Document:

EX-10.1

 Exhibit 10.1 

TRIPADVISOR, INC. AMENDED AND RESTATED OPTION AGREEMENT 

(Domestic) 

THIS AMENDED AND RESTATED OPTION AGREEMENT (this “Agreement”), effective June 5, 2017 (the
“Effective Date”), between TripAdvisor, Inc., a Delaware corporation (the “Company”), and Stephen Kaufer (the “Eligible Individual”), describes the terms of an award of an
Option previously granted to the Eligible Individual by the Company.  
 RECITALS 

A. The Company and the Eligible Individual are parties to an Option Agreement dated as of August 28, 2013 (the
“Grant Date”) with respect to the option to purchase 1,100,000 shares of Common Stock (the “Option”) granted by the Company to the Eligible Individual (the “Original
Agreement”).  
 B. The Company and the Eligible Individual have entered into this Agreement for the purpose of
amending and restating the terms of the Original Agreement and the terms of the Option. 
 C. All capitalized terms used
herein, to the extent not defined, shall have the meanings ascribed to them in the Company’s Amended and Restated 2011 Stock and Annual Incentive Plan (as amended from time to time, the “Plan”). Reference is made to the
“Grant Details” that can be found on the equity plan website of the current professional selected by the Company to administer the Plan (the “Plan Administrator”), currently located at www.netbenefits.fidelity.com
(or any successor equity administration system selected by the Company to manage the Plan from time to time).  
 AGREEMENT

 NOW, THEREFORE, in consideration of the foregoing and other good and valuable consideration, the receipt and sufficiency of which is
hereby acknowledged, the parties agree as follows: 
  

	1.	Award of Option 

 (a) Subject to the terms and conditions of this Agreement and
the Plan and the Grant Details, the Company hereby grants the Option to the Eligible Individual. Reference is made to the “Grant Details” that can be found on the equity plan website of the current professional selected by the Company to
administer the Plan (the “Plan Administrator”), currently located at www.netbenefits.fidelity.com (or any successor equity administration system selected by the Company to manage the Plan from time to time). Your Grant
Details, which sets forth the number of options, the grant price which is the per Share exercise price of the Option, the Grant Date of the Option, and the vesting schedule of the Option (among other information), is hereby incorporated by reference
into, and shall be read as part and parcel of, this Agreement. 
 (b) The Option shall be a Nonqualified Option. Unless earlier terminated
pursuant to the terms of this Agreement or the Plan, the Option shall expire on the ten-year anniversary of the Grant Date. 

	2.	Vesting 

 Subject to (a) the terms and conditions of this Agreement, the
Grant Details and the Plan, and (b) the Eligible Individual’s continuous employment by the Company or one of its Subsidiaries or Affiliates, the Option shall vest and become exercisable on each of the vesting dates detailed in the
Grant Details (such period between the date of issuance and each vesting date shall be referred to as the “Vesting Period”). In the event a Termination of Employment of the Eligible Individual occurs prior to the expiration
of the Vesting Period for any reason (or for no reason), except as otherwise provided in the Employment Agreement between the Company and Eligible Individual, all remaining unvested Option shall be forfeited by the Eligible Individual and canceled
in their entirety effective immediately as of the date of such Termination of Employment. 
  

	3.	Exercise of Option 

 (a) This Option is exercisable by delivery of
an exercise notice which shall state the election to exercise the Option, the number of Shares in respect of which the Option is being exercised and such other representations and agreements as may be required by the Company or the Plan
Administrator (the “Exercise Notice”). The Exercise Notice shall be in the form and delivered in the manner prescribed by the Plan Administrator.  

(b) The Exercise Notice shall be accompanied by payment of the aggregate exercise price as to all Shares in respect of which the Option is
being exercised. Payment of the aggregate exercise price shall be by any of the following, or a combination thereof, at the election of the Eligible Individual: (i) cash, (ii) check, (iii) a “broker-assisted” or
“same-day sale”; or (iv) other method authorized by the Company and/or the Plan Administrator. 
 (c) No Shares shall be
issued pursuant to the exercise of the Option unless such issuance and exercise complies with all relevant provisions of law and the requirements of any stock exchange or quotation service upon which the Shares are then listed. 

 

	4.	Termination of Employment by the Company for Cause  

 (a) Notwithstanding
the provisions above, in the event the Eligible Individual incurs a Termination of Employment for Cause or the Eligible Individual voluntarily incurs a Termination of Employment within two years after any event or circumstance that would have been
grounds for a Termination of Employment for Cause, the Eligible Individual agrees that the Option (whether or not vested) shall be forfeited and cancelled in their entirety upon such Termination of Employment. In such event, the Company may cause
the Eligible Individual, immediately upon notice from the Company, to either (i) return the Option and/or Shares issued upon exercise of the Option that vested during the two-year period after the events or circumstances giving rise to or
constituting grounds for such Termination of Employment for Cause or (ii) pay to the Company an amount equal to the aggregate amount, if any, that the Eligible Individual had previously realized in respect of any and all Shares issued upon
exercise of the Option that were exercised during the two-year period after the events or circumstances giving rise to or constituting grounds for such Termination of Employment for Cause (i.e. the value of the Shares issued upon exercise of the
Option and sold), in each case including any dividend equivalents or other distributions received in respect of any such Option. 

