Document:

Amended and Restated 1997 Employee Stock Purchase Plan

 Exhibit 10.49 
 KLA-TENCOR CORPORATION 
 AMENDED AND RESTATED 1997
EMPLOYEE STOCK PURCHASE PLAN 
 (as amended and restated as of November 17, 1998 
 and as subsequently amended to date (December 7, 2009)) 
 The following constitute the provisions of the 1997 Employee Stock Purchase Plan, as amended (the “Plan”), of KLA-Tencor Corporation (the “Company”). Certain definitions of terms used
in the Plan are provided in Section 2 below. This amended and restated version of the Plan, approved by the Company’s Board of Directors on December 7, 2009, is effective for Offering Periods commencing on or after January 1,
2010. 
  

	1.	PURPOSE 

 The purpose of the Plan
is to provide employees of the Company and its Designated Subsidiaries with an opportunity to purchase Common Stock of the Company through accumulated payroll deductions (or other methods, to the extent permitted by the Board pursuant to
Section 6(a) below). It is the Company’s intention that the Plan qualify as an “Employee Stock Purchase Plan” under Section 423 of the Code. The provisions of the Plan shall, accordingly, be construed so as to extend and
limit participation in a manner consistent with the requirements of that section of the Code. The Plan will also be extended to Employees of foreign Subsidiaries subject to adjustments, in the sole discretion of the Board of Directors, to take into
account the requirements of the local laws associated with the particular Subsidiary. These local requirements may not provide the same favorable tax consequences as are available to participants in the United States. 
  

	2.	DEFINITIONS 

 (a)
“BOARD” shall mean the Board of Directors of the Company. 
 (b) “CODE” shall mean the Internal Revenue Code
of 1986, as amended. 
 (c) “COMMON STOCK” shall mean the Common Stock, $.001 par value, of the Company. 

(d) “COMPANY” shall mean KLA-Tencor Corporation, a Delaware corporation. 
 (e) “COMPENSATION” shall mean all amounts includable as “wages” subject to tax under Section 3101(a) of the Code
without applying the dollar limitation of Section 3121(a) of the Code. Accordingly, Compensation shall include, without limitation, salaries, commissions, bonuses and overtime. Compensation shall not include reimbursements of expenses,
allowances, or any amount deemed received without the actual transfer of cash or any Company contributions or payments to any trust, fund, or plan to provide retirement, pension, profit sharing, health, welfare, death, insurance or similar benefits
to or on behalf of such Participant or any other payments not specifically referenced above, except to the extent that the inclusion of any such item with respect to all Participants on a nondiscriminatory basis is specifically approved by the
Board. 

 (f) “CONTINUOUS STATUS AS AN EMPLOYEE” shall mean the absence of any interruption
or termination of service as an Employee. Continuous Status as an Employee shall not be considered interrupted in the case of a leave of absence agreed to in writing by the Company, provided that such leave is for a period of not more than ninety
(90) days or re-employment upon the expiration of such leave is guaranteed by contract or statute. 
 (g) “DESIGNATED
SUBSIDIARIES” shall mean the Subsidiaries which have been designated by the Board from time to time in its sole discretion as eligible to participate in the Plan. 
 (h) “EMPLOYEE” shall mean any person, including an officer, who is customarily employed for at least 20 hours per week and more than five months in a calendar year by the Company or one of its
Designated Subsidiaries. 
 (i) “ENROLLMENT DATE” shall mean the first day of each Offering Period. 
 (j) “EXERCISE DATE” shall mean (i) June 30 of each year for each Offering Period that commences on January 1 and
(ii) December 31 of each year for each Offering Period that commences on July 1. 
 (k) “OFFERING
PERIOD” shall mean a period of six (6) months commencing on January 1 and July 1 of each year during which an option granted pursuant to the Plan may be exercised. 
 (l) “PLAN” shall mean this 1997 Employee Stock Purchase Plan. 
 (m) “SUBSIDIARY” shall mean a corporation, domestic or foreign, of which not less than fifty percent (50%) of the voting
shares are held by the Company or a Subsidiary, whether or not such corporation now exists or is hereafter organized or acquired by the Company or a Subsidiary. 
  

	3.	ELIGIBILITY 

 (a) Any Employee
who shall be employed by the Company or one of its Designated Subsidiaries on a given Enrollment Date and who has been so employed for at least 30 consecutive days immediately prior to such date shall be eligible to participate in the Plan, subject
to limitations imposed by Section 423(b) of the Code or other applicable local law. The Board, in its discretion, from time to time, may, prior to an Enrollment Date for all options to be granted on such Enrollment Date, determine (on a uniform
and nondiscriminatory basis) the Employees who will or will not be eligible to participate in the Plan consistent with Section 423(b)(4) of the Code. 
 (b) Any provisions of the Plan to the contrary notwithstanding, no Employee shall be granted an option under the Plan (i) if, immediately after the grant, such Employee (or any other person whose
stock would be attributed to such Employee pursuant to Section 424(d) of the Code) would own stock and/or hold outstanding options to purchase stock possessing five percent (5%) or more of the total combined voting power or value of all
classes of stock of the Company or of any 
  

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 Subsidiary, or (ii) which permits such Employee’s rights to purchase stock under all employee
stock purchase plans of the Company and its Subsidiaries to accrue at a rate which exceeds US$25,000 of fair market value of such stock (determined at the time such option is granted) for each calendar year in which such option is outstanding at any
time. 
  

	4.	OFFERING PERIODS 

 The Plan shall
be implemented by consecutive Offering Periods with a new Offering Period commencing on January 1 and July 1 of each year, or as otherwise determined by the Board, until the Plan is terminated in accordance with Section 19 hereof. The
Board shall have the power to change the duration of Offering Periods, not to exceed twenty-seven (27) months, with respect to future offerings without stockholder approval if such change is announced at least fifteen (15) days prior to
the scheduled beginning of the first Offering Period to be affected. 
  

	5.	PARTICIPATION 

 (a) An eligible
Employee may become a participant in the Plan by completing a subscription agreement authorizing payroll deductions on the form provided by the Company and filing it with the Company’s Plan administrator (or its designate) during the open
enrollment period prior to the applicable Enrollment Date, unless a later time for filing the subscription agreement is set by the Board for all eligible Employees with respect to a given Offering Period. 
 (b) Payroll deductions for a participant shall commence on the first payroll date following the Enrollment Date and shall end on the last
payroll date in the Offering Period to which such authorization is applicable, unless sooner terminated by the participant as provided in Section 10. 
  

	6.	PAYROLL DEDUCTIONS 

 (a) At the
time a participant files his subscription agreement, he shall elect to have payroll deductions made on each pay date during the Offering Period in an amount not exceeding ten percent (10%) of the Compensation which he receives on each pay date
during the Offering Period, and the aggregate of such payroll deductions during the Offering Period shall not exceed ten percent (10%) of his aggregate Compensation during said Offering Period. If the Board determines that payroll deductions
are not feasible in a particular country outside the United States, the Board may permit an eligible participant to participate in the Plan by an alternative means, such as by check; however, the rate of contributions may not exceed any whole number
percentage (as determined by the Board) of the participant’s aggregate Compensation up to ten percent (10%) (or such greater percentage, as specified by the Board) to apply to an Offering Period. 
 (b) All payroll deductions made by a participant shall be credited to his account under the Plan. A participant may not make any additional
payments into such account, except as provided under Section 6(a). 
 (c) The deduction rate so authorized shall continue
in effect for the entire Offering Period, unless the participant shall reduce such rate by filing the appropriate form with the Plan Administrator (or its designate). The reduced rate shall become effective as soon as practicable following the
filing of such form. 
  

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 (d) Notwithstanding the foregoing, to the extent necessary to comply with
Section 423(b)(8) of the Code and Section 3(b) herein, the Company may automatically decrease a participant’s payroll deductions to zero percent (0%) at such time during any Offering Period which is scheduled to end during the current
calendar year. Payroll deductions shall recommence at the rate provided in such participant’s subscription agreement at the beginning of the first Offering Period which is scheduled to end in the following calendar year, unless terminated by
the participant as provided in Section 10. 
  

