Document:

Exhibit 10.25

SEVENTH AMENDMENT

to

LEASE BETWEEN

EMERY STATION OFFICE II, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

EMERYSTATION NORTH PROJECT

Emeryville, California

 

That certain Lease dated May 5, 2002 by and between Emery Station
Office II, LLC (successor-in-interest to Emery Station Associates II, LLC), as Landlord, and KineMed, Inc., as Tenant, (the “Original
Lease”) as such was amended via First Amendment executed on June 27, 2003 (the “First Amendment”), via Second
Amendment whose effective date was December 1, 2004 (the “Second Amendment”), via Revised Third Amendment whose effective
date was February 28, 2005 (the “Third Amendment”), via Revised Fourth Amendment whose effective date was March 15,
2005 (the “Fourth Amendment”), via Fifth Amendment whose effective date was August 31, 2008 (the “Fifth Amendment”),
and via Sixth Amendment whose effective date was December 1, 2008 (the “Sixth Amendment”), is hereby further amended
as follows (the Original Lease as amended previously by the First, Second, Third, Fourth, Fifth and Sixth Amendments, and now by
this Seventh Amendment, are collectively referred to as the “Lease”). The effective date of this Seventh Amendment
shall be May 1, 2009 (the “Seventh Amendment Effective Date”).

 

		1.	Effective June 1, 2009, the Premises shall be expanded to include that 2,559 rentable square foot suite more specifically defined
on Exhibit A-1 hereof (the “Seventh Amendment Lab Space”). Tenant shall have the right to commence it's move-in to
the Seventh Amendment Lab Space as early as May 25, 2009, such Tenant occupancy prior to June 1, 2009 being pursuant to all the
terms of the Lease other than the obligation to pay Rent on the Seventh Amendment Lab Space. Tenant shall accept the Seventh Amendment
Lab Space in its existing as-is condition. After inclusion of the Seventh Amendment Lab space, Tenant's Premises shall total 15,454
rentable square feet.

 

		2.	The Lease shall be extended such that its Expiry Date shall be May 31, 2012.

 

		3.	Monthly Base Rent for the Premises shall be as follows:
	 	 	 

		·	Prior to June 1, 2009: per the terms of the Lease prior to this Seventh Amendment.

		·	For the period of June 1 - 31, 2009: $37,008.64

		·	           

		·	For July 1, 2009 - June 30, 2010: $44,352.98 monthly

Commencing June 30, 2010 and annually thereafter,
Monthly Base Rent shall be increased by three percent (3%) annually. In addition to the Monthly Base Rent outlined above, Tenant
shall remain obligated to pay all Rent Adjustment Deposits and Rent Adjustments called for by the Lease. Tenant shall also remain
obligated to pay the agreed amortization of Base Rent Deferrals referenced in prior Lease amendments until said Base Rent Deferrals
are paid in full.

 

    	 

    	 

    

 

		4.	Subject to the rights of other tenants pursuant to leases in effect as of the Date of Lease, Tenant shall have a one-time right
of first offer to lease the “Vivarium Space” on the fourth (4th) floor of the Building as it becomes available (the
“Right of First Opportunity”). As used in this Section 4, “Vivarium Space” shall mean that
existing 1,938 rentable square foot vivarium formerly occupied by Tenant and more specifically outlined in Exhibit A-2 hereof.
Upon the earlier to occur of a) Landlord proposes to enter into a letter of intent or some other form of agreed set of primary
lease terms for a lease lasting longer than six (6) months with a prospective tenant for lease of the Vivarium Space, orb) December
31, 2009, Landlord shall give written notice thereof to Tenant (the “ROFO Offer Notice”).Tenant shall have a
period of five (5) business days after receipt of Landlord's ROFO Offer Notice to determine and notify Landlord formally, in writing,
that its elects to lease the Vivarium Space on the following terms:

*on
an “as-is” basis,

*for
a term expiring at the same time as the balance of Tenant's space (namely March 31, 2013),

*at
the same Monthly Base Rental Rate, calculated on a per rentable square foot basis, as is applicable to Tenant's base Lease, and 

*requiring
Tenant's Security Deposit to be increased by $5,562.06

 

Tenant's written notice to Landlord of its election
to lease the Vivarium Space shall be referred to as “Tenant's Vivarium Space Acceptance Notice”. Failure by Tenant
to send Landlord Tenant's Vivarium Space Acceptance Notice shall be deemed Tenant's election not to lease said space, in which
case Landlord shall be free to enter into a lease thereof with any other party on any other terms Landlord shall elect in its sole
and absolute discretion.

