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                                                                   EXHIBIT 10.20

                     AMENDED AND RESTATED CO-SALE AGREEMENT

         This AMENDED AND RESTATED CO-SALE AGREEMENT (this "Agreement") is made
as of this 10th day of November, 2000 by and among Digirad Corporation, a
Delaware corporation (formerly Aurora Technologies Corporation, a California
corporation) (the "Company"), each of the founders listed under the heading
"Founders" on SCHEDULE A attached hereto (each a "Founder", and collectively the
"Founders"), holders of a majority of the Series A Preferred Stock, Series B
Preferred Stock, Series C Preferred Stock, Series D Preferred Stock and Series E
Preferred Stock listed under the heading "Existing Investors" on SCHEDULE A
attached hereto (the "Existing Investors") and each of the purchasers of the
Series E Preferred Stock of the Company listed under the heading "New Investors"
on SCHEDULE A attached hereto (the "New Investors").

                                    RECITALS

         WHEREAS, the Founders and the Existing Investors have, from time to
time, purchased shares of the Company's Common Stock, Series A Preferred Stock,
Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock
and/or Series E Preferred Stock and have become parties to that certain Co-Sale
Agreement dated May 13, 1994, as amended by that certain Amendment No. 1 to the
Co-Sale Agreement dated December 8, 1995, that certain Amendment No. 2 to the
Co-Sale Agreement dated April 23, 1996, that certain Amendment No. 3 to the
Co-Sale Agreement dated September 6, 1996, that certain Amendment No. 4 to the
Co-Sale Agreement dated September 30, 1996, that certain Amendment No. 5 to the
Co-Sale Agreement dated August 8, 1997, that certain Amendment No. 6 to the
Co-Sale Agreement dated March 15, 2000 and that certain Addendum to Amendment
No. 6 to the Co-Sale Agreement dated April 6, 2000 (collectively, the "Co-Sale
Agreement").

         WHEREAS, the New Investors are purchasing shares of the Company's
Series E Preferred Stock pursuant to a Fourth Additional Series E Preferred
Stock Purchase Agreement dated as of even date herewith (the "Purchase
Agreement").

         WHEREAS, as an inducement to the New Investors to purchase shares of
the Series E Preferred Stock, the Company, the Founders, the Existing Investors
and the New Investors all desire to completely amend and restate the Co-Sale
Agreement pursuant to Section 7.2 with respect to the matters set forth therein.

         THEREFORE, in consideration of the mutual covenants set forth herein,
the parties agree as follows:

         1.       DEFINITIONS.

                  a.       "Stock" shall mean outstanding shares of the
Company's Common Stock now owned by the Founders.

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                  b.       "Preferred Stock" shall mean outstanding shares of
the Company's Series A Preferred Stock, Series B Preferred Stock, Series C
Preferred Stock, Series D Preferred Stock and Series E Preferred Stock.

                  c.       "Common Stock" shall mean the Company's Common Stock
and shares of Common Stock issued or issuable upon conversion of the Company's
outstanding Preferred Stock.

                  d.       "Stockholders" shall mean the Existing Investors and
the New Investors, collectively.

         2.       SALES BY FOUNDERS.

                  a.       If any Founder proposes to sell or transfer any
shares of Stock except as otherwise permitted herein, then such Founder shall
promptly give written notice (the "Notice") to the Company and the Stockholders
at least 20 days prior to the closing of such sale or transfer. The Notice shall
describe in reasonable detail the proposed sale or transfer including, without
limitation, the number of shares of Stock to be sold or transferred, the nature
of such sale or transfer, the consideration to be paid, and the name and address
of each prospective purchaser or transferee. In the event that the sale or
transfer is being made pursuant to the provisions of paragraph 3(a) or 3(b)
hereof, the Notice shall state under which paragraph the sale or transfer is
being made.

                  b.       Each Stockholder shall have the right, exercisable
upon written notice to such Founder within 15 days after receipt of the Notice,
to participate in such sale of Stock on the same terms and conditions. To the
extent one or more of the Stockholders exercise such right of participation in
accordance with the terms and conditions set forth below, the number of shares
of Stock that the Founder may sell in the transaction shall be correspondingly
reduced. A Stockholder with one or more affiliated funds may apportion the
number of shares it is entitled to sell pursuant to paragraph (c) below among
such funds in any manner the Stockholder may choose.

                  c.       Each Stockholder may sell all or any part of that
number of shares of Stock equal to the product obtained by multiplying (i) the
aggregate number of shares of Stock covered by the Notice by (ii) a fraction the
numerator of which is the number of shares of Common Stock owned by such
Stockholder at the time of the sale or transfer and the denominator of which is
the total number of shares of Common Stock owned by the Founder and all of the
Stockholders at the time of the sale or transfer. Notwithstanding the foregoing,
in the event of any purchase of shares of Stock by the Company (or its
assignees) pursuant to any right of first refusal or by the Stockholder under
paragraph (g) below, no Stockholder shall have any co-sale rights under this
Section 2 with respect to any shares of Stock so purchased.

                  d.       Each Stockholder electing to participate (each a
"Participant," and collectively, the "Participants") shall effect its
participation in the sale by promptly delivering to the Founder for transfer to
the prospective purchaser one or more certificates, properly endorsed for
transfer, which represent:

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                           (i)      the type and number of shares of Common
Stock which such Participant elects to sell; or

                           (ii)     that number of shares of Preferred Stock
which is at such time convertible into the number of shares of Common Stock
which such Participant elects to sell; provided, however, that if the
prospective purchaser objects to the delivery of shares of Preferred Stock in
lieu of Common Stock, such Participant shall convert such Preferred Stock into
shares of Common Stock and deliver such shares of Common Stock as provided in
subparagraph 2(d)(i) above. The Company agrees to make any such conversion
concurrent with the actual transfer of such shares to the purchaser.

                  e.       The stock certificate or certificates that the
Participant delivers to the Founder pursuant to paragraph 2(d) shall be
transferred to the prospective purchaser in consummation of the sale of the
Stock pursuant to the terms and conditions specified in the Notice, and the
Founder shall concurrently therewith remit to such Participant that portion of
the sale proceeds to which such Participant is entitled by reason of its
participation in such sale. To the extent that any prospective purchaser or
purchasers prohibits such assignment or otherwise refuses to purchase shares or
other securities from a Participant exercising its rights of co-sale hereunder,
the Founder shall not sell to such prospective purchaser or purchasers any Stock
unless and until, simultaneously with such sale, the Founder shall purchase such
shares or other securities from such Participant.

                  f.       The exercise or non-exercise of the rights of the
Stockholders hereunder to participate in one or more sales of Stock made by the
Founder shall not adversely affect their rights to participate in subsequent
sales of Stock subject to paragraph 2(a).

                  g.       Notwithstanding the foregoing, in the event the
holders of a majority of the outstanding shares of Preferred Stock held by the
Stockholders so elect, the Stockholders shall have the right, exercisable upon
written notice to the Founders within 15 days after receipt of the Notice, to
purchase, within 30 days of receipt of the Notice, all (but not less than all)
of the shares of Stock specified in the Notice, excluding any shares purchased
or designated for purchase by the Company (or its assignees) pursuant to any
Company right of first refusal; provided, however, in the event the Company (or
its assignees) has any right of first refusal with respect to such shares, the
time periods specified in this sentence shall extend from the later of the date
of receipt by the Stockholders of the Notice and the date of receipt by the
Stockholders of notice from the Company (or its assignee) as to its decision to
exercise its right of first refusal with respect to such shares. Each
Stockholder participating in such purchase shall purchase the number of shares
equal to the aggregate number of shares of Stock specified in the Notice,
excluding any shares purchased or designated for purchase by the Company (or its
assignees) pursuant to any Company right of first refusal, multiplied by a
fraction the numerator of which is the number of shares of Common Stock owned by
such Stockholder at the time of the sale or transfer and the denominator of
which is the total number of shares of Common Stock owned at such time by all
Stockholders participating in such purchase. Subject to the restrictions
contained herein, the closing for any such purchase shall be held on a date set
by the Company and a majority of the Stockholders participating in such
purchase. The Company shall give the participating Stockholders and each Founder
notice of the closing date, at which time the portion to be purchased by each
participating Stockholder shall be determined.

