Document:

EX-10.1

 Exhibit 10.1 

Execution Version 

AVROBIO, INC. 

EMPLOYMENT AGREEMENT 

This Employment Agreement (“Agreement”) is made as of the 17th day of December, 2018, between AVROBIO, Inc., a Delaware corporation
(the “Company”), and Erik Ostrowski (the “Executive”). 
 WHEREAS, the Company desires to employ the Executive and the
Executive desires to be employed by the Company commencing on January 2, 2019, unless another date is agreed to by the parties. The Executive’s first day of employment shall be the “Effective Date” of this Agreement. 

WHEREAS, to protect the Company’s proprietary information and goodwill, as a condition of Executive’s employment, the Executive and
the Company will become parties to Employee Confidentiality, Assignment and Noncompetition Agreement (the “Restrictive Covenants Agreement”) which is being provided to Executive along with this Agreement and at least ten (10) business
days before the Effective Date. Executive has a right to consult with counsel prior to signing the Restrictive Covenants Agreement. 
 NOW,
THEREFORE, in consideration of the mutual covenants and agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties agree as follows: 

1.    Employment. 

(a)    Term. The term of this Agreement shall commence on the Effective Date and continue until terminated in
accordance with the provisions hereof (the “Term”). The Executive’s employment with the Company will be “at will,” meaning that the Executive’s employment may be terminated by the Company or the Executive at any time
and for any reason subject to the terms of this Agreement. 
 (b)    Position and Duties. During the Term, the
Executive shall serve as the Chief Financial Officer of the Company, and shall have supervision and control over and responsibility for the day-to-day business and
affairs of the finance department of the Company and shall have such other powers and duties as may from time to time be prescribed by the Board of Directors of the Company (the “Board”), the Chief Executive Officer of the Company (the
“CEO”) or other authorized executive. The Executive shall devote his full working time and efforts to the business and affairs of the Company. Notwithstanding the foregoing, the Executive may serve on other boards of directors, with the
approval of the Board, or engage in religious, charitable or other community activities as long as such services and activities are disclosed to the Board and do not materially interfere with the Executive’s performance of his duties to the
Company as provided in this Agreement. For the avoidance of doubt, the Executive may continue to serve in the roles set forth on Schedule 1 hereto without the necessity of further approval from the Board, provided that no conflicts result in the
future from the Executive’s service in such role. 

 2.    Compensation and Related Matters. 

(a)    Base Salary. During the Term, the Executive’s annual base salary shall be $412,000. The Executive’s
base salary shall be reviewed annually by the Board or the Compensation Committee of the Board (the “Compensation Committee”). The base salary in effect at any given time is referred to herein as “Base Salary.” The Base Salary
shall be payable in a manner that is consistent with the Company’s usual payroll practices for executive officers. 

(b)    Incentive Compensation. During the Term, the Executive shall be eligible to receive cash incentive
compensation as determined by the Board or the Compensation Committee from time to time. The Executive’s initial target annual incentive compensation shall be forty percent (40%) of his Base Salary (as in effect at any time, the
“Target Annual Incentive Compensation”). To earn incentive compensation, the Executive must be employed by the Company on the day such incentive compensation is paid. 

(c)    Expenses. The Executive shall be entitled to receive prompt reimbursement for all reasonable expenses
incurred by the Executive during the Term in performing services hereunder, in accordance with the policies and procedures then in effect and established by the Company for its senior officers. 

(d)    Other Benefits. During the Term, the Executive shall be eligible to participate in or receive benefits under
the Company’s employee benefit plans in effect from time to time, subject to the terms of such plans. Additionally, during the Term, the Executive shall be eligible to receive such benefits and perquisites as those made available to the other
employees of the Company generally. 
 (e)    Vacations. During the Term, the Executive shall be entitled to paid
vacation in accordance with the Company’s policies and procedures, which shall be a minimum of 20 days in addition to the Company’s paid holidays. The Executive shall also be entitled to all paid holidays given by the Company to its
executive officers. 
 (f)    Signing Bonus. The Company shall pay the Executive a signing bonus in the form of a
cash bonus and an award of restricted stock units. With respect to the cash bonus component, the Company shall pay the Executive a lump sum of $170,000 (the “Cash Signing Bonus”) within 30 days after the Effective
Date, provided that, if within the one year period immediately following the Effective Date, (i) the Executive terminates his employment other than for Good Reason (as defined below) or (ii) the Company terminates the
Executive’s employment for Cause (as defined below), then the Executive shall repay the entire Cash Signing Bonus to the Company within 30 days after the Date of Termination (as defined below). The Cash Signing Bonus shall be subject to
applicable deductions and tax withholdings. With respect to the equity component, the Company will grant the Executive an award of a number of restricted stock units, with such number to equal $36,000 divided by the closing price of the
Company’s stock on the Effective Date (the “Signing Bonus Award”). The Signing Bonus Award shall vest on the same schedule as the New Hire Award (as defined below), subject to the Executive’s continued service relationship with
the Company, and shall be governed by the terms and conditions set forth in the Equity Documents (as defined below), including without limitation the applicable award agreement. 

