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                                                                    Exhibit 10.6

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                 (AMENDED AND RESTATED EFFECTIVE JUNE 27, 2006)

     1. OBJECTIVES. The PICIS, Inc. 2000 Stock Option Plan is designed to
attract and retain certain selected officers, key employees, non-employee
directors and consultants whose skills and talents are important to the
Company's operations, and reward them for making major contributions to the
success of the Company. These objectives are accomplished by making awards under
the Plan, thereby providing Participants with a proprietary interest in the
growth and performance of the Company.

     2. DEFINITIONS.

            (a) "Award" shall mean the grant of a Stock Option to a Plan
     Participant pursuant to such terms, conditions, performance requirements,
     and limitations as the Committee may establish in order to fulfill the
     objectives of the Plan.

            (b) "Award Agreement" shall mean an agreement between PICIS, Inc.
     and a Participant that sets forth the terms, conditions, performance
     requirements, and limitations applicable to an Award.

            (c) "Board" shall mean the Board of Directors of PICIS, Inc.

            (d) "Cause shall mean, with respect to any Participant, one of the
     following:

                     (i)  Cause shall have the meaning assigned to such term in
            an employment agreement in effect between the Company and a
            Participant; or

                     (ii) If 2(d)(i), above, is not applicable, Cause shall have
            the meaning assigned to that term under any statute which governs a
            Participant's employment with the Company; or

                     (iii) If neither 2(d)(i) nor 2(d)(ii), above, are
            applicable, Cause shall mean termination of a Participant's
            employment with the Company or service as a director for (a) any
            failure of the Participant to substantially perform his duties with
            the Company (other than by reason of illness) which occurs after the
            Company has delivered to the Participant a demand for performance
            which specifically identifies the manner in which the Company
            believes the Participant has failed to perform his duties, and the
            Participant fails to resume performance of his duties on a
            continuous basis within 14 days after receiving such demand, (b) the
            commission by the Participant of any act of dishonesty or disloyalty
            involving the Company or its business, or (c) the conviction of the
            Participant of a felony or misdemeanor which, in the reasonable
            judgment of the Committee, is

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            substantially related to the employee's position with the Company or
            substantially impairs the Participant's ability to perform his
            duties with the Company.

            (e) "Change in Control" shall mean any of the following events:

                     (i)  the acquisition by an individual, entity or group
            (within the meaning of Section 13(d)(2) of the Securities Exchange
            Act of 1934, as amended (the "Exchange Act")), (a "Person"), after
            the date hereof, of beneficial ownership (within the meaning of Rule
            13d-3 promulgated under the Exchange Act) of 35% or more of either
            (a) the then outstanding shares of common stock of PICIS, Inc. (the
            "Outstanding Company Common Stock") plus the then outstanding shares
            of preferred stock of PICIS, Inc., on an as converted basis or (b)
            the combined voting power of the then outstanding voting securities
            of PICIS, Inc. entitled to vote generally in the election of
            directors (the "Outstanding Company Voting Securities"); provided,
            however, that for purposes of this subsection (i), the following
            acquisitions shall not constitute a Change of Control: (a) any
            acquisition directly from PICIS, Inc., (b) any acquisition by the
            Company, (c) any acquisition by any employee benefit plan (or
            related trust) sponsored or maintained by the Company, or (d) any
            acquisition by any corporation pursuant to a transaction which
            complies with clauses (a), (b) and (c) of subsection (iii) of this
            Section 2(e); and provided, further, that for purposes of this
            subsection and subsection (iii), below, none of the stockholders of
            PICIS, Inc., and/or any person who becomes a stockholder of PICIS,
            Inc. in the private placement being conducted by PICIS, Inc.,
            concurrently herewith shall be aggregated and treated as members of
            a group constituting a single "Person"; or

                     (ii) individuals who, as of the date hereof, constitute the
            Board (the "Incumbent Board") cease for any reason to constitute at
            least a majority of the Board; provided, however, that any
            individual becoming a director subsequent to the date hereof whose
            election, or nomination for election by PICIS, Inc.'s shareholders,
            was approved by a vote of at least a majority of the directors then
            constituting the Incumbent Board shall be considered as though such
            individual were a member of the Incumbent Board, but excluding, for
            this purpose, any such individual whose initial assumption of office
            occurs as a result of an actual or threatened election contest with
            respect to the election or removal of directors or other actual or
            threatened solicitation of proxies or consents by or on behalf of a
            person other than the Board; or

                     (iii) consummation of a reorganization, merger or
            consolidation or sale or other disposition of all or substantially
            all of the assets of the Company for which approval of the
            shareholders of PICIS, Inc. is required (a "Business Combination"),
            in each case, unless, immediately following such Business
            Combination, (a) all or substantially all of the individuals and
            entities who were the beneficial owners, respectively, of the
            Outstanding Company Common Stock and Outstanding Company Voting
            Securities immediately prior to such Business

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            Combination beneficially own, directly or indirectly, more than 60%
            of, respectively, the then outstanding shares of common stock and
            the combined voting power of the then outstanding voting securities
            entitled to vote generally in the election of directors, as the case
            may be, of the corporation resulting from such Business Combination
            (including, without limitation, a corporation which as a result of
            such transaction owns PICIS, Inc. or all or substantially all of the
            Company's assets either directly or through one or more
            subsidiaries) in substantially the same proportions as their
            ownership, immediately prior to such Business Combination of the
            Outstanding Company Common Stock and Outstanding Company Voting
            Securities, as the case may be, (b) no Person (excluding any
            employee benefit plan (or related trust) of the Company or such
            corporation resulting from such Business Combination) beneficially
            owns, directly or indirectly, 35% or more of, respectively, the then
            outstanding common stock of the corporation resulting from such
            Business Combination or the combined voting power of the then
            outstanding voting securities of such corporation except to the
            extent that such ownership existed prior to the Business Combination
            and (c) at least a majority of the members of the Board of Directors
            of the corporation resulting from such Business Combination were
            members of the Incumbent Board at the time of the execution of the
            initial agreement, or of the action of the Board, providing for such
            Business Combination; or

                     (iv) approval by the shareholders of PICIS, Inc. of a
            complete liquidation or dissolution of PICIS, Inc.

     Notwithstanding the foregoing, in no event will an initial public offering
     of the stock of the Company constitute a Change in Control.

            (f) "Common Stock" shall mean the authorized and issued or unissued
     $.01 par value common stock of PICIS, Inc.

            (g) "Code" shall mean the Internal Revenue Code of 1986, as amended
     from time to time.

            (h) "Committee" shall mean the compensation committee of the Board
     which shall be comprised of at least two non-employee directors or, if
     there is no such committee, the Board.

            (i) "Company" shall mean PICIS, Inc. and its subsidiaries including
     subsidiaries of subsidiaries and partnerships and other business ventures
     in which PICIS, Inc. has a significant equity interest, as determined in
     the sole discretion of the Committee.

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            (j) "Fair Market Value" shall mean, as of any date, the value of
     Common Stock determined as follows:

                     (i)  If the Common Stock is listed on any established stock
            exchange or national market system, its Fair Market Value shall be
            the closing sales price for such stock (or the closing bid, if no
            sales were reported) as quoted on such exchange or system for the
            last market trading day prior to the time of determination, as
            reported in THE WALL STREET JOURNAL or such other source as the
            Committee deems reliable.

                     (ii) If the Common Stock is regularly quoted by a
            recognized securities dealer but selling prices are not reported,
            its Fair Market Value shall be the mean between the high bid and low
            asked prices for the Common Stock on the last market trading day
            prior to the day of determination; or

                     (iii) In the absence of an established market for the
            Common Stock, the Fair Market Value thereof shall be determined in
            good faith by the Committee, with the Committee's determination
            being binding on the Company and the Participants for all purposes.

            (k) "Participant" shall mean a current or prospective employee,
     non-employee director, consultant or other person who provides services to
     the Company to whom an Award has been made under the Plan.

            (l) "Plan" shall mean the PICIS, Inc. 2000 Stock Option Plan.

            (m) "Retirement" shall mean termination of employment with the
     Company or service as a member of the Board on or after the attainment of
     age 65 or such other time as the Committee shall provide.

            (n) "Stock Option" shall mean a grant of a right to purchase a
     specified number of shares of Common Stock, the purchase price of which
     shall be determined by the Committee. A stock option may be in the form of
     a nonqualified stock option or an incentive stock option ("ISO"). A
     nonqualified stock option is an option that does not meet the criteria of
     an ISO. An ISO, in addition to being subject to applicable terms,
     conditions and limitations established by the Committee, complies with
     Section 422 of the Code which, among other limitations, provides that the
     aggregate Fair Market Value (determined at the time the option is granted)
     of Common Stock for which ISOs are exercisable for the first time by a
     Participant during any calendar year shall not exceed $100,000; that ISOs
     shall be priced at not less than 100% of the Fair Market Value on the date
     of the grant (110% in the case of a Participant who is a 10% shareholder of
     the Company within the meaning of Section 422 of the Code); and that ISOs
     shall be exercisable for a period of not more than ten years (five years in
     the case of a Participant who is a 10% shareholder of the Company).

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     3. ELIGIBILITY. Current and prospective employees, non-employee
directors, consultants or other persons who provide services to the Company
eligible for an Award under the Plan are those who hold, or will hold, positions
of responsibility and whose performance, in the judgment of the Committee or the
management of the Company (if such responsibility is delegated pursuant to
Section 6 hereof), can have a significant effect on the success of the Company.
However, incentive stock options within the meaning of Section 422 of the Code
may only be issued to employees of the Company and its subsidiary corporations
within the meaning of Section 424(f) of the Code.

     4. COMMON STOCK AVAILABLE FOR AWARDS. Subject to adjustment as provided
in Section 14 hereof, the number of shares that may be issued under the Plan for
Awards during the term of the Plan is 3,731,300 shares of Common Stock, all of
which may be in the form of incentive stock options. Any shares subject to an
Award which are used, with the Company's consent, in settlement of tax
withholding obligations shall be deemed not to have been issued for purposes of
determining the maximum number of shares available for issuance under the Plan.
Likewise, if any Stock Option is exercised by tendering shares, either actually
or by attestation, to the Company as full or partial payment for such exercise
under this Plan, only the number of shares issued net of the shares tendered
shall be deemed issued for purposes of determining the maximum number of shares
available for issuance under the Plan. No individual shall be eligible to
receive Awards aggregating more than 300,000 shares of Common Stock reserved
under the Plan in any one calendar year, subject to adjustment as provided in
Section 13 hereof.

     5. ADMINISTRATION. The Plan shall be administered by the Committee, which
shall have full and exclusive power to interpret the Plan, to determine which
current and prospective employees, non-employee directors and consultants are
Plan Participants, to grant waivers of Award restrictions, to determine the
provisions of Award Agreements and to adopt such rules, regulations and
guidelines for carrying out the Plan as it may deem necessary or proper, all of
which powers shall be executed in the best interests of the Company and in
keeping with the objectives of the Plan. All decisions of the Committee shall be
final, conclusive and binding on all persons, including the Company,
Participants, and their estates and beneficiaries.

     6. DELEGATION OF AUTHORITY. Except to the extent prohibited by applicable
law or the applicable rules of a stock exchange, the Committee may delegate to
the chief executive officer and to other senior officers of the Company its
duties under the Plan pursuant to such conditions or limitations as the
Committee may establish. Any such delegation may be revoked by the Committee at
any time.

     7. AWARDS. The Committee shall set forth in the related Award Agreement
the terms, conditions, and limitations applicable to each Award including, but
not limited to, continuous service with the Company, and conditions under which
acceleration of vesting will occur.

     8. STOCK OPTION EXERCISE. The price at which shares of Common Stock may
be purchased under a Stock Option shall be paid in full at the time of the
exercise in cash or by any other means permitted by the Committee, including by
means of tendering shares of Common Stock, which have been held by the
Participant for more than six months and have not been used

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within the prior six-month period to exercise an option, either directly or by
attestation, valued at Fair Market Value on the date of exercise, or any
combination thereof.

     9. TAX WITHHOLDING. The Company may defer making delivery with respect to
Common Stock obtained pursuant to the exercise of an Award hereunder until the
Participant has paid to the Company an amount equal to any income or employment
tax withholding amounts imposed on current or former employees as a result of
the exercise of the Award. If the Committee allows Common Stock to be used to
satisfy any such tax withholding obligations, such stock shall be valued based
on the Fair Market Value when the tax withholding is required to be made.

     10. AMENDMENT OR TERMINATION OF THE PLAN. The Board may, at any time, amend
or terminate the Plan; provided, however, that

            (a) subject to Section 13 hereof, no amendment or termination may,
     in the absence of written consent to the change by the affected Participant
     (or, if the Participant is not then living, the affected beneficiary),
     adversely affect the rights of any Participant or beneficiary under any
     Award granted under the Plan prior to the date such amendment is adopted by
     the Board; and

            (b) without further approval of the shareholders of the Company, no
     amendment shall increase the number of shares of Common Stock which may be
     delivered pursuant to Awards hereunder, except for increases resulting from
     Section 13 hereof.

     11. TERMINATION OF SERVICE. If the employment of a Participant terminates,
or a non-employee director no longer serves on the Board, all unvested Awards
shall immediately terminate and all vested but unexercised, deferred or unpaid
Awards shall terminate 90 days after such termination of employment or service,
except as provided in paragraphs 11 (a) and (b), below, and during such 90-day
period shall be exercisable only to the extent provided in the Award Agreement.
Notwithstanding the foregoing, the Committee may provide in an Award Agreement
that if a Participant's employment is terminated for Cause, to the extent the
Award is not effectively exercised or has not vested prior to such termination,
it shall lapse or be forfeited to the Company immediately upon termination. In
all events, an Award will not be exercisable after the end of its term as set
forth in the Award Agreement.

            (a) RETIREMENT. When a Participant's employment or service
     terminates as a result of Retirement, or early retirement with the consent
     of the Committee, the Committee (in the form of an Award Agreement or
     otherwise) may permit Awards to continue in effect beyond the date of
     Retirement, or early retirement, and/or the exercisability and vesting of
     any Award may be accelerated.

            (b) DEATH OR DISABILITY OF A PARTICIPANT.

                     (i)  In the event of a Participant's death, the
            Participant's estate or beneficiaries shall have a period of six (6)
            months (unless otherwise specified in his Award Agreement) within
            which to exercise any outstanding Award held by

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            the Participant under such terms, and to the extent, as may be
            specified in the applicable Award Agreement. Rights to any such
            outstanding Awards shall pass by will or the laws of descent and
            distribution. Subject to subparagraph (iii) below, Awards so passing
            shall be exercised at such times and in such manner as if the
            Participant were living.

                     (ii) In the event a Participant is deemed by the Company to
            have suffered a long-term disability within the meaning of the
            long-term disability coverage which the Company provides to its
            employees, or if there is no such coverage, a total and permanent
            disability (a "Disability"), the Award shall be exercisable pursuant
            to the terms of the applicable Award Agreement and for a period of
            six (6) months (unless otherwise specified in his Award Agreement).
            Awards may be exercised by the Participant, if legally competent, or
            a legally designated guardian or representative if the Participant
            is legally incompetent by virtue of such Disability.

