Document:

Exhibit 4.61

 Exhibit 4.61 
 DEBT SECURITIES GUARANTEE AGREEMENT 
 BETWEEN 
 PARTNERRE LTD. 
 (AS GUARANTOR) 
 AND 
 THE BANK OF NEW YORK 
 (AS GUARANTEE TRUSTEE) 
 DATED AS OF 
 May 27, 2008 

 TABLE OF CONTENTS 
  

 

					
	 	 	 	  	 PAGE

	 	 	ARTICLE 1	  	 
	 	 	DEFINITIONS	  	 
	 Section 1.01.
	 	Definitions	  	1
			
		 	ARTICLE 2	  	
		 	TRUST INDENTURE ACT	  	
			
	 Section 2.01.
	 	Trust Indenture Act: Application	  	3
	 Section 2.02.
	 	List of Holders	  	3
	 Section 2.03.
	 	Reports by the Guarantee Trustee	  	4
	 Section 2.04.
	 	Periodic Reports to the Guarantee Trustee	  	4
	 Section 2.05.
	 	Evidence of Compliance with Conditions Precedent	  	4
	 Section 2.06.
	 	Events of Default; Waiver	  	4
	 Section 2.07.
	 	Event of Default; Notice	  	4
	 Section 2.08.
	 	Conflicting Interests	  	5
			
		 	ARTICLE 3	  	
		 	POWERS, DUTIES AND RIGHTS OF GUARANTEE TRUSTEE	  	
			
	 Section 3.01.
	 	Powers, and Duties of the Guarantee Trustee	  	5
	 Section 3.02.
	 	Certain Rights of the Guarantee Trustee	  	7
	 Section 3.03.
	 	Indemnity	  	9
			
		 	ARTICLE 4	  	
		 	GUARANTEE TRUSTEE	  	
			
	 Section 4.01.
	 	Guarantee Trustee; Eligibility	  	9
	 Section 4.02.
	 	Appointment, Removal and Resignation of Guarantee Trustees	  	10
			
		 	ARTICLE 5	  	
		 	GUARANTEE	  	
			
	 Section 5.01.
	 	Guarantee	  	10
	 Section 5.02.
	 	Waiver of Notice and Demand	  	11
	 Section 5.03.
	 	Obligations Not Affected	  	11
	 Section 5.04.
	 	Rights of Holders	  	12
	 Section 5.05.
	 	Guarantee of Payment	  	12
	 Section 5.06.
	 	Subrogation	  	12

					
	Section 5.07.	 	Independent Obligations	  	12
	Section 5.08.	 	Net Payments	  	13
			
		 	ARTICLE 6	  	
		 	LIMITATION OF TRANSACTIONS; RANKING	  	
			
	Section 6.01.	 	Limitation of Transactions	  	14
	Section 6.02.	 	Ranking	  	15
	Section 6.03.	 	Pari Passu Guarantees	  	15
			
		 	ARTICLE 7	  	
		 	TERMINATION	  	
			
	Section 7.01.	 	Termination	  	15
			
		 	ARTICLE 8	  	
		 	MISCELLANEOUS	  	
			
	Section 8.01.	 	Successors and Assigns	  	16
	Section 8.02.	 	Amendments	  	16
	Section 8.03.	 	Notices	  	16
	Section 8.04.	 	Benefit	  	17
	Section 8.05.	 	Governing Law	  	18
	Section 8.06.	 	Interpretation	  	18
	Section 8.07.	 	Submission to Jurisdiction	  	18
	Section 8.08.	 	Judgment Currency	  	19
	Section 8.09.	 	Waiver Of Jury Trial	  	20
	Section 8.10.	 	Force Majeure	  	20

  

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 GUARANTEE AGREEMENT 
 This GUARANTEE AGREEMENT (this “Guarantee Agreement” or this “Guarantee”), dated as of May 27, 2008, is executed and delivered by PartnerRe Ltd., a Bermuda company
(“PartnerRe” or the “Guarantor”), having its principal executive offices at 90 Pitts Bay Road, Pembroke HM 08, Bermuda, and The Bank of New York, a New York banking corporation, having a corporate trust office
located at 101 Barclay Street, Floor 8W, New York, New York 10286, as trustee (the “Guarantee Trustee”), for the benefit of the Holders (as defined herein) from time to time of the Notes (as defined herein) issued by PartnerRe
Finance A LLC, a Delaware limited liability company (the “Issuer”). 
 WHEREAS, pursuant to an Indenture, dated as of
May 27, 2008 (the “Indenture”) among the Issuer, the Guarantor and the Guarantee Trustee, as trustee thereunder, the Issuer may issue senior unsecured debt securities (the “Notes”). 
 WHEREAS, as incentive for the Holders (as defined in the Indenture) to purchase such Notes, the Guarantor desires irrevocably and unconditionally, to
guarantee the obligations of the Issuer under the Indenture. 
 NOW, THEREFORE, in consideration of the purchase and acceptance of the Notes
by the Holders thereof, which purchase the Guarantor hereby agrees shall benefit the Guarantor, the Guarantor executes and delivers this Guarantee Agreement for the benefit of the Holders. 
 ARTICLE 1 
 DEFINITIONS 
 Section 1.01. Definitions. As used in this Guarantee Agreement, the terms set forth below shall, unless the context otherwise requires, have the
following meanings. Capitalized or otherwise defined terms used, but not otherwise defined herein shall have the meanings assigned to such terms in the Indenture as in effect on the date hereof. 
 “Additional Amounts” means any additional amounts which are required hereby or by the terms of the Notes, under circumstances specified
herein or therein, to be paid by the Guarantor in respect of certain taxes, assessments or other governmental charges imposed on Holders specified herein and therein and which are owing to such Holders. 
 “Affiliate” of any specified Person means any other Person directly or indirectly controlling or controlled by or under direct or
indirect common control with such specified Person; provided, however, that an Affiliate of the Guarantor 

