Document:

EX-10.4

 Exhibit 10.4 

INDEMNIFICATION AGREEMENT 

THIS INDEMNIFICATION AGREEMENT (the “Agreement”) is made and entered into as of
            , 2017 by and among, Melinta Therapeutics, Inc., f/k/a Cempra, Inc., a Delaware corporation, Cempra Pharmaceuticals, Inc., a Delaware corporation, CEM-102 Pharmaceuticals, Inc.,
a Delaware corporation, and Melinta Subsidiary Corp., f/k/a Melinta Therapeutics, Inc., a Delaware corporation (each an “Indemnitor” and collectively, the “Indemnitors”), and
             (“Indemnitee”). 
 RECITALS

 WHEREAS, effective November 3, 2017, Melinta Subsidiary Corp., f/k/a Melinta Therapeutics, Inc., merged with and into Castle
Acquisition Corp., a wholly owned subsidiary of Melinta Therapeutics, Inc., f/k/a Cempra, Inc., with Melinta Subsidiary Corp., f/k/a Melinta Therapeutics, Inc., surviving as a wholly-owned subsidiary of Melinta Therapeutics, Inc., f/k/a Cempra,
Inc.; and 
 WHEREAS, each Indemnitor desires to attract and retain highly qualified individuals, such as Indemnitee, to serve such
Indemnitor; and 
 WHEREAS, highly competent persons have become more reluctant to serve companies as officers, directors,
managers, representatives or in other capacities (each a “Representative” and collectively, the “Representatives”) unless they are provided with adequate protection through insurance or adequate
indemnification against inordinate risks of claims and actions against them arising out of their service to and activities on behalf of the corporation; and 

WHEREAS, Indemnitors and Indemnitee recognize the significant risk of claims and actions against a Representative that may arise from such
Representative’s services to and activities on behalf of Indemnitors; and 
 WHEREAS, Indemnitors and Indemnitee recognize that
Representatives of companies are being increasingly subjected to expensive and time-consuming litigation relating to, among other things, matters that traditionally would have been brought only against the company or business enterprise itself; and

 WHEREAS, Indemnitors and Indemnitee further recognize that although each Indemnitor maintains liability insurance for certain of its
Representatives, such insurance often provides for coverage of limited scope, and that competent and experienced persons are often unable or unwilling to serve as Representatives unless they are protected by comprehensive liability insurance or
indemnification; and 
 WHEREAS, Indemnitors and Indemnitee recognize that Indemnitee may be entitled to indemnification
pursuant to the General Corporation Law of the State of Delaware (“DGCL”), which expressly provides that the indemnification provisions set forth therein are not exclusive, and thereby contemplates that contracts may be
entered into between companies and their Representatives with respect to indemnification; and 

 WHEREAS, Indemnitors further recognize that uncertainties relating to liability insurance and to
indemnification have increased the difficulty of attracting and retaining highly qualified persons, such as the Indemnitee, as such persons have become more reluctant to serve companies as Representatives unless they are provided with adequate
protection through insurance or adequate indemnification against inordinate risks of claims and actions against them arising out of their service to and activities on behalf of the company; and 

WHEREAS, each Indemnitor further recognizes that the increased difficulty in attracting and retaining highly qualified persons, such as the
Indemnitee, is detrimental to the best interests of its stockholders and that such Indemnitor should act to assure such persons that there will be increased certainty of such protection in the future; and 

WHEREAS, each Indemnitor believes that it is reasonable, prudent and necessary for such Indemnitor to contractually obligate itself to
indemnify, and to advance expenses on behalf of, highly qualified persons, such as the Indemnitee, to the fullest extent permitted by applicable law so that they will serve or continue to serve such Indemnitor free from undue concern that they will
not be so indemnified; and 
 WHEREAS, each Indemnitor recognizes this Agreement is a supplement to and in furtherance of such
Indemnitor’s certificate of incorporation or bylaws, as applicable (each a “Governing Document” and collectively, the “Governing Documents”) and any resolutions adopted pursuant thereto, and shall
not be deemed a substitute therefor, nor to diminish or abrogate any rights of the Indemnitee thereunder; and 
 WHEREAS, Indemnitee does
not regard the protection available under the Governing Documents and insurance as adequate in the present circumstances, and may not be willing to serve as a Representative without adequate protection, and each Indemnitor desires Indemnitee to
serve in such capacity; and 
 WHEREAS, Indemnitee is willing to serve, continue to serve and to take on additional service for or on behalf
of each Indemnitor on the condition that he be so indemnified; and 
 WHEREAS, Indemnitee has or may from time to time obtain certain rights
to indemnification and/or insurance which Indemnitee intends to be secondary to the primary obligation of Indemnitor to indemnify Indemnitee as provided herein, with each Indemnitor’s acknowledgement and agreement to the foregoing being a
material condition to Indemnitee’s willingness to serve as a Representative of such Indemnitor; and 
 WHEREAS, in view of the
considerations set forth above, each Indemnitor desires that the Indemnitee be indemnified by such Indemnitor as set forth herein. 

 AGREEMENT 

NOW, THEREFORE, in consideration of Indemnitee’s agreement to serve as a Representative after the date hereof, the parties hereto agree
as follows. 
 1. Indemnity of Indemnitee. Each Indemnitor hereby agrees, severally but not jointly, to hold harmless and indemnify
Indemnitee to the fullest extent permitted by law, as such may be amended from time to time. In furtherance of the foregoing indemnification, and without limiting the generality thereof, each Indemnitor agrees as follows. 

(a) Proceedings Other Than Proceedings by or in the Right of Indemnitor. Indemnitee shall be entitled to the rights of indemnification
provided in this Section l(a) if, by reason of his Corporate Status (as hereinafter defined), the Indemnitee is, or is threatened to be made, a party to or participant in any Proceeding (as hereinafter defined) other than a Proceeding by or
in the right of an Indemnitor. Pursuant to this Section 1(a), Indemnitee shall be indemnified against all Expenses (as hereinafter defined), judgments, penalties, fines and amounts paid in settlement actually and reasonably incurred by
him, or on his behalf, in connection with such Proceeding or any claim, issue or matter therein, if the Indemnitee acted in good faith and in a manner the Indemnitee reasonably believed to be in or not opposed to the best interests of such
Indemnitor, and with respect to any criminal Proceeding, had no reasonable cause to believe the Indemnitee’s conduct was unlawful. 

(b) Proceedings by or in the Right of Indemnitor. Indemnitee shall be entitled to the rights of indemnification provided in this
Section 1(b) if, by reason of his Corporate Status, the Indemnitee is, or is threatened to be made, a party to or participant in any Proceeding brought by or in the right of an Indemnitor. Pursuant to this Section 1(b),
Indemnitee shall be indemnified against all Expenses actually and reasonably incurred by the Indemnitee, or on the Indemnitee’s behalf, in connection with such Proceeding if the Indemnitee acted in good faith and in a manner the Indemnitee
reasonably believed to be in or not opposed to the best interests of such Indemnitor; provided, however, if applicable law so provides, no indemnification against such Expenses shall be made in respect of any claim, issue or matter in such
Proceeding as to which Indemnitee shall have been adjudged to be liable to such Indemnitor unless and to the extent that the Court of Chancery of the State of Delaware shall determine that such indemnification may be made. 

(c) Indemnification for Expenses of a Party Who is Wholly or Partly Successful. Notwithstanding any other provision of this Agreement,
to the extent that Indemnitee is, by reason of his Corporate Status, a party to and is successful, on the merits or otherwise, in any Proceeding, he shall be indemnified to the maximum extent permitted by law, as such may be amended from time to
time, against all Expenses actually and reasonably incurred by him or on his behalf in connection therewith. If Indemnitee is not wholly successful in such Proceeding but is successful, on the merits or otherwise, as to one or more but less than all
claims, issues or matters in such Proceeding, the applicable Indemnitor shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or on his behalf in connection with each successfully resolved claim, issue or matter.
For purposes of this Section and without limitation, the termination of any claim, issue or matter in such a Proceeding by dismissal, with or without prejudice, shall be deemed to be a successful result as to such claim, issue or matter. 

2. Additional Indemnity. In addition to, and without regard to any limitations on, the indemnification provided for in
Section 1 of this Agreement, each Indemnitor shall and hereby does indemnify and hold harmless Indemnitee against all Expenses, judgments, 

 
penalties, fines and amounts paid in settlement actually and reasonably incurred by him or on his behalf if, by reason of his Corporate Status, he is, or is threatened to be made, a party to or
participant in any Proceeding (including a Proceeding by or in the right of such Indemnitor), including, without limitation, all liability arising out of the negligence or active or passive wrongdoing of Indemnitee. The only limitation that shall
exist upon such Indemnitor’s obligations pursuant to this Agreement shall be that such Indemnitor shall not be obligated to make any payment to Indemnitee that is finally determined (under the procedures, and subject to the presumptions, set
forth in Sections 6 and 7 hereof) to be unlawful. 
 3. Contribution. 

(a) Whether or not the indemnification provided in Sections 1 and 2 hereof is available, in respect of any Proceeding in which
an Indemnitor is jointly liable with Indemnitee (or would be if joined in such Proceeding), such Indemnitor shall pay, in the first instance, the entire amount of any judgment or settlement of such Proceeding without requiring Indemnitee to
contribute to such payment, and such Indemnitor hereby waives and relinquishes any right of contribution it may have against Indemnitee. No Indemnitor shall enter into any settlement of any Proceeding in which such Indemnitor is jointly liable with
Indemnitee (or would be if joined in such Proceeding) unless such settlement provides for a full and final release of all claims asserted against Indemnitee. 

(b) Without diminishing or impairing the obligations of each Indemnitor set forth in the preceding subparagraph, if, for any reason,
Indemnitee shall elect or be required to pay all or any portion of any judgment or settlement in any Proceeding in which such Indemnitor is jointly liable with Indemnitee (or would be if joined in such Proceeding), such Indemnitor shall contribute
to the amount of Expenses, judgments, fines and amounts paid in settlement actually and reasonably incurred and paid or payable by Indemnitee in proportion to the relative benefits received by such Indemnitor and all Representatives of such
Indemnitor, other than Indemnitee, who are jointly liable with Indemnitee (or would be if joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, from the transaction from which such Proceeding arose; provided, however, that
the proportion determined on the basis of relative benefit may, to the extent necessary to conform to law, be further adjusted by reference to the relative fault of such Indemnitor and all Representatives of such Indemnitor other than Indemnitee who
are jointly liable with Indemnitee (or would be if joined in such Proceeding), on the one hand, and Indemnitee, on the other hand, in connection with the events that resulted in such expenses, judgments, fines or settlement amounts, as well as any
other equitable considerations which applicable law may require to be considered. The relative fault of such Indemnitor and all Representatives of such Indemnitor, other than Indemnitee, who are jointly liable with Indemnitee (or would be if joined
in such Proceeding), on the one hand, and Indemnitee, on the other hand, shall be determined by reference to, among other things, the degree to which their actions were motivated by intent to gain personal profit or advantage, the degree to which
their liability is primary or secondary and the degree to which their conduct is active or passive. 
 (c) Each Indemnitor hereby agrees to
fully indemnify and hold Indemnitee harmless from any claims of contribution which may be brought by a Representative of such Indemnitor, other than Indemnitee, who may be jointly liable with Indemnitee. 

 (d) To the fullest extent permissible under applicable law, if the indemnification provided for
in this Agreement is unavailable to Indemnitee for any reason whatsoever, the applicable Indemnitor, in lieu of indemnifying Indemnitee, shall contribute to the amount incurred by Indemnitee, whether for judgments, fines, penalties, excise taxes,
amounts paid or to be paid in settlement and/or for Expenses, in connection with any claim relating to an indemnifiable event under this Agreement, in such proportion as is deemed fair and reasonable in light of all of the circumstances of such
Proceeding in order to reflect (i) the relative benefits received by such Indemnitor and Indemnitee as a result of the event(s) and/or transaction(s) giving cause to such Proceeding; and/or (ii) the relative fault of such Indemnitor (and
its Representatives) and Indemnitee in connection with such event(s) and/or transaction(s). 
 4. Indemnification for Expenses of a
Witness. Notwithstanding any other provision of this Agreement, to the extent that Indemnitee is, by reason of his Corporate Status, a witness, or is made (or asked) to respond to discovery requests, in any Proceeding to which Indemnitee is not
a party, he shall be indemnified against all Expenses actually and reasonably incurred by him or on his behalf in connection therewith. 

5. Advancement of Expenses. Notwithstanding any other provision of this Agreement, the applicable Indemnitor shall advance all Expenses
incurred by or on behalf of Indemnitee in connection with any Proceeding by reason of Indemnitee’s Corporate Status within twenty (20) days after the receipt by such Indemnitor of a statement or statements from Indemnitee requesting such
advance or advances from time to time, whether prior to or after final disposition of such Proceeding. Such statement or statements shall reasonably evidence the Expenses incurred by Indemnitee and shall include or be preceded or accompanied by an
undertaking by or on behalf of Indemnitee to repay any Expenses advanced if it shall ultimately be determined that Indemnitee is not entitled to be indemnified against such Expenses. Any advances and undertakings to repay pursuant to this
Section 5 shall be unsecured and interest free. 
 6. Procedures and Presumptions for Determination of Entitlement to
Indemnification. It is the intent of this Agreement to secure for Indemnitee rights of indemnity that are as favorable as may be permitted under the DGCL and public policy of the State of Delaware. Accordingly, the parties agree that the
following procedures and presumptions shall apply in the event of any question as to whether Indemnitee is entitled to indemnification under this Agreement. 