	7.	GRANT OF OPTION 

 (a) On the
Enrollment Date of each Offering Period, each eligible Employee participating in such Offering Period shall be granted an option to purchase on the applicable Exercise Date for the Offering Period (at the per share option price) up to a number of
shares of the Company’s Common Stock determined by dividing such Employee’s payroll deductions accumulated during such Offering Period by eighty-five percent (85%) of the fair market value of a share of the Company’s Common Stock
on the Enrollment Date or on the Exercise Date, whichever is lower; provided that (i) the number of shares subject to the option shall not exceed two hundred percent (200%) of the number of shares determined by dividing ten percent
(10%) of the Employee’s Compensation over the Offering Period by eighty-five percent (85%) of the fair market value of a share of the Company’s Common Stock on the Enrollment Date and (ii) notwithstanding anything to the
contrary set forth herein, in no event will an eligible Employee be permitted to purchase during each Offering Period more than five thousand (5,000) shares of the Company’s Common Stock (subject to any adjustment pursuant to
Section 18), in each case subject to the limitations set forth in Sections 3(b) and 12 hereof. The Administrator may, for future Offering Periods, increase or decrease, in its absolute discretion, the maximum number of shares of the
Company’s Common Stock that an eligible Employee may purchase during each Offering Period. Fair market value of a share of the Company’s Common Stock shall be determined as provided in Section 7(b) herein. 
 (b) The option price per share of the shares offered in a given Offering Period shall be the lower of: (i) eighty-five percent
(85%) of the fair market value of a share of the Common Stock of the Company on the Enrollment Date; or (ii) eighty-five percent (85%) of the fair market value of a share of the Common Stock of the Company on the applicable Exercise
Date. The option price per share may be determined for subsequent Offering Periods by the Board subject to compliance with Section 423 of the Code (or any successor rule or provision or any other applicable law, regulation or stock exchange
rule) or pursuant to Section 19. The fair market value of the Company’s Common Stock on a given date shall be determined by the Board in its discretion; provided, however, that where there is a public market for the Common Stock, the fair
market value per share shall be the closing price of the Common Stock for such date, as reported by the Nasdaq National Market. If a closing price is not available for an Enrollment Date or an Exercise Date, the fair market value of a share of the
Common Stock of the Company on such date shall be the fair market value of a share of the Common Stock of the Company on the last business day prior to such date. 
  

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	8.	EXERCISE OF OPTION 

 Unless a
participant withdraws from the Plan as provided in Section 10, his option for the purchase of shares will be exercised automatically on each Exercise Date, and the maximum number of full shares subject to his option will be purchased for him at
the applicable option price with the accumulated payroll deductions in his account. During his lifetime, a participant’s option to purchase shares hereunder is exercisable only by him. Any amount remaining in the participant’s account
after an Exercise Date shall be refunded to the participant. 
  

	9.	DELIVERY 

 As promptly as
practicable after each Exercise Date, the Company shall arrange the delivery to each participant, as appropriate, of a certificate representing the shares (or electronic delivery of such shares) purchased upon exercise of his option. 
  

	10.	WITHDRAWAL; TERMINATION OF EMPLOYMENT 

 (a) A participant may withdraw all but not less than all of the payroll deductions credited to his account under the Plan at any time by giving written notice to the Company. All of the participant’s payroll deductions credited to his
account will be paid to him as soon as practicable after receipt of his notice of withdrawal and his participation in the Plan will be automatically terminated, and no further payroll deductions for the purchase of shares will be made. Payroll
deductions will not resume on behalf of a participant who has withdrawn from the Plan unless written notice is delivered to the Company within the open enrollment period preceding the commencement of an Offering Period directing the Company to
resume payroll deductions. 
 (b) Upon termination of the participant’s Continuous Status as an Employee prior to the
Exercise Date of an Offering Period for any reason, including retirement or death, the payroll deductions credited to the participant’s account will be returned to the participant or, in the case of death, to the person or persons entitled
thereto under Section 14, and such participant’s option will be automatically terminated. 
 (c) If an Employee fails
to maintain Continuous Status as an Employee for at least 20 hours per week during an Offering Period in which the Employee is a participant, he will be deemed to have elected to withdraw from the Plan and the payroll deductions credited to his
account will be returned to him and his option terminated. 
 (d) A participant’s withdrawal from an Offering Period will
not have any effect upon his eligibility to participate in a succeeding Offering Period or in any similar plan which may hereafter be adopted by the Company. 
  

	11.	INTEREST 

 No interest shall
accrue on the payroll deductions of a participant in the Plan. 
  

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	12.	STOCK 

 (a) Subject to adjustment
as provided in Section 18, the maximum aggregate number of shares of the Company’s Common Stock which shall be made available for sale under the Plan as of November 17, 1998 shall be 1,200,000, increased on the first day of each
fiscal year of the Company beginning on and after July 1, 1999 by a number of shares of the Company’s Common Stock equal to the lesser of (i) 2,000,000 shares, or (ii) the number of shares which the Company estimates (based on
the previous 12-month period) it will be required to issue under the Plan during the forthcoming fiscal year. Subject to adjustment as provided in Section 18, shares issuable under the Plan shall consist of authorized but unissued or reacquired
shares of the Company’s Common Stock or any combination thereof. If on a given Exercise Date the number of shares with respect to which options are to be exercised exceeds the number of shares then available, the Company shall make a pro rata
allocation of the shares remaining available for option grant in as uniform a manner as shall be practicable and as it shall determine to be equitable. In such event, the Company shall give written notice of such reduction of the number of shares
subject to the option to each Employee affected thereby and shall similarly reduce the rate of payroll deductions, if necessary. 
 (b) The participant will have no interest or voting right in shares covered by his option until such option has been exercised. 
 (c) Shares to be delivered to a participant under the Plan will be registered in the name of the participant or in the name of the participant and his or her spouse. 
  

	13.	ADMINISTRATION 

 The Plan shall
be administered by the Board of Directors of the Company or a committee appointed by the Board. The Board may delegate routine matters to management. The administration, interpretation or application of the Plan by the Board, its committee or their
respective delegates shall be final, conclusive and binding upon all participants. 
 Members of the Board who are eligible
Employees are permitted to participate in the Plan, provided that: 
 (a) Members of the Board who are eligible to participate
in the Plan may not vote on any matter affecting the administration of the Plan or the grant of any option pursuant to the Plan. 
 (b) If a committee is established to administer the Plan, no member of the Board who is eligible to participate in the Plan may be a member of the committee. 
  

	14.	DESIGNATION OF BENEFICIARY (FOR EMPLOYEES IN THE UNITED STATES ONLY) 

 The provisions of this Section 14 apply only to participants in the United States: 
 (a) A participant may file a written designation of a beneficiary who is to receive any shares and cash, if any, from the participant’s account under the Plan in the event of such participant’s 
  

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 death subsequent to the end of the Offering Period but prior to delivery to him of such shares and cash. In
addition, a participant may file a written designation of a beneficiary who is to receive any cash from the participant’s account under the Plan in the event of such participant’s death prior to the exercise of the option. 
 (b) Such designation of beneficiary may be changed by the participant at any time by written notice. In the event of the death of a
participant and in the absence of a beneficiary validly designated under the Plan who is living at the time of such participant’s death, the Company shall deliver such shares and/or cash to the executor or administrator of the estate of the
participant, or if no such executor or administrator has been appointed (to the knowledge of the Company), the Company, in its discretion, may deliver such shares and/or cash to the spouse or to any one or more dependents or relatives of the
participant, or if no spouse, dependent or relative is known to the Company, then to such other person as the Company may designate. 
  

	15.	TRANSFERABILITY 

 Neither payroll
deductions credited to a participant’s account nor any rights with regard to the exercise of an option or to receive shares under the Plan may be assigned, transferred, pledged or otherwise disposed of in any way (other than by will, the laws
of descent and distribution or as provided in Section 14 hereof) by the participant. Any such attempt at assignment, transfer, pledge or other disposition shall be without effect, except that the Company may treat such act as an election to
withdraw funds in accordance with Section 10. 
  

	16.	USE OF FUNDS 

 All payroll
deductions received or held by the Company under the Plan may be used by the Company for any corporate purpose, and the Company shall not be obligated to segregate such payroll deductions (unless otherwise required by local law). 
  

	17.	REPORTS 

 Individual accounts
will be maintained for each participant in the Plan. Statements of account will be given to participating Employees semi-annually promptly following each Exercise Date, which statements will set forth the amounts of payroll deductions, the per share
purchase price, the number of shares purchased and the refunds, if any. 
  