 
shall not be deemed to include the Issuer. For the purpose of this definition, “control” when used with respect to any specified Person
means the power to direct the management and policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise; and the terms “controlling” and
“controlled” have meanings correlative to the foregoing. 
 “Authorized Officer” means, when used with
respect to any Person, the Chairman of the Board of Directors, a Vice Chairman, the President, a Vice President, the Chief Financial Officer, the Treasurer, an Assistant Treasurer, the Chief Investment Officer, the Chief Accounting Officer, the
Chief Legal Counsel, the Secretary or an Assistant Secretary, of such Person. 
 “Event of Default” means a default by the
Guarantor on any of its payment or other obligations under this Guarantee Agreement; provided, however, that, except with respect to a payment default, the Guarantor shall have received notice of default and shall not have cured such default
within 60 days after receipt of such notice. 
 “Guarantee Trustee” means The Bank of New York, until a Successor Guarantee
Trustee has been appointed and has accepted such appointment pursuant to the terms of this Guarantee Agreement and thereafter means each such Successor Guarantee Trustee. 
 “Indenture” has the meaning set forth in the preamble hereto. 
 “List of
Holders” has the meaning specified in Section 2.02(a). 
 “Notes” has the meaning set forth in the preamble
hereto. 
 “Officers’ Certificate” means, with respect to any Person, a certificate signed by two Authorized Officers,
at least one of which is a principal executive, principal financial or principal accounting officer, and is delivered to the Guarantee Trustee. Any Officers’ Certificate delivered with respect to compliance with a condition or covenant provided
for in this Guarantee shall include: 
 (a) a statement that each officer signing the Officers’ Certificate has read the covenant or
condition and the definitions relating thereto; 
 (b) a brief statement of the nature and scope of the examination or investigation
undertaken by such officer in rendering the Officers’ Certificate; 
 (c) a statement that such officer has made such examination or
investigation as, in such officer’s opinion, is necessary to enable such officer to express an informed opinion as to whether or not such covenant or condition has been complied with; and 
  

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 (d) a statement as to whether, in the opinion of such officer, such condition or covenant has been
complied with. 
 “Person” means a legal person, including any individual, corporation, estate, partnership, joint venture,
association, joint stock company, limited liability company, trust, unincorporated association or government or any agency or political subdivision thereof, or any other entity of whatever nature. 
 “Responsible Officer” means, with respect to the Guarantee Trustee, any officer of the Guarantee Trustee with direct responsibility for
administration of this Guarantee Agreement and also means, with respect to a particular corporate trust matter, any other officer to whom such matter is referred because of that officer’s knowledge of and familiarity with the particular
subject. 
 “Successor Guarantee Trustee” means a successor Guarantee Trustee possessing the qualifications to act as
Guarantee Trustee under Section 4.01. 
 “Trust Indenture Act” means the Trust Indenture Act of 1939, as amended.

 ARTICLE 2 
 TRUST INDENTURE ACT 
 Section 2.01. Trust Indenture Act: Application.

 (a) This Guarantee Agreement is subject to the provisions of the Trust Indenture Act that are required to be part of this Guarantee
Agreement and shall, to the extent applicable, be governed by such provisions. 
 (b) If and to the extent that any provision of this
Guarantee Agreement limits, qualifies or conflicts with the duties imposed by Sections 310 to 317, inclusive, of the Trust Indenture Act, such imposed duties shall control. 
 Section 2.02. List of Holders. 
 (a)
Within 30 days after the receipt by the Guarantor of a request in writing from the Guarantee Trustee, the Guarantor shall furnish or cause to be furnished to the Guarantee Trustee a list, in such form as the Guarantee Trustee may reasonably require,
of the names and addresses of the Holders (“List of Holders”), such List of Holders to be as of a date not more than 15 days prior to the time such List of Holders is furnished, in each case to the extent such information is in the
possession or control of the Guarantor and is not identical to a previously supplied list of Holders or has not otherwise been received by the Guarantee Trustee in its capacity as such. The Guarantee Trustee may destroy any List of Holders
previously given to it on receipt of a new List of Holders. 
  

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 (b) The Guarantee Trustee shall comply with its obligations under Section 311(a),
Section 311(b) and Section 312(b) of the Trust Indenture Act. 
 Section 2.03. Reports by the Guarantee Trustee. Within 60
days after May 15 of each year commencing with May 15, 2009, the Guarantee Trustee shall provide to the Holders such reports as are required by Section 313 of the Trust Indenture Act, if any, in the form and in the manner provided by
Section 313 of the Trust Indenture Act. The Guarantee Trustee shall also comply with the requirements of Section 313(d) of the Trust Indenture Act. 
 Section 2.04. Periodic Reports to the Guarantee Trustee. The Guarantor shall provide to the Guarantee Trustee, the Securities and Exchange Commission and the Holders, such documents, reports and information, if
any, as required by Section 314 of the Trust Indenture Act and the compliance certificate required by Section 314 of the Trust Indenture Act, in the form, in the manner and at the times required by Section 314 of the Trust Indenture
Act. 
 Section 2.05. Evidence of Compliance with Conditions Precedent. The Guarantor shall provide to the Guarantee Trustee such
evidence of compliance with such conditions precedent, if any, provided for in this Guarantee Agreement that relate to any of the matters set forth in Section 314(c) of the Trust Indenture Act. Any certificate or opinion required to be given by
an officer pursuant to Section 314(c)(1) may be given in the form of an Officers’ Certificate. 
 Section 2.06. Events of
Default; Waiver. The holders of not less than a majority of the outstanding principal amount of the Notes may, by vote, on behalf of all Holders, waive any past Event of Default and its consequences. Upon such waiver, any such Event of Default
shall cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured, for every purpose of this Guarantee Agreement, but no such waiver shall extend to any subsequent or other default or Event of Default or impair any
right consequent thereon. 
 Section 2.07. Event of Default; Notice. 
 (a) The Guarantee Trustee shall, within 90 days after the occurrence of an Event of Default known to the Guarantee Trustee, transmit by mail, first class
postage prepaid, to the Holders, notices of all such Events of Default, unless such defaults have been cured or waived before the giving of such notice, provided, except in the case of a default in the payment by the Guarantor of any amount due
under this Guarantee Agreement, the Guarantee Trustee shall be protected in withholding such notice if and so long as the board of directors, the executive committee or a trust committee of directors and/or Responsible Officers of the Guarantee
Trustee in good faith determines that the withholding of such notice is in the interests of the Holders. 
  

