Document:

Loan and Security Agreement

 Exhibit 10.1 
 LIGAND PHARMACEUTICALS, INCORPORATED 
 LOAN AND SECURITY AGREEMENT

 This LOAN AND SECURITY AGREEMENT (the “Agreement”) is entered into as of
March 31, 2011, by and between Square 1 Bank (“Bank”) and LIGAND PHARMACEUTICALS, INCORPORATED (“Borrower”). 
 RECITALS 
 Borrower wishes to obtain credit from time to time from Bank,
and Bank desires to extend credit to Borrower. This Agreement sets forth the terms on which Bank will advance credit to Borrower, and Borrower will repay the amounts owing to Bank. 

AGREEMENT 
 The parties
agree as follows: 
  

	 	1.	DEFINITIONS AND CONSTRUCTION. 

 1.1 Definitions. As used in this Agreement, all capitalized terms shall have the definitions set forth on Exhibit A. Any term used in the Code and not defined herein shall have the meaning
given to the term in the Code. 
 1.2 Accounting Terms. Any accounting term not specifically defined on Exhibit A
shall be construed in accordance with GAAP and all calculations shall be made in accordance with GAAP. The term “financial statements” shall include the accompanying notes and schedules. 

 

	 	2.	LOAN AND TERMS OF PAYMENT. 

2.1 Credit Extensions. 
 (a) Promise to Pay. Borrower promises to pay to Bank, in lawful money of the United States of America, the aggregate unpaid principal amount of all Credit Extensions made by Bank to
Borrower, together with interest on the unpaid principal amount of such Credit Extensions at rates in accordance with the terms hereof. 
 (b) Advances Under Revolving Line. 
 (i) Amount.
Subject to and upon the terms and conditions of this Agreement (1) Borrower may request Advances in an aggregate outstanding principal amount not to exceed the Revolving Line and (2) amounts borrowed pursuant to this
Section 2.1(b) may be repaid and reborrowed at any time prior to the Revolving Maturity Date, at which time all Advances under this Section 2.1(b) shall be immediately due and payable. Borrower may prepay any Advances without penalty or
premium. 
 (ii) Form of Request. Whenever Borrower desires an Advance, Borrower will notify Bank by facsimile
transmission, telephone or email no later than 3:30 p.m. Eastern time (2:30 p.m. Eastern time for wire transfers), on the Business Day that the Advance is to be made. Each such notification shall be promptly confirmed by a Loan Advance/Paydown
Request Form in substantially the form of Exhibit B. Bank is authorized to make Advances under this Agreement, based upon instructions received from an Authorized Officer or a designee of an Authorized Officer, or without instructions if in
Bank’s discretion such Advances are necessary to meet Obligations which have become due and remain unpaid. Bank shall be entitled to rely on any telephonic or email notice given by a person whom Bank reasonably believes to be an Authorized
Officer or a designee thereof, and Borrower shall indemnify and hold Bank harmless for any damages, loss, costs and expenses suffered by Bank as a result of such reliance. Bank will credit the amount of Advances made under this Section 2.1(b)
to Borrower’s deposit account. 
 2.2 Intentionally Omitted. 

  
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 2.3 Interest Rates, Payments, and Calculations. 

(a) Interest Rate for Advances. Except as set forth in Section 2.3(b), the Advances shall bear interest, on the
outstanding daily balance thereof, at a variable annual rate equal to 2.00% above the Prime Rate then in effect. 
 (b)
Late Fee; Default Rate. If any payment is not made within 15 days after the date such payment is due, Borrower shall pay Bank a late fee equal to the lesser of (i) 5% of the amount of such unpaid amount or (ii) the maximum amount
permitted to be charged under applicable law. All Obligations shall bear interest, from and after the occurrence and during the continuance of an Event of Default, at a rate equal to 5 percentage points above the interest rate applicable immediately
prior to the occurrence of the Event of Default. 
 (c) Payments. Interest under the Revolving Line shall be due
and payable on the first calendar day of each month during the term hereof. Bank may, if not otherwise paid by Borrower when due, charge such interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts or
against the Revolving Line, in which case those amounts shall thereafter accrue interest at the rate then applicable hereunder. Any interest not paid when due shall be compounded by becoming a part of the Obligations, and such interest shall
thereafter accrue interest at the rate then applicable hereunder. 
 (d) Computation. In the event the Prime Rate
is changed from time to time hereafter, the applicable rate of interest hereunder shall be increased or decreased, effective as of the day the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest chargeable under
the Loan Documents shall be computed on the basis of a 360 day year for the actual number of days elapsed. 
 2.4
Crediting Payments. Prior to the occurrence of an Event of Default, Bank shall credit a wire transfer of funds, check or other item of payment to such deposit account or Obligation as Borrower specifies. After the occurrence and during the
continuance of an Event of Default, Bank shall have the right, in its sole discretion, to immediately apply any wire transfer of funds, check, or other item of payment Bank may receive to conditionally reduce Obligations, but such applications of
funds shall not be considered a payment on account unless such payment is of immediately available federal funds or unless and until such check or other item of payment is honored when presented for payment. Notwithstanding anything to the contrary
contained herein, any wire transfer or payment received by Bank after 5:30 p.m. Eastern time shall be deemed to have been received by Bank as of the opening of business on the immediately following Business Day. Whenever any payment to Bank under
the Loan Documents would otherwise be due (except by reason of acceleration) on a date that is not a Business Day, such payment shall instead be due on the next Business Day, and additional fees or interest, as the case may be, shall accrue and be
payable for the period of such extension. 
 2.5 Fees. Borrower shall pay to Bank the following: 

(a) Facility Fee. On or before the Closing Date, a fee equal to $20,000, which shall be nonrefundable; 

(b) Bank Expenses. On the Closing Date, all Bank Expenses incurred through the Closing Date, provided that legal expenses
incurred in preparation of the Loan Documents shall be no more than $15,000. After the Closing Date, all Bank Expenses, as and when they become due. 
 2.6 Term. This Agreement shall become effective on the Closing Date and, subject to Section 12.7, shall continue in full force and effect for so long as any Obligations remain
outstanding or Bank has any obligation to make Credit Extensions under this Agreement. Notwithstanding the foregoing, Bank shall have the right to terminate its obligation to make Credit Extensions under this Agreement immediately and without notice
upon the occurrence and during the continuance of an Event of Default. 

  
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	 	3.	CONDITIONS OF LOANS. 

