Document:

[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

Exhibit 10.24  

First Amendment to Letter of Intent  

        This First Amendment (the "Amendment") to the letter agreement by and between the Affymax, Inc.
("Affymax"), a Delaware corporation located at 4001 Miranda Avenue, Palo Alto California, and American Peptide Company, Inc.
("APC") a California corporation with registered offices at 777 Evelyn Avenue, Sunnyvale, California, and dated of even date herewith
("Letter Agreement") is entered into this 9th day of October 2003. 

BACKGROUND 

        Affymax
and APC have entered into the Letter Agreement, which is incorporated herein by reference, whereunder Affymax and APC agreed to certain terms with respect to a process
development and supply relationship in which APC will manufacture and supply Affymax with Affymax's requirements for Affymax's proprietary peptide product Hematide through Phase II clinical trials.
The terms of the Letter Agreement relate to Hematide having a [*] polyethylene glycol
("[*] PEG"). 

        For
the purpose of enhancing the commercial potential of Hematide at an expedited pace, both parties desire to cooperate further in conducting manufacture, testing and release of
clinical grade (cGMP) Hematide which incorporates a [*]polyethylene glycol ("[*]
PEG") under the same terms as the Letter Agreement except as specifically modified herein. 

        Now,
therefore, in consideration of the mutual obligations set forth herein and of other valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Affymax and
APC agree as follows: 

AGREEMENT 

        The
parties agree that the following terms and modifications shall supercede the corresponding provisions in the Letter Agreement: 

        Affymax
and APC have decided to substitute Hematide containing [*] PEG
("[*] PEG Hematide") and designated as [*] which shall
be manufactured in place of Hematide containing [*] PEG  [*]. The [*] PEG Hematide shall be manufactured
using  [*] PEG obtained from Nektar per Affymax's request and shipped directly to APC. If APC receives at least 75-80 grams
of [*] PEG from Nektar prior to October 3, 2003, then APC shall release and deliver to Affymax on or before
November 28, 2003 a minimum of thirty (30) grams of Early Stage Drug Substance comprising gross weight of [*] PEG
Hematide. The Specifications for this Early Stage Drug Substance is described in the attached Exhibits A and B which supercede the corresponding Exhibits in the Letter Agreement. 

        Affymax
shall cause to be delivered to APC an additional shipment of Nektar PEG and, if delivered to APC by October 31, 2003, APC shall release and deliver a second batch of Early 

Stage
Drug Substance fulfilling the Affymax order for a total of one-hundred (100) grams total nine (9) weeks after APC's QA release of the  [*] PEG which shall result in product release and shipment
no later than twelve (12) weeks subsequent to
October 31, 2003. The cost per gram for Early Stage Drug Substance for the two batches totaling one-hundred (100) grams shall be  [*] for Early Stage Drug Substance conforming to the
Specifications. Affymax shall supply  [*] PEG to APC at a cost of [*] to be credited against
any future invoice from APC payable by Affymax. APC shall return any unused portion of the [*] PEG to Affymax after conjugation
is complete and shall receive a reciprocal credit from Affymax of $100 per gram for the unused PEG. 

        Affymax
agrees to reimburse APC for up to [*] of unused  [*] PEG (Sunbrite) and APC shall ship said [*] PEG to
Affymax prior to October 31, 2003. 

        This
document serves as authorization from Affymax for APC to utilize the Nektar [*] PEG as specified in the
current BPR for manufacture of the Early Stage Drug Substance. 

        IN
WITNESS THEREOF, the parties hereto have caused this Amendment to be executed by their respective duly authorized officers or representatives on the date first above written. 

	"AFFYMAX"

Affymax, Inc.	 	"APC"

American Peptide Company
	

By:	

/s/  ARLENE MORRIS      
	
 	

By:	

/s/  SHAWN LEE      

	Name:	Arlene M. Morris
	 	Name:	Shawn Lee

	Title:	President and CEO
	 	Title:	Chief Operating Officer

	Date:	October 9, 2003
	 	Date:	October 9, 2003

[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

Exhibits
A and B attached following 

Exhibit A  

Product  

	Product

Number
	 	Sequence
	 	Purity By

HPLC
	 	Quantity

Gross
	 	Price

(US$)
	 	Delivery (wks)

	323012	 	[*]	 	= or [*]	 	2 batches

total min 75g

to max 100g	 	[*]	 	[*]

Exhibit B  

Specifications for Release [*] Intermediate:  

	Attribute
 
	 	Specifications
	 	Test Methods

	[*]	 	[*]	 	[*]

Specifications for GMP Release [*]:  

	Attribute
 
	 	Specifications
	 	Test Methods

	[*]	 	[*]	 	[*]

Additional Specifications for [*] for Information Only:  

	Attribute
 
	 	Specifications
	 	Test Methods
	 	Cost

	[*]	 	[*]	 	[*]	 	[*]

[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

Exhibit 10.25  

[LETTERHEAD] 

March 24,
2006 

Chris
J. Bai, Ph.D.

