Document:

Exhibit 10.1

June 20, 2006

Mr. Glenn E. Harder

4101 John S. Raboteau

Raleigh, NC 27612

Dear
Glenn:

Set
forth below are the terms and conditions of your engagement as Non-Executive
Chairman of the Board of Directors of DPL Inc. (the “Board”). Your responsibilities
as Non-Executive Chairman of the Board are described in the Responsibilities
Statement attached hereto as Appendix A.

Duration.
You will serve as
Non-Executive Chairman of the Board for such period as determined by the Board
in its sole discretion; provided that you will cease to serve as Non-Executive
Chairman if your service as a member of the Board ends for any reason
(including, without limitation, because you are not nominated for reelection or
are not reelected to the Board).

Compensation.  During your
service on the Board you will be entitled to the same fees and payments as
other directors for the services rendered and the Board positions filled by you
from time to time. For your service as Non-Executive Chairman, you will receive
an additional annual retainer of $125,000 payable in four equal quarterly
installments and prorated for any partial year of service as Non-Executive
Chairman, in addition to any other director fees paid for board service.

Non-Competition.
 In consideration of DPL entering into this
Agreement and as an inducement for it to do so, and in consideration of the
payments set forth above, you agree that during your service as a member of the
Board, you will not, without DPL’s prior written consent, directly or
indirectly, (i) participate or be interested in any business (a) which
is engaged in Ohio, Indiana, Kentucky, Michigan and/or Pennsylvania in
providing (as a public utility or otherwise) electric power or services on a
retail and/or wholesale basis or in providing energy marketing, aggregation
and/or procurement services, or (b) which is engaged in any other business
that would be in direct competition with any business being conducted or
proposed to be conducted by DPL or its subsidiaries (collectively, the “Company”);
(ii) solicit for employment with yourself or any firm or entity with which
you are associated, any employee of the Company or otherwise disrupt, impair,
damage or interfere with the Company’s relationship with its employees; (iii) solicit
for your own behalf or on behalf of any other person(s), any customer of the
Company that has purchased products or services from the Company at any time in
the twelve (12) months preceding the date of such solicitation or that the
Company is actively soliciting or have known plans to solicit, for the purpose
of marketing or distributing any product, pricing or service competitive with
any product, pricing or service then offered by the Company or which the
Company has known plans to offer; or (iv) engage or be affiliated with any
person(s), in the development or marketing, including but not limited to the
establishment of product or service prices, of any product or service which
will compete with any product or service the Company is then developing or
marketing in any geographic market where the Company is doing or preparing to
do business.

 

Confidentiality.
At all times, you (i) will
keep all confidential, nonpublic and/or proprietary information (including, for
example, trade secrets, financial information, customer information and
business and strategic plans) of the Company (regardless of when you became
aware of such information) in strict confidence and (ii) will not,
directly or indirectly, use or disclose to any person in any manner any of such
information, except to the extent directly related to and required by the
performance of your duties on the Board. You will take all appropriate steps to
safeguard such information and to protect it against unauthorized disclosure,
misuse, loss or theft.

Expenses.
You will be reimbursed for all reasonable business expenses incurred in
the course of your service as a member of the Board in accordance with
applicable policy. You shall be entitled to use any company-owned or leased
aircraft for business travel to attend Board meetings and other meetings with
employees, Board members, public officials, etc. that are necessary to carry
out your duties.

Indemnification   The Company shall indemnify you against any
and all losses, liabilities, damages, expenses (including attorneys’ fees)
judgments, fines and amounts paid in settlement incurred by you in connection
with any claim, action, suit or proceeding (whether civil, criminal,
administrative or investigative), including any action by or in the right of
either of the Company, by reason of any act or omission to act in connection
with the performance of your duties on the Board to the full extent that the
Company is permitted to indemnify a director against the foregoing under Ohio
law, including, without limitation, Section 1701.13(E) of the Ohio
Revised Code. The Company shall at all times cause you to be included, as a
Board member, under all liability insurance coverage (or similar insurance
coverage) maintained by the Company from time to time in respect of your
service on the Board. Upon your written request and substantiation, the Company
shall make prompt payment of the legal fees and expenses incurred in connection
with an indemnifiable claim involving you (but not more frequently than once
per calendar quarter); provided that if it is finally determined by a court
that you are not entitled to indemnification under Ohio law with respect to a
claim for which you legal fees and expenses were paid, then any legal fees and
expenses paid by the Company shall be immediately repaid to the Company by you.

If you agree to the foregoing terms, please so
indicate by executing this letter agreement below.

	
  

  	
   

  	
  Sincerely,

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
  /s/ James V. Mahoney

  
	
   

  	
   

  	
  James V. Mahoney

  
	
   

  	
   

  	
  President and Chief Executive Officer

  

 

Agreed and accepted this 20th day of June, 2006 by

	
   

  	
   

  
	
  /s/ Glenn E. Harder

  	
   

  
	
  Glenn E. Harder

  	
   

  

 

 

APPENDIX A

Responsibilities of the Non-Executive Chairman of the Board

POSITION SUMMARY

Presides at all meetings of Board of Directors. Provides leadership to
the Board in reviewing and deciding upon matters which exert major influence on
the manner in which the corporation’s business is conducted. Acts in a general
advisory capacity to the Chief Executive Officer in all matters concerning the
interests and management of the corporation. Performs such duties as may be
conferred by law or assigned by the Board of Directors.

POSITION RESPONSIBILITIES

Prepares agendas for and convenes and conducts regular and special
meetings of the Board of Directors.

Guides the Board’s in the full discharge of its duties.

Advises and gives counsel to the CEO. Reviews strategic direction,
major activities and plans with the CEO to ensure conformity with the Board’s
views on corporate policy.

Possesses the same powers as the CEO to sign all certificates,
contracts, and other instruments of the corporation, which may be authorized by
the Board.

Exercises all powers and discharges all of the duties of the CEO in
that individual’s absence.

Carry out special agreed upon assignments in collaboration with the CEO
or Board of Directors.

Counsels collectively and individually with members of the Board,
utilizing their capacities to the fullest extent necessary to secure optimum
benefits for the corporation.

Presides at all meetings of stockholders. Shall be an ex officio
(non-voting) member of all standing committees.

Identifies guidelines for conduct of the director, leads board’s effort
to identify and recruit directors and assesses each director’s performance
annually.Exhibit 10.1

PONIARD PHARMACEUTICALS, INC.