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 (b) The Guarantee Trustee shall not be deemed to have knowledge of any Event of Default unless the
Guarantee Trustee shall have received written notice, or a Responsible Officer of the Guarantee Trustee shall have actual knowledge or shall have obtained written notice, of such Event of Default. 
 Section 2.08. Conflicting Interests. The Indenture shall be deemed to be specifically described in this Guarantee Agreement for the purposes of
clause (i) of the first proviso contained in Section 310(b) of the Trust Indenture Act. 
 ARTICLE 3 
 POWERS, DUTIES AND RIGHTS OF GUARANTEE TRUSTEE

 Section 3.01. Powers, and Duties of the Guarantee Trustee. 
 (a) This Guarantee Agreement shall be held by the Guarantee Trustee for the benefit of the Holders, and the Guarantee Trustee shall not transfer this
Guarantee Agreement to any Person except a Holder exercising his or her rights pursuant to Section 5.04(d) or to a Successor Guarantee Trustee on acceptance by such Successor Guarantee Trustee of its appointment to act as Successor Guarantee
Trustee. The right, title and interest of the Guarantee Trustee shall automatically vest in any Successor Guarantee Trustee, upon acceptance by such Successor Guarantee Trustee of its appointment hereunder, and such vesting and cessation of title
shall be effective whether or not conveyancing documents have been executed and delivered pursuant to the appointment of such Successor Guarantee Trustee. 
 (b) If an Event of Default hereunder or under the Indenture has occurred and is continuing, the Guarantee Trustee shall enforce this Guarantee Agreement for the benefit of the Holders. 
 (c) The Guarantee Trustee, before the occurrence of any Event of Default hereunder or under the Indenture and after the curing or waiver of all Events of
Default that may have occurred, shall undertake to perform only such duties as are specifically set forth in this Guarantee Agreement, and no implied covenants shall be read into this Guarantee Agreement against the Guarantee Trustee. In case an
Event of Default has occurred hereunder or under the Indenture (that has not been cured or waived pursuant to Section 2.06 of this Guarantee Agreement or Section 5.13 of the Indenture), the Guarantee Trustee shall exercise such of the
rights and powers vested in it by this Guarantee Agreement, and use the same degree of care and skill in its exercise thereof, as a prudent person would exercise or use under the circumstances in the conduct of his or her own affairs. 
  

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 (d) No provision of this Guarantee shall be construed to relieve the Guarantee Trustee from liability for
its own negligent action, its negligent failure to act or its own bad faith or willful misconduct, except that: 
 (i) prior
to the occurrence of any Event of Default hereunder or under the Indenture and after the curing or waiving of any such Events of Default that may have occurred: 
 (A) the duties and obligations of the Guarantee Trustee shall be determined solely by the express provisions of this Guarantee Agreement,
and the Guarantee Trustee shall not be liable except for the performance of such duties and obligations as are specifically set forth in this Guarantee Agreement, and 
 (B) in the absence of bad faith on the part of the Guarantee Trustee, the Guarantee Trustee may conclusively rely, as to the truth of the
statements and the correctness of the opinions expressed therein, upon any certificates or opinions furnished to the Guarantee Trustee and conforming to the requirements of this Guarantee Agreement; but in the case of any such certificates or
opinions that by any provision hereof are specifically required to be furnished to the Guarantee Trustee, the Guarantee Trustee shall be under a duty to examine the same to determine whether or not they conform to the requirements of this Guarantee
Agreement; 
 (ii) the Guarantee Trustee shall not be liable for any error of judgment made in good faith by a Responsible
Officer of the Guarantee Trustee, unless it shall be proved that the Guarantee Trustee was negligent in ascertaining the pertinent facts upon which such judgment was made; 
 (iii) the Guarantee Trustee shall not be liable (including, without limitation, for consequential damages) with respect to any action
taken or omitted to be taken by it in good faith in accordance with the direction of the holders of not less than a majority of the outstanding principal amount of the Notes relating to the time, method and place of conducting any proceeding for any
remedy available to the Guarantee Trustee, or exercising any trust or power conferred upon the Guarantee Trustee under this Guarantee Agreement; and 
 (iv) no provision of this Guarantee shall require the Guarantee Trustee to expend or risk its own funds or otherwise incur personal financial liability in the performance of any of its duties or in the exercise

  

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of any of its rights or powers, if the Guarantee Trustee shall have reasonable grounds for believing that the repayment of such funds or liability is not
reasonably assured to it under the terms of this Guarantee Agreement or adequate indemnity against such risk or liability is not reasonably assured to it. 
 Section 3.02. Certain Rights of the Guarantee Trustee. 
 (a) Subject to the provisions of
Section 3.01: 
 (i) The Guarantee Trustee may rely upon, and shall be fully protected in acting or refraining from
acting upon, any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document believed by it to be genuine and to have
been signed, sent or presented by the proper party or parties. 
 (ii) Any direction or act of the Guarantor contemplated by
this Guarantee Agreement shall be sufficiently evidenced by an Officers’ Certificate unless otherwise prescribed herein. 
 (iii) Whenever, in the administration of this Guarantee Agreement, the Guarantee Trustee shall deem it desirable that a matter be proved or established before taking, suffering or omitting any action hereunder, the Guarantee Trustee (unless
other evidence is herein specifically prescribed) may, in the absence of bad faith on its part, request and rely upon an Officers’ Certificate which, upon receipt of such request, shall be promptly delivered by the Guarantor. 
 (iv) The Guarantee Trustee may consult with competent legal counsel, and the written advice or opinion of such counsel with respect to
legal matters shall be full and complete authorization and protection in respect of any action taken, suffered or omitted to be taken by it hereunder in good faith and in accordance with such advice or opinion. Such counsel may be counsel to the
Guarantor or any of its Affiliates and may include any of its employees. The Guarantee Trustee shall have the right at any time to seek instructions concerning the administration of this Guarantee Agreement from any court of competent jurisdiction.

