Document:

Asset Purchase Agreement

     This Asset Purchase Agreement (the "Agreement") is made and effective
January 25, 2000, by and between CraftClick.com, Inc., An Utah Corporation
("Buyer") and Kirk A. Hines ("Seller").

     Seller operates a search web site specific to the online crafts
community under the names Bella-decor.com, Craftssearch.com, and Craft-search-
engine.com  (the "Business").

     Seller desires to sell to Buyer, and Buyer desires to purchase from
Seller, certain assets of Seller used in the Business, subject to the terms of
this Agreement.

     NOW, THEREFORE, the parties agree as follows:

1.   Transfer of Assets.  At the Closing, subject to the terms of this
Agreement, Seller shall sell, assign, transfer, convey and deliver to Buyer,
and Buyer shall purchase from Seller, free and clear of all liens,
encumbrances, claims, clouds, charges, equities or imperfections of any
nature, all software, databases, contract rights, customer lists, trademarks,
trade names, intellectual property, goodwill, materials, supplies, telephone
numbers, business records, and other assets owned by Seller and used or useful
in the Business and related operations.  The assets and properties to be
transferred by Seller to Buyer shall include, without limitation those
identified in Exhibit A attached hereto.

  2. Conveyance and Transfer Documents.  Seller agrees to deliver to Buyer at
the Closing such certificates, bills of sale, documents of title and other
instruments of conveyance and transfer, in form and content satisfactory to
Buyer, as shall be effective to vest in Buyer good and marketable title in and
to any property to be sold, assigned, transferred, conveyed and delivered
hereunder.

3.   Payment of Purchase Price.  In exchange for full payment for all of the
items purchased from Seller, Buyer shall issue Seller 100,000 shares of its
common stock. Such issued shares shall be "restricted securities" and shall be
imprinted with the following legend or a reasonable facsimilie thereof on the
front and reverse sides thereof:

The shares of stock represented by this certificate have not been registered
under the Securities Act of 1933, as amended, and may not be sold or otherwise
transferred unless compliance with the registration provisions of such Act has
been made or unless availability of an exemption from such registration
provisions has been established, or unless sold pursuant to Rule 144 under the
Act.

4.   Nonassumption of Liabilities.  Except as otherwise agreed expressly in
writing, Buyer does not and shall not assume or agree to pay any of Seller's
or, where applicable, any shareholder's, partner's, or member's, liabilities
or obligations of any nature or kind.  Seller and, where applicable, any
shareholder, partner, or member, shall each remain responsible for their
respective debts and obligations.

5.   Further Assurances.  From time to time after the date of this Agreement,
Seller shall give to Buyer, and to Buyer's representatives, auditors and
counsel, full access during normal business hours to all of the properties,
books, records, tax returns, contracts, licenses, franchises and all of the
documents of Seller relating to the Business and shall furnish to Buyer all
information with respect to the Business, as Buyer may from time to time
reasonably request.  Promptly following execution of this Agreement, Seller
shall use Seller's best efforts to obtain all consents (if any, including,
without limitation, consents of any government or governmental agency)
necessary to effect the sale, assignment, transfer, conveyance and delivery
contemplated by Section 1 hereof.  From time to time after the Closing, at
Buyer's request and without further consideration, Seller agrees to execute
and deliver at Seller's expense such other instruments of conveyance and
transfer and take such other action as Buyer reasonably may require more
effectively to sell, assign, transfer, convey, deliver and vest in Buyer, and
to put Buyer in possession of, any property to be sold, assigned, transferred,
conveyed and delivered hereunder.

6.   Closing.
     A.   The issuance of shares, delivery of documents and completion of
other
items related to the transfer of the Business and the assets purchased by
Buyer (the "Closing") shall be held on January 25, 2000, at 5:00 p.m., at
Columbia, SC, or on such other date, and at such other time and place, as
mutually agreed upon by the parties in writing.
     B.   At the Closing:
       (i)  Seller shall execute and deliver to Buyer the instruments of
conveyance and transfer called for in Section 2 hereof;
       (ii) Buyer shall deliver to Seller a Board resolution instructing
the Buyer's transfer agent to issue the stock called for in Section 3 above.
     C.   In the event that the Closing hereunder shall not be consummated by
January 31, 2000 for any reason other than some act, omission or  material
breach by Buyer, this Agreement shall, at the sole option of Buyer, terminate.

7.   Representations and Warranties of Seller.  Seller represents and warrants
to and covenants with Buyer, and Buyer's successors and assigns (which
representations, warranties and covenants shall survive the Closing), as
follows:
     A.   Seller has full power and authority to execute and deliver the
Agreement and to consummate the transactions contemplated hereby.
     B.   This Agreement and Seller's performance of the obligations herein do
not constitute the breach or violation of any agreement, covenant, obligation
or promise to which Seller is legally bound.
     C.   Seller's execution, delivery and performance of this Agreement will
not constitute the breach or violation of any agreement, obligation, promise,
covenant or court order with respect to any spousal maintenance or child
support obligation and that Seller's spouse, if any, does not own any part of
the Business and no consent or waiver by any such spouse is required to
complete Seller's obligations herein.
     D.   Except as otherwise disclosed by Seller in writing, as of the date
of
this Agreement, the assets and properties of Seller are not, and as of the
Closing they will not be, subject to any liens, encumbrances, claims, clouds,
charges, equities or imperfections of any nature.
     E.   Neither the execution or delivery by Seller of this Agreement or the
transactions contemplated hereby will: (i) result in the creation of any lien,
security interest, or encumbrance upon any of the assets of Seller; (ii)
violate any order, writ, injunction, decree, judgment, law, rule, regulation
or ruling of any court or governmental authority applicable to Seller or any
of its properties; or (iii) require any consent, approval or authorization of,
or declaration, filing or registration with, any governmental or regulatory
authority.
     F.   Seller, and where applicable any shareholder, officer, director,
member or partner, are in violation of, or under investigation with respect
to, or have been charged with or given notice of, any violation of any
applicable law, statute, order, rule, regulation, policy or guideline
promulgated or judgment entered, by any federal, state or local court or
governmental authority relating to or affecting the Business, Seller or any of
Seller's assets.
     G.   As of the Closing Date there has not been, any materially adverse
change in the financial condition, assets, liabilities, business or property
of Seller, or with respect to its employees or customers, and Seller has no
knowledge of any fact or contemplated event which may, in the future, cause
any such materially adverse change.  As of the date of Closing, the business
of the Seller has been, and will be, conducted only in the ordinary course.
     H.   Copies of all  instruments, agreements and other documents which
have
been delivered or may be delivered to Buyer by Seller pursuant to or in
connection with this Agreement are and will be complete and correct as of the
date hereof and as of the Closing.  Exhibits B and C, attached hereto and made
a part hereof, are lists of all contracts, leases, licenses and other
agreements relating to the Business.  Seller is not in default and has not
received any notice of default under any such contract, lease, license or
other agreement or under any other obligation relating to the Business.
     I.   As of the date hereof there is, and on the Closing Date there will
be, no litigation at law or in equity, no proceeding before any commission or
other administrative or regulatory authority, and no dispute, claim or
controversy (including, without limitation, labor union strikes, elections,
arbitrations, grievances, complaints, or administrative actions) pending, or
to the knowledge of Seller threatened, against or affecting the business or
property of Seller or it right to carry on it business and enter into and
consummate the transactions contemplated by this Agreement.
     J.   There is no unfair labor practice complaint against Seller pending
before the National Labor Relations Board.  There is no labor strike dispute,
slowdown or stoppage, or any union organizing campaign, pending, or to the
best of the knowledge of Seller, threatened against or involving Seller.  No
labor agreements have been filed with Seller which has had, or may have, a
materially adverse effect on Seller's business.  No collective bargaining
agreement is currently being negotiated with Seller.
     K.   Seller has not employed any broker or finder or incurred any
liability for any brokerage fees, commissions, finder fees or similar fees or
expenses, and no broker or finder has acted directly or indirectly for Seller
in connection with this Agreement or the transactions contemplated hereby.
     L.   On the date hereof Seller has, and on the Closing Seller shall have,
duly prepared and timely filed all local, state and federal tax returns
(including, without limitation, those which relate to FICA, withholding and
other payroll taxes) required to be filed by such dates, and paid all taxes,
penalties and interest with respect thereto.  To the extent that any tax
liabilities have accrued but not become payable, the full amounts thereof have
been reflected as liabilities or reserved against on the Balance Sheet.  After
the Closing, Seller shall duly prepare and timely file any and all local,
state and federal tax returns which pertain, in whole or in part, to the
period on or before the Closing, and pay all taxes, penalties and interest
with respect thereto.
     M.   On the date hereof, the properties and assets to be transferred
under
this Agreement are, and on the Closing they will be, in good condition and
repair.
     N.   Seller shall permit Buyer and its representatives at all reasonable
times during business hours and without interfering with the normal conduct of
the business of Seller, to examine and have full access to all of the
properties, books and records of Seller and to copy such books and records (at
Buyer's expense).

