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                                                                   EXHIBIT 10.13

                                 FRANKLIN SQUARE
                                COMMERCIAL LEASE

1.   BASIC LEASE PROVISIONS AND IDENTIFICATION OF EXHIBITS

                             BASIC LEASE PROVISIONS

          PREMISES: Suite 405 in 900 N. Franklin, 400, 401,402 in 920 N.
          Franklin, Including all built-in improvements presently existing in
          the Premises.

     A. LANDLORD AND ADDRESS:
     The Lumber Co. as Agent for the beneficiary of LaSalle National Trust,
     N.A., successor to Exchange National Bank of Chicago, not personally, but
     as Trustee under Trust Agreement Trust No. 21657. 900 North Franklin,
     Chicago, Illinois 60610.

     B. TENANT AND CURRENT ADDRESS: AccuMed International, Inc., 920 North
     Franklin, Suite 402, Chicago, IL 60610.

     C. DATE OF LEASE EXECUTION: February 1, 2000

     D. LEASE TERM: Four years and 7 months

     E. COMMENCEMENT DATE OF TERM: February 1, 2000

     F. EXPIRATION DATE OF TERM: September 30, 2004

     G. DATE OF OCCUPANCY: February 1, 2000

     H. MONTHLY BASE RENT: Eleven Thousand Three Hundred Seventy Six and 00/100
     ($11,376.00) (subject to adjustments provided herein) (Suite 205 - $950,
     400 - $1,672, 401 - $2,610, 402 - $6,144

     I. RENTABLE AREA OF THE PREMISES: Ten Thousand and Sixty Two. Suite 405 -
     800 sq. ft., 400 - 1,410 sq. ft., 401 - 2,670 sq. ft., 402 - 5,182 sq. ft.
     (10,062 sq. ft.)

     J. SECURITY DEPOSIT: 0 and 00/100 dollars ($0)
     $0 applied to first months rent
     $0 held for term of lease

     K. ANNUAL BASE: 2000

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     L. PURPOSE: General office use.

1.02 ENUMBERATION OF EXHIBITS
The exhibits set forth below and attached to this Lease by this reference: None
attached.

2. PREMISES AND TERM

2.01 LEASE OF PREMISES
Landlord hereby leases to Tenant and Tenant hereby accepts the Premises shown on
Exhibit A.

2.02 TERM
The term of this Lease ("Term") shall commence on the date ("Commencement Date")
which is the earlier to occur of:

     (i)  the date specified in Subsection 1.01G or
     (ii) the date Tenant first occupies all or part of the Premises.

The Term shall expire on the date ("Expiration Date") specified in Subsection
1.01F, unless sooner terminated as otherwise provided elsewhere in this Lease.

3. RENT
Tenant agrees to pay to Landlord at the office of the managing agent ("Manager")
of the Landlord, or at such other place designated by Landlord, without any
prior demand therefore and without any deduction whatsoever, base rent at the
Monthly Base Rent specified in Subsection 1.01H, and, as applicable, Adjusted
Monthly Base Rent as hereinafter defined. Monthly Base Rent is subject to
adjustment pursuant to Sections 21.02 and 21.03, and as adjusted in hereinafter
called "Adjusted Monthly Base Rent". Unless otherwise provided to the contrary
in this Lease, Adjusted Monthly Base Rent shall be paid monthly in advance on
the first day of each month of the Term, except that the first installment shall
be paid by Tenant to Landlord upon execution of this Lease by Tenant. Adjusted
Monthly Base Rent shall be prorated for partial months within the Lease in
addition to Adjusted Monthly Base Rent shall be deemed additional rent
("Additional Rent"), and Adjusted Monthly Base Rent and Additional Rent shall
hereinafter be collectively called "Rent". Tenant's covenant to pay Rent shall
be independent of every other covenant in this Lease.

4. SECURITY DEPOSIT
As security for the performance of its obligations under this Lese. Tenant upon
its execution of this Lease has paid to Landlord a security deposit, (the
"Security Deposit") in the amount specified in Subsection 1.01J. The Security
Deposit may be applied by Landlord to cure and default of Tenant under this
Lease, and upon notice by Landlord of such application, Tenant shall replenish
the Security Deposit in full by promptly paying to Landlord the amount so
applied. Within Thirty (30) days after the Expiration Date, Landlord shall
return to Tenant the balance, if any, of the Security Deposit. The Security
Deposit shall not be deemed an advance payment of Rent or measure of damages for
any

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default by Tenant under this Lease, nor shall it be a bar or defense to any
action which Landlord may at any time commence against Tenant.

5. SERVICES

5.01 LANDLORD SERVICES
     Landlord will furnish to Tenant during the term of this Lease all necessary
water for sanitary purposes used in connection with the toilets and wash basins
and showers located in the Premises. If Tenant shall require water for purposes
other than those above mentioned, Landlord may install a water meter and furnish
water to Tenant for purposes other than above named at the same rate that
Landlord shall be required to pay its supplier of water for the amount of water
indicated by said water meter as being used by Tenant.

     Should Tenant fail to pay the bills for such water, and for electric
current and gas, Landlord shall have the right to pay same, the amount whereof,
together with any sums paid by the Landlord to keep the Premises in a healthy
condition as above specified, are declared to be so much additional rent, and to
be payable with the next installment of rent due hereunder.

     Tenant shall have use of passenger elevators in common with other tenants
daily. Tenant shall have use of freight elevators in common with other tenants
during regular hours prescribed by Landlord and any other hours that may be
mutually agreed. Landlord shall not be liable for failure to supply elevator
service occasioned by the breaking down of machinery or equipment or by strikes,
accidents, unavoidable delays or causes beyond the control of Landlord. In any
event, Landlord shall make Timely Repairs to insure elevator service for Tenant
and Tenants invitees.

