Document:

EXHIBIT 10.9

 Exhibit 10.9 
 FORM OF 
 AMENDMENT TO THE 
 BALTIMORE COUNTY SAVINGS BANK, F.S.B. 
 CHANGE IN CONTROL SEVERANCE AGREEMENT

 WHEREAS,
                         (the “Executive”) entered into a change in control severance agreement with
Baltimore County Savings Bank, F.S.B.(the “Bank”) effective October 23, 2002 (the “Agreement”); and 
 WHEREAS,
the Bank and the Executive wish to amend the Agreement to: 
  

	 	•	 	 comply with Section 409A of the Internal Revenue Code of 1986, as amended and the regulatory guidance promulgated thereunder; and 

 

	 	•	 	 allow BCSB Bancorp, Inc. (the stock holding company formed in connection with the Bank’s second step conversion) to become a party to the Agreement as
guarantor; and 

 WHEREAS, BCSB Bancorp, Inc. has agreed to serve as guarantor under the Agreements; and 

WHEREAS, the Agreement provides that it may be amended or modified at any time prior to a change in control by means of a written instrument
signed by the parties. 
 NOW, THEREFORE, the Bank, BCSB Bancorp, Inc. and the Executive hereby agree to amend the Agreement as
follows: 
 FIRST CHANGE 
 Effective as of
the date hereof, Section 4 of the Agreement shall be deleted in its entirety and replaced with the following new Section 4: 
 “Timing of
Severance Payment. Any cash payable to the Executive under Section 3(a) of this Agreement shall be payable in a lump sum within 10 calendar days after the Executive’s termination of employment, provided, however, if, at the time of the
Executive’s termination of employment, the Executive is a “specified employee” (as defined in Section 409A of the Internal Revenue Code of 1986) and the payment under Section 3(a) is subject to Section 409A of the
Internal Revenue Code of 1986, then such payment shall not be made until six months and one day following the date of the Executive terminates employment, except as may otherwise be permitted under Section 409A of the Internal Revenue Code of
1986.” 
 SECOND CHANGE 
 Effective
as of the date hereof, Section 5(c)(i) of the Agreement shall be deleted in its entirety and replace with the following new Section 5(c)(i): 
 “(i) Notwithstanding anything in this Agreement to the contrary, in no event shall the aggregate payments or benefits to be made or afforded to the Executive under Section 3 of this Agreement (the
“Termination Benefits”) constitute an “excess parachute payment” under Section 280G of the Internal Revenue Code of 1986, as amended (the “Code”), or any successor thereto, and to avoid such a result, Termination
Benefits will be reduced, if necessary, to an amount 

 
which is one dollar ($1.00) less than three (3) times the Executive’s “base amount,” as determined in accordance with said
Section 280G of the Internal Revenue Code of 1986. The Executive shall determine the allocation of the required reduction among the Termination Benefits provided in Section 3 of this Agreement.” 
 THIRD CHANGE 
 Effective as of the date hereof,
Section 10 of the Agreement shall be amended to add the following subsection (e): 
 “(e) Source of Payments. The Bank shall make
all payments provided for under this Agreement. The Company, however, unconditionally guarantees all amounts and benefits due to Executive and, if the Bank does not timely pay or provide such amounts and benefits, the Company shall pay or provide
such amounts and benefits.” 
 IN WITNESS WHEREOF, the Bank and BCSB Bancorp, Inc. have caused this Amendment to be executed by
their duly authorized officers, and Executive has signed this Amendment on the              day of             ,
2007. 
  

					
	ATTEST:	 		 	BALTIMORE COUNTY SAVINGS BANK, F.S.B.
			
	   	 		 	   
		 		 	For the Board of Directors
			
	ATTEST:	 		 	BCSB BANCORP, INC.
		 		 	(as guarantor)
			
	   	 		 	   
		 		 	For the Board of Directors
			
	WITNESS:	 		 	EXECUTIVEFirst Supplemental Indenture

 Exhibit 4.1 
  

 VIROPHARMA INCORPORATED 
 ISSUER 
  

 WILMINGTON TRUST COMPANY 
 TRUSTEE 
  

 FIRST SUPPLEMENTAL INDENTURE

 Dated as of March 26, 2007 
  

 2.00% CONVERTIBLE SENIOR NOTES DUE 2017 
  

 TABLE OF CONTENTS 
  

					
	 	  	 	  	PAGE
		  	ARTICLE 1	  	
		  	DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION	  	
	SECTION 1.01.	  	Definitions.	  	2
	SECTION 1.02.	  	Acts of Holders of Notes.	  	13
	SECTION 1.03.	  	Notices, Etc. to the Trustee and Company.	  	14
	SECTION 1.04.	  	Effect of Headings and Table of Contents.	  	15
			
		  	ARTICLE 2	  	
		  	NOTE FORMS	  	
			
	SECTION 2.01.	  	Form Generally.	  	15
	SECTION 2.02.	  	Form of Note.	  	16
	SECTION 2.03.	  	Form of Notice of Conversion.	  	25
	SECTION 2.04.	  	Form of Assignment.	  	26
			
		  	ARTICLE 3	  	
		  	THE NOTES	  	
	SECTION 3.01.	  	Title And Terms.	  	27
	SECTION 3.02.	  	Denominations	  	27
	SECTION 3.03.	  	Global Notes; Non-global Notes; Book-entry Provisions.	  	27
	SECTION 3.04.	  	Persons Deemed Owners.	  	29
			
		  	ARTICLE 4	  	
		  	SATISFACTION AND DISCHARGE	  	
			
	SECTION 4.01.	  	Satisfaction And Discharge Of Indenture.	  	30
			
		  	ARTICLE 5	  	
		  	REMEDIES	  	
	SECTION 5.01.	  	Events Of Default.	  	30
	SECTION 5.02.	  	Acceleration Of Maturity; Rescission And Annulment.	  	32
	SECTION 5.03.	  	Unconditional Right Of Holders To Receive Principal And Interest And To Convert.	  	34
	SECTION 5.04.	  	Waiver Of Past Defaults.	  	34
	SECTION 5.05.	  	Waiver Of Stay, Usury Or Extension Laws.	  	34

  

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	 	  	ARTICLE 6	  	 
		  	[RESERVED]	  	
			
		  	ARTICLE 7	  	
		  	[RESERVED]	  	
			
		  	ARTICLE 8	  	
		  	SUPPLEMENTAL INDENTURES	  	
			
	SECTION 8.01.	  	Supplemental Indentures Without Consent Of Holders Of Notes.	  	35
	SECTION 8.02.	  	Supplemental Indentures With Consent Of Holders Of Notes.	  	36
	SECTION 8.03.	  	Notice Of Supplemental Indentures.	  	37
			
		  	ARTICLE 9	  	
		  	HOLDERS LISTS AND BY TRUSTEE AND COMPANY	  	
			
	SECTION 9.01.	  	Preservation Of Information.	  	38
	SECTION 9.02.	  	Reports By Company. 	  	38
			
		  	ARTICLE 10	  	
		  	COVENANTS	  	
	SECTION 10.01.	  	Payment Of Principal And Interest.	  	38
	SECTION 10.02.	  	Maintenance Of Offices Or Agencies.	  	39
	SECTION 10.03.	  	Existence.	  	39
	SECTION 10.04.	  	Statement By Officers As To Default.	  	40
			
		  	ARTICLE 11	  	
		  	[RESERVED]	  	
			
		  	ARTICLE 12	  	
		  	CONVERSION OF NOTES	  	
			
	SECTION 12.01.	  	Conversion Privilege And Conversion Rate.	  	40
	SECTION 12.02.	  	Exercise Of Conversion Privilege.	  	45
	SECTION 12.03.	  	Fractions Of Shares.	  	50
	SECTION 12.04.	  	Adjustment Of Conversion Rate.	  	52
	SECTION 12.05.	  	Notice Of Adjustments Of Conversion Rate.	  	62
	SECTION 12.06.	  	Company To Reserve Common Stock.	  	63
	SECTION 12.07.	  	Taxes On Conversions.	  	63
	SECTION 12.08.	  	Certain Covenants.	  	63

  

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	SECTION 12.09.	  	Cancellation Of Converted Notes.	  	63
	SECTION 12.10.	  	Provision In Case Of Effect Of Reclassification, Consolidation, Merger Or Sale.	  	64
	SECTION 12.11.	  	Responsibility Of Trustee For Conversion Provisions.	  	66
			
		  	ARTICLE 13	  	
		  	DISCHARGE	  	
			
	SECTION 13.01.	  	Discharge of Liability on Notes.	  	66
	SECTION 13.02.	  	Reinstatement.	  	67
	SECTION 13.03.	  	Officers’ Certificate; Opinion of Counsel.	  	68
			
		  	ARTICLE 14	  	
		  	REPURCHASE OF NOTES	  	
			
	SECTION 14.01.	  	Right To Require Repurchase Upon A Fundamental Change.	  	68

  

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 FIRST SUPPLEMENTAL INDENTURE, dated as of March 26, 2007 (the “First Supplemental
Indenture”), between VIROPHARMA INCORPORATED, a corporation duly organized and existing under the laws of the State of Delaware, having its principal office at 397 Eagleview Boulevard, Exton, Pennsylvania 19341 (herein called the
“Company”), and WILMINGTON TRUST COMPANY, a Delaware banking corporation, as Trustee hereunder (herein called the “Trustee”). 
 RECITALS OF THE COMPANY 
 The Company executed and delivered the Indenture (the “Original
Indenture”), dated as of March 19, 2007, to the Trustee to issue from time to time for its lawful purposes, among other securities, debt securities evidencing the Company’s senior unsecured Indebtedness. 
 Section 3.1 of the Original Indenture provides that by means of a supplemental indenture the Company may create one or more series of its debt
securities and establish the form, terms and provisions thereof. 
 All actions required to be taken under the Original Indenture with
respect to this First Supplemental Indenture have been taken. 
 The Company has duly authorized the creation of an issue of its 2.00%
Convertible Senior Notes due 2017 (herein called the “Notes”) of substantially the tenor and amount hereinafter set forth, and to provide therefor the Company has duly authorized the execution and delivery of this First Supplemental
Indenture. 
 All things necessary to make the Notes, when the Notes are executed by the Company and authenticated and delivered hereunder,
the valid obligations of the Company, and to make this First Supplemental Indenture a valid agreement of the Company, in accordance with their and its terms, have been done. Further, all things necessary to duly authorize the issuance of the Common
Stock (as defined below) of the Company issuable upon the conversion of the Notes, and to duly reserve for issuance the number of shares of Common Stock issuable upon such conversion, have been done. 
 NOW, THEREFORE, THIS FIRST SUPPLEMENTAL INDENTURE WITNESSETH: 
 For and in consideration of the premises and the purchase of the Notes by the Holders (as defined below) thereof, it is mutually covenanted and agreed, for the equal and proportionate benefit of all Holders of the
Notes, as follows: 

 ARTICLE 1 
 DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 
 SECTION 1.01. Definitions. 
 This First Supplemental Indenture shall constitute an integral part of the Original Indenture, and except to the extent expressly excluded herein, all of the terms of the Original Indenture are hereby incorporated by reference. 

Articles IV, V, and XV and Sections 6.7, 7.1, 7.2, 10.2, 12.1, 12.2, 12.3, 12.4, 12.5, 12.6, 12.8, 14.1 and 14.2 of the Original Indenture shall
not apply to the Notes. For all purposes of this First Supplemental Indenture, except as otherwise expressly provided or unless the context otherwise requires: 
 (a) capitalized terms used but not defined herein shall have the respective meanings assigned to them in the Original Indenture; 
 (b) terms defined both herein and in the Original Indenture shall have the meanings assigned to them herein; 
 (c) the terms defined in this Article 1 have the meanings assigned to them in this Article 1 and include the plural as well as the singular; 
 (d) all accounting terms not otherwise defined herein have the meanings assigned to them in accordance with generally accepted accounting principles in the United States, and, except as otherwise herein expressly
provided, the term “generally accepted accounting principles” with respect to any computation required or permitted hereunder shall mean such accounting principles as are generally accepted at the date of such computation; and 

(e) all other terms used in this First Supplemental Indenture, which are defined in the Trust Indenture Act or which are by reference therein defined
in the Securities Act (except as herein otherwise expressly provided or unless the context otherwise requires), shall have the meanings assigned to such terms in the Trust Indenture Act and in the Securities Act as in force at the date of the
execution of this First Supplemental Indenture. The words “herein,” “hereof” and “hereunder” and other words of similar import refer to this First Supplemental Indenture as a whole and not to any particular Article,
Section or other subdivision. 
 “Act,” when used with respect to any Holder of a Note, has the meaning specified in
Section 1.02. 
 “Additional Notes” means an unlimited amount of Notes (other than the Initial Notes) issued under this
First Supplemental Indenture in accordance with Section 3.03, as part of the same series as the Initial Notes. 
  

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 “Additional Shares” has the meaning specified in Section 12.01. 
 “Adjustment Determination Date” has the meaning specified in Section 12.04. 
 “Adjustment Event” has the meaning specified in Section 12.04. 
 “Affiliate” of any specified Person means any other Person directly or indirectly controlling or controlled by or under direct or
indirect common control with such specified Person. For the purposes of this definition, “control,” when used with respect to any specified Person, means the power to direct the management and policies of such Person, directly or
indirectly, whether through the ownership of voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 
 “Agent Member” means any member of, or participant in, the Depositary. 
 “American Depositary Receipts” means a negotiable United States security that represents a non-United States company’s publicly
traded equity. 
 “Applicable Procedures” means, with respect to any transfer or transaction involving a Global Note or
beneficial interest therein, the rules and procedures of DTC or any successor Depositary, in each case to the extent applicable to such transaction and as in effect from time to time. 
 “Capital Stock” means, for any entity, any and all shares, interests, rights to purchase, warrants, options, participations or other
equivalents of or interests in (however designated) stock issued by that entity. 
 “Common Stock” means the Common Stock,
par value $0.002 per share, of the Company authorized at the date of this instrument as originally executed or as such stock may be constituted from time to time. Subject to the provisions of Section 12.10, shares issuable upon conversion of
Notes shall include only shares of Common Stock or shares of any class or classes of common stock resulting from any reclassification or reclassifications thereof; provided, however, that if at any time there shall be more than one
such resulting class, the shares so issuable on conversion of Notes shall include shares of all such classes, and the shares of each such class then so issuable shall be substantially in the proportion which the total number of shares of such class
resulting from all such reclassifications bears to the total number of shares of all such classes resulting from all such reclassifications. 
 “common stock” includes any stock of any class of Capital Stock which has no preference in respect of dividends or of amounts payable in the event of 

  

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any voluntary or involuntary liquidation, dissolution or winding up of the issuer thereof and which is not subject to redemption by the issuer thereof.

 “Continuing Directors” means (i) individuals who on the Issue Date constituted the Board of Directors and
(ii) any new directors whose election to the Board of Directors or whose nomination for election by the Company’s stockholders was approved by at least a majority of the Company’s directors then still in office (or a duly constituted
committee thereof), either who were directors on the Issue Date or whose election or nomination for election was previously so approved. 
 “Conversion Agent” means any Person authorized by the Company to convert Notes in accordance with Article 12. The Company has initially appointed the Trustee as its Conversion Agent pursuant to Section 10.02.

 “Conversion Date” has the meaning specified in Section 12.02. 
 “Conversion Obligation” has the meaning specified in Section 12.01. 
 “Conversion Price” means at any time the amount equal to $1,000 divided by the then current Conversion Rate. 
 “Conversion Rate” has the meaning specified in Section 12.01. 
 “Corporate Trust Office” means the office of the Trustee at which at any particular time the trust created by this First Supplemental
Indenture shall be principally administered (which at the date of this First Supplemental Indenture is located at Rodney Square North, 1100 North Market Street, Wilmington, Delaware 19890, Attention: Corporate Client Services (ViroPharma
Incorporated)). 
 “corporation” means a corporation, company, association, joint-stock company or business trust.

 “Daily Conversion Value” means, for each of the 25 consecutive VWAP Trading Days during the Observation Period,
one-twenty-fifth (1/25) of the product of (a) the applicable Conversion Rate and (b) the Daily VWAP of the Common Stock (or the Reference Property pursuant to Section 12.10) on such VWAP Trading Day, as determined by the Company.
Any such determination by the Company shall be conclusive absent manifest error. 
 “Daily Settlement Amount” means, for
each of the 25 VWAP Trading Days during the Observation Period, 
 (i) cash equal to the lesser of (x) $40 and
(y) the Daily Conversion Value relating to such VWAP Trading Day; and 
  

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 (ii) if such Daily Conversion Value exceeds $40, a number of shares of Common Stock equal
to (A) the difference between such Daily Conversion Value and $40, divided by (B) the Daily VWAP of the Common Stock for such VWAP Trading Day, subject to adjustment pursuant to Section 12.04(m). 
 “Daily VWAP” means for each of the 25 consecutive VWAP Trading Days during the Observation Period, the per share volume-weighted average
price as displayed under the heading “Bloomberg VWAP” on Bloomberg page VPHM.Q <equity> AQR (or any equivalent successor page) in respect of the period from the scheduled open of trading on the principal trading market for the Common
Stock to the scheduled close of trading on such market on such VWAP Trading Day (or if such volume-weighted average price is unavailable, the market value of one share of Common Stock on such VWAP Trading Day using a volume-weighted method as
determined by a nationally recognized independent investment banking firm retained by the Board of Directors for this purpose. 
 “Default” means any event which is, or after notice or lapse of time or both would become, an Event of Default pursuant to Section 5.01. 
 “Distributed Property” has the meaning specified in Section 12.04. 
 “Dollar,” “U.S. $” or “$” means a dollar or other equivalent unit in such coin or currency of the United States as at the time shall be legal tender for the payment of public and private
debts. 
 “DTC” means The Depository Trust Company, a New York corporation, or any successor. 
 “Effective Date” has the meaning specified in Section 12.01. 
 “Event of Default” has the meaning specified in Section 5.01. 
 “Ex-Date” means, with respect to any issuance or distribution on the Common Stock or any other equity security, the first date on which
the shares of Common Stock or such other equity security trade on the relevant exchange or in the relevant market, regular way, without the right to receive such issuance or distribution. 
 “Extension Fee” has the meaning specified in Section 5.02. 
 “Extension Right” has the meaning specified in Section 5.02. 
 “Final Observation Period” means with respect to any Conversion Date that occurs on or after the 30th Scheduled Trading Day prior to the
Maturity Date, and irrespective of whether the Company has made the Net Share Settlement 

  

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Election or not, the 25 consecutive VWAP Trading Day period beginning on and including the 27th Scheduled Trading Day prior to the Maturity Date (whether or
not the Maturity Date is a Scheduled Trading Day) (or if such day is not a VWAP Trading Day, the next succeeding VWAP Trading Day). 
 “First Supplemental Indenture” has the meaning specified in the first paragraph of this instrument. 
 “Fundamental Change” will be deemed to have occurred at the time after the Notes are originally issued that any of the following occurs: 
 (1) any Person acquires beneficial ownership directly or indirectly, through a purchase, merger or other acquisition transaction or series
of transactions, of shares of the Company’s Capital Stock entitling the Person to exercise 50% or more of the total voting power of all shares of the Company’s Capital Stock entitled to vote generally in elections of directors, other than
an acquisition by the Company, any of the Company’s Subsidiaries or any of the Company’s employee benefit plans (for purposes of this clause (1), whether a Person is a “beneficial owner” shall be determined in accordance with
Rule 13d-3 under the Exchange Act, and “Person” shall include any syndicate or group that would be deemed to be a “person” under Section 13(d)(3) of the Exchange Act); provided that this clause (1) shall not
apply to a merger of the Company with or into a wholly-owned subsidiary of a company that has a class of common stock or American Depositary Receipts in respect of common stock traded on any of the New York Stock Exchange, the American Stock
Exchange, the NASDAQ Global Select Market or the NASDAQ Global Market (or any of their respective successors) if immediately following the transaction or series of transactions (a) the consideration received by the holders of Common Stock
immediately before such transaction entitles them to exercise, directly or indirectly, 50% or more of the voting power of all shares of Capital Stock entitled to vote generally in the election of directors of such parent company and (b) such
parent company fully and unconditionally guarantees all obligations of such continuing or surviving corporation under the Notes and this First Supplemental Indenture on a senior basis on terms and pursuant to a supplemental indenture reasonably
satisfactory to the Trustee; or 
 (2) the Company (i) merges or consolidates with or into any other Person (other than a
Subsidiary), another Person merges with or into the Company, or the Company conveys, sells, transfers or leases all or substantially all of the Company’s assets to another Person or (ii) engages in any recapitalization, reclassification or
other transaction in which all or substantially all of the Common Stock is exchanged for or converted into 

  

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cash, securities or other property, in each case other than a merger or consolidation: 
 (a) that does not result in a reclassification, conversion, exchange or cancellation of the Company’s outstanding Common Stock;

 (b) pursuant to which consideration received by the holders of the Company’s Common Stock immediately prior to the
transaction entitles them to exercise, directly or indirectly, 50% or more of the voting power of all shares of Capital Stock entitled to vote generally in the election of directors of either (x) the continuing or surviving corporation or
(y) a corporation that directly or indirectly owns 100% of the Capital Stock of such continuing or surviving corporation, in either case, immediately after the transaction; provided that, in the case of this clause (y), such parent
corporation fully and unconditionally guarantees all obligations of such continuing or surviving corporation under the Notes and this First Supplemental Indenture on a senior basis on terms and pursuant to a supplemental indenture reasonably
satisfactory to the Trustee; or 
 (c) which is effected solely to change the Company’s jurisdiction of incorporation and
results in a reclassification, conversion or exchange of outstanding shares of the Company’s Common Stock solely into shares of common stock of the surviving entity; or 
 (3) the Company’s Continuing Directors do not constitute a majority of Board of Directors (or, if applicable, a successor Person to
the Company); or 
 (4) the Company is liquidated or dissolved or holders of Common Stock approve any plan or proposal for the
Company’s liquidation or dissolution; or 
 (5) shares of Common Stock, or shares of any other Capital Stock or American
Depositary Receipts in respect of shares of Capital Stock into which the Notes are convertible pursuant to the terms of this First Supplemental Indenture, are not listed for trading on any of the New York Stock Exchange, the American Stock Exchange,
the NASDAQ Global Select Market or the NASDAQ Global Market (or any of their respective successors). 
  

