Document:

FIRST
AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT

          THIS
AGREEMENT is made as of the 3 day of May, 2012 by and among Macrocure Ltd., an Israeli company (the “Company”), and the
holders of Series A Preferred Shares, as listed in Schedule A hereto (the “Investors”).

W
I T N E S S E T H:

          WHEREAS,
the Company and certain of the Investors are parties to that certain Registration
Rights Agreement, dated as of March 30, 2011 (the “Previous Registration Rights Agreement”); and

          WHEREAS,
Section 15.6 of the Previous Registration Rights Agreement provides that the Previous Registration
Rights Agreement may be amended with the written consent of the Special Majority (as
such term is defined in the Previous Registration Rights Agreement), and the Investors
parties hereto constitute the Special Majority; and

          WHEREAS,
the Company and the Investors are parties to that certain Share Purchase Agreement
dated March 28, 2012 (the “Purchase Agreement”);

          WHEREAS,
the Company wishes to grant and the Investors wish to receive registration rights to the Investors, in accordance with the terms
of the Purchase Agreement;

          WHEREAS,
the parties hereto desire to terminate the Previous Registration Rights Agreement and replace
it in its entirety with the agreements and covenants set forth herein.

           NOW,
THEREFORE, THE PARTIES HEREBY AGREE AS FOLLOWS: 

	 	 	 
	1.	Definitions.
    For purposes of this Agreement:
	 	 	 
	 	1.1	The
    term “Act” means the United States Securities Act of 1933, as amended.
	 	 	 
	 	1.2	The
    term “Form F-3” means such form under the Act as in effect on the date hereof
    or any registration form under the Act subsequently adopted by the SEC
    that permits inclusion or incorporation of substantial information by reference to
    other documents filed by the Company with the SEC.
	 	 	 
	 	1.3	The
    term “Holder” means any person owning Registrable Securities or any
    assignee thereof in accordance with Section 10 hereof.
	 	 	 
	 	1.4	The
    term “Initial Offering” means the Company’s first firm commitment
    underwritten public offering of its Ordinary Shares registered under the Act or the
    equivalent law of another jurisdiction.
	 	 	 
	 	1.5	The
    term “1934 Act” means the United States Securities Exchange Act of 1934, as
    amended.
	 	 	 
	 	1.6	The
    term “register,” “registered,” and “registration” refer to a registration
    effected by preparing and filing a registration statement or
    similar document in compliance with the Act, and the declaration or ordering of effectiveness
    of such registration statement or document.

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	 	1.7	The
    term “Ordinary Shares” shall mean the Company’s ordinary shares having a nominal value of NIS 0.01
    per share.
	 	 	 
	 	1.8	The
    term “Permitted Transferees” has the meaning set forth in the Articles of Association of the Company, as
    they may be amended or replaced from time to time.
	 	 	 
	 	1.9	The
    term “Preferred A Shares” shall mean the Company’s Series A Preferred Shares
    having a nominal value of NIS 0.01 per share.
	 	 	 
	 	1.10	The
    term “Preferred Majority Holders” has the meaning set forth in the Articles of
    Association of the Company, as they may be amended or replaced from time to time.
	 	 	 
	 	1.11	The
    term “Registrable Securities” means (i) the Ordinary Shares issuable or issued
    upon conversion of the Preferred A Shares of the Company, (ii) all Ordinary
    Shares that any Investor (or its Permitted Transferee) may hereafter purchase
    pursuant to its preemptive rights, rights of first offer, anti-dilution protection,
    or otherwise provided that any such Ordinary Shares purchased is so purchased in connection
    with the Preferred A Shares (or in connection with Ordinary Shares issued or issuable
    upon conversion of the Preferred A Shares), or shares of Ordinary Shares issued on conversion or exercise of other
    securities so purchased, (iii) any Ordinary Shares of the Company issued as (or issuable upon the
    conversion or exercise of any warrant, right or other security that is issued as) a dividend or other distribution with respect
    to, or in exchange for, or in replacement of, the shares referenced in (i), and
    (ii) above. The number of shares of “Registrable Securities” outstanding
    shall be determined by the number of Ordinary Shares outstanding and/or issuable
    pursuant to then exercisable or convertible securities, that are, Registrable
    Securities.
	 	 	 
	 	1.12	The
    term “SEC” means the Securities and Exchange Commission. 
	 	 	 
	2.	Request
    for Registration.
	 	 	 
	 	2.1	Subject
    to the conditions of this Section 2, if the Company shall receive at any time
    that is six (6) months after the effective date of the Initial Offering a written request
    from the Holders holding at least 50% of the Registrable Securities in each case,
    then outstanding (the “Initiating Holders”) that the Company file a registration statement under the Act
    covering the registration of Registrable Securities, then the Company shall, within
    twenty (20) days of the receipt thereof, give written notice of such request to all Holders, and subject to the limitations
    of this Section 2, use best efforts to effect, as soon as practicable, the registration under
    the Act of all Registrable Securities that the Holders request to be registered in
    a written request received by the Company within twenty (20) days of the mailing
    of the Company’s notice pursuant to this Section 2.1.

 

