Document:

<PAGE>
                                                                    Exhibit 10.4

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
"SECURITIES ACT"), OR ANY STATE SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED
OR OTHERWISE DISPOSED OF UNLESS REGISTERED UNDER THE SECURITIES ACT AND UNDER
APPLICABLE STATE SECURITIES LAWS OR COMMONWEALTH BIOTECHNOLOGIES, INC. SHALL
HAVE RECEIVED AN OPINION OF ITS COUNSEL THAT REGISTRATION OF SUCH SECURITIES
UNDER THE SECURITIES ACT AND UNDER THE PROVISIONS OF APPLICABLE STATE SECURITIES
LAWS IS NOT REQUIRED.

                           WARRANT TO PURCHASE SHARES

                               OF COMMON STOCK OF

                       COMMONWEALTH BIOTECHNOLOGIES, INC.

                             Expires August 29, 2007

No.: SW-5

Number of Shares: 834

Date of Issuance: August 30, 2002

     FOR VALUE RECEIVED, subject to the provisions hereinafter set forth, the
undersigned, COMMONWEALTH BIOTECHNOLOGIES, INC., a Virginia corporation
(together with its successors and assigns, the "Issuer"), hereby certifies that
James H. Brennan (the "Investor") or its registered assigns is entitled to
subscribe for and purchase, during the period specified in this Warrant, up to
834 shares (subject to adjustment as hereinafter provided) of the duly
authorized, validly issued, fully paid and non-assessable shares of Common Stock
of the Issuer, at an exercise price per share equal to the Warrant Price then in
effect, subject, however, to the provisions and upon the terms and conditions
hereinafter set forth. Capitalized terms used in this Warrant and not otherwise
defined herein shall have the respective meanings specified in Section 8 hereof.

     1. Term. The right to subscribe for and purchase shares of Warrant Stock
represented hereby shall commence on August 30, 2002, and shall expire at 5:00
p.m., eastern time, on August 29, 2007 (such period being the "Term").

     2. Method of Exercise Payment; Issuance of New Warrant; Transfer and
Exchange.

          (a) Time of Exercise.  The purchase rights represented by this Warrant
may be exercised in whole or in part at any time and from time to time during
the Term.

<PAGE>

          (b) Method of Exercise.  This Warrant may be exercised at any time or
from time to time during the Term by surrendering it at the principal office of
the Issuer, at 601 Biotech Drive, Richmond, Virginia 23235, with the
subscription form duly executed, together with payment in an amount equal to the
Warrant Price in effect on the date of such exercise multiplied by the number of
shares of Warrant Stock with respect to which this Warrant is then being
exercised. Payment of this amount may be made (i) by payment in cash or by
corporate check, payable to the order of the Issuer, or (ii) by the Issuer not
issuing that number of shares of Warrant Stock having an aggregate Fair Market
Value equal to such sum, as the Investor may determine. This Warrant may be
exercised for less than the full number of shares of Warrant Stock at the time
called for hereby, except that the number of shares of Warrant Stock receivable
upon exercise of this Warrant as a whole, and the aggregate Warrant Price, shall
be proportionately reduced.

          (c) Issuance of Stock Certificates.  In the event of any exercise of
the rights represented by this Warrant in accordance with and subject to the
terms and conditions hereof, (i) certificates for the shares of Warrant Stock so
purchased shall be dated the date of such exercise and delivered to the Holder
hereof within a reasonable time after such exercise, and the Holder hereof shall
be deemed for all purposes to be the Holder of the shares of Warrant Stock so
purchased as of the date of such exercise, and (ii) unless this Warrant has
expired, a new Warrant representing the number of shares of Warrant Stock, if
any, with respect to which this Warrant shall not then have been exercised shall
also be issued to the Holder hereof at the Issuer's expense within such time.