(a) To obtain indemnification under this Agreement, Indemnitee shall submit to the Secretary of the applicable Indemnitor a written request,
including therein or therewith such documentation and information as is reasonably available to Indemnitee and is reasonably necessary to determine whether and to what extent Indemnitee is entitled to indemnification (the “Supporting
Documentation”). The determination of the Indemnitee’s entitlement to indemnification shall be made no later than sixty (60) days after receipt by such Indemnitor of the written request for indemnification together with the
Supporting Documentation. The Secretary of the applicable Indemnitor shall, promptly upon receipt of such a request for indemnification, advise the Board of Directors of such Indemnitor (the “Board”) in writing that
Indemnitee has requested indemnification. Any failure of Indemnitee to provide such notice to the applicable Indemnitor, or to provide such notice in a timely fashion, shall not, 

 
however, relieve such Indemnitor of any liability or obligation which it may have to Indemnitee under this Agreement or otherwise unless and only to the extent such failure or delay materially
prejudices such Indemnitor. 
 (b) Upon written request by Indemnitee for indemnification pursuant to the first sentence of
Section 6(a) hereof, a determination, if required by applicable law, with respect to Indemnitee’s entitlement thereto shall be made in the specific case by one of the following four methods, which shall be at the election of the
Board of the applicable Indemnitor: (i) by a majority vote of the Disinterested Representatives (as defined in Section 13 below), even though less than a quorum; (ii) by a committee of Disinterested Representatives designated
by a majority vote of the Disinterested Representatives, even though less than a quorum; (iii) by Independent Counsel (as defined in Section 13 below) in a written opinion to the Board, a copy of which shall be delivered to the
Indemnitee, if (A) a quorum of the Board consisting of Disinterested Representatives is not obtainable or, even if obtainable, a majority of such Disinterested Representatives so directs; or (B) a Change of Control (as hereinafter defined)
shall have occurred and Indemnitee so requests; or (iv) if so directed by the Board, or by the members or stockholders of the applicable Indemnitor. 

(c) If the determination of entitlement to indemnification is to be made by Independent Counsel pursuant to Section 6(b) hereof,
the Independent Counsel shall be selected as provided in this Section 6(c). The Independent Counsel shall be selected by the Board of the applicable Indemnitor, but only an Independent Counsel to which Indemnitee does not reasonably
object; provided, however, that if a Change of Control shall have occurred, Indemnitee shall select such Independent Counsel, but only an Independent Counsel to which the Board does not reasonably object. Within ten (10) days after such written
notice of selection shall have been given, the non-selecting party shall deliver to the selecting party, as the case may be, a written objection to such selection; provided, however, that such objection may be asserted only on the ground that the
Independent Counsel so selected does not meet the requirements of “Independent Counsel” as defined in Section 13 of this Agreement, and the objection shall set forth with particularity the factual basis of such
assertion. Absent a proper and timely objection, the person so selected shall act as Independent Counsel. If a written objection is made and substantiated, the Independent Counsel selected may not serve as Independent Counsel unless and until such
objection is withdrawn or a court has determined that such objection is without merit. If, within twenty (20) days after submission by Indemnitee of a written request for indemnification pursuant to Section 6(a) hereof, no
Independent Counsel shall have been selected and not objected to, either the applicable Indemnitor or Indemnitee may petition the Court of Chancery of the State of Delaware or other court of competent jurisdiction for resolution of any objection
which shall have been made to the selection of Independent Counsel and/or for the appointment as Independent Counsel of a person selected by the court or by such other person as the court shall designate, and the person with respect to whom all
objections are so resolved or the person so appointed shall act as Independent Counsel under Section 6(b) hereof. The applicable Indemnitor shall pay any and all reasonable fees and expenses of Independent Counsel incurred by such
Independent Counsel in connection with acting pursuant to Section 6(b) hereof, and such Indemnitor shall pay all reasonable fees and expenses incident to the procedures of this Section 6(c), regardless of the manner in which
such Independent Counsel was selected or appointed. 

 (d) For purposes of this Section 6, “Change in Control”
means a change in control of an Indemnitor of a nature that would be required to be reported in response to Item 6(e) of Schedule 14A of Regulation 14A promulgated under the Securities Exchange Act of 1934, as amended (the “Exchange
Act”), whether or not the corporation is then subject to such reporting requirement; provided that, without limitation, such a change in control shall be deemed to have occurred if (i) any “person” (as such term is used
in Sections 13(d) and 14(d) of the Exchange Act) is or becomes the “beneficial owner” (as defined in Rule l3d-3 under the Exchange Act), directly or indirectly, of securities of such Indemnitor
representing 25% or more of the combined voting power of such Indemnitor’s then outstanding securities without the prior approval of at least a majority of the members of the Board, immediately prior to such acquisition; (ii) such
Indemnitor is a party to a merger, consolidation, sale of assets or other reorganization, or a proxy contest, as a consequence of which members of the Board in office immediately prior to such transaction or event constitute less than a majority of
the Board thereafter; or (iii) during any period of two consecutive years, individuals who at the beginning of such period constituted the Board (including for this purpose any new member whose election or nomination for election by such
Indemnitor’s stockholders was approved by a vote of at least a majority of the Board then still in office who were members of the Board at the beginning of such period) cease for any reason to constitute at least a majority of the Board. 

(e) In making a determination with respect to entitlement to indemnification hereunder, the person or persons or entity making such
determination shall presume that Indemnitee is entitled to indemnification under this Agreement. Anyone seeking to overcome this presumption shall have the burden of proof and the burden of persuasion by clear and convincing evidence. Neither the
failure of an Indemnitor (including by its officers, managers, Board or Independent Counsel) to have made a determination prior to the commencement of any action pursuant to this Agreement that indemnification is proper in the circumstances because
Indemnitee has met the applicable standard of conduct, nor an actual determination by such Indemnitor (including by its officers, managers, Board or Independent Counsel) that Indemnitee has not met such applicable standard of conduct, shall be a
defense to the action or create a presumption that Indemnitee has not met the applicable standard of conduct. 
 (f) Indemnitee shall be
deemed to have acted in good faith if Indemnitee’s action is based on the records or books of account of the Enterprise (as defined in Section 13 below), including financial statements, or on information supplied to Indemnitee by
the officers of the Enterprise in the course of their duties, or on the advice of legal counsel for the Enterprise or on information or records given or reports made to the Enterprise by an independent certified public accountant or by an appraiser
or other expert selected with reasonable care by the Enterprise. In addition, the knowledge and/or actions, or failure to act, of any Representative of the Enterprise shall not be imputed to Indemnitee for purposes of determining the right to
indemnification under this Agreement. Whether or not the foregoing provisions of this Section 6(f) are satisfied, it shall in any event be presumed that Indemnitee has at all times acted in good faith and in a manner he reasonably
believed to be in or not opposed to the best interests of the applicable Indemnitor. Anyone seeking to overcome this presumption shall have the burden of proof and the burden of persuasion by clear and convincing evidence. 

 (g) If the person, persons or entity empowered or selected under Section 6 to
determine whether Indemnitee is entitled to indemnification shall not have made a determination within sixty (60) days after receipt by an Indemnitor of the request therefor, the requisite determination of entitlement to indemnification shall
be deemed to have been made and Indemnitee shall be entitled to such indemnification absent (i) a misstatement by Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially
misleading, in connection with the request for indemnification, or (ii) a prohibition of such indemnification under applicable law; provided, however, that such 60-day period may be extended for a reasonable time, not to exceed an additional
thirty (30) days, if the person, persons or entity making such determination with respect to entitlement to indemnification in good faith requires such additional time to obtain or evaluate documentation and/or information relating thereto; and
provided, further, that the foregoing provisions of this Section 6(g) shall not apply if the determination of entitlement to indemnification is to be made by the stockholders pursuant to Section 6(b) of this Agreement and if
(A) within fifteen (15) days after receipt such Indemnitor of the request for such determination, the Board or the Disinterested Representatives, if appropriate, resolve to submit such determination to the stockholders for their
consideration at an annual meeting thereof to be held within seventy-five (75) days after such receipt and such determination is made thereat, or (B) a special meeting of stockholders is called within fifteen (15) days after such
receipt for the purpose of making such determination, such meeting is held for such purpose within sixty (60) days after having been so called and such determination is made thereat. 

(h) Indemnitee shall cooperate with the person, persons or entity making such determination with respect to Indemnitee’s entitlement to
indemnification, including providing to such person, persons or entity upon reasonable advance request any documentation or information which is not privileged or otherwise protected from disclosure and which is reasonably available to Indemnitee
and reasonably necessary to such determination. Any Independent Counsel, member of the Board or stockholders of an Indemnitor shall act reasonably and in good faith in making a determination regarding the Indemnitee’s entitlement to
indemnification under this Agreement. Any costs or expenses (including attorneys’ fees and disbursements) incurred by Indemnitee in so cooperating with the person, persons or entity making such determination shall be borne by such Indemnitor
(irrespective of the determination as to Indemnitee’s entitlement to indemnification) and such Indemnitor hereby indemnifies and agrees to hold Indemnitee harmless therefrom. 

(i) Each Indemnitor acknowledges that a settlement or other disposition short of final judgment may be successful if it permits a party to
avoid expense, delay, distraction, disruption and uncertainty. In the event that any Proceeding to which Indemnitee is a party is resolved in any manner other than by adverse judgment against Indemnitee (including, without limitation, settlement of
such Proceeding with or without payment of money or other consideration) it shall be presumed that Indemnitee has been successful on the merits or otherwise in such Proceeding. Anyone seeking to overcome this presumption shall have the burden of
proof and the burden of persuasion by clear and convincing evidence. 

 (j) The termination of any Proceeding or of any claim, issue or matter therein, by judgment,
order, settlement or conviction, or upon a plea of nolo contendere or its equivalent, shall not (except as otherwise expressly provided in this Agreement) of itself adversely affect the right of Indemnitee to indemnification or create a
presumption that Indemnitee did not act in good faith and in a manner which he reasonably believed to be in or not opposed to the best interests of an Indemnitor or, with respect to any criminal Proceeding, that Indemnitee had reasonable cause to
believe that his conduct was unlawful. 
 7. Remedies of Indemnitee. 

(a) In the event that (i) a determination is made pursuant to Section 6 of this Agreement that Indemnitee is not entitled to
indemnification under this Agreement, (ii) advancement of Expenses is not timely made pursuant to Section 5 of this Agreement, (iii) no determination of entitlement to indemnification is made pursuant to
Section 6(b) of this Agreement within ninety (90) days after receipt by the an Indemnitor of the request for indemnification, (iv) payment of indemnification is not made pursuant to this Agreement within five (5) days
after receipt by an Indemnitor of a written request therefor or (v) payment of indemnification is not made within five (5) days after a determination has been made that Indemnitee is entitled to indemnification or such determination is
deemed to have been made pursuant to Section 6 of this Agreement, Indemnitee shall be entitled to an adjudication of Indemnitee’s entitlement to such indemnification either (A) in an appropriate court of the State of Delaware,
or in any other court of competent jurisdiction, or (B) in an arbitration to be conducted by a single arbitrator pursuant to the rules of the American Arbitration Association. Indemnitee shall commence such proceeding seeking an adjudication
within 180 days following the date on which Indemnitee first has the right to commence such proceeding pursuant to this Section 7(a). No Indemnitor shall oppose Indemnitee’s right to seek any such adjudication. 

(b) In the event that a determination shall have been made pursuant to Section 6(b) of this Agreement that Indemnitee is not
entitled to indemnification, any judicial proceeding or arbitration commenced pursuant to this Section 7 shall be conducted in all respects as de novo, and Indemnitee shall not be prejudiced by reason of the adverse determination
under Section 6(b). 
 (c) If a determination shall have been made pursuant to Section 6(b) of this Agreement that
Indemnitee is entitled to indemnification, the applicable Indemnitor shall be bound by such determination in any judicial proceeding commenced pursuant to this Section 7, absent (i) a misstatement by Indemnitee of a material fact,
or an omission of a material fact necessary to make Indemnitee’s misstatement not materially misleading in connection with the application for indemnification, or (ii) a prohibition of such indemnification under applicable law. 

(d) In the event that Indemnitee, pursuant to this Section 7, seeks a judicial adjudication of his rights under, or to recover
damages for breach of, this Agreement, or to recover under any directors’ and officers’ liability insurance policies maintained by an Indemnitor, such Indemnitor shall pay on his behalf, in advance, any and all expenses (of the types
described in the definition of Expenses in Section 13 of this Agreement) actually and reasonably incurred by him in such judicial adjudication, regardless of whether Indemnitee ultimately is determined to be entitled to such
indemnification, advancement of expenses or insurance recovery. 

 (e) Each Indemnitor shall be precluded from asserting in any judicial proceeding commenced
pursuant to this Section 7 that the procedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate in any such court that such Indemnitor is bound by all the provisions of this Agreement. Each
Indemnitor shall indemnify Indemnitee against any and all Expenses and, if requested by Indemnitee, shall (within ten (10) days after receipt by such Indemnitor of a written request therefor) advance, to the extent not prohibited by law, such
expenses to Indemnitee, which are incurred by Indemnitee in connection with any action brought by Indemnitee for indemnification or advance of Expenses from such Indemnitor under this Agreement or under any directors’ and officers’
liability insurance policies maintained by such Indemnitor, regardless of whether Indemnitee ultimately is determined to be entitled to such indemnification, advancement of Expenses or insurance recovery, as the case may be. 

(f) Notwithstanding anything in this Agreement to the contrary, no determination as to entitlement to indemnification under this Agreement
shall be required to be made prior to the final disposition of the Proceeding 
 8. Non-Exclusivity; Survival of Rights; Insurance;
Primacy of Indemnification; Subrogation; Several Obligations. 
 (a) The rights of indemnification as provided by this Agreement shall
not be deemed exclusive of any other rights to which Indemnitee may at any time be entitled under applicable law, the Governing Documents, any agreement, a vote of stockholders, a resolution of the Board or otherwise. No amendment, alteration or
repeal of this Agreement or of any provision hereof shall limit or restrict any right of Indemnitee under this Agreement in respect of any action taken or omitted by such Indemnitee in his Corporate Status prior to such amendment, alteration or
repeal. To the extent that a change in the DGCL, whether by statute or judicial decision, permits greater indemnification than would be afforded currently under the Governing Documents and this Agreement, it is the intent of the parties hereto that
Indemnitee shall enjoy by this Agreement the greater benefits so afforded by such change. No right or remedy herein conferred is intended to be exclusive of any other right or remedy, and every other right and remedy shall be cumulative and in
addition to every other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or
employment of any other right or remedy. 
 (b) To the extent that an Indemnitor maintains an insurance policy or policies providing
liability insurance for directors, managers, officers, employees, or agents or fiduciaries of such Indemnitor or of any other Enterprise that such person serves at the request of such Indemnitor, Indemnitee shall be covered by such policy or
policies in accordance with its or their terms to the maximum extent of the coverage available for any director, manager, officer, employee, agent or fiduciary under such policy or policies. If, at the time of the receipt of a notice of a claim
pursuant to the terms hereof, an Indemnitor has director and officer liability insurance in effect, such Indemnitor shall give prompt notice of the commencement of such proceeding to the insurers in accordance with the procedures set forth in the
respective policies. The applicable Indemnitor shall thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of the Indemnitee, all amounts payable as a result of such proceeding in accordance with the terms of
such policies. 