                     (iii) After the death or Disability of a Participant, the
            Committee may in its sole discretion at any time (1) terminate
            restrictions in Award Agreements and (2) accelerate any or all
            installments and rights.

                     (iv) In the event of uncertainty as to interpretation of or
            controversies concerning this paragraph (b) of Section 11, the
            Committee's determinations shall be binding and conclusive.

            (c) NO EMPLOYMENT RIGHTS. The Plan shall not confer upon any
     Participant any right with respect to continuation of employment by the
     Company or service on the Board, nor shall it interfere in any way with the
     right of the Company to terminate any Participant's employment or service
     on the Board at any time.

     12. NONASSIGNABILITY. Except as provided in subsection (b) of Section 11
and this Section 12, no Award under the Plan shall be assignable or
transferable, or exercisable by anyone other than the Participant to whom it was
granted. Notwithstanding the foregoing, the Committee (in the form of an Award
Agreement or otherwise) may permit Awards, other than incentive stock options
within the meaning of Section 422 of the Code, to be transferred to members of
the Participant's immediate family, to trusts for the benefit of the Participant
and/or such immediate family members, and to partnerships or other entities in
which the Participant and/or such immediate family members own all the equity
interests. For purposes of the preceding sentence, "immediate family" shall mean
a Participant's spouse, issue, and spouses of his issue.

     13. ADJUSTMENTS. In the event of any change in the outstanding Common Stock
of the Company by reason of a stock split, stock dividend, combination or
reclassification of shares, recapitalization, merger, or similar event, the
Committee may adjust proportionally (a) the number of shares of Common Stock (i)
reserved under the Plan, (ii) for which Awards may be granted to an individual
Participant, and (iii) covered by outstanding Awards; (b) the stock prices

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related to outstanding Awards; and (c) the appropriate Fair Market Value and
other price determinations for such Awards. In the event of any other change
affecting the Common Stock or any distribution (other than normal cash
dividends) to holders of Common Stock, such adjustments as may be deemed
equitable by the Committee, including adjustments to avoid fractional shares,
shall be made to give proper effect to such event. In the event of a corporate
merger, consolidation, acquisition of property or stock, separation,
reorganization or liquidation, the Committee shall be authorized to issue or
assume Stock Options, whether or not in a transaction to which Section 424(a) of
the Code applies, by means of substitution of new Stock Options for previously
issued Stock Options or an assumption of previously issued Stock Options.

     14. NOTICE. Any notice to the Company required by any of the provisions of
the Plan shall be addressed to the director of finance of the Company in
writing, and shall become effective when it is received by his office.

     15. GOVERNING LAW. The Plan and all determinations made and actions taken
pursuant hereto shall be governed by the laws of the State of Delaware, without
giving effect to principles of conflicts of laws, and construed accordingly.

     16. EFFECTIVE AND TERMINATION DATES. The effective date of the Plan is June
9, 2000. The Plan shall terminate on June 8, 2010 subject to earlier termination
by the Board pursuant to Section 10, after which no Awards may be made under the
Plan, but any such termination shall not affect Awards then outstanding or the
authority of the Committee to continue to administer the Plan.

     17. OTHER BENEFIT AND COMPENSATION PROGRAMS. Payments and other benefits
received by a Participant pursuant to an Award shall not be deemed a part of
such Participant's regular, recurring compensation for purposes of the
termination, indemnity or severance pay law of any country and shall not be
included in, nor have any effect on, the determination of benefits under any
other employee benefit plan, contract or similar arrangement, unless the
Committee expressly determines otherwise.

     18. DISSOLUTION OR LIQUIDATION OF THE COMPANY. Should dissolution or
liquidation of the Company be envisaged, the Committee shall be entitled, at its
sole discretion, to authorize all Participants to exercise their Awards within a
period which it shall determine, exempting them from the provisions of their
Award Agreements pertaining to the exercise period of the Awards. All Awards not
exercised during such period shall lapse upon the expiration of such period. In
the absence of such authorization, any unvested Awards shall lapse upon the
occurrence of the dissolution or liquidation.

     19. MERGER, SPLIT-UP OR TRANSFER OF ASSETS OF THE COMPANY. In the event of
a merger or a split-up of the Company, or the sale of substantially all the
assets of the Company, the acquiring or transferee company, or one of its
affiliates, shall replace the Company as regards its obligations vis a vis the
Participants. In relation thereto, depending on the circumstances, it may be
provided that:

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            (a) either the Awards will be exercisable for shares of the
     acquiring or transferee company, in which case the number and price of
     shares governed by the Awards shall be calculated on the basis of the
     exchange ratio applicable to the transaction.

            (b) or that each Award will be replaced by the acquiring or
     transferee company with an equivalent right. A right shall be deemed to be
     equivalent if it entitles its holder to the same compensation, regardless
     of the form thereof (shares, cash or otherwise), as that received by
     holders of Common Stock, it being specified that once the shareholders of
     the Company have been offered a choice of more than one form of
     compensation, the compensation to which the Participants shall be entitled
     shall be that which as been chosen by the holders of the majority of
     existing shares of Common Stock of the Company.

     However, as an alternative to the above-mentioned substitution of the
acquiring or transferee company for the Company, the Committee shall be entitled
to accelerate the vesting of all unvested Awards. In this case, the Committee
shall inform the Participants in writing that all of their Awards may be
exercised within a period of fifteen (15) days from the date of said notice and
that Awards not exercised within said period shall lapse.

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                                   APPENDIX A

                  PROVISIONS APPLICABLE TO CALIFORNIA RESIDENTS

Notwithstanding anything in the Plan or any Award Agreement to the contrary, the
following provisions shall apply to any Award granted under the Plan to a
resident of the State of California made prior to a public offering of capital
stock of the Company that is effected pursuant to a registration statement filed
with, and declared effective by, the Securities and Exchange Commission under
the Securities Act of 1933, as amended, and only to the extent required by
applicable law and, in the event of any conflict or inconsistency between the
following provisions and the provisions otherwise appearing in the Plan, the
following provisions shall control, solely with respect to Stock Options or
other awards granted under the Plan to residents of the State of California:

1.   At no time shall the total number of shares of Company stock issuable upon
     exercise of all outstanding Stock Options granted pursuant to this Plan and
     the total number of shares provided for under any bonus or similar plan or
     agreement of the Company exceed the limitations set forth in Rule
     260.140.45 promulgated under the California Code, based on the number of
     shares of the Company which are outstanding at the time the calculation is
     made.

2.   The exercise price of a Stock Option granted to a California resident may
     not be less than 85% of the "fair value" (as defined by Rule 260.140.50
     promulgated under the California Code) of the Company's Common Stock at the
     time the Stock Option is granted (or 110% of the "fair value" in the case
     of any person who owns stock possessing more than 10% of the total combined
     voting power of all classes of stock of the Company or its parent or
     subsidiary corporations at the time of such grant).

3.   The exercise period of a Stock Option granted to a California resident
     shall be no longer than 120 months from the date the Stock Option is
     granted.

4.   The number of securities purchasable and the exercise price thereof under
     the Stock Options will be adjusted proportionately in the event of a stock
     split, reverse stock split, stock dividend, recapitalization, combination,
     reclassification or other distribution of the Company's equity securities
     without receipt of consideration by the Company, of or on the Company's
     class or series of securities underlying the Stock Option.

5.   A Stock Option granted to a California resident shall not be transferable,
     other than by will or the laws of descent and distribution, or as permitted
     by Rule 701 of the Securities Act of 1933, as amended.

6.   A Stock Option granted to a California resident shall become exercisable at
     the rate of at least 20% per year over 5 years from the date the Stock
     Option is granted, subject to reasonable conditions such as continued
     employment. However, in the case of a Stock Option granted to a California
     resident who is an officer, director, or consultant of the

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     Company or any of its affiliates, the Stock Option may become fully
     exercisable, subject to reasonable conditions such as continued employment,
     at any time or during any period established by the Company.

7.   Unless employment is terminated for cause as defined by applicable law, the
     terms of the Plan or Award Agreement or a contract of employment, the right
     to exercise a Stock Option granted to a California resident in the event of
     termination of such Participant's employment (to the extent that such
     Participant is otherwise entitled to exercise on the date of termination of
     employment) shall terminate as follows:

        (a) At least 6 months from the date of termination if termination was
        caused by death or disability; or

        (b) At least 30 days from the date of termination if termination was
        caused by an event other than death or disability.

8.   The Plan shall terminate on the earlier of ten years after the date the
     Plan is adopted or the date the Plan is approved by the shareholders of the
     Company

9.   The Plan shall be available to California residents only if the
     shareholders of the Company approve the Plan within 12 months before or
     after the date the Plan is adopted. Any Stock Option exercised by a
     California resident before such stockholder approval is obtained shall be
     rescinded if such stockholder approval is not subsequently obtained and
     such shares shall not be counted in determining whether the required
     stockholder approval is obtained.

10.  Each California resident participating in the Plan will be provided with a
     copy of the Company's annual financial statements (which need not be
     audited) in accordance with Section 260.140.46 of Title 10 of the
     California Code of Regulations. The Company shall not be required to
     provide such statements to key employees whose duties with the Company
     assure access to equivalent information.

11.  The Company will comply with Section 260.140.1 of Title 10 of the
     California Code of Regulations with respect to the voting rights of Common
     Stock and similar equity securities.

12.  At the discretion of the Committee, the Company may reserve to itself
     and/or its assignee(s) in the Award Agreement a right to repurchase
     securities held by an Award recipient upon such Award recipient's
     termination of employment at any time within 90 days after such Award
     recipient's termination date (or in the case of securities issued upon
     exercise of a Stock Option after the termination date, within 90 days after
     the date of such exercise) for cash or cancellation of purchase money
     indebtedness, at:

        (a) no less than the Fair Market Value of such securities as of the date
        of the Award recipient's termination of employment, PROVIDED, that such
        right to repurchase securities terminates when the Company's securities
        have become publicly traded; or

        (b) the Award recipient's original purchase price, PROVIDED, that such
        right to repurchase securities at the original purchase price lapses at
        the rate of at least 20% of the securities

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        per year over 5 years from the date the Stock Option is granted (without
        respect to the date the Stock Option was exercised or became
        exercisable).

        The securities held by an officer, director, manager or consultant of
        the Company or an affiliate may be subject to additional or greater
        restrictions.

13.  The Plan is intended to comply with Section 25102(o) of the California
     Corporations Code. Any provision of this Plan which is inconsistent with
     Section 25102(o), including without limitation any provision of this Plan
     that is more restrictive than would be permitted by Section 25102(o) as
     amended from time to time, shall, without further act or amendment by the
     Board, be reformed to comply with the provisions of Section 25102(o). If at
     any time the Committee determines that the delivery of Common Stock under
     the Plan is or may be unlawful under the laws of any applicable
     jurisdiction, or federal or state securities laws, the right to exercise a
     Stock Option or receive shares of Common Stock pursuant to a Stock Option
     shall be suspended until the Committee determines that such delivery is
     lawful. The Company shall have no obligation to effect any registration or
     qualification of the Common Stock under federal or state laws.

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                                  AMENDMENT TO

                             2000 STOCK OPTION PLAN

                                       OF

                                   PICIS, INC.

A. The Picis, Inc. 2000 Stock Option Plan is hereby amended as follows:

     1. Section 2(j) is hereby amended by deleting said section in its entirety
and substituting the following in lieu thereof:

          "(j) 'Fair Market Value' shall mean, as of any date, the value of
          Common Stock determined as follows:

               (i)   If the Common Stock is listed on any established stock
                     exchange or national market system, Fair Market Value shall
                     be the closing sales price for such stock as quoted on such
                     exchange or system for such date, as reported in The Wall
                     Street Journal or such other source as the Committee deems
                     reliable. If there are no market quotations for the Common
                     Stock for such date, the determination shall be made by
                     reference to the last date preceding such date for which
                     there are market quotations.

               (ii)  If the Common Stock is regularly quoted by a recognized
                     securities dealer but selling prices are not reported, Fair
                     Market Value shall be the mean between the high bid and low
                     asked prices for the Common Stock on such date. If there
                     are no bids or asked prices for the Common Stock such date,
                     the determination shall be made by reference to the last
                     date preceding such date for which there are bid and asked
                     prices.

               (iii) In the absence of an established market for the Common
                     Stock, the Fair Market Value thereof shall be determined in
                     good faith by the Committee, with the Committee's
                     determination being binding on the Company and the
                     Participants for all purposes."

     2. Section 8 is hereby amended by deleting said Section in its entirety and
substituting the following in lieu thereof:

          "8 Stock Option Exercise. The price at which shares of Common Stock
          may be purchased under a Stock Option shall be paid in full at the
          time of exercise in case or by any other means permitted by the
          Committee, including by means of tendering shares of Common Stock
          owned by the Participant outright, either directly or by attestation,
          valued at Fair Market Value on the date of exercise, or any
          combination thereof."

<Page>

     3. Section 9 is hereby amended by adding the following at the end thereof:

          "Any withholding in the form of Common Stock shall not exceed the
          minimum required tax withholding amount."

     4. Section 13 is hereby amended by deleting the first two sentences thereof
and substituting the following in lieu thereof:

          "In the event of any change in the outstanding Common Stock of the
          Company by reason of stock split, stock dividend, combination of
          reclassification of shares, recapitalization, merger or similar event,
          or in the event of any distribution of cash or other property to the
          shareholders (other than a regular cash dividend), the Committee shall
          adjust in an equitable and proportionate manner (a) the total number
          of shares of Common Stock (i) reserved under the Plan, (ii) for which
          Awards may be granted to an individual Participant, and (iii) covered
          by outstanding Awards; (b) the stock prices related to outstanding
          Awards; and (c) the appropriate Fair Market Value and other price
          determination for such Awards. No fractional shares of Common Stock
          shall be issued under the Plan resulting from any such adjustment, but
          the Committee in its discretion may make a cash payment in lieu of
          fractional shares."

B. The effective date of this amendment shall be October 16, 2006.

C. Except as amended herein, the Picis, Inc. 2000 Stock Option Plan is hereby
confirmed in all other respects.

<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART I

                         NOTICE OF GRANT OF STOCK OPTION

     We are pleased to inform you that you have been granted a Stock Option to
purchase shares of Common Stock of PICIS, Inc., subject to the terms and
conditions of the PICIS, Inc. 2000 Stock Option Plan (the "Plan") and of this
Award Agreement. Unless otherwise defined herein, all terms used in this Award
Agreement shall have the same meanings as set forth in the Plan.

     Award Number:

     Date of Award:

     Exercise price per share:

     Total number of shares:

     Total exercise price:

     1. INCENTIVE STOCK OPTIONS. It is intended that all or a portion of the
Stock Option that vests in any calendar year shall qualify as an incentive stock
option pursuant to Section 422 of the Code to the extent it meets the
requirements thereof, including the $100,000 per year limitation contained in
Code Section 422(d).

