Document:

EX-4.4

 Exhibit 4.4 

THIRD SUPPLEMENTAL INDENTURE 

This Third Supplemental Indenture (the “Supplemental Indenture”), is dated as of September 28, 2012, among TTC
Acquisition Corporation and The Tar Heel Trading Company, LLC (each a “Guaranteeing Subsidiary” and collectively, the “Guaranteeing Subsidiaries”), each a subsidiary of IMS Health Incorporated, a Delaware
corporation (the “Issuer”), and U.S. Bank National Association, as trustee (the “Trustee”). 
 W I T N E S
S E T H 
 WHEREAS, each of the Issuer, and the Guarantors (as defined in the Indenture referred to below) has heretofore executed and
delivered to the Trustee an indenture (the “Indenture”), dated as of February 26, 2010, providing for the issuance of up to $1,000,000,000 aggregate principal amount of 12 1⁄2% Senior Notes due 2018 (the “Notes”); 
 WHEREAS, the Indenture provides that under
certain circumstances the Guaranteeing Subsidiaries shall execute and deliver to the Trustee a supplemental indenture pursuant to which each Guaranteeing Subsidiary shall unconditionally guarantee all of the Issuer’s Obligations under the Notes
and the Indenture on the terms and conditions set forth herein and under the Indenture (the “Guarantee”); and 
 WHEREAS,
pursuant to Section 9.01 of the Indenture, the Trustee is authorized to execute and deliver this Supplemental Indenture. 
 NOW
THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby acknowledged, the parties mutually covenant and agree for the equal and ratable benefit of the Holders of the Notes as
follows: 
 (1) Capitalized Terms. Capitalized terms used herein without definition shall have the meanings assigned to them in the
Indenture. 
 (2) Agreement to Guarantee. Each Guaranteeing Subsidiary hereby agrees as follows: 

(a) Along with all Guarantors named in the Indenture, subject to Article 11, to jointly and severally unconditionally guarantee
to each Holder of a Note authenticated and delivered by the Trustee and to the Trustee and its successors and assigns, irrespective of the validity and enforceability of the Indenture, the Notes or the obligations of the Issuer hereunder or under
the Indenture, that: 
 (i) the principal of and interest and Special Interest, if any, premium, if any, on the Notes will be
promptly paid in full when due, whether at maturity, by acceleration, redemption or otherwise, and interest on the overdue principal of and interest on the Notes, if any, if lawful, and all other Obligations of the Issuer to the Holders or the
Trustee hereunder or thereunder will be promptly paid in full or performed, all in accordance with the terms hereof and thereof; and 

(ii) in case of any extension of time of payment or renewal of any Notes or any of such other obligations, that same will be
promptly paid in full when due or performed in accordance with the terms of the extension or renewal, whether at stated maturity, by acceleration or otherwise. Failing payment by the Issuer when due of any amount

 
so guaranteed or any performance so guaranteed for whatever reason, the Guarantors and each Guaranteeing Subsidiary shall be jointly and severally obligated to pay the same immediately. This is a
guarantee of payment and not a guarantee of collection. 
 (b) The obligations hereunder shall be unconditional, irrespective
of the validity, regularity or enforceability of the Notes or the Indenture, the absence of any action to enforce the same, any waiver or consent by any Holder of the Notes with respect to any provisions hereof or thereof, the recovery of any
judgment against the Issuer, any action to enforce the same or any other circumstance which might otherwise constitute a legal or equitable discharge or defense of a guarantor (other than payment in full of all of the Obligations of the Issuer
hereunder and under the Indenture). 
 (c) The following is hereby waived to the fullest extent permitted by law: diligence,
presentment, demand of payment, filing of claims with a court in the event of insolvency or bankruptcy of the Issuer, any right to require a proceeding first against the Issuer, protest, notice and all demands whatsoever. 

(d) This Guarantee shall not be discharged except by complete performance of the obligations contained in the Notes, the
Indenture and this Supplemental Indenture or by release in accordance with the provisions of this Indenture, and each Guaranteeing Subsidiary accepts all obligations of a Guarantor under the Indenture. 

(e) If any Holder or the Trustee is required by any court or otherwise to return to the Issuer, the Guarantors (including each
Guaranteeing Subsidiary), or any custodian, trustee, liquidator or other similar official acting in relation to either the Issuer or the Guarantors, any amount paid either to the Trustee or such Holder, then this Guarantee, to the extent theretofore
discharged, shall be reinstated in full force and effect. 
 (f) The Guaranteeing Subsidiaries shall not be entitled to any
right of subrogation in relation to the Holders in respect of any obligations guaranteed hereby until payment in full of all obligations guaranteed hereby. 

(g) As between each Guaranteeing Subsidiary, on the one hand, and the Holders and the Trustee, on the other hand, (x) the
maturity of the obligations guaranteed hereby may be accelerated as provided in Article 6 of the Indenture for the purposes of this Guarantee, notwithstanding any stay, injunction or other prohibition preventing such acceleration in respect of the
obligations guaranteed hereby, and (y) in the event of any declaration of acceleration of such obligations as provided in Article 6 of the Indenture, such obligations (whether or not due and payable) shall forthwith become due and payable by
the Guaranteeing Subsidiaries for the purpose of this Guarantee. 
 (h) The Guaranteeing Subsidiaries shall have the right to
seek contribution from any non-paying Guarantor so long as the exercise of such right does not impair the rights of the Holders under this Guarantee. 

(i) Pursuant to Section 11.02 of the Indenture, after giving effect to all other contingent and fixed liabilities that are
relevant under any Bankruptcy Law, the Uniform Fraudulent Conveyance Act, the Uniform Fraudulent Transfer Act or any similar federal or state law to the extent that any of the foregoing are applicable to this Guarantee, and after giving effect to
any collections from, rights to receive contribution from or payments made by or on behalf of any other Guarantor in respect of the obligations of such other Guarantor under Article 11 of the Indenture,

 
this new Guarantee shall be limited to the maximum amount permissible such that the obligations of such Guaranteeing Subsidiaries under this Guarantee will not constitute a fraudulent transfer or
conveyance for purposes of such laws. 
 (j) This Guarantee shall remain in full force and effect and continue to be
effective should any petition be filed by or against the Issuer for liquidation, reorganization, should the Issuer become insolvent or make an assignment for the benefit of creditors or should a receiver or trustee be appointed for all or any
significant part of the Issuer’s assets, and shall, to the fullest extent permitted by law, continue to be effective or be reinstated, as the case may be, if at any time payment and performance of the Notes are, pursuant to applicable law,
rescinded or reduced in amount, or must otherwise be restored or returned by any obligee on the Notes and Guarantee, whether as a “voidable preference”, “fraudulent transfer” or otherwise, all as though such payment or
performance had not been made. In the event that any payment or any part thereof, is rescinded, reduced, restored or returned, the Note shall, to the fullest extent permitted by law, be reinstated and deemed reduced only by such amount paid and not
so rescinded, reduced, restored or returned. 
 (k) In case any provision of this Guarantee shall be invalid, illegal or
unenforceable, the validity, legality, and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

(l) This Guarantee shall be a general unsecured senior obligation of such Guaranteeing Subsidiaries. 

