Document:

2002 Stock Plan

 EXHIBIT 4.10 
  
 CORAUTUS GENETICS INC. 2002 STOCK PLAN 
  
 FIRST AMENDMENT 
 TO THE 
 GENSTAR THERAPEUTICS CORPORTION 2002 STOCK PLAN 
  
 This FIRST AMENDMENT to the GENSTAR THERAPEUTICS CORPORATION 2002 STOCK PLAN (renamed herein as the “Corautus Genetics
Inc. 2002 Stock Plan”) (the “Plan”), made and entered into by Corautus Genetics Inc., a Delaware corporation (formerly known as “GenStar Therapeutics Corporation”; the “Company”), as of April 11, 2003; 

 
 W I T N E S S E T H: 
  
 WHEREAS, the Company maintains the Plan, which is administered by a
Committee appointed by the Board of Directors of the Company (the “Board”), to provide for grants of incentive compensation to its employees, directors, and consultants; and 
  
 WHEREAS, the Company changed its name from “GenStar Therapeutics Corporation” to “Corautus Genetics
Inc.”; and 
  
 WHEREAS, accordingly, the Company
wishes to reflect its name change in the Plan document; 
  
 NOW, THEREFORE, the Company hereby amends the Plan as follows, effective as of April 11, 2003: 
  
 1. The title of the Plan as it appears at the beginning of the Plan text is changed to “CORAUTUS GENETICS INC. 2002 STOCK PLAN”. 
  
 2. The introductory clause of Section 1 of the Plan is amended to read as
follows: 
  
 “Purposes of the Plan. The purposes of
the Plan are:” 
  
 3. Section 1(h) of the Plan is amended to
read as follows: 
  
 “(h) ‘Company’ means
Corautus Genetics Inc, a Delaware corporation.” 
  
 4.
Section 1(z) of the Plan is amended to read as follows: 
  
 “(z) ‘Plan’ means the Corautus Genetics Inc. 2002 Stock Plan as contained in this plan document and as amended from time to time as provided herein.” 
  
 As Authorized by the Board of Directors on April 11, 2003

  

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 GENSTAR THERAPEUTICS CORPORATION 
  
 2002 STOCK PLAN 
  
 [NOTE: Since adoption, shares under the Plan have been adjusted for a 1-for-7 reverse stock split that was effective March 10, 2003.] 
  
 1. Purposes of the Plan. The purposes of this 2002 Stock Plan are:

  

	 	•	 	to attract and retain the best available personnel for positions of substantial responsibility, 

  

	 	•	 	to provide additional incentive to Employees, Directors and Consultants, and 

  

	 	•	 	to promote the success of the Company’s business. 

  
 Options granted under the Plan may be Incentive Stock Options or Nonstatutory Stock Options, as determined by the Administrator at the time of grant.
Stock Purchase Rights may also be granted under the Plan. 
  
 2.
Definitions. As used herein, the following definitions shall apply: 
  
 (a) “Administrator” means the Board or any of its Committees as shall be administering the Plan, in accordance with Section 4 of the Plan. 
  
 (b) “Applicable Laws” means the requirements relating to the administration of stock option plans under
U.S. state corporate laws, U.S. federal and state securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and the applicable laws of any foreign country or jurisdiction where Options or Stock
Purchase Rights are, or will be, granted under the Plan. 
  
 (c)
“Board” means the Board of Directors of the Company. 
  
 (d) “Change in Control” means the occurrence of any of the following events: 
  
 (i) Any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the “beneficial owner” (as defined in
Rule 13d-3 of the Exchange Act), directly or indirectly, of securities of the Company representing fifty percent (50%) or more of the total voting power represented by the Company’s then outstanding voting securities; or 
  
 (ii) The consummation of the sale or disposition by the Company of all or
substantially all of the Company’s assets; 
  
 (iii) A
change in the composition of the Board occurring within a two-year period, as a result of which fewer than a majority of the directors are Incumbent Directors. “Incumbent Directors” means directors who either (A) are Directors as of the
effective date of the Plan, or (B) are elected, or nominated for election, to the Board with the affirmative votes of 

  

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at least a majority of the Incumbent Directors at the time of such election or nomination (but will not include an individual whose election or nomination is
in connection with an actual or threatened proxy contest relating to the election of directors to the Company); or 
  
 (iv) The consummation of a merger or consolidation of the Company with any other corporation, other than a merger or consolidation which would result in
the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or its parent) at least fifty percent (50%) of
the total voting power represented by the voting securities of the Company or such surviving entity or its parent outstanding immediately after such merger or consolidation. 
  
 (e) “Code” means the Internal Revenue Code of 1986, as amended. 
  
 (f) “Committee” means a committee of Directors appointed by
the Board in accordance with Section 4 of the Plan. 
  
 (g)
“Common Stock” means the common stock of the Company. 
  
 (h) “Company” means GenStar Therapeutics Corporation, a Delaware corporation. 
  
 (i) “Consultant” means any natural person, including an advisor, engaged by the Company or a Parent or Subsidiary to render services to
such entity. 
  
 (j) “Director” means a member of
the Board. 
  
 (k) “Disability” means total and
permanent disability as defined in Section 22(e)(3) of the Code. 
  
 (l) “Employee” means any person, including Officers and Directors, employed by the Company or any Parent or Subsidiary of the Company. A Service Provider shall not cease to be an Employee in the case of (i) any leave of
absence approved by the Company or (ii) transfers between locations of the Company or between the Company, its Parent, any Subsidiary, or any successor. For purposes of Incentive Stock Options, no such leave may exceed ninety days, unless
reemployment upon expiration of such leave is guaranteed by statute or contract. If reemployment upon expiration of a leave of absence approved by the Company is not so guaranteed, then three (3) months following the 91st day of such leave any Incentive Stock Option held by the Optionee shall cease to be treated as an Incentive Stock Option and
shall be treated for tax purposes as a Nonstatutory Stock Option. Neither service as a Director nor payment of a director’s fee by the Company shall be sufficient to constitute “employment” by the Company. 
  
 (m) “Exchange Act” means the Securities Exchange Act of
1934, as amended. 
  
 (n) “Fair Market Value”
means, as of any date, the value of Common Stock determined as follows: 
  

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 (i) If the Common Stock is listed on any established stock exchange or a national market system,
including without limitation the Nasdaq National Market or The Nasdaq SmallCap Market of The Nasdaq Stock Market, its Fair Market Value shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such
exchange or system on the day of determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; 
  
 (ii) If the Common Stock is regularly quoted by a recognized securities dealer but selling prices are not reported, the Fair Market Value of a Share of
Common Stock shall be the mean between the high bid and low asked prices for the Common Stock on the day of determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; or 
  
 (iii) In the absence of an established market for the Common Stock, the Fair
Market Value shall be determined in good faith by the Administrator. 
  