 (v) The Guarantee Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this
Guarantee Agreement at the request or direction of any Holder, unless such Holder shall have provided to the Guarantee Trustee such security and indemnity reasonably satisfactory to the Guarantee Trustee, against the costs, expenses (including
reasonable attorneys’ fees and expenses) and 

  

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liabilities that might be incurred by it in complying with such request or direction, including such reasonable advances as may be requested by the Guarantee
Trustee; provided that, nothing contained in this Section 3.02(a)(v) shall be taken to relieve the Guarantee Trustee, upon the occurrence of an Event of Default hereunder or under the Indenture, of its obligation to exercise the rights
and powers vested in it by this Guarantee Agreement. 
 (vi) The Guarantee Trustee shall not be bound to make any
investigation into the facts or matters stated in any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document, but
the Guarantee Trustee, in its discretion, may make such further inquiry or investigation into such facts or matters as it may see fit. 
 (vii) The Guarantee Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through agents, attorneys, custodians or nominees, and the Guarantee Trustee shall
not be responsible for any misconduct or negligence on the part of any such agent, attorney, custodian or nominee appointed with due care by it hereunder. 
 (viii) Any action taken by the Guarantee Trustee or its agents hereunder shall bind the Holders, and the signature of the Guarantee Trustee or its agents alone shall be sufficient and effective to perform any such
action. No third party shall be required to inquire as to the authority of the Guarantee Trustee to so act or as to its compliance with any of the terms and provisions of this Guarantee Agreement, both of which shall be conclusively evidenced by the
Guarantee Trustee’s or its agent’s taking such action. 
 (ix) Whenever in the administration of this Guarantee
Agreement the Guarantee Trustee shall deem it desirable to receive instructions with respect to enforcing any remedy or right or taking any other action hereunder, the Guarantee Trustee 
 (A) may request instructions from the holders of not less than a majority of the outstanding principal amount of the Notes, 
 (B) may refrain from enforcing such remedy or right or taking such other action until such instructions are received, and 
  

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 (C) shall be protected in acting in accordance with such instructions. 
 (b) No provision of this Guarantee Agreement shall be deemed to impose any duty or obligation on the Guarantee Trustee to perform any act or acts or
exercise any right, power, duty or obligation conferred or imposed on it in any jurisdiction in which it shall be illegal, or in which the Guarantee Trustee shall be unqualified or incompetent in accordance with applicable law, to perform any such
act or acts or to exercise any such right, power, duty or obligation. No permissive power or authority available to the Guarantee Trustee shall be construed to be a duty to act in accordance with such power and authority. 
 Section 3.03. Indemnity. The Guarantor agrees to indemnify the Guarantee Trustee and its officers, directors, employees and agents for, and to
hold them harmless against, any loss, liability or expense incurred without negligence, bad faith or willful misconduct on the part of the Guarantee Trustee, arising out of or in connection with the acceptance or administration of this Guarantee
Agreement, including the costs and expenses of defending itself against any claim or liability in connection with the exercise or performance of any of its powers or duties hereunder and including the reasonable fees and expenses of its counsel. The
Guarantee Trustee will not claim or exact any lien or charge on any other guarantee that may be granted under this Guarantee Agreement as a result of any amount due to it under this Guarantee Agreement. 
 The provisions of this Section 3.03 shall survive the termination of this Guarantee Agreement or the resignation or removal of the Guarantee
Trustee. 
 ARTICLE 4 
 GUARANTEE TRUSTEE 
 Section 4.01. Guarantee Trustee; Eligibility. 
 (a) There shall at all times be a Guarantee Trustee which shall: 
 (i) not be an Affiliate of the Guarantor or the Issuer; and 
 (ii) be a Person that is eligible pursuant to the Trust Indenture Act to act as such and has a combined capital of at least
50 million U.S. dollars ($50,000,000), and shall be a corporation meeting the requirements of Section 310(a) of the Trust Indenture Act. If such corporation publishes reports of condition at least annually, pursuant to law or to the
requirements of the supervising or examining authority, then, for the purposes of this Section 4.01(a)(ii), the combined capital and surplus of such corporation shall be deemed to be its combined capital and surplus as set forth in its most
recent report of condition so published. 
  

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 (b) If at any time the Guarantee Trustee shall cease to be eligible to so act under Section 4.01(a),
the Guarantee Trustee shall immediately resign in the manner and with the effect set out in Section 4.02(c). 
 (c) If the Guarantee
Trustee has or shall acquire any “conflicting interest” within the meaning of Section 310(b) of the Trust Indenture Act, the Guarantee Trustee and Guarantor shall in all respects comply with the provisions of Section 310(b) of
the Trust Indenture Act. 
 Section 4.02. Appointment, Removal and Resignation of Guarantee Trustees. 
 (a) Subject to Section 4.02(b), the Guarantee Trustee may be appointed or removed without cause at any time by the Guarantor. 
 (b) The Guarantee Trustee shall not be removed in accordance with Section 4.02(a) until a Successor Guarantee Trustee has been appointed and has
accepted such appointment by written instrument executed by such Successor Guarantee Trustee and delivered to the Guarantor. 
 (c) The
Guarantee Trustee appointed to office shall hold office until a Successor Guarantee Trustee shall have been appointed or until its removal or resignation. The Guarantee Trustee may resign from office (without need for prior or subsequent accounting)
by an instrument in writing executed by the Guarantee Trustee and delivered to the Guarantor, which resignation shall not take effect until a Successor Guarantee Trustee has been appointed and has accepted such appointment by instrument in writing
executed by such Successor Guarantee Trustee and delivered to the Guarantor and the resigning Guarantee Trustee. 
 (d) If no Successor
Guarantee Trustee shall have been appointed and accepted appointment as provided in this Section 4.02 within 60 days after delivery to the Guarantor of an instrument of resignation, the resigning Guarantee Trustee may petition any court of
competent jurisdiction for appointment of a Successor Guarantee Trustee. Such court may thereupon, after prescribing such notice, if any, as it may deem proper, appoint a Successor Guarantee Trustee. 
 ARTICLE 5 
 GUARANTEE

 Section 5.01. Guarantee. The Guarantor hereby irrevocably and unconditionally guarantees to each Holder the due and punctual
payment of the 

  

