Document:

Stock Option Agreement between Inspire Pharmaceuticals, Inc.

  
 Exhibit 10.2

 STOCK OPTION AGREEMENT 
 THIS AGREEMENT (this “Agreement”) is made effective this 15th day of September, 2010 (the “Date of Grant”) by and between Inspire Pharmaceuticals, Inc.,
a Delaware corporation (the “Company”), and Charles A. Johnson (the “Grantee” or “Executive”). 
 WHEREAS, in connection with the Executive Employment Agreement, dated August 12, 2010, by and between the Company and the Grantee (the “Executive Employment Agreement”), the
Company agreed to grant to the Grantee an option to purchase shares of common stock of the Company (the “Company Stock”) as an inducement to Grantee to accept employment with the Company as the Company’s Executive Vice
President of Research and Development and Chief Medical Officer; and 
 WHEREAS, the Compensation Committee of the Board
of Directors of the Company (the “Committee”) has authorized the Company to grant the Option (as defined below) as an inducement grant to the Executive outside of the Company’s Amended and Restated 2010 Equity Compensation
Plan consistent with Nasdaq Marketplace Rule 5635(c)(4). 
 NOW, THEREFORE, the parties to this Agreement, intending to
be legally bound hereby, agree as follows: 
 1. Grant of Option. Subject to the terms and conditions set forth in this Agreement,
the Company hereby grants to the Grantee a nonqualified stock option (the “Option”) to purchase 250,000 shares of the Company Stock at an exercise price of $5.11 per share (the “Exercise Price”). The
Option shall become exercisable according to Paragraph 2 below. Except as otherwise specifically set forth herein, capitalized terms contained in this Agreement shall have the respective meanings given to them in the Executive Employment
Agreement and shall survive the termination of the Executive Employment Agreement. 
 2. Exercisability of Option. 

(a) The Option shall become exercisable in the manner provided below, if the Grantee is Employed by the Employer (as defined
in Paragraph 9) on the applicable date. For this purpose, the term “Shares” refers to the number of shares underling that portion of the Option that vests in the manner described under Vest Type and Full Vest Date. The term
“Vest Type” describes how the Option covering those shares will vest before the Full Vest Date. For example, if Vest Type is “monthly”, that Option will vest with respect to those shares on a pro rata basis on each
monthly anniversary of the Date of Grant. The term “Full Vest Date” is the date on which that portion of the Option covering all of the corresponding shares set forth in the “Shares” column will be fully
vested. 
  

					
	 Shares
	 	 Vest Type
	 	 Full Vest Date

	 62,500
	 	Annual	 	
1st Anniversary of Date of Grant

			
	 187,500
	 	 Monthly
 (vesting ratably on a monthly basis over the next three years following the
1st anniversary of the Date of Grant)
	 	
4th Anniversary of Date of Grant

 Each portion of the Option shall
become exercisable upon the date that it becomes vested and nonforfeitable. 

