Document:

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                                                                 Exhibit 10.28.5

                     HAZARDOUS MATERIALS INDEMNITY AGREEMENT

      THIS INDEMNITY AGREEMENT (the "Agreement") is entered into as of the 28th
day of December, 1998, by the undersigned (hereinafter referred to collectively
as the "Indemnitors"), in favor of Genzyme Corporation (the "Mortgagee") with
its main office at One Kendall Square, Cambridge, Massachusetts 02139.

      Reference is made to the following facts:

      A. The Indemnitors have entered into an Amended and Restated Reimbursement
Agreement dated as of the date hereof (as amended from time to time, the
"Reimbursement Agreement") pursuant to which the Mortgagee agreed, subject to
the terms and conditions set forth therein, to certain financial accommodations
to Genzyme Transgenics Corporation (the "Accommodations").

      B. As a condition to making the Accommodations, Mortgagee requires that
Indemnitors agree to indemnify and hold harmless Mortgagee from any
Environmental Claim, any Requirements of Environmental Law, and any violation of
any Environmental Permit, and all Costs (as the foregoing terms are defined in
Exhibit A hereto), in each case, relating to the Premises (as hereinafter
defined). Mortgagee would not make the Accommodations without this Agreement and
Indemnitors acknowledge and understand that this Agreement is a material
inducement for Mortgagee's agreement to make the Accommodations.

      C. One of the Indemnitors is the owner of each of the parcels described as
"Owned Properties" on the attached Exhibit B and is the tenant under certain
leases (the "Leases") listed on Exhibit B, which leases relate to occupancy of
certain real property described as "Leased Properties" on Exhibit B. The Owned
Properties and the Leased Properties are individually and collectively referred
to as the "Premises". The other Indemnitors are affiliates of such owners and
tenants.

      NOW, THEREFORE, in consideration of the Mortgagee's agreement to make the
Accommodations and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Indemnitors hereby covenant and
agree as follows:

      1. Hazardous Materials; Compliance with Requirements of Environmental Law.

            a. The Indemnitors represent and warrant that they have never
generated, stored (other than the lawful storage of heating oil in amounts
required for the heating of buildings located on the Premises, or other than the
handling of Hazardous Materials in the Indemnitors' ordinary course of business
in compliance with the Requirements of Environmental Law), or disposed of any
Hazardous Materials on the Premises or any other property owned, occupied or
operated by the Indemnitors or any person for whose conduct the Indemnitors are
responsible, that, except as previously disclosed in writing to the Mortgagee,
the Indemnitors are not aware of the generation, storage, disposal or release of
Hazardous Materials on the Premises by anyone else, and that the Indemnitors are
not aware of the generation, storage, disposal or release of Hazardous Materials
upon or into the real property adjoining or in the vicinity of the Premises
which through soil or ground water migration could have come to be located at
the Premises. The Indemnitors further represent and warrant that, except as
previously disclosed in
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writing to the Mortgagee, there are no existing or closed underground storage
tanks on the Premises. The Indemnitors agree not to release or dispose of any
Hazardous Materials at the Premises, nor to permit same, at any time.

            b. The Indemnitors represent and warrant that the Premises complies
and that the Premises and the Indemnitors shall comply with all Requirements of
Environmental Law. The Indemnitors covenant to immediately notify the Mortgagee
of the presence, release or threat of release of any Hazardous Materials at or
from the Premises or any other property owned, occupied or operated by the
Indemnitors or any person for whose conduct the Indemnitors are responsible or
of any notice or claim received by it of any violation of any Requirements of
Environmental Law.

            c. The Mortgagee may (but shall not be obligated to), from time to
time, for reasonable cause, and at the Indemnitors' expense, conduct such
investigations as the Mortgagee deems reasonable to determine whether Hazardous
Materials exist on any part of the Premises and to determine the source,
quantity and type of such Hazardous Materials, if any, and the Indemnitors shall
cooperate with the Mortgagee in conducting such investigations. Such
investigations may include without limitation a detailed visual inspection of
the Premises, including all storage areas, storage tanks, drains and dry wells,
as well as the taking of soil samples, surface water samples, and ground water
samples and such other investigations or analyses as are necessary or
appropriate in the Mortgagee's sole discretion for a complete assessment of the
compliance of the Premises and the use and operation thereof with all
Requirements of Environmental Law. The Mortgagee and its officers, employees,
agents and contractors shall have and are hereby granted the right to enter upon
the Premises for the foregoing purposes, provided that the Mortgagee shall use
reasonable efforts to minimize the disruption to the operation of the
Indemnitors' business on the Premises.

