Document:

<PAGE>
                                                                   EXHIBIT 10.30
<TABLE>
<S><C>
===================================================================================================================================
                                                                    1. CONTRACT ID NO.                               PAGE OF PAGES
     AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT                N01-HB-07148                                    1       4
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2. AMENDMENT/MODIFICATION NO.     3. EFFECTIVE DATE        4. REQUISITION/PURCHASE REQ. NO.         5. PROJECT NO. (If applicable)
           One (1)                   See Block 16C.                      N/A
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6. ISSUED BY                  CODE                        7. ADMINISTERED BY (If other than Item 6)            CODE
                                   --------------                                                                   --------------
National Institutes of Health                             BDR Contracts Section, COB, DEA, NHLBI
National Heart, Lung, and Blood Institute                 AIIN: 268907148
6701 Rockledge Drive (RKL2), MSC 7902                     OMB No. 0990-0115
Bethesda, MD 20892-7902
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8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)     (X) 9A. AMENDMENT OF SOLICITATION NO.
                                                                                ---
                                                                                    -----------------------------------------------
                                                                                    9B. DATED (SEE ITEM 13)
Gen-Probe, Inc.
10210 Genetic Center Drive                                                       --------------------------------------------------
San Diego, California 92121-4362                                                    10A. MODIFICATION OF CONTRACT/ORDER
                                                                                         NO.
                                                                                             N01-HB-07148
                                                                                (X) -----------------------------------------------
--------------------------------------------------------------------------------    10B. DATED (SEE ITEM 13)
CODE                                    FACILITY CODE                                        January 1, 2000
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                                        11. THIS ITEM APPLIES TO AMENDMENTS OF SOLICITATIONS
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[ ] The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers
                                                                        [  ] is extended, [  ] is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of
the following methods:

(a) By completing Items 8 and 15, and returning ___ copies of the amendment; (b) By acknowledging receipt of this amendment on each
copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment
numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE
SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted,
such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this
amendment, and is received prior to the opening hour and date specified.
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12. ACCOUNTING AND APPROPRIATION DATA (If required)
O.C. 25.55     Doc. No. 300N1HB07148A     DUNS 115337123     EIN: 1-33-0044608-A2
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                                  13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
                                      IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.
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[X]   A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT
----     ORDER NO. IN ITEM 10A.

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      B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office,
         appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

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     C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
 X   FAR 1.602-1 and by mutual agreement
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     D. OTHER (Specify type of modification and authority)

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E. IMPORTANT: Contractor [ ] is not, [X] is required to sign this document and return 2 copies to the issuing office.
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14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter
    where feasible.)

PURPOSE: To revise the cost-sharing agreement of the contract and amend the statement of work to reflect the contractor's
development of a "Triplex" assay to detect HIV-1, HCV, and HBV in a single assay format.

CONTRACT AMOUNT: $7,583,879 (UNCHANGED)

EXPIRATION DATE: December 31, 2002 (UNCHANGED)

CONTRACT TYPE: Cost-Reimbursement

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains
unchanged and in full force and effect.
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15A. NAME AND TITLE OF SIGNER (Type or print)               16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  Henry L. Nordhoff, President & CEO                                              Lynda A. Bindseil
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15B. CONTRACTOR/OFFEROR                 15C. DATE SIGNED    16B. UNITED STATES OF AMERICA                         16C. DATE SIGNED

   /s/ HENRY L. NORDHOFF                     6-23-00        BY /s/ LYNDA A. BINDSEIL                                 6/28/00
   ----------------------------------------                    ----------------------------------------
   (Signature of person authorized to sign)                    (Signature of Contracting Officer)
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NSN 7540-01-152-8070                                         30-105                                   STANDARD FORM 30 (REV. 10-83)
PREVIOUS EDITION UNUSABLE                                                                                         PRESCRIBED BY GSA
                                                                                                                FAR (48 CFR) 53.243
</TABLE>
<PAGE>
Gen-Probe, Inc.
Contract N01-HB-07148
Modification No. 1

THE GOVERNMENT AND THE CONTRACTOR MUTUALLY AGREE AS FOLLOWS:

1)      ARTICLE B.2. ESTIMATED COST, is hereby replaced as follows:

        "ARTICLE B.2. ESTIMATED COST

        a.      This is a cost-sharing contract. The total estimated cost of
                performing the work under this contract is $13,367,620. For
                further provisions regarding the specific cost-sharing
                arrangement, see ARTICLE B.4. ADVANCE UNDERSTANDINGS.

        b.      For purpose of the clause of the General Clauses entitled
                LIMITATION OF FUNDS, the total estimated cost to the Government
                is $7,583,879.

        c.      Total funds currently available for payment and allotted to this
                contract are $4,652,739. For further provisions on funding, see
                the LIMITATION OF FUNDS clause referenced in Part II, ARTICLE
                I.2. Authorized Substitutions of Clauses.

        d.      It is estimated that the amount currently allotted will cover
                performance of the contract through November 30, 2001. The
                Contracting Officer may allot additional funds to the contract
                without the concurrence of the Contractor.

        e.      Future increments to be allotted to this contract are estimated
                as follows:

<TABLE>
<CAPTION>
                     Period                            Amount
                     ------                            ------
              <S>                                     <C>
              12/01/O1 -12/31/02                      $2,930,140"
</TABLE>

2)      ARTICLE B.4. ADVANCE UNDERSTANDINGS, paragraphs c. and d. are revised
        and replaced as follows:

"c.     COST SHARING

        (1)     This is a cost-sharing contract. Monies shall be provided for
                the total cost of performance from the National Institutes of
                Health, National Heart, Lung, and Blood Institute and Gen-Probe
                Incorporated.

        (2)     The Government shall provide monies in an amount not to exceed
                $7,583,879. The Contractor's share is estimated at $5,783,741 OR
                43.3% of the total estimated cost set forth in ARTICLE B.2.
                ESTIMATED COST, paragraph a.

        (3)     The Contractor shall maintain records of all contract costs
                (including costs claimed by the Contractor as being its share)
                and such records shall be subject to the Audit and

                                   Page 2 of 4
<PAGE>

Gen-Probe, Inc.
Contract N01-HB-07148
Modification No. 1

                Records clause of the General Clauses.

        (4)     Costs contributed by the Contractor shall not be charged to the
                Government under any other contract, grant, or cooperative
                agreement (including allocation to other grants, contracts, or
                cooperative agreements as part of an independent research and
                development program). The Contractor shall report the
                organization's share of the costs on its invoices to the
                Government as referenced in ARTICLE B.4.d.(1)."

d.      INVOICES - COST AND PERSONNEL REPORTING, AND VARIANCES FROM THE
        NEGOTIATED BUDGET

        (1)     The contractor agrees to provide a detailed breakdown on
                invoices of the following cost categories:

                (a) Direct Labor - List individuals by name, title/position,
                hourly/annual rate, level of effort, and amount claimed.

                (b) Materials

                (c) Travel

                (d) Subcontractor Westat, Inc. - Attach subcontractor's
                invoice(s).

                (e) Specimen Procurement

                (f) Development Lots

                (g) Total Direct Cost

                (h) Overhead + G&A + Fringe Benefits (at) 125% of Direct Labor

                (i) Total Billing Cost (NHLBI)

                (j) Direct Costs Not Billed to NHLBI

                (k) Development Lots

                (l) Clinical Trial Reagents

                (m) Total Gen-Probe Share

                Monthly invoices must include the cumulative total expenses to
                date, adjusted (as applicable) to show any amounts suspended by
                the Government.

        (2)     The contractor agrees to immediately notify the contracting
                officer in writing if there is an anticipated overrun (any
                amount) or unexpended balance (greater than 10 percent) of the
                amount allotted to the contract, and the reasons for the
                variance. Also refer to the requirements of the Limitation of
                Funds and Limitation of Cost Clauses in the contract."

3)      ARTICLE C.1. STATEMENT OF WORK, PHASE I: Preclinical Studies/Test
        Refinement, is revised to read as follows:

        "PHASE I: Preclinical Studies/Test Refinement

                                  Page 3 of 4
<PAGE>

Gen-Probe, Inc.
Contract N01-HB-07148
Modification No. 1

        1.      Refine a procedure for screening of organ donors for blood-borne
                viruses. The contractor must:

                a.      Demonstrate that the organ donor assay detects minimal
                        amounts of viral nucleic acids (RNA and/or other viral
                        nucleic acids that appear at the same time or before the
                        earliest appearance of viral RNA circulating in plasma)
                        specific for HIV-1, HCV and HBV. If specimens other than
                        blood are to be used, determine the best tissue to use
                        as a test material source.

                b.      Have and describe plans to adapt the test methods to a
                        multiplexing format that will detect multiple
                        blood-borne viruses (two or more viruses) in the same
                        test. The three highest priority viruses to be detected
                        are HIV-1, HCV and HBV. The testing method(s) proposed
                        must be able to detect each of these viruses, in
                        multiplexing format. If additional viruses are included
                        in the test system (e.g., HIV-2, etc.), they are also to
                        be incorporated into a multiplex format."