(m) Each payment to be made by each Guaranteeing Subsidiary in respect of this Guarantee shall be made without set-off,
counterclaim, reduction or diminution of any kind or nature. 
 (3) Execution and Delivery. Each Guaranteeing Subsidiary agrees that
the Guarantee shall remain in full force and effect notwithstanding the absence of the endorsement of any notation of such Guarantee on the Notes. 

(4) Merger, Consolidation or Sale of All or Substantially All Assets. 

(a) Except as otherwise provided in Section 5.01(c) of the Indenture, the Guaranteeing Subsidiaries may not consolidate or merge with or
into or wind up into (whether or not the Issuer or such Guaranteeing Subsidiary is the surviving corporation), or sell, assign, transfer, lease, convey or otherwise dispose of all or substantially all of its properties or assets, in one or more
related transactions, to any Person unless: 
 (i) (A) such Guaranteeing Subsidiary is the surviving entity or the
Person formed by or surviving any such consolidation or merger (if other than such Guaranteeing Subsidiary) or to which such sale, assignment, transfer, lease, conveyance or other disposition will have been made is a Person organized or existing
under the laws of the jurisdiction of organization of such Guaranteeing Subsidiary, as the case may be, or the laws of the United States, any state thereof, the District of Columbia, or any territory thereof (such Guaranteeing Subsidiary or such
Person, as the case may be, being herein called the “Successor Person”); 
 (B) the Successor Person, if
other than such Guaranteeing Subsidiary, expressly assumes all the obligations of such Guaranteeing Subsidiary under the Indenture and such Guaranteeing Subsidiary’s related Guarantee pursuant to supplemental indentures or other documents or
instruments in form reasonably satisfactory to the Trustee; 

 (C) immediately after such transaction, no Default exists; and 

(D) the Issuer shall have delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that
such consolidation, merger or transfer and such supplemental indentures, if any, comply with the Indenture; or 
 (ii) the
transaction is made in compliance with clauses (1) and (2) of Section 4.10(a) of the Indenture; 
 (b) In the case of section
(a)(i) of this Section 4, the Successor Person will succeed to, and be substituted for, such Guaranteeing Subsidiary under the Indenture and such Guaranteeing Subsidiary’s Guarantee. Notwithstanding the foregoing, such Guaranteeing
Subsidiary may (1) merge or consolidate with or into or wind up into or transfer all or part of its properties and assets to another Guarantor or the Issuer, (2) merge with a Restricted Subsidiary of the Issuer solely for the purpose of
reincorporating such Guaranteeing Subsidiary in the United States, any state thereof, the District of Columbia or any territory thereof or (3) convert into a corporation, partnership, limited partnership, limited liability corporation or trust
organized or existing under the laws of the jurisdiction of organization of such Guaranteeing Subsidiary, in each case without complying with section (a) of this Section 4. 

(5) Releases. The Guarantee of a Guaranteeing Subsidiary shall be automatically and unconditionally released and discharged, and no
further action by such Guaranteeing Subsidiary, the Issuer or the Trustee is required for the release of such Guaranteeing Subsidiary’s Guarantee, upon: 

(1) (A) any sale, exchange, disposition or transfer (by merger, consolidation, amalgamation or otherwise) of the Capital Stock
of such Guaranteeing Subsidiary, after which such Guaranteeing Subsidiary is no longer a Restricted Subsidiary or all or substantially all the assets of such Guaranteeing Subsidiary which sale, exchange, disposition or transfer is made in compliance
with Sections 4.10(a)(1) and (2) of the Indenture; 
 (B) the release or discharge of the guarantee by such Guaranteeing
Subsidiary of Indebtedness under the Credit Agreement or such other guarantee which resulted in the creation of the Guarantee, except a discharge or release by or as a result of payment under such guarantee (it being understood that a release
subject to a contingent reinstatement is still a release, and that if any such guarantee is so reinstated, this Guarantee shall also be reinstated to the extent that such Guaranteeing Subsidiary would then be required to provide a Guarantee pursuant
to Section 4.15 of the Indenture); 
 (C) the designation of such Guaranteeing Subsidiary as an Unrestricted Subsidiary
in compliance with Section 4.07(c) of the Indenture; or 
 (D) the Issuer exercising its Legal Defeasance option or
Covenant Defeasance option in accordance with Article 8 of the Indenture or the Issuer’s obligations under the Indenture being discharged in accordance with Article 13 of the Indenture; and 

(2) delivery by such Guaranteeing Subsidiary to the Trustee of an Officer’s Certificate and an Opinion of Counsel, each
stating that all conditions precedent provided for in the Indenture relating to such transaction have been complied with. 

 (6) No Recourse Against Others. No past, present or future director, officer, employee,
incorporator, member, partner or stockholder of the Guaranteeing Subsidiaries or any of their direct or indirect parent companies shall have any liability for any obligations of the Issuer or the Guarantors (including the Guaranteeing Subsidiaries)
under the Notes, any Guarantees, the Indenture or this Supplemental Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder by accepting Notes waives and releases all such liability. The
waiver and release are part of the consideration for issuance of the Notes. 
 (7) Governing Law. THIS SUPPLEMENTAL INDENTURE WILL BE
GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 (8) Counterparts. The parties may sign any number
of copies of this Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. 

(9) Effect of Headings. The Section headings herein are for convenience only, are not to be considered part of this Supplemental
Indenture and shall in no way modify or restrict any of the terms or provisions hereof. 
 (10) The Trustee. The Trustee shall not be
responsible for and makes no representation as to the validity or adequacy of this Supplemental Indenture and it shall not be responsible for any the recitals contained herein. 

(11) Subrogation. Each Guaranteeing Subsidiary shall be subrogated to all rights of Holders of Notes against the Issuer in respect of
any amounts paid by the Guaranteeing Subsidiaries pursuant to the provisions of Section 2 hereof and Section 11.01 of the Indenture; provided that, if an Event of Default has occurred and is continuing, the Guaranteeing Subsidiaries
shall not be entitled to enforce or receive any payments arising out of, or based upon, such right of subrogation until all amounts then due and payable by the Issuer under the Indenture or the Notes shall have been paid in full. 

