Document:

Employment Agreement with amendment dated as of June 15, 2007 with Tamas Vagany

 Exhibit 10.1 
 EMPLOYMENT CONTRACT 
 THIS CONTRACT IS MADE BETWEEN 
 Invitel Távközlési Szolgáltató Zrt. 
 Registered address: 2040 Budaörs, Puskás Tivadar utca 8-10. 
 Tax no.: 
 hereinafter referred to as the “Employer” 
 AND 
 Name: Tamás Vágány 
 Place and date of birth: 
 Mother’s name: 
 Address: 
 Healthcare Identification No.
(TAJ): 
 Tax No.: 
 hereinafter
referred to as the “Employee” 
  

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 NOW THE EMPLOYER AND THE EMPLOYEE ACKNOWLEDGE AND AGREE AS FOLLOWS: 
  

	I.	EMPLOYMENT 

  

	1.1.	The Employer shall employ the Employee in an employment relationship in accordance with the legal framework established by Act XXII of 1992 on the Labor Code (hereinafter referred
to as the “Labor Code”), the relevant and applicable laws and regulations of the Republic of Hungary regarding employment, the applicable internal regulations of the Employer and the provisions of this Employment Agreement.

  

	1.2.	The employer’s rights over the Employee may be exercised by the person or persons who is or are authorized to exercise the employer’s rights by Management (in Hungarian:
“Igazgatóság”). 

  

	II.	SCOPE OF WORK 

  

	2.1.	The title of the Employee is: Sales Deputy Chief Executive Officer (in Hungarian: “Értékesítési vezérigazgató helyettes”).

  

	2.2.	The responsibilities and duties of the Employee are to be described in the scope of work attachment to this Employment Contract that is to be issued at a later point in time.

  

	2.3.	The Employee shall spend his working hours performing, and use his expertise to carry out, the assignments and duties arising from the scope of his work, and the Employee shall take
all steps necessary in order to ensure the successful and profitable operation of the company. 

  

	III.	DURATION OF EMPLOYMENT 

  

	3.1.	The Employment Contract was executed on June 15, 2007, and is valid for an indefinite period. 

 As to the continuity of the employment of the Employee, the provisions of Section 9.4 shall be applicable. 
  

	IV.	REMUNERATION 

  

	4.1.	The Employee shall be entitled to a monthly salary as consideration for performing his duties. The amount of the basic monthly salary shall be: 

 HUF 2,250,000, that is, two million, two hundred and fifty thousand Forints. 
  

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 (With respect to the period between May 1, 2007 and the date of the execution of this Employment
Contract, the difference between the above salary and the salary paid by the previous employer of the Employee shall be transferred to the Employee during the month in which the Employee starts working at the Company.) 
 The basic salary includes the fee for the Employee to perform work related to the scope of work of the Employee, including the performance of such work in
overtime. In respect of the performance of work outside of regular working (standby, overtime, and work performed on a resting day or on a bank holiday), the Employee is not entitled to extra remuneration. 
 The basic salary of the Employee shall be reviewed by the Employer each time raises are regularly given by the company, or independently from such raise,
on an annual basis, and the Employer shall make a decision as to a salary raise for the Employee based upon the circumstances then existing (especially the efficiency of the work of the Employee and the inflation rate). 
  

	4.2.	The Employer shall pay the basic salary to the Employee, after having deducted taxes, by way of a transfer to the bank account of the Employee on the last working day of the month
or on the first working day of the subsequent month, but no later than set out in the provisions of the Labor Code. 

  

	4.3.	The Employer shall pay a premium to the Employee above the amount of the basic salary, if certain goals are reached. The Employer and the Employee shall reach an agreement no later
than the end of the first quarter of a given year specifying the requirements for the awarding of a premium in such given year,. 

  

	 	a.)	The basis of the premium shall be the amount of the basic salary paid to the Employee in the given year. 

 (Given year: refers to the calendar year or business year in which the mutually agreed goals to be completed for the payment of the premium are to be
completed.) 
  

	 	b.)	The amount of the premium to be paid to the Employee is to be subsequently determined by the supervisor of the Employee for the given year during the course of an evaluation of the
Employee. The maximum amount of the premium shall be 35%, and the Employee is entitled to such a premium on a pro rata basis from May 1, 2007. As a result of the evaluation, the amount of the premium payable may be lower than the aforementioned
maximum, or no premium may be paid. 

  

	V.	FURTHER BENEFITS 

  

	5.1.	The Employee acknowledges that whether the benefits referred to in this Section V are actually provided to the Employee, as well as the amount of such benefits, depends upon the
internal regulations of the Employer. Therefore, if due to a change in these internal regulations, these benefits cease to exist or the amount of these benefits changes, this does not constitute a breach of this Employment Contract on the part of
the Employer; in such an event the contents of this Employment Contract – without the need of an amendment thereof – change in accordance with the change in the internal regulations. 

  

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	5.2.	The Employer shall provide the Employee with a mobile phone so the Employee can perform his work duties. 

  

	5.3.	The Employer shall provide the Employee with a vehicle, with the model of the vehicle to be at the discretion of the Employer, for personal and official use, during the term of the
employment, and in the case of the termination of the employment, until the last working day of the Employee, with the rules and regulations regarding the use of the vehicle being as set out in the applicable Vehicle Regulations of the Employer.

  

	5.4.	The Employer shall reimburse the Employee for the out-of-pocket costs and expenses that arise in connection for the performance of his work duties, including the costs of business
entertainment and travel, provided that the Employee informs the Employer of such costs and expenses, and provided that the Employee provides the relevant organizational unit with receipts showing the date, amount and description of the costs and
expenses arising, upon the approval of the Employer. 

  

	5.5.	The Employer shall take out a life insurance and an accidental injury insurance policy benefiting the Employee, with the same terms and conditions as the insurance policies of the
other management personnel of the company group. The premium for the insurance policy shall be fully paid by the Employer. If the employment is terminated, regardless of the reason for the termination, the Employee shall decide whether to maintain
the insurance policy, at his own discretion, but the Employer shall no longer be obligated to pay the insurance premium. 

  

	VI.	PLACE OF WORK 

  

	6.1.	The place of work is the registered seat, sites and branch offices of the Employer. 

  

	6.2.	Should the Employer deem it necessary for the Employee to properly perform his work duties, the Employee may be required to work at the registered seat, site or branch office of
another member of the company group to which the Employer belongs or which controls the company. In this case, the Employer shall reimburse the Employee for any costs and expenses arising from his compliance with this requirement (especially
accommodation and travel costs). 

 The Parties agree that that the maximum duration that the Employer may request the Employee
to perform his duties at a site other than the registered seat, sites and branch offices of the Employer is two months out of each calendar year. Should such period be exceeded, the Employee can be required to perform his work duties at a place
other than the place defined in Section 6.1, based upon a separate agreement. 
  

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	VII.	WORKING HOURS, VACATION/LEAVE 

  

	7.1.	The Employee shall perform his work duties with a flexible schedule that is suitable for the performance of his work duties. 

  

	7.2.	The Employee shall be entitled to vacation time, as set out in the provisions of the Labor Code relating to paid vacation. If the employment commences or is terminated during the
calendar year, the Employee is entitled to vacation days on a pro rata basis. 

  

	VIII.	CONFLICT OF INTEREST, ETHICAL BEHAVIOUR, CONFIDENTIALITY 

  

	8.1.	Unless the Employer provides its prior written consent, the Employee shall not establish another employment relationship or other legal relationship that is aimed at the performance
of work. This restriction does not apply to any legal relationship that was established with respect to the performance of scientific and educational activities. 

  

	8.2.	Unless the Employer provides its prior written consent, the Employee may not hold an executive officer position at a company that is not within the company group (managing director,
member of management, member entitled to perform business management), and may not accept membership in a supervisory board of such a company. 

  

	8.3.	The Employee shall inform the Employer of any employment involving any legal relationship that is of the kind referred to in Section 8.1 or of any position that is of the kind
referred to in Section 8.2 prior to the commencement thereof, but, at the latest, within 15 days of commencement thereof. As to the approval of such legal relationships, the Employer shall either approve or not approve the legal relationship in
question prior to the commencement of such legal relationship or, if the Employee does not inform the Employer of such legal relationship until after its commencement, within 30 days of the Employer being so informed. The Employer shall not
unreasonably deny such approval. Should the Employer refuse to provide such approval, the Employee shall terminate such legal relationship within 30 days, and provide evidence of such termination. Should the Employer be of the opinion that holding a
position of the kind referred to in Section 8.2 would be a conflict of interest, the Employee shall vacate such position within 90 days, and the Employee shall provide evidence to the Employer that such position was vacated.

  

	8.4.	The Employee acknowledges that if the Employee breaches any obligation of Sections 8.1, 8.2 or 8.3, the Employer is entitled to terminate this Employment Contract through ordinary
termination, and if the Employer incurs any damages due to such a breach or the Employee does not cease the activities causing the conflict of interest after the Employer so requests, the Employer is entitled to terminate this Employment Contract by
way of extraordinary termination. 

