Document:

exv10w88

 

EXHIBIT
10.88

REVISED

EMPLOYMENT AGREEMENT

     This Revised Employment Agreement (this “Agreement”) is entered into as of December 27, 2005,
by and between Aastrom Biosciences, Inc., a Michigan corporation (“Employer”), and R. Douglas
Armstrong, Ph.D. (“Employee”).

RECITALS

     A. Employer and Employee are parties to that certain Employment Agreement dated as of August
27, 2004 (the “Prior Agreement”).

     B. Employer and Employee desire to make certain revisions, additions and deletions to the
terms of the Prior Agreement, as set forth in this Agreement.

     C. Employer and Employee intend that this Agreement shall supersede in the entirety of the
Prior Agreement, which Prior Agreement and any other written or oral employment and/or
benefits-related agreement, are hereby terminated in their entirety.

AGREEMENTS

     1. Definitions. As used in this Agreement, the following terms shall have the
following meanings:

          “Cause” means the occurrence of any of the following events, as determined by the
Board of Directors of Employer, in good faith:

          (i) Employee’s theft, material act of dishonesty or fraud, or intentional falsification of any
records of Employer;

          (ii) Employee’s breach of the Aastrom Biosciences, Inc. Restated Employee Proprietary
Information and Invention Agreement or any other agreement with the Employer covering the use or
disclosure of confidential or proprietary information of Employer, the ownership of intellectual
property or restrictions on competition;

          (iii) Employee’s gross negligence or willful misconduct in the performance of Employee’s
assigned duties (but not mere unsatisfactory performance); or

          (iv) Employee’s conviction (including any plea of guilty or nolo contendere) of a crime
causing material harm to the reputation or standing of Employer or which materially impairs
Employee’s ability to perform his duties for Employer.

          “Cessation Date” means the date when Employee ceases to be employed as the CEO of
Employer.

          “Change in Control” shall mean the occurrence of any of the following:

 

 

          (i) Employer is party to a merger or consolidation which results in the holders of voting
securities of Employer outstanding immediately prior thereto failing to continue to represent
(either by remaining outstanding or by being converted into voting securities of the surviving
entity) at least 50% of the combined voting power of the voting securities of Employer or such
surviving entity outstanding immediately after such merger or consolidation; or

          (ii) the sale or disposition of all or substantially all of Employer’s assets (or consummation
of any transaction having similar effect).

          “Code” means the Internal Revenue Code of 1986, as amended, and any successor thereto,
and any applicable regulations promulgated thereunder.

          “Disability” means that:

          (i) Employee has been incapacitated by bodily injury, illness or disease so as to be prevented
thereby from effectively performing Employee’s duties;

          (ii) Such incapacity shall have continued for a period of six (6) consecutive months; and

          (iii) Such incapacity will, in the opinion of a qualified physician, be long-term, which shall
mean a period exceeding twelve (12) months.

          “Employer” means Aastrom Biosciences, Inc., a Michigan corporation, and, following a
Change in Control, any Successor that agrees to assume all of the terms and provisions of this
Agreement, or a Successor which otherwise becomes bound by operation of law to this Agreement.

          “Incumbent Director” means a director who either (i) is a director of Employer as of
the Effective Date of this Agreement, or (ii) is elected, or nominated for election, to the Board
of Directors with the affirmative votes of at least a majority of the Incumbent Directors at the
time of such election or nomination.

          “Scheduled Termination Date” is defined in Section 5.3.

          “Subject Period” is defined in Section 9.1

          “Subject Line of Business” is defined in Section 9.1.

          “Successor” means Employer and any successor or assign to substantially all of its
business and/or assets.

     2. Employment. Employer hereby engages Employee, and Employee hereby accepts such
engagement, upon the terms and conditions set forth herein.

     3. Duties.

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          3.1 CEO. Employee is engaged as Chief Executive Officer (“CEO”). Employee shall
perform faithfully and diligently the duties customarily performed by persons in the position for
which employee is engaged, together with such other reasonable and appropriate duties as Employer
shall designate from time to time. Employee shall devote Employee’s full business time and efforts
to the rendition of such services and to the performance of such duties. As a full-time employee
of Employer, Employee shall not be entitled to provide consulting services or other business or
scientific services to any other party, without the prior written consent of Employer.

          3.2 Focus. Employee will focus his efforts primarily on fund raising, intellectual
property, and clinical trial matters for Employer’s business. Employee will also delegate certain
management duties to James Cour, the Chief Operating Officer of Employee, in consultation with
Employer’s Board of Directors.

          3.3 Board. Employee shall remain as Chairman of the Board of Directors of Employer
while he remains employed as CEO. Thereafter, it is the present intention of Employer’s Board and
Employee for Employee to continue as a member of the Board, subject to customary shareholder
meeting election schedule, and with other responsibilities (such as Chairman and committee
assignments) to be determined through customary Board processes.

     4. Compensation and Fringe Benefits.

          4.1 Base Salary. During the term of this Agreement, as compensation for the proper
and satisfactory performance of all duties to be performed by Employee hereunder, Employer shall
pay to Employee a base salary of Three Hundred Forty-Five Thousand and 00/100 Dollars ($345,000.00)
per year, payable in arrears in equal bi-weekly installments, less required deductions for state
and federal withholding tax, Social Security and all other employee taxes and payroll deductions.
The base salary shall be increased automatically as of July 1, 2006 to Three Hundred Fifty-Eight
Thousand and Eight Hundred Dollars ($358,800) per year.

          4.2 Bonus. Employee shall be eligible to receive equity and cash bonuses in
accordance with Employer’s customary incentive plans.

          4.3 Customary Fringe Benefits. Employee shall be entitled to such fringe benefits as
Employer customarily makes available to employees of Employer engaged in the same or similar
position as Employee (“Fringe Benefits”). Such Fringe Benefits may include vacation leave, sick
leave, and health insurance coverage, and 401(k) retirement contributions. Employer reserves the
right to change the Fringe Benefits on a prospective basis, at any time, effective upon delivery of
written notice to Employee.

          4.4 Disability Coverage. Employee shall be entitled to long-term disability insurance
coverage to the greatest extent available for purchase by the Employer.

          4.5 Vacation. Employee is entitled to twenty (20) days of vacation in each calendar
year.

          4.6 Accumulation. Employee shall earn and accumulate unused vacation and sick leave
in accordance with the Company’s policy in effect from time to time. Further,

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Employee shall not be entitled to receive payments in lieu of Fringe Benefits, other than for
unused vacation leave earned and accumulated at the time the employment relationship terminates.

          4.7 Board Compensation. While Employee remains employed and compensated as CEO,
Employee shall not receive any separate compensation for service on Employer’s Board of Directors.
After Employee ceases to be employed as CEO, and while Employee continues thereafter to serve as a
member of Employer’s Board of Directors, Employee shall be entitled to receive customary Director
compensation, the same as other non-employed Directors.

          4.8 Consulting Services. After Employee ceases to be employed as CEO, if Employer and
Employee mutually agree for Employee to perform specified consulting services (beyond the level of
services normal for a member of the Board of Directors), then the parties shall establish mutually
approved compensation corresponding to the nature, level and time commitment for such consulting
services; and the parties shall enter into a separate consulting agreement regarding the same.

     5. Term.

          5.1 Commencement. The employment relationship pursuant to this Agreement shall
commence on the date as of which this Agreement was executed as set forth above.

          5.2 Termination at Will. Employer and Employee acknowledge and agree that Employer’s
employment currently is “at will” and that their employment relationship may be terminated by
either party at any time, with or without Cause; and any such termination by Employer without Cause
will activate the payment provisions of Section 6.

          5.3 Scheduled Termination. The employment of Employee as Employer’s CEO shall
terminate on the earlier of (i) October 31, 2006, at 5:00 p.m., and (ii) the date when a new CEO of
Employer commences employment with Employer (the “Scheduled Termination Date”).

     6. Payments Upon Termination; Payments to Stay.

          6.1 Payment of Compensation Upon Termination.

               6.1.1 General. Upon termination of Employee’s employment with the Company, Employee
shall be entitled to be paid his base salary through the effective date of such termination, plus
the amounts (if any) determined pursuant to Sections 6.1.2, 6.2, 6.3, 6.4 and 7, as full
compensation for any and all claims of Employee under this Agreement.

