Document:

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                          REGISTRATION RIGHTS AGREEMENT

      THIS REGISTRATION RIGHTS AGREEMENT (this "Agreement") is made as of the
_____ day of ______________, 2005, by and between AHPC HOLDINGS, INC., a
Maryland corporation (the "Company"), and each of the investors listed on
Schedule A hereto (collectively, the "Investors" and each an "Investor"), each
of whom is a holder of shares of the Company's Series A Convertible Preferred
Stock (the "Preferred Shares").

      WHEREAS, the Company and the holders of the Preferred Shares are parties
to various certain subscription agreements, relating to the purchase of the
Preferred Shares (the "Subscription Agreements");

      WHEREAS, the Subscription Agreements entitle the Investors to convert the
Preferred Shares into the Company's common stock (the "Common Stock") on a
on-for-one basis at any time following the closing of the purchase and sale of
the Preferred Shares, subject to additional terms and conditions as set forth in
the Certificate of Designations and Preferences related to the Preferred Shares;

      WHEREAS, as a partial inducement to the Investors to purchase the
Preferred Shares, the Investors and the Company hereby agree that this Agreement
shall govern the rights of the Investors with respect to the registration of
shares of Common Stock issuable to the Investors upon the conversion of the
Preferred Shares into Common Stock.

      NOW, THEREFORE, the parties hereby agree as follows:

      1.    Registration Rights. The Company covenants and agrees as follows:

            1.1 Definitions. For purposes of this Section 1:

                  (a) The term "Act" means the Securities Act of 1933, as
      amended.

                  (b) The term "Holder" means any person owning or having the
      right to acquire Registrable Securities or any assignee thereof in
      accordance with Section 1.8 hereof.

                  (c) The term "1934 Act" means the Securities Exchange Act of
      1934, as amended.

                  (d) The terms "register," "registered," and "registration"
      refer to a registration effected by preparing and filings a registration
      statement or similar document in compliance with the Act, and the
      declaration or ordering of effectiveness of such registration statement or
      document.

                  (e) The term "Registrable Securities" means:

                        (i) the Common Stock issuable or issued upon conversion
            of the Preferred Shares;

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                        (ii) the Common Stock issuable or issued to LaSalle St.
            Securities, LLC ("LaSalle") in connection with its services as a
            placement agent for the Preferred Shares (on an as converted basis
            to the extent such services were provided for Preferred Shares); and

                        (iii) any Common Stock issued as (or issuable upon the
            conversion or exercise of any warrant, right or other security that
            is issued as) a dividend, penalty for non-registration or other
            distribution with respect to, or in exchange for, or in replacement
            of, the shares referenced in Section 1.1(f)(i) and (ii) above,
            excluding in all cases, however, any Registrable Securities sold by
            a person in a transaction in which his rights under this Section 1
            are not assigned.

                  (f) Except as provided in Section 1.1(f) above, the number of
      shares of "Registrable Securities" outstanding shall be determined by the
      number of shares of Common Stock outstanding that are, and the number of
      shares of Common Stock issuable pursuant to then-exercisable or
      convertible securities that are, Registrable Securities.

                  (g) The term "SEC" shall mean the Securities and Exchange
      Commission.

            1.2 Registration of the Preferred Shares. No later than sixty (60)
days following the closing of the purchase and sale of the Preferred Shares, the
Company shall file a registration statement with the SEC relating to the resale
of the Registrable Securities and use commercially reasonable efforts to have
the SEC declare such registration statement effective and to effect any related
qualification or compliance with respect to the Registrable Securities as soon
as possible, but in no event later than 180 days from the closing of the
purchase and sale of the Preferred Shares.