 (c) Each Indemnitor hereby acknowledges that Indemnitee has or may from time to time obtain
certain rights to indemnification, advancement of expenses and/or insurance provided by one or more third party entities or its affiliates in connection with his or her service on the Board of Directors at the behest of such third party entity
(collectively the “Third Party Indemnitors”). Each Indemnitor hereby agrees (i) that it is the indemnitor of first resort (i.e., its obligations to Indemnitee are primary and any obligation of the Third Party Indemnitors
to advance expenses or to provide indemnification for the same expenses or liabilities incurred by Indemnitee are secondary), (ii) that it shall be required to advance the full amount of expenses incurred by Indemnitee and shall be liable for
the full amount of all Expenses, judgments, penalties, fines and amounts paid in settlement to the extent legally permitted and as required by the Governing Documents of such Indemnitor (or any agreement between such Indemnitor and Indemnitee),
without regard to any rights Indemnitee may have against the Third Party Indemnitors, and, (iii) that it irrevocably waives, relinquishes and releases the Third Party Indemnitors from any and all claims against the Third Party Indemnitors for
contribution, subrogation or any other recovery of any kind in respect thereof. Each Indemnitor further agrees that no advancement or payment by the Third Party Indemnitors on behalf of Indemnitee with respect to any claim for which Indemnitee has
sought indemnification from such Indemnitor shall affect the foregoing and the Third Party Indemnitors shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of
Indemnitee against such Indemnitor. Each Indemnitor and Indemnitee agree that each Third Party Indemnitor is an express third party beneficiary of the terms hereof. 

(d) Except as set forth in paragraph (c) above, in the event of any payment under this Agreement, each Indemnitor shall be subrogated to
the extent of such payment to all of the rights of recovery the Indemnitee may have against an opposing party to the Proceeding giving rise to the payment to the Indemnitee under this Agreement, and the Indemnitee shall execute all papers required
and take all action necessary to secure such rights, including execution of such documents as are necessary to enable such Indemnitor to bring suit to enforce such rights. 

(e) Except as set forth in paragraph (c) above, no Indemnitor shall be liable under this Agreement to make any payment of amounts
otherwise indemnifiable hereunder if and to the extent that Indemnitee has otherwise actually received such payment under any insurance policy, contract, agreement or otherwise. 

(f) Except as set forth in paragraph (c) above, each Indemnitor’s obligation to indemnify or advance Expenses hereunder to
Indemnitee who is or was serving at the request of such Indemnitor as a Representative of any other Enterprise shall be reduced by any amount Indemnitee has actually received as indemnification or advancement of expenses from such other Enterprise.

 (g) The indemnification obligations of each Indemnitor hereunder, shall be limited to matters related to the service of the Indemnitee
as a Representative of such Indemnitor. Notwithstanding anything to the contrary contained herein, no Indemnitor shall 

 
have any obligation to indemnify the Indemnitee for losses related to a Proceeding arising from the Indemnitee’s service as a Representative of another Indemnitor, except to the extent that
such Proceeding also relates to the Indemnitee’s service as a Representative for such Indemnitor. To the extent that the Indemnitee is entitled to indemnification from more than one Indemnitor, no Indemnitor shall be liable for indemnification
obligations in excess of such Indemnitor’s proportionate share of Expenses, judgments, penalties, fines and amounts paid as a result of such Proceeding. 

9. Exception to Right of Indemnification. Notwithstanding any provision in this Agreement, no Indemnitor shall be obligated under this
Agreement to make any indemnity in connection with any claim made against Indemnitee: 
 (a) for which payment has actually been made to or
on behalf of Indemnitee under any insurance policy or other indemnity provision, except (i) with respect to any excess beyond the amount paid under any insurance policy or other indemnity provision, or (ii) as set forth in paragraph 8(c)
above; 
 (b) for an accounting of profits made from the purchase and sale (or sale and purchase) by Indemnitee of securities of such
Indemnitor within the meaning of Section 16(b) of the Exchange Act, or similar provisions of state statutory law or common law; or 

(c) in connection with any Proceeding (or any part of any Proceeding) initiated by Indemnitee, including any Proceeding (or any part of any
Proceeding) initiated by Indemnitee against such Indemnitor or its Representatives, unless (i) the Board of such Indemnitor authorized the Proceeding (or any part of any Proceeding) prior to its initiation, or (ii) such Indemnitor provides
the indemnification, in its sole discretion, pursuant to the powers vested in such Indemnitor under applicable law. 
 10. Duration of
Agreement. All agreements and obligations of each Indemnitor contained herein shall continue during and apply to the period Indemnitee is or was a Representative of such Indemnitor (or is or was serving at the request of such Indemnitor as a
Representative of such Indemnitor or another Enterprise) and shall continue thereafter so long as Indemnitee shall be subject to any Proceeding (or any proceeding commenced under Section 7 hereof) by reason of his Corporate Status,
whether or not he is acting or serving in any such capacity at the time any liability or expense is incurred for which indemnification can be provided under this Agreement. This Agreement shall be binding upon and inure to the benefit of and be
enforceable by the parties hereto and their respective successors (including any direct or indirect successor by purchase, merger, consolidation or otherwise to all or substantially all of the business or assets of such Indemnitor), assigns,
spouses, heirs, executors and personal and legal representatives. 
 11. Security. To the extent requested by Indemnitee and approved
by the Board of an Indemnitor, such Indemnitor may at any time and from time to time provide security to Indemnitee for such Indemnitor’s obligations hereunder through an irrevocable bank line of credit, funded trust or other collateral. Any
such security, once provided to Indemnitee, may not be revoked or released without the prior written consent of the Indemnitee. 

 12. Enforcement. 

(a) Each Indemnitor expressly confirms and agrees that it has entered into this Agreement and assumes the obligations imposed on it hereby in
order to induce Indemnitee to serve as a Representative of such Indemnitor, and each Indemnitor acknowledges that Indemnitee is relying upon this Agreement in serving as a Representative of such Indemnitor. 

(b) This Agreement constitutes the entire agreement between the parties hereto with respect to the subject matter hereof and supersedes all
prior agreements and understandings, oral, written and implied, between the parties hereto with respect to the subject matter hereof. 
 13.
Definitions. The following terms have the following definitions for purposes of this Agreement. 
 (a) “Corporate
Status” describes the status of a person who is or was a representative, director, manager, officer, employee, agent or fiduciary of the applicable Indemnitor or of any other Enterprise that such person is or was serving at the express
written request of such Indemnitor. 
 (b) “Disinterested Representative” means a member of the Board of an
Indemnitor who is not and was not a party to the Proceeding in respect of which indemnification is sought by Indemnitee. 
 (c)
“Enterprise” shall mean an Indemnitor and any other corporation, partnership, joint venture, trust, employee benefit plan or other enterprise that Indemnitee is or was serving at the express written request of such Indemnitor
as a representative, director, manager, officer, employee, agent or fiduciary. 
 (d) “Expenses” shall include all
reasonable attorneys’ fees, retainers, court costs, transcript costs, fees of experts, witness fees, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees and all other disbursements
or expenses of the types customarily incurred in connection with prosecuting, defending, preparing to prosecute or defend, investigating, participating, or being or preparing to be a witness in a Proceeding. Expenses also shall include Expenses
incurred in connection with any appeal resulting from any Proceeding, including without limitation the premium, security for, and other costs relating to any cost bond, supersede as bond, or other appeal bond or its equivalent. Expenses, however,
shall not include amounts paid in settlement by Indemnitee or the amount of judgments or fines against Indemnitee. 
 (e)
“Independent Counsel” means a law firm, or a member of a law firm, that is experienced in matters of corporation law and neither presently is, nor in the past five years has been, retained to represent: (i) the
Indemnitors or Indemnitee in any matter material to either such party (other than with respect to matters concerning Indemnitee under this Agreement, or of other indemnitees under similar indemnification agreements), or (ii) any other party to
the Proceeding giving rise to a claim for indemnification hereunder. Notwithstanding the foregoing, the term “Independent Counsel” shall not include any person who, under the 

 
applicable standards of professional conduct then prevailing, would have a conflict of interest in representing either an Indemnitor or Indemnitee in an action to determine Indemnitee’s
rights under this Agreement. Each Indemnitor agrees to pay the reasonable fees of the Independent Counsel referred to above and to fully indemnify such counsel against any and all Expenses, claims, liabilities and damages arising out of or relating
to this Agreement or its engagement pursuant hereto. 
 (f) “Proceeding” includes any threatened, pending or
completed action, suit, arbitration, alternate dispute resolution mechanism, investigation, inquiry, administrative hearing or any other actual, threatened or completed proceeding, whether brought by or in the right of an Indemnitor or otherwise and
whether civil, criminal, administrative or investigative, in which Indemnitee was, is or will be involved as a party or otherwise, by reason of the fact that Indemnitee is or was a Representative of such Indemnitor, by reason of any action taken by
him or of any inaction on his part while acting as a Representative of such Indemnitor, or by reason of the fact that he is or was serving at the request of such Indemnitor as a Representative of another Enterprise; in each case whether or not he is
acting or serving in any such capacity at the time any liability or expense is incurred for which indemnification can be provided under this Agreement; including one pending on or before the date of this Agreement, but excluding one initiated by an
Indemnitee pursuant to Section 7 of this Agreement to enforce his rights under this Agreement. 
 14. Severability. The
invalidity of unenforceability of any provision hereof shall in no way affect the validity or enforceability of any other provision. Without limiting the generality of the foregoing, this Agreement is intended to confer upon Indemnitee
indemnification rights to the fullest extent permitted by applicable laws. In the event any provision hereof conflicts with any applicable law, such provision shall be deemed modified, consistent with the aforementioned intent, to the extent
necessary to resolve such conflict. 
 15. Modification and Waiver. No supplement, modification, termination or amendment of this
Agreement shall be binding unless executed in writing by all of the parties hereto. No waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any other provisions hereof (whether or not similar) nor shall
such waiver constitute a continuing waiver. 
 16. Notice By Indemnitee. Indemnitee agrees promptly to notify each Indemnitor in
writing upon being served with or otherwise receiving any summons, citation, subpoena, complaint, indictment, information or other document relating to any Proceeding or matter which may be subject to indemnification covered hereunder. The failure
to so notify the Indemnitors shall not relieve the applicable Indemnitor of any obligation which it may have to Indemnitee under this Agreement or otherwise unless and only to the extent that such failure or delay materially prejudices such
Indemnitor. 
 17. Notices. All notices and other communications given or made pursuant to this Agreement shall be in writing and
shall be deemed effectively given: (1) upon personal delivery to the party to be notified; (2) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient, and if not so confirmed, then on the
next business day; (3) five (5) days after having been sent by registered or certified mail, return 

 
receipt requested, postage prepaid; or (4) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt.
All communications shall be sent: 
  

	 	(a)	to Indemnitee at the address set forth below Indemnitee’s signature hereto; or 

  

	 	(b)	to Indemnitor at: 

  

	 	  	Melinta Therapeutics, Inc. 

	 	  	300 George Street 

	 	  	Suite 301 

	 	  	New Haven, Connecticut 06511 

	 	  	Attn: Daniel Wechsler 

	 	  	Telephone: (312) 767-0291 

 or to such other address as may have been furnished to Indemnitee by an
Indemnitor or to an Indemnitor by Indemnitee, as the case may be. 
 18. Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same Agreement. This Agreement may also be executed and delivered by facsimile signature and in two or more counterparts, each of which
shall be deemed an original, but all of which together shall constitute one and the same instrument. 
 19. Headings. The headings of
the paragraphs of this Agreement are inserted for convenience only and shall not be deemed to constitute part of this Agreement or to affect the construction thereof. 

20. Governing Law and Consent to Jurisdiction. This Agreement and the legal relations among the parties shall be governed by, and
construed and enforced in accordance with, the laws of the State of Delaware, without regard to its conflict of laws rules. Each Indemnitor and Indemnitee hereby irrevocably and unconditionally (a) agrees that any action or proceeding arising
out of or in connection with this Agreement shall be brought only in the Chancery Court of the State of Delaware (the “Delaware Court”), and not in any other state or federal court in the United States of America or any court
in any other country, (b) consents to submit to the exclusive jurisdiction of the Delaware Court for purposes of any action or proceeding arising out of or in connection with this Agreement, (c) waives any objection to the laying of venue
of any such action or proceeding in the Delaware Court, and (d) waives and agrees not to plead or to make, any claim that any such action or proceeding brought in the Delaware Court has been brought in an improper or inconvenient forum. 

[The next page is the signature page.] 

 IN WITNESS WHEREOF, the parties hereto have executed this Indemnification Agreement on and as of
the day and year first above written. 
  

							
	INDEMNITORS:	 		 	MELINTA THERAPEUTICS, INC.,
		 		 	F/K/A CEMPRA, INC.
				
		 		 	By:	 	  

		 		 		 	Daniel Wechsler
		 		 		 	President and CEO
			
		 		 	MELINTA SUBSIDIARY CORP.,
		 		 	F/K/A MELINTA THERAPEUTICS, INC.
				
		 		 	By:	 	  

		 		 		 	Daniel Wechsler
		 		 		 	President and CEO
			
		 		 	CEMPRA PHARMACEUTICALS, INC.
				
		 		 	By:	 	  

		 		 		 	Daniel Wechsler
		 		 		 	President and CEO
			
		 		 	CEM-102 PHARMACEUTICALS, INC.
				
		 		 	By:	 	  

		 		 		 	Daniel Wechsler
		 		 		 	President and CEO
			
	 INDEMNITEE:
  
	 		 	  

		 		 	Name:	 	  

			
		 		 	Address:EX-10.5

 Exhibit 10.5 

Execution Version 

EMPLOYMENT AGREEMENT 
 This
EMPLOYMENT AGREEMENT (this “Agreement”) is made and entered into this this 30th day of October 2017, by and between Melinta Therapeutics, Inc., a Delaware corporation (the “Company”), and Daniel
Mark Wechsler (“Executive”). Upon the closing of the transactions contemplated by that certain Agreement and Plan of Merger and Reorganization (the “Acquisition Agreement”), dated August 8, 2017,
by and among Cempra, Inc. (“Cempra”), a Delaware corporation, Castle Acquisition Corp., a Delaware corporation and the Company, this Agreement shall be assumed by Cempra and all references herein to the Company shall refer to
Cempra, which shall be renamed “Melinta Therapeutics, Inc.” 
 W I T N E S S
E T H : 
 WHEREAS, the Company desires to employ Executive and to enter into this Agreement embodying the terms of
such employment, and Executive desires to enter into this Agreement and to accept such employment, subject to the terms and provisions of this Agreement. 

