Document:

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                                                                   EXHIBIT 10.12

                                   AGREEMENT

     This Agreement is entered into as of January 27, 2000, by and between IMX,
Inc., a California corporation ("IMX"), and CALYX TECHNOLOGY, INC. doing
business as Calyx Software, Incorporated, a California Corporation ("Calyx").
IMX and Calyx are sometimes hereinafter referred to individually as a "Party,"
or collectively as the "Parties."

                                  Background

     A.   IMX owns and operates an Internet-based exchange (the "IMX Exchange")
which uses proprietary software and on which (i) mortgage loan brokers
("Brokers") post mortgage loan applications for specific loan transactions, and
(ii) mortgage loan lenders ("Lenders") review the posted loan applications and
submit loan pricing proposal terms to the Broker, and (iii) the Brokers select
which Lender's pricing proposal to accept, and (iv) the Lenders pay an
"Exchange Fee" to IMX for loans placed from use of the IMX Exchange.

     B.   Calyx has developed and sells to Brokers and Lenders a computer
software titled Point(TM), which is used by Brokers and Lenders to prepare
mortgage loan applications (the "Calyx Mortgage Origination Software" or the
"Calyx Software").

     C.   IMX and Calyx wish to enter into this Agreement under which mortgage
loans that are originated by Brokers using Calyx Software can be seamlessly
posted on the IMX Exchange.

                                   Agreement

     Now, Therefore, in consideration of the foregoing and the mutual covenants
contained herein, the Parties agree as follows:

     1.   Strategic Alliance.
          ------------------

          1.1  Pursuant to the terms and conditions set forth in this Agreement,
IMX and Calyx hereby agree to enter into a strategic alliance pursuant to which
all mortgage loans that are originated by Brokers using the Calyx Mortgage
Origination Software, or its subsequent versions, can be seamlessly posted to
the IMX Exchange. Calyx will assist IMX in marketing the IMX Exchange to the
Calyx Broker users.

          1.2  The "Seamless Posting" functionality referenced in Section 1.1
means that (a) once a Broker using the Calyx Software has given the Broker's
one-time, up-front election to participate in the IMX Exchange feature of the
Calyx Software, then (b) for all subsequent loan applications prepared by that
Broker using the Calyx Software, the Broker will automatically resolve a "pop
up" screen when the Broker explicitly saves or closes a file if the minimum data
points (to be specified in Addendum A) for an IMX submission have been completed
for the first time or have been changed in the file, and (c) the Broker must
indicate "Yes" he wants the loan submitted to IMX Exchange or "No" he does not
want the loan submitted to IMX Exchange. From that point, the Calyx Software
will automatically post the loan information to IMX Exchange and the Broker will
be able to view any bids and lock loans through the Calyx Software. The methods
by which this is accomplished are described in Addendum A.

[*]= CERTAIN INFORMATION ON THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE COMMISSION.  CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO
THE OMITTED PORTIONS.
                                       1
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     2.   Consideration From IMX to Calyx.
          -------------------------------

          2.1  IMX will grant to Calyx a stock warrant to purchase [***] shares
of IMX Series D or E preferred stock, at an exercise price of $4.75 per share.
The warrant expires in ten years, but is subject to earlier termination upon a
sale, merger or IPO of IMX to the extent that Calyx does not elect to exercise
the warrant at that time. The warrant includes an "anti-dilution" provision
specifying adjustment of the warrant price and number of shares in certain
customary circumstances. A copy of the form of Stock Warrant is attached hereto.

          2.2  IMX will pay to Calyx a development fee of [***]. The first
installment of [***] will be paid upon signing of this Agreement. The second
installment of [***] will be paid when the interface described in 3.1 is
completed and released within the Calyx/Point software scheduled for March/April
of 2000.

          2.3  IMX will pay to Calyx a bonus of [***] if and only if a total of
[***] Point Broker companies become IMX members and which total will include any
Point users which currently are IMX members), within 12 months from the release
of the interface in Calyx Software.

