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Exhibit 10.7    
    

LOAN AND SECURITY AGREEMENT  

        THIS LOAN AND SECURITY AGREEMENT (this "Agreement") dated as of
June 23, 2006 (the "Effective Date") between SILICON VALLEY BANK, a California corporation and with a loan production office located at One
Newton Executive Park, Suite 200, 2221 Washington Street, Newton, Massachusetts 02462, ("Bank"), and SIRTRIS
PHARMACEUTICALS, INC., a Delaware corporation ("Borrower"), provides the terms on which Bank shall lend to Borrower and
Borrower shall repay Bank. The parties agree as follows: 

        1    ACCOUNTING AND OTHER TERMS    

        Accounting
terms not defined in this Agreement shall be construed following GAAP. Calculations and determinations must be made following GAAP. Capitalized terms not otherwise defined in
this Agreement shall have the meanings set forth in Section 13. All other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the Code to the
extent such terms are defined therein. 

        2    LOAN AND TERMS OF PAYMENT    

        2.1    Promise to Pay.    Borrower hereby unconditionally promises to
pay Bank the outstanding principal amount of all Credit Extensions and accrued and unpaid interest thereon as and when due in accordance with this Agreement. 

        2.1.1    Equipment Advances.    

        (a)    Availability.    Subject to the terms and conditions of this Agreement, during the Draw Period, Bank shall make
advances (each, an "Equipment Advance" and, collectively, "Equipment Advances") not
exceeding the Equipment Line. Equipment Advances may only be used to finance Eligible Equipment purchased within ninety (90) days (determined based upon the applicable invoice date of such
Eligible Equipment) before the date of Borrower's request for each Equipment Advance, and no Equipment Advance may exceed 100% of the total invoice for Eligible Equipment, excluding taxes, warranty
charges, freight expenses and installation expenses relating to such Eligible Equipment. Notwithstanding the foregoing, the initial Equipment Advance (the "Initial Equipment Advance") hereunder may be
used to reimburse Borrower for Eligible Equipment purchased on or after January 1, 2005, provided that the Initial Equipment Advance is requested on or before ten (10) days after the
Effective Date and provided further that the Initial Equipment Advance shall not be for greater than One Million Dollars ($1,000,000.00). Unless otherwise agreed to by Bank, not more than 25% of the
proceeds of the Equipment Line shall be used to finance Other Equipment. Each Equipment Advance, other than the final Equipment Advance, must be in an amount equal to at least Fifty Thousand Dollars
($50,000.00). After repayment, no Equipment Advance may be reborrowed. 

        (b)    Repayment.    Commencing on April 1, 2007, and continuing on the Payment Date of each month thereafter,
Equipment Advances outstanding on the expiration of the Draw Period are payable in: (i) thirty-six (36) consecutive equal monthly installments of principal, plus
(ii) monthly payments of accrued interest at the rate set forth in Section 2.2(a)(ii). All unpaid principal and accrued interest is due and payable in full on the Equipment Maturity
Date. Payments received after 12:00 noon Eastern time are considered received at the opening of business on the next Business Day. 

        (c)    Final Payment.    On the earlier of (i) the Equipment Maturity Date, or (ii) the acceleration of
the Equipment Line following an Event of Default, Borrower shall pay, in addition to the outstanding principal, accrued and unpaid interest, and all other amounts due on such date with respect to the
Equipment Advances, an amount equal to the Final Payment. 

 

        (d)    Prepayment Upon an Event of Loss.    Borrower shall bear the risk of any loss, theft, destruction, or damage of
or to the Financed Equipment. If during the term of this Agreement any item of Financed Equipment becomes obsolete or is lost, stolen, destroyed, damaged beyond repair, rendered permanently unfit for
use, or seized by a governmental authority for any reason for a period equal to at least the remainder of the term of this Agreement (an "Event of
Loss"), then if no Event of Default has occurred or is continuing, within ten (10) days following the Event of Loss, at Borrower's option, Borrower shall (i) pay
to Bank, with respect to the Financed Equipment subject to the Event of Loss, the outstanding principal balance of the Equipment Advances used to finance such Financed Equipment together with all
accrued and unpaid interest thereon to the date of the prepayment, and the Final Payment solely with respect to such Equipment Advance; or (ii) repair or replace any Financed Equipment subject
to the Event of Loss provided the repaired or replaced Financed Equipment is of equal or like value to the Financed Equipment subject to the Event of Loss and
provided further that Bank has a first priority perfected security interest in such repaired or replaced Financed Equipment. 

        (e)    Mandatory Prepayment Upon an Acceleration.    If the Equipment Advances are accelerated in accordance with
Section 9 following the occurrence of an Event of Default, Borrower shall immediately pay to Bank an amount equal to the sum of (i) all outstanding principal plus accrued and unpaid
interest, (ii) the Final Payment, and (iii) all other sums, if any, that shall have become due and payable, including interest at the Default Rate with respect to any past due amounts,
in each case, with respect to the Equipment Advances. 

        (f)    Permitted Prepayment of Equipment Advances.    Borrower shall have the option to prepay all, but not less than
all, of any such Equipment Advance advanced by Bank under this Agreement, provided Borrower (i) delivers written notice to Bank of its election to prepay such Equipment Advance at least ten
(10) days prior to such prepayment, and (ii) pays, on the date of such prepayment (A) all outstanding principal plus accrued and unpaid interest, (B) the Final Payment, and
(C) all other sums, if any, that shall have become due and payable, including interest at the Default Rate with respect to any past due amounts, with respect to such Equipment Advance. 

        2.2    Payment of Interest on the Credit Extensions.    

        (a)    Interest Rate.    

          (i)  Draw
Period. During the Draw Period, subject to Section 2.2(b), the principal amount outstanding for the Equipment Advances shall accrue interest at a floating
per annum rate equal to one-quarter of one percentage point (0.25%) above the Prime Rate, which interest shall be payable monthly. 

         (ii)  Principal
Repayment Period. Commencing on April 1, 2007, subject to Section 2.2(b), the principal amount outstanding for the Equipment Advances shall
accrue interest at a fixed per annum rate equal to one-quarter of one percentage point (0.25%) above the Prime Rate, determined by Bank as of January 1, 2007, which interest shall
be payable monthly. 

        (b)    Default Rate.    Immediately upon the occurrence and during the continuance of an Event of Default, Obligations
shall bear interest at a rate per annum which is four percentage points above the rate effective immediately before the Event of Default (the "Default
Rate"). Payment or acceptance of the increased interest rate provided in this Section 2.2(b) is not a permitted alternative to timely payment and shall not constitute a
waiver of any Event of Default or otherwise prejudice or limit any rights or remedies of Bank. 

        (c)    Adjustment to Interest Rate During the Draw Period.    Changes to the interest rate of any Credit Extension
based on changes to the Prime Rate during the Draw Period shall be effective on the effective date of any change to the Prime Rate and to the extent of any such change. 

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        (d)    360-Day Year.    Interest shall be computed on the basis of a 360-day year for the
actual number of days elapsed. 

        (e)    Debit of Accounts.    Bank may debit any of Borrower's Deposit Accounts, including the Designated Deposit
Account, for (i) principal and interest payments when due in accordance with this Agreement without notice or (ii) any other amounts Borrower owes Bank when due in accordance with this
Agreement after Bank provides notice of such amounts. These debits shall not constitute a set-off. 

        (f)    Payments.    Unless otherwise provided, interest is payable monthly on the Payment Date of each month. Payments
of principal and/or interest received after 2:00 p.m. Eastern time are considered received at the opening of business on the next Business Day. When a payment is due on a day that is not a
Business Day, the payment is due the next Business Day and additional fees or interest, as applicable, shall continue to accrue. 

        2.3    Fees.    Borrower shall pay to Bank: 

        (a)    Final Payment.    The Final Payment, when due hereunder; 

        (b)    Bank Expenses.    All Bank Expenses (including reasonable attorneys' fees and expenses, plus expenses, for
documentation and negotiation of this Agreement) incurred through and after the Effective Date, when due. 

        2.4    Additional Costs.    If any law or regulation increases Bank's
costs or reduces its income for any loan, Borrower shall pay the increase in cost or reduction in income or additional expense; provided, however, that Borrower shall not be liable for any amount
attributable to any period before 180 days prior to the date Bank notifies Borrower of such increased costs. Bank agrees that it shall allocate any increased costs among its customers similarly
affected in good faith and in a manner consistent with Bank's customary practice. The terms of this Section 2.4 shall only apply to Credit Extensions with fixed rates of interest. 

        3    CONDITIONS OF LOANS    

        3.1    Conditions Precedent to Initial Credit Extension.    Bank's
obligation to make the initial Credit Extension is subject to the condition precedent that Bank shall have received, in form and substance satisfactory to Bank, the following documents, including,
without limitation: 

        (a)   Duly
executed original signatures to the Loan Documents to which it is a party; 

        (b)   Borrower
shall have delivered its Operating Documents and a good standing certificate of Borrower certified by the Secretary of State of the State of Delaware as of a
date no earlier than thirty (30) days prior to the Effective Date; 

        (c)   Duly
executed original signatures to the completed Borrowing Resolutions for Borrower; 

        (d)   Bank
shall have received certified copies, dated as of a recent date, of financing statement searches, as Bank shall request, accompanied by written evidence (including
any UCC termination statements) that the Liens indicated in any such financing statements either constitute Permitted Liens or have been or, in connection with the initial Credit Extension, will be
terminated or released; 

        (e)   Borrower
shall have delivered a landlord's consent in favor of Bank in the form attached hereto as Exhibit C; 

        (f)    Borrower
shall have delivered a legal opinion of Borrower's counsel dated as of the Effective Date together with the duly executed original signatures thereto; 

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        (g)   Borrower
shall have delivered evidence satisfactory to Bank that the insurance policies required by Section 6.5 hereof are in full force and effect, together with
appropriate evidence showing loss payable and/or additional insured clauses or endorsements in favor of Bank; and 

        (h)   Borrower
shall have paid the Bank Expenses then due as specified in Section 2.3 hereof. 