  

	8.5.	 The Employee is obliged to notify the Employer if a close relative of the Employee becomes an employee of or establishes an employment relationship, as a member of
management, as an executive officer or as a member of the supervisory board, with a business entity that is engaged in the same or similar activity as that of the Employer, 

  

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or with a business entity that is in a regular business relationship with the Employer. A close relative, from the point of view of this notification
obligation, is any of the following: a spouse; direct relative; adopted child; step-child; common law child; adoptive parents; step-parents and common law parents; and siblings. 

  

	8.6.	The Employee may not hold any interest – except for those in a public company limited by shares – in another organization that is engaged in the same or similar activity
as that of the Employer, or in a business entity that is in a regular business relationship with the Employer. 

  

	8.7.	The Employee may not conclude a transaction, in his name or for his benefit, which is within the scope of the activities of the Employer. 

  

	8.8.	For the purposes of Sections 8.5., 8.6., 8.7., 8.12., telecommunication (electronic communication) shall be considered to be a similar activity. 

  

	8.9.	The Employee shall comply with an ethical code of conduct while performing his work duties, and within the framework of such ethical code, the Employee shall (a) avoid
developing a business relationship with a business organization in which the Employee has a business interest, in any form, directly or indirectly, (b) not accept gifts that are of a greater value than common hospitality gifts in respect of
negotiations with business partners, (c) not use a relationship with business partners for personal purposes, (d) refrain from providing or promising unlawful favors to any person within the scope of the business and services of the
Employer. Should there be any uncertainty as to what is included in the foregoing list, the Employee shall consult his immediate superior. 

  

	8.10.	While carrying out his work duties, the Employee may have access to confidential information, the passing on of which to third parties may harm the business interests of the
Employer. 

 Therefore, during the term of the employment, and during the three year period after the termination of the
employment, the Employee shall not inform any third party of, and shall not provide any third party with, any information – regardless of the format – that is related to the business relations, transactions, clients, clientele, suppliers,
invoices, business issues, investments or negotiations of the Employer, the company group managed by the Employer, or the company group of which the Employer is a member. 
 The Employee shall also not provide any third party with any information that is classified as confidential, directly or indirectly, or any information that the Employee should have recognized as confidential due to
the scope of the work of the Employee. 
 Further to the above, at the time of the termination of the employment, the Employee shall also be
obliged to hand over any data recording medium holding information that the Employee received during the time of the employment, or which resulted from the employment. 
  

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 The Employee and the Employer hereby agree and acknowledge that until the termination of the employment,
the Employer shall unilaterally declare if this confidentiality obligation is or is not binding upon the Employee. Should the Employer declare that this confidentiality obligation is binding, then, without any further negotiations and declarations,
this agreement with the present contents shall be considered as concluded. As consideration for this confidentiality obligation, the Parties agree that an amount equal to three times the monthly basic salary shall be paid, in one lump sum, to the
Employee by the Employer. 
 Should the Employer declare that the confidentiality obligation is not binding, or fail to make a declaration as
to whether the confidentiality obligation is or is not binding, following the termination of the employment, the confidentiality obligation – and the aforementioned lump sum payment obligation of the Employer – shall cease to exist.

 Should the Employee breach the confidentiality obligation set in this Section, the Employer is entitled to the reimbursement of the
aforementioned lump sum payment made by the Employer, and, in addition to the amount of the lump sum, may request the payment of an amount equal to the lump sum as a general indemnity. 
  

	8.11.	In the case of the termination of the employment for any reason, within the one year period thereafter, the Employee shall not cause any employees of the Employer, or the company
group under the management of the Employer or of which the Employer is a member, to terminate their employment, where such employees, at the time of the termination, were employed by the Employer or by any member of the company group.

  

	8.12.	In the case of the termination of the employment for any reason, within the two year period thereafter, the Employee cannot engage in activities which are in competition with the
activities with the Employer in Hungary, neither directly nor indirectly. Competition activities: any activities that may take place inside or outside of the regulated legal boundaries which may involve the use of the experience and business
relations that the Employee gained while working for the Employer, with regards to the market position, scope of activities and business relations of the Employer, which violate the lawful business interests of the Employer.

 With respect to the above, the following are considered as violating the lawful business interests of the Employer, though
this list is not exclusive: 
 a.) The establishment of an employment or other legal relationship for the purpose of work in a business entity
or other organization that operates or provides services in the same field as the field which represents the principal activity of the Employer (a competitor). 
 b.) The establishment of a membership in a competing company that requires a non-monetary personal contribution. 
 c.) Operations or the provision of services as a private entrepreneur, where such is the same as the principal activity of the Employer. 
  

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 d.) The provision of services to a competing company as a member or an employee of a consulting
organization. 
 The Employee and the Employer hereby agree and acknowledge that until the termination of the employment, the Employer shall
unilaterally declare if this non-competition obligation is or is not binding upon the Employee. Should the Employer declare that this non-competition obligation is binding, then, without any further negotiations and declarations, this agreement with
the present contents shall be considered as concluded. As consideration for this non-competition obligation, the Employer, on the last working day of the Employee, shall pay the Employee the amount set out below. 
 The then average monthly salary: 
  

	 	•	 	 multiplied by six, if this non-competition obligation is valid for is 1 (one) year, 

  

	 	•	 	 multiplied by twelve, if this non-competition obligation is valid for 2 (two) years. 

 Should the Employer declare that this non-competition obligation is not binding, or fail to make a declaration as to whether this non-competition
obligation is or is not binding, following the termination of the employment, this non-competition obligation – and the aforementioned payment obligation of the Employer – shall cease to exist. 
 Should the Employee breach this non-competition obligation set in this Section, the Employer is entitled to the reimbursement of the aforementioned
payment made by the Employer, and, in addition to the amount of the aforementioned payment, may request the payment of an amount equal to the amount of the aforementioned payment as a general indemnity. 
  

	IX.	TERMINATION OF EMPLOYMENT 

  

	9.1.	This Employment Contract may be terminated in accordance with the rules and regulations of the Labor Code. 

  

	9.2.	In the case of the termination of the employment by the Employer by way of ordinary termination, the required notice period of the termination shall be 12 (twelve) months, and in
the case of the termination of the employment by the Employee by way of ordinary termination, the required notice period of the termination shall be 6 (six) months. 

  

	9.3.	At the time of the termination of the employment, on the last working day of the Employee, the Employer shall pay the Employee his salary and other benefits, and the Employer shall
also provide the Employee with documents related to the employment, as set out by law. 

  

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	9.4.	The Employer, in respect of the present employment, agrees to, within the meaning of the labor law, be the successor employer of the Employee with respect to the employment of the
Employee with his former employer, that is, regarding the rights and obligations arising from the former employment, the Employer considers the employment of the Employee with his former employer as having been with the Employer. Name and address of
the former employer: Pantel Kft., 1113 Budapest, Bocskai út 134.-146. 

 This succession, per the applicable labor law,
shall primarily, though not exclusively, be taken into consideration in respect of the length of the notice period and the calculation of the severance payment by the Parties. 
 Based upon the above, the commencement date of the present employment is acknowledged as legally starting on August 9, 1999. 
  

	X.	CLOSING PROVISIONS 

  

	10.1.	The Employer and the Employee hereby acknowledge and agree that during preparation and negotiation of this Employment Contract, the Parties informed each other of all the facts or
circumstances that are significant with respect to this Employment Contract. 

  

	10.2.	This Employment Contract summarizes and contains all the terms and agreements between the Employer and the Employee related to the employment. 

  

	10.3.	This Employment Contract was executed and delivered in two Hungarian language and two English language copies. 

 IN WITNESS whereof this Employment Contract has been executed by the Employer and the Employee, and is intended to be and is hereby delivered on the date written below.

 Budaörs, June 15, 2007 
  

					
	 	 		 	 
	Employer	 		 	Employee

  

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 AMENDMENT AGREEMENT TO THE EMPLOYMENT AGREEMENT 
 CONCLUDED BY AND BETWEEN 
 INVITEL
Távközlési Szolgáltató Zártköruen Muködo Részvénytársaság 
 (registered seat: H-2040 Budaörs, Puskás Tivadar utca 8-10) 
 hereinafter referred to as the Employer

 AND 
 Vágány Tamás

 hereinafter referred to as the Employee 
  

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 The Employer and the Employee hereby declare to make the following amendments to the employment agreement dated
June 15, 2007 (the “Employment Agreement”). 
 Section IV “Remuneration” of the Employment Agreement is hereby supplemented with the
following additional sub-Sections 4.4 and 4.5: 
  

	 	4.4.	In the event of a “Trigger Event” (as defined below) in which the per share consideration, determined on a fully diluted basis, to be received by holders of shares of the
Hungarian Telephone and Cable Corp.’s (“HTCC”) common stock (the “Per Share Consideration”) shall, subject to this Section 4.4, equal at least U.S.$ 14.69 (the “Agreed HTCC Share Price), the Employee shall be
entitled to a bonus (the “Transaction Bonus”) in an amount and subject to the terms set forth on Exhibit A attached hereto. For the avoidance of doubt, the Transaction Bonus shall only be payable with respect to the first Trigger Event to
be completed and shall not be payable for any future Trigger Events. 