8.   Representations and Warranties of Buyer.  Buyer represents and warrants
to
and covenants with Seller (which representations and warranties shall survive
the Closing) as follows:
     A.   Buyer is a Corporation duly organized, validly existing and in good
standing under the laws of the State of Utah.
     B.  Buyer has full power and authority to execute and deliver the
Agreement and to consummate the transactions contemplated hereby.  The
execution, delivery and consummation of this Agreement have been duly
authorized and approved by such directors of Buyer as required by, and in
accordance with, applicable laws and the instruments, agreements and documents
controlling Buyer's governance.
     C.   As of the date hereof there is, and as of the Closing there will not
be litigation at law or in equity, no proceeding before any commission or
other administrative or regulatory authority, and no dispute, claim or
controversy pending, or to the knowledge of Buyer threatened, against or
affecting the right of Buyer to enter into and consummate the transactions
contemplated by this Agreement.
  D.  Buyer has not employed any broker or finder or incurred any
liability for any brokerage fees, commissions, finder fees or similar fees or
expenses in connection with the transactions contemplated by this Agreement,
and no broker or finder has acted on Buyer's behalf.

9.   Indemnification.
     A.   Seller indemnifies and holds harmless Buyer against any loss, damage
or expense (including, without limitation, taxes, penalties, interest and
reasonable attorney's fees) asserted against or suffered by Buyer arising out
of or resulting from (i) any breach of this Agreement by Seller; (ii) any
inaccuracy in the representations, warranties, and covenants made by Seller in
this Agreement, or in any certificate, schedule, exhibit or written instrument
delivered or to be delivered under this Agreement; and (iii) any liability,
obligation, demand, claim, action, or judgment, known or unknown, which may
already have arisen or which may hereafter arise, by reason of or in
connection with the operation of Seller's business prior to the Closing.
     B.   (i) Buyer shall promptly notify Seller of any claim or demand which
Buyer determines has given or could give rise to a right of indemnification
under this Agreement.  Unless Seller give Buyer written notice that either
contests Buyer's right to indemnification for a claim or demand within thirty
(30) days of the date Buyer notifies them of such a claim or demand, Seller
shall be deemed to have acknowledged Buyer's right to indemnification for such
claim or demand pursuant to the provisions of this Agreement.
  (ii) If any claim or demand relates to a claim or demand asserted by
a third party against Buyer, Seller shall have the duty, at Seller's expense,
to defend any such claim or demand.  Buyer shall make available to Seller and
Seller's representatives all records and other materials reasonably required
by them for their use in contesting any such claim or demand.  Buyer shall
have the right, but not the obligation, to employ separate counsel, and to
participate with Seller in the defense of any such claim or demand, but the
fees and expenses of such separate counsel shall be paid by Buyer.  In not
event shall Buyer be obligated to defend any such claim or demand.

10.  Conditions Precedent to the Obligations of Buyer.  The obligations of
Buyer under this Agreement are subject to the following conditions precedent:
     A.   The representations, warranties and covenants made by Seller herein
to Buyer shall be true and correct in all material respects on and as of the
Closing Date with the same effect as if such representations, warranties and
covenants had been made on and as of date of the Closing, and Seller shall
have performed and complied with all agreements, covenants and conditions on
their part required to be performed and complied with on or prior to the
Closing.
     B.   The assets to be purchased by Buyer and the Business shall not have
been adversely affected in any material way (whether or not covered by
insurance) as a result of any fire, casualty, act of God or other force
majeure or any labor dispute or disturbances.

11.  Conditions Precedent to the Obligations of Seller.  The obligations of
Seller shall be subject to the condition precedent that all warranties,
representations, and covenants made by Buyer to Seller in this Agreement shall
be true and correct in all material respects on and as of the Closing with the
same effect as if such warranties, representations, and covenants had been
made on and as of the date of the Closing, and Buyer shall have performed or
complied with all agreements, covenants and conditions on its part required to
be performed or complied with on or prior to the Closing.

12.  Covenants of Seller.  Seller covenants with Buyer as follows:
          During the two year period from and after the Closing, Seller shall
not directly or indirectly,  or as a partner, shareholder, employee, manager
or otherwise, own, manage, operate, control, be employed by, participate in,
or otherwise be connected with any other business the same as or similar to
the Business.  In the event any of the provisions of this Section shall be
determined to be invalid by reason of their scope or duration, this Section
shall be deemed modified to such extent as required to cure the invalidity.
In the event of a breach, or a threatened breach, of this covenant, Buyer
shall be entitled to obtain an injunction restraining the commencement or
continuance or the breach, as well as to any other legal or equitable remedies
permitted by law.

13.  Consulting Agreement.  At the Closing, Buyer and Seller (or a principal
of Seller) shall enter into a Consulting Agreement in the form and with the
content of the Consulting Agreement attach as Exhibit B.

14.  Notices.
Any notice under this Agreement shall be effectively given upon deposit in the
United States mail, postage prepaid, or by recognized overnight delivery
service, and addressed as follows (or at such change of address given by one
party to the other in writing after the date hereof):
  If to Buyer:  CraftClick.com, Inc., 432 Culver Blvd., Playa Del Rey, CA
  90293

  If to Seller:  Kirk A. Hines, 104 Stonewall Street, Raeford, NC 28376

15.  Final Agreement.
This Agreement represents the full agreement between the parties and
supersedes any and all prior negotiations and understandings between them.
This Agreement may not be modified or amended except by a written instrument
executed by all of the parties.

15.  Governing Law.
This Agreement shall be governed by and construed according to the laws of the
State of Utah.

16.  Force Majeure.
Nonperformance of either party shall be excused to the extent that performance
is rendered impossible by strike, fire, flood, governmental acts, orders or
restrictions, or any other reason where failure to perform is beyond the
control and not caused by the negligence of the non-conforming party.

17.  No Assignment.
The parties agree that neither party may assign or transfer any rights and
obligations under this Agreement, directly or indirectly except upon the prior
written consent of the other party.  Subject to the foregoing, this Agreement
shall be binding upon and inure to the benefit of the parties hereto, their
successors and assigns.

18.  Severability.
If any provision of this Agreement is held to be invalid by a court of
competent jurisdiction, then the remaining provisions shall nevertheless
remain in full force and effect.

19.  Counterparts.
This Agreement may be executed in two or more counterparts, each of which
shall be deemed an original.

20.  Headings.
Headings used in this Agreement are provided for convenience only and shall
not be used to construe meaning or intent.

  IN WITNESS WHEREOF, the parties hereto have executed this Agreement on
the day and year first above written.

CraftClick.com, Inc.

By:/S/Peter A. Yollin           /s/Kirk A. Hines
Peter A. Yollin                 Kirk A. Hines
Chief Executive Officer
<PAGE>
                           EXHIBIT A
                        Seller's Assets

All software relating to the Business, including but not limited to operating
and application software.

All domain names registered to the Business, including but not limited to
Bella-decor.com, Craftssearch.com and Craft-search-engine.com.

All e-mail lists and registered member information (approximately 5,000 e-mail
addresses).

Complete access including passwords to the Business web site.

Any information that is stored in the databases of the Business.
<PAGE>
                           EXHIBIT B
                      Consulting Agreement

                INDEPENDENT CONTRACTOR AGREEMENT

This Independent Contractor Agreement ("Agreement") is made and effective this
January 25, 2000, by and between Kirk A. Hines ("Consultant") and
CraftClick.com, Inc., An Utah Corporation ("Company").

Now, therefore, Consultant and Company agree as follows:

1.  Engagement.
Company hereby engages Consultant, and Consultant accepts engagement, to
provide to Company the following services:

Maintenance and upkeep of the bella-decor.com web site.

2.  Term.
Consultant shall provide services to Company pursuant to this Agreement for a
term commencing on January 25, 2000 and ending on January 25, 2001.

3.  Place of Work.
Consultant shall render services primarily at Consultant's offices, but will,
upon request, provide the services at Company offices or such other places as
reasonably requested by Company as appropriate for the performance of
particular services.