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	 	2.2	If
    the Initiating Holders intend to distribute the Registrable Securities covered by their
    request by means of an underwritten public offering, they shall so advise the Company
    as a part of their request made pursuant to this Section 2 and the Company
    shall include such information in the written notice referred to in Section 2.1. In such event the right of any Holder to
    include its Registrable Securities in
    such registration shall be conditioned upon such Holder’s participation
    in such underwritten public offering and the inclusion of such Holder’s
    Registrable Securities in the underwritten public offering (unless otherwise
    mutually agreed by a majority in interest of the Initiating Holders and such Holder) to the extent provided herein. All Holders
    proposing to distribute their securities through such underwritten offering shall enter
    into an underwriting agreement in customary form with the underwriter or underwriters selected for such
    underwriting by a majority in interest of the Initiating Holders (which underwriter
    or underwriters shall be reasonably acceptable to the Company). Notwithstanding any other provision of this Section
    2, if the underwriter advises the Company that marketing factors require a limitation
    of the number of securities underwritten (including Registrable Securities), then
    the Company shall so advise all Holders of Registrable Securities that would otherwise
    be underwritten pursuant hereto, and the Company shall include in such registration, (i) first, the Registrable
    Securities requested to be included therein by the Holders requesting such registration
    (the securities so included to be allocated between the Holders on a pro rata basis based on the number of Registrable
    Securities held by all such Holders), (ii) second, shares which the Company may
    wish to register for its own account, and (iii) third, other securities requested and entitled to be
    included in such registration provided, however, that in any event all
    Registrable Securities must be included in such registration prior to any other
    securities of the Company. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw
    therefrom by written notice to the Company and the underwriter, delivered at least twenty (20) days prior to the effective
    date of the registration statement. Any Registrable Securities excluded or withdrawn
    from such underwritten public offering shall be withdrawn from the registration.
	 	 	 	 
	 	2.3	The
    Company shall not be required to effect a registration pursuant to this Section
    2:
	 	 	 	 
	 	 	(a)	in any particular
    jurisdiction in which the Company would be required to execute a general consent to
    service of process in effecting such registration, unless the Company is already subject to service in such jurisdiction
    and except as may be required under the Act; it being understood that if the Company
    has registered its securities in a certain state in the United States in which
    a registration is required by the Holders pursuant to this Section 2– it will not
    be able to excuse itself from the demand request based on this exclusion; or
	 	 	 	 
	 	 	(b)	after
    the Company has effected three (3) registrations pursuant to this Section
    2, and such registrations have been declared or ordered effective; or
	 	 	 	 
	 	 	(c)	if
    the Initiating Holders, together with the holders of any other securities of the
    Company entitled to inclusion in such registration, propose to sell Registrable
    Securities and such other securities (if any) at an aggregate price to
    the public (net of any underwriters’ discounts or commissions) of less than
    $5,000,000; or

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	 	 	(d)	within a period
    of one hundred eighty (180) days following the effective date of
    a previous registration.
	 	 	 	 
	 	 	(e)	If the Company
    shall furnish to all the holders of Registrable Securities who joined
    in the request for registration pursuant to Section 2.1 above a certificate
    signed by the Chief Executive Officer of the Company or Chairman
    of the Board of Directors according to which in the good faith judgment
    of the Board of Directors of the Company, it would be seriously detrimental
    to the Company for any registration to be effected as requested under Section 2.1, then the Company shall have the right to
    defer the filing of a registration statement
    under the Securities Act with respect to such requested
    offering for a period of not more than ninety (90) days from delivery
    of the request of the Initiating Holders; provided, however, that the Company
    may not utilize this right more than once in any twelve-month period.
	 	 	 	 
	 	2.4	For purposes of Section
    2, the Initiating Holders shall be entitled to determine that a registration shall not
    be counted as “effected” if, as a result of an exercise of the underwriter’s
    cutback provisions in Section 2.2, fewer than fifty percent (50%) of the total
    number of Registrable Securities that Holders have requested to be included in
    such registration statement are actually included, provided that during the term of this Agreement, the Initiating Holders
    shall only be entitled to make a determination under this Section 2.4 two (2) times.
	 	 	 	 
	3.	Company
    Registration.
	 	 	 	 
	 	3.1	If
    (but without any obligation to do so) at anytime which is six (6) months after the Company’s
    Initial Offering), the Company proposes to register (including for this purpose
    a registration effected by the Company for shareholders other than the Holders)
    any of its shares or other securities under the Act in connection with the public
    offering of such securities (other than demand registrations under Section 2.1 or Section 4 or a registration relating solely
    to the sale of securities to participants in a Company share option plan, a registration relating to a corporate reorganization
    or other transaction listed in Rule
    145(a) of the Act or a registration on any form that does
    not include substantially the same information as would be required to be included
    in a registration statement covering the sale of the Registrable Securities), the Company shall, at such time, promptly give
    each Holder written notice of such registration. Upon the written request of each Holder given within twenty (20) days after
    delivery of such notice by the Company in accordance with Section 15.5, the Company shall, subject to the provisions of Section
    3, use all best efforts to cause to be
    registered under the Act all of the Registrable Securities that each such Holder has
    requested to be registered. If a Holder decides not to include all of its Registrable
    Securities in any registration statement thereafter filed by the Company, such Holder shall nevertheless continue to have
    the right to include any Registrable Securities in any subsequent registration statement or registration statements as may
    be filed by the Company with respect
    to offerings of its securities, all upon the terms
    and conditions set forth herein.

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	 	3.2	Right to
    Terminate Registration. The Company shall have the right to terminate or withdraw
    any registration initiated by it under this Section 3 prior to the effectiveness
    of such registration whether or not any Holder has elected to include securities
    in such registration. The expenses of such withdrawn registration shall be borne by the Company in accordance with Section
    7 hereof.
	 	 	 
	 	3.3	Underwriting
    Requirements. In connection with any underwritten public offering of shares
    of the Company’s share capital under this Section 3, the Company shall not be
    required under this Section 3 to include any of the Holders’ securities in such offering unless they accept the terms
    of the underwriting as agreed upon between the Company and the underwriters selected by it (or by other persons entitled to
    select the underwriters) and enter into an underwriting agreement in customary form with
    an underwriter or underwriters selected by the Company, and then only in such quantity as the underwriters determine in their
    sole discretion will not jeopardize the success of the offering by the Company
    based on marketing factors. If the total amount of securities, including Registrable
    Securities, requested by shareholders to be included in such offering exceeds the amount of securities sold other than by
    the Company that the underwriters determine in their sole discretion is allowed based on
    marketing factors, then the Company shall be required to include in the offering only
    that number of such securities, including Registrable Securities, that the underwriters
    determine in their sole discretion will not jeopardize the success of the offering
    and the Company shall include in such registration, (i) first, shares which the Company may wish to register
    for its own account, (ii) second, the Registrable Securities requested
    to be included therein by the Holders (the securities so included to be allocated
    between the Holders on a pro rata basis based on the number of Registrable Securities held by all such Holders) and (iii)
    third, other securities requested to be included in such registration.
    Notwithstanding the foregoing, in no event shall the number of Registrable Securities
    included in the offering be reduced unless all other securities (other than securities
    to be sold by the Company) are first entirely excluded from the offering. If
    any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by written notice
    to the Company and the underwriter, delivered at least twenty (20) days prior
    to the effective date of the registration statement. Any Registrable Securities
    excluded or withdrawn from such underwriting shall be excluded and withdrawn from
    the registration.
	 	 	 
