Document:

Exhibit 10.1

 

AMENDMENT NO. 2

TO

RELMADA THERAPEUTICS, INC. 2014 STOCK OPTION AND

EQUITY INCENTIVE PLAN, AS AMENDED

Pursuant to Section 9(a) of the 204 Stock Option and
Equity Incentive Plan, as amended (the “Plan”) of Relmada Therapeutics, Inc. (the “Company”),
the Board of Directors of the Company has duly adopted a resolution, conditioned upon approval by the stockholders of the Company,
approving this Amendment No. 2 to the Plan to increase the total number of shares of common stock, par value $.001 per share, of
the Company (the “Common Stock”) reserved and available for issuance under the Plan as follows:

1.      
Section 4(a)(i) of the Plan is hereby amended to read in its entirety as follows:

“CALCULATION OF NUMBER OF SHARES AVAILABLE. Subject
to the provisions of Section 14 of the Plan, the maximum aggregate number of Shares that may be sold under the Plan is 4,111,768
Shares of Common Stock, and the maximum aggregate number of Shares available for issuance as Incentive Stock Options is the same.
The Shares may be authorized, but unissued, or reacquired Common Stock. If an award should expire or become unexercisable for any
reason without having been exercised in full, or is surrendered pursuant to an Option Exchange Program, the unpurchased Shares
that were subject thereto shall, unless the Plan shall have been terminated, become available for future grant under the Plan.
In addition, any Shares of Common Stock which are retained by the Company upon exercise of an award in order to satisfy the exercise
or purchase price for such award or any withholding taxes due with respect to such exercise or purchase shall be treated as not
issued and shall continue to be available under the Plan. Shares issued under the Plan and later repurchased by the Company pursuant
to any repurchase right which the Company may have shall not be available for future grant under the Plan.

2.      
All other terms and provisions of the Plan shall remain unchanged and in full force and effect as written.

3.      
A majority in voting interest of the stockholders present in person or by proxy and entitled to vote at the meeting of stockholders
at which this Amendment No. 2 was considered, has duly approved this Amendment No. 2 to the Plan.

IN WITNESS WHEREOF, this Amendment No. 2 to
the Plan is made effective this 10th day of February, 2017.

	 	 	RELMADA THERAPEUTICS, INC.
	 	 	 
	 	 	By:	 	 /s/ Sergio Traversa
	 	 	Name:	 	Sergio Traversa
	 	 	Title:	 	Chief Executive OfficerEX-4.10

 Exhibit 4.10 

Issue Date:             , 2012 

THE SECURITIES REPRESENTED BY THIS INSTRUMENT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR QUALIFIED UNDER APPLICABLE STATE
SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SUCH ACT AND QUALIFIED UNDER APPLICABLE STATE SECURITIES LAWS, OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL OR OTHER
EVIDENCE, REASONABLY SATISFACTORY TO THE COMPANY AND ITS COUNSEL, THAT SUCH REGISTRATION OR QUALIFICATION IS NOT REQUIRED. 
 THE SECURITIES REPRESENTED BY
THIS INSTRUMENT ARE SUBJECT TO A LOCK-UP PERIOD OF UP TO 180 DAYS FOLLOWING THE EFFECTIVE DATE OF A REGISTRATION STATEMENT OF THE COMPANY FILED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. SUCH LOCK-UP PERIOD IS BINDING ON TRANSFEREES OF THIS
INSTRUMENT. 
 SAVARA INC. 

STOCK PURCHASE WARRANT 

THIS CERTIFIES that             (the “Holder”) is
entitled, upon the terms and subject to the conditions hereinafter set forth, to subscribe for and purchase, from Savara Inc., a Delaware corporation (the “Company”), up to
            Shares (as defined below) at an exercise price of $3.12959 per share (the “Exercise Price”). The Exercise Price and the Shares purchasable hereunder are
subject to adjustment as set forth in Section 9. This Warrant may be exercised for Shares at any time on or after the date hereof and prior the earliest to occur of (i) the close of business on May 30, 2017, (ii) the date
on which the first Change of Control (or the “effective time” if such a time is specified in connection with the transaction constituting such Change of Control (as defined below), or (iii) the date that is 360 days following the
closing of an IPO (as defined below) ((i), (ii),or (iii) as applicable, the “Expiration Date”). The Company shall provide notice to the Holder at least ten (10) days prior to the closing of a Change of Control. 