4.  Time.
Consultant's daily schedule and hours worked under this Agreement on a given
day shall generally be subject to Consultant's discretion, provided that
Consultant and Company anticipate that Consultant shall work on average 10
(ten) hours per week in the performance of services pursuant to this
Agreement.  Company relies upon Consultant to devote sufficient time as is
reasonably necessary to fulfill the spirit and purpose of this Agreement.

5.  Payment.
Company shall pay Consultant $1,000 per month for services performed pursuant
to this Agreement.  Payment shall be made monthly.  Consultant shall bear all
of Consultant's expenses incurred in the performance of this Agreement.

6.  Covenant Not to Compete.
During the term of this Agreement and for a period of two years thereafter,
Consultant shall not directly or indirectly, either for his own account, or as
a partner, shareholder, officer, director, employee, agent or otherwise; own,
manage, operate, control, be employed by, participate in, consult with,
perform services for, or otherwise be connected with any business the same as
or similar to the business conducted by Company.  In the event any of the
provisions of this Section 6 are determined to be invalid by reason of their
scope or duration, this Section 6 shall be deemed modified to the extent
required to cure the invalidity.  In the event of a breach, or a threatened
breach, of this Section 6, Company shall be entitled to obtain an injunction
restraining the commitments or continuance of the breach, as well as any other
legal or equitable remedies permitted by law.

7.  Confidentiality.
During the term of this Agreement, and thereafter for a period of two (2)
years, Consultant shall not, without the prior written consent of Company,
disclose to anyone any Confidential Information.  "Confidential Information"
for the purposes of this Agreement shall include Company's proprietary and
confidential information such as, but not limited to, customer lists, business
plans, marketing plans, financial information, designs, drawing,
specifications, models, software, source codes and object codes.  Confidential
Information shall not include any information that:

  A.  is disclosed by Company without restriction;

  B.  becomes publicly available through no act of Consultant;

  C.  is rightfully received by Consultant from a third party.

8.  Termination.
A.  This Agreement may be terminated by Company as follows:

  i. If Consultant is unable to provide the consulting services by reason of
     temporary or permanent illness, disability, incapacity or death.

  ii.  Breach or default of any obligation of Consultant pursuant to
     Section 6, Covenant Not to Compete, or Section 7, Confidentiality, of
     this Agreement.

  iii. Breach or default by Consultant of any other material obligation
     in this Agreement, which breach or default is not cured within five (5)
     days of written notice from Company.

B.  Consultant may terminate this Agreement as follows:
  i. Breach or default of any material obligation of Company, which breach or
     default is not cured within five (5) days of written notice from
     Consultant.

  ii.  If Company files protection under the federal bankruptcy laws, or
     any bankruptcy petition or petition for receiver is commenced by a third
     party against Company, any of the foregoing of which remains undismissed
     for a period of sixty (60) days.

9.  Independent Contractor.
Consultant is and throughout this Agreement shall be an independent contractor
and not an employee, partner or agent of Company.  Consultant shall not be
entitled to nor receive any benefit normally provided to Company's employees
such as, but not limited to, vacation payment, retirement, health care or sick
pay.  Company shall not be responsible for withholding income or other taxes
from the payments made to Consultant.  Consultant shall be solely responsible
for filing all returns and paying any income, social security or other tax
levied upon or determined with respect to the payments made to Consultant
pursuant to this Agreement.

10.  Tools and Supplies.
Unless otherwise agreed to by Company in advance, Consultant shall be solely
responsible for procuring, paying for and maintaining any computer equipment,
software, paper, tools or supplies necessary or appropriate for the
performance of Consultant's services hereunder.

11.  Controlling Law.
This Agreement shall be governed by and construed in accordance with the laws
of the State of Utah.

12.  Headings.
The headings in this Agreement are inserted for convenience only and shall not
be used to define, limit or describe the scope of this Agreement or any of the
obligations herein.

13.  Final Agreement.
This Agreement constitutes the final understanding and agreement between the
parties with respect to the subject matter hereof and supersedes all prior
negotiations, understandings and agreements between the parties, whether
written or oral.  This Agreement may be amended, supplemented or changed only
by an agreement in writing signed by both of the parties.

14.  Notices.
Any notice required to be given or otherwise given pursuant to this Agreement
shall be in writing and shall be hand delivered, mailed by certified mail,
return receipt requested or sent by recognized overnight courier service as
follows:

  If to Consultant:
  Kirk A. Hines
  104 Stonewall Street
  Raeford, NC 28376

  If to Company:
  CraftClick.com, Inc.
  432 Culver Blvd.
  Playa Del Rey, CA 90293

15.  Severability.
If any term of this Agreement is held by a court of competent jurisdiction to
be invalid or unenforceable, then this Agreement, including all of the
remaining terms, will remain in full force and effect as if such invalid or
unenforceable term had never been included.

IN WITNESS WHEREOF, this Agreement has been executed by the parties as of the
date first above written.

  CraftClick.com, Inc.

/S/Kirk A. Hines                By:/s/Peter A. Yollin
Kirk A. Hines                   Peter A. Yollin
  Chief Executive Officer

<PAGE>
Interwest Transfer Co.
1981 East Murray-Holladay Rd.
P. O. Box 17136
Salt Lake City, Utah  84117

Craftclick.com, Inc.
432 Culver Blvd.
Playa Del Rey, California 90393

Re:       Exchange of shares of Bella-decor.com, ("Bella") in exchange
          for shares of Craftclick.com, Inc., a Utah corporation ("Craftclick
          or "the Company")

Dear Ladies and Gentlemen:

          Pursuant to that certain Agreement and Plan of Reorganization (the
"Agreement") between the undersigned, I acknowledge that I have approved this
exchange; that I am aware of all of the terms and conditions of the Agreement;
that I have received and personally reviewed a copy of any and all material
documents regarding the Company, including, but not limited to Articles of
Incorporation, Bylaws, minutes of meetings of directors and stockholders,
financial statements and the Company's Annual and Quarterly and Current
Reports filed with the Securities and Exchange Commission for the past twelve
months which can be reviewed in the Edgar Archives at www.sec.gov.  I
represent and warrant that no director or officer of the Company or any
associate of either has solicited this exchange; that I am an "accredited
investor" as that term is known under the Rules and Regulations of the
Securities and Exchange Commission; and/or, I represent and warrant that I
have sufficient knowledge and experience to understand the nature of the
exchange and am fully capable of bearing the economic risk of the loss of my
entire cost basis.  I hereby compromise and waive any claims I have or may
have against Bella under any federal or state securities laws, rules or
regulations or otherwise, or for any other reason whatsoever.

          I understand that you have and will make books and records of your
Company available to me for my inspection in connection with the contemplated
exchange of my shares, and that I have been encouraged to review the
information and ask any questions I may have concerning the information of any
director or officer of the Company or of the legal and accounting firms for
the Company.  I understand that the accounting firm for Craftclick is Mantyla,
McReynolds & Assoc., 5872 South 900 East, #250, Salt Lake City, Utah 84121;
Telephone: (801) 269-1818; and that legal counsel for Craftclick is Leonard W.
Burningham, Esq., 455 East 5th South, Suite 205, Salt Lake City, Utah 84111,
Telephone #801-363-7411.

          I also understand that I must bear the economic risk of ownership
of any of the Craftclick shares for a long period of time, the minimum of
which will be one (1) year, as these shares are "unregistered" shares and may
not be sold unless any subsequent offer or sale is registered with the United
States Securities and Exchange Commission or otherwise exempt from the
registration requirements of the Securities Act of 1933, as amended (the
"Act"), or other applicable laws, rules and regulations.

