Document:

First Supplemental Indenture

 Exhibit 4.1 
  
 Execution Copy 
  
 FIRST SUPPLEMENTAL INDENTURE, dated as of August 31, 2005 among (i) CENTRAL EUROPEAN DISTRIBUTION CORPORATION, a company incorporated under the laws of
Delaware (the “Company”), (ii) CAREY AGRI INTERNATIONAL-POLAND SP. Z O.O. (“Carey Agri”), ONUFRY S.A., MULTI-EX S.A., ASTOR SP. Z O.O., POLSKIE HURTOWNIE ALKOHOLI SP. Z O.O., MTC SP. Z O.O., PRZEDSIEBIORSTWO
DYSTRYBUCJI ALKOHOLI AGIS S.A., DAKO-GALANT PRZEDSIEBIORSTWO HANDLOWO PRODUKCYJNE SP. Z O.O., DAMIANEX S.A., PWW SP. Z O.O. AND MIRO SP. Z O.O., each a company organized under the laws of the Republic of Poland (the “Initial
Guarantors”), (iii) BOTAPOL HOLDING B.V., a company organized under the laws of the Netherlands, and BOLS SP. Z O.O., a company organized under the laws of the Republic of Poland (the “Additional Guarantors”), (iv) THE BANK
OF NEW YORK (the “Trustee”), and (v) ING BANK N.V., London Branch (the “Note Security Agent”). 
  
 WHEREAS, reference is made to that certain Indenture, dated as of July 25, 2005 (the “Indenture”), between the Company, the Initial
Guarantors, the Trustee and the Note Security Agent, with respect to the Company’s 8% Senior Secured Notes due 2012 (the “Notes”); 
  
 WHEREAS, pursuant to Section 4.22(a) of the Indenture, the Company and Carey Agri covenanted that on or prior to the tenth Business Day following the
completion of the Bols Acquisition, the Company and Carey Agri will cause Botapol and Bols to jointly and severally Guarantee the Notes pursuant to a supplemental indenture reasonably satisfactory to the Trustee; 
  
 WHEREAS, the Bols Acqusition was completed on August 17, 2005; 
  
 WHEREAS, the Additional Guarantors have agreed to fully and unconditionally
guarantee the Company’s obligations under the Indenture, which guarantee is provided in this First Supplemental Indenture, as permitted pursuant to Section 9.1(a) of the Indenture; 
  
 WHEREAS, in accordance with Section 9.1(a) of the Indenture, the Company, the Initial Guarantors, the Trustee and the Note
Security Agent may amend or supplement the Indenture without the consent of any Holder; 
  
 WHEREAS, the Company, the Initial Guarantors, the Trustee and the Note Security Agent desire to amend and supplement the Indenture in accordance with Section 9.1(a) of the Indenture; and 
  
 WHEREAS, the execution and delivery of this First Supplemental Indenture has
been duly authorized by the parties hereto, and all other acts necessary to make this First Supplemental Indenture a valid and binding supplement to the Indenture effectively amending the Indenture as set forth herein have been duly taken.

  
 NOW, THEREFORE, in consideration of the foregoing and for
other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company, the Initial Guarantors, the Additional Guarantors, the Trustee and the Note Security Agent mutually covenant and agree as follows:

  
 Section 1. Definitions. Capitalized terms used herein
without definition shall have the meanings ascribed to them in the Indenture. 

 Section 2. Amendment to the Indenture. The first paragraph of Section 10.1 of the Indenture is
amended and restated in its entirety to read as follows: 
  
 “Each of the Guarantors hereby fully, unconditionally and irrevocably Guarantees, as primary obligor and not merely as surety, on a senior basis to each Holder of a Note authenticated by the Trustee or the
Authenticating Agent and to the Trustee and the Note Security Agent and each of their successors and assigns the full and prompt performance of all of the Company’s obligations under this Indenture and the Notes including the payment of
principal of, and premium, if any, interest and Additional Amounts, if any, on the Notes and all other obligations of the Company to the Holders, the Trustee and the Note Security Agent hereunder and under the Notes. The obligations of the Company
under this Indenture and Notes shall be referred to herein as the “Obligations”.” 
  
 Section 3. Additional Guarantees. Each of the Additional Guarantors hereby fully, unconditionally and irrevocably Guarantees, as primary obligor
and not merely as surety, on a senior basis to each Holder of a Note authenticated by the Trustee or the Authenticating Agent and to the Trustee and the Note Security Agent and each of their successors and assigns the full and prompt performance of
all of the Company’s obligations under this Indenture and the Notes including the payment of principal of, and premium, if any, interest and Additional Amounts, if any, on the Notes and all other obligations of the Company to the Holders, the
Trustee and the Note Security Agent hereunder and under the Notes. Each Additional Guarantor further agrees and acknowledges that it shall be bound to the terms and conditions of Article X of the Indenture to the same extent as it would be so bound
were it to have been an Initial Guarantor on the Issue Date; provided, however, that the Guarantee, indemnity and other obligations of Botapol expressed to be assumed in this First Supplemental Indenture or elsewhere in the Indenture
shall be deemed not to be assumed by Botapol to the extent that the same would constitute unlawful financial assistance within the meaning of the Dutch Civil Code. 
  
 Section 4. No Personal Liability of Directors, Officers, Employees, Incorporators or Shareholders. No director,
officer, employee, incorporator or shareholder of the Company or any Initial Guarantor or Additional Guarantor, as such, shall have any liability for any obligations of the Company or any Guarantor under the Notes, this First Supplemental Indenture,
the Indenture or the Guarantees or for any claim based on, in respect of, or by reason of, such obligations or their creation; and that any and all such personal liability has been waived upon the execution of the Indenture or is hereby expressly
waived and released as a condition of, and as a consideration for, the execution of this First Supplemental Indenture and the issuance of the Additional Guarantees. 
  
