Document:

EX-4.3

 Exhibit 4.3 

CERTIFICATE OF DESIGNATION, PREFERENCES AND RIGHTS 

OF 
 5.875% SERIES I
NON-CUMULATIVE REDEEMABLE PREFERRED 
 SHARES 

OF 
 PARTNERRE LTD.

 The 5.875% Series I Non-Cumulative Redeemable Preferred Shares shall have the designation, preferences and rights, and shall be
subject to the restrictions, as hereinafter appearing: 
 Section 1. Designation and Amount. There shall be a series of
Preferred Shares of the Company which shall be designated as “5.875% Series I Non-Cumulative Redeemable Preferred Shares,” par value $1.00 per share (hereinafter called “Series I Preferred Shares”), and the number of
shares constituting such series shall be 10,000,000. Such number of shares may be increased or decreased at any time and from time to time by resolution of the Company’s Board of Directors; provided, however, that no decrease
shall reduce the number of shares of Series I Preferred Shares to a number less than that of the shares then outstanding plus the number of shares of Series I Preferred Shares issuable upon exercise of outstanding rights, options or warrants or upon
conversion of outstanding securities issued by the Company. 
 Section 2. Definitions. For purposes of the Series I
Preferred Shares, the following terms shall have the meanings indicated: 
 “Additional Directors” shall have the meaning
set forth in Section 9(b) hereof. 
 “BMA” shall mean the Bermuda Monetary Authority (or any successor agency or
then-applicable regulatory authority). 
 “Board” shall mean the Board of Directors of the Company or any committee
authorized by such Board of Directors to perform any of its responsibilities with respect to the Series I Preferred Shares. 

“Business Day” shall mean any day other than a Saturday, Sunday or a day on which banking institutions in Hamilton, Bermuda,
or New York, New York are not required to be open. 
 “Bye-Laws” shall mean the Amended and Restated Bye-Laws of the
Company in effect as of March 18, 2016. 
 “Call Date” shall mean any date which the Company establishes for the
redemption of Series I Preferred Shares, which date must be specified in the notice mailed to holders of the Series I Preferred Shares pursuant to Section 5(d) hereof. 

“Capital Adequacy Regulations” shall mean the solvency margin, capital adequacy regulations or any other regulatory capital
rules applicable to the Company from time to time on an individual or group basis pursuant to Bermuda law and/or the laws of any other relevant jurisdiction and which set out the requirements to be satisfied by financial instruments to qualify as
solvency margin or additional solvency margin or regulatory capital (or any equivalent terminology employed by the then applicable capital adequacy regulations). 

“Capital Disqualification Event” means the Series I Preferred Shares cease to qualify, in whole or in part (including as a
result of any transitional or grandfathering provisions), for purposes of determining the Company’s (i) solvency margin, (ii) capital adequacy ratios or (iii) any other comparable ratios, regulatory capital resource or level of
the Company or any member thereof, where subdivided into tiers, as Tier 2 Capital securities under then-applicable Capital Adequacy Regulations imposed upon the Company by the BMA, which, includes the Company’s “Enhanced Capital
Requirements” (as defined in the Bermuda capital regulations), except as a result of any applicable limitation on the amount of such capital. 

“Change in Tax Law” means (i) a change in or amendment to laws, regulations or rulings of any jurisdiction, political
subdivision or taxing authority described in the next sentence, (ii) a change in the 

 
official application or interpretation of those laws, regulations or rulings, (iii) any execution of or amendment to any treaty affecting taxation to which any jurisdiction, political
subdivision or taxing authority described in the next sentence is party or (iv) a decision rendered by a court of competent jurisdiction in Bermuda or any taxing jurisdiction or any political subdivision described in the next sentence, whether
or not such decision was rendered with respect to the Company, in each case described in (i)-(iv) above occurring after April 1, 2016. The jurisdictions, political subdivisions and taxing authorities referred to in the previous sentence
are (a) Bermuda or any political subdivision or governmental authority of or in Bermuda with the power to tax, (b) any jurisdiction from or through which the Company or its dividend disbursing agent are making payments on the Series I
Preferred Shares or any political subdivision or governmental authority of or in that jurisdiction with the power to tax or (c) any other jurisdiction in which the Company or a successor is organized or generally subject to taxation or any
political subdivision or governmental authority of or in that jurisdiction with the power to tax. 
 “Common Shares” shall
mean the common shares of the Company, par value $1.00 per share. 
 “Company” shall mean PartnerRe Ltd. 

“Cumulative Shares” shall mean the Company’s Series D Cumulative Redeemable Preferred Shares, Series E Cumulative
Redeemable Preferred Shares, Series G Cumulative Redeemable Preferred Shares, Series H Cumulative Redeemable Preferred Shares and any other series of cumulative preferred shares issued by the Company from time to time. 

“Dividend Payment Date” shall mean the first day of March, June, September and December in each year, commencing on
June 1, 2016; provided, however, that if any Dividend Payment Date falls on any day other than a Business Day, the dividend payment due on such Dividend Payment Date shall be paid on the Business Day immediately after
such Dividend Payment Date. 
 “Dividend Periods” shall mean quarterly dividend periods commencing on
March 1, June 1, September 1 and December 1 of each year and ending on and including the day preceding the first day of the next succeeding Dividend Period (other than the initial Dividend Period which shall commence
March 1, 2016 and end on and including May 31, 2016 and other than the Dividend Period during which any Series I Preferred Shares shall be redeemed pursuant to Section 5 hereof, which shall end on and exclude the Call Date with
respect to the Series I Preferred Shares being redeemed). 
 “Dollars” or “$” shall mean U.S. Dollars.

 “Fully Junior Shares” shall mean the Common Shares and any other class or series of shares of the Company now or
hereafter issued and outstanding over which the Series I Preferred Shares have preference or priority in both (i) the payment of dividends and (ii) the distribution of assets on any liquidation, dissolution or winding up of the Company.

 “Issue Date” shall mean the first date on which the Series I Preferred Shares are issued and sold. 

“Junior Shares” shall mean the Common Shares and any other class or series of shares of the Company now or hereafter issued
and outstanding over which the Series I Preferred Shares have preference or priority in either (i) the payment of dividends or (ii) the distribution of assets on any liquidation, dissolution or winding up of the Company. 

“Parity Shares” shall have the meaning set forth in Section 8(b) hereof, and include, without limitation, the
Company’s Series D Cumulative Redeemable Preferred Shares, Series E Cumulative Redeemable Preferred Shares, Series F Non-Cumulative Redeemable Preferred Shares, Series G Redeemable Preferred Shares and Series H Redeemable Preferred Shares. 

“Person” shall mean any individual, firm, partnership, corporation, limited liability company or other entity, and shall
include any successor (by merger or otherwise) of such entity. 
 “Register of Members” shall mean the Register of Members
of the Company. 

  
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 “Relevant Date” means, in respect of any payment, the date on which such payment
first becomes due and payable, but if the full amount of the moneys payable has not been received by the dividend disbursing agent on or prior to such due date, it means the first date on which, the full amount of such moneys having been so received
and being available for payment to holders, notice to that effect shall have been duly given to the holders of the Series I Preferred Shares. 