  
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 (b) For purpose of this Agreement, employment with the Company shall include employment with the
Company’s Subsidiaries or Affiliates. The Committee shall have the exclusive discretion to determine whether there has been any Termination of Employment and whether there existed Cause. 

 

	5.	Non-Transferability of the Option 

 During the Vesting Period and until such time
as the Option is ultimately exercised as provided herein or on the website of the Plan Administrator, the Option shall not be transferable by the Eligible Individual by means of sale, assignment, exchange, encumbrance, pledge, hedge or otherwise.

  

	6.	Rights as a Stockholder 

 Except as otherwise specifically provided in this
Agreement, during the Vesting Period the Eligible Individual shall not be entitled to any rights of a stockholder with respect to the Option. Notwithstanding the foregoing, if the Company declares and pays dividends on the Common Stock during the
Vesting Period, the Eligible Individual will be credited with additional amounts for each Option equal to the dividend that would have been paid with respect to such Option if it had been an actual share of Common Stock, which amount shall remain
subject to restrictions (and as determined by the Committee may be reinvested in options or may be held in kind as restricted property) and shall vest concurrently with the vesting of the Option upon which such dividend equivalent amounts were paid.
Notwithstanding the foregoing, dividends and distributions other than regular cash dividends, if any, may result in an adjustment pursuant to Section 7 below, rather than under this Section 6. 

 

	7.	Adjustment in the Event of Change in Stock; Change in Control 

 (a) In the event
of (i) a stock dividend, stock split, reverse stock split, share combination or recapitalization or similar event affecting the capital structure of the Company (each, a “Share Change”), or (ii) a merger,
consolidation, acquisition of property or shares, separation, spinoff, reorganization, stock rights offering, liquidation, Disaffiliation, payment of cash dividends other than an ordinary dividend or similar event affecting the Company or any of its
Subsidiaries (each, a “Corporate Transaction”), the Committee or the Board may in its discretion make such substitutions or adjustments as it deems appropriate and equitable to the number of options and the number and kind of shares of
Common Stock underlying the Option. 
 (b) In the case of Corporate Transactions, such adjustments may include, without limitation
(i) the cancellation of the Option in exchange for payments of cash, property or a combination thereof having an aggregate value equal to the value of such Option, as determined by the Committee or the Board in its sole discretion,
(ii) the substitution of other property (including, without limitation, cash or other securities of the Company and securities of entities other than the Company) for the shares of Common Stock underlying the Option and (iii) in connection
with any Disaffiliation, arranging for the assumption of the Option, or the 

  
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replacement of the Option with new awards based on other property or other securities (including, without limitation, other securities of the Company and securities of entities other than the
Company), by the affected Subsidiary or Affiliate or by the entity that controls such Subsidiary or Affiliate following such Disaffiliation (as well as any corresponding adjustments to any Option that remain based upon securities of the Company).

 (c) The determination of the Committee regarding any such adjustment will be final and conclusive and need not be the same for all
Participants. 
 (d) Unless otherwise determined by the Committee, in the event of a Change in Control, the provisions of Section 10 of
the Plan shall apply. 
  

	8.	Taxes, Fees and Withholding  

 (a) The Company agrees to pay any and all original
issue taxes and stock transfer taxes that may be imposed on the issuance of shares received by an Eligible Individual in connection with the Option, together with any and all other fees and expenses necessarily incurred by the Company in connection
therewith. 
 (b) Regardless of any action the Company, its Affiliate or Subsidiary takes with respect to any or all income tax, social
insurance, payroll tax, payment on account or other tax-related withholding (“Tax-Related Items”), the Eligible Individual acknowledges that the ultimate liability for all Tax-Related Items legally due by him or her is and remains the
Eligible Individual’s responsibility and that the Company and/or its Affiliate or Subsidiary (1) make no representations or undertakings regarding the treatment of any Tax-Related Items in connection with any aspect of the Award, including
the exercise of the Option and issuance of the Shares in connection therewith, the receipt of cash or any dividends or dividend equivalents; and (2) do not commit to structure the terms of the award or any aspect of the Option to reduce or
eliminate the Eligible Individual’s liability for Tax-Related Items. 
 (c) In the event that the Company, Subsidiary or Affiliate is
required to withhold any Tax-Related Items as a result of the award, vesting or exercise of the Option, or the receipt of cash or any dividends or dividend equivalents, the Eligible Individual shall pay or make adequate arrangements satisfactory to
the Company, Subsidiary or Affiliate to satisfy all withholding and payment on account of obligations of the Company, Subsidiary and/or Affiliate. The obligations of the Company under this Agreement shall be conditioned on compliance by the Eligible
Individual with this Section 8. In this regard, the Eligible Individual authorizes the Company and/or its Subsidiary or Affiliate to withhold all applicable Tax-Related Items legally payable by the Eligible Individual from his or her wages or
other cash compensation paid to the Eligible Individual by the Company and/or its Subsidiary or Affiliate. Alternatively, or in addition, if permissible under local law, the Company may withhold in Shares, provided that the Company only withholds
the amount of Shares necessary to satisfy the minimum withholding amount. Finally, the Eligible Individual will pay to the Company any amount of Tax-Related Items that the Company may be required to withhold as a result of the Eligible
Individual’s participation in the Plan or the Eligible Individual’s award that cannot be satisfied by the means previously described. The Company may refuse to deliver the Shares issuable upon exercise of the Option Award if the Eligible
Individual fails to comply with his or her obligations in connection with the Tax-Related Items as described in this Section. 