 For the purpose of this Section 4.4, “Trigger
Event” shall mean the first to occur of (i) any transaction or series of transactions, including a consolidation or merger of the Employer, where the direct or indirect shareholders of the Employer, immediately prior to such transaction or
series of transactions, would not, immediately after such transaction or series of transactions, beneficially own (as such term is defined in Rule 13d-3 under the U.S. Securities and Exchange Act of 1934), directly or indirectly, shares representing
in the aggregate 50% or more of the combined voting power of the securities of the surviving entity (or its ultimate parent) of such transaction or series of related transactions or (ii) a sale by the Employer of all or substantially all of its
assets (other than to an Affiliate of the Employer). As used in this Section 4.4, “Affiliate” shall mean any individual, partnership, joint venture, corporation, trust, unincorporated organization, government or other entity (each, a
“Person”), which, directly or indirectly, owns more than 50% of the voting securities or partnership or other membership or ownership interests of, or controls, or is owned or controlled by, or is under common control with, the Employer;
for the purpose of this definition, the term “control” as applied to any Person, means the possession, directly or indirectly, of the power to direct or cause the direction of the management of that Person, whether through ownership of
voting securities or otherwise. 
 In the event of any change in the outstanding common stock of HTCC as a result of any stock split,
spin-off, stock dividend, reverse stock split, stock combination or reclassification, recapitalization or merger, or similar event, the Agreed HTCC Share Price shall be adjusted appropriately to take account of such change. 
  

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	 	4.5.	In the event that the Employment Agreement is terminated by the Employer for “Cause” (as defined below) or by the Employee without “Good Reason” (as defined
below) prior to a Trigger Event, the Employee shall not be entitled to any Transaction Bonus. In the event the Employment is terminated by the Employer without Cause or by the Employee for Good Reason prior to a Trigger Event, the Employee shall be
entitled to a pro rata portion of the Transaction Bonus (payable at such time as the Transaction Bonus would be payable pursuant to Section 4.4) calculated as follows: the Transaction Bonus, multiplied by the fraction in which the numerator is
the number of actual days between 27 April 2007 and the date of the termination of the employment of the Employee, and the denominator is the number of days between 27 April 2007 and the date of the Trigger Event. 

A termination of the Employment Agreement by the Employer shall be for “Cause” for the purpose of this Section 4.5 if terminated by the
Employer as a result of: (a) a material breach of the Employment Agreement by the Employee, where the Employer has provided notice to the Employee of such breach and the Employee shall have failed to cure such material breach within 15 days
after receipt of said notice; (b) an act of gross misconduct by the Employee or repeated or continued (after written warning) other serious breach of the Employee’s instructions of the CEO and/or CFO of Invitel/HTCC; (c) the Employee
being convicted of any criminal offence punishable with imprisonment which directly or indirectly harms the Employer or any Affiliate of the Employer, or prevents the Employee from performing its employment obligations; (d) the Employee having
committed any material act of dishonesty relating to the Employer or an Affiliate of the Employer or any of its employees or otherwise; or (e) the repeated or continued (after written warning) underperformance of the Employee of his/her tasks
and duties in his/her capacity as employee of the Employer, such underperformance to be determined in the sole discretion of the CEO and/or CFO of Invitel/HTCC. 
 A termination of the Employment Agreement by the Employee shall be for “Good Reason” for the purpose of this Section 4.5 if terminated by the Employee as a result of a breach by the Employer and/or any
of its Affiliates of any material provision of the Employment Agreement or any other agreement between the Employer or any of its Affiliates and the Employee. 
 Sections not affected by this Amendment Agreement shall remain unchanged. 
  

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	 INVITEL Távközlési Szolgáltató
 Zártköruen Muködo Részvénytársaság
 Employer

	 		 	 Vágány Tamás
 Employee

  

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 Exhibit A 
 Upon the completion of a Trigger Event, as described in Section 4.4 above, the Transaction Bonus shall be calculated as follows: 
  

	1.	3.85% of U.S.$ 4 million, plus 

  

	2.	3.85% of the net present value (using a discount rate of 10% per annum) of 10% of the increase in the equity value of the Employer implied by the increase in the Per Share
Consideration (as defined below) over the Agreed HTCC Share Price, but not less than zero, plus 

  

	3.	the net present value (using a discount rate of 10% per annum) of the amount in U.S. dollars by which the Per Share Consideration is greater than U.S.$ 14.69 multiplied by
40,133. 

 “Per Share Consideration” shall mean the per share fair market value of any consideration to be paid to shareholders of
HTCC common stock in connection with any Trigger Event. 
 For purposes hereof, equity value shall be determined by multiplying the Per Share Consideration
or the Agreed HTCC Share Price, as the case may be, by the total number of shares of HTCC common stock outstanding, on a fully-diluted basis, on the date of the Trigger Event, in the case of the Per Share Consideration and on 27 April 2007, in
the case of the Agreed HTCC Share Price. 
 The table below sets forth for illustrative purposes the amount of the Transaction Bonus owing to the Employee
presuming the occurrence of a Trigger Event on 27 April 2008 at the different Per Share Consideration levels set forth below: 
  

			
	 Per Share Consideration
	  	 Transaction Bonus Amount

	U.S.$ 19.00	  	U.S.$ 540,000
	U.S.$ 20.00	  	U.S.$ 630,000
	U.S.$ 21.00	  	U.S.$ 720,000
	U.S.$ 22.00	  	U.S.$ 810,000
	U.S.$ 23.00	  	U.S.$ 900,000

 In the event of any change in the outstanding HTCC common stock as a result of any stock split, spin-off, stock
dividend, reverse stock split, stock combination, or reclassification, recapitalization, or similar event, the HTCC Agreed Share Price shall be adjusted appropriately to take account of such change. 
  

 14Amended and Restated Supply Agreement

 Exhibit 10.1 
 AMENDED AND RESTATED SUPPLY AGREEMENT 
 THIS AMENDED AND RESTATED SUPPLY AGREEMENT (the “Agreement”) is entered into this 25th day of May, 2007 (the
“Effective Date”) by and between PLANTEX USA, Inc., a corporation organized under the laws of the State of New Jersey with offices at 2 University Plaza, Suite 305, Hackensack, New Jersey 07601 (“PLANTEX”) and
NOVACEA, Inc. (formerly known as D-Novo Therapeutics, Inc.) a corporation organized under the laws of the State of Delaware with offices at 601 Gateway Blvd., Suite 800, South San Francisco, Ca 94080 (“NOVACEA”) and hereby amends
and restates that certain Supply Agreement as amended on or about January 24, 2006, March 21, 2006 and March 13, 2007 (the “Original Agreement”) entered into between the parties effective as of 27th day of December, 2001 (the “Original Effective Date”). 
 WITNESSETH 
 WHEREAS, the parties have entered into the Original
Agreement pursuant to which PLANTEX (or an Affiliate thereof) will supply NOVACEA Active Pharmaceutical Ingredients, or API, (as defined below) for the Finished Product (as defined below) and NOVACEA (including Affiliates thereof and their
respective licensees and contract manufacturing vendors, if any) will purchase from PLANTEX requirements as set forth below, of API used in the manufacture of Finished Product; and 
 WHEREAS, this Agreement is an amendment and restatement of the Original Agreement, and completely supersedes and replaces the Original Agreement.

 NOW, THEREFORE, in consideration of the premises and of the mutual covenants and agreements set forth in this Agreement, the parties agree
as follows: 
  

	1.	DEFINITIONS  

 The following words and phrases
shall, for purposes of this Agreement, have the following meanings (with any term or phrase referred to below, or defined elsewhere in this Agreement, in the singular to include the plural and vice versa as the context requires): 
 “Action” shall mean any suit, action, investigation (governmental or otherwise), claim or proceeding initiated or filed against a party
to this Agreement, which results in or could result in a Loss or Losses for which indemnification is required by the other party under Article 13 below. 
 “Active Pharmaceutical Ingredients” or “API” shall mean bulk, unformulated Calcitriol. 
 “Affiliate” of any party shall mean any Person that is controlled by, controls, or is under common control with such party. For this purpose, “control” of a corporation or other
business entity shall mean the direct or indirect beneficial ownership of more than fifty percent (50%) in the equity of, or the right to appoint more than fifty (50) percent of the directors or management of such corporation or other
business entity. 