  
 (b) The
exercisability of the Option is cumulative, but shall not exceed one hundred percent (100%) of the Shares subject to the Option. If the foregoing schedule would produce fractional Shares, the number of Shares for which the Option becomes
exercisable shall be rounded down to the nearest whole Share. 
 (c) If there is any change in the number or kind of
shares of Company Stock outstanding (i) by reason of a stock dividend, spin-off, recapitalization, stock split, or combination or exchange of shares; (ii) by reason of a merger, reorganization or consolidation; (iii) by reason of a
reclassification or change in par value; or (iv) by reason of any other extraordinary or unusual event affecting the outstanding Company Stock as a class without the Company’s receipt of consideration, or if the value of outstanding shares
of Company Stock is substantially reduced as a result of a spin-off or the Company’s payment of an extraordinary dividend or distribution, the price per share of the Option shall be appropriately adjusted by the Company to reflect any increase
or decrease in the number of, or change in the kind or value of, issued shares of Company Stock to preclude, to the extent practicable, the enlargement or dilution of rights and benefits under the Option; provided, however, that any fractional
shares resulting from such adjustment shall be rounded down to the nearest whole share. Any adjustments determined by the Company shall be final, binding, and conclusive. 
 3. Term of Option. The Option shall have a term of seven (7) years from the Date of Grant and shall terminate at the expiration of that period, unless it is terminated at an earlier
date pursuant to the provisions of this Agreement. In no event may the Option be exercised after the date that is immediately before the seventh (7th) anniversary of the Date of Grant. 
 4. Exercise Procedures. 
 (a) Subject to the provisions of
Paragraphs 2 and 3 above, the Grantee may exercise part or all of the exercisable Option by giving the Company written notice of intent to exercise in the manner provided in this Agreement, specifying the number of shares of Company Stock as to
which the Option is to be exercised. At such time as the Committee shall determine, the Grantee shall pay the exercise price (i) in cash, (ii) by payment through a broker in accordance with procedures permitted by
Regulation T of the Federal Reserve Board, or (iii) to the extent not in violation of Internal Revenue Code Section 409A by “net exercise” in which the number of shares of Company Stock that Grantee receives is reduced
by the number of shares required to satisfy his obligation to pay his exercise price and minimum income tax withholding. 

(b) The obligation of the Company to deliver shares of Company Stock upon exercise of the Option shall be subject to all
applicable laws, rules, and regulations and such approvals by governmental agencies as may be deemed appropriate by the Company, including such actions as Company counsel shall deem necessary or appropriate to comply with relevant securities laws
and regulations. The Company may require that the Grantee (or other person exercising the Option after the Grantee’s death) represent that the Grantee is purchasing shares of Company Stock for the Grantee’s own account and not with a view
to or for sale in connection with any distribution of the shares of Company Stock, or such other representations as the Company deems appropriate. 
 (c) All obligations of the Company under this Agreement shall be subject to the rights of the Company to withhold amounts required to be withheld for any taxes, if applicable. Subject to Committee
approval, the Grantee may elect, in a form and manner prescribed by the Company, to satisfy any tax withholding obligation of the Employer with respect to the Option by having shares of Company Stock withheld up to an amount that does not exceed the
minimum applicable withholding tax rate for federal (including FICA), state and local tax liabilities. 

  
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 5. Restrictions on
Exercise. Except as the Company may otherwise permit, only the Grantee may exercise the Option during the Grantee’s lifetime and, after the Grantee’s death, the Option shall be exercisable solely by the legal representatives of the
Grantee, or by the person who acquires the right to exercise the Option by will or by the laws of descent and distribution, to the extent that the Option is exercisable pursuant to this Agreement. Notwithstanding the foregoing, the Grantee may
transfer the Option to family members, or one (1) or more trusts or other entities for the benefit of or owned by family members, consistent with applicable securities laws, provided that the Grantee receives no consideration for the transfer
of the Option and the transferred Option shall continue to be subject to the same terms and conditions as were applicable to the Option immediately before the transfer. 
 6. Termination of Employment, Disability, or Death. 
 (a)
Except as provided below, the Option may only be exercised while the Grantee is Employed by the Employer. In the event that the Grantee ceases to be Employed by the Employer for any reason other than Disability, death, termination for Cause, or
as set forth in subparagraph (b), (c),(d), (e) or (f) below, the Option shall terminate unless exercised within 90 days after the date on which the Grantee ceases to be Employed by the Employer (or within such other longer period
of time as may be specified by the Company), but in any event no later than the date of expiration of the Option term. Except as otherwise provided herein or in the Executive Employment Agreement, any portion of the Option that is not otherwise
exercisable as of the date on which the Grantee ceases to be Employed by the Employer shall terminate as of such date. 
 (b) In the event the Grantee ceases to be Employed by the Employer on account of a termination by the Employer for Cause, the Option shall terminate as of the 30th day after the date on which the Grantee ceases to be Employed by the
Employer or the date on which the Option would otherwise expire, if earlier. 
 (c) In the event the Grantee ceases to be
Employed by the Employer because the Grantee is Disabled, except as otherwise provided in the Executive Employment Agreement, the unexercised outstanding portion of the Option shall become immediately exercisable and shall terminate unless exercised
within twelve (12) months after the date on which the Grantee ceases to be Employed by the Employer (or within such other period of time as may be specified by the Company), but in any event no later than the date of expiration of the
Option term. 
 (d) If the Grantee dies while Employed by the Employer, except as otherwise provided in the Executive
Employment Agreement, the unexercised outstanding portion of the Option shall become immediately exercisable and remain exercisable for a period of twelve (12) months from his date of death, but in no event later than the date of expiration of
the Option term. If the Grantee dies within 90 days after the date on which the Grantee ceases to be Employed by the Employer on account of a termination specified in subparagraph (a) above (or within such other period of time as may be
specified in the Executive Employment ), the portion of the Option that is otherwise exercisable by the Grantee shall terminate unless exercised within the twelve (12) month period after the date on which the Grantee ceases to be Employed by
the Employer (or within such other period of time as may be specified), but in any event no later than the date of expiration of the Option term. 
 (e) Notwithstanding anything herein to the contrary, in the event that the Executive’s employment is terminated by the Company without Cause or by the Executive with Good Reason, the
unexercised outstanding portion of the Option shall remain exercisable for a period of twelve (12) months from his termination of employment, but in no event later than the date of expiration of the Option term. 

