Document:

Third Amendment of Research and Commercial Option License Agreement

 Exhibit 10.40 
 THIRD AMENDMENT OF 
 THE RESEARCH AND COMMERCIAL
LICENSE OPTION AGREEMENT 
 This THIRD AMENDMENT OF THE
RESEARCH AND COMMERCIAL LICENSE OPTION AGREEMENT (this “Third Amendment”) is made and effective as of February 28,
2009 (the “Third Amendment Effective Date”) by and between SANGAMO BIOSCIENCES, INC., a Delaware corporation having its principal place of
business at Point Richmond Tech Center, 501 Canal Boulevard, Suite A100, Richmond, California 94804 (“Sangamo”), and DOW AGROSCIENCES LLC, a Delaware limited liability company
having its principal place of business at 9330 Zionsville Road, Indianapolis, Indiana 46268 (“DAS”) (each of Sangamo and DAS being a “Party,” and collectively, the “Parties”). 
 WHEREAS, Sangamo and DAS are parties to certain Research and Commercial License Option Agreement, dated as of October 1, 2005
(as previously amended, the “Agreement”); 
 WHEREAS, pursuant to Section 2.6(b) of the Agreement,
the Parties may expand the licenses granted by Sangamo to DAS in Section 2.1 of the Agreement to include sublicenses under intellectual property licensed to Sangamo after the Effective Date of the Agreement; 
 WHEREAS, on June 5, 2007, Sangamo entered into a License Agreement (the “Utah Agreement”) with the University
of Utah Research Foundation (“Utah”), pursuant to which Sangamo received a license under certain intellectual property (the “Utah IP”); and 
 WHEREAS, Sangamo and DAS now desire to amend the Agreement as set forth below to include a sublicense under intellectual property
licensed to Sangamo pursuant to the Utah Agreement. 
 NOW THEREFORE, in consideration of the mutual promises and
agreements set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows: 
 1. The Parties hereby agree that the Utah Agreement is, as of the Third Amendment Effective Date, deemed to be a Third Party License in accordance with Section 2.6(b) of the Agreement. DAS hereby
agrees and acknowledges that its sublicense to the Utah IP is subject to the terms and conditions of the Utah Agreement and that such terms and conditions (with the exception of any financial provisions) are hereby incorporated by reference into the
Agreement. 
 2. DAS shall provide Sangamo, within twenty (20) days of execution thereof, with a copy of each agreement pursuant to which
DAS grants a sublicense of the Utah IP and each document amending or and terminating such an agreement. Sangamo shall be permitted to provide Utah with copies of such agreements and documents in accordance with Section 4.5 of the Utah
Agreement. 
  

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 3. Notwithstanding the payments that DAS would otherwise have been responsible for pursuant to Sections
8.11(b), (c), (d) and (e) of the Agreement solely with respect to the Utah Agreement, DAS shall only be responsible for paying the following payments owed to Utah under the Utah Agreement: 
 (a) the annual sublicense fees due pursuant to Section 4.3(a)(ii) or 4.3(b)(ii) of the Utah Agreement, whichever is applicable, for
DAS’ sublicense to the Utah IP; 
 (b) the sublicense fee due pursuant to Section 4.3(a)(i) or 4.3(b)(i) of the Utah
Agreement, whichever is applicable, for each sublicense granted by DAS to the Utah IP; 
 (c) the annual sublicense fees due
pursuant to Section 4.3(a)(ii) or 4.3(b)(ii) of the Utah Agreement, whichever is applicable, for each sublicense granted by DAS to the Utah IP; and 
 (d) the costs and legal fees owed by Sangamo pursuant to Section 10.2 of the Utah Agreement for the preparation, prosecution and maintenance of Field Specific Sangamo Patents that are licensed under
the Utah Agreement; provided that Sangamo provides DAS with an invoice therefor promptly after it receives the corresponding invoice from Utah. 
 DAS shall pay such amounts to Sangamo, and provide Sangamo with any corresponding reports, at least ten (10) days in advance of the applicable due date. Provided it receives such items in a timely manner, Sangamo shall pay such amounts
to, and file such reports with, Utah on or before the applicable due date. 
 4. This Third Amendment amends the terms of the Agreement as
expressly provided above, and the Agreement, as so amended and including all of its other terms and provisions that are not amended, remains in full force and effect. Capitalized terms used but not defined herein shall have the meanings set forth in
the Agreement. The validity, performance, construction, and effect of this Third Amendment shall be governed by and construed under the substantive laws of the State of Delaware, as applied to agreements executed and performed entirely in the State
of California by residents of the State of Delaware, without regard to conflicts of law rules that would cause the application of the laws of another jurisdiction. This Third Amendment may be executed in counterparts, all of which taken together
shall be regarded as one and the same instrument. 
 In Witness Whereof, the Parties have executed this Third Amendment
in duplicate originals by their proper officers as of the Third Amendment Effective Date. 
  