 “Agreement” shall mean this Agreement as it is amended from time to time in the manner
provided herein. 
 “ANDA” shall mean an Abbreviated New Drug Application filed with the FDA pursuant to its rules and
regulations. 
 “Approval” shall mean any and all approvals, licenses, registrations or authorizations of the applicable
Regulatory Authority necessary for the marketing of Finished Products in the relevant country in the Territory. 
 “cGMP”
shall mean current good manufacturing practices as set forth in regulations issued by the FDA from time to time. 
 “Commercialization Partner” shall mean a commercial entity with global annual human pharmaceutical gross revenues of at least [*] dollars ($[*]). 
 “Contract Year” shall mean the twelve (12) month period measured from a specific date or event. 
 “DMFs” shall mean the drug master files covering the analysis and manufacture of the API, comprising any and all technical information
in the possession of PLANTEX (or an Affiliate thereof), including, without limitation, analytical methods, stability and pharmaceutical data, impurities, and manufacturing processes with respect to the API. 
 “Effective Date” shall mean May 25, 2007. 
 “Finished Products” or “Finished Product” shall mean such pharmaceutical products developed and/or marketed by NOVACEA for the treatment and/or prevention of any cancer containing API
as shall receive Approval for marketing by a Regulatory Authority. 
 “FDA” shall mean the United States Food and Drug
Administration and all agencies under its direct control or any successor organization. 
 “FFDCA” shall mean the Federal
Food, Drug and Cosmetic Act of 1934, as amended from time to time, and the regulations promulgated pursuant thereto, or any successor statute adopted to replace such act. 
 “Indemnified Party” shall mean the party to this Agreement entitled to be indemnified by the Indemnifying Party against a Loss or Losses pursuant to Article 13 below. 
 “Initial Launch” means the date on which NOVACEA (or any of its Affiliates or their respective licensees, if any) makes its first
commercial sale in the Territory of any Finished Product to an unaffiliated third party. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

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 “Loss” or “Losses” shall mean any liability, loss, costs, damage or
expense, including reasonable attorneys’ fees and expenses, incurred or suffered by a party to this Agreement, except for consequential damages, for which indemnification is required under Article 13 below. 
 “Manufacture” and “manufacturing” and other forms of such word or phrase shall refer to the manufacturing, handling,
packaging, storage and/or disposal of the API and the raw materials and components used in connection therewith. 
 “NDA”
means a New Drug Application filed with the FDA pursuant to its rules and regulations. 
 “Original Agreement” means that certain Supply Agreement entered into between the parties effective as of 27th day of December,
2001 and as amended on or about January 24, 2006, March 21, 2006 and March 13, 2007. 
 “Original Effective Date” means 27th day of December, 2001. 
 “Party” or “Parties”, when referring to the parties to this Agreement shall mean and include PLANTEX and NOVACEA, or
each of them individually. 
 “Person” shall mean any individual, partnership, association, corporation, trust or legal
person or entity. 
 “Regulatory Authority” shall mean any and all governmental bodies, organizations and agencies whose
approval is necessary to develop, manufacture, import, use, and or market Finished Products in the relevant country of the Territory 
 “Territory” shall mean worldwide. 
  

	2.	TERM  

 The initial term of this Agreement shall begin on the Original Effective Date and unless terminated in the manner provided in Article 14 hereof, shall expire upon the expiration of the greater of (i) ten
(10) Contract Years from the Original Effective Date or (ii) the tenth (10th) anniversary of the date occurring prior to the tenth
anniversary of the Original Effective Date that NOVACEA receives marketing approval for Finished Product from the FDA (“Initial Term”). NOVACEA shall notify PLANTEX in writing within five (5) days following receipt of such
marketing approval. This Agreement shall be automatically extended upon the same terms and conditions for successive two (2) year periods (“Renewal Term”) unless either Party shall have provided notice of its intent not to
renew this Agreement not less than one (1) year prior to expiration of the Initial Term or any Renewal Term then in effect. For purposes of this Agreement “Term” shall refer collectively to the Initial Term and the Renewal
Terms, unless the context otherwise requires. 
  

	3.	SCOPE OF THE AGREEMENT  

 This Agreement shall apply
to purchases during the Term by NOVACEA (and its 

  

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Affiliates and their respective licensees and contract manufacturing vendors, if any) of API and their respective, direct or indirect, successors and
permitted assigns, for the development, commercialization, distribution and sale of Finished Product in the Territory. 
  

	4.	DEVELOPMENT EFFORT  

 NOVACEA agrees at its sole
cost and expense to use its best efforts to obtain Approval to market Finished Product in such countries in the Territory as shall be reasonably determined by NOVACEA, except that NOVACEA shall use its best efforts to obtain FDA Approval to market
Finished Product in the United States based upon a NDA or ANDA, as shall be determined by NOVACEA. Notwithstanding the foregoing, if NOVACEA enters into an agreement with an effective date of no later than [*] with a Commercialization Partner to
commercialize the Finished Product, then the standard above shall not apply and instead the standard provided in NOVACEA’s agreement with such Commercialization Partner shall apply which will at least be a commercially reasonable efforts
standard. Alternatively, if this Agreement is assigned to such Commercialization Partner, then the standard applicable to the Commercialization Partner shall be the commercially reasonable efforts standard. In connection with the FDA Approval
described above, NOVACEA shall at its sole cost and expense conduct all tests and studies reasonably required to enable NOVACEA to apply for, obtain and maintain FDA Approval for Finished Product. In connection with the development of Finished
Product and securing any Approvals, NOVACEA agrees, on behalf of itself, its Affiliates and their respective licensees or contract manufacturing vendors, if any, to use only API obtained from PLANTEX (or its Affiliates) and from the second source
that NOVACEA proposes to utilize pursuant to Section 5.1 below, and purchase all their respective development requirements of API from PLANTEX (or its Affiliates) and such second source. Upon the execution and delivery of this Agreement,
PLANTEX shall provide and deliver to NOVACEA without charge two (2) grams of API. Thereafter, NOVACEA shall be charged [*] dollars ($[*]) per gram for Developmental Orders (as herein defined) of API sold hereunder and such price shall not be
subject to increase or decrease. Notwithstanding Section 6.2 below, such payment shall be due and payable upon delivery to NOVACEA of any Developmental Order or portion thereof. As used herein, “Developmental Orders” means
orders placed prior to Approval by a Regulatory Authority and not in connection with commercial production in connection with commercial launch following any such Approval. After January 1, 2008, all Developmental Orders shall be minimum
noncancellable orders for quantities of not less than [*] grams each, such quantities currently forecasted by NOVACEA at [*] grams for 2008, [*] grams for 2009 and [*] grams for 2010. For Developmental Orders on an annual basis after 2010, NOVACEA
shall notify PLANTEX of its minimum noncancellable quantities for the applicable year (not to be less than [*] grams each year) no later than September 30 of the preceding calendar year. Each of the Developmental Orders shall be deliverable
over periods not exceeding twelve (12) months, in partial shipments of not less than [*] grams each and not greater than [*] grams each; provided that PLANTEX shall use commercially reasonable efforts to deliver to NOVACEA or its designee
quantities set forth in a Developmental Order quarterly shipments of no less than [*] percent ([*]%) of the applicable Developmental Order. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

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	5.	COMMERCIAL SUPPLY.  

 5.1 NOVACEA Purchases.
(i) NOVACEA covenants and agrees for and on behalf of itself, its Affiliates and their respective licensees and contract manufacturing vendors, if any, that each of them shall purchase from PLANTEX or its designated Affiliates at least [*]
percent of its annual requirements of API used by it in connection with its manufacture, sale and distribution of Finished Products within the Territory; provided, however, that NOVACEA together with any of its Affiliates, licensees or contract
manufacturing vendors, shall not in any calendar year purchase from any source other than PLANTEX or its designated Affiliates more than an amount sufficient to maintain qualification of a second source supplier (which amount shall be at least [*]
grams and no more than [*] grams of API), but may purchase up to such [*] gram amount, notwithstanding such [*] percent ([*]%) requirement, if such amount is necessary to keep a second manufacturing source qualified under Section 5.2 below. Any
license or contract manufacturing agreement for the benefit of NOVACEA or any of its Affiliates shall contain a provision requiring such licensee or contract manufacturer to purchase from PLANTEX or its designated Affiliate no less than [*] percent
of such party’s annual requirements of API for use in connection with the manufacture, sale or distribution of Finished Product in the Territory upon the terms and conditions applicable to purchases hereunder by NOVACEA, and barring such party
from purchasing from any source other than PLANTEX or its designated Affiliate any amount of API that would result in an aggregate purchase of more than an amount sufficient to maintain qualification of a second source supplier (which amount shall
be at least [*] grams and no more than [*] grams of API in any calendar year for use by NOVACEA, its Affiliates and their respective licensees and contract manufacturers, subject to the ability to purchase up to such amount, notwithstanding such [*]
percent ([*]%) requirement, if such amount is necessary to keep a second manufacturing source qualified for the purpose of Section 5.2 below. Any such license or contract manufacturing agreement shall make specific reference to this Agreement
and state with affirmative language that PLANTEX shall have the rights of a third party beneficiary with respect to such agreement. 
 (ii)
NOVACEA covenants that, to the extent that NOVACEA or its Affiliates or licensees or contract manufacturers elect to purchase from a source other than PLANTEX or its designated Affiliates any API for use in connection with its manufacture, sale and
distribution of Finished Products within the Territory, NOVACEA shall treat as confidential and not disclose to such source any PLANTEX Confidential Information (as defined in Section 16.1, below) including, without limitation, PLANTEX’s
product manufacturing procedures, levels of impurities, certified analytical standards and analytical methods, and shall cause its Affiliates, licensees and contract manufacturers to comply with this covenant. 
 (iii) Within sixty (60) days after the last day of each calendar year commencing the calendar year of first commercial sale of Finished Product in
the United States, NOVACEA shall certify to PLANTEX in writing that: (i) neither NOVACEA nor any Affiliate or licensee or contract manufacturing vendor of NOVACEA or its Affiliates has in such calendar year purchased from any source other than
PLANTEX or its designated Affiliates API for use in connection with the manufacture, sale or distribution of Finished Product in the Territory in excess of the amounts 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

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permitted in Section 5.1(i), above, and (ii) neither NOVACEA nor any of its Affiliates, licensees or contract manufacturing vendors has disclosed
to any third party any PLANTEX Confidential Information in violation of the covenant set forth in Section 5.1(ii), above. PLANTEX shall have the right, not more than once each calendar year, during normal business hours and on at least ten
(10) business days’ advance notice to NOVACEA, to inspect the books and records and facilities of NOVACEA and its Affiliates to confirm the accuracy of the certification made by NOVACEA pursuant to this Section 5.1(iii). 