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principal of, any premium and interest on, and any Additional Amounts, if applicable, with respect to any Note held by such Holder, when and as the same
shall become due and payable, whether at maturity, by acceleration, redemption, repayment or otherwise, in accordance with the terms of such Note and of the Indenture, and to the Trustee payment of all amounts due to the Trustee relating to the
performance of its duties under the Indenture. The Guarantor further agrees that, as between the Guarantor, on the one hand, and the Holders and the Guarantee Trustee, on the other hand, the maturity of the Notes guaranteed hereby may be accelerated
as provided in Article 5 of the Indenture for the purposes of this Guarantee, notwithstanding any stay, injunction or other prohibition preventing such acceleration in respect of the Notes guaranteed hereby. 
 Section 5.02. Waiver of Notice and Demand. The Guarantor hereby waives notice of acceptance of this Guarantee Agreement and of any liability to
which it applies or may apply, presentment, demand for payment, any right to require a proceeding first against the Guarantee Trustee, the Issuer or any other Person before proceeding against the Guarantor, protest, notice of nonpayment, notice of
dishonor, notice of redemption and all other notices and demands. 
 Section 5.03. Obligations Not Affected. The obligations,
covenants, agreements and duties of the Guarantor under this Guarantee shall be as if it were a principal debtor, and not merely a surety, and shall in no way be affected or impaired by reason of the happening from time to time of any of the
following: 
 (a) the release or waiver, by operation of law or otherwise, of the performance or observance by the Issuer of any express or
implied agreement, covenant, term or condition relating to the Notes to be performed or observed by the Issuer; 
 (b) any failure, omission,
delay or lack of diligence on the part of the Holders to enforce, assert or exercise any right, privilege, power or remedy conferred on the Holders pursuant to the terms of the Notes, or any action on the part of the Issuer granting indulgence or
extension of any kind; 
 (c) the voluntary or involuntary liquidation, dissolution, sale of any collateral, receivership, insolvency,
bankruptcy, assignment for the benefit of creditors, reorganization, arrangement, composition or readjustment of debt of, or other similar proceedings affecting, the Issuer or any of the assets of the Issuer; 
 (d) any invalidity or unenforceability of, or defect or deficiency in, the Notes; or 
 (e) any other circumstance whatsoever that might otherwise constitute a legal or equitable discharge or defense of a guarantor, it being the intent of
this Section 5.03 that the obligations of the Guarantor hereunder shall be absolute and unconditional under any and all circumstances. 
  

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 There shall be no obligation of the Holders to give notice to, or obtain the consent of, the Guarantor
with respect to the happening of any of the foregoing. 
 Section 5.04. Rights of Holders. The Guarantor expressly acknowledges that:
(a) this Guarantee Agreement will be deposited with the Guarantee Trustee to be held for the benefit of the Holders; (b) the Guarantee Trustee has the right to enforce this Guarantee Agreement on behalf of the Holders; (c) the holders
of not less than a majority of the principal amount of the outstanding Notes have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Guarantee Trustee in respect of this Guarantee Agreement or
to direct the exercise of any trust or power conferred upon the Guarantee Trustee under this Guarantee Agreement; and (d) any Holder may, to the extent permitted by law, institute a legal proceeding directly against the Guarantor to enforce its
rights under this Guarantee Agreement, without first instituting a legal proceeding against the Guarantee Trustee, the Issuer or any other Person. The Guarantor waives any right or remedy to require that any action on this Guarantee Agreement be
brought first against the Issuer or any other Person or entity before proceeding directly against the Guarantor. 
 Section 5.05.
Guarantee of Payment. This Guarantee creates a guarantee of payment and not of collection. This Guarantee Agreement will not be discharged except by payment in full of all amounts (without duplication of amounts theretofore paid by the
Issuer) owed under the Notes. 
 Section 5.06. Subrogation. The Guarantor shall be subrogated to all rights, if any, of the Holders
against the Issuer in respect of any amounts paid to such Holders by the Guarantor under this Guarantee Agreement; provided, however, that the Guarantor shall not (except to the extent required by mandatory provisions of applicable law) be
entitled to enforce or exercise any right that it may acquire by way of subrogation or any indemnity, reimbursement or other agreement, in all cases as a result of payment under this Guarantee Agreement, if, at the time of any such payment, any
amounts are due and unpaid under this Guarantee Agreement. If any amount shall be paid to the Guarantor in violation of the preceding sentence, the Guarantor agrees to hold such amount in trust for the Holders and to pay over such amount to the
Holders. 
 Section 5.07. Independent Obligations. The Guarantor acknowledges that its obligations hereunder are independent of the
obligations of the Issuer with respect to the Notes, and that the Guarantor shall be liable as principal and as debtor hereunder to make all payments with respect to the Notes pursuant to the terms of this Guarantee Agreement notwithstanding the
occurrence of any event referred to in subsections (a) through (e), inclusive, of Section 5.03 hereof. 
  

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 Section 5.08. Net Payments. All payments required to be made hereunder shall be made by the
Guarantor without withholding or deduction at source for, or on account of, any present or future taxes, fees, duties, assessments or governmental charges of whatever nature imposed or levied by or on behalf of the Islands of Bermuda or such other
jurisdiction in which the Guarantor (or any of its successors under this Guarantee Agreement) may be organized (each, a “taxing jurisdiction”) or any political subdivision or taxing authority thereof or therein, unless such taxes, fees,
duties, assessments or governmental charges are required to be withheld or deducted by (i) the laws (or any regulations or ruling promulgated thereunder) of a taxing jurisdiction or any political subdivision or taxing authority thereof or
therein or (ii) an official position regarding the application, administration, interpretation or enforcement of any such laws, regulations or rulings (including, without limitation, a holding by a court of competent jurisdiction or by a taxing
authority in a taxing jurisdiction or any political subdivision thereof). If a withholding or deduction at source is required, the Guarantor shall, subject to certain limitations and exceptions set forth below, pay to the Holder of any Note such
Additional Amounts as may be necessary so that every guarantee payment made to such Holder, after such withholding or deduction, shall not be less than the amount provided for in the Indenture and this Guarantee Agreement to be then due and payable;
provided, however, that the Guarantor shall not be required to make payment of such Additional Amounts for or on account of: 
 (1) any tax, fee, duty, assessment or governmental charge of whatever nature which would not have been imposed but for the fact that such Holder: (A) was a resident, domiciliary or national of, or engaged in business or maintained a
permanent establishment or was physically present in, the relevant taxing jurisdiction or any political subdivision thereof or otherwise had some connection with the relevant taxing jurisdiction other than by reason of the mere ownership of, or
receipt of payment under, such Note; (B) presented such Note for payment in the relevant taxing jurisdiction or any political subdivision thereof, unless such Note could not have been presented for payment elsewhere; or (C) presented such
Note more than thirty (30) days after the date on which the payment in respect of such Note first became due and payable or provided for, whichever is later, except to the extent that the Holder would have been entitled to such Additional
Amounts if it had presented such Note for payment on any day within such period of thirty (30) days; 
  

