Document:

EX-10.12

 Exhibit 10.12 

Duncan McHale 
 TERMS
AND CONDITIONS OF EMPLOYMENT 
 Employer’s name and address: Evelo Biosciences, Inc. of 620 Memorial Dr., Suite 200 West, Cambridge MA 02139
(the “Company”) 
 Employee’s name and address: Duncan McHale of Little Acres, The Hill, Littlebourne, Canterbury, Kent CT3 1TB
UK (the “Employee”) 
 In terms of the Employment Rights Act 1996 (the “Act”) this document gives details of your terms
and conditions of employment with the Company together with other workplace information, as at 15 December 2017 
  

	1.	JOB TITLE AND DUTIES 

  

	1.1	You are employed as Chief Medical Officer with effect from 15 December 2017. Your continuous employment started on this date. 

  

	1.2	You will perform all duties required of you by the board of directors of the Company (the “Board”). 

  

	1.3	Whilst employed by the Company you must: 

  

	 	(a)	during your hours of work devote all of your time, attention and abilities to the business of the Company and carry out your duties with due care and attention; 

 

	 	(b)	not, without the Company’s prior written consent, be in any way directly or indirectly engaged or concerned with any other business or employment (with the exception of Weatherden Limited) whether during or outside
your hours of work for the Company; 

  

	 	(c)	use your best efforts to promote and protect the interests of the Company and its subsidiaries and affiliates (each a “Group Company” and together the “Group”) and observe the utmost good faith
towards the Company and the Group; and 

  

	 	(d)	comply with all the Company’s rules, regulations and policies from time to time in force and any rules which the Company’s clients may require you to observe whilst working on their premises.

  

	2.	COMMENCEMENT OF EMPLOYMENT 

  

	2.1	Your period of continuous employment with the Company commenced on 15 December 2017. 

  

	2.2	No employment with a previous employer counts as part of your period of continuous employment with the Company. 

  

	3.	REMUNERATION 

  

	3.1	Your gross basic salary is £225,000 per annum (or such other sum as agreed from time to time). The salary will be paid after deduction of all taxes and national insurance contributions and is payable in equal
monthly instalments into your nominated bank account on or around the last working day of each month. 

  

	3.2	Your salary will be reviewed at regular intervals. 

 WRITTEN TERMS (LONG) 

  
 1 

	3.3	For the purposes of the Employment Rights Act 1996, sections 13-27, you agree that the Company may deduct from your remuneration any sums due from you to the Company including,
without limitation, your pension contributions (if any) and any overpayments, loans or advances made to you by the Company. 

  

	3.4	The Company may, at its absolute discretion pay you an annual, performance-based bonus upon the achievement of certain performance goals determined by the Board from time to time (the “Bonus”). The
terms and amount of this Bonus (and whether it is paid in cash or in other forms, such as shares or share options) will be approved from time to time and notified to you by the Board in its sole discretion. In determining whether a bonus is to be
paid, and if so the size of that bonus the Board may take into account such factors as it considers, in its absolute discretion, to be appropriate, which may include the anticipated future performance or service and/or past performance of you and/or
the Company and/or the Group, although it has no obligation to take any of these factors into account. The bonus will not accrue, nor will you have any legitimate expectation as to the size or form of the discretionary bonus, until the Company pays
it to you. There are no circumstances whether in reliance on express or implied terms or otherwise where you can require pay out of a particular sum or payment in a particular form or claim compensation for loss of such a bonus. Upon the termination
of your employment or (if earlier) upon either party giving notice of termination you will have no rights as a result of this Agreement or any alleged breach of it to any compensation under or in respect of any bonus scheme. 

 

	4.	EXPENSES 

 The Company shall reimburse to you (against receipts or other appropriate
evidence as the Company may require) the amount of all out-of-pocket expenses reasonably and properly incurred by you in the proper performance of your duties hereunder
in accordance with the Company’s expenses policy in force from time to time. 
  

	5.	NORMAL HOURS OF WORK 

  

	5.1	You will be expected to work a minimum of 28 hours per week (being 75% of the minimum hours of a full time employee of the Company). 

 

	5.2	You may from time to time be required to work additional hours in order to properly perform your duties and/or allow the Company to meet its obligations to its clients. You are not entitled to additional remuneration
for authorised hours worked in excess of your normal hours.  

  

	5.3	In particular, you agree to work hours that exceed the maximum average weekly working time limit of 48 hours imposed by the Working Time Regulations 1998. You may withdraw your agreement on giving to the Company 3
months’ prior written notice. 

  

	6.	PLACE OF WORK 

  

	6.1	Your normal place of work will be Little Acres, The Hill, Littlebourne, Canterbury England but the Company may change your normal place of work on giving you at least one month’s notice of any permanent change to
your normal place of work. 

  

	6.2	You may be required to work at any of the Company’s premises or at the premises of its customers, clients, suppliers or associates around the world from time to time. 

 

	6.3	You may be required to work overseas for periods exceeding one month, however there are currently no particulars to be entered in this regard. 

