Document:

Exhibit 10.42

August 1, 2007

Ms. Judy Brown,
Contracts Manager

Office of Research

University of Waterloo

200 University Avenue West

Waterloo, Ontario, Canada N2L 3G1

Re:                             Extension
and Amendment to Budget and Research Agreement between

Waterloo, Thompson, and Senesco for a One Year Period From

September 1, 2007 Through August 31, 2008

Dear Ms. Brown:

Pursuant to the
Research Agreement effective September 1, 1998 (the “Agreement”), copy
attached, between the University of Waterloo (“Waterloo”), Dr. John E. Thompson
(“Thompson”), and Senesco, Inc. (“Senesco”), Waterloo, Thompson and Senesco
hereby agree to extend the Agreement for an additional one year term, effective
September 1, 2007 through August 31, 2008, under the same terms and conditions
provided in the Agreement, except that the parties hereby amend the Budget set
forth in the Revised Budget for Year 9, effective September 1, 2006 to the
Revised Annual Budget for Year 10 , attached hereto, effective September 1, 2007
through August 31, 2008.  The Revised Annual
Budget for Year 10 supercedes and replaces the Revised Budget for Year 9 of the
Agreement for all work commencing on or after September 1, 2007.

	
   

  	
  Very truly yours,

  
	
   

  	
   

  
	
   

  	
  /s/ Bruce C.
  Galton

  	
   

  
	
   

  	
  Bruce C. Galton

  
	
   

  	
  President

  
	
   

  	
  Senesco, Inc.

  
	
  Agreed and
  Accepted:

  	
   

  
	
   

  	
   

  
	
  /s/ University
  of Waterloo

  	
   

  	
   

  
	
  University of
  Waterloo

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  /s/ Dr. John
  Thompson, Ph.D.

  	
   

  	
   

  
	
  Dr. John
  Thompson, Ph.D.

  	
   

  

 

REVISED
ANNUAL BUDGET

YEAR 10

PERIOD:     September
1, 2007 – August 31, 2008

	
  Salaries

  	
   

  	
  Cdn $/Month

  	
   

  	
  Cdn $/12 Months

  	
   

  
	
  Senior Research
  Associate

  ($80,000/year + 15% benefits)

  	
   

  	
  $

  	
  7,666.67

  	
   

  	
  $

  	
  92,000.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Senior Research
  Associate

  ($71,250/year + 15% benefits)

  	
   

  	
  6,833.33

  	
   

  	
  82,000.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Research Associate

  ($40,000/year + 15% benefits)

  	
   

  	
  3,833.33

  	
   

  	
  46,000.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Research Associate

  ($40,000/year + 15% benefits)

  	
   

  	
  3,833.33

  	
   

  	
  46,000.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Research Associate

  ($40,000/year + 15% benefits)

  	
   

  	
  3,833.34

  	
   

  	
  46,000.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Research Associate

  ($26,000/year + 15% benefits)

  	
   

  	
  2,500.00

  	
   

  	
  30,000.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Supplies

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Operating Expenses

  	
   

  	
  13,333.33

  	
   

  	
  160,000.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Overhead

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  30% on total direct
  costs

  	
   

  	
  12,550.00

  	
   

  	
  150,600.00

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  TOTAL ANNUAL
  BUDGET

  	
   

  	
  $

  	
  54,383,33

  	
   

  	
  $

  	
  652,600.00Exhibit 10.43

April 2, 2007

Dr. JamesW. Mier

Division of
Oncology

Beth Israel
Deaconess Medical Center

Kirstein 158

330 Brookline
Avenue

Boston, MA 02215

Re:  Agreement for Service on Senesco
Technologies, Inc. Scientific Advisory Board

Dear Dr. Mier:

This will confirm the
terms of the agreement between you and Senesco Technologies, Inc. (“SENESCO”)
concerning your service on the SENESCO Scientific Advisory Board.

You have agreed to serve
on the SENESCO Scientific Advisory Board for a three year term to begin on
April 1, 2007 and end on March 31, 2010. 
This agreement may be terminated by either party with ninety (90) days
written notice.  In this capacity, you
agree to provide consulting services relating to research and development on
genes and their cognate expressed proteins that are induced during or
coincident with the onset of cell death, which may initiate or facilitate cell
death, together with methods for controlling cell death that involve altering
the expression of these genes, along with all other SENESCO technological
developments (“Subject Matter of this Agreement”).  As a member of the SENESCO Scientific
Advisory Board, you agree to alert the company to technology and research in
the industry which is relevant to the Subject Matter of this Agreement, and to
act as a member of a forum for the exchange of new ideas.  You agree to participate in conference calls,
participate in brief conference at your offices, and review materials forwarded
to you by SENESCO (the volume of time and materials shall be reasonable in
light of your position).  As compensation
for your service, SENESCO agrees to pay you $10,000 per annum, payable in equal
quarterly installments.  In addition,
SENESCO will reimburse you for reasonable out of pocket expenses incurred by
you in connection with your services hereunder.