        3.2    Conditions Precedent to all Credit Extensions.    Bank's
obligations to make each Credit Extension, including the initial Credit Extension, is subject to the following: 

        (a)   except
as otherwise provided in Section 3.4, timely receipt of an executed Payment/Advance Form and a UCC financing statement covering the Financed Equipment
described on Annex A to the Exhibit A attached hereto; 

        (b)   the
representations and warranties in Section 5 shall be true in all material respects on the date of the Payment/Advance Form and on the Funding Date of each
Credit Extension; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text
thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date, and no
Default or Event of Default shall have occurred and be continuing or result from the Credit Extension. Each Credit Extension is Borrower's representation and warranty on that date that the
representations and warranties in Section 5 remain true in all material respects; provided, however, that such materiality qualifier shall not be applicable to any representations and
warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be
true, accurate and complete in all material respects as of such date; 

        (c)   confirmation
that upon filing the UCC financing statement covering the Financed Equipment described on Annex A to the Exhibit A attached hereto, that the
Bank shall have a first perfected security interest in such Financed Equipment; and 

        (d)   in
Bank's reasonable discretion, there has not been any material impairment in the general affairs, management, results of operation, financial condition or the prospect
of repayment of the Obligations, or there has not been any material adverse deviation by Borrower from the most recent business plan of Borrower presented to and accepted by Bank. 

        3.3    Covenant to Deliver.    Borrower agrees to deliver to Bank each
item required to be delivered to Bank under this Agreement as a condition to any Credit Extension. Borrower expressly agrees that the extension of a Credit Extension prior to the receipt by Bank of
any such item shall not constitute a waiver by Bank of Borrower's obligation to deliver such item, and any such extension in the absence of a required item shall be in Bank's sole discretion. 

        3.4    Procedures for Borrowing.    Subject to the prior satisfaction
of all other applicable conditions to the making of an Equipment Advance set forth in this Agreement, to obtain an Equipment Advance, Borrower must notify Bank (which notice shall be irrevocable) by
electronic mail or facsimile no later
than 12:00 p.m. Eastern time one (1) Business Day before the proposed Funding Date. The notice shall be a Payment/Advance Form, must be signed by a Responsible Officer or designee, and
shall include a copy of the invoice for the Equipment being financed, together with a UCC Financing Statement authorization covering the Financed Equipment described on Annex A to the
Exhibit A and such additional information as Bank may reasonably request at least five (5) Business Days before the proposed Funding Date. 

        4    CREATION OF SECURITY INTEREST    

        4.1    Grant of Security Interest.    Borrower hereby grants Bank, to
secure the payment and performance in full of all of the Obligations, a continuing security interest in, and pledges to Bank, the 

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Collateral,
wherever located, whether now owned or hereafter acquired or arising, and all proceeds and products thereof. Borrower represents, warrants, and covenants that the security interest granted
herein is and shall at all times continue to be a first priority perfected security interest in the Collateral. 

        If
this Agreement is terminated, Bank's Lien in the Collateral shall continue until the Obligations (other than inchoate indemnity obligations) are repaid in full in cash. Upon payment
in full in cash of the Obligations and at such time as Bank's obligation to make Credit Extensions has terminated, Bank shall, at Borrower's sole cost and expense, release its Liens in the Collateral
and all rights therein shall revert to Borrower. 

        4.2    Authorization to File Financing Statements.    Borrower hereby
authorizes Bank to file financing statements with respect to the Financed Equipment, without notice to Borrower, with all appropriate jurisdictions to perfect or protect Bank's interest or rights
hereunder, including a notice that any disposition of the Collateral, by either Borrower or any other Person, shall be deemed to violate the rights of Bank under the Code. 

        5    REPRESENTATIONS AND WARRANTIES    

        Borrower
represents and warrants as follows: 

        5.1    Due Organization and Authorization.    Borrower and each of its
Subsidiaries are duly existing and in good standing, as Registered Organizations in their respective jurisdictions of formation and are qualified and licensed to do business and are in good standing
in any jurisdiction in which the conduct of their business or their ownership of property requires that they be qualified except where the failure
to do so could not reasonably be expected to have a material adverse effect on Borrower's business. In connection with this Agreement, Borrower has delivered to Bank a completed certificate signed by
Borrower (the "Perfection Certificate"). Borrower represents and warrants to Bank that (a) Borrower's exact legal name is that indicated on the Perfection Certificate and on the signature page
hereof; (b) Borrower is an organization of the type and is organized in the jurisdiction set forth in the Perfection Certificate; (c) the Perfection Certificate accurately sets forth
Borrower's organizational identification number or accurately states that Borrower has none; (d) the Perfection Certificate accurately sets forth Borrower's place of business, or, if more than
one, its chief executive office as well as Borrower's mailing address (if different than its chief executive office); (e) Borrower (and each of its predecessors) has not, in the past five
(5) years, changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its jurisdiction; and (f) all other information set forth on
the Perfection Certificate pertaining to Borrower and each of its Subsidiaries is accurate and complete. If Borrower is not now a Registered Organization but later becomes one, Borrower shall promptly
notify Bank of such occurrence and provide Bank with Borrower's organizational identification number. 

        The
execution, delivery and performance of the Loan Documents have been duly authorized, and do not conflict with Borrower's organizational documents, nor constitute an event of default
under any material agreement by which Borrower is bound. Borrower is not in default under any agreement to which it is a party or by which it is bound in which the default could reasonably be expected
to have a material adverse effect on Borrower's business. 

        5.2    Collateral.    Borrower has good title to, has rights in, and
the power to transfer each item of the Collateral upon which it purports to grant a Lien hereunder, free and clear of any and all Liens except Permitted Liens. 

        The
Collateral is not in the possession of any third party bailee (such as a warehouse) except as otherwise provided in the Perfection Certificate. None of the components of the
Collateral shall be maintained at locations other than as provided in the Perfection Certificate or as Borrower has given Bank notice pursuant to Section 7.2. In the event that Borrower, after
the date hereof, intends to store or otherwise deliver any portion of the Collateral to a bailee, then Borrower will first receive the 

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written
consent of Bank and such bailee must execute and deliver a bailee agreement in form and substance satisfactory to Bank in its sole discretion. 

        5.3    Litigation.    There are no actions or proceedings pending or,
to the knowledge of the Responsible Officers, threatened in writing by or against Borrower or any of its Subsidiaries involving more than Fifty Thousand Dollars ($50,000.00). 

        5.4    No Material Deviation in Financial Statements.    All
consolidated financial statements for Borrower and any of its Subsidiaries delivered to Bank fairly present in all material respects Borrower's consolidated financial condition and Borrower's
consolidated results of operations. There has not been any material deterioration in Borrower's consolidated financial condition since the date of the most recent financial statements submitted to
Bank. 

        5.5    Solvency.    The fair salable value of Borrower's assets
(including goodwill minus disposition costs) exceeds the fair value of its liabilities; Borrower is not left with unreasonably small capital after the transactions in this Agreement; and Borrower is
able to pay its debts (including trade debts) as they mature. 

        5.6    Regulatory Compliance.    Borrower is not an "investment
company" or a company "controlled" by an "investment company" under the Investment Company Act. Borrower is not engaged as one of its important activities in extending credit for margin stock (under
Regulations T and U of the Federal Reserve Board of Governors). Borrower has complied in all material respects with the Federal Fair Labor Standards Act. Borrower has not violated any laws, ordinances
or rules, the violation of which could reasonably be expected to have a material adverse effect on its business. None of Borrower's or any of its Subsidiaries' properties or assets has been used by
Borrower or any Subsidiary or, to the best of Borrower's knowledge, by previous Persons, in disposing, producing, storing, treating, or transporting any hazardous substance other than legally.
Borrower and each of its Subsidiaries have obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all government authorities that are
necessary to continue its business as currently conducted. 

        5.7    Subsidiaries; Investments.    Borrower does not own any stock,
partnership interest or other equity securities except for Permitted Investments. 

        5.8    Tax Returns and Payments; Pension Contributions.    Borrower
has timely filed all required tax returns and reports, and Borrower and its Subsidiaries have timely paid all foreign, federal, state and local taxes, assessments, deposits and contributions owed by
Borrower. Borrower may defer payment of any contested taxes, provided that Borrower (a) in good faith contests its obligation to pay the taxes by appropriate proceedings promptly and diligently
instituted and conducted, (b) notifies Bank in writing of the commencement of, and any material development in, the proceedings, (c) posts bonds or takes any other steps required to
prevent the governmental authority levying such contested taxes from obtaining a Lien upon any of the Collateral that is other than a "Permitted Lien". Borrower is unaware of any claims or adjustments
proposed for any of Borrower's prior tax years which could result in additional taxes becoming due and payable by Borrower. Borrower has paid all amounts necessary to fund all present pension, profit
sharing and deferred compensation plans in accordance with their terms, and Borrower has not withdrawn from participation in, and has not permitted partial or complete termination of, or permitted the
occurrence of any other event with respect to, any such plan which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty
Corporation or its successors or any other governmental agency. 

        5.9    Use of Proceeds.    Borrower shall use the proceeds of the
Credit Extensions solely to purchase Eligible Equipment, and to fund its general business requirements and not for personal, family, household or agricultural purposes. 

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        5.10    Full Disclosure.    No written representation, warranty or
other statement of Borrower in any certificate or written statement given to Bank, as of the date such representations, warranties, or other statements were made, taken together with all such written
certificates and written statements given to Bank, contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements contained in the certificates or
statements not misleading (it being recognized by Bank that the projections and forecasts provided by Borrower in good faith and based upon reasonable assumptions are not viewed as facts and that
actual results during the period or periods covered by such projections and forecasts may differ from the projected or forecasted results). 

