Document:

EX-10.14

 Exhibit 10.14 

CONSULTING AGREEMENT 
 This Consulting
Agreement (the “Agreement”) is made effective as of May 7, 2018 (the “Effective Date”), by and between Tycho Therapeutics, Inc., a Delaware corporation, with its principal place of business being [****] (the
“Company”) and Danforth Advisors, LLC, a Massachusetts limited liability corporation, with its principal place of business being [****] (“Danforth”). The Company and Danforth are herein sometimes referred to individually as a
“Party” and collectively as the “Parties.” 
 WHEREAS, the Company possesses
know-how and proprietary technology related to the discovery and development of therapeutics the utilize chimeric autoantibody/alloantibody receptor T-cells (CAAR-Ts); and 
 WHEREAS, Danforth has expertise in financial and corporate operations and strategy; and

 WHEREAS, Danforth desires to serve as an independent consultant for the purpose of providing the Company with certain strategic and
financial advice and support services, as more fully described in Exhibit A attached hereto, (the “Services”); and 

WHEREAS, the Company wishes to engage Danforth on the terms and conditions set forth herein. 

NOW THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which are hereby acknowledged,
the Parties agree and covenant as follows. 
  

	1.	 Services of Consultant. Danforth will assist the Company with matters relating to the Services. The
Services are more fully described in Exhibit A attached hereto. Danforth and the Company will review the Services on a monthly basis to prioritize and implement the tasks listed on Exhibit A. 

 

	2.	 Compensation for Services. In full consideration of Danforth’s full, prompt and faithful
performance of the Services, the Company shall compensate Danforth a consulting fee more fully described in Exhibit A (the “Consulting Fee”). Danforth shall, from time to time, but not more frequently than once per calendar
month, invoice the Company for Services rendered, and such invoice will be paid upon thirty (30) days of receipt. Each month the Parties shall evaluate jointly the current fee structure and scope of Services. Danforth reserves the right to an
annual increase in consultant rates of up to 4%, effective January 1 of each year. Upon termination of this Agreement pursuant to Section 3, no compensation or benefits of any kind as described in this Section 2 shall be payable or
issuable to Danforth after the effective date of such termination. In addition, the Company will reimburse Danforth for reasonable out-of-pocket business expenses,
including but not limited to travel and parking, incurred by Danforth in performing the Services hereunder, upon submission by Danforth of supporting documentation reasonably acceptable to the Company. Any such accrued expenses in any given three
(3) month period that exceed one thousand dollars ($1,000) shall be submitted to the Company for its prior written approval. 

  
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 All Danforth invoices and billing matters should be addressed to: 

 

			
	 Company Accounts Payable Contact:
	  	Steven Nichtberger
		  	[****]
		  	[****]
		  	[****]
		  	[****]

 All Company payments and billing inquiries should be addressed to: 

 

			
	 Danforth Accounting:
	  	Betsy Sherr
		  	[****]
		  	[****]
		  	[****]
		  	[****]

  

	3.	 Term and Termination. The term of this Agreement will commence on the Effective Date and will continue
through the anniversary of such date in the next calendar year (the “Term”). This Agreement may be extended for an additional period by mutual written agreement. This Agreement may be terminated by either Party with or without cause upon
thirty (30) days prior written notice to the other Party. 

  

	4.	 Time Commitment. Danforth will devote such time to perform the Services under this Agreement as may
reasonably be required. 

  

	5.	 Place of Performance. Danforth will perform the Services at such locations upon which the Company and
Danforth may mutually agree. Danforth will not, without the prior written consent of the Company, perform any of the Services at any facility or in any manner that might give anyone other than the Company any rights to or allow for disclosure of any
Confidential Information (as defined below). 

  

	6.	 Compliance with Policies and Guidelines. Danforth will perform the Services in accordance with all rules
or policies adopted by the Company that the Company discloses in writing to Danforth. 

