Document:

EX-10.2

 Exhibit 10.2 

TRANSITION AND SEPARATION AGREEMENT 

This Transition and Separation Agreement (the “Agreement”) by and between Dominique Charmot, Ph.D.
(“Executive”) and Ardelyx, Inc. (the “Company”), is made effective as of the date Executive signs this Agreement (the “Effective Date”) with reference to the following facts: 

A. Executive is the Company’s Chief Scientific Officer and a member of the Company’s Board of Directors (the
“Board”). 
 B. Executive and the Company entered into a Change in Control Severance Agreement dated June 14, 2014
(the “Severance Agreement”) pursuant to which the Executive has certain severance rights for a covered termination and certain continuing obligations to the Company. 

C. Executive’s employment with the Company, status as an officer and employee of the Company, and membership on the Company’s Board
and any committees thereof will end effective upon the Resignation Date (as defined below). 
 D. Executive and the Company want to end
their relationship amicably and also to establish the obligations of the parties including, without limitation, all amounts due and owing to the Executive. 

NOW, THEREFORE, in consideration of the mutual covenants and agreements hereinafter set forth, the parties agree as follows: 

1. Resignation Date. Executive acknowledges and agrees that his status as an officer and employee of the Company and his
membership on the Board and any committees thereof will end effective as of December 23, 2014 (the “Resignation Date”). Executive hereby agrees to execute such further document(s) as shall be determined by the Company as
necessary or desirable to give effect to the termination of Executive’s status as an officer of the Company and member of the Board; provided that such documents shall not be inconsistent with any of the terms of this Agreement. From the
Effective Date through the Resignation Date, the Executive’s employment with the Company shall continue in effect, and Executive shall enjoy the same salary, benefits and other compensation terms as in effect on the Effective Date. 

2. Transition. During the period commencing on the Effective Date and ending on (a) the Resignation Date, or
(b) such earlier date as Executive resigns his employment or the Company terminates Executive’s employment for Cause (as defined in the Severance Agreement) Executive shall continue to be employed by the Company in the full-time position
of Chief Scientific Officer and to receive salary and benefits as in effect as of the Effective Date. All compensation paid to Executive pursuant to this Section 2 shall be subject to standard payroll deductions and withholding. 

3. Severance Payments and Benefits. The Company hereby agrees, subject to Executive delivering to the Company a General
Release of Claims substantially in the form attached hereto as Exhibit A (the “Release of Claims”) on the Resignation Date, Executive not revoking the Release of Claims within the seven (7)-day period following his execution
of the Release of Claims (the “Revocation Period”), and Executive’s performance of his continuing obligations pursuant to this Agreement and the Proprietary Information and Inventions Assignment Agreement entered into between
Executive and the Company, as of November 1, 2007 (the “Confidential Information Agreement”), to provide the payments and benefits set forth in this Section 3. 

 (a) Severance Payments. Subject to the continued effectiveness of this
Agreement and the Release of Claims as of such date, on the first business day following the Revocation Period, the Company shall make a lump sum payment to Executive equal to twelve (12) months’ of his then-current base salary but no
later than December 31, 2014 provided that the Revocation Period has lapsed by such date (the “Severance Payment”). The Severance Payment shall be subject to standard payroll deductions and withholding. 

(b) COBRA Reimbursement. Provided that Executive timely elects to receive continued healthcare coverage pursuant to the
Consolidated Omnibus Budget Reconciliation Act of 1985, as amended, or applicable state law (collectively referred to as “COBRA”), the Company will reimburse COBRA premiums paid by the Executive for the lesser of
(i) twenty-four (24) months, or (ii) the date upon which Executive is otherwise no longer eligible for COBRA continuation coverage. 