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         3.       EXEMPT TRANSFERS.

                  a.       Notwithstanding the foregoing, the co-sale rights of
the Stockholders shall not apply to (i) any pledge of Stock made pursuant to a
bona fide loan transaction that creates a mere security interest, (ii) any
transfer to the ancestors, descendants or spouse or to trusts for the benefit of
such persons or a Founder; or (iii) any bona fide gift; provided that (A) the
transferring Founder shall inform the Stockholders of such pledge, transfer or
gift prior to effecting it and (B) the pledgee, transferee or donee shall
furnish the Stockholders with a written agreement to be bound by and comply with
all provisions of Section 2. Such transferred Stock shall remain "Stock"
hereunder, and such pledgee, transferee or donee shall be treated as a "Founder"
for purposes of this Agreement.

                  b.       Notwithstanding the foregoing, the provisions of
Section 2 shall not apply to the sale of any Stock (i) to the public pursuant to
a registration statement filed with, and declared effective by, the Securities
and Exchange Commission under the Securities Act of 1933, as amended (the
"Securities Act") or (ii) to the Company, or (iii) if prior to such sale, the
Founder held less than 5% of the Company's outstanding shares.

         4.       PROHIBITED TRANSFERS.

                  a.       In the event a Founder should sell any Stock in
contravention of the co-sale rights of the Stockholders under this agreement (a
"Prohibited Transfer"), the Stockholders, in addition to such other remedies as
may be available at law, in equity or hereunder, shall have the put option
provided below, and the Founder shall be bound by the applicable provisions of
such option.

                  b.       In the event of a Prohibited Transfer, each
Stockholder shall have the right to sell to the Founder the type and number of
shares of Stock equal to the number of shares each Stockholder would have been
entitled to transfer to the purchaser had the Prohibited Transfer under Section
2(c) hereof been effected pursuant to and in compliance with the terms hereof.
Such sale shall be made on the following terms and conditions:

                           (i)      The price per share at which the shares are
to be sold to the Founder shall be equal to the price per share paid by the
purchaser to the Founder in the Prohibited Transfer. The Founder shall also
reimburse each Stockholder for any and all fees and expenses, including legal
fees and expenses incurred pursuant to the exercise or the attempted exercise of
the Stockholder's rights under Section 2.

                           (ii)     Within 90 days after the later of the dates
on which the Stockholder (A) received notice of the Prohibited Transfer or (B)
otherwise become aware of the Prohibited Transfer, each Stockholder shall, if
exercising the option created hereby, deliver to the Founder the certificate or
certificates representing shares to be sold, each certificate to be properly
endorsed for transfer.

                           (iii)    The Founder shall, upon receipt of the
certificate or certificates for the shares to be sold by a Stockholder, pursuant
to this subparagraph 4(b), pay the aggregate purchase price therefor and the
amount of reimbursable fees and expenses, as specified in subparagraph 4(b)(i),
in cash or by other means acceptable to the Stockholder.

                                       4
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                           (iv)     Notwithstanding the foregoing, any attempt
by a Founder to transfer Stock in violation of Section 2 hereof shall be void
and the Company agrees it will not effect such a transfer nor will it treat any
alleged transferee as the holder of such shares without the written consent of a
majority in interest of the Stockholders.

         5.       ASSIGNMENT OF COMPANY'S RIGHT OF FIRST REFUSAL. In the event
the Company does not exercise its right of first refusal provided for in any
stockholder agreement entered into between the Company and a Founder, the
Company shall assign such right to the Stockholders. In the event the holders of
a majority of the outstanding shares of Preferred Stock so elect, the
Stockholders may exercise such right, within the time period specified in such
Stockholder Agreement, to purchase all (but not less than all) of the shares
subject to the Company's right of first refusal and specified in the notice to
the Company by the Founder as provided for in such Stockholder Agreement (the
"Offered Shares"). In that event, each Stockholder shall purchase the number of
shares of Stock specified in the notice to the Company equal to the number of
Offered Shares multiplied by the fraction set forth in Section 2(g) hereof.

         6.       LEGEND.

                  a.       Each certificate representing shares of Stock now or
hereafter owned by the Founders or issued to any person in connection with a
transfer pursuant to Section 3(a) hereof shall be endorsed with the following
legend:

         "THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES
         REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS
         OF A CERTAIN AMENDED AND RESTATED CO-SALE AGREEMENT BY AND BETWEEN THE
         STOCKHOLDER, THE CORPORATION AND CERTAIN HOLDERS OF STOCK OF THE
         CORPORATION AS AMENDED FROM TIME TO TIME. COPIES OF SUCH AGREEMENT MAY
         BE OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY OF THE CORPORATION."

                  b.       Each Founder agrees that the Company may instruct its
transfer agent to impose transfer restrictions on the shares represented by
certificates bearing the legend referred to in Section 6(a) above to enforce the
provisions of this Agreement and the Company agrees to promptly do so. The
legend shall be removed upon termination of this Agreement.

         7.       MISCELLANEOUS.

                  7.1      GOVERNING LAW. This Agreement shall be governed by
and construed under the laws of the State of California, without regard to
principles of conflicts of laws.

                  7.2      AMENDMENT. Any provision may be amended and the
observance thereof may be waived (either generally or in a particular instance
and either retroactively or prospectively), only by the written consent of (i)
as to the Company, the Company, (ii) as to the Stockholders, by persons holding
more than fifty percent (50%) in interest of the Common Stock held by the
Stockholders and their assignees, pursuant to Section 7.3 hereof, and (iii) as
to each Founder, such Founder, provided that any Stockholder may waive any of
its rights hereunder without obtaining the consent of any other Stockholder. Any
amendment or waiver effected in

                                       5
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accordance with clauses (i), (ii) and (iii) of this paragraph shall be binding
upon the Company, each Stockholder, its successors and assigns, and each
Founder.

                  7.3      ASSIGNMENT OF RIGHTS. This Agreement and the rights
and obligations of the parties hereunder shall inure to benefit of, and be
binding upon, their respective successors, assigns and legal representatives.
The rights of the Stockholders hereunder are only assignable (i) by each of such
Stockholders to any other Stockholder, (ii) to an assignee or transferee who
acquires all of the Common Stock purchased by a Stockholder or at least 50,000
shares of Common Stock or (iii) to an affiliated entity controlling, controlled
by, or under common control with, a Stockholder.

                  7.4      TERM. This Agreement shall terminate upon the earlier
of (i) the closing of a firm commitment underwritten public offering pursuant to
an effective registration statement under the Securities Act of 1933, as
amended, covering the offer and sale of the Company's Common Stock at an
aggregate offering price of not less than $15,000,000 and at a public offering
price of not less than $7.50 per share (as adjusted to reflect subsequent stock
dividends, stock splits or recapitalizations) and (ii) the closing of the
Company's sale of all or substantially all of its assets or the acquisition of
the Company by another entity by means of merger or consolidation resulting in
the exchange of the outstanding shares of the Company's capital stock for
securities or consideration issued, or caused to be issued, by the acquiring
entity or its subsidiary.

                  7.5      OWNERSHIP. Each Founder represents and warrants that
he is the sole legal and beneficial owner of the shares of stock subject to this
Agreement and that no other person has any interest (other than a community
property interest) in such shares.

                  7.6      NOTICES. All notices required or permitted hereunder
shall be in writing and shall be deemed effectively given upon personal delivery
to the party to be notified or five days after deposit in the United States
mail, by registered or certified mail, postage prepaid and properly addressed to
the party to be notified as set forth on the signature page hereof or at such
other address as such party may designate by ten (10) days' advance written
notice to the other parties hereto.

