemplated, whether Purchaser employs such employees
         subsequent to the Closing Date or not, or (iii) any and all liabilities
         and obligations of Seller to report and pay amounts due for payroll,
         employment, social security or other taxes attributable to or arising
         with respect to employees of Seller or their employment or independent
         contractors treated as, or deemed to be, employees of Seller;

                                       18

<PAGE>   19

                  (b) Any and all liabilities, obligations, or claims against
         Purchaser arising from, in connection with or as a result of (i) the
         failure of the Seller to file any tax returns or reports required to be
         filed by Seller in connection with the Business or Assets, or (ii) the
         failure of Seller to pay all taxes required by such reports or returns,
         including all income, gross receipts, excise, import, property,
         franchise, ad valorem, license, sales, use, and withholding taxes
         required;

                  (c) Any and all monetary damages or deficiency resulting from
         any misrepresentation, breach of warranty, and/or nonfulfillment of any
         agreement or covenant on the part of Seller, under this Agreement or
         resulting from any misrepresentation or omission from any certificate,
         schedule, list, or other instrument to be furnished by Seller to
         Purchaser under this Agreement;

                  (d) The failure of Seller to operate or otherwise conduct the
         Business in compliance with all applicable laws, statutes, ordinances,
         rules or regulations of any foreign, federal, state or local government
         or governmental agency;

                  (e) Any and all liabilities, obligations or claims arising
         under the Environmental Statutes prior to closing;

                  (f) Any and all actions, suits, proceedings, demands,
         assessments, judgments, costs, and expenses including reasonable
         attorneys' fees, incident to any of the foregoing; and

                  (g) Any claim asserted against Purchaser by any third party
         relating to any liability or obligation of Seller not expressly assumed
         by Purchaser hereunder.

         9.4 INDEMNIFICATION OF SELLER. Purchaser hereby agrees to indemnify and
hold Seller, its shareholders, officers, directors, successors and assigns,
harmless from and against any and all liability, loss, cost or expense which
Seller may suffer or become liable for as a result of or in connection with:

                  (a) Any and all liabilities and obligations of, and claims,
         demands, liens and judgments against Seller incurred, or which arise
         from or in any way relate to the activities of Purchaser, solely as a
         result of the operation of the Business by Purchaser after the Closing
         Date;

                  (b) Any and all liabilities and claims arising under any
         contract, agreement or lease, the obligations of which are expressly
         assumed by Purchaser pursuant to the terms of this Agreement;

                  (c) Any and all actions, suits, proceedings, demands,
         assessments, judgments, costs, and expenses including reasonable
         attorneys' fees, incident to any of the foregoing and

                                       19

<PAGE>   20

                  (d) Any and all monetary damages or deficiency resulting from
any misrepresentation, breach of warranty, and/or nonfulfillment of any
agreement or covenant on the part of Purchaser, under this Agreement or
resulting from any misrepresentation or omission from any certificate, schedule,
list, or other instrument to be furnished by Purchaser to Seller under this
Agreement

         9.5 ARBITRATION.

                  (a) If a party hereto has any claim against any other party
         hereto under this Agreement, the party seeking recovery shall set forth
         the amount of the claim and the circumstance in a written demand to the
         party from whom recovery is sought (the "Demand"). If the party from
         whom recovery is sought gives the party seeking recovery a written
         rejection of the Demand within thirty (30) days of its receipt of the
         Demand, then the claim shall be submitted to arbitration under Section
         9.5(b). If the party from whom recovery is sought does not give the
         party seeking recovery a written rejection of the Demand within thirty
         (30) days of its receipt of the Demand, then the validity and the
         amount of the claim set forth in the Demand shall be conclusive and
         shall be due and payable from the party from whom recovery is sought.

                  (b) If the party from whom recovery is sought gives the party
         seeking recovery a written rejection of the Demand, as set forth in
         Section 9.5(a), then the parties shall submit the claim set forth in
         the Demand to binding arbitration, in the Detroit, Michigan area under
         the Commercial Arbitration Rules of the American Arbitration
         Association ("AAA") then obtaining before a panel of three arbitrators.
         The award rendered by the arbitrators shall be final and binding, and a
         judgment may be entered upon such award in a court of competent
         jurisdiction. All of the parties to this Agreement hereby consent to
         the jurisdiction of the courts of the State of Michigan for purposes of
         entering judgment with respect to such award. Once any award shall be
         made hereunder (and shall become final), the parties shall promptly
         comply with the terms of such award and shall share equally the cost of
         arbitration; provided, however, if the arbitrators find 100% in favor
         of one party, then the losing party shall pay the entire cost of
         arbitration and reimburse the prevailing party for all of its actual
         costs incurred including attorney fees.

                  (c) The provisions of this Section 9.5 are permissive, and a
         failure of Purchaser to withhold and set off any amounts so provided
         above shall not affect any obligation of the Seller hereunder.

