Document:

FIRST LEASE AMENDMENT TO LEASE AGREEMENT

 Exhibit 10.2(b) 
  
 NORTH CAROLINA 
  
 FIRST LEASE AMENDMENT 
  
 FORSYTH COUNTY 
  
 This First Lease Amendment (“Amendment”), made effective as of the 1st day
of January, 2005 (the “Amendment Date”), by and between Wake Forest University Health Sciences, a North Carolina non-profit corporation having its principal office in Winston-Salem, North Carolina, (“Landlord”); and Targacept,
Inc., a Delaware corporation, having its principal office in Winston-Salem, North Carolina (“Tenant”) amends that Lease entered into between the parties effective August 1, 2002 (the “Lease”). 
  
 WITNESSETH: 
  
 WHEREAS, Landlord and Tenant desire to amend the Lease upon the terms and conditions and for the rents reserved as further set forth herein,

  
 NOW, THEREFORE, Landlord and Tenant hereby agree as follows: 
  

	1.	Unless otherwise agreed herein, all of the capitalized terms of this Amendment shall have the same meanings ascribed to them in the Lease. 

  

	2.	That the Lease is amended in the following respects: 

  

	 	A.	By deleting Exhibit A of the Lease and substituting in lieu thereof the attached Exhibit A, which adds an additional 1000 rentable square feet of space from the first floor of the
Building to the Demised Premises. 

  

	 	B.	By deleting paragraph 1.2 of the Lease and renumbering paragraph 1.3 as paragraph 1.2. 

  

	 	C.	By deleting paragraph 2.3 of the Lease and substituting in lieu thereof the following: 

  

	 	“2.3	Landlord hereby grants Tenant the following options to lease additional space in the building (each, an “Option to Lease”): 

  

	 	2.3.1	  First Floor Option 

  
 Landlord hereby grants to Tenant the option to lease up to 12,338 additional rentable square feet of space on the first floor of the building (the
“First Floor Option Space”), provided Tenant shall have paid to Landlord on or before January 1, 2005 (the “Amendment Date”) the sum of $37,014 ($3.00 per rsf) as a “space hold fee” to secure this right for the period
from the Amendment 

 
Date through March 31, 2006 (the “First Floor Option Period”). Tenant will exercise this Option to Lease, if it elects exercise, by giving written
notice to Landlord not later than 60 days prior to Tenant’s intended occupancy date for such First Floor Option Space (the “First Floor Occupancy Effective Date”). Exercise of this Option to Lease shall effect a lease of the First
Floor Option Space from the First Floor Occupancy Effective Date through the balance of the Initial Term and, only if Targacept elects both to exercise the Renewal Option and to continue to lease the First Floor Option Space during the Renewal Term,
for the Renewal Term. If the Option to Lease the First Floor Option Space is exercised, (a) the First Floor Option Space shall thereupon become part of the Demised Premises for the Initial Term and, subject to the conditions set forth in the
preceding sentence, the Renewal Term and (b) Tenant will pay Rent for such First Floor Option Space during the Initial Term and, subject to the conditions set forth in the preceding sentence, the Renewal Term as set forth in paragraphs 3.1 and 3.2;
provided that (i) an amount equal to (A) $2,467.60 (the space hold fee divided by the 15 months in the First Floor Option Period) times (B) the number of calendar months for which the first day occurs after the date on which Targacept exercises the
Option to Lease the First Floor Option Space and before March 31, 2006 shall be applied as a credit against the first Rent due for the First Floor Option Space and (ii) the space hold fee is nonrefundable in the event Tenant declines to exercise the
Option to Lease the First Floor Option Space. 
  

