Document:

EX-10.1

EXHIBIT 10.1

FIFTH AMENDMENT TO NOTE AND SECURITY AGREEMENT

THIS FIFTH AMENDMENT (THE “FIFTH AMENDMENT”) DATED JULY 27, 2015 TO THE NOTE AND SECURITY
AGREEMENT (THE “AGREEMENT”) DATED AS OF MARCH 31, 2010, AND AS AMENDED ON MARCH 14, 2011 (THE
“FIRST AMENDMENT”), JULY 29, 2011 (THE “SECOND AMENDMENT”), MAY 30, 2012 (THE “THIRD AMENDMENT”),
AND APRIL 18, 2013 (THE “FOURTH AMENDMENT”) AMONG NON-INVASIVE MONITORING SYSTEMS, INC. (THE
“BORROWER”) AND FROST GAMMA INVESTMENTS TRUST (“FROST GAMMA”) AND HSU GAMMA INVESTMNETS, L.P. (“HSU
GAMMA” AND, TOGETHER WITH FROST GAMMA, “LENDER”). THE AGREEMENT, ALONG WITH THE FIRST AMENDMENT,
SECOND AMENDMENT, THIRD AMENDMENT, FOURTH AMENDMENT, AND FIFTH AMENDMENT, SHALL BE REFERRED TO
HEREIN AS THE AMENDED AGREEMENT.

RECITALS

WHEREAS, Borrower and Lender (collectively, the “Parties”) are parties to the Agreement which
became effective on March 31, 2010 and which was amended by the First Amendment on March 14, 2011,
by the Second Amendment on July 29, 2011, by the Third Amendment on May 30, 2012, and by the Fourth
Amendment on April 13, 2015; and

WHEREAS, the Borrower and Lender entered into the Fourth Amendment which extended the Maturity
Date (as originally defined in the Agreement) until July 31, 2015, and

WHEREAS, the Borrower and Lender which to extend the Maturity Date from July 31, 2013 until
July 31, 2017, and

NOW THEREFORE, in consideration of the mutual covenants and promises contained in the
Agreement and this Fifth Amendment and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Borrower and Lender agree as follows:

AMENDMENT

1. Section 3 of the Amended Agreement is hereby amended and restated in its entirety as
follows:

Payments of Obligations, including Principal and Interest. The
principal amount of the Loan evidenced hereby, together with any accrued and unpaid
interest, and any and all the Obligations, including unpaid costs, fees and expenses
accrued, such as Lender’s Expenses, shall be due and payable in full on July 31,
2017 (the “Maturity Date”).

2. Governing Law. This Fifth Amendment shall be governed by the laws of the State of Florida
without regard to its conflict of laws rules or principles.

3. Amendments. Except as expressly amended hereby, the Agreement, the First Amendment, Second
Amendment, Third Amendment, and Fourth Amendment shall remain unmodified and in full force and
effect.

4. Entire Agreement. This Fifth Amendment and the Amended Agreement and any schedules or
exhibits attached to the Agreement constitute the entire agreement of the Parties with respect to
the subject matter hereof and supersede all prior understandings and writings between the Parties
relating thereto.

5. Interpretation. Any capitalized terms used in this Fifth Amendment but not otherwise
defined shall have the meaning provided in the Agreement.

6. Counterparts. This Fifth Amendment may be executed manually, electronically in Adobe® PDF
file format, or by facsimile by the Parties, in any number of counterparts, each of which shall be
considered one and the same amendment and shall become effective when a counterpart hereof shall
have been signed by each of the Parties and delivered to the other Party.

IN WITNESS WHEREOF, Borrower has duly executed this Fifth Amendment to the Note and Security
Note as of the day and year first above written.

	 	 	 
	 	 	NON-INVASIVE MONITORING SYSTEMS, INC.
	
 
	 	By: /s/ James J. Martin
	
 
	 	 
	
 
	 	Name: James J. Martin

Title: Chief Financial Officer
	Agreed and Accepted:

	 	

	FROST GAMMA INVESTMENTS TRUST

	 	

	By: /s/ Philip Frost

	 	

	 

	 	

	Name: Phillip Frost, M.D.

Title: Trustee

	 	

	HSU GAMMA INVESTMENTS, L.P.

	 	

	By: /s/ Jane H. Hsiao

	 	

	 

	 	

	Name: Jane H. Hsiao, Ph.D.