            1.3 Penalty for Non-Registration. The Company has agreed that it
shall pay the Holders a penalty if the Company fails to comply with the
deadlines set forth in Section 1.2. For each violation of either the failure to
file a registration statement (a "60-Day Violation") or have the registration
statement declared effective (a "180-Day Violation"), the Company shall issue
the Holders a 3-year warrant ("Penalty Warrants") to purchase ten percent (20%)
of the number of Common Shares into which their Preferred Shares are convertible
as of the date of issuance, exercisable at a per share price equal to the
closing price of the Company's Common Stock on the business day immediately
preceding the date of initial issuance of the Preferred Shares, and having such
other terms and conditions reasonably agreeable to LaSalle and the Company. If
the Company commits either a 60-Day Violation or a 180-Day Violation, the
Company shall have an additional 30-day period (as the case may be) in which to
comply. Subsequent 60-Day or 180-Day Violations will compel the Company to issue
to the Holders additional Penalty Warrants of like amount as set forth above for
each applicable 30-day period.

            1.4 Obligations of the Company. Whenever required under this Section
1 to effect the registration of any Registrable Securities, the Company shall,
as expeditiously as reasonably possible:

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                  (a) In connection with the registration statement filed
      pursuant to Section 1.2, the Company will keep such registration effective
      until the earlier of:

                        (i) three (3) years from the effective date of the
            filing of such registration statement;

                        (ii) the date on which all of the Holders have completed
            the distribution described in such registration statement; or

                        (iii) when all Holders will be eligible to dispose of
            their remaining eligible securities over a period of no greater than
            two calendar quarters pursuant to Rule 144.

                  (b) In connection with the registration statement filed
      pursuant to Section 1.2, the Company will prepare and file with the SEC
      such amendments and supplements to such registration statement and the
      prospectus used in connection therewith as may be necessary to comply with
      the provisions of the Securities Act with respect to the disposition of
      the Registrable Securities.

                  (c) In connection with the registration statement filed
      pursuant to Section 1.2, the Company shall furnish to the Holders such
      number of prospectuses related thereto as the Holders shall reasonably
      request.

                  (d) If, after the registration statement described in Section
      1.2 becomes effective, the Company advises the Holders that:

                        (i) the Company considers it appropriate for the
            registration statement to be amended, the Holders shall suspend any
            further sales of Registrable Securities until the Company advises
            the Holders that the registration statement has been amended; or

                        (ii) the Company is no longer eligible to continue the
            registration of the Registrable Securities on Form S-3 or such other
            form as the Registrable Securities shall have been registered, then
            the Holders agree to suspend sales of their Registrable Securities
            (except to the extent otherwise legally permitted) until the Company
            shall have effected new registration of their Registrable Securities
            in accordance with Form SB-2, Form S-1 or as otherwise permitted by
            applicable law.

                  (e) The Company shall pay all costs, fees and expenses in
      connection with the registration statement filed pursuant to Section 1.2
      (excluding fees and expenses of the Holders' counsel and underwriting
      discounts or selling commissions and transfer, income and other taxes
      applicable to the Registrable Securities), including, without limitation,
      the Company's legal and accounting fees, printing expenses and blue sky
      fees and expenses.

                  (f) The Company will take all necessary action which may be
      required in qualifying or registering the Registrable Securities included
      in a registration statement

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      described in Section 1.2 for offering and sale under the securities or
      blue sky laws of such states as may be reasonably requested by the
      Holders.

                  (g) Notwithstanding the foregoing provisions of this Section
      1.3, no registration rights shall be extended pursuant to this Section 1
      with respect to any Registrable Securities:

                        (i) which have been sold pursuant to and in accordance
            with an effective registration statement;

                        (ii) sold in accordance with Rule 144 under the Act; or

                        (iii) sold in a private transaction in which the
            Holder's rights hereunder are not assigned.

            1.5 Information from Holders. It shall be a condition precedent to
the obligations of the Company to take any action pursuant to this Section 1
with respect to the Registrable Securities of any selling Holder that such
Holder shall furnish to the Company such information regarding itself, the
Registrable Securities held by it, and the intended method of disposition of
such securities as shall be required to effect the registration of such Holder's
Registrable Securities.

            1.6 Delay of Registration. No Holder shall have any right to obtain
or seek an injunction restraining or otherwise delaying any such registration as
the result of any controversy that might arise with respect to the
interpretation or implementation of this Section 1.