     3.   Responsibilities.
          ----------------

          3.1  IMX and Calyx will jointly develop the necessary interface to
facilitate the seamless export to the IMX Exchange of the loan application data
from the participating Brokers who use the Calyx Software and elect to post
loans on the IMX Exchange. The interface specifications and programming
responsibilities of both parties are attached in Addendum A. Payment of the sums
set forth in Section 2.2 is not conditioned upon completion of components or
content by IMX. Calyx agrees to distribute the latest IMX components in
Calyx/POINT product releases according to standard manufacturing schedules.

          3.2  Calyx will cooperate and assist IMX in marketing the IMX Exchange
to Calyx's Broker customers by providing access to customers through Calyx. Each
party shall provide copies of all marketing materials 15 days in advance of the
release thereof. The release of marketing materials requires approval of both
parties. Any objection to marketing materials must be made in writing to the
other party within 15 days of receipt and must set forth the reason for
rejecting the proposed marketing material. Failure to object within the 15 day
period shall be deemed as approval. The specific marketing plan is attached in
Addendum B.

          3.3  IMX and Calyx will each provide customary and appropriate
technical support and updates to its own software, in order to best facilitate
(a) the interface between the Calyx Software and the IMX Exchange, and (b) the
Brokers' use of the same.

     4.   Term.  The initial term of this strategic alliance shall be 24 months
          ----
from the signing of this Agreement. The "Seamless Posting" functionality and the
"Default Selection" in the vendor installation screen will be exclusive to IMX
Exchange for the period beginning with the signing of this Agreement through the
next major release (version 3.7/4.0), or September 1/st/, 2000 whichever comes
later. Therefore, if Calyx makes the "Default Selection" available in the future
to any vendor, IMX will have the right to pay the marketing fee to continue its
exclusive default setting or have a rolling default among other vendors if more
than one vendor wished to pay the marketing fee. The "Notification"
functionality and the "Rich Content" in the vendor installation screen will be
available only to IMX when they are first release within the

[*]= CERTAIN INFORMATION ON THIS PAGE HAS BEEN OMITTED AND FILED SEPARATELY WITH
THE COMMISSION.  CONFIDENTIAL TREATMENTS HAS BEEN REQUESTED WITH RESPECT TO THE
OMITTED PORTIONS.
                                       2

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Calyx/POINT software scheduled for March/April of 2000. Calyx agrees not to
openly market these enhancements until the next major release or September
/1st/, 2000, whichever comes later. The term shall be renewed for a successive
12-month term upon signature of a new agreement. The term of this strategic
alliance may be earlier terminated by a Party due to the material default of the
other Party, if such default is not cured within 30 days after written notice of
the default is given to the defaulting Party.

     5.   Confidentiality and Intellectual Property Rights.
          ------------------------------------------------

          5.1  Each Party hereby agrees to maintain the confidentiality of the
other Party's confidential information and proprietary information, and each
Party hereby agrees to not use the other Party's confidential information and
proprietary information other than as is expressly contemplated by this
Agreement.

          5.2  Each party agrees that all information communicated to the other
with respect to the proposed Software, including any confidential information
relating to the proposed Software gained by either party or their personnel,
whether or not that information was directly or intentionally communicated, is
confidential.

          5.3  Each party promises and agrees that it shall not disclose any
confidential information to any other person unless specifically authorized in
writing to do so. If either party gives the other written authorization to make
any disclosures, it shall do so only within the limits and to the extent of that
authorization. The confidentiality, non-disclosure and non-use obligations of
this Section 5 shall not apply to information which the recipient demonstrates:

               (a)  is known to it prior to receipt from the other party,
provided the recipient promptly notifies the other party of such prior knowledge
and supplies the other party with written evidence to support such prior
knowledge; or

               (b)  is or becomes part of the public domain through no act by or
on behalf of recipient; or

               (c)  was lawfully received by the recipient from a third party
having a right to disclose it to the recipient; or

               (d)  was developed by or for the recipient totally independent of
the disclosure hereunder, and without any assistance from the disclosure
hereunder, as evidenced by recipient's written records.

          5.4  Each party shall use its diligent efforts to prevent inadvertent
disclosure of any confidential information to any third party. Each party shall
instruct its personnel to keep that information confidential by using the same
care and discretion that they use with similar data designated as confidential.

          5.5  Without limiting the generality of the foregoing, each Party
hereby agrees that it will not attempt to decompile, decipher, disassemble,
reverse engineer or decrypt the source code or other proprietary features of the
other Party's software or other intellectual property.