3.1 Conditions Precedent to Closing. The agreement of Bank to enter into this Agreement as of the Closing Date is subject to
the condition precedent that Bank shall have received, in form and substance satisfactory to Bank, each the following items and completed each of the following requirements: 
 (a) this Agreement; 
 (b) an officer’s certificate of Borrower
with respect to incumbency and resolutions authorizing the execution and delivery of this Agreement; 
 (c) payment of
the fees and Bank Expenses then due specified in Section 2.5, which may be debited from any of Borrower’s accounts with Bank; 
 (d) a Borrower Information Certificate; 
 (e) Borrower shall open
and fund not less than $5,000,000 in the Cash Security Account as collateral for Borrower’s Obligations hereunder; 

(f) Borrower shall open and fund not less than $10,000 in deposit accounts held with Bank, such amount being exclusive of the
Cash Security Account for Obligations provided hereunder as referenced in Section 3.1(e) above; and 
 (g) such
other documents or certificates, and completion of such other matters, as Bank may reasonably request, 
 3.2
Conditions Precedent to all Credit Extensions. The obligation of Bank to make each Credit Extension, including the initial Credit Extension, is contingent upon Borrower’s compliance with Section 3.1 above, and is further subject to
the following conditions: 
 (a) timely receipt by Bank of the Loan Advance/Paydown Request Form as provided in
Section 2.1; and 
 (b) the representations and warranties contained in Section 5 shall be true and correct in
all material respects on and as of the date of such Loan Advance/Paydown Request Form and on the effective date of each Credit Extension as though made at and as of each such date, and no Event of Default shall have occurred and be continuing, or
would exist after giving effect to such Credit Extension (provided, however, that those representations and warranties expressly referring to another date shall be true, correct and complete in all material respects as of such date). The making of
each Credit Extension shall be deemed to be a representation and warranty by Borrower on the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2. 

 

	 	4.	CREATION OF SECURITY INTEREST. 

 4.1 Grant of Security Interest. Borrower grants and pledges to Bank a continuing security interest in the Collateral to secure prompt repayment of any and all Obligations and to secure
prompt performance by Borrower of each of its covenants and duties under the Loan Documents. Such security interest constitutes a valid, first priority security interest in the presently existing Collateral, and will constitute a valid, first
priority security interest in later-acquired Collateral. 
 4.2 Perfection of Security Interest. Borrower from
time to time may deposit with Bank specific cash collateral to secure specific Obligations; Borrower authorizes Bank to hold such specific balances in pledge and to decline to honor any drafts thereon or any request by Borrower or any other Person
to pay or otherwise transfer any part of such balances for so long as the specific Obligations are outstanding. Borrower shall take such other actions as Bank requests to perfect its security interest granted under this Agreement. 

  
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	 	5.	REPRESENTATIONS AND WARRANTIES. 

 Borrower represents and warrants as follows: 
 5.1 Due Organization and
Qualification. Borrower is a corporation duly existing under the laws of the state in which it is organized and qualified and licensed to do business in any state in which the conduct of its business or its ownership of property requires that it
be so qualified, except where the failure to do so would not reasonably be expected to cause a Material Adverse Effect. 

5.2 Due Authorization; No Conflict. The execution, delivery, and performance of the Loan Documents are within
Borrower’s powers, have been duly authorized, and are not in conflict with nor constitute a breach of any provision contained in Borrower’s Certificate of Incorporation or Bylaws, nor will they constitute an event of default under any
material agreement by which Borrower is bound. Borrower is not in default under any agreement by which it is bound, except to the extent such default would not reasonably be expected to cause a Material Adverse Effect. 

5.3 Collateral. Borrower has rights in or the power to transfer the Collateral. 

5.4 Name; Location of Chief Executive Office. Except as disclosed in the Schedule, Borrower has not done business under any
name other than that specified on the signature page hereof, and its exact legal name is as set forth in the first paragraph of this Agreement. The chief executive office of Borrower is located at the address indicated in Section 10 hereof.

 5.5 Litigation. Except as set forth in the Schedule, there are no actions or proceedings pending by or against
Borrower or any Subsidiary before any court or administrative agency in which a likely adverse decision would reasonably be expected to have a Material Adverse Effect. 
 5.6 No Material Adverse Change in Financial Statements. All consolidated and consolidating financial statements related to Borrower and any Subsidiary that are delivered by Borrower to Bank
fairly present in all material respects Borrower’s consolidated and consolidating financial condition as of the date thereof and Borrower’s consolidated and consolidating results of operations for the period then ended. There has not been
a material adverse change in the consolidated or in the consolidating financial condition of Borrower since the date of the most recent of such financial statements submitted to Bank. 

5.7 Solvency, Payment of Debts. Borrower is able to pay its debts (including trade debts) as they mature; the fair saleable
value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably small capital after the transactions contemplated by this Agreement. 

5.8 Compliance with Laws and Regulations. Borrower has met the minimum funding requirements of ERISA with respect to any
employee benefit plans subject to ERISA. No event has occurred resulting from Borrower’s failure to comply with ERISA that is reasonably likely to result in Borrower’s incurring any liability that could have a Material Adverse Effect.
Borrower is not an “investment company” or a company “controlled” by an “investment company” within the meaning of the Investment Company Act of 1940. Borrower is not engaged principally, or as one of its important
activities, in the business of extending credit for the purpose of purchasing or carrying margin stock (within the meaning of Regulations T and U of the Board of Governors of the Federal Reserve System). Borrower has not violated any statutes, laws,
ordinances or rules applicable to it, the violation of which would reasonably be expected to have a Material Adverse Effect. Borrower has filed or caused to be filed all tax returns required to be filed, and have paid, or have made adequate
provision for the payment of, all taxes reflected therein except those being contested in good faith with adequate reserves under GAAP or where the failure to file such returns or pay such taxes would not reasonably be expected to have a Material
Adverse Effect. 
 5.9 Government Consents. Borrower has obtained all consents, approvals and authorizations of,
made all declarations or filings with, and given all notices to, all governmental authorities that are 

  
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necessary for the continued operation of Borrower’s business as currently conducted, except where the failure to do so would not reasonably be expected to cause a Material Adverse Effect.

 5.10 Full Disclosure. No representation, warranty or other statement made by Borrower in any certificate or
written statement furnished to Bank taken together with all such certificates and written statements furnished to Bank contains any untrue statement of a material fact or omits to state a material fact necessary in order to make the statements
contained in such certificates or statements not misleading in light of the circumstances in which they were made, it being recognized by Bank that the projections and forecasts provided by Borrower in good faith and based upon reasonable
assumptions are not to be viewed as facts and that actual results during the period or periods covered by any such projections and forecasts may differ from the projected or forecasted results. 

