Document:

EX-4.2

 Exhibit 4.2 

$600,000,000 
 3.250%
SENIOR NOTES DUE 2024 
 LABORATORY CORPORATION OF AMERICA HOLDINGS 

as 
 Issuer 

AND 
 U.S. BANK NATIONAL
ASSOCIATION 
 as 

Trustee 
 ELEVENTH
SUPPLEMENTAL INDENTURE 
 DATED AS OF AUGUST 22, 2017 

 TABLE OF CONTENTS 

 
  

			
	 	 	 PAGE

	ARTICLE 1	 	
	RELATION TO INDENTURE; DEFINITIONS; RULES OF CONSTRUCTION	 	
		
	 Section 1.01. Scope of Supplemental Indenture
	 	1
	 Section 1.02. Relation To Indenture
	 	1
	 Section 1.03. Definitions
	 	2
	 Section 1.04. Capitalized Terms
	 	6
		
	ARTICLE 2	 	
	THE SECURITIES	 	
	 Section 2.01. Title of the Securities
	 	6
	 Section 2.02. Aggregate Principal Amount
	 	6
	 Section 2.03. Maturity Date
	 	6
	 Section 2.04. Ranking
	 	6
	 Section 2.05. Interest
	 	6
	 Section 2.06. Issuance Price
	 	6
	 Section 2.07. Defeasance
	 	7
	 Section 2.08. Form and Dating
	 	7
	 Section 2.09. Conversion
	 	7
	 Section 2.10. Guarantees
	 	7
		
	ARTICLE 3	 	
	OPTIONAL REDEMPTION	 	
		
	 Section 3.01. Optional Redemption
	 	7
	ARTICLE 4	 	
	ADDITIONAL COVENANTS	 	
		
	 Section 4.01. Limitation on Liens
	 	8
	 Section 4.02. Limitation on Sale and Leaseback Transactions
	 	9
	 Section 4.03. Limitation on Subsidiary Indebtedness and Preferred Stock
	 	10
		
	ARTICLE 5	 	
	OFFER TO REPURCHASE	 	
		
	 Section 5.01. Offer to Repurchase
	 	10
		
	ARTICLE 6	 	
	EVENTS OF DEFAULT	 	
		
	 Section 6.01. Events of Default
	 	12

  
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	 	 	 PAGE

		
	ARTICLE 7	 	
	MISCELLANEOUS	 	
		
	 Section 7.01. Successors and Assigns
	 	12
	 Section 7.02. Effectiveness
	 	12
	 Section 7.03. Ratification of Indenture
	 	12
	 Section 7.04. Governing Law
	 	12
	 Section 7.05. Multiple Originals
	 	12
	 Section 7.06. Headings
	 	12

  

  
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 ELEVENTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of
August 22, 2017 between Laboratory Corporation of America Holdings, a Delaware corporation (or its permitted successor) (the “Company”), and U.S. Bank National Association, as Trustee under the Indenture (the “Trustee”).

 W I T N E S S E T H 

WHEREAS, the Company has heretofore executed and delivered to the Trustee an indenture (the “Indenture”), dated as of
November 19, 2010; 
 WHEREAS, the Company proposes to create under the Indenture a new series of Securities in the form of senior
notes to be designated as the 3.250% Senior Notes due 2024; 
 WHEREAS, Section 2.01 of the Indenture provides that at or prior to the
issuance of any Securities within a series, the terms of the series of Securities shall be established by a supplemental indenture or an Officers’ Certificate pursuant to authority granted under resolutions of the Board of Directors of the
Company; 
 WHEREAS, the Company desires to provide for the establishment of a series of Securities under the Indenture, and the form of and
terms thereof as hereinafter set forth; and 
 WHEREAS, the Company has requested that the Trustee execute and deliver this Supplemental
Indenture and all conditions necessary to authorize the execution and delivery of this Supplemental Indenture and to make it a valid and binding agreement of the Company have been done or performed. 

NOW THEREFORE, in consideration of the foregoing and for good and valuable consideration, the receipt of which is hereby acknowledged, the
Company, and the Trustee mutually covenant and agree for the equal and ratable benefit of the Holders of the Securities as follows: 

ARTICLE 1 
 RELATION
TO INDENTURE; DEFINITIONS; RULES OF CONSTRUCTION 

Section 1.01. Scope of Supplemental Indenture. The changes, modifications and supplements to the Indenture effected by this
Supplemental Indenture shall be applicable only with respect to, and shall only govern the terms of, the Notes (as defined below) and shall not apply to any other Securities that may be issued under the Indenture unless a supplemental indenture with
respect to such other Securities specifically incorporates such changes, modifications and supplements. The provisions of this Supplemental Indenture shall supersede any corresponding provisions in the Indenture. 

Section 1.02. Relation To Indenture. This Supplemental Indenture constitutes an integral part of the Indenture. 

  
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 Section 1.03. Definitions. For all purposes of this Supplemental Indenture, the
following terms shall have the respective meanings set forth in this Section. 
 “Acquired Indebtedness” means Indebtedness of a
Person (i) existing at the time such Person becomes a Subsidiary of the Company or (ii) assumed in connection with the acquisition of assets by such Person, in each case, other than Indebtedness incurred in connection with, or in
contemplation of, such Person becoming a Subsidiary of the Company or such acquisition, as the case may be. For purposes of Section 4.03 hereof, any Acquired Indebtedness shall not be deemed to have been incurred until 270 days from the date
(A) the Person obligated on such Acquired Indebtedness becomes a Subsidiary of the Company or (B) the acquisition of assets, in connection with which such Acquired Indebtedness was assumed, is consummated. 

“Adjusted Treasury Rate” means, with respect to any redemption date, (i) the yield, under the heading which represents the
average for the immediately preceding week, appearing in, or available through, the most recently published statistical release designated “H.15” or any successor publication which is published weekly by the Board of Governors of the
Federal Reserve System (or companion online data resource published by the Board of Governors of the Federal Reserve System) and which establishes yields on actively traded United States Treasury securities adjusted to constant maturity under the
caption “Treasury Constant Maturities,” for the maturity corresponding to the Comparable Treasury Issue (if no maturity is within three months before or after the remaining term of the Notes being redeemed (assuming that the Notes matured
on the Par Call Date), yields for the two published maturities most closely corresponding to the Comparable Treasury Issue shall be determined and the Adjusted Treasury Rate shall be interpolated or extrapolated from such yields on a straight line
basis, rounding to the nearest month) or (ii) if such release (or any successor release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue (expressed as a percentage of its principal amount) assuming a price for the Comparable Treasury Issue equal to the Comparable Treasury Price for such redemption date, in each case calculated on the
third business day preceding the redemption date, plus the make-whole spread specified Section 3.01 of this Supplemental Indenture. 

“Attributable Debt” means, with respect to a Sale and Leaseback Transaction, an amount equal to the lesser of: (1) the fair
market value of the property (as determined in good faith by the Company’s Board of Directors); and (2) the present value of the total net amount of rent payments to be made under the lease during its remaining term, discounted at the rate
of interest set forth or implicit in the terms of the lease, compounded semi-annually. 
 “Below Investment Grade Rating Event”
means the Notes are rated below Investment Grade by both Rating Agencies on any date from the date of the public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the
occurrence of a Change of Control, which period shall be extended so long as the rating of the Notes is under publicly announced consideration for possible downgrade by either of the Rating Agencies. 

  
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 “Capitalized Lease” means any obligation of a Person to pay rent or other amounts
incurred with respect to real property or equipment acquired or leased by such Person and used in its business that is required to be recorded as a capital lease in accordance with GAAP; provided that, for purposes of this definition only,
“GAAP” shall mean GAAP as in effect as of the date of this Supplemental Indenture and not as in effect from time to time. 

“Change of Control” means the occurrence of any of the following: 

 

	 	(a)	the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the properties or
assets of the Company and those of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other than the Company or a Subsidiary Guarantor that is a wholly owned Subsidiary
of the Company; 

  

	 	(b)	the adoption of a plan relating to the liquidation or dissolution of the Company; 

  

	 	(c)	the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act),
other than the Company or a Subsidiary Guarantor that is a wholly-owned Subsidiary of the Company, becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the
Voting Stock of the Company, measured by voting power rather than number of shares; or 

  

	 	(d)	the first day on which a majority of the members of the Board of Directors are not Continuing Directors. 

Notwithstanding the foregoing, a transaction effected to create a holding company for the Company will not be deemed to involve a Change of
Control if (1) pursuant to such transaction the Company becomes a wholly owned Subsidiary of such holding company and (2) the holders of the Voting Stock of such holding company immediately following such transaction are the same as the
holders of the Voting Stock of the Company immediately prior to such transaction. 
 “Change of Control Repurchase Event” means
the occurrence of a Change of Control and a Below Investment Grade Rating Event. 
 “Comparable Treasury Issue” means the United
States Treasury security selected by the quotation agent as having a maturity comparable to the remaining term from the redemption date to the Par Call Date of the Notes being redeemed that would be utilized,

  
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at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of the Securities.

 “Comparable Treasury Price” means, with respect to any redemption date, if clause (ii) of the Adjusted Treasury Rate is
applicable, the average of three, or such lesser number as is obtained by the trustee, Reference Treasury Dealer quotations for such redemption date. 

“Consolidated Total Assets” means, with respect to any Person as of any date, the amount of total assets as shown on the
consolidated balance sheet of such Person for the most recent fiscal quarter for which financial statements have been filed with the Commission, prepared in accordance with GAAP. 

“Continuing Directors” means, as of any date of determination, any member of the Board of Directors who: 

 

	 	(a)	was a member of such Board of Directors on the first date that any of the Notes were issued; or 

  

	 	(b)	was nominated for election or elected to the Board of Directors with the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election.

 “Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) (or, in each case, if such Rating Agency ceases to rate the Notes for reasons outside of the Control of the Company, the
equivalent investment grade credit rating from any Rating Agency selected by the Company as a replacement Rating Agency). 

“Make-Whole Amount” means the sum, as determined by a quotation agent, of the present values of the scheduled payments of principal
and interest (exclusive of interest to the redemption date) from the redemption date to the Par Call Date, in each case discounted to the redemption date on a semi-annual basis, assuming a 360-day year consisting of twelve 30-day months, at the
Adjusted Treasury Rate. 
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s Corporation,
and its successors. 
 “Notes” means the $600,000,000 3.250% Senior Notes due 2024 whose CUSIP is 50540R AT9. 

“Par Call Date” means July 1, 2024. 

“Permitted Acquired Indebtedness” means any Acquired Indebtedness that remains outstanding following the expiration of a good faith
offer by the Company or a 

  
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Subsidiary of the Company obligated under such Acquired Indebtedness to acquire such Acquired Indebtedness, including, without limitation, an offer to exchange such Acquired Indebtedness for debt
securities for the Company, on terms, which in the opinion of an independent investment banking firm of national reputation and standing, are consistent with market practices in existence at the time for offers of a similar nature; provided that the
initial expiration date of any such offer shall be not later than the expiration of the 270-day period referred to in the definition of “Acquired Indebtedness”; provided further, that the amount of Acquired Indebtedness that shall
constitute “Permitted Acquired Indebtedness” shall only be equal to the amount of Acquired Indebtedness that the Company or such Subsidiary of the Company has made an offer to acquire in accordance with the foregoing. 

“Principal Property” means any real property and any related buildings, fixtures or other improvements located in the United States
owned by the Company or its Subsidiaries (1) that is an operating property included in the list of principal properties in Item 2 (or any successor Item thereto) of the annual report on Form 10-K of the Company filed with the Commission
for the most recently ended fiscal year, or is an operating property acquired subsequent to such filing that would have been included in such Item 2 if it had been owned prior to the date of such filing or (2) the net book value of which
as of the end of the last fiscal quarter ending immediately prior to the date of determination exceeds 1% of the Consolidated Total Assets of the Company as of the same date. 