                                       3
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          5.6  Each Party shall retain full and sole ownership of its own
intellectual property rights, particularly including its own software and all
improvements and enhancements, and all copyrights and all trade secrets.
Excepting only for and to the extent necessary for implementing the transactions
and activities specified in this Agreement, no license rights are granted by
either Party to the other Party for use of any intellectual property rights.

          5.7  With respect to the development by IMX of the Unique Linkage
Specifications, IMX shall retain sole ownership thereof; and Calyx shall be
entitled to use the same only for the performance of this Agreement with IMX.
IMX and Calyx agree that all original material, including all computer programs
and all related printed material comprising the Software originated and prepared
by Calyx pursuant to this Agreement, shall belong exclusively to Calyx and shall
constitute a trade secret owned by Calyx. IMX acknowledges and agrees that the
unauthorized use or disclosure of confidential information concerning the
Software is prohibited. Calyx shall have the exclusive right to protect the
Software by copyright or any other means. However, Calyx agrees that upon
payment in full pursuant to the terms of the agreement, Calyx will convey to IMX
an exclusive non-assignable (except as permitted by Section 10.7 hereof) license
for the use of the Software by IMX.

          5.8  IMX hereby authorizes Calyx to post the IMX trademarks on the
Calyx Software for purposes of implementing this Agreement, all in accordance
with specifications to be mutually approved by both Parties. Similarly, Calyx
hereby authorizes IMX to post Calyx trademarks on the IMX Exchange for purposes
of implementing this Agreement, all in accordance with specifications to be
mutually approved by both Parties.

          5.9  Each Party shall be entitled to include on its internet web site
one or more links and/or icons to the other Party's internet web site, but in
each instance, subject to the prior review and reasonable approval as to the
specifications for such matters.

     6.   Press Release. The Parties will consult with each other with regard to
          -------------
the terms and substance of any and all press releases, announcements or other
public statements with respect to the transactions contemplated hereby. The
Parties further agree that no Party will release any such press release,
announcement or other public statement without the prior approval of the other
Party, unless such release is required by law and the Parties cannot approve a
mutually acceptable form of release.

     7.   Expenses. Except as otherwise set forth in this Agreement, each Party
          --------
shall bear its own costs and expenses associated with the transactions
contemplated. IMX will produce all collateral material at its cost and Calyx
will pay for all distribution costs.

     8.   Most Favored Client. Pursuant to Section 4 hereof, during the
          -------------------
Exclusive Period, Calyx is not to enter into other agreements with other parties
for automatic posting of mortgage loan applications. After the Exclusive Period,
in the event Calyx enters into an agreement with another party that offers
automatic posting generally as described in the specifications attached to this
Agreement, if such other agreement is materially more advantageous to such other
party than the automatic posting capabilities described herein extended to IMX
Exchange, Calyx will extend the same features or capabilities for the IMX
Exchange.

                                       4
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     9.   Warranties and Limitations on Liability.
          ---------------------------------------

          9.1  Each Party hereby represents and warrants that:

               (a)  All work to performed in connection with the development,
update, support and maintenance of its software, and other services performed
under this Agreement shall be performed in a prompt, professional and
workmanlike manner.

               (b)  Its software shall be free of defects in material and
workmanship.

               (c)  Each Party will be solely responsible for its own software
and its own operations, and the other Party shall not have any responsibilities
or liabilities therefor.

               (d)  Each Party has full power to enter into and perform this
Agreement, and the person signing this Agreement on its behalf has been duly
authorized and empowered to enter into this Agreement.

               (e)  This Agreement does not, and shall not, violate any other
agreement of such Party with a third party.

          9.2  EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT, NEITHER PARTY
MAKES ANY WARRANTIES IN CONNECTION WITH THE SUBJECT MATTER OF THIS AGREEMENT,
AND EACH PARTY HEREBY DISCLAIMS ANY AND ALL OTHER WARRANTIES, EXPRESS OR
IMPLIED, INCLUDING WITHOUT LIMITATION, ANY IMPLIED WARRANTY OF NON-INFRINGEMENT
OF THIRD PARTY RIGHTS, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.
NEITHER PARTY WARRANTS THAT ITS SOFTWARE OR WEB SITE WILL OPERATE ERROR-FREE OR
WITHOUT INTERRUPTION.