 (o) “Incentive Stock Option” means an Option intended to qualify as an incentive stock option within the meaning of Section 422 of the Code and the regulations promulgated thereunder. 
  
 (p) “Nonstatutory Stock Option” means an Option not intended
to qualify as an Incentive Stock Option. 
  
 (q) “Notice
of Grant” means a written or electronic notice evidencing certain terms and conditions of an individual Option or Stock Purchase Right grant. The Notice of Grant is part of the Option Agreement. 
  
 (r) “Officer” means a person who is an officer of the
Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder. 
  
 (s) “Option” means a stock option granted pursuant to the Plan. 
  
 (t) “Option Agreement” means an agreement between the Company and an Optionee evidencing the terms and
conditions of an individual Option grant. The Option Agreement is subject to the terms and conditions of the Plan. 
  
 (u) “Option Exchange Program” means a program whereby outstanding Options are surrendered in exchange for Options with a lower exercise
price. 
  
 (v) “Optioned Stock” means the Common
Stock subject to an Option or Stock Purchase Right. 
  
 (w)
“Optionee” means the holder of an outstanding Option or Stock Purchase Right granted under the Plan. 
  
 (x) “Outside Director” means a Director who is not an Employee. 
  

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 (y) “Parent” means a “parent corporation,” whether now or hereafter existing,
as defined in Section 424(e) of the Code. 
  
 (z)
“Plan” means this 2002 Stock Plan. 
  
 (aa)
“Restricted Stock” means shares of Common Stock acquired pursuant to a grant of Stock Purchase Rights under Section 11 of the Plan. 
  
 (bb) “Restricted Stock Purchase Agreement” means a written agreement between the Company and the Optionee evidencing the terms and
restrictions applying to stock purchased under a Stock Purchase Right. The Restricted Stock Purchase Agreement is subject to the terms and conditions of the Plan and the Notice of Grant. 
  
 (cc) “Rule 16b-3” means Rule 16b-3 of the Exchange Act or any successor to Rule 16b-3, as in effect when
discretion is being exercised with respect to the Plan. 
  
 (dd)
“Section 16(b) “ means Section 16(b) of the Exchange Act. 
  
 (ee) “Service Provider” means an Employee, Director or Consultant. 
  
 (ff) “Share” means a share of the Common Stock, as adjusted in accordance with Section 12 of the Plan. 
  
 (gg) “Stock Purchase Right” means the right to purchase
Common Stock pursuant to Section 11 of the Plan, as evidenced by a Notice of Grant. 
  
 (hh) “Subsidiary” means a “subsidiary corporation”, whether now or hereafter existing, as defined in Section 424(f) of the Code. 
  
 3. Stock Subject to the Plan. Subject to the provisions of Section 12 of the Plan, the maximum aggregate number of
Shares that may be optioned and sold under the Plan is 10,000,000 Shares plus (a) any Shares which have been reserved but not issued under the Company’s Urogen Corp. 1999 Stock Plan (the “1999 Plan”), the Company’s Urogen Corp.
1995 Stock Plan (the “1995 Plan”) and the Company’s Urogen Corp. 1995 Director Option Plan (the “1995 Director Plan”) as of the date of stockholder approval of this Plan, (b) any Shares returned to the 1999 Plan, the 1995
Plan and the 1995 Director Plan as a result of termination of options or repurchase of Shares issued under the 1999 Plan, the 1995 Plan and the 1995 Director Plan, and (c) an annual increase to be added on the first day of the Company’s fiscal
year beginning in 2004, equal to the lesser of (i) 500,000 shares, (ii) 2% of the outstanding shares on such date or (iii) a lesser amount determined by the Board. The Shares may be authorized, but unissued, or reacquired Common Stock. 

 
 If an Option or Stock Purchase Right expires or becomes unexercisable
without having been exercised in full, or is surrendered pursuant to an Option Exchange Program, the unpurchased Shares which were subject thereto shall become available for future grant or sale under the Plan (unless the Plan has terminated);
provided, however, that Shares that have actually been issued under the Plan, whether upon exercise of an Option or Right, shall not be returned to the Plan and shall not become available for future distribution under the Plan, except 

  

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that if Shares of Restricted Stock are repurchased by the Company at their original purchase price, such Shares shall become available for future grant under
the Plan. 
  
 4. Administration of the Plan. 
  
 (a) Procedure. 
  
 (i) Multiple Administrative Bodies. Different Committees with respect
to different groups of Service Providers may administer the Plan. 
  
 (ii) Section 162(m). To the extent that the Administrator determines it to be desirable to qualify Options granted hereunder as “performance-based compensation” within the meaning of Section 162(m) of the Code, the Plan
shall be administered by a Committee of two or more “outside directors” within the meaning of Section 162(m) of the Code. 
  
 (iii) Rule 16b-3. To the extent desirable to qualify transactions hereunder as exempt under Rule 16b-3, the transactions contemplated hereunder
shall be structured to satisfy the requirements for exemption under Rule 16b-3. 
  
 (iv) Other Administration. Other than as provided above, the Plan shall be administered by (A) the Board or (B) a Committee, which committee shall be constituted to satisfy Applicable Laws. 
  
 (b) Powers of the Administrator. Subject to the provisions of the
Plan, and in the case of a Committee, subject to the specific duties delegated by the Board to such Committee, the Administrator shall have the authority, in its discretion: 
  
 (i) to determine the Fair Market Value; 
  
 (ii) to select the Service Providers to whom Options and Stock Purchase Rights may be granted hereunder; 
  
 (iii) to determine the number of shares of Common Stock to be covered by
each Option and Stock Purchase Right granted hereunder; 
  
 (iv)
to approve forms of agreement for use under the Plan; 
  
 (v) to
determine the terms and conditions, not inconsistent with the terms of the Plan, of any Option or Stock Purchase Right granted hereunder. Such terms and conditions include, but are not limited to, the exercise price, the time or times when Options
or Stock Purchase Rights may be exercised (which may be based on performance criteria), any vesting acceleration or waiver of forfeiture restrictions, and any restriction or limitation regarding any Option or Stock Purchase Right or the shares of
Common Stock relating thereto, based in each case on such factors as the Administrator, in its sole discretion, shall determine; 
  
 (vi) to reduce the exercise price of any Option or Stock Purchase Right to the then current Fair Market Value if the Fair Market Value of the Common
Stock covered by 

  

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such Option or Stock Purchase Right shall have declined since the date the Option or Stock Purchase Right was granted; 
  
 (vii) to institute an Option Exchange Program; 
  
 (viii) to construe and interpret the terms of the Plan and awards granted
pursuant to the Plan; 
  
