Document:

<PAGE>

                                                                   EXHIBIT 10.41
                       THIRD LOAN MODIFICATION AGREEMENT

      This Third Loan Modification Agreement is entered into as of June 25,
2002, by and between Inktomi Corporation (the "Borrower") and Silicon Valley
Bank ("Bank").

      1.    DESCRIPTION OF EXISTING INDEBTEDNESS. Among other indebtedness which
may be owing by Borrower to Bank, Borrower is indebted to Bank pursuant to,
among other documents, an Amended and Restate Loan and Security Agreement, dated
February 16, 2001, as amended by that certain Loan Modification Agreement, dated
as of September 30, 2001, that certain Loan Modification Agreement, dated as of
December 19, 2001 and as may be amended from time to time, (the "Loan
Agreement"). Defined terms used but not otherwise defined herein shall have the
same meanings as in the Loan Agreement.

      Hereinafter all indebtedness owing by Borrower to Bank shall be referred
to as the "Indebtedness."

      2.    DESCRIPTION OF COLLATERAL AND GUARANTIES.  Repayment of the
Indebtedness is secured by the Collateral as described in the Loan Agreement
and Intellectual Property Security Agreement.

Hereinafter, the above-described security documents and guaranties, together
with all other documents securing repayment of the Indebtedness shall be
referred to as the "Security Documents". Hereinafter, the Security Documents,
together with all other documents evidencing or securing the Indebtedness shall
be referred to as the "Existing Loan Documents."

      3.    DESCRIPTION OF CHANGE IN TERMS:

            A.    Modification(s) to Loan Agreement.

                  (1)   The following defined terms under Section 1.1 entitled
"Definitions" are added to read as follows:

                  "`Credit Extension' means each Advance, Equipment Advance,
      Letter of Credit, Second Equipment Advance, or any other extension of
      credit by Bank for the benefit of Borrower hereunder.

                  `Funding Date' is any date on which a Second Equipment Advance
            is made to or on account of Borrower.

                  `Repayment Period' as to the Second Equipment Advances, is 36
      months.

                  `Scheduled Payments' is defined in Section 2.1.5(c)

                  `Second Committed Equipment Line' means a credit
      extension of up to Six Million Dollars ($6,000,000.00)

                                       1
<PAGE>
                  `Second Equipment Advance' has the meaning set forth in
      Section 2.1.5.

                  `Second Equipment Availability End Date' means
      December 20, 2002.

                  (2)   The following Section 2.1.5 is hereby added
immediately following Section 2.1.4:

                 "2.1.5 Second Equipment Advances.

                        (a)   Subject to and upon the terms and conditions of
      this Agreement, at any time commencing on June 21, 2002 through the Second
      Equipment Availability End Date, Bank agrees to make advances (each a
      "Second Equipment Advance" and, collectively, the Second Equipment
      Advances") not exceeding the Second Committed Equipment Line. To evidence
      the Second Equipment Advance or Second Equipment Advances, Borrower shall
      deliver to Bank, at the time of each Second Equipment Advance request, an
      invoice for the Equipment to be purchased. The Second Equipment Advances
      shall be used only to purchase or refinance Equipment acceptable to Bank,
      purchased on or after ninety (90) days prior to June 21, 2002, and shall
      not exceed one hundred percent (100%) of the invoice amount of such
      equipment approved from time to time by Bank, excluding taxes, shipping,
      warranty charges, freight discounts and installation expense, provided,
      however, that software, taxes, shipping and other "soft cost", acceptable
      to Bank, may constitute up to 25% of each Second Equipment Advance. Each
      Second Equipment Advance shall be in an amount of no less than $500,000.
      The maximum number of Second Equipment Advances may not exceed 10.

                        (b)   To obtain a Second Equipment Advance, Borrower
      must notify Bank (the notice is irrevocable) by facsimile no later than
      12:00 noon. Pacific time two (2) Business Day before the Funding Date. The
      notice in the form of Exhibit B (Payment/Advance Form) must be signed by a
      Responsible Officer or designee and include a copy of the invoice for the
      Equipment being financed.