            d. Without limiting the generality of this Section, the Indemnitors,
and the Premises and all alterations thereof, shall comply with all local, state
and federal laws and regulations now or hereafter in effect and applicable
relating to the presence, abatement, removal, disposal, transportation or
treatment of materials containing asbestos.

            e. Without limiting the generality of this Section, if any portion
of the Premises is to be used for residential purposes, the Premises and all
alterations thereof shall comply with all local, state and federal laws and
regulations now or hereafter in effect and applicable relating to the presence,
abatement, removal, disposal, transportation or treatment of materials
containing lead paint.

      2. Indemnification.

            a. Indemnitors shall protect, defend, indemnify, and hold harmless
Mortgagee, its officers, directors, shareholders, agents, employees, parents,
subsidiaries and affiliates and their respective heirs, legal representatives,
successors and assigns (Mortgagee and all such other persons and entities being
referred to herein individually as an "Indemnitee" and collectively as
"Indemnitees") from and against all Costs which at any time may be imposed upon
the Premises, the Indemnitees, or any of them, arising out of or in connection
with (i) Requirements of Environmental Law; (ii) Environmental Claims; (iii) the
failure of Indemnitors,

                                       2
<PAGE>

or any other party directly or indirectly connected with the Premises, or
affiliated with Indemnitors having any control over or responsibility for the
use and operation of the Premises, to obtain, maintain, or comply with any
Environmental Permit; and/or (iv) the presence, existence or threat of release
of Hazardous Materials (as defined in Exhibit A hereto) at, on, about, under,
within or in connection with the Premises.

            b. In the event that any Remedial Work (as defined in Exhibit A
hereto) is necessary under any applicable local, state or federal law or
regulation, any judicial order, or by any governmental or non-governmental
entity or person because of, or in connection with, the current or future
presence, suspected presence, release or suspected release or threat of release
of Hazardous Materials in or into the air, soil, ground water, surface water or
soil vapor at, on, about, under, within, near, from or in connection with the
Premises (or any portion thereof), Indemnitors shall promptly commence, or cause
to be commenced, and thereafter diligently prosecute to completion, all such
Remedial Work. All Remedial Work shall be performed by licensed contractors
qualified to perform such work under applicable federal, state and local law.
All Costs related to such Remedial Work shall be paid by Indemnitors including,
without limitation, reasonable Costs incurred by any Indemnitee in connection
with the monitoring or review of such Remedial Work by the Indemnitee or a third
party engaged by Indemnitee. In the event Indemnitors shall fail to promptly
commence, or cause to be commenced, or fail to diligently prosecute to
completion, such Remedial Work, Mortgagee may, but shall not be required to,
cause such Remedial Work to be performed and all Costs shall become an
Environmental Claim hereunder.

            c. This Agreement, and all rights and obligations hereunder shall
survive (i) repayment of the Accommodations; (ii) satisfaction, assignment or
reconveyance of the Mortgages by which the Premises secure the Indemnitor's
obligations under the Reimbursement Agreement (collectively, the "Mortgages"),
and release of other security provided in connection with the Accommodations;
(iii) foreclosure of the Mortgages and other security instruments in connection
with the Accommodations; (iv) acquisition of the Premises by Mortgagee by
deed-in-lieu of foreclosure or otherwise; (v) sale, assignment or transfer of
all or any portion of Mortgagee's rights in the Accommodations and the Premises
and (vi) termination of any of the Leases.

            d. Nothing contained in this Agreement shall prevent or in any way
diminish or interfere with any rights or remedies, including, without
limitation, the right to contribution, which any Indemnitee may have against
Indemnitors or any other party under the Comprehensive Environmental Response,
Compensation and Liability Act of 1980 (codified at Title 42 U.S.C. ss. 9601 et
seq.), as it may be amended from time to time, or any other applicable federal,
state or local laws, all such rights being hereby expressly reserved.