1. Definitions. 

(a) “Change of Control” shall mean (x) the acquisition of the Company by means of any transaction or series of
related transactions (including, without limitation, any stock purchase transaction, merger, consolidation or other form of reorganization in which outstanding shares of the Company are exchanged for securities or other consideration issued, or
caused to be issued, by the acquiring entity or its subsidiary, but excluding (i) any transaction effected solely for the purpose of changing the Company’s jurisdiction of incorporation and (ii) the sale by the Company of shares of
its capital stock to investors in bona fide equity financing transactions or in an IPO (as defined in the Company’s Fourth Amended and Restated Certificate of Incorporation, as amended from time to time), unless securities representing
more than fifty percent (50%) of the total combined voting power of the voting securities of the surviving or acquiring entity or its direct or indirect parent entity are immediately thereafter beneficially owned, directly or indirectly and in
substantially the same proportion, by the Company’s stockholders of record as constituted immediately prior to such transaction or series of related transactions and (y) a sale of all or substantially all of the assets of the Company in a
single transaction or series of related transactions. 

 (b) “Common Stock” shall mean the Company’s common stock, $0.001 par
value per share. 
 (c) “IPO” shall mean the Company’s first firm commitment underwritten public offering of its
Common Stock or other securities pursuant to an effective registration statement under the Securities Act of 1933, as amended (the “Securities Act”), covering the offer and sale of Common Stock to the public with aggregate
net proceeds to the Corporation of at least $20,000,000 and an offering price of at least $9.3887 per share (as adjusted to reflect any stock dividend, stock split, combination, recapitalization and other similar event with respect to each such
share). 
 (d) “Preferred Stock” shall mean the Series B Preferred Stock, par value $0.001 per share, of the Company
and any other stock into or for which the Series B Preferred Stock may be converted or exchanged, and upon and after the occurrence of an event which results in the automatic or voluntary conversion, redemption or retirement of all (but not less
than all) of the outstanding shares of such Preferred Stock, including without limitation, the consummation of an IPO in which such conversion occurs, then from and after the date upon which such outstanding shares are so converted, redeemed or
retired, “Preferred Stock” shall mean such Common Stock. 
 (e) “Securities” shall mean this Warrant and
the Shares issuable upon exercise of this Warrant. 
 (f) “Shares” shall mean shares of Preferred Stock. 

2. Exercise of Warrant. 

(a) The purchase rights represented by this Warrant are exercisable by the Holder, in whole or in part, by the surrender of this Warrant and
the Notice of Exercise annexed hereto duly executed at the principal executive office of the Company (or such other office or agency of the Company as it may designate by notice in writing to the Holder at the address of the Holder appearing on the
books of the Company), and upon payment of the Exercise Price of the Shares thereby purchased (by cash or by check or bank draft payable to the order of the Company); whereupon the Holder shall be entitled to receive a certificate for the number of
Shares so purchased. The Company agrees that if at the time of the surrender of this Warrant and purchase of the Shares, the Holder shall be entitled to exercise this Warrant, the Shares so purchased shall be and be deemed to be issued to the Holder
as the record owner of such Shares as of the close of business on the date on which this Warrant shall have been exercised as aforesaid. 

(b) In lieu of exercising this Warrant by payment of cash or check pursuant to subsection (a) above, the Holder may elect to
receive Shares equal to the value of the Warrant (based upon the value of the Shares or the portion thereof being exercised), at any time after the date hereof and before the close of business on the Expiration Date, by surrender of this Warrant at
the principal executive office of the Company, together with the Notice of Conversion annexed hereto, in which event the Company will issue to the Holder Shares in accordance with the following formula: 

  
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		 	X	  	=	  	Y(A-B)	  	
	 	  	  	A	  	

  

									
		 	Where,	  	X	  	=	  	the number of Shares to be issued to the Holder;
					
		 		  	Y	  	=	  	the number of Shares for which the Warrant is being exercised;
					
		 		  	A	  	=	  	the fair market value of one Share; and
					
		 		  	B	  	=	  	the Exercise Price.