                  7.7      SEVERABILITY. In the event one or more of the
provisions of this Agreement should, for any reason, be held to be invalid,
illegal or unenforceable in any respect, such invalidity, illegality or
unenforceability shall not affect any other provisions of this Agreement, and
this Agreement shall be construed as if such invalid, illegal or unenforceable
provision had never been contained herein.

                  7.8      ATTORNEYS' FEES. In the event that any dispute among
the parties to this Agreement should result in litigation, the prevailing party
in such dispute shall be entitled to recover from the losing party all fees,
costs and expenses of enforcing any right of such prevailing party under or with
respect to this Agreement, including without limitation, such reasonable fees
and expenses of attorneys and accountants, which shall include, without
limitation, all fees, costs and expenses of appeals.

                                       6
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                  7.9      COUNTERPARTS. This Agreement may be executed in two
or more counterparts, each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument. The parties
contemplate that Additional Closings may occur under the Purchase Agreement by
which additional shares of Series E Preferred Stock will be sold to certain
investors. Such new investors shall become party to this Agreement by executing
counterpart signature pages and no further signature shall be required by the
Company, the Founders, the Existing Investors or the New Investors. Such
investors shall be deemed to be "New Investors" and "Stockholders" under this
Agreement for all purposes hereunder.

                                       7
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         IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

COMPANY:                               DIGIRAD CORPORATION,
                                       a Delaware corporation

                                       By:     /s/ Scott Huennekens
                                          --------------------------------------
                                          Scott Huennekens, President

FOUNDERS:                              JACK F. BUTLER

                                       By:     /s/ Jack F. Butler
                                          --------------------------------------
                                          Jack F. Butler

                            Address:   16650 Las Cuestas
                                       Rancho Santa Fe, CA  92067

                                       CLINTON L. LINGREN

                                       By:     /s/ Clinton L. Lingren
                                          --------------------------------------
                                          Clinton L. Lingren

                            Address:   6211 Hannon Ct.
                                       San Diego, CA  92117

                                       GERALD G. LOEHR SEPARATE PROPERTY
                                       TRUST U.S. TRUST COMPANY, N.A.,
                                       CO-TRUSTEE

                                       By:     /s/ STEVE VOLK            11/8/00
                                          --------------------------------------
                                               Steve Volk, CTFA
                                       Its:    VICE PRESIDENT &
                                               SENIOR TRUST OFFICER
                                           -------------------------------------

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
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                                       GERALD G. AND LINDA J. LOEHR FAMILY
                                       TRUST

                                       By:     /s/ Linda Loehr
                                          --------------------------------------
                                          Trustee

                                       By:
                                          --------------------------------------
                                          Trustee

                           Address:    P.O. Box 675207
                                       Rancho Santa Fe, CA  92067

EXISTING INVESTORS:                    KINGSBURY CAPITAL PARTNERS, L.P., III
                                       KINGSBURY CAPITAL PARTNERS, L.P.
                                       KINGSBURY CAPITAL PARTNERS, L.P. II

                                       By: Kingsbury Associates, L.P.,
                                           Its General Counsel

                                       By:     /s/ Timothy J. Wollaeger
                                          --------------------------------------
                                          Timothy J. Wollaeger,
                                          General Partner

                           Address:    3655 Nobel Drive, Suite 490
                                       San Diego, CA  92122

                                       SORRENTO GROWTH PARTNERS I, L.P.

                                       By: Sorrento Equity Growth
                                           Partners I, L.P.,
                                           Its General Partner

                                       By: Sorrento Associates, Inc.,
                                           Its General Partner

                                       By:     /s/ Robert M. Jaffe
                                          --------------------------------------
                                          Robert M. Jaffee, President

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
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                                       SORRENTO VENTURES II, L.P.

                                       By: Sorrento Equity Partners, L.P.,
                                           Its General Partner

                                       By: Sorrento Associates, Inc.,
                                           Its General Partner

                                       By:     /s/ Robert M. Jaffee
                                          --------------------------------------
                                          Robert M. Jaffee, President

                                       SORRENTO VENTURES III, L.P.

                                       By: Sorrento Equity Partners, III, L.P.,
                                           Its General Partner

                                       By: Sorrento Associates, Inc.,
                                           Its General Partner

                                       By:     /s/ Robert M. Jaffee
                                          --------------------------------------
                                          Robert M. Jaffee, President

                                       SORRENTO VENTURES CE, L.P.

                                       By: Sorrento Equity Partners, III, L.P.,
                                           Its General Partner

                                       By: Sorrento Associates, Inc.,
                                           Its General Partner

                                       By:     /s/ Robert M. Jaffee
                                          --------------------------------------
                                          Robert M. Jaffee, President

                           Address:    4370 La Jolla Village Drive, Suite 1040
                                       San Diego, CA  92122

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
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                                       VECTOR LATER-STAGE EQUITY FUND, L.P.

                                       By: Vector Fund Management, II, L.L.C.
                                           Its General Partner

                                       By:     /s/ Douglas Reed
                                          --------------------------------------
                                          Douglas Reed, M.D.
                                          Managing Director

                                       VECTOR LATER-STAGE EQUITY FUND II, L.P.

                                       By: Vector Fund Management, II, L.L.C.
                                           Its General Partner

                                       By:     /s/ Douglas Reed
                                          --------------------------------------
                                          Douglas Reed, M.D.
                                          Managing Director

                                       VECTOR LATER-STAGE EQUITY FUND II
                                       (Q.P.), L.P.

                                       By: Vector Fund Management, II, L.L.C.
                                           Its General Partner

                                       By:     /s/ Douglas Reed
                                          --------------------------------------
                                          Douglas Reed, M.D.
                                          Managing Director

                           Address:    1751 Lake Cook Road, Suite 350
                                       Deerfield, IL  60015

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
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                                       HEALTH CARE INDEMNITY, INC.

                                       By:  Columbia/HCA Healthcare Corporation
                                       Its: Investment Advisor

                                       By:     /s/ James T. Glasscock
                                          --------------------------------------

                                       Name:   James T. Glasscock
                                            ------------------------------------

                                       Its:    VP, Investment
                                           -------------------------------------

                           Address:    One Park Plaza
                                       Post Office Box 550
                                       Nashville, TN  37202-0550

                                       OCEAN AVENUE INVESTORS, LLC -
                                       ANACAPA FUND

                                       By:     /s/ Michael Browne
                                          --------------------------------------
                                          Michael Browne
                                          Manager

                                       OCEAN AVENUE INVESTORS, LLC -
                                       FOUNDERS FUND

                                       By:     /s/ Michael Browne
                                          --------------------------------------
                                          Michael Browne
                                          Manager

                                       OCEAN AVENUE INVESTORS, LLC -
                                       REDSTONE FUND

                                       By:     /s/ Michael Browne
                                          --------------------------------------
                                          Michael Browne
                                          Manager

                           Address:    100 Wilshire Boulevard, Suite 1850
                                       Santa Monica, CA  90401

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

NEW INVESTORS:                         KINGSBURY CAPITAL PARTNERS, L.P., III

                                       By: Kingsbury Associates, L.P.,
                                           Its General Counsel

                                       By:     /s/ Timothy J. Wollaeger
                                          --------------------------------------
                                          Timothy J. Wollaeger,
                                          General Partner

                           Address:    3655 Nobel Drive, Suite 490
                                       San Diego, CA  92122

                                       KINGSBURY CAPITAL PARTNERS, L.P., IV

                                       By: Kingsbury Associates, L.P.,
                                           Its General Counsel

                                       By:     /s/ Timothy J. Wollaeger
                                          --------------------------------------
                                          Timothy J. Wollaeger,
                                          General Partner

                           Address:    3655 Nobel Drive, Suite 490
                                       San Diego, CA  92122

                                       VECTOR LATER-STAGE EQUITY FUND II
                                       (QP), L.P.