        6    AFFIRMATIVE COVENANTS    

        Borrower
shall do all of the following: 

        6.1    Government Compliance.    Maintain its and all its
Subsidiaries' legal existence and good standing in their respective jurisdictions of formation and maintain qualification in each jurisdiction in which the failure to so qualify would reasonably be
expected to have a material adverse effect on Borrower's business or operations. Borrower shall comply, and have each Subsidiary comply, with all laws, ordinances and regulations to which it is
subject, the noncompliance with which could have a material adverse effect on Borrower's business. 

        6.2    Financial Statements, Reports, Certificates.    Deliver to
Bank: (i) as soon as available, but no later than thirty (30) days after the last day of each month, a company prepared consolidated balance sheet and income statement covering
Borrower's consolidated operations during the previous month certified by a Responsible Officer and in a form acceptable to Bank; (ii) contemporaneously with Borrower's delivery to Borrower's
Board of Directors, but in any event no later than one hundred twenty (120) days after the last day of Borrower's fiscal year (with the exception of fiscal year end 2005, which shall be
delivered to the Bank on or before June 30, 2006), audited consolidated financial statements prepared under GAAP, consistently applied, together with an unqualified opinion on the financial
statements from an independent certified public accounting firm acceptable to Bank in its reasonable discretion; (iii) within five (5) days of delivery, copies of all statements, reports
and notices made available to Borrower's security holders; (iv) in the event that Borrower becomes subject to the reporting requirements under the Securities Exchange Act of 1934, as amended,
within five (5) days of filing, all reports on Form 10-K, 10-Q and 8-K filed with the Securities and Exchange Commission or a link thereto on
Borrower's or another website on the internet; (v) a prompt report of any legal actions pending or threatened against Borrower or any of its
Subsidiaries that could result in damages or costs to Borrower or any of its Subsidiaries of Fifty Thousand Dollars ($50,000) or more; and (vi) budgets, sales projections, operating plans and
other financial information reasonably requested by Bank. 

        6.3    Intentionally Deleted.    

        6.4    Taxes; Pensions.    Make, and cause each of its Subsidiaries to
make, timely payment of all foreign, federal, state, and local taxes or assessments (other than taxes and assessments which Borrower is contesting pursuant to the terms of Section 5.8 hereof)
and shall deliver to Bank, on demand, appropriate certificates attesting to such payments, and pay all amounts necessary to fund all present pension, profit sharing and deferred compensation plans in
accordance with their terms. 

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        6.5    Insurance.    Keep its business and the Collateral insured for
risks and in amounts standard for companies in Borrower's industry and location and as Bank may reasonably request. Insurance policies shall be in a form, with companies, and in amounts that are
satisfactory to Bank. All property policies relating to the Collateral shall have a lender's loss payable endorsement showing Bank as the loss payee and waive subrogation against Bank, and all
liability policies shall show, or have endorsements showing, Bank as an additional insured. All policies (or the loss payable and additional insured endorsements) shall provide that the insurer must
give Bank at least twenty (20) days notice before canceling, amending, or declining to renew its policy. At Bank's request, Borrower shall deliver certified copies of policies relating to the
Collateral and evidence of all premium payments. Proceeds payable under any such policy relating to the Collateral shall, at Bank's option, be payable to Bank on account of the Obligations.
Notwithstanding the foregoing, (a) so long as no Event of Default has occurred and is continuing, Borrower shall have the option of applying the proceeds of any casualty policy up to $50,000,
in the aggregate, toward the replacement or repair of destroyed or damaged property; provided that any such replaced or repaired property (i) shall be of equal or like value as the replaced or
repaired Collateral and (ii) shall be deemed Collateral in which Bank has been granted a first priority security interest, and (b) after the occurrence and during the continuance of an
Event of Default, all proceeds payable under such casualty policy shall, at the option of Bank, be payable to Bank on account of the Obligations. If Borrower fails to obtain insurance as required
under this Section 6.5 or to pay any amount or furnish any required proof of payment to third persons and Bank, Bank may make all or part of such payment or obtain such insurance policies
required in this Section 6.5, and take any action under the policies Bank deems prudent. 

        6.6    Operating Accounts.    Maintain its primary operating account
with Bank and a portion of Borrower's cash or securities in excess of that amount used for Borrower's operations shall be maintained at Bank and/or Bank's affiliates. 

        6.7    Litigation Cooperation.    From the date hereof and continuing
through the termination of this Agreement, make available to Bank, without expense to Bank, Borrower and its officers, employees and agents and Borrower's books and records, to the extent that Bank
may deem them reasonably necessary to prosecute or defend any third-party suit or proceeding instituted by or against Bank with respect to any Collateral or relating to Borrower. 

        6.8    Further Assurances.    Borrower shall execute any further
instruments and take further action as Bank reasonably requests to perfect or continue Bank's Lien in the Collateral or to effect the purposes of this Agreement. 

        7    NEGATIVE COVENANTS    

        Borrower
shall not do any of the following without Bank's prior written consent: 

        7.1    Dispositions.    Convey, sell, lease, transfer or otherwise
dispose of (collectively, "Transfer"), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, except for Transfers
(a) of Inventory in the ordinary course of business; (b) of worn-out or obsolete Equipment, or other Equipment which is not Financed Equipment which is sold by the Borrower
in the ordinary course of business, which Borrower determines in its reasonable judgment that such Equipment is not necessary to the Borrower's business; (c) in connection with Permitted Liens
and Permitted Investments; and (d) of licenses and similar arrangements for use of intellectual property in the ordinary course of business. 

        7.2    Changes in Business, Management, Ownership, or Business
Locations.    (a) Engage in or permit any of its Subsidiaries to engage in any business other than the businesses currently engaged in by Borrower and such
Subsidiary, as applicable, or reasonably related thereto; (b) liquidate or dissolve; or (c) (i)(A) if all of the Key Persons resign, are terminated, or are no longer actively
involved in the management of the Borrower in their current positions, or (B) if any two (2) out of the three (3) Key 

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Persons
resign, are terminated, or are no longer actively involved in the management of the Borrower in their current positions and a replacement reasonably satisfactory to Bank for at least one of
such Key Persons is not made within sixty (60) days after departure from Borrower, and the replacement reasonably satisfactory to Bank for the other such Key Persons is not made within one
hundred eighty (180) days after departure from Borrower (which time period may be extended by Bank in the Bank's reasonable discretion); or (ii) enter into any transaction or series of
related transactions in which the stockholders of Borrower immediately prior to the first such transaction own less than 50% of the voting stock of Borrower immediately after giving effect to such
transaction or related series of such transactions (other than by the sale of Borrower's equity securities in a public offering or to venture capital investors so long as Borrower identifies to Bank
the venture capital investors prior to the closing of the transaction). Borrower shall not, without at least thirty (30) days prior written notice to Bank: (1) change its jurisdiction of
organization, (2) change its organizational structure or type, (3) change its legal name, or (4) change any organizational number (if any) assigned by its jurisdiction of
organization. 

        7.3    Mergers or Acquisitions.    Without the Bank's prior written
consent, which shall not be unreasonably withheld or delayed, merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other Person, or acquire, or permit any of its
Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person. A Subsidiary may merge or consolidate into another Subsidiary or into Borrower. 

        7.4    Indebtedness.    Create, incur, assume, or be liable for any
Indebtedness, or permit any Subsidiary to do so, other than Permitted Indebtedness. 

        7.5    Encumbrance.    Create, incur, or allow any Lien on any of its
property, or assign or convey any right to receive income, including the sale of any Accounts or permit any of its Subsidiaries to do so, except for Permitted Liens, or permit any Collateral not to be
subject to the first priority security interest granted herein. 

        7.6    Intentionally Deleted.    

        7.7    Distributions; Investments.    (a) Directly or
indirectly make any Investment other than Permitted Investments, or permit any of its Subsidiaries to do so; or (b) pay any dividends or make any distribution or payment or redeem, retire or
purchase any capital stock, provided that (i) Borrower may convert any of its convertible securities into other securities pursuant to the terms of such convertible securities or otherwise in
exchange thereof, (ii) Borrower may pay dividends solely in capital stock; and (iii) Borrower may repurchase the stock of former employees or consultants pursuant to stock repurchase
agreements so long as an Event of Default does not exist at the time of such repurchase and would not exist after giving effect to such repurchase, provided that, without the Bank's prior written
consent, which shall not be unreasonably withheld or delayed, such repurchase does not exceed in the aggregate of Two Hundred Fifty Thousand Dollars
($250,000.00) per fiscal year. 

        7.8    Transactions with Affiliates.    Directly or indirectly enter
into or permit to exist any material transaction with any Affiliate of Borrower, except for transactions that are in the ordinary course of Borrower's business, upon fair and reasonable terms that are
no less favorable to Borrower than would be obtained in an arm's length transaction with a non-affiliated Person, except for employee loans of up to a maximum amount of Two Hundred Fifty
Thousand Dollars ($250,000.00), in the aggregate outstanding at any time. 

        7.9    Subordinated Debt.    (a) Make or permit any payment on
any Subordinated Debt, except under the terms of the subordination, intercreditor, or other similar agreement to which such Subordinated Debt is subject, or (b) amend any provision in any
document relating to the Subordinated Debt which would increase the amount thereof or adversely affect the subordination thereof to Obligations owed to Bank. 

9

 

        7.10    Compliance.    Become an "investment company" or a company
controlled by an "investment company", under the Investment Company Act of 1940 or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in
Regulation U of the Board of Governors of the Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA,
permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; fail to comply with the Federal Fair Labor
Standards Act or violate any other law or regulation, if the violation could reasonably be expected to have a material adverse effect on Borrower's business, or permit any of its Subsidiaries to do
so; withdraw or permit any Subsidiary to withdraw from participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any present pension,
profit sharing and deferred compensation plan which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or its
successors or any other governmental agency. 