               6.1.2 Early Termination. In the event the Scheduled Termination Date is prior to June
30, 2006, or if Employer terminates the employment without Cause prior to June 30, 2006, then
Employer shall nevertheless continue to pay to Employee through June 30, 2006 his base salary,
bonus and other compensation accrued through June 30, 2006.

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          6.2 Payment to Stay. In consideration for Employee committing to remain employed
full-time with Employer until the Scheduled Termination Date and conditional upon Employee
remaining available to serve as CEO until the Scheduled Termination Date, and in recognition of
Employee’s long-term service to Employer, Employer shall pay to Employee installment payments
aggregating to Six Hundred Thirty-Eight Thousand and Two Hundred Dollars ($638,200), payable as
follows:

                    a. $20,000 on the first day of July, August, September, and October 2006 (for an aggregate of
$80,000), and refundable if Employee does not remain available to serve as CEO until the Scheduled
Termination Date;

                    b. $30,000 on the first day of November and December 2006 (for an aggregate of $60,000);

                    c. $242,920 payable on January 4, 2007; and

                    d. $14,182.22 per month for the eighteen (18) months commencing with November 15, 2006, and
continuing monthly through April 15, 2008; and each such monthly payment shall be made on the 15th
of the month (for an aggregate of $255,280).

     For avoidance of doubt, the foregoing installment payments are in addition to the base salary
and bonus amounts payable to Employee for the time he serves as an employee, notwithstanding the
fact that some of these installment payments may be made while Employee is still an employee.

          6.3 Termination Without Cause. In the event Employee’s employment is terminated by
Employer without Cause prior to the Scheduled Termination Date, then Employer shall pay to Employee
the same sums as specified in Sections 6.1 and 6.2, on the same payment schedule.

          6.4 General.

               6.4.1 Payroll Taxes. Each of the foregoing payments shall be subject to required
customary payroll deductions.

               6.4.2 Death. If Employee dies prior to all of the foregoing payments being made, the
remaining payments shall be paid as scheduled to Employee’s wife (or estate, if Employee’s wife is
deceased).

               6.4.3 Continued Medical Coverage. In the event Employee’s employment is terminated,
then Employee shall be entitled to elect continued medical insurance coverage in accordance with
applicable provisions of the Consolidated Budget Reconciliation Act of 1985 (“COBRA”); and Employer
shall pay such COBRA insurance costs for the one year period after the Cessation Date, payable
according to such payment schedule as is required for such COBRA insurance.

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               6.4.4 Accrued Unused Vacation Time. Upon any termination of employment, Employer
shall pay to Employee, in accordance with Employer’s applicable policies, any accrued unused
vacation time, if any.

               6.4.5 Section 401(k) Contributions. The Section 401(k) contributions by Employer for
Employee’s account for 2006 shall become fully vested upon termination of employment, other than a
voluntary termination by Employee prior to the Scheduled Termination Date.

          6.5 Right to Terminate. Employer retains and reserves the right to terminate the
employment of Employee at any time, with or without Cause. For avoidance of doubt, the Section 6.2
payments shall not be owed if Employee’s employment is terminated by Employer for Cause, or if
Employee voluntarily terminates employment prior to the Scheduled Termination Date; and if the
Section 6.2 payments are not paid, then the Sections 9.1 and 9.2 covenants are not applicable.

          6.6 No Liability. No director, officer or shareholder of Employer shall have any
personal liability for the payment of any severance to Employee.

          6.7 Exclusive Remedy. The parties acknowledge and agree that the payments specified
in this Agreement constitute Employee’s sole and exclusive remedy for any alleged injury or other
damages arising out of a termination of Employee’s employment under circumstances described herein.
Accordingly, as a condition to said payments after a termination of employment, Employee shall
sign a customary and reasonable release form, in the form attached hereto as Exhibit A,
pursuant to which Employee acknowledges and agrees that Employee has no claims against Employer or
any director, officer, shareholder or agent of Employer, or any successor in interest to Employer,
with respect to any employment matters or termination of employment (excepting only for accrued
salary, accrued vacation leave and reimbursement of customary business expenses incurred on behalf
of Employer, all in the ordinary course of business, and the payments to which Employee is entitled
to receive pursuant to Sections 4, 6 and 7).

     7. Incentive Sale Bonus.

          7.1 General. In the event (i) Employer receives a term sheet, letter of intent or
agreement from an entity prior to May 1, 2008 for a Change in Control transaction, and (ii) such
term sheet, letter of intent or agreement forms the basis for a Change of Control transaction with
that entity (or its affiliate) which is ultimately consumated prior to May 1, 2009, then Employee
shall be entitled to participate in the incentive sale bonus pool (the “Bonus Pool”) described
below.

          7.2 Funding of Bonus Pool. The Bonus Pool shall be funded by a portion of the net
proceeds realized by Employer from a Change in Control, after all liabilities of Employer are
satisfied. Said net proceeds may consist of cash, stock or other consideration when and as paid by
the acquirer. The Bonus Pool shall be funded in increments consisting of 30% of the first million
of net proceeds, 25% of the second million of net proceeds, 15% of the third million

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of net proceeds, and 10% of all additional net proceeds up to an aggregate of $25 million of
net proceeds.

          7.3 Employee Share of Bonus Pool. Employee shall be entitled to a 50.0% share of the
Bonus Pool (which 50% share may be up to $1,450,000). Payment of this share will be made within
thirty (30) days after the Employer receives the specified net proceeds.

          7.4 Voluntary Termination by Employee. In the event that Employee voluntarily
terminates employment with Employer prior to the Scheduled Termination Date, then Employee shall
not be entitled to any share of the Bonus Pool. Alternatively, if Employer decides to terminate
Employee for reasons other than “Cause”, then Employee shall be entitled to receive Employee’s
designated share of the Bonus Pool if and when it becomes payable for a transaction as specified in
Section 7.1 above.

     8. Equity Vesting.

          8.1 Equity Vesting. Vesting for stock options and restricted stock grants held by
Employee shall be accelerated by one year at the Cessation Date. Following said one year, if and
to the extent that Employee continues to provide services to Employer as a Director or consultant,
then vesting will continue as specified in the applicable stock option agreements and restricted
stock agreements.

          8.2 No Amendments. Except as set forth in Section 8.1, this Agreement shall not be
deemed to modify the provisions of any stock options or restricted stock granted by Employer to
Employee on or before the date hereof.

9. Additional Covenants.

          9.1 Non-Competition. While Employee remains as an employee of Employer, and for a
period of 18 months thereafter, and plus any longer time period while employee continues as a
member of the Board of Directors or as a paid consultant of Employer (collectively called the
“Subject Period”), Employee agrees, in consideration of the payments set forth in Section 6.2, that
he will not, directly or indirectly, be employed by, provide services to, or have any business
connection with, any other corporation, firm, partnership or other entity which competes directly
with Employer’s business of “cultured stem cell products” (the “Business”). The companies “Osiris”
and Viacell are examples of presently existing companies which Employer and Employee mutually
acknowledge are currently engaged in the Business. Notwithstanding anything to the contrary, the
foregoing shall not preclude Employee after the Cessation Date from being engaged by (i) a large
company (e.g., Johnson & Johnson) which has some division, subsidiary or affiliate which is
involved with the Business, so long as Employee’s work for such large company is not related to the
Business (e.g., no reviews, analysis, evaluation, assessment, advice, etc. related to the
Business), or (ii) an investment company (such as an investment fund or an investment banker) which
has some investment and/or clients involved with the Business, so long as Employee’s work for such
investment company is not involved with the Business.

          9.2 Non-Solicitation of Employees. During the Subject Period, in consideration of the
payments set forth in Section 6.2, Employee agrees not to interfere with the

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business of Employer by soliciting, inducing, or otherwise causing any full-time employee of
Employer to terminate his/her employment with Employer, or to reduce his/her time commitment or
scope of services for Employer. The foregoing restriction shall apply to Employee regardless of
whether he is acting directly or indirectly, alone or in concert with others. The foregoing
restriction is not applicable to any former employee of Employer, after such person has ceased to
be an employee of Employer. For avoidance of doubt, the foregoing restriction shall not preclude
Employee, while Employee continues to serve as CEO of Employer, from Employee’s good faith exercise
of his management duties for the best interests of Employer, for terminating employees or changing
the scope of duties for employees.