  
 2 

 (g)    Equity. The Executive shall also be eligible to
participate in the Company’s equity incentive plan, subject to approval by the Board or Compensation Committee. The Company will grant the Executive an option to purchase 186,000 shares of the Company’s common stock (“New Hire
Award”). The New Hire Award shall vest over four years, with twenty-five percent of the New Hire Award vesting on the one-year anniversary of the Effective Date and the remaining shares vesting in thirty-six equal monthly installments following the one-year anniversary of the Effective Date, subject to the Executive’s continued service relationship with the
Company. The New Hire Award, together with any other equity awards held by the Executive (including without limitation the Signing Bonus Award), shall be governed by the terms and conditions of the Company’s applicable equity incentive plan(s)
and the applicable award agreement(s) governing the terms of such equity awards held by the Executive (collectively, the “Equity Documents”); provided, however, and notwithstanding anything to the contrary in the Equity Documents,
Section 4(b)(ii) or Section 5(a)(ii) of this Agreement (as applicable) shall apply in the event of a termination by the Company without Cause or by the Executive for Good Reason (as such terms are defined below). 

3.    Termination. During the Term, the Executive’s employment hereunder may be terminated without any breach
of this Agreement under the following circumstances: 
 (a)    Death. The Executive’s employment hereunder
shall terminate upon his death. 
 (b)    Disability. The Company may terminate the Executive’s employment
if he is disabled and unable to perform the essential functions of the Executive’s then existing position or positions under this Agreement with or without reasonable accommodation for a period of 180 days (which need not be consecutive) in any
12-month period. If any question shall arise as to whether during any period the Executive is disabled so as to be unable to perform the essential functions of the Executive’s then existing position or
positions with or without reasonable accommodation, the Executive may, and at the request of the Company shall, submit to the Company a certification in reasonable detail by a physician selected by the Company to whom the Executive or the
Executive’s guardian has no reasonable objection as to whether the Executive is so disabled or how long such disability is expected to continue, and such certification shall for the purposes of this Agreement be conclusive of the issue. The
Executive shall cooperate with any reasonable request of the physician in connection with such certification. If such question shall arise and the Executive shall fail to submit such certification, the Company’s determination of such issue
shall be binding on the Executive. Nothing in this Section 3(b) shall be construed to waive the Executive’s rights, if any, under existing law including, without limitation, the Family and Medical Leave Act of 1993, 29 U.S.C. §2601
et seq. and the Americans with Disabilities Act, 42 U.S.C. §12101 et seq. 
 (c)    Termination by
Company for Cause. The Company may terminate the Executive’s employment hereunder for Cause. For purposes of this Agreement, “Cause” shall mean: (i) conduct by the Executive constituting a material act of misconduct in
connection with the performance of his duties, including, without limitation, misappropriation of funds or 

  
 3 

 
property of the Company or any of its subsidiaries or affiliates other than the occasional, customary and de minimis use of Company property for personal purposes; (ii) the commission by the
Executive of any felony or a misdemeanor involving moral turpitude, material deceit or dishonesty, or fraud, or any conduct by the Executive that would reasonably be expected to result in material injury or reputational harm to the Company or any of
its subsidiaries or affiliates if he were retained in his position; (iii) continued non-performance by the Executive of his duties hereunder (other than by reason of the Executive’s physical or
mental illness, incapacity or disability) which has continued for more than 30 days following written notice (with a reasonably detailed summary of such alleged non-performance specified) of such non-performance from the Company’s CEO; (iv) a breach by the Executive of any of the provisions incorporated into or contained in Section 7 of this Agreement; (v) a material violation by the
Executive of the Company’s written employment policies; or (vi) failure to cooperate with a bona fide internal investigation or an investigation by regulatory or law enforcement authorities, after being instructed by the Company to
cooperate, or the willful destruction or failure to preserve documents or other materials known to be relevant to such investigation or the inducement of others to fail to cooperate or to produce documents or other materials in connection with such
investigation. 
 (d)    Termination Without Cause. The Company may terminate the Executive’s employment
hereunder at any time without Cause. Any termination by the Company of the Executive’s employment under this Agreement which does not constitute a termination for Cause under Section 3(c) and does not result from the death or disability of
the Executive under Section 3(a) or (b) shall be deemed a termination without Cause. 
 (e)    Termination
by the Executive. The Executive may terminate his employment hereunder at any time for any reason, including but not limited to Good Reason. For purposes of this Agreement, “Good Reason” shall mean that the Executive has complied with
the “Good Reason Process” (hereinafter defined) following the occurrence of any of the following events: (i) a material diminution in the Executive’s responsibilities, authority or duties or reporting relationship, which in the
case of a Change in Control (as defined in Section 5) shall include the failure of the acquiring company to appoint Executive as the CFO of the senior most entity in the affiliated group in which the acquiring company is then a member;
(ii) a material diminution in the Executive’s Base Salary except for across-the-board salary reductions based on the Company’s financial performance
similarly affecting all or substantially all senior management employees of the Company; (iii) a material change in the geographic location at which the Executive provides services to the Company; or (iv) a material breach of this
Agreement by the Company. “Good Reason Process” shall mean that (i) the Executive reasonably determines in good faith that a “Good Reason” condition has occurred; (ii) the Executive notifies the Company in writing of
the first occurrence of the Good Reason condition within 60 days of the first occurrence of such condition; (iii) the Executive cooperates in good faith with the Company’s efforts, for a period not less than 30 days following such notice
(the “Cure Period”), to remedy the condition; (iv) notwithstanding such efforts, the Good Reason condition continues to exist; and (v) the Executive terminates his employment within 60 days after the end of the Cure Period. If
the Company cures the Good Reason condition during the Cure Period, Good Reason shall be deemed not to have occurred. 

  
 4 

 (f)    Notice of Termination. Except for termination as specified
in Section 3(a), any termination of the Executive’s employment by the Company or any such termination by the Executive shall be communicated by written Notice of Termination to the other party hereto. For purposes of this Agreement, a
“Notice of Termination” shall mean a notice which shall indicate the specific termination provision in this Agreement relied upon. 