        8    EVENTS OF DEFAULT    

        Any
one of the following shall constitute an event of default (an "Event of Default") under this Agreement: 

        8.1    Payment Default.    Borrower fails to (a) make any
payment of principal or interest on any Credit Extension on its due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable
(which three day grace period will not apply to payments due on the Maturity Date). During the grace period, the failure to cure the payment default is not an Event of Default (but no Credit Extension
will be made during the cure period); 

        8.2    Covenant Default.    

        (a)   Borrower
fails or neglects to perform any obligation in Sections 6.2, 6.6 or violates any covenant in Section 7; or 

        (b)   Borrower
fails or neglects to perform, keep, or observe any other term, provision, condition, covenant or agreement contained in this Agreement, any Loan Documents, and
as to any default (other than those specified in this Section 8 below) under such other term, provision, condition, covenant or agreement that can be cured, has failed to cure the default
within ten (10) days after the occurrence thereof; provided, however, that if the default cannot by its nature be cured within the ten (10) day period or cannot after diligent attempts
by Borrower be cured within such ten (10) day period, and such default is likely to be cured within a reasonable time, then Borrower shall have an additional period (which without the prior
written consent of Bank, shall not in any case exceed thirty (30) days) to attempt to cure such default, and within such reasonable time period the failure to cure the default shall not be
deemed an Event of Default (but no Credit Extensions shall be made during such cure period); 

        8.3    Material Adverse Change.    A Material Adverse Change occurs; 

        8.4    Attachment.    (a) Any material portion of Borrower's
assets is attached, seized, levied on, or comes into possession of a trustee or receiver and the attachment, seizure or levy is not removed in ten (10) days; (b) the service of process
upon Bank (or Bank's Affiliate) seeking to attach, by trustee or similar process, any funds of, or of any entity under control of Borrower (including a Subsidiary) on deposit with the Bank;
(c) Borrower is enjoined, restrained, or prevented by court order from conducting a material part of its business; (d) a judgment or other claim in excess of One Hundred Thousand Dollars
($100,000.00) becomes a Lien on any of Borrower's assets; or (e) a notice of lien, levy, or assessment is filed against any of Borrower's assets by any government agency and not paid within ten
(10) days after Borrower receives notice. These are not Events of Default if stayed or if a bond is posted pending contest by Borrower (but no Credit Extensions shall be made during the cure
period); 

10

 

        8.5    Insolvency    (a) Borrower is unable to pay its debts
(including trade debts) as they become due or otherwise becomes insolvent; (b) Borrower begins an Insolvency Proceeding; or (c) an Insolvency Proceeding is begun against Borrower and not
dismissed or stayed within thirty (30) days (but no Credit Extensions shall be made while of any of the conditions described in clause (a) exist and/or until any Insolvency Proceeding is
dismissed); 

        8.6    Other Agreements.    There is a default in any agreement to
which Borrower is a party with a third party or parties resulting in the acceleration of the maturity of any Indebtedness in an amount in excess of Two Hundred Fifty Thousand Dollars ($250,000) or
that could have a material adverse effect on Borrower's business; 

        8.7    Judgments.    A judgment or judgments for the payment of money
in an amount, individually or in the aggregate, of at least One Hundred Thousand Dollars ($100,000) (not covered by independent third-party insurance) shall be rendered against Borrower and shall
remain unsatisfied and unstayed for a period of ten (10) days after the entry thereof (provided that no Credit Extensions will be made prior to the satisfaction or stay of such judgment); 

        8.8    Misrepresentations.    Borrower or any Person acting for
Borrower makes any representation, warranty, or other statement now or later in this Agreement, any Loan Document or in any writing delivered to Bank or to induce Bank to enter this Agreement or any
Loan Document, and such representation, warranty, or other statement is incorrect in any material respect when made; or 

        8.9    Subordinated Debt.    A default or breach occurs under any
agreement between Borrower and any creditor of Borrower that signed a subordination, intercreditor, or other similar agreement with Bank, or any creditor that has signed such an agreement with Bank
breaches any terms of such agreement, in any material respect. 

        9    BANK'S RIGHTS AND REMEDIES    

        9.1    Rights and Remedies.    While an Event of Default occurs and
continues Bank may, without notice or demand, do any or all of the following: 

        (a)   declare
all Obligations immediately due and payable (but if an Event of Default described in Section 8.5 occurs all Obligations are immediately due and payable
without any action by Bank); 

        (b)   stop
advancing money or extending credit for Borrower's benefit under this Agreement; 

        (c)   make
any payments and do any acts it considers necessary or reasonable to protect its security interest in the Collateral. Borrower shall assemble the Collateral if Bank
requests and make it available as Bank designates. Bank may enter premises where the Collateral is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or
compromise any Lien which appears to be prior or superior to its security interest and pay all expenses incurred. Borrower grants Bank a license to enter and occupy any of its premises, without
charge, to exercise any of Bank's rights or remedies; 

        (d)   apply
to the Obligations any (i) balances and deposits of Borrower it holds, or (ii) any amount held by Bank owing to or for the credit or the account of
Borrower; 

        (e)   demand
and receive possession of Borrower's Books; and 

        (f)    exercise
all rights and remedies available to Bank under the Loan Documents or at law or equity, including all remedies provided under the Code (including disposal of
the Collateral pursuant to the terms thereof). 

        9.2    Power of Attorney.    Borrower hereby irrevocably appoints Bank
as its lawful attorney-in-fact, exercisable upon the occurrence and during the continuance of an Event of Default, to: (a) make, settle, and adjust all claims under
Borrower's casualty insurance policies; and (b) transfer the Collateral 

11

 

into
the name of Bank or a third party as the Code permits. Borrower hereby appoints Bank as its lawful attorney-in-fact to sign Borrower's name on any documents necessary to
perfect or continue the perfection of any security interest regardless of whether an Event of Default has occurred until all Obligations have been satisfied in full and Bank is under no further
obligation to make Credit Extensions hereunder. Bank's foregoing appointment as Borrower's attorney in fact, and all of Bank's rights and powers, coupled with an interest, are irrevocable until all
Obligations have been fully repaid and performed and Bank's obligation to provide Credit Extensions terminates. 

        9.3    Intentionally Deleted.    

        9.4    Protective Payments.    If Borrower fails to obtain the
insurance called for by Section 6.5 or fails to pay any premium thereon or fails to pay any other amount which Borrower is obligated to pay under this Agreement or any other Loan Document, Bank
may obtain such insurance or make such payment, and all amounts so paid by Bank are Bank Expenses and immediately due and payable, bearing interest at the then highest applicable rate, and secured by
the Collateral. Bank will make reasonable efforts to provide Borrower with notice of Bank obtaining such insurance at the time it is obtained or within a reasonable time thereafter. No payments by
Bank are deemed an agreement to make similar payments in the future or Bank's waiver of any Event of Default. 

        9.5    Application of Payments and Proceeds.    If an Event of Default
has occurred and is continuing, Bank may apply any funds in its possession, from payments and proceeds realized as the result of any disposition of the Collateral, to the Obligations in such order as
Bank shall determine in its sole discretion. Any surplus shall be paid to Borrower or other Persons legally entitled thereto; Borrower shall remain liable to Bank for any deficiency. If Bank, in its
good faith business judgment, directly or indirectly enters into a deferred payment or other credit transaction with any purchaser at any sale of Collateral, Bank shall have the option, exercisable at
any time, of either reducing the Obligations by the principal amount of the purchase price or deferring the reduction of the Obligations until the actual receipt by Bank of cash therefor. 

        9.6    Bank's Liability for Collateral.    So long as Bank complies
with reasonable banking practices regarding the safekeeping of the Collateral in the possession or under the control of Bank, Bank shall not be liable or responsible for: (a) the safekeeping of
the Collateral; (b) any loss or damage to the Collateral; (c) any diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or
other Person. Borrower bears all risk of loss, damage or destruction of the Collateral. 

        9.7    No Waiver; Remedies Cumulative.    Bank's failure, at any time
or times, to require strict performance by Borrower of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Bank thereafter to demand strict
performance and compliance herewith or therewith. No waiver hereunder shall be effective unless signed by Bank and then is only effective for the specific instance and purpose for which it is given.
Bank's rights and remedies under this Agreement and the other Loan Documents are cumulative. Bank has all rights and remedies provided under the Code, by law, or in equity. Bank's exercise of one
right or remedy is not an election, and Bank's waiver of any Event of Default is not a continuing waiver. Bank's delay in exercising any remedy is not a waiver, election, or acquiescence. 

        9.8    Demand Waiver.    Borrower waives demand, notice of default or
dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper,
and guarantees held by Bank on which Borrower is liable. 

        10    NOTICES    

        All
notices, consents, requests, approvals, demands, or other communication (collectively, "Communication") by any party to this Agreement
or any other Loan Document must be in writing 

12

 

and
shall be deemed to have been validly served, given, or delivered: (a) upon the earlier of actual receipt and three (3) Business Days after deposit in the U.S. mail, first class,
registered or certified mail return receipt requested, with proper postage prepaid; (b) upon transmission, when sent by electronic mail or facsimile transmission; (c) one
(1) Business Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if hand-delivered by messenger, all of which shall be
addressed to the party to be notified and sent to the address, facsimile number, or email address indicated below. Bank or Borrower may change its address, email address, or facsimile number by giving
the other party written notice thereof in accordance with the terms of this Section 10. 

	 	If to Borrower:	 	Sirtris Pharmaceuticals, Inc.