          9.3 Confidential Information. Employee acknowledges that Employer has invested
substantial time, money and resources in the development and retention of Employer’s confidential
information and trade secrets (collectively called “Confidential Information”), and that during the
course of Employee’s employment with Employer, Employee has acquired knowledge of such Confidential
Information. So long as such Confidential Information remains confidential and not generally
available in the public domain, Employee hereby agrees to maintain the confidentiality of
Employer’s Confidential Information, and to not use any of such Confidential Information to the
detriment of Employer.

          9.4 General Cooperation. Following the Cessation Date, Employee shall cooperate
generally with Employer to provide relevant historical information known to Employee concerning
Employer’s past business activities. If significant amounts of time are needed for cooperation
requested Employer, Employer will pay reasonable compensation to be mutually approved by both
parties.

     10. General Provisions.

          10.1 Attorneys’ Fees. In the event of any dispute or breach arising with respect to
this Agreement, the party prevailing in any negotiations or proceedings for the resolution or
enforcement thereof shall be entitled to recover from the losing party reasonable expenses,
attorneys’ fees and costs incurred therein.

          10.2 Amendment. No amendment or modification of the terms or conditions of this
Agreement shall be valid unless in writing and signed by both parties hereto. There shall be no
implied-in-fact contracts modifying the terms of this Agreement. However, the noncumulation of
benefits provision of Section 10.6 shall apply to any subsequent agreement, unless (i) such
provision is explicitly disclaimed in the subsequent agreement, and (ii) the subsequent agreement
has been authorized by the Board or a committee thereof.

          10.3 Entire Agreement. This Agreement constitutes the entire agreement between the
parties with respect to the employment of Employee, other than relating to the Employer’s stock
option or restricted stock grants to Employee, and to Employer’s standard policies and agreements
regarding inventions, trade secrets, proprietary and confidential information, competition, and
solicitation of the Employer’s employees. This Agreement supersedes all prior agreements,
understandings, negotiations and representation with respect to the employment relationship. This
Agreement is not intended to and shall not affect, limit or

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terminate any plans, programs, or arrangements of Employer that are regularly made available
to a significant number of employees or officers of the Employer.

          10.4 Successors and Assigns.

               10.4.1 Successors of Employer. Employer shall require any Successor, expressly,
absolutely and unconditionally to assume and agree to perform this Agreement in the same manner and
to the same extent that Employer would be required to perform it if no such succession or
assignment had taken place. Failure of Employer to obtain such agreement shall be a material
breach of this Agreement.

               10.4.2 Heirs and Representatives of Employee. This Agreement shall inure to the
benefit of and be enforceable by the Employee’s personal and legal representatives, executors,
administrators, successors, heirs, distributees, devises and legatees.

          10.5 No Limitation of Regular Benefit Plans. This Agreement is not intended to and
shall not affect, limit or terminate any plans, programs, or arrangements of Employer that are
regularly made available to a significant number of employees or officers of Employer, including
without limitation Employer’s incentive compensation plans, 401(k) contribution plans, and stock
option and restricted stock plans.

          10.6 (Omitted).

          10.7 No Assignment of Benefits. The rights of any person to payments or benefits
under this Agreement shall not be made subject to option or assignment, either by voluntary or
involuntary assignment or by operation of law, including (without limitation) bankruptcy,
garnishment, attachment or other creditors process, and any action in violation of this Section
10.7 shall be void.

          10.8 Notices.

               10.8.1 General. Notices and all other communications contemplated by this Agreement
shall be in writing and shall be deemed to have been duly given when personally delivered, when
mailed, if mailed by U.S. registered or certified mail, return receipt requested and postage
prepaid, or when shipped, if shipped by nationally known reputable overnight delivery service and
shipping charges prepaid. In the case of Employee, notices shall be addressed to Employee at the
home address which he most recently communicated to the Employer, in writing. In the case of the
Employer, notices shall be addressed to its corporate headquarters, and all notices shall be
directed to the attention of its Secretary.

               10.8.2 Notice of Termination. Any termination by the Employer of Employee’s
employment for Cause or by Employee as a result of a voluntary resignation shall be communicated by
a notice of termination to the other party hereto given in accordance with Subsection 10.8.1. Such
notice shall indicate the specific termination provisions in this Agreement relied upon, shall set
forth in reasonable detail the facts and circumstances claimed to provide a basis for termination
under the provision so indicated, and shall specify the termination date.

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          10.9 No Duty to Mitigate. Employee shall not be required to mitigate the amount of
any payment contemplated by this Agreement (whether by seeking employment with a new employer or in
any other manner), nor shall any such payment be reduced by any earnings that Employee may receive
from any other source except as otherwise provided herein.

          10.10 No Representations. Employee acknowledges that in entering into this Agreement
Employee is not relying and has not relied on any promise, representation or statement made by or
on behalf of the Employer which is not set forth in this Agreement.

          10.11 Choice of Law. The validity, interpretation, construction and performance of
this Agreement shall be governed by the laws of the State of Michigan, without regard to its choice
of law rules.

          10.12 Waiver. Either party’s failure to enforce any provision of this Agreement shall
not in any way be construed as a waiver of any such provision, or prevent that party thereafter
from enforcing each and every other provision of this Agreement.

          10.13 Severable Provisions. The provisions of this Agreement are severable, and if
any one or more provisions may be determined to be judicially unenforceable, in whole or in part,
the remaining provisions shall nevertheless be binding and enforceable.

          10.14 Tax Withholding. The payments to be made pursuant to this Agreement will be
subject to customary withholding of applicable income and employment taxes.

          10.15 Consultation. Employee acknowledges that this Agreement confers significant
legal rights on Employee, and also involves Employee waiving other potential rights he might have
under other agreements and laws. Employee acknowledges that Employer has encouraged Employee to
consult with Employee’s own legal, tax, and financial advisers before signing the Agreement; and
that Employee has had adequate time to do so before signing this Agreement.

          10.16 Counterparts. This Agreement may be executed in counterparts, and each of which
shall be deemed an original, but all of which together will constitute one and the same instrument.

          10.17 Excess Parachute Payment. In the event that any payment or benefit received or
to be received by Employee pursuant to this Agreement or otherwise would subject Employee to any
excise tax pursuant to Section 4999 of the Code due to the characterization of such payment or
benefit as an excess parachute payment under Section 280G of the Code, Employee may elect in his
sole discretion to reduce the amounts of any payments or benefits otherwise called for under this
Agreement in order to avoid such characterization.

          10.18 (Omitted).

          10.19 Arbitration. Either party to this Agreement may submit any dispute under this
Agreement for binding arbitration of the dispute before an arbitrator mutually acceptable to both
parties, the arbitration to be held in Ann Arbor, Michigan, in accordance with the arbitration
rules of the American Arbitration Association, as then in effect. If the parties are

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unable to mutually agree upon an arbitrator, then the arbitration proceedings shall be held
before three arbitrators, one of which shall be designated by the Employer, one of which shall be
designated by the claimant and the third of which shall be designated mutually by the first two
arbitrators in accordance with the arbitration rules referenced above. The arbitrator(s) sole
authority shall be to interpret and apply the provisions of this Agreement; the arbitrator(s) shall
not change, add to, or subtract from, any of the Agreement’s provisions. The arbitrator(s) shall
have the power to compel attendance of witnesses at the hearing. Any court having jurisdiction may
enter a judgment based upon such arbitration. The decision of the arbitrator(s) shall be final and
binding on the parties to this Agreement and without appeal to any court. Upon execution of this
Agreement, the Employee shall be deemed to have waived any right to commence litigation proceedings
regarding this Agreement outside of arbitration without the express written consent of the
Employer.

          10.20 Reporting and Disclosure. The Employer, from time to time, shall provide
government agencies with such reports concerning this Agreement as may be required by law, and the
Employer shall provide the Employee with such disclosure concerning this Agreement as may be
required by law or as the Employer may deem appropriate.

     11. Employee’s Representations. Employee represents and warrants that Employee (i) is
free to enter into this Agreement and to perform each of the terms and covenants contained herein,
(ii) is not restricted or prohibited, contractually or otherwise, from entering into and performing
this Agreement, and (iii) will not be in violation or breach of any other agreement by reason of
Employee’s execution and performance of this Agreement.

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date set forth above.

	 	 	 	 	 	 	 
	 	 	EMPLOYER:	 	 
	 
	 	 	 	 	 	 
	 	 	Aastrom Biosciences, Inc.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

	 	 

	 	 	 	 	 	 	 
	 	 	EMPLOYEE:	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	R. Douglas Armstrong, Ph.D.	 	 
	 