 

	 	6.	AFFIRMATIVE COVENANTS. 

Borrower covenants that, until payment in full of all outstanding Obligations, and for so long as Bank may have any commitment to make a
Credit Extension hereunder, Borrower shall do all of the following: 
 6.1 Good Standing and Government
Compliance. Borrower shall maintain its and each of its Subsidiaries’ corporate existence and good standing in the respective states of formation, shall maintain qualification and good standing in each other jurisdiction in which the
failure to so qualify would reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the organizational identification number issued to Borrower by the authorities of the state in which Borrower is organized, if
applicable. Borrower shall meet, and shall cause each Subsidiary to meet, the minimum funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. Borrower shall comply, and shall cause each Subsidiary to comply, with
all statutes, laws, ordinances and government rules and regulations to which it is subject, and shall maintain, and shall cause each of its Subsidiaries to maintain, in force all licenses, approvals and agreements, the loss of which or failure to
comply with which would reasonably be expected to have a Material Adverse Effect. 
 6.2 Taxes. Borrower shall
make, and cause each Subsidiary to make, due and timely payment or deposit of all material federal, state, and local taxes, assessments, or contributions required of it by law, including, but not limited to, those laws concerning income taxes,
F.I.C.A., F.U.T.A. and state disability, and will execute and deliver to Bank, on demand, proof satisfactory to Bank indicating that Borrower or a Subsidiary has made such payments or deposits and any appropriate certificates attesting to the
payment or deposit thereof; provided that Borrower or a Subsidiary need not make any payment if the amount or validity of such payment is contested in good faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by
Borrower or such Subsidiary. 
 6.3 Cash Security Account. Borrower shall at all times maintain the Cash
Security Account, with a balance of Cash in such Cash Security Account at all times of not less than $5,000,000. 
 6.4
Financial Statements, Reports, Certificates. Borrower shall deliver to Bank: (i) as soon as available, but in any event within 30 days after the end of each calendar month, a company prepared consolidated and consolidating balance sheet
and income statement covering Borrower’s operations during such period, in a form reasonably acceptable to Bank and certified by a Responsible Officer; (ii) as soon as available, but in any event within 180 days after the end of
Borrower’s fiscal year, audited consolidated and consolidating financial statements of Borrower prepared in accordance with GAAP, consistently applied, together with an opinion which is either unqualified, qualified only for going concern so
long as Borrower’s investors provide additional equity as needed or otherwise consented to in writing by Bank on such financial statements of an independent certified public accounting firm reasonably acceptable to Bank; (iii) all reports
on Forms 10-K and 10-Q filed with the Securities and Exchange Commission; and (iv) such budgets, sales projections, operating plans or other financial information generally prepared by Borrower in the ordinary course of business as Bank may
reasonably request from time to time. 
 (a) Within 30 days after the last day of each month, Borrower shall deliver to
Bank with the monthly financial statements a Compliance Certificate certified as of the last day of the applicable month and signed by a Responsible Officer in substantially the form of Exhibit C hereto. 

  
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 6.5 Further Assurances. At any time and from time to time Borrower shall
execute and deliver such further instruments and take such further action as may reasonably be requested by Bank to effect the purposes of this Agreement. 
  

	 	7.	NEGATIVE COVENANTS. 

Borrower covenants and agrees that, so long as any credit hereunder shall be available and until the outstanding Obligations are paid in
full or for so long as Bank may have any commitment to make any Credit Extensions, Borrower will not do any of the following without Bank’s prior written consent, which shall not be unreasonably withheld: 

7.1 Change in Name, Location or Executive Office; Change in Business; Change in Fiscal Year; Change in Control. Change its
name or the state of Borrower’s formation or relocate its chief executive office without 30 days prior written notification to Bank; engage in any business, or permit any of its Subsidiaries to engage in any business, other than or reasonably
related or incidental to the businesses currently engaged in by Borrower; change its fiscal year end; have a Change in Control. 
  

	 	8.	EVENTS OF DEFAULT. 

 Any
one or more of the following events shall constitute an Event of Default by Borrower under this Agreement: 
 8.1
Payment Default. If Borrower fails to pay any of the Obligations when due; 
 8.2 Other Defaults.

 (a) If Borrower fails to perform any obligation under Section 6.2 (Taxes), Section 6.3 (Cash Security
Account), Section 6.4 (Financial Statements, Reports, Certificates), or violates any of the covenants contained in Article 7 of this Agreement; or 
 (b) If Borrower fails or neglects to perform or observe any other material term, provision, condition, covenant contained in this Agreement, in any of the Loan Documents, or in any other present or
future agreement between Borrower and Bank and as to any default under such other term, provision, condition or covenant that can be cured, has failed to cure such default within 10 days after Borrower receives notice thereof or any officer of
Borrower becomes aware thereof; provided, however, that if the default cannot by its nature be cured within the 10 day period or cannot after diligent attempts by Borrower be cured within such 10 day period, and such default is likely to be cured
within a reasonable time, then Borrower shall have an additional reasonable period (which shall not in any case exceed 30 days) to attempt to cure such default, and within such reasonable time period the failure to have cured such default shall not
be deemed an Event of Default but no Credit Extensions will be made; 
 8.3 Material Adverse Change. If there
occurs any circumstance or any circumstances which would reasonably be expected to have a Material Adverse Effect; 
 8.4
Attachment. If any material portion of Borrower’s assets is attached, seized, subjected to a writ or distress warrant, or is levied upon, or comes into the possession of any trustee, receiver or person acting in a similar capacity and
such attachment, seizure, writ or distress warrant or levy has not been removed, discharged or rescinded within 10 days, or if Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct all or any material
part of its business affairs, or if a judgment or other claim becomes a lien or encumbrance upon any material portion of Borrower’s assets, or if a notice of lien, levy, or assessment is filed of record with respect to any material portion of
Borrower’s assets by the United States Government, or any department, agency, or instrumentality thereof, or by any state, county, municipal, or governmental agency, and the same is not paid within ten days after Borrower receives notice
thereof, provided that none of the foregoing shall 

  
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constitute an Event of Default where such action or event is stayed or an adequate bond has been posted pending a good faith contest by Borrower (provided that no Credit Extensions will be made
during such cure period); 
 8.5 Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is
commenced by Borrower, or if an Insolvency Proceeding is commenced against Borrower and is not dismissed or stayed within 30 days (provided that no Credit Extensions will be made prior to the dismissal of such Insolvency Proceeding); 

8.6 Other Agreements. If there is a default or other failure to perform in any agreement to which Borrower is a party with
a third party or parties resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of $100,000 or that would reasonably be expected to have a Material Adverse
Effect; 
 8.7 Judgments. If a final, uninsured judgment or judgments for the payment of money in an amount,
individually or in the aggregate, of at least $100,000 shall be rendered against Borrower and shall remain unsatisfied and unstayed for a period of 10 days (provided that no Credit Extensions will be made prior to the satisfaction or stay of the
judgment); or 
 8.8 Misrepresentations. If any material misrepresentation or material misstatement exists now or
hereafter in any warranty or representation set forth herein or in any certificate delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter into this Agreement or any other Loan Document. 

