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                                                                   EXHIBIT 10.24

                  MASTER LOAN AND SECURITY AGREEMENT NO. 7110
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                               PHOENIXCOR, INC.
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                      MASTER LOAN AND SECURITY AGREEMENT
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     This Master Loan and Security Agreement is entered into as of the 18th day
of June, 1998 by and between Phoenixcor, Inc., a Delaware corporation, having
its principal place of business at 65 Water Street, South Norwalk, Connecticut
06854 (the "Lender") and 3-Dimensional Pharmaceuticals, Inc. a Delaware
corporation having its principal place of business at Eagleview Corporate
Center, 665 Stockton Drive, suite 104, Exton, PA 19341 (the "Borrower". The
Lender and Borrower agree as follows:

     1.   THE LOANS. Subject to the terms and conditions of this Agreement, the
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Lender will make one or more loans to the Borrower upon the terms and conditions
set forth in this Agreement and each schedule which may be executed from time to
time by the parties hereto and identified as a schedule to this Agreement
(individually, a "Schedule" and collectively, the "Schedules") and all
amendments, riders and supplements hereto and thereto. This Agreement and each
Schedule which may be executed pursuant hereto shall constitute a separate and
distinct Loan (each a "Loan" and collectively, the "Loans") repayable as
provided in this Agreement and the applicable Schedule.

     2.   REPAYMENT OF LOANS. Borrower agrees to repay each Loan in the number
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and the amount of successive monthly or quarterly installments (which shall be
inclusive of interest, unless otherwise indicated) reflected in the applicable
Schedule The advance payment with respect to a Schedule, if any, shall be due
and payable upon execution of the Schedule. The first periodic installment
(after excluding the advance payment, if any) with respect to a Schedule shall
be due on the first (1st) day of the month following the advance of the Loan
proceeds by Lender (the "Commencement Date"). The remaining periodic installment
payments shall be due and payable on the same day of each successive month (or
quarter, if quarterly payments are provided for in the Schedule). However, the
parties may select another Commencement Date by noting the same in the Special
Provisions section of the Schedule or by a separate writing signed by Lender and
Borrower in which case the first periodic installment payment shall be due on
such date. The Borrower authorizes the Lender to insert the Commencement Date in
each Schedule, determined in accordance with the foregoing provisions. Unless
otherwise specifically provided for in this Agreement or a Schedule, no Loan may
be prepaid.

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     3.   SECURITY INTEREST. To secure payment when due of the Loan described in
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the applicable Schedule, any interim fundings against such Loan, the performance
of all other obligations of the Borrower under this Agreement and the applicable
Schedule and the payment and performance of any and all other Schedules, debts,
obligations and liabilities of Borrower to Lender whether direct, contingent or
joint and several, now existing or hereafter arising, and any renewals,
extensions and modifications of such debts, obligations and liabilities,
Borrower hereby conveys, assigns and grants to Lender a continuing security
interest in and to (i) the equipment described in the applicable Schedule and
all amendments, riders and supplements thereto including all present and future
additions, attachments, replacements, accessions and accessories thereto (the
"Equipment"), and all substitutions and proceeds thereof including all proceeds
of insurance thereon, and (ii) all other equipment, inventory, accounts,
receivables, goods and assets of any and every kind including, but not limited
to, all items of intangible property, wherever located now or hereafter
belonging -to Borrower or in which Borrower has any interest, and all proceeds
of the foregoing including insurance proceeds all of the above, collectively,
the "Collateral".

     BORROWER GRANTS LENDER THE AUTHORITY TO FILE THIS AGREEMENT AND EACH
SCHEDULE OR A CARBON, PHOTOGRAPHIC OR OTHER REPRODUCTION THEREOF AS A FINANCING
STATEMENT UNDER THE UNIFORM COMMERCIAL CODE WITH RESPECT TO ALL SECURITY
INTERESTS CREATED HEREBY OR THEREBY.

     4.   FINANCING AGREEMENT.  THIS AGREEMENT IS SOLELY A FINANCING AGREEMENT.
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BORROWER ACKNOWLEDGES THAT THE EQUIPMENT HAS BEEN OR WILL BE SELECTED AND
ACQUIRED SOLELY BY BORROWER AND THAT LENDER HAS NOT AND DOES NOT MAKE ANY
WARRANTY WITH RESPECT TO ITS CONDITION, MERCHANTABILITY, SUITABILITY, CAPACITY
OR FITNESS FOR ANY PARTICULAR PURPOSE.

     5.   UNCONDITIONAL OBLIGATION TO PAY, LATE PAYMENTS, ETC. All payments due
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under a Schedule or hereunder shall be paid to Lender or its assigns without
notice or demand and without abatement, offset, defense or counterclaim, at
Lender's principal office shown above, or such other place as Lender or its
assignee may designate in writing to Borrower. Borrower's obligation to pay the
installments and other payments due under a Schedule or hereunder shall be
absolute and unconditional and shall not be affected by reason of (i) any defect
in, lack of fitness for use of, damage to, loss of possession or use of or
destruction of, all or any of the Equipment described in such Schedule; (ii) the
prohibition or other restriction against Borrower's use of said

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Equipment; or (iii) for any other cause, it being the agreement of the parties
that the Loan and any other amount payable by Borrower under a Schedule or
hereunder shall continue to be payable in all events in the manner and at the
times provided in the Schedule and this Agreement.

     All Loans shall become immediately due and payable in their entirety upon
the occurrence of any Event of Default (as defined below). If any periodic
installment payment or other payment is more than five (5) days late, Lender
may, at its election, and subject to prior exercise of its right of
acceleration, accept the payment in arrears and Borrower shall pay, as
liquidated damages, a late charge equal to two (2%) percent per month (computed
on the basis of a thirty (30) day month) on each defaulted payment from the due
date thereof. In no event shall any amount payable to Lender as interest,
including any sum held by a court of competent jurisdiction to be "interest"
under applicable law, exceed, with respect to any period of time, the highest
rate of interest permitted by applicable law. Any amount received by Lender
determined to be in excess of the highest rate of interest received by Lender
shall be refunded to Borrower.

     6.   REPRESENTA11ONS AND WARRANTIES. Borrower warrants and represents as
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follows as of the date hereof and as of the date of execution of each Schedule:
(i) unless it is an individual or sole proprietorship, Borrower is duty
organized, validly existing and in good standing under applicable law and is
duly qualified to do business wherever necessary to carry on its business and
operations and to own Its property; (ii) Borrower has full power and authority
to execute, deliver and perform its obligations under this Agreement and the
Schedules; (iii) the execution and delivery of this Agreement and the Schedules
has been authorized by all requisite corporate (or partnership or company)
action; (iv) the execution, delivery and performance of this Agreement and, the
Schedules do not and will not constitute a breach, default or violation of or
under Borrower's articles of incorporation, by laws (partnership or limited
liability company agreement) or any other agreement, law, order, lease, judgment
or injunction to which it is a party or may be bound; (v) the Equipment is (or,
on the applicable date the Loan proceeds are advanced, will be) lawfully owned
by Borrower, free and dear of all liens, encumbrances and security interests and
Borrower will warrant and defend title thereto against all claims; (vi) no
consent or approval of, notice to, or filing with any governmental authority is
required for Borrower to sign, deliver and perform under this Agreement and each
Schedule; (vii) Borrower has not granted and will not grant to any one other
than Lender a security interest in the Equipment and no Financing Statement or
other instrument affecting the Equipment nor rights therein, bearing the
signature of, or otherwise authorized by, Borrower is on file in any public
office; (viii)

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there are no suits or proceedings pending or threatened, in court or before any
commission, board or other administrative agency against or affecting Borrower
which could, in the aggregate, have a material adverse effect on Borrower, its
business or operations, or its ability to perform its obligations under this
Agreement or the Schedules; (ix) all financial statements delivered and to be
delivered to Lender in connection with the Loans are and will be true and
correct in all material respects and have been and will be prepared in
accordance with generally accepted accounting principles, and since the date of
the most recent financial statements, there has been no material adverse change
in Borrower's financial affairs or business operations and (x) Borrower has
filed all tax returns required to be filed prior to the date of this Agreement
taking into account any extension of time to file granted or permitted by the
taxing authority and Borrower has paid or adequately provided for all taxes
payable by it.

     7.   INDEMNIFICATION BY BORROWER. Borrower shall exonerate and indemnify
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Lender against and hold it harmless from, any and all claims, actions, suits,
proceedings, losses, judgments, damages and liabilities, including reasonable
attorneys' fees and other costs and expenses in connection therewith or incident
thereto, for death of or injury to any person whomsoever and for any loss of or
damage to or destruction of any property whatsoever and irrespective of the
legal basis of such claim or action including the doctrine of strict liability
in tort or any similar doctrine, caused by or arising out of or allegedly caused
by or arising out of, or in any way connected with or resulting from or
allegedly resulting from any of the Equipment, including, without limiting the
generality of the foregoing, the manufacture, selection, delivery, possession,
use, operation, storage or maintenance at any time during the term hereof.
Borrower shall also exonerate and indemnify Lender against and hold it harmless
from any and all claims, actions, suits proceedings, losses, damages and
liabilities, including reasonable attorney's fees, which Lender may suffer by
reason of any patent infringement or alleged patent infringement in connection
with the ownership, use or operation of the Equipment. This covenant of
indemnity shall continue in full force and effect notwithstanding termination of
this Agreement and all Schedules.

     8.   INSURANCE. Borrower shall, at its sole cost and expense, procure and
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maintain, so long as Borrower is indebted to Lender on any Loan or on any other
liability (I) insurance insuring the Equipment against all risks of physical
loss, theft, damage and destruction with extended coverage in an amount equal to
the greater of (a) the amount of the Loan under the applicable Schedule or (b)
the full replacement value of the Equipment with loss payable solely to Lender
(and its assigns) and Borrower as their interests may appear and (ii) personal
injury liability and property damage insurance with respect to the Equipment and
the use thereof in such amounts as may be

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reasonably acceptable to Lender, and naming Lender (and its assigns) as
additional insured. All insurers and coverages must be reasonably satisfactory
to Lender. Borrower shall deposit said policy or policies or duplicates thereof
or certificates of insurance with Lender and said policies shall provide that
the policies may not be cancelled or altered without at least thirty (30) days
prior notice to Lender and that the coverage shall not be invalidated against
Lender because of any violation of any condition or warranty contained in any
policy or application therefor by Borrower or by reason of any action or
inaction of Borrower.

     9.   USE, REPAIRS. LOSS AND DAMAGE. Borrower agrees to maintain the
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Equipment in good condition and repair and in accordance with the manufacturer's
instructions, manuals and warranties (if any) and the requirements of any
applicable insurance and any governmental authority having jurisdiction.
Borrower shall pay for all fuel, service, inspection, overhaul, replacements,
substitutions, material and labor necessary or desirable for the proper use,
repair, operation and maintenance of the Equipment. All risks of loss, theft,
damage or destruction of the Equipment shall be borne by Borrower and Borrower
shall promptly notify Lender in writing of any such loss, theft, damage or
destruction. In the event of any damage to the Equipment (unless the same is
damaged beyond repair) Borrower shall, at its expense, place the same in good
repair, condition and working order. If the Equipment set forth in a schedule or
Schedules is determined by Lender to be lost, stolen or damaged beyond repair,
or should said Equipment be confiscated, seized or the use and title thereof
requisitioned to someone other than Borrower, Borrower shall immediately pay to
Lender in addition to unpaid installments, late charges and other sums past due,
an amount equal to the then remaining periodic installments due under the
Schedule or Schedules covering the said Equipment discounted to present value at
the rate of six (6%) percent per annum, less the net amount of the recovery, if
any, received by Lender from insurance on the Equipment.

     10.  BORROWER'S ADDITIONAL COVENANTS. Borrower hereby covenants and agrees
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as follows: (i) the Equipment will at all times be used only for business or
commercial purposes and will be retained in Borrower's possession at its
principal address set forth above (and not moved therefrom without Lender's
prior written consent) unless otherwise specifically provided in a Schedule and,
if another location is provided in a Schedule, the Equipment will be retained at
and not moved from such other location without Lender's prior written consent;
(ii) Borrower will keep the Equipment free and dear of liens, rights of
distraint, charges and encumbrances or claims of the owner (or lessor) of the
real estate in which the same is installed and any purchaser or present or
future creditor obtaining a lien on such real estate and will, upon Lender's
request, obtain and deliver a waiver of any

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of the foregoing as to the Equipment in recordable form supplied by the Lender
(iii) except for the security interest granted hereby, Borrower will keep the
Equipment free and clear of any security interest, lien or encumbrance and will
not sell, lease, assign (by operation of law or otherwise), exchange or
otherwise dispose of any of the Equipment; (iv) at the request of Lender,
Borrower will affix conspicuous tags or plates on the Equipment containing a
notation with Lender's name and will join Lender in execution of one or more
Financing Statements pursuant to the Uniform Commercial Code to establish and
maintain its security interest in the Collateral, in form satisfactory to
Lender, and will pay any filing fees and/or costs with respect thereto and for
lien searches; (v) Borrower authorizes Lender to file one or more Financing
Statements covering the Collateral without Borrower's signature thereto for the
purposes of continuation and/or termination of existing Financing Statements;
(vi) Borrower will immediately notify Lender in writing of any change in its
place(s) of business or the adoption or change of any trade name or fictitious
business names and will execute any additional Financing Statements as Lender
may request to perfect and maintain its security interest, but such notice shall
not be deemed an authorization to move the Collateral without the prior written
consent of Lender (vii) if any part of the Collateral is subject to a
certificate of title law, Borrower will cause Lender's security interest to be
noted thereon and promptly deliver such certificate of title to Lender (viii)
Borrower will allow Lender and its representatives free access to the Collateral
at all times during normal business hours, for purposes of inspection and,
following an Event of Default, Lender shall have the right to demonstrate and
show the Collateral to others; and (ix) Borrower will furnish to Lender (and
will cause any guarantor of Borrower's obligations hereunder to furnish to
Lender) (a) its unaudited quarterly Financial Statements within thirty (30) days
after the end of its first three quarters in each fiscal year, (b)its certified
annual Financial Statements within ninety (90) days after the close of its
fiscal year, prepared by an independent certified public accountant in
accordance with generally accepted accounting principles and (C) all other
financial information and reports that Lender may from time to time reasonably
request, including income tax returns of Borrower and any guarantor of
Borrower's obligations hereunder.

     11.  CROSS COLLATERALIZAT1ON. Without in any way limiting the provisions of
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Section 3, as additional security for the Borrower's obligations under this
Agreement and any Schedule, Borrower grants to Lender a further security
interest in (I) all of the Equipment and Collateral set forth in every other
Schedule and (ii) all machinery, equipment, goods and other collateral covered
by any other lease, security agreement or loan and security agreement or other
contract (collectively, the "other agreements") between the Borrower and the
Lender

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whether such other agreements are now in existence or hereafter come into
existence and whether such other agreements were originally documented in the
name of Lender or assigned to Lender, and Borrower assigns to the Lender as
security for its obligations under this Agreement and each Schedule, all of its
rights, title and interest in surplus money to which Borrower may be entitled
upon the sale or liquidation of the Equipment and Collateral set forth in every
other Schedule and the machinery, equipment, goods and other collateral covered
by the other agreements.

     Anything above to the contrary notwithstanding, the benefit of the
foregoing cross collateral provisions shall apply to the benefit of the Lender
and any assignees holding a Schedule to this Agreement only to the extent that
the Lender or such assignee is also the holder of one or more Schedules or other
agreements and only to the extent that the Lender or such assignee has retained
or received an assignment of the property described in such other Schedule(s) or
other agreements.

     12.  TAXES AND OTHER CHARGES. Borrower agrees to pay promptly when due all
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registration, title, license and other fees and assessments and all sales, use,
gross receipts, ad valorum, property and any and all other taxes imposed by any
State, Federal, local or foreign government upon this Agreement or upon the
ownership, shipment, delivery, use or operation of the Equipment or any
Collateral or upon or measured by any payments due hereunder (other than taxes
on or measured solely by the net income of Lender) and any fines, penalties and
interest thereon.

     13.  BORROWER'S FAILURE TO PAY TAXES. INSURANCE, ETC. Should Borrower fail
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to make any payment or do any act as herein provided (including, but not limited
to, payment of taxes or for insurance), Lender shall have the right, but not the
obligation, and without releasing Borrower from any obligation hereunder, to
make or do the same, and to pay any sum due in connection therewith or to
contest or compromise any encumbrance, charge or lien and in exercising any such
rights, incur any liability and expend whatever amounts in its absolute
discretion it may deem necessary therefor. All sums so incurred or expended by
Lender shall be payable by Borrower on demand with interest at the rate of two
(2%) percent per month.

     14.  DEFAULT. The occurrence of any one of the following shall constitute
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an Event of Default hereunder and under each Schedule: (I) Borrower fails to pay
any periodic installment payment, or other amount due hereunder or under any
Schedule, when the same becomes due and payable on or before the fifth (5th) day
following the receipt of written notice of non-payment; (ii) Borrower removes,
sells, transfers, encumbers, or parts with

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possession of the Equipment or any items of Equipment or attempts to do any of
the foregoing; (iii) Borrower fails to maintain in force the required insurance
on or in connection with any Equipment in compliance herewith or fails to
provide loss payable protection to Lender in form satisfactory to Lender (iv)
any representation or warranty made by Borrower herein or in any other agreement
between the parties or in any statement given to Borrower shall be materially
untrue; (v) Borrower fails to observe or perform any of the other obligations
required to be observed or permitted by Borrower hereunder or under any Schedule
or other obligation or indebtedness of Borrower to Lender otherwise owing or due
by Borrower to Lender in any other agreement now or hereafter executed between
the parties hereto, and such failure shall continue uncured for twenty (20) days
after written notice thereof to Borrower; (vi) Borrower (a) fails to pay any
indebtedness for borrowed money of the Borrower or any interest or premium
thereon, when due (whether by scheduled maturity, required prepayment,
acceleration, demand or otherwise) or (b) fails to perform or observe any term,
covenant, or condition on its part to be performed or observed under any
agreement or instrument relating to such indebtedness for borrowed money when
required to have been performed or observed, if the effect of such failure to
perform or observe is to accelerate or permit the acceleration of such
indebtedness, or if any such indebtedness shall be declared to be due or payable
or required to be prepaid (other than by a regularly scheduled required
prepayment) prior to the stated maturity thereof; (vii) if Borrower leases the
premises where the Equipment is located, a breach of such lease by Borrower and
the commencement of an action by the landlord to evict Lessee or to repossess
the premises; (viii) Borrower sells, leases or disposes of any of its assets
except in the ordinary course of its business and except for the disposition of
any obsolete property not useful to Borrower; (ix) Borrower ceases doing
business as a going concern, makes an assignment for the benefit of creditors,
admits in writing its inability to pay its debts as they become due, files a
voluntary petition in bankruptcy, is adjudicated a bankrupt or an insolvent,
files a petition seeking for itself any reorganization, arrangement,
composition, readjustment, liquidation, dissolution or similar arrangement under
any present or future statute, law or regulation or files an answer admitting
the material allegations of a petition filed against it in any such proceeding,
consents to or acquiesces in the appointment of a trustee, custodian, receiver
or liquidator of it or of all or any substantial part of its assets or
properties, or if Borrower takes any action looking to its dissolution or
liquidation, or an order for relief is entered under the Bankruptcy Code against
Borrower; (x) if within sixty (60) days after the commencement of any
proceedings against Borrower seeking reorganization, arrangement, readjustment
liquidation, dissolution or similar relief under any present or future statute,
law or regulation, such proceedings, shall not have

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been dismissed or if within sixty (60) days after the appointment, without
Borrower's acquiescence, of any trustee, custodian, receiver or liquidator of it
or of all or any substantial part of Its assets and properties, such appointment
shall not be vacated;(xi) Borrower sells all or substantially all of its assets
or consolidates with or merges into any other entity or Borrower's stockholders,
partners or members sell all or substantially all of their stock or partnership
or membership interests without Lender's prior written consent, which consent
shall not be unreasonably withheld if, in Lender's reasonable business judgment,
the surviving or acquiring entity in the event of such merger or consolidation
has a financial and credit standing equal to or greater than that of Borrower;
or (xii) a guarantor of Borrower's obligations hereunder dies or is dissolved,
or a petition in bankruptcy is filed by or against such guarantor of Borrower's
obligations hereunder or such guarantor defaults in observing or performing any
obligation owing under any guaranty or other agreement with Lender now or
hereafter executed and such default continues uncured for twenty (20) days after
written notice to Borrower and such guarantor.

     15.  REMEDIES. Upon the occurrence of an Event of Default, or at any time
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thereafter, Lender shall have the right to recover from Borrower, as liquidated
damages for loss of a bargain and not as a penalty, a sum equal to the aggregate
of the following: (a) all unpaid periodic installment payments and other sums
due under this Agreement and the applicable Schedule to the date of default plus
late charges, if any, (b) the present value (using a six (6%) percent per annum
discount rate) of all remaining installments due under this Agreement and each
Schedule; and (C) interest on the aggregate of the amounts specified in (a) and
(b) from the date of default at the rate of two (2%) percent per month. In
addition, Lender shall have the right to recover from Borrower any expenses paid
or incurred by Lender in connection with the enforcement of Its rights under
this Agreement and each Schedule and the repossession, transport, insuring,
holding, repair, preparing for sale and subsequent sale, lease or other
disposition of the Collateral including attorney fees and legal expenses as
provided below (collectively, "Repossession Expenses"). BORROWER AND LENDER
WAIVE ANY AND ALL RIGHTS TO A TRIAL BY JURY IN ANY ACTION OR PROCEEDING BASED
UPON THIS AGREEMENT OR RELATING TO THE COLLATERAL. The Lender shall have all of
the rights and remedies of a Secured Party under the Uniform Commercial Code and
Lender is hereby authorized and empowered, with the aid and assistance of any
person or persons, to enter any premises where the Collateral or any part
thereof is, or may be, placed, and to assemble and/or remove same and/or to
render it unusable and sell and dispose of such Collateral at one or more public
or private sales upon at least seven (7) days written notice to Borrower for
such sale. The Lender toward the payment of the

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Repossession Expenses shall apply the proceeds of each such sale; the liquidated
damages specified above and other indebtedness secured hereby. Should the
proceeds of any such sale be insufficient to fully pay all the items above
mentioned Borrower hereby covenants and agrees to pay any deficiency to the
Lender but nothing herein contained shall be construed to require Lender to sell
any Collateral before seeking damages from Borrower. If Lender employs counsel
for the purpose of effecting collection of any monies due hereunder (whether or
not Lender has retaken the Collateral or any part hereof) or for the purpose of
recovering the Collateral, or for the purpose of protecting Lender's interest
because of any default of Borrower or because Lender is named as a party to a
legal proceeding commenced against Borrower, whether or not Borrower is in
default, Borrower agrees to pay Lender's reasonable attorney's fees and legal
costs and expenses inclusive of those incurred in connection with bankruptcy
proceedings, including relief from stay motions, cash collateral motions and
disputes concerning any proposed disclosure statement and/or bankruptcy plan.
The Lender may require Borrower to assemble the Collateral and make it available
to Lender at a place to be designated by Lender which is reasonably convenient
to both parties. All rights and remedies hereunder are cumulative and not
exclusive and a waiver by Lender of any breach by Borrower of the terms,
covenants, and conditions hereof shall not constitute a waiver of future
breaches or defaults, and no failure or delay on the part of Lender in
exercising any of its options, powers, rights or remedies, or partial or single
exercise thereof, shall constitute a waiver thereof. If any court of competent
jurisdiction determines that any provision of this Section 15 is invalid or
unenforceable in any jurisdiction, in whole or in part, such determination, as
to such jurisdiction, shall not prohibit Lender from enforcing its rights and
establishing its damages sustained as the result of any breach of this Agreement
in accordance with the laws of such jurisdiction.

     16.  ASSIGNMENT. Lender may grant security interests in or otherwise assign
          ----------
or transfer (or grant participations in) all or any part of this Agreement or
any Loan or Schedules hereto or any installments or other sums due or to become
due hereunder, without Borrower's consent. In the event Lender transfers any
Schedule, Lender shall deliver a copy of this Agreement to the assignee along
with the manually executed copy of the transferred Schedule marked "Original".
In such event, (i) the copy of this Agreement together with the said Original
Schedule shall constitute chattel paper under the Uniform Commercial Code, (ii)
the terms of this Agreement shall be deemed incorporated in the transferred
Schedule and (iii) the assignee holding the assigned Schedule (which together
with the copy of this Agreement shall constitute a single agreement) shall be
the Lender of the Loan set forth in such assigned Schedule secured by the
Collateral described therein and may exercise its rights

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and remedies with respect thereto separately and independently of the holder of
this Agreement and any other Schedules. Unless specifically transferred by
Lender to the assignee in Lender's assignment to the assignee, the assignee
shall not have any interest in the portion of the Collateral described in
Section 3 (ii) of this Agreement. In the event Lender transfers any Schedule,
Borrower agrees that the right of the assignee to receive installment payments
and other amounts payable under the assigned Schedule as well as any other right
of the assignee shall not be subject to any defense, set-off or counterclaim
which Borrower may have against Lender. Upon Lender's giving notice to Borrower
of any such assignment, Borrower shall promptly acknowledge its obligations
hereunder to the assignee, and shall comply with the written directions or
demands of such assignee, shall make all installment payments and other payments
due with respect to the assigned Schedule as such assignee may direct in writing
and shall send all notices provided for or permitted under this Agreement with
respect to such Schedule to such assignee. Following any such assignment the
term "Lender" shall, as to the assigned Schedule, be deemed to refer to Lender's
assignee, but no such assignee shall be deemed to assume any obligation or duty
imposed upon Lender hereunder and Borrower shall look only to Lender for
performance thereof. As used in this Section 16, "assign" shall be deemed to
include a pledge, sale of, or grant of a mortgage on, or a Security interest in,
any of the Collateral or a Schedule by Lender and the term "assignee" shall be
deemed to refer to the recipient of such pledge, hypothecation, sale, mortgage,
or security Interest. This Agreement and Borrower's interest herein and in any
Schedule shall not be transferable or assignable by Borrower without the
Lender's express prior written consent and any such purported assignment by
Borrower other than in compliance with the provisions of this Section 16 shall
be null and void ab initio.

     17.  SECURITY DEPOSIT. Lender may, at its option, apply the Security
          ----------------
Deposit, if any is indicated in a Schedule, to cure any default of Borrower,
whereupon Borrower shall promptly restore such Security Deposit to its original
amount. Lender may also apply the Security Deposit to any sums owing by Borrower
under Section 15 hereof including the liquidated damages. Lender shall return to
Borrower any unapplied Security Deposit without interest upon full payment and
performance of Borrower's obligations hereunder and under all Schedules hereto.

     18.  GENERAL PROVISIONS. THE OBLIGATION OF THE LENDER TO MAKE ONE OR MORE
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LOANS HEREUNDER IS SUBJECT TO LENDER'S CREDIT APPROVAL COLLATERAL APPRAISALS AND
SUCH OTHER CRITERIA AS LENDER MAY IN ITS SOLE AND ABSOLUTE DISCRETION DETERMINE.
No person except a duly authorized officer of Lender shall have any power to

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modify, amend or waive any of the provisions hereof. All the Borrower's
covenants herein shall survive the termination of this Agreement. Notices
hereunder shall be in writing and shall be deemed given when personally
delivered, delivered by overnight carrier or sent by facsimile to a party's
facsimile number, or three days after having been mailed to the other party at
the address specified for each herein or to such other address as either party
may, from time to time, provide, in writing to the other party. Forbearance or
indulgence by Lender in any regards shall not constitute a waiver of the
covenant or condition to be performed by Borrower to which the same may apply.
The section headings are for convenience and are not a part of this Agreement
The Lender is authorized and empowered to date this Agreement and the Schedules
and to fill in blank spaces in accordance with the terms of the transaction,
including, but not limited to, dates, serial numbers, Equipment descriptions and
the assignment of an account number. This Agreement shall be binding upon and
inure to the benefit of the heirs, executors, administrators, successors and
permitted assigns of the parties, and shall be subject to modification only by
agreement in writing between the parties. Any provision of this Agreement which
is prohibited or unenforceable in any jurisdiction shall, as to such
jurisdiction, be ineffective to the extent of such prohibition or
unenforceability without invalidating the remaining provisions hereof. THIS
AGREEMENT AND THE RIGHTS AND OBUGATIONS OF THE PARTIES SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF CONNECTICUT. This
agreement may not be terminated, modified or amended, nor shall any waiver of
any provisions herein be deemed to have occurred regardless of the action or
non-action of the Lender in connection therewith except upon written agreement
of the parties. THIS AGREEMENT, THE SCHEDULES HERETO AND ANY OTHER WRITTEN
AGREEMENTS EXECUTED SIMULTANEOUSLY HEREWITH OR SIMULTANEOUSLY WITH THE EXECUTION
OF A SCHEDULE SUPERSEDE ANY PRIOR PORPOSAL LETTERS, COMMITMENT LETTERS OR
NEGOTIATIONS AND THERE ARE NO ORAL COVENANTS OR AGREEMENTS. This Agreement and
any Schedule shall not be binding upon the Lender until accepted and executed on
behalf of Lender at its South Norwalk, Connecticut office.

"LENDER"                                 "BORROWER"

PHOENIXCOR, INC.                         3-DIMENSIONAL PHARMACEUTICALS, INC.

/s/ Thomas J. Williams                   /s/ Scott Horvitz
---------------------------              ------------------------

BY: Thomas J. Williams                   BY: Scott Horvitz
   ------------------------                 ---------------------

TITLE: Executive Vice President          TITLE: Vice President, Finance
      -------------------------                ------------------------

                                       12
<PAGE>

                                   EXHIBIT A
                    EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

                SCHEDULE TO MASTER LOAN AND SECURITY AGREEMENT
                ----------------------------------------------

MASTER LOAN AND SECURITY AGREEMENT NO.7110           DATED: June 18, 1998
                                      ----                  -------------
SCHEDULE NO.01                                       DATED: June 18, 1998
            --                                              -------------
<TABLE>
<S>                                          <C>
-----------------------------------------------------------------------------------------------
LENDER:      PHOENIXCOR, INC.                BORROWER:     3-Dimensional Pharmaceuticals, Inc.
             65 WATER STREET                               Eagleview Corporate Center,
             SOUTH NORWALK, CT 06854                       665 Stockton Drive, Suite 104
                                                           Exton, PA 19341
</TABLE>

Equipment Location (if other than above address of Borrower): n/a
                                                              ---

     Lender and Borrower have entered into a Master Loan and Security
Agreement No. 7110 dated June 18, 1998 (the "Master Loan Agreement") which is
incorporated herein and this is a Schedule to the Master Loan Agreement. All
words and terms used herein and not specifically defined herein shall have the
same meanings as set forth in the Master Loan Agreement.

     1.   THE LOAN AND LOAN REPAYMENT. As requested by Borrower and pursuant
to the Master Loan Agreement, Lender agrees to lend to Borrower the sum of one
                                                                           ---
million six hundred forty-eight thousand two hundred six dollars and three
--------------------------------------------------------------------------
cents. Borrower agrees to repay the Loan in successive installments (which
-----
installment payments are inclusive of interest) as set forth in the following
Schedule:

<TABLE>
<S>                                                        <C>
                                    SCHEDULE
-----------------------------------------------------------------------------------------------
Advance Payment Amount:                                    $40,671.13
Number of Installments (Exclusive of Advance Payment):     46
Payment Period:                                             X Monthly ___Quarterly
                                                           ---
Periodic Installment Payment Amount Per Period:            $40,671.13;
                                                           -----------
         Followed by One Monthly Installment Payment of    $164,820.60
                                                           -----------

-----------------------------------------------------------------------------------------------
Commencement Date: July 1, 1998                            Security Deposit (if any): none
Special Provisions: (if any): none
</TABLE>

     2.   SECURITY. As security for Borrower's obligations under this Schedule
and the obligations contained in the Master Loan Agreement, the Borrower gives
and grants to the Lender a security interest in the Equipment described in the
attached Exhibit A.

     3.   LOAN DISBURSEMENT. Borrower hereby authorizes Lender to disburse the
Loan proceeds advanced pursuant to this Schedule as follows:

     $1,648,206.03         To: 3-Dimensional Pharmaceuticals, Inc.
     -------------             -----------------------------------
     $1,648,206.03         TOTAL PROCEEDS
     -------------

By execution hereof, the signer certifies that he/she is a duly authorized
officer, partner or proprietor of Borrower and that he/she had read, accepted
and duly executed this Schedule to the Master Loan Agreement on behalf of
Borrower.

                                3-Dimensional Pharmaceuticals, Inc., (Borrower)
                                ------------------------------------

                                BY:_________________________________
                                ____________________________________
                                Print Name and Title

ACCEPTED AT LENDER'S OFFICE AT
SOUTH NORWALK, CONNECTICUT

PHOENIXCOR, INC. (Lender)

BY: _____________________

                                      13
<PAGE>

                                   EXHIBIT A
                    EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

_________________________
Print Name and Title

                                      14
<PAGE>

                                   EXHIBIT A

         The following description of property supplements, and is part,
Schedule No. 01 dated June 18, 1998 to Master Loan and Security Agreement No.
7110 dated June 18, 1998 between the undersigned Borrower and Phoenixcor, Inc.
and may be attached to said Loan Schedule and any related UCC Financing
Statements, Acceptance or Delivery Certificate or other document describing the
property:

                         See Attached Exhibit A Schedule

All property listed above complete with any and all attachments, accessions,
additions, replacements, improvements, modifications and substitutions thereto
and therefor and all proceeds including insurance proceeds thereof and
therefrom.

PHOENIXCOR, INC.                   3-Dimensional Pharmaceuticals, Inc.
----------------                   -----------------------------------
(Lender)                           (Borrower)

BY: /s/ Thomas J. Williams         BY: /s/ Scott Horvitz
   ------------------------           ----------------------

TITLE: Executive Vice President    TITLE: Vice President, Finance
      -------------------------          ------------------------

                                      15
<PAGE>

<TABLE>
<CAPTION>
                   EXHIBIT A
    EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM
--------------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
--------------------------------------------------------------------------------------------------------------------------
Supplier             Description                            Qty        Serial No.  Price        Extended     Sub-Total
                                                                                                  Price
--------------------------------------------------------------------------------------------------------------------------
<S>                  <C>                                    <C>        <C>         <C>          <C>           <C>
Advanced Chemtech    1 lock, ASM, 96 Well H/C Rv, Tfe       1               97176  5,500.00     5,500.00
                     Shipping & Handling                                                           40.00       5,540.00

--------------------------------------------------------------------------------------------------------------------------
Beckman              JLA-10.500 Rotor Assy                  1             97U1767  6,120.00     6,120.00
                     Insurance                                                                     18.36
                     Freight & Handling                                                            24.97       6,163.33
--------------------------------------------------------------------------------------------------------------------------
BMG Lab              Polar star                             1                      45,000.00   45,000.00
                     Incubation Chamber POLARstar           1                       3,000.00    3,000.00
                     Reagent Injector POLARstar             2                       3,500.00    7,000.00
                     Robotics Plate Transport               1                           0.00        0.00
                     Shipping & Handling                                              125.00      125.00      55,125.00
--------------------------------------------------------------------------------------------------------------------------
Bodhan Automation    AWS-100S Weighting Workstation         1                      15,500.00   15,500.00
                                                                                                  758.67      16,258.67
--------------------------------------------------------------------------------------------------------------------------
CAVARO               Automated Tip Washing Stations         3            62113804   2,590.00    7,770.00
                                                                         62114804
                                                                         66340804

                     Automated Tip Washing Station          1                       7,210.00    7,210.00      14,980.00
--------------------------------------------------------------------------------------------------------------------------
Charbdis             Filtration Reactor Kit, 96 wells, red  2                       3,157.50    6,315.00
                     Filtration Reactor Kit, 96 wells,      2
                     green                                                          3,157.50    6,315.00
                     Filtration Reactor Kit, 96 wells,      1
                     purple                                                         3,157.50    3,157.50
                     Filt Rxn & Vac Man, Kit, 96 wells,     1
                     purple                                                         4,210,00    4,210.00
                     M-T Filt Rxn Kit 96 wells, blue        1                       4,407.50    4,407.50
                     M-T Filt Rxn Kit                       1                       4,407.50    4,407.50
                     M-T Filt Rxn Kit 96 wells, green       1                       4,407.50    4,407.50
                     M-T Filt Rxn Kit 96 wells, purple      1                       4,307.50    4,307.50
                     M-T Filt Rxn Kit 96 wells, red                                 4,307.50    4,307.50
                                                  Discount                                       -922.85
                     Shipping & Handling                                                           82.75      45,302.40
                     ILIAD PS Personal Synthesis System     1                      44,000.00   44,000.00
                     Julabo FP-50P System                   1                       8,000.00    8,000.00
                     Shipping and Handling                                                      1,019.55      53,019.55
                     Calypso 4X Shaker System               1                       7,500.00    7,500.00
                     Shipping and Handling                                                        249.21       7,749.21
--------------------------------------------------------------------------------------------------------------------------
Coulter              Dual Threshold Packed                  1                      12,675.00   12,675.00
                     PKG Reaent Starter Kit                 1                         367.00      367.00
                     Delivery, Sys, Integration                                                   350.00      13,392.00

<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
-----------------------------------------------------------------------------------------------------------------------------
Supplier             Description                                  PO No.       Invoice     Invoice     PD        Ck
                                                                               No.         Date        CK #      Amount
-----------------------------------------------------------------------------------------------------------------------------
<S>                  <C>                                          <C>          <C>          <C>        <C>      <C>
Advanced Chemtech    1 lock, ASM, 96 Well H/C Rv, Tfe             ZW972158     42647-IN     11/3/97    cc7703   $ 5,735.00
                     Shipping & Handling

-----------------------------------------------------------------------------------------------------------------------------
Beckman              JLA-10.500 Rotor Assy                        BS972397   323276Cl01    12/12/97    cc785    $ 8,078.33
                     Insurance                                    972397A
                     Freight & Handling
-----------------------------------------------------------------------------------------------------------------------------
BMG Lab              Polar star                                   DG980744         1198     3/20/98   cc8649    $55,125.00
                     Incubation Chamber POLARstar
                     Reagent Injector POLARstar
                     Robotics Plate Transport
                     Shipping & Handling
-----------------------------------------------------------------------------------------------------------------------------
Bodhan Automation    AWS-100S Weighting Workstation               DD980821         9093     5/26/98

-----------------------------------------------------------------------------------------------------------------------------
CAVARO               Automated Tip Washing Stations               JK980683        68062     4/17/98
                                                                  JK980683         6802     4/17/98    8807

                     Automated Tip Washing Station
-----------------------------------------------------------------------------------------------------------------------------
Charbdis             Filtration Reactor Kit, 96 wells, red        DD972201      1711030    11/26/97    cc702    $45,302.40
                     Filtration Reactor Kit, 96 wells,
                     green
                     Filtration Reactor Kit, 96 wells,
                     purple
                     Filt Rxn & Vac Man, Kit, 96 wells,
                     purple
                     M-T Filt Rxn Kit 96 wells, blue
                     M-T Filt Rxn Kit
                     M-T Filt Rxn Kit 96 wells, green
                     M-T Filt Rxn Kit 96 wells, purple
                     M-T Filt Rxn Kit 96 wells, red
                                                     Discount
                     Shipping & Handling
                     ILIAD PS Personal Synthesis System           DH972296      I712005    12/10/97    cc7868   $53,019.55
                     Julabo FP-50P System
                     Shipping and Handling
                     Calypso 4X Shaker System                     DH972296      I801004     1/14/98    cc8005   $ 7,599.21
                     Shipping and Handling
-----------------------------------------------------------------------------------------------------------------------------
Coulter              Dual Threshold Packed                        CM981302       259951     5/19/98
                     PKG Reaent Starter Kit
                     Delivery, Sys, Integration
</TABLE>

                                      16
<PAGE>

                                   EXHIBIT A
                    EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                   Extended         Sub-
Supplier             Description                                    Qty   Serial No.  Price          Price         Total    PO No.
====================================================================================================================================
<S>                  <C>                                            <C>   <C>         <C>         <C>            <C>       <C>
Culligan             Softener Including Installation                 1                2,858.00     2,858.00       2,858.00  BW98062
===================================================================================================================================
DELL                 Dell 6400 P11/MT Workstation 410 Base           1                5,455.00     5,455.00                 DA98124
                     W/Integrated 3 Com Fast Etherlink XL
                     10/100MB/s Sound blaster Compatible
                     Audio Keyboard, 384MB ECC Ram 3 Dimms, 2/nd/
                     Processor for Wkstn 400 MHZ, CD-Rom  Dr.
                     For Win NT, Vdio Card, Monitor, 9/1GBSCSI
                     1, Vdu2W 7200 RPM Hr Dr. Wkstn 410, 3.5"
                     1.44MB Floppy & Diagnostics, Windows NT
                     OPTI 40CD, Cd Documentation
                     Freight                                                                         100.00       5,555.00
===================================================================================================================================
Document             Phaser 350 24MB Version 600x300 wppm            1                1,975.00     1,975.00       1,975.00  JS971615
===================================================================================================================================
Executone Info       Telephone System Upgrade                        1                            30,549.31                JP971768
System               228 Cabnet, 10 Modcel 18 phones, 10
                     Model 32 Phones, Co Car, Station Cards,
                     Expansion of Voicemail, including                                                           30,549.31
                     cable & Hardware
                     12 Port Single Line Card                        1                1,316.00     1,316.00
                     Tri Out Power Supply                            1
                     Sales Tax                                                                        78.96       1,394.96
===================================================================================================================================

Fisher Scientific    Vacuum Pump 5.6 CFM DL                          1                1,725.00     1,725.00
                     Vacuum Pump 115 Vac 60HZ                        1                1,028.50     1,028.50       2,753.50

                     Centrifuge MDL, 5415c 115V                      1                1,805.06     1,805.06       1,805.06

                     Rotvapor 29/42 R124C                            1                3,950.00     3,950.00
                     Balance 2100G x 0.1G Std.                       1                1,603.82     1,603.82
                     Balance Std. LV 210GXD-1MG                      1                2,416.01     2,416.01
                     Vacuum Pump 5.6 CFM MDL                         1                1,162.92     1,162.92       9,132.75

                     Rotvapor 29/42                                  1                3,971.91     3,971.91       3,971.91

                     Refrig Circtr Rm6B 115V                         2                1,879.90     3,759.80       3,759.80

                     Vacuum Pump 5.6 CFM MDL                         1                1,380.00     1,380.00       1,380.00

                     Vaccum Ovel Mdl 285A 120V                       1                1,780.68     1,780.68
                     Microlab 1000 Plus Comp                         1                5,477.53     5,477.53       7,258.21

                     Rotvapor 24/40                                  3                3,688.20    11,064.60
                     Pump Diaphrm Cor Res 171                        3                  632.00     1,896.00
                     Complete Vacuum Rack Sys                        1                2,060.40     2,060.40
                     Refrig/Freezer                                  1                1,111.64     1,111.64

<CAPTION>
----------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
                     Exton, PA  19341
Equip Location       Exton, PA  19341
----------------------------------------------------------------------------------------------------------------------
                                                                     Invoice       Invoice         PD            Ck
Supplier             Description                                     No.           Date          CK #        Amount
======================================================================================================================
<S>                  <C>                                             <C>           <C>           <C>        <C>
Culligan             Softener Including Installation                 33337          3/31/98      cc8664     $2,858.00
======================================================================================================================
DELL                 Dell 6400 P11/MT Workstation 410 Base           159159961      5/12/98
                     W/Integrated 3 Com Fast Etherlink XL
                     10/100MB/s Sound blaster Compatible
                     Audio Keyboard, 384MB ECC Ram 3 Dimms, 2/nd/
                     Processor for Wkstn 400 MHZ, CD-Rom Dr.
                     For Win NT, Vdio Card, Monitor, 9/1GBSCSI
                     1, Vdu2W 7200 RPM Hr Dr. Wkstn 410, 3.5"
                     1.44MB Floppy & Diagnostics, Windows NT
                     OPTI 40CD, Cd Documentation Freight
======================================================================================================================
Document             Phaser 350 24MB Version 600x300 wppm            206818         7/12/98      cc8110     $2,569.39
======================================================================================================================
Executone Info       Telephone System Upgrade                        174471        10/28/97      cc7733     $16,802.12
System               228 Cabnet, 10 Modcel 18 phones, 10                                         cc7374     $13,747.19
                     Model 32 Phones, Co Car, Station Cards,
                     Expansion of Voicemail, including
                     cable & Hardware
                     12 Port Single Line Card                        175082        11/25/97      cc7990      $1,471.28
                     Tri Out Power Supply
                     Sales Tax
======================================================================================================================
                                                                     278404103      11/3/97      cc7734      $28,926.16
Fisher Scientific    Vacuum Pump 5.6 CFM DL                          197
                     Vacuum Pump 115 Vac 60HZ
                                                                     278404051      5/18/98
                     Centrifuge MDL, 5415c 115V                      598
                                                                     478404093      10/2/97      cc7519      $23,160.39
                     Rotvapor 29/42 R124C                            97
                     Balance 2100G x 0.1G Std.
                     Balance Std. LV 210GXD-1MG
                     Vacuum Pump 5.6 CFM MDL
                                                                     278404103      11/3/97
                     Rotvapor 29/42                                  197
                                                                     278404101     10/16/97      cc7629       $7,847.45
                     Refrig Circtr Rm6B 115V                         597
                                                                     278404103      11/3/98
                     Vacuum Pump 5.6 CFM MDL                         197
                                                                     278404111     11/17/97      cc7738      $13,669.26
                     Vaccum Ovel Mdl 285A 120V                       597
                     Microlab 1000 Plus Comp
                                                                     278404033       4/2/98      cc8676      $22,986.01
                     Rotvapor 24/40                                  198
                     Pump Diaphrm Cor Res 171
                     Complete Vacuum Rack Sys
                     Refrig/Freezer
</TABLE>

                                      17
<PAGE>

                                   EXHIBIT A
                    EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
-----------------------------------------------------------------------------------------------------------------------------------
                                                                                                 Extended        Sub-
Supplier             Description                           Qty        Serial No.    Price          Price        Total       PO No.
-----------------------------------------------------------------------------------------------------------------------------------
<S>                  <C>                                   <C>    <C>              <C>          <C>           <C>         <C>
                     Oven Isotemp Std 5 Cuft                1                       1,005.74      1,005.74          1
                     Vacuum Pump DDC200 115/2               1                        2223.48      2,223.48     19,361.86

                     Air Pnel 4-man w/e O. monitor          1                       1,450.00      1,450.00      1,450.00
===================================================================================================================================
                                                                    GDBPPRO300PI    3,398.00      3,398.00                 DA980145
Gateway 2000         GP6-300 System x/MMX                   1                  C
                     Freight and handling                                                            60.00      3,458.00
                     GP6-333 System                         1             1001261   2,994.00      2,994.00                 VK980502
                     Freight & Handling                                                              95.00      3,089.00
===================================================================================================================================
Harrison Res.        Chromatiotron Complete w/pump          1                       4,245.00
===================================================================================================================================
Hemco Corp.          36" Stainless Steel Island Canopy      1                       1,560.00      1,560.00                 BW980551
                     Vinyl Canopy Strip Wall                8                          25.00        200.00      1,760.00
===================================================================================================================================
Jobin Vyon           Flurolog 3 System                      1                      46,000.00     46,000.00                 6P980604
Instruments          Software, Datamax                      1                       2,195.00      2,195.00
Instruments          Software, Datamax Standard Version     1                       1,295.00      1,295.00
                     22.5 Front Face Viewing Accessory      1                       2,100.00      2,100.00
                     Fiber Optic Platform assy              1                       6,995.00      6,995.00
                     Micromax Microwell Plate reader        1                       5,280.00      5,280.00
                     Dual Auto Polarizer                    1                                         0.00
                     Sample Compartment Accessory
                     Electronics                            2                         200.00        400.00
                     Sample Cell                            1                         320.00        320.00
                     Cuvette, Small Quartz for 1931B        1                         200.00        200.00
                     Micro Cell                             1                         160.00        160.00
                     Adapter                                1                       6,300.00      6,300.00
                     One time only purchased sample         1                       1,300.00      1,300.00
                     Heater/cooler
                     Temperature Control Interface Kit      1                       2,200.00      2,200.00
                                                  Discount                                       -8,905.00
                     Packaging & Handling                                                           693.00     66,533.00
===================================================================================================================================
IPSi                 Dolphin 512K Flash 512 Ram Scanners    4           03722DLP    1,455.00      5,820.00                 FJ971257
                     Dolphin Home Base                      4                327      355.00      1,420.00
                                                                                     1416
                                                                                     1485
                     Batch Simplicity "c" Code              1                         855.00        855.00      8,095.00
                     Programming Sftw
                     Dolphin                                4           01098DLP    1,455.00      5,820.00                 EJ981047
                                                                        03002DLP
                                                                        10854DLP
                                                                        12519DLP
                     Dolphin Home Base                      4           06687DHB      355.00      1,420.00
                                                                        06830DHB
                                                                        06866DHB
                                                                        06869DHB
                     Shipping & Handling                                                             30.00      7,270.00