	 	3.4	Subject to Section 12 below, there
    shall be no limit on the number of times that a Holder may request registration of Registrable
    Securities under this Section 3, and registrations effected pursuant to this Section
    3 shall not be counted as requests for registration effected pursuant to Section
    2.
	 	 	 

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	4.	Form
    F-3 Registration.
	 	 	 
	 	In
    case the Company shall receive from the Initiating Holders a written request or requests that
    the Company effect a registration on Form F-3, at a time when the Company is eligible
    to register securities for a secondary offering by its stockholders on SEC Securities
    Act Form F-3 (or any successor form to Form F-3, regardless of its designation),
    the Company shall:
	 	 	 	 
	 	4.1	within
    ten (10) days after receipt of any such request, give written notice of the proposed
    registration, and any related qualification or compliance, to all other Holders;
    and
	 	 	 	 
	 	4.2	use
    its best efforts to effect, as soon as practicable, such registration and all such qualifications
    and compliances as may be so requested and as would permit or facilitate
    the sale and distribution of all or such portion of such Holders’ Registrable Securities
    as are specified in such request, together with all or such portion of the Registrable
    Securities of any other Holders joining in such request as are specified in a
    written request given within fifteen (15) days after receipt of such written notice from
    the Company; provided, however, that the Company shall not be obligated to effect
    any such registration, qualification or compliance, pursuant to this Section 4:
	 	 	 	 
	 	 	(a)	if Form F-3
    is not available for such offering by the Holders;
	 	 	 	 
	 	 	(b)	if the Holders,
    together with the holders of any other securities of the Company
    entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an
    aggregate price to the public (net of
    any underwriters’ discounts or commissions) of less than
    $1,000,000;
	 	 	 	 
	 	 	(c)	if the Company
    has, within the twelve (12) month period preceding the date of
    such request, already effected two registrations on Form F-3 for the Holders
    pursuant to this Section 4; or
	 	 	 	 
	 	 	(d)	in any particular jurisdiction in which
    the Company would be required to qualify to do business or to execute a general consent
    to service of process in effecting such registration, qualification or compliance;
    it being understood that if the Company has registered its securities in a certain
    state in the United States in which a registration is required pursuant to this
    Section 24 – it will not be able to excuse itself from the request based on this
    exclusion.
	 	 	 	 
	 	 	(e)	If the Company
    shall furnish to all the holders of Registrable Securities who joined
    in the request for registration pursuant to Section 4 a certificate signed by
    the Chief Executive Officer or Chairman of the Board of Directors of the Company
    according to which in the good faith judgment of the Board of Directors
    of the Company, it would be seriously detrimental to the Company for
    any registration to be effected as requested under Section 4, then the Company
    shall have the right to defer the filing of a registration statement under the Securities
    Act with respect to such requested offering for a period of not more than ninety
    (90) days from delivery of the request of the Holders in accordance with Section 4.1 above; provided, however, that the Company
    may not utilize this right more than once in any twelve-month period; and provided
    further that the Company shall not register any securities for the account of itself or any other shareholder during
    such 90-day period (other than (i) a registration relating solely to the sale of securities
    of participants in a Company equity incentive plan or a corporate reorganization
    or transaction under Rule 145 of the Act, a registration or (ii) a registration
    by the Company which commenced prior to the registration provided under this Section
    4).

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	 	4.3	Subject to the foregoing,
    the Company shall file a registration statement covering the Registrable Securities and
    other securities so requested to be registered as soon as practicable after receipt of the request or requests of the Holders.
    Registrations effected pursuant to this Section 4 shall not be counted as requests
    for registration effected pursuant to Section 2 and there shall be no limit on such requests.
	 	 	 	 
	5.	Obligations
    of the Company.
	 	 	 	 
	 	Whenever required under
    this Agreement to effect the registration of any Registrable Securities, the Company
    shall, as expeditiously as reasonably possible:
	 	 	 	 
	 	5.1	prepare
    and file with the SEC a registration statement with respect to such Registrable
    Securities and use its best commercial efforts to cause such registration statement
    to become effective, and, upon the request of the Holders holding a majority
    of the Registrable Securities registered thereunder, keep such registration statement
    effective for a period of up to (i) one hundred eighty (180) days, (ii) in the event
    of a Form F-3 registration, for a period of up to two hundred and seventy (270)
    days or, (iii) in either case, if earlier, until the distribution contemplated in the Registration Statement has been completed;
	 	 	 	 
	 	5.2	prepare
    and file with the SEC such amendments and supplements to such registration
    statement and the prospectus used in connection with such registration statement
    as may be necessary to comply with the provisions of the Act with respect to
    the disposition of all securities covered by such registration statement;
	 	 	 	 
	 	5.3	furnish
    to the Holders such numbers of copies of a prospectus, including a preliminary
    prospectus, in conformity with the requirements of the Act, and such other
    documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them;
	 	 	 	 
	 	5.4	use
    its best efforts to register and qualify the securities covered by such registration statement
    under such other securities or Blue Sky laws of such jurisdictions as shall be
    requested by the Holders, provided that the Company shall not be required in connection therewith or as a condition thereto
    to qualify to do business or to file a general consent to service of process in any
    such states or jurisdictions;
	 	 	 	 
	 	5.5	in
    the event of any underwritten public offering, enter into and perform its obligations
    under an underwriting agreement, in usual and customary form, with the managing underwriter of such offering;
	 	 	 	 