 

	 	9.	BANK’S RIGHTS AND REMEDIES. 

 9.1 Rights and Remedies. Upon the occurrence and during the continuance of an Event of Default, Bank may, at its election, without notice of its election and without demand, do any one or
more of the following, all of which are authorized by Borrower: 
 (a) Declare all Obligations, whether evidenced by
this Agreement, by any of the other Loan Documents, or otherwise, immediately due and payable (provided that upon the occurrence of an Event of Default described in Section 8.5 (insolvency), all Obligations shall become immediately due and
payable without any action by Bank); 
 (b) Demand that Borrower (i) deposit cash with Bank in an amount equal to
the amount of any Letters of Credit remaining undrawn, as collateral security for the repayment of any future drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees scheduled to be paid or payable over the
remaining term of the Letters of Credit, and Borrower shall promptly deposit and pay such amounts; 
 (c) Cease
advancing money or extending credit to or for the benefit of Borrower under this Agreement or under any other agreement between Borrower and Bank; 
 (d) Make such payments and do such acts as Bank considers necessary or reasonable to protect its security interest in the Collateral. Borrower agrees to make the Collateral available to Bank as
Bank may designate. Borrower authorizes Bank to take and maintain possession of the Collateral, or any part of it, and to pay, purchase, contest, or compromise any encumbrance, charge, or lien which in Bank’s determination appears to be prior
or superior to its security interest and to pay all expenses incurred in connection therewith; 
 (e) Set off and apply
to the Obligations any and all (i) balances and deposits of Borrower held by Bank, including specifically and without limitation any balances and deposits held in the Cash Security Account, and (ii) indebtedness at any time owing to or for
the credit or the account of Borrower held by Bank; 

  
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 (f) Apply for the appointment of a receiver, trustee, liquidator or conservator of
the Collateral, without notice and without regard to the adequacy of the security for the Obligations and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of the Obligations; and 

(g) Any deficiency that exists after disposition of the Collateral as provided above will be paid immediately by Borrower.

 Bank may comply with any applicable state or federal law requirements in connection with a disposition of the Collateral and compliance will
not be considered adversely to affect the commercial reasonableness of any sale of the Collateral. 
 9.2 No
Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the Obligations by collecting them from any other person liable for them and Bank may release, modify or waive any collateral provided by any other Person to secure any of
the Obligations, all without affecting Bank’s rights against Borrower. Borrower waives any right it may have to require Bank to pursue any other Person for any of the Obligations. 

9.3 Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements
shall be cumulative. Bank shall have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event
of Default on Borrower’s part shall be deemed a continuing waiver. No delay by Bank shall constitute a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a written document signed on behalf of Bank and
then shall be effective only in the specific instance and for the specific purpose for which it was given. Borrower expressly agrees that this Section 9.7 may not be waived or modified by Bank by course of performance, conduct, estoppel or
otherwise. 
 9.4 Demand; Protest. Except as otherwise provided in this Agreement, Borrower waives demand,
protest, notice of protest, notice of default or dishonor, notice of payment and nonpayment and any other notices relating to the Obligations. 
  

	 	10.	NOTICES. 

 Unless
otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement or any other agreement entered into in connection herewith shall be in writing and (except for financial statements and other informational
documents which may be sent by first-class mail, postage prepaid) shall be personally delivered or sent by a recognized overnight delivery service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Borrower or to
Bank, as the case may be, at its addresses set forth below: 
  

			
	If to Borrower:	  	LIGAND PHARMACEUTICALS, INC.
		  	11085 North Torrey Pines, Suite 300
		  	La Jolla, CA 92037
		  	Attn: General Counsel
		  	FAX: (858) 550-7272
		
	If to Bank:	  	Square 1 Bank
		  	406 Blackwell Street, Suite 240
		  	Durham, North Carolina 27701
		  	Attn: Loan Operations Manager
		  	FAX: (919) 314-3080
		
	with a copy to:	  	Square 1 Bank
		  	12481 High Bluff Drive, Suite 350
		  	San Diego, CA 92130
		  	Attn: Scott Foote
		  	FAX: (858) 436-3501

  
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 The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other. 
  

	 	11.	CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER. 

 This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of North Carolina, without regard to principles of conflicts of law. Jurisdiction shall lie in the
State of North Carolina. All disputes, controversies, claims, actions and similar proceedings arising with respect to Borrower’s account or any related agreement or transaction shall be brought in the General Court of Justice of North Carolina
sitting in Durham County, North Carolina or the United States District Court for the Middle District of North Carolina except as provided below with respect to arbitration of such matters. BANK AND BORROWER EACH ACKNOWLEDGE THAT THE RIGHT TO TRIAL
BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH OF THEM, AFTER CONSULTING OR HAVING HAD THE OPPORTUNITY TO CONSULT, WITH COUNSEL OF THEIR CHOICE, KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES ANY RIGHT ANY OF THEM MAY HAVE TO A
TRIAL BY JURY IN ANY LITIGATION BASED UPON OR ARISING OUT OF THIS AGREEMENT OR ANY RELATED INSTRUMENT OR LOAN DOCUMENT OR ANY OF THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT OR ANY COURSE OF CONDUCT, DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN),
OR ACTION OF ANY OF THEM. THESE PROVISIONS SHALL NOT BE DEEMED TO HAVE BEEN MODIFIED IN ANY RESPECT OR RELINQUISHED BY BANK OR BORROWER, EXCEPT BY A WRITTEN INSTRUMENT EXECUTED BY EACH OF THEM. If the jury waiver set forth in this Section 11 is
not enforceable, then any dispute, controversy, claim, action or similar proceeding arising out of or relating to this Agreement, the Loan Documents or any of the transactions contemplated therein shall be settled by final and binding arbitration
held in Durham County, North Carolina in accordance with the then current Commercial Arbitration Rules of the American Arbitration Association by one arbitrator appointed in accordance with those rules. The arbitrator shall apply North Carolina law
to the resolution of any dispute, without reference to rules of conflicts of law or rules of statutory arbitration. Judgment upon any award resulting from arbitration may be entered into and enforced by any state or federal court having jurisdiction
thereof. Notwithstanding the foregoing, the parties may apply to any court of competent jurisdiction for preliminary or interim equitable relief, or to compel arbitration in accordance with this Section. The costs and expenses of the arbitration,
including without limitation, the arbitrator’s fees and expert witness fees, and reasonable attorneys’ fees, incurred by the parties to the arbitration may be awarded to the prevailing party, in the discretion of the arbitrator, or may be
apportioned between the parties in any manner deemed appropriate by the arbitrator. Unless and until the arbitrator decides that one party is to pay for all (or a share) of such costs and expenses, both parties shall share equally in the payment of
the arbitrator’s fees as and when billed by the arbitrator. 
  