          (d) Transferability of Warrant.  Subject to Section 2(e), this Warrant
may not be transferred by a Purchaser without the consent of the Issuer, which
consent shall not be unnecessarily withheld. If transferred pursuant to this
paragraph with the consent of the Issuer and subject to the provisions of
subsection (e) of this Section 2, this Warrant may be transferred on the books
of the Issuer by the Holder hereof in person or by duly authorized attorney,
upon surrender of this Warrant at the principal office of the Issuer, properly
endorsed and upon payment of any necessary transfer tax or other governmental
charge imposed upon such transfer. This Warrant is exchangeable at the principal
office of the Issuer for Warrants for the purchase of the same aggregate number
of shares of Warrant Stock, each new Warrant to represent the right to purchase
such number of shares of Warrant Stock as the Holder hereof shall designate at
the time of such exchange. All Warrants issued on transfers or exchanges shall
be dated the Original Issue Date and shall be identical with this Warrant except
as to the number of shares of Warrant Stock issuable pursuant hereto.

          (e) Compliance with Securities Laws.

              (i) The Holder of this Warrant, by acceptance hereof, acknowledges
that this Warrant and the shares of Warrant Stock to be issued upon exercise
hereof are being acquired solely for the Holder's own account and not as a
nominee for any other party, and for investment, and that the Holder will not
offer, sell or otherwise dispose of this Warrant or any shares of Warrant Stock
to be issued upon exercise hereof except pursuant to an effective registration
statement, or an exemption from registration, under the Securities Act and any
applicable state securities laws.

              (ii) Except as provided in paragraph (iii) below, this Warrant and
all certificates representing shares of Warrant Stock issued upon exercise
hereof shall be stamped or imprinted with a legend in substantially the
following form:

                                        2

<PAGE>

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
"SECURITIES ACT"), OR ANY STATE SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED
OR OTHERWISE DISPOSED OF UNLESS REGISTERED UNDER THE SECURITIES ACT AND UNDER
APPLICABLE STATE SECURITIES LAWS OR COMMONWEALTH BIOTECHNOLOGIES, INC. SHALL
HAVE RECEIVED AN OPINION OF ITS COUNSEL THAT REGISTRATION OF SUCH SECURITIES
UNDER THE SECURITIES ACT AND UNDER THE PROVISIONS OF APPLICABLE STATE SECURITIES
LAWS IS NOT REQUIRED.

              (iii) The restrictions imposed by this subsection (e) upon the
transfer of this Warrant or the shares of Warrant Stock to be purchased upon
exercise hereof shall terminate (A) when such securities shall have been resold
pursuant to being effectively registered under the Securities Act, (B) upon the
Issuer's receipt of an opinion of counsel, in form and substance reasonably
satisfactory to the Issuer, addressed to the Issuer to the effect that such
restrictions are no longer required to ensure compliance with the Securities Act
and state securities laws or (C) upon the Issuer's receipt of other evidence
reasonably satisfactory to the Issuer that such registration and qualification
under state securities laws is not required; provided, that the restrictions
imposed by the last sentence of the legend with respect to the transfer of this
Warrant shall not terminate. Whenever such restrictions shall cease and
terminate as to any such securities, the Holder thereof shall be entitled to
receive from the Issuer (or its transfer agent and registrar), without expense
(other than applicable transfer taxes, if any), new Warrants (or, in the case of
shares of Warrant Stock, new stock certificates) of like tenor not bearing the
applicable legend required by paragraph (ii) above relating to the Securities
Act and state securities laws.

     3. Stock Fully Paid; Reservation; Covenants.

          (a) Stock Fully Paid. The Issuer represents, warrants, covenants and
agrees that all shares of Warrant Stock which may be issued upon the exercise of
this Warrant or otherwise hereunder will, upon issuance, be duly authorized,
validly issued, fully paid and non-assessable and free from all taxes, liens and
charges created by or through the Issuer.

          (b) Reservation.  The Issuer further covenants and agrees that during
the period within which this Warrant may be exercised, the Issuer will at all
times have authorized and reserved for the purpose of the issue upon exercise of
this Warrant a sufficient number of shares of Common Stock to provide for the
exercise of this Warrant.

          (c) Covenants.  The Issuer shall not by any action including, without
limitation, amending the Articles of Incorporation or the bylaws of the Issuer,
or through any reorganization, transfer of assets, consolidation, merger,
dissolution, issue or sale of securities or any other action, avoid or seek to
avoid the observance or performance of any of the terms of this Warrant, but
will at all times in good faith assist in the carrying out of all such terms and
in the taking of all such actions as may be necessary or appropriate to protect
the rights of the Holder hereof against dilution (to the extent specifically
provided herein) or impairment. Without limiting the generality of the
foregoing, the Issuer will (i) not permit the par value, if any, of its Common
Stock to exceed the then effective Warrant Price and (ii) take all such action
as may be reasonably necessary in order that the Issuer may validly and legally
issue fully paid and nonassessable shares of Common Stock, free and clear of any
liens, claims, encumbrances and restrictions (other than as provided herein)
upon the exercise of this Warrant.