5.02 TENANT'S SERVICES
     Tenant shall pay for all utility service it requires directly to the
utility furnishing such services. Tenant shall also pay its own heating and
cooling cost. Tenant shall make arrangements directly with the telephone company
servicing the Building for telephone service to the Premises. Tenant shall pay
for the maintenance and replacement of all light fixtures, electrical switches,
electrical outlets and lamps located in the Premises and all bulbs, tubes
ballasts and starters utilized in the Premises. All existing lamps and lights to
be in good working order upon possession date.

5.03 ENERGY CONSERVATION
     Landlord shall have the right to institute such policies, programs and
measures as may be necessary or desirable, in Landlord's discretion, for the
conservation and/or preservation of energy or energy related services, or as may
be reasonably required to comply with any applicable codes, rules and
regulations, whether mandatory or voluntary.

6. POSSESSION, USE AND ENJOYMENT OF PREMISES

6.01 POSSESSION AND USE OF PREMISES

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     Tenant shall be entitled to possession of the Premises upon Commencement
Date. In the event of the failure of the Landlord to deliver possession of the
Premises upon the Commencement Date, neither the Landlord or its agents shall be
liable for any damages caused thereby, nor shall this Lease thereby become void
or voidable. The Premises shall not be deemed to be unready for Tenant's
occupancy or incomplete if only minor or insubstantial details of construction,
decoration or mechanical adjustments remain to be done in the Premises or any
part thereof, of if the delay in work, changes, alterations or additions
required or made by Tenant in the layout of finish of the Premises or any part
thereof. Tenant shall occupy and use the Premises for purposes indicated in
Section 1.01L only. Tenant shall not occupy or use the Premises (or permit the
use or occupy of the Premises) for any purpose or in any manner which: (a) is
unlawful or in violation of any applicable legal, governmental or
quasi-governmental requirement, ordinance or rule (including the Board of Fire
Underwriters); (b) may be dangerous to persons or property; (c) may invalidate
or materially increase the amount of premiums for any insurance affecting the
Building, and if any additional amounts of insurance premiums are so incurred,
Tenant shall pay to Landlord the additional amounts on demand; or (d) may create
a nuisance, disturb any other tenant of the Building of the occupants of
neighboring property or injure the reputation of the Building. Tenant's
acceptance of possession of the Premises shall be presumed to be Tenant's
acknowledgment that the Premises are in satisfactory condition and that no
further changes in the condition of the Premises shall be the obligation of the
Landlord, except the construction and completion of those items set forth on
EXHIBIT C attached hereto.

6.02 QUIET ENJOYMENT
     So long as Tenant shall not be in default under this Lease, Tenant shall be
entitled to peaceful and quiet enjoyment of the Premises, subject to the terms
of this Lease.

7. CONDITION OF PREMISES
     The Tenant's taking possession of the Premises shall be conclusive evidence
that the Tenant accepted the Premises in the condition existing on the date
Tenant first took possession, and that Tenant has waived all claims relating to
the condition of the Premises, except claims, if any, which relate to Landlord's
failure to complete the improvements set forth in EXHIBIT C attached hereto. No
agreement of Landlord to alter, remodel, decorate, clean or improve the Premises
or the Building , and no representation regarding the condition of the Premises
has been made by or on behalf of Landlord to Tenant, except as stated in this
Lease. At any time after the Commencement Date, upon the request from time to
time of Landlord or Landlord's mortgagee, Tenant shall execute and deliver to
Landlord or its mortgagee a standard type of estoppel certification.

8. ASSIGNMENT AND SUBLETTING

8.01 ASSIGNMENT
     Tenant shall not assign, mortgage, pledge, hypothecate or otherwise
transfer or permit the transfer of this Lease or the interest of Tenant in this
Lease, in whole or in part, by operation of law or otherwise without prior
written consent of Landlord. Such

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consent shall not be unreasonably withheld or delayed. If Tenant or the
beneficiary of Tenant is a partnership, a withdrawal or change, voluntary,
involuntary or by operation of law, of any partner or partners owning 51%,
whether by a single transaction or event or by cumulative transactions or
events, or more of the partnership interest, or the dissolution of the
partnership shall be deemed an assignment of this Lease. If Tenant, or the
beneficiary of Tenant is a corporation, any dissolution, merger, consolidation,
or reorganization of the Tenant or the sale or the transfer of a controlling
percentage of the capital stock of the tenant, whether by a single transaction
or event or by cumulative transactions or events, shall be deemed an assignment
of this lease. If the Tenant consists of more than one person, a purported
assignment, voluntary, or by operation of law, from a majority of such persons
to any of a majority of such persons to any or all of the others shall be deemed
an assignment of this Lease.

8.02 SUBLETTING
     Tenant shall not sublet the whole or any part of the Premises without
Landlord's prior written consent. Such consent shall not be unreasonably
withheld or delayed.

9. MAINTENANCE

9.01 LANDLORD'S MAINTENANCE
     Landlord shall maintain and make necessary repairs on a timely basis to the
structural elements of the Building and the electrical, plumbing, heating,
ventilating and air-conditioning systems in the Building and exterior windows
except that: (i) the cost of repairing any damage to any of the foregoing caused
by the act or neglect of Tenant, any subtenant of Tenant, or their respective
agents, employees, guests or invitees shall be paid by Tenant; and (ii) Landlord
shall not be responsible for maintenance or repair of electrical or plumbing
fixtures located within Premises. Landlord is responsible for the maintenance
and repair of in office heating and cooling units. Outside windows will be
cleaned two times per year at Landlord's expense.

9.02 TENANT'S MAINTENANCE
     Tenant, at its expense, shall keep and maintain the Premises in good order,
condition and repair (including the keeping of the Premises in clean and orderly
condition) and in accordance with all applicable legal, governmental and
quasi-governmental and insurance carrier requirements, ordinances and rules. If
Tenant fails to perform any of its obligations set forth in the Section 9,02,
Landlord, in addition to its other remedies with respect to Tenant's breach of a
covenant hereunder, may, in its dole discretion, but with prior notice to
Tenant, perform the same, and Tenant shall pay to Landlord the direct out of
pocket cost, and other costs and expenses arising from Landlord's involvement
with such repairs and replacements, therefore upon demand. The Tenant shall pay
the Landlord for overtime and for any other expenses incurred in the event
repairs, alterations decorating or other work on the Premises are not made
during ordinary business hours at the Tenant's request.