                        (c)   Borrower shall repay each Second Equipment Advance
      in 36 equal monthly installments of principal plus accrued interest as of
      the Payment Date. Each monthly payment for each Second Equipment Advance
      (collectively, "Scheduled Payments") shall be due an payable on the
      Payment Date following the Funding Date with respect to such Second
      Equipment Advance and continuing thereafter during the Repayment Period on
      each Payment Date. All unpaid principal and accrued interest is due and
      payable in full on the last Payment Date with respect to such Second
      Equipment Advance. Payments received after 12:00 noon Pacific time are
      considered received at the opening of business on the next Business Day.
      An Equipment Advance may only be prepaid in accordance with Section 2.1.5
      (f) and 2.1.5 (g).

                                       2
<PAGE>
                         (d)   Borrower will pay interest on the Payment Dates
      at the per annum rate of interest set forth in Section 2.3 (a).

                         (e)   At any time, provided no Event of Default has
      occurred and is continuing, Borrower may prepay any Second Equipment
      Advance by providing Bank with written notice two (2) days prior to any
      such prepayment and immediately paying to Bank: (i) all outstanding
      principal to the Second Equipment Advance being prepaid, (ii) all accrued
      unpaid interest for the Second Equipment Advance being prepaid, to the
      date of the prepayment, and (iii) all other sums, if any, that shall have
      become due and payable with respect to the Second Equipment Advance being
      prepaid.

                         (f)   If the Second Equipment Advances are accelerated
      following the occurrence of an Event of Default, then Borrower will
      immediately pay to Bank (i) all outstanding principal with respect to all
      Second Equipment Advances, (ii) all accrued unpaid interest with respect
      to all Second Equipment Advances, including the default rate of interest,
      to the date of the prepayment, and (iii) all other sums, if any, that
      shall have become due and payable with respect to any Second Equipment
      Advance."

                  (3)    Section 2.3 (a) is hereby amended by adding the
      following subsection (iii), immediately after subsection (ii):

                  "(iii) Second Equipment Advances. Except as set forth in
      Section 2.3(b), the Second Equipment Advances shall bear interest on the
      average daily balance thereof, at a per annum rate equal to the Prime Rate
      plus 35 basis points."

                  (4)    Section 2.3 (c) is hereby amended to read as follows:

                  "(c)   Payment. Interest hereunder shall be due and payable on
      each Payment Date. Bank shall, at its option, charge such interest, all
      Bank Expenses, and all Periodic Payments against any of Borrower's deposit
      accounts, or against the Committed Revolving Line, the Committed Equipment
      Line, or the Second Committed Equipment Line in which case those amounts
      shall thereafter accrue interest at the rate then applicable hereunder.
      Bank will notify Borrower of all debits which Bank has made against
      Borrower's account. Any such debits against Borrower's accounts in no way
      shall be deemed a set-off. Any interest not paid when due shall be
      compounded by becoming a part of the Obligations, and such interest shall
      thereafter accrue interest at the rate then applicable hereunder."

                  (5)    Section 2.7 is hereby amended to read as follows:

                  "2.7   Term. This Agreement shall become effective on the
      Closing Date and, subject to Section 12.7, shall continue in full force
      and effect until all of the Credit Extensions have been paid in full in
      immediately available funds. Notwithstanding the foregoing, Bank shall
      have the right to terminate its

                                       3
<PAGE>
      obligation to make Credit Extensions under this Agreement immediately and
      without notice upon the occurrence and during the continuance of an Event
      of Default. Notwithstanding termination, Bank's Lien on the Collateral
      shall remain in effect for so long as any Obligations (excluding
      Obligations under Section 2.6 and 12.2 to the extent they remain inchoate
      at the time outstanding payment obligations are paid in full and other
      Obligations that have been collateralized in a manner satisfactory to
      Bank) are outstanding."

                  (6)    The first sentence of Section 6.8 is hereby amended to
read as follows:

                  "Borrower shall maintain, on a monthly basis, a balance of
      unrestricted cash, unrestricted short term cash equivalents and
      unrestricted short term investments as defined by GAAP in an amount of not
      less than the sum of (a) 3.5 times the Commitment Amount, plus (b) any
      Additional Required Cash Balance."