 (ix) to prescribe, amend and rescind
rules and regulations relating to the Plan, including rules and regulations relating to sub-plans established for the purpose of satisfying applicable foreign laws; 
  
 (x) to modify or amend each Option or Stock Purchase Right (subject to Section 14(c) of the Plan), including the
discretionary authority to extend the post-termination exercisability period of Options longer than is otherwise provided for in the Plan; 
  
 (xi) to allow Optionees to satisfy withholding tax obligations by electing to have the Company withhold from the Shares to be issued upon exercise of an
Option or Stock Purchase Right that number of Shares having a Fair Market Value equal to the minimum amount required to be withheld. The Fair Market Value of the Shares to be withheld shall be determined on the date that the amount of tax to be
withheld is to be determined. All elections by an Optionee to have Shares withheld for this purpose shall be made in such form and under such conditions as the Administrator may deem necessary or advisable; 
  
 (xii) to authorize any person to execute on behalf of the Company any
instrument required to effect the grant of an Option or Stock Purchase Right previously granted by the Administrator; 
  
 (xiii) to make all other determinations deemed necessary or advisable for administering the Plan. 
  
 (c) Effect of Administrator’s Decision. The Administrator’s
decisions, determinations and interpretations shall be final and binding on all Optionees and any other holders of Options or Stock Purchase Rights. 
  
 5. Eligibility. Nonstatutory Stock Options and Stock Purchase Rights may be granted to Service Providers. Incentive Stock Options may be granted
only to Employees. 
  
 6. Limitations. 
  
 (a) Each Option shall be designated in the Option Agreement as either an
Incentive Stock Option or a Nonstatutory Stock Option. However, notwithstanding such designation, to the extent that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock Options are exercisable for the first time by
the Optionee during any calendar year (under all plans of the Company and any Parent or Subsidiary) exceeds $100,000, such Options shall be treated as Nonstatutory Stock Options. For purposes of this Section 6(a), Incentive Stock Options shall be
taken into account in the order in which they were granted. The 

  

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Fair Market Value of the Shares shall be determined as of the time the Option with respect to such Shares is granted. 
  
 (b) Neither the Plan nor any Option or Stock Purchase Right shall confer upon
an Optionee any right with respect to continuing the Optionee’s relationship as a Service Provider with the Company, nor shall they interfere in any way with the Optionee’s right or the Company’s right to terminate such relationship
at any time, with or without cause. 
  
 (c) The following
limitations shall apply to grants of Options: 
  
 (i) No Service
Provider shall be granted, in any fiscal year of the Company, Options to purchase more than 750,000 Shares. 
  
 (ii) In connection with his or her initial service, a Service Provider may be granted Options to purchase up to an additional 2,500,000 Shares, which
shall not count against the limit set forth in subsection (i) above. 
  
 (iii) The foregoing limitations shall be adjusted proportionately in connection with any change in the Company’s capitalization as described in Section 12. 
  
 (iv) If an Option is cancelled in the same fiscal year of the Company in which it was granted (other than in connection
with a transaction described in Section 12), the cancelled Option will be counted against the limits set forth in subsections (i) and (ii) above. For this purpose, if the exercise price of an Option is reduced, the transaction will be treated as a
cancellation of the Option and the grant of a new Option. 
  
 7.
Term of Plan. Subject to Section 18 of the Plan, the Plan shall become effective upon its adoption by the Board. It shall continue in effect for a term of ten (10) years unless terminated earlier under Section 14 of the Plan. 
  
 8. Term of Option. The term of each Option shall be stated in the
Option Agreement. In the case of an Incentive Stock Option, the term shall be ten (10) years from the date of grant or such shorter term as may be provided in the Option Agreement. Moreover, in the case of an Incentive Stock Option granted to an
Optionee who, at the time the Incentive Stock Option is granted, owns stock representing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or any Parent or Subsidiary, the term of the Incentive
Stock Option shall be five (5) years from the date of grant or such shorter term as may be provided in the Option Agreement. 
  
 9. Option Exercise Price and Consideration. 
  
 (a) Exercise Price. The per share exercise price for the Shares to be issued pursuant to exercise of an Option shall be determined by the
Administrator, subject to the following: 
  
 (i) In the case of
an Incentive Stock Option 
  

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 (A) granted to an Employee who, at the time the Incentive Stock Option is granted, owns stock
representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the per Share exercise price shall be no less than 110% of the Fair Market Value per Share on the date of grant.

  
 (B) granted to any Employee other than an Employee described
in paragraph (A) immediately above, the per Share exercise price shall be no less than 100% of the Fair Market Value per Share on the date of grant. 
  
 (ii) In the case of a Nonstatutory Stock Option, the per Share exercise price shall be determined by the Administrator. In the case of a Nonstatutory
Stock Option intended to qualify as “performance-based compensation” within the meaning of Section 162(m) of the Code, the per Share exercise price shall be no less than 100% of the Fair Market Value per Share on the date of grant.

  
 (iii) Notwithstanding the foregoing, Options may be granted
with a per Share exercise price of less than 100% of the Fair Market Value per Share on the date of grant pursuant to a merger or other corporate transaction. 
  

(b) Waiting Period and Exercise Dates. At the time an Option is granted, the Administrator shall establish the period within which the Option
may be exercised and shall determine any conditions that must be satisfied before the Option may be exercised. Following the initial grant of an Option, the Administrator may, in its discretion, accelerate the time at which an Option (or any part
thereof) may be exercised and/or extend the post-termination exercisability period of an Option longer than otherwise provided for in the relevant Option Agreement or the Plan, provided that any such modification of the terms and conditions of an
Option shall be subject to the provisions of Section 14(c) (implemented as if it applied to modifications of an outstanding Option). 
  
 (c) Form of Consideration. The Administrator shall determine the acceptable form of consideration for exercising an Option, including the method of
payment. In the case of an Incentive Stock Option, the Administrator shall determine the acceptable form of consideration at the time of grant. Such consideration may consist entirely of: 
  
 (i) cash; 
  
 (ii) check; 
  
 (iii) promissory note; 
  
 (iv) other Shares which, in the case of Shares acquired directly or indirectly from the Company, (A) have been owned by the Optionee for more than six
(6) months on the date of surrender, and (B) have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which said Option shall be exercised; 
  
 (v) consideration received by the Company under a cashless exercise program
implemented by the Company in connection with the Plan; 
  

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 (vi) a reduction in the amount of any Company liability to the Optionee, including any liability
attributable to the Optionee’s participation in any Company-sponsored deferred compensation program or arrangement; 
  
 (vii) any combination of the foregoing methods of payment; or 
  
 (viii) such other consideration and method of payment for the issuance of Shares to the extent permitted by Applicable Laws. 
  