President and CEO

American Peptide Company 1271 Avenida Chelsea

Vista, CA 92081

Re:
Clinical Supply Agreement 

Dear
Dr.Bai: 

        As
you know, American Peptide Company ("APC") has previously manufactured under contract (Letter Agreement dated 9 October 2003 and the Amendment thereof also dated 9
October 2003) on behalf of Affymax, Inc. ("Affymax") certain supplies of Affymax's lead compound, HematideTM. Since then our companies have been engaged in discussions
relating to a possible continued relationship for the contract manufacture of Hematide by APC. As an element of the evaluation of APC as a potential contract peptide manufacturer of Hematide, Affymax
desires to ensure that APC is capable of making and delivering Hematide in sufficient yields and purities, and at a satisfactory cost basis under appropriate current Good Manufacturing Practices
(cGMP), prior to Affymax determining
whether to enter into further discussions with APC relating to a commercial-scale development and supply agreement. In order to facilitate Affymax's evaluation of APC's capabilities, APC and Affymax
agree to enter into this Clinical Supply Agreement ("Agreement"), which shall constitute an extension and renewal of the Letter Agreement and Amendment thereof dated 9 October 2003, including
all terms and conditions therein except the delivery date(s), payments, specifications and amounts are modified as described below. 

        Under
this Agreement APC indicates its willingness to manufacture under cGMP a 100 gram lot of Hematide Active Pharmaceutical Ingredient (API) meeting the specifications incorporated as
attached hereto and deliver 100 grams of API to Affymax during [*] timeframe for evaluation and testing at Affymax's sole
discretion. In order to facilitate 

1

 

timely
acquisition of certain raw materials for the synthesis of 100 grams of API by APC prior to the execution, if any, of a subsequent development and supply agreement, Affymax hereby agrees to
provide APC with [*], which shall be fully creditable against any future payments due to APC. 

        The
manufacturing batch production record (BPR) written by APC for the proposed 100 gram lot of API shall follow the APC BPR previously established for the manufacture of API with
changes as provided by Affymax and as agreed to by the parties. APC shall retain the executed BPR and all supporting records for a period not less than 7 years. Upon request from Affymax, APC
shall provide Affymax with a photocopy of the executed BPR used to manufacture the 100 gram lot. The 100 gram lot will be invoiced to Affymax at a cost of  [*]. Affymax will provide sufficient PEG
reagent to APC at no cost to APC for APC use in the manufacturing of 100 grams of API.
Upon APC's release and delivery of the 100 gram lot of API to Affymax under this Agreement, APC shall also provide to Affymax at such time a report ("Development Report") describing the preparation of
the lot to include the details of the manufacturing process, step yields, API control and in-process analytical methods, and method validation procedures used to make and test the API lot
and sufficient for Affymax to prepare Chemistry, Manufacturing and Controls documentation in accordance with cGMP Guidelines for Industry as published by the FDA. 

        Subsequent
to acceptance of the 100 grams of API by Affymax, APC agrees to manufacture under cGMP a 500 gram lot of API meeting the specification incorporated as attached hereto and
deliver 500 grams of API to Affymax during [*] timeframe for evaluation and testing at Affymax's sole discretion. In order to
facilitate timely acquisition of certain raw materials for the synthesis of 500 grams of API by APC, Affymax hereby agrees to provide APC with  [*] U.S. Dollars [*], which shall be fully creditable
against any future payments due to APC. 

        The
manufacturing BPR written by APC for the proposed 500 gram lot of API shall follow the aforementioned APC BPR for the manufacture of API with changes as provided by Affymax and as
agreed to by the parties. APC shall retain the executed BPR and all supporting records for a period not less than 7 years. Upon request from Affymax, APC shall provide Affymax with a photocopy
of the executed BPR used to manufacture the 500 gram lot. The 500 gram lot will be a single lot from a manufacturing campaign separate from that used to generate the 100 gram lot and shall be invoiced
to Affymax at a cost of [*]. APC will purchase from Affymax at a cost of  [*] sufficient PEG for the manufacturing of 500 grams of API. Upon APC's release
and delivery of the 500 gram lot of API to
Affymax under this Agreement, APC shall also provide to Affymax at such time a Development Report describing the preparation of the lot to include the details of the manufacturing process, step
yields, API control and in-process analytical methods, and method validation procedures used to make and test the API lot and sufficient for Affymax to prepare Chemistry, Manufacturing and
Controls 

[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

2

 

documentation
in accordance with cGMP Guidelines for Industry as published by the FDA 

        Nothing
in this letter agreement shall obligate either party to negotiate further with the other party nor to enter into either a subsequent development and supply agreement or a long
term commercial manufacturing agreement. Each party shall be free to use their sole and unencumbered discretion in determining whether or not to negotiate and/or execute any other subsequent agreement
with the other party. Affymax and APC may individually elect to not enter into a subsequent agreement with the other party for any reason or for no reason whatsoever. Nor shall there be any duty for
any party to disclose to the other party its basis for a determination not to pursue or consummate a subsequent agreement. 

        This
Agreement is effective as of the date of the last-to-sign party indicated below and memorializes our joint understanding of this matter. This letter
agreement shall be enforceable even if one or more provisions herein are found by a court of competent jurisdiction to be unenforceable. With regard to any disputes between the parties regarding this
matter, the parties agree to submit to jurisdiction in the State of California and under California law. Any modifications to the terms of this letter agreement shall be in writing and executed by
both parties hereto if each party agrees to such modification in their sole discretion. 

        Please
have an authorized officer of APC execute on behalf of APC on the indicated signature and date lines below if APC accepts the terms of this letter agreement. 

	 
	 
	 	 
	 

	On Behalf of Affymax, Inc.	 	On Behalf of American Peptide Company
	

Signed:	

/s/  ROBERT B. NASO      
	
 	

Signed:	

/s/  CHRIS J. BAI      

	Name:	Robert B. Naso
	 	Name:	Chris J. Bai

	Title:	Executive Vice President
	 	Title:	President and CEO

	Date:	March 24, 2006
	 	Date:	March 27, 2006

[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES
AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

3

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