(12) Benefits Acknowledged. Each Guaranteeing Subsidiary’s Guarantee is subject to the terms and conditions set forth in the
Indenture. Each Guaranteeing Subsidiary acknowledges that it will receive direct and indirect benefits from the financing arrangements contemplated by the Indenture and this Supplemental Indenture and that the guarantee and waivers made by it
pursuant to this Guarantee are knowingly made in contemplation of such benefits. 
 (13) Successors. All agreements of each
Guaranteeing Subsidiary in this Supplemental Indenture shall bind its Successors, except as otherwise provided in Section 2(k) or elsewhere in this Supplemental Indenture. All agreements of the Trustee in this Supplemental Indenture shall bind
its successors. 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed, all as of the date first above written. 
  

			
	U.S. BANK NATIONAL ASSOCIATION
	as Trustee
		
	By:	 	 /s/ Donald T. Hurrelbrink

	Name:	 	Donald T. Hurrelbrink
	Title:	 	Vice President
	
	 TTC ACQUISITION CORPORATION
 as
Subsidiary Guarantor

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	President and Treasurer
	
	 THE TAR HEEL TRADING COMPANY, LLC

as Subsidiary Guarantor

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	Vice President and Treasurer

 [Third Supplemental Indenture]EX-4.5

 Exhibit 4.5 

FOURTH SUPPLEMENTAL INDENTURE 

This Fourth Supplemental Indenture (the “Supplemental Indenture”) is dated as of October 24, 2012 among IMS Health
Incorporated, a Delaware corporation (the “Issuer”), the Guarantors listed on the signature pages hereto and U.S. Bank National Association, as Trustee (the “Trustee”). Capitalized terms not defined herein shall
have the meanings assigned to them in the Indenture (as defined below). 
 W I T N E S S E T H 

WHEREAS, the Issuer and the Trustee have previously become parties to an Indenture, dated as of February 26, 2010 (as amended,
supplemented or otherwise modified from time to time prior to the date hereof, the “Indenture”), providing for the issuance of the Issuer’s
12 1⁄2% Senior Notes due 2018; 
 WHEREAS, the
Issuer proposes to amend the Indenture and Notes as contemplated by this Supplemental Indenture (such amendments, collectively, the “Amendments”); 

WHEREAS, pursuant to Section 9.02 of the Indenture, the Issuer and the Trustee may amend or supplement the Indenture as contemplated by
this Supplemental Indenture with the consent of the Holders of at least a majority in aggregate principal amount of the outstanding Notes; 

WHEREAS, the Issuer has obtained the consent of the Holders of at least a majority in aggregate principal amount of the outstanding Notes,
pursuant to the Offering Circular and Consent Solicitation Statement, dated October 10, 2012 (as amended, supplemented or modified from time to time, the “Offering Circular”), to the Amendments upon the terms and subject to the
conditions set forth therein; 
 WHEREAS, each Holder who has validly tendered, or will validly tender, Notes for exchange in the Senior
Notes Exchange Offer contemplated by the Offering Circular has agreed, or will agree upon such valid tender, to waive its right to receive payment of all interest that has accrued from September 1, 2012 on such validly tendered Notes; 

WHEREAS, the Issuer has done all things necessary to make this Supplemental Indenture a valid agreement of the Issuer in accordance with the
terms of the Indenture and has satisfied all other conditions required under Article 9 of the Indenture; and 
 WHEREAS, pursuant to
Section 9.06, the Trustee is authorized to execute and deliver this Supplemental Indenture. 

 NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration,
the receipt of which is hereby acknowledged, in order to effect the Amendments, the parties hereto agree as follows: 
 Section 1. Amendments to the
Indenture. Following the execution and delivery by the Issuer, the Guarantors and the Trustee of this Supplemental Indenture, the Amendments shall become operative upon the initial acceptance for exchange by the Issuer of Notes validly tendered
in the Senior Notes Exchange Offer contemplated by the Offering Circular and the Issuer’s payment of the Participation Payment (as defined in the Offering Circular) on the Early Settlement Date (as defined in the Offering Circular) to the
exchange agent for distribution in respect of such tendered Notes in accordance with the terms of the Senior Notes Exchange Offer (the “Operative Time”). Effective as of the Operative Time, the Supplemental Indenture hereby amends
the Indenture and the Notes as follows: 
  

	 	(a)	The following definitions are hereby added to Section 1.01 of the Indenture: 

“2012 Transaction Expenses” means any fees or expenses incurred or paid by the Issuer or any Restricted
Subsidiary in connection with the 2012 Transactions, including payments to officers, employees and directors as change of control payments, severance payments, special or retention bonuses, if any, charges for repurchase or rollover of, or
modifications to, stock options and/or restricted stock and charges related to the crediting of additional restricted stock units. 

“2012 Transactions” means the transactions related or incidental to, consisting of or in connection with
(i) the issuance of the Senior Exchange Notes in the Senior Notes Exchange Offer, (ii) the borrowings under, and amendments to, the Credit Facilities and the issuance of the 2020 Notes, in each case, on the Initial Exchange Date,
(iii) the retirement of the Notes tendered in the Senior Notes Exchange Offer, (iv) the amendments to this Indenture on the Initial Exchange Date, (v) a one-time cash dividend in an amount up to $1,250.0 million made on or about the
Initial Exchange Date by the Issuer to Holdings (and by Holdings to its direct or indirect parents) and (vi) the payment of all fees and expenses associated with the foregoing, in each case, substantially as described in the Offering Circular.

 “2020 Notes” means the $500.0 million in aggregate principal amount of the Issuer’s Senior
Unsecured Notes due 2020. 
 “2020 Notes Indenture” means the Indenture for the 2020 Notes, dated on or
about the Initial Exchange Date among the Issuer, the guarantors party thereto and Wells Fargo Bank, National Association, as trustee, as amended, supplemented or modified from time to time. 

“Initial Exchange Date” means the “Early Settlement Date” as defined in the Offering Circular. 

“Offering Circular” means the Offering Circular and Consent Solicitation Statement of the Issuer dated as of
October 10, 2012, as amended, supplemented or modified from time to time. 

 “Senior Exchange Notes” means the up to $1,000.0 million in
aggregate principal amount of the Issuer’s 12 1⁄2% Senior Unsecured Exchange Notes due 2018 issued in exchange for the Notes pursuant to the Senior Notes
Exchange Offer. 
 “Senior Exchange Notes Indenture” means the Indenture for the Senior Exchange Notes,
dated on or about the Initial Exchange Date, among the Issuer, the guarantors party thereto and U.S. Bank National Association, as trustee, as amended, supplemented or modified from time to time. 