 13 

 (2) any estate, inheritance, gift, sale, transfer, personal property or similar tax,
assessment or other governmental charge; 
 (3) any tax, assessment or other governmental charge that is imposed or withheld
by reason of the failure by the Holder or the beneficial owner of such Note to comply with any reasonable request by the Issuer addressed to the Holder within 90 days of such request (A) to provide information concerning the nationality,
residence or identity of the Holder or such beneficial owner or (B) to make any declaration or other similar claim or satisfy any information or reporting requirement, which, in the case of (A) or (B), is required or imposed by statute,
treaty, regulation or administrative practice of the relevant taxing jurisdiction or any political subdivision thereof as a precondition to exemption from all or part of such tax, assessment or other governmental charge; or 
 (4) any combination of items (1), (2) and (3); nor shall Additional Amounts be paid with respect to any Guarantee Payment to any
Holder who is a fiduciary or partnership or other than the sole beneficial owner of the related Note, but only to the extent such payment would be required by the laws of the relevant taxing jurisdiction (or any political subdivision or relevant
taxing authority thereof or therein) to be included in the income for tax purposes of a beneficiary or partner or settlor with respect to such fiduciary or a member of such partnership or a beneficial owner who would not have been entitled to such
Additional Amounts had it been the Holder of such Note. 
 ARTICLE 6 
 LIMITATION OF TRANSACTIONS; RANKING 
 Section 6.01. Limitation of Transactions. The Guarantor hereby covenants and agrees that, so long as any Notes remain outstanding, it will not, and will not permit any of its Subsidiaries to, (a) declare
or pay any dividends or distributions on, or redeem, purchase, acquire or make a liquidation payment with respect to, any of the outstanding capital shares of the Guarantor or (b) make any payment of principal of, interest or premium, if any,
on or repay, repurchase or redeem any debt security of the Guarantor that ranks equal to or junior in interest 

  

 14 

 
to the Notes or the guarantee in respect thereof, as the case may be, or make any guarantee payments with respect to any guarantee by the Guarantor of the
debt securities of any Subsidiary of the Guarantor if such guarantee ranks equal to or junior in interest to the Notes or the guarantee in respect thereof, as the case may be (other than (i) dividends or distributions in shares of, or options,
warrants, rights to subscribe for or purchase shares of, common shares of the Guarantor, (ii) any declaration of a dividend in connection with the implementation of a stockholder’s rights plan, or the issuance of stock under any such plan
in the future, or the redemption or repurchase of any such rights pursuant thereto, (iii) the purchase of fractional shares resulting from a reclassification of the Guarantor’s capital stock, (iv) the exchange or conversion of any
class or series of the Guarantor’s (or any Subsidiary’s) capital stock for another class or series of the Guarantor’s (or any Subsidiary’s) capital stock or of any class or series of the Guarantor’s (or any
Subsidiary’s) indebtedness, (v) the purchase of fractional interests in shares of the Guarantor’s capital stock pursuant to the conversion or exchange provisions of such capital stock or the security being converted or exchanged; and
(vi) repurchases, redemptions or other acquisitions of shares of capital stock of the Guarantor or any subsidiary under any employment agreement or benefit plan for the benefit of the Guarantor’s directors, officers, or employees, or any
dividend reinvestment or director, officer or employee stock purchase plan of the Guarantor) if at such time (1) there shall have occurred any event of which the Guarantor has actual knowledge that (A) with the giving of notice or the
lapse of time or both, would constitute an Event of Default under the Indenture and (B) in respect of which the Guarantor shall not have taken reasonable steps to cure, or (2) the Guarantor shall be in default with respect to its payment
of any obligations under this Guarantee Agreement. 
 Section 6.02. Ranking. This Guarantee Agreement shall constitute a senior
unsecured obligation of the Guarantor and shall rank equally with all senior unsecured indebtedness of the Guarantor from time to time outstanding. 
 Section 6.03. Pari Passu Guarantees. This Guarantee Agreement shall rank pari passu with any similar guarantee agreements issued by the Guarantor on behalf of holders of senior unsecured notes issued by any entity affiliated
with the Guarantor which is a financing vehicle of the Guarantor. 
 ARTICLE 7 
 TERMINATION 
 Section 7.01. Termination. This Guarantee shall
terminate and be of no further force and effect upon (i) full payment of the Redemption Price of all Notes and all other amounts then due and payable under the Indenture, or (ii) the full payment of the amounts payable in accordance with
the Indenture. Notwithstanding the foregoing, this Guarantee Agreement will continue to be 

  

 15 

 
effective or will be reinstated, as the case may be, if at any time any Holder must restore payment of any sums paid with respect to the Notes or under this
Guarantee Agreement. 
 ARTICLE 8 
 MISCELLANEOUS 
 Section 8.01. Successors and Assigns. All guarantees and agreements contained in this
Guarantee Agreement shall bind the successors, assigns, receivers, trustees and representatives of the Guarantor and shall inure to the benefit of the Holders of the Notes then outstanding. Except in connection with a consolidation, merger, or sale
involving the Guarantor that is permitted under Article 8 of the Indenture and pursuant to which the assignee agrees in writing to perform the Guarantor’s obligations hereunder, the Guarantor shall not assign its obligations hereunder.

 Section 8.02. Amendments. Except with respect to any changes that do not adversely affect the rights of Holders in any material
respect (in which case no consent of Holders will be required) and any changes to Sections 5.01 and Section 6.01 hereof, which may only be amended in writing with the prior approval of each Holder, this Guarantee Agreement may only be amended
in writing by the parties hereto with the prior approval of the holders of not less than a majority of the outstanding principal amount of the Notes. The provisions of Article 15 of the Indenture concerning meetings of Holders apply to the giving of
such approval. 
 Section 8.03. Notices. Any notice, request or other communication required or permitted to be given hereunder shall
be in writing, duly signed by the party giving such notice, and shall be delivered, telecopied or mailed by first class mail, as follows: 
 (a) If given to the Guarantee Trustee, at the Guarantee Trustee’s mailing address set forth below (or such other address as the Guarantee Trustee may give notice of to the Guarantor and the Holders): 
 The Bank of New York 
 101 Barclay Street

 Floor 8W 
 New York, New York
10286 
 Attention: Corporate Trust Administration 
 (b) If given to the Guarantor, at the Guarantor’s mailing address set forth below (or such other address as the Guarantor may give notice of to the Holders): 
 PartnerRe Ltd. 
 90 Pitts Bay Road 