	 	12.	GENERAL PROVISIONS. 

12.1 Successors and Assigns. This Agreement shall bind and inure to the benefit of the respective successors and permitted
assigns of each of the parties and shall bind all persons who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor any rights hereunder may be assigned by Borrower without Bank’s prior written consent,
which consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without the consent of or notice to Borrower to sell, assign, transfer, negotiate, or grant participation in all or any part of, or any interest in,
Bank’s obligations, rights and benefits hereunder. 
 12.2 Indemnification. Borrower shall defend, indemnify
and hold harmless Bank and its officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities claimed or asserted by any other party in connection with the transactions contemplated by this Agreement; and
(b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank, its officers, employees and agents as a result of or in any way arising out of, following, or consequential to transactions between Bank and Borrower whether under
this Agreement, or otherwise (including without limitation reasonable attorneys fees and expenses), except for losses caused by Bank’s gross negligence or willful misconduct. 

12.3 Time of Essence. Time is of the essence for the performance of all obligations set forth in this Agreement.

  
 9 

 12.4 Severability of Provisions. Each provision of this Agreement shall be
severable from every other provision of this Agreement for the purpose of determining the legal enforceability of any specific provision. 
 12.5 Amendments in Writing, Integration. All amendments to or terminations of this Agreement or the other Loan Documents must be in writing. All prior agreements, understandings,
representations, warranties, and negotiations between the parties hereto with respect to the subject matter of this Agreement and the other Loan Documents, if any, are merged into this Agreement and the Loan Documents. 

12.6 Counterparts. This Agreement may be executed in any number of counterparts and by different parties on separate
counterparts, each of which, when executed and delivered, shall be deemed to be an original, and all of which, when taken together, shall constitute but one and the same Agreement. Executed copies of the signature pages of this Agreement sent by
facsimile or transmitted electronically in Portable Document Format (“PDF”), or any similar format, shall be treated as originals, fully binding and with full legal force and effect, and the parties waive any rights they may have to object
to such treatment. 
 12.7 Survival. All covenants, representations and warranties made in this Agreement shall
continue in full force and effect so long as any Obligations remain outstanding or Bank has any obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify Bank with respect to the expenses, damages, losses, costs
and liabilities described in Section 12.2 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Bank have run. 

12.8 Confidentiality. In handling any confidential information, Bank and all employees and agents of Bank shall exercise
the same degree of care that Bank exercises with respect to its own proprietary information of the same types to maintain the confidentiality of any non-public information thereby received or received pursuant to this Agreement except that
disclosure of such information may be made (i) to the subsidiaries or Affiliates of Bank or Borrower in connection with their present or prospective business relations with Borrower, (ii) to prospective transferees or purchasers of any
interest in the Credit Extensions, provided that they have entered into a comparable confidentiality agreement in favor of Borrower and have delivered a copy to Borrower, (iii) as required by law, regulations, rule or order, subpoena, judicial
order or similar order, (iv) as may be required in connection with the examination, audit or similar investigation of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder. Confidential information
hereunder shall not include information that either: (a) is in the public domain or in the knowledge or possession of Bank when disclosed to Bank, or becomes part of the public domain after disclosure to Bank through no fault of Bank; or
(b) is disclosed to Bank by a third party, provided Bank does not have actual knowledge that such third party is prohibited from disclosing such information. 
 [Balance of Page Intentionally Left Blank] 

  
 10 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
date first above written. 
  

			
	 LIGAND PHARMACEUTICALS,
 INCORPORATED

		
	By:	 	 /s/ John Sharp

		
	Title:	 	 Vice President, Finance and
Chief Financial Officer

	
	SQUARE 1 BANK
		
	By:	 	 /s/ Evan Travis

		
	Title:	 	 Venture Banking Officer, Life Sciences

[Signature Page to Loan and Security Agreement] 

  
 11 

 EXHIBIT A 
 DEFINITIONS 
 “Advance” or “Advances” means a cash advance or cash advances
under the Revolving Line. 
 “Affiliate” means, with respect to any Person, any Person that owns or controls directly or indirectly
such Person, any Person that controls or is controlled by or is under common control with such Person, and each of such Person’s senior executive officers, directors, and general partners. 

“Authorized Officer” means someone designated as such in the corporate resolution provided by Borrower to Bank in which this Agreement and the
transactions contemplated hereunder are authorized by Borrower’s board of directors. If Borrower provides subsequent corporate resolutions to Bank after the Closing Date, the individual(s) designated as “Authorized Officer(s)” in the
most-recently provided resolution shall be the only “Authorized Officers” for purposes of this Agreement. 
 “Bank Expenses”
means all reasonable costs or expenses (including reasonable attorneys’ fees and expenses) incurred in connection with the preparation, negotiation, administration, and enforcement of the Loan Documents; and Bank’s reasonable
attorneys’ fees and expenses (whether generated in-house or by outside counsel) incurred in amending, enforcing or defending the Loan Documents (including fees and expenses of appeal), incurred before, during and after an Insolvency Proceeding,
whether or not suit is brought. 
 “Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in the
State of North Carolina are authorized or required to close. 
 “Cash” means unrestricted cash and cash equivalents. 

“Cash Security Account” means segregated Certificate of Deposit, account No. 60100378, held at Bank as collateral for Borrower’s
Obligations, in a minimum amount of $5,000,000. 
 “Change in Control” shall mean a transaction other than a bona fide equity
financing or series of financings on terms and from investors reasonably acceptable to Bank in which any “person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes
the “beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly or indirectly, of a sufficient number of shares of all classes of stock then outstanding of Borrower ordinarily entitled to vote in the
election of directors, empowering such “person” or “group” to elect a majority of the Board of Directors of Borrower, who did not have such power before such transaction; provided that any such transaction occurring solely in the
secondary securities markets and without any action by or on behalf of the Borrower shall not be considered a Change in Control. 

“Closing Date” means the date of this Agreement. 
 “Code” means the North Carolina Uniform Commercial Code as amended or supplemented from time to time. 
 “Collateral” means Cash in the amount of at least $5,000,000 held in the Cash Security Account and pledged to Bank as security for the Obligations. 

“Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or otherwise, of that Person with respect
to (i) any indebtedness, lease, dividend, letter of credit or other obligation of another, including, without limitation, any such obligation directly or indirectly guaranteed, endorsed, co-made or discounted or sold with recourse by that
Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit, corporate credit cards or merchant services issued for the account of that Person; and
(iii) all obligations arising under any interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in
interest rates, currency exchange rates or commodity prices; provided, however, that the term “Contingent Obligation” shall not include endorsements for collection or deposit in the ordinary course of business. The amount of any Contingent
Obligation shall be deemed to be an amount equal to the 

  
 1 

 
stated or determined amount of the primary obligation in respect of which such Contingent Obligation is made or, if not stated or determinable, the maximum reasonably anticipated liability in
respect thereof as determined by such Person in good faith; provided, however, that such amount shall not in any event exceed the maximum amount of the obligations under the guarantee or other support arrangement. 

“Credit Extension” means each Advance or any other extension of credit by Bank, to or for the benefit of Borrower hereunder. 

“ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the regulations thereunder. 