	 	5.6	notify
    each Holder of Registrable Securities covered by such registration statement at any time when a prospectus relating thereto
    is required to be delivered under the Act
    or the happening of any event as a result of which the prospectus included in such
    registration statement, as then in effect, includes an untrue statement of a material
    fact or omits to state a material fact required to be stated therein or necessary
    to make the statements therein not misleading in the light of the circumstances then
    existing;

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	 	5.7	cause all such Registrable Securities
    registered pursuant hereunder to be listed on each securities exchange on which similar securities issued by the Company are
    then listed;
	 	 	 
	 	5.8	provide a transfer
    agent and registrar for all Registrable Securities registered pursuant
    hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration;
	 	 	 
	 	5.9	furnish, at
    the request of any Holder requesting registration of Registrable Securities pursuant
    to this Agreement, on the date that such Registrable Securities are delivered
    to the underwriters for sale in connection with a registration pursuant to this Agreement, if such securities are being sold
    through underwriters, or, if such securities are not being sold through underwriters,
    on the date that the registration statement with respect to such securities becomes
    effective, (i) an opinion, dated such date, of the counsel representing the Company
    for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten
    public offering, addressed to the underwriters, if any, and to the Holders requesting
    registration of Registrable Securities and (ii) a letter dated such date, from
    the independent certified public accountants of the Company, in form and substance
    as is customarily given by independent certified public accountants to underwriters
    in an underwritten public offering, addressed to the underwriters, if any, and
    to the Holders requesting registration of Registrable Securities.
	 	 	 
	6.	Information
    from Holder. It shall be a condition precedent to the obligations of the Company
    to take any action pursuant to this Agreement with respect to the Registrable Securities
    of any selling Holder that such Holder shall furnish to the Company such information
    regarding itself, the Registrable Securities held by it, and the intended method of
    disposition of such securities as shall be reasonably requested in writing by the Company
    and as shall be required in accordance with applicable law to effect the registration
    of such Holder’s Registrable Securities, and with respect to any underwritten registration hereunder that such
    Holder completes and executes all questionnaires and powers of attorney, indemnities,
    underwriting agreements, and other documents required under the terms of such
    underwriting arrangements to which such Holder is subject to in accordance with
    the terms hereof.
	 	 	 
	7.	Expenses
    of Registration. Except for underwriting discounts and commissions (which
    shall be borne by the Holders pro rata based upon the number of Registrable Securities that
    are included in the registration) all expenses incurred in connection with registrations, filings
    or qualifications pursuant to Sections 2, 3 and 4, including (without limitation) all registration,
    filing and qualification fees, printers’ and accounting fees, fees and disbursements
    of counsel for the Company and the reasonable fees and disbursements of one counsel
    for the selling Holders, shall be borne by the Company. Notwithstanding the foregoing, the Company shall not be required to
    pay for any expenses of any registration proceeding begun pursuant to Section 2 or Section 4 if the registration request
    is subsequently withdrawn at the request of the Holders holding a majority of the Registrable
    Securities to be registered (in which case all participating Holders shall bear such expenses pro rata based upon the number
    of Registrable Securities that were to be requested in the withdrawn registration),
    unless, in the case of a registration requested under Section 2, the Holders holding a majority of the Registrable
    Securities agree to forfeit their right to one demand registration pursuant to Section
    2; provided, however, that if at the time of such withdrawal, the Holders have learned of a material adverse change
    in the condition, business, or prospects of the Company from that known to the Holders
    at the time of their request and have withdrawn the request with reasonable promptness
    following disclosure by the Company of such material adverse change, or if such withdrawal is based on the advice of the managing
    underwriter due to an adverse change in the condition, business, or prospects
    of the Company, in each case the Holders shall not be required to pay any of such
    expenses and shall retain their rights pursuant to Section 2 or 4 (e.g. such registrations
    shall not be counted on account of demand registration).

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	8.	Indemnification.
    In the event any Registrable Securities are included in a registration statement under
    this Agreement:
	 	 	 
	 	8.1	To the extent
    permitted by law, the Company will indemnify and hold harmless each
    Holder, the partners, members or officers, directors and shareholders of each Holder,
    any underwriter (as defined in the Act) for such Holder and each person, if any, who controls such Holder or underwriter within
    the meaning of the Act or the 1934 Act
    (a “Holder Indemnitee”), against any losses, claims, damages or liabilities
    (joint or several) to which they may become subject under the Act, the 1934 Act or any state securities laws, insofar as such
    losses, claims, damages, or liabilities
    (or actions in respect thereof) arise out of or are based upon any of the following
    statements, omissions or violations (collectively a “Violation”): (i) any untrue
    statement or alleged untrue statement of a material fact contained in such registration
    statement, including any preliminary prospectus or final prospectus contained
    therein or any amendments or supplements thereto or any disclosure package filed with
    the SEC, (ii) the omission or alleged omission to state therein a material fact
    required to be stated therein, or necessary to make the statements therein not
    misleading, or (iii) any violation or alleged violation by the Company of the Act,
    the 1934 Act, any state securities laws or any rule or regulation promulgated
    under the Act, the 1934 Act or any state securities laws; and the Company will
    reimburse each such Holder Indemnitee promptly upon demand for any legal or other
    expenses reasonably incurred by them in connection with investigating or defending
    any such loss, claim, damage, liability or action; provided, however, that
    the indemnity agreement contained in this subsection 8.1 shall not apply to amounts
    paid in settlement of any such loss, claim, damage, liability or action if such
    settlement is effected without the consent of the Company (which consent shall
    not be unreasonably withheld), nor shall the Company be liable in any such case
    to a Holder Indemnitee for any such loss, claim, damage, liability or action
    to the extent that it arises out of or is based upon a Violation that occurs in reliance upon and in conformity with
    written information furnished expressly for use in connection with such registration
    statement by such Holder Indemnitee; provided further, however, that the
    foregoing indemnity agreement insofar as they relate to any preliminary prospectus
    shall not inure to the benefit of any Holder Indemnitee, from whom the person
    asserting any such losses, claims, damages or liabilities purchased shares in the offering, if a copy of the prospectus
    (as then amended or supplemented if the Company shall have furnished any amendments or
    supplements thereto) was not sent or given by or on behalf of such Holder Indemnitee,
    if required by law so to have been delivered, at or prior to the written confirmation
    of the sale of the shares to such person, and if the prospectus (as so amended
    or supplemented) would have cured the defect giving rise to such loss, claim, damage or liability. Such indemnity shall remain
    in full force and effect regardless of any investigation made by or on behalf
    of the Holder Indemnitee.