“Rating Agency” means: 

(a) each of Moody’s and S&P; and 

(b) if either of Moody’s or S&P ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons
outside of the Control of the Company, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act selected by the Company as a replacement agency for Moody’s or S&P,
or both, as the case may be. 
 “Reference Treasury Dealer” means Citigroup Global Markets Inc. and its successors and assigns,
Merrill Lynch, Pierce, Fenner & Smith Incorporated and its successors and assigns and a primary U.S. government securities dealer selected by Wells Fargo Securities, LLC. 

“Restricted Subsidiary” means any Subsidiary of the Company that owns a Principal Property. 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and its successors.

 “Sale and Leaseback Transaction” means any arrangement with any Person providing for the leasing by the Company or any
Restricted Subsidiary of real or personal property that is to be sold or transferred by the Company or such Restricted Subsidiary to such Person or to any other Person to whom funds have been or are to be advanced by such Person on the security of
such property or rental obligations of the Company or such Restricted Subsidiary. 

  
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 “Voting Stock”, as applied to stock of any Person, means shares, interests,
participations or other equivalents in the equity interest (however designated) in such Person having ordinary voting power for the election of a majority of the directors (or the equivalent) of such Person, other than shares, interests,
participations or other equivalents having such power only by reason of the occurrence of a contingency. 
 Section 1.04.
Capitalized Terms. Capitalized terms used herein but not defined shall have the meanings assigned to them in the Indenture. 
 ARTICLE
2 
 THE SECURITIES 

There is hereby established a series of Securities pursuant to the Indenture with the following terms: 

Section 2.01. Title of the Securities. The series of Securities shall be designated the 3.250% Senior Notes due 2024 (the
“Notes”) whose CUSIP is 50540R AT9. 
 Section 2.02. Aggregate Principal Amount. The Notes shall be initially issued
in an aggregate principal amount of $600,000,000 (not including the Notes authenticated and delivered upon registration of, transfer of, or in exchange for, or in lieu of, other Notes pursuant to Sections 2.05, 2.06, 2.07, 2.08, 3.01 or 10.02 of the
Indenture) and additional Notes may be issued from time to time without notice to or consent of the Holders, provided that if the additional Notes are not fungible with the then-outstanding Notes for U.S. federal income tax purposes, the additional
Notes shall have a separate CUSIP number. 
 Section 2.03. Maturity Date. The date on which the principal, and all accrued and
unpaid interest on, the Notes is payable is September 1, 2024, subject to the provisions of the Indenture relating to acceleration. 

Section 2.04. Ranking. The Notes shall be unsecured senior debt of the Company and shall rank on a parity with all other unsecured
and unsubordinated Indebtedness of the Company. 
 Section 2.05. Interest. The Notes shall bear interest from August 22,
2017, or from the most recent Interest Payment Date to which interest has been paid or duly provided for, at a rate of 3.250% per annum, payable semi-annually on March 1 and September 1 of each year, commencing March 1, 2018. The
Company shall pay interest to the Person in whose name a Note is registered at the close of business on the February 15 or August 15, as the case may be, preceding the Interest Payment Date. The Company shall compute interest on the basis
of a 360-day year consisting of twelve 30-day months. 
 Section 2.06. Issuance Price. [Intentionally Omitted] 

  
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 Section 2.07. Defeasance. The Notes shall be subject to defeasance under
Section 10.02 of the Indenture, provided that for purposes of Sections 10.03(6) and (7) of the Indenture, the term “Securityholders” shall refer to the beneficial owners of the Notes. 

Section 2.08. Form and Dating. (a) The Notes shall be substantially in the form of Exhibit A hereto. The Notes may have
notations, legends or endorsements required by law, stock exchange rule or usage. Each Note shall be dated the date of its authentication. 

(b) The terms and provisions contained in the Notes shall constitute, and are hereby expressly made, a part of this Supplemental Indenture,
and the Company and the Trustee, by their execution and delivery of this Supplemental Indenture, expressly agree to such terms and provisions and to be bound thereby. However, to the extent any provision of any Notes conflicts with the express
provisions of this Supplemental Indenture, the provisions of this Supplemental Indenture shall govern and be controlling. 
 (c) The Notes
shall be issued in the form of fully-registered Global Securities. The Global Securities shall be deposited with, or on behalf of, the Depositary and registered in the name of the Depositary or its nominee. Except as set forth in Section 2.11
of the Indenture, the Global Securities may be transferred, in whole and not in part, only by the Depositary to its nominee or by its nominee to such Depositary or another nominee of the Depositary or by the Depositary or its nominee to a successor
of the Depositary or a nominee of such successor. In addition, the Company may at any time determine not to have the Notes represented by Global Securities, and, in such event, will issue Notes in certificated form in exchange for the Global
Securities. In either instance, an owner of an interest in the Global Securities would be entitled to physical delivery of such Notes in certificated form. Notes so issued in certificated form shall be issued in denominations of $1,000 and integral
multiples of $1,000 in excess thereof and shall be issued in registered form only. 
 Section 2.09. Conversion. The Notes shall
not be convertible into any shares of common stock of the Company or other securities of the Company. 
 Section 2.10.
Guarantees. The Notes are not guaranteed by any guarantor. 
 ARTICLE 3 

OPTIONAL REDEMPTION 

Section 3.01. Optional Redemption. Prior to July 1, 2024, the Company may redeem the Notes, in whole or in part, at any time,
or from time to time, at its option at a price equal to the greater of (1) 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest to the redemption date and (2) the Make-Whole Amount for the Notes, which
shall include a make-whole spread of 0.20%. 
 On or after July 1, 2024, the Company may redeem the Notes in whole or in part, at any
time, or from time to time, at its option, at a price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued and unpaid interest to the redemption date. 

  
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 ARTICLE 4 

ADDITIONAL COVENANTS 

Section 4.01. Limitation on Liens. So long as any Notes are outstanding, the Company shall not, and shall not permit any
Restricted Subsidiary to, create, incur, assume or suffer to exist any Lien upon any Principal Property or shares of stock or Indebtedness of any Restricted Subsidiary to secure any Indebtedness, without effectively providing that the Notes shall
(so long as such other Indebtedness shall be so secured) be equally and ratably secured. 
 The foregoing limitation shall not apply to:

 (a) Liens for taxes not yet due or that are being contested in good faith by appropriate proceedings, provided that adequate reserves
with respect thereto are maintained on the books of the Company or the books of the Restricted Subsidiaries, as the case may be, in conformity with GAAP; 

(b) carriers’, warehousemen’s, mechanics’, materialmen’s, repairmen’s or other like Liens arising in the ordinary
course of business securing obligations that are not overdue for a period of more than 90 days or that are being contested in good faith by appropriate proceedings; 

(c) pledges or deposits in connection with workers’ compensation, unemployment insurance and other social security legislation and
deposits securing liability to insurance carriers under insurance or self-insurance arrangements; 
 (d) deposits to secure the performance
of bids, trade contracts (other than for borrowed money), leases, statutory obligations, surety and appeal bonds, performance bonds and other obligations of a like nature incurred in the ordinary course of business; 

(e) easements, rights-of-way, restrictions and other similar encumbrances incurred in the ordinary course of business that, in the aggregate,
are not substantial in amount and that do not in any case materially detract from the value of the property subject thereto or materially interfere with the ordinary conduct of the business of the Company or of such Restricted Subsidiary; 

(f) Liens in existence on the first date of the issuance of the Notes; 

(g) Liens arising in connection with trade letters of credit issued for the account of the Company or the account of a Restricted Subsidiary
securing the reimbursement obligations in respect of such letters of credit, provided, that such Liens encumber only the property being acquired through payments made under such letters of credit or the documents of title and shipping and insurance
documents relating to such property; 

  
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 (h) Liens on intellectual property acquired by the Company or a Restricted Subsidiary (such as
software) securing the obligation of the Company or the obligation of such Restricted Subsidiary to make royalty or similar payments to the seller of such intellectual property, provided, that such Liens encumber only the intellectual property to
which such payments relate; 
 (i) any Lien upon any property or assets created at the time of the acquisition, purchase, lease, improvement
or development of property or assets used or held by the Company or any Restricted Subsidiary or within one year after such time to secure all or a portion of the purchase price or lease for, or the costs of improvement or development of, such
property or assets; 
 (j) any Lien upon any property or assets existing thereon at the time of the acquisition thereof (provided such Lien
was not incurred in anticipation of such acquisition) by the Company or any Restricted Subsidiary (whether or not the obligations secured thereby are assumed by the Company or any Restricted Subsidiary); 

(k) any Lien in favor of the Company or any Restricted Subsidiary; 

(l) Liens in respect of judgments that do not constitute an Event of Default; 

(m) Liens to secure any extension, renewal, refinancing or refunding (or successive extensions, renewals, refinancings or refundings), in
whole or in part, of any Indebtedness secured by Liens referred to in the foregoing clauses (f) through (l) or Liens created in connection with any amendment, consent or waiver relating to such Indebtedness, so long as such Lien does not extend to
any other property and the Indebtedness so secured does not exceed the fair market value (as determined by the Board of Directors) of the assets subject to such Liens at the time of such extension, renewal, refinancing or refunding, or such
amendment, consent or waiver, as the case may be; or 
 (n) any Lien securing any Indebtedness in an amount which, together with, without
duplication, (i) all other Indebtedness secured by a Lien that is not otherwise permitted by the foregoing provisions, (ii) the Attributable Debt of any Sale and Leaseback Transaction that is not otherwise permitted under clauses (a)
through (d) in Section 4.02, and (iii) any Indebtedness incurred by a Subsidiary of the Company pursuant to clause (c) in Section 4.03 does not at the time of the incurrence of the Indebtedness so secured exceed 5% of the Consolidated
Total Assets of the Company. 
 Section 4.02. Limitation on Sale and Leaseback Transactions. So long as any Notes are
outstanding, the Company shall not, and shall not permit any Restricted Subsidiary to, enter into any Sale and Leaseback Transaction with respect to any Principal Property unless: 

(a) the Sale and Leaseback Transaction involves a lease for a term of not more than five years; 

  
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 (b) the Sale and Leaseback Transaction is between the Company and a Subsidiary Guarantor or
between Subsidiary Guarantors; 
 (c) the Company or a Restricted Subsidiary would be entitled to incur Indebtedness secured by a Lien on
such property or assets involved in such Sale and Leaseback Transaction without equally and ratably securing the Notes pursuant to Section 4.01; 

(d) the cash proceeds of such Sale and Leaseback Transaction are at least equal to the fair market value thereof or the debt attributable
thereto and the Company applies an amount equal to the greater of the net proceeds of such sale or the Attributable Debt with respect to such Sale and Leaseback Transaction within 270 days of such sale to either (or a combination) of (x) the
retirement (other than the mandatory retirement, mandatory prepayment or sinking fund payment or by payment at maturity) of the long-term debt of the Company or the long-term debt of a Restricted Subsidiary (other than long-term debt that is
subordinated to the Notes) or (y) the acquisition, purchase, improvement or development of other comparable property, including the acquisition of other businesses; or 

(e) the Attributable Debt of the Sale and Leaseback Transaction is in an amount which, together with, without duplication, (i) all of the
Attributable Debt of the Company and its Restricted Subsidiaries under this clause (e), (ii) all other Indebtedness secured by a Lien that is not otherwise permitted by the provisions of clauses (a) through (m) pursuant to Section 4.01, and
(iii) any Indebtedness incurred by a Subsidiary of the Company pursuant to clause (c) in Section 4.03 does not at the time of such transaction exceed 5% of the Consolidated Total Assets of the Company. 