 Section 5. Ratification and Effect. Except as hereby expressly amended and supplemented, the Indenture is in all
respects ratified and confirmed and all the terms, provisions and conditions thereof shall be and remain in full force and effect. Upon and after the execution of this First Supplemental Indenture, each reference in the Indenture to “this
Indenture”, “hereunder”, “hereof” or words of like import referring to the Indenture shall mean and be a reference to the Indenture as modified hereby. 
  

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 Section 6. Governing Law. This First Supplemental Indenture shall be governed by, and construed in
accordance with, the laws of the State of New York. 
  
 Section 7.
Submission to Jurisdiction; Appointment of Agent for Service. To the fullest extent permitted by applicable law, each of the Company and the Additional Guarantors irrevocably submits to the non-exclusive jurisdiction of and venue in any
federal or state court in the Borough of Manhattan in the City of New York, County and State of New York, United States of America, in any suit or proceeding based on or arising out of or under or in connection with this First Supplemental
Indenture, the Notes or the Additional Guarantees, and irrevocably agrees that all claims in respect of such suit or proceeding may be determined in any such court. Each of the Company and the Additional Guarantors, to the fullest extent permitted
by applicable law, irrevocably and fully waives the defense of an inconvenient forum to the maintenance of such suit or proceeding and hereby irrevocably designates and appoints the Corporation Service Company (the “Authorized
Agent”), as its authorized agent upon whom process may be served in any such suit or proceeding. The Company and the Additional Guarantors hereby irrevocably authorize and direct their Authorized Agent to accept such service. The Company
and the Additional Guarantors further agree that service of process upon their Authorized Agent and written notice of such service to the Company and the Additional Guarantors, as the case may be, as set forth above, shall be deemed in every respect
effective service of process upon the Company or the Additional Guarantors, as the case may be, in any such suit or proceeding. Nothing herein shall affect the right of any person to serve process in any other manner permitted by law. The Company
and the Additional Guarantors agree that a final action in any such suit or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other lawful manner. 
  
 The Company and the Additional Guarantors hereby irrevocably waive, to the
extent permitted by law, any immunity to jurisdiction to which it may otherwise be entitled (including, without limitation, immunity to pre-judgment attachment, post-judgment attachment and execution) in any legal suit, action or proceeding against
it arising out of or based on this Indenture, the Notes or the transactions contemplated hereby. 
  
 The provisions of this Section 7 are intended to be effective upon the execution of this First Supplemental Indenture without any further action by the
Company, the Additional Guarantors or the Trustee and the introduction of a true copy of this First Supplemental Indenture into evidence shall be conclusive and final evidence as to such matters. 
  
 Section 8. Counterpart Originals. All parties hereto may sign any
number of copies of this Indenture. Each signed copy or counterpart shall be an original, but all of them together shall represent one and the same agreement. 
  

Section 9. Headings, etc. The headings of the Sections of this First Supplemental Indenture have been inserted for convenience of reference
only, are not to be considered a part of this First Supplemental Indenture and shall in no way modify or restrict any of the terms or provisions hereof. 
  
 Section 10. Trustee. The Trustee makes no representations as to the validity or sufficiency of this First Supplemental Indenture. The recitals and
statements herein are deemed to be those of the Company and the Guarantors and not of the Trustee. 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed, as of the date
first written above. 
  