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 “Fundamental Change Expiration Time” has the meaning specified in Section 14.01.

 “Fundamental Change Repurchase Date” has the meaning specified in Section 14.01. 
 “Fundamental Change Repurchase Notice” has the meaning specified in Section 14.01. 
 “Fundamental Change Repurchase Price” has the meaning specified in Section 14.01. 
 “Fundamental Change Repurchase Right Notice” has the meaning specified in Section 14.01. 
 “Global Note” means a Note that is registered in the Register in the name of a Depositary or a nominee thereof. 
 “Holder” means the Person in whose name the Note is registered in the Register. 
 “Initial Notes” means the first $225,000,000 aggregate principal amount of the Notes issued under this First Supplemental Indenture on
the date hereof. The Initial Notes and the Additional Notes shall be treated as a single class for all purposes under this First Supplemental Indenture, and unless the context otherwise requires, all references to the Notes shall include the Initial
Notes and any Additional Notes. 
 “Interest Payment Date” means March 15 and September 15 of each year beginning
September 15, 2007. 
 “Issue Date” means March 26, 2007. 
 “Last Reported Sale Price” means, with respect to the Common Stock or any other security for which a Last Reported Sale Price must be
determined, on any date, the closing sale price per share of the Common Stock or unit of such other security (or, if no closing sale price is reported, the average of the last bid and last ask prices or, if more than one in either case, the average
of the average last bid and the average last ask prices) on such date as reported in composite transactions for the principal United States national or regional securities exchange on which it is then traded, if any. If the Common Stock or such
other security is not listed for trading on a United States national or regional securities exchange on the relevant date, the Last Reported Sale Price shall be the average of the last quoted bid and ask prices per share of Common Stock or such
other security in the over-the-counter market on the relevant date, as reported by the National Quotation Bureau or similar organization. In absence of such quotation, 

  

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the Last Reported Sale Price shall be the average of the mid-point of the last bid and ask prices for the Common Stock or such other security on the relevant
date from each of at least three nationally recognized independent investment banking firms, which may include any or all of the Underwriters, selected from time to time by the Board of Directors of the Company for that purpose. The Last Reported
Sale Price shall be determined without reference to extended or after hours trading. Any such determination shall be made by the Company and shall be conclusive absent manifest error. 
 “Market Disruption Event” means the occurrence or existence on any Scheduled Trading Day for the Common Stock of any suspension or
limitation imposed on trading (by reason of movements in price exceeding limits permitted by the stock exchange or otherwise) in the Common Stock or in any options contracts or futures contracts relating to the Common Stock, and such suspension or
limitation occurs or exists at any time within the 30 minutes prior to the closing time of the relevant exchange on such day. 
 “Maturity,” when used with respect to any Notes, means the date on which the principal of such Notes becomes due and payable as therein or herein provided, whether on the Maturity Date or by declaration of acceleration,
exercise of the repurchase right set forth in Article 14 or otherwise. 
 “Maturity Date,” means, with respect to the Notes,
March 15, 2017. 
 “Measurement Period” has the meaning specified in Section 12.01. 
 “Merger Event” has the meaning specified in Section 12.10. 
 “Net Share Settlement Election” has the meaning specified in Section 12.02(b). 
 “Notes” has the meaning ascribed to it in the fourth paragraph under the caption “Recitals of the Company.” Unless the context
otherwise requires, all references to the Notes shall include the Initial Notes and any Additional Notes. 
 “Notice of
Conversion” has the meaning specified in Section 12.02. 
 “Observation Period” means, with respect to any
Notes: 
 (i) with respect to any Conversion Date that occurs on or after the 30th Scheduled Trading Day prior to the Maturity
Date, the 25 consecutive VWAP Trading Day period beginning on and including the 27th Scheduled Trading Day prior to the Maturity Date (whether or not the Maturity Date is a Scheduled Trading Day) (or if such day is not a VWAP Trading Day, the next
succeeding VWAP Trading Day); and 
  

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 (ii) in all other instances, the 25 consecutive VWAP Trading Day period beginning on and
including the third VWAP Trading Day after the related Conversion Date in respect of such Notes. 
 “Officers’
Certificate” means a certificate signed by (i) the Chairman of the Board or the Chief Executive Officer, the President or any Vice President and by (ii) the Chief Financial Officer, Controller, Treasurer, Assistant Treasurer,
Corporate Secretary or Assistant Corporate Secretary and delivered to the Trustee. One of the Officers signing an Officers’ Certificate given pursuant to Section 10.04 shall be the principal executive, financial or accounting officer of
the Company. 
 “Original Indenture” has the meaning specified in the first paragraph under the caption “Recitals of
the Company.” 
 “Outstanding,” when used with respect to the Notes, means, as of the date of determination, all Notes
theretofore authenticated and delivered under this First Supplemental Indenture, except: 
 (i) Notes theretofore canceled by
the Trustee or delivered to the Trustee for cancellation; 
 (ii) Notes for the payment of which money in the necessary amount
has been theretofore deposited with the Trustee or any Paying Agent (other than the Company) in trust or set aside and segregated in trust by the Company (if the Company shall act as its own Paying Agent) for the Holders of such Notes in accordance
with the terms of the Original Indenture; 
 (iii) Notes which have been paid pursuant to Section 3.7 of the Original
Indenture or in exchange for or in lieu of which other Notes have been authenticated and delivered pursuant to this First Supplemental Indenture; and 
 (iv) Notes converted into Common Stock pursuant to Article 12; 
 provided, however, that, in determining
whether the Holders of the requisite principal amount of Outstanding Notes are present at a meeting of Holders of Notes for quorum purposes or have given any request, demand, authorization, direction, notice, consent or waiver hereunder, Notes owned
by the Company or any other obligor upon the Notes or any Affiliate of the Company or such other obligor shall be disregarded and deemed not to be Outstanding, except that, in determining whether the Trustee shall be protected in relying upon any
such determination as to the presence of a quorum or upon any such request, demand, authorization, direction, notice, consent or waiver, only Notes which a 

  

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Responsible Officer of the Trustee has been notified in writing to be so owned shall be so disregarded. Notes so owned which have been pledged in good faith
may be regarded as Outstanding if the pledgee is not the Company or any other obligor upon the Notes or any Affiliate of the Company or such other obligor, and the Trustee shall be protected in relying upon an Officers’ Certificate to such
effect. 
 “Paying Agent” means any Person authorized by the Company to pay the principal of or interest on any Notes on
behalf of the Company and, except as otherwise specifically set forth herein, such term shall include the Company if it shall act as its own Paying Agent. The Company has initially appointed the Trustee as its Paying Agent pursuant to
Section 10.02. 
 “Person” means any individual, corporation, limited liability company, partnership, joint venture,
trust, estate, unincorporated organization or government or any agency or political subdivision thereof and any syndicate or group that would be deemed a “person” under Section 13(d)(3) of the Exchange Act. 
 “Place of Conversion” has the meaning specified in Section 3.01. 
 “Place of Payment” has the meaning specified in Section 3.01. 
 “Predecessor Note” of any particular Note means every previous Note evidencing all or a portion of the same debt as that evidenced by
such particular Note; and, for the purposes of this definition, any Note authenticated and delivered under Section 3.7 of the Original Indenture in exchange for or in lieu of a mutilated, destroyed, lost or stolen Note shall be deemed to
evidence the same debt as the mutilated, destroyed, lost or stolen Note. 
 “Press Release” means any press release issued
by the Company and disseminated to Reuters Business News Services and Bloomberg News Services. 
 “Prospectus Supplement”
means the final prospectus supplement dated March 20, 2007 filed with the SEC in connection with the offering of the Notes. 
 “Record Date” means any Regular Record Date or Special Record Date. 
 “Record Date Period” means
the period from the close of business of any Regular Record Date next preceding any Interest Payment Date to 9:00 a.m., New York City time, on such Interest Payment Date. 
 “Reference Property” has the meaning specified in Section 12.10. 
 “Regular
Record Date” for interest payable in respect of any Note on any Interest Payment Date means the close of business on March 1 or September 1 

  

 11 

 
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. 
 “Scheduled Trading Day” means a day that is scheduled to be a Trading Day on the principal United States national or regional securities
exchange or market on which the Common Stock is listed or admitted for trading or, if the Common Stock is not listed or admitted for trading on any exchange or market, a Business Day. 
 “Significant Subsidiary” means, with respect to any Person, a Subsidiary of such Person that would constitute a “significant
subsidiary” as such term is defined under Rule 1-02 of Regulation S-X under the Securities Act and the Exchange Act. 
 “Spin-Off” has the meaning specified in Section 12.04. 
 “Stock Price” means the price paid
per share of Common Stock in connection with a Fundamental Change pursuant to which Additional Shares shall be added to the Conversion Rate as set forth in Section 12.01(d), which shall be equal to (i) if holders of Common Stock receive
only cash in such Fundamental Change, the cash amount paid per share of Common Stock and (ii) in all other cases, the average of the Last Reported Sale Prices of the Common Stock over the ten consecutive Trading Day period ending on the Trading
Day preceding the Effective Date of such Fundamental Change. 
 “Stock Record Date” has the meaning specified in
Section 12.04. 
 “Subsidiary” means a corporation more than 50% of the outstanding voting stock of which is owned,
directly or indirectly, by the Company or by one or more other Subsidiaries, or by the Company and one or more other Subsidiaries. For the purposes of this definition, “voting stock” means stock or other similar interests in the
corporation which ordinarily has or have voting power for the election of directors, or persons performing similar functions, whether at all times or only so long as no senior class of stock or other interests has or have such voting power by reason
of any contingency. 
 “Successor Note” of any particular Note means every Note issued after, and evidencing all or a
portion of the same debt as that evidenced by, such particular Note; and, for the purposes of this definition, any Note authenticated and delivered under Section 3.7 of the Original Indenture in exchange for or in lieu of a mutilated,
destroyed, lost or stolen Note shall be deemed to evidence the same debt as the mutilated, destroyed, lost or stolen Note. 
 “Trading Day” means a day during which (i) trading in the Common Stock generally occurs and (ii) there is no Market Disruption Event. 
  

 12 

 “Trading Price” with respect to any Notes, on any date of determination, means the
average of the secondary market bid quotations obtained by the Trustee for $2.0 million principal amount of such Notes at approximately 3:30 p.m., New York City time, on such determination date from three independent nationally recognized securities
dealers, which may include any or all of the Underwriters, selected by the Company; provided that if three such bids cannot reasonably be obtained by the Trustee, but two such bids are obtained, then the average of the two bids shall be used,
and if only one such bid can reasonably be obtained by the Trustee, that one bid shall be used. Any such determination by the Trustee shall be conclusive absent manifest error. 
 “Trading Price Condition” has the meaning specified in Section 12.01. 
 “Trigger Event” has the meaning specified in Section 12.04. 
 “Underwriters” means Goldman, Sachs & Co, Credit Suisse Securities (USA) LLC, Piper Jaffray & Co. and any underwriters
of Additional Notes. 
 “Underwriting Agreement” means the Underwriting Agreement, dated as of March 20, 2007 between
the Company and the Underwriters, as such agreement may be amended from time to time. 
 “VWAP Market Disruption Event”
means (i) a failure by the principal United States national or regional securities exchange or market on which the Common Stock is listed or admitted to trading to open for trading during its regular trading session or (ii) the occurrence
or existence prior to 1:00 p.m. New York City time on any Scheduled Trading Day for the Common Stock for an aggregate one half-hour period of any suspension or limitation imposed on trading (by reason of movements in price exceeding limits permitted
by the stock exchange or otherwise) in the Common Stock or in any options contracts or futures contracts relating to the Common Stock. 
 “VWAP Trading Day” means a day during which (i) trading in the Common Stock generally occurs on the principal United States national or regional securities exchange or market on which the Common Stock is listed or
admitted for trading and (ii) there is no VWAP Market Disruption Event. For purposes of determining payment upon conversion of the Notes in accordance with Section 12.02 (including, for the avoidance of doubt, for purposes of the
definition of “Observation Period” in Section 12.02), if the Common Stock is not so listed or traded, then “VWAP Trading Day” shall mean “Business Day.” 
 SECTION 1.02. Acts of Holders of Notes. 
 (a) Subject to Article 5 of this First Supplemental Indenture and Articles VII and VIII of the Original Indenture, upon actual receipt by the Trustee 

  

 13 

 
from any Holder of (i) any notice of Default or breach referred to in Section 5.01(e), if such Default or breach has occurred and is continuing and
the Trustee shall not have given such a notice to the Company, (ii) any declaration of acceleration referred to in Section 5.02, if an Event of Default has occurred and is continuing and the Trustee shall not have given such a declaration
to the Company, or (iii) any direction referred to in Section 7.6 of the Original Indenture, if the Trustee shall not have taken the action specified in such direction, then, with respect to clauses (ii) and (iii), a record date shall
automatically and without any action by the Company or the Trustee be set for determining the Holders entitled to join in such declaration or direction, which record date shall be the close of business on the 10th calendar day (or, if such day is
not a Business Day, the first Business Day thereafter) following the calendar day on which the Trustee receives such declaration or direction, and, with respect to clause (i), the Trustee may set any calendar day as a record date for the purpose of
determining the Holders entitled to join in such notice of Default. Promptly after such receipt by the Trustee of any such declaration or direction referred to in clause (ii) or (iii), and promptly after setting any record date with respect to
clause (i), and as soon as practicable thereafter, the Trustee shall notify the Company and the Holders of any such record date so fixed. The Holders on such record date (or their duly appointed agents or proxies), and only such Persons, shall be
entitled to join in such notice, declaration or direction, whether or not such Holders remain Holders after such record date; provided that, unless such notice, declaration or direction shall have become effective by virtue of Holders of the
requisite principal amount of Notes on such record date (or their duly appointed agents or proxies) having joined therein (an “Act”) on or prior to the 90th calendar day after such record date, such notice, declaration or direction
shall automatically and without any action by any Person be canceled and of no further effect. Nothing in this paragraph shall be construed to prevent a Holder (or a duly appointed agent or proxy thereof) from giving, before or after the expiration
of such 90-calendar day period, a notice, declaration or direction contrary to or different from, or, after the expiration of such period, identical to, the notice, declaration or direction to which such record date relates, in which event a new
record date in respect thereof shall be set pursuant to this paragraph. For the avoidance of doubt, nothing in this paragraph shall be construed to render ineffective any notice, declaration or direction of the type referred to in this paragraph
given at any time to the Trustee and the Company by Holders (or their duly appointed agents or proxies) of the requisite principal amount of Notes on the date such notice, declaration or direction is so given. 
 SECTION 1.03. Notices, Etc. to the Trustee and Company. 
 Any request, demand, authorization, direction, notice, consent, election, waiver or other Act of Holders of Notes or other document provided or permitted
by this First Supplemental Indenture to be made upon, given or furnished to, or filed with, 
  

 14 

 (a) the Trustee by any Holder of Notes or by the Company shall be sufficient for every purpose hereunder
if made, given, furnished or filed in writing (which may be via facsimile) to or with a Responsible Officer of the Trustee and received at its Corporate Trust Office, Attention: Corporate Client Services (ViroPharma Incorporated). 
 (b) the Company by the Trustee or by any Holder of Notes shall be sufficient for every purpose hereunder (unless otherwise herein expressly provided) if
in writing, mailed, first-class postage prepaid, or telecopied and confirmed by mail, first-class postage prepaid, or delivered by hand or overnight courier, addressed to the Company at 397 Eagleview Boulevard, Exton, Pennsylvania 19341, Attention:
Thomas F. Doyle, Vice President, General Counsel and Secretary, or at any other address previously furnished in writing to the Trustee by the Company. 
 SECTION 1.04. Effect of Headings and Table of Contents. 
 The Article and Section headings
herein and the Table of Contents are for convenience only and shall not affect the construction hereof. 
 ARTICLE 2 
 NOTE FORMS 
 SECTION 2.01. Form Generally. 
 The Notes shall be in substantially the form set forth in this Article 2, with such
appropriate insertions, omissions, substitutions and other variations as are required or permitted by this First Supplemental Indenture, and may have such letters, numbers or other marks of identification and such legends or endorsements placed
thereon as may be required to comply with the rules of any securities exchange, the Code, and regulations thereunder, or as may, consistent herewith, be determined by the officers executing such Notes, as evidenced by their execution thereof. The
Company shall furnish any such legends and endorsements to the Trustee in writing. All Notes shall be in fully registered form. 
 Notices of
Conversion shall be in substantially the form set forth in Section 2.03. 
 The Notes shall be printed, lithographed, typewritten or
engraved or produced by any combination of these methods or may be produced in any other manner permitted by the rules of any automated quotation system or securities exchange (including on steel engraved borders if so required by any securities
exchange upon which the Notes may be listed) on which the Notes may be listed 

  

 15 

 
for trading, as the case may be, all as determined by the officers executing such Notes, as evidenced by their execution thereof. 
 SECTION 2.02. Form of Note. 
 [FORM OF FACE OF NOTE] 
 THE FOLLOWING LEGEND SHALL APPEAR ON THE FACE OF EACH GLOBAL NOTE: 
 THIS NOTE IS A GLOBAL NOTE WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITARY OR A NOMINEE OF
THE DEPOSITARY, WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE AND ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS NOTE FOR ALL PURPOSES. 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY
CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN DEFINITIVE REGISTERED FORM IN THE LIMITED CIRCUMSTANCES REFERRED TO IN THE
INDENTURE, THIS GLOBAL NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE
TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. 
  

