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                                                                     EXHIBIT 4.5

THIS OPTION AND THE WARRANTS, SHARES OF COMMON STOCK AND SHARES OF PREFERRED
STOCK ISSUABLE UPON EXERCISE OF THIS OPTION AND THE WARRANTS AND CONVERSION OF
THE PREFERRED STOCK HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED (THE "SECURITIES ACT") AND MAY NOT BE TRANSFERRED IN VIOLATION OF ANY
APPLICABLE SECURITIES LAWS. THIS OPTION IS ALSO SUBJECT TO THE RESTRICTIONS ON
TRANSFER SET FORTH IN SECTION 3 HEREOF. THIS LEGEND SHALL BE ENDORSED UPON ANY
OPTION ISSUED IN EXCHANGE FOR THIS OPTION AND, UNLESS SUCH SECURITIES HAVE BEEN
REGISTERED UNDER THE SECURITIES ACT, ON ANY WARRANTS, SHARES OF COMMON STOCK OR
SHARES OF PREFERRED STOCK ISSUABLE UPON EXERCISE OF THIS OPTION AND THE WARRANTS
OR UPON CONVERSION OF THE PREFERRED STOCK.

                     OPTION TO PURCHASE UNITS CONSISTING OF
                          WARRANTS AND PREFERRED STOCK

                                       OF

                             OMNICOMM SYSTEMS, INC.

         This is to certify that, FOR VALUE RECEIVED, Noesis Capital Corp. or
assigns ("Holder"), is entitled to purchase, subject to the provisions of this
Option, from OmniComm Systems, Inc., a Delaware corporation (the "Company"),
2.48475 Units, each Unit consisting of (a) 10,000 fully paid, validly issued and
non-assessable shares (the "Preferred Shares") of Series C Convertible Preferred
Stock of the Company ("Preferred Stock"), each share of Preferred Stock
convertible into 40 shares of common stock, par value $.01 per share (the
"Common Stock") and (b) 5-year warrants (the "Warrants") to purchase 200,000
shares of Common Stock at an exercise price of $.25 per share of Common Stock,
at an exercise price of $100,000 per Unit (the "Exercise Price"). The number of
Preferred Shares, the conversion rate of the Preferred Stock and the number of
shares of Common Stock issuable upon exercise and the exercise price of the
Warrants are subject to adjustment upon the occurrence of certain events as set
forth in Section 5 hereof.

         This Option is exercisable at any time or from time to time during the
five year period commencing on the date hereof and terminating at 5:00 p.m. New
York City time on March 31, 2008 (the "Exercise Period"). The aggregate number
shares of Common Stock issuable upon exercise of the Warrants and conversion of
the Preferred Stock deliverable upon exercise of this Option, as adjusted from
time to time, are hereinafter sometimes referred to as "Underlying Shares." This
Option was originally issued pursuant to an Agency Agreement (the "Agency
Agreement") dated March 29, 2002 between the Company and Noesis Capital Corp.
("Noesis"), for nominal consideration.

         The shares of Preferred Stock issuable upon exercise of this Option are
to be authorized and issued pursuant to the provisions of a Certificate of
Designations, Preferences and Rights of Series B Convertible Preferred Stock
(the "Certificate of Designation") filed with the Secretary of State of the
State of Delaware on March 27, 2002. The Warrants issuable upon exercise of this
Option are to be authorized and issued pursuant to that certain Warrant
Agreement, dated March 29, 2002, between the Company and Noesis (the "Warrant
Agreement").

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         (1) EXERCISE OF OPTION.

                  (a) The rights represented by this Option may be exercised at
any time during the Exercise Period, in whole or in part, by (i) the surrender
of this Option (with the purchase form at the end hereof properly executed) at
the principal executive office of the Company (or such other office or agency of
the Company as it may designate by notice in writing to the Holder at the
address of the Holder appearing on the books of the Company); and (ii) payment
to the Company of the exercise price then in effect for the number of Units
specified in the above-mentioned purchase form together with applicable stock
transfer taxes, if any. This Option shall be deemed to have been exercised, in
whole or in part to the extent specified, immediately prior to the close of
business on the date this Option is surrendered and payment is made in
accordance with the foregoing provisions of this Section 1, and the person or
persons in whose name or names the certificates for the Preferred Shares and
Warrants shall be issuable upon such exercise shall become the holder or holders
of record of such Preferred Shares and Warrants at that time and date. The
certificates for the Preferred Shares and Warrants so purchased shall be
delivered to the Holder as soon as practicable but not later than seven (7) days
after the rights represented by this Option shall have been so exercised. If
this Option should be exercised in part only, the Company shall, upon surrender
of this Option for cancellation, execute and deliver a new Option evidencing the
rights of the Holder thereof to purchase the balance of the Units purchasable
thereunder.