                                       By: Vector Fund Management II, L.L.C.
                                           Its General Partner

                                       By:     /s/ Douglas Reed
                                          --------------------------------------
                                          Douglas Reed, M.D.
                                          Managing Director

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

                                       VECTOR LATER-STAGE EQUITY FUND II, L.P.

                                       By: Vector Fund Management, II, L.L.C.
                                           Its General Partner

                                       By:     /s/ Douglas Reed
                                          --------------------------------------
                                          Douglas Reed, M.D.
                                          Managing Director

                           Address:    1751 Lake Cook Road, Suite 350
                                       Deerfield, IL  60015

                                       OCEAN AVENUE INVESTORS, LLC -
                                       ANACAPA FUND I

                                       By:     /s/ Michael Browne
                                          --------------------------------------
                                          Michael Browne
                                          Manager

                            Address:   100 Wilshire Boulevard, Suite 1850
                                       Santa Monica, CA  90401

                                       HEALTH CARE INDEMNITY, INC.

                                       By:  Columbia/HCA Healthcare Corporation
                                       Its: Investment Advisor

                                       By:     /s/ James Glasscock
                                          --------------------------------------

                                       Name:   James T. Glasscock
                                            ------------------------------------

                                       Its:    VP, Investments
                                           -------------------------------------

                           Address:    One Park Plaza
                                       Post Office Box 550
                                       Nashville, TN  37202-0550

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

                                       AUREUS DIGIRAD, LLC

                                       By:     /s/ Robert M. Averick
                                          --------------------------------------

                                       Name:   Robert M. Averick
                                            ------------------------------------

                                       Its:    Member
                                           -------------------------------------

                           Address:    100 First Stamford Place
                                       Stamford, CT  06902

                                       MERRILL LYNCH VENTURES, LLC

                                       By:     /s/ Edward J. Higgins
                                          --------------------------------------
                                          Edward J. Higgins
                                          Vice President

                           Address:    2 World Financial Center, 23rd Floor
                                       New York, NY 10281
                                       Attn:  Robert F. Tully

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

                                       MID CAROLINA CARDIOLOGY, PA

                                       By:     /s/ Stephen A. McAdams MD
                                          --------------------------------------

                                       Its:    Chief Executive Officer
                                           -------------------------------------

                                       Name:   Stephen A. McAdams
                                            ------------------------------------

                           Address:    1718 East 4th Street, Suite 901
                                       Charlotte, NC  28277
                                       Attn: Stephen A. McAdams

                                       STEPHEN ALAN MCADAMS AND LOU ANN
                                       MCADAMS, AS JOINT TENANTS

                                       By:     /s/ Stephen Alan McAdams
                                          --------------------------------------
                                          Stephen Alan McAdams

                                       By:     /s/ Lou A. McAdams
                                          --------------------------------------
                                          Lou Ann McAdams

                           Address:    4901 Old Course Drive
                                       Charlotte, NC  28277

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

                                       AKINYELE ALUKO, M.D.

                                               /s/ Akinyele Aluko
                                       -----------------------------------------
                                       Akinyele Aluko, M.D.

                           Address:    5725 Laurium Road
                                       Charlotte, NC  28226

                                       HARVEY FAMILY LLC

                                       By:     /s/ John Harvey
                                          --------------------------------------
                                          John Harvey
                                          Manager

                           Address:    2305 NW Grand Boulevard
                                       Oklahoma City, OK  73116

                                       GFP DIGIRAD, LLC

                                       By:     /s/ ILLEGIBLE
                                          --------------------------------------

                                       Its:    Managing Member
                                           -------------------------------------

                                       Name:   ILLEGIBLE
                                            ------------------------------------

                           Address:    4000 West Brown Deer Road
                                       Milwaukee, WI  53209-1221

                                       DR. JEROME WILLIAMS, JR.

                                       By:     /s/ Jerome Williams, Jr.
                                          --------------------------------------

                                       Its:
                                           -------------------------------------

                                       Name:
                                            ------------------------------------

                           Address:    4543 Rosecliff Drive
                                       Charlotte, NC  28277

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

                                       DWAYNE A. SCHMIDT

                                               /s/ Dwayne Schmidt
                                       -----------------------------------------
                                       Dwayne A. Schmidt

                           Address:    327 Northwest 14th Street
                                       Oklahoma City, OK  73103

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

                                       FISK VENTURES LLC

                                       By:     /s/ ILLEGIBLE
                                          --------------------------------------

                                       Its:    Manager
                                           -------------------------------------

                           Address:    4041 North Main Street
                                       Post Office Box 1919
                                       Racine, Wisconsin 53401-1919

                                       INGLEWOOD VENTURES, LP

                                       By:     /s/ Daniel C. Wood
                                          --------------------------------------

                                       Its:    Member
                                           -------------------------------------

                           Address:    12526 High Bluff Drive, Suite 300
                                       San Diego, CA  92130

                                       THE UNIVERSITY OF NORTH CAROLINA AT
                                       CHAPEL HILL FOUNDATION INVESTMENT
                                       FUND, INC.

                                       By:     /s/ Mark W. Yusko
                                          --------------------------------------
                                          Mark W. Yusko

                                       Its:    Assistant Treasurer
                                           -------------------------------------

                           Address:    308 West Rosemary Street, Suite 203
                                       Chapel Hill, NC  27516

                                       PALIVACINNI PARTNERS, LLC

                                       By:     /s/ Peter K. Shagory
                                          --------------------------------------
                                          Peter K. Shagory

                                       Its:    Manager
                                           -------------------------------------

                           Address:    1751 Lake Cook Road, Suite 350
                                       Deerfield, IL  60015

                         [SIGNATURE PAGE TO AMENDED AND
                           RESTATED CO-SALE AGREEMENT]
<Page>

                                CONSENT OF SPOUSE
                    (FOR SHARES OF STOCK HELD BY INDIVIDUALS)

         I acknowledge that I have read the foregoing Amended and Restated
Co-Sale Agreement and that I know its contents. I am aware that by its
provisions if I and/or my spouse agree to sell all or part of the shares of the
Company held of record by either or both of us, including my community interest
in such shares, if any, co-sale rights (as described in the Amended and Restated
Co-Sale Agreement) must be granted to the Stockholders by the seller. I hereby
agree that those shares and my interest in them, if any, are subject to the
provisions of the Amended and Restated Co-Sale Agreement and that I will take no
action at any time to hinder operation of, or violate, the Amended and Restated
Co-Sale Agreement.

                                             /s/ Sharon Lingren
                                          --------------------------------------
                                          (Signature of Spouse)

<Page>

                                CONSENT OF SPOUSE
                    (FOR SHARES OF STOCK HELD BY INDIVIDUALS)

         I acknowledge that I have read the foregoing Amended and Restated
Co-Sale Agreement and that I know its contents. I am aware that by its
provisions if I and/or my spouse agree to sell all or part of the shares of the
Company held of record by either or both of us, including my community interest
in such shares, if any, co-sale rights (as described in the Amended and Restated
Co-Sale Agreement) must be granted to the Stockholders by the seller. I hereby
agree that those shares and my interest in them, if any, are subject to the
provisions of the Amended and Restated Co-Sale Agreement and that I will take no
action at any time to hinder operation of, or violate, the Amended and Restated
Co-Sale Agreement.