 10. Exercise of Option. 
  
 (a) Procedure for Exercise; Rights as a Stockholder. Any Option
granted hereunder shall be exercisable according to the terms of the Plan and at such times and under such conditions as determined by the Administrator and set forth in the Option Agreement. Unless the Administrator provides otherwise, vesting of
Options granted hereunder shall be suspended during any unpaid leave of absence. An Option may not be exercised for a fraction of a Share. 
  
 An Option shall be deemed exercised when the Company receives: (i) written or electronic notice of exercise (in accordance with the Option Agreement)
from the person entitled to exercise the Option, and (ii) full payment for the Shares with respect to which the Option is exercised. Full payment may consist of any consideration and method of payment authorized by the Administrator and permitted by
the Option Agreement and the Plan. Shares issued upon exercise of an Option shall be issued in the name of the Optionee or, if requested by the Optionee, in the name of the Optionee and his or her spouse. Until the Shares are issued (as evidenced by
the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or receive dividends or any other rights as a stockholder shall exist with respect to the Optioned Stock, notwithstanding the
exercise of the Option. The Company shall issue (or cause to be issued) such Shares promptly after the Option is exercised. No adjustment will be made for a dividend or other right for which the record date is prior to the date the Shares are
issued, except as provided in Section 12 of the Plan. 
  
 Exercising an Option in any manner shall decrease the number of Shares thereafter available, both for purposes of the Plan and for sale under the Option, by the number of Shares as to which the Option is exercised. 
  
 (b) Termination of Relationship as a Service Provider. If an Optionee
ceases to be a Service Provider, other than upon the Optionee’s death or Disability, the Optionee may exercise his or her Option within such period of time as is specified in the Option Agreement to the extent that the Option is vested on the
date of termination (but in no event later than the expiration of the term of such Option as set forth in the Option Agreement). In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for three (3) months
following the Optionee’s termination. If, on the date of termination, the Optionee is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the
Optionee does not exercise his or her Option within the time specified by the Administrator, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan. 
  

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 (c) Disability of Optionee. If an Optionee ceases to be a Service Provider as a result of the
Optionee’s Disability, the Optionee may exercise his or her Option within such period of time as is specified in the Option Agreement to the extent the Option is vested on the date of termination (but in no event later than the expiration of
the term of such Option as set forth in the Option Agreement). In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for twelve (12) months following the Optionee’s termination. If, on the date of
termination, the Optionee is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Optionee does not exercise his or her Option within the time
specified herein, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan. 
  
 (d) Death of Optionee. If an Optionee dies while a Service Provider, the Option may be exercised following the Optionee’s death within such
period of time as is specified in the Option Agreement to the extent that the Option is vested on the date of death (but in no event may the option be exercised later than the expiration of the term of such Option as set forth in the Option
Agreement), by the Optionee’s designated beneficiary, provided such beneficiary has been designated prior to Optionee’s death in a form acceptable to the Administrator. If no such beneficiary has been designated by the Optionee, then such
Option may be exercised by the personal representative of the Optionee’s estate or by the person(s) to whom the Option is transferred pursuant to the Optionee’s will or in accordance with the laws of descent and distribution. In the
absence of a specified time in the Option Agreement, the Option shall remain exercisable for twelve (12) months following Optionee’s death. If, at the time of death, Optionee is not vested as to his or her entire Option, the Shares covered by
the unvested portion of the Option shall immediately revert to the Plan. If the Option is not so exercised within the time specified herein, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan. 
  
 11. Stock Purchase Rights. 
  
 (a) Rights to Purchase. Stock Purchase Rights may be issued either
alone, in addition to, or in tandem with other awards granted under the Plan and/or cash awards made outside of the Plan. After the Administrator determines that it will offer Stock Purchase Rights under the Plan, it shall advise the offeree in
writing or electronically, by means of a Notice of Grant, of the terms, conditions and restrictions related to the offer, including the number of Shares that the offeree shall be entitled to purchase, the price to be paid, and the time within which
the offeree must accept such offer. The offer shall be accepted by execution of a Restricted Stock Purchase Agreement in the form determined by the Administrator. 
  
 (b) Repurchase Option. Unless the Administrator determines otherwise, the Restricted Stock Purchase Agreement shall
grant the Company a repurchase option exercisable upon the voluntary or involuntary termination of the purchaser’s service with the Company for any reason (including death or Disability). The purchase price for Shares repurchased pursuant to
the Restricted Stock Purchase Agreement shall be the original price paid by the purchaser and may be paid by cancellation of any indebtedness of the purchaser to the Company. The repurchase option shall lapse at a rate determined by the
Administrator. 
  

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 (c) Other Provisions. The Restricted Stock Purchase Agreement shall contain such other terms,
provisions and conditions not inconsistent with the Plan as may be determined by the Administrator in its sole discretion. 
  
 (d) Rights as a Stockholder. Once the Stock Purchase Right is exercised, the purchaser shall have the rights equivalent to those of a stockholder,
and shall be a stockholder when his or her purchase is entered upon the records of the duly authorized transfer agent of the Company. No adjustment will be made for a dividend or other right for which the record date is prior to the date the Stock
Purchase Right is exercised, except as provided in Section 12 of the Plan. 
  
 (i) Transferability of Options and Stock Purchase Rights. Unless determined otherwise by the Administrator, an Option or Stock Purchase Right may not be sold, pledged, assigned, hypothecated, transferred, or
disposed of in any manner other than by will or by the laws of descent or distribution and may be exercised, during the lifetime of the Optionee, only by the Optionee. If the Administrator makes an Option or Stock Purchase Right transferable, such
Option or Stock Purchase Right shall contain such additional terms and conditions as the Administrator deems appropriate. 
  
 12. Adjustments Upon Changes in Capitalization, Merger or Change in Control. 
  
 (a) Changes in Capitalization. Subject to any required action by the stockholders of the Company, the number of
shares of Common Stock that have been authorized for issuance under the Plan but as to which no Options or Stock Purchase Rights have yet been granted or which have been returned to the Plan upon cancellation or expiration of an Option or Stock
Purchase Right, the number of Shares that may be added annually to the Plan pursuant to Section 3(i), and the number of shares of Common Stock as well as the price per share of Common Stock covered by each such outstanding Option or Stock Purchase
Right, shall be proportionately adjusted for any increase or decrease in the number of issued shares of Common Stock resulting from a stock split, reverse stock split, stock dividend, combination or reclassification of the Common Stock, or any other
increase or decrease in the number of issued shares of Common Stock effected without receipt of consideration by the Company; provided, however, that conversion of any convertible securities of the Company shall not be deemed to have been
“effected without receipt of consideration.” Such adjustment shall be made by the Board, whose determination in that respect shall be final, binding and conclusive. Except as expressly provided herein, no issuance by the Company of shares
of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares of Common Stock subject to an Option or Stock Purchase
Right. 
  