“Series I Preferred Shares” shall have the meaning set forth in Section 1 hereof. 

“Set apart for payment” shall be deemed to include, without any action other than the following, the recording by the Company
in its accounting ledgers of any accounting or bookkeeping entry which indicates, pursuant to a declaration of dividends or other distribution by the Board, the allocation of funds to be so paid on any class or series of the Company’s shares;
provided, however, that if any funds for any class or series of Junior Shares or any class or series of Parity Shares are placed in a separate account of the Company or delivered to a disbursing, paying or other similar agent,
then “set apart for payment” with respect to the Series I Preferred Shares shall mean placing such funds in a separate account or delivering such funds to a disbursing, paying or other similar agent. 

“Shares” shall have the meaning set forth in Section 10(a) hereof. 

“Taxing Jurisdiction” shall have the meaning set forth in Section 11(a) hereof. 

“Transfer Agent” shall mean Computershare Trust Company, N.A., or such other agent or agents of the Company as may be
designated by the Board or its designee as the transfer agent, registrar and dividend disbursing agent for the Series I Preferred Shares. 

“Voting Preferred Shares” shall have the meaning set forth in Section 9(b) hereof. 

Section 3. Dividends. 

(a) The holders of Series I Preferred Shares shall be entitled to receive, when, as and if declared by the Board, out of funds legally
available for the payment of dividends, non-cumulative preferential cash dividends in an amount per share equal to 5.875% of the liquidation preference per annum (equivalent to $1.46875 per share), except as provided in Section 3(b) hereof.
Such dividends shall be payable quarterly, when, as and if declared by the Board, on each Dividend Payment Date, commencing on the first Dividend Payment Date after the Issue Date. Each such dividend, when, as and if declared, shall be payable to
the holders of record of Series I Preferred Shares as they appear in the Register of Members at the close of business on the tenth calendar day preceding the applicable Dividend Payment Date, whether or not a Business Day. 

(b) The amount of dividends payable for any period shorter than a full Dividend Period, on the Series I Preferred Shares shall be computed on
the basis of a 360-day year consisting of twelve 30-day months. Holders of Series I Preferred Shares shall not be entitled to any dividends, whether payable in cash, property or shares, in excess of dividends, actually declared by the Board, on the
Series I Preferred Shares other than additional amounts payable pursuant to Section 5(b) or Section 11 hereof. No interest, or sum of money in lieu of interest, shall be payable in respect of any undeclared or declared but unpaid dividends
on the Series I Preferred Shares. 
 (c) Dividends on the Series I Preferred Shares shall not be cumulative. Accordingly, if the Board does
not declare a dividend on the Series I Preferred Shares in respect of any Dividend Period before the related Dividend Payment Date, such dividend will not be payable and the Company shall have no obligation to pay a dividend for that Dividend Period
on the Dividend Payment Date or at any future time, whether or not dividends are declared for any future Dividend Period on the Series I Preferred Shares or any other preferred shares. 

(d) So long as any Series I Preferred Shares are outstanding, no dividends or other distributions, except as described in the immediately
following sentence, shall be declared or paid or set apart for payment on any class or series of Parity Shares for any period unless dividends have been or contemporaneously are declared and paid or declared and a sum sufficient for the payment
thereof set apart 

  
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for such payment on the Series I Preferred Shares for the latest completed Dividend Period, and in the case of Cumulative Shares, for all Dividend Periods terminating on or prior to the dividend
payment date in respect of the dividend or other distribution on such class or series of Cumulative Shares. When dividends on the Series I Preferred Shares are not paid in full or a sum sufficient for such payment is not set apart, as aforesaid, all
dividends declared upon Series I Preferred Shares and all dividends declared upon any class or series of Parity Shares shall be declared ratably in proportion to the respective amounts of unpaid dividends on the Series I Preferred Shares and on such
Parity Shares, whether accrued but unpaid or declared but unpaid. 
 (e) So long as any Series I Preferred Shares are outstanding,
(i) no dividends or other distributions (other than dividends or distributions paid solely in shares of, or options, warrants or rights to subscribe for or purchase shares of, Fully Junior Shares) shall be declared or paid or set apart for
payment and no other distribution shall be declared or paid or set apart for payment upon Junior Shares, nor (ii) shall any Junior Shares be redeemed, purchased or otherwise acquired (other than a redemption, purchase or other acquisition of
Common Shares made for purposes of an employee incentive or benefit plan of the Company or any subsidiary of the Company) for any consideration (or any moneys be paid to or made available for a sinking fund for the redemption of any Junior Shares)
by the Company, directly or indirectly (except by conversion into or exchange for Fully Junior Shares) ((i) and (ii) collectively, “Distributions”), unless in each case (1) the dividends on all outstanding Series I Preferred
Shares and any Parity Shares shall have been or contemporaneously are declared and paid or declared and a sum sufficient for the payment thereof set apart for payment for the latest completed Dividend Period, and, in the case of the Cumulative
Shares, for all past Dividend Periods and (2) sufficient funds shall have been or contemporaneously are set apart for the payment of the dividends for the current Dividend Period with respect to the Series I Preferred Shares and the current
dividend period with respect to such Parity Shares. Following the Issue Date and until December 31, 2020, Distributions declared or paid with respect to any fiscal quarter shall be less than, in the aggregate, 67% of the Company’s net
income (“Net Income”), as determined in accordance with United States generally accepted accounting principles, during such fiscal quarter (such amount, the “Distributable Amount”), provided, that notwithstanding the foregoing,
with respect to the first fiscal quarter immediately following March 18, 2016, the “Distributable Amount” shall be defined as the sum of (x) 67% of the Company’s Net Income during such fiscal quarter, plus
(y) (A) 67% of the Company’s Net Income during the 2015 fiscal year, minus (B) the sum of (1) the aggregate amount of ordinary course quarterly cash dividends on the Common Shares paid during the 2015 fiscal year plus
(2) the aggregate amount paid by the Company during the 2015 fiscal year to repurchase the Common Shares (the “Initial Distributable Amount”); provided, further, that if the Company does not make aggregate Distributions of all of the
Distributable Amount during any fiscal quarter, such remaining amount shall carryover and be available for Distributions in subsequent fiscal quarters, regardless of the Company’s Net Income during such subsequent fiscal quarters. 

(f) No dividends on Series I Preferred Shares shall be declared by the Board or paid or set apart for payment by the Company at such time as
the terms and provisions of any agreement of the Company, including any agreement relating to its indebtedness, prohibit such declaration, payment or setting apart for payment or provide that such declaration, payment or setting apart for payment
would constitute a breach thereof or a default thereunder, or if such declaration, payment or setting apart shall be restricted or prohibited by law. 

Section 4. Liquidation Preference. 

