Document:

<PAGE>
                                                                    EXHIBIT 10.1

                               SECOND AMENDMENT TO
                           FOURTH AMENDED AND RESTATED
                             MASTER RIGHTS AGREEMENT

            This Second Amendment ("Amendment") to the Fourth Amended and
Restated Master Rights Agreement ("Master Agreement") dated as of December 19,
2003 among Inhibitex, Inc., a Delaware corporation (the "Company"), and the
investors signatory thereto, is made and effective as of this 27th day of May
2004.

                              W I T N E S S E T H:

      WHEREAS, the Master Agreement provides the investors signatory thereto
with certain rights with respect to the Company;

      WHEREAS, the parties now wish to amend the Master Agreement;

      NOW, THEREFORE, in consideration of the mutual covenants contained herein,
the parties hereby agree as follows:

      1. Terms used herein and not otherwise defined herein shall have the
meanings ascribed to them in the Master Agreement.

      2. Section 1.1(m) of the Master Agreement is deleted and replaced in its
entirety with the following:

      "Initial Public Offering" means a consummated firmly underwritten public
      offering of the Company's Common Stock on a Form S-1 Registration
      Statement, or any similar form of registration statement, adopted by the
      Commission from and after the date hereof, filed with the Commission under
      the Securities Act (as defined below) with respect to which the price to
      the public in such offering is approved by the pricing committee of the
      Company's Board of Directors and is not less than $7.00 per share, which
      pricing committee consists of representatives of each of the Series C
      Stock, Series D Stock and Series E Stock."

      3. Except as amended hereby, the Master Agreement remains unchanged.

This Amendment was approved by resolution of the Board of Directors of the
Company at a meeting duly held May 26, 2004 and the consent by class vote of at
least 66 2/3%

<PAGE>
of the outstanding (i) Series B, (ii) Series C and (iii) Series D and Series E,
dated as of May 26, 2004.<PAGE>
                                                                    EXHIBIT 10.1

                       FIRST AMENDMENT TO CREDIT AGREEMENT

         THIS FIRST AMENDMENT TO CREDIT AGREEMENT dated as of December 31, 2003
(the "Agreement") is entered into among Ardent Health Services, Inc., a Delaware
corporation (the "Borrower"), each of the parties identified as "Guarantors" on
the signature pages hereto (the "Guarantors"), the Lenders party hereto and Bank
One, NA, as Administrative Agent (in such capacity, the "Administrative Agent").
All capitalized terms used herein and not otherwise defined herein shall have
the meanings given to such terms in the Credit Agreement (as defined below).

                                    RECITALS

         WHEREAS, the Borrower, the Guarantors, the Lenders and the
Administrative Agent entered into that certain Credit Agreement dated as of
August 19, 2003 (as amended and modified from time to time, the "Credit
Agreement");

         WHEREAS, the Borrower has requested and the Lenders have agreed to
amend certain terms of the Credit Agreement as set forth below;

         NOW, THEREFORE, in consideration of the premises and the mutual
covenants contained herein, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereto
agree as follows:

         1. Reaffirmation. The Loan Parties acknowledge and confirm (a) that the
Borrower's obligation to reimburse the L/C Issuer for any drawing on a Letter of
Credit is unconditional and not subject to any offsets, defenses or
counterclaims, (b) that to the best of their knowledge, the Administrative
Agent, the Collateral Agent and the Lenders have performed fully all of their
respective obligations under the Credit Agreement and the other Loan Documents
to date, and (c) by entering into this Agreement, the Lenders do not waive or
release any term or condition of the Credit Agreement or any of the other Loan
Documents or any of their rights or remedies under such Loan Documents or
applicable law or any of the obligations of any Loan Party thereunder.

         2. Amendments to the Credit Agreement. Effective on December 31, 2003,
the Credit Agreement is hereby amended as follows:

                  (a) The words "the Borrower" in the definition of
         "Intercompany Note" in Section 1.01 of the Credit Agreement are hereby
         deleted and replaced with the words "any Loan Party".

                  (b) The words "the Borrower" in the definition of
         "Intercompany Security Documents" in Section 1.01 of the Credit
         Agreement are hereby deleted and replaced with the words "any Loan
         Party".