	 	 	 	 	 	 
	 

	 	Address:
	 	5330 Falkirk Court	 	 
	 

	 	 	 	Superior, MI 48198	 	 

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EXHIBIT A

FORM OF RELEASE

RELEASE AGREEMENT

     THIS AGREEMENT (this “Agreement”) is made by and between R. Douglas Armstrong, Ph.D.
(“Executive”) and Aastrom Biosciences, Inc. (“Company”).

RECITALS

     A. Executive’s employment as an executive officer of Company, is to terminate effective , 2006
(the “Effective Date”).

     B. Executive has been given the opportunity to review this Agreement, to consult with legal
counsel, and to ascertain his rights and remedies.

     C. Executive and Company, without any admission of liability, desire to settle with finality,
compromise, dispose of, and release any and all claims and demands asserted or which could be
asserted arising out of Executive’s employment at and separation from Company.

     In consideration of the foregoing and of the promises and mutual covenants contained herein,
it is hereby agreed between Executive and Company as follows:

AGREEMENT

     1. Release. In exchange for the good and valuable consideration set forth in that
certain Employment Agreement, made as of December ___, 2005, between the Company and Executive
(the “Employment Agreement”), and conditional upon Company making the payments as required by the
Employment Agreement, Executive hereby releases, waives and discharges any and all manner of
action, causes of action, claims, rights, charges, suits, damages, debts, demands, obligations,
attorneys fees, and any and all other liabilities or claims of whatsoever nature, whether in law or
in equity, known or unknown, including, but not limited to, age discrimination under The Age
Discrimination In Employment Act of 1967 (as amended), employment discrimination prohibited by
other federal, state or local laws, and any other claims, which Executive has claimed or may claim
or could claim in any local, state or federal or other forum, against Company, its directors,
officers, employees, agents, attorneys, successors and assigns as a result of or relating to
Executive’s employment at and separation from Company and as an officer of Company as a result of
any acts or omissions by Company or any of its directors, officers, employees, agents, attorneys,
successors or assigns (“Covered Acts or Omissions”) which occurred prior to the date of this
Agreement; excluding only (i) those to compel the payment of amounts due to Executive as
provided in the Employment Agreement, (ii) enforcement of any rights of Executive under any stock
option or restricted stock agreements with the Company or (iii) those for indemnification under the
Company’s articles of

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incorporation, bylaws or applicable law by reason of his service as an officer or director of the
Company.

     2. Return of Company Property. Executive agrees to immediately return to Company all
property, assets, manuals, materials, information, notes, reports, agreements, memoranda, customer
lists, formulae, data, know-how, inventions, trade secrets, processes, techniques, and all other
assets, materials and information of any kind or nature, belonging or pertaining to Company
(“Company Information and Property”), including, but not limited to, computer programs and
diskettes or other media for electronic storage of information containing Company Information and
Property, in Executive’s possession, and Executive shall not retain copies of any such Company
Information and Property. Executive further agrees that from and after the date hereof he will not
remove from Company’s offices any Company Information and Property, nor retain possession or copies
of any Company Information and Property. Notwithstanding the foregoing, Employee shall be entitled
to retain (i) any non-confidential materials, and (ii) the electronic equipment which he uses as of
the Cessation Date (i.e., personal lap top computer, home computers, printer, palm pilot, cell
phone), to be itemized at the Cessation Date; but all confidential information shall be deleted
from such equipment – other than information which Employer elects may remain so as to facilitate
Employee’s subsequent services as a Director and/or consultant.

     3. No Derogative Statements. Executive agrees that he shall never make any statement
that negatively affects the goodwill or good reputation of the Company, or any officer or director
of Company, except as required by law, and except that such statements may be made to members of
the Board of Directors of the Company.

     4. No Covered Litigation. Executive covenants and agrees that he shall never commence
or prosecute, or knowingly encourage, promote, assist or participate in any way, except as required
by law, in the commencement or prosecution, of any claim, demand, action, cause of action or suit
of any nature whatsoever against Company or any officer, director, employee or agent of Company
(“Covered Litigation”) that is based upon any claim, demand, action, cause of action or suit
released pursuant to this Agreement or involving or based upon the Covered Acts and Omissions.

     5. Reading. Executive further agrees that he has read this Agreement carefully and
understands all of its terms.

     6. Understanding. Executive understands and agrees that he was advised to consult
with an attorney and did so prior to executing this Agreement.

     7. Timing. Executive understands and agrees that he has been given twenty-one (21)
days within which to consider this Agreement.

     8. Revocation Right. Executive understands and agrees that he may revoke this
Agreement for a period of seven (7) calendar days following the execution of this Agreement (the
“Revocation Period”). This Agreement is not effective until this revocation period has expired.
Executive understands that any revocation, to be effective, must be in writing and either (a)
postmarked within seven (7) days of execution of this Agreement and addressed to Aastrom

13

 

Biosciences, Inc., 24 Frank Lloyd Drive, Ann Arbor, Michigan 48105 or (b) hand delivered within
seven (7) days after execution of this Agreement to Aastrom Biosciences, Inc., 24 Frank Lloyd
Drive, Ann Arbor, Michigan 48105. Executive understands that if revocation is made by mail, mailing
by certified mail, return receipt requested, is recommended to show proof of mailing.

     9. Voluntary Signing. In agreeing to sign this Agreement and separate from Company,
Executive is doing so completely voluntarily and of his own free-will and without any encouragement
or pressure from Company and agrees that in doing so he has not relied on any oral statements or
explanations made by Company or its representatives.

     10. Confidentiality. Both parties agree not to disclose the terms of this Agreement
to any third party, except as is required by law, or as is necessary for purposes of securing
counsel from either parties’ attorneys or accountants.

     11. No Admissions. This Agreement shall not be construed as an admission of
wrongdoing by Company.

     12. Entirety; Amendment. This Agreement contains the entire agreement between
Executive and Company regarding the matters set forth herein. Any modification of this Agreement
must be made in writing and signed by Executive and each of the entities constituting the Company.

     13. Michigan Law. This Agreement shall be governed by and construed in accordance
with the domestic laws of the State of Michigan, without giving effect to any choice of law or
conflict of law provision or rule (whether of the State of Michigan or any other jurisdiction) that
would cause the application of the laws of any jurisdiction other than the State of Michigan.

     14. Invalidity. In the event any provision of this Agreement or portion thereof is
found to be wholly or partially invalid, illegal or unenforceable in any judicial proceeding, then
such provision shall be deemed to be modified or restricted to the extent and in the manner
necessary to render the same valid and enforceable, or shall be deemed excised from this Agreement,
as the case may require, and this Agreement shall be construed and enforced to the maximum extent
permitted by law, as if such provision had been originally incorporated herein as so modified or
restricted, or as if such provision had not been originally incorporated herein, as the case may
be.

     15. Remedies. If there is a breach or threatened breach of the provisions of this
Agreement, Company may, in addition to other available rights and remedies, apply to any court of
competent jurisdiction for specific performance and/or injunctive relief in order to enforce, or
prevent any violation of, any of the provisions of this Agreement.

     16. Offset. In the event that Executive violates the terms of this Agreement, in
addition to other available rights and remedies, the Company shall be entitled to an offset against
any payments remaining owed under the Employment Agreement in an amount equal to any damages caused
to Company as a result of such violations.

14

 

     The parties hereto have entered into this Agreement as of the Effective Date set froth above.

	 	 	 	 	 
	COMPANY:	 	 
	 
	 	 	 	 
	AASTROM BIOSCIENCES, INC.	 	 
	 
	 	 	 	 
	By:
	 	 	 	 
	 

	 	 

	 	 
	 
	 	 	 	 
	EXECUTIVE:	 	 
	 
	 	 	 	 
	 	 	 
	R. Douglas Armstrong, Ph.D.	 	 

15exv10w89

 

EXHIBIT
10.89

AMENDED AND RESTATED

EMPLOYMENT AGREEMENT

     This
Amended and Restated Employment Agreement (the “Agreement”)
is entered into as of January 12, 2006, by and between Aastrom Biosciences, Inc., a Michigan corporation (“Employer”), and
James A. Cour (“Employee”).

RECITALS

     A. Employer and Employee are parties to that certain Employment Agreement entered into as of
June 11, 2004 (the “Existing Employment Agreement”).