AMENDED AND RESTATED

2004 INCENTIVE COMPENSATION PLAN

(As amended and restated on June 16, 2006,
including to reflect name change)

SECTION 1. PURPOSE

The purpose of the Poniard
Pharmaceuticals Amended and Restated 2004 Incentive Compensation Plan (this “Plan”)
is to provide a means whereby selected employees, officers, directors, agents,
consultants, advisors and independent contractors of Poniard Pharmaceuticals, Inc.
(formerly NeoRx Corporation) (the “Company”) or of any Related Corporation, may
be granted Incentive Stock Options, Nonqualified Stock Options, Restricted
Stock or Stock Units, in order to attract and retain the services or advice of
such employees, officers, directors, agents, consultants, advisors and
independent contractors and to provide added incentive to such persons by
encouraging stock ownership in the Company.

SECTION 2.
DEFINITIONS

Certain terms used in this Plan have
the meanings set forth in Appendix I.

SECTION 3.
ELIGIBILITY

Incentive Stock Options may be granted
only to an individual who, at the time the Option is granted, is an employee of
the Employer. Nonqualified Stock Options, Restricted Stock or Stock Units may
be granted to any employee, officer, director, agent, consultant, advisor or
independent contractor of the Employer; provided, however, that such agent,
consultant, advisor or independent contractor render bona fide services that
are not in connection with the offer and sale of the Company’s securities in a
capital-raising transaction and do not directly or indirectly promote or
maintain a market for the Company’s securities.

SECTION 4.
AWARDS

4.1          Form,
Grant and Settlement of Awards

The Plan Administrator shall have the
authority, in its sole discretion, to determine the type or types of Awards to
be granted under the Plan. Awards may be granted singly or in combination. Any
Award settlement may be subject to such conditions, restrictions and
contingencies, as the Plan Administrator shall determine.

4.2          Deferrals

The Plan Administrator may permit or
require a Participant to defer receipt of the payment of any Award. If any such
deferral election is permitted or required, the Plan Administrator, in its sole
discretion, shall establish rules and procedures for such payment deferrals,
which may include the grant of additional Awards or provisions for the payment
or crediting of interest or dividend equivalents, including converting such
credits to deferred share unit equivalents. The value of any payment so
deferred shall be allocated to a deferred account established for a Participant
under any deferred compensation plan of the Company designated by the Plan
Administrator. Any deferral made under this Section 4.2 shall satisfy the
requirements for exemption under Section 409A of the Code.

SECTION 5. STOCK SUBJECT TO
THIS PLAN

5.1          Authorized
Number of Shares

Subject to
adjustment from time to time as provided in Section 10.1, a maximum of ten
million (10,000,000) shares of Common Stock shall be available for issuance
under the Plan. Shares of Common Stock issued under the Plan shall be drawn
from authorized and unissued shares or shares now held or subsequently acquired
by the Company.

5.2          Share
Usage

Shares of Common
Stock covered by an Award shall not be counted as used unless and until they
are actually issued and delivered to a Participant. If any Award lapses,
expires, terminates or is canceled prior to the issuance of shares of Common
Stock 

 

hereunder
or if shares of Common Stock are issued under this Plan to a Participant and
thereafter are forfeited to or otherwise reacquired by the Company, the shares
of Common Stock subject to such Awards and the forfeited or reacquired shares
of Common Stock shall again be available for issuance under the Plan. Any
shares of Common Stock not issued because they were (i) tendered by a
Participant or retained by the Company as full or partial payment to the
Company for the exercise of an Option, purchase price of an Award or to satisfy
tax withholding obligations in connection with an Award or (ii) covered by
an Award that is settled in cash or in a manner such that some or all of the
shares of Common Stock covered by the Award are not issued to a Participant
shall be available for Awards under the Plan. The number of shares of Common
Stock available for issuance under the Plan shall not be reduced to reflect any
dividends or dividend equivalents that are reinvested into additional shares or
credited as additional Restricted Stock or Stock Units. Notwithstanding the
foregoing, any such shares of Common Stock shall be counted in accordance with
the requirements of Section 162(m) of the Code.

Notwithstanding
anything in the Plan to the contrary, the Plan Administrator may grant
Substitute Awards under the Plan. Substitute Awards shall not reduce the number
of shares of Common Stock authorized for issuance under the Plan. In the event
that an Acquired Entity has shares available for awards or grants under one or
more preexisting plans not adopted in contemplation of such acquisition or
combination, then, to the extent determined by the Board or the Plan
Administrator, the shares available for grant pursuant to the terms of such
preexisting plan (as adjusted, to the extent appropriate, using the exchange
ratio or other adjustment or valuation ratio or formula used in such
acquisition or combination to determine the consideration payable to holders of
common stock of the entities that are parties to such acquisition or
combination) may be used for Awards under the Plan and shall not reduce the
number of shares of Common Stock authorized for issuance under the Plan;
provided, however, that Awards using such available shares of Common Stock
shall not be made after the date awards or grants could have been made under
the terms of such preexisting plans, absent the acquisition or combination, and
shall only be made to individuals who were not employees or non-employee
directors of the Employer prior to such acquisition or combination. In the
event that a written agreement between the Company and an Acquired Entity
pursuant to which a merger or consolidation is contemplated is approved by the
Board and said agreement sets forth the terms and conditions of the
substitution for or assumption of outstanding awards of the Acquired Entity,
said terms and conditions shall be deemed to be the action of the Plan
Administrator without any further action by the Plan Administrator, except as
may be required for compliance with Rule 16b-3 under the Exchange
Act, and the persons holding such awards shall be deemed to be Participants.

The maximum number
of Common Stock that may be issued upon exercise of Incentive Stock Options
shall equal the aggregate share number stated in Section 5.1, subject to
adjustment as provided in Section 10.1.

SECTION 6. PLAN TERMS AND
CONDITIONS OF OPTIONS

The Plan Administrator may grant
Options designated as Incentive Stock Options or Nonqualified Stock Options.
Options granted under this Plan shall be evidenced by written (including
electronic) agreements which shall contain such terms, conditions, limitations
and restrictions as the Plan Administrator shall deem advisable and which are
not inconsistent with this Plan. Notwithstanding the foregoing, Options shall
include or incorporate by reference the following terms and conditions:

6.1          Option
Exercise Price

The Exercise Price for a share of
Common Stock under an Option shall not be less than 100% of the fair market
value of a share of Common Stock for the grant date, except in the case of
Substitute Awards. With respect to Incentive Stock Options granted to a Ten
Percent Shareholder, the Exercise Price shall be as required by Section 7.3.