 16 

 VIROPHARMA INCORPORATED 
 2.00% Convertible Senior Notes due 2017 
 No.
                                       
                                        
                                        
                             $ 
 CUSIP No.                      
 VIROPHARMA INCORPORATED, a corporation duly organized and existing under the laws of the State of Delaware (herein called the “Company,” which term includes any successor Person under the Indenture
referred to on the reverse hereof), for value received, hereby promises to pay to                     , or registered assigns, the principal
sum of              United States Dollars (U.S. $            ) [if this Note is a Global Note, then insert
— (which principal amount may from time to time be decreased to such other principal amounts by adjustments made on the records of the Registrar hereinafter referred to in accordance with the Indenture)] on March 15, 2017, and to pay
interest thereon, from March 26, 2007, or from the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semi-annually in arrears on March 15 and September 15 in each year (each, an
“Interest Payment Date”), commencing September 15, 2007, at the rate of 2.00% per annum, until the principal hereof is due, and at the same rate on any overdue principal and, to the extent permitted by law, on any overdue
interest. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date shall, as provided in the Indenture, be paid to the Person in whose name this Note (or one or more Predecessor Notes) is registered at the
close of business on the Regular Record Date for such interest, which shall be the March 1 or September 1 (whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Except as otherwise provided in the
Indenture, any such interest not so punctually paid or duly provided for shall forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Note (or one or more Predecessor Notes) is
registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Company, notice whereof shall be given to Holders of Notes not less than 10 calendar days prior to the Special Record Date, or
be paid at any time in any other lawful manner not inconsistent with the requirements of any automated quotation system or securities exchange on which the Notes may be listed for trading, and upon such notice as may be required by such exchange,
all as more fully provided in the Indenture. Payments of principal shall be made upon the surrender of this Note at the option of the Holder at the Corporate Trust Office of the Trustee, or at such other office or agency of the Company as may be
designated by it for such purpose in such lawful monies of the United States of America as at the time of payment shall be legal tender for the payment of public and private debts, or at such other offices or agencies as the Company may designate,
by United States Dollar check drawn on, or wire transfer to, a United States Dollar account (such a 

  

 17 

 
transfer to be made only to a Holder of an aggregate principal amount of Notes in excess of U.S. $5.0 million and only if such Holder shall have furnished
wire instructions in writing to the Trustee no later than 15 calendar days prior to the relevant payment date). Payment of interest on this Note may be made on an Interest Payment Date by United States Dollar check mailed to the address of the
Person entitled thereto as such address shall appear in the Register, or, upon written application by the Holder to the Registrar setting forth wire instructions not later than the relevant Record Date, by transfer to a United States Dollar account
(such a transfer to be made only to a Holder of an aggregate principal amount of Notes in excess of U.S. $5.0 million and only if such Holder shall have furnished wire instructions in writing to the Trustee no later than 15 calendar days prior to
the relevant payment date). 
 Except as specifically provided herein and in the Indenture, the Company shall not be required to make any
payment with respect to any tax, assessment or other governmental charge imposed by any government or any political subdivision or taxing authority thereof or therein. 
 Reference is hereby made to the further provisions of this Note set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof or an Authenticating Agent by the
manual signature of one of their respective authorized signatories, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 
 [Remainder of page intentionally left blank] 
  

 18 

 IN WITNESS WHEREOF, the Company has caused this Note to be duly executed. 
  

			
	VIROPHARMA INCORPORATED
		
	By:	 	  

	Name:	 	
	Title:	 	

  

			
	 Attest:
	 	
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 
 This is one of the Notes referred to in the within-mentioned Indenture. 
 Dated:
                     
  

			
	 WILMINGTON TRUST COMPANY, as Trustee

		
	By:	 	  

		 	Authorized Signatory

  

 19 

 [FORM OF REVERSE OF NOTE] 
 VIROPHARMA INCORPORATED 
 2.00% Convertible Senior Notes due 2017 
 This Note is one of a duly authorized issue of Notes of the Company designated as its “2.00% Convertible Senior Notes due 2017” (herein
called the “Notes”) issued and to be issued under an Original Indenture dated as of March 19, 2007 and First Supplemental Indenture dated as of March 26, 2007, between the Company and Wilmington Trust Company, as Trustee
(herein called the “Trustee,” which term includes any successor trustee under the Original Indenture and First Supplemental Indenture collectively referred to herein as the “Indenture”), to which the Indenture and
all indentures supplemental thereto reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Notes and of the terms upon which the
Notes are, and are to be, authenticated and delivered. As provided in the Indenture and subject to certain limitations therein set forth, the Notes are exchangeable for a like aggregate principal amount of Notes of any authorized denominations as
requested by the Holder surrendering the same upon surrender of the Note or Notes to be exchanged, at the Corporate Trust Office of the Trustee. The Trustee upon such surrender by the Holder shall issue the new Notes in the requested denominations.
Additional Notes may be issued in an unlimited aggregate principal amount, subject to certain conditions specified in the Indenture. 
 No
sinking fund is provided for the Notes and the Notes are not subject to redemption at the option of the Company. 
 In any case where the due
date for the payment of the principal of or interest on any Note or the last day on which a Holder of a Note has a right to convert his Note shall be, at any Place of Payment or Place of Conversion, as the case may be, a day on which banking
institutions at such Place of Payment or Place of Conversion are authorized or obligated by law or executive order to close, then payment of principal, interest or delivery for conversion of such Note need not be made on or by such date at such
place but may be made on or by the next succeeding day at such place which is not a day on which banking institutions are authorized or obligated by law or executive order to close, with the same force and effect as if made on the date for such
payment or the date fixed for redemption or repurchase, or by such last day for conversion, and no interest shall accrue on the amount so payable for the period after such date. 
 The Indenture contains provisions permitting the Company and the Trustee in certain circumstances, without the consent of the Holders of the Notes, and
in other circumstances, with the consent of the Holders of not less than a majority in aggregate principal amount of the Notes at the time outstanding, 

  

 20 

 
evidenced as in the Indenture provided, to execute supplemental indentures adding any provisions to or changing in any manner or eliminating any of the
provisions of the Indenture or of any supplemental indenture or modifying in any manner the rights of the Holders of the Notes; provided, however, that no such supplemental indenture shall make any of the changes set forth in
Section 8.02 of the First Supplemental Indenture, without the consent of each Holder of an outstanding Note affected thereby. It is also provided in the Indenture that, prior to any declaration accelerating the maturity of the Notes, the
Holders of a majority in aggregate principal amount of the Notes at the time outstanding may on behalf of the Holders of all of the Notes waive any past Default or Event of Default under the Indenture and its consequences except as provided in the
Indenture. Any such consent or waiver by the Holder of this Note (unless revoked as provided in the Indenture) shall be conclusive and binding upon such Holder and upon all future holders and owners of this Note and any Notes which may be issued in
exchange or substitution hereof, irrespective of whether or not any notation thereof is made upon this Note or such other Notes. 
 No
reference herein to the Indenture and no provision of this Note or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, and accrued and unpaid interest on, this Note, at
the place, at the respective times, at the rate and in the lawful money herein prescribed. 
 Subject to the provisions of the Indenture,
upon the occurrence of a Fundamental Change, the Holder has the right, at such Holder’s option, to require the Company to repurchase all of such Holder’s Notes or any portion thereof (in principal amounts of $1,000 or integral multiples
thereof) on the Fundamental Change Repurchase Date at a price equal to 100% of the principal amount of the Notes such Holder elects to require the Company to repurchase, together with accrued and unpaid interest to but excluding the Fundamental
Change Repurchase Date, unless such Fundamental Change Repurchase Date falls after a Regular Record Date and on or prior to the corresponding Interest Payment Date, in which case the Company shall pay the full amount of accrued and unpaid interest
payable on such Interest Payment Date to the Holder of record at the close of business on the corresponding Regular Record Date. The Company or, at the written request of the Company, the Trustee shall mail to all Holders of record of the Notes a
notice of the occurrence of a Fundamental Change and of the repurchase right arising as a result thereof after the occurrence of any Fundamental Change, but on or before the 10th calendar day following such occurrence. 
 Subject to the provisions of the Indenture, the Holder hereof has the right, at its option, on and after December 15, 2016, or earlier upon the
occurrence of certain conditions specified in the Indenture and prior to the close of business on the third Scheduled Trading Day immediately preceding the Maturity Date, to 

  

 21 

 
convert any Notes or portion thereof which is $1,000 or an integral multiple thereof, into shares of Common Stock or Reference Property (or, if the Company
has made the Net Share Settlement Election pursuant to Section 12.02(b) of the First Supplemental Indenture prior to the Conversion Date in respect of this notice, cash and shares of Common Stock or Reference Property, if any), in each case at
the Conversion Rate specified in the Indenture, as adjusted from time to time as provided in the Indenture, upon surrender of this Note, together with a Notice of Conversion, a form of which is contained under Section 2.03 of the First
Supplemental Indenture, as provided in the Indenture and this Note, to the Company at the office or agency of the Company maintained for that purpose, or at the option of such Holder, the Corporate Trust Office, and, unless the shares of Common
Stock or Reference Property, as the case may be, issuable on conversion are to be issued in the same name as this Note, duly endorsed by, or accompanied by instruments of transfer in form satisfactory to the Company or its agent duly executed by,
the Holder or by his duly authorized attorney. The initial Conversion Rate shall be 52.9998 shares of Common Stock for each $1,000 principal amount of Notes. No fractional shares of Common Stock or Reference Property, as the case may be, shall be
issued upon any conversion, but an adjustment in cash shall be paid to the Holder, as provided in the Indenture, in respect of any fraction of such share which would otherwise be issuable upon the surrender of any Note or Notes for conversion. No
adjustment shall be made for dividends or any such shares issued upon conversion of such Notes except as provided in the Indenture. 
 Upon
due presentment for registration of transfer of this Note at the office or agency of the Company, a new Note or Notes of authorized denominations for an equal aggregate principal amount shall be issued to the transferee in exchange thereof, subject
to the limitations provided in the Indenture, without charge except for any tax, assessments or other governmental charge imposed in connection therewith. 
 The Company, the Trustee, any Authenticating Agent, any Paying Agent, any Conversion Agent and any Registrar may deem and treat the registered Holder hereof as the absolute owner of this Note (whether or not this Note
shall be overdue and notwithstanding any notation of ownership or other writing hereon), for the purpose of receiving payment hereof, or on account hereof, for the conversion hereof and for all other purposes, and neither the Company nor the Trustee
nor any authenticating agent nor any Paying Agent nor any Conversion Agent nor any Registrar shall be affected by any notice to the contrary. All payments made to or upon the order of such registered Holder shall, to the extent of the sum or sums
paid, satisfy and discharge liability for monies payable on this Note. 
 No recourse for the payment of the principal of, or accrued and
unpaid interest on, this Note, or for any claim based hereon or otherwise in respect hereof, and no recourse under or upon any obligation, covenant or agreement of the 

  

 22 

 
Company in the Indenture or any indenture supplemental thereto or in any Note, or because of the creation of any Indebtedness represented thereby, shall be
had against any incorporator, stockholder, employee, agent, officer, director or subsidiary, as such, past, present or future, of the Company or of any successor corporation, either directly or through the Company or any successor corporation,
whether by virtue of any constitution, statute or rule of law or by the enforcement of any assessment or penalty or otherwise, all such liability being, by the acceptance hereof and as part of the consideration for the issue hereof, expressly waived
and released. 
 Terms used in this Note and defined in the Indenture are used herein as therein defined. 
 The Indenture and this Note shall be governed by and construed in accordance with the laws of the State of New York. 
 Customary abbreviations may be used in the name of a Holder or an assignee, such as TEN COM (=tenants in common), TENANT (=tenants by the entireties), JT
TEN (joint tenants with right of survivorship and not as tenants in common), CUST (=custodian), and U/G/M/A (=Uniform gift to Minors Act). 
  

 23 

 FORM OF FUNDAMENTAL CHANGE REPURCHASE NOTICE 
 To: ViroPharma Incorporated 
 The undersigned registered
owner of this Note hereby acknowledges receipt of a notice from ViroPharma Incorporated (the “Company”) as to the occurrence of a Fundamental Change with respect to the Company and hereby directs the Company to pay, or cause the
Trustee to pay,                      an amount in cash equal to 100% of the entire principal amount, or the portion thereof (which is $1,000
principal amount or an integral multiple thereof) below designated, to be repurchased plus interest accrued to, but excluding, the Fundamental Change Repurchase Date, except as provided in the Indenture. 
  

			
	Dated:	 	
		
	  
	 	
		
	  
	 	
		
	Signature(s)	 	
		
	Signature(s) must be guaranteed by an Eligible Guarantor Institution with membership in an approved signature guarantee program pursuant to Rule 17Ad-15 under the Securities Exchange Act of
1934.	 	
		
	  
	 	
	Signature Guaranteed	 	
		
	Principal amount to be repurchased (at least U.S. $1,000 or an integral multiple of $1,000 in excess thereof):
                    	 	
		
	Remaining principal amount following such repurchase (not less than U.S. $1,000):
                    	 	

  

			
	 By:
	 	  

		 	Authorized Signatory

  

 24 

 SECTION 2.03. Form of Notice of Conversion. 
 NOTICE OF CONVERSION 
 The undersigned Holder
of this Note hereby irrevocably exercises the option to convert this Note, or any portion of the principal amount hereof (which is U.S. $1,000 or an integral multiple of U.S. $1,000 in excess thereof, provided that the unconverted portion of
such principal amount is U.S. $1,000 or any integral multiple of U.S. $1,000 in excess thereof) below designated, into shares of Common Stock or Reference Property, as applicable (or, if the Company has made the Net Share Settlement Election
pursuant to Section 12.02(b) of the First Supplemental Indenture prior to the Conversion Date in respect of this notice, cash and shares of Common Stock or Reference Property, if any) in accordance with the terms of the Indenture referred to in
this Note, and directs that such shares or such combination of cash and shares, if any, together with a check in payment for any fractional share and any Notes representing any unconverted principal amount hereof, be delivered to and be registered
in the name of the undersigned unless a different name has been indicated below. If shares of Common Stock, Reference Property or Notes are to be registered in the name of a Person other than the undersigned, (a) the undersigned shall pay all
transfer taxes payable with respect thereto and (b) signature(s) must be guaranteed by an Eligible Guarantor Institution with membership in an approved signature guarantee program pursuant to Rule 17Ad-15 under the Securities Exchange Act of
1934. Any amount required to be paid by the undersigned on account of interest accompanies this Note. 
  

							
	Dated:	 	______________	 		  	  

		 		 		  	Signature(s)

  

			
	If shares or Notes are to be registered in the name of a Person other than the Holder, please print such Person’s name and address:	 	
		
	  
	 	
	(Name)	 	
		
	  
	 	
		
	  
	 	
	(Address)	 	
		
	  
	 	
	 Social Security or other Identification
 Number, if
any
	 	

  

 25 

	
	  

	 [Signature Guaranteed]

 If only a portion of the Notes is to be converted, please indicate: 
  

	1.	Principal amount to be converted: U.S. $              

  

	2.	Principal amount and denomination of Notes representing unconverted principal amount to be issued: 

 Amount: U.S. $            Denominations: U.S.
$             
 (U.S. $1,000 or any integral multiple of U.S. $1,000 in excess thereof,
provided that the unconverted portion of such principal amount is U.S. $1,000 or any integral multiple of U.S. $1,000 in excess thereof) 
 SECTION 2.04. Form of Assignment. 
 ASSIGNMENT 
 For value received,                     
hereby sell(s), assign(s) and transfer(s) unto                      (Please insert Social Security or other identifying number of
assignee) the within Note, and hereby irrevocably constitutes and appoints                      as attorney to transfer the said Note on the
books of the Company, with full power of substitution in the premises. 
  

							
	Dated:	 	_____________	  	Signature(s)	  	  

 Signature(s) must be guaranteed by an Eligible Guarantor Institution with membership in an
approved signature guarantee program pursuant to Rule 17Ad-15 under the Securities Exchange Act of 1934. 
  

	
	  

	 Signature Guaranteed

  

 26 

 ARTICLE 3 
 THE NOTES 
 SECTION 3.01. Title And Terms. 
 The Notes shall be known and designated as the “2.00% Convertible Senior Notes due 2017” of the Company. Their Maturity Date shall be
March 15, 2017, and they shall bear interest on their principal amount from March 26, 2007, payable semi-annually in arrears on March 15 and September 15 in each year, commencing September 15, 2007, at the rate of
2.00% per annum until the principal thereof is due; provided, however, that payments shall only be made on a Business Day as provided in Section 16.6 of the Original Indenture. 
 The Company shall pay interest on overdue principal at the rate borne by the Notes, and it shall pay interest on overdue installments of interest at the
same rate to the extent lawful. 
 The principal of and interest on the Notes shall be payable as provided in the form of Notes set forth in
Section 2.02. The Fundamental Change Repurchase Price shall be payable at such place as is identified in the Fundamental Change Repurchase Right Notice given pursuant to Section 14.01(b) (such city in which the identified Paying Agent is
located being herein called a “Place of Payment”). 
 The Notes shall be senior unsecured obligations of the Company and
shall rank pari passu with all of the Company’s other senior unsecured obligations. 
 The Notes may not be redeemed at the
option of the Company prior to Maturity. 
 The Notes shall be convertible as provided in Article 12 (any city in which any Conversion Agent
is located being herein called a “Place of Conversion”). 
 The Notes shall be subject to repurchase by the Company at the
option of the Holders as provided in Article 14. 
 SECTION 3.02. Denominations. The Notes shall be issuable only in registered
form, without coupons, in denominations of U.S. $1,000 and integral multiples of U.S. $1,000 in excess thereof. 
 SECTION 3.03.
Global Notes; Non-Global Notes; Book-entry Provisions. 
 (a) Global Notes 
 (i) Each Global Note authenticated under this First Supplemental Indenture shall be registered in the name of the Depositary designated by
the Company for such Global Note or a nominee thereof 

  

 27 

 
and delivered to such Depositary or a nominee thereof or custodian therefor, and each such Global Note shall constitute a single Note for all purposes of
this First Supplemental Indenture. The Company hereby appoints DTC as the Depositary. 
 (ii) Except for exchanges of Global
Notes for definitive, non-Global Notes at the sole discretion of the Company, no Global Note may be exchanged in whole or in part for Notes registered, and no transfer of a Global Note in whole or in part may be registered, in the name of any Person
other than the Depositary for such Global Note or a nominee thereof unless (A) such Depositary (i) has notified the Company that it is unwilling or unable to continue as Depositary for such Global Note or (ii) has ceased to be a
clearing agency registered as such under the Exchange Act or announces an intention permanently to cease business or does in fact do so or (B) there shall have occurred and be continuing an Event of Default with respect to such Global Note. In
such event, if a successor Depositary for such Global Note is not appointed by the Company within 90 calendar days after the Company receives such notice or becomes aware of such ineligibility, the Company shall execute, and the Trustee, upon
receipt of an Officers’ Certificate directing the authentication and delivery of non-Global Notes, shall authenticate and deliver, non-Global Notes, in any authorized denominations in an aggregate principal amount equal to the principal amount
of such Global Note in exchange for such Global Note. 
 (iii) If any Global Note is to be exchanged for other Notes or
canceled in whole, it shall be surrendered by or on behalf of the Depositary or its nominee to the Trustee, as Registrar, for exchange or cancellation, as provided in this Article 3. If any Global Note is to be exchanged for other Notes or canceled
in part, or if another Note is to be exchanged in whole or in part for a beneficial interest in any Global Note, in each case, as provided in Article III of the Original Indenture, then either (A) such Global Note shall be so surrendered for
exchange or cancellation, as provided in this Article 3, or (B) the principal amount thereof shall be reduced or increased by an amount equal to the portion thereof to be so exchanged or canceled, or equal to the principal amount of such other
Note to be so exchanged for a beneficial interest therein, as the case may be, by means of an appropriate adjustment made on the records of the Trustee, as Registrar, whereupon the Trustee, in accordance with the Applicable Procedures, shall
instruct the Depositary or its authorized representative to make a corresponding adjustment to its records. Upon any such surrender or adjustment of a Global Note, the Trustee shall, subject to this Article 3, authenticate and deliver any Notes
issuable in exchange for such Global Note (or any portion thereof) to or upon the order of, and registered in such names as may be directed by, the 

  