“Senior Notes Exchange Offer” means the offer to issue the Senior Exchange Notes in exchange for the Notes as
described in the Offering Circular. 
 “Total Assets” means the total assets of the Issuer and its
Restricted Subsidiaries, determined on a consolidated basis in accordance with GAAP, as shown on the most recent balance sheet of the Issuer or such other Person as may be expressly stated (and, in the case of any determination relating to any
incurrence of Indebtedness or any Investment or other acquisition, on a pro forma basis including any property or assets being acquired in connection therewith).” 

“Total Net Leverage Ratio” means, with respect to any specified Person on any Calculation Date, the ratio of
(1) the sum of (without duplication) (x) any Indebtedness of the Issuer or any of its Restricted Subsidiaries in respect of borrowed money, Capitalized Lease Obligations and debt obligations evidenced by promissory notes and similar
instruments less (y) the aggregate amount of unrestricted Cash Equivalents, in each case as of the end of the most recent fiscal quarter for which internal financial statements are available immediately preceding the Calculation Date, to
(2) EBITDA of such Person and its Restricted Subsidiaries for the most recently ended four fiscal quarters for which internal financial statements are available immediately preceding the Calculation Date, in each case on a pro forma basis with
such pro forma adjustments as are appropriate and consistent with the pro forma adjustment provisions set forth in the definition of Consolidated Secured Net Leverage Ratio. 
  

	 	(b)	Clause (d) of the definition of “Asset Sale” is hereby amended by replacing “$10,000,000” with “the greater of $75,000,000 and 1.0% of Total Assets”. 

 

	 	(c)	The definition of “Calculation Date” is hereby deleted in its entirety and replaced with the following: 

““Calculation Date” means the date on which the event for which the calculation of the Consolidated
Secured Net Leverage Ratio, the Total Net Leverage Ratio or the Fixed Charge Coverage Ratio, as applicable, shall occur.” 
  

	 	(d)	Clause (1) of the definition of “Consolidated Net Income” is hereby deleted in its entirety and replaced with the following: 

“any net after tax effect of extraordinary, nonrecurring or unusual gains or losses, costs, charges or expenses,
Transaction Expenses and 2012 Transaction Expenses shall be excluded,”. 

	 	(e)	The definition of “Consolidated Secured Leverage Ratio” is hereby deleted in its entirety and replaced with the following: 

““Consolidated Secured Net Leverage Ratio” means, with respect to any specified Person on any
Calculation Date, the ratio of (1) the sum of (without duplication) (w) the aggregate outstanding amount of Secured Indebtedness of such Person and its Restricted Subsidiaries (other than any Indebtedness of a Restricted Subsidiary which
is not a Guarantor which is not secured by any assets of the Issuer or a Guarantor), plus (x) the aggregate liquidation preference of all outstanding Disqualified Stock and Preferred Stock (except Disqualified Stock and Preferred Stock issued
to the Issuer or a Restricted Subsidiary) of such Person and its Restricted Subsidiaries secured by a Lien, plus (y) the aggregate outstanding amount of all Receivables Facilities established by or for such Person and its Restricted
Subsidiaries (and without regard to whether such facilities would be reflected on the consolidated balance sheet of such Person and its Restricted Subsidiaries) less (z) the aggregate amount of unrestricted Cash Equivalents, in each case as of
the end of the most recent fiscal quarter for which internal financial statements are available immediately preceding the Calculation Date to (2) the EBITDA of such Person and its Restricted Subsidiaries for the most recently ended four fiscal
quarters for which internal financial statements are available immediately preceding the Calculation Date. 
 In the event that the Issuer
or any Restricted Subsidiary incurs, assumes, guarantees, redeems, repays, retires or extinguishes any Indebtedness or issues or redeems Disqualified Stock or Preferred Stock during the period (the “Stub Period”) subsequent to the
end of the most recent fiscal quarter for which internal financial statements are available immediately preceding the Calculation Date, then the Consolidated Secured Net Leverage Ratio shall be calculated giving pro forma effect to such incurrence,
assumption, guarantee, redemption, repayment, retirement or extinguishment of Indebtedness, or such issuance or redemption of Disqualified Stock or Preferred Stock, as if the same had occurred on the last day of the applicable period; provided that
Indebtedness incurred or repaid under any revolving credit facility in the ordinary course of business for working capital purposes during the Stub Period shall be only be treated as having been incurred or repaid during such period if the average
daily balances of such Indebtedness during the Stub Period exceeds or is less than the amount of such Indebtedness outstanding as of the last day of the applicable period. 

For purposes of making the computation referred to above, Specified Transactions that have been made by the Issuer or any Restricted
Subsidiary during the four-quarter period ending on the last day of the reference period or subsequent to such reference period and on or prior to or simultaneously with the Calculation Date (a) shall be calculated in good faith by the Chief
Financial Officer of the Issuer on 

 
a pro forma basis assuming that all such Specified Transactions had occurred on the first day of the reference period and (b) in connection with any such Specified Transaction (other than,
for avoidance of doubt, the Transactions), there shall be given pro forma effect to (A) expected cost savings resulting therefrom permitted to be reflected in pro forma financial information with respect to any such Specified Transaction under
Rule 11.02 of Regulation S-X under the Securities Act and (B) additional cost savings that result or are expected to result from actions taken, committed to be taken or planned to be taken pursuant to a factually supported plan in connection
with any such Specified Transaction prior to the Calculation Date; provided, that such cost savings referred to in this clause (B) (x) are factually supportable and determined in good faith by the Issuer, as certified in an Officer’s
Certificate executed by the Chief Financial Officer of the Issuer to the Trustee and, prior to the Disposition Date, the GSMP Group, and (y) do not exceed the actual cost savings expected in good faith to be realized by the Issuer and its
Restricted Subsidiaries over such 12 month period commencing with the Calculation Date (as opposed, for the avoidance of doubt, to the annualized impact of such cost savings). If since the beginning of such period any Person that subsequently became
a Restricted Subsidiary or was merged with or into the Issuer or any Restricted Subsidiary since the beginning of such period shall have made any Specified Transaction that would have required adjustment pursuant to this definition, then the
Consolidated Secured Net Leverage Ratio shall be calculated giving pro forma effect thereto for such period as if such Specified Transaction had occurred at the beginning of the reference period. 

Any Person that is a Restricted Subsidiary on the Calculation Date will be deemed to have been a Restricted Subsidiary at all times during
such four-quarter period, and any Person that is not a Restricted Subsidiary on the Calculation Date will be deemed not to have been a Restricted Subsidiary at any time during such four-quarter period.” 