 

 

Notwithstanding anything to the contrary contained
herein, all rights of Tenant pursuant to this Section 4 with respect to the Vivarium Space shall, at Landlord's election upon notice
to Tenant, be of no further force or effect with respect to the Vivarium Space, whether or not Tenant has timely exercised the
Right of First Offer granted herein with respect thereto, and Landlord shall have no obligation to deliver any ROFO Offer Notice
to Tenant with respect to the Vivarium Space, if a Default exists at the time of exercise of the Right of First Offer, or at the
time that Landlord would otherwise be required to deliver such ROFO Offer Notice, or at the time of commencement of the term of
the lease for the Vivarium Space.

 

If Tenant sends Landlord Tenant's Vivarium Space
Acceptance Notice, pursuant to this Section 4, Landlord promptly shall prepare such a lease amendment setting forth the agreed
terms and conditions for the Vivarium Space and Tenant shall promptly execute same and return it to Landlord..

 

    	 

    	 

    

 

		5.	Simultaneously with the mutual execution hereof, the Security Deposit shall be increased by $7,344.33. Tenant shall remit this
amount to Landlord together with its signed copy of the Seventh Amendment.

 

		6.	Tenant hereby represents to Landlord that Jonathan Tomasco of Cornish & Carey has been its broker representative in this
transaction and that, other than to him, no brokerage commission will be payable to any tenant broker or representative as a result
hereof.

 

		7.	Except for those terms outlined herein, all other terms and conditions of the Lease and Work Letter
shall apply.

 

In witness hereof, the parties have executed this Seventh Amendment
as of the date noted below.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation	 	Emery Station Office II LLC, a 
	 	 	California Limited Liability Company
	 	 	 	 
	By:	/s/ David M. Fineman	 	By:	/s/ Richard K Robbins
	 	 	 	 	 
	Print Name: 	David M. Fineman	 	Print Name: 	 
	 	 	 	 	 
	Its: 	President	 	Its: 	 
	 	 	 	 	 
	Dated: 5/1/09	 	Dated: 5/09/09Exhibit 10.26

EIGHTH AMENDMENT

to

LEASE BETWEEN

EMERY STATION OFFICE II, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

That certain Lease dated May 5, 2002 by and between Emery Station
Office II, LLC (successor-in-interest to Emery Station Associates II, LLC), as Landlord, and KineMed, Inc., as Tenant, (the “Original
Lease”) as such was amended via First Amendment executed on June 27, 2003 (the “First Amendment”), via Second
Amendment whose effective date was December 1, 2004 (the “Second Amendment”), via Revised Third Amendment whose effective
date was February 28, 2005 (the “Third Amendment”), via Revised Fourth Amendment whose effective date was March 15,
2005 (the “Fourth Amendment”), via Fifth Amendment whose effective date was August 3 I , 2008 (the “Fifth Amendment”),
whose Sixth Amendment with a contemplated effective date of December 1, 2008 (the “Sixth Amendment”) was never fully
executed by mutual agreement of the parties, and via Seventh Amendment whose effective date was May 1, 2009 (the “Seventh
Amendment”), is hereby further amended as follows (the Original Lease as amended previously by the First, Second, Third,
Fourth, Fifth and Seventh Amendments, and now by this Eighth Amendment, are collectively referred to as the “Lease”).
The effective date of this Eighth Amendment shall be July 31, 2010 (the “Eighth Amendment Effective Date”).