Section 4.03. Limitation on Subsidiary Indebtedness and Preferred Stock. So long as any Notes are outstanding, the Company shall
not cause or permit its direct or indirect Subsidiaries to incur, create, issue, assume or permit to exist any Indebtedness or Preferred Stock (other than Permitted Indebtedness) unless the amount of such Indebtedness or Preferred Stock, when taken
together with, without duplication, (a) all other Indebtedness (other than Permitted Indebtedness) incurred pursuant to this Section 4.03, (b) all other Indebtedness secured by a Lien that is not otherwise permitted by the provisions
of clauses (a) through (m) in Section 4.01, and (c) the Attributable Debt of any Sale and Leaseback Transaction that is not otherwise permitted by the provisions of clauses (a) through (d) in Section 4.02, does not at the time of the incurrence
exceed the greater of (i) $750.0 million and (ii) 5% of the Consolidated Total Assets of the Company. 
 ARTICLE 5 

OFFER TO REPURCHASE 

Section 5.01. Offer to Repurchase. If a Change of Control Repurchase Event occurs, unless the Company has exercised its
right to redeem the Notes as described in Section 3.01, the Company shall make an offer to each Holder of Notes to repurchase all or any part (in multiples of $1,000 principal amount) of that Holder’s Notes at a

  
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repurchase price in cash equal to 101% of the aggregate principal amount of Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to the date of purchase. Within 30 days
following any Change of Control Repurchase Event or, at the option of the Company, prior to any Change of Control, but after the public announcement of the Change of Control, the Company will mail a notice to each Holder describing the transaction
or transactions that constitute or may constitute the Change of Control Repurchase Event and offer to repurchase Notes on the payment date specified in the notice, which date shall be no earlier than 30 days and no later than 60 days from the date
such notice is mailed. The notice shall, if mailed prior to the date of consummation of the Change of Control, state that the offer to purchase is conditioned on the Change of Control Repurchase Event occurring on or prior to the payment date
specified in the notice. The Company shall comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the
repurchase of the Notes as a result of a Change of Control Repurchase Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control Repurchase Event provisions of the Notes, the Company will
comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control Repurchase Event provisions of the Notes by virtue of such conflict. 

On the Change of Control Repurchase Event payment date, the Company shall, to the extent lawful: 

(a) accept for payment all Notes or portions of Notes properly tendered pursuant to its offer; 

(b) deposit with the Paying Agent an amount equal to the aggregate purchase price in respect of all Notes or portions of Notes properly
tendered; and 
 (c) deliver or cause to be delivered to the Trustee the Notes properly accepted, together with an Officers’
Certificate stating the aggregate principal amount of Notes being purchased by the Company. 
 The Paying Agent will promptly mail to each
Holder of Notes properly tendered the purchase price for the Notes, and the Trustee will promptly authenticate and mail (or cause to be transferred by book-entry) to each Holder a new note equal in principal amount to any unpurchased portion of any
Notes surrendered; provided that each new note will be in a principal amount of $1,000 or an integral multiple of $1,000 in excess thereof. 

The Company shall not be required to make an offer to repurchase the Notes upon a Change of Control Repurchase Event if a third party makes an
offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and such third party purchases all Notes properly tendered and not withdrawn under its offer. 

  
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 ARTICLE 6 

EVENTS OF DEFAULT 

Section 6.01. Events of Default. The following Sections 6.01(5) and 6.01(6) shall replace Sections 6.01(5) and 6.01(6),
respectively, in the Indenture: 
 (5) any default or event of default under any Indebtedness of the Company or any of its
Subsidiaries (other than any Indebtedness of the Company or any Subsidiary to the seller of a business or asset incurred in connection with the purchase thereof) which default or event of default results in at least $100.0 million of aggregate
principal amount of such Indebtedness being declared due and payable prior to maturity (the “cross acceleration provision”); 

(6) failure by the Company or any of its Subsidiaries to pay at maturity or otherwise when due (after giving effect to any applicable grace
period) at least $100.0 million aggregate principal amount of Indebtedness at any one time; 
 ARTICLE 7 

MISCELLANEOUS 

Section 7.01. Successors and Assigns. All of the covenants, stipulations, promises and agreements in this Supplemental
Indenture contained by or on the behalf of the Company shall bind its successors and assigns, whether so expressed or not. 

Section 7.02. Effectiveness. This Supplemental Indenture shall become effective upon its execution and delivery.

 Section 7.03. Ratification of Indenture. The Indenture as supplemented by this Supplemental Indenture, is in all
respects ratified and confirmed, and this Supplemental Indenture shall be deemed part of the Indenture in the manner and to the extent herein and therein provided. 

Section 7.04. Governing Law. This Supplemental Indenture shall be deemed to be a contract made under the internal laws of
the State of New York, and for all purposes shall be construed in accordance with the laws of said State, but without giving effect to applicable principles of conflicts of law to the extent that the application of the laws of another jurisdiction
would be required thereby. 
 Section 7.05. Multiple Originals. The parties may sign any number of copies of this
Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. One signed copy is enough to prove this Supplemental Indenture. 

Section 7.06. Headings. The headings of the Sections of this Supplemental Indenture have been inserted for convenience of
reference only, are not intended to be considered a part hereof and shall not modify or restrict any of the terms or provisions hereof. 

  
 12 

 IN WITNESS WHEREOF, the parties have caused this Supplemental Indenture to be duly executed as of
the date first written above. 
  

			
	LABORATORY CORPORATION OF AMERICA HOLDINGS
		
	By:	 	 /s/ F. Samuel Eberts III

		 	Name: F. Samuel Eberts III
		 	Title: Senior Vice President, Chief Legal Officer and Secretary

  

			
	U.S. BANK NATIONAL ASSOCIATION, Trustee
		
	By:	 	 /s/ Allison Lancaster-Poole

		 	Name: Allison Lancaster-Poole
		 	Title: Vice President

 [Signature Page to Eleventh Supplemental Indenture] 

 Exhibit A 

[FORM OF INITIAL NOTE] 
 EXCEPT AS OTHERWISE
PROVIDED IN SECTION 2.11 OF THE INDENTURE, THIS NOTE MAY BE TRANSFERRED, IN WHOLE BUT NOT IN PART, ONLY TO THE DEPOSITARY, ANOTHER NOMINEE OF THE DEPOSITARY OR TO A SUCCESSOR DEPOSITARY OR TO A NOMINEE OF SUCH SUCCESSOR DEPOSITARY 

CUSIP No. 50540R AT9 

ISIN No. US50540RAT95 
 No.
[1][2] 
 $[500,000,000][100,000,000] 

3.250% Senior Note due 2024 

Laboratory Corporation of America Holdings, a Delaware corporation, promises to pay to CEDE & CO., or registered assigns, the
principal amount set forth on Schedule I hereto on September 1, 2024. 
 Interest Payment Dates: March 1 and September 1,
commencing March 1, 2018. 
 Record Dates: February 15 and August 15. 

Additional provisions of this Note are set forth on the other side of this Note. 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

Dated: 
  

			
	LABORATORY CORPORATION OF AMERICA HOLDINGS
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

 

			
	U.S. Bank National Association, as Trustee, certifies that this is one of the Securities referred to in the Indenture.
		
	By:	 	  

		 	Authorized Signatory

 Dated: 

 [FORM OF REVERSE OF NOTE] 

3.250% Senior Note due 2024 
  

	1.	Indenture 

 This Note is one of a duly authorized series of debt securities of Laboratory
Corporation of America Holdings, a Delaware corporation (such corporation, and its successors and assigns under the Indenture hereinafter referred to, being herein called the “Company”), designated as the 3.250% Senior Notes due 2024 (the
“Notes”) issued under an Indenture dated as of November 19, 2010 (the “Base Indenture”), as supplemented by the Eleventh Supplemental Indenture dated August 22, 2017 (the “Supplemental Indenture,” and
collectively with the Base Indenture, the “Indenture”), between the Company and the Trustee. The terms of the Notes include those stated in the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939
as in effect on the date of the Indenture (the “Act”). Terms defined in the Indenture and not defined herein have the meanings ascribed thereto in the Indenture. The Notes are subject to all such terms, and Holders are referred to the
Indenture and the Act for a statement of those terms. 
 The Notes are general unsecured obligations of the Company. The Company shall be
entitled, without notice to or consent of the Holders, to issue additional debt securities under the Indenture on the same terms and conditions as the Notes (except for the interest accrual date and first Interest Payment Date) in accordance with
the Indenture. The Notes and any additional debt securities will be treated as a single series of debt securities for all purposes under the Indenture. The Indenture contains covenants that limit the ability of the Company and its Restricted
Subsidiaries to create Liens on assets and engage in Sale and Leaseback Transactions. The Indenture also contains a covenant that limits the ability of the Company’s Subsidiaries from incurring Indebtedness or issuing Preferred Stock. These
covenants are subject to important exceptions and qualifications. 
  

	2.	Interest 

 The Company promises to pay interest on the principal amount of this Note at the rate
per annum shown above. The Company shall pay interest semi-annually on March 1 and September 1 of each year, commencing March 1, 2018. Interest on the Notes shall accrue from the most recent date to which interest has been paid or, if
no interest has been paid, from August 22, 2017. Interest shall be computed on the basis of a 360-day year of twelve 30-day months. The Company shall pay interest on overdue principal at the rate borne by the Notes plus 1% per annum, and
it shall pay interest on overdue installments of interest at the same rate to the extent lawful. 
  

	3.	Method of Payment 

 The Company shall pay interest on the Notes (except Defaulted Interest) to
the Persons who are registered holders of Notes at the close of business on the February 15 or 

  
 4 

 
August 15 next preceding the Interest Payment Date even if the Notes are canceled after the record date and on or before the Interest Payment Date. Holders must surrender Notes to a Paying
Agent to collect principal payments. The Company shall pay principal and interest in money of the United States that at the time of payment is legal tender for payment of public and private debts. Payments in respect of the Notes represented by a
Global Security (including principal, premium and interest) will be made by wire transfer of immediately available funds to the accounts specified by The Depository Trust Company. The Company shall make all payments in respect of a certificated Note
(including principal, premium and interest) by mailing a check to the registered address of each Holder thereof; provided that payments on a certificated Note will be made by wire transfer to a U.S. dollar account maintained by the payee with a bank
in the United States if such Holder elects payment by wire transfer by giving written notice to the Trustee or the Paying Agent to such effect designating such account no later than 30 days immediately preceding the relevant due date for payment (or
such other date as the Trustee may accept in its discretion). 
  

	4.	Paying Agent and Security Registrar 

 Initially, U.S. Bank National Association, a national
banking association (the “Trustee”), will act as Paying Agent and Security Registrar. The Company may appoint and change any Paying Agent, Security Registrar or co-Security Registrar without notice. The Company or any of its domestically
incorporated wholly owned Subsidiaries may act as Paying Agent, Security Registrar or co-Security Registrar. 
  

	5.	Optional Redemption 

 In accordance with Section 3.01 of the Indenture, the Notes are
subject to redemption, in whole or in part, at any time, or from time to time, prior to July 1, 2024, at the option of the Company, at a redemption price equal to the greater of (1) 100% of the principal amount of the Notes being redeemed
plus accrued and unpaid interest to the redemption date or (2) the Make-Whole Amount for the Notes, which shall include a make-whole spread of 0.20%. 

On or after July 1, 2024, the Notes are subject to redemption, in whole or in part, at any time, or from time to time, at the option of
the Company, at a redemption price equal to 100% of the principal amount of the Notes being redeemed, plus accrued and unpaid interest to the redemption date. 

Notice of redemption will be mailed at least 30 days but not more than 60 days before the redemption date to each Holder of Notes to be
redeemed at his registered address. Notes in denominations larger than $1,000 principal amount may be redeemed in part but only in whole multiples of $1,000. If money sufficient to pay the redemption price of, which shall include accrued interest
on, all Notes (or portions thereof) to be redeemed on the redemption date is deposited with the Paying Agent on or before the redemption date and certain other conditions are satisfied, on and after such date interest ceases to accrue on such Notes
(or such portions thereof) called for redemption. 