6.2          Term
and Vesting

Subject to the restrictions contained
in Section 7 with respect to granting Incentive Stock Options to Ten
Percent Shareholders, the term of each Option shall be as established by the
Plan Administrator and, if not so established, shall be 10 years. To ensure
that the Employer will achieve the purpose and receive the benefits
contemplated in this Plan, any Option granted to any Participant hereunder
shall, unless the condition of this sentence is waived or modified in the
agreement evidencing the Option or by resolution adopted at any time by the
Plan Administrator, be exercisable as follows:

•       Option
grants for existing employees with at least one year of service and existing
employees receiving promotions become exercisable in monthly increments over a
four-year period from the grant date.

•       Option
grants for new employees with less than one year of service become exercisable
at a rate of 25% one year after the date of grant and thereafter in equal
monthly amounts over the next three years.

 

Unless the Plan Administrator (or the
Company’s Chief Executive Officer in the case of Participants who are not
subject to Section 16 under the Exchange Act) determines otherwise, the
vesting schedule of an Option shall be adjusted proportionately to the
extent a Participant’s hours of employment or service are reduced after the
date of grant.

6.3          Exercise

Subject to the vesting
schedule described in Section 6.2, each Option may be exercised in
whole or in part at any time and from time to time; provided, however, that an
Option may not be exercised for less than a reasonable number of shares at any
one time, as determined by the Plan Administrator. Only whole shares will be
issued pursuant to the exercise of any Option. To the extent an Option has
vested and become exercisable, the Option may be exercised by delivery to the
Company of a properly executed stock Option exercise agreement or notice, in a
form and in accordance with procedures established by the Plan Administrator,
setting forth the number of shares of Common Stock with respect to which the
Option is being exercised, the restrictions imposed on the shares of Common
Stock purchased under such exercise agreement, if any, and such representations
and agreements as may be required by the Plan Administrator, together with
payment of the exercise price.

6.4          Payment
of Exercise Price

Payment of the Option exercise price
shall be made in full at the time the notice of exercise of the Option is
delivered to the Company and shall be in cash, bank certified or cashier’s
check or personal check (unless at the time of exercise the Plan Administrator
in a particular case determines not to accept a personal check) for the Common
Stock being purchased.

The Plan Administrator can determine
at any time before exercise that additional forms of payment will be permitted.
Unless the Plan Administrator in its sole discretion determines otherwise,
either at the time the Option is granted or at any time before it is exercised,
and to the extent permitted by applicable laws and regulations (including, but
not limited to, federal tax and securities laws and regulations and state
corporate law), an Option may be exercised by a combination of cash and/or
check and one or more of the following alternative forms:

(a)            tendering (either actually or by attestation) shares of
Common Stock already owned by the Participant for at least six months (or any
other period necessary to avoid adverse accounting consequences)  having a fair market value equal to the
aggregate exercise price of the shares of Common Stock being purchased under
the Option;

(b)           delivery of a properly executed exercise notice, together
with irrevocable instructions to a broker, all in accordance with the
regulations of the Federal Reserve Board, to promptly deliver to the Company
the amount of proceeds to pay the Option exercise price and withholding tax
obligations that may arise in connection with the exercise; or

(c)            such other consideration as the Plan Administrator may
permit.

6.5          Termination
of Relationship

The Plan Administrator shall establish
and set forth in each instrument that evidences an Option whether the Option
shall continue to be exercisable, and the terms and conditions of such
exercise, after a Termination of Service, any of which provisions may be waived
or modified by the Plan Administrator at any time. If not so established in the
instrument evidencing the Option, the Option shall be exercisable according to
the following terms and conditions, which may be waived or modified by the Plan
Administrator at any time:

(a)           Any
portion of an Option that is not vested and exercisable on the date of a
Participant’s Termination of Service shall expire on such date.

(b)           Any
portion of an Option that is vested and exercisable on the date of a
Participant’s Termination of Service shall expire on the earliest to occur:

(i)            if the Participant’s Termination of
Service occurs for reasons other than Cause, Retirement, Total Disability or
death, the date that is three months after the date of such Termination of
Service;

(ii)           if the Participant’s Termination of
Service occurs by reason of Total Disability or death, the date that is one
year after the date of such Termination of Service;

(iii)          if the Participant’s Termination of
Service occurs by reason of Retirement, the date that is two years after

 

the
date of such Termination of Service; and

(iv)          the Option Expiration Date.

Notwithstanding the foregoing, if a
Participant dies after his or her Termination of Service but while an Option is
otherwise exercisable, the portion of the Option that is vested and exercisable
on the date of such Termination of Service shall expire upon the earlier to
occur of the Option Expiration Date and the one-year anniversary of the date of
death, unless the Plan Administrator determines otherwise.

Also notwithstanding the foregoing, in
case a Participant’s Termination of Service occurs for Cause, all Options
granted to the Participant shall automatically expire as of the first discovery
by the Company of any reason for termination for Cause, unless the Plan
Administrator determines otherwise. If a Participant’s employment or service
relationship with the Company is suspended pending an investigation of whether
the Participant shall be terminated for Cause, all the Participant’s rights
under any Option shall likewise be suspended during the period of investigation.
If any facts that would constitute termination for Cause are discovered after a
Participant’s Termination of Service, any Option then held by the Participant
may be immediately terminated by the Plan Administrator, in its sole
discretion.

If, however, in the case of an
Incentive Stock Option, the Participant does not exercise the Participant’s
Option within the periods set forth in Section 7.5, the Option will no
longer qualify as an Incentive Stock Option under the Code.

Any change of relationship with the
Company shall not constitute a termination of the Participant’s relationship
with the Employer for purposes of this Section 6.5
so long as the Participant continues to be an employee, officer, director or,
pursuant to a written agreement with the Employer (unless the Plan
Administrator or the Company’s Chief Executive Officer in the case of
Participants who are not subject to Section 16 under the Exchange Act
determines a written agreement is not necessary with respect to such
individual), an agent, consultant, advisor or independent contractor of the
Employer. The Plan Administrator, in its absolute discretion, may determine all
questions of whether particular leaves of absence constitute a Termination of Services;
provided, however, that with respect to Incentive Stock Options, such
determination shall be subject to any requirements contained in the Code. The
foregoing notwithstanding, with respect to Incentive Stock Options, employment
shall not be deemed to continue beyond the first 90 days of such leave, unless
the Participant’s reemployment rights are guaranteed by statute or by contract.