  
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 (d) In particular, the Eligible Individual understands and acknowledges that all income to which
the Eligible Individual is entitled under this Agreement is pre-tax and the Company or its Subsidiaries or Affiliates has the right to withhold and pay on behalf of the Eligible Individual any individual income tax in connection with such income in
accordance with applicable law. In the event the Company or its Subsidiaries or Affiliates is not required under applicable law to serve as the withholding agent to withhold and pay on behalf of the Eligible Individual such individual income tax,
the Eligible Individual shall have sole responsibility to make such payment, in which case the Eligible Individual shall provide, as requested by the Company or its Subsidiaries or Affiliates from time to time, relevant tax receipts to certify full
and prompt payment. The Eligible Individual agrees to indemnify the Company and/or its Subsidiaries or Affiliates for any liability which may arise as a result of his or her failure to pay any and all taxes associated with any income derived
pursuant to awards made under this Agreement. 
  

	9.	Other Restrictions 

 (a) The Restricted Stock Units shall be subject to the
requirement that, if at any time the Committee shall determine that (i) the listing, registration or qualification of the shares of Common Stock subject or related thereto upon any securities exchange or under any state or federal law, or
(ii) the consent or approval of any government regulatory body is required, then in any such event, the award of Restricted Stock Units shall not be effective unless such listing, registration, qualification, consent or approval shall have been
effected or obtained free of any conditions not acceptable to the Committee. 
 (b) The Eligible Individual acknowledges that the Eligible
Individual is subject to the Company’s policies regarding compliance with securities laws, including but not limited to its Insider Trading Policy (as in effect from time to time and any successor policies), and, pursuant to these policies, if
the Eligible Individual is on the Company’s insider list, the Eligible Individual shall be required to obtain pre-clearance from the Company’s General Counsel prior to purchasing or selling any of the Company’s securities (including
in connection with the “cashless” exercise of an Option), and may be prohibited from selling such shares other than during an open trading window. The Eligible Individual further acknowledges that, in its discretion, the Company may
prohibit the Eligible Individual from selling such shares even during an open trading window if the Company has concerns over the potential for insider trading. 
  

	10.	Nature of Award 

 In accepting the Option award, the Eligible Individual
acknowledges that: 
 (a) the Plan is established voluntarily by the Company, it is discretionary in nature and it may be modified, amended,
suspended or terminated by the Company at any time, unless otherwise provided in the Plan and this Agreement; 

  
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 (b) the award of the Option is voluntary and occasional and does not create any contractual or
other right to receive future awards of options, or benefits in lieu of options, even if options have been awarded repeatedly in the past; 

(c) all decisions with respect to future awards, if any, will be at the sole discretion of the Company; 

(d) the Eligible Individual’s participation in the Plan will not create a right to further employment with the Company, its Subsidiary or
Affiliate and shall not interfere with the ability of the Company to terminate the Eligible Individual’s employment relationship at any time with or without cause; 

(e) the Eligible Individual is voluntarily participating in the Plan; 

(f) the Option award is an extraordinary item that does not constitute compensation of any kind for services of any kind rendered to the
Company, Subsidiary, or Affiliate, and such award is outside the scope of the Eligible Individual’s employment contract, if any; 
 (g)
the Option award is not part of normal or expected compensation or salary for any purposes, including, but not limited to, calculating any severance, resignation, termination, redundancy, end of service payments, bonuses, long-service awards,
pension or retirement benefits or similar payments and in no event should be considered as compensation for, or relating in any way to, past services for the Company, Subsidiary or Affiliate; 

(h) in the event that the Eligible Individual is not an employee of the Company, a Subsidiary or an Affiliate, the Option award will not be
interpreted to form an employment contract or relationship with the Company, a Subsidiary or Affiliate; and furthermore, the Option award will not be interpreted to form an employment contract with the Company, a Subsidiary or Affiliate; and 

(i) in consideration of the award of the Option, no claim or entitlement to compensation or damages shall arise from termination of the Option
award or diminution in value of the Option award resulting from Termination of the Eligible Individual’s Employment by the Company, Subsidiary or Affiliate (for any reason whatsoever and whether or not in breach of local labor laws) and the
Eligible Individual irrevocably releases the Company, Subsidiary or Affiliate from any such claim that may arise; if, notwithstanding the foregoing, any such claim is found by a court of competent jurisdiction to have arisen, then, by signing this
Agreement, the Eligible Individual will be deemed irrevocably to have waived his or her entitlement to pursue such claim. 
  