  
 5 

	6.	Offer to Repurchase 

 If a Change of Control Repurchase Event occurs, unless the Company has
exercised its right to redeem the Notes as described in paragraph 5 of the Note, the Company shall make an offer to each Holder of Notes to repurchase all or any part (in multiples of $1,000 principal amount) of that Holder’s Notes at a
repurchase price in cash equal to 101% of the aggregate principal amount of Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to the date of purchase. Within 30 days following any Change of Control Repurchase Event or,
at the option of the Company, prior to any Change of Control, but after the public announcement of the Change of Control, the Company will mail a notice to each Holder describing the transaction or transactions that constitute or may constitute the
Change of Control Repurchase Event and offer to repurchase Notes on the payment date specified in the notice, which date shall be no earlier than 30 days and no later than 60 days from the date such notice is mailed. The notice shall, if mailed
prior to the date of consummation of the Change of Control, state that the offer to purchase is conditioned on the Change of Control Repurchase Event occurring on or prior to the payment date specified in the notice. The Company shall comply with
the requirements of Rule 14e-1 under the Securities Exchange Act of 1934 (the “Exchange Act”) and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the
repurchase of the Notes as a result of a Change of Control Repurchase Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control Repurchase Event provisions of this paragraph 6, the Company
will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the provisions of this paragraph 6 and all other provisions of the Indenture applicable to the Change of Control Repurchase
Event provisions of the Notes by virtue of such conflict. 
 On the Change of Control Repurchase Event payment date, the Company shall, to
the extent lawful: 
  

	 	i.	accept for payment all Notes or portions of Notes properly tendered pursuant to its offer; 

  

	 	ii.	deposit with the Paying Agent an amount equal to the aggregate purchase price in respect of all Notes or portions of Notes properly tendered; and 

 

	 	iii.	deliver or cause to be delivered to the Trustee the Notes properly accepted, together with an Officers’ Certificate stating the aggregate principal amount of Notes being purchased by the Company. 

The Paying Agent will promptly mail to each Holder of Notes properly tendered the purchase price for the Notes, and the Trustee will promptly
authenticate and mail (or cause to be transferred by book-entry) to each Holder a new note equal in principal amount to any unpurchased portion of any Notes surrendered; provided that each new note will be in a principal amount of $1,000 or an
integral multiple of $1,000 in excess thereof. 

  
 6 

 The Company shall not be required to make an offer to repurchase the Notes upon a Change of
Control Repurchase Event if a third party makes an offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and such third party purchases all Notes properly tendered and not withdrawn
under its offer. 
  

	 	(a)	For purposes of the foregoing: 

 “Below Investment Grade Rating Event” means the Notes
are rated below Investment Grade by both Rating Agencies on any date from the date of the public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the occurrence of a
Change of Control, which period shall be extended so long as the rating of the Notes is under publicly announced consideration for possible downgrade by either of the Rating Agencies. 

“Change of Control” means the occurrence of any of the following: 

 

	 	(a)	the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the properties or
assets of the Company and those of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other than the Company or a Subsidiary Guarantor that is a wholly owned Subsidiary
of the Company; 

  

	 	(b)	the adoption of a plan relating to the liquidation or dissolution of the Company; 

  

	 	(c)	the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act),
other than the Company or a Subsidiary Guarantor that is a wholly-owned Subsidiary of the Company, becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the
Voting Stock of the Company, measured by voting power rather than number of shares; or 

  

	 	(d)	the first day on which a majority of the members of the Board of Directors are not Continuing Directors. 

Notwithstanding the foregoing, a transaction effected to create a holding company for the Company will not be deemed to involve a Change of
Control if (1) pursuant to such transaction the Company becomes a wholly owned Subsidiary of such holding company and (2) the holders of the Voting Stock of such holding company immediately following such transaction are the same as the
holders of the Voting Stock of the Company immediately prior to such transaction. 

  
 7 

 “Change of Control Repurchase Event” means the occurrence of a Change of Control and a
Below Investment Grade Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member of the Board of
Directors who: 
  

	 	(a)	was a member of such Board of Directors on the first date that any of the Notes were issued; or 

  

	 	(b)	was nominated for election or elected to the Board of Directors with the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election.

 “Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) (or, in each case, if such Rating Agency ceases to rate the Notes for reasons outside of the Control of the Company, the
equivalent investment grade credit rating from any Rating Agency selected by the Company as a replacement Rating Agency). 

“Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s Corporation, and its successors. 

“Rating Agency” means: 
  

	 	(a)	each of Moody’s and S&P; and 

  

	 	(b)	if either of Moody’s or S&P ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons outside of the Control of the Company, a “nationally recognized statistical rating
organization” within the meaning of Section 3(a)(62) of the Exchange Act selected by the Company as a replacement agency for Moody’s or S&P, or both, as the case may be. 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and its successors.

 “Voting Stock”, as applied to stock of any Person, means shares, interests, participations or other equivalents in the equity
interest (however designated) in such Person having ordinary voting power for the election of a majority of the directors (or the equivalent) of such Person, other than shares, interests, participations or other equivalents having such power only by
reason of the occurrence of a contingency. 
  

	7.	Denominations; Transfer; Exchange 

 The Notes are in registered form without coupons in
denominations of one thousand U.S. dollars ($1,000) principal amount or any integral multiple thereof. A Holder may transfer or exchange Notes in accordance with the Indenture. The Security 

  
 8 

 
Registrar may require a Holder, among other things, to furnish appropriate endorsements or transfer documents and to pay any taxes or governmental charge in relation thereto or permitted by the
Indenture. The Company shall not be required (i) to issue, exchange or register the transfer of any Notes during a period beginning at the opening of business 15 days before the day of the mailing of a notice of redemption of less than all the
outstanding Notes of the same series and ending at the close of business on the day of such mailing, nor (ii) to register the transfer of or exchange any Notes of any series or portions thereof called for redemption. 

 

	8.	Persons Deemed Owners 

 The registered Holder of this Note may be treated as the owner of it for
all purposes. 
  

	9.	Unclaimed Money 

 Subject to any applicable abandoned property law, the Trustee and the Paying
Agent shall pay to the Company upon request any money held by them for the payment of principal or interest on the Notes that remains unclaimed for two years, and, thereafter, Securityholders entitled to the money must look to the Company for
payment as general creditors. 
  

	10.	Discharge and Defeasance 

 Subject to certain conditions, the Company at any time may terminate
some or all of its obligations under the Notes and the Indenture if the Company irrevocably deposits in trust with the Trustee money or Government Obligations for the payment of principal and interest on the Notes to redemption or maturity, as the
case may be and other conditions to defeasance are met. 
  

	11.	Amendment, Waiver 

 Subject to certain exceptions set forth in the Indenture, (i) the
Indenture with respect to the Notes and the Notes may be amended with the written consent of the Holders of not less than a majority in principal amount of the Notes outstanding and (ii) any default or noncompliance with any provision of the
Indenture with respect to the Notes may be waived with the written consent of the Holders of a majority in principal amount outstanding of the Notes. 

Subject to certain exceptions set forth in the Indenture, without the consent of any Securityholder, the Company and the Trustee shall be
entitled to amend the Indenture or the Notes to cure any ambiguity, defect or inconsistency, or to comply with Article V of the Base Indenture, or to provide for uncertificated Notes in addition to or in place of certificated Notes, or to add
additional covenants or to surrender rights and powers conferred on the Company or to add additional events of defaults or to add guarantees or to make any change that does not adversely affect the rights of any Securityholder in any material
respect or to provide for the issuance of a new series of debt securities under the Indenture or to evidence the appointment of a successor Trustee. 

  
 9 

	12.	Defaults and Remedies 

 Under the Indenture, Events of Default for the Notes include
(i) default for 30 days in payment of interest on the Notes; (ii) default in payment of principal on the Notes, upon redemption pursuant to paragraph 5 of the Notes, upon acceleration or otherwise; (iii) failure by the Company to
comply with other agreements in the Indenture or the Notes, in certain cases subject to notice and lapse of time; (iv) certain accelerations of other Indebtedness of the Company or any of its Subsidiaries if the amount accelerated (or so
unpaid) is at least $100.0 million; (v) failure by the Company or any Subsidiary to pay at maturity at least $100.0 million of other Indebtedness; and (vi) certain events of bankruptcy or insolvency with respect to the Company. 

Securityholders may not enforce the Indenture or the Notes except as provided in the Indenture. The Trustee may refuse to enforce the
Indenture or the Notes unless it receives indemnity or security satisfactory to it. Subject to certain limitations, Holders of a majority in principal amount of the Notes may direct the Trustee in its exercise of any trust or power with respect to
the Notes. The Trustee may withhold from Securityholders notice of any continuing Default (except a Default in payment of principal or interest) if it determines that withholding notice is in the interest of the Holders. 

 

	13.	Trustee Dealings with the Company 

 Subject to certain limitations imposed by the Act, the
Trustee in its individual or any other capacity may become the owner or pledgee of Notes and may otherwise deal with the Company or its Affiliates with the same rights it would have if it were not Trustee. 

 

	14.	No Recourse Against Others 

 An incorporator, stockholder, officer or director, as such, of the
Company or the Trustee shall not have any liability for any obligations of the Company under the Notes or the Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. By accepting a Note, each
Securityholder waives and releases all such liability. The waiver and release are part of the consideration for the issue of the Notes. 
  

	15.	Authentication 

 This Note shall not be valid until an authorized signatory of the Trustee (or
an Authenticating Agent) manually signs the certificate of authentication on the other side of this Note. 
  

	16.	Abbreviations 

 Customary abbreviations may be used in the name of a Securityholder or an
assignee, such as TEN COM (=tenants in common), TEN ENT (=tenants by the entireties), JT TEN (=joint tenants with rights of survivorship and not as tenants in common), CUST (=custodian), and U/G/M/A (=Uniform Gifts to Minors Act). 

  
 10 

	17.	CUSIP Numbers 

 Pursuant to a recommendation promulgated by the Committee on Uniform Security
Identification Procedures, the Company has caused CUSIP numbers to be printed on the Notes and has directed the Trustee to use CUSIP numbers in notices of redemption as a convenience to Securityholders. No representation is made as to the accuracy
of such numbers either as printed on the Notes or as contained in any notice of redemption and reliance may be placed only on the other identification numbers placed thereon. 
  

	18.	Governing Law 

 THIS NOTE SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF
THE STATE OF NEW YORK BUT WITHOUT GIVING EFFECT TO APPLICABLE PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY. 

  
 11 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
 I or we assign
and transfer this Note to 
 (Print or type assignee’s name, address and zip code) 

(Insert assignee’s soc. sec. or tax I.D. No.) 

and irrevocably appoint                     agent to
transfer this Note on the books of the Company. The agent may substitute another to act for him. 
  

									
	 
	
	 
				
	Date:	 	  
	  	Your Signature:	  	  

	
	 
	
	 

 Sign exactly as your name appears on the face of this Note. 

  
 12 

 Option of Holder to Elect Purchase 

The undersigned elects to have this Note or the portion hereof (which is a multiple of $1,000 principal amount) designated below purchased by
the Company upon a Change of Control Repurchase Event pursuant to paragraph 6 on the reverse of this Note: 
  

					
	Date:	  	  
	  	
			
	Your Signature:	  	  
	  	

 (Sign exactly as your name appears on the
face of this Note) 

					
			
	 Tax Identification No.:
	  	  
	  	
			
	 Signature Guarantee*:
	  	  
	  	

  

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 

Principal amount to be purchased (if less than all): $        ,000 

  
 13 

 LABORATORY CORPORATION OF AMERICA HOLDINGS 

3.250% SENIOR NOTE DUE 2024 
  

 

					
	No.	  		  	Schedule I*
			
	 Date
	  	 Principal amount of this Global
Note
	  	 Notation

		  	$	  	Original issuance

  

	*	To be attached to Global Note only. 