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	8.2	To the extent permitted by law, each
    selling Holder will severally and not jointly, indemnify and hold harmless the Company,
    each of its directors, each of its officers, each person, if any, who controls
    the Company within the meaning of the Act, any underwriter, any other Holder selling securities in such registration
    statement and any controlling person of any such underwriter or other Holder, against
    any losses, claims, damages or liabilities (joint or several) to which any of the
    foregoing persons may become subject, under the Act, the 1934 Act or any state securities laws, insofar as such losses,
    claims, damages or liabilities (or actions in respect thereto) arise out of or are based
    upon any Violation, in each case to the extent (and only to the extent) that such
    Violation occurs in reliance upon and in conformity with written information
    furnished by such Holder expressly for use in connection with such registration statement; and each such Holder will
    reimburse any person intended to be indemnified pursuant to this subsection 8.2, for
    any legal or other expenses reasonably incurred by such person in connection with investigating or defending
    any such loss, claim, damage, liability or action; provided, however, that the
    indemnity agreement contained in this subsection 8.2 shall not apply to amounts paid
    in settlement of any such loss, claim, damage, liability or action if such settlement
    is effected without the consent of the Holder (which consent shall not be unreasonably
    withheld); provided further that in no event shall any indemnity under this subsection
    8.2 exceed the net proceeds from the offering received by such Holder.
	 	 
	8.3	Promptly after
    receipt by an indemnified party under this Section 8 of notice of the commencement
    of any action (including any governmental action) involving the subject
    matter of the foregoing indemnity provisions, such indemnified party will, if a
    claim in respect thereof is to be made against any indemnifying party under this Section
    8, deliver to the indemnifying party a written notice of the commencement thereof
    and the indemnifying party shall have the right to participate in, and, to the extent
    the indemnifying party so desires, jointly with any other indemnifying party similarly
    noticed, to assume the defense thereof with counsel mutually satisfactory to the
    parties; provided, however, that an indemnified party (together with all other indemnified
    parties that may be represented without conflict by one counsel) shall have the right to retain one separate counsel, with
    the fees and expenses to be paid by the indemnifying party, if representation of
    such indemnified party by the counsel retained by the indemnifying party would
    be inappropriate due to actual or potential differing interests between such indemnified party and any other party
    represented by such counsel in such proceeding. The failure to deliver written notice
    to the indemnifying party within a reasonable time of the commencement of any
    such action, only if prejudicial to its ability to defend such action, shall relieve such
    indemnifying party of any liability to the indemnified party under this Section
    8 but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that
    it may have to any indemnified party otherwise than under this Section 8. After notice from the indemnifying party to such
    indemnified party of its election so to assume the defense thereof, the indemnifying
    party will not be liable to such indemnified party pursuant to the provisions of this Section 8 for any legal or other expense
    subsequently incurred by such indemnified party in connection with the defense
    thereof, unless (i) the indemnified party shall have employed counsel in accordance
    with the provision of the preceding sentence, (ii) the indemnifying party shall
    not have employed counsel reasonably satisfactory to the indemnified party to
    represent the indemnified party within a reasonable time after the notice of the
    commencement of the action and within 15 days after written notice of the indemnified
    party’s intention to employ separate counsel, or (iii) the indemnifying
    party has authorized the employment of counsel for the indemnified party at the
    expense of the indemnifying party. No indemnifying party will consent to entry
    of any judgment or enter into any settlement, which does not include as an unconditional
    term thereof the giving by the claimant or plaintiff to such indemnified party
    a release from all liability in respect to such claim or litigation.

    	10

    	 

    

 

	 	 
	8.4	If the indemnification
    provided for in this Section 8 is held by a court of competent jurisdiction
    to be unavailable to an indemnified party with respect to any loss, liability,
    claim, damage or expense referred to herein, then the indemnifying party, in
    lieu of indemnifying such indemnified party hereunder, shall, subject to the limitation
    set forth in this Section 8.4, contribute to the amount paid or payable by such indemnified party as a result of such loss,
    liability, claim, damage or expense in such proportion as is appropriate to reflect the relative fault of the indemnifying
    party on the one hand and of the indemnified party on the other in connection with the
    statements or omissions that resulted in such loss, liability, claim, damage or expense,
    as well as any other relevant equitable considerations. Notwithstanding anything to the
    contrary contained herein, in no event shall the contribution obligation of any
    Holder set forth in this Section 8.4 exceed the net proceeds from the offering
    of Registrable Securities received by such Holder. The relative fault of the indemnifying
    party and of the indemnified party shall be determined by reference to, among
    other things, whether the untrue or alleged untrue statement of a material fact
    or the omission to state a material fact relates to information supplied by the
    indemnifying party or by the indemnified party and the parties’ relative intent,
    knowledge, access to information, and opportunity to correct or prevent such statement
    or omission.
	 	 
	8.5	Notwithstanding
    the foregoing, to the extent that the provisions on indemnification and
    contribution contained in the underwriting agreement entered into in connection with
    the underwritten public offering are in conflict with the foregoing provisions, the
    provisions in the underwriting agreement shall control.
	 	 
	8.6	The obligations
    of the Company and Holders under this Section 8 shall survive the completion
    of any offering of Registrable Securities in a registration statement under
    this Agreement, and otherwise.

