Document:

Exhibit 10.2

 

	
  SUBCONTRACT MODIFICATION

  	
  Page
  1 of 1

  
	
  1.
  SUBCONTRACTOR SERVICE AGREEMENT NO.:

  	
  2.
  EFFECTIVE DATE:

  	
  3.
  MODIFICATION NUMBER:

  	
  4.
  MODIFICATION DATE:

  
	
  DPSC02-02257

  	
  5/12/2003

  	
  03

  	
  5/22/2003

  
	
  5.  CONTRACTOR NAME AND ADDRESS:

  	
  6.  SUBCONTRACTOR NAME AND ADDRESS:

  
	
  DynPort Vaccine Company LLC

  64
  Thomas Johnson Drive

  Frederick,
  MD 21702

  	
  AVANT Immunotherapeutics, Inc.

  119 Fourth Avenue

  Needham,
  MA 02494-2725

  
	
   

  	
   

  
	
  Representatives:

  	
  Representatives:

  
	
  Contractual:

  Telephone:

  Technical:

  Telephone:

  	
  Mr. Roy Conley

  301-607-5012

  Dr. Barbara Solow

  301-607-5241

  	
  Contractual:

  Telephone:

  Technical:

  Telephone:

  	
  Mr. Chip Catlin

  781-433-3148

  Dr. Kevin Killeen

  781-433-0771

  
	
  7a.
  SUBCONTRACT MODIFICATION VALUE:

  	
   

  	
  8a.
  REFERENCE DOCUMENTS:

  
	
   

  	
   

  	
  Prime Contract No.
  DAMD17-98-C-8024

  
	
   

  	
   

  	
  Current Value

  	
   

  	
  Increase/Decrease

  	
   

  	
  Total Value

  	
   

  	
   

  	
   

  
	
  Labor

  	
   

  	
  $

  	
  2,308,450.62

  	
   

  	
  $

  	
  1,030,911.36

  	
   

  	
  $

  	
  3,339,361.98

  	
   

  	
  8b. DPAS
  RATING:

  	
   

  
	
  Other Direct Costs

  	
   

  	
  $

  	
  158,877.00

  	
   

  	
  $

  	
  223,480.36

  	
   

  	
  $

  	
  382,357.36

  	
   

  	
  DO-C9

  	
   

  
	
  Total

  	
   

  	
  $

  	
  2,467,327.62

  	
   

  	
  $

  	
  1,254,391.72

  	
   

  	
  $

  	
  3,721,719.34

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  7b.
  REVISED SUBCONTRACT AUTHORIZED FUNDED VALUE:

     

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Prior Funded Value

  	
   

  	
  Increase/Decrease

  	
   

  	
  Revised Funded Value

  	
   

  	
   

  
	
  9a.
  AGREEMENT PERIOD OF PERFORMANCE:

  
	
   

  	
   

  	
  $

  	
  2,467,327.62

  	
   

  	
  $

  	
  1,254,391.72

  	
   

  	
  $

  	
  3,721,719.34

  	
   

  	
  FROM:          12/31/2002

  	
  TO:                 8/30/2004

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  9b.
  AGREEMENT TYPE:

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  Time & Materials

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  9c.
  MODIFICATION PERIOD OF PERFORMANCE:

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  FROM:          5/12/2003

  	
  TO:                 8/30/2004

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  10. This is a

  	
  o
  ADMINISTRATIVE CHANGE

  	
       ý CHANGE ORDER

  	
  o SUPPLEMENTAL
  AGREEMENT

  
	
  11. DESCRIPTION OF MODIFICATION:

  
	
  Modification
  No. 3 to Subcontractor Service Agreement No. DPSC02-02257 is hereby issued
  to:

  
	
  1.
  Attachment A, Statement of Work, is incorporated herein.

  
	
  2.
  Attachment B, Price Schedule, is incorporated herein.

  
	
  3.
  Attachment C, Performance Schedule, is incorporated herein.

  
	
  4. Charges incurred under and authorized by this
  Subcontract Modification shall be charged against the following Contract Work
  Breakdown Structure (CWBS) numbers as appropriate, which shall be referenced
  on all project invoices and documentation:

  
	
  CWBS No. C.5.9.3.1:
  Establish Mouse and Rabbit Models for Assessing Immunogenicity of Live
  Bacterial Vector Vaccines

  
	
  CWBS No. C.5.9.3.2:
  Establish Mouse Models for Immunogenicity Ttesting of Antigen+Alhydrogel

  
	
  CWBS No. C.5.9.3.3:
  Screen and Select Optimal Live Bacterial Vector Vaccine Candidates

  
	
  CWBS No. C.5.9.3.4:
  Demonstrate the Immunogenicity of Live Bacterial Vector Vaccines in Mice

  
	
  CWBS No. C.5.9.3.5:
  Vaccination Studies in New Zealand White Rabbits

  
	
  CWBS No. C.5.9.3.6: Project
  Management

  
	
  5.
  All other terms and conditions of Subcontractor Service Agreement No.
  DPSC02-02257 remain unchanged and in full force and effect.