(c) Restricted Stock. Effective as of the day after the end of the Revocation Period, and provided that Executive has
not revoked this Agreement or the Release of Claims during the Revocation Period, all outstanding shares of Common Stock held by the Executive shall become fully vested, and the Company’s right of repurchase of such shares shall lapse, on such
date. 
 (d) Benefits. Executive understands and agrees that, notwithstanding his right to receive the Severance
Payment, Executive shall not be eligible to participate in or accrue benefits under any Company benefit plan for which status as an employee of the Company is a condition of such participation or accrual. To the extent that Executive was deemed
eligible to participate, as an employee, in any Company benefit plan, he hereby waives his participation. 
 4. Final
Paycheck; Payment of Accrued Wages and Expenses. 
 (a) Final Paycheck. On the Resignation Date, the Company will
pay Executive all accrued but unpaid base salary and all accrued and unused vacation or other paid time off earned through the Resignation Date, subject to standard payroll deductions and withholding. Executive is entitled to these payments
regardless of whether Executive executes this Agreement or a Release of Claims (as defined below). 
 (b) Annual
Bonus. Subject to the continued effectiveness of this Agreement and the Release of Claims as of such date, on the first business day following the Revocation Period, the Company shall pay the Executive his annual bonus for 2014 in a lump sum
payment in an amount equal to twenty-five percent (25%) of his then current base salary but no later than December 31, 2014 provided that the Revocation Period has lapsed by such date (the “Bonus Payment”). The Bonus
Payment shall be subject to standard payroll deductions and withholding. 
 (c) Business Expenses. The Company shall
reimburse Executive for all outstanding expenses incurred prior to the Resignation Date which are consistent with the Company’s policies in effect from time to time with respect to travel and other business expenses, subject to the
Company’s requirements with respect to reporting and documenting such expenses, including, without limitation, expenses incurred pursuant to Executive’s services as a director of any of the Company’s subsidiaries. Executive is
entitled to these payments regardless of whether Executive executes this Agreement or a Release of Claims (as defined below). 

  
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 5. Full Payment. Executive acknowledges that the payment and arrangements
herein shall constitute full and complete satisfaction of any and all amounts properly due and owing to Executive as a result of his employment with the Company and the termination thereof. Executive further acknowledges that, other than the
Confidential Information Agreement and the agreements under which Executive acquired his shares of the Company’s Common Stock (the “Stock Agreements”), this Agreement shall supersede each agreement entered into between
Executive and the Company regarding Executive’s employment, including, without limitation, the Severance Agreement and any offer letter, or employment agreement and each such agreement other than the Stock Agreements and the Confidential
Information Agreement shall be deemed terminated and of no further effect as of the Resignation Date. 
 6.
Executive’s Release of the Company. Executive agrees that the consideration set forth in this Agreement represents settlement in full of all outstanding obligations owed to Executive by the Company and its current and former officers,
directors, employees, agents, investors, attorneys, affiliates, divisions, and subsidiaries, and predecessor and successor corporations and assigns (collectively, the “Releasees”). 

(a) Executive, on his own behalf and on behalf of his family members, heirs, executors, administrators, agents, and assigns,
hereby and forever releases the Releasees from, and agrees not to sue concerning, or in any manner to institute, prosecute, or pursue, any claim, complaint, charge, duty, obligation, or cause of action relating to any matters of any kind, whether
presently known or unknown, suspected or unsuspected, that Executive may possess against any of the Releasees arising from any omissions, acts, facts, or damages that have occurred up until and including the Effective Date of this Agreement,
including, without limitation: 
 (i) any and all claims relating to or arising from Executive’s employment
relationship with Company and the termination of that relationship; 
 (ii) any and all claims for wrongful discharge of
employment; termination in violation of public policy; discrimination; harassment; retaliation; breach of contract, both express and implied; breach of covenant of good faith and fair dealing, both express and implied; promissory estoppel; negligent
or intentional infliction of emotional distress; fraud; negligent or intentional misrepresentation; negligent or intentional interference with contract or prospective economic advantage; unfair business practices; defamation; libel; slander;
negligence; personal injury; assault; battery; invasion of privacy; false imprisonment; conversion; and disability benefits; 

(iii) any and all claims for violation of any federal, state, or municipal statute, including, but not limited to,
Title VII of the Civil Rights Act of 1964; the Civil Rights Act of 1991; the Rehabilitation Act of 1973; the Americans with Disabilities Act of 1990; the Equal Pay Act; the Fair Labor Standards Act, except as prohibited by law; the Fair Credit
Reporting Act; the Age Discrimination in Employment Act of 1967; the Older Workers Benefit Protection Act; the Employee Retirement Income Security Act of 1974; the Worker Adjustment and Retraining Notification Act; the Family and Medical Leave Act,
except as prohibited by law; the Sarbanes-Oxley Act of 2002, except as prohibited by law; the Uniformed Services 

  
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Employment and Reemployment Rights Act; the California Family Rights Act; the California Labor Code, except as prohibited by law; the California Workers’ Compensation Act, except as
prohibited by law; and the California Fair Employment and Housing Act; 
 (iv) any and all claims for violation of the
federal or any state constitution; 
 (v) any and all claims arising out of any other laws and regulations relating to
employment or employment discrimination; 
 (vi) any claim for any loss, cost, damage, or expense arising out of any dispute
over the non-withholding or other tax treatment of any of the proceeds received by Executive as a result of this Agreement; 

(vii) any and all claims for attorneys’ fees and costs. 