			
	 CENTRAL EUROPEAN DISTRIBUTION
 CORPORATION,

	as the Company
		
	By:	 	 /s/ William V. Carey

	Name:	 	Mr. William V. Carey
	Title:	 	Chief Executive Office and President
	
	 CAREY AGRI INTERNATIONAL-POLAND SP. Z
 O.O.,

	as a Guarantor
		
	By:	 	 /s/ William V. Carey

	Name:	 	Mr. William V. Carey
	Title:	 	President of the Management Board
	
	ONUFRY S.A.,
	as a Guarantor
		
	By:	 	 /s/ Evangelos Evangelou

	Name:	 	Mr. Evangelos Evangelou
	Title:	 	Vice President of the Management Board
	
	MULTI-EX S.A.,
	as a Guarantor
		
	By:	 	 /s/ Chris Biedermann

	Name:	 	Mr. Chris Biedermann
	Title:	 	Pursuant to a Power of Attorney
	
	ASTOR SP. Z O.O.,
	as a Guarantor
		
	By:	 	 /s/ William V. Carey

	Name:	 	Mr. William V. Carey
	Title:	 	President of the Management Board

  
 Signature Page to
First Supplemental Indenture 

			
	POLSKIE HURTOWNIE ALKOHOLI SP. Z O.O.,
	as a Guarantor
		
	By:	 	 /s/ Evangelos Evangelou

	Name:	 	Mr. Evangelos Evangelou
	Title:	 	Vice President of the Management Board
		
	By:	 	 /s/ Chris Biedermann

	Name:	 	Mr. Chris Biedermann
	Title:	 	Member of the Management Board
	
	MTC SP. Z O.O.,
	as a Guarantor
		
	By:	 	 /s/ William V. Carey

	Name:	 	Mr. William V. Carey
	Title:	 	Chief Executive Officer and President
	
	 PRZEDSIEBIORSTWO DYSTRYBUCJI
 ALKOHOLI AGIS
S.A.,

	as a Guarantor
		
	By:	 	 /s/ Evangelos Evangelou

	Name:	 	Mr. Evangelos Evangelou
	Title:	 	Member of the Management Board
	
	 DAKO-GALANT PRZEDSIEBIORSTWO
 HANDLOWO
PRODUKCYJNE SP. Z O.O.,

	as a Guarantor
		
	By:	 	 /s/ William V. Carey

	Name:	 	Mr. William V. Carey
	Title:	 	Vice President of the Management Board

  
 Signature Page to
First Supplemental Indenture 

			
	DAMIANEX S.A.,
	as a Guarantor
		
	By:	 	 /s/ Evangelos Evangelou

	Name:	 	Mr. Evangelos Evangelou
	Title:	 	Vice President of the Management Board
	
	PWW SP. Z O.O.
	as a Guarantor
		
	By:	 	 /s/ Evangelos Evangelou

	Name:	 	Mr. Evangelos Evangelou
	Title:	 	President of the Management Board
	
	MIRO SP. Z O.O.
	as a Guarantor
		
	By:	 	 /s/ Evangelos Evangelou

	Name:	 	Mr. Evangelos Evangelou
	Title:	 	Member of the Management Board
	
	BOTAPOL HOLDING B.V.,
	as a Guarantor
		
	By:	 	 /s/ William V. Carey

	Name:	 	Mr. William V. Carey
	Title:	 	Managing Director
		
	By:	 	 /s/ Chris Biedermann

	Name:	 	Mr. Chris Biedermann
	Title:	 	Managing Director

  
 Signature Page to
First Supplemental Indenture 

			
	BOLS SP. Z O.O.,
	as a Guarantor
		
	By:	 	 /s/ Maciej Dabrowiecki

	Name:	 	Mr. Maciej Dabrowiecki
	Title:	 	President of the Management Board
		
	By:	 	 /s/ Grzegorz Swiderski

	Name:	 	Mr. Grzegorz Swiderski
	Title:	 	Member of the Management Board
	
	THE BANK OF NEW YORK,
	as Trustee
		
	By:	 	 /s/ Charlotte Fricker

	Name:	 	Charlotte Fricker
	Title:	 	Assistant Vice President
	
	ING BANK N.V., London Branch
	as Note Security Agent
		
	By:	 	 /s/ Martijn Bruins

	Name:	 	Martijn Bruins
	Title:	 	Managing Director

  
 Signature Page to
First Supplemental IndentureEmployment Agreement

 Exhibit 10.1 
  
 EMPLOYMENT AGREEMENT 
  
 This EMPLOYMENT AGREEMENT (the “Agreement”) dated as of July 19, 2005 by and between Alexion Pharmaceuticals, Inc., a Delaware
corporation (the “Company”), and Vikas Sinha (the “Executive”). 
  
 WITNESSETH 
  
 WHEREAS, the Company desires to employ the Executive in an executive capacity and the Executive desires to be so employed, on the terms and conditions set forth below; 
  
 NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained, the parties
hereto agree as follows: 
  
 1. Employment. Duties and
Acceptance. 
  
 (a) The Company hereby employs the
Executive, for the Term (as hereinafter defined), to render full-time services to the Company as Senior Vice President and Chief Financial Officer, and to perform such duties commensurate with such office as the Executive shall reasonably be
directed by the Board of Directors (the “Board of Directors”) of the Company or its designees to perform, which duties shall be consistent with the provisions of the Bylaws in effect on the date hereof that relate to the duties of
the Chief Financial Officer. The Executive will report directly to the President or Chief Executive Officer. 
  
 (b) The Executive hereby accepts such employment and agrees to render the services described above. 
  
 (c) The principal place of employment of the Executive hereunder shall at
all times during the Term be in the greater New Haven, Connecticut area, or other locations acceptable to the Executive, in the Executive’s sole discretion. 
  
 (d) With the prior approval of the Chief Executive Officer of the Company, the Executive may serve on boards of directors
of non-profit institutions and other companies that are not competitive with the Company, and participate in professional, community and/or philanthropic activities (collectively, “Permitted Activities”); provided,
however, that such Permitted Activities do not interfere with the Executive’s duties to the Company. 
  
 2. Term of Employment. 
  
 The term of the Executive’s employment under this Agreement (the “Term”) commences as of the Executive’s yet to be determined
employment start date between August 1 and September 1, 2005 (the “Effective Date”) and shall end on the third anniversary thereof, unless sooner terminated pursuant to Section 6, 7 or 8 of this Agreement. Notwithstanding the
foregoing, unless notice is given by the Executive or the Company at least six months prior to 
  

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 the expiration of the Term of this Agreement (or at least six months prior to the expiration of any extension hereof),
the Term of the Agreement shall be automatically extended by one year from the date it would otherwise end (whether upon expiration of the original Term or any extension(s) thereof), unless sooner terminated pursuant to Section 6, 7 or 8 hereof.

  
 3. Compensation and Benefits. 
  
 The Offer Letter signed by the Company and the Executive dated July 19, 2005 describes the
agreed compensation package. 
  
 (a) As compensation for services
to be rendered pursuant to this Agreement, the Company agrees to pay the Executive an annual base salary of $280,000 for the first year of the Term and for each subsequent year of the Term an amount to be determined by the Company (the “Base
Salary”), payable in accordance with its regular payroll practices. The Executive’s Base Salary hereunder shall be reviewed as of July 31, 2006 and at least annually thereafter during the Term of the Agreement for increase in the
discretion of the Board of Directors or the Compensation Committee of the Board of Directors, after consultation with the Company’s Chief Executive Officer. Base Salary, as adjusted, shall be considered the new Base Salary for all purposes of
this Agreement. 
  