 

		I.	Notwithstanding the terms of the Lease otherwise, Landlord hereby agrees to waive Tenant's Monthly
Base Rent as well as Tenant's Rent Adjustments and Rent Adjustment Deposits for the months of August and of September of 2010 (the
“Rent Forgiveness”). During those two months Tenant will continue to pay currently, as required by the Lease, its separately-measured
and billed in-Premises electrical usage. Commencing October 1, 2010, Monthly Base Rent, Rent Adjustments, Rent Adjustment Deposits
and all other amounts will be due and payable as called for in the existing Lease terms.

 

		II.	Landlord and Tenant hereby agree to extend the expiry of the Lease Term by two (2) months to become
July 31, 2012.

 

		III.	Tenant's Right of First Opportunity on the 1,938 rentable square foot Vivarium Space outlined in
Section 4 of the Seventh Amendment is hereby made null and void.

 

		IV.	Landlord and Tenant hereby agree that Landlord shall have the right, at its sole and absolute discretion,
to require Tenant to relocate Tenant's animal holding and procedure room functions presently contained in the 1,367 rentable square
foot portion of Tenant's Premises more fully described on Exhibit A-1 hereof (the “Existing Vivarium Space”), to that
portion of the EmeryStation East Building, located at 5885 Hollis Street more specifically defined in Exhibit B-1 hereof (the “New
Vivarium Space”). The EmeryStation East Building is owned by E S East, LLC, an affiliate of Landlord. Landlord's right shall
be referred to as Landlord's “Vivarium Relocation Right” and said relocation by Tenant shall be referred to as the
“ESE Relocation”. Landlord can invoke its Vivarium Relocation Right at any time via formal written notice to Tenant
and Tenant agrees to complete the ESE Relocation within sixty days of Landlord's notice. Landlord's Vivarium Relocation Right and
the ESE Relocation shall be pursuant to all the terms and conditions listed below:

 

    	 

    	 

    

 

		a)	In the event Landlord elects, in its sole and absolute discretion, to notice Tenant of Landlord's
election to use its Vivarium Relocation Right, Landlord and Tenant agree to promptly meet and confer to mutually determine the
timing and other specifics of Tenant's ESE Relocation, each using commercially-reasonable considerations, but Tenant hereby acknowledges
and agrees that, should Landlord so require, in no event shall the ESE Relocation occur later than December 31, 2010. Upon completion
of the ESE Relocation, Tenant shall be prohibited from operating an animal holding facility/vivarium in the EmeryStation North
Building for the duration of its Lease Term, as such may be extended.

 

		b)	Tenant hereby agrees and acknowledges that the New Vivarium Space is sufficient for its needs and
agrees to accept the New Vivarium Space in its existing as-is condition subject only to the contemplated alterations outlined in
more detail herein. As soon as practicable following the Eighth Amendment Effective Date but in no event later than reasonably
required to allow the ESE Relocation to be completed by no later than December 31, 2010, Landlord and Tenant shall cooperate to
create a mutually-approved plan for improvements to the New Vivarium Space necessary to make it reasonably similar to the improvements
to the Existing Vivarium Space, acknowledging the fact that its location in a building separate from the balance of Tenant's Premises
is not as convenient as if it were in the same building adjacent to and part of Tenant's Premises. Landlord and Tenant agree that
the New Vivarium TI shall consist generally of the items referred to in Exhibit B-2 hereof. The improvements mentioned above shall
be referred to as the “New Vivarium TI” and the drawings and specifications outlining the New Vivarium TI shall be
referred to as the “New Vivarium TI Drawings”. The New Vivarium TI Drawings and the New Vivarium TI shall be completed
at the sole cost and expense of Landlord. Upon completion of the New Vivarium TI Drawings, Landlord will determine the rentable
area of the New Vivarium Space using BOMA standards (the “New Vivarium Space Rentable Area”).