  
 14EX-4.3

 Exhibit 4.3 

$600,000,000 
 3.600%
SENIOR NOTES DUE 2027 
 LABORATORY CORPORATION OF AMERICA HOLDINGS 

as 
 Issuer 

AND 
 U.S. BANK NATIONAL
ASSOCIATION 
 as 

Trustee 
 TWELFTH
SUPPLEMENTAL INDENTURE 
 DATED AS OF AUGUST 22, 2017 

 TABLE OF CONTENTS 

 
  

					
	 	  	PAGE	 
	ARTICLE 1	  			
	RELATION TO INDENTURE; DEFINITIONS; RULES OF CONSTRUCTION	  			
		
	 Section 1.01. Scope of Supplemental Indenture
	  	 	1	 
	 Section 1.02. Relation To Indenture
	  	 	1	 
	 Section 1.03. Definitions
	  	 	2	 
	 Section 1.04. Capitalized Terms
	  	 	6	 
		
	ARTICLE 2	  			
	THE SECURITIES	  			
		
	 Section 2.01. Title of the Securities
	  	 	6	 
	 Section 2.02. Aggregate Principal Amount
	  	 	6	 
	 Section 2.03. Maturity Date
	  	 	6	 
	 Section 2.04. Ranking
	  	 	6	 
	 Section 2.05. Interest
	  	 	6	 
	 Section 2.06. Issuance Price
	  	 	6	 
	 Section 2.07. Defeasance
	  	 	7	 
	 Section 2.08. Form and Dating
	  	 	7	 
	 Section 2.09. Conversion
	  	 	7	 
	 Section 2.10. Guarantees
	  	 	7	 
		
	ARTICLE 3	  			
	OPTIONAL REDEMPTION	  			
		
	 Section 3.01. Optional Redemption
	  	 	7	 
		
	ARTICLE 4	  			
	ADDITIONAL COVENANTS	  			
		
	 Section 4.01. Limitation on Liens
	  	 	8	 
	 Section 4.02. Limitation on Sale and Leaseback Transactions
	  	 	9	 
	 Section 4.03. Limitation on Subsidiary Indebtedness and Preferred Stock
	  	 	10	 
		
	ARTICLE 5	  			
	OFFER TO REPURCHASE	  			
		
	 Section 5.01. Offer to Repurchase
	  	 	10	 
		
	ARTICLE 6	  			
	EVENTS OF DEFAULT	  			
		
	 Section 6.01. Events of Default
	  	 	12	 

  
 i 

					
	 	  	PAGE	 
		
	ARTICLE 7	  			
	MISCELLANEOUS	  			
		
	 Section 7.01. Successors and Assigns
	  	 	12	 
	 Section 7.02. Effectiveness
	  	 	12	 
	 Section 7.03. Ratification of Indenture
	  	 	12	 
	 Section 7.04. Governing Law
	  	 	12	 
	 Section 7.05. Multiple Originals
	  	 	12	 
	 Section 7.06. Headings
	  	 	12	 

  

  
 ii 

 TWELFTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of
August 22, 2017 between Laboratory Corporation of America Holdings, a Delaware corporation (or its permitted successor) (the “Company”), and U.S. Bank National Association, as Trustee under the Indenture (the “Trustee”).

 W I T N E S S E T H 

WHEREAS, the Company has heretofore executed and delivered to the Trustee an indenture (the “Indenture”), dated as of
November 19, 2010; 
 WHEREAS, the Company proposes to create under the Indenture a new series of Securities in the form of senior
notes to be designated as the 3.600% Senior Notes due 2027; 
 WHEREAS, Section 2.01 of the Indenture provides that at or prior to the
issuance of any Securities within a series, the terms of the series of Securities shall be established by a supplemental indenture or an Officers’ Certificate pursuant to authority granted under resolutions of the Board of Directors of the
Company; 
 WHEREAS, the Company desires to provide for the establishment of a series of Securities under the Indenture, and the form of and
terms thereof as hereinafter set forth; and 
 WHEREAS, the Company has requested that the Trustee execute and deliver this Supplemental
Indenture and all conditions necessary to authorize the execution and delivery of this Supplemental Indenture and to make it a valid and binding agreement of the Company have been done or performed. 

NOW THEREFORE, in consideration of the foregoing and for good and valuable consideration, the receipt of which is hereby acknowledged, the
Company, and the Trustee mutually covenant and agree for the equal and ratable benefit of the Holders of the Securities as follows: 

ARTICLE 1 
 RELATION
TO INDENTURE; DEFINITIONS; RULES OF CONSTRUCTION 

Section 1.01. Scope of Supplemental Indenture. The changes, modifications and supplements to the Indenture effected by this
Supplemental Indenture shall be applicable only with respect to, and shall only govern the terms of, the Notes (as defined below) and shall not apply to any other Securities that may be issued under the Indenture unless a supplemental indenture with
respect to such other Securities specifically incorporates such changes, modifications and supplements. The provisions of this Supplemental Indenture shall supersede any corresponding provisions in the Indenture. 

Section 1.02. Relation To Indenture. This Supplemental Indenture constitutes an integral part of the Indenture. 

  
 1 

 Section 1.03. Definitions. For all purposes of this Supplemental Indenture, the
following terms shall have the respective meanings set forth in this Section. 
 “Acquired Indebtedness” means Indebtedness of a
Person (i) existing at the time such Person becomes a Subsidiary of the Company or (ii) assumed in connection with the acquisition of assets by such Person, in each case, other than Indebtedness incurred in connection with, or in
contemplation of, such Person becoming a Subsidiary of the Company or such acquisition, as the case may be. For purposes of Section 4.03 hereof, any Acquired Indebtedness shall not be deemed to have been incurred until 270 days from the date
(A) the Person obligated on such Acquired Indebtedness becomes a Subsidiary of the Company or (B) the acquisition of assets, in connection with which such Acquired Indebtedness was assumed, is consummated. 

“Adjusted Treasury Rate” means, with respect to any redemption date, (i) the yield, under the heading which represents the
average for the immediately preceding week, appearing in, or available through, the most recently published statistical release designated “H.15” or any successor publication which is published weekly by the Board of Governors of the
Federal Reserve System (or companion online data resource published by the Board of Governors of the Federal Reserve System) and which establishes yields on actively traded United States Treasury securities adjusted to constant maturity under the
caption “Treasury Constant Maturities,” for the maturity corresponding to the Comparable Treasury Issue (if no maturity is within three months before or after the remaining term of the Notes being redeemed (assuming that the Notes matured
on the Par Call Date), yields for the two published maturities most closely corresponding to the Comparable Treasury Issue shall be determined and the Adjusted Treasury Rate shall be interpolated or extrapolated from such yields on a straight line
basis, rounding to the nearest month) or (ii) if such release (or any successor release) is not published during the week preceding the calculation date or does not contain such yields, the rate per year equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue (expressed as a percentage of its principal amount) assuming a price for the Comparable Treasury Issue equal to the Comparable Treasury Price for such redemption date, in each case calculated on the
third business day preceding the redemption date, plus the make-whole spread specified in Section 3.01 of this Supplemental Indenture. 

“Attributable Debt” means, with respect to a Sale and Leaseback Transaction, an amount equal to the lesser of: (1) the fair
market value of the property (as determined in good faith by the Company’s Board of Directors); and (2) the present value of the total net amount of rent payments to be made under the lease during its remaining term, discounted at the rate
of interest set forth or implicit in the terms of the lease, compounded semi-annually. 
 “Below Investment Grade Rating Event”
means the Notes are rated below Investment Grade by both Rating Agencies on any date from the date of the public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the
occurrence of a Change of Control, which period shall be extended so long as the rating of the Notes is under publicly announced consideration for possible downgrade by either of the Rating Agencies. 

  
 2 

 “Capitalized Lease” means any obligation of a Person to pay rent or other amounts
incurred with respect to real property or equipment acquired or leased by such Person and used in its business that is required to be recorded as a capital lease in accordance with GAAP; provided that, for purposes of this definition only,
“GAAP” shall mean GAAP as in effect as of the date of this Supplemental Indenture and not as in effect from time to time. 

“Change of Control” means the occurrence of any of the following: 

 

	 	(a)	the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the properties or
assets of the Company and those of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other than the Company or a Subsidiary Guarantor that is a wholly owned Subsidiary
of the Company; 

  

	 	(b)	the adoption of a plan relating to the liquidation or dissolution of the Company; 

  

	 	(c)	the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act),
other than the Company or a Subsidiary Guarantor that is a wholly-owned Subsidiary of the Company, becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the
Voting Stock of the Company, measured by voting power rather than number of shares; or 

  

	 	(d)	the first day on which a majority of the members of the Board of Directors are not Continuing Directors. 

Notwithstanding the foregoing, a transaction effected to create a holding company for the Company will not be deemed to involve a Change of
Control if (1) pursuant to such transaction the Company becomes a wholly owned Subsidiary of such holding company and (2) the holders of the Voting Stock of such holding company immediately following such transaction are the same as the
holders of the Voting Stock of the Company immediately prior to such transaction. 
 “Change of Control Repurchase Event” means
the occurrence of a Change of Control and a Below Investment Grade Rating Event. 
 “Comparable Treasury Issue” means the United
States Treasury security selected by the quotation agent as having a maturity comparable to the remaining term from the redemption date to the Par Call Date of the Notes being redeemed that would be utilized,

  
 3 

 
at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of the Securities.

 “Comparable Treasury Price” means, with respect to any redemption date, if clause (ii) of the Adjusted Treasury Rate is
applicable, the average of three, or such lesser number as is obtained by the trustee, Reference Treasury Dealer quotations for such redemption date. 

“Consolidated Total Assets” means, with respect to any Person as of any date, the amount of total assets as shown on the
consolidated balance sheet of such Person for the most recent fiscal quarter for which financial statements have been filed with the Commission, prepared in accordance with GAAP. 

“Continuing Directors” means, as of any date of determination, any member of the Board of Directors who: 

 

	 	(a)	was a member of such Board of Directors on the first date that any of the Notes were issued; or 

  

	 	(b)	was nominated for election or elected to the Board of Directors with the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election.

 “Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) (or, in each case, if such Rating Agency ceases to rate the Notes for reasons outside of the Control of the Company, the
equivalent investment grade credit rating from any Rating Agency selected by the Company as a replacement Rating Agency). 

“Make-Whole Amount” means the sum, as determined by a quotation agent, of the present values of the scheduled payments of principal
and interest (exclusive of interest to the redemption date) from the redemption date to the Par Call Date, in each case discounted to the redemption date on a semi-annual basis, assuming a 360-day year consisting of twelve 30-day months, at the
Adjusted Treasury Rate. 
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s Corporation,
and its successors. 
 “Notes” means the $600,000,000 3.600% Senior Notes due 2027 whose CUSIP is 50540R AU6. 

“Par Call Date” means June 1, 2027. 

“Permitted Acquired Indebtedness” means any Acquired Indebtedness that remains outstanding following the expiration of a good faith
offer by the Company or a 

  
 4 

 
Subsidiary of the Company obligated under such Acquired Indebtedness to acquire such Acquired Indebtedness, including, without limitation, an offer to exchange such Acquired Indebtedness for debt
securities for the Company, on terms, which in the opinion of an independent investment banking firm of national reputation and standing, are consistent with market practices in existence at the time for offers of a similar nature; provided that the
initial expiration date of any such offer shall be not later than the expiration of the 270-day period referred to in the definition of “Acquired Indebtedness”; provided further, that the amount of Acquired Indebtedness that shall
constitute “Permitted Acquired Indebtedness” shall only be equal to the amount of Acquired Indebtedness that the Company or such Subsidiary of the Company has made an offer to acquire in accordance with the foregoing. 

“Principal Property” means any real property and any related buildings, fixtures or other improvements located in the United States
owned by the Company or its Subsidiaries (1) that is an operating property included in the list of principal properties in Item 2 (or any successor Item thereto) of the annual report on Form 10-K of the Company filed with the Commission
for the most recently ended fiscal year, or is an operating property acquired subsequent to such filing that would have been included in such Item 2 if it had been owned prior to the date of such filing or (2) the net book value of which
as of the end of the last fiscal quarter ending immediately prior to the date of determination exceeds 1% of the Consolidated Total Assets of the Company as of the same date. 