  
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 (f) To the
extent that any Company-sponsored plan, policy or arrangement, or any agreement to which the Company is a party provides for a longer exercise period for the Option under applicable circumstances than the exercise period that is provided for in this
Paragraph 6 under those circumstances, then the exercise period set forth in such plan, policy, arrangement or agreement applicable to such circumstances shall apply in lieu of the exercise period provided for in this Paragraph 6.

 7. Change in Control. The provision of the Inspire Executive Change in Control Severance Benefit Plan (or successor plan, if
any), as in effect from time-to-time during the term of this Agreement, shall apply to the Option (it being understood that the Company may choose to terminate such plan without a successor plan being adopted). 

8. Requirements for Issuance or Transfer of Company Stock. No Company Stock shall be issued or transferred in connection with the grant
under this Agreement unless and until all legal requirements applicable to the issuance or transfer of such Company Stock have been complied with. This grant made shall be conditioned on the Grantee’s undertaking in writing to comply with such
restrictions on his subsequent disposition of such shares of Company Stock, and certificates representing such shares may be legended to reflect any such restrictions. Certificates representing shares of Company Stock issued or transferred under
this Agreement (or other evidence of ownership) will be subject to such stop-transfer orders and other restrictions as may be required by applicable laws, regulations and interpretations, including any requirement that a legend be placed thereon.

 9. Definitions. 
 (a) “Fair Market Value” per Share, or for the Company Stock, shall be determined as follows: (i) if the principal trading market for the Company Stock is a national
securities exchange or the Nasdaq National Market, the last reported sale price thereof on the relevant date or, if there were no trades on that date, the latest preceding date upon which a sale was reported; or (ii) if the Company Stock
is not principally traded on such exchange or market, the mean between the last reported “bid” and “asked” prices of Company Stock on the relevant date, as reported on Nasdaq or, if not so reported, as reported by the National
Daily Quotation Bureau, Inc. or as reported in a customary financial reporting service, as applicable and as the Company determines. If the Company Stock is not publicly traded or, if publicly traded, is not subject to reported
transactions or “bid” or “asked” quotations as set forth above, the Fair Market Value per share shall be as determined by the Company. 
 (b) “Employed by the Employer” shall mean employment as an employee of the Employer (so that, for purposes of exercising Options, the Grantee shall not be considered to have
terminated employment until the Grantee ceases to be an employee of the Employer). 
 (c) “Employer”
shall mean the Company and its parent and subsidiary corporations, as determined by the Board of Directors of the Company (the “Board”). 
 10. Administration. The Committee shall have the authority to interpret and construe the terms of this Agreement in a manner consistent with the terms of the Executive Employment Agreement.
Notwithstanding the foregoing, all determinations with regard to matters covered by the Executive Employment Agreement shall be resolved in accordance with the dispute resolution provisions provided therein and such resolutions shall be binding with
regard to such matters for purposes of this Agreement. 