	18.	ADJUSTMENTS UPON CHANGES IN CAPITALIZATION 

 Subject to any required action by the stockholders of the Company, the number of shares of Common Stock covered by each option under the Plan which has not yet been exercised (including the increase set
forth in Section 12 hereof) and the number of shares of Common Stock which have been authorized for issuance under the Plan but have not yet been placed under option (collectively, the “Reserves”), as well as the price per share of
Common Stock covered by each option under the Plan which has not yet been exercised, shall be proportionately adjusted for any increase or decrease in the number of issued shares of Common Stock resulting from a stock split or the payment of a stock
dividend (but only on the Common Stock) or any other increase or decrease in the number of shares of 
  

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 Common Stock effected without receipt of consideration by the Company; provided, however, that conversion of
any convertible securities of the Company shall not be deemed to have been “effected without receipt of consideration.” Such adjustment shall be made by the Board, whose determination in that respect shall be final, binding and conclusive.
Except as expressly provided herein, no issue by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number or
price of shares of Common Stock subject to an option. 
 In the event of the proposed dissolution or liquidation of the Company,
the Offering Period will terminate immediately prior to the consummation of such proposed action, unless otherwise provided by the Board. In the event of a proposed sale of all or substantially all of the assets of the Company, or the merger of the
Company with or into another entity, the Board, in its sole discretion, may provide that (i) each option under the Plan shall be assumed, (ii) an equivalent option shall be substituted by such successor entity or a parent or subsidiary of
such successor entity, or in lieu of such assumption or substitution, that the participant shall have the right to exercise the option, including shares as to which the option would not otherwise be exercisable, or (iii) the Plan shall
terminate and a shortened Offering Period will take place with a purchase occurring on a date determined by the Board or a participant’s contributions returned. 
 The Board may, if it so determines in the exercise of its sole discretion, also make provision for adjusting the Reserves, as well as the price per share of Common Stock covered by each outstanding
option, if the Company effects one or more reorganizations, recapitalizations, rights offerings or other increases or decreases of the shares of its outstanding Common Stock, and if the Company is being consolidated with or merged into any other
corporation. 
  

	19.	AMENDMENT OR TERMINATION 

 The
Board may at any time terminate or amend the Plan. No such termination can affect options previously granted, nor may an amendment make any change in any option theretofore granted which adversely affects the rights of any participant, nor may an
amendment be made without prior approval of the stockholders of the Company if such amendment is required by law or otherwise to be approved by the stockholders. 
 Amendments to the Code which impact the Plan shall be automatically implemented without further action by the Board unless such amendments require independent action by either the Board or the
stockholders. 
 In the event the Board determines that the ongoing operation of the Plan may result in unfavorable financial
accounting consequences to the Company, the Board may in any manner it determines, in its sole discretion, and, to the extent necessary or desirable, modify or amend the Plan to reduce or eliminate such accounting consequence including, but not
limited to altering the purchase price for any Offering Period including an Offering Period underway at the time of the change in purchase price. Such modifications or amendments shall not require stockholder approval or the consent of any Plan
participants. 
  

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	20.	NOTICES 

 All notices or other
communications by a participant to the Company under or in connection with the Plan shall be deemed to have been duly given when received in the form specified by the Company at the location, or by the person, designated by the Company for the
receipt thereof. 
  

	21.	STOCKHOLDER APPROVAL 

 Continuance of the Plan shall be subject to approval by the stockholders of the Company within 12 months before or after the date the Plan is adopted. If such stockholder approval is obtained at a duly held stockholders meeting, it may be
obtained by the affirmative vote of the holders of a majority of the outstanding shares of the Company present or represented and entitled to vote thereon, which approval shall be: 
 (a)     (i) solicited substantially in accordance with Section 14(a) of the Securities Exchange Act of 1934,
as amended (the “Act”) and the rules and regulations promulgated thereunder, or 
 (ii) solicited after
the Company has furnished in writing to the holders entitled to vote substantially the same information concerning the Plan as that which would be required by the rules and regulations in effect under Section 14(a) of the Act at the time such
information is furnished; and 
 (b) obtained at or prior to the first annual meeting of stockholders held subsequent to the
first registration of Common Stock under Section 12 of the Act. 
 In the case of approval by written consent, it must be obtained by the
unanimous written consent of all stockholders of the Company. 
  

	22.	CONDITIONS UPON ISSUANCE OF SHARES 

 Shares shall not be issued with respect to an option unless the exercise of such option and the issuance and delivery of such shares pursuant thereto shall comply with all applicable provisions of law, domestic or foreign, including,
without limitation, the Securities Act of 1933, as amended, the Securities Exchange Act of 1934, as amended, the rules and regulations promulgated thereunder, and the requirements of any stock exchange upon which the shares may then be listed, and
shall be further subject to the approval of counsel for the Company with respect to such compliance. 
 As a condition to the
exercise of an option, the Company may require the person exercising such option to represent and warrant at the time of any such exercise that the shares are being purchased only for investment and without any present intention to sell or
distribute such shares if, in the opinion of counsel for the Company, such a representation is required by any of the aforementioned applicable provisions of law. 
  

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	23.	RULES FOR FOREIGN JURISDICTIONS 

 Notwithstanding any provision to the contrary in this Plan, the Board may adopt rules or procedures relating to the operation and administration of the Plan to accommodate the specific requirements of local laws and procedures. Without
limiting the generality of the foregoing, the Board is specifically authorized to adopt rules and procedures regarding the definition of Compensation, handling of payroll deductions, making of contributions to the Plan in forms other than payroll
deductions, establishment of bank or trust accounts to hold payroll deductions, payment of interest, conversion of local currency, obligations to pay payroll tax, withholding procedures and delivery of shares which vary with local requirements.

  

 - 10 -Fourth Amended and Restated Investor Rights Agreement

 Exhibit 4.2 
 Execution Version 
 BG MEDICINE, INC. 
 FOURTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 
 THIS FOURTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Agreement”) is made as of July 10, 2008, by
and among BG Medicine, Inc., a Delaware corporation (the “Company”), and the holders of capital stock of the Company as set forth on Schedule A hereto (the “Preferred Stockholders”). 
 R E C I T A L S: 
 A. Whereas the Preferred Stockholders own shares of Series A Preferred Stock, par value $0.001 per share, of the Company (the “Series A Preferred Stock”), Series A-1 Preferred Stock, par value $0.001 per share, of the
Company (the “Series A-1 Preferred Stock”), Series B Preferred Stock, par value $0.001 per share, of the Company (the “Series B Preferred Stock”), Series C Preferred Stock, par value $0.001 per share, of the Company
(the “Series C Preferred Stock”), and Series D Preferred Stock, par value $0.001 per share, of the Company (the “Series D Preferred Stock” and collectively with the Series A Preferred Stock, Series A-1 Preferred Stock,
Series B Preferred Stock and Series C Preferred Stock, the “Preferred Stock”) convertible into shares of Common Stock, par value $0.001 per share, of the Company (the “Common Stock”). 
 B. Whereas the Company, certain of the Preferred Stockholders and certain other parties entered into an Investor Rights Agreement dated as
of April 20, 2001 and subsequently amended and restated such agreement on October 28, 2004, March 28, 2005 and May 1, 2007 and then subsequently amended such amended and restated agreement on December 27,
2007, March 28, 2008 and June 23, 2008 (the “Investor Rights Agreement”) 
 D. Whereas the
Company and the Preferred Stockholders holding at least 50% of the Registrable Securities (as defined in the Investor Rights Agreement) desire to amend and restate in its entirety the Investor Rights Agreement by their execution of this Agreement.

 Now, therefore, the parties hereto agree as follows: 
 A G R E E M E N T: 
 1. Certain Definitions. As used
in this Agreement, the following terms shall have the following respective meanings: 
 “Board” shall mean the
Company’s Board of Directors. 
 “Commission” shall mean the U.S. Securities and Exchange Commission.

 “Exchange Act” shall mean the U.S. Securities Exchange Act of 1934, as amended, and the rules and
regulations of the Commission promulgated thereunder, all as the same shall be in effect from time to time. 
  

