Document:

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                                                                   EXHIBIT 10.16

                        RESEARCH COLLABORATION AGREEMENT

                                    BETWEEN

                             ARGONAUT TECHNOLOGIES

                                      AND

                           UNIVERSITY COLLEGE LONDON

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THIS AGREEMENT is made the 1st day of September 1999

BETWEEN:

ARGONAUT TECHNOLOGIES of 887 Industrial Road, Suite G, San Carlos, California
94070, USA

and

UNIVERSITY COLLEGE LONDON of Gower Street, London, WC1E 6BT, UK

BACKGROUND:

A)    Argonaut Technologies ("Argonaut") is a company specialising in the
      development of equipment and chemical processes in the field of parallel
      organic synthesis.

B)    The Wolfson Institute for Biomedical Research ("WIBR") is an Institute of
      University College London ("UCL") with expertise in the validation of
      potential drug targets and the development of lead molecules based
      thereon.

C)    Trident(TM) is an automated chemical library synthesis system developed
      and marketed by Argonaut.

D)    Argonaut and WIBR now wish to enter into a research collaboration whereby
      Argonaut places a Trident machine at WIBR laboratories and WIBR will
      perform method development and use the machine for its own and
      collaborative research projects in accordance with the following terms and
      conditions:

NOW IT IS HEREBY AGREED as follows:

1.    CONDITIONS AND INTERPRETATION

1.1   In this Agreement the following words and phrases shall have the following
      meanings, unless the context requires otherwise:

      "Affiliate"       means any person, organisation or entity, which is
                        directly or indirectly controlled by, controlling or
                        under common control with any Party. The term "control"
                        (including, with correlative meaning, the terms
                        "controlled by" and "under common control with") as used
                        with respect to any person

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                              or entity means the possession, directly or
                              indirectly, of the power to direct, or cause the
                              direction of, the management and policies of such
                              a person, organisation or entity, the ownership of
                              voting securities, or by contract, court order,
                              Statutory Instrument or otherwise. The ownership
                              of voting securities of a person, organisation or
                              entity, shall not, in itself, constitute "control"
                              for the purposes of this definition unless said
                              ownership is of a majority of the outstanding
                              securities entitled to vote of such a person,
                              organisation or entity.

"Agreement"                   means this agreement, as may be varied or
                              supplemented from time to time in accordance with
                              the provisions of this agreement.

"Commencement Date"           shall mean the date of the last signature below.

"Dedicated Employee"          the UCL employee funded by Argonaut under the
                              terms of this Agreement.

"Demonstration Visit"         shall mean occasions whereby a potential or
                              existing Argonaut client is brought to WIBR for
                              the purposes of discussing the Trident.

"Force Majeure"               means act of god, war, riot, civil commotion,
                              malicious damage, explosion, fire, flood, strike,
                              lock-out, shortage of materials or labour,
                              accident, breakdown of plant or machinery,
                              compliance with any law or governmental order,
                              rule, regulation or direction, or any other cause
                              beyond a Party's reasonable control.

"Method Development"          means any work specifically requested by Argonaut
                              to be carried out at WIBR to develop and/or
                              validate chemical processes. An Operating Plan
                              detailing the work to be undertaken, costs and
                              timescales will be agreed between the Parties
                              prior to commencing such Method Development.

"Party" or "Parties"          means Argonaut and/or UCL.

"Primary Demonstration        means where potential Argonaut client is brought
Visit"                        to WIBR to see the Trident in operation and
                              discuss its application with the Dedicated
                              Employee. Such a visit does not involve the
                              demonstration of client specified chemistry.

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"Secondary Demonstration Visit"    means where a potential Argonaut client is
                                   brought to WIBR to have client specified
                                   chemistry demonstrated on the Trident.

1.2  In this Agreement:

     1.2.1  unless the context otherwise requires, all references to a
            particular Clause shall be a reference to that clause in this
            Agreement, as may be amended from time to time pursuant to the terms
            hereof;

     1.2.2  the headings are inserted for convenience only and shall be ignored
            when construing this Agreement;

     1.2.3  unless the contrary intention appears, words importing the masculine
            gender shall include the feminine and vice versa and words in the
            singular include the plural and vice versa and words importing the
            whole shall be treated as including a reference to any part thereof;

     1.2.4  unless the contrary intention appears, words denoting persons shall
            include any individual, partnership, company, corporation, joint
            venture, trust, association, organisation or other entity, in each
            case whether or not having separate legal personality;

     1.2.5  reference to the words "include" or "including" are to be construed
            without limitation to the generality of the preceding words; and

     1.2.6  reference to any statute, statutory instrument or regulation
            includes any modification or re-enactment of that statute, statutory
            instrument or regulation.

2.   FUNDING

2.1  Argonaut will upon a date to be agreed between the Parties following the
     execution of this Agreement, arrange for delivery of one Trident to WIBR.
     Argonaut will be responsible for the costs of delivery and installation of
     the Trident;

2.2  Argonaut will pay for the cost of one full-time person, the "Dedicated
     Employee", employed at WIBR to operate the Trident and agree to pay an
     overhead charge on this UCL salary of [*] as set out in Annex 1;

[*] Confidential Treatment Requested

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2.3  Argonaut will in addition provide and pay for any training required by the
     Dedicated Employee in respect of operation and routine maintenance of the
     Trident;

2.4  Argonaut will reimburse UCL in full for the initial set-up costs of the
     Dedicated Employee up to a maximum of [*] ([*] pounds sterling), with
     items over [*] ([*] pounds sterling) itemised;

2.5  Argonaut will reimburse UCL in full for consumables used either during the
     setting up and testing of the Trident at WIBR or during any subsequent
     Method Development undertaken by WIBR in the course of this collaboration
     such costs not to exceed [*] per annum. UCL shall include in its quarterly
     invoice the pro rata amount of the [*] per annum consumable budget agreed
     as set out in Annex 1. On each anniversary of this Agreement, an audit of
     the actual consumable expenses incurred by UCL will be undertaken and any
     amount not spent of the annual budget will be deducted from the final
     quarter's invoice;

2.6  Argonaut will, at all times retain ownership of the Trident, subject to
     Clause 9.3, and will assume responsibility for the servicing and repair of
     the Trident throughout the term of this collaboration;

2.7  Where Demonstration Visits are arranged, subject to Clause 3 of this
     Agreement, Argonaut will fully reimburse UCL for any expenses incurred as a
     result of demonstrating the Trident or entertaining the visiting client;
     and

2.8  UCL will issue Argonaut with an invoice covering the payments due to UCL on
     a quarterly in arrears basis. Payments to UCL will be due no late than
     thirty (30) days from the date of the invoice.

3.   DEMONSTRATION VISITS

3.1  From time to time Argonaut, or an affiliate, may request that it is able to
     use the Trident situated at WIBR for the purposes of demonstrating the
     device to prospective Argonaut clients. Such visits shall be scheduled to
     occur between 09.00hrs and 1700hrs and UCL shall not unreasonably refuse
     such a request provided that:

     3.1.1  in the case of Primary Demonstration Visits, Argonaut shall give at
            least one (1) week's prior notice to WIBR staff, the visit shall not
            occupy more than 30 (thirty) minutes of the Dedicated Employee's
            time and there shall be no more than eight (8) such visits in any
            calendar month;

     3.1.2  in the case of Secondary Demonstration Visits, Argonaut shall give
            at least two (2) weeks' prior notice to WIBR staff, the visit shall
            not occupy more

[*] Confidential Treatment Requested

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                than one half of a working day on the machine or for the
                Dedicated Employee and there shall be no more than two (2) such
                visits during any calendar month; and

        3.1.3   Secondary Demonstration Visits, shall not be arranged when the
                Dedicated Employee plans to be absent from work. In the case of
                an unplanned absence, WIBR retains the right to cancel such a
                Demonstration Visit without liability.

4.   OWNERSHIP OF INTELLECTUAL PROPERTY

4.1  All intellectual property, whether patentable or not, that arises out of
     Method Development funded by Argonaut shall be the exclusive property of
     Argonaut and Argonaut grants UCL a royalty-free non-exclusive license to
     use such intellectual property.

     4.1.1  UCL shall notify at Argonaut as soon as practicable of any such
            intellectual property that arises whilst performing Method
            Development; and

     4.1.2  UCL shall, at Argonaut's expense, execute such documents. Powers
            of Attorney, grants of authority, assignments and licenses as
            Argonaut may request to give full force and effect to the provisions
            of this Clause and to enable Argonaut to record its interests in
            such property at the appropriate registries (worldwide).

     4.1.3  Should Argonaut elect not to seek protection of any such
            intellectual property but where UCL believes protection would be
            beneficial for UCL's business, UCL may, at its own expense and with
            the prior written approval of Argonaut, seek protection of any such
            intellectual property. Argonaut shall, at UCL's expense, execute
            all such documents, Powers of Attorney, grants of authority,
            assignments and licenses as Argonaut may request to give full force
            and effect to the provisions of this Clause and to enable UCL to
            record its interests in such property at the appropriate registries
            (worldwide).

     4.1.4  Where UCL proceeds to seek protection of intellectual property
            pursuant to Clause 4.1.3, UCL shall grant Argonaut a worldwide,
            royalty free license, without the right to sub-license, to use such
            technology for the purpose of conduction its own business.

4.2  All intellectual property arising from use of the Trident in WIBR's
     research programmes shall be the exclusive property of UCL, subject to the
     terms of any agreement governing sponsorship of that research programme.
     Argonaut waives

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     all right and future claim to any such intellectual property under the
     terms of this Agreement.

4.   RESTRICTIONS

5.1  During the term of this Agreement, WIBR shall not to enter into any other
     research collaboration within the field of development of enabling
     technology for parallel organic synthesis without the prior written
     permission of Argonaut.

6.   CONFIDENTIALITY

6.1  Except as otherwise permitted hereunder, each Party undertakes and agrees
     not at any time for any reason whatsoever to disclose or permit to be
     disclosed to any third party or otherwise make use of or permit to be made
     use of, any trade secrets or confidential information relating to the other
     Party's technology or the business affairs or finances of the other Party
     or of any affiliates, suppliers, agents, distributors, or customers of the
     Party which come into its possession pursuant to this Agreement. Such
     information should be clearly marked as "Confidential" and, if disclosed
     orally, subsequently reduced to writing within thirty (30) days and marked
     "Confidential".

6.2  Each Party shall ensure that all of its agents, employees who have access
     to the information referred to in Clause 6.1 are:

     6.2.1  made aware that such information is secret and confidential; and

     6.2.2  bound by undertakings of confidentiality (whether in their contracts
            of employment or otherwise) not to make any disclosure or use of
            such information but to keep the same confidential.

6.3  The obligations of confidence set out in this Clause 6 shall not extend to
     any information which:

     6.3.1  is, or shall become, generally available to the public otherwise
            than by reason of a breach of the recipient Party of the provisions
            of this Clause 8; or

     6.3.2  is known to the recipient Party and is at its free disposal prior to
            its receipt from the other Party, as can be shown by written record;
            or

     6.3.3  is subsequently disclosed to the recipient Party without obligations
            of confidence by a third party owing no such obligations in respect
            thereof; or

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        6.3.4   is required to be disclosed by any applicable law or any
                regulatory authority to which a Party is from time to time
                subject to; or

        6.3.5   is independently developed by a person or person with no access
                to the confidential information disclosed by a Party, as
                demonstrated by written records; or

        6.3.6   disclosed to a third party for whom you have had written
                permission from the discloser to pass the information to,
                subject to the third party undertaking obligations of
                confidence equivalent to those contained in this Agreement.

6.4     The obligations of each Party under this Clause 6 shall survive the
        expiration or termination of this Agreement for ten (10) years from the
        date of expiry or termination, as the case may be.

