Document:

Exhibit 10.1

 

Amendment to Amended and Restated 2012
Equity Incentive Plan

 

WHEREAS, DarioHealth
Corp. (the “Company”) maintains the DarioHealth Corp.’s Amended and Restated 2012 Equity Incentive Plan (the
“Incentive Plan”);

 

WHEREAS, the
Board of Directors (the “Board”) and the Compensation Committee of the Board has determined that it is in the best
interests of the Company to amend the Incentive Plan to increase the maximum number of shares of the Company’s common stock
authorized to be issued under the Incentive Plan by 1,500,000, from 3,873,000 to 5,373,000; and

 

WHEREAS, pursuant
to Section 13 of the Incentive Plan, an amendment that materially increases the aggregate number of shares that may be issued under
the Incentive Plan generally must be approved by a majority of votes cast by the stockholders of the Company in accordance with
applicable stock exchange rules.

 

NOW, THEREFORE,
effective as of the date of approval by a majority of votes cast by the stockholders of the Company in accordance with applicable
stock exchange rules, the Incentive Plan is hereby amended in the following particulars:

 

	 	1.	Section 4(a) of the Incentive Plan is deleted in its entirety and replaced with the following:

 

Share Reserve. Subject to
the provisions of Section 11 relating to adjustments upon changes in Common Stock, the Common Stock that may be issued pursuant
to Awards shall not exceed in the aggregate of 5,373,000 shares of Common Stock. During the terms of the Awards, the Company shall
keep available at all times the number of shares of Common Stock required to satisfy such Awards.

 

	 	2.	In all other respects the Incentive Plan shall remain unchanged and in full force and effect.Exhibit
4.8

 

FORM
OF NON-TRANSFERABLE SUBSCRIPTION RIGHTS CERTIFICATE

 

	RIGHTS
    CERTIFICATE # [______]	NUMBER
    OF RIGHTS: [______]

 

THE
TERMS AND CONDITIONS OF THE RIGHTS OFFERING ARE SET FORTH IN THE COMPANY’S PROSPECTUS DATED _______   ___,
2018, AS AMENDED (THE “PROSPECTUS”) AND ARE INCORPORATED HEREIN BY REFERENCE. COPIES OF THE PROSPECTUS ARE
AVAILABLE UPON REQUEST FROM MORROW SODALI LLC, THE INFORMATION AGENT.

 

PAVMED
INC.

(Incorporated
under the laws of the State of Delaware)

 

SUBSCRIPTION
RIGHTS CERTIFICATE

 

Evidencing
non-transferable Subscription Rights to purchase Units, each Unit consisting of one share of our common stock and one Series Z
Warrant

Subscription
Price: $2.25 per Unit

 

THE
SUBSCRIPTION RIGHTS WILL EXPIRE IF NOT EXERCISED ON OR BEFORE 5:00 P.M., EASTERN TIME,

ON
_______ __, 2018 (THE “EXPIRATION DATE”) 

 

SUBJECT
TO EXTENSION OR EARLIER TERMINATION.

 

THIS
CERTIFIES THAT:

 

The
registered owner whose name is inscribed hereon is the owner of the number of subscription rights (“Subscription Rights”)
set forth above (subject to the pro rata reductions as described in the Prospectus resulting from the Subscription Cap (as defined
below)). Each Subscription Right entitles the holder thereof to subscribe for and purchase (the “Basic Subscription Right”)
one unit at a price of $2.25 per Unit (the “Subscription Price”), pursuant to a rights offering (the “Rights
Offering”), on the terms and subject to the conditions set forth in the Prospectus including the fact that PAVmed Inc.
(the “Company”) will only accept subscriptions for 9,000,000 units (the “Subscription Cap”).
Each unit, which the Company refers to as a “Unit” consists of one share of our common stock, par value of $0.001,
and one Series Z Warrant. Each Series Z Warrant will be exercisable for one share of our common stock, par value of $0.001. If
the Units do not qualify for listing on the Nasdaq Capital Market , or if the Company, at any time prior to the Expiration
Date, elects to exercise its Unlisted Unit Right (as defined in the Prospectus), only the shares of common stock and Series
Z Warrants will issue at the same subscription price per Unit. Holders who fully exercise their Basic Subscription Rights are
entitled to subscribe for additional Units that remain unsubscribed for as a result of any unexercised Basic Subscription Rights
pursuant to the terms and conditions of the Rights Offering (including the pro rata reductions described in the Prospectus resulting
from the Subscription Cap) at the Subscription Price (the “Over-subscription Privilege”). The Subscription
Rights represented by this Subscription Rights Certificate may be exercised by completing the appropriate forms on the reverse
side hereof and by returning the full payment of the subscription price for each Unit. If the Company is unable to issue the subscriber
the full amount of Units requested, the Subscription Agent will return to the subscriber any excess funds submitted as soon as
practicable, without interest or deduction.