          (d) Loss, Theft, Destruction of Warrants.  Upon receipt of evidence
satisfactory to the Issuer of the ownership of and the loss, theft, destruction
or mutilation of any Warrant and, in the case of any such loss, theft or
destruction, upon receipt of indemnity or security satisfactory to the Issuer
or, in the case of any such mutilation, upon surrender and

                                       3

<PAGE>

cancellation of such Warrant, the Issuer will make and deliver, in lieu of such
lost, stolen, destroyed or mutilated Warrant, a new Warrant of like tenor and
representing the right to purchase the same number of shares of Common Stock.

     4. Adjustment of Warrant Price and Warrant Share Number. The number and
kind of Securities purchasable upon the exercise of this Warrant and the Warrant
Price shall be subject to adjustment from time to time upon the happening of
certain events as follows:

          (a) Recapitalization, Reorganization, Reclassification, Consolidation,
Merger or Sale.

              (i) In case the Issuer after the Original Issue Date shall do any
of the following (each, a "Triggering Event"): (a) consolidate with or merge
into any other Person and the Issuer shall not be the continuing or surviving
corporation of such consolidation or merger, or (b) permit any other Person to
consolidate with or merge into the Issuer and the Issuer shall be the continuing
or surviving Person but, in connection with such consolidation or merger, any
Capital Stock of the Issuer shall be changed into or exchanged for Securities of
any other Person or cash or any other property, or (c) transfer all or
substantially all of its properties or assets to any other Person, or (d) effect
a capital reorganization or reclassification of its Capital Stock, then, and in
the case of each such Triggering Event, proper provision shall be made so that,
upon the basis and the terms and in the manner provided in this Warrant, the
Holder of this Warrant shall be entitled upon the exercise hereof at any time
after the consummation of such Triggering Event, to the extent this Warrant is
not exercised prior to such Triggering Event, to receive at the Warrant Price in
effect at the time immediately prior to the consummation of such Triggering
Event in lieu of the Common Stock issuable upon such exercise of this Warrant
prior to such Triggering Event, the Securities, cash and property to which such
Holder would have been entitled upon the consummation of such Triggering Event
if such Holder had exercised the rights represented by this Warrant immediately
prior thereto, subject to adjustments (subsequent to such corporate action) as
nearly equivalent as possible to the adjustments provided for in Section 4.

              (ii) Notwithstanding anything contained in this Warrant to the
contrary, the Issuer will not effect any Triggering Event unless, prior to the
consummation thereof, each Person (other than the Issuer) which may be required
to deliver any Securities, cash or property upon the exercise of this Warrant as
provided herein shall assume, by written instrument delivered to, and reasonably
satisfactory to, the Holder of this Warrant, (A) the obligations of the Issuer
under this Warrant (and if the Issuer shall survive the consummation of such
Triggering Event, such assumption shall be in addition to, and shall not release
the Issuer from, any continuing obligations of the Issuer under this Warrant)
and (B) the obligation to deliver to such Holder such shares of Securities, cash
or property as, in accordance with the foregoing provisions of this subsection
(a), such Holder shall be entitled to receive.

          (b) Subdivision or Combination of Shares. If the Issuer, at any time
while this Warrant is outstanding, shall subdivide or combine any shares of
Common Stock, (i) in case of subdivision of shares, the Warrant Price shall be
proportionately reduced (as at the effective date of such subdivision or, if the
Issuer shall take a record of Holders of its Common Stock for the purpose of so
subdividing, as at the applicable record date, whichever is earlier) to reflect
the increase in the total number of shares of Common Stock outstanding as a
result of such subdivision, or (ii) in the case of a combination of shares, the
Warrant Price shall be proportionately increased (as at the effective date of
such combination or, if the Issuer shall take a record of Holders of its Common
Stock for the purpose of so combining, as at the applicable record date,
whichever is earlier) to reflect the reduction in the total number of shares of
Common Stock outstanding as a result of such combination.