(g)    Date of Termination. “Date of Termination” shall mean: (i) if the Executive’s employment
is terminated by his death, the date of his death; (ii) if the Executive’s employment is terminated on account of disability under Section 3(b) or by the Company for Cause under Section 3(c), the date on which Notice of
Termination is given; (iii) if the Executive’s employment is terminated by the Company under Section 3(d), the date on which a Notice of Termination is given; (iv) if the Executive’s employment is terminated by the Executive
under Section 3(e) without Good Reason, 30 days after the date on which a Notice of Termination is given, and (v) if the Executive’s employment is terminated by the Executive under Section 3(e) with Good Reason, the date on which
a Notice of Termination is given after the end of the Cure Period. Notwithstanding the foregoing, in the event that the Executive gives a Notice of Termination to the Company, the Company may unilaterally accelerate the Date of Termination and such
acceleration shall not result in a termination by the Company for purposes of this Agreement. 
 4.    Compensation
Upon Termination. 
 (a)    Termination Generally. If the Executive’s employment with the Company is
terminated for any reason, the Company shall pay or provide to the Executive (or to his authorized representative or estate) (i) any Base Salary earned through the Date of Termination, unpaid expense reimbursements (subject to, and in
accordance with, Section 2(c) of this Agreement) and unused vacation that accrued through the Date of Termination on or before the time required by law but in no event more than 30 days after the Executive’s Date of Termination; and
(ii) any vested benefits the Executive may have under any employee benefit plan of the Company through the Date of Termination, which vested benefits shall be paid and/or provided in accordance with the terms of such employee benefit plans
(collectively, the “Accrued Benefit”). 
 (b)    Termination by the Company Without Cause or by the
Executive with Good Reason. During the Term, if the Executive’s employment is terminated by the Company without Cause as provided in Section 3(d), or the Executive terminates his employment for Good Reason as provided in
Section 3(e), then the Company shall pay the Executive his Accrued Benefit. In addition, subject to the Executive signing a separation agreement containing, among other provisions, a general release of claims in favor of the Company and related
persons and entities, confidentiality, return of property and non-disparagement, a reaffirmation of all of the Executive’s Continuing Obligations and, in the Company’s sole discretion, a one-year post-employment noncompetition agreement, and that shall provide that if the Executive breaches any of the Executive’s Continuing Obligations, all payments of the Severance Amount shall immediately
cease, in a form and manner satisfactory to the Company (the “Separation Agreement and Release”) and the Separation Agreement and Release becoming irrevocable (after a seven (7) business day revocation period) and fully effective and,
if applicable, the 

  
 5 

 
Executive resigning as a member of the Board of Directors, all within 60 days after the Date of Termination (or such shorter time period provided in the Separation Agreement and Release): 

(i)    the Company shall pay the Executive an amount equal to 0.75 times the sum of the Executive’s
Base Salary (the “Severance Amount”) provided in the event the Executive is entitled to any payments pursuant to the Restrictive Covenants Agreement, the Severance Amount received in any calendar year will be reduced by the amount the
Executive is paid in the same such calendar year pursuant to the Restrictive Covenants Agreement (the “Restrictive Covenants Agreement Setoff”); 

(ii)    notwithstanding anything to the contrary in any applicable option agreement or stock-based award
agreement, all time-based stock options and other time-based stock-based awards held by the Executive in which such stock option or other stock-based award would have vested if the Executive had remained employed for an additional nine months
following the Date of Termination shall vest and become exercisable or nonforfeitable as of the Date of Termination; 

(iii)    if the Executive was participating in the Company’s group health plan immediately prior to
the Date of Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for nine months or the Executive’s COBRA health continuation period, whichever ends earlier, in an amount equal to
the monthly employer contribution that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by the Company; and 

(iv)    the amounts payable under Section 4(b)(i) and (iii) shall be paid out in substantially
equal installments in accordance with the Company’s payroll practice over nine months commencing within 60 days after the Date of Termination; provided, however, that if the 60-day period
begins in one calendar year and ends in a second calendar year, the Severance Amount shall begin to be paid in the second calendar year by the last day of such 60-day period; provided, further, that the
initial payment shall include a catch-up payment to cover amounts retroactive to the day immediately following the Date of Termination. Each payment pursuant to this Agreement is intended to constitute a
separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2). 

5.    Change in Control Payment. The provisions of this Section 5 set forth certain terms of an agreement
reached between the Executive and the Company regarding the Executive’s rights and obligations upon the occurrence of a Change in Control of the Company. In the event of a Change in Control during the Term, all time-based stock options and
other time-based stock-based awards held by the Executive as of the Effective Date that were granted to the Executive at least 12 months prior to the Effective Date shall immediately accelerate and become fully exercisable or nonforfeitable as of
immediately prior to such Change in Control. These provisions are intended to assure and encourage in advance the Executive’s continued attention and dedication to his assigned duties and his objectivity during the pendency and after the
occurrence of any such event. These provisions shall apply in lieu of, and expressly supersede, the provisions of Section 4(b) regarding severance pay and benefits upon a termination of 

  
 6 

 
employment, if such termination of employment occurs within three months prior to or 18 months after the occurrence of the first event constituting a Change in Control. These provisions shall
terminate and be of no further force or effect beginning 18 months after the occurrence of a Change in Control. 