(a) In the event of any liquidation, dissolution or winding up of the Company, whether voluntary or involuntary, before any dividend payment or
distribution of the assets of the Company (whether capital or surplus) shall be made or set apart for payment to the holders of Junior Shares, the holders of the Series I Preferred Shares shall be entitled to receive from the Company’s assets
legally available for distribution to shareholders $25.00 per Series I Preferred Share plus an amount equal to dividends declared but unpaid thereon, if any, to the date of final distribution to such holders; but such holders of Series I Preferred
Shares shall not be entitled to any further payment. If, upon any liquidation, dissolution or winding up of the Company, the assets of the Company, or proceeds thereof, distributable among the holders of the Series I Preferred Shares shall be
insufficient to pay in full the preferential amount aforesaid and liquidating payments on any shares of any class or series of Parity Shares, then such assets, or the proceeds thereof, 

  
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shall be distributed among the holders of Series I Preferred Shares and any such Parity Shares ratably in accordance with the respective amounts that would be payable on such Series I Preferred
Shares and any such Parity Shares if all amounts payable thereon were paid in full. For the purposes of this Section 4, (i) a consolidation, amalgamation or merger of the Company with one or more corporations, limited liability companies
or other entities, (ii) a sale, lease or conveyance of all or substantially all of the shares or the property or business of the Company or (iii) a statutory share exchange, shall not be deemed to be a liquidation, dissolution or winding
up, voluntary or involuntary, of the Company. 
 (b) Subject to the rights of the holders of shares of any series or class or classes of
shares ranking on a parity with or prior to the Series I Preferred Shares upon liquidation, dissolution or winding up, upon any liquidation, dissolution or winding up of the Company, after payment shall have been made in full to the holders of the
Series I Preferred Shares, as provided in this Section 4, any other series or class or classes of Junior Shares shall, subject to the respective terms and provisions (if any) applying thereto, be entitled to receive any and all assets remaining
to be paid or distributed, according to their respective numbers of shares, and the holders of the Series I Preferred Shares shall not be entitled to share therein. 

Section 5. Redemption at the Option of the Company. 

(a) Subject to Section 5(d), Section 5(e), Section 5(f) and Section 5(g) hereof, the Series I Preferred Shares shall not be
redeemable by the Company prior to the fifth anniversary of the Issue Date. On and after the fifth anniversary of the Issue Date, the Company, at its option, may redeem the Series I Preferred Shares, in whole at any time or from time to time in
part, for cash at a redemption price of $25.00 per Series I Preferred Share, plus any amounts payable pursuant to Section 5(b) hereof. 

(b) Upon any redemption of Series I Preferred Shares pursuant to this Section 5, the Company shall pay, in addition to the redemption
price stated in Section 5(a), an amount equal to the portion of the quarterly dividend attributable to the then-current Dividend Period to, but excluding, the Call Date. If the Call Date falls after a dividend payment record date and prior to
the corresponding Dividend Payment Date, then each holder of Series I Preferred Shares at the close of business on such dividend payment record date shall be entitled to the dividend attributable to the then-current Dividend Period on such shares on
the corresponding Dividend Payment Date notwithstanding the redemption of such shares before such Dividend Payment Date. Except as provided above, the Company shall make no payment or allowance for unpaid dividends, whether or not declared, on
Series I Preferred Shares called for redemption. 
 (c) Unless dividends on the Series I Preferred Shares and any class or series of Parity
Shares shall have been declared and paid or declared and a sum sufficient for the payment thereof set apart for payment for the latest completed Dividend Period, and, in the case of the Cumulative Shares, for all past Dividend Periods, the Series I
Preferred Shares and any Parity Shares may not be redeemed under this Section 5 and the Company may not purchase or acquire Series I Preferred Shares or any Parity Shares, otherwise than pursuant to a purchase or exchange offer made on the same
terms (other than in respect of arrearages on the Cumulative Shares) to all holders of Series I Preferred Shares and Parity Shares. 
 (d)
Notice of the redemption of any Series I Preferred Shares under this Section 5 shall be mailed by first-class mail to each holder of record of Series I Preferred Shares to be redeemed at the address of each such holder as shown in the Register
of Members, not less than 30 nor more than 90 days prior to the Call Date. Neither the failure to mail any notice required by this paragraph (d), nor any defect therein or in the mailing thereof, to any particular holder, shall affect the
sufficiency of the notice or the validity of the proceedings for redemption with respect to the other holders. Any notice which was mailed in the manner herein provided shall be conclusively presumed to have been duly given on the date when the same
would be delivered in the ordinary course of transmission, whether or not the holder receives the notice. Each such mailed notice shall state, as appropriate: (1) the Call Date; (2) the number of Series I Preferred Shares to be redeemed
and, if fewer than all the Series I Preferred Shares held by such holder are to be redeemed, the number of such shares to be redeemed from such holder; (3) the redemption price (including any additional amounts payable pursuant to
Section 5(b)); and (4) the place or places at which certificates, if any, for such Series I Preferred Shares are to be surrendered. Notice having been mailed as aforesaid, from and after the Call Date (unless the Company shall fail to make
available, as hereinafter provided, an amount of cash necessary to effect such redemption), (i) such shares shall no longer be deemed to be outstanding; (ii) all 

  
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rights of the holders thereof as holders of Series I Preferred Shares of the Company shall cease (except the right to receive cash payable upon such redemption, without interest thereon, upon
surrender and endorsement of their certificates, if any, if so required and to receive any additional amounts payable thereon); and (iii) any officer of the Company shall be entitled, on behalf of such holder and as its attorney-in-fact, to
execute and deliver any and all documents as may be necessary to effect such redemption. The Company’s obligation to provide cash in accordance with the preceding sentence shall be deemed fulfilled if, on or before the Call Date, the Company
shall deposit with a bank or trust company (which may be an affiliate of the Company) that has an office in the Borough of Manhattan, City of New York, and that has, or is an affiliate of a bank or trust company that has, capital and surplus of at
least $50,000,000, funds necessary for such redemption, in trust, with irrevocable instructions that such cash be applied to the redemption of the Series I Preferred Shares so called for redemption. No interest shall accrue for the benefit of the
holders of Series I Preferred Shares to be redeemed on any cash so set aside by the Company. Subject to applicable escheat laws, any such cash unclaimed at the end of two years from the Call Date shall revert to the general funds of the Company,
after which reversion the holders of such shares so called for redemption shall look only to the general funds of the Company for the payment of such cash. 