10. ALTERATIONS AND IMPROVEMENTS

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10.01 TENANT'S ALTERATIONS
     All work performed within the Premises shall be in accordance with all
applicable legal, governmental and quasi-governmental requirements, ordinances
and rules (including the Board of Fire Underwriters), and all requirements of
applicable insurance companies. All such work shall be done in a good and
workmanlike manner and with the use of good grades of materials. Tenant shall
not pledge, mortgage, hypothecate or in any way create a security interest in
and to any of the alterations and improvements provided for herein to any
creditor or third party without the prior written consent of Landlord. Tenant
shall mot perform any work without the prior written consent of Landlord. This
consent is exclusive for all Tenant furnishings. Such consent shall not be
unreasonably withheld or delayed.

10.02 LIENS
     Tenant shall not permit any lien or claim for lien of any mechanic, laborer
or supplier or any other lien to be filed against the Building, the Land, the
Premises, or any part thereof arising out of work performed, or alleged, or
alleged to have been performed by, or at the direction of, or on behalf of
Tenant. If any such lien or claim for lien is filed, Tenant shall immediately
either have such lien or claim for lien released of record or shall deliver to
Landlord a bond in form, content, amount, and issued by surety, satisfactory to
Landlord indemnifying Landlord, the Beneficiaries and others designated by
Landlord against all costs and liabilities resulting from such lien or claim for
lien and the foreclosure or attempted foreclosure thereof. If Tenant fails to
have such lien or claim for lien so released or to deliver such bond to
Landlord, without investigating the validity of such lien, may pay or discharge
the same, and Tenant shall reimburse Landlord upon demand for the amount so paid
by Landlord, including Landlord's expenses and attorneys' fees.

10.03 ACCESS
     The Tenant shall permit the Landlord to erect, use and maintain pipes,
ducts, wiring and conduits in and through the Premises. The Landlord or
Landlord's agents shall have the right to enter upon the Premises, to inspect
the same, and to make such inspections, repairs, alterations, improvements or
additions to the Premises or the Building as the Landlord may deem necessary or
desirable, and the Landlord shall be allowed to take all material into and upon
said Premises that me be required therefore, so long as Tenant is nor
unreasonable interfered with. If the Tenant shall not be personally present to
permit an entry into the Premises, when for any reason an entry therein shall be
necessary or desirable, the Landlord or Landlord's agents may enter the same by
a master key, or may forcibly enter the same, without rendering the Landlord or
such agents liable therefore (if during such entry Landlord or Landlord's agents
shall accord reasonable care to Tenant's property), and without in any manner
affecting the obligations and covenants of this Lease. Whenever possible,
Landlord will give to Tenant advanced notice of its intentions and purpose of
entry to do work. Nothing herein contained, however, shall be deemed or
construed to impose upon the Landlord any obligations, responsibility or
liability whatsoever, for the care, supervision or repair of the Building or any
part thereof, other than as herein provided. The Landlord shall also have the
right at any time without the same constituting an actual or constructive
eviction and without incurring any liability

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to the Tenant therefore, to change the arrangements and/or location of entrances
or passageways, doors and doorways and corridors, elevators, stairs, toilets or
public parts of the Building, and to close entrances, doors, corridors,
elevators or other facilities, so long as Tenant is not unreasonably interfered
with. The Landlord shall not be liable to the Tenant for any expense, injury,
loss or damage resulting from work done in or upon, or the use of, any adjacent
or nearby building, land, street or alley.

11. WAIVER OF CLAIMS AND INDEMNITY

11.01 WAIVER

          A.   Tenant's Waiver: Tenant releases Landlord and its beneficiaries,
               and their respective agents, employees and contractors from, and
               waives all claims against Landlord, Trustee and its beneficiaries
               and their respective agents, employees contractors, for damage to
               Tenant's property and loss of business, including business
               interruption, sustained by Tenant due to any cause whatsoever
               except for claims resulting from Landlord's gross negligence or
               willful misconduct. If such damage or injury is caused by the
               negligence or Landlord, Trustee or its beneficiaries, or their
               respective agents, employees or contractors, Tenant shall make a
               claim under its insurance policy as its sole remedy for such
               damage. All property belonging to Tenant or any occupant of the
               Premises that is in the building or the Premises shall be there
               at the risk of Tenant or other person only, and Landlord, Trustee
               and its beneficiaries and their respective agents, employees and
               contractors shall not be liable for damage thereto or theft or
               misappropriation thereof.

          B.   Landlord's Waiver: Landlord release Tenant and its agent,
               employees and contractors from and waives all claims against
               Tenant and its agents, employees and contractors for damage to
               Landlord's property and loss of business, including loss of
               rents, sustained by Landlord due to any cause whatsoever except
               for claims resulting from Tenant's gross negligence or willful
               misconduct.

11.02 INDEMNIFICATION

          A.   Tenant's Indemnity: Tenant agrees to indemnify, pay the costs of
               the defense of and hold harmless Landlord, Trustee and its
               beneficiaries and their respective agents, employees and
               contractors, from and against all claims, demands, actions,
               liabilities, damages, costs and expenses (including reasonable
               attorney's fees), for injuries to any persons (other than
               Landlord) and damage to or theft or misappropriation or loss of
               property (other than Landlord's) occurring in or about the
               Building and

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               arising from the use and occupancy of the Premises or from any
               activity, work or thing done, permitted or suffered by Tenant in
               or about the Premises (including, without limitation, any
               alteration by Tenant) or from any breach or default on the part
               of Tenant in the performance of any covenant or agreement on the
               part of Tenant to be performed under this lease or due to any
               other act or omission of Tenant, its subtenants, assignees,
               invitees, employees, contractors and agents. Without limiting the
               foregoing, Tenant shall indemnify, pay the costs of the defense
               of an hold Landlord Harmless from any claims, liabilities,
               damages, costs and expenses arising out of the use or storage of
               hazardous or toxic materials in the building by Tenant. If any
               such proceeding is filed against Landlord or any such indemnified
               party, Tenant agrees to pay the costs of the defense of Landlord
               or such indemnified party in such proceeding by Landlord shall
               not have the right o settle any such claims with the consent of
               Tenant.