     B. Employer and Employee are also parties to certain other written employment and/or
benefits-related agreements as follows: (i) Relocation Expenses Reimbursement Agreement
(collectively, the “Other Agreements”).

     C. Employer and Employee desire to amend and restate the Existing Employment Agreement to
incorporate into a single document the terms and conditions of the Existing Employment Agreement
and the Other Agreements as set forth herein.

     D. Employer and Employee intend that this Agreement shall supersede in their entirety the
Existing Employment Agreement and the Other Agreements, which Existing Employment Agreement and
Other Agreements are, by this Agreement, hereby terminated in their entirety.

AGREEMENTS

     1. Definitions. As used in this Agreement, the following terms shall have the following
meanings:

          “Acquiring Corporation” shall mean the surviving, successor or purchasing corporation
or parent corporation thereof, in a Change in Control, as the case may be.

          “Cause” means the occurrence of any of the following events, as determined by the
Board of Directors of Employer, in good faith:

          (i) Employee’s theft, material act of dishonesty or fraud, or intentional falsification of any
records of Employer;

          (ii) Employee’s breach of the Aastrom Biosciences, Inc. Employee Proprietary Information and
Invention Agreement or any other agreement with the Employer covering the use or disclosure of
confidential or proprietary information of Employer, the ownership of intellectual property or
restrictions on competition;

          (iii) Employee’s gross negligence or willful misconduct in the performance of Employee’s
assigned duties (but not mere unsatisfactory performance); or

 

 

          (iv) Employee’s conviction (including any plea of guilty or nolo contendere) of a crime
causing material harm to the reputation or standing of Employer or which materially impairs
Employee’s ability to perform his duties for Employer.

          “Change in Control” shall mean the occurrence of any of the following:

          (i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange
Act of 1934, as amended (the “Exchange Act”)), other than a trustee or other fiduciary holding
securities of Employer under an employee benefit plan of Employer, becomes the “beneficial owner”
(as defined in Rule 13d-3 promulgated under the Exchange Act), directly or indirectly, of
securities of Employer representing 50% or more of (A) the outstanding shares of common stock of
Employer or (B) the combined voting power of Employer’s then-outstanding securities;

          (ii) Employer is party to a merger or consolidation which results in the holders of voting
securities of Employer outstanding immediately prior thereto failing to continue to represent
(either by remaining outstanding or by being converted into voting securities of the surviving
entity) at least 50% of the combined voting power of the voting securities of Employer or such
surviving entity outstanding immediately after such merger or consolidation; or

          (iii) the sale or disposition of all or substantially all of Employer’s assets (or
consummation of any transaction having similar effect).

          “Current Residence” shall mean the Employee’s residence in Illinois as of June 2004.

          “Disability” means that:

          (i) Employee has been incapacitated by bodily injury, illness or disease so as to be prevented
thereby from effectively performing Employee’s duties;

          (ii) Such incapacity shall have continued for a period of six (6) consecutive months; and

          (iii) Such incapacity will, in the opinion of a qualified physician, be long-term, which shall
mean a period exceeding twelve (12) months.

          “Employer” means Aastrom Biosciences, Inc., a Michigan corporation, and, following a
Change in Control, any Successor that agrees to assume all of the terms and provisions of this
Agreement, or a Successor which otherwise becomes bound by operation of law to this Agreement.

          “Good Reason” means the occurrence of any of the following conditions following a
Change in Control, without Employee’s informed written consent, which condition(s) remain(s) in
effect ten (10) days after written notice to Employer from Employee of such condition(s):

2

 

          (i) assignment of Employee to responsibilities or duties that are not a Substantive Functional
Equivalent of the position which Employee occupied prior to the Change in Control;

          (ii) any decrease in Employee’s base salary or target bonus amount (subject to applicable
performance requirements with respect to the actual amount of bonus compensation earned by
Employee);

          (iii) any failure by Employer to (A) continue to provide Employee with the opportunity to
participate, on terms no less favorable than those in effect for the benefit of any employee group
which customarily includes a person holding the employment position or a comparable position with
Employer then held by Employee, in any benefit or compensation plans and programs, including, but
not limited to, Employer’s life, disability, health, dental, medical, savings, profit sharing,
stock purchase and retirement plans, if any, in which Employee was participating immediately prior
to the date of the Change in Control, or their equivalent, or (B) provide Employee with all other
fringe benefits (or their equivalent) from time to time in effect for the benefit of any employee
group which customarily includes a person holding the employment position or a comparable position
with Employer then held by Employee;

          (iv) the relocation of Employee’s work place for Employer to a location more than 50 miles
from the location of the work place prior to the Change in Control, or the imposition of travel
requirements substantially more demanding of Employee than such travel requirements existing
immediately prior to the Change in Control; or

          (v) any material breach of this Agreement by Employer.

          “New Residence” shall mean the Employee’s new principal residence located within fifty
(50) miles of Ann Arbor, Michigan.

          “Relocation Costs” shall mean the following actual out-of-pocket costs incurred by the
Employee:

          (i) Coach class airfare for Employee’s family to move from Employee’s Current Residence to Ann
Arbor, Michigan, or, in the alternative, reimbursement of reasonable automobile operating costs
(gas, tolls, etc.), not to exceed the current IRS permitted per mile allowances, for up to two
automobiles required to move the Employee’s family.

          (ii) Cost for packing, shipping, and unloading personal household furnishings and belongings
from Employee’s Current Residence to his New Residence, including temporary storage as needed.

          (iii) Shipment of one personal vehicle from Illinois to Ann Arbor, Michigan, via common
carrier.

          (iv) All real estate sales commissions paid by Employee on the sale of his Current Residence,
up to 6% of the gross proceeds realized by the Employee from such sale.

3

 

          (v) Usual, customary and reasonable closing costs incurred by Employee in connection with the
sale of his Current Residence if typically paid by the seller. Closing costs shall be defined as
transfer taxes, documentary stamp taxes, title insurance premiums, recording charges, appraisals,
inspections, attorneys fees, surveys, escrow fees and such other usual, customary and reasonable
closing costs as are specifically approved by the Chairman and Chief Executive Officer of Employer.
Closing Costs shall not include payments required at closing for real property taxes or
assessments, or proration of utilities or other prepaid expenses.

          (vi) Coordination services to be provided by Prudential Relocation Management, or an
equivalent service provider.

          (vii) Usual, customary and reasonable closing costs incurred by Employee in connection with
the purchase of a New Residence if typically paid by the buyer. Closing costs shall be defined as
inspections, attorney fees, mortgage application fees, recording fees and such other usual,
customary and reasonable closing costs as are specifically approved by the Chairman and Chief
Executive Officer of the Employer. Closing Costs shall not include payments required at closing
for real property taxes or assessments, proration of utilities or other prepaid expenses, real
estate sales commissions or mortgage points.

          (viii) The aggregate of all of the above-described costs shall not exceed $75,000.00 without
prior written agreement of Employer.

          “Substantive Functional Equivalent” means an employment position occupied by Employee
after a Change in Control that:

          (i) is in a substantive area of competence consistent with Employee’s experience and not
materially different from the position occupied by Employee prior to the Change in Control;

          (ii) requires Employee to serve in a role and perform duties that are functionally equivalent
to those performed prior to the Change in Control (such as, executive officer);

          (iii) carries a title that does not connote a lesser rank or corporate role than the title
held by Employee prior to the Change in Control; and

          (iv) does not otherwise constitute a material, adverse change in Employee’s responsibilities
or duties, as measured against Employee’s responsibilities or duties prior to the Change in
Control, causing it to be of materially lesser rank or responsibility.

          “Successor” means Employer and any successor or assign to substantially all of its
business and/or assets.

     2. Employment. Employer hereby engages Employee, and Employee hereby accepts such engagement,
upon the terms and conditions set forth herein.

     3. Duties. Employee is engaged as President and Chief Operating Officer. Employee shall
perform faithfully and diligently the duties customarily performed by persons in

4

 

the position for which employee is engaged, together with such other reasonable and
appropriate duties as Employer shall designate from time to time. Employee shall devote Employee’s
full business time and efforts to the rendition of such services and to the performance of such
duties. As a full-time employee of Employer, Employee shall not be entitled to provide consulting
services or other business or scientific services to any other party, without the prior written
consent of Employer.

