Document:

Exhibit 10.2

  

  

  

   FORWARD PURCHASE AGREEMENT 

   

    

  This Forward Purchase Agreement (this “Agreement”) is entered into as of
    July 4, 2022, by and among Health Sciences Acquisitions Corporation 2, a Cayman Islands exempted company (which shall deregister in the Cayman Islands and domesticate as a Delaware corporation prior to the Merger Closing, “Parent”), Orchestra BioMed, Inc., a Delaware corporation (the “Company”), and the purchasing parties
    signatory hereto (the “Purchasing Parties”). Capitalized terms used but not defined in this Agreement shall have the meanings ascribed to such terms in that
    certain Agreement and Plan of Merger, dated as of the date of this Agreement, by and among Parent, the Company and HSAC Olympus Merger Sub, Inc. (the “Merger Agreement”).

  

  

  WHEREAS, in connection with the Closing under the Merger Agreement (the “Merger
        Closing”), the Purchasing Party wishes to purchase, up to 1,000,000 Parent Ordinary Shares on the terms and conditions set forth herein; and

  

  

  NOW, THEREFORE, in consideration of the premises, representations, warranties and the mutual covenants contained in this Agreement, and for other good and
    valuable consideration, the receipt, sufficiency and adequacy of which are hereby acknowledged, the parties hereto agree as follows:

  

  

  1.          Forward Purchase Shares. Parent shall issue and sell to the Purchasing Party, and the Purchasing Party shall
      purchase from Parent, a number of Parent Ordinary Shares (the “Forward Purchase Shares”) equal to (a) (i) $10,000,000 minus (ii) the aggregate dollar amount paid by the Purchasing Party to purchase Parent Ordinary Shares having redemption rights following the date hereof until immediately prior to the
      Share Purchase Closing that the Purchasing Party continues to directly own at such time (the “Market Transaction Shares”), divided by (b) $10.00 (the “Per Share Price”). For the avoidance of doubt, in no event shall the aggregate amount of funds received by Parent in respect of the Forward Purchase Shares, when taken
    together with funds that continue to be held in the Trust Account at the Merger Closing in respect of the Market Transaction Shares, be less than $10,000,000.

   

    

  2.          Share Purchase
      Closing. 

  

  

  (a)          Closing. Subject to Section 7, the closing of the sale of the Forward Purchase Shares, if any (the
      “Share Purchase Closing”), shall be held on the Closing Date, immediately prior to the Domestication. At the Share Purchase Closing, Parent will issue to the
      Purchasing Party the Forward Shares against (and concurrently with) the payment to Parent by the Purchasing Party of an amount equal to the product of (i) the number of Forward Purchase Shares, multiplied by (ii) the Per Share Price. All payments
      required to be made to Parent by the Purchasing Party pursuant to this Section 2(a) shall be made by wire transfer of immediately available funds pursuant to
      written instructions provided by Parent to the Purchasing Party.

  

  

  
    (b)          Delivery of Forward Purchase Shares.

  

  

  

  (i)          Parent shall register the Purchasing
      Party as the owner of the Forward Purchase Shares on Parent’s share register and with Parent’s transfer agent by book entry on or promptly after (but in no event more than two (2) Business Days after) the date of the Share Purchase Closing.

  

  

  (ii)          Each register and book entry for the
      Forward Purchase Shares shall contain a notation, and each certificate (if any) evidencing the Forward Purchase Shares shall be stamped or otherwise imprinted with a legend, in substantially the following form:

  

  

  “THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE
    OR OTHER JURISDICTION, AND MAY NOT BE TRANSFERRED IN VIOLATION OF SUCH ACT AND LAWS. 

  

  

  (c)          In connection with sales permitted pursuant to Rule 144 promulgated under the Exchange Act, if required by Parent’s transfer agent, Parent will promptly cause an opinion of counsel to be delivered to its transfer agent,
    together with any other authorizations, certificates and directions required by the transfer agent that authorize and direct the transfer agent to transfer such Forward Purchase Shares without any such legend.

  
    
      

  

  (d)          Registration Rights. The Purchasing Party shall have registration rights with respect to their Forward Purchase Shares as set forth in the Registration Rights Agreement that will be entered into by and among
      Parent, the Purchasing Party, the Company and certain other parties thereto in connection with the consummation of the transactions contemplated by the Merger Agreement (the “Transactions”)

      and the form of which is attached to the Merger Agreement as Exhibit C (the “Registration Rights Agreement”).

  

  

  (e)          Adjustments to Notional Amounts. In the event of any change to the capital structure of Parent, whether dilutive or otherwise, by way of a share dividend, share split, or any other similar transaction however
      described, the number of Forward Purchase Shares, and/or the Per Share Price, as applicable, will be adjusted as necessary to account for such changes.