 For purposes of this Section 2(b), the fair market value of a Share is defined as follows: 

(i) if the exercise is in connection with an initial public offering of the Common Stock, and if the Company’s registration statement
relating to such offering has been declared effective by the Securities and Exchange Commission, then the fair market value shall be the initial “Price to Public” specified in the final prospectus with respect to the offering; 

(ii) if the exercise occurs prior to the date of the Company’s initial public offering of Common Stock, the fair market value shall be
determined in good faith by the Board of Directors of the Company based on relevant facts and circumstances at the time of the net exercise under this Section 2(b); 

(iii) if the exercise is in connection with a Change of Control, then the fair market value shall be the value received in such Change of
Control by the holders of the securities as to which purchase rights under this Warrant exist; 
 (iv) if the exercise occurs after, and not
in connection with the Company’s initial public offering, and: 
 (A) if traded on a securities exchange or the Nasdaq Stock Market,
the value shall be deemed to be the average of the closing prices of the securities on such exchange or market over the thirty (30) day period ending three (3) days prior to the date of the Notice of Conversion; or 

(B) if actively traded over-the-counter, the value shall be deemed to be the average of the closing bid prices over the thirty (30) day
period ending three (3) days prior to the date of the Notice of Conversion; 

  
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 (C) if there is no active public market, the value shall be the fair market value thereof, as
determined in good faith by the Company’s Board of Directors. 
 3. Nonassessable. The Company covenants that all Shares
which may be issued upon the exercise of rights represented by this Warrant will, upon exercise of the rights represented by this Warrant, be validly issued, fully paid and nonassessable and free from all taxes, liens and charges in respect of the
issue thereof (other than taxes in respect of any transfer occurring contemporaneously with such issue). Certificates for Shares purchased hereunder shall be delivered to the Holder within a reasonable time after the date on which this Warrant shall
have been exercised as aforesaid. 
 4. No Fractional Shares or Scrip. No fractional shares or scrip representing fractional
shares shall be issued upon the exercise of this Warrant. With respect to any fraction of a share called for upon the exercise of this Warrant, an amount equal to such fraction multiplied by the then current price at which each Share may be
purchased hereunder shall be paid in cash to the Holder. 
 5. Charges, Taxes and Expenses. Issuance of certificates for Shares
upon the exercise of this Warrant shall be made without charge to the Holder hereof for any issue or transfer tax or other incidental expense in respect of the issuance of such certificate, all of which taxes and expenses shall be paid by the
Company, and such certificates shall be issued in the name of the Holder. 
 6. No Rights as Stockholder. This Warrant does not
entitle the Holder to any voting rights or other rights as a stockholder of the Company prior to the exercise hereof. 
 7. Loss,
Theft, Destruction or Mutilation of Warrant. On receipt of evidence satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity
agreement satisfactory in form and substance to the Company or, in the case of mutilation, on surrender and cancellation of this Warrant, the Company at its expense shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor and
amount. 
 8. Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of
any right required or granted herein shall be a Saturday, a Sunday or a legal holiday, then such action may be taken or such right may be exercised on the next succeeding day not a Saturday, Sunday or legal holiday. 

9. Adjustments. The Exercise Price and the number of Shares purchasable hereunder are subject to adjustment from time to time as
set forth in this Section 9. 
 (a) Reclassification, etc. If the Company, at any time while this Warrant, or any
portion hereof, remains outstanding and unexpired by reclassification of securities or otherwise, shall change any of the securities as to which purchase rights under this Warrant exist into the same or a different number of securities or any other
class or classes, this Warrant shall thereafter represent the right to acquire such number and kind of securities as would have been issuable as the result of such change with respect to the securities that were subject to the purchase rights under
this Warrant immediately prior to such reclassification or other change and the Exercise Price therefor shall be appropriately adjusted, all subject to further adjustment as provided in this Section 9. 

  
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 (b) Subdivision or Combination of Shares. In the event that the Company shall at
any time subdivide the outstanding securities as to which purchase rights under this Warrant exist, or shall issue a stock dividend on the securities as to which purchase rights under this Warrant exist, the number of securities as to which purchase
rights under this Warrant exist immediately prior to such subdivision or to the issuance of such stock dividend shall be proportionately increased, and the Exercise Price shall be proportionately decreased, and in the event that the Company shall at
any time combine the outstanding securities as to which purchase rights under this Warrant exist, the number of securities as to which purchase rights under this Warrant exist immediately prior to such combination shall be proportionately decreased,
and the Exercise Price shall be proportionately increased, effective at the close of business on the date of such subdivision, stock dividend or combination, as the case may be. 