     4. Compensation and Fringe Benefits.

     4.1 Base Salary. During the term of this Agreement, as compensation for the proper and
satisfactory performance of all duties to be performed by Employee hereunder, Employer shall pay to
Employee a salary of Two Hundred Sixty Thousand and 00/100 Dollars ($260,000.00) per year,
increased to Two Hundred Seventy Two Thousand Five Hundred and 00/100 Dollars ($272,500) per year
effective as of July 1, 2005, payable in arrears in equal semi-monthly installments, less required
deductions for state and federal withholding tax, Social Security and all other employee taxes and
payroll deductions. The base salary shall be subject to review and adjustment on an annual basis.

     4.2 Customary Fringe Benefits. Employee shall be entitled to such fringe benefits as Employer
customarily makes available to employees of Employer engaged in the same or similar position as
Employee (“Fringe Benefits”). Such Fringe Benefits may include vacation leave, sick leave, and
health insurance coverage. Employer reserves the right to change the Fringe Benefits on a
prospective basis, at any time, effective upon delivery of written notice to Employee.

     4.3 Vacation. Employee is entitled to twenty (20) days of vacation in each calendar year.

     4.4 Accumulation. Employee shall earn and accumulate unused vacation and sick leave in
accordance with the Company’s policy in effect from time to time. Further, Employee shall not be
entitled to receive payments in lieu of Fringe Benefits, other than for unused vacation leave
earned and accumulated at the time the employment relationship terminates.

     4.5 Relocation Costs.

          4.5.1 Temporary Housing. Employee agrees to relocate his principal domestic residence to
within fifty (50) miles of Ann Arbor, Michigan by January 1, 2005. Employee shall promptly offer
his Current Residence for sale through Prudential Relocation Management. Until Employee purchases
a new home in the Ann Arbor, Michigan area, but in no event later than January 1, 2005, Employer
shall provide Employee (and, beginning August 10, 2004 if Employee’s Current Residence has not been
sold by such date, Employee’s immediate family) furnished, temporary housing in the Ann Arbor,
Michigan area or, at Employer’s option, reimburse the Employee for Employee’s actual out-of-pocket
cost to obtain furnished, temporary housing in the Ann Arbor, Michigan area.

          4.5.2 Relocation Costs. Employer shall pay for the Relocation Costs either through payments
to Prudential Relocation Management or by direct reimbursement of Employee upon presentation of
appropriate invoices and/or receipts for the expenditures and

5

 

expenses for the Relocation Costs. The Employee shall be required to refund and pay to
Employer 100% of the Relocation Costs that have been paid by the Employer on the following terms:

          (i) If Employee’s employment with Employer ceases within 18 months after Employee commences
full-time employment with Employer (the “Commencement Date”), due to the Employee voluntarily
electing to leave the employ of Employer, or Employer terminating the Employee for Cause, Employee
hereby agrees to refund and pay to Employer 100% of the Relocation Costs that have been paid by
Employer.

          (ii) If Employer elects to terminate the employment of Employee without Cause, then Employee
shall have no obligation to refund any of the Relocation Costs. If Employee’s employment
terminates due to Employee’s death or disability, then Employee shall have no obligation to refund
any of the Relocation Costs.

          (iii) With respect to any of the Relocation Costs which Employee does become obligated to
refund to Employer, as specified above, said refund shall be made within six months after the
termination of employment. Any portion of the Relocation Costs which are obligated to be refunded
by Employee, and which are not refunded within said six (6) months, shall thereafter bear a late
payment charge of 10% per annum.

     5. Term.

     5.1 Commencement Date. The employment relationship pursuant to this Agreement shall commence
on July 6, 2005. For purposes of Section 4.5.2 the Commencement Date shall be July 5, 2004.

     5.2 Termination at Will. Employer and Employee acknowledge and agree that Employer’s
employment currently is “at will” and that their employment relationship may be terminated by
either party at any time, with or without Cause.

     6. Payments Upon Termination.

     6.1 Payment of Compensation Upon Termination. Upon termination of Employee’s employment with
the Company, Employee shall be entitled to be paid his base salary through the effective date of
such termination, as full compensation for any and all claims of Employee under this Agreement or
otherwise, except as set forth in Section 6.2.

     6.2 Payment of Severance Upon Termination.

     6.2.1 Severance. In the event Employee’s employment is terminated by Employer without Cause,
or in the event of Employee’s termination of his employment for Good Reason within twelve (12)
months following a Change in Control, then Employer shall pay to Employee severance payment equal
to nine (9) months of Employee’s then current salary rate, less customary payroll deductions. The
severance payment shall be paid in equal installments over nine (9) months in accordance with the
Employer’s normal payroll periods, except that severance payments due following a Change in Control
shall be paid in a lump sum immediately following the Change in Control.

6

 

     6.2.2 Continued Medical Coverage. In the event Employee’s employment is terminated, then
Employee shall be entitled to elect continued medical insurance coverage in accordance with
applicable provisions of the Consolidated Budget Reconciliation Act of 1985 (“COBRA”).

     6.2.3 Right to Terminate. Employer retains and reserves the right to terminate the employment
of Employee at any time, with or without Cause. For avoidance of doubt, said severance payment
shall not be owed if Employee’s termination is for Cause, if Employee voluntarily terminates
employment for reasons other than as specified in Section 6.2.1 hereof or if Employee’s employment
terminates as a result of Employee’s death or disability.

     6.2.4 No Liability. No director, officer or shareholder of Employer shall have any personal
liability for the payment of any severance to Employee.

     6.3 Resignation. Employee’s entitlement to any compensation or benefits under this Section 6
(other than compensation and benefits earned by Employee through the date of Employee’s termination
of employment) is conditioned upon Employee’s resignation from all capacities in which Employee is
then rendering services to Employer, including from the Board of Directors and any committees
thereof on which Employee serves.

     6.4 Exclusive Remedy. The parties acknowledge and agree that the payments specified herein
constitute Employee’s sole and exclusive remedy for any alleged injury or other damages arising out
of a termination of Employee’s employment under circumstances described herein. Accordingly, as a
condition to receipt of said payments, Employee shall sign a customary and reasonable release form,
in the form attached hereto as Exhibit A, pursuant to which Employee acknowledges and
agrees that Employee has no claims against Employer or any director, officer, shareholder or agent
of Employer, or any successor in interest to Employer, with respect to any employment matters or
termination of employment (excepting only for accrued salary, accrued vacation leave and
reimbursement of customary business expenses incurred on behalf of Employer, all in the ordinary
course of business, or any incentive sale bonus to which Employee may be entitled, if any).

     7. General Provisions.

     7.1 Attorneys’ Fees. In the event of any dispute or breach arising with respect to this
Agreement, the party prevailing in any negotiations or proceedings for the resolution or
enforcement thereof shall be entitled to recover from the losing party reasonable expenses,
attorneys’ fees and costs incurred therein.

     7.2 Amendments. No amendment or modification of the terms or conditions of this Agreement
shall be valid unless in writing and signed by both parties hereto. There shall be no
implied-in-fact contracts modifying the terms of this Agreement. However, the noncumulation of
benefits provision of Section 7.6 shall apply to any subsequent agreement, unless (i) such
provision is explicitly disclaimed in the subsequent agreement, and (ii) the subsequent agreement
has been authorized by the Board of Directors of the Employer or a committee thereof.

     7.3 Entire Agreement. This Agreement constitutes the entire agreement between the parties
with respect to the employment of Employee, other than relating to the Employer’s stock

7

 

option grants to Employee, the Employer’s inventions, trade secrets, and proprietary and
confidential information, competition with the Employer and solicitation of the Employer’s
employees. This Agreement supersedes all prior agreements, understandings, negotiations and
representation with respect to the employment relationship, including, without limitation, the
Existing Employment Agreement and the Other Agreements, each of which is hereby terminated in its
entirety.

     7.4 Successors and Assigns. This Agreement shall inure to the benefit of and be enforceable
by the Employee’s personal and legal representatives, executors, administrators, successors, heirs,
distributees, devises and legatees.

     7.5 No Limitation of Regular Benefit Plans. This Agreement is not intended to and shall not
affect, limit or terminate any plans, programs, or arrangements of Employer that are regularly made
available to a significant number of employees or officers of the Employer, including without
limitation Employer’s stock option plans.