  

  

  3.          Representations and Warranties of the Purchasing Party. The Purchasing Party represents and warrants, severally and not jointly, to each of Parent and the Company as follows:

  

  

  (a)          Organization and Power. The Purchasing Party is duly organized, validly existing, and in good standing under the Laws of the jurisdiction of its formation and has all requisite power and authority to carry on
      its business as presently conducted and as proposed to be conducted.

  

  

  (b)          Authorization. The Purchasing Party has full power and authority to enter into this Agreement. This Agreement, when executed and delivered by the Purchasing Party, will constitute the valid and legally binding
      obligation of Purchasing Party, enforceable in accordance with its terms, except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance and any other Laws of general application affecting enforcement of
      creditors’ rights generally, (ii) as limited by Laws relating to the availability of specific performance, injunctive relief or other equitable remedies, or (iii) to the extent the indemnification provisions contained in the Registration Rights
      Agreement may be limited by applicable federal or state securities Laws.

  

  

  (c)          Governmental Consents and Filings. No consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with, any federal, state or local governmental authority
      is required on the part of the Purchasing Party in connection with the consummation of the transactions contemplated by this Agreement.

  

  

  (d)          Compliance with Other Instruments. The execution, delivery and performance by the Purchasing Party of this Agreement and the consummation by the Purchasing Party of the transactions contemplated by this
      Agreement will not result in any violation or default (i) of any provisions of its organizational documents, (ii) of any instrument, judgment, order, writ or decree to which it is a party or by which it is bound, (iii) under any note, indenture or
      mortgage to which it is a party or by which it is bound, (iv) under any lease, agreement, contract or purchase order to which it is a party or by which it is bound or (v) of any provision of federal or state statute, rule or regulation applicable to
      the Purchasing Party, in each case (other than clause (i)), which would have a material adverse effect on the Purchasing Party or its ability to consummate the transactions contemplated by this Agreement. 

  

  

  (e)          Purchase Entirely for Own Account. This Agreement is made with the Purchasing Party in reliance upon the Purchasing Party’s representation to Parent, which by the Purchasing Party’s execution of this
      Agreement, the Purchasing Party hereby confirms, that the Forward Purchase Shares to be acquired by the Purchasing Party will be acquired for investment for the Purchasing Party’s own account, not as a nominee or agent, and not with a view to the
      resale or distribution of any part thereof, and that the Purchasing Party has no present intention of selling, granting any participation in, or otherwise distributing the same in violation of Law. By executing this Agreement, the Purchasing Party
      further represents that the Purchasing Party does not presently have any contract, undertaking, agreement or arrangement with any Person to sell, transfer or grant participations to such Person or to any third Person, with respect to any of the
      Forward Purchase Shares.

  
    
      

  

  (f)          Disclosure of Information. The Purchasing Party has had an opportunity to discuss Parent’s existing and planned or expected business, management, financial affairs and the terms and conditions of the purchase
      and sale of the Forward Purchase Shares, as well as the terms of the Transactions, with Parent’s management.

  

  

  (g)          Restricted Forward Purchase Shares. The Purchasing Party understands that the offer and sale of the Forward Purchase Shares to the
      Purchasing Party has not been, and will not be, registered under the Securities Act, by reason of a specific exemption from the registration provisions of the Securities Act which depends upon, among other things, the bona fide nature of the
      investment intent and the accuracy of the Purchasing Party’s representations as expressed herein. The Purchasing Party understands that the Forward Purchase Shares are “restricted securities” under applicable U.S. federal and state securities Laws
      and that, pursuant to these Laws, the Purchasing Party must hold the Forward Purchase Shares indefinitely unless they are registered with the SEC and qualified by state authorities, or an exemption from such registration and qualification
      requirements is available. The Purchasing Party acknowledges that Parent has no obligation to register or qualify the Forward Purchase Shares, or any securities into which the Forward Purchase Shares may be converted into or exercised for, for
    resale, except pursuant to the Registration Rights Agreement. The Purchasing Party further acknowledges that if an exemption from registration or qualification is available, it may be conditioned on various requirements including, but not limited to,
    the time and manner of sale, the holding period for the Forward Purchase Shares, and on requirements relating to Parent which are outside of the Purchasing Party’s control, and which Parent is under no obligation and may not be able to satisfy.

  

  

  (h)          High Degree of Risk. The Purchasing Party understands that its agreement to purchase the Forward Purchase Shares involves a high degree of risk, which could cause the Purchasing Party to lose all or part of
      its investment.

  

  

  (i)          Accredited Investor. The Purchasing Party is an “accredited investor” as defined in Rule 501(a) of Regulation D promulgated under the Securities Act.

  

  

  (j)          No General Solicitation. Neither the Purchasing Party, nor any of its officers, directors, employees, agents, stockholders or partners has
      either directly or indirectly, including, through a broker or finder (i) to its knowledge, engaged in any general solicitation, or (ii) published any advertisement in connection with the purchase and sale of the Forward Purchase Shares.