 28 

 
Depositary or its authorized representative. The Trustee shall be entitled to receive from the Depositary the names, addresses and tax identification numbers
of the Persons in whose name the Notes are to be registered prior to such authentication and delivery. Upon the request of the Trustee in connection with the occurrence of any of the events specified in the preceding paragraph, the Company shall
promptly make available to the Trustee a reasonable supply of Notes that are not in the form of Global Notes. The Trustee shall be entitled to rely upon any order, direction or request of the Depositary or its authorized representative which is
given or made pursuant to this Article 3 if such order, direction or request is given or made in accordance with the Applicable Procedures (to the extent such procedures are applicable to such direction or request). 
 (iv) Every Note authenticated and delivered upon registration of transfer of, or in exchange for or in lieu of, a Global Note or any
portion thereof, whether pursuant to this Article 3 or otherwise, shall be authenticated and delivered in the form of, and shall be, a registered Global Note, unless such Note is registered in the name of a Person other than the Depositary for such
Global Note or a nominee thereof, in which case such Note shall be authenticated and delivered in definitive, fully registered form, without interest coupons. 
 (v) The Depositary or its nominee, as registered owner of a Global Note, shall be the Holder of such Global Note for all purposes under
this First Supplemental Indenture and the Notes, and owners of beneficial interests in a Global Note shall hold such interests pursuant to the Applicable Procedures. Accordingly, any such owner’s beneficial interest in a Global Note shall be
shown only on, and the transfer of such interest shall be effected only through, records maintained by the Depositary or its nominee or its Agent Members and such owners of beneficial interests in a Global Note shall not be considered the owners or
holders thereof. 
 (b) Non-Global Notes. Notes issued upon the events described in Section 3.03(a)(ii) shall be in definitive, fully
registered form, without interest coupons. 
 SECTION 3.04. Persons Deemed Owners. 
 Prior to due presentment of a Note for registration of transfer, the Company, the Trustee, any Paying Agent and any agent of the Company, the Trustee or
any Paying Agent may treat the Person in whose name such Note is registered as the owner of such Note for the purpose of receiving payment of principal of and (subject to Section 3.8 of the Original Indenture) interest on such Note and for all
other purposes whatsoever, whether or not such Note be overdue, 

  

 29 

 
and neither the Company, the Trustee, any Paying Agent nor any agent of the Company, the Trustee or any Paying Agent shall be affected by notice to the
contrary. 
 ARTICLE 4 
 SATISFACTION AND DISCHARGE 
 SECTION 4.01. Satisfaction And Discharge Of
Indenture. 
 Section 12.2 of the Original Indenture shall not be applicable to the Notes. 
 ARTICLE 5 
 REMEDIES 

SECTION 5.01. Events Of Default. 
 Section 7.1 of the Original Indenture shall not be applicable to the Notes. 
 “Event of Default,” wherever
used herein, means any one of the following events with respect to the Notes (whatever the reason for such Event of Default or whether it shall be voluntary or involuntary or be effected by operation of law or pursuant to any judgment, decree or
order of any court or any order, rule or regulation of any administrative or governmental body): 
 (a) default in any payment of interest on
any Note when due and payable and the default continues for a period of 30 calendar days; or 
 (b) default in the payment of principal of
any Note when due and payable at Maturity, upon required repurchase, upon acceleration or otherwise; or 
 (c) failure by the Company to
comply with its obligation to convert the Notes into shares of Common Stock or units of Reference Property or, cash and shares or units, if any, of Common Stock or Reference Property, as applicable, upon exercise of a Holder’s conversion right;
or 
 (d) failure by the Company to comply with its obligations under Section 6.4 of the Original Indenture; or 
 (e) failure by the Company to issue a Fundamental Change Repurchase Right Notice in accordance with Section 14.01 or comply with its notice
requirements under Sections 12.01(b)-(e) when due; or 
  

 30 

 (f) failure by the Company for 60 calendar days to comply with any of its other agreements (other than a
covenant or warranty Default in whose performance or whose breach is elsewhere in this Section 5.01 specifically provided for) contained in the Notes or this First Supplemental Indenture after written notice of such Default from the Trustee or
the Holders of at least 25% principal amount of the Outstanding Notes has been received by the Company; or 
 (g) default by the Company or
any Subsidiary of the Company with respect to any mortgage, agreement or other instrument under which there may be outstanding, or by which there may be secured or evidenced, any debt for money borrowed in excess of $15.0 million in the aggregate of
the Company and/or any such Subsidiary, whether such debt now exists or shall hereafter be created, which default results (i) in such debt becoming or being declared due and payable, and such debt shall not have been discharged in full or such
declaration rescinded or annulled within 30 calendar days or (ii) from a failure to pay the principal of any such debt when due and payable at its stated maturity, upon required repurchase, upon declaration or otherwise, and such defaulted
payment shall not have been made, waived or extended within 30 calendar days; or 
 (h) failure by the Company or any of its Subsidiaries,
within 60 calendar days, to pay, bond or otherwise discharge any judgments or orders for the payment of money the total uninsured amount of which for the Company or any of its Subsidiaries exceeds in the aggregate $15.0 million, which are not stayed
on appeal; or 
 (i) the Company or any of its Significant Subsidiaries shall commence a voluntary case or other proceeding seeking
liquidation, reorganization or other relief with respect to itself or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or seeking the appointment of a trustee, receiver, liquidator, custodian or other
similar official of the Company or any of its Significant Subsidiaries or any substantial part of its respective property, or shall consent to any such relief or to the appointment of or taking possession by any such official in an involuntary case
or other proceeding commenced against it, or shall make a general assignment for the benefit of creditors, or shall fail generally to pay its debts as they become due; or 
 (j) an involuntary case or other proceeding shall be commenced against the Company or any of its Significant Subsidiaries seeking liquidation, reorganization or other relief with respect to it or its debts under any
bankruptcy, insolvency or other similar law now or hereafter in effect or seeking the appointment of a trustee, receiver, liquidator, custodian or other similar official of the Company or any of its Significant Subsidiaries or any substantial part
of its respective property, and such involuntary case or other proceeding shall remain undismissed and unstayed for a period of sixty (60) consecutive calendar days. 
  

 31 

 SECTION 5.02. Acceleration Of Maturity; Rescission And Annulment. 
 Section 7.2 of the Original Indenture shall not be applicable to the Notes. 
 If an Event of Default (other than an Event of Default specified in Section 5.01(i) or Section 5.01(j) with respect to the Company) occurs and
is continuing, then in every such case (except as provided in the immediately following paragraph) the Trustee or the Holders of not less than 25% in principal amount of the Outstanding Notes may declare the principal of and accrued and unpaid
interest on all such Notes to be due and payable immediately, by a notice in writing to the Company (and to the Trustee if given by the Holders), and upon any such declaration of acceleration, all principal and all accrued interest on the Notes
shall become immediately due and payable. If an Event of Default specified in Section 5.01(i) or Section 5.01(j) with respect to the Company occurs, the principal of, and accrued interest on, all of the Notes shall become immediately due
and payable without any declaration or other Act of the Holders or any act on the part of the Trustee. 
 Notwithstanding the foregoing, at
the election of the Company, the sole remedy for an Event of Default specified in Section 5.01(f) relating to the failure by the Company to comply with its obligations under Section 9.02 and for any failure by the Company to comply with
the requirements of Section 314(a)(1) of the Trust Indenture Act, shall for the first 60 calendar days after the occurrence of such an Event of Default consist exclusively of the right (the “Extension Right”) to receive an
extension fee on the Notes in an amount equal to 0.25% of the principal amount of the Notes (the “Extension Fee”). If the Company so elects, the Extension Fee shall be payable on all Outstanding Notes the date on which an Event of
Default relating to a failure to comply with the obligations under Section 9.02 or the failure to comply with the requirements of Section 314(a)(1) of the Trust Indenture Act first occurs. If such Event of Default has not been cured or
waived pursuant to Section 5.04 prior to such 60th calendar day, then the Trustee or the Holders of not less than 25% in principal amount of the Outstanding Notes may declare the principal of and accrued and unpaid interest on all such Notes to
be due and payable immediately. If the Company elects to pay the Extension Fee as the sole remedy for an Event of Default specified in Section 5.01(f) relating to the failure by the Company to comply with its obligations under Section 9.02
and for any failure by the Company to comply with the requirements of Section 314(a)(1) of the Trust Indenture Act, the Company shall notify, in the manner provided for in Section 16.5 of the Original Indenture, the Holders, the Paying
Agent and the Trustee of such election at any time on or before the close of business on the date on which such Event of Default first occurs. If the Company fails to give timely notice or pay the Extension Fee, then the Trustee or the Holders of
not less than 25% in principal amount of the outstanding Notes may declare the principal of and accrued and unpaid interest on all such Notes to be due and payable immediately. If an Extension Fee is payable under this Section 

  

 32 

 
5.02, the Company shall deliver to the Trustee a certificate to that effect stating (i) the amount of such Extension Fee that is payable and
(ii) the date on which such Extension Fee is payable. Unless and until a Responsible Officer of the Trustee receives at the Corporate Trust Office such a certificate, the Trustee may assume without inquiry that the Extension Fee is not payable.
If the Extension Fee has been paid by the Company directly to the persons entitled to it, the Company shall deliver to the Trustee a certificate setting forth the particulars of such payment. 
 Notwithstanding the foregoing paragraph, if an Event of Default occurs under any series of the Company’s debt securities (other than the Notes)
issued subsequent to the Issue Date resulting from the Company’s failure to comply with obligations similar to those contained in Section 9.02 or the requirements of Section 314(a)(1) of the Trust Indenture Act, and such Event of
Default is not subject to extension on terms similar to those set forth in the foregoing paragraph, then the Extension Right shall no longer apply and the Notes shall be subject to acceleration as provided in the first paragraph of this
Section 5.02. 
 This Section 5.02, however, is subject to the conditions that if, at any time after the principal of the Notes
shall have been so declared due and payable, and before any judgment or decree for the payment of the monies due shall have been obtained or entered as hereinafter provided, the Company shall pay or shall deposit with the Trustee a sum sufficient to
pay installments of accrued and unpaid interest upon all Notes and the principal of any and all Notes that shall have become due otherwise than by acceleration (with interest on overdue installments of accrued and unpaid interest (to the extent that
payment of such interest is enforceable under applicable law) and on such principal at the rate borne by the Notes during the period of such Default) and amounts due to the Trustee pursuant to Section 11.1 of the Original Indenture, and if
(1) rescission would not conflict with any judgment or decree of a court of competent jurisdiction and (2) any and all Events of Default under this First Supplemental Indenture with respect to such Notes, other than the nonpayment of
principal of and accrued and unpaid interest on such Notes that shall have become due solely by such acceleration, shall have been cured or waived pursuant to Section 5.04, then and in every such case the Holders of a majority in aggregate
principal amount of the Outstanding Notes, by written notice to the Company and to the Trustee, may waive all Defaults or Events of Default with respect to the Notes and rescind and annul such declaration and its consequences and such Default shall
cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured for every purpose of this First Supplemental Indenture; but no such waiver or rescission and annulment shall extend to or shall affect any subsequent
Default or Event of Default, or shall impair any right consequent thereon. The Company shall notify the Trustee in writing, promptly upon becoming aware thereof, of any Event of Default by delivering to the Trustee a statement specifying such Event
of Default and any action the Company has taken, is taking or proposes to take with respect thereto. No rescission or annulment 

  

 33 

 
referred to above shall affect any subsequent Default or impair any right consequent thereon. 
 SECTION 5.03. Unconditional Right Of Holders To Receive Principal And Interest And To Convert. 
 Notwithstanding any other provision in this First Supplemental Indenture, the Holder of any Note shall have the right, which is absolute and
unconditional, to receive payment of the principal of and (subject to Section 3.8 of the Original Indenture) interest on such Note on the Maturity Date, and to convert such Note in accordance with Article 12, and to institute suit for the
enforcement of any such payment and right to convert, and such rights shall not be impaired without the consent of such Holder. 
 SECTION
5.04. Waiver Of Past Defaults. 
 The Holders of not less than a majority in principal amount of the Outstanding Notes may on
behalf of the Holders of all of the Notes waive any past Default hereunder and its consequences, except a Default (A) in the payment of the principal of or interest on any Note or the failure to deliver shares of Common Stock (or, if the
Company has made the Net Share Settlement Election, cash and shares, if any, of Common Stock) due upon conversion of any Note, or (B) in respect of a covenant or provision hereof which under Article 8 cannot be modified or amended without the
consent of the Holder of each Outstanding Note affected. 
 Upon any such waiver, such Default shall cease to exist, and any Event of Default
arising therefrom shall be deemed to have been cured, for every purpose of this First Supplemental Indenture; but no such waiver shall extend to any subsequent or other Default or impair any right consequent thereon. 
 SECTION 5.05. Waiver Of Stay, Usury Or Extension Laws. 
 The Company covenants (to the extent that it may lawfully do so) that it shall not at any time insist upon, or plead, or in any manner whatsoever claim or
take the benefit or advantage of, any stay, usury or extension law wherever enacted, now or at any time hereafter in force, that may affect the covenants or the performance of this First Supplemental Indenture; and the Company (to the extent that it
may lawfully do so) hereby expressly waives all benefit or advantage of any such law and covenants that it shall not hinder, delay or impede by reason of such law the execution of any power herein granted to the Trustee, but shall suffer and permit
the execution of every such power as though no such law had been enacted. 
  

 34 

 ARTICLE 6 
 [RESERVED] 
 ARTICLE 7 
 [RESERVED] 
 ARTICLE 8 
 SUPPLEMENTAL INDENTURES 
 SECTION 8.01. Supplemental Indentures Without Consent Of Holders Of Notes. 
 Section 14.1 of the Original
Indenture shall not be applicable to the Notes. 
 Without the consent of any Holders of Notes, the Company, when authorized by a Board
Resolution, and the Trustee, upon receipt of a Company Request, at any time and from time to time, may enter into one or more indentures supplemental hereto for any of the following purposes: 
 (a) (x) to cure any ambiguity, manifest error or defect or (y) to cure any omission or inconsistency; provided that, in the case of clause
(y) only if the rights of the Holders are not adversely affected in any material respect; or 
 (b) to evidence the succession of
another Person to the Company and the assumption by any such successor of the covenants and obligations of the Company herein and in the Notes as permitted by Section 6.4 of the Original Indenture; or 
 (c) to add guarantees with respect to the Notes; or 
 (d) to secure the Notes; or 
 (e) to add to the covenants of the Company or Events of Default for the benefit of the Holders of
Notes or to surrender any right or power herein conferred upon the Company; or 
 (f) to provide for the conversion of Notes pursuant to
Section 12.10; or 
 (g) to make any changes or modifications to this First Supplemental Indenture, provided that such action
pursuant to this clause (g) shall not adversely affect the rights of the Holders of Notes in any material respect; provided further that any such action to conform the terms of this First Supplemental Indenture or 

  

 35 

 
the Notes to the description of the Notes contained in the Prospectus Supplement shall not be deemed to be adverse to the Holders of Notes; or 
 (h) to comply with the requirements of the Trust Indenture Act or the rules and regulations of the SEC thereunder in order to effect or maintain the
qualification of the Original Indenture and this First Supplemental Indenture under the Trust Indenture Act, as contemplated by this First Supplemental Indenture or otherwise; or 
 (i) to evidence and provide for the acceptance of appointment of a successor Trustee; or 
 (j) to provide for the issuance of Additional Notes in accordance with the terms and conditions of this First Supplemental Indenture; or 
 (k) to make any other provisions with respect to matters or questions arising under this First Supplemental Indenture as the Company may deem necessary
or desirable, provided that such action pursuant to this clause (k) shall not adversely affect the interests of the Holders of Notes in any material respect. 
 Upon Company Request, accompanied by a Board Resolution authorizing the execution of any such supplemental indenture, and subject to and upon receipt by the Trustee of the documents described in Section 14.4 of
the Original Indenture, the Trustee shall join with the Company in the execution of any supplemental indenture authorized or permitted by the terms of this First Supplemental Indenture and to make any further appropriate agreements and stipulations
that may be therein contained. 
 SECTION 8.02. Supplemental Indentures With Consent Of Holders Of Notes. 
 Section 14.2 of the Original Indenture shall not be applicable to the Notes. 
 With the written consent of the Holders of not less than a majority in principal amount of the Outstanding Notes (including without limitation, consents
obtained in connection with a purchase of, or tender offer or exchange offer for Notes), by the Act of said Holders delivered to the Company and the Trustee, the Company, when authorized by a Board Resolution, and the Trustee may enter into an
indenture or indentures supplemental hereto for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of this First Supplemental Indenture or of modifying in any manner the rights of the Holders of
Notes under this First Supplemental Indenture; provided, however, that no such supplemental indenture shall, without the consent of the Holder of each Outstanding Note affected thereby: 
  

 36 

 (a) reduce the percentage in aggregate principal amount of Notes the Holders of which must consent to an
amendment; or 
 (b) reduce the rate, extend the stated time for payment, of interest on any Note or reduce the amount, or extend the stated
time for payment of the Extension Fee; or 
 (c) reduce the principal, or extend the Maturity Date, of any Note; or 
 (d) make any change that adversely affects the conversion rights of any Notes; or 
 (e) reduce the Fundamental Change Repurchase Price of any Note or amend or modify in any manner adverse to the Holders of the Notes the Company’s
obligations to make such payments, whether through an amendment or waiver of provisions in the covenants, definitions or otherwise; or 
 (f)
change the place or currency of payment of principal, interest or the Extension Fee in respect of any Note; or 
 (g) impair the right of any
Holder to receive payment of principal of, and interest on, such Holder’s Notes on or after the due dates therefor or to institute suit for the enforcement of any payment on or with respect to such Holder’s Note; or 
 (h) adversely affect the ranking of the Notes as the senior unsecured Indebtedness of the Company; or 
 (i) make any change in the provisions of this Article 8 that require each Holder’s consent or in the waiver provisions in Section 5.02 and
Section 5.04. 
 It shall not be necessary for any Act of Holders of Notes under this Section 8.02 to approve the particular form
of any proposed supplemental indenture, but it shall be sufficient if such Act shall approve the substance thereof. 
 SECTION 8.03.
Notice Of Supplemental Indentures. 
 Promptly after the execution by the Company and the Trustee of any supplemental indenture
pursuant to the provisions of Section 8.02, the Company shall give notice to all Holders of Notes of such fact, setting forth in general terms the substance of such supplemental indenture, in the manner provided in Section 16.5 of the
Original Indenture. Any failure of the Company to give such notice, or any defect therein, shall not in any way impair or affect the validity of any such supplemental indenture. 
  