 1 

 “Holders” or “Holders of Registrable Securities” shall
mean the Preferred Stockholders and any Person who shall have acquired Registrable Securities from the Preferred Stockholders as permitted herein, either individually or jointly, as the case may be, in a transaction pursuant to which registration
rights are transferred pursuant to Section 10 hereof. 
 “IPO” shall mean an initial public offering in
which all outstanding shares of Preferred Stock are converted pursuant to the automatic conversion provisions contained in the Company’s certificate of incorporation, as amended from time to time. 
 “Person” shall mean an individual, a partnership, a corporation, a limited liability company, an association, a joint stock
company, a trust, a joint venture, an unincorporated organization or a governmental or quasi-governmental entity, or any department, agency or political subdivision thereof or any other entity of any kind. 
 “Registrable Securities” shall mean (i) any shares of Common Stock at any time beneficially owned by the Preferred
Stockholders or their respective affiliates (including shares of Common Stock issued or issuable upon conversion or exercise of the Preferred Stock), as the case may be; and (ii) any shares of Common Stock issued or issuable in respect of the
securities referred to in clause (i) above, whether to satisfy interest or dividend payments or upon any stock split, stock dividend, recapitalization or otherwise, until, in the case of any such security, it is (A) sold pursuant to an
effective registration statement under the Securities Act; (B) eligible to be sold into the public market by persons who are not “affiliates” (as defined in Rule 144 promulgated under the Securities Act) of the Company (and have not
been affiliates of the Company for the preceding three months) pursuant to the second sentence of Rule 144(b)(1)(i) (or any successor rule); (C) sold pursuant to Rule 144 under the Securities Act (or any successor rule); or (D) sold by a
Person in a transaction in which registration rights are not transferred pursuant to Section 8 hereof. Whenever reference is made in this Agreement to a request or consent of holders of a certain number or percentage of Registrable Securities,
the determination of such number or percentage shall be calculated on the basis of shares of Common Stock issued or issuable pursuant to the conversion of shares of Preferred Stock. 
 The terms “register,” “registered” and “registration” refer to a registration effected by
preparing, filing and having declared effective a registration statement in compliance with the Securities Act. 
 “Registration Expenses” shall mean (i) all expenses, other than Selling Expenses (defined below), incurred by the Company in complying with Sections 2 or 3 hereof, including without limitation, all registration,
qualification and filing fees, exchange or quotation medium listing fees, printing and delivery expenses, escrow and custodian fees, fees and disbursements of counsel for the Company, blue sky fees and expenses and the expenses of accountants for
the Company including the expenses of any special audits incident to or required by any such registration and (ii) the reasonable fees and disbursements of one counsel chosen by the holders of a majority of the Registrable Securities included
in such registration for the purpose of rendering a legal opinion on behalf of such holders in connection with any Demand Registration or Piggyback Registration. 
 “Securities Act” shall mean the U.S. Securities Act of 1933, as amended, and the rules and regulations of the Commission promulgated thereunder, all as the same shall be in effect from
time to time. 
  

 2 

 “Selling Expenses” shall mean all underwriting discounts, selling
commissions and stock transfer taxes and the costs, fees and expenses of any accountants, attorneys (other than the cost, fees and expenses of attorneys which are Registration Expenses) or other experts retained by the Holders. 
 2. Holders Demand Registrations. 
 (a) Request for Registration. At any time following the first six months after the date of effectiveness of a registration statement filed under the Securities Act in respect of an initial public
offering of shares of Common Stock of the Company, any Holder or Holders who collectively hold Registrable Securities representing at least 40% of the Registrable Securities then outstanding shall have the right (subject to the limitations set forth
below), exercisable by written notice to the Company (each a “Registration Request”), to have the Company prepare and file with the Commission a registration statement under the Securities Act covering the Registrable Securities
that are the subject of such request (each, a “Demand Registration”); provided, that the Company shall not be obligated to prepare and file a registration statement if neither Form S-3 nor another short form registration
statement is available to the Company to fulfill such Registration Request, unless the Registrable Securities that are the subject of such request have an expected aggregate offering price to the public of at least U.S.$1,000,000. Within 10 days
after receipt of any such request, the Company will give written notice of such requested registration to all other Holders of Registrable Securities. The Company shall include such other Holders’ Registrable Securities in such offering if they
have responded affirmatively within 10 days after the receipt of the Company’s notice. Subject to the foregoing, the Holders shall be permitted one Demand Registration hereunder. 
 A request for registration under this Section 2(a) will not count as a Demand Registration until the registration statement has become
effective and remained effective until the earlier of 30 days and the sale of all securities registered thereunder (unless such registration statement has not become effective due solely to the actions or failure to act with respect to such
registration of the Holders requesting such registration, including a request by such Holders that such registration be withdrawn). 
 (b) Priority on Holders Demand Registrations. If a Demand Registration is an underwritten offering and the managing underwriters advise the Company in writing that in their opinion the number of
Registrable Securities and, if permitted hereunder, other securities requested to be included in such offering, exceeds the number of Registrable Securities and other securities, if any, which can be sold in such offering without adversely affecting
the marketability of the offering, the Company will include in such registration: 
 i. first, the Registrable
Securities requested to be included in such registration by the Holders (or, if necessary, such Registrable Securities pro rata among the Holders thereof based upon the number of Registrable Securities owned by each such Holder or such
other arrangement agreed to among the Holders); and 
 ii. thereafter, other securities requested to be included
in such registration, as determined by the Company. 
 If, solely as a result of the pro rata cutback limitation set forth in
this Section 2(b), the number of Registrable Securities requested by Holders to be included in the Demand Registration exceeds the number of Registrable Securities actually included in the Demand Registration, the Holders shall be entitled to a
second Demand Registration for the sole purpose of including the Registrable Securities that had been excluded from the first Demand Registration; provided, however, such second Registration

  

 3 

 
Request may not be made until six months following the date of effectiveness of the registration statement filed for the first Demand Registration. If a second Demand Registration is effected for
this purpose, it shall be considered a “Demand Registration” for all purposes of this Agreement, including, without limitation, the threshold, notice, priority and other requirements. 
 The Holders of any Registrable Securities to be included in such an underwritten offering shall enter into an underwriting agreement (which
shall be in customary form, may include agreements as to indemnification and contribution and shall provide that the representations and warranties by the Company to and for the benefit of such underwriters, shall also be made to and for the benefit
of such Holders). 
 (c) Restrictions on Demand Registration. The Company may postpone or suspend, for up
to 90 days in any 12-month period, the filing or the effectiveness of a registration statement for a Demand Registration if the Board determines in good faith and notifies the Holders in writing that such Demand Registration (i) would
reasonably be expected to have a material adverse effect on (x) any proposal or plan by the Company to engage in any financing, acquisition or disposition of assets (other than in the ordinary course of business) or (y) any merger,
consolidation, tender offer or similar transaction or (ii) would require disclosure of any information that the Board determines in good faith the disclosure of which would be detrimental to the Company; provided, however, that in
such event, the Holders initially requesting such Demand Registration shall be entitled to withdraw such request and, if such request is withdrawn, such Demand Registration will not count as a permitted Demand Registration hereunder and the Company
will pay any Registration Expenses in connection with such registration. 
 (d) Selection of Investment
Bankers and Managers. The Company will have the right to select the investment banker(s) and manager(s) to administer an offering pursuant to the Demand Registration, subject to the approval of the holders of a majority of the Registrable
Securities, which will not be unreasonably withheld, delayed or conditioned. 
 (e) The Company represents and
warrants that it is not a party to, or otherwise subject to, any agreement, other than this Agreement, granting registration rights to any other Person with respect to any securities of the Company. 
 3. Piggyback Registrations. 
 (a) Right to Piggyback. If at any time after the Company has closed an IPO, the Company shall propose to register shares of Common Stock under the Securities Act (other than in a registration
statement relating solely to sales of securities to participants in a Company dividend reinvestment plan, or Form S-4 or S-8 or any successor form or in connection with an acquisition or exchange offer or an offering of securities solely to the
existing shareholders or employees of the Company), the Company (i) will give prompt written notice to all Holders of Registrable Securities of its intention to effect such a registration and (ii) subject to Section 2(b) and
Section 3(b) and the other terms of this Agreement, will include in such registration all Registrable Securities which are permitted under applicable securities laws to be included in the form of registration statement selected by the Company
and with respect to which the Company has received written requests for inclusion therein within 30 days after the receipt of the Company’s notice (each, a “Piggyback Registration”); provided, however, that the
Company shall not be obligated to include Registrable Securities of a Holder who is not an “affiliate” (as defined in Rule 144) of the Company (and has not been an affiliate of the Company

  

 4 

 
for the preceding three months) which are eligible for resale into the public market pursuant to the second sentence of Rule 144(b)(1)(i) (or any successor rule). The Holders will be permitted to
withdraw all or any part of the Registrable Securities from a Piggyback Registration at any time prior to the effective date of such Piggyback Registration. 
 (b) Priority on Piggyback Registrations. If a Piggyback Registration is to be an underwritten offering, and the
managing investment bank advises the Company in writing that in their opinion the number of securities requested to be included in such registration exceeds the number which can be sold in such offering without adversely affecting the marketability
of the offering, the Company will include in such registration: 
 i. first, the securities the Company proposes
to sell for its own account; 
 ii. second, the Registrable Securities requested to be included in such
registration by the Holders and any securities requested to be included in such registration by any other Person pursuant to a demand registration request, other than Persons having a lower priority of registration than the Holders, pro
rata among the Holders of such Registrable Securities and such other Persons, on the basis of the number of securities requested to be included in such registration by each of such Holders and such other Persons; and 
 iii. thereafter, other securities requested to be included in such registration, as determined by the Company. 
 The Holders of any Registrable Securities to be included in an underwritten offering shall enter into an underwriting agreement (which shall
be in customary form, may include agreements as to indemnification and contribution, and shall provide that the representations and warranties by the Company to and for the benefit of such underwriters, shall also be made to and for the benefit of
such Holders). Notwithstanding (i) – (iii) above, the number of securities held by each Holder of Series B Preferred Stock to be included in such registration shall not be reduced to less than 20% of the total number of securities to
be included in such registration. 
 (c) Right to Terminate Registration. If at any time after giving
written notice of its intention to register any of its securities as set forth in Section 3(a) and prior to the effective date of the registration statement filed in connection with such registration, the Company shall determine for any reason
not to register such securities, the Company may, at its election, give written notice of such determination to each Holder of Registrable Securities and thereupon be relieved of its obligation to register any Registrable Securities in connection
with such registration (but not from its obligation to pay the Registration Expenses in connection therewith as provided herein). 
 (d) Selection of Underwriters/Placement Agents. The Company will have the right to select the investment banker(s) and manager(s) to administer an offering pursuant to a Piggyback Registration,
subject to the approval of the holders of a majority of the Registrable Securities, which approval will not be unreasonably withheld, delayed or conditioned. 
 4. Expenses of Registration. Except as otherwise provided herein or as may otherwise be prohibited by applicable law, all Registration Expenses incurred in connection with all registrations
pursuant to Sections 2 and 3 hereof shall be borne by the Company. All Selling Expenses relating to securities registered on behalf of the Holders of Registrable Securities shall be borne by such Holders. 
  