                  (b) At any time during the Exercise Period, the Holder may, at
its option, exchange this Option, in whole or in part (an "Option Exchange"),
into the number of Units determined in accordance with this Section (b), by
surrendering this Option at the principal office of the Company or at the office
of its stock transfer agent, if any, accompanied by a notice stating such
Holder's intent to effect such exchange, the number of Units subject to the
Option Exchange and the date on which the Holder requests that such Option
Exchange occur (the "Notice of Exchange"). The Option Exchange shall take place
on the date specified in the Notice of Exchange or, if later, the date the
Notice of Exchange is received by the Company (the "Exchange Date").
Certificates for the Preferred Shares and Warrants issuable upon such Option
Exchange and, if applicable, a new Option of like tenor evidencing the balance
of the Units remaining subject to this Option, shall be issued as of the

Exchange Date and delivered to the Holder within seven (7) days following the
Exchange Date. In connection with any Option Exchange, this Option shall
represent the right to subscribe for and acquire the number of Units (rounded to
the next highest integer) equal to (x) the number of Units specified by the
Holder in its Notice of Exchange up to the maximum number of Units subject to
this Option (the "Total Number") less (y) the number of Units equal to the
quotient obtained by dividing (A) the product of the Total Number and the
existing Exercise Price by (B) the Fair Market Value of a Unit. "Fair Market
Value of a Unit" shall by the sum of the current market value of the Underlying
Shares represented by such Unit (as adjusted in accordance with Section 5
hereof) less the exercise price associated with the exercise of the Warrants
which are part of such Unit. The current market value of the Underlying Shares
of Common Stock shall be determined as follows:

                  (i) If the Common Stock is listed on a national securities
                  exchange or admitted to unlisted trading privileges on such
                  exchange or listed for trading on the Nasdaq National Market
                  System ("NMS"), the current market value shall be the average
                  of the last reported sale price on such exchange or system for
                  the 10 trading days prior to the Exchange Date; provided that
                  if no sale is made on a day within such period or no closing
                  sale price is quoted, that day's market value shall be the
                  average of the closing bid and asked prices for such day on
                  such exchange or system; or

                  (ii) If the Common Stock is not so listed or admitted to
                  unlisted trading privileges, but is traded on the Nasdaq
                  SmallCap Market, the current market value shall be the average
                  of the closing bid and asked prices for the 10 trading days
                  prior to the Exchange Date on such market and if the Common
                  Stock is not so traded, the current market value shall be the
                  mean of the last reported bid and asked prices reported by the
                  NASD Electronic Bulletin Board for the 10 trading days prior
                  to the Exchange Date; or

                  (iii) If the Common Stock is not so listed or admitted to
                  unlisted trading privileges and bid and asked prices are not
                  so reported, the current market value shall be an amount
                  determined in a reasonable manner by the Board of Directors of
                  the Company.

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         (2) RESERVATION OF SHARES. The Company shall at all times reserve for
issuance and/or delivery upon exercise of this Option such number of shares of
its Preferred Stock and the number of shares of Common Stock as shall be
required for issuance and delivery upon exercise of this Option in full and the
exercise in full of the Warrants and conversion of all the shares of Preferred
Stock issuable upon exercise of this Option.

         (3) EXCHANGE, TRANSFER, ASSIGNMENT OR LOSS OF OPTION. This Option is
exchangeable, without expense, at the option of the Holder, upon presentation
and surrender hereof to the Company or at the office of its stock transfer
agent, if any, for other Options of different denominations entitling the holder
thereof to purchase in the aggregate the same number of shares of Preferred
Stock and Warrants purchasable hereunder. This Option may be assigned or
transferred only to a direct or indirect affiliate of Noesis or an employee of
or consultant to Noesis (a "Permitted Transferee"). Upon surrender of this
Option to the Company at its principal office or at the office of its stock
transfer agent, if any, with the Assignment Form annexed hereto duly executed
and funds sufficient to pay any transfer tax, the Company shall, without charge,
execute and deliver a new Option in the name of the Permitted Transferee named
in such instrument of assignment and this Option shall promptly be canceled.
This Option may be divided or combined with other Options which carry the same
rights upon presentation hereof at the principal office of the Company or at the
office of its stock transfer agent, if any, together with a written notice
specifying the names and denominations in which new Options are to be issued and
signed by the Holder hereof. The term "Option" as used herein includes any
Options into which this Option may be divided or exchanged. Upon receipt by the
Company of evidence satisfactory to it of the loss, theft, destruction or
mutilation of this Option, and (in the case of loss, theft or destruction) of
reasonably satisfactory indemnification, and upon surrender and cancellation of
this Option, if mutilated, the Company will execute and deliver a new Option of
like tenor and date. Any such new Option executed and delivered shall constitute
an additional contractual obligation on the part of the Company, whether or not
this Option so lost, stolen, destroyed, or mutilated shall be at any time
enforceable by anyone.