(c) Cash Distributions. No adjustment on account of cash dividends or interest on the securities as to which purchase rights
under this Warrant exist will be made to the Exercise Price under this Warrant. 
 10. Restrictions on Transferability of
Securities. 
 (a) Restrictions on Transferability. The Securities shall not be sold, assigned, transferred or pledged
except upon the conditions specified in this Section 10. 
 (b) Restrictive Legend. Each certificate representing
the Securities and any other securities issued in respect of the Securities upon any stock split, stock dividend, recapitalization, merger, consolidation or similar event, shall (unless otherwise permitted by the provisions of
Section 10(c)) be stamped or otherwise imprinted with a legend in the following form (in addition to any legend required under applicable state securities laws): 

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR QUALIFIED UNDER
APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SUCH ACT AND QUALIFIED UNDER APPLICABLE STATE SECURITIES LAWS, OR UNLESS THE CORPORATION HAS RECEIVED AN OPINION
OF COUNSEL OR OTHER EVIDENCE, REASONABLY SATISFACTORY TO THE CORPORATION AND ITS COUNSEL, THAT SUCH REGISTRATION OR QUALIFICATION IS NOT REQUIRED. 

THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A LOCK-UP PERIOD OF UP TO 180 DAYS FOLLOWING THE EFFECTIVE DATE OF A REGISTRATION
STATEMENT OF THE COMPANY FILED UNDER THE 

  
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SECURITIES ACT OF 1933, AS AMENDED, AS SET FORTH IN THAT CERTAIN STOCK PURCHASE WARRANT BETWEEN THE CORPORATION AND THE ORIGINAL HOLDER OF THESE SECURITIES, A COPY OF WHICH MAY BE OBTAINED AT THE
CORPORATION’S PRINCIPAL OFFICE. SUCH LOCK-UP PERIOD IS BINDING ON TRANSFEREES OF THESE SECURITIES. 
 Each holder of Securities and
each subsequent transferee consents to the Company making a notation on its records and giving instructions to any transfer agent of the Securities in order to implement the restrictions on transfer established in this Section 10. 

(c) Notice of Proposed Transfers. Each holder of a warrant or stock certificate, as the case may be, representing the Securities,
by acceptance thereof, agrees to comply in all respects with the provisions of this Section 10(c). Such holder agrees not to make any disposition of all or any portion of the Securities unless and until (X) there is then in effect a
registration statement under the Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement or (Y) such holder shall have notified the Company of the proposed disposition and
shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and if reasonably requested by the Company, such holder shall have furnished the Company with an opinion of counsel, reasonably
satisfactory to the Company that such disposition will not require registration of such shares under the Securities Act. Notwithstanding the foregoing, the prior written approval of the Company shall not necessary for any assignment or transfer of
Securities from a Holder to an assignee that (i) is a subsidiary, parent, member, partner, limited partner, retired partner, grantor or shareholder of a Holder, (ii) an investment fund managed by a Holder or the directors, officers,
partners or members of such Holder, or (iii) is a Holder’s family member or trust for the benefit of an individual Holder provided that: (a) the Company is, within a reasonable time after such transfer, furnished with written
notice of the name and address of such transferee or assignee and the Securities being assigned; and (b) such transferee or assignee agrees in writing to be bound by and subject to the terms and conditions of this Warrant if this Warrant is
still outstanding. 
 11. Investment Representations of the Holder. With respect to the acquisition of any of the Securities,
the Holder hereby represents and warrants to the Company as follows: 
 (a) Purchase Entirely for Own Account. This Warrant is
made with the Holder in reliance upon the Holder’s representation to the Company, which by the Holder’s execution of this Warrant the Holder hereby confirms, that the Securities will be acquired for investment for the Holder’s own
account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that the Holder has no present intention of selling, granting any participation in, or otherwise distributing the same. By executing this
Warrant, the Holder further represents that the Holder does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participations to such person or to any third person with respect to any of the
Securities. 