NOW, THEREFORE, in consideration of the promises and mutual covenants contained herein and for other good and valuable consideration, the
receipt and sufficiency of which are mutually acknowledged, the Company and Executive hereby agree as follows: 
 Section 1.
Definitions. 
 Terms used herein with initial capitalization not otherwise defined are defined in Appendix A to this
Agreement. 
 Section 2. Acceptance and Term. 

The Company agrees to employ Executive, and Executive agrees to serve the Company, on the terms and conditions set forth herein for a term
(such period of employment, the “Term”) commencing immediately following the closing of the transactions contemplated by the Acquisition Agreement (the “Commencement Date”) and ending upon the
termination of Executive’s employment pursuant to Section 8 below. 
 Section 3. Position, Duties, and Responsibilities;
Place of Performance. 
 (a) Position, Duties, and Responsibilities. During the Term, Executive shall be employed and serve as the
President and Chief Executive Officer of the Company (together with such other position or positions consistent with Executive’s titles and positions as President and Chief Executive Officer of the Company as the Board shall specify from time
to time), reporting directly to the Board, and shall have such duties and responsibilities commensurate with such titles and positions as the most senior officer of the Company. Effective as of the Commencement Date, Executive shall be appointed as
a member of the Board, and thereafter, for so long as Executive is the Chief Executive Officer of the Company, the Board shall nominate Executive for election to the Board at each annual meeting of the stockholders where his term of office as a
director would expire; provided, further, that the foregoing shall not be required to the extent prohibited by legal or regulatory requirements and Executive is treated in the same manner as similarly situated directors. Executive also
agrees to serve as an officer and/or director of any other member of the Company Group, in each case without additional compensation. 

 (b) Performance. Executive shall devote Executive’s full business time, attention,
skill, and best efforts to the performance of Executive’s duties under this Agreement and shall not engage in any other business or occupation during the Term, including, without limitation, any activity that (x) conflicts with the
interests of the Company or any other member of the Company Group, (y) interferes with the proper and efficient performance of Executive’s duties for the Company, or (z) interferes with Executive’s exercise of judgment in the
Company’s best interests. Notwithstanding the foregoing, nothing herein shall preclude Executive from (i) serving, with the prior written consent of the Board, as a member of the boards of directors or advisory boards (or their equivalents
in the case of a non-corporate entity) of non-competing businesses and charitable organizations, (ii) engaging in charitable activities and community affairs, and
(iii) managing Executive’s personal investments and affairs; provided, however, that the activities set out in clauses (i), (ii), and (iii) shall be limited by Executive so as not to materially interfere, individually or
in the aggregate, with the performance of Executive’s duties and responsibilities hereunder. 
 (c) Place of Performance.
Executive acknowledges and agrees that, during the Term, he shall be required to spend sufficient time among each of the Company offices and other business locations to effectively perform his duties and responsibilities, and that frequent business
travel may be necessary. Executive shall not be required to relocate his residence in connection with his employment under this Agreement. 

Section 4. Compensation. 

During the Term, Executive shall be entitled to the following compensation: 

(a) Base Salary. Executive shall be paid an annualized Base Salary, payable in accordance with the regular payroll practices of the
Company, of not less than $550,000, with increases, if any, as may be approved in writing by the Compensation Committee; provided, however, that the foregoing shall not preclude the Compensation Committee from reducing Executive’s Base
salary as part of an across-the-board reduction applicable in like proportions to all similarly situated executives of the Company. 

(b) Annual Bonus. Executive shall be eligible for an annual incentive bonus award determined by the Compensation Committee
in respect of each fiscal year during the Term (the “Annual Bonus”). The target Annual Bonus for each fiscal year shall be 60% of Base Salary (“Target Annual Bonus”) and the maximum Annual Bonus
shall not be less than 150% of Base Salary, with the actual Annual Bonus payable being based upon the level of achievement of annual Company and specific individual performance objectives for such fiscal year, as determined by the Compensation
Committee and communicated to Executive. Executive’s Annual Bonus for 2017 shall be prorated based on the number of days worked in that year at not less than the target amount. The Annual Bonus shall be paid to Executive at the same time as
annual bonuses are generally payable to other senior executives of the Company subject to Executive’s continuous employment through the payment date except as otherwise provided for in this Agreement. 

  
 2 

 (c) Sign-On Equity Grants. On the Commencement
Date, the Company shall grant to Executive: 
 (i) A stock option to purchase a number of shares of the Company equal to 2.25% of the fully
diluted equity capitalization of the Company as of the Commencement Date (the “Initial Stock Option Grant”), at an exercise price equal to the closing price per share of common stock on the Nasdaq on the grant date.
Subject to Executive’s continued employment with the Company through each applicable vesting date and subject to Section 8(d)(vi) hereof, twenty-five percent (25%) of the Initial Stock Option Grant will vest and become exercisable on the
first anniversary of the Commencement Date and the remainder will vest and become exercisable in substantially equal monthly installments during the three (3) year period commencing on the first anniversary of the Commencement Date, and will be
granted in the form of stock option award agreement provided to Executive with this Agreement; and 
 (ii) A restricted stock unit award for
a number of shares of the Company equal to 0.75% of the fully diluted equity capitalization of the Company as of the Commencement Date (the “Initial Restricted Stock Unit Grant”). Subject to Executive’s continued
employment with the Company through each applicable vesting date and subject to Section 8(d)(vi) hereof, twenty-five percent (25%) of the Initial Restricted Stock Unit Grant will vest and be settled on the first anniversary of the Commencement
Date and the remainder will vest and be settled in substantially equal monthly installments during the three (3) year period commencing on the first anniversary of the Commencement Date, and will be granted in the form of restricted stock unit
award agreement provided to Executive with this Agreement. The Initial Restricted Stock Unit Grant will participate in any dividends paid to stockholders of the Company during such vesting period; provided, that dividends on shares underlying
unvested restricted stock units shall be subject to the same vesting requirements as the underlying shares on which such dividends are paid and payment deferred and paid within ten (10) days after such restricted stock units become vested (and
will be forfeited to the extent unvested restricted stock are forfeited). 
 (d) Change in Control. Subject to Section 8(d)(vi)
hereof, if either of the Initial Stock Option Grant or the Initial Restricted Stock Unit Grant is not expressly assumed in a Change in Control, such award will fully vest upon such Change in Control (and participate fully with other stockholders in
such Change in Control). 
 (e) Annual Equity/LTI Grants. Executive shall be eligible for annual equity (or other long-term incentive)
grants, commencing with grants made to senior executives in fiscal year 2019, in such forms, amounts and terms as shall be determined by the Compensation Committee in its sole discretion. 

(f) Inducement Grant. The Initial Stock Option Grant and Initial Restricted Stock Unit Grant will be granted under a non-stockholder approved arrangement outside of any Company equity plan pursuant to the Nasdaq’s “inducement exception.” Executive agrees that the granting of the Initial Stock Option Grant and
Initial Restricted Stock Unit Grant is an inducement material to Executive’s decision to enter into this Agreement and accept employment with the Company. 

  
 3 

 Section 5. Employee Benefits. 

During the Term, Executive shall be entitled to participate in health, insurance, retirement, and other benefits provided generally to
similarly situated executives of the Company. Executive shall also be entitled to the same number of holidays and sick days, as well as any other benefits, in each case as are generally allowed to similarly situated executive of the Company in
accordance with the Company policy as in effect from time to time. Executive shall be entitled to not less than four (4) weeks of vacation per year. Nothing contained herein shall be construed to limit the Company’s ability to amend,
suspend, or terminate any employee benefit plan or policy at any time without providing Executive notice, and the right to do so is expressly reserved. 

Section 6. Key-Man Insurance. 

At any time during the Term, the Company shall have the right to insure the life of Executive for the sole benefit of the Company, in such
amounts, and with such terms, as it may determine. All premiums payable thereon shall be the obligation of the Company. Executive shall have no interest in any such policy, but agrees to cooperate with the Company in procuring such insurance by
submitting to physical examinations, supplying all information required by the insurance company, and executing all necessary documents, provided that no financial obligation is imposed on Executive by any such documents. The Company shall maintain,
and instruct such insurance company and its agents to maintain, any such physical examination and other application submissions in strictest confidence. 

Section 7. Reimbursement of Business Expenses. 

During the Term, the Company shall pay (or promptly reimburse Executive) for documented, out-of-pocket expenses reasonably incurred by Executive in the course of performing Executive’s duties and responsibilities hereunder, which are consistent with the Company’s policies in effect from
time to time with respect to business expenses, subject to the Company’s requirements with respect to reporting of such expenses. The Company will pay Executive’s professional expenses incurred to negotiate and prepare this Agreement and
all other related agreements hereunder, in an amount not to exceed $15,000. 
 Section 8. Termination of Employment. 

(a) General. The Term shall terminate earlier than as provided in Section 2 hereof upon the earliest to occur of
(i) Executive’s death, (ii) a termination by reason of a Disability, (iii) a termination by the Company with or without Cause, and (iv) a termination by Executive with or without Good Reason. Upon any termination of
Executive’s employment for any reason, except as may otherwise be requested by the Company in writing and agreed upon in writing by Executive, Executive shall be deemed to have resigned from any and all directorships, committee memberships, and
any other positions Executive holds with the Company or any other member of the Company Group and hereby agrees to execute any documents that the Company (or any member of the Company Group) determines necessary to

  
 4 

 
effectuate such resignations. Notwithstanding anything herein to the contrary, the payment (or commencement of a series of payments) hereunder of any “nonqualified deferred
compensation” (within the meaning of Section 409A of the Code) upon a termination of employment shall be delayed until such time as Executive has also undergone a “separation from service” as defined in Treas. Reg. 1.409A-1(h), at which time such nonqualified deferred compensation (calculated as of the date of Executive’s termination of employment hereunder) shall be paid (or commence to be paid) to Executive on
the schedule set forth in this Section 8 as if Executive had undergone such termination of employment (under the same circumstances) on the date of Executive’s ultimate “separation from service.” 

(b) Termination Due to Death or Disability. Executive’s employment shall terminate automatically upon Executive’s death. The
Company may terminate Executive’s employment immediately upon the occurrence of a Disability, such termination to be effective upon Executive’s receipt of written notice of such termination. Upon Executive’s death or in the event that
Executive’s employment is terminated due to Executive’s Disability, Executive or Executive’s estate or Executive’s beneficiaries, as the case may be, shall be entitled to: 

(i) The Accrued Obligations; 

(ii) Any unpaid Annual Bonus in respect of any completed fiscal year that has ended prior to the date of such termination, which amount shall
be paid at such time annual bonuses are paid to other senior executives of the Company, but in no event later than the date that is two and one-half (2 1⁄2) months following the last day of the fiscal year in which such termination occurred; and 
 (iii)
A Pro Rata Bonus. 
 Following Executive’s death or a termination of Executive’s employment by reason of a Disability, except as set forth in this
Section 8(b), Executive shall have no further rights to any compensation or any other benefits under this Agreement. 
 (c)
Termination by the Company with Cause. 
 (i) The Company may terminate Executive’s employment at any time with Cause, effective
upon Executive’s receipt of written notice of such termination; provided, however, that with respect to any Cause termination relying on clause (ii) or (vi) of the definition of Cause set forth in paragraph (h) in
Appendix A to this Agreement, to the extent that such act or acts or failure or failures to act are curable, Executive shall be given not less than ten (10) days’ written notice by the Board of the Company’s intention to
terminate him with Cause, such notice to state in detail the particular act or acts or failure or failures to act that constitute the grounds on which the proposed termination with Cause is based, and such termination shall be effective at the
expiration of such ten (10) day notice period unless Executive has fully cured such act or acts or failure or failures to act that give rise to Cause during such period. 

(ii) In the event that the Company terminates Executive’s employment with Cause, Executive shall be entitled only to the Accrued
Obligations. Following such termination of Executive’s employment with Cause, except as set forth in this Section 8(c)(ii), Executive shall have no further rights to any compensation or any other benefits under this Agreement. 

  
 5 

 (d) Termination by the Company without Cause. The Company may terminate Executive’s
employment at any time without Cause, effective upon Executive’s receipt of written notice of such termination. In the event that Executive’s employment is terminated by the Company without Cause (other than due to death or Disability),
Executive shall be entitled to: 
 (i) The Accrued Obligations; 

(ii) Any unpaid Annual Bonus in respect of any completed fiscal year that has ended prior to the date of such termination, which amount shall
be paid at such time annual bonuses are paid to other senior executives of the Company, but in no event later than the date that is two and one-half (2 1⁄2) months following the last day of the fiscal year in which such termination occurred; 
 (iii) A
Pro Rata Bonus; 
 (iv) Payment of an amount equal to (x) one and one-half (1.5) (provided, such
multiple shall be equal to two (2), if the date of such termination occurs within three (3) months prior to or twelve (12) months following the consummation of a Change in Control), multiplied by (y) the sum of Base Salary plus Target
Annual Bonus, payable during the Severance Term in equal installments in accordance with the Company’s regular payroll practices; 
 (v)
To the extent permitted by applicable law without any penalty to Executive or any member of the Company Group and subject to Executive’s election of COBRA continuation coverage under the Company’s group health plan, on the first regularly
scheduled payroll date of each month of the COBRA Continuation Period, the Company will pay Executive an amount equal to the “applicable percentage” of the monthly COBRA premium cost; provided, that the payments pursuant to this
clause (v) shall cease earlier than the expiration of the COBRA Continuation Period in the event that Executive becomes eligible to receive any health benefits, including through a spouse’s employer, during the COBRA Continuation Period.
For purposes hereof, the “applicable percentage” shall be the percentage of Executive’s health care premium costs covered by the Company as of the date of termination. Amounts paid by the Company on behalf of
Executive pursuant to this clause (v) shall be imputed to Executive as additional taxable income to the minimum extent as may be required to avoid adverse consequences to Executive or the Company under either Section 105(h) of the Code or
the Patient Protection and Affordable Care Act of 2010; provided that, if such imputation does not prevent the imposition of an excise tax under, or the violation of, the Patient Protection and Affordable Care Act (as amended by the Health Care and
Education Reconciliation Act of 2010 and as amended from time to time), including, without limitation, Section 4980D of the Code, the Company shall no longer provide for payment of such medical and dental benefits to Executive (without
otherwise limiting Executive’s rights to continuation coverage under applicable law at his personal expense); and 
 (vi) If the date of
such termination occurs within twelve (12) months following the consummation of a Change in Control and any equity award previously granted to Executive and then-unvested and outstanding (including the Initial Stock Option Grant and the Initial
Restricted Stock Unit Grant) is assumed or substituted in connection with such Change in 

  
 6 

 
Control, any such equity award, that is subject to solely service-based vesting, shall become fully vested and non-forfeitable as of the date of such
termination of Executive’s employment, it being understood that if any equity award (other than the Initial Stock Option Grant or the Initial Restricted Stock Unit Grant) is not expressly assumed in a Change in Control, the treatment of the
equity award in the Change in Control shall be determined by the Compensation Committee consistent with other active senior executives; provided, that any such equity award that is subject to performance vesting requirements will be treated in all
events in the same manner as equity awards subject to performance vesting held by other senior executives. Upon any such termination prior to a Change in Control, any then unvested equity awards held by Executive shall remain outstanding but will
not vest, and will terminate and be forfeited without consideration on the three (3) month anniversary following such termination unless a Change in Control occurs during such three (3) month period; provided that if a Change in Control
occurs during the three (3) month period, the unvested equity awards held by Executive shall become vested in accordance with the terms of this Section 8(d)(vi) as though he had experienced such termination of employment on the day
immediately following such Change in Control. 
 Notwithstanding the foregoing, the payments and benefits described in clauses (ii), (iii), (iv) and
(v) above shall immediately terminate, and the Company shall have no further obligations to Executive with respect thereto, in the event that Executive breaches any provision of the Restrictive Covenant Agreement. Following such termination of
Executive’s employment by the Company without Cause, except as set forth in this Section 8(d), Executive shall have no further rights to any compensation or any other benefits under this Agreement. For the avoidance of doubt,
Executive’s sole and exclusive remedy upon a termination of employment by the Company without Cause shall be receipt of the Severance Benefits. 