          B.   Landlord's Waiver: Landlord agrees to indemnify, pay the costs of
               the defense and hold harmless Tenant, its agents, employees and
               contractors, from and against all claims, demands, actions,
               liabilities, damages, costs and expenses (including reasonable
               attorney's fees), for injuries to any persons (other than Tenant)
               and damage to or theft or misappropriation or loss of property
               (other than Tenant's) occurring in or about the building and
               arising from any activity, work or thing done, permitted or
               suffered by Landlord in or about the Building or from any breach
               or default on the part of Landlord in the performance of any
               covenant or agreement on Landlord's part to be performed
               hereunder or due to any other act or omission of Landlord, its
               assignees, invitees (to the extent such invitees are at the
               building only), employees, contractors and agents. If any such
               proceeding is filed against Tenant or any such indemnified party,
               Landlord agrees to pay the costs of the defense of Tenant or such
               indemnified party in such proceeding at Landlord's sole cost by
               Tenant shall not have the right to settle any claim without
               consent of Landlord.

11.02 MUTUAL WAIVER OF CLAIMS AND SUBROGATION
     Whenever (a) any loss, cost, damage or expense resulting from fire,
     explosive, or any other occurrence is incurred by either of the parties to
     this lease or anyone claiming by, through or under them in connection with
     the Premises and (b) such party is then either covered in whole or in part
     by insurance with respect to such loss, cost, damage or any other expense,
     or required under this lease to be so insured, then the party so insured
     (or so required) hereby release the other party from any liability the
     other party may have on account of such loss, cost, damage, or expense to
     the extent of any amount recovered by reason of such insurance (or which
     could have been recovered had insurance been carried as so required) and

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     waives any right of subrogation which might otherwise exist in or accrue to
     any person on account thereof (provided that such releases of liability and
     waiver of the right of subrogation shall not be operative in any case of
     increased cost, the other party shall have the right, within (30) days
     following written notice, to pay such increased cost, thereupon keeping
     such release and waiver in full force and effect). Whether the party
     released form liability hereunder is Landlord or Tenant, said term
     "Landlord" or "Tenant", respectively, and its respective trustees,
     beneficiaries, agents, partners, shareholders, officers, directors and
     employees.

12. LANDLORD'S REMEDIES

12.1 All right and remedies of the Landlord herein enumerated shall be
cumulative and none shall exclude any other right or remedy allowed by law.

12.2
          A.   If the Tenants defaults in any payment of Rent, and the Tenant
               does no cure the default within (10) days after demand for
               payment of such Rent or if the Tenant defaults in the prompt and
               full performance of any other provisions of this Lease, and the
               Tenant does not cure the default with thirty (30) days after
               written demand by the Landlord that the default be cured (unless
               the default involves hazardous condition, which shall be cured
               forthwith); or if the leasehold interest of the Tenant be levied
               upon under execution or be attached by process of law, or if the
               Tenant makes an assignment for the benefit of creditors or admits
               its inability to pay its debts generally, or if a receiver be
               appointed for any property of the Tenant, or if the Tenant
               abandons the Premises, then, and in any such event, the Landlord,
               may if the Landlord so elects by not otherwise, and with or
               without notice of such election, and with or without any demand
               whatsoever, either forthwith terminate this Lease and the
               Tenant's right to possession of the Premises or, without
               terminating this Lease, forthwith terminate the Tenant's right to
               possession of the Premises, Except for defaults in payment of
               Rent, if Tenant is diligently proceeding to cure any default he
               shall have the ability to do so for up to sixty (60) days, after
               which all Landlords remedies will proceed.

          B.   Upon termination of this Lease, whether by lapse of time or
               otherwise, or upon any termination of the Tenant's right to
               possession without termination of the Lease, the Tenant shall
               surrender possession and grants to the Landlord full and free
               license to enter into and upon the Premises in such event with or
               without process of law and to repossess the Landlord of the
               Premises and to remove any and all property therefrom, using such
               force as may be necessary, without being deemed in any manner
               guilty of trespass, eviction or forcible entry or detainer, and
               without relinquishing the Landlord's rights to Rent or any other
               right given to the Landlord hereunder or by operation of law.

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          C.   (Intentionally omitted)

          D.   If any involuntary action or proceeding under any section or
               sections of any bankruptcy act in any court or tribunal shall
               adjudge or declare Tenant insolvent or unable to pay Tenant's
               debts, or if any voluntary petition or similar proceeding under
               any section or sections of any bankruptcy act shall be filed by
               Tenant in any court or tribunal to declare Tenant insolvent or
               unable to pay Tenant's debts, then and in any such event Landlord
               may, if Landlord so elects by note otherwise, and with or without
               notice of such election, and with or without entry or other
               action by Landlord, forthwith terminate this Lease, and
               notwithstanding any other provision of this Lease, Landlord shall
               forthwith upon such termination be entitled to recover damages in
               an amount equal to the then present value of the Rent for the
               remainder of the Term, less the fair rental value of the Premises
               for the remainder of the Term.

          E.   Any and all property which may be removed from the Premises by
               the Landlord pursuant to the authority of the Lease or of law, to
               which the Tenant is or may be entitled, may be handled, removed
               or stored by the Landlord at the risk, cost and expense of the
               Tenant, and the Landlord shall in no event be responsible for the
               value, preservation or safekeeping thereof. The Tenant shall pay
               to the Landlord, upon demand, any and all expenses incurred in
               such removal and all storage charges against such property so
               long as the same shall be to the conclusively presumed to have
               been conveyed by the Tenant to the Landlord under this Lease as a
               bill of sale without further payment or credit by the Landlord to
               the Tenant.