(a)    Change in Control. During the Term, if within three months prior to or 18 months after a Change in Control,
the Executive’s employment is terminated by the Company without Cause as provided in Section 3(d) or the Executive terminates his employment for Good Reason as provided in Section 3(e), then, subject to the signing of the Separation
Agreement and Release by the Executive and the Separation Agreement and Release becoming irrevocable and fully effective and, if applicable, the Executive resigning as a member of the Board of Directors, all within 60 days after the Date of
Termination (or such shorter time period provided in the Separation Agreement and Release): 
 (i)    the
Company shall pay the Executive a lump sum in cash in an amount equal to one times the sum of (A) the Executive’s current Base Salary (or the Executive’s Base Salary in effect immediately prior to the Change in Control, if higher) and
(B) the Executive’s Target Annual Incentive Compensation then in effect (together the “Change in Control Payment”), provided the Change in Control Payment shall be reduced by the amount of the Restrictive Covenants Agreement
Setoff, if applicable, paid or to be paid in the same calendar year; 
 (ii)    notwithstanding anything
to the contrary in any applicable option agreement or stock-based award agreement, all time-based stock options and other time-based stock-based awards held by the Executive shall immediately accelerate and become fully exercisable or nonforfeitable
as of the Date of Termination; 
 (iii)    if the Executive was participating in the Company’s group
health plan immediately prior to the Date of Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for twelve months or the Executive’s COBRA health continuation period,
whichever ends earlier, in an amount equal to the monthly employer contribution that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by the Company; and 

(iv)    The amounts payable under Section 5(a)(i) and (iii) shall be paid or commence to be paid
within 60 days after the Date of Termination; provided, however, that if the 60-day period begins in one calendar year and ends in a second calendar year, such payment shall be paid or commence to be paid in
the second calendar year by the last day of such 60-day period. 

(b)    Additional Limitation. 

(i)    Anything in this Agreement to the contrary notwithstanding, in the event that the amount of any
compensation, payment or distribution by the Company to or for the benefit of the Executive, whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise, calculated in a manner consistent

  
 7 

 
with Section 280G of the Internal Revenue Code of 1986, as amended (the “Code”) and the applicable regulations thereunder (the “Aggregate Payments”), would be subject to
the excise tax imposed by Section 4999 of the Code, then the Aggregate Payments shall be reduced (but not below zero) so that the sum of all of the Aggregate Payments shall be $1.00 less than the amount at which the Executive becomes subject to
the excise tax imposed by Section 4999 of the Code; provided that such reduction shall only occur if it would result in the Executive receiving a higher After Tax Amount (as defined below) than the Executive would receive if the Aggregate
Payments were not subject to such reduction. In such event, the Aggregate Payments shall be reduced in the following order, in each case, in reverse chronological order beginning with the Aggregate Payments that are to be paid the furthest in time
from consummation of the transaction that is subject to Section 280G of the Code: (1) cash payments not subject to Section 409A of the Code; (2) cash payments subject to Section 409A of the Code; (3) equity-based
payments and acceleration; and (4) non-cash forms of benefits; provided that in the case of all the foregoing Aggregate Payments all amounts or payments that are not subject to calculation under Treas.
Reg. §1.280G-1, Q&A-24(b) or (c) shall be reduced before any amounts that are subject to calculation under Treas. Reg.
§1.280G-1, Q&A-24(b) or (c). 

(ii)    For purposes of this Section 5(b), the “After Tax Amount” means the amount of the
Aggregate Payments less all federal, state, and local income, excise and employment taxes imposed on the Executive as a result of the Executive’s receipt of the Aggregate Payments. For purposes of determining the After Tax Amount, the Executive
shall be deemed to pay federal income taxes at the highest marginal rate of federal income taxation applicable to individuals for the calendar year in which the determination is to be made, and state and local income taxes at the highest marginal
rates of individual taxation in each applicable state and locality, net of the maximum reduction in federal income taxes which could be obtained from deduction of such state and local taxes. 

(iii)    The determination as to whether a reduction in the Aggregate Payments shall be made pursuant to
Section 5(b)(i) shall be made by a nationally recognized accounting firm selected by the Company (the “Accounting Firm”), which shall provide detailed supporting calculations both to the Company and the Executive within 15 business
days of the Date of Termination, if applicable, or at such earlier time as is reasonably requested by the Company or the Executive. Any determination by the Accounting Firm shall be binding upon the Company and the Executive. 

(c)    Definitions. For purposes of this Section 5, the following terms shall have the following meanings:

 “Change in Control” shall mean any of the following: 

(i)    any “person,” as such term is used in Sections 13(d) and 14(d) of the Securities Exchange
Act of 1934, as amended (the “Act”) (other than the Company, any of its subsidiaries, or any trustee, fiduciary or other person or entity holding securities under any employee benefit plan or trust of the Company or any of its
subsidiaries), together with all “affiliates” and “associates” (as such terms are defined in Rule 12b-2 

  
 8 

 
under the Act) of such person, shall become the “beneficial owner” (as such term is defined in Rule 13d-3 under the Act), directly or indirectly,
of securities of the Company representing 50 percent or more of the combined voting power of the Company’s then outstanding securities having the right to vote in an election of the Board (“Voting Securities”) (in such case other
than as a result of an acquisition of securities directly from the Company); or 
 (ii)    the date a
majority of the members of the Board is replaced during any 12-month period by directors whose appointment or election is not endorsed by a majority of the members of the Board before the date of the
appointment or election; or 
 (iii)    the consummation of (A) any consolidation or merger of the
Company where the stockholders of the Company, immediately prior to the consolidation or merger, would not, immediately after the consolidation or merger, beneficially own (as such term is defined in Rule
13d-3 under the Act), directly or indirectly, shares representing in the aggregate more than 50 percent of the voting shares of the Company issuing cash or securities in the consolidation or merger (or of
its ultimate parent corporation, if any), or (B) any sale or other transfer (in one transaction or a series of transactions contemplated or arranged by any party as a single plan) of all or substantially all of the assets of the Company. 