  

  

  (k)          Non-Public Information. The Purchasing Party acknowledges its obligations under applicable securities Laws with respect to the treatment of material non-public information relating to Parent.

  

  

  (l)          Adequacy of Financing. The Purchasing Party will have at the Share Purchase Closing available to it sufficient funds to satisfy its obligations under this Agreement.

  

  

  (m)          Affiliation of Certain FINRA Members. The Purchasing Party is neither a person associated nor affiliated with any underwriter of the IPO or, to its actual knowledge, any other member of the Financial Industry
      Regulatory Authority (“FINRA”) that participated in the IPO.

  

  

  (n)          No Finder’s Fees. The Purchasing Party is not and will not be obligated for any finder’s fee or commission in connection with the transactions contemplated by this Agreement.

  

  

  (o)          Foreign Corrupt Practices. Neither the Purchasing Party, nor any director, officer, agent, employee or other Person acting on behalf of the Purchasing Party has, in the course of its actions for, or on behalf
      of, the Purchasing Party (i) used any corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to political activity; (ii) made any direct or indirect unlawful payment to any foreign or domestic
      government official or employee from corporate funds; (iii) violated or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended; or (iv) made any unlawful bribe, rebate, payoff, influence payment, kickback or
      other unlawful payment to any foreign or domestic government official or employee.

  
    
      

  

  (p)          Compliance with Anti-Money Laundering Laws. The operations of the Purchasing Party are and have been conducted at all times in compliance with applicable financial recordkeeping and reporting requirements and
      all other applicable U.S. and non-U.S. anti-money laundering Laws and regulations, including, but not limited to, those of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the USA PATRIOT Act of 2001 and the applicable money
      laundering statutes of all applicable jurisdictions, the rules and regulations thereunder and any related or similar rules, regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the “Anti-Money Laundering Laws”), and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the
      Purchasing Party with respect to the Anti-Money Laundering Laws is pending or, to the knowledge of the Purchasing Party, threatened.

  

  

  (q)          No Other Representations and Warranties; Non-Reliance. Except for the specific representations and warranties contained in this Section

          3 and in any certificate or agreement delivered pursuant hereto, none of the Purchasing Party nor any person acting on behalf of the Purchasing Party nor any of the Purchasing Party’s affiliates (“Purchasing Party Group”) has made, makes or shall be deemed to make any other express or implied representation or warranty with respect to the Purchasing Party or the purchase and sale of
      the Forward Purchase Shares, and the Purchasing Party disclaim any such representation or warranty. Except for the specific representations and warranties expressly made by (i) Parent in Section 4 of this Agreement and in any certificate or agreement delivered pursuant hereto and (ii) the Company in Section 5 of this Agreement, the Purchasing Party Group specifically disclaims that it is relying
      upon any other representations or warranties that may have been made by Parent, any person on behalf of Parent or any of Parent’s affiliates (collectively, the “Parent
          Parties”).

  

  

  4.          Representations and Warranties of Parent. Parent represents and warrants to
      the Purchasing Party as follows:

  

  

  (a)          Incorporation and Corporate Power. Parent is an exempted company duly incorporated, validly existing and in good standing under the Laws of the Cayman Islands and has all requisite corporate power and
      authority to carry on its business as presently conducted and as proposed to be conducted.

  

  

  (b)          Capitalization. The authorized share capital of Parent consists, as of the date hereof, of 100,000,000 shares of Parent Ordinary Shares and 1,000,000 preference shares, of which 20,450,000 Parent Ordinary
      Shares and no Parent Preferred Shares are issued and outstanding. All of the issued and outstanding Parent Ordinary Shares and preference shares have been duly authorized, are fully paid and nonassessable and were issued in compliance with all
      applicable federal and state securities Laws.

  

  

  (c)          Authorization. All corporate action required to be taken by Parent’s Board of Directors and shareholders in order to authorize Parent to enter into this Agreement, and to issue the Forward Purchase Shares at
      the Share Purchase Closing has been taken or will be taken prior to the Share Purchase Closing, as applicable. All action on the part of the shareholders, directors and officers of Parent necessary for the execution and delivery of this Agreement,
      the performance of all obligations of Parent under this Agreement to be performed as of the Share Purchase Closing, and the issuance and delivery of the Forward Purchase Shares has been taken or will be taken prior to the Share Purchase Closing. This
      Agreement, when executed and delivered by Parent, shall constitute a valid and legally binding obligation of Parent, enforceable against Parent in accordance with its terms except (i) as limited by applicable bankruptcy, insolvency, reorganization,
      moratorium, fraudulent conveyance, or other Laws of general application relating to or affecting the enforcement of creditors’ rights generally, (ii) as limited by Laws relating to the availability of specific performance, injunctive relief, or other
      equitable remedies, or (iii) to the extent the indemnification provisions contained in the Registration Rights Agreement may be limited by applicable federal or state securities Laws.