	11.	No Advice Regarding Grant 

 The Company is not providing any tax, legal or
financial advice, nor is the Company making any recommendations regarding the Eligible Individual’s participation in the Plan, or his or her acquisition or sale of the underlying Shares. The Eligible Individual is hereby advised to consult with
his or her own personal tax, legal and financial advisors regarding the Eligible Individual’s participation in the Plan, receipt of the Award and/or disposition of the Award before taking any action related to the Plan or the Award. 

  
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	12.	Notices 

 Any notices, communications or changes to this Agreement shall be
communicated (either directly by the Company or indirectly through any of its Subsidiaries, Affiliates or the Plan Administrator) to the Eligible Individual electronically via email (or otherwise in writing) promptly after such change becomes
effective. 
  

	13.	Effect of Agreement; Severability  

 Except as otherwise provided hereunder, this
Agreement shall be binding upon and shall inure to the benefit of any successor or successors of the Company. The invalidity or enforceability of any provision of this Agreement shall not affect the validity or enforceability of any other provision
of this Agreement. 
  

	14.	Laws Applicable to Construction; Consent to Jurisdiction 

 (a) The
interpretation, performance and enforcement of this Agreement shall be governed by the laws of the State of Delaware without reference to principles of conflict of laws, as applied to contracts executed in and performed wholly within the State of
Delaware. In addition to the terms and conditions set forth in this Agreement, the Option is subject to the terms and conditions of the Plan, which are hereby incorporated by reference. 

(b) Any and all disputes arising under or out of this Agreement, including without limitation any issues involving the enforcement or
interpretation of any of the provisions of this Agreement, shall be resolved by the commencement of an appropriate action in the state or federal courts located within the State of Delaware, which shall be the exclusive jurisdiction for the
resolution of any such disputes. The Eligible Individual hereby agrees and consents to the personal jurisdiction of said courts over the Eligible Individual for purposes of the resolution of any and all such disputes. 

 

	15.	Conflicts and Interpretation 

 (a) In the event of any (i) conflict between
the Grant Details, this Agreement, any information posted on the system of the Plan Administrator and/or the books and records of the Company, or (ii) ambiguity in the Grant Details, this Agreement, any information posted on the system of the
Plan Administrator and/or the books and records of the Company, the Plan shall control. 
 (b) The Committee shall have the power to
interpret the Plan, this Agreement, the Grant Details, any information posted on the system of the Plan Administrator and/or the books and records of the Company, and to adopt such rules for the administration, interpretation and application of the
Plan and the Award as are consistent therewith and to interpret or revoke any such rules (including, but not limited to, the determination of whether or any Option has vested). All actions taken and all interpretations and determinations made by the
Committee in good faith shall be final and binding upon the Participant, the Company and all other interested parties. The Committee shall not be personally for any action, determination or interpretation made in good faith with respect to the Plan
or this Agreement. The Committee shall, in their absolute discretion, determine when any conditions have been fulfilled. 

  
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	16.	Data Privacy  

 (a) The Eligible Individual understands that the
Company, Subsidiary, Affiliate and/or Plan Administrator may hold certain personal information about him or her, including, but not limited to, the Eligible Individual’s name, home address and telephone number, date of birth, social insurance
number or other identification number, salary, nationality, job title, any shares of stock or directorships held in the Company, details of all options or any other entitlement to shares of stock awarded, canceled, exercised, vested, unvested or
outstanding in the Eligible Individual’s favor, for the purpose of implementing, administering and managing the Plan (“Data”). The Eligible Individual hereby explicitly and unambiguously consents to the collection, use
and transfer, in electronic or other form, of his or her Data as described in this document by and among, as applicable, the Company and its Subsidiaries or Affiliates for the exclusive purpose of implementing, administering and managing the
Eligible Individual’s participation in the Plan. 
 (b) The Eligible Individual understands that Data will be transferred
to the Plan Administrator, or such other stock plan service provider as may be selected by the Company in the future, which is assisting the Company with the implementation, administration and management of the Plan. The Eligible Individual
understands that the recipients of the Data may be located in the United States or elsewhere, and that the recipients’ country may have different data privacy laws and protections than the Eligible Individual’s country. The Eligible
Individual authorizes the Company, its Subsidiary or Affiliate, the Plan Administrator and any other possible recipients which may assist the Company (presently or in the future) with implementing, administering and managing the Plan to receive,
possess, use, retain and transfer the Data, in electronic or other form, for the sole purpose of implementing, administering and managing the Eligible Individual’s participation in the Plan. 