 37 

 ARTICLE 9 
 HOLDERS LISTS AND BY TRUSTEE AND COMPANY 
 SECTION 9.01. Preservation Of Information. 
 (a) The Trustee shall preserve, in as current a form as is reasonably practicable, the names and addresses of Holders contained in the most recent list furnished to the Trustee as provided in Section 10.3 of the
Original Indenture and the names and addresses of Holders received by the Trustee in its capacity as Registrar. The Trustee may destroy any list, if any, furnished to it as provided in Section 10.3 of the Original Indenture upon receipt of a
new list so furnished. 
 (b) The rights of Holders to communicate with other Holders with respect to their rights under this First
Supplemental Indenture or under the Notes, and the corresponding rights, and duties of the Trustee, shall be as provided by the Trust Indenture Act. 
 (c) Every Holder of Notes, by receiving and holding the same, agrees with the Company and the Trustee that neither the Company nor the Trustee nor any agent of either of them shall be held accountable by reason of any
disclosure of information as to names and addresses of Holders made pursuant to the Trust Indenture Act. 
 SECTION 9.02. Reports
By Company. 
 (a) The Company shall file any documents that it is required to file with the SEC pursuant to Section 13 or 15(d) of
the Exchange Act with the Trustee within 15 calendar days after the same are required to be filed with the SEC. 
 (b) Delivery of such
reports, information and documents to the Trustee is for informational purposes only, and the Trustee’s receipt of such shall not constitute constructive notice of any information contained therein or determinable from information contained
therein, including the Company’s compliance with any of its covenants hereunder (as to which the Trustee is entitled to conclusively rely exclusively on an Officers’ Certificate). 
 ARTICLE 10 
 COVENANTS 
 SECTION 10.01. Payment Of Principal And Interest. 
 The Company covenants and agrees that it shall duly and punctually pay the principal of and interest on the Notes in accordance with the terms of the Notes and this First Supplemental Indenture. The Company shall
deposit or cause 

  

 38 

 
to be deposited with the Trustee or its nominee, no later than 9:00 a.m., New York City time, on the Maturity Date of the Notes or no later than 9:00 a.m.,
New York City time, on the due date for any installment of interest, all payments so due, which payments shall be in immediately available funds on the date of such Maturity Date or due date, as the case may be. 
 SECTION 10.02. Maintenance Of Offices Or Agencies. 
 The Company shall maintain an office or agency where the Notes may be surrendered for registration of transfer or exchange or for presentation for payment or for conversion or repurchase and where notices and demands
to or upon the Company in respect of the Notes and this First Supplemental Indenture may be served. The Company shall give prompt written notice to the Trustee of the location, and any change in the location, of such office or agency not designated
or appointed by the Trustee. If at any time the Company shall fail to maintain any such required office or agency or shall fail to furnish the Trustee with the address thereof, such presentations, surrenders, notices and demands may be made or
served at the Corporate Trust Office. 
 The Company may at any time and from time to time vary or terminate the appointment of any such
agent or appoint any additional agents for any or all of such purposes; provided, however, that until all of the Notes have been delivered to the Trustee for cancellation, or moneys sufficient to pay the principal of and interest on
the Notes have been made available for payment and either paid or returned to the Company pursuant to the provisions of Section 6.3 of the Original Indenture, the Company shall maintain an office or agency where Notes may be presented or
surrendered for payment and conversion, where Notes may be surrendered for registration of transfer or exchange and where notices and demands to or upon the Company in respect of the Notes and this First Supplemental Indenture may be served. The
Company shall give prompt written notice to the Trustee, and notice to the Holders in accordance with Section 16.5 of the Original Indenture, of the appointment or termination of any such agents and of the location and any change in the
location of any such office or agency. 
 The Company hereby initially designates the Trustee as Paying Agent, Registrar, and Conversion
Agent, and each of the Corporate Trust Office of the Trustee and the office or agency of the Trustee located at Rodney Square North, 1100 North Market Street, Wilmington, Delaware 19890, Attention: Corporate Client Services (ViroPharma
Incorporated), as one such office or agency of the Company for each of the aforesaid purposes. 
 SECTION 10.03. Existence.

 Subject to Section 6.4 of the Original Indenture, the Company shall do or cause to be done all things necessary to preserve and keep
in full force and effect 

  

 39 

 
its existence, rights (charter and statutory) and franchises; provided, however, that the Company shall not be required to preserve any such
right or franchise if the Company shall determine that the preservation thereof is no longer desirable in the conduct of the business of the Company and that the loss thereof is not disadvantageous in any material respect to the Holders. 

SECTION 10.04. Statement By Officers As To Default. 
 Section 6.7 of the Original Indenture shall not be applicable to the Notes. 
 The Company shall deliver
to the Trustee, within 120 calendar days after the end of each fiscal year, an Officers’ Certificate indicating whether the signing officers know of any Default that occurred during the previous fiscal year. The Company shall also deliver to
the Trustee, within 30 calendar days of becoming aware of any Default or any Event of Default under this First Supplemental Indenture, an Officers’ Certificate specifying with particularity such Default or Event of Default, the status of such
Default or Event of Default and further stating what action the Company has taken, is taking or proposes to take with respect thereto. 
 Any
notice required to be given under this Section 10.04 shall be delivered to the Trustee at its Corporate Trust Office. 
 ARTICLE 11

 [RESERVED] 
 ARTICLE 12 
 CONVERSION OF NOTES 
 SECTION 12.01. Conversion Privilege And Conversion Rate. 
 (a) Subject to the conditions described in clause (i), (ii), and (iii) below, and upon compliance with the provisions of this Article 12, a Holder shall have the right, at such Holder’s option, to convert
all or any portion (if the portion to be converted is $1,000 principal amount or an integral multiple thereof) of such Note at any time prior to the close of business on the Scheduled Trading Day immediately preceding December 15, 2016, at a
rate (the “Conversion Rate”) of 52.9998 shares of Common Stock (subject to adjustment by the Company as provided in Section 12.04 and Section 12.01(f)) per $1,000 principal amount of the Note (the “Conversion
Obligation”) under the circumstances and during the periods set forth below. On and after December 15, 2016, regardless of the conditions described in clause (i), (ii) and (iii) below, and upon compliance with the provisions
of this Article 12, a Holder shall have the right, at such Holder’s 

  

 40 

 
option, to convert all or any portion (if the portion to be converted is $1,000 principal amount or an integral multiple thereof) of Notes at the applicable
Conversion Rate at any time prior to the close of business on the third Scheduled Trading Day immediately preceding the Maturity Date. 
 (i) The Notes shall be convertible prior to December 15, 2016, during the five Business Day period immediately after any five consecutive Trading Day period (the “Measurement Period”) in which
the Trading Price per $1,000 principal amount of the Notes for each Trading Day of such Measurement Period was less than 98% of the product of the Last Reported Sale Price of the Common Stock on such Trading Day and the applicable Conversion Rate in
effect on such Trading Day (the “Trading Price Condition”) determined as set forth below. If a Holder provides the Company with reasonable evidence that the Trading Price of the Notes would be less than 98% of the product of
(a) the then-applicable Conversion Rate of the Notes and (b) the Last Reported Sale Price at such time, then the Company shall instruct the Trustee to determine the Trading Price of the Notes beginning on the next Trading Day and on each
successive Trading Day until the date on which the Trading Price per Note is greater than or equal to 98% of the product of (a) the then-applicable Conversion Rate of the Notes and (b) the Last Reported Sale Price (as provided to the
Trustee by the Company on each such date). If the Trading Price Condition has been met, the Company shall so promptly notify the Holders of the Notes. If, at any time after the Trading Price Condition has been met, the Trading Price per $1,000
principal amount of the Notes is greater than 98% of the product of (a) the then-applicable Conversion Rate of the Notes and (b) the Last Reported Sale Price on such date, the Company shall so promptly notify the Holders of the Notes, and
the Trustee shall have no further obligation to determine the Trading Price of the Notes unless requested by the Company to do so again in writing pursuant to this Section 12.01(a)(i). Notwithstanding the foregoing, if the Trustee cannot
reasonably obtain at least one bid for $2.0 million principal amount of the Notes from a nationally recognized securities dealer selected by the Board of Directors of the Company for the purpose of the determining the Trading Price on any Trading
Day, then the Trading Price per $1,000 principal amount of notes shall be deemed to be less than 98% of the product of (a) the then-applicable Conversion Rate of the Notes and (b) the Last Reported Sale Price on such date (any such
determination by the Trustee shall be conclusive absent manifest error). Furthermore, if the Company does not, when obligated to do so pursuant to this clause (i), instruct the Trustee to determine the Trading Price of the Notes, or if the Company
so instructs the Trustee, but the Trustee does not make such determination, then the Trading Price per $1,000 principal amount of the Notes shall be deemed to be less than 98% of the product of 

  

 41 

 
(a) the then-applicable Conversion Rate of the Notes and (b) the Last Reported Sale Price on such date. 
 (ii) The Notes shall be convertible prior to December 15, 2016, during any calendar quarter after the calendar quarter ending
June 30, 2007 (and only during such calendar quarter), if the Last Reported Sale Price of the Common Stock for twenty (20) or more Trading Days in a period of thirty (30) consecutive Trading Days ending on the last Trading Day of the
immediately preceding calendar quarter exceeds 130% of the applicable Conversion Price in effect on the last Trading Day of the immediately preceding calendar quarter. 
 (iii) The Notes shall be convertible prior to December 15, 2016, as provided in subsections (b), (c) and (d) of this
Section 12.01. 
 (b) In the event that the Company elects to: 
 (i) distribute to all or substantially all holders of Common Stock any rights or warrants entitling them, for a period of not more than 45
calendar days after the record date for such distribution, to subscribe for or purchase Common Stock at a price per share less than the Last Reported Sale Price of the Common Stock for the Trading Day immediately preceding the declaration date of
such distribution; or 
 (ii) distribute to all or substantially all holders of Common Stock, assets (including cash) or debt
securities of the Company or rights to purchase the Company’s securities, which distribution has a per share value (as determined by the Board of Directors) exceeding 15% of the Last Reported Sale Price of the Common Stock on the Trading Day
immediately preceding the date of declaration of such distribution, 
 then, in either case, Holders may surrender the Notes for conversion at any time on
and after the date that the Company provides the notice to such Holders and the Trustee referred to in the next sentence until the earlier of 5:00 p.m., New York City time, on the Business Day immediately preceding the Ex-Date for such distribution
or the date the Company announces that such distribution will not take place. The Company shall notify Holders and the Trustee of any distribution referred to in either clause (i) or clause (ii) above and of the resulting conversion right
no later than the 30th Scheduled Trading Day prior to the Ex-Date for such distribution. A Holder may not exercise this right if such Holder is permitted to participate (as a result of holding the Notes, and at the same time as holders of the Common
Stock participate) in any distribution referred to in clause (i) or clause (ii) above as if such Holder held a number of shares of Common Stock equal to the then-applicable Conversion Rate, multiplied by the principal amount 

  

 42 

 
(expressed in thousands) of Notes held by such Holder, without having to convert its Notes. 
 (c) If the Company is a party to a combination, merger, recapitalization, reclassification, binding share exchange or other similar transaction or sale
or conveyance of all or substantially all of its properties and assets, in each case pursuant to which the Common Stock would be converted into cash, securities and/or other property, then the Holders shall have the right to convert Notes at any
time beginning 30 Scheduled Trading Days prior to the date announced by the Company as the anticipated effective date of the transaction and until and including the date that is 30 Scheduled Trading Days after the date that is the effective date of
such transaction; provided such transaction does not otherwise constitute a Fundamental Change to which the provisions of subsections (d) and (e) of this Section shall apply. The Company shall notify Holders and the Trustee and
issue a Press Release at least 30 Scheduled Trading Days prior to the anticipated effective date of such transaction. The Board of Directors shall determine the anticipated effective date of the transaction, and such determination shall be
conclusive and binding on the Holders. 
 (d) If the Company is a party to any transaction or event that is described in clause (2) of
the definition of Fundamental Change, a Holder may surrender Notes for conversion at any time, after the Company gives the notice referred to in following sentence, from and after the 30th Scheduled Trading Day prior to the anticipated Effective
Date of such transaction or event until (i) the related Fundamental Change Repurchase Date for such transaction or event or (ii) if there is no such Fundamental Change Repurchase Date, 30 Scheduled Trading Days following the Effective Date
of such Fundamental Change. The Company shall notify, in the manner provided for in Section 16.5 of the Original Indenture, each of the Holders and the Trustee of such event or transaction, and issue a Press Release, no later than 30 Scheduled
Trading Days prior to the anticipated Effective Date of such event or transaction. 
 (e) If an event or transaction described in clauses
(1), (3), (4) and (5) of the definition of Fundamental Change occurs, the Company shall notify, in the manner provided in Section 16.5 of the Original Indenture, each of the Holders and the Trustee of the occurrence of any such event
or transaction on the Effective Date of such event or transaction. A Holder may surrender Notes for conversion at any time, after the Company gives the notice referred to in the preceding sentence, from and after the Effective Date of such event or
transaction until (i) the Fundamental Change Repurchase Date for such event or transaction or (ii) if there is no such Fundamental Change Repurchase Date, 30 Scheduled Trading Days following the Effective Date of such Fundamental Change.

 (f) If a Holder elects to convert Notes in connection with a Fundamental Change described in clauses (1), (2) and (4) of the
definition of 

  

 43 

 
Fundamental Change that occurs prior to the Maturity Date, the Conversion Rate applicable to each $1,000 principal amount of Notes so converted shall be
increased by an additional number of shares of Common Stock (the “Additional Shares”) as described below; provided, however that no increase shall be made in the case of a Fundamental Change described in clauses
(1) or (2) of the definition of Fundamental Change if at least 90% of the consideration paid for the Company’s Common Stock (excluding cash payments for fractional shares and cash payments made pursuant to dissenters’ appraisal
rights) in such Fundamental Change transaction consists of shares of Capital Stock or American Depositary Receipts in respect of shares of Capital Stock traded on any of the New York Stock Exchange, the American Stock Exchange, the NASDAQ Global
Select Market or the NASDAQ Global Market (or any of their respective successors) (or that will be so traded immediately following the transaction) and as a result of such transaction or transactions the Notes become convertible into shares of such
Capital Stock or such American Depositary Receipts (or, if the Company has made the Net Share Settlement Election, into cash (in respect of the principal portion of the Notes) and, if applicable, such shares of such Capital Stock or such American
Depositary Receipts). Settlement of Notes tendered for conversion to which Additional Shares shall be added to the Conversion Rate as provided in this subsection shall be settled pursuant to Section 12.02(f). For purposes of this subsection
(f), a conversion shall be deemed to be “in connection with” a Fundamental Change to the extent that a Holder surrenders Notes for conversion (x) on or after the 30th Scheduled Trading Day prior to the anticipated Effective
Date of such Fundamental Change described in clause (2) of the definition of Fundamental Change or (y) on or after the Effective Date of such Fundamental Change described in clauses (1) or (4) of the definition of Fundamental
Change, in each case until the related Fundamental Change Repurchase Date for such Fundamental Change (or, if there is no such Fundamental Change Repurchase Date, until the 30th Scheduled Trading Day following such Effective Date) (regardless of
whether the provisions of clause (a)(i), (a)(ii), (b) or (c) of this Section shall apply to such conversion). 
 (i)
The number of Additional Shares shall be determined by the Company by reference to the table attached as Schedule A hereto, based on the date on which the Fundamental Change occurs or becomes effective (the “Effective Date”), and
the Stock Price; provided that if the actual Stock Price is between two Stock Price amounts in the table or the Effective Date is between two Effective Dates in the table, the number of Additional Shares shall be determined by a straight-line
interpolation between the number of Additional Shares set forth for the next higher and next lower Stock Price amounts and the two nearest Effective Dates, as applicable, based on a 365-day year; provided further that if (1) the Stock
Price is greater than $150.00 per share of Common Stock (subject to adjustment in the same manner as set forth in Section 12.04), no 

  

 44 

 
Additional Shares shall be added to the Conversion Rate, and (2) the Stock Price is less than $14.24 per share (subject to adjustment in the same manner
as set forth in Section 12.04), no Additional Shares shall be added to the Conversion Rate. Notwithstanding the foregoing, in no event shall the Conversion Rate exceed 70.2247 per $1,000 principal amount of Notes (subject to adjustment in
the same manner as set forth in Section 12.04). 
 (ii) The Stock Prices set forth in the first row of the tables in
Schedule A hereto shall be adjusted by the Company as of any date on which the Conversion Rate of the Notes is adjusted. The adjusted Stock Prices shall equal the Stock Prices applicable immediately prior to such adjustment, multiplied by a
fraction, the numerator of which is the applicable Conversion Rate in effect immediately prior to the adjustment giving rise to the Stock Price adjustment and the denominator of which is the Conversion Rate as so adjusted. The number of Additional
Shares within the table shall be adjusted in the same manner as the Conversion Rate as set forth in Section 12.04 (other than by operation of an adjustment to the Conversion Rate by adding Additional Shares). 
 Section 12.02. Exercise Of Conversion Privilege. 
 (a) Subject to subsections (b) and (c) below, the Company shall satisfy the Conversion Obligation with respect to each $1,000 principal amount of Notes tendered for conversion in shares of fully paid Common
Stock by delivering on the third VWAP Trading Day after the relevant Conversion Date (or, with respect to any Conversion Date occurring on or after the 30th Scheduled Trading Day prior to the Maturity Date, on the third VWAP Trading Day following
the last VWAP Trading Day of the Final Observation Period) a number of shares of Common Stock equal to (i) (A) the aggregate principal amount of Notes to be converted, divided by (B) 1,000, multiplied by (ii) the Conversion Rate
in effect on the relevant Conversion Date; provided that the Company will deliver cash in lieu of fractional shares of Common Stock based on the Last Reported Sale Price of the Common Stock on the relevant Conversion Date (or, if the
Conversion Date is not on a Trading Day, the next following Trading Day) (or, with respect to any Conversion Date occurring on or after the 30th Scheduled Trading Day prior to the Maturity Date, on the last VWAP Trading Day of the Final Observation
Period) as provided in Section 12.03. 
 (b) (i) Subject to subsection (c) below, at any time on or prior to the 35th Scheduled
Trading Day prior to the Maturity Date, the Company may irrevocably elect to satisfy the Conversion Obligation with respect to each $1,000 principal amount of Notes tendered for conversion for which the Conversion Date occurs after the Company
issues the Press Release referred to in subsection (b)(ii) below in cash and shares of fully paid Common Stock, if applicable, by delivering, on the third VWAP Trading Day immediately following the last VWAP Trading 

  

 45 

 
Day of the related Observation Period, cash and shares of Common Stock, if any, equal to the sum of the Daily Settlement Amounts for each of the 25 VWAP
Trading Days during the related Observation Period (the “Net Share Settlement Election”); provided that the Company shall deliver cash in lieu of fractional shares of Common Stock as provided in Section 12.03. The Daily
Settlement Amounts shall be determined by the Company promptly following the last VWAP Trading Day of the Observation Period. 
 (ii) If the
Company makes the Net Share Settlement Election, the Company will promptly (x) issue a Press Release (and the Net Share Settlement Election will become effective on the date when such Press Release is issued) and use its reasonable efforts to
post such information on its website or otherwise publicly disclose this information and (y) provide written notice to the Holders of Notes and the Trustee, in accordance with Section 16.5 of the Original Indenture, including through the
facilities of the Depositary. 
 (iii) Notwithstanding anything to the contrary in this First Supplemental Indenture, the Company may
irrevocably renounce its right to the Net Share Settlement Election in subsection (b)(i) above at any time prior to the 35th Scheduled Trading Day preceding the Maturity Date. Upon such renouncement, the Company will no longer have the right to make
the Net Share Settlement Election in respect of its Conversion Obligation and any such attempt shall have no effect. If the Company renounces its right to the Net Share Settlement Election, the Company will promptly (x) issue a Press Release
(and the renouncement will become effective on the date when such Press Release is issued) and use its reasonable efforts to post such information on its website or otherwise publicly disclose this information and (y) provide written notice to
the Holders of Notes and the Trustee, in accordance with Section 16.5 of the Original Indenture, including through the facilities of the Depositary . 
 (c) Notwithstanding the provisions described above in subsections (a) and (b), in satisfaction of the Conversion Obligation, the Company may direct the Conversion Agent to surrender, on or prior to the third VWAP
Trading Day after the relevant Conversion Date (or, if the Company has made the Net Share Settlement Election, on or prior to the commencement of the Observation Period), such Notes to a financial institution designated by the Company for exchange
in lieu of conversion. In order to accept any Notes surrendered for conversion, the designated institution must agree to deliver, in exchange for such Notes, the shares of Common Stock (or, if the Company has made the Net Share Settlement Election,
cash and shares, if any, of Common Stock) equal to the consideration due upon conversion pursuant to this Section 12.02, as is designated to the Conversion Agent by the Company. By the close of business on the second Scheduled Trading Day
following the relevant Conversion Date (or, if the Company has made the Net Share Settlement Election, the close of business on the Scheduled Trading Day immediately preceding the start of the relevant 

  

