Document:

Fourth Amendment to Sublease, dated as of October 12, 2007

 Exhibit 10.52 
 FOURTH AMENDMENT TO SUBLEASE 
 THIS FOURTH AMENDMENT
TO SUBLEASE (this “Fourth Amendment”), dated October 12, 2007, is entered into by and between DIADEXUS,
INC., a Delaware corporation (“Sublandlord”), and MONOGRAM BIOSCIENCES, INC., a Delaware corporation (“Subtenant”). 
 RECITALS 
 A.
Sublandlord and Subtenant entered into that certain Sublease dated June 1, 2002 (the “Original Sublease”), as amended by that certain First Amendment to Sublease dated August 21, 2003, that certain Second
Amendment to Sublease dated October 1, 2004 and that certain Third Amendment dated August 18, 2006 (together with the Original Sublease, the “Sublease”), pursuant to which Sublandlord subleased to Subtenant, and
Subtenant subleased from Sublandlord, certain Sublease Premises in a building located at 343 Oyster Point Boulevard, South San Francisco, California. 
 B. Capitalized terms not otherwise defined herein are used as defined in the Sublease. 
 C.
Sublandlord and Subtenant desire to amend the Sublease as set forth herein. 
 NOW, THEREFORE, in
consideration of the mutual covenants and conditions contained herein, Sublandlord and Subtenant covenant and agree as follows: 
 AGREEMENT 
 1. Term. The sublease for the Section A, Section B Space and expanded premises as
defined in the third sublease shall not expire on December 31, 2007 and shall be extended to continue in full force and effect May 20, 2011, unless sooner terminated pursuant to any provision of the Sublease. 
 2. Rent. Base Rent per month effective January 1, 2008 will be as follows: 
  

				
	 January 1, 2008 – December 31, 2008:
	  	$	77,342
	 January 1, 2009 – December 31, 2009:
	  	$	79,662
	 January 1, 2010 – December 31, 2010:
	  	$	82,052
	 January 1, 2011 – May 20, 2011:
	  	$	84,514

 3. Broker. Each party hereto represents and warrants that it has dealt with no
brokers in connection with this Fourth Amendment, and shall indemnify, protect, defend and hold the other harmless from all costs and expenses (including reasonable attorneys’ fees) arising from a breach of the foregoing representation and
warranty. 
 4. Full Force and Effect. Except as expressly amended hereby, the Sublease remains in full force and effect.

  

 1 

 5. Counterparts. This Fourth Amendment may be executed in counterparts, each of which shall
be an original, but all of which shall constitute a single agreement. 
 6. Effectiveness. This Fourth Amendment shall not be
effective until signed by Master Landlord in the space set forth for that purpose below. 
 IN WITNESS
WHEREOF, the parties here caused this Fourth Amendment to be duly executed by their respective authorized officers as of the date first written above. 
  

									
	SUBLANDLORD:	 		 	DIADEXUS, INC.,
		 		 	a Delaware corporation
					
		 		 		 	By:	 	/s/ David Foster
		 		 		 	Name:	 	David Foster
		 		 		 	Its:	 	EVP & CFO
			
	SUBTENANT:	 		 	MONOGRAM BIOSCIENCES, INC.,
		 		 	a Delaware corporation
					
		 		 		 	By:	 	/s/ Alfred Merriweather
		 		 		 	Name:	 	Alfred Merriweather
		 		 		 	Its:	 	CFO

 The undersigned, Master Landlord under the Master Lease, hereby consents to the foregoing Fourth
Amendment. 
  

											
	MASTER LANDLORD:	 		 	ARE-TECHNOLOGY CENTER SSF, LLC,
		 		 	a Delaware limited liability company
				
		 		 	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P.,
 a Delaware limited partnership, Managing
 Member

					
		 		 		 	By:	 	 ARE-QS CORP., a Maryland
 corporation, General Partner

						
		 		 		 		 	By:	 	 
		 		 		 		 	Name:	 	
		 		 		 		 	Its:	 	

  