(e) Termination by Executive with Good Reason. Executive may terminate Executive’s employment with Good Reason by providing the
Company ten (10) days’ written notice setting forth in reasonable specificity the event that constitutes Good Reason, which written notice, to be effective, must be provided to the Company within sixty (60) days of the occurrence of
such event. During such ten (10) day notice period, the Company shall have a cure right (if curable), and if not cured within such period, Executive’s termination will be effective upon the expiration of such cure period, and Executive
shall be entitled to the same payments and benefits as provided in Section 8(d) hereof for a termination by the Company without Cause, subject to the same conditions on payment and benefits as described in Section 8(d) hereof. Following
such termination of Executive’s employment by Executive with Good Reason, except as set forth in this Section 8(e), Executive shall have no further rights to any compensation or any other benefits under this Agreement. For the avoidance of
doubt, Executive’s sole and exclusive remedy upon a termination of employment with Good Reason shall be receipt of the Severance Benefits. 

(f) Termination by Executive without Good Reason. Executive may terminate Executive’s employment without Good Reason by providing
the Company thirty (30) days’ written notice of such termination. In the event of a termination of employment by Executive under this Section 8(f), Executive shall be entitled only to the Accrued Obligations. In the event of
termination of Executive’s employment under this Section 8(f), the Company may, in its sole and absolute discretion, by written notice accelerate such date of termination without changing the characterization of such termination as a
termination by Executive without Good Reason. Following such termination of Executive’s employment by Executive without Good Reason, except as set forth in this Section 8(f), Executive shall have no further rights to any compensation or
any other benefits under this Agreement. 

  
 7 

 (g) Release. Notwithstanding any provision herein to the contrary, the payment of any
amount or provision of any benefit pursuant to subsection (b), (d), or (e) of this Section 8 (other than the Accrued Obligations) (collectively, the “Severance Benefits”) shall be conditioned upon Executive’s
execution, delivery to the Company, and non-revocation of the Release of Claims (and the expiration of any revocation period contained in such Release of Claims) within sixty (60) days following the date
of Executive’s termination of employment hereunder. If Executive fails to execute the Release of Claims in such a timely manner so as to permit any revocation period to expire prior to the end of such sixty (60) day period, or timely
revokes Executive’s acceptance of such release following its execution, Executive shall not be entitled to any of the Severance Benefits. Further, (i) to the extent that any of the Severance Benefits constitutes “nonqualified deferred
compensation” for purposes of Section 409A of the Code, any payment of any amount or provision of any benefit otherwise scheduled to occur prior to the sixtieth (60th) day following the
date of Executive’s termination of employment hereunder, but for the condition on executing the Release of Claims as set forth herein, shall not be made until the first regularly scheduled payroll date following such sixtieth (60th) day and (ii) to the extent that any of the Severance Benefits do not constitute “nonqualified deferred compensation” for purposes of Section 409A of the Code, any payment of any
amount or provision of any benefit otherwise scheduled to occur following the date of Executive’s termination of employment hereunder, but for the condition on executing the Release of Claims as set forth herein, shall not be made until the
first regularly scheduled payroll date following the date the Release of Claims is timely executed and the applicable revocation period has ended, after which, in each case, any remaining Severance Benefits shall thereafter be provided to Executive
according to the applicable schedule set forth herein. For the avoidance of doubt, in the event of a termination due to Executive’s death or Disability, Executive’s obligations herein to execute and not revoke the Release of Claims may be
satisfied on Executive’s behalf by Executive’s estate or a person having legal power of attorney over Executive’s affairs. 

Section 9. Restrictive Covenant Agreement. 

As a condition of, and prior to commencement of, Executive’s employment with the Company, Executive shall have executed and delivered to
the Company the Restrictive Covenant Agreement. The parties hereto acknowledge and agree that this Agreement and the Restrictive Covenant Agreement shall be considered separate contracts, and the Restrictive Covenant Agreement will survive the
termination of this Agreement for any reason. 
 Section 10. Representations and Warranties of Executive. 

Executive represents and warrants to the Company that— 

(a) Executive is entering into this Agreement voluntarily and that Executive’s employment hereunder and compliance with the terms and
conditions hereof will not conflict with or result in the breach by Executive of any agreement to which Executive is a party or by which Executive may be bound; 

  
 8 

 (b) Executive has not violated, and in connection with Executive’s employment with the
Company will not violate, any non-solicitation, non-competition, or other similar covenant or agreement of a prior employer by which Executive is or may be bound; and

 (c) in connection with Executive’s employment with the Company, Executive will not use any confidential or proprietary information
Executive may have obtained in connection with employment with any prior employer. 
 Section 11. Taxes. 

The Company may withhold from any payments made under this Agreement all applicable taxes, including but not limited to income, employment, and
social insurance taxes, as shall be required by law. Executive acknowledges and represents that the Company has not provided any tax advice to Executive in connection with this Agreement and that Executive has been advised by the Company to seek tax
advice from Executive’s own tax advisors regarding this Agreement and payments that may be made to Executive pursuant to this Agreement, including specifically, the application of the provisions of Section 409A of the Code to such
payments. 
 Section 12. Set Off; Mitigation. 

The Company’s obligation to pay Executive the amounts provided and to make the arrangements provided hereunder shall be subject to set-off, counterclaim, or recoupment of undisputed amounts owed by Executive to the Company or its affiliates; provided, however, that to the extent any amount so subject to set-off, counterclaim, or recoupment is payable in installments hereunder, such set-off, counterclaim, or recoupment shall not modify the applicable payment date of any
installment, and to the extent an obligation cannot be satisfied by reduction of a single installment payment, any portion not satisfied shall remain an outstanding obligation of Executive and shall be applied to the next installment only at such
time the installment is otherwise payable pursuant to the specified payment schedule. Executive shall not be required to mitigate the amount of any payment or benefit provided pursuant to this Agreement by seeking other employment or otherwise, and
except as provided in Section 8(d)(v) hereof, the amount of any payment or benefit provided for pursuant to this Agreement shall not be reduced by any compensation earned as a result of Executive’s other employment or otherwise. 

Section 13. Additional Section 409A Provisions. 

Notwithstanding any provision in this Agreement to the contrary— 

(a) Any payment otherwise required to be made hereunder to Executive at any date as a result of the termination of Executive’s employment
shall be delayed for such period of time as may be necessary to meet the requirements of Section 409A(a)(2)(B)(i) of the Code (the “Delay Period”). On the first business day following the expiration of the Delay
Period, Executive shall be paid, in a single cash lump sum, an amount equal to the aggregate amount of all payments delayed pursuant to the preceding sentence, and any remaining payments not so delayed shall continue to be paid pursuant to the
payment schedule set forth herein. 

  
 9 

 (b) Each payment in a series of payments hereunder shall be deemed to be a separate payment for
purposes of Section 409A of the Code. 
 (c) To the extent that any right to reimbursement of expenses or payment of any benefit in-kind under this Agreement constitutes nonqualified deferred compensation (within the meaning of Section 409A of the Code), (i) any such expense reimbursement shall be made by the Company no later than the
last day of the taxable year following the taxable year in which such expense was incurred by Executive, (ii) the right to reimbursement or in-kind benefits shall not be subject to liquidation or exchange
for another benefit, and (iii) the amount of expenses eligible for reimbursement or in-kind benefits provided during any taxable year shall not affect the expenses eligible for reimbursement or in-kind benefits to be provided in any other taxable year; provided, that the foregoing clause shall not be violated with regard to expenses reimbursed under any arrangement covered by
Section 105(b) of the Code solely because such expenses are subject to a limit related to the period the arrangement is in effect. 

(d) While the payments and benefits provided hereunder are intended to be structured in a manner to avoid the implication of any penalty taxes
under Section 409A of the Code, in no event whatsoever shall the Company or any of its affiliates (including, without limitation, the Company) be liable for any additional tax, interest, or penalties that may be imposed on Executive as a result
of Section 409A of the Code or any damages for failing to comply with Section 409A of the Code (other than for withholding obligations or other obligations applicable to employers, if any, under Section 409A of the Code). 

Section 14. Golden Parachute Tax Provision. 

If there is a change in ownership or control of the Company that would cause any payment or distribution by the Company or any other Person or
entity to Executive or for Executive’s benefit (whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise) (a “Payment”) to be subject to the excise tax imposed by
Section 4999 of the Code (such excise tax, together with any interest or penalties incurred by Executive with respect to such excise tax, the “Excise Tax”), then Executive will receive the greatest of the following,
whichever gives Executive the highest net after-tax amount (after taking into account federal, state, local and social security taxes): (a) the Payments or (b) one dollar less than the amount of the
Payments that would subject Executive to the Excise Tax (the “Safe Harbor Amount”). If a reduction in the Payments is necessary so that the Payments equal the Safe Harbor Amount and none of the Payments constitutes
nonqualified deferred compensation (within the meaning of Section 409A of the Code), then the reduction shall occur in the manner Executive elects in writing prior to the date of payment. If any Payment constitutes nonqualified deferred
compensation or if Executive fails to elect an order, then the Payments to be reduced will be determined in a manner which has the least economic cost to Executive and, to the extent the economic cost is equivalent, will be reduced in the inverse
order of when payment would have been made to Executive, until the reduction is achieved. All determinations required to be made under this Section 14, including whether and when the Safe Harbor Amount is required and the amount of the
reduction of the Payments and the assumptions to be utilized in arriving at such determination, shall be made by an independent, certified public accounting firm designated by the Company (the “Accounting Firm”). All
fees and expenses of the Accounting Firm shall be borne solely by the Company. Any determination by the Accounting Firm shall be binding upon Company and Executive. 

  
 10 

 Section 15. Clawbacks. 

All payments made pursuant to this Agreement are subject to the “clawback” obligations of Section 954 of the Dodd-Frank Wall
Street Reform and Consumer Act, as may be amended from time to time, and any other “clawback” obligations pursuant to applicable law, rule, regulation or Company policy, in each case as consistently applied to all similarly situated
executives of the Company. 
 Section 16. Successors and Assigns; No Third-Party Beneficiaries. 

(a) The Company. This Agreement shall inure to the benefit of the Company and its respective successors and assigns. Neither this
Agreement nor any of the rights, obligations, or interests arising hereunder may be assigned by the Company to a Person (other than another member of the Company Group, or its or their respective successors) without Executive’s prior written
consent (which shall not be unreasonably withheld, delayed, or conditioned); provided, however, that in the event of a sale of all or substantially all of the assets of the Company or any direct or indirect division or subsidiary
thereof to which Executive’s employment primarily relates, the Company may provide that this Agreement will be assigned to, and assumed by, the acquiror of such assets, it being agreed that in such circumstances, Executive’s consent will
not be required in connection therewith. In the event of any assignment or assumption of this Agreement or the Restrictive Covenant Agreement in connection with a sale of all or substantially all of the assets of the Company or any direct or
indirect division or subsidiary thereof to which Executive’s employment primarily relates, the scope and applicability of Executive’s noncompetition and customer nonsolicitation covenants under the Restrictive Covenant Agreement (or any
other agreement entered into by Executive and the Company prior to such sale) will be determined as of immediately prior to such sale, unless Executive shall otherwise agree or shall continue his employment pursuant to this Agreement and the
Restrictive Covenant Agreement for at least six months following such sale. 
 (b) Executive. Executive’s rights and obligations
under this Agreement shall not be transferable by Executive by assignment or otherwise, without the prior written consent of the Company; provided, however, that if Executive shall die, all amounts then payable to Executive hereunder
(including future unpaid installments thereof) shall be paid in accordance with the terms of this Agreement to Executive’s devisee, legatee, or other designee, or if there be no such designee, to Executive’s estate. 

(c) No Third-Party Beneficiaries. Except as otherwise set forth in Section 8(b) or Section 16(b) hereof, nothing expressed or
referred to in this Agreement will be construed to give any Person other than the Company, the other members of the Company Group, and Executive any legal or equitable right, remedy, or claim under or with respect to this Agreement or any provision
of this Agreement. 

  
 11 

 Section 17. Waiver and Amendments. 

Any waiver, alteration, amendment, or modification of any of the terms of this Agreement shall be valid only if made in writing and signed by
each of the parties hereto; provided, however, that any such waiver, alteration, amendment, or modification must be consented to on the Company’s behalf by the Board. No waiver by either of the parties hereto of their rights
hereunder shall be deemed to constitute a waiver with respect to any subsequent occurrences or transactions hereunder unless such waiver specifically states that it is to be construed as a continuing waiver. 