	 	2.3.2	  PTRP Option 

  
 Landlord hereby grants to Tenant the option to lease that 4387 rentable square feet of “PTRP Space” on the first floor of the building as
designated on the attached Exhibit A-2 (the “PTRP Option Space”), the exercise of such Option to Lease being conditional on Tenant’s exercise of the Renewal Option. Tenant will exercise this Option to Lease, if it elects exercise, by
giving written notice to Landlord not less than 180 days prior to Tenant’s intended occupancy date for such space (the “PTRP Occupancy Effective Date”); provided that in no event shall the PTRP Occupancy Effective Date be prior to
July 31, 2007. Unless Landlord otherwise agrees, Tenant may exercise this Option to Lease only with respect to all of the PTRP Option Space. Exercise of this Option to Lease shall effect a lease of the PTRP Option Space from the PTRP Occupancy
Effective Date through the balance of the Renewal Term and the PTRP Option Space shall thereupon become part of the Demised Premises. Tenant will pay 

  

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Rent for such PTRP Option Space during the Renewal Term as set forth in paragraphs 3.1 and 3.2. 
  

	 	2.3.3	  Second Floor Option 

  
 Landlord hereby grants to Tenant the option to lease an additional 20,669 rentable square feet of space, being all of the second floor of the Building
(the “Second Floor Option Space”), the exercise of such Option to Lease being conditional on Tenant’s exercise of the Renewal Option. Tenant will exercise this Option to Lease, if it elects exercise, by giving written notice to
Landlord not less than twelve (12) months prior to Tenant’s intended occupancy of such space (the “Second Floor Occupancy Effective Date”); provided that in no event shall the Second Floor Occupancy Effective Date be prior to July 31,
2007. Unless Landlord otherwise agrees, Tenant may exercise this Option to Lease only with respect to all of the Second Floor Option Space. Exercise of this Option to Lease shall effect a lease of the Second Floor Option Space from the Second Floor
Occupancy Effective Date through the balance of the Renewal Term and the Second Floor Option Space shall thereupon become part of the Demised Premises. Tenant will pay Rent for such Second Floor Option Space during the Renewal Term as set forth in
paragraphs 3.1 and 3.2.” 
  

	 	D.	By deleting clause “b” of the third sentence of paragraph 2.4, and substituting the following in lieu thereof: 

  
 “b) upon Tenant’s request pursuant to paragraph 6.1 to require
Landlord to provide Tenant an allowance for redecorating or for upfitting of the Demised Premises, and continuing for the remainder of the Renewal Term; and” 
  

	 	E.	By deleting paragraph 3.1 of the Lease and substituting the following in lieu thereof: 

  

	 	“3.1	Tenant will pay annual rental pursuant to the following schedule (“rsf” indicates “rentable square foot”): 

  

													
	Term

	  	 Effective Date

	  	Demised Premises

	 	  	 	  	 40,432 rsf
 3rd & 4th Floors

	  	1000 rsf First Floor

	  	1st Floor Option
Space

	 	1st Floor PTRP
Space

	 	Second Floor Space

	Initial Term	  	 Commencement Date
 8-1-02
	  	36.00/rsf	  	—	  	—	 	—	 	—
							
	 	  	 Amendment Date
 1-1-05
	  	—	  	15.00/rsf	  	—	 	—	 	—
							
	 	  	First Floor Occupancy Effective Date	  	—	  	—	  	15.00/rsf*	 	—	 	—
							
	Renewal Term	  	8-1-2007	  	33.60/rsf	  	15.00/rsf	  	15.00/rsf*	 	—	 	—
							
	 	  	 PTRP Occupancy
 Effective Date
	  	—	  	—	  	—	 	15.00/rsf*	 	—
							
	 	  	Second Floor Occupancy Effective Date	  	—	  	—	  	—	 	—	 	15.00/rsf*

  
 *if corresponding option is exercised

  

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 (herein collectively “Rent”). Rent is payable in equal monthly installments, in advance on the
first day of each calendar month of each calendar year during the Initial Term and, if applicable, the Renewal Term, prorated for any partial month. Any increases or decreases in the amount of square footage leased during a month will be adjusted in
the subsequent monthly payment. Rent payments shall be payable to “Wake Forest University Health Sciences” and sent to Landlord in care of Controller’s Office, Attention: Doug Lischke, Medical Center Boulevard, Winston-Salem, NC,
27157.” 
  