 

    	 

    	 

    

 

		c)	As soon as practicable following the Effective Date hereof, Tenant agrees to enter into a new lease
with landlord E S East, LLC governing Tenant's occupancy of the New Vivarium Space (the “New Vivarium Lease”). The
New Vivarium Lease will contain all relevant terms outlined in this Eighth Amendment applicable to the New Vivarium Space, including
stating E S East, LLC as Landlord and the New Vivarium Space Rentable Area as the rentable area of the leased premises under said
New Vivarium Lease. Notwithstanding that the New Vivarium Space Rentable Area may differ from the rentable area of the Existing
Vivarium Space, The Monthly Base Rent Tenant shall pay E S East, LLC under the New Vivarium Lease for the New Vivarium Space shall
be calculated based on the rentable square footage of the Existing Vivarium Space, not that of the New Vivarium Space, and calculated
using the Monthly Base Rental Rates applicable to Tenant's Lease at EmeryStation North, as those are more fully described in the
Seventh Amendment. The New Vivarium Lease shall specify that Tenant shall pay its pro-rata share of Operating Expenses and Taxes
using the pro-rata share applicable to the Existing Vivarium in the EmeryStation North Building (as opposed to that pro-rata share
that represents the ratio of the New Vivarium Rentable Area to the rentable area (of the EmeryStation East building. Notwithstanding
the above, the first six (6) months of New Vivarium Lease term shall be free of Monthly Base Rent (but not of expenses; those shall
be paid currently each month). Other than those terms specifically outlined herein, the New Vivarium Lease will be pursuant to
all the terms and conditions of the Lease.

 

		d)	Landlord shall reimburse Tenant for the reasonable third-party moving costs associated with the
ESE Relocation.

 

		e)	Any failure by Tenant to perform any of the duties and responsibilities outlined above shall constitute
a Default under the Lease.
	 	 	 

		V.	On or before thirty (30) days following the completion of Tenant's ESE Relocation, Landlord shall
have the right, at its sole and absolute discretion, to elect one of the following options regarding the Existing Vivarium Space
(“Landlord's Existing Vivarium Option 1 and Option 2”):

 

Landlord's Existing Vivarium Option 1 

Landlord shall have the right,
upon written notice to Tenant, to terminate Tenant's Lease as it applies to the 1,367 rentable square foot Existing Vivarium Space,
such termination to be effective no later than thirty (30) days following Landlord's notice. Following such termination, Tenant's
Premises will measure 14,087 rentable square feet and from that da forward Tenant's Monthly Base Rent, Rent Adjustment Deposits
and Rent Adjustments will be reduced pro-rata to reflect the revised, smaller Premises. Landlord understands that the Existing
Vivarium space includes an area used by Tenant for developing film (the “Darkroom Area”). lf, upon Landlord's notice
to Tenant of its election of Vivarium Option 1, Tenant promptly thereafter notices Landlord of its continued need for reasonably-similar
darkroom space, Landlord agrees to work cooperatively with Tenant to satisfy such need, either by continuing to rent to Tenant
a portion of the Existing Vivarium space or some alternative, mutually-acceptable space, either of said solutions to be at the
rental rates and other terms specified in the Lease.

 

    	 

    	 

    

 

Landlord's Existing Vivarium Option 2 

Landlord shall have the right ,
upon written notice to Tenant, to cause Tenant's Premises to continue to include the Existing Vivarium Space, subject to the prohibitions
regarding animals outlined in Section IV(a) above, and to require Tenant to pay Rent therefore in accordance with the existing
Lease terms, however for the first three (3) months after Landlord's notice to Tenant of its election of Option 2 the Existing
Vivarium Space will be free of Monthly Base Rent and for the subsequent three (3) months Tenant shall only be liable to pay fifty
percent (50%) of the Monthly Base Rent otherwise applicable to the Existing Vivarium Space.

 

		VI.	Tenant hereby represents to Landlord that it has represented itself in this transaction and that
no brokerage commission will be payable to any tenant broker or representative as a result hereof.

 

		VII.	Except for those terms outlined herein, all other terms and conditions of the Lease, as amended,
and Work Letter shall apply.

 

In witness hereof, the parties have executed this Eighth Amendment.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation	 	Emery Station Office II LLC, a 
	 	 	California Limited Liability Company
	 	 	 	 
	By:	/s/ David M. Fineman	 	By:	/s/ Richard K. Robbins
	 	 	 	 	 
	Print Name: 	David M. Fineman	 	Print Name: 	 
	 	 	 	 	 
	Its:	President & CEO	 	Its: 	 
	 	 	 	 	 
	Dated: 7/30/10	 	Dated: 8/2/10

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