7.      PUBLICATION

7.1     Where UCL wishes to publish the results of Method Development performed
        UCL will be free to do so provided that:

        7.1.1   UCL have informed Argonaut in writing of the results to be
                disclosed not less than thirty (30) days prior to disclosure in
                order for Argonaut to evaluate whether any patent protection
                should be sought. Argonaut must inform UCL in writing within
                that thirty (30) day period if it wishes to seek such
                protection. In the absence of written notification UCL shall be
                free to publish;

        7.1.2   If Argonaut, at its sole discretion, decides patent protection
                is to be applied for, there shall be a further delay not to
                exceed forty-five (45) days during which Argonaut, at its own
                expense, may file appropriate patent application(s).

        7.1.3   Where the Trident has been successfully utilised in a WIBR
                research programme, Argonaut may, with the prior written
                permission of UCL, disclose statements relating to the generic
                use of the Trident in drug discovery for the purposes of
                marketing and promoting the Trident.

7.2     On all published articles referring to results involving the use of the
        Trident UCL agrees to acknowledge the use of the Trident in the research
        programme and the collaborative support of Argonaut.

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8.   TERM AND TERMINATION

8.1  This Agreement will commence on the first day of September 1999 and remain
     in force for two (2) years from the Commencement Date unless terminated
     pursuant to Clause 8, or extended pursuant to Clause 13.

8.2  Either Party (the "Terminating Party") shall have the right to terminate
     this Agreement forthwith upon giving written notice of termination to the
     other Party (the "Defaulting Party") upon the occurrence of any of the
     following events at any time during this Agreement:

     8.2.1     the Defaulting Party commits a material breach of this Agreement
               which in the case of a breach capable of remedy shall not have
               been remedied within sixty (60) days of the receipt by it of a
               notice identifying the breach and requiring its remedy;

     8.2.2     the Defaulting Party for a period of longer than sixty (60) days
               suspends payment of its debts or otherwise ceases or threatens to
               cease to carry on its business or becomes bankrupt or insolvent
               (including without limitation being deemed to be unable to pay
               its debts);

     8.2.3     a proposal is made or a nominee or supervisor is appointed for a
               composition in satisfaction of the debts of the Defaulting Party
               or a scheme or arrangement of its affairs, or the Defaulting
               Party enters into any composition or arrangement for the benefit
               of its creditors, or proceedings are commenced in relation to the
               Defaulting Party under any law, regulation or procedure relating
               to the re-construction or re-adjustment of debts (including where
               a petition is filed or proceeding commenced seeking any
               reorganisation, arrangement, composition, or re-adjustment under
               any applicable bankruptcy, insolvency, moratorium, reorganisation
               or other similar law affecting creditors rights or where the
               Defaulting Party consents to, or acquiesces in, the filing of
               such a petition);

     8.2.4     the Defaulting Party takes, without the consent of the
               Terminating Party (such consent not be unreasonably withheld),
               any action, or legal proceedings are started or other steps taken
               by a third party, with a view to:

               (a)  the winding up or dissolution of the Defaulting Party (other
                    than for the reconstruction of a solvent company for any
                    purpose, including the inclusion of any part of the share
                    capital of the Defaulting Party in any official stock
                    exchange listing or an application by the Defaulting Party
                    for registration as a public

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               company in accordance with the requirements of the Companies
               Act 1985); or

          (b)  the appointment of a liquidator, trustee, receiver,
               administrative receiver, receiver manager, interim receiver
               custodian, sequestrator or similar officer of the Defaulting
               Party against the Defaulting Party or a substantial part of the
               assets of the Defaulting Party, or anything analogous to any of
               the foregoing occurs under the laws of any country.

     8.3  Upon termination or expiry of this Agreement, UCL will have the
          option to purchase the Trident at a depreciated value, such
          depreciation deemed to be a linear depreciation over a four (4) year
          period commencing on the date of delivery of the Trident to WIBR in
          the Cruciform Building, thereafter the value of the Trident being
          written off.

     8.4  Upon termination or expiry of this Agreement, Argonaut will pay to
          UCL, within sixty (60) days, all sums owing which have accrued prior
          to the date of termination.

     8.5  Termination or expiry of this Agreement for whatever reason shall not
          affect the accrued rights of the Paries arising in any way out of
          this Agreement as at the date of termination and in particular the
          right to recover damages and interest, and the provisions of Clauses
          4, 6, 8, 11, 14 and 16 shall survive this Agreement and shall remain
          in full force and effect.

     9.   FORCE MAJEURE

     9.1  If UCL is unable to carry out any of its obligations under this
          Agreement due to Force Majeure this Agreement shall remain in effect
          but UCL's obligations under this Agreement and the obligations of
          Argonaut under this Agreement shall be suspended for a period equal
          to the duration of the circumstance of Force Majeure provided that:

          9.1.1     the suspension of UCL's performance is of not greater scope
                    or duration than is required by Force Majeure:

          9.1.2     UCL gives Argonaut as soon as practicable notice describing
                    the circumstance of the Force Majeure, including the nature
                    of the occurrence and its expected duration, and continues
                    to furnish regular reports to Argonaut during the period of
                    the Force Majeure;

          9.1.3     UCL uses all reasonable efforts to remedy its inability to
                    perform and to mitigate the effects of the circumstances of
                    Force Majeure; and

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        9.1.4   as soon as practicable after the event which constitutes Force
                Majeure the Parties shall discuss how best to progress the
                collaboration between them, as far as possible in accordance
                with this Agreement.

9.2     If Force Majeure continues for more than three (3) months from the
        first occurrence of the Force Majeure, either Party may give sixty (60)
        days written notice to the other Party to terminate this Agreement and
        termination shall occur if Force Majeure is still continuing at the end
        of that sixty (60) day notice period.

10.     GOVERNING LAW AND JURISDICTION

10.1    The validity, construction and performance of this Agreement shall be
        governed by the laws of England and be subject to the exclusive
        jurisdiction of the English courts.

11.     WAIVER

11.1    Neither Party shall be deemed to have waived any of its rights or
        remedies whatsoever unless the waiver is made in writing and signed by
        a duly authorised representative of that Party. In particular, no delay
        or failure of a Party in exercising or enforcing any of its rights or
        remedies whatsoever shall operate as a waiver of those rights or
        remedies so as to preclude or impair the exercise or enforcement of
        those rights or remedies nor shall any partial exercise or enforcement
        of that right or remedy by that Party.

12.     SEVERANCE OF TERMS

12.1    If the whole or any part of this Agreement is or becomes or is declared
        illegal, invalid or unenforceable in any jurisdiction for any reason
        (including both by reason of the provisions of any legislation and also
        by reason of any court which either has jurisdiction over this
        Agreement or has jurisdiction over any of the Parties):

        12.1.1  In the case of illegality, invalidity or un-enforceability of
                the whole of this Agreement it shall terminate only in
                relation to the jurisdiction in question; or

        12.1.2  in the case of the illegality, invalidity or un-enforceability
                of part of this Agreement that part shall be severed from this
                Agreement in the jurisdiction in question and that illegality,
                invalidity or un-enforceability

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          shall not in any way whatsoever prejudice or affect the remaining
          parts of this Agreement which shall continue in full force and effect.

12.2 If in the reasonable opinion of either Party any severance under this
     Clause 12 materially affects the commercial basis of this Agreement, the
     Parties shall discuss, in good faith, ways to eliminate the material
     effect.

13.  ENTIRE AGREEMENT AND VARIATIONS

13.1 This Agreement embodies and sets forth the entire agreement and
     understanding of the Parties and supersedes all prior oral or written
     agreements, understandings or arrangements relating to the specific
     subject matter of this Agreement. Neither Party shall be entitled to rely
     on any agreement, understanding or arrangement, which is not expressly set
     forth in this Agreement.

13.2 No director, officer, employee or agent of either Party is authorised to
     make any representation or warranty to the other Party not contained in
     this Agreement, and each party acknowledges that it has not relied on any
     such oral or written representation or warranties.

13.3 No variation, amendment, modification or supplement to this Agreement shall
     be valid unless made in writing in the English language and signed by a
     duly authorised representative of each Party.

14.  NOTICES

14.1 Any notice or other document to be given under this Agreement shall be in
     writing in the English language and shall be deemed to have been duly given
     if sent by fax, recorded mail or registered mail to a Party at the fax
     number or address set out below for such Party or such other address as the
     Party may from time to time designate by written notice to the other Party.

     Address of Argonaut

     Argonaut Technologies
     887 Industrial Road
     Suite G
     San Carlos
     California 94070
     USA

     For the attention of the David Binkley Ph.D
     Fax No. +1 650 598 1359

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      Address of WIBR

      Wolfson Institute for Biomedical Research
      University College London
      Gower Street
      London
      WC1E 6BT
      UK

      For the attention of Professor Ken Powell
      Fax No. +44 (0) 171 209 0470

      Any notices sent to WIBR shall be copied to UCLi, 2-16 Torrington Place,
      London, WC1E 7HN, UK (Fax No. 0171 209 0681) and marked for the attention
      of Mr I Chater.

14.2  Any notice given pursuant to this Clause 15 shall be deemed to have been
      received:

      14.2.1 in the case of sending by post, on the day five (5) days after the
      day of posting; or

      14.2.2 in the case of sending by fax at the time the sender's fax machine
      receives a clear transmission report.

15.   COSTS

15.1  Each Party shall bear its own legal costs, legal fees and other expenses
      incurred in the preparation and execution of this Agreement.

16.   PUBLIC STATEMENTS

16.1  Except as provided in Clause 16.2, neither Party shall, without the prior
      written consent of the other Party:

      16.1.1 use in advertising, publicly or otherwise, any trade name, personal
      name, trademark, trade device, symbol, or any abbreviation, contraction or
      simulation thereof, owned by that representing Party; or

      16.1.2 represent, either directly or indirectly, that any product or
      service of the other Party is a product or service of the representing
      Party or that it is

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               made in accordance with or utilises the information or documents
               of the other Party.

16.2  The restrictions in Clause 16.1 shall not apply to the following:

      16.2.1 a press release, in a form agreed to by the Parties, publicly
             announcing this Agreement; or

      16.2.2 use as required by any applicable law or governmental regulation.

17.   PARTNERSHIP

17.1  Nothing in this Agreement shall be construed as creating a partnership or
      joint venture between the Parties or constituting one Party as the agent
      of the other Party for any purpose whatsoever and neither Party shall have
      the authority or power to bind the other Party or to contract in the name
      of or create a liability against the other Party in any way or for any
      purpose.

18.   FURTHER ASSURANCE

18.1  Each Party shall do and execute or procure to be done and executed all
      necessary acts, deeds, documents and things that give full effect to this
      Agreement. Except as otherwise provided herein, the cost and expense of
      doing so shall be borne by the Party who is required to take such action.

IN WITNESS whereof this Agreement has been signed by duly authorised officers of
the Parties:

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Signed by: /s/ DAVID P. BINKLEY
           --------------------------
           For and on behalf of
           ARGONAUT TECHNOLOGIES INC.

Name:      David P. Binkley

Title:     President and CEO

Date:      September 1, 1999

Signed by: /s/ DRUSILLA KENNEY
           --------------------------
           For and on behalf of
           UNIVERSITY COLLEGE LONDON

Name:      Drusilla Kenney

Title:     Contracts Manager, UCL

Date:      2 October 1999

Acknowledged by: /s/ KEN POWELL
                 --------------------
                 For and on behalf of
                 WOLFSON INSTITUTE FOR BIOMEDICAL RESEARCH

Name:            Ken Powell

Title:           Deputy Director

Date:            12/10/99

Wolfson-Argonaut
09/02/99                               15
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                                    ANNEX 1

                                      [*]

[*] Confidential Treatment Requested

                                       16<PAGE>   1
                                                                   EXHIBIT 10.17

                         PURCHASE AND LICENSE AGREEMENT

     THIS IS AN AGREEMENT between Argonaut Technologies, Inc., a Delaware
corporation with an office at 887 Industrial Road, Suite G, San Carlos, CA 94070
("Vendor") and Zeneca Inc., a Delaware corporation with an office at 1800
Concord Pike, Wilmington, Delaware 19850-5437 ("Zeneca").