  
	
   

  
	
  Except as provided herein, all
  terms and conditions of the document referenced in Block No. 1 remain unchanged
  and in full force and effect.

  
	
  12.
  SUBCONTRACTOR:

  	
   

  	
  oIS NOT

  	
  ýIS

  	
  REQUIRED
  TO SIGN THIS DOCUMENT AND RETURN TWO COPIES TO THE ISSUING OFFICE.

  
	
  13. SUBCONTRACTOR: AVANT Immunotherapeutics, Inc.

  	
  14. DynPort Vaccine Company LLC:

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  /s/
  Avery W. Catlin       May 23, 2003

  	
   

  	
   

  	
  /s/
  Roy Conley       May 27, 2003

  	
   

  
	
   

  	
  (Signature of Authorized
  Company Representative) & Date

  	
   

  	
   

  	
  (Signature of Authorized
  Company Representative) & Date

  	
   

  
	
   

  	
   

  
	
  15. NAME & TITLE OF AUTHORIZED COMPANY REPRESENTATIVE:

  	
  16. NAME & TITLE OF AUTHORIZED COMPANY REPRESENTATIVE:

  
	
  (Type or Print)

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  Avery W. Catlin, Senior
  Vice President and Chief Financial Officer

  	
   

  	
  Roy Conley, Senior Manager, Subcontracts

  
	
   

  	
   

  
	
   

  	
   

  
																												

 

1Exhibit 10.3

 

	
  DynPort
  Vaccine Company LLC

  	
   

  	
  Subcontractor Service Agreement No. DPSC03-02246

  

 

SUBCONTRACT NO. DPSC03-02246

 

This is a Time and Materials (T&M)
subcontract (hereinafter referred to as “Subcontract”) by and between DynPort
Vaccine Company LLC (hereinafter referred to as “DVC”), a Virginia corporation,
and AVANT Immunotherapeutics, Inc. (hereinafter referred to as
“Subcontractor”), hereinafter referred to jointly as  “the Parties”.

 

Whereas, Subcontractor is, by reason of
knowledge, education, and/or experience, capable of performing and desires to
perform services for DVC in support of the U.S. Department of Defense Joint
Vaccine Acquisition Program (JVAP) under U.S. Government Contract No.
DAMD17-98-C-8024.

 

In consideration of the promises, mutual
covenants, and agreements contained herein, the parties agree as follows:

 

1.                                      General Terms and Conditions

The general conditions set forth in
Attachment A, General Terms and Conditions, are incorporated herein.

 

2.                                      Scope of Work

Subject to the terms and conditions of this
Subcontract, the Subcontractor will furnish the services described in
Attachment B, Statement of Work.

 

3.                                      Term

This Subcontract shall be effective for the
period July 1, 2002 through June 30, 2003. 
DVC may immediately terminate in the event of the Subcontractor’s breach
of this Subcontract, or if DVC’s prime contractual support for the
Subcontractor is terminated.  DVC
reserves the right to extend the term of this Subcontract upon written notification
to, and mutual agreement of, the Subcontractor.

 

4.                                      Authorized Funding

a.               This Subcontract has an not-to-exceed
authorized funded value of $334,257.83, in accordance with Attachment C, Price
Schedule.  This value represents the
maximum amount the Subcontractor is currently authorized to expend in
performance of the work authorized hereunder.

b.              Subcontractor shall notify DVC’s
Subcontract Administrator, in writing, if Subcontractor believes that the costs
which will become due to Subcontractor in the next sixty (60) days, when added
to all other costs previously accrued, will exceed seventy-five percent (75%)
of the authorized funding.  That notice
shall include an estimate of additional funds required.  Subcontractor is not obligated to perform
any work, and DVC is not obligated to reimburse Subcontractor for any work
performed, if in performing that work Subcontractor exceeds the authorized
funding.

c.               DVC reserves the right to change the
authorized funded value of this Subcontract if such change is deemed necessary
by DVC to ensure the fairness and reasonableness of the authorized funded value
of this Subcontract.

d.              As required, the authorized funded value
of this Subcontract will be changed by issuance of bilateral modification(s) to
this Subcontract.  The authorized funded
value of this Subcontract shall not exceed the maximum subcontract value
(ceiling value).