 46 

 
Observation Period), the Company shall notify, in the manner provided in Section 16.5 of the Original Indenture, the Holder surrendering Notes for
conversion that the Company has directed the designated financial institution to make an exchange in lieu of conversion and whether such financial institution shall deliver, upon exchange, shares of Common Stock or a combination of cash and shares,
if any, of Common Stock. If the designated institution accepts any such Notes, it shall deliver the appropriate number of shares of Common Stock (or, if the Company has made the Net Share Settlement Election, cash and the appropriate number of
shares, if any, of Common Stock) in accordance with Section 12.02(f). Any Notes exchanged by the designated institution shall remain outstanding. If the designated institution agrees to accept any Notes for exchange but does not timely deliver
the related consideration, or if such designated financial institution does not accept the Notes for exchange, the Company shall, no later than (i) the third VWAP Trading Day immediately following the relevant Conversion Date (or, with respect
to any Conversion Date occurring on or after the 30th Scheduled Trading Day prior to the Maturity Date, the third VWAP Trading Day following the last VWAP Trading Day of the Final Observation Period) or (ii) if the Company has made the Net
Share Settlement Election, the third VWAP Trading Day immediately following the last VWAP Trading Day of the related Observation Period, convert the Notes into the appropriate number of shares of Common Stock (or, if the Company has made the Net
Share Settlement Election, cash and the appropriate number of shares, if any, of Common Stock) due upon conversion pursuant to this Section 12.02. 
 (d) Notwithstanding subsections (a) and (b) of this Section 12.02, the Company shall satisfy the Conversion Obligation with respect to each $1,000 principal amount of Notes tendered for conversion to
which Additional Shares shall be added to the Conversion Rate as set forth in Section 12.01(f) pursuant to this subsection (d). 
 (i) If the Conversion Date (or, if the Company has made the Net Share Settlement Election, the last VWAP Trading Day of the applicable Observation Period) related to Notes surrendered for conversion is prior to the third Scheduled Trading
Day preceding the Effective Date of the Fundamental Change, the Company shall satisfy the related Conversion Obligation with respect to each $1,000 principal amount of Notes tendered for conversion as described in this subsection (d) by
delivering a number of shares of Common Stock equal to the Conversion Rate for each such $1,000 principal amount of Notes (or, if the Company has made the Net Share Settlement Election, the amount of cash and shares, if any, of Common Stock) based
on the Conversion Rate in effect, but without regard to the number of Additional Shares to be added to the Conversion Rate pursuant to Section 12.01(f), on the third VWAP Trading Day immediately following the related Conversion Date (or,
following the Company’s Net Share Settlement Election, the last VWAP 

  

 47 

 
Trading Day of the applicable Observation Period). As soon as practicable following the Effective Date of the Fundamental Change, the Company shall deliver
the increase in such amount of Reference Property in lieu of shares of Common Stock, if any, as if the Conversion Rate had been increased by such number of Additional Shares on the applicable Conversion Date (or, if the Company has made the Net
Share Settlement Election, during the related Observation Period and based upon the related Daily VWAP prices during such Observation Period). If such increased amount of cash and shares, if any, of Common Stock results in an increase to the amount
of cash to be paid to Holders, the Company shall pay such increase in cash, and if such increased amount results in an increase to the number of shares of Common Stock, the Company shall deliver such increase by delivering Reference Property based
on such increased number of shares. 
 (ii) If the Conversion Date (or, if the Company has made the Net Share Settlement
Election, the last VWAP Trading Day of the applicable Observation Period) related to Notes surrendered for conversion is on or following the third Scheduled Trading Day preceding the Effective Date of such Fundamental Change, the Company shall
satisfy the Conversion Obligation with respect to each $1,000 principal amount of Notes tendered for conversion as described in Section 12.01(b) (based on the Conversion Rate as increased by the Additional Shares pursuant to
Section 12.01(f)) on the later to occur of (1) the Effective Date of the Fundamental Change and (2) the third VWAP Trading Day immediately following the Conversion Date (or, if the Conversion Date occurs on or after the 30th Scheduled
Trading Day prior to the Maturity Date or if the Company has made the Net Share Settlement Election, the third VWAP Trading Day immediately following the last VWAP Trading Day of the Final Observation Period or of the applicable Observation Period,
as the case may be). 
 (e) Before any Holder of a Note shall be entitled to convert the same as set forth above, such Holder shall
(1) in the case of a Global Note, comply with the procedures of the Depositary in effect at that time and, if required, pay funds equal to interest payable on the next Interest Payment Date to which such Holder is not entitled as set forth in
subsection (i) of this Section 12.02 and, if required, pay all taxes or duties, if any, and (2) in the case of a Note issued in certificated form, (A) complete and manually sign and deliver an irrevocable written notice to the
Conversion Agent in the form set forth under Section 2.03 (or a facsimile thereof) (a “Notice of Conversion”) at the office of the Conversion Agent and shall state in writing therein the principal amount of Notes to be
converted and the name or names (with addresses) in which such Holder wishes the certificate or certificates for any shares of Common Stock, if any, to be delivered upon settlement of the Conversion Obligation to be registered, (B) surrender
such Notes, 

  

 48 

 
duly endorsed to the Company or in blank (and accompanied by appropriate endorsement and transfer documents), at the office of the Conversion Agent,
(C) if required, pay funds equal to interest payable on the next Interest Payment Date to which such Holder is not entitled as set forth in subsection (k) of this Section 12.02, and (D) if required, pay all taxes or duties, if
any. A Note shall be deemed to have been converted immediately prior to the close of business on the date (the “Conversion Date”) that the Holder has complied with the requirements set forth in this subsection (e). 
 No Notice of Conversion with respect to any Notes may be tendered by a Holder thereof if such Holder has also tendered a Fundamental Change Repurchase
Notice and not validly withdrawn such Fundamental Change Repurchase Notice in accordance with the applicable provisions of Section 14.01. 
 If more than one Note shall be surrendered for conversion at one time by the same Holder, the Conversion Obligation with respect to such Notes, if any, that shall be payable upon conversion shall be computed on the basis of the aggregate
principal amount of the Notes (or specified portions thereof to the extent permitted thereby) so surrendered. 
 (f) Delivery of the amounts
owing in satisfaction of the Conversion Obligation shall be made by the Company in no event later than the date specified in subsections (a) or (b), as applicable, of this Section 12.02, except to the extent specified in subsection
(d) of this Section 12.02. The Company shall make such delivery by paying the cash amount owed, if any, to the Holder of the Note surrendered for conversion, or such Holder’s nominee or nominees, and/or by issuing, or causing to be
issued, and delivering to such Holder, or such Holder’s nominee or nominees, certificates or a book-entry transfer through the Depositary for the number of full shares of Common Stock, if any, to which such Holder shall be entitled as part of
such Conversion Obligation (together with any cash in lieu of fractional shares). 
 (g) In case any Note shall be surrendered for partial
conversion, the Company shall execute and the Trustee shall, as provided in a Company Order, authenticate and deliver to or upon the written order of the Holder of the Note so surrendered, without charge to such Holder, a new Note or Notes in
authorized denominations in an aggregate principal amount equal to the unconverted portion of the surrendered Notes. 
 (h) If a Holder
submits a Note for conversion, the Company shall pay all stamp and other duties, if any, which may be imposed by the United States or any political subdivision thereof or taxing authority thereof or therein with respect to the issuance of shares of
Common Stock, if any, upon the conversion. However, the Holder shall pay any such tax which is due because the Holder requests any shares of Common Stock to be issued in a name other than the Holder’s name. 

  

 49 

 
The Company may refuse to deliver the certificates representing the shares of Common Stock being issued in a name other than the Holder’s name until the
Company receives a sum sufficient to pay any tax which will be due because the shares are to be issued in a name other than the Holder’s name. Nothing herein shall preclude any tax withholding required by law or regulations. 
 (i) Except as provided in Section 12.04, no adjustment shall be made for dividends on any shares issued upon the conversion of any Note as provided
in this Article 12. 
 (j) Upon the conversion of an interest in a Global Note, the Trustee, or the Custodian at the direction of the
Trustee, shall make a notation on such Global Note as to the reduction in the principal amount represented thereby. The Company shall notify the Trustee in writing of any conversion of Notes effected through any Conversion Agent other than the
Trustee. 
 (k) Upon conversion, a Holder shall not receive any separate cash payment for accrued and unpaid interest except as set forth
below. The Company’s settlement of the Conversion Obligation as described above shall be deemed to satisfy its obligation to pay the principal amount of the Note and accrued and unpaid interest to, but not including, the Conversion Date. As a
result, accrued and unpaid interest to, but not including, the Conversion Date shall be deemed to be paid in full rather than cancelled, extinguished or forfeited. Notwithstanding the preceding sentence, if Notes are converted after 5:00 p.m., New
York City time, on a Record Date, Holders of such Notes as of 5:00 p.m., New York City time, on the Record Date shall receive the interest payable on such Notes on the corresponding Interest Payment Date notwithstanding the conversion. Notes
surrendered for conversion during the period from 5:00 p.m., New York City time, on any Regular Record Date to 9:00 a.m., New York City time, on the corresponding Interest Payment Date must be accompanied by payment of an amount equal to the
interest payable on the Notes so converted; provided, however, that no such payment need be made (i) if the Company has specified a Fundamental Change Purchase Date that is after a Record Date and on or prior to the corresponding
Interest Payment Date; (ii) to the extent of any overdue interest existing at the time of conversion with respect to such Note; or (iii) with respect to any Conversion Date that occurs during the period from the close of business on the
Regular Record Date immediately preceding the Maturity Date to the Maturity Date. Except as described above, no payment or adjustment shall be made for accrued interest on converted Notes. 
 SECTION 12.03. Fractions Of Shares. 
 No fractional shares of Common Stock shall be issued upon conversion of any Note or Notes. If more than one Note shall be surrendered for conversion at one time by the same Holder, the number of full shares which shall be issuable 

  

 50 

 
upon conversion thereof shall be computed on the basis of the aggregate principal amount of the Notes (or specified portions thereof) so surrendered. Instead
of any fractional share of Common Stock that would otherwise be issuable upon conversion of any Note or Notes (or specified portions thereof), the Company shall calculate and pay a cash adjustment in respect of such fraction (calculated to the
nearest 1/100th of a share) based on the Last Reported Sale Price of the Common Stock on the Conversion Date (or, if the Company has made the Net Share Settlement Election, in an amount equal to the same fraction of the Daily VWAP of the Common
Stock on the last VWAP Trading Day of the relevant Observation Period). 
  

 51 

 SECTION 12.04. Adjustment Of Conversion Rate. 
 The Conversion Rate shall be adjusted from time to time by the Company as follows; provided that the Company shall not make any adjustments to the
Conversion Rate if Holders of the Notes participate (as a result of holding the Notes, and at the same time as holders of the Common Stock participate) in any the transactions described below as if such Holders held a number of shares of Common
Stock equal to the then-applicable Conversion Rate, multiplied by the principal amount (expressed in thousands) of Notes held by such Holders, without having to convert their Notes: 
 (a) In case the Company shall issue shares of Common Stock as a dividend or distribution to holders of all or substantially all of the outstanding Common
Stock, or shall effect a share split or share combination, the Conversion Rate shall be adjusted based on the following formula: 
  

											
	  	 	 	 	CR’ = CR0 ×	 	 OS’
	  	 	  	 
	 	 	 	OS0	  		  	

 where, 
 CR0 = the Conversion Rate in effect immediately prior to the Stock Record Date for such dividend or distribution or immediately prior to the effective date of such share split or combination, as the case
may be; 
 CR’ = the Conversion Rate in effect immediately after the Stock Record Date for such dividend or distribution or immediately
after the effective date of such share split or combination, as the case may be; 
 OS0 = the number of shares of Common Stock outstanding immediately prior to the Stock Record Date for such
dividend or distribution or immediately prior to the effective date of such share split or combination, as the case may be; and 
 OS’ =
the number of shares of Common Stock outstanding as of the Stock Record Date for such dividend or distribution and immediately after giving effect to such dividend or distribution or immediately after the effective date of such share split or
combination, as the case may be. 
 Such adjustment shall become effective immediately after 9:00 a.m., New York City time, on the Stock
Record Date fixed for such dividend or distribution, or the effective date for such share split or share combination. If any dividend or distribution of the type described in this Section 12.04(a) is declared but not so paid or made, or the
outstanding shares of Common Stock are not split or combined, as the case may be, the Conversion Rate shall be immediately 

  

 52 

 
readjusted, effective as of the date the Board of Directors determines not to pay such dividend or distribution, or split or combine the outstanding shares
of Common Stock, as the case may be, to the Conversion Rate that would then be in effect if such dividend, distribution, share split or share combination had not been declared. 
 (b) In case the Company shall distribute to all or substantially all holders of its outstanding shares of Common Stock any rights or warrants entitling
them (for a period expiring within 45 calendar days after the record date for such distribution) to subscribe for or purchase shares of Common Stock at a price per share less than the Last Reported Sale Price of the Common Stock on the Trading Day
immediately preceding the declaration date of such distribution, the Conversion Rate shall be adjusted based on the following formula: 
  

											
	 	 	 	 	CR’ = CR0 ×	 	OS0 + X	  	 	  	 
	 	 	 	OS0 + Y	  		  	

 where, 
 CR0 = the Conversion Rate in effect immediately prior to the Stock Record Date for such distribution; 
 CR’ = the Conversion Rate in effect immediately after the Stock Record Date for such distribution; 
 OS0 = the number of shares of Common Stock outstanding immediately prior to the
Stock Record Date for such distribution; 
 X = the total number of shares of Common Stock issuable pursuant to such rights or warrants; and

 Y = the number of shares of Common Stock equal to the aggregate price payable to exercise such rights or warrants divided by the average of
the Last Reported Sale Prices of Common Stock over the 10 consecutive Trading Day period ending on the Trading Day immediately preceding the Ex-Date for such distribution. 
 Such adjustment shall be successively made whenever any such rights or warrants are distributed and shall become effective immediately after the opening
of business on the Stock Record Date for such distribution. The Company shall not issue any such rights or warrants in respect of shares of the Common Stock held in treasury by the Company. To the extent that shares of the Common Stock are not
delivered after the expiration of such rights or warrants, the Conversion Rate shall be readjusted to the Conversion Rate that would then be in effect had the adjustments made upon the issuance of such rights or warrants been made on 

  

 53 

 
the basis of delivery of only the number of shares of Common Stock actually delivered. If such rights or warrants are not so issued, the Conversion Rate
shall again be adjusted to be the Conversion Rate that would then be in effect if such Stock Record Date for such distribution had not been fixed. 
 In determining whether any rights or warrants entitle the holders to subscribe for or purchase shares of Common Stock at less than such Last Reported Sale Price, and in determining the aggregate offering price of such shares of Common
Stock, there shall be taken into account any consideration received by the Company for such rights or warrants and any amount payable on exercise or conversion thereof, the value of such consideration, if other than cash, to be determined by the
Board of Directors. 
 (c) In case the Company shall, by dividend or otherwise, distribute to all or substantially all holders of its Common
Stock shares of any class of Capital Stock of the Company (other than Common Stock as covered by subsection (a) of this Section), evidences of its Indebtedness or other assets or property of the Company (including securities, but excluding
dividends or distributions covered by subsection (a) or (b) of this Section 12.04, dividends or distributions paid exclusively in cash and distributions described below in this subsection (c) with respect to Spin-Offs) (any of
such shares of Capital Stock, Indebtedness, or other asset or property hereinafter in this subsection (c) called the “Distributed Property”), then, in each such case the Conversion Rate shall be adjusted based on the following
formula: 
  

											
	 	 	 	 	CR’ = CR0 ×	 	SP0	  	 	  	 
	 	 	 	SP0 – FMV	  		  	

 where, 
 CR0 = the Conversion Rate in effect immediately prior to the Stock Record Date for such distribution; 
 CR’ = the Conversion Rate in effect immediately after the Stock Record Date for such distribution; 
 SP0 = the average of the Last Reported Sale Prices of Common Stock over the ten
(10) consecutive Trading Day period ending on the Trading Day immediately preceding the Ex-Date for such distribution; and 
 FMV = the
fair market value as determined by the Board of Directors or a committee thereof of the shares of Capital Stock, evidences of Indebtedness, assets or property distributed with respect to each outstanding share of Common Stock on the Ex-Date for such
distribution. 
  

 54 

 Such adjustment shall become effective immediately
prior to the opening of business on the Stock Record Date for such distribution; provided that if “FMV” as set forth above is equal to or greater than “SP0” as set forth above, in lieu of the foregoing adjustment, adequate provision shall be made so that each Holder of Notes has the right to receive, for each
$1,000 principal amount of Notes, the amount of Distributed Property such Holder would have received had such Holder owned a number of shares of Common Stock equal to the Conversion Rate on the Stock Record Date for such distribution, without being
required to convert the Notes. If such distribution is not so paid or made, the Conversion Rate shall again be adjusted to be the Conversion Rate that would then be in effect if such dividend or distribution had not been declared. If the Board of
Directors determines “FMV” for purposes of this Section 12.04(c) by reference to the actual or when issued trading market for any securities, it must in doing so consider the prices in such market over the same period used in
computing the Last Reported Sale Prices of the Common Stock over the ten consecutive Trading Day period ending on the Trading Day immediately preceding the Ex-Date for such distribution. 
 With respect to an adjustment pursuant to this subsection (c) where there has been a payment of a dividend or other distribution on the Common Stock
or shares of Capital Stock of any class or series, or similar equity interest, of or relating to a Subsidiary or other business unit (a “Spin-Off”), the Conversion Rate in effect immediately before 5:00 p.m., New York City time, on
the 10th Trading Day immediately following, and including, the effective date of the Spin-Off shall be increased based on the following formula: 
  

											
	 	 	 	 	CR’ = CR0 ×	 	FMV0 + MP0	  	 	  	 
	 	 	 	MP0	  		  	

 Where, 
 CR0 = the Conversion Rate in effect immediately prior to the 10th Trading Day immediately following the effective date of the Spin-Off; 
 CR’ = the Conversion Rate in effect immediately after the 10th Trading Day immediately following the effective date of the Spin-Off; 
 FMV0 = the average of the Last Reported Sale Prices of the Capital Stock or similar equity interest distributed to holders of Common Stock applicable to one share of Common Stock over the first 10
consecutive Trading Day period immediately following, and including, the effective date of the Spin-Off; and 

 55 

 MP0 = the average of the Last Reported Sale Prices of the Common Stock over the first 10 consecutive Trading Day period immediately following, and including, the
effective date of the Spin-Off. 
 Such adjustment shall occur on the 10th Trading Day from, and including, the effective date of the
Spin-Off; provided that in respect of any conversion within the 10 Trading Days immediately following, and including, the effective date of any Spin-Off, references with respect to the Spin-Off to 10 Trading Days shall be deemed replaced with
such lesser number of Trading Days as have elapsed between the effective date of such Spin-Off and the Conversion Date in determining the applicable Conversion Rate; provided further that in respect of any conversion within the first four
Trading Days following the effective date of such Spin-Off (if such Trading Days are also VWAP Trading Days), references to 10 Trading Days shall be deemed replaced with four (4) Trading Days. 
 Rights or warrants distributed by the Company to all holders of Common Stock, entitling the holders thereof to subscribe for or purchase shares of the
Company’s Capital Stock, including Common Stock (either initially or under certain circumstances), which rights or warrants, until the occurrence of a specified event or events (“Trigger Event”): (i) are deemed to be
transferred with such shares of Common Stock; (ii) are not exercisable; and (iii) are also issued in respect of future issuances of Common Stock, shall be deemed not to have been distributed for purposes of this Section 12.04 (and no
adjustment to the Conversion Rate under this Section 12.04 shall be required) until the occurrence of the earliest Trigger Event, whereupon such rights and warrants shall be deemed to have been distributed and an appropriate adjustment (if any
is required) to the Conversion Rate shall be made under this subsection (c). If any such rights or warrants are subject to events, upon the occurrence of which such rights or warrants become exercisable to purchase different securities, evidences of
Indebtedness or other assets, then the date of the occurrence of any and each such event shall be deemed to be the date of distribution and record date with respect to new rights or warrants with such rights (and a termination or expiration of the
existing rights or warrants without exercise by any of the holders thereof). In addition, in the event of any distribution (or deemed distribution) of rights or warrants, or any Trigger Event or other event (of the type described in the preceding
sentence) with respect thereto that was counted for purposes of calculating a distribution amount for which an adjustment to the Conversion Rate under this Section 12.04 was made, (1) in the case of any such rights or warrants that shall
all have been redeemed or repurchased without exercise by any holders thereof, the Conversion Rate shall be readjusted upon such final redemption or repurchase to give effect to such distribution or Trigger Event, as the case may be, as though it
were a cash distribution, equal to the per share redemption or repurchase price received by a holder or holders of Common Stock with respect to such rights or warrants (assuming such holder had retained such rights or warrants), made to all holders
of Common Stock as of the date of such 

  

 56 

 
redemption or repurchase, and (2) in the case of such rights or warrants that shall have expired or been terminated without exercise by any holders
thereof, the Conversion Rate shall be readjusted as if such rights and warrants had not been issued. 
 For purposes of this subsection
(c) and subsections (a) and (b) of this Section 12.04, any dividend or distribution to which this subsection (c) is applicable that also includes shares of Common Stock to which subsection (a) of this Section 12.04
applies or rights or warrants to subscribe for or purchase shares of Common Stock to which subsection (a) or (b) of this Section 12.04 applies (or both), shall be deemed instead to be (1) a dividend or distribution of the
evidences of Indebtedness, assets or shares of Capital Stock other than such shares of Common Stock or rights or warrants, to which this subsection (c) applies (and any Conversion Rate adjustment required by this subsection (c) with
respect to such dividend or distribution shall then be made) immediately followed by (2) a dividend or distribution of such shares of Common Stock or such rights or warrants (and any further Conversion Rate adjustment required by subsections
(a) and (b) of this Section 12.04 with respect to such dividend or distribution shall then be made), except (A) the Ex-Date of such dividend or distribution shall under this subsection (c) be substituted as “the
Ex-Date” within the meaning of subsection (a) and subsection (b) and (B) any shares of Common Stock included in such dividend or distribution shall not be deemed “outstanding immediately prior to the Ex-Date for such
dividend or distribution or immediately prior to the effective date of such share split or combination, as the case may be” within the meaning of subsection (a) or “outstanding immediately prior to the Ex-Date for such
distribution” within the meaning of subsection (b). 
 (d) In case the Company shall pay dividends or make distributions consisting
exclusively of cash to all or substantially all holders of its Common Stock, the Conversion Rate shall be adjusted based on the following formula: 
  

											
	 	 	 	 	CR’ = CR0 ×	 	SP0	  	 	  	 
	 	 	 	SP0 –C	  		  	

 where, 
 CR0 = the Conversion Rate in effect immediately prior to the Stock Record Date for such distribution; 
 CR’ = the Conversion Rate in effect immediately after the Stock Record Date for such distribution; 
 SP0 = the Last Reported Sale Price of Common Stock on the Trading Day immediately
preceding the Ex-Date for such distribution; 
  

 57 

 C = the amount in cash per share the Company distributes to holders of Common Stock in such distribution.