 (b) Dissolution or Liquidation. In the event of
the proposed dissolution or liquidation of the Company, the Administrator shall notify each Optionee as soon as practicable prior to the effective date of such proposed transaction. The Administrator in its discretion may provide for an Optionee to
have the right to exercise his or her Option until ten (10) days prior to such transaction as to all of the Optioned Stock covered thereby, including Shares as to which the Option would not otherwise be exercisable. In addition, the Administrator
may provide that any Company repurchase option applicable to any Shares purchased upon exercise of an Option 

  

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or Stock Purchase Right shall lapse as to all such Shares, provided the proposed dissolution or liquidation takes place at the time and in the manner
contemplated. To the extent it has not been previously exercised, an Option or Stock Purchase Right will terminate immediately prior to the consummation of such proposed action. 
  
 (c) Merger or Change in Control. In the event of a merger of the Company with or into another corporation, or a
Change in Control, each outstanding Option and Stock Purchase Right shall be assumed or an equivalent option or right substituted by the successor corporation or a Parent or Subsidiary of the successor corporation.  
  
 In the event that the successor corporation refuses to assume or substitute
for the Option or Stock Purchase Right, the Optionee shall fully vest in and have the right to exercise the Option or Stock Purchase Right as to all of the Optioned Stock, including Shares as to which it would not otherwise be vested or exercisable.
If an Option or Stock Purchase Right becomes fully vested and exercisable in lieu of assumption or substitution in the event of a merger or sale of assets, the Administrator shall notify the Optionee in writing or electronically that the Option or
Stock Purchase Right shall be fully vested and exercisable for a period of fifteen (15) days from the date of such notice, and the Option or Stock Purchase Right shall terminate upon the expiration of such period. 
  
 For the purposes of this subsection (c), the Option or Stock Purchase Right
shall be considered assumed if, following the merger or Change in Control, the option or right confers the right to purchase or receive, for each Share of Optioned Stock subject to the Option or Stock Purchase Right immediately prior to the merger
or Change in Control, the consideration (whether stock, cash, or other securities or property) received in the merger or Change in Control by holders of Common Stock for each Share held on the effective date of the transaction (and if holders were
offered a choice of consideration, the type of consideration chosen by the holders of a majority of the outstanding Shares); provided, however, that if such consideration received in the merger or Change in Control is not solely common stock of the
successor corporation or its Parent, the Administrator may, with the consent of the successor corporation, provide for the consideration to be received upon the exercise of the Option or Stock Purchase Right, for each Share of Optioned Stock subject
to the Option or Stock Purchase Right, to be solely common stock of the successor corporation or its Parent equal in fair market value to the per share consideration received by holders of Common Stock in the merger or Change in Control. 

 
 13. Date of Grant. The date of grant of an Option or Stock Purchase
Right shall be, for all purposes, the date on which the Administrator makes the determination granting such Option or Stock Purchase Right, or such other later date as is determined by the Administrator. Notice of the determination shall be provided
to each Optionee within a reasonable time after the date of such grant. 
  
 14. Amendment and Termination of the Plan. 
  
 (a) Amendment and Termination. The Board may at any time amend, alter, suspend or terminate the Plan. 
  
 (b) Stockholder Approval. The Company shall obtain stockholder approval of any Plan amendment to the extent necessary and desirable to comply with
Applicable Laws. 
  

 13 

 (c) Effect of Amendment or Termination. No amendment, alteration, suspension or termination of the
Plan shall impair the rights of any Optionee, unless mutually agreed otherwise between the Optionee and the Administrator, which agreement must be in writing and signed by the Optionee and the Company. Termination of the Plan shall not affect the
Administrator’s ability to exercise the powers granted to it hereunder with respect to Options granted under the Plan prior to the date of such termination. 
  
 15. Conditions Upon Issuance of Shares. 
  
 (a) Legal Compliance. Shares shall not be issued pursuant to the exercise of an Option or Stock Purchase Right unless
the exercise of such Option or Stock Purchase Right and the issuance and delivery of such Shares shall comply with Applicable Laws and shall be further subject to the approval of counsel for the Company with respect to such compliance. 

 
 (b) Investment Representations. As a condition to the exercise of
an Option or Stock Purchase Right, the Company may require the person exercising such Option or Stock Purchase Right to represent and warrant at the time of any such exercise that the Shares are being purchased only for investment and without any
present intention to sell or distribute such Shares if, in the opinion of counsel for the Company, such a representation is required. 
  
 16. Inability to Obtain Authority. The inability of the Company to obtain authority from any regulatory body having jurisdiction, which authority
is deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares hereunder, shall relieve the Company of any liability in respect of the failure to issue or sell such Shares as to which such requisite authority
shall not have been obtained. 
  
 17. Reservation of
Shares. The Company, during the term of this Plan, will at all times reserve and keep available such number of Shares as shall be sufficient to satisfy the requirements of the Plan. 
  
 18. Stockholder Approval. The Plan shall be subject to approval by the stockholders of the Company within twelve (12)
months after the date the Plan is adopted. Such stockholder approval shall be obtained in the manner and to the degree required under Applicable Laws. 
  

 14Employee Stock Purchase Plan

 EXHIBIT 4.11 
  
 GENSTAR THERAPEUTICS CORPORATION 
 EMPLOYEE STOCK PURCHASE PLAN 
  
 [Note: Since adoption, the Corporation has conducted a 1-for-7 reverse stock split that was effective March 10, 2003. ] 
  
 1. Purpose. This Employee Stock Purchase Plan (the “Plan”) is intended to serve as an incentive to and to encourage stock ownership by
certain eligible employees of Genstar Therapeutics Corporation, a Delaware corporation, and certain affiliates as set forth below (the “Corporation”), so that they may acquire or increase their proprietary interest in the success of the
Corporation, and to encourage them to remain in the service of the Corporation. This Plan is intended to qualify as an employee stock purchase plan, as defined in Section 423 of the Internal Revenue Code of 1986, as amended (the “Code”).

  
 2. Administration. 
  
 2.1 Committee. The Plan shall be administered by the Board of
Directors of the Corporation (“Board of Directors”) or a committee of two or more members appointed by the Board of Directors (the “Committee”) who are Non-Employee Directors, as such term is defined in Rule 16b-3 promulgated
under Section 16 of the Securities Exchange Act of 1934, as amended, and outside directors, as defined in Treasury Regulations § 1.162-27(e)(3). The Committee shall select one of its members as Chairman and shall appoint a Secretary, who need
not be a member of the Committee. The Committee shall hold meetings at such times and places as it may determine and minutes of such meetings shall be recorded. Acts by a majority of the Committee in a meeting at which a quorum is present and acts
approved in writing by a majority of the members of the Committee shall be valid acts of the Committee. 
  