Notwithstanding the foregoing, a “Change in Control” shall not be deemed to have occurred for purposes of the foregoing clause
(i) solely as the result of an acquisition of securities by the Company which, by reducing the number of shares of Voting Securities outstanding, increases the proportionate number of Voting Securities beneficially owned by any person to
50 percent or more of the combined voting power of all of the then outstanding Voting Securities; provided, however, that if any person referred to in this sentence shall thereafter become the beneficial owner of any additional shares of Voting
Securities (other than pursuant to a stock split, stock dividend, or similar transaction or as a result of an acquisition of securities directly from the Company) and immediately thereafter beneficially owns 50 percent or more of the combined
voting power of all of the then outstanding Voting Securities, then a “Change in Control” shall be deemed to have occurred for purposes of the foregoing clause (i). 

6.    Section 409A. 

(a)    Anything in this Agreement to the contrary notwithstanding, if at the time of the Executive’s separation from
service within the meaning of Section 409A of the Code, the Company determines that the Executive is a “specified employee” within the meaning of Section 409A(a)(2)(B)(i) of the Code, then to the extent any payment or benefit
that the Executive becomes entitled to under this Agreement on account of the Executive’s separation from service would be considered deferred compensation otherwise subject to the 20 percent additional tax imposed pursuant to
Section 409A(a) of the Code as a result of the application of Section 409A(a)(2)(B)(i) of the Code, such payment shall not be payable and such benefit shall not be provided until the date that is the earlier of (A) six months and one
day after the Executive’s separation from service, or (B) the Executive’s death. If any such delayed cash payment is otherwise payable on an installment basis, the first payment shall include a
catch-up payment covering amounts that would otherwise have been paid during the six-month period but for the application of this provision, and the balance of the
installments shall be payable in accordance with their original schedule. 

  
 9 

 (b)    All in-kind benefits
provided and expenses eligible for reimbursement under this Agreement shall be provided by the Company or incurred by the Executive during the time periods set forth in this Agreement. All reimbursements shall be paid as soon as administratively
practicable, but in no event shall any reimbursement be paid after the last day of the taxable year following the taxable year in which the expense was incurred. The amount of in-kind benefits provided or
reimbursable expenses incurred in one taxable year shall not affect the in-kind benefits to be provided or the expenses eligible for reimbursement in any other taxable year (except for any lifetime or other
aggregate limitation applicable to medical expenses). Such right to reimbursement or in-kind benefits is not subject to liquidation or exchange for another benefit. 

(c)    To the extent that any payment or benefit described in this Agreement constitutes
“non-qualified deferred compensation” under Section 409A of the Code, and to the extent that such payment or benefit is payable upon the Executive’s termination of employment, then such
payments or benefits shall be payable only upon the Executive’s “separation from service.” The determination of whether and when a separation from service has occurred shall be made in accordance with the presumptions set forth in
Treasury Regulation Section 1.409A-1(h). 
 (d)    The parties intend that
this Agreement will be administered in accordance with Section 409A of the Code. To the extent that any provision of this Agreement is ambiguous as to its compliance with Section 409A of the Code, the provision shall be read in such a
manner so that all payments hereunder comply with Section 409A of the Code. Each payment pursuant to this Agreement is intended to constitute a separate payment for purposes of Treasury Regulation
Section 1.409A-2(b)(2). The parties agree that this Agreement may be amended, as reasonably requested by either party, and as may be necessary to fully comply with Section 409A of the Code and all
related rules and regulations in order to preserve the payments and benefits provided hereunder without additional cost to either party. 

(e)    The Company makes no representation or warranty and shall have no liability to the Executive or any other person if
any provisions of this Agreement are determined to constitute deferred compensation subject to Section 409A of the Code but do not satisfy an exemption from, or the conditions of, such Section. 

7.    Confidential Information, Noncompetition and Cooperation. 

(a)    Restrictive Covenants Agreement. The Executive acknowledges and agrees that in consideration and as a
condition of the Executive’s employment by the Company and in exchange for, among other things, the benefits contained in this Agreement, the Executive will enter into the Restrictive Covenants Agreement, the terms of which are incorporated by
reference as material terms of this Agreement. For purposes of this Agreement, the obligations in this Section 7 and those that arise in the Restrictive Covenants Agreement and any other agreement relating to confidentiality, assignment of
inventions, or other restrictive covenants shall collectively be referred to as the “Continuing Obligations.” 