  

  

  
    (d)          Valid Issuance of Forward Purchase Shares.

  

  

  

  (i)          The Forward Purchase Shares, when issued, sold and delivered in accordance with the terms and for the consideration set forth in this Agreement and registered in the register of members of the Company when issued in accordance
      with this Agreement, and registered on Parent’s share register, will be validly issued, fully paid and nonassessable and free of all preemptive or similar rights, liens, encumbrances and charges with respect to the issue thereof and restrictions on
      transfer other than restrictions on transfer specified under this Agreement, applicable state and federal securities Laws and liens or encumbrances created by or imposed by the Purchasing Party, as applicable. Assuming the accuracy of the
    representations of the Purchasing Party in this Agreement and subject to the filings described in Section 4(e) below, the Forward Purchase Shares will be issued
    in compliance with all applicable federal and state securities Laws.

  
    
      

  

  (ii)          No “bad actor” disqualifying event described in
      Rule 506(d)(1)(i)-(viii) of the Securities Act (a “Disqualification Event”) is applicable to Parent or, to Parent’s knowledge, any Parent Covered Person (as
      defined below), except for a Disqualification Event as to which Rule 506(d)(2)(ii—iv) or (d)(3), is applicable. “Parent Covered Person” means, with respect to
      Parent as an “issuer” for purposes of Rule 506 promulgated under the Securities Act, any Person listed in the first paragraph of Rule 506(d)(1).

  

  

  (e)          Governmental Consents and Filings. Assuming the accuracy of the representations and warranties made by the Purchasing Party in this Agreement, no consent, approval, order or authorization of, or registration,
      qualification, designation, declaration or filing with, any federal, state or local governmental authority is required on the part of Parent in connection with the consummation of the transactions contemplated by this Agreement, except for filings
      pursuant to Regulation D of the Securities Act, applicable state securities Laws and pursuant to the Registration Rights Agreement.

  

  

  (f)          Compliance with Other Instruments. The execution, delivery and performance of this Agreement and the consummation of the transactions
      contemplated by this Agreement will not result in any violation or default (i) of any provisions of Parent’s Governing Documents, as they may be amended from time to time, (ii) of any instrument, judgment, order, writ or decree to which Parent is a
      party or by which it is bound, (iii) under any note, indenture or mortgage to which Parent is a party or by which it is bound, (iv) under any lease, agreement, contract or purchase order to which Parent is a party or by which it is bound or
    (v) of any provision of federal or state statute, rule or regulation applicable to Parent, in each case (other than clause (i)) which would have a material adverse effect on Parent or its ability to consummate the transactions contemplated by this
    Agreement.

  

  

  (g)          Operations. As of the date hereof, Parent has not conducted any operations other than organizational activities and activities in connection with the IPO, its search for a potential business combination and
      financing in connection therewith.

  

  

  (h)          Foreign Corrupt Practices. Neither Parent, nor any director, officer, agent, employee or other Person acting on behalf of Parent has, in the course of its actions for, or on behalf of, Parent (i) used any
      corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to political activity; (ii) made any direct or indirect unlawful payment to any foreign or domestic government official or employee from corporate
      funds; (iii) violated or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended; or (iv) made any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic
      government official or employee.

  

  

  (i)          Compliance with Anti-Money Laundering Laws. The operations of Parent are and have been conducted at all times in compliance with applicable financial recordkeeping and reporting requirements and all other
      applicable U.S. and non-U.S. anti-money laundering Laws and regulations, including, but not limited to, Anti-Money Laundering Laws, and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator
      involving Parent with respect to the Anti-Money Laundering Laws is pending or, to the knowledge of Parent, threatened.

  

  

  (j)          Absence of Litigation. There is no Action before or by any Governmental Authority or, to the Knowledge of Parent, threatened against or affecting Parent or any of Parent’s officers or directors, whether of a
      civil or criminal nature or otherwise, in their capacities as such.

  

  

  (k)          No General Solicitation. Neither Parent, nor any of its officers, directors, employees, agents or shareholders has either directly or indirectly, including, through a broker or finder (i) engaged in any
      general solicitation, or (ii) published any advertisement in connection with the offer and sale of the Forward Purchase Shares.

  
    
      

  

  (l)          No Other Representations and Warranties; Non-Reliance. Except for the specific representations and warranties contained in this Section

          4 and in any certificate or agreement delivered pursuant hereto, none of Parent Parties has made, makes or shall be deemed to make any other express or implied representation or warranty with respect to Parent, the transactions
      contemplated by the Merger Agreement or the offer and sale of the Forward Purchase Shares, and the Parent Parties disclaim any such representation or warranty. Except for the specific representations and warranties expressly made by the Purchasing
      Party in Section 3 of this Agreement and in any certificate or agreement delivered pursuant hereto, the Parent Parties specifically disclaim that they are
      relying upon any other representations or warranties that may have been made by the Purchasing Party.