     2. VESTING SCHEDULE. The Stock Option granted pursuant to this Award will
vest according to the following schedule, PROVIDED, HOWEVER, that you must be
employed by the Company on each vesting date for that portion of the Stock
Option to vest:

<Table>
<Caption>
  Number of Shares of Common Stock                  Vesting Date
--------------------------------------------------------------------------------
<S>                                                 <C>

</Table>

<Page>

     3. ACCELERATED VESTING. If a Change in Control occurs while you are
employed by the Company and either (a) the company acquiring the assets or stock
of the Company does NOT assume the Company's obligations under this Award
Agreement in their totality (other than adjustments to the number of shares and
the exercise price which still maintain the economics of the Stock Option) as
provided in Section 19 of the Plan or (b) your employment is terminated by the
acquiring or transferee company after the Change in Control, any unvested
options will become immediately vested and exercisable upon the first to occur
of subparagraphs (a) or (b).

     4. EXPIRATION DATE. In all events, and notwithstanding anything herein
contained to the contrary, this Stock Option shall expire no later than DATE.

     By your signature and the signature of the Company's representative below,
you and the Company agree that the Stock Option which has been awarded to you
under this Award Agreement is subject to the terms and conditions of the Plan
which is attached hereto as Exhibit A. As provided in the Plan, you hereby agree
to accept as binding any decision of the Committee with respect to the
interpretation of the Plan and this Award Agreement, or any other matters
associated therewith. You further agree to notify the Company as soon as
possible upon any change in your residential address. By your signature below,
you certify that you do not hold more than 10% of the voting rights of any type
of securities issued by the Company, and that consequently the Stock Option
awarded pursuant to the Award Agreement may be considered an incentive stock
option, if all of the requirements of Code Section 422 are met.

     By your signature below, you acknowledge the confidential nature of the
grant made to you hereby, and you agree not to disclose to any person (other
than those members of the company's management charged with the administration
of the Plan and to your independent legal, tax and financial advisors provided
they abide by this paragraph) the number of shares subject to this Award and the
vesting schedule pursuant to which such shares may be purchased. You further
agree that any disclosure made by you in violation of this paragraph may, at the
Company's option, result in your forfeiture of this Award.

<Page>

     IN WITNESS WHEREOF, the Company has caused these presents to be executed as
of DATE.

                                        PICIS, INC.

                                        By:
                                            ------------------------------------
                                            Todd Cozzens
                                            INSERT AUTO SIG

     The undersigned Participant hereby accepts the foregoing Stock Option and
agrees to the several terms and conditions of this Award Agreement and of the
Plan.

                                        ----------------------------------------
                                        [typed name]

<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART II

                     TERMS AND CONDITIONS OF AWARD AGREEMENT

                                    ARTICLE I
                              AWARD OF STOCK OPTION

     1.1. GRANT OF STOCK OPTION. The Company hereby grants to the Participant
named in the Notice of Grant attached hereto as Part I of this Award Agreement a
Stock Option giving the right to purchase all or any part of the aggregate
number of shares of Common Stock as set forth in the Notice of Grant, at the
exercise price per share set forth in the Notice of Grant, subject to the terms
and conditions of the PICIS, Inc. 2000 Stock Option Plan.

     1.2 TIME LIMITATIONS ON EXERCISE OF STOCK OPTION. Except as otherwise
provided in the Plan, and subject to Section 1.3., below, the Stock Option
granted pursuant to this Award Agreement is exercisable, in whole or in part,
from the vesting date to the expiration date as set forth in the Notice of
Grant. In all events, the Stock Option will become fully vested and immediately
exercisable if the Participant is employed by the Company or its affiliates, or
if the Participant is currently serving as a director on the Board, upon a
Change in Control.

     1.3 TERMINATION OF EMPLOYMENT. The Stock Option shall be exercisable upon
the termination of the Participant's employment relationship with the Company
and its affiliates or upon the Participant's ceasing to serve as a director on
the Board only in the manner and to the extent provided in Section 11 of the
Plan, as modified herein. This Stock Option, to the extent vested on termination
of employment or service as a director, shall remain exercisable for a period of
six (6) months after the Participant's death or Disability as defined in Section
11(b) of the Plan. In all other cases, the Stock Option, to the extent vested on
termination of employment or service as a director, shall be exercisable for
ninety (90) days following the termination of the Participant's employment or
service for any reason other than Cause. If a Participant's employment or
service is terminated for Cause, the Stock Option shall expire immediately. Any
unvested portion of this Stock Option shall expire immediately upon
Participant's termination of employment for any reason. In all events, and
notwithstanding anything herein contained to the contrary, this Stock Option
shall expire no later than the expiration date as indicated in the Notice of
Grant.

     1.4. METHOD OF EXERCISING STOCK OPTION. The Stock Option may be exercised
in whole or in part by delivery to the Company, at its offices in Wakefield, MA,
of (a) a written notice in the form attached hereto as EXHIBIT B identifying the
Stock Option and stating the number of shares with respect to which it is being
exercised, and (b) payment in full of the exercise price of the shares then
being acquired in the form permitted by Section 1.5 of this Award Agreement. The
written notice shall be signed by the Participant and shall be delivered to the
Company in

<Page>

person, by certified mail with return receipt requested, or by facsimile to be
immediately confirmed by certified mail with return receipt requested. The
Company shall have the right to delay the issue or delivery of any shares to be
delivered hereunder until (a) the completion of such registration or
qualification of such shares under federal, state or foreign law, ruling or
regulation as the Company shall deem to be necessary or advisable, (b) receipt
from the Participant of such documents and information as the Company may deem
necessary or appropriate in connection with such registration or qualification
or the issuance of shares hereunder, and (c) arrangements satisfactory to the
Company have been made with regard to any tax withholding obligations the
Company believes is required as a result of the exercise of the Stock Option.

     1.5. METHODS OF PAYMENT. Payment of the exercise price for the shares of
Common Stock which are being purchased pursuant to the exercise of the Stock
Option shall be made using any of the following means of payment, at the
election of the Participant:

            (1) wire transfer;

            (2) check;

            (3) a tender of shares of Common Stock, either directly or by
     attestation, which have been held by the Participant for more than six
     months and have not been used within the prior six-month period to exercise
     a Stock Option, valued at Fair Market Value on the date of exercise; or

            (4) any combination of the foregoing means of payment.

     1.6. PROHIBITIONS AGAINST TRANSFER. The Stock Option, and the rights and
privileges conferred hereby, may not be transferred, assigned, pledged or
hypothecated in any way (whether by operation of law or otherwise) by the
Participant, or be subject to execution, attachment or similar process, and
shall be exercisable only by the Participant, except as provided in Section
11(b) of the Plan.

     1.7. PARTICIPANT'S REPRESENTATIONS. In the event the shares have not been
registered under the Securities Act of 1933, as amended (the "Securities Act"),
at the time this Stock Option is exercised, the Participant shall, if required
by the Company, concurrently with the exercise of all or any portion of this
Stock Option, deliver to the Company his or her Investment Representation
Statement in form attached hereto as EXHIBIT B.

     1.8. LOCK-UP PERIOD. If so requested by the Company or any representative
of the underwriters (the "Managing Underwriter") in connection with any
registration of the offering of any securities of the Company under the
Securities Act, the Participant shall not sell or otherwise transfer any shares
or other securities of the Company during the 180-day period (or such other
period as may be requested in writing by the Managing Underwriter and agreed to
in writing by the Company) (the "Market Standoff Period") following the
effective date of a registration statement of the Company filed under the
Securities Act. Such restriction shall apply only to the first registration
statement of the Company to become effective under the Securities Act that

                                        2
<Page>

includes securities to be sold on behalf of the Company to the public in an
underwritten public offering under the Securities Act. The Company may impose
stop-transfer instructions with respect to securities subject to the foregoing
restrictions until the end of such Market Standoff Period.

                                   ARTICLE II
                                  MISCELLANEOUS

     2.1. PROVISIONS OF THE PLAN CONTROL. This Award Agreement shall be governed
by the provisions of the Plan, the terms and conditions of which are
incorporated herein by reference. In the event that the provisions of this Award
Agreement and the Plan conflict, the Plan shall control. The Plan empowers the
Committee to make interpretations, rules and regulations thereunder, and, in
general, provides that determinations of such Committee with respect to the Plan
shall be binding upon the Participant.

     2.2. TAXES. The Company may require payment or reimbursement of or may
withhold any tax that it believes is required as a result of the exercise of the
Stock Option, and the Company may defer making delivery with respect to shares
for which the Stock Option was exercised until arrangements satisfactory to the
Company have been made with respect to such withholding obligations.

     2.3. NOTICES. Any notice to be given to the Company under the terms of this
Award Agreement shall be given in writing to the Company in care of its
Secretary at 100 Quannapowitt Parkway, Suite 405, Wakefield MA 01880. Any notice
to be given to the Participant may be addressed to him at his address as it
appears on the payroll or other records of the Company or any affiliate thereof.
Any such notice shall be deemed to have been duly given if and when actually
received by the party to whom it is addressed, as evidenced by a written receipt
to that effect.

     2.4. GOVERNING LAW. This Award Agreement and all questions arising
hereunder or in connection herewith shall be determined in accordance with the
laws of the State of Delaware, without giving effect to the principles of
conflicts of laws.

                                        3

<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART I

                         NOTICE OF GRANT OF STOCK OPTION

     We are pleased to inform you that you have been granted a Stock Option to
purchase shares of Common Stock of PICIS, Inc., subject to the terms and
conditions of the PICIS, Inc. 2000 Stock Option Plan (the "Plan") and of this
Award Agreement. Unless otherwise defined herein, all terms used in this Award
Agreement shall have the same meanings as set forth in the Plan.

     Award Number:

     Date of Award:

     Exercise price per share:

     Total number of shares:

     Total exercise price:

     1. NONQUALIFIED STOCK OPTION. The Stock Option granted pursuant to this
Award is intended to be a nonqualified stock option and therefore, shall not
qualify as an incentive stock option pursuant to Section 422 of the Code.

     2. VESTING SCHEDULE. The Stock Option granted pursuant to this Award is
immediately vested.

     3. EXPIRATION DATE. In all events, and notwithstanding anything herein
contained to the contrary, this Stock Option shall expire no later than DATE
[FIVE YEARS FROM DATE OF AWARD]

     By your signature and the signature of the Company's representative below,
you and the Company agree that the Stock Option which has been awarded to you
under this Award Agreement is subject to the terms and conditions of the Plan
which is attached hereto as Exhibit A. As provided in the Plan, you hereby agree
to accept as binding any decision of the Committee with respect to the
interpretation of the Plan and this Award Agreement, or any other matters
associated therewith. You further agree to notify the Company as soon as
possible upon any change in your residential address.

<Page>

     IN WITNESS WHEREOF, the Company has caused these presents to be executed as
of DATE.

                                        PICIS, INC.

                                        By:
                                            ----------------------------------
                                            Todd Cozzens
                                            INSERT AUTO SIG

     The undersigned Participant hereby accepts the foregoing Stock Option and
agrees to the several terms and conditions of this Award Agreement and of the
Plan.

                                        ---------------------------------------
                                        [typed name]

<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART II

                     TERMS AND CONDITIONS OF AWARD AGREEMENT

                                    ARTICLE I
                              AWARD OF STOCK OPTION

     1.1. GRANT OF STOCK OPTION. The Company hereby grants to the Participant
named in the Notice of Grant attached hereto as Part I of this Award Agreement a
Stock Option giving the right to purchase all or any part of the aggregate
number of shares of Common Stock as set forth in the Notice of Grant, at the
exercise price per share set forth in the Notice of Grant, subject to the terms
and conditions of the PICIS, Inc. 2000 Stock Option Plan.

     1.2 TIME LIMITATIONS ON EXERCISE OF STOCK OPTION. Except as otherwise
provided in the Plan, the Stock Option granted pursuant to this Award Agreement
is exercisable, in whole or in part, from the vesting date to the expiration
date as set forth in the Notice of Grant.

     1.3. METHOD OF EXERCISING STOCK OPTION. The Stock Option may be exercised
in whole or in part by delivery to the Company, at its offices in Wakefield, MA,
of (a) a written notice in the form attached hereto as EXHIBIT B identifying the
Stock Option and stating the number of shares with respect to which it is being
exercised, and (b) payment in full of the exercise price of the shares then
being acquired in the form permitted by Section 1.4 of this Award Agreement. The
written notice shall be signed by the Participant and shall be delivered to the
Company in person, by certified mail with return receipt requested, or by
facsimile to be immediately confirmed by certified mail with return receipt
requested. The Company shall have the right to delay the issue or delivery of
any shares to be delivered hereunder until (a) the completion of such
registration or qualification of such shares under federal, state or foreign
law, ruling or regulation as the Company shall deem to be necessary or
advisable, (b) receipt from the Participant of such documents and information as
the Company may deem necessary or appropriate in connection with such
registration or qualification or the issuance of shares hereunder, and (c)
arrangements satisfactory to the Company have been made with regard to any tax
withholding obligations the Company believes is required as a result of the
exercise of the Stock Option.

     1.4. METHODS OF PAYMENT. Payment of the exercise price for the shares of
Common Stock which are being purchased pursuant to the exercise of the Stock
Option shall be made using any of the following means of payment, at the
election of the Participant:

            (1) wire transfer;

            (2) check;

<Page>

            (3) a tender of shares of Common Stock, either directly or by
     attestation, which have been held by the Participant for more than six
     months and have not been used within the prior six-month period to exercise
     a Stock Option, valued at Fair Market Value on the date of exercise; or

            (4) any combination of the foregoing means of payment.

     1.5. PROHIBITIONS AGAINST TRANSFER. The Stock Option, and the rights and
privileges conferred hereby, may not be transferred, assigned, pledged or
hypothecated in any way (whether by operation of law or otherwise) by the
Participant, or be subject to execution, attachment or similar process, and
shall be exercisable only by the Participant, except as provided in Section
11(b) of the Plan.

     1.6. PARTICIPANT'S REPRESENTATIONS. In the event the shares have not been
registered under the Securities Act of 1933, as amended (the "Securities Act"),
at the time this Stock Option is exercised, the Participant shall, if required
by the Company, concurrently with the exercise of all or any portion of this
Stock Option, deliver to the Company his or her Investment Representation
Statement in form attached hereto as EXHIBIT C.

     1.7. LOCK-UP PERIOD. If so requested by the Company or any representative
of the underwriters (the "Managing Underwriter") in connection with any
registration of the offering of any securities of the Company under the
Securities Act, the Participant shall not sell or otherwise transfer any shares
or other securities of the Company during the 180-day period (or such other
period as may be requested in writing by the Managing Underwriter and agreed to
in writing by the Company) (the "Market Standoff Period") following the
effective date of a registration statement of the Company filed under the
Securities Act. Such restriction shall apply only to the first registration
statement of the Company to become effective under the Securities Act that
includes securities to be sold on behalf of the Company to the public in an
underwritten public offering under the Securities Act. The Company may impose
stop-transfer instructions with respect to securities subject to the foregoing
restrictions until the end of such Market Standoff Period.

                                   ARTICLE II
                                  MISCELLANEOUS

     2.1. PROVISIONS OF THE PLAN CONTROL. This Award Agreement shall be governed
by the provisions of the Plan, the terms and conditions of which are
incorporated herein by reference. In the event that the provisions of this Award
Agreement and the Plan conflict, the Plan shall control. The Plan empowers the
Committee to make interpretations, rules and regulations thereunder, and, in
general, provides that determinations of such Committee with respect to the Plan
shall be binding upon the Participant.