  
 10 

 (b)    Third-Party Agreements and Rights. The Executive hereby
confirms that the Executive is not bound by the terms of any agreement with any previous employer or other party which restricts in any way the Executive’s use or disclosure of information or the Executive’s engagement in any business. The
Executive represents to the Company that the Executive’s execution of this Agreement, the Executive’s employment with the Company and the performance of the Executive’s proposed duties for the Company will not violate any obligations
the Executive may have to any such previous employer or other party. In the Executive’s work for the Company, the Executive will not disclose or make use of any information in violation of any agreements with or rights of any such previous
employer or other party, and the Executive will not bring to the premises of the Company any copies or other tangible embodiments of non-public information belonging to or obtained from any such previous
employment or other party. 
 (c)    Litigation and Regulatory Cooperation. During and after the Executive’s
employment, the Executive shall reasonably cooperate with the Company in the defense or prosecution of any claims or actions now in existence or which may be brought in the future against or on behalf of the Company which relate to events or
occurrences that transpired while the Executive was employed by the Company. The Executive’s full cooperation in connection with such claims or actions shall include, but not be limited to, being available to meet with counsel to prepare for
discovery or trial and to act as a witness on behalf of the Company at mutually convenient times, taking into consideration Executive’s then current business and personal commitments. During and after the Executive’s employment, the
Executive also shall cooperate fully with the Company in connection with any investigation or review of any federal, state or local regulatory authority as any such investigation or review relates to events or occurrences that transpired while the
Executive was employed by the Company. The Company shall reimburse the Executive for any reasonable out-of-pocket expenses incurred in connection with the
Executive’s performance of obligations pursuant to this Section 7(c). 
 (d)    Relief. The Executive
agrees that it would be difficult to measure any damages caused to the Company which might result from any breach by the Executive of the promises incorporated into or set forth in this Section 7, and that in any event money damages would be an
inadequate remedy for any such breach. Accordingly, subject to Section 8 of this Agreement, the Executive agrees that if the Executive breaches, or proposes to breach, any portion of this Agreement, the Company shall be entitled, in addition to
all other remedies that it may have, to seek an injunction or other appropriate equitable relief to restrain any such breach without showing or proving any actual damage to the Company. In addition, in the event the Executive breaches this
Section 7 or the provisions incorporated herein during a period when he is receiving severance payments pursuant to Section 4 or Section 5 hereof, the Company shall have the right to suspend or terminate such severance payments. Such
suspension or termination shall not limit the Company’s other options with respect to relief for such breach and shall not relieve the Executive of his duties under this Agreement. 

(e)    Protected Disclosures and Other Protected Action. Nothing contained in this Agreement limits the
Executive’s ability to communicate with any federal, state or local governmental agency or commission, including to provide documents or other information, without notice to the Company. 

  
 11 

 8.    Consent to Jurisdiction. The parties hereby consent to the
jurisdiction of the Superior Court of the Commonwealth of Massachusetts and the United States District Court for the District of Massachusetts. Accordingly, with respect to any such court action, the Executive (a) submits to the personal
jurisdiction of such courts; (b) consents to service of process; and (c) waives any other requirement (whether imposed by statute, rule of court, or otherwise) with respect to personal jurisdiction or service of process. 

9.    Integration. This Agreement and the Restrictive Covenants Agreement constitute the entire agreement between
the parties with respect to the subject matter hereof and supersede all prior agreements between the parties concerning such subject matter. 

10.    Withholding. All payments made by the Company to the Executive under this Agreement shall be net of any tax
or other amounts required to be withheld by the Company under applicable law. 
 11.    Successor to the
Executive. This Agreement shall inure to the benefit of and be enforceable by the Executive’s personal representatives, executors, administrators, heirs, distributees, devisees and legatees. In the event of the Executive’s death after
his termination of employment but prior to the completion by the Company of all payments due to him under this Agreement, the Company shall continue such payments to the Executive’s beneficiary designated in writing to the Company prior to his
death (or to his estate, if the Executive fails to make such designation). 
 12.    Enforceability. If any
portion or provision of this Agreement (including, without limitation, any portion or provision of any section of this Agreement) shall to any extent be declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of
this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid
and enforceable to the fullest extent permitted by law. 
 13.    Survival. The provisions of this Agreement
shall survive the termination of this Agreement and/or the termination of the Executive’s employment to the extent necessary to effectuate the terms contained herein. 

14.    Waiver. No waiver of any provision hereof shall be effective unless made in writing and signed by the
waiving party. The failure of any party to require the performance of any term or obligation of this Agreement, or the waiver by any party of any breach of this Agreement, shall not prevent any subsequent enforcement of such term or obligation or be
deemed a waiver of any subsequent breach. 
 15.    Notices. Any notices, requests, demands and other
communications provided for by this Agreement shall be sufficient if in writing and delivered in person or sent by a nationally recognized overnight courier service or by registered or certified mail, postage prepaid, return receipt requested, to
the Executive at the last address the Executive has filed in writing with the Company or, in the case of the Company, at its main offices, attention of the Board. 

  
 12 

 16.    Amendment. This Agreement may be amended or modified only
by a written instrument signed by the Executive and by a duly authorized representative of the Company. 

17.    Governing Law. This is a Massachusetts contract and shall be construed under and be governed in all respects
by the laws of the Commonwealth of Massachusetts, without giving effect to the conflict of laws principles thereof. 

18.    Counterparts. This Agreement may be executed in any number of counterparts, each of which when so executed
and delivered shall be taken to be an original; but such counterparts shall together constitute one and the same document. 

19.    Successor to Company. The Company shall require any successor (whether direct or indirect, by purchase,
merger, consolidation or otherwise) to all or substantially all of the business or assets of the Company expressly to assume and agree to perform this Agreement to the same extent that the Company would be required to perform it if no succession had
taken place. Failure of the Company to obtain an assumption of this Agreement at or prior to the effectiveness of any succession shall be a material breach of this Agreement. 

20.    Gender Neutral. Wherever used herein, a pronoun in the masculine or feminine gender shall be considered as
including the opposite gender as well unless the context clearly indicates otherwise. 
 IN WITNESS WHEREOF, the parties have executed this
Agreement effective on the date and year first above written. 
  

			
	AVROBIO, INC.
		
	By:	 	 /s/ Geoff MacKay

	Name:	 	Geoff MacKay
	Title:	 	Chief Executive Officer
	
	EXECUTIVE
	
	 /s/ Erik Ostrowski

	Erik Ostrowski

  
 13 

 Schedule 1 

Approved Activities 
 None. 

