Document:

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                                                                          [STSG]

                                WARRANT AGREEMENT

        This WARRANT AGREEMENT (this "Agreement") dated as of July 18, 2005 is
made by and between Vyteris Holdings (Nevada), Inc., a Nevada corporation
("Vyteris," the "Grantor" or the "Company") and Spencer Trask Specialty Group,
LLC, a Delaware limited liability company ("Holder").

        1.      GRANT. This Warrant is being granted in connection with a loan
made pursuant to a certain senior secured promissory note dated July 18, 2005
(the "Note"), with respect to a $300,000 loan made by the Holder to the Company.
Subject to the terms and conditions hereinafter set forth, the Holder is hereby
granted the right to purchase, initially, 2,500 shares of Vyteris common stock
subject to the increases discussed in Section 2 below. In the event that the
number of shares subject to this Warrant is so increased, the Holder shall
surrender its Warrant Certificates (as hereinafter defined) to the Company and
the Company shall reissue to the Holder a new Warrant Certificate reflecting the
increased amount of shares subject to the Warrant and the new Exercise Price (as
defined in Section 5.2 hereof) of the Warrant.

        2.      WARRANT CERTIFICATES. Simultaneously with the signing of this
Agreement, the Company shall issue to the Holder a warrant certificate (the
"Warrant Certificate") evidencing the Holder's right to purchase 2,500 shares of
Vyteris common stock. Unless the Outstanding Balance has been paid in full on or
before August 17, 2005, the Company shall issue to the Holder an additional
Warrant Certificate evidencing the Holder's right to purchase an additional
2,524 shares of Vyteris Common Stock. Additionally, if the Outstanding Balance
has not been paid in full on or before the Maturity Date (as defined in the
Note), the Company shall issue to the Holder an additional Warrant Certificate
evidencing the Holders right to purchase an additional 17,323 shares of Vyteris
Common Stock. Each Warrant Certificate delivered and to be delivered pursuant to
this Agreement shall be in the form set forth in EXHIBIT A attached hereto and
made a part hereof, with such appropriate insertions, omissions, substitutions,
and other variations as required or permitted by this Agreement.

        3.      EXERCISE OF THE WARRANTS.

        3.1     METHOD OF EXERCISE. The Warrants are initially exercisable for
Warrant Shares at the Exercise Price, subject to adjustment as provided in
Section 7 hereof, payable by certified or official bank check or cash. Upon
surrender of a Warrant Certificate with the annexed Form of Election to Purchase
duly executed, together with payment of the Exercise Price for the Warrant
Shares at the Company's principal offices, currently at 13-01 Pollitt Drive,
Fair Lawn, New Jersey 07410, the registered holder of a Warrant Certificate
("Holder" or "Holders") shall be entitled to receive a certificate or
certificates for the Warrant Shares so purchased. The purchase rights
represented by each Warrant Certificate are exercisable at the option of the
Holder(s) thereof, in whole or in part (but not as to fractional shares of the
Warrant Shares). The Warrants may be exercised to purchase all or part of the
Warrant Shares represented thereby. In the case of purchase of less than all the
Warrant Shares purchasable under any Warrant Certificate, the

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Company shall cancel such Warrant Certificate upon the surrender thereof and
shall execute and deliver a new Warrant Certificate of like tenor for the
balance of the Warrant Shares.

        3.2     NET EXERCISE BY SURRENDER OF THE WARRANTS. In addition to the
method of payment set forth in Section 3.1 and in lieu of any cash payment
required thereunder, the Holder(s) of the Warrants shall have the right at any
time and from time to time to exercise the Warrants in full or in part by
surrendering a Warrant Certificate in the manner specified in Section 3.1 in
exchange for the number of Warrant Shares computed by using the following
formula:

                     X = Y (A - B)
                         ---------
                             A

        Where  X  =  the number of Warrant Shares to be issued to the Holder(s)
                     pursuant to the net exercise.

               Y  =  the number of Warrant Shares subject to the Warrant being
                     exercised  or, if only a portion of such Warrant is being
                     exercised, the portion of such Warrant being canceled (at
                     the time of such calculation).

               A  =  the Fair Market Value of one share of Common Stock (at the
                     date of exercise).

               B  =  the Exercise Price (as adjusted to the date of such
                     calculation).

        For purposes of this Section 3.2, the "Fair Market Value" of one share
of Common Stock shall equal: (i) the average of the closing sale price of the
Common Stock (or any other security for which the Warrants are then exercisable)
as quoted on the Nasdaq Stock Market or in the Over-The-Counter Market or the
closing price quoted on any national securities exchange on which such
securities are listed, whichever is applicable, for the five trading days
immediately prior to the date of exercise or, (ii) if no sales take place on any
such trading day, the average of the closing bid and asked prices on such
trading day; or (iii) if the Common Stock (or any other security for which the
Warrants are then exercisable) is not quoted on the Nasdaq Stock Market or
Over-The-Counter or on a national securities exchange, the Fair Market Value of
the Common Stock shall be established in good faith by the disinterested members
of the Company's Board of Directors.

        3.3.    EXERCISE PERIOD. The Warrants shall be exercisable, in whole or
in part, during the term commencing on the Warrant Issue Date and ending on the
date five (5) years after the Warrant Issue Date (the "Expiration Time").

        4.      ISSUANCE OF CERTIFICATES.

        4.1     In the event of any exercise of the rights represented by the
Warrants, as promptly as practicable on or after the date of exercise and in any
event within ten (10) business days thereafter, the Company at its expense shall
issue and deliver to the Person or Persons (as

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hereinafter defined) entitled to receive the same a certificate or certificates
representing the number of Warrant Shares issued upon such exercise. In the
event that the Warrants are exercised in part, as promptly as practicable on or
after the date of exercise and in any event within ten (10) business days
thereafter, the Company at its sole expense will execute and deliver new
Warrants Certificates of like tenor exercisable for the number of Warrant Shares
for which the Warrants may then be exercised. As used herein, the term "Person"
or "Persons" means any individual or any corporation, partnership, trust,
limited liability company or other entity or organization of any kind.

        4.2     The issuance of the Warrant Shares upon the exercise of the
Warrants, and the delivery of certificates or other instruments representing
such Warrant Shares, shall be made without charge to the Holder(s) for any tax
or other charge of whatever nature in respect of such issuance and the Company
shall bear any such taxes in respect of such issuance.

        5.      EXERCISE PRICE.

        5.1     INITIAL AND ADJUSTED EXERCISE PRICE. Except as otherwise
provided in Section 7 hereof, the Warrants shall be exercisable to purchase
Warrant Shares at an initial price of $4.00 per share; PROVIDED, however, that
if the Outstanding Balance is not repaid on or before September 16, 2005, the
Exercise Price shall be adjusted to $3.58 per share. The adjusted Exercise Price
shall be the price that shall result from time to time from any and all
adjustments of the initial Exercise Price in accordance with the provisions of
Section 7 hereof.