  

  

  
    5.          Representations and Warranties of the Company.

  

  

  

  (a)          Merger Agreement. The Company (i) represents and warrants to the Purchasing Party that, the representations and warranties of the Company in the Merger Agreement are true and correct as of the date hereof and
      will be true and correct as of the Closing Date (other than any such representation or warranty that is made by its terms as of a specified date, which shall be true and correct as of such specified date), in each case, other than as would not
      individually or in the aggregate reasonably be expected to have a Material Adverse Effect in respect of the Company and its Subsidiaries and (ii) acknowledges and agrees that the Purchasing Party is relying on the accuracy of such representations and
      warranties as set forth in the preceding clause (i).

  

  

  (b)          No Other Representations and Warranties; Non-Reliance. Except for the specific representations and warranties contained in this Section 5 and in any certificate or agreement delivered pursuant hereto, neither
      the Company nor any person acting on behalf of the Company nor any of the Company’s affiliates (the “Company Group”) has made, makes or shall be deemed to make
      any other express or implied representation or warranty with respect to the Company, the transactions contemplated by the Merger Agreement or the offer and sale of the Forward Purchase Shares, and the Company Group disclaims any such representation
      or warranty. Except for the specific representations and warranties expressly made by the Purchasing Party in Section 3 of this Agreement and in any certificate or agreement delivered pursuant hereto, the Company specifically disclaims that it is
      relying upon any other representations or warranties that may have been made by the Purchasing Party

  

  

  
    6.          Additional Agreements, Acknowledgements and Waivers of the Purchasing Party.

  

  

  

  (a)          Waiver. Reference is made to the final prospectus of Parent, dated August 3, 2020 (the “Prospectus”). The Purchasing
      Party has read the Prospectus and understands that Parent has established the Trust Account for the benefit of the public Parent Shareholders and the underwriters of the IPO pursuant to the Trust Agreement and that, except for a portion of the
      interest earned on the amounts held in the Trust Account, Parent may disburse monies from the Trust Account only for the purposes set forth in the Trust Agreement. For and in consideration of Parent agreeing to enter into this Agreement, the Company
      and the Purchasing Party for itself and on behalf of its securityholders, hereby agrees that it does not now and shall not at any time hereafter have any right, title, interest or claim of any kind in or to any monies in the Trust Account as a result
      of, or arising out of, any negotiations, contracts or agreements with Parent and hereby agrees that it will not seek recourse against the Trust Account for any reason.

  

  

  (b)          No Short Sales. The Purchasing Party hereby agrees that neither it, nor any person or entity acting on its behalf or pursuant to any understanding with it, will engage in any Short Sales with respect to
      securities of Parent prior to the Merger Closing. For purposes of this Section 6, “Short

          Sales” shall include, without limitation, all “short sales” as defined in Rule 200 promulgated under Regulation SHO under the Exchange Act and all types of direct and indirect stock pledges (other than pledges in the ordinary course of
      business as part of prime brokerage arrangements), forward sale contracts, options, puts, calls, swaps and similar arrangements (including on a total return basis), and sales and other transactions through non-U.S. broker dealers or foreign regulated
      brokers.

  

  

  (c)          No Redemption. Until the Merger Closing, the Purchasing Party hereby irrevocably and unconditionally agrees not to redeem, elect to redeem or tender or submit any Subject Securities in connection with (i)

    the Merger or any other transactions contemplated by the Merger Agreement or (ii) any proposal to amend Parent’s organizational documents to extend the period of time that Parent is afforded thereunder and its prospectus to consummate an initial
    business combination, including any vote at any meeting of the shareholders of Parent (whether annual or special and whether or not an adjourned or postponed meeting however called and including any adjournment or postponement thereof) or any action by
    written resolution of the shareholders of Parent with respect to the foregoing, and any attempt to redeem such Subject Securities will be void ab initio and

    of no effect. For purposes of this Agreement, “Subject Securities” means all of Purchasing Party’s Parent Ordinary Shares and any other equity securities of Parent
    that the Purchasing Party holds of record or beneficially as of the date of this Agreement or acquires record or beneficial ownership after the date hereof, including any (i) Market Transaction Shares and (ii) Parent Warrants or other securities
    convertible into or exercisable or exchangeable for Parent Ordinary Shares.
    