                  (7)    Article 6 is hereby amended by adding the following
Sections 6.11 and 6.12:

                  "6.11  Profitability. Borrower's net losses for each of the
      following quarters set forth below shall not exceed the amounts set forth
      immediately opposite to such quarters:

                  Quarter Ending                Net Loss

                  June 30, 2002                 ($36,963,000)

                  September 30, 2002            ($36,545,000)

                  December 31, 2002             ($32,000,000)

                  March 31, 2003                ($22,000,000)

                  June 30, 2003 and every

                  every quarter thereafter      ($15,000,000)

                  6.12   Minimum Deposits. Borrower shall maintain at all times,
      no less than $6,000,000 in cash deposits at Bank or one of Bank's
      affiliates.

                  6.13   Additional Collateral. Upon the occurrence of an Event
      of Default arising out of Borrower's violation of Section 6.8 or Section
      6.11, Borrower shall (at Borrower's option) maintain either of the
      following (the "Collateral Deposits"): (i) a certificate of deposit at
      Bank in a minimum amount equivalent to the aggregate amount of Second
      Equipment Advances; or (ii) investments maintained in investment accounts
      at the Bank or one of its affiliates in a minimum amount equivalent to
      115% of the aggregate amount of

                                       4
<PAGE>
      Second Equipment Advances. Borrower acknowledges and agrees that Bank will
      place a "hold" in such Collateral Deposits until no Second Equipment
      Advances are available for borrowing under the Second Committed Equipment
      Line and all outstanding Second Equipment Advances have been paid in full
      in immediately available funds. In connection with the Collateral
      Deposits, Borrower agrees to deliver to Bank control agreement(s) in form
      and substance satisfactory to Bank.

                  Bank agrees that upon Borrower's fulfillment of the
      requirements under this Section 6.13, any existing Events of Default
      arising out of Borrower's violation such Sections shall be considered
      cured as follows: (i) with respect to Section 6.11, such violation shall
      be considered cured and the covenant set forth therein shall be deleted in
      its entirety, and (ii) with respect to Section 6.8, the violation shall be
      considered cured (to the extent that the violation is the result of the
      amounts outstanding under the Second Equipment Advances) and the
      definition of Commitment Amount therein shall not include amounts
      outstanding under the Second Equipment Advances or any amounts available
      for borrowing under the Second Committed Equipment Line. Borrower
      understands and agrees that, after the fulfillment of the requirements in
      this Section 6.13, the covenant set forth in Section 6.8 will continue to
      be effective and calculated in accordance with the revised definition of
      Committed Amount set forth above."

                  (8)    Article 7 is hereby amended by adding the following
Section 7.14:

                  "7.14  Negative Pledge. Create, grant to or agree with any
      other Person to a negative pledge or other restriction on the granting of
      security interests in, or Liens against, any of Borrower's Intellectual
      Property."

                  (9)    Section 8.3 is hereby amended to read as follows:

                  "8.3   Material Adverse Change.

                  If there (i) occurs a material adverse change in the business
      operations, or condition (financial or otherwise) of the Borrower; or (ii)
      is a material impairment of the prospect of repayment of any portion of
      the Obligations; or (iii) is a material impairment of the value or
      priority of Bank's security interests in the Collateral."

      4.    CONSISTENT CHANGES. The Existing Loan Documents are hereby amended
wherever necessary to reflect the changes described above.

      5.    NO DEFENSES OF BORROWER. Borrower (and each guarantor and pledgor
      signing below) agrees that, as of the date hereof, it has no defenses
      against the obligations to pay any amounts under the Indebtedness.

      6.    PAYMENT OF LOAN FEE.  Borrower shall pay Bank, no later than
June 21, 2002, a fee in the amount of Sixty Thousand and 00/100 Dollars
($60,000) ("Loan Fee") plus all out-of-pocket expenses.