(c) The Eligible Individual understands that he or she may, at any time, view Data, request additional information about the storage and
processing of Data, require any necessary amendments to Data or refuse or withdraw the consents herein, in any case without cost, by contacting in writing the Eligible Individual’s local human resources representative. The Eligible Individual
understands, however, that refusing or withdrawing his or her consent may affect the Eligible Individual’s ability to participate in the Plan. For more information on the consequences of the Eligible Individual’s refusal to consent or
withdrawal of consent, the Eligible Individual understands that he or she may contact his or her local human resources representative. 
  

	17.	Amendment 

 (a) The Company may modify, amend or waive the terms of the Option
award, prospectively or retroactively, but no such modification, amendment or waiver shall impair the rights of the Eligible Individual without his or her consent, except as required by applicable law, NASDAQ or stock exchange rules, tax rules or
accounting rules. The waiver by either party of compliance with any provision of this Agreement shall not operate or be construed as a waiver of any other provision of this Agreement, or of any subsequent breach by such party of a provision of this
Agreement. 

  
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 (b) This Award and payments made pursuant to this Agreement and the Plan are intended to qualify
for an exemption from Section 409A of the Code. If the Company makes a good faith determination that any compensation provided under this Agreement is likely to be subject to the additional tax imposed by Section 409A, the
Company may, to the extent it deems necessary or advisable, modify this Agreement, without the Eligible Employee’s consent, to reduce the risk that such additional tax will apply, in a manner designed to preserve the material
economic benefits intended to be provided to the Eligible Employee under this Agreement (other than any diminution of such benefit that may be attributable to the time value of money resulting from a delay in the timing of payments hereunder
for a period of approximately six months or such longer period as may be required). 
  

	18.	Choice of Language 

 The Eligible Individual has received this Agreement and any
other related communications and consents to having received these documents solely in English. If, however, the Eligible Individual receives this or any other document related to the Plan translated into a language other than English and if the
translated version is different than the English version in any way, the English version will control. 
  

	19.	Electronic Delivery 

 The Company may, in its sole discretion, decide to deliver
any documents related to the Option awarded under and participation in the Plan or future options that may be awarded under the Plan by electronic means or to request the Eligible Individual’s consent to participate in the Plan by electronic
means. The Eligible Individual hereby consents to receive such documents by electronic delivery and, if requested, to agree to participate in the Plan through an on-line or electronic system established and maintained by the Company or another third
party designated by the Company. 
 By electronically accepting this Agreement and participating in the Plan, the Eligible Individual agrees
to be bound by the terms and conditions of the Plan and this Agreement, including the Grant Details. If Eligible Individual has not electronically accepted this Agreement on the Plan Administrator’s website within six months of the Award Date,
then this Award shall automatically by deemed accepted and Eligible Individual shall be bound by the terms and conditions in the Plan, this Agreement, including the Grant Details. 

  
 9EX-10.1

 Exhibit 10.1 

Execution Version 
 Voting
and Support Agreement 
 VOTING AND SUPPORT AGREEMENT, dated as of June 7, 2017 (this “Agreement”), by and between
GL Trade Investment Limited, a company incorporated under the laws of the Cayman Islands (the “Stockholder”), and SciClone Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used and
not otherwise defined herein shall have the respective meanings ascribed to them in the Merger Agreement (as defined below). 
 Recitals

 WHEREAS, as of the date hereof, the Stockholder is the beneficial owner of 4,750,116 Common Shares (together with such additional
shares of capital stock that become beneficially owned (within the meaning of Rule 13d-3 promulgated under the Exchange Act) by it, whether upon the exercise of options, conversion of convertible securities or otherwise, after the date hereof until
the Expiration Date, the “Subject Shares”); 
 WHEREAS, concurrently with the execution of this Agreement, Silver Biotech
Investment Limited, a company organized under the laws of the Cayman Islands (“Holdco”), Silver Delaware Investment Limited, a Delaware corporation and wholly-owned subsidiary of Holdco (“Merger Sub”), and the
Company are entering into an Agreement and Plan of Merger, dated as of the date hereof (the “Merger Agreement”), pursuant to which, upon the terms and subject to the conditions thereof, Merger Sub will be merged with and into the
Company (the “Merger”), with the Company surviving the Merger as a wholly owned subsidiary of Holdco; 
 WHEREAS,
concurrently with the execution of this Agreement, the Stockholder is entering into a Rollover Agreement with Holdco and Silver Biotech Holding Limited, a company organized under the laws of the Cayman Islands and the sole shareholder of Holdco
(“Topco”), pursuant to which, the Stockholder has agreed, among other things, to contribute all of the Subject Shares to Holdco immediately prior to the Effective Time in exchange for newly issued shares of Topco (the
“Rollover Agreement”); 
 WHEREAS, the Company Board has unanimously (i) determined that the Merger Agreement and the
transactions contemplated hereby, including the Merger, are advisable and fair to, and in the best interests of, the Company and its stockholders, (ii) adopted the Merger Agreement and the transactions contemplated thereby, including the
Merger, (iii) directed that the Merger Agreement be submitted to the stockholders of the Company for their approval and (iv) resolved to recommend that the stockholders of the Company approve the Merger Agreement; and 