  
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 (b) Reliance upon Holders’ Representations. The Holder understands that the
Securities have not been, and will not be, registered under the Securities Act by reason of a specific exemption from the registration provisions of the Securities Act, and that the Company’s reliance on such exemption is predicated on the
Holder’s representations set forth herein. 
 (c) Investment Experience; Economic Risk. The Holder understands that the
Company has a limited financial and operating history and that an investment in the Company involves substantial risks. The Holder is experienced in evaluating and investing in private placement transactions of securities of companies in a similar
stage of development to that of the Company and acknowledges that the Holder is able to fend for himself, herself or itself. The Holder has such knowledge and experience in financial and business matters that the Holder is capable of evaluating the
merits and risks of the investment in the Securities. The Holder can bear the economic risk of the Holder’s investment and is able, without impairing the Holder’s financial condition, to hold the Securities for an indefinite period of time
and to suffer a complete loss of the Holder’s investment. 
 (d) Accredited Investor Status. The Holder is an
“accredited investor” within the meaning of Regulation D, Rule 501(a), promulgated under the Securities Act. If other than an individual, the Holder also represents that it has not been organized for the purpose of acquiring the
Securities. 
 (e) Representations by Foreign Holder. If Holder is not a United States person, such Holder hereby represents
that such Holder has satisfied himself, herself or itself as to the full observance of the laws of such Holder’s jurisdiction in connection with any invitation to subscribe for the Securities purchasable hereunder, including (i) the legal
requirements within such Holder’s jurisdiction for the purchase of the Securities, (ii) any foreign exchange restrictions applicable to such purchase, (iii) any governmental or other consents that may need to be obtained and
(iv) the income tax and other tax consequences, if any, that may be relevant to the purchase, holding, redemption, sale, or transfer of the Securities purchasable hereunder. Such Holder’s subscription and payment for, and such
Holder’s continued beneficial ownership of the Securities purchasable hereunder, will not violate any applicable securities or other laws of such Holder’s jurisdiction. 

(f) Restricted Securities. The Holder understands that the Securities are characterized as “restricted securities”
under the federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that under such federal securities laws and applicable regulations such Securities may be resold without
registration under the Securities Act only in certain limited circumstances. In this connection, Holder represents that it is aware of the provisions of Rule 144 promulgated under the Securities Act which permit limited resale of securities
purchased in a private placement subject to the satisfaction of certain conditions, including, among other things, the existence of a public market for the securities, the availability of certain current public information about the Company, the
resale occurring not less than one year after a party has purchased and paid for the security to be sold, the sale being effected through a “broker’s transaction” or in transactions directly with a “market maker” and the
number of shares being sold during any three-month period not exceeding specified limitations. 
 12. Market Standoff. Holder
agrees to be bound (and shall cause any transferee of this Warrant to be bound) by the “Market Stand-off Agreements” provisions set forth in Section 2.11 of the Third Amended and Restated Investors’ Rights Agreement by and
between the Company and the signatories thereto, as may be amended from time to time. 

  
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 13. Notices. In the event (i) the Company shall take a record of the holders
of the securities at the time receivable upon the exercise of this Warrant for the purpose of entitling them to receive any dividend or other distribution, or any right to subscribe for or purchase any shares of stock of any class or any other
securities, or to receive any other right, (ii) of any capital reorganization of the Company, (iii) of any reclassification of the capital stock of the Company, or (iv) of any voluntary dissolution, liquidation or winding-up of the
Company, then, and in each such case, the Company will mail or cause to be mailed to the Holder a notice specifying, as the case may be, (A) the date on which a record is to be taken for the purpose of such dividend, distribution or right, and
stating the amount and character of such dividend, distribution or right, or (B) the date on which such reorganization, reclassification, dissolution, liquidation or winding-up is to take place, and the time, if any is to be fixed, as of which
the holders of the securities at the time receivable upon the exercise of this Warrant shall be entitled to exchange such securities for the securities or other property deliverable upon such reorganization, reclassification, dissolution,
liquidation or winding-up. Such notice shall be given at least ten (10) days prior to the date therein specified. 
 14.
Miscellaneous. 
 (a) Governing Law. THIS AGREEMENT SHALL BE GOVERNED IN ALL RESPECTS BY THE LAWS OF THE STATE OF
DELAWARE, WITHOUT REGARD TO CONFLICT OF LAWS RULES. 
 (b) Waivers and Amendments. This Warrant and any provisions hereof may
be changed, waived, discharged or terminated only by an instrument in writing signed by the party against which enforcement of the same is sought. 