         9.6 SETOFF. During the period beginning on the date of this Agreement
and ending on the first anniversary of such date, any amounts payable by
Purchaser to Seller or Stiegman under this Agreement or any other document,
instrument or agreement executed in connection with the transactions
contemplated in this Agreement may, at the option of Purchaser, be set off
against any amounts due Purchaser by Seller under this Agreement or any
documents, instruments or agreements executed in connection with the
transactions contemplated in this Agreement. Purchaser shall be entitled to
cancel any of the Shares, at a rate of seven cents ($.07) per share, as

                                       20
<PAGE>   21

a set off against any amounts payable by Seller to Purchaser under this
Agreement or any documents, instruments or agreements executed in connection
with the transactions contemplated in this Agreement. In addition, Purchaser
shall be entitled to cancel any of the common stock of Purchaser issued to
Seller pursuant to the Option Agreement, at a rate of seven cents ($.07) per
share, as a set off against any amounts payable by Seller to Purchaser under
this Agreement or any documents, instruments or agreements executed in
connection with the transactions contemplated in this Agreement.

                                    ARTICLE X

                           DESTRUCTION OR CONDEMNATION

         10.1 DESTRUCTION. In the event any part of the Assets shall be damaged
or destroyed prior to the Closing Date, Seller shall notify Purchaser thereof,
which notice shall include a description of the damage and all pertinent
insurance information.

                                   ARTICLE XI

                                   TERMINATION

         11.1 TERMINATION. This Agreement may be terminated at any time before
the Closing:

                  (a) by mutual consent of Purchaser and Seller; or

                  (b) by Purchaser for any reason or no reason upon delivery of
         notice to Seller within the Due Diligence Period; or

                  (c) by Purchaser if any of the conditions set forth in Article
         V of this Agreement have not been fulfilled, satisfied or waived by
         June 30, 1997;

                  (d) by Seller if any of the conditions set forth in Article V
         of this Agreement have not been fulfilled, satisfied or waived by June
         30, 1997; or

                  (e) by Purchaser, in the event that any part of the Assets are
         damaged or destroyed prior to the Closing Date and the use of the
         Assets or the operation of the Business is materially affected or such
         damage or destruction or the cost to repair the same exceeds Twenty-
         Five Thousand ($25,000.00) Dollars.

         11.2 EFFECT OF TERMINATION. If this Agreement is terminated in
accordance with Section 11.1 of this Agreement, it shall be null and void and
have no further force or effect, except as provided in the immediately following
sentence and in Article IX, which provisions shall survive any such termination
and continue in effect thereafter. In the event a party terminates this
Agreement as a result of a material breach by the other party, then such party
shall be entitled to recover from the defaulting party all out-of-pocket
expenses incurred by it and any

                                       21
<PAGE>   22

of its affiliates (including, without limitation, legal and accounting fees and
expenses) in connection with (a) the preparation, drafting and negotiation of
this Agreement and any other document related to the transactions contemplated
hereunder (the "Professional Expenses") and (b) the due diligence review by
Purchaser and its affiliates of Seller's business, properties, operations and
financial condition; provided that the parties agree that a failure to satisfy
the condition precedent contained in Section 6.1 shall not be deemed a material
breach of this Agreement if such failure shall relate to a representation and
warranty which either (i) was true and correct as of the date of this Agreement
but became not true and correct as of the Closing due to intervening events,
acts or omissions not within the control of the party making such representation
and warranty or (ii) shall be curable and the party making such representation
and warranty shall agree, in writing, to cure such breach within a reasonable
time period acceptable to the other party and to indemnify and hold harmless the
other party in the manner, and to the extent set forth in Article IX.

         11.3 EXPENSES AND LIABILITY. Except as otherwise provided in this
Agreement, each of the parties will pay its own costs and expenses relating to
the transactions provided for in this Agreement irrespective of when incurred.

                                   ARTICLE XII

                                  MISCELLANEOUS

         12.1 NOTICES. All notices, elections, demands, requests, consents,
approvals, statements or other communications (collectively, "notices or
demands") upon any party hereto desired or required to be given under any of the
provisions hereof shall be given or made only by being in writing and: (i)
delivered personally to the party to whom it is directed, or (ii) sent by first
class mail or overnight express mail, postage and charges prepaid, addressed to
the party to whom it is directed, at the following addresses, or at such other
address as the parties may hereafter indicate by written notice as provided
herein.

         IF TO SELLER OR STIEGMAN:              WITH A REQUIRED COPY TO:

         BioPhotonics Corporation               Pierce & Hahn
         P.O Box 3756                           709 Huron St.
         Ann Arbor, Michigan 48106              Suite 200
         Attn: Jeff Stiegman                    Ann Arbor, Michigan 48103
                                                Attn: Richard W. Pierce, Esq.

                                       22
<PAGE>   23

         IF TO PURCHASER:                       WITH A REQUIRED COPY TO:

         B.I. Systems Corporation               Jaffe, Raitt, Heuer & Weiss
         525 Avis Drive, Suite 10               Professional Corporation
         Ann Arbor, Michigan 48108              Suite 2400
         Attn:  Jeff Williams                   One Woodward Avenue
         phone (313) 930-9900                   Detroit, MI  48226
         fax (313) 930-0990                     Attn: Peter Sugar, Esq.