          9.3  EXCEPT FOR LIABILITY RESULTING FROM FRAUD, GROSS NEGLIGENCE,
INTENTIONAL MISCONDUCT, BREACH OF CONFIDENTIALITY, OR MISAPPROPRIATION OF
INTELLECTUAL PROPERTY RIGHTS, IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE
OTHER PARTY FOR ANY SPECIAL, INCIDENTAL, CONSEQUENTIAL OR PUNITIVE DAMAGES
ARISING OUT OF THIS AGREEMENT OR ITS TERMINATION, WHETHER LIABILITY IS ASSERTED
IN CONTRACT, TORT (INCLUDING NEGLIGENCE) OR OTHERWISE, AND IRRESPECTIVE OF
WHETHER SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF ANY SUCH LOSS OR
DAMAGE.

     10.  General.
          -------

          10.1 IMX and Calyx agree that they shall perform their duties under
this Agreement as independent contractors. Personnel employed by IMX or Calyx
who perform duties related to this Agreement shall remain under the supervision,
management or contract of the company by who they are paid.

          10.2 This Agreement is governed by California law without regard to
the conflicts of laws principles.

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          10.3  In the event of invalidity of any provisions of this Agreement,
the Parties agree that such invalidity shall not affect the validity of the
remaining portions of this Agreement.

          10.4  This Agreement completely and exclusively states the agreement
of the Parties regarding the subject matter, and this Agreement supersedes, and
its terms govern, all prior proposals and agreements, oral or written, regarding
such subject matter, with the exception of any nondisclosure and/or
confidentiality agreements currently in effect among the Parties.

          10.5  This Agreement may be changed only by written agreement of
authorized representatives of the Parties.

          10.6  The Parties hereto are independent contractors. Nothing
contained herein or done in pursuance of this Agreement shall constitute either
Party the agent of the other Party for any purpose or in any sense whatsoever,
or constitute the Parties as partners or joint ventures.

          10.7  This Agreement shall be binding upon and inure to the benefit of
the Parties hereto and their respective successors and assigns. Neither Party
may assign any of its rights, obligations or privileges (by operation of law or
otherwise) hereunder without the prior written consent of the other Party, which
consent shall not be unreasonably withheld; provided, however, that either Party
shall have the right to assign its rights, obligations and privileges hereunder
without obtaining any consent to such assignment from the other Party in the
event of a merger, acquisition or sale of all or substantially all of that
Party's business or assets in which the acquiring Party agrees to assume all
such rights, obligations and privileges hereunder.

          10.8  Any notice required or permitted to be given by either Party
under this Agreement shall be in writing and shall be delivered personally, or
by telecopy, or by U.S. mail, or by a nationally recognized overnight delivery
service, to the other Party at its address first set forth above, or such new
address as may from time to time be supplied hereunder by the Parties hereto.

          10.9  Except for the payment of money, no default, delay or failure to
perform on the part of either Party shall be considered a breach of this
Agreement if such default, delay or failure to perform is shown to be due to
causes beyond the reasonable control of the Party charged with a default,
including, but not limited to, causes such as riots, civil disturbances, actions
or inaction's of governmental authorities or suppliers, epidemics, war,
embargoes, severe weather, fire, earthquakes, acts of nature or the public
enemy, nuclear disasters, or default of a common carrier; provided, however,
that for the duration of such force majeure the Party charged with such default
must continue to use all reasonable efforts to overcome such force majeure.

IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be
executed as of the date set forth above.

IMX, Inc.                                    Calyx Software, Incorporated

By:   /s/ Richard Wilkes                     By:  /s/ Dong Chang
    -------------------------------             -------------------------------
Print Name: Richard E Wilkes                 Print Name:  Dong Chang
           ------------------------                      ----------------------
Title:    President                          Title:   President
       ----------------------------                 ---------------------------<PAGE>

                                                                   EXHIBIT 10.23

LETTER OF UNDERSTANDING

February 26, 2000

Lucy Day
Chief Financial Officer
Centaur Pharmaceuticals, Inc.
484 Oakmead Parkway
Sunnyvale, CA 94086

Dear Ms. Day:

This letter is to confirm our understanding (the "Understanding")
that Centaur Pharmaceuticals, Inc. ("Centaur" or the "Company") desires
eMedsecurities, Inc. ("EMED") to act as a selling agent ("Selling Agent") in an
offering of the Company's securities (the "Offering") which is being lead
managed by Bank Vontobel AG ("Bank Vontobel" or the "Underwriter").