          I intend that you rely on all of my representations made herein
and those in the personal questionnaire (if applicable) I provided for use by
Craftclick as they are made to induce you to issue me the shares of
Craftclick under the Agreement, and I further represent (of my personal
knowledge or by virtue of my reliance on one or more personal
representatives), and agree as follows, to-wit:

          1.   That the shares being acquired are being received for
investment purposes and not with a view toward further distribution;

          2.   That I have a full and complete understanding of the phrase
"for investment purposes and not with a view toward further distribution";

          3.   That I understand the meaning of "unregistered shares" and
know that they are not freely tradeable;

          4.   That any stock certificate issued by you to me in connection
with the shares being acquired shall be imprinted with a legend restricting
the sale, assignment, hypothecation or other disposition unless it can be made
in accordance with applicable laws, rules and regulations;

          5.   I agree that the stock transfer records of your Company
shall reflect that I have requested the Company not to effect any transfer of
any stock certificate representing any of the shares being acquired unless I
shall first have obtained an opinion of legal counsel to the effect that the
shares may be sold in accordance with applicable laws, rules and regulations,
and I understand that any opinion must be from legal counsel satisfactory to
the Company and, regardless of any opinion, I understand that the exemption
covered by any opinion must in fact be applicable to the shares;

          6.   That I shall not sell, offer to sell, transfer, assign,
hypothecate or make any other disposition of any interest in the shares being
acquired except as may be pursuant to any applicable laws, rules and
regulations;

          7.   I fully understand that my shares which are being exchanged
for shares of the Company are "risk capital," and I am fully capable of
bearing the economic risks attendant to this investment, without
qualification; and

          8.   I also understand that without approval of counsel for
Craftclick, all shares of Craftclick to be issued and delivered to me shall be
represented by one stock certificate only and which such stock certificate
shall be imprinted with the following legend or a reasonable facsimile thereof
on the front and reverse sides thereof:

          The shares of stock represented by this certificate
          have not been registered under the Securities Act of
          1933, as amended, and may not be sold or otherwise
          transferred unless compliance with the registration
          provisions of such Act has been made or unless
          availability of an exemption from such registration
          provisions has been established, or unless sold
          pursuant to Rule 144 under the Act.

          Any request for more than one stock certificate must be
accompanied by a letter signed by the requesting stockholder setting forth all
relevant facts relating to the request.  Craftclick will attempt to
accommodate any stockholders' request where Craftclick views the request is
made for valid business or personal reasons so long as in the sole discretion
of Craftclick, the granting of the request will not facilitate a "public"
distribution of unregistered shares of common voting stock of Craftclick.

          You are requested and instructed to issue a stock certificate as
follows, to-wit:

          Kirk A. Hines   100,000
          (Name(s) and Number of Shares)

          104 Stonewall Street
          (Address)

          Racford, NC 28376
          (City, State and Zip Code)

          If joint tenancy with full rights of survivorship is
          desired, put the initials JTRS after your names.

          Dated this 26th day of January, 2000.

                              Very truly yours,

                              /s/Kirk A. Hines<PAGE>

                                                                    Exhibit 4.2

                          FOURTH AMENDED AND RESTATED
                         REGISTRATION RIGHTS AGREEMENT

     This Fourth Amended and Restated Registration Rights Agreement (the
"Agreement"), which amends and restates that certain Third Amended and Restated
Registration Rights Agreement, dated as of August 21, 1998 (the "Prior
Agreement"), is entered into as of February 26, 1999, by and among Exelixis
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), the investors
listed on Exhibit A hereto (the "Series A Investors"), the investors listed on
Exhibit B hereto (the "Series B Investors"), the investors listed on Exhibit C
hereto (the "Series C Investors") and the investors listed on Exhibit D hereto
(the "Series D Investors").

     Whereas, the Company issued and sold (i) 5,328,571 shares of its Series A
Convertible Preferred Stock, $.001 par value, at a purchase price of $.70 per
share ("Series A Preferred Stock") on January 27, 1995 and March 31, 1995 to the
Series A Investors, (ii) 12,300,000 shares of its Series B Convertible Preferred
Stock, $.001 par value, at a purchase price of $1.00 per share ("Series B
Preferred Stock") on March 27, 1996 to the Series B Investors and (iii)
7,875,000 shares of Series C Convertible Preferred Stock, $.001 par value, at a
price of $2.00 per share (the "Series C Preferred Stock) on April 8, 1997 and is
issuing up to 5,000,000 shares of Series D Convertible Preferred Stock, $.001
par value at a purchase price of $3.00 per share ("Series D Preferred Stock") to
the Series D Investors, pursuant to the Series D Convertible Preferred Stock
Purchase Agreement dated August 21, 1998 and February 10, 1999(the "Purchase
Agreement") among the Company and the Series D Investors; and

     Whereas, one of the conditions to the consummation of the transactions
contemplated by the Purchase Agreement entered into by the Series D Investors is
the amendment and restatement of the Prior Agreement to provide for registration
rights for the shares of Series D Preferred Stock purchased by the Series D
Investors as set forth herein;

     Whereas, the Company and Pharmacia & Upjohn AB ("P&U") desire to enter into
a stock purchase agreement providing for the issuance and sale by the Company to
P&U of up to 2,500,000 shares of Series D Preferred Stock (the "P&U Purchase
Agreement"); and

     Whereas, this Agreement supersedes and amends and restates the Prior
Agreement in its entirety, and holders of at least 66-2/3 % of the shares of
Restricted Stock (as defined in the Prior Agreement) and the Company hereby
consent and agree to the amendment and restatement of the Prior Agreement and
the Series D Investors in their capacity as purchasers of shares of the Series D
Preferred Stock desire to enter into this Agreement.

     Now, Therefore, in consideration of the mutual covenants and agreements
contained herein and the purchase of the Series D Preferred Stock by the Series
D Investors under the Purchase Agreement, and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereto agree as follows:

                                       1.
<PAGE>

     1.   Certain Definitions.  As used in this Agreement, the following terms
shall have the following respective meanings:

     "Commission" shall mean the Securities and Exchange Commission, or any
other federal agency at the time administering the Securities Act.

     "Common Stock" shall mean the Common Stock, $.001 par value of the Company,
as constituted as of the date of this Agreement.

     "Conversion Shares" shall mean shares of Common Stock issued upon
conversion of the Preferred Stock.

     "Exchange Act" shall mean the Securities Exchange Act of 1934, as amended,
or any similar federal statute, and the rules and regulations of the Commission
thereunder, all as the same shall be in effect at the time.

     "Investors" shall mean the Series A Investors, the Series B Investors, the
Series C Investors and the Series D Investors.  Notwithstanding anything to the
contrary in this Agreement, any purchaser of Series D Preferred Stock under the
Purchase Agreement or the P&U Purchase Agreement, may become a party to this
Agreement by signing a counterpart hereto.  Each such Investor shall be deemed
to be a "Series D Investor" for all purposes under this Agreement.

     "Preferred Stock" shall mean the shares of Series A Preferred Stock, Series
B Preferred Stock, Series C Preferred Stock and Series D Preferred Stock.

     "Restricted Stock" shall mean the Conversion Shares and all other shares of
Common Stock now or hereafter acquired by any of the Investors or any of their
affiliates, but excluding shares of Common Stock which have been (a) registered
under the Securities Act pursuant to an effective registration statement fried
thereunder and disposed of in accordance with the registration statement
coveting them or (b) publicly sold pursuant to Rule 144 under the Securities
Act; provided, however, that the term "Restricted Stock" shall be deemed to
include (i) all shares of any class or series of the capital stock of the
Company and (ii) all securities convertible into or exchangeable for any shares
of any class or series of the capital stock of the Company, in either case held
by any of the Investors or their affiliates.

     "Securities Act" shall mean the Securities Act of 1933, as amended, or any
similar federal statute, and the rules and regulations of the Commission
thereunder, all as the same shall be in effect at the time.

     "Selling Expenses" shall mean the expenses so described in Section 7
hereof.

     2.   Restrictive Legend.  Each certificate representing Preferred Stock or
Conversion Shares shall, except as otherwise provided in Section 3, be stamped
or otherwise imprinted with a legend substantially in the following form:

                                       2.
<PAGE>

     "THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933
     OR APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE TRANSFERRED OR OTHERWISE
     DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT COVERING
     SUCH SHARES UNDER THAT ACT AND ANY APPLICABLE STATE SECURITIES LAWS,
     UNLESS, IN THE OPINION OF COUNSEL SATISFACTORY TO THE COMPANY, AN EXEMPTION
     FROM REGISTRATION THEREUNDER IS AVAILABLE."

     3.   Required Registration.

          (a)  At any time after the earlier of December 31, 1999 or six months
after the effective date of the initial public offering of securities of the
Company pursuant to an effective registration statement under the Securities
Act, the holders of Restricted Stock constituting at least 20% of the total
shares of Restricted Stock then owned beneficially or of record by Investors and
Investor Transferees (as such term is hereinafter defined) may require the
Company to register under the Securities Act all or any portion of the shares of
Restricted Stock held by such requesting holder or holders for sale in the
manner specified in such notice, provided that the reasonably anticipated
aggregate price to the public of such public offering would exceed $5,000,000.
Notwithstanding the foregoing, the only securities that the Company shall be
required to register pursuant hereto shall be shares of Common Stock; provided,
however, that in any underwritten public offering contemplated by this
Agreement, the holders of Preferred Stock shall be entitled to sell such
Preferred Stock to the underwriters for conversion and sale of the shares of
Common Stock issued upon conversion thereof. Notwithstanding anything to the
contrary contained herein, the Company shall not be required to cause a
registration pursuant to this Subsection 3(a) to become effective prior to the
date which is 180 days after the effective date of a registration statement
filed by the Company covering a firm commitment underwritten public offering of
securities of the Company under the Securities Act.