      
        

    

  

  
    7.          Share Purchase Closing Conditions.

  

  

  

  (a)          The obligation of each of the Purchasing Party to
      consummate the Share Purchase Closing is subject to the fulfillment, at or prior to the Share Purchase Closing of each of the following conditions, any of which, to the extent permitted by applicable Laws, may be waived by the Purchasing Party (or,
      with respect to clauses (ii) and (iii), the Company on its behalf), as applicable:

  

  

  (i)          The conditions set forth in Article X of the
      Merger Agreement (other than those conditions that by their nature are to be satisfied by (i) actions taken at the Merger Closing; provided that each such condition is then capable of being satisfied at the Merger Closing on such date and (ii) the
      consummation of the transactions contemplated by this Agreement) have been satisfied or waived (provided that, for purposes of this Agreement, the conditions set forth in Sections 10.3(h) and 10.3(j) in the Merger Agreement may not be waived without
      the written consent of the Purchasing Party), and the Company and Parent have confirmed to the Purchasing Party in writing that the Company and Parent are ready, willing and able to consummate the Transactions;

  

  

  (ii)          The representations and warranties of Parent set
      forth in Section 4 shall have been true and correct as of the date hereof and shall be true and correct as of the Share Purchase Closing, as applicable, with
      the same effect as though such representations and warranties had been made on and as of such date (other than any such representation or warranty that is made by its terms as of a specified date, which shall be true and correct as of such specified
      date), except where the failure to be so true and correct would not have a material adverse effect on Parent’s ability to consummate the transactions contemplated by this Agreement;

  

  

  (iii)          Parent shall have performed, satisfied and
      complied in all material respects with the covenants, agreements and conditions required by this Agreement to be performed, satisfied or complied with by Parent, at or prior to the Share Purchase Closing; and

  

  

  (iv)          No order, writ, judgment, injunction, decree,
      determination, or award shall have been entered by or with any governmental, regulatory, or administrative authority or any court, tribunal, or judicial, or arbitral body, and no other legal restraint or prohibition shall be in effect, preventing the
      purchase by the Purchasing Party of the Forward Purchase Shares.

  

  

  (v)          Since the date of the Merger Agreement, there
      shall not have occurred any Material Adverse Effect pursuant to clause (a) of the definition thereof in the Merger Agreement in respect of the Company Group that is continuing.

  

  

  (b)          The obligation of Parent to consummate the Share
      Purchase Closing is subject to the fulfillment, at or prior to the Share Purchase Closing of each of the following conditions, any of which, to the extent permitted by applicable Laws, may be waived by Parent (or, with respect to clauses (ii) and
      (iii), the Company on their behalf):

  

  

  (i)          The conditions set forth in Article X of the
      Merger Agreement (other than those conditions that by their nature are to be satisfied by actions taken at the Merger Closing; provided that each such condition is then capable of being satisfied at the Merger Closing on such date) to Parent’s
      obligations to consummate the Merger Closing have been satisfied or waived, and the Company has confirmed to Parent in writing that the Company is ready, willing and able to consummate the Transactions;

  
    
      

  

  (ii)          The representations and warranties of the
      Purchasing Party set forth in Section 3 shall have been true and correct as of the date hereof and shall be true and correct as of the Share Purchase Closing,
      as applicable, with the same effect as though such representations and warranties had been made on and as of such date (other than any such representation or warranty that is made by its terms as of a specified date, which shall be true and correct
      as of such specified date), except where the failure to be so true and correct would not have a material adverse effect on the Purchasing Party or its ability to consummate the transactions contemplated by this Agreement;

  

  

  (iii)          The Purchasing Party shall have performed,
      satisfied and complied in all material respects with the covenants, agreements and conditions required by this Agreement to be performed, satisfied or complied with by the Purchasing Party at or prior to the Share Purchase Closing; and

  

  

  (iv)          No order, writ, judgment, injunction, decree,
      determination, or award shall have been entered by or with any governmental, regulatory, or administrative authority or any court, tribunal, or judicial, or arbitral body, and no other legal restraint or prohibition shall be in effect, preventing the
      purchase by the Purchasing Party of the Forward Purchase Shares.

  

  

  (v)          Parent shall have received evidence reasonably
      satisfactory of (i) the Purchasing Party’s ownership of the Market Transaction Shares and purchase thereof following the date hereof and (ii) the aggregate dollar amount paid by the Purchasing Party to purchase the Market Transaction Shares.

  

  

  
    8.          Termination. This Agreement
        may be terminated at any time prior to the Share Purchase Closing:

  

   
  

  

  	

        	(a)	
          by mutual written consent of the parties hereto; or

        

  

  

  	

        	(b)	
          automatically upon the termination of the Merger Agreement in accordance with its terms.

        

  

  

  In the event of any termination of this Agreement pursuant to this Section 8,
    this Agreement shall forthwith become null and void and have no effect, without any liability on the part of any party hereto and their respective directors, officers, employees, partners, managers, members, or shareholders and all rights and
    obligations of each party shall cease; provided, however, that nothing
    contained in this Section 8 shall relieve either Parent or the Purchasing Party from liabilities or damages arising out of any fraud or willful breach by such
    party of any of its representations, warranties, covenants or agreements contained in this Agreement.