4)      ARTICLE C.1. STATEMENT OF WORK, paragraph b. is replaced to read as
        follows:

        "b.     The following described document is hereby made a part of this
                contract excluding any references to Montalbano Development,
                Incorporated (MDI): Pages 3-1, 4-1, 4- 6 (starting with
                paragraph 4.b.1), 4-7, 4-8 (stopping at paragraph 4.b.1.1), 4-19
                (starting with paragraph 4.b.2) thru page 4-18 (stopping at
                paragraph 4.c) of the contractor's Technical proposal dated
                February 10, 1999; subsequent written responses dated June 22,
                1999; the Final Proposal Revisions dated August 18, 1999, and
                Gen-Probe's letter dated May 10, 2000 which outlines the
                contractor's revised development plan for its NAT Blood Virus
                Organ Donor Assay."

                                  Page 4 of 4<PAGE>
                                                                   EXHIBIT 10.31
<TABLE>
<S><C>
===================================================================================================================================
                                                                    1. CONTRACT ID NO.                               PAGE OF PAGES
     AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT                N01-HB-07148                                    1       2
-----------------------------------------------------------------------------------------------------------------------------------
2. AMENDMENT/MODIFICATION NO.     3. EFFECTIVE DATE        4. REQUISITION/PURCHASE REQ. NO.         5. PROJECT NO. (If applicable)
           Two (2)                   See Block 16C.                      N/A
-----------------------------------------------------------------------------------------------------------------------------------
6. ISSUED BY                  CODE                        7. ADMINISTERED BY (If other than Item 6)            CODE
                                   --------------                                                                   --------------
National Institutes of Health                             BDR Contracts Section, COB, DEA, NHLBI
National Heart, Lung, and Blood Institute                 AIIN: 268907148
6701 Rockledge Drive (RKL2), MSC 7902                     OMB No. 0990-0115
Bethesda, MD 20892-7902
-----------------------------------------------------------------------------------------------------------------------------------
8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)     (X) 9A. AMENDMENT OF SOLICITATION NO.
                                                                                ---
                                                                                    -----------------------------------------------
                                                                                    9B. DATED (SEE ITEM 13)
Gen-Probe, Inc.
10210 Genetic Center Drive                                                       --------------------------------------------------
San Diego, California 92121-4362                                                    10A. MODIFICATION OF CONTRACT/ORDER
                                                                                         NO.
                                                                                             N01-HB-07148
                                                                                (X) -----------------------------------------------
--------------------------------------------------------------------------------    10B. DATED (SEE ITEM 13)
CODE                                    FACILITY CODE                                        January 1, 2000
-----------------------------------------------------------------------------------------------------------------------------------
                                        11. THIS ITEM APPLIES TO AMENDMENTS OF SOLICITATIONS
-----------------------------------------------------------------------------------------------------------------------------------
[ ] The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers
                                                                        [  ] is extended, [  ] is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of
the following methods:

(a) By completing Items 8 and 15, and returning ___ copies of the amendment; (b) By acknowledging receipt of this amendment on each
copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment
numbers. FAILURE OF YOUR ACKNOWLEDGMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE
SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted,
such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this
amendment, and is received prior to the opening hour and date specified.
-----------------------------------------------------------------------------------------------------------------------------------
12. ACCOUNTING AND APPROPRIATION DATA (If required)
O.C. 25.55     Doc. No. 300N1HB07148A     DUNS 115337123     EIN: 1-33-0044608-A2
-----------------------------------------------------------------------------------------------------------------------------------
                                  13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,
                                      IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.
-----------------------------------------------------------------------------------------------------------------------------------
[X]   A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT
----     ORDER NO. IN ITEM 10A.