            1.7 Indemnification.

                  (a) To the extent permitted by law, the Company will indemnify
      and hold harmless each Holder, the partners or officers, directors and
      stockholders of each Holder, legal counsel and accountants for each
      Holder, any underwriter (as defined in the Act) for such Holder and each
      person, if any, who controls such Holder or underwriter within the meaning
      of the Act or the 1934 Act, against any losses, claims, damages or
      liabilities (joint or several) to which they may become subject under the
      Act, the 1934 Act or any state securities laws, insofar as such losses,
      claims, damages, or liabilities (or actions in respect thereof) arise out
      of or are based upon any of the following statements, omissions or
      violations (collectively a "Violation") by the Company:

                        (i) any untrue statement or alleged untrue statement of
            a material fact contained in such registration statement, including
            any preliminary prospectus or final prospectus contained therein or
            any amendments or supplements thereto;

                        (ii) the omission or alleged omission to state therein a
            material fact required to be stated therein, or necessary to make
            the statements therein not misleading; or

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                        (iii) any violation or alleged violation by the Company
            of the Act, the 1934 Act, any state securities laws or any rule or
            regulation promulgated under the Act, the 1934 Act or any state
            securities laws;

      and the Company will reimburse each such Holder, underwriter or
      controlling person for any legal or other expenses reasonably incurred by
      them in connection with investigating or defending any such loss, claim,
      damage, liability or action; provided, however, that the indemnity
      agreement contained in this Section 1.7(a) shall not apply to amounts paid
      in settlement of any such loss, claim, damage, liability or action if such
      settlement is effected without the consent of the Company (which consent
      shall not be unreasonably withheld), nor shall the Company be liable in
      any such case for any such loss, claim, damage, liability or action to the
      extent that it arises out of or is based upon a Violation that occurs in
      reliance upon and in conformity with written information furnished
      expressly for use in connection with such registration by any such Holder,
      underwriter or controlling person; provided further, however, that the
      foregoing indemnity agreement with respect to any preliminary prospectus
      shall not inure to the benefit of any Holder or underwriter, or any person
      controlling such Holder or underwriter, from whom the person asserting any
      such losses, claims, damages or liabilities purchased shares in the
      offering, if a copy of the prospectus (as then amended or supplemented if
      the Company shall have furnished any amendments or supplements thereto)
      was not sent or given by or on behalf of such Holder or underwriter to
      such person, if required by law so to have been delivered, at or prior to
      the written confirmation of the sale of the shares to such person, and if
      the prospectus (as so amended or supplemented) would have cured the defect
      giving rise to such loss, claim, damage or liability.

                  (b) To the extent permitted by law, each selling Holder will
      indemnify and hold harmless the Company, each of its directors, each of
      its officers who has signed the registration statement, each person, if
      any, who controls the Company within the meaning of the Act, legal counsel
      and accountants for the Company, any underwriter, any other Holder selling
      securities in such registration statement and any controlling person of
      any such underwriter or other Holder, against any losses, claims, damages
      or liabilities (joint or several) to which any of the foregoing persons
      may become subject, under the Act, the 1934 Act or any state securities
      laws, insofar as such losses, claims, damages or liabilities (or actions
      in respect thereto) arise out of or are based upon any Violation, in each
      case to the extent (and only to the extent) that such Violation occurs in
      reliance upon and in conformity with written information furnished by such
      Holder expressly for use in connection with such registration; and each
      such Holder will reimburse any person intended to be indemnified pursuant
      to this Section 1.7(b), for any legal or other expenses reasonably
      incurred by such person in connection with investigating or defending any
      such loss, claim, damage, liability or action; provided, however, that the
      indemnity agreement contained in this Section 1.7(b) shall not apply to
      amounts paid in settlement of any such loss, claim, damage, liability or
      action if such settlement is effected without the consent of the Holder
      (which consent shall not be unreasonably withheld), provided that in no
      event shall any indemnity under this Section 1.7(b) exceed the gross
      proceeds from the offering received by such Holder.