(b) Executive agrees that the release set forth in this section shall be and remain in effect in all respects as a complete
general release as to the matters released. This release does not extend to any obligations incurred under this Agreement or the Stock Agreements. This release does not release claims or rights that cannot be released as a matter of law, including,
but not limited to, claims under Division 3, Article 2 of the California Labor Code (which includes California Labor Code Section 2802 regarding indemnity for necessary expenditures or losses by Executive) any other indemnification, defense, or
hold-harmless rights Executive may have, and Executive’s right to bring to the attention of the Equal Employment Opportunity Commission or California Department of Fair Employment and Housing claims of discrimination, harassment or retaliation;
provided, however, that Executive does release his right to obtain damages for any such claims. This release does not release claims or rights that the Executive may have as a shareholder of the Company or for benefits under any benefit plan or to
participation in any such plan pursuant to the terms thereof or applicable law. 
 (c) Executive acknowledges that he has
been advised to consult with legal counsel and is familiar with the provisions of California Civil Code Section 1542, a statute that otherwise prohibits unknown claims, which provides as follows: 

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING
THE RELEASE, WHICH IF KNOWN BY HIM OR HER MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR. 
 Executive, being aware of
said code section, agrees to expressly waive any rights he may have thereunder, as well as under any other statute or common law principles of similar effect. 

  
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 7. Non-Disparagement; Transfer of Company Property. Executive further
agrees that: 
 (a) Non-Disparagement. Executive agrees that he shall not disparage, criticize or defame the Company,
its affiliates and their respective affiliates, directors, officers, agents, partners, stockholders, employees, products, services, technology or business, either publicly or privately. The Company agrees that it shall not, and it shall instruct its
officers and members of the Board to not, disparage, criticize or defame Executive, either publicly or privately. Nothing in this Section 7(a) shall have application to any evidence or testimony required by any court, arbitrator or government
agency. 
 (b) Transfer of Company Property. On or before the Resignation Date, Executive shall turn over to the
Company all files, memoranda, records, and other documents, and any other physical or personal property which are the property of the Company and which he has in his possession, custody or control at the Resignation Date. 

8. Confidentiality; Non-Solicitation. 

(a) Confidentiality. While Executive is employed by the Company, and thereafter, Executive shall not directly or
indirectly disclose or make available to any person, firm, corporation, association or other entity for any reason or purpose whatsoever, any Confidential Information (as defined below). On and after the Resignation Date, the Company’s Vice
Presidents and Senior Directors shall use all reasonable efforts not to provide any Company Confidential Information to Executive and the Company shall terminate all electronic and other access to the Company’s Confidential Information by
Executive. On the Resignation Date, all Confidential Information in Executive’s possession that is in written or other tangible form (together with all copies or duplicates thereof, including computer files) shall be returned to the Company and
shall not be retained by Executive or furnished to any third party, in any form except as provided herein; provided, however, that Executive shall not be obligated to treat as confidential, or return to the Company copies of any
Confidential Information that (i) was publicly known at the time of disclosure to Executive, (ii) becomes publicly known or available thereafter other than by any means in violation of this Agreement, the Confidential Information Agreement
or any other duty owed to the Company by any person or entity, or (iii) is lawfully disclosed to Executive by a third party. For purposes of this Agreement, the term “Confidential Information” shall mean information, technical data,
know-how or trade secrets disclosed to Executive or known by Executive as a consequence of or through his or her relationship with the Company, relating to research, products, developments, inventions, processes, techniques, chemical structures,
finances, business plans or regulatory strategies of the Company and its affiliates. In addition, for the avoidance of doubt, Executive shall continue to be subject to the Confidential Information Agreement. 

(b) Non-Solicitation. In addition to each Executive’s obligations under the Confidential Information Agreement,
Executive shall not for a period of two (2) years following Executive’s termination of employment for any reason, either on Executive’s own account or jointly with or as a manager, agent, officer, employee, consultant, partner, joint
venturer, owner or stockholder or otherwise on behalf of any other person, firm or corporation, directly or indirectly solicit or attempt to solicit away from the Company any of its officers or employees or offer employment to any person who is an
officer or employee of the Company; provided, however, that a general advertisement to which an employee of the Company responds shall in no event be deemed to result in a breach of this Section 8(b). Executive also agrees not to
harass or disparage the Company or its employees, clients, directors or agents or divert or attempt to divert any actual or potential business of the Company. If it is determined by a court of competent jurisdiction in any state that any

  
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restriction in this Section 8(b) is excessive in duration or scope or is unreasonable or unenforceable under the laws of that state, it is the intention of the parties that such restriction
may be modified or amended by the court to render it enforceable to the maximum extent permitted by the law of that state. 