WHEREAS, as a condition and inducement to the willingness of the Company to enter into the Merger Agreement, the Company has required that the
Stockholder enters into this Agreement, and the Stockholder desires to enter into this Agreement to induce the Company to enter into the Merger Agreement; 

 NOW, THEREFORE, in consideration of the foregoing and the mutual covenants and agreements
contained herein, and intending to be legally bound hereby, the parties hereby agree, severally and not jointly, as follows: 
 1. Voting
of Shares. From the period commencing with the execution and delivery of this Agreement and continuing until the Expiration Date, at every meeting of the stockholders of the Company called with respect to any of the following, and at every
adjournment or postponement thereof, and on every action or approval by written consent of the stockholders of the Company with respect to any of the following, the Stockholder shall vote or cause to be voted the Subject Shares that it is entitled
to vote: 
 (a) in favor of the adoption of the Merger Agreement and the approval of the transactions contemplated thereby, including the
Merger; and 
 (b) against any other action or agreement that is not recommended by the Company Board and that would reasonably be expected
to (A) result in a breach of any covenant, representation or warranty or any other obligation or agreement of the Company under the Merger Agreement, (B) result in any of the conditions to the consummation of the Merger under
the Merger Agreement not being fulfilled, or (C) impede, frustrate, interfere with, delay, postpone or adversely affect the Merger and the other transactions contemplated by the Merger Agreement. 

2. Transfer of Shares. The Stockholder covenants and agrees that during the period from the date of this Agreement through the
Expiration Date, it will not, directly or indirectly, (i) transfer, assign, sell, pledge, encumber, hypothecate or otherwise dispose (whether by sale, liquidation, dissolution, dividend or distribution) of or consent to any of the
foregoing (“Transfer”), or cause to be Transferred, any of the Subject Shares, (ii) deposit any of the Subject Shares into a voting trust or enter into a voting agreement or arrangement with respect to the Subject Shares
or grant any proxy or power of attorney with respect thereto that is inconsistent with this Agreement, (iii) enter into any contract, option or other arrangement or undertaking with respect to the Transfer of any Shares or
(iv) take any other action, that would materially restrict, limit or interfere with the performance of the Stockholder’s obligations hereunder. The foregoing restrictions on Transfers of Subject Shares shall not prohibit any such
Transfers by the Stockholder in connection with the transactions contemplated by the Merger Agreement, the Rollover Agreement or the Escrow Agreement. 

3. Additional Covenants of the Stockholder. 

(a) Further Assurances. From time to time and without additional consideration, each party hereto shall (at such party’s sole cost
and expense) execute and deliver, or cause to be executed and delivered, such additional instruments, and shall (at such party’s sole cost and expense) take all reasonable further actions for the purpose of carrying out the intent of this
Agreement. 
 (b) Waiver of Appraisal Rights. The Stockholder hereby waives, to the full extent of the law, and agrees not to assert
any appraisal rights pursuant to Section 262 of the DGCL or otherwise in connection with the Merger with respect to any and all Subject Shares. 

 4. Representations and Warranties of the Stockholder. The Stockholder on its own behalf
hereby represents and warrants to the Company with respect to the Stockholder and its ownership of the Subject Shares as follows: 
 (a)
Authority. The Stockholder has all requisite power and authority to enter into this Agreement and to consummate the transactions contemplated hereby. This Agreement has been duly authorized, executed and delivered by the Stockholder and
constitutes a valid and binding obligation of the Stockholder enforceable in accordance with its terms, except as enforcement may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’
rights generally and by general principles of equity (regardless of whether considered in a proceeding in equity or at law). Other than as provided in the Merger Agreement and any filings by the Stockholder with the Securities and Exchange
Commission, the execution, delivery and performance by the Stockholder of this Agreement does not require any consent, approval, authorization or permit of, action by, filing with or notification to any Governmental Entity, other than any consent,
approval, authorization, permit, action, filing or notification the failure of which to make or obtain would not, individually or in the aggregate, be reasonably expected to prevent or materially delay the consummation of the Merger or the
Stockholder’s ability to observe and perform its material obligations hereunder. 
 (b) No Conflicts. Neither the execution and
delivery of this Agreement, nor the consummation of the transactions contemplated hereby, nor compliance with the terms hereof, will violate, conflict with or result in a breach of, or constitute a default (with or without notice or lapse of time or
both) under any provision of, any trust agreement, loan or credit agreement, note, bond, mortgage, indenture, lease or other agreement, instrument, permit, concession, franchise, license, judgment, order, notice, decree, statute, law, ordinance,
rule or regulation applicable to the Stockholder or to its’s property or assets. 
 (c) The Subject Shares. The Stockholder is
the beneficial owner of, and has good and marketable title to, the Subject Shares free and clear of any and all security interests, liens, changes, encumbrances, equities, claims, options or limitations of whatever nature and free of any other
limitation or restriction (including any restriction on the right to vote, sell or otherwise dispose of such Subject Shares, but excluding any restriction provided by the Rollover Agreement and the Escrow Agreement and any restriction imposed by any
applicable securities laws), other than any of the foregoing that would not prevent or delay the Stockholder’s ability to perform its obligations hereunder. The Stockholder does not own, of record or beneficially, any shares of capital stock of
the Company other than the Subject Shares. Subject to the restrictions under the Rollover Agreement and the Escrow Agreement, the Stockholder have, or will have at the time of the applicable stockholder meeting, the sole right to vote or direct the
vote of, or to dispose of or direct the disposition of, such Subject Shares, and none of the Subject Shares is subject to any agreement, arrangement or restriction with respect to the voting of such Subject Shares that would prevent or delay the
Stockholder’s ability to perform its obligations hereunder (except the obligations under this Agreement). Except for the Rollover Agreement and the Escrow Agreement, (i) there are no agreements or arrangements of any kind, contingent or
otherwise, obligating the Stockholder to Transfer, or cause to be Transferred, any of the Subject Shares and (ii) no Person has any contractual or other right or obligation to purchase or otherwise acquire any of such Subject Shares. 

