Document:

Exhibit
4.9

 

	NUMBER	 	UNITS
	 	 	 
	U-__________	 	 
	 	 	 
	 	 	 
	SEE
    REVERSE FOR CERTAIN DEFINITIONS	 	 

 

 

INCORPORATED
UNDER THE LAWS OF DELAWARE

 

CUSIP
70387R 304

 

UNITS
CONSISTING OF ONE SHARE OF COMMON STOCK AND

ONE
SERIES Z WARRANT

 

THIS
CERTIFIES THAT ________________________ is the owner of _______________ Units.

 

Each Unit (“Unit”)
consists of one (1) share of common stock, par value $.001 per share (“Common Stock”), of PAVmed Inc., a Delaware
corporation (the “Company”), and one (1) Series Z Warrant (the “Series Z Warrant(s)”). Each Series
Z Warrant entitles the holder to purchase one share of Common Stock for $3.00 per share from the date the Series Z
Warrant is issued through its expiration on April 30, 2024, or earlier upon certain redemption provisions. The Common Stock and
Series Z Warrant(s) comprising the Unit(s) will not trade as a separate security for up to ninety days after the date of
issuance. The terms of the Series Z Warrants are governed by a Warrant Agreement, dated as of April 2, 2018, between the
Company and Continental Stock Transfer & Trust Company, as Warrant Agent, and are subject to the terms and provisions contained
therein, all of which terms and provisions the holder of this certificate consents to by acceptance hereof. Copies of the Warrant
Agreement are on file at the office of the Warrant Agent at 1 State Street Plaza, 30th Floor, New York, New York 10004,
and are available to any Series Z Warrant holder on written request and without cost.

 

This
certificate is not valid unless countersigned by the Transfer Agent and Registrar of the Company.

 

Witness
the facsimile seal of the Company and the facsimile signatures of its duly authorized officers.

 

	Dated:

                                                                                 
		 
	CHAIRMAN		SECRETARY

 

    	 	 	 

    	 

    

 

PAVmed
Inc.

 

The
Company will furnish without charge to each shareholder who so requests, a statement of the powers, designations, preferences
and relative, participating, optional or other special rights of each class of stock or series thereof of the Company and the
qualifications, limitations, or restrictions of such preferences and/or rights.

 

The
following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were
written out in full according to applicable laws or regulations:

 

	TEN
    COM –	as
    tenants in common	UNIF
    GIFT MIN ACT -	_____
    Custodian ______
	TEN
    ENT –	as
    tenants by the entireties	 	(Cust)	(Minor)

	JT
    TEN –	as
    joint tenants with right of survivorship	under
    Uniform Gifts to Minors
	 	and
    not as tenants in common	Act
    ______________
	 	 	 	(State)	 

 

Additional
Abbreviations may also be used though not in the above list.

 

For
value received, ___________________________ hereby sell, assign and transfer unto

 

	PLEASE
    INSERT SOCIAL SECURITY OR OTHER	 	 
	IDENTIFYING
    NUMBER OF ASSIGNEE	 	 
	 	 	 
	 	 	 
	 	 	 

 

 

 

(PLEASE
PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

 

 

 

 

	 	Units

 

represented
by the within Certificate, and do hereby irrevocably constitute and appoint

 

	 	Attorney

to
transfer the said Units on the books of the within named Company will full power of substitution in the premises.

 

	Dated
    	 	 

 

	 	 	 
	 	Notice:	The
    signature to this assignment must correspond with the name as written upon the face of the certificate in every particular,
    without alteration or enlargement or any change whatever.

 

Signature(s)
Guaranteed:

	 	 

THE
SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION

(BANKS,
STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH

MEMBERSHIP
IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM,

PURSUANT
TO S.E.C. RULE 17Ad-15).Exhibit

Exhibit 10.2

Amendment No. 1 to Sales Agreement

THIS AMENDMENT NO. 1 TO SALES AGREEMENT (this “Amendment”) is made effective as of January 1, 2010 by and between NTP Radioisotopes (Pty) Ltd., a commercial company registered and existing under the laws of the Republic of South Africa, having its registered office at Building 1700, Pelindaba, Church Street West Extension, Brits District, North West Province of South Africa (“NTP”), and Lantheus Medical Imaging, Inc., a corporation organized and existing under the laws of Delaware with a place of business at 331 Treble Cove Road, North Billerica, Massachusetts, United States of America 01862 (“Lantheus”).