 5 

 5. Holdback Agreements. 
 (a) The Company agrees (i) if requested by the underwriters managing the offering, not to effect any public sale or
distribution of its equity securities, or any securities convertible into or exchangeable or exercisable for such securities, during the 10-day period prior to, and during the 90-day period following, the effective date of any underwritten Demand
Registration or any underwritten Piggyback Registration (except as part of such underwritten registration or pursuant to registration statements on Form S-4 or Form S-8 or any successor form), and (ii) to use its best efforts to cause its
officers and directors and each holder of at least 5% (on a fully-diluted basis) of its outstanding shares of Common Stock, or any securities convertible into or exchangeable or exercisable for shares of Common Stock, purchased from the Company at
any time after the date of this Agreement (other than in a registered public offering) to agree not to effect any public sale or distribution (including sales pursuant to Rule 144) of any such securities during such periods (except as part of such
underwritten registration, if otherwise permitted), unless the underwriters managing the registered public offering otherwise agree. 
 (b) If requested by the managing underwriter(s) in an underwritten offering of Common Stock or securities convertible for Common Stock of the Company (including without limitation the Company’s
initial public offering of Common Stock), each Holder agrees, unless such Holder is a participant in such offering, not to effect any offer, sale, distribution or transfer, including a sale pursuant to Rule 144 (or any similar provision then effect)
under the Securities Act (except as part of such underwritten registration), during the 10-day period prior to, and during (A) the 180-day period in the case of the Company’s initial public offering, if applicable, or (B) the 90-day
period in the case of any other public offering of Common Stock (or, in each case of (A) and (B), (X) such longer period, if required by such underwriter, as is necessary to enable such underwriter to issue a report or make a public
appearance that relates to an earnings release or announcement by the Company during an additional 15-day period, or (Y) such shorter period, as may be agreed to in writing by the Company and the Holders of at least 50% of the Registrable
Securities) following, the effective date of such Registration Statement; provided, however, that (i) no Holder shall be required to enter into more than two such agreements in any 12-month period and (ii) no Holder
shall be required to enter into such an agreement unless all Persons entitled to registration rights who are not parties to this Agreement, all other Persons selling shares in such offering, all Persons holding in excess of 5% (on a fully diluted
basis) of the Company’s outstanding shares of Common Stock (other than that purchased in a registered public offering) and all executive officers and directors of the Company shall also have agreed not to offer, sell, distribute a transfer
under the circumstances and pursuant to the terms set forth in this Section 5(b). 
 6. Registration Procedures.
Whenever the Holders of Registrable Securities have requested that any Registrable Securities be registered pursuant to this Agreement, the Company will use its best efforts to effect the registration and the sale of such Registrable Securities in
accordance with the intended method or methods of distribution thereof, and pursuant thereto the Company will under the time frames provided herein, or if not so provided, as expeditiously as possible: 
 (a) prepare and file with the Commission a registration statement on any appropriate form for which the Company qualifies
with respect to such Registrable Securities and use its best efforts to cause such registration statement to become effective (provided that before filing a registration statement or prospectus or any amendments or supplements thereto, the
Company will (i) furnish to the counsel selected by the Holders copies of all such documents proposed to be filed, which documents will be subject to the review of such counsel, and (ii) notify each Holder of Registrable Securities covered
by such registration of any stop order issued or threatened by the Commission); 
  

 6 

 (b) prepare and file with the Commission such amendments and supplements to
such registration statement and the prospectus used in connection therewith as may be reasonably necessary to keep such registration statement effective for a period equal to the shorter of (i) 180 days and (ii) the time by which all
securities covered by such registration statement have been sold, and comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement during such period in accordance with the
intended methods of disposition by the sellers thereof set forth in such registration statement; 
 (c) furnish
to each seller of Registrable Securities such number of copies of such registration statement, each amendment and supplement thereto, the prospectus included in such registration statement (including each preliminary prospectus) and such other
documents as such seller may reasonably request in order to facilitate the disposition of the Registrable Securities owned by such seller; 
 (d) use all reasonable efforts to register or qualify such Registrable Securities under the securities or blue sky laws of such jurisdictions as any seller reasonably requests and do any and all other
acts and things which may be reasonably necessary or advisable to enable such seller to consummate the disposition in such jurisdictions of the Registrable Securities owned by such seller (provided that the Company will not be required to
(i) qualify generally to do business in any jurisdiction where it would not otherwise be required to qualify but for this Section 6(d), (ii) subject itself to taxation in any jurisdiction or (iii) take any action that would
subject it to general service of process in any such jurisdiction); 
 (e) promptly notify each seller of such
Registrable Securities, at any time when a prospectus relating thereto is required to be delivered under the Securities Act, of the happening of any event as a result of which the prospectus included in such registration statement contains an untrue
statement of a material fact or omits any material fact necessary to make the statements therein not misleading, and, the Company will prepare and deliver to each Holder a supplement or amendment to such prospectus so that, as thereafter delivered
to the purchasers of such Registrable Securities, such prospectus will not contain an untrue statement of a material fact or omit to state any material fact necessary to make the statements therein not misleading; provided, however,
that the Company shall be required to notify the Holders, but shall not be required to amend the registration statement or supplement the prospectus for a period of up to three months if the Board determines in good faith that to do so would
reasonably be expected to have a material adverse effect on any proposal or plan by the Company to engage in any financing, acquisition or disposition of assets (other than in the ordinary course of business) or any merger, consolidation, tender
offer or similar transaction or would require the disclosure of any information that the Board determines in good faith the disclosure of which would be materially detrimental to the Company, it being understood that the period for which the Company
is obligated to keep the Registration Statement effective shall be extended for a number of days equal to the number of days the Company delays amendments or supplements pursuant to this provision. Upon receipt of any notice pursuant to this
Section 6(e), the Holders shall suspend all offers and sales of securities of the Company and all use of any prospectus until advised by the Company that offers and sales may resume, and shall keep confidential the fact and content of any
notice given by the Company pursuant to this Section 6(e); 
  

 7 

 (f) cause all such Registrable Securities to be listed on each securities
exchange or quoted on Nasdaq or other quotation medium, if any, on which similar securities issued by the Company are then listed or quoted; 
 (g) provide a transfer agent and registrar for all such Registrable Securities not later than the effective date of such registration statement; 
 (h) enter into such customary agreements (including underwriting agreements in customary form) and take all such other
actions as the Holders of a majority of the Registrable Securities being sold or the underwriters, if any, reasonably request in order to expedite or facilitate the disposition of such Registrable Securities (including effecting a stock split or a
combination of shares); 
 (i) make available for inspection by the Holders of Registrable Securities included in
the registration statement, any underwriter participating in any disposition pursuant to such registration statement and any attorney, accountant or other agent retained by any such seller or underwriter, all pertinent financial and other records,
pertinent corporate documents and properties of the Company, and cause the Company’s officers, directors, employees and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant
or agent in connection with such registration statement and (ii) to participate in presentations to prospective purchasers as reasonably requested by any underwriter or placement agent; 
 (j) otherwise use its best efforts to comply with all applicable rules and regulations of the Commission, and make available
to its security holders, as soon as reasonably practicable, an earnings statement covering the period of at least 12 months beginning with the first day of the Company’s first full calendar quarter after the effective date of the registration
statement, which earnings statement shall satisfy the provisions of Section 10(a) of the Securities Act and Rule 158 thereunder; 
 (k) in the event of the issuance of any stop order suspending the effectiveness of a registration statement, or of any order suspending or preventing the use of any related prospectus or suspending the
qualification of any shares of Common Stock included in such registration statement for sale in any jurisdiction, use its best efforts promptly to obtain the withdrawal of such order; 
 (l) obtain a so-called “cold comfort” letter from the Company’s independent public accountants in customary
form and covering such matters of the type customarily covered by cold comfort letters; 
 (m) use its best
efforts to cause such Registrable Securities covered by such registration statement to be registered with or approved by such other governmental agencies or authorities as may be necessary to enable the sellers thereof to consummate the disposition
of such Registrable Securities; and 
 (n) if any such registration or comparable statement refers to any Holder
by name or otherwise as the holder of any securities of the Company and if in its sole and exclusive judgment, such Holder is or might be deemed to be an underwriter or a controlling person of the Company, such Holder shall have the right to require
(i) the insertion therein of language, in form and substance satisfactory to such Holder and presented to the Company in writing, to the effect that the holding by such Holder of such securities is not to be construed as a recommendation by
such Holder of the investment quality of the Company’s securities covered thereby and that such holding does not imply that such Holder shall assist in meeting any future financial requirements of the Company, or (ii) in the event