	 	F.	By deleting the first sentence of paragraph 4.1 of the Lease and substituting the following in lieu thereof: 

  
 “Tenant shall have the right, subject to the Landlord’s
obligations to existing tenants, to the exclusive use (without payment of any additional rent) of a pro rata share of the underground parking available for the Building based on Tenant’s rentable square footage; such spaces shall be designated
for use by Tenant and are, as of the Commencement Date (and subject to increase upon exercise of any one or more of the Options to Lease set forth in paragraph 2.3), as shown on attached Exhibit A-2.” 
  

	 	G.	By deleting paragraph 6 of the Lease and substituting the following in lieu thereof: 

  

	 	6.	Upfitting/Condition of Demised Premises 

  

	 	6.1	Except as otherwise set forth herein, Tenant accepts the Demised Premises in their present condition, which condition includes certain upfitting and improvements to the third and
fourth floors made by Landlord at its cost and expense and to Tenant’s specifications prior to the Commencement Date and in accordance with that prior lease agreement between the parties dated April 20, 2001. At any time during the second year
of the Renewal Term, Landlord will provide Tenant, upon Tenant’s request, an allowance of Ten Dollars ($10.00) per rentable square foot of the third and fourth floors of the Demised Premises for use by Tenant in redecoration of such floors of
the Demised Premises. 

  

	 	6.2	 On or before the Amendment Date, Landlord shall have installed at its cost and expense a door, ceiling grid with lights, and one electrical outlet in the 1000
rentable square feet of space from the 

  

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first floor of the Building added to the Demised Premises as of the Amendment Date. 

  

	 	6.3	Upon Tenant’s exercise of the Option to Lease the First Floor Option Space, Landlord will at its cost and expense install up to four card readers and repair carpet and patch
and paint as necessary. 

  

	 	6.4	Upon Tenant’s exercise of the Option to Lease the PTRP Option Space, Landlord will at its cost and expense install two card readers and a door at the hallway off the main
lobby. 

  

	 	6.5	Upon Tenant’s exercise of the Option to Lease the Second Floor Option Space, Landlord will provide Tenant, upon Tenant’s request, an allowance of Ten Dollars ($10.00) per
rentable square foot of leased Second Floor Space as an upfit allowance for such Second Floor Space. 

  

	3.	Except as amended herein, all of the terms and conditions of the Lease shall remain in full force and effect. 

  
 IN WITNESS WHEREOF, Landlord and Tenant have caused this Amendment to be
executed, pursuant to authority duly granted, effective as of the Amendment Date set forth above. 
  

			
	LANDLORD:	 	TENANT:
		
	Wake Forest University Health Sciences	 	Targacept, Inc.
		
	By:    /s/    Richard H. Dean, M.D.	 	By:    /s/    J. Donald deBethizy
	          Richard H. Dean, M.D.	 	          J. Donald deBethizy
	          President	 	          President
		
	Date: January 6, 2005	 	Date: January 4, 2005

	

  
  

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 Exhibit A 
  
 Demised Premises 
  
 The Demised Premises consists of the following: 
  

	 	•	 	As of the Commencement Date, all of the third and fourth floors, consisting of 40,432 rentable square feet, including within the meaning of “Premises” or “Demised
Premises” the entire fourth floor of the Building, to be utilized as Tenant’s laboratory facilities, encompassing 20,216 rentable square feet, and 20,216 rentable square feet of general office space on the third floor.

  

	 	•	 	As of the Amendment Date, an additional 1,000 rentable square feet on the first floor of the Building, to be utilized as “Tenant’s Storage Space,”

  
 together with rights of use of and subject to the rights of
others in and to the Common Areas of the Building. Diagrams of the Demised Premises and Common Areas (such Common Areas designated in blue and in yellow) are as shown on the attached Exhibit A-2.LOAN AGREEMENT BETWEEN THE COMPANY AND THE CITY OF WINSTON SALEM

 Exhibit 10.3 
  
 LOAN AGREEMENT 
  
 This Loan Agreement (“Agreement”), dated as of the 19th day of April, 2002, is made and entered into between TARGACEPT, INC., a Delaware corporation (“Borrower”), and the CITY OF WINSTON-SALEM, a
municipal corporation of North Carolina (“Lender”). 
  