 (b) The Company agrees that the Executive
shall be eligible for an annual performance bonus from the Company with respect to each fiscal year of the Company that ends during the Term, pursuant to the Company’s management incentive bonus program in effect from time to time. The amount
of any such bonus shall be determined by the Board of Directors or the Compensation Committee of the Board of Directors in its discretion, consistent with the Company’s performance, the Executive’s contribution to the Company’s
performance and the provisions of any applicable incentive bonus program. 
  
 (c) The Company agrees to grant to the Executive during the Term, at the time of its usual annual, or semi-annual, grant to employees for the applicable year, such options to purchase shares of the Company’s
common stock or other equity awards as the Board of Directors or the Compensation Committee of the Board of Directors shall determine. In the event of the consummation of a Change in Control (as defined in Section 14) of the Company, (i) all
time-vesting stock options and any other time-vesting equity awards previously granted to the Executive shall immediately become exercisable and/or vested, as the case may be, and remain exercisable and/or vested through their original terms with
full rights as if the Executive’s employment had not terminated, and (ii) all performance-based stock options and any other performance-based equity awards previously granted to the Executive will become exercisable and/or vested as determined
in good faith by the Board of Directors based on the percentage goals and objectives achieved by the Executive and the Company. 
  
 (d) The Company shall pay or reimburse the Executive for all reasonable expenses actually incurred or paid by the Executive during the Term in the
performance of services under this Agreement, upon presentation of expense statements or vouchers or such other supporting information as it reasonably may require. 
  
 (e) During the Term, the Executive shall be eligible to participate in all 
  

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 qualified and non-qualified savings and retirement plans, and all other compensation and benefit plans and programs,
including welfare and fringe benefit programs, that are generally available to other senior executives of the Company. 
  
 (f) During the Term, the Executive shall be eligible for paid vacation of four weeks per calendar year taken in accordance with the vacation policy of
the Company. 
  
 4. Confidentiality. 
  
 The Executive agrees that the “Proprietary Information and Inventions
Agreement” annexed hereto as Exhibit A shall be deemed incorporated in and made a part of this Employment Agreement. Notwithstanding any other provision of this Agreement, the Executive shall continue to be bound by the terms of such
Proprietary Information and Inventions Agreement for a period of five years after the termination of this Agreement for any reason. The Executive and the Company agree that following termination of this Agreement for any reason, confidentiality
provisions of the Proprietary Information and Inventions Agreement shall be applicable only to material, non-public proprietary information of the Company. 
  
 5. Non-Competition, Non-Solicitation and Non-Disparagement. 
  
 (a) During the Term, the Executive shall not (1) provide any services, directly or indirectly, to any other business or
commercial entity or (2) participate in the formation of any business or commercial entity; provided, however, that nothing contained in this Section 5(a) shall be deemed to prohibit the Executive from acquiring, solely as an
investment, shares of capital stock (or other interests) of any corporation (or other entity) not exceeding 2% of such corporation’s (or other entity’s) then outstanding shares of capital stock and provided, further, that
nothing contained herein shall be deemed to limit the Executive’s Permitted Activities pursuant to Section 1(d). 
  
 (b) If the Executive is terminated by the Company for Cause (as defined in Section 6(c)) or if the Executive terminates this Agreement other than in
accordance with Section 7 following a Constructive Termination or for Good Reason under Section 8 hereof, then for a period of one year following the date of termination or, if the Executive receives Severance Payments in accordance with Section
9(c), or payments under Section 9(d), then for the period such Severance Payments or payments are received, the Executive shall not (1) provide any services, directly or indirectly, to any other business or commercial entity in the Company’s
Field of Interest (as defined in Section 14), (2) participate in the formation of any business or commercial entity engaged primarily in the Company’s Field of Interest, or (3) directly or indirectly employ, or seek to employ or secure the
services in any capacity of, any person employed at that time by the Company or any of its Affiliates, or otherwise encourage or entice any such person to leave such employment; provided, however, that nothing contained in this Section
5(b) shall be deemed to prohibit the Executive from acquiring, solely as an investment, shares of capital stock (or other interests) of any corporation (or other entity) in the Company’s Field of Interest not exceeding 2% of such
corporation’s (or other entity’s) then outstanding shares of capital stock and provided, further, that nothing contained herein shall be deemed to limit Executive’s Permitted Activities pursuant to Section 1(d). This
Section 5(b) shall be subject to written waivers that may be obtained by the Executive from the Company. 
  

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 (c) At no time during the Term of this Agreement or thereafter will Executive knowingly make any written
or oral statement that disparages the Company or its Affiliates in communications with any customer, client or the public. 
  
 (d) If the Executive commits a breach, or threatens to commit a breach, of any of the provisions of this Section 5 or Exhibit A, the Company shall
have the right and remedy to have the provisions of this Agreement specifically enforced by any court having equity jurisdiction, it being acknowledged and agreed that any such breach or threatened breach will cause irreparable injury to the Company
and that money damages will not provide an adequate remedy to the Company. 
  
 (e) If any of the covenants contained in this Section 5 or Appendix A, or any part thereof, is hereafter construed to be invalid or unenforceable, the same shall not affect the remainder of the covenant or
covenants, which shall be given full effect without regard to the invalid portions. 
  
 (f) If any of the covenants contained in this Section 5 or Appendix A, or any part thereof, is held to be unenforceable because of the duration of such provision or the area covered thereby, the parties agree
that the court making such determination shall have the power to reduce the duration and/or area of such provision and, in its reduced form, such provision shall then be enforceable. 
  