Except as otherwise provided in this Agreement, any such notice or demand (x)
given or made in the manner indicated in clause (i) of this Section 12.1 shall
be deemed to be given or made on the day on which it was delivered; and (y)
given or made in the manner indicated in clause (ii) of this Section 12.1 shall
be deemed to be given or made on the second business day after the day on which
it was deposited in a regularly maintained receptacle for the deposit of the
United States mail, or in the case of overnight express mail, on the business
day immediately following the day on which it was deposited in a regularly
maintained receptacle for the deposit of overnight express mail.

         12.2 HEADINGS. The headings contained in this Agreement are for
reference purposes only and shall not in any way affect the meaning or
interpretation of this Agreement.

         12.3 CONSTRUCTION. This Agreement has been executed in, and shall be
construed and enforced in accordance with the laws of the State of Michigan,
with regard to such state's conflicts of laws doctrine. Seller and Purchaser
acknowledge that each of them has equally participated in the final wording of
this Agreement. Accordingly, the parties agree that this Agreement shall be
construed equally against each party, and shall not be more harshly construed
against the party by reason of the fact that the particular party's counsel may
have prepared this, the final version of the Agreement between the parties
hereto.

         12.4 BENEFIT. This Agreement shall be binding upon and inure to the
benefit of the parties hereto and their respective heirs, personal
representatives, successors and assigns.

         12.5 ENTIRE AGREEMENT. This Agreement, including the Exhibits,
Documents, Disclosure Schedule and the Purchaser's Disclosure Schedule attached
or to be attached hereto, is and shall be deemed to be the complete and final
expression of the agreement between the parties as to the matters herein
contained and relative thereof, and supersedes any previous agreements between
the parties pertaining to such matters.

         12.6 SEVERABILITY. If any part of this Agreement is held to be invalid
or unenforceable under the laws of any jurisdiction where this Agreement is to
be governed or sought to be enforced, the remaining provisions shall be
enforceable to the maximum extent permitted by law; provided, the remaining
provisions effectuate the intent of the parties as manifested herein.

                                       23
<PAGE>   24

         12.7 EMPLOYEES OF SELLER. Purchaser agrees to offer the three (3) full
time employees of the Seller, other than Stiegman, "at-will" employment
positions at their current salaries and with such other terms and conditions as
Purchaser shall determine in its discretion. Purchaser further agrees to give
such employees, and Stiegman, credit for any vacation, sick and personal days
which such persons had accrued with Seller, but which remained unused, all as of
the date of such persons' last day of employment with Seller.

         12.8 LEASE OF REAL PROPERTY BY STIEGMAN. Stiegman currently leases the
real property located at 7300 Huron River Drive, Dexter, Michigan 48130.
Stiegman agrees to allow Purchaser to use this space following the Closing. In
return, Purchaser agrees to reimburse Stiegman personally each month for the
entire amount of the rent due monthly under the lease, for as long as Purchaser
desires to use the space. Stiegman is under no obligation to renew or extend the
lease once the lease term has expired.

         12.8 WAIVER. The waiver by any party of any breach of any provision
hereof shall not operate or be construed as a waiver of any subsequent or
similar breach.

         12.9 AMENDMENT. This Agreement may only be amended by written
agreement executed by the parties hereto, or their respective successor or
assigns.

         12.10 FURTHER ASSURANCES. From time to time after the Closing Date, not
to exceed twelve (12) months, at Purchaser's request and without further
consideration, Seller shall execute and deliver or cause to be executed and
delivered such further instruments of conveyance, assignment and transfer and
shall take such other action as Purchaser may reasonably request in order more
effectively to convey, transfer, reduce to possession or record title to any of
the Assets purchased pursuant hereto. Upon the request of Purchaser, Seller will
cooperate and will use its best efforts to have the officers, directors and
other employees of Seller cooperate with Purchaser on or after the Closing Date
by furnishing information, evidence, testimony and other assistance in
connection with any actions, proceedings, arrangements or disputes involving
Purchaser and which are based upon contracts, leases, arrangements or acts of
Seller which were in effect or occurred on or prior to the Closing Date.

         12.11 ASSIGNMENT. No party to this Agreement may assign his, her or its
rights or duties under this Agreement.

         12.12 COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original and all of which
together shall be considered one and the same agreement.

                                       24
<PAGE>   25

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
fully executed as of the day and year first written above.

                                       SELLER:

                                       BIO PHOTONICS CORPORATION,
                                       a Michigan corporation

                                       By: [sig]
                                          ---------------------------------
                                       Its: President
                                          ---------------------------------

                                       STIEGMAN

                                        /s/ Jeff Stiegman
                                       ------------------------------------
                                       Jeff Stiegman

                                       PURCHASER:

                                       B.I. SYSTEMS CORPORATION d/b/a
                                       BIO IMAGE, a Delaware corporation

                                       By: /s/ Jeff Williams
                                          ---------------------------------
                                              Jeff Williams, President

                                       25

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