     WHEREAS, Vendor desires to sell Trident Automation Library System products
to Zeneca and license related software to Zeneca, and

     WHEREAS, Zeneca offers to purchase said Trident Automation Library System
products and obtain a license for such related software from Vendor.

     NOW, THEREFORE, this 30th day of September 1998, in consideration of the
terms and conditions recited herein, the parties hereby agree as follows.

                                   Article 1

Definitions

1.1    "Acceptance Date" means the date on which Vendor receives written notice
       from Zeneca that the System meets, and has been demonstrated to meet, the
       Specifications and that all Hardware, Software and Documentation have
       been received and are installed and operational. Such notice shall be on
       the form attached hereto as Exhibit A entitled "Notice of Acceptance
       Date", and no other communication of any sort will establish an
       Acceptance Date hereunder.

1.2    "Agreement" means this Agreement including any exhibits and amendments
       attached hereto.

1.3    "Delivery Date" shall mean the date which Vendor delivers the System to
       the Installation Location at Zeneca and all related Hardware, Software
       and Documentation, as described in Exhibit B hereto, have been received
       by Zeneca.

1.4    "Documentation" means the manuals, instructions and other materials,
       including but not limited to those supplied on paper or electric media
       (such as CD-ROM based media), related to the System and provided by
       Vendor to Zeneca hereunder.

1.5    "Effective Date" means the date upon which this Agreement is executed by
       the last party to execute such Agreement.

1.6    "Hardware" means the hardware components of the System listed in Exhibit
       B attached hereto and incorporated herein.

1.7    "Installation Location" means Room LW323 on the 3rd floor, Fairfax
       Research Center of the Zeneca facility at 1800 Concord Pike, Wilmington,
       Delaware, USA.

1.8    "Specifications" means the Specifications for the System, as set forth
       in Exhibit C.

1.9    "System" means the Trident Automation Library System comprising the
       Hardware, the Software and the Documentation described in Exhibit B
       hereto.

1.10   "Maintenance Agreement" means the maintenance agreement between the
       parties hereto covering the System, including but not limited to the
       Hardware and Software purchased under this

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       Agreement. The terms and conditions of said maintenance agreement, if
       Zeneca desires to purchase one, shall be determined at a later date.

1.11   "Purchase Price" constitutes payment for Hardware and Documentation and a
       license fee for related software.

1.12   "Software" means the software components of the System as listed in
       Exhibit B attached hereto and incorporated herein.

1.13   "Zeneca Group" - For purposes of this Agreement, Zeneca Group means
       Zeneca Inc., Zeneca Ltd. and Zeneca Group PLC; their respective direct
       and indirect parent companies, affiliates, and subsidiaries; their
       respective officers, directors, trustees, shareholders, employees and
       agents; and their respective predecessors, successors and assigns, heirs,
       executors and administrators.

                                   Article 2

Purchase and Sale

2.1    Purchase. Zeneca and Vendor hereby agree that, in return for the payment
       by Zeneca to Vendor of the Purchase Price and subject to the terms and
       conditions of this Agreement:

       (a)  Vendor shall sell, deliver and install, and Zeneca shall purchase
            and receive, the Hardware and Documentation; and

       (b)  Vendor hereby grants to Zeneca in conjunction with the sale of the
            Hardware, a perpetual, non-exclusive, paid-up, freely assignable
            license (the "License") to use and have used the Software, revocable
            only upon termination of this Agreement by Vendor or Zeneca. Zeneca
            shall notify Vendor in writing prior to any assignment.

2.2    Purchase Price.

       (a)  Zeneca and Vendor hereby agree that the Purchase Price is reflected
            in Exhibit G; and

       (b)  Vendor will offer Zeneca a discount of [*] if this Agreement is
            executed prior to September 30, 1998.

       (c)  Vendor will offer Zeneca a second discount of [*] if a second
            Trident System if ordered prior to September 30, 1998.

2.3    Payment Schedule. This Purchase Price shall be due and owing to Vendor
       according to the following schedule:

       Delivery Date:    [*] due within fifteen (15) days after delivery of
                         all components of the System.

       Acceptance Date:  [*] due within fifteen (15) days after Zeneca's
                         Acceptance of the System. Such acceptance shall not
                         exceed forty-five (45) days after successful completion
                         of installation.

[*] Confidential Treatment Requested

                                       2
<PAGE>   3
                                   Article 3

Shipment and Delivery

3.1  Shipment. Shipment of the System to the Installation Location shall be at
     Vendor's expense. Vendor shall be responsible for all cost, risk and
     expense in delivering to and installing the System at the Installation
     Location and any damage or harm to the System incurred as a result of
     shipment, delivery or installation shall be the responsibility of Vendor,
     (FOB Destination). Notwithstanding the foregoing, Vendor shall not be
     liable for damage or harm to the System incurred as a result of improper
     preparation or functioning of the Installation Location, or negligence or
     misconduct of Zeneca or its agents, employees.

3.2  Delivery. Delivery shall be completed on the following schedule:

     (a)  The System shall be delivered to Zeneca no later than [12] weeks from
          the Effective Date.

     (b)  Installation shall be started at the Installation Location no later
          than [2] week(s) after delivery of the System to Zeneca.

                                   Article 4

Installation and Acceptance

4.1  Installation. Zeneca shall prepare the Installation Location in accordance
     with the specifications set forth in Exhibit D. Modifications to the Zeneca
     facility to accommodate the delivery, installation and acceptance of the
     System shall be the responsibility of Zeneca. Such preparation shall be
     completed prior to delivery of the System. Vendor shall, at its own
     expense, install and take all action necessary to ensure the acceptance of
     the System at the Installation Location. Such installation and testing
     shall conform to the delivery schedule and acceptance procedures set forth
     herein. Zeneca shall reasonably cooperate with Vendor to provide access to
     facilities and personnel to ensure a timely installation and acceptance of
     the System.

     The System shall be installed by a qualified System Engineer to be selected
     by Vendor. As used herein, the term "System Engineer" shall mean an
     engineer qualified to test and install the System. To be eligible for
     Zeneca's installation, the System Engineer must have previous successful
     experience in field installations of Vendor's equipment.

     All services hereunder shall be performed during Zeneca's normal working
     hours between 8:15 am and 4:30 pm, Wilmington, Delaware local time, Monday
     through Friday, excluding Zeneca holidays unless otherwise agreed in
     writing by the parties. When installation of the System has been started by
     Vendor, installation shall proceed continuously during Zeneca's normal
     working hours until such installation is completed.

4.2  Delays. Time is of the essence in the Agreement.

                                   Article 5
Warranty

5.1  General. Vendor warrants that the System will conform to the Specifications
     set forth in Exhibit C upon the Acceptance Date and for the later of either
     twelve (12) months thereafter or December 31, 1999 ("the Initial Warranty
     Period").

                                       3
<PAGE>   4
5.2  Hardware Warranty.

     (a)  Vendor represents and warrants the Hardware against defects in
          material and workmanship for the Initial Warranty Period under normal
          use and service.

     (b)  Vendor will make the benefits of any other warranty covering the
          Hardware available to Zeneca.

     (c)  In the event that the Hardware displays or develops defects in
          material or workmanship during the Initial Warranty Period:

          (i)    Vendor shall attempt to remedy such defect by telephone. If
                 Vendor is unable to so remedy such defect within forty-eight
                 (48) hours of notice to Vendor by Zeneca of such defect, then
                 Vendor shall ensure that a qualified service engineer shall
                 arrive at the Installation Location within seventy-two (72)
                 hours of the end of such forty-eight (48) hour period.

          (ii)   Vendor shall provide repair or replacement of any defective
                 parts free of charge.

          (iii)  Vendor shall provide any necessary engineering services
                 required in connection with the repair or replacement of any
                 defective parts free of charge.

          (iv)   All other applicable rights and remedies shall be available to
                 Zeneca.

          (v)    After the Initial Warranty Period, Vendor shall maintain the
                 System as required by Zeneca through telephone support at no
                 charge or by on-site repair at installation Location under the
                 terms of a Maintenance Agreement.

     (d)  Vendor further agrees that one preventive maintenance visit for the
          System shall be scheduled at a time agreed by Zeneca during the
          Warranty Period.

     (e)  Vendor shall not be responsible under this warranty to the extent that
          defects with the Hardware are caused by misuse, abuse, or other fault
          attributable to Zeneca or its contractors.

5.2  Software Warranty.

     (a)  Vendor warrants that the Software as originally delivered and
          unaltered will, in conjunction with all other components of the
          System, materially perform the functions described in and operate in
          accordance with the Specifications and Documentation and contain no
          viruses or software locks. Vendor further warrants that the Software
          shall continue to meet all acceptance tests throughout the term of
          this Agreement.

     (b)  Vendor hereby represents and warrants to Zeneca that the Software
          licensed to Zeneca hereunder includes Software designed to insure year
          2000 compatibility, which shall specifically include the ability to
          correctly recognize, process, manage, manipulate and store millennial
          dates without affecting the integrity of data, output (including
          reports, screen contents, etc.) or interpretation, without
          interruption, and includes calculations that accommodate same century
          and multi-century formulas and date values, and date data interface
          values that reflect the century, without any errors relating to date,
          and that the Software will continue to be year 2000 compatible.

4

<PAGE>   5
      (c)    Vendor further represents and warrants that any modifications made
             by Vendor to the Software or services performed by Vendor in order
             to bring the Software into compliance with these representations
             and warranties does not and will not corrupt any data included in
             Zeneca's computer network and does not or will not contain any
             computer viruses or introduce a computer virus into Zeneca's
             computer network.

      (d)    In the event the Software does not meet any of the above
             representations and warranties, Vendor shall repair or replace
             such Software.

      (e)    Source Code and Source Code Materials. Vendor hereby grants to
             Zeneca and the Zeneca Group a fully-paid perpetual, non-exclusive,
             worldwide, limited license to use, modify, enhance and upgrade the
             Source Code and the Source Code Materials provided, however, that
             such license shall be exercisable solely in the event

             (i)    Vendor is unable, at any time during the Initial Warranty
                    Period specified in the Purchase and License Agreement to
                    correct any malfunction, defect or nonconformity in the
                    Software which prevents the Software from functioning in
                    accordance with the applicable Specifications.
                    Documentation, performance criteria and other warranties and
                    descriptions provided in this Agreement, within seven (7)
                    business days after Zeneca's notification to Vendor
                    specifying in reasonable detail in what aspects the Software
                    fails to conform; or

             (ii)   that the Vendor becomes insolvent, makes a general
                    assignment for the benefit of creditors, files a voluntary
                    petition of bankruptcy, suffers or permits the appointment
                    of a receiver for its business or assets, becomes subject to
                    any proceeding under any bankruptcy or insolvency law,
                    whether domestic or foreign, or has wound up or liquidated
                    its business voluntarily or otherwise and Zeneca has
                    compelling reasons to believe that such event(s) will cause
                    Vendor to fail to meet its warranty and maintenance
                    obligations in the foreseeable future. If such event should
                    occur, the source code will be delivered by the Vendor
                    within fifteen days of written request by Zeneca.