     2.2. TAXES. The Company may require payment or reimbursement of or may
withhold any tax that it believes is required as a result of the exercise of the
Stock Option, and the Company may defer making delivery with respect to shares
for which the Stock Option was

                                        2
<Page>

exercised until arrangements satisfactory to the Company have been made with
respect to such withholding obligations.

     2.3. NOTICES. Any notice to be given to the Company under the terms of this
Award Agreement shall be given in writing to the Company in care of its
Secretary at 100 Quannapowitt Parkway, Suite 405, Wakefield MA 01880. Any notice
to be given to the Participant may be addressed to him at his address as it
appears on the records of the Company or any affiliate thereof. Any such notice
shall be deemed to have been duly given if and when actually received by the
party to whom it is addressed, as evidenced by a written receipt to that effect.

     2.4. GOVERNING LAW. This Award Agreement and all questions arising
hereunder or in connection herewith shall be determined in accordance with the
laws of the State of Delaware, without giving effect to the principles of
conflicts of laws.

                                        3<Page>

                                                                    Exhibit 10.7

                           2005 EQUITY INCENTIVE PLAN

                                       OF

                                   PICIS, INC.

                   AS AMENDED AND RESTATED ON OCTOBER 16, 2006

1. PURPOSE

     The purpose of the Plan is to provide for compensation alternatives for
certain Employees and Directors using or based on the common stock of the
Company. These alternatives are intended to be used as a means to attract and
retain superior Employees and Directors, to provide a stronger incentive for
such Employees and Directors to put forth maximum effort for the continued
success and growth of the Company and its Subsidiaries, and in combination with
these goals, to provide Employees and Directors with a proprietary interest in
the performance and growth of the Company.

2. DEFINITIONS

     Unless the context otherwise requires, the following terms shall have the
meanings set forth below:

     (a)  "Administrator" shall mean the compensation committee of the Board of
          Directors with respect to grants to Employees under the Plan and the
          Board of Directors with respect to grants to Directors under the Plan.
          If there is no compensation committee, the Administrator in all
          instances shall be the Board of Directors.

     (b)  "Award" shall mean an Option, Restricted Stock, an SAR, Deferred Stock
          or Performance Shares granted under the Plan.

     (c)  "Board of Directors" shall mean the board of directors of PICIS, Inc.

     (d)  "Cause" shall mean, with respect to any Participant, one of the
          following:

               (i) Cause shall have the meaning assigned to such term in an
          employment agreement in effect between the Company and a Participant;
          or

               (ii) If 2(d)(i), above, is not applicable, Cause shall have the
          meaning assigned to that term under any statute which governs a
          Participant's employment with the Company; or

               (iii) If neither 2(d)(i) nor 2(d)(ii), above, are applicable,
          Cause shall mean termination of a Participant's employment with the
          Company or service as a director for (A) any failure of the
          Participant to substantially perform his or her

<Page>

          duties with the Company (other than by reason of illness) which occurs
          after the Company has delivered to the Participant a demand for
          performance which specifically identifies the manner in which the
          Company believes the Participant has failed to perform his or her
          duties, and the Participant fails to resume performance of his or her
          duties on a continuous basis within 14 days after receiving such
          demand, (B) the commission by the Participant of any act of dishonesty
          or disloyalty involving the Company or its business, or (C) the
          conviction of the Participant of a felony or misdemeanor which, in the
          reasonable judgment of the Committee, is substantially related to the
          Participant's position with the Company or substantially impairs the
          Participant's ability to perform his or her duties with the Company.

     (e)  "Change in Control" shall mean any of the following events:

               (i) the acquisition by an individual, entity or group (within the
          meaning of Section 13(d)(2) of the Exchange Act), (a "Person"), after
          the date hereof, of beneficial ownership (within the meaning of Rule
          13d-3 promulgated under the Exchange Act) of 35% or more of either (A)
          the then outstanding shares of common stock of the Company (the
          "Outstanding Company Common Stock") plus the then outstanding shares
          of preferred stock of the Company, on an as converted basis or (B) the
          combined voting power of the then outstanding voting securities of the
          Company entitled to vote generally in the election of directors (the
          "Outstanding Company Voting Securities"); provided, however, that for
          purposes of this subsection (i), the following acquisitions shall not
          constitute a Change of Control: (A) any acquisition directly from the
          Company, (B) any acquisition by the Company, (C) any acquisition by
          any employee benefit plan (or related trust) sponsored or maintained
          by the Company, or (D) any acquisition by any corporation pursuant to
          a transaction which complies with clauses (A), (B) and (C) of
          subsection (iii) of this Section 2(e); and provided, further, that for
          purposes of this subsection and subsection (iii), below, none of the
          stockholders of the Company, and/or any person who becomes a
          stockholder of the Company in a private placement conducted by the
          Company shall be aggregated and treated as members of a group
          constituting a single "Person"; or

               (ii) individuals who, as of the date hereof, constitute the Board
          (the "Incumbent Board") cease for any reason to constitute at least a
          majority of the Board; provided, however, that any individual becoming
          a director subsequent to the date hereof whose election, or nomination
          for election by the Company's shareholders, was approved by a vote of
          at least a majority of the directors then constituting the Incumbent
          Board shall be considered as though such individual were a member of
          the Incumbent Board, but excluding, for this purpose, any such
          individual whose initial assumption of office occurs as a result of an
          actual or threatened election contest with respect to the election or
          removal of directors or other actual or threatened solicitation of
          proxies or consents by or on behalf of a person other than the Board;
          or

                                       2

<Page>

               (iii) consummation of a reorganization, merger or consolidation
          or sale or other disposition of all or substantially all of the assets
          of the Company for which approval of the shareholders of the Company
          is required (a "Business Combination"), in each case, unless,
          immediately following such Business Combination, (A) all or
          substantially all of the individuals and entities who were the
          beneficial owners, respectively, of the Outstanding Company Common
          Stock and Outstanding Company Voting Securities immediately prior to
          such Business Combination beneficially own, directly or indirectly,
          more than 60% of, respectively, the then outstanding shares of common
          stock and the combined voting power of the then outstanding voting
          securities entitled to vote generally in the election of directors, as
          the case may be, of the corporation resulting from such Business
          Combination (including, without limitation, a corporation which as a
          result of such transaction owns the Company or all or substantially
          all of the Company's assets either directly or through one or more
          subsidiaries) in substantially the same proportions as their
          ownership, immediately prior to such Business Combination of the
          Outstanding Company Common Stock and Outstanding Company Voting
          Securities, as the case may be, (B) no Person (excluding any employee
          benefit plan (or related trust) of the Company or such corporation
          resulting from such Business Combination) beneficially owns, directly
          or indirectly, 35% or more of, respectively, the then outstanding
          common stock of the corporation resulting from such Business
          Combination or the combined voting power of the then outstanding
          voting securities of such corporation except to the extent that such
          ownership existed prior to the Business Combination and (C) at least a
          majority of the members of the Board of Directors of the corporation
          resulting from such Business Combination were members of the Incumbent
          Board at the time of the execution of the initial agreement, or of the
          action of the Board, providing for such Business Combination; or

               (iv) approval by the shareholders of the Company of a complete
          liquidation or dissolution of the Company.

          Notwithstanding the foregoing, (a) in no event will an initial public
          offering of the stock of the Company constitute a Change in Control
          and (b) subparagraph (iv) will only be included as a Change of Control
          to the extent it would not cause payments hereunder to be subject to
          penalty under Section 409A of the Code.

          Following the occurrence of an event which is not a Change in Control
          whereby there is a successor holding company to the Company, or, if
          there is no such successor, whereby the Company is not the surviving
          corporation in a merger or consolidation, the surviving corporation or
          successor holding company (as the case may be), for purposes of this
          definition, shall thereafter be referred to as the Company.

     (f)  "Code" shall mean the Internal Revenue Code of 1986, as amended.

                                       3

<Page>

     (g)  "Company" shall mean PICIS, Inc., a Delaware corporation.

     (h)  "Deferred Stock" shall mean a right to receive one or more Shares from
          the Company in accordance with, and subject to, Paragraph 11 of the
          Plan.

     (i)  "Deferred Stock Agreement" shall mean the agreement between the
          Company and a Participant whereby Deferred Stock is granted to such
          Participant.

     (j)  "Director" shall mean an individual who is a non-Employee member of
          the Board of Directors.

     (k)  A Participant shall be considered to be suffering from a "Disability"
          if the Participant is, by reason of any medically determinable
          physical or mental impairment which can be expected to result in death
          or can be expected to last for a continuous period of not less than 12
          months, receiving income replacement benefits for a period of not less
          than three months under an accident and health plan covering Employees
          of the Participant's employer.

     (l)  "Employee" shall mean any individual performing services for the
          Company or a Subsidiary and designated as an employee of the Company
          or its Subsidiaries on the payroll records thereof. An Employee shall
          not include any individual during any period he or she is classified
          or treated by the Company or a Subsidiary as an independent
          contractor, a consultant, or an employee of an employment, consulting
          or a temporary agency or any other entity other than the Company or a
          Subsidiary, without regard to whether such individual is subsequently
          determined to have been, or is subsequently retroactively reclassified
          as a common-law employee of the Company or a Subsidiary during such
          period.

     (m)  "Exchange Act" shall mean the Securities Exchange Act of 1934, as
          amended.

     (n)  "Fair Market Value" shall mean, as of any date, the value of the
          Shares determined as follows:

               (i) If the Shares are listed on any established stock exchange or
          national market system, Fair Market Value shall be the closing sales
          price for such stock (or the closing bid, if no sales were reported)
          as quoted on such exchange or system for such date, as reported in THE
          WALL STREET JOURNAL or such other source as the Administrator deems
          reliable. If there are no market quotations for the Shares on such
          date, the determination shall be made by reference to the last date
          preceding such date for which there are market quotations.

               (ii) Notwithstanding subsection (i) hereof, on the date that the
          initial public offering of the Shares occurs, Fair Market Value means
          the price at which

                                       4

<Page>

          stock is sold in the initial public offering, not the closing price
          (or closing bid, if no sales were reported) on the date of the initial
          public offering.

               (iii) If the Shares are regularly quoted by a recognized
          securities dealer but selling prices are not reported, Fair Market
          Value shall be the mean between the high bid and low asked prices for
          the Shares such date. If there are no bid or asked prices for the
          Shares on such date, the determination shall be made by reference to
          the last date preceding such date for which there are bid and asked
          prices.

               (iv) In the absence of an established market for the Shares, the
          Fair Market Value thereof shall be determined in good faith by the
          Administrator, with the Administrator's determination being binding on
          the Company and the Participants for all purposes.

     (o)  "Grant Value" of an SAR means the Fair Market Value of a Share on the
          date of the grant.

     (p)  "Option" shall mean an option to purchase Shares.

     (q)  "Option Agreement" shall mean the agreement between the Company and a
          Participant whereby an Option is granted to such Participant.

     (r)  "Participant" shall mean an Employee or Director to whom an Award has
          been granted under the Plan.

     (s)  "Performance Shares" shall mean a right to receive Shares from the
          Company upon the attainment of specified performance goals in
          accordance with, and subject to, Paragraph 12 of the Plan.

     (t)  "Performance Shares Agreement" shall mean the agreement between the
          Company and a Participant whereby the Company agrees to grant Shares
          to the Participant upon the attainment of specified performance goals.

     (u)  "Plan" shall mean the 2005 Equity Incentive Plan of the Company.

     (v)  "Restricted Stock" shall mean Shares granted to a Participant by the
          Administrator which are subject to restrictions imposed under
          Paragraph 9 of the Plan.

     (w)  "Restricted Stock Agreement" shall mean the agreement between the
          Company and a Participant whereby Restricted Stock is granted to such
          Participant.

                                       5

<Page>

     (x)  "Retirement" shall mean termination of employment with the Company or
          a Subsidiary or service as a member of the Board on or after the
          attainment of age 65 or such other time as the Administrator shall
          provide.

     (y)  "SAR" shall mean a stock appreciation right with respect to Shares
          granted under the Plan.

     (z)  "SAR Agreement" shall mean the agreement between the Company and a
          Participant whereby an SAR is granted to such Participant.

     (aa) "Share" or "Shares" shall mean the $0.01 par value common stock of the
          Company.

     (bb) "Subsidiary" shall mean any entity in which the Company owns, directly
          or indirectly, more than 50% of the voting interests entitled to vote
          in the election of directors, or any comparable governing body if the
          entity does not have directors.

3. AWARDS AVAILABLE UNDER THE PLAN

     The Administrator may grant Options, Restricted Stock, SARs and Deferred
Stock under the Plan.

4. SHARES RESERVED UNDER PLAN

     (a) Aggregate Limits. The aggregate number of Shares which may be issued
under the Plan pursuant to the exercise, settlement or grant of Awards shall not
exceed the sum of (i) 4,984,903 Shares, (ii) the number of Shares under the
Company's 2000 Stock Option Plan (the "2000 Plan") which are not needed to
fulfill the Company's obligations for awards issued under the 2000 Plan as a
result of forfeiture, expiration, cancellation, termination or net issuances of
awards thereunder, and (iii) as of January 1, 2007 and each January 1
thereafter, a number of Shares equal to the least of (A) three percent (3 %) of
the Company's outstanding Shares on such date, (B) 1,200,000 Shares, or (C) such
lower number of Shares determined by the Board of Directors. Shares issued under
the Plan may be treasury Shares or authorized but unissued Shares, or a
combination of the two, subject to adjustment as provided in Paragraph 16
hereof. For purposes of determining the maximum number of Shares available for
issuance under the Plan, (a) any Shares which are used in settlement of tax
withholding obligations with respect to an Award shall be deemed not to have
been issued, (b) if any Option is exercised by tendering Shares, either actually
or by attestation, to the Company as full or partial payment for such exercise
under this Plan, only the number of Shares issued net of the Shares tendered
shall be deemed issued, (c) any Shares which have been issued as Restricted
Stock which are forfeited to the Company shall be treated, following such
forfeiture, as Shares which have not been issued, and (d) the number of shares
deemed issued upon the exercise of an SAR shall equal (i) the difference between
the Fair Market Value of a Share on the date of exercise less the Grant Value of
the SAR, divided by (ii) the Fair Market Value of a Share, which shall then be
multiplied by the number of SARs exercised.

                                       6

<Page>

     (b) Tax Code Limits. The aggregate number of Shares subject to stock
options or stock appreciation rights granted under this Plan during any calendar
year to any one Participant shall not exceed 2,000,000 Shares. Notwithstanding
anything to the contrary in this Plan, the foregoing limitation shall be subject
to adjustment under Paragraph 16 hereof, but only to the extent that such
adjustment will not affect the status of any Award intended to qualify as
"performance-based compensation" under Section 162(m) of the Code. The aggregate
number of Shares issued pursuant to incentive stock options granted under the
Plan shall not exceed 4,984,903, which limitation shall be subject to adjustment
under Paragraph 16 hereof, only to the extent that such adjustment is consistent
with adjustments permitted of a plan authorizing incentive stock options under
Section 422 of the Code.