(iv) Subject to Section 13.2 below, in the event that NOVACEA is in breach of either of its covenants set forth in Sections 5.1(i) and 5.1(ii),
above, then PLANTEX shall be entitled to seek all damages and other legal remedies resulting from such breach, including without limitation, the right to terminate this Agreement as provided in Section 14.1(ii), below. 
 5.2 Exception. During any period in which PLANTEX, for any reason, including but not limited to force majeure as provided for in Section 15,
fails to supply, is unable to supply or anticipates that it will be unable to supply, the quantities of API to NOVACEA included within any Firm Purchase Order (as defined below) or any other purchase order confirmed in writing by PLANTEX, NOVACEA
shall be free to fill such specific purchase order for API (or any unfilled portion) from an alternative source. This shall be the sole remedy for NOVACEA in the event that PLANTEX advises that it is unable to supply API. PLANTEX shall notify
NOVACEA promptly upon becoming aware of any facts or circumstances, which causes it to believe that it will be unable to meet shipment obligations hereunder. For clarity, notwithstanding any other term or provision of this Agreement, for purposes of
exercising NOVACEA’s rights under Section 5.1 to purchase up to [*] percent ([*]%) of its requirements from third parties and this Section 5.2 for failure to supply, NOVACEA may enter into discussions with potential alternative
sources and conduct any and all activities necessary (subject to Section 5.1(ii) to validate and qualify an alternative source as a suitable alternative source supplier, at any time during the term of this Agreement, so that a qualified
alternative source supplier will be available for the manufacture of API as permitted by Section 5.1 and this Section 5.2. 
 5.3
Sole Supply. PLANTEX shall not supply API to any other entity during the Term of this Agreement for use in the field of the treatment, diagnosis, and/or prevention of any cancer, except for a pharmaceutical product that in the reasonable
judgment of NOVACEA shall not be in direct competition with NOVACEA’s approved NDA Product, such determination to be made by NOVACEA promptly following the written request therefore by PLANTEX. 
 5.4 Specifications. PLANTEX shall provide with each shipment of API a certificate of analysis. PLANTEX (or an Affiliate thereof) shall file and
maintain a valid DMF for the API with the FDA, which is in full compliance with FDA requirements for DMFs. Provided that NOVACEA is not in material breach of its obligations hereunder, NOVACEA, its Affiliates, or licensees, shall have the right to
reference PLANTEX’s DMF for API in any drug application seeking Approval for Finished Product from a Regulatory Authority. All API shall be manufactured in accordance with cGMP and shall meet the specifications set forth in Schedule A
annexed to this Agreement. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

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 5.5 Forecasts and Purchase Orders. [*] months prior to the date on which NOVACEA, in good faith,
anticipates Approval, NOVACEA will provide PLANTEX with [*] month rolling forecasts of its requirements by calendar quarter for API. Thereafter, such rolling forecasts shall be delivered to PLANTEX on or before the fifteenth (15th) day of each
calendar quarter during the Term. The first calendar quarter of each [*] month rolling forecast shall be binding on PLANTEX and NOVACEA and shall constitute a firm purchase order (“Firm Purchase Order”) for the API indicated for
such calendar quarter. PLANTEX shall supply NOVACEA with (i) the quantities set forth on each such Firm Purchase Order and (ii) such additional amounts as NOVACEA may order in excess of its forecasted amounts for such calendar quarter,
provided that PLANTEX shall have confirmed and accepted such additional orders within thirty (30) days of PLANTEX’s receipt of NOVACEA’s written request for such additional amounts. PLANTEX agrees to use commercially reasonable
efforts to meet any such additional orders. In the event that PLANTEX determines, based in part on NOVACEA’s good faith [*] month rolling forecast, on a consistent basis and in accordance with PLANTEX’s standard accounting practices, in
good faith (other than for reasons of force majeure as provided for in Section 15, below), that its revenues derived from manufacturing API are not equal to or exceed the costs for manufacture of API, and that it will therefore discontinue the
manufacture of API worldwide and terminate its delivery obligations to NOVACEA, and any other third party, by giving to NOVACEA not less than [*] months prior written notice, NOVACEA and/or its licensees shall have the right, within the first [*]
months of such [*] month period, to make a minimum [*] month purchase commitment in an amount sufficient to bring such revenues to a level equal to manufacturing costs plus [*] percent, in which case PLANTEX shall not be entitled to discontinue the
manufacture of API and terminate its delivery obligation hereunder, but will instead be obligated to continue the manufacture and delivery of API, as required by NOVACEA or its licensee. The terms and conditions of this Agreement shall apply to all
purchase orders hereunder and if any terms and conditions contained in such purchase orders shall conflict with any terms and conditions contained herein, the terms of this Agreement shall control. No additional terms or conditions set forth in any
such purchase order (other than the quantities and delivery dates set forth therein and conforming to the provisions of this Agreement) shall be binding upon PLANTEX, unless agreed to in writing by PLANTEX. Any additional terms therein contained
shall be deemed to be a proposed offer of amended terms that shall be deemed rejected by PLANTEX and of no force or effect, notwithstanding any action or inaction by PLANTEX other than its express written approval of such additional terms.

 5.6 Capacity. PLANTEX covenants to maintain capacity to manufacture on an annualized basis [*] percent of the forecasted
requirements of API set forth in any [*] month forecast submitted by NOVACEA in accordance with this Agreement, provided that the forecasted amount does not exceed the forecasted amount for the preceding year by [*] percent or more. Additionally,
following FDA Approval of Finished Product and continuing for the Term, PLANTEX shall maintain a six (6) month supply of API, based upon NOVACEA’s then-current forecasted amount. In order to further secure a supply of API hereunder,
PLANTEX shall develop a production contingency plan (which plan shall be presented to NOVACEA for its approval, which approval shall not be unreasonably withheld) designed to relocate the API site listed in the 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

 -7- 

 
DMF for API or utilize an additional site in the event that PLANTEX makes a good faith determination that it is necessary to relocate such site or to utilize
an additional site in order to meet NOVACEA’s requirements of API. Such plan shall contemplate completion of relocation and securing necessary regulatory approvals within [*] of the determination by PLANTEX that such relocation was required. In
the event that relocation has not been completed within such [*] period, NOVACEA’s sole remedy shall be to terminate this Agreement. 
 5.7 Quality Agreement. Within ninety (90) days of the Effective Date, the parties shall execute a quality agreement (“Quality Agreement”), which sets out the responsibilities of the parties in connection with
the (i) API as they are related to quality control and quality assurance and (ii) the compliance with the European Union’s GMP regulation requiring the GMP status of the API manufacturer to be assured by the marketing authorization
holder or the final product manufacturer. In the event of a conflict between the terms of this Agreement and the Quality Agreement, this Agreement shall control. 
 5.8 Recordkeeping. NOVACEA shall keep and maintain or cause to be maintained books and records, pertaining to the use of API by NOVACEA and its Affiliates and their respective licensees or contract
manufacturing vendors, if any, in the manufacture, sale or distribution of Finished Products within the Territory, sufficient to enable PLANTEX to verify and confirm compliance by NOVACEA with the terms and conditions of this Agreement, including,
without limitation, the purchase of all requirements obligations in this Agreement. Such books and records shall be maintained in accordance with U.S. generally accepted accounting principles consistently applied. NOVACEA shall permit an independent
accounting firm selected by PLANTEX and acceptable to NOVACEA, at reasonable times and upon reasonable notice, to have access during normal business hours to the books and records of NOVACEA (and its Affiliates) as may be necessary to verify and
confirm compliance with the terms of this Section 5.8 with respect to use and inventory of API. The costs of any such examination shall be borne by PLANTEX unless it shall be determined that the quotient, q/r, expressed as a percentage, is less
than [*] percent, when (q) equals the aggregate quantities expressed in kilograms of API purchased from PLANTEX (or its Affiliates) by NOVACEA and its Affiliates, and their respective licensees or contract manufacturing vendors if any, for use
in the manufacture, sale or distribution of Finished Product in the Territory, and (r) equals the aggregate quantities expressed in kilograms of API purchased from all sources by NOVACEA and its Affiliates and their respective licensees and
contract manufacturing vendors, if any, for use in the manufacture, sale or distribution of Finished Product in the Territory, in which event NOVACEA shall reimburse PLANTEX all reasonable costs and expenses of such examination. PLANTEX shall keep
and maintain or cause to be maintained books and records pertaining to the manufacture of API for at least five (5) years or as required by law, whichever is longer. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