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                  (c) Promptly after receipt by an indemnified party under this
      Section 1.7 of notice of the commencement of any action (including any
      governmental action), such indemnified party will, if a claim in respect
      thereof is to be made against any indemnifying party under this Section
      1.7, deliver to the indemnifying party a written notice of the
      commencement thereof and the indemnifying party shall have the right to
      participate in, and, to the extent the indemnifying party so desires,
      jointly with any other indemnifying party similarly noticed, to assume the
      defense thereof with counsel reasonably satisfactory to each party;
      provided, however, that an indemnified party (together with all other
      indemnified parties that may be represented without conflict by one
      counsel) shall have the right to retain one separate counsel, with the
      fees and expenses to be paid by the indemnifying party, if representation
      of such indemnified party by the counsel retained by the indemnifying
      party would be inappropriate due to actual or potential differing
      interests between such indemnified party and any other party represented
      by such counsel in such proceeding. The failure to deliver written notice
      to the indemnifying party within a reasonable time of the commencement of
      any such action, if prejudicial to its ability to defend such action,
      shall relieve such indemnifying party of any liability to the indemnified
      party under this Section 1.7, but the omission so to deliver written
      notice to the indemnifying party will not relieve it of any liability that
      it may have to any indemnified party otherwise than under this Section
      1.7. After notice from an indemnifying party to such indemnified party of
      its election to assume the defense thereof, the indemnifying party will
      not be liable to such indemnified party pursuant to the provisions of this
      Section 1.7 for any legal or other expense subsequently incurred by such
      indemnified party in connection with the defense thereof other than
      reasonable costs of investigation, unless:

                        (i) the indemnified party shall have employed counsel in
            accordance with the first sentence of this Section 1.7(c);

                        (ii) the indemnifying party shall not have employed
            counsel satisfactory to the indemnified party to represent the
            indemnified party within a reasonable time after the notice of the
            commencement of the action; or

                        (iii) the indemnifying party has authorized the
            employment of counsel for the indemnified party at the expense of
            the indemnifying party.

                  (d) If the indemnification provided for in this Section 1.7 is
      held by a court of competent jurisdiction to be unavailable to an
      indemnified party with respect to any loss, liability, claim, damage or
      expense referred to herein, then the indemnifying party, in lieu of
      indemnifying such indemnified party hereunder, shall contribute to the
      amount paid or payable by such indemnified party as a result of such loss,
      liability, claim, damage or expense in such proportion as is appropriate
      to reflect the relative fault of the indemnifying party on the one hand
      and of the indemnified party on the other in connection with the
      statements or omissions that resulted in such loss, liability, claim,
      damage or expense, as well as any other relevant equitable considerations.
      The relative fault of the indemnifying party and of the indemnified party
      shall be determined by reference to, among other things, whether the
      untrue or alleged untrue statement of a material fact or the omission to
      state a material fact relates to information supplied by the

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      indemnifying party or by the indemnified party and the parties' relative
      intent, knowledge, access to information, and opportunity to correct or
      prevent such statement or omission; provided, however, that in no event
      shall any contribution by any Holder hereunder exceed the net proceeds
      from the offering received by such Holder.

                  (e) The obligations of the Company and Holders under this
      Section 1.7 shall survive the completion of any offering of Registrable
      Securities in a registration statement under this Section 1, and
      otherwise.

            1.8 Assignment of Registration Rights. The rights to cause the
Company to register Registrable Securities pursuant to this Section 1 may be
assigned (with all related obligations) by a Holder of such securities to a
transferee or assignee of the Registrable Securities which:

                  (a) is a subsidiary, parent, general partner, limited partner,
      retired partner, member or retired member of such Holder; or

                  (b) is such Holder's family member or trust for the benefit of
      such Holder, provided:

                        (i) the Company is, within ten (10) days after such
            transfer, furnished with written notice of the name and address of
            such transferee or assignee and the securities with respect to which
            such registration rights are being assigned; and

                        (ii) such transferee or assignee agrees in writing to be
            bound by and subject to the terms and conditions of this Agreement.

      2.    Miscellaneous.

            2.1 Successors and Assigns. Except as otherwise provided herein, the
terms and conditions of this Agreement shall inure to the benefit of and be
binding upon the respective successors and assigns of the parties (including
transferees of any shares of Registrable Securities). Nothing in this Agreement,
express or implied, is intended to confer upon any party other than the parties
hereto or their respective successors and assigns any rights, remedies,
obligations, or liabilities under or by reason of this Agreement, except as
expressly provided in this Agreement.