      3. Notice of Actions.

            a. Indemnitors shall give immediate written notice to Mortgagee of:
(i) its use, manufacture, production, handling or storage of any type of
Hazardous Material at the Premises, not previously disclosed to Mortgagee, or
any substantial increase in the quantity or magnitude of the use, manufacturing,
production, handling or storage of any type of Hazardous Material at the
Premises above levels previously disclosed to Mortgagee; (ii) any proceeding,

                                       3
<PAGE>

inquiry, notice, or other communication to it or of which it has knowledge, or
with the exercise of due diligence, should have had knowledge by or from any
governmental or non-governmental entity regarding the presence or suspected
presence of any Hazardous Material at, on, about, under, within or in connection
with the Premises or any migration thereof from or to the Premises; (iii) any
actual or alleged violation of any Requirements of Environmental Law; (iv) all
Environmental Claims; (v) the discovery of any occurrence or condition on any
real property adjoining or in the vicinity of the Premises that could cause the
Premises or any part thereof to be subject to any restrictions on ownership,
occupancy, transferability, or use, or subject the owner or any person having
any interest in the Premises to any liability, penalty, or disability under any
Requirements of Environmental Law; and (vi) the receipt of any notice or
discovery of any information regarding any actual, alleged, or potential
spillage, seepage, release, discharge, disposal or any other presence or
existence of any Hazardous Material at, on, about, under, within, near or in
connection with the Premises.

            b. Immediately upon receipt of the same, Indemnitors shall deliver
to Mortgagee copies of any and all Environmental Claims, and any and all orders,
notices, permits, applications, reports, and other communications, documents,
and instruments pertaining to the actual, alleged, or potential presence or
existence of any Hazardous Material at, on, about, under, within, near or in
connection with the Premises.

      4. Procedures Relating to Indemnification.

            a. In any circumstance in which this Agreement applies, Mortgagee
may, but shall not be obligated to, employ its own legal counsel and consultants
to investigate, prosecute, negotiate, or defend any such Environmental Claim and
in the event liability is asserted directly against Mortgagee, Mortgagee shall
have the right to compromise or settle such claim of liability against Mortgagee
without the consent of Indemnitors. Indemnitors shall reimburse Mortgagee,
within fifteen (15) days of demand, for all Costs incurred by Mortgagee,
including the amount of all Costs of settlements entered into by Mortgagee.

            b. Indemnitors shall not, without the prior written consent of
Mortgagee (i) settle or compromise any action, suit, proceeding, or claim or
consent to the entry of any judgment that does not include as an unconditional
term thereof the delivery by the claimant or plaintiff to Mortgagee of (x) a
full and complete written release of Mortgagee (in form, scope and substance
satisfactory to Mortgagee in its reasonable discretion) from all liability in
respect of such action, suit or proceeding and (y) a dismissal with prejudice of
such suit, action or proceeding; or (ii) settle or compromise any action, suit,
proceeding, or claim in any manner that may adversely affect Mortgagee as
determined by Mortgagee in its reasonable discretion.

      5. Binding Effect. This Agreement shall be binding upon the Indemnitors,
their successors and permitted assigns and shall inure to the benefit of the
Indemnitee and its successors and assigns, including as to Mortgagee, without
limitation, any affiliate of Mortgagee which acquires all or part of the
Premises by any sale, assignment, deed in lieu of foreclosure, foreclosure under
the Mortgages, or otherwise. The obligations of Indemnitors under this Agreement
shall not be assigned without the prior written consent of Mortgagee, which
consent may be given or withheld in the sole discretion of Mortgagee.

                                       4
<PAGE>

      6. Liability of Indemnitors. The liability of each party comprising the
Indemnitors shall be joint and several. The liability of Indemnitors under this
Agreement shall in no way be limited or impaired by the provisions of the
Mortgages or any of the other Accommodations Documents, or any amendment,
modification, extension or renewal thereof. No delay on the Mortgagee's part in
acting under this Indemnity shall operate as a waiver of any of the Mortgagee's
rights hereunder. No waiver hereunder by the Mortgagee in any instance shall
constitute a waiver in any other instance.