                                       4

<PAGE>

          (c) Certain Dividends and Distributions. If the Issuer, at any time
while this Warrant is outstanding, shall pay a dividend in, or make any other
distribution to its stockholders (without consideration therefor) of, shares of
Common Stock, the Warrant Price shall be adjusted, as at the 6 date the Issuer
shall take a record of the Holders of the Issuer's Capital Stock for the purpose
of receiving such dividend or other distribution (or if no such record is taken,
as at the date of such payment or other distribution), to that price determined
by multiplying the Warrant Price in effect immediately prior to such record date
(or if no such record is taken, then immediately prior to such payment or other
distribution), by a fraction (1) the numerator of which shall be the total
number of shares of Common Stock outstanding immediately prior to such record
date (or if no such record date is taken, then immediately prior to such
dividend or distribution), and (2) the denominator of which shall be such number
of shares plus the total number of shares of Common Stock constituting such
dividend or distribution.

          (d) Other Action Affecting Common Stock. In case after the Original
Issue Date the Issuer shall take any action affecting its Common Stock, other
than an action described in any of the foregoing subsections (a) through (f) of
this Section 4, inclusive, and the failure to make any adjustment would not
fairly protect the purchase rights represented by this Warrant in accordance
with the essential intent and principle of this Section 4, then the Warrant
Price shall be adjusted in such manner and at such time as the Board may in good
faith determine to be equitable in the circumstances.

          (e) Adjustment of Warrant Share Number. Upon each adjustment in the
Warrant Price pursuant to any of the foregoing provisions of this Section 4, the
Warrant Share Number shall be adjusted, to the nearest one hundredth of a whole
share, to the product obtained by multiplying the Warrant Share Number
immediately prior to such adjustment in the Warrant Price by a fraction, the
numerator of which shall be the Warrant Price immediately before giving effect
to such adjustment and the denominator of which shall be the Warrant Price
immediately after giving effect to such adjustment. If the Issuer shall be in
default under any provision contained in Section 3 of this Warrant so that
shares issued at the Warrant Price adjusted in accordance with this Section 4
would not be validly issued, the adjustment of the Warrant Share Number provided
for in the foregoing sentence shall nonetheless be made and the Holder of this
Warrant shall be entitled to purchase such greater number of shares at the
lowest price at which such shares may then be validly issued under applicable
law. Such exercise shall not constitute a waiver of any claim arising against
the Issuer by reason of its default under Section 3 of this Warrant.

          (f) Form of Warrant after Adjustments. The form of this Warrant need
not be changed because of any adjustments in the Warrant Price or the number and
kind of Securities purchasable upon the exercise of this Warrant.

     5. Notice of Adjustments. Whenever the Warrant Price or Warrant Share
Number shall be adjusted pursuant to Section 4 hereof (for purposes of this
Section 5, each an "adjustment"), the Issuer shall compute such adjustment and
prepare and execute a certificate setting forth, in reasonable detail, the event
requiring the adjustment, the amount of the adjustment, the method by which such
adjustment was calculated (including a description of the basis on which the
Board made any determination hereunder), and the Warrant Price and Warrant Share
Number after giving effect to such adjustment, and shall cause copies of such
certificate to be delivered to the Holder of this Warrant promptly after each
adjustment.

     6. Fractional Shares. No fractional shares of Warrant Stock will be issued
in connection with and exercise hereof, but in lieu of such fractional shares,
the Issuer shall make a cash payment therefor equal in amount to the product of
the applicable fraction multiplied by the Fair Market Value then in effect.

                                       5

<PAGE>

     7. Definitions. For the purposes of this Warrant, the following terms have
the following meanings:

     "Additional Shares of Common Stock" means all shares of Common Stock issued
by the Issuer after the Original Issue Date, and all shares of Other Common, if
any, issued by the Issuer after the Original Issue Date, except the Warrant
Stock and shares of Common Stock issued upon the exercise of warrants and
options outstanding on the date hereof.

     "Adjustment" shall have the meaning ascribed to it in Section 5 hereof.