<CAPTION>
---------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
---------------------------------------------------------------------------------------------------------------
                                                                Invoice       Invoice        PD           Ck
Supplier             Description                                   No.        Date         CK #       Amount
---------------------------------------------------------------------------------------------------------------
<S>                  <C>                                        <C>           <C>          <C>       <C>
                     Oven Isotemp Std 5 Cuft
                     Vacuum Pump DDC200 115/2
                                                                278404043
                     Air Pnel 4-man w/e O. monitor              098            5/1/98
===============================================================================================================
                                                                               2/3/98      cc8402    $3,458.00
Gateway 2000         GP6-300 System x/MMX                       26569538
                     Freight and handling
                     GP6-333 System                             28248838       3/2/98      cc8535    $3,089.00
                     Freight & Handling
===============================================================================================================
Harrison Res.        Chromatiotron Complete w/pump
===============================================================================================================
Hemco Corp.          36" Stainless Steel Island Canopy          P27667         4/9/98      cc8685    $1,838.61
                     Vinyl Canopy Strip Wall
===============================================================================================================
Jobin Vyon           Flurolog 3 System                          100142640     5/22/98
Instruments          Software, Datamax
Instruments          Software, Datamax Standard Version
                     22.5 Front Face Viewing Accessory
                     Fiber Optic Platform assy
                     Micromax Microwell Plate reader
                     Dual Auto Polarizer
                     Sample Compartment Accessory
                     Electronics
                     Sample Cell
                     Cuvette, Small Quartz for 1931B
                     Micro Cell
                     Adapter
                     One time only purchased sample
                     Heater/cooler
                     Temperature Control Interface Kit
                                                  Discount
                     Packaging & Handling
===============================================================================================================
IPSi                 Dolphin 512K Flash 512 Ram Scanners        101097-02    10/10/97      cc7637    $8,095.00
                     Dolphin Home Base

                     Batch Simplicity "c" Code
                     Programming Sftw
                     Dolphin                                    042898-01     4/28/98

                     Dolphin Home Base

                     Shipping & Handling
</TABLE>

                                      18
<PAGE>

                                    EXHIBIT A
                     EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
-----------------------------------------------------------------------------------------------------------------------------------
                                                                                                 Extended
Supplier             Description                            Qty        Serial No.  Price           Price      Sub-Total    PO No.
===================================================================================================================================
<S>                  <C>                                    <C>     <C>            <C>          <C>           <C>          <C>
LF Systems           Stainless Steel Table w/Mer Top        1                      1,129.00     1,129.00       1,129.00    Fl971643
===================================================================================================================================
Mac Warehouse        32MB 168 PIN EDO DIMM                  1                        125.00       125.00                   JS971769
                     32 MB 168 PIN EDO DIMM                 1                        125.00       125.00
                     Daynaport E/PCI-T Ethernet Card        2                         44.00        88.00         338.00
                     Power MAC 4400/200 32MB/2GB            1        SXA7220J29GG  1,510.00     1,510.00                   JS971969
                     Mon Apple Multscan 1SAV 15"            1        SCY73227Y6UC    370.00       370.00       1,880.00
                     Mon Poweruser 17                       2                        419.00       838.00         838.00    Js971969
                                                                    60F58A7370029
                     Supermac C600E/200                     1                  24  1,150.00     1,150.00       1,150.00    JS971969
                                                                    60F58A7370029
                     Supermac C600E/200                     1                  77  1,150.00     1,150.00       1,150.00    JS971969
                     MT0903 MON Sony Trinitron Multiscan    1         S017146223B    870.00       870.00         870.00    JS971785
                     MEM PNY 32MB                           1                        300.00       300.00                   JS971823
                     Etherlink 111                          1                        250.00       250.00
                     Carrying Case Notepac - Black          1                         32.00        32.00
                     Portable Printer/Scanner               1                        285.00       285.00         867.00
                     Lap Pro 440CDX                         1           S87209112  2,299.00     2,299.00       2,299.00    JS971823
                                                                      SA735BNX2H0
                     CPU Presario 4824 P2/233               1                  80  2,295.00     2,295.00                   JS971971
                     MON Sony 200SF 17"                     1         SO18164189N    685.00       685.00       2,980.00
                     CPU Compac Deskpro 2000                1       S6738BK72$581  1,380.00     1,380.00       1,380.00    JS972042
                     Power Base 240MH Tower                 1             1491944  1,170.00     1,170.00                   JS972154
                     Mon Poweruser 17                       1                        409.00       409.00      $1,579.00
                     Mon Princeton 17"                      1           872131088    435.00       435.00         435.00    JCS97229
                     Power Base 240MHX Tower                1             1494262  1,170.00     1,170.00       1,170.00    JSC97229
                     Starmax 300MT 603E                     1            STO75817    888.00       888.00       JS(72470    JS972470
                     Mon Princeton 17"                      1           872131078    435.00       435.00       1,323.00
                     Superstack II Switch 3000              1                      2,129.00     2,129.00                   JS972471
                     Superstack II 1000 Baxe TX             1                      1,085.00     1,085.00
                     FE104 4 port 100 Base TX Hub w/uplink  1                        179.95       179.95
                     Surgestation Pro 8                     3                         29.00        87.00       3,480.95
                     Mon Princeton 17"                      2                        435.00       870.00                   JS972496
                     Bundle HP Laserjet Powerprint          1                        445.00       445.00       1,315.00
                     Powerbook 2400C/180                    1        S157310PZAJN  2,865.00     2,854.00       2,865.00    JS972496
                     Starmax 300MT                          1            ST075428    888.00       888.00         888.00    JS972496
                     Bundle HP Laserjet Powerprint          1                        445.00       445.00         445.00    JS972496
                     Starmax 5500MT                         1            ST074693  1,550.00     1,550.00       1,550.00    JCS97258
                     Starmax 5500MT                         2            ST074682  1,550.00     3,100.00                   JCS97258
                                                                         ST070269                   0.00
                     Shipping                                                                      10.00       3,110.00
                     Power Mac 4400/200 32MB                1        SXB7462649GG  1,490.00     1,490.00                   JS980028
                     Mon Princeton 17"                      1          1172162285    435.00       435.00       1,925.00
                     Mon Princeton 17"                      2                        135.00       270.00                   JS980028
                     Daynapot Adapter                       5                         61.00       305.00         575.00

<CAPTION>
--------------------------------------------------------------------------------------------------------------
Equip Location       3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
                     Exton, PA  19341
--------------------------------------------------------------------------------------------------------------
Supplier             Description                                 Invoice     Invoice         PD          Ck
                                                                 No.         Date          CK #      Amount
==============================================================================================================
<S>                  <C>                                         <C>        <C>          <C>       <C>
LF Systems           Stainless Steel Table w/Mer Top             5851        9/19/97     cc7421     $1,129.00
==============================================================================================================
Mac Warehouse        32MB 168 PIN EDO DIMM                       A7012370    9/16/97     cc7423    $16,815.55
                     32 MB 168 PIN EDO DIMM
                     Daynaport E/PCI-T Ethernet Card
                     Power MAC 4400/200 32MB/2GB                 A7019854    9/16/97          "
                     Mon Apple Multscan 1SAV 15"
                     Mon Poweruser 17                            A7117534    9/17/97          "
                                                                             9/23/97          "
                     Supermac C600E/200                          A738334
                     Supermac C600E/200                          A7383334    9/23/97          "
                     MT0903 MON Sony Trinitron Multiscan         A7366438    9/23/97          "
                     MEM PNY 32MB                                A72758378   9/22/97          "
                     Etherlink 111
                     Carrying Case Notepac - Black
                     Portable Printer/Scanner
                     Lap Pro 440CDX                              A7287345    9/22/97          "
                                                                             10/9/97     cc7538     $5,680.50
                     CPU Presario 4824 P2/233                    A8069577
                     MON Sony 200SF 17"
                     CPU Compac Deskpro 2000                     A8385890   10/16/97     cc7645     $4,641.40
                     Power Base 240MH Tower                      A8983462   10/30/97          "
                     Mon Poweruser 17
                     Mon Princeton 17"                           B0366369   11/17/97     cc7746     $8,153.15
                     Power Base 240MHX Tower                     B0377168   11/17/97          "
                     Starmax 300MT 603E                          B1252782    12/9/97     cc7910    $19,147.80
                     Mon Princeton 17"
                     Superstack II Switch 3000                   B1233253    12/9/97          "
                     Superstack II 1000 Baxe TX
                     FE104 4 port 100 Base TX Hub w/uplink
                     Surgestation Pro 8
                     Mon Princeton 17"                           B1369743    12/11/97         "
                     Bundle HP Laserjet Powerprint
                     Powerbook 2400C/180                         B136855     12/11/97         "
                     Starmax 300MT                               B1394055    12/12/97         "
                     Bundle HP Laserjet Powerprint               B1597533    12/17/97         "
                     Starmax 5500MT                              B1768522    12/22/97    cc8037     $5,829.85
                     Starmax 5500MT                              B1828326    12/23/97         "

                     Shipping
                     Power Mac 4400/200 32MB                     2146488       1/7/98    cc8164    $16,129.30
                     Mon Princeton 17"
                     Mon Princeton 17"                           2141414       1/7/98         "
                     Daynapot Adapter
</TABLE>

                                      19
<PAGE>

                                    EXHIBIT A
                     EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
                    3-Dimensional Pharmaceuticals, Inc.
                    665 Stockton Drive, Suite 104
Equip Location      Exton, PA  19341
-----------------------------------------------------------------------------------------------------------------------------------
                                                                                                Extended
Supplier            Description                             Qty        Serial No.  Price          Price       Sub-Total    PO No.
-----------------------------------------------------------------------------------------------------------------------------------
<S>                 <C>                                     <C>      <C>           <C>          <C>           <C>          <C>
                                                                      SXB7460YX9G
                    Power Mac 4400/200 32MB                  1                  G  1,490.00     1,490.00       1,490.00    JS980028
                    Mon Princeton 17"                        1         1172162295    435.00       435.00         435.00    JS980028
                                                                      SXB7460W69G
                    Power Mac 440/200 32MB                   1                  g  1,490.00     1,490.00                   JS980029
                    Mon Princeton 17"                        1         1172162297    435.00       435.00       1,925.00
                    64MB 168 PIN EDO DIMM                    1                       135.00       135.00         135.00    Js980029
                    Powerbook 3400C/180 16 MB                1       SCK7062377ZQ  3,050.00     3,050.00       3,050.00    JS980062
                    64MB Memory Moldule for Powerbook 3400   1                       298.00       298.00                   JS980062
                    VST Powerbook 3400 Lithium 10N           3                       130.00       390.00
                    Battery
                    Charger F/Powerbook                      2                       140.00       280.00         968.00    JS980062
                    Power Mac 4400/200 32MB                  2       SXB7461N69Gg  1,490.00     2,980.00                   JS980116
                                                                     SXB74614D9GG
                    Mon Princeton 17" Monitor                1         1172162324    435.00       435.00
                    Mon Sony 200GS 17"                       1        So180197701    640.00       640.00       4,055.00
                    64 MB 168 PIN EDO DIMM                   2                       135.00       270.00         270.00    Js980116
                    Mon Princeton 17"                        1         1172162283    435.00       435.00         435.00    JS980188
                                                                      SBX7461NP9G
                    Power Mac 4400/200                       1                  G  1,490.00     1,490.00       1,490.00    JS980188
                    Daynaport Adapter                        1                        61.00        61.00                   JS980188
                    64 MB 168 PIN EDO DIMM                   1                       135.00       135.00         196.00
                    PRN HP Laser Jet                         1                       125.00     1,425.00                   JS980239
                    Shipping                                                                       19.95       1,444.95
                                                                      SXB7460YR9G
                    Power Mac 4400/200                       1                  G  1,490.00     1,490.00                   JS980312
                    Mon Princeton 17"                        1         1172162375    435.00       435.00       1,925.00
                                                                      SXB74014V9W
                    Power Mac 4400/200                       1                  7  1,285.00     1,285.00       1,285.00    Js980495
                    Mon Puser 17"                            1                       369.00       369.00         369.00    JS980495
                    64MB 168 PIN EDO DIMM                    1                       160.00       160.00                   JS980495
                    Etherx PCI 10/100 Card                   1                        43.00        43.00         203.00
                    Power Mac 6500/250 32MB                  1                     1,398.00     1,398.00                   JS980496
                    Mon Puser 17"                            1                       369.00       369.00       1,767.00
                    Etherx PCI 10/100 Card                   1                        43.00        43.00                   JS980496
                    64 MB 168 PIN EDO DIMM                   1                       160.00       160.00         203.00
                                                                      SXB7460YY9G
                    Power Mac 4400/200 32MG/2GB1             1                  g  1,525.00     1,525.00       1,525.00    JS980497
                    Mon Puser 17"                            1                       369.00       369.00         369.00    JS980497
                    64 MB 168 PIN EDO DIMM                   1                       160.00       160.00                   JS980497
                    Etherx PCI 10/100 Card                   1                        43.00        43.00
                    Zip Drive 100MB SCSI                     1                       130.00       130.00         333.00
                    In Focus Litepro 730                     1        IS2C8525406  8,700.00     8,700.00          8,700    JS980503
                    Power Mac 6500/250 32MB                  1       SXB7460GEAWM  1,398.00     1,398.00                   JS980573

<CAPTION>
-----------------------------------------------------------------------------------------------------------
Equip Location      3-Dimensional Pharmaceuticals, Inc.
                    665 Stockton Drive, Suite 104
                    Exton, PA  19341
-----------------------------------------------------------------------------------------------------------
Supplier            Description                                 Invoice     Invoice         PD         Ck
                                                                No.         Date          CK #     Amount
-----------------------------------------------------------------------------------------------------------
<S>                 <C>                                         <C>         <C>         <C>      <C>
                    Power Mac 4400/200 32MB                     B2307379    1/12/98          "
                    Mon Princeton 17"                           B2305951    1/12/98          "

                    Power Mac 440/200 32MB                      B2146645    1/7/98           "
                    Mon Princeton 17"
                    64MB 168 PIN EDO DIMM                       B2148880    1/7/98           "
                    Powerbook 3400C/180 16 MB                   B2215531    1/8/98           "
                    64MB Memory Moldule for Powerbook 3400      2220291     1/8/98           "
                    VST Powerbook 3400 Lithium 10N
                    Battery
                    Charger F/Powerbook                         B2220291    1/8/98
                    Power Mac 4400/200 32MB                     B2542090    1/16/98     cc8204   $10,498.05

                    Mon Princeton 17" Monitor
                    Mon Sony 200GS 17"
                    64 MB 168 PIN EDO DIMM                      B2530228    1/16/98          "
                    Mon Princeton 17"                           B2679728    1/20/98          "

                    Power Mac 4400/200                          B2868446    1/23/98          "
                    Daynaport Adapter                           B2733954    1/21/98          "
                    64 MB 168 PIN EDO DIMM
                    PRN HP Laser Jet                            B3071305    1/28/98          "
                    Shipping

                    Power Mac 4400/200                          B3366820    2/4/98      cc8289   $14,865.75
                    Mon Princeton 17"

                    Power Mac 4400/200                          B4048351    2/20/98          "
                    Mon Puser 17"                               B4052114    2/20/98          "
                    64MB 168 PIN EDO DIMM                       B4038030    2/20/98          "
                    Etherx PCI 10/100 Card
                    Power Mac 6500/250 32MB                     B4055513    2/20/98          "
                    Mon Puser 17"
                    Etherx PCI 10/100 Card                      B4046256    2/20/98
                    64 MB 168 PIN EDO DIMM

                    Power Mac 4400/200 32MG/2GB1                B4045654    2/20/98          "
                    Mon Puser 17"                               B4052486    2/20/98
                    64 MB 168 PIN EDO DIMM                      B40384651   2/20/98          :
                    Etherx PCI 10/100 Card
                    Zip Drive 100MB SCSI
                    In Focus Litepro 730                        B45131917   3/4/98      cc8559   $19,591.25
                    Power Mac 6500/250 32MB                     B4521472    3/4/98           "
</TABLE>

                                      20
<PAGE>

                                    EXHIBIT A
                     EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
Equip Location    3-Dimensional Pharmaceuticals, Inc.
                  665 Stockton Drive, Suite 104
                  Exton, PA  19341
-----------------------------------------------------------------------------------------------------------------------------------
                                                                                                 Extended
Supplier          Description                                Qty        Serial No.  Price          Price       Sub-Total    PO No.
-----------------------------------------------------------------------------------------------------------------------------------
<S>               <C>                                        <C>     <C>           <C>         <C>            <C>          <C>
                  Mon Puser 17"                              1                       369.00       369.00       1,767.00
                  64 MB 168 PIN EDO DIMM                     1                       160.00       160.00         160.00    JS980573

                  Power Mac 6500/2250 32MB                   1       SXB7453VMAWM  1,398.00    $1,398.00                   JS980649
                  Mon Puser 17"                              1                       369.00       369.00       1,767.00
                  64 MB 168 PIN EDO DIMM                     1                       160.00       160.00                   JS980649
                  Etherx PCI 10/100 Card                     1                        43.00        43.00         203.00
                  Power Mac G3/266MHZ                        1       SXB807419AZ3  2,415.00     2,415.00      24,415.00    JS980650
                  Mon Puser 17                               1                       369.00       369.00         369.00    JS980650
                  Mem Puser 128MB Sdram                      1                       375.00       375.00                   JS980650
                  Etherx PCI 10/100 Card                     1                        43.00        43.00
                  Shipping & Handling                                                              24.45         442.45
                  Accessbuilder 4000 8 Prot Asyne Module     1                     1,500.00     1,500.00       1,500.00    JS980655
                  Accessbuilder 4200 Ethernet Base System    1                     1,675.00     1,675.00       1,675.00    JS980655
                  Power Mac 6500/225 32MB                    1       SXB74978Z9CL  1,215.00     1,215.00                   JS980731
                  Mon Puser 17"                              1                       368.00       368.00       1,583.00
                  Superstack II Switch Gigabit Enet SX
                  Module                                     1                     1,970.00     1,970.00       1,970.00    JS980735
                  Superstack II Switch                       1                     2,400.00     2,400.00                   JS980735
                  Superstack II Switch Gigabit Enet SX
                  Module                                     1                     1,920.00     1,920.00
                  Shipping & Handling                                                              21.20       4,341.20
                  Superstack II Switch 3000                  1                     1,500.00     1,500.00                   JS980735
                  Shipping & Handling                                                              17.45       1,517.45

                  Power MAC G3/233/MHZ                       1        SXB8115FRBB  1,598.00     1,598.00       1,598.00    JS980899
                  Mon Puser 17"                              1                       369.00       369.00         369.00    JS980899
                  CPU Compac Deskpro 2000                    1      S6740BK82P043  1,109.00     1,109.00                   JS980945
                  Shipping  & Handling                                                             17.85       1,126.85
                  Mon Hitachi MC7515 19"                     1          V8B000581    885.00       885.00         885.00    JS980988

                  Power Mac 4400/200                         1       SXB7461XF9GG  1,175.00     1,175.00       1,175.00    JS980988
                  Netserver/8 Plus Enter Lan w/ integrated   1                     2,829.00     2,829.00                   JS980986
                  Shipping & Handling                                                             $15.15       2,844.15
                  Supermac C600VPC/240/w/Scanner             1           V8800592  1,249.00     1,249.00                   JS981211
                  Mon Hitachi                                1                       885.00       885.00       2,134.00
                  64 MB 168 PIN EDO DIMM                     1                       105.00       105.00                   JS981211
                  Etherx PCI 10/100 Card                     1                        48.00        48.00         153.00

                  Power Mac G3/200MHZ                        1       SXA81715CD6M  3,185.00     3,185.00       3,185.00    JS981212
                  Mem Puser 128 MB Sdram F/Power Mac G-3     1                       265.00       265.00                   JS981212
                  Etherx PCI 10/100 Card                     1                        48.00        48.00         313.00
                  Mon Puser 17"                              1                       319.00       319.00         319.00    JS981257
                  64MB 168 PIN EDO DMM                       1                       105.00       105.00                   JS981257
                  Etherx PCI 10/100 Card                     1                        48.00        48.00         153.00

<CAPTION>
--------------------------------------------------------------------------------------------------------------------------------
Equip Location    3-Dimensional Pharmaceuticals, Inc.
                  665 Stockton Drive, Suite 104
                  Exton, PA  19341
-----------------------------------------------------------------------------------------------------------------
                                                                            Invoice         PD         Ck
Supplier          Description                                 Invoice No.   Date          CK #     Amount
-----------------------------------------------------------------------------------------------------------------
<S>               <C>                                         <C>          <C>         <C>        <C>
                  Mon Puser 17"
                  64 MB 168 PIN EDO DIMM                      B4496022     3/4/98           "

                  Power Mac 6500/2250 32MB                    B4755104     3/10/98          "
                  Mon Puser 17"
                  64 MB 168 PIN EDO DIMM                      B4780078     3/10/98          "
                  Etherx PCI 10/100 Card
                  Power Mac G3/266MHZ                         B4759536     3-10-98          "
                  Mon Puser 17                                B4765418     3-10-98          "
                  Mem Puser 128MB Sdram                       B4757316     3/10/98
                  Etherx PCI 10/100 Card
                  Shipping & Handling
                  Accessbuilder 4000 8 Prot Asyne
                  Module                                      B5103270     3/18/98     cc8596     $29,291.03
                  Accessbuilder 4200 Ethernet Base System     B5242110     3/20/98          "
                  Power Mac 6500/225 32MB                     B5202031     3/19/98          "
                  Mon Puser 17"
                  Superstack II Switch Gigabit Enet SX
                  Module                                      B5203138     3/19/98          :
                  Superstack II Switch                        B6506679     4/17/98
                  Superstack II Switch Gigabit Enet SX
                  Module
                  Shipping & Handling
                  Superstack II Switch 3000                   B6548481     4/20/98          "
                  Shipping & Handling
                  Power MAC G3/233/MHZ                        B6088207     4/7/98
                  Mon Puser 17"                               B6091102     4/798            "
                  CPU Compac Deskpro 2000                     B6214779     4/9/98           "
                  Shipping  & Handling
                  Mon Hitachi MC7515 19"                      B6405971     4/30/98
                  Power Mac 4400/200                          B6425805     4/15/98          "
                  Netserver/8 Plus Enter Lan w/ integrated    B7458102     5/12/98          "
                  Shipping & Handling
                  Supermac C600VPC/240/w/Scanner              B7256076     5/6/98           "
                  Mon Hitachi
                  64 MB 168 PIN EDO DIMM                      B7220676     5/6/98
                  Etherx PCI 10/100 Card
                  Power Mac G3/200MHZ                         B7252653     5/6/98
                  Mem Puser 128 MB Sdram F/Power Mac G-3      B7236243     5/6/98
                  Etherx PCI 10/100 Card
                  Mon Puser 17"                               B7524226     5/13/98
                  64MB 168 PIN EDO DMM                        B7506876     5/13/98
                  Etherx PCI 10/100 Card
</TABLE>

                                      21
<PAGE>

                                   EXHIBIT A
                    EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

<TABLE>
<CAPTION>
--------------------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
--------------------------------------------------------------------------------------------------------------------------------
                                                                                              Extended
Supplier             Description                            Qty    Serial No.      Price       Price        Sub-Total
--------------------------------------------------------------------------------------------------------------------------------
<S>                  <C>                                    <C>    <C>           <C>          <C>           <C>
                     Supermac C600 VPC/240 w/Scanner        1                    1,249.00     1,249.00       1,249.00
                     Supermax C600VPC/240 w/Scanner         1                    1,249.00     1,249.00       1,240.00
                     64M13 168 PIN EDO DIMM                                        150.00       150.00
                     Etherx PCI 10/100 Card                 1                       48.00        48.00         153.00
                     Mon Puser 17"                          1                      319.00       319.00         319.00
                     Powerbook 1400c                        1                    1,870.00     1,870.00       1,870.00

                     24MB Memory Module for Powerbook 1400  1                       88.00        88.00
                     Internal Zip Drive                     1                      209.00       209.00
                     336 PC Card Ethernet Modem             1                      278.00       278.00
                     Shipping & Handling                                                         13.80         588.00
                     Power MAC G3/23/MHZ                    1     Sxb8110phhbsq  1,880.00     1,880.00       1,880.00
                     Mon Hitachi 17"                        1            T7K001    549.00       549.00         549.00

                     Mem Puser 64MB Sdram F/power Mac G3    1                      135.00       135.00
                     Etherx PCI 10/100 Card                 1                       48.00        48.00         183.00
Matix Tech.          Platemate 4 Position                   1      I-00003224   40,900.00
                     Tip Wash Station                       1                    2,600.00     2,600.00
                     Adapter                                1                      335.00       335.00
                     Tip magazine 96/284, 25UL              1                      495.00       495.00
                     Shipping & Handling                                                        192.82      44,522.82
MICRON               Milennia XKU 300                       1                    4,197.00     4,197.00
Dimitris Agra.       Shipping & Handling                                                         65.00
Equip Location       3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
--------------------------------------------------------------------------------------------------------------------------------
                     Exton, PA  19341
================================================================================================================================
                                                                                              Extended
Supplier             Description                            Qty    Serial No.      Price       Price        Sub-Total
--------------------------------------------------------------------------------------------------------------------------------
                     Taxes                                                                     255.72        4,517.72
--------------------------------------------------------------------------------------------------------------------------------
Micron               Sys ATO Model BOM                      1    1216147-0001  $3,922.00    $3,922.00
--------------------------------------------------------------------------------------------------------------------------------
                     Sys ATO Model BOM                      1    1216146-0001  $3,471.00    $,3471.00        7,393.00
--------------------------------------------------------------------------------------------------------------------------------
                     Micron Compute ATO Model               1                  $3,849.00    $3,849.00
--------------------------------------------------------------------------------------------------------------------------------
                     Shipping & Handling                                                       $99.00        3,948.00
--------------------------------------------------------------------------------------------------------------------------------
                     ATO Computer Model BOM                 1    1128302-0001  $2,686.00    $2,686.00
--------------------------------------------------------------------------------------------------------------------------------
                     Shipping & Handling                                                       $99.00        2,785.00
================================================================================================================================
Molecular            RoMomax Instrument Refurb.             2         RB00532  $7,388.00   $14,776.00
Devices                                                               RB00533                   $0.00
                     Shipping & Handling                                                      $200.00       14,976.00
Molecular            RoMomax Instrument Refurb.             1         RB00541  $7,388.00    $7,388.00       $7,388.00
================================================================================================================================
New Brunswick        Innova 4080 120V                       1      8901312640  $5,200.00    $5,200.00
                     Sticky Mat Roll, Gr                    1                    $264.00      $264.00
                     Freight                                                                   $50.15       $5,514.15
                     Innova 4080 120V                       1       890312648  $5,200.00    $5,200.00
<CAPTION>
-------------------------------------------------------------------------------------------------------------------------------
                     3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
Equip Location       Exton, PA  19341
-------------------------------------------------------------------------------------------------------------------------------
                                                                           Invoice     Invoice     PD        Ck
Supplier             Description                              PO No.       No.         Date        CK #      Amount
-------------------------------------------------------------------------------------------------------------------------------
<S>                  <C>                                      <C>          <C>         <C>         <C>       <C>
                     Supermac C600 VPC/240 w/Scanner          JS981257     B7509052    5/13/98
                     Supermax C600VPC/240 w/Scanner           JS981258     B7509060    5/13/98
                     64M13 168 PIN EDO DIMM                   JS981258     B7513179    5/13/98
                     Etherx PCI 10/100 Card
                     Mon Puser 17"                            JS981258     B7540222    5/13/98
                     Powerbook 1400c                          Js981298     B7528276    5/13/98

                     24MB Memory Module for Powerbook 1400    JS981298     B7498181    5/13/98
                     Internal Zip Drive
                     336 PC Card Ethernet Modem
                     Shipping & Handling
                     Power MAC G3/23/MHZ                      JS981299     B7510142    5/13/98
                     Mon Hitachi 17"                          Js981299     B7523707    5/13/98

                     Mem Puser 64MB Sdram F/power Mac G3      JS981299     B7504921    5/13/98
                     Etherx PCI 10/100 Card                   JS981299     B7504921    5/13/98
Matix Tech.          Platemate 4 Position                     JS980687     71489       3/16/98     cc8697    $48,868.34
                     Tip Wash Station
                     Adapter
                     Tip magazine 96/284, 25UL
                     Shipping & Handling
MICRON               Milennia XKU 300                         DA971700                             Cc7589    $5,521.57
Dimitris Agra.       Shipping & Handling
Equip Location       3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
-------------------------------------------------------------------------------------------------------------------------------
                     Exton, PA  19341
===============================================================================================================================
                                                                           Invoice     Invoice     PD        Ck
Supplier             Description                              PO No.       No.         Date        CK #      Amount
-------------------------------------------------------------------------------------------------------------------------------
                     Taxes
-------------------------------------------------------------------------------------------------------------------------------
Micron               Sys ATO Model BOM                        JS980983     1863973     5/8/98
-------------------------------------------------------------------------------------------------------------------------------
                     Sys ATO Model BOM
-------------------------------------------------------------------------------------------------------------------------------
                     Micron Compute ATO Model                 JK980095     1606148     1/17/98     cc8345    $10,102.00
-------------------------------------------------------------------------------------------------------------------------------
                     Shipping & Handling
-------------------------------------------------------------------------------------------------------------------------------
                     ATO Computer Model BOM                   JS980211     1636289     1/30/98
-------------------------------------------------------------------------------------------------------------------------------
                     Shipping & Handling
-------------------------------------------------------------------------------------------------------------------------------
Molecular            RoMomax Instrument Refurb.               JK980686     134071      3/20/98     cc8704    $23,889.00
Devices
                     Shipping & Handling
Molecular            RoMomax Instrument Refurb.               JK980686     134061      4/6/98      cc8704    $23,889.00
-------------------------------------------------------------------------------------------------------------------------------
New Brunswick        Innova 4080 120V                         ZW980278     204135      3/17/98     cc8759    $5,514.15
                     Sticky Mat Roll, Gr
                     Freight
                     Innova 4080 120V                         ZW981045     205470      5/1/98
</TABLE>

                                      22
<PAGE>

                                   EXHIBIT A
                    EQUIPMENT SCHEDULE 3-DIMENSIONAL PHARM

<TABLE>
<CAPTION>
----------------------------------------------------------------------------------------------------------------------------------
Equip Location       3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
                     Exton, PA  19341
----------------------------------------------------------------------------------------------------------------------------------
                                                                                                Extended
Supplier             Description                           Qty      Serial No.       Price       Price       Sub-Total     PO No.
----------------------------------------------------------------------------------------------------------------------------------
                     Sticky Mat Roll, GR                    1                     $   264.00   $   264.00
                     Freight                                                                   $    64.04      5,528.04
----------------------------------------------------------------------------------------------------------------------------------
Nonius               Fixed Oil Cooled Cathode               1                     $ 7,629.60     7,629.60      7,629.60   MM980214
----------------------------------------------------------------------------------------------------------------------------------
RCh                  Raid Rack Mount Conversion/expansion   1                     $17,066.00   $17,066.00                 JS980126
                     8-4404
                     Shipping & Handling                                                       $   486.55     17,552.55
                     DLT7700, 15 Cartridge racount mini     1                     $20,836.00   $20,836.00                 JS980678
                     library
                     9.1 GB Ultra Wide Option Disk          1                     $ 1,351.00   $ 1,351.00
                     Bracket                                1                     $   210.00   $   210.00
                     Shipping & Handling                                                       $   164.00     22,561.00
----------------------------------------------------------------------------------------------------------------------------------
Robbins              1_____-96 Flexchem 1 ML Tall 115V      1                     $22,500.00   $22,500.00                 ZW980778
                     Freight                                                                   $    81.90     22,581.90
----------------------------------------------------------------------------------------------------------------------------------
Savant               Speedvac w/bleeder valve 115V          1                     $ 1,890.00   $ 1,890.00                 JR980778
                     Freight                                                                   $    17.55      1,907.55
                     Rotor F/Marsh Plates w/4 Carriers     1                     $ 1,260.00   $ 1,260.00                 ZW980181
                     Freight                                                                   $     9.30      1,269.30
----------------------------------------------------------------------------------------------------------------------------------
Techne, Inc.         Genius 120V 384 Well                   2                     $ 4,152.00   $ 8,304.00    $ 8,304.00   JK980685
----------------------------------------------------------------------------------------------------------------------------------
-----------------
----Vacuubrand       Model MZ2C Diaphragm Pump              1      20523904-97    $ 1,965.00   $ 1,965.00                 JJ981261
                     Freight                                                      $    15.45     1,980.45
Equip Location       3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
                     Exton, PA
                                                                                                Extended
Supplier             Description                            Qty     Serial No.    Price           Price        Sub-Total   PO No.

Water Mgnt           Comro-800P Reverse Osmosis Unit        1                     $ 2,408.54   $ 2,408.54                 BW980064
                     Pressure Storage Tank                  2                     $   829.92   $ 1,659.84      4,068.38

                     TOTAL                                                                                   699,733.78
----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
------------------------------------------------------------------------------------------------------------
Equip Location       3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
                     Exton, PA  19341
------------------------------------------------------------------------------------------------------------
                                                              Invoice       Invoice     PD        Ck
Supplier             Description                              No.           Date        CK #      Amount
------------------------------------------------------------------------------------------------------------
                     Sticky Mat Roll, GR
                     Freight
------------------------------------------------------------------------------------------------------------
<S>                  <C>                                      <C>          <C>          <C>       <C>
Nonius               Fixed Oil Cooled Cathode                      73977    3/18/98     cc8709    $ 9,786.88
------------------------------------------------------------------------------------------------------------
RCh                  Raid Rack Mount Conversion/expansion          82538
                     8-4404                                                 1/20/98     cc8140    $17,552.55
                     Shipping & Handling
                     DLT7700, 15 Cartridge racount mini            82603
                     library                                                 4/3/98     cc8729    $22,561.00
                     9.1 GB Ultra Wide Option Disk
                     Bracket
                     Shipping & Handling
------------------------------------------------------------------------------------------------------------
Robbins              1_____-96 Flexchem 1 ML Tall 115V          10087744    4/30/98
                     Freight
------------------------------------------------------------------------------------------------------------
Savant               Speedvac w/bleeder valve 115V                145626   10/31/97     cc7754    $13,057.55
                     Freight
                     Rotor F/Marsh Plates w/4 Carriers           148963     2/5/98     cc8317    $ 1,066.13
                     Freight
------------------------------------------------------------------------------------------------------------
Techne, Inc.         Genius 120V 384 Well                         239669    3/13/98     cc8588    $ 8,304.00
------------------------------------------------------------------------------------------------------------
-----------------                                                    558    5/14/98
----Vacuubrand       Model MZ2C Diaphragm Pump
                     Freight
Equip Location       3-Dimensional Pharmaceuticals, Inc.
                     665 Stockton Drive, Suite 104
                     Exton, PA
                                                                             Invoice     PD       Ck
Supplier             Description                                 Invoice     Date        Ck #     Amount
                                                                 No.
Water Mgnt           Comro-800P Reverse Osmosis Unit            802063.1    2/1/98      cc8483    $ 4,519.97
                     Pressure Storage Tank

                     TOTAL
------------------------------------------------------------------------------------------------------------
</TABLE>

                                      23
<PAGE>

                           PAYMENT ADJUSTMENT RIDER

     Rider to Schedule No. 01 dated June 18, 1998 to Master Loan and Security
                           --       -------------
Agreement No. 7110 dated June 18, 1998 (THE "CONTRACT") Between 3-Dimensional
              ----       -------------                          -------------
Pharmaceuticals, Inc. as Borrower (THE "OBLIGOR") AND PHOENIXCOR, INC. as Lender
---------------------
("P.C.")

     19.  Purpose. This Rider sets forth the terms of adjustment to the payments
          -------
set forth in the Contract.

     20.  Definitions. The following terms shall have the following meanings
          -----------
herein:

          (a)  "Adjustment Date" shall mean the date P.C. disburses any portion
of the proceeds of the Contract.

          (b)  "Final T-Note Average" shall mean the average of the yields on
U.S. Treasury Notes maturing in 4 years, as published by the Dow Jones Telerate
Access Service, Page 19901, for the close of business on each business day of
the two full calendar weeks immediately preceding the week containing the
Adjustment Date.

          (c)  "Preliminary Payments" shall mean the payments set forth in the
Contract, consisting of ($40,671.13 due upon execution followed by) 46
consecutive (monthly or quarterly) payments in the amount of $40,671.13
commencing 30 days after the adjustment Date, followed by one monthly payment of
$164,820.60.

          (d)  "Preliminary T-Note Average" shall mean 5.41%.
                                                       -----

     21.  Adjustment of Payments. The Preliminary Payments were calculated based
          ----------------------
on a spread over the Preliminary T-Note Average. If the Adjustment Date occurs
after June 17, 1998 and the Final T-Note Average exceeds the Preliminary T-Note
Average, then the Preliminary Payments shall be revised. For each increase or
decrease of one (1) basis point (i.e., 1/100 of 1%) in the Final T-Note Average
above the Preliminary T-Note Average, the Preliminary Payments shall be revised
as follows (complete below as applicable):

 .    The $40,671.13 payment due upon execution shall remain unchanged.
         ----------

 .    Each of the 46 payments in the amount of $40,671.13 shall increase or
                 --                           ----------
decrease by $8.24.

Immediately after the determination of the revised payments due under the
Contract, Obligor shall, at the request of P.C., execute an acknowledgement
reflecting the revised payment schedule and, if requested by P.C., a Replacement
Contract containing the agreed to payments, but the failure of P.C. to make such
a request or the failure of Obligor to execute the acknowledgement or
Replacement Contract shall in no way diminish Obligor's obligations hereunder.

     22.  P.C.'s Requirements. The commencement of the Contract is subject to
satisfaction of all documentation and credit requirements of P.C. If such
requirements are not satisfied by the Adjustment Date, then at P.C.'s option,
the Adjustment Date shall be the date when such requirements are satisfied.

The calculation of the Contract payments under this Rider will supersede any
prior proposal or quotation.

     IN WITNESS WHEREOF, the parties have executed this Rider simultaneously
with the Contract.

PHOENIXCOR, INC.                        3-Dimensional Pharmaceuticals, Inc.

By:  /s/ Thomas J. Williams             By:  /s/ Scott Horvitz
     ____________________________            _______________________________

TITLE: Executive Vice President         TITLE: Vice President, Finance
       __________________________              _____________________________

                                      24
<PAGE>

                SCHEDULE TO MASTER LOAN AND SECURITY AGREEMENT

MASTER LOAN AND SECURITY AGREEMENT NO.7110             DATED: June 18, 1998
                                      ----                    -------------
SCHEDULE NO.02                                         DATED: September 25, 1998
            --                                                ------------------
--------------------------------------------------------------------------------
LENDER:   PHOENIXCOR, INC.      BORROWER:   3-Dimensional Pharmaceuticals, Inc.
          65 WATER STREET                   Eagleview Corporate Center,
          SOUTH NORWALK, CT 06854           665 Stockton Drive, Suite 104
                                            Exton, PA 19341

Equipment Location (if other than above address of Borrower): n/a
                                                              ---

     Lender and Borrower have entered into a Master Loan and Security Agreement
No. 7110 dated June 18, 1998 (the "Master Loan Agreement") which is incorporated
    ----       -------------
herein and this is a Schedule to the Master Loan Agreement. All words and terms
used herein and not specifically defined herein shall have the same meanings as
set forth in the Master Loan Agreement.

     1.   THE LOAN AND LOAN REPAYMENT. As requested by Borrower and pursuant to
the Master Loan Agreement, Lender agrees to lend to Borrower the sum of one
                                                                        ---
million two hundred twenty-three thousand eight hundred eighty-three dollars and
--------------------------------------------------------------------------------
ninety-six cents. Borrower agrees to repay the Loan in successive installments
----------------
(which installment payments are inclusive of interest) as set forth in the
following Schedule:

                                   SCHEDULE
--------------------------------------------------------------------------------
Advance Payment Amount:                                  $30,200.56
Number of Installments (Exclusive of Advance Payment):   46
Payment Period:                                           X Monthly ___Quarterly
                                                         ---
Periodic Installment Payment Amount Per Period:          $30,200.56;
         Followed by One Monthly Installment Payment of  $122,388.40
--------------------------------------------------------------------------------
Commencement Date:  September 29, 1998                   Security Deposit (if
Special Provisions: (if any): none                       any): none

     2.   SECURITY. As security for Borrower's obligations under this Schedule
and the obligations contained in the Master Loan Agreement, the Borrower gives
and grants to the Lender a security interest in the Equipment described in the
attached Exhibit A.

     3.   LOAN DISBURSEMENT. Borrower hereby authorizes Lender to disburse the
Loan proceeds advanced pursuant to this Schedule as follows:

     $1,223,883.96         To: 3-Dimensional Pharmaceuticals, Inc.
     -------------             -----------------------------------
     $1,223,883.96         TOTAL PROCEEDS
     -------------

By execution hereof, the signer certifies that he/she is a duly authorized
officer, partner or proprietor of Borrower and that he/she had read, accepted
and duly executed this Schedule to the Master Loan Agreement on behalf of
Borrower.

                                 3-Dimensional Pharmaceuticals, Inc., (Borrower)
                                 -------------------------------------

                                 BY:
                                     ___________________________________________

                                 _______________________________________________
                                 Print Name and Title

ACCEPTED AT LENDER'S OFFICE AT
SOUTH NORWALK, CONNECTICUT

PHOENIXCOR, INC. (Lender)

BY:
    _______________________

Print Name and Title

                                      25
<PAGE>

                                   EXHIBIT A

     The following description of property supplements, and is part, Schedule
No. 02 dated September 25, 1996 to Master Loan and Security Agreement No. 7110
dated June 18, 1998 between the undersigned Borrower and Phoenixcor, Inc. and
may be attached to said Loan Schedule and any related UCC Financing Statements,
Acceptance or Delivery Certificate or other document describing the property:

                   See Attached Exhibit A Equipment Schedule

All property listed above complete with any and all attachments, accessions,
additions, replacements, improvements, modifications and substitutions thereto
and therefor and all proceeds including insurance proceeds thereof and
therefrom.

PHOENIXCOR, INC.                          3-Dimensional Pharmaceuticals, Inc.
----------------                          -----------------------------------
(Lender)                                  (Borrower)

BY: /s/ Thomas J. Williams                By:  /s/ Scott Horvitz
    ______________________                    _________________________________
TITLE: Executive Vice President           TITLE: Vice President, Finance
       ________________________                  ______________________________

                                      26
<PAGE>

<TABLE>
<CAPTION>
3-Dimensional Pharmaceutical, Inc.
Eagleview Corporate Center                                     3-Dimensional Pharmaceuticals, Inc.                        Exhibit A
665 Stockton Drive, Suite 104                                           Equipment Financing                         Schedule No. 02
Exton, PA  19341
-----------------------------------------------------------------------------------------------------------------------------------
QTY                EQUPIMENT                REQ.   PURCHASE     INVOICE        CATALOG          SERIAL         SUPPLIER/VENDOR
                 DESCRIPTION                       ORDER #        NO.            NO.             NO.
-----------------------------------------------------------------------------------------------------------------------------------
<S>   <C>                                   <C>    <C>          <C>           <C>             <C>            <C>
 2    PC Computer System - Millennia        KJ     981356       1893896              Sys1                    Micron Electronics,
      400                                                                                                    Inc.
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              JK     981356       1893896
-----------------------------------------------------------------------------------------------------------------------------------
 1    CPU Compaq Deskpro 2000 P/233MMX      JS     981369       B8647117           CP5250     S6808BNT2P474  MicroWarehouse
-----------------------------------------------------------------------------------------------------------------------------------
 3    17' Sony Monitor 200 PS               DA     981480       B8200503           MT2134       SO170134012  MacWarehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              DA     981480
-----------------------------------------------------------------------------------------------------------------------------------
                                                                                                 0010017376
-----------------------------------------------------------------------------------------------------------------------------------
 3    GP6-400 System                        DA     981481       31854580          1001495         001001737  Gateway 2000, Inc.
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              DA     981481
-----------------------------------------------------------------------------------------------------------------------------------
 2    17" Power User Monitor                JS     981577                                                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    17" Power User Monitor                JS     981577       B7524226          MON0629                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 2    17" Power User Monitor                JS     981577       B9116443          MON0629                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    17" Power User Monitor                JS     981577       B8900169          MON0629                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    64MB SDRAM Memory                     JS     981577       B8604167          CHP0542                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Power Mac G#/233MHX 32MB RAM          JS     981577       B8584575          CPU0956      SXB8201WJCY3  Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Etherx PCI card                       JS     981577       B8604167          DEC2256                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    17" Power User Monitor                JS     981577       B8584575          MON0629                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Executone Phone System Upgrade        EJ     981582       179169                                       Executone
                                                                                                             Information Systems
-----------------------------------------------------------------------------------------------------------------------------------
 1    Micron Computer - Millenia 400 PC     JM     981717       4001541; YS1, 1271117-001                    Micron Electronics,
                                                                                                             Inc.
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              JM     981717                                                    Micron Electronics,
                                                                                                             Inc.
-----------------------------------------------------------------------------------------------------------------------------------
 1    Discount                              JM     981717                                                    Micron Electronics,
                                                                                                             Inc.
-----------------------------------------------------------------------------------------------------------------------------------
 1    Power Mac G3/233/MHZ                  JS     981834       B9560723           CPU0956     SXA8181JQCY3  Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    17" Power Uwer Monitor                JS     981834       B9560723            MT1514                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    17" Power User Monitor                JS     981834       B9450723            MT1514                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Memory for G3                         JS     981834       B9557620           CHP0542                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              JS     981834                                                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Memory for G3                         JS     981836       B9559485           CHP0542                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Power Mac G3/233MHZ                   JS     981836       B9554056           CPU0956     SXA81825UCY3  Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    17" Power User Monitor                JS     981836       B9554056           MT 1514                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              JS     981836                                                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Memory for G3                         JS     981`837      B9564287           CHP0542                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Power Mac G3/233MHZ                   JS     981837       B9559030           CPU0956     SXAB182NUCY3  Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    17" Power Uwer Monitor                JS     981837       B9559030            MT1514                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              JS     981837                                                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Minolta Copier                        SO     981912       8072006048         1161311     3,111,086.00  Minolta Business
                                                                                    Ep6001                   System, Inc.
-----------------------------------------------------------------------------------------------------------------------------------
 1    Minolta Fax                           SO     981913       9082006049    4266111Fax2500  11,113,839.00  Minolta Business
                                                                                                             Systems, Inc.
-----------------------------------------------------------------------------------------------------------------------------------
 1    Power Book G3/233/MHZ                 JS     982039       CO215327           CPU1162     SCK8250MGD3C  Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Memory for G3 Power Book              JS     982039       CO214387           CHP9822                   Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              JS     982039                                                    Mac Warehouse
-----------------------------------------------------------------------------------------------------------------------------------
 1    Dell PC Pentium II Minitower          GP     982046       171984651         220-0437                   Del Computer
      System                                                                                                 Corporation
-----------------------------------------------------------------------------------------------------------------------------------
 1    Shipping                              GP     982046                                                    Dell Computer
-----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
-----------------------------------------------------------------------------------
                   EQUPIMENT                  EQUIPMENT     EQUIPMENT       PAID -
QTY              DESCRIPTION                 COST - Each       COST        CHECK #
-----------------------------------------------------------------------------------
<S>   <C>                                  <C>            <C>             <C>
 2    PC Computer System - Millennia       4,510.00        9,020.00        9116
      400
-----------------------------------------------------------------------------------
 1    Shipping                               268.00          268.00        9116
-----------------------------------------------------------------------------------
 1    CPU Compaq Deskpro 2000 P/233MMX     1,099.00        1,099.00        9117
-----------------------------------------------------------------------------------
 3    17' Sony Monitor 200 PS                755.00        2,265.00        9111
-----------------------------------------------------------------------------------
 1    Shipping                                55.55           55.55        9111
-----------------------------------------------------------------------------------

-----------------------------------------------------------------------------------
 3    GP6-400 System                       2,886.00        8,658.00        9091
-----------------------------------------------------------------------------------
 1    Shipping                               285.00          285.00        9111
-----------------------------------------------------------------------------------
 2    17" Power User Monitor                (329.95)        (659.90)       9111
-----------------------------------------------------------------------------------
 1    17" Power User Monitor                (290.29)        (290.29)       9111
-----------------------------------------------------------------------------------
 2    17" Power User Monitor                 329.95          659.90        9111
-----------------------------------------------------------------------------------
 1    17" Power User Monitor                 319.00          319.00        9111
-----------------------------------------------------------------------------------
 1    64MB SDRAM Memory                      130.00          130.00        9111
-----------------------------------------------------------------------------------
 1    Power Mac G#/233MHX 32MB RAM         1,598.00        1,598.00        9111
-----------------------------------------------------------------------------------
 1    Etherx PCI card                         48.00           48.00        9111
-----------------------------------------------------------------------------------
 1    17" Power User Monitor                 319.00          319.00        9111
-----------------------------------------------------------------------------------
 1    Executone Phone System Upgrade      42,484.63       42,484.63        9201
-----------------------------------------------------------------------------------
 1    Micron Computer - Millenia 400 PC    4,071.00        4,071.00        9591
-----------------------------------------------------------------------------------
 1    Shipping                               124.00          124.00        9591
-----------------------------------------------------------------------------------
 1    Discount                               (20.00)         (20.00)       9591
-----------------------------------------------------------------------------------
 1    Power Mac G3/233/MHZ                 1,598.00        1,598.00        9728
-----------------------------------------------------------------------------------
 1    17" Power Uwer Monitor                 289.95          289.95        9728
-----------------------------------------------------------------------------------
 1    17" Power User Monitor                  98.00           98.00        9728
-----------------------------------------------------------------------------------
 1    Memory for G3                           98.00           98.00        9728
-----------------------------------------------------------------------------------
 1    Shipping                                26.40           26.40        9728
-----------------------------------------------------------------------------------
 1    Memory for G3                           98.00           98.00        9728
-----------------------------------------------------------------------------------
 1    Power Mac G3/233MHZ                  1,598.00        1,598.00        9728
-----------------------------------------------------------------------------------
 1    17" Power User Monitor                 289.95          289.95        9728
-----------------------------------------------------------------------------------
 1    Shipping                                26.40           26.40        9728
-----------------------------------------------------------------------------------
 1    Memory for G3                           98.00           98.00        9728
-----------------------------------------------------------------------------------
 1    Power Mac G3/233MHZ                  1,598.00        1,598.00        9728
-----------------------------------------------------------------------------------
 1    17" Power Uwer Monitor                 289.95          289.95        9728
-----------------------------------------------------------------------------------
 1    Shipping                                26.40           26.40        9278
-----------------------------------------------------------------------------------
 1    Minolta Copier                      22,458.97       22,458.97        9592
-----------------------------------------------------------------------------------
 1    Minolta Fax                          1,690.70        1,690.70        9592
-----------------------------------------------------------------------------------
 1    Power Book G3/233/MHZ                2,200.00        2,200.00        9728
-----------------------------------------------------------------------------------
 1    Memory for G3 Power Book               198.00          198.00        9728
-----------------------------------------------------------------------------------
 1    Shipping                                 9.90            9.90        9728
-----------------------------------------------------------------------------------
 1    Dell PC Pentium II Minitower         3,075.00        3,075.00        9552
      System
-----------------------------------------------------------------------------------
 1    Shipping                                90.00           90.00        9552
-----------------------------------------------------------------------------------
</TABLE>