9. Executive Representations. Executive warrants and represents that (a) he has not filed or authorized the filing
of any complaints, charges or lawsuits against the Company or any affiliate of the Company with any governmental agency or court, and that if, unbeknownst to Executive, such a complaint, charge or lawsuit has been filed on his behalf, he will use
reasonable best efforts to immediately cause it to be withdrawn and dismissed, and (b) he has no known workplace injuries or occupational diseases and has been provided and/or has not been denied any leave requested under the Family and Medical
Leave Act or any similar state law, and (c) he has received the Company’s Insider Trading Compliance Policy and agrees to continue to abide by all applicable terms therein, including specifically, Section IV (C) which states,
“With the exception of the preclearance requirement, the insider trading laws continue to apply to all transactions in the Company’s securities even after termination of service of service to the Company. If an individual is in the
possession of material non-public information when his or her service terminates, that individual may not trade in the Company’s securities until that information has become public or is no longer material.” 

10. No Assignment by Executive. Executive warrants and represents that no portion of any of the matters released herein,
and no portion of any recovery or settlement to which Executive might be entitled, has been assigned or transferred to any other person, firm or corporation not a party to this Agreement, in any manner, including by way of subrogation or operation
of law or otherwise. If any claim, action, demand or suit should be made or instituted against the Company or any other Releasee because of any actual assignment, subrogation or transfer by Executive, Executive agrees to indemnify and hold harmless
the Company and all other Releasees against such claim, action, suit or demand, including necessary expenses of investigation, attorneys’ fees and costs. In the event of Executive’s death, this Agreement shall inure to the benefit of
Executive and Executive’s executors, administrators, heirs, distributees, devisees, and legatees. None of Executive’s rights or obligations may be assigned or transferred by Executive, other than Executive’s rights to payments
hereunder, which may be transferred only upon Executive’s death by will or operation of law. 
 11. Governing
Law. This Agreement shall be construed and enforced in accordance with, and the rights of the parties shall be governed by, the laws of the State of California or, where applicable, United States federal law, in each case, without regard to any
conflicts of laws provisions or those of any state other than California. 
 12. Miscellaneous. This Agreement,
together with the Confidential Information Agreement, the Stock Agreements and the form of General Release of Claims attached as Exhibit A hereto comprise the entire agreement between the parties with regard to the subject matter hereof and
supersedes, in their entirety, any other agreements between Executive and the Company with regard to the subject matter hereof. Executive acknowledges that there are no other agreements, written, oral or implied, and that he may not rely on any
prior negotiations, discussions, representations or agreements. This Agreement may be modified only in writing, and such writing must be signed by both parties and recited that it is intended to modify this Agreement. This Agreement may be executed
in separate counterparts, each of which is deemed to be an original and all of which taken together constitute one and the same agreement. 

  
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 13. Company Assignment and Successors. The Company shall assign its rights
and obligations under this Agreement to any successor to all or substantially all of the business or the assets of the Company (by merger or otherwise). This Agreement shall be binding upon and inure to the benefit of the Company and its successors,
assigns, personnel and legal representatives. 
 14. Maintaining Confidential Information. Executive reaffirms his
obligations under the Confidential Information Agreement. Executive acknowledges and agrees that the payments provided in Sections 2 and 3 above shall be subject to Executive’s continued compliance with Executive’s obligations under the
Confidential Information Agreement. 
 15. Executive’s Cooperation. Executive further agrees that: 