 2Consent to Fourth Sublease Amendment, dated as of October 12, 2007

 EXHIBIT 10_53 
 CONSENT TO FOURTH SUBLEASE AMENDMENT 
 This Consent to Fourth Sublease Amendment (this
“Consent”) is made as of October 12, 2007, by and among ARE-TECHNOLOGY CENTER SSF, LLC, a Delaware limited liability company (“Landlord”), DIADEXUS, INC., a Delaware corporation (“New
Tenant”), and MONOGRAM BIOSCIENCES, INC., a Delaware corporation (“Sublessee”), formerly known as VIROLOGIC, INC., with reference to the following Recitals. 
 RECITALS 
 A. Sublessee
subleases certain premises from New Tenant pursuant to the provisions of that certain Sublease dated June 1, 2002, between New Tenant and Sublessee, as amended by that certain First Amendment to Sublease dated August 21, 2003, as further
amended by that certain Second Amendment to Sublease dated October 1, 2004, and as further amended by that certain Third Amendment to Sublease dated August 18, 2006 (as amended, the “Sublease”). 
 B. Landlord consented to the Sublease pursuant to that certain Consent to Sublease dated June 1, 2002, that certain Consent to Sublease
Amendment dated September 5, 2003, that certain Consent to Second Sublease Amendment dated October 1, 2004, and that certain Consent to Third Sublease Amendment dated September 22, 2006 (collectively, the “Original
Consent”). 
 C. New Tenant and Sublessee have amended the Sublease pursuant to that certain Fourth Amendment to Sublease
dated October 12, 2007 (the “Sublease Amendment”), and desire to obtain Landlord’s approval to the Sublease Amendment. A copy of the Sublease Amendment is attached hereto as Exhibit A. 
 NOW, THEREFORE, in consideration of the foregoing and the agreements contained herein, and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, Landlord hereby consents to the Sublease Amendment, such consent being subject to and upon the following terms and conditions to which New Tenant and Sublessee hereby agree: 
  

	1.	All initially capitalized terms not otherwise defined in this Consent shall have the meanings set forth in the Original Consent unless the context clearly indicates otherwise.

  

	2.	This Consent shall not be effective and the Sublease Amendment shall not be valid unless and until Landlord shall have received: (a) a fully executed counterpart of the
Sublease Amendment, and (b) a fully executed counterpart of this Consent. 

  

	3.	Landlord neither approves nor disapproves the terms, conditions and agreements contained in the Sublease Amendment, all of which shall be subordinate and at all times subject to all
of the covenants, agreements, terms, provisions and conditions contained in the Lease and the Original Consent. 

  

	4.	Nothing contained herein or in the Sublease Amendment shall be construed to modify, waive, impair, or affect any of the terms, covenants or conditions contained in the Lease.

 

 
  

 1 

	5.	New Tenant and Sublessee reaffirm each of the terms, conditions and agreements contained in the Original Consent. 

  

	6.	This Consent may not be changed orally, but only by an agreement in writing signed by Landlord and the party against whom enforcement of any change is sought.

  

	7.	This Consent may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken together shall constitute but one and the same
instrument. 

  

	8.	This Consent and the legal relations between the parties hereto shall be governed by and construed and enforced in accordance with the internal laws of the State in which the
Premises is located, without regard to its principles of conflicts of law. 

 [Signatures on next page] 
 

 
  

 2 

 IN WITNESS WHEREOF, Landlord, New Tenant and Sublessee have caused their duly authorized
representatives to execute this Consent as of the date first above written. 
  

							
	LANDLORD:
	
	 ARE-TECHNOLOGY CENTER SSF, LLC,
 a
Delaware limited liability company

		
	By:	 	Alexandria Real Estate Equities, L.P.,
		 	a Delaware limited partnership
		 	its managing member
			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	its general partner
				
		 		 	By:	 	  

				
		 		 	Its:	 	  

	
	NEW TENANT:
	
	 DIADEXUS, INC.,
 a Delaware
corporation

		
	By:	 	 /s/ David Foster

		
	Its:	 	 EVP

	
	SUBLESSEE:
	
	 MONOGRAM BIOSCIENCES, INC.,
 a
Delaware corporation

		
	By:	 	 

		
	Its:	 	 CFO

 

 
  

 S-1 

 EXHIBIT A  
 SUBLEASE AMENDMENT 
 [Attached]Second Amendment to Credit and Security Agreement, dated as of December 19, 2007

 Exhibit 10.54 
 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS
AMENDED. 
 SECOND AMENDMENT TO CREDIT AND SECURITY AGREEMENT 
 THIS SECOND AMENDMENT TO CREDIT AND SECURITY AGREEMENT (this “Agreement”) is entered into this 19th day of December, 2007, by and
between MONOGRAM BIOSCIENCES, INC., a Delaware corporation (“Borrower”) and MERRILL LYNCH CAPITAL, a division of Merrill Lynch Business Financial Services Inc., individually as a Lender, and as Agent
(“Agent”). 
 Recitals 
 A. Agent and Borrower have entered into that certain Credit and Security Agreement dated as of September 27, 2006 (as the same may from time to time be amended, modified, supplemented or restated, the
“Credit Agreement”). Agent has extended credit to Borrower for the purposes permitted in the Credit Agreement. 
 B.
Borrower has requested that Agent amend the Credit Agreement to (i) extend the [*] and (ii) increase the letter of credit sublimit. Agent has agreed to so amend the Credit Agreement, but only to the extent, in accordance with the
terms, subject to the conditions and in reliance upon the representations and warranties set forth below. 
 Agreement 
 NOW, THEREFORE, in consideration of the foregoing recitals and other good and valuable consideration, the receipt
and adequacy of which is hereby acknowledged, and intending to be legally bound, the parties hereto agree as follows: 
 1.
Definitions. Capitalized terms used but not defined in this Agreement, including its preamble and recitals, shall have the meanings given to them in the Credit Agreement. 
 2. Amendments to Credit and Security Agreement. 
 2.1 ETag Name Change. All references in the Credit Agreement to “ETag” are hereby deleted and replaced with
“VeraTag”, due to a change by Borrower in the name of its ETag products to VeraTag. 
 2.2
Section 1.1 (Certain Defined Terms). The reference to “$700,000” in clause (h) of the definition of “Permitted Indebtedness” in Section 1.1 of the Credit Agreement is hereby amended by deleting it and
replacing it with “$1,000,000”. 