      7. Waiver. Indemnitors waive any right or claim of right to cause a
marshalling of the assets of Indemnitors or to cause Mortgagee to proceed
against any of the security for the Accommodations before proceeding under this
Agreement against Indemnitors; Indemnitors agree that any payments required to
be made hereunder shall become due on demand; to the extent permitted by
applicable law, Indemnitors expressly agree that the liability of the
Indemnitors hereunder shall in no way be affected by: (a) the release or
discharge of any Indemnitor in any creditors', receivership, bankruptcy or other
proceedings; (b) the impairment, limitation or modification of the liability of
any Indemnitor or the estate of the Indemnitor in bankruptcy, or of any remedy
for the enforcement of any Indemnitor's liability under the Accommodations
Documents, resulting from the operation of any present or future provision of
the Bankruptcy Code, 11 U.S.C. ss. 101 et seq. or other similar statute or from
the decision in any court; (c) the rejection or disaffirmance of the
Accommodations Documents in any such proceedings; (d) the assignment or transfer
of the Accommodations Documents by the Indemnitors; (e) any disability or other
defense of any Indemnitor; or (f) the cessation from any cause whatsoever for
the liability of any Indemnitor. Without limiting the generality of the
foregoing, the Indemnitors hereby waive all suretyship defenses or defenses in
the nature thereof.

      8. Notices. All notices, consents, approvals, elections and other
communications (collectively "Notices") hereunder shall be in writing (whether
or not the other provisions of this Agreement expressly so provide) and shall be
deemed to have been duly given if delivered in accordance with the terms of the
Reimbursement Agreement.

      9. Attorneys' Fees. In the event that any Indemnitee brings or otherwise
becomes a party to any suit or other proceeding (including, without limitation,
any administrative proceedings, but excluding any suit brought by any Indemnitee
which is ruled to be frivolous or brought in bad faith) with respect to the
subject matter or enforcement of this Agreement, such Indemnitee shall, in
addition to such other relief as may be awarded, be entitled to recover from
Indemnitors attorneys' fees, expenses and costs of investigation as are actually
incurred (including, without limitation, reasonable attorneys' fees, expenses
and costs of investigation incurred in appellate proceedings, costs incurred in
establishing the right to indemnification, or in any action or participation in,
or in connection with, any case or proceeding under Chapter 7, 11 or 13 of the
Bankruptcy Code, 11 U.S.C.ss.101 et seq., or any successor statutes).

      10. Governing Law. This Agreement and the rights and obligations of the
parties hereunder shall in all respects be governed by, and construed and
enforced in accordance with, the laws of the Commonwealth of Massachusetts
("State"). Indemnitors hereby irrevocably submit to the non-exclusive
jurisdiction of any State or federal court sitting in Boston, Massachusetts over
any suit, action or proceeding arising out of or relating to this Agreement, and
Indemnitors hereby agree and consent that, in addition to any other methods of
service of

                                       5
<PAGE>

process in any such suit, action or proceeding in any State or federal court
sitting in Boston, Massachusetts, service of process may be made by certified or
registered mail, return receipt requested, directed to Indemnitors at the
address indicated in Section 7 hereof, and service so made shall be complete one
(1) day after the same shall have been so mailed.

      11. Successive Actions. A separate right of action hereunder shall arise
each time Mortgagee acquires knowledge of any matter indemnified by Indemnitors
under this Agreement. Separate and successive actions may be brought hereunder
to enforce any of the provisions hereof at any time and from time to time. No
action hereunder shall preclude any subsequent action, and Indemnitors hereby
waive and covenant not to assert any defense in the nature of splitting of
causes of action or merger of judgments.

      12. Partial Invalidity. If any provision of this Agreement shall be
determined to be unenforceable in any circumstances by a court of competent
jurisdiction, then the balance of this Agreement shall be enforceable
nonetheless, and the subject provision shall be enforceable in all other
circumstances.

      13. Interest on Unpaid Amounts. All amounts required to be paid or
reimbursed to any Indemnitee hereunder shall bear interest from the date of
expenditure by such Indemnitee or the date of written demand to Indemnitors
hereunder, whichever is later, until paid to Indemnitee(s). The interest rate
shall be the lesser of (a) eighteen percent (18%) per annum or (b) the maximum
rate then permitted for the parties to contract for under applicable law.

      14. Authority. Each individual signing this Indemnity Agreement on behalf
of the Indemnitors or any other indemnitor which is not a natural person
warrants and represents to the Mortgagee that he or she is authorized to do so
by all requisite action of the Indemnitors or such other entity.

      15. Exhibits. All exhibits attached hereto are incorporated by reference.

                                       6
<PAGE>

      IN WITNESS WHEREOF, Indemnitors have executed this Agreement as of the
date first set forth above.

                                  GENZYME TRANSGENICS CORPORATION

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  GTC CANCER VACCINES, INC.

