Document:

Amendment to Purchase Agreement

 EXHIBIT 4.2 
 Execution Version 
 FIRST AMENDMENT TO THE 

PURCHASE AGREEMENT 
 July 20, 2011 
 This First Amendment to the Purchase Agreement (the “First
Amendment”) is dated as of the date hereof, between Icagen, Inc., a Delaware corporation with offices at 4222 Emperor Boulevard, Suite 350, Durham, North Carolina 27703 (“Icagen”), and Pfizer Inc., a Delaware corporation
with offices at 235 East 42nd Street, New York, New York 10017 (“Pfizer”). 
 Capitalized terms used but not
otherwise defined herein shall have the same meaning ascribed to such terms in the Merger Agreement (as defined below). 

WHEREAS, Pfizer and Icagen entered into a Purchase Agreement (the “Purchase Agreement”) as of August 13, 2007, whereby
Pfizer agreed to purchase from Icagen, and Icagen agreed to issue and sell to Pfizer, upon the terms and conditions stated in the Purchase Agreement, up to a maximum of $15,000,000 of Icagen’s common stock, par value $0.001 per share (the
“Common Stock”); 
 WHEREAS, on August 20, 2007, in a first closing under the Purchase Agreement, Icagen
sold shares of Common Stock with an aggregate purchase price of approximately $15,000,000 to Pfizer and in a subsequent closing under the Purchase Agreement on February 13, 2008, Icagen sold shares of Common Stock to Pfizer with an aggregate
purchase price of approximately $10,000,000; 
 WHEREAS, under Section 3.6 of the Purchase Agreement, Pfizer agreed to appoint,
subject to certain exceptions, each of the President and the Treasurer of Icagen, with full power of substitution, as the proxies of Pfizer with respect to certain matters on which Pfizer is entitled to vote as a holder of Common Stock; 

WHEREAS, concurrently with the execution and delivery of this First Amendment, Icagen, Pfizer and Eclipse Acquisition Corp., a Delaware
corporation and a direct or indirect wholly-owned subsidiary of Pfizer, are entering into an Agreement and Plan of Merger, dated as of the date hereof (the “Merger Agreement”); and 

WHEREAS, the parties hereto desire to amend the Purchase Agreement as set forth herein. 

NOW, THEREFORE, in consideration of the mutual covenants contained herein, and for other good and valuable consideration, the parties
hereto, intending to be legally bound, hereby agree as follows: 
  

	1.	Proxy 

  

	 	1.1.	The parties agree that, effective upon the execution of this First Amendment, and notwithstanding any provision in the Purchase Agreement to the contrary, Pfizer shall
be permitted to vote, or cause to be voted, and Pfizer hereby agrees to vote, 

  
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or cause to be voted, all of the Shares then beneficially owned by Pfizer or any of its subsidiaries (including Sub) in favor of the Merger and the adoption of the Merger Agreement.

  

	 	1.2.	The parties further agree that, from and after the Acceptance Time, and notwithstanding any provision in the Purchase Agreement to the contrary, Pfizer shall be
permitted to vote or cause to be voted, all of the Shares then beneficially owned by Pfizer or any of its subsidiaries (including Sub) for such directors on Icagen’s board of directors as are designated by Pfizer pursuant to Section 6.10 of the
Merger Agreement. 

  

	2.	Miscellaneous 

  

	 	2.1.	If for any reason the Merger Agreement is terminated, this First Amendment shall automatically terminate and be of no further force or effect. 

 

	 	2.2.	The parties hereby confirm and agree that, as amended hereby, the Purchase Agreement, including all other terms and conditions, remains in full force and effect and is
a binding obligation of the parties hereto. 

  

	 	2.3.	This First Amendment may be executed in two or more counterparts, by facsimile or other electronic format, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. 

 [Signature page follows] 

  
 2 

 IN WITNESS WHEREOF, the parties have caused this First Amendment to be duly executed as of
the date first above written. 
  

			
	ICAGEN, INC.
		
	By:	 	/s/ P. Kay Wagoner, Ph.D.
	Name:	 	P. Kay Wagoner, Ph.D.
	Title:	 	President and Chief Executive Officer

  

			
	PFIZER INC.
		
	By:	 	/s/ Douglas E. Giordano
	Name:	 	Douglas E. Giordano
	Title:	 	Senior Vice President
Worldwide Business Development

 FIRST AMENDMENT TO PURCHASE
AGREEMENTAmendment to Collaborative Research and Licence Agreement