                                       5
<PAGE>
      7.    CONTINUING VALIDITY. Borrower (and each guarantor and pledgor
signing below) understands and agrees that in modifying the existing
Indebtedness, Bank is relying upon Borrower's representations, warranties, and
agreements, as set forth in the Existing Loan Documents. Except as expressly
modified pursuant to this Third Loan Modification Agreement, the terms of the
Existing Loan Documents remain unchanged and in full force and effect. Bank's
agreement to modifications to the existing Indebtedness pursuant to this Third
Loan Modification Agreement in no way shall obligate Bank to make any future
modifications to the Indebtedness. Nothing in this Third Loan Modification
Agreement shall constitute a satisfaction of the Indebtedness. It is the
intention of Bank and Borrower to retain as liable parties all makers and
endorsers of Existing Loan Documents, unless the party is expressly released by
Bank in writing. No maker, endorser, or guarantor will be released by virtue of
this Third Loan Modification Agreement. The terms of this paragraph apply not
only to this Third Loan Modification Agreement, but also to all subsequent loan
modification agreements.

      8.    CONDITIONS.  The effectiveness of this Third Loan Modification
Agreement is conditioned upon payment of the Loan Fee.

BORROWER:                                 BANK:

INKTOMI CORPORATION                       SILICON VALLEY BANK

By:    /s/ David Peterschmidt             By:    /s/
   -----------------------------------       -----------------------------------
Name:  David Peterschmidt                 Name:
     ---------------------------------         ---------------------------------
Title: CEO and President                  Title:
      --------------------------------          --------------------------------

                                       6
<PAGE>
[GRAPHIC]
                               SILICON VALLEY BANK

                       PRO FORMA INVOICE FOR LOAN CHARGES

BORROWER:               INKTOMI CORPORATION

LOAN OFFICER:

DATE:                   JUNE 21, 2002

                        LOAN FEE                     $60,000
                        DOCUMENTATION FEE          _________
                        LEGAL FEES                 _________

                        TOTAL FEE DUE              $
                                                    ========

PLEASE INDICATE THE METHOD OF PAYMENT:

      { } A CHECK FOR THE TOTAL AMOUNT IS ATTACHED.

      {X} DEBIT DDA # 3300023368 FOR THE TOTAL AMOUNT.

      { } LOAN PROCEEDS

BORROWER:

BY:________________________________________
    (AUTHORIZED SIGNER)

___________________________________________
SILICON VALLEY BANK, AS AGENT   (DATE)
ACCOUNT OFFICER'S SIGNATURE

                                       1
<PAGE>
                       FOURTH LOAN MODIFICATION AGREEMENT

      This Fourth Loan Modification Agreement is entered into as of July 31,
2002, by and between Inktomi Corporation (the "Borrower") and Silicon Valley
Bank ("Bank").

      1. Description of Existing Indebtedness. Among other indebtedness which
may be owing by Borrower to Bank, Borrower is indebted to Bank pursuant to,
among other documents, an Amended and Restated Loan and Security Agreement,
dated February 16, 2001, as amended by that certain Loan Modification Agreement,
dated as of September 30, 2001, that certain Loan Modification Agreement, dated
as of December 19, 2001, and that certain Third Loan Modification Agreement,
dated June __, 2002, (as the same may be further amended from time to time, the
"Loan Agreement"). Defined terms used but not otherwise defined herein shall
have the same meanings as in the Loan Agreement.

      Hereinafter all indebtedness owing by Borrower to Bank shall be referred
to as the "Indebtedness."

      2. Description of Collateral and Guaranties. Repayment of the
Indebtedness is secured by the Collateral as described in the Loan Agreement and
Intellectual Property Security Agreement.

      Hereinafter, the above-described security documents and guaranties,
together with all other documents securing repayment of the Indebtedness shall
be referred to as the "Security Documents". Hereinafter, the Security Documents,
together with all other documents evidencing or securing the Indebtedness shall
be referred to as the "Existing Loan Documents."

      3. Description of Change in Terms:

            A. Modification to Loan Agreement.

                  (1) Section 6.13 of the Loan Agreement is hereby amended to
read as follows:

                  "6.13 Additional Collateral. Upon the occurrence of an Event
      of Default arising out of Borrower's violation of Section 6.8 or Section
      6.11, Borrower shall (at Borrower's option) maintain either of the
      following and grant Bank a perfected security interest in the same (the
      "Collateral Deposits"): (i) a certificate of deposit at Bank in a minimum
      amount equivalent to the aggregate amount of Second Equipment Advances;
      (ii) investments made through the Bank or one of its affiliates in US
      Treasuries or US Treasury Funds, in a minimum amount equivalent to 100% of
      the aggregate amount of Second Equipment Advances or (iii) investments
      maintained in investment accounts at the Bank or one of its affiliates,
      other than those in subsection (ii) above, in a minimum amount equivalent
      to 115% of the aggregate amount of Second Equipment Advances. Borrower
      acknowledges and agrees that Bank will place a "hold" in such Collateral
      Deposits