     7.6 Noncumulation of Benefits. Employee may not cumulate cash severance payments under both
this Agreement and another agreement. If Employee has any other binding written agreement with
Employer which provides that, upon a Change in Control or termination of employment, Employee shall
receive one or more of the benefits described in Sections 6 of this Agreement (i.e., the payment of
cash compensation), then with respect to those benefits the aggregate amounts payable under this
Agreement shall be reduced by the amounts paid or payable under such other agreements.

     7.7 No Assignment of Benefits. The rights of any person to payments or benefits under this
Agreement shall not be made subject to option or assignment, either by voluntary or involuntary
assignment or by operation of law, including (without limitation) bankruptcy, garnishment,
attachment or other creditors process, and any action in violation of this Section 7.7 shall be
void.

     7.8 Notices. Notices and all other communications contemplated by this Agreement shall be in
writing and shall be deemed to have been duly given when personally delivered, when mailed, if
mailed by U.S. registered or certified mail, return receipt requested and postage prepaid, or when
shipped, if shipped by nationally known reputable overnight delivery service and shipping charges
prepaid. In the case of Employee, notices shall be addressed to Employee at the home address which
he most recently communicated to the Employer, in writing. In the case of the Employer, notices
shall be addressed to its corporate headquarters, and all notices shall be directed to the
attention of its Secretary.

     7.9 No Duty to Mitigate. Employee shall not be required to mitigate the amount of any payment
contemplated by this Agreement (whether by seeking employment with a new employer or in any other
manner), nor shall any such payment be reduced by any earnings that Employee may receive from any
other source except as otherwise provided herein.

     7.10 No Representations. Employee acknowledges that in entering into this Agreement Employee
is not relying and has not relied on any promise, representation or statement made by or on behalf
of the Employer which is not set forth in this Agreement.

8

 

     7.11 Choice of Law. The validity, interpretation, construction and performance of this
Agreement shall be governed by the laws of the State of Michigan, without regard to its choice of
law rules.

     7.12 Waiver. Either party’s failure to enforce any provision of this Agreement shall not in
any way be construed as a waiver of any such provision, or prevent that party thereafter from
enforcing each and every other provision of this Agreement.

     7.13 Severable Provisions. The provisions of this Agreement are severable, and if any one or
more provisions may be determined to be judicially unenforceable, in whole or in part, the
remaining provisions shall nevertheless be binding and enforceable.

     7.14 Tax Withholding. The payments to be made pursuant to this Agreement will be subject to
customary withholding of applicable income and employment taxes.

     7.15 Consultation. Employee acknowledges that this Agreement confers significant legal rights
on Employee, and also involves Employee waiving other potential rights he might have under other
agreements and laws. Employee acknowledges that Employer has encouraged Employee to consult with
Employee’s own legal, tax, and financial advisers before signing the Agreement; and that Employee
has had adequate time to do so before signing this Agreement.

     7.16 Counterparts. This Agreement may be executed in counterparts, and each of which shall be
deemed an original, but all of which together will constitute one and the same instrument.

     7.17 Excess Parachute Payment. In the event that any payment or benefit received or to be
received by Employee pursuant to this Agreement or otherwise would subject Employee to any excise
tax pursuant to Section 4999 of the Code due to the characterization of such payment or benefit as
an excess parachute payment under Section 280G of the Code, Employee may elect in his sole
discretion to reduce the amounts of any payments or benefits otherwise called for under this
Agreement in order to avoid such characterization.

     7.18 Claims Procedure for Severance Payments.

          7.18.1 Administrator. The administrator for purposes of the severance payments provided by
Section 6.2 of this Agreement shall be the Employer (“Administrator”), whose address is 24 Frank
Lloyd Wright Dr., P.O. Box 376, Ann Arbor, Michigan 48106, and whose telephone number is
734-930-5555. The “Named Fiduciary” as defined in Section 402(a)(2) of ERISA, also shall be the
Employer. The Employer shall have the right to designate one or more employees as the
Administrator and the Named Fiduciary at any time, and to change the address and telephone number
of the same. The Employer shall give the Employee written notice of any change in the
Administrator and Named Fiduciary, or in the address or telephone number of the same.

          7.18.2 Claims. The Administrator shall make all determinations as to the right of any person
to receive benefits under this Agreement. Any denial by the Administrator of a claim for benefits
by the Employee (“the claimant”) shall be stated in writing by the Administrator and delivered or
mailed to the claimant within ten (10) days after receipt of the claim, unless special

9

 

circumstances require an extension of time for processing the claim. If such an extension is
required, written notice of the extension shall be furnished to the claimant prior to the
termination of the initial 10-day period. In no event shall such extension exceed a period of ten
(10) days from the end of the initial period. Any notice of denial shall set forth the specific
reasons for the denial, specific reference to pertinent provisions of this Agreement upon which the
denial is based, a description of any additional material or information necessary for the claimant
to perfect the claim, with an explanation of why such material or information is necessary, and any
explanation of claim review procedures, and the time limits applicable to such procedures,
including a statement of the claimant’s right to bring a civil action under ERISA Section 502(a)
after exhausting all levels of appeal provided herein, written to the best of the Administrator’s
ability in a manner that may be understood without legal or actuarial counsel.

          7.18.3 Review of Claim Denial. A claimant whose claim for benefits has been wholly or
partially denied by the Administrator may request, within sixty (60) days following the date of
such denial, in a writing addressed to the Administrator, a review of such denial. The claimant
shall be entitled to submit such issues or comments in writing or otherwise, as the claimant shall
consider relevant to a determination of the claim, and the claimant may include a request for a
hearing in person before the Administrator. Prior to submitting the request, the claimant shall be
entitled to review such documents as are relevant to the claim. The claimant may, at all stages of
review, be represented by counsel, legal or otherwise, of the claimant’s choice. All requests for
review shall be promptly resolved. The Administrator’s decision with respect to any such review
shall be set forth in writing and shall be mailed to the claimant not later than ten (10) days
following receipt by the Administrator of the claimant’s request unless special circumstances, such
as the need to hold a hearing, require an extension of time for processing, in which case the
Administrator’s decision shall be so mailed not later than twenty (20) days after receipt of such
request.

          7.18.4 Arbitration. A claimant who has followed the procedure in paragraphs 7.18.2 and 7.18.3
of this Section, but who has not obtained full relief on the claim for benefits, may, within sixty
(60) days following the claimant’s receipt of the Administrator’s written decision on review, apply
in writing to the Administrator for arbitration of the claim as provided in Section 7.19.

     7.19 Arbitration.

          (a) Either party to this Agreement, after complying with the requirements of Section 7.18, to
the extent applicable, may submit any dispute under this Agreement for binding arbitration of the
dispute before an arbitrator mutually acceptable to both parties, the arbitration to be held in Ann
Arbor, Michigan, in accordance with the arbitration rules of the American Arbitration Association,
as then in effect, and the rights of claimant under Section 7.18. If the parties are unable to
mutually agree upon an arbitrator, then the arbitration proceedings shall be held before three
arbitrators, one of which shall be designated by the Employer, one of which shall be designated by
the claimant and the third of which shall be designated mutually by the first two arbitrators in
accordance with the arbitration rules referenced above. The arbitrator(s) sole authority shall be
to interpret and apply the provisions of this Agreement; the arbitrator(s) shall not change, add
to, or subtract from, any of the Agreement’s provisions. The arbitrator(s)

10

 

shall have the power to compel attendance of witnesses at the hearing. Any court having
jurisdiction may enter a judgment based upon such arbitration. Except as set forth in Section
7.18, the decision of the arbitrator(s) shall be final and binding on the parties to this Agreement
and without appeal to any court. Except as set forth in Section 7.18, upon execution of this
Agreement, the Employee shall be deemed to have waived any right to commence litigation proceedings
regarding this Agreement outside of arbitration without the express written consent of the
Employer.

          (b) In the case of a dispute relating to severance payments provided by Section 6.2, the
decision of the arbitrator(s) shall be delivered or mailed to the claimant within sixty (60) days
of the claimant’s initial request for review of the denied clam under Section 7.18, unless special
circumstances require an extension of time. If an extension is needed the arbitrator(s) shall,
before the end of the sixty (60) day period, give to the claimant written notice of the special
circumstances requiring the extension and the date by which the arbitrator(s) expect(s) to render a
decision. The extension of time shall not exceed sixty (60) days from the end of the initial sixty
(60) day period. Notwithstanding the provisions of Section 7.19(b), in the case of a dispute
relating to severance payments provided by Section 6.2, the claimant shall not be precluded from
challenging the arbitrator’s decision under Section 502(a) of ERISA.