Section 18. Severability. 

If any covenants or such other provisions of this Agreement are found to be invalid or unenforceable by a final determination of a court of
competent jurisdiction, (a) the remaining terms and provisions hereof shall be unimpaired, and (b) the invalid or unenforceable term or provision hereof shall be deemed replaced by a term or provision that is valid and enforceable and that
comes closest to expressing the intention of the invalid or unenforceable term or provision hereof. 
 Section 19. Governing Law and
Jurisdiction. 
 THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF DELAWARE, APPLICABLE TO
AGREEMENTS MADE AND TO BE PERFORMED IN THAT STATE, WITHOUT REGARD TO CONFLICT OF LAWS RULES. ANY DISPUTE, CONTROVERSY OR CLAIM BETWEEN EXECUTIVE AND THE COMPANY ARISING OUT OF THIS AGREEMENT OR THE RESTRICTIVE COVENANT AGREEMENT SHALL BE RESOLVED BY
ARBITRATION ADMINISTERED BY THE AMERICAN ARBITRATION ASSOCIATION (“AAA”) IN ACCORDANCE WITH ITS EMPLOYMENT ARBITRATION RULES INCLUDING THE EMERGENCY INTERIM RELIEF PROCEDURES OF THE AAA. JUDGMENT ON THE AWARD RENDERED BY THE
ARBITRATOR(S) MAY BE ENTERED IN ANY COURT HAVING JURISDICTION THEREOF. THE PLACE OF ARBITRATION SHALL BE WILMINGTON, DELAWARE. THE ARBITRATOR(S) MAY GRANT INJUNCTIONS OR OTHER RELIEF IN SUCH DISPUTE OR CONTROVERSY. THE DECISION OF THE ARBITRATOR(S)
SHALL BE FINAL, CONCLUSIVE AND BINDING ON THE PARTIES TO THE ARBITRATION. EXCEPT AS SPECIFICALLY SET FORTH HEREIN, THE COMPANY SHALL PAY ALL ARBITRATOR’S FEES AND EXPENSES AND EXECUTIVE AND THE COMPANY SHALL EACH BEAR THEIR OWN ATTORNEYS’
FEES INCURRED IN CONNECTION WITH THE ARBITRATION, AND THE ARBITRATOR(S) WILL NOT HAVE AUTHORITY TO BE ENTITLED TO AWARD ATTORNEYS’ FEES UNLESS A STATUTE OR CONTRACT AT ISSUE IN THE DISPUTE AUTHORIZES THE AWARD OF ATTORNEYS’ FEES TO THE
PREVAILING PARTY, IN WHICH CASE THE 
ARBITRATOR(S) SHALL HAVE THE AUTHORITY TO MAKE AN AWARD OF ATTORNEYS’ FEES AS REQUIRED OR PERMITTED BY APPLICABLE LAW. IF THERE IS A DISPUTE AS TO WHETHER THE COMPANY OR EXECUTIVE IS THE PREVAILING PARTY
IN THE ARBITRATION, THE ARBITRATOR(S) WILL DECIDE THIS ISSUE. LIABILITY FOR THE FEES AND EXPENSES OF ALL THE ARBITRATORS WITH RESPECT TO THE 

  
 12 

 
ARBITRATION SHALL BE EVENLY DIVIDED BETWEEN THE PARTIES TO THE ARBITRATION. THE DETERMINATION RENDERED BY THE ARBITRATOR(S) SHALL (I) SPECIFY THE FINDING OF FACTS UPON WHICH IT IS BASED AND
THE REASONS THEREFOR, AND (II) BE CONCLUSIVE AND BINDING UPON THE PARTIES. NOTWITHSTANDING THE PROVISIONS OF THIS PARAGRAPH, THE COMPANY SHALL NOT BE COMPELLED TO ARBITRATE CLAIMS ARISING UNDER THE RESTRICTIVE COVENANT AGREEMENT AND MAY
INSTITUTE JUDICIAL PROCEEDINGS TO ENFORCE THAT AGREEMENT PURSUANT TO THE RESTRICTICE COVENANT AGREEMENT. EXECUTIVE HEREBY AGREES TO SUBMIT ANY AND ALL CLAIMS EXECUTIVE MAY HAVE AGAINST THE COMPANY ON AN INDIVIDUAL BASIS. THIS MEANS THAT NO CLAIM
(INCLUDING ANY CLAIM RELATED TO TERMS OR CONDITIONS OF EXECUTIVE’S EMPLOYMENT WITH OR COMPENSATION PAID BY THE COMPANY, OR ANY CHANGE IN OR TERMINATION OF EXECUTIVE’S EMPLOYMENT) MAY BE LITIGATED OR ARBITRATED ON A CLASS OR COLLECTIVE
BASIS. EXECUTIVE ALSO HEREBY WAIVES ANY RIGHT TO SUBMIT, INITIATE, OR PARTICIPATE IN A REPRESENTATIVE CAPACITY OR AS A PLAINTIFF, CLAIMANT, OR MEMBER IN A CLASS ACTION, COLLECTIVE ACTION, OR OTHER REPRESENTATIVE OR JOINT ACTION AGAINST THE COMPANY,
REGARDLESS OF WHETHER THE ACTION IS FILED IN ARBITRATION OR IN A JUDICIAL OR ADMINISTRATIVE FORUM. FURTHERMORE, IF A COURT ORDERS THAT A CLASS, COLLECTIVE, OR OTHER REPRESENTATIVE OR JOINT ACTION SHOULD PROCEED, IN NO EVENT WILL SUCH ACTION PROCEED
IN AN ARBITRATION FORUM. CLAIMS MAY NOT BE JOINED OR CONSOLIDATED IN ARBITRATION WITH DISPUTES BROUGHT BY ANY OTHER INDIVIDUAL(S), UNLESS AGREED TO IN WRITING BY ALL PARTIES. 

Section 20. Indemnification; D&O Insurance. 

The Company will indemnify and hold Executive harmless for all acts and omissions to act, in the performance of his duties, to the maximum
extent permitted under the Company charter and by-laws and under applicable law. The Company will cover Executive as an insured under any contract of directors and officers liability insurance that covers
other members of the Board. 
 Section 21. Notices. 

(a) Place of Delivery. Every notice or other communication relating to this Agreement shall be in writing, and shall be mailed to or
delivered to the party for whom or which it is intended at such address as may from time to time be designated by it in a notice mailed or delivered to the other party as herein provided; provided, that unless and until some other address be
so designated, all notices and communications shall be mailed or delivered to the following addresses: 
 If to the Company: 

Chairman of the Board/Melinta Therapeutics, Inc. 

c/o Willkie Farr & Gallagher LLP 

787 Seventh Avenue 

  
 13 

 New York, New York 10019 

Attn: Sean M. Ewen, Esq. 
 If
to Executive: 
 Executive’s last known address, as reflected in the Company’s records. 

(b) Date of Delivery. Any notice so addressed shall be deemed to be given or received (i) if delivered by hand, on the date of such
delivery, (ii) if mailed by courier or by overnight mail, on the first business day following the date of such mailing, and (iii) if mailed by registered or certified mail, on the third business day after the date of such mailing. 

Section 22. Section Headings. 

The headings of the sections and subsections of this Agreement are inserted for convenience only and shall not be deemed to constitute a part
thereof or affect the meaning or interpretation of this Agreement or of any term or provision hereof. 
 Section 23. Entire
Agreement. 
 This Agreement, together with any exhibits attached hereto, constitutes the entire understanding and agreement of the
parties hereto regarding the employment of Executive. This Agreement supersedes all prior negotiations, discussions, correspondence, communications, understandings, and agreements between the parties relating to the subject matter of this Agreement.

 Section 24. Survival of Operative Sections. 

Upon any termination of Executive’s employment, the provisions of Section 8 through Section 25 of this Agreement (together with
any related definitions set forth in Appendix A to this Agreement) shall survive to the extent necessary to give effect to the provisions thereof. 

Section 25. Counterparts. 

This Agreement may be executed in two (2) or more counterparts, each of which shall be deemed to be an original but all of which together
shall constitute one and the same instrument. The execution of this Agreement may be by actual signature or by signature delivered by facsimile or by e-mail as a portable document format (.pdf) file or image
file attachment. 
 Section 26. Effectiveness. 

This Agreement shall be conditioned upon the closing of the transactions contemplated by the Acquisition Agreement. In the event that the
Acquisition Agreement terminates prior to the closing of the transactions contemplated thereby, this Agreement shall be void ab initio. 

* * * 
 [Signatures to appear
on the following page(s).] 

  
 14 

 IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the date first above
written. 
  

			
	MELINTA THERAPEUTICS, INC.
		
	By:	 	 /s/ Thomas Koestler

		 	 Thomas Koestler

	Title:	 	Chairman
	
	EXECUTIVE
	
	 /s/ Daniel Mark Wechsler

	Daniel Mark Wechsler

 [Signature Page to D. Wechsler Employment Agreement] 

 Appendix A 

Definitions 
 In this
Appendix A, and in the Agreement unless the context otherwise requires, the following terms shall have the meanings assigned below (unless otherwise specified Section references in this Appendix A are to Sections of this
Agreement): 
 (a) “AAA” shall have the meaning set forth in Section 19 hereof. 

(b) “Accounting Firm” shall have the meaning set forth in Section 14 hereof. 

(c) “Accrued Obligations” shall mean (i) all accrued but unpaid Base Salary through the date of termination of
Executive’s employment and, to the extent payable pursuant to the Company’s policies, accrued but unused vacation through the date of termination of Executive’s employment, (ii) any unpaid or unreimbursed expenses incurred in
accordance with Section 7 hereof, and (iii) any benefits provided under the Company’s employee benefit plans upon a termination of employment (excluding any employee benefit plan providing for severance or similar benefits), in
accordance with the terms contained therein. 
 (d) “Agreement” shall have the meaning set forth in the preamble
hereto. 
 (e) “Annual Bonus” shall have the meaning set forth in Section 4(b) hereof. 

(f) “Base Salary” shall mean the salary provided for in Section 4(a) hereof or any increased salary granted to
Executive pursuant to Section 4(a) hereof. 
 (g) “Board” shall mean the Board of Directors of the Company. 

(h) “Cause” shall mean (i) Executive’s act(s) of gross negligence or willful misconduct in the course of
Executive’s employment hereunder, (ii) willful failure or refusal in any material respect by Executive to perform Executive’s duties or responsibilities, (iii) misappropriation (or attempted misappropriation) by Executive of any
assets or business opportunities of the Company or any other member of the Company Group, (iv) embezzlement or fraud committed (or attempted) by Executive, at Executive’s direction, or with Executive’s prior actual knowledge,
(v) Executive’s conviction of or pleading “guilty” or “ no contest” to, (x) a felony or (y) any other criminal charge that has, or could be reasonably expected to have, an adverse impact on the performance of
Executive’s duties to the Company or any other member of the Company Group or otherwise result in material injury to the reputation or business of the Company or any other member of the Company Group, (vi) any material violation by
Executive of the material policies of the Company, including but not limited to those relating to sexual harassment or business conduct, and those otherwise set forth in the manuals or statements of policy of the Company, or
(vii) Executive’s material breach of this Agreement or breach of the Restrictive Covenant Agreement. If, within ninety (90) days subsequent to Executive’s termination for any reason other than by the Company for Cause, the
Company discovers that Executive’s employment could have been terminated for Cause, Executive’s employment will be deemed to have been terminated for Cause for all purposes, and Executive will be required to disgorge to the Company all
amounts received pursuant to this Agreement or otherwise on account of such termination that would not have been payable to Executive had such termination been by the Company for Cause. 

 (i) “Change in Control” shall have the meaning set forth in the Melinta
Therapeutics, Inc. (f/k/a Cempra, Inc.) 2011 Equity Incentive Plan, as amended from time to time. 
 (j) “COBRA”
shall mean Part 6 of Title I of the Employee Retirement Income Security Act of 1974, as amended, and Section 4980B of the Code, and the rules and regulations promulgated under either of them. 

(k) “COBRA Continuation Period” shall mean the eighteen (18) month period following Executive’s termination
by the Company without Cause (other than by reason of death or Disability) or by Executive for Good Reason. 
 (l)
“Code” shall mean the Internal Revenue Code of 1986, as amended, and the rules and regulations promulgated thereunder. 

(m) “Commencement Date” shall have the meaning set forth in Section 2 hereof. 

(n) “Company” shall have the meaning set forth in the preamble hereto. 

(o) “Company Group” shall mean the Company together with any direct or indirect subsidiaries of the Company. 

(p) “Compensation Committee” shall mean the Compensation Committee of the Board. 

(q) “Excise Tax” shall have the meaning set forth in Section 14 hereof. 

(r) “Delay Period” shall have the meaning set forth in Section 13(a) hereof. 

(s) “Disability” shall mean any physical or mental disability or infirmity of Executive that prevents the performance
of Executive’s duties for a period of (i) ninety (90) consecutive days or (ii) one hundred twenty (120) non-consecutive days during any twelve (12) month period. Any question as
to the existence, extent, or potentiality of Executive’s Disability upon which Executive and the Company cannot agree shall be determined by a qualified, independent physician selected by the Company. The determination of any such physician
shall be final and conclusive for all purposes of this Agreement. 
 (t) “Executive” shall have the meaning set forth
in the preamble hereto. 
 (u) “Good Reason” shall mean, without Executive’s consent, (i) a material
diminution in Executive’s title, duties, or responsibilities (including reporting requirements) as set forth in Section 3 hereof (it being acknowledged and agreed that (a) such event shall occur if Executive is not the most senior
officer of the most senior parent company resulting from and immediately following any Change in Control and (b) such event shall not occur solely by reason of the Company’s hiring or appointment of a new President, with all related duties
and 

  
 A-2 

 
responsibilities, and the resulting change in Executive’s title, duties or responsibilities so long as Executive retains the office of the Chief Executive Officer and any President reports
solely and directly to Executive), (ii) a material reduction in Base Salary set forth in Section 4(a) hereof or Annual Bonus opportunity set forth in Section 4(b) hereof (other than pursuant to an across-the-board reduction applicable in like proportions to all similarly situated executives of the Company), (iii) any other material breach of a provision of this Agreement by the Company (other than
a provision that is covered by clause (i) or (ii) above), or (iv) any failure of the Company to assign to a successor, for such successor to assume, this Agreement in connection with a Change in Control. Executive acknowledges and agrees
that Executive’s exclusive remedy in the event of any breach of this Agreement shall be to assert Good Reason pursuant to the terms and conditions of Section 8(e) hereof. 