5.3   Third Party Rights.   Vendor warrants that the System to (including
      Hardware, Software and Documentation), and use thereof by Zeneca, does not
      violate any rights of any third party, including without limitation any
      patent, trademark, copyright, or service mark or constitute theft or
      misuse of a trade secret owned or controlled by a third party. Vendor
      warrants that for the Software it has ownership of or the right to
      distribute and license such Software. If claim is made with regard to
      Zeneca's use of the System. Vendor shall get permission for Zeneca to use
      such System.

5.4   Disclaimer.     EXCEPT AS SET FORTH IN THIS AGREEMENT, VENDOR MAKES NO
      WARRANTIES, WHETHER EXPRESS OR IMPLIED, OR STATUTORY REGARDING TO RELATING
      TO THE SYSTEM, HARDWARE, SOFTWARE, OR DOCUMENTATION, OR ANY MATERIALS OR
      SERVICES PROVIDED TO ZENECA UNDER THIS AGREEMENT. VENDOR SPECIFICALLY
      DISCLAIMS ALL IMPLIED WARRANTIES OF FITNESS FOR A PARTICULAR PURPOSE.

                                   Article 6

Indemnification.

6.1     Third Party Infringement. If notified promptly in writing of any action
      brought against Zeneca or the Zeneca Group alleging that Zeneca's sale,
      use or other disposition of the System (including

                                       5
<PAGE>   6
     Hardware and Software components and Documentation) infringes a patent,
     trademark, copyright or service mark or constitutes theft or misuse of a
     trade secret owned or controlled by a third party, Vendor shall defend that
     action at its expense and shall pay any costs and damages awarded against
     Zeneca in the action, including external attorney's fees and internal
     counsel expenses, provided that Vendor shall have control of the defense of
     any such action and all negotiations for its supplement or compromise, and
     provided further that no settlement will be made that is contrary to the
     best interests of Zeneca, as may reasonably be determined by Zeneca. If a
     final injunction is obtained in such action against Zeneca's use of the
     System, or any component thereof, or if in Vendor's opinion the System is
     likely to become the subject of a claim of infringement, Vendor shall, at
     its option and expense, either procure for Zeneca the right to continue
     using the System or any component thereof consistent with the purchase and
     licensing right accorded Zeneca herein, or replace or modify the System or
     any component thereof so that it becomes non-infringing (but is otherwise
     substantially identical to the originally provided System and is also
     suitable for Zeneca's intended uses), or grant Zeneca a credit for the
     infringing System or component thereof. Vendor shall not have any liability
     to Zeneca if the alleged infringement is caused by use or sale of the item
     in combination with other products or devices which are not furnished by
     Vendor.

6.2  Each party agrees to indemnify, defend and hold the other party harmless
     from and against any claim, demand, action, penalty, suit or liability
     (including the cost of defense, settlement, and external attorneys' fees
     and internal counsel expenses), which the other party may hereafter incur,
     become responsible for, or pay out as a result of death or bodily injuries
     to any person, destruction or damage to any property caused by

     (a)  the breach of any term, warranty, representation or provision of this
          Agreement, or

     (b)  in the case of Vendor, any failure to warn of damages or defects in
          the System or any component thereof.

     Notwithstanding the foregoing, either party shall not be obligated to
     indemnify or hold harmless the other party against any losses, claims or
     suits caused solely by the willful misconduct or negligence of the other
     party.

                                   Article 7
                                   ---------

Insurance.  Vendor shall at its own expense secure and maintain in full force
and effect throughout the term of the Agreement insurance coverage for (a)
Workmen's Compensation. (b) General Liability and (c) Automobile Liability in
amounts listed on Exhibit E. Certificates evidencing such insurance shall be
provided to Zeneca's Insurance Department.

                                   Article 8
                                   ---------

Ancillary Obligations

     8.1  System Changes. Zeneca is entitled to receive the most current and
          complete commercially released version of the System (including
          Hardware, Software and Documentation) available at the time of the
          Acceptance Date.

          Vendor shall promptly furnish to Zeneca any "bug" fixes (a "bug" is
          defined as something that prevents the Software from performing or
          meeting the Specifications) during the term of the license at no
          charge.

                                       6

<PAGE>   7
8.2  Software Upgrades/Updates. Commercially released updates to all Zeneca
     licensed Software modules shall be provided at no charge without limitation
     during the Initial Warranty Period. Vendor shall provide free support
     during the Initial Warranty Period. Future updates after the Initial
     Warranty Period may be purchased at Vendor's then listed price.

8.3  Computer Upgrades. Hardware required for enhanced performance may be
     purchased from Vendor at the time of purchase. Zeneca may choose to upgrade
     the original computer hardware equipment after the initial installation;
     costs and labor for upgraded equipment and connectivity to the system will
     be Zeneca's responsibility.

8.4  Site Inspection. Upon execution of this Agreement, Vendor shall make
     available a qualified engineer (at no additional charge) for the purpose of
     inspecting the Installation Location. The engineer shall conduct a series
     of standard measurements where required. If these measurements and the site
     facilities meet Vendor's site requirements, the engineer shall certify in
     writing on the form attached hereto as Exhibit F that the Installation
     Location is properly designed and equipped, and that the System will
     perform according to the Specifications (attached hereto as Exhibit C) and
     the Documentation in the environment. If the Installation Location does not
     meet Vendor's site requirements, the engineer shall make specific written
     recommendations to Zeneca's engineering and building operations staff as to
     how the Installation Location can be made to meet Vendor's site
     requirements and Zeneca shall promptly implement such recommendations. If
     multiple site inspection visits are necessary in order for the Installation
     Location to be certified, Vendor shall provide an engineer for such visits
     at Zeneca's expense. Installation cannot be started until a completed site
     acceptance form (Exhibit F) has been received by Zeneca. Commitment dates
     will be adjusted to allow for days lost due to site facilities being
     unavailable.

                                   Article 9

Documentation. Vendor shall supply one (1) printed copy and one (1) electronic
media copy of all Documentation for each component of the System as defined
herein.

                                   Article 10

Miscellaneous

     10.1      Taxes. The Purchase Price does not include any import duties.

     10.2      Termination. Termination of this Agreement shall occur in one of
               the following manners:

               a.   Termination by mutual agreement of the parties.

               (b)  Zeneca shall have the right to immediately terminate this
                    Agreement based upon Vendor's willful misconduct in
                    connection with services performed under this Agreement.
                    Willful misconduct shall include, but not be limited to,
                    disparagement of Zeneca or the Zeneca Group, as defined in
                    Paragraph 10.12 hereof, or their respective products,
                    services or management; unethical business conduct; unlawful
                    activities; failure to adhere to security, safety, health,
                    and environmental laws and regulations while on Zeneca's
                    premises; or breach of Vendor's obligations under paragraphs
                    5.1 and 5.2 herein and the Confidentiality Agreement signed
                    by Zeneca and Vendor dated herein. Such termination shall be
                    effective upon delivery of written notice to Vendor.

               (c)  Except as otherwise provided in paragraph 10.2(b), a party
                    shall have the right to terminate this Agreement based upon
                    the other party's non-performance or breach of any provision
                    of this Agreement. In such event, the non-breaching party
                    shall provide the

                                       7
<PAGE>   8
            breaching party with written notice of the reason for the
            non-breaching party's intention to terminate this Agreement and
            shall provide the breaching party within thirty (30) days to correct
            any non-performance or breach to the satisfaction of the
            non-breaching party.

            Except as otherwise provided herein, it is agreed and understood
            that termination of this Agreement for any reason whatsoever will
            result in a termination of Vendor's obligation to provide services
            to Zeneca pursuant to this Agreement and a termination of Zeneca's
            obligations to compensate Vendor pursuant to paragraph 2.2 as of
            the effective date of termination. The other terms of this
            Agreement shall survive the termination of the Agreement.

10.3   Exercise of Rights. Each party's termination of this Agreement pursuant
       to any of the foregoing provisions or exercise of its rights to relief
       as otherwise as set forth in this Agreement shall not be construed to
       limit such party's ability to pursue any other legal rights or claims it
       may have.

10.4   Entire Agreement. This Agreement, including any Exhibits thereto,
       constitutes the entire agreement among the parties and supersedes all
       understandings whether written or oral. The text of this Agreement shall
       control in case of any conflict with an Exhibit. Further modifications
       may be made if in writing and signed by all parties.

10.5   Controlling Law. The laws of the United States shall control and in
       particular, the internal laws of the State of Delaware without regard to
       its conflicts of law provisions.

10.6   Confidentiality.

       (a)  Each party acknowledges that it may have access to and obtain
            knowledge of certain proprietary and confidential information
            ("Confidential Information") of the other party disclosing such
            information (the "Discloser") in the course of its performance
            under this Agreement. Confidential Information shall not include
            information that: (i) was already in the possession of the party
            receiving Confidential Information ("Recipient") before disclosure
            thereof by Discloser to Recipient as evidenced by Recipient's
            written records, (ii) is independently developed by Recipient as
            evidenced by Recipient's written records, (iii) is or becomes
            publicly available through no fault of Recipient, or (iv) is
            obtained by Recipient from a third party under no obligation to
            disclose same.

       (b)  Recipient agrees to maintain in strictest confidence and to take
            all reasonable steps to maintain the confidentiality of the
            Confidential Information. Recipient also agrees not to disclose
            Confidential Information to any third party, and to use
            Confidential Information only to the extent needed to perform under
            this Agreement. Recipient recognizes that all documents and records
            received by Recipient from Discloser and all copies of such records
            and documents shall be Discloser's property exclusively. Recipient
            shall at all times keep all such documents, records and copies of
            documents and records in the Recipient's custody and subject to the
            Recipient's control and shall surrender the same upon request by
            Discloser.

10.7   Publications. Vendor agrees that it will not use the name of Zeneca or
       the names of any of its personnel for promotional literature,
       advertising, or any other reason without the prior written approval of
       Zeneca, provided that Vendor shall have the right to use the name of
       Zeneca in its customer list for the System and to distribute such list to
       third parties.

10.8   Other.

                                       8
<PAGE>   9
      (a)  Vendor shall supply a written list of factory and U.S. headquarters
           contact persons, phone numbers, Internet E-mail addresses and
           specialties for the Hardware and the Software at the time of delivery
           of the System.

      (b)  Vendor shall make available to Zeneca a twelve (12) month maintenance
           contract. Zeneca shall have the option to purchase this maintenance
           agreement at any time during the initial warranty period. See
           comments at Section 5.1(3)(e).

      (c)  Vendor shall provide five (5) consecutive days of training on the
           System on-site at Zeneca at the time of installation for up to three
           (3) people at no cost to Zeneca.

10.9  Counterparts. This Agreement may be signed in any number of counterparts,
      each of which shall be an original, with the same effects as if the
      signatures thereto were upon the same instrument.

10.10 Notices. All notices given under this Agreement shall be in writing and
      shall be delivered personally, sent by telegram or facsimile with return
      confirmation, or by first class United States mail, postage pre-paid to
      the parties at the following addresses:

          If to Zeneca:       Zeneca Inc.
                              1800 Concord Pike
                              Wilmington, DE 19850
                              Attn: Mike Climas
                              Telephone: (302)886-7975
                              Fax: (302)886-2909

          If to Vendor:       Argonaut Technologies, Inc.
                              887 Industrial Road, Suite G
                              San Carlos, CA 94070
                              Attn: Vice President of Sales & Services
                              Telephone: 650/598-1350
                              Fax: 650/598-1359

      Notices shall be effective when received.

10.11 Assignment. Neither party may assign or in any way make over any of its
      rights or duties under this Agreement without the prior written consent of
      the other party, except in the event of a sale of company equity or
      assets. Zeneca may assign any of its rights to any duties under this
      Agreement to any company controlled, controlling or under common control
      of Zeneca, in which event this Agreement shall be binding on and inure to
      the benefit of any successor or assignee of Zeneca. In the event of
      assignment, the assignor shall continue to be fully liable for any
      obligations under this Agreement.