 (d) Reliance by the Company. The Stockholder understands and acknowledges that the Company
is entering into the Merger Agreement in reliance upon the Stockholder’s execution and delivery of this Agreement. 
 (e)
Litigation. As of the date hereof, to the knowledge of the Stockholder, there is no action, proceeding or investigation pending or threatened against the Stockholder that questions the validity of this Agreement or any action taken or to be
taken by the Stockholder it in connection with this Agreement. 
 5. Representations and Warranties of the Company. The Company
represents and warrants to the Stockholder as follows: 
 (a) Authority. The Company is a corporation duly incorporated, validly
existing and in good standing under the Laws of the State of Delaware and has full corporate power and authority to execute and deliver this Agreement and to consummate the transactions contemplated hereby. The execution and delivery of this
Agreement and the Merger Agreement by the Company and the consummation of the transactions contemplated hereby and thereby have been duly and validly authorized by the Company Board, and no other corporate proceedings on the part of the Company are
necessary to authorize the execution, delivery and performance of this Agreement, the Merger Agreement by the Company and the consummation of the transactions contemplated hereby and thereby. The Company has duly and validly executed this Agreement,
and this Agreement constitutes a legal, valid and binding obligation of the Company enforceable against the Company in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization or
other similar Laws affecting creditors’ rights generally and by general equitable principles (regardless of whether enforceability is considered in a proceeding in equity or at law). 

6. Termination. This Agreement shall automatically terminate without further action upon the earliest to occur (the “Expiration
Date”) of (A) the Effective Time, (B) the termination of the Merger Agreement in accordance with its terms, (C) the Company Board or any of its committees having made an Adverse Recommendation Change and (D) the written
agreement of the Stockholder and the Company to terminate this Agreement. 
 7. Specific Performance. The Stockholder acknowledges and
agrees that (a) the covenants, obligations and agreements contained in this Agreement relate to special, unique and extraordinary matters, (b) the Company is relying on such covenants in connection with entering into the Merger Agreement
and (c) a violation of any of the terms of such covenants, obligations or agreements will cause the Company irreparable injury for which adequate remedies are not available at law and for which monetary damages are not readily ascertainable.
Therefore, the Stockholder agrees that the Company shall be entitled to an injunction, restraining order or such other equitable relief (without the requirement to post bond) as a court of competent jurisdiction may deem necessary or appropriate to
restrain the Stockholder from committing any violation of such covenants, obligations or agreements. These injunctive remedies are cumulative and shall be the Company’s sole remedy under this Agreement unless the Company shall have sought and
been denied injunctive remedies, and such denial is other than by reason of the absence of violation of such covenants, obligations or agreements. 