 2.2 Term. If the Board of Directors selects a Committee, the members of the Committee shall serve on the Committee for a period of time as
determined by the Board of Directors and shall be subject to removal by the Board of Directors at any time. The Board of Directors may terminate the function of the Committee at any time and resume all powers and authority previously delegated to
the Committee. 
  
 2.3 Authority. The Committee shall have
sole discretion and authority to prescribe, amend and rescind the rules and regulations relating to the Plan and to make all other determinations necessary and advisable for the administration of the Plan. 
  
 2.4 Interpretation. The interpretation and construction by the
Committee of any provisions of the Plan or of any option granted under it shall be final and binding on all parties having an interest in this Plan or any option granted hereunder. No member of the Committee shall be liable for any action or
determination made in good faith with respect to the Plan or any option granted under the plan. 
  

 1 

 2.5 Agent. The Committee may employ such legal counsel, consultants, brokers and agents as it may
deem desirable for the administration of the Plan and may rely upon any opinion received from any such counsel or consultant and any computation received from any such consultant, broker or agent. The Committee may, in its sole discretion, designate
an agent (“Agent”) to administer the Plan, keep records, send statements of account to employees and to perform other duties relating to the Plan, as the Committee may request from time to time. 
  
 3. Eligibility. 
  
 3.1 General. Except as otherwise provided in Section 3.2, all regular
employees of the Corporation, or any “parent” or “subsidiary” corporation of the Corporation, as defined in Section 424 of the Code (“Parent” or “Subsidiary”) (i) whose customary employment is at least 20
hours per week and (ii) who are employed on an Enrollment Date (as defined below) are eligible to participate (“Eligible Employee”). All Eligible Employees who elect to participate in this Plan shall have the same rights and privileges
except as provided in Section 3.5. Notwithstanding the above, employees of a Parent or Subsidiary shall only be Eligible Employees if the Committee designates such corporation as a participant. For purposes of this Plan, the term
“Corporation” shall also include any Parent or Subsidiary, if applicable. 
  
 3.2 Excluded Eligible Employees. Notwithstanding any other provision in this Agreement, no employee can be granted the right to purchase stock under this Plan if such employee (i) is customarily not employed by
the Corporation for more than five months a year, or (ii) immediately after the right to purchase such stock is granted, owns stock possessing 5% or more of the total combined voting power or value of all classes of the Corporation’s stock (or
of the Corporation’s Parent or Subsidiary.) For purposes of determining stock ownership, the rules of Section 424(d) of the Code shall apply, and stock which the employee may purchase under outstanding options, including rights to purchase
stock under this Plan, shall be treated as stock owned by the employee. 
  
 3.3 Semi-Annual Offerings. Until the Plan is terminated, the Plan will be implemented by semi-annual offerings of the right to purchase the Corporation’s common stock pursuant to this Plan (the “Offerings”) beginning
on the 1st day of May and the 1st day of November in each year and terminating on April 30 of the second year thereafter (24 months) for the Offering beginning May 1 and on October 31 of the
second year thereafter (24 months) for the Offering beginning November 1 of such year (“Offering Period”); provided, however, that each semi-annual Offering may, in the discretion of the Committee exercised prior to the commencement
thereof, be changed to semi-annual or annual Offerings with a shorter duration. Each May 1st and November 1st in an Offering Period shall be an “Enrollment Date.” As used in the Plan, “Entry Date” means the May 1 or November 1,
as the case may be, on which the particular Offering Period begins and “Termination Date” means the April 30 or October 31, as the case may be, on which the particular Offering Period terminates. 
  
 3.4 Participation. 
  
 3.4.1 Eligible Employees who wish to participate in the Plan shall execute
a form (“Enrollment Form”) to be furnished by the Corporation, indicating that they authorize and instruct the Corporation to deduct from their semi-monthly pay a specified 

  

 2 

 
percentage of their respective Base Compensation (as defined below), to be applied to the purchase of stock pursuant to this Plan for each individual’s
account. Enrollment Forms will be effective as of the next Enrollment Date. All payroll deductions made for a participant shall be credited to his account under the Plan. A participant may not make any separate cash payment into such account.
Subject to Section 3.5, each participant may designate any whole percentage of his or her base salary or any fixed dollar amount per pay period to be contributed to the Plan on his or her behalf; provided that any fixed dollar amount shall not
exceed 15% of such Eligible Employee’s Base Compensation for such Offer. Upon the participant’s written request to the Corporation, the amount of the payroll deduction will be changed as of the next Enrollment Date (as defined above)
following such request. Any election by a member to decrease his or her payroll deductions to 0% shall be deemed to be an election to withdraw from the Plan effective immediately following the purchase of shares on the next Termination Date.
Nonparticipating employees who are eligible or become eligible may execute payroll deduction authorizations and become participants in the Plan as of the Enrollment Date after which they first satisfy the eligibility requirements set forth in
Section 3.1. The election by the participant must be received prior to the Enrollment Date. Payroll deductions will commence with pay checks issued not later than the next pay period after the Enrollment Date following receipt of the executed
Enrollment Form. 
  
 3.4.2 Re-Enrollment Upon Expiration of
Offering Period. At the end of a participant’s then-current Offering Period, the participant automatically shall be enrolled in the next succeeding Offering Period (a “Re-enrollment”) unless, in a manner and at a time specified by the
Corporation, but in no event later than the day before the first day of such succeeding Offering Period, the participant notifies the Corporation in writing of the participant’s desire not to be so enrolled. Re-enrollment shall be at the same
percentage of contributions as the participant’s prior participation unless the participant by timely written notice changes the percentage of contribution. No participant shall be automatically re-enrolled whose participation terminates by
operation of Section 3.11 or who, during the preceding Offering Period, has reduced his or her percentage of contribution to 0% or has notified the Corporation in writing of the participant’s withdrawal from participation in the Plan.

  
 3.5 Limitation on Participation. An Eligible Employee
may not elect to contribute to the Plan more than the lesser of $25,000 or 15% of such Eligible Employee’s Base Compensation (as defined below) for the calendar year. “Base Compensation” means the base compensation paid in cash to a
participant by the Corporation, including salaries and wages, but excluding bonuses, incentive compensation, commissions, overtime pay, moving or relocation allowances, car allowances, imputed income attributable to cars, taxable fringe benefits and
similar items. In addition, a participant may not elect to make such contributions to the Plan which would permit stock with a fair market value exceeding $25,000 to be purchased for his or her account in any calendar year under all stock purchase
plans of the Corporation as determined under Section 423 of the Code. For this purpose, the fair market value of the stock will be determined at the time that the participant is granted the right to purchase Stock. All share amounts set forth herein
are subject to adjustment as provided in Section 5. 
  