(c) Assignment. This Warrant may be assigned or transferred by the Holder only with the prior written approval of the Company.
Notwithstanding the foregoing, the prior written approval of the Company shall not necessary for any assignment or transfer from a Holder to an assignee that (i) is a subsidiary, parent, member, partner, limited partner, retired partner,
grantor or shareholder of a Holder, (ii) an investment fund managed by a Holder or the directors, officers, partners or members of such Holder, or (iii) is a Holder’s family member or trust for the benefit of an individual Holder
provided that: (a) the Company is, within a reasonable time after such transfer, furnished with written notice of the name and address of such transferee or assignee; and (b) such transferee or assignee agrees in writing to be bound
by and subject to the terms and conditions of this Warrant. This Warrant shall be binding upon any successors or assigns of the Company. 

(d) Notices. All notices and other communications hereunder shall be in writing and shall be deemed given if delivered
personally, by commercial delivery service, mailed by registered or certified mail (return receipt requested), sent via facsimile (with confirmation of receipt) or electronic mail to the parties at the address for each party as set forth on the
signature page hereto (or at such other address for a party as such party may designate pursuant to this Section 14(d)). 

Notice given by personal delivery, courier service or mail shall be effective upon actual receipt. Notice given by facsimile shall be
effective upon actual receipt if received during the recipients normal business hours, or at the beginning of the recipient’s next business day after receipt if not received during the recipient’s normal business hours. All notices by
facsimile shall be confirmed by the sender promptly after transmission via certified mail or personal delivery. Any party may change any address to which notice is to be given to it by giving notice as provided above or such change of address. 

  
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 An electronic communication (“Electronic Notice”) shall be deemed written
notice for purposes of this Section 14(d) if sent with return receipt requested to the electronic mail address specified by the receiving party in a signed writing in a nonelectronic form. Electronic Notice shall be deemed received at
the time the party sending Electronic Notice receives verification of receipt by the receiving party. Any party receiving Electronic Notice may request and shall be entitled to receive the notice on paper, in a nonelectronic form
(“Nonelectronic Notice”) which shall be sent to the requesting party within ten (10) days of receipt of the written request for Nonelectronic Notice. This Warrant may be executed in any number of counterparts, each of
which shall be enforceable, and all of which together shall constitute one instrument. 
 (e) Counterparts. This Warrant may be
executed in any number of counterparts, each of which shall be enforceable, and all of which together shall constitute one instrument. 
 (f)
Delays or Omissions. No delay or omission to exercise any right, power, or remedy accruing to the Holder, upon any breach or default of the Company under this Warrant shall impair any such right, power, or remedy of the Holder nor
shall it be construed to be a waiver of any such breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other
breach or default therefore or thereafter occurring. Any waiver, permit, consent, or approval of any kind or character on the part of the Holder of any breach or default under this Warrant or any waiver on the part of the Holder of any provisions or
conditions of this Warrant must be made in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Warrant or by law or otherwise afforded to the Holder, shall be cumulative and not
alternative. 
 (g) Titles and Subtitles. The titles of the paragraphs and subparagraphs of this Warrant are for convenience of
reference only and are not to be considered in construing this Warrant. 
 (h) Lost Warrants or Stock Certificates. Upon
receipt of evidence reasonably satisfactory to the Company of the loss, theft, destruction, or mutilation of any Warrant or stock certificate and, in the case of any such loss, theft or destruction, upon receipt of an indemnity reasonably
satisfactory to the Company, or in the case of any such mutilation upon surrender and cancellation of such Warrant or stock certificate, the Company at its expense will make and deliver a new Warrant or stock certificate, of like tenor, in lieu of
the lost, stolen, destroyed or mutilated Warrant or stock certificate provided, however, that, if the Company’s stock is publicly traded, the Company may require the posting of a bond in an amount and nature as is customary and reasonable given
the circumstances. 

  
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 IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by its officer thereunto
duly authorized. 
  

	
	SAVARA INC.
	