    	11

    	 

    

 

	 	 	 
	9.	Reports
    Under Securities Exchange Act of 1934. With a view to making available to the Holders
    the benefits of Rule 144 promulgated under the Act (“SEC Rule 144”) and any other
    rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public
    without registration or pursuant to a registration on Form F-3, the Company agrees to:
	 	 	 
	 	9.1	make and keep
    public information available, as those terms are understood and defined
    in SEC Rule 144, at all times after the effective date of the Initial Offering;
	 	 	 
	 	9.2	file with
    the SEC in a timely manner all reports and other documents required of the Company under the Act and the 1934 Act; and
	 	 	 
	 	9.3	furnish to
    any Holder, so long as the Holder owns any Registrable Securities, forthwith
    upon request (i) a written statement by the Company that it has complied with
    the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the Company’s
    Initial Offering), the Act and the 1934 Act (at any time after
    it has become subject to such reporting requirements), or that it qualifies as a registrant
    whose securities may be resold pursuant to Form F-3 (at any time after it so qualifies),
    (ii) a copy of the most recent annual or quarterly report of the Company and
    such other reports and documents so filed by the Company with the SEC, and (iii)
    such other information as may be reasonably requested in availing any Holder of
    any rule or regulation of the SEC that permits the selling of any such securities
    without registration or pursuant to such form.
	 	 	 
	10.	Assignment
    of Registration Rights. The rights to cause the Company to register Registrable
    Securities pursuant to this Agreement may be assigned (but only with all related
    obligations and together with the transfer of some or all of the Registrable Securities
    (which transfer shall comply with all relevant restrictions on transfer of securities
    of the Company under applicable law, including without limitation, those specified
    in the Company’s Articles of Association, as amended from time to time) by a Holder
    to a transferee or assignee of such securities; provided: (a) the Company is, within a
    reasonable time after such transfer, furnished with written notice of the name and address of such transferee or assignee
    and the securities with respect to which such registration rights are being assigned;
    (b) such transferee or assignee agrees in writing, in a form reasonably satisfactory to the Company, to be bound by
    and subject to the terms and conditions of this Agreement, including without limitation
    the provisions of Section 11 below.
	 	 	 
	11.	“Market Stand-Off”
    Agreement. Each Holder hereby agrees that it will not, without the prior written
    consent of the managing underwriter, during the period commencing on the date
    of the final prospectus relating to the Initial Offering and ending on the date specified by the Company and the managing
    underwriter (such period not to exceed one hundred eighty (180) days) (i) lend, offer,
    pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any
    option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any Ordinary Shares or
    any securities convertible into or exercisable or exchangeable for Ordinary Shares (whether
    such shares or any such securities are then owned by the Holder or are thereafter acquired by the Holder during the
    180 days period), or (ii) enter into any swap or other arrangement that transfers to
    another, in whole or in part, any of the economic consequences of ownership of
    the Ordinary Shares, whether any such transaction described in clause (i) or
    (ii) above is to be settled by delivery of Ordinary Shares or such other securities,
    in cash or otherwise. The foregoing provisions of this Section 11 shall only apply
    to the Initial Offering, shall not apply to the sale of any shares to an underwriter
    pursuant to an underwriting agreement, and shall be applicable to the Holders if
    all officers and directors and shareholders of the Company holding more than one percent
    (1%) of the Company’s then existing fully diluted share capital, enter into similar agreements. Each Holder further
    agrees to execute such agreements as may be reasonably requested by the underwriters
    in the offering to the public (including without limitation, the Initial Offering)
    that are consistent with this Section 11 or that are necessary to give further
    effect thereto. The underwriters are intended third party beneficiaries of this Section
    11 and shall have the right, power and authority to enforce the provisions hereof as
    though they were a party hereto.

    	12

    	 

    

 

	 	 	 
	 	In
    order to enforce the foregoing covenant, the Company may impose stop-transfer instructions
    with respect to the Registrable Securities of each Holder (and the shares or securities of every other person subject to the
    foregoing restriction) until the end of such period.
	 	 	 
	12.	Termination of Registration
    Rights. No Holder shall be entitled to exercise any right provided for in this Agreement
    upon the earlier to occur of the following: (i) five (5) years following the
    consummation of the Initial Offering or (ii) as to any Holder, such time at which such Holder (together with any affiliates
    of the Holder with whom such Holder must aggregate its sales under Rule 144 promulgated under the Act) is able to sell all
    Registrable Securities within any three (3) month period.
	 	 	 
	13.	Limitations
    on Subsequent Registration Rights. From and after the date of this Agreement,
    the Company shall not, without the prior written consent of the Preferred Majority Holders,
    enter into any agreement with any holder or prospective holder of any securities
    of the Company that would allow such holder or prospective holder to include such securities in any registration filed
    under this Agreement hereof, unless under the terms of such agreement, such holder or
    prospective holder may include such securities in any such registration only to the extent that the inclusion of such securities
    will not reduce the amount of the Registrable Securities of the Holders that are
    included and shall be subordinated to the rights of any Holder hereunder.
	 	 	 
	14.	Foreign
    Offerings. The provisions of this Agreement shall apply, mutatis mutandis, to any registration of the securities of the
    Company outside of the United States.
	 	 	 
	15.	Miscellaneous.
	 	 	 
	 	15.1 	Successors
    and Assigns. Except as otherwise provided herein, the terms and conditions
    of this Agreement shall inure to the benefit of and be binding upon the respective
    successors and assigns of the parties (including transferees of any shares of
    Registrable Securities). Nothing in this Agreement, express or implied, is intended
    to confer upon any party other than the parties hereto or their respective successors
    and assigns any rights, remedies, obligations, or liabilities under or by reason
    of this Agreement, except as expressly provided in this Agreement.

    	13

    	 

    

 

	 	 	 
	 	15.2	Governing
    Law. This Agreement shall be governed by and construed under the laws
    of the State of Israel as applied to agreements among Israeli residents entered into
    and to be performed entirely within the State of Israel, except that all matters governed
    by or relating to the federal securities laws of the United States of America
    shall be interpreted in accordance with such laws. Any dispute arising under
    or in relation to this Agreement shall be resolved by the competent courts in Tel
    Aviv – Yafo, Israel, and each of the parties hereby submits exclusively and irrevocably
    to the jurisdiction of such court.
	 	 	 