        5.2     EXERCISE PRICE. The term "Exercise Price" herein shall mean the
initial exercise price or the adjusted exercise price, each as described in
Section 5.1 above, depending upon the context.

        6.      TRANSFER OF SECURITIES

        6.1     LEGENDS. Each Holder, by acceptance of a Warrant Certificate,
covenants and agrees that it is acquiring the Warrants evidenced thereby and the
Warrant Shares for its own account as an investment and not with a view to the
distribution thereof. The Warrants and Warrant Shares have not been registered
under the Securities Act of 1933 (the "Act"), or any state securities laws and
no transfer of any Warrant or Warrant Shares shall be permitted unless the
Company has received notice of such transfer, at the address of its principal
office set forth in Section 3.1 hereof, in the form of assignment attached
hereto, accompanied by an opinion of counsel reasonably satisfactory to the
Company that an exemption from registration of such Warrant or Warrant Shares
under the Act is available for such transfer.

               THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT
               BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
               AMENDED (THE "ACT"), OR THE SECURITIES LAWS OF ANY
               STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT
               PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER
               SUCH ACT AND APPLICABLE STATE SECURITIES LAWS OR

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               PURSUANT TO AN OPINION OF COUNSEL REASONABLY
               SATISFACTORY TO THE ISSUER THAT APPLICABLE EXEMPTION
               FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH
               LAWS IS AVAILABLE.

               THE TRANSFER, EXCHANGE AND EXERCISE OF THE WARRANTS
               REPRESENTED BY THIS CERTIFICATE ARE RESTRICTED IN
               ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO
               HEREIN.

        6.2     REMOVAL OF LEGEND. Upon request of a Holder of a certificate
with the legends required by Section 6.1 hereof, the Company shall issue to such
Holder a new certificate therefor free of any transfer legend, if, with such
request, the Company shall have received an opinion of counsel satisfactory to
the Company in form and substance to the effect that any transfer by such Holder
of the shares evidenced by such certificate will not violate the Act and any
applicable state securities laws. Any purported transfer of any Warrant or
Warrant Shares not in compliance with the provisions of this Section 6 shall be
null and void.

        7.      ADJUSTMENT OF EXERCISE PRICE OF THE WARRANT SHARES. The Exercise
Price of the Warrant Shares shall be subject to adjustment from time to time
upon the occurrence of certain events, as follows:

                (a)     ADJUSTMENT FOR RECLASSIFICATION, CONSOLIDATION OR
MERGER. If while any Warrant, or any portion thereof, remains outstanding and
unexpired there shall be (i) a reorganization or recapitalization (other than a
combination, reclassification, exchange or subdivision of shares otherwise
provided for herein), (ii) a merger or consolidation of the Company with or into
another Person in which the Company is not the surviving entity, or a reverse
merger in which the Company is the surviving entity but the shares of the
Company's capital stock outstanding immediately prior to the merger are
converted by virtue of the merger into other property, whether in the form of
securities, cash, or otherwise, or (iii) a sale or transfer of the Company's
properties and assets as, or substantially as, an entirety to any other Person
in one transaction or a series of related transactions, then, as a part of such
reorganization, recapitalization, merger, consolidation, sale or transfer,
unless otherwise directed by the Holder(s), all necessary or appropriate lawful
provisions shall be made so that the Holder(s) shall thereafter be entitled to
receive upon exercise of its Warrant, during the period specified herein and
upon payment of the Exercise Price then in effect, the greatest number of shares
of stock or other securities or property that a holder of Warrant Shares
deliverable upon exercise of such Warrant would have been entitled to receive in
such reorganization, recapitalization, consolidation, merger, sale or transfer
if such Warrants had been exercised immediately prior to such reorganization,
recapitalization, merger, consolidation, sale or transfer, all subject to
further adjustment as provided in this Section 7. If the per share consideration
payable to the Holder(s) for Warrant Shares in connection with any such
transaction is in a form other than cash or marketable securities, then the
value of such consideration shall be determined in good faith by the Company's
Board of Directors. The foregoing provisions of this paragraph shall similarly
apply to successive reorganizations, recapitalizations, consolidations, mergers,
sales and

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transfers and to the stock or securities of any other corporation that are at
the time receivable upon the exercise of such Warrant. In all events,
appropriate adjustment shall be made in the application of the provisions of the
Warrants (including adjustment of the Exercise Price and number of Warrant
Shares purchasable pursuant to the terms and conditions of the Warrants) with
respect to the rights and interests of the Holder(s) after the transaction, to
the end that the provisions of each Warrant shall be applicable after that
event, as near as reasonably may be, in relation to any shares or other property
deliverable or issuable after such reorganization, recapitalization, merger,
consolidation, sale or transfer upon exercise of each Warrant.

                (b)     ADJUSTMENTS FOR SPLIT, SUBDIVISION OR COMBINATION OF
WARRANT SHARES. If the Company at any time while the Warrants, or any portion
thereof, remain outstanding and unexpired shall split or subdivide any class of
securities as to which purchase rights under the Warrants exist, into a
different number of securities of the same class, the number of shares of such
class issuable upon exercise of the Warrants immediately prior to such split or
subdivision shall be proportionately adjusted and the Exercise Price for such
class of securities shall be proportionately adjusted. If the Company at any
time while the Warrants, or any portion thereof, remain outstanding and
unexpired shall combine any class of securities as to which purchase rights
under this Agreement exist, into a different number of securities of the same
class, the number of shares of such class issuable upon exercise of The Warrants
immediately prior to such combination shall be proportionately adjusted and the
Exercise Price for such class of securities shall be proportionately adjusted.

                (c)     ADJUSTMENTS FOR DIVIDENDS IN STOCK OR OTHER SECURITIES
OR PROPERTY. If while the Warrants, or any portion thereof, remain outstanding
and unexpired, the Holders shall have received, or, on or after the record date
fixed for the determination of eligible stockholders, shall have become entitled
to receive, without payment therefore, other or additional stock or other
securities or property (other than cash) of the Company by way of dividend, then
and in each case, the Warrants shall represent the right to acquire, in addition
to the number of shares of such class of security receivable upon exercise of
the Warrants, and without payment of any additional consideration therefore, the
amount of such other or additional stock or other securities or property (other
than cash) of the Company that such holder would hold on the date of such
exercise had it been the holder of record of the class of security receivable
upon exercise of the Warrants on the date hereof and had thereafter, during the
period from the date hereof to and including the date of such exercise, retained
such shares and/or all other additional stock available by it as aforesaid
during said period, giving effect to all adjustments called for during such
period by the provisions of this Section 7.