WHEREAS:

		
	1.
	NTP and Lantheus entered into a Sales Agreement effective as of April 1, 2009 (the “Original Agreement”);

		
	2.
	Since such effective date, the global molybdenum-99m crisis has become acute; and

		
	3.
	NTP and Lantheus wish to amend the Original Agreement to increase the committed volume levels and specify the pricing for such increased committed volume levels through July 31, 2010;

NOW, THEREFORE, in consideration of the mutual promises and covenants hereinafter set forth, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

1.  Definitions.  Terms defined in the Original Agreement and not otherwise defined herein are used herein with the meanings so defined.

2.  Amendments.

		
	2.1
	Section 2.1 of the Original Agreement is hereby amended by deleting in its entirety said Section 2.1 and replacing therewith the following:

		
	2.1
	Lantheus shall buy from NTP, and NTP shall supply to Lantheus, a fixed volume of Product on a regular weekly basis to be supplied and delivered to John F. Kennedy International Airport, Jamaica, New York (“JFK”) or Logan International Airport, Boston, Massachusetts (“BOS”) (or other mutually agreed upon delivery location) on a mutually agreed schedule with follow-on trucking delivery to the Lantheus facility in North Billerica, Massachusetts.  Lantheus shall provide NTP with notice of its intention to change such location at least forty-five (45) days in advance of the required 

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inception date of such changes.  Subject to the last sentence of this Section 2.1 and to Section 5.1, such fixed volume shall be as set forth immediately below, which volume may be changed by mutual written agreement of the parties:

	
		
	Time Period
	Average curies per week with a six (6) day reference, such average calculated on a calendar month-by-calendar month basis

	January-February 2010
	1,300 curies per week

	March-April 2010
	1,000 curies per week

	May-June 2010
	900 curies per week

	July 2010
	600 curies per week

	August 2010 and thereafter
	1,400 curies per week

NTP shall be responsible to ensure that the full weekly quota of Mo-99 is delivered to Lantheus other than during scheduled outages for routine maintenance, unscheduled outages or failures of the production lines of NTP and its Subcontractor (i.e., under conditions of normal operations prevailing at NTP and its Subcontractor’s facilities).  At the discretion of the Account Manager at NTP (“Account Manager”), such material shall be supplied by NTP or its Subcontractor.  Lantheus shall be advised in a timely way of the manner in which supply obligations hereunder will be allocated among NTP and its Subcontractor.  NTP will schedule deliveries to Lantheus so as to compensate for scheduled outages at either facility in such a way that the full supply quota will be maintained under such circumstances.  In the case of unscheduled outages or production line failures for whatever reason (and for Events of Force Majeure (as hereinafter defined)), Lantheus will receive a share of Product available that is not less than that which is directly proportional to its average share of the total weekly purchasing (averaged over the preceding thirty (30) days) from NTP and its Subcontractor.  NTP has established and shall maintain relationships with air carriers for the Lantheus route such that the probability of a Lantheus shipment being refused by the carrier shall be highly improbable.  NTP shall liaise (via the Account Manager at NTP) with its Subcontractor, taking into account the reactor production and maintenance schedules of each facility, and supply Lantheus thirty-five (35) days in advance of the first delivery of a month, the supply schedule for the following month detailing clearly which supplier (NTP or a Subcontractor) will supply such delivery.  For clarity and as an example, NTP will provide Lantheus the March 2010 supply schedule on 27 January 2010.  This supply schedule will be binding on NTP and its Subcontractor and will be used by Lantheus to register each shipment with applicable U.S. governmental authorities as dictated by U.S. regulations.  If the airport of delivery is JFK, then Product will be available for pick-up by 

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Lantheus no later than 12:00 Noon.  If the airport of delivery is BOS, then Product will be available for pick-up by Lantheus no later than 3:00PM.  Pick-up time for any other delivery location will be mutually agreed upon.