	7.	NOTICE 

  

	7.1	The length of prior written notice that you must give the Company in order to terminate your employment is 3 months. 

  

	7.2	The Company must give you 3 months’ notice to terminate your employment.  

  

	7.3	The Company reserves the right in its absolute discretion to terminate your employment immediately either instead of or at any time after notice of termination is given by either party and to make a payment in lieu of
notice. For this purpose, pay in lieu of notice will be a sum equal to only your salary that you would have received during the period of notice outstanding on the termination of your employment. For the avoidance of doubt, the Company’s right
to make a payment in lieu of notice does not give you a right to receive such a payment in lieu of notice. 

  

	7.4	The Company may, at its absolute discretion, require you not to attend at work and/or not to undertake all or any of your duties hereunder during any period of notice (whether given by the Company or you), provided
always that the Company shall continue to pay your salary and contractual benefits. For the avoidance of doubt, there is no obligation on the Company to provide you with any work during any period of notice and you will not be entitled to work on
your own account or on account of any other person, firm or company during that period. 

  

	7.5	The Company may, notwithstanding any other terms of your employment and irrespective of whether the grounds for termination arose before or after your employment began, at any time by notice in writing, terminate your
employment with immediate effect and without compensation if:- 

  

	 	(a)	if you are convicted of a criminal offence other than one which in the opinion of the Board does not affect your position as an employee of the Company, bearing in mind the nature of your duties and the capacity in
which you are employed; 

  

	 	(b)	you are guilty of any serious default or misconduct in connection with or affecting the business of the Group, commit any serious or repeated breach of your obligations under your employment, are guilty of serious
neglect or negligence in the performance of your duties or behave in a manner (whether on or off duty) which is likely to bring the Group into disrepute or which seriously impairs your ability to perform your duties; 

 

	 	(c)	in the reasonable opinion of the Company, you have failed to substantially perform your duties to the Company (other than such failure resulting from any material illness that you are suffering) (provided that, to the
extent such failure can be cured, the Company shall have provided you with at least 30 days’ notice of such failure and you have not remedied the failure in the 30-day period); 

 

	 	(d)	in the reasonable opinion of the Company, you have failed in any material respect to carry out or comply with any lawful and reasonable directive of the Board consistent with the terms of this Agreement (provided that
to the extent such failure can be cured, the Company shall have provided you with at least 30 days’ notice of such failure and you have not remedied the failure in the 30-day period); 

 

	 	(e)	you are found to be using or under the influence of, or in possession of illegal drugs on the Company’s (or any Group Company’s) premises or while performing your duties under this Agreement;

  

	 	(f)	you do not have the right to work in the UK or you lose the right to work in the UK; 

	 	(g)	you are found guilty of misconduct by any applicable regulatory body or tribunal or any successor bodies. 

  

	8.	HOLIDAYS AND HOLIDAY PAY 

  

	8.1	You are entitled, to 21 days’ paid holiday in each holiday year (inclusive of all customary and public holidays recognised by the Company). 

 

	8.2	The Company’s holiday year runs from 1st January to 31st December. 

  

	8.3	If your employment begins or ends part way through the holiday year your holiday entitlement for that year will be assessed on a pro rata basis. 

 

	8.4	On termination of your employment you will be entitled to pay in lieu of any holidays which have accrued to you in the holiday year in which the termination takes place but which you have not taken at that time. The
Company may require you to take unused holidays during your notice period. If on the termination of your employment, you have taken holidays in excess of the statutory holiday entitlement which has accrued to you at that time you will be required to
repay to the Company holiday pay in respect of those holidays. 

  

	8.5	Holidays must be taken at times agreed by the Company and sufficient notice of a request to take holiday must be given to the Company. 

 

	8.6	All holidays must be taken in the holiday year in which they accrue and cannot be carried over to the next holiday year without the prior consent of the Company. 

 

	9.	SICKNESS OR OTHER ABSENCE 

  

	9.1	If you are absent from work for any reason and your absence has not previously been authorised by the Company you must inform the Company by 9am on your first day of absence. 

 

	9.2	In respect of absence due to sickness, injury or accident that continues for more than 7 consecutive days (including weekends) you must provide the Company with a medical certificate stating the reason for the absence.
Thereafter medical certificates must be provided to the Company to cover the remainder of the period of continuing sickness absence. Failure to follow these requirements may result in disciplinary action and loss of Statutory Sick Pay and company
sick pay. 

  

	9.3	If you are absent from work due to sickness, injury or accident and comply with the requirements in this Clause you will be paid: 

  

	 	(a)	Statutory Sick Pay in accordance with the provisions of the applicable legislation. For the purposes of Statutory Sick Pay, the “qualifying days” are Monday to Friday inclusive; and 

 

	 	(b)	At the discretion of the Board, Company sick pay equal to full salary for the first 2 weeks’ of absence due to sickness or injury in each calendar year. 