SECTION 7. INCENTIVE STOCK
OPTION LIMITATIONS

Notwithstanding any other provisions
of the Plan, to the extent required by Section 422 of the Code, Incentive
Stock Options shall be subject to the following additional terms and
conditions:

7.1          Dollar
Limitation

To the extent the aggregate fair
market value (determined as of the grant date) of Common Stock with respect to
which a Participant’s Incentive Stock Options become exercisable for the first
time during any calendar year (under the Plan and all other stock option plans
of the Company and its parent and subsidiary corporations) exceeds $100,000,
such portion in excess of $100,000 shall be treated as a Nonqualified Stock
Option. In the event the Participant holds two or more such Options that become
exercisable for the first time in the same calendar year, such limitation shall
be applied on the basis of the order in which such Options are granted.

7.2          Eligible
Employees

Individuals who are not employees of
the Company or a Related Corporation may not be granted Incentive Stock
Options.

7.3          Exercise
Price

The exercise price of an Incentive
Stock Option shall be at least 100% of the fair market value of the Common
Stock on the grant date, and in the case of an Incentive Stock Option granted
to a Ten Percent Stockholder, shall not be less than 110% of the fair market
value of the Common Stock on the grant date.

7.4          Option
Term

Subject to earlier termination in
accordance with the terms of the Plan and the instrument evidencing the Option,
the maximum term of an Incentive Stock Option shall not exceed ten years, and
in the case of an Incentive Stock Option granted to a Ten 

 

Percent Stockholder, shall not exceed
five years.

7.5          Exercisability

An Option designated as an Incentive Stock Option
shall cease to qualify for favorable tax treatment as an Incentive Stock Option
to the extent it is exercised (if permitted by the terms of the Option) (a) more
than three months after the date of a Participant’s Termination of Service if
termination was for reasons other than death or Disability, (b) more than
one year after the date of a Participant’s Termination of Service if
termination was by reason of Disability, or (c) after the Participant has
been on leave of absence for more than 90 days, unless the Participant’s
reemployment rights are guaranteed by statute or contract.

7.6          Holding
Periods and Taxation of Incentive Stock Options

In order to obtain certain tax benefits afforded to
Incentive Stock Options under Section 422 of the Code, the Participant
must hold the shares acquired upon the exercise of an Incentive Stock Option
for two years after the date of grant of the Option and one year after the date
of exercise. The Participant shall give the Company prompt notice of any
disposition of shares acquired on the exercise of an Incentive Stock Option
prior to the expiration of such holding periods.

7.7          Compliance
With Laws and Regulations

In interpreting and applying the
provisions of the Plan, any Option granted as an Incentive Stock Option
pursuant to the Plan shall, to the extent permitted by law, be construed as an “incentive
stock option” within the meaning of Section 422 of the Code.

SECTION 8. RESTRICTED STOCK
AND STOCK UNITS

8.1          Grant
of Restricted Stock and Stock Units

The Plan Administrator may grant Restricted Stock and
Stock Units on such terms and conditions and subject to such repurchase or
forfeiture restrictions, if any (which may be based on continuous service with
the Employer or the achievement of any performance criteria, as the Plan
Administrator shall determine in its sole discretion), which terms, conditions
and restrictions shall be set forth in the instrument evidencing the Award.

8.2          Issuance
of Shares; Settlement of Awards

Upon the satisfaction of any terms, conditions and
restrictions prescribed with respect to Restricted Stock or Stock Units, or
upon a Participant’s release from any terms, conditions and restrictions of
Restricted Stock or Stock Units, as determined by the Plan Administrator, (a) the
shares of Restricted Stock covered by each Award of Restricted Stock shall
become freely transferable by the Participant, and (b) Stock Units shall
be paid in shares of Common Stock or, if set forth in the instrument evidencing
the Awards, in a combination of cash and shares of Common Stock as the Plan
Administrator shall determine in its sole discretion. Any fractional shares
subject to such Awards shall be paid to the Participant in cash.

8.3          Dividends
and Distributions

Participants holding shares of Restricted Stock or
Stock Units may, if the Plan Administrator so determines, be credited with
dividends paid with respect to the underlying shares or dividend equivalents
while they are so held in a manner determined by the Plan Administrator in its
sole discretion. The Plan Administrator may apply any restrictions to the
dividends or dividend equivalents that the Plan Administrator deems appropriate.
The Plan Administrator, in its sole discretion, may determine the form of
payment of dividends or dividend equivalents, including cash, shares of Common
Stock, Restricted Stock or Stock Units.

8.4          Waiver
of Restrictions

Notwithstanding any other provisions
of the Plan, the Plan Administrator, in its sole discretion, may waive the
repurchase or forfeiture period and any other terms, conditions or restrictions
on any Restricted Stock or Stock Unit under such circumstances and subject to
such terms and conditions as the Plan Administrator shall deem appropriate.

SECTION 9. ADMINISTRATION

This Plan shall be administered by the
Board or a committee or committees (which term includes subcommittees)
appointed by, and consisting of two or more members of, the Board. If and so
long as the Common Stock is registered under Section 12(b) or 

 

12(g) of the Exchange Act, the
Board shall consider, in selecting the Plan Administrator and the membership of
any committee acting as Plan Administrator of this Plan with respect to any
persons subject or likely to become subject to Section 16 under the
Exchange Act, the provisions regarding (a) “outside directors,” as contemplated
by Section 162(m) of the Code, and (b) “nonemployee directors,”
as contemplated by Rule 16b-3 under the Exchange Act. The Board may
delegate the responsibility for administering this Plan with respect to
designated classes of eligible participants to different committees, subject to
such limitations as the Board deems appropriate. Committee members shall serve
for such term as the Board may determine, subject to removal by the Board at
any time. To the extent consistent with applicable law, the Board may authorize
one or more senior executive officers of the Company to grant Awards, within
limits specifically prescribed by the Board.