 2.3 Section 4.14 [*]. The reference to [*] in Section 4.14
of the Credit Agreement is hereby amended by deleting it and replacing it with [*] 
 3. Representations and Warranties. To
induce Agent to enter into this Agreement, Borrower hereby represents and warrants to Agent as follows: 
 3.1
Immediately after giving effect to this Agreement (a) except as set forth in the updated disclosure Schedules attached hereto as Schedule 1, the representations and warranties contained in the Financing Documents are true, accurate and
complete in all material respects as of the date hereof (except to the extent such representations and warranties relate to an earlier date, in which case they are true and correct as of such date), and (b) no Event of Default has occurred and
is continuing; 
 3.2 Borrower has the power and due authority to execute and deliver this Agreement and to perform its
obligations under the Credit Agreement; 
 3.3 The execution and delivery by Borrower of this Agreement and the
performance by Borrower of its obligations under the Credit Agreement have been duly authorized by all necessary action on the part of Borrower; 
 3.4 The organizational documents of Borrower delivered to Agent on the Closing Date remain true, accurate and complete and have not been amended, supplemented or restated and are and continue to be in full
force and effect; 
 3.5 The execution and delivery by Borrower of this Agreement and the performance by Borrower of
its obligations under the Credit Agreement do not and will not contravene (a) any law or regulation binding on or affecting Borrower, (b) any material contractual restriction with a Person binding on Borrower, (c) any order, judgment
or decree of any court or other governmental or public body or authority, or subdivision thereof, binding on Borrower, or (d) the organizational documents of Borrower; 
 3.6 The execution and delivery by Borrower of this Agreement and the performance by Borrower of its obligations under the Credit
Agreement do not require any order, consent, approval, license, authorization or validation of, or filing, recording or registration with, or exemption by any governmental or public body or authority, or subdivision thereof, binding on either
Borrower, except as already has been obtained or made; and 
 3.7 This Agreement has been duly executed and delivered
by Borrower and is the binding obligation of Borrower, enforceable against Borrower in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization, liquidation, moratorium or other similar laws
of general application and equitable principles relating to or affecting creditors’ rights. 
 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

 4. Limitation of Consent and Amendments. 
 4.1 The amendments set forth in Sections 2 and 3, above are effective for the purposes set forth herein and shall be limited
precisely as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition of any Financing Document, or (b) otherwise prejudice any right or remedy which Agent may now have or
may have in the future under or in connection with any Financing Document. 
 4.2 This Agreement shall be construed in
connection with and as part of the Financing Documents and all terms, conditions, representations, warranties, covenants and agreements set forth in the Financing Documents, except as herein amended, are hereby ratified and confirmed and shall
remain in full force and effect. 
 5. Counterparts. This Agreement may be executed in any number of counterparts and all of
such counterparts taken together shall be deemed to constitute one and the same instrument. 
 6. Effectiveness. This Agreement
shall be deemed effective upon (a) the due execution and delivery to Agent of this Agreement by each party hereto, (b) Borrower’s payment to Agent of modification fee of $20,000, and (c) Borrower’s payment of Agent’s
legal fees and expenses in connection with the negotiation and preparation of this Agreement. 
 7. Governing Law. This
Agreement and the rights and obligations of the parties hereto shall be governed by and construed in accordance with the laws of the State of Illinois. 
 8. Integration. This Agreement and the Financing Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements. All prior agreements, understandings,
and negotiations between the parties about the subject matter of this Agreement, and the Financing Documents merge into this Agreement and the Financing Documents. 
 [Signature page follows.] 
 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

 IN WITNESS WHEREOF, the parties hereto have caused
this Agreement to be duly executed and delivered as of the date first written above. 
  

			
	BORROWER:
	
	MONOGRAM BIOSCIENCES, INC.
		
	By:	 	/s/ Alfred Merriweather
		 	Name: Alfred Merriweather
		 	Title: Sr. VP and CFO

  

			
	AGENT:
	
	MERRILL LYNCH CAPITAL, a division of Merrill Lynch Business Financial Services Inc.,
as Agent and a Lender
		
	By:	 	/s/ Maurice Ansellem, VP
		 	Name: Maurice Ansellem
		 	Title: VP

 [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED
AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

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