 

	9.4	Payment of Company sick pay shall be made less an amount equivalent to any Statutory Sick Pay payable to you. 

  

	9.5	The Company reserves the right to require you to undergo a medical examination conducted by a doctor nominated by the Company, at the Company’s expense. 

 

	9.6	If the sickness, injury or accident is caused by the act or omission of a third party you must, at the Company’s request, include in any claim for damages against such third party a claim in respect of moneys paid
by the Company under this Clause 9.6 and must refund to the Company any damages recovered under that head. 

	10.	PENSION ARRANGEMENTS AND OTHER BENEFITS 

  

	10.1	Pensions arrangements  

  

	 	(a)	During the period of your employment with the Company, the Company will comply at all times with the employer duties under Part 1 of the Pensions Act 2008. 

 

	 	(b)	You are eligible to join the group personal pension scheme initiated by the Company (the “Scheme”) subject to its rules from time to time in force. Details of the Scheme are available from
the Company. If you contribute a sum equivalent to at least 1% of his basic salary annually to the Scheme, then the Company will make an annual contribution to the Scheme of an amount equal to 1% of your basic salary. The contribution shall be paid
to the Scheme at such time or times during each year as the Company shall decide at its discretion. 

  

	10.2	Company’s right to terminate pensions arrangements 

 The
Company shall be entitled at any time to terminate the Scheme or your membership of it subject to providing him with membership of an equivalent pension scheme, the benefits of which shall be materially the same as the benefits provided to you under
the Scheme. 
  

	10.3	Other Benefits 

 You will receive a payment of £10,000 per annum in lieu of any
private medical and dental expenses insurance, permanent health assurance and life assurance arrangements. This will be paid monthly and will be subject to deductions and appropriate taxation. 

 

	11.	CONFIDENTIALITY 

 You must not (except in the proper performance of your duties) while
employed by the Company or at any time (without limit) after the date on which your employment with the Company terminates: 
  

	 	(a)	divulge or communicate to any person; 

  

	 	(b)	use for your own purposes or for any purposes other than those of the Company or, as appropriate, any of its clients; or 

  

	 	(c)	through any failure to exercise due care and diligence, cause any unauthorised disclosure of; 

any trade secrets or confidential information relating to the Company or any Group Company or any of its clients. You must at all times use
your best endeavours to prevent publication or disclosure of any trade secrets or confidential information. These restrictions shall cease to apply to any information which shall become available to the public generally otherwise than through the
default by you. 
  

	12.	DATA PROTECTION 

 By signing this Statement, you acknowledge and agree that the Company
is permitted to hold and process personal (and sensitive) information and data about you as part of its personnel and other business records; and may use such information in the course of the Company’s business. You agree that the Company may
disclose such information to third parties, including where they are situated outside the European Economic Area, in the event that such disclosure is in the Company’s view required for the proper conduct of the Company’s business or that
of any associated company. This Clause applies to information held, used or disclosed in any medium. 

	13.	COMPANY AND CLIENT PROPERTY 

 All equipment (including computer equipment), notes,
memoranda, records, lists of customers, suppliers and employees, correspondence, computer and other discs or tapes, data listings, codes, keys and passwords, designs, drawings and other documents or material whatsoever (whether made or created by
you or otherwise and in whatever medium or format) relating to the business of the Company or a group company or any of its or their clients (and any copies of the same) shall: 

 

	 	(a)	be and remain the property of the Company or the relevant client; and 

  

	 	(b)	be handed over by you to the Company on demand and in any event on the termination of your employment. 

  

	14.	GRIEVANCE AND DISCIPLINARY MATTERS 

  

	14.1	If you have any grievance relating to your employment you may apply in writing to any director of the Company. 

  

	14.2	The director will consider your grievance and report to you within 7 days of the date when the grievance was raised. 

  

	14.3	If that report is not acceptable to you, you may then, within 7 days of receipt by you of the report, refer the matter in writing to CEO who will notify you of their decision within 14 days and whose decision will be
final and binding. 

  

	14.4	The disciplinary rules applicable to you are contained in the staff handbook. 

  

	14.5	If you are dissatisfied with any decision of the Company regarding any disciplinary matter, you may apply in writing to the CEO within 5 days of the decision to have that decision
re-considered in accordance with the Company’s appeals procedure. The appeals procedure is set out in full in the staff handbook. 

 

	14.6	The grievance, disciplinary and appeals procedures are not contractually binding on the Company and the Company may alter them, or omit any or all of their stages where it considers it appropriate. 

 

	15.	COLLECTIVE AGREEMENTS 

 There are no collective agreements applicable to you or which
affect your terms of employment. 
  

	16.	CHANGES TO TERMS OF EMPLOYMENT 

  

	16.1	The Company reserves the right to make changes to any of your terms and conditions of employment. 

  

	16.2	You will be given not less than one month’s written notice of any significant changes that may be given by way of an individual notice. Such changes will be deemed to be accepted unless you notify the Company of
any objection in writing before the expiry of the notice period. 

	17.	PREVIOUS CONTRACTS 

 The contractual terms in this Statement shall be in substitution for
all or any existing contracts of employment entered into between you and the Company which cease to have effect on the date upon which you commence work under this Statement. 
  