9.1          Procedures

The Board shall designate one of the
members of the Plan Administrator as chairman. The Plan Administrator may hold
meetings at such times and places as it shall determine. The acts of a majority
of the members of the Plan Administrator present at meetings at which a quorum
exists, or acts reduced to or approved in writing by all Plan Administrator
members, shall be valid acts of the Plan Administrator.

9.2          Responsibilities

Except for the terms and conditions
explicitly set forth in this Plan, the Plan Administrator shall have the
authority, in its discretion, to determine all matters relating to the Awards
under this Plan, including selection of the individuals to be granted Awards,
the determination of the type of Award, the number of shares of Common Stock
subject to an Award, and all terms, conditions, restrictions and limitations,
if any, of the Awards. Grants under this Plan need not be identical in any
respect, even when made simultaneously. The interpretation and construction by
the Plan Administrator of any terms or provisions of this Plan or any Award
issued hereunder, or of any rule or regulation promulgated in connection
herewith, shall be conclusive and binding on all interested parties, so long as
such interpretation and construction with respect to Incentive Stock Options
correspond to the requirements of Section 422 of the Code, the regulations
thereunder and any amendments thereto.

SECTION 10.
ADJUSTMENTS UPON CHANGES IN CAPITALIZATION

10.1        Adjustment
of Shares

The aggregate number and class of
shares for which Awards may be granted under this Plan, the maximum annual
Award grant set forth in Section 13.3, the number and class of shares of
Common Stock covered by each outstanding Award and the price per share of each
outstanding Award (but not the total price), and  the number and class of shares for which
Awards may be automatically granted pursuant to a formula program established
under the Plan shall all be proportionately adjusted for any increase or
decrease in the number of issued shares of Common Stock of the Company
resulting from a split-up or consolidation of shares or any like capital adjustment,
or the payment of any stock dividend. The determination by the Plan
Administrator as to the terms of any of the foregoing adjustments shall be
conclusive and binding.

10.2        Effect
of Certain Corporate Transactions

Upon a Corporate Transaction, the exercisability
of each Option outstanding under this Plan shall be automatically accelerated
so that each such Option shall, immediately prior to the specified effective
date for the Corporate Transaction, become fully exercisable with respect to
the total number of shares of Common Stock purchasable under such Option and
may be exercised for all or any portion of such shares. To the extent such
Option is not exercised, it shall terminate, except that in the event of a Corporate
Transaction in which shareholders of the Company receive capital stock of
another corporation in exchange for their shares of Common Stock such
unexercised Option shall be assumed or an equivalent Option shall be
substituted by such successor corporation or a parent or subsidiary of such
successor corporation. Any such assumed or equivalent Option shall be fully
exercisable with respect to the total number of shares purchasable under such
Option.

Notwithstanding the foregoing, upon a
merger of the Company in which the holders of Common Stock immediately prior to
the merger have the same proportionate ownership of common stock in the
surviving corporation immediately after the merger, a mere re-incorporation or
the creation of a holding company, each Option outstanding under this Plan shall
be assumed or an equivalent Option shall be substituted by the successor
corporation or a parent or subsidiary of such corporation, and the vesting
schedule set forth in the instrument evidencing the Option shall continue
to apply to such assumed or equivalent Option.

The Plan Administrator shall have the
discretion, exercisable at any time before a sale, merger, consolidation,
reorganization, liquidation, dissolution or change of control of the Company,
as defined by the Plan Administrator, to take such further action as it 

 

determines to be necessary or
advisable with respect to Awards. Such authorized actions may include (but
shall not be limited to) establishing, amending or waiving the type, terms,
conditions or duration of, or restrictions on, Awards so as to provide for
earlier, later, extended or additional time for exercise, lifting restrictions
and other modifications, and the Plan Administrator may take such actions with
respect to all Participants, to certain categories of Participants or only to
individual Participants. The Plan Administrator may take such action before or
after granting Awards to which the action relates and before or after any
public announcement with respect to such sale, merger, consolidation,
reorganization, liquidation, dissolution or change of control that is the
reason for such action.

Without limitation on the foregoing,
the Plan Administrator may, but shall not be obligated to, make a provision in
connection with a Corporate Transaction for a cash payment to each holder of
Awards in consideration for the cancellation of such Awards which may equal the
excess, if any, of the value of the consideration to be paid in the transaction
to holders of the same number of shares of Common Stock subject to such Awards
(or if no consideration is paid in any such transaction, the fair market value
of shares of Common Stock subject to such Awards) over the aggregate purchase
or exercise price, if any, of such Awards.

10.3        Fractional
Shares

In the event of any adjustment in the
number of shares covered by any Award, any fractional shares resulting from
such adjustment shall be disregarded and each such Award shall cover only the
number of full shares resulting from such adjustment.

10.4        Determination
of Board to Be Final

All adjustments under this Section 10
shall be made by the Board, and its determination as to what adjustments shall
be made, and the extent thereof, shall be final, binding and conclusive. Unless
a Participant agrees otherwise, any change or adjustment to an Incentive Stock
Option shall be made in such a manner so as not to constitute a “modification”
as defined in Code Section 424(h) and so as not to cause his or her
Incentive Stock Option issued hereunder to fail to continue to qualify as an
Incentive Stock Option as defined in Code Section 422(b).

10.5        Limitations

The grant of Awards shall in no way
affect the Company’s rights to adjust, reclassify, reorganize or otherwise
change its capital or business structure or to merge, consolidate, dissolve,
liquidate or sell or transfer all or any part of its business or assets.

SECTION 11.
WITHHOLDING

The Employer may require the
Participant to pay to the Employer the amount of (a) any taxes that the
Employer is required by applicable federal, state, local or foreign law to withhold
with respect to the grant, vesting or exercise of an Award (“tax withholding
obligations”) and (b) any amounts due from the Participant to the Employer
(“other obligations”). The Company shall not be required to issue any shares of
Common Stock or otherwise settle an Award under the Plan until such tax
withholding obligations are satisfied. The Employer shall have the right to
withhold from any shares of Common Stock issuable pursuant to an Award or from
any cash amounts otherwise due or to become due from the Employer to the
Participant an amount equal to such taxes.