 

	 	(f)	All references in the Indenture to “Consolidated Secured Leverage Ratio” are hereby replaced with “Consolidated Secured Net Leverage Ratio”. 

 

	 	(g)	The definition of “Credit Agreement” is hereby deleted in its entirety and replaced with the following: 

““Credit Agreement” means that certain Second Amended and Restated Credit Agreement, dated on or about
the Initial Exchange Date, among IMS Health Incorporated, Holdings, the Restricted Subsidiaries party thereto, Bank of America, N.A., as Administrative Agent, and each other agent and lender from time to time party thereto, and any amendments,
supplements, modifications, extensions, renewals, restatements, refundings or refinancings thereof.” 

	 	(h)	The definition of “Designated Preferred Stock” is hereby deleted in its entirety and replaced with the following: 

““Designated Preferred Stock” means Preferred Stock of the Issuer, any of its Restricted Subsidiaries or
any direct or indirect parent company thereof (in each case other than Disqualified Stock) that is issued for cash (other than to a Restricted Subsidiary or an employee stock ownership plan or trust established by the Issuer or any of its
Subsidiaries) and is so designated as Designated Preferred Stock, pursuant to an Officer’s Certificate delivered to the Trustee on the issuance date thereof, the cash proceeds of which are excluded from the calculation set forth in clause
(3) of Section 4.07(a) hereof.” 
  

	 	(i)	The definition of “fair market value” is hereby deleted in its entirety and replaced with the following: 

““fair market value” means, with respect to any asset or liability, the fair market value of such asset
or liability as determined by the Issuer in good faith.” 
  

	 	(j)	The definition of “Incremental Facilities” is hereby deleted in its entirety. 

  

	 	(k)	Clause (1) of the definition of “Permitted Investments” is hereby deleted in its entirety and replaced with the following: 

“any Investment in the Issuer or any of its Restricted Subsidiaries;”. 

 

	 	(l)	Clause (3) of the definition of “Permitted Investments” is hereby deleted in its entirety and replaced with the following: 

“any Investment by the Issuer or any of its Restricted Subsidiaries in a Person that is engaged (directly or through
entities that will be Restricted Subsidiaries) in a Similar Business if as a result of such Investment: 
 (a) such Person
becomes a Restricted Subsidiary; or 
 (b) such Person, in one transaction or a series of related transactions, is
amalgamated, merged or consolidated with or into, or transfers or conveys substantially all of its assets to, or is liquidated into, the Issuer or a Restricted Subsidiary, 

and, in each case, any Investment held by such Person; provided, that such Investment was not acquired by such Person in contemplation of such
acquisition, merger, amalgamation, consolidation or transfer;”. 
  

	 	(m)	Clause (11) of the definition of “Permitted Investments” is hereby amended by replacing “$150,000,000” with “the greater of $225,000,000 and 3.00% of Total Assets”. 

 

	 	(n)	Clause (12) of the definition of “Permitted Investments” is hereby amended by replacing “$10,000,000” with “$25,000,000”. 

 

	 	(o)	Clause (15) of the definition of “Permitted Investments” is hereby amended by replacing “; and” with “;”. 

	 	(p)	Clause (16) of the definition of “Permitted Investments” is hereby amended by replacing “.” with “;”. 

 

	 	(q)	The definition of “Permitted Investments” is hereby amended by adding the following new clauses after clause (16): 

(17) any Investment in a Similar Business taken together with all other Investments made pursuant to this clause
(17) that are at that time outstanding, not to exceed the greater of (a) $200,000,000 and (b) 2.5% of Total Assets (with the amount of each Investment being measured at the time made and without giving effect to subsequent changes in
value, but subject to adjustment as set forth in the definition of Investment); and 
 (18) Investments in Unrestricted
Subsidiaries, taken together with all other Permitted Investments made pursuant to this clause (18) that are at the time outstanding, without giving effect to the sale of an Unrestricted Subsidiary to the extent the proceeds of such sale do not
consist of, or have not been subsequently sold or transferred for, Cash Equivalents or marketable securities, not to exceed the greater of (a) $150,000,000 and (b) 2.0% of Total Assets (with the amount of each Investment being measured at
the time made and without giving effect to subsequent changes in value, but subject to adjustment as set forth in the definition of Investment). 
  

	 	(r)	Clause (8) of the definition of “Permitted Liens” is hereby deleted in its entirety and replaced with the following: 

“Liens on property or shares of stock of a Person at the time such Person becomes a Restricted Subsidiary; provided,
however, that (i) such Liens are not created or incurred in connection with, or in contemplation of, such other Person becoming such a Subsidiary; (ii) such Liens may not extend to any other property owned by the Issuer or any of its
Restricted Subsidiaries, and (iii) immediately after giving effect to such Person becoming a Restricted Subsidiary the Consolidated Secured Net Leverage Ratio on a consolidated basis for the Issuer and its Restricted Subsidiaries’ most
recently ended four fiscal quarters for which internal financial statements are available is either (x) not greater than 3.50 to 1.00 or (y) lower than such Consolidated Secured Net Leverage Ratio immediately prior to such transaction (the
“Secured Net Leverage Ratio Test”);” 
  

	 	(s)	Clause (9) of the definition of “Permitted Liens” is hereby amended by replacing “Secured Leverage Ratio Test” with “Secured Net Leverage Ratio Test”. 

 

	 	(t)	Clause (18) of the definition of “Permitted Liens” is hereby amended by replacing “$50,000,000” with “the greater of $125,000,000 and 1.75% of Total Assets”. 

 

	 	(u)	The definition of “Registration Rights Agreement” is hereby deleted in its entirety and replaced with the following: 

““Registration Rights Agreement” means the Amended and Restated Exchange and Registration Rights
Agreement, dated as of the Initial Exchange Date, 

 
by and among the Issuer and the other parties named on the signature pages thereof, and with respect to any Additional Notes, one or more registration rights agreements between the Issuer and the
other parties thereto, as such agreements may be amended, modified or supplemented from time to time relating to rights given by the Issuer to the purchasers of Notes or Additional Notes, as applicable, to register such Notes or Additional Notes, as
applicable, under the Securities Act.” 
  

	 	(v)	Section 4.07(a)(3) of the Indenture is hereby amended by replacing “clauses (2), (3), (4), (5), (6), (7), (9), (10), (11), (13) and (14)” with “clauses (2), (3), (4), (5), (6), (7), (9), (10),
(11), (12), (13), (14) and (15)”. 