As promptly as practicable after the surrender, in accordance with the notice given as aforesaid, of the certificates, if any, for any Series
I Preferred Shares so redeemed (properly endorsed or assigned for transfer, if the Company shall so require and if the notice shall so state), such shares shall be exchanged for any cash (without interest thereon) for which such shares have been
redeemed. If fewer than all the outstanding Series I Preferred Shares are to be redeemed, shares to be redeemed shall be selected by the Company from outstanding Series I Preferred Shares not previously called for redemption pro rata (as nearly as
may be practicable), by lot or by any other method determined by the Company in its sole discretion to be equitable. If fewer than all the Series I Preferred Shares represented by any certificate are redeemed, then new certificates representing the
unredeemed shares shall be issued without cost to the holder thereof. 
 (e) The Company may redeem for cash the Series I Preferred Shares
at any time in whole or from time to time in part, upon not less than 30 days nor more than 60 days prior written notice in accordance with the procedures set forth in this Section 5, at a redemption price of $25.00 per share plus an amount
equal to the portion of the quarterly dividend attributable to the then-current dividend period to, but excluding, the Call Date, within 90 days after the Company has reasonably determined that, as a result of (i) any amendment to, or change
in, the laws or regulations of Bermuda that is enacted or becomes effective after the Issue Date; (ii) any proposed amendment to, or change in, those laws or regulations that is announced or becomes effective after the Issue Date; or
(iii) any official administrative decision or judicial decision or administrative action or other official pronouncement interpreting or applying those laws or regulations that is announced after the Issue Date, a Capital Disqualification Event
has occurred; provided that any such redemption in part may only be made if (x) the Company has reasonably determined that the portion of the Series I Preferred Shares to be redeemed are the subject of the Capital
Disqualification Event and (y) after giving effect to such redemption, the Company has reasonably determined that a Capital Disqualification Event will not exist with respect to the then-outstanding Series I Preferred Shares and such redemption
will not result in the suspension or removal of the Series I Preferred Shares from New York Stock Exchange listing. 
 (f) The Company may
redeem for cash the Series I Preferred Shares at any time in whole or from time to time in part, upon not less than 30 days nor more than 60 days prior written notice in accordance with the procedures set forth in this Section 5, at a
redemption price of $25.00 per share plus an amount equal to the portion of the quarterly dividend attributable to the then-current dividend period to, but excluding, the Call Date, if as a result of a Change in Tax Law there is a substantial
probability that the Company or any successor would be required to pay any additional amounts with respect to the Series I Preferred Shares and the payment of those additional amounts cannot be avoided by the use of any reasonable measures available
to the Company or any successor corporation. 
 (g) The Company may redeem for cash any or all Series I Preferred Shares at any time in
whole or from time to time in part, upon not less than 30 days nor more than 60 days prior written notice in accordance with the procedures set forth in this Section 5, at a redemption price of $25.00 per share plus an amount equal to the
portion of the quarterly dividend attributable to the then-current dividend period to, but 

  
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excluding, the Call Date, if there is a substantial probability that the entity formed by a consolidation, merger or amalgamation involving the Company or the entity to which the Company conveys,
transfers or leases substantially all its properties and assets will be required to pay additional amounts in respect of any tax, assessment or governmental charge imposed on any holder of Series I Preferred Shares as a result of a Change in Tax Law
that occurs after the date of the consolidation, merger, amalgamation, conveyance, transfer or lease and the payment of those additional amounts cannot be avoided by the use of any reasonable measures available to the Company or any successor
corporation. 
 Section 6. Substitution or Variation. 

(a) In lieu of a redemption upon a Capital Disqualification Event as described in Section 5(e), or a redemption upon a Change in Tax Law
as described in Section 5(f), upon or following such Capital Disqualification Event or Change in Tax Law, the Company may, without the consent of any holders of the Series I Preferred Shares, vary the terms of, or exchange for new securities,
that (1) in the case of a Capital Disqualification Event, for purposes of determining the solvency margin, capital adequacy ratios or any other comparable ratios, regulatory capital resource or level of the Company or any member thereof, where
subdivided into tiers, would cause the Series I Preferred Shares to become securities that qualify as Tier 2 Capital securities under then-applicable Capital Adequacy Regulations imposed upon us by the BMA, which includes the Company’s enhanced
capital requirements (as defined in the Bermuda capital regulations) or (2) in the case of a Change in Tax Law, would eliminate the substantial probability that the Company or any successor corporation would be required to pay any additional
amounts with respect to the Series I Preferred Shares as a result of a Change in Tax Law. In either case, the terms of the varied securities or new securities considered in the aggregate may not be less favorable to holders than the terms of the
Series I Preferred Shares prior to being varied or exchanged; provided (i) that no such variation of terms or securities received in exchange will change the specified denominations, or the amount of dividends payable on, the
Call Dates (other than any extension of the period during which an optional redemption may not be exercised by the Company) or currency of, the Series I Preferred Shares, (ii) reduce the liquidation preference thereof, (iii) lower the
ranking of the securities, (iv) reduce the voting threshold for the issuance of senior stock or (v) change the foregoing list of items that may not be so amended as part of such variation or exchange. Further, no such variation of terms or
securities received in exchange may impair the right of a holder of the securities to institute suit for the payment of any amounts due (as provided herein), but unpaid with respect to such holder’s securities. 

(b) Prior to any variation or exchange, the Company will be required to (1) receive an opinion of independent legal advisers of
recognized standing to the effect that holders and beneficial owners of the Series I Preferred Shares (including as holders and beneficial owners of the varied or exchanged securities) will not recognize income, gain or loss for United States
federal income tax purposes as a result of such variation or exchange and will be subject to United States federal income tax on the same amounts, in the same manner and at the same times as would have been the case had such variation or exchange
not occurred and (2) deliver a certificate signed by two executive officers of the Company to the Transfer Agent for the Series I Preferred Shares confirming that (a) a Capital Disqualification Event or a Change in Tax Law has occurred and
is continuing (as reasonably determined by the Company) and (b) that the terms of the varied or new securities, considered in the aggregate, are not less favorable to holders than the terms of the Series I Preferred Shares prior to being varied
or exchanged (as reasonably determined by the Company). 
 (c) Any variation or exchange of the Series I Preferred Shares described in this
Section 6 will be made after notice is given to the holders of the Series I Preferred Shares not less than 30 nor more than 60 days prior to the date fixed for variation or exchange, as applicable. 

Section 7. Shares To Be Retired. All Series I Preferred Shares which shall have been issued and reacquired in any manner by
the Company shall be restored to the status of authorized but unissued shares of the Company’s shares, without designation as to class or series. 

  
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 Section 8. Ranking. Any class or series of shares of the Company shall be deemed
to rank: 
 (a) prior to the Series I Preferred Shares, as to the payment of dividends and as to distribution of assets upon liquidation,
dissolution or winding up of the Company, if the holders of such class or series shall be entitled to the receipt of dividends or of amounts distributable upon liquidation, dissolution or winding up, as the case may be, in preference or priority to
the holders of Series I Preferred Shares; 
 (b) on a parity with the Series I Preferred Shares, as to the payment of dividends and as to
distribution of assets upon liquidation, dissolution or winding up of the Company, whether cumulative or non-cumulative, and whether or not the dividend rates, dividend payment dates or redemption or liquidation prices per share thereof shall be
different from those of the Series I Preferred Shares, if the holders of such class or series and the Series I Preferred Shares shall be entitled to the receipt of dividends and of amounts distributable upon liquidation, dissolution or winding up in
proportion to their respective amounts of declared but unpaid or accrued and unpaid dividends per share or liquidation preferences, without preference or priority one over the other (“Parity Shares”); 

(c) junior to the Series I Preferred Shares, as to the payment of dividends or as to the distribution of assets upon liquidation, dissolution
or winding up of the Company, if such class or series shall be Junior Shares; and 
 (d) junior to the Series I Preferred Shares, as to the
payment of dividends and as to the distribution of assets upon liquidation, dissolution or winding up of the Company, if such class or series shall be Fully Junior Shares. 