	18.	CONDITIONS TO EMPLOYMENT AND CONTINUED EMPLOYEMNT 

  

	18.1	It is a condition of your employment with the Company that you are and remain legally entitled to reside and work in the United Kingdom. You confirm that you are legally entitled to work in the United Kingdom without
holding a work permit. Should it be discovered that you do not have permission to live and work in the United Kingdom or if any such permission is revoked, the Company reserves the right to terminate your employment forthwith without notice or pay
in lieu of notice and without referring to the warning stages of the Company’s disciplinary procedure. 

  

	19.	PRIVACY OF COMMUNICATION 

  

	19.1	All communications, whether by telephone, email, fax, or any other means, which are transmitted, undertaken or received using the Company’s IT or communications systems (“Company Systems”) or on
Company premises will be treated by the Company as work related. The Company Systems are provided for your work use only. You agree that the Company may intercept, record and monitor all communications made by you and your use of the Company Systems
without further notice. You should not regard any communications or use as being private. 

  

	19.2	The interception, recording and monitoring of communications is intended to protect the Company’s business interests for example, for the purposes of quality control, security of the Company Systems, protection of
the Company’s confidential information and legitimate business interests, record-keeping and evidential requirements, detection and prevention of criminal activity or misconduct and to assist the Company to comply with relevant legal
requirements. 

  

	19.3	You acknowledge and agree that all communications, data, records and files stored on the Company Systems or on the Company’s premises may be used as evidence in disciplinary or legal proceedings against you.

  

	20.	GOVERNING LAW AND JURISDICTION 

 This Statement is governed by and to be construed in
accordance with English law and any dispute is subject to the non-exclusive jurisdiction of the English courts. 

 IN WITNESS of which this Agreement has been executed and delivered as a deed on the first date
written above. 
  

					
	EXECUTED as a Deed	 	 /s/ Balkrishan S. Gill
	 	
	by EVELO BIOSCIENCES,	 	Director	 	
	INC. acting by Balkrishan S. Gill	 		 	
	 [Director]
 and Jennifer
Glennon[Director/
	 		 	
	Secretary]	 	 /s/ Jennifer Glennon
	 	
		 	Director/Secretary	 	
			
	 EXECUTED as a Deed
 by DUNCAN
MCHALE
	 	 /s/ Duncan McHale
	 	
	in the presence of:	 		 	
			
	Witness’s	 		 	
			
	Signature:	 	  
	 	
			
	Full Name:	 	  
	 	
			
	Address:	 	  
	 	
			
		 	  
	 	
			
		 	  
	 	

 Evelo Biosciences, Inc. 

620 Memorial Dr. 
 Suite 200 West

 Cambridge MA 02139 
 16 April 2018 

Duncan McHale 
 XXXXX 

United Kingdom 
 Dear Duncan, 

Amendment to Employment Agreement 
  

	1.	BACKGROUND 

  

	1.1	In consideration of your continued employment and an increase to your salary pursuant to clause 3.1 of your contract of employment dated 15 December 2017 (the “Employment Agreement”) with Evelo
Biosciences, Inc. (the “Company”) to £300,000 per annum with effect from 16 April 2018 (less deduction of all applicable income tax, National Insurance contributions and other withholdings), you agree to the changes to
your terms and conditions as set out in this side letter (the “Letter”). 

  

	1.2	This Letter shall take effect on 16 April 2018, provided that you sign and return a copy of this Letter to the Company. 

  

	1.3	By signing the enclosed copy of this Letter, you hereby agree to the amendments to your Employment Agreement and your terms and conditions of employment as set out in Clauses 2, 3 and 4 below. 

 

	1.4	Unless otherwise defined herein, all capitalised terms in this Letter are as defined in the Employment Agreement. 

  

	2.	CHANGES TO CLAUSE 3.1 OF THE EMPLOYMENT AGREEMENT 

  

	2.1	Clause 3.1 of the Employment Agreement shall be replaced with: “Your gross basic salary is £300,000 per annum (or such other sum as agreed from time to time). The salary will be paid after deduction of all
taxes and national insurance contributions and is payable in equal monthly instalments into your nominated bank account on or around the last working day of each month.” 

 

	3.	CHANGES TO CLAUSE 5 OF THE EMPLOYMENT AGREEMENT 

  

	3.1	Clause 5.1 of the Employment Agreement shall be replaced with: “You will be expected to work a minimum of 40 hours per week with such additional hours as are necessary for the performance of your duties.”

  

	4.	CHANGES TO CLAUSE 8.1 OF THE EMPLOYMENT AGREEMENT 

  

	4.1	Clause 5.1 of the Employment Agreement shall be replaced with: “You are entitled, to 28 days’ paid holiday in each holiday year (inclusive of all customary and public holidays recognised by the Company).”

  

	5.	GENERAL 

  

	5.1	If these changes are acceptable to you, please sign, date and return one copy of the Letter, appropriately witnessed. All other terms of your Employment Agreement shall remain unchanged and will continue in full force
and effect. 