     "Articles of Incorporation" means the Articles of Incorporation of the
Issuer as in effect on the Original Issue Date, and as hereafter from time to
time amended, modified, supplemented or restated in accordance with the terms
hereof and thereof and pursuant to applicable law.

     "Board" shall mean the Board of Directors of the Issuer.

     "Capital Stock" means and includes (i) any and all shares, interests,
participations or other equivalents of or interests in (however designated)
corporate stock, including, without limitation, shares of preferred or
preference stock, (ii) all partnership interests (whether general or limited) in
any Person which is a partnership, (iii) all membership interests or limited
liability company interests in any limited liability company, and (iv) all
equity or ownership interests in any Person of any other type.

     "Common Stock" means the Common Stock, without par value per share, of the
Issuer and any other Capital Stock into which such stock may hereafter be
changed.

     "Common Stock Equivalent" means any Convertible Security or warrant, option
or other right to subscribe for or purchase any Additional Shares of Common
Stock or any Convertible Security.

     "Convertible Securities" means evidences of Indebtedness, shares of Capital
Stock or other Securities which are or may be at any time convertible into or
exchangeable for Additional Shares of Common Stock. The term "Convertible
Security" means one of the Convertible Securities.

     "Fair Market Value" means on any particular date (a) the closing bid price
per share of the Common Stock on such date on The Nasdaq National Market, The
Nasdaq SmallCap Market or other registered national stock exchange on which the
Common Stock is then listed or if there is no such price on such date, then the
closing bid price on such exchange or quotation system on the date nearest
preceding such date, or (b) if the Common Stock is not listed then on The Nasdaq
National Market, The Nasdaq SmallCap Market or any registered national stock
exchange, the closing bid price for a share of Common Stock as reported by
NASDAQ or in the National Quotation Bureau Incorporated or similar organization
or agency succeeding to its functions of reporting prices) at the close of
business on such date, or (c) if the Common Stock is not then reported by NASDAQ
or the National Quotation Bureau Incorporated (or similar organization or agency
succeeding to its functions of reporting prices), then the average of the "Pink
Sheet" quotes for the relevant period, as determined in good faith by the
holder, or (d) if the Common Stock is not then publicly traded the fair market
value of a share of Common Stock as determined by an Independent Appraiser
selected by the Issuer; provided, however that all determinations of the Fair
Market Value shall be appropriately adjusted for any stock dividends, stock
splits or other similar transactions during such period. The determination of
fair market value by an Independent Appraiser shall be based upon the fair
market value of the Issuer determined on a going concern basis as between a
willing buyer and a willing seller and taking into account all relevant factors
determinative of value, and shall be final and binding on all

                                       6

<PAGE>

parties. In determining the fair market value of any shares of Common Stock, no
consideration shall be given to any restrictions on transfer of the Common Stock
imposed by agreement or by federal or state securities laws, or to the existence
or absence of, or any limitations on, voting rights.

     "Governmental Authority" means any governmental, regulatory or
self-regulatory entity, department, body, official, authority, commission,
board, agency or instrumentality, whether federal, state or local, and whether
domestic or foreign.

     "Holder" means James H. Brennan.

     "Independent Appraiser" means a nationally recognized or major regional
investment banking firm or firm of independent certified public accountants of
recognized standing (which may be the firm that regularly examines the financial
statements of the Issuer) that is regularly engaged in the business of
appraising the Capital Stock or assets of corporations or other entities as
going concerns, and which is not affiliated with either the Issuer or the Holder
of any Warrant.

     "Investor" shall have the meaning ascribed to it in the recitals of this
Warrant.

     "Issuer" means Commonwealth Biotechnologies, Inc., a Virginia corporation,
and its successors.

     "NASDAQ" means the National Association of Securities Dealers Automated
Quotation System.

     "Original Issue Date" means August 30, 2002.

     "Other Common" means any other Capital Stock of the Issuer of any class
which shall be authorized at any time after the date of this Warrant (other than
Common Stock) and which shall have the right to participate in the distribution
of earnings and assets of the Issuer without limitation as to amount.

     "Person" means an individual, corporation, limited liability company,
partnership, joint stock company, trust, unincorporated organization, joint
venture, Governmental Authority or other entity of whatever nature.

     "Purchase Agreement" shall mean that certain Common Stock and Warrant
Purchase Agreement, dated as of August 1, 2002, by and among the Issuer and the
purchasers indicated on Exhibit A thereto.