-----------------------------------------------------------------------------------------------------------------------------------
      B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office,
         appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

-----------------------------------------------------------------------------------------------------------------------------------
     C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
 X   FAR 1.602-1
-----------------------------------------------------------------------------------------------------------------------------------
     D. OTHER (Specify type of modification and authority)

-----------------------------------------------------------------------------------------------------------------------------------
E. IMPORTANT: Contractor [ ] is not, [X] is required to sign this document and return 2 copies to the issuing office.
-----------------------------------------------------------------------------------------------------------------------------------
14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter
    where feasible.)

PURPOSE: To update Section H to include the requirement for contractor education in the protection of human research participants.

CONTRACT AMOUNT: $7,583,879 (UNCHANGED)

EXPIRATION DATE: December 31, 2002 (UNCHANGED)

CONTRACT TYPE: Cost-Reimbursement

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains
unchanged and in full force and effect.
-----------------------------------------------------------------------------------------------------------------------------------
15A. NAME AND TITLE OF SIGNER (Type or print)               16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

  Henry L. Nordhoff, President & CEO                                              Lynda A. Bindseil
-----------------------------------------------------------------------------------------------------------------------------------
15B. CONTRACTOR/OFFEROR GEN-PROBE INC.  15C. DATE SIGNED    16B. UNITED STATES OF AMERICA                         16C. DATE SIGNED

   /s/ HENRY L. NORDHOFF                     9-20-00        BY /s/ LYNDA A. BINDSEIL                                 9/21/00
   ----------------------------------------                    ----------------------------------------
   (Signature of person authorized to sign)                    (Signature of Contracting Officer)
-----------------------------------------------------------------------------------------------------------------------------------
NSN 7540-01-152-8070                                         30-105                                   STANDARD FORM 30 (REV. 10-83)
PREVIOUS EDITION UNUSABLE                                                                                         PRESCRIBED BY GSA
                                                                                                                FAR (48 CFR) 53.243
</TABLE>
<PAGE>

CONTRACT NO. N01-HB-07148
MODIFICATION NO. 02
PAGE 2

THE GOVERNMENT AND THE CONTRACTOR MUTUALLY AGREE AS FOLLOWS:

1.    ARTICLE C.2. - REPORTING REQUIREMENTS, paragraph a. Quarterly Progress
      Report, is revised to add the following sentence:

      "The contractor must comply with ARTICLE H.12. in providing a description
      of education in the protection of human subjects in its next report due on
      or after October 1, 2000."

2.    ARTICLE H.12., is hereby added to Section H of the contract as follows:

      "ARTICLE H.12. REQUIRED EDUCATION IN THE PROTECTION OF HUMAN RESEARCH
      PARTICIPANTS

      NIH policy requires education on the protection of human subject
      participants for all investigators receiving NIH contract awards for
      research involving human subjects. For a complete description of the NIH
      Announcement on required education in the protection of human subject
      participants, the contractor should access the NIH Guide for Grants and
      Contracts Announcement dated June 5, 2000 at the following website:
      http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html. The
      information below is a summary of the NIH Policy Announcement:

      The following information is to be furnished in the first progress report
      or with the first deliverable submitted to the Government after October 1,
      2000, whichever occurs earlier: The contractor is required to submit a
      description of education in the protection of human subjects that has been
      completed by the principal investigator and any other individuals,
      including any subcontractors or consultants, who are responsible for the
      design and conduct of the research under the contract.

      Curricula that are readily available and meet the educational requirement
      include the NIH on-line tutorial, titled "Protection of Human Research
      Subjects: Computer-Based Training for Researchers," available at
      http://ohsr.od.nih.gov/cbt. This site may be downloaded at no cost and
      modified for use by the contractor, if desired. In addition, the
      University of Rochester has made available its training program for
      individual investigators, and completion of this program will also satisfy
      the educational requirement. The University of Rochester manual can be
      obtained through Centerwatch, Inc. at
      http://www.centerwatch.com/order/pubs_profs_protect.html. If an
      institution has already developed educational programs on the protection
      of research participants, completion of these programs will also satisfy
      the educational requirement.

      In addition, prior to the substitution of the principal investigator or
      any other individuals responsible for the design and conduct of the
      research under the contract, the contractor shall provide information in
      writing to the contracting officer describing the education in the
      protection of human subjects that has been completed by the replacement."

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