	5.2	This Letter may be executed in any number of counterparts, and by the parties on separate counterparts, but shall not be effective until each of the parties has executed at least one counterpart. Each counterpart shall
constitute an original but all counterparts together shall constitute one and the same instrument. 

  

	5.3	This Letter is governed by and to be construed in accordance with English law and any dispute is subject to the exclusive jurisdiction of the English courts. 

If you have any questions about this letter, please do not hesitate to contact me. 

I look forward to working with you. 
  

	
	Yours sincerely
	
	 /s/ Balkrishan (Simba) Gill

	 Balkrishan (Simba) Gill, Ph.D.

	I,	Duncan McHale, acknowledge and agree that: 

  

	 	i.	I have read and understood the terms of this letter; and 

  

	 	ii.	I accept the amendments to my contract of employment stated in this letter. 

  

					
	Signature:	 	 /s/ Duncan McHale
	  	        Date: 29 April 2018EX-10.13

					
	

	  		  	Exhibit 10.13

 WEATHERDEN 

www.weatherden.co.uk 

DATED 
 1 January 2017 

 
  

Weatherden Limited 
 and 

Evelo Biosciences, Inc. 
  

AGREEMENT FOR THE SUPPLY OF SERVICES 
  

 

 

 
 WEATHERDEN 

www.weatherden.co.uk 

CONTENTS 
  

			
	1.	  	SUPPLY OF THE SERVICES
		
	2.	  	PAYMENT FOR THE SERVICES
		
	3.	  	CONFIDENTIALITY
		
	4.	  	ASSIGNMENT
		
	5.	  	TERMINATION
		
	6.	  	REPRESENTATIONS/INDEMNITY/LIMITATION OF LIABILITY
		
	7.	  	NOTICES
		
	8.	  	GENERAL

 SCHEDULE 1 - Description of the Services 

SCHEDULE 2 - Payment Schedule 

  

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

 THIS AGREEMENT is made on 1 January 2017 BETWEEN: 

 

	(1)	Weatherden Limited (UK registered company 09241011) whose registered office is at 93 Jack Straws Lane, Oxford, United Kingdom (“Weatherden”); and 

 

	(2)	Evelo Biosciences, Inc., a private company incorporated in Delaware USA with company offices at 620 Memorial Drive, Suite 200, Cambridge, MA 02139, United States (“Evelo”);

 each a “Party” and collectively the “Parties”. 

BACKGROUND 
  

	(A)	The agreement will initially cover the period of January 1st 2017 to December 31st 2018. 

  

	(B)	During the defined period Weatherden will act as early drug development consultants to Evelo providing support across their whole portfolio. 

 

	(C)	Specifically Weatherden will provide the equivalent of 20 hours per week of a designated senior drug developer’s time, Duncan McHale, and the equivalent of eight hours per week of a designated project manager and
up to the equivalent of eight hours per week of their executive chairman’s time, Houman Ashrafian. 

  

	(D)	Throughout the defined period of the agreement the commitment of each designated individual can be increased or decreased by mutual agreement in writing with the cost structure increased or decreased respectively in a pro-rated manner. Such commitments shall be subject to an initial quarterly allocation agreed to by the Parties and with any changes from the allocation in (C) documented in writing. 

 

	(E)	Additional core team members and or Weatherden Consultants may be added throughout this period. All additional personnel will be mutually agreed in writing between Weatherden and Evelo. 

 

	(F)	All reasonable business expenses incurred by Weatherden related to delivery of the Services defined in this agreement will be reimbursed by Evelo to Weatherden in addition to the support costs detailed in Annex 2. All
business expenses over $500 shall be approved in writing prior to commitment. 

  

	(G)	In the event that Evelo is not satisfied with the quality of support from a member of the Weatherden team then Weatherden then following notice to Weatherden and action to rectify Weatherden will make all reasonable
efforts to replace that member with another individual. Should Weatherden be unable to find a mutually 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

  

	 	acceptable additional resource then this will be taken as mutual agreement to reduce the support from the individual and the work program reduced accordingly. If any deliverables have been provided in part or whole by
such member, Weatherden shall promptly redo and/or rectify any errors in such deliverables at Weatherden’s expense to Evelo’s reasonable satisfaction. The overall work plan is detailed in Annex 1 and it is accepted that this plan will
evolve throughout the defined two year period by mutual agreement of both parties 

 NOW IT IS AGREED as follows: 

 

	 	1.	SUPPLY OF THE SERVICES 

  

	 	1.1	Within the constraints of the funding provided by Evelo under Clause 2, Weatherden shall use all reasonable endeavours to provide Evelo with the services and deliverables which are described in the First Schedule to
this Agreement (the “Services”). During the term of this Agreement and for 3 months following its termination, Weatherden shall not work with any other party in the field of immune-microbiome except with the express written
agreement of Evelo. Should Weatherden terminate the agreement prematurely then this period will be extended to 12 months. 