5. ADMINISTRATION OF THE PLAN

     The Plan shall be administered by the Administrator, which shall have full
and exclusive power to interpret the Plan, to determine which Directors and
Employees are Participants, to grant waivers of Award restrictions, to determine
the provisions of Award agreements and to adopt such rules, regulations and
guidelines for carrying out the Plan as it may deem necessary or proper. All
determinations of the Administrator under the Plan shall be in its sole
discretion and are binding on the Company and the Participants.

6. DELEGATION OF AUTHORITY

     Except to the extent prohibited by applicable law or the applicable rules
of a stock exchange, the Administrator may delegate to the chief executive
officer and to other senior officers of the Company its duties under the Plan
pursuant to such conditions or limitations as the Administrator may establish.
Any such delegation may be revoked by the Administrator at any time. Consistent
with the foregoing, any delegation of authority may not extend to Awards or
decisions governing persons who are officers of the Company under Section 16 of
the Exchange Act.

7. ELIGIBILITY

     Directors and Employees shall be eligible to receive Options, Restricted
Stock, SARs, Deferred Stock and Performance Shares under the Plan. In
determining the Directors and Employees to whom Awards shall be granted and the
number of Shares to be covered by each Award, the Administrator may take into
account the nature of the services rendered by the respective Employees and
Directors, their present and potential contributions to the success of the
Company, and other such factors as the Administrator in its discretion shall
deem relevant. A Participant may be granted additional Awards under the Plan if
the Administrator shall so determine.

8. OPTIONS: GENERAL PROVISIONS

     Options granted under this Plan shall be subject to such terms and
conditions not inconsistent with the Plan as the Administrator shall determine,
including the following:

                                       7

<Page>

     (a) Option Agreement. Any grant of an Option shall be confirmed by the
execution of an Option Agreement. To the extent this Plan receives the requisite
shareholder approval, Options can be designated as incentive stock options under
Section 422 of the Code in the Option Agreement. If Options are not designated
as incentive stock options, or do not meet the qualifications of Section 422 of
the Code, such Options shall be nonqualified stock options.

     (b) Option Exercise Price. The per share purchase price of the Shares under
each Option granted pursuant to this Plan shall be determined by the
Administrator, but shall not be less than one hundred percent (100%) of the Fair
Market Value per Share on the date of grant of such Option.

     (c) Exercise. An Option Agreement may provide for exercise of an Option in
such amounts and at such times as shall be specified therein; provided, however,
except as provided in Paragraph 8(e), below, or as otherwise determined by the
Administrator, no Option granted to an Employee may be exercised unless that
person is then in the employ of the Company or a Subsidiary and shall have been
continuously so employed since its date of grant. Except as otherwise permitted
by the Administrator, an Option shall be exercisable by a Participant's giving
written notice of exercise to the Secretary of the Company accompanied by
payment of the required exercise price as set forth in subparagraph (e) hereof.

     (d) General Exercise Period. The Administrator may, in its discretion,
determine the periods during which Options or portions of Options may be
exercised by a Participant. Notwithstanding any limitation on the exercise of
any Option or anything else to the contrary herein contained, except as
otherwise determined by the Administrator at the time of grant, upon the
occurrence of a Change in Control while a Participant is employed by the Company
or a Subsidiary or is a Director, all outstanding Options held by such
Participant shall become immediately exercisable. Notwithstanding the foregoing,
no Option shall be exercisable after the expiration of ten years from its date
of grant. Every Option which has not been exercised within ten years of its date
of grant shall lapse upon the expiration of said ten-year period unless it shall
have lapsed at an earlier date.

     (e) Payment of Exercise Price. The exercise price shall be payable in whole
or in part in cash (including through participation in a broker-assisted
exercise program), Shares held by the Participant or such other consideration
consistent with the Plan's purpose and applicable law as may be determined by
the Administrator from time to time. Unless otherwise determined by the
Administrator, such price shall be paid in full at the time that an Option is
exercised. If the Participant elects to pay all or a part of the exercise price
in Shares, such Participant may make such payment by delivering to the Company a
number of Shares already owned by the Participant, either directly or by
attestation, which are equal in value to the purchase or exercise price. All
Shares so delivered shall be valued at their Fair Market Value on the day on
which such Shares are delivered.

     (f) Cessation of Employee Status. With respect to Participants who are
Employees, except as determined otherwise in the Option Agreement or by the
Administrator:

                                       8

<Page>

          (1) Any Participant who ceases to be an Employee due to Retirement, or
     early retirement with the consent of the Administrator, shall have six (6)
     months from the date of such cessation to exercise any Option granted
     hereunder as to all or part of the Shares subject to such Option; provided,
     however, that no Option shall be exercisable subsequent to ten (10) years
     after its date of grant, and provided further that on the date the
     Participant ceases to be an Employee, he or she then has a present right to
     exercise such Option.

          (2) Any Participant who ceases to be an Employee due to Disability
     shall have six (6) months from the date of such cessation to exercise any
     Option granted hereunder as to all or part of the Shares subject to such
     Option to the extent that such Participant then has a present right to
     exercise such Option; provided, however, that no Option shall be
     exercisable subsequent to ten (10) years after its date of grant.

          (3) In the event of the death of an Employee while an Employee, any
     Option, as to all or any part of the Shares subject to such Option, granted
     to such Employee shall be exercisable:

               (A) for six (6) months after the Employee's death, but in no
          event later than ten (10) years from its date of grant;

               (B) only (1) by the deceased Employee's designated beneficiary
          (such designation to be made in writing at such time and in such
          manner as the Administrator shall approve or prescribe), or, if the
          deceased Employee dies without a surviving designated beneficiary, (2)
          by the personal representative, administrator, or other representative
          of the estate of the deceased Employee, or by the person or persons to
          whom the deceased Employee's rights under the Option shall pass by
          will or the laws of descent and distribution; and

               (C) only to the extent that the deceased Employee would have been
          entitled to exercise such Option on the date of the Employee's death.

          (4) An Employee or former Employee who holds an Option who has
     designated a beneficiary for purposes of Subparagraph 8(e)(3)(B)(1), above,
     may change such designation at any time, by giving written notice to the
     Administrator, subject to such conditions and requirements as the
     Administrator may prescribe in accordance with applicable law.

          (5) If a Participant ceases to be an Employee for a reason other than
     those specified above, that Participant shall have three (3) months from
     the date of such cessation to exercise any Option granted hereunder as to
     all or part of the Shares subject thereto; provided, however, that no
     Option shall be exercisable subsequent to ten (10) years after its date of
     grant, and provided further that on the date the person ceases to be an
     Employee, he or she then has a present right to exercise such Option.
     Notwithstanding the foregoing, if a person ceases to be an Employee because
     of a termination of

                                       9

<Page>

     employment for Cause, to the extent an Option is not effectively exercised
     prior to such cessation, it shall lapse immediately upon such cessation.

     (g) Extension of Periods. The Administrator may in its sole discretion
increase the periods permitted for exercise of an Option if a Participant ceases
to be an Employee as provided in Subparagraphs 8(e)(1), (2), (3) and (5), above,
if allowable under applicable law; provided, however, in no event shall an
Option be exercisable subsequent to ten (10) years after its date of grant.

     (h) Transferability. Except as otherwise provided in the remainder of this
Paragraph 8(h) and the Option Agreement, options granted to a Participant under
this Plan shall not be transferable or subjected to execution, attachment or
similar process, and during the lifetime of the Participant shall be exercisable
only by the Participant. A Participant shall have the right to transfer the
Options granted to such Participant upon such Participant's death, either to the
deceased Participant's designated beneficiary (such designation to be made in
writing at such time and in such manner as the Administrator shall approve or
prescribe), or, if the deceased Participant dies without a surviving designated
beneficiary, by the terms of such Participant's will or under the laws of
descent and distribution, subject to any limitations set forth in this Plan or
otherwise determined by the Administrator, and all such distributees shall be
subject to all terms and conditions of this Plan to the same extent as would the
Participant.

     (i) Nature of Options. No Participant shall have any interest in any fund
or in any specific asset or assets of the Company by reason of any Options
granted hereunder, nor any right to exercise any of the rights or privileges of
a shareholder with respect to any Options until Shares are received in
connection with any exercise.

9. RESTRICTED STOCK

     Restricted Stock granted under this Plan shall be subject to such terms and
conditions not inconsistent with the Plan as the Administrator shall determine,
including the following:

     (a) Grants. The terms of any grant of Restricted Stock shall be confirmed
by the execution of a Restricted Stock Agreement.

     (b) Restrictions. Restricted Stock may not be sold, assigned, conveyed,
donated, pledged, transferred or otherwise disposed of or encumbered for the
period determined by the Administrator (the "Restricted Period"), subject to the
provisions of this Paragraph 9. In the event that a Participant shall sell,
assign, convey, donate, pledge, transfer or otherwise dispose of or encumber the
Restricted Stock, said Restricted Stock shall be forfeited to the Company.

     (c) Cessation of Employee Status. With respect to Participants who are
Employees, except as determined otherwise by the Administrator at the time of
grant:

          (1) If a Participant ceases to be an Employee for any reason, then
     except as provided in Subparagraphs (c)(2) and (d), below, all Restricted
     Stock held by such Participant shall be forfeited to the Company.

                                       10

<Page>

          (2) In the event a Participant ceases to be an Employee on or after
     such person's Retirement, or due to early retirement with the consent of
     the Administrator, or due to death or Disability, all restrictions
     applicable to any Restricted Stock then held by the Participant shall
     immediately lapse.

     (d) Vesting on Change in Control. Except as otherwise set forth in the
Restricted Stock Agreement, and notwithstanding anything to the contrary herein
contained, upon the occurrence of a Change in Control while a Participant is
employed by the Company or a Subsidiary or is a Director, the restrictions
applicable to any Restricted Stock then held by such Participants shall
immediately lapse, and all such Restricted Stock shall be treated as Shares of
the Company and the holders thereof shall be entitled to receive the same
consideration thereupon, if any, payable to the holders of outstanding shares of
the Company in connection with the Change in Control.

     (e) Retention of Certificates. The Company will retain custody of the stock
certificates representing Restricted Stock during the Restricted Period, as well
as a stock power signed by the Participant to be used in the event the
Restricted Stock is forfeited to the Company.

10. SARs

     Each SAR granted under this Plan shall be subject to such terms and
conditions not inconsistent with the Plan as the Administrator shall determine,
including the following:

     (a) Grants. The terms of any grant of SARs shall be confirmed by the
execution of an SAR Agreement.

     (b) Grant Value. The Grant Value of each SAR granted pursuant to this Plan
shall be the Fair Market Value of a Share on the date of grant.

     (c) Exercise. An SAR Agreement may provide for exercise of an SAR by a
Participant in such amounts and at such times as shall be specified therein;
provided, however, except as otherwise determined by the Administrator, no SAR
granted to an Employee may be exercised unless that person is then in the employ
of the Company or a Subsidiary and shall have been continuously so employed
since its date of grant. Except as otherwise permitted by the Administrator, an
SAR shall be exercisable by a Participant by such Participant giving written
notice of exercise to the Secretary of the Company.

     (d) General Exercise Period. The Administrator may, in its discretion,
determine the periods during which SARs may be exercised by a Participant.
Notwithstanding any limitation on the exercise of any SAR or anything else to
the contrary herein contained, except as otherwise determined by the
Administrator at the time of grant, upon the occurrence of a Change in Control
while a Participant is employed by the Company or a Subsidiary or is a Director,
all outstanding SARs held by such Participants shall become immediately
exercisable. Notwithstanding the foregoing, no SAR shall be exercisable after
the expiration of ten years from its date of grant. Every SAR which has not been
exercised within ten years of its date of grant shall lapse upon the expiration
of said ten-year period unless it shall have lapsed at an earlier date.

                                       11

<Page>

     (e) Rights on Exercise. An SAR shall entitle the Participant to receive
from the Company upon exercise a number of Shares determined in accordance with
the following formula. First, determine (a) the excess of the Fair Market Value
of one Share on the date of exercise over (b) the Grant Value for such SAR as
set forth in the applicable SAR Agreement. Second, multiply such excess by(c)
the number of SARs exercised. Third, divide the product by (d) the Fair Market
Value of one Share on the date of exercise to determine the number of Shares to
which the Participant is entitled from the SAR exercise.

     (h) Transferability. Except as otherwise provided in this Paragraph 10(h)
or the SAR Agreement, SARs granted to a Participant under this Plan shall not be
transferable or subjected to execution, attachment or similar process, and
during the lifetime of the Participant shall be exercisable only by the
Participant. A Participant shall have the right to transfer the SARs upon such
Participant's death, either to the deceased Participant's designated beneficiary
(such designation to be made in writing at such time and in such manner as the
Administrator shall approve or prescribe), or, if the deceased Participant dies
without a surviving designated beneficiary, by the terms of such Participant's
will or under the laws of descent and distribution, subject to any limitations
set forth in the Plan or otherwise determined by the Administrator, and all such
distributees shall be subject to all terms and conditions of the Plan to the
same extent as would the Participant.

     (i) Nature of SARs. No Participant shall have any interest in any fund or
in any specific asset or assets of the Company by reason of any SARs granted
hereunder, nor any right to exercise any of the rights or privileges of a
shareholder with respect to any SARs until Shares are received in connection
with any exercise.

11. DEFERRED STOCK

     Deferred Stock granted under this Plan shall be subject to such terms and
conditions not inconsistent with the Plan as the Administrator shall determine,
including the following:

     (a) Grants. The terms of any grant of Deferred Stock shall be confirmed by
the execution of a Deferred Stock Agreement.

     (b) Distributions of Shares. Each Participant who holds Deferred Stock
shall be entitled to receive from the Company one Share for each share of
Deferred Stock, as adjusted from time to time in the manner set forth in
Paragraph 16, below. Deferred Stock shall vest and Shares shall be distributed
to the Participant in respect thereof at such time or times as determined in the
Deferred Stock Agreement; provided, however, that Shares shall only be
distributed in accordance with the rules of Section 409A of the Code and any
guidance issued thereunder (including any delay in distribution required if a
Participant is a specified employee); and provided, further, that no Shares
shall be distributed in respect of Deferred Stock prior to the date on which
such Deferred Stock vests.

     (c) Cessation of Employee Status. With respect to Participants who are
Employees, except as determined otherwise by the Administrator at the time of
grant:

                                       12

<Page>

          (1) If a Participant ceases to be an Employee for any reason, then
     except as provided in Subparagraphs (c)(2) and (d), below, all Deferred
     Stock held by such Participant on the date of termination that has not
     vested shall be forfeited.

          (2) In the event a Participant ceases to be an Employee on or after
     such person's Retirement, or due to early retirement with the consent of
     the Administrator, or due to death or Disability, all Deferred Stock then
     held by such Participant shall immediately vest.

     (d) Vesting on Change in Control. Except as determined in the Deferred
Stock Agreement, notwithstanding anything to the contrary herein contained, upon
the occurrence of a Change in Control while a Participant is employed by the
Company or a Subsidiary or is a Director, all unvested Deferred Stock then held
by such Participants shall immediately vest.