 8. Governing Law; Jurisdiction. 

(a) This Agreement shall be deemed to be made in and in all respects shall be interpreted, construed and governed by and in accordance with the
laws of the State of Delaware without regard to the conflicts of law principles thereof. 
 (b) Except as set out below, each of the parties
hereto hereby irrevocably and unconditionally (i) consents to submit to the sole and exclusive jurisdiction of the courts of the State of Delaware or any court of the United States located in the State of Delaware (the “Delaware
Courts”) for any litigation arising out of or relating to this Agreement, or the negotiation, validity or performance of this Agreement, or the transactions contemplated hereby (and agrees not to commence any litigation relating thereto
except in such courts), (ii) waives any objection to the laying of venue of any such litigation in the Delaware Courts and (iii) agrees not to plead or claim in any Delaware Court that such litigation brought therein has been brought in
any inconvenient forum. 
 9. WAIVER OF JURY TRIAL. EACH PARTY ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE UNDER THIS
AGREEMENT IS LIKELY TO INVOLVE COMPLICATED AND DIFFICULT ISSUES, AND THEREFORE EACH SUCH PARTY HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY RIGHT SUCH PARTY MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING
OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT. EACH PARTY CERTIFIES AND ACKNOWLEDGES THAT (i) NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH
OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER, (ii) EACH PARTY UNDERSTANDS AND HAS CONSIDERED THE IMPLICATIONS OF THIS WAIVER, (iii) EACH PARTY MAKES THIS WAIVER VOLUNTARILY AND (iv) EACH
PARTY HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 9. 
 10.
Amendment; Waivers. Neither this Agreement nor any term hereof may be amended or otherwise modified other than by an instrument in writing signed by the Company and the Stockholder. No provision of this Agreement may be waived, discharged or
terminated other than by an instrument in writing signed by the party against whom the enforcement of such waiver, discharge or termination is sought. No failure or delay by any party in exercising any right, power or privilege hereunder shall act
as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, power or privilege hereunder. 

11. Assignment; No Third Party Beneficiaries. This Agreement shall not be assignable or otherwise transferable by a party without the
prior written consent of the other parties, and any attempt to so assign or otherwise transfer this Agreement without such consent shall be void and of no effect. This Agreement shall be binding upon the respective heirs, successors, legal
representatives and permitted assigns of the parties hereto. Nothing in this Agreement shall be construed as giving any Person, other than the parties hereto and their heirs, successors, legal representatives and permitted assigns, any right, remedy
or claim under or in respect of this Agreement or any provision hereof. 

 12. Notices. All notices, claims, demands and other communications hereunder shall be in
writing and shall be deemed given (a) when sent by e-mail of a.pdf attachment (with confirmation of receipt by non-automated reply e-mail from the recipient) (provided that any notice received by e-mail transmission or otherwise at the
addressee’s location on any Business Day after 5:00 p.m. (New York time) shall be deemed to have been received at 9:00 a.m. (New York time) on the next Business Day) or (b) when sent by an internationally recognized overnight
carrier (providing proof of delivery) or when delivered by hand, addressed to the respective parties at the following addresses (or such other address for a party as shall be specified by like notice): 

 

	 	(a)	If to the Company, by email to: 

 SciClone Pharmaceuticals, Inc. 

950 Tower Ln, Foster City, CA 94404 

United States 
 Attention:
Friedhelm Blobel 
 E-mail: FBlobel@SCICLONE.com 

with a copy (which shall not constitute notice) to: 

DLA Piper LLP (US) 
 555 Mission
Street, Suite 2400 
 San Francisco, California 94105-2933 

United States 
 Attention: Howard
Clowes 
 E-mail: howard.clowes@dlapiper.com 

and 
 DLA Piper LLP (US) 

2000 University Avenue 
 East Palo
Alto, California 94303-2214 
 United States 

Attention: Eric Wang 
 E-mail:
eric.wang@dlapiper.com 
  

	 	(b)	if to the Stockholder, by email to: 

 Unit 3001, China World Tower 2 

No. 1 Jian Guo Men Wai Avenue 

Beijing 100004, People’s Republic of China 

Attention: Ms. Shirley Lin 

E-mail: slin@gl-investment.com 

 with a copy (which shall not constitute notice) to: 

Skadden, Arps, Slate, Meagher & Flom LLP 

30/F China World Office 2 

No. 1 Jian Guo Men Wai Ave. 

Beijing, China 100004 
 Attention:
Peter Huang 
 E-mail: Peter.Huang@skadden.com 

13. Severability. Any term or provision of this Agreement which is invalid or unenforceable in any jurisdiction shall, as to that
jurisdiction, be ineffective to the sole extent of such invalidity or unenforceability without rendering invalid or unenforceable the remainder of such term or provision or the remaining terms and provisions of this Agreement in any jurisdiction. If
any provision of this Agreement is so broad as to be unenforceable, such provision shall be interpreted to be only so broad as is enforceable. 

14. Entire Agreement. This Agreement constitutes the entire agreement between the parties with respect to the subject matter hereof and
supersedes all prior agreements and understandings between the parties with respect thereto. No addition to or modification of any provision of this Agreement shall be binding upon either party unless made in writing and signed by both parties. 

15. Section Headings. The article and section headings of this Agreement are for convenience of reference only and are not to be
considered in construing this Agreement. 
 16. Counterparts. This Agreement may be executed in any number of counterparts, each such
counterpart being deemed to be an original instrument, and all such counterparts shall together constitute the same agreement. 

[Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first above
written. 
  

			
	 SCICLONE PHARMACEUTICALS, INC.
  

	By:	 	 /s/ Friedhelm Blobel

		 	Name: Friedhelm Blobel
		 	Title: President and Chief Executive Officer
	  
 GL TRADE INVESTMENT LIMITED

 

	By:	 	 /s/ Hu Chou Hui

		 	Name: Hu Chou Hui
		 	Title: Director

 [Signature Page to Voting and Support Agreement]

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