                (d)     ADJUSTMENT OF EXERCISE PRICE UPON ISSUANCE OF ADDITIONAL
SHARES OF COMMON STOCK. If while the Warrants, or any portion thereof, remain
outstanding and unexpired, the Company shall issue Additional Shares of Common
Stock (as hereinafter defined) without consideration or for a consideration per
share less than the then-applicable Exercise Price, then and in such event, such
Exercise Price shall be reduced, concurrently with such issue, to a price
(rounded up to the nearest cent) determined by multiplying the then-applicable
Exercise Price by a fraction, (i) the numerator of which shall be the number of
shares of the Company's Common Stock issued and outstanding (on an as-converted,
fully-diluted basis) immediately prior to such

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issuance plus the quotient obtained by dividing (x) the aggregate consideration
received by the Company for the total number of Additional Shares of Common
Stock so issued by (y) the Exercise Price, and (ii) the denominator of which
shall be the number of shares of the Common Stock issued and outstanding (on a
fully-diluted basis) immediately prior to such issuance plus the number of
Additional Shares of Common Stock so issued.

        For the purposes hereof "Additional Shares of Common Stock" shall mean
all shares of Common Stock, or options, rights, warrants to subscribe for common
stock, or securities convertible into or exchangeable for shares of common
stock, actually issued by the Company on or after the date hereof, other than
shares of common stock issued at any time:

                (i)     upon exercise of the Warrants;

                (ii)    pursuant to the exercise of options, warrants or other
common stock purchase rights issued (or to be issued) to employees, officers or
directors of, or consultants or advisors to, or any strategic ally of, the
Company pursuant to any stock purchase or stock option plan or other arrangement
approved by the Board of Directors;

                (iii)   pursuant to the exercise of options, warrants or any
evidence of indebtedness, shares of capital stock (other than common stock) or
other securities convertible into or exchangeable for the Company's common
stock; or

                (iv)    in connection with the acquisition of all or part of
another entity by stock acquisition, merger, consolidation or other
reorganization, or by the purchase of all or part of the assets of such other
entity (including securities issued to persons formerly employed by such other
entity and subsequently hired by the Company and to any brokers or finders in
connection therewith) where the Company or its stockholders own more than fifty
(50%) percent of the voting power of the acquired, surviving, combined or
successor company.

                (e)     NOTICE OF ADJUSTMENTS. Upon any adjustment of the
Exercise Price and any increase or decrease in the number of Warrant Shares
purchasable upon the exercise of the Warrants, then, and in each such case, the
Company, within 30 days thereafter, shall give written notice thereof to the
Holder(s) at the address of such Holder(s) as shown on the books of the Company
which notice shall state the Exercise Price as adjusted and, if applicable, the
increased or decreased number of Warrant Shares purchasable upon the exercise of
the Warrants, setting forth in reasonable detail the method of calculation of
each.

        8.      REGISTRATION RIGHTS.

                8.1     PIGGYBACK REGISTRATION. If, at any time commencing after
the date hereof until the Expiration Time, the Company proposes to register any
of its securities under the Securities Act of 1933, as amended (the "Act"),
(other than in connection with a merger, pursuant to Form S-8, S-4 or comparable
registration statement) it will give written notice by registered mail, at least
thirty (30) business days prior to the filing of each such registration
statement, to the registered Holder of the Warrant Shares of its intention to do
so. If the Holder

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of the Warrant Shares notifies the Company within twenty (20) days after receipt
of any such notice of its desire to include any Warrant Shares in such proposed
registration statement, the Company shall afford the Holder of the Warrant
Shares the opportunity to have any such Warrant Shares registered under such
registration statement.

        Notwithstanding the provisions of this Section 8.1, (A) the Company
shall have the right any time after it shall have given written notice pursuant
to this Section 8.1 (irrespective of whether a written request for inclusion of
any such securities shall have been made) to elect to postpone or not to file
any such proposed registration statement, or to withdraw the same after filing
but prior to the effective date thereof and (B) if the underwriter or
underwriters, if any, of any such proposed public offering shall be of the
reasonable opinion that the total amount or kind of securities held by the
Holders of Warrant Shares and any other persons or entities entitled to be
included in such public offering would adversely affect the success of such
public offering, then the amount of securities to be offered for the accounts of
Holders of Warrant Shares shall be reduced pro rata to the extent necessary to
reduce the total amount of securities to be included in such public offering to
the amount reasonably recommended by the underwriter or underwriters thereof,
whereupon the Company shall only be obligated to register such limited portion
(which may be none) of the Warrant Shares with respect to which such holder has
provided notice pursuant to this Section 8.1. In no event shall the Company be
required pursuant to this Section 8.1 to reduce the amount of securities to be
registered by it.

        8.2.    COVENANTS OF THE COMPANY WITH RESPECT TO REGISTRATION. In
connection with any registration under the previous paragraph, the Company
covenants and agrees as follows: (i) the Company shall use its best efforts to
file a registration statement as soon as practicable and shall use its best
efforts to have any registration statement declared effective at the earliest
possible time, and shall furnish Holder desiring to sell the Warrant Shares such
number of prospectuses as shall reasonably be requested; (ii) the Company shall
pay all costs (excluding fees and expenses of Holder's counsel and any
underwriting or selling commissions or other charges of any broker-dealer acting
on behalf of such Holder), fees and expenses in connection with all registration
statements filed pursuant to the previous paragraph including, without
limitation, the Company's legal and accounting fees, printing expenses, blue sky
fees and expenses; (iii) the Company shall take all necessary action which may
be required in qualifying or registering the Warrant Shares included in the
registration statement for offering and sale under the securities or blue sky
laws of such states as reasonably are requested by the Holder, provided that the
Company shall not be obligated to execute or file any general consent to service
of process or to qualify as a foreign corporation to do business under the laws
of any such jurisdiction; (iv) the Company shall indemnify the Holder of the
Warrant Shares to be sold pursuant to any registration statement and each
person, if any, who controls such Holder within the meaning of Section 15 of the
Act or Section 20(a) of the Exchange Act of 1934, as amended (the "Exchange
Act"), against all loss, claim, damage, expense or liability (including all
expenses reasonably incurred in investigating, preparing or defending against
any claim whatsoever) to which any of them may become subject which relate to
any registration statement(s) prepared in connection herewith; (v) the Holder of
the Warrant Shares to be sold pursuant to a registration statement, and their
successors and assigns, shall severally and not jointly indemnify the Company,
its officers and directors and each person, if any, who controls the Company
within the meaning of Section 15 of the Act or