                                       2
<PAGE>
      Bank agrees that upon Borrower's fulfillment of the requirements under
      this Section 6.13, any existing Events of Default arising out of
      Borrower's violation such Sections shall be considered cured as follows:
      (i) with respect to Section 6.11, such violation shall be considered cured
      and the covenant set forth therein shall be deleted in its entirety, and
      (ii) with respect to Section 6.8, the violation shall be considered cured
      (to the extent that the violation is the result of the amounts outstanding
      under the Second Equipment Advances) and the definition of Commitment
      Amount therein shall not include amounts outstanding under the Second
      Equipment Advances or any amounts available for borrowing under the Second
      Committed Equipment Line. Borrower understands and agrees that, after the
      fulfillment of the requirements in this Section 6.13, the covenant set
      forth in Section 6.8 will continue to be effective and calculated in
      accordance with the revised definition of Committed Amount set forth
      above."

      4. Consistent Changes. The Existing Loan Documents are hereby amended
wherever necessary to reflect the changes described above.

      5. Waiver and Consent.

            A. Waiver. Bank hereby waives, solely for fiscal quarter ending June
30, 2002, the Event of Default under Section 8.2 of the Loan Agreement as a
result of Borrower's failure to meet the minimum profitability covenant set
forth in Section 6.11 but only to the extent such Event of Default arose out of:
(i) non-cash charges resulting from the write-off of goodwill and (ii) non-cash
lease expenses, or other non-cash charges relating the Synthetic Lease
Transaction (the "Profitability Default").

            B. Consent. Notwithstanding Section 7.3 of the Loan Agreement, Bank
hereby consents to the acquisition by Borrower of all the capital stock of
Quiver, Inc., provided, however that Borrower shall not spend more than
$7,000,000 cash consideration in connection with such acquisition.

            C. Limitation. The waiver in paragraph A (the "Waiver") and consent
in paragraph B (the "Consent") of this Section 5 shall become effective only in
accordance with Section 8 hereof and then only in this specific instance and for
the specific purposes set forth herein. Neither the Waiver nor the Consent
allows for any other or further departure from the terms and conditions of the
Loan Agreement, as amended hereby, or any of the other Existing Loan Documents,
which terms and conditions shall remain in full force and effect.

      6. No Defenses of Borrower. Borrower (and each guarantor and pledgor
signing below) agrees that, as of the date hereof, it has no defenses against
the obligations to pay any amounts under the Indebtedness.

      7. Continuing Validity. Borrower (and each guarantor and pledgor signing
below) understands and agrees that in modifying the existing Indebtedness, Bank
is relying upon Borrower's representations, warranties, and agreements, as set
forth in the Existing Loan Documents. Except as expressly modified pursuant to
this Fourth Loan Modification Agreement, the terms of the Existing Loan
Documents remain unchanged and in full force and

                                       3
<PAGE>
effect. Bank's agreement to modifications to the existing Indebtedness pursuant
to this Fourth Loan Modification Agreement in no way shall obligate Bank to make
any future modifications to the Indebtedness. Nothing in this Fourth Loan
Modification Agreement shall constitute a satisfaction of the Indebtedness. It
is the intention of Bank and Borrower to retain as liable parties all makers and
endorsers of Existing Loan Documents, unless the party is expressly released by
Bank in writing. No maker, endorser, or guarantor will be released by virtue of
this Fourth Loan Modification Agreement. The terms of this paragraph apply not
only to this Fourth Loan Modification Agreement, but also to all subsequent loan
modification agreements.

      8. Conditions. The effectiveness of this Fourth Loan Modification
Agreement is conditioned upon receipt by Bank of a fully executed original of
the same.