The Plan Administrator may permit or
require a Participant to satisfy all or part of the Participant’s tax
withholding obligations and other obligations by (a) paying cash to the
Empoyer, (b) having the Employer withhold an amount from any cash amounts
otherwise due or to become due from the Employer to the Participant, (c) having
the Employer withhold a number of shares of Common Stock that would otherwise
be issued to the Participant (or become vested in the case of Restricted Stock)
having a fair market value equal to tax withholding obligations, or (d) surrendering
a number of shares of Common Stock the Participant already owns having a value
equal to the tax withholding obligations. The value of the shares of Common
Stock so withheld may not exceed the employer’s minimum required tax
withholding obligation, and the value of the shares of Common Stock so tendered
may not exceed such obligation to the extent the Participant has owned the
tendered shares for less than six months if such limitation is necessary to
avoid adverse accounting treatment to the Company.

SECTION 12. ASSIGNABILITY

No Award or interest in an Award may
be sold, assigned, pledged (as collateral for a loan or as security for the
performance of an obligation or for any other purpose) or transferred by a
Participant or made subject to attachment or similar proceedings otherwise than
by will or by the applicable laws of descent and distribution, except to the
extent the Participant designates one or more beneficiaries on a
Company-approved form who may exercise the Award or receive payment under the
Award after the Participant’s death. During the Participant’s lifetime, an
Award may be exercised only by the Participant. Notwithstanding the foregoing,
the Plan 

 

Administrator,
in its sole discretion, may permit a Participant to assign or transfer an
Award, subject to the restrictions of Section 422 of the Code with respect
to Incentive Stock Options intended to remain Incentive Stock Options;
provided, however, that any Award so assigned or transferred shall be subject
to all the terms and conditions of the Plan and the instrument evidencing the
Award.

SECTION 13.
CODE SECTION 162(M) PROVISIONS

Notwithstanding any other
provision of the Plan, if the Plan Administrator determines at the time an
Award is granted to a Participant who is, or is likely to be as of the end of
the tax year in which the Company would claim a tax deduction in connection
with such Award, a Covered Employee, then the Plan Administrator may provide
that this Section 13 is applicable to such Award; provided, however, that
an Option granted within the limitations set forth in subsection 13.3 shall be
deemed to have been granted pursuant to this Section 13.

13.1        Performance Criteria

If an Award other than an
Option is subject to this Section 13, then the lapsing of restrictions
thereon and the distribution of shares of Common Stock or other property
pursuant thereto, as applicable, shall be subject to the achievement of one or
more objective performance goals established by the Plan Administrator, which
shall be based on the attainment of specified levels of one of or any
combination of the following “performance criteria” for the Company as a whole
or any business unit of the Company, as reported or calculated by the Company: net income; earnings per share; operating income (including
or excluding depreciation, amortization, extraordinary items, restructuring
charges or other expenses); revenues; operating or gross margins; market or
economic value added; stock price appreciation; total shareholder return; cost
control; cash flows (including, but not limited to, operating cash flow, free
cash flow or return on capital); return on equity; completion of financing or
business development transactions; strategic or operational initiatives;
product sales or market share; product development milestones; research
pipeline advancement; improvements in capital structure; or customer
satisfaction, employee satisfaction or services performance metrics (together,
the “Performance Criteria”). Such performance goals also may be based on the
achievement of specified levels of Company performance (or performance of an
applicable affiliate or business unit of the Company) under one or more of the
Performance Criteria described above relative to the performance of other
corporations. Such performance goals shall be set by the Plan Administrator
within the time period prescribed by, and shall otherwise comply with the
requirements of, Section 162(m) of the Code, or any successor
provision thereto, and the regulations thereunder.

13.2        Plan Administrator Certification and Authority

The Plan
Administrator shall certify the extent to which any Performance Criteria have
been satisfied and the amount payable as a result thereof, prior to payment,
settlement or vesting of any Award subject to this Section 13. Notwithstanding
any provision of the Plan other than Section 10, with respect to any Award
that is subject to this Section 13, the Plan Administrator may adjust
downwards, but not upwards, the amount payable pursuant to such Award.

The Plan
Administrator shall have the power to impose such other restrictions on Awards
subject to this Section 13 as it may deem necessary or appropriate to ensure
that such Awards satisfy all requirements for “performance-based compensation”
within the meaning of Section 162(m)(4)(C) of the Code, or any
successor provision thereto.

13.3        Limitations

Subject to adjustment
from time to time as provided in Section 10, no Participant shall receive
in any one calendar year grants of Awards covering an aggregate of more than 2,000,000
shares of Common Stock, except that in a calendar year when a Participant is
first employed by or provides services for the Employer, such Participant may
receive a one-time grant of Awards for up to 3,000,000 shares of Common
Stock.

SECTION 14.
LEGAL REQUIREMENTS AND SECURITIES REGULATION

The granting of Awards and the
issuance of shares of Common Stock under the Plan is subject to all applicable
laws, rules and regulations, and to such approvals by any governmental
agencies or national securities exchanges as may be required. Shares shall not
be issued with respect to an Award granted under this Plan unless the grant and
exercise of such Award and the issuance and delivery of such shares pursuant
thereto shall comply with all relevant provisions of law, including, without limitation,
any applicable state securities laws, the Securities Act, the Exchange Act, the
rules and regulations promulgated thereunder, and the requirements of any
stock exchange upon which the shares may then be listed, and shall be further
subject to the approval of counsel for the Company with respect to such
compliance, including the availability, if applicable, of an exemption from
registration for the 

 

issuance and sale of any shares
hereunder.

SECTION 15. AMENDMENT AND
TERMINATION

15.1        Board
Action

The Board may at any time suspend,
amend or terminate this Plan or any portion of this Plan, provided that, to the
extent required for compliance with Section 422 of the Code or by any
applicable law, regulation, or stock exchange rule, the Company’s shareholders
must approve any amendment of this Plan. Such shareholder approval must be
obtained within 12 months of the adoption by the Board of such amendment.

Any amendment made to this Plan since
its original adoption which would constitute a “modification” to Incentive
Stock Options outstanding on the date of such amendment shall not be applicable
to such outstanding Incentive Stock Options, but shall have prospective effect
only, unless the Participant agrees otherwise.

15.2        Automatic
Termination

Unless sooner terminated by the Board,
this Plan shall terminate on June 16, 2016. No Award may be granted after
such termination or during any suspension of this Plan. The amendment or
termination of this Plan shall not, without the consent of the Participant,
impair or diminish any rights or obligations under any Award theretofore
granted under this Plan.