 3.6
Purchase of Stock. Unless a participant gives written notice to the Corporation as hereinafter provided, a participant’s option to acquire stock with payroll deductions made during any Offering Period will be deemed to have been
exercised 

  

 3 

 
automatically on the Termination Date applicable to such Offering for the purchase of the number of full shares of stock which the accumulated payroll
deductions in his account at that time will purchase at the applicable option price (but not in excess of the number of shares, for which options have been granted to the employee pursuant to Section 4.1), and any excess in the participant’s
account at that time will be returned to the participant. Any unexercised options on any Termination Date shall terminate and be null and void. 
  
 3.7 Delivery of Stock. As promptly as practicable after the Termination Date of each Offering, the Corporation will deliver to each participant, as
appropriate, the stock purchased upon exercise of an option. 
  
 3.8 Discontinuing Payroll Deductions. If a participant wishes to discontinue employee contributions entirely, he or she may do so by filing a new enrollment form at any time. Payroll withholding shall cease as soon as reasonably
practicable after such form has been received by the Corporation. Discontinuation of payroll deductions shall be treated as an election to withdraw from the Plan and amounts standing to the Participant’s credit prior to his or her election to
discontinue contributions shall be distributed to him or her in accordance with Section 3.9. 
  
 3.9 Withdrawal or Termination. A participant may elect to withdraw from the Plan by filing the prescribed form with the Corporation at any time. If the participant withdraws from the Plan, the participant will
be returned all accumulated payroll deductions, without interest. A participant who discontinues contributions to the Plan under Section 3.8, or withdraws from the Plan under this Section may again become a participant, if he or she is then an
Eligible Employee, by following the procedure described in Section 3.4. 
  
 3.10 Payment of Interest. No interest will be paid or allowed on any money paid into the Plan or credited to the account of any participant. 
  
 3.11 Termination. In the event of a participant’s death or termination of employment, the discontinuance of the Plan by the Corporation, the
election of the employee to withdraw from the Plan for any reason, or in the event the employee is no longer an Eligible Employee, all of such participant’s accumulated payroll deductions contributed to the Plan during the Offering Period in
which such withdrawal or termination occurs will be distributed, without interest, to his or her name or order, or in the event of death, to the name of his or her legal representative, as promptly as practicable. 
  
 3.12 Limitation on Subscriptions. The total number of shares of stock
available for purchase under the Plan is 1,000,000 shares, subject to adjustment as set forth in Section 5. In the event that the aggregate number of shares that all participants elect to purchase on a Termination Date exceeds the maximum number of
shares remaining available for issuance under this Section, then the number of shares to which each participant is entitled shall be determined by multiplying the number of shares available for issuance by a fraction, the numerator of which is the
number of shares that such participant has elected to purchase and the denominator of which is the number of shares that all participants have elected to purchase. 
  

 4 

 3.13 Expenses. All costs of maintaining records and executing transfers will be borne by the
Corporation. 
  
 3.14 Fair Market Value. The fair market
value of a share of stock on any relevant date shall be determined in accordance with the following provisions: 
  
 3.14.1 If the stock at the time is neither listed nor admitted to trading on any stock exchange nor traded in the over-the-counter market, then the fair
market value shall be the value of the stock as determined by the Board of Directors in their last valuation of the Stock, after taking into account such factors as the Board of Directors shall deem appropriate. 
  
 3.14.2 If the stock is not at the time listed or admitted to trading on any
stock exchange but is traded in the over-the-counter market, the fair market value shall be the mean between the highest bid and lowest asked prices (or, if such information is available, the closing selling price) of one share of stock on the date
in question in the over-the-counter market, as such prices are reported by the National Association of Securities Dealers through its NASDAQ system or any successor system. If there are no reported bid and asked prices (or closing selling price) for
the stock on the date in question, then the mean between the highest bid price and lowest asked price (or the closing selling price) on the last preceding date for which such quotations exist shall be determinative of fair market value. 

 
 3.14.3 If the stock is at the time listed or admitted to trading on any
stock exchange, then the fair market value shall be the closing selling price of one share of stock on the date in question on the stock exchange determined by the Committee to be the primary market for the stock, as such price is officially quoted
in the composite tape of transactions on such exchange. If there is no reported sale of stock on such exchange on the date in question, then the fair market value shall be the closing selling price on the exchange on the last preceding date for
which such quotation exists. 
  
 4. Granting of Options.

  
 4.1 Number of Option Shares. Subject to Section 3.5,
on the Entry Date of each Offering, a participating employee shall be deemed to have been granted an option to purchase a maximum number of shares of the stock of the Corporation equal to $75,000 divided by the fair market value of a share
determined at the grant date of such purchase right. The market value of the Corporation’s stock shall be determined as provided in Section 3.14. 
  
 4.2 Option Price. The option price of stock purchased with payroll deductions made during an Offering for a participant therein shall be the lower
of (i) 85% of the fair market value of the stock of the Corporation on the Entry Date or (ii) 85% of the fair market value on the date of purchase as set forth in Section 3.6. 
  
 5. Adjustments upon Changes in Capitalization. 
  
 5.1 Subdivision or Consolidation. Subject to any required action by shareholders of the Corporation, the number of
shares of stock covered by each outstanding option, and the exercise price thereof, shall be proportionately adjusted for any increase or decrease in the number of issued shares of stock of the Corporation resulting from a subdivision 

  

 5 

 
or consolidation of shares or the payment of a stock dividend (but only on the stock) or any other increase or decrease in the number of such shares effected
without receipt of consideration by the Corporation including, but not limited to, a stock split, reverse stock split, recapitalization, combination or reclassification. Any fraction of a share subject to an option that would otherwise result from
an adjustment pursuant to this Section shall be rounded downward to the next full number of shares without other compensation or consideration to the holder of such option. 
  
 5.2 Capital Transactions. Upon a sale or exchange of all or substantially all of the assets of the Corporation, a
merger or consolidation in which the Corporation is not the surviving corporation, a merger, reorganization or consolidation in which the Corporation is the surviving corporation and shareholders of the Corporation exchange their stock for
securities or property, a liquidation of the Corporation or similar transaction (“Capital Transaction”), this Plan and each option to purchase stock issued under this Plan shall terminate, unless such options are assumed by a successor
corporation in the Capital Transaction, on the date of such Capital Transaction; provided, however, that unless the outstanding options are assumed by a successor corporation in the Capital Transaction, then the day prior to the date of the Capital
Transaction shall be a Termination Date and the funds held in each participant’s account shall be used to purchase the number of full shares of stock at the applicable option price (but not in excess of the number of shares for which options
have been granted to the participant pursuant to Section 4.1) and any excess in the participant’s account at that time will be returned to the participant. 
  

5.3 Adjustments. To the extent that the foregoing adjustments relate to stock or securities of the Corporation, such adjustments shall be made
by the Committee, whose determination in that respect shall be final, binding and conclusive. 
  