            2.2 Governing Law. This Agreement shall be governed by and construed
under the laws of the State of Illinois as applied to agreements between
Maryland residents entered into and to be performed entirely within Illinois.
Any dispute with respect to the subject matter of this Agreement shall be
determined by arbitration in Cook County, Illinois, in accordance with the rules
of the American Arbitration Association ("AAA") and determined by an AAA
arbitrator selected in accordance with the AAA rules, with each party to bear
his, her or its respective costs and fees in such proceeding with the
complainant, on the one hand, and defendant(s), on the other hand, to bear
equally the cost of the AAA arbitrator.

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            2.3 Counterparts. This Agreement may be executed in two (2) or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

            2.4 Titles and Subtitles. The titles and subtitles used in this
Agreement are used for convenience only and are not to be considered in
construing or interpreting this Agreement.

            2.5 Notices. Unless otherwise provided, any notice required or
permitted under this Agreement shall be given in writing and shall be deemed
effectively given upon personal delivery to the party to be notified or upon
delivery by confirmed facsimile transmission, nationally recognized overnight
courier service, or upon deposit with the United States Post Office, by
registered or certified mail, postage prepaid and addressed to the party to be
notified at the address indicated for such party on the signature page hereof,
or at such other address as such party may designate by ten (10) days advance
written notice to the other parties.

            2.6 Entire Agreement; Amendments and Waivers. This Agreement
(including the Exhibits hereto, if any) constitutes the full and entire
understanding and agreement among the parties with regard to the subjects hereof
and thereof. Any term of this Agreement may be amended and the observance of any
term of this Agreement may be waived (either generally or in a particular
instance and either retroactively or prospectively), only with the written
consent of the Company and the holders of a majority of the Registrable
Securities then outstanding, which amendment shall be binding on all Holders.

            2.7 Severability. If one or more provisions of this Agreement are
held to be unenforceable under applicable law, such provision shall be excluded
from this Agreement and the balance of the Agreement shall be interpreted as if
such provision were so excluded and shall be enforceable in accordance with its
terms.

            2.8 Aggregation of Stock. All shares of Registrable Securities held
or acquired by affiliated entities or persons shall be aggregated together for
the purpose of determining the availability of any rights under this Agreement.

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      IN WITNESS WHEREOF, the parties hereto have executed this Registration
Rights Agreement on the date first above written.

AGREED TO:                            COMPANY:

LASALLE ST. SECURITIES, L.L.C.        AHPC HOLDINGS, INC.

By: __________________________        By: _____________________________________
Its: _________________________            Alan Zeffer, Chief Executive Officer

                                      INVESTORS:

                                      By: _____________________________________
                                          ALAN ZEFFER, on behalf of each
                                          Investor named on Exhibit A attached,
                                          pursuant to power of attorney
                                          contained in the Investor's
                                          Subscription Agreement

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                                   SCHEDULE A

                             SCHEDULE OF INVESTORS

Name of Investor                         Address

                                      A-1<PAGE>
                                                                  EXHIBIT 10.163

                                                THE IMMUNE RESPONSE CORPORATION

[ ]                                             NOTICE OF GRANT OF STOCK OPTIONS

[ ]                                             ID: 33-0255679

                                                AND OPTION AGREEMENT

[ ]                                             5931 Darwin Court

[ ]                                             Carlsbad, CA  92008

JOHN N. BONFIGLIO                               OPTION NUMBER:     00003389
13195 SEAGROVE STREET                           PLAN:              2003
SAN DIEGO, CA 92130                             ID:                ###-##-####

Effective 12/1/2004, you have been granted a(n) Non-Qualified Stock Option to
buy 75,000 shares of The Immune Response Corporation (the Company) stock at
$1.3400 per share.

The total option price of the shares granted is $100,500.00.

Shares in each period will become fully vested on the date shown.

               Shares         Vest Type         Full Vest         Expiration

                     75,000     On Vest Date         12/1/2004      12/1/2014

By your signature and the Company's signature below, you and the Company agree
that these options are granted under and governed by the terms and conditions of
the Company's Stock Option Plan as amended and the Option Agreement, all of
which are attached and made a part of this document.