BORROWER:                                 BANK:

INKTOMI CORPORATION                       SILICON VALLEY BANK

By:    /s/ Randy Gottfried                By:    /s/ Bradford Leahy
   -----------------------------------       -----------------------------------
Name:  Randy Gottfried                    Name:  Bradford Leahy
     ---------------------------------         ---------------------------------
Title: SVP and CFO                        Title: Vice President
      --------------------------------          --------------------------------

                                       4
<PAGE>
[GRAPHIC]
                               SILICON VALLEY BANK

                       PRO FORMA INVOICE FOR LOAN CHARGES

BORROWER:               INKTOMI CORPORATION

LOAN OFFICER:

DATE:                   JULY __, 2002

                        LOAN FEE                  $_________
                        DOCUMENTATION FEE          _________
                        LEGAL FEES                 _________

                        TOTAL FEE DUE             $
                                                   =========

PLEASE INDICATE THE METHOD OF PAYMENT:

      { } A CHECK FOR THE TOTAL AMOUNT IS ATTACHED.

      {X} DEBIT DDA # 3300023368 FOR THE TOTAL AMOUNT.

      { } LOAN PROCEEDS

BORROWER:

BY:_________________________________________
     (AUTHORIZED SIGNER)

____________________________________________
SILICON VALLEY BANK, AS AGENT     (DATE)
ACCOUNT OFFICER'S SIGNATURE

                                       5<PAGE>

                                                                   EXHIBIT 10.51

                    AMENDMENT TO LOAN AND SECURITY AGREEMENT

      This Amendment to Loan and Security Agreement (this "Agreement") is
entered into as of May 20, 2002, by and between COMERICA BANK-CALIFORNIA
("Bank") and PHARMCHEM, INC. (the "Borrower"), with reference to the following
facts:

      A. Borrower has borrowed funds from Bank pursuant to that certain Amended
and Restated Loan and Security Agreement by and between Bank and Borrower dated
as of May 15, 2000, as amended by an Amendment to Loan and Security Agreement
and Limited Waiver dated as of September 12, 2001, a Modification to Amended and
Restated Loan and Security Agreement dated as of May 25, 2001, and by an
Amendment and Forbearance dated as of March 1, 2002 (the "Loan Agreement").

      B. As of the date hereof, there is owing under the Loan Agreement a
principal amount of $3,305,343.99 together with accrued but unpaid interest and
costs of enforcement. Such amounts, plus accruing interest and costs and accrued
and accruing attorneys' fees and costs are hereinafter sometimes referred to
herein as the "Existing Debt."

      C. Borrower has asked Bank to amend certain provisions of the Loan
Agreement, and Bank has agreed, all on the terms set forth in this Agreement.

      NOW, THEREFORE, for good and valuable consideration, the parties agree as
follows:

      1. Defined Terms. Capitalized terms not otherwise defined herein shall
have the same meanings as set forth in the Loan Agreement.

      2. Acknowledgement of Liability. As of the date of this Agreement,
Borrower owes Bank an amount equal to the Existing Debt. Borrower reaffirms all
of its obligations under the Loan Agreement and hereby forever waives and
relinquishes any and all claims, offsets or defenses that Borrower may now have
with respect to the payment of sums due to Bank and the performance of other
obligations under the Loan Agreement. The security interests granted to Bank in
the Loan Agreement in the Collateral remain perfected, first priority liens.

      3. Amendments to Loan Agreement. The Loan Agreement is hereby amended as
follows:

            (a) The following defined terms in Section 1.1 are amended to read
as follows:

                  "Borrowing Base" means an amount equal to eighty percent (80%)
      of Eligible Accounts, as determined by Bank with reference to the most
      recent Borrowing Base Certificate delivered by Borrower.

                  "Committed Revolving Line" means a credit extension of up to
      Four Million Two Hundred Fifty Thousand Dollars ($4,250,000).

                  "Revolving Maturity Date" means June 30, 2002.

            (b) The second sentence of Section 4 of the Amendment and
Forbearance dated as of March 1, 2002 by and between Borrower and Bank is
deleted.

                                       1
<PAGE>

            (c) A new Section 6.17 is added to the Loan Agreement, which shall
read as follows:

                  6.17 Liquidity. Borrower shall maintain at all times a balance
of unrestricted cash of at least One Million Dollars ($1,000,000).