 RECITALS: 
  
 WHEREAS, Borrower has requested that
Lender make available to Borrower a loan in the principal amount of $500,000 (the “Loan”) on the terms and conditions hereinafter set forth; and 
  
 WHEREAS, in order to induce Lender to make the Loan to Borrower, Borrower has made certain representations to Lender; and

  
 WHEREAS, Lender, in reliance upon the representations of
Borrower, has agreed to make the Loan upon the terms and conditions hereinafter set forth; 
  
 NOW, THEREFORE, in consideration of the agreement of Lender to make the Loan, the mutual covenants and agreements hereinafter set forth, and other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, Borrower and Lender hereby agree as follows: 
  
 ARTICLE I  
 LOAN 
  
 1.1 Description of Loan. The Loan shall be evidenced by a Note (the “Note”) dated as of the date hereof (the “Issue
Date”) in the amount of Five Hundred Thousand and No/100 Dollars ($500,000). The Loan shall be payable over a term of one hundred and twenty (120) months. The date that one hundred and twenty (120) months from the date hereof is referred to
herein as the “Maturity Date.” Except as provided in Section 4.2, the Loan shall bear no interest from the Issue Date until the date that is sixty (60) months from the Issue Date (the “Anniversary Date”). Except as
provided in Section 4.2, from the Anniversary Date until the Maturity Date, the Loan shall bear interest during each fiscal year based on Borrower’s Gross Revenues during Borrower’s preceding fiscal year as follows: 
  

					
	 Period

	  	 Gross Revenues for Preceding Fiscal Year

	  	Applicable Interest Rate
Per Annum

	Anniversary Date - December 31, 2007	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%

					
	January 1, 2008-December 31,2008	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2009-December 31,2009	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2010-December 31,2010	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2011-December 31, 2011	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%
			
	January 1, 2012-Maturity Date	  	Greater than or equal to $100,000,000	  	7%
	  	Less than $100,000,000	  	5%

  
 For example, the applicable interest
rate per annum for the period beginning on the Anniversary Date and ending on December 31, 2007 shall be either 7% if Borrower’s Gross Revenues during the fiscal year ending December 31, 2006 are greater than or equal to $100,000,000, or 5% if
Borrower’s Gross Revenues during the fiscal year ending December 31, 2006 are less than $100,000,000. The applicable interest rate per annum for the period beginning on January 1, 2008 and ending on December 31,2008 shall be either 7% if
Borrower’s Gross Revenues for the fiscal year ending December 31, 2007 are greater than or equal to $100,000,000, or 5% if Borrower’s Gross Revenues during the fiscal year ending December 31, 2007 are less than $100,000,000. Gross Revenues
shall mean total sales of Borrower before any deductions for expenses or costs. The applicable interest rate shall be determined based on an officer’s certificate delivered annually by Borrower in accordance with Section 3.2 and shall be
adjusted as of the first day of the year following the fiscal year as to which the officer’s certificate relates; provided, however, that if Borrower fails to provide any officer’s certificate to Lender as required 

  

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by and within the time limits set forth in Section 3.2, the applicable interest rate from January 1 of such year until an appropriate officer’s
certificate is provided shall be seven percent (7%). 
  
 No payment of principal
or interest shall be due until the Anniversary Date. Beginning on the Anniversary Date and continuing on a monthly basis, Borrower shall pay to Lender monthly installments of principal and interest in the amount of Nine Thousand Four Hundred
Thirty-Five and 63/100 Dollars ($9,435.63), with all remaining principal and unpaid interest payable on the Maturity Date. Upon an Event of Default, the amount of unpaid principal and interest and all other sums due under this Loan Agreement shall
bear interest at the rate of sixteen percent (16%) per annum after default until paid. Interest on the Loan shall be computed on the basis of a 360-day year of twelve 30-day months. The Loan may be prepaid in full or in part at any time without
penalty or premium. 
  
 ARTICLE II 
 WARRANTIES 
  
 Borrower hereby warrants to Lender as follows: 
  
 2.1 Corporate Status. Borrower is a corporation duly organized, validly existing, and in good standing under the laws of the state of Delaware and
has the corporate power to own and operate its properties, to carry on its business as now conducted, and to enter into and to perform its obligations under this Agreement and the Note. 
  