          (b)  Following receipt of any notice under this Section 3, the Company
shall immediately notify all Investors and Investor Transferees from whom notice
has not been received and shall use its best efforts to register under the
Securities Act, for public sale in accordance with the method of disposition
specified in such notice from requesting holders, the number of shares of
Restricted Stock specified in such notice (and in all notices received by the
Company from other holders within 30 days after the giving of such notice by the
Company). If such method of disposition shall be an underwritten public
offering, the holders of a majority of the shares of Restricted Stock to be sold
in such offering may designate the managing underwriter of such offering,
subject to the approval of the Company, which approval shall not be unreasonably
withheld or delayed. The Company shall be obligated to register Restricted Stock
pursuant to this Section 3 on two occasions only; provided, however, that such
obligation shall be deemed satisfied only when a registration statement covering
all shares of Restricted Stock specified in notices received as aforesaid, for
sale in accordance with the method of disposition specified by the requesting
holders, shall have become effective and, if such method of disposition is a
firm commitment underwritten public offering, all such shares shall have been
sold pursuant thereto.

                                       3.
<PAGE>

          (c)  In the event that any registration statement pursuant to this
Section 3 shall be, in whole or in part, an underwritten public offering of
Common Stock, the number of shares of Restricted Stock to be included in such an
underwriting may be reduced (pro rata among the requesting holders based upon
the number of shares of Restricted Stock owned by such holders) if and to the
extent that the managing underwriter shall be of the opinion (and shall provide
a written opinion) that the inclusion of some of the Restricted Stock would
adversely affect the marketing of the securities to be sold therein; provided,
however, that (1) no shares of Restricted Stock which are not then subject to
volume restrictions under Rule 144 under the Securities Act and (2) no shares of
Common Stock to be sold by the Company for its own account, shall be included in
such public offering unless all the shares of Restricted Stock requested to be
included in such public offering which (i) are held by holders who are not
affiliates of the Company and (ii) are subject to such restrictions, are
included in such public offering.

          (d)  Subject to Subsection 3(c), the Company shall be entitled to
include in any registration statement referred to in this Section 3, for sale in
accordance with the method of disposition specified by the requesting holders,
shares of Common Stock to be sold by the Company for its own account, except as
and to the extent that, in the reasonable opinion of the managing underwriter
(if such method of disposition shall be an underwritten public offering), such
inclusion would materially adversely affect the marketing of the Restricted
Stock to be sold.

Except for registration statements on Form S-4, S-8 or any successor thereto,
the Company will not file with the Commission any other registration statement
with respect to its Common Stock, whether for its own account or that of other
stockholders, from the date of receipt of a notice from requesting holders
pursuant to this Section 3 until the later of 120 days from the effective date
of the registration statement or completion of the period of distribution of the
shares of Restricted Stock registered thereby.

     4.   Incidental Registration. If the Company at any time (other than
pursuant to Section 3 or Section 5) proposes to register any of its securities
under the Securities Act for sale to the public, whether for its own account or
for the account of other security holders or both (except with respect to
registration statements on Forms S-4, S-8 or another form not available for
registering the Restricted Stock for sale to the public), each such time it will
give written notice to all holders of outstanding Restricted Stock of its
intention so to do and of the proposed method of distribution of such
securities. Upon the written request of any such holder, received by the Company
within 30 clays after the giving of any such notice by the Company, to register
any of its Restricted Stock, the Company will use its best efforts to cause the
Restricted Stock as to which registration shall have been so requested to be
included in the securities to be covered by the registration statement proposed
to be filed by the Company, all to the extent and under the conditions such
registration is permitted under the Securities Act. In the event that any
registration pursuant to this Section 4 shall be, in whole or in part, an
underwritten public offering of Common Stock, the number of shares of Restricted
Stock to be included in such an underwriting may be reduced (pro rata among the
requesting holders based upon the number of shares of Restricted Stock owned by
such holders) if and to the extent that the managing underwriter shall be of the
opinion (and shall provide a written opinion) that the inclusion of some or all
of the Restricted Stock would adversely affect the marketing of the securities
to be sold by the Company therein; provided, however, that such number of shares
of Restricted Stock shall not be reduced if any shares are to be included in
such underwriting for the account of any

                                       4.
<PAGE>

person other than the Company or requesting holders of Restricted Stock.
Notwithstanding the foregoing provisions, the Company may withdraw any
registration statement referred to in this Section 4 without thereby incurring
any liability to the holders of Restricted Stock.

     5.   Registration on Form S-3. If at any time (i) a holder or holders of
Preferred Stock or Restricted Stock holding, in the aggregate, in excess of two
percent (2%) of the then-outstanding Common Stock (including Conversion Shares)
request that the Company file a registration statement on Form S-3 or any
successor thereto for a public offering of all or any portion of the shares of
Restricted Stock held by such requesting holder or holders, the reasonably
anticipated aggregate price to the public (net of underwriting discounts and
commissions) of which would exceed $1,000,000 and (ii) the Company is a
registrant entitled to use Form S-3 or any successor thereto to register such
shares, then the Company shall use its best efforts to register under the
Securities Act on Form S-3 or any successor thereto, for public sale in
accordance with the method of disposition specified in such notice, the number
of shares of Restricted Stock specified in such notice. Whenever the Company is
required by this Section 5 to use its best efforts to effect the registration of
Restricted Stock, each of the procedures and requirements of Section 3
(including but not limited to the requirement that the Company notify all
holders of Restricted Stock from whom notice has not been received and provide
them with the opportunity to participate in the offering) shall apply to such
registration, provided, however, that the requirements contained in the last
sentence of Section 3(a) and in the last sentence of Section 3(b) shall not
apply to any registration on Form S-3 that may be requested and obtained under
this Section 5.

     6.   Registration Procedures. If and whenever the Company is required by
the provisions of Sections 3, 4 or 5 to use its best efforts to effect the
registration of any shares of Restricted Stock under the Securities Act, the
Company will, as expeditiously as possible:

          (a)  Prepare and file with the Commission, within 90 days from the
Company's receipt of notice from the Investors requesting such registration, a
registration statement (which, in the case of an underwritten public offering
pursuant to Section 3, shall be on Form S-1 or other form of general
applicability satisfactory to the managing underwriter selected as therein
provided) with respect to such securities and use its best efforts to cause such
registration statement to become and remain effective for the period of the
distribution contemplated thereby (determined as hereinafter provided);

          (b)  Prepare and file with the Commission such amendments and
supplements to such registration statement and the prospectus used in connection
therewith as may be necessary to keep such registration statement effective for
the period specified in Section 6(a) above and comply with the provisions of the
Securities Act with respect to the disposition of all Restricted Stock covered
by such registration statement in accordance with the sellers' intended method
of disposition set forth in such registration statement for such period;

          (c)  Furnish to each seller of Restricted Stock and to each
underwriter such number of copies of the registration statement and the
prospectus included therein (including each preliminary prospectus) as such
persons reasonably may request in order to facilitate the public sale or other
disposition of the Restricted Stock covered by such registration statement;

                                       5.
<PAGE>

          (d)  Use its best efforts to register or qualify the Restricted Stock
covered by such registration statement under the securities or "blue sky" laws
of such jurisdictions as the sellers of Restricted Stock or, in the case of an
underwritten public offering, the managing underwriter reasonably shall request;
provided, however, that the Company shall not for any such purpose be required
to qualify generally to transact business as a foreign corporation in any
jurisdiction where it is not so qualified or to consent to general service of
process in any such jurisdiction;

          (e)  Use its best efforts to list the Restricted Stock covered by such
registration statement with any securities exchange or quotation system on which
the Common Stock of the Company is then listed;