  

	7.	 Confidential Information. Danforth acknowledges and agrees that during the course of performing the
Services, the Company may furnish, disclose or make available to Danforth information, including, but not limited to, material, compilations, data, formulae, models, patent disclosures, procedures, processes, business plans, projections, protocols,
results of experimentation and testing, specifications, strategies and techniques, and all tangible and intangible embodiments thereof of any kind whatsoever (including, 

  
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but not limited to, any apparatus, biological or chemical materials, animals, cells, compositions, documents, drawings, machinery, patent applications, records and reports), which is owned or
controlled by the Company and is marked or designated as confidential at the time of disclosure or is of a type that is customarily considered to be confidential information (collectively the “Confidential Information”). Danforth
acknowledges that the Confidential Information or any part thereof is the exclusive property of the Company and shall not be disclosed to any third party without first obtaining the written consent of the Company. Danforth further agrees to ensure
that the Confidential Information, and part thereof, shall not be disclosed or issued to its affiliates, agents or employees, except on like terms of confidentiality memorialized in a written agreement with such affiliate, agent or employee as
applicable. The restrictions of this Section 7 shall not apply to information that is or becomes generally known in the trade other than by breach of the Agreement by the Consultant. The above provisions of confidentiality shall apply for a
period of five (5) years following the Term. 

  

	8.	 Intellectual Property. Danforth agrees that all ideas, inventions, discoveries, creations, manuscripts,
properties, innovations, improvements, know-how, inventions, designs, developments, apparatus, techniques, methods, and formulae that Danforth conceives, makes, develops or improves as a result of performing
the Services, whether or not reduced to practice and whether or not patentable, alone or in conjunction with any other party and whether or not at the request or upon the suggestion of the Company (all of the foregoing being hereinafter collectively
referred to as the “Inventions”), shall be the sole and exclusive property of the Company. Danforth hereby agrees in consideration of the Company’s agreement to engage Danforth and pay compensation for the Services rendered to the
Company and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged that Danforth shall not, without the prior written consent of the Company, directly or indirectly, consult for, or become an employee
of, any company which conducts business in the Field of Interest anywhere in the world. As used herein, the term “Field of Interest” shall mean the research, development, manufacture and/or sale of the products resulting from or that would
directly compete with the commercialization of the Company’s technology. The limitations on competition contained in this Section 8 shall continue during the time that Danforth performs any Services for the Company, and for a period of
three (3) months following the termination of any such Services that Danforth performs for the Company. If any part of this section should be determined by a court of competent jurisdiction to be unreasonable in duration, geographic area, or
scope, then this Section 8 is intended to and shall extend only for such period of time, in such area and with respect to such activity as is determined to be reasonable. Except as expressly provided herein, nothing in this Agreement shall
preclude Danforth from consulting for or being employed by any other person or entity. Danforth acknowledges that and agrees that the Company may require, as a condition to entering into this Agreement, that each representative of Danforth who will
be providing services to the Company under this Agreement execute an agreement with the Company governing invention assignment and confidentiality. 

  
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	9.	 Non Solicitation. All personnel representing Danforth are employees or contracted agents of Danforth. As
such, they are obligated to provide the Services to the Company and are obligated to Danforth under confidentiality, non-compete, and non-solicitation agreements.
Accordingly, they are not retainable as employees or contractors by the Company and the Company hereby agrees not to solicit, hire or retain their services for so long as they are employees or contracted agents of Danforth and for two (2) years
thereafter. Should the Company violate this restriction, it agrees to pay Danforth liquidated damages equal to thirty percent (30%) of the employee’s starting annual base salary and target annual bonus for each Danforth contracted agent hired
by the Company in violation of this Agreement, plus Danforth’s reasonable attorneys’ fees and costs incurred in enforcing this agreement should the Company fail or refuse to pay the liquidated damages amount in full within thirty
(30) days following its violation. 