Title: General PartnerEX-10.2

EXHIBIT 10.2

SECOND AMENDMENT TO PROMISSORY NOTE

THIS SECOND AMENDMENT (THE “SECOND AMENDMENT”) DATED JULY 27, 2015, SHALL AMEND THE PROMISSORY
NOTE (THE “NOTE”) DATED AS OF SEPTEMBER 12, 2011 AND AMENDED JULY 31, 2013 (THE “FIRST AMENDMENT”)
AMONG NON-INVASIVE MONITORING SYSTEMS, INC. (THE “MAKER”) AND MARIE WOLF (THE “PAYEE”) AS NOTED
BELOW. THE NOTE, THE FIRST AMENDMENT, AND SECOND AMENDMENT SHALL BE REFERRED TO AS THE AMENDED
NOTE.

RECITALS

WHEREAS, Maker and Payee (collectively, the “Parties”) are parties to the Note which became
effective on September 12, 2011;

WHEREAS, on July 31, 2013, the Parties amended the Note to extend the Maturity Date from
September 12, 2014 until July 31, 2015; and

WHEREAS, the Parties wish to extend the Maturity Date from July 31, 2015 to July 31, 2017.

NOW THEREFORE, in consideration of the mutual covenants and promises contained in the Note and
this Second Amendment and other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the Parties agree as follows:

AMENDMENT

	 	1.	 	Section 1 of the Note is hereby amended and restated in its entirety as
follows:

The principal amount of the loan evidenced hereby, together with any accrued and
unpaid interest, and any and all unpaid costs, fees and expenses accrued, shall be
due and payable on July 31, 2017 (the “Maturity Date”).

2. Governing Law. This Second Amendment shall be governed by the laws of the State of Florida
without regard to its conflict of laws rules or principles.

3. Amendments. Except as expressly amended hereby, the Note shall remain unmodified and in
full force and effect.

4. Entire Agreement. This Second Amendment and the Note constitute the entire agreement of
the Parties with respect to the subject matter hereof and supersede all prior understandings and
writings between the Parties relating thereto.

5. Interpretation. Any capitalized terms used in this Second Amendment but not otherwise
defined shall have the meaning provided in the Note.

6. Counterparts. This Second Amendment may be executed manually, electronically in Adobe® PDF
file format, or by facsimile by the Parties, in any number of counterparts, each of which shall be
considered one and the same amendment and shall become effective when a counterpart hereof shall
have been signed by each of the Parties and delivered to the other Party.

IN WITNESS WHEREOF, Borrower has duly executed this Second Amendment to the Note and Security
Note as of the 27th day of July, 2015.

	 	 	 
	 	 	NON-INVASIVE MONITORING SYSTEMS, INC.
	
 
	 	By: /s/ James J. Martin
	
 
	 	 
	
 
	 	Name: James J. Martin

Title: Chief Financial Officer
	Agreed and Accepted:

	 	

	By: /s/       Marie Wolf—

	 	

	 

	 	

	Name: MARIE WOLFEX-10.3

EXHIBIT 10.3

SECOND AMENDMENT TO PROMISSORY NOTE

THIS SECOND AMENDMENT (THE “SECOND AMENDMENT”) DATED JULY 27, 2015, SHALL AMEND THE PROMISSORY
NOTE (THE “NOTE”) DATED AS OF SEPTEMBER 12, 2011 AND AMENDED ON JULY 31, 2013 (“THE FIRST
AMENDMENT”) AMONG NON-INVASIVE MONITORING SYSTEMS, INC. (THE “MAKER”) AND FROST GAMMA INVESTMENTS
TRUST (THE “PAYEE”) AS NOTED BELOW. THE NOTE, THE FIRST AMENDMENT, AND THE SECOND AMENDMENT SHALL
BE REFERRED TO AS THE AMENDED NOTE.

RECITALS

WHEREAS, Maker and Payee (collectively, the “Parties”) are parties to the Note which became
effective on September 12, 2011;

WHEREAS, on July 31, 2013, the Parties amended the Note to extend the Maturity Date from
September 12, 2014 until July 31, 2015; and

WHEREAS, the Parties wish to extend the Maturity Date from July 31, 2015 to July 31, 2017.

NOW THEREFORE, in consideration of the mutual covenants and promises contained in the Note and
this Second Amendment and other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the Parties agree as follows:

AMENDMENT

	 	1.	 	Section 1 of the Note is hereby amended and restated in its entirety as
follows:

The principal amount of the loan evidenced hereby, together with any accrued and
unpaid interest, and any and all unpaid costs, fees and expenses accrued, shall be
due and payable on July 31, 2017 (the “Maturity Date”).