                                      27
<PAGE>

<TABLE>
<S>   <C>                                   <C>    <C>          <C>            <C>              <C>            <C>
----------------------------------------------------------------------------------------------------------------------------------
                                                                                                               Corporation
----------------------------------------------------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ 32MB              JS     982209       CO711820            CPU0958                    Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ 32MB              JS     982209       CO707117            CPU0958      SXB824550CY5  Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     Memory for G3                         JS     982209       CO722496            CHP0542                    Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     Memory for G3                         JS     982209       CO712182                                       Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ 32MB              JS     982427       C1490119            CPU0957      SXZ8241TNCY4  Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     64 MB Memory                          JS     982427       C1489889            CHP0429                    Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     17" Daytek Monitor                    JS     982427       C1469428             MT2377     DV9805J100015  Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     Shipping                              JS     982427                                                      Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
1     Shipping                              JS     982427                                                      Mac Warehouse
----------------------------------------------------------------------------------------------------------------------------------
                                                                                                               Office equipment
                                                                                                               and Furniture
----------------------------------------------------------------------------------------------------------------------------------
1     2 Position Thermal Sample Changer     GP     980604       100143202           FL-1012                    Instruments,
                                                                                                               S.A./SPEX
----------------------------------------------------------------------------------------------------------------------------------
1     Robomax Refurbished                   JK     980686       135661           9000-0157R           RB00518  Molecular Devices
                                                                                                               Corporation
----------------------------------------------------------------------------------------------------------------------------------
1     Robomax Refurbished                   JK     980686       135487          9000-0157-R           RB00521  Molecular Devices
                                                                                                               Corporation
----------------------------------------------------------------------------------------------------------------------------------
1     Glassware Washer Electric Heat &      B      980743       13927                                          Lancer, USA Inc.
      Jet Racks
----------------------------------------------------------------------------------------------------------------------------------
1     Master Track Shelving System          DG     980853       6009              OHT 13.25                    Labrepco
----------------------------------------------------------------------------------------------------------------------------------
2     SGI 02 Workstations                   JS     981200       82678          W10-195S-4G64                   RCH Products, Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     Buchi Rotvapor 29/42 joint            JJ     981247       U81347156            954742                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Freezer Isotmp 51CFT                  DG     981296       U81732622          13990146                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Refrig/Freezer CFC-Free 115V          CM     981297       U81334377         13986106A                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Origin 2000 Computer Server           JS     981300       82684                                          RCH Products, Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     Flash 12I + 401 Cartridge Column      SM     981303       7626           SF-120-15170                    Biotage
      System
----------------------------------------------------------------------------------------------------------------------------------
1     Vacuum pump 5.6 CFM MDL M             NS     981342       U81418666           012578C                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Balance STD-LV                        NS     981379       U81419068           1909377                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Balance 2100G* 0.01G STD              NS     981379       U81419068            191886                    Fisher Scientiifc
----------------------------------------------------------------------------------------------------------------------------------
1     Bio Safety Cabinet & Single           CM     981406       2707980                                        Forma Scientific
      Chmbr. Incubator
----------------------------------------------------------------------------------------------------------------------------------
1     Rotavapor 24/40 R124C                 SK     981428       U81487170            954741                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Vacum pump 5.6 CFM MDL M              MP     981430       U81487156            12578C                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     ESI Probe                             BT     981461       S-022750-012                                   Finnegan Corporation
----------------------------------------------------------------------------------------------------------------------------------
1     Finigan LCQ System                    BT     981461       S-02750-011             LCQ                    Finegan Corporation
----------------------------------------------------------------------------------------------------------------------------------
1     Microscope w/Imaging System           CM     981466       62006                 90700            411921  Optical Apparatus
                                                                                                               Co., Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     Gilson 215 Liquid handler             BT     981468       156757                                         Gilson, Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     HPLC System for Mass Spectrometer     BT     981469       188439                                         Shimadzu Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Speedvac w/Bleeder Valve              MP     981483       153461                SC110                    Savant Instruments,
                                                                                                               Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     Hydra-96 Flexchem Dispenser           ZW     981496       10089843          1029-B1-1       MD985980629  Robbins Scientific
                                                                                                               Corp.
----------------------------------------------------------------------------------------------------------------------------------
1     Genius Block Flat Plate               JK     981529       240790              7022519                    Techne Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     Genesis RSP 200/8 Liquid Handler      JK     981548       136113              10-065A              3143  TECAN
----------------------------------------------------------------------------------------------------------------------------------
1     Genesis RSP 20/8 Liquid Handler       DG     981549       136070              10-065A              3142  TECAN
----------------------------------------------------------------------------------------------------------------------------------
1     Fraction Collector, CF1               MP     981590       A81634063           1118737                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Freezer Isotmp                        DG     981607       U81837970          13990128                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Freezer Isotmp                        DG     981607       A81695421          13990128                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Vacuum Pump                           ZA     981608       AB81695427           118220                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Rotavapor 24/40 R 124C(2)             SM     981612       A81706949            954741                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
<S>   <C>                                        <C>            <C>             <C>
-------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ 32MB                   1,929.00       129.00          9728
-------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ 32MB                   1,929.00       1,929.00        9728
-------------------------------------------------------------------------------------
1     Memory for G3                              98.00          98.00           9728
-------------------------------------------------------------------------------------
1     Memory for G3                              98.00          98.00           9728
-------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ 32MB                   1,169.00       1,619.00 NP
-------------------------------------------------------------------------------------
1     64 MB Memory                               98.00          98.00 NP
-------------------------------------------------------------------------------------
1     17" Daytek Monitor                         255.00         255.00 NP
-------------------------------------------------------------------------------------
1     Shipping                                   34.50          34.50 NP
-------------------------------------------------------------------------------------
1     Shipping                                   63.00          63.00 NP
-------------------------------------------------------------------------------------
                                                                112,317.01
-------------------------------------------------------------------------------------
1     2 Position Thermal Sample Changer          3,410.00       3,410.00 NP
-------------------------------------------------------------------------------------
1     Robomax Refurbished                        7,488.00       7,488.00        9258
-------------------------------------------------------------------------------------
1     Robomax Refurbished                        7,488.00       7,488.00        9120
-------------------------------------------------------------------------------------
1     Glassware Washer Electric Heat &           70,126.68      70,126.68       9246
      Jet Racks
-------------------------------------------------------------------------------------
1     Master Track Shelving System               5,571.00       5,571.00        9722
-------------------------------------------------------------------------------------
2     SGI 02 Workstations                        18,599.83      37,199.65       8914
-------------------------------------------------------------------------------------
1     Buchi Rotvapor 29/42 joint                 3,950.00       3,950.00        9153
-------------------------------------------------------------------------------------
1     Freezer Isotmp 51CFT                       5,812.00       5,812.00        9558
-------------------------------------------------------------------------------------
1     Refrig/Freezer CFC-Free 115V               1,59.97        1,159.97        9153
-------------------------------------------------------------------------------------
1     Origin 2000 Computer Server                116,673.00     116,673.00      9005
-------------------------------------------------------------------------------------
1     Flash 12I + 401 Cartridge Column           3,055.00       3,055.00        8943
      System
-------------------------------------------------------------------------------------
1     Vacuum pump 5.6 CFM MDL M                  1,725.00       1,725.00        9153
-------------------------------------------------------------------------------------
1     Balance STD-LV                             2,443.47       2,443.47        9153
-------------------------------------------------------------------------------------
1     Balance 2100G* 0.01G STD                   1,660.17       1,660.17        9153
-------------------------------------------------------------------------------------
1     Bio Safety Cabinet & Single                3,668.20       3,668.20        9161
      Chmbr. Incubator
-------------------------------------------------------------------------------------
1     Rotavapor 24/40 R124C                      3.668.20       3,668.20        9161
-------------------------------------------------------------------------------------
1     Vacum pump 5.6 CFM MDL M                   1,371.15       1,371.15        9153
-------------------------------------------------------------------------------------
1     ESI Probe                                  6,870.00       6,870.00        9219
-------------------------------------------------------------------------------------
1     Finigan LCQ System                         146,500.00     146,500.00      9219
-------------------------------------------------------------------------------------
1     Microscope w/Imaging System                45,208.00      45,208.00       9604
-------------------------------------------------------------------------------------
1     Gilson 215 Liquid handler                  21,442.25      21,442.25       9224
-------------------------------------------------------------------------------------
1     HPLC System for Mass Spectrometer          26,932.60      26,932.60       9282
-------------------------------------------------------------------------------------
1     Speedvac w/Bleeder Valve                   1,985.00       1,985.00        9134
-------------------------------------------------------------------------------------
1     Hydra-96 Flexchem Dispenser                22,325.00      22,325.00       9277
-------------------------------------------------------------------------------------
1     Genius Block Flat Plate                    1,943.00       1,943.00        9140
-------------------------------------------------------------------------------------
1     Genesis RSP 200/8 Liquid Handler           126,539.60     119,777.60      9778
-------------------------------------------------------------------------------------
1     Genesis RSP 20/8 Liquid Handler            126,010.60     126,010.60      9778
-------------------------------------------------------------------------------------
1     Fraction Collector, CF1                    1,418.05       1,418.05        9310
-------------------------------------------------------------------------------------
1     Freezer Isotmp                             (4,815.28)     (4,815.28)      9310
-------------------------------------------------------------------------------------
1     Freezer Isotmp                             4,815.28       4,815.28        9310
-------------------------------------------------------------------------------------
1     Vacuum Pump                                2,100.41       2,100.41        9310
-------------------------------------------------------------------------------------
1     Rotavapor 24/40 R 124C(2)                  7,376.40       7,376.40        9310
-------------------------------------------------------------------------------------
</TABLE>

                                      28
<PAGE>

<TABLE>
<S>   <C>                                   <C>    <C>          <C>             <C>               <C>          <C>
----------------------------------------------------------------------------------------------------------------------------------
1     Balance                               SM     9816123      A81706949           1909377                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Imersion Cooler                       SM     981612       A8170649            1326473                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
2     Balance/STD-LV 210Gx0.1MG             DR     981614       U81700928           1909377                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
4     Vaccum Pump 5.6 CFM MDL M             DR     981614       U81700928           012578C                    Fishcer Scientific
----------------------------------------------------------------------------------------------------------------------------------
2     Dynamax SD-1 Pump System              SK     981617       038 265609B     R0071050032                    Varian
                                                                                                               Chromatography
                                                                                                               Systems
----------------------------------------------------------------------------------------------------------------------------------
1     Innova Heating Shaker Model 4080      MP     981618       207120           M1192-0004         890312655  New Brunswick
                                                                                                               Scientific Co.
----------------------------------------------------------------------------------------------------------------------------------
2     Rotavapor 24/40 R124C(2)              DR     981630       A81695367            954741                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Vacuum Pump                           SK     981721       A81767916            01100A                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Refrigerator/Freezer                  SK     981721       A81767916         13986106A                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Vacuum Oven                           MP     981722       A81767897         13262285A                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Speedvac Component System 110V        MP     981756       153983                 SS22                    Savant Instruments
----------------------------------------------------------------------------------------------------------------------------------
1     Liquid Handler with Pump              MP     981757       157618              2510121                    Gilson, Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     Shipping                              MP     981757       157808                                         Gilson, Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     4 x 750 Rotor for marathon 3000       KR     981769       H81821526           4976008                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Marathon 3000 Centrifuge              KR     981769       H81821526          49773000                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Centrifuge MDL 5415C 115V             KR     981769       H81821526            540010                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     Analytical Balance                    KR     981769       H81821526         01913503C                    Fisher Scientific
----------------------------------------------------------------------------------------------------------------------------------
1     PTC-100-60 W Hot Bonnet               MC     9819902      50516              PTC-1160             18213  M.J. Research, Inc.
----------------------------------------------------------------------------------------------------------------------------------
2     Genius 384 Well System                JK     981964       241179                20000                    Techne Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     MZ 2C Diaphragm Pump                  NS     981992       609                  696244       20910011-98  Vacuubrand
----------------------------------------------------------------------------------------------------------------------------------
1     Speedvac w/Bleeder Valve              NS     982044       155122                SC100                    Savant Instruments,
                                                                                                               Inc.
----------------------------------------------------------------------------------------------------------------------------------
1     Master Track Shelving System          JK     982146       N0030523                                       Melles Griot
----------------------------------------------------------------------------------------------------------------------------------
1     Evaporative Light Scattering          SE     982261       4439               SED55001                    Richard Scientific
      Detector
----------------------------------------------------------------------------------------------------------------------------------
1     X-Ray System                                                                                             Comdisco
----------------------------------------------------------------------------------------------------------------------------------

----------------------------------------------------------------------------------------------------------------------------------
1     Server, Cleint, and Jukebox           JM     981361       3754                                           Software Moguls,
      License                                                                                                  Inc.
----------------------------------------------------------------------------------------------------------------------------------

----------------------------------------------------------------------------------------------------------------------------------

----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
<S>   <C>                                        <C>            <C>             <C>
-------------------------------------------------------------------------------------
1     Balance                                    2,443.47       2,443.47        9310
-------------------------------------------------------------------------------------
1     Imersion Cooler                            1,039.79       1,039.79        9310
-------------------------------------------------------------------------------------
2     Balance/STD-LV 210Gx0.1MG                  2,443.47       4,886.94        9310
-------------------------------------------------------------------------------------
4     Vaccum Pump 5.6 CFM MDL M                  1,215.34       4,861.36        9310
-------------------------------------------------------------------------------------
2     Dynamax SD-1 Pump System                   20,446.18      40,892.36       9298
-------------------------------------------------------------------------------------
1     Innova Heating Shaker Model 4080           5,350.00       5,350.00        9309
-------------------------------------------------------------------------------------
2     Rotavapor 24/40 R124C(2)                   3,679.93       7,359.86        9310
-------------------------------------------------------------------------------------
1     Vacuum Pump                                1,568.31       1,568.31        9310
-------------------------------------------------------------------------------------
1     Refrigerator/Freezer                       1,111.64       1,111.64        9310
-------------------------------------------------------------------------------------
1     Vacuum Oven                                1,691.67       1,691.67        9310
-------------------------------------------------------------------------------------
1     Speedvac Component System 110V             10,950.75      10,950.75       9279
-------------------------------------------------------------------------------------
1     Liquid Handler with Pump                   13,595.75      13,595.75       9224
-------------------------------------------------------------------------------------
1     Shipping                                                                  9562
-------------------------------------------------------------------------------------
1     4 x 750 Rotor for marathon 3000            2,361.11       2,361.11        9558
-------------------------------------------------------------------------------------
1     Marathon 3000 Centrifuge                   3,538.50       3,538.50        9558
-------------------------------------------------------------------------------------
1     Centrifuge MDL 5415C 115V                  1,676.12       1,676.12        9558
-------------------------------------------------------------------------------------
1     Analytical Balance                         1,871.88       1,871.88        9558
-------------------------------------------------------------------------------------
1     PTC-100-60 W Hot Bonnet                    4,811.00       4,811.00        9737
-------------------------------------------------------------------------------------
2     Genius 384 Well System                     4,152.00       8,304.00        9626
-------------------------------------------------------------------------------------
1     MZ 2C Diaphragm Pump                       1,965.00       1,965.00        9635
-------------------------------------------------------------------------------------
1     Speedvac w/Bleeder Valve                   1,985.00       1,985.00        9619
-------------------------------------------------------------------------------------
1     Master Track Shelving System               1,645.05       1,645.05        9776
-------------------------------------------------------------------------------------
1     Evaporative Light Scattering               14,950.00      14,950.00       9753
      Detector
-------------------------------------------------------------------------------------
1     X-Ray System                               83,483.75      83,483.75
-------------------------------------------------------------------------------------
                                                                1,046.443.95
-------------------------------------------------------------------------------------
1     Server, Cleint, and Jukebox                13,595.00      13,595.00       8917
      License
-------------------------------------------------------------------------------------
                                                                13,595.00
-------------------------------------------------------------------------------------
                                                                1,172,355.96
-------------------------------------------------------------------------------------
</TABLE>

                                      29
<PAGE>

                           PAYMENT ADJUSTMENT RIDER
                           ------------------------

     Rider to Schedule No. 02 dated September 25, 1998 to Master Loan and
Security Agreement No. 7110 dated June 18, 1998 (the "CONTRACT") Between 3-
Dimensional Pharmaceuticals, Inc. as Borrower (the "OBLIGOR") AND PHOENIXCOR,
INC. as Lender ("P.C.").

     23.  Purpose. This Rider sets forth the terms of adjustment to the payments
          -------
set forth in the Contract.

     24.  Definitions. The following terms shall have the following meanings
          -----------
herein:

          (a)  "Adjustment Date" shall mean the date P.C. disburses any portion
of the proceeds of the Contract.

          (b)  "Final T-Note Average" shall mean the average of the yields on
the U.S. Treasury Notes maturing in 4 years, as published by the Dow Jones
Telerate Access Service, Page 19901, for the close of business on each business
day of the two full calendar weeks immediately preceding the week containing the
Adjustment Date.

          (c)  "Preliminary Payments" shall mean the payments set forth in the
Contract, consisting or ($30,200.56 due upon execution followed by) 46
consecutive (monthly or quarterly) payments in the amount of $30,200.56
commencing 30 days after the Adjustment Date, following by one monthly payment
of $122,388.40.

          (d)  "Preliminary T-Note Average" shall mean 5.41%.

     25.  Adjustment of Payments. The Preliminary Payments were calculated based
          ----------------------
on a spread over the Preliminary T-Note Average. If the Adjustment Date occurs
after June 17, 1998 and the Final T-Note Average exceeds the Preliminary T-Note
Average, then the Preliminary Payments shall be revised. For each increase or
decrease of one (1) basis point (i.e., 1/100 of 1%) in the Final T-Note Average
above the Preliminary T-Note Average, the Preliminary Payments shall be revised
as follows (complete below as applicable):

 .    The $30,200.56 payment due upon execution shall remain unchanged.

 .    Each of the 46 payments in the amount of $30,200.56 shall increase or
     decrease by $6.12.

Immediately after the determination of the revised payments due under the
Contract, Obligor shall, at the request of P.C. execute an acknowledgement
reflecting the revised payment schedule and, if requested by P.C. a Replacement
Contract containing the agreed to payments, but the failure of P.C. to make such
a request or the failure of Obligor to execute the acknowledgement or
Replacement Contract shall in no way diminish Obligor's obligations hereunder.

     26.  P.C.'s Requirements. The Commencement of the contract is subject to
satisfaction of all documentation and credit requirements of P.C. If such
requirements are not satisfied by the Adjustment Date, then at P.C.'s option,
the Adjustment Date shall be the date when such requirements are satisfied.

The calculation of the Contract Payments under this Rider will supersede any
prior proposal or quotation.

     IN WITNESS WHEREOF, the parties have executed this Rider simultaneously
with the Contract.

PHOENIXCOR, INC.                          3-Dimensional Pharmaceuticals, Inc.

By: _______________________________       By: _________________________________

Title: ____________________________       Title: ______________________________

                                      30
<PAGE>

                           PAYMENT ADJUSTMENT RIDER
                           ------------------------

     Rider to Schedule No. 02 dated September 25, 1998 to Master Loan and
Security Agreement No. 7110 dated June 18, 1998 (the "CONTRACT") Between
3-Dimensional Pharmaceuticals, Inc. as Borrower (the "OBLIGOR") AND PHOENIXCOR,
INC. as Lender ("P.C.").

     27.  Purpose. This Rider sets forth the terms of adjustment to the payments
          -------
set forth in the Contract.

     28.  Definitions. The following terms shall have the following meanings
          -----------
herein:

          (a)  "Adjustment Date" shall mean the date P.C. disburses any portion
of the proceeds of the Contract.

          (b)  "Final T-Note Average" shall mean the average of the yields on
the U.S. Treasury Notes maturing in 4 years, as published by the Dow Jones
Telerate Access Service, Page 19901, for the close of business on each business
day of the two full calendar weeks immediately preceding the week containing the
Adjustment Date.

          (c)  "Preliminary Payments" shall mean the payments set forth in the
Contract, consisting or ($30,200.56 due upon execution followed by) 46
consecutive (monthly or quarterly) payments in the amount of $30,200.56
commencing 30 days after the Adjustment Date, following by one monthly payment
of $122,388.40.

          (d)  "Preliminary T-Note Average" shall mean 5.41%.

     29.  Adjustment of Payments. The Preliminary Payments were calculated based
          ----------------------
on a spread over the Preliminary T-Note Average. If the Adjustment Date occurs
after June 17, 1998 and the Final T-Note Average exceeds the Preliminary T-Note
Average, then the Preliminary Payments shall be revised. For each increase or
decrease of one (1) basis point (i.e., 1/100 of 1%) in the Final T-Note Average
above the Preliminary T-Note Average, the Preliminary Payments shall be revised
as follows (complete below as applicable):

 .    The $30,200.56 payment due upon execution shall remain unchanged.

 .    Each of the 46 payments in the amount of $30,200.56 shall increase or
     decrease by $6.12.

Immediately after the determination of the revised payments due under the
Contract, Obligor shall, at the request of P.C. execute an acknowledgement
reflecting the revised payment schedule and, if requested by P.C. a Replacement
Contract containing the agreed to payments, but the failure of P.C. to make such
a request or the failure of Obligor to execute the acknowledgement or
Replacement Contract shall in no way diminish Obligor's obligations hereunder.

     30.  P.C.'s Requirements. The Commencement of the contract is subject to
satisfaction of all documentation and credit requirements of P.C. If such
requirements are not satisfied by the Adjustment Date, then at P.C.'s option,
the Adjustment Date shall be the date when such requirements are satisfied.

The calculation of the Contract Payments under this Rider will supersede any
prior proposal or quotation.

     IN WITNESS WHEREOF, the parties have executed this Rider simultaneously
with the Contract.

PHOENIXCOR, INC.                          3-Dimensional Pharmaceuticals, Inc.

By: _______________________________       By: _________________________________

Title: ____________________________       Title: ______________________________

                                      31
<PAGE>

                               PHOENIXCOR, INC.
                                65 WATER STREET
                            SOUTH NORWALK, CT 07854
                    203-855-0030 (PHONE) 203-866-3593 (FAX)

3-Dimensional Pharmaceuticals, Inc.
Eagleview Corporate Center, 665 Stockton Drive, suite 104
Exton, PA 19341

     Re: Equipment Schedule #02 dated September 25, 1998

Ladies and Gentlemen:

Phoenixcor, Inc. requires insurance coverage with companies and in form
satisfactory to it as one of the conditions to enter into the above described
lease or loan with your Company covering the Equipment listed on the attached
schedule or exhibit. This insurance must be carried throughout the term of the
lease/loan. Please sign and return this letter. Please forward a copy of this
letter to your insurance company to process a certificate with the following
requirements:

PROPERTY COVERAGE:
-----------------
 .    Covering all risks of physical loss, damage, destruction or theft of the
     Equipment, with extended coverage.
 .    Loss payable to PHOENIXCOR, INC. AND ITS ASSIGNS.
 .    In an amount equal to not less than the Equipment's full replacement
     value of $1,223,883.96.

LIABILITY COVERAGE:
------------------
 .    $5,000,000.00 combined single limit for each occurrence general liability
     coverage.
 .    Naming PHOENIXCOR, INC. AND ITS ASSIGNS as Additional Insured

PROPERTY AND LIABLITY COVERAGE:
------------------------------
 .    The Equipment should be described specifically or by reference to an
     attached schedule or exhibit or by reference to the above lease or loan
     and account number.
 .    Carrier should be rated A-, VIII (or better) by A.M. Best Company.
 .    Notices to Phoenixcor, Inc. are to be sent to 65 water Street, South
     Norwalk, Connecticut 06854.

Attached is a sample insurance certificate. Additional provisions may be
required for vehicles or other specialized collateral or if otherwise applicable
to the transaction.

ADDIITONAL POLICY PROVISIONS:
----------------------------
 .    The polices must provide that they will not be canceled or altered without
     thirty (30) days prior written notice to PHOENIXCOR, INC.
 .    The policies insuring against loss, damage, destruction or theft must
     provide that the coverage will not be invalidated against PHOENIX, INC. AND
     ITS ASSIGNS because of any violation of any condition or warranty contained
     in any policy or application therefor by the insured or others.

Please feel free to contact or have your insurance agent contact Joan Kossoff at
your earliest convenience. Please be aware that failure to have an insurance
certificate in effect that meets the above requirements will delay the
commencement and/or funding of the above lease or loan.

Very truly yours,                        AGREED TO AND ACCEPTED BY;
PHOENIXCOR, INC.                         3 Dimensional Pharmaceuticals, Inc.

                                         BY: _______________________________

                                         TITLE: ____________________________

                                      32
<PAGE>

                                     CHART

                                      33
<PAGE>

                               LANDLORD'S WAIVER
                               -----------------

     THIS LANDLORD'S WAIVER is made June 30, 1998, by EAGLEVIEW TECHNOLOGY
PARTNERS, having an address c/o The Hankin Group at 717 Constitution Drive,
Eagleview Corporate Center, Exton, PA 19341 ("Landlord"), in favor PHOENIXCOR,
INC., having an address at 65 Water Street, South Norwalk, CT 06854 ("Secured
Party"), against the following background.

                                  BACKGROUND
                                  ----------

     A.   By Office Lease Agreement dated December 12, 1997 (as amended,
"Lease"), Landlord leased to 3-DIMENSIONAL PHARMACEUTICALS, INC. ("Tenant")
certain premises containing approximately 30,411 square feet ("Premise") within
a building know as Eagleview Corporate Center, 665 Stockton Drive, Exton, PA
19341.

     B.   Secured Party has or may extend credit to Tenant, and as security
therefor, Tenant has or is about to grant to Secured Party a security interest
(the "Priority Security Interest") in the following collateral, some or all of
which may now or hereafter be located at the Premises: the equipment and other
items of personal property as described in the Schedules attached to that
certain Master Loan and Security Agreement between Security Party and Tenant,
including all present and future additions, attachments, replacements,
accessoions and accessories thereto (all of the foregoing, together with all
products and proceeds thereof and all improvements and replacements thereof and
additions thereto, but specifically excluding the "Trade Fixtures" as defined
under Section 7(f)(ii) of the Lease, are herein collectively called the
"Collateral").

     NOW, THEREFORE, for value received and intending to be legally bound
hereby, Landlord and Secured Party agree as follows:

     1.   Landlord hereby waives, relinquishes and releases to the Secured Party
any and all liens, security interests, claims, demands and rights, including
without limitation the right to levy or distraint for unpaid rent, which
Landlord now has or hereafter may have with respect to the Collateral, except
the right to levy upon such Collateral in execution of any judgment obtained by
Landlord against Tenant, the lien of which levy shall be subordinate to the
Priority Security Interest.

     2.   Landlord agrees that the Collateral shall at all times be considered
personal property and shall not become fixtures, real estate or part of the
Premises.

     3.   Landlord agrees that Secured Party may, after notice to Landlord and
at a time approved by Landlord (which approval shall not be unreasonably
withheld or delayed), enter upon the Premises and remove the Collateral.
Security Party shall reimburse Landlord for the reasonable cost of repairing any
damage done to the Premises as a result of Secured Party's removal of the
Collateral.

     4.   Secured Party shall indemnify, defend and hold harmless Landlord from
(a) all direct costs incurred by Landlord arising solely from the removal of the
Collateral and the exercise of Secured Party's rights under this Agreement and
the Master Loan and Security Agreement, and (b) any and all claims, actions,
damages, liabilities and expenses in connection with bodily injury or property
damage occasioned by Secured Party's entry on the Premises and/or removal of the
Collateral. Tenant hereby releases Landlord from any and all claims, suits and
damages that Tenant may now or hereafter have arising out of or relating to the
Secured Party's removal of the Collateral and exercise of its rights and
remedies under this Waiver and the Master Loan and Security Agreement.

     5.   In the event the Premises are vacated by Tenant, Landlord shall incur
no liability by reason of Landlord's action or inaction with respect to the
Collateral, and, within forty-five (45) days following notice from Landlord,
Secured Party shall remove all Collateral from the Premises and shall release
its security interest of record, if applicable. If within such forty-five (45)
day period Secured Party fails to (a) remove the Collateral or notify Landlord
in writing that Secured Party has abandoned such property and (b) release its
security interest of record, if applicable, then thereafter Secured Party shall
be deemed to be a tenant of the Premises under all of the terms and conditions
of the Lease until such time as the Collateral is removed and Secured Party
shall pay to Landlord, in advance, rent and operating expenses (as described in
the Lease) at the rates then applicable under the

                                      34
<PAGE>

Lease for each day that the Collateral remains in the Premises and (ii) Landlord
may remove the Collateral and Secured Party shall reimburse Landlord,
immediately following Landlord's demand, for the costs of such removal and
reasonable storage costs for the Collateral. Notwithstanding the foregoing, in
addition to the remedies set forth above, in the event that following vacation
of the Premises by Tenant, Secured Party shall fail to remove the Collateral
from the Premises and release its security interest of record or notify Landlord
in writing that Secured Party has abandoned the same and released its security
of interest of record, then Secured Party shall reimburse Landlord for
reasonable storage costs for the Collateral beginning as of the date of
Landlord's notice to Secured Party that the Premises have been vacated by
Tenant.

     6.   In the event of Secured Party's refusal in accordance with the
foregoing to pay Landlord or to release its security interest of record, if
applicable, all legal expenses incurred by Landlord in enforcing its rights
hereunder shall be paid for by Secured Party.

     7.   This Landlord's Waiver shall be void and of no legal effect unless,
within thirty (30) days after the date it has been signed by Landlord, (a)
Tenant acknowledges its agreement with the foregoing by signing this Landlord's
Waiver, (b) Secured Party signs this Landlord's Waiver, and (c) a fully signed
and dated original hereof is delivered to Landlord at the address stated in the
heading of this instrument. All notices to Secured Party shall be given at the
address for Secured Party stated in the heading of this instrument. All notices
shall be effective on the two business days after the date sent by certified
mail, return receipt requested, postage prepaid, or the next business day after
being send by Federal Express or similar nationally recognized overnight
courier.

     IN WITNESS WHEREOF, the Landlord has duly executed and delivered this
Landlord's Waiver as of the day and date first above written.

                                             LANDLORD:

WITNESS:                                     EAGLEVIEW TECHNOLOGIES PARTNERS

BY:      ______________________________      BY:   ____________________________
Name:                                        Name:
Title:                                       Title:

                                             SECURED PARTY:

WITNESS:                                     PHOENIXCOR, INC.

BY:      ______________________________      BY:   ____________________________
Name:                                        Name:
Title:                                       Title:

Agreed to by:

3-DIMENSIONAL PHARMACEUTICALS, INC.

By:      ______________________________
Name:
Title:

                                      35
<PAGE>

                                     DEED
                                     ----

     THIS INDENTURE made the 28/th/ day of March in the year of our Lord one
thousand nine hundred ninety-five (1995), between THE HANKIN GROUP, a
Pennsylvania partnership, hereinafter called the Grantor, of the one part,

                                      AND
     CHESTER COUNT DEVELOPMENT COUNCIL, a Pennsylvania nonprofit corporation,
hereinafter called the Grantee, of the other party,

     WITNESSETH, that the said Grantor, for and in consideration of the sum of
One Dollar, lawful money of the United States of America, and other good and
valuable consideration unto it well and truly paid by the said Grantee, at or
before the sealing and delivery, hereof, the receipt where of is hereby
acknowledged, has granted, bargained and sold, aliened, enfeoffed, released and
confirmed, and by these presents does grant, bargain and sell, alien, enfeoff,
release and confirm unto the said Grantee, its Successors and Assigns,

     ALL THAT CERTAIN PARCEL OF LAND with buildings and improvements thereon
erected situate in Uwchlan Township, Chester County, Pennsylvania know as Lot
#28, Eagleview Corporate Center, more fully bounded and described in Exhibit "A"
attached hereto.

     TOGETHER with all and singular, the structures, improvements, ways,
streets, alleys, passages, waters, watercourses, mineral rights and timber
rights, if any, liberties, privileges, hereditaments and appurtenances,
whatsoever thereunto belonging, or in any wise appertaining, and the reversions
and remainders, rents, issues and profits thereof; and all the estate, right,
title, interest, property, claim and demand whatsoever of it the said Grantor in
law as in equity, or otherwise howsoever, of, in and to the same and every part
thereof.

     TO HAVE AND TO HOLD, the said parcel of land above described, with the
improvements and structures thereon erected and the hereditaments and premises
hereby granted, or mentioned and intended so to be, with the appurtenances, unto
the said Grantee, its Successors and Assigns, to and for the only proper use and
behoof of the said Grantee, its Successors and Assigns forever, in fee.

     UNDER AND SUBJECT to the matters of record.

     AND the said Grantor, for itself and its Successors, does by these
presents, covenant, grant and agree, to and with the said Grantee, its
Successors and Assigns, that it, the said Grantor and its Successors, all and
singular the hereditaments and premises hereinabove described and granted, or
mentioned and intended so to be, with appurtenances, unto the said Grantee, its
Successors and Assigns, against it, the said Grantor and its Successors and
Assigns, and against all and every person or persons whomsoever lawfully
claiming or to claim the same or any part thereof, by, from or under Grantor, or
any of them, shall and will, subject as aforesaid, WARRANT and forever DEFEND.

     IN WITNESS WHEREOF, the said Grantor has caused these presents to be
executed and its common or corporate seal to be hereto affixed, duly attested,
dated the day and year first above written.

WITNESS:                                   GRANTOR:

                                           THE HANKIN GROUP, a Partners

____________________________________       By: _______________________________
                                               Robert S. Hankin, Partner

I hereby certify that the address of the above Grantee is:

                                      36
<PAGE>

Chester County Development Council
750 Pottstown Pike
Exton, PA  19341

________________________
On behalf of the Grantee

--------------------------------------------
COMMONWEALTH OF PENNSYLVANIA           :
--------------------------------------------
                                       :  ss
--------------------------------------------
COUNTY OF CHESTER                      :
--------------------------------------------

     On this, the ____ day of ________, before me, a Notary Public, the
Undersigned officer personally appeared, Robert S. Hankin, known to me (or
satisfactorily proven) to be the general partner of The Hankin Group, a
Pennsylvania partnership, and acknowledged that he, as such officer, being
authorized to do so, executed the foregoing instrument for the purposes therein
contained by signing the name of the partnership as such partner.

     IN WITNESS WHEREOF, I hereunto set my hand and seal.

                                                 _____________________
                                                 Notary Public

My Commission Expires:

                                      37
<PAGE>

                                  EXHIBIT "A"
                                  -----------

     ALL THAT CERTAIN lot or piece of ground with buildings and improvements
thereon arected situate in the Township of Uwchlan, County of Chester,
Commonwealth of Pennsylvania bounded and described according to a Plan or
Subdivision of Eagleview Corporate Center made by Chester Valley Engineers,
Inc., of Paoli, PA dated 2/18/1987 and last revised 3/28/1994, as follows, to
wit:

     Beginning at a point on the Northeast side of Stockton Drive, 60 feet wide,
said point being measured the two following courses and distances from a point
of curve on the Northwest side of an unnamed Boulevard, 60 feet wide, (1) on the
arc of a circle curving to the right having a radius of 30.00 feet the arc
distance of 47.30 feet to a point of tangent on the Northeast side of said
Stockton Drive (2) North 50 degrees 20 minutes 46 seconds West 2358.83 feet to
the point of beginning; thence from said beginning point and along said Stockton
Drive the two following courses and distances (1) North 50 degrees 20 minutes 46
seconds West 315.28 to a point of curve (2) on the arc of a circule curving to
the right having a radius of 320.00 feet the arc distance of 45.90 feet to a
point a corner of remaining lands of Hankin; thence along the same North 39
degrees 19 minutes 02 seconds East 527.95 feet, crossing the bed of a 30 feet
wide sanitary sewere easement, to a point in line of Lot #31 of said Plan;
thence along the same and along the Northeast side of said easement, South 51
degrees 41 minutes 33 seconds East 161.06 feet to a point; thence continuing
along said Lot #31, North 38 degrees 18 minutes 27 seconds East 38.72 feet to a
point a corner of Lot #30 of said Plan; thence along the same South 16 degrees
41 minutes 33 seconds East 234.52 feet to a point; thence continuing along said
Lot #30, South 50 degrees 40 minutes 38 seconds East 6.19 feet to a point a
corner of Lot #28 of said Plan; thence along the same, recrossing said sanitary
sewer easement, South 39 degrees 19 minutes 02 seconds West 443.80 feet to the
first mentioned point and place of beginning.

     CONTAINING:  4.295 acres be, the same more or less.

     BEING Lot #28 of the above mentioned Plan.

     BEING part of the same premises which Bannercroft Clothing Company, Inc. (a
PA Corporation) by Indenture bearing date the 16/th/ day of December, A.D. 1985
and duly recorded at West Chester in the Office for the Recording of Deeds, in
and for the County of Chester on the 19/th/ day of December A.D. 198o5 in Record
Book 166 page 85, granted and conveyed unto The Hankin Grooup, a Partnership, in
fee.

                                      38
<PAGE>

                               PHOENIXCOR, INC.
                                 65 WATER ST.
                             S. NORWALK, CT 06854

June 18, 199
------------

3-Dimensional Plharmaceuticals, Inc.
Eagleview Corporate Center, 685 Stockton Drive, suite 104
Exton, PA 19341

Gentlemen:

          Reference is made to a certain Master Loan and Security Agreement No.
7110 dated June 18, 1998 and all related Schedules between Phoenixcor, Inc as
           -------------
Lender (the "Lender") and 3-Dimensional Pharmaceuticals, Inc. (as Borrower (the
"Borrower").

         Provided that the Borrower is not then in default and never has been in
default under the Contract, and has timely paid at least the first twenty-four
(24) monthly payments due under the Contract (exclusively of any advance payment
due upon execution) Borrower shall have the right, upon at least thirty (30)
days prior written notice to the Lender, to prepay the Contract on the periodic
installment due date designated in such notice by paying to the Lender the sum
of (1) the then outstanding principal balance of the Contract (calculated on a
simple interest basis) plus (ii) a premium of 3% during Year 3 and a premium of
1/5% during Year 4. The premium applicable with the calculated on the then
outstanding principal balance. Year 3 will mean the period consisting of the
25th through the 38th installments under the Contract (exclusive of any advance
payment due upon execution) and subsequent years will refer to the subsequent
twelve monthly payment periods.

                                                    Very truly yours,

                                                    PHOENIXCOR, INC.

AGREED TO:

3-Dimensional Pharmaceuticals, Inc.

BY: __________________

TITLE: _______________

                                      39
<PAGE>

--------------------------------------------------------------------------------
Phoenixcor Schedule 2                                       1/15/99     Page 1
--------------------------------------------------------------------------------

Compound Period.............:    Monthly
Nominal Annual Rate.........:    10.942%
Effective Annual Rate........    11.508%
Periodic Rate................    0.9119%
Daily Rate...................      0.02998%
CASH FLOW DATA

--------------------------------------------------------------------------------
     Event      Start Date          Amount  Number     Period       End Date
--------------------------------------------------------------------------------
1    Loan       10/01/1998    1,223,883.96       1
--------------------------------------------------------------------------------
2    Payment    10/01/1998       30,200.56       1
--------------------------------------------------------------------------------
3    Payment    11/01/1998       29,753.80      46     Monthly    08/01/2002
--------------------------------------------------------------------------------
4    Payment    09/01/2002     122,388,.40       1
--------------------------------------------------------------------------------

AMORTIZATION SCHEDULE - Normal Amortization
--------------------------------------------------------------------------------
        Date          Payment      Interest      Principal       Balance
--------------------------------------------------------------------------------
Loan    10/01/1998                                                  1,223,883.96
--------------------------------------------------------------------------------

1       10/01/1998      30,200.56         0.00       30,200.56      1,193,683.40
--------------------------------------------------------------------------------
2       11/01/1998      29,753.80    10,884.72       18,869.08      1,174,814.37
--------------------------------------------------------------------------------
3       12/01/1998      29,753.80    10,712.66       19,041.14      1,155,773.18
--------------------------------------------------------------------------------
        1998 Totals     89,708.16    21,597.38       68,110.78
--------------------------------------------------------------------------------
4       01/01/1999      29,753.80    10,539.04       19,214.76      1,136,558.42
--------------------------------------------------------------------------------
5       02/01/1999      29,753.80    10,363.82       19,389.98      1,117,168.44
--------------------------------------------------------------------------------
6       03/01/1999      29,753.80    10,187.01       19,566.79      1,097,601.65
--------------------------------------------------------------------------------
7       04/01/1999      29,753.80    10,008.59       19,745.21      1,077,856.44
--------------------------------------------------------------------------------
8       05/01/1999      29,753.80     9,828.54       19,925.26      1,057,931.18
--------------------------------------------------------------------------------
9       06/01/1999      29,753.80     9,646.85       20,106.95      1,037,824.23
--------------------------------------------------------------------------------
10      07/01/1999      29,753.80     9,463.51       20,290.29      1,017,533.94
--------------------------------------------------------------------------------
11      08/01/1999      29,753.80     9,278.49       20,475.31        997,058.63
--------------------------------------------------------------------------------
12      09/01/1999      29,753.80     9,091.78       20,662.02        976,396.61
--------------------------------------------------------------------------------
13      10/01/1999      29,753.80     8,903.37       20,850.43        955,546.18
--------------------------------------------------------------------------------
14      11/01/1999      29,753.80     8,713.25       21,040.55        934,505.63
--------------------------------------------------------------------------------
15      12/01/1999      29,753.80     8,521.38       21,232.42        913,273.21
--------------------------------------------------------------------------------
        1999 Totals                 114,545.63      242,499.97
--------------------------------------------------------------------------------
16      01/01/2000      29,753.80     8,327.77       21,426.03        891,847.18
--------------------------------------------------------------------------------
17      02/01/2000      29,753.80     8,132.40       21,621.40        870,225.78
--------------------------------------------------------------------------------
18      03/01/2000      29,753.80     7,935.24       21,818.56        848,407.22
--------------------------------------------------------------------------------
19      04/01/2000      29,753.80     7,736.29       22,017.51        826,389.71
--------------------------------------------------------------------------------
20      05/01/2000      29,753.80     7,535.52       22,218.28        804,171.43
--------------------------------------------------------------------------------
21      06/01/2000      29,753.80     7,332.92       22,420.88        781,750.55
--------------------------------------------------------------------------------
22      07/01/2000      29,753.80     7,128.47       22,625.33        759,125.22
--------------------------------------------------------------------------------
23      08/01/2000      29,753.80     6,922.16       22,831.64        736,293.58
--------------------------------------------------------------------------------
24      09/01/2000      29,753.80     6,713.97       23,039.83        713,253.75
--------------------------------------------------------------------------------
25      10/01/2000      29,753.80     6,503.88       23,249.92        690,003.83
--------------------------------------------------------------------------------
26      11/01/2000      29,753.80     6,291.87       23,461.93        666,541.90
--------------------------------------------------------------------------------
27      12/01/2000      29,753.80     6.077.93       23,675.87        642,866.03
--------------------------------------------------------------------------------
        2000 Totals     86,638.42    86,638.42      270,407.18
--------------------------------------------------------------------------------
28      01/01/2001      29,753.80     5,862.04       23,891.76        618,974.27
--------------------------------------------------------------------------------

                                      40
<PAGE>

--------------------------------------------------------------------------------
29      02/01/2001       29,753.80     5,644.18      24,109.62       594,864.65
--------------------------------------------------------------------------------
30      03/01/2001       29,753.80     5,424.33      24,329.47       570,535.18
--------------------------------------------------------------------------------
31      04/01/2001       29,753.80     5,202.48      24,551.32       545,983.86
--------------------------------------------------------------------------------
32      05/01/2001       29,753.80     4,978.61      24,775.19       521,208.67
--------------------------------------------------------------------------------
33      06/01/2001       29,753.80     4,752.69      25,001.11       496,207.56
--------------------------------------------------------------------------------
34      07/01/2001       29,753.80     4,524.72      25,229.08       470,978.48
--------------------------------------------------------------------------------
35      08/01/2001       29,753.80     4,294.67      25,459.13       445,519.35
--------------------------------------------------------------------------------
36      09/01/2001       29,753.80     4,062.51      25,691.29       419,828.06
--------------------------------------------------------------------------------
37      10/01/2001       29,753.80     3,828.24      25,925.56       393,902.50
--------------------------------------------------------------------------------
38      11/01/2001       29,753.80     3,591.84      26,161.96       367,740.54
--------------------------------------------------------------------------------
39      12/01/2001       29,753.80     3,353.28      26,400.52       341,340.02
--------------------------------------------------------------------------------
        2001 Totals                   55,519.59     301,526.01       314,698.76
--------------------------------------------------------------------------------
40      01/01/2002       29,753.80     3,112.54      26,641.26       287,814.57
--------------------------------------------------------------------------------
41      02/01/2002       29,753.80     2,869.61      26,884.19       260,685.24
--------------------------------------------------------------------------------
42      03/01/2002       29,753.80     2,624.47      27,129.33       233,308.52
--------------------------------------------------------------------------------
43      04/01/2002       29,753.80     2,377.08      27,376.72       205,682.17
--------------------------------------------------------------------------------
44      05/01/2002       29,753.80     2,127.45      27,626.35       177,803.90
--------------------------------------------------------------------------------
45      06/01/2002       29,753.80     1,875.53      27,878.27       149,671.42
--------------------------------------------------------------------------------
46      07/01/2002       29,753.80     1,621.32      28,132.48       121,282.41
--------------------------------------------------------------------------------
47      08/01/2002       29,753.80     1,364.79      28,389.01             0.00
--------------------------------------------------------------------------------
48      09/01/2002      122,388.40     1,105.99     121,282.41
--------------------------------------------------------------------------------
        2001 Totals     360,418.80    19,078.78     341,340.02
--------------------------------------------------------------------------------
        Grand Totals  1,521,263.76   297,379.80   1,223,883.96
--------------------------------------------------------------------------------

                                      41
<PAGE>

                                   EXHIBIT A

The following description of property supplements, and is part, Schedule No. 03
                                                                             --
to Master Loan and Security Agreement No. 7110 dated June 18, 1998 between the
                                          ----       -------------
undersigned Borrower and Phoenixcor, Inc. and may be attached to said Loan
Schedule and any related UCC Financing Statements, Acceptance or Delivery
Certificate or other document describing the property:

                   See Attached Exhibit A Equipment Schedule

     All property listed above complete with any and all attachments,
accessions, additions, replacements, improvements, modifications and
substitutions there to and therefor and all proceeds including proceeds thereof
and therefrom.