     "Securities" means any debt or equity securities of the Issuer, whether now
or hereafter authorized, any instrument convertible into or exchangeable for
Securities or a Security, and any option, warrant or other right to purchase or
acquire any Security. "Security" means one of the Securities.

     "Securities Act" means the Securities Act of 1933, as amended, or any
similar federal statute then in effect.

     "Subsidiary" means any corporation at least 50% of whose outstanding Voting
Stock shall at the time be owned directly or indirectly by the Issuer or by one
or more of its Subsidiaries, or by the Issuer and one or more of its
Subsidiaries.

     "Term" has the meaning specified in Section 1 hereof.

                                       7

<PAGE>

     "Triggering Event" shall have the meaning ascribed to it in Section 4(a)(i)
hereof.

     "Voting Stock", as applied to the Capital Stock of any corporation, means
Capital Stock of any class or classes (however designated) having ordinary
voting power for the election of a majority of the members of the Board of
Directors (or other governing body) of such corporation, other than Capital
Stock having such power only by reason of the happening of a contingency.

     "Warrants" means the Warrants issued and sold pursuant to the Purchase
Agreement, including, without limitation, this Warrant, and any other warrants
of like tenor issued in substitution or exchange for any thereof pursuant to the
provisions of Section 2(c), 2(d) or 2(e) hereof or of any of such other
Warrants.

     "Warrant Price" means initially $0.90.

     "Warrant Share Number" means at any time the aggregate number of shares of
Warrant Stock which may at such time be purchased upon exercise of this Warrant,
after giving effect to all prior adjustments and increases to such number made
or required to be made under the terms hereof.

     "Warrant Stock" means Common Stock issuable upon exercise of this Warrant.

     9. Other Notices. In case at any time:

          (a) the Issuer shall make any distributions to the holders of Common
Stock; or

          (b) the Issuer shall authorize the granting to all holders of its
Common Stock of rights to subscribe for or purchase any shares of Capital Stock
of any class or of any Common Stock Equivalents or Convertible Securities or
other rights; or

          (c) there shall be any reclassification of the Capital Stock of the
Issuer; or

          (d) there shall be any capital reorganization by the Issuer; or

          (e) there shall be any (i) consolidation or merger involving the
Issuer or (ii) sale, transfer or other disposition of all or substantially all
of the Issuer's property, assets or business (except a merger or other
reorganization in which the Issuer shall be the surviving corporation and its
shares of Capital Stock shall continue to be outstanding and unchanged and
except a consolidation, merger, sale, transfer or other disposition involving a
wholly-owned Subsidiary); or

          (f) there shall be a voluntary or involuntary dissolution, liquidation
or winding-up of the Issuer or any partial liquidation of the Issuer or
distribution to holders of Common Stock;

then, in each of such cases, the Issuer shall give written notice to the Holder
of the date on which (i) the books of the Issuer shall close or a record shall
be taken for such dividend, distribution or subscription rights or (ii) such
reorganization, reclassification, consolidation, merger, disposition,
dissolution, liquidation or winding-up, as the case may be, shall take place.
Such notice also shall specify the date as of which the holders of Common Stock
of record shall participate in such dividend, distribution or subscription
rights, or shall be entitled to exchange their certificates for Common Stock for
securities or other property deliverable upon such reorganization,
reclassification, consolidation, merger, disposition, dissolution, liquidation
or winding-up, as the case may be. Such notice shall be given at least twenty
days prior to the action in question and

                                       8

<PAGE>

not less than twenty days prior to the record date or the date on which the
Issuer's transfer books are closed in respect thereto.

     10. Amendment and Waiver. Any term, covenant, agreement or condition in
this Warrant may be amended, or compliance therewith may be waived (either
generally or in a particular instance and either retroactively or
prospectively), by a written instrument or written instruments executed by the
Issuer and the Holder; provided, however, that no such amendment or waiver shall
reduce the Warrant Share Number, increase the Warrant Price, shorten the period
during which this Warrant may be exercised or modify any provision of this
Section 10 without the consent of the Holder of this Warrant.