 (g) The parties hereto intend to and hereby confer jurisdiction to enforce the covenants contained in this Section 5 and
Appendix A upon the courts of any state within the geographical scope of such covenants. In the event that the courts of any one or more of such states shall hold any such covenant wholly unenforceable by reason of the breadth of such scope
or otherwise, it is the intention of the parties hereto that such determination not bar or in any way affect the Company’s right to the relief provided above in the courts of any other states within the geographical scope of such other
covenants, as to breaches of such covenants in such other respective jurisdictions, the above covenants as they relate to each state being, for this purpose, severable into diverse and independent covenants. 
  
 6. Termination by the Company. 
  
 The Company may terminate the Executive as follows during the Term of this
Agreement, if any one or more of the following shall occur: 
  
 (a) The Executive shall die during the Term; provided, however, that the Executive’s legal representatives shall be entitled to receive the (1) Executive’s Base Salary through the date which is 90 days after the
Executive’s date of death and (2) a pro-rata annual performance bonus with respect to the fiscal year of the Company during which death occurs. Upon the Executive’s death, stock options and other equity awards previously granted to the
Executive shall become exercisable and/or vested, as the case may be, in accordance with the terms of the Company’s applicable stock option or incentive plan and any individual award agreements under which such stock options or equity awards
were granted.. 
  

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 (b) The Executive shall become physically or mentally disabled so that the Executive is unable
substantially to perform his services hereunder for (1) a period of 120 consecutive days, or (2) for shorter periods aggregating 180 days during any twelve-month period. Notwithstanding such disability the Company shall continue to pay the Executive
his Base Salary through the date of such termination. In addition, the Executive shall be entitled to a pro-rata annual performance bonus with respect to the fiscal year of the Company during which such termination occurs. Upon such a disability,
stock options and other equity awards previously granted to the Executive shall become exercisable and/or vested, as the case may be, in accordance with the terms of the Company’s applicable stock option or incentive plan and any individual
award agreements under which such stock options or equity awards were granted. 
  
 (c) By the Company for Cause. If the Executive acts, or fails to act, in a manner that provides Cause for termination, the Company may immediately terminate the Executive’s employment upon notice by the
Company to the Executive. For purposes of this Agreement, the term “Cause” means (1) the Executive’s indictment for, or conviction of, any crime or serious offense involving money or other property which constitutes a felony in
the jurisdiction involved, (2) the Executive’s willful and continual neglect or failure to discharge his duties (including fiduciary duties), responsibilities and obligations with respect to the Company hereunder; provided such neglect or
failure remains uncured for a period of 30 days after written notice describing the same is given to the Executive; provided that isolated and insubstantial neglect or failures shall not constitute Cause hereunder, (3) the Executive’s violation
of any of the non-competition provisions of Section 5 hereof or the Executive’s breach of any confidentiality provisions contained in Exhibit A hereto, or (4) any act of fraud or embezzlement by the Executive involving the Company or any
of its Affiliates. All determinations of Cause for termination pursuant to this Section 6 shall be determined by the Board of Directors. 
  
 7. Termination by the Executive. 
  
 The Executive may terminate this Agreement on written notice to the Company in the event of a material breach of the terms of this Agreement by the
Company and such breach continues uncured for 30 days after written notice of such breach is first given; provided, however, it shall constitute the termination of this Agreement if such breach is for the payment of money and continues
uncured for ten days after written notice of such breach is given. Such termination by the Executive is deemed to follow a “Constructive Termination” by the Company. 
  
 8. Termination Following a Change in Control. 
  
 In addition to the above, during the period commencing on the six month anniversary of a Change in Control (as defined in
Section 14) of the Company and ending on the two year anniversary of such Change in Control, the Executive may terminate this Agreement upon expiration of 90 days’ prior written notice if “Good Reason” exists for the
Executive’s termination. For this purpose, termination of the Executive for “Good Reason” shall mean a termination of the Executive of his employment hereunder following the occurrence, 
  

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 without his prior written consent, of any of the following events, unless the Company fully cures all grounds for such
termination within 30 days after the Executive’s notice: 
  
 (a) any material adverse change in the Executive’s authority, duties, titles or offices (including reporting responsibility), or any significant increase in the Executive’s business travel obligations, from those existing
immediately prior to the Change in Control; 
  
 (b) any failure
by the Company to continue in effect any compensation plan in which the Executive participated immediately prior to such Change in Control and which is material to the Executive’s total compensation, including but not limited to the
Company’s stock option, bonus and other plans or any substitute plans adopted prior to the Change in Control, unless an equitable arrangement (embodied in an ongoing substitute or alternative plan) has been made with respect to such plan, or
any failure by the Company to continue the Executive’s participation therein (or in such substitute or alternative plan) on a basis no less favorable to the Executive, both in terms of the amount of benefits provided and the level of the
Executive’s participation relative to other participants, as existed immediately prior to such Change in Control; 
  
 (c) any failure by the Company to continue to provide the Executive with benefits substantially similar to those enjoyed by the Executive under any of
the Company’s retirement, life insurance, medical, health and accident, or disability plans, programs or arrangements in which the Executive was participating immediately prior to such Change in Control, the taking of any action by the Company
which would directly or indirectly materially reduce any of such benefits or deprive the Executive of any perquisite enjoyed by the Executive at the time of such Change in Control, or the failure by the Company to maintain a vacation policy with
respect to the Executive that is at least as favorable as the vacation policy (whether formal or informal) in place with respect to the Executive immediately prior to such Change in Control; or 
  
 (d) the failure of the Company to obtain the assumption in writing of its
obligation to perform this Agreement by any successor to all or substantially all of the assets of the Company upon a merger, consolidation, sale or similar transaction. 
  