As a condition of your
service to SENESCO, you will agree to keep Confidential Information of SENESCO
in confidence:

a.               Confidential
Information includes all information disclosed by SENESCO to you whether said
disclosure is made in writing, by submission of samples,

orally, or otherwise, relating to the matters which
are within the scope and are the subject of this Agreement and all other
associated information regarding SENESCO’s past, present, or future research,
technology, know-how, ideas, concepts, designs, products, prototypes,
processes, machines, compositions of matter, business plans, technical
information, drawings, specifications and the like, relating in each case to
the Subject Matter of this Agreement and any knowledge or information developed
by you as a result of work in connection with this Agreement; except
information which, at the time of the disclosure to you or development under
this agreement:

(1)             is established by
written records to be in the public domain other than as a consequence of an
act by you;

(2)             was in your
possession prior to the disclosure and is demonstrated  through written record that such information
was in your possession prior to disclosure from SENESCO, and was not the
subject of an earlier confidential relationship with SENESCO; or

(3)             was rightfully
acquired by you from a third party, who was lawfully in possession of such
information after the disclosure and was under no obligation to SENESCO to
maintain its confidentiality.

b.              All Confidential
Information of SENESCO disclosed to you shall remain the sole property of
SENESCO.  You agree that the Confidential
Information will be kept in strict confidence until such Confidential
Information becomes readily and conveniently available in the trade.  You agree that you will not directly or
indirectly disclose, furnish, disseminate, make available or use the
Confidential Information except as necessary to perform the consulting services
under the provision of this Agreement. 
Your confidentiality obligations hereunder will survive the termination
of this agreement.

c.               While
you serve on the SENESCO Scientific Advisory Board, you will promptly inform
SENESCO if you discover that a third party is making or threatening to make
unauthorized use of Confidential Information.

d.              You
acknowledge that the agreements contained herein are of a special nature and
that any material breach of this Agreement by you will result in irreparable
harm or injury to SENESCO.

You represent and
warrant that you have the full power to enter into and perform this Agreement,
and that you are under no obligation or restriction and will not assume any
obligation or restriction that would in any way be considered by a reasonable
person to interfere with, be inconsistent with, or present a conflict of
interest concerning your services in connection with this Agreement.

During the period
of this Agreement, you represent and warrant that you are not rendering and
will not render any other consulting services relating to the Subject Matter of
this Agreement.

You hereby assign
and agree to assign to SENESCO all of your right, title and interest in any
inventions made, conceived of or arising as a result of your performance of
duties under this Agreement.  All
information and know-how relating to such inventions is also deemed
Confidential Information of SENESCO and shall be kept in confidence by you
pursuant to this Agreement.  SENESCO has
control of all right, title and interest to any patent or patent application
drawn to such inventions conceived of or made during the performance of your
work under this Agreement.  You shall, at
the reasonable request and expense of SENESCO, at any time during or after the
termination of this Agreement, execute all documents and perform all such acts
as SENESCO may deem necessary or advisable to confirm SENESCO’s sole and
exclusive ownership right, title and interest in such inventions in any
country.  You agree to do all acts and
execute all documents at the expense and request of SENESCO that SENESCO may
deem necessary to secure its rights to such inventions, including but not
limited to assisting in the preparation and prosecution of patent applications.

In view of the
highly confidential nature of the services to be rendered by you under this
Agreement, you hereby agree that you will not, during the period of this
Agreement, act as a consultant, or perform any other services, either directly
or indirectly, for any entity in the world which is competitive with SENESCO
relating to the Subject Matter of this Agreement.  The parties hereby agree that the period of
time and scope of the restrictions specified herein are both reasonable and
justifiable to prevent harm to the legitimate business interests of SENESCO,
including but not limited to preventing transfer of Confidential Information to
SENESCO’s competitors and/or preventing other unauthorized disclosures or use
of SENESCO’s technology and inventions.

Yours Truly,

Sascha P. Fedyszyn

Vice President, Corporate
Development

SENESCO
TECHNOLOGIES, INC.

	
  Agreed:

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