/s/ Michael K. Green
-----------------------------------
The Immune Response Corporation                      Date      March 4, 2005
                                                               -------------

/s/ John N. Bonfiglio
-----------------------------------
John N. Bonfiglio                                    Date      March 4, 2005
                                                               -------------
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IT IS UNLAWFUL TO CONSUMMATE A SALE OR TRANSFER OF THIS SECURITY, OR ANY
INTEREST THEREIN, OR TO RECEIVE ANY CONSIDERATION THEREFOR, WITHOUT THE PRIOR
WRITTEN CONSENT OF THE CALIFORNIA CORPORATIONS COMMISSIONER OF THE STATE OF
CALIFORNIA, EXCEPT AS PERMITTED IN THE COMMISSIONER'S RULES.

                         THE IMMUNE RESPONSE CORPORATION
                                 2003 STOCK PLAN
                                OPTION AGREEMENT
                                (STANDARD GRANT)

THE IMMUNE RESPONSE CORPORATION (the "Company"), pursuant to its 2003 Stock Plan
as adopted by the Board of Directors of the Company effective February 25, 2003
(the "Plan"), grants to Optionholder the right to purchase the number of shares
of the Company's Common Stock set forth in the Notice of Grant of Stock Options
("Grant Notice") delivered with this document to Optionholder, on the terms and
conditions set forth below and in the Grant Notice and the Plan (such right is
hereinafter referred to as the "Option"). This document and the Grant Notice
together comprise the option agreement for the Option (this "Option Agreement").

                          GENERAL TERMS AND CONDITIONS

The Option is granted subject to the following terms and conditions. Defined
terms not explicitly defined in this Option Agreement but defined in the Plan
shall have the same definitions as in the Plan.

1.       NUMBER OF SHARES AND EXERCISE PRICE. The Option may only be exercised
for whole shares of Common Stock, up to the total number of shares of Common
Stock set forth in the Grant Notice. The number of shares of Common Stock
subject to the Option and Optionholder's exercise price per share referenced in
Optionholder's Grant Notice may be adjusted from time to time for capitalization
adjustments, as provided in the Plan.

2.       VESTING. Subject to the limitations contained herein and in the Plan,
the Option will vest as provided in the vesting schedule set forth in the Grant
Notice, provided that Optionholder continues his or her Service with the Company
during such vesting schedule, until fully vested or terminated under the terms
of this Option Agreement and the Plan. The vesting of the Option shall cease
upon termination of Optionholder's Service with the Company.

3.       EXERCISABILITY OF THE OPTION. Optionholder may exercise only the vested
portion of the Option during its term by delivering a Notice of Exercise (on
such terms and on such form as may be designated by the Company) together with
the consideration for the exercise of the Option to the address provided in the
form of Notice of Exercise, or to such other person as the Company may
designate, during regular business hours, together with such additional
documents as the Company may then require. The Notice of Exercise must specify
the number of shares of Common Stock to be purchased by Optionholder upon the
exercise of the Option and how such shares shall be registered. The Notice of
Exercise shall be effective upon receipt by the Company.

4.       METHOD OF PAYMENT.

         (A) Payment of the exercise price is due in full upon exercise of all
or any part of the Option. Optionholder may elect to make payment of the
exercise price:

(i)      by personal check, cashier's check or money order;

(ii)     by cashless exercise, whereby Optionholder provides irrevocable
         direction to a securities broker approved by the Company to sell Common
         Shares underlying the Option and to deliver all or part of the sales
         proceeds to the Company in payment of all or part of the Exercise
         Price and any withholding taxes;

(iii)    by delivery and surrender to the Company of already-owned shares of
         Common Stock either that Optionholder has held for the period required
         to avoid a charge to the Company's reported earnings (generally six
         months) or that Optionholder did not acquire, directly or indirectly
         from the Company, that are owned free and clear of any liens, claims,
         encumbrances or security interests, and that are valued at Fair Market
         Value on the date of exercise.
<PAGE>
"Delivery" for these purposes, in the sole discretion of the Company at the time
Optionholder exercises the Option, shall include delivery to the Company of
Optionholder's attestation of ownership of such shares of Common Stock in a form
approved by the Company.