                                             /s/ Lou A. McAdams
                                          --------------------------------------
                                          (Signature of Spouse)

<Page>

                                CONSENT OF SPOUSE
                    (FOR SHARES OF STOCK HELD BY INDIVIDUALS)

         I acknowledge that I have read the foregoing Amended and Restated
Co-Sale Agreement and that I know its contents. I am aware that by its
provisions if I and/or my spouse agree to sell all or part of the shares of the
Company held of record by either or both of us, including my community interest
in such shares, if any, co-sale rights (as described in the Amended and Restated
Co-Sale Agreement) must be granted to the Stockholders by the seller. I hereby
agree that those shares and my interest in them, if any, are subject to the
provisions of the Amended and Restated Co-Sale Agreement and that I will take no
action at any time to hinder operation of, or violate, the Amended and Restated
Co-Sale Agreement.

                                             /s/ ILLEGIBLE
                                          --------------------------------------
                                          (Signature of Spouse)

<Page>

                                CONSENT OF SPOUSE
                    (FOR SHARES OF STOCK HELD BY INDIVIDUALS)

         I acknowledge that I have read the foregoing Amended and Restated
Co-Sale Agreement and that I know its contents. I am aware that by its
provisions if I and/or my spouse agree to sell all or part of the shares of the
Company held of record by either or both of us, including my community interest
in such shares, if any, co-sale rights (as described in the Amended and Restated
Co-Sale Agreement) must be granted to the Stockholders by the seller. I hereby
agree that those shares and my interest in them, if any, are subject to the
provisions of the Amended and Restated Co-Sale Agreement and that I will take no
action at any time to hinder operation of, or violate, the Amended and Restated
Co-Sale Agreement.

                                             /s/ ILLEGIBLE
                                          --------------------------------------
                                          (Signature of Spouse)

<Page>

                                CONSENT OF SPOUSE
                    (FOR SHARES OF STOCK HELD BY INDIVIDUALS)

         I acknowledge that I have read the foregoing Amended and Restated
Co-Sale Agreement and that I know its contents. I am aware that by its
provisions if I and/or my spouse agree to sell all or part of the shares of the
Company held of record by either or both of us, including my community interest
in such shares, if any, co-sale rights (as described in the Amended and Restated
Co-Sale Agreement) must be granted to the Stockholders by the seller. I hereby
agree that those shares and my interest in them, if any, are subject to the
provisions of the Amended and Restated Co-Sale Agreement and that I will take no
action at any time to hinder operation of, or violate, the Amended and Restated
Co-Sale Agreement.

                                             /s/ ILLEGIBLE
                                          --------------------------------------
                                          (Signature of Spouse)

<Page>

                                CONSENT OF SPOUSE
                    (FOR SHARES OF STOCK HELD BY INDIVIDUALS)

         I acknowledge that I have read the foregoing Amended and Restated
Co-Sale Agreement and that I know its contents. I am aware that by its
provisions if I and/or my spouse agree to sell all or part of the shares of the
Company held of record by either or both of us, including my community interest
in such shares, if any, co-sale rights (as described in the Amended and Restated
Co-Sale Agreement) must be granted to the Stockholders by the seller. I hereby
agree that those shares and my interest in them, if any, are subject to the
provisions of the Amended and Restated Co-Sale Agreement and that I will take no
action at any time to hinder operation of, or violate, the Amended and Restated
Co-Sale Agreement.

                                             /s/ ILLEGIBLE
                                          --------------------------------------
                                          (Signature of Spouse)

<Page>

                                   SCHEDULE A

FOUNDERS

Jack F. Butler, Sr.
Clinton L. Lingren
Gerald G. Loehr Trust
Gerald G. and Linda J. Loehr Family Trust

EXISTING INVESTORS

Vector Later-Stage Equity Fund, L.P.
Vector Later-Stage Equity Fund II, L.P.
Vector Later-Stage Equity Fund II (Q.P.), L.P.
Furman Selz SBIC L.P.
Sorrento Growth Partners I, L.P.
Sorrento Ventures II, L.P.
Sorrento Ventures III, L.P.
Sorrento Ventures CE, L.P.
Kingsbury Capital Partners, L.P.
Kingsbury Capital Partners, L.P., II
Kingsbury Capital Partners, L.P., III
Jack F. Butler, Sr.
Gerald G. Loehr Trust
William L. Ashburn
Karen A. Klause
Kenneth E. Olson Trust
Peter T. Dunn
Dunn Family Trust
Nathan P. Dunn
Kyla E. Dunn
The Arthur & Sophie Brody Revocable Trust DTD 04/13/89
Malin Burnham
Philip L. Elkus Trust DTD 09/09/74
Elliot Feuerstein Trust DTD 05/14/82
Stanley and Maxine Firestone Trust DTD 12/02/88
Ira R. and Joan P. Katz Qualified Marital Trust
Knowles Family Trust
The SDL Trust
Arthur E. Nicholas
The Stanley E. and Pauline M. Foster Trust DTD  07/31/81
Page Trust DTD 03/03/89
Forrest N. Shumway & Patricia K. Shumway Trust DTD 04/26/94
Derbes Family Trust U/D/T 04/25/86

                                      A-1
<Page>

EXISTING INVESTORS (CONTINUED)

Sutro Investment Partners V., LLC
SBSF Biotechnology Fund, L.P.
SBSF Biotechnology Partners Fund, L.P.
ABS Employees' Venture Fund Limited Partnership
JAFCO Co., Ltd.
JAFCO R-3 Investment Enterprise Partnership
JAFCO JS3 Investment Enterprise Partnership
JAFCO G-6 (A) Investment Enterprise Partnership
JAFCO G-6 (B) Investment Enterprise Partnership
JAFCO G-7 (A) Investment Enterprise Partnership
JAFCO G-7 (B) Investment Enterprise Partnership
Johnson & Johnson Development Corporation
Health Care Indemnity, Inc.
Mitsui & Co., Ltd.
MVC Global Japan Fund I
Ocean Avenue Investors, LLC - Founders Fund
Ocean Avenue Investors, LLC - Redstone Fund
Ocean Avenue Investors, LLC - Anacapa Fund I

NEW INVESTORS

Kingsbury Capital Partners L.P., III
Kingsbury Capital Partners L.P., IV
Vector Later-Stage Equity Fund II, L.P.
Vector Later-Stage Equity Fund II (Q.P.), L.P.
Health Care Indemnity, Inc.
Ocean Avenue Investors, LLC - Acacapa Fund
Aureus Digirad, LLC
Merrill Lynch Ventures, LLC
Mid Carolina Cardiology, PA
Stephen Alan McAdams and Lou Ann McAdams, As Joint Tenants
Akinyele Aluko, M.D.
Harvey Family LLC
GFP Digirad
Dr. Jerome Williams, Jr.
Dwayne A. Schmidt
Richard N. Linder and Judy F. Linder
Fisk Ventures LLC
IngleWood Ventures, LP
The University of North Carolina at Chapel Hill
         Foundation Investment Fund, Inc.
Palivacinni Partners, LLC

                                      A-2<Page>

                                                                   EXHIBIT 10.21

                              AMENDED AND RESTATED
                            SERIES E VOTING AGREEMENT

         This AMENDED AND RESTATED SERIES E VOTING AGREEMENT (this "Agreement")
is made as of this 10th day of November 2000 by and among Digirad Corporation, a
Delaware corporation (the "Company"), holders of a majority of the Series E
Preferred Stock of the Company identified on SCHEDULE A attached hereto under
the heading "Existing Investors" (the "Existing Investors") and each of the
purchasers of the Series E Preferred Stock of the Company identified on SCHEDULE
A attached hereto under the heading "New Investors" (the "New Investors"). The
Existing Investors and the New Investors are collectively referred to herein as,
individually, an "Investor" and, collectively, the "Investors."