									
	SANGAMO BIOSCIENCES, INC.	 		 	DOW AGROSCIENCES LLC
					
	By:	 	 /s/ David G. Ichikawa
	 		 	By:	 	 /s/ Kay Kuenker

	Name:	 	 David G. Ichikawa
	 		 	Name:	 	 Kay Kuenker

	Title:	 	 SVP Business Development
	 		 	Title:	 	 VP of New Business Platform

  

 2First Amendment to the Research, Development and Commercialization Agreement

 Exhibit 10.44 
 NOTE: Portions of this Exhibit are the subject of a Confidential Treatment Request by the Registrant to the Securities and Exchange Commission (the “Commission”). Such portions have been
redacted and are marked with a “[***]” in the place of the redacted language. The redacted information has been filed separately with the Commission. 
 FIRST AMENDMENT TO 
RESEARCH, DEVELOPMENT AND COMMERCIALIZATION AGREEMENT BETWEEN SANGAMO BIOSCIENCES, INC. (“SANGAMO”) AND JUVENILE DIABETES RESEARCH FOUNDATION INTERNATIONAL
(“JDRF”) 
 This First Amendment (this “First Amendment”) to the Agreement of
October 24, 2006 is made as of this 8th day of
January 2010 (the “First Amendment Effective Date”) by and between Sangamo and JDRF. Capitalized terms used but not defined herein shall have the definition provided in this Agreement. 
 WHEREAS, the Parties entered into the Agreement; and 
 WHEREAS, the Parties now desire to amend the Agreement so that JDRF may support Sangamo’s SB-509-901 clinical trial which is entitled “A Phase 2b Repeat Dosing Clinical Trial of SB-509 in
Subjects with Moderately Severe Diabetic Neuropathy”. 
 NOW THEREFORE, in consideration of the foregoing, the receipt and
sufficiency of which is hereby acknowledged, the Parties agree as follows: 
 1. Confirmation of Terms.

 Except as provided in this First Amendment, the Agreement shall remain in full force and effect. 
 2. Acknowledgement. 
 The Parties hereby acknowledge that, prior to the First Amendment Effective Date, Sangamo fulfilled its obligations under the Agreement to perform the Research Plan as described in Exhibit A and to
achieve the Milestones set forth in Exhibit B as it existed prior to the First

  

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Amendment Effective Date, and JDRF fulfilled its obligations under the Agreement to pay to Sangamo the amounts set forth in Exhibit B as it existed prior to the First Amendment Effective
Date. 
 3. Amendment to Agreement. 
 The following amendments shall be made to the Agreement: 
 (a) The term
“Award” as defined in Section 1.5 of the Agreement shall be amended to substitute “Six Million Dollars ($6,000,000”) ” in lieu of “Three Million Dollars ($3,000,000)” previously specified therein; 

(b) The definition of “Research Plan” as set forth in Section 1.54 of the Agreement shall be replaced with the following:
“‘Research Plan’ means (a) the written protocol for Sangamo’s Phase II Repeat Dosing Clinical Trial of SB-509, that shall be attached to this Agreement as Exhibit A upon approval by the FDA, which
protocol was based on the Application, includes the JDRF Studies, and has been accepted by the FDA, as modified from time to time by Sangamo in consultation with the FDA and in accordance with Section 2.4 and (b) the written protocol for
Sangamo’s SB-509-901 clinical trial that is attached to the First Amendment as Exhibit C, which Exhibit will be updated to reflect any amendments to such protocol that are agreed upon by Sangamo and the FDA.”

 (c) Section 3.1.2(a) shall be amended by increasing “Three Million Dollars ($3,000,000)” to “Six Million
Dollars ($6,000,000)”; 
 (d) Section 7.7 (Insurance) of the Agreement is hereby deleted in its entirety and is
replaced with the following provision: 
  