  

  

  
    9.          General Provisions.

  

  

  

  (a)          Survival of Representations. Subject to the limitations and other provisions of this Agreement, the representations and warranties contained herein shall survive the Share Purchase Closing and shall remain in
      full force and effect until the first anniversary of the Closing Date.

  
    
      

  

  (b)          Notices. Any notice hereunder shall be sent in writing, addressed as specified below, and shall be deemed given: (i) if by hand, electronic mail or nationally recognized overnight courier service, by 5:00 PM
      Pacific Time on a Business Day, addressee’s day and time, on the date of delivery, and if delivered after 5:00 PM Eastern Time, on the first Business Day after such delivery; (ii) if by email, on the date of transmission with affirmative confirmation
      of receipt; or (iii) three (3) Business Days after mailing by prepaid certified or registered mail, return receipt requested. Notices shall be addressed to the respective parties as follows (excluding telephone numbers, which are for convenience
      only), or to such other address as a party shall specify to the others in accordance with these notice provisions:

  

  

  If to Parent, to:

  

  

  Health Sciences Acquisitions Corporation 2 

  c/o RTW Investments, LP

  40 10th Avenue, Floor 7

   New York, New York 10014 

  Attn: Legal Department

  E-mail: al@hsac2.com, gd@hsac2.com

  

  

  with a copy to Parent’s counsel (which shall not
      constitute notice) to: 

   

  

  Loeb & Loeb LLP

  345 Park Ave

  New York, NY 10154 

  Attention: Giovanni Caruso

   E-mail: gcaruso@loeb.com

  All communications sent to the Company shall be sent to:

  

  

  If to the Company, to:

  

  

  Orchestra BioMed, Inc. 

  150 Union Square Drive

   New Hope PA 18938

  Attn; David Hochman, Chairman & CEO

  E-mail: DHochman@orchestrabiomed.com

  

  

  with a copy to the Company’s counsel (which shall not constitute notice) to:

  

  

  Paul Hastings LLP 

  200 Park Avenue

  New York, New York 10166

   Attn: Samuel A. Waxman

  E-mail: samuelwaxman@paulhastings.com

  

  

  All communications to the Purchasing Party shall be sent to the Purchasing Party’s address as set forth on the signature page hereof, or to such e-mail address, facsimile number
    (if any) or address as subsequently modified by written notice given in accordance with this Section 9(b).

  

  

  
    (c)          Amendments; No Waivers; Remedies.

  

  

  

  (i)          This Agreement cannot be amended, except by a
      writing signed by each party, and cannot be terminated orally or by course of conduct. No provision hereof can be waived, except by a writing signed by the party against whom such waiver is to be enforced, and any such waiver shall apply only in the
      particular instance in which such waiver shall have been given.

  

  

  (ii)          Neither any failure or delay in exercising any
      right or remedy hereunder or in requiring satisfaction of any condition herein nor any course of dealing shall constitute a waiver of or prevent any party from enforcing any right or remedy or from requiring satisfaction of any condition. No notice
      to or demand on a party waives or otherwise affects any obligation of that party or impairs any right of the party giving such notice or making such demand, including any right to take any action without notice or demand not otherwise required by
      this Agreement. No exercise of any right or remedy with respect to a breach of this Agreement shall preclude exercise of any other right or remedy, as appropriate to make the aggrieved party whole with respect to such breach, or subsequent exercise
      of any right or remedy with respect to any other breach.

  

  

  (iii)          Except as otherwise expressly provided herein, no
      statement herein of any right or remedy shall impair any other right or remedy stated herein or that otherwise may be available.

  
    
      

  

  (d)          No Assignment or Delegation. No party may assign any right or delegate any obligation hereunder, including by merger, consolidation, operation of law or otherwise, without the written consent of the other
      parties to this Agreement. Any purported assignment or delegation without such consent shall be void, in addition to constituting a material breach of this Agreement.

  

  

  (e)          Governing Law. This Agreement and all disputes or controversies arising out of or relating to this Agreement or the transactions contemplated hereby, including the applicable statute of limitations, shall be
      governed by and construed in accordance with the Laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdiction) that would cause the
      application of the Law of any jurisdiction other than the State of New York.

  

  

  (f)          Counterparts; Facsimile Signatures. This Agreement may be executed in counterparts, each of which shall constitute an original, but all of which shall constitute one agreement. This Agreement shall become
      effective upon delivery to each party of an executed counterpart or the earlier delivery to each party of original, photocopied, or electronically transmitted signature pages that together (but need not individually) bear the signatures of all other
      parties.