  

	10.	 Placement Services. In the event that Danforth refers a potential employee to the Company and that
individual is hired by the Company as a full-time employee as a result of Danforth’s efforts within one (1) year of the date such applicant is submitted to the Company, and remains employed for at least sixty (60) days, Danforth shall
receive a payment equal to fifteen percent (15%) of the employee’s starting annual base salary and target annual bonus, such payment due within thirty (30) days of the employee’s start date. 

 

	11.	 No Implied Warranty. Except for any express warranties stated herein, the Services are provided on an
“as is” basis, and the Company disclaims any and all other warranties, conditions, or representations (express, implied, oral or written), relating to the Services or any part thereof. Further, in performing the Services Danforth is not
engaged to disclose illegal acts, including fraud or defalcations, which may have taken place. The foregoing notwithstanding, Danforth will promptly notify the Company if Danforth becomes aware of any such illegal acts during the performance of the
Services. Because the Services do not constitute an examination in accordance with standards established by the American Institute of Certified Public Accountants (the “AICPA”), Danforth is precluded from expressing an opinion as to
whether financial statements provided by the Company are in conformity with generally accepted accounting principles or any other standards or guidelines promulgated by the AICPA, or whether the underlying financial and other data provide a
reasonable basis for the statements. 

  

	12.	 Indemnification. Each Party hereto agrees to indemnify and hold the other Party hereto, its directors,
officers, agents and employees harmless against any claim related to performance under this Agreement and based upon circumstances alleged to be inconsistent with such representations and/or warranties contained in this Agreement. Further, the
Company shall indemnify and hold harmless Danforth and any of its employees and subcontractors against any claims, losses, damages or liabilities (or actions in respect thereof) that arise out of or are based on the Services performed hereunder,
except for any such claims, losses, damages or liabilities arising out of the gross negligence or willful misconduct of Danforth or any of its representatives. The Company will endeavor to add Consultant and any applicable representative to its
insurance policies as additional insureds. 

  
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	13.	 Independent Contractor. Danforth is not, nor shall Danforth be deemed to be at any time during the term
of this Agreement, an employee of the Company, and therefore Danforth shall not be entitled to any benefits provided by the Company to its employees, if applicable. Danforth’s status and relationship with the Company shall be that of an
independent contractor and consultant. Danforth shall not state or imply, directly or indirectly, that Danforth is empowered to bind the Company without the Company’s prior written consent. Nothing herein shall create, expressly or by
implication, a partnership, joint venture or other association between the parties. Danforth will be solely responsible for payment of all charges and taxes arising from his or her relationship to the Company as a consultant. 

 

	14.	 Records. Upon termination of Danforth’s relationship with the Company, Danforth shall deliver to
the Company any property or Confidential Information of the Company relating to the Services which may be in its possession including products, project plans, materials, memoranda, notes, records, reports, laboratory notebooks, or other documents or
photocopies and any such information stored using electronic medium. 

  

	15.	 Notices. Any notice under this Agreement shall be in writing (except in the case of verbal
communications, emails and teleconferences updating either Party as to the status of work hereunder) and shall be deemed delivered upon personal delivery, one day after being sent via a reputable nationwide overnight courier service or two days
after deposit in the mail or on the next business day following transmittal via facsimile. Notices under this Agreement shall be sent to the following representatives of the Parties: 

 

			
	 If to the Company:

		
	 Name:
	  	Steven Nichtberger
	 Title:
	  	Chief Executive Officer
	 Address:
	  	[****]
	 Phone:
	  	[****]
	 E-mail:
	  	[****]
	
	 If to Danforth:

		
	 Name:
	  	Gregg Beloff
	 Title:
	  	[****]
	 Address:
	  	[****]
		  	[****]
	 Phone:
	  	[****]
	 E-mail:
	  	[****]

  

	16.	 Assignment and Successors. This Agreement may not be assigned by a Party without the consent of the
other which consent shall not be unreasonably withheld, except that each Party may assign this Agreement and the rights, obligations and interests of such Party, in whole or in part, to any of its Affiliates, to any purchaser of all or substantially
all of its assets or to any successor corporation resulting from any merger or consolidation of such Party with or into such corporation. 