2. Governing Law. This Second Amendment shall be governed by the laws of the State of Florida
without regard to its conflict of laws rules or principles.

3. Amendments. Except as expressly amended hereby, the Note shall remain unmodified and in
full force and effect.

4. Entire Agreement. This Second Amendment and the Amended Note constitute the entire
agreement of the Parties with respect to the subject matter hereof and supersede all prior
understandings and writings between the Parties relating thereto.

5. Interpretation. Any capitalized terms used in this Second Amendment but not otherwise
defined shall have the meaning provided in the Note.

6. Counterparts. This Second Amendment may be executed manually, electronically in Adobe® PDF
file format, or by facsimile by the Parties, in any number of counterparts, each of which shall be
considered one and the same amendment and shall become effective when a counterpart hereof shall
have been signed by each of the Parties and delivered to the other Party.

IN WITNESS WHEREOF, Borrower has duly executed this Second Amendment to the Note and Security
Note as of the 27th day of July, 2015.

	 	 	 
	 	 	NON-INVASIVE MONITORING SYSTEMS, INC.
	
 
	 	By: /s/ James J. Martin
	
 
	 	 
	
 
	 	Name: James J. Martin

Title: Chief Financial Officer
	Agreed and Accepted:

	 	

	FROST GAMMA INVESTMENTS TRUST

	 	

	By: /s/ Phillip Frost

	 	

	 

	 	

	Name: Phillip Frost, M.D.

Title: TrusteeEX-10.4

EXHIBIT 10.4

SECOND AMENDMENT TO PROMISSORY NOTE

THIS SECOND AMENDMENT (THE “SECOND AMENDMENT”) DATED JULY 27, 2015, SHALL AMEND THE PROMISSORY
NOTE (THE “NOTE”) DATED AS OF MAY 30, 2012 AND AMENDED ON JULY 31, 2013 (“THE FIRST AMENDMENT”)
AMONG NON-INVASIVE MONITORING SYSTEMS, INC. (THE “MAKER”) AND HSU GAMMA INVESTMENTS TRUST, L.P.
(THE “PAYEE”) AS NOTED BELOW. THE NOTE, THE FIRST AMENDMENT, AND THE SECOND AMENDMENT SHALL BE
REFERRED TO AS THE AMENDED NOTE.

RECITALS

WHEREAS, Maker and Payee (collectively, the “Parties”) are parties to the Note which became
effective on May 30, 2012;

WHEREAS, on July 31, 2013, the Parties amended the Note to extend the Maturity Date from
September 12, 2014 until July 31, 2015; and

WHEREAS, the Parties wish to extend the Maturity Date from July 31, 2015 to July 31, 2017.

NOW THEREFORE, in consideration of the mutual covenants and promises contained in the Note and
this Second Amendment and other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the Parties agree as follows:

AMENDMENT

	 	1.	 	Section 1 of the Note is hereby amended and restated in its entirety as
follows:

The principal amount of the loan evidenced hereby, together with any accrued and
unpaid interest, and any and all unpaid costs, fees and expenses accrued, shall be
due and payable on July 31, 2017 (the “Maturity Date”).

2. Governing Law. This Second Amendment shall be governed by the laws of the State of Florida
without regard to its conflict of laws rules or principles.

3. Amendments. Except as expressly amended hereby, the Note shall remain unmodified and in
full force and effect.

4. Entire Agreement. This Second Amendment and the Note constitute the entire agreement of
the Parties with respect to the subject matter hereof and supersede all prior understandings and
writings between the Parties relating thereto.

5. Interpretation. Any capitalized terms used in this Second Amendment but not otherwise
defined shall have the meaning provided in the Note.

6. Counterparts. This Second Amendment may be executed manually, electronically in Adobe® PDF
file format, or by facsimile by the Parties, in any number of counterparts, each of which shall be
considered one and the same amendment and shall become effective when a counterpart hereof shall
have been signed by each of the Parties and delivered to the other Party.

IN WITNESS WHEREOF, Borrower has duly executed this Second Amendment to the Note and Security
Note as of the 27th day of July, 2015.

	 	 	 
	 	 	NON-INVASIVE MONITORING SYSTEMS, INC.
	
 
	 	By: /s/ James J. Martin
	
 
	 	 
	
 
	 	Name: James J. Martin

Title: Chief Financial Officer
	Agreed and Accepted:

	 	

	HSU GAMMA INVESTMENTS, L.P.

	 	

	By: /s/ Jane H. Hsiao

	 	

	 

	 	

	Name: Jane H. Hsiao, Ph.D.

Title: General Partner

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