790 Memorial Drive, Suite 104

Cambridge, Massachusetts 02139

Attn: Vice President of Finance

Fax: (617) 252-6924

Email: pbrannelly@sitrispharma.com
	

 	

with a copy to:	
 	

Ropes & Gray LLP

One International Place

Boston, Massachusetts 02110

Attn: Marc A. Rubenstein, Esquire

Fax: (617) 951-7050

Email: marc.rubenstein@ropesgray.com
	

 	

If to Bank:	
 	

Silicon Valley Bank

One Newton Executive Park, Suite 200

2221 Washington Street

Newton, Massachusetts 02462

Attn: Ms. Bernadette Michaud

Fax: (617) 969-5973

Email: bmichaud@svbank.com
	

 	

with a copy to:	
 	

Riemer & Braunstein LLP

Three Center Plaza

Boston, Massachusetts 02108

Attn: David A. Ephraim, Esquire

Fax: (617) 880-3456

Email: DEphraim@riemerlaw.com

13

   
        11    CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER AND JUDICIAL
REFERENCE    

        Massachusetts
law governs the Loan Documents without regard to principles of conflicts of law. Borrower and Bank each submit to the exclusive jurisdiction of the State and Federal courts
in Massachusetts; provided, however, that if for any reason Bank cannot avail itself of such courts in the Commonwealth of Massachusetts, Borrower accepts jurisdiction of the courts and venue in Santa
Clara County, California. NOTWITHSTANDING THE FOREGOING, BANK SHALL HAVE THE RIGHT TO BRING ANY ACTION OR PROCEEDING AGAINST BORROWER OR ITS PROPERTY IN THE COURTS OF ANY OTHER JURISDICTION WHICH BANK
DEEMS NECESSARY OR APPROPRIATE IN ORDER TO REALIZE ON THE COLLATERAL OR TO OTHERWISE ENFORCE BANK'S RIGHTS AGAINST BORROWER OR ITS PROPERTY. 

TO THE EXTENT PERMITTED BY APPLICABLE LAW, BORROWER AND BANK EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT,
THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO THIS AGREEMENT.
EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 

        12    GENERAL PROVISIONS    

        12.1    Successors and Assigns.    This Agreement binds and is for the
benefit of the successors and permitted assigns of each party. Borrower may not assign this Agreement or any rights or obligations under it without Bank's prior written consent (which may be granted
or withheld in Bank's discretion). Bank has the right, without the consent of or notice to Borrower, to sell, transfer, negotiate, or grant participation in all or any part of, or any interest in,
Bank's obligations, rights, and benefits under this Agreement and the other Loan Documents. Prior to an Event of Default, the Bank may only assign this Agreement to a commercial bank or financial
institution, which is not a direct competitor of Borrower. 

        12.2    Indemnification.    Borrower agrees to indemnify, defend and
hold Bank and its directors, officers, employees, agents, attorneys, or any other Person affiliated with or representing Bank harmless against: (a) all obligations, demands, claims, and
liabilities (collectively, "Claims") asserted by any other party in connection with the transactions contemplated by the Loan Documents; and (b) all losses or Bank Expenses incurred, or paid by
Bank from, following, or arising from transactions between Bank and
Borrower (including reasonable attorneys' fees and expenses), except for Claims and/or losses directly caused by Bank's gross negligence or willful misconduct. 

        12.3    Intentionally Deleted.    

        12.4    Time of Essence.    Time is of the essence for the performance
of all Obligations in this Agreement. 

        12.5    Severability of Provisions.    Each provision of this
Agreement is severable from every other provision in determining the enforceability of any provision. 

        12.6    Amendments in Writing; Integration.    All amendments to this
Agreement must be in writing signed by both Bank and Borrower. This Agreement and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or
agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Agreement and the Loan Documents merge into this
Agreement and the Loan Documents. 

        12.7    Counterparts.    This Agreement may be executed in any number
of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, are an original, and all taken together, constitute one Agreement. 

14

 

        12.8    Survival.    All covenants, representations and warranties
made in this Agreement continue in full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and any other obligations which,
by their terms, are to survive the termination of this Agreement) have been satisfied. The obligation of Borrower in Section 12.2 to indemnify Bank shall survive until the statute of
limitations with respect to such claim or cause of action shall have run. 

        12.9    Confidentiality.    In handling any financial statements or
other confidential information of Borrower, Bank shall exercise the same degree of care that it exercises for its own proprietary information, but disclosure of information may be made: (a) to
Bank's Subsidiaries or Affiliates; (b) to prospective transferees or purchasers of any interest in the Credit Extensions, subject to Section 12.1 hereof (provided, however, Bank shall
use commercially reasonable efforts to obtain such prospective transferee's or purchaser's agreement to the terms of this provision); (c) as required by law, regulation, subpoena, or other
order; (d) to Bank's regulators or as otherwise required in connection with Bank's
examination or audit; and (e) as Bank considers appropriate in exercising remedies under this Agreement. Confidential information does not include information that either: (i) is in the
public domain or in Bank's possession when disclosed to Bank, or becomes part of the public domain after disclosure to Bank; or (ii) is disclosed to Bank by a third party, if Bank does not know
that the third party is prohibited from disclosing the information. 

        12.10    Right of Set Off.    Borrower hereby grants to Bank, a right
of set off as security for all Obligations to Bank, whether now existing or hereafter arising upon and against all deposits, credits, collateral and property, now or hereafter in the possession,
custody, safekeeping or control of Bank or any entity under the control of Bank (including a Bank subsidiary) or in transit to any of them. At any time after the occurrence and during the continuance
of an Event of Default, without demand or notice, Bank may set off the same or any part thereof and apply the same to any liability or obligation of Borrower even though unmatured and regardless of
the adequacy of any other collateral securing the Obligations. ANY AND ALL RIGHTS TO REQUIRE BANK TO EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT TO ANY COLLATERAL WHICH SECURES THE OBLIGATIONS, PRIOR
TO EXERCISING ITS RIGHT OF SETOFF WITH RESPECT TO SUCH DEPOSITS, CREDITS OR OTHER PROPERTY OF BORROWER ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY WAIVED. 

        13    DEFINITIONS    

        13.1    Definitions.    As used in this Agreement, the following terms
have the following meanings: 

        "Account Debtor" is any "account debtor" as defined in the Code with such additions to such term as may hereafter be made. 

        "Affiliate" of any Person is a Person that owns or controls directly or indirectly the Person, any Person that controls or is controlled
by or is under common control with the Person, and each of that Person's senior executive officers, directors, partners and, for any Person that is a limited liability company, that Person's managers
and members. 

        "Agreement" is defined in the preamble hereof. 

        "Bank" is defined in the preamble hereof. 

        "Bank Expenses" are all audit fees and expenses, costs, and expenses (including reasonable attorneys' fees and expenses) for preparing,
negotiating, administering, defending and enforcing the Loan
Documents (including, without limitation, those incurred in connection with appeals or Insolvency Proceedings) or otherwise incurred by Bank with respect to Borrower. 

        "Borrower" is defined in the preamble hereof. 

15

 

        "Borrower's Books" are all Borrower's books and records including ledgers, federal and state tax returns, records regarding Borrower's
assets or liabilities, the Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information. 

        "Borrowing Resolutions" are, with respect to any Person, those resolutions adopted by such Person's Board of Directors and delivered by
such Person to Bank approving the Loan Documents to which such Person is a party and the transactions contemplated thereby, together with a certificate executed by its secretary on behalf of such
Person certifying that (a) such Person has the authority to execute, deliver, and perform its obligations under each of the Loan Documents to which it is a party, (b) that attached as
Exhibit A to such certificate is a true, correct, and complete copy of the resolutions then in full force and effect authorizing and ratifying the execution, delivery, and performance by such
Person of the Loan Documents to which it is a party, (c) the name(s) of the Person(s) authorized to execute the Loan Documents on behalf of such Person, together with a sample of the true
signature(s) of such Person(s), and (d) that Bank may conclusively rely on such certificate unless and until such Person shall have delivered to Bank a further certificate canceling or amending
such prior certificate. 

        "Business Day" is any day that is not a Saturday, Sunday or a day on which Bank is closed. 

        "Cash Equivalents" means (a) marketable direct obligations issued or unconditionally guaranteed by the United States or any agency
or any State thereof having maturities of not more than one (1) year from the date of acquisition; (b) commercial paper maturing no more than one (1) year after its creation and
having the highest rating from either Standard & Poor's Ratings Group or Moody's Investors Service, Inc., (c) Bank's certificates of deposit issued maturing no more than one
(1) year after issue, and (d) money market funds at least ninety-five percent (95%) of the assets of which constitute Cash Equivalents of the kinds described in clauses
(a) through (c) of this definition. 

        "Claims" is defined in Section 12.2. 

        "Code" is the Uniform Commercial Code, as the same may, from time to time, be enacted and in effect in the Commonwealth of Massachusetts;
provided, that, to the extent that the Code is used to
define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such term contained in Article or Division 9 shall
govern; provided further, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority of, or remedies with respect to, Bank's Lien on any
Collateral is governed by the Uniform Commercial Code in effect in a jurisdiction other than the Commonwealth of Massachusetts, the term "Code" shall
mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely for purposes on the provisions thereof relating to such attachment, perfection, priority, or remedies and
for purposes of definitions relating to such provisions. 

        "Collateral" is any and all properties, rights and assets of Borrower described on  Exhibit A. 

        "Communication" is defined in Section 10. 

        "Contingent Obligation" is, for any Person, any direct or indirect liability, contingent or not, of that Person for (a) any
indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation directly or indirectly guaranteed, endorsed, co-made, discounted or sold with recourse
by that Person, or for which that Person is directly or indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all obligations from
any interest rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates,
currency exchange rates or commodity prices; but "Contingent Obligation" does not include endorsements in the ordinary course of business. The amount of a Contingent Obligation is the stated or
determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum 

16

 

reasonably
anticipated liability for it determined by the Person in good faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement. 

        "Credit Extension" is any Equipment Advance under this Agreement. 

        "Default" means any event which with notice or passage of time or both, would constitute an Event of Default. 

        "Default Rate" is defined in Section 2.2(b). 

        "Deposit Account" is any "deposit account" as defined in the Code with such additions to such term as may hereafter be made. 

        "Designated Deposit Account" is Borrower's Deposit Account, account
number                        , maintained with Bank. 

        "Dollars," "dollars" and
"$" each mean lawful money of the United States. 

        "Draw Period" is the period of time from the Effective Date through the earliest to occur of (a) March 31, 2007, or
(b) an Event of Default. 

        "Effective Date" is defined in the preamble of this Agreement. 

        "Eligible Equipment" is (a) new and/or used general purpose computer equipment, office equipment, test and laboratory equipment,
and furnishings, subject to the limitations set forth herein, and (b) Other Equipment that complies with all of Borrower's representations and warranties to Bank and which is acceptable to Bank
in all respects and in which Bank has a first priority Lien. 