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	6.	PRICE; PAYMENTS; DELIVERY  

 6.1 Price

 6.1.1 The price payable to PLANTEX hereunder for API shall be [*] dollars ($[*]) per gram. During development of the Finished Product,
PLANTEX agrees not to increase the price of API with respect to developmental quantities. At such time as NOVACEA receives FDA approval to market Finished Product, , provided that NOVACEA purchases not less than [*] grams of API in the first
Contract Year following Approval by a Regulatory Authority and in each Contract Year after the second anniversary of such Approval, the maximum price payable for API hereunder shall be [*] dollars ($[*]) per gram, except that such pricing may be
adjusted upwards for changes in the Consumer Price Index as follows: after the first anniversary of the Effective Date, prices charged following Approval by a Regulatory Authority in any Contract Year following the date hereof shall be determined by
multiplying the price of [*] dollars ($[*]) per gram by a fraction x/y, when (x) shall equal the Current Index (as herein defined) and (y) equals the Base Index (as herein defined). As used herein the Current Index shall be the Consumer
Price Index – All Urban Consumers (CPI-U), as published by the United States Department of Labor over the twelve (12) month period reported in such index immediately preceding the first day of each such Contract Year herein. The Base Index
shall be the Consumer Price Index – All Urban Consumers (CPI-U), as published by the United States Department of Labor for November 2001 (Base Index of 100). Commencing with the third anniversary of the Effective Date, once, during each
Contract Year thereafter, PLANTEX agrees to negotiate in good faith a price adjustment provided that NOVACEA can demonstrate that API is otherwise available, upon comparable terms and conditions as provided for herein, from an alternative supplier
(other than NOVACEA or any Affiliate thereof) holding an approved FDA DMF and offering such API at a price that is more than [*] percent below the price offered by PLANTEX herein. NOVACEA shall be relieved of the requirements purchase obligations
set forth in Section 5.1 of this Agreement and PLANTEX shall not be subject to the sole supply provisions set forth in Section 5.3 of this Agreement for such Contract Year or any subsequent Contract Year if, despite such good faith
negotiations, NOVACEA and PLANTEX are unable to reach a mutually satisfactory price within forty-five (45) days of the date on which NOVACEA notifies PLANTEX of such pricing availability. Nothing contained herein to the contrary shall require
PLANTEX to supply API at the pricing offered by any third party supplier. Additionally, PLANTEX and NOVACEA agree that they shall from time to time during the Term of this Agreement negotiate in good faith reductions in the price payable per gram
based on (i) NOVACEA purchases of quantities of API in excess of [*] grams in a Contract Year or (ii) a significant reduction in PLANTEX’s costs to manufacture API. Following the date of Initial Launch, PLANTEX shall give NOVACEA
prompt notice of any significant reduction in PLANTEX’s costs to manufacture API. Such reduction shall initially be determined based on PLANTEX’s costs to manufacture API as of the date of Initial Launch. PLANTEX’s costs to
manufacture API shall be determined from year to year on a consistent basis and in accordance with PLANTEX’s standard accounting practices. For purposes hereof, a “significant reduction” shall mean a reduction of [*] percent or
more, calculated on a cumulative basis (i.e., the reduction may occur over a period of greater than one (1) year). On each anniversary of the Effective Date, PLANTEX shall give NOVACEA notice of PLANTEX’s costs to manufacture API as of
such date. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

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 6.1.2 The prices hereunder are F.O.B. PLANTEX’s facilities in New Jersey. 
 6.2 Payments  
 NOVACEA shall pay all
invoices net within thirty days (30) days of invoice date by bank wire transfer, by automated clearinghouse (electronic funds transfer) or by such other means as the parties may otherwise agree to in United States Dollars in the requisite
amount to such bank account as PLANTEX may from time to time designate. In the event that NOVACEA is delinquent in payment of invoices hereunder beyond the terms granted, PLANTEX, in its discretion, may suspend further shipments of API. Amounts not
paid when due shall accrue interest payable at the rate of twelve (12) percent per annum, not to exceed the maximum rate of interest permitted by law. Any such interest charges shall be due and payable on demand. 
 6.3 Delivery; Risk of Loss 
 Delivery
of all API sold by PLANTEX to NOVACEA hereunder shall be made, and title thereto and risk of loss thereof shall pass, to NOVACEA upon receipt of the API by NOVACEA at NOVACEA’s facility. 
  

	7.	INTENTIONALLY LEFT BLANK 

  

	8.	WARRANTIES; ACCEPTANCE AND CLAIMS 

 8.1 Limited
API Warranty. PLANTEX represents and warrants to NOVACEA that at the time of sale and delivery of API hereunder by PLANTEX, (i) the API manufactured and supplied will conform to the applicable specifications for API set forth on Schedule
A hereto, (ii) will have been manufactured, stored and packaged for shipment in accordance with cGMP in effect at the time thereof, and also in accordance with applicable laws, regulations and policies, including, but not limited to those
of the FDA, (iii) will not be adulterated or misbranded by PLANTEX or any other PLANTEX Affiliate within the meaning of the FFDCA, and (iv) will be free from defects. THE FOREGOING WARRANTY IS EXCLUSIVE AND IN LIEU OF ALL OTHER WARRANTIES
EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. 
 8.2
Notification of Defects. All API shall be received subject to NOVACEA’s inspection and may be rejected if any such API fails to be delivered in the condition warranted. NOVACEA shall be deemed to have accepted each order of API if
PLANTEX does not receive written notice to the contrary as set forth in this Section 8.2. NOVACEA shall notify PLANTEX in writing within forty-five (45) working days after delivery to NOVACEA of any non-conforming API containing obvious
defects discoverable without affecting the integrity of the APl’s packaging and will notify PLANTEX of nonconformity within thirty (30) working days from its discovery at any time of any latent defects, or NOVACEA’s rights as to such
obvious or latent non-conformance shall be waived. At PLANTEX’s request, NOVACEA shall promptly 

  

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supply either samples of the API that are allegedly defective or some other evidence of deficiency that PLANTEX shall specify. If there is a disagreement
between the Parties as to whether any API conforms to specifications, or meets the warranties set forth in Section 8.1 above, then samples and/or batch records, as appropriate, from the batch that is in dispute promptly will be submitted for
testing and evaluation to an independent testing laboratory as shall be agreed to in writing by both Parties. The determination of such independent testing laboratory shall be binding upon the parties. If it is determined that the nonconformity is
due to damage to API (a) caused by NOVACEA or its agents or (b) which occurs subsequent to delivery of such API to NOVACEA, PLANTEX shall have no liability to NOVACEA with respect to such nonconformity and the cost of any testing and
evaluation by such testing laboratory shall be borne by NOVACEA. If it is determined that the nonconformity was not the result of either (a) or (b) above, then PLANTEX shall credit NOVACEA’s account for the price invoiced for such
nonconforming API (or if payment therefor has previously been made by NOVACEA, pay NOVACEA the amount of such credit or offset the amount thereof against other amounts then due to PLANTEX. 
 8.3 Notification. PLANTEX shall notify NOVACEA immediately in the event it discovers facts or circumstances that could adversely affect the
APl’s conformance to specifications or that would cause PLANTEX not to meet any of its warranties with respect to the API. 
 8.4
Returns. PLANTEX shall accept for return and replacement any API manufactured and supplied to NOVACEA under this Agreement which does not conform with any warranty set forth above and for which proper notice has been given, provided NOVACEA
obtains prior shipping authorization from PLANTEX. This shall be NOVACEA’s sole remedy for claims that any API failed to comply with the warranties provided in Section 8.1 herein. All returns of API with obvious defects shall be in the
original manufactured condition. PLANTEX will pay reasonable return freight and shipping charges, but NOVACEA shall assume the risk of loss in transit associated with such returns. 
  

	9.	DEBARMENT  

 Each party represents and warrants to
the other that neither it nor any of its officers, directors, or employees performing services under this Agreement has been debarred, or convicted of a crime which could lead to debarment, under the Generic Drug Enforcement Act of 1992, 21 United
States Code Sec. 306 (a) and (b). In the event that either party, or any of its officers, directors, or employees performing services under this Agreement, (a) becomes debarred or receives notice of action or threat of action with respect
to its debarment or (b) becomes the object of any investigation or subject of any report regarding such party, or any of its officers, directors, or employees performing services under this Agreement, in connection with any activity that could
result in debarment or suspension or refusal of approval, including without limitation any inspection report, warning letter, notice of opportunity for hearing in a case of debarment, or any other Justice Department, FDA or other federal or state
government inquiry or action bearing on potentially illegal activities, such party shall notify the other party immediately. 
  