      4. Ratification by Borrower of Bank's First Priority Security Interest in
Collateral. Borrower hereby confirms and ratifies Bank's first priority lien and
security interest in and to all Collateral. Borrower shall execute such security
agreements, financing statements and other documents as Bank may from time to
time reasonably request to carry out the terms of this Agreement and the Loan
Agreement. Such liens and security interests shall secure all of the obligations
of Borrower under this Agreement and the Loan Documents.

      5. Representations and Warranties.

            (a) Borrower hereby represents and warrants that no Event of Default
or failure of condition has occurred or exists, or would exist with notice or
lapse of time or both under any of the Loan Agreement.

            (b) All representations and warranties of Borrower in this Agreement
and the other Loan Agreement are true and correct as of the date hereof, and
shall survive the execution of this Agreement.

      6. Default. In addition to all other Events of Default under the Loan
Agreement, the following shall constitute an Event of Default:

            (a) Borrower's failure to pay any amount when due under this
Agreement or to perform any covenant or other agreement contained in this
Agreement or any other document entered into pursuant hereto.

      7. Conditions Precedent. The effectiveness of this Agreement is subject to
receipt by Bank of the following, in each case in form and substance acceptable
to Bank:

            (a) This Agreement;

            (b) Payment of all Bank Expenses incurred in connection with this
Agreement; and

            (c) Such other documents and completion of such other matters as
Bank may reasonably deem necessary or appropriate.

      8. Release.

            (a) Borrower acknowledges that Bank would not enter into this
Agreement without Borrower's assurance that Borrower has no claims against Bank
or any of Bank's officers, directors, employees or agents. Except for the
obligations arising hereafter under this Agreement, Borrower releases Bank, any
person or entity that has obtained any interest from Bank under the Loan
Agreement and each of Bank's and entity's officers, directors and employees from
any known or unknown claims which Borrower now has against Bank of any nature,
including any claims that Borrower, its successors, counsel, and advisors may in
the future discover they would have now had if they had known facts not now
known to them, whether founded in contract, in tort or pursuant to any other
theory of liability,

                                       2
<PAGE>

including but not limited to any claims arising out of or related to the Loan
Agreement or the transactions contemplated thereby. Borrower waives the
provisions of California Civil Code section 1542, which states:

            A general release does not extend to claims which the creditor does
            not know or suspect to exist in his favor at the time of executing
            the release, which if known by him must have materially affected his
            settlement with the debtor.

            (b) The provisions, waivers and releases set forth in this section
are binding upon Borrower and Borrower's agents, employees, assigns and
successors in interest. The provisions, waivers and releases of this section
shall inure to the benefit of Bank and its agents, employees, officers,
directors, assigns and successors in interest.

            (c) Borrower warrants and represents that Borrower is the sole and
lawful owner of all right, title and interest in and to all of the claims
released hereby and Borrower has not heretofore voluntarily, by operation of law
or otherwise, assigned or transferred or purported to assign or transfer to any
person any such claim or any portion thereof. Borrower shall indemnify and hold
harmless Bank from and against any claim, demand, damage, debt, liability
(including payment of attorneys' fees and costs actually incurred whether or not
litigation is commenced) based on or arising out of any assignment or transfer.

            (d) The provisions of this Section shall survive payment in full of
the Obligations, full performance of all the terms of this Agreement and the
Loan Agreement, and/or Bank's actions to exercise any remedy available under the
Loan Agreement or otherwise.

      9. Further Assurances. Borrower will take such other actions as Bank may
reasonably request from time to time to perfect or continue Bank's security
interests in Borrower's property, and to accomplish the objectives of this
Agreement.

      10. Consultation of Counsel. Borrower acknowledges that Borrower has had
the opportunity to be represented by legal counsel of its own choice throughout
all of the negotiations that preceded the execution of this Agreement. Borrower
has executed this Agreement after reviewing and understanding each provision of
this Agreement and without reliance upon any promise or representation of any
person or persons acting for or on behalf of Bank. Borrower further acknowledges
that Borrower and its counsel have had adequate opportunity to make whatever
investigation or inquiry they may deem necessary or desirable in connection with
the subject matter of this Agreement prior to the execution hereof and the
delivery and acceptance of the consideration described herein.