                  (c) The definition of "Disposition" in Section 1.01 of the
         Credit Agreement is hereby amended by adding an additional subclause
         (ix) thereto in the appropriate numerical place to read as follows:
         "(ix) the disposition of disposable inventory in bulk to a third party
         which disposable inventory shall then be consigned from such third
         party to the Borrower or any Subsidiary for the benefit of or use by
         such Persons in the ordinary course of such Person's patient care
         operations,"

                  (d) The following new definitions are hereby added to Section
         1.01 of the Credit Agreement in the appropriate alphabetical order:

<PAGE>

                           "Lovelace Intercompany Loan" has the meaning set
                  forth in Section 8.02(g)(i).

                           "Quoted Rate" means, with respect to any Quoted Rate
                  Swingline Loan, the fixed or floating percentage rate per
                  annum, if any, offered by the Swing Line Lender and accepted
                  by the Borrower in accordance with the provisions hereof;
                  provided that from the date that any Lender funds a
                  participation interest in such Quoted Rate Swingline Loan, the
                  Quoted Rate for such Quoted Rate Swingline Loan shall be a
                  rate equal to the Base Rate plus the Applicable Margin.

                           "Quoted Rate Swing Line Loan" means any Swing Line
                  Loan that bears interest at the Quoted Rate.

                  (e) The penultimate sentence in Section 2.04(a) of the Credit
         Agreement is hereby amended to read as follows:

                  Each Swing Line Loan shall be a Base Rate Loan or a Quoted
                  Rate Swing Line Loan, as the Borrower may elect.

                  (f) The second sentence in Section 2.04(b) of the Credit
         Agreement is hereby amended to read as follows:

                  Each such notice must be received by the Swing Line Lender and
                  the Administrative Agent not later than 1:00 p.m. on the
                  requested borrowing date, and shall specify (i) the amount to
                  be borrowed, which shall be a minimum of $100,000, (ii) the
                  requested borrowing date, which shall be a Business Day and
                  (iii) whether such Swing Line Loan shall be a Base Rate Loan
                  or Quoted Rate Swing Line Loan.

                  (g) Subclause (iii) in Section 2.08(a) of the Credit Agreement
         is hereby amended to read as follows:

                  (iii)(A) each Swing Line Loan that is a Base Rate Loan shall
                  bear interest on the outstanding principal amount thereof from
                  the applicable borrowing date at a rate per annum equal to the
                  Base Rate plus the Applicable Rate, and (B) each Swing Line
                  Loan that is a Quoted Rate Swing Line Loan shall bear interest
                  on the outstanding principal amount thereof from the
                  applicable borrowing date at a rate per annum equal to the
                  Quoted Rate applicable thereto.

                  (h) Section 7.01(a)(i) of the Credit Agreement is hereby
         amended to read as follows:

                           (i) as soon as available, but in any event within
                  ninety days after the end of each fiscal year of the Parent, a
                  consolidated balance sheet of the Parent and its Subsidiaries
                  as at the end of such fiscal year, and the related
                  consolidated statements of income or operations, shareholders'
                  equity and cash flows for such fiscal year, setting forth in
                  each case in comparative form the figures for the previous
                  fiscal year, all in reasonable detail and prepared in
                  accordance with GAAP and SEC requirements, audited and
                  accompanied by a report and opinion of an independent
                  certified public accountant of nationally recognized standing
                  reasonably acceptable to the Required Lenders, which report
                  and opinion shall be prepared in accordance with generally
                  accepted auditing standards and shall not be subject to any
                  "going concern" or like qualification or exception or any
                  qualification or exception as to the scope of such audit; and

                                       2
<PAGE>

                  (i) Section 7.01(b)(i) of the Credit Agreement is hereby
         amended to read as follows:

                           (i) as soon as available, but in any event within
                  forty-five days after the end of each of the first three
                  fiscal quarters of each fiscal year of the Parent, a
                  consolidated balance sheet of the Parent and its Subsidiaries
                  as at the end of such fiscal quarter, and the related
                  consolidated statements of income or operations, shareholders'
                  equity and cash flows for such fiscal quarter, setting forth
                  in each case in comparative form the figures for the
                  corresponding fiscal quarter of the previous fiscal year and
                  the corresponding portion of the previous fiscal year, all in
                  reasonable detail and certified by a Responsible Officer of
                  the Parent as fairly presenting in all material respects the
                  financial condition, results of operations, shareholders'
                  equity and cash flows of the Parent and its Subsidiaries in
                  accordance with GAAP and SEC requirements, subject only to
                  normal year-end audit adjustments and the absence of
                  footnotes.