        "Equipment" is all "equipment" as defined in the Code with such additions to such term as may hereafter be made, and includes without
limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing. 

        "Equipment Advance" is defined in Section 2.1.1. 

        "Equipment Line" is an Equipment Advance or Equipment Advances in an aggregate amount of up to One Million Five Hundred Thousand Dollars
($1,500,000.00) outstanding at any time. 

        "Equipment Maturity Date" is March 1, 2010. 

        "ERISA" is the Employment Retirement Income Security Act of 1974, and its regulations. 

        "Event of Default" is defined in Section 8. 

        "Event of Loss" is defined in Section 2.1.1(d). 

        "Final Payment" is a payment (in addition to and not a substitution for the regular monthly payments of principal plus accrued interest)
due on the earlier of (a) the Equipment Maturity Date, or (b) the acceleration of the Equipment Line following an Event of Default, equal to the Loan Amount multiplied by the Final
Payment Percentage; provided, however, that for purposes of Section 2.1.1(d), the amount of the Final Payment shall be equal to the amount of the Equipment Advance relating to the Financed
Equipment subject to the Event of Loss multiplied by the Final Payment Percentage. 

        "Final Payment Percentage" is, for each Equipment Advance, five percent (5.0%). 

        "Financed Equipment" is all present and future Eligible Equipment in which Borrower has any interest, the purchase of which is financed by
an Equipment Advance. 

        "Funding Date" is any date on which a Credit Extension is made to or on account of Borrower which shall be a Business Day. 

17

 

        "GAAP" is generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the
American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other Person as may be approved by
a significant segment of the accounting profession, which are applicable to the circumstances as of the date of determination. 

        "Indebtedness" is (a) indebtedness for borrowed money or the deferred price of property or services, such as reimbursement and
other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations, and
(d) Contingent Obligations. 

        "Initial Equipment Advance" is defined in Section 2.1.1. 

        "Insolvency Proceeding" is any proceeding by or against any Person under the United States Bankruptcy Code, or any other bankruptcy or
insolvency law, including assignments for the benefit of
creditors, compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 

        "Investment" is any beneficial ownership interest in any Person (including stock, partnership interest or other securities), and any loan,
advance or capital contribution to any Person. 

        "Key Person" means, Chief Executive Officer, Chief Operating Officer, and/or Head of Development, who are currently Christoph Westphal,
Garen Bohlin, and Peter Elliott, respectively. 

        "Lien" is a mortgage, lien, deed of trust, charge, pledge, security interest or other encumbrance. 

        "Loan Amount" is the original aggregate principal amount of the Equipment Advances. 

        "Loan Documents" are, collectively, this Agreement, the Warrant, the Perfection Certificate, any note, or notes or guaranties executed by
Borrower, and any other present or future agreement between Borrower and Bank for the benefit of Bank in connection with this Agreement, all as amended, restated, or otherwise modified. 

        "Material Adverse Change" is (a) a material impairment in the perfection or priority of Bank's Lien in the Collateral or in the
value of such Collateral; (b) a material adverse change in the business, operations, or condition (financial or otherwise) of Borrower; or (c) a material impairment of the prospect of
repayment of any portion of the Obligations. 

        "Obligations" are Borrower's obligation to pay when due any debts, principal, interest, Bank Expenses and other amounts Borrower owes Bank
now or later, under this Agreement and the Loan Documents, including, without limitation, interest accruing after Insolvency Proceedings begin, and the performance of Borrower's duties under the Loan
Documents. 

        "Operating Documents" are, for any Person, such Person's formation documents, as certified with the Secretary of State of such Person's
state of formation on a date that is no earlier than 30 days prior to the Effective Date, and its bylaws in current form, each of the foregoing with all current amendments or modifications
thereto. 

        "Other Equipment" is leasehold improvements, transferable software licenses, and other soft costs approved by Bank, including taxes,
warranty charges, freight expenses and installation expenses. 

        "Payment/Advance Form" is that certain form attached hereto as Exhibit B. 

        "Payment Date" is the first calendar day of each calendar month. 

        "Perfection Certificate" is defined in Section 5.1. 

18

 

        "Permitted Indebtedness" is: 

        (a)   Borrower's
Indebtedness to Bank under this Agreement and the other Loan Documents; 

        (b)   Indebtedness
existing on the Effective Date and shown on the Perfection Certificate; 

        (c)   Subordinated
Debt; 

        (d)   unsecured
Indebtedness to trade creditors incurred in the ordinary course of business; 

        (e)   Indebtedness
incurred as a result of endorsing negotiable instruments received in the ordinary course of business; 

        (f)    Indebtedness
secured by Permitted Liens; 

        (g)   Indebtedness
pursuant to a certain credit facility by and between Borrower and Hercules Growth Technology Capital, Inc. up to a maximum principal amount of
Fifteen Million Dollars ($15,000,000.00); and 

        (h)   extensions,
refinancings, modifications, amendments and restatements of any items of Permitted Indebtedness (a) through (g) above, provided that the
principal amount thereof is not increased or the terms thereof are not modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be. 

        "Permitted Investments" are: 

        (a)   Investments
shown on the Perfection Certificate and existing on the Effective Date; 

        (b)   joint
ventures or strategic alliances in the ordinary course of Borrower's business and investments consisting of the licensing of technology, the development of
technology or the providing of technical support; 

        (c)   Investments
made pursuant to Borrower's Investment Policy dated as of                        , and attached hereto as  Exhibit C, as amended from time to time, provided that any amendments expanding the definition of Permitted Investments shall be approved by Bank
in writing; 

        (d)   other
Investments not otherwise permitted by Section 7.7 not exceeding Two Hundred Thousand Dollars ($200,000.00) in the aggregate outstanding at any time; and 

        (e)   Cash
Equivalents. 

        "Permitted Liens" are: 

        (a)   Liens
existing on the Effective Date and shown on the Perfection Certificate or arising under this Agreement and the other Loan Documents; 

        (b)   Liens
for taxes, fees, assessments or other government charges or levies, either not delinquent or being contested in good faith and for which Borrower maintains
adequate reserves on its Books, if they have no priority over any of Bank's Liens; 

        (c)   (i) leasehold
improvements, or (ii) purchase money Liens and capital leases (x) on Equipment acquired or held by Borrower incurred for financing the
acquisition of the Equipment securing no more than Two Million Dollars ($2,000,000.00) in the aggregate amount outstanding, or (y) existing on Equipment when acquired,  if the Lien is confined to
the property and improvements and the proceeds of the Equipment; 

        (d)   Liens
in favor of Hecules Growth Technology Capital, Inc. securing the Permitted Indebtedness; and 

        (e)   Liens
incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (d),  but any extension, renewal or replacement Lien must be limited to the

19

 

property
encumbered by the existing Lien and the principal amount of the indebtedness may not increase. 

        "Person" is any individual, sole proprietorship, partnership, limited liability company, joint venture, company, trust, unincorporated
organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or government agency. 

        "Prime Rate" is Bank's most recently announced "prime rate," even if it is not Bank's lowest rate. 

        "Registered Organization" is any "registered organization" as defined in the Code with such additions to such term as may hereafter be
made. 

        "Responsible Officer" is any of the Chief Executive Officer, President, Chief Financial Officer and Controller of Borrower. 

        "Subordinated Debt" is indebtedness incurred by Borrower subordinated to all of Borrower's now or hereafter indebtedness to Bank (pursuant
to a subordination, intercreditor, or other similar agreement in form and substance satisfactory to Bank entered into between Bank and the other creditor), on terms acceptable to Bank. 

        "Subsidiary" means, with respect to any Person, any Person of which more than 50% of the voting stock or other equity interests is owned
or controlled, directly or indirectly, by such Person or one or more Affiliates of such Person. 

        "Transfer" is defined in Section 7.1. 

        "Warrant" is that certain Warrant to Purchase Stock dated June 23, 2006, executed by Borrower in favor of Bank. 

Signature
page follows. 

20

        IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as a sealed instrument under the laws of the Commonwealth
of Massachusetts as of the Effective Date. 

	BORROWER:	 	 
	

SIRTRIS PHARMACEUTICALS, INC.	
 	

 
	

By	

/s/  GAREN BOHLIN      
	
 	

 
	Name:	Garen Bohlin
	 	 
	Title:	Chief Operating Officer
	 	 
	

BANK:	
 	

 
	

SILICON VALLEY BANK	
 	

 
	By	/s/  BERNADETTE M. MICHAUD      
	 	 
	Name:	Bernadette M. Michaud
	 	 
	Title:	Vice President
	 	 

[Signature
page to Loan and Security Agreement] 

 
EXHIBIT A  

        The
Collateral consists of all of Borrower's right, title and interest in and to the following: 

        1.     Each
item of equipment, or personal property financed with a "Equipment Advance" pursuant to that certain Loan and Security Agreement, dated as of June 23, 2006
(the "Loan Agreement"), by and between Borrower and Bank, including, without limitation, the property described in Annex A hereto, whether now owned or hereafter acquired, together with all
substitutions, renewals or replacements of and additions, improvements, and accessions to any and all of the foregoing, and all proceeds from sales, renewals, releases or other dispositions thereof. 

        2.     All
Borrower's Books relating to the equipment, or personal property referred to in paragraph 1. 

1

 
Annex A to Exhibit A  

        The Financed Equipment being financed with the Equipment Advance is listed below. Upon the funding of such Equipment Advance, this schedule automatically shall be
deemed to be a part of the Collateral. 

	Description of Equipment
 
	 	Make
	 	Model
	 	Serial #
	 	Invoice#

	    	 	    	 	    	 	 	 	 
	    	 	    	 	    	 	 	 	 
	    	 	    	 	    	 	 	 	 
	    	 	    	 	    	 	 	 	 
	    	 	    	 	    	 	 	 	 

2

   EXHIBIT B  

 Loan Payment/Advance Request Form  

	Fax To:	 	Date:
                                    

LOAN PAYMENT:  

Sirtris Pharmaceuticals, Inc.  