          F.   The Tenat shall pay upon demand all the Landlord's costs, charges
               and expenses, including the fees of counsel, agents and others
               retained by the Landlord, incurred in enforcing the tenants
               obligations hereunder or incurred by the Landlord in any
               litigation, negotiation or transaction in which the Tenant causes
               the Landlord, without the Landlord's fault, to become involved or
               concerned.

13. SURRENDER OF PREMISES
     Upon expiration or termination of this Lease or termination of Tenant's
right of possession of the Premises, or any part thereof, Tenant shall surrender
and vacate the Premises immediately and deliver possession thereof to Landlord
in a clean, good and tenatable condition, ordinary wear and tear excepted. Upon
any termination, Tenant shall be entitled to remove from the Premises all
movable personal property of Tenant, provided Tenant shall immediately repair
all damages resulting from such removal and shall restore the Premises to its
original condition, ordinary wear and tear excepted. In the event possession of
the Premises is not immediately delivered to Landlord or if Tenant shall fail to
remove all of Tenant's movable personal property. As aforesaid, Landlord may
remove any of such property therefrom without any liability to Tenant,

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and at Tenant's expense. All movable personal property which may be removed from
the Premises by Landlord shall be conclusively presumed to have been abandoned
by Tenant, and title thereto shall pass to Landlord without any cost or credit
therefore, and Landlord may, at its option ant at Tenant's expense, story and/or
dispose of such property.

14. HOLDING OVER

     Tenant shall pay Landlord 1.5 time the latest adjusted Monthly Base Rent
plus Operating expenses then applicable for each month or portion thereof Tenant
retains possession of the Premises, or any portion thereof, after the expiration
or termination of this Lease, and also shall pay all damages sustained by
Landlord by reason of such retention of possession. The provisions of the
Article shall not constitute a waiver by Landlord of any re-entry rights of
Landlord herein before or by law provided. If Tenant retains possession of the
Premises, or any part thereof, for twenty (20) days after the written notice to
Tenant, but not otherwise, such holding over shall constitute a renewal of the
Lease for a period of One month specified by Landlord at Landlord's option on
the sane terms and condition, except that the Adjusted Monthly Base Rent shall
be increased by 125% of the latest Adjusted Monthly Base Rent, plus any
subsequent escalations. Should Tenant wish to cancel this holdover portion of
this Lease, Tenant must give to Landlord Four months advance written notice of
its intent to cancel this lease.

15. DAMAGE BY FIRE OR OTHER CASUALTY

15.01 UNTENANTABILITY
     (Intentionally omitted)

15.02 DAMAGE BY TENANT
     In the event the Prmises or the Building is damaged by fire or other
casualty resulting from the act or neglect of Tenant, its agents, contractors,
employees or invitees, Tenant shall not be released from any of its obligations
hereunder including, without limitation, its duty to repair the Premises and its
liability to Landlord for damages caused by such fire or other casualty and its
duty to pay Rent, which Rent shall not be abated. Tenant acknowledges that
Landlord shall be entitled to the full proceeds of any insurance coverage,
whether carried by Landlord or Tenant, for damage to alternations, additions,
improvements or decorations provided by Landlord either directly or through an
allowance to Tenant (whether by rent abatement or otherwise).

16. TENANT'S INSURANCE

16.01 Tenant, at Tenant's expense, agrees to purchase and maintain in force
during the Term: (i) Comprehensive General Liability Insurance on an occurrence
basis with minimum limits of liability in an amount of $500,000 for bodily
injury, personal injury or death to any one person and $500,000 for bodily
injury, person injury or death to more than one person, and $100,000 with
respect to damage to property, including water and sprinkler damage; and (ii)
Casualty insurance to cover his personalty.

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16.02 The policies referred to in Section 16.1 shall name Landlord, the
Beneficiaries, the Manager and their respective agents and employees as
additional insureds; and shall contain the following provisions and
endorsements: (i) that such insurance may not be canceled or amended without
thirty (30) days prior written notice to Landlord, the Beneficiaries and the
Manager; (ii) an express waiver of any right of subrogation by the insurance
company against Landlord, the Beneficiaries, the Manager and their respective
agents and employees; and (iii) that the policy shall not be invalidated should
the insured waive in writing prior to a loss, any or all rights of recovery
against any other party for losses covered by such policies.

16.03 Tenant shall deliver to Landlord, certificates of insurance of all
policies and renewals thereof to be maintained by Tenant hereunder, no less than
ten (10) day prior to the Commencement Date and note less that ten (10) days
prior to the expiration date of each policy. Provided that the insurance
policies of Tenant will not be invalidated nor will the right of the insured to
collect the proceeds payable under such policies be adversely affected by the
waiver contained in the following portion of this sentence, Tenant hereby
expressly waves all rights of recovery which it might otherwise have against
Landlord, the Beneficiaries, the Manager or their agents, and employees, for
loss or damage to person, property or business to the extent that such loss or
damage is covered by valid and collectible insurance policies, notwithstanding
that such loss or damage may result form negligence of Landlord, the
Beneficiaries, the Manager or their agents or employees. Tenant shall use its
best efforts to obtain from its insurer the right to waive claims as set forth
in the preceding sentence without thereby invalidating its insurance or
affecting its right to proceeds payable thereunder.