(a) Transition. From the Effective Date through the Resignation Date, Executive shall continue to provide full-time
services to the Company, shall continue to discharge all duties of the position of the Chief Scientific Officer (“CSO”) until such time as a new is retained, and shall cooperate with the Company in the preparation and presentation
of public statements regarding Executive’s planned departure from the Company and provide reasonable assistance to the new CSO and other members of management. Following the Resignation Date, except as provided in Section 15(b), below or
otherwise agreed by Executive, Executive’s obligation of continued cooperation shall be limited to the provision of reasonable assistance with respect to intellectual property matters relating to the Company’s issued patents and patent
applications pending as of the Resignation Date. 
 (b) Investigations. After the Resignation Date, Executive shall
use reasonable efforts to cooperate with the Company and its affiliates, upon the Company’s reasonable request, with respect to any internal investigation or administrative, regulatory or judicial proceeding involving matters within the scope
of Executive’s duties and responsibilities to the Company or its affiliates during his employment with the Company (including, without limitation, Executive being available to the Company upon reasonable notice for interviews and factual
investigations, appearing at the Company’s reasonable request to give testimony without requiring service of a subpoena or other legal process, and turning over to the Company all relevant Company documents which are or may have come into
Executive’s possession during his employment); provided, however, that any such request by the Company shall not be unduly burdensome or interfere with Executive’s personal schedule or ability to engage in gainful
employment, consulting or other work, and the Company shall pay, upon invoicing by Executive, all reasonably incurred fees for his time in so cooperating (which shall not exceed one thousand dollars ($1,000) per eight hour day), and reimburse
Executive for his actual, reasonable, out-of-pocket expenses (including without limitation, any and all reasonable attorney’s fees and costs) incurred in connection with providing any such cooperation. 

(Signature page(s) follow) 

  
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 IN WITNESS WHEREOF, the undersigned have caused this Transition and Separation Agreement to be
duly executed and delivered as of the date indicated next to their respective signatures below. 
  

							
	DATED: September 4, 2014	 		 	
		 		 	 /s/ Domnique Charmot, Ph.D.

		 		 	Dominique Charmot, Ph.D.
			
		 		 	ARDELYX, INC.
	DATED: September 4, 2014	 		 	
				
		 		 	By:	 	 /s/ Mike Raab

		 		 		 	Mike Raab, President & CEO

  
 S-1 

 EXHIBIT A 

GENERAL RELEASE OF CLAIMS 

This General Release of Claims (“Release”) is entered into as of
            , between Dominique Charmot, Ph.D. (“Executive”) and Ardelyx, Inc. (the “Company”) (collectively referred to herein as the
“Parties”), effective eight (8) days after Executive’s signature hereto (the “Effective Date”), unless Executive revokes his acceptance of this Release as provided in Paragraph 1(c), below. 

1. Executive’s Release of the Company. 

(a) Executive, on his own behalf and on behalf of his family members, heirs, executors, administrators, agents, and assigns,
hereby and forever releases the Company and its current and former officers, directors, employees, agents, investors, attorneys, affiliates, divisions, and subsidiaries, and predecessor and successor corporations and assigns (the
“Releasees”) from, and agrees not to sue concerning, or in any manner to institute, prosecute, or pursue, any claim, complaint, charge, duty, obligation, or cause of action relating to any matters of any kind, whether presently
known or unknown, suspected or unsuspected, that Executive may possess against any of the Releasees arising from any omissions, acts, facts, or damages that have occurred up until and including the date Executive signs this Release, including,
without limitation: 
 (i) any and all claims relating to or arising from Executive’s employment relationship with
Company and the termination of that relationship; 
 (ii) any and all claims for wrongful discharge of employment;
termination in violation of public policy; discrimination; harassment; retaliation; breach of contract, both express and implied; breach of covenant of good faith and fair dealing, both express and implied; promissory estoppel; negligent or
intentional infliction of emotional distress; fraud; negligent or intentional misrepresentation; negligent or intentional interference with contract or prospective economic advantage; unfair business practices; defamation; libel; slander;
negligence; personal injury; assault; battery; invasion of privacy; false imprisonment; conversion; and disability benefits; 

(iii) any and all claims for violation of any federal, state, or municipal statute, including, but not limited to,
Title VII of the Civil Rights Act of 1964; the Civil Rights Act of 1991; the Rehabilitation Act of 1973; the Americans with Disabilities Act of 1990; the Equal Pay Act; the Fair Labor Standards Act, except as prohibited by law; the Fair Credit
Reporting Act; the Age Discrimination in Employment Act of 1967; the Older Workers Benefit Protection Act; the Employee Retirement Income Security Act of 1974; the Worker Adjustment and Retraining Notification Act; the Family and Medical Leave Act,
except as prohibited by law; the Sarbanes-Oxley Act of 2002, except as prohibited by law; the Uniformed Services Employment and Reemployment Rights Act; the California Family Rights Act; the California Labor Code, except as prohibited by law; the
California Workers’ Compensation Act, except as prohibited by law; and the California Fair Employment and Housing Act; 

(iv) any and all claims for violation of the federal or any state constitution; 

  
 A-1 

 (v) any and all claims arising out of any other laws and regulations relating to
employment or employment discrimination; 
 (vi) any claim for any loss, cost, damage, or expense arising out of any dispute
over the non-withholding or other tax treatment of any of the proceeds received by Executive as a result of the Transition and Separation Agreement entered into between the Parties as of September 4, 2014 (the “Transition and Separation
Agreement”); 
 (vii) any claim for breach of contract or breach of the implied covenant of good faith and fair
dealing; 
 (viii) any and all claims for attorneys’ fees and costs. 