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Section 20(a) of the Exchange Act, against all loss, claim, damage or expense or
liability (including all expenses reasonably incurred in investigating,
preparing or defending against any claim whatsoever) to which they may become
subject under the Act, the Exchange Act or otherwise, arising from any
information furnished by or on behalf of such Holder, or their successors or
assigns, for specific inclusion in such a registration statement; (vi) nothing
contained in this Warrant shall be construed as requiring the Holder to exercise
this Warrant prior to the initial filing of any registration statement or the
effectiveness thereof; (vii) the Company shall prepare and file with the
Securities and Exchange Commission (the "Commission") such amendments,
post-effective amendments and supplements to the registration statement and the
prospectus included therein as may be necessary to keep the registration
statement effective until the later of (i) the date when all Warrant Shares
registered have been sold or (ii) until such time as the Warrant Shares are free
of restriction on resale under the Act (by removal of all restrictive legends,
instructions to transfer or otherwise) pursuant to Rule 144; and comply with the
provisions of the Act with respect to the disposition of all securities covered
by such registration statement during the applicable period in accordance with
the intended method or methods of distribution by the sellers thereof as set
forth in such registration statement or supplement of the prospectus; (viii) the
Company shall furnish to the Holder participating in an offering including
Warrant Shares and to each underwriter, if any, a signed counterpart, addressed
to the Holder or underwriter, of (A) an opinion of counsel to the Company, dated
the effective date of such registration statement (and, if such registration
includes an underwritten public offering, an opinion dated the date of the
closing under the underwriting agreement), and (B) a "cold comfort" letter dated
the effective date of such registration statement (and, if such registration
includes an underwritten public offering, a letter dated the date of the closing
under the underwriting agreement) signed by the independent public accountants
who have issued a report on the Company's financial statements included in such
registration statement, in each case covering substantially the same matters
with respect to such registration statement (and the prospectus included
therein) and, in the case of such accountants' letter, with respect to events
subsequent to the date of such financial statements, as are customarily covered
in opinions of issuer's counsel and in accountants' letters delivered to
underwriters in underwritten public offerings of securities; (vii) the Company
shall, as soon as practicable after the effective date of a registration
statement relating to any Warrant Shares pursuant to the previous paragraph, and
in any event within fifteen (15) months thereafter, use its reasonable efforts
to make "generally available to its security holders" (within the meaning of
Rule 158 under the Act) an earnings statement (which need not be audited)
complying with Section 11(a) of the Act and covering a period of at least (12)
consecutive months beginning after the effective date of the registration
statement; and (viii) upon the written request of the Holder, the Company shall
deliver promptly to the Holder participating in an offering including any
Warrant Shares pursuant to the previous paragraph who so requests and to the
managing underwriter, copies of all correspondence between the Commission and
the Company, its counsel or auditors and all memoranda relating to discussions
with the Commission or its staff with respect to the registration statement and
shall permit the Holder and underwriter to do such investigation, upon
reasonable advance notice, with respect to information contained in or omitted
from the registration statement as it deems reasonably necessary to comply with
applicable securities laws or rules of the National Association of Securities
Dealers, Inc. ("NASD"). Such investigation shall include access to books,
records and properties and

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opportunities to discuss the business of the Company with its officers and
independent auditors, all to such reasonable extent and at such reasonable times
and as often as any such Holder shall reasonably request as it deems necessary
to comply with applicable securities laws and NASD rules.

        9.      EXCHANGE AND REPLACEMENT OF WARRANT CERTIFICATES. Each Warrant
Certificate is exchangeable without expense, upon the surrender thereof by the
registered Holder(s) at the principal office of the Company, for a new Warrant
Certificate of like form, tenor and date representing in the aggregate the right
to purchase the same number of securities in such denominations as shall be
designated by the Holder(s) thereof at the time of such surrender.

        Upon receipt by the Company of evidence reasonably satisfactory to it of
the loss, theft, destruction or mutilation of any Warrant Certificate, and, in
case of loss, theft or destruction, of indemnity or security reasonably
satisfactory to it, and reimbursement to the Company of all reasonable expenses
incidental thereto, and upon surrender and cancellation of the Warrants, if
mutilated, the Company will make and deliver a new Warrant Certificate of like
form and tenor in lieu thereof.

        10.     FRACTIONAL SHARES. No fractional shares will be issued in
connection with any exercise hereunder. Instead, the Company shall pay to
Holder(s) an amount in cash equal to any fractional share to which the Holder(s)
would be entitled, multiplied by the Fair Market Value of the Common Stock.

        11.     STOCK FULLY PAID; RESERVATION OF SHARES. The Company shall at
all times reserve and keep available out of its authorized Common Stock, solely
for the purpose of issuance upon the exercise of the Warrants, such number of
Warrant Shares into which Warrants are exercisable. The Company covenants and
agrees that, upon exercise of the Warrants and payment of the Exercise Price
therefore, all shares of Common Stock shall be duly and validly issued, fully
paid, non-assessable and not subject to the preemptive rights of any
stockholder.

        12.     RIGHTS OF STOCKHOLDERS. Except as expressly provided in Section
3 hereof, no Holder, as such, shall be entitled to vote or receive dividends or
be deemed the holder of the Warrant Shares or any other securities of the
Company that may at any time be issuable on the exercise hereof for any purpose,
nor shall anything contained herein be construed to confer upon the Holder(s),
as such, any of the rights of a stockholder of the Company or any right to vote
for the election of directors or upon any matter submitted to stockholders at
any meeting thereof, or to give or withhold consent to any corporate action
(whether upon any recapitalization, issuance of stock, reclassification of
stock, change of par value, consolidation, merger, conveyance, or otherwise) or
to receive notice of meetings, or to receive dividends or subscription rights or
otherwise until the Warrants shall have been exercised and the Warrant Shares
purchasable upon the exercise thereof shall have been issued, as provided
herein.

        13.     NOTICES. All notices, requests, consents and other
communications hereunder shall be in writing and shall be deemed to have been
duly made when delivered, or mailed by registered or certified mail, return
receipt requested:

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        13.1    If to a registered Holder(s) of the Warrants, to the address of
such Holder(s) as shown on the books of the Company; or

        13.2    If to the Company, at 13-01 Pollitt Drive, Fair Lawn, New Jersey
07410, Attention: Vincent L. DeCaprio Ph.D., President, or Michael McGuinness,
Chief Financial Officer, or at such other address as may have been furnished in
writing by the Company, with a copy to Lowenstein Sandler PC, 65 Livingston
Avenue, Roseland, New Jersey 07068, Attention: Peter H. Ehrenberg, Esq.; or

        14.     SUPPLEMENTS AND AMENDMENTS. The Company may from time to time
supplement or amend this Agreement without the approval of any Holder(s) in
order to cure any ambiguity, to correct or supplement any provision contained
herein which may be defective or inconsistent with any provision herein, or to
make any other provisions in regard to matters or questions arising hereunder
which the Company may deem necessary or desirable and which the Company deems
shall not adversely affect the interests of the Company and/or the Holder(s).
Other amendments to this Agreement may be made only with the written consent of
the Company and the Holder(s) of the majority of the outstanding Warrant Shares
issuable upon exercise of the Warrants.

        15.     SUCCESSORS. All the covenants and provisions of this Agreement
shall be binding upon and inure to the benefit of the Company, the Holder(s) and
their respective successors and assigns hereunder.

        16.     TERMINATION. This Agreement shall terminate at the close of
business on the expiration time.

        17.     GOVERNING LAW. This Agreement shall be governed by and
construed, interpreted and enforced in accordance with the law of the State of
New Jersey and the federal law of the United States without regard to the law of
any other jurisdiction.