17. RULES AND REGULATIONS

18. LANDLORD'S RIGHTS
     Landlord shall have the following rights exercisable without notice (except
as expressly provided to the contrary in this Lease), without liability to
Tenant for damage for injury to persons, property or business and without being
deemed an eviction or disturbance of Tenant's use or possession of the Premises
or giving rise to any claim for setoff or abatement of Rent: (i) To change the
Building's name or street address upon ninety (90) days prior written note to
Tenant; (ii) To install, affix and maintain all signs on the exterior and/or
interior of the Building; (iii) To designate and/or approve prior to
installation, all types of signs, window shades, blinds, drapes, awnings or
other similar items, or other similar items, and all internal lighting that may
be visible from the exterior of the Premises or the public corridors of the
Building; (iv) To display the Premises to prospective tenants at reasonable
hours during the last six (6) months of the Term; (v) To change the arrangement
of entrances, doors, corridors, elevators and stairs in the Building, provided
that no such change shall materially adversely affect access to the Premises;
(vi) To grant to any party the exclusive right (to the extent permitted by law)
to conduct any business or render any service in or to the Building, provided
such exclusive right shall not operate to prohibit Tenant from using the
Premises for the purposes permitted hereunder; (vii) To prohibit the placing of
vending or dispensing

                                       12
<PAGE>   13

machines of any kind in or about the Premises; (viii) To have access for
Landlord and other tenants for the Building to any mail chutes and boxes located
in or on the Premises according to the rules of the United States Post Office;
(ix) To close the Building after normal business hours, except that Tenant and
its employees and invitees shall be entitled to admission at all times, under
such regulations as Landlord prescribes for security purposes; (x) To take any
and all reasonable measures, including inspections and repairs to the Premises
or to the Building, as may be necessary or desirable in the operation or
protection thereof; (xi) To retain at all times master keys or passkeys to all
doors in and to the Premises; (xii) To install, operate and maintain a building
security system which monitors, by close circuit television or otherwise, all
persons entering and leaving the Building and all public areas of the Building
including, but not limited to, elevators and staircases; and (xiii) To install
and maintain pipes, ducts, conduits, wires and structural elements located in
the Premises which serve other parts of the Building.

19. MORTGAGE
     Landlord may execute and deliver a mortgage(s) or trust deed(s) in the
nature of a mortgage, both sometimes hereinafter referred to as "Mortgage"
against the Building or Land or any part thereof or interest therein, and may
sell and lease back the Land. This Lease and the rights of Tenant hereunder
shall be and are hereby made expressly subject and subordinate at all times to
all such Mortgages and ground leases, now or hereafter existing an all
amendments, modifications and renewals thereof and extensions, consolidations or
replacements thereof, and to all advances made or hereafter to be made upon the
security thereof. Landlord agrees to obtain in conjunction with any mortgage
placed against Building subsequent to date hereof an agreement by mortgagee to
refrain from disturbing tenancy or tenant so long as Tenant is not in default
hereunder.

20. NOTICES
     All notices required or permitted to be given hereunder shall be in writing
and shall be deemed given and delivered, whether or not received, when
personally delivered, when deposited in the United States Mail, postage prepaid
and properly addressed, certified mail, return receipt requested, at the
addresses for Landlord indicated in Section 1.01(B), or such other address as
Landlord shall designate by written notice to Tenant; and (ii) To Tenant: At the
address specified in Subsection 1.01(C) prior to the Commencement Date, and at
the Premises after the Commencement Date, or such other address as Tenant shall
designate by written to Landlord.

21. ADJUSTMENTS TO MONTHLY BASE RENT

21.01 DEFINITIONS
     For the purposes of this article 21, the following words and phrases shall
have the following meanings:
A.   "Adjustment Date" shall mean February 1, 2001 and each subsequent February
     1 falling with the term.
B.   "Initial Adjustment Year" shall mean the calendar year 2001.

                                       13
<PAGE>   14

C.   "Adjustment Year" shall mean the calendar year in which the `Initial
     Adjustment Date as defined herein below falls and each subsequent calendar
     year during which an Adjustment Date falls.

D.   "Adjustment Monthly Base Rent" shall mean rental (exclusive of Additional
     Rent) as from time to time computed and estimated under Sections 21.02 and
     21.03 herein below, and shall mean "Monthly Base Rent" for all periods of
     time during which no adjustment has been applied.

E.   "Tax expense" shall mean and include all Federal, State and Local
     governmental taxes, assessments and charges (including transit district
     taxes or assessments) of every kind or nature, whether general, special,
     ordinary or extraordinary, which Landlord shall pay or become obligated to
     pay because of or in connection with the ownership, leasing, management,
     control or operation of the Building and the Land, or of the personal
     property, fixtures, machinery, equipment, systems and apparatus located
     therein or used in connection therein or used in connection therewith
     (including reasonable attorney's fees) paid by Landlord during such year.
     If a special assessment payable in installments is levied against the Land,
     Taxes for any year shall include only installments of such assessment and
     any interest payable or paid during such year. Taxes shall not include any
     Federal, State or Locales sales use franchise, capital stock, inheritance,
     general income, gift or estate taxes, except that if a change occurs in the
     method of taxation resulting in whole or in part the substitution of such
     taxes, or any other assessment, for any Taxes as above defined, such
     substituted taxes or assessments shall be included in Taxes.

21.02 ADJUSTMENTS
A.   On February 1, 2001 and on each Adjustment Date thereafter, adjusted
     Monthly Base Rent shall be increased by an amount equal to 5%.

B.   Effective as of February 1, 2001 ("Initial Adjustment Date") and on each
     February 1 falling within the Term, Adjusted monthly base rent shall be
     increased by an amount equal to 1/12th of the product of the Rentable Area
     of the Premises (as specifiedin subsection 1.01I), multiplied by the amount
     by which Per Square Foot Tax Expenses exceeds the actual Tax Expenses Paid
     during the Calendar year 2000.

21.03 PROJECTIONS
     FOR PURPOSES OF CALCULATING Tax Expenses for any Adjustment year, including
the Initial Adjustment Year, Landlord shall deliver to Tenant a written
statement (1) setting forth the Projections of Tax Expenses for the adjustment
Year in which such Adjustment Base Rent based on such Projections to become
effective as of said adjustment date; provided however that the failure of
Landlord to provide any such statement shall not relieve Tenant from it
obligation to continue to pay Adjusted Monthly Base Rent reflected thereby
effective retroactively to the most recent preceding Adjustment Date.