(b) Executive agrees that the release set forth in this Section shall be and remain in effect in all respects as a complete
general release as to the matters released. This release does not extend to any obligations incurred under the Transition and Separation Agreement or the Stock Agreements (each as defined in the Transition and Separation Agreement). This release
does not release claims or rights that cannot be released as a matter of law, including, but not limited to, claims under Division 3, Article 2 of the California Labor Code (which includes California Labor Code Section 2802 regarding indemnity
for necessary expenditures or losses by Executive) any other indemnification, defense, or hold-harmless rights Executive may have, and Executive’s right to bring to the attention of the Equal Employment Opportunity Commission or California
Department of Fair Employment and Housing claims of discrimination, harassment or retaliation; provided, however, that Executive does release his right to obtain damages for any such claims. This release does not release claims or rights that the
Executive may have as a shareholder of the Company or for vested benefits under any benefit plan or to continued participation in any such plan pursuant to the terms thereof or applicable law. 

(c) Acknowledgment of Waiver of Claims under ADEA. Executive acknowledges that he is waiving and releasing any rights he
may have under the Age Discrimination in Employment Act of 1967 (“ADEA”), and that this waiver and release is knowing and voluntary. Executive acknowledges that this waiver and release does not apply to any rights or claims that may
arise under the ADEA after the Effective Date of this Release. Executive acknowledges that the consideration given for this waiver and release is in addition to anything of value to which Executive was already entitled. Executive further
acknowledges that he has been advised by this writing that: (a) he should consult with an attorney prior to executing this Release; (b) he has twenty-one (21) days within which to consider this Release; (c) he has seven
(7) days following his execution of this Release to revoke this Release; (d) this Release shall not be effective until after the revocation period has expired and Executive will not receive the severance and other benefits provided by
Section 3 of the Transition and Separation Agreement; and (e) nothing in this Release prevents or precludes Executive from challenging or seeking a determination in good faith of the validity of this waiver under the ADEA, nor does it
impose any condition precedent, penalties, or costs for doing so, unless specifically authorized by federal law. In the event Executive signs this Release and returns it to the Company’s General Counsel in less than the 21-day period identified
above, Executive hereby acknowledges that he has freely and voluntarily chosen to waive the time period allotted for considering this Release. To revoke his acceptance of this Release, Executive must contact the Company’s General Counsel by
email at egrammer@ardelyx.com no later than 5 p.m. on the 7th day following Executive’s signature of this Release. 

  
 A-2 

 (d) California Civil Code Section 1542. Executive acknowledges that
he has been advised to consult with legal counsel and is familiar with the provisions of California Civil Code Section 1542, a statute that otherwise prohibits unknown claims, which provides as follows: 

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING
THE RELEASE, WHICH IF KNOWN BY HIM OR HER MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR. 
 Executive, being aware of
said code section, agrees to expressly waive any rights he may have thereunder, as well as under any other statute or common law principles of similar effect. 

2. Executive Representations. Executive represents and warrants that: 

(a) To Executive’s knowledge, Executive has returned to the Company all Company property in Executive’s possession
and if he discovers additional Company property in his possession he will promptly return it to the Company; 
 (b) Except as
Executive has informed the Company in writing, Executive is not owed wages, commissions, bonuses or other compensation, other than any payments that become due under Sections 3 and 4(b) of the Transition and Separation Agreement; 

(c) During the course of Executive’s employment Executive did not sustain any injuries for which Executive might be
entitled to compensation pursuant to worker’s compensation law or Executive has disclosed any injuries of which he is currently, reasonably aware for which he might be entitled to compensation pursuant to worker’s compensation law; 

(d) From the date Executive executed the Transition and Separation Agreement through the date Executive executes this Release,
Executive has not made any disparaging comments about the Company, nor will Executive do so in the future; and 
 (e)
Executive has not initiated any adversarial proceedings of any kind against the Company or against any other person or entity released herein, nor will Executive do so in the future with respect to any claims released hereby, except as specifically
allowed by this Release. 
 3. Continuing Obligations. Executive reaffirms his obligations under the Transition and
Separation Agreement and under the Confidential Information Agreement (as defined in the Transition and Separation Agreement). 