15.3        Modification
and Amendment of Award

Subject to the requirements of Code Section 422
with respect to Incentive Stock Options and to the terms and conditions and
within the limitations of this Plan, the Plan Administrator may modify or amend
outstanding Awards granted under this Plan. The modification or amendment of an
outstanding Award shall not, without the consent of the Participant, materially
adversely affect any of his or her rights or any of the obligations of the
Company under such Award. Except as otherwise provided in this Plan, no
outstanding Award shall be terminated without the consent of the Participant.

SECTION 16.
GENERAL

16.1        Participants
in Foreign Countries

The Plan Administrator shall have the
authority to adopt such modifications, procedures and subplans as may be
necessary or desirable to comply with provisions of the laws of other countries
in which the Employer may operate to assure the viability of the benefits from
Awards granted to Participants employed in such countries, to meet the
requirements of local laws that permit the Plan to operate in a qualified or
tax-efficient manner, to comply with applicable foreign law and to meet the
objectives of the Plan.

16.2        No
Individual Rights

No individual or Participant shall
have any claim to be granted any Award under the Plan, and the Company has no
obligation for uniformity of treatment of Participants under the Plan. Furthermore,
nothing in the Plan or any Award granted under the Plan shall be deemed to
constitute an employment contract or confer or be deemed to confer on any
Participant any right to continue in the employ of, or to continue any other
relationship with, the Employer or limit in any way the right of the Employer
to terminate a Participant’s employment or other relationship at any time, with
or without cause.

16.3        No
Rights as a Stockholder

Unless otherwise provided by the Plan
Administrator or in the instrument evidencing the Award or in a written
employment, services or other agreement, no Award shall entitle the Participant
to any cash dividend, voting or other right of a stockholder unless and until
the date of issuance under the Plan of the shares of Common Stock that are the
subject of such Award.

16.4        Issuance
of Shares

Notwithstanding any other provision of
this Plan, the Company shall have no obligation to issue or deliver any shares
of Common Stock under this Plan or make any other distribution of benefits
under this Plan unless, in the opinion of the Company’s counsel, such issuance,
delivery or distribution would comply with all applicable laws (including,
without limitation, the requirements of the Securities Act or the laws of any
state or foreign jurisdiction) and the applicable requirements of any
securities exchange or similar entity.

 

The Company shall be under no
obligation to any Participant to register for offering or resale or to qualify
for exemption under the Securities Act or to register or qualify under the laws
of any state or foreign jurisdiction, any shares of Common Stock, security or
interest in a security paid or issued under, or created by, this Plan, or to
continue in effect any such registrations or qualifications if made.

As a condition to the exercise of an
Option or any other receipt of Common Stock pursuant to an Award under the
Plan, the Company may require (a) the Participant to represent and warrant
at the time of any such exercise or receipt that such shares are being
purchased or received only for the Participant’s own account and without any
present intention to sell or distribute such shares and (b) such other
action or agreement by the Participant as may from time to time be necessary to
comply with the federal, state and foreign securities laws. At the option of
the Company, a stop-transfer order against any such shares may be placed on the
official stock books and records of the Company, and a legend indicating that
such shares may not be pledged, sold or otherwise transferred, unless an
opinion of counsel is provided (concurred in by counsel for the Company)
stating that such transfer is not in violation of any applicable law or
regulation, may be stamped on stock certificates to ensure exemption from
registration. The Plan Administrator may also require the Participant to
execute and deliver to the Company a purchase agreement or such other agreement
as may be in use by the Company at such time that describes certain terms and
conditions applicable to the shares.

To the extent this Plan or any
instrument evidencing an Award provides for issuance of stock certificates to
reflect the issuance of shares of Common Stock, the issuance may be effected on
a noncertificated basis, to the extent not prohibited by applicable law or the
applicable rules of any stock exchange.

16.5        Indemnification

Each person who is or shall have been
a member of the Board, the Plan Administrator, a committee appointed by the
Board or Plan Administrator, or an officer of the Company to whom authority was
delegated in accordance with Section 9 shall be indemnified and held
harmless by the Company against and from any loss, cost, liability or expense
that may be imposed upon or reasonably incurred by such person in connection
with or resulting from any claim, action, suit or proceeding to which such
person may be a party or in which such person may be involved by reason of any
action taken or failure to act under this Plan and against and from any and all
amounts paid by such person in settlement thereof, with the Company’s approval,
or paid by such person in satisfaction of any judgment in any such claim,
action, suit or proceeding against such person; provided, however, that such
person shall give the Company an opportunity, at its own expense, to handle and
defend the same before such person undertakes to handle and defend it on such
person’s own behalf, unless such loss, cost, liability or expense is a result
of such person’s own willful misconduct or except as expressly provided by
statute.

The foregoing right of indemnification
shall not be exclusive of any other rights of indemnification to which such
person may be entitled under the Company’s certificate of incorporation or
bylaws, as a matter of law, or otherwise, or of any power that the Company may
have to indemnify or hold harmless.

16.6        No
Trust or Fund

The Plan is intended to constitute an “unfunded”
plan. Nothing contained herein shall require the Company to segregate any
monies or other property, or shares of Common Stock, or to create any trusts,
or to make any special deposits for any immediate or deferred amounts payable
to any Participant, and no Participant shall have any rights that are greater
than those of a general unsecured creditor of the Company.

16.7        Severability

If any provision of the Plan or any
Award is determined to be invalid, illegal or unenforceable in any
jurisdiction, or as to any person, or would disqualify the Plan or any Award
under any law deemed applicable by the Plan Administrator, such provision shall
be construed or deemed amended to conform to applicable laws, or, if it cannot
be so construed or deemed amended without, in the Plan Administrator’s
determination, materially altering the intent of the Plan or the Award, such
provision shall be stricken as to such jurisdiction, person or Award, and the
remainder of the Plan and any such Option shall remain in full force and
effect.

16.8        Section 409A of the Code

Notwithstanding anything contained in this Plan to the
contrary, any and all Awards, payments, distributions, deferral elections,
transactions and any other actions or arrangements made or entered into
pursuant to this Plan shall remain subject at all times to compliance with the
requirements of Section 409A of the Code.