 9. Severance and Benefit Continuation. 
  
 (a) Termination for Cause. If the Company terminates this Agreement for Cause pursuant to Section 6(c)
hereof, or if the Executive terminates this Agreement other than pursuant to Section 7 following a Constructive Termination or for Good Reason under Section 8 hereof, no severance or benefit continuation provisions shall apply, provided
however, that the Executive shall have the same opportunity to continue group health benefits at the Executive’s expense in accordance with the Consolidated Omnibus Budget Reconciliation Act of 1985 (“COBRA”) as is
available generally to other employees terminating employment with the Company. 
  
 (b) Termination for Death or Disability. In the event of termination of this Agreement pursuant to Section 6(a) or 6(b) by reason of the death or disability of the Executive, in addition to the Base
Salary payments and pro-rata annual performance bonus provided for in paragraph (a) or (b) of Section 6, as applicable, the Company shall continue to provide all benefits subject to COBRA at its expense with respect to the Executive and his
dependents for the maximum period provided by COBRA. 
  

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 (c) Involuntary Termination Other Than for Cause, Voluntary Termination for Material Breach, or
Non-renewal by the Company. If (1) the Company terminates this Agreement other than pursuant to Section 6 hereof, (2) the Executive terminates this Agreement in accordance with Section 7 following a Constructive Termination, or (3) at the
end of the Term of this Agreement the Executive shall cease to be employed by the Company in the capacity of Chief Financial Officer by reason of the Company’s decision not to continue to employ the Executive as Chief Financial Officer at least
on terms substantially similar to those set forth herein, and in each case the termination of employment does not occur within two years following the consummation of a Change in Control of the Company, then: 
  
 (i) the Company shall pay the Executive in accordance with its normal
payroll practice an amount equal to the sum of (A) the Executive’s Base Salary at the time of his termination of employment and (B) the average bonus received by the Executive for the two years preceding the year in which his termination of
employment occurs (the “Severance Payments”) for a period of one year immediately following the date of termination (the “Severance Period”); 
  
 (ii) all Company employee benefit plans and programs (including, but not limited to, the plans and programs set forth in
Section 3(e)), other than participation in any Company tax-qualified retirement plan, applicable to the Executive shall be continued for the Severance Period (or, if such benefits are not available, or cannot be provided due to applicable law, the
Company shall pay the Executive a lump sum cash amount equal to the after-tax economic equivalent thereof, provided that with respect to any benefit to be provided on an insured basis, such lump sum cash value shall be the present value of the
premiums expected to be paid for such coverage, and with respect to other benefits, such value shall be the present value of the expected cost to the Company of providing such benefits). In the case of all benefits subject to COBRA, the Company
shall continue to provide such benefits at its expense with respect to the Executive and his dependents for the maximum period provided by COBRA; and 
  
 (iii) (A) all time-vesting stock options and any other time-vesting equity awards previously granted to the Executive shall immediately become
exercisable and/or vested, as the case may be, and remain exercisable and/or vested through their original terms with full rights as if the Executive’s employment had not terminated, and (B) all performance-based stock options and any other
performance-based equity awards previously granted to the Executive will become exercisable and/or vested as determined in good faith by the Board of Directors based on the percentage goals and objectives achieved by the Executive and the Company.

  
 (d) Involuntary Termination Other Than for Cause,
Voluntary Termination for Material Breach or Good Reason, or Nonrenewal by the Company, Upon a Change in Control. If (1) the Company terminates this Agreement other than pursuant to Section 6 hereof, (2) the Executive terminates this
Agreement in accordance with Section 7 following a Constructive Termination or for Good Reason under Section 8 hereof, or (3) at the end of the Term of this Agreement, the Executive shall cease to be employed by the Company in the capacity of Chief

  

 7 

 Financial Officer by reason of the Company’s decision not to continue to employ the Executive as Chief Financial
Officer at least on terms substantially similar to those set forth herein, and in each case the termination of employment occurs within two years of the consummation of a Change in Control of the Company, then: 
  
 (i) the Company shall pay the Executive a cash lump sum immediately upon
such termination of employment equal to 1.5 times the sum of (A) the Executive’s Base Salary at the time of his termination of employment and (B) the average bonus received by the Executive for the two years preceding the year in which his
termination of employment occurs; 
  
 (ii) all Company employee
benefit plans and programs (including, but not limited to, the plans and programs set forth in Sections 3(e), other than participation in any Company tax-qualified retirement plan, applicable to the Executive shall be continued for one-and-a-half
years from the date of such termination of employment (or, if such benefits are not available, or cannot be provided due to applicable law, the Company shall pay the Executive a lump sum cash amount equal to the after-tax economic equivalent
thereof, provided that with respect to any benefit to be provided on an insured basis, such lump sum cash value shall be the present value of the premiums expected to be paid for such coverage, and with respect to other benefits, such value shall be
the present value of the expected cost to the Company of providing such benefits). In the case of all benefits subject to COBRA, the Company shall continue to provide such benefits at its expense with respect to the Executive and his dependents for
the maximum period provided by COBRA; and 
  
 (iii) (A) all
time-vesting stock options and any other time-vesting equity awards previously granted to the Executive shall immediately become exercisable and/or vested, as the case may be, and remain exercisable and/or vested through their original terms with
full rights as if the Executive’s employment had not terminated, and (B) all performance-based stock options and any other performance-based equity awards previously granted to the Executive will become exercisable and/or vested as determined
in good faith by the Board of Directors based on the percentage goals and objectives achieved by the Executive and the Company; 
  
 (e) The payments provided in Section 9(c) and 9(d) are intended as enhanced severance for a termination by the Company without Cause, or a termination by
the Executive in the circumstances provided. As a condition of receiving such payments, the Executive shall first execute and deliver a general release of all claims against the Company, its Affiliates, agents and employees (other than any claims or
rights pursuant to this Agreement or pursuant to equity or employee benefit plans), in a form and substance reasonably satisfactory to the Company. 
  