“Rating Agency” means: 

(a) each of Moody’s and S&P; and 

(b) if either of Moody’s or S&P ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons
outside of the Control of the Company, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act selected by the Company as a replacement agency for Moody’s or S&P,
or both, as the case may be. 
 “Reference Treasury Dealer” means Citigroup Global Markets Inc. and its successors and assigns,
Merrill Lynch, Pierce, Fenner & Smith Incorporated and its successors and assigns and a primary U.S. government securities dealer selected by Wells Fargo Securities, LLC. 

“Restricted Subsidiary” means any Subsidiary of the Company that owns a Principal Property. 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and its successors.

 “Sale and Leaseback Transaction” means any arrangement with any Person providing for the leasing by the Company or any
Restricted Subsidiary of real or personal property that is to be sold or transferred by the Company or such Restricted Subsidiary to such Person or to any other Person to whom funds have been or are to be advanced by such Person on the security of
such property or rental obligations of the Company or such Restricted Subsidiary. 

  
 5 

 “Voting Stock”, as applied to stock of any Person, means shares, interests,
participations or other equivalents in the equity interest (however designated) in such Person having ordinary voting power for the election of a majority of the directors (or the equivalent) of such Person, other than shares, interests,
participations or other equivalents having such power only by reason of the occurrence of a contingency. 
 Section 1.04.
Capitalized Terms. Capitalized terms used herein but not defined shall have the meanings assigned to them in the Indenture. 
 ARTICLE
2 
 THE SECURITIES 

There is hereby established a series of Securities pursuant to the Indenture with the following terms: 

Section 2.01. Title of the Securities. The series of Securities shall be designated the 3.600% Senior Notes due 2027 (the
“Notes”) whose CUSIP is 50540R AU6. 
 Section 2.02. Aggregate Principal Amount. The Notes shall be initially issued
in an aggregate principal amount of $600,000,000 (not including the Notes authenticated and delivered upon registration of, transfer of, or in exchange for, or in lieu of, other Notes pursuant to Sections 2.05, 2.06, 2.07, 2.08, 3.01 or 10.02 of the
Indenture) and additional Notes may be issued from time to time without notice to or consent of the Holders, provided that if the additional Notes are not fungible with the then-outstanding Notes for U.S. federal income tax purposes, the additional
Notes shall have a separate CUSIP number. 
 Section 2.03. Maturity Date. The date on which the principal, and all accrued and
unpaid interest on, the Notes is payable is September 1, 2027, subject to the provisions of the Indenture relating to acceleration. 

Section 2.04. Ranking. The Notes shall be unsecured senior debt of the Company and shall rank on a parity with all other unsecured
and unsubordinated Indebtedness of the Company. 
 Section 2.05. Interest. The Notes shall bear interest from August 22,
2017, or from the most recent Interest Payment Date to which interest has been paid or duly provided for, at a rate of 3.600% per annum, payable semi-annually on March 1 and September 1 of each year, commencing March 1, 2018. The
Company shall pay interest to the Person in whose name a Note is registered at the close of business on the February 15 or August 15, as the case may be, preceding the Interest Payment Date. The Company shall compute interest on the basis
of a 360-day year consisting of twelve 30-day months. 
 Section 2.06. Issuance Price. [Intentionally Omitted] 

  
 6 

 Section 2.07. Defeasance. The Notes shall be subject to defeasance under
Section 10.02 of the Indenture, provided that for purposes of Sections 10.03(6) and (7) of the Indenture, the term “Securityholders” shall refer to the beneficial owners of the Notes. 

Section 2.08. Form and Dating. (a) The Notes shall be substantially in the form of Exhibit A hereto. The Notes may have
notations, legends or endorsements required by law, stock exchange rule or usage. Each Note shall be dated the date of its authentication. 

(b) The terms and provisions contained in the Notes shall constitute, and are hereby expressly made, a part of this Supplemental Indenture,
and the Company and the Trustee, by their execution and delivery of this Supplemental Indenture, expressly agree to such terms and provisions and to be bound thereby. However, to the extent any provision of any Notes conflicts with the express
provisions of this Supplemental Indenture, the provisions of this Supplemental Indenture shall govern and be controlling. 
 (c) The Notes
shall be issued in the form of fully-registered Global Securities. The Global Securities shall be deposited with, or on behalf of, the Depositary and registered in the name of the Depositary or its nominee. Except as set forth in Section 2.11
of the Indenture, the Global Securities may be transferred, in whole and not in part, only by the Depositary to its nominee or by its nominee to such Depositary or another nominee of the Depositary or by the Depositary or its nominee to a successor
of the Depositary or a nominee of such successor. In addition, the Company may at any time determine not to have the Notes represented by Global Securities, and, in such event, will issue Notes in certificated form in exchange for the Global
Securities. In either instance, an owner of an interest in the Global Securities would be entitled to physical delivery of such Notes in certificated form. Notes so issued in certificated form shall be issued in denominations of $1,000 and integral
multiples of $1,000 in excess thereof and shall be issued in registered form only. 
 Section 2.09. Conversion. The Notes shall
not be convertible into any shares of common stock of the Company or other securities of the Company. 
 Section 2.10.
Guarantees. The Notes are not guaranteed by any guarantor. 
 ARTICLE 3 

OPTIONAL REDEMPTION 

Section 3.01. Optional Redemption. Prior to June 1, 2027, the Company may redeem the Notes, in whole or in part, at any time,
or from time to time, at its option at a price equal to the greater of (1) 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest to the redemption date and (2) the Make-Whole Amount for the Notes, which
shall include a make-whole spread of 0.25%. 
 On or after June 1, 2027, the Company may redeem the Notes in whole or in part, at any
time, or from time to time, at its option, at a price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued and unpaid interest to the redemption date. 

  
 7 

 ARTICLE 4 

ADDITIONAL COVENANTS 

Section 4.01. Limitation on Liens. So long as any Notes are outstanding, the Company shall not, and shall not permit any
Restricted Subsidiary to, create, incur, assume or suffer to exist any Lien upon any Principal Property or shares of stock or Indebtedness of any Restricted Subsidiary to secure any Indebtedness, without effectively providing that the Notes shall
(so long as such other Indebtedness shall be so secured) be equally and ratably secured. 
 The foregoing limitation shall not apply to:

 (a) Liens for taxes not yet due or that are being contested in good faith by appropriate proceedings, provided that adequate reserves
with respect thereto are maintained on the books of the Company or the books of the Restricted Subsidiaries, as the case may be, in conformity with GAAP; 

(b) carriers’, warehousemen’s, mechanics’, materialmen’s, repairmen’s or other like Liens arising in the ordinary
course of business securing obligations that are not overdue for a period of more than 90 days or that are being contested in good faith by appropriate proceedings; 

(c) pledges or deposits in connection with workers’ compensation, unemployment insurance and other social security legislation and
deposits securing liability to insurance carriers under insurance or self-insurance arrangements; 
 (d) deposits to secure the performance
of bids, trade contracts (other than for borrowed money), leases, statutory obligations, surety and appeal bonds, performance bonds and other obligations of a like nature incurred in the ordinary course of business; 

(e) easements, rights-of-way, restrictions and other similar encumbrances incurred in the ordinary course of business that, in the aggregate,
are not substantial in amount and that do not in any case materially detract from the value of the property subject thereto or materially interfere with the ordinary conduct of the business of the Company or of such Restricted Subsidiary; 

(f) Liens in existence on the first date of the issuance of the Notes; 

(g) Liens arising in connection with trade letters of credit issued for the account of the Company or the account of a Restricted Subsidiary
securing the reimbursement obligations in respect of such letters of credit, provided, that such Liens encumber only the property being acquired through payments made under such letters of credit or the documents of title and shipping and insurance
documents relating to such property; 

  
 8 

 (h) Liens on intellectual property acquired by the Company or a Restricted Subsidiary (such as
software) securing the obligation of the Company or the obligation of such Restricted Subsidiary to make royalty or similar payments to the seller of such intellectual property, provided, that such Liens encumber only the intellectual property to
which such payments relate; 
 (i) any Lien upon any property or assets created at the time of the acquisition, purchase, lease, improvement
or development of property or assets used or held by the Company or any Restricted Subsidiary or within one year after such time to secure all or a portion of the purchase price or lease for, or the costs of improvement or development of, such
property or assets; 
 (j) any Lien upon any property or assets existing thereon at the time of the acquisition thereof (provided such Lien
was not incurred in anticipation of such acquisition) by the Company or any Restricted Subsidiary (whether or not the obligations secured thereby are assumed by the Company or any Restricted Subsidiary); 

(k) any Lien in favor of the Company or any Restricted Subsidiary; 

(l) Liens in respect of judgments that do not constitute an Event of Default; 

(m) Liens to secure any extension, renewal, refinancing or refunding (or successive extensions, renewals, refinancings or refundings), in
whole or in part, of any Indebtedness secured by Liens referred to in the foregoing clauses (f) through (l) or Liens created in connection with any amendment, consent or waiver relating to such Indebtedness, so long as such Lien does not extend to
any other property and the Indebtedness so secured does not exceed the fair market value (as determined by the Board of Directors) of the assets subject to such Liens at the time of such extension, renewal, refinancing or refunding, or such
amendment, consent or waiver, as the case may be; or 
 (n) any Lien securing any Indebtedness in an amount which, together with, without
duplication, (i) all other Indebtedness secured by a Lien that is not otherwise permitted by the foregoing provisions, (ii) the Attributable Debt of any Sale and Leaseback Transaction that is not otherwise permitted under clauses (a)
through (d) in Section 4.02, and (iii) any Indebtedness incurred by a Subsidiary of the Company pursuant to clause (c) in Section 4.03 does not at the time of the incurrence of the Indebtedness so secured exceed 5% of the Consolidated
Total Assets of the Company. 
 Section 4.02. Limitation on Sale and Leaseback Transactions. So long as any Notes are
outstanding, the Company shall not, and shall not permit any Restricted Subsidiary to, enter into any Sale and Leaseback Transaction with respect to any Principal Property unless: 

(a) the Sale and Leaseback Transaction involves a lease for a term of not more than five years; 

  
 9 

 (b) the Sale and Leaseback Transaction is between the Company and a Subsidiary Guarantor or
between Subsidiary Guarantors; 
 (c) the Company or a Restricted Subsidiary would be entitled to incur Indebtedness secured by a Lien on
such property or assets involved in such Sale and Leaseback Transaction without equally and ratably securing the Notes pursuant to Section 4.01; 

(d) the cash proceeds of such Sale and Leaseback Transaction are at least equal to the fair market value thereof or the debt attributable
thereto and the Company applies an amount equal to the greater of the net proceeds of such sale or the Attributable Debt with respect to such Sale and Leaseback Transaction within 270 days of such sale to either (or a combination) of (x) the
retirement (other than the mandatory retirement, mandatory prepayment or sinking fund payment or by payment at maturity) of the long-term debt of the Company or the long-term debt of a Restricted Subsidiary (other than long-term debt that is
subordinated to the Notes) or (y) the acquisition, purchase, improvement or development of other comparable property, including the acquisition of other businesses; or 

(e) the Attributable Debt of the Sale and Leaseback Transaction is in an amount which, together with, without duplication, (i) all of the
Attributable Debt of the Company and its Restricted Subsidiaries under this clause (e), (ii) all other Indebtedness secured by a Lien that is not otherwise permitted by the provisions of clauses (a) through (m) pursuant to Section 4.01, and
(iii) any Indebtedness incurred by a Subsidiary of the Company pursuant to clause (c) in Section 4.03 does not at the time of such transaction exceed 5% of the Consolidated Total Assets of the Company. 