PHOENIXCOR, INC.                        3-Dimensional Pharmaceuticals, Inc.
----------------                        -----------------------------------
(Lender)                                (Borrower)

BY:____________________________         BY:___________________________________

TITLE:_________________________         TITLE:________________________________

                                      42
<PAGE>

<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------------------------------
3-Dimensional Pharmaceuticals, Inc.
Eagleview Corporate Center                           3-Dimensional Pharmaceuticals, Inc.
665 Stockton Drive, Suite 104                               Equipment Financing
Exton, PA 19341
---------------------------------------------------------------------------------------------------------------
Qty   Equipment Description   REQ.    PURCHASE    INVOICE        CATALOG     SERIAL NO.     SUPPLIER/VEN
                                      ORDER       NO.            NO.                        DOR
---------------------------------------------------------------------------------------------------------------
<S>   <C>                     <C>     <C>         <C>            <C>         <C>            <C>
1     Conference Room         BW      981471      18539                                     Office Pavillion
      Furniture
---------------------------------------------------------------------------------------------------------------
1     Meridian Office Systems BW      981859      20321                                     Office Pavillion
      Furniture (3)
---------------------------------------------------------------------------------------------------------------
1     Silver Spring Water     BW      982205      111                                       C.J. Civis
      Cooler Filteration
      System
---------------------------------------------------------------------------------------------------------------
1     MEM PUSER 64MB          JS      982209      C0722496       CHP0542                    MacWarehouse
      SDRAM F/POWER
      MAC
---------------------------------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ     JS      982209      C0711820       CPU0958                    MacWarehouse
      and Memory
---------------------------------------------------------------------------------------------------------------
1     MEM PUSER 4MB SDRAM     JS      982209      C0712182       CHP0542                    MacWarehouse
      F/POWER MAC
---------------------------------------------------------------------------------------------------------------
1     Power MAC G3/266MHZ     JS      982209      C0707117       CPU0958                    MacWarehouse
      and Memory
---------------------------------------------------------------------------------------------------------------
1     Wireless Internet       EJ      982413      5325-00        872401      S2038105       InfoSystems
      Connection
---------------------------------------------------------------------------------------------------------------
1     Wireless Internet       EJ      982413      5325-01        872407      S2028126       InfoSystems
      Connection
---------------------------------------------------------------------------------------------------------------
2     Wireless Internet       EJ      982413      5325-02        872109                     InfoSystems
      Connection
---------------------------------------------------------------------------------------------------------------
1     Power MAC G3/266MHZ     JS      982427      C1490119       CPU0957     SXB8241TNCY4   MacWarehouse
      and Memory
---------------------------------------------------------------------------------------------------------------
1     64mb 168 PIN EDO        JS      982427      C1489889       CHPO0429                   MacWarehouse
      DIMM 60NS 2K Refresh
---------------------------------------------------------------------------------------------------------------
1     MON DAYTEK 17# .28MM    JS      982427      C1469428       MT2377      DV9805J100015  MacWarehouse
---------------------------------------------------------------------------------------------------------------
1     Power Mac G3/233MHZ     JS      982427      C1835032       CPU1204     SXB8302KLD8X   MacWarehouse
      and Memory
---------------------------------------------------------------------------------------------------------------
1     MEM PUSER 64MB          JS      982209      C0712182       CHP0542                    MacWarehouse
      SDRAM F/POWER
      MAC
---------------------------------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ     JS      982209      CO707117       CPU0958                    MacWarehouse
      and Memory
---------------------------------------------------------------------------------------------------------------
1     Wireless Internet       EJ      982413      5325-00        872401      S2038105       InfoSystems
      Connection
---------------------------------------------------------------------------------------------------------------
1     Wireless Internet       EJ      982413      5325-01        872407      S2028126       InfoSystems
---------------------------------------------------------------------------------------------------------------

<CAPTION>
--------------------------------------------------------------------------------------------
3-Dimensional Pharmaceuticals                                                    Exhibit A
Eagleview Corporate Center                                                 Schedule No. 03
665 Stockton Drive, Suite 104
Exton, PA 19341
--------------------------------------------------------------------------------------------
<S>   <C>                                 <C>               <C>            <C>
Qty   Equipment Description               EQUIPMENT         EQUIPMENT      PAID-
                                          COST -            COST           CHECK #
                                          Each
---------------------------------------------------------------------------------------------
1     Conference Room                      5,472.04 $       5,472.04 $     9898
      Furniture
--------------------------------------------------------------------------------------------
1     Meridian Office Systems              6,414.25         6,414.25      10230
      Furniture (3)
--------------------------------------------------------------------------------------------
1     Silver Spring Water                  1,266.70         1,266.70       9694
      Cooler Filteration
      System
--------------------------------------------------------------------------------------------
1     MEM PUSER 64MB                          98.00            98.00       9728
      SDRAM F/POWER
      MAC
--------------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ                  1,929.00         1,929.00       9728
      and Memory
--------------------------------------------------------------------------------------------
1     MEM PUSER 4MB SDRAM                     98.00            98.00       9728
      F/POWER MAC
--------------------------------------------------------------------------------------------
1     Power MAC G3/266MHZ                  2.027.00         2.027.00       9728
      and Memory
--------------------------------------------------------------------------------------------
1     Wireless Internet                    1,293.00         1,293.00       9868
      Connection
--------------------------------------------------------------------------------------------
1     Wireless Internet                    1,769.00         1,769.00       9868
      Connection
--------------------------------------------------------------------------------------------
2     Wireless Internet                      121.00           242.00       9868
      Connection
--------------------------------------------------------------------------------------------
1     Power MAC G3/266MHZ                  1,653.50         1,653.50       9884
      and Memory
-------------------------------------------------------------------------------------------
1     64mb 168 PIN EDO                        98.00            98.00       9884
      DIMM 60NS 2K Refresh
--------------------------------------------------------------------------------------------
1     MON DAYTEK 17# .28MM                   318.00           318.00       9884
--------------------------------------------------------------------------------------------
1     Power Mac G3/233MHZ                  1,522.45         1,522.45       9884
      and Memory
--------------------------------------------------------------------------------------------
1     MEM PUSER 64MB                          98.00            98.00       9728
      SDRAM F/POWER
      MAC
--------------------------------------------------------------------------------------------
1     Power Mac G3/266MHZ                  2,027.00         2,027.00       9728
      and Memory
--------------------------------------------------------------------------------------------
1     Wireless Internet                    1,293.00         1,293.00       9868
      Connection
--------------------------------------------------------------------------------------------
1     Wireless Internet                    1,769.00         1,769.00       9868
--------------------------------------------------------------------------------------------
</TABLE>

                                      43
<PAGE>

<TABLE>
------------------------------------------------------------------------------------------------------------------------------------
<S>                       <C>     <C>        <C>            <C>       <C>            <C>
     Connection
------------------------------------------------------------------------------------------------------------------------------------
2    Wireless Internet     EJ      982413    5325-02        872109                  InfoSystems       121.00     242.00      9868
     Connection
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac G3/266MHZ   JS      982427    C1490119       CPU0957   SXB8241TNC    MacWarehouse      1,653.50   1,653.50    9884
     and Memory                                                       Y4
------------------------------------------------------------------------------------------------------------------------------------
1    64mb 168 PIN EDO      JS      982427    C1489889       CHP02429                MacWarehouse      98.00      98.00       9884
     DIMM 6ONS 2K
     Refresh
------------------------------------------------------------------------------------------------------------------------------------
1    MON KAYTEK 17"        JS      982427    C1469428       MT2377    DV9805J1000   MacWarehouse      318.00     318.00      9884
     28mm                                                             15
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac G3/233MHZ   JS      982537    C1835032       CPU1204   SXB8302KL     MacWarehouse      1,522.45   1,522.45    9884
     & Memory                                                         D8X
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER 64MB        JS      982537    C1792357       CHP5042                 MacWarehouse      98.00      98.00       9884
     SDRAM F/POWER
     MAC
------------------------------------------------------------------------------------------------------------------------------------
1    Sheiving System for   JDF     982587    000705                                 Wolternate        21,782.40  21,782.40   9999
     Chem Storage                                                                   Associates, Inc.
------------------------------------------------------------------------------------------------------------------------------------
1    Sheiving System for   JDF     982587    000724                                 Wolternate        404.48     404.48      9999
     Chem Storage                                                                   Associates, Inc.
------------------------------------------------------------------------------------------------------------------------------------
1    Sheiving System for   JDF     982587    000799                                 Wolternate        2,790.58   2,790.58   10277
     Chem Storage                                                                   Associates, Inc.
------------------------------------------------------------------------------------------------------------------------------------
1    Compaq Presario PC,   JS      982590    C2114320       CP8142                  MacWarehouse      1,906.35   1,906.35    9884
     Memory & Monitor
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER DIMM        JS      982590    C2106086       MY9371                  MacWarehouse      276.75     276.75      9884
     128MB SDRAM
------------------------------------------------------------------------------------------------------------------------------------
1    MON PUSER 17          JS      982590    C2108066       MON0629                 MacWarehouse      264.45     264.45      9884
     .28MM
------------------------------------------------------------------------------------------------------------------------------------
1    Compaq Presario PC    JS      982696    C2295483       CP8142    S6835BX48K    MacWarehouse      1,905.45   1,905.45    9884
     & Memory                                                         304
------------------------------------------------------------------------------------------------------------------------------------
1    Compaq Presario PC    JS      982696    C2295483       CP8142    S6835BX48K    MacWarehouse      1,905.45   1,905.45    9884
     & Memory                                                         040
------------------------------------------------------------------------------------------------------------------------------------
1    Compaq Presario PC    JS      982696    C2295483       CP8142    S6835BX48K    MacWarehouse      1,905.45   1,905.45    9884
     & Memory                                                         096
------------------------------------------------------------------------------------------------------------------------------------
3    MEM PUSER DIMM        JS      982696    C2263721       MY9371                  MacWarehouse      270.00     810.00      9884
     128MB SDRAM
------------------------------------------------------------------------------------------------------------------------------------
3    FAST ETHERLINK XL     JS      982696    C2263721       DEC3165                 MacWarehouse      87.17      261.51      9884
     Pci
------------------------------------------------------------------------------------------------------------------------------------
1    FAST ETHERLINK XL     JS      982696    C2263721       DEC3165                 MacWarehouse      87.19      87.19       9884
     Pci
------------------------------------------------------------------------------------------------------------------------------------
2    (2) Dell ispiron      EJ      982698    182153734      220-0406                Dell              4,279.00   8,558.00    9975
     7000 Computer
------------------------------------------------------------------------------------------------------------------------------------
1    Matrix ES 5000        JS      982719    E0031195       DUP1723                 MacWarehouse      3,840.10   3,840.10    10130
     Backup Power System
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac             JS      982720    C2457349       CPU1204                 MacWarehouse      1,794.40   1,794.40    10130
     G3/266MHZ, Memory
     and Monitor
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER 64MB        J2      982720    C2474146       CHP0542                 MacWarehouse      105.80     105.80      10130
     SDRAM F/POWER MAC
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      44
<PAGE>

<TABLE>
------------------------------------------------------------------------------------------------------------------------------------
<S>  <C>                   <C>     <C>       <C>         <C>       <C>           <C>             <C>           <C>             <C>
1    Power Mac G3/300      JS       982721    C2468999    CPU1202   SXB83702QD    MacWarehouse   2,845.75      2,845.75        10130
     Server, Memory,                                                HY
     Monitor
------------------------------------------------------------------------------------------------------------------------------------
2    MEM PUSER 64MB        JS       982721    C2470490    CHP0542                 MacWarehouse     101.90        203.80        10130
     SDRAM F/POWER
     MAC
------------------------------------------------------------------------------------------------------------------------------------
1    MON PUSER 17          JS       982721    C2448850    MON0629                 MacWarehouse     264.45        264.45        10130
     .28MM
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac             JS       982722    C2467553    CPU1204   SXB8320EFD8                  1,522.45      1,522.45        10130
     G3/266MHZ, Memory                                              X
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER 64MB        JS       982722    C2432060    CHP5042                 MacWarehouse     102.45        102.45        10130
     SDRAM F/POWER MAC
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac G3/300      JS       982810    E0226258    CPU1204   SSG8313HD8    MacWarehouse   1,522.45      1,522.45        10130
     Server, Memory,                                                X
     Monitor
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER 64MB        JS       982810    E0238071    CHP0542                 MacWarehouse     102.85        102.85        10130
     SDRAM F/POWER MAC
------------------------------------------------------------------------------------------------------------------------------------
1    MON OPTQST Q71 17     JS       982810    E0360552    MT2266                  MacWarehouse     258.95        258.95        10130
     .27 MM
------------------------------------------------------------------------------------------------------------------------------------
1    Compaq Deskpro        JS       982811    E0201905    CP7744    S6835BVF2P    MacWarehouse   1,640.20      1,640.20        10130
                                                                        162
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER DIMM        JS       982811    E0216598    MY10230                 MacWarehouse     289.85        298.85        10130
     128MB SDRAM
------------------------------------------------------------------------------------------------------------------------------------
1    MON OPTQST Q71 17"    JS       982811    E0359943    MT2266                  MacWarehouse     258.95        258.95        10130
     .27MM
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac G3/266MHZ   JS       982812    E0218875    CPU1204   SSG321DWD     MacWarehouse   1,522.45      1,522.45        10130
                                                                                       8X
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER 64MB        JS       982812    E0227256    CHP5042                 MacWarehouse     102.85        102.85        10130
     SDRAM F/POWER
     MAC
------------------------------------------------------------------------------------------------------------------------------------
1    MON OPTQST Q71 17"    JS       982812    E0359984    MT2266                  MacWarehouse     258.95        258.95        10130
     .27MM
------------------------------------------------------------------------------------------------------------------------------------
1    Micron Millenia 450   JS       982836    4214349                             Micron         2,673.00      2,673.00        10059
     Mhz Computer System                                                          Electronics
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac G3/266MHZ   JS       982898    E0408047    CPU1204                 MacWarehouse   1,522.45      1,522.45        10130
------------------------------------------------------------------------------------------------------------------------------------
1    MON OPTQUST Q71 17"   JS       982898    E0408047    MT2266                  MacWarehouse     258.95        258.95        10130
     .27MM
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER 64MB        JS       982898    E0401612    CHP5042                 MacWarehouse     102.85        102.85        10130
     SDRAM F/POWER
     MAC
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac G3/266MHZ   JS       982899    E0407833    CPU1204                 MacWarehouse   1,522.45      1,522.45        10130
------------------------------------------------------------------------------------------------------------------------------------
1    MON OPTQST Q71 17"    JS       982899    E0407833    MT2266                  MacWarehouse     258.95        258.95        10130
     .27MM
------------------------------------------------------------------------------------------------------------------------------------
1    MEM PUSER 64MB        JS       982899    E0397141    CHP0542                 MacWarehouse     102.85        102.85        10130
     SDRAM F/POWER
     MAC
------------------------------------------------------------------------------------------------------------------------------------
1    Power Mac G3/266MHZ   JS       982900    E0407817    CPU1204                 MacWarehouse   1,522.45      1,522.45        10130
-----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      45
<PAGE>

<TABLE>
<S> <C>                   <C> <C>       <C>           <C>        <C>           <C>               <C>         <C>          <C>
----------------------------------------------------------------------------------------------------------------------------------
    G3/266MHZ, Memory
    and Monitor
------------------------------------------------------------------------------------------------------------------------------------
1   MON OPTQST Q71 17"    JS  982900    E0407817      MT2266                   MacWarehouse         258.95       258.95   10130
    .27MM
------------------------------------------------------------------------------------------------------------------------------------
1   MEM PUSER 64MB        JS  982900    E0394379      CHP0542                  MacWarehouse         102.85       102.85   10130
    SDRAM F/POWER MAC
------------------------------------------------------------------------------------------------------------------------------------
1   Power Mac G3/266MHZ   JS  982992    E0738393      CPU1204    SXB8320V5DBX  MacWarehouse       1,516.65     1,516.65   10130
------------------------------------------------------------------------------------------------------------------------------------
1   MON OPTQST Q71 17-    JS  982992    E0773275      MT2266                   MacWarehouse         258.95       258.95   10130
    .27MM
------------------------------------------------------------------------------------------------------------------------------------
1   MEM PUSER 64MB        JS  982992    E0743666      CHP0542                  MacWarehouse          98.00        98.00   10130
    SDRAM F/POWER MAC
------------------------------------------------------------------------------------------------------------------------------------
1   Power Mac G3/266MHZ   JS  983098    E1143510      CPU1204    SXB8360Z1D8X  MacWarehouse       1,529.80     1,529.80   10130
------------------------------------------------------------------------------------------------------------------------------------
1   MON OPTQST Q71 .27MM  JS  083098    E1143510      MT2266     8G83608796    MacWarehouse         249.95       249.95   10130
------------------------------------------------------------------------------------------------------------------------------------
1   MEM PUSER 64MB        JS  983098    E1140565      CHP0542                  MacWarehouse         104.75       104.75   10130
    SDRAM F/POWER MAC
------------------------------------------------------------------------------------------------------------------------------------
1   Compaq Deskpro        JS  983009    E1146836      CP7770     S6834BW43L811 MacWarehouse       1,911.55     1,911.55   10130
------------------------------------------------------------------------------------------------------------------------------------
1   MEM PUSER DIMM        JS  983099    E1160951      MY9371                   MacWarehouse         249.65       249.65   10130
    128MB SDRAM
------------------------------------------------------------------------------------------------------------------------------------
1   SG102 Workstation     CD  983398    82856                                  RCH Products       8,457.50     8,457.50   10316
                                                                                                             ----------
------------------------------------------------------------------------------------------------------------------------------------
                                                                               Office Furniture & Equipment  106,496.25
------------------------------------------------------------------------------------------------------------------------------------
                                                                               Total
------------------------------------------------------------------------------------------------------------------------------------
1   Temperature           DG  98053     16107                                  Jordon Scientific 39,950.00    39,950.00   8923, 9974
    Humidity Cold Room                                                         Products
------------------------------------------------------------------------------------------------------------------------------------
1   Isotemp Refrigerator, DG  981067    278404063098  13990128                 Fisher             4,815.28     4,815.28   9310
    45 Cu Ft
------------------------------------------------------------------------------------------------------------------------------------
1   Freezer 21 Cubic      KR  981769    278404063098  13989100                 Fisher             6,121.35     6,121.35   9712
    Ft, -85 Degrees
------------------------------------------------------------------------------------------------------------------------------------
1   General Purpose       KR  981769    278404063098  13986249G                Fisher             3,172.40     3,172.40   9712
    Refrigerator 49
    Cubic Ft.
------------------------------------------------------------------------------------------------------------------------------------
1   Thermal Cycler        MC  981092    50516         PTC-01160  18,213.00     MJ Research        4,811.00     4,811.00   9737
    w/Hot Bonnet
------------------------------------------------------------------------------------------------------------------------------------
1   Outdoor Storage       JDF 981961    278404073198  1798576B                 Fisher             7,800.00     7,800.00   9712
    Cabinets, 6 Drum
    Capacity
------------------------------------------------------------------------------------------------------------------------------------
1   Custom Enclosures     EG  981962    101610                                 H&K Tool &        33,100.36    33,100.36   10033
    for Thermolluor Units                                                      Machine Co.
------------------------------------------------------------------------------------------------------------------------------------
1   AT 200 Electronic     ZW  982036    278404073198  0191011                  Fisher             4,615.80     4,615.80   9712
    Balance
------------------------------------------------------------------------------------------------------------------------------------
1   Vacuum Pump, 5.6 CFM  TM  982037    278404073198  012578C                  Fisher             1,215.34     1,215.34   9712
------------------------------------------------------------------------------------------------------------------------------------
1   5 Place Magnetic      CR  982038    278404073198  1451104                  Fisher             1,095.36     1,095.36   9712
    Stirrer
------------------------------------------------------------------------------------------------------------------------------------
1   Lead Screw Driven     EG  982083    3168          1SCWLSB                  Bishop-Wisecarver  2,274.99     2,274.99   9829
    Linear Motion System                                                       Corp.
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      46
<PAGE>

<TABLE>
<S> <C>                   <C> <C>       <C>           <C>        <C>            <C>                <C>         <C>          <C>
------------------------------------------------------------------------------------------------------------------------------------
1   Vacuum Oven Model     TK  982146    N0030523      037880A                   Melles Groit        1,645.05    1,645.05    9776
    285A
-----------------------------------------------------------------------------------------------------------------------------------
1   Stereo MicroScope -   FL  982202    024339        M996458                   George S.           8,553.80    8,553.80    9558
    MZ8 High Resolution                                                         Maier Co.
-----------------------------------------------------------------------------------------------------------------------------------
1   PC Based Ready Key    BW  982203    3684                                    The Protection     33,219.86   33,219.86    10318
    Alarm System                                                                Bureau
-----------------------------------------------------------------------------------------------------------------------------------
1   Freezer, Ultra Low    BG  982215    3965158       13989232                  Fisher              6,521.35    6,521.35    9953
    25 Cubic Ft
-----------------------------------------------------------------------------------------------------------------------------------
1   Centra CL3R           BG  982215    3988532       537548                    Fisher              3,667.05    3,667.05    9953
    Centrifuge
-----------------------------------------------------------------------------------------------------------------------------------
1   Invaritar C5          CI  982216    278404081498  13262285A                 Fisher              1,808.27    1,808.27    9712
    Telecentric Lens
    System
--------------------------------------------------------------------------------------------------------------------------------
1   Replacement Laser     SE  982313    18947         97-200R    960.00         Kratos              5,500.00    5,500.00    9721
    for Mass Spec                                                               Analytical
----------------------------------------------------------------------------------------------------------------------------------
1   Isotemp Flammable     NS  982349    4726367       13988425D                 Fisher              2,440.88    2,440.88    10285
    Storage Freezer
----------------------------------------------------------------------------------------------------------------------------------
1   Laboratory Table      CM  982371    6244                                    LF Systems          1,388.00    1,388.00    10505
                                                                                Corp.
----------------------------------------------------------------------------------------------------------------------------------
1   Hydra 96 FlexChem     ZW  982508    10093679      029-81-1   MD987121020    Robbins            22,406.90   22,406.90    10246
    Station                                                                     Scientific
                                                                                Corp.
----------------------------------------------------------------------------------------------------------------------------------
1   Rotary Evaporator,    KW  982536    4278366       954711                    Fisher              3,633.00    3,633.00    10117
    Assembly C
----------------------------------------------------------------------------------------------------------------------------------
1   Innova Heating        ZW  982541    209449        M1192-0004 890614963      New Brunswick       5,241.98    5,241.98    9966
    Shaker Model 4080                                                           Scientific
                                                                                Corp.
----------------------------------------------------------------------------------------------------------------------------------
1   Innova Heating        ZW  982541    209449        M1192-0004 890614964      New Brunswick       5,241.98    5,241.98    9966
    Shaker Model 4080                                                           Scientific
                                                                                Corp.
----------------------------------------------------------------------------------------------------------------------------------
1   Thermal Cycler        JK  982549    2411779       2049900                   Techne Inc.         2,132.00    2,132.00    9921
----------------------------------------------------------------------------------------------------------------------------------
1   Cooled CCD Camera     JK  982550    IN-980918                               BioVision          14,419.00   14,419.00    9963
    w/Control Software                                                          Technologies
----------------------------------------------------------------------------------------------------------------------------------
3   (3) Non Cooled CCD    JK  982550    IN-980918                               BioVision           1,077.00    1,077.00    9963
    Camera                                                                      Technologies
----------------------------------------------------------------------------------------------------------------------------------
1   Stainless Steel       FL  982713    6270                                    LF Systems          2,990.00    2,990.00    10204
    Table                                                                       Corp.
----------------------------------------------------------------------------------------------------------------------------------
2   (2) Centrifuge 5415C  KJM 982814    4566010       540010                    Fisher              1,676.12    3,352.24    10285
----------------------------------------------------------------------------------------------------------------------------------
2   (2) Power Supply      KLM 982814    4566010       FB5090                    Fisher              1,498.50    2,997.00    10285
    2000V
----------------------------------------------------------------------------------------------------------------------------------
1   (6) Faucets           BW  982968    6297          L-2714     LVB            LF Systems          1,348.00    1,348.00    10319
                                                                                Corp.
----------------------------------------------------------------------------------------------------------------------------------
1   Turbomolecular        SE  983034    566777        B72201000   986040145     BOC Edwards         3,176.91    3,176.91    10020
    Pump, EXT70                                                                 (Edwards High
                                                                                Vac.)
----------------------------------------------------------------------------------------------------------------------------------
1   Rotary Evaporator     WP  983274    5048115       954741                    Fisher              4,242.00    4,242.00    10323
    24/40
----------------------------------------------------------------------------------------------------------------------------------
1   Impact 2-12 Channel   GP  983453    81175         2011                      Matrix              1,288.35    1,288.35    10320
    12Sul Pipe                                                                  Technologies
                                                                                Corp.
----------------------------------------------------------------------------------------------------------------------------------
1   Roof Top Condensor    BW  983628    16837                                   Jordon Scientific   2,590.00    2,590.00    10322
                                                                                                               ---------
    Unit                                                                        Products
----------------------------------------------------------------------------------------------------------------------------------
                                                                  Laboratory Equipment Total                  252,006.50
----------------------------------------------------------------------------------------------------------------------------------
1   Refrigerated          BW   940140    8049                     17424094H     Jordon              1,139.09    1,139.09    10321
    Incubator                                                                   Commercial
                                                                                Refrigerator
----------------------------------------------------------------------------------------------------------------------------------
1   Renaissance Gravity   BR   940303    4219895    RE21-103      R812109401    Amsco Sterilizer    4,891.05    4,891.05    10321
    Sterilizer                                      -0134                       Company
----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      47
<PAGE>

<TABLE>
<S> <C>                   <C> <C>       <C>        <C>         <C>            <C>               <C>          <C>          <C>
--------------------------------------------------------------------------------------------------------------------------------
1   Kompact Maldi III     BR  940355    114994                 0074/01        Schmadzu          26,922.31    26,922.31    10321
    Mass Spec                                                                 Scientific
                                                                              Instruments
--------------------------------------------------------------------------------------------------------------------------------
1   Autosampler           RH  940356    17761      080-0411    0432-047       Hitachi           1,896.31     1,896.31     10321
                                                                              Instruments
--------------------------------------------------------------------------------------------------------------------------------
1   AS4000 Autosampler    RH  940356    177829     080-0411    0463-016       Hitachi           2,014.83     2,014.83     10321
                                                                              Instruments
--------------------------------------------------------------------------------------------------------------------------------
1   Fluoroscence          RH  940356    177829     050-0825    0609-033       Hitachi           1,848.47     1,848.47     10321
    Detector                                                                  Instruments
--------------------------------------------------------------------------------------------------------------------------------
1   HPLC Manager          RH  940356    177829     ANO-0800    0650-004       Hitachi           563.62       563.62       10321
    Software                                                                  Instruments
--------------------------------------------------------------------------------------------------------------------------------
1   PCIA Interface        RH  940358    177829     ANO-0146    173112         Hitachi           128.47       128.47       10321
                                                                              Instruments
--------------------------------------------------------------------------------------------------------------------------------
1   Biological Safety     BR  940459    32988                  61183          Nuaire, Inc.      974.90       974.90       10321
    Cabinet
--------------------------------------------------------------------------------------------------------------------------------
1   G25 Shaking           ID  940582    6251375    1427885     490940588      New Brunswick     1,092.77     1,092.77     10321
    Incubator                                                                 - Fisher
--------------------------------------------------------------------------------------------------------------------------------
1   Blacore System        MP  940608    40565790               33-549-0441    Pharmacia Biotech 22,252.98    22,252.98    10321
                                                                                                             ---------
--------------------------------------------------------------------------------------------------------------------------------
                                                               Comdisco Buyout - Laboratory Equipment Total  63,714.79
                                                                                                             ---------
--------------------------------------------------------------------------------------------------------------------------------
                                                               Lab Equipment & Comdisco Buyout Sub-Total     315,721.29
                                                                                                             ----------
--------------------------------------------------------------------------------------------------------------------------------
                                                                                                   Total     422,217.54
                                                                                                             ----------
--------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      48
<PAGE>

                           PAYMENT ADJUSTMENT RIDER
                           ------------------------

     Rider to Schedule No. 03 to Master Loan and Security Agreement No. 7110
                           --
dated June 18, 1998 (the "CONTRACT") Between 3-Dimensional Pharmaceuticals, Inc.
      -------------                          -----------------------------------
as Borrower (the "OBLIGOR") AND PHOENIXCOR, INC. as Lender ("P.C.").

     1.   Purpose. This Rider sets forth the terms of adjustment of the payments
          -------
set forth in the Contract.

     2.   Definitions. The following terms shall have the following meanings
          -----------
herein:

          (a)  "Adjustment Date" shall mean the date P.C. disburses any portion
of the proceeds of the Contract.

          (b)  "Final T-Note Average" shall mean the average of the yields on
the U.S. Treasury Notes maturing in 4 years, as published by the Dow Jones
Telerate Access Service, Page 19901, for the close of business on each business
day of the two full calendar weeks immediately preceding the week containing the
Adjustment Date.

          (c)  "Preliminary Payments" shall mean the payments set forth in the
Contract, consisting or ($18,349.38 due upon execution followed by) 46
                        -----------
consecutive (monthly or quarterly) payments in the amount of $18,349.38
                                                             ----------
commencing 30 days after the Adjustment Date, following by one monthly payment
of $74,361.35.
   ----------

          (d)  "Preliminary T-Note Average" shall mean 5.41%.
                                                       -----

     3.   Adjustment of Payments. The Preliminary Payments were calculated based
          ----------------------
on a spread over the Preliminary T-Note Average. If the Adjustment Date occurs
after June 17, 1998 and the Final T-Note Average exceeds the Preliminary T-Note
Average, then the Preliminary Payments shall be revised. For each increase or
decrease of one (1) basis point (i.e., 1/100 of 1%) in the Final T-Note Average
above the Preliminary T-Note Average, the Preliminary Payments shall be revised
as follows (complete below as applicable):

 .    The $18,349.38 payment due upon execution shall remain unchanged.
         ----------

 .    Each of the 46 payments in the amount of $18,349.38 shall increase or
                 --                           ----------
     decrease by $3.81.
                 -----

Immediately after the determination of the revised payments due under the
Contract, Obligor shall, at the request of P.C. execute an acknowledgement
reflecting the revised payment schedule and, if requested by P.C. a Replacement
Contract containing the agreed to payments, but the failure of P.C. to make such
a request or the failure of Obligor to execute the acknowledgement or
Replacement Contract shall in no way diminish Obligor's obligations hereunder.

     4.   P.C.'s Requirements. The Commencement of the contract is subject to
satisfaction of all documentation and credit requirements of P.C. If such
requirements are not satisfied by the Adjustment Date, then at P.C.'s option,
the Adjustment Date shall be the date when such requirements are satisfied.

The calculation of the Contract Payments under this Rider will supersede any
prior proposal or quotation.

     IN WITNESS WHEREOF, the parties have executed this Rider simultaneously
with the Contract.

PHOENIXCOR, INC.                 3-Dimensional Pharmaceuticals, Inc.

By: _________________________    By: ________________________________________

Title: ______________________    Title: _____________________________________

                                      49
<PAGE>

                               PHOENIXCOR, INC.
                                65 WATER STREET
                            SOUTH NORWALK, CT 07854
                    203-855-0030 (PHONE) 203-866-3593 (FAX)

                                                               December 29, 1998
3-Dimensional Pharmaceuticals, Inc.
Eagleview Corporate Center, 665 Stockton Drive, suite 104
Exton, PA 19341

         Re:   Equipment Schedule #03

Ladies and Gentlemen:

Phoenixcor, Inc. requires insurance coverage with companies and in form
satisfactory to it as one of the conditions to enter into the above described
lease or loan with your Company covering the Equipment listed on the attached
schedule or exhibit. This insurance must be carried throughout the term of the
lease/loan. Please sign and return this letter. Please forward a copy of this
letter to your insurance company to process a certificate with the following
requirements:

PROPERTY COVERAGE:
-----------------
 .    Covering all risks of physical loss, damage, destruction or theft of the
     Equipment, with extended coverage.
 .    Loss payable to PHOENIXCOR, INC. AND ITS ASSIGNS.
 .    In an amount equal to not less than the Equipment's full replacement value
     of $743,612.54.
        -----------

LIABILITY COVERAGE:
------------------
 .    $2,000,000.00 combined single limit for each occurrence general liability
     -------------
     coverage.
 .    Naming PHOENIXCOR, INC. AND ITS ASSIGNS as Additional Insured

PROPERTY AND LIABILITY COVERAGE:
------------------------------
 .    The Equipment should be described specifically or by reference to an
     attached schedule or exhibit or by reference to the above lease or loan and
     account number.
 .    Carrier should be rated A-, VIII (or better) by A.M. Best Company.
 .    Notices to Phoenixcor, Inc. are to be sent to 65 water Street, South
     Norwalk, Connecticut 06854.

Attached is a sample insurance certificate. Additional provisions may be
required for vehicles or other specialized collateral or if otherwise applicable
to the transaction.

ADDITIONAL POLICY PROVISIONS:
----------------------------
 .    The policies must provide that they will not be canceled or altered without
     thirty (30) days prior written notice to PHOENIXCOR, INC.
 .    The policies insuring against loss, damage, destruction or theft must
     provide that the coverage will not be invalidated against PHOENIX, INC. AND
     ITS ASSIGNS because of any violation of any condition or warranty contained
     in any policy or application therefor by the insured or others.

Please feel free to contact or have your insurance agent contact Joan Kossoff at
your earliest convenience. Please be aware that failure to have an insurance
certificate in effect that meets the above requirements will delay the
commencement and/or funding of the above lease or loan.

Very truly yours,                       AGREED TO AND ACCEPTED BY;

PHOENIXCOR, INC.                        3 Dimensional Pharmaceuticals, Inc.

                                        BY: ____________________________________

                                        TITLE: _________________________________

                                      50
<PAGE>

Insurance Declarations Page

                                      51
<PAGE>

                SCHEDULE TO MASTER LOAN AND SECURITY AGREEMENT
                ----------------------------------------------

MASTER LOAN AND SECURITY AGREEMENT NO.7110             DATED: June 18, 1998
                                      ----                    -------------
SCHEDULE NO.04                                         DATED: March 22, 1999
            --                                                --------------

--------------------------------------------------------------------------------
LENDER:   PHOENIXCOR, INC.         BORROWER: 3-Dimensional Pharmaceuticals, Inc.
          65 WATER STREET                    Eagleview Corporate Center,
          SOUTH NORWALK, CT 06854            665 Stockton Drive, Suite 104
                                             Exton, PA 19341

Equipment Location (if other than above address of Borrower): n/a
                                                              ---

     Lender and Borrower have entered into a Master Loan and Security Agreement
No. 7110 dated June 18, 1998 (the "Master Loan Agreement") which is incorporated
    ----       -------------
herein and this is a Schedule to the Master Loan Agreement. All words and terms
used herein and not specifically defined herein shall have the same meanings as
set forth in the Master Loan Agreement.

     1.   THE LOAN AND LOAN REPAYMENT. As requested by Borrower and pursuant to
the Master Loan Agreement, Lender agrees to lend to Borrower the sum of one
                                                                        ---
million two hundred twenty-three thousand eight hundred eighty-three dollars and
--------------------------------------------------------------------------------
ninety-six cents. Borrower agrees to repay the Loan in successive installments
----------------
(which installment payments are inclusive of interest) as set forth in the
following Schedule:

                                   SCHEDULE
--------------------------------------------------------------------------------
Advance Payment Amount:                                  $9,611.30
                                                         ---------
Number of Installments (Exclusive of Advance Payment):   46
                                                         --
Payment Period:                                           X Monthly ___Quarterly
                                                         ---
Periodic Installment Payment Amount Per Period:          $9,611.30;
                                                         ---------
         Followed by One Monthly Installment Payment of  $38,950.00
                                                         ----------
--------------------------------------------------------------------------------
Commencement Date:  March 24, 1999                       Security Deposit (if
                    --------------
Special Provisions: (if any): none                       any): none
                              ----                             ----

     2.   SECURITY. As security for Borrower's obligations under this Schedule
and the obligations contained in the Master Loan Agreement, the Borrower gives
and grants to the Lender a security interest in the Equipment described in the
attached Exhibit A.

     3.   LOAN DISBURSEMENT. Borrower hereby authorizes Lender to disburse the
Loan proceeds advanced pursuant to this Schedule as follows:

          $389,500.00       To: Bruker Medical.
          -----------           ---------------
          $389,500.00       TOTAL PROCEEDS
          -----------

By execution hereof, the signer certifies that he/she is a duly authorized
officer, partner or proprietor of Borrower and that he/she had read, accepted
and duly executed this Schedule to the Master Loan Agreement on behalf of
Borrower.

                                 3-Dimensional Pharmaceuticals, Inc., (Borrower)
                                 -------------------------------------

                                 BY: _________________________________

                                 _____________________________________
                                 Print Name and Title

ACCEPTED AT LENDER'S OFFICE AT
SOUTH NORWALK, CONNECTICUT

PHOENIXCOR, INC. (Lender)

BY: ____________________________

________________________________
Print Name and Title

                                      52
<PAGE>

                                   EXHIBIT A

     The following description of property supplements, and is part, Schedule
No. 04 to Master Loan and Security Agreement No. 7110 dated June 18, 1998
    --                                           ----       -------------
between the undersigned Borrower and Phoenixcor, Inc. and may be attached to
said Loan Schedule and any related UCC Financing Statements, Acceptance or
Delivery Certificate or other document describing the property:

                   See Attached Exhibit A Equipment Schedule

All property listed above complete with any and all attachments, accessions,
additions, replacements, improvements, modifications and substitutions thereto
and therefor and all proceeds including insurance proceeds thereof and
therefrom.

PHOENIXCOR, INC.                        3-Dimensional Pharmaceuticals, Inc.
----------------                        -----------------------------------
(Lender)                                (Borrower)

BY: __________________________          By: _______________________________

TITLE: _______________________          TITLE: ____________________________

                                      53
<PAGE>

                        Exhibit A to Equipment Schedule
                                Schedule No. 04

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
      Company Name           3-Dimensional
                             Pharmaceutical, Inc.
-----------------------------------------------------------------------------------------------------------------------------------
      Equipment              665 Stickton Drive, Suite
      Location               104 Exton, PA 19341
-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
Item  Supplier        Equip  Description                 QTY  Serial No.  Price       Ext Price    Invoice      Vendor       PO#
                      Code                                                                         Subtotal     Subtotal
-----------------------------------------------------------------------------------------------------------------------------------
<S>   <C>             <C>    <C>                         <C>  <C>         <C>         <C>          <C>          <C>          <C>
1     Bruker Medical  LAB    Avencetem 400 High           1    BH028898   389,500.00  $389,500.00  $389,500.00  $389,500.00
      Inc.                   Performance Digital NMR
                             Spectrometer Maget/Shim
                             System
-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
                             TOTAL                                                                 $389,500.00  $389.500.00
-----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
---------------------------------------------------------------------------------------------------
      Company Name           3-Dimensional
                             Pharmaceutical, Inc.
---------------------------------------------------------------------------------------------------
      Equipment              665 Stickton Drive, Suite
      Location               104 Exton, PA 19341
---------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------
Item  Supplier        Equip  Description                     Invoice   Invoice     CK#   Ck Amt
                      Code                                   #         Date
---------------------------------------------------------------------------------------------------
<S>   <C>             <C>    <C>                             <C>       <C>         <C>   <C>
1     Bruker Medical  LAB    Avencetem 400 High              33949     1/18/99           Oz to Pay
      Inc.                   Performance Digital NMR
                             Spectrometer Maget/Shim
                             System
---------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------
                             TOTAL
---------------------------------------------------------------------------------------------------
</TABLE>

                                      54
<PAGE>

                           PAYMENT ADJUSTMENT RIDER
                           ------------------------

     Rider to Schedule No. 03 to Master Loan and Security Agreement No. 7110
                           --                                           ----
dated June 18, 1998 (the "CONTRACT") Between 3-Dimensional Pharmaceuticals, Inc.
      -------------                          -----------------------------
as Borrower (the "OBLIGOR") AND PHOENIXCOR, INC. as Lender ("P.C.").

     5.   Purpose. This Rider sets forth the terms of adjustment of the payments
          -------
set forth in the Contract.

     6.   Definitions. The following terms shall have the following meanings
          -----------
herein:

          (a)  "Adjustment Date" shall mean the date P.C. disburses any portion
of the proceeds of the Contract.

          (b)  "Final T-Note Average" shall mean the average of the yields on
the U.S. Treasury Notes maturing in 4 years, as published by the Dow Jones
Telerate Access Service, Page 19901, for the close of business on each business
day of the two full calendar weeks immediately preceding the week containing the
Adjustment Date.

          (c)  "Preliminary Payments" shall mean the payments set forth in the
Contract, consisting or ($9,611.30 due upon execution followed by) 46
                         ---------
consecutive (monthly or quarterly) payments in the amount of $9,611.30
                                                             ---------
commencing 30 days after the Adjustment Date, following by one monthly payment
of $38,950.00.
   ----------

          (d)  "Preliminary T-Note Average" shall mean 5.41%.
                                                       -----

     7.   Adjustment of Payments. The Preliminary Payments were calculated based
          ----------------------
on a spread over the Preliminary T-Note Average. If the Adjustment Date occurs
after June 17, 1998 and the Final T-Note Average exceeds the Preliminary T-Note
Average, then the Preliminary Payments shall be revised. For each increase or
decrease of one (1) basis point (i.e., 1/100 of 1%) in the Final T-Note Average
above the Preliminary T-Note Average, the Preliminary Payments shall be revised
as follows (complete below as applicable):

 .    The $9,611.30 payment due upon execution shall remain unchanged.
         ---------

 .    Each of the 46 payments in the amount of $9,611.30 shall increase or
                 --                           ---------
     decrease by $1.99.
                 -----

Immediately after the determination of the revised payments due under the
Contract, Obligor shall, at the request of P.C. execute an acknowledgement
reflecting the revised payment schedule and, if requested by P.C. a Replacement
Contract containing the agreed to payments, but the failure of P.C. to make such
a request or the failure of Obligor to execute the acknowledgement or
Replacement Contract shall in no way diminish Obligor's obligations hereunder.

     8.   P.C.'s Requirements. The Commencement of the contract is subject to
satisfaction of all documentation and credit requirements of P.C. If such
requirements are not satisfied by the Adjustment Date, then at P.C.'s option,
the Adjustment Date shall be the date when such requirements are satisfied.

The calculation of the Contract Payments under this Rider will supersede any
prior proposal or quotation.

     IN WITNESS WHEREOF, the parties have executed this Rider simultaneously
with the Contract.

PHOENIXCOR, INC.                        3-Dimensional Pharmaceuticals, Inc.

By: _______________________             By: _______________________________

Title: ____________________             Title: ____________________________

                                      55
<PAGE>

                SCHEDULE TO MASTER LOAN AND SECURITY AGREEMENT
                ----------------------------------------------

MASTER LOAN AND SECURITY AGREEMENT NO.7110              DATED: June 18, 1998
                                      ----                     -------------
SCHEDULE NO.03                                          DATED: December 29, 1998
            --                                                 -----------------

--------------------------------------------------------------------------------
LENDER:   PHOENIXCOR, INC.         BORROWER: 3-Dimensional Pharmaceuticals, Inc.
          65 WATER STREET                    Eagleview Corporate Center,
          SOUTH NORWALK, CT 06854            665 Stockton Drive, Suite 104
                                             Exton, PA 19341

Equipment Location (if other than above address of Borrower): n/a
                                                              ---

     Lender and Borrower have entered into a Master Loan and Security Agreement
No. 7110 dated June 18, 1998 (the "Master Loan Agreement") which is incorporated
    ----       -------------
herein and this is a Schedule to the Master Loan Agreement. All words and terms
used herein and not specifically defined herein shall have the same meanings as
set forth in the Master Loan Agreement.

     1.   THE LOAN AND LOAN REPAYMENT. As requested by Borrower and pursuant
to the Master Loan Agreement, Lender agrees to lend to Borrower the sum of seven
                                                                           -----
hundred forty-three thousand six hundred twelve and 54/100 dollars. Borrower
------------------------------------------------------------------
agrees to repay the Loan in successive installments (which installment payments
are inclusive of interest) as set forth in the following Schedule:

                                                          SCHEDULE
--------------------------------------------------------------------------------
Advance Payment Amount:                                  $18,349.38
                                                         ----------
Number of Installments (Exclusive of Advance Payment):   46
                                                         --
Payment Period:                                           X Monthly ___Quarterly
                                                         ---
Periodic Installment Payment Amount Per Period:          $18,349.38;
                                                         ----------
         Followed by One Monthly Installment Payment of  $74,361.25
                                                         ----------

--------------------------------------------------------------------------------
Commencement Date:  December 31, 1998                    Security Deposit (if
                    -----------------
Special Provisions: (if any): none                       any): none
                              ----                             ----

     2.   SECURITY. As security for Borrower's obligations under this Schedule
and the obligations contained in the Master Loan Agreement, the Borrower gives
and grants to the Lender a security interest in the Equipment described in the
attached Exhibit A.

     3.   LOAN DISBURSEMENT. Borrower hereby authorizes Lender to disburse the
Loan proceeds advanced pursuant to this Schedule as follows:

     $743,612.54    To: 3-Dimensional Pharmaceuticals, Inc.
     -----------        -----------------------------------
     $743,612.54    TOTAL PROCEEDS
     -----------

By execution hereof, the signer certifies that he/she is a duly authorized
officer, partner or proprietor of Borrower and that he/she had read, accepted
and duly executed this Schedule to the Master Loan Agreement on behalf of
Borrower.

                                      56
<PAGE>

<TABLE>
<S>                                    <C>
                                       3-Dimensional Pharmaceuticals, Inc., (Borrower)

                                        BY:________________________________________

                                        ___________________________________________
                                        Print Name and Title

ACCEPTED AT LENDER'S OFFICE AT
SOUTH NORWALK, CONNECTICUT

PHOENIXCOR, INC. (Lender)

BY:_________________________________

____________________________________
Print Name and Title
</TABLE>

                                      57<PAGE>

                                                                   EXHIBIT 10.26

                            MASTER LEASE AGREEMENT

Lessor:           TRANSAMERICA BUSINESS CREDIT CORPORATION
                  Riverway II
                  West Office Tower
                  West Higgins
                  Rosemont, Illinois  60018

Lessee:           3-DIMENSIONAL PHARMACEUTICALS, INC.
                  Eagleview Corporate Center
                  665 Stockton Drive, Suite 104
                  Exton, Pennsylvania  19341

         The lessor pursuant to this Master Lease Agreement ("Agreement") dated
as of June 12, 1997, is Transamerica Business Credit Corporation ("Lessor"). All
equipment, together with all present and future additions, parts, accessories,
attachments, substitutions, repairs, improvements, and replacements thereof or
thereto, which are the subject of a Lease (as defined in the next sentence)
shall be referred to as "Equipment." Simultaneous with the execution and
delivery of this Agreement, the parties are entering into one or more Lease
Schedules (each, a "Schedule") which refer to and incorporate by reference this
Agreement, each of which constitutes a lease (each, a "Lease") for the Equipment
specified therein. Additional details pertaining to each Lease are specified in
the applicable Schedule. Each Schedule that the parties hereafter enter into
shall constitute a Lease. Lessor has no obligation to enter into any additional
leases with, or extend any future financing to, Lessee.

               1. LEASE. Subject to an upon all of the terms and conditions of
                  -----
this Agreement and each Schedule, Lessor hereby agrees to lease to Lessee and
Lessee hereby agrees to lease from Lessor the Equipment for the Term (as defined
in Paragraph 2 below) thereof. The timing and financial scope of Lessor's
obligation to enter into Leases hereunder are limited as set forth in the
Commitment Letter executed by Lessor and Lessee, dated as of May 9, 1997 and
attached hereto as Exhibit A (the "Commitment Letter").

               2. TERM. Each Lease shall be effective and the term of each Lease
                  ----
("Term") shall commence on the commencement date specified in the applicable
Schedule and, unless sooner terminated (as hereinafter provided), shall expire
at the end of the term specified in such Schedule; provided, however, that
                                                   --------  -------
obligations due to be performed by Lessee during the Term shall continue until
they have been performed in full. Schedules will only be executed after the
delivery of the Equipment to Lessee or upon completion of deliveries of items of
such Equipment with aggregate cost of not less than $25,000.00.

               3. RENT. Lessee shall pay as rent to Lessor, for use of the
                  ----
Equipment during the Term or Renewal Term (as defined in Paragraph 8), rental
payments equal to the sum of all rental payments including, without limitation,
security deposits, advance rents, and interim rents payable in the amounts and
on the dates specified in the applicable Schedule ("Rent"). If any Rent or other
amount payable by Lessee is not paid within five days after the day on which it
<PAGE>

becomes payable, Lessee will pay on demand, as a late charge, an amount equal to
5% of such unpaid Rent or other amount but only to the extent permitted by
applicable law. All payments provided for herein shall be payable to Lessor at
its address specified above, or at any other place designated by Lessor.

               4. LEASE NOT CANCELABLE; LESSEE'S OBLIGATIONS ABSOLUTE. No Lease
                  ---------------------------------------------------
may be canceled or terminated except as expressly provided herein. Lessee's
obligation to pay all Rent due or to become due hereunder shall be absolute and
unconditional and shall not be subject to any delay, reduction, set-off,
defense, counterclaim, or recoupment for any reason whatsoever, including any
failure of the Equipment or any representations by the manufacturer or the
vendor thereof. If the Equipment is unsatisfactory for any reason, Lessee shall
make any claim solely against the manufacturer or the vendor thereof and shall,
nevertheless, pay Lessor all Rent payable hereunder.

               5. SELECTION AND USE OF EQUIPMENT. Lessee agrees that it shall be
                  ------------------------------
responsible for the selection and use of, and results obtained from, the
Equipment and any other associated equipment or services.