 10. Cooperation. 
  
 Following his termination of employment, the Executive agrees to cooperate with, and assist, the Company to ensure a smooth transition in management and,
if requested by the Company, will make himself available to consult during regular business hours at mutually agreed upon times for up to a three month period thereafter. At any time following his termination of 
  

 8 

 employment, the Executive will provide such information as the Company may reasonably request with respect to any
Company-related transaction or other matter in which the Executive was involved in any way while employed by the Company. The Executive further agrees, during the Term of this Agreement and thereafter, to assist and cooperate with the Company in
connection with the defense or prosecution of any claim that may be made against, or by, the Company or its Affiliates, in connection with any dispute or claim of any kind involving the Company or its Affiliates, including providing testimony in any
proceeding before any arbitral, administrative, judicial, legislative or other body or agency. The Executive shall be entitled to reimbursement for all properly documented expenses incurred in connection with rendering services under this Section,
including, but not limited to, reimbursement for all reasonable travel, lodging, meal expenses and legal fees, and, in addition, in the event the Executive is not receiving Severance Payments under Section 9(c) or payments under Section 9(d), the
Executive shall be entitled to a per diem amount for his services equal to his then most recent annualized Base Salary under this Agreement, divided by 240 (business days). 
  
 11. Indemnification. 
  
 The Company shall indemnify the Executive, to the maximum extent permitted by applicable law, against all costs, charges and expenses incurred or
sustained by the Executive in connection with any action, suit or proceeding to which the Executive may be made a party by reason of being an officer, director or employee of the Company or of any subsidiary or Affiliate of the Company, or
consultant pursuant to Section 10 above. The Company shall provide, at its expense, Directors and Officers insurance for the Executive in amounts reasonably satisfactory to the Executive, to the extent such insurance is available at reasonable
rates, which determination shall be made by the Board of Directors. 
  
 12. Excise Tax. 
  
 If any payments made in
respect of this Agreement, or otherwise in respect of the Executive’s employment or termination of employment with the Company, become subject to the excise tax described in Section 4999 of the Internal Revenue Code of 1986 (or any successor to
such section), then the Executive shall have an option of receiving a reduced payment or receiving a full payment without a gross-up from the Company only if the full payment without a gross-up results in a greater amount retained by the Executive
after payment by the Executive of excise taxes. The determination of whether any payment is subject to an excise tax shall be made by an independent auditor selected by the Company. The auditor shall be a nationally recognized public accounting firm
that has not, during the two years preceding the date of its selection, acted in any way on behalf of the Company or any of its Affiliates.. 
  
 13. No Mitigation. 
  
 The Executive shall not be required to mitigate the amount of any payment provided for hereunder by seeking other employment or otherwise, nor shall the
amount of any payment provided for hereunder be reduced by any compensation earned by the Executive as the result of employment by another employer after the date of termination of employment by the Company. 
  

 9 

 14. Definitions. 
  
 As used herein, the following terms have the following meaning: 
  
 (a) “Affiliate” means and includes any person, corporation
or other entity controlling, controlled by or under common control with the corporation in question. 
  
 (b) “Change in Control” means the occurrence of any of the following events: 
  
 (i) Any Person, other than the Company, its affiliates (as defined in Rule
12b-2 under the Exchange Act) or any Company employee benefit plan (including any trustee of such plan acting as trustee), is or becomes the Beneficial Owner, directly or indirectly, of securities of the Company representing more than 40% of the
combined voting power of the then outstanding securities entitled to vote generally in the election of directors (“Voting Securities”) of the Company, or 
  
 (ii) Individuals who constitute the Board of Directors of the Company (the “Incumbent Directors”) as of
the beginning of any twenty-four month period (not including any period prior to the date of this Agreement), cease for any reason to constitute at least a majority of the directors. Notwithstanding the foregoing, any individual becoming a director
subsequent to the beginning of such period, whose election or nomination for election by the Company’s stockholders was approved by a vote of at least two-thirds of the directors then comprising the Incumbent Directors, shall be considered an
Incumbent Director; or 
  
 (iii) Consummation by the Company of a
recapitalization, reorganization, merger, consolidation or other similar transaction (a “Business Combination”), with respect to which all or substantially all of the individuals and entities who were the beneficial owners of the
Voting Securities immediately prior to such Business Combination (the “Incumbent Shareholders”) do not, following consummation of all transactions intended to constitute part of such Business Combination, beneficially own, directly
or indirectly, more than 50% of the Voting Securities of the corporation, business trust or other entity resulting from or being the surviving entity in such Business Combination (the “Surviving Entity”), in substantially the same
proportion as their ownership of such Voting Securities immediately prior to such Business Combination; or 
  
 (iv) Consummation of a complete liquidation or dissolution of the Company, or the sale or other disposition of all or substantially all of the assets of
the Company, other than to a corporation, business trust or other entity with respect to which, following consummation of all transactions intended to constitute part of such sale or disposition, more than 50% of the combined Voting Securities is
then owned beneficially, directly or indirectly, by the Incumbent Shareholders in substantially the same proportion as their ownership of the Voting Securities immediately prior to such sale or disposition. 
  
