Document:

EX-4.4

 Exhibit 4.4 

DESCRIPTION OF SECURITIES REGISTERED UNDER SECTION 12 OF THE EXCHANGE ACT 

The following description of the common stock, $0.0001 par value per share (the “Common Stock”), of Karyopharm Therapeutics Inc.
(“us,” “our” or “we”), which is the only security of the Company registered under Section 12 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), summarizes certain information
regarding the Common Stock in our certificate of incorporation, our by-laws and applicable provisions of the Delaware General Corporation Law (the “DGCL”), and is qualified by reference to our
certificate of incorporation and by-laws, which are incorporated by reference as Exhibit 3.1 and Exhibit 3.2, respectively, to the Annual Report on Form 10-K of which
this Exhibit 4.4 is a part. 
 Authorized Capital Stock 

Our authorized capital stock consists of 200,000,000 shares of Common Stock and 5,000,000 shares of preferred stock, $0.0001 par value per
share (the “Preferred Stock”). 
 Common Stock 

Annual Meeting. Annual meetings of our stockholders are held on the date designated in accordance with our by-laws. Written notice must be mailed to each stockholder entitled to vote not less than ten nor more than 60 days before the date of the meeting. The presence in person or by proxy of the holders of record of a
majority of our issued and outstanding shares entitled to vote at such meeting constitutes a quorum for the transaction of business at meetings of the stockholders. Special meetings of the stockholders may be called for any purpose by the board of
directors, the chairman of the board or the chief executive officer. Except as may be otherwise provided by applicable law, our certificate of incorporation or our by-laws, all elections shall be decided by a
plurality, and all other questions shall be decided by a majority, of the votes cast by stockholders entitled to vote thereon at a duly held meeting of stockholders at which a quorum is present.  

Voting Rights. Each holder of Common Stock is entitled to one vote for each share held of record on all matters to be voted upon by
stockholders. 
 Dividends. Subject to the rights, powers and preferences of any outstanding Preferred Stock, and except as provided
by law or in our certificate of incorporation, dividends may be declared and paid or set aside for payment on the Common Stock out of legally available assets or funds when and as declared by the board of directors. 

Liquidation and Dissolution. Subject to the rights, powers and preferences of any outstanding Preferred Stock, in the event of our
liquidation or dissolution, our net assets will be distributed pro rata to the holders of our Common Stock. 
 Other Rights. Holders
of the Common Stock have no right to: 
  

	 	•	 	 convert the stock into any other security; 

 

	 	•	 	 have the stock redeemed; 

 

	 	•	 	 purchase additional stock; or 

 

	 	•	 	 maintain their proportionate ownership interest. 

The Common Stock does not have cumulative voting rights. The rights, preferences and privileges of the holders of Common Stock are subject to,
and may be adversely affected by, the rights of the holders of shares of any series of Preferred Stock that we may designate and issue. Holders of shares of the Common Stock are not required to make additional capital contributions. 

 Provisions of Our Certificate of Incorporation and By-laws and the
DGCL That May Have Anti-Takeover Effects 
 Board of Directors. Our certificate of incorporation and by-laws provide for a board of directors divided as nearly equally as possible into three classes. Each class is elected to a term expiring at the annual meeting of stockholders held in the third year following the
year of such election. The number of directors comprising our board of directors is fixed from time to time by the board of directors. 