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 Insurance. Sangamo shall maintain at its own expense, with a reputable insurance carrier reasonably
acceptable to JDRF, coverage for Sangamo, its Affiliates, and their respective employees written on a per occurrence basis commensurate with a reasonable assessment of the risks associated with the research efforts being conducted by Sangamo, the
following policies: 
 (a) Comprehensive general liability insurance for claims relating to the performance and lack of performance of
Sangamo’s obligations under this Agreement; 
 (b) Comprehensive general liability insurance for claims for damages, including, damages as
a result of bodily injury (including death) and damages to property, arising out of acts or omissions of a Sangamo Party; 
 (c) Products
liability insurance for claims for damages, including, damages as a result of bodily injury (including death) and damages to property, arising out of the acts or omissions of a Sangamo Party; and 
 (d) Clinical trials liability insurance for damages, including, damages as a result of bodily injury (including death) and damages to property, arising out
of any clinical trials conducted by Sangamo in connection with its obligations under the Agreement, or arising out of the acts or omissions of a Sangamo Party. This insurance shall specifically include coverage for obligations and liabilities of
Sangamo under any clinical trial agreement or protocol that is a part of clinical trials conducted by Sangamo under the Agreement and for liability arising as a result of allegations of the insufficiency or other defects in the informed consent
provided to participants in the clinical trials. 
  

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 All insurance policies required hereunder shall name JDRF as an additional insured, be specifically endorsed
to cover Sangamo’s indemnification obligations under this Article VII and be written with coverage limits approved by JDRF. Maintenance of such insurance coverage will not relieve Sangamo of any responsibility under this Agreement for
damage in excess of insurance limits or otherwise. On or prior to the First Amendment Effective Date, Sangamo shall provide JDRF with an insurance certificate from the insurer(s) evidencing each insurance coverage and the insurer’s agreement to
notify JDRF at least sixty (60) days in advance of any cancellation or material modification of such insurance coverage. At its request, JDRF may review Sangamo’s insurance coverage with relevant Sangamo officials from time to time.

 In the event that the Interruption License becomes effective pursuant to Section 9.5, JDRF shall comply with the
foregoing insurance requirements and shall maintain such insurance for as long as necessary to cover any claims that may arise from JDRF’s activities during the effectiveness of the Interruption License. 
 (e) Section 11.10 shall be amended to replace the notice address for JDRF with the following: 
 Richard Insel, MD 
 Chief Scientific Officer 
 Executive Vice President, Research

 Juvenile Diabetes Research Foundation International 
 26 Broadway, 14th Floor 
 New York, NY 10004 
 Tel.: 212-479-7604 
 Email: rinsel@jdrf.org 
 (f) Exhibit B shall be replaced with the Exhibit B attached to this First Amendment; and 
 (g) Exhibit C attached to this First Amendment shall be added to the Agreement. 
 [Signatures on next page] 
  

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 IN WITNESS WHEREOF, the undersigned have executed this First Amendment as of the First
Amendment Effective Date. 
  

			
	Sangamo BioSciences, Inc.
		
	By:	 	/s/ Edward O. Lanphier
		 	 
	Name:	 	Edward O. Lanphier
	Title:	 	President and Chief Executive Officer
	
	Juvenile Diabetes Research Foundation International
		
	By:	 	/s/ Alan J. Lewis
		 	 
	Name:	 	Alan J. Lewis, Ph.D.,
	Title:	 	President and Chief Executive Officer

  

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 EXHIBIT B 
 RESEARCH FUNDING AND MILESTONES 
 I. Payment Schedule
for Research Funding: Up to an aggregate amount of Six Million Dollars ($6,000,000), payable as follows: 
  

			
	 Milestones

	  	Payment Amount ($)
	1. Upon the Effective Date, if FDA acceptance of Phase 2 plan (102 patients in two treatment
groups) has occurred; or upon FDA acceptance of such Phase 2 plan, if such acceptance has not yet occurred as of the Effective Date	  	$[***]
	2. Enrollment of the first Qualified Subject	  	$[***]
	3. Enrollment of the 25th Qualified Subject	  	$[***]
	4. Enrollment of the 50th Qualified Subject	  	$[***]
	5. Enrollment of the 100th Qualified Subject	  	$[***]
	6. Receipt by JDRF of the final report of the Primary Statistical Analysis	  	$[***]
	7. Initiation of patient screening for SB-509-901	  	$[***]
	8. First patient for SB-509-901 randomized by assignment of randomization number	  	$[***]
	9. 76th patient, or 50% of the then planned number of patients for SB-509-901, whichever occurs
first, randomized by assignment of randomization number	  	$[***]
	10. 150th patient, or the last planned patient for SB-590-901, whichever occurs first,
randomized by assignment of randomization number	  	$[***]
	11. Submission to JDRF of day 180 data analysis for SB-509-901	  	$[***]
	12. Submission to JDRF of day 360 data analysis for SB-509-901	  	$[***]
	13. Submission to JDRF of draft clinical study report for
SB-509-901	  	$[***]

  

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 *** CONFIDENTIAL PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION 

 EXHIBIT C 
 RESEARCH PLAN FOR FIRST AMENDMENT 
  

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 [***] 
  

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 *** CONFIDENTIAL PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION

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