         (B) Notwithstanding the foregoing, Optionholder may not exercise the
Option by a cashless exercise or tender to the Company of Common Stock to the
extent such cashless exercise or tender would violate the provisions of any law,
regulation or agreement restricting the redemption of the Company's stock.

5.       SECURITIES LAW COMPLIANCE. Notwithstanding anything to the contrary
contained herein, Optionholder may not exercise the Option unless the Company
determines that (i) such exercise would be in material compliance with
applicable laws and regulations, and (ii) shares of Common Stock issuable upon
such exercise are then registered under the Securities Act or such exercise and
issuance would be exempt from the registration requirements of the Securities
Act and of any applicable state securities laws.

6.       RESTRICTIONS ON RESALE. Notwithstanding anything to the contrary
contained herein, Optionholder may not sell any shares issued upon exercise of
the Option at such time that applicable law or Company policy may prohibit such
a sale. This restriction on resale shall be applicable until the termination of
the Optionholder's Service.

7.       TAX WITHHOLDING OBLIGATIONS. At the time Optionholder exercises the
Option and as a condition for the exercise of the Option, in whole or in part,
or at any time thereafter as requested by the Company, Optionholder hereby
authorizes withholding from payroll and any other amounts payable to
Optionholder, and otherwise agrees to make adequate provision for (including by
means of a "cashless exercise"), any sums required to satisfy the applicable
federal, state, local and foreign tax withholding obligations of the Company or
an Affiliate, if any, which arise in connection with the Option.

8.       TERM.  Optionholder may not exercise the Option before the commencement
of its term or after its term expires.  The term of the Option commences on the
Date of Grant and expires upon the EARLIEST of the following:

(i)      ninety (90) days after the termination of Optionholder's Service for
         any reason other than for Optionholder's disability or death, provided
         that if during any part of such ninety (90) day period the Option is
         not exercisable solely because of the condition set forth in Section 5
         relating to "Securities Law Compliance," the Option shall not expire
         until the earlier of the Expiration Date or until it shall have been
         exercisable for an aggregate period of ninety (90) days after the
         termination of Optionholder's Service;

(ii)     six (6) months after the termination of Optionholder's Service due to
         Optionholder's disability;

(iii)    six (6) months after Optionholder's death if Optionholder dies either
         during Optionholder's Service or within ninety (90) days after
         Optionholder's Service terminates;

(iv)     the Expiration Date indicated in the Grant Notice; or

(v)      the day before the tenth (10th) anniversary of the date of grant of the
         Option.

9.       NONSTATUTORY STOCK OPTION.  The Option is a nonstatutory stock option
         and not an incentive stock option within the meaning of that term in
         Section 422 of the Internal Revenue Code of 1986, as amended

10.      OPTION NOT A SERVICE CONTRACT.  Neither the Option nor this Option
         Agreement is an employment or service contract, and nothing in the
         Option Agreement or the Plan shall obligate the Company or an
         Affiliate, their respective shareholders, Boards of Directors, Officers
         or Employees to continue any relationship that Optionholder might have
         as an employee, Director or Consultant for the Company or an Affiliate.

11.      CONTROLLING DOCUMENTS. In the event of any conflict among this
document, the Grant Notice and the Plan, the provisions of the Plan shall
supersede the provisions of this document and the Grant Notice, and the
provisions of this document shall supersede the provisions of the Grant Notice.

12.      APPLICABLE LAW. This Option Agreement shall be governed by, and
construed in accordance with the laws of the State of California, as such laws
are applied to contracts entered into and performed in such state.
<PAGE>
THE IMMUNE RESPONSE CORPORATION              OPTIONHOLDER

By:  /s/ Michael K. Green                    /s/ John N. Bonfiglio
     ------------------------------------    -----------------------------------
                         Signature                            Signature

Title: Vice President, Finance and CFO       Date:  March 4, 2005
       -------------------------------              ----------------------------

Date:  March 4, 2005
       ---------------------------------

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00081-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00081-of-00352.parquet"}]]