	By:                                     
                                         
                  
	Name:                                     
                                         
            
	Title:                                     
                                         
              

  

	
	AGREED AND ACKNOWLEDGED:
	
	“Holder”
	
	  

	(Signature)
	
	  

	(Print Name)
	
	  

	(Title if signing of behalf of an entity)
	
	Address*:
	  

	  

	  

	Phone #:                                   
                                    
	Facsimile #:                                  
                                
	Email:                                    
                                       

 *  Please indicate address for notice purposes. 

SAVARA INC. 

STOCK PURCHASE WARRANT 

SIGNATURE PAGE 

 NOTICE OF EXERCISE 

 

	TO:	Savara Inc. 

 5900 Shepherd Mountain Cove #2-205 

Austin, Texas 78730 
 ATTN: Chief
Executive Officer 
 1. The undersigned hereby elects to purchase
            shares of the             Stock (the “Shares”) of Savara Inc. (the
“Company”) pursuant to the terms of the attached Warrant, and tenders herewith payment of the purchase price in full. 

2. Please issue a certificate or certificates representing the Shares in the name of the undersigned or in such other name as is specified
below: 
  

					
		 	  
 (Print Name)
	 	
			
		 	 Address:
	 	
			
		 	  
	 	

 3. Investment Representations. With respect to the acquisition of any of the Shares, the undersigned
hereby represents and warrants to the Company as follows: 
 (a) Purchase Entirely for Own Account. The undersigned confirms that the
Shares are being acquired for the account of the undersigned, not as a nominee or agent, for investment only and not with a view to the resale or distribution of any part thereof, and that the undersigned has no present intention of selling,
granting any participation in, or otherwise distributing the same. The undersigned further represents that the he, she or it does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participations
to such person or to any third person with respect to any of the Shares. 
 (b) Reliance upon Undersigned’s Representations. The
undersigned understands that the Shares have not been, and will not be, registered under the Securities Act of 1933, as amended (the “Securities Act”) by reason of a specific exemption from the registration provisions of the
Securities Act, and that the Company’s reliance on such exemption is predicated on the undersigned’s representations set forth herein. 

(c) Investment Experience; Economic Risk. The undersigned understands that the Company has a limited financial and operating history and
that an investment in the Company involves substantial risks. The undersigned is experienced in evaluating and investing in private placement transactions of securities of companies in a similar stage of development to that of the

 
Company and acknowledges that the undersigned is able to fend for himself, herself or itself. The undersigned has such knowledge and experience in financial and business matters that the
undersigned is capable of evaluating the merits and risks of the investment in the Shares. The undersigned can bear the economic risk of the undersigned’s investment and is able, without impairing the undersigned’s financial condition, to
hold the Shares for an indefinite period of time and to suffer a complete loss of the undersigned’s investment. 
 (d) Accredited
Investor Status. The undersigned is an “accredited investor” within the meaning of Regulation D, Rule 501(a), promulgated under the Securities Act. If other than an individual, the undersigned also represents that it has not been
organized for the purpose of acquiring the Shares. 
 (e) Representations by Foreign Investor. If the undersigned is not a United
States person, such undersigned hereby represents that such he, she or it has satisfied himself, herself or itself as to the full observance of the laws of such undersigned’s jurisdiction in connection with any invitation to subscribe for the
Shares purchasable hereunder, including (i) the legal requirements within such undersigned’s jurisdiction for the purchase of the Shares, (ii) any foreign exchange restrictions applicable to such purchase, (iii) any governmental
or other consents that may need to be obtained and (iv) the income tax and other tax consequences, if any, that may be relevant to the purchase, holding, redemption, sale, or transfer of the Shares purchasable hereunder. Such undersigned’s
subscription and payment for, and such undersigned’s continued beneficial ownership of the Shares, will not violate any applicable securities or other laws of such undersigned’s jurisdiction. 

(f) Restricted Securities. The undersigned understands that the Shares are characterized as “restricted securities” under the
federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that under such federal securities laws and applicable regulations such Shares may be resold without registration under
the Securities Act only in certain limited circumstances. In this connection, undersigned represents that it is aware of the provisions of Rule 144 promulgated under the Securities Act which permit limited resale of securities purchased in a private
placement subject to the satisfaction of certain conditions, including, among other things, the existence of a public market for the securities, the availability of certain current public information about the Company, the resale occurring not less
than one year after a party has purchased and paid for the security to be sold, the sale being effected through a “broker’s transaction” or in transactions directly with a “market maker” and the number of shares being sold
during any three-month period not exceeding specified limitations. 
  