 5.4 Ability to Adjust. The grant of an option pursuant to the Plan shall not affect in any way the right or power of the Corporation to make adjustments, reclassifications, reorganizations or changes of its
capital or business structure or to merge, consolidate, dissolve, liquidate, sell or transfer all or any part of its business or assets. 
  
 5.5 Notice of Adjustment. Whenever the Corporation shall take any action resulting in any adjustment provided for in this Section, the Corporation
shall forthwith deliver notice of such action to each participant, which notice shall set forth the number of shares subject to the option and the exercise price thereof resulting from such adjustment. 
  
 5.6 Limitation on Adjustments. Any adjustment, assumption or
substitution shall not provide any participant with any additional benefit under his or her option and shall comply with Section 425 of the Code, if applicable. 
  

6. Transferability. Options granted under this Plan may not be sold, pledged, assigned or transferred in any manner other than by will or by the
laws of descent and distribution, and may be exercised during the lifetime of a participant only by such participant. Any transfer in violation of this provision shall void such option. No option shall be pledged or hypothecated in any way, nor
shall any option be subject to execution, attachment or similar process. 
  

 6 

 7. Rights as a Shareholder. A participant shall have no rights as a shareholder with respect to
any stock underlying any option until the date of the issuance to such participant a certificate for such shares. No adjustment shall be made for dividends (ordinary or extraordinary, whether in cash, securities or other property) or distributions
or other rights for which the record date is prior to the date such stock certificate is issued, except as provided in Section 6. 
  
 8. No Right of Employment. Neither the grant nor exercise of any option nor anything in this Plan shall impose upon the Corporation or any other
corporation any obligation to employ or continue to employ any participant. The right of the Corporation and any other corporation to terminate any employee shall not be diminished or affected because an option has been granted to such employee.

  
 9. Amendment or Termination of the Plan. The Board of
Directors of the Corporation may, subject to any requested shareholder approval, amend, suspend, discontinue or terminate the Plan, or revise or amend it in any respect whatsoever. The Board of Directors of the Corporation shall be entitled to
terminate the Plan at anytime in their sole discretion. Upon termination of the Plan, all accumulated payroll deductions contributed to the Plan during the Offering Period in which such termination occurs will be distributed without interest to
participants and participants’ options to purchase stock under this Plan will be canceled, as of the date of the Plan termination. 
  
 10. Term of Plan. This Plan is effective on the date the Plan is adopted by the Board of Directors and options may be granted pursuant to the Plan
from time to time until March 31, 2011. 
  
 11. Approval of
Board of Directors and Shareholders. The Plan shall not take effect until approved by the Board of Directors of the Corporation. This Plan shall be approved by a vote of the shareholders by April 11, 2002. In the event such shareholder vote is
not obtained, all options granted hereunder, whether vested or unvested, shall be rescinded and shall be null and void. 
  
 12. Application of Funds. The proceeds received by the Corporation from the sale of stock pursuant to options may be used for general corporate
purposes. 
  
 13. Reservation of Shares. The Corporation,
during the term of this Plan, shall at all times reserve and keep available such number of shares of stock as shall be sufficient to satisfy the requirements of the Plan. 
  
 14. No Obligation to Exercise Option. The granting of an option shall not impose any obligation upon the participant
to exercise such option. 
  
 15. Withholding Taxes.
Notwithstanding anything else to the contrary in the Plan, the exercise of any option shall be conditioned upon payment by such participant in cash, or other provisions satisfactory to the Committee of all local, state and federal withholding taxes
applicable, in the Committee’s judgment, to the exercise or to later disposition of shares acquired upon exercise of an option. 
  

 7 

 16. Securities Laws Compliance. Notwithstanding anything contained herein, the Corporation shall
not be obligated to grant any option under this Plan or to sell, issue or effect any transfer of any share pursuant to this Plan unless such grant, sale, issuance or transfer is at such time effectively (i) registered or exempt from registration
under the Act, and (ii) qualified or exempt from qualification under the California Corporate Securities Law of 1968 and any other applicable state securities laws. As a condition to exercise of any option, each participant shall make such
representations as may be deemed appropriate by counsel to the Corporation for the Corporation to use any available exemption from registration under the Act or qualification under any applicable state securities law. 
  
 17. Restrictive Legends. The certificates issued pursuant to this Plan
shall bear any applicable legends that may be desirable or necessary as determined in the sole and absolute discretion of the Corporation. 
  
 18. Notices. Any notice to be given under the terms of this Agreement shall be addressed to the Corporation in care of its Secretary at its
principal office, and any notice to be given to participant shall be addressed to such participant at the address maintained by the Corporation for such person or at such other address as the participant may specify in writing to the Corporation.

  
 19. Effect of Plan. The provisions of the Plan shall,
in accordance with its terms, be binding upon, and inure to the benefit of, all successors of each employee participating in the Plan, including, without limitation, such employee’s estate and the executors, administrators or trustees thereof,
heirs and legatees, and any receiver, trustee in bankruptcy or representative of creditors of such employee. 
  
 20. Arbitration. In the event of any dispute between the Corporation and a participant regarding this Plan, the dispute and any issue as to the
arbitrability of such dispute, shall be settled to the exclusion of a court of law, by arbitration in San Diego, California, by a panel of three arbitrators (each party shall choose one arbitrator and the third shall be chosen by the two arbitrators
so selected) in accordance with the Commercial Arbitration Rules of the American Arbitration Association then in effect. The decision of a majority of the arbitrators shall be final and binding upon the parties. All costs of the arbitration and the
fees of the arbitrators shall be allocated between the parties as determined by a majority of the arbitrators, it being the intention of the parties that the prevailing party in such a proceeding be made whole with respect to its expenses.

  
 21. Governing Law. This Agreement shall be governed by
the laws of the State of California. 
  
 22. Descriptive
Headings. Titles to Sections are solely for information purposes. 
  
 23. Information. All participants in the Plan shall be distributed financial statements of the Corporation at least annually. 
  
 24. Rule 16(b). To the extent required, the Plan is intended to comply with Rule 16(b)(3) of the Exchange Act as then in effect or any successor
provisions (“Rule 16(b)(3)”) and the Committee shall interpret and administer the provisions of the Plan in a manner consistent 

  

 8 

 
therewith. Any provisions inconsistent with Rule 16(b)(3) shall be inoperative and shall not affect the validity of the Plan. The Committee may establish and
adopt written administrative guidelines, designed to facilitate compliance with Section 16(b) of the Exchange Act and Rule 16(b)(3), as it may deem necessary or proper for the administration and operation of the Plan and the transaction of business
thereunder. 
  
 As adopted by the Board of Directors effective
April 12, 2001. 
  

 9

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