        18.     WAIVER OF TRIAL BY JURY AND CLAIMS TO CERTAIN DAMAGES. THE
BORROWER KNOWINGLY, VOLUNTARILY, INTENTIONALLY AND IRREVOCABLY WAIVES EACH RIGHT
THE BORROWER MAY HAVE TO A TRIAL BY JURY WITH RESPECT TO, AND EACH RIGHT TO
ASSERT ANY CLAIM FOR DAMAGES (INCLUDING, BUT NOT LIMITED TO, PUNITIVE DAMAGES)
IN ADDITION TO ACTUAL DAMAGES IN, ANY ACTION OR OTHER LEGAL PROCEEDING, WHETHER
BASED ON ANY CONTRACT OR NEGLIGENT, INTENTIONAL OR OTHER TORT OR OTHERWISE,
ARISING OUT OF OR OTHERWISE RELATING TO (A) THE CREDIT, ANY LOAN OR COLLATERAL,
THIS NOTE OR ANY OTHER WRITING HERETOFORE OR HEREAFTER EXECUTED IN CONNECTION
WITH THE CREDIT OR ANY LOAN OR COLLATERAL, (B) ANY TRANSACTION ARISING OUT OF OR
OTHERWISE RELATING TO THE CREDIT, ANY LOAN OR COLLATERAL, THIS NOTE OR ANY SUCH
OTHER WRITING OR (C) ANY NEGOTIATION, ADMINISTRATION,

                                       10
<PAGE>

PERFORMANCE OR ENFORCEMENT OF THE CREDIT, ANY LOAN OR COLLATERAL, THIS NOTE OR
ANY SUCH OTHER WRITING.

        19.     ENTIRE AGREEMENT; MODIFICATION. This Agreement contains the
entire understanding between the parties hereto with respect to the subject
matter hereof and may not be modified or amended except as provided in Section
13 hereof.

        20.     SEVERABILITY. If any provision of this Agreement shall be held
to be invalid and unenforceable, such invalidity or unenforceability shall not
affect any other provision of this Agreement.

        21.     CAPTIONS. The caption headings of the Sections of this Agreement
are for convenience of reference only and are not intended, nor should they be
construed, as a part of this Agreement and shall be given no substantive effect.

        22.     BENEFITS OF THIS AGREEMENT. Nothing in this Agreement shall be
construed to give to any person, entity or corporation other than the Company
and any registered Holder(s) of the Warrant Certificates, Warrant Shares any
legal or equitable right, remedy or claim under this Agreement; and this
Agreement shall be for the sole and exclusive benefit of the Company and the
Holder(s) of the Warrant Certificates or Warrant Shares.

        23.     COUNTERPARTS. This Agreement may be executed in any number of
counterparts and each of such counterpart shall for all purposes be deemed to be
an original, and such counterparts shall together constitute but one and the
same instrument.

        24.     ASSIGNMENT. Any Person or Persons to whom the Warrants are
transferred by a Holder shall agree to be bound by all of the provisions hereof;
and the transferring Holder shall not transfer any Warrants unless the
transferring Holder first provides a written instrument to the Company notifying
the Company of such transfer pursuant to which the transferee agrees in writing
to be bound by the terms of this Agreement.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       11
<PAGE>

        IN WITNESS WHEREOF, the parties hereto have caused this Warrant
Agreement to be duly executed as of the day and year first above written.

                                       VYTERIS HOLDINGS (NEVADA), INC.

                                       By: /s/ Michael McGuinness
                                           ----------------------
                                           Name: Michael McGuinness
                                           Title: Vice President and Chief
                                                  Financial Officer

                                       HOLDER:

                                       SPENCER TRASK SPECIALTY GROUP LLC
                                       By:

                                            By:   /s/ William P. Dioguardi
                                                  ------------------------
                                            Name: William P. Dioguardi
                                            Title:

                                       12
<PAGE>

                                    EXHIBIT A

                          [FORM OF WARRANT CERTIFICATE]

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR THE SECURITIES LAWS OF
ANY STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT PURSUANT TO (i) AN
EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES
LAWS OR (ii) AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO THE ISSER, THAT
AN APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH
LAWS IS AVAILABLE.

THE TRANSFER, EXCHANGE AND EXERCISE OF THE WARRANTS REPRESENTED BY THIS
CERTIFICATE ARE RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO
HEREIN.

No. St-__                                                        _______Warrants
                                                              _________ __, 2005

                               WARRANT CERTIFICATE

        This Warrant Certificate certifies that _________________________, or
its registered assigns, is the registered holder of ____________________
warrants (the "Warrants") to purchase initially, at any time after the date
hereof ("Warrant Issue Date") until 5:30 p.m. New York time on ____________ __,
2009 (the "Expiration Date"), up to ___________ fully paid and non-assessable
shares of Common Stock, $0.0001 par value per share ("Common Stock") of the
Company, at the initial exercise price, subject to adjustment in certain events
(the "Exercise Price"), of $4.00 upon surrender of this Warrant Certificate and
payment of the Exercise Price at an office or agency of the Company, or by
surrender of this Warrant Certificate in lieu of cash payment, but subject to
the conditions and adjustments set forth in the Warrant Agreement dated as of
July 18, 2005, entered into by and among the Company and each holder of Warrants
(the "Warrant Agreement"). Except as otherwise provided in Section 3.2 of the
Warrant Agreement, payment of the Exercise Price shall be made by certified or
official bank check in New York Clearing House funds payable to the order of the
Company.

        No Warrant may be exercised after 5:30 p.m. (New York time) on the
Expiration Date, at which time the Warrants evidenced hereby, unless exercised
prior thereto, shall thereafter be void.

        The Warrants evidenced by this Warrant Certificate are part of a duly
authorized issue of Warrants issued pursuant to the Warrant Agreement, which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and to which reference is hereby made for a description of the
rights, limitations of rights, obligations, duties and immunities thereunder of
the Company and the registered holder(s) of the Warrants.

                                       13
<PAGE>

        As set forth in Section 7 of in the Warrant Agreement, certain
adjustments may be made to the Exercise Price and the type and/or number of the
Company's securities issuable upon their exercise. In the event of such an
adjustment, the Company will, at the request of the holder, issue a new Warrant
Certificate evidencing the adjustment in the Exercise Price and the number
and/or type of securities issuable upon the exercise of the Warrants; PROVIDED,
HOWEVER, that the failure of the Company to issue such new Warrant Certificates
shall not in any way change, alter or otherwise impair the rights of the holder
as set forth in the Warrant Agreement.

        Upon due presentment of transfer of this Warrant Certificate and the
executed form of assignment attached hereto at an office or agency of the
Company, a new Warrant Certificate or Warrant Certificates of like form and
tenor and evidencing in the aggregate a like number of Warrants shall be issued
to the transferee(s) in exchange for this Warrant Certificate, subject to the
limitations provided herein and in the Warrant Agreement, without any charge
except for any tax or other governmental charge imposed in connection with such
transfer.

        Upon the exercise of less than all of the Warrants evidenced by this
Warrant Certificate, the Company shall forthwith issue to the holder hereof a
new Warrant Certificate representing such number of unexercised Warrants.