4. Cooperation with the Company. Executive reaffirms his obligations to cooperate with the Company pursuant to
Section 15 of the Transition and Separation Agreement. 
 5. Severability. The provisions of this Release are
severable. If any provision is held to be invalid or unenforceable, it shall not affect the validity or enforceability of any other provision. 

  
 A-3 

 6. Choice of Law. This Release shall in all respects be governed and
construed in accordance with the laws of the State of California, including all matters of construction, validity and performance, without regard to conflicts of law principles. 

7. Integration Clause. This Release and the Transition and Separation Agreement, the Confidential Information Agreement,
and the Option Agreements contain the Parties’ entire agreement with regard to the transition and separation of Executive’s employment, and supersede and replace any prior agreements as to those matters, whether oral or written. This
Release may not be changed or modified, in whole or in part, except by an instrument in writing signed by Executive and the President & Chief Executive Officer of the Company. 

8. Execution in Counterparts. This Release may be executed in counterparts with the same force and effectiveness as
though executed in a single document. Facsimile signatures shall have the same force and effectiveness as original signatures. 

9. Intent to be Bound. The Parties have carefully read this Release in its entirety; fully understand and agree to its
terms and provisions; and intend and agree that it is final and binding on all Parties. 
 (Signature page(s) follow) 

  
 A-4 

 IN WITNESS WHEREOF, and intending to be legally bound, the Parties have executed the foregoing on
the dates shown below. 
  

					
	EXECUTIVE	  		  	ARDELYX, INC.
			
	 /s/ Dominique Charmot
	  		  	 /s/ Mike Raab

	Dominique Charmot, Ph.D.	  		  	By: Mike Raab
		  		  	Title: President & CEO
			
	Date: September 4, 2014	  		  	Date: September 4, 20148K1001 Anderson - 2nd Amend to Employment Agmt Exhibit  09-08-14

		

			Exhibit 10.1

		

		
			SECOND AMENDMENT TO 
		

		
			EMPLOYMENT AGREEMENT
		

		
			 
		

		
			 
		

		
			This SECOND AMENDMENT (the “Amendment”) dated as of the 3rd  day of September, 2014, amends the Employment Agreement between CRYOLIFE, INC., A Florida corporation, (“CryoLife” or the “Company”) and STEVEN G. ANDERSON (the “Employee”) that is dated October 23, 2012 and was previously amended by a  First Amendment dated as of May 28th, 2014 (as so amended, the “Agreement”).
		

		
			 
		

		
			W I T N E S S E T H :
		

		
			 
		

		
			WHEREAS, the Company entered into an employment agreement dated July 7, 2014 to hire James Patrick Mackin as President and Chief Executive Officer of the Company effective on September 2, 2014 (the “Executive Hiring”); 
		

		
			 
		

		
			WHEREAS, the parties desire to amend certain provisions of the Agreement to make accommodation for the Executive Hiring;
		

		
			 
		

		
			WHEREAS, the parties desire the Amendment to become effective on September 2 (the “Amendment Effective Date”); and
		

		
			 
		

		
			WHEREAS, the Company’s Compensation Committee (the “Compensation Committee”) has recommended and its Board of Directors (the “Board”) has approved this Amendment.
		

		
			 
		

		
			NOW, THEREFORE, in consideration of the premises, the promises hereinafter set forth and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, it is hereby agreed, effective as of the Amendment Effective Date, as follows:
		

		
			 
		

			
	
			
				 A.
			Sections 1(a), 1(b) and 2(a) of the Agreement are hereby deleted in their entirety and replaced with the following sections:   

		
			 
		

		
			“1. EMPLOYMENT.
		

		
			 
		

			
	
			
				 (a)
			Position. CryoLife hereby employs Employee in the capacity of Executive Chairman and Employee hereby accepts such employment and also agrees to continue to serve as Chairman of the board of directors.

		
			 
		

			
	
			
				 (b)
			Employment Period.  Subject to the terms and conditions of this Agreement, the Employee’s employment as Executive Chairman shall commence on the Amendment Effective Date and end on December 31, 2016 (the “Employment Period”). 

		
			 
		

		
			2.EMPLOYMENT DUTIES.
		