(v) “Initial Stock Option Grant” shall have the meaning set forth in Section 4(c) hereof. 

(w) “Initial Restricted Stock Unit Grant” shall have the meaning set forth in Section 4(c). 

(x) “Payment” shall have the meaning set forth in Section 14 hereof. 

(y) “Person” shall mean any individual, corporation, partnership, limited liability company, joint venture,
association, joint-stock company, trust (charitable or non-charitable), unincorporated organization, or other form of business entity. 

(z) “Pro Rata Bonus” shall mean an Annual Bonus payable in such amount as is earned based on achievement of the
applicable performance goals for the fiscal year in which such death or other termination occurs as determined by the Compensation Committee (disregarding any negative discretion exercised by the Compensation Committee to the extent such exercise
does not apply to all bonus plan participants with like effect, and treating any and all personal performance objectives of Executive as fully satisfied), prorated based on the ratio of the number of days employed during the fiscal year through the
date of death or other employment termination to 365, and payable when annual bonuses are paid to other active senior executives. 
 (aa)
“Release of Claims” shall mean the Release of Claims in substantially the same form attached hereto as Exhibit B (as the same may be revised from time to time by the Company upon the advice of counsel). 

(bb) “Restrictive Covenant Agreement” shall mean the Employee Noncompetition, Nondisclosure and Developments Agreement
attached hereto as Exhibit A. 
 (cc) “Safe Harbor Amount” shall have the meaning set forth in Section 14
hereof. 
 (dd) “Severance Benefits” shall have the meaning set forth in Section 8(g) hereof. 

(ee) “Severance Term” shall mean the eighteen (18) month period following Executive’s termination by the
Company without Cause (other than by reason of death or Disability) or by Executive for Good Reason. 

  
 A-3 

 (ff) “Term” shall mean the period specified in Section 2 hereof.

  
 A-4 

 Exhibit A 

EMPLOYEE NONCOMPETITION, 

NONDISCLOSURE AND DEVELOPMENTS AGREEMENT 

This Employee Noncompetition, Nondisclosure and Developments Agreement (the “Agreement”) is entered into by and between
Daniel Mark Wechsler the undersigned employee and Melinta Therapeutics, Inc., its parents, affiliates and subsidiaries (the “Company”) on the date set forth beneath the parties’ signatures (the “Effective
Date”). 
 NOW THEREFORE, in consideration of my employment by the Company pursuant to the employment agreement entered into with
the Company contemporaneous with this Agreement (“Employment Agreement”) and of the covenants herein, and for other good and valuable consideration, I hereby covenant and agree as follows: 

 

	1.	Noncompetition. 

 During the period of my employment by the Company, I shall not,
directly or indirectly, alone or as a consultant, partner, officer, director, employee, joint venturer, lender or stockholder of any entity, engage in any business or activity that is in competition with the products or services being created,
developed, manufactured, marketed, distributed or sold by the Company in (a) the United States or (b) worldwide. For the eighteen (18) month period following the termination of my employment, regardless of the reasons for my
termination, I will not engage in the management of or participation in programs at or on behalf of any entity in the business of developing, marketing or selling antimicrobial products or other specific chemical approaches or series the Company is
engaged in during my employment or in which the Company is planning to engage or has in the previous twelve (12) months engaged. In the case of areas of business unrelated to antimicrobials, for the eighteen (18) month period following the
termination of my employment, regardless of the reasons for my termination, I will not engage in the management of or participation in any such other non-antimicrobial programs which are under prosecution at
the Company, in which the Company is planning to engage or has in the immediately previous twelve (12) months engaged in, and which are directly competitive with the Company. Prohibited activities under the immediately preceding two sentences
are referred to as “Competitive” products. The foregoing provisions of this Section 1 to the contrary notwithstanding, this Section 1 shall not apply to any such entity engaged in the development, marketing or sale of
diversified products that include Competitive products if not more than twenty percent (20%) of such entity’s aggregate annual revenues for the immediately preceding eight (8) completed fiscal quarters are from the sale of Competitive
products; provided, that, I first recuse myself from, and am in no way involved with, the division of such entity that is engaged in the development, marketing or sale of any Competitive products. 

 

	2.	Nonsolicitation of Customers. 

 During the period of my employment by the Company and for
the eighteen (18) month period following the termination of my employment, regardless of the reasons for my termination, I shall not, directly or indirectly, alone or as a consultant, partner, officer, director, employee, joint venturer, lender
or stockholder of any entity, solicit or do business with any customer of the Company or any potential customer of the Company (i) with whom I have had contact or (ii) about whom I obtained information, or became familiar with through
Confidential Information (as defined in Paragraph 5), during the course of my employment with the Company, for the purpose of developing, marketing or selling Competitive products. 

 

                       
    
 Initial and Date 

	3.	Nonsolicitation of Employees. 

 (a) During the period of my employment by the Company and
for the eighteen (18) month period following the termination of my employment, regardless of the reasons for the termination, I will not, in any manner, hire or engage, or assist any company or business organization by which I am employed or
which is directly or indirectly controlled by me to hire or engage, any person who is or was employed by the Company (or is or was an individual independent contractor providing significant services to the Company) within the twelve (12) month
period prior to the date of such hiring. 
 (b) During the period of my employment by the Company and for the eighteen (18) month period
following the termination of my employment, regardless of the reasons for the termination, I will not, in any manner, solicit, recruit or induce, or assist any company or business organization by which I am employed or which is directly or
indirectly controlled by me to solicit, recruit or induce, any person who is or was employed by the Company (or is or was an individual independent contractor providing significant services to the Company) within the twelve (12) month period
prior to the date of such hiring, to leave his or her employment, relationship or engagement with the Company. 
 (c) Further, during the
period of my employment by the Company and for the eighteen (18) month period following the termination of my employment, regardless of the reasons for the termination, I shall not interfere with the Company’s relationship with any agent,
representative, contractor, project consultant or consultant then engaged by the Company. 
  

	4.	Nondisclosure. 

 I shall not at any time, whether during or after the termination of my
employment, reveal to any person or entity any Confidential Information except to (a) employees of the Company who need to know such Confidential Information for the purposes of their employment, (b) others as I reasonably determine
appropriate to discharge my duties with the Company, or (c) as otherwise authorized by the Company in writing. The term “Confidential Information” shall include any information concerning the organization, business or finances
of the Company or of any third party which the Company is under an obligation to keep confidential that is maintained by the Company as confidential. Such Confidential Information shall include, but is not limited to, trade secrets or confidential
information respecting inventions, products, designs, methods, know-how, techniques, systems, processes, specifications, blueprints, engineering data, software programs, works of authorship, customer lists,
customer information, financial information, pricing information, personnel information, business plans, projects, plans and proposals. I shall keep confidential all matters entrusted to me and shall not use or attempt to use any Confidential
Information except as may be required in the ordinary course of performing my duties as an employee of the Company, nor shall I use any Confidential Information in any manner which may injure or cause loss or may be calculated to injure or cause
loss to the Company, whether directly or indirectly. 

  
 - 2 - 

	5.	Assignment of Developments. 

 (a) If at any time or times during my employment, I shall
(either alone or with others) make, conceive, create, discover, invent or reduce to practice any Development that (i) relates to the business of the Company or any customer of or supplier to the Company or any of the products or services being
developed, manufactured or sold by the Company or which may be used in relation therewith; or (ii) results from tasks assigned to me by the Company; or (iii) results from the use of premises or personal property (whether tangible or
intangible) owned, leased or contracted for by the Company, then all such Developments and the benefits thereof are and shall immediately become the sole and absolute property of the Company and its assigns, as works made for hire or otherwise. The
term “Development” shall mean any invention, modification, discovery, design, development, improvement, process, software program, work of authorship, documentation, formula, data, technique,
know-how, trade secret or intellectual property right whatsoever or any interest therein (whether or not patentable or registrable under copyright, trademark or similar statutes (including, but not limited to,
the Semiconductor Chip Protection Act) or subject to analogous protection). I shall promptly disclose to the Company (or any persons designated by it) each such Development. I hereby assign all rights (including, but not limited to, rights to
inventions, patentable subject matter, copyrights and trademarks) I may have or may acquire in the Developments and all benefits and/or rights resulting therefrom to the Company and its assigns without further compensation and shall communicate,
without cost or delay, and without disclosing to others the same, all available information relating thereto (with all necessary plans and models) to the Company. 

(b) Excluded Developments. I represent that the Developments identified in the Appendix, if any, attached hereto comprise all the
Developments that I have made or conceived prior to my employment by the Company and that are owned or controlled by me, which Developments are excluded from this Agreement. I understand that it is only necessary to list the title of such
Developments and the purpose thereof but not details of the Development itself. If no Developments are identified in the Appendix, it will be deemed that there are no such exclusions. 

 

	 	(gg)	6. Whistleblower; Defend Trade Secrets Act Disclosure. 

 In addition, I understand that
nothing in this Agreement shall be construed to prohibit me from reporting possible violations of law or regulation to any governmental agency or regulatory body or making other disclosures that are protected under any law or regulation, or from
filing a charge with or participating in any investigation or proceeding conducted by any governmental agency or regulatory body. 
 I
understand that the Defend Trade Secrets Act provides that I may not be held criminally or civilly liable under any Federal or state trade secret law for the disclosure of a trade secret that is made in confidence to a Federal, state, or local
government official, either directly or indirectly, or to an attorney, and solely for the purpose of reporting or investigating a suspected violation of law; or that is made in a complaint or other document filed in a lawsuit or other proceeding, if
such filing is made under seal. In the event that I file a lawsuit for retaliation by the Company for reporting a suspected violation of law, I may disclose the trade secret to my attorney and use the trade secret information in the court
proceeding, if I file any document containing the trade secret under seal and do not disclose the trade secret, except pursuant to court order. 

  
 - 3 - 

	 	(hh)	7. Non-Disparagement. 

 During the period of my
employment by the Company, and at all times thereafter, I will not make any disparaging or defamatory comments regarding the Company or its respective current or former directors, officers, employees or shareholders in any respect or make any
comments concerning any aspect of my relationship with the Company or any conduct or events which precipitated any termination of my employment from the Company. During the period of my employment by the Company, and at all times thereafter, the
Company will not, through any authorized public statement, and will direct the Company’s officers and members of the board of directors not to make any disparaging or defamatory comments regarding me in any respect or make any comments
concerning any aspect of my relationship with the Company or any conduct or events which precipitated any termination of my employment from the Company. However, the Company’s and my obligations under this paragraph 7 shall not apply to
disclosures required by applicable law, regulation, or order of a court or governmental agency. 
  

	8.	Further Assurances. 

 I shall, during my employment and at any time thereafter, at the
request and cost of the Company, promptly sign, execute, make and do all such deeds, documents, acts and things as the Company and its duly authorized officers may reasonably require: 

(a) to apply for, obtain, register and vest in the name of the Company alone (unless the Company otherwise directs) patents, copyrights,
trademarks or other analogous protection in any country throughout the world relating to a Development and when so obtained or vested to renew and restore the same; and 

(b) to defend any judicial, opposition or other proceedings in respect of such applications and any judicial, opposition or other proceeding,
petition or application for revocation of any such patent, copyright, trademark or other analogous protection. 
 If the Company is unable,
after reasonable effort, to secure my signature on any application for patent, copyright, trademark or other analogous protection or other documents regarding any legal protection relating to a Development, whether because of my physical or mental
incapacity or for any other reason whatsoever, I hereby irrevocably designate and appoint the Company and its duly authorized officers and agents as my agent and
attorney-in-fact, to act for and in my behalf and stead to execute and file any such application or applications or other documents and to do all other lawfully
permitted acts to further the prosecution and issuance of patent, copyright or trademark registrations or any other legal protection thereon with the same legal force and effect as if executed by me. 

 

	9.	Employment At Will. 

 I understand that this Agreement does not constitute an implied or
written employment contract and that my employment with the Company is on an “at-will” basis. Accordingly, I understand that either the Company or I may terminate my employment at any time, for any
or no reason, subject to the terms of my Employment Agreement. 

  
 - 4 - 

	10.	Severability. 

 I hereby agree that each provision and the subparts of each provision
herein shall be treated as separate and independent clauses, and the unenforceability of any one clause shall in no way impair the enforceability of any of the other clauses of this Agreement. Moreover, if one or more of the provisions contained in
this Agreement shall for any reason be held to be excessively broad as to scope, activity, subject or otherwise so as to be unenforceable at law, such provision or provisions shall be construed by the appropriate judicial body by limiting or
reducing it or them, so as to be enforceable to the maximum extent compatible with the applicable law as it shall then appear. I hereby further agree that the language of all parts of this Agreement shall in all cases be construed as a whole
according to its fair meaning and not strictly for or against either of the parties. 
 11. Amendments; Waiver. 

Any amendment to or modification of this Agreement, or any waiver of any provision hereof, shall be in writing and signed by the Company. Any
waiver by the Company of a breach of any provision of this Agreement shall not operate or be construed as a waiver of any subsequent breach of such provision or any other provision hereof. 

 

	12.	Survival. 

 This agreement shall be effective as of the Effective Date. The parties
obligations under this Agreement shall survive the termination of my employment regardless of the manner of such termination, in accordance with the terms hereof, and shall be binding, respectively, upon the Company’s successors and assigns and
on my heirs, executors, administrators and legal representatives. 
  

	13.	Assignment. 

 The Company shall have the right to assign this Agreement to its successors
and assigns, and all covenants and agreements hereunder shall inure to the benefit of and be enforceable by said successors or assigns. I may not assign this Agreement. 
  

	14.	Representations. 

 (a) I represent that my employment with the Company and my performance
of all of the terms of this Agreement do not and will not breach any agreement to keep in confidence proprietary information acquired by me in confidence or in trust prior to my employment by the Company. I have not entered into, and I shall not
enter into, any agreement either written or oral in conflict herewith. I agree that in the course of my employment with the Company, if the Company requests that I undertake activities that will cause me to use Confidential Information of my prior
employer, I will inform the Company of that fact. 

  
 - 5 - 

 (b) I agree that the restrictions set forth in this Agreement are reasonable and necessary to
protect specific business interests of the Company. I agree that any breach of this Agreement by me will cause irreparable damage to the Company and that in the event of such breach the Company shall have, in addition to any and all remedies of law,
the right to an injunction, specific performance or other equitable relief to prevent the violation of my obligations hereunder. The Company may apply for such injunctive relief in any court of competent jurisdiction without the necessity of posting
any bond or other security. 
  