	From Account #	 	 	To Account #	 
	 	
 (Deposit Account #)	 	 	
 (Loan Account #)
	

Principal $	

 	
 	

and/or Interest $	

 
	 	
	 	 	

	    	 	 	 	 
	Authorized Signature:	 	 	                   Phone Number:	 
	 	
	 	 	

	Print Name/Title:	 	 	 	 
	 	
	 	 	 

LOAN ADVANCE:  

Complete
Outgoing Wire Request section below if all or a portion of the funds from this loan advance are for an outgoing wire. 

	From Account #	 	 	To Account #	 
	 	
 (Loan Account #)	 	 	
 (Deposit Account #)

	Amount of Advance $	 	 	 	 
	 	
	 	 	 

All
Borrower's representations and warranties in the Loan and Security Agreement are true, correct and complete in all material respects on the date of the request for an advance; provided, however,
that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that
those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such
date:

	    	 	 	 	 
	Authorized Signature:	 	 	Phone Number:	 
	 	
	 	 	

	

Print Name/Title:	

 	
 	

 	

 
	 	
	 	 	 

OUTGOING WIRE REQUEST:
  Complete only if all or a portion of funds from the loan advance above is to be wired.

Deadline for same day processing is noon, E.S.T. 

	

 	

 	
 	

 	

 
	Beneficiary Name:	 	 	Amount of Wire: $	 
	 	
	 	 	

	

Beneficiary Bank:	

 	
 	

Account Number:	

 
	 	
	 	 	

	City and State:	 	 	 	 
	 	
	 	 	 

	

 	

 	
 	

 	

 
	Beneficiary Bank Transit (ABA) #:	 	 	Beneficiary Bank Code (Swift, Sort, Chip, etc.):
 (For International Wire Only)	 
	 	
	 	 	

	

Intermediary Bank:	

 	
 	

Transit (ABA) #:	

 
	 	
	 	 	

	For Further Credit to:	 	 	 	 
	 	

	    	 	 	 	 
	Special Instruction:	 	 	 	 
	 	

By signing below, I (we) acknowledge and agree that my (our) funds transfer request shall be processed in accordance with and subject to the terms and conditions set forth in
the agreements(s) covering funds transfer service(s), which agreements(s) were previously received and executed by me
(us).

	Authorized Signature:	 	 	2nd Signature (if required):	 
	 	
	 	 	

	Print Name/Title:	 	 	Print Name/Title:	 
	 	
	 	 	

	Telephone #:	 	 	Telephone #:	 
	 	
	 	 	

1

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Exhibit 10.7QuickLinks
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Exhibit 10.8    
    

THIS
WARRANT AND THE UNDERLYING SHARES OF SERIES B PREFERRED STOCK ISSUABLE UPON ITS EXERCISE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR ANY STATE SECURITIES
LAWS, AND NO SALE OR TRANSFER THEREOF MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT OR AN OPINION OF COUNSEL FOR THE HOLDER, SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATION IS NOT
REQUIRED UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. 

No. W-[    ]

SIRTRIS
PHARMACEUTICALS, INC. 

Series B
Preferred Stock Purchase

Warrant August 1, 2005 

        For
value received, Sirtris Pharmaceuticals, Inc., a Delaware corporation (the "Company"), hereby grants ARE-770/784/790 Memorial Drive, LLC, a Delaware limited
liability company (the "Investor"), subject to the terms set forth below, the right to purchase from the Company at any time or from time to time before the earlier of 5:00 P.M., Boston time,
on August 1, 2015, and the termination of the Agreement (as defined below) due to a breach by the Investor, sixty-two thousand five hundred (62,500) fully paid and nonassessable
shares of Series B Preferred Stock, $0.001 par value per share, of the Company (the "Series B Preferred Stock"), at a purchase price per share of $0.80 (such purchase price per share as
adjusted from time to time as herein provided is referred to herein as the "Purchase Price"). The number and character of such shares of Series B Preferred Stock and the Purchase Price are
subject to adjustment as provided herein. 

        This
Warrant evidences the right to purchase shares of Series B Preferred Stock of the Company, issued pursuant to a certain Lease Agreement (the "Agreement"), dated as of
August 1, 2005, between the Company and the Investor, a copy of which is on file at the principal office of the Company. 

        As
used herein the following terms, unless the context otherwise requires, have the following respective meanings: 

        (a)   The
term "Common Stock" includes the Company's Common Stock, $0.001 par value per share. 

        (b)   The
term "Company" shall includes Sirtris Pharmaceuticals, Inc. and any corporation which shall succeed or assume the obligations of the Company hereunder. 

        1.    Exercise of Warrant.    

        1.1.    Full Cash Exercise.    This Warrant may be exercised in full by the holder hereof by surrender of this
Warrant, with the form of subscription at the end hereof duly executed by such holder, to the Company at its principal office, accompanied by payment, in cash or by certified or official bank check
payable to the order of the Company, in the amount obtained by multiplying the number of shares of Series B Preferred Stock for which this Warrant is then exercisable by the Purchase Price then
in effect. 

        1.2.    Partial Exercise.    This Warrant may be exercised in part by surrender of this Warrant in the manner and at
the place provided in Section 1.1 except that the amount payable by the holder on such partial cash exercise shall be the amount obtained by multiplying (a) the number of shares of
Series B Preferred Stock designated by the holder in the subscription at the end hereof by (b) the Purchase Price then in effect. On any such partial exercise, the Company at its expense
will forthwith issue and deliver to the holder hereof a new Warrant or Warrants of like tenor in the name of the holder hereof, calling in the aggregate on the face or faces thereof for the number of
shares of Series B Preferred Stock for which such Warrant or Warrants may still be exercised. 

 

        1.3.    Cashless Exercise.    In addition to and without limiting the rights of the Holder hereof under the terms
hereof, at the Holder's option this Warrant may be exercised in whole or in part at any time or from time to time prior to its expiration for a number of shares of Series B Preferred Stock
having an aggregate fair market value on the date of such exercise equal to the difference between (a) the fair market value of the number of shares of Common Stock into which such shares of
Series B Preferred
Stock are convertible on the date of exercise and (b) the aggregate Warrant Price for such shares in effect at such time. 

        The
"fair market value" of shares of Common Stock shall be calculated on the basis of (a) if the Common Stock is then traded on a securities exchange, the average of the closing
prices of the Common Stock on such exchange over the 20 trading day period ending three (3) trading days prior to the date of exercise, (b) if the Common Stock is then regularly traded
over-the-counter, the average of the sale prices or, if sale prices for the Common Stock are not regularly and publicly reported, then the closing bid of the Common Stock over
the 20 trading day period ending three (3) trading days prior to the date of exercise, or (c) if there is no active public market for the Common Stock, the fair market value thereof
shall be determined in good faith by the Company's Board of Directors. If the Holder of this Warrant exercises this Warrant contingent upon the closing of a public offering, the "fair market value" of
a share of Common Stock on the date of exercise shall be equal to the initial price to the public specified in the final prospectus with respect to such public offering. The following formula
illustrates how many shares would be issued upon exercise of this Warrant pursuant to the "cashless exercise" provisions of this Section 1.5: 

	 	 	Let	 	FMV	 	=	 	Fair market value per share of Common Stock at date of exercise.
	

 	
 	

 	
 	

PSP	
 	

=	
 	

Per share Warrant Price at date of exercise.
	

 	
 	

 	
 	

N	
 	

=	
 	

Number of shares of Series B Preferred Stock desired to be exercised multiplied by the conversion rate of such shares.
	

 	
 	

 	
 	

X	
 	

=	
 	

Number of shares of Series B Preferred Stock issued upon exercise.
	

 	
 	

 	
 	

X	
 	

=	
 	

(FMV)(N)-(PSP)(N)

            FMV

No
payment of any cash or other consideration to the Company shall be required from the holder of this Warrant in connection with any exercise of this Warrant pursuant to this Section 1.5. Such
exercise shall be effective upon the date of receipt by the Company of this Warrant surrendered for cancellation and a written request from the holder hereof that the exercise pursuant to this section
be made, or at such later date as may be specified in such request. 

        1.4.    Securities Laws.    The Investor acknowledges and agrees that this warrant may only be exercised by Investor
if the Company is satisfied, based on among other things representations by the Investor, that such exercise will not result in any violation by the Company of applicable securities laws. 

        2.    Delivery of Stock Certificates, etc. on Exercise.    As soon as practicable after each exercise of this Warrant
in full or in part, the Company at its expense will cause to be issued in the name of and delivered to the holder hereof, or as such holder (upon payment by such holder of any applicable transfer
taxes and, if requested by the Company, demonstration by such holder of compliance with applicable securities laws) may direct, a certificate or certificates for the number of fully paid and
nonassessable shares of Series B Preferred Stock to which such holder shall be entitled on such exercise or such other property or securities to which Investor may be entitled to receive upon
exercise. 

2

 

        3.    Adjustment for Reorganization, Consolidation, Merger, Recapitalization, etc.    

        3.1.    Reorganization.    In case at any time or from time to time, the Company shall (a) effect a
reorganization, (b) consolidate with or merge into any other person, or (c) effect a recapitalization, then, in each such case, the holder of this Warrant, on the exercise hereof as
provided in Section 1 at any time after the consummation of such reorganization, consolidation, merger or recapitalization as the case may be, shall receive, in lieu of the Series B
Preferred Stock issuable on such exercise prior to such consummation or such effective date, the stock and other securities and property (including cash) to which such holder would have been entitled
upon such consummation, if such holder had so exercised this Warrant immediately prior thereto, all subject to further adjustment thereafter as provided in Section 4. 