     11. Governing Law. THIS WARRANT SHALL BE GOVERNED BY AND CONSTRUED IN
ACCORDANCE WITH THE LAWS OF THE COMMONWEALTH OF VIRGINIA, WITHOUT GIVING EFFECT
TO PRINCIPLES OF CONFLICTS OF LAW.

     12. Notices. Any and all notices or other communications or deliveries
required or permitted to be provided hereunder shall be in writing and shall be
deemed given and effective on the earlier of (i) the date of transmission, if
such notice or communication is delivered via facsimile at the facsimile
telephone number specified for notice prior to 5:00 p.m., eastern standard time,
on a Business Day, (ii) the Business Day after the date of transmission, if such
notice or communication is delivered via facsimile at the facsimile telephone
number specified for notice later than 5:00 p.m., eastern standard time, on any
date and earlier than 11:59 p.m., eastern standard time, on such date, (iii) the
Business Day following the date of mailing, if sent by nationally recognized
overnight courier service or (iv) actual receipt by the party to whom such
notice is required to be given. The addresses for such communications shall be
with respect to the Holder of this Warrant or of Warrant Stock issued pursuant
hereto, addressed to such Holder at its last known address or facsimile number
appearing on the books of the Issuer maintained for such purposes, or with
respect to the Issuer, addressed to: Commonwealth Biotechnologies, Inc., 601
Biotech Drive, Richmond, Virginia 23235 Attention: Robert B. Harris, Ph.D.,
President and Chief Executive Officer or to such other address or addresses or
facsimile number or numbers as any such party may most recently have designated
in writing to the other parties hereto by such notice.

     13. Warrant Agent. The Issuer may, by written notice to each Holder of this
Warrant, appoint an agent for the purpose of issuing shares of Warrant Stock on
the exercise of this Warrant pursuant to subsection (b) of Section 2 hereof,
exchanging this Warrant pursuant to subsection (d) of Section 2 hereof or
replacing this Warrant pursuant to subsection (d) of Section 3 hereof, or any of
the foregoing, and thereafter any such issuance, exchange or replacement, as the
case may be, shall be made at such office by such agent.

     14. Remedies. The Issuer stipulates that the remedies at law of the Holder
of this Warrant in the event of any default or threatened default by the Issuer
in the performance of or compliance with any of the terms of this Warrant are
not and will not be adequate and that, to the fullest extent permitted by law,
such terms may be specifically enforced by a decree for the specific performance
of any agreement contained herein or by an injunction against a violation of any
of the terms hereof or otherwise.

     15. Successors and Assigns. This Warrant and the rights evidenced hereby
shall inure to the benefit of and be binding upon the successors and assigns of
the Issuer, the Holder hereof and shall be enforceable by any such Holder.

     16. Modification and Severability. If, in any action before any court or
agency legally empowered to enforce any provision contained herein, any
provision hereof is found to be unenforceable, then such provision shall be
deemed modified to the extent necessary to make

                                       9

<PAGE>

it enforceable by such court or agency. If any such provision is not enforceable
as set forth in the preceding sentence, the unenforceability of such provision
shall not affect the other provisions of this Warrant, but this Warrant shall be
construed as if such unenforceable provision had never been contained herein.

     17. Headings. The headings of the Sections of this Warrant are for
convenience of reference only and shall not, for any purpose, be deemed a part
of this Warrant.

                                       10

<PAGE>

     IN WITNESS WHEREOF, the Issuer has executed this Warrant as of the day and
year first above written.

                                       COMMONWEALTH BIOTECHNOLOGIES, INC.

                                       By: /s/ Robert B. Harris, Ph.D.
                                           -------------------------------------
                                           President and Chief Executive Officer

                                       11

<PAGE>

                                  EXERCISE FORM

                           , pursuant to the provisions of the within Warrant,
--------------------------
hereby elects to purchase         shares of Common Stock of Commonwealth
                          -------
Biotechnologies, Inc. covered by the within Warrant.