  

 8 

 
that such reference to such Holder by name or otherwise is not required by the Securities Act or any similar Federal statute then in force, the deletion of the reference to such Holder;
provided that with respect to this clause (ii) such Holder shall (a) furnish to the Company an opinion of counsel to such effect, which opinion and counsel shall be reasonably satisfactory to the Company and (b) indemnify the
Company against any loss or liability imposed upon and any reasonable expenses incurred by the Company as a result of such deletion. 
 7. Obligations of Holders. Whenever any Registrable Securities are registered pursuant to a Demand Registration, or a Piggyback Registration, the Holders shall be obligated to comply with the applicable provisions of the Securities
Act, including the prospectus delivery requirements thereunder, and any applicable state securities or blue sky laws. In addition, each Holder of Registrable Securities will be deemed to have agreed by virtue of its acquisition of such Registrable
Securities that, upon receipt of any notice described in Section 6(e), such Holder will forthwith discontinue disposition of such Registrable Securities covered by such registration statement or prospectus until such Holder’s receipt of
the copies of the supplemented or amended prospectus contemplated by Section 6(e), or until it is advised in writing by the Company that the use of the applicable prospectus may be resumed, and has received copies of any additional or
supplemental filings that are incorporated or deemed to be incorporated by reference in such prospectus. 
 8.
Indemnification. 
 (a) The Company agrees to indemnify, to the fullest extent permitted by applicable
law, each Holder of Registrable Securities, its officers and directors and each Person who controls such Holder (within the meaning of the Securities Act) against all losses, claims, damages, liabilities, expenses or any amounts paid in settlement
of any litigation, investigation or proceeding commenced or threatened (collectively, “Claims”) to which each such indemnified party may become subject under the Securities Act insofar as such Claim arose out of (i) any untrue
or alleged untrue statement of material fact contained in any registration statement, prospectus or preliminary prospectus or any amendment thereof or supplement thereto, or (ii) any omission or alleged omission to state therein a material fact
required to be stated therein or necessary to make the statements therein not misleading, except insofar as the same are caused by or contained in any information furnished in writing to the Company by such Holder expressly for use therein or by
such Holder’s failure to deliver a copy of the registration statement or prospectus or any amendments or supplements thereto after the Company has furnished such Holder with a sufficient number of copies of the same. In connection with an
underwritten offering, the Company will indemnify the underwriters, their officers and directors and each Person who controls the underwriters (within the meaning of the Securities Act) to the same extent as provided above with respect to the
indemnification of the Holders of Registrable Securities. 
 (b) In connection with any registration statements
in which a Holder of Registrable Securities is participating, each such Holder will, to the fullest extent permitted by applicable law, indemnify the Company, its directors and officers and each Person who controls the Company (within the meaning of
the Securities Act) against any and all Claims to which each such indemnified party may become subject under the Securities Act insofar as such Claim arose out of (i) any untrue or alleged untrue statement of material fact contained in any
registration statement, prospectus or preliminary prospectus or any amendment thereof or supplement thereto, (ii) any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the
statements therein not misleading; provided that with respect to a Claim arising pursuant to clause (i) or (ii) above, the material misstatement or omission is contained in the information such Holder provided to the Company

  

 9 

 
pursuant to Section 11 hereof; provided, further, that the obligation to indemnify will be individual to each Holder and will be limited to the amount of proceeds received by
such Holder from the sale of Registrable Securities pursuant to such registration statement. 
 (c) Any Person
entitled to indemnification hereunder will (i) give prompt written notice to the indemnifying party of any claim with respect to which it seeks indemnification (but the failure to provide such notice shall not release the indemnifying party of
its obligation under paragraphs (a) and (b), unless and then only to the extent that, the indemnifying party has been prejudiced by such failure to provide such notice) and (ii) unless in such indemnified party’s reasonable judgment,
based on written advice of counsel, a conflict of interest between such indemnified and indemnifying parties may exist with respect to such claim, permit such indemnifying party to assume the defense of such claim with counsel reasonably
satisfactory to the indemnified party. An indemnifying party who is not entitled to, or elects not to, assume the defense of a claim will not be obligated to pay the fees and expenses of more than one counsel for all parties indemnified by such
indemnifying party with respect to such claim, unless in the reasonable judgment of any indemnified party, based on written advice of counsel, a conflict of interest may exist between such indemnified party and any other of such indemnified parties
with respect to such claim. 
 (d) The indemnifying party shall not be liable to indemnify an indemnified party
for any settlement, or consent to judgment of any such action effected without the indemnifying party’s written consent (but such consent will not be unreasonably withheld, delayed or conditioned). Furthermore, the indemnifying party shall not,
except with the prior written approval of each indemnified party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to each indemnified party
of a release from all liability in respect of such claim or litigation without any payment or consideration provided by each such indemnified party. 
 (e) If the indemnification provided for in this Section 8 is unavailable to an indemnified party under clauses (a) and (b) above in respect of any losses, claims, damages or liabilities
referred to therein, then each indemnifying party, in lieu of indemnifying such indemnified party, shall contribute to the amount paid or payable by such indemnified party as a result of such losses, claims, damages or liabilities in such proportion
as is appropriate to reflect not only the relative benefits received by the Company, the underwriters, the sellers of Registrable Securities and any other sellers participating in the registration statement from the sale of shares pursuant to the
registered offering of securities for which indemnity is sought but also the relative fault of the Company, the underwriters, the sellers of Registrable Securities and any other sellers participating in the registration statement in connection with
the misstatement or omission which resulted in such losses, claims, damages or liabilities, as well as any other relevant equitable considerations. The relative benefits received by the Company, the underwriters, the sellers of Registrable
Securities and any other sellers participating in the registration statement shall be deemed to be based on the relative relationship of the total net proceeds from the offering (before deducting expenses) to the Company, the total underwriting
commissions and fees from the offering (before deducting expenses) to the underwriters and the total net proceeds from the offering (before deducting expenses) to the sellers of Registrable Securities and any other sellers participating in the
registration statement. The relative fault of the Company, the underwriters, the sellers of Registrable Securities and any other sellers participating in the registration statement shall be determined by reference to, among other things, whether the
untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company or by the sellers of Registrable Securities and the parties’ knowledge, access to
information

  

 10 

 
and opportunity to correct or prevent such statement or omission; provided that in no event shall the liability of any selling Holder hereunder be greater in amount than the dollar amount
of the proceeds received by such Holder upon the sale of the Registrable Securities giving rise to such indemnification obligation. 
 (f) The indemnification provided for under this Agreement will remain in full force and effect regardless of any investigation made by or on behalf of the indemnified party or any officer, director or
controlling person of such indemnified party and will survive the transfer of the Registrable Securities. 
 9. Participation
in Underwritten Registrations. No Person may participate in any registration hereunder which is underwritten unless such Person (a) agrees to sell such Person’s securities on the basis provided in any underwriting arrangements approved
by the Person or Persons entitled hereunder to approve such arrangements and (b) completes and executes all questionnaires, powers of attorney, indemnities, underwriting agreements and other documents reasonably required under the terms of such
underwriting arrangements; provided that no Holder of Registrable Securities included in any underwritten registration shall be required to make any representations or warranties to the Company or the underwriters (other than representations
and warranties regarding such Holder and such Holder’s intended method of distribution) or to undertake any indemnification obligations to the Company or the underwriters with respect thereto, except as otherwise provided in paragraph 9 hereof.