                  (j) Section 7.02(c) of the Credit Agreement is hereby amended
         to read as follows:

                           (c) within 30 days after the end of each calendar
                  month, a certificate as of the end of the immediately
                  preceding month, substantially in the form of Exhibit K and
                  certified by a Responsible Officer of the Borrower to be true
                  and correct as of the date thereof (a "Borrowing Base
                  Certificate");

                  (k) Section 7.02(d) of the Credit Agreement is hereby amended
         to read as follows:

                           (d) within 30 days after the end of each fiscal year
                  of the Parent, beginning with the fiscal year ending December
                  31, 2003, an annual business plan and budget of the Parent and
                  its Subsidiaries containing, among other things, pro forma
                  financial statements for each quarter of the next fiscal year
                  and projected Consolidated Capital Expenditures (in reasonable
                  detail) for such fiscal year.

                  (l) The penultimate sentence in the last paragraph of Section
         7.02 of the Credit Agreement is hereby amended to read as follows:

                  Notwithstanding anything contained herein, the Loan Parties
                  shall be required to deliver the Compliance Certificates
                  required by Section 7.02(b) either (a) directly to the
                  Administrative Agent and each of the Lenders in the form of
                  paper copies or (b) to the Administrative Agent and the
                  Lenders via the IntraLinks/IntraAgency website or another
                  relevant website, if any, to which each Lender and the
                  Administrative Agent have access (whether a commercial, third
                  party website or whether sponsored by the Administrative
                  Agent).

                  (m) Subclause (i) in Section 8.02(g) of the Credit Agreement
         is hereby amended to read as follows:

                           (i) $70,000,000 intercompany loan from any Loan Party
                  to Lovelace (the "Lovelace Intercompany Loan") (it being
                  understood and agreed that the consideration giving rise to
                  the Lovelace Intercompany Loan shall not be cash consideration
                  but rather the value contributed to Lovelace pursuant to the
                  Lovelace/Sandia Merger); provided that (A) Lovelace shall have
                  delivered an Intercompany Note in the amount of $70 million to
                  such Loan Party and pledged its assets to such Loan Party to
                  secure such Intercompany Note pursuant to the Intercompany
                  Security Documents and (B) such Loan Party shall have
                  delivered such Intercompany Note to the Collateral Agent,
                  executed Collateral Assignment

                                       3
<PAGE>

                  Documents and delivered such other documentation to the
                  Collateral Agent in accordance with Section 7.14.

                  (n) The last sentence of Section 8.05 of the Credit Agreement
         is hereby amended to read as follows:

                  Notwithstanding the foregoing, the parties hereto agree that
                  AHS Summit Hospital, LLC may donate the Baton Rouge Property
                  to Health Care Services Foundation.

                  (o) Section 8.11(e) of the Credit Agreement is hereby amended
         to increase the amount of permitted Consolidated Capital Expenditures
         for the period from July 1, 2003 through December 31, 2003 from
         $35,000,000 to $47,000,000.

                  (p) Section 8.12(d) of the Credit Agreement is hereby amended
         to read as follows:

                           (d) Accept or permit to be made any principal payment
                  on (i) the Lovelace Intercompany Loan or (ii) any other
                  intercompany loan made to an HMO Subsidiary in accordance with
                  the terms of Section 7.12(a)(iii) and Section 8.02(g)(ii).

         3. Conditions Precedent. This Agreement shall be effective upon the
receipt by the Administrative Agent of counterparts of this Agreement, duly
executed by the Borrower, the Guarantors and the Required Lenders.

         4. Miscellaneous.

                  (a) The Credit Agreement, and the obligations of the Loan
         Parties thereunder and under the other Loan Documents, are hereby
         ratified and confirmed and shall remain in full force and effect
         according to their terms.

                  (b) Each Guarantor (a) acknowledges and consents to all of the
         terms and conditions of this Agreement, (b) affirms all of its
         obligations under the Loan Documents and (c) agrees that this Agreement
         and all documents executed in connection herewith do not operate to
         reduce or discharge its obligations under the Credit Agreement or the
         other Loan Documents.

                  (c) The Borrower and the Guarantors hereby represent and
         warrant as follows:

                           (i) Each Loan Party has taken all necessary action to
                  authorize the execution, delivery and performance of this
                  Agreement.

                           (ii) This Agreement has been duly executed and
                  delivered by the Loan Parties and constitutes each of the Loan
                  Parties' legal, valid and binding obligations, enforceable in
                  accordance with its terms, except as such enforceability may
                  be subject to (i) bankruptcy, insolvency, reorganization,
                  fraudulent conveyance or transfer, moratorium or similar laws
                  affecting creditors' rights generally and (ii) general
                  principles of equity (regardless of whether such
                  enforceability is considered in a proceeding at law or in
                  equity).