          (f)  Immediately notify each seller of Restricted Stock and each
underwriter under such registration statement, at any time when a prospectus
relating thereto is required to be delivered under the Securities Act, of the
happening of any event of which the Company has knowledge as a result of which
the prospectus contained in such registration statement, as then in effect,
includes an untrue statement of a material fact or omits to state a material
fact required to be stated therein or necessary to make the statements therein
not misleading in light of the circumstances then existing. The Sellers of
Restricted Stock agree upon receipt of such notice forthwith to cease making
offers and sales of Restricted Stock pursuant to such registration statement or
deliveries of the prospectus contained therein for any purpose until the Company
has prepared and furnished such amendment or supplement to the prospectus as may
be necessary so that, as thereafter delivered to purchasers of such Restricted
Stock, such prospectus shall not include an untrue statement of a material fact
or omit to state a material fact required to be stated therein or necessary to
make the statements therein not misleading in the light of the circumstances
then existing;

          (g)  If the offering is underwritten and at the request of any seller
of Restricted Stock, use its best efforts to furnish on the date that Restricted
Stock is delivered to the underwriters for sale pursuant to such registration
(i) an opinion dated such date of counsel representing the Company for the
purposes of such registration, in form and substance as is customarily given by
Company counsel to the underwriters in an underwritten public offering,
addressed to the underwriters and to such seller, stating, among other things,
that such registration statement has become effective under the Securities Act
and that (A) no stop order suspending the effectiveness thereof has been issued
and no proceedings for that purpose have been instituted or are pending or
contemplated under the Securities Act, (B) the registration statement, the
related prospectus and each amendment or supplement thereof comply as to form in
all material respects with the requirements of the Securities Act (except that
such counsel need not express any opinion as to financial statements and the
notes thereto and the schedules and other financial and statistical data
contained therein) and including a statement that nothing has come to the
attention of such counsel which has caused it to believe that, at the time the
registration statement became effective, the registration statement (other than
the financial statements and the notes thereto and the schedules and other
financial and statistical data contained therein) contained any untrue statement
of a

                                       6.
<PAGE>

material fact or omitted to state a material fact required to be stated therein
or necessary to make the statements therein not misleading, or that the
prospectus (other than the financial statements and the notes thereto and the
schedules and other financial and statistical data contained therein), contained
any untrue statement of a material fact or omitted to state a material fact
required to be stated therein or necessary to make the statements therein, in
light of the circumstances under which they were made, not misleading, and (C)
to such other effects as reasonably may be requested by counsel for the
underwriters or by such seller or its counsel and (ii) a letter dated such date
from the independent public accountants retained by the Company, addressed to
the underwriters and to such seller, stating that they are independent public
accountants within the meaning of the Securities Act and that, in the opinion of
such accountants, the financial statements of the Company included in the
registration statement or the prospectus, or any amendment or supplement
thereof, comply as to form in all material respects with the applicable
accounting requirements of the Securities Act, and such letter shall
additionally cover such other financial matters (including information as to the
period ending no more than five business days prior to the date of such letter)
with respect to such registration as such underwriters reasonably may request;
and

          (h)  Make available for inspection upon reasonable notice during the
Company's regular business hours by each seller of Restricted Stock, any
underwriter participating in any distribution pursuant to such registration
statement, and any attorney, accountant or other agent retained by such seller
or underwriter, all financial and other records, pertinent corporate documents
and properties of the Company, and cause the Company's officers, directors and
employees to supply all information reasonably requested by any such seller,
underwriter, attorney, accountant or agent in connection with such registration
statement.

     For purposes of Section 6(a) and 6(b) and of Section 3(d), the period of
distribution of Restricted Stock in a firm commitment underwritten public
offering shall be deemed to extend until each underwriter has completed the
distribution of all securities purchased by it, and the period of distribution
of Restricted Stock in any other registration shall be deemed to extend until
the earlier of the sale of all Restricted Stock covered thereby and a period of
120 days has elapsed while such distribution is ongoing after the effective date
thereof.

     In connection with each registration hereunder, the sellers of Restricted
Stock shall (a) provide such information and execute such documents as may
reasonably be required in connection with such registration, (b) agree to sell
Restricted Stock on the basis provided in any underwriting arrangements and (c)
complete and execute all questionnaires, powers of attorney, indemnities,
underwriting agreements and other documents required under the terms of such
underwriting arrangements, which arrangements shall not be inconsistent
herewith.

     In connection with each registration pursuant to Sections 3, 4, or 5
covering an underwritten public offering, the Company and each seller agree to
enter into a written agreement with the managing underwriter selected in the
manner herein provided in such form and containing such provisions as are
customary in the securities business for such an arrangement between such
underwriter and companies of the Company's size and investment stature.

     7.   Expenses. All expenses incurred by the Company in complying with
Sections 3, 4, and 5, including, without limitation, all registration and filing
fees, printing expenses, fees and disbursements of counsel and independent
public accountants for the Company, fees and expenses (including counsel fees)
incurred in connection with complying with state securities or "blue sky" laws,
fees of the National Association of Securities Dealers, Inc., transfer taxes,
fees

                                       7.
<PAGE>

of transfer agents and registrars, and fees and disbursements of one counsel for
the sellers of Restricted Stock, but excluding any Selling Expenses, are called
"Registration Expenses." All underwriting discounts and selling commissions
applicable to the sale of Restricted Stock are called "Selling Expenses."

     The Company will pay all Registration Expenses in connection with each
registration statement under Sections 3, 4, or 5.  All Selling Expenses in
connection with each registration statement under Sections 3, 4 or 5 shall be
borne by the participating sellers in proportion to the number of shares sold by
each, or by such participating sellers other than the Company (except to the
extent the Company shall be a seller) as they may agree.

     8.   Indemnification and Contribution.

          (a)  In the event of a registration of any of the Restricted Stock
under the Securities Act pursuant to Sections 3, 4, or 5, the Company will
indemnify and hold harmless each seller of such Restricted Stock thereunder,
each underwriter of such Restricted Stock thereunder and each other person, if
any, who controls such seller or underwriter within the meaning of the
Securities Act, against any losses, claims, damages or liabilities, joint or
several, to which such seller, underwriter or controlling person may become
subject under the Securities Act or otherwise, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based
upon any untrue statement or alleged untrue statement of any material fact
contained in any registration statement under which such Restricted Stock was
registered under the Securities Act pursuant to Sections, 3, 4 or 5, any
preliminary prospectus or final prospectus contained therein, or any amendment
or supplement thereof, or arise out of or are based upon the omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, and will pay the legal
fees and other expenses of each such seller, each such underwriter and each such
controlling person incurred by them in connection with investigating or
defending any such loss, claim, damage, liability or action; provided, however,
that the Company will not be liable in any such case if and to the extent that
any such loss, claim, damage or liability arises out of or is based upon an
untrue statement or alleged untrue statement or omission or alleged omission so
made in reliance upon and in conformity with information furnished by any such
seller, any such underwriter or any such controlling person in writing
specifically for use in such registration statement or prospectus and provided,
further, however, that the Company will not be liable in any such case to the
extent that any such loss, claim, damage, liability or action arises out of or
is based upon an untrue or alleged untrue statement or omission or an alleged
omission made in any preliminary prospectus or final prospectus if (1) such
holder failed to send or deliver a copy of the final prospectus or prospectus
supplement provided by the Company with or prior to the delivery of written
confirmation of the sale of the Restricted Stock, and (2) the final prospectus
or prospectus supplement would have corrected such untrue statement or omission.