Section 9. Voting Rights. 

(a) Except as otherwise provided in this Section 9 and as otherwise required by law, holders of the Series I Preferred Shares shall have
no voting rights. 
 (b) Whenever, at any time or times, dividends have not been declared and paid on Series I Preferred Shares or any class
or series of non-cumulative Parity Shares in an amount equivalent to dividends for six full Dividend Periods (whether or not consecutive), then, immediately upon the happening of such event, the holders of Series I Preferred Shares, together with
the holders of shares of every class or series of non-cumulative Parity Shares (all such other classes or series, the “Voting Preferred Shares”), voting as a single class regardless of class or series, shall have the right to elect
two directors to the Board of the Company (the “Additional Directors”) at any general meeting of shareholders or at a special meeting of the holders of the Series I Preferred Shares called as hereinafter provided. At any time after
such voting power shall have been so vested in the holders of Series I Preferred Shares and the Voting Preferred Shares, the Corporate Secretary of the Company may, and upon the written request of any holder of Series I Preferred Shares (addressed
to the Corporate Secretary at the principal office of the Company) shall, call a special meeting of the holders of the Series I Preferred Shares and of the Voting Preferred Shares for the election of the Additional Directors, such call to be made by
notice similar to that provided in the Bye-Laws for a special general meeting of the shareholders or as required by law. If any such special meeting required to be called as above provided shall not be called by the Corporate Secretary within 30
days after receipt of any such request, then any holder of Series I Preferred Shares may call such meeting, upon the notice above provided, and for that purpose shall have access to the Register of Members. Alternatively, the Additional Directors
may be elected by a resolution in writing, which may be in counterparts, signed by all of the holders of the Series I Preferred Shares and the Voting Preferred Shares. If at the time the voting power referred to in this Section 9(b) is vested
in the holders of the Series I Preferred Shares and the Voting Preferred Shares, there are not two vacancies on the Board of the Company, the holders of the Series I Preferred Shares and the Voting Preferred Shares shall have the right to increase
the size of the Board by two directors, to the extent permitted by Bermuda law, provided that any such increase in the size of the Board shall not delay the exercise of such voting power for a period in excess of thirty days from
the date such holders of the Series I Preferred Shares and the Voting Preferred Shares request the Corporate Secretary to call a meeting for the purpose of electing the Additional Directors. The Additional Directors shall hold office until the next
annual general meeting of the shareholders or until the office of Additional Director terminates as hereinafter provided. Any Additional Director may be removed, with or without cause, by a majority vote at any special meeting of the holders of the
Series I Preferred Shares and of the Voting Preferred Shares, voting as a single class, provided that the notice of any such meeting convened for 

  
 8 

 
the purpose of removing an Additional Director shall contain a statement of the intention so to do and be served on such Additional Director not less than 14 days before the meeting and at such
meeting such Additional Director shall be entitled to be heard on the motion for such Additional Director’s removal. In the event of any vacancy in the office of Additional Director, a successor shall be elected by the holders of the Series I
Preferred Shares and the Voting Preferred Shares, voting as a single class, at any general meeting of shareholders or at a special meeting of the holders of the Series I Preferred Shares and the Voting Preferred Shares called in accordance with the
procedures described above for the election of Additional Directors, or by a written resolution as provided above, such successor to hold office until the next annual general meeting of the shareholders or until the office of Additional Director
terminates as hereinafter provided. If an interim vacancy shall occur in the office of Additional Director prior to a general meeting of the shareholders or a special meeting or written resolution of the holders of the Series I Preferred Shares and
the Voting Preferred Shares, a successor shall be elected by the Board upon nomination by the then remaining Additional Director or the successor of such remaining Additional Director, to serve until a successor is elected in accordance with the
preceding sentence or until the office of Additional Director terminates as hereinafter provided; provided, however, that if no remaining Additional Director or successor of such Additional Director is then in office,
Additional Directors shall be elected in accordance with the procedures described in the immediately preceding sentence. Whenever dividends on the Series I Preferred Shares and the Voting Preferred Shares then outstanding have been paid in full, or
declared and sufficient funds have been set apart for payment, for at least four consecutive dividend periods, then the rights of holders of the Series I Preferred Shares and of the Voting Preferred Shares to elect Additional Directors shall cease
(but subject always to the same provision for the vesting of such rights in the case of any future non-payments in an amount equivalent to dividends for six full Dividend Periods), and the terms of office of the Additional Directors so elected by
the holders of Series I Preferred Shares and the Voting Preferred Shares to the Company’s Board shall immediately terminate and, if the size of the Board was increased for the purposes of the Additional Directors, the number of directors
constituting the Board shall be reduced accordingly. 
 (c) Any Additional Directors shall be in addition to any additional directors that
may be elected pursuant to the certificates of designation for the Cumulative Shares. Although the Series I Preferred Shares are Parity Shares with respect to the Cumulative Shares, and notwithstanding any provision of the certificate of designation
of any series of Cumulative Shares, holders of the Series I Preferred Shares will not be entitled to vote with the holders of the Cumulative Shares for the election of additional directors in circumstances where the holders of Cumulative Shares are
entitled to do so. 
 (d) So long as any Series I Preferred Shares are outstanding, in addition to any other vote or consent of shareholders
required by law or by the Bye-Laws, the affirmative vote of the holders of at least 75% of the Series I Preferred Shares at the time outstanding, acting as a single class, given in writing without a meeting or by vote in person or by proxy at a
meeting, shall be necessary for effecting or validating: 
 (i) Any amendment, alteration or repeal of any of the provisions
of the Company’s Memorandum of Association, Bye-Laws or this Certificate of Designation that would vary the rights, preferences or voting powers of the holders of the Series I Preferred Shares; 

(ii) An amalgamation, consolidation, merger or statutory share exchange that affects the Series I Preferred Shares, unless in
each such case each Series I Preferred Share (i) shall remain outstanding with no variation in its rights, preferences or voting powers or (ii) shall be converted into or exchanged for a preferred share of the surviving entity having
rights, preferences and voting powers identical to that of a Series I Preferred Share; or 
 (iii) The authorization,
creation or any increase in the authorized amount of, any shares of any class or series or any security convertible into shares of any class or series ranking prior to the Series I Preferred Shares in the payment of dividends or the distribution of
assets on any liquidation, dissolution or winding up of the Company; provided, however, that any action to authorize or create or to increase the authorized amount of, any Fully Junior Shares, Junior Shares or Parity Shares shall
not be deemed to vary the rights, preferences or voting powers of the holders of Series I Preferred Shares; and provided, further, that no such vote of the holders of Series I Preferred Shares shall be required if, prior to
the time any vote is to be taken, all outstanding Series I Preferred Shares shall have been redeemed. 