  
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 11. Amendment of
Agreement. This Agreement may only be modified or amended in a writing signed by both parties. 
 12. Waiver. Either
party’s failure to enforce any provision or provisions of this Agreement shall not in any way be construed as a waiver of any such provision or provisions, nor prevent that party thereafter from enforcing each and every other provision of this
Agreement. The rights granted both parties herein are cumulative and shall not constitute a waiver of either party’s right to assert all other legal remedies available to it under the circumstances. 

13. Further Assurances. The Grantee agrees upon request to execute any further documents or instruments necessary or desirable to carry out
the purposes or intent of this Agreement. 
 14. No Employment or Other Rights. The grant of the Option hereunder shall not confer
upon the Grantee any right to be retained by, or to continue in, the employ of the Employer. 
 15. No Shareholder Rights. Neither
the Grantee, nor any person entitled to exercise the Grantee’s rights in the event of the Grantee’s death, shall have any of the rights and privileges of a shareholder with respect to the shares of Company Stock subject to the Option,
until certificates for shares of Company Stock have been issued upon the exercise of the Option. 
 16. Assignment and Transfers.
Except as otherwise provided herein or as the Committee may otherwise permit, the rights and interests of the Grantee under this Agreement may not be sold, assigned, encumbered or otherwise transferred except, in the event of the death of the
Grantee, by will or by the laws of descent and distribution. In the event of any attempt by the Grantee to alienate, assign, pledge, hypothecate, or otherwise dispose of the Option or any right hereunder, except as provided for in this Agreement, or
in the event of the levy or any attachment, execution or similar process upon the rights or interests hereby conferred, the Company may terminate the Option by notice to the Grantee, and the Option and all rights hereunder shall thereupon become
null and void. The rights and protections of the Company hereunder shall extend to any successors or assigns of the Company in connection with a sale of all or substantially all of the Company’s assets and to the Company’s parents,
subsidiaries and affiliates. 
 17. Compliance with Law. The exercise of Options and the obligations of the Company to issue or
transfer shares of Company Stock under the grant shall be subject to all applicable laws and to approvals by any governmental or regulatory agency as may be required. The Company may revoke the grant if it is contrary to law or modify the grant to
bring it into compliance with any valid and mandatory government regulation. 
 18. Applicable Law. The validity, construction,
interpretation and effect of this Agreement shall be governed by, and construed and enforced in accordance with, the laws of the State of North Carolina, without giving effect to the conflicts of laws provisions thereof. 

19. Notice. Any notice to the Company provided for in this Agreement shall be addressed to the Company in care of the Committee at
4222 Emperor Boulevard, Suite 200, Durham, North Carolina, 27703-8466, and any notice to the Grantee shall be addressed to such Grantee at the current address shown on the payroll of the Employer, or to such other address as a party may
designate to the other party in writing. Any notice shall be delivered by hand, sent by telecopy or enclosed in a properly sealed envelope addressed as stated above, deposited, postage prepaid, in a post office regularly maintained by the United
States Postal Service. 

  
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 20. Headings. Paragraph
headings are for reference only. In the event of a conflict between a title and the content of a Paragraph, the content of the Paragraph shall control. 
 21. Counterparts. This Agreement may be executed, including execution by facsimile signature, in one or more counterparts, each of which shall be deemed an original, and all of which
together shall be deemed to be one and the same instrument. 
 [Signature page to follow] 

  
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 IN WITNESS
WHEREOF, the Company has caused its duly authorized officer to execute this Agreement, and the Grantee has executed this Agreement, effective as of the Date of Grant. 

 

			
	INSPIRE PHARMACEUTICALS, INC.:
		
	By:	 	 /s/ Joseph M. Spagnardi

		
	Name:	 	 Joseph M. Spagnardi

		
	Title:	 	 SVP, General Counsel & Secretary

I hereby accept the Option described in this Agreement, and I agree to be bound by the terms of this Agreement. 