  

	 	1.2	Weatherden will use all reasonable endeavours to provide the Services in conformity with the timetable outlined in the Schedule 1. Evelo shall have the right to amend Schedule 1 as reasonably necessary and upon
Weatherden’s consent, not to be unreasonably withheld. 

  

	 	2.	PAYMENT FOR THE SERVICES 

  

	 	2.1	Evelo will make payment to Weatherden for the supply of the Services on the dates and in the amounts set out in this Agreement upon receipt of invoice referring to a relevant Purchase Order. Weatherden shall provide a
W9 form and invoice to the address provided under section 7.1. 

  

	 	2.2	For the Services outlined in Annex 1, compensation is agreed at $26,560 (USD) per month to cover the Weatherden core team support costs. 

 

	 	2.2.1	Within thirty days of receipt of invoice, Evelo will initiate payment for these Services 

  

	 	2.2.2	Payments shall be made to Weatherden via wire transfer 

  

	 	2.3	Additional payment terms for the partnership between Evelo and Weatherden will be detailed in a subsequent agreement. 

(a) All other payments to Weatherden will be made within 30 days of invoicing date. 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

 (b) Except as otherwise required by law, Evelo shall not withhold any sums or payments made to Weatherden for
social security or other federal, state or local tax liabilities, and all withholdings, liabilities, and contributions shall be solely Weatherden’s responsibility. 
  

	 	3.	CONFIDENTIALITY 

  

	 	3.1	This Agreement describes a business relationship between the parties under the November 1, 2016 Confidentiality Agreement between the parties and that Confidentiality Agreement shall apply to information exchanged
hereunder. All documents, information, and materials provided to Weatherden by or on behalf of Evelo are and shall remain the property and confidential information of Evelo. 

 

	 	3.2	Each party will use any Proprietary Information (as defined in the Confidentiality Agreement) disclosed in connection with the Services and use such information only for purposes of performing this Agreement. For
clarity, information generated by Weatherden in performing the Services for Evelo shall be Evelo’s Proprietary Information. 

  

	 	3.3	Neither party shall incur any obligation under Clause 3.2 with respect to information which, as evidenced by written records: 

  

	 	•	 	is known to the receiving party before the Effective Date, and not impressed already with any obligation of confidentiality to the disclosing party; or 

 

	 	•	 	is or becomes publicly known without the fault of the receiving party; or 

  

	 	•	 	is obtained by the receiving party from a third party in circumstances where the receiving party has no reason to believe that there has been a breach of an obligation of confidentiality owed to the disclosing party; or

  

	 	•	 	is independently developed by the receiving party; or 

  

	 	•	 	is approved for release in writing by an authorised representative of the disclosing party; or 

  

	 	•	 	 the receiving party is specifically required to disclose by law or pursuant to the order of any court of
competent jurisdiction provided that, in the case of a disclosure under the Freedom of Information Act, none of the exemptions in that Act applies to the information and further provided that, the receiving party shall provide advance written notice
to the disclosing party 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

  

	 	If either party receives a request under the Freedom of Information Act to disclose any information, it will notify and consult with the other party. The other party will respond within five days after receiving notice if the notice
requests assistance in determining whether or not an exemption in the Act applies. 

  

	 	4.	ASSIGNMENT 

  

	 	4.1	Neither party may assign or delegate or subcontract any of its obligations under this Agreement without the prior written consent of the other except to an affiliate or in connection with the sale or other disposition
of substantially all the assets of the assigning party’s business to which this Agreement relates. 

  

	 	5.	TERMINATION 

  

	 	5.1	This Agreement may be terminated by either party for any breach of the obligations set out in this Agreement, by giving thirty (30) days’ written notice to the other of its intention to terminate. The notice
shall include a detailed statement describing the nature of the breach. If the breach is capable of being remedied and is remedied within the thirty-day notice period, then the termination shall not take
effect. If the breach is of a nature such that it can be fully remedied but not within the thirty day notice period, then termination shall also not be effective if the party involved begins to remedy the breach within that period, and then
continues diligently to remedy the breach until it is remedied fully. If the breach is incapable of remedy, then the termination shall take effect at the end of the thirty day notice period in any event. In addition, this Agreement may be terminated
by Evelo for any reason, by giving sixty (60) days’ written notice to Weatherden of Evelo’s intention to terminate. 

  

	 	5.2	Either party shall have the right to terminate this Agreement by serving written notice to the other party in the event that a party has a petition presented for its winding up otherwise than for the purpose of a bona
fide amalgamation or reconstruction, or compounds with its creditors, or has a receiver or administrative receiver appointed of all or any part of its assets, or enters into any arrangements with creditors, or takes or suffers any similar action in
consequence of debts. 