  

	 	(w)	The first paragraph of Section 4.07(b)(4) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“a Restricted Payment to pay for the repurchase, retirement or other acquisition or retirement for value of Equity
Interests (other than Disqualified Stock) of the Issuer or any of its direct or indirect parent companies held by any future, present or former employee, director, officer or consultant (or their respective Controlled Investment Affiliates or
Immediate Family Members) of the Issuer or any of its Restricted Subsidiaries or any direct or indirect parent companies pursuant to any management equity plan or stock option plan or any other management or employee benefit plan or agreement
(including, for the avoidance of doubt, any principal and interest payable on any notes issued by the Issuer or any direct or indirect parent company of the Issuer in connection with any such repurchase, retirement or other acquisition), or any
stock subscription or shareholder agreement, including any Equity Interest rolled over by management of the Issuer or any direct or indirect parent company of the Issuer in connection with the Transactions; provided, however, that the
aggregate amount of Restricted Payments made under this clause (4) shall not exceed in any calendar year $50,000,000 (which shall increase to $75,000,000 subsequent to the consummation of a Qualified Public Offering) (with unused amounts for
any year being carried over to the succeeding two years); provided further that such amount in any calendar year may be increased by an amount not to exceed:” 

 

	 	(x)	Section 4.07(b)(10) of the Indenture is hereby amended by replacing “not to exceed $100,000,000” with “not to exceed the greater of $150,000,000 and 2.0% of Total Assets”. 

 

	 	(y)	Section 4.07(b)(11) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“any Restricted Payment used to fund (or otherwise made in connection with) the Transactions or the 2012 Transactions, in
each case, to the extent permitted by Section 4.11 hereof;” 
  

	 	(z)	Section 4.07(b)(14)(e) of the Indenture is hereby amended by replacing “.” with “; and”. 

	 	(aa)	Section 4.07(b) of the Indenture is hereby amended by adding the following new clause (15): 

“(15) Restricted Payments, provided that, after giving pro forma effect thereto and the application of the
net proceeds therefrom, the Total Net Leverage Ratio for the most recently ended four fiscal quarters for which internal financial statements are available immediately preceding such Restricted Payment would be no greater than 4.00 to 1.00;”

  

	 	(bb)	The proviso at the end of Section 4.07(b) of the Indenture is hereby amended by replacing “clauses (10) and (12)” with “clauses (10), (12) and (15)”. 

 

	 	(cc)	Section 4.08(b)(2) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“contractual restrictions contained in (A) the Indenture, the Notes and Guarantees, (B) the Senior Exchange
Notes Indenture, the Senior Exchange Notes and guarantees thereof and (C) the 2020 Notes Indenture, the 2020 Notes and guarantees thereof;” 
  

	 	(dd)	Section 4.09(a) of the Indenture is hereby amended by (1) replacing “$125,000,000” with “the greater of $175,000,000 and 2.25% of Total Assets” and (2) deleting each reference to
“or Attributable Debt” therein. 

  

	 	(ee)	Section 4.09(b)(1) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“the incurrence of Indebtedness under Credit Facilities by the Issuer and, subject to the proviso in this clause
(1) below, any Restricted Subsidiary of the Issuer, and the issuance and creation of letters of credit and bankers’ acceptances thereunder (with letters of credit and bankers’ acceptances being deemed to have a principal amount equal
to the face amount thereof), in an aggregate principal amount that, together with the aggregate amount of Receivables Facilities incurred pursuant to clause 4.09(b)(12) below, does not exceed at any one time outstanding the sum of $3,525,000,000
plus, in the event of any extension, replacement, refinancing, renewal or defeasance of any such Credit Facility an amount equal to the amount of any penalty or premium required to be paid under the terms of the instrument or documents governing
such Credit Facility and any defeasance costs and any fees and expenses (including original issue discount, upfront fees or similar fees) incurred in connection with the issuance of such new Indebtedness or the extension, replacement, refunding,
refinancing, renewal or defeasance of such Credit Facility;” 
  

	 	(ff)	Section 4.09(b)(2) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“the incurrence by (a) the Issuer of Indebtedness represented by the Notes in an aggregate principal amount not
exceeding the Senior Unsecured Note Cap and any exchange notes to be issued in exchange for the Notes, (b) the Issuer of Indebtedness represented by the Senior Exchange Notes and any exchange notes

 
to be issued in exchange for the Senior Exchange Notes, (c) the Issuer of Indebtedness represented by the 2020 Notes, and (d) any Subsidiary Guarantor of any guarantee of any
Indebtedness referred to in the foregoing clauses (2)(a), (b) or (c); 
  

	 	(gg)	Section 4.09(b)(4) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“Indebtedness (including Capitalized Lease Obligations) and Disqualified Stock incurred or issued by the Issuer or any
Restricted Subsidiary and Preferred Stock issued by any Restricted Subsidiary, to finance the purchase, lease, replacement or improvement of property (real or personal), equipment or other assets, whether through the direct purchase of assets or the
Capital Stock of any Person owning such assets in an aggregate principal amount, together with any Refinancing Indebtedness in respect thereof and all other Indebtedness, Disqualified Stock and/or Preferred Stock incurred or issued and outstanding
under this clause (4) at such time, not to exceed the greater of (x) $150,000,000 and (y) 2.0% of Total Assets (in each case, determined at the date of incurrence or issuance), so long as such Indebtedness, Disqualified Stock or
Preferred Stock is incurred or issued at the date of such purchase, lease, replacement or improvement or within 270 days thereafter;” 
  

	 	(hh)	Section 4.09(b)(7) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“Indebtedness of the Issuer to a Restricted Subsidiary; provided that (i) any such Indebtedness to a
Restricted Subsidiary that is not a Guarantor is expressly subordinated in right of payment to the Notes and (ii) any subsequent issuance or transfer of any Capital Stock or any other event which results in any Restricted Subsidiary ceasing to
be a Restricted Subsidiary or any other subsequent transfer of any such Indebtedness (except to the Issuer or another Restricted Subsidiary, or any collateral agent under the Credit Facilities) shall be deemed, in each case, to be an incurrence of
such Indebtedness not permitted by this clause (7);” 
  

	 	(ii)	Section 4.09(b)(8) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“Indebtedness of a Restricted Subsidiary to the Issuer or another Restricted Subsidiary; provided that if a
Subsidiary Guarantor incurs such Indebtedness to a Restricted Subsidiary that is not a Subsidiary Guarantor, such Indebtedness is expressly subordinated in right of payment to the Guarantee of the Notes of such Subsidiary Guarantor; provided
further that any subsequent transfer of any such Indebtedness (except to the Issuer or another Restricted Subsidiary, or any collateral agent under the Credit Facilities) shall be deemed, in each case, to be an incurrence of such Indebtedness
not permitted by this clause (8);” 

	 	(jj)	Section 4.09(b)(9) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“shares of Preferred Stock of a Restricted Subsidiary issued to the Issuer or another Restricted Subsidiary,
provided that any subsequent issuance or transfer of any Capital Stock or any other event which results in any such Restricted Subsidiary ceasing to be a Restricted Subsidiary or any other subsequent transfer of any such shares of Preferred
Stock (except to the Issuer or another of its Restricted Subsidiaries) shall be deemed in each case to be an issuance of such shares of Preferred Stock not permitted by this clause (9);” 

 

	 	(kk)	The first paragraph of Section 4.09(b)(13) is hereby amended by (1) replacing “clauses (2), (3), (4), (13) and (19)” with “clauses (2), (3), (4), (13), (19) and (24)” and
(2) deleting “(including Attributable Debt)” in its entirety. 