               6. WARRANTIES. LESSOR MAKES NO REPRESENTATION OR WARRANTY,
                  ----------
EXPRESS OR IMPLIED, AS TO ANY MATTER WHATSOEVER, INCLUDING, WITHOUT LIMITATION,
THE DESIGN OR CONDITION OF THE EQUIPMENT OR ITS MERCHANTABILITY, SUITABILITY,
QUALITY, OR FITNESS FOR A PARTICULAR PURPOSE, AND HEREBY DISCLAIMS ANY SUCH
WARRANTY. LESSEE SPECIFICALLY WAIVES ALL RIGHTS TO MAKE A CLAIM AGAINST LESSOR
FOR BREACH OF ANY WARRANTY WHATSOEVER. LESSEE LEASES THE EQUIPMENT "AS IS." IN
NO EVENT SHALL LESSOR HAVE ANY LIABILITY, NOR SHALL LESSEE HAVE ANY REMEDY
AGAINST LESSOR, FOR ANY LIABILITY, CLAIM, LOSS, DAMAGE, OR EXPENSE CAUSED
DIRECTLY OR INDIRECTLY BY THE EQUIPMENT OR ANY DEFICIENCY OR DEFECT THEREOF OR
THE OPERATION, MAINTENANCE, OR REPAIR THEREOF OR ANY CONSEQUENTIAL DAMAGES AS
THAT TERM IS USED IN SECTION 2-719(3) OF THE MODEL UNIFORM COMMERCIAL CODE, AS
AMENDED FROM TIME TO TIME ("UCC"). Lessor grants to Lessee, for the sole purpose
of prosecuting a claim, the benefits of any and all warranties made available by
the manufacturer or the vendor of the Equipment to the extent assignable.

               7. DELIVERY. Lessor hereby appoints Lessee as Lessor's agent for
                  --------
the sole and limited purpose of accepting delivery of the Equipment from each
vendor thereof. Lessee shall pay any and all delivery and installation charges.
Lessor shall not be liable to Lessee for any delay in, or failure or, delivery
of the Equipment.

               8. RENEWAL. So long as no Event of Default or event which, with
                  -------
the giving of notice, the passage of time, or both, would constitute an Event of
Default, shall have occurred and be continuing, or the Lessee shall not have
exercised its purchase option under Paragraph 9 hereof, each Lease will
automatically renew for a term of twelve months (the "Renewal Term") with the
monthly rent to be paid during such Renewal Term equal to 1.0% of the Equipment
Cost set forth on the applicable Schedule payable in advance; provided, however,
<PAGE>

that Obligations due to be performed by the Lessee during the Renewal Term shall
continue until they have been performed in full.

               9.  PURCHASE OPTION. So long as no Event of Default or event
                   ---------------
which, with the giving of notice, the passage of time, or both, would constitute
an Event of Default, shall have occurred and be continuing, Lessee may, upon
written notice to Lessor received at least ninety days before the expiration of
a Term, purchase all, but not less than all, the Equipment covered by the
applicable Lease on the date specified in the applicable Schedule ("Purchase
Date"). The purchase price for such Equipment shall be its fair market value,
which Lessor and Lessee agree shall be 10% of the Equipment Cost as set forth in
the applicable Schedule. Lessee shall pay the cost of any such appraisal. So
long as no Event of Default or event which, with the giving of notice, the
passage of time, or both, would constitute an Event of Default shall have
occurred and be continuing, Lessee may, upon written notice to Lessor received
at least ninety, but not more than one hundred eighty days prior to the
expiration of the Renewal Term, purchase all, but not less than all, the
Equipment covered by the applicable Schedule by the last date of the Renewal
Term (the "Alternative Purchase Date") at a purchase price equal to $1.00 on an
"In-place. In-use" basis. On the Purchase Date or the Alternative Purchase Date,
as the case may be, for any Equipment, Lessee shall pay to Lessor the purchase
price, together with all sales and other taxes applicable to the transfer of the
Equipment and any other amount payable and arising hereunder, in immediately
available funds, whereupon Lessor shall transfer to Lessee, without recourse or
warranty of any kind, express or implied, all of Lessor's right, title, and
interest in and to such Equipment on an "As Is, Where Is" basis.

               10. OWNERSHIP; INSPECTION; MARKING; FINANCING STATEMENTS. Lessee
                   ----------------------------------------------------
shall affix to the Equipment any labels supplied by Lessor indicating ownership
of such Equipment. The Equipment is and shall be the sole property of Lessor.
Lessee shall have no right, title, or interest therein, except as lessee under a
Lease. The Equipment is and shall at all times be and remain personal property
and shall not become a fixture. Lessee shall obtain and record such instruments
and take such steps as may be necessary to prevent any person from acquiring any
rights in the Equipment by reason of the Equipment being claimed or deemed to be
real property. Upon request by Lessor, Lessee shall obtain and deliver to Lessor
valid and effective waivers, in recordable form, by the owners, landlords, and
mortgagees of the real property upon which the Equipment is located or
certificates of Lessee that it is the owner of such real property or that such
real property is neither leased nor mortgaged. Lessee shall make the Equipment
and its maintenance records available for inspection by Lessor at reasonable
times and upon reasonable notice. Lessee shall execute and deliver to Lessor for
filing any UCC financing statements or similar documents Lessor may reasonably
request.

               11. EQUIPMENT USE. Lessee agrees that the Equipment will be
                   -------------
operated by competent. qualified personnel in connection with Lessee's business
for the purpose for which the Equipment was designed and in accordance with
applicable operating instructions, laws, and government regulations, and that
Lessee shall use all reasonable precautions to prevent loss or damage to the
Equipment from fire and other hazards. Lessee shall procure and maintain in
effect all orders, licenses, certificates, permits, approvals, and consents
required by federal, state, or local laws or by any governmental body, agency,
or authority in connection with the delivery, installation, use, and operation
of the Equipment.
<PAGE>

               12. MAINTENANCE. Lessee, at its sole cost and expense, shall keep
                   -----------
the Equipment in a suitable environment as specified by the manufacturer's
guidelines or the equivalent, shall meet all recertification requirements, and
shall maintain the Equipment in, good condition and working order, ordinary wear
and tear excepted. At the reasonable request of Lessor, Lessee shall furnish all
proof of maintenance.

               13. ALTERATION; MODIFICATIONS; PARTS. Lessee may materially alter
                   --------------------------------
or modify the Equipment only with the prior written consent of Lessor, which
consent shall not be unreasonably withheld. Any material alteration shall be
removed and the Equipment restored to its normal, unaltered condition at
Lessee's expense (without damaging the Equipment's originally intended function
or its value) prior to its return to Lessor. Any part installed in connection
with warranty or maintenance service or which cannot be removed in accordance
with the preceding sentence shall be the property of Lessor.

               14. RETURN OF EQUIPMENT. Except for Equipment that has suffered a
                   -------------------
Casualty Loss (as defined in Paragraph 15 below) and is not required to be
repaired pursuant to Paragraph 15 below or Equipment purchased by Lessee
pursuant to Paragraph 9 above, upon the expiration of the Renewal Term of a
Lease, or upon demand by Lessor pursuant to Paragraph 22 below, Lessee shall
contact Lessor for shipping instructions and, at Lessee's own risk, immediately
return the Equipment, freight prepaid, to a location in the continental United
States specified by Lessor. At the time of such return to Lessor, the Equipment
shall (i) be in the operating order, repair and condition as required by or
specified in the original specifications and warranties of each manufacturer and
vendor thereof, ordinary wear and tear excepted, (ii) meet all recertification
requirements, and (iii) be capable of being promptly assembled and operated by a
third party purchaser or third party lessee without further repair, replacement,
alterations, or improvements, and in accordance and compliance with any and all
statutes, laws, ordinances, rules, and regulations of any governmental authority
or any political subdivision thereof applicable to the use and operation of the
Equipment. Except as otherwise provided under Paragraph 9 hereof, at least
ninety days before the expiration of the Renewal Term, Lessee shall give Lessor
notice of its intent to return the Equipment at the end of such Renewal Term.
During the ninety-day period prior to the end of a Term or the Renewal Term,
Lessor and its prospective purchasers or lessees shall have, upon not less than
two business days' prior written notice to Lessee and during normal business
hours, or at any time and without prior notice upon the occurrence and
continuance of an Event of Default, the right of access to the premises on which
the Equipment is located to inspect the Equipment, and Lessee shall cooperate in
all other reasonable respects with Lessor's remarketing of the Equipment. The
provisions of this Paragraph 14 are of the essence of the Lease, and upon
application to any court of equity having jurisdiction in the premises, Lessor
shall be entitled to a decree against Lessee requiring specific performance of
the covenants of Lessee set forth in this Paragraph 14. If Lessee fails to
return the Equipment when required, the terms and conditions of the Lease shall
continue to be applicable and Lessee shall continue to pay Rent until the
Equipment is received by Lessor.

               15. CASUALTY INSURANCE: LOSS OR DAMAGE. Lessee will maintain, at
                   ----------------------------------
its own expense, liability and property damage insurance relating to the
Equipment, insuring against such risks as are customarily insured against on the
type of equipment leased hereunder by businesses in which Lessee is engaged in
such amounts, in such form, and with insurers satisfactory to Lessor; provided,
                                                                      --------
however, that the amount of insurance against damage or loss
-------
<PAGE>

shall not be less than the greater of (a) the replacement value of the Equipment
and (b) the stipulated loss value of the Equipment specified in the applicable
Schedule ("Stipulated Loss Value"). Each liability insurance policy shall
provide coverage (including, without limitation, personal injury coverage) of
not less than $1,000,000 for each occurrence, and shall name Lessor as an
additional insured; and each property damage policy shall name Lessor as sole
loss payee and all policies shall contain a clause requiring the insurer to give
Lessor at least thirty days' prior written notice of any alteration in the terms
or cancellation of the policy. Lessee shall furnish to Lessor a certificate of
insurance, and upon request, a copy of each insurance policy (with endorsements)
or other evidence satisfactory to Lessor that the required insurance coverage is
in effect; provided, however, Lessor shall have no duty to ascertain the
existence of or to examine the insurance policies to advise Lessee if the
insurance coverage does not comply with the requirements of this Paragraph. If
Lessee fails to insure the Equipment as required, Lessor shall have the right
but not the obligation to obtain such insurance, and the cost of the insurance
shall be for the account of Lessee due as part of the next due Rent. Lessee
consents to Lessor's release, upon its failure to obtain appropriate insurance
coverage, of any and all information necessary to obtain insurance with respect
to the Equipment or Lessor's interest therein.

               Until the Equipment is returned to and received by Lessor as
provided in Paragraph 14 above, Lessee shall bear the entire risk of theft or
destruction of, or damage to, the Equipment including, without limitation, any
condemnation, seizure, or requisition of title or use ("Casualty Loss"). No
Casualty Loss shall relieve Lessee from its obligations to pay Rent except as
provided in clause (b) below. When any Casualty Loss occurs, Lessee shall
immediately notify Lessor and, at the option of Lessee, shall promptly (a) place
such Equipment in good repair and working order; or (b) pay Lessor an amount
equal to the Stipulated Loss Value of such Equipment and all other amounts
(excluding Rent) payable by Lessee hereunder, together with a late charge on
such amounts at a rate per annum equal to the rate imputed in the Rent payments
hereunder (as reasonably determined by Lessor) from the date of the Casualty
Loss through the date of payment of such amounts, whereupon Lessor shall
transfer to Lessee, without recourse or warranty (express or implied), all of
Lessor's interest, if any. in and to such Equipment on an "AS IS, WHERE IS"
basis. The proceeds of any insurance payable with respect to the Equipment shall
be applied, at the option of Lessee, either towards (i) repair of the Equipment
or (ii) payment of any of Lessee's obligations hereunder. Lessee hereby appoints
Lessor as Lessee's attorney-in-fact to make claim for, receive payment of, and
execute and endorse all documents, checks or drafts issued with respect to any
Casualty Loss under any insurance policy relating to the Equipment.

               16. TAXES. Lessee shall pay when due, and indemnify and hold
                   -----
Lessor harmless from, all sales, use, excise, and other taxes, charges, and fees
(including, without limitation, income, franchise, business and occupation,
gross receipts, licensing, registration, titling, personal property, stamp and
interest equalization taxes, levies, imposts. duties, charges, or withholdings
of any nature), and any fines, penalties, or interest thereon, imposed or levied
by any governmental body, agency, or tax authority upon or in connection with
the Equipment, its purchase, ownership, delivery, leasing, possession, use, or
relocation of the Equipment or otherwise in connection with the transactions
contemplated by each Lease or the Rent thereunder, excluding taxes on or
measured by the net income of Lessor. Upon request, Lessee will provide proof of
payment. Unless Lessor elects otherwise, Lessor will pay all property taxes on
the Equipment for which Lessee shall reimburse Lessor promptly upon request.
Lessee shall
<PAGE>

timely prepare and file all reports and returns which are required to be made
with respect to any obligation of Lessee under this Paragraph 16. Lessee shall,
to the extent permitted by law, cause all billings of such fees, taxes, levies,
imposts, duties, withholdings, and governmental charges to be made to Lessor in
care of Lessee. Upon request, Lessee will provide Lessor with copies of all such
billings.

               17. LESSOR'S PAYMENT. If Lessee fails to perform its obligations
                   ----------------
under Paragraph 15 or 16 above, or Paragraph 23 below, Lessor shall have the
right to substitute performance, in which case Lessee shall immediately
reimburse Lessor therefor.

               18. GENERAL INDEMNITY. Each Lease is a net lease. Therefore,
                   -----------------
Lessee shall indemnify Lessor and its successors and assigns against, and hold
Lessor and its successors and assigns harmless from, any and all claims,
actions, damages, obligations, liabilities, and all costs and expenses,
including, without limitation, reasonable legal fees incurred by Lessor or its
successors and assigns arising out of each Lease including, without limitation,
the purchase, ownership, delivery, lease, possession, maintenance, condition,
use, or return of the Equipment, or arising by operation of law, except that
Lessee shall not be liable for any claims, actions, damages, obligations, and
costs and expenses determined by a non-appealable, final order of a court of
competent jurisdiction to have occurred as a result of the gross negligence or
willful misconduct of Lessor or its successors and assigns. Lessee agrees that
upon written notice by Lessor of the assertion of any claim, action, damage,
obligation or lien, Lessee shall assume full responsibility for the defense
thereof, provided that Lessor's failure to give such notice shall not limit or
otherwise affect its rights hereunder. Any payment pursuant to this Paragraph
(except for any payment of Rent) shall be of such amount as shall be necessary
so that, after payment of any taxes required to be paid thereon by Lessor,
excluding taxes on or measured by the net income of Lessor, the balance will
equal the amount due hereunder. The provisions of this Paragraph with regard to
matters arising during a Lease shall survive the expiration or termination of
such Lease.

               19. ASSIGNMENT BY LESSEE. Lessee shall not, without the prior
                   --------------------
written consent of Lessor, (a) assign, transfer, pledge, or otherwise dispose of
any Lease or Equipment, or any interest therein; (b) sublease or lend any
Equipment or permit it to be used by anyone other than Lessee, its agents and
its employees; or (c) move any Equipment from the location specified for it in
the applicable Schedule, except that Lessee may move Equipment to another
location within the United States provided that Lessee has delivered to Lessor
(A) prior written notice thereof and (B) duly executed financing statements and
other agreements and instruments (all in form and substance satisfactory to
Lessor) necessary or, in the opinion of the Lessor, desirable to protect
Lessor's interest in such Equipment. Notwithstanding anything to the contrary in
the immediately preceding sentence, Lessee may keep any Equipment consisting of
motor vehicles or rolling stock at any location in the United States.

               20. ASSIGNMENT BY LESSOR. Lessor may assign its interest or grant
                   --------------------
a security interest in any Lease and the Equipment individually or together, in
whole or in part. If Lessee is given written notice of any such assignment, it
shall immediately make all payments of Rent and other amounts hereunder directly
to such assignee. Each such assignee shall have all of the rights of Lessor
under each Lease assigned to it. Lessee shall not assert against any such
assignee any set-off, defense, or counterclaim that Lessee may have against
Lessor or any other person.
<PAGE>

               21. DEFAULT; NO WAIVER. Lessee or any guarantor of any or all of
                   ------------------
the obligations of Lessee hereunder (together with Lessee, the "Lease Parties")
shall be in default under each Lease upon the occurrence of any of the following
events (each, an "Event of Default"): (a) Lessee fails to pay within five days
of when due any amount required to be paid by Lessee under or in connection with
any Lease; (b) any of the Lease Parties fails to perform any other provision
under or in connection with a Lease or violates any of the covenants or
agreements of such Lease Party under or in connection with a Lease and such
failure or violation remains unremedied for fifteen days after the earlier of
the date on which Lessee knew of such failure or violation or the date on which
Lessor has given Lessee notice thereof: (c) any representation made or financial
information delivered or furnished by any of the Lease Parties under or in
connection with a Lease shall prove to have been inaccurate in any material
respect when made; (d) any of the Lease Parties makes an assignment for the
benefit of creditors, whether voluntary or involuntary, or consents to the
appointment of a trustee or receiver, or if either shall be appointed for any of
the Lease Parties or for a substantial part of its property without its consent
and, in the case of any such involuntary proceeding, such proceeding remains
undismissed or unstayed for sixty days following the commencement thereof; (e)
any petition or proceeding is filed by or against any of the Lease Parties under
any Federal or State bankruptcy or insolvency code or similar law and, in the
case of any such involuntary petition or proceeding, such petition or proceeding
remains undismissed or unstayed for sixty days following the filing or
commencement thereof, or any of the Lease Parties takes any action authorizing
any such petition or proceeding; (f) any of the Lease Parties fails to pay when
due any indebtedness for borrowed money or under conditional sales or
installment sales contracts or similar agreements, leases, or obligations
evidenced by bonds, debentures, notes, or other similar agreements or
instruments to any creditor (including Lessor under any other agreement) after
any and all applicable cure periods therefor shall have elapsed if the amount
involved exceeds $250,000 in the aggregate; (g) a judgment in excess of $50,000
shall be rendered against any of the Lease Parties which shall remain unpaid or
unstayed for a period of sixty days; (h) any of the Lease Parties shall
dissolve, liquidate, wind up or cease its business, sell or otherwise dispose of
all or substantially all of its assets, or make any material change in its lines
of business; (i) any of the Lease Parties shall amend or modify its name,
unless, within thirty days after such amendment or modification, such Lease Pam'
delivers to Lessor written notice of such amendment or modification and executed
financing statements (in form and substance satisfactory to the Lessor); (j) any
of the Lease Parties shall merge or consolidate with any other entity except
that any Lease Party may merge with or into any other entity so long as (i) the
survivor of such merger remains in compliance with the terms and conditions of
each Lease, and it' such survivor is not Lessee, then such survivor assumes ail
of the of Lessee under each Lease, including, without limitation, rental payment
obligations, pursuant to assignment and assumption documentation acceptable to
Lessor in its sole discretion, (ii) in the reasonable judgment of Lessor based
on, among other things, a review of all relevant financial statements of the
merging or consolidating Lease Parties, the ability of such survivor to perform
its obligations under each Lease is no worse than that of the non-surviving
entity immediately before such merger or consolidation and (iii) if applicable,
the surviving Lease Party delivers executed financing statement (in form and
substance satisfactory to Lessor); (k) any of the Lease Parties shall suffer any
loss or suspension of any material license, permit, or other right or asset
necessary to the profitable conduct of its business, fail generally to pay its
debts as they mature, or call a meeting for purposes of compromising its debts;
(l) any of the Lease Parties shall deny or disaffirm its

<PAGE>

obligations hereunder or under any of the documents delivered in connection
herewith; or (m) there is a change, other than a change which results from the
sale of newly issued securities to investors, in more than 35% of the ownership
of any equity interests of any of the Lease Parties on the date hereof or more
than 35% of such interests become subject to any contractual, judicial or
statutory lien, charge, security interest, or encumbrance.

               22. REMEDIES. Upon the occurrence and continuation of an Event of
                   --------
Default. Lessor shall have the right, in its sole discretion, to exercise any
one or more of the following remedies: (a) terminate each Lease; (b) declare any
and all Rent and other amount; then due and any and all Rent and other amounts
to become due under each Lease (collectively, the "Lease Obligations")
immediately due and payable; (c) take possession of any or all items of
Equipment, wherever located, without demand, notice, court order, or other
process of law, and without liability for entry to Lessee's premises, or
otherwise; (d) demand that Lessee immediately return any or all Equipment to
Lessor in accordance with Paragraph 14 above, and, for each day that Lessee
shall fail to return any item of Equipment, Lessor may demand an amount equal to
the Rent payable for such Equipment in accordance with Paragraph 14 above; (e)
lease, sell, or otherwise dispose of the Equipment in a commercially reasonable
manner, with or without notice and on public or private bid; (t) recover the
following amounts from the Lessee (as damages, including reimbursement of costs
and expenses, liquidated for all purposes and not as a penalty): (i) all costs
and expenses of Lessor reimbursable to it hereunder, including, without
limitation, expenses of disposition of the Equipment, legal fees, and all other
amounts specified in Paragraph 23 below; (ii) an amount equal to the sum of (A)
any accrued and unpaid Rent through the later of (1) the date of the applicable
default, (2) the date that Lessor has obtained possession of the Equipment, or
(3) such other date as Lessee has made an effective tender of possession of the
Equipment to Lessor (the "Default Date") and (B) if Lessor resells or re-lets
the Equipment, Rent at the periodic rate provided for in each Lease for the
additional period that it takes Lessor to resell or re-let all of the Equipment;
(iii) the present value of all future Rent reserved in the Leases and contracted
to be paid over the unexpired Term of the Leases discounted at five percent
compound interest; (iv) the reversionary value of the Equipment as of the
expiration of the Term of the applicable Lease as set forth on the applicable
Schedule; and (v) any indebtedness for Lessee's indemnity under Paragraph 18
above, plus a late charge at the rate specified in Paragraph 3 above, less the
amount received by Lessor, if any, upon sale or re-let of the Equipment; and (g)
exercise any other right or remedy to recover damages or enforce the terms of
the Leases. Upon the occurrence and continuance of an Event of Default or an
event which with the giving of notice or the passage of time, or both. would
result in an Event of Default, Lessor shall have the right, whether or not
Lessor has made any demand or the obligations of Lessee hereunder nave matured,
to appropriate and apply to the payment of the obligations of Lessee hereunder
all security deposits and other deposits (general or special, time or demand,
provisional or final) now or hereafter held by and other indebtedness or
property now or hereafter owing by Lessor to Lessee. Lessor may pursue any other
rights or remedies available at law or in equity, including, without limitation,
rights or remedies seeking damages, specific performance, and injunctive relief.
Any failure of Lessor to require strict performance by Lessee, or any waiver by
Lessor of any provision hereunder or under any Schedule, shall not be construed
as a consent or waiver of any other breach of the same or of any other
provision. Any amendment or waiver of any provision hereof or under any Schedule
or consent to any departure by Lessee herefrom or therefrom shall be in writing
and signed by Lessor.

<PAGE>

               No right or remedy is exclusive of any other provided herein or
permitted by law or equity. All such rights and remedies shall be cumulative and
may be enforced concurrently or individually from time to time.

               23. LESSOR'S EXPENSE. Lessee shall pay Lessor on demand all costs
                   ----------------
and expenses (including reasonable legal fees and expenses) incurred in
connection with the preparation, execution and delivery of this Agreement and
other agreement and transaction contemplated hereby, which expenses shall not
exceed $2,000 without the written consent of Lessee and all costs and expanses
in protecting and enforcing Lessors rights and interests in each Lease and the
Equipment, including, without limitation, legal, collection, and remarketing
fees and expenses incurred by Lessor in enforcing the terms, conditions, or
provisions of each Lease or upon the occurrence and continuation of an Event of
Default.

               24. LESSEE'S WAIVERS. To the extent permitted by applicable law,
                   ----------------
Lessee hereby waives any and all rights and remedies conferred upon a lessee by
Sections 2A-508 through 2A-522 of the UCC; provided, however, that Lessee shall
have the right to recover damages from Lessor for any breach by Lessor of its
obligations under this Agreement. To the extent permitted by applicable law,
Lessee also hereby waives any rights now or hereafter conferred by statute or
otherwise which may require Lessor to sell, lease, or otherwise use any
Equipment in mitigation of Lessor's damages as set forth in Paragraph 22 above
or which may otherwise limit or modify any of Lessor's rights or remedies under
Paragraph 22. Any action by Lessee against Lessor for any default by Lessor
under any Lease shall be commenced within one year after any such cause of
action accrues.

               25. NOTICES; ADMINISTRATION. Except as otherwise provided herein,
                   -----------------------
all notices, approvals, consents, correspondence, or other communications
required or desired to be given hereunder shall be given in writing and shall be
delivered by overnight courier, hand delivery, or certified or registered mail,
postage prepaid, if to Lessor, then to Transamerica Technology Finance Division,
76 Batterson Park Road, Farmington, Connecticut 06032, Attention: Assistant Vice
President, Lease Administration, with a copy to Lessor at Riverway II, West
Office Tower, 9399 West Higgins Road, Rosemont, Illinois 60018, Attention: Legal
Department, if to Lessee, then to 3-Dimensional Pharmaceuticals, Inc., Eagleview
Corporate Center, 665 Stockton Drive, Suite 104, Exton, Pennsylvania 19341,
Attention: Chief Financial Officer or such other address as shall be designated
by Lessee or Lessor to the other party. All such notices and correspondence
shall be effective when received.

               26. REPRESENTATIONS. Lessee represents and warrants to Lessor
                   ---------------
that (a) Lessee is duly organized, validly existing, and in good standing under
the laws of the State of its incorporation; (b) the execution, delivery, and
performance by Lessee of this Agreement are within Lessee's powers, have been
duly authorized by all necessary action, and do not and will not cause a
material violation of (i) Lessee's organizational documents or (ii) any known
law, regulation, rule, or contractual restriction binding on or affecting
Lessee; (c) no authorization or approval or other action by, and no notice to or
filing with, any governmental authority or regulatory body is required for the
due execution, delivery, and performance by Lessee of this Agreement; (d) each
Lease constitutes the legal, valid, and binding obligations of Lessee
enforceable against Lessee in accordance with its terms, limited by the effect
of applicable bankruptcy, insolvency, reorganization or similar laws affecting
the enforcement of creditors'
<PAGE>

rights generally; (e) the cost of each item of Equipment does not exceed the
fair and usual price for such type of equipment purchased in like quantity and
reflects all discounts, rebates, and allowances for the Equipment (including,
without limitation, discounts for advertising, prompt payment, testing, or other
services) given to the Lessee by the manufacturer, supplier, or any other
person; and (f) all information supplied by Lessee to Lessor in connection
herewith is correct and does not omit any statement necessary to insure that the
information supplied is not materially misleading.

               27. FURTHER ASSURANCES. Lessee, upon the request of Lessor, will
                   ------------------
execute, acknowledge, record, or file, as the case may be, such further
documents and do such further acts as may be reasonably necessary, desirable, or
proper to carry out more effectively the purposes of this Agreement. Lessee
hereby appoints Lessor as its attorney-in-fact to execute on behalf of Lessee
and authorizes Lessor to file without Lessee's signature any UCC financing
statements and amendments Lessor deems advisable.

               28. FINANCIAL STATEMENTS. Lessee shall deliver to Lessor: (a) as
                   --------------------
soon as available, but not later than 120 days after the end of each fiscal year
of Lessee and its consolidated subsidiaries, the consolidated balance sheet,
income statement, and statements of cash flows and shareholders equity for
Lessee and its consolidated subsidiaries (the "Financial Statements") for such
year, reported on by independent certified public accountants without an adverse
qualification; and (b) as soon as available, but not later than 60 days after
the end of each of the first three fiscal quarters in any fiscal year of Lessee
and its consolidated subsidiaries, the Financial Statements for such fiscal
quarter together with a certification duly executed by a responsible officer of
Lessee that such Financial Statements have been prepared in accordance with
generally accepted accounting principles and are fairly stated in all material
respects (subject to normal year-end audit adjustments). Lessee shall also
deliver to Lessor as soon as available copies of all press releases and other
similar communications issued by Lessee.

               29. CONSENT TO JURISDICTION. Lessee irrevocably submits to the
                   -----------------------
Jurisdiction of any Illinois state or federal court sitting in Illinois for any
action or proceeding arising out of or relating to this Agreement or the
transactions contemplated hereby, and Lessee irrevocably agrees that all claims
in respect of any such action or proceeding may be heard and determined in such
Illinois state or federal court.

               30. WAIVER OF JURY TRIAL, LESSEE AND LESSOR IRREVOCABLY WAIVE ALL
RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING, OR COUNTERCLAIM ARISING OUT OF
OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.

               31. FINANCE LEASE. Lessee and Lessor agree that each Lease is a
                   -------------
"Finance Lease" as defined by Section 2A-103(g) of the UCC. Lessee acknowledges
that Lessee has reviewed and approved each written Supply Contract (as defined
by UCC 2A-l03(y)) covering Equipment purchased from each "Supplier" (as defined
by UCC 2A-l03(x)) thereof.

               32. NO AGENCY. Lessee acknowledges and agrees that neither the
                   ---------
manufacturer or supplier, nor any salesman, representative, or other agent of
the manufacturer or supplier, is an agent of Lessor, No salesman,
representative, or agent of the manufacturer or

<PAGE>

supplier is authorized to waive or alter any term or condition of this Agreement
or any Schedule and no representation as to the Equipment or any other matter by
the manufacturer or supplier shall in any way affect Lessee's duty to pay Rent
and perform its other obligations as set forth in this Agreement or any
Schedule.

               33. SPECIAL TAX INDEMNIFICATION. Lessee acknowledges that Lessor,
                   ---------------------------
in determining the Rent due hereunder, has assumed that certain tax benefits as
are provided to an owner of property under the Internal Revenue Code of 1986. as
amended (the "Code"), and under applicable state tax law, including, without
limitation, depreciation deductions under Section 168(b) of the Code, and
deductions under Section 163 of the Code in an amount at least equal to the
amount of interest paid or accrued by Lessor with respect to any indebtedness
incurred by Lessor in financing its purchase of the Equipment. are available to
Lessor as a result of the lease of the Equipment. In the event Lessor is unable
to obtain such tax benefits solely as a result of an act or omission of Lessee,
is required to include in income any amount other than the Rent, or is required
to recognize income in respect of the Rent earlier than anticipated pursuant to
this Agreement. Lessee shall pay Lessor additional rent ("Additional Rent") in a
lump sum in an amount needed to provide Lessor with the same after-tax yield and
after-tax cash flow as would have been realized by Lessor had Lessor (i) been
able to obtain such tax benefits, (ii) not been required to include any amount
in income other than the Rent, and (iii) not been required to recognize income
in respect of the Rent earlier than anticipated pursuant to this Agreement. The
Additional Rent shall be computed by Lessor, which computation shall be binding
on Lessee absent manifest error. Lessor shall provide Lessee with evidence of
the calculation of such Additional Rent. The Additional Rent shall be due
immediately upon written notice by Lessor to Lessee of Lessor's inability to
obtain tax benefits, the inclusion of any amount in income other than the Rent
or the recognition of income in respect of the Rent earlier than anticipated
pursuant to this Agreement. The provisions of this Paragraph 33 shall survive
the termination of this Agreement.

               34. GOVERNING LAW; SEVERABILITY. EACH LEASE SHALL BE GOVERNED BY
                   ---------------------------
THE LAWS OF THE STATE OF ILLINOIS WITHOUT GIVING EFFECT TO THE CONFLICT OF LAW
PRINCIPLES THEREOF. IF ANY PROVISION SHALL BE HELD TO BE INVALID OR
UNENFORCEABLE, THE VALIDITY AND ENFORCEABILITY OF THE REMAINING PROVISIONS SHALL
NOT IN ANY WAY BE AFFECTED OR IMPAIRED.

LESSEE ACKNOWLEDGES THAT LESSEE HAS READ THIS AGREEMENT AND THE SCHEDULE HERETO.
UNDERSTANDS THEM, AND AGREES TO BE BOUND BY THEIR TERMS AND CONDITIONS. FURTHER,
LESSEE AND LESSOR AGREE THAT THIS AGREEMENT. THE SCHEDULES DELIVERED IN
CONNECTION HEREWITH FROM TIME TO TIME. AND THE COMMITMENT LETTER ARE THE
COMPLETE AND EXCLUSIVE STATEMENT OF THE AGREEMENT BETWEEN THE PARTIES.
SUPERSEDING ALL PROPOSALS OR PRIOR AGREEMENTS, ORAL OR WRITTEN, AND ALL OTHER
COMMUNICATIONS BETWEEN THE PARTIES RELATING TO THE SUBJECT MATTER HEREOF. SHOULD
THERE EXIST ANY INCONSISTENCY BETWEEN THE TERMS OF THE COMMITMENT LETTER AND
THIS AGREEMENT, THE TERMS OF THIS AGREEMENT SHALL PREVAIL.
<PAGE>

               IN WITNESS WHEREOF, the parties hereto have executed or caused
this Agreement to be duly executed by their duly authorized officers as of the
date first written above.

                                     3-DIMENSIONAL PHARMACEUTICALS, INC.

                                     By: /s/ Scott Horvitz
                                        ----------------------------------------
                                        Name: Scott Horvitz
                                        Title: VP & CFO
                                        Federal Identification Number 23-2716487

                                     TRANSAMERICAN BUSINESS CREDIT CORPORATION

                                     By: /s/ Gary P. Moro
                                        ----------------------------------------
                                        Name: Gary P. Moro
                                        Title: Vice President
                                        Federal Identification Number 23-2716487
<PAGE>

May 9, 1997

                                    Revised

Mr. Scott M. Horvitz
Chief Financial Officer
3-Dimensional Pharmaceuticals, Inc.
Eagleview Corporate Center
665 Stockton Drive. Suite 104
Exton, Pennsylvania 19341

Dear Scott:

     Transamerica Business Credit Corporation - Technology Finance Division
("Lessors") is pleased to offer this commitment (the "Commitment") to lease the
Equipment described below to 3-Dimensional Pharmaceuticals, Inc. ("Lessee").
This Commitment supersedes all prior correspondence. proposals, and oral or
other communications relating to leasing arrangements between Lessee and Lessor.
The outline of this offer is as follows:

Lessee:                            3-Dimensional Pharmaceuticals, Inc.
------
Lessor:                            Transamerica Business Credit Corporation -
------                             Technology Finance Division and/or its
                                   affiliates, successors and assigns.

Guarantor:                         None.
---------
Equipment:                         Laboratory and Office Equipment (all
---------                          equipment subject to Lessor's approval prior
                                   to funding), and will also include, without
                                   limitation, all additions, improvements.
                                   replacements. repairs, appurtenances,
                                   substitutions, and attachments thereto and
                                   all proceeds thereof ("Equipment") and Tenant
                                   Improvements.
Equipment Cost:                    Not to exceed $1,000,000 with Tenant
--------------                     Improvements up to $300,000.
Equipment Location:                Exton, Pennsylvania
------------------
Anticipated Delivery:              Through June 30, 1998.
--------------------
Termination of Commitment:         This commitment will terminate if the first
-------------------------          delivery of Equipment is not completed and
                                   funded on or before June 15, 1997.
Lease Term                         Upon delivery of the Equipment or upon each
----------                         completion of deliveries of items of
Commitment:                        Equipment with aggregate cost of not less
----------                         than $25,000, but in no event shall any
                                   Equipment be delivered later than June 30,
                                   1998.
<PAGE>

Term:                              From each Lease Term Commencement until 48
----                               months from the first day of the month next
                                   following or on the same date as the Lease
                                   Term Commencement if that date is the first
                                   date of the month.
Lease Repayment Terms:             Monthly Rent equal to 2.5226% of Equipment
---------------------              Cost shall be payable monthly, in advance,
                                   plus applicable sales and other taxes. The
                                   first and last months rent shall be payable
                                   in advance. As of the date of each Lease Term
                                   Commencement, the Monthly Rent Payments shall
                                   be fixed for the term.

                                   The Lessor reserves the right to increase the
                                   Monthly Rent Payments as of the date of each
                                   Lease Term Commencement commensurate to the
                                   increase in the weekly average of the
                                   interest rates of three-year U.S. Treasury
                                   Securities from the week ending March 28,
                                   1997 to the week preceding the date of each
                                   Lease Term Commencement, as published in the
                                   Wall Street Journal.
Interim Rent Payments:             In the event that the Lease Term Commencement
---------------------              is not on the first day of the month, Interim
                                   Rent Payments shall accrue from each Lease
                                   Term Commencement until the next following
                                   first day of a month and shall be payable at
                                   the end of that month. Interim Rent Payments
                                   shall be calculated at the daily equivalent
                                   of the currently adjusted Monthly Payment.
Purchase Option:                   The Lessee shall have the option to purchase
---------------                    all (but not less than all) the Equipment at
                                   the expiration of the term of the lease for
                                   the then current Fair Market Value of the
                                   Equipment. Plus applicable sales and other
                                   taxes.

                                   It shall be agreed that the Fair Market Value
                                   will be 10% of Equipment Cost and Tenant
                                   Improvements, plus applicable sales and other
                                   taxes.
Automatic Renewal:                 In the event the Lessee does not exercise the
-----------------                  Purchase Option described above, the lease
                                   shall automatically renew for a term of
                                   twelve months with Monthly Rental equal to
                                   1.0% of the original Equipment Cost payable
                                   monthly in advance. At the expiration of the
                                   renewal period, the Lessee shall have the
                                   option to purchase all (but not less than
                                   all) of the Equipment for $1.00, plus
                                   applicable sales and other taxes.
Documentation:                     The documentation relating to this
-------------                      transaction shall implement the transaction
                                   contemplated by this commitment letter to the
                                   satisfaction of Lessor and its counsel, shall
                                   be fully acceptable to Lessor and its
                                   counsel, and shall contain conditions
                                   precedent,
<PAGE>

                                   representations, warranties and covenants by
                                   Lessee and shall provide for events of
                                   defaults and remedies, all as required by
                                   Lessor for transactions of this type. The
                                   documentation shall include, but not be
                                   limited to, the terms and conditions
                                   described in this commitment letter.
Insurance:                         Prior to any delivery of Equipment, the
---------                          Lessee shall furnish a certificate of
                                   insurance acceptable to the Lessor in amount,
                                   type. and term covering the Equipment
                                   including primary, all risk, physical damage,
                                   property damage and bodily injury with
                                   appropriate loss payee and additional insured
                                   endorsements in favor of the Lessor.
Taxes:                             Sales or use taxes would be added to the
-----                              Equipment Cost or collected on the gross
                                   rentals, as appropriate.
Representations and                There shall be no actual or threatened
-------------------                conflict with, or violation of. any
Additional Covenants:              regulatory statute. standard or rule relating
--------------------               to the Lessee, its present or future
                                   operations, or the Equipment.

                                   All information supplied by the Lessee shall
                                   be correct and shall not omit any statement
                                   necessary to make the information supplied
                                   not be materially misleading. There shall be
                                   no material breach of the representations and
                                   warranties of the Lessee in the Lease. The
                                   representations shall include that the
                                   Equipment Cost of each item of the Equipment
                                   does not exceed the fair and usual price for
                                   such type of Equipment purchased in like
                                   quantity purchased of such item and reflects
                                   all discounts, rebates and allowances for the
                                   Equipment given to Lessee by the
                                   manufacturer, supplier or any other person
                                   including, without limitation, discounts for
                                   advertising, prompt payment, testing or other
                                   services. There shall be no additional
                                   affirmative or negative financial covenants
                                   for this financing.
Conditions Precedent to            1.   No material adverse change in the
-----------------------                 financial condition, operation or
Each Lease Term                         prospects of the Lessee prior to
---------------                         funding. The Lessor reserves its right
Commencement:                           to rescind any unused portion of its
------------                            commitment in the event of a material
                                        adverse change in the financial or
                                        business condition of the Lessee.
                                   2.   Completion of the documentation and
                                        final terms of the proposed financing
                                        satisfactory to Lessor and Lessor's
                                        counsel.
                                   3.   Results of all due diligence, including
                                        lien, judgment and tax searches and
                                        other matters Lessor may request shall
                                        be satisfactory to Lessor and Lessor's
                                        counsel.
<PAGE>

                                   4.   Receipt by Lessor of duly executed Lease
                                        documentation in form and substance
                                        satisfactory to Lessor and its counsel.
                                   5.   Lessor shall receive title and a valid
                                        and perfected first priority lien and
                                        security interest in all Equipment
                                        acquired through the use of this
                                        Commitment and Lessor shall have
                                        received satisfactory evidence that
                                        there are no liens on any Equipment
                                        except as expressly permitted herein.
                                   6.   In consideration of the Lessor providing
                                        a Commitment to the Lessee to lease
                                        equipment under the terms herein, Lessor
                                        shall be granted Warrants to purchase
                                        shares of the common stock of the
                                        Lessee. The aggregate exercise price for
                                        the shares represented by the Warrants
                                        would be 10.5% of the commitment for
                                        Tenant Improvements ($300,000) or
                                        $31,500, and the exercise price per
                                        share shall be $2.50 per share if the
                                        Lessee sells shares in an "arms length"
                                        transaction (including a Corporate
                                        Partnership) of its equity securities at
                                        or above that price on or before June
                                        30, 1997; otherwise the exercise price
                                        shall be $1.25 per share. The Warrants
                                        shall be exercisable from the date of
                                        issuance and have a term of seven years.
                                        Lessor may retain or transfer Warrants
                                        (subject to compliance with applicable
                                        securities laws) or the shares issuable
                                        thereunder, in whole or in part, whether
                                        or not Lessor sells its rights under any
                                        Lease an/or its ownership of equipment
                                        to another Lessor or any participation
                                        therein.
                                   7.   Satisfactory review by Lessor's
                                        Scientific Advisory Board prior to
                                        funding.
                                   8.   Satisfactory review by Lessor of the
                                        1996 audited financial statements prior
                                        to funding.
                                   9.   Landlord Waiver in a form acceptable to
                                        Lessee and its landlord.
                                   10.  UCC-l Fixture Filing.
Fees and Expenses:                 The Lessee shall be responsible for the
-----------------                  Lessor's reasonable expenses (including legal
                                   expenses) in connection with the transaction.
                                   Such expenses shall be limited to $2,000
                                   without the prior written consent of Lessee.
Law:                               This letter and the proposed Lease are
---                                intended to be governed by and construed in
                                   accordance with Illinois law without regard
                                   to its conflict of law provisions.
Indemnity:                         Lessee agrees to indemnify and to hold
---------                          harmless Lessor,
<PAGE>

                                   and its officers, directors and employees
                                   against all claims, damages. liabilities and
                                   expenses which may be incurred by or asserted
                                   against arty such person in connection with
                                   or arising our of this letter and the
                                   transactions contemplated hereby. other than
                                   claims, damages, liability, and expense
                                   resulting from such person's gross negligence
                                   or misconduct.
Confidentiality:                   This letter is delivered to you with the
---------------                    understanding that neither it nor its
                                   substance shall be disclosed publicly or
                                   privately to any third person except those
                                   who are in a confidential relationship to you
                                   (such as your legal counsel and accountants),
                                   or where the same is required by law and then
                                   only on the basis that it not be further
                                   disclosed, which conditions the Lessee, its
                                   Guarantor and its agents agree to be bound by
                                   upon acceptance of this letter.

                                   Without limiting the generality of the
                                   foregoing, none of such persons shall use or
                                   refer to Lessor or to any affiliate name in
                                   any disclosures made in connection with any
                                   of the transactions without Lessor's prior
                                   written consent.
Conditions of Acceptance:          This Commitment Letter is intended to be a
------------------------           summary of the most important elements of the
                                   agreement to enter into a leasing transaction
                                   with Lessee, and it is subject to all
                                   requirements and conditions contained in
                                   Lease documentation proposed by Lessor or its
                                   counsel in the course of closing the lease
                                   described herein. Not every provision that
                                   imposes duties, obligations, burdens, or
                                   limitations on Lessee is contained herein,
                                   but shall be contained in the final Lease
                                   documentation satisfactory to Lessor and its
                                   counsel.

                                   EACH OF THE PARTIES HERETO IRREVOCABLY AND
                                   UNCONDITIONALLY WAIVES ALL RIGHT TO TRIAL BY
                                   JURY IN ANY SUIT, ACTION, PROCEEDING OR
                                   COUNTERCLAIM ARISING OUT OF OR RELATED TO
                                   THIS LETTER OR THE TRANSACTION DESCRIBED IN
                                   THIS LETTER.
Commitment Fee:                    A Commitment Fee equal to 1% of the total
--------------                     Equipment Cost and Tenant Improvements
                                   ($10,000) shall be due the Lessor upon
                                   acceptance of this Commitment. The $10,000
                                   Application Fee previously paid shall be
                                   applied toward the Commitment Fee. The
                                   Commitment Fee shall be first applied to the
                                   cost and expenses incurred by Lessor in
                                   connection with the transaction (subject to
                                   the
<PAGE>

                                   $2000 limit), and the remainder shall be
                                   applied to the second month's rent due under
                                   the Lease.
Commitment Expiration:             This Commitment shall expire on May 9, 1997,
---------------------              unless prior thereto either extended in
                                   writing by the Lessor or accepted as provided
                                   below by the Lessee.

     Should you have any questions, please call me. If you wish to accept this
Commitment, please so indicate by signing and returning the enclosed duplicate
copy of this letter to me by May 14, 1997.

                                      Yours truly,

                                      TRANSAMERICA BUSINESS CREDIT CORPORATION-
                                      TECHNOLOGY FINANCE DIVISION

                                      By: /s/ Gerald A. Michaud
                                          ------------------------------------
                                          Gerald A. Michaud
                                          Senior Vice President - Marketing

Accepted this 9th day of May, 1997

3-DIMENSIONAL PHARMACEUTICALS, INC.

By: /s/ Scott Horvitz
    --------------------------------
        Typed or Printed Name

Title: Vice President and CFO
      ------------------------------
<PAGE>

                            SECRETARY'S CERTIFICATE

          I, _____________________, hereby state that I am the duly elected,
acting and qualified Secretary of 3-Dimensional Pharmaceuticals, Inc., a
Delaware corporation (the "Company"), and that:

          (a)  Through a unanimous consent in lieu of a Board of Directors
meeting of the Company, proposed in accordance with its bylaws and the laws of
said State on the ____ day of ___________, 1997, signed by a quorum for the
transaction of business, the following resolutions were duly and regularly
adopted:

          RESOLVED, that the form, terms and provisions of all of the documents
and instruments executed by the Company with and/or in favor of Transamerica
Business Credit Corporation (the "Agreements"), and the transactions
contemplated thereby be, and the same are, in all respects approved, and that
the President, each Vice President and each other officer of the Company (the
"Authorized Persons"), or any of them, be, and they hereby are, authorized,
empowered, and directed to execute and deliver the Agreements and any and all
other agreements, documents, instruments and certificates required or desirable
in connection therewith, if necessary or advisable, with such changes as they
may deem in the best interest of the Company, and their execution and delivery
of the Agreements, and all such other agreements, documents, instruments and
certificates, shall be deemed to be conclusive evidence that the same are in all
respects authorized and approved; and be it further

          RESOLVED, that the actions of any Authorized Person heretofore taken
in furtherance of the Agreements be, and hereby are, approved, adopted and
ratified in all respects.

          (i)  The above resolutions: (a) are not contrary to the Articles or
Certificate of Incorporation or bylaws of the Company and (b) have not been
amended, modified, rescinded or revoked and are in full force and effect on the
date hereof.

          (ii) The following persons are duly qualified and acting officers of
the Company, duly elected to the offices set forth opposite their respective
names, and the signature appearing opposite the name of each such officer is his
authentic signature:

Name                       Office                        Signature
----                       ------                        ---------

Thomas P. Stagnaro         President and                 /s/ Thomas P. Stagnaro
                                                         ----------------------
                           Chief Executive Officer

Scott M. Horvitz           Vice President and            /s/ Scott m. Horvitz
                                                         --------------------
                           Chief Financial Officer
<PAGE>

          IN WITNESS WHEREOF, I have executed this Certificate, this 13th day of
June, 1997.

                                                /s/ Scott Horvitz
                                                -------------------------------
                                                                Secretary

[CORPORATE SEAL]
<PAGE>

July 8, 1997

Mr. Scott M. Horvitz
Chief Financial Officer
3-Dimensional Pharmaceuticals, Inc.
Eagleview Corporate Center
665 Stockton Drive. Suite 104
Exton, Pennsylvania 19341

Re:  Customer No.  1046-001

Dear Scott:

     We would like to thank you for choosing Transamerica Business Credit
Corporation (TBCC) - Technology Finance Division for your recent refinancing.
For your files, we have enclosed copies of the various documents executed by
your organization in connection with the above referenced transactions. These
documents have been executed by Transamerica and should be retained by you in a
safe place.

     Invoices will be sent to you on a monthly basis, with your payments due on
the first day of each month. The remittance ad-dress for payment is 9399 West
Higgins Road, Suite 600, Rosemont, Illinois 60018. Please indicate your customer
numbers on the face of your check.

     Please be advised that you are responsible for the appropriate property tax
filing. Proof of filing and payment of property tax should be provided to TBCC
annually. All future payments should be made on or before the due date indicated
on each invoice. Payments arriving after 5 days of the due date will be subject
to a 5% late charge. All remittances should be sent to the above mentioned
address.

     We appreciate having been given the opportunity to serve you and we look
forward to do so again, in the future. Should you have any questions on your
account, please contact our Lease Administration Department at 860-677-6466 and
we will be delighted to assist you.

Very truly yours,

Transamerica Business Credit Corporation

/s/ Laura Robbins

Laura Robbins
Lease Administrator

Enc.
<PAGE>

                          COLLATERAL ACCESS AGREEMENT
                   TRANSAMERICA BUSINESS CREDIT CORPORATION
                       9399 West Higgins Road, Suite 600
                           Rosemont, Illinois 60018

                                                                   June 17, 1997

The Hankin Group
717 Constitution Drive
Eagleview Corporate Center
P.O. Box 562
Exton, PA 19341
Attn: Mr. Jack Purcell

     Re:  3-Dimensional Pharmaceuticals, Inc.