                           (iii) No consent, approval, authorization or order
                  of, or filing, registration or qualification with, any court
                  or governmental authority or third party is required in
                  connection with the execution, delivery or performance by any
                  Loan Party of this Agreement.

                                       4
<PAGE>

                  (d) The Loan Parties represent and warrant to the Lenders that
         (i) the representations and warranties of the Loan Parties set forth in
         Article VI of the Credit Agreement and in each other Loan Document are
         true and correct as of the date hereof with the same effect as if made
         on and as of the date hereof, except to the extent such representations
         and warranties expressly relate solely to an earlier date and (ii) no
         event has occurred and is continuing which constitutes a Default or an
         Event of Default.

                  (e) This Agreement may be executed in any number of
         counterparts, each of which when so executed and delivered shall be an
         original, but all of which shall constitute one and the same
         instrument. Delivery of an executed counterpart of this Agreement by
         telecopy shall be effective as an original and shall constitute a
         representation that an executed original shall be delivered.

                  (f) THIS AGREEMENT AND THE RIGHTS AND OBLIGATIONS OF THE
         PARTIES HEREUNDER SHALL BE GOVERNED BY AND CONSTRUED AND INTERPRETED IN
         ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

                  [remainder of page intentionally left blank]

                                       5
<PAGE>

         Each of the parties hereto has caused a counterpart of this Agreement
to be duly executed and delivered as of the date first above written.

BORROWER:                  ARDENT HEALTH SERVICES, INC.,
                           a Delaware corporation

                           By: /s/ R. Dirk Allison
                              -----------------------------------------
                           Name:  R. Dirk Allison
                           Title: Executive Vice President and Chief
                                  Financial Officer

GUARANTORS:                ARDENT HEALTH SERVICES LLC,
                           a Delaware limited liability company

                           By: /s/ R. Dirk Allison
                              -----------------------------------------
                           Name:  R. Dirk Allison
                           Title: Executive Vice President and Chief
                                  Financial Officer

                           AHS ALBUQUERQUE HOLDINGS, LLC,
                           a New Mexico limited liability company
                           AHS CUMBERLAND HOSPITAL, LLC,
                           a Virginia limited liability company
                           AHS KENTUCKY HOLDINGS, INC.,
                           a Delaware corporation
                           AHS KENTUCKY HOSPITALS, INC.,
                           a Delaware corporation
                           AHS LOUISIANA HOLDINGS, INC.,
                           a Delaware corporation
                           AHS LOUISIANA HOSPITALS, INC.,
                           a Delaware corporation
                           AHS MANAGEMENT COMPANY, INC.,
                           a Tennessee corporation
                           AHS NEW MEXICO HOLDINGS, INC.,
                           a New Mexico corporation
                           AHS SAMARITAN HOSPITAL, LLC,
                           a Kentucky limited liability company
                           AHS S.E.D. MEDICAL LABORATORIES, INC.,
                           a New Mexico corporation
                           AHS SUMMIT HOSPITAL, LLC,
                           a Delaware limited liability company
                           ARDENT MEDICAL SERVICES, INC.,
                           a Delaware corporation
                           BEHAVIORAL HEALTHCARE CORPORATION,
                           a Delaware corporation

                           By: /s/ R. Dirk Allison
                              -----------------------------------------
                           Name:  R. Dirk Allison
                           Title: Senior Vice President of each of the
                                  foregoing Guarantors

<PAGE>

                           BHC MANAGEMENT SERVICES OF NEW MEXICO, LLC,
                           a Delaware limited liability company
                           BHC MANAGEMENT SERVICES OF STREAMWOOD, LLC,
                           a Delaware limited liability company
                           BHC MEADOWS PARTNER, INC.,
                           a Delaware corporation
                           BHC MONTEVISTA HOSPITAL, INC.,
                           a Nevada corporation
                           BHC OF INDIANA, GENERAL PARTNERSHIP,
                           a Tennessee general partnership
                           BHC ALHAMBRA HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC BELMONT PINES HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC CEDAR VISTA HOSPITAL, INC.,
                           a California corporation
                           BHC COLUMBUS HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC FAIRFAX HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC FOX RUN HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC FREMONT HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC GULF COAST MANAGEMENT GROUP, INC.,
                           a Tennessee corporation
                           BHC HEALTH SERVICES OF NEVADA, INC.,
                           a Nevada corporation
                           BHC HERITAGE OAKS HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC HOSPITAL HOLDINGS, INC.,
                           a Delaware corporation
                           BHC INTERMOUNTAIN HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC LEBANON HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC MANAGEMENT HOLDINGS, INC.,
                           a Delaware corporation
                           BHC MANAGEMENT SERVICES, LLC,
                           a Delaware limited liability company
                           BHC MANAGEMENT SERVICES OF INDIANA, LLC,
                           a Delaware limited liability company
                           BHC MANAGEMENT SERVICES OF KENTUCKY, LLC,
                           a Delaware limited liability company