 

 

5.                                      Maximum Subcontract Value (Ceiling Value)

The maximum not-to-exceed value of this Subcontract (ceiling value)
shall not exceed $334,257.83.  If
Subcontractor, at any time during the performance of the work authorized
hereunder, has reason to believe that the ceiling value specified herein will
be insufficient to complete the work, Subcontractor shall notify DVC
immediately, advising the reason(s) for such cost increase and providing a
revised cost estimate with supporting cost justification.  The ceiling value indicated herein shall not
be exceeded without DVC’s prior written approval.

 

6.                                      Direction

The Subcontractor shall be responsible for
its performance. The DVC Senior Scientist, Dr. Barbara Solow, shall provide
technical direction and clarification regarding the scope of work.  The DVC Subcontract Administrator, Roy
Conley, is solely responsible for changes/modifications to the scope, schedule,
and budget of this Subcontract.  No
employment relationship between DVC and Subcontractor or its employees,
subcontractors, or agents shall be created by this Subcontract.

 

7.                                      Consideration and Payment

a.               As consideration for services to be provided
hereunder, DVC will compensate Subcontractor per Attachment C, Price Schedule.

b.              All invoices shall be signed and dated by
the Subcontractor and must reference this Subcontract number and the following
Contract Work Breakdown Structure (CWBS) number:

•                  CWBS No.
C.5.5.4.5.3.1: Stability Testing

c.               Invoices shall be due and payable within
thirty (30) days after receipt of an acceptable invoice and certification of
the labor hours worked and purchases made. 
Invoices shall be submitted, in duplicate, to:

 

	
  DynPort Vaccine Company LLC

  
	
  Attn.: Accounts Payable

  
	
  64 Thomas Johnson Drive

  
	
  Frederick, MD 21702

  
	
  Telephone:

  	
  (301) 607-5000

  
	
  Fax:

  	
  (301) 607-5068

  

 

Such invoice shall, at a minimum, include the
following information and provide the information shown on Exhibit 1, Sample
T&M Invoice:

 

•                  Subcontractor’s name and business address;

•                  Date of invoice;

•                  Period covered by invoice;

•                  This Subcontract number;

•                  Applicable CWBS number;

•                  Total number of hours worked rate per hour,
total labor charges, and total of all labor charges;

•                  Documentation to support the number of
invoiced labor hours;

•                  Charges for authorized materials, services,
or travel;

•                  Documentation to support the prices of
invoiced materials, services, or travel; and

•                  Subcontractor’s signature.

 

2

 

d.              Invoices shall be signed by a company
officer or other responsible, authorized person and contain the following
certification: “I certify to the best of my knowledge and belief that the above
request for payment is true and correct; that the charges are fair and
reasonable; and that the proposed request includes only allowable and allocable
charges.”

e.               Subcontractor will use its best efforts to
include charges on invoices no later than sixty (60) days after occurrence.

f.                 All invoices are subject to audit by the
Government for completeness and accuracy and for allowability of costs pursuant
to Federal Acquisition Regulation (FAR) Part 31.  DVC will pay only those costs ultimately determined to be
allowable.

g.              Subcontractor shall provide with its
invoices backup documentation supporting the accuracy of all invoiced non-labor
Other Direct Costs (ODCs).  This
documentation may include, but is not necessarily limited to, vendor invoices,
vendor payment registers, etc.

 

8.                                      Allowable
Charges

Payment to the
Subcontractor for the performance of services hereunder shall be as follows:

a.               DVC shall compensate the Subcontractor
for authorized work performed to address the technical intent of the Statement
of Work herein, at the T&M authorized funding specified above.

 

9.                                      Security
Requirements

The Subcontractor may be required to certify
that it has read and shall comply with all applicable project security
requirements and that the Subcontractor has received the security clearance
required for performance of the work authorized by this Subcontract.  If applicable, such security clearance shall
remain in effect during the term of this Agreement and FAR Clause 52.204-2,
Security Requirement, shall be incorporated into this Subcontract by reference.  Such certification shall be documented on a
Training Certification issued to, and executed by, the Subcontractor before
work is initiated.

 

10.                               Subcontract Supersedence

At DVC’s discretion, this Subcontract may be
superseded in its entirety by a Task Order to be issued following execution of
a Basic Ordering Agreement (BOA) between DVC and Subcontractor.