     (e) Transferability. Deferred Stock may not be sold, assigned, conveyed,
donated, pledged, transferred or otherwise disposed of or encumbered or
subjected to execution, attachment, or similar process; provided, however,
Shares distributed in respect of such Deferred Stock may be transferred in
accordance with applicable securities laws. A Participant shall have the right
to transfer Deferred Stock upon such Participant's death, either to the deceased
Participant's designated beneficiary (such designation to be made in writing at
such time and in such manner as the Administrator shall prescribe or approve),
or, if the deceased Participant dies without a surviving designated beneficiary,
by the terms of such Participant's will or under the laws of descent and
distribution, subject to any limitations set forth in the Plan or otherwise
determined by the Administrator, and all such distributees shall be subject to
all terms and conditions of the Plan to the same extent as would the
Participant.

     (f) No Rights as Shareholders. No Participant shall have any interest in
any fund or in any specific asset or assets of the Company by reason of any
Deferred Stock granted hereunder, nor any right to exercise any of the rights or
privileges of a shareholder with respect to any Deferred Stock or any Shares
distributable with respect to any Deferred Stock until such Shares are so
distributed.

     (g) Dividends and Distributions. As of each record date for the payment of
dividends on the Company's Shares, each Participant shall be granted a number of
additional shares of Deferred Stock equal to the quotient of the amount of
dividends which would have been received by a shareholder of record of a number
of Shares equal to the number of shares of Deferred Stock held by such
Participant immediately before such dividend, divided by the Fair Market Value
of a Share on such date. In the event of any distribution with respect to Shares
other than a cash dividend, then each Participant shall be granted a number of
additional shares of Deferred Stock which could have been purchased at the Fair
Market Value as of the date of such distribution with an amount equal to the
Fair Market Value of the consideration which would have been received on such
date by a shareholder of record of a number of Shares equal to the number of
shares of Deferred Stock then held by such Participant.

                                       13

<Page>

12. PERFORMANCE SHARES

          Performance Shares granted under this Plan shall be subject to such
terms and conditions not inconsistent with the Plan as the Administrator shall
determine, including the following:

     (a) Nature of Performance Shares. The grant of any Performance Shares
entitles the Participant to be granted Shares upon the attainment of performance
goals specified in the Performance Shares Agreement. The Administrator in its
sole discretion shall determine the performance goals applicable to each Award
of Performance Shares, the periods during which performance is to be measured,
and all other limitations and conditions applicable to the awarded Performance
Shares. Shares underlying any Award of Performance Shares shall be adjusted from
time to time in the manner set forth in Paragraph 16 below.

     (b) Rights as Shareholder. A Participant receiving an Award of Performance
Shares shall have the rights of a shareholder only as to Shares actually
received by the Participant under the Plan upon the attainment of specified
performance goals and not with respect to Shares subject to the Award but not
actually received by the Participant. A Participant shall be entitled to receive
Shares only upon attainment of specified performance goals within the period
specified in the Performance Shares Agreement.

     (c) Cessation of Employee Status. With respect to Participants who are
Employees, except as determined otherwise by the Administrator at the time of
grant, if such a Participant ceases to be an Employee for any reason, all
Performance Shares held by such Participant on the date of termination that have
not vested shall be forfeited.

     (d) Vesting on Change in Control. Except as determined in the Performance
Shares Agreement, notwithstanding anything to the contrary herein contained,
upon the occurrence of a Change in Control while a Participant is employed by
the Company or a Subsidiary or is a Director, all unvested Deferred Stock then
held by such Participant shall immediately vest.

     (e) Transferability. Deferred Stock may not be sold, assigned, conveyed,
donated, pledged, transferred or otherwise disposed of or encumbered or
subjected to execution, attachment, or similar process; provided, however,
Shares distributed in respect of such Performance Shares may be transferred in
accordance with applicable securities laws.

13. FOREIGN AWARD RECIPIENTS

     Notwithstanding any provision of the Plan to the contrary, in order to
comply with the laws in other countries in which the Company and its
Subsidiaries operate or have Employees, the Administrator, in its sole
discretion, shall have the power and authority to: (i) determine which
Subsidiaries shall be covered by the Plan; (ii) determine which individuals
outside the United States are eligible to participate in the Plan; (iii) modify
the terms and conditions of any Award granted to individuals outside the United
States to comply with applicable foreign laws; (iv) establish subplans and
modify exercise procedures and other terms and procedures, to the extent the
Committee determines such actions to be necessary or advisable (and such
subplans

                                       14

<Page>

and/or modifications shall be attached to this Plan as appendices); provided,
however, that no such subplans and/or modifications shall increase the share
limitations contained in Section 4(a) hereof; and (v) take any action, before or
after an Award is made, that the Committee determines to be necessary or
advisable to obtain approval or comply with any local governmental regulatory
exemptions or approvals.

14. LAWS AND REGULATIONS

     Each Option Agreement, Restricted Stock Agreement, SAR Agreement, Deferred
Stock Agreement or Performance Shares Agreement shall contain such
representations, warranties and other terms and conditions as shall be necessary
in the opinion of counsel to the Company to comply with all applicable federal
and state securities laws. The Company shall have the right to delay the issue
or delivery of any Shares under the Plan until (a) the completion of such
registration or qualification of such Shares under any federal or state law,
ruling or regulation as the Company shall determine to be necessary or
advisable, and (b) receipt from the Participant of such documents and
information as the Administrator may deem necessary or appropriate in connection
with such registration or qualification.

15. CLAIMS PROCEDURE

     An Employee who believes that he/she is being denied a benefit to which
he/she is entitled under this Plan (hereinafter referred to as "Claimant") may
file a written request for such benefit with the Administrator setting forth
his/her claim. The request must be addressed to the secretary of the Company at
its principal place of business.

     A written notice of a claim denial will be sent within a reasonable time
after the Administrator receives a claim, but not later than 90 days after
receipt. If a decision cannot be made within 90 days after the Administrator
receives the claim, the Administrator may extend the initial review period as
permitted under U.S. Department of Labor regulations. The Administrator will
provide timely notice of the extension to the Claimant, explaining the
unresolved issues that prevent a decision on the claim, and the date the
Administrator expects to make its decision.

     If the claim is denied, the Administrator will inform the Claimant in
writing, setting forth: (i) the specified reason(s) for the denial; (ii)
reference to the Plan provisions on which the denial is based; (iii) a
description of any additional information necessary to perfect the claim; and
(iv) a description of the Plan's review procedures.

     The Claimant may request in writing a review of the denial within 60 days
after receiving the notice of denial. Such request must be addressed to the
secretary of the Company at its principal place of business. The Claimant may
submit written information relating to the claim, and may request copies of all
relevant information, free of charge.

     The Administrator will review the claim on receipt of the written request
for review, and will notify the Claimant of its decision within a reasonable
time but not later than 60 days after the request has been received. If an
extension of time is required to process the claim, the

                                       15

<Page>

Administrator will notify the Claimant in writing of the special circumstances
requiring the extension and the date by which the Administrator expects to make
a determination on review. The extension cannot exceed a period of 60 days from
the end of the first review period.

     The Administrator will provide the Claimant with written notice of its
decision on review. If the decision is adverse, the notice will set forth: (i)
the specified reason(s) for the denial; (ii) reference to the Plan provisions on
which the denial is based; (iii) a statement that the Claimant may receive, upon
request and free of charge, reasonable access to all information relevant to the
claim; and (iv) a statement of the Claimant's right to bring an action under
ERISA Section 502(a).

16. ADJUSTMENT PROVISIONS

     (a) Share Adjustments. In the event of any stock dividend, stock split,
recapitalization, merger, consolidation, combination or exchange of shares, or
the like, as a result of which shares of any class shall be issued in respect of
the outstanding Shares, or the Shares shall be changed into the same or a
different number of the same or another class of stock, or into securities of
another person, any distribution of cash or other property to the shareholders
(other than a regular cash dividend), the total number of Shares authorized to
be offered in accordance with Paragraph 4 and the other limitations contained in
Paragraph 4, the number of Shares subject to each outstanding Option, the number
of Shares of Restricted Stock then held by each Participant, the number of
shares to which each then outstanding SAR or Award of Deferred Stock or
Performance Shares relates, the exercise price applicable to each outstanding
Option and the Grant Value of each outstanding SAR shall be adjusted in such
equitable and proportionate manner as determined by the Administrator. No
fractional Share shall be issued under the Plan resulting from any such
adjustment but the Administrator in its discretion may make a cash payment in
lieu of a fractional Share.

     (b) Acquisitions. In the event of a merger or consolidation of the Company
with another corporation or entity in which the Company is not the survivor, or
a sale or disposition by the Company of all or substantially all of its assets,
the Administrator shall, in its sole discretion, have authority to provide for
(1) waiver in whole or in part of any remaining restrictions or vesting
requirements in connection with any Award granted hereunder, (2) the conversion
of outstanding Options, Restricted Stock, SARs, Deferred Stock or Performance
Shares into cash and/or (3) the conversion of Awards into the right to receive
securities of another person upon such terms and conditions as are determined by
the Administrator in its discretion.

     (c) Binding Effect. Any adjustment, waiver, conversion or other action
taken by the Administrator under this Paragraph 16 shall be conclusive and
binding on all Participants.

17. TAXES

     (a) Options and SARs. The Company shall be entitled to pay and withhold
from any amounts payable by the Company to a Participant the amount of any tax
which it believes is required as a result of the grant, vesting or exercise of
any Option or SAR, and the Company may defer making delivery with respect to
Shares obtained pursuant to exercise of any Option or

                                       16

<Page>

SAR until arrangements satisfactory to it have been made with respect to any
such withholding obligations. The tax withheld will not exceed the minimum
required by law. If the Company agrees, a Participant exercising an Option may,
at his or her election, satisfy his or her obligation for payment of required
withholding taxes by having the Company retain a number of Shares having an
aggregate Fair Market Value on the date the Shares are withheld equal to the
amount of the required withholding tax at the minimum rate required by law. If
the Company is not agreeable to accepting Shares, the Participant must transfer
cash to the Company equal to the withholding obligation.

     (b) Restricted Stock. The Company shall be entitled to pay and withhold
from any amounts payable by the Company to a Participant the amount of any tax
which it believes is required as a result of the issuance of or lapse of
restrictions on Restricted Stock, and the Company may defer the delivery of any
Shares or Share certificates until arrangements satisfactory to the
Administrator shall have been made with respect to any such withholding
obligations. The tax withheld will not exceed the minimum required by law. If
the Company agrees, a Participant may, at his or her election, satisfy his or
her obligation for payment of required withholding taxes with respect to
Restricted Stock by delivering to the Company a number of Shares which were
Restricted Stock upon the lapse of restrictions, or Shares already owned, having
an aggregate Fair Market Value on the date the Shares are withheld equal to the
amount of the required withholding tax at the minimum rate required by law. If
the Company is not agreeable to accepting Shares, the Participant must transfer
cash to the Company equal to the withholding obligation.

     (c) Deferred Stock. The Company shall be entitled to pay and withhold from
any amounts payable by the Company to a Participant the amount of any tax which
it believes is required as a result of the vesting of any Deferred Stock or the
distribution of any Shares with respect to Deferred Stock, and the Company may
defer making delivery of Shares with respect to Deferred Stock until
arrangements satisfactory to the Administrator have been made with respect to
any such withholding obligations. The tax withheld will not exceed the minimum
required by law. If the Company agrees, a Participant who holds Deferred Stock
may, at his or her election, satisfy his or her obligation to pay the required
withholding taxes by having the Company withhold from the number of Shares
distributable, a number of Shares having an aggregate Fair Market Value on the
date the Shares are withheld equal to the amount of the required withholding tax
at the minimum rate required by law. If the Company is not agreeable to
accepting Shares, the Participant must transfer cash to the Company equal to the
withholding obligation.

     (d) Performance Shares. The Company shall be entitled to pay and withhold
from any amounts payable by the Company to a Participant the amount of any tax
which it believes is required as a result of the vesting of any Performance
Shares or the distribution of any Shares with respect to Performance Shares, and
the Company may defer making delivery of Shares with respect to Performance
Shares until arrangements satisfactory to the Administrator have been made with
respect to any such withholding obligations. The tax withheld will not exceed
the minimum required by law. If the Company agrees, a Participant who holds
Performance Shares may, at his or her election, satisfy his or her obligation to
pay the required withholding taxes by

                                       17

<Page>

having the Company withhold from the number of Shares distributable, a number of
Shares having an aggregate Fair Market Value on the date the Shares are withheld
equal to the amount of the required withholding tax at the minimum rate required
by law. If the Company is not agreeable to accepting Shares, the Participant
must transfer cash to the Company equal to the withholding obligation.

18. EFFECTIVENESS OF THE PLAN

     The Plan, as approved by the Company's Board of Directors, shall become
effective as of the date of such approval, and any amendment and/or restatement
of the Plan shall become effective as of the date of approval by the Company's
Board of Directors, except if any amendment or restatement is subject to
shareholder approval in which event the date of shareholder approval shall be
the effective date.

19. TERMINATION AND AMENDMENT

     Unless the Plan shall theretofore have been terminated as hereinafter
provided, no Award shall be granted after the tenth anniversary of the date this
Plan is approved by the Board of Directors. The Board of Directors may terminate
the Plan or make such modifications or amendments thereof as it shall deem
advisable, including, but not limited to, such modifications or amendments as it
shall deem advisable in order to conform to any law or regulation applicable
thereto. No termination, modification or amendment of the Plan may, without the
consent of the Participant, adversely affect the rights of such Participant
under an outstanding Award then held by the Participant. Notwithstanding the
foregoing, the Company must obtain shareholder approval of (a) any amendment to
the extent such approval is required by the exchange or interdealer quotation
system on which the Shares are listed, or (b) any amendment which results in any
Option or SAR being granted at an exercise price other than Fair Market Value.

     Except as otherwise provided in this Plan, the Administrator may amend an
outstanding Award or any Option Agreement, Restricted Stock Agreement, SAR
Agreement, Deferred Stock Agreement or Performance Shares Agreement; provided,
however, that the Participant's consent to such action shall be required unless
the Administrator determines that the action, taking into account any related
action, would not adversely affect the Participant. The Administrator may also
modify or amend the terms of any Award granted under the Plan for the purpose of
complying with, or taking advantage of, income or other tax or legal
requirements or practices of foreign countries which are applicable to
Employees. However, notwithstanding any other provision of the Plan, the
Administrator may not adjust or amend the exercise price of any outstanding
Option or SAR, whether through amendment, cancellation and replacement grants,
or any other means, except in accordance with Paragraph 16 of the Plan, without
shareholder approval.

     Notwithstanding the above to the contrary, the Board of Directors or the
Administrator may amend the Plan or any Award at any time, without the consent
of any Participant, in order to cause the Plan or such Award Agreement to meet
the requirements of Section 409A of the Code and any guidance promulgated
thereunder in order to avoid causing any Participant to become

                                       18

<Page>

subject to interest and/or penalties that would otherwise by imposed under
Section 409A of the Code. In the event this Plan is terminated, any amounts
allocated to a Participant hereunder that are subject to Section 409A of the
Code shall be distributed to the Participants only in a manner permitted under
Section 409A of the Code and any guidance promulgated thereunder.