                                    RECITALS

         A. The Company has previously sold and issued shares of its Series E
Preferred Stock to the Existing Investors, pursuant to which the Existing
Investors have become parties to that certain Series E Voting Agreement dated
June 23, 1998, as amended by that certain Amendment Number One to the Series E
Voting Agreement dated March 15, 2000 and that certain Addendum to Amendment
Number One to the Series E Voting Agreement dated April 6, 2000 (collectively,
the "Voting Agreement");

         B. The Company desires to sell and issue shares of its Series E
Preferred Stock pursuant to that certain Fourth Additional Series E Preferred
Stock Purchase Agreement of even date herewith (the "Purchase Agreement"); and

         C. As an inducement to the New Investors to purchase shares of its
Series E Preferred Stock, the Company and the Existing Investors all desire to
completely amend and restate the Voting Agreement pursuant to Section 2(d) with
respect to the matters set forth therein.

         NOW, THEREFORE, in consideration of the foregoing and of the mutual
promises and covenants contained herein it is hereby agreed:

         1.       VOTING OF SHARES.

                  (a) Only with respect to a proposal submitted for stockholder
vote for matters on which the Series E Preferred Stock has a separate series
voting right as provided by applicable law (a "Stockholder Proposal"), each
Investor agrees to vote its shares of Series E Preferred Stock in connection
with such separate series voting right for or against such Stockholder Proposal
in the same proportion as a majority of the then outstanding shares of all
series of Preferred Stock (voting as a single class) are voted or abstain.

                  (b) Notwithstanding subsection (a) above, (i) with respect to
any proposal submitted for stockholder vote that meets the criteria set forth in
Article IV, Section B(8)(d) of the Amended and Restated Certificate of
Incorporation, the Investor will not be subject to the restrictions of
subsection(a) above.

<Page>

         2. SUCCESSORS AND ASSIGNS. This Agreement shall bind each Investor and
each and all of the heirs, executors, administrators, personal representatives,
successors, and assigns thereof, and shall inure to the benefit of the Investor,
and its permitted transferees.

         3. COUNTERPARTS. This Agreement may be executed in multiple
counterparts, each of which shall be deemed an original but all of which taken
together shall constitute one instrument. The parties contemplate that
Additional Closings may occur under the Purchase Agreement by which additional
shares of Series E Preferred Stock will be sold to certain investors. Such new
investors shall become party to this Agreement by executing counterpart
signature pages and no further signature shall be required by the Company, the
Existing Investors or the New Investors. Such investors shall be deemed to be
"New Investors" and "Investors" under this Agreement for all purposes hereunder.

         4. SEVERABILITY. If in any judicial proceedings, a court shall refuse
to enforce any of the provisions of this Agreement, then such unenforceable
provision shall be deemed modified or limited so as to effectuate, to the
maximum extent possible, the parties' expressed intent, and if no such
modification or limitation could render it enforceable it shall be eliminated
from this Agreement, and the balance of this Agreement shall be interpreted as
if such provision were so eliminated and shall be enforceable in accordance with
its terms.

         5. ENTIRE AGREEMENT. This Agreement constitutes the full and entire
understanding and agreement between the parties with regard to the subjects
hereof and thereof, and supercedes all prior agreements with regard to such
subjects.

         6. AMENDMENTS. This Agreement may not be amended, modified or
terminated, except with the written consent of the Company and Investors holding
a majority in interest of the Series E Preferred Stock.

         7. GOVERNING LAW. This Agreement shall be governed by the internal laws
of the State of Delaware without regard to principles of conflict of laws.

         8. REMEDIES. Each of the parties hereby acknowledges and agrees that
the legal remedies available, in the event the covenants and agreements made in
this Agreement are violated, would be inadequate and that any party shall be
entitled, without posting any bond or other security, to temporary, preliminary
and permanent injunctive relief, specific performance and other equitable
remedies in the event of such a violation, in addition to any other remedies
which such party may have at law or in equity.

         9. ATTORNEYS' FEES. In any legal proceeding arising out of this
Agreement, including with respect to any instrument, document or agreement made
under or in connection with this Agreement, the prevailing party shall be
entitled to recover its costs and actual attorneys' fees. As used in this
Agreement, "actual attorneys' fees" shall mean the full and actual cost of any
legal services actually performed in connection with the matters involved,
calculated on the basis of the usual hourly fees charged by the attorneys
performing such services.

                                       2

<Page>

         IN WITNESS WHEREOF, the undersigned have caused this agreement to be
signed as of the date first set forth above.

COMPANY:                            DIGIRAD CORPORATION:

                                    By: /s/ Scott Huennekens
                                        ------------------------------
                                        Scott Huennekens, President

                          Address:  9350 Trade Place
                                    San Diego, CA 92126-6334

EXISTING INVESTORS:                 KINGSBURY CAPITAL PARTNERS, L.P., III
                                    KINGSBURY CAPITAL PARTNERS, L.P.
                                    KINGSBURY CAPTIAL PARTNERS, L.P. II

                                    By: Kingsbury Associates, L.P.,
                                        Its General Counsel

                                    By: /s/ Timothy J. Wollaeger
                                        ------------------------------
                                        Timothy J. Wollaeger,
                                        General Partner

                          Address:  3655 Nobel Drive, Suite 490
                                    San Diego, CA  92122

                                    SORRENTO GROWTH PARTNERS I, L.P.

                                    By: Sorrento Equity Growth Partners I, L.P.,
                                        Its General Partner

                                    By: Sorrento Associates, Inc.,
                                        Its General Partner

                                    By: /s/ Robert M. Jaffee
                                        ------------------------------
                                        Robert M. Jaffee, President

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                    SORRENTO VENTURES II, L.P.

                                    By: Sorrento Equity Partners, L.P.,
                                        Its General Partner

                                    By: Sorrento Associates, Inc.,
                                        Its General Partner

                                    By: /s/ Robert M. Jaffee
                                        ------------------------------
                                        Robert M. Jaffee, President

                                    SORRENTO VENTURES III, L.P.

                                    By: Sorrento Equity Partners, III, L.P.,
                                        Its General Partner

                                    By: Sorrento Associates, Inc.,
                                        Its General Partner

                                    By: /s/ Robert M. Jaffee
                                        ------------------------------
                                        Robert M. Jaffee, President

                                    SORRENTO VENTURES CE, L.P.

                                    By: Sorrento Equity Partners, III, L.P.,
                                        Its General Partner

                                    By: Sorrento Associates, Inc.,
                                        Its General Partner

                                    By: /s/ Robert M. Jaffe
                                        ------------------------------
                                        Robert M. Jaffee, President

                          Address:  4370 La Jolla Village Drive, Suite 1040
                                    San Diego, CA  92122

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                    VECTOR LATER-STAGE EQUITY FUND, L.P.

                                    By: Vector Fund Management, II, L.L.C.
                                        Its General Partner

                                    By: /s/ Douglas Reed
                                        ------------------------------
                                        Douglas Reed, M.D.
                                        Managing Director

                                    VECTOR LATER-STAGE EQUITY FUND II, L.P.

                                    By: Vector Fund Management, II, L.L.C.
                                        Its General Partner

                                    By: /s/ Douglas Reed
                                        Douglas Reed, M.D.
                                        ------------------------------
                                        Managing Director

                                    VECTOR LATER-STAGE EQUITY FUND II
                                    (Q.P.), L.P.

                                    By: Vector Fund Management, II, L.L.C.
                                        Its General Partner

                                    By: /s/ Douglas Reed
                                        K. Flynn McDonald
                                        ------------------------------
                                        Managing Director

                          Address:  1751 Lake Cook Road, Suite 350
                                    Deerfield, IL  60015

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                    HEALTH CARE INDEMNITY, INC.