  
 9 

 (e) The holders of the Series I Preferred Shares shall not be entitled to vote on any sale of all
or substantially all of the assets of the Company. 
 (f) For purposes of any vote by the holders of the Series I Preferred Shares pursuant
to the foregoing provisions of this Section 9, each Series I Preferred Share shall have one (1) vote per share, except that when any class or series of Voting Preferred Shares shall have the right to vote with the Series I Preferred Shares
as a single class on any matter, then the Series I Preferred Shares and such class or series of Voting Preferred Shares shall have with respect to such matters one (1) vote per $25.00 of stated liquidation preference. Except as otherwise
required by applicable law or as set forth herein, the Series I Preferred Shares shall not have any other voting rights or powers, and the consent of the holders thereof shall not be required for the taking of any action by the Company. 

Section 10. Limitation on Transfer and Ownership. 

(a) Limitation. Notwithstanding any other provision of the terms of the Series I Preferred Shares, except as provided in this
Section 10, no Person shall be permitted to Own or Control (as such terms are defined in the Bye-Laws) shares in the Company (including the Series I Preferred Shares) (the “Shares”) to the extent that such holder or any other
Person would be in violation of Bye-Laws 6.1; nor may any Shares be issued or any transfer of Shares be made if the effect of such issuance or transfer would be to cause a violation of Bye-Laws 6.1. To the extent that, for any reason whatsoever and
by any method howsoever, a Person, whether an existing shareholder or not of the Company, would otherwise be considered a Ten Percent Shareholder (as such term is defined in the Bye-Laws), then Bye-Laws 6.2 to 6.6 (and any other applicable Bye-Laws)
shall apply. No transfer (including a repurchase by the Company) may be made if the effect of such transfer would result in the transferee or any other shareholder of the Company controlling in excess of nine and nine-tenths per cent (9.9%) of
all of the issued and outstanding Shares. Nothing in this Section 10(a) shall preclude the settlement of any transaction entered into through the facilities of the New York Stock Exchange. 

(b) Exemptions. The limitation on ownership set forth in Section 10(a) shall not apply to the acquisition of Series I
Preferred Shares by an underwriter as part of the public offering of Series I Preferred Shares. The Board may waive the restrictions on transfer set forth in Section 10(a) in its discretion and on a case by case basis. The Board will not be
liable to the Company, its shareholders or any other Person whatsoever for any errors in judgment made by it in granting any waiver or waivers to the foregoing restrictions in any case so long as it has acted in good faith. 

Section 11. Payment of Additional Amounts. 

(a) The Company will make all payments on the Series I Preferred Shares free and clear of and without withholding or deduction at source for,
or on account of, any present or future taxes, fees, duties, assessments or governmental charges of whatever nature imposed or levied by or on behalf of Bermuda or any other jurisdiction in which the Company is organized or any political subdivision
or taxing authority thereof or therein (a “Taxing Jurisdiction”), unless such taxes, fees, duties, assessments or governmental charges are required to be withheld or deducted by (x) the laws (or any regulations or rulings
promulgated thereunder) of a Taxing Jurisdiction or (y) an official position regarding the application, administration, interpretation or enforcement of any such laws, regulations or rulings (including, without limitation, a holding by a court
of competent jurisdiction or by a taxing authority in a Taxing Jurisdiction). If a withholding or deduction at source is required by either (x) or (y), the Company will, subject to certain limitations and exceptions described in clauses
(b) and (c) of this Section 11, pay to the holders of the Series I Preferred Shares such additional amounts as dividends as may be necessary so that the net amounts paid will be equal to the amounts the Company would otherwise have
been required to pay had no such withholding or deduction been required. 
 (b) The Company will not be required to pay any additional
amounts for or on account of: 
 (i) any tax, fee, duty, assessment or governmental charge of whatever nature that would not
have been imposed but for the fact that such holder was a resident, domiciliary or national of, or engaged in business or maintained a permanent establishment or was physically present in, the relevant taxing jurisdiction or any political
subdivision thereof or otherwise had some connection with the relevant taxing jurisdiction other than by reason of the mere ownership of, or receipt of payment under, such Series I Preferred Shares; 

  
 10 

 (ii) any Series I Preferred Shares presented for payment more than 30 days after
the Relevant Date; 
 (iii) any estate, inheritance, gift, sale, transfer, personal property or similar tax, assessment or
other governmental charge or any tax, assessment or other governmental charge that is payable otherwise than by withholding or deduction from payment of the liquidation preference; 

(iv) any tax, fee, duty, assessment or other governmental charge that is imposed or withheld by reason of the failure by the
holder of such Series I Preferred Shares to comply with any reasonable request by us addressed to the holder within 90 days of such request (a) to provide information concerning the nationality, residence or identity of the holder or
(b) to make any declaration or other similar claim or satisfy any information or reporting requirement, which is required or imposed by statute, treaty, regulation or administrative practice of the relevant taxing jurisdiction or any political
subdivision thereof as a precondition to exemption from all or part of such tax, fee, duty, assessment or other governmental charge; 

(v) any withholding or deduction required to be made pursuant to any EU Directive on the taxation of savings implementing the
conclusions of the ECOFIN Council meetings of 26-27 November 2000, 3 June 2003 or any law implementing or complying with, or introduced in order to conform to, such EU Directive; or 

(vi) any combination of items (i), (ii), (iii), (iv) or (v). 

(c) The Company will not pay additional amounts with respect to any payment on any Series I Preferred Shares to any holder who is a fiduciary,
partnership, limited liability company or other pass-through entity other than the sole beneficial owner of such Series I Preferred Shares if such payment would be required by the laws of the relevant taxing jurisdiction (or any political
subdivision or relevant taxing authority thereof or therein) to be included in the income for tax purposes of a beneficiary or partner or settlor with respect to such fiduciary or a member of such partnership, limited liability company or other
pass-through entity or a beneficial owner to the extent such beneficiary, partner or settlor would not have been entitled to such additional amounts had it been the holder of the Series I Preferred Shares. 

(d) If there is a substantial probability that the Company or any successor corporation would become obligated to pay any additional amounts
as a result of a Change in Tax Law, the Company will also have the option to redeem the Series Preferred Shares as set forth in Section 5(f) hereof. 

Section 12. Record Holders. The Company and the Transfer Agent may deem and treat the record holder of any Series I Preferred
Shares, as the same appears in the Register of Members, as the true and lawful owner thereof for all purposes, and neither the Company nor the Transfer Agent shall be affected by any notice to the contrary. Payments in respect of Series I Preferred
Shares shall be sent to the holders thereof at their address most recently noted on the Register of Members and, in the case of joint holders of Series I Preferred Shares, may be made to all such joint holders but sent to that one of the joint
holders of Series I Preferred Shares who is first named in the Register of Members at his or her address most recently noted in the Register of Members or shall be made payable to such person or persons and sent to such address as all the joint
holders of such Series I Preferred Shares may in writing direct. Cheques in payment of any obligation of the Company to holders of Series I Preferred Shares shall be sent by first-class mail at the risk of the holder of the Series I Preferred
Shares, and due payment of a cheque shall be full satisfaction of the obligation represented thereby notwithstanding any notice which the Company may have whether express or otherwise of any right, title or interest or claim of any other person to
or in such Series I Preferred Shares. 
 Section 13. Sinking Fund. The Series I Preferred Shares shall not be entitled to
the benefits of any retirement or sinking fund. 
 Section 14. Conversion. The Series I Preferred Shares shall not be
convertible into or exchangeable for any other securities of the Company. 