 10. Transfer of Registration Rights. The rights granted to any Holder under this Agreement may be assigned to any
Person in connection with any transfer or assignment by a Holder of at least 20% of the Registrable Securities held by such Holder pursuant to the conversion or exercise of Preferred Stock or to any transferee who is a partner or shareholder of such
Holder, or to any entity which, directly or indirectly, controls, is controlled by or is under common management with such Holder; provided, however, that: (a) such transfer is otherwise effected in accordance with applicable
securities laws, (b) such transfer is not in violation of any effective agreement between the Company and any of the Preferred Stockholders and (c) if not already a party hereto, the assignee or transferee agrees in writing prior to such
transfer to be bound by the provisions of this Agreement. 
 11. Information by Holder. Each Holder shall furnish to the
Company such written information regarding such Holder and any distribution proposed by such Holder as the Company may reasonably request in writing and as shall be reasonably required in connection with any registration, qualification or compliance
referred to in this Agreement and shall promptly notify the Company of any changes in such information. 
 12. Right of First
Refusal on Certain Issuances. 
 (a) The Preferred Stockholders shall have the right (but not the obligation)
to participate in any equity financing, any financing involving securities convertible or exchangeable for equity, or any grant of options, warrants or other rights to purchase any capital stock of the Company or any security convertible or
exchangeable for any capital stock of the Company (the “Rights”), in each case, consummated, or proposed to be consummated, by the Company, on the same or monetarily equivalent terms and conditions offered to the other proposed
investors in such financing or recipient of such grant, in order for the Preferred Stockholders and their affiliates to maintain their pro rata, fully-diluted interest in the Company represented solely by their ownership of Preferred Stock (the
“Right of First Refusal”). If, in connection with such issuance, securities are to be issued and sold for consideration other than cash, then the Board shall, in good faith, determine the fair market value of

  

 11 

 
such non-cash consideration, subject to the Preferred Stockholders’ reasonable approval (provided, that if the Preferred Stockholders shall not approve such valuation, the Company and the
Preferred Stockholders shall agree upon a third party appraiser who shall determine the cash valuation of such non-cash consideration), and offer to sell the subject securities as set forth herein for the cash equivalent of such non-cash
consideration. The Company shall provide a notice of such a proposed offering (“New Issue Notice”) to the Preferred Stockholders at least 20 days prior to the closing of the proposed offering and shall state the Company’s bona
fide intent to offer such securities or Rights, the number of securities or Rights to be offered (a calculation of the number of shares of Common Stock into which such securities may be converted or exchanged or such Rights may be exercised), the
identity of the parties to whom such securities or Rights are being offered, and the price and terms, if any, upon which it proposes to offer such securities. The Right of First Refusal may be exercised by the Preferred Stockholders, in whole or in
part, at any time within the 20-day period after the receipt of the New Issue Notice by delivery to the Company of a writing notifying the Company of such exercise. If the proposed offering of securities is altered in any material respect, the
Company shall send the Preferred Stockholders a revised New Issue Notice and the Preferred Stockholders shall respond thereto, each within a 20-day period commencing upon receipt of such revised notice. If any Preferred Stockholders elect not to
exercise the Right of First Refusal, the Company may sell such securities and/or grant such Rights to the parties set forth in the New Issue Notice, at any time within 60 days of the expiration of the applicable 20-day period, on terms no more
favorable to the offerees than as set forth in the New Issue Notice; provided, that if such offering is not completed within such 60-day period, such offering shall again be subject to such Right of First Refusal and the Company shall comply
with the terms of this Section 12(a). The Right of First Refusal shall not apply to any (i) equity securities issued pursuant to a plan to benefit employees, directors or consultants that is approved by the Board, (ii) equity
securities issued pursuant to an acquisition approved by the Board and determined by the Board not to be for the primary purpose of raising additional capital, (iii) equity securities issued primarily in connection with a debt or lease
financing approved by the Board, (iv) equity securities issued in connection with a relationship approved by the Board and determined in their good faith judgment to be a joint venture, licensing, development, technology, marketing or similar
strategic relationship and, in each case, shall not be for the primary purpose of raising additional capital, (v) equity securities issued to consultants, vendors and other service providers pursuant to contracts approved by the Board,
(vi) equity securities issued upon the conversion of any shares of any series of the Company’s preferred stock, (vii) securities issued or issuable pursuant to the Securities Purchase Agreement, dated as of December 27, 2007, as
amended, among the Company and the Purchasers (as defined therein) and securities issued or issuable upon conversion or exercise thereof, and (viii) securities issued or issuable pursuant to the Securities Purchase Agreement, dated as of
March 28, 2008, as amended, among the Company and the Purchasers (as defined therein) and securities issued or issuable upon conversion or exercise thereof (collectively, the “Exempt Securities”). 
 (b) The Right of First Refusal shall not apply to shares of capital stock sold in an IPO and shall terminate immediately
prior to the closing of an IPO. 
 13. Exchange Act Compliance. The Company shall comply with all of the reporting
requirements of the Exchange Act then applicable to it, if any, and shall comply with all other public information reporting requirements of the Commission which are conditions to the availability of Rule 144 for the sale of the Registrable
Securities. The Company shall cooperate with each Holder in supplying such information as may be necessary for such Holder to complete and file any information reporting forms presently or hereafter required by the Commission as a condition to the
availability of Rule 144. 
  

 12 

 14. Reporting Requirements. With respect to each Holder, for so long as such Holder
shall hold securities of the Company: 
 (a) The Company shall provide to such Holder as soon as practicable
after the end of each fiscal quarter, and in any event within 45 days after each quarter, copies of: (i) an unaudited consolidated balance sheet of the Company as at the end of such quarter, and (ii) unaudited consolidated statements of
operations and cash flows (and if prepared by the Company, a statement of stockholders’ equity) of the Company for the period ending with such quarter, setting forth in comparative form the figures for the corresponding periods in the preceding
fiscal year, in each case, certified by the chief financial officer of the Company as complete and correct, and having been prepared in accordance with generally accepted accounting principles (“GAAP”), subject to the absence of
footnotes and changes resulting from year-end adjustments. 
 (b) The Company shall provide to such Holder as
soon as practicable after the end of each fiscal year of the Company, and in any event within 120 days thereafter, copies of: (i) an audited consolidated balance sheet of the Company as at the end of such year and (ii) audited consolidated
statements of operations, stockholders’ equity and cash flows of the Company for such year, setting forth in comparative form the corresponding figures for the preceding fiscal year, together with supporting notes thereto prepared in accordance
with GAAP and accompanied by an opinion thereon of independent accountants of recognized national standing. 
 (c) The rights of the Holders to receive information and materials pursuant to this Section 14 shall terminate immediately prior to the closing of an IPO. 
 15. Miscellaneous. 
 (a) No Inconsistent Agreements.
So long as any Holder owns any Registrable Securities, the Company will not enter into any agreement that is inconsistent with or violates the rights granted hereunder to the Holders of Registrable Securities, including, without limitation, any
agreement that would require the Company to register any of its securities with priority with respect to registration over, the rights granted to the Holders hereunder, without the prior written consent of the Holders of at least 50% of the
Registrable Securities. This Agreement amends and supersedes in its entirety the Investor Rights Agreement. 
 (b) Remedies. Any Person having rights under any provision of this Agreement will be entitled to enforce such rights specifically to recover damages caused by reason of any breach of any provision of this Agreement and to exercise
all other rights granted by law. The parties hereto agree and acknowledge that money damages may not be an adequate remedy for any breach of the provisions of this Agreement and that any party may in its sole discretion apply to any court of law or
equity of competent jurisdiction (without posting any bond or other security) for specific performance and for other injunctive relief in order to enforce or prevent violation of the provisions of this Agreement; provided, however,
that in no event shall any Holder have the right to enjoin, delay or interfere with any offering of securities by the Company, if such enjoinment, delay, or interference is not required to reasonably prevent the violation of any breach of any
provision of this Agreement or any law or regulation by the Company with respect to any such offering, after reasonable notice and the opportunity to cure are provided to the Company. 
  