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  TSI CORPORATION

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  GENZYME TRANSGENICS SECURITIES CORPORATION

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  PRIMEDICA CORPORATION (formerly TSI
                                  Holdings, Inc.)

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  PRIMEDICA CAMBRIDGE, INC. (formerly
                                  BioDevelopment Laboratories, Inc.)

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

<PAGE>

                                  PRIMEDICA ROCKVILLE, INC. (formerly TSI
                                  Washington Laboratories, Inc.)

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  PRIMEDICA REDFIELD, INC. (formerly TSI
                                  Redfield Laboratories, Inc.)

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  PRIMEDICA WORCESTER, INC., (formerly TSI Mason
                                  Laboratories, Inc.)

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  PRIMEDICA ARGUS RESEARCH LABORATORIES, INC.
                                  (formerly Argus Research Laboratories, Inc.)

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

                                  TRANSGENICS INVESTMENTS, INC.

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

<PAGE>

                                  HEALTH SCIENCES RESEARCH INCORPORATED

                                  By: /s/ John B. Green
                                     -------------------------------------------
                                     John B. Green
                                     Vice President and Chief Financial Officer

<PAGE>

Exhibits:   A - Definitions
            B - Premises Description:     Owned Properties
                          Leased Properties
                          Leases

<PAGE>

                          COMMONWEALTH OF MASSACHUSETTS
County of Suffolk, ss:                                         December __, 1998

      Then personally appeared the above named John B. Green, as Vice President
of each of the corporations set out above, and acknowledged the foregoing
instrument to be his free act and deed as Vice President of said corporations,
before me,

                              ------------------------------------
                              Notary Public
                              My commission expires:

<PAGE>

                                    EXHIBIT A

                                   DEFINITIONS

      Definitions. For purposes of this Agreement, the following terms shall
have the following meanings:

      (a) "Costs" shall mean all liabilities, losses, costs, damages, (including
consequential damages), expenses, claims, attorneys' fees, experts' fees,
consultants' fees and disbursements of any kind or of any nature whatsoever. For
the purposes of this definition, such losses, costs and damages shall include,
without limitation, remedial, removal, response, abatement, restoration,
cleanup, legal, investigative and monitoring costs and related costs, expenses,
losses, damages, penalties, fines, obligations, defenses, judgments, suits,
proceedings and disbursements. Costs shall also include, without limitation, (i)
the costs of removal, transportation and disposal of any and all Hazardous
Materials from all or any portion of the Premises, (ii) costs required to take
necessary precautions to protect against the release of Hazardous Materials at,
on, in, about, under, within, near or in connection with the Premises in or into
the air, soil, surface water, ground water, or soil vapor, any public domain, or
any surrounding areas, and (iii) costs incurred to comply, in connection with
all or any portion of the Premises, with all applicable laws with respect to
Hazardous Materials, including any such laws applicable to the work referred to
in this sentence.

      (b) "Environmental Claim" shall include, but not be limited to, any claim,
demand, action, cause of action, suit, loss, cost, damage, fine, penalty,
expense, liability, judgment, proceeding, or injury, whether threatened, sought,
brought, or imposed, that seeks to impose costs or liabilities for the
following, occurring at, on, about under, within, near, from, or in connection
with the Premises: (i) noise; (ii) pollution or contamination of the air,
surface water, ground water, or soil; (iii) solid, gaseous, or liquid waste
generation, handling, treatment, storage, disposal, or transportation; (iv)
exposure to Hazardous Materials; (v) the manufacture, processing, distribution
in commerce, use, or storage of Hazardous Materials; (vi) injury to or death of
any person or persons arising out of the discharge, release, storage, handling,
presence, or transport of Hazardous Materials; (viii) any and all penalties
arising out of the discharge, release, storage, handling, presence, or transport
of Hazardous Materials, (ix) any assertion of breach or violation of any
Requirements of Environmental Law, or any event, occurrence, or condition
relating to the Premises as a consequence of which (A) Indemnitors, Mortgagee,
or any owner, occupant, or person having any interest in the Premises shall be
liable, or (B) the Premises shall be subject to any restriction on use,
ownership, transferability, or (iii) any Remedial Work shall be required.