 For purposes of this definition, the following terms shall have the meanings
set forth below: 
  
 (A) “Beneficial
Owner” shall have the meaning set forth in Rule 13d-3 under the Exchange Act; 
  

 10 

 (B) “Exchange Act” shall mean the Securities Exchange Act of 1934, as
amended; and 
  
 (C) “Person”
shall have the meaning as used in Sections 13(d) and 14(d) of the Exchange Act. 
  
 (c) “Company’s Field of Interest” means (i) the primary businesses of the Company as described in the Company’s then most-recent filings with the Securities and Exchange Commission during
the Executive’s employment hereunder and as determined from time to time by the Board of Directors during the Term hereof and (ii) businesses involving products or product candidates directly or indirectly competitive to the Company’s
products or product candidates that are, or with respect to which the Company has completed, on the date of the Executive’s termination clinical trials or animal testing. 
  
 15. Representations by Executive. 
  
 The Executive represents and warrants that he has full right, power and authority to execute the terms of this Agreement;
this Agreement has been duly executed by the Executive and such execution and the performance of this Agreement by the Executive does not result in any conflict, breach or violation of or default under any other agreement or any judgment, order or
decree to which the Executive is a party or by which he is bound. The Executive acknowledges and agrees that any material breach of the representations set forth in this Section will constitute Cause under Section 6. 
  
 16. Arbitration. 
  
 Any controversy or claim arising out of or relating to this Agreement or
the breach thereof (including, without limitation, disputes under Title VII, the ADEA, the ADA and other state and federal discrimination or employment laws) shall be settled by arbitration in Connecticut, in accordance with the employment dispute
rules then existing of the American Arbitration Association, and judgment upon the award rendered may be entered in any court having jurisdiction thereof. The parties shall be free to pursue any remedy before the arbitrator that they shall be
otherwise permitted to pursue in a court of competent jurisdiction. The award of the arbitrator shall be final and binding. The costs of the American Arbitration Association and the arbitrator will be borne equally by the Company and the Executive,
subject to the provisions of Section 17. 
  
 17. Legal
Costs. 
  
 If the Executive institutes any legal action to
enforce his rights under, or to recover damages for breach of, this Agreement, and the Executive prevails, he shall be entitled to recover from the Company any actual expenses for attorney’s fees and disbursements incurred by 
  

 11 

 the Executive. If any payment made to or in respect of the Executive pursuant to this Section 17 becomes subject to any
tax, the Company shall make a special payment to the Executive sufficient, on an after-tax basis (taking into account federal, state and local taxes and related interest and penalties), to put the Executive in the same position as would have been
the case had no such taxes been applicable to any payments or benefits provided in this Section. 
  
 18. Notices. 
  
 All notices, requests, consents and other communications required or permitted to be given hereunder shall be in writing and shall be deemed to have been
duly given if sent by private overnight mail service (delivery confirmed by such service), registered or certified mail (return receipt requested and received), telecopy (confirmed receipt by return fax from the receiving party) or delivered
personally, as follows (or to such other address as either party shall designate by notice in writing to the other in accordance herewith): 
  
 If to the Company: 
  
 Thomas I.H. Dubin, Esq. 
 Vice President and
General Counsel 
 Alexion Pharmaceuticals, Inc. 
 352 Knotter Drive 
 Cheshire, Connecticut 06410 
 Telephone:    (203) 272-2596 
 Fax:               (203) 271-8199 
  
 If to the Executive: 
  
 Vikas Sinha 
 Alexion Pharmaceuticals, Inc.

 352 Knotter Drive 
 Cheshire,
Connecticut 06410 
 Telephone:    (203) 272-2596 
 Fax:               (203) 271-8199 
  
 19. General. 
  
 (a) This Agreement shall be governed by and construed and enforced in
accordance with the laws of the State of Connecticut applicable to agreements made and to be performed entirely in Connecticut by Connecticut residents. 
  
 (b) This Agreement sets forth the entire agreement and understanding of the parties relating to the subject matter hereof, and supersedes all prior
agreements, arrangements and understandings, written or oral, relating to the subject matter hereof. No representation, promise or inducement has been made by either party that is not embodied in this Agreement, and neither party shall be bound by
or liable for any alleged representation, promise or inducement not so set forth. 
  

 12 

 (c) This Agreement may be amended, modified, superseded, canceled, renewed or extended, and the terms or
covenants hereof may be waived, only by a written instrument executed by the parties hereto, or in the case of a waiver, by the party waiving compliance. The failure of a party at any time or times to require performance of any provision hereof
shall in no manner affect the right at a later time to enforce the same. No waiver by a party of the breach of any term or covenant contained in this Agreement, whether by conduct or otherwise, or any one or more or continuing waivers of any such
breach, shall constitute a waiver of the breach of any other term or covenant contained in this Agreement 
  
 (d) This Agreement shall be binding upon the legal representatives, heirs, distributees, successors and assigns of the parties hereto. The Company may
not assign its rights and obligation under this Agreement without the prior written consent of the Executive, except to a successor of substantially all the Company’s business which expressly assumes the Company’s obligations hereunder in
writing. In the event of a sale of all or substantially all of the assets of the Company, the Company shall use its best efforts to cause the purchaser to expressly assume this Agreement. The Executive may not assign, transfer, alienate or encumber
any rights or obligations under this Agreement, except by will or operation of law, provided that the Executive may designate beneficiaries to receive any payments permitted under the terms of the Company’s benefit plans. 
  
 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date
first above written. 
  

			
	ALEXION PHARMACEUTICALS, INC.
		
	 By:
	 	 /s/ David Keiser

	 	 	David Keiser
		
	 	 	 /s/ Vikas Sinha

	 	 	VIKAS SINHA

  

 13

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