 2.2 Authorization. Except as disclosed on Schedule 2.2, Borrower has full legal right, power, and authority to
enter into and perform its obligations under this Agreement and the Note, without the consent or approval of any other person, firm, governmental agency, or other legal entity. The execution and delivery of this Agreement, the borrowing hereunder,
the execution and delivery of the Note, and the performance by Borrower of its obligations hereunder and thereunder are within its corporate powers and have been duly authorized by all necessary corporate action properly taken, have received all
necessary governmental approvals, and do not and will not contravene or conflict with any material provision of law, any material applicable judgment, ordinance, regulation, or order of any court or governmental agency, the charter or bylaws of
Borrower, or any material agreement binding upon it or its properties. 
  
 2.3 Validity and Binding Effect. This Agreement and the Note are the legal, valid, and binding obligations of Borrower, enforceable in accordance with their terms. 
  
 2.4 No Consent Required. Except as disclosed on Schedule 2.4, the execution, delivery, and performance of this
Agreement and the Note by Borrower do not require the consent or approval of or the giving of notice to any person or entity other than the approval of the Board of Directors of Borrower. 
  
 2.5 Solvency. Borrower is solvent as of the date of this Agreement. For purposes of this Section 2.5,
“solvent” shall mean Borrower (i) is able to pay its debts as they mature, and (ii) owns assets having present fair saleable value greater than the amount required to pay its debts. 
  

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 2.6 Survival. The representations and warranties of Borrower contained in this Agreement shall
survive until this Agreement terminates in accordance with Article V hereof. 
  
 ARTICLE III 
 COVENANTS AND AGREEMENTS 
  
 3.1 Payment of Indebtedness. Borrower shall pay the indebtedness evidenced by the Note according to the terms
thereof. 
  
 3.2 Financial Reports. Until this Agreement
terminates in accordance with Article V hereof, Borrower will furnish to Lender within one hundred twenty (120) days after the close of each fiscal year of Borrower a certificate, executed by the chief financial officer, controller, or treasurer of
Borrower, setting forth the true and correct amount of Gross Revenues of Borrower for such fiscal year. 
  
 3.3 No Relocation. Until this Agreement terminates in accordance with Articles V hereof, Borrower agrees not to relocate outside of the City of
Winston-Salem (i) its principal place of business; (ii) any material portion of its primary operations, including, but not limited to, its research and technology, manufacturing, or administrative divisions, or (iii) any material number of its
employees with respect to any division of Borrower. 
  
 3.4
Notice of Default. Until this Agreement terminates in accordance with Article V hereof, Borrower shall give written notice to Lender of the occurrence of any Event of Default (as defined below) under this Agreement or the Note of which
Borrower becomes aware promptly upon the occurrence thereof. 
  
 ARTICLE IV 
 DEFAULT AND REMEDIES 
  
 4.1 Events of Default. The occurrence of any of the following shall constitute an Event of Default hereunder: 
  
 (a) Default in the payment of the principal of or interest
on the indebtedness evidenced by the Note in accordance with the terms of the Note; 
  
 (b) Any material misrepresentation by Borrower as to any matter hereunder; 
  
 (c) Failure of Borrower to perform any of its obligations under this Agreement; 
  
 (d) Borrower’s (i) admission in writing of its
inability to pay its debts generally as they become due; (ii) assignment for the benefit of creditors or petition or application to any tribunal for the appointment of a custodian, receiver, or trustee for it or a substantial part of its assets; or
(iii) voluntary commencement of any proceeding under any 

  

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bankruptcy, reorganization, arrangement, readjustment of debt, dissolution, or liquidation law or statute of any jurisdiction, whether now or hereafter in
effect, or the involuntary commencement of any such proceeding that is not dismissed within sixty (60) days; 
  
 (e) Borrower ceases to do business or sells all or substantially all of its assets or properties; or 
  
 (f) Borrower’s liquidation or dissolution; 

 
 provided, however, that with respect to any default described above that is capable of
being cured, the occurrence of such default shall not constitute an Event of Default hereunder if such default is fully cured and corrected within thirty (30) days (ten (10) days, if such default may be cured by payment of a sum of money) of notice
thereof to Borrower. 
  