  

	 	5.3	The termination of this Agreement under Clause 5.1 or Clause 5.2 shall mean the termination as from the effective date of termination of the obligations imposed on the parties under Clauses 1 and 2. Clause 3.1 shall
survive for seven until the termination of the Confidentiality Agreement. The remaining clauses shall survive termination indefinitely. 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

  

	 	6.	REPRESENTATIONS/INDEMNITY/LIMITATION OF LIABILITY 

  

	 	6.1	Weatherden represents and warrants that it is authorized to enter into this Agreement and will make every effort to supply the Services with reasonable care and skill and in compliance with all applicable laws and
regulations. None of the succeeding sub-clauses will operate to exclude or restrict any liability which Weatherden may have for death or personal injury resulting from negligence. Weatherden further represents
and warrants that the conduct and provision of Services will not knowingly violate any patent, trade secret or other proprietary or intellectual property right of a third party. 

 

	 	6.2	Weatherden accepts no responsibility for any use which may be made of any work carried out under or pursuant to this Agreement, nor for any reliance which may be placed on such work or results, nor for advice or
information given in connection with them, unless such arises from Weatherden’s negligence, misconduct or breach of this Agreement or any representations or warranties hereunder. 

 

	 	6.3	No condition is made or to be implied nor is any warranty given or to be implied as to the quality, life or wear of any materials supplied, or that they will be suitable for any particular purpose or for use under any
specific conditions. 

  

	 	6.4	Evelo undertakes to make no claim in connection with this Agreement or its subject matter against any employee, agent or appointee of Weatherden (apart from claims based on negligence, fraud or wilful misconduct). This
undertaking is intended to give protection to individuals: it does not prejudice any right which the Evelo might have to claim against Weatherden. 

  

	 	6.5	Except for a breach of confidentiality, the liability of either party for any breach of this Agreement, or arising in any other way out of the subject-matter of this Agreement, will not extend to loss of business or
profit, or to any indirect, punitive, or consequential damages or losses. 

  

	 	6.6	In any event, the maximum liability of either party to the other party under or otherwise in connection with this Agreement or its subject matter shall not exceed the return of all moneys provided by the Evelo under
Clause 2.1 together with interest on the balance of such moneys from time to time outstanding, accruing from day to day at the HSBC Bank UK Base Rate from time to time in force and compounded annually as at 31 December. 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

  

	 	6.7	If any sub-clause of this Clause 6 is held to be invalid or unenforceable under any applicable statute or rule of law then it shall be deemed to be omitted, and if as a result any
party becomes liable for loss or damage which would otherwise have been excluded then such liability shall be subject to the remaining sub-clauses of this clause 6. 

 

	 	6.8	Weatherden shall indemnify, defend and hold harmless Evelo, and its respective officers, directors, employees and agents (collectively, the “Evelo Indemnitees”) against any third party claims, to the
extent arising out of or relating to: (i)any Weatherden Indemnitee’s negligence or willful misconduct in performing obligations under this Agreement; or (iii) Weatherden’s breach of this Agreement. 

 

	 	6.9	Weatherden shall carry insurance sufficient to meet its obligations herein, including carrying worker’s compensation, comprehensive general liability coverage with contractual liability, and professional
liability/errors and omissions coverage. Upon request of Evelo, Weatherden will provide evidence of such coverage. 

  

	 	7.	NOTICES 

  

	 	7.1	Weatherden’s representative for the purpose of receiving payments, reports and other notices shall until further notice be: 

Houman Ashrafian, Weatherden, 93 Jack Straws Lane, Oxford, OX3 0DW United Kingdom 

XXXXXX 

Evelo’s representative for the purpose of receiving invoices shall until further notice be: 

Evelo Biosciences, Inc. 

620 Memorial Drive, Suite 200 

Cambridge, MA 02139 

finance@evelobio.com, cc: Jennifer@evelobio.com 

Evelo’s representative for the purpose of receiving reports and other notices shall until further notice be: 

Evelo Biosciences, Inc. 

620 Memorial Drive, Suite 200 

Cambridge, MA 02139 

Attn: Legal Department 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

  

	 	8.	INTELLECTUAL PROPERTY 

  

	 	8.1	Evelo shall own all rights, including all intellectual property rights, to any inventions, documents, discoveries, improvements, ideas, processes, formulations, products, programs, works of authorship, trade secrets, know-how, information, data, reports, and all other products and/or materials arising from or made in the performance of Services (whether or not patentable) (“Inventions”) in relation to the microbiome
platform. Weatherden shall disclose and hereby assigns all right, title and interest in and to all such Inventions, and shall ensure its employees and agents disclose and assign such Inventions, to Evelo. 

 

	 	9.	GENERAL 

  

	 	9.1	Clause headings are inserted in this Agreement for convenience only, and they shall not be taken into account in the interpretation of this Agreement. 

 

	 	9.2	Amounts specified for payment in this Agreement are stated exclusive of Value Added Tax. Whenever Evelo is obliged to make a payment to Weatherden under this Agreement which attracts Value Added, sales, use, excise or
other similar taxes or duties, Evelo shall be responsible for paying such taxes and duties, except taxes based on Weatherden’s income. 