Pembroke HM 08 
 Bermuda 
 Attention: Chief Legal Counsel 
  

 16 

 with a copy to: 
 Davis Polk & Wardwell 
 450 Lexington Avenue 
 New York, New York 10017 
 Attention: Ethan T.
James, Esq. 
 (c) If given to the Issuer, in care of the Guarantee Trustee, at the Issuer’s (and the Guarantee Trustee’s) address
set forth below or such other address as the Guarantee Trustee on behalf of the Issuer may give notice to the Holders: 
 PartnerRe Finance A
LLC 
 c/o PartnerRe Ltd. 
 90
Pitts Bay Road 
 Pembroke HM 08 
 Bermuda 
 Attention: Chief Legal Counsel 
 with a copy to: 
 The Bank of New York 
 101 Barclay Street 
 Floor 8W 
 New York, New York 10286 
 Attention:
Corporate Trust Administration 
 (d) If given to any Holder, at the address set forth on the books and records of the Issuer. 
 All such notices shall be deemed to have been given when received in person, telecopied with receipt confirmed, or mailed by first class mail, postage
prepaid except that if a notice or other document is refused delivery or cannot be delivered because of a changed address of which no notice was given, such notice or other document shall be deemed to have been delivered on the date of such refusal
or inability to deliver. 
 Section 8.04. Benefit. This Guarantee is solely for the benefit of the Holders and is not separately
transferable from the Notes. 
  

 17 

 Section 8.05. Governing Law. THIS GUARANTEE SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN
ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK APPLICABLE TO AGREEMENTS MADE AND PERFORMED IN THAT STATE. 
 Section 8.06.
Interpretation. In this Guarantee, unless the context otherwise requires: 
 (a) capitalized terms used in this Guarantee Agreement,
but not defined in the preamble hereto have the respective meanings assigned to them in Section 1.01 or in the Indenture, as the case may be; 
 (b) a term defined anywhere in this Guarantee Agreement has the same meaning throughout; 
 (c) all references to “the
Agreement” or “this Guarantee Agreement” are to this Guarantee Agreement as modified, supplemented or amended from time to time; 
 (d) all references in this Guarantee Agreement to Articles and Sections are to Articles and Sections of this Guarantee Agreement, unless otherwise specified; 
 (e) a term defined in the Trust Indenture Act has the same meaning when used in this Guarantee Agreement, unless otherwise defined in this Guarantee
Agreement or unless the context otherwise requires; 
 (f) a reference to the singular includes the plural and vice versa; and 
 (g) the masculine, feminine, or neuter genders used herein shall include the masculine, feminine and neuter genders. 
 Section 8.07. Submission to Jurisdiction. The Guarantor agrees that any judicial proceedings instituted in relation to any matter arising under
this Guarantee Agreement may be brought in any United States Federal or New York State court sitting in the Borough of Manhattan, The City of New York, New York to the extent that such court has subject matter jurisdiction over the controversy, and,
by execution and delivery of this Guarantee Agreement, the Guarantor hereby irrevocably accepts, generally and unconditionally, the jurisdiction of the aforesaid courts, acknowledges their competence and irrevocably agrees to be bound by any
judgment rendered in such proceeding. The Guarantor also irrevocably and unconditionally waives for the benefit of the Guarantee Trustee and the Holders any immunity from jurisdiction and any immunity from legal process (whether through service or
notice, attachment prior 

  

 18 

 
to judgment, attachment in the aid of execution, execution or otherwise) in respect of this Guarantee Agreement. The Guarantor hereby irrevocably designates
and appoints, for the benefit of the Guarantee Trustee and the Holders for the term of this Guarantee Agreement, PartnerRe U.S. Corporation, One Greenwich Plaza, Greenwich, CT 06830-6352, as its agent to receive on its behalf service of all process
(with a copy of all such service of process to be delivered to Davis Polk & Wardwell, 450 Lexington Avenue, New York, New York 10017, Attention: Ethan T. James, Esq.) brought against it with respect to any such proceeding in any such court
in The City of New York, such service being hereby acknowledged by the Guarantor to be effective and binding service on it in every respect whether or not the Guarantor shall then be doing or shall have at any time done business in New York. Such
appointment shall be irrevocable so long as any of the Securities or the obligations of the Guarantor hereunder remain outstanding, or until the appointment of a successor located in New York or Connecticut by the Guarantor and such successor’s
acceptance of such appointment. Upon such acceptance, the Guarantor shall notify the Guarantee Trustee in writing of the name and address of such successor. The Guarantor further agrees for the benefit of the Guarantee Trustee and the Holders to
take any and all action, including the execution and filing of any and all such documents and instruments, as may be necessary to continue such designation and appointment of said PartnerRe U.S. Corporation in full force and effect so long as any of
the Notes or the obligations of the Guarantor hereunder shall be outstanding. The Guarantee Trustee shall not be obligated and shall have no responsibility with respect to any failure by the Guarantor to take any such action. Nothing herein shall
affect the right to serve process in any other manner permitted by any law or limit the right of the Guarantee Trustee or any Holder to institute proceedings against the Guarantor in the courts of any other jurisdiction or jurisdictions. 

Section 8.08. Judgment Currency. The Guarantor agrees, to the fullest extent that it may effectively do so under applicable law, that
(a) if for the purpose of obtaining judgment in any court it is necessary to convert the sum due in respect of any guarantee payment (the “Required Currency”) into a currency in which a judgment will be rendered (the
“Judgment Currency”), the rate of exchange used shall be the rate at which in accordance with normal banking procedures the Guarantee Trustee could purchase in The City of New York the requisite amount of the Required Currency with
the Judgment Currency on the New York Banking Day preceding the day on which a final unappealable judgment is given and (b) its obligations under this Guarantee Agreement to make payments in the Required Currency (i) shall not be
discharged or satisfied by any tender, or any recovery pursuant to any judgment (whether or not entered in accordance with clause (a)), in any currency other than the Required Currency, except to the extent that such tender or recovery shall result
in the actual receipt, by the payee, of the full amount of the Required Currency expressed to be payable in respect of such payments, (ii) shall be enforceable as an alternative or 

  

 19 

 
additional cause of action for the purpose of recovering in the Required Currency the amount, if any, by which such actual receipt shall fall short of the
full amount of the Required Currency so expressed to be payable and (iii) shall not be affected by judgment being obtained for any other sum due under this Guarantee Agreement. For purposes of the foregoing, “New York Banking
Day” means any day except a Saturday, Sunday or a legal holiday in The City of New York or a day on which banking institutions in The City of New York are authorized or obligated by law, regulation or executive order to be closed.