10.12 Force Majeure. A party shall be excused from performing its obligations
      under this Agreement if its performance is delayed or prevented by any
      cause beyond such party's control and is without its fault or negligence,
      including but not limited to, acts of God, fire, explosion, weather,
      disease, war, insurrection, civil strife, riots, labor disputes,
      government action, including change in relevant government laws or
      regulations, or power failure. Performance shall be excused only to the
      extent of and during the reasonable continuance of such disability. Any
      deadline or time for performance specified that falls due during or
      subsequent to the occurrence of any of the disabilities referred to herein
      shall be automatically extended for a period of time equal to the period
      of such disability. Vendor shall immediately notify Zeneca if, by reason
      of any of the disabilities referred to herein. Vendor is unable to meet
      any deadline or time for performance.

                                       9
<PAGE>   10
IN NO EVENT SHALL EITHER PARTY BE LIABLE FOR ANY INDIRECT, INCIDENTAL, SPECIAL
OR CONSEQUENTIAL DAMAGES, OR DAMAGES FOR LOSS OF PROFITS, REVENUE, DATA OR USE,
INCURRED BY EITHER PARTY OR ANY THIRD PARTY, WHETHER IN AN ACTION IN CONTRACT
OR TORT, EVEN IF THE OTHER PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH
DAMAGES, VENDOR'S LIABILITY FOR DAMAGES HEREUNDER SHALL IN NO EVENT EXCEED THE
AMOUNT OF PAYMENTS PAID BY ZENECA UNDER THIS AGREEMENT EXCLUDING VENDOR'S
OBLIGATIONS UNDER SECTION 10.6. DAMAGES RELATING TO EITHER PARTY'S OBLIGATIONS
UNDER ALL OTHER SECTIONS, INCLUDING 6.1 AND 6.2 SHALL NOT EXCEED THE LIMITS OF
THEIR INSURANCE.

IN WITNESS WHEREOF the parties hereto have executed this Agreement on the day
and year last written below.

ZENECA, INC.                                 ARGONAUT TECHNOLOGIES

By: /s/ A.K. Willard                         By: /s/ Lissa A. Goldenstein
   ____________________________                  _______________________

Name: A.K. Willard                           Name: Lissa A. Goldenstein
      _________________________
         (Print)

Title: V.P. Biomedical Research              Title: V.P. Sales & Service
       ________________________

Date: 9 Nov. 1998                            Date: 10/30/98
       ________________________                    _____________________

                                       10

<PAGE>   11
                                   EXHIBIT A

                           NOTICE OF ACCEPTANCE DATE
                           _________________________

Date: _______________

Argonaut Technologies, Inc.
887 Industrial Road, Suite G
San Carlos, CA 94070
Attn: VP, Sales & Service

Dear _________:

Zeneca Inc. hereby notifies Argonaut Technologies that it has accepted the
System as that term is defined in the Purchase and License Agreement between
Zeneca Inc. and Argonaut Technologies, Inc. dated ____________, pursuant to the
terms thereof.

Zeneca Inc.

By: _________________

Title: ______________

Date: _______________

<PAGE>   12
                                   EXHIBIT B

               DESCRIPTION OF HARDWARE, SOFTWARE & DOCUMENTATION

1) 900132 Trident Automated Library Production Synthesizer

     consisting of; Trident main synthesizer system with two precision metered
     syringe systems, fluid delivery interface, reagent, solvent, waste
     connections, four (4) integrated agitation-thermal units, cabling.

2) Trident Ship Kit consisting of four (4) Trident Reaction Cassettes, 192
   Trident Reaction Vessel Assemblies, nine (9) 250 mL Reagent bottles, four (4)
   4 L Solvent carriers, two (2) 15 L HDPE waste reservoir, and spare parts.

3) 900136 Gilson 215 Autosampler/Sample Collector Upgrade

4) 900135 Trident Voltage Kit (USA)

5) 900131 Trident Computer System - HP

     Consisting of: Pentium 333 MHz processor, 64 Mbytes RAM, 6.4 Gbyte hard
     disk, 32x CDROM, microfloppy disk, 17" svga monitor, mouse/keyboard,
     Windows NT 4.0 and Microsoft OfficePro 97 supplied with Trident Control
     Software. Provided with 3 year HP warranty (1st year on site; 2nd & 3rd
     years return to HP.)

6) Trident Control Software provides software routines to define solvents/
   reagents and diversity reagents to be used in synthesis, definition of
   synthesis program based on fluid movements, program control, reaction times,
   and instrument control functions, solvent usage calculations, autosampler and
   sample collector control functions, and system monitors of programming,
   plumbing, and mechanical status. Provided on CD ROM.

<PAGE>   13

                                   EXHIBIT C

                                 SPECIFICATIONS

                     TRIDENT AUTOMATED LIBRARY SYNTHESIZER

                            INSTALLATION VALIDATION

The following document describes validation parameters for installation of the
Trident Automated Library Synthesizer. An instrument which demonstrates
adherence to these parameters is considered by Argonaut Technologies to be a
successfully installed, fully operational instrument capable of meeting all
published specifications, and one which demonstrates no damage in shipment.

SITE REQUIREMENTS

<TABLE>
<CAPTION>
Operational Requirement                 Specification                 Actual (Result)
<S>                                     <C>                           <C>
Lab temp                                18 degrees C to 25 degrees C

Lab humidity                            equal to or greater than
                                        70% RH

Recommended ventilation flow            Approx. 40 cfm
(with all doors closed)

Regulated N. pressure                   35 to 50 psi

Regulated He pressure                   15 psi

Regulated Compressed dry air            50 psi
pressure (or use N. gas)                Dryness equal to or less than
                                        0.01% H.O.

Line voltage/current capacity           Dedicated circuit, 200 to 240
                                        VAC @ 30 Amps
</TABLE>

ELECTRONIC INTEGRITY

SPECIFICATION:

All circuits working as designed. No connectors loose.

VALIDATION PROCEDURE:

Run pre-programmed automated procedure to exercise all valves and heaters.
Check runfile for valve or heater errors. Attach a copy of the runfile to
installation validation documentation.

RESULT:

(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

PLUMBING INTEGRITY

SPECIFICATION:

All pneumatic and liquid plumbing connects as per plumbing schematics. No loose
or leaking pneumatic fittings.

<PAGE>   14
VALIDATION PROCEDURE:

Check all fittings for tightness. Reconnect and/or tighten as necessary.

RESULT:

(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

INTERNAL LEAK/OBSTRUCTION CHECK

SPECIFICATION:

1.   No leaks or obstructions on pressure supply side (low, high and very low
     inputs).
2.   No leaks or obstructions in delivery/valving RV side.
3.   RVs hold pressure in cassette when sealed.

VALIDATION PROCEDURE:

1a)  Supply side: Perform a supply side pressure test to validate integrity of
     the gas input pneumatics. Verify no appreciable leaks.

1b)  Bottle leak test: Perform a bottle pressure test to validate integrity of
     bottle sealing and pressure system. Verify no appreciable leaks.

2    Perform a system leak test, checking for leaks or obstructions in all
     delivery pathways. Verify no obstructions or appreciable leaks.

3)   Perform a leak test on all 192 vessels of 4 cassettes. Verify no
     appreciable leaks.

RESULT:

(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

                                       14
<PAGE>   15
AS CALIBRATION

SPECIFICATION:
AutoSampler performs accurate and precise septa puncture and movement to the
needle wash ports.

VALIDATION PROCEDURE:
Perform an AutoSampler calibration verification procedure, utilizing a visual
verification of XYZ alignment with all vial positions and needle wash/waste
positions.

RESULT:
(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

HEATING

SPECIFICATION:
Rate: Ambient - 10 degrees Celsius to 90 degrees Celcius in 30 minutes
Rate: Ambient - 10 degrees Celsius to 150 degrees Celcius in 45 minutes
Accuracy: = 5 degrees Celcius or 5% of setpoint, whichever is greater

VALIDATION PROCEDURE:
Run the preprogrammed "Heating and Cooling Test". Check Runfile for time and
temperature readings in the heating ranges. Verify specifications are met.
Attach runfile to installation validation documentation.

RESULT:
(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

                                       15

<PAGE>   16
COOLING

SPECIFICATION:

Rate: Ambient -40 (degrees)C in 30 minutes
Rate: 150 (degrees)C to -40 (degrees)C in 30 minutes
Accuracy: + or (-) 5 (degrees)C or 5% of setpoint, whichever is greater

VALIDATION PROCEDURE:

Make sure a LN2 cryo tank, with sufficient capacity has been connected before
you run the above "Heating and Cooling test". After the run, check the runfile
for time and temperature readings in the cooling ranges. Verify specifications
are met. Attach runfile to installation validation documentation.

RESULT:

DIVERSITY REAGENT DELIVERY ACCURACY/PRECISION (AUTOSAMPLER)

SPECIFICATION:

Range: minimum 50 nanoliters to 3ml in 5 nanoliter increments
Accuracy: + or (-) 15 nanoliters ((less than)200 nanoliters): + or (-) 5%
((greater than)200 nanoliters)

VALIDATION PROCEDURE:

Run the preprogrammed "Solvent/Reagent Delivery Test" utilizing water or DMP in
the AutoSampler, Reagent and Solvent locations, and a cassette with 48 fully
prepared vials. Measure the volume in the collection vials which correspond to
AutoSampler deliveries using gravemetric determination, or transfer to a
graduated cylinder. All deliveries tested should be within the accuracy range.

RESULT:

(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

                                       16

<PAGE>   17
REAGENT DELIVERY ACCURACY/PRECISION (SMALL AND LARGE SYRINGE)

SPECIFICATION:

Range: minimum 50 nanoliters to 3 ml in 10 nanoliter increments
Accuracy: + or (-) 5%

VALIDATION PROCEDURE:

As above, run the preprogrammed "Solvent/Reagent Delivery Test" utilizing water
or DMF in the AutoSampler. Reagent and Solvent locations, and a cassette with
48 fully prepared vials. Measure the volume in the collection vials which
correspond to syringe deliveries using gravemetric determination, or transfer
to a graduated cylinder. All deliveries tested should be within the accuracy
range.

RESULT:

(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

AGITATION RATE VALIDATION

SPECIFICATION:

Rate: 0 to 400 strokes per minute
Accuracy: + or (-) 10%

VALIDATION PROCEDURE:

Using a tachometer, check the actual frequency of each agitator against the
programmed frequency at max speed (400 strokes per minute). Result should be
within the accuracy range for each agitator tested.

RESULT:

(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

SYSTEM INTEGRATION CHECK

SPECIFICATION:

All relevant modules perform as required in a pre-programmed system wide test
utilizing a typical solvent.

VALIDATION PROCEDURE:

Utilize results of "Solvent/Reagent Delivery Test" to validate system
integration check. Analyze runfile for errors. Attach a copy of the runfile to
the installation validation documentation.

RESULT:

(Argonaut Installation Engineer to enter result here and attach supporting
documentation)

                                       17
<PAGE>   18
                                   EXHIBIT D

                            SITE/SPACE REQUIREMENTS

INSTRUMENT COMPONENT DIMENSIONS

The following dimensions represent actual component dimensions. This information
will be useful for instrument clearances and weight support during transit.

<TABLE>
Component                               Height         Width          Length         Weight
<S>                                     <C>            <C>            <C>            <C>
Main Module (free standing on wheels)   57"            50.25"         63"            800 lbs
                                        144.8 cm       76.85 cm       160 cm
AutoSampler (215)
AutoSampler (223)
Syringe Module
</TABLE>

SYSTEM SPACE REQUIREMENTS

The following dimensions represent the requirements for placement of a
Trident(TM) and components in a laboratory, and take into account all
clearances needed for the entire Trident(TM) system.