        The Company may deem and treat the registered holder(s) hereof as the
absolute owner(s) of this Warrant Certificate (notwithstanding any notation of
ownership or other writing hereon made by anyone), for the purpose of any
exercise hereof, and of any distribution to the holder(s) hereof, and for all
other purposes, and the Company shall not be affected by any notice to the
contrary.

        All capitalized terms used and not defined in this Warrant Certificate
shall have the meanings ascribed to them in the Warrant Agreement.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       14
<PAGE>

        IN WITNESS WHEREOF, the Company has caused this Warrant Certificate to
be duly executed as of _____________ __, 200_.

                                          VYTERIS, INC.

                                          By: _________________________________
                                              Name: Vincent L. DeCaprio, Ph.D.
                                              Title: President

Attest:

_____________________________
Secretary

                                       15
<PAGE>

                         [FORM OF ELECTION TO PURCHASE]

TO:     Vyteris, Inc.
        Attention: President

        1.      The undersigned hereby irrevocably elects to exercise the right,
represented by the attached Warrant Certificate, to purchase _______________
(leave blank if you choose Alternative No. 2 below) shares of Common Stock
pursuant to the terms of the Warrant Agreement entered into by and among
Vyteris, Inc. and the holders of the Warrants, dated __________ ___, 200__ (the
"Warrant Agreement"), and tenders herewith payment of the purchase price of such
shares in full. (Initial here if the undersigned elects this alternative).
_________

        2.      In lieu of exercising the attached Warrant Certificate for cash
or check, the undersigned hereby elects to effect the net exercise provision set
forth in Section 3.2 of the Warrant Agreement and receive ____________ (leave
blank if you choose Alternative No. 1 above) shares of Common Stock of the
Company. (Initial here if the undersigned elects this alternative). ___________

        Capitalized terms used and not herein defined shall have the meanings
ascribed to them in the Warrant Agreement.

        Please issue a certificate or certificates representing said securities
in the name of the undersigned or in such other name as is specified below:

                   _________________________________________
                                     (Name)

                   _________________________________________

                   _________________________________________
                                    (Address)

                                          ______________________________________
                                          (Signature and Date)

                                          (Signature must conform in all
                                          respects to name of holder as
                                          specified on the face of the Warrant
                                          Certificate)

                                          ______________________________________
                                          (Insert Social Security or Other
                                          Identifying Number of Holder)

<PAGE>

                              [FORM OF ASSIGNMENT]

             (To be executed by the registered holder if such holder
                  desires to transfer the Warrant Certificate)

        FOR VALUE RECEIVED ________________________________ (the "Transferor")
hereby sells, assigns and transfers unto _____________________________________
(the "Transferee")

                  (Please print name and address of transferee)

this Warrant Certificate, together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint ______________________ as its
Attorney to transfer the within Warrant Certificate on the books of Vyteris,
Inc., with full power of substitution. The Transferor has provided a written
instrument to the Company notifying the Company of such transfer and pursuant to
which the Transferee hereunder has agreed in writing to be bound by the terms of
the Warrant Agreement dated __________ __, 200__ by, between and among Vyteris,
Inc., a Delaware corporation, and the holders of the Warrants a copy of which
has been provided to the Transferee by the Transferor.

Dated:                              Signature___________________________________
                                    (Signature must conform in all respects to
                                    name of holder as specified on the face of
                                    the Warrant Certificate)

                                    ____________________________________________
                                    (Insert Social Security or other Identifying
                                    Number of Holder)

                                       17<PAGE>

                                            [SPENCER TRASK SPECIALTY GROUP, LLC]

                             SUBSCRIPTION AGREEMENT

To:     Vyteris Holdings (Nevada), Inc.

Ladies and Gentlemen:

        1.      Subscription. The undersigned (the "LENDER"), intending to be
legally bound, hereby irrevocably agrees to make a loan of $250,000 in aggregate
principal amount (the "LOAN") to Vyteris Holdings (Nevada), Inc. (the "COMPANY")
and receive from the Company a promissory note in that amount and in the form
annexed hereto as ANNEX A (the "NOTE") and warrants (the "WARRANTS"), initially
exercisable into 3,125 shares of the Company's common stock, in the form
attached as an exhibit to the form of Warrant Agreement annexed hereto as ANNEX
B (the "WARRANT AGREEMENT"). The Note will be secured by the assets of the
Company pursuant to a Security Agreement in the form annexed hereto as ANNEX C
(the "SECURITY AGREEMENT"). The Lender is, simultaneously herewith, making a
wire transfer payment to the Company in the full amount of the Loan. The shares
of Company common stock into which the Warrants are or may become exercisable
are referred to herein as the "CONVERSION SHARES."

        2.      Representations and Warranties. The Lender hereby represents,
warrants, acknowledges and agrees as follows:

                (a)     None of the Note, the Warrants nor the Conversion Shares
registered under the Securities Act of 1933, as amended (the "SECURITIES ACT"),
or any state securities laws. The Lender understands that the issuance of the
Note, the Warrants and the Conversion Shares is intended to be exempt from
registration under the Securities Act, by virtue of Section 4(2) thereof and the
provisions of Regulation D promulgated thereunder, based, in part, upon the
representations, warranties and agreements of the Lender contained in this
Subscription Agreement;

                (b)     Neither the Securities and Exchange Commission nor any
state securities commission has approved the Note, the Warrants or the
Conversion Shares, or passed upon or endorsed the merits of thereof;

                (c)     The Lender and its advisors have had a reasonable
opportunity to ask questions of and receive answers from a person or persons
acting on behalf of the Company concerning the Company and the Note, the
Warrants and the Conversion Shares and all such questions have been answered to
the full satisfaction of the Lender and its advisors, if any;

                (d)     In evaluating its decision to make the Loan and accept
the Note, the Warrants and the Conversion Shares, the Lender has not relied upon
any representation or other information (oral or written) made by the Company or
anyone on its behalf;

                (e)     The Lender is unaware of, is in no way relying on, and
did not become aware of the Note, the Warrants and the Conversion Shares through
or as a result of, any form of general solicitation or general advertising
including, without limitation, any article, notice, advertisement or other
communication published in any newspaper, magazine or similar media or broadcast
over television or radio, and did not become aware of the Note, the Warrants or
the Conversion Shares through or as a result of any seminar or meeting to which
the Lender

<PAGE>

was invited by, or any solicitation of a subscription by, a person not
previously known to the Lender in connection with investments in securities
generally;

                (f)     The Lender has such knowledge and experience in
financial, tax, and business matters, and, in particular, investments in
securities, so as to enable it to utilize the information made available to it
in connection with the Loan and the Note, the Warrants and the Conversion Shares
to evaluate the merits and risks of making the Loan and accepting the Note, the
Warrants and the Conversion Shares, and to make an informed investment decision
with respect thereto;