Ladies and Gentlemen:

          We have been asked by 3-Dimensional Pharmaceuticals, Inc., a Delaware
corporation (the "Company") to finance certain equipment (the "Equipment"),
which will be located at the address identified on Schedule A (the "Premises").
The obligations of the Company to us will be secured by, among other things, the
Equipment. We understand that the Company leases the Premises from you pursuant
to a lease or is the owner of the Premises, which is subject to a lien in favor
of you pursuant to a mortgage (such lease or mortgage being referred to as the
"Agreement").

          In connection with the extensions of credit to be made to the Company,
Transamerica Business Credit Corporation, ("Transamerica") will be making
customary Uniform Commercial Code filings on behalf of Transamerica with respect
to the Equipment. In addition, we request your acknowledgment and cooperation
for preserving and enforcing Transamerica's security interests. To expedite the
consummation of the proposed financing, we would appreciate your execution of
this letter.

          To induce Transamerica to finance the Equipment, and for other good
and valuable consideration, you confirm and acknowledge the following matters to
us:

You will allow us, or our auditors or other designees, reasonable access to the
Premises to inspect the Equipment from time to time. In addition, so long as the
Agreement is in effect and the Company is not in default in its obligations
thereunder, upon our request, you will grant us and our designees access to the
Premises at reasonable times to show the Equipment to potential purchasers and
to remove the Equipment from the Premises.

In the event that the Company defaults in its obligations under the Agreement as
a result of which you elect to terminate the Company's rights to possession
under the Agreement, you will
<PAGE>

notify us in writing of this fact prior to your terminating or exercising
remedies under the Agreement and retaking possession of the Premises, to permit
us the opportunity within ten (10) business days after written notice from you
to us, to remove the Equipment. We will indemnify, defend and save you harmless
from all costs, expenses and damages suffered by you in connection with our
removal of the Equipment. The Equipment shall not include any item which is
within the meaning of the term "Trade Fixtures" as defined in Section 7(f)(ii)
of the Agreement. You hereby confirm and acknowledge to us that, except as to
Trade Fixtures, you do not and will not have any claim to or lien on any of the
Equipment, whether such Equipment constitutes fixtures or personal property.

          We would appreciate your confirming to us your agreement to the
foregoing provisions of this letter by signing and returning to us this letter
at our address shown above.

Very truly yours,

TRANSAMERICA BUSINESS CREDIT
  CORPORATION

By:  /s/ Gary P. Moro
   ------------------------------------
   Name:    Gary P. Moro
   Title:   Vice President - Credit

ACKNOWLEDGED AND AGREED:

By: /s/ Robert S. Hankin
   ------------------------------------
   Name: Robert S. Hankin
   Title. Partner
          The Hankin Group
<PAGE>

                                  SCHEDULE A

Equipment Locations:          Eagleview Corporate Center
                              665 Stockton Drive, Suite 104
                              Exton, Pennsylvania 19341
<PAGE>

                      SCHEDULE TO MASTER LEASE AGREEMENT

                           Dated as of July 1, 1997

                                Schedule No. 1

Lessor Name & Mailing Address               Lessee Name & Mailing Address
Transamerica Business Credit Corporation    3-Dimensional Pharmaceuticals, Inc.
Riverway II                                 Eagleview Corporate Center
West Office Tower                           665 Stockton Drive, Suite 104
9399 West Higgins Road                      Exton, Pennsylvania 1 19341
Rosemont, Illinois  60018

     Equipment Location (if different than Lessee's address above):

     This Schedule covers the following described equipment ("Equipment"):

            See Exhibit II attached hereto and made a part hereof.

     The Equipment is hereby leased pursuant to the provisions of the Master
Lease Agreement between the undersigned Lessee and Lessor dated June 12, 1997
(the "Master Lease"), the terms of which are incorporated herein by reference
thereto, plus the following additional terms, provisions, and modifications. The
Lessor reserves the right to adjust the monthly payments in accordance with the
Commitment Letter dated May 9, 1997, if the Lessor has not received this
Schedule and an Acceptance and Delivery Certificate executed by the Lessee
within five business days from the date first set forth above.

<TABLE>
<S>                                                                             <C>
1.   Term (Number of Months)                                                    48 months
2.   Equipment Cost                                                             $34,586.96
3.   Commencement Date                                                          July 1, 1997
4.   Rate Factor                                                                2.5226% of Equipment Cost
5.   Total Rents                                                                $41,880.00
6.   Advance Rents (first and last)                                             $1,745.00
7.   Monthly rental payments                                                    $872.50
       And the second such rental payments will be due on and subsequent        August 1, 1997
       rental payments will be due on the same day of each month thereafter

8.   Security Deposit                                                           None
9.   In addition to the monthly rental payments  provided for herein,           N O N E
     Lessee shall pay to Lessor, as interim rent, payable on the commencement
     date specified above, an amount equal to 1/30th of the monthly rental
     payment (including monthly sales/use tax) multiplied by the number of days
     from and including the commencement date through the end of the same
     calendar month
</TABLE>
<PAGE>

     Lessee hereby irrevocably authorizes Lessor to insert in this Schedule the
Commencement Date and the due date of the first rental payment.

     Except as expressly provided or modified hereby, all the terms and
provisions of the Master Lease Agreement shall remain in full force and effect.

     The Purchase Date shall be June 1, 2001.

     The Stipulated Loss Value of any items of Equipment shall be an amount
equal to the present value of all future Rent discounted at a rate of 8% per
annum plus the Reversionary Value.

     The Reversionary Value of any item of Equipment shall be 10% of Equipment
Cost.

TRANSAMERICA BUSINESS CREDIT            3-DIMENSIONAL PHARMACEUTICALS,
CORPORATION                             INC.
(Lessor)                                (Lessee)

By: /s/ Gary P. Moro                    By:/s/ Scott Horvitz
   --------------------------------        ----------------------------

Title:   Vice President                 Title: VP & CFO
      -----------------------------           -------------------------
<PAGE>

                                  EXHIBIT II

To:

____   Schedule to Master Lease Agreement     ____  Sale and Leaseback Agreement
____   UCC                                    ____  Bill of Sale
____   Collateral Access Agreement

                           Dated as of July 1, 1997

                                    Between

                   TRANSAMERICA BUSINESS CREDIT CORPORATION

Customer Name:                3-DIMENSIONAL PHARMACEUTICALS, INC.
Equipment Locations:          Eagleview Corporate Center
                              665 Stockton Drive, Suite 104
                              Exton, Pennsylvania 19341

     See Rider I to Schedule No. 1 attached hereto and made a part hereof.

Transamerica Business Credit Corporation    3-Dimensional Pharmaceuticals, Inc.
(Lessor)                                    (Lessee)

By: /s/ Gary P. Moro                        By:/s/ Scott Horvitz
   ----------------------------                -------------------------------
                                                    Scott Horvitz

Title:  Vice President                      Title:  Vice President and Chief
      -------------------------                     Financial Officer
<PAGE>

                                     RIDER I
                                TO SCHEDULE NO. 1

                       3Dimensional Pharmaceuticals, inc.
                        Equipment Sale Leaseback Schedule
                                  June 17, 1998

<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------------------------
QTY        EQUIPMENT                      PURCHASE          INVOICE NO.         CATALOG       SERIAL NO.
          DESCRIPTION                       ORDER                                 NO.
---------------------------------------------------------------------------------------------------------
<S>       <C>                             <C>               <C>                 <C>           <C>
---------------------------------------------------------------------------------------------------------
1         Vacuum Desiccaator Cabiner               970235   278404021597          8644               N/A
---------------------------------------------------------------------------------------------------------
                                        970235 Total
---------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------
1         32 MB 168 PIN EDO DIMM                   970513       A0177766        CHP 0396             N/A
---------------------------------------------------------------------------------------------------------
1         Ether FE 10/100 PCI                      970513       A0177766        DEC 1883             N/A
---------------------------------------------------------------------------------------------------------
1         4MB VRAM F/StarMax                       970513       A0177766        CHP 0430             N/A
---------------------------------------------------------------------------------------------------------
1         ViewSonic/Optiquest 17"                  970513       A0177766        BND 1612       461003702
          Monitor
---------------------------------------------------------------------------------------------------------
1         StarMax 3000                             970513       A0187468        CPU 0537        ST005516
---------------------------------------------------------------------------------------------------------
                                        970513 Total
---------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------
1         32 MB 168 PIN EDO DIMM                   970514       A0216127        CHP 0396             N/A
---------------------------------------------------------------------------------------------------------
1         Ether FE 10/100 PCI                      970514       A0216127        DEC 1883             N/A
---------------------------------------------------------------------------------------------------------
1         StarMax 3000                             970514       A01209171      CPU 0548         ST016198
---------------------------------------------------------------------------------------------------------
1         Power User 17" Monitor                   970514       A0285403       MON 0378       0461000803
---------------------------------------------------------------------------------------------------------
                                        970514 Total
---------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------
1         32 MB 168 PIN EDO DIMM                   970515       A0183533       CHP 0396              N/A
---------------------------------------------------------------------------------------------------------
1         Ether FE 10/100 PCI                      970515       A0183533       DEC 1883              N/A
---------------------------------------------------------------------------------------------------------
1         StarMax 3000                             970515       A0180471       CPU 0537            DS395
---------------------------------------------------------------------------------------------------------
                                        970515 Total
---------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------
1         Powerbook 3400C/180                      970550       A0356485       CPU 0578      CK7080MR7ZQ
---------------------------------------------------------------------------------------------------------
                                        970550 Total
---------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------
1         Incubator Bod MDL 146D 11                970684        6327202         97990D          1296006
---------------------------------------------------------------------------------------------------------
                                        970684 Total
---------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------
1         MaterialsDrier, Valves,                  970709          15387                             N/A
          Adapter
---------------------------------------------------------------------------------------------------------
                                        970709 Total
---------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------
1         Campaq Presario CPU                      970756       A1514223         CP4089    SA643HZY2D770
---------------------------------------------------------------------------------------------------------
1         Sony Monitor 17"                         970756       A1514223        MON0417      S017125370B
---------------------------------------------------------------------------------------------------------
                                        970756 Total
---------------------------------------------------------------------------------------------------------

<CAPTION>
-------------------------------------------------------------------------
QTY       SUPPLIER/    PURCHASE DATE    EQUIPMENT    PAID - CHECK #
           VENDOR                         COST
-------------------------------------------------------------------------
<S>       <C>          <C>              <C>          <C>
-------------------------------------------------------------------------
 1        Fisher           2/4/97        $ 1,055.33
                                         ----------
-------------------------------------------------------------------------
                                         $ 1,055.33
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           219.00         6315
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           171.00         6315
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           200.00         6315
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           549.00         6315
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97          ,375.00         6315
                                         ----------
                                           2,514.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           219.00         6404
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           171.00         6404
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97         2,139.00         6404
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           449.00         6404
                                         ----------
-------------------------------------------------------------------------
                                           2,978.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           219.00         6315
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97           171.00         6315
-------------------------------------------------------------------------
 1        MacWarehouse     3/20/97         1,375.00         6315
                                         ----------
-------------------------------------------------------------------------
                                           1,765.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse     3/25/97         4,849.00         6404
                                         ----------
-------------------------------------------------------------------------
                                           4,849.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        Fisher           4/10/97         1,854.43         6550
                                         ----------
-------------------------------------------------------------------------
                                           1,854.43
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        Thermatech       4/16/97         2,979.20         6596
                                         ----------

                                           2,979.20
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse     4/23/97         1,689.00         6564
-------------------------------------------------------------------------
 1        MacWarehouse     4/23/97           765.00         6564
                                         ----------
-------------------------------------------------------------------------
                                           2,454.00
-------------------------------------------------------------------------
</TABLE>
<PAGE>

<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------------------------
QTY        EQUIPMENT                      PURCHASE          INVOICE NO.         CATALOG       SERIAL NO.
          DESCRIPTION                       ORDER                                 NO.
---------------------------------------------------------------------------------------------------------
<S>       <C>                             <C>               <C>                 <C>         <C>

---------------------------------------------------------------------------------------------------------
 1        Dunatek Dat 8.1 Removable              970823        A1797455           DRI 1652        5401217
          Tape Drive
---------------------------------------------------------------------------------------------------------
                                          970823 Total
---------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------
 1        Campaq P/133 PC Computer               970836        A1883586           CP3448    S6703HVX6D740
---------------------------------------------------------------------------------------------------------
 1        16MB SIMM Kit                          970836        A1888247           MY6271

---------------------------------------------------------------------------------------------------------
                                          970836 Total
---------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------
 1        9.1 GB Ultra Wide Drive                970906           71821        RCH/19WDS         LA691625

---------------------------------------------------------------------------------------------------------
                                          970906 Total
---------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------
 1        Power  Center   Macintosh              971009        A3069549          CPU0465          1437754
          Clone
---------------------------------------------------------------------------------------------------------
 2        64  MB  168  Pin  DIMM                 971009        A2902922          CPU0392              N/A
          Memory
---------------------------------------------------------------------------------------------------------
 1        PCI Graphic Card                       971009        A2902922          DRI1212              N/A
---------------------------------------------------------------------------------------------------------
 1        Superscan 17" Monitor                  971009        A2916575          MON0101        T6l000557
---------------------------------------------------------------------------------------------------------
 1        3COM Ethernet Card                     971009        A2902922          DEC2209              N/A
---------------------------------------------------------------------------------------------------------
 1        Internal Zip Drive                     971009        A2902922          DRI1768              N/A

---------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------
                                          971009 Total
---------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------
 1        Power  Center   Macintosh              971010        A3069010          CPU0465          1435173
          Clone
---------------------------------------------------------------------------------------------------------
 2        64  MB  168  Pin  DIMM                 971010        A2894665          CPU0392              N/A
          Memory
---------------------------------------------------------------------------------------------------------
 1        PCI Graphic Card                       971010        A2894665          DRI1212              N/A
---------------------------------------------------------------------------------------------------------
 1        Superscan 17" Monitor                  971010        A2882363          MON0101        T6J000263

---------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------
                                          971009 Total
---------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------
                                          Grand Total

---------------------------------------------------------------------------------------------------------

<CAPTION>
-------------------------------------------------------------------------
QTY       SUPPLIER/    PURCHASE DATE    EQUIPMENT    PAID - CHECK #
           VENDOR                         COST
-------------------------------------------------------------------------
<S>       <C>          <C>            <C>            <C>
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse    4/13097        1,109.00           6564
                                      -----------
-------------------------------------------------------------------------
                                         1,109.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse    5/1/97         1,290.00           6660
-------------------------------------------------------------------------
 1        MacWarehouse    5/1/97            95.00           6660
                                      -----------
-------------------------------------------------------------------------
                                         1,385.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        RCH Products    5/21/97        2,614.00           6682
                                      -----------
-------------------------------------------------------------------------
                                         2,614.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse    6/2/97         2,470.00    To be Pd. - 6/18/97

-------------------------------------------------------------------------
 2        MacWarehouse    5/28/97          850.00    To be Pd. - 6/18/97

-------------------------------------------------------------------------
 1        MacWarehouse    5/28/97          385.00    To be Pd. - 6/18/97
-------------------------------------------------------------------------
 1        MacWarehouse    5/29/97          730.00    To be Pd. - 6/18/97
-------------------------------------------------------------------------
 1        MacWarehouse    5/28/97           85.00    To be Pd. - 6/18/97
-------------------------------------------------------------------------
 1        MacWarehouse    5/28/97          125.00    To be Pd. - 6/18/97
                                      -----------
-------------------------------------------------------------------------

-------------------------------------------------------------------------
                                         4,645.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
 1        MacWarehouse    6/2/97         2,470.00    To be Pd. - 6/18/97

-------------------------------------------------------------------------
 2        MacWarehouse    5/28/97          850.00    To be Pd. - 6/18/97

-------------------------------------------------------------------------
 1        MacWarehouse    5/28/97          385.00    To be Pd. - 6/18/97
-------------------------------------------------------------------------
 1        MacWarehouse    5/29/97          730.00    To be Pd. - 6/18/97
                                      -----------
-------------------------------------------------------------------------

-------------------------------------------------------------------------
                                         4,435.00
-------------------------------------------------------------------------

-------------------------------------------------------------------------
                                      $ 35,586.96
                                      ===========
-------------------------------------------------------------------------
</TABLE>
<PAGE>

                       ACCEPTANCE AND DELIVERY CERTIFICATE

          3-Dimensional Pharmaceuticals, Inc., as lessee ("Lessee") under the
Master Lease Agreement dated as of June 12, 1997 between Lessee and Transamerica
Business Credit Corporation, as Lessor, does hereby acknowledge the acceptance
and delivery of the equipment listed in Lease Schedule No. 1, such acceptance
and delivery having been made on the 1st day of July, 1997.

                                            3-Dimensional Pharmaceuticals, Inc.

                                            By: /s/ Scott Horvitz
                                                -------------------------------
                                                Name:    Scott Horvitz
                                                Title:   Vice President &
                                                         Chief Financial Officer
<PAGE>

                          SALE AND LEASEBACK AGREEMENT

          THIS SALE AND LEASEBACK AGREEMENT (this "Agreement"), is made as of
June 14, 1997, among 3-Dimensional Pharmaceuticals, Inc., a Delaware corporation
("Seller"), and Transamerica Business Credit Corporation, a Delaware corporation
("Buyer").

                              W I T N E S S E T H :
                              - - - - - - - - - -

          WHEREAS, Seller is the owner of the equipment more particularly
described on Exhibit II hereto (the "Equipment");

          WHEREAS, Seller desires to sell to Buyer and Buyer desires to purchase
from Seller the Equipment; and

          WHEREAS, Buyer, as a condition to such purchase, wishes to lease to
Seller and Seller wishes to lease from Buyer the Equipment under the terms and
conditions of the Master Lease Agreement dated as of June 12, 1997 and Schedule
No. 1 thereto (collectively, as amended, supplemented or otherwise modified from
time to time, the "Lease") between Buyer, as lessor, and Seller, as lessee.

          NOW, THEREFORE, in consideration of the premises herein contained and
other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties hereto hereby agree as follows:

          1.   Amount and Terms of Purchase.
               ----------------------------

                  (a) Subject to the terms and conditions of this Agreement, and
in reliance upon the representations and warranties of the Seller herein set
forth, the Buyer agrees to purchase all of the Seller's right, title and
interest in and to all of the Equipment such that the Buyer will become the
owner of all such Equipment for all purposes whatsoever. The Seller hereby
agrees that the Buyer is under no obligation to purchase any other equipment now
or in the future and shall not assert a claim that the Buyer may have any such
obligation.

                  (b) The price to be paid by the Buyer with respect to the
purchase of the Equipment (the "Purchase Price") is $34,586.96. The Purchase
Price shall be payable to the Seller on the Lease Commencement Date (as defined
in the Lease).

                  (c) The Seller shall pay any and all applicable federal,
state, county or local taxes and any and all present or future taxes or other
governmental charges arising in connection with the sale of the Equipment
hereunder, including sales, use or occupation taxes due upon the purchase by the
Buyer.

                  (d) The purchase of the Equipment shall be evidenced by a bill
of sale, substantially in the form attached hereto as Exhibit A (the "Bill of
Sale"), duly executed by the Seller.
<PAGE>

          2.   Conditions to Purchase.  The obligation of the Buyer to purchase
               ----------------------
the Equipment is subject to the following conditions:

                  (a) The Buyer shall have received this Agreement, duly
executed by the Seller.

                  (b) The Buyer shall have received the Bill of Sale, duly
executed by the Seller.

                  (c) The Buyer shall have received the Lease, duly executed by
the Seller.

                  (d) The Buyer shall have received resolutions of the Board of
Directors of the Seller approving and authorizing the execution, delivery and
performance by the Seller of this Agreement, the Lease and the notices and other
documents to be delivered by the Seller hereunder and thereunder (collectively,
the "Sale and Leaseback Documents").

                  (e) The Buyer shall have received the certificate of title or
similar evidence of ownership with respect to each item of Equipment and Uniform
Commercial Code financing statements covering the Equipment in form and
substance satisfactory to the Buyer, duly executed by the Seller.

                  (f) No material adverse change has occurred with respect to
the business, prospects, properties, results of operations, assets, liabilities
or condition (financial or otherwise) of the Seller and its affiliates, taken as
a whole, since December 31, 1996.

                  (g) The Buyer shall have received all warranties and other
documentation received or executed by Seller in connection with the original
acquisition of the Equipment by the Seller (and by its execution hereof the
Seller hereby assigns to the Buyer all such warranties and other Documentation).

                  (h) The Buyer shall have received such other approvals,
opinions or documents as the Buyer may reasonably request.

          3.   Representation  and Warranties.  To induce the Buyer to enter
               ------------------------------
into this Agreement, the Seller  represents and warrants to the Buyer that:

                  (a) The Seller is duly authorized to execute, deliver and
perform its obligations under each of the Sale and Leaseback Documents and all
corporate action required on its part for the due execution, delivery and
performance of the transactions contemplated herein and therein has been duly
and effectively taken.

                  (b) The execution, delivery and performance by the Seller of
each of the Sale and Leaseback Documents and the consummation of the
transactions contemplated herein and therein does not and will not violate any
material provision of, or result in a material default under, the Seller's
Articles or Certificates of Incorporation or By-laws or any indenture or
agreement to which the Seller is a party or to which its assets are bound or any
order, permit, law, statute, code, ordinance, rule, regulation, certificate or
any other requirement of any governmental authority or regulatory body to which
the Seller is subject, or result in the creation
<PAGE>

or imposition of any mortgage, deed of trust, pledge, security interest, lien or
encumbrance of any kind upon or with respect to the Equipment or any proceeds
thereof, other than those in favor of the Buyer as contemplated by the Sale and
Leaseback Documents.

                  (c) No authorization or approval or other action by, and no
notice to or filing with, any governmental authority or regulatory body is
required for the due execution, delivery and performance by the Seller of any of
the Sale and Leaseback Documents to which it is a party.

                  (d) Each Sale and Leaseback Document to which the Seller is a
party constitutes or will constitute, when delivered hereunder, the legal, valid
and binding obligation of the Seller enforceable against the Seller in
accordance with its respective terms, except as such enforceability may be (i)
limited by the effect of applicable bankruptcy, insolvency, reorganization or
similar laws affecting the enforcement of creditors' rights generally or (ii)
subject to the effect of general principles of equity (regardless of whether
such enforceability is considered in a proceeding at equity or at law).

                  (e) There are no actions, suits, or proceedings pending, or,
to the Seller's knowledge, threatened against or affecting the Seller which seek
to enjoin, prohibit or restrain the consummation of any of the transactions
contemplated hereby or by the other Sale and Leaseback Documents.

                  (f) Each item of Equipment is owned by the Seller free and
clear of any liens and encumbrances of any kind or description. Upon purchase of
the Equipment hereunder, the Buyer will acquire good and marketable title in and
to the Equipment.

All representations and warranties herein shall survive the execution of this
Agreement and the purchase of the Equipment.

          4.   Indemnities. The Seller agrees to indemnify, defend, and save
               -----------
harmless the Buyer and its officers, directors, employees, agents, and
attorneys, and each of them (the "Indemnified Parties"), from and against all
claims, actions, suits, and other legal proceedings, damages, costs, interest,
charges, counsel fees and other expenses and penalties (collectively, the
"Indemnified Amounts") which any of the Indemnified Parties may sustain or incur
by reason of or arising out of (i) the Seller's ownership of any Equipment prior
to the date on which such Equipment is sold to the Buyer, or the Seller's acts
or omissions prior to such date under, in connection with or relating to such
Equipment or any of the Sale and Leaseback Documents, (ii) the operation,
maintenance or use of such Equipment prior to such date, (iii) any material
inaccuracy of any of the Seller's representations or warranties contained in any
of the Sale and Leaseback Documents, (iv) the breach of any of the Seller's
covenants contained in any of the Sale and Leaseback Documents, (v) any loss or
damage to any Equipment in excess of the deductible which is not paid by
insurance or (vi) any sales, use, excise and other taxes, charges, and fees
(including, without limitation, income, franchise, business and occupation,
gross receipts, sales, use, licensing, registration, titling, personal property,
stamp and interest equalization taxes, levies, imposts, duties, charges or
withholdings of any nature), and any fines, penalties or interest thereon,
imposed or levied by any governmental body, agency or tax authority upon or in
connection with the Equipment, its acquisition, ownership, delivery, leasing,
<PAGE>

possession, use or relocation or otherwise in connection with the transactions
contemplated by each Sale and Leaseback Document, but excluding taxes on or
measured by the net income of the Buyer. Notwithstanding the foregoing, Seller
shall have no obligation to indemnify Buyer for any Indemnified Amounts which
arise out of Buyer's gross negligence or willful misconduct.

          5.   Remedies. Upon the Seller's receipt of notice from the Buyer of
               --------
Seller's violation of or default under any provision of this Agreement, the
Buyer may (subject to the provisions of the other Sale and Leaseback Documents
and after all applicable grace periods) proceed to protect and enforce its
rights either by suit in equity or by action at law or both, whether for the
specific performance of any covenant or agreement contained herein or in aid of
the exercise of any power granted in any Sale and Leaseback Document; it being
intended that the remedies contained in any Sale and Leaseback Document shall be
cumulative and shall be in addition to every other remedy given under such Sale
and Leaseback Document or now or hereafter existing at law or in equity or by
statute or otherwise.

          6.   Amendments, etc. No amendment or waiver of any provision of this
               ---------------
Agreement, nor consent to any departure therefrom, shall in any event be
effective unless the same shall be in writing and signed by the Buyer and the
Seller, and then such waiver or consent shall be effective only in the specific
instance and for the specific purpose for which given.

          7.   Notices, etc.  All notices and other communications provided
               ------------
for hereunder shall be in writing and sent:

                           if to the Seller, at its address at:

                           3-Dimensional Pharmaceuticals, Inc.
                           Eagleview Corporate Center
                           665 Stockton Drive, Suite 104
                           Exton, Pennsylvania  19341
                           Attention:  Chief Financial Officer
                           Telephone No.:  (610) 458-6043
                           Telecopy No.:  (610) 458-8258

                           if to the Buyer, at its address at:

                           Transamerica Business Credit Corporation
                           Technology Finance Division
                           76 Batterson Park Road
                           Farmington, Connecticut  06032-2571
                           Attention:  Assistant Vice President,
                                       Lease Administration
                           Telephone No.:  (860) 677-6466
                           Telecopy No.:  (860) 677-6766
<PAGE>

                           with a copy to:

                           Transamerica Business Credit Corporation
                           9399 West Higgins Road
                           Rosemont, Illinois 60018
                           Attention:  Legal Department
                           Telephone No.:  (847) 685-1106
                           Telecopy No.:  (847) 685-1143

     or to such other address as shall be designated by such party in a written
notice to the other party. All such notices shall be deemed given (i) if sent by
certified or registered mail, three days after being postmarked, (ii) if sent by
overnight delivery service, when received at the above stated addresses or when
delivery is refused and (iii) if sent by facsimile transmission, when receipt of
such transmission is acknowledged.

          8.   No Waiver; Remedies. No failure on the part of the Buyer to
               -------------------
exercise, and no delay in exercising, any right hereunder shall operate as a
waiver thereof, nor shall any single or partial exercise of any such right
preclude any other or further exercise thereof or the exercise of any other
right. The remedies herein provided are cumulative and not exclusive of any
remedies provided by law.

          9.   Benefit.  Neither  party may  transfer,  assign or delegate any
               -------
 of its rights, duties or obligations hereunder without the prior written
consent of the other party.

          10.  Binding Effect. This Agreement shall be binding upon and inure to
               --------------
the benefit of the Seller and the Buyer and their respective successors and
assigns.

          11.  GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND SHALL BE
               -------------
CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF ILLINOIS WITHOUT GIVING
EFFECT TO THE CONFLICTS OF LAW PRINCIPLES THEREOF.

          12.  Execution in Counterparts. This Agreement may be executed in any
               -------------------------
number of counterparts, each of which shall constitute an original and all of
which taken together shall constitute one and the same agreement.

          13.  Severability. If one or more of the provisions contained in this
               ------------
Agreement shall be invalid, illegal, or unenforceable in any respect, the
validity, legality, and enforceability of the remaining provisions contained
herein, and any other application thereof, shall not in any way be affected or
impaired thereby.

          14.  SUBMISSION TO JURISDICTION. ALL DISPUTES ARISING UNDER OR IN
               --------------------------
CONNECTION WITH THIS AGREEMENT BETWEEN THE PARTIES HERETO, WHETHER SOUNDING IN
CONTRACT, TORT, EQUITY OR OTHERWISE, SHALL BE RESOLVED ONLY BY STATE AND FEDERAL
COURTS LOCATED IN ILLINOIS, AND THE COURTS TO WHICH AN APPEAL THEREFROM MAY BE
TAKEN; PROVIDED, HOWEVER, THAT THE BUYER SHALL HAVE THE RIGHT, TO THE EXTENT
<PAGE>

PERMITTED BY APPLICABLE LAW, TO PROCEED AGAINST THE SELLER OR ITS PROPERTY IN
ANY LOCATION REASONABLY SELECTED BY THE BUYER IN GOOD FAITH TO ENABLE THE BUYER
TO REALIZE ON SUCH PROPERTY, OR TO ENFORCE A JUDGMENT OR OTHER COURT ORDER IN
FAVOR OF THE BUYER. THE SELLER WAIVES ANY OBJECTION THAT IT MAY HAVE TO THE
LOCATION OF THE COURT IN WHICH THE BUYER HAS COMMENCED A PROCEEDING, INCLUDING,
WITHOUT LIMITATION, ANY OBJECTION TO THE LAYING OF VENUE OR BASED ON FORUM NON
CONVENIENS.

          15.  JURY TRIAL. THE PARTIES HERETO EACH HEREBY WAIVE TO THE FULLEST
               ----------
EXTENT PERMITTED BY LAW ANY RIGHT TO A TRIAL BY JURY IN ANY ACTION OR PROCEEDING
ARISING UNDER OR IN CONNECTION WITH THIS AGREEMENT.
<PAGE>

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed
by their respective officers hereunto duly authorized, as of the first date
written above.

                                             3-DIMENSIONAL PHARMACEUTICALS,
                                             INC.

                                             By: /s/ Scott Horvitz
                                                 ---------------------------
                                                 Name: Scott Horvitz
                                                 Title:   Vice President

                                             TRANSAMERICAN BUSINESS CREDIT
                                             CORPORATION

                                             By: /s/ Gary P. Moro
                                                 ---------------------------
                                                  Name: Gary P. Moro
                                                  Title: Vice President

Exhibit II - Equipment
Exhibit A - Bill of Sale
<PAGE>

                                   EXHIBIT A

                                 BILL OF SALE

          KNOW ALL PERSONS BY THESE PRESENTS 3-Dimensional Pharmaceuticals, Inc.
(the "Seller"), for Six Hundred Fifty Seven Thousand, Three Hundred Eighty One
and 28/100 Dollars ($657,381.28) and other valuable consideration to it in hand
paid, receipt of which is hereby acknowledged, does unconditionally, absolutely
and irrevocably grant, sell, assign, transfer and convey unto TRANSAMERICA
BUSINESS CREDIT CORPORATION and its assignees or successors (collectively, the
"Buyer"), all of the Seller's right, title and interest in and to the equipment
described on Exhibit II hereto (collectively, the "Equipment").

          TO HAVE AND TO HOLD said Equipment unto the said Buyer, to and for its
use forever.

          AND, the Seller hereby warrants, covenants and agrees that it (a) has
good and marketable title to the Equipment, free and clear of any liens and
other encumbrances; and (b) will warrant and defend the sale of the Equipment
against any and all persons claiming against such title.

          IN WITNESS WHEREOF the Seller has caused this instrument to be duly
executed and delivered as of this ____ day of _________________, 1997.

                                          3-DIMENSIONAL PHARMACEUTICALS,
                                          INC.

                                          By: /s/ Scott Horvitz
                                              ------------------------
                                              Name: Scott Horvitz
                                              Title: VP & CFO
<PAGE>

                                 BILL OF SALE

          KNOW ALL PERSONS BY THESE PRESENTS 3-Dimensional Pharmaceuticals, Inc.
(the "Seller"), for Six Hundred Fifty Seven Thousand, Three Hundred Eighty One
and 28/100 Dollars ($657,381.28) and other valuable consideration to it in hand
paid, receipt of which is hereby acknowledged, does unconditionally, absolutely
and irrevocably grant, sell, assign, transfer and convey unto TRANSAMERICA
BUSINESS CREDIT CORPORATION and its assignees or successors (collectively, the
"Buyer"), all of the Seller's right, title and interest in and to the equipment
described on Exhibit II hereto (collectively, the "Equipment").

          TO HAVE AND TO HOLD said Equipment unto the said Buyer, to and for its
use forever.

          AND, the Seller hereby warrants, covenants and agrees that it (a) has
good and marketable title to the Equipment, free and clear of any liens and
other encumbrances; and (b) will warrant and defend the sale of the Equipment
against any and all persons claiming against such title.

          IN WITNESS WHEREOF the Seller has caused this instrument to be duly
executed and delivered as of this _____ day of _________________, 1997.

                                           3-DIMENSIONAL PHARMACEUTICALS,
                                           INC.

                                           By: /s/ Scott Horvitz
                                               ------------------------
                                           Name: Scott Horvitz
                                           Title: Vice President
<PAGE>

                          TECHNOLOGY FINANCE DIVISION
                            DOCUMENTATION CHECKLIST

                      3 DIMENSIONAL PHARMACEUTICALS, INC.
                           CUSTOMER NUMBER 1046-002
                                SCHEDULE NO. 2
                           AS OF SEPTEMBER 22, 1997
<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------------------------------------
                                                                           DATE
                                                                           -----
                                                          DATE            RECEIVED
                                                          ----            --------
               DOCUMENT                                   SENT               D                     COMMENTS
               --------                                   ----               -                     --------
<S>                                                        <C>            <C>         <C>
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
SCHEDULE NO. 2                                           9-24-97
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
EXHIBIT II - EQUIPMENT                                   9-24-97
---------------------------------------------------------------------------------------------------------------------------------
     RIDER I (EQUIPMENT DESCRIPTION)                                          9-24-97                 RECEIVED.
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
ACCEPTANCE AND DELIVERY CERTIFICATE                      9-24-97
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
SALE AND LEASEBACK AGREEMENT                             9-24-97
---------------------------------------------------------------------------------------------------------------------------------
         BILL OF SALE                                    9-24-97
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
PAY PROCEEDS LETTER                                      9-24-97
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
SALES TAX EXEMPTION CERTIFICATE                                                                       RECEIVED.
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
SUPPLIERS' INVOICES                                                           9-24-97                 RECEIVED.
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
INSURANCE CERTIFICATE
---------------------------------------------------------------------------------------------------------------------------------
         PROPERTY                                                                                     RECEIVED.
---------------------------------------------------------------------------------------------------------------------------------
         LIABILITY                                                                                    RECEIVED.
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
INVOICE FOR ADVANCE RANT                                 9-24-97
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
ADVANCE RENT                                                                                          DEDUCTED FROM PROCEEDS
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
UCC FINANCING STATEMENTS
---------------------------------------------------------------------------------------------------------------------------------
         JURISDICTIONS:
---------------------------------------------------------------------------------------------------------------------------------
         SOS-PA                                          9-24-97
---------------------------------------------------------------------------------------------------------------------------------
         PROTHONOTARY OF CHESTER COUNTY                  9-24-97
---------------------------------------------------------------------------------------------------------------------------------
         REAL ESTATE RECORDS OF CHESTER COUNTY                                9-24-97                 RECEIVED WITH SCH. 01
---------------------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------------
UCC LIEN SEARCH                                                                                       UPDATE RECEIVED 9-24-97
---------------------------------------------------------------------------------------------------------------------------------
JURISDICTIONS:
---------------------------------------------------------------------------------------------------------------------------------
         SOS-PA
---------------------------------------------------------------------------------------------------------------------------------
         PROTHONOTARY OF CHESTER COUNTY
---------------------------------------------------------------------------------------------------------------------------------
         REAL ESTATE RECORDS OF CHESTER COUNTY
---------------------------------------------------------------------------------------------------------------------------------
</TABLE>

<PAGE>

------------------------------------------------------------------------------

------------------------------------------------------------------------------
ANY INTERVENING LIENS?  CLEAR!
------------------------------------------------------------------------------
<PAGE>

                      SCHEDULE TO MASTER LEASE AGREEMENT

                        Dated as of September 24, 1997

                                Schedule No. 2

Lessor Name & Mailing Address                Lessee Name & Mailing Address
Transamerica Business Credit Corporation     3-Dimensional Pharmaceuticals, Inc.
Riverway II                                  Eagleview Corporate Center
West Office Tower                            665 Stockton Drive, Suite 104
9399 West Higgins Road                       Exton, Pennsylvania 1 19341
Rosemont, Illinois  60018

     Equipment Location (if different than Lessee's address above):

     This Schedule covers the following described equipment ("Equipment"):

          See Exhibit II attached hereto and made a part hereof.

     The Equipment is hereby leased pursuant to the provisions of the Master
Lease Agreement between the undersigned Lessee and Lessor dated June 12, 1997
(the "Master Lease"), the terms of which are incorporated herein by reference
thereto, plus the following additional terms, provisions, and modifications. The
Lessor reserves the right to adjust the monthly payments in accordance with the
Commitment Letter dated May 9, 1997, if the Lessor has not received this
Schedule and an Acceptance and Delivery Certificate executed by the Lessee
within five business days from the date first set forth above.

1. Term (Number of Months)                             48months
2. Equipment Cost                                      $657,381.28
3. Commencement Date                                   September 30, 1997
4. Rate Factor                                         2.5226% of Equipment Cost
5. Total Rents                                         $795,988.80
6. Advance Rents (first and last)                      $33,166.20
7. Monthly rental payments                             $16,583.10
    And the second such rental payments will be due on November 1, 1997
    and subsequent rental payments will be due on the
    same day of each month thereafter
8. Security Deposit                                    None
9. In addition to the monthly rental payments          $552.77
   provided for herein, Lessee shall pay to Lessor,
   as interim rent, payable on the commencement
   date specified above, an amount equal to 1/30th
   of the monthly rental payment (including monthly
   sales/use tax) multiplied by the number of days
   from and including the commencement date through
   the end of the same calendar month
<PAGE>

     Lessee hereby irrevocably authorizes Lessor to insert in this Schedule
the Commencement Date and the due date of the first rental payment.

     Except as expressly provided or modified hereby, all the terms and
provisions of the Master Lease Agreement shall remain in full force and effect.

     The Purchase Date shall be September 1, 2001.

     The Stipulated Loss Value of any items of Equipment shall be an amount
equal to the present value of all future Rent discounted at a rate of 8% per
annum plus the Reversionary Value.

     The Reversionary Value of any item of Equipment shall be 10% of Equipment
Cost.

TRANSAMERICA BUSINESS CREDIT            3-DIMENSIONAL PHARMACEUTICALS,
CORPORATION                             INC.
(Lessor)                                (Lessee)

By:/s/ Meg Lengson                      By:/s/ Scott Horvitz
   -------------------------------         ---------------------------------

Title: Assistant Vice President         Title: Vice President
       ---------------------------             -----------------------------
<PAGE>

                                  EXHIBIT II

To:

 X    Schedule to Master Lease Agreement
---
 X    UCC
---
 X    Collateral Access Agreement
---

                        Dated as of September 24, 1997

                                    Between

                   TRANSAMERICA BUSINESS CREDIT CORPORATION

Customer Name:           3-DIMENSIONAL PHARMACEUTICALS, INC.
Equipment Locations:     Eagleview Corporate Center
                         665 Stockton Drive, Suite 104
                         Exton, Pennsylvania  19341

                     SEE RIDER I FOR EQUIPMENT DESCRIPTION

Transamerica Business Credit Corporation    3-Dimensional Pharmaceuticals, Inc.
(Lessor)                                    (Lessee)

By:/s/ Meg Lengson                           By:/s/ Scott Horvitz
   -------------------------------              -------------------------------
                                                    Scott Horvitz

Title: Assistant Vice President              Title: Vice President
       ---------------------------                  ---------------------------
<PAGE>

                                     RIDER I
                                TO SCHEDULE NO. 1
<TABLE>
<CAPTION>
 X        Master Lease Agreement                                            3-Dimensional Pharmaceuticals, Inc.
              dated June 12, 1997                                           Equipment Sale Leaseback Schedule
 X        Schedule No. 2

  QTY         EQUIPMENT               PURCHASE ORDER       INVOICE NO.      CATALOG NO.         SERIAL NO.   SUPPLIER/
             DESCRIPTION                                                                                      VENDOR
<S>       <C>                        <C>                  <C>             <C>                  <C>        <C>
   1      CPU Board for SGI                       971207         71870     RCH/HU497                  N/A  RCH Products
          Challenge
                                     971207 Total
   1      RAID Array Disk                         971208         71871  RCH/Ultra 7-9                      RCH Products
   1      1 GB Memory for                         971208         71871     RCH/1GBR44                 N/A  RCH Products
          Challenge L
   1      Uninterruptible Power                   971208         71871     BSU1400NET        WS9715682793  RCH Products
          Supply, 1400
   1      Uninterruptible Power                   971208         71871     BSU1400NET        ES9714343935  RCH Products
          Supply, 1400
   1      CD-ROM Recorder                         971208        718871      RCH/CDWR                  N/A  RCH Products
                                     971208 Total
   1      Uninterruptible Power                   971209         71872    RCH/SU200NET       ES9725465959  RCH Products
          Supply, 2200VA
   1      Uninterruptible Power                   971209         71872    RCH/SU200NET       ES9725465960  RCH Products
          Supply, 2200VA
   1      PowerChute Plus for SUN                 971209         71872     RCH/AP9004                 N/A  RCH Products
   1      PowerChute Plus for                     971209         71872     RCH/AP9007                 N/A  RCH Products
          Windows
                                     971209 Total
   1      Uninterruptible Power                   971210         71873    RCH/SU200NET       ES9724459211  RCH Products
          Supply, 2200VA
   1      Uninterruptible Power                   971210         71873    RCH/SU200NET       ES9724459191  RCH Products
          Supply, 2200VA
   2      PowerChute Plus for                     971210         71873     RCH/AP9007                 N/A  RCH Products
          Windows
                                     871210 Total
   1      Superstack II Switch                    971211    370-009302      179416            7WKR057716   Anixler
                                     871211 Total
   1      HPLC System                             971212        168947                             70094E  Shimadzu
                                     971211 Total
   1      Gilson Liquid Handler/                  971213        146795                           259E7179  Gilson
          Autosampler System
                                     971213 Total
   1      Laboratory Wall Cabinets                971215          5840                                N/A  LF Systems
                                                                                                           Corp
                                     971215 Total
   1      Double Mirror Focusing                  971222         30584        7616                    N/A  Charles Supper

<CAPTION>

  X       UCC-1
  X       Sale and Leaseback Agreement

  QTY         EQUIPMENT              PURCHASE    EQUIPMENT       PAID - CHECK #
             DESCRIPTION               DATE        COST
<S>          <C>                     <C>      <C>                <C>
   1      CPU Board for SGI 8/28/97                                   7238
          Challenge                           $  60,000.00
                                              ------------
                                              $  60,000.00
   1      RAID Array Disk            7/15/97     27,224.00            6967
   1      1 GB Memory for            7/15/97     32,248.00            6967
          Challenge L
   1      Uninterruptible Power      7/15/97        787.00            6967
          Supply, 1400
   1      Uninterruptible Power      7/15/97        787.00            6967
          Supply, 1400
   1      CD-ROM Recorder            7/15/97      2,423.00            6967
                                              ------------
                                                 63,469.00
   1      Uninterruptible Power       7/7/97      1,181.00            6967
          Supply, 2200VA
   1      Uninterruptible Power       7/7/97      1,181.00            6967
          Supply, 2200VA
   1      PowerChute Plus for SUN     7/7/97        126.00            6967
   1      PowerChute Plus for         7/7/97                          6967
          Windows                                    55.00
                                              ------------
                                                  2,543.00
   1      Uninterruptible Power       7/7/97      1,181.00            6967
          Supply, 2200VA
   1      Uninterruptible Power       7/7/97      1,181.00            6967
          Supply, 2200VA
   2      PowerChute Plus for         7/7/97                          6967
          Windows                                   110.00
                                              ------------
                                                  2,472.00
   1      Superstack II Switch       7/18/97      2,196.65            7068
                                              ------------
                                                  2,196.65
   1      HPLC System                7/25/97     19,135.10            7238
                                              ------------
                                                  2,196.65
   1      Gilson Liquid Handler/     7/11/97     19,759.00            7140
                                              ------------
          Autosampler System
                                                 19,759.00
   1      Laboratory Wall Cabinets    9/7/97      4,811.00            7235
                                              ------------

                                                  4,811.00
   1      Double Mirror Focusing     7/15/97     19,400.00            6982
                                              ------------
</TABLE>
<PAGE>

<TABLE>
<CAPTION>

  QTY         EQUIPMENT               PURCHASE ORDER      INVOICE NO.      CATALOG NO.       SERIAL NO.       SUPPLIER/
             DESCRIPTION                                                                                       VENDOR
<S>       <C>                         <C>                  <C>             <C>               <C>           <C>
          System                                                                                           Co.