 EXHIBIT 10.1 
 THIRD AGREEMENT AND AMENDMENT TO THE 
 COLLABORATIVE RESEARCH &
LICENSE AGREEMENT 
 July 20, 2011 
 This Third Agreement and Amendment to the Collaborative Research & License Agreement (the “Third Amendment”) is dated as of the date hereof, between Icagen, Inc., a Delaware
corporation with offices at 4222 Emperor Boulevard, Suite 350, Durham, North Carolina 27703 (“Icagen”), and Pfizer Inc., a Delaware corporation with offices at 235 East 42nd Street, New York, New York 10017
(“Pfizer”). 
 Capitalized terms used but not otherwise defined herein shall have the same meaning ascribed to
such terms in the Amended Collaborative Agreement (as defined below). 
 WHEREAS, Pfizer and Icagen entered into the
Collaborative Research & License Agreement (the “Collaborative Agreement”) as of August 13, 2007, and subsequently entered into (i) an Agreement and Amendment to the Collaborative Agreement as of September 17, 2009 (the
“First Amendment”), and (ii) a Second Agreement and Amendment to the Collaborative Agreement as of September 21, 2010 (the “Second Amendment,” together with the Collaborative Agreement and the First Amendment, the
“Amended Collaborative Agreement”); 
 WHEREAS, under Section 4.4 of the Amended Collaborative Agreement,
Pfizer has agreed to pay Icagen certain development milestone payments upon the completion of certain Development Events (such payments, the “Development Milestone Payments”); 

WHEREAS, concurrently with the execution and delivery of this Third Amendment, Icagen, Pfizer and Eclipse Acquisition Corp., a Delaware
corporation and a direct or indirect wholly-owned subsidiary of Pfizer, are entering into an Agreement and Plan of Merger, dated as of the date hereof (the “Merger Agreement”); and 

WHEREAS, the parties hereto desire to amend the Amended Collaborative Agreement as set forth herein. 

NOW, THEREFORE, in consideration of the mutual covenants contained herein, and for other good and valuable consideration, the parties
hereto, intending to be legally bound, hereby agree as follows: 
  

	1.	Development Milestone Payments 

  

	 	1.1	The parties agree that, from and after the date of this Third Amendment, no Development Milestone Payments shall be due or payable by Pfizer to Icagen, nor shall Pfizer
be required to notify Icagen of the achievement of any Development Event, in each case, under Section 4.4 of the Amended Collaborative Agreement, provided that, if the Merger Agreement is terminated pursuant to Section 8.1 of the Merger Agreement,
then this Section 1.1 of this Third Amendment shall terminate and all Development Milestone Payment obligations and notification obligations with respect to the achievement of Development Events shall 

	 	
thereupon be reinstated (a “Reinstatement”). 

  

	 	1.2	Upon a Reinstatement, any Development Milestone Payment(s) that would have been due and payable by Pfizer to Icagen but for this Third Amendment, shall be paid by
Pfizer in accordance with the terms of the Amended Collaborative Agreement with interest from the date such payment would have been payable without regard to this Third Amendment (the “Interest Start Date”) until the date paid at a
rate equal to the prime rate of Citibank, NA as announced on the Interest Start Date plus three percent (3%), compounded on a calendar quarterly basis. Except as provided in Section 2.1, this Section 1.2 shall survive any expiration or termination
of the Amended Collaborative Agreement. 

  

	 	1.3	A termination of the Amended Collaborative Agreement prior to the date of any termination of the Merger Agreement shall not relieve Pfizer of an obligation to make a
Development Milestone Payment under Section 10.4 of the Amended Collaborative Agreement, as reinstated pursuant to a Reinstatement, following the termination of the Merger Agreement, if such Development Milestone Payment would otherwise have been
due and payable without regard to this Third Amendment. 

  

	 	1.4	Pfizer shall notify Icagen within ten (10) days after a Reinstatement of any Development Events that were completed prior to such Reinstatement and not previously
reported to Icagen. 

  

	 	1.5	Pfizer shall not set-off any obligation or liability of Icagen pursuant to the Merger Agreement or any related agreement against any payment obligation of Pfizer under
the Amended Collaborative Agreement or Section 1.2 of this Third Amendment. 

  

	2.	Termination 

  

	 	2.1.	At the Effective Time (as defined in the Merger Agreement), the Amended Collaborative Agreement shall be terminated without further obligation or liability (for any
Development Milestone Payments or otherwise) thereunder on the part of any party hereto. 

  

	3.	Miscellaneous 

  

	 	3.1.	The parties hereby confirm and agree that, as amended hereby, the Amended Collaborative Agreement, including all other terms and conditions, remains in full force and
effect and is a binding obligation of the parties hereto. 

  

	 	3.2.	This Third Amendment may be executed in two or more counterparts, by facsimile or other electronic format, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. 

 [Signature page follows] 

 IN WITNESS WHEREOF, the parties have caused this Third Amendment to be duly executed as of
the date first above written. 
  

			
	ICAGEN, INC.
		
	By:	 	 /s/ P. Kay Wagoner, Ph.D.

	Name:	 	P. Kay Wagoner, Ph.D.
	Title:	 	President and Chief Executive Officer
	
	PFIZER INC.
		
	By:	 	 /s/ Douglas E. Giordano

	Name:	 	Douglas E. Giordano
	Title:	 	Senior Vice President
Worldwide Business Development

 THIRD AGREEMENT AND AMENDMENT
TO COLLABORATIVE AGREEMENT

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