      (c) "Environmental Permit" means any permit, license, approval, or other
authorization with respect to any activities, operations, or businesses
conducted on or in relation to the Premises under any applicable law,
regulation, or other requirement of the United States or any state,
municipality, or other subdivision or jurisdiction related to pollution or
protection of health or the environment, or any private agreement (such as
covenants, conditions and restrictions), including laws, regulations or other
requirements relating to emissions, discharges, or releases or threatened
releases of Hazardous Materials into ambient air, surface water, ground water,
or soil, or otherwise relating to the manufacture, processing, distribution,
use, generation,

<PAGE>

treatment, storage, disposal, transportation, or handling of Hazardous Materials
at, on, about, under, within, near, or from the Premises.

      (d) "Hazardous Materials" shall include the following:

            (i) Those substances included within the definitions of "hazardous
substances," "hazardous materials," "toxic substances," or "solid waste" in the
Comprehensive Environmental Response Compensation and Liability Act of 1980 (42
U.S.C.ss. 9601 et seq.) ("CERCLA"), as amended by Superfund Amendments and
Reauthorization Act of 1986 (Pub. L. 99-499 100 Stat. 1613) ("SARA"), the
Resource Conservation and Recovery Act of 1976 (42 U.S.C.ss. 6901 et seq.)
("RCRA"), the Toxic Substance Control Act of 1976 ("TSCA"), and the Hazardous
Materials Transportation Act, 49 U.S.C.ss.1801 et seq., and in the regulations
promulgated pursuant to said laws, all as amended;

            (ii) Those substances listed in the United States Department of
Transportation Table (49 CFR 172.101 and amendments thereto) or by the
Environmental Protection Agency (or any successor agency) as hazardous
substances (40 CFR Part 302 and amendments thereto);

            (iii) Any material, waste or substance which is (A) petroleum, (B)
asbestos, (C) polychlorinated biphenyls, (D) designated as a "hazardous
substance" pursuant to Section 311 of the Clean Water Act, 33 U.S.C.ss. 1251 et
seq. (33 U.S.C.ss. 1321) or listed pursuant to Section 307 of the Clean Water
Act (33 U.S.C.ss. 1317); (E) flammable explosives; or (F) radioactive materials;

            (iv) Asbestos;

            (v) Lead paint; and

            (vi) Such other substances, materials and wastes which are or become
regulated as hazardous or toxic under applicable local, state or federal law, or
the United States government, or which are classified as hazardous or toxic
under federal, state, or local laws or regulations.

      (e) "Remedial Work" shall mean any investigation, site monitoring,
containment, clean-up, removal, transportation, disposal, restoration,
reporting, or sampling with respect to Hazardous Materials or soil, water,
tanks, drums or other materials which contain or contained Hazardous Materials.

      (f) "Requirements of Environmental Law" means all requirements of
environmental or ecological laws or regulations or controls which are applicable
to the Premises or the activities conducted thereon, including all requirements
imposed by any law, rule, order, or regulations of any federal, state, or local
executive, legislative, judicial, regulatory, or administrative agency, board,
or authority, or any private agreement (such as covenants, conditions and
restrictions), which relate to (i) noise; (ii) pollution or protection of the
air, surface water, ground water, or soil; (iii) solid, gaseous, or liquid waste
generation, treatment, storage, disposal, or transportation; (iv) exposure to
Hazardous Materials; or (v) regulation of the manufacture, processing,
distribution and commerce, use, or storage of Hazardous Materials.

<PAGE>

                                    EXHIBIT B

                              PREMISES DESCRIPTION

Owned Properties:

1.

Leased Properties and Leases:<PAGE>

                                                                 Exhibit 10.32.2

                   FIRST AMENDMENT TO INTERCREDITOR AGREEMENT

      This FIRST AMENDMENT TO INTERCREDITOR AGREEMENT dated as of December 28,
1998 (this "Amendment") is among Genzyme Corporation (the "Senior Creditor"), a
Massachusetts corporation; Genzyme Transgenics Corporation ("GTC"), a
Massachusetts corporation; the Subsidiaries of GTC listed on the signature pages
hereto (each of GTC and such Subsidiaries, a "Borrower" and collectively such
Subsidiaries with GTC, the "Borrowers"); and FINOVA Technology Finance, Inc.
(formerly known as Financing for Science International, Inc., the "Subordinating
Creditor"), a Delaware corporation.