“Event of Default” has the meaning assigned in Article 8. 
 “GAAP” means generally accepted accounting principles, consistently applied, as in effect from time to time in the United States. 
 “Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of property or services, including without limitation reimbursement and other obligations with
respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or similar instruments, (c) all capital lease obligations, and (d) all Contingent Obligations, including but not limited to any
sublimit contained herein. 
 “Insolvency Proceeding” means any proceeding commenced by or against any Person or entity under any
provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy or insolvency law, including assignments for the benefit of creditors, formal or informal moratoria, compositions, extension generally with its creditors, or
proceedings seeking reorganization, arrangement, or other relief. 
 “IRC” means the Internal Revenue Code of 1986, as amended, and
the regulations thereunder. 
 “Letter of Credit” means a commercial or standby letter of credit or similar undertaking issued by Bank
at Borrower’s request. 
 “Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower, and any
other document, instrument or agreement entered into in connection with this Agreement, all as amended or extended from time to time. 

“Material Adverse Effect” means a material adverse effect on (i) the operations, business or financial condition of Borrower and its
Subsidiaries taken as a whole, (ii) the ability of Borrower to repay the Obligations or otherwise perform its obligations under the Loan Documents, or (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s
security interest in the Collateral. 
 “Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to
Bank by Borrower pursuant to this Agreement or any other agreement, whether absolute or contingent, due or to become due, now existing or hereafter arising, including any interest that accrues after the commencement of an Insolvency Proceeding and
including any debt, liability, or obligation owing from Borrower to others that Bank may have obtained by assignment or otherwise. 

“Periodic Payments” means all installments or similar recurring payments that Borrower may now or hereafter become obligated to pay to Bank
pursuant to the terms and provisions of any instrument, or agreement now or hereafter in existence between Borrower and Bank. 

“Person” means any individual, sole proprietorship, partnership, limited liability company, joint venture, trust, unincorporated organization,
association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or governmental agency. 

  
 2 

 “Prime Rate” means the variable rate of interest, per annum, most recently announced by Bank, as
its “prime rate,” whether or not such announced rate is the lowest rate available from Bank. 
 “Responsible Officer” means
each of the Chief Executive Officer, the Chief Operating Officer, the Chief Financial Officer and the Controller of Borrower, as well as any other officer or employee identified as an Authorized Officer in the corporate resolution delivered by
Borrower to Bank in connection with this Agreement. 
 “Revolving Line” means 1 or more Credit Extensions in an aggregate amount of up
to $5,000,000. 
 “Revolving Maturity Date” means March 29, 2012. 
 “Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any. 
 “Subsidiary” means any corporation, partnership or limited liability company or joint venture in which (i) any general partnership interest or (ii) more than 50% of the stock, limited
liability company interest or joint venture of which by the terms thereof ordinary voting power to elect the Board of Directors, managers or trustees of the entity, at the time as of which any determination is being made, is owned by Borrower,
either directly or through an Affiliate. 

  
 3 

 EXHIBIT B 
 LOAN ADVANCE / PAYDOWN REQUEST FORM 
 [Please refer to New Borrower Kit]

 EXHIBIT C 
 COMPLIANCE CERTIFICATE 
 [Please refer to New Borrower Kit]

  
 1 

 SCHEDULE OF EXCEPTIONS 
 Prior Names (Section 5.5) – None. 
 Litigation (Section 5.6) – None.

  
 2 

 CORPORATE RESOLUTION 
 The undersigned duly elected and qualified Secretary of Ligand Pharmaceuticals, Incorporated (the “Company”) do hereby certify that the following is a true and correct copy of certain
resolutions adopted at a meeting of the Company’s Board of Directors held on March 6, 2003 in accordance with applicable law and the Company’s bylaws, and that such resolutions are now unmodified and in full force and effect:

 BE IT RESOLVED, that: 

1. Any one (1) of the following, duly elected officers of the Company (each, an “Authorized Officer”) whose genuine original
signature appears next to his or her name is authorized to act for, on behalf of, and in the name of the Company in connection with the resolutions below: 
  

					
	 Title
	  	 Name
	  	 Authorized Signature

			
	Vice President, General Counsel & Secretary	  	Charles S. Berkman	  	  

			
	Vice President, Finance and Chief Financial Officer	  	John P. Sharp	  	  

			
	  
	  	  
	  	  

			
	  
	  	  
	  	  

 2. The Authorized Officers are hereby empowered to execute a Square 1 Bank (“Bank”) Signature Card and/or Funds Transfer Agreement, and any other agreements or documents required by Bank
in connection therewith, on behalf of the Company upon the terms and conditions set out in the Signature Card and/or Funds Transfer Agreement and other Agreements and, from time to time, to make changes to the Signature Card, Funds Transfer
Agreement and/or other Agreements or any Exhibit thereto, including without limitation the list of Authorized Representatives; 
 3. Any
Authorized Officer may borrow money from time to time from Bank, and may negotiate and procure loans, letters of credit, foreign exchange contracts and other financial accommodations from Bank, including without limitation, that certain Loan and
Security Agreement dated as of March 31, 2011, and also to execute and deliver to Bank one or more renewals, extensions, or modifications thereof; 
 4. Give security for any liabilities of the Company to Bank by grant, security interest, assignment, lien, deed of trust or mortgage upon any real or personal property, tangible or intangible of
the Company; 
 5. Purchase, sell, exchange, assign, endorse for transfer and/or deliver certificates and/or instruments representing
stocks, bonds, evidences of Indebtedness or other securities owned by the Company, whether or not registered in the name of the Company; 

6. Discount with the Bank, commercial or other business paper belonging to the Company made or drawn by or upon third parties, without limit as to
amount; 
 7. The Bank is authorized and directed to pay the proceeds of any such loans or discounts as directed by the persons so
authorized to sign; and 
 8. Execute and deliver in form and content as may be required by the Bank any and all notes, evidences of
indebtedness, applications for letters of credit, guaranties, subordination agreements, loan and security agreements, financing statements, assignments, liens, deeds of trust, mortgages, trust receipts and other agreements, instruments or documents
to carry out the purposes of these Resolutions, any or all of which may relate to all or to substantially all of the Company’s property and assets; 
 The Authorized Officers may designate additional or alternate individuals as being authorized to request loan advances, to do and perform such other acts and things, to pay any and all fees and costs, and
to execute and deliver such other documents and agreements as he or she may in his or her discretion deem reasonably necessary or proper in order to carry into effect the provisions of these Resolutions. 

  
 1 

 Any and all acts authorized pursuant to these resolutions and performed prior to the passage of these
resolutions are hereby ratified and approved, and the authority conferred herein may be exercised singly by any such officer, and these resolutions shall continue in full force and effect until written notice of modification or revocation is
received and accepted Bank (such notice to have no effect on any action previously taken by the Bank in reliance on these Resolutions). Bank may rely upon any form of notice, which it in good faith believes to be genuine or what it purports to be.