Removal of Directors by Stockholders. Our certificate of incorporation and by-laws provide
that, subject to the rights of holders of any series of Preferred Stock, a member of our board of directors may only be removed for cause and only by an affirmative vote of the holders of at least 75% of the outstanding shares entitled to vote on
the election of the directors. 
 Super-Majority Voting. The DGCL provides generally that the affirmative vote of a majority of the
shares entitled to vote on any matter is required to amend a corporation’s certificate of incorporation or by-laws, unless a corporation’s certificate of incorporation or by-laws, as the case may be, requires a greater percentage. Subject to the rights of holders of any series of Preferred Stock, our by-laws may be amended or repealed by a
majority vote of our board of directors or the affirmative vote of the holders of at least 75% of the votes that all our stockholders would be entitled to cast in any annual election of directors. In addition, the affirmative vote of the holders of
at least 75% of the votes that all our stockholders would be entitled to cast in any annual election of directors is required to amend or repeal, or to adopt any provisions inconsistent with, any of the provisions of our certificate of incorporation
described under the prior two paragraphs. 
 Stockholder Nomination of Directors. Our by-laws
provide that a stockholder must notify us in writing of any stockholder nomination of a director not earlier than 120 days but not later than 90 days prior to the first anniversary of the preceding year’s annual meeting; provided, that if the
date of the annual meeting is advanced by more than 20 days, or delayed by more than 60 days, from such anniversary date, notice by the stockholder to be timely must be so delivered not earlier than the 120th day prior to the date of such annual meeting and not later than close of business on the later of (x) the 90th day prior to the date of such
meeting and (y) the 10th day following the day on which notice of the date of such annual meeting was mailed or public announcement of the date of such annual meeting is first made by us,
whichever occurs first. 
 No Action By Written Consent. Our certificate of incorporation and our
by-laws provide that our stockholders may not act by written consent and may only act at duly called meetings of stockholders. Our certificate of incorporation and our
by-laws also provide that, except as otherwise required by law, special meetings of our stockholders can only be called by our board of directors, chairman of the board or chief executive officer. In addition,
our by-laws establish an advance notice procedure for stockholder proposals to be brought before an annual meeting of stockholders, including proposed nominations of candidates for election to our board of
directors. 
 Delaware Business Combination Statute. We are subject to Section 203 of the DGCL. Subject to certain exceptions,
Section 203 prevents a publicly held Delaware corporation from engaging in a “business combination” with any “interested stockholder” for three years following the date that the person became an interested stockholder,
unless the interested stockholder attained such status with the approval of the corporation’s board of directors or unless the business combination is approved in a prescribed manner or the interested stockholder acquired at least 85% of the
corporation’s outstanding voting stock in the transaction in which it became an interested stockholder. A “business combination” includes, among other things, a merger or consolidation involving us and the “interested
stockholder” and the sale of more than 10% of our assets. In general, an “interested stockholder” is any entity or person beneficially owning 15% or more of our outstanding voting stock and any entity or person affiliated with or
controlling or controlled by such entity or person.pkg-ex413_182.htm

Exhibit 4.13

DESCRIPTION OF CAPITAL STOCK

PCA's certificate of incorporation authorizes the issuance of up to 300,000,000 shares of common stock, par value $0.01 per share and 3,000,000 shares of preferred stock, par value $0.01 per share.  As of December 31, 2019, 94,654,516 shares of common stock were issued and outstanding and no shares of preferred stock were outstanding.  All outstanding shares of common stock are duly authorized, validly issued, fully paid and non-assessable.

PCA's certificate of incorporation authorizes its board of directors, subject to any limitations prescribed by law, to issue shares of preferred stock in one or more series without stockholder approval. Each series of preferred stock will have the rights, preferences, privileges and restrictions, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences, as will be determined by the board of directors.  

Common Stock

Voting.  Each holder of common stock is entitled to one vote for each share on all matters to be voted upon by the stockholders and there are no cumulative voting rights. 

Dividends.  Subject to preferences to which any holders of preferred stock may be entitled, holders of common stock are entitled to receive ratably the dividends, if any, as may be declared from time to time by the board of directors out of funds legally available therefor.  

Liquidation.  If there is a liquidation, dissolution or winding up of PCA, holders of common stock would be entitled to share in PCA's assets remaining after the payment of liabilities and the satisfaction of any liquidation preference granted to the holders of any outstanding shares of preferred stock. 

Other Rights and Preferences.  Holders of common stock have no preemptive or conversion rights or other subscription rights and there are no redemption or sinking fund provisions applicable to the common stock. The rights, preferences and privileges of the holders of common stock are subject to, and may be adversely affected by the rights of the holders of shares of any series of preferred stock which the board of directors of PCA may designate in the future. 

Listing.  PCA’s common stock is listed on the New York Stock Exchange under the symbol “PKG.”

Certain Anti-Takeover Effects

PCA's certificate of incorporation and its bylaws may have the effect of making it more difficult for a third party to acquire, or of discouraging a third party from attempting to acquire, control of PCA. 

Advance Notice of Proposals and Nominations. PCA’s certificate of incorporation and bylaws provide for an advance notice procedure for stockholders to nominate persons to stand for election as a director or to bring other business before meetings of the stockholders. Any stockholder wishing to nominate persons to stand for election as a director or to bring other business before meetings must deliver advance written notice and certain other information to PCA’s Secretary in accordance with our bylaws. 

 Limits on Special Meetings. PCA’s certificate of incorporation and bylaws provide that special meetings of our stockholders may only be called by our board of directors or chief executive officer. 

 

 

Business transacted at any special meeting will be limited to the purposes specified in the notice calling such meeting.   Stockholders may not act by written consent. 

Preferred Stock. PCA’s board of directors is authorized to approve the issuance of one or more series of preferred stock without further authorization of our stockholders and to establish the rights, preferences, privileges and restrictions of the preferred stock, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences. As a result, our board of directors, without stockholder approval, could authorize the issuance of preferred stock with rights and preferences that could proportionately reduce, minimize or otherwise adversely affect the voting power and other rights of holders of common stock or other series of preferred stock or that could have the effect of delaying, deferring or preventing a change in our control.

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