20. OTHER BENEFIT AND COMPENSATION PROGRAMS

     Payments and other benefits received by an Employee under an Award granted
pursuant to the Plan shall not be deemed a part of such Employee's regular,
recurring compensation for purposes of the termination, indemnity or severance
pay law of any country and shall not be included in, nor have any effect on, the
determination of benefits under any other Employee benefit plan, contract or
similar arrangement provided by the Company or any Subsidiary unless expressly
so provided by such other plan, contract or arrangement, unless required by law,
or unless the Administrator expressly determines otherwise. The adoption of the
Plan shall not be construed as creating any limitations on the power of the
Board of Directors or the Administrator to adopt such other compensation
arrangement as it may deem desirable for any Participant.

21. NO RIGHT TO EMPLOYMENT.

     The Plan shall not confer upon any person any right with respect to
continuation of employment by the Company or a Subsidiary, nor shall it
interfere in any way with the right of the Company or such Subsidiary to
terminate any person's employment at any time.

22. SEVERABILITY.

     In the event any provision of this Plan shall be held illegal or invalid
for any reason, the illegality or invalidity shall not affect the remaining
parts of the Plan, and this Plan shall be construed and enforced as if the
illegal or invalid provision had not been included.

23. GOVERNING LAW.

     This Plan and all Awards and actions taken thereunder shall be governed by,
and construed in accordance with, the laws of the State of Delaware, applied
without regard to conflict of law principles.

                                       19

<Page>

                                   PICIS, INC.
                           2005 EQUITY INCENTIVE PLAN
                                 AWARD AGREEMENT

                             INCENTIVE STOCK OPTION

                                     PART I
                         NOTICE OF GRANT OF STOCK OPTION

     We are pleased to inform you that you have been granted a Stock Option to
purchase shares of Common Stock of PICIS, Inc., subject to the terms and
conditions of the PICIS, Inc. 2005 Equity Incentive Plan (the "Plan") and of
this Award Agreement. Unless otherwise defined herein, all terms used in this
Award Agreement shall have the same meanings as set forth in the Plan.

     Name of Participant:

     Award Number:

     Total number of option shares:

     Exercise price per share(1):

     Total exercise price:

     Date of Grant:

     Date of Expiration(2):

     1. Vesting Schedule. No portion of this Stock Option may be exercised until
such portion shall have become exercisable. Except as set forth below, and
subject to the discretion of the Administrator (as defined in Section 2 of the
Plan) to accelerate the exercisability schedule hereunder, the Stock Option
granted pursuant to this Award will vest according to the following schedule,
provided, however, that you must be employed by the Company on each vesting date
for that portion of the Stock Option to vest:

  Incremental Number of
Option Shares Exercisable*   Vesting Date
--------------------------   ------------
     ______     (___%)          ______
     ______     (___%)          ______
     ______     (___%)          ______
     ______     (___%)          ______

* Max. of $100,000 per yr.

----------
(1)  FMV ON GRANT DATE (110% OF FMV IF A 10% OWNER)

(2)  NO MORE THAN 10 YEARS

<Page>

     Once exercisable, this Stock Option shall continue to be exercisable at any
time or times prior to the close of business on the Expiration Date, subject to
the provisions of this Award Agreement and of the Plan.

     2. Status of the Stock Option. This Stock Option is intended to qualify as
an "incentive stock option" under Section 422 of the Internal Revenue Code of
1986, as amended (the "Code"), but the Company does not represent or warrant
that this Stock Option qualifies as such. You should consult with your own tax
advisors regarding the tax effects of this Stock Option and the requirements
necessary to obtain favorable income tax treatment under Section 422 of the
Code, including, but not limited to, holding period requirements. To the extent
any portion of this Stock Option does not so qualify as an "incentive stock
option," such portion shall be deemed to be a non-qualified stock option. If you
intend to dispose or do dispose (whether by sale, gift, transfer or otherwise)
of any option shares within the one-year period beginning on the date after the
transfer of such shares to you, or within the two-year period beginning on the
day after the grant of this Stock Option, you agree to so notify the Company
within 30 days after such disposition.

     3. Accelerated Vesting. If a Change in Control occurs while you are
employed by the Company or a Subsidiary, the unvested portion of this Stock
Option will become immediately vested and exercisable.

     4. Expiration Date. In all events, and notwithstanding anything herein
contained to the contrary, this Stock Option shall expire no later than the
Expiration Date.

     By your signature and the signature of the Company's representative below,
you and the Company agree that the Stock Option which has been awarded to you
under this Award Agreement is subject to the terms and conditions of the Plan
which is attached hereto as Exhibit A. As provided in the Plan, you hereby agree
to accept as binding any decision of the Administrator with respect to the
interpretation of the Plan and this Award Agreement, or any other matters
associated therewith. You further agree to notify the Company as soon as
possible upon any change in your residential address. By your signature below,
you certify that you do not hold more than 10% of the voting rights of any type
of securities issued by the Company, and that consequently the Stock Option
awarded pursuant to the Award Agreement may be considered an incentive stock
option, if all of the requirements of Code Section 422 are met.

     IN WITNESS WHEREOF, the Company has caused these presents to be executed as
of the Date of Grant set forth above:

                                        PICIS, INC.

                                        By:
                                            ------------------------------------
                                            Todd Cozzens

     The undersigned Participant hereby accepts the foregoing Stock Option and
agrees to the terms and conditions of this Award Agreement and of the Plan.

                                        ----------------------------------------
                                        [INSERT NAME OF PARTICIPANT]

<Page>

                                   PICIS, INC.
                           2005 EQUITY INCENTIVE PLAN
                                 AWARD AGREEMENT

                             INCENTIVE STOCK OPTION

                                     PART II
                     TERMS AND CONDITIONS OF AWARD AGREEMENT

                                    ARTICLE I
                              Award of Stock Option

     1.1. Grant of Stock Option. Pursuant to the PICIS, Inc. 2005 Equity
Incentive Plan as amended through the date hereof (the "Plan"), PICIS, Inc. (the
"Company") hereby grants to the Participant named in Part I of this Award
Agreement an option (the "Stock Option") to purchase on or prior to the
Expiration Date specified above all or part of the number of shares of Common
Stock, par value $0.01 per share (the "Stock"), of the Company specified in the
Notice of Grant at the Option Exercise Price per Share specified in the Notice
of Grant subject to the terms and conditions set forth herein and in the Plan.

     1.2 Time Limitations on Exercise of Stock Option. Except as otherwise
provided in the Plan, and subject to Section 1.3 below, the Stock Option granted
pursuant to this Award Agreement is exercisable, in whole or in part, from the
Vesting Date to the Expiration Date as set forth in the Notice of Grant.

     1.3 Termination of Employment Relationship. The Stock Option shall be
exercisable upon the termination of the Participant's employment relationship
with the Company and its affiliates only in the manner and to the extent
provided in Section 8(f) of the Plan, as modified herein. This Stock Option, to
the extent vested on termination of employment, shall remain exercisable for a
period of six (6) months after the Participant's death or Disability as defined
in the Plan. In all other cases, the Stock Option, to the extent vested on
termination of employment, shall be exercisable for ninety (90) days following
the termination of the Participant's employment for any reason other than Cause.
The exercise of this Stock Option following termination of employment or
cessation of service on the Board of Directors shall be expressly subject to
compliance with the Participant's obligations under any agreement with the
Company regarding proprietary information, inventions, confidentiality or
non-competition. If a Participant's employment is terminated for Cause, the
Stock Option shall expire immediately. Any unvested portion of this Stock Option
shall expire immediately upon Participant's termination of employment for any
reason. In all events, and notwithstanding anything herein contained to the
contrary, this Stock Option shall expire no later than the Expiration Date as
set forth in the Notice of Grant.

     1.4. Method of Exercising Stock Option. The Stock Option may be exercised
in whole or in part by delivery to the Company, at its offices in Wakefield, MA,
of (a) a written notice identifying the Stock Option and stating the number of
shares with respect to which it is being exercised, and (b) payment in full of
the exercise price of the shares then being acquired in the form permitted by
Section 1.5 of this Award Agreement. The written notice shall be signed by the
Participant and shall be delivered to the Company in person, by certified mail
with return receipt requested, by facsimile, or electronically. The Company
shall have the right to delay the issue or delivery of any shares to be
delivered hereunder until (a) the completion of such registration or
qualification of such shares under federal, state or foreign law, ruling or
regulation as the Company shall deem to be necessary or advisable, (b) receipt
from the Participant of such documents and information as the Company may deem
necessary or appropriate in connection with such registration or qualification
or the issuance of shares hereunder, and (c)

<Page>

arrangements satisfactory to the Company have been made with regard to any tax
withholding obligations the Company believes is required as a result of the
exercise of the Stock Option.

     1.5. Methods of Payment.

          (a) Payment of the exercise price for the shares of Common Stock which
     are being purchased pursuant to the exercise of the Stock Option shall be
     made using any of the following means of payment, at the election of the
     Participant:

               (i) in cash, by certified or bank check or other instrument
     acceptable to the Administrator, including wire transfer;

               (ii) through the delivery (or attestation to the ownership) of
     shares of Stock that have been purchased by the Participant on the open
     market or that are beneficially owned by the Participant and are not then
     subject to any restrictions under any Company plan;

               (iii) by the Participant delivering to the Company a properly
     executed exercise notice together with irrevocable instructions to a broker
     to promptly deliver to the Company cash or a check payable and acceptable
     to the Company to pay the option purchase price, provided that in the event
     the Participant chooses to pay the option purchase price as so provided,
     the Participant and the broker shall comply with such procedures and enter
     into such agreements of indemnity and other agreements as the Administrator
     shall prescribe as a condition of such payment procedure; or

               (iv) a combination of (i), (ii) and (iii) above.

     Payment instruments will be received subject to collection.

     The transfer to the Participant on the records of the Company or of the
transfer agent of the shares of common stock will be contingent upon the
Company's receipt from the Participant of full payment for the shares of common
stock, as set forth above and any agreement, statement or other evidence that
the Company may require to satisfy itself that the issuance of Common Stock
pursuant to the exercise of stock options under the Plan and any subsequent
resale of the shares of Common Stock will be in compliance with applicable laws
and regulations. In the event the Participant chooses to pay the purchase price
by previously-owned shares of Common Stock through the attestation method, the
number of shares of Stock transferred to the Participant upon the exercise of
the Stock Option shall be net of the shares attested to.

          (b) The minimum number of shares with respect to which this Stock
     Option may be exercised at any one time shall be 100 shares, unless the
     number of shares with respect to which this Stock Option is being exercised
     is the total number of shares subject to exercise under this Stock Option
     at the time.

     1.6. Prohibitions Against Transfer. This Stock Option, is personal to the
Participant and the rights and privileges conferred hereby, may not be
transferred, assigned, pledged or hypothecated in any way (whether by operation
of law or otherwise) by the Participant, or be subject to execution, attachment
or similar process. This Stock Option is exercisable ,during the Participant's
lifetime, only by the Participant, and thereafter, only as provided in Section
8(f) of the Plan.

<Page>

                                   ARTICLE II
                                  Miscellaneous

     2.1. Provisions of the Plan Control. Notwithstanding anything herein to the
contrary, this Stock Option shall be subject to and governed by all the terms
and conditions of the Plan, including the powers of the Administrator set forth
in Section 5 of the Plan. Capitalized terms in this Award Agreement shall have
the meaning specified in the Plan, unless a different meaning is specified
herein. In the event that the provisions of this Award Agreement and the Plan
conflict, the Plan shall control.

     2.2. Taxes. The Participant shall, not later than the date as of which the
exercise of this Stock Option becomes a taxable event for Federal income tax
purposes, pay to the Company or make arrangements satisfactory to the
Administrator for payment of any Federal, state, and local taxes required by law
to be withheld on account of such taxable event. The Participant may elect to
have the minimum required tax withholding obligation satisfied, in whole or in
part, by (i) authorizing the Company to withhold from shares of Common Stock to
be issued, or (ii) transferring to the Company a number of shares of Common
Stock with an aggregate Fair Market Value that would satisfy the withholding
amount due.

     2.3. Notices. Notices hereunder shall be mailed or delivered to the Company
at its principal place of business and shall be mailed or delivered to the
Participant at the address on file with the Company or, in either case, at such
other address as one party may subsequently furnish to the other party in
writing. Any such notice shall be deemed to have been duly given if and when
actually received by the party to whom it is addressed, as evidenced by a
written receipt to that effect.

     2.4. No Obligation to Continue Employment. Neither the Company nor any
Subsidiary is obligated by or as a result of the Plan or this Award Agreement to
continue the Participant in employment and neither the Plan nor this Agreement
shall interfere in any way with the right of the Company or any Subsidiary to
terminate the employment of the Participant at any time.

     2.5. Governing Law. This Award Agreement and all questions arising
hereunder or in connection herewith shall be determined in accordance with the
laws of the State of Delaware, without giving effect to the principles of
conflicts of laws.

<Page>

                                   PICIS, INC.
                           2005 EQUITY INCENTIVE PLAN
                                 AWARD AGREEMENT

                         NON-QUALIFIED STOCK OPTION(1)

                                     PART I
                         NOTICE OF GRANT OF STOCK OPTION

     We are pleased to inform you that you have been granted a Stock Option to
purchase shares of Common Stock of PICIS, Inc., subject to the terms and
conditions of the PICIS, Inc. 2005 Equity Incentive Plan (the "Plan") and of
this Award Agreement. Unless otherwise defined herein, all terms used in this
Award Agreement shall have the same meanings as set forth in the Plan.

     Name of Participant:

     Award Number:

     Total number of option shares:

     Exercise price per share(2):

     Total exercise price:

     Date of Grant:

     Date of Expiration(3):

     1. Vesting Schedule. No portion of this Stock Option may be exercised until
such portion shall have become exercisable. Except as set forth below, and
subject to the discretion of the Administrator (as defined in Section 2 of the
Plan) to accelerate the exercisability schedule hereunder, the Stock Option
granted pursuant to this Award will vest according to the following schedule,
provided, however, that you must be employed by the Company on each vesting date
for that portion of the Stock Option to vest:

  INCREMENTAL NUMBER OF
OPTION SHARES EXERCISABLE   VESTING DATE
-------------------------   ------------
     ______     (___%)         ______
     ______     (___%)         ______
     ______     (___%)         ______
     ______     (___%)         ______

----------
(1)  This form is not designed to be modified for awards to consultants. If
     awards are to be made to consultants, please consult legal counsel.

(2)  Fair Market Value on the Grant Date.

(3)  No more than 10 years.

<Page>

     Once exercisable, this Stock Option shall continue to be exercisable at any
time or times prior to the close of business on the Expiration Date, subject to
the provisions of this Award Agreement and of the Plan.

     2. Status of the Stock Option. This Stock Option is not intended to be an
"incentive stock option" under Section 422 of the Internal Revenue Code of 1986,
as amended.

     3. Accelerated Vesting. If a Change in Control occurs while you are
employed by the Company or a Subsidiary, the unvested portion of this Stock
Option will become immediately vested and exercisable.

     4. Expiration Date. In all events, and notwithstanding anything herein
contained to the contrary, this Stock Option shall expire no later than the
Expiration Date.

     By your signature and the signature of the Company's representative below,
you and the Company agree that the Stock Option which has been awarded to you
under this Award Agreement is subject to the terms and conditions of the Plan
which is attached hereto as Exhibit A. As provided in the Plan, you hereby agree
to accept as binding any decision of the Administrator with respect to the
interpretation of the Plan and this Award Agreement, or any other matters
associated therewith. You further agree to notify the Company as soon as
possible upon any change in your residential address.