Section 4.03. Limitation on Subsidiary Indebtedness and Preferred Stock. So long as any Notes are outstanding, the Company shall
not cause or permit its direct or indirect Subsidiaries to incur, create, issue, assume or permit to exist any Indebtedness or Preferred Stock (other than Permitted Indebtedness) unless the amount of such Indebtedness or Preferred Stock, when taken
together with, without duplication, (a) all other Indebtedness (other than Permitted Indebtedness) incurred pursuant to this Section 4.03, (b) all other Indebtedness secured by a Lien that is not otherwise permitted by the provisions
of clauses (a) through (m) in Section 4.01, and (c) the Attributable Debt of any Sale and Leaseback Transaction that is not otherwise permitted by the provisions of clauses (a) through (d) in Section 4.02, does not at the time of the incurrence
exceed the greater of (i) $750.0 million and (ii) 5% of the Consolidated Total Assets of the Company. 
 ARTICLE 5 

OFFER TO REPURCHASE 

Section 5.01. Offer to Repurchase. If a Change of Control Repurchase Event occurs, unless the Company has exercised its right to redeem
the Notes as described in Section 3.01, the Company shall make an offer to each Holder of Notes to repurchase all or any part (in multiples of $1,000 principal amount) of that Holder’s Notes at a

  
 10 

 
repurchase price in cash equal to 101% of the aggregate principal amount of Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to the date of purchase. Within 30 days
following any Change of Control Repurchase Event or, at the option of the Company, prior to any Change of Control, but after the public announcement of the Change of Control, the Company will mail a notice to each Holder describing the transaction
or transactions that constitute or may constitute the Change of Control Repurchase Event and offer to repurchase Notes on the payment date specified in the notice, which date shall be no earlier than 30 days and no later than 60 days from the date
such notice is mailed. The notice shall, if mailed prior to the date of consummation of the Change of Control, state that the offer to purchase is conditioned on the Change of Control Repurchase Event occurring on or prior to the payment date
specified in the notice. The Company shall comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the
repurchase of the Notes as a result of a Change of Control Repurchase Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control Repurchase Event provisions of the Notes, the Company will
comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control Repurchase Event provisions of the Notes by virtue of such conflict. 

On the Change of Control Repurchase Event payment date, the Company shall, to the extent lawful: 

(a) accept for payment all Notes or portions of Notes properly tendered pursuant to its offer; 

(b) deposit with the Paying Agent an amount equal to the aggregate purchase price in respect of all Notes or portions of Notes properly
tendered; and 
 (c) deliver or cause to be delivered to the Trustee the Notes properly accepted, together with an Officers’
Certificate stating the aggregate principal amount of Notes being purchased by the Company. 
 The Paying Agent will promptly mail to each
Holder of Notes properly tendered the purchase price for the Notes, and the Trustee will promptly authenticate and mail (or cause to be transferred by book-entry) to each Holder a new note equal in principal amount to any unpurchased portion of any
Notes surrendered; provided that each new note will be in a principal amount of $1,000 or an integral multiple of $1,000 in excess thereof. 

The Company shall not be required to make an offer to repurchase the Notes upon a Change of Control Repurchase Event if a third party makes an
offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and such third party purchases all Notes properly tendered and not withdrawn under its offer. 

  
 11 

 ARTICLE 6 

EVENTS OF DEFAULT 

Section 6.01. Events of Default. The following Sections 6.01(5) and 6.01(6) shall replace Sections 6.01(5) and 6.01(6),
respectively, in the Indenture: 
 (5) any default or event of default under any Indebtedness of the Company or any of its
Subsidiaries (other than any Indebtedness of the Company or any Subsidiary to the seller of a business or asset incurred in connection with the purchase thereof) which default or event of default results in at least $100.0 million of aggregate
principal amount of such Indebtedness being declared due and payable prior to maturity (the “cross acceleration provision”); 

(6) failure by the Company or any of its Subsidiaries to pay at maturity or otherwise when due (after giving effect to any applicable grace
period) at least $100.0 million aggregate principal amount of Indebtedness at any one time; 
 ARTICLE 7 

MISCELLANEOUS 

Section 7.01. Successors and Assigns. All of the covenants, stipulations, promises and agreements in this Supplemental
Indenture contained by or on the behalf of the Company shall bind its successors and assigns, whether so expressed or not. 

Section 7.02. Effectiveness. This Supplemental Indenture shall become effective upon its execution and delivery. 

Section 7.03. Ratification of Indenture. The Indenture as supplemented by this Supplemental Indenture, is in all respects
ratified and confirmed, and this Supplemental Indenture shall be deemed part of the Indenture in the manner and to the extent herein and therein provided. 

Section 7.04. Governing Law. This Supplemental Indenture shall be deemed to be a contract made under the internal laws of
the State of New York, and for all purposes shall be construed in accordance with the laws of said State, but without giving effect to applicable principles of conflicts of law to the extent that the application of the laws of another jurisdiction
would be required thereby. 
 Section 7.05. Multiple Originals. The parties may sign any number of copies of this
Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. One signed copy is enough to prove this Supplemental Indenture. 

Section 7.06. Headings. The headings of the Sections of this Supplemental Indenture have been inserted for convenience of
reference only, are not intended to be considered a part hereof and shall not modify or restrict any of the terms or provisions hereof. 

  
 12 

 IN WITNESS WHEREOF, the parties have caused this Supplemental Indenture to be duly executed as of
the date first written above. 
  

			
	LABORATORY CORPORATION OF AMERICA HOLDINGS
		
	By:	 	 /s/ F. Samuel Eberts III

		 	Name: F. Samuel Eberts III
		 	Title: Senior Vice President, Chief Legal Officer and Secretary

  

			
	U.S. BANK NATIONAL ASSOCIATION, Trustee
		
	By:	 	 /s/ Allison Lancaster-Poole

		 	Name: Allison Lancaster-Poole
		 	Title: Vice President

 [Signature Page to Twelfth Supplemental Indenture] 

 Exhibit A 

[FORM OF INITIAL NOTE] 
 EXCEPT AS OTHERWISE
PROVIDED IN SECTION 2.11 OF THE INDENTURE, THIS NOTE MAY BE TRANSFERRED, IN WHOLE BUT NOT IN PART, ONLY TO THE DEPOSITARY, ANOTHER NOMINEE OF THE DEPOSITARY OR TO A SUCCESSOR DEPOSITARY OR TO A NOMINEE OF SUCH SUCCESSOR DEPOSITARY 

CUSIP No. 50540R AU6 

ISIN No. US50540RAU68 
 No.
[1][2] 
 $[500,000,000][100,000,000] 

3.600% Senior Note due 2027 

Laboratory Corporation of America Holdings, a Delaware corporation, promises to pay to CEDE & CO., or registered assigns, the
principal amount set forth on Schedule I hereto on September 1, 2027. 
 Interest Payment Dates: March 1 and September 1,
commencing March 1, 2018. 
 Record Dates: February 15 and August 15. 

Additional provisions of this Note are set forth on the other side of this Note. 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

Dated: 
  

			
	LABORATORY CORPORATION OF AMERICA HOLDINGS
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

 

			
	U.S. Bank National Association, as Trustee, certifies that this is one of the Securities referred to in the Indenture.
		
	By:	 	  

		 	Authorized Signatory

 Dated: 

 [FORM OF REVERSE OF NOTE] 

3.600% Senior Note due 2027 
  

	1.	Indenture 

 This Note is one of a duly authorized series of debt securities of Laboratory
Corporation of America Holdings, a Delaware corporation (such corporation, and its successors and assigns under the Indenture hereinafter referred to, being herein called the “Company”), designated as the 3.600% Senior Notes due 2027 (the
“Notes”) issued under an Indenture dated as of November 19, 2010 (the “Base Indenture”), as supplemented by the Twelfth Supplemental Indenture dated August 22, 2017 (the “Supplemental Indenture,” and
collectively with the Base Indenture, the “Indenture”), between the Company and the Trustee. The terms of the Notes include those stated in the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939
as in effect on the date of the Indenture (the “Act”). Terms defined in the Indenture and not defined herein have the meanings ascribed thereto in the Indenture. The Notes are subject to all such terms, and Holders are referred to the
Indenture and the Act for a statement of those terms. 
 The Notes are general unsecured obligations of the Company. The Company shall be
entitled, without notice to or consent of the Holders, to issue additional debt securities under the Indenture on the same terms and conditions as the Notes (except for the interest accrual date and first Interest Payment Date) in accordance with
the Indenture. The Notes and any additional debt securities will be treated as a single series of debt securities for all purposes under the Indenture. The Indenture contains covenants that limit the ability of the Company and its Restricted
Subsidiaries to create Liens on assets and engage in Sale and Leaseback Transactions. The Indenture also contains a covenant that limits the ability of the Company’s Subsidiaries from incurring Indebtedness or issuing Preferred Stock. These
covenants are subject to important exceptions and qualifications. 
  

	2.	Interest 

 The Company promises to pay interest on the principal amount of this Note at the rate
per annum shown above. The Company shall pay interest semi-annually on March 1 and September 1 of each year, commencing March 1, 2018. Interest on the Notes shall accrue from the most recent date to which interest has been paid or, if
no interest has been paid, from August 22, 2017. Interest shall be computed on the basis of a 360-day year of twelve 30-day months. The Company shall pay interest on overdue principal at the rate borne by the Notes plus 1% per annum, and
it shall pay interest on overdue installments of interest at the same rate to the extent lawful. 
  

	3.	Method of Payment 

 The Company shall pay interest on the Notes (except Defaulted Interest) to
the Persons who are registered holders of Notes at the close of business on the February 15 or 

  
 4 

 
August 15 next preceding the Interest Payment Date even if the Notes are canceled after the record date and on or before the Interest Payment Date. Holders must surrender Notes to a Paying
Agent to collect principal payments. The Company shall pay principal and interest in money of the United States that at the time of payment is legal tender for payment of public and private debts. Payments in respect of the Notes represented by a
Global Security (including principal, premium and interest) will be made by wire transfer of immediately available funds to the accounts specified by The Depository Trust Company. The Company shall make all payments in respect of a certificated Note
(including principal, premium and interest) by mailing a check to the registered address of each Holder thereof; provided that payments on a certificated Note will be made by wire transfer to a U.S. dollar account maintained by the payee with a bank
in the United States if such Holder elects payment by wire transfer by giving written notice to the Trustee or the Paying Agent to such effect designating such account no later than 30 days immediately preceding the relevant due date for payment (or
such other date as the Trustee may accept in its discretion). 
  

	4.	Paying Agent and Security Registrar 

 Initially, U.S. Bank National Association, a national
banking association (the “Trustee”), will act as Paying Agent and Security Registrar. The Company may appoint and change any Paying Agent, Security Registrar or co-Security Registrar without notice. The Company or any of its domestically
incorporated wholly owned Subsidiaries may act as Paying Agent, Security Registrar or co-Security Registrar. 
  

	5.	Optional Redemption 

 In accordance with Section 3.01 of the Indenture, the Notes are
subject to redemption, in whole or in part, at any time, or from time to time, prior to June 1, 2027, at the option of the Company, at a redemption price equal to the greater of (1) 100% of the principal amount of the Notes being redeemed
plus accrued and unpaid interest to the redemption date or (2) the Make-Whole Amount for the Notes, which shall include a make-whole spread of 0.25%. 

On or after June 1, 2027, the Notes are subject to redemption, in whole or in part, at any time, or from time to time, at the option of
the Company, at a redemption price equal to 100% of the principal amount of the Notes being redeemed, plus accrued and unpaid interest to the redemption date. 

Notice of redemption will be mailed at least 30 days but not more than 60 days before the redemption date to each Holder of Notes to be
redeemed at his registered address. Notes in denominations larger than $1,000 principal amount may be redeemed in part but only in whole multiples of $1,000. If money sufficient to pay the redemption price of, which shall include accrued interest
on, all Notes (or portions thereof) to be redeemed on the redemption date is deposited with the Paying Agent on or before the redemption date and certain other conditions are satisfied, on and after such date interest ceases to accrue on such Notes
(or such portions thereof) called for redemption. 