Notwithstanding the foregoing and without limiting the rights of Lantheus elsewhere in this Agreement, including, without limitation, pursuant to the termination provisions of Section 11, to the extent NTP does not or cannot deliver the quantities specified in this Section 2.1 on a weekly basis in a reliable matter or on a monthly basis in accordance with the terms of this Agreement, then from and after April 1, 2010  Lantheus shall have the sole right, after giving NTP thirty (30) days prior written notice, to reduce the fixed volumes specified in this Section 2.1 to a volume or  volumes less than otherwise set forth but not less than four hundred (400) curies per week for the duration of the time periods specified.    

2.2    Section 2.2 of the Original Agreement is hereby amended by deleting from the first sentence thereof the words “regular 400 6-day Ci per week” and replacing therewith the words “then-applicable specified amount of 6-day Ci per week”.

2.3    Section 2.3 of the Original Agreement is hereby amended by deleting from the first sentence thereof the words “regular 400 6-day Ci per week” and replacing therewith the words “then-applicable specified amount of 6-day Ci per week”.

		
	2.4
	Section 5.1 of the Original Agreement is hereby amended by deleting in its entirety said Section 5.1 and replacing therewith the following:

		
	5.1
	The price payable by Lantheus for Product for the period from January 1 through July 31, 2010 shall be as follows:

In exchange for the commitment of Lantheus to purchase the amounts set forth in Section 2.1 in any given week (subject to NTP’s ability to supply such amounts in such weeks), the unit price of Product for such week shall be three hundred seventy-five fixed US dollars (US$375) per Curie at calibrated date and time for the first four hundred (400) Curies delivered per week and five hundred sixty-five fixed US dollars (US$565) per Curie at calibrated date and time for all Curies in excess of the first four hundred (400) Curies delivered per week.  The calibration date and time shall be in accordance with Section 2.4.  Such price will be adjusted annually upon mutual agreement of the parties as of each subsequent August 1 of the Agreement on the basis of market forces prevailing at the time, the then current cost of production and any contractual sales obligations that Lantheus may have with its customers and by negotiation and agreement by, at the 

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latest, the last day of May preceding the commencement of the new pricing term (1 August of each year that the contract is in place).  Lantheus shall have the right to terminate the Agreement if the parties fail to agree on new pricing by such last day of May.  Changes in contracted volumes not required during the course of a contractual period, i.e., 1 August to 31 July of the following year, the latter of which would be handled by the terms of Section 2.1 or 2.2, but applicable for the ensuing contractual period, shall be agreed at the same time as the annual negotiations on product prices as outlined in this Section 5.1 above.

NTP shall invoice Lantheus at the end of each month for all Product supplied by NTP or its Subcontractor in that month.  Invoicing shall be in respect of the price applicable to Product upon delivery of such conforming Product to Lantheus on an FCA basis, and in respect of container charges as the same become payable under this Agreement.  Lantheus shall pay all invoices for shipments of conforming Product in any given month (as reduced by any outstanding credits for nonconforming Product) by the end of the following month to NTP.  

3.    Waiver.  Each party hereby waives any non-compliance with the terms and provisions of the Original Agreement as in effect immediately prior to the amendment thereof by this Agreement.

4.    General.  Except as specifically amended hereby, the Original Agreement remains in full force and effect and otherwise unamended hereby.  This Amendment constitutes a final written expression of the terms hereof and is a complete and exclusive statement of those terms.  This Amendment shall be governed by and construed in accordance with the laws of England, without reference to its choice of laws rules.

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IN WITNESS WHEREOF, the parties hereto have duly executed this Amendment as of the date first written above.

For and on behalf of NTP:
                    	
	
	/s/ [Illegible]

	Name and Title: Marketing & Sales Manager, 15 March 2010

For and on behalf of Lantheus:
                    	
	
	/s/ William C. Dawes, Jr.

	Name and Title: William C. Dawes, Jr., VP Mfg & Supply Chain

Witnessed by IRE:
                    	
	
	/s/ Jean-Michel Vanderhofstadt

	Name and Title: Jean-Michel Vanderhofstadt, Director General

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