         (4) RIGHTS OF THE HOLDER. The Holder shall not, by virtue hereof, be
entitled to any rights of a shareholder in the Company, either at law or equity,
and the rights of the Holder are limited to those expressed in the Option and
are not enforceable against the Company except to the extent set forth herein.

         (5) ANTI-DILUTION PROVISIONS.

                  (a) Upon exercise of this Option, the terms of the shares of
Preferred Stock and Warrants issuable hereunder shall be adjusted to give effect
to any anti-dilution adjustments which would have been made pursuant to Section
7 of the Certificate of Designation or Section 8 of the Warrant Agreement, as
the case may be, if such shares of Preferred Stock and Warrants had been issued
on the date hereof it being the intent of the parties that the shares of
Preferred Stock and Warrants issuable upon exercise of this Option shall be
convertible into or exercisable for the number of shares of Common Stock or such
other securities, and at an exercise price, as the holder hereof would have
received had this Option been exercised and the Preferred Stock and Warrants
been issued on the date hereof.
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                  (b) In case the Company shall hereafter (i) declare a dividend
or make a distribution on its outstanding shares of Preferred Stock in shares of
Preferred Stock, (ii) subdivide or reclassify its outstanding shares of
Preferred Stock into a greater number of shares, (iii) combine or reclassify its
outstanding shares of Preferred Stock into a smaller number of shares, (iv)
effect any other reclassification, capital reorganization or change of
outstanding shares of Preferred Stock, (v) consolidate or merge the Company with
or into another corporation (other than a merger with a subsidiary in which
merger the Company is the continuing corporation and which does not result in
any reclassification, capital reorganization or other change of outstanding
shares of Preferred Stock) or (vi) sell, lease or convey to another corporation
all or substantially all of the property of the Company (collectively, a
"Transaction"), the Company shall, as a condition precedent to such transaction,
cause effective provisions to be made so that upon exercise of this Option the
Holder shall receive the kind and amount of securities and property which would
have been received by such Holder had this Option been exercised, and, if
applicable, the Preferred Stock converted and the Warrants exercised,
immediately prior to such Transaction and the Holder received the benefits
conferred on the holders of such securities and property as a result of such
Transaction. Any such provision shall include provision for adjustments which
shall be as nearly equivalent as may be practicable to the adjustments provided
for in this Option.

                  (c) If any event or condition occurs as to which other
provisions of this Section 5 are not strictly applicable or if strictly
applicable would not fairly protect the exercise or purchase rights of Options
and the Preferred Stock and Warrants issuable hereunder in accordance with the
essential intent and principles of such provisions, or which might materially
and adversely affect the exercise or purchase rights of the Holder hereunder,
then the Company shall make an adjustment in the application of such provisions,
or if necessary the applicable provisions of the Preferred Stock and Warrants,
so as to preserve without dilution the rights of the Holder. In no event shall
any adjustment under this paragraph 5 have the effect of increasing the Exercise
Price of this Option.

         (6) NOTICES.

                  (a) Whenever this Option shall be adjusted as required by the
provisions of the foregoing Section, the Company shall forthwith file in the
custody of its Secretary or an Assistant Secretary at its principal office and
with its stock transfer agent, if any, an officer's certificate showing the
adjustments determined as herein provided, setting forth in reasonable detail
the facts requiring such adjustment and the manner of computing such adjustment.
Each such officer's certificate shall be made available at all reasonable times
for inspection by the Holder and the Company shall, forthwith after each such
adjustment, mail a copy by certified mail of such certificate to the Holder or
any such holder.

                  (b) So long as this Option shall be outstanding, (i) if the
Company shall pay any dividend or make any distribution upon the Preferred Stock
or Common Stock or (ii) if the Company shall offer to the holders of Preferred
Stock or Common Stock for subscription or purchase by them any share of any
class or any other rights, (iii) if any capital reorganization of the Company,
reclassification of the capital stock of the Company, consolidation or merger of
the Company with or into another corporation, sale, lease or transfer of all or