                (g)     The Lender is not relying on the Company or any of its
employees or agents with respect to the legal, tax, economic and related
considerations as to making the Loan or accepting the Note, the Warrants and the
Conversion Shares, and the Lender has relied on the advice of, or has consulted
with, only its own advisors;

                (h)     The Lender is acquiring the Note, the Warrants and the
Conversion Shares solely for its own account for investment and not with a view
to resale, assignment or distribution thereof, in whole or in part. The Lender
has no agreement or arrangement, formal or informal, with any person to sell or
transfer all or any part of the Note, the Warrants and the Conversion Shares,
and the Lender has no plans to enter into any such agreement or arrangement;

                (i)     The Lender must bear the substantial economic risks of
the Note, the Warrants and the Conversion Shares indefinitely because none of
the Note, the Warrants and the Conversion Shares may be sold, hypothecated or
otherwise disposed of unless subsequently registered under the Securities Act
and applicable state securities laws or an exemption from such registration is
available. Legends shall be placed on the Note, the Warrants and the Conversion
Shares to the effect that they have not been registered under the Securities Act
or applicable state securities laws and appropriate notations thereof will be
made in the Company's stock books. Stop transfer instructions will be placed
with the transfer agent of the Note, the Warrants and the Conversion Shares;

                (j)     The Lender has adequate means of providing for its
current financial needs and foreseeable contingencies and has no need for
liquidity of the Note, the Warrants and the Conversion Shares for an indefinite
period of time;

                (k)     The Lender meets the requirements of at least one of the
suitability standards for an "accredited investor" as set forth on the
Accredited Investor Certification contained herein;

                (l)     The Lender:

                        (i)     if a natural person, represents that the Lender
has reached the age of 21 and has full power and authority to execute and
deliver this Subscription Agreement, the Warrant Agreement and the Security
Agreement and all other related agreements or certificates and to carry out the
provisions hereof and thereof (collectively referred to herein as the
"SUBSCRIPTION DOCUMENTS");

                                       2
<PAGE>

                        (ii)    if a corporation, partnership, limited liability
company or partnership, association, joint stock company, trust, unincorporated
organization or other entity, either such entity was not formed for the specific
purpose of acquiring the Note, the Warrants and the Conversion Shares or all of
the equity owners of such entity meet the requirement of at least one of the
suitability standards for an "accredited investor" as set forth on the
Accredited Investor Certification contained herein, such entity is duly
organized, validly existing and in good standing under the laws of the state of
its organization, the consummation of the transactions contemplated hereby is
authorized by, and will not result in a violation of state law or its charter or
other organizational documents, such entity has full power and authority to
execute and deliver the Subscription Documents and all other related agreements
or certificates and to carry out the provisions hereof and thereof and to
acquire and hold the Note, the Warrants and the Conversion Shares, the execution
and delivery of the Subscription Documents have been duly authorized by all
necessary action, the Subscription Documents have been duly executed and
delivered on behalf of such entity and is a legal, valid and binding obligation
of such entity; and

                        (iii)   if executing this Subscription Agreement in a
representative or fiduciary capacity, the undersigned has full power and
authority to execute and deliver the Subscription Documents in such capacity and
on behalf of the subscribing individual, ward, partnership, trust, estate,
corporation, limited liability company or limited liability partnership, or
other entity for whom the undersigned is executing the Subscription Documents,
and such individual, ward, partnership, trust, estate, corporation, limited
liability company or partnership, or other entity has full right and power to
perform pursuant to the Subscription Documents and make an investment in the
Company, and that the Subscription Documents constitute legal, valid and binding
obligations of such entity.

                (m)     The execution and delivery of the Subscription Documents
will not violate or be in conflict with any order, judgment, injunction,
agreement or controlling document to which the Lender is a party or by which it
is bound;

                (n)     The Lender has significant prior investment experience,
including investment in non-listed and non-registered securities. The Lender has
a sufficient net worth to sustain a loss of its entire investment in the Company
in the event such a loss should occur. The Lender's overall commitment to
investments which are not readily marketable is not excessive in view of its net
worth and financial circumstances and the Loan will not cause such commitment to
become excessive. The investment is a suitable one for the Lender;

                (o)     The Lender is satisfied that it has received adequate
information with respect to all matters which it or its advisors consider
material to its decision to make this investment;

                (p)     The Lender has a pre-existing business relationship with
Spencer Trask Ventures, Inc. and/or one of its related parties; and

                (q)     THE NOTE, THE WARRANTS AND THE CONVERSION SHARES HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE
SECURITIES LAWS OF CERTAIN STATES AND ARE BEING OFFERED AND SOLD IN RELIANCE ON
EXEMPTIONS FROM THE REGISTRATION

                                       3
<PAGE>

REQUIREMENTS OF SAID ACT AND SUCH LAWS. THE NOTE, THE WARRANTS AND THE
CONVERSION SHARES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND
MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER SAID ACT AND SUCH
LAWS PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM. THE NOTE, THE WARRANTS AND
THE CONVERSION SHARES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES
AND EXCHANGE COMMISSION, ANY STATE SECURITIES COMMISSION OR ANY OTHER REGULATORY
AUTHORITY, NOR HAVE ANY OF THE FOREGOING AUTHORITIES PASSED UPON OR ENDORSED THE
MERITS THEREOF. ANY REPRESENTATION TO THE CONTRARY IS UNLAWFUL.

        3.      Applicable Law. This Subscription Agreement shall be governed by
and construed in accordance with the laws of the State of New York relating to
contracts entered into and to be performed wholly within such State.

        4.      Confidentiality. The Lender acknowledges and agrees that any
information or data it has acquired from or about the Company, not otherwise
properly in the public domain, was received in confidence. The Lender agrees not
to divulge, communicate or disclose, except as may be required by law or for the
performance of the Subscription Documents, or use to the detriment of the
Company or for the benefit of any other person or persons, or misuse in any way,
any confidential information of the Company, including any scientific,
technical, trade or business secrets of the Company and any scientific,
technical, trade or business materials that are treated by the Company as
confidential or proprietary, including, but not limited to, ideas, discoveries,
inventions, developments and improvements belonging to the Company and
confidential information obtained by or given to the Company about or belonging
to third parties.

        5.      Miscellaneous.

                (b)     This Subscription Agreement, together with the Warrant
Agreement, the Security Agreement, the Note and Warrant, constitute the entire
agreement between the Lender and the Company with respect to the subject matter
hereof and supersede all prior oral or written agreements and understandings, if
any, relating to the subject matter hereof. The terms and provisions of this
Subscription Agreement may be waived, or consent for the departure therefrom
granted, only by a written document executed by the party entitled to the
benefits of such terms or provisions.

                (c)     The Lender's covenants, agreements, representations and
warranties made in this Subscription Agreement shall survive the execution and
delivery hereof and delivery of the Note, the Warrants and the Conversion
Shares.

                (d)     Each of the parties hereto shall pay its own fees and
expenses (including the fees of any attorneys, accountants, appraisers or others
engaged by such party) in connection with this Subscription Agreement and the
transactions contemplated hereby whether or not the transactions contemplated
hereby are consummated.