1.  As Selling Agent EMED will execute a separate selling agent agreement with
    Bank Vontobel regarding the Offering (the "Selected Dealers Agreement"). It
    is understood that Centaur will provide EMED with a list of individuals
    and/or institutions residing within the United States whom Centaur has
    previously contacted regarding an investment in the Company (the "Potential
    Investors"). EMED will contact the Potential Investors designated by Centaur
    and in the event Potential Investors are interested in participating in the
    Offering, EMED will assist in facilitating the transaction. EMED will also
    contact additional domestic institutional investors with the intention of
    including them in the Company's domestic road show.

2.  For acting as Selling Agent Centaur assures that EMED will receive a minimum
    of $50,000 from its Selling Concession as described in the Selected Dealers
    Agreement between Bank Vontobel AG and EMED in the event that the offering
    is successful at its target amount of $12,420,000 (the "Target Amount"). If
    the gross proceeds of the offering are equal to or are more than the Target
    Amount and EMED's Selling Concession is less than $50,000, Centaur agrees to
    pay the differential to reach $50,000. If the offering is smaller in value
    the minimum EMED will receive will be prorated. In the event that the
    offering is not consummated due to lack of interest EMED will receive
    $7,500.

3.  It is Centaur's intention to accept all qualified orders in the Offering.

4.  In connection with EMED's activities on the Company's behalf, Centaur will
    furnish EMED with all information which it may reasonably request and will
    provide EMED access to the officers, directors, accountants and counsel of
    Centaur. Centaur and EMED agree that in rendering its services hereunder,
    EMED shall be solely using and relying on the information provided by the
    Company as well as publicly available information in discussing the Company.
    EMED does not assume responsibility for the accuracy or completeness of any
    information provided by the Company or its advisors. Any advice rendered by
    EMED pursuant to this agreement may not be disclosed publicly without its
    prior written consent.
<PAGE>

5.  In addition to any fees that may be payable to EMED hereunder (and
    regardless of whether the Offering occurs), the Company hereby agrees to
    reimburse EMED for all reasonable and necessary travel and other out of
    pocket expenses incurred in performing its services hereunder, including the
    reasonable fees and expenses of its legal counsel incurred as a direct
    result of EMED performing its duties hereunder, but excluding any standard
    costs of registering as a broker or dealer under the laws of any
    jurisdiction. Such expense shall be submitted on a monthly basis and
    reimbursed upon receipt. All expenses will be capped at five thousand
    dollars ($5,000) and any expenses thereafter will be first approved by
    Centaur.

6.  The Company agrees that following the offering, EMED has the right to place
    advertisements in financial and other newspapers and journals describing its
    services to the Company hereunder upon review and approval by the Company
    whose approval should not be unreasonably withheld.

7.  EMED will act under this letter agreement as an independent contractor with
    duties to the Company. Because EMED will be acting on the' Company's behalf
    in this capacity, it is EMED's practice to receive indemnification. A copy
    of EMED's standard indemnification form is attached to this letter.

8.  EMED and CENTAUR mutually agree that they will not disclose any confidential
    information received from the other party to others except with the written
    permission of the other party or as such disclosure may be required by law.

9.  This Understanding shall be governed by and construed in accordance with the
    laws of the State of New York applicable to contracts executed in and to be
    performed in that state.

If you believe this letter represents our mutual understanding, kindly sign and
date the enclosed copy of this letter and indemnification form and return it to
us.

Very truly yours,

eMedsecurities, Inc.

By:    /s/ Robert W. Naismith, Ph.D.
     -------------------------------
     Robert W. Naismith, Ph.D.
     CEO and Chairman

ACCEPTED AND AGREED TO as of the date hereof    2/26/99
                                             ------------

Centaur Pharmaceuticals

By:    /s/ Lucy Day
     -----------------------
     Lucy Day
     Chief Financial Officer

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