 Exhibit A 

Restrictive Covenants Agreement 

  
 15EX-10.1

 Exhibit 10.1 

EXECUTION VERSION 

FIRST AMENDMENT TO RESTRUCTURING SUPPORT AGREEMENT 

This FIRST AMENDMENT TO RESTRUCTURING SUPPORT AGREEMENT (the “Amendment”), dated as of December 18, 2018, is
entered into by and among: 
 (i) PetroQuest Energy, Inc., PetroQuest Energy, L.L.C., TDC Energy, LLC, PetroQuest
Oil & Gas, L.L.C., PQ Holdings LLC, Pittrans Inc. and Sea Harvester Energy Development, L.L.C. (collectively, the “Company”); and 

(ii) the undersigned Consenting Creditors; 

The Company and each of the undersigned Consenting Creditor are referred herein as the “Parties” and individually as a
“Party.” Capitalized terms used but not defined herein shall have the meanings ascribed to them in the RSA (as defined below). 

RECITALS 

WHEREAS, the Parties are party to that certain Restructuring Support Agreement, dated as of November 6, 2018 (the
“RSA”); 
 WHEREAS, in accordance with the terms of the RSA, on November 19, 2018, the Company commenced
solicitation of the Debtors’ Chapter 11 Plan of Reorganization, reflecting the terms of the RSA; 
 WHEREAS, pursuant to
Section 9(a) of the RSA, the RSA may be modified, amended or supplemented with the written consent of the Company and the Requisite Creditors; and 

WHEREAS, the Parties desire to amend the RSA as set forth in this Amendment and the undersigned Consenting Creditors constitute the
Requisite Creditors under the RSA. 
 NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements set
forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, agree as follows: 

 

	 	1.	 Amendments. 

 

	 	(a)	 Section 5(b)(iii) of the RSA shall be amended and restated in its entirety as follows:

 “(iii) if the Company shall not have complied with each of the following milestones, which may be
extended with the consent of the Requisite Creditors (the “Milestones”): 
 (1) if, as of 11:59 p.m.
prevailing Central Time on December 31, 2018, an amended Final Cash Collateral Order, which shall be in all respects acceptable to the Requisite Creditors, has not been entered by the Court; 

 (2) if, as of 11:59 p.m. prevailing Central Time on January 3, 2019,
the Company shall not have filed amended versions of the Plan and Disclosure Statement with the Court; 
 (3) if, as of
11:59 p.m. prevailing Central Time on January 7, 2019, the Court shall not have entered an order finally approving the Disclosure Statement; 

(4) if, as of 11:59 p.m. prevailing Central Time on January 31, 2019, the Confirmation Order has not been entered by the
Court; and 
 (5) if, as of 11:59 p.m. prevailing Central Time on February 8, 2019, the Effective Date shall not have
occurred;”; and 
  

	 	(b)	 Section 5(c)(v) of the RSA is amended and restated in its entirety as follows: 

“(v) as of 11:59 p.m. prevailing Central Time on February 8, 2019, the Effective Date shall not have occurred;
or”. 
  

	 	2.	 Representations and Warranties. 

Each Party, severally and not jointly, represents and warrants to the other Parties that the following statements are true, correct and
complete as of the date hereof: 
 (a) This Amendment has been duly executed and delivered by it, and, assuming the due authorization,
execution and delivery by each of the other Parties, this Amendment constitutes the legal, valid and binding obligation of it, enforceable against it in accordance with its terms, subject to laws of general application and bankruptcy, insolvency and
other similar laws affecting creditors’ rights generally and general principles of equity. 
 (b) Such Party is validly existing and in
good standing under the laws of its jurisdiction of incorporation or organization, and has all requisite corporate, partnership, limited liability company or similar authority to enter into this Amendment and carry out the transactions contemplated
hereby and perform its obligations contemplated hereunder; and the execution and delivery of this Amendment and the performance of such Party’s obligations hereunder have been duly authorized by all necessary corporate, limited liability
company, partnership or other similar action on its part. 
  

	 	3.	 Full Force and Effect. 

The RSA shall not be amended or otherwise modified by this Amendment except as set forth in Section 1 of this Amendment. Except as amended
by this Amendment, the RSA shall continue to be and shall remain in full force and effect in accordance with its terms, and the Parties hereby ratify and confirm the RSA in all respects, as amended hereby. All references to the
“Agreement”, “herein”, “hereof”, “hereunder” or words of similar import in the RSA shall be deemed to include the RSA as amended by this Amendment. 

  
 2 

	 	4.	 Reservation of Rights. 

Nothing contained in this Amendment constitutes a waiver of any default that may heretofore or hereafter occur or have occurred and be
continuing under the RSA. Except as expressly provided herein, the execution and delivery of this Amendment does not: (i) extend the term of the RSA; (ii) give rise to any obligation on the part of any Party to extend, modify, alter, amend
or waive any term or condition of the RSA or otherwise prejudice any rights or remedies which any Party now has or may have in the future; or (iii) give rise to any defenses, setoffs, reductions or counterclaims to any Party’s right to
enforce, exercise and enjoy the benefits of their respective rights and remedies under the RSA. 
  

	 	5.	 Effect of Amendment. 

This Amendment shall be effective on the date on which the Company has received all signature pages of the Parties. 

 

	 	6.	 Miscellaneous. 

(a) The headings of the Sections of this Amendment have been inserted for convenience of reference only, are not to be considered a part
hereof, and shall in no way modify or restrict any of the terms or provisions hereof. 
 (b) This Amendment shall be construed and enforced
in accordance with, and the rights of the Parties shall be governed by, the law of the State of Texas, without giving effect to the conflict of laws principles thereof. 