                                    By:      Columbia/HCA Healthcare Corporation
                                    Its:     Investment Advisor

                                    By:      /s/ James T. Glasscock
                                             -----------------------------------

                                    Name:    James T. Glasscock
                                             -----------------------------------

                                    Its:     VP, Investments
                                             -----------------------------------

                          Address:  One Park Plaza
                                    Post Office Box 550
                                    Nashville, TN 37202-0550

                                    OCEAN AVENUE INVESTORS, LLC -
                                    ANACAPA FUND

                                    By:      /s/ Michael Browne
                                             -----------------------------------
                                             Michael Browne
                                             Manager

                                    OCEAN AVENUE INVESTORS, LLC -
                                    FOUNDERS FUND

                                    By:      /s/ Michael Browne
                                             -----------------------------------
                                             Michael Browne
                                             Manager

                                    OCEAN AVENUE INVESTORS, LLC -
                                    REDSTONE FUND

                                    By:      /s/ Michael Browne
                                             -----------------------------------
                                             Michael Browne
                                             Manager

                          Address:  100 Wilshire Boulevard, Suite 1850
                                    Santa Monica, CA  90401

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

NEW INVESTORS:                      KINGSBURY CAPITAL PARTNERS, L.P., III

                                    By:      Kingsbury Associates, L.P.,
                                             Its General Counsel

                                    By:      /s/ Timothy J. Wollaeger
                                             -----------------------------------
                                             Timothy J. Wollaeger,
                                             General Partner

                          Address:  3655 Nobel Drive, Suite 490
                                    San Diego, CA  92122

                                    KINGSBURY CAPITAL PARTNERS, L.P., IV

                                    By:      Kingsbury Associates, L.P.,
                                             Its General Counsel

                                    By:      /s/ Timothy J. Wollaeger
                                             -----------------------------------
                                             Timothy J. Wollaeger,
                                             General Partner

                          Address:  3655 Nobel Drive, Suite 490
                                    San Diego, CA 92122

                                    VECTOR LATER-STAGE EQUITY FUND II
                                    (QP), L.P.

                                    By:      Vector Fund Management II, L.L.C.
                                             Its General Partner

                                    By:      /s/ Douglas Reed
                                             -----------------------------------
                                             Douglas Reed, M.D.
                                             Managing Director

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                    VECTOR LATER-STAGE EQUITY FUND II, L.P.

                                    By:      Vector Fund Management, II, L.L.C.
                                             Its General Partner

                                    By:      /s/ Douglas Reed
                                             -----------------------------------
                                             Douglas Reed, M.D.
                                             Managing Director

                          Address:  1751 Lake Cook Road, Suite 350
                                    Deerfield, IL  60015

                                    OCEAN AVENUE INVESTORS, LLC -
                                    ANACAPA FUND I

                                    By:      /s/ Michael Browne
                                             -----------------------------------
                                             Michael Browne
                                             Manager

                                    OCEAN AVENUE INVESTORS, LLC -
                                    FOUNDERS FUND

                                    By:      /s/ Michael Browne
                                             -----------------------------------
                                             Michael Browne
                                             Manager

                                    OCEAN AVENUE INVESTORS, LLC -
                                    REDSTONE FUND

                                    By:      /s/ Michael Browne
                                             -----------------------------------
                                             Michael Browne
                                             Manager

                          Address:  100 Wilshire Boulevard, Suite 1850
                                    Santa Monica, CA  90401

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                    HEALTH CARE INDEMNITY, INC.

                                    By:      Columbia/HCA Healthcare Corporation
                                    Its:     Investment Advisor

                                    By:      /s/ James T. Glasscock
                                             -----------------------------------

                                    Name:    James Glasscock
                                             -----------------------------------

                                    Its:     VP, Investments
                                             -----------------------------------

                          Address:  One Park Plaza
                                    Post Office Box 550
                                    Nashville, TN 37202-0550

                                    AUREUS DIGIRAD, LLC

                                    By:      /s/ Robert M. Averick
                                             -----------------------------------

                                    Name:    Robert Averick
                                             -----------------------------------

                                    Its:     Member
                                             -----------------------------------

                          Address:  100 First Stamford Place
                                    Stamford, CT  06902

                                    MERRILL LYNCH VENTURES, LLC

                                    By:      /s/ Edward J. Higgins
                                             -----------------------------------
                                             Edward J. Higgins
                                             Vice President

                          Address:  2 World Financial Center, 31st Floor
                                    New York, NY 10281
                                    Attn: Robert F. Tully

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                     MID CAROLINA CARDIOLOGY, PA

                                     By:      /s/ Stephen A. McAdams MD
                                             -----------------------------------
                                     Its:     Chief Executive Officer
                                             -----------------------------------
                                     Name:    Stephen A. McAdams
                                             -----------------------------------

                            Address: 1718 East 4th Street, Suite 901
                                     Charlotte, NC  28277
                                     Attn: Stephen A. McAdams

                                     STEPHEN ALAN MCADAMS AND LOU ANN
                                     MCADAMS, AS JOINT TENANTS

                                     By:      /s/ Stephen Alan McAdams
                                             -----------------------------------
                                             Stephen Alan McAdams

                                     By:      /s/ Lou Ann McAdams
                                             -----------------------------------
                                             Lou Ann McAdams

                            Address: 4901 Old Course Drive
                                     Charlotte, NC  28277

                                     AKINYELE ALUKO, M.D.

                                     /s/ Akinyele Aluko
                                     -----------------------------------
                                     Akinyele Aluko, M.D.

                            Address: 5725 Laurium Road
                                     Charlotte, NC  28228

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                     HARVEY FAMILY LLC

                                     By:      /s/ John Harvey
                                             -----------------------------------
                                             John Harvey, M.D.
                                             Manager

                            Address: 2305 NW Grand Boulevard
                                     Oklahoma City, OK  73116

                                     GFP DIGIRAD, LLC

                                     By:      /s/ illegible
                                             -----------------------------------
                                     Its:     Managing Member
                                             -----------------------------------
                                     Name:    /s/ illegible
                                             -----------------------------------

                            Address: 4000 West Brown Deer Road
                                     Milwaukee, WI  53209-1221
                                     Attention:  Bruce Gendelman

                                     DR. JEROME WILLIAMS, JR.

                                     /s/ Jerome Williams, Jr.
                                     -----------------------------------
                                     Dr. Jerome Williams, Jr.

                            Address: 4534 Rosecliff Drive
                                     Charlotte, NC  28277

                                     DWAYNE A. SCHMIDT

                                     /s/ Dwayne A. Schmidt
                                     -----------------------------------
                                     Dwayne A. Schmidt

                            Address: 327 Northwest 14th Street
                                     Oklahoma City, OK  73103

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                     RICHARD N. LINDER AND JUDY F. LINDER

                                     /s/ Richard N. Linder
                                     -------------------------------------------
                                     Richard N. Linder

                                     /s/ Judy G. Linder
                                     -------------------------------------------
                                     Judy F. Linder

                            Address: 805 Polo Run
                                     Collierville, TN  38017

                                     FISK VENTURES LLC

                                     By:     /s/ illegible
                                             -----------------------------------
                                     Its:    Manager
                                             -----------------------------------

                            Address: 4041 North Main Street
                                     Post Office Box 1919
                                     Racine, Wisconsin 53401-1919

                                     INGLEWOOD VENTURES, LP

                                     By:     /s/ Daniel C. Wood
                                             -----------------------------------
                                     Its:    Member
                                             -----------------------------------

                            Address: 12526 High Bluff Drive, Suite 300
                                     San Diego, CA  92130

                                     THE UNIVERSITY OF NORTH CAROLINA AT
                                     CHAPEL HILL FOUNDATION INVESTMENT
                                     FUND, INC.

                                     By:     /s/ Mark W. Yusko
                                             -----------------------------------
                                             Mark W. Yusko

                                     Its:    Assistant Treasurer
                                             -----------------------------------

                            Address: 308 West Rosemary Street, Suite 203
                                     Chapel Hill, NC  27516

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                     PALIVACINNI PARTNERS, LLC

                                     By:     /s/ Peter K. Shagory
                                             -----------------------------------
                                             Peter K. Shagory

                                     Its:    Manager
                                             -----------------------------------

                            Address: 1751 Lake Cook Road, Suite 350
                                     Deerfield, IL  60015

                                     KINGSBURY CAPITAL PARTNERS, L.P.