		
			 
		

			
	
			
				 (a)
			Duties. Employee shall have the general powers, duties and responsibilities usually vested in the office of the Executive Chairman of a corporation, including those enumerated on Exhibit A attached to this Amendment, together with such additional powers as may be prescribed from time to time by the Board. Any additional powers, duties and responsibilities shall be substantially consistent with those customarily assigned to individuals serving as Executive Chairmen at comparable companies. Employee currently serves CryoLife as a director and as its Chairman of the board of directors. Subject to applicable law and regulation, including the Board’s 
		

		 

		

			1

		

		

			 

		

 

		

			Exhibit 10.1

		

			compliance with its fiduciary duties, Employee shall continue to be nominated to serve on the Board and remain as Chairman of the Board.

		
			 
		

			
	
			
				 B.
			This Amendment shall become effective if, and only if, James Patrick Mackin commences serving as President and Chief Executive Officer of the Company on the Amendment Effective Date. 

		
			 
		

			
	
			
				 C.
			Neither the Executive Hiring, this Amendment, nor the change in duties or performance obligations created by this Amendment shall constitute Good Reason or Cause under the Agreement.  

		
			 
		

			
	
			
				 D.
			This Amendment shall be governed by and construed in accordance with the laws of the State of Georgia, without reference to principles of conflict of laws.

		
			 
		

			
	
			
				 E.
			Except as amended pursuant to the terms of this Amendment, the Agreement shall continue in full force and effect according to its terms.

		
			 
		

		
			IN WITNESS WHEREOF, Employee has hereunder set his hand and, pursuant to the authorization from the Board, upon recommendation of the Compensation Committee, CryoLife has caused this Amendment to be executed in its name and on its behalf, all as of the day and year first written above.
		

		
			 
		

		
			 
		

		
			/s/ Steven G. Anderson
		

		
			Steven G. Anderson
		

		
			 
		

		
			 
		

		
			CRYOLIFE, INC.
		

		
			 
		

		
			 
		

		
			/s/ Ronald C. Elkins, M.D.
		

		
			Ronald C. Elkins, M.D.
		

		
			Director and Chairman,
		

		
			Compensation Committee
		

		

		

		 

		

			2

		

		

			 

		

 

		

			Exhibit 10.1

		

		Exhibit A – Duties  *
		

		
			 
		

			
	
			
				 1.
			

			
	
			
			Oversee and facilitate the assimilation of Pat Mackin into the roles of President and Chief Executive Officer.

			
	
			
				 2.
			

			
	
			
			Assist the President and Chief Executive Officer:

			
	
			
				 §
			

			
	
			
			with general advice and support; 

			
	
			
				 §
			

			
	
			
			in accessing Company resources and communicating with the Board; and 

			
	
			
				 §
			

			
	
			
			in communicating with important shareholders, business partners, the government and other relevant constituencies. 

			
	
			
				 3.
			

			
	
			
			Counsel, advise and support executive management, acting as a mentor or coach where appropriate and as requested by the Chief Executive Officer or the Board. 

			
	
			
				 4.
			

			
	
			
			Assist executive management with investor and customer relations.

			
	
			
				 5.
			

			
	
			
			Facilitate effective contributions by executive management and the Board. 

			
	
			
				 6.
			

			
	
			
			Assist in setting and implementing the Company’s strategic direction. 

			
	
			
				 7.
			

			
	
			
			Promote effective relationships between directors to facilitate effective Company oversight.

			
	
			
				 8.
			

			
	
			
			Assist the Board, in coordination with the Compensation Committee and Nominating and Corporate Governance Committee, in evaluating the performance of the President and Chief Executive Officer and meet with the President and Chief Executive Officer to discuss the evaluation.

			
	
			
				 9.
			

			
	
			
			Continue to represent the Company as its Founder, and as Executive Chairman, at events and functions as reasonably requested by the Chief Executive Officer. 

			
	
			
				 10.
			

			
	
			
			Assist in the initiation of constructive change and succession management in Board appointments (except that of any successor as Chairman) subject to board and shareholder approval. 

			
	
			
				 11.
			

			
	
			
			Assist the Board in focusing its time and efforts on matters of highest importance to the Company.

			
	
			
				 12.
			

			
	
			
			Assist with the creation of agendas for Board meetings. 

			
	
			
				 13.
			

			
	
			
			Serve as chair of all Board meetings.

			
	
			
				 14.
			

			
	
			
			Otherwise provide leadership to and assist in managing the Board. 

		
			* All of the duties identified in items 11 through 14 are contingent upon Employee remaining on the Board as Chairman of the Board. Whenever Employee ceases to serve in this function, these duties will be removed from the Employee’s responsibilities.
		

		
			 
		

		 

		

			3

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