     7.20 ERISA. The severance compensation provided by Section 6.2 of this Agreement constitutes
an unfunded compensation arrangement for a member of a select group of the Employer’s management
and any exemptions under ERISA, as applicable to such an arrangement, shall be applicable to this
Agreement. Section 7.18, Section 7.19(b), Section 7.20 apply to the severance compensation
provided by Section 6.2 of this Agreement.

     7.21 Reporting and Disclosure. The Employer, from time to time, shall provide government
agencies with such reports concerning this Agreement as may be required by law, and the Employer
shall provide the Employee with such disclosure concerning this Agreement as may be required by law
or as the Employer may deem appropriate.

     8. Employee’s Representations. Employee represents and warrants that Employee (i) is free to
enter into this Agreement and to perform each of the terms and covenants contained herein, (ii) is
not restricted or prohibited, contractually or otherwise, from entering into and performing this
Agreement, and (iii) will not be in violation or breach of any other agreement by reason of
Employee’s execution and performance of this Agreement.

11

 

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the date set forth above.

	 	 	 	 	 	 	 
	 	 	EMPLOYER:	 	 
	 
	 	 	 	 	 	 
	 	 	Aastrom Biosciences, Inc.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

R. Douglas Armstrong, Ph.D.
	 	 
	 
	 	 	 	 	 	 
	 	 	EMPLOYEE:	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	James A. Cour	 	 
	 
	 	 	 	 	 	 
	 

	 	Address:	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	 

12

 

EXHIBIT A

TO AASTROM BIOSCIENCES, INC.

EMPLOYMENT AGREEMENT

RELEASE AGREEMENT

     THIS AGREEMENT (“Agreement”) is made by and between James A. Cour (“Executive”) and Aastrom
Biosciences, Inc. (the “Company”).

RECITALS

     A. Executive has terminated employment as an executive officer of Company, effective
                    , ___.

     B. Executive has been given the opportunity to review this Agreement, to consult with legal
counsel, and to ascertain his rights and remedies.

     C. Executive and Company, without any admission of liability, desire to settle with finality,
compromise, dispose of, and release any and all claims and demands asserted or which could be
asserted arising out of Executive’s employment at and separation from Company.

     In consideration of the foregoing and of the promises and mutual covenants contained herein,
it is hereby agreed between Executive and Company as follows:

AGREEMENT

     1. In exchange for the good and valuable consideration set forth in that certain Employment
Agreement, made as of January ___, 2006, between the Company and Executive (the “Employment
Agreement”), Executive hereby releases, waives and discharges any and all manner of action, causes
of action, claims, rights, charges, suits, damages, debts, demands, obligations, attorneys fees,
and any and all other liabilities or claims of whatsoever nature, whether in law or in equity,
known or unknown, including, but not limited to, age discrimination under The Age Discrimination In
Employment Act of 1967 (as amended), employment discrimination prohibited by other federal, state
or local laws, and any other claims, which Executive has claimed or may claim or could claim in any
local, state or federal or other forum, against Company, its directors, officers, employees,
agents, attorneys, successors and assigns as a result of or relating to Executive’s employment at
and separation from Company and as an officer of Company as a result of any acts or omissions by
Company or any of its directors, officers, employees, agents, attorneys, successors or assigns
(“Covered Acts or Omissions”) which occurred prior to the date of this Agreement; excluding only
(i) those to compel the payment of amounts due to Executive as provided in the Employment
Agreement, (ii) enforcement of any rights of Executive under any stock option agreements with the
Company or (iii) those for indemnification under the Company’s articles of incorporation, bylaws or
applicable law by reason of his service as an officer or director of the Company.

     2. Executive agrees to immediately return to Company all property, assets, manuals, materials,
information, notes, reports, agreements, memoranda, customer lists, formulae, data, know-how,
inventions, trade secrets, processes, techniques, and all other assets, materials and

 

 

information of any kind or nature, belonging or pertaining to Company (“Company Information
and Property”), including, but not limited to, computer programs and diskettes or other media for
electronic storage of information containing Company Information and Property, in Executive’s
possession, and Executive shall not retain copies of any such Company Information and Property.
Executive further agrees that from and after the date hereof he will not remove from Company’s
offices any Company Information and Property, nor retain possession or copies of any Company
Information and Property.

     3. Executive agrees that he shall never make any statement that negatively affects the
goodwill or good reputation of the Company, or any officer or director of Company, except as
required by law, and except that such statements may be made to members of the Board of Directors
of the Company.

     4. Executive covenants and agrees that he shall never commence or prosecute, or knowingly
encourage, promote, assist or participate in any way, except as required by law, in the
commencement or prosecution, of any claim, demand, action, cause of action or suit of any nature
whatsoever against Company or any officer, director, employee or agent of Company (“Covered
Litigation”) that is based upon any claim, demand, action, cause of action or suit released
pursuant to this Agreement or involving or based upon the Covered Acts and Omissions.

     5. Executive further agrees that he has read this Agreement carefully and understands all of
its terms.

     6. Executive understands and agrees that he was advised to consult with an attorney and did so
prior to executing this Agreement.

     7. Executive understands and agrees that he has been given twenty-one (21) days within which
to consider this Agreement.

     8. Executive understands and agrees that he may revoke this Agreement for a period of seven
(7) calendar days following the execution of this Agreement (the “Revocation Period”). This
Agreement is not effective until this revocation period has expired. Executive understands that
any revocation, to be effective, must be in writing and either (a) postmarked within seven (7) days
of execution of this Agreement and addressed to Aastrom Biosciences, Inc., 24 Frank Lloyd Drive,
Ann Arbor, Michigan 48105 or (b) hand delivered within seven (7) days of execution of this
Agreement to Aastrom Biosciences, Inc., 24 Frank Lloyd Drive, Ann Arbor, Michigan 48105.
Executive understands that if revocation is made by mail, mailing by certified mail, return receipt
requested, is recommended to show proof of mailing.

     9. In agreeing to sign this Agreement and separate from Company, Executive is doing so
completely voluntarily and of his own free-will and without any encouragement or pressure from
Company and agrees that in doing so he has not relied on any oral statements or explanations made
by Company or its representatives.

     10. Both parties agree not to disclose the terms of this Agreement to any third party, except
as is required by law, or as is necessary for purposes of securing counsel from either parties’
attorneys or accountants.

2

 

     11. This Agreement shall not be construed as an admission of wrongdoing by Company.

     12. This Agreement contains the entire agreement between Executive and Company regarding the
matters set forth herein. Any modification of this Agreement must be made in writing and signed by
Executive and each of the entities constituting the Company.

     13. This Agreement shall be governed by and construed in accordance with the domestic laws of
the State of Michigan, without giving effect to any choice of law or conflict of law provision or
rule (whether of the State of Michigan or any other jurisdiction) that would cause the application
of the laws of any jurisdiction other than the State of Michigan.

     14. In the event any provision of this Agreement or portion thereof is found to be wholly or
partially invalid, illegal or unenforceable in any judicial proceeding, then such provision shall
be deemed to be modified or restricted to the extent and in the manner necessary to render the same
valid and enforceable, or shall be deemed excised from this Agreement, as the case may require, and
this Agreement shall be construed and enforced to the maximum extent permitted by law, as if such
provision had been originally incorporated herein as so modified or restricted, or as if such
provision had not been originally incorporated herein, as the case may be.

     15. If there is a breach or threatened breach of the provisions of this Agreement, Company
may, in addition to other available rights and remedies, apply to any court of competent
jurisdiction for specific performance and/or injunctive relief in order to enforce, or prevent any
violation of, any of the provisions of this Agreement.

     16. In the event that Executive violates the terms of this Agreement, in addition to other
available rights and remedies, the Company shall be released of all of its remaining obligations
under the Severance Agreement.

     The parties hereto have entered into this Agreement as of this                    day of
                    , ___.

	 	 	 	 	 	 	 
	 	 	AASTROM BIOSCIENCES, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

	 	 
	 
	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	 	 	 

	 	 
	 
	 	 	 	 	 	 
	 

	 	Title:	 	 	 	 
	 

	 	 	 	 

	 	 
	 
	 	 	 	 	 	 
	 	 	EXECUTIVE	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	James A. Cour	 	 

3

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