   1      Power ac 4400/200          971222 Total 971223      A4368957      CPU0611          SXB7190K79GG  Mac Warehouse
          32MB/2GB 12xCD
   1      64MB 168 Pin EDO DIMM                   971223      A4390761      CHP0397                   N/A  Mac Warehouse
   1      4.3 GB Hard Drive                       971223                    DRH1753              17200652  Mac Warehouse
   1      Power User 17" Monitor                  971223                    MONO489             561011394  Mac Warehouse
   1      Ethernet Network Card                   971223                    DEC1652                   N/A  Mac Warehouse

                                     971223 Total
   1      Octane, SGI Workstation,                971225         71878                       0800690B713E  RCH Products
          $10000
   1      Dial and Button Box for                 971225         71878                               2443  RCH Products
          Octane
   1      ONC3/NFS for Irix                       971225         71878                                N/A  RCH Products
          Operating System
   1      ProDev C++ Bundle for                   971225          7187                                N/a  RCH Products
          C++ Development
                                     971225 Total
   2      32MB 168 Pin DIMM 70 NS                 971256      A5164009      CHP0403                   N/A  Mac Warehouse
   3      Power User 15" Monitor                  971256      A5007919      MON0488                        Mac Warehouse
   3      Ethermac PCI Card                       971256      A5007919      DEC2382                   N/A  Mac Warehouse
          10Base-T
   1      32MB 168 Pin DIMM 70 NS                 971256      A5007919      CHP0403                   N/A  Mac Warehouse
   1      SuperMac C500 603E/18OLT                971256      A5040555      CPU0672       50N30A721000364  Mac Warehouse
          16MB 1.2 GB
   1      SuperMac C500 603E/18OLT                971256      A5040555      CPU0672       50N30A721000119  Mac Warehouse
          16MB 1.2GB
   1      SuperMac C500 603E/18OLT                971256      A5040555      CPU0672       50N30A723000615  Mac Warehouse

                                     971256 Total
   1      Laboratory Table,                       971277          5831                                N/A  LF Systems
          Stainless w/Blk Top                                                                              Corp
                                     971277 Total
   1      LCQ MS/DS System                        971317  S-021842-011        LCQ                LC000472  Finigan MAT
   1      ESI Probe for the LCQ                   971317  S-021842-011        201A                    N/A  Finigan MAT
          MS/DS
   1      APCI Probe for the LQC                  971317  S-021842-011        201B                    N/A  Finigan MAT
          MDS/DS
                                     971317 Total
   1      Stereo Emitter & Glasses                971322         71888                              45542  RCH Products
                                     971322 Total
   1      NB Scientific                           971393  278404073197     14-280-15            790454146  Fischer
          Reciprocating Water Bath                                                                         Scientific
   1      Water Bath Gable Cover                  971393  278404073197     14-280-28                  N/A  Fisher
                                                                                                           Scientific
                                     971393 Total
   1      Powerbook 1400CS/117                    971460      A5462593      CPU0522          SQF7020JXBJX  Mac Warehouse
          12/750MB
   1      24MB Memory Module for                  971460      A5472220      CHP0411                   N/A  Mac Warehouse
          Powerbook 140

<CAPTION>
  QTY         EQUIPMENT             PURCHASE      EQUIPMENT       PAID - CHECK #
             DESCRIPTION              DATE          COST
<S>       <C>                       <C>         <C>               <C>
                                                19,400.00
   1      Power Mac 4400/200        7/8/97       1,715.00            7062
          32MB/2GB 12xCD
   1      64MB 168 Pin EDO DIMM     7/8/97         395.00            7062
   1      4.3 GB Hard Drive         7/8/97         999.00            7062
   1      Power User 17" Monitor    7/8/97         430.00            7062
   1      Ethernet Network Card     7/8/97         122.00            7062
                                               ----------
                                                 3,661.00
   1      Octane, SGI Workstation,  7/8/97      58,446.00            6967
          $10000
   1      Dial and Button Box for   7/8/97       2,250.00            6967
          Octane
   1      ONC3/NFS for Irix         7/8/97         595.00            6967
          Operating System
   1      ProDev C++ Bundle for     7/8/97                           6967
          C++ Development                        5,500.00
                                               ----------
                                                66,791.00
   2      32MB 168 Pin DIMM 70 NS   7/29/97        330.00
   3      Power User 15" Monitor    7/24/97        795.00            7104
   3      Ethermac PCI Card         7/24/97        180.00            7104
          10Base-T
   1      32MB 168 Pin DIMM 70 NS   7/24/97        165.00            7104
   1      SuperMac C500 603E/18OLT  7/24/97        949.00            7104
          16MB 1.2 GB
   1      SuperMac C500 603E/18OLT  7/24/97        949.00            7104
          16MB 1.2GB
   1      SuperMac C500 603E/18OLT  7/24/97        949.00
                                               ----------
                                                 4,317.00            7104

   1      Laboratory Table,
          Stainless w/Blk Top       8/21/97      1,129.00            7235
                                               ----------
                                                 1,129.00
   1      LCQ MS/DS System          8/12/97    143,200.00            7239
   1      ESI  Probe for the LCQ    8/12/97     10,000.00            7239
          MS/DS
   1      APCI Probe for the LQC    8/12/97     10,000.00            7239
                                                ---------
          MDS/DS
                                               163,200.00
   1      Stereo Emitter & Glasses  7/16/97        990.00            6967
                                               ----------
                                                   990.00
   1      NB Scientific             7/29/97      2,700.00            7093
          Reciprocating Water Bath
   1      Water Bath Gable Cover    7/29/97        412.00            7093

                                                 3,112.00
   1      Powerbook 1400CS/117      8/5/97       1,645.00            7184
          12/750MB
   1      24MB Memory Module for    8/5/97         185.00            7184
          Powerbook 140
</TABLE>
<PAGE>

<TABLE>
<CAPTION>
  QTY       EQUIPMENT                   PURCHASE ORDER      INVOICE NO.    CATALOG       SERIAL NO.       SUPPLIER/    PURCHASE
           DESCRIPTION                                                       NO.                           VENDOR       DATE
  <S>   <C>                           <C>                   <C>            <C>         <C>              <C>            <C>
   1    Apple Powerbook 1400 8X                    971460      A5472220      ACC2788               N/A  Mac Warehouse    8/5/97
        CD-ROM Module
   1    Etertech Ethernet Card                     971460      A5472220      ACC2482               N/A  Mac Warehouse    8/5/97

                                      971460 Total
   1    SuperMac C500 603E/18OLT                   971461      A5501606      CPU0672   50N30A725001694  Mac Warehouse    8/6/97
        16MB/1.2GB
   1    Monitor Power User 15"                     971461      A5501606      MONO488                    Mac Warehouse    8/6/97

                                      971461 Total
   1    Printer, Epson, Stylus                     971500      A5621438      PR11948       2UUX0012670  Micro            8/8/97
        1500 Wide Carriage                                                                              Warehouse
   1    Monitor, Hitachi, 21"                      971500      A5621438      MON0362         G6H005057  Micro            8/8/97
                                                                                                        Warehouse
   1    CPU, Compaq Deskpro 6000                   971500      A5621438       CP5024     S6719BPP2Q430  Micro            8/8/97
                                                                                                        Warehouse
   1    64MB Memory Module for                     971500      A5796362       MY6945               N/A  Micro            8/8/97
        Deskpro                                                                                         Warehouse
                                      971500 Total
   1    Oil Free Diaphragm Pump,                   971504           333       696244       20062616-97  Vacuubrand,      8/28/97
        Chem(PTFE)                                                                                      Inc.
   1    Incubator, Isotemp 5.0 Cu Ft               971543  278404083197     11690650D         70800248  Fisher           8/14/97
                                                                                                        Scientific
                                      971543 Total
   1    Analytical Balance                         971557  278404083197    01-913-503B      1116283226  Fisher           8/15/97
                                                                                                        Scientific
                                      971557 Total
   1    Lab Fit-out Work - Phase 1                 979999       6/10/97                            N/A  Eagleview        5/31/97
                                                                                                        Constri.
   1    Lab Fit-out Work - Phase 2                 979999       9/16/97                            N/A  Eagleview        8/31/97
                                                                                                        Constr.
                                      979999 Total
   1    SuperMac             C500                  971725      A6776926      CPU0787   50N30A728002565  Mac Warehouse    9/10/97
        603LT/18OLT 16MB
   1    Monitor Power User 15"                     971725      A6776926      MONO488                    Mac Warehouse    9/10/97
   1    32MB 168 Pin DIMM Memory                   971725      A6791693      RDR12126              N/A  Mac Warehouse    9/10/97
        Module
   1    Zip Drive SCSI                             971725      A6791693      CHP0403               N/A  Mac Warehouse    9/10/97

                                      971725 Total
   1    Ultra Wide SCSI Disk                       971756         71942      RCH/E412         JK134135  RCH Products     9/16/97
        Drive System, 4.3GB
   1    Ultra Wide SCSI Disk                       971756         71942      RCH/E412         JK158471  RCH Products     9/16/97
        Drive System, 4.3GB
                                      971756 Total
<CAPTION>
  QTY       EQUIPMENT                                             EQUIPMENT           PAID - CHECK #
           DESCRIPTION                                             COST
  <S>   <C>                                                     <C>                   <C>
   1    Apple Powerbook 1400 8X                                      185.00                7184
        CD-ROM Module
   1    Etertech Ethernet Card                                                             7184
                                                                      85.00
                                                                -----------
                                                                   2,100.00
   1    SuperMac C500 603E/18OLT                                     930.00                7184
        16MB/1.2GB
   1    Monitor Power User 15"                                                             7184
                                                                     265.00
                                                                -----------
                                                                   1,195.00
   1    Printer, Epson, Stylus                                       469.00                7184
        1500 Wide Carriage
   1    Monitor, Hitachi, 21"                                      1,665.00                7184

   1    CPU, Compaq Deskpro 6000                                   3,149.00                7184

   1    64MB Memory Module for                                       405.00                7184
        Deskpro                                                 -----------

                                                                   5,688.00
   1    Oil Free Diaphragm Pump,                                   1,965.00                7237
        Chem(PTFE)
   1    Incubator, Isotemp 5.0 Cu F                                1,192.53                7242
                                                                -----------

                                                                   1,192.53
   1    Analytical Balance                                         2,250.00                7242
                                                                -----------

                                                                   2,250.00
   1    Lab Fit-out Work - Phase 1                                24,225.00                6660

   1    Lab Fit-out Work - Phase 2                               178,310.00                7241
                                                                -----------

                                                                 202,535.00
   1    SuperMac             C500                                    890.00                7243
        603LT/18OLT 16MB
   1    Monitor Power User 15"                                       255.00                7243
   1    32MB 168 Pin DIMM Memory                                     140.00                7243
        Module
   1    Zip Drive SCSI                                                                     7243
                                                                      95.00
                                                                -----------
                                                                   1,380.00
   1    Ultra Wide SCSI Disk                                       1,045.00                7236
        Drive System, 4.3GB
   1    Ultra Wide SCSI Disk                                                               7236
        Drive System, 4.3GB                                        1,045.00
                                                                -----------

                                                                   2,090.00
                                                                -----------

  Grand Total    N/A - NOT APPLICABLE
                 SERIAL  NUMBERS FOR  MONITORS  WILL BE
                 FORWARD - NOT CURRENTLY AVAILABLE              $657,381.28
                                                                ===========
</TABLE>
<PAGE>

                      ACCEPTANCE AND DELIVERY CERTIFICATE

          3-Dimensional Pharmaceuticals, Inc., as lessee ("Lessee") under the
Master Lease Agreement dated as of June 12, 1997 between Lessee and Transamerica
Business Credit Corporation, as Lessor, does hereby acknowledge the acceptance
and delivery of the equipment listed in Lease Schedule No. 2, such acceptance
and delivery having been made on the 30th day of September, 1997.

                                             3-Dimensional Pharmaceuticals, Inc.

                                             By: /s/ Scott Horvitz
                                                 -------------------------------
                                             Name: Scott Horvitz
                                             Title: Vice President

Form4
<PAGE>

                         SALE AND LEASEBACK AGREEMENT

          THIS SALE AND LEASEBACK AGREEMENT (this "Agreement"), is made as of
September 24, 1997, among 3-Dimensional Pharmaceuticals, Inc., a Delaware
corporation ("Seller"), and Transamerica Business Credit Corporation, a Delaware
corporation ("Buyer").

                             W I T N E S S E T H:

          WHEREAS, Seller is the owner of the equipment more particularly
described on Exhibit II hereto (the "Equipment");

          WHEREAS, Seller desires td sell to Buyer and Buyer desires to purchase
from Seller the Equipment; and

          WHEREAS, Buyer, as a condition to such purchase, wishes to lease to
Seller and Seller wishes to lease from Buyer the Equipment under the terms and
conditions of the Master Lease Agreement dated as of June 12, 1997 and Schedule
No. 2 thereto (collectively, as amended, supplemented or otherwise modified from
time to time, the "Lease") between Buyer, as lessor, and Seller, as lessee.

          NOW, THEREFORE, in consideration of the premises herein contained and
other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties hereto hereby agree as follows:

          16.  Amount and Terms of Purchase.
               ----------------------------

                    (a)  Subject to the terms and conditions of this Agreement,
and in reliance upon the representations and warranties of the Seller herein set
forth, the Buyer agrees to purchase all of the Seller's right, title and
interest in and to all of the Equipment such that the Buyer will become the
owner of all such Equipment for all purposes whatsoever. The Seller hereby
agrees that the Buyer is under no obligation to purchase any other equipment now
or in the future and shall not assert a claim that the Buyer may have any such
obligation.

                    (b)  The price to be paid by the Buyer with respect to the
purchase of the Equipment (the "Purchase Price") is $657,381.28. The Purchase
Price shall be payable to the Seller on the Lease Commencement Date (as defined
in the Lease).

                    (c)  The Seller shall pay any and all applicable federal,
state, county or local taxes and any and all present or future taxes or other
governmental charges arising in connection with the sale of the Equipment
hereunder, including sales, use or occupation taxes due upon the purchase by the
Buyer.

                    (d)  The purchase of the Equipment shall be evidenced by a
bill of sale, substantially in the form attached hereto as Exhibit A (the "Bill
of Sale"), duly executed by the Seller.
<PAGE>

          17.  Conditions to Purchase. The obligation of the Buyer to purchase
               ----------------------
the Equipment is subject to the following conditions:

                    (a)  The Buyer shall have received this Agreement, duly
executed by the Seller.

                    (b)  The Buyer shall have received the Bill of Sale, duly
executed by the Seller.

                    (c)  The Buyer shall have received the Lease, duly executed
by the Seller.

                    (d)  The Buyer shall have received resolutions of the Board
of Directors of the Seller approving and authorizing the execution, delivery and
performance by the Seller of this Agreement, the Lease and the notices and other
documents to be delivered by the Seller hereunder and thereunder (collectively,
the "Sale and Leaseback Documents").

                    (e)  The Buyer shall have received the certificate of title
or similar evidence of ownership with respect to each item of Equipment and
Uniform Commercial Code financing statements covering the Equipment in form and
substance satisfactory to the Buyer, duly executed by the Seller.

                    (f)  No material adverse change has occurred with respect to
the business, prospects, properties, results of operations, assets, liabilities
or condition (financial or otherwise) of the Seller and its affiliates, taken as
a whole, since December 31, 1996.

                    (g)  The Buyer shall have received all warranties and other
documentation received or executed by Seller in connection with the original
acquisition of the Equipment by the Seller (and by its execution hereof the
Seller hereby assigns to the Buyer all such warranties and other Documentation).

                    (h)  The Buyer shall have received such other approvals,
opinions or documents as the Buyer may reasonably request.

          18.  Representation and Warranties.  To induce the Buyer to enter
               -----------------------------
into this Agreement the Seller represents and warrants to the Buyer that:

                    (a)  The Seller is duly authorized to execute, deliver and
perform its obligations under each of the Sale and Leaseback Documents and all
corporate action required on its part for the due execution, delivery and
performance of the transactions contemplated herein and therein has been duly
and effectively taken.

                    (b)  The execution, delivery and performance by the Seller
of each of the Sale and Leaseback Documents and the consummation of the
transactions contemplated herein and therein does not and will not violate any
material provision of, or result in a material default under, the Seller's
Articles or Certificates of Incorporation or By-laws or any indenture or
agreement to which the Seller is a party or to which its assets are bound or any
order, Permit, law, statute, code, ordinance, rule, regulation, certificate or
any other requirement of any governmental authority or regulatory body to which
the Seller is subject, or result in the creation

                                      -2-
<PAGE>

or imposition of any mortgage, deed of trust, pledge, security interest, lien or
encumbrance of any kind upon or with respect to the Equipment or any proceeds
thereof, other than those in favor of the Buyer as. contemplated by the Sale and
Leaseback Documents.

                    (c)  No authorization or approval or other action by, and no
notice to or filing with, any governmental authority or regulatory body is
required for the due execution, delivery and performance by the Seller of any of
the Sale and Leaseback Documents to which it is a party.

                    (d)  Each Sale and Leaseback Document to which the Seller is
a party constitutes or will constitute, when delivered hereunder, the legal,
valid and binding obligation of the Seller enforceable against the Seller in
accordance with its respective terms, except as such enforceability may be (i)
limited by the effect of applicable bankruptcy, insolvency, reorganization or
similar laws affecting the enforcement of creditors' rights generally or (ii)
subject to the effect of general principles of equity (regardless of whether
such enforceability is considered in a proceeding at equity or at law).

                    (e)  There are no actions, suits, or proceedings pending,
or, to the Seller's knowledge, threatened against or affecting the Seller which
seek to enjoin, prohibit or restrain the consummation of any of the transactions
contemplated hereby or by the other Sale and Leaseback Documents.

                    (f)  Each item of Equipment is owned by the Seller free and
clear of any liens and encumbrances of any kind or description. Upon purchase of
the Equipment hereunder, the Buyer will acquire good and marketable title in and
to the Equipment.

         All representations and warranties herein shall survive the execution
of this Agreement and the purchase of the Equipment.

          19.  Indemnities. The Seller agrees to indemnify, defend, and save
               -----------
harmless the Buyer and its officers, directors, employees, agents, and
attorneys, and each of them (the "Indemnified Parties"), from and against all
claims, actions, suits, and other legal proceedings, damages, costs, interest,
charges, counsel fees and other expenses and penalties (collectively, the
"Indemnified Amounts") which any of the Indemnified Parties may sustain or incur
by reason of or arising out of (i) the Seller's ownership of any Equipment prior
to the date on which such Equipment is sold to the Buyer, or the Seller's acts
or omissions prior to such date under, in connection with or relating to such
Equipment or any of the Sale and Leaseback Documents, (ii) the operation,
maintenance or use of such Equipment prior to such date, (iii) any material
inaccuracy of any of the Seller's representations or warranties contained in any
of the Sale and Leaseback Documents, (iv) the breach of any of the Seller's
covenants contained in any of the Sale and Leaseback Documents, (v) any loss or
damage to any Equipment in excess of the deductible which is not paid by
insurance or (vi) any sales, use, excise and other taxes, charges, and fees
(including, without limitation, income, franchise, business and occupation,
gross receipts, sales, use, licensing, registration, titling, personal property,
stamp and interest equalization taxes, levies, imposts, duties, charges or
withholdings of any nature), and any fines, penalties or interest thereon,
imposed or levied by any governmental body, agency or tax authority upon or in
connection with the Equipment, its acquisition, ownership, delivery, leasing,

                                      -3-
<PAGE>

possession, use or relocation or otherwise in connection with the transactions
contemplated by each Sale and Leaseback Document, but excluding taxes on or
measured by the net income of the Buyer. Notwithstanding the foregoing, Seller
shall have no obligation to indemnify Buyer for any Indemnified Amounts which
arise out of Buyer's gross negligence or willful misconduct.

          20.  Remedies.  Upon the Seller's receipt of notice from the Buyer of
               --------
Seller's violation of or default under any provision of this Agreement, the
Buyer may (subject to the provisions of the other Sale and Leaseback Documents
and after all applicable grace periods) proceed to protect and enforce its
rights either by suit in equity or by action at law or both, whether for the
specific performance of any covena nt or agreement contained herein or in aid of
the exercise of any power granted in any Sale and Leaseback Document; it being
intended that the remedies contained in any Sale and Leaseback Document shall be
cumulative and shall be in addition to every other remedy given under such Sale
and Leaseback Document or now or hereafter existing at law or in equity or by
statute or otherwise.

          21.  Amendments, etc.  No amendment or waiver of any provision of this
               ---------------
Agreement, nor consent to any departure therefrom, shall in any event be
effective unless the same shall be in writing and signed by the Buyer and the
Seller, and then such waiver or consent shall be effective only in the specific
instance and for the specific purpose for which given.

          22.  Notices, etc.  All notices and other communications provided
               ------------
for hereunder shall be in writing and sent:

                    if to the Seller, at its address at:

                    3-Dimensional Pharmaceuticals, Inc.
                    Eagleview Corporate Center
                    665 Stockton Drive, Suite 104
                    Exton, Pennsylvania 19341
                    Attention: Chief Financial Officer
                    Telephone No.: (610) 458-6043
                    Telecopy No.: (610) 458-8258

                    if to the Buyer, at its address at:

                    Transamerica Business Credit Corporation
                    Technology Finance Division
                    76 Batterson Park Road
                    Farmington, Connecticut 06032-2571
                    Attention: Assistant Vice President,
                         Lease Administration
                    Telephone No.: (860) 677-6466
                    Telecopy No.: (860) 677-6766

                    with a copy to:

                    Transamerica Business Credit Corporation

                                      -4-
<PAGE>

                    9399 West Higgins Road_
                    Rosemont, Illinois 60018
                    Attention: Legal Department
                    Telephone No.: (847) 685-1106
                    Telecopy No.: (847) 685-1143

     or to such other address as shall be designated by such party in a
written notice to the other party. All such notices shall be deemed given (i) if
sent by certified or registered mail, three days after being postmarked, (ii) if
sent by overnight delivery service, when received at the above stated addresses
or when delivery is refused and (iii) if sent by facsimile transmission when
receipt of such transmission is acknowledged.

          23.  No Waiver; Remedies.  No failure on the part of the Buyer to
               -------------------
exercise, and no delay in exercising, any right hereunder shall operate as a
waiver thereof, nor shall any single or partial exercise of any such right
preclude any other or further exercise thereof or the exercise of any other
right. The remedies herein provided are cumulative and not exclusive of any
remedies provided by law.

          24.  Benefit.  Neither party may transfer, assign or delegate any of
               -------
its rights, duties or obligations hereunder without the prior written consent of
the other party.

          25.  Binding Effect.  This Agreement shall be binding upon and inure
               --------------
to the benefit of the Seller and the Buyer and their respective successors and
assigns.

          26.  GOVERNING LAW.  THIS AGREEMENT SHALL BE GOVERNED BY, AND SHALL
               -------------
BE CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF-ILLINOIS WITHOUT
GIVING EFFECT TO THE CONFLICTS OF LAW PRINCIPLES THEREOF.

          27.  Execution in Counterparts.  This Agreement may be executed in
               -------------------------
any number of counterpart, each of which shall constitute anoriginal and all of
which taken together shall constitute one and the same agreement.

          28.  Severability.  If one or more of the provisions contained in
               ------------
this Agreement shall be invalid, illegal, or unenforceable in any respect, the
validity, legality, and enforceability of the remaining provisions contained
herein, and any other application thereof, shall not in any way be affected or
impaired thereby.

          29.  SUBMISSION TO JURISDICTION.  ALL DISPUTES ARISING UNDER OR IN
               --------------------------
CONNECTION WITH THIS AGREEMENT BETWEEN THE PARTIES HERETO, WHETHER SOUNDING IN
CONTRACT, TORT, EQUITY OR OTHERWISE, SHALL BE RESOLVED ONLY BY STATE AND FEDERAL
COURTS LOCATED IN ILLINOIS, AND THE COURTS TO WHICH AN APPEAL THEREFROM MAY BE
TAKEN; PROVIDED, HOWEVER, THAT THE BUYER SHALL HAVE THE RIGHT, TO THE EXTENT
PERMITTED BY APPLICABLE LAW, TO PROCEED AGAINST THE SELLER OR ITS PROPERTY IN
ANY LOCATION REASONABLY SELECTED BY THE BUYER IN GOOD FAITH TO ENABLE THE BUYER
TO REALIZE ON SUCH PROPERTY, OR TO ENFORCE

                                      -5-
<PAGE>

A JUDGMENT OR OTHER COURT ORDER IN FAVOR OF THE BUYER. THE SELLER WAIVES ANY
OBJECTION THAT IT MAY HAVE TO THE LOCATION OF THE COURT IN WHICH THE BUYER HAS
COMMENCED A PROCEEDING, INCLUDING, WITHOUT LIMITATION, ANY OBJECTION TO THE
LAYING OF VENUE OR BASED ON FORUM NON CONVENIENS.

          30.  JURY TRIAL.  THE PARTIES HERETO EACH HEREBY WAIVE TO THE FULLEST
               ----------
EXTENT PERMITTED BY LAW ANY RIGHT TO A TRIAL BY JURY IN ANYACTION OR PROCEEDING
ARISING UNDER OR IN CONNECTION WITH TIES AGREEMENT.

          IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be executed by their respective officers hereunto duly authorized, as of the
first date written above.

                                             3-DIMENSIONAL PHARMACEUTICALS, INC.

                                             By: /s/ Scott Horvitz
                                                 -------------------------------
                                             Name. Scott Horvitz
                                             Title: Vice President

                                             TRANSAMERICA BUSINESS CREDIT
                                             CORPORATION

                                             By: M/s/ Meg Lengson
                                                 -------------------------------
                                             Name: Meg Lengson
                                             Title: Assistant Vice President

Exhibit II- Equipment
Exhibit A- Bill of Sale

                                      -6-
<PAGE>

                                   EXHIBIT A

                                 BILL OF SALE

          KNOW ALL PERSONS BY THESE PRESENTS 3-Dimensional Pharmaceuticals,
Inc. (the "Seller), for Six Hundred Fifty Seven Thousand, Three Hundred Eighty
One and 28/1 00 Dollars ($657,381.28) and other valuable consideration to it in
hand paid, receipt of which is hereby acknowledged, does unconditionally,
absolutely and irrevocably grant, sell, assign, transfer and convey unto
TRANSAMERICA BUSINESS CREDIT CORPORATION and its assignees or successors
(collectively, the "Buyer"), all of the Seller's right, title and interest in
and to the equipment described on Exhibit II hereto (collectively, the
"Equipment").

          TO HAVE AND TO HOLD said Equipment unto the said Buyer, to and for its
use forever.

          AND, the Seller hereby wan-ants, covenants and agrees that it (a) has
good and marketable title to the Equipment, free and clear of any liens and
other encumbrances; and (b) will warrant and defend the sale of the Equipment
against any and all persons claiming against such title.

          IN WITNESS WHEREOF the Seller has caused this instrument to be duly
executed and delivered as of this _______ day of ______________ 1997.

                                             3-DIMENSIONAL PHARMACEUTICALS, INC.

                                             By:  ______________________________
                                             Name:
                                             Title:

                                      -7-
<PAGE>

                                 BILL OF SALE

          KNOW ALL PERSONS BY THESE PRESENTS 3-Dimensional Pharmaceuticals, Inc.
(the "Seller"), for Six Hundred Fifty Seven Thousand, Three Hundred Eighty One
and 28/100 Dollars ($657,381.28) and other valuable consideration to it in hand
paid, receipt of which is hereby acknowledged, does unconditionally, absolutely
and irrevocably grant, sell, assign, transfer and convey unto TRANSAMERICA
BUSINESS CREDIT CORPORATION and its assignees or successors (collectively, the
"Buyer"), all of the Seller's right, title and interest in and to the equipment
described on Exhibit II hereto (collectively, the "Equipment").

          TO HAVE AND TO HOLD said Equipment unto the said Buyer, to and for its
use forever.

          AND, the Seller hereby wan-ants, covenants and agrees that it (a) has
good and marketable title to the Equipment, free and clear of any liens and
other encumbrances; and (b) will warrant and defend the sale of the Equipment
against any and all persons claiming against such title.

          IN WITNESS WHEREOF the Seller has caused this instrument to be duly
executed and delivered as of this 30th day of September, 1997.

                                             3-DIMENSIONAL PHARMACEUTICALS, INC.

                                             By: /s/ Scott Horvitz
                                                 -------------------------------
                                             Name:  Scott Horvitz
                                             Title: Vice President

                                      -8-
<PAGE>

                          TECHNOLOGY FINANCE DIVISION
                            DOCUMENTATION CHECKLIST

                      3 DIMENSIONAL PHARMACEUTICALS, INC.
                           CUSTOMER NUMBER 1046-002
                                SCHEDULE NO. 2
                           AS OF SEPTEMBER 22, 1997

<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------------------------------------
                                                                           DATE
                       DOCUMENT                           DATE SENT       RECEIVED               COMMENTS
                       --------                           ---------       --------               --------
<S>                                                       <C>             <C>                <C>
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
SCHEDULE NO. 2                                             9-24-97
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
EXHIBIT II - EQUIPMENT                                     9-24-97
---------------------------------------------------------------------------------------------------------------------
     RIDER I (EQUIPMENT DESCRIPTION)                                      9-24-97            RECEIVED.
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
ACCEPTANCE AND DELIVERY CERTIFICATE                        9-24-97
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
SALE AND LEASEBACK AGREEMENT                               9-24-97
---------------------------------------------------------------------------------------------------------------------
         BILL OF SALE                                      9-24-97
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
PAY PROCEEDS LETTER                                        9-24-97
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
SALES TAX EXEMPTION CERTIFICATE                                                              RECEIVED.
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
SUPPLIERS' INVOICES                                                       9-24-97            RECEIVED.
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
INSURANCE CERTIFICATE
---------------------------------------------------------------------------------------------------------------------
         PROPERTY                                                                            RECEIVED.
---------------------------------------------------------------------------------------------------------------------
         LIABILITY                                                                           RECEIVED.
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
INVOICE FOR ADVANCE RANT                                   9-24-97
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
ADVANCE RENT                                                                                 DEDUCTED FROM PROCEEDS
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
UCC FINANCING STATEMENTS
---------------------------------------------------------------------------------------------------------------------
         JURISDICTIONS:
---------------------------------------------------------------------------------------------------------------------
         SOS-PA                                            9-24-97
---------------------------------------------------------------------------------------------------------------------
         PROTHONOTARY OF CHESTER COUNTY                    9-24-97
---------------------------------------------------------------------------------------------------------------------
         REAL ESTATE RECORDS OF CHESTER COUNTY                            9-24-97            RECEIVED WITH SCH. 01
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
UCC LIEN SEARCH                                                                              UPDATE RECEIVED 9-24-97
---------------------------------------------------------------------------------------------------------------------
JURISDICTIONS:
---------------------------------------------------------------------------------------------------------------------
         SOS-PA
---------------------------------------------------------------------------------------------------------------------
         PROTHONOTARY OF CHESTER COUNTY
---------------------------------------------------------------------------------------------------------------------
         REAL ESTATE RECORDS OF CHESTER COUNTY
---------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      -1-
<PAGE>

<TABLE>
<S>                                              <C>             <C>            <C>
---------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------
ANY INTERVENING LIENS?  CLEAR!
---------------------------------------------------------------------------------------------------------------------
</TABLE>

                                      -2-
<PAGE>

--------------------------------------------------------------------------
--------------------------------------------------------------------------
Debtor Name (last name first if individual) and mailing address:
3-DIMENSIONAL PHARMACEUTICALS, INC.
665 STOCKTON DRIVE, SUITE 104
EXTON, PA 19341
____2716487
                                                                      1
--------------------------------------------------------------------------
Debtor Name (last name first if individual) and mailing address:

                                                                      1a
--------------------------------------------------------------------------
Debtor Name (last name first if individual) and mailing address:

                                                                      1b
--------------------------------------------------------------------------
Secured  Party(ies) name(s) (last name first if individual) and
for security interest information:

TRANSAMERICA BUSINESS CREDIT CORP.
76 BATTERSON PARK ROAD
FARMINGTON, CT 06032
36-3596947
                                                                      2
--------------------------------------------------------------------------
Assignee(s) of Secured Party name(s) (last name first if
individual) and address for security interest information

                                                                      2a
--------------------------------------------------------------------------
Special Types of Parties (check if applicable):
[_]  The terms "Debtor" and "Secured Party" mean "Lessee" and
     "Lessor," respectively
[_]  The terms "Debtor" and "Secured Party" mean "Consignee"
     and "Consignor", respectively
[_]  Debtor is a Transmitting Utility.
                                                                      3
--------------------------------------------------------------------------
                   SECURED PARTY SIGNATURE(S)
--------------------------------------------------------------------------
This statement is filed with only the Secured Party's signature
to perfect a security interest in collateral (check applicable
boxe(es)):

a.  [_]  acquired after a change of name, identity or corporate
         structure of the Debtor

b.  [_]  as to which the filing has lapsed.

c.  already subject to a security  interest in another county in
    Pennsylvania

[_] .when the collateral was moved to this county

[_]  when the  Debtor's  residence or place of business was
     moved to this county

d.  already subject to a security interest in another jurisdiction

[_] when the collateral was moved to Pennsylvania

    [_] when the Debtor's location was moved to Pennsylvania

e.  [_] which is proceeds of the collateral described in
        block 9, in which a security interest was previously
        perfected (also describe proceeds in block 9, if
        purchased with cash proceeds and not adequately
        described in the original financing statement).

1046-002
                          Secured Party Signature(s)
                 (required only if box(es) is checked above):
 TRANSAMERICA BUSINESS CREDIT CORP.
--------------------------------------------------------------------------
--------------------------------------------------------------------------
--------------------------------------------------------------------------
--------------------------------------------------------------------------
                                                                      4
--------------------------------------------------------------------------
                         FINANCING STATEMENT
                 Uniform Commercial Code Form UCC-1
               IMPORTANT - Please read instructions on
              reverse side of page 4 before completing
--------------------------------------------------------------------------
  Filing No. (stamped by       Date, Time, Filing Office
  filing officer)              (stamped by filing office)

                                                                      5
--------------------------------------------------------------------------
  This Financing Statement is presented for filing pursuant to
  the Uniform Commercial Code, and is to be filed with the (check
  applicable box)

  [_] Secretary of the Commonwealth
  [X] Prothonotary of ___________Chester__________________ County
  [_] real estate records of ______________________________ County

                                                                      6
--------------------------------------------------------------------------
  Number of Additional Sheets (if any):                               7
--------------------------------------------------------------------------
  Optional Special Identification (Max. 10 Characters)                8
--------------------------------------------------------------------------
                             COLLATERAL
--------------------------------------------------------------------------
  Identify collateral by item and/or type:

  SEE EXHIBITS I, II AND RIDER I ATTACHED HERETO AND MADE A
  PART HEREOF.

  C/S/#1046-002
  #145

  [_] (Check only if desired) Products of the collateral are
      also covered.
                                                                      9
--------------------------------------------------------------------------
  Identify related real estate, if applicable.  The collateral is,
  or includes (check appropriate box(es):
  a.  [_]  crops growing or to be grown on
  b.  [_]  good which are or are to become fixtures on
  c.  [_]  mineral or the like (including oil and gas) as extracted on
  d.  [_]  accounts resulting from the sale of minerals or the like (including
           oil and gas) at the wellhead or minehead on

  the following real estate:

  Street Address:

  Described at Book _________ of (check one) [_] Deeds [_] Mortgages,
  at Page(s) ___________ for ______________ County. Uniform Parcel Identifier
  __________________
  [_] Described on Additional Sheet
  Name of record owner (required only if no debtor has an interest of record):

                                                                      10
--------------------------------------------------------------------------
                         DEBTOR SIGNATURE(S)
--------------------------------------------------------------------------
  Debtor Signature(s):
--------------------------------------------------------------------------

         3-DIMENSIONAL PHARMACEUTICALS, INC.
  1
--------------------------------------------------------------------------

  1a
--------------------------------------------------------------------------
  1b                                                                  11
--------------------------------------------------------------------------
  RETURN RECEIPT TO:

  Data File Services, Inc.
  P.O. Box 275
  Van Nuys
  CA                         Phone    800-331-3282
  91408-2750                 Fax      818-909-4717
                                                                      12
--------------------------------------------------------------------------
<PAGE>

                              EXHIBIT I TO UCC-1
                              ------------------

Lessee:    3-Dimensional Pharmaceuticals, Inc.
Lessor:    Transamerica Business Credit Corporation

     The property described on Exhibit II and Rider I attached hereto, which
is leased pursuant to Master Lease Agreement dated Jung 12, 1997 between
above-named Lessee and Lessor, and Schedule No. 2 thereto collectively, the
"Lease'), all replacements, substitutions, additions, attachments, accessions,
parts, fittings and accessories thereto and therefor, whether owned or hereafter
acquired and all proceeds (including insurance proceeds and any sublease and the
rentals and profits thereon) of and from said property. The Secured Party is a
Lessor and the Debtor is a Lessee in respect to the leased property' `and the
Lease is not intended as a security agreement to create a security interest 'm
Lessor. This statement is not to be evidence that the Lease is a security
agreement, but if it is determined to be so for other reasons, this financing
statement is filed to perfect-the Secured Party's security interest in the
property.

LESSOR:                                LESSEE:
TRANSAMEFICA BUSINESS                  3-DIMENSIONAL
CREDIT CORPORATION                     PHARMACEUTICALS, INC.

By:____________________________        By: /s/ Scott Horvitz
                                          --------------------------------
Title:_________________________        Title: VP
                                             -----------------------------
Date:__________________________        Date: Sept. 25, 1997
                                             -----------------------------
<PAGE>

                                  EXHIBIT II

To:
     X    Schedule to Master Lease Agreement
    ---
     X    UCC
    ---
     X    Collateral Access Agreement
    ---

                        Dated as of September 24, 1997

                                    Between

                   TRANSAMERICA BUSINESS CREDIT CORPORATION

Customer Name:             3-DIMENSIONAL PHARMACEUTICALS, INC.
Equipment Locations:       Eagleview Corporate Center
                           665 Stockton Drive, Suite 104
                           Exton, Pennsylvania  19341

                     SEE RIDER I FOR EQUIPMENT DESCRIPTION

Transamerica Business Credit Corporation    3-Dimensional Pharmaceuticals, Inc.
(Lessor)                                    (Lessee)

By:_______________________________          By: /s/Scott Horvitz
                                               --------------------------------
                                                   Scott Horvitz

Title:____________________________          Title:  Vice President

<PAGE>

                                    RIDER I
                               TO SCHEDULE NO. 1

<TABLE>
<CAPTION>
X        Master Lease Agreement dated June 12, 1997                        3-Dimensional Pharmaceuticals, Inc.
X        Schedule No. 2                                                     Equipment Sale Leaseback Schedule

  QTY       EQUIPMENT DESCRIPTION      PURCHASE ORDER      INVOICE NO.    CATALOG NO.       SERIAL NO.
<S>       <C>                        <C>                   <C>            <C>               <C>
   1      CPU Board for SGI                       971207         71870     RCH/HU497                  N/A
          Challenge
                                     971207 Total
   1      RAID Array Disk                         971208         71871   RCH/Ultra 7-9
   1      1 GB Memory for                         971208         71871     RCH/1GBR44                 N/A
          Challenge L
   1      Uninterruptible Power                   971208         71871     BSU1400NET        WS9715682793
          Supply, 1400
   1      Uninterruptible Power                   971208         71871     BSU1400NET        ES9714343935
          Supply, 1400
   1      CD-ROM Recorder                         971208        718871      RCH/CDWR                  N/A
                                     971208 Total
   1      Uninterruptible Power                   971209         71872    RCH/SU200NET       ES9725465959
          Supply, 2200VA
   1      Uninterruptible Power                   971209         71872    RCH/SU200NET       ES9725465960
          Supply, 2200VA
   1      PowerChute Plus for SUN                 971209         71872     RCH/AP9004                 N/A
   1      PowerChute Plus for                     971209         71872     RCH/AP9007                 N/A
          Windows
                                     971209 Total
   1      Uninterruptible Power                   971210         71873    RCH/SU200NET       ES9724459211
          Supply, 2200VA
   1      Uninterruptible Power                   971210         71873    RCH/SU200NET       ES9724459191
          Supply, 2200VA
   2      PowerChute Plus for                     971210         71873     RCH/AP9007                 N/A
          Windows
                                     871210 Total
   1      Superstack II Switch                    971211     370-009302      179416             7WKR057716
                                     871211 Total
   1      HPLC System                             971212        168947                             70094E
                                     971211 Total
   1      Gilson Liquid Handler/                  971213        146795                            259E7179
          Autosampler System
                                     971213 Total
   1      Laboratory Wall Cabinets                971215          5840                                N/A

                                     971215 Total
   1      Double Mirror Focusing                  971222         30584        7616                    N/A
          System
                                     971222 Total
   1      Power Mac 4400/200                     971223      A4368957      CPU0611           SXB7190K79GG
          32MB/2GB 12xCD
   1      64MB 168 Pin EDO DIMM                   971223      A4390761      CHP0397                   N/A

<CAPTION>
                                                                          X        UCC-1
                                                                          X        Sale and Leaseback Agreement

  QTY       EQUIPMENT DESCRIPTION                   SUPPLIER/       PURCHASE      EQUIPMENT       PAID - CHECK #
                                                      VENDOR          DATE          COST
<S>       <C>                                     <C>               <C>         <C>               <C>
   1      CPU Board for SGI                       RCH Products        8/28/97                          7238
          Challenge                                                             $  60,000.00
                                                                                ------------
                                                                                $  60,000.00
   1      RAID Array Disk                         RCH Products        7/15/97      27,224.00           6967
   1      1 GB Memory for                         RCH Products        7/15/97      32,248.00           6967
          Challenge L
   1      Uninterruptible Power                   RCH Products        7/15/97         787.00           6967
          Supply, 1400
   1      Uninterruptible Power                   RCH Products        7/15/97         787.00           6967
          Supply, 1400
   1      CD-ROM Recorder                         RCH Products        7/15/97       2,423.00           6967
                                                                                 -----------
                                                                                   63,469.00
   1      Uninterruptible Power                   RCH Products         7/7/97       1,181.00           6967
          Supply, 2200VA
   1      Uninterruptible Power                   RCH Products         7/7/97       1,181.00           6967
          Supply, 2200VA
   1      PowerChute Plus for SUN                 RCH Products         7/7/97         126.00           6967
   1      PowerChute Plus for                     RCH Products         7/7/97          55.00
          Windows                                                                -----------
                                                                                    2,543.00
   1      Uninterruptible Power                   RCH Products         7/7/97       1,181.00           6967
          Supply, 2200VA
   1      Uninterruptible Power                   RCH Products         7/7/97       1,181.00           6967
          Supply, 2200VA
   2      PowerChute Plus for                     RCH Products         7/7/97         110.00           6967
          Windows                                                                -----------

                                                                                    2,472.00
   1      Superstack II Switch                    Anixler             7/18/97       2,196.65           7068
                                                                                 -----------
                                                                                    2,196.65
   1      HPLC System                             Shimadzu            7/25/97      19,135.10           7238
                                                                                 -----------
                                                                                    2,196.65
   1      Gilson Liquid Handler/                  Gilson              7/11/97      19,759.00           7140
          Autosampler System                                                     -----------

                                                                                   19,759.00
   1      Laboratory Wall Cabinets                LF Systems           9/7/97       4,811.00           7235
                                                  Corp                           -----------

                                                                                    4,811.00
   1      Double Mirror Focusing                  Charles Supper      7/15/97      19,400.00           6982
          System                                  Co.                            -----------

                                                                                   19,400.00
   1      Power Mac 4400/200                      Mac Warehouse        7/8/97       1,715.00           7062
          32MB/2GB 12xCD
   1      64MB 168 Pin EDO DIMM                   Mac Warehouse        7/8/97         395.00           7062
</TABLE>
<PAGE>

<TABLE>
<CAPTION>
QTY   EQUIPMENT DESCRIPTION     PURCHASE ORDER   INVOICE NO.       CATALOG        SERIAL NO.         SUPPLIER/    PURCHASE
                                                                     NO.                              VENDOR        DATE
<S>  <C>                        <C>              <C>               <C>        <C>                 <C>             <C>
 1   4.3 GB Hard Drive                    971223                   DRH1753           17200652     Mac Warehouse    7/8/97
 1   Power User 17" Monitor               971223                   MONO489          561011394     Mac Warehouse    7/8/97
 1   Ethernet Network Card                971223                   DEC1652                N/A     Mac Warehouse    7/8/97

                                  971223 Total
 1  Octane, SGI Workstation,
    $10000                                971225         71878                   0800690B713E     RCH Products     7/8/97
 1  Dial and Button Box for
    Octane                                971225         71878                           2443     RCH Products     7/8/97
 1  ONC3/NFS for Irix                     971225         71878                            N/A     RCH Products     7/8/97
    Operating system
 1  ProDev C++ Bundle for C++             971225          7187                            N/a     RCH Products     7/8/97
    Development

                                  971225 Total
 2  32MB 168 Pin DIMM 70 NS               971256      A5164009     CHP0403                N/A     Mac Warehouse   7/29/97
 3  Power User 15" Monitor                971256      A5007919     MON0488                        Mac Warehouse   7/24/97
 3  Ethermac PCI Card 10Base-T            971256      A5007919     DEC2382                N/A     Mac Warehouse   7/24/97
 1  32MB 168 Pin DIMM 70 NS               971256      A5007919     CHP0403                N/A     Mac Warehouse   7/24/97
 1  SuperMac C500 603E/18OLT              971256      A5040555     CPU0672    50N30A721000364     Mac Warehouse   7/24/97
    16MB  1.2 GB
 1  SuperMac C500 603E/18OLT 16MB         971256      A5040555     CPU0672    50N30A721000119     Mac Warehouse   7/24/97
    1.2GB
 1  SuperMac C500 603E/18OLT              971256      A5040555     CPU0672    50N30A723000615     Mac Warehouse   7/24/97

                                  971256 Total
 1  Laboratory Table, Stainless           971277          5831                            N/A     LF Systems      8/21/97
    w/Blk Top                                                                                     Corp

                                  971277 Total
 1  LCQ MS/DS System                      971317  S-021842-011         LCQ           LC000472     Finigan MAT     8/12/97
 1  ESI Probe for the LCQ MS/DS           971317  S-021842-011        201A                N/A     Finigan MAT     8/12/97
 1  APCI Probe for the LQC MDS/DS         971317  S-021842-011        201B                N/A     Finigan MAT     8/12/97

                                  971317 Total
 1  Stereo Emitter & Glasses              971322         71888                          45542     RCH Products    7/16/97

                                  971322 Total
 1  NB Scientific Reciprocating           971393  278404073197   14-280-15          790454146     Fisher          7/29/97
    Water Bath                                                                                    Scientific
 1  Water Bath Gable Cover                971393  278404073197   14-280-28                N/A     Fisher          7/29/97
                                                                                                  Scientific

                                  971393 Total
 1  Powerbook 1400CS/117 12/750MB         971460      A5462593     CPU0522       SQF7020JXBJX     Mac Warehouse    8/5/97
 1  24MB Memory Module for                971460      A5472220     CHP0411                N/A     Mac Warehouse    8/5/97
    Powerbook 140
 1  Apple Powerbook 1400 8X CD-ROM        971460      A5472220     ACC2788                N/A     Mac Warehouse    8/5/97
    Module
 1  Etertech Ethernet Card                971460      A5472220     ACC2482                N/A     Mac Warehouse    8/5/97

                                  971460 Total
 1  SuperMac C500 603E/18OLT              971461      A5501606     CPU0672    50N30A725001694     Mac Warehouse    8/6/97
    16MB/1.2GB
 1  Monitor Power User 15"                971461      A5501606     MONO488                        Mac Warehouse    8/6/97
                                  971461 Total
 1  Printer, Epson, Stylus 1500           971500      A5621438     PR11948        2UUX0012670     Micro Warehouse  8/8/97
    Wide Carriage

<CAPTION>
QTY   EQUIPMENT DESCRIPTION     EQUIPMENT       PAID - CHECK #
                                   COST
<S>  <C>                        <C>             <C>
 1   4.3 GB Hard Drive                999.00        7062
 1   Power User 17" Monitor           430.00        7062
 1   Ethernet Network Card            122.00        7062
                                  ----------
                                    3,661.00
 1  Octane, SGI Workstation,       58,446.00        6967
    $10000
 1  Dial and Button Box for         2,250.00        6967
    Octane
 1  ONC3/NFS for Irix                 595.00        6967
    Operating system
 1  ProDev C++ Bundle for C++       5,500.00        6967
    Development
                                  ----------
                                   66,791.00
 2  32MB 168 Pin DIMM 70 NS           330.00
 3  Power User 15" Monitor            795.00        7104
 3  Ethermac PCI Card 10Base-T        180.00        7104
 1  32MB 168 Pin DIMM 70 NS           165.00        7104
 1  SuperMac C500 603E/18OLT          949.00        7104
    16MB 1.2 GB
 1  SuperMac C500 603E/18OLT 16M      949.00        7104
    1.2GB
 1  SuperMac C500 603E/18OLT          949.00        7104
                                  ----------
                                    4,317.00
 1  Laboratory Table, Stainless     1,129.00        7235
    w/Blk Top                     ----------
                                    1,129.00
 1  LCQ MS/DS System              143,200.00        7239
 1  ESI Probe for the LCQ MS/DS    10,000.00        7239
 1  APCI Probe for the LQC MDS/D   10,000.00        7239
                                  ----------
                                  163,200.00
 1  Stereo Emitter & Glasses          990.00        6967
                                  ----------
                                      990.00
 1  NB Scientific Reciprocating     2,700.00        7093
    Water Bath
 1  Water Bath Gable Cover            412.00        7093
                                  ----------
                                    3,112.00
 1  Powerbook 1400CS/117 12/750M    1,645.00        7184
 1  24MB Memory Module for            185.00        7184
    Powerbook 140
 1  Apple Powerbook 1400 8X CD-R      185.00        7184
    Module
 1  Etertech Ethernet Card             85.00        7184
                                  ----------
                                    2,100.00
 1  SuperMac C500 603E/18OLT          930.00        7184
    16MB/1.2GB
 1  Monitor Power User 15"            265.00        7184
                                  ----------
                                    1,195.00
 1  Printer, Epson, Stylus 1500       469.00        7184
    Wide Carriage
</TABLE>
<PAGE>

<TABLE>
<CAPTION>
  QTY      EQUIPMENT                 PURCHASE ORDER      INVOICE NO.      CATALOG        SERIAL NO.       SUPPLIER/    PURCHASE
           DESCRIPTION                                                      NO.                             VENDOR       DATE
  <C>   <C>                          <C>                <C>             <C>            <C>              <C>            <C>
   1    Monitor, Hitachi, 21"                   971500      A5621438      MON0362            G6H005057  Micro            8/8/97
                                                                                                        Warehouse
   1    CPU, Compaq Deskpro 6000                971500      A5621438       CP5024        S6719BPP2Q430  Micro            8/8/97
                                                                                                        Warehouse
   1    64MB Memory Module for                  971500      A5796362       MY6945                  N/A  Micro            8/8/97
        Deskpro                                                                                         Warehouse
                                      971500 Total
   1    Oil Free Diaphragm  Pump,               971504           333       696244          20062616-97  Vacuubrand,      8/28/97
        Chem(PTFE)                                                                                      Inc.
   1    Incubator, Isotemp 5.0 Cu Ft            971543  278404083197     11690650D            70800248  Fisher           8/14/97
                                                                                                        Scientific
                                      971543 Total
   1    Analytical Balance                      971557  278404083197    01-913-503B         1116283226  Fisher           8/15/97
                                                                                                        Scientific
                                      971557 Total
   1    Lab Fit-out Work - Phase 1              979999       6/10/97                               N/A  Eagleview        5/31/97
                                                                                                        Constri.
   1    Lab Fit-out Work - Phase 2              979999       9/16/97                               N/A  Eagleview        8/31/97
                                                                                                        Constr.
                                      979999 Total
   1    SuperMac             C500               971725      A6776926      CPU0787      50N30A728002565  Mac Warehouse    9/10/97
        603LT/18OLT 16MB
   1    Monitor Power User 15"                  971725      A6776926      MONO488                       Mac Warehouse    9/10/97
   1    32MB 168 Pin DIMM                       971725      A6791693      RDR12126                 N/A  Mac Warehouse    9/10/97
        Memory Module
   1    Zip Drive SCSI                          971725      A6791693      CHP0403                  N/A  Mac Warehouse    9/10/97

                                      971725 Total
   1    Ultra Wide SCSI Disk                    971756         71942      RCH/E412            JK134135  RCH Products     9/16/97
        Drive System, 4.3GB
   1    Ultra Wide SCSI Disk                    971756         71942      RCH/E412            JK158471  RCH Products     9/16/97
        Drive System, 4.3GB
                                      971756 Total
<CAPTION>
  QTY      EQUIPMENT                                           EQUIPMENT          PAID - CHECK #
           DESCRIPTION                                           COST
  <S>   <C>                                                  <C>                  <C>
   1    Monitor, Hitachi, 21"                                   1,665.00               7184

   1    CPU, Compaq Deskpro 6000                                3,149.00               7184

   1    64MB Memory Module for Deskpro                            405.00               7184
                                                             -----------

                                                                5,688.00
   1    Oil Free Diaphragm  Pump,                               1,965.00               7237
        Chem(PTFE)
   1    Incubator, Isotemp 5.0 Cu Ft                            1,192.53               7242
                                                             -----------

                                                               1,192..53
   1    Analytical Balance                                      2,250.00               7242
                                                             -----------

                                                                2,250.00
   1    Lab Fit-out Work - Phase 1                             24,225.00               6660

   1    Lab Fit-out Work - Phase 2                            178,310.00               7241
                                                             -----------

                                                              202,535.00
   1    SuperMac             C500                                 890.00               7243
        603LT/18OLT 16MB
   1    Monitor Power User 15"                                    255.00               7243
   1    32MB 168 Pin DIMM Memory Module                           140.00               7243
   1    Zip Drive SCSI                                             95.00               7243
                                                             -----------
                                                                1,380.00
   1    Ultra Wide SCSI Disk                                    1,045.00               7236
        Drive System, 4.3GB
   1    Ultra Wide SCSI Disk                                                           7236
        Drive System, 4.3GB                                     1,045.00
                                                             -----------

                                                                2,090.00
                                                             -----------
Grand Total         N/A - NOT APPLICABLE
                    SERIAL NUMBERS FOR MONITORS WILL BE
                    FORWARD - NOT CURRENTLY AVAILABLE        $657,381.28
                                                             ===========
</TABLE>
<PAGE>

-------------------------------------------------------------------------------
-------------------------------------------------------------------------------
Debtor  Name  (last  name  first  if  individual)  and  mailing address:
3-DIMENSIONAL PHARMACEUTICALS, INC.
665 STOCKTON DRIVE, SUITE 104
EXTON, PA 19341
____2716487
                                                                             1
-------------------------------------------------------------------------------
Debtor Name (last name first if individual) and mailing address:

                                                                             1a
-------------------------------------------------------------------------------
Debtor Name (last name first if individual) and mailing address:

                                                                             1b
-------------------------------------------------------------------------------
Secured  Party(ies) name(s) (last name first if individual) and
for security interest information:
TRANSAMERICA BUSINESS CREDIT CORP.
76 BATTERSON PARK ROAD
FARMINGTON, CT 06032
36-3596947
                                                                             2
-------------------------------------------------------------------------------
Assignee(s) of Secured Party name(s) (last name first if individual) and address
for security interest information

                                                                             2a
-------------------------------------------------------------------------------
Special Types of Parties (check if applicable):
[_] The terms "Debtor" and "Secured Party" mean "Lessee" and "Lessor,"
    respectively
[_] The terms "Debtor" and "Secured Party" mean "Consignee" and "Consignor",
    respectively
[_] Debtor is a Transmitting Utility.
                                                                             3
-------------------------------------------------------------------------------
                          SECURED PARTY SIGNATURE(S)
-------------------------------------------------------------------------------
This statement is filed with only the Secured Party's signature to perfect a
security interest in collateral (check applicable boxe(es)):
a. [_] acquired after a change of name, identity or corporate structure of the
       Debtor
b. [_] as to which the filing has lapsed.
c. already subject to a security  interest in another county in Pennsylvania
[_]    .when the collateral was moved to this county
[_]    when the  Debtor's  residence or place of business was moved to this
       county
d. already subject to a security interest in another jurisdiction
[_]    when the collateral was moved to Pennsylvania
       [_] when the Debtor's location was moved to Pennsylvania
e. [_] which is proceeds of the collateral described in block 9, in which a
       security interest was previously perfected (also describe proceeds in
       block 9, if purchased with cash proceeds and not adequately described in
       the original financing statement).
1046-002
                          Secured Party Signature(s)
                 (required only if box(es) is checked above):
 TRANSAMERICA BUSINESS CREDIT CORP.
-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------
                                                                             4
-------------------------------------------------------------------------------

-------------------------------------------------------------------------------
                              FINANCING STATEMENT
                      Uniform Commercial Code Form UCC-1
                    IMPORTANT - Please read instructions on
                   reverse side of page 4 before completing
-------------------------------------------------------------------------------
  Filing No. (stamped by filing officer)    Date, Time, Filing Office (stamped
                                            by filing office)

                                                                             5
-------------------------------------------------------------------------------
  This Financing Statement is presented for filing pursuant to the Uniform
  Commercial Code, and is to be filed with the (check applicable box)
  [_] Secretary of the Commonwealth
  [X] Prothonotary of      Chester      County
                      -----------------
  [_] real estate records of __________ County
                                                                             6
-------------------------------------------------------------------------------
  Number of Additional Sheets (if any):                                      7
-------------------------------------------------------------------------------
  Optional Special Identification (Max. 10 Characters)                       8
-------------------------------------------------------------------------------
                                  COLLATERAL
-------------------------------------------------------------------------------
  Identify collateral by item and/or type:

  SEE EXHIBITS I, II AND RIDER I ATTACHED HERETO AND MADE A PART HEREOF.