 

			
	GRANTEE:
		
	By:	 	 /s/ Charles A. Johnson

		
	Grantee:	 	 Charles A. Johnson

  
 - 7 -Restricted Stock Unit Agreement between Inspire Pharmaceuticals, Inc.

  
 Exhibit 10.3

 RESTRICTED STOCK UNIT AGREEMENT 
 THIS AGREEMENT (this “Agreement”) is made effective this 15th day of September, 2010 (the “Date of Grant”) by and between Inspire Pharmaceuticals, Inc.,
a Delaware corporation (the “Company”), and Charles A. Johnson (the “Grantee”). 
 WHEREAS, in connection with the Executive Employment Agreement, dated August 12, 2010, by and between the Company and the Grantee (the “Executive Employment Agreement”), the
Company agreed to grant to the Grantee 150,000 restricted stock units (the “Units” or the “Grant”) as an inducement to Grantee to accept employment with the Company as the Company’s Executive Vice
President of Research and Development and Chief Medical Officer; and 
 WHEREAS, the Compensation Committee of the Board
of Directors of the Company (the “Committee”) has authorized the Company to grant the Units as an inducement grant to the Executive outside of the Company’s Amended and Restated 2010 Equity Compensation Plan consistent
with Nasdaq Marketplace Rule 5635(c)(4). 
 NOW, THEREFORE, the parties to this Agreement, intending to be legally bound
hereby, agree as follows: 
 1. Grant of Restricted Units. The Company hereby grants to the Grantee 150,000 Units. Each Unit is
equivalent in value to one share of the common stock of the Company (the “Company Stock”), and shall entitle the Grantee to receive from the Company, subject to Section 2 of this Agreement, one share of Company Stock. Except as
otherwise specifically set forth herein, capitalized terms contained in this Agreement shall have the respective meanings given to them in the Executive Employment Agreement and shall survive the termination of the Executive Employment Agreement.

 2. Vesting of Units. The Units are subject to forfeiture to the Company until such time as they vest and become nonforfeitable
as set forth below in this Section 2. 
 (a) Units shall vest and become nonforfeitable in the manner provided
below, if the Grantee is Employed by the Employer (as defined below) on the applicable date. For this purpose, the term “Shares” refers to the number of shares underling that portion of the Units that vests in the manner described
under Vest Type and Full Vest Date. The term “Vest Type” describes how the Units covering those shares will vest before the Full Vest Date. For example, if Vest Type is “annual”, the Units will vest with respect to
those shares on a pro rata basis on each anniversary of the Date of Grant. The term “Full Vest Date” is the date on which that portion of the Grant covering all of the corresponding shares set forth in the
“Shares” column will be fully vested. 
  

					
	 Shares
	 	 Vest Type
	 	 Full Vest Date

	 37,500
	 	Annual	 	1st Anniversary of the Date of Grant
			
	 112,500
	 	 Annual
 (vesting ratably on an annual basis over the next three years following the
1st anniversary of the Date of Grant)
	 	4th Anniversary of the Date of Grant