                           By: /s/ R. Dirk Allison
                              -----------------------------------------
                           Name:  R. Dirk Allison
                           Title: Senior Vice President of each of the
                                  foregoing Guarantors

<PAGE>

                           BHC OF NORTHERN INDIANA, INC.,
                           a Tennessee corporation
                           BHC PHYSICIAN SERVICES OF KENTUCKY, LLC,
                           a Delaware limited liability company
                           BHC PINNACLE POINTE HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC PROPERTIES, INC.,
                           a Tennessee corporation
                           BHC SIERRA VISTA HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC SPIRIT OF ST. LOUIS HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC STREAMWOOD HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC VALLE VISTA HOSPITAL, INC.,
                           a Tennessee corporation
                           BHC WINDSOR HOSPITAL, INC.,
                           an Ohio corporation
                           BLOOMINGTON MEADOWS, G.P.,
                           a Delaware general partnership
                           COLUMBUS HOSPITAL, LLC,
                           a Delaware limited liability company
                           INDIANA PSYCHIATRIC INSTITUTES, INC.,
                           a Delaware corporation
                           LEBANON HOSPITAL, LLC,
                           a Delaware limited liability company
                           MESILLA VALLEY GENERAL PARTNERSHIP,
                           a New Mexico general partnership
                           MESILLA VALLEY MENTAL HEALTH ASSOCIATES, INC.,
                           a New Mexico corporation
                           NORTHERN INDIANA HOSPITAL, LLC,
                           a Delaware limited liability company
                           VALLE VISTA, LLC,
                           a Delaware limited liability company
                           WILLOW SPRINGS, LLC,
                           a Delaware limited liability company
                           AHS RESEARCH AND REVIEW, LLC,
                           a New Mexico limited liability company
                           BHC NORTHWEST PSYCHIATRIC HOSPITAL, LLC,
                           a Delaware limited liability company

                           By: /s/ R. Dirk Allison
                              -----------------------------------------
                           Name:  R. Dirk Allison
                           Title: Senior Vice President of each of the
                                  foregoing Guarantors

<PAGE>

ADMINISTRATIVE
AGENT:                           BANK ONE, NA,
                                 as Administrative Agent

                                 By: /s/ Timothy K. Boyle
                                    -----------------------------------------
                                 Name: Timothy K. Boyle
                                 Title: First Vice President

LENDERS:                         BANK ONE, NA,

                                 By: /s/ Timothy K. Boyle
                                    -----------------------------------------
                                 Name: Timothy K. Boyle
                                 Title: First Vice President

                                 BANK OF AMERICA, N.A.

                                 By: /s/ Peter D. Griffith
                                    -----------------------------------------
                                 Name: Peter D. Griffith
                                 Title: Managing Director

                                 MERRILL LYNCH CAPITAL, A DIVISION OF
                                 MERRILL LYNCH BUSINESS FINANCIAL SERVICES INC.

                                 By: /s/ Luis A. Viera
                                    -----------------------------------------
                                 Name: Luis A. Viera
                                 Title: Vice President

                                 GENERAL ELECTRIC CAPITAL CORPORATION

                                 By:
                                    -----------------------------------------
                                 Name:
                                 Title:

                                 RESIDENTIAL FUNDING CORPORATION

                                 By: /s/ Kevin Howell
                                    -----------------------------------------
                                 Name: Kevin Howell
                                 Title: SVP

                                 FLEET NATIONAL BANK

                                 By: /s/ Thomas F. Farley, Jr.
                                    -----------------------------------------
                                 Name: Thomas F. Farley, Jr.
                                 Title: Managing Director

                                 FIFTH THIRD BANK

                                 By: /s/ Sandy Hamrick
                                    -----------------------------------------
                                 Name: Sandy Hamrick
                                 Title: Managing Director

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00070-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00070-of-00352.parquet"}]]