                                       14
<PAGE>   15

21.04 READJUSTMENTS
     On or about April 1st following the end of each Adjustment Year, or at such
later time as Landlord shall be able to determine the actual amounts of Tax
Espenses for the Adjustment Year last ended, Landlord shall notify Tenant in
writing of such actual amounts, if the total Adjusted Monthly Base Rent paid by
Tenant during such Adjustment year exceeds the amount thereof payable for such
year based upon actual Tax Expenses for such Adjustment Year, the Landlord shall
credit such excess to Installments of Adjusted Monthly Base Rent payable after
the date of Landlord's notice until such excess has been exhausted, of if this
lease shall expire prior to full application of such excess, Landlord shall pay
to Tenant the balance thereof not theretofore.

21.05 NO DECREASES IN MONTHLY BASE RENT
     Notwithstanding anything to the contrary contained in this Lease, Adjusted
Monthly Base Rent shall not be adjusted or decreased below the amount set forth
in Subsection 1.01H.

22. MISCELLANEOUS

22.01 LATE AND PENALTY CHARGES
     All rent and other payments due from Tenant to Landlord which are
delinquent by more than ten (10) days shall bear interest at the rate of one and
one-half percent (1-1/2%) per month, not prorated, from time to time, whichever
is less, from the date due until paid. Tenant shall also pay to Landlord on
demand a penalty charge of $25.00 for each check delivered to Landlord for Rent
or other payments due hereunder, which is not honored by the institution on
which it is drawn.

22.02 ENTIRE AGREEMENT
     This Lease and the Exhibits attached hereto contain the entire agreement
between Landlord and Tenant concerning the Premises and there are no other
agreements, either oral or written.

22.03 ACCORD AND SATISFACTION
     No payment by Tenant or receipt by Landlord of a lesser amount than any
installment or payment of Rent due shall be deemed to be other than on account
of the amount due, and no endorsement or statement on any check or any letter
accompanying any check or payment of Rent shall be deemed an accord and
satisfaction, and Landlord may accept such check or payment without prejudice to
Landlord's right to recover the balance of such installment or payment of Rent
or pursue any other remedies available to Landlord. No receipt of money by
Landlord form Tenant after the termination of this Lease or Tenant's right of
possession of the Premises shall reinstate, continue or extend the Term.

22.04 LANDLORD'S OBLIGATION ON SALE OF BUILDING

                                       15
<PAGE>   16

     In the event of any sale or other transfer of the Building, Landlord and
the seller or transferor (and the beneficiaries of any selling or transferring
land trust) shall be entirely freed and relieved of all agreements and
obligations of Landlord hereunder accruing or to be performed after the date of
such sale or transfer, provided that Landlord sells the Building to a bona fide
purchaser and that the new landlord agrees to assume the liabilities and
responsibilities under this Lease.

22.05 BINDING EFFECT
     This Lease shall be binding upon and insure to the benefit of Landlord and
Tenant and their respective heirs, legal representatives, successors and
permitted assigns.

22.06 FORCE MAJEURE
     Landlord shall not be deemed in default with respect to any of the terms,
covenants and conditions of this Lease on Landlord's part to be performed, if
Landlord fails to timely perform same and such failure is due in whole or in
part to any cause beyond the reasonable control of Landlord, other than for
those matters set forth in Section 6.01.

22.07 CAPTIONS
     The Article and Section captions in this Lease are inserted only as a
matter of convenience and in no way define, limit, construe, or describe the
scope or intent of such Articles and Sections.

22.08 APPLICABLE LAW
     This Lease shall be construed in accordance with the law of the State of
Illinois.

22.09 TIME
     Time is of the essence of this Lease and the performance of all obligations
hereunder.

22.10 LANDLORD'S RIGHT TO PERFORM TENANT'S DUTIES
     If Tenant fails to timely perform any of its duties under this Lease,
Landlord shall have the right (but not the obligation), after the expiration of
any grace period elsewhere under this Lease expressly granted to Tenant for the
performance of such duty, to perform such duty on behalf and the expense of the
Tenant without further prior notice to Tenant.

22.11 PARTIAL INVALIDITY
     If any term, covenant, or condition of this Lease or the application
thereof to any person or circumstance shall, to any extent, be invalid or
unenforceable, the remainder of the Lease, or the application of such term,
covenant or condition to persons or circumstances other than those as to which
it is held invalid or unenforceable, shall not be affected thereby and each
term, covenant and condition of this Lease shall be valid and be enforced to the
fullest extent permitted by law.

22.12 RIDERS

                                       16
<PAGE>   17

     All riders attached hereto and executed both by Landlord and Tenant shall
be deemed to be part hereof and hereby incorporated herein.

     INWITNESS WHEREOF, this Lease has been executed as of the date set forth in
Subsection 1.01D hereof.

The Lumber Company                         AccuMed International, Inc.

By: /s/ JOHN BAUCHWITZ                     By: /s/ PAUL F. LAVALLEE
    -----------------------                    -----------------------------
Its:        Agent                             Its:  Chairman and CEO
      ---------------------                     ----------------------------

                                       17
<PAGE>   18

                                    Exhibit 1

This is the first of two exhibits to the FRANKLIN SQUARE COMMERCIAL LEASE
(Lease) dated as of February 1, 2000 between AccuMed International, Inc.
(Tenant) and The Lumber Company as Agent for the beneficiary of LaSalle National
Trust, N.A., not personally, but as Trustee under Trust Agreement Trust No.
21657 (Landlord).

The following are modifications to the Lease:

     Page 1, point L. Suite 405, 900 North Franklin, shall be permitted to be
     used for both general office as well for a machine shop, its current use
     for Tenant. Suite 401, 920 North Franklin shall be permitted to be used for
     both general office use as well as for assembly work.