  
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	17.	 Force Majeure. Neither Party shall be liable for failure of or delay in performing obligations set forth
in this Agreement, and neither shall be deemed in breach of its obligations, if such failure or delay is due to natural disasters or any causes beyond the reasonable control of either Party. In the event of such force majeure, the Party affected
thereby shall use reasonable efforts to cure or overcome the same and resume performance of its obligations hereunder. 

  

	18.	 Headings. The Section headings are intended for convenience of reference only and are not intended to be
a part of or to affect the meaning or interpretation of this Agreement. 

  

	19.	 Integration; Severability. This Agreement is the sole agreement with respect to the subject matter
hereof and shall supersede all other agreements and understandings between the Parties with respect to the same. If any provision of this Agreement is or becomes invalid or is ruled invalid by any court of competent jurisdiction or is deemed
unenforceable, it is the intention of the Parties that the remainder of the Agreement shall not be affected. 

  

	20.	 Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the
Commonwealth of Massachusetts, excluding choice of law principles. The Parties agree that any action or proceeding arising out of or related in any way to this Agreement shall be brought solely in a Federal or State court of competent jurisdiction
sitting in the Commonwealth of Massachusetts. 

  

	21.	 Counterparts. This Agreement may be executed in counterparts, each of which will be deemed an original,
but all of which together will constitute one agreement. 

 If you are in agreement with the foregoing, please sign where indicated below,
whereupon this Agreement shall become effective as of the Effective Date. 
  

									
	DANFORTH ADVISORS, LLC	 		 	TYCHO THERAPEUTICS, INC.
					
	By:	 	 /s/ Gregg Beloff
	 		 	By:	 	 /s/ Steven Nichtberger

	Print Name: Gregg Beloff	 		 	Print Name: Steven Nichtberger
	Title: Managing Director	 		 	Title: Chief Executive Officer
			
	Date: 5/7/18	 		 	Date: 5/7/18

  
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 EXHIBIT A 

Description of Services and Schedule of Fees 

Danforth will perform mutually agreed to finance and accounting functions which are necessary to support the management and operations of the Company, certain
of which are set forth below. 
 Senior Advisor Services: 
  

	 	•	 	 Participate in longer-term strategic planning process 

 

	 	•	 	 Participate in financing activities, including additional capital raises and/or debt and equity restructurings

  

	 	•	 	 Oversee the finance and accounting functions, including the Danforth engagement team 

 

	 	•	 	 Board, Audit, Compensation, and Corporate Governance committee meeting preparation, support and attendance

 Director Services: 
 Start-up Services 
  

	 	•	 	 Review budget and long-range plan 

 

	 	•	 	 Oversee establishment of insurance, banking, benefits and payroll 

 

	 	•	 	 Development of initial cap table 

 

	 	•	 	 Investment policy 

On-going Services 
  

	 	•	 	 Manage the accounting and finance function 

 

	 	•	 	 Participate in strategic business planning 

 

	 	•	 	 Corporate and business development advisory work 

 

	 	•	 	 Financial modeling, planning and analysis 

 

	 	•	 	 Capitalization table management 

 

	 	•	 	 409(a) Valuation 

  

	 	•	 	 Manage and prepare for audit, as appropriate and necessary 

 

	 	•	 	 Maintain and audit corporate records (minute book, stock records, and option agreements) 

 

	 	•	 	 Board, Audit, Compensation, and Corporate Governance committee meeting preparation, support and attendance (as
requested by Company) 

  
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 Controller Services 

Start-up Services 
  

	 	•	 	 Create account/reporting structure in QB 

 

	 	•	 	 Set up GL/Chart of Accounts in QuickBooks 

 

	 	•	 	 Prepare annual budget 

  

	 	•	 	 Input of budget in QuickBooks for variance analysis 

 

	 	•	 	 Insurance and banking set-up 

 