	 	15.3	Counterparts.
    This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together
    shall constitute one and the same instrument.
	 	 	 
	 	15.4	Titles and
    Subtitles. The titles and subtitles used in this Agreement are used for convenience
    only and are not to be considered in construing or interpreting this Agreement.
	 	 	 
	 	15.5	Notices.
    Any notice required or permitted by any provision of this Agreement shall be
    given in writing and shall be delivered personally, by courier, by facsimile, electronic
    mail or by registered or certified mail, postage prepaid, addressed (i) in the case of
    the Company, to its principal office; (ii) in the case of any Investor which is an original party to this Agreement
    at the address of such Investor as set forth in the records of the Company or such other
    address for such Investor as shall be designated in writing from time to time
    to such Investor; and, (iii) in the case of any permitted transferee of a party
    to this Agreement or its transferee, to such transferee at its address as designated
    in writing by such transferee to the Company from time to time. Notices that are mailed shall be deemed received five
    (5) days after deposit in registered or certified mail, return receipt requested. Notices
    sent by courier or overnight delivery shall be deemed received two (2) days after
    they have been so sent. Notices sent by facsimile or email shall be deemed received on the first
    business day following transmission and electronic confirmation of receipt.
	 	 	 
	 	15.6	Entire Agreement: Amendments and
    Waivers. This Agreement (including the schedules hereto, if any) constitutes the
    full and entire understanding and agreement among the parties with regard to
    the subjects hereof and thereof. Any term of this Agreement may be amended and
    the observance of any term of this Agreement may be waived (either generally or in a particular instance and either
    retroactively or prospectively) with the written consent of the Company and the Preferred
    Majority Holders. Any amendment or waiver effected in accordance with this paragraph
    shall be binding upon the Investors, their future transferees and the Company. Notwithstanding
    the foregoing, to the extent any amendment to this Agreement adversely affects
    the rights of a specific Holder hereunder in a manner which discriminates such Holder against other Holders (taking into account
    existing differences, including without limitation, in number of Registrable
    Securities and/or class thereof), such amendment shall require the written approval of such Holder. For
    the avoidance of doubt, the following amendments shall not be deemed to adversely
    affect a specific Holder: (i) amendments setting minimum holding thresholds for
    rights under this Agreement, (ii) amendments to add a new series of preferred
    shares of the Company to the definitions of Holder, Preferred Shares, Registrable
    Securities and/or Investors.

    	14

    	 

    

 

	 	 	 
	 	15.7	Severability.
    If one or more provisions of this Agreement are held to be unenforceable
    under applicable law, such provision shall be excluded from this Agreement
    and the balance of the Agreement shall be interpreted as if such provision
    were so excluded and shall be enforceable in accordance with its terms.
	 	 	 
	 	15.8	Aggregation
    of Shares. All shares of Registrable Securities held or acquired by Permitted
    Transferees shall be aggregated together for the purpose of determining the availability
    of any rights under this Agreement.

[Remaining
of page was left intentionally blank]

    	15

    	 

    

    

In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	/s/ Mitchell Shivran	 	By:	 
	 	Title:	Mitchell Shivran-CEO MacroCure Ltd	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax
    (Israel) II – 
    Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

    	 

    	 

    

In Witness
Whereof, the parties hereto have caused this Agreement to be duly executed on the
day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	/s/ Jonathan Kolber
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	Jonathan Kolber
	 	Title:	 	 	Title:	Partner
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

 

    	 

    	 

    

In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	/s/ Illegible	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	/s/ Illegible	 	By:	 
	 	Title: 	Y.E.R.H. International Ltd.	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

    	 

    	 

    

In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	/s/ Illegible
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	/s/ Illegible	 	By:	/s/ Illegible
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

    	 

    	 

    

    In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	/s/ Barbara W Goldman	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 Barbara W Goldman	 	By:	 
	 	Title:	Partner	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

    	 

    	 

    
     

In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	/s/ Illegible
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

    	 

    	 

    

In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	/s/ Yitzhak Goldman	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

 

    	 

    	 

    

In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	/s/ Yair Aloni
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

 

    	 

    	 

    

In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed
on the day and year first above written:

	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Macrocure Ltd.	 	Viola Private Equity I, L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Vaizra Ventures Ltd.	 	Pontifax (Cayman) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 	Pontifax (Israel) II – Individual Investors L.P.	 	Pontifax (Israel) II L.P.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 
	 	Plan B Ventures I, LLC	 	Docor International B.V.
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 
	 	 	 	 
	 	Yitzhak Goldman	 	Yair Aloni
	 	 	 	 	 	 	 	 
	 	 	 	 
	 	dov shafir (as trustee for Michael Sela)	 	dov shafir (as trustee for Uriel Arnon)
	 	 	 	 	 	 	 	 
	 	/s/ Dov Shafir	 	/s/ Dov Shafir
	 	dov shafir	 	dov shafir (as trustee for yariv gilat)
	 	 	 	 	 	 	 	 
	 	/s/ Dov Shafir	 	/s/ Dov Shafir
	 	dov shafir (as trustee for H.M.L.K. Financial Consulting Services Ltd.)	 	Biosec Limited
	 	 	 	 	 	 	 	 
	 	By:	 	 	By:	 
	 	Title:	 	 	Title:	 
	 	 	 	 	 	 	 	 

    	 

    	 

    

SCHEDULE A 

INVESTORS

	 	 
	1.	Vaizra Ventures Ltd.
	2.	Viola Private Equity I, L.P.
	3.	Pontifax (Israel) II - Individual Investors L.P.
	4.	Pontifax (Israel) II L.P.
	5.	Pontifax (Cayman) II L.P.
	6.	Plan B Ventures I, LLC
	7.	Docor International B.V.
	8.	Biosec Limited
	9.	Yitzhak Goldman
	10.	Yair Aloni
	11.	Michael Sela
	12.	Uriel Arnon
	13.	Dov Shafir
	14.	Yariv Gilat
	15.	H.M.L.K Financial Consulting Services Ltd.