 The Resolutions are in full force and effect as of the date of this Certificate and are intended to replace, as of this date, any Resolutions
previously given by the Company to Bank in connection with the matters described herein; these Resolutions and any borrowings or financial accommodations under these Resolutions have been properly noted in the corporate books and records, and have
not been rescinded, revoked or modified; neither the foregoing Resolutions nor any actions to be taken pursuant to them are or will be in contravention of any provision of the articles of incorporation or bylaws of the Company or of any agreement,
indenture or other instrument to which the Company is a party or by which it is bound; and to the extent the articles of incorporation or bylaws of the Company or any agreement, indenture or other instrument to which the Company is a party or by
which it is bound require the vote or consent of shareholders of the Company to authorize any act, matter or thing described in the foregoing Resolutions, such vote or consent has been obtained. 

In Witness Whereof, I have affixed my name as Secretary and have caused the corporate seal (where available) of said Company to be affixed on
March 30, 2011. 
  

	
	  

	Secretary*

  

	*	If the certifying officer is designated as the only signer in these resolutions then another corporate officer must also sign. 

 

	
	  

  
 2 

 USA PATRIOT ACT 

NOTICE 

OF 

CUSTOMER IDENTIFICATION 
 IMPORTANT INFORMATION ABOUT PROCEDURES FOR OPENING A NEW ACCOUNT 
 To help the
government fight the funding of terrorism and money laundering activities, Federal law requires all financial institutions to obtain, verify, and record information that identifies each person who opens an account. 

WHAT THIS MEANS FOR YOU: when you open an account, we will ask your name, address, date of birth, and other information that will allow us to identify
you. We may also ask to see your driver’s license or other identifying documents. 

  
 1 

					
	SQUARE 1 BANK	 		 	
	AUTOMATIC DEBIT AUTHORIZATION
	Member FDIC	 		 	

  

					
	To: Square 1 Bank	 		 	
			
	 Re: Loan #
                                         
   
	 		 	

 You are hereby authorized and instructed to charge account No.
                         in the name of LIGAND PHARMACEUTICALS, INCORPORATED. 

for facility fees, principal, interest and other payments due on above referenced loan as set forth below and credit the loan referenced above.

 x Debit the Facility Fee as it becomes due according to the terms of the Loan
and Security Agreement and any renewals or amendments thereof. 
 x Debit each
interest payment as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof. 
 x Debit each principal payment as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof.

 x Debit each payment for Bank Expenses as it becomes due according to the
terms of the Loan and Security Agreement and any renewals or amendments thereof. 
 This Authorization is to
remain in full force and effect until revoked in writing. 
  

					
	Borrower Signature	 		 	Date
			
	  
	 		 	  

			
	  
	 		 	  

			
	  
	 		 	  

  
 2 

			
	Phone:                     	 	SQUARE 1 BANK
	Fax                          	 	CLIENT AUTHORIZATION

  

General Authorization 
 I hereby
authorize Square 1 Bank to use my company name, logo, and information relating to our banking relationship in its marketing and advertising campaigns which is intended for Square 1 Bank’s customers, prospects and shareholders. 

Square 1 Bank will forward any advertising or article including client for prior review and approval. 

 

					
			
	  
 Signature
	 		 	
			
	  
 Printed Name
                        Title
	 		 	
			
	  
 Company
	 		 	
			
	  
 Mailing Address
	 		 	
			
	  
 City, State, Zip
Code
	 		 	
			
	  
 Phone Number
	 		 	
			
	  
 Fax Number
	 		 	
			
	  
 E-Mail
	 		 	
			
	March     , 2011	 		 	
	Date	 		 	

  
  

  
 3Second Amendment to Credit and Security Agreement and Other Loan Documents

 Exhibit 10.1 
 SECOND AMENDMENT TO CREDIT AND SECURITY AGREEMENT 

AND OTHER LOAN DOCUMENTS 
 THIS SECOND AMENDMENT TO CREDIT AND SECURITY AGREEMENT AND OTHER LOAN DOCUMENTS (this “Amendment”) is made and entered into as of March 31, 2011, by and between UNILENS
CORP. USA, a Delaware corporation and UNILENS VISION SCIENCES INC., a Delaware corporation (together, “Borrower”) and REGIONS BANK, an Alabama corporation (“Lender”). 

RECITALS 

A. Pursuant to that certain Credit and Security Agreement dated as of November 9, 2009, as amended by that certain Joinder Agreement
and First Amendment to Credit and Security Agreement and Other Loan Documents dated as of August 12, 2010 (as the same may be amended, supplemented, modified and restated from time to time, collectively, the “Loan Agreement”),
Lender has agreed to make a Term Loan and Revolving Loan (as defined in the Loan Agreement) to Borrower. 
 B. Borrower has
requested that Lender amend the terms of the Term Loan and the Loan Agreement, and Lender has agreed to do so upon the terms and subject to the conditions set forth herein and in the Loan Agreement provided (among other things) that the parties
hereto execute and deliver this Amendment and otherwise comply with the agreements set forth herein and in the Loan Agreement. 

C. In furtherance of the foregoing, the parties hereto desire to enter into this Amendment to amend the Loan Agreement and the other loan
documents executed in connection therewith (collectively, “Loan Documents”) in certain respects as provided herein. 
 AGREEMENTS 
 NOW, THEREFORE, in consideration of the foregoing, the
terms and conditions, premises and other mutual covenants set forth in this Amendment, and other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, Lender and Borrower hereby agree as follows: 

Section 1. Definitions. Unless otherwise defined herein, all capitalized terms used and not defined herein shall have
the meanings assigned to such terms in the Loan Agreement. 
 Section 2. Modification of Loan Agreement. The
Loan Agreement is hereby modified as follows: 
 (a) The following terms are added to Section 1.1 of the Loan Agreement:

 “Dividends: actual dividends declared or paid following the end of a quarter, as reported in the financial
statements for such quarter, multiplied times four (4).” 
 “EBIDAR: Borrower’s earnings before interest
expense, depreciation, amortization expense and rent/lease expense.” 

  
 5 

 “Excess EBIDAR: the amount of EBIDAR (as defined above) for the quarter being
tested remaining after the required Fixed Charges in the Fixed Charge Coverage Ratio have been covered 1.20 to 1.00 for the quarter being tested.” 
 “Fixed Charges: current maturities of long-term debt plus scheduled principal payments on capital lease obligations, interest expense, rent expense, maintenance capital expenditures
(calculated at twenty percent (20%) of depreciation expense), and Dividends.” 
 (b) The definition of “Fixed
Charge Coverage Ratio” in Section 1.1 of the Loan Agreement is hereby deleted in its entirety and replaced with the following: 
 “Fixed Charge Coverage Ratio: EBIDAR divided by Fixed Charges.” 