 Section 8.09. Waiver Of Jury Trial. EACH OF THE GUARANTOR AND THE GUARANTEE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST
EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS GUARANTEE. 
 Section 8.10. Force Majeure. In no event shall the Guarantee Trustee be responsible or liable for any failure or delay in the performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond
its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions of utilities,
communications or computer (software and hardware) services; it being understood that the Guarantee Trustee shall use reasonable efforts which are consistent with accepted practices in the banking industry to resume performance as soon as
practicable under the circumstances. 
 [THE REST OF THIS PAGE LEFT INTENTIONALLY BLANK] 
  

 20 

 THIS GUARANTEE AGREEMENT is executed as of the day and year first above written. 
  

			
	 PARTNERRE LTD.,
     as
Guarantor

		
	By:	 	 /s/ Albert A. Benchimol

	Name:	 	Albert A. Benchimol
	Title:	 	Executive Vice President and Chief Financial Officer
	
	 THE BANK OF NEW YORK,
     as Guarantee Trustee

		
	By:	 	 /s/ Gregg Weissman

	Name:	 	Gregg Weissman
	Title:	 	Assistant TreasurerThird Amendment to Loan and Security Agreement dated April 6, 2009

 Exhibit 10.1 
 THIRD AMENDMENT 
 TO 
 LOAN AND SECURITY AGREEMENT 
 THIS THIRD AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 6th day of April, 2009, by and
between Silicon Valley Bank (“Bank”) and ARCA biopharma Colorado, Inc. (f/k/a ARCA biopharma, Inc.), a Delaware corporation (“Borrower”) whose address is 8001 Arista Place, Suite 200, Broomfield, CO 80021.

 RECITALS 
 A.
Bank and Borrower have entered into that certain Loan and Security Agreement dated as of July 17, 2007, as amended by a First Amendment, dated January 23, 2009, as amended by a Second Amendment, dated March 23, 2009 (as the same may
from time to time be further amended, modified, supplemented or restated, the “Loan Agreement”). 
 B. Bank has extended
credit to Borrower for the purposes permitted in the Loan Agreement. 
 C. Borrower has requested that Bank amend the Loan Agreement
to revise the maturity date of the outstanding GC Line B Advances. 
 D. Bank has agreed to so amend certain provisions of the Loan
Agreement, but only to the extent, in accordance with the terms, subject to the conditions and in reliance upon the representations and warranties set forth below. 
 AGREEMENT 
 NOW, THEREFORE, in consideration of
the foregoing recitals and other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, and intending to be legally bound, the parties hereto agree as follows: 
 1. Definitions. Capitalized terms used but not defined in this Amendment shall have the meanings given to them in the Loan Agreement. 

2. Amendment to Loan Agreement. The definition of “GC Line B Tranche Two maturity Date” in Section 13.1 of the Loan Agreement is
hereby deleted in its entirety and replaced with the following: 
 “GC Line B Tranche Two Maturity Date” is
April 17, 2009. 
 3. Limitation of Amendment. 
 3.1 The amendment set forth in Section 2, above, is effective for the purposes set forth herein and shall be limited precisely
as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may now have or may have in the
future under or in connection with any Loan Document. 
 3.2 This Amendment shall be construed in connection with and
as part of the Loan Documents and all terms, conditions, representations, warranties, covenants and agreements set forth in the Loan Documents, except as herein amended, are hereby ratified and confirmed and shall remain in full force and effect.

 4. Representations and Warranties. To induce Bank to enter into this Amendment, Borrower hereby
represents and warrants to Bank as follows: 
 4.1 Immediately after giving effect to this Amendment (a) the
representations and warranties contained in the Loan Documents are true, accurate and complete in all material respects as of the date hereof (except to the extent such representations and warranties relate to an earlier date, in which case they are
true and correct as of such date), and (b) no Event of Default has occurred and is continuing; 
 4.2 Borrower has
the power and authority to execute and deliver this Amendment and to perform its obligations under the Loan Agreement, as amended by this Amendment; 
 4.3 The organizational documents of Borrower previously delivered to Bank remain true, accurate and complete and have not been amended, supplemented or restated and are and continue to be in full force and
effect; 
 4.4 The execution and delivery by Borrower of this Amendment and the performance by Borrower of its
obligations under the Loan Agreement, as amended by this Amendment, have been duly authorized; 
 4.5 The execution and
delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement, as amended by this Amendment, do not and will not contravene (a) any law or regulation binding on or affecting Borrower,
(b) any contractual restriction with a Person binding on Borrower, (c) any order, judgment or decree of any court or other governmental or public body or authority, or subdivision thereof, binding on Borrower, or (d) the
organizational documents of Borrower; 
 4.6 The execution and delivery by Borrower of this Amendment and the
performance by Borrower of its obligations under the Loan Agreement, as amended by this Amendment, do not require any order, consent, approval, license, authorization or validation of, or filing, recording or registration with, or exemption by any
governmental or public body or authority, or subdivision thereof, binding on either Borrower, except as already has been obtained or made; and 
 4.7 This Amendment has been duly executed and delivered by Borrower and is the binding obligation of Borrower, enforceable against Borrower in accordance with its terms, except as such enforceability may be
limited by bankruptcy, insolvency, reorganization, liquidation, moratorium or other similar laws of general application and equitable principles relating to or affecting creditors’ rights. 
 5. Counterparts. This Amendment may be executed in any number of counterparts and all of such counterparts taken together shall be deemed to
constitute one and the same instrument. 
 6. Effectiveness. This Amendment shall be deemed effective upon (a) the due execution
and delivery to Bank of this Amendment by each party hereto and (b) Borrower’s payment of all Bank Expenses in connection herewith. 
 [Signature page follows.] 
  

 2 

 IN WITNESS WHEREOF, the parties hereto have caused
this Amendment to be duly executed and delivered as of the date first written above. 
  

									
	BANK:	 		 	BORROWER:
			
	SILICON VALLEY BANK	 		 	ARCA BIOPHARMA COLORADO, INC.
					
	By:	 	/s/ Bret J. Turner	 		 	By:	 	/s/ Patrick Wheeler
	Print Name:	 	Bret J. Turner	 		 	Print Name:	 	Patrick Wheeler
	Title:	 	Relationship Manager	 		 	Title:	 	SVP Finance

  

 3

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