    	2Exhibit 10.1

 

English
Summary of Macrocure Ltd. 2008 Stock Option Plan (the “Plan”) (adopted by the Board of Directors (the
“Board”) of Macrocure Ltd. (the “Company”) on November 24, 2008).

 

		·	Purpose of Plan: To allocate options to the Company's employees, directors, advisors and service
providers in order to incentivize them and to allow them to share in the Company's development and success.

 

		·	Administration of Plan. The Plan is to be administered directly by the Board or, alternatively,
based on the advice of a compensation committee of the Board that shall consist of at least two members (the “Committee”).
In the event that the Board does not create a committee to administer the Plan, the Plan shall be administered by the Board in
its entirety. In the event that an action necessary for the administration of the Plan is required under law to be taken by the
Board, then such action shall be so taken by the Board. In the event that a Committee is not appointed or ceases to function, all
references herein to the Committee shall be construed as references to the Board.

 

		·	Authorities of Board and Committee Under Plan.

 

		o	The Committee has the authority to recommend, and the Board has the sole discretion to approve, the
following matters under the Plan: (1) who will be offered options and how many options will be offered; (2) the options' terms,
including exercise price and methods by which, and times at which, exercise may be made; (3) the fair market value of the shares
that underlie options; (4) the tax track of the options; and (5) the option type granted.

 

		o	The Committee has the sole authority and judgment to determine the following matters under the Plan,
including: (1) the limitations and terms that apply to options; (2) interpretation and oversight of the Plan (3) partial or complete
acceleration of the vesting applicable to any grantee; (4) suspension or cancellation, amendment or modification, of all or part
of the Plan; and (5) any other matter critical to the administration of the Plan.

 

		o	The Board has the authority to grant to an offeree, in exchange for the cancellation of his option,
a new option with the same or with a different exercise price and/or that is subject to other terms, different from the one cancelled.

 

		o	All decisions, determination and interpretations of the Committee shall be final and binding on all
grantees of any awards under the Plan, unless otherwise determined by the Board. No member of the Committee shall be liable for
any action taken or determination made in good faith with respect to the Plan or any award granted thereunder.

 

		·	Persons Eligible to Participate in the Plan. Individuals who are eligible to participate in
the plan include (1) employees of the Company and its affiliates (who are only eligible for options granted pursuant to the capital
gains tax route of Section 102 of the Israeli Tax Ordinance (the “Ordinance”)), (2) non- Company employees (who
are only eligible for options granted pursuant to Section 3(i) of the Ordinance), and (3) controlling shareholders of the Company
(who are only eligible for options granted pursuant to Section 3(i) of the Ordinance).

 

		·	Initial Pool of Shares Reserved for Issuance Under the Plan. The initial number of shares reserved
pursuant to the grant of awards under the Plan was 15,000 shares, all of which may be granted as incentive share options. Any
share that has not been issued and does not underlie an outstanding option on the date on which Plan expires will no longer be
reserved for purposes of the Plan. Any share underlying an option that is not exercised or that is cancelled returns to the pool
of shares available for future grant under the Plan.

 

		·	Exercise Price.

 

		o	The exercise price of an option shall be determined by the Board at its sole discretion based on guidelines
set by the Committee from time to time. Each option agreement (by which an option is granted) shall state the exercise price.

 

		o	The exercise price and the number and/or type of shares issuable upon exercise shall be adjusted due
to a stock split (forward or reverse), stock dividend, recapitalization or similar adjustment affecting the outstanding share capital.

 

		o	The exercise price per share of any outstanding option that has not been exercised yet and has not
expired yet shall be reduced by the net amount payable on each share of the Company’s stock due to any dividend distributed
to the Company’s shareholders.

    	 

    	 

    

 

		·	Adjustments due to merger or other transactions and similar events.
In the event of a merger or consolidation of the Company, or a sale of all,
or substantially all, of the Company’s shares or assets or other transaction having a similar effect on the Company, then
without the consent of an option holder, the Board or its designated committee, as applicable, may but is not required to (i) cause
any outstanding award to be assumed or an equivalent award to be substituted by such successor corporation, or (ii) in case the
successor corporation refuses to assume or substitute the award (a) provide the grantee with the option to exercise the award as
to all or part of the shares (even a portion not then otherwise vested) or (b) cancel the options against payment in cash in an
amount determined by the Board or the Committee as fair in the circumstances. Notwithstanding the foregoing, the Board or the Committee
may upon such event amend or terminate the terms of any award, including conferring the right to purchase any other security or
asset that the Board shall deem, in good faith, appropriate.

 

		·	Conditions and Method of Option Exercise.

 

		o	An option may be exercised, as to any or all shares as to which the option has become exercisable,
by written notice delivered in person or by mail to the Company or to such other person as determined by the Committee.

 

		o	An option shall expire according to the terms of an option agreement or, in the case in which an option
agreement is silent, as follows:

 

		§	In the case of termination of employment/engagement without cause, 180 days after the date of termination.

 

		§	In the case of termination due to death or disability, twelve months after the event of death/disability.

 

		§	In the case of termination of employment/engagement for cause, immediately.

 

		·	Other Option Terms. Options and exercise rights are not transferable. For so long as a tax
trustee holds options or shares on behalf of a grantee, the options or shares are not transferable, except by way of will or inheritance.

 

		·	Term of Option Plan. The Plan will be in force for 10 years from the day on which it was adopted
by the Board.

 

		·	Additional Terms. The Plan further includes terms concerning
the following non-material matters, which have been omitted from this Summary:

 

		o	Establishment of tax route under Section 102 of the Ordinance

 

		o	Trustee for purposes of Section 102 option grants

 

		o	Amendment of Plan

 

		o	Applicable law

 

		o	Taxation

 

		o	Jurisdiction

 

		o	Multiple forms of option grant agreements under the Plan

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