 4.2 Acceleration of Maturity. Upon
the occurrence of any Event of Default described in Section 4.1, the indebtedness evidenced by the Note shall be immediately due and payable in full. In addition, if the Event of Default is caused by a breach by Borrower of its covenants contained
in Section 3.3, Borrower agrees that the indebtedness immediately due and payable shall include all unpaid principal and interest computed as if the interest payable pursuant to the Note beginning on the Issue Date and continuing over the term of
the Note were seven percent (7%). 
  
 4.3 Remedies Cumulative;
No Waiver. No right, power, or remedy conferred upon or reserved to Lender by this Agreement or the Note is intended to be exclusive of any other right, power, or remedy, but each and every such right, power, and remedy shall be cumulative and
concurrent and shall be in addition to any other right, power, and remedy given hereunder or under the Note or now or hereafter existing at law, in equity, or by statute. No delay or omission by Lender to exercise any right, power, or remedy
accruing upon the occurrence of any Event of Default shall exhaust or impair any such right, power, or remedy or shall be construed to be a waiver of any such Event of Default or an acquiescence therein, and every right, power, and remedy given by
this Agreement and the Note to Lender may be exercised from time to time and as often as may be deemed expedient by Lender. 
  
 ARTICLE V  
 TERMINATION

  
 This Agreement shall remain in full force and effect until the
repayment in full of the Note. 
  
 ARTICLE VI 
 MISCELLANEOUS 
  
 6.1 Successors and Assigns. The Agreement shall inure to the benefit of the successors and permitted assigns of the parties hereto. 
  

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 6.2 Assignment. Neither this Agreement nor the Note may be assigned by Borrower without the prior
written consent of Lender. 
  
 6.3 Time of the Essence.
Time is of the essence with respect to each and every covenant, agreement, and obligation of Borrower and Lender hereunder and under the Note. 
  
 6.4 Severability. If any provision of this Agreement or the application thereof to any person or circumstance shall be invalid or unenforceable to
any extent, the remainder of this Agreement and the application of such provisions to other persons or circumstances shall not be affected thereby and shall be enforced to the greatest extent permitted by law. 
  
 6.5 Notices. All notices and other communications hereunder shall be
deemed given if given in writing and delivered personally, by courier or by facsimile transmission, or mailed by registered or certified mail (return receipt requested), courier, facsimile, or postage fees prepaid, to the party to receive the same
at its address set forth below (or at such other address as may from time to time be designated by such party to the other in accordance with this Section 6.5): 
  
 If to Lender: 
  
 The City of Winston-Salem 
 P.O. Box 2511

 Winston-Salem, NC 27102 
 Telephone: 336-727-8040 
 Attention: Derwick L. Paige 
  
 If to Borrower: 
  
 Targacept, Inc. 
 200 East First Street, Suite
300 
 Winston-Salem, NC 27101 
 Telephone: 336-480-2186 
 Facsimile: 336-480-2112 
 Attention: Alan A. Musso, Vice President and Chief Financial Officer 
  
 6.6 Entire Agreement. This Agreement and the Note represent the entire agreement between the parties concerning the subject matter hereof.

  
 6.7 Governing Law. This Agreement shall be construed
and enforced under the laws of the State of North Carolina without regard to the conflicts of laws thereunder. 
  
 6.8 Counterparts. This Agreement may be executed in multiple originals or counterparts, each of which shall be deemed an original and all or which
when taken together shall constitute but one and the same instrument. 
  
 6.9 Amendments. No amendment or modification hereof shall be effective except in a writing executed by each of the parties hereto. 
  

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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above
written. 
  

			
	 BORROWER:

	
	 TARGACEPT, INC.

		
	By:	 	 /s/ Alan A. Musso

	 Name:
	 	 Alan A. Musso

	 Title:
	 	 Chief Financial Officer

  

			
	 LENDER:

	
	 CITY OF WINSTON-SALEM

		
	By:	 	 /s/ Derwick L. Paige

	 Name:
	 	 Derwick L. Paige

	 Title:
	 	 Development Director

  

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