      WHEREAS, the parties previously entered into an Intercreditor Agreement
dated as of July 3, 1995 (the "Original Intercreditor Agreement") providing for
certain subordination of the rights of the Subordinating Creditor pursuant to
the Original Intercreditor Agreement to the rights of Genzyme pursuant to the
Reimbursement Agreement dated as of July 3, 1995 among the Senior Creditor, the
Borrowers, and the Subordinated Creditor; and

      WHEREAS, GTC is entering into a new Credit Agreement dated as of the date
hereof with Fleet National Bank ("Fleet") to refinance the indebtedness under
its agreements with BankBoston, N.A. (formerly The First National Bank of
Boston); and

      WHEREAS, the parties wish to amend the Original Intercreditor Agreement to
reflect amendments to the documents constituting Senior Debt;

NOW, THEREFORE, in consideration of the foregoing and the agreements contained
herein, the parties hereby agree as follows. Terms used herein and not otherwise
defined shall have the meanings assigned to them in the Original Intercreditor
Agreement.

      1. Amendment to the Original Intercreditor Agreement. The Original
Intercreditor Agreement is amended as follows:

      (a) Amendment to Recitals. Each of the recitals is hereby deleted in its
entirety and replaced by the following:

            WHEREAS, pursuant to a Credit Agreement dated as of December ___,
      1998 (as amended and in effect from time to time, the "GTC Credit
      Agreement"), Fleet National Bank (the "Bank") agreed, upon the terms and
      subject to the conditions contained therein, to make loans to GTC; and

            WHEREAS, pursuant to a Master Equipment Lease Agreement (together
      with rental schedules thereto, the "Lease Agreement"), certain Sale and
      Leaseback Agreements (collectively, together with the Lease Agreement, the
      "FSI Lease Agreements") and a Security Agreement (the "Subordinated
      Agreement"), each dated September 27, 1994 between the Subordinating
      Creditor and TSI, the Subordinating Creditor leased certain equipment
      listed in Exhibit A hereto (as defined in the FSI Lease Agreement, the
      "Equipment") to TSI; and

<PAGE>

            WHEREAS, certain subsidiaries of TSI, namely Primedica Argus
      Research Laboratories, Inc., Primedica Worcester, Inc., Primedica
      Redfield, Inc., Primedica Rockville, Inc., and Health and Sciences
      Research Incorporated (collectively, the "Significant Subsidiaries"), each
      entered into a Guaranty of Lease (a "Subsidiary Guaranty") dated as of
      September 27, 1994 providing for the guarantee by such Significant
      Subsidiaries of the obligations of TSI to the Subordinating Creditor under
      the FSI Lease Agreement and the Subordinated Agreement; and

            WHEREAS, GTC entered into a Subsidiary Guaranty dated December 26,
      1996 providing for the guarantee by GTC of the obligations of TSI to the
      Subordinating Creditor under the Subordinating Creditor Lease Agreements
      and the Subordinated Agreement; and

            WHEREAS, GTC and certain of the Significant Subsidiaries, namely
      Primedica Argus Research Laboratories, Inc., Primedica Worcester, Inc. and
      Primedica Rockville, Inc., each entered into an additional Guaranty of
      Lease dated June 30, 1995 (each also a "Subsidiary Guaranty") providing
      for the guarantee by such Significant Subsidiaries of the obligations of
      TSI to the Subordinating Creditor under rental schedules pursuant to the
      Lease Agreement; and

            WHEREAS, GTC, TSI and the Subordinating Creditor previously entered
      into a Subordination Agreement dated as of September 27, 1994 providing
      for certain subordination of the rights of FSI pursuant to the
      Subordinated Agreement to the rights of a prior lender to GTC (the
      "Original Subordination Agreement"); and

            WHEREAS, the Obligations (as defined in the GTC Credit Agreement) of
      GTC shall be guarantied pursuant to that certain Guaranty dated as of the
      date hereof by the Senior Creditor in favor of the Bank (the "Guaranty");
      and

            WHEREAS, the reimbursement obligations of GTC pursuant to the
      Guaranty are described in the Amended and Restated Reimbursement Agreement
      dated as of the date hereof (the "Amended and Restated Reimbursement
      Agreement") among the Senior Creditor and the Borrowers; and

            WHEREAS, to secure the obligation of GTC and its subsidiaries to
      reimburse the Senior Creditor for any payments under the Guaranty and the
      Amended and Restated Reimbursement Agreement, GTC and its subsidiaries
      have entered into an Amended and Restated Security Agreement dated as of
      the date hereof in favor of the Senior Creditor and GTC has also entered
      into a Mortgage and Security Agreement in favor of the Senior Creditor, as
      amended (the "GTC Security Agreements"); and