 

To the extent that the Plan Administrator determines
that any Award granted under this Plan is subject to Section 409A, the
agreement evidencing such Award shall incorporate the terms and conditions
required by Section 409A. Notwithstanding any provision of this Plan to
the contrary, in the event that the Plan Administrator determines that any
Award may be subject to Section 409A, the Plan Administrator may adopt
such amendments to this Plan and the applicable agreement evidencing the Award
or adopt other policies and procedures (including amendments, policies and
procedures with retroactive effect), or take any other actions, that the Plan
Administrator determines are necessary or appropriate to (a) exempt the
Award from Section 409A or (b) comply with the requirements of Section 409A.

16.9        Choice
of Law

The Plan and all determinations made
and actions taken pursuant hereto, to the extent not otherwise governed by the
laws of the United States, shall be governed by the laws of the State of
Washington without giving effect to principles of conflicts of laws.

SECTION 17.
EFFECTIVENESS OF THIS PLAN

This Plan, as amended and restated,
shall become effective upon approval by the Company’s shareholders.

 

APPENDIX I

“Acquired
Entity” means any
entity acquired by the Company or a Related Corporation or with which the
Company or a Related Corporation merges or combines.

“Award” means an Option, Restricted Stock or
Stock Unit.

“Board” means the Board of Directors of the
Company.

“Cause” shall mean fraud, conduct prohibited by
law (except minor violations), misconduct, dishonesty or unauthorized use or
disclosure of confidential information, in each case as determined by the Plan
Administrator. The Plan Administrator’s determination shall be conclusive and
binding.

“Code” means the Internal Revenue Code of 1986,
as it may be amended from time to time.

“Common
Stock” means the
Company’s class of capital stock designed as common stock, or, in the event
that the outstanding shares of Common Stock are after the date this Plan is
approved by the shareholders of the Company, recapitalized, converted into or
exchanged for different stock or securities of the Company, such other stock or
securities.

“Corporate Transaction” means a merger, consolidation,
acquisition of property or stock, separation, reorganization or liquidation of
the Company, as a result of which the shareholders of the Company receive cash,
stock or other property in exchange for or in connection with their shares of
Common Stock. Solely with respect to an Award that is subject to Section 409A,
this definition is intended to comply with the definition of “change in control”
under Section 409A, and, to the extent that the above definition does not
so comply, the definition of “change in control” set forth in Section 409A
shall be incorporated by reference into this Plan as fully as if set forth
herein verbatim and this Plan shall be operated in accordance with the above
definition of Corporate Transaction as modified to the extent necessary to
ensure that the definition complies with Section 409A.

“Disability” means disability as defined in Section 22(e)(3) of
the Code or any successor provision thereto. Notwithstanding the foregoing, “Disability,”
for purposes of Awards subject to Section 409A, has the meaning given such
term under Section 409A.

“Employer” means individually or collectively the
Company or Related Corporations.

“Exchange
Act” means the
Securities Exchange Act of 1934, as amended.

“Exercise
Price” means the
price per share at which an Option is exercisable.

“Incentive
Stock Option”
means an Option granted with the intention that it qualifies as an “incentive
stock option” as that term is defined in Section 422 of the Code or any
successor provision thereto.

“Nonqualified
Stock Option”
means an Option other than an Incentive Stock Option.

“Option” means the right to purchase Common Stock
granted under Section 6.

“Option
Expiration Date”
means the last day of the maximum term of the Option.

“Participant” means the person to whom an Award is
granted.

“Plan” means the Poniard Pharmaceuticals, Inc.
Amended and Restated 2004 Incentive Compensation Plan.

“Plan
Administrator”
means the administrator of the Plan as set forth in Section 9.

“Related
Corporation”
means (a) when referring to a subsidiary corporation, any corporation
(other than the Company) in, at the time of the granting of the Option, an
unbroken chain of corporations ending with the Company, if stock possessing 50%
or more of the total combined voting power of all classes of stock of each of
the corporations other than the Company is owned by one of the other
corporations in such chain, and (b) when referring to a parent
corporation, any corporation in an unbroken chain of corporations ending with
the Company if, at the time of the granting of the Option, each of the
corporations other than the Company 

 

owns
stock possessing 50% or more of the total combined voting power of all classes
of stock in one of the other corporations in such chain.

“Restricted
Stock” means an
Award of shares of Common Stock granted under Section 8, the rights of
ownership of which may be subject to restrictions prescribed by the Plan
Administrator.

“Retirement” means, unless otherwise defined by the
Plan Administrator from time to time for purposes of the Plan or set forth in
the Award agreement, retirement as an employee from the Employer on or after
age 65.”

“Section 409A” means Section 409A of the Code,
including any proposed and final regulations and other guidance issued
thereunder by the Department of the Treasury and/or the Internal Revenue
Service.

“Securities
Act” means the
Securities Act of 1933, as amended.

“Stock
Unit” means an
Award granted under Section 8 denominated in units of Common Stock.

“Substitute
Awards” means
Awards granted or shares of Common Stock issued by the Company in assumption
of, or in substitution or exchange for, awards previously granted by a company
acquired by the Employer or with which the Employer combines.

“Ten
Percent Shareholder”
means an employee who owns more than 10% of the total combined voting power of
all classes of stock of the Company or any Related Corporation. The
determination of more than 10% ownership shall be made in accordance with Section 422
of the Code.

“Termination of Service” means a termination of
employment or service relationship with the Employer for any reason, whether
voluntary or involuntary, including by reason of death, Disability or
Retirement. Any question as to whether and when there has been a Termination of
Service for the purposes of an Award and the cause of such Termination of
Service shall be determined by the Plan Administrator, whose determination
shall be conclusive and binding. Transfer of a Participant’s employment or service
relationship between the Company and any Related Corporation shall not be
considered a Termination of Service for purposes of an Award. Unless the Plan
Administrator determines otherwise, a Termination of Service shall be deemed to
occur if the Participant’s employment or service relationship is with an entity
that has ceased to be a Related Corporation.

“Total Disability” means unless otherwise
defined by the Plan Administrator or set forth in the Award agreement, a mental
or physical impairment of the Participant that is expected to result in death
or that has lasted or is expected to last for a continuous period of 12 months
or more and which causes the Participant to be unable, in the opinion of the
Company, to perform his or her duties for the Company and to be engaged in any
substantial gainful activity. Total Disability shall be deemed to have occurred
on the first day after the Company has furnished its opinion of Total
Disability to the Plan Administrator. Notwithstanding the foregoing, “Total
Disability,” for purposes of Awards subject to Section 409A, has the
meaning given such term under Section 409A.

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