	15.	Governing Law; Forum Selection Clause. 

 This Agreement and any claims arising out of
this Agreement (or any other claims arising out of the relationship between the parties) shall be governed by and construed in accordance with the laws of the State of Delaware and shall in all respects be interpreted, enforced and governed under
the internal and domestic laws of such state, without giving effect to the principles of conflicts of laws of such state. Any claims or legal actions by one party against the other shall be commenced and maintained in any state or federal court
located in such state, and I hereby submit to the jurisdiction and venue of any such court. 
  

	16.	Entire Agreement. 

 This Agreement sets forth the complete, sole and entire agreement
between the parties on the subject matter herein and supersedes any and all other agreements, negotiations, discussions, proposals, or understandings, whether oral or written, previously entered into, discussed or considered by the parties 

[Signature to appear on the following page.] 

  
 - 6 - 

 IN WITNESS WHEREOF, the undersigned have executed this Agreement on the Effective Date. 

 

			
	 Melinta Therapeutics, Inc.

		
	 By:
	 	 /s/ Thomas Koestler

		 	 Thomas Koestler

	 Title:
	 	 Chairman

	
	 /s/ Daniel Mark Wechsler

	 Daniel Mark Wechsler

	
	 Address: 

	
	 Date: October 30, 2017

 [Signature Page to Noncompetition, Nondisclosure and Developments Agreement] 

 

                       
      
 Initial and Date 

 (ii) APPENDIX – TITLE/PURPOSE OF DEVELOPMENTS 

The following is a complete list of all Developments owned or controlled by me and the purpose of those Developments: 

If There Are No Developments Check
Here                                     

If There Are Developments Check Here And List Below
                 
 Developments and purpose: 

			
	  
	  	
	  
	  	
	  
	  	
	  
	  	
	  
	  	
	  
	  	

 Exhibit B 

RELEASE OF CLAIMS 

As used in this Release of Claims (this “Release”), the term “claims” will include all claims,
covenants, warranties, promises, undertakings, actions, suits, causes of action, obligations, debts, accounts, attorneys’ fees, judgments, losses, and liabilities, of whatsoever kind or nature, in law, in equity, or otherwise. 

For and in consideration of the Severance Benefits (as defined in my Employment Agreement, dated October [__], 2017, with Melinta
Therapeutics, Inc. (such corporation, the “Company” and such agreement, my “Employment Agreement”)), and other good and valuable consideration, I, Daniel Mark Wechsler, for and on behalf of
myself and my heirs, administrators, executors, and assigns, effective as of the date on which this release becomes effective pursuant to its terms, do fully and forever release, remise, and discharge each of the Company and each of its direct and
indirect subsidiaries and affiliates, and their respective successors and assigns, together with their respective current and former officers, directors, partners, shareholders, employees, and agents (collectively, and with the Company,
the “Group”), from any and all claims whatsoever up to the date hereof that I had, may have had, or now have against the Group, whether known or unknown, for or by reason of any matter, cause, or thing whatsoever,
including any claim arising out of or attributable to my employment or the termination of my employment with the Company, whether for tort, breach of express or implied employment contract, intentional infliction of emotional distress, wrongful
termination, unjust dismissal, defamation, libel, or slander, or under any federal, state, or local law dealing with discrimination based on age, race, sex, national origin, handicap, religion, disability, or sexual orientation. The release of
claims in this Release includes, but is not limited to, all claims arising under the Age Discrimination in Employment Act of 1967 (“ADEA”), Title VII of the Civil Rights Act of 1964, the Americans with Disabilities Act of
1990, the Civil Rights Act of 1991, the Family and Medical Leave Act of 1993, the Employee Retirement Income Security Act of 1974, as amended, the Worker Adjustment and Retraining Notification Act of 1988 and the Equal Pay Act of 1963, each as may
be amended from time to time, and all other federal, state, and local laws, the common law, and any other purported restriction on an employer’s right to terminate the employment of employees. The release contained herein is intended to be a
general release of any and all claims to the fullest extent permissible by law and for the provisions regarding the release of claims against the Group to be construed as broadly as possible, and hereby incorporate in this release similar federal,
state or other laws, all of which I also hereby expressly waive. 
 I understand and agree that claims or facts in addition to or different
from those which are now known or believed by me to exist may hereafter be discovered, but it is my intention to fully and forever release, remise and discharge all claims which I had, may have had, or now have against the Group, whether known or
unknown, suspected or unsuspected, asserted or unasserted, contingent or noncontingent, without regard to the subsequent discovery or existence of such additional or different facts. Without limiting the foregoing, by signing this Release, I
expressly waive and release any provision of law that purports to limit the scope of a general release. 
 I acknowledge and agree that as
of the date I execute this Release, I have no knowledge of any facts or circumstances that give rise or could give rise to any claims under any of the laws listed in the preceding paragraphs. 

  
 B-1 

 By executing this Release, I specifically release all claims relating to my employment and its
termination under the ADEA, a United States federal statute that, among other things, prohibits discrimination on the basis of age in employment and employee benefit plans. 

Notwithstanding any provision of this Release to the contrary, by executing this Release, I am not releasing (i) any claims relating to
my rights under Section 8 of my Employment Agreement, (ii) any claims that cannot be waived by law, or (iii) my right of indemnification and coverage under Company directors and officers liability insurance under Section 20 of my
Employment Agreement. 
 I expressly acknowledge and agree that I – 

• Am able to read the language, and understand the meaning and effect, of this Release; 

• Have no physical or mental impairment of any kind that has interfered with my ability to read and understand the meaning
of this Release or its terms, and that I am not acting under the influence of any medication, drug, or chemical of any type in entering into this Release; 

• Am specifically agreeing to the terms of the release contained in this Release because the Company has agreed to pay me
the Severance Benefits in consideration for my agreement to accept it in full settlement of all possible claims I might have or ever have had, and because of my execution of this Release; 

• Acknowledge that, but for my execution of this Release, I would not be entitled to the Severance Benefits; 

• Understand that, by entering into this Release, I do not waive rights or claims under the ADEA that may arise after the
date I execute this Release; 
 • Had or could have had [twenty-one
(21)][forty-five (45)]1 calendar days from the date of my termination of employment (the “Release Expiration Date”) in which to review and consider this Release, and
that if I execute this Release prior to the Release Expiration Date, I have voluntarily and knowingly waived the remainder of the review period; 

• Have not relied upon any representation or statement not set forth in this Release or my Employment Agreement made by
the Company or any of its representatives; 
  

	1 	To be selected based on whether applicable termination was “in connection with an exit incentive or other employment termination program” (as such phrase is defined in the Age Discrimination in Employment Act
of 1967). 

  
 B-2 

 • Was advised to consult with my attorney regarding the terms and effect of
this Release; and 
 • Have signed this Release knowingly and voluntarily. 

I represent and warrant that I have not previously filed, and to the maximum extent permitted by law agree that I will not file, a complaint,
charge, or lawsuit against any member of the Group regarding any of the claims released herein. If, notwithstanding this representation and warranty, I have filed or file such a complaint, charge, or lawsuit, I agree that I shall cause such
complaint, charge, or lawsuit to be dismissed with prejudice and shall pay any and all costs required in obtaining dismissal of such complaint, charge, or lawsuit, including without limitation the attorneys’ fees of any member of the Group
against whom I have filed such a complaint, charge, or lawsuit. This paragraph shall not apply, however, to a claim of age discrimination under the ADEA or to any non-waivable right to file a charge with the
United States Equal Employment Opportunity Commission (the “EEOC”) or similar state agency; provided, however, that if the EEOC or similar state agency were to pursue any claims relating to my employment
with the Company, I agree that I shall not be entitled to recover any monetary damages or any other remedies or benefits as a result and that this Release and Section 8 of my Employment Agreement will control as the exclusive remedy and full
settlement of all such claims by me. 
 I hereby agree to waive any and all claims to re-employment
with the Company or any other member of the Group and affirmatively agree not to seek further employment with the Company or any other member of the Group. I acknowledge that if I re-apply for or seek
employment with the Company or any other member of the Group, the Company’s or any other member of the Group’s refusal to hire me based on this provision will provide a complete defense to any claims arising from my attempt to apply for
employment. 
 Notwithstanding anything contained herein to the contrary, this Release will not become effective or enforceable prior to the
expiration of the period of seven (7) calendar days immediately following the date of its execution by me (the “Revocation Period”), during which time I may revoke my acceptance of this Release by notifying the
Company and the Board of Directors of the Company, in writing, delivered to the Company at its principal executive office, marked for the attention of its Chairman of the Board. To be effective, such revocation must be received by the Company no
later than 11:59 p.m. Eastern Time on the seventh (7th) calendar day following the execution of this Release. Provided that this Release is executed and I do not revoke it during the
Revocation Period, the eighth (8th) calendar day following the date on which this Release is executed shall be its effective date. I acknowledge and agree that if I revoke this Release during the
Revocation Period, this Release will be null and void and of no effect, and neither the Company nor any other member of the Group will have any obligations to pay me the Severance Benefits. 

The provisions of this Release shall be binding upon my heirs, executors, administrators, legal personal representatives, and assigns. If any
provision of this Release shall be held by any court of competent jurisdiction to be illegal, void, or unenforceable, such provision shall be of no force or effect. The illegality or unenforceability of such provision, however, shall have no effect
upon and shall not impair the enforceability of any other provision of this Release. 

  
 B-3 

 THIS RELEASE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF
DELAWARE, APPLICABLE TO AGREEMENTS MADE AND TO BE PERFORMED IN THAT STATE, WITHOUT REGARD TO CONFLICT OF LAWS RULES. ANY DISPUTE, CONTROVERSY OR CLAIM BETWEEN ME AND THE COMPANY ARISING OUT OF OR RELATED TO THIS RELEASE SHALL BE RESOLVED BY
ARBITRATION ADMINISTERED BY THE AMERICAN ARBITRATION ASSOCIATION (“AAA”) IN ACCORDANCE WITH ITS EMPLOYMENT ARBITRATION RULES INCLUDING THE EMERGENCY INTERIM RELIEF PROCEDURES OF THE AAA. JUDGMENT ON THE AWARD RENDERED BY THE
ARBITRATOR(S) MAY BE ENTERED IN ANY COURT HAVING JURISDICTION THEREOF. THE PLACE OF ARBITRATION SHALL BE WILMINGTON, DELEWARE. THE ARBITRATOR(S) MAY GRANT INJUNCTIONS OR OTHER RELIEF IN SUCH DISPUTE OR CONTROVERSY. THE DECISION OF THE ARBITRATOR(S)
SHALL BE FINAL, CONCLUSIVE AND BINDING ON THE PARTIES TO THE ARBITRATION. EXCEPT AS SPECIFICALLY SET FORTH HEREIN, THE COMPANY AND I SHALL EACH BEAR OUR OWN ATTORNEYS’ FEES INCURRED IN CONNECTION WITH THE ARBITRATION, AND THE ARBITRATOR(S) WILL
NOT HAVE AUTHORITY TO BE ENTITLED TO AWARD ATTORNEYS’ FEES UNLESS A STATUTE OR CONTRACT AT ISSUE IN THE DISPUTE AUTHORIZES THE AWARD OF ATTORNEYS’ FEES TO THE PREVAILING PARTY, IN WHICH CASE THE ARBITRATOR(S) SHALL HAVE THE AUTHORITY TO
MAKE AN AWARD OF ATTORNEYS’ FEES AS REQUIRED OR PERMITTED BY APPLICABLE LAW. IF THERE IS A DISPUTE AS TO WHETHER THE COMPANY IS OR I AM THE PREVAILING PARTY IN THE ARBITRATION, THE ARBITRATOR(S) WILL DECIDE THIS ISSUE. LIABILITY FOR THE FEES
AND EXPENSES OF ALL THE ARBITRATORS WITH RESPECT TO THE ARBITRATION SHALL BE EVENLY DIVIDED BETWEEN THE PARTIES TO THE ARBITRATION. THE DETERMINATION RENDERED BY THE ARBITRATOR(S) SHALL (I) SPECIFY THE FINDING OF FACTS UPON WHICH IT IS BASED
AND THE REASONS THEREFOR, AND (II) BE CONCLUSIVE AND BINDING UPON THE PARTIES. NOTWITHSTANDING THE PROVISIONS OF THIS PARAGRAPH, I HEREBY AGREE TO SUBMIT ANY AND ALL CLAIMS I MAY HAVE AGAINST THE COMPANY ON AN INDIVIDUAL BASIS. THIS MEANS THAT
NO CLAIM (INCLUDING ANY CLAIM RELATED TO TERMS OR CONDITIONS OF MY EMPLOYMENT WITH OR COMPENSATION PAID BY THE COMPANY, OR ANY CHANGE IN OR TERMINATION OF MY EMPLOYMENT) MAY BE LITIGATED OR ARBITRATED ON A CLASS OR COLLECTIVE BASIS. I ALSO HEREBY
WAIVE ANY RIGHT TO SUBMIT, INITIATE, OR PARTICIPATE IN A REPRESENTATIVE CAPACITY OR AS A PLAINTIFF, CLAIMANT, OR MEMBER IN A CLASS ACTION, COLLECTIVE ACTION, OR OTHER REPRESENTATIVE OR JOINT ACTION AGAINST THE COMPANY, REGARDLESS OF WHETHER THE
ACTION IS FILED IN ARBITRATION OR IN A JUDICIAL OR ADMINISTRATIVE FORUM. FURTHERMORE, IF A COURT ORDERS THAT A CLASS, COLLECTIVE, OR OTHER REPRESENTATIVE OR JOINT ACTION SHOULD PROCEED, IN NO EVENT WILL SUCH ACTION PROCEED IN AN ARBITRATION FORUM.
CLAIMS MAY NOT BE JOINED OR CONSOLIDATED IN ARBITRATION WITH DISPUTES BROUGHT BY ANY OTHER INDIVIDUAL(S), UNLESS AGREED TO IN WRITING BY ALL PARTIES. 

  
 B-4 

 Capitalized terms used, but not defined herein, shall have the meanings ascribed to such terms in
my Employment Agreement. 

*            *           
 * 
 I, Daniel Mark Wechsler, have executed this Release of Claims on the date set forth below: 

 

	
	  
 Daniel Mark Wechsler

	
	
	Date: [To Be Executed Following
	Termination of Employment]

  
 B-5

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