                                     By:     Kingsbury Associates, L.P.,
                                             Its General Counsel

                                     By:     /s/ Timothy J. Wollaeger
                                             -----------------------------------
                                             Timothy J. Wollaeger,
                                             General Partner

                            Address: 3655 Nobel Drive, Suite 490
                                     San Diego, CA  92122

                                     KINGSBURY CAPITAL PARTNERS, L.P., II

                                     By:     Kingsbury Associates, L.P.,
                                             Its General Counsel

                                     By:     /s/ Timothy J. Wollaeger
                                             -----------------------------------
                                             Timothy J. Wollaeger,
                                             General Partner

                            Address: 3655 Nobel Drive, Suite 490
                                     San Diego, CA  92122

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

<Page>

                                     ANACAPA INVESTORS, LLC -
                                     ANACAPA I

                                     By:     /s/ Rob Raede
                                             -----------------------------------
                                             Rob Raede
                                             Manager

                            Address: 32 W. Anapamu, #350
                                     Santa Barbara, CA  93101

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

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                                     THE ARTHUR & SOPHIE BRODY REVOCABLE TRUST
                                     DATED 4/13/89

                                     By:     /s/ illegible
                                             -----------------------------------
                                     Its:    Trustee
                                             -----------------------------------

                            Address: 990 Highland Drive, Suite 100
                                     Solana Beach, CA  92075-2472
                                     Attn:  Arthur Brody

                                     MALIN BURNHAM

                                     By:     /s/ Malin Burnham
                                             -----------------------------------
                                             Malin Burnham

                            Address: 610 West Ash Street, Suite 2000
                                     San Diego, CA  92101-3350

                                     DERBES FAMILY TRUST UDT DATED 4/25/86

                                     By:     /s/ Daniel W. Derbes
                                             -----------------------------------
                                             Daniel W. Derbes

                                     Its:    Trustee
                                             -----------------------------------

                            Address: c/o Signal Ventures
                                     777 South Pacific Coast Highway,
                                     Suite 107
                                     Solana Beach, CA  92075
                                     Attn:  Dan Derbes

                                     ELLIOT FEUERSTEIN TRUST DATED 5/14/82

                                     By:     /s/ Elliot Feuerstein
                                             -----------------------------------
                                     Its:    Trustee
                                             -----------------------------------

                            Address: 8924 Mira Mesa Boulevard
                                     San Diego, CA  92126
                                     Attn:  Elliot Feuerstein

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

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                                     STANLEY & MAXINE FIRESTONE TRUST
                                     DATED 12/2/88

                                     By:     Stanley Firestone - TTEE
                                             -----------------------------------
                                     Its:    /s/ Stanley Firestone
                                             -----------------------------------

                            Address: c/o Malibu Clothes
                                     259 South Beverly Drive
                                     Beverly Hills, CA  90212
                                     Attn:  Stanley Firestone

                                     THE STANLEY E. AND PAULINE M. FOSTER TRUST
                                     DATED 7/31/81

                                     By:     /s/ Stanley Foster
                                             -----------------------------------
                                     Its:    Trustee
                                             -----------------------------------

                            Address: 705 12th Avenue
                                     San Diego, CA  92101
                                     Attn:  Stanley E. Foster

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

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                                     JOAN P. KATZ TRUSTEE OF NON-EXEMPT TRUST
                                     "C" UNDER IRA R. & JOAN K. KATZ QUALIFIED
                                      MARITAL TRUST

                                     By:     /s/ Joan P. Katz
                                             -----------------------------------
                                     Its:    Trustee
                                             -----------------------------------

                            Address: c/o Evergreen Wealth Management
                                     7911 Herschel Avenue, #311
                                     La Jolla, CA  92037
                                     Attn:  Alan Aielo

                                     KNOWLES FAMILY TRUST

                                     By:     /s/ illegible
                                             -----------------------------------
                                     Its:    Trustee
                                             -----------------------------------

                            Address: c/o Wall Street Property Company
                                     1250 Prospect Avenue, Suite 200
                                     La Jolla, CA  92038
                                     Attn:  Raymond V. Knowles

                                     ARTHUR E. NICHOLAS

                                     By:     /s/ Arthur Nicholas
                                             -----------------------------------
                                     Its:
                                             -----------------------------------

                            Address: c/o Nicholas-Applegate Capital
                                     Management
                                     600 West Broadway, 29th Floor
                                     San Diego, CA  92101
                                     Attn:  Maureen Brown

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

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                                     PAGE TRUST DATED 3/3/89

                                     By:     /s/ illegible
                                             -----------------------------------
                                     Its:    Trustee
                                             -----------------------------------

                            Address: 1904 Hidden Crest Drive
                                     El Cajon, CA  92019
                                     Attn:  Tom Page

                                     FORREST N. SHUMWAY & PATRICIA K. SHUMWAY
                                     MARITAL TRUST DTD 4/26/94

                                     By:     /s/ Forrest Shumway
                                             -----------------------------------
                                     Its:
                                             -----------------------------------

                            Address: 9171 Towne Centre Drive, Suite 410
                                     San Diego, CA  92122-1238
                                     Attn:  Forrest N. Shumway

                     [SIGNATURE PAGE TO AMENDED AND RESTATED
                           SERIES E VOTING AGREEMENT]

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                                   SCHEDULE A
EXISTING INVESTORS
Johnson & Johnson Development Corporation
Kingsbury Capital Partners L.P., III
Sorrento Growth Partners I, L.P.
Sorrento Ventures II, L.P.
Sorrento Ventures III, L.P.
Sorrento Ventures CE, L.P.
Vector Later-Stage Equity Fund, L.P.
Vector Later-Stage Equity Fund II, L.P.
Vector Later-Stage Equity Fund II (Q.P.), L.P.
Ocean Avenue Investors - Founders Fund
Ocean Avenue Investors - Redstone Fund
Ocean Avenue Investors - Anacapa Fund I
Health Care Indemnity, Inc.
Mitsui & Co., Ltd.
MVC Global Japan Fund I
Page Trust DTD 03/03/89
Elliot Feuerstein Trust DTD 05/14/82

NEW INVESTORS
Kingsbury Capital Partners L.P., III
Kingsbury Capital Partners L.P., IV
Vector Later-Stage Equity Fund II, L.P.
Vector Later-Stage Equity Fund II (Q.P.), L.P.
Ocean Avenue Investors, LLC - Anacapa Fund I
Health Care Indemnity, Inc.
Aureus Digirad, LLC
Merrill Lynch Ventures, LLC
Mid Carolina Cardiology, PA
Stephen Alan McAdams and Lou Ann McAdams, As Joint Tenants
Akinyele Aluko, M.D.
Harvey Family LLC
GFP Digirad
Dr. Jerome Williams, Jr.
Dwayne A. Schmidt
Richard N. Linder and Judy F. Linder
Fisk Ventures LLC
Inglewood Ventures, LP
The University of North Carolina at Chapel Hill
      Foundation Investment Fund, Inc.
Palivaccini Partners, LLC
Kingsbury Capital Partners L.P.,
Kingsbury Capital Partners L.P., II
Anacapa Investors, LLC - Anacapa I
Kingsbury Capital Partners, L.P.
Kingsbury Capital Partners, L.P. II

                                                        A-1

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The Arthur & Sophie Brody Revocable Trust dated 4/13/89
Malin Burnham
Derbes Family Trust udt Dated 4/25/86
Elliot Feuerstein Trust Dated 5/14/82
Stanley & Maxine Firestone Trust Dated 12/2/88
The Stanley E. And Pauline M. Foster Trust dtd 7/31/81
Ira R. & Joan P. Katz Qualified Marital Trust
Knowles Family Trust
Arthur E. Nicholas
Page Trust Dated 3/3/89
Forrest N. Shumway & Patricia K.
         Shumway Marital Trust DTD 4/26/94

                                                        A-2

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