HEIGHT

With model 215 AutoSampler and Syringe Module on top: 86" - 218.5 cm
With model 223 AutoSampler and Syringe Module on top:

WIDTH

With required rear clearance: 36" - 91.44 cm
With required rear clearance, solvent doors open in front: 55.5" - 141 cm

LENGTH

With side panel access on right side: 80.5" - 204.5 cm
With PC desk on right:
Length, with PC on Right, 230L dewar on left.
Length, with PC on right, 230L dewar and 50L solvent kegs(4) on right:

SPECIAL SPACE CONSIDERATIONS

EXTERNAL SOLVENT KEGS - External solvent kegs (up to 4) will need to be located
within several feet of the main module on the left side.

CRYO DEWAR - External cryo dewar used for chilling reactions will need to be
located within 4 feet of the main module to the left side

PC CONTROLLER - The PC controller can be located to the right or left side of
the Trident(TM) main module within several feet, and on a (user supplied) bench
or table. For each of operation, it is recommended to locate the PC to the right
of the instrument.
<PAGE>   19
                                   EXHIBIT E

                                   INSURANCE

Evidence of Insurance is attached and marked as Exhibit E.
<PAGE>   20
<TABLE>
<S>         <C>                                                         <C>

------------------------------------------------------------------------------------------------------------------------------------
ACORD(TM)     CERTIFICATE OF LIABILITY INSURANCE                                             DATE (MM/DD/YY)
                                                                                                09/22/98
------------------------------------------------------------------------------------------------------------------------------------
PRODUCER                                                                     THIS CERTIFICATE IS ISSUED AS A MATTER OF INFORMATION
ABD Technology                                                               ONLY AND CONFERS NO RIGHTS UPON THE CERTIFICATE
ALBURGER BASSO de GROSZ INS.                                                 HOLDER. THIS CERTIFICATE DOES NOT AMEND, EXTEND OR
301 Island Parkway, Suite 100                                                ALTER THE COVERAGE AFFORDED BY THE POLICIES BELOW.
Belmont, CA 94002                                                          ---------------------------------------------------------
                                                                                          INSURERS AFFORDING COVERAGE
------------------------------------------------------------------------------------------------------------------------------------
INSURED                                                                    INSURER A: St. Paul Fire & Marine
Argonaut Technologies                                                      ---------------------------------------------------------
887 Industrial Road, Ste G                                                 INSURER B: Fireman's Fund Insurance
San Carlos, CA 94070                                                       ---------------------------------------------------------
                                                                           INSURER C:
                                                                           ---------------------------------------------------------
                                                                           INSURER D:
                                                                           ---------------------------------------------------------
                                                                           INSURER E:
------------------------------------------------------------------------------------------------------------------------------------

COVERAGES
------------------------------------------------------------------------------------------------------------------------------------
THE POLICIES OF INSURANCE LISTED BELOW HAVE BEEN ISSUED TO THE INSURED NAMED ABOVE FOR THE POLICY PERIOD
INDICATED, NOTWITHSTANDING ANY REQUIREMENT, TERM OR CONDITION OF ANY CONTRACT OR OTHER DOCUMENT WITH RESPECT TO
WHICH THIS CERTIFICATE MAY BE ISSUED OR MAY PERTAIN. THE INSURANCE AFFORDED BY THE POLICIES DESCRIBED HEREIN IS
SUBJECT TO ALL THE TERMS, EXCLUSIONS AND CONDITIONS OF SUCH POLICIES. AGGREGATE LIMITS SHOWN MAY HAVE BEEN
REDUCED BY PAID CLAIMS.
<CAPTION>
                                                              POLICY        POLICY
                                                              EFFECTIVE     EXPIRATION
INSTR                                           POLICY        DATE          DATE
 LTR      TYPE OF INSURANCE                     NUMBER        (MM/DD/YY)    (MM/DD/YY)   LIMITS
------------------------------------------------------------------------------------------------------------------------------------
<S>       <C>                                   <C>           <C>           <C>            <C>                           <C>
  A       GENERAL LIABILITY                     TE01600570    01/01/98      01/01/99       EACH OCCURRENCE               $1,000,000
          [X] COMMERCIAL GENERAL LIABILITY                                                 ----------------------------------------
          [ ] [ ] CLAIMS MADE  [X] OCCUR                                                   FIRE DAMAGE (Any one fire)    $1,000,000
          [X] EMP. BENEFITS                                                                ----------------------------------------
          [ ] 1,000,000 LIMIT                                                              MED EXP (Any one person)      $10,000
          GENL AGGREGATE LIMIT APPLIES PER                                                 ----------------------------------------
          [ ] POLICY   [ ] PROJECT   [ ]  LOC                                              PERSONAL & ADV INJURY         $1,000,000
                                                                                           ----------------------------------------
                                                                                           GENERAL AGGREGATE             $2,000,000
                                                                                           ----------------------------------------
                                                                                           PRODUCTS-COMP/OP AGG          $2,000,000
------------------------------------------------------------------------------------------------------------------------------------
  A       AUTOMOBILE LIABILITY                  TE01600570    01/01/98      01/01/99       COMBINED SINGLE LIMIT
          [ ] ANY AUTO                                                                     (as accident)                 $1,000,000
          [ ] ALL OWNED AUTOS                                                              ----------------------------------------
          [ ] SCHEDULED AUTOS                   Hired Car Phy                              BODILY INJURY
          [X] HIRED AUTOS                       Damage                                     (Per person)                  $
          [X] NON-OWNED AUTOS                   Limit: ACV                                 ----------------------------------------
          [X] COMPREHENSIVE                     $1,000 DED.                                BODILY INJURY
          [X] COLLISION                         $1,000 DED.                                (Per accident)                $
                                                                                           ----------------------------------------
                                                                                            PROPERTY DAMAGE
                                                                                           (Per accident)                $
------------------------------------------------------------------------------------------------------------------------------------
          GARAGE LIABILITY                                                                 AUTO ONLY  -  EA ACCIDENT     $
          [ ] ANY AUTO                                                                     ----------------------------------------
          [ ]                                                                              OTHER THAN        EA ACC      $
                                                                                           AUTO ONLY:           AGG      $
------------------------------------------------------------------------------------------------------------------------------------
  A       EXCESS LIABILITY                      TE01600570    08/17/98      01/04/99       EACH OCCURRENCE               $1,000,000
          [X] OCCUR  [ ] CLAIMS MADE                                                       AGGREGATE                     $1,000,000
          [ ]                                                                                                            $
          [ ] DEDUCTIBLE                                                                                                 $
          [X] RETENTION $10,000                                                                                          $
------------------------------------------------------------------------------------------------------------------------------------
  B       WORKERS COMPENSATION AND              WZC80761613   01/04/98      01/04/99       X WC STATU-            OTH-
          EMPLOYERS' LIABILITY                                                               TORY LIMITS           ER
                                                                                           E.L. EACH ACCIDENT            $1,000,000
                                                                                           E.L. DISEASE EA EMPLOYEE      $1,000,000
                                                                                           E.L. DISEASE - POLICY LIMIT   $1,000,000
------------------------------------------------------------------------------------------------------------------------------------
  A       OTHER Blanket                         TE01600570    01/01/98      01/01/99       $1,000 Deductible
          Pers. Property                                                                   $2,700,000 Limit
          Blanket EDP                                                                      $899,800 Limit
------------------------------------------------------------------------------------------------------------------------------------
DESCRIPTION OF OPERATIONS/LOCATIONS/VEHICLES/EXCLUSIONS ADDED BY ENDORSEMENT/SPECIAL PROVISIONS
Replacement Cost and Special Form incl Theft applies to Property Coverage.
Transit Limit: $60,000; Exhibition Limit: $60,000; AOL Limit:$71,000
Business Income Limit: $5,590,000; Off Premises Power Limit: $1,000,000
Employee Dishonesty Limit: $60,000 - Deductible $1,000

------------------------------------------------------------------------------------------------------------------------------------
CERTIFICATE HOLDER   ADDITIONAL INSURED: INSURER LETTER     CANCELLATION Ten Day Notice for Non-Payment
------------------------------------------------------------------------------------------------------------------------------------
                                                            SHOULD ANY OF THE ABOVE DESCRIBED POLICIES BE CANCELLED BEFORE THE
Argonaut Technologies, Inc.                                 EXPIRATION DATE THEREOF, THE ISSUING INSURER WILL ENDEAVOR TO MAIL 30
887 Industrial Road, Suite G                                DAYS WRITTEN NOTICE TO THE CERTIFICATE HOLDER NAMED TO THE LEFT, BUT
San Carlos, CA 94070                                        FAILURE TO DO SO SHALL IMPOSE NO OBLIGATION OR LIABILITY OF ANY KIND
                                                            UPON THE INSURER, ITS AGENTS OR REPRESENTATIVES.
                                                            ------------------------------------------------------------------------
                                                            AUTHORIZED REPRESENTATIVE

                                                            (illegible)
------------------------------------------------------------------------------------------------------------------------------------
ACORD 25-5 (7/97) 1 OF 2 #S117584/M117570                                                            MAB  (R) ACORD CORPORATION 1985

</TABLE>

<PAGE>   21
<TABLE>
<S>         <C>                                                         <C>

------------------------------------------------------------------------------------------------------------------------------------
ACORD(TM)     CERTIFICATE OF LIABILITY INSURANCE                                             DATE (MM/DD/YY)
                                                                                                09/22/98
------------------------------------------------------------------------------------------------------------------------------------
PRODUCER                                                                     THIS CERTIFICATE IS ISSUED AS A MATTER OF INFORMATION
ABD Technology                                                               ONLY AND CONFERS NO RIGHTS UPON THE CERTIFICATE
ALBURGER BASSO de GROSZ INS.                                                 HOLDER. THIS CERTIFICATE DOES NOT AMEND, EXTEND OR
301 Island Parkway, Suite 100                                                ALTER THE COVERAGE AFFORDED BY THE POLICIES BELOW.
Belmont, CA 94002                                                          ---------------------------------------------------------
                                                                                          INSURERS AFFORDING COVERAGE
------------------------------------------------------------------------------------------------------------------------------------
INSURED                                                                    INSURER A: St. Paul Fire & Marine
Argonaut Technologies                                                      ---------------------------------------------------------
887 Industrial Road, Ste G                                                 INSURER B:
San Carlos, CA 94070                                                       ---------------------------------------------------------
                                                                           INSURER C:
                                                                           ---------------------------------------------------------
                                                                           INSURER D:
                                                                           ---------------------------------------------------------
                                                                           INSURER E:
------------------------------------------------------------------------------------------------------------------------------------