  
 5 

	6.	Offer to Repurchase 

 If a Change of Control Repurchase Event occurs, unless the Company has
exercised its right to redeem the Notes as described in paragraph 5 of the Note, the Company shall make an offer to each Holder of Notes to repurchase all or any part (in multiples of $1,000 principal amount) of that Holder’s Notes at a
repurchase price in cash equal to 101% of the aggregate principal amount of Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to the date of purchase. Within 30 days following any Change of Control Repurchase Event or,
at the option of the Company, prior to any Change of Control, but after the public announcement of the Change of Control, the Company will mail a notice to each Holder describing the transaction or transactions that constitute or may constitute the
Change of Control Repurchase Event and offer to repurchase Notes on the payment date specified in the notice, which date shall be no earlier than 30 days and no later than 60 days from the date such notice is mailed. The notice shall, if mailed
prior to the date of consummation of the Change of Control, state that the offer to purchase is conditioned on the Change of Control Repurchase Event occurring on or prior to the payment date specified in the notice. The Company shall comply with
the requirements of Rule 14e-1 under the Securities Exchange Act of 1934 (the “Exchange Act”) and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the
repurchase of the Notes as a result of a Change of Control Repurchase Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control Repurchase Event provisions of this paragraph 6, the Company
will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the provisions of this paragraph 6 and all other provisions of the Indenture applicable to the Change of Control Repurchase
Event provisions of the Notes by virtue of such conflict. 
 On the Change of Control Repurchase Event payment date, the Company shall, to
the extent lawful: 
  

	 	i.	accept for payment all Notes or portions of Notes properly tendered pursuant to its offer; 

  

	 	ii.	deposit with the Paying Agent an amount equal to the aggregate purchase price in respect of all Notes or portions of Notes properly tendered; and 

 

	 	iii.	deliver or cause to be delivered to the Trustee the Notes properly accepted, together with an Officers’ Certificate stating the aggregate principal amount of Notes being purchased by the Company. 

The Paying Agent will promptly mail to each Holder of Notes properly tendered the purchase price for the Notes, and the Trustee will promptly
authenticate and mail (or cause to be transferred by book-entry) to each Holder a new note equal in principal amount to any unpurchased portion of any Notes surrendered; provided that each new note will be in a principal amount of $1,000 or an
integral multiple of $1,000 in excess thereof. 

  
 6 

 The Company shall not be required to make an offer to repurchase the Notes upon a Change of
Control Repurchase Event if a third party makes an offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and such third party purchases all Notes properly tendered and not withdrawn
under its offer. 
  

	 	(a)	For purposes of the foregoing: 

 “Below Investment Grade Rating Event” means the
Notes are rated below Investment Grade by both Rating Agencies on any date from the date of the public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the occurrence of
a Change of Control, which period shall be extended so long as the rating of the Notes is under publicly announced consideration for possible downgrade by either of the Rating Agencies. 

“Change of Control” means the occurrence of any of the following: 

 

	 	(a)	the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the properties or
assets of the Company and those of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other than the Company or a Subsidiary Guarantor that is a wholly owned Subsidiary
of the Company; 

  

	 	(b)	the adoption of a plan relating to the liquidation or dissolution of the Company; 

  

	 	(c)	the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act),
other than the Company or a Subsidiary Guarantor that is a wholly-owned Subsidiary of the Company, becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the
Voting Stock of the Company, measured by voting power rather than number of shares; or 

  

	 	(d)	the first day on which a majority of the members of the Board of Directors are not Continuing Directors. 

Notwithstanding the foregoing, a transaction effected to create a holding company for the Company will not be deemed to involve a Change of
Control if (1) pursuant to such transaction the Company becomes a wholly owned Subsidiary of such holding company and (2) the holders of the Voting Stock of such holding company immediately following such transaction are the same as the
holders of the Voting Stock of the Company immediately prior to such transaction. 

  
 7 

 “Change of Control Repurchase Event” means the occurrence of a Change of Control and a
Below Investment Grade Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member of the Board of
Directors who: 
  

	 	(a)	was a member of such Board of Directors on the first date that any of the Notes were issued; or 

  

	 	(b)	was nominated for election or elected to the Board of Directors with the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election.

 “Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) (or, in each case, if such Rating Agency ceases to rate the Notes for reasons outside of the Control of the Company, the
equivalent investment grade credit rating from any Rating Agency selected by the Company as a replacement Rating Agency). 

“Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s Corporation, and its successors. 

“Rating Agency” means: 
  

	 	(a)	each of Moody’s and S&P; and 

  

	 	(b)	if either of Moody’s or S&P ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons outside of the Control of the Company, a “nationally recognized statistical rating
organization” within the meaning of Section 3(a)(62) of the Exchange Act selected by the Company as a replacement agency for Moody’s or S&P, or both, as the case may be. 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and its successors.

 “Voting Stock”, as applied to stock of any Person, means shares, interests, participations or other equivalents in the equity
interest (however designated) in such Person having ordinary voting power for the election of a majority of the directors (or the equivalent) of such Person, other than shares, interests, participations or other equivalents having such power only by
reason of the occurrence of a contingency. 
  

	7.	Denominations; Transfer; Exchange 

 The Notes are in registered form without coupons in
denominations of one thousand U.S. dollars ($1,000) principal amount or any integral multiple thereof. A Holder may transfer or exchange Notes in accordance with the Indenture. The Security 

  
 8 

 
Registrar may require a Holder, among other things, to furnish appropriate endorsements or transfer documents and to pay any taxes or governmental charge in relation thereto or permitted by the
Indenture. The Company shall not be required (i) to issue, exchange or register the transfer of any Notes during a period beginning at the opening of business 15 days before the day of the mailing of a notice of redemption of less than all the
outstanding Notes of the same series and ending at the close of business on the day of such mailing, nor (ii) to register the transfer of or exchange any Notes of any series or portions thereof called for redemption. 

 

	8.	Persons Deemed Owners 

 The registered Holder of this Note may be treated as the owner of it for
all purposes. 
  

	9.	Unclaimed Money 

 Subject to any applicable abandoned property law, the Trustee and the Paying
Agent shall pay to the Company upon request any money held by them for the payment of principal or interest on the Notes that remains unclaimed for two years, and, thereafter, Securityholders entitled to the money must look to the Company for
payment as general creditors. 
  

	10.	Discharge and Defeasance 

 Subject to certain conditions, the Company at any time may terminate
some or all of its obligations under the Notes and the Indenture if the Company irrevocably deposits in trust with the Trustee money or Government Obligations for the payment of principal and interest on the Notes to redemption or maturity, as the
case may be and other conditions to defeasance are met. 
  

	11.	Amendment, Waiver 

 Subject to certain exceptions set forth in the Indenture, (i) the
Indenture with respect to the Notes and the Notes may be amended with the written consent of the Holders of not less than a majority in principal amount of the Notes outstanding and (ii) any default or noncompliance with any provision of the
Indenture with respect to the Notes may be waived with the written consent of the Holders of a majority in principal amount outstanding of the Notes. 

Subject to certain exceptions set forth in the Indenture, without the consent of any Securityholder, the Company and the Trustee shall be
entitled to amend the Indenture or the Notes to cure any ambiguity, defect or inconsistency, or to comply with Article V of the Base Indenture, or to provide for uncertificated Notes in addition to or in place of certificated Notes, or to add
additional covenants or to surrender rights and powers conferred on the Company or to add additional events of defaults or to add guarantees or to make any change that does not adversely affect the rights of any Securityholder in any material
respect or to provide for the issuance of a new series of debt securities under the Indenture or to evidence the appointment of a successor Trustee. 

  
 9 

	12.	Defaults and Remedies 

 Under the Indenture, Events of Default for the Notes include
(i) default for 30 days in payment of interest on the Notes; (ii) default in payment of principal on the Notes, upon redemption pursuant to paragraph 5 of the Notes, upon acceleration or otherwise; (iii) failure by the Company to
comply with other agreements in the Indenture or the Notes, in certain cases subject to notice and lapse of time; (iv) certain accelerations of other Indebtedness of the Company or any of its Subsidiaries if the amount accelerated (or so
unpaid) is at least $100.0 million; (v) failure by the Company or any Subsidiary to pay at maturity at least $100.0 million of other Indebtedness; and (vi) certain events of bankruptcy or insolvency with respect to the Company. 

Securityholders may not enforce the Indenture or the Notes except as provided in the Indenture. The Trustee may refuse to enforce the
Indenture or the Notes unless it receives indemnity or security satisfactory to it. Subject to certain limitations, Holders of a majority in principal amount of the Notes may direct the Trustee in its exercise of any trust or power with respect to
the Notes. The Trustee may withhold from Securityholders notice of any continuing Default (except a Default in payment of principal or interest) if it determines that withholding notice is in the interest of the Holders. 

 

	13.	Trustee Dealings with the Company 

 Subject to certain limitations imposed by the Act, the
Trustee in its individual or any other capacity may become the owner or pledgee of Notes and may otherwise deal with the Company or its Affiliates with the same rights it would have if it were not Trustee. 

 

	14.	No Recourse Against Others 

 An incorporator, stockholder, officer or director, as such, of the
Company or the Trustee shall not have any liability for any obligations of the Company under the Notes or the Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. By accepting a Note, each
Securityholder waives and releases all such liability. The waiver and release are part of the consideration for the issue of the Notes. 
  

	15.	Authentication 

 This Note shall not be valid until an authorized signatory of the Trustee (or
an Authenticating Agent) manually signs the certificate of authentication on the other side of this Note. 
  

	16.	Abbreviations 

 Customary abbreviations may be used in the name of a Securityholder or an
assignee, such as TEN COM (=tenants in common), TEN ENT (=tenants by the entireties), JT TEN (=joint tenants with rights of survivorship and not as tenants in common), CUST (=custodian), and U/G/M/A (=Uniform Gifts to Minors Act). 

  
 10 

	17.	CUSIP Numbers 

 Pursuant to a recommendation promulgated by the Committee on Uniform Security
Identification Procedures, the Company has caused CUSIP numbers to be printed on the Notes and has directed the Trustee to use CUSIP numbers in notices of redemption as a convenience to Securityholders. No representation is made as to the accuracy
of such numbers either as printed on the Notes or as contained in any notice of redemption and reliance may be placed only on the other identification numbers placed thereon. 
  

	18.	Governing Law 

 THIS NOTE SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF
THE STATE OF NEW YORK BUT WITHOUT GIVING EFFECT TO APPLICABLE PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY. 

  
 11 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
 I or we assign
and transfer this Note to 
 (Print or type assignee’s name, address and zip code) 

(Insert assignee’s soc. sec. or tax I.D. No.) 

and irrevocably appoint                agent to transfer this Note on the
books of the Company. The agent may substitute another to act for him. 
  

							
	
	  

	
	  

				
	Date:	  	  
	  	Your Signature:	  	  

	
	  

	
	  

 Sign exactly as your name appears on the face of this Note. 

  
 12 

 Option of Holder to Elect Purchase 

The undersigned elects to have this Note or the portion hereof (which is a multiple of $1,000 principal amount) designated below purchased by
the Company upon a Change of Control Repurchase Event pursuant to paragraph 6 on the reverse of this Note: 
  

					
	 Date:
	 	  
	  	
			
	 Your Signature:
	 	  
	  	
		
	 (Sign exactly as your name appears on the face of this Note)
	  	

					
			
	 Tax Identification No.:
	 	  
	 	
			
	 Signature Guarantee*:
	 	  
	 	

  

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 

Principal amount to be purchased (if less than all): $        ,000 

  
 13 

 LABORATORY CORPORATION OF AMERICA HOLDINGS 

3.600% SENIOR NOTE DUE 2027 
  

			
	No.	  	 Schedule I* 

  

					
	 Date
	  	 Principal amount of this
Global Note
	  	 Notation

		  	$	  	Original issuance

  

	*	To be attached to Global Note only. 

  
 14

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