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	10.	FDA INSPECTIONS AND COMMUNICATIONS 

 PLANTEX shall
promptly notify NOVACEA of any FDA notices of violation or deficiency letters relating to the API. Each party shall promptly deliver to the other party all reports, data information and correspondence received by it from the FDA or any state or
local authority with respect to the API (or Finished Product) and any cGMP issues relating thereto and any written response information, data or correspondence delivered by such party to the FDA at any state or local authority with respect to the
API and shall cooperate to the extent reasonably requested by such other party in its response to the FDA or such other state or local authority. 
  

	11.	COMPLAINT HANDLING ADVERSE DRUG REACTION REPORTS 

 11.1 Complaint Handling. Except as otherwise provided below in Section 11.2, in the event that PLANTEX or NOVACEA receives any complaint, claims or adverse reaction reports regarding Finished Product, including notices from the
FDA regarding any alleged regulatory non-compliance of the Finished Product, each party shall, within five (5) business days, provide the other with all information contained in the complaint, report, or notice and such additional information
regarding the Finished Product as may be reasonably requested, except that notification by NOVACEA to PLANTEX shall be required only in those instances where any such complaint, claim or adverse reaction report appears to be related to API or where
in the exercise of reasonable judgment NOVACEA concludes or should conclude that such report contains information that may bear upon or relate to the possibility of prospective liability on the part of PLANTEX (or any Affiliate thereof). NOVACEA and
PLANTEX shall comply, at a minimum, with FDA and cGMP requirements for complaint handling. 
 11.2 Adverse Drug Reaction Reports.
NOVACEA shall maintain a system for monitoring, investigating and following up on adverse reaction reports received by it involving the Finished Product. If either party becomes aware that the Finished Product contains a defect which could or did
cause death or injury, each party shall immediately by FAX and telephone provide the other with a complete (where required by law) description of all relevant details known to such party concerning any such incident, including but not limited to, a
description of any defect and such other information which may be necessary to report the incident to the FDA, except that notification by NOVACEA to PLANTEX shall be required only in those instances where such defect relates to or appears to relate
to the API. NOVACEA will be responsible for preparing adverse drug reaction reports, administering adverse drug reaction files relating to the API and filing all such reports with FDA, at its sole expense. 
  

	12.	ACCESS TO FACILITIES AND AUDIT RIGHTS 

 12.1 Upon
reasonable notice, NOVACEA shall have the right, exercisable upon prior written notice no more frequently than on an annual basis, during normal business hours, with a maximum of two (2) persons, to inspect those areas of the facilities where
API is manufactured for NOVACEA (or its Affiliates) and to review the pertinent records relating to the manufacturing, packaging and quality control of the API. 
 12.2 PLANTEX agrees to keep full, clear and accurate books and records with respect 

  

 -12- 

 
to costs of commercial manufacture of API for a minimum period of three (3) years after the relevant cost determination is made pursuant to
Section 5.5. PLANTEX further agrees, upon reasonable prior notice, to permit such books and records to be examined during normal business hours by an independent nationally recognized accounting firm selected by NOVACEA and reasonably
acceptable to the PLANTEX for the purpose of verifying the cost plus [*] percent price under Section 5.5. Such audit shall not be performed more frequently than once per calendar year nor more frequently than once with respect to records
covering any specific period of time and shall be conducted under appropriate confidentiality provisions, for the sole purpose of verifying the accuracy and completeness of the financial, accounting and numerical information and calculations
provided in Section 5.5. Such examination is to be made at the expense of NOVACEA, except in the event that the results of the audit reveal an overpayment of for API of [*] percent ([*]%) or more over the period being audited, in which case
reasonable audit fees for such examination shall be paid by PLANTEX. 
  

	13.	INDEMNIFICATION 

 13.1
Indemnification. PLANTEX shall indemnify, defend, save and hold NOVACEA and each of its Affiliates, officers, directors, employees and agents harmless from and against Loss or Losses resulting from, or arising out of any material breach of
any warranty or material non-fulfillment or non-performance by PLANTEX of any agreement, covenant or obligation of PLANTEX under this Agreement. PLANTEX shall not be liable hereunder for any Loss or Losses resulting from any settlement of any claim,
litigation or proceeding effected without its consent, which consent shall not be unreasonably withheld.  
 NOVACEA shall indemnify,
defend, save and hold PLANTEX and each of its Affiliate, officers directors, employees and agents harmless from and against Loss or Losses resulting from, or arising out of (a) any material breach of any warranty or material non-fulfillment or
non-performance by NOVACEA of any agreement, covenant or obligation of NOVACEA contained in this Agreement; (b) any actual or alleged defect in any Finished Product sold by NOVACEA or any of its Affiliates or their respective licensees, if any,
not resulting from a material breach of this Agreement by PLANTEX; (c) any alleged infringement or violation of any patent, trade secret or proprietary rights used by NOVACEA or any of its Affiliates or their respective licensees or contract
manufacturing vendors, if any, in manufacturing, importing or selling of Finished Product, or (d) FDA enforcement action, inspection or Finished Product recalls or market withdrawals resulting from NOVACEA’s or any of its Affiliates or
their respective licenses or contract manufacturing vendors, if any, failure to manufacture Finished Product in accordance with all applicable laws, rules, orders or regulations. 
 13.2 Limitation of Liability. IN NO EVENT SHALL ANY PARTY BE LIABLE TO THE OTHER UNDER ANY PROVISION OF THIS AGREEMENT OR UNDER ANY CONTRACT,
NEGLIGENCE, STRICT LIABILITY OR OTHER LEGAL OR EQUITABLE THEORY FOR ANY RESULTANT, INDIRECT, SPECIAL OR EXEMPLARY DAMAGES OR, SPECIFICALLY, CONSEQUENTIAL DAMAGES OR DAMAGE TO GOODWILL AND REPUTATION. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

 -13- 

 13.3 Survival. The terms and conditions of Section 13 shall survive any termination of this
Agreement. 
 13.4 Indemnification Procedures. Upon the occurrence of an event that requires indemnification under this Agreement, the
Indemnified Party shall give prompt written notice to the Indemnifying Party providing reasonable details of the nature of the event and basis of the indemnity claim. The Indemnifying Party shall then have the right, at its expense and with counsel
of its choice, to defend, contest, or otherwise protect against any such Action. The Indemnified Party shall also have the right, but not the obligation, to participate, at its own expense in the defense thereof with counsel of its choice. The
Indemnified Party shall cooperate to the extent reasonably necessary to assist the Indemnifying Party in defending, contesting or otherwise protesting against any such Action provided that the Indemnifying Party shall pay the reasonable cost in
doing so. If the Indemnifying Party fails within thirty (30) days after receipt of such notice (a) to notify the Indemnified Party of its intent to defend, or (b) to defend, contest or otherwise protect against such suit, action,
investigation, claim or proceeding or fails to diligently continue to provide such defense after undertaking to do so, the Indemnified Party shall have the right upon ten (10) days prior written notice to the Indemnifying Party to defend,
settle and satisfy any such suit, action claim, investigation or proceeding and recover the costs of the same from the Indemnifying Party. 
  

	14.	TERMINATION 

 14.1 Termination. This
Agreement shall terminate upon the occurrence of any of the following events or conditions which termination shall automatically occur where termination by a specified party is not indicated and shall occur by action of the specified party where so
indicated: 
 (i) The expiration of the Initial Term or any Renewal Term; 
 (ii) The breach by either party of any provision of this Agreement which is not cured within thirty (30) days from the date of written notice
delivered to the defaulting party in the case of a payment default, and within ninety (90) days from the date of such notice in all other cases, unless such breach, not involving the payment of money, is of a nature that cannot be cured within
such ninety (90) day period and the breaching Party initiates the cure of such breach and proceeds diligently to remedy same provided, however, that only the aggrieved party can terminate this Agreement pursuant to this subsection (ii);

 (iii) The mutual written agreement of the parties to this Agreement; 
 (iv) The filing of a bankruptcy petition by or against a party or the appointment of a receiver for the assets or business of a party that is not
dismissed within sixty (60) days from the date of such filing or appointment; 
 (v) The continuation of any act of force majeure for a
period of six (6) months or longer; or 
 (vi) Election of either party upon two (2) years prior written notice to the other party,
given not earlier than the third anniversary of the FDA Approval of Finished Products. 
  

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 14.2 Termination by PLANTEX. This Agreement may be terminated by PLANTEX on the giving of
thirty-six (36) months prior written notice in the event that either: (i) a phase 3 Clinical Trial of a Finished Product has not been initiated on or before December 31, 2006 (or thereafter discontinued prior to successful
completion), or (ii) FDA approval of Finished Product shall not have been obtained by NOVACEA on or before December 31, 2011, provided, however, that after December 31, 2011, and until such time that FDA shall approve the Finished
Product, PLANTEX may not terminate this Agreement so long as NOVACEA or its licensee commits to a minimum purchase quantity of API of [*] grams or such amount necessary to cover the costs of manufacture of such API plus [*] percent, whichever is
greater. 
 14.3 Effect of Termination. Upon termination of this Agreement, all rights and obligations shall cease to exist except for
(i) the payment of unpaid invoices due, (ii) the recovery by a party hereto of damages caused by a breach of this Agreement by the other party, and (iii) the rights and obligations of the Parties which by their express terms survive
termination. 
  