  

	 	(ll)	Section 4.09(b)(13)(A) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“has a final maturity date equal to or later than the final maturity date of, and has a Weighted Average Life to Maturity
at the time such Refinancing Indebtedness is incurred which is not less than the remaining Weighted Average Life to Maturity of, the Indebtedness, Disqualified Stock or Preferred Stock being extended, replaced, renewed, defeased, refunded or
refinanced; provided that such Refinancing Indebtedness may be incurred in the form of a customary “bridge” or other interim credit facility intended to be refinanced or replaced with long-term Indebtedness which does not satisfy the
requirements of this clause (A) so long as, subject to customary conditions, such Refinancing Indebtedness would either be automatically converted into or required to be exchanged for permanent financing which satisfies the requirements of this
clause (A),” 
  

	 	(mm)	Section 4.09(b)(14) of the Indenture is hereby amended by replacing “$50,000,000” with “the greater of $125,000,000 and 1.75% of Total Assets”. 

 

	 	(nn)	Section 4.09(b)(19) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“(a) Indebtedness or Disqualified Stock of the Issuer or Indebtedness, Disqualified Stock or Preferred Stock of a
Restricted Subsidiary, incurred or issued to finance an acquisition (or other purchase of assets) or that is assumed by the Issuer or any Restricted Subsidiary in connection with such acquisition or (b) Indebtedness, Disqualified Stock or
Preferred Stock of Persons that are acquired by the Issuer or any Restricted Subsidiary or merged into, amalgamated or consolidated with the Issuer or a Restricted Subsidiary in accordance with the terms of the Indenture; provided, that after giving
effect to such acquisition, amalgamation, consolidation or merger, either: 
 (i) the Issuer would be permitted to incur at
least $1.00 of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio Test, or 
 (ii) the Fixed Charge
Coverage Ratio for the Issuer is equal to or greater than immediately prior to such acquisition, amalgamation, consolidation or merger;” 

	 	(oo)	Section 4.09(b)(20) of the Indenture is hereby amended by replacing (1) “the Subsidiary Guarantors” with “its Restricted Subsidiaries” and (2) “$250,000,000” with “the
greater of $300,000,000 and 3.75% of Total Assets”. 

  

	 	(pp)	Section 4.09(b)(22) hereby amended by replacing “; and” with “;”. 

  

	 	(qq)	Section 4.09(b)(23) hereby amended by replacing “.” with “; and”. 

  

	 	(rr)	Section 4.09(b) hereby amended by adding the following new clause after clause (23): 

“(24) Indebtedness or Disqualified Stock of the Issuer and Indebtedness, Disqualified Stock or Preferred Stock of the
Issuer or any Restricted Subsidiary in an aggregate principal amount or liquidation preference up to 100.0% of the net cash proceeds received by the Issuer since immediately after the Issue Date from the issue or sale of Equity Interests of the
Issuer or cash contributed to the capital of the Issuer (in each case, other than proceeds of Disqualified Stock or sales of Equity Interests to the Issuer or any of its Subsidiaries) as determined in accordance with clauses (3)(B) and
(3)(C) of Section 4.07(a) to the extent such net cash proceeds or cash have not been applied pursuant to such clauses to make Restricted Payments pursuant to Section 4.07(b) or to make Permitted Investments (other than Permitted
Investments specified in clause (1), (2) or (3) of the definition thereof).” 
  

	 	(ss)	Section 4.09(c)(1) is hereby amended by (1) replacing “clauses (1) through (23)” with “clauses (1) through (24)” and (2) deleting “(and, for the avoidance of doubt, the
Issuer, in its sole discretion, may reclassify any Attributable Debt incurred pursuant to clause (4) of Section 4.09(b) as incurred pursuant to Section 4.09(a) at any time such incurrence is permitted)” in its entirety.

  

	 	(tt)	Section 4.10(a)(2)(C) of the Indenture is hereby amended by replacing “$75,000,000 and 3% of Net Tangible Assets” with “$175,000,000 and 2.25% of Total Assets”. 

 

	 	(uu)	Section 4.10(c) of the Indenture is hereby amended by replacing each occurrence of “$25,000,000” with “$125,000,000”. 

 

	 	(vv)	Section 4.11(a) of the Indenture is hereby amended by replacing “$2,000,000” with “$25,000,000”. 

  

	 	(ww)	Section 4.11(a)(2)(A) of the Indenture is hereby amended by replacing “$15,000,000” with “$75,000,000”. 

  

	 	(xx)	Section 4.11(a)(2)(B) of the Indenture is hereby deleted in its entirety and replaced with “[Reserved].”. 

	 	(yy)	Section 4.11(b)(4) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“(A) the Transaction and the payment of all reasonable fees and expenses related to the Transaction, including Transaction
Expenses and (B) the 2012 Transactions and the payment of all reasonable fees and expenses related to the 2012 Transactions, including 2012 Transaction Expenses;” 
  

	 	(zz)	Section 4.11(b)(13) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“payments on the Notes (and any exchange notes to be issued in exchange therefor) in accordance with this Indenture,
payments on the Senior Exchange Notes (and any exchange notes to be issued in exchange therefor) in accordance with the Senior Exchange Notes Indenture, payments on the 2020 Notes in accordance with the 2020 Notes Indenture and payments in respect
of Obligations under the Credit Agreement; provided that such Obligations were acquired by an Affiliate of the Issuer in compliance with this Indenture;” 
  

	 	(aaa)	Section 4.12(C) of the Indenture is hereby deleted in its entirety and replaced with the following: 

“Liens securing any Obligations in respect of other Indebtedness of the Issuer or a Guarantor incurred in compliance with
Section 4.09 hereof, in the case of this clause (C), so long as the Consolidated Secured Net Leverage Ratio of the Issuer and its Restricted Subsidiaries for the most recently ended four fiscal quarters for which internal financial statements
are available immediately preceding the date on which the Indebtedness secured by such Lien is incurred would have been no more than 3.50 to 1.00.” 
  