          (b) In the event of a registration of any of the Restricted Stock
under the Securities Act pursuant to Section 3, 4 or 5, each seller of such
Restricted Stock thereunder, severally and not jointly, will indemnify and hold
harmless the Company, each person, if any, who controls the Company within the
meaning of the Securities Act, each officer of the Company who signs the
registration statement, each director of the Company, each underwriter and each
person who controls any underwriter within the meaning of the Securities Act,
against

                                       8.
<PAGE>

all losses, claims, damages or liabilities, joint or several, to which the
Company or such officer, director, underwriter or controlling person may become
subject under the Securities Act or otherwise, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based
upon any untrue statement or alleged untrue statement of any material fact
contained in the registration statement under which such Restricted Stock was
registered under the Securities Act pursuant to Sections 3, 4 or 5, any
preliminary prospectus or final prospectus contained therein, or any amendment
or supplement thereof, or arise out of or are based upon the omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, and will pay the legal
fees and other expenses of the Company and each such officer, director,
underwriter and controlling person incurred by them in connection with
investigating or defending any such loss, claim, damage, liability or action;
provided, however, that such seller will be liable hereunder in any such case if
and only to the extent that any such loss, claim damage or liability arises out
of or is based upon an untrue statement or alleged untrue statement or omission
or alleged omission made in reliance upon and in conformity with information
furnished in writing to the Company by such seller specifically for use in such
registration statement or prospectus and provided, further, however, that the
liability of each seller hereunder shall be limited to the proportion of any
such loss, claim, damage, liability or expenses that is equal to the proportion
that the public offering price of the shares sold by such seller under such
registration statement bears to the total public offering price of all
securities sold thereunder, but not in any event to exceed the proceeds received
by such seller from the sale of Restricted Stock covered by such registration
statement,

          (c)  Promptly after receipt by an indemnified party hereunder of
notice of the commencement of any action, such indemnified party shall, if a
claim in respect thereof is to be made against the indemnifying party hereunder,
notify the indemnifying party in writing thereof, but the omission so to notify
the indemnifying party shall not relieve it from any liability that it may have
to such indemnified party other than under this Section 8 and shall only relieve
it from any liability that it may have to such indemnified party under this
Section 8 if and to the extent the indemnifying party is prejudiced by such
omission. In case any such action shall be brought against any indemnified party
and it shall notify the indemnifying party of the commencement thereof, the
indemnifying party shall be entitled to participate in and, to the extent it
shall wish, to assume and undertake the defense thereof with counsel
satisfactory to such indemnified party, and, after notice from the indemnifying
party to such indemnified party of its election so to assume and undertake the
defense thereof, the indemnifying party shall not be liable to such indemnified
party under this Section 8 for any legal expenses subsequently incurred by such
indemnified party in connection with the defense thereof; provided, however,
that, if the defendants in any such action include both the indemnified party
and the indemnifying party and the indemnified party shall have reasonably
concluded (based on the advice of counsel) that there may be reasonable defenses
available to it which are different from or additional to those available to the
indemnifying party or if the interests of the indemnified party reasonably may
be deemed to conflict with the interests of the indemnifying party, the
indemnified party shall have the right to select a separate counsel and to
assume such legal defenses and otherwise to participate in the defense of such
action, with the expenses and fees of such separate counsel and other expenses
related to such participation to be reimbursed by the indemnifying as incurred,
it being understood, however, that the indemnifying party shall not, in
connection with any one such action or separate but substantially similar or
related actions in the same jurisdiction arising out of the same general
allegations or circumstances, be liable for the fees and expenses of more

                                       9.
<PAGE>

than one separate firm of attorneys (together with appropriate local counsel as
required by the local rules of such jurisdiction) at any time for all such
indemnified parties.

          (d)  In order to provide for just and equitable contribution to joint
liability under the Securities Act in any case in which either (i) any holder of
Restricted Stock exercising rights under this Agreement, or any controlling
person of any such holder, makes a claim for indemnification pursuant to this
Section 8 but it is judicially determined Coy the entry of a final judgment or
decree by a court of competent jurisdiction and the expiration of time to appeal
or the denial of the last right of appeal) that such indemnification may not be
enforced in such case notwithstanding the fact that this Section 8 provides for
indemnification in such case, or (ii) contribution under the Securities Act may
be required on the part of any such selling holder or any such controlling
person in circumstances for which indemnification is provided under this Section
8; then, and in each such case, the Company and such holder will contribute to
the aggregate losses, claims, damages or liabilities to which they may be
subject (after contribution from others) in such proportion so that such holder
is responsible for the portion represented by the percentage that the public
offering price of its Restricted Stock offered by the registration statement
bears to the public offering price of all securities offered by such
registration statement, and the Company is responsible for the remaining
portion: provided, however,, that, in any such case, (A) no such holder will be
required to contribute any amount in excess of the public offering price of all
such Restricted Stock offered by it pursuant to such registration statement and
(B) no person or entity guilty of fraudulent misrepresentation (within the
meaning of Section 11(f) of the Securities Act) will be entitled to contribution
from any person or entity who was not guilty of such fraudulent
misrepresentation.

          (e)  No indemnifying party shall, without the prior written consent of
the indemnified party, effect any settlement of any pending or threatened
action, suit or proceeding in respect of which any indemnified party is or could
have been a party and indemnity could have been sought hereunder by such
indemnified party, unless such settlement includes an unconditional release of
such indemnified party from all liability on claims that are the subject matter
of such action, suit or proceeding.

     9.   Changes in Common Stock or Preferred Stock. If, and as often as, there
is any change in the Common Stock or the Preferred Stock by way of a stock
split, stock dividend, combination or reclassification, or through a merger,
consolidation, reorganization or recapitalization, or by any other means,
appropriate adjustment shall be made in the provisions hereof so that the rights
and privileges granted hereby shall continue with respect to the Common Stock or
the Preferred Stock as so changed.

     10.  Rule 144 Reporting and Rule 144A Information. With a view to making
available the benefits of certain rules and regulations of the Commission that
may at any time permit the resale of the Restricted Stock without registration,
the Company will:

          (a)  At all times after 90 days after any registration statement
covering a public offering of securities of the Company under the Securities Act
shall have become effective:

               (i)   Make and keep public information available, as those terms
are understood and defined in Rule 144 under the Securities Act;

                                      10.
<PAGE>

               (ii)  Use its best efforts to file with the Commission in a
timely manner all reports and other documents required of the Company under the
Securities Act and the Exchange Act; and

               (iii) Furnish to each holder of Restricted Stock forthwith upon
request a written statement by the Company as to its compliance with the
reporting requirements of such Rule 144 and of the Securities Act and the
Exchange Act, a copy of the most recent annual or quarterly report of the
Company, and such other reports and documents so filed by the Company as such
holder may reasonably request in availing itself of any role or regulation of
the Commission allowing such holder to sell any Restricted Stock without
registration: and

          (b)  At any time, at the request of any holder of Preferred Stock or
shares of Restricted Stock, make available to such holder and to any prospective
transferee of such Preferred Stock or shares of Restricted Stock the information
concerning the Company described in Rule 144A(d)(4) under the Securities Act.

     11.  Representations and Warranties of the Company. The Company represents
and warrants to the Investors as follows:

          (a)  The execution, delivery and performance of this Agreement by the
Company have been duly authorized by all requisite corporate action and will not
cause a material violation of any provision of any law applicable to the
Company, any order of any court or other agency of government applicable to the
Company, the Charter or By-laws of the Company or any provision of any
indenture, agreement or other instrument to which it or any or its properties or
assets is bound, conflict with, result in a breach of or constitute (with due
notice or lapse of time or both) a default under any such indenture, agreement
or other instrument or result in the creation or imposition of any lien, charge
or encumbrance of any nature whatsoever upon any of the properties or assets of
the Company; and

          (b)  This Agreement has been duly executed and delivered by the
Company and constitutes a legal, valid and binding obligation of the Company,
enforceable in accordance with its terms, subject to laws of general application
from time to time in effect affecting creditors' rights and the exercise of
judicial discretion in accordance with general equitable principles.

     12.  Miscellaneous.

          (a)  All covenants and agreements contained in this Agreement by or on
behalf of any of the parties hereto shall bind and inure to the benefit of the
respective successors and assigns of the parties hereto (including without
limitation transferees of any Preferred Stock or Restricted Stock), whether so
expressed or not; provided, however, that registration rights conferred herein
on the holders of Restricted Stock may not be transferred and registration
rights conferred herein on the Investors shall only inure to the benefit of a
transferee of Preferred Stock or Restricted Stock if (i) there is transferred to
such transferee at least 250,000 shares of Restricted Stock or (ii) such
transferee is a partner or shareholder of an Investor (the transferee in either
such case being referred to as an "Investor Transferee").

                                      11.
<PAGE>

          (b)  All notices, requests, consents and other communications
hereunder shall be in writing, shall be addressed to the receiving party's
address set forth below or to such other address as a party may designate by
notice hereunder, and shall be either (i) delivered by hand, (ii) made by telex,
telecopy or facsimile transmission, (iii) sent by overnight courier, or (iv)
sent by registered or certified mail, return receipt requested, postage prepaid.

               If to the Company, to it at its principal place of business;

               If to any other party hereto, to such party at the address of
               such party as shown on the books of the Company; and

               If to any Investor Transferee, to it at such address as may have
               been furnished to the Company in writing by such Investor
               Transferee;

     All notices, requests, consents and other communications hereunder shall be
deemed to have been given either (i) if by hand, at the time of the delivery
thereof to the receiving party at the address of such party set forth above,
(ii) if made by telex, telecopy or facsimile transmission, at the time that
receipt thereof has been acknowledged by electronic confirmation or otherwise,
(iii) if sent by overnight courier, on the next business day following the day
such notice is delivered to the courier service, or (iv) if sent by registered
or certified mail, on the fifth (5th) business day following the day such
mailing is made.