  
 (b) Except as
otherwise provided herein or in the Executive Employment Agreement, the terms of which are deemed included herein and shall control in the event of any conflict, upon the Grantee’s Separation from Service (as defined in Section 11
hereof) with the Employer for Death or Disability, any Units which have not vested as of such date shall immediately vest. If the Grantee experiences a Separation from Service for any other reason, any Units which have not vested as of such date
shall immediately and automatically be forfeited. 
 (c) The issuance of the Company Stock underlying the Units that have
become vested and nonforfeitable (including the issuance of stock certificates evidencing the Common Stock) is subject to the satisfaction of any withholding obligations (including federal and state income, and FICA taxes), as described in
Section 3, below. 
 3. Delivery of Company Stock. Subject to Section 6.2 of the Grantee’s Executive Employment
Agreement and the Grantee’s satisfaction of any withholding obligations (including federal and state income, and FICA taxes) in connection with the Grantee’s receipt of any Units, as soon as administratively feasible following the
scheduled vesting date of such Units per Section 2(a) or sixty (60) days following an earlier vesting date that occurs as a result of the Grantee’s separation from service (the “Delivery Date”), the Grantee shall
receive stock certificates (or other appropriate documentation) evidencing the conversion of the vested Units into Company Stock. The Grantee’s withholding obligations, if any, shall be satisfied by making a payment to the Company in cash, by
personal check, or by a reduction of the number of Shares deliverable to the Grantee, at the Grantee’s election, in an amount sufficient to satisfy such withholding obligations. The withholding of the Units vesting shall be paid by reduction if
Grantee has not elected prior to the vesting date and made any cash payment due on or prior to the vesting date. Notwithstanding anything herein to the contrary, the Units shall be construed in a manner that would not result in an excise tax under
Section 409A of the Code as described in Section 6.2 of the Executive Employment Agreement which is incorporated herein by reference and shall survive the termination of the Executive Employment Agreement. 

4. Rights as Unit Holder. The Grantee shall not have voting or any other rights as a stockholder of the Company with respect to the Units.
Grantee shall have all of the rights and privileges of a holder of Company Stock with respect to the shares of Company Stock that he receives in satisfaction of his Units pursuant to this Agreement. 

5. Stock Splits, etc. If there is any change in the number or kind of shares of Company Stock outstanding (i) by reason of a stock
dividend, spin-off, recapitalization, stock split, or combination or exchange of shares; (ii) by reason of a merger, reorganization, or consolidation; (iii) by reason of a reclassification or change in par value; or (iv) by reason of
any other extraordinary or unusual event affecting the outstanding Company Stock as a class without the Company’s receipt of consideration, or if the value of outstanding shares of Company Stock is substantially reduced as a result of a
spin-off or the Company’s payment of an extraordinary dividend or distribution, the number of shares covered by this Grant, the kind of shares issued under this Grant shall be appropriately adjusted by the Company to reflect any increase or
decrease in the number of, or change in the kind or value of, issued shares of Company Stock to preclude, to the extent practicable, the enlargement or dilution of rights and benefits under this Grant; provided, however, that any fractional shares
resulting from such adjustment shall be rounded down to the nearest whole share. Any adjustments determined by the Company shall be final, binding, and conclusive. 
 6. Tax Consequences. The Grantee understands and agrees that the Company has not advised the Grantee regarding the Grantee’s income tax liability in connection with the vesting of the
Units. The Grantee has reviewed with the Grantee’s own tax advisors the federal, state, local 

  
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and foreign tax consequences of this investment and the transactions contemplated by this Agreement. The Grantee is relying solely on such advisors and not on any statements or representations of
the Company or any of its agents. The Grantee understands that, except as otherwise specifically provided in the Executive Employment Agreement, the Grantee (and not the Company) shall be responsible for the Grantee’s own tax liability that may
arise as a result of this investment or the transactions contemplated by this Agreement. 
 7. Restriction on Transfer. None of
the Units or any beneficial interest therein shall be transferred, encumbered, pledged or otherwise alienated or disposed of in any way except by will or by the laws of descent and distribution. 

8. Restrictive Legends. Stock certificates provided to the Grantee evidencing the Company Stock received hereunder shall bear such legends
as the Company deems necessary or desirable under the Securities Act of 1933, as amended (the “Securities Act”), or the rules or regulations promulgated thereunder. 
 9. Requirements for Issuance or Transfer of Shares. No Company Stock shall be issued or transferred in connection with the Grant under this Agreement unless and until all legal requirements
applicable to the issuance or transfer of such Company Stock have been complied with. This Grant made shall be conditioned on the Grantee’s undertaking in writing to comply with such restrictions on his subsequent disposition of such shares of
Company Stock, and certificates representing such shares may be legended to reflect any such restrictions. Certificates representing shares of Company Stock issued or transferred under this Agreement (or other evidence of ownership) will be subject
to such stop-transfer orders and other restrictions as may be required by applicable laws, regulations and interpretations, including any requirement that a legend be placed thereon. 
 10. Change in Control. The provision of the Inspire Executive Change in Control Severance Benefit Plan (or successor plan, if any), as in effect from time-to-time during the term of this
Agreement, shall apply to the Option (it being understood that the Company may choose to terminate such plan without a successor plan being adopted). 
 11. Definitions. 
 (a) “Separation from
Service” shall mean the date on which the Grantee experiences a separation from service with the Company as defined in Section 409A of the Code and the regulations promulgated thereunder. 