 Such adjustment shall become effective immediately after the opening of business on
the Stock Record Date for such dividend or distribution; provided that if the portion of the cash so distributed applicable to one share of the Common Stock is equal to or greater than SP0 as set forth above, in lieu of the foregoing adjustment, adequate provision shall be made so that each Holder of Notes shall receive on the date on which such
cash dividend is distributed to holders of Common Stock, for each $1,000 principal amount of Notes, the amount of cash such Holder would have received had such Holder owned a number of shares equal to the Conversion Rate on the Ex-Date for such
distribution, without being required to convert the Notes. If such dividend or distribution is not so paid or made, the Conversion Rate shall again be adjusted to be the Conversion Rate that would then be in effect if such dividend or distribution
had not been declared. 
 For the avoidance of doubt, for purposes of this subsection (d), in the event of any reclassification of the Common
Stock, as a result of which the Notes become convertible into more than one class of Common Stock, if an adjustment to the Conversion Rate is required pursuant to this subsection (d), references in this Section 12.04 to one share of Common
Stock or Last Reported Sale Price of one share of Common Stock shall be deemed to refer to a unit or to the price of a unit consisting of the number of shares of each class of Common Stock into which the Notes are then convertible equal to the
numbers of shares of such class issued in respect of one share of Common Stock in such reclassification. The above provisions of this paragraph shall similarly apply to successive reclassifications. 
 (e) In case the Company or any of its Subsidiaries make a payment in respect of a tender offer or exchange offer for all or any portion of the Common
Stock, to the extent that the cash and value of any other consideration included in the payment per share of Common Stock exceeds the Last Reported Sale Price of the Common Stock on the Trading Day next succeeding the last date on which tenders or
exchanges may be made pursuant to such tender or exchange offer (as it may be amended), the Conversion Rate shall be increased based on the following formula: 
  

											
	 	 	 	 	CR’ = CR0 ×	 	 AC + (SP’ × OS’)
	  	 	  	 
	 	 	 	OS0 × SP’	  		  	

 where, 
 CR0 = the Conversion Rate in effect on the date such tender or exchange offer expires; 
  

 58 

 CR’ = the Conversion Rate in effect on the day next succeeding the date such tender or exchange
offer expires; 
 AC = the aggregate value of all cash and any other consideration as determined by the Board of Directors or a committee
thereof paid or payable for shares purchased in such tender or exchange offer; 
 OS0 = the number of shares of Common Stock outstanding immediately prior to the date such tender or
exchange offer expires; 
 OS’ = the number of shares of Common Stock outstanding immediately after the date such tender or exchange
offer expires (after giving effect to such tender offer or exchange offer); and 
 SP’ = the Last Reported Sale Price of Common Stock on
the Trading Day next succeeding the date such tender or exchange offer expires. 
 Such adjustment shall become effective immediately after
close of business on the Trading Day next succeeding the date such tender or exchange offer expires. If the Company or its Subsidiary is obligated to purchase shares of Common Stock pursuant to any such tender or exchange offer, but the Company or
its Subsidiary is permanently prevented by applicable law from effecting all or any such purchases or all or any portion of such purchases are rescinded, the Conversion Rate shall again be adjusted to be the Conversion Rate that would then be in
effect if such tender or exchange offer had not been made or had only been made in respect of the purchases that had been effected. 
 No
adjustment to the Conversion Rate shall be made if the application of any of the foregoing formulas (other than in connection with a share combination) would result in a decrease in the Conversion Rate. 
 For purposes of this Section 12.04 the term “Stock Record Date” shall mean, with respect to any dividend, distribution or other
transaction or event in which the holders of Common Stock have the right to receive any cash, securities or other property or in which the Common Stock (or other applicable security) is exchanged for or converted into any combination of cash,
securities or other property, the date fixed for determination of shareholders entitled to receive such cash, securities or other property (whether such date is fixed by the Board of Directors or by statute, contract or otherwise). 
 Notwithstanding anything to the contrary, if the Company has made the Net Share Settlement Election, then each reference to “Stock Record
Date” in this Section 12.04 shall be deemed as a reference to “Ex-Date” on the date on which the Net Share Settlement Election becomes effective pursuant to Section 12.02(b)(i) and Section 12.02(b)(ii).

  

 59 

 (f) In addition to those required by subsections (a), (b), (c), (d) and (e) of this
Section 12.04, and to the extent permitted by applicable law and the rules of the NASDAQ Global Select Market or any other securities exchange on which the Common Stock is then listed, the Company from time to time may increase the Conversion
Rate by any amount for a period of at least 20 calendar days if the Board of Directors determines that such increase would be in the Company’s best interest. Whenever the Conversion Rate is increased pursuant to the preceding sentence, the
Company shall mail to the Holder of each Note at his last address appearing on the Register provided for in Section 16.5 of the Original Indenture and the Trustee a notice of the increase at least 15 calendar days prior to the date the
increased Conversion Rate takes effect, and such notice shall state the increased Conversion Rate and the period during which it will be in effect. In addition, the Company may also (but is not required to) increase the Conversion Rate to avoid or
diminish any income tax to holders of Common Stock or rights to purchase Common Stock in connection with any dividend or distribution of shares (or rights to acquire shares) or similar event. 
 (g) Without limiting the foregoing, no adjustment to the Conversion Rate need be made: 
 (i) upon the issuance of any shares of Common Stock pursuant to any present or future plan providing for the reinvestment of dividends or
interest payable on securities of the Company and the investment of additional optional amounts in shares of Common Stock under any plan; 
 (ii) upon the issuance of any shares of Common Stock or options or rights to purchase shares of Common Stock pursuant to any present or future employee, director or consultant benefit plan or program of or assumed by
the Company or any of its Subsidiaries; 
 (iii) upon the issuance of any shares of Common Stock pursuant to any option,
warrant, right, or exercisable, exchangeable or convertible security not described in clause (ii) above and outstanding as of the date of this First Supplemental Indenture; 
 (iv) for a change in the par value of the Common Stock; or 
 (v) for accrued and unpaid Interest. 
 (h) All calculations and other determinations under this Article 12 shall be made by the Company and shall be made to the nearest cent or to the nearest one-ten thousandth (1/10,000) of a share, as the case may be. No adjustment shall
be made to the Conversion Rate unless such adjustment would require a change of at least 1% in the Conversion Rate then in effect at such time. The Company shall carry forward any adjustments that are less than 1% of the Conversion Rate and 

  

 60 

 
make such carried forward adjustments, regardless of whether the aggregate adjustment is less than 1% (1) annually, on the anniversary of the date of
this First Supplemental Indenture, (2) upon a Fundamental Change or (3) on each day on and after the 27th Scheduled Trading Day prior to the Maturity Date. 
 (i) In any case in which this Section 12.04 provides that an adjustment shall become effective immediately after (1) the Stock Record Date for an event or (2) the last date on which tenders or exchanges
may be made pursuant to any tender or exchange offer pursuant to subsection (e) of this Section (each an “Adjustment Determination Date”), the Company may elect to defer until the occurrence of the applicable Adjustment Event
(as hereinafter defined) (x) issuing to the Holder of any Note converted after such Adjustment Determination Date and before the occurrence of such Adjustment Event, the additional shares of Common Stock or other securities (or, if the Company
has made the Net Share Settlement Election, cash and, if applicable, shares of Common Stock or other securities) issuable upon such conversion by reason of the adjustment required by such Adjustment Event over and above the amounts deliverable upon
such conversion before giving effect to such adjustment and (y) paying to such Holder any amount in cash in lieu of any fraction pursuant to Section 12.03. For purposes of this subsection (i), the term “Adjustment Event”
shall mean: 
 (i) in any case referred to in clause (1) hereof, the date any dividend or distribution of Common Stock,
shares of Capital Stock, evidences of Indebtedness, other assets or property or cash is paid or made, the effective date of any share split or combination or the date of expiration of any rights or warrants, and 
 (ii) in any case referred to in clause (2) hereof, the date a sale or exchange of Common Stock pursuant to such tender or exchange
offer is consummated and becomes irrevocable. 
 (j) For purposes of this Section 12.04, the number of shares of Common Stock at any
time outstanding shall not include shares held in the treasury of the Company but shall include shares issuable in respect of scrip certificates issued in lieu of fractions of shares of Common Stock. 
 (k) For the avoidance of doubt, if a Holder converts Notes prior to the Effective Date of a Fundamental Change, and the Fundamental Change does not
occur, the Holder shall not be entitled to Additional Shares in connection with such conversion. 
 (l) With respect to a conversion of Notes
pursuant to this Article 12, at and after the close of business on the Conversion Date (or, if the Company has made the Net Share Settlement Election, the last VWAP Trading Day of the related Observation Period) (each such day the “Relevant
Date”), the Person in 

  

 61 

 
whose name any certificate representing any shares of Common Stock issuable upon such conversion is registered shall be treated as a stockholder of record of
the Company on such Relevant Date; provided, however, that if any such shares of Common Stock constitute Additional Shares, then the Relevant Date with respect to such shares that constitute Additional Shares shall instead be deemed to be the
later of (i) the Conversion Date (or, if the Company has made the Net Share Settlement Election, last VWAP Trading Day of the related Observation Period) and (ii) the Effective Date of the Fundamental Change resulting in the Additional
Shares. On and after the Conversion Date with respect to a conversion of Notes pursuant hereto, all rights of the Holders of such Notes shall terminate, other than the right to receive the consideration deliverable upon conversion of such Notes as
provided herein. A Holder of a Note is not entitled, as such, to any rights of a holder of Common Stock until, if such Holder converts such Note and is entitled pursuant hereto to receive shares of Common Stock in respect of such conversion, the
close of business on the Relevant Date or respective Relevant Dates, as the case may be, with respect to such conversion. 
 (m) Whenever the
Company has made the Net Share Settlement Election and any provision of this Article 12 requires a calculation of Last Reported Sale Prices or Daily VWAP over a span of multiple days, the Company shall make appropriate adjustments to the Daily
Settlement Amount (determined in good faith by the Board of Directors) to account for any adjustment to the Conversion Rate that becomes effective, or any event requiring an adjustment to the Conversion Rate where the Ex-Date of the event occurs, at
any time during the period from which such calculation is to be calculated; provided that such adjustments shall only be made to the Daily Settlement Amounts relating to days prior to the date that the adjustment to the Conversion Rate
becomes effective. 
 SECTION 12.05. Notice Of Adjustments Of Conversion Rate. 
 Whenever the Conversion Rate is adjusted as herein provided: 
 (a) the Company shall compute the adjusted Conversion Rate in accordance with Section 12.04 and shall prepare a certificate signed by the Chief Financial Officer of the Company setting forth the adjusted
Conversion Rate and showing in reasonable detail the facts upon which such adjustment is based, and such certificate shall promptly be filed with the Trustee and with each Conversion Agent (if other than the Trustee); and 
 (b) upon each such adjustment, a notice stating that the Conversion Rate has been adjusted and setting forth the adjusted Conversion Rate shall be
required, such notice shall be provided by the Company to all Holders in accordance with Section 16.5 of the Original Indenture. 
  

 62 

 Neither the Trustee nor any Conversion Agent shall be under any duty or responsibility with respect to
any such certificate or the information and calculations contained therein, except to exhibit the same to any Holder of Notes desiring inspection thereof at its office during normal business hours.  
 SECTION 12.06. Company To Reserve Common Stock. 
 The Company shall at all times reserve and keep available, free from preemptive rights, out of its authorized but unissued Common Stock, for the purpose of effecting the conversion of Notes, the full number of shares
of Common Stock then issuable upon the conversion of all Outstanding Notes. 
 SECTION 12.07. Taxes On Conversions. 

Except as provided in the next sentence, the Company shall pay all documentary, stamp or similar issue or transfer tax due that may be payable in
respect of the issue or delivery of shares of Common Stock on conversion of Notes pursuant hereto. The Company shall not, however, be required to pay any tax or duty that may be payable in respect of (i) income of the Holder, or (ii) any
transfer involved in the issue and delivery of shares of Common Stock in a name other than that of the Holder of the Note or Notes to be converted, and no such issue or delivery shall be made unless and until the Person requesting such issue has
paid to the Company the amount of any such tax or duty, or has established to the satisfaction of the Company that such tax or duty has been paid. 
 SECTION 12.08 . Certain Covenants. 
 Before taking any action which would cause an adjustment reducing the Conversion
Rate below the then par value, if any, of the shares of Common Stock issuable upon conversion of the Notes, the Company shall take all corporate action which it reasonably determines may be necessary in order that the Company may validly and legally
issue shares of such Common Stock at such adjusted Conversion Rate. 
 The Company covenants that all shares of Common Stock issued upon
conversion of Notes shall be fully paid and non-assessable by the Company and free from all taxes, liens and charges with respect to the issue thereof. 
 The Company further covenants that if at any time the Common Stock shall be listed for trading on any other national securities exchange the Company shall, if permitted and required by the rules of such exchange, list
and keep listed, so long as the Common Stock shall be so listed on such exchange, all Common Stock issuable upon conversion of the Notes. 
 SECTION 12.09. Cancellation Of Converted Notes. 
  

 63 

 All Notes delivered for conversion shall be delivered to the Trustee or its agent and canceled by the
Trustee as provided in Section 3.9 of the Original Indenture. 
 SECTION 12.10. Provision In Case Of Effect Of
Reclassification, Consolidation, Merger Or Sale. 
 If any of the following events occur, namely (i) any Fundamental Change described
in clause (2) of the definition of Fundamental Change, (ii) any reclassification or change of the outstanding shares of Common Stock (other than a change in par value, or from par value to no par value, or from no par value to par value,
or as a result of a split, subdivision or combination), (iii) any consolidation, binding share exchange, recapitalization, reclassification, merger, combination or other similar event of the Company with another Person, or (iv) any sale,
transfer or conveyance of all or substantially all of the property and assets of the Company to any other Person, in any case as a result of which holders of Common Stock shall be entitled to receive cash, securities or other property or assets with
respect to or in exchange for such Common Stock (any such event described in clauses (i) through (iv) a “Merger Event”), then: 
 (a) the Company or the successor or purchasing Person, as the case may be, shall execute with the Trustee a supplemental indenture (which shall comply with the Trust Indenture Act as in force at the date of execution
of such supplemental indenture if such supplemental indenture is then required to so comply) permitted under Section 8.01(f) providing for the conversion and settlement of the Notes as set forth in this First Supplemental Indenture. Such
supplemental indenture shall provide for adjustments which shall be as nearly equivalent as may be practicable to the adjustments provided for in this Article 12 and the Trustee may conclusively rely on the determination by the Company of the
equivalency of such adjustments. If, in the case of any Merger Event, the Reference Property includes shares of stock or other securities and assets of a company other than the successor or purchasing company, as the case may be, in such change of
control, consolidation, binding share exchange, recapitalization, reclassification, merger, combination, sale, transfer or conveyance or Fundamental Change described in clause (2) of the definition of Fundamental Change, then such supplemental
indenture shall also be executed by such other company and shall contain such additional provisions to protect the interests of the Holders of the Notes as the Board of Directors shall reasonably consider necessary by reason of the foregoing,
including to the extent required by the Board of Directors and practicable the provisions providing for the repurchase rights set forth in Article 14. 
 In the event a supplemental indenture is executed pursuant to this Section 12.10, the Company shall promptly file with the Trustee an Officers’ Certificate briefly stating the reasons therefore, the kind or
amount of cash, securities or 

  

 64 

 
property or assets that will constitute the Reference Property after any such Merger Event, any adjustment to be made with respect thereto and that all
conditions precedent have been complied with, and shall promptly mail notice thereof to all Holders. 
 If any securities to be provided for
the purpose of conversion of Notes hereunder require registration with or approval of any governmental authority under any federal or state law before such securities may be validly issued upon conversion, each supplemental indenture executed
pursuant to this Section shall provide that the Company or the successor or the purchasing Person, as the case may be, or if the Reference Property includes shares of stock or other securities and assets of a company other than the successor or
purchasing company, as the case may be, then such company, shall use all commercially reasonable efforts, to the extent then permitted by the rules and interpretations of the SEC (or any successor thereto), to secure such registration or approval in
connection with the conversion of Notes. 
 (b) Notwithstanding the provisions of Section 12.02(a) to (d), and subject to the provisions
of Section 12.01, at the effective time of such Merger Event, the right to convert each $1,000 principal amount of Notes shall be changed to a right to convert such Notes by reference to the kind and amount of cash, securities or other property
or assets that a holder of a number of shares of Common Stock equal to the Conversion Rate immediately prior to such transaction would have owned or been entitled to receive (the “Reference Property”); provided that if the
Company has made the Net Share Settlement Election, such a Holder shall be entitled from and after the effective time of such transaction to convert its Notes into cash and, in lieu of Common Stock, if any, the same type (and in the same proportion)
of Reference Property, based on the Daily Settlement Amounts of Reference Property in an amount equal to the applicable Conversion Rate, as described under Section 12.02(b). For purposes of determining the constitution of Reference Property,
the type and amount of consideration that a holder of Common Stock would have been entitled to in the case of change of controls, consolidations, binding share exchanges, recapitalizations, reclassifications, mergers, combinations, sales or
transfers of assets or Fundamental Changes described in clause (2) of the definition of Fundamental Change or other transactions that cause the Common Stock to be converted into the right to receive more than a single type of consideration
(determined, based in part upon any form of stockholder election) shall be deemed to be the (i) weighted average of the types and amounts of consideration received by the holders of Common Stock that affirmatively make such an election or
(ii) if no holders of Common Stock affirmatively make such election, the types and amounts of consideration actually received by such holders. The Company shall not become a party to any such transaction unless its terms are consistent with the
preceding. None of the foregoing provisions shall affect the 