					
	  
 (Date)
	 		  	  
 (Signature)

		 		  	  

		 		  	(Print Name)

  

 NOTICE OF CONVERSION 

 

	TO:	Savara Inc. 

 5900 Shepherd Mountain Cove #2-205 

Austin, Texas 78730 
 ATTN: Chief
Executive Officer 
 1. The undersigned hereby elects to convert the attached Warrant into
            shares of the             Stock (the “Shares”) of Savara Inc. pursuant to
Section 2(b) of such Warrant, which conversion shall be effected pursuant to the terms of the attached Warrant. 
 2. Please
issue a certificate or certificates representing the Shares in the name of the undersigned or in such other name as is specified below: 
  

					
		 	  
 (Print Name)
	 	
			
		 	 Address:
	 	
			
		 	  
	 	

 3. Investment Representations. With respect to the acquisition of any of the Shares, the undersigned
hereby represents and warrants to the Company as follows: 
 (a) Purchase Entirely for Own Account. The undersigned confirms that the
Shares are being acquired for the account of the undersigned, not as a nominee or agent, for investment only and not with a view to the resale or distribution of any part thereof, and that the undersigned has no present intention of selling,
granting any participation in, or otherwise distributing the same. The undersigned further represents that the he, she or it does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participations
to such person or to any third person with respect to any of the Shares. 
 (b) Reliance upon Undersigned’s Representations. The
undersigned understands that the Shares have not been, and will not be, registered under the Securities Act of 1933, as amended (the “Securities Act”) by reason of a specific exemption from the registration provisions of the
Securities Act, and that the Company’s reliance on such exemption is predicated on the undersigned’s representations set forth herein. 

(c) Investment Experience; Economic Risk. The undersigned understands that the Company has a limited financial and operating history and
that an investment in the Company involves substantial risks. The undersigned is experienced in evaluating and investing in private placement transactions of securities of companies in a similar stage of development to that of the

 
Company and acknowledges that the undersigned is able to fend for himself, herself or itself. The undersigned has such knowledge and experience in financial and business matters that the
undersigned is capable of evaluating the merits and risks of the investment in the Shares. The undersigned can bear the economic risk of the undersigned’s investment and is able, without impairing the undersigned’s financial condition, to
hold the Shares for an indefinite period of time and to suffer a complete loss of the undersigned’s investment. 
 (d) Accredited
Investor Status. The undersigned is an “accredited investor” within the meaning of Regulation D, Rule 501(a), promulgated under the Securities Act. If other than an individual, the undersigned also represents that it has not been
organized for the purpose of acquiring the Shares. 
 (e) Representations by Foreign Investor. If the undersigned is not a United
States person, such undersigned hereby represents that such he, she or it has satisfied himself, herself or itself as to the full observance of the laws of such undersigned’s jurisdiction in connection with any invitation to subscribe for the
Shares purchasable hereunder, including (i) the legal requirements within such undersigned’s jurisdiction for the purchase of the Shares, (ii) any foreign exchange restrictions applicable to such purchase, (iii) any governmental
or other consents that may need to be obtained and (iv) the income tax and other tax consequences, if any, that may be relevant to the purchase, holding, redemption, sale, or transfer of the Shares purchasable hereunder. Such undersigned’s
subscription and payment for, and such undersigned’s continued beneficial ownership of the Shares, will not violate any applicable securities or other laws of such undersigned’s jurisdiction. 

(f) Restricted Securities. The undersigned understands that the Shares are characterized as “restricted securities” under the
federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that under such federal securities laws and applicable regulations such Shares may be resold without registration under
the Securities Act only in certain limited circumstances. In this connection, undersigned represents that it is aware of the provisions of Rule 144 promulgated under the Securities Act which permit limited resale of securities purchased in a private
placement subject to the satisfaction of certain conditions, including, among other things, the existence of a public market for the securities, the availability of certain current public information about the Company, the resale occurring not less
than one year after a party has purchased and paid for the security to be sold, the sale being effected through a “broker’s transaction” or in transactions directly with a “market maker” and the number of shares being sold
during any three-month period not exceeding specified limitations. 
  

					
	  
 (Date)
	 		  	  
 (Signature)

			
		 		  	  

		 		  	(Print Name)

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