  
 11 

 Section 15. Jurisdiction; Governing Law. The Company expressly accepts and
irrevocably submits to the non-exclusive jurisdiction of the United States Federal or New York State court sitting in the Borough of Manhattan, The City of New York, New York, over any suit, action or proceeding arising out of or relating to the
Series I Preferred Shares. To the fullest extent it may effectively do so under applicable law, the Company irrevocably waives and agrees not to assert, by way of motion, as a defense or otherwise, any claim that it is not subject to the
jurisdiction of any such court, any objection that it may now or hereafter have to the laying of the venue of any such suit, action or proceeding brought in any such court and any claim that any such suit, action or proceeding brought in any such
court has been brought in an inconvenient forum. The Company agrees, to the fullest extent that it may effectively do so under applicable law, that a judgment in any suit, action or proceeding of such nature brought in any such court shall be
conclusive and binding upon the Company, subject to rights of appeal and may be enforced in the courts of the United States of America or the State of New York (or any other court the jurisdiction to which the Company is or may be subject) by a suit
upon such judgment. Bermuda substantive law will be applied in any such proceeding. 

  
 12EX-10.1

 Exhibit 10.1 

Sage Therapeutics 

 

2016 Annual Bonus Incentive Plan 

Objectives 
  

	 	•	 	To provide incentive to employees to focus on and contribute to achieving and exceeding our corporate goals consistent with our Pay-for-Performance philosophy and culture. 

 

	 	•	 	To recognize employees for achieving and exceeding individual goals that contribute to the success of Sage. 

  

	 	•	 	To attract and retain talent in a competitive marketplace. 

  

	 	•	 	To ensure that our total compensation is competitive with the external marketplace when we achieve and exceed our corporate goals. 

 Plan Design: how it works for you 

Eligibility 
  

	 	•	 	All regular full-time Sage employees. Eligibility for the Plan will be determined on a case-by-case basis for regular employees who work less than full time. 

Target Bonus 
  

	 	•	 	The size of your target bonus is based on your position and is expressed as a percentage of your base salary. You will be informed of your target bonus percent at hire and upon any position change or change to
overall bonus targets. 

 Adjusting Your Actual Target Bonus Based on Company Performance 

 

	 	•	 	Once we have year-end performance results, we will adjust the amount of your current potential target bonus in dollars, based on the company’s performance against our company-wide goals, as determined by our Board
of Directors, upon the recommendation of the Compensation Committee. Your target bonus may be adjusted up or down depending on Sage’s overall corporate performance percentage for the year. 

Bonus Determinants 
  

	 	•	 	Once your adjusted bonus target (in $$) is determined (i.e. by applying the corporate performance percentage), actual payout eligibility will be determined based on your individual performance percentage applied to the
adjusted target. Based on the results of your performance review, demonstration of core values and goal achievement, as determined by your manager under procedures and guidelines established by the Leadership Team, you will be eligible to
receive an individual payout percentage which is then applied to the adjusted target to determine your bonus payout. Notwithstanding the foregoing, in the case of the CEO, the level of individual goal achievement and bonus pay-out will be
determined by the Board of Directors with the input and recommendation of the Compensation Committee, and in the case of the members of the Leadership Team other than the CEO, the level of individual goal achievement and bonus pay-out will be
determined by the Compensation Committee with the input and recommendation of the CEO. 

 Sage Corporate Performance Goals 

 

	 	•	 	Sage Corporate Performance Goals will be defined and approved by the Board annually. After the end of the fiscal year, the Board, upon the recommendation of the Compensation Committee, will approve a percentage of total
goal achievement that will be used to determine the payout of bonuses, if any. This percentage will be used to determine the Sage bonus pool. The Compensation Committee has the discretion to adjust upward or downward the corporate
performance percentage as deemed appropriate.

	 	•	 	A more complete definition of Corporate Performance Goals and the method of calculating related bonuses may be found in the appendices of this document 

Individual Performance Goals 
  

	 	•	 	Individual goals will be agreed annually by you and your manager. 

  

	 	•	 	Your manager will determine the weighting of each individual performance goal. 

  

	 	•	 	In the case of the CEO, the Compensation Committee shall review and approve any additional corporate goals, and the weighting of such goals, that may be relevant to the compensation of the CEO. 

 

	 	•	 	There may be minimum thresholds of overall or individual goal performance that must be achieved to be eligible for a bonus. If you do not meet this threshold goal achievement you will not be eligible for any bonus
payout (corporate or individual). 

  

	 	•	 	A more complete definition of Bonus Requirements and Individual Performance Goals may be found in the appendices of this document. 

Discretion of Compensation Committee 
  

	 	•	 	Notwithstanding the foregoing, the Compensation Committee may adjust bonuses or grant discretionary bonuses to individuals under this plan based on individual performance goals or achievements and/or upon such other
terms and conditions as the Compensation Committee may in its discretion determine. 

 Performance Period 

 

	 	•	 	January 1 through December 31 for the applicable fiscal year. 

 Payment Timing 

 

	 	•	 	Sage shall make any bonus payouts within 74 days following the end of the fiscal year. 

  

	 	•	 	If multi-year Corporate Performance Goals are set, any related bonus payouts will be made within 74 days of the end of the fiscal year in which the portion of the Goal was achieved. 

Terms and Conditions 
  

	 	•	 	All of the provisions of this Bonus Incentive Plan description are subject to the attached General Terms and Conditions. In the event of any conflict between the foregoing description and the General Terms and
Conditions, the General Terms and Conditions will prevail. You should read the General Terms and Conditions carefully, and ask questions if there is any provision you do not understand. 

 General Terms and Conditions 

Approval Process/Administration of the Plan 

 
 The Bonus Incentive Plan Document has been approved by
the head of Human Resources, the CEO and the Compensation Committee. Payment under this plan will be determined after the final corporate goal achievement rating has been approved by the Board. The year-end payout will encompass goals for the
entire year. 
 Eligibility for Participation 

 
 Regular full-time employees, and those part-time
employees who are designated for participation by the head of Human Resources, will be eligible to participate in this plan unless specifically excluded. Exclusion of an otherwise eligible employee must have appropriate approvals by the CEO and the
head of Human Resources. 
 New Hire or Position Change 

 
 Bonuses to the extent otherwise payable will be
pro-rated for the applicable plan year under the following circumstances based upon the number of months that the action is effective, including partial months. The basis for calculation will be year-end salary (except in cases of movement
between full-time and part-time employment). 
 New Hire - New Hires bonus plan eligibility commences on the first day of employment
and will be prorated in the first calendar year of employment based on month of hire. If your hire date is in December, you will not be eligible for a bonus payout for that year. 