COVERAGES
------------------------------------------------------------------------------------------------------------------------------------
THE POLICIES OF INSURANCE LISTED BELOW HAVE BEEN ISSUED TO THE INSURED NAMED ABOVE FOR THE POLICY PERIOD
INDICATED, NOTWITHSTANDING ANY REQUIREMENT, TERM OR CONDITION OF ANY CONTRACT OR OTHER DOCUMENT WITH RESPECT TO
WHICH THIS CERTIFICATE MAY BE ISSUED OR MAY PERTAIN. THE INSURANCE AFFORDED BY THE POLICIES DESCRIBED HEREIN IS
SUBJECT TO ALL THE TERMS, EXCLUSIONS AND CONDITIONS OF SUCH POLICIES. AGGREGATE LIMITS SHOWN MAY HAVE BEEN
REDUCED BY PAID CLAIMS.
<CAPTION>
                                                              POLICY        POLICY
                                                              EFFECTIVE     EXPIRATION
INSTR                                           POLICY        DATE          DATE
 LTR      TYPE OF INSURANCE                     NUMBER        (MM/DD/YY)    (MM/DD/YY)   LIMITS
------------------------------------------------------------------------------------------------------------------------------------
  A       GENERAL LIABILITY                     TE01600604    01/01/98      01/01/99       EACH OCCURRENCE               $1,000,000
          [X] COMMERCIAL GENERAL LIABILITY                                                 ----------------------------------------
          [ ] [ ] CLAIMS MADE  [X] OCCUR        Foreign                                    FIRE DAMAGE (Any one fire)    $1,000,000
          [ ]                                  Liability                                  ----------------------------------------
          [ ]                                                                              MED EXP (Any one person)      $10,000
          GENL AGGREGATE LIMIT APPLIES PER                                                 ----------------------------------------
          [ ] POLICY   [ ] PROJECT   [ ]  LOC                                              PERSONAL & ADV INJURY         $1,000,000
                                                                                           ----------------------------------------
                                                                                           GENERAL AGGREGATE             $2,000,000
                                                                                           ----------------------------------------
                                                                                           PRODUCTS-COMP/OP AGG          $2,000,000
------------------------------------------------------------------------------------------------------------------------------------
  A       AUTOMOBILE LIABILITY                  TE01600604    01/01/98      01/01/99       COMBINED SINGLE LIMIT
          [ ] ANY AUTO                                                                     (as accident)                 $1,000,000
          [ ] ALL OWNED AUTOS                                                              ----------------------------------------
          [ ] SCHEDULED AUTOS                                                              BODILY INJURY
          [ ] HIRED AUTOS                                                                  (Per person)                  $
          [X] NON-OWNED AUTOS                                                              ----------------------------------------
          [ ]                                   Foreign Auto                               BODILY INJURY
          [ ]                                   DIC/Excess                                 (Per accident)                $
                                                                                           ----------------------------------------
                                                                                           PROPERTY DAMAGE
                                                                                           (Per accident)                $
------------------------------------------------------------------------------------------------------------------------------------
          GARAGE LIABILITY                                                                 AUTO ONLY  -  EA ACCIDENT     $
          [ ] ANY AUTO                                                                     ----------------------------------------
          [ ]                                                                              OTHER THAN        EA. ACC.    $
                                                                                           AUTO ONLY:            AGG     $
------------------------------------------------------------------------------------------------------------------------------------
          EXCESS LIABILITY                                                                 EACH OCCURRENCE               $
          [ ] OCCUR  [ ] CLAIMS MADE                                                       AGGREGATE                     $
          [ ]                                                                                                            $
          [ ] DEDUCTIBLE                                                                                                 $
          [ ] RETENTION $                                                                                                $
------------------------------------------------------------------------------------------------------------------------------------
  A       WORKER'S COMPENSATION AND             TE01600604    01/01/98      01/01/99         WC STATU-            OTH-
          EMPLOYERS' LIABILITY                  Foreign Vol.                                 TORY LIMITS           ER
                                                Compensation                               E.L. EACH ACCIDENT            $1,000,000
                                                                                           E.L. DISEASE EA EMPLOYEE      $1,000,000
                                                                                           E.L. DISEASE - POLICY LIMIT   $1,000,000
------------------------------------------------------------------------------------------------------------------------------------
          OTHER
------------------------------------------------------------------------------------------------------------------------------------
DESCRIPTION OF OPERATIONS/LOCATIONS/VEHICLES/EXCLUSIONS ADDED BY ENDORSEMENT/SPECIAL PROVISIONS

------------------------------------------------------------------------------------------------------------------------------------
CERTIFICATE HOLDER   ADDITIONAL INSURED: INSURER LETTER     CANCELLATION Ten Day Notice for Non-Payment
------------------------------------------------------------------------------------------------------------------------------------
                                                            SHOULD ANY OF THE ABOVE DESCRIBED POLICIES BE CANCELLED BEFORE THE
Argonaut Technologies, Inc.                                 EXPIRATION DATE THEREOF, THE ISSUING INSURER WILL ENDEAVOR TO MAIL 30
887 Industrial Road, Suite G                                DAYS WRITTEN NOTICE TO THE CERTIFICATE HOLDER NAMED TO THE LEFT, BUT
San Carlos, CA 94070                                        FAILURE TO DO SO SHALL IMPOSE NO OBLIGATION OR LIABILITY OF ANY KIND
                                                            UPON THE INSURER, ITS AGENTS OR REPRESENTATIVES.
                                                            ------------------------------------------------------------------------
                                                            AUTHORIZED REPRESENTATIVE

                                                            (illegible)
------------------------------------------------------------------------------------------------------------------------------------
ACORD 25-5 (7/97) 1 OF 2 #S117602/M117598                                                            MAB  (R) ACORD CORPORATION 1985

</TABLE>
<PAGE>   22
                                   IMPORTANT

If the certificate holder is an ADDITIONAL INSURED, the policy(ies) must be
endorsed. A statement on this certificate does not confer rights to the
certificate holder in lieu of such endorsement(s).

If SUBROGATION IS WAIVED, subject to the terms and conditions of the policy,
certain policies may require an endorsement. A statement on this certificate
does not confer rights to the certificate holder in lieu of such endorsement(s).

                                   DISCLAIMER

The Certificate of Insurance on the reverse side of this form does not
constitute a contract between the issuing Insurer(s), authorized representative
or producer, and the certificate holder, nor does it affirmatively or
negatively amend, extend or alter the coverage afforded by the policies listed
thereon.

<PAGE>   23
                                   IMPORTANT

If the certificate holder is an ADDITIONAL INSURED, the policy(ies) must be
endorsed. A statement on this certificate does not confer rights to the
certificate holder in lieu of such endorsement(s).

If SUBROGATION IS WAIVED, subject to the terms and conditions of the policy,
certain policies may require an endorsement. A statement on this certificate
does not confer rights to the certificate holder in lieu of such endorsement(s).

                                   DISCLAIMER

The Certificate of Insurance on the reverse side of this form does not
constitute a contract between the issuing Insurer(s), authorized representative
or producer, and the certificate holder, nor does it affirmatively or
negatively amend, extend or alter the coverage afforded by the policies listed
thereon.
<PAGE>   24
                                   EXHIBIT F

                              SITE ACCEPTANCE FORM

Date: _______________________________

Ms. Heather Corcoran
Logistics and Safety - Purchasing
Zeneca, Inc.
1800 Concord Pike
Wilmington, DE 19850

Dear Heather:

Argonaut Technologies, Inc. hereby notifies Zeneca Inc. that it has accepted the
Installation Location, as that term is defined in the Purchase and License
Agreement between Argonaut and Zeneca Inc., dated _______________________, as
acceptable, in its present condition, for installation of the System, as defined
in the Agreement, pursuant to the terms hereof.

_____________________________________

By: _________________________________

Title: ______________________________

Date: _______________________________
<PAGE>   25
                                   EXHIBIT G

                                Proposed Price.
                      (ATTACH FINAL QUOTE FROM ARGONAUT).

                                       21

<PAGE>   26
[ARGONAUT      887 INDUSTRIAL ROAD, SUITE G
TECHNOLOGIES   SAN CARLOS, CA 94070
LOGO]          (650) 598-1350
               FAX (650) 598-1359

<TABLE>
<S>                 <C>               <C>    <C>       <C>               <C>                 <C>
                                      ----------------------------------------------------------------------------------------------
                                      SALES ORDER      SALES ORDER ID   ORDER DATE           ORDER TYPE
                                                       004737           09/29/98             NORMAL
                                      ----------------------------------------------------------------------------------------------
                                      PAGE   CHG NO.   CHANGE DATE      CHANGE DESCRIPTION   CONFIRMED TO
                                      1         1      10/19/98                              HEATHER CORCORAN
                                      ----------------------------------------------------------------------------------------------
                                      CURRENCY         TERMS                                 REFERENCE
                                      USD              NET 15 DAYS
-----------------------------------   ----------------------------------------------------------------------------------------------
CUSTOMER P.O. NO.   ATTENTION         SHIP VIA                          FOB                  FREIGHT TERMS
35047660            MIKE KLIMAS       BEST WAY                          DESTINATION          NO CHARGE
-----------------------------------   ----------------------------------------------------------------------------------------------
SOLD TO PHONE NO.   SOLD TO FAX NO.   RESALE NO.                                                              TAX CODE
302-886-2857        302-886-2909      DE HAS NO STATE TAX                                    T = TAXABLE  R = RESALE  N = NONTAXABLE
-----------------------------------   ----------------------------------------------------------------------------------------------
</TABLE>

<TABLE>
<S>   <C>                      <C>   <C>                        <C>   <C>
S     ZENEC002                 S     ZENEC002                   B     ZENEC$02
O     ZENECA PHARMACEUTICALS   H     ZENECA PHARMACEUTICALS     I     ZENECA PHARMACEUTICALS
L     FAIRFAX RESEARCH CENTER  I     FAIRFAX RESEARCH CENTER    L     ATTN: ACCOUNTS PAYABLE FOC 2C
D     1800 CONCORD PIKE        P     1800 CONCORD PIKE          L     PO BOX 15437
      WILMINGTON DE 19803            WILMINGTON, DE                   WILMINGTON, DE
T     USA                      T     USA 19803                  T     USA 19850-5437
O                              O                                O
</TABLE>

<TABLE>
<S>    <C>                                      <C>         <C>              <C>   <C>              <C>     <C>      <C>
------------------------------------------------------------------------------------------------------------------------------------
LINE                 DESCRIPTION                 REQUEST/   ORDER QUANTITY   U/M     UNIT PRICE     PRICE       TAX CODE
       PART ID                                  SCHEDULED     BALANCE DUE          EXTENDED PRICE    CODE   DISC %   VAT CODE
       CUSTOMER PART ID      DWD REV      ECN   SHIP DATE
------------------------------------------------------------------------------------------------------------------------------------
1.00   TRIDENT AUTOMATED LIBRARY SYNTHESIZER     10/29/98          1          EA      [*]             LP    N
         900132                                  10/29/98          1                        [*]

2.00   TRIDENT AUTOSAMPLER UPGRADE-GILSON 215    10/29/98          1          EA      [*]             LP    N
         900136                    2             10/29/98          1                        [*]

3.00   TRIDENT VOLTAGE KIT, NORTH AMERICA        10/29/98          1          EA      [*]             LP    N
         900135                                  10/29/98          1                        [*]

4.00   WORKSTATION, SYS, HEWLETT PACKARD         10/29/98          1          EA      [*]             LP    N
         900133                      A           10/29/98          1                        [*]

             Customer will received an HP
             computer on this order.