(c) Section 9.2(c) of the Loan Agreement is hereby deleted in its entirety and replaced with the following: 

“(c) declare or pay, or cause or permit any of its Subsidiaries to declare or pay, dividends upon any of Borrower’s or a
Subsidiary’s Stock or make, or cause or permit any of its Subsidiaries to make, any distributions of Borrower’s or a Subsidiary’s property or assets or make, or cause or permit any of its Subsidiaries to make, any loans, advances or
extensions of credit, except on ordinary credit terms in connection with sales of Inventory in the ordinary course of business, to any Person, including, without limitation, any of Borrower’s or a Subsidiary’s Affiliates, officers or
employees, except dividends, distributions, loans, advances or extensions of credit from a Subsidiary to Borrower; provided that Borrower may issue cash dividends upon its Stock to Guarantor to pay a $0.045 per share cash dividend to the holders of
its common shares per quarter without the prior written consent of Lender.” 
 Section 3. Representations and
Warranties.  
 (a) Notwithstanding any other provision of this Amendment, each Borrower hereby (a) confirms and
makes all of the representations and warranties set forth in the Loan Agreement and other Loan Documents with respect to Borrower and confirms that they are true and correct in all material respects, (b) represents and warrants that they are
Affiliates of each other, and (c) specifically represents and warrants to Lender that it has good and marketable title to all of its respective Collateral (if any), free and clear of any Lien or security interest in favor of any other Person.

 (b) Each Borrower hereby represents and warrants as of the date of this Amendment as follows: (i) it is duly
incorporated or organized, validly existing and in good standing under the laws of its jurisdiction of organization; (ii) the execution, delivery and performance by it of this Amendment are within its powers, have been duly authorized, and do
not contravene (A) its articles of incorporation, bylaws, or other organizational documents, or (B) any applicable law; (iii) no consent, license, permit, approval or authorization of, or registration, filing or declaration with any
Governmental Authority or other Person (except for those that have already been obtained), is required in connection with the execution, delivery, performance, validity or enforceability of this Amendment, by or against it; (iv) this Amendment
has been duly executed and delivered by it; (v) this Amendment constitutes its legal, valid and binding obligations enforceable against it in accordance with its terms, except as enforceability may be limited by applicable bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting the enforcement of creditors’ rights generally or by general principles of equity; and (vi) it is not in default under the Loan Agreement and no Event of Default exists, has
occurred or is continuing. 

  
 6 

 Section 4. Reference to the Effect. Upon the effectiveness of this
Amendment, each reference in the Loan Agreement to “this Agreement,” “hereunder,” “hereof,” “herein” or words of similar import shall mean and be a reference to the Loan Agreement as amended by this Amendment.
Except as specifically amended hereby, the Loan Agreement and all other Loan Documents shall remain in full force and effect and the terms thereof are expressly incorporated herein and are ratified and confirmed in all respects. This Amendment is
not intended to be or to create, nor shall it be construed as or constitute, a novation or an accord and satisfaction but shall constitute an amendment of the Loan Agreement and the other Loan Documents. The parties hereto agree to be bound by the
terms and conditions of the Loan Agreement and the other Loan Documents as amended by this Amendment as though such terms and conditions were set forth herein in full. The execution, delivery and effectiveness of this Amendment shall not, except as
expressly provided in this Amendment, operate as a waiver of any right, power or remedy of Lender, nor constitute a waiver of any provision of the Loan Agreement or any other Loan Document or any other documents, instruments and agreements executed
or delivered in connection therewith or of any default or Event of Default under any of the foregoing whether arising before or after the date hereof or as a result of performance hereunder. 

Section 5. Governing Law and Jury Trial. THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES UNDER THIS AMENDMENT
SHALL BE GOVERNED BY AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH THE CHOICE OF LAW PROVISIONS SET FORTH IN THE LOAN AGREEMENT AND SHALL BE SUBJECT TO THE WAIVER OF JURY TRIAL PROVISION OF THE LOAN AGREEMENT. 

Section 6. Headings and Counterparts. The captions in this Amendment are intended for convenience and reference only and do
not constitute and shall not be interpreted as part of this Amendment and shall not affect the meaning or interpretation of this Amendment. This Amendment may be executed in one or more counterparts, all of which taken together shall constitute but
one and the same instrument. This Amendment may be executed by facsimile transmission, which facsimile signatures shall be considered original executed counterparts for all purposes, and each party to this Amendment agrees that it will be bound by
its own facsimile signature and that it accepts the facsimile signature of each other party to this Amendment. 

Section 7. Amendments. This Amendment may not be changed, modified, amended, restated, waived, supplemented, discharged,
canceled or terminated orally or by any course of dealing or in any other manner other than by the written agreement of Lender and Borrower. This Amendment shall be considered part of the Loan Agreement and the other Loan Documents for all purposes.

 Section 8. Entire Agreement. This Amendment, the Loan Agreement, and the other Loan Documents constitute the
entire agreement between the parties with respect to the subject matter hereof and thereof and supersedes all prior agreements and understandings, if any, relating to the subject matter hereof and thereof and may not be contradicted by evidence of
prior, contemporaneous or subsequent oral agreements between the parties. There are no unwritten oral agreements between the parties. 
 Section 9. Miscellaneous. Whenever the context and construction so require, all words used in the singular number herein shall be deemed to have been used in the plural, and vice versa, and
the masculine gender shall include the feminine and neuter and the neuter shall include the masculine and feminine. This Amendment shall inure to the benefit of Lender, all future holders of any note, any of the Obligations or any of the Collateral
and all of Lender’s transferees, and each of their respective successors and permitted assigns. 

  
 7 

 
Borrower may not assign, delegate or transfer this Amendment or any of its rights or obligations under this Amendment without the prior written consent of Lender. No rights are intended to be
created under this Amendment for the benefit of any third party donee, creditor or incidental beneficiary of Borrower or any guarantor. Nothing contained in this Amendment shall be construed as a delegation to Lender of any Borrower’s duty of
performance, including, without limitation, any duties under any account or contract in which Lender has a security interest or Lien. This Amendment shall be binding upon Borrower and their respective successors and assigns. 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
 8 

 IN WITNESS WHEREOF, the parties have caused this Second Amendment to Credit and
Security Agreement and Other Loan Documents to be executed by their respective officers thereunto duly authorized as of the date first written above. 
  

					
	LENDER:	 	 REGIONS BANK, an Alabama banking
 corporation

			
		 	By:	 	 /s/ David M. Risen

		 	Name:	 	David M. Risen
		 	Title:	 	Assistant Vice President
		
	BORROWER:	 	 UNILENS CORP. USA, a Delaware
 corporation

			
		 	By:	 	 /s/ Michael J. Pecora

		 		 	Michael J. Pecora
		 		 	President
		
		 	 UNILENS VISION SCIENCES INC., a
 Delaware corporation

			
		 	By:	 	 /s/ Joan L. Yori

		 		 	 Joan L. Yori
 Vice
President

  
 9

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