      11. Miscellaneous.

            (a) Successors and Assigns. This Agreement shall be binding upon and
shall inure to the benefit of Borrower and Bank and their respective successors
and assigns; provided, however, that the foregoing shall not authorize any
assignment by Borrower of its rights or duties hereunder.

            (b) Integration. This Agreement and any documents executed in
connection herewith or pursuant hereto contain the entire agreement between the
parties with respect to the subject matter hereof and supersede all prior
agreements, understandings, offers and negotiations, oral or written, with
respect thereto and no extrinsic evidence whatsoever may be introduced in any
judicial or arbitration proceeding, if any, involving this Agreement; except
that any financing statements or other agreements or instruments filed by Bank
with respect to Borrower shall remain in full force and effect.

                                       3
<PAGE>

            (c) Entire Agreement. This Agreement and the Loan Documents contain
the entire agreement of the parties hereto and supersede any other oral or
written agreements or understandings with respect to the subject matter hereof
and thereof.

            (d) Course of Dealing; Waivers. No course of dealing on the part of
Bank or its officers, nor any failure or delay in the exercise of any right by
Bank, shall operate as a waiver thereof, and any single or partial exercise of
any such right shall not preclude any later exercise of any such right. Bank's
failure at any time to require strict performance by Borrower of any provision
shall not affect any right of Bank thereafter to demand strict compliance and
performance. Any suspension or waiver of a right must be in writing signed by an
officer of Bank.

            (e) Time is of the Essence. Time is of the essence as to each and
every term and provision of this Agreement and the Loan Documents.

            (f) Counterparts. This Agreement may be signed in counterparts and
all of such counterparts when properly executed by the appropriate parties
thereto together shall serve as a fully executed document, binding upon the
parties.

            (g) Legal Effect. The Loan Documents remain in full force and
effect. If any provision of this Agreement conflicts with applicable law, such
provision shall be deemed severed from this Agreement, and the balance of this
Agreement shall remain in full force and effect.

            (h) WAIVER OF JURY. BANK AND BORROWER ACKNOWLEDGE AND AGREE THAT THE
TIME AND EXPENSE REQUIRED FOR TRIAL BY JURY EXCEED THE TIME AND EXPENSE REQUIRED
FOR A BENCH TRIAL AND HEREBY WAIVE, TO THE EXTENT PERMITTED BY LAW, TRIAL BY
JURY OF ANY CLAIM OR CAUSE OF ACTION BASED UPON, RELATED TO OR ARISING OUT OF
THE TRANSACTIONS CONTEMPLATED BY THE LOAN AGREEMENT, INCLUDING CONTRACT CLAIMS,
TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW OR STATUTORY
CLAIMS. EACH PARTY RECOGNIZES AND AGREES THAT THE FOREGOING WAIVER CONSTITUTES A
MATERIAL INDUCEMENT FOR IT TO ENTER INTO THIS AGREEMENT. EACH PARTY REPRESENTS
AND WARRANTS THAT IT HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL AND THAT IT
KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION
WITH LEGAL COUNSEL.

            (i) Assignment. Borrower consents to Bank's assignment of all or any
part of Bank's rights under this Agreement and the Loan Agreement.

            (j) Power of Attorney. Borrower confirms that the irrevocable power
of attorney granted in the Loan Agreement remains in full force and effect

            (k) Choice of Law and Venue. This Agreement shall be governed by,
and construed in accordance with, the internal laws of the State of California,
without regard to principles of conflicts of law. Each of Borrower and Bank
submits to the exclusive jurisdiction of the state and Federal courts located in
the County of Santa Clara, State of California.

                                       4
<PAGE>

      IN WITNESS WHEREOF the undersigned have executed this Agreement as of the
first date above written.

                                        PHARMCHEM, INC.

                                        By:     /S/ DAVID A. LATTANZIO
                                                ----------------------

                                        Title:  Vice President & CFO
                                                ----------------------

                                        COMERICA BANK-CALIFORNIA

                                        By:     /S/ JAMES L. WEBER
                                                ----------------------

                                        Title:  First Vice President
                                                ----------------------

                                       5

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