	 	(bbb)	Clauses (ii) and (iii) of Section 4.16 of the Indenture are hereby deleted in their entirety and replaced with the following: 

“(ii) performance of its obligations under and in connection with the Credit Facilities, this Indenture, the Notes (and
any exchange notes to be issued in exchange therefor), the Senior Exchange Notes Indenture, the Senior Exchange Notes (and any exchange notes to be issued in exchange therefor), the 2020 Notes Indenture, the 2020 Notes and the other agreements
contemplated hereby and thereby, (iii) actions incidental to the consummation of the Transactions or the 2012 Transactions,” 
  

	 	(ccc)	Section 4.18 of the Indenture is hereby deleted in its entirety and replaced with “[Reserved].”. 

  

	 	(ddd)	Section 6.01(a)(4) of the Indenture is hereby amended by replacing “$35,000,000” with “$100,000,000”. 

  

	 	(eee)	Section 6.01(a)(5) of the Indenture is hereby amended by replacing “$35,000,000” with “$100,000,000”. 

 Section 2. Amendments to the Notes. The Notes include certain of the foregoing provisions from the
Indenture to be deleted, amended or added pursuant to Section 1 hereof. Effective as of the Operative Time, such provisions from the Notes shall be deemed deleted, amended or added, as applicable. 

Section 3. Governing Law. THIS SUPPLEMENTAL INDENTURE WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 

Section 4. Successors. All agreements of the Issuer in this Supplemental Indenture shall bind its successors. All agreements of the Trustee in
this Supplemental Indenture shall bind its successors. All agreements of each Guarantor in this Supplemental Indenture shall bind its successors, except as otherwise provided in Section 11.06 of the Indenture. 

Section 5. Severability. In case any provision in this Supplemental Indenture shall be invalid, illegal or unenforceable, the validity, legality
and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
 Section 6. Counterpart Originals. The
parties may sign any number of copies of this Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. 

Section 7. Indenture Continues In Force and Effect. Except as specifically amended hereby, the Indenture shall continue in full force and effect,
and from and after the date hereof, the Indenture and this Supplemental Indenture shall constitute one instrument. 
 Section 8. Effect of
Headings. The Section headings herein are for convenience only, are not to be considered part of this Supplemental Indenture and shall in no way modify or restrict any of the terms or provisions hereof. 

Section 9. Trustee. The Trustee shall not be responsible for and makes no representation as to the validity or adequacy of this Supplemental
Indenture and it shall not be responsible for any the recitals contained herein. 
 Section 10. Waiver of Interest By Holders. Each Holder who
has validly tendered, or will validly tender, Notes for exchange in the Senior Notes Exchange Offer contemplated by the Offering Circular has agreed, or will agree upon such valid tender, to waive its right to receive payment of all interest that
has accrued from September 1, 2012 on such validly tendered Notes. 
 [Signature pages to follow.] 

 IN WITNESS WHEREOF, the Issuer, the Guarantors and the Trustee have caused this Supplemental
Indenture to be executed in their respective names as of the date first above written. 
  

			
	U.S. BANK NATIONAL ASSOCIATION
	as Trustee
		
	By:	 	 /s/ Donald T. Hurrelbrink

	Name:	 	Donald T. Hurrelbrink
	Title:	 	Vice President

  
 [Supplemental
Indenture Signature Pages] 

 
			
	IMS HEALTH INCORPORATED
	as Issuer
		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	Vice President and Treasurer
	
	 HEALTHCARE TECHNOLOGY INTERMEDIATE HOLDINGS, INC.

as Holdings

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	Vice President and Treasurer

  
 [Supplemental
Indenture Signature Pages] 

 
			
	ARSENAL HOLDING COMPANY
	ARSENAL HOLDING (II) COMPANY
	DATA NICHE ASSOCIATES, INC.
	IMS HEALTH FINANCE, INC.
	IMS HEALTH HOLDING CORPORATION
	IMS HEALTH INDIA HOLDING CORPORATION
	IMS HEALTH INVESTING CORPORATION
	IMS HEALTH INVESTMENTS, INC.
	IMS HEALTH PURCHASING, INC.
	IMS HEALTH TRADING CORPORATION
	IMS HOLDING INC.
	IMS SERVICES, LLC
	IMS TRADING MANAGEMENT, INC.
	RX INDIA CORPORATION
	TTC ACQUISITION CORPORATION
	 VALUEMEDICS RESEARCH, LLC
 as
Guarantors

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	President

  
 [Supplemental
Indenture Signature Pages] 

 
			
	IMS CONTRACTING & COMPLIANCE, INC.
	IMS GOVERNMENT SOLUTIONS, INC.
	IMS HEALTH TRANSPORTATION SERVICES CORPORATION
	IMS SOFTWARE SERVICES LTD.
	MED-VANTAGE, INC.
	 PHARMETRICS, INC.
 as
Guarantors

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	Treasurer

  
 [Supplemental
Indenture Signature Pages] 

 
			
	IMS HEALTH LICENSING ASSOCIATES, L.L.C.
	as Guarantor
		
	By:	 	 /s/ Maryanne Piorek

	Name:	 	Maryanne Piorek
	Title:	 	Responsible Officer

  
 [Supplemental
Indenture Signature Pages] 

 
			
	COORDINATED MANAGEMENT HOLDINGS, L.L.C.
	COORDINATED MANAGEMENT SYSTEMS, INC.
	MARKET RESEARCH MANAGEMENT, INC.
	 SPARTAN LEASING CORPORATION
 as
Guarantors

		
	By:	 	 /s/ Margaret F. Cupp

	Name:	 	Margaret F. Cupp
	Title:	 	President

  
 [Supplemental
Indenture Signature Pages] 

 
			
	IMS CHINAMETRIK INCORPORATED
	 as Guarantor

		
	By:	 	 /s/ Margaret F. Cupp

	Name:	 	Margaret F. Cupp
	Title:	 	Vice President

  
 [Supplemental
Indenture Signature Pages] 

 
			
	INTERCONTINENTAL MEDICAL STATISTICS INTERNATIONAL, LTD.
	 as Guarantor

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	Secretary

  
 [Supplemental
Indenture Signature Pages] 

 
			
	ENTERPRISE ASSOCIATES L.L.C.
	 as Guarantor

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	Vice President

  
 [Supplemental
Indenture Signature Pages] 

 
			
	THE TAR HEEL TRADING COMPANY, LLC
	 as Guarantor

		
	By:	 	 /s/ Jeffrey J. Ford

	Name:	 	Jeffrey J. Ford
	Title:	 	Vice President and Treasurer

  
 [Supplemental
Indenture Signature Pages]

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