 13 

 (c) Amendments and Waivers. Except as otherwise provided herein, the
provisions of this Agreement may be amended or waived only with the prior written consent of the Company and Holders of at least 50% of the Registrable Securities; provided, however, that without the prior written consent of all the
Holders, no such amendment or waiver shall reduce the foregoing percentage required to amend or waive any provision of this Agreement. Notwithstanding the foregoing, additional parties shall also become parties to this Agreement and
“Holders” hereunder by executing an instrument of adherence to this Agreement with the Company. 
 (d)
Successors and Assigns. This Agreement and all of the provisions hereof shall be binding upon and inure to the benefit of the parties and their respective successors and permitted assigns. In addition, whether or not any express assignment
has been made, the provisions of this Agreement which are for the benefit of Holders of Registrable Securities are also for the benefit of, and enforceable by, any permitted transferee of Registrable Securities, in accordance with Section 10
hereof. 
 (e) Severability. In case any provision of this Agreement shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining provisions shall not be in any way affected or impaired thereby. 
 (f) Counterparts and Facsimile. This Agreement may be executed in any number of counterparts, and each such counterpart hereof shall be deemed to be an original instrument, but all such
counterparts together shall constitute one agreement. This Agreement may be signed and delivered to the other party by facsimile transmission; such transmission shall be deemed a valid signature. 
 (g) Descriptive Headings. The section and paragraph headings contained in this Agreement are for reference purposes
only and shall not affect in any way the meaning or interpretation of this Agreement. 
 (h) Governing Law;
Disputes. This Agreement shall be governed by and construed in accordance with the General Corporation Law of the State of Delaware as to matters within the scope thereof, and as to all other matters, in accordance with the internal laws of the
Commonwealth of Massachusetts (without reference to the conflicts of law provisions thereof). 
 (i)
Notices. All notices, demands and requests of any kind to be delivered to any party in connection with this Agreement shall be in writing and shall be deemed to have been duly given if personally or hand delivered or if sent by
internationally-recognized overnight courier or by registered or certified mail, return receipt requested and postage prepaid, or by facsimile transmission, addressed as follows: 
 If to the Company, to: 
 BG Medicine, Inc. 
 610 Lincoln Street North 
 Waltham, MA 02451 
 Attention: President 
 Facsimile: 781-895-1119 
 with a copy to: 
 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. 
 One Financial Center 
  

 14 

 Boston, MA 02111 
 Attention: William T. Whelan, Esq. 
 Facsimile: (617) 542-2241 
 if to a Holder, then to such Holder’s address
listed on Schedule A. 
 or to such other address as the party to whom notice is to be given may have furnished to the other party hereto
in writing in accordance with provisions of this Section 15(i). Any such notice or communication shall be deemed to have been effectively given (i) in the case of personal or hand delivery, on the date of such delivery, (ii) in the
case of an internationally-recognized overnight delivery courier, on the second business day after the date when sent or earlier upon receipt of evidence of acceptance of delivery, (iii) in the case of mailing, on the fifth business day
following that day on which the piece of mail containing such communication is posted and (iv) in the case of facsimile transmission, on the date of telephone confirmation of receipt. 
 (j) Entire Agreement. This Agreement constitutes the full and entire understanding and agreement of the parties with
regard to the subject matter hereof and supersedes all prior agreements and understandings among the parties with respect thereto. 
 [Signature pages follows] 
  

 15 

 IN WITNESS WHEREOF, the parties have executed this Fourth Amended and Restated
Investor Rights Agreement as of the date first written above. 
  

			
	COMPANY:
	
	BG MEDICINE, INC.
		
	By:	 	/s/ Pieter Muntendam
	Name:	 	Pieter Muntendam
	Title:	 	President and Chief Executive Officer
	
	HOLDERS:
	
	 GILDE EUROPE FOOD & AGRIBUSINESS
 FUND B.V.

		
	By:	 	/s/ Pieter van der Meer
	Name:	 	Pieter van der Meer
	Title:	 	Partner
		
	By:	 	/s/ Pieter Muntendam
	Name:	 	PIETER MUNTENDAM
		
	By:	 	/s/ Stelios Papadopoulos
	Name:	 	STELIOS PAPADOPOULOS
	
	WATERS TECHNOLOGIES CORPORATION
		
	By:	 	/s/ John Ornell
	Name:	 	John Ornell
	Title:	 	Senior Vice President, Chief Financial Officer

 Signature page to Fourth Amended and Restated Investor
Rights Agreement 

 IN WITNESS WHEREOF, the parties have executed this Fourth Amended and Restated
Investor Rights Agreement as of the date first written above. 
  

			
	HOLDERS:
	
	FLAGSHIP VENTURES:
	
	 NEWCOGEN GROUP LLC;
 NEWCOGEN EQUITY INVESTORS LLC;
 NEWCOGEN PE LLC;
 NEWCOGEN
ÉLAN LLC;
 ST NEWCOGEN LLC;
 NEWCOGEN LONG REIGN HOLDING LLC

	
	 Each by its Manager NewcoGen Group Inc.

		
	By:	 	/s/ Noubar Afeyan
		 	Noubar Afeyan
		 	President
	
	APPLIED GENOMIC TECHNOLOGY CAPITAL FUND, L.P.;
	AGTC ADVISORS FUND, L.P.
	
	 Each by its General Partner, AGTC Partners, L.P.
 By its General Partner, NewcoGen Group Inc.

		
	By:	 	/s/ Noubar B. Afeyan
		 	Noubar B. Afeyan
		 	President
	
	ONELIBERTY VENTURES 2000, L.P.;
	ONELIBERTY ADVISORS FUND 2000, L.P.
	Each by: OneLiberty Partners 2000, LLC,
		 	its General Partner
		
	By:	 	/s/ Noubar B. Afeyan
		 	Noubar B. Afeyan
		 	President

 Signature page to Fourth Amended and Restated Investor
Rights Agreement 

 IN WITNESS WHEREOF, the parties have executed this Fourth Amended and Restated
Investor Rights Agreement as of the date first written above. 
  

			
	KONINKLIJKE PHILIPS ELECTRONICS N.V.
		
	By:	 	/s/ Eric Coutinho
	Name:	 	Eric Coutinho
	Title:	 	General Secretary and Chief Legal Officer
	
	HUMANA INC.
		
	By:	 	/s/ Ralph M. Wilson
	Name:	 	Ralph M. Wilson
	Title:	 	Vice President and Assistant General Counsel
	
	SMALLCAP WORLD FUND, INC.
	 By Capital Research and Management Company,
 its investment adviser
 (shares in name of Clipperbay & Co., HG 22)

		
	By:	 	/s/ Catherine M. Ward
	Name:	 	Catherine M. Ward
	Title:	 	Senior Vice President
	
	LEGG MASON SPECIAL INVESTMENT TRUST, INC.
	(shares in name of Tidalwave & Co.)
		
	By:	 	/s/ Gregory Merz
	Name:	 	Gregory Merz
	Title:	 	Vice President
	
	GENERAL ELECTRIC PENSION TRUST
	 By: GE Asset Management Incorporated,
 its Investment Manager

		
	By:	 	/s/ Patrick M. McNeela
	Name:	 	Patrick M. McNeela
	Title:	 	Senior Vice President

 Signature page to Fourth Amended and Restated Investor
Rights Agreement 

 Schedule A 
 Preferred Stockholders 
 FLAGSHIP VENTURES: 

NEWCOGEN EQUITY INVESTORS LLC 
 NEWCOGEN-PE LLC

 NEWCOGEN-Elan LLC 
 NEWCOGEN-LONG
REIGN HOLDING 
 ST NEWCOGEN LLC 
 NEWCOGEN GROUP LLC 
 ONELIBERTY VENTURES 2000, L.P. 
 ONELIBERTY ADVISORS 2000, L.P. 
 APPLIED GENOMIC TECHNOLOGY CAPITAL FUND, L.P. 
 AGTC ADVISORS FUND, L.P. 
 GILDE EUROPE
FOOD & AGRIBUSINESS FUND B.V. 
 WATERS TECHNOLOGIES CORPORATION 
 PIETER MUNTENDAM 
 STELIOS PAPADOPOULOS 

 KONINKLIJKE PHILIPS ELECTRONICS N.V. 
 HUMANA INC. 
 SMALLCAP World Fund, Inc.
 (shares in name of Clipperbay & Co., HG 22) 
 LEGG MASON SPECIAL INVESTMENT TRUST, INC. 
 (shares in name of Tidalwave & Co.) 
 GENERAL ELECTRIC PENSION TRUST

 BG MEDICINE, INC. 
 INSTRUMENT OF ACCESSION TO 
 FOURTH AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 The undersigned, as a condition precedent to being granted certain rights with respect
to the undersigned’s shares of Preferred Stock, par value $.001 per share, of BG Medicine, Inc., a Delaware corporation (the “Company”); hereby agrees to be a party to and be bound by the Fourth Amended and Restated Investor Rights
Agreement dated as of July 10, 2008, as amended from time to time, by and among the Company and other parties thereto (the “Investor Rights Agreement”). Upon execution of this Instrument of Accession, the undersigned shall be deemed
to be a “Preferred Stockholder” for all purposes under the Investor Rights Agreement. 
 This Instrument of Accession
shall take effect and shall become an integral part of the Investor Rights Agreement with respect to the undersigned immediately upon execution and delivery by the undersigned and the Company of this Instrument. 
 IN WITNESS WHEREOF, this Instrument of Accession has been duly executed by the undersigned, as of the date below written. 
  

			
	PREFERRED STOCKHOLDER:
		
	By:	 	 
	Name:	 	
	Title:	 	
	Date:

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