	 	•	 	 Payroll and benefits set-up 

 

	 	•	 	 Establish purchasing and signing authority matrix 

Ongoing Maintenance 
  

	 	•	 	 Maintain the accounting system and general ledger 

 

	 	•	 	 Regular bookkeeping and accounting activities — monthly close, monthly reporting, and general financial
administration 

  

	 	•	 	 Establish and perform procedures for setting up new vendors (contracts,
W-9s) and paying monthly invoices; manage payables and cash disbursements 

  

	 	•	 	 Reconcile cash accounts, track cash usage and prepare cash flow projections 

 

	 	•	 	 Establish/maintain internal controls 

 

	 	•	 	 Manage insurance and banking 

 

	 	•	 	 Manage payroll and employee benefits 

 

	 	•	 	 Update and manage the Company’s cap table 

 

	 	•	 	 Financing, audit, budget, payroll/workers comp set up or other special project(s), as required and requested

  

	 	•	 	 Provide support for fundraising initiatives 

 

	 	•	 	 Assist with tax returns, as appropriate 

 

	 	•	 	 Prepare monthly financial statements and reporting packages for management and the Board 

 

	 	•	 	 Prepare Board materials 

 

			
	Fees:	  	
		
	 Senior Advisor: Daniel Geffken
	  	$325/hour
	 Director:
	  	Kathleen McGowan $275/hour
	 Controller:
	  	Debra Taylor $155/hour

  
 8EX-10.15

 Exhibit 10.15 

AMENDMENT NO. 1 TO CONSULTING AGREEMENT 

This Amendment No. 1 to Consulting Agreement (“Amendment”) is made as of May 7, 2019 (“Effective Date”), by and
between Cabaletta Bio, Inc. (formerly known as Tycho Therapeutics, Inc.), with a principal place of business being 2929 Arch Street, Suite 600, Philadelphia, PA 19104 (“Company”) and Danforth Advisors, LLC (“Consultant”), with a
principal place of business being [****] (“Danforth”). Capitalized terms used but not defined herein shall have the respective meanings set forth in the Consulting Agreement by and between Danforth Advisors and the Company dated as of
May 7, 2018 (“Agreement”). 
 WHEREAS, Consultant is engaged by the company under the terms and conditions of the
Consulting Agreement and the parties hereto desire to revise the terms of the Consulting Agreement on the terms and conditions set forth more fully herein; and 

WHEREAS, the Company and Consultant mutually desire to amend the term and scope of the Agreement 

NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained and for the other good and
valuable consideration, receipt of which is hereby acknowledge, the parties hereby agree as follows: 
  

	 	1.	 Section 3. Term and Termination is hereby modified to extend the term of the Agreement until
May 7, 2020. 

  

	 	2.	 Except as specifically provided for in this Amendment, the terms of the Agreement shall be unmodified and shall
remain in full force and effect. 

 Except as specifically provided for in this Amendment No. 1, the terms of the
Agreement shall be unmodified and shall remain in full force and effect. For avoidance of doubt this Agreement remained in effect the entire time between May 7, 2018 and the Effective Date of this Amendment No. 1. 

This Amendment may be executed in one or more counterparts, each of which shall be considered an original instrument, but all of which shall be
considered one and the same Amendment, and shall become binding when one or more counterparts have been signed by each of the parties and delivered to the other. 

IN WITNESS WHEREOF, this Amendment has been executed by the Company and Danforth Advisors, LLC to be effective as of the date first above
written. 
 ******** 

					
	DANFORTH ADVISORS, LLC	  		  	CABALETTA BIO, INC.
			
	/s/ Gregg Beloff	  		  	/s/ Anup Marda
	Name	  		  	Name
			
	Gregg Beloff	  		  	Anup Marda
	Print Name	  		  	 Print Name

			
	Managing Director	  		  	Chief Financial Officer
	Title	  		  	Title
			
	5/27/19	  		  	7/9/19
	Date	  		  	Date

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