Dated:
       ----------------------------------------------

Signature:
           ------------------------------------------

Address:
          -------------------------------------------

FOR USE BY THE ISSUER ONLY: This Warrant No. SW-   canceled (or transferred or
                                                --
exchanged) this       day of            ,     , shares of Common Stock issued
                -----        ----------   ---
therefor in the name of                             , Warrant No. SW-
                        ---------------------------                   --
issued for         shares of Common Stock in the name of                       .
           -------                                       ----------------------

                                       12<PAGE>

                                [MATRIXONE LOGO]

                                                                   EXHIBIT 10.28

December 3, 2001

Don Hunt
105 Reservation Road
Andover, MA 01810

Dear Don:

I am very pleased to offer you the opportunity to work as an employee at-will of
MatrixOne, Inc. ("the Company") as Senior Vice President, Worldwide Field
Operations reporting to Mark O'Connell, President & CEO. Your starting salary
for this exempt position will be $9615.39 bi-weekly, which is equivalent to
$250,000.00 per year. Your start date will be December 3, 2001; working from our
Westford, MA office.

You will also be eligible to participate in the MatrixOne Executive Sales
Incentive Compensation Plan that is valued at approximately $150,000.00 on
annual basis.

Your On Target Earnings are $400,000.00 on an annual basis. The Company agrees
that for the period beginning on the Start Date and ending on June 30, 2002 (the
end of fiscal year 2002) the Company shall pay you at the rate of your On Target
Earnings on a prorated basis. Thereafter, the payment of your incentive
compensation shall not be guaranteed but shall depend on your achievement of
targets set by the Company subject to the terms and conditions of the Sales
Incentive Compensation Plan. The details of your incentive compensation for
fiscal year 2003 will be determined by the Company at the end of the current
fiscal year.

Subject to the approval of the Company's Board of Directors (the "Board"), you
will be granted the option to purchase 450,000 shares of Company common stock,
at a price equal to the fair market value on the date of the grant. The options
will be subject to and governed by the terms and conditions of a stock option
agreement between you and the Company and the Company's 1996 and 1999 Stock
Plans. 50,000 of these stock options will vest immediately on December 3, 2001.
The remaining 400,000 stock options will vest quarterly and will be 100% vested
at the completion of a four-year period.

MatrixOne, Inc. offers a comprehensive insurance program designed to provide
protection for its employees and their families. The package includes Basic
Life, Accidental Death and Dismemberment, Medical, Dental, Vision, Short and
Long Term Disability. You are also eligible to participate in the Section 105
executive reimbursement health plan. In addition, the Company also provides a
401(K) Retirement Savings Plan, Stock Purchase Plan and four weeks of vacation
per year.

<PAGE>

                                [MATRIXONE LOGO]

Lastly, the Company agrees that, in the event your at-will employment is
terminated for any reason by the Company, you will be paid severance at the rate
of your On-Target Earnings for the period of twelve months immediately following
the date of your termination (the " Severance Period"). If you are employed in
any capacity, or engaged as a consultant, by another individual or entity at any
time during the Severance Period, then the Company will pay you at the rate of
fifty percent of your On Target Earnings for the remainder of the Severance
Period. All severance payments shall be paid in accordance with the Company's
normal payroll practice and shall be conditioned upon your execution of a
release agreement in a form acceptable to the Company as well as your continued
compliance with the post-employment covenants contained in the Employee Secrecy,
Invention and Non-compete Agreement.

As a condition of this offer you will be required to read and acknowledge the
enclosed Employee Secrecy, Invention and Non-Compete Agreement. By signing this
document you agree that your employment shall not cause you to use, distribute
or in any other way disclose confidential or proprietary information or material
from your employer or any third party.

Don, it is a pleasure to welcome you to the MatrixOne team. If you are in
agreement with this offer, please sign the original and return it with the
Employee Secrecy and Non-Compete Agreement in the enclosed envelope to my home
office attn: Jane Seitz, 23 Pembroke Way, Bedford, NH 03110. In addition, you
may also fax your signed offer letter to my confidential home office fax (603)
472-8778. Please do not hesitate to contact me at the office: (978) 589-4229,
home: (603) 472-4474 or mobile: (617) 513-5331 if you have any questions
regarding this offer.

This offer will remain in effect until the close of business on December 3,
2001.

Sincerely,

/s/ Jane Seitz
-----------------
Jane Seitz,
Vice President, Human Resources

Enclosures

Offer accepted by:         /s/ Donald W. Hunt           12-3-01
                           --------------------         -----------------
                           Signature                    Date

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00043-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00043-of-00352.parquet"}]]