(c) This Amendment may be executed in several counterparts, each of which shall be deemed to be an original, and all of which together shall be
deemed to be one and the same agreement. Execution copies of this Amendment may be delivered by electronic mail, or otherwise, which shall be deemed to be an original for the purposes of this paragraph. 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
 3 

 IN WITNESS WHEREOF, the Parties have caused this Amendment to be executed and delivered by
their respective duly authorized officers, solely in their respective capacity as officers of the undersigned and not in any other capacity, as of the date set forth above. 

 

			
	PETROQUEST ENERGY, INC.
	PETROQUEST ENERGY, L.L.C.
	TDC ENERGY, LLC
	
	On behalf of itself and each of its wholly-owned direct and indirect subsidiaries
		
	By:	 	 /s/ Charles T. Goodson

	Name:	 	Charles T. Goodson
	Title:	 	President, CEO & Chairman

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

  

 CONSENTING TERM LOAN LENDERS: 

 

			
	MainStay MacKay High Yield Corporate Bond Fund
	By: MacKay Shields LLC, as investment subadvisor
		
	By:	 	 /s/ Andrew Susser

	Name:	 	Andrew Susser
	Title:	 	Executive Managing Director
	
	 MainStay VP MacKay High Yield Corporate Bond Portfolio

	By: MacKay Shields LLC, as investment subadvisor
		
	By:	 	 /s/ Andrew Susser

	Name:	 	Andrew Susser
	Title:	 	Executive Managing Director
	
	 MainStay MacKay Short Duration High Yield Fund

	By: MacKay Shields LLC, as investment subadvisor
		
	By:	 	 /s/ Andrew Susser

	Name:	 	Andrew Susser
	Title:	 	Executive Managing Director

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

 
			
	 Corre Opportunities Qualified Master Fund, LP

		
	By:	 	 /s/ Eric Soderland

	Name: Eric Soderland
	Title: Authorized Signatory
	
	Corre Opportunities II Master Fund, LP
		
	By:	 	 /s/ Eric Soderland

	Name: Eric Soderland
	Title: Authorized Signatory
	
	Corre Horizon Interim Fund LLC
		
	By:	 	 /s/ Eric Soderland

	Name: Eric Soderland
	Title: Authorized Signatory

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

 CONSENTING SECOND LIEN NOTEHOLDERS: 

 

					
	CORRE OPPORTUNITIES QUALIFIED MASTER FUND, LP
		
	By:	 	 /s/ Eric Soderland

	Name: Eric Soderland
	Title: Authorized Signatory
	
	CORRE OPPORTUNITIES II MASTER FUND, LP
		
	By:	 	 /s/ Eric Soderland

	Name: Eric Soderland
	Title: Authorized Signatory

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

			
	HW HEDGED VALUE, LP
	By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name: Anna Marie Lopez
	Title: Chief Operating Officer of H&W

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

 CONSENTING SECOND LIEN PIK NOTEHOLDERS: 

 

			
	MACKAY SHIELDS LLC, an investment subadvisor to the funds denoted on Exhibit B
		
	By:	 	 /s/ Andrew Susser

	Name: Andrew Susser
	Title: Executive Managing Director

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

 
			
	CORRE OPPORTUNITIES QUALIFIED MASTER FUND, LP
		
	By:	 	 /s/ Eric Soderland

		 	Name: Eric Soderland
		 	Title: Authorized Signatory
	
	CORRE OPPORTUNITIES II MASTER FUND, LP
		
	By:	 	 /s/ Eric Soderland

		 	Name: Eric Soderland
		 	Title: Authorized Signatory
	
	CORRE HORIZON INTERIM FUND LLC
		
	By:	 	 /s/ Eric Soderland

		 	Name: Eric Soderland
		 	Title: Authorized Signatory

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

			
	HOTCHKIS AND WILEY HIGH YIELD FUND
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  

			
	SAN DIEGO COUNTY EMPLOYEES RETIREMENT ASSOCIATION
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  

			
	HOTCHKIS AND WILEY CAPITAL INCOME FUND
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  

			
	SANTA BARBARA COUNTY EMPLOYEES RETIREMENT SYSTEM
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  
 [Signature Page to
Amendment No. 1 to Restructuring Support Agreement] 

			
	NATIONAL ELEVATOR INDUSTRY PENSION FUND	  	
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  

			
	TEXAS COUNTY AND DISTRICT RETIREMENT SYSTEM	  	
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  

			
	GOVERNMENT OF GUAM RETIREMENT FUND	  	
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  

			
	UNIVERSITY OF DAYTON	  	
	
	 By: Hotchkis and Wiley Capital Management, LLC (H&W), its investment
manager

  

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

  
 [Signature Page to
Amendment No. 1 to Restructuring Support Agreement] 

 HW HEDGED VALUE, LP 
  

	By:	 Hotchkis and Wiley Capital Management, LLC (H&W), its investment manager 

 

			
	By:	 	 /s/ Anna Marie Lopez

	Name:	 	Anna Marie Lopez
	Title:	 	Chief Operating Officer of H&W

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement] 

 
			
	CROSS SOUND MANAGEMENT LLC,
	As investment advisor for certain funds and accounts
		
	By:	 	 /s/ Helen Lovely Francis

		 	Name: Helen Lovely Francis
		 	Title: COO

 [Signature Page to Amendment No. 1 to Restructuring Support Agreement]

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00290-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00290-of-00352.parquet"}]]