  

 65 

 
right of a Holder of Notes to convert its Notes in accordance with the provisions of this Article 12 prior to the effective date. 
 (c) The Company shall cause notice of the execution of such supplemental indenture to be mailed to each Holder, at his address appearing on the Register
provided for in this First Supplemental Indenture, within 20 calendar days after execution thereof. Failure to deliver such notice shall not affect the legality or validity of such supplemental indenture. 
 (d) The above provisions of this Section shall similarly apply to successive Merger Events. 
 SECTION 12.11. Responsibility Of Trustee For Conversion Provisions. 
 The Trustee, subject to the provisions of Section 11.2 of the Original Indenture, and any Conversion Agent shall not at any time be under any duty or
responsibility to any Holder of Notes to determine whether any facts exist which may require any adjustment of the Conversion Rate, or with respect to the nature or extent of any such adjustment when made, or with respect to the method employed,
herein or in any supplemental indenture provided to be employed, in making the same, or whether a supplemental indenture need be entered into. Neither the Trustee, subject to the provisions of Section 11.2 of the Original Indenture, nor any
Conversion Agent shall be accountable with respect to the validity or value (or the kind or amount) of any Common Stock, or of any other securities or property or cash, which may at any time be issued or delivered upon the conversion of any Notes;
and it or they do not make any representation with respect thereto. Neither the Trustee, subject to the provisions of Section 11.2 of the Original Indenture, nor any Conversion Agent shall be responsible for any failure of the Company to make
or calculate any cash payment or to issue, transfer or deliver any shares of Common Stock or share certificates or other securities or property or cash upon the surrender of any Note for the purpose of conversion; and the Trustee, subject to the
provisions of Section 11.2 of the Original Indenture, and any Conversion Agent shall not be responsible for any failure of the Company to comply with any of the covenants of the Company contained in this Article 12. 
 ARTICLE 13 
 DISCHARGE

 SECTION 13.01. Discharge of Liability on Notes. 
 When (1) the Company shall deliver to the Registrar for cancellation all Notes theretofore authenticated (other than any Notes which have been
mutilated, destroyed, lost or wrongfully taken and in lieu of or in substitution for which 

  

 66 

 
other Notes shall have been authenticated and delivered) and not theretofore canceled or (2) all the Notes not theretofore canceled or delivered to the
Registrar for cancellation shall have (a) been deposited for conversion (or, if the Company has made the Net Share Settlement Election, after all related Observation Periods have elapsed) and the Company shall deliver to the Holders shares of
Common Stock (or, if the Company has made the Net Share Settlement Election, a combination of cash and shares, if any, of Common Stock), sufficient to pay all amounts owing in respect of all Notes (other than any Notes which shall have been
mutilated, destroyed, lost or wrongfully taken and in lieu of or in substitution for which other Notes shall have been authenticated and delivered) not theretofore canceled or delivered to the Registrar for cancellation or (b) become due and
payable on the Maturity Date, Fundamental Change Repurchase Date or otherwise, and the Company shall deposit with the Trustee cash sufficient to pay all amounts owing in respect of all Notes (other than any Notes which shall have been mutilated,
destroyed, lost or wrongfully taken and in lieu of or in substitution for which other Notes shall have been authenticated and delivered) not theretofore canceled or delivered to the Registrar for cancellation, including the principal amount and
interest accrued and unpaid to the Maturity Date, Fundamental Change Repurchase Date or other such date, and if in either case (1) or (2) the Company shall also pay or cause to be paid all other sums payable hereunder by the Company, then
this First Supplemental Indenture with respect to the Notes shall cease to be of further effect (except as to (i) remaining rights of registration of transfer, substitution and exchange and conversion of Notes, (ii) rights hereunder of
Holders to receive from the Trustee payments of the amounts then due, including interest with respect to the Notes and the other rights, duties and obligations of Holders, as beneficiaries hereof solely with respect to the amounts, if any, so
deposited with the Trustee and (iii) the rights, obligations and immunities of the Trustee, Authenticating Agent, Paying Agent, Conversion Agent and Registrar under this First Supplemental Indenture with respect to the Notes), and the Trustee,
on demand of the Company accompanied by an Officers’ Certificate and an Opinion of Counsel as required by Section 13.03 and at the cost and expense of the Company, shall execute proper instruments acknowledging satisfaction of and
discharging this First Supplemental Indenture with respect to the Notes; provided however, the Company hereby agrees to reimburse the Trustee, Authenticating Agent, Paying Agent, Conversion Agent and Registrar for any costs or expenses
thereafter reasonably and properly incurred by the Trustee, Authenticating Agent, Paying Agent, Conversion Agent and Registrar and to compensate the Trustee, Authenticating Agent, Paying Agent, Conversion Agent and Registrar for any services
thereafter reasonably and properly rendered by the Trustee, Authenticating Agent, Paying Agent, Conversion Agent and Registrar in connection with this First Supplemental Indenture with respect to the Notes. 
 SECTION 13.02. Reinstatement. 
  

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 If the Trustee or the Paying Agent is unable to apply any money to the Holders entitled thereto by reason
of any order or judgment of any court of governmental authority enjoining, restraining or otherwise prohibiting such application, the Company’s obligations under this First Supplemental Indenture with respect to the Notes shall be revived and
reinstated as though no deposit had occurred pursuant to Section 13.01 until such time as the Trustee or the Paying Agent is permitted to apply all such money in accordance with this First Supplemental Indenture and the Notes to the Holders
entitled thereto; provided, however, that if the Company makes any payment of principal amount of or interest on any Note following the reinstatement of its obligations, the Company shall be subrogated to the rights of the Holders of such Notes to
receive such payment from the money held by the Trustee or Paying Agent. 
 SECTION 13.03. Officers’ Certificate; Opinion of
Counsel. 
 Upon any application or demand by the Company to the Trustee to take any action under Section 13.01, the Company shall
furnish to the Trustee an Officers’ Certificate or Opinion of Counsel stating that all conditions precedent, if any, provided for in this First Supplemental Indenture relating to the proposed action have been complied with. 
 ARTICLE 14 
 REPURCHASE
OF NOTES 
 SECTION 14.01. Right To Require Repurchase Upon A Fundamental Change. 
 (a) If a Fundamental Change occurs at any time, then each Holder shall have the right, at such Holder’s option, to require the Company to repurchase
all of such Holder’s Notes or any portion thereof that is a multiple of $1,000 principal amount, for cash on the date (the “Fundamental Change Repurchase Date”) specified by the Company that is not less than 20 calendar days
and not more than 35 calendar days after the date of the Fundamental Change Repurchase Right Notice at a repurchase price equal to 100% of the principal amount thereof, together with accrued and unpaid interest thereon to, but excluding, the
Fundamental Change Repurchase Date, unless such Fundamental Change Repurchase Date falls after a Regular Record Date and on or prior to the corresponding Interest Payment Date, in which case the Company shall pay the full amount of accrued and
unpaid interest payable on such Interest Payment Date to the Holder of record at the close of business on the corresponding Regular Record Date (the “Fundamental Change Repurchase Price”). 
 However, notwithstanding the foregoing, Holders shall not have the right to require the Company to repurchase any Notes (and the Company shall not be

  

 68 

 
required to deliver the Fundamental Change Repurchase Right Notice incidental thereto) if (x) a Fundamental Change under clauses (1) or (2) of
the definition of Fundamental Change occurs if at least 90% of the consideration paid for the Company’s Common Stock (excluding cash payments for fractional shares and, cash payments made pursuant to dissenters’ appraisal rights and cash
dividends) in the case of a Fundamental Change under clauses (1) or (2) of the definition of Fundamental Change consists of shares of Capital Stock or American Depositary Receipts in respect of shares of Capital Stock traded on any of the
New York Stock Exchange, the American Stock Exchange, the NASDAQ Global Select Market or the NASDAQ Global Market (or any of their respective successors) (or will be so traded immediately following the completion of the merger or consolidation or
such other transaction) and, as a result of such transaction or transactions, the Notes become convertible into such shares of Capital Stock or such American Depositary Receipts (or, if the Company has made the Net Share Settlement Election, into
cash (in respect of the principal portion) and, if applicable, such shares of such Capital Stock or such American Depositary Receipts) or (y) a Fundamental Change under clause (3) of the definition of Fundamental Change occurs and such
Fundamental Change is also a Fundamental Change under clauses (1) or (2) of the definition of Fundamental Change that meets the requirements of clause (x) above. 
 Repurchases of Notes under this Section 14.01 shall be made, at the option of the Holder thereof, upon: 
 (i) if the Notes are held in certificated form, delivery to the Trustee (or other Paying Agent appointed by the Company) by a Holder of a
duly completed notice (the “Fundamental Change Repurchase Notice”) in the form set forth on the reverse of the Note or, if the Notes are held in global form, a notice that complies with the Applicable Procedures, prior to the close
of business on the Business Day immediately preceding the Fundamental Change Repurchase Date; and 
 (ii) delivery or
book-entry transfer of the Notes to the Trustee (or other Paying Agent appointed by the Company) at any time after delivery of the Fundamental Change Repurchase Notice (together with all necessary endorsements) at the Corporate Trust Office of the
Trustee (or other Paying Agent appointed by the Company), such delivery being a condition to receipt by the Holder of the Fundamental Change Repurchase Price therefor; provided that such Fundamental Change Repurchase Price shall be so paid
pursuant to this Section 14.01 only if the Note so delivered to the Trustee (or other Paying Agent appointed by the Company) shall conform in all respects to the description thereof in the related Fundamental Change Repurchase Notice.

 The Fundamental Change Repurchase Notice shall state: 
  

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 (A) if certificated, the certificate numbers of Notes to be delivered for repurchase;

 (B) the portion of the principal amount of Notes to be repurchased, which must be $1,000 or an integral multiple thereof;
and 
 (C) that the Notes are to be repurchased by the Company pursuant to the applicable provisions of the Notes and this
First Supplemental Indenture. 
 Any purchase by the Company contemplated pursuant to the provisions of this Section 14.01 shall be
consummated by the delivery of the consideration to be received by the Holder promptly following the later of the Fundamental Change Repurchase Date and the time of the book-entry transfer or delivery of the Note. 
 The Trustee (or other Paying Agent appointed by the Company) shall promptly notify the Company of the receipt by it of any Fundamental Change Repurchase
Notice or written notice of withdrawal thereof in accordance with the provisions of subsection (c) of this Section 14.01. 
 Any
Note that is to be repurchased only in part shall be surrendered to the Trustee (with, if the Company or the Trustee so requires, due endorsement by, or a written instrument of transfer in form satisfactory to the Company and the Trustee duly
executed by the Holder thereof or his attorney duly authorized in writing), and the Company shall execute, and the Trustee shall authenticate and make available for delivery to the Holder of such Note without service charge, a new Note or Notes,
containing identical terms and conditions, each in an authorized denomination in aggregate principal amount equal to and in exchange for the unrepurchased portion of the principal of the Note so surrendered. 
 (b) After the occurrence of a Fundamental Change, but on or before the 10th calendar day after the Effective Date of such Fundamental Change, the Company
shall provide to all Holders of record of the Notes and the Trustee and Paying Agent a notice (the “Fundamental Change Repurchase Right Notice”) of the occurrence of such Fundamental Change and of the repurchase right, if any, at
the option of the Holders arising as a result thereof. Such mailing shall be by first class mail. Simultaneously with providing such Fundamental Change Repurchase Right Notice, the Company shall publish a notice containing the information included
therein in a newspaper of general circulation in the City of New York or on the Company’s website or through such other public medium as the Company may use at such time. 
 Each Fundamental Change Repurchase Right Notice shall specify (if applicable): 
  

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 (i) the events causing the Fundamental Change; 
 (ii) the date of the Fundamental Change; 
 (iii) the Fundamental Change Repurchase Date and the last date on which a Holder may exercise the repurchase right; 
 (iv) the Fundamental Change Repurchase Price; 
 (v) the name and address of the Paying Agent
and the Conversion Agent; 
 (vi) the applicable Conversion Rate and any adjustments to the applicable Conversion Rate;

 (vii) that the Notes with respect to which a Fundamental Change Repurchase Notice has been delivered by a Holder may be
converted only if the Holder withdraws the Fundamental Change Repurchase Notice in accordance with the terms of this First Supplemental Indenture; 
 (viii) that the Holder must exercise the repurchase right on or prior to the close of business on the third Business Day immediately preceding the Fundamental Change Repurchase Date (the “Fundamental Change
Expiration Time”); 
 (ix) that the Holder shall have the right to withdraw any Notes surrendered for repurchase
prior to the Fundamental Change Expiration Time; and 
 (x) the procedures that Holders must follow to require the Company to
repurchase their Notes. 
 No failure of the Company to give the foregoing notices and no defect therein shall limit the Holders’
repurchase rights or affect the validity of the proceedings for the repurchase of the Notes pursuant to this Section 14.01. 
 (c) A
Fundamental Change Repurchase Notice may be withdrawn by means of a written notice of withdrawal delivered to the Paying Agent in accordance with the Fundamental Change Repurchase Right Notice at any time prior to the close of business on the
Business Day prior to the Fundamental Change Repurchase Date, specifying: 
 (i) if certificated Notes have been issued, the
certificate numbers of the withdrawn Notes, 
  

 71 

 (ii) the principal amount of the Note with respect to which such notice of withdrawal is being submitted,
and 
 (iii) the principal amount, if any, of such Note that remains subject to the original Fundamental Change Repurchase Notice, which
portion must be in principal amounts of $1,000 or an integral multiple of $1,000; 
 provided, however, that if the Notes are not in
certificated form, the notice must comply with the Applicable Procedures. 
 (d) On or prior to 11:00 a.m., New York City time, on the
Business Day on the Fundamental Change Repurchase Date, the Company shall deposit with the Trustee (or other Paying Agent appointed by the Company or if the Company is acting as its own Paying Agent, set aside, segregate and hold in trust as
provided in Section 10.03) an amount of money sufficient to repurchase on the Fundamental Change Repurchase Date all of the Notes to be repurchased on such date at the Fundamental Change Repurchase Price. Subject to receipt of funds and/or
Notes by the Trustee (or other Paying Agent appointed by the Company), payment for Notes surrendered for repurchase (and not withdrawn) prior to the Fundamental Change Expiration Time shall be made promptly after the later of (x) the
Fundamental Change Repurchase Date with respect to such Note (provided the Holder has satisfied the conditions to the payment of the Fundamental Change Repurchase Price in this Section 14.01), and (y) the time of book-entry transfer
or the delivery of such Note to the Trustee (or other Paying Agent appointed by the Company) by the Holder thereof in the manner required by this Section 14.01 by mailing checks for the amount payable to the Holders of such Notes entitled
thereto as they shall appear in the Register; provided, however, that payments to the Depositary shall be made by wire transfer of immediately available funds to the account of the Depositary or its nominee. The Trustee shall, promptly
after such payment and upon written demand by the Company, return to the Company any funds in excess of the Fundamental Change Repurchase Price. 
 (e) If the Trustee (or other Paying Agent appointed by the Company) holds money sufficient to repurchase on the Fundamental Change Repurchase Date all the Notes or portions thereof that are to be purchased as of the Business Day following
the Fundamental Change Repurchase Date, then on and after the Fundamental Change Repurchase Date (i) such Notes shall cease to be outstanding, (ii) interest shall cease to accrue on such Notes, and (iii) all other rights of the
Holders of such Notes shall terminate, whether or not book-entry transfer of the Notes has been made or the Notes have been delivered to the Trustee or Paying Agent, other than the right to receive the Fundamental Change Repurchase Price upon
delivery or transfer of the Notes. 
  

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 This instrument may be executed in any number of
counterparts, each of which so executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument. 
  

 73 

 IN WITNESS WHEREOF, the parties hereto have caused this First Supplemental Indenture to be duly executed
all as of the day and year first above written. 
  

			
	VIROPHARMA INCORPORATED
		
	By:	 	 /s/ Michel de Rosen

	Name:	 	Michel de Rosen
	Title:	 	President, CEO and Chairman
	
	WILMINGTON TRUST COMPANY, as Trustee
		
	By:	 	 /s/ Michael G. Oiler, Jr.

	Name:	 	Michael G. Oiler, Jr.
	Title:	 	Senior Financial Services Officer

 SCHEDULE A 
 The following table sets forth the “Stock Price,” “Effective Date” and number of Additional Shares by which the Conversion Rate for the 2.00% Convertible Senior Notes due 2017 shall be increased in
the event of a Fundamental Change: 
  

																																	
	 Effective Date
	  	Stock Price
		  	$	14.24	  	$	15.00	  	$	17.50	  	$	20.00	  	$	25.00	  	$	30.00	  	$	40.00	  	$	50.00	  	$	75.00	  	$	100.00	  	150.00
												
	 March 26, 2007
	  	 	17.2249	  	 	15.8857	  	 	12.4616	  	 	10.0654	  	 	6.9982	  	 	5.1667	  	 	3.1545	  	 	2.1133	  	 	0.9481	  	 	0.4802	  	0.1253
												
	 March 15, 2008
	  	 	17.2249	  	 	15.9578	  	 	12.4198	  	 	9.9612	  	 	6.8444	  	 	5.0065	  	 	3.0171	  	 	2.0047	  	 	0.8887	  	 	0.4450	  	0.1071
												
	 March 15, 2009
	  	 	17.2249	  	 	15.9016	  	 	12.2588	  	 	9.7488	  	 	6.6044	  	 	4.7792	  	 	28402	  	 	1.8739	  	 	0.8291	  	 	0.4192	  	0.1069
												
	 March 15, 2010
	  	 	17.2249	  	 	15.8082	  	 	12.0444	  	 	9.4768	  	 	6.3062	  	 	4.5011	  	 	2.6277	  	 	1.7181	  	 	0.7582	  	 	0.3880	  	0.1052
												
	 March 15, 2011
	  	 	17.2249	  	 	15.6709	  	 	11.7635	  	 	9.1301	  	 	5.9357	  	 	4.1612	  	 	2.3739	  	 	1.5345	  	 	0.6739	  	 	0.3491	  	0.1047
												
	 March 15, 2012
	  	 	17.0992	  	 	15.4766	  	 	11.3892	  	 	8.7049	  	 	5.4921	  	 	3.7517	  	 	2.0924	  	 	1.3410	  	 	0.5815	  	 	0.3187	  	0.1055
												
	 March 15, 2013
	  	 	17.0016	  	 	15.2404	  	 	10.9205	  	 	8.1066	  	 	4,8704	  	 	3.2068	  	 	1.6871	  	 	1.0466	  	 	0.4379	  	 	0.2112	  	0.0371
												
	 March 15, 2014
	  	 	16.8410	  	 	14.9306	  	 	10.3052	  	 	7.3692	  	 	4.1369	  	 	2.5842	  	 	1.2849	  	 	0.7870	  	 	0.3351	  	 	0.1635	  	0.0287
												
	 March 15, 2015
	  	 	16.6455	  	 	14.5118	  	 	9.4350	  	 	6.3349	  	 	3.1577	  	 	1.8027	  	 	0.8315	  	 	0.5121	  	 	0.2279	  	 	0.1098	  	0.0133
												
	 March 15, 2016
	  	 	16.3171	  	 	13.7926	  	 	7.9384	  	 	4.6223	  	 	1.7382	  	 	0.8287	  	 	0.3764	  	 	0.2544	  	 	0.1255	  	 	0.0629	  	0.0024
												
	 March 15, 2017
	  	 	17.2249	  	 	13.6669	  	 	4.1431	  	 	0.0000	  	 	0,0000	  	 	0.0000	  	 	0.0000	  	 	0.0000	  	 	0.0000	  	 	0.0000	  	0.0000

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