                                       4
<PAGE>

                (e)     This Subscription Agreement may be executed in one or
more counterparts each of which shall be deemed an original, but all of which
shall together constitute one and the same instrument.

                (f)     Each provision of this Subscription Agreement shall be
considered separable and, if for any reason any provision or provisions hereof
are determined to be invalid or contrary to applicable law, such invalidity or
illegality shall not impair the operation of or affect the remaining portions of
this Subscription Agreement.

                (g)     Paragraph titles are for descriptive purposes only and
shall not control or alter the meaning of this Subscription Agreement as set
forth in the text.

        6.      Amendment to the Security Agreement. Notwithstanding anything to
the contrary set forth in the Security Agreement, the Security Agreement is
hereby amended such that upon the Lender's execution of this Subscription
Agreement in accordance with Section 7 below, the Lender shall become a
Noteholder (as defined in the Security Agreement) and the terms of the note and
the warrants described in such Security Agreement shall be the terms set forth
in the Note and the Warrant annexed hereto, rather than the terms set forth in
the SPA described in such Security Agreement.

        7.      Omnibus Signature Page. This Subscription Agreement is intended
to be read and construed in conjunction with the Warrant Agreement, the Security
Agreement, the Note and the Warrant. Accordingly, pursuant to the terms and
conditions of this Subscription Agreement and such related agreements it is
hereby agreed that the execution by the Lender of this Subscription Agreement,
in the place set forth herein, shall constitute agreement to be bound by the
terms and conditions hereof and the terms and conditions of the Warrant
Agreement and the Security Agreement (as amended pursuant to Section 6 of this
Subscription Agreement), with the same effect as if each of such separate but
related agreement were separately signed.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       5
<PAGE>

                         VYTERIS HOLDINGS (NEVADA), INC.
                            OMNIBUS SIGNATURE PAGE TO
                  SUBSCRIPTION AGREEMENT, WARRANT AGREEMENT AND
                               SECURITY AGREEMENT

Date (NOTE: To be completed by subscriber): May 27, 2005

--------------------------------------------------------------------------------
If the Purchaser is an INDIVIDUAL, and if purchased as JOINT TENANTS, as TENANTS
IN COMMON, or as COMMUNITY PROPERTY:

      ----------------------------           ------------------------------
      PRINT NAME(S)                          SOCIAL SECURITY NUMBER(S)

      ---------------------------            ------------------------------
      SIGNATURE(S) OF SUBSCRIBER(S)          SIGNATURE

      ----------------------------           ------------------------------
      DATE                                   ADDRESS

If the Purchaser is a PARTNERSHIP, CORPORATION, LIMITED LIABILITY COMPANY or
TRUST:

      SPENCER TRASK SPECIALTY
      GROUP, LLC
      ----------------------------           ------------------------------
      NAME OF PARTNERSHIP,                   FEDERAL TAXPAYER
      CORPORATION, LIMITED                   IDENTIFICATION NUMBER
      LIABILITY COMPANY OR TRUST

      BY: /s/ William P. Dioguardi           NEW YORK
         -------------------------           ------------------------------
      NAME: WILLIAM P. DIOGUARDI             STATE OF ORGANIZATION
      TITLE:

                                             535 MADISON AVENUE,
      May 27, 2005                           NEW YORK, NY 10022
      ----------------------------           ------------------------------
      DATE                                   ADDRESS

VYTERIS HOLDINGS (NEVADA), INC.

By:  /s/ Vincent DeCaprio
     --------------------
     Name: Vincent DeCaprio, Ph.D.
     Title: President and Chief Executive Officer

                                       6
<PAGE>

                        ACCREDITED INVESTOR CERTIFICATION
                         Initial the appropriate item(s)

THE UNDERSIGNED FURTHER REPRESENTS AND WARRANTS AS INDICATED BELOW BY THE
UNDERSIGNED'S INITIALS:

A. INDIVIDUAL LENDER: (Please INITIAL one or more of the following five
   statements)

1._____ I certify that I am an accredited investor because I have had individual
        income (exclusive of any income earned by my spouse) of more than
        $200,000 in each of the most recent two years and I reasonably expect to
        have an individual income in excess of $200,000 for the current year.
2._____ I certify that I am an accredited investor because I have had joint
        income with my spouse in excess of $300,000 in each of the most recent
        two years and reasonably expect to have joint income with my spouse in
        excess of $300,000 for the current year.
3._____ I certify that I am an accredited investor because I have an individual
        net worth, or my spouse and I have a joint net worth, in excess of
        $1,000,000.
4._____ I am a director or executive officer of Vyteris Holdings (Nevada), Inc.
5._____ I have individual net worth or my spouse and I have joint net worth of
        over $5,000,000.

B. PARTNERSHIPS, CORPORATIONS, TRUSTS OR OTHER ENTITIES: (Please INITIAL one of
   the following seven statements). The Lender hereby certifies that it is an
   accredited investor because it is:

1._____ an employee benefit plan whose total assets exceed $5,000,000;
2._____ an employee benefit plan whose investments decisions are made by a plan
        fiduciary which is either a bank, savings and loan association or an
        insurance company (as defined in Section 2(13) of the Securities Act) or
        an investment adviser registered as such under the Investment Advisers
        Act of 1940;
3._____ a self-directed employee benefit plan, including an Individual
        Retirement Account, with investment decisions made solely by persons
        that are accredited investors;
4._____ an organization described in Section 501(c)(3) of the Internal Revenue
        Code of 1986, as amended, not formed for the specific purpose of
        acquiring the Note, the Warrants and the Conversion Shares, with total
        assets in excess of $5,000,000;
5._____ a corporation, partnership or Massachusetts or similar business trust,
        with total assets in excess of $5,000,000, not formed for the specific
        purpose of acquiring the Note, the Warrants and the Conversion Shares
        and whose purchase is directed by a sophisticated person as described in
        Rule 506(b)(ii) of Regulation D and who has such knowledge and
        experience in financial and business matters that he is capable of
        evaluating the risks and merits of an investment in the Note, the
        Warrants and the Conversion Shares;
6._____ a trust, not formed for the specific purpose of acquiring the Note, the
        Warrants and the Conversion Shares, with total assets exceed $5,000,000,
        whose purchase is directed by a person who has such knowledge and
        experience in financial and business matters that he is capable of
        evaluating the merits and risks of an investment in the Note, the
        Warrants and the Conversion Shares; or
7._____ an entity (including a revocable grantor trust but other than a
        conventional trust) in which each of the equity owners qualifies as an
        accredited investor under items A(1), (2) or (3) or item B(1) above.

<PAGE>

                                     ANNEX A

                                  FORM OF NOTE

<PAGE>

                                     ANNEX B

                            FORM OF WARRANT AGREEMENT

<PAGE>

                                     ANNEX C

                           FORM OF SECURITY AGREEMENT

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