  C/S/#1046-002
  #145

  [_] (Check only if desired) Products of the collateral are also covered.
                                                                             9
-------------------------------------------------------------------------------
  Identify related real estate,  if applicable.  The collateral is,
  or includes (check appropriate box(es):
  a.  [_]  crops growing or to be grown on
  b.  [_]  good which are or  are to become fixtures on
  c.  [_]  mineral or the like (including oil and gas) as extracted on
  d.  [_]  accounts resulting from the sale of minerals or the like (including
           oil and gas) at the wellhead or minehead on

  the following real estate:

  Street Address:

  Described at Book _________ of (check one) |_| Deeds |_| Mortgages, at Page(s)
  ___________ for ______________ County. Uniform Parcel Identifier ___________
  [_] Described on Additional Sheet
  Name of record owner (required only if no debtor has an interest of record):
                                                                             10
-------------------------------------------------------------------------------
                              DEBTOR SIGNATURE(S)
-------------------------------------------------------------------------------
  Debtor Signature(s):
-------------------------------------------------------------------------------

     3-DIMENSIONAL PHARMACEUTICALS, INC.
  1
-------------------------------------------------------------------------------

  1a
-------------------------------------------------------------------------------
  1b                                                                         11
-------------------------------------------------------------------------------
  RETURN RECEIPT TO:

  Data File Services, Inc.
  P.O. Box 275
  Van Nuys
  CA                         Phone    800-331-3282
  91408-2750                 Fax      818-909-4717
                                                                             12
-------------------------------------------------------------------------------

                                       65
<PAGE>

                              EXHIBIT I TO UCC-1
                              ------------------

Lessee:     3-Dimensional Pharmaceuticals, Inc.
Lessor:     Transamerica Business Credit Corporation

     The property described on Exhibit II and Rider I attached hereto, which is
leased pursuant to Master Lease Agreement dated Jung 12, 1997 between above-
named Lessee and Lessor, and Schedule No. 2 thereto collectively, the "Lease"),
all replacements, substitutions, additions, attachments, accessions, parts,
fittings and accessories thereto and therefor, whether owned or hereafter
acquired and all proceeds (including insurance proceeds and any sublease and the
rentals and profits thereon) of and from said property. The Secured Party is a
Lessor and the Debtor is a Lessee in respect to the leased property' ` and the
Lease is not intended as a security agreement to create a security interest `m
Lessor. This statement is not to be evidence that the Lease is a security
agreement, but if it is determined to be so for other reasons, this financing
statement is filed to perfect-the Secured Party's security interest in the
property.

LESSOR:                                    LESSEE:
TRANSAMEFICA BUSINESS                      3-DIMENSIONAL
CREDIT CORPORATION                         PHARMACEUTICALS, INC.

By:____________________________            By: /s/ Scott Horvitz
                                               -------------------------------
Title:_________________________            Title: VP
                                                  ----------------------------
Date:__________________________            Date: Sept. 25, 1997
                                                 -----------------------------

                                       66
<PAGE>

                                   EXHIBIT II
                                   ----------

To:
     X     Schedule to Master Lease Agreement
    ---
     X     UCC
    ---
     X     Collateral Access Agreement
    ---

                        Dated as of September 24, 1997

                                    Between

                   TRANSAMERICA BUSINESS CREDIT CORPORATION

Customer Name:           3-DIMENSIONAL PHARMACEUTICALS, INC.
Equipment Locations:     Eagleview Corporate Center
                         665 Stockton Drive, Suite 104
                         Exton, Pennsylvania 19341

                     SEE RIDER I FOR EQUIPMENT DESCRIPTION

Transamerica Business Credit Corporation    3-Dimensional Pharmaceuticals, Inc.
(Lessor)                                    (Lessee)

By:_____________________________________    By: /s/ Scott Horvitz
                                                --------------------------------
                                                    Scott Horvitz

Title:__________________________________    Title: Vice President
                                                   -----------------------------

                                       67
<PAGE>

                                    RIDER I
                               TO SCHEDULE NO. 1

<TABLE>
<CAPTION>
X        Master Lease Agreement                                            3-Dimensional Pharmaceuticals, Inc.
                 dated June 12, 1997                                        Equipment Sale Leaseback Schedule
X        Schedule No. 2

  QTY       EQUIPMENT DESCRIPTION      PURCHASE ORDER      INVOICE NO.    CATALOG NO.       SERIAL NO.       SUPPLIER/
                                                                                                               VENDOR
<S>       <C>                          <C>                 <C>            <C>               <C>              <C>
   1      CPU    Board    for   SGI               971207         71870     RCH/HU497                  N/A    RCH Products
          Challenge
                                       971207 Total
   1      RAID Array Disk                         971208         71871     RCH/Ultra 7-9                     RCH Products
   1      1 GB Memory for                         971208         71871     RCH/1GBR44                 N/A    RCH Products
          Challenge L
   1      Uninterruptible     Power               971208         71871     BSU1400NET        WS9715682793    RCH Products
          Supply, 1400
   1      Uninterruptible     Power               971208         71871     BSU1400NET        ES9714343935    RCH Products
          Supply, 1400
   1      CD-ROM Recorder                         971208        718871     RCH/CDWR                  N/A     RCH Products

                                       971208 Total
   1      Uninterruptible     Power               971209         71872    RCH/SU200NET       ES9725465959    RCH Products
          Supply, 2200VA
   1      Uninterruptible     Power               971209         71872    RCH/SU200NET       ES9725465960    RCH Products
          Supply, 2200VA
   1      PowerChute Plus for SUN                 971209         71872     RCH/AP9004                 N/A    RCH Products
   1      PowerChute    Plus    for               971209         71872     RCH/AP9007                 N/A    RCH Products
          Windows
                                       971209 Total
   1      Uninterruptible     Power               971210         71873    RCH/SU200NET       ES9724459211    RCH Products
          Supply, 2200VA
   1      Uninterruptible     Power               971210         71873    RCH/SU200NET       ES9724459191    RCH Products
          Supply, 2200VA
   2      PowerChute    Plus    for               971210         71873     RCH/AP9007                 N/A    RCH Products
          Windows
                                       871210 Total
   1      Superstack II Switch                    971211     370-009302      179416             7WKR057716   Anixler
                                       871211 Total
   1      HPLC System                             971212        168947                             70094E    Shimadzu
                                       971211 Total
   1      Gilson  Liquid   Handler/               971213        146795                            259E7179   Gilson
          Autosampler System
                                       971213 Total
   1      Laboratory Wall Cabinets                971215          5840                                N/A    LF     Systems
                                                                                                             Corp
                                       971215 Total
   1      Double  Mirror   Focusing               971222         30584        7616                    N/A    Charles
          System                                                                                             Supper Co.
                                       971222 Total
   1      Power    Mac     4400/200               971223      A4368957      CPU0611           SXB7190K79GG   Mac Warehouse
          32MB/2GB 12xCD

<CAPTION>
                                                      X        UCC-1
                                                      X        Sale and Leaseback Agreement

  QTY       EQUIPMENT DESCRIPTION                 PURCHASE      EQUIPMENT       PAID - CHECK #
                                                    DATE          COST
<S>       <C>                                     <C>         <C>               <C>
   1      CPU    Board    for   SGI
          Challenge                                 8/28/97                           7238
                                                              $  60,000.00
                                                              ------------
   1      RAID Array Disk                                     $  60,000.00
   1      1    GB    Memory     for                 7/15/97      27,224.00            6967
          Challenge L                               7/15/97      32,248.00            6967
   1      Uninterruptible     Power
          Supply, 1400                              7/15/97         787.00            6967
   1      Uninterruptible     Power
          Supply, 1400                              7/15/97         787.00            6967
   1      CD-ROM Recorder
                                                    7/15/97       2,423.00            6967
                                                              ------------
   1      Uninterruptible     Power                              63,469.00
          Supply, 2200VA                            7/7/97        1,181.00            6967
   1      Uninterruptible     Power
          Supply, 2200VA                            7/7/97        1,181.00            6967
   1      PowerChute Plus for SUN
   1      PowerChute    Plus    for                 7/7/97          126.00            6967
          Windows                                   7/7/97           55.00            6967
                                                              ------------

   1      Uninterruptible     Power                               2,543.00
          Supply, 2200VA                            7/7/97        1,181.00            6967
   1      Uninterruptible     Power
          Supply, 2200VA                            7/7/97        1,181.00            6967
   2      PowerChute    Plus    for
          Windows                                   7/7/97          110.00            6967
                                                              ------------

   1      Superstack II Switch                                    2,472.00
                                                    7/18/97       2,196.65            7068
                                                              ------------
   1      HPLC System                                             2,196.65
                                                    7/25/97      19,135.10            7238
                                                              ------------
   1      Gilson  Liquid   Handler/                               2,196.65
          Autosampler System                        7/11/97      19,759.00            7140
                                                              ------------

   1      Laboratory Wall Cabinets                               19,759.00
                                                     9/7/97       4,811.00            7235
                                                              ------------

   1      Double  Mirror   Focusing                               4,811.00
          System                                    7/15/97      19,400.00            6982
                                                              ------------

   1      Power    Mac     4400/200                              19,400.00
          32MB/2GB 12xCD                            7/8/97        1,715.00            7062
</TABLE>

                                  Page 1 of 3
<PAGE>

<TABLE>
<CAPTION>
QTY         EQUIPMENT                  PURCHASE ORDER   INVOICE NO.      CATALOG      SERIAL NO.          SUPPLIER/     PURCHASE
            DESCRIPTION                                                    NO.                             VENDOR         DATE
<S>    <C>                        <C>                  <C>               <C>          <C>               <C>             <C>
 1     64MB 168 Pin EDO DIMM                   971223      A4390761      CHP0397                N/A     Mac Warehouse    7/8/97
 1     4.3 GB Hard Drive                       971223                    DRH1753           17200652     Mac Warehouse    7/8/97
 1     Power User 17" Monitor                  971223                    MONO489          561011394     Mac Warehouse    7/8/97
 1     Ethernet Network Card                   971223                    DEC1652                N/A     Mac Warehouse    7/8/97

                                  971223 Total
 1     Octane,  SGI Workstation,               971225         71878                    0800690B713E     RCH Products     7/8/97
       $10000
 1     Dial and Button Box for                 971225         71878                            2443     RCH Products     7/8/97
       Octane
 1     ONC3/NFS for Irix                       971225         71878                             N/A     RCH Products     7/8/97
       Operating System
 1     ProDev C++ Bundle for                   971225          7187                             N/a     RCH Products     7/8/97
       C++ Development
                                  971225 Total
 2     32MB 168 Pin DIMM 70 NS                 971256      A5164009      CHP0403                N/A     Mac Warehouse    7/29/97
 3     Power User 15" Monitor                  971256      A5007919      MON0488                        Mac Warehouse    7/24/97
 3     Ethermac PCI Card                       971256      A5007919      DEC2382                N/A     Mac Warehouse    7/24/97
       10Base-T
 1     32MB 168 Pin DIMM 70 NS                 971256      A5007919      CHP0403                N/A     Mac Warehouse    7/24/97
 1     SuperMac C500 603E/18OLT                971256      A5040555      CPU0672    50N30A721000364     Mac Warehouse    7/24/97
       16MB 1.2 GB
 1     SuperMac C500 603E/18OLT                971256      A5040555      CPU0672    50N30A721000119     Mac Warehouse    7/24/97
       16MB 1.2GB
 1     SuperMac C500 603E/18OLT                971256      A5040555      CPU0672    50N30A723000615     Mac Warehouse    7/24/97

                                  971256 Total
 1     Laboratory Table,                       971277          5831                             N/A     LF Systems       8/21/97
       Stainless w/Blk Top                                                                              Corp
                                  971277 Total
 1     LCQ MS/DS System                        971317  S-021842-011        LCQ             LC000472     Finigan MAT      8/12/97
 1     ESI  Probe  for  the  LCQ               971317  S-021842-011        201A                 N/A     Finigan MAT      8/12/97
       MS/DS
 1     APCI  Probe  for  the LQC               971317  S-021842-011        201B                 N/A     Finigan MAT      8/12/97
       MDS/DS
                                  971317 Total
 1     Stereo Emitter & Glasses                971322         71888                           45542     RCH Products     7/16/97
                                  971322 Total
 1     NB Scientific                           971393  278404073197     14-280-15         790454146     Fischer          7/29/97
       Reciprocating Water Bath                                                                         Scientific
 1     Water Bath Gable Cover                  971393  278404073197     14-280-28               N/A     Fisher           7/29/97
                                                                                                        Scientific
                                  971393 Total
 1     Powerbook      1400CS/117               971460      A5462593      CPU0522       SQF7020JXBJX     Mac Warehouse    8/5/97
       12/750MB
 1     24MB  Memory  Module  for               971460      A5472220      CHP0411                N/A     Mac Warehouse    8/5/97
       Powerbook 140
 1     Apple  Powerbook  1400 8X               971460      A5472220      ACC2788                N/A     Mac Warehouse    8/5/97
       CD-ROM Module
 1     Etertech Ethernet Card                  971460      A5472220      ACC2482                N/A     Mac Warehouse    8/5/97

                                  971460 Total
 1     SuperMac C500  603E/18OLT               971461      A5501606      CPU0672    50N30A725001694     Mac Warehouse    8/6/97
       16MB/1.2GB
 1     Monitor Power User 15"                  971461      A5501606      MONO488                        Mac Warehouse    8/6/97

<CAPTION>
QTY         EQUIPMENT                  EQUIPMENT         PAID-CHECK #
            DESCRIPTION                   COST
<S>    <C>                            <C>                <C>
 1     64MB 168 Pin EDO DIMM              395.00            7062
 1     4.3 GB Hard Drive                  999.00            7062
 1     Power User 17" Monitor             430.00            7062
 1     Ethernet Network Card              122.00            7062
                                      ----------
                                        3,661.00
 1     Octane,  SGI Workstation,       58,446.00            6967
       $10000
 1     Dial and  Button  Box for        2,250.00            6967
       Octane
 1     ONC3/NFS for Irix                  595.00            6967
       Operating System
 1     ProDev C++ Bundle for            5,500.00            6967
       C++ Development
                                      ----------
                                       66,791.00
 2     32MB 168 Pin DIMM 70 NS            330.00
 3     Power User 15" Monitor             795.00            7104
 3     Ethermac PCI Card                  180.00            7104
       10Base-T
 1     32MB 168 Pin DIMM 70 NS            165.00            7104
 1     SuperMac C500  603E/18OLT          949.00            7104
       16MB 1.2 GB
 1     SuperMac C500  603E/18OLT          949.00            7104
       16MB 1.2GB
 1     SuperMac C500 603E/18OLT           949.00            7104
                                      ----------
                                        4,317.00
 1     Laboratory Table,                1,129.00            7235
                                      ----------
       Stainless w/Blk Top
                                        1,129.00
 1     LCQ MS/DS System               143,200.00            7239
 1     ESI  Probe  for  the  LCQ       10,000.00            7239
       MS/DS
 1     APCI  Probe  for  the LQC       10,000.00            7239
                                      ----------
       MDS/DS
                                      163,200.00
 1     Stereo Emitter & Glasses           990.00            6967
                                      ----------
                                          990.00
 1     NB Scientific Reciprocating      2,700.00            7093
       Water Bath
 1     Water Bath Gable Cover             412.00            7093
                                      ----------
                                        3,112.00

 1     Powerbook      1400CS/117        1,645.00            7184
       12/750MB
 1     24MB  Memory Module for            185.00            7184
       Powerbook 140
 1     Apple Powerbook 1400 8X            185.00            7184
       CD-ROM Module
 1     Etertech Ethernet Card              85.00            7184
                                      ----------
                                        2,100.00

 1     SuperMac C500  603E/18OLT          930.00            7184
       16MB/1.2GB
 1     Monitor Power User 15"             265.00            7184
                                      ----------
</TABLE>

                                   Page 2 o3
<PAGE>

<TABLE>
<CAPTION>
QTY          EQUIPMENT               PURCHASE ORDER      INVOICE NO.    CATALOG NO.       SERIAL NO.         SUPPLIER/
            DESCRIPTION                                                                                       VENDOR
<S>    <C>                         <C>                  <C>             <C>               <C>              <C>
                                   971461 Total
 1     Printer, Epson, Stylus                   971500      A5621438      PR11948           2UUX0012670    Micro
       1500 Wide Carriage                                                                                  Warehouse
 1     Monitor, Hitachi, 21"                    971500      A5621438      MON0362             G6H005057    Micro
                                                                                                           Warehouse
 1     CPU, Compaq Deskpro 6000                 971500      A5621438       CP5024         S6719BPP2Q430    Micro
                                                                                                           Warehouse
 1     64MB Memory Module for                   971500      A5796362       MY6945                   N/A    Micro
       Deskpro                                                                                             Warehouse
                                   971500 Total
 1     Oil Free Diaphragm Pump,                 971504           333       696244           20062616-97    Vacuubrand,
       Chem(PTFE)                                                                                          Inc.
 1     Incubator, Isotemp 5.0                   971543  278404083197     11690650D             70800248    Fisher
       Cu Ft                                                                                               Scientific
                                   971543 Total
 1     Analytical Balance                       971557  278404083197    01-913-503B          1116283226    Fisher
                                                                                                           Scientific
                                   971557 Total
 1     Lab Fit-out Work - Phase 1               979999        6/10/97                               N/A    Eagleview
                                                                                                           Constri.
 1     Lab Fit-out Work - Phase 2               979999             9/16/97                          N/A    Eagleview
                                                                                                           Constr.
                                   979999 Total
 1     SuperMac             C500                971725      A6776926      CPU0787       50N30A728002565    Mac Warehouse
       603LT/18OLT 16MB
 1     Monitor Power User 15"                   971725      A6776926      MONO488                          Mac Warehouse
 1     32MB 168 Pin DIMM                        971725      A6791693      RDR12126                  N/A    Mac Warehouse
       Memory Module
 1     Zip Drive SCSI                           971725      A6791693      CHP0403                   N/A    Mac Warehouse

                                   971725 Total
 1     Ultra Wide SCSI Disk                     971756         71942      RCH/E412             JK134135    RCH Products
       Drive System, 4.3GB
 1     Ultra Wide SCSI Disk                     971756         71942      RCH/E412             JK158471    RCH Products
       Drive System, 4.3GB
                                   971756 Total
                                                        Grand Total    N/A - NOT APPLICABLE
                                                                       SERIAL NUMBERS FOR MONITORS WILL BE FORWARD -
                                                                       NOT CURRENTLY AVAILABLE

<CAPTION>
QTY          EQUIPMENT                PURCHASE      EQUIPMENT     PAID - CHECK #
            DESCRIPTION                 DATE           COST
<S>    <C>                            <C>
                                                     1,195.00
 1     Printer, Epson, Stylus           8/8/97         469.00         7184
       1500 Wide Carriage
 1     Monitor, Hitachi, 21"            8/8/97       1,665.00         7184

 1     CPU, Compaq Deskpro 6000         8/8/97       3,149.00         7184

 1     64MB Memory Module for           8/8/97                        7184
       Deskpro                                         405.00
                                                  -------------
                                                     5,688.00
 1     Oil Free Diaphragm Pump,         8/28/97      1,965.00         7237
       Chem(PTFE)
 1     Incubator, Isotemp 5.0           8/14/97                       7242
       Cu Ft                                         1,192.53
                                                  -------------
                                                     1,192..53
 1     Analytical Balance               8/15/97      2,250.00         7242
                                                  -------------
                                                     2,250.00
 1     Lab Fit-out Work - Phase 1       5/31/97     24,225.00         6660

 1     Lab Fit-out Work - Phase 2       8/31/97    178,310.00         7241
                                                  -------------
                                                   202,535.00
 1     SuperMac             C500        9/10/97        890.00         7243
       603LT/18OLT 16MB
 1     Monitor Power User 15"           9/10/97        255.00         7243
 1     32MB 168 Pin DIMM                9/10/97        140.00         7243
       Memory Module
 1     Zip Drive SCSI                   9/10/97         95.00         7243
                                                  -------------
                                                     1,380.00
 1     Ultra Wide SCSI Disk             9/16/97      1,045.00         7236
       Drive System, 4.3GB
 1     Ultra Wide SCSI Disk             9/16/97                       7236
       Drive System, 4.3GB                           1,045.00
                                                  -------------
                                                     2,090.00
                                                  -------------

                                                  $657,381.28
                                                  =============
</TABLE>

                                   Page 3 o3
<PAGE>

                      SCHEDULE TO MASTER LEASE AGREEMENT

                         Dated as of December 19, 1997

                                Schedule No. 3

Lessor Name & Mailing Address                Lessee Name & Mailing Address
Transamerica Business Credit Corporation     3-Dimensional Pharmaceuticals, Inc.
Riverway II                                  Eagleview Corporate Center
West Office Tower                            665 Stockton Drive, Suite 104
9399 West Higgins Road                       Exton, Pennsylvania 119341
Rosemont, Illinois  60018

     Equipment Location (if different than Lessee's address above):

     This Schedule covers the following described equipment ("Equipment"):

            See Exhibit II attached hereto and made a part hereof.

     The Equipment is hereby leased pursuant to the provisions of the Master
Lease Agreement between the undersigned Lessee and Lessor dated June 12, 1997
(the "Master Lease"), the terms of which are incorporated herein by reference
thereto, plus the following additional terms, provisions, and modifications. The
Lessor reserves the right to adjust the monthly payments in accordance with the
Commitment Letter dated May 9, 1997, if the Lessor has not received this
Schedule and an Acceptance and Delivery Certificate executed by the Lessee
within five business days from the date first set forth above.

<TABLE>
<S>                                                                                  <C>
1.   Term (Number of Months)                                                         48 months
2.   Equipment Cost                                                                  $308,762.00
3.   Commencement Date                                                               December 30, 1997
4.   Rate Factor                                                                     2.5226% of Equipment Cost

5.   Total Rents                                                                     $373,86.80

6.   Advance Rents (first and last)                                                  $15,577.70

7.   Monthly rental payments                                                         $  7,788.85

     And the second such rental payments will be due on and                          January 1, 1998
     subsequent rental payments will be due on the same day of
     each month thereafter

8.   Security Deposit                                                                None

9.   In addition to the monthly rental payments  provided for herein,                $519.86
     Lessee shall pay to Lessor, as interim rent, payable on the commencement
     date specified above, an amount equal to 1/30th of the monthly rental
     payment (including monthly sales/use tax) multiplied by the number of days
     from and including the commencement date through the end of the same
     calendar month
</TABLE>

     Lessee hereby irrevocably authorizes Lessor to insert in this Schedule the
Commencement Date and the due date of the first rental payment.

                                                                     Page 1 of 3
<PAGE>

     Except as expressly provided or modified hereby, all the terms and
provisions of the Master Lease Agreement shall remain in full force and effect.

     The Purchase Date shall be December 1, 2001.

     The Stipulated Loss Value of any items of Equipment shall be an amount
equal to the present value of all future Rent discounted at a rate of 8% per
annum plus the Reversionary Value.

     The Reversionary Value of any item of Equipment shall be 10% of Equipment
Cost.

TRANSAMERICA BUSINESS CREDIT             3-DIMENSIONAL PHARMACEUTICALS, INC.
CORPORATION                              (Lessee)
(Lessor)

By: /s/ Robert D. Pomeroy, Jr.           By: /s/ Scott Horvitz
   ----------------------------------       ----------------------------------

Title: Executive Vice President          Title:  VP Finance
      -------------------------------          -------------------------------

                                                         Page 2 of 3
<PAGE>

                                    RIDER I
                               TO SCHEDULE NO. 1
TO:
X    Schedule to Master lease Agreement
X    UCC

         Equipment Location:      3-Dimensional Pharmaceuticals, Inc.
                                  665 Stockton Drive, Suite 104
                                  Exton, PA  19341

<TABLE>
<CAPTION>
QTY         EQUIPMENT DESCRIPTION               PURCHASE   INVOICE     CATALOG             SERIAL NO.       SUPPLIER/ VENDOR
                                                  ORDER       NO.        NO.
<S>  <C>                                     <C>           <C>         <C>            <C>                   <C>
 1   Robotic Workstation (see attached)            970728                  7413       See Invoice           Sagian
                                             970728 Total

 1   AccuCleave-96 Cleavage Station                971206             9700164 AC 96   00106                 Irori
                                             971206 Total

 1   Speedvac Component System                     971985             145663SS22      SC210A-7J440745-1H    Savant
                                                                                                            Instruments
                                             971985 Total

 1   O2  Workstation, 175 MHz, R10000              972101    71983    RCH/0210        0800690C5B20          RCH Products
 1   O2  Workstation, 175 MHz, R10000              972101    71983    RCH/0210        0800690C5B20          RCH Products
 1   Indigo2, R10000 High Impact Stereo            972101    71983    RCH/0210        0800690B9B92          RCH Products
                                             972101 Total

 1   Disk Drive, 9.1 GB, Fast/Wide                 972159    71989    RCH/19WDS       N/A                   RCH Products
 1   Disk Drive, 9.1 GB, Fast/Wide                 972159    71989    RCH/19WDS       N/A                   RCH Products
                                             972159 Total

                                              Grand Total

<CAPTION>
                                          X   Sale and Leaseback Agreement
                                          X   Bill of Sale

QTY         EQUIPMENT DESCRIPTION             PURCHASE          EQUIPMENT      PAID -
                                                DATE              COST         CHECK #
<S>  <C>                                      <C>             <C>              <C>
 1   Robotic Workstation (see attached)                       $2,111,495.00     7745
                                                              -------------
                                                                $211,495.00

 1   AccuCleave-96 Cleavage Station            10/1/97             8,200,00     7752
                                                              -------------
                                                                   8,200.00

 1   Speedvac Component System                11/20/97            10,588.00     7754
                                                              -------------
                                                                  10,588.00

 1   O2  Workstation, 175 MHz, R10000          11/4/97            18,734.00     7700
 1   O2  Workstation, 175 MHz, R10000          11/4/97            18,734.00     7700
 1   Indigo2, R10000 High Impact Stereo        11/4/97            38,097.00     7700
                                                              -------------
                                                                  75,565.00

 1   Disk Drive, 9.1 GB, Fast/Wide             11/3/97             1,457.00     7700
 1   Disk Drive, 9.1 GB, Fast/Wide             11/3/97             1,457.00     7700
                                                              -------------
                                                                   2,914.00

                                                              -------------
                                                                $308,762.00
                                                              =============
</TABLE>

================================================================================
Transamerica Business Credit Corporation      3-Dimensional Pharmaceutical, Inc.

BY: /s/ Robert D. Pomeroy, Jr.            BY: /s/ Scott Horvitz
    --------------------------------          -----------------------

Title:  Executive Vice President          Title:  VP Finance
      ------------------------------            ----------------------

                                                         Page 1 of 3
<PAGE>

                       ACCEPTANCE AND DELIVERY CERTIFICATE

3-Dimensional Pharmaceuticals, Inc., as lessee ("Lessee") under the Master Lease
Agreement dated as of June 12, 1997 between Lessee and Transamerica Business
Credit Corporation, as Lessor, does hereby acknowledge the acceptance and
delivery of the equipment listed in Lease Schedule No. 3, such acceptance and
delivery having been made on the 30th day of December, 1997.

                                          3-Dimensional Pharmaceuticals, Inc.

                                          By: /s/ Scott Horvitz
                                              -----------------------
                                           Name:     Scott Horvitz
                                           Title: Vice President

                                                         Page 1 of 3
<PAGE>

                              PAY PROCEEDS LETTER

December 19, 1997

Transamerica Business Credit Corporation
Riverway 11 - West Office Tower
9399 West Higgins Road
Rosemont,  IL  60018

Ladies and Gentlemen:

               Reference is made to the Master Lease Agreement, dated as of June
12, 1997, and Schedule No. 3, dated as of December 19, 1997, and executed by the
undersigned as Lessee and Transamerica Business Credit Corporation ("Lessor").

The undersigned authorizes and directs Lessor to disburse the proceeds of the
lease as follows:

     Payee                                                                Amount
     -----                                                                ------
1.   Bank Name:                     PNC Bank                         $292,664.44
     Bank Address:                  Philadelphia, PA
     ABA Number:                    0310-0005-3
     For account of:                3-Dimensional Pharmaceutical
     Account Number:                85-110-740-24
     Further Credit to:             Acct. #42-43-213-2042967
     Attention:                     Rosa Fernandez
     Telephone No.:                 908-220-3358

2.   Transamerica Business Credit                                     $16,097.56

                                               TOTAL:                $308,762.00

                                          3-DIMENSIONAL PHARMACEUTICALS, INC.

                                          By: /s/ Scott Horvitz
                                              -----------------
                                           Name: Scott Horvitz
                                           Title: VP Finance

                                                         Page 1 of 3
<PAGE>

                         SALE AND LEASEBACK AGREEMENT

          THIS SALE AND LEASEBACK AGREEMENT (this "Agreement"), is made as of
December 30, 1997, among 3-Dimensional Pharmaceuticals, Inc., a Delaware
corporation ("Seller"), and Transamerica Business Credit Corporation, a Delaware
corporation ( "Buyer").

                             W I T N E S S E T H :
                             - - - - - - - - - -

          WHEREAS, Seller is the owner of the equipment more particularly
described on Exhibit II hereto (the "Equipment");

          WHEREAS, Seller desires to sell to Buyer and Buyer desires to purchase
from Seller the Equipment; and

          WHEREAS, Buyer, as a condition to such purchase, wishes to lease to
Seller and Seller wishes to lease from Buyer the Equipment under the terms and
conditions of the Master Lease Agreement dated as of June 12, 1997 and Schedule
No. 3 thereto (collectively, as amended, supplemented or otherwise modified from
time to time, the "Lease") between Buyer, as lessor, and Seller, as lessee.

          NOW, THEREFORE, in consideration of the premises herein contained and
other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties hereto hereby agree as follows:

          1.   Amount and Terms of Purchase.
               ----------------------------

               (a)  Subject to the terms and conditions of this Agreement, and
in reliance upon the representations and warranties of the Seller herein set
forth, the Buyer agrees to purchase all of the Seller's right, title and
interest in and to all of the Equipment such that the Buyer will become the
owner of all such Equipment for all purposes whatsoever. The Seller hereby
agrees that the Buyer is under no obligation to purchase any other equipment now
or in the future and shall not assert a claim that the Buyer may have any such
obligation.

               (b)  The price to be paid by the Buyer with respect to the
purchase of the Equipment (the "Purchase Price") is $'308,762-00. The Purchase
Price shall be payable to the Seller on the Lease Commencement Date (as defined
in the Lease).

               (c)  The Seller shall pay any and all applicable federal, state,
county or local taxes and any and all present or future taxes or other
governmental charges arising in connection with the sale of the Equipment
hereunder, including sales, use or occupation taxes due upon the purchase by the
Buyer.

                                                         Page 1 of 3
<PAGE>

               (d)  The purchase of the Equipment shall be evidenced by a bill
of sale, substantially in the form attached hereto as Exhibit A (the "Bill of
Sale"), duly executed by the Seller.

          2.   Conditions to Purchase. The obligation of the Buyer to purchase
               ----------------------
the Equipment is subject to the following conditions:

               (a)  The Buyer shall have received this Agreement, duly executed
by the Seller.

               (b)  The Buyer shall have received the Bill of Sale, duly
executed by the Seller.

               (c)  The Buyer shall have received the Lease, duly executed by
the Seller.

               (d)  The Buyer shall have received resolutions of the Board of
Directors of the Seller approving and authorizing the execution, delivery and
performance by the Seller of this Agreement, the Lease and the notices and other
documents to be delivered by the Seller hereunder and thereunder (collectively,
the "Sale and Leaseback Documents").

               (e)  The Buyer shall have received the certificate of title or
similar evidence of ownership with respect to each item of Equipment and Uniform
Commercial Code financing statements covering the Equipment in form and
substance satisfactory to the Buyer, duly executed by the Seller.

               (f)  No material adverse change has occurred with respect to the
business, prospects, properties, results of operations, assets, liabilities or
condition (financial or otherwise) of the Seller and its affiliates, taken as a
whole, since December 31, 1996.

               (g)  The Buyer shall have received all warranties and other
documentation received or executed by Seller in connection with the original
acquisition of the Equipment by the Seller (and by its execution hereof the
Seller hereby assigns to the Buyer all such warranties and other Documentation).

               (h)  The Buyer shall have received such other approvals, opinions
or documents as the Buyer may reasonably request.

          3.   Representation and Warranties. To induce the Buyer to enter into
               -----------------------------
this Agreement, the Seller represents and warrants to the Buyer that:

               (a)  The Seller is duly authorized to execute, deliver and
perform its obligations under each of the Sale and Leaseback Documents and all
corporate action required on its part for the due execution, delivery and
performance of the transactions contemplated herein and therein has been duly
and effectively taken.

                                                                       Page 2 o3
<PAGE>

               (b)  The execution, delivery and performance by the Seller of
each of the Sale and Leaseback Documents and the consummation of the
transactions contemplated herein and therein does not and will not violate any
material provision of, or result in a material default under, the Seller's
Articles or Certificates of Incorporation or By-laws or any indenture or
agreement to which the Seller is a party or to which its assets are bound or any
order, permit, law, statute, code, ordinance, rule, regulation, certificate or
any other requirement of any governmental authority or regulatory body to which
the Seller is subject, or result in the creation or imposition of any mortgage,
deed of trust, pledge, security interest, lien or encumbrance of any kind upon
or with respect to the Equipment or any proceeds thereof, other than those in
favor of the Buyer as contemplated by the Sale and Leaseback Documents.

               (c)  No authorization or approval or other action by, and no
notice to or filing with, any governmental authority or regulatory body is
required for the due execution, delivery and performance by the Seller of any of
the Sale and Leaseback Documents to which it is a party.

               (d)  Each Sale and Leaseback Document to which the Seller is a
party constitutes or will constitute, when delivered hereunder, the legal, valid
and binding obligation of the Seller enforceable against the Seller in
accordance with its respective terms, except as such enforceability may be (i)
limited by the effect of applicable bankruptcy, insolvency, reorganization or
similar laws affecting the enforcement of creditors' rights generally or (ii)
subject to the effect of general principles of equity (regardless of whether
such enforceability is considered in a proceeding at equity or at law).

               (e)  There are no actions, suits, or proceedings pending, or, to
the Seller's knowledge, threatened against or affecting the Seller which seek to
enjoin, prohibit or restrain the consummation of any of the transactions
contemplated hereby or by the other Sale and Leaseback Documents.

               (f)  Each item of Equipment is owned by the Seller free and clear
of any liens and encumbrances of any kind or description. Upon purchase of the
Equipment hereunder, the Buyer will acquire good and marketable title in and to
the Equipment.

All representations and warranties herein shall survive the execution of this
Agreement and the purchase of the Equipment.

          4.   Indemnities. The Seller agrees to indemnify, defend, and save
               -----------
harmless the Buyer and its officers, directors, employees, agents, and
attorneys, and each of them (the "Indemnified Parties"), from and against all
claims, actions, suits, and other legal proceedings, damages, costs, interest,
charges, counsel fees and other expenses and penalties (collectively, the
"Indemnified Amounts") which any of the Indemnified Parties may sustain or incur
by reason of or arising out of (i) the Seller's ownership of any Equipment prior
to the date on which such Equipment is sold to the Buyer, or the Seller's acts
or omissions prior to such date under, in connection with or relating to such
Equipment or any of the Sale and Leaseback Documents, (ii) the operation,
maintenance or use of such Equipment prior to such date, (iii) any material
inaccuracy of any of the Seller's representations or warranties contained in any
of the Sale and

                                                                       Page 3 o3
<PAGE>

Leaseback Documents, (iv) the breach of any of the Seller's covenants contained
in any of the Sale and Leaseback Documents, (v) any loss or damage to any
Equipment in excess of the deductible which is not paid by insurance or (vi) any
sales, use, excise and other taxes, charges, and fees (including, without
limitation, income, franchise, business and occupation, gross receipts, sales,
use, licensing, registration, titling, personal property, stamp and interest
equalization taxes, levies, imposts, duties, charges or withholdings of any
nature), and any fines, penalties or interest thereon, imposed or levied by any
governmental body, agency or tax authority upon or in connection with the
Equipment, its acquisition, ownership, delivery, leasing, possession, use or
relocation or otherwise in connection with the transactions contemplated by each
Sale and Leaseback Document, but excluding taxes on or measured by the net
income of the Buyer. Notwithstanding the foregoing, Seller shall have no
obligation to indemnify Buyer for any Indemnified Amounts which arise out of
Buyer's gross negligence or willful misconduct.

          5.   Remedies. Upon the Seller's receipt of notice from the Buyer of
               --------
Seller's violation of or default under any provision of this Agreement, the
Buyer may (subject to the provisions of the other Sale and Leaseback Documents
and after all applicable grace periods) proceed to protect and enforce its
rights either by suit in equity or by action at law or both, whether for the
specific performance of any covenant or agreement contained herein or in aid of
the exercise of any power granted in any Sale and Leaseback Document; it being
intended that the remedies contained in any Sale and Leaseback Document shall be
cumulative and shall be in addition to every other remedy given under such Sale
and Leaseback Document or now or hereafter existing at law or in equity or by
statute or otherwise.

          6.   Amendments, etc. No amendment or waiver of any provision of this
               ---------------
Agreement, nor consent to any departure therefrom, shall in any event be
effective unless the same shall be in writing and signed by the Buyer and the
Seller, and then such waiver or consent shall be effective only in the specific
instance and for the specific purpose for which given.

          7.   Notices, etc. All notices and other communications provided for
               ------------
hereunder shall be in writing and sent:

                           if to the Seller, at its address at:

                           3-Dimensional Pharmaceuticals, Inc.
                           Eagleview Corporate Center
                           665 Stockton Drive, Suite 104
                           Exton, Pennsylvania 19341
                           Attention: Chief Financial Officer
                           Telephone No.: (610) 458-6043
                           Telecopy No.: (610) 458-8258

                           if to the Buyer, at its address at:

                           Transamerica Business Credit Corporation
                           Technology Finance Division
                           76 Batterson Park Road

                                                                       Page 4 o3
<PAGE>

                           Farmington, Connecticut 06032-2571
                           Attention: Assistant Vice President,
                           Lease Administration
                           Telephone No.: (860) 677-6466
                           Telecopy No.: (860) 677-6766

                           with a copy to:

                           Transamerica Business Credit Corporation
                           9399 West Higgins Road
                           Rosemont, Illinois 60018
                           Attention: Legal Department
                           Telephone No.: (847) 685-1106
                           Telecopy No.: (847) 685-1143

or to such other address as shall be designated by such party in a written
notice to the other party. All such notices shall be deemed given (i) if sent by
certified or registered mail, three days after being postmarked, (ii) if sent by
overnight delivery service, when received at the above stated addresses or when
delivery is refused and (iii) if sent by facsimile transmission, when receipt of
such transmission is acknowledged.

          8.   No Waiver; Remedies. No failure on the part of the Buyer to
               -------------------
exercise, and no delay in exercising, any right hereunder shall operate as a
waiver thereof, nor shall any single or partial exercise of any such right
preclude any other or further exercise thereof or the exercise of any other
right. The remedies herein provided are cumulative and not exclusive of any
remedies provided by law.

          9.   Benefit. Neither party may transfer, assign or delegate any of
               -------
its rights, duties or obligations hereunder without the prior written consent of
the other party.

          10.  Binding Effect. This Agreement shall be binding upon and inure to
               --------------
the benefit of the Seller and the Buyer and their respective successors and
assigns.

          11.  GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND SHALL BE
               -------------
CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF ILLINOIS WITHOUT GIVING
EFFECT TO THE CONFLICTS OF LAW PRINCIPLES THEREOF.

          12.  Execution in Counterparts. This Agreement may be executed in any
               -------------------------
number of counterparts, each of which shall constitute an original and all of
which taken together shall constitute one and the same agreement.

          13.  Severability. If one or more of the provisions contained in this
               ------------
Agreement shall be invalid, illegal, or unenforceable in any respect, the
validity, legality, and enforceability of the remaining provisions contained
herein, and any other application thereof, shall not in any way be affected or
impaired thereby.

                                                                       Page 5 o3
<PAGE>

          14.  SUBMISSION TO JURISDICTION. ALL DISPUTES ARISING UNDER OR IN
               --------------------------
CONNECTION WITH THIS AGREEMENT BETWEEN THE PARTIES HERETO, WHETHER SOUNDING IN
CONTRACT, TORT, EQUITY OR OTHERWISE, SHALL BE RESOLVED ONLY BY STATE AND FEDERAL
COURTS LOCATED IN ILLINOIS, AND THE COURTS TO WHICH AN APPEAL THEREFROM MAY BE
TAKEN; PROVIDED, HOWEVER, THAT THE BUYER SHALL HAVE THE RIGHT, TO THE EXTENT
PERMITTED BY APPLICABLE LAW, TO PROCEED AGAINST THE SELLER OR ITS PROPERTY IN
ANY LOCATION REASONABLY SELECTED BY THE BUYER IN GOOD FAITH TO ENABLE THE BUYER
TO REALIZE ON SUCH PROPERTY, OR TO ENFORCE A JUDGMENT OR OTHER COURT ORDER IN
FAVOR OF THE BUYER. THE SELLER WAIVES ANY OBJECTION THAT IT MAY HAVE TO THE
LOCATION OF THE COURT IN WHICH THE BUYER HAS COMMENCED A PROCEEDING, INCLUDING,
WITHOUT LIMITATION, ANY OBJECTION TO THE LAYING OF VENUE OR BASED ON FORUM NON
CONVENIENS.

          15.  JURY TRIAL. THE PARTIES HERETO EACH HEREBY WAIVE TO THE FULLEST
               ----------
EXTENT PERMITTED BY LAW ANY RIGHT TO A TRIAL BY JURY IN ANY ACTION OR PROCEEDING
ARISING UNDER OR IN CONNECTION WITH THIS AGREEMENT.

                                                                       Page 6 o3
<PAGE>

          IN WITNESS WHEREOF, THE PARTIES HERETO HAVE CAUSED THIS Agreement to
be executed by their respective officers hereunto duly authorized, as of the
first date written above.

                               3-DIMENSIONAL PHARMACEUTICALS, INC.

                               By: /s/ Scott Horvitz
                                   ----------------------------------
                                Name: Scott Horvitz
                                Title:  Vice President, Finance and Admin

                               TRANSAMERICA BUSINESS CREDIT CORPORATION

                               By: /s/ Robert D. Pomeroy, Jr.
                                   ----------------------------------
                                Name: Robert D. Pomeroy, Jr.
                                Title: Executive Vice President

Exhibit II - Equipment
Exhibit A - Bill of Sale

                                                                       Page 7 o3
<PAGE>

                                   EXHIBIT A

                                 BILL OF SALE

          KNOW ALL PERSONS BY THESE PRESENTS 3-Dimensional Pharmaceuticals, Inc.
(the "Seller"), for _________________________________________________________
and 00/100 Dollars ($__________) and other valuable consideration to it in hand
paid, receipt of which is hereby acknowledged, does unconditionally, absolutely
and irrevocably grant, sell, assign, transfer and convey unto TRANSAMERICA
BUSINESS CREDIT CORPORATION and its assignees or successors (collectively, the
"Buyer"), all of the Seller's right, title and interest in and to the equipment
described on Exhibit II hereto (collectively, the "Equipment").

          TO HAVE AND TO HOLD said Equipment unto the said Buyer, to and for its
use forever.

          AND, the Seller hereby warrants, covenants and agrees that it (a) has
good and marketable title to the Equipment, free and clear of any liens and
other encumbrances; and (b) will warrant and defend the sale of the Equipment
against any and all persons claiming against such title.

          IN WITNESS WHEREOF the Seller has caused this instrument to be duly
executed and delivered as of this ____ day of _________________  1997.

                              3-DIMENSIONAL PHARMACEUTICALS, INC.

                              By:
                              Name:
                              Title:

                                                                       Page 1 o3
<PAGE>

                                 BILL OF SALE

          KNOW ALL PERSONS BY THESE PRESENTS 3-Dimensional Pharmaceuticals, Inc.
(the "Seller"), for Three Hundred Eighty Thousand, Seven Hundred Sixty Two
and 00/100 Dollars ($309,762.00) and other valuable consideration to it in hand
paid, receipt of which is hereby acknowledged, does unconditionally, absolutely
and irrevocably grant, sell, assign, transfer and convey unto TRANSAMERICA
BUSINESS CREDIT CORPORATION and its assignees or successors (collectively, the
"Buyer"), all of the Seller's right, title and interest in and to the equipment
described on Exhibit II hereto (collectively, the "Equipment").

          TO HAVE AND TO HOLD said Equipment unto the said Buyer, to and for its
use forever.

          AND, the Seller hereby warrants, covenants and agrees that it (a) has
good and marketable title to the Equipment, free and clear of any liens and
other encumbrances; and (b) will warrant and defend the sale of the Equipment
against any and all persons claiming against such title.

          IN WITNESS WHEREOF the Seller has caused this instrument to be duly
executed and delivered as of this 30/th/ day of December, 1997.

                              3-DIMENSIONAL PHARMACEUTICALS, INC.

                              By: /s/ Scott Horvitz
                                  --------------------------
                               Name:
                               Title:

                                                                       Page 1 o3

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