	15.	FORCE MAJEURE  

 Except for the obligation of any
party to make payments to the other party pursuant to this Agreement (which shall not be deferred or extended for any reason), neither party to this Agreement shall be responsible to the other party for any failure to perform or delay in performing
if such failure or delay is due to any strike, riot, civil commotion, sabotage, embargo, war or act of God or other cause beyond its reasonable control. Neither party shall be responsible for any failure to perform or delay in performing due to
inability to obtain deliveries where such inability is caused by the supplier of such party; however, it shall not be an act of force majeure where PLANTEX, at the time it received the forecasts and purchase orders from NOVACEA, failed to make its
best efforts to ascertain the ability of its suppliers to make timely shipments to it, and to inform NOVACEA thereof, as required in this Agreement. 
  

	16.	CONFIDENTIALITY 

 16.1 Confidential
Information. In carrying out the terms of this Agreement it may be necessary that one party disclose to the other certain information, which is considered by the disclosing party to be proprietary and of a confidential nature. As used herein
“Confidential Information” shall mean any and all information, know-how and data, technical or non-technical concerning any finished drug product or bulk active pharmaceutical ingredient, its manufacture, marketing and sale, which
is disclosed under this Agreement as set forth below and which NOVACEA or PLANTEX, as the case may be, considers to be and treats as proprietary and confidential. Confidential Information shall include, but shall not be limited to plans, processes,
compositions, formulations, specifications, samples, systems, techniques, analyses, production and quality control data, testing data, marketing and financial data, and such other information or data relating to any finished drug product or bulk
active pharmaceutical ingredient or its manufacture, marketing or sale. 
  

	[*]	Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the
omitted portions. 

  

 -15- 

 16.2 Non-Use; Non-Disclosure. The receiving party shall not use the Confidential Information for
any purpose other than for purposes of performing its obligations under this Agreement and shall divulge the information only to those of its employees and consultants who have a need to know it as a part of the receiving party’s obligations
hereunder and said employees and consultants shall hold the information in confidence pursuant to this Agreement. The receiving party shall not disclose Confidential Information to any third party without the written consent of the disclosing party.

 16.3 Termination; Exceptions. The obligations of confidentiality as provided herein shall terminate ten (10) years from the
expiration or termination of this Agreement and shall impose no obligation upon the receiving party with respect to any portion of the received information which (i) was known to or in the possession of the receiving party prior to the
disclosure, and not through a prior disclosure by the disclosing party, as documented by business records; or (ii) is or becomes publicly known through no fault attributable to the receiving party; or (iii) is provided to the receiving
party from a source independent of the disclosing party which is not subject to a confidential or fiduciary relationship with the disclosing party concerning the information; or (iv) is developed by the receiving party independently of any
disclosure from the disclosing party and such independent development can be properly demonstrated by the receiving party; or (v) is required to be disclosed by law or court order, provided that notice is promptly delivered to the other party
in order to provide an opportunity to seek a protective order or other similar order with respect to the disclosure of such information and thereafter discloses only the minimum information required to be disclosed in order to comply with the
request, whether or not a protective order or other similar order is obtained by the other party. 
 16.4 Duties Upon Expiration or
Termination. Upon expiration or earlier termination of this Agreement, the receiving party shall, as the disclosing party may direct in writing, either destroy or return to the disclosing party all Confidential Information disclosed together
with all copies thereof, provided, however, the receiving party may retain one archival copy thereof for the purpose of determining any continuing obligations of confidentiality. 
 16.5 Survival. The terms of this Section 16 shall survive termination of this Agreement. 
  

	17.	GENERAL PROVISIONS  

 17.1 Successors and Assigns. (a) The terms and provisions hereof shall inure to the benefit of, and be binding upon, PLANTEX, NOVACEA and their respective successors and permitted assigns. Except as set
forth in subsection (b), below, neither Party may assign any of its rights or obligations under this Agreement without the prior written consent of the other. Any attempt to assign this Agreement in violation of the provisions set forth herein shall
be deemed a default by the assigning Party and null and void. It is hereby acknowledged that the manufacturer of the API is intended to be a third party beneficiary hereunder such that all representations and covenants of NOVACEA contained in this
Agreement shall also inure to the benefit of such manufacturer of API. Furthermore, NOVACEA may assign this Agreement to a Commercialization Partner with whom it enters into an agreement no later than December 31st, 2007 to commercialize the Finished Product. 
  

 -16- 

 (b) Either Party may assign this Agreement to an Affiliate of such Party upon prior written notice
thereof to the non-assigning Party. Such notice shall be accompanied by an undertaking, in form reasonably satisfactory to the non-assigning Party, assuring that the assigning Party shall not be released of any obligations and remain primarily
liable for the obligations of the assigning Party hereunder. Either Party may also assign this Agreement to a non-Affiliate upon prior written notice to the non-assigning Party in the event of a merger or acquisition of the assigning Party or the
sale by the assigning Party to such non-Affiliate of all or substantially all of the assets (including, without limitation, the NDA or ANDA for the Finished Products) to which this Agreement relates provided that such successor has assumed all
liabilities of the assigning Party hereunder. 
 17.2 Notices. Any notice, request, instruction or other communication required or
permitted to be given under this Agreement shall be in writing and shall be given by sending such notice properly addressed to the other party’s address shown below (or any other address as either party may indicate by notice in writing to the
other from time to time) (i) by hand or by prepaid registered or certified mail, return receipt requested, in either of such cases which notice shall be deemed delivered upon receipt, (ii) via telecopy, facsimile or telegram, in any of
such cases which notice shall be deemed delivered upon receipt, or (iii) via nationally recognized overnight courier, in which case such notice shall be deemed delivered upon receipt. All such notices shall be deemed given when received.

  

			
	If to PLANTEX:	    	PLANTEX USA Inc.
		    	2 University Plaza
		    	Suite 305
		    	Hackensack, New Jersey 07601
		    	Attention: President
		    	Fax Number: 1-201-343-3833
		
	If to NOVACEA:	    	NOVACEA, Inc.
		    	601 Gateway Blvd.
		    	Suite 800
		    	South San Francisco, CA 94080
		    	Attention: President
		    	Fax Number: 1-650-228-1088

 17.3 Publicity. Except to the extent required by law or deemed appropriate by legal counsel
to comply with securities laws, including the furnishing of a press release and the filing of such documents and information with the Securities and Exchange Commission as may be required by federal securities laws and the filing of any report,
statement or document required by any other federal or state regulatory body, neither party to this Agreement shall publish, disclose or otherwise announce the existence of this Agreement or the terms hereof with out the consent of the other party,
which consent shall not be unreasonably withheld. 
 17.4 Waiver. The failure of either party to terminate or seek redress for a
breach of, or to insist upon strict performance of any term, covenant, condition or provision contained in, this Agreement shall not prevent a similar subsequent act from constituting a breach of this Agreement. 
  

 -17- 

 17.5 Governing Law. This Agreement shall be governed and construed in accordance with the laws of
the State of New Jersey, without regard to principles of conflicts of law. 
 17.6 Counterparts. This Agreement may be executed in any
number of counterparts, each of which shall be an original as against either Party whose signature appears thereon, but all of which taken together shall constitute but one and the same instrument. 
 17.7 Independence of Parties. NOVACEA and PLANTEX shall at all times act as independent parties without the right or authority to bind the other
with respect to any agreement, representation or warranty made with or to any third party. Except as otherwise stated herein, NOVACEA and PLANTEX each shall be responsible for all costs, expenses, taxes and liabilities arising from the conduct of
its own business, as well as from the activities of its officers, directors, agents or employees, and each shall hold harmless and indemnify the other from any such obligations. 
 17.8 Entire Agreement. This Agreement contains the entire and only agreement between the parties with respect to the manufacture and sale of the
API and no oral statements or representations or written matter not contained in this Agreement shall have ally force or effect. This Agreement shall not be amended or modified in any way except by writing executed by authorized representatives of
both parties. 
 17.9 Partial Invalidity. If any portion of this Agreement is determined to be illegal or otherwise unenforceable by
agreement of the parties by an arbitrator, by a court of competent jurisdiction or by an administrative agency of competent jurisdiction, such section, to the extent permitted by law, shall be treated as deleted from this Agreement and the remaining
portions of this Agreement shall continue to be in full force and effect according to the terms hereof. 
 17.10 Headings. The
headings and captions used in this Agreement are for the convenience of reference only and shall not be construed as part of this Agreement or as a limitation on the scope of any provisions of this Agreement. 
 IN WITNESS WHEREOF, the parties hereto have set their hands and seals on the date written at the beginning hereof. 
  

									
	PLANTEX USA, INC.	 		 	NOVACEA, INC.
					
	By:	 	 /s/ George Svokos
	 		 	By:	 	 /s/ John Walker

	Name:	 	George Svokos	 		 	Name:	 	John Walker
	Title:	 	President	 		 	Title:	 	Chief Executive Officer
					
	By:	 	 /s/ Allen Lefkowitz
	 		 		 	
	Name:	 	Allen Lefkowitz	 		 		 	
	Title:	 	CFO	 		 		 	

  

 -18-

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