This
Subscription Rights Certificate is not valid unless countersigned by Continental Stock Transfer & Trust Company, the Subscription
Agent.

 

WITNESS
the seal of PAVmed Inc. and the signatures of its duly authorized officers.

 

Dated:
 _____  __, 2018

 

	Lishan
    Aklog, M.D.	 	Dennis M McGrath 
	Chairman
    & Chief Executive Officer	 	Executive Vice President Chief Financial Office Corporate Secretaryr
	 	 	 	 
	 	 	COUNTERSIGNED AND REGISTERED:
	 	 	 	 
	 	 	By:
    	 
	 	 		Continental
    Stock Transfer & Trust Company

 

    	 	 	 

    	 

    

 

FORM
ELECTION TO PURCHASE

 

PLEASE
PRINT ALL INFORMATION CLEARLY AND LEGIBLY.

 

The
registered holder of this Subscription Rights Certificate is entitled to exercise the number of Subscription Rights shown in the
upper right hand corner of the Subscription Rights Certificate and may subscribe for additional Units upon the terms and conditions
specified in the Prospectus. The undersigned hereby represents, in connection with this election, that the undersigned has not
since the Record Date (as defined in the Prospectus) entered into any short sale or similar transaction with respect our common
stock. The undersigned hereby notifies the Subscription Agent of its irrevocable election to subscribe for Units in the following
amounts. To subscribe for Units pursuant to your Basic Subscription Right, please complete lines (a) and (c) below. To subscribe
for additional Units pursuant to your Over-subscription Privilege, please also complete line (b).

 

	(a)	EXERCISE
    OF BASIC SUBSCRIPTION RIGHT:

 

	Basic Subscription Right:	 	X	 	$	2.25	 	 	=	 	$		 
	Number of Units	 	 	 	 	Subscription price	 	 	 	 	 	Payment enclosed	 

 

	(b)	EXERCISE
    OF OVER-SUBSCRIPTION PRIVILEGE: If you have exercised your Basic Subscription Right in full, you may subscribe for additional
    Units pursuant to your Over-subscription Privilege

 

	Over-Subscription Privilege:	 	X	 	$	2.25	 	 	=	 	$		 
	Number of Units	 	 	 	 	Subscription price	 	 	 	 	 	Payment enclosed	 

 

	(c)	TOTAL
    AMOUNT OF PAYMENT ENCLOSED $

 

	(d)	IF
    YOU SPOKE WITH A BROKER WHO SOLICITED SUCH EXERCISE, PLEASE INDICATE THE NAME OF THE PERSON YOU SPOKE WITH: _____________

 

	METHOD
    OF PAYMENT (CHECK ONE):	 	[  ]	 	CERTIFIED
    CHECK DRAWN ON A U.S. BANK, payable to “Continental Stock Transfer & Trust Company, as Subscription Agent for PAVmed
    Inc.”
	 	 	 
	 	 	[  ]	 	Wire
    transfer of immediately available funds directly to the account maintained by Continental Stock Transfer & Trust Company,
    as Subscription Agent, for purposes of accepting subscriptions in this Rights Offering at JP Morgan Chase Bank, N.A ,
    ABA # 021-000-021 , Account # 475 473213 FBO PAVmed Inc., with reference to the name of the Subscription
    Rights holder.
	 	 	 
	 	 	[  ]	 	U.S.
    POSTAL MONEY ORDER, payable to “Continental Stock Transfer & Trust Company, as Subscription Agent PAVmed Inc.”
	 	 	 
	 	 	[  ]	 	UNCERTIFIED
    PERSONAL CHECK, payable to “Continental Stock Transfer & Trust Company, as Subscription Agent for PAVmed Inc.”
    (which must clear before the Expiration Date to be considered a valid form of payment; please see Prospectus and Instructions)

 

I
acknowledge receipt of the Prospectus in connection with the Rights Offering and agree to its terms. I agree to cooperate with
the Company and provide to the Company any and all information requested by the Company in connection with the exercise of the
Subscription Rights.

 

 

	Signature(s)
    of Subscriber(s)	 	Signature(s)
    of Subscriber(s)
	 	 	 
	Address:	 	Address:

 

IMPORTANT:
THE SIGNATURE(S) MUST CORRESPOND IN EVERY PARTICULAR, WITHOUT ALTERATION, WITH THE NAME(S) AS PRINTED ON THE FRONT OF THIS RIGHTS
CERTIFICATE. If signature is by trustee(s), executor(s), administrator(s), guardian(s), attorney(s)-in-fact, officer(s) of
a corporation or another acting in a fiduciary or representative capacity, please print name and title of authorized signer.