(b) “Employed by the Employer” shall mean employment as an employee of the Employer. 

(c) “Employer” shall mean the Company and its parent and subsidiary corporations, as determined by the Board of
Directors of the Company (the “Board”). 
 12. Administration. The Committee shall have the authority to
interpret and construe the terms of this Agreement in a manner consistent with the terms of the Executive Employment Agreement. Notwithstanding the foregoing, all determinations with regard to matters covered by the Executive Employment Agreement
shall be resolved in accordance with the dispute resolution provisions provided therein and such resolutions shall be binding with regard to such matters for purposes of this Agreement. 
 13. Amendment of Agreement. This Agreement may only be modified or amended in a writing signed by both parties. 

  
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 14. Waiver. Either
party’s failure to enforce any provision or provisions of this Agreement shall not in any way be construed as a waiver of any such provision or provisions, nor prevent that party thereafter from enforcing each and every other provision of this
Agreement. The rights granted both parties herein are cumulative and shall not constitute a waiver of either party’s right to assert all other legal remedies available to it under the circumstances. 

15. Further Assurances. The Grantee agrees upon request to execute any further documents or instruments necessary or desirable to carry out
the purposes or intent of this Agreement. 
 16. No Employment or Other Rights. The grant of Units hereunder shall not confer upon
the Grantee any right to be retained by, or to continue in, the employ of the Employer. 
 17. Compliance with Law. The Committee
may from time to time impose any conditions on the Units or the Company Stock underlying the Units as it deems necessary or advisable to ensure that this Grant satisfies the conditions of Rule 16b-3, and that Units are issued and the underlying
Company Stock are resold in compliance with the Securities Act. 
 18. Applicable Law. The validity, construction, interpretation
and effect of this Agreement shall be governed by, and construed and enforced in accordance with, the laws of the State of North Carolina, without giving effect to the conflicts of laws provisions thereof. 

19. Notice. Any notice to the Company provided for in this Agreement shall be addressed to the Company in care of the Compensation
Committee at 4222 Emperor Boulevard, Suite 200, Durham, North Carolina, 27703-8466, and any notice to the Grantee shall be addressed to such Grantee at the current address shown on the payroll of the Employer, or to such other address as a
party may designate to the other party in writing. Any notice shall be delivered by hand, sent by telecopy or enclosed in a properly sealed envelope addressed as stated above, deposited, postage prepaid, in a post office regularly maintained by the
United States Postal Service. 
 20. Headings. Paragraph headings are for reference only. In the event of a conflict between a
title and the content of a Paragraph, the content of the Paragraph shall control. 
 21. Counterparts. This Agreement may be
executed, including execution by facsimile signature, in one or more counterparts, each of which shall be deemed an original, and all of which together shall be deemed to be one and the same instrument. 

[Signature page to follow] 

  
 - 4 -

  
 IN WITNESS
WHEREOF, the Company has caused its duly authorized officer to execute this Agreement, and the Grantee has executed this Agreement, effective as of the Date of Grant. 

 

			
	INSPIRE PHARMACEUTICALS, INC.:
		
	By:	 	 /s/ Joseph M. Spagnardi

		
	Name:	 	 Joseph M. Spagnardi

		
	Title:	 	 SVP, General Counsel & Secretary

I hereby accept the Units described in this Agreement, and I agree to be bound by the terms of this Agreement. 

 

			
	GRANTEE:
		
	By:	 	 /s/ Charles A. Johnson

		
	Grantee:	 	 Charles A. Johnson

  
 - 5 -

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