  

	 	9.3	If the Evelo fails to make any undisputed payment due Weatherden under this Agreement then, without prejudice to the Weatherden’s other rights and remedies consequent upon breach of this Agreement, Weatherden may
charge interest on the balance outstanding, accruing from day to day at the rate of four per cent (4%) per annum above the HSBC Bank UK Base Rate from time to time in force and compounded annually as at 31 December. 

 

	 	9.4	If the performance by either party of any of its obligations under this Agreement shall be prevented by circumstances beyond its reasonable control, then such party shall be excused from performance of that obligation
for the duration of the relevant event and the other party may terminate the Agreement without penalty. 

  

	 	9.5	No one except a party to this Agreement has any right to prevent the amendment of this Agreement or its termination; and no one except a party may enforce any benefit conferred by this Agreement, unless this Agreement
expressly provides otherwise. 

  

	 	9.6	Nothing in this Agreement shall create, imply or evidence any partnership or joint venture between Weatherden and Evelo or the relationship between them of principal and agent. 

 

	 	9.7	Neither Weatherden nor Evelo shall use the name or any trademark or logo of the other in any press release or product advertising, or for any other commercial purpose, without the prior written consent of the other;
provided, however, that publication of the sums received from Evelo in Weatherden’s Annual Report and similar publications shall not be regarded as a breach of this clause. 

 

	 	9.8	This Agreement and its two Schedules (which are incorporated into and made a part of this Agreement) constitute the entire agreement between the parties for the supply of the Services. Any variation shall be in writing
and signed by authorised signatories for both parties. 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

  

	 	9.9	INTENTIONALLY OMITTED 

  

	 	9.10	If any one or more clauses or sub-clauses of this Agreement would result in this Agreement being prohibited pursuant to any applicable competition law then it or they shall be
deemed to be omitted. The parties shall uphold the remainder of this Agreement, and shall negotiate an amendment which, as far as legally feasible, maintains the economic balance between the parties. 

 

	 	9.11	This Agreement may be executed in any number of counterparts, each of which when executed will constitute an original of this Agreement, but all counterparts will together constitute the same agreement. No counterpart
will be effective until each Party has executed at least one counterpart. 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

 IN WITNESS of this Agreement, the Parties have executed this Agreement through their duly authorised representatives.

  

					
	SIGNED for and on behalf of Weatherden Limited	  	)	  	
		  	)	  	
		  	)	  	
		  	)	  	 /s/ Houman Ashrafian

	Name: Houman Ashrafian	  		  	
			
	Title: Executive Chairman	  		  	
			
	Date:	  		  	
			
	SIGNED for and on behalf of Evelo	  	)	  	
		  	)	  	 /s/ Simba Gill

	Name: Simba Gill	  		  	
			
	Title: Chief Executive Officer	  		  	
			
	Date:	  		  	

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

 THIS VARIATION to the agreement made on 1 January 2017 (“initial agreement”) between: 

 

	(1)	Weatherden Limited (UK registered company 09241011) whose registered office is at 93 Jack Straws Lane, Oxford, United Kingdom (“Weatherden”); and 

 

	(2)	Evelo Biosciences, Inc., a private company incorporated in Delaware USA with company offices at 620 Memorial Drive, Suite 200, Cambridge, MA 02139, United States (“Evelo”); 

Is made on 22 July 2017: 
 In line with
the initial agreement: 
 Weatherden agree to provide additional Clinical Operations support to Evelo by assigning a Weatherden consultant (Harjit Singh) to
provide further support to Evelo’s portfolio. 
 The consultant will initially be assigned to provide an additional two working days of support to
Evelo from 22nd July 2017, which will increase to 5 days of support from October 1st. The support will continue until Evelo no longer require this support. The allocated time can be reduced at any point with 1 month notice in writing. For this time
and until such time as Evelo reduce the time the consultant will be dedicated to Evelo. Should the current consultant no longer be available then a new consultant will be found and on agreement with Evelo will take over the support. 

Evelo agree to an increase in cost structure from that outlined in the initial agreement of an additional £1000 (GDP) per day of Weatherden
consultant’s time assigned to Evelo. Monthly invoices shall include actual days worked and a summary of work performed as well as breakdown of work by project. All sick or holiday time shall not be booked but indicated on the monthly invoice.

 In line with the initial agreement, all reasonable business expenses incurred by the Weatherden consultant related to delivery of the services provided
to Evelo by Weatherden will be reimbursed in addition to support costs. All business expenses over $250 will be approved in writing prior to commitment. 

			
	

	  	
		  	 WEATHERDEN
  

www.weatherden.co.uk

  

					
	SIGNED for and on behalf of Weatherden Limited	  	)	  	
		  	)	  	
		  	)	  	
		  	)	  	 /s/ Duncan McHale

	Name: Duncan McHale	  	
		
	Title: Chief Executive Officer	  	
		
	Date:	  	
	SIGNED for and on behalf of Evelo	  	)	  	
		  	)	  	 /s/ Jennifer Glennon

	Name: Jennifer Glennon	  	
		
	Title: Vice President, Finance and Operations	  	
		
	Date:

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