            WHEREAS, it is a condition precedent to the Senior Creditor's
      willingness to provide the Guaranty that GTC, its subsidiaries and the
      Subordinating Creditor enter into this Agreement with the Senior Creditor;

      (b) Amendment to Definition of Senior Debt. The definition of "Senior
Debt" in Section 1 is hereby deleted in its entirety and replaced by the
following:

                                       2
<PAGE>

            Senior Debt. All principal, interest, fees, costs, enforcement
      expenses (including legal fees and disbursements), collateral protection
      expenses and other reimbursement or indemnity obligations created or
      arising under the Guaranty, the Amended and Restated Reimbursement
      Agreement, the GTC Security Agreements or any of the other documents
      related thereto as the foregoing may be amended from time to time or any
      prior, concurrent, or subsequent notes, instruments or agreements of
      indebtedness, liabilities or obligations of any type or form whatsoever
      relating thereto in favor of the Senior Creditor. Senior Debt shall
      expressly include any and all interest accruing or out-of-pocket costs or
      expenses incurred after the date of any filing by or against any Borrower
      or Borrowers of any petition under the federal Bankruptcy Code or any
      other bankruptcy, insolvency, or reorganization act regardless of whether
      the Senior Creditor's claim(s) therefor is allowed or allowable in the
      case or proceeding relating thereto.

      2. Miscellaneous.

      (a) Except to the extent specifically amended hereby, the Intercreditor
Agreement and all related documents shall remain in full force and effect.
Whenever the terms or sections amended hereby shall be referred to in the
Intercreditor Agreement or such other documents (whether directly or by
incorporation into other defined terms), such defined terms shall be deemed to
refer to those terms or sections as amended by this Amendment.

      (b) This Amendment may be executed in any number of counterparts, each of
which, when executed and delivered, shall be an original, but all counterparts
shall together constitute one instrument.

      (c) This Amendment shall be governed by the laws of the Commonwealth of
Massachusetts and shall be binding upon and inure to the benefit of the parties
hereto and their respective successors and assigns.

                                       3
<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Amendment which shall
be deemed to be a sealed instrument as of the date first above written.

                                   GENZYME CORPORATION

                                   By:
                                      -----------------------------------------
                                      Evan Lebson
                                      Treasurer

                                   FINOVA TECHNOLOGY FINANCE, INC.

                                   By: /s/ Linda A. Moschitto
                                      -----------------------------------------
                                      Linda A. Moschitto
                                      Director - Contract Administration

                                   GENZYME TRANSGENICS CORPORATION

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   TSI CORPORATION

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   PRIMEDICA CAMBRIDGE, INC. (formerly
                                   BioDevelopment Laboratories, Inc.)

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   PRIMEDICA ROCKVILLE, INC. (formerly TSI
                                   Washington Laboratories, Inc.)

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                      2
<PAGE>

                                   PRIMEDICA REDFIELD, INC. (formerly TSI
                                   Redfield Laboratories, Inc.)

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   PRIMEDICA WORCESTER, INC., (formerly
                                   TSI Mason Laboratories, Inc.)

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   PRIMEDICA ARGUS RESEARCH LABORATORIES, INC.
                                   (formerly Argus Research Laboratories, Inc.)

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   TRANSGENICS INVESTMENTS, INC.

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   HEALTH SCIENCES RESEARCH INCORPORATED

                                   By: /s/ John B. Green
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                       3
<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Amendment which shall
be deemed to be a sealed instrument as of the date first above written.

                                   GENZYME CORPORATION

                                   By: /s/ Evan M. Lebson
                                      -----------------------------------------
                                      Evan Lebson
                                      Treasurer

                                   FINOVA TECHNOLOGY FINANCE, INC.

                                   By:
                                      -----------------------------------------
                                      Name:
                                      Title:

                                   GENZYME TRANSGENICS CORPORATION

                                   By:
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   TSI CORPORATION

                                   By:
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   PRIMEDICA CAMBRIDGE, INC. (formerly
                                   BioDevelopment Laboratories, Inc.)

                                   By:
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                   PRIMEDICA ROCKVILLE, INC. (formerly TSI
                                   Washington Laboratories, Inc.)

                                   By:
                                      -----------------------------------------
                                      John B. Green
                                      Vice President and Chief Financial Officer

                                      2

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