Position Change - An employee who in any calendar year moves into a position with a different bonus target may have the bonus payout
prorated based upon bonus target and salary for months in such year in each position and the timing of the movement. 
 Leaves of Absence/Disability
Leave: review and recommendation of the CEO and the head of Human Resources 
  

Any employee who takes a personal leave of absence may be eligible to receive a pro-rated bonus based on time actually worked during the plan year. Any
employee on a medical leave of absence will be eligible for a full bonus payment for up to twelve weeks of medical leave. If the medical leave extends beyond twelve weeks, the employee may not be eligible for further bonus payment while they
are on leave beyond twelve weeks. In this case, payments may be pro-rated based on time actually worked. 
 Any bonus payment discussed in this section
will only be paid based upon evaluation of Corporate and Individual performance, and after review and recommendation by the CEO, and the head of Human Resources and, with respect to Leadership Team members, also by the Compensation Committee. 

 Terminations 

 
 If an individual’s employment with Sage
terminates, for any reason, prior to the date a bonus payment is made, the individual will not be eligible to receive any bonus payment, notwithstanding any notice periods or severance payments in lieu of notice required under local law. The CEO and
the head of Human Resources may make exceptions to this requirement for employees who are not members of the Leadership Team, based on the circumstances of the termination. The Compensation Committee may make exceptions to this requirement for
Leadership Team members, if recommended by the CEO and the head of Human Resources. In situations where an employee has provided or been provided a notice of termination but has not yet terminated employment as of the date bonuses are paid, bonus
eligibility will be determined by the head of Human Resources and the CEO in the case of employees who are not members of the Leadership Team, and by the Compensation Committee in the case of members of the Leadership Team, in each case subject to
local laws. 
 Retirement/Death - An employee who retires or in the case of death of an employee, he/she may be eligible for a pro-rated payment
through the last day of month worked and will be determined on a case by case basis. Payouts will be made upon normal bonus payment schedule. Retirement is defined as ceasing to be employed by the Company upon: (a) reaching 65 years of age;
or (b) reaching 55 years of age and completing at least 10 years of service. The Compensation Committee may make exceptions in either of these situations, if recommended by the CEO and the head of Human Resources. 

Terminations and Rehire in the Same Plan Year 

 
 Employees who terminate involuntarily, and are rehired
during the same plan year, are eligible for a bonus based on all months worked during the year, including partial months. 
 Employees who terminate
voluntarily, and are rehired during the same plan year, are eligible for a bonus based only on the months worked following the rehire date. 
 All
Bonuses are Subject to Discretion of Compensation Committee 
  

Any bonus payment provided for under this Plan is completely discretionary, and is not considered earned or accrued by an employee until it is actually paid.
Eligibility to participate does not guarantee that any bonus will actually be paid for a given performance period, and in some cases an eligible employee may not receive any bonus under this Plan. 

Miscellaneous 
  

The CEO and the head of Human Resources shall review the operation of the Plan and these General Terms and Conditions. If at any time continuation of the
Plan or any of its provisions becomes inappropriate or inadvisable, the Plan or its provisions may be revised, modified, suspended or withdrawn upon approval by the Compensation Committee. The Company reserves the right to interpret the Plan in
its sole discretion. 
 All bonus payments made under the Plan shall be subject to income and employment tax withholding as required by applicable law. 

 Participants do not have any right or interest, whether vested or otherwise, in the Plan or in any award until a
bonus is actually paid. Nothing contained in the Plan or in these General Terms and Conditions shall require the Company to segregate or earmark any cash, shares of stock or other property. Neither the adoption of the Plan nor its operation
shall in any way affect the rights and power of the Company or of any subsidiary to dismiss and/or discharge any employee at any time. 
 These General
Terms and Conditions are a summary intended to assist in the administration of the Plan. In cases where the Plan or these General Terms and Conditions conflict with the rules and regulations adopted by the Board and its designated Committee, or
any severance agreement or policy providing for payment of all or a portion of the annual incentive award, those shall take precedence and be followed. 

Eligibility and participation in the Plan, inferred or written, shall not be construed as an employment contract, either expressed or implied, between the
company and the participant. It is expected that the participant will fully comply with all company requirements regarding performance and conduct at all times. Sage maintains an employment-at-will relationship with its employees such that
the employee is free to resign and the company is free to terminate the employee consistent with the policies, procedures, terms, and conditions of the company. 

 Appendices 

Corporate Performance Goals: Definition 

Corporate Performance Goals An employee may receive a bonus payment under this Incentive Plan based upon the attainment of one or more
performance objectives that are established by the Board of Directors and relate to financial and operational metrics with respect to the Company or any of its subsidiaries (the “Corporate Goals”), which may include one or more of
the following: cash flow (including, but not limited to, operating cash flow and free cash flow); sales or revenue; corporate revenue; earnings before interest, taxes, depreciation and amortization; net income (loss) (either before or after
interest, taxes, depreciation and/or amortization); changes in the market price of the Company’s common stock; economic value-added; development, clinical or regulatory milestones; acquisitions or strategic transactions; operating income
(loss); return on capital, assets, equity, or investment; stockholder returns; return on sales; gross or net profit levels; productivity; expense efficiency; margins; operating efficiency; customer satisfaction; working capital; earnings (loss) per
share of the Company’s common stock; bookings, new bookings or renewals; sales or market shares; number of customers, number of new customers or customer references; operating income and/or net annual recurring revenue, any of which may be (A)
measured in absolute terms or compared to any incremental increase, (B) measured in terms of growth, (C) compared to another company or companies or to results of a peer group, (D) measured against the market as a whole and/or as compared to
applicable market indices and/or (E) measured on a pre-tax or post-tax basis (if applicable). Further, any Corporate Goals may be used to measure the performance of the Company as a whole or a business unit or other segment of the Company, or one or
more product lines or specific markets. The Corporate Goals may differ from employee to employee, but are typically expected to apply to all employees of Sage. 

Calculating Corporate Performance Goals: Definition 

Calculating Corporate Performance Goals: Results At the beginning of each applicable performance period, the Board of Directors based on
the recommendations of the Compensation Committee will determine whether any significant element(s) will be included in or excluded from the calculation of any Corporate Performance Goal with respect to any employee. In all other respects,
Corporate Performance Goals will be calculated in accordance with the Company’s financial statements, generally accepted accounting principles, or under a methodology established by the Board of Directors at the beginning of the performance
period and which is consistently applied with respect to a Corporate Performance Goal in the relevant performance period. 
 Bonus Requirements:
Individual Goals: Definition 
 Bonus Requirements: Individual Goals Any bonuses paid to employees under this Incentive Plan
shall be based upon objectively determinable bonus formulas that tie such bonuses to one or more performance targets relating to the Corporate and Individual Performance Goals. No bonuses shall be paid to employees unless and until the Board of
Directors makes a determination with respect to the attainment of the performance targets relating to the Corporate Goals. Notwithstanding the foregoing, the Compensation Committee may adjust bonuses payable under this Incentive Plan based on
achievement of one or more individual performance objectives or pay bonuses (including, without limitation, discretionary bonuses) to executives and employees under this Incentive Plan based on individual performance goals and/or upon such other
terms and conditions as the Compensation Committee may in its discretion determine. 
 This document is intended to replace the SENIOR EXECUTIVE CASH
INCENTIVE BONUS PLAN 
 ADOPTED: April 27, 2016 

EFFECTIVE: April 27, 2016

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