 

    	 	 	 

    	 

    

 

FOR
INSTRUCTIONS ON THE USE OF PAVMED INC. SUBSCRIPTION RIGHTS CERTIFICATES, CONSULT MORROW SODALI LLC., THE INFORMATION AGENT, AT:

 

Morrow
Sodali LLC

470
West Avenue

Stamford,
Connecticut 06902

Stockholders
please call toll-free: (800) 662-5200

Banks
and Brokerage Firms please call: (203) 658-9400

Email:
PAVM.info@morrowsodali.comExhibit
4.9

 

	NUMBER	 	UNITS
	 	 	 
	U-__________	 	 
	 	 	 
	 	 	 
	SEE
    REVERSE FOR CERTAIN DEFINITIONS	 	 

 

 

INCORPORATED
UNDER THE LAWS OF DELAWARE

 

CUSIP
70387R 304

 

UNITS
CONSISTING OF ONE SHARE OF COMMON STOCK AND

ONE
SERIES Z WARRANT

 

THIS
CERTIFIES THAT ________________________ is the owner of _______________ Units.

 

Each Unit (“Unit”)
consists of one (1) share of common stock, par value $.001 per share (“Common Stock”), of PAVmed Inc., a Delaware
corporation (the “Company”), and one (1) Series Z Warrant (the “Series Z Warrant(s)”). Each Series Z Warrant
entitles the holder to purchase one share of Common Stock for $1.60 per share from the date the Series Z Warrant is issued
through its expiration on April 30, 2024, or earlier upon certain redemption provisions. If the Units qualify for listing on the
Nasdaq Capital Market (“Nasdaq”) and provided that the Company has not elected to exercise its Unlisted Unit Right
(as defined in the Company’s Prospectus dated ________ __, 2018), the Common Stock and Series Z Warrant(s) comprising
the Unit(s) will not trade as a separate security for up to ninety days after the date of issuance. If the Units do not qualify
for listing on Nasdaq, the Common Stock and Series Z Warrants will be issued as separate securities and will separately trade
upon issuance. The terms of the Series Z Warrants are governed by a Warrant Agreement, dated as of April 5, 2018, between the
Company and Continental Stock Transfer & Trust Company, as Warrant Agent, and are subject to the terms and provisions contained
therein, all of which terms and provisions the holder of this certificate consents to by acceptance hereof. Copies of the Warrant
Agreement are on file at the office of the Warrant Agent at 1 State Street Plaza, 30th Floor, New York, New York 10004,
and are available to any Series Z Warrant holder on written request and without cost.

 

This
certificate is not valid unless countersigned by the Transfer Agent and Registrar of the Company.

 

Witness
the facsimile seal of the Company and the facsimile signatures of its duly authorized officers.

 

	Dated:

                                                                                 
		 
	CHAIRMAN		SECRETARY

 

    	 	 	 

    	 

    

 

PAVmed
Inc.

 

The
Company will furnish without charge to each shareholder who so requests, a statement of the powers, designations, preferences
and relative, participating, optional or other special rights of each class of stock or series thereof of the Company and the
qualifications, limitations, or restrictions of such preferences and/or rights.

 

The
following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were
written out in full according to applicable laws or regulations:

 

	TEN
    COM –	as
    tenants in common	UNIF
    GIFT MIN ACT -	_____
    Custodian ______
	TEN
    ENT –	as
    tenants by the entireties	 	(Cust)	(Minor)

	JT
    TEN –	as
    joint tenants with right of survivorship	under
    Uniform Gifts to Minors
	 	and
    not as tenants in common	Act
    ______________
	 	 	 	(State)	 

 

Additional
Abbreviations may also be used though not in the above list.

 

For
value received, ___________________________ hereby sell, assign and transfer unto

 

	PLEASE
    INSERT SOCIAL SECURITY OR OTHER	 	 
	IDENTIFYING
    NUMBER OF ASSIGNEE	 	 
	 	 	 
	 	 	 
	 	 	 

 

 

 

(PLEASE
PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

 

 

 

 

	 	Units

 

represented
by the within Certificate, and do hereby irrevocably constitute and appoint

 

	 	Attorney

to
transfer the said Units on the books of the within named Company will full power of substitution in the premises.

 

	Dated
    	 	 

 

	 	 	 
	 	Notice:	The
    signature to this assignment must correspond with the name as written upon the face of the certificate in every particular,
    without alteration or enlargement or any change whatever.

 

Signature(s)
Guaranteed:

	 	 

THE
SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION

(BANKS,
STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH

MEMBERSHIP
IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM,

PURSUANT
TO S.E.C. RULE 17Ad-15).

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