5.00   ONE-TIME PRODUCT DISCOUNT                 10/29/98          1          EA      [*]             LP    N
                                                 10/29/98          1                        [*]
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>
<TABLE>
<S>            <C>       <C>      <C>   <C>                <C>                  <C>                  <C>         <C>
SUBTOTAL                                ORDER TAX AMOUNT   ORDER TAX AMOUNT 2   ORDER TAX AMOUNT 3   ORDER VAT   ORDER TOTAL

------------------------------------------------------------------------------------------------------------------------------------
ORDER TAKER   SALESMAN   REGION
    CY          SV        AMR     3                  Customer                                                 CONTINUED NEXT PAGE
--------------------------------------
</TABLE>

[*] Confidential Treatment Requested
<PAGE>   27
[ARGONAUT      887 INDUSTRIAL ROAD, SUITE G
TECHNOLOGIES   SAN CARLOS, CA 94070
LOGO]          (650) 598-1350
               FAX (650) 598-1359

<TABLE>
<S>                 <C>               <C>    <C>       <C>               <C>                 <C>
                                      ----------------------------------------------------------------------------------------------
                                      SALES ORDER      SALES ORDER ID   ORDER DATE           ORDER TYPE
                                                       004737           09/29/98             NORMAL
                                      ----------------------------------------------------------------------------------------------
                                      PAGE   CHG NO.   CHANGE DATE      CHANGE DESCRIPTION   CONFIRMED TO
                                      2         1      10/19/98                              HEATHER CORCORAN
                                      ----------------------------------------------------------------------------------------------
                                      CURRENCY         TERMS                                 REFERENCE
                                      USD              NET 15 DAYS
-----------------------------------   ----------------------------------------------------------------------------------------------
CUSTOMER P.O. NO.   ATTENTION         SHIP VIA                          FOB                  FREIGHT TERMS
35047660            MIKE KLIMAS       BEST WAY                          DESTINATION          NO CHARGE
-----------------------------------   ----------------------------------------------------------------------------------------------
SOLD TO PHONE NO.   SOLD TO FAX NO.   RESALE NO.                                                              TAX CODE
302-886-2857        302-886-2909      DE HAS NO STATE TAX                                    T = TAXABLE  R = RESALE  N = NONTAXABLE
-----------------------------------   ----------------------------------------------------------------------------------------------
</TABLE>

<TABLE>
<S>   <C>                      <C>   <C>                        <C>   <C>
S     ZENEC002                 S     ZENEC002                   B     ZENEC$02
O     ZENECA PHARMACEUTICALS   H     ZENECA PHARMACEUTICALS     I     ZENECA PHARMACEUTICALS
L     FAIRFAX RESEARCH CENTER  I     FAIRFAX RESEARCH CENTER    L     ATTN: ACCOUNTS PAYABLE FOC 2C
D     1800 CONCORD PIKE        P     1800 CONCORD PIKE          L     PO BOX 15437
      WILMINGTON DE 19803            WILMINGTON, DE                   WILMINGTON, DE
T     USA                      T     USA 19803                  T     USA 19850-5437
O                              O                                O
</TABLE>

<TABLE>
<S>    <C>                                      <C>         <C>              <C>   <C>              <C>     <C>      <C>
------------------------------------------------------------------------------------------------------------------------------------
LINE                 DESCRIPTION                 REQUEST/   ORDER QUANTITY   U/M     UNIT PRICE     PRICE       TAX CODE
       PART ID                                  SCHEDULED     BALANCE DUE          EXTENDED PRICE    CODE   DISC %   VAT CODE
       CUSTOMER PART ID      DWD REV      ECN   SHIP DATE
------------------------------------------------------------------------------------------------------------------------------------
          *********BACK ORDERED*********
          SEE SCHEDULED SHIP DATE SECTION
          *******************************
          *******ORDER CONFIRMATION******
          Direct all order questions to:
          Cinthia Yesitis - Customer Svc.
                 Phone: 650-598-1350 x220
                   Fax: 650-598-1359
          US Toll Free: 888-598-1350 x220
          *DO NOT PAY FROM THIS DOCUMENT*
          *******************************
          Zeneca Payment Schedule:
          [*] due 15 days after
          delivery of all components of
          the system.
          [*] due 15 days after
          Zeneca's acceptance of the
          system. Such acceptance shall
          not exceed forty five (45) days
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>
<TABLE>
<S>            <C>       <C>      <C>   <C>                <C>                  <C>                  <C>         <C>
SUBTOTAL                                ORDER TAX AMOUNT   ORDER TAX AMOUNT 2   ORDER TAX AMOUNT 3   ORDER VAT   ORDER TOTAL

------------------------------------------------------------------------------------------------------------------------------------
ORDER TAKER   SALESMAN   REGION
    CY          SV        AMR     3                  Customer                                                 CONTINUED NEXT PAGE
--------------------------------------
</TABLE>

[*] Confidential Treatment Requested

<PAGE>   28
[ARGONAUT      887 INDUSTRIAL ROAD, SUITE G
TECHNOLOGIES   SAN CARLOS, CA 94070
LOGO]          (650) 598-1350
               FAX (650) 598-1359

<TABLE>
<S>                 <C>               <C>    <C>       <C>               <C>                 <C>
                                      ----------------------------------------------------------------------------------------------
                                      SALES ORDER      SALES ORDER ID   ORDER DATE           ORDER TYPE
                                                       004737           09/29/98             NORMAL
                                      ----------------------------------------------------------------------------------------------
                                      PAGE   CHG NO.   CHANGE DATE      CHANGE DESCRIPTION   CONFIRMED TO
                                      3         1      10/19/98                              HEATHER CORCORAN
                                      ----------------------------------------------------------------------------------------------
                                      CURRENCY         TERMS                                 REFERENCE
                                      USD              NET 15 DAYS
-----------------------------------   ----------------------------------------------------------------------------------------------
CUSTOMER P.O. NO.   ATTENTION         SHIP VIA                          FOB                  FREIGHT TERMS
35047660            MIKE KLIMAS       BEST WAY                          DESTINATION          NO CHARGE
-----------------------------------   ----------------------------------------------------------------------------------------------
SOLD TO PHONE NO.   SOLD TO FAX NO.   RESALE NO.                                                              TAX CODE
302-886-2857        302-886-2909      DE HAS NO STATE TAX                                    T = TAXABLE  R = RESALE  N = NONTAXABLE
-----------------------------------   ----------------------------------------------------------------------------------------------
</TABLE>

<TABLE>
<S>   <C>                      <C>   <C>                        <C>   <C>
S     ZENEC002                 S     ZENEC002                   B     ZENEC$02
O     ZENECA PHARMACEUTICALS   H     ZENECA PHARMACEUTICALS     I     ZENECA PHARMACEUTICALS
L     FAIRFAX RESEARCH CENTER  I     FAIRFAX RESEARCH CENTER    L     ATTN: ACCOUNTS PAYABLE FOC 2C
D     1800 CONCORD PIKE        P     1800 CONCORD PIKE          L     PO BOX 15437
      WILMINGTON DE 19803            WILMINGTON, DE                   WILMINGTON, DE
T     USA                      T     USA 19803                  T     USA 19850-5437
O                              O                                O
</TABLE>

<TABLE>
<S>    <C>                                      <C>         <C>              <C>   <C>              <C>     <C>      <C>
------------------------------------------------------------------------------------------------------------------------------------
LINE                 DESCRIPTION                 REQUEST/   ORDER QUANTITY   U/M     UNIT PRICE     PRICE       TAX CODE
       PART ID                                  SCHEDULED     BALANCE DUE          EXTENDED PRICE    CODE   DISC %   VAT CODE
       CUSTOMER PART ID      DWD REV      ECN   SHIP DATE
------------------------------------------------------------------------------------------------------------------------------------
          after successful completion of
          installation.
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>
<TABLE>
<S>            <C>       <C>      <C>   <C>                <C>                  <C>                  <C>         <C>
SUBTOTAL                                ORDER TAX AMOUNT   ORDER TAX AMOUNT 2   ORDER TAX AMOUNT 3   ORDER VAT   ORDER TOTAL
   [*]     0                                                                                                             [*]
------------------------------------------------------------------------------------------------------------------------------------
ORDER TAKER   SALESMAN   REGION
    CY          SV        AMR     3                  Customer
--------------------------------------
</TABLE>

[*] Confidential Treatment Requested

<PAGE>   29
[ARGONAUT TECHNOLOGIES LOGO]

                TRIDENT(TM) AUTOMATED LIBRARY SYNTHESIZER SYSTEM

900132    TRIDENT AUTOMATED LIBRARY SYNTHESIZER
          --   Operators Manual and Installation Manual
          --   Installation and startup assistance provided by
               Argonaut service engineer.
          --   One year warranty on parts and labor.
          --   Trident Ship Kit
               (4) Trident Reaction Cassettes(TM)
               (192) Trident Reaction Vessel Assemblies
               (9) 250 ml Schott Reagent Bottles
               (4) 4 L Solvent Carriers
               (2) 15 L HDPE Waste Reservoir
               (1) Reagent Syringe
               (1) Solvent Syringe
               (1) Serial Cable

900167    GILSON 223 AUTOSAMPLER/SAMPLE COLLECTOR*: Modified to operate with
          Trident; includes valving, cabling, hardware interface, co-axial
          needle and autosampler and sample collector trays.

900135    TRIDENT VOLTAGE KIT

900091    TRIDENT COMPUTER SYSTEM (GATEWAY): 333 MHz Celeron CPU with 64 Mbytes
          RAM, 3.2 Gbyte hard drive, 13x CDROM, microfloppy disk, 15" svga
          monitor, mouse/keyboard, Windows NT 4.0 and Microsoft Office Pro 97
          supplied with Trident Control Software. Provided with 3 year Gateway
          warranty (1st year on-site; 2nd-3rd years return to Gateway)

SUBSTITUTE OPTIONS:

*900136   GILSON 215 AUTOSAMPLER/SAMPLE COLLECTOR: Modified to operate with
          Trident; includes valving, cabling hardware interface, co-axial needle
          and autosampler and sample collector trays. Substitute 900136 for
          900167.

*900133   TRIDENT COMPUTER SYSTEM (HP). (Substitute for 900091.): 333 MHz
          Pentium II CPU with 64 Mbytes RAM, 6.4 Gbyte hard drive, 32x CDROM,
          microfloppy disk, 17" svga monitor, mouse/keyboard, Windows NT 4.0 and
          Microsoft Office Pro 97 supplied with Trident Control Software.
          Provided with 3 year HP warranty (1st year on-site, 2nd-3rd years
          return to HP).

SPARE PARTS AND ACCESSORIES:

900168    TRIDENT REACTION CASSETTE WITH 48 REACTION VESSEL ASSEMBLIES
900165    TRIDENT EXTERNAL AGITATION-THERMAL UNIT

                       [ARGONAUT TECHNOLOGIES LETTERHEAD]

<PAGE>   30
                                FIRST AMENDMENT

This is the First Amendment to the Purchase and License Agreement between
Argonaut Technologies, Inc., and Zeneca Inc., with an Effective Date of October
30th, 1998. ("the Agreement") relating to the purchase of Trident Automation
Library System products. If any inconsistency exists between the terms of the
Agreement and the terms of this Amendment, then the terms of this Amendment
shall control. The following modifications shall be made to the Agreement.

Article 3

Article 3.2 is hereby amended to read as follows:

        3.2(b) Installation shall be started at the Installation Location no
later than February 15, 1998.

All other terms and conditions of the Agreement shall remain unchanged.

Agreed to:

Zeneca Inc.                               Argonaut Technologies Inc.

By: /s/ A.K. Willard                      By: /s/ Lissa A. Goldstein
    -------------------------------          -------------------------------

Date: 4 Jan. 99                           Date: 12/6/98
     ------------------------------          -------------------------------
<PAGE>   31
                                SECOND AMENDMENT

This is the Second Amendment to the Purchase and License Agreement between
Argonaut Technologies, Inc., and Zeneca Inc., with an Effective Date of October
30th, 1998, ("the Agreement") relating to the purchase of Trident Automation
Library System products. If any inconsistency exists between the terms of the
Agreement and the terms of this Amendment, then the terms of this Amendment
shall control. The following modifications shall be made to the Agreement.

Article 3

Article 3.2 is hereby amended to read as follows:

        3.2 (b) Installation shall be started at the Installation Location no
                later than April 30, 1999.

Article 5.1

Article 5.1 is hereby amended to read as follows:

        5.1 General. Vendor warrants that the System will conform to the
                     Specifications set forth in Exhibit C upon the completion
                     of installation and for twelve (12) months thereafter ("the
                     initial Warranty Period").

All other terms and conditions of the Agreement shall remain unchanged.

Agreed to:
Zeneca Inc.                              Argonaut Technologies, Inc.

By: /s/ A.K. Willard                     By: /s/ Lissa A. Goldenstein
       -------------------------------          -------------------------------
Date:  30 March 99                       Date: 3/24/97
      --------------------------------         --------------------------------

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00010-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00010-of-00352.parquet"}]]