 

11.                               Defense Priorities and Allocations System (DPAS) Rating

This Subcontract is assigned a DPAS rating of
DO-C9 and contains rated order quantities certified for national defense
use.  The Subcontractor is required to
follow all of the provisions of the Defense Priorities and Allocations System
regulation (15 CFR Part 700) only as it pertains to the rated quantities.

 

12.                               Flowdown Clauses

a.               The clauses in
Attachment D, FAR and Defense Federal Acquisition Regulation Supplement (DFARS)
Flowdown Clauses, are incorporated herein by reference.

b.              Throughout this Subcontract, wherever the
following words are used in FAR/DFARS references, substitute the following:

 

	
  Government
  Term

  	
   

  	
  Substitute

  
	
  Contract

  	
   

  	
  Agreement

  
	
  Contractor

  	
   

  	
  Subcontractor

  
	
  Subcontractor

  	
   

  	
  Lower-tier Subcontractor

  
	
  Government

  	
   

  	
  DynPort Vaccine Company LLC

  
	
  Contracting Officer

  	
   

  	
  DynPort Vaccine Company LLC
  Subcontract Representative or designee

  
	
  COTR

  	
   

  	
  DynPort Vaccine Company LLC
  Technical Representative or designee

  

 

3

 

13.                               FAR/DFARS Clauses Incorporated in Full Text

The
following FAR/DFARS clauses are incorporated herein in full text:

 

52.203-11                Certification and
Disclosure Regarding Payments to Influence Certain Federal Transactions (APR
1991)

(a)          The definitions and prohibitions contained
in the clause, at FAR 52.203-12, Limitation on Payments to Influence Certain
Federal Transactions, included in this solicitation, are hereby incorporated by
reference in paragraph (b) of this certification.

(b)         The offeror, by signing its offer, hereby
certifies to the best of his or her knowledge and belief that on or after
December 23, 1989 –

(1)          No Federal appropriated funds have been paid
or will be paid to any person for influencing or attempting to influence an
officer or employee of any agency, a Member of Congress, an officer or employee
of Congress, or an employee of a Member of Congress on his or her behalf in
connection with the awarding of any Federal contract, the making of any Federal
grant, the making of any Federal loan, the entering into of any cooperative
agreement, and the extension, continuation, renewal, amendment or modification
of any Federal contract, grant, loan, or cooperative agreement;

(2)          If any funds other than Federal appropriated
funds (including profit or fee received under a covered Federal transaction)
have been paid, or will be paid, to any person for influencing or attempting to
influence an officer or employee of any agency, a Member of Congress, an
officer or employee of Congress, or an employee of a Member of Congress on his
or her behalf in connection with this solicitation, the offeror shall complete
and submit, with its offer, OMB standard form LLL, Disclosure of Lobbying
Activities, to the Contracting Officer; and

(3)          He or she will include the language of this
certification in all subcontract awards at any tier and require that all
recipients of subcontract awards in excess of $100,000 shall certify and
disclose accordingly.

(c)          Submission of this certification and
disclosure is a prerequisite for making or entering into this contract imposed
by section 1352, title 31, United States Code. Any person who makes an
expenditure prohibited under this provision or who fails to file or amend the
disclosure form to be filed or amended by this provision shall be subject to a
civil penalty of not less than $10,000, and not more than $100,000, for each
such failure.

(End of clause)

 

 

14.                               Subcontract Changes

In
accordance with Clause No. 5, Changes, of Attachment A - DVC General Terms and
Conditions, DVC may modify this Subcontract as required to accommodate scope,
schedule, and cost changes that may arise following its execution.

 

IN WITNESS HEREOF, the parties have caused
this Subcontract to be executed.

 

	
  Accepted for:

  	
   

  	
  Accepted for:

  
	
  Subcontractor

  	
   

  	
  DynPort Vaccine Company LLC

  
	
   

  	
   

  	
   

  
	
  Name:

  	
  Avery W.
  Catlin

  	
   

  	
  Name:

  	
  Roy
  Conley

  
	
   

  	
   

  	
   

  
	
  Signature:

  	
  /s/ Avery
  W. Catlin

  	
   

  	
  Signature:

  	
  /s/ Roy
  Conley

  
	
   

  	
   

  	
   

  
	
  Title:

  	
  Senior
  Vice President and CFO

  	
   

  	
  Title:

  	
  Senior
  Manager, Subc.

  
	
   

  	
   

  	
   

  
	
  Date:

  	
  May 22,
  2003

  	
   

  	
  Date:

  	
  May 27,
  2003

  
								

 

4

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