     Page 8, point 12 C. Point C is modified in whole as follows: If the
     Landlord elects to terminate the Tenant's right to possession only, without
     terminating the Lease, the Landlord may, at the Landlord's option, enter
     into the Premises, remove the tenant's sign and other evidences of tenancy,
     and take and hold possession thereof as provided in Subsection 12.01B,
     without such entry and possession terminating the Lease or releasing the
     Tenant, in whole or in part, from the Tenant's obligation to pay the Rent
     hereunder for the full Term. Upon and after entry into possession without
     termination of the Lease, the Landlord shall make a reasonable effort to
     relet the Premises or any port thereof for the account of the Tenant to any
     person, firm or corporation other than the Tenant for such rent, fir such
     time and upon such terms as the Landlord may reasonably determine, and the
     Landlord shall not be required to accept any tenant offered by the Tenant
     or to observe any instructions given by the Tenant about such reletting. In
     any such case, the Landlord may make reasonable repairs, alterations and
     additions in or to the Premises and redecorate the same to the extent
     deemed by the Landlord necessary or desirable, and the Tenant shall, upon
     demand, pay the reasonable expenses in reletting. If the consideration
     collected by the Landlord upon any such reletting for the Tenant's account
     is nor sufficient to pay monthly the full amount of the Rent reserved in
     this redecorating and the Landlord's expenses, the tenant shall pay to the
     Landlord the amount of each monthly deficiency upon demand.

     Page 10, point 15.01. Point 15.01 is modified in whole as follows: If the
     Building (including machinery or equipment used in its operation) or the
     Premises are made substantially untenantable by fire or other casualty,
     either Party may elect to: (i) terminate this Lease as of the date of the
     fire or other casualty by giving the other party written notice thereof
     within ninety (90) days after said date: or (ii) in the case of the Lessor,
     assuming the Tenant has not given notice to terminate in sub paragraph
     15.01 (i), above, proceed to repair or restore the Building or the
     premises, other than leasehold improvements and personal

<PAGE>   19

     property paid for or installed by Tenant. Rent payments for the premises
     during this re-building period shall abate.

This lease Exhibit 1 is signed as of February 1, 2000.

     The Lumber Company                   AccuMed International, Inc.

     BY /s/ JOHN BAUCHWITZ                  BY /s/ PAUL F. LAVALLEE
        --------------------                   ---------------------------
     Name:  John Bauchwitz                  Name:  Paul F. Lavallee
     Title: Agent                           Title: Chairman and
                                                   Chief Executive Officer

<PAGE>   20

                                    EXHIBIT 2

                     RELEASE OF LEASED SPACES AND SETTLEMENT

This is the second of two exhibits to the FRANKLIN SQUARE COMMERCIAL LEASE
(Lease) dated as of February 1, 2000 between AccuMed International, Inc.
(Tenant) and The Lumber Company as Agent for the beneficiary of LaSalle National
Trust, N.A., not personally, but as Trustee under Trust Agreement Trust No.
21657 (Landlord).

1.   The lease dated July 12, 1994, as supplemented and amended, with respect to
     the following suites in 900 North Franklin Street, Chicago, Illinois 60610,
     numbers 206, 401, 501, 502/503, 504, 505, are terminated as of January 31,
     2000. This termination is conditioned on the concurrent commencement of a
     lease for suite 405 in 900 North Franklin Street and suites 400, 401 and
     402 in 920 North Franklin Street.

2.   The lease of suite 401 in 920 North Franklin building is for a lease rental
     rate which is the same as that existing on suite 206 in 900 North Franklin
     Street.

3.   The sum of $60,000 will be paid by AccuMed International, Inc. ("Lessee")
     over a nine-month period at a rate of $6,666.66 per month commencing March
     1, 2000 and ending with the payment of November 1, 2000.

4.   The cost of the buildout for Suite 600 in 900 North Franklin, to be
     occupied by City Access Providers, in lieu of occupancy of suite 401 in
     that same building will be $10,000 and will be paid by Lessee in two equal
     installments of $5,000 commencing February 21, 2000 and concluding with the
     payment on March 21, 2000.

5.   Lessee will pay the rent difference between suites 600 and 401 in 900 North
     Franklin Street in the amount of $16,848 of which $8,424 shall be payable
     April 1, 2000 and $8,424 one year later.

6.   Lessor, The Lumber Com., will waive the provisions of that letter dated
     June 25, 1996, regarding "Letter of Credit for Future Restoration of
     Stairwell" signed by Mark Santor, Lessee's then current Chief Financial
     Officer. (Copy of Letter attached)

This lease Exhibit 2 is signed as of February 1, 2000

     The Lumber Company                      AccuMed International, Inc.

     BY /s/ JOHN BAUCHWITZ                   BY /s/ PAUL F. LAVALLEE
        ------------------------                ------------------------
     Name:  John Bauchwitz                   Name:  Paul F. Lavallee<PAGE>   1

                                                                   EXHIBIT 10.31

October 3, 2000

VIA FAX
(631) 752-3558

Michael Strauss
Chairman and Chief Executive Officer
CellMetrix, Inc.
1800 Walt Whitman Road
Melville, NY  11747   USA

Dear Michael:

This letter confirms the mutual termination of the Patent and Technology License
and Registration Rights Agreement between AccuMed International, Inc.
("AccuMed") and BCAM International, Inc. (renamed CellMetrix, Inc. "CellMetrix")
dated March 29, 2000, as amended by a letter agreement dated August 11, 2000
(the "Agreement"). Such termination was effective as of September 1, 2000.
Section 9.5 of the Agreement specifies the provisions of the Agreement which
survive its termination and remain in full force and effect.

AccuMed International, Inc.

By:   /s/ NORMAN J. PRESSMAN
    ------------------------------------------
      Norman J. Pressman, Ph.D.
      President and Chief Scientific Officer

Agreed and acknowledged:
CellMetrix, Inc.

By: /s/ MICHAEL STRAUSS                     Date: October 3, 2000
    ------------------------------                ------------------------------
      Michael Strauss
      Chairman and Chief Executive Officer

(Please return executed confirmation to sender via fax)

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