        3.2.    Continuation of Terms.    Upon any reorganization, consolidation, merger or recapitalization, referred to in
this Section 3, this Warrant shall continue in full force and effect and the terms hereof shall be applicable to the shares of stock and other securities and property receivable on the exercise
of this Warrant after the consummation of such reorganization, consolidation, merger or recapitalization, as the case may be, and shall be binding upon the issuer of any such stock or other
securities, including, in the case of any such transfer, the person acquiring all or substantially all of the properties or assets of the Company. 

        3.3.    Conversion.    If all shares of Series B Preferred Stock are converted into Common Stock, then the
holder of this Warrant, on the exercise hereof as provided in Section 1 at any time after such conversion, shall receive, in lieu of the Series B Preferred Stock issuable upon such
exercise, the number of shares of Common Stock to which a holder of the number of shares of Series B Preferred Stock issuable upon exercise of this Warrant would have been entitled if such
shares of Series B Preferred Stock had been issued and held by the holder on the date the Series B Preferred Stock converted into Common Stock. 

        4.    Adjustment for Extraordinary Events.    In the event that the Company shall (i) issue additional shares
of its Series B Preferred Stock as a dividend or other distribution on outstanding Series B Preferred Stock, (ii) subdivide its outstanding shares of Series B Preferred
Stock, or (iii) combine its outstanding shares of the Series B Preferred Stock into a smaller number of shares of Series B Preferred Stock, then, in each such event, the Purchase
Price shall, simultaneously with the happening of such event, be adjusted by multiplying the then Purchase Price by a fraction, the numerator of which shall be the number of shares of Series B
Preferred Stock outstanding immediately prior to such event and the denominator of which shall be the number of shares of Series B Preferred Stock outstanding immediately after such event, and
the product so obtained shall thereafter be the Purchase Price then in effect. The Purchase Price, as so adjusted, shall be readjusted in the same manner upon the happening of any successive event or
events described herein in this Section 4. The holder of this Warrant shall thereafter, on the exercise hereof as provided in Section 1, be entitled to receive that number of shares of
Series B Preferred Stock determined by multiplying the number of shares of Series B Preferred Stock which would otherwise (but for the provisions of this Section 4) be issuable on
such exercise by a fraction of which (i) the numerator is the Purchase Price which would otherwise (but for the provisions of this Section 4) be in effect, and (ii) the
denominator is the Purchase Price in effect on the date of such exercise. 

        5.    Notices of Record Date, etc.    In the event of 

        (a)   any
taking by the Company of a record of the holders of any class or securities for the purpose of determining the holders thereof who are entitled to receive any
dividend or other distribution, or any right to subscribe for, purchase or otherwise acquire any shares of stock of any class or any other securities or property, or to receive any other right, 

3

 

        (b)   any
capital reorganization of the Company, any reclassification or recapitalization of the capital stock of the Company or any transfer of all or substantially all the
assets of the Company to or consolidation or merger of the Company with or into any other person, or 

        (c)   any
voluntary or involuntary dissolution, liquidation or winding-up of the Company, 

then
and in each such event the Company will mail or cause to be mailed to each registered holder of a Warrant a notice specifying (i) the date on which any such record is to be taken for the
purpose of such dividend, distribution or right, and stating the amount and character of such dividend, distribution or right, and (ii) the date on which any such reorganization,
reclassification, recapitalization, transfer, consolidation, merger, dissolution, liquidation or winding-up is to take place, and the time, if any is to be fixed, as of which the holders
of record of Capital Stock shall be entitled to exchange their shares of Capital Stock for securities or other property deliverable on such reorganization, reclassification, recapitalization,
transfer, consolidation, merger, dissolution, liquidation or winding-up. 

        6.    Company's Representations.    

        (a)   The
Company will at all times that this Warrant is exercisable for Series B Preferred Stock reserve and keep available, solely for issuance and delivery on the
exercise of the Warrant, (i) all shares of Series B Preferred Stock from time to time issuable on the exercise of the Warrant, and (ii) all shares of Common Stock issuable upon
conversion of such shares of Series B Preferred Stock. 

        (b)   The
Company has full power and authority to enter into this Warrant. This Warrant has been duly authorized, executed and delivered by the Company and constitutes its
valid and legally binding obligation, enforceable in accordance with its terms. 

        (c)    Valid Issuance.    This Warrant, when issued and delivered in accordance with the terms hereof will be duly
authorized and validly issued, the Series B Preferred Stock issuable upon the exercise hereof, and the Common Stock issuable upon conversion thereof, when issued pursuant to the terms hereof,
and upon payment of the exercise price, shall, upon such issuance, be duly authorized, validly issued, fully paid and nonassessable. 

        7.    Replacement of Warrants.    On receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of any Warrant and, in the case of any such loss, theft or destruction of any Warrant, on delivery of an indemnity agreement or security reasonably satisfactory in form and
amount to the Company or, in the case of any such mutilation, on surrender and cancellation of such warrant, the Company at its expense will execute and deliver, in lieu thereof, a new Warrant of like
tenor. 

        8.    Registered Holder.    The registered holder of this Warrant shall be deemed the owner hereof and of the Warrants
evidenced hereby for all purposes. The registered holder of this Warrant shall not be entitled by virtue of ownership of this Warrant to any rights whatsoever as a shareholder of the Company. 

        9.    Transfer.    Neither this Warrant, any shares of Series B Preferred Stock issued upon exercise hereof nor
any Common Stock issued upon conversion of the Series B Preferred Stock may be transferred or succeeded to by any person other than an affiliate of the Investor without the prior written
consent of the Company, which consent shall not be unreasonably withheld. Neither this Warrant, any shares of Series B Preferred Stock issued upon exercise hereof nor any Common Stock issued
upon conversion of the Series B Preferred Stock may be sold, transferred, pledged, hypothecated or otherwise disposed of unless and until: (i) there is then in effect a registration
statement under the Securities Act of 1933, as amended (the "Securities Act"), covering such proposed disposition and such disposition is made in accordance with such registration statement and all
applicable state securities laws; or (ii) (A) the transferor shall have notified the Company of the proposed disposition and shall 

4

 

have
furnished the Company with a statement of the circumstances surrounding the proposed disposition, and (B) if reasonably requested by the Company, such transferor shall have furnished the
Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such securities under the Securities Act and that all requisite
action has been or will, on a timely basis, be taken under any applicable state securities laws in connection with such disposition; and (iii) the proposed transferee shall have agreed in
writing to be bound by the terms and provisions of this Section 9. 

        10.    Investor Representations.    As a condition to its acceptance of this Warrant, Investor represents and warrants
as follows: 

        (a)   Investor
is acquiring this Warrant and the Series B Preferred Stock and the shares of Common Stock issuable upon conversion of the Series B Preferred Stock
(collectively, the "Securities") for its own account for investment and not with a view toward distribution in a manner which would violate the Securities Act of 1933. 

        (b)   Investor,
by reason of the business and financial experience of its management, has the capacity to protect its own interests in connection with the transactions
contemplated by this Agreement. Investor is able to bear the economic risk of an investment in the Securities and is able to sustain a loss of all of its investment in the Securities without economic
hardship if such a loss should occur. 

        (c)   Investor
is an "accredited investor" as that term is defined in Regulation D promulgated under the Securities Act. 

        11.    Notices, etc.    All notices and other communications from the Company to the holder of this Warrant shall be
mailed by first class registered or certified mail, postage prepaid, at such address as may have been furnished to the Company in writing by such holder or, until any such holder furnishes to the
Company an address, then to, and at the address of, the last holder of this Warrant who has so furnished an address to the Company. 

        12.    Registration Rights.    In connection with this Warrant, the Investor shall have the registration rights set
forth in that certain Second Amended and Restated Registration Rights Agreement dated February 25, 2005, as amended by Amendment No. 1 to Second Amended and Restated Registration Rights
Agreement dated as of August 1, 2005 (as amended from time to time, the "Rights Agreement"). The Company shall not amend or delete Section 1(f)(3) of the Rights Agreement or
Section 1(m) of the Rights Agreement without the written consent of the Investor. Additionally, the Company shall not amend the Rights Agreement in a manner that materially and adversely
affects the rights and obligations of the Investor under the Rights Agreement unless other Holders (as defined under the Rights Agreement) are similarly affected. 

        13.    Miscellaneous.    This Warrant and any term hereof may be changed, waived, discharged or terminated only by an
instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. This Warrant shall be construed and enforced in accordance with and
governed by the laws of The Commonwealth of Massachusetts. The headings in this Warrant are for purposes of reference only, and shall not limit or otherwise affect any of the terms hereof. This
Warrant is being executed as an instrument under seal. The invalidity or unenforceability of any provision hereof shall in no way affect the validity or enforceability of any other provision. 

[Remainder
of page intentionally left blank.] 

5

 

	 	 	SIRTRIS PHARMACEUTICALS, INC.
	

 	
 	

By:	

/s/  ROBERT CRANE      
 Name: Robert Crane

Title: Chief Financial Officer

ACCEPTED
AND AGREED 

ARE-770/784/790 MEMORIAL DRIVE, LLC,

a Delaware limited liability company 

	By:
	ALEXANDRIA REAL ESTATE EQUITIES, L.P.,

a Delaware limited partnership,

managing member

	By:
	ARE-QRS Corp.,

a Maryland corporation, general partner 

	

By:	

/s/  DEAN A. SHIGENAGA      
	

 
	Name:	Dean A. Shigenaga
	 
	Title:	Vice President, Chief Financial Officer
	 

Dated:
August 1, 2005 

6

 
FORM OF SUBSCRIPTION 

(To
be signed only on exercise of Warrant) 

TO:
Sirtris Pharmaceuticals, Inc. 

The
undersigned, the holder of the within Warrant, hereby irrevocably elects to exercise this Warrant for, and to purchase thereunder.......... shares of Series B Preferred Stock of Sirtris
Pharmaceuticals, Inc. and herewith makes payment of $........ therefor, and requests that the certificates for such shares be issued in the name of, and delivered to............... whose
address is.................................................................. 

	Dated:	 	
 (Signature must conform to name of holder as specified on the face of the Warrant)
	

 	
 	

 (Address)

7

QuickLinks

Exhibit 10.8

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