                                      -4-
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substantially all of the property and assets of the Company to another
corporation, or voluntary or involuntary dissolution, liquidation or winding up
of the Company shall be effected, or (iv) if the Company is required to notify
the holders of Preferred Stock pursuant to the terms of the Certificate of
Designation or the holders of warrants pursuant to the terms of the Warrant
Agreement or for any reason determines to notify the holders of Preferred Stock
or such warrants, then in any such case, the Company shall cause to be mailed by
certified mail to the Holder, in the case of (i), (ii) or (iii) above, at least
fifteen days prior the date specified in (x) or (y) below, as the case may be, a
notice containing a brief description of the proposed action and stating the
date on which (x) a record is to be taken for the purpose of such dividend,
distribution or rights, or (y) such reclassification, reorganization,
consolidation, merger, conveyance, lease, dissolution, liquidation or winding up
is to take place and the date, if any is to be fixed, as of which the holders of
Preferred Stock or other securities shall receive cash or other property
deliverable upon such reclassification, reorganization, consolidation, merger,
conveyance, dissolution, liquidation or winding up or in the case of (iv) on the
date such notice is sent to the holders of Preferred Stock or warrants.

         (7) REGISTRATION UNDER THE SECURITIES ACT OF 1933. The Company agrees
to register the Underlying Shares for resale under the Securities Act of 1933,
as amended (the "Act") on the terms and subject to the conditions set forth in
Annex A to the Subscription Agreement between the Company and each of the
investors in the offering contemplated by the Agency Agreement, it being the
intent of the parties that the holder of this Option shall have all the rights
of a holder of Securities under Annex A to the Subscription Agreement and that
the Underlying Shares shall be treated as "Conversion Shares" and "Warrant
Shares" under Annex A to the Subscription Agreement.

         (8) GOVERNING LAW. This Option shall be governed by and in accordance
with the laws of the State of Florida, without giving effect to the principles
of conflicts of law thereof.

                                                     OMNICOMM SYSTEMS, INC.

                                                     By:
Dated                                                   -----------------------
      --------------                                    Name:
                                                        Title:

                                      -5-
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                                  PURCHASE FORM

                                                          Dated ________________

         The undersigned hereby irrevocably elects to exercise the within Option
to the extent of purchasing __________ Units and hereby

         [ ]  makes payment of $_______ in payment of the actual exercise
              price thereof

          or

         [ ]  elects to effect an Option Exchange in accordance with
              Section 1(b) on _______ [DATE].

                     INSTRUCTIONS FOR REGISTRATION OF UNITS

Name
     -----------------------------------------
(Please typewrite or print in block letters)

Address
         -------------------------------------

Signature
         -------------------------------------

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                                 ASSIGNMENT FORM

    FOR VALUE RECEIVED, _____________ hereby sells, assigns and transfers unto

Name
     -----------------------------------------
(Please typewrite or print in block letters)

Address
         -------------------------------------

the right to purchase Preferred Stock and Warrants represented by this Option to
the extent of _____Units as to which such right is exercisable and does hereby
irrevocably constitute and appoint ______ as Attorney, to transfer the same on
the books of the Company with full power of substitution in the premises.

Date
      ---------------------------------

Signature
      ---------------------------------<PAGE>
                                                                    EXHIBIT 10.8

                        AMENDMENT TO EMPLOYMENT AGREEMENT

         THIS AMENDMENT TO EMPLOYMENT AGREEMENT dated as of August 22, 2003 by
and between Omnicomm Systems, Inc. (the "Company"), a Delaware corporation, and
Cornelis Wit (the "Executive").

         1. Reference is hereby made to that certain Employment Agreement (the
"Employment Agreement") dated June 1, 2002 by and between the Company and
Executive. All terms used herein and not otherwise defined herein shall have the
same meaning as set forth in the Employment Agreement.

         2. Paragraph 2 of the Employment Agreement shall be amended in its
entirety to read as follows:

                  "Term and Termination. This Agreement shall commence on June
                  1, 2002 and shall terminate as of the earlier of:

                  (a)      December 31, 2004, unless extended by the Company;

                  (b)      the death or disability of the Executive. Disability
                           shall mean the Executive's inability, due to sickness
                           or injury, to perform effectively his duties
                           hereunder for a period of at least 90 consecutive
                           days;

                  (c)      thirty (30) days after notice is given by the Company
                           to the Executive after a material breach hereof by
                           the Executive; or,

                  (d)      thirty (30) days after notice is given by the
                           Executive to the Company after a material breach
                           hereof by the Company.

         The exercise of the Company's or the Executive's right to terminate
this Agreement pursuant to clause (c) or (d) hereof, as the case may be, shall
not abrogate the rights and remedies of the terminating party in respect of the
breach giving rise to such termination.

         3. Except as otherwise amended hereby the terms and conditions of the
Employment Agreement shall remain in full force and effect.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the day and year first hereinabove written.

OMNICOMM SYSTEMS, INC.

BY: /s/ RANDALL SMITH
   -------------------------------
    Name: Randall Smith
    Title: Chairman of the Board

EXECUTIVE:

/s/ CORNELIS WIT
--------------------
Cornelis Wit

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