     IN WITNESS WHEREOF, the Company has caused these presents to be executed as
of the Date of Grant set forth above:

                                        PICIS, INC.

                                        By:
                                            ------------------------------------
                                            Todd Cozzens

     The undersigned Participant hereby accepts the foregoing Stock Option and
agrees to the terms and conditions of this Award Agreement and of the Plan.

                                        ----------------------------------------
                                        [INSERT NAME OF PARTICIPANT]

<Page>

                                   PICIS, INC.
                           2005 EQUITY INCENTIVE PLAN
                                 AWARD AGREEMENT

                           NON-QUALIFIED STOCK OPTION

                                     PART II
                     TERMS AND CONDITIONS OF AWARD AGREEMENT

                                    ARTICLE I
                              Award of Stock Option

     1.1. Grant of Stock Option. Pursuant to the PICIS, Inc. 2005 Equity
Incentive Plan as amended through the date hereof (the "Plan"), PICIS, Inc. (the
"Company") hereby grants to the Participant named in Part I of this Award
Agreement an option (the "Stock Option") to purchase on or prior to the
Expiration Date specified above all or part of the number of shares of Common
Stock, par value $0.01 per share (the "Stock"), of the Company specified in the
Notice of Grant at the Option Exercise Price per Share specified in the Notice
of Grant subject to the terms and conditions set forth herein and in the Plan.

     1.2 Time Limitations on Exercise of Stock Option. Except as otherwise
provided in the Plan, and subject to Section 1.3 below, the Stock Option granted
pursuant to this Award Agreement is exercisable, in whole or in part, from the
Vesting Date to the Expiration Date as set forth in the Notice of Grant.

     1.3 Termination of Employment or Service Relationship. The Stock Option
shall be exercisable upon the termination of the Participant's employment
relationship with the Company and its affiliates or upon the Participant's
ceasing to serve as a Director on the Board of Directors only in the manner and
to the extent provided in Section 8(f) of the Plan, as modified herein. This
Stock Option, to the extent vested on termination of employment, shall remain
exercisable for a period of six (6) months after the Participant's death or
Disability as defined in the Plan. In all other cases, the Stock Option, to the
extent vested on termination of employment, shall be exercisable for ninety (90)
days following the termination of the Participant's employment or service for
any reason other than Cause. Upon the termination of the Director's services a
Director, the Stock Option, to the extent then vested, shall remain exercisable
for one (1) year following the termination of the Director's service; but in no
event shall the Stock Option be exercisable beyond the date that is 10 years
after its Grant Date. The exercise of this Stock Option following termination of
employment or cessation of service on the Board of Directors shall be expressly
subject to compliance with the Participant's obligations under any agreement
with the Company regarding proprietary information, inventions, confidentiality
or non-competition. If a Participant's employment or service is terminated for
Cause, the Stock Option shall expire immediately. Any unvested portion of this
Stock Option shall expire immediately upon Participant's termination of
employment or service for any reason. With respect to service as a Director on
the Board of Directors, notwithstanding anything contained herein to the
contrary, the Stock Option shall become fully vested and immediately exercisable
if the Director (i) is serving as a director of the Company upon the Director's
death, Disability, Retirement, or upon a Change of Control or (ii) is not
re-elected to serve as a director of the Company upon the expiration of his or
her term as a Director, but is in good standing upon the expiration of such
term. In all events, and notwithstanding anything herein contained to the
contrary, this Stock Option shall expire no later than the Expiration Date as
set forth in the Notice of Grant.

     1.4. Method of Exercising Stock Option. The Stock Option may be exercised
in whole or in part by delivery to the Company, at its offices in Wakefield, MA,
of (a) a written notice identifying the Stock

<Page>

Option and stating the number of shares with respect to which it is being
exercised, and (b) payment in full of the exercise price of the shares then
being acquired in the form permitted by Section 1.5 of this Award Agreement. The
written notice shall be signed by the Participant and shall be delivered to the
Company in person, by certified mail with return receipt requested, by
facsimile, or electronically. The Company shall have the right to delay the
issue or delivery of any shares to be delivered hereunder until (a) the
completion of such registration or qualification of such shares under federal,
state or foreign law, ruling or regulation as the Company shall deem to be
necessary or advisable, (b) receipt from the Participant of such documents and
information as the Company may deem necessary or appropriate in connection with
such registration or qualification or the issuance of shares hereunder, and (c)
arrangements satisfactory to the Company have been made with regard to any tax
withholding obligations the Company believes is required as a result of the
exercise of the Stock Option.

     1.5. Methods of Payment.

          (a) Payment of the exercise price for the shares of Common Stock which
     are being purchased pursuant to the exercise of the Stock Option shall be
     made using any of the following means of payment, at the election of the
     Participant:

               (i) in cash, by certified or bank check or other instrument
     acceptable to the Administrator, including wire transfer;

               (ii) through the delivery (or attestation to the ownership) of
     shares of Stock that have been purchased by the Participant on the open
     market or that are beneficially owned by the Participant and are not then
     subject to any restrictions under any Company plan;

               (iii) by the Participant delivering to the Company a properly
     executed exercise notice together with irrevocable instructions to a broker
     to promptly deliver to the Company cash or a check payable and acceptable
     to the Company to pay the option purchase price, provided that in the event
     the Participant chooses to pay the option purchase price as so provided,
     the Participant and the broker shall comply with such procedures and enter
     into such agreements of indemnity and other agreements as the Administrator
     shall prescribe as a condition of such payment procedure; or

               (iv) a combination of (i), (ii) and (iii) above.

     Payment instruments will be received subject to collection.

     The transfer to the Participant on the records of the Company or of the
transfer agent of the shares of common stock will be contingent upon the
Company's receipt from the Participant of full payment for the shares of common
stock, as set forth above and any agreement, statement or other evidence that
the Company may require to satisfy itself that the issuance of Common Stock
pursuant to the exercise of stock options under the Plan and any subsequent
resale of the shares of Common Stock will be in compliance with applicable laws
and regulations. In the event the Participant chooses to pay the purchase price
by previously-owned shares of Common Stock through the attestation method, the
number of shares of Stock transferred to the Participant upon the exercise of
the Stock Option shall be net of the shares attested to.

          (b) The minimum number of shares with respect to which this Stock
     Option may be exercised at any one time shall be 100 shares, unless the
     number of shares with respect to which this Stock Option is being exercised
     is the total number of shares subject to exercise under this Stock Option
     at the time.

<Page>

     1.6. Prohibitions Against Transfer. This Stock Option, is personal to the
Participant and the rights and privileges conferred hereby, may not be
transferred, assigned, pledged or hypothecated in any way (whether by operation
of law or otherwise) by the Participant, or be subject to execution, attachment
or similar process. This Stock Option is exercisable, during the Participant's
lifetime, only by the Participant, and thereafter, only as provided in Section
8(f) of the Plan.

                                   ARTICLE II
                                  Miscellaneous

     2.1. Provisions of the Plan Control. Notwithstanding anything herein to the
contrary, this Stock Option shall be subject to and governed by all the terms
and conditions of the Plan, including the powers of the Administrator set forth
in Section 5 of the Plan. Capitalized terms in this Award Agreement shall have
the meaning specified in the Plan, unless a different meaning is specified
herein. In the event that the provisions of this Award Agreement and the Plan
conflict, the Plan shall control.

     2.2. Taxes. The Participant shall, not later than the date as of which the
exercise of this Stock Option becomes a taxable event for Federal income tax
purposes, pay to the Company or make arrangements satisfactory to the
Administrator for payment of any Federal, state, and local taxes required by law
to be withheld on account of such taxable event. The Participant may elect to
have the minimum required tax withholding obligation satisfied, in whole or in
part, by (i) authorizing the Company to withhold from shares of Common Stock to
be issued, or (ii) transferring to the Company a number of shares of Common
Stock with an aggregate Fair Market Value that would satisfy the withholding
amount due.

     2.3. Notices. Notices hereunder shall be mailed or delivered to the Company
at its principal place of business and shall be mailed or delivered to the
Participant at the address on file with the Company or, in either case, at such
other address as one party may subsequently furnish to the other party in
writing. Any such notice shall be deemed to have been duly given if and when
actually received by the party to whom it is addressed, as evidenced by a
written receipt to that effect.

     2.4. No Obligation to Continue Employment.

          (a) Neither the Company nor any Subsidiary is obligated by or as a
result of the Plan or this Award Agreement to continue the Participant in
employment and neither the Plan nor this Agreement shall interfere in any way
with the right of the Company or any Subsidiary to terminate the employment of
the Participant at any time.

          (b) In the case of a Participant that is a Director, neither the Plan
nor this Award Agreement confers upon the Participant any rights with respect to
continuance as a Director.

     2.5. Governing Law. This Award Agreement and all questions arising
hereunder or in connection herewith shall be determined in accordance with the
laws of the State of Delaware, without giving effect to the principles of
conflicts of laws.

<Page>

                                   PICIS, INC.

                         DEFERRED STOCK AWARD AGREEMENT

     This Deferred Stock Award Agreement (this "Agreement") is executed as of
__________, 200__ (the "Grant Date"), by and between PICIS, Inc., a Delaware
corporation (the "Company"), and __________________ (the "Participant").

                                   WITNESSETH:

     WHEREAS the Board of Directors of the Company has established the 2005
Equity Incentive Plan of Picis, Inc. (the "Plan") for employees and directors of
the Company;

     WHEREAS, the Company anticipates that the Plan will promote the best
interests of the Company and its shareholders by providing participants who have
acquired a proprietary interest in the Company with a stronger incentive to put
forth maximum effort for the continued success and growth of the Company; and

     WHEREAS, the Company has granted to the Participant the right to
participate in the Plan in the manner and subject to the terms provided in this
Agreement and the Plan.

     NOW, THEREFORE, in consideration of the benefits that the Company will
derive in connection with the services to be rendered by the Participant, the
Company and the Participant hereby agree as follows:

          1. Provisions of Plan Control. This Agreement shall be governed by the
provisions of the Plan, the terms and conditions of which are incorporated
herein by reference. The Plan empowers the Administrator to make
interpretations, rules and regulations thereunder, and, in general, provides
that determinations of such Administrator with respect to the Plan shall be
binding upon the Participant. Unless otherwise provided herein, all capitalized
words in this Agreement shall have the meaning ascribed to them in the Plan. A
copy of the Plan has been delivered to the Participant simultaneous with the
execution of this Agreement.

          2. Deferred Stock; Number of Shares. The Participant is hereby granted
_________ shares of Deferred Stock, subject to the vesting provisions of Section
4. Each share of Deferred Stock represents the right to receive one share of the
Company's common stock (a "Share") at such future time as is set forth in this
Agreement. Notwithstanding anything contained in this Agreement to the contrary,
in the event of any stock dividend, stock split, recapitalization, merger,
consolidation, combination or exchange of shares, or the like, as a result of
which shares of any class shall be issued in respect of the outstanding Shares,
or the Shares shall be changed into the same or a different number of the same
or another class of stock, or into securities of another person, cash or other
property (not including a regular cash dividend), the amount distributed to the
Participant in exchange for the shares of Deferred Stock granted hereunder shall
be appropriately adjusted as determined by the Administrator.

<Page>

          3. Dividends and Distributions. As of each record date for the payment
of dividends on the Company's Shares, the Participant shall be granted a number
of additional shares of Deferred Stock in accordance with the Plan.

          4. Vesting Provisions. The Deferred Stock granted to the Participant
hereunder shall vest in accordance with the following vesting schedule, subject
to continued employment with the Company on each Vesting Date:

    PERCENTAGE OF
DEFERRED STOCK VESTED   VESTING DATE
---------------------   ------------

Notwithstanding the foregoing, the Deferred Stock shall become fully vested in
the event of (i) a Change in Control, or (ii) the Participant ceases to be an
employee on account of Retirement, early retirement with the consent of the
Administrator, or due to death or Disability. If a Participant cease to be
employed by the Company for any reason other than provided in the preceding
sentence, all Deferred Stock held by such Participant on the date of termination
that has not vested shall be forfeited.

          5. Prohibition Against Transfer of Deferred Stock. Except as provided
in the Plan, Deferred Stock may not be sold, assigned, conveyed, donated,
pledged, transferred or otherwise disposed of or encumbered or subjected to
execution, attachment, or similar process.

          6. Distribution of Deferred Stock. The Shares represented by the
vested Deferred Stock shall be distributed to the Participant within 30 days
after the first to occur of (a) a Change in Control, provided such Change in
Control qualifies as a "change in the ownership or effective control" or a
"change in the ownership of a substantial portion of the assets" of the Company
under Section 409A of the Code or any guidance promulgated thereunder, (b)
_________, 20__, or (c) [OTHER]. The Company shall have the right to delay the
issue or delivery of any Shares to be delivered hereunder until (i) the
completion of such registration or qualification of such Shares under federal,
state or foreign law, ruling or regulation as the Company shall deem to be
necessary or advisable, or (ii) receipt from the Participant of such documents
and information as the Company may deem necessary or appropriate in connection
with such registration or qualification or the issuance of Shares hereunder.

          7. Participant's Representations. The Participant acknowledges that he
or she shall have no interest in any fund or in any specific asset or assets of
the Company by reason of any Deferred Stock granted hereunder, nor any right to
exercise any of the rights or privileges of a shareholder with respect to any
Deferred Stock or any Shares distributable with respect to any Deferred Stock
until such Shares are so distributed. The Participant further acknowledges that
the award of the Deferred Stock, in and of itself, is not a guaranty of
continued employment by the Company, and does not interfere in any way with the
right of the Company to terminate the Participant's employment at any time.

                                        2

<Page>

          8. Taxes. The Company may require payment or reimbursement of, or may
withhold, any tax that it believes is required as a result of the grant or
distribution of the Shares, and the Company may defer making delivery with
respect to Shares payable hereunder or otherwise until arrangements satisfactory
to the Company have been made with respect to such withholding obligations. The
tax withheld in Shares will not exceed the minimum required by law in each
instance.

          9. Rights of Participant. The Deferred Stock, and any payments or
other benefits received by the Participant pursuant to the Deferred Stock, is
discretionary and shall not be deemed a part of the Participant's regular,
recurring compensation for any purpose and shall not be included in, nor have
any effect on, the determination of benefits under any other employee benefit
plan, contract or similar arrangement provided to the Participant unless
expressly so provided by such other plan, contract or arrangement, or unless the
Administrator expressly determines otherwise.

          10. Governing Law. This Agreement and all questions arising hereunder
or in connection herewith shall be determined in accordance with the laws of the
State of Delaware, without giving effect to the principles of conflicts of laws.

     IN WITNESS WHEREOF, the Company has caused these presents to be executed as
of the date and year first above written, which is the date of the granting of
the Deferred Stock evidenced hereby.

                                        PICIS, INC.

                                        By:
                                            ------------------------------------
                                            [Name, Title]

     The undersigned Participant hereby accepts the foregoing Deferred Stock and
agrees to the several terms and conditions hereof.

                                        ----------------------------------------
                                        [typed name]

                                        3

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