          (c)  This Agreement shall be governed by and construed in accordance
with the internal law of the state of Delaware without giving effect to the
conflict of law principles thereof.

          (d)  This Agreement may not be amended or modified, and no provision
hereof may be waived, without the written consent of the Company and the holders
of at least sixty-six and two-thirds percent (66-2/3%) of all of the outstanding
shares of Restricted Stock; provided, however, that any amendment which affects
any Series of the Preferred Stock differently from any other Series of the
Preferred Stock must also be approved by holders of at least sixty-six and two-
thirds percent (66-2/3 %) of all of the outstanding shares of such Series of
Preferred Stock. Notwithstanding the foregoing, the Company may, without any
such written consent, amend or modify the Schedule of Investors attached hereto
as Exhibit D to include new Series D Investors.

          (e)  This Agreement may be executed in one or more counterparts, each
of which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

          (f)  If requested in writing by the underwriters for an underwritten
public offering of securities of the Company, each holder of Restricted Stock
who is a party to this Agreement shall agree not to sell publicly any shares of
Restricted Stock or any other shares of Common Stock (other than shares of
Restricted Stock or other shares of Common Stock being registered in such
offering), without the consent of such underwriters, for a period not to exceed
180 days following the effective date of the registration statement relating to
such offering; provided, however, that all persons entitled to registration
rights with respect to shares of Common Stock who are not parties to this
Agreement, all other persons selling shares of Common Stock in such offering and
all executive officers and directors of the Company shall

                                      12.
<PAGE>

also have agreed not to sell publicly their Common Stock under the circumstances
and pursuant to the terms set forth in this Section 12(f) and provided, further,
that the Company shall use reasonable efforts to exclude short selling or other
forms of hedging from the restrictions imposed during such 180 day period.

          (g)  The Company shall not grant to any third party any registration
rights more favorable than, or inconsistent with, any of those contained herein,
so long as any of the registration rights under this Agreement remains in
effect.

          (h)  If any provision of this Agreement shall be held to be illegal,
invalid or unenforceable, such illegality, invalidity or unenforceability shall
attach only to such provision and shall not in any manner affect or render
illegal, invalid or unenforceable any other provision of this Agreement and this
Agreement shall be carded out as if any such illegal, invalid or unenforceable
provision were not contained herein.

          (i)  This Agreement and the rights granted herein shall terminate on
the tenth anniversary of the effective date of the initial public offering of
securities of the Company pursuant to an effective registration statement under
the Securities Act.

          (j)  By execution hereof, the undersigned who were parties to the
Prior Agreement, as the holder of at least 66-2/3 % of all of the outstanding
shares of Restricted Stock (as defined in the Prior Agreement), hereby consent
to and approve of the amendment and restatement of the Prior Agreement as set
forth herein.

          (k)  Limitation of Investors' Liability. The name H&Q Healthcare
Investors is the designation of the Trustees for the time being under an Amended
and Restated Declaration of Trust dated April 21, 1987, as amended, and all
persons dealing with H&Q Healthcare Investors must look solely to the trust
property for the enforcement of any claim against H&Q Healthcare Investors, as
neither the Trustees, officers nor shareholders assume any personal liability
for obligations entered into on behalf of H&Q Healthcare Investors. The name H&Q
Life Sciences Investors is the designation of the Trustees for the time being
under a Declaration of Trust dated February 20, 1992, as amended, and all
persons dealing with H&Q Life Sciences Investors must look solely to the trust
property for the enforcement of any claim against H&Q Life Sciences Investors,
as neither the Trustees, officers nor shareholders assume any personal liability
for obligations entered into on behalf of H&Q Life Sciences Investors.

                                      13.
<PAGE>

     In Witness Whereof, the parties hereto have executed this Agreement as of
the date first written above.

                                    Exelixis Pharmaceuticals, Inc.

                                    By:________________________________

                                    Title:_____________________________

Series A Investor

Name:__________________________

By:____________________________

Title:_________________________

Series B Investor

Name:__________________________

By:____________________________

Title:_________________________

Series C Investor

Name:__________________________

By:____________________________

Title:_________________________

Series D Investor

Name:__________________________

By:____________________________

Title:_________________________

                                      14.
<PAGE>

                                   Exhibit A

                              SERIES A INVESTORS

OXFORD BIOSCIENCE PARTNERS, L.P.

OXFORD BIOSCIENCE PARTNERS (ADJUNCT), L.P.

OXFORD BIOSCIENCE PARTNERS (BERMUDA) LIMITED PARTNERSHIP

ATLAS VENTURE FUND II, L.P.

ATLAS VENTURE EUROPE FUND B.V.

Stelios Papadopoulos

CREATIVE BIOMOLECULES, INC.

EVOLUTION PARTNERS

PW PARTNERS 1993 L.P.

PAINEWEBBER CAPITAL, INC.

PAINEWEBBER CAPITAL INCORPORATED

                                      i.
<PAGE>

                                   Exhibit B

                              SERIES B INVESTORS

ADWEST LIMITED PARTNERSHIP

ADVENT PARTNERS LIMITED PARTNERSHIP

ADVENT PERFORMANCE MATERIALS LIMITED PARTNERSHIP

ADVENT INTERNATIONAL INVESTORS II LIMITED PARTNERSHIP

ROVENT II LIMITED PARTNERSHIP

OXFORD BIOSCIENCE PARTNERS L.P.

OXFORD BIOSCIENCE PARTNERS (ADJUNCT) L.P.

OXFORD BIOSCIENCE PARTNERS (BERMUDA) LIMITED PARTNERSHIP

ATLAS VENTURE FUND II, L.P.

ATLAS VENTURE EUROPE FUND B.V.

Stelios Papadopoulos

PAINEWEBBER CAPITAL, INC.

AXIOM VENTURE PARTNERS, L.P.

GIMV INVESTMENT COMPANY

HAMBRECHT & QUIST HEALTH CARE INVESTORS

HAMBRECHT & QUIST LIFE SCIENCES INVESTORS

NEW YORK LIFE INSURANCE COMPANY

Remi Barbier

Jeffrey M. Wiesen

Larry Abrams

Spyridon Artavanis-Tsakonas

Louis A. Mascelli

                                      ii.
<PAGE>

                                   Exhibit C

                              SERIES C INVESTORS

Bowman Capital Management
Pirate Ship & Co.
The Retirement Program of Farley Inc.
Biotechvest, L.P.
Fruit Of The Loom, Inc., Senior Executive Officer Deferred Compensation Plan
Maverick Fund USA, LTD.
Maverick Fund, LTD.
GLS L.P. Investment 1 Limited
Atlas Venture Fund II, L.P.
Atlas Venture Europe Fund B.V.
Oxford Bioscience Partners, L.P.
Oxford Bioscience Partners (Bermuda) Limited Partnership
H&Q Healthcare Investors
H&Q Life Science Investors
Prince Capital Master Fund, L.P.
Rovent H Limited Partnership
Advent Performance Materials Limited Partnership
Adwest Limited Partnership
Advent Partners Limited Partnership
PaineWebber Capital, Inc.
Moss Forest Venture
Armen Partners, L.P.
Armen Offshore
Axiom Venture Partners, L.P.
New York Life Insurance Company
Art Cohen
Steven Shapiro
Lance Willsey, MD
GIMV n.v.
Bayview Investors, LTD.
Stelios Papadopoulos
Eric Sichel, MD
David Williams
Joe Healy
Stuart Weisbrod
David Musket
Spyridon Artavanis-Tsakonas
Jim Dougherty, MD
Tom McAuley
R. Randolph Scott
Michael Gottlieb

                                     iii.
<PAGE>

                                   Exhibit D

                              SERIES D INVESTORS

Pharmacia & Upjohn AB
FEI Biomedicine Private Equity Holding Inc.
Advent Partners Limited Partnership
Advent International Investors II Limited Partnership
Advent Performance Materials Limited Partnership
Rovent II Limited Partnership
Atlas Venture Fund II, L.P.
Atlas Venture Europe Fund B.V.
Oxford Bioscience Partners, L.P.
Oxford Bioscience Partners (Bermuda) Limited Partnership
GIMV n.v.
Lynwood Corporation
Pharmacia & Upjohn AB
PainWebber Capital, Inc.

                                      iv.

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