  

  

  (g)          Entire Agreement. This Agreement, together with the agreements referenced herein, sets forth the entire agreement of the parties with respect to the subject matter hereof and thereof and supersedes all prior
      and contemporaneous understandings and agreements related thereto (whether written or oral), all of which are merged herein. No provision of this Agreement may be explained or qualified by any agreement, negotiations, understanding, discussion,
      conduct or course of conduct or by any trade usage. Except as otherwise expressly stated herein, there is no condition precedent to the effectiveness of any provision hereof or thereof.

  

  

  (h)          Severability. A determination by a court or other legal authority that any provision that is not of the essence of this Agreement is legally invalid shall not affect the validity or enforceability of any other
      provision hereof. The parties shall cooperate in good faith to substitute (or cause such court or other legal authority to substitute) for any provision so held to be invalid a valid provision, as alike in substance to such invalid provision as is
      lawful.

  

  

  (i)          Construction. The parties hereto have participated jointly in the negotiation and drafting of this Agreement. If an ambiguity or question of intent or interpretation arises, this Agreement will be construed as
      if drafted jointly by the parties hereto and no presumption or burden of proof will arise favoring or disfavoring any party hereto because of the authorship of any provision of this Agreement. Any reference to any federal, state, local or foreign Law
      will be deemed also to refer to Law as amended and all rules and regulations promulgated thereunder, unless the context requires otherwise. The words “include,”

      “includes” and “including” will be deemed to
      be followed by “without limitation.” Pronouns in masculine, feminine, and neuter genders will be construed to include any other gender, and words in
      the singular form will be construed to include the plural and vice versa, unless the context otherwise requires. The words “this Agreement,” “herein,” “hereof,” “hereby,” “hereunder” and words of similar import refer to this Agreement
      as a whole and not to any particular subdivision unless expressly so limited. The parties hereto intend that each representation, warranty and covenant contained herein will have independent significance. If any party hereto has breached any
      representation, warranty or covenant contained herein in any respect, the fact that there exists another representation, warranty or covenant relating to the same subject matter (regardless of the relative levels of specificity) which such party
      hereto has not breached will not detract from or mitigate the fact that such party hereto is in breach of the first representation, warranty or covenant.

  
    
      

  

  (j)          Remedies. Except as otherwise expressly provided herein, any and all remedies provided herein will be deemed cumulative with and not exclusive of any other remedy conferred hereby, or by law or equity upon a
      party hereto, and the exercise by a party of any one remedy will not preclude the exercise of any other remedy. The parties agree that irreparable damage for which monetary damages, even if available, would not be an adequate remedy would occur in
      the event that the parties do not perform their respective obligations under the provisions of this Agreement (including failing to take such actions as are required of them hereunder to consummate the transactions contemplated by this Agreement) in
      accordance with their specific terms or otherwise breach such provisions. It is accordingly agreed that the parties shall be entitled to an injunction or injunctions, specific performance and other equitable relief to prevent breaches of this
      Agreement and to enforce specifically the terms and provisions of this Agreement, in each case, without posting a bond or undertaking and without proof of damages and this being in addition to any other remedy to which they are entitled at law or in
      equity. Each of the parties agrees that it will not oppose the granting of an injunction, specific performance and other equitable relief when expressly available pursuant to the terms of this Agreement on the basis that the other parties have an
      adequate remedy at law or an award of specific performance is not an appropriate remedy for any reason at law or equity.

  

  

  [Signature Page Follows]

  
    
      

  

  

  

  IN WITNESS WHEREOF, the undersigned have executed this
    Agreement to be effective as of the date first set forth above.

   

  

  
    	 	
            PURCHASING PARTY:

            RTW MASTER FUND, LTD.

          
	 
	 	 	 	 
	 	
            By:

          	
            /s/ Roderick Wong, M.D.

          
	 	 	
            Name:

          	
            Roderick Wong, M.D.

          
	 	 	
            Title:

          	
            Director

          
	 	 	 	 
	 	
            RTW INNOVATION MASTER FUND, LTD.

          
	 	 	 	 
	 	
            By:

          	
            /s/ Roderick Wong, M.D.

          
	 	 	
            Name:

          	
            Roderick Wong, M.D.

          
	 	 	
            Title:

          	
            Director

          
	 	 	 	 
	 	
            RTW VENTURE FUND LIMITED

          
	 	
            By: RTW Investments, LP, its Investment Manager

          
	 	 	 	 
	 	
            By:

          	
            /s/ Roderick Wong, M.D.

          
	 	 	
            Name:

          	
            Roderick Wong, M.D.

          
	 	 	
            Title:

          	
            Managing Partner

          
	 	 	 	 
	 	
            Address for Notices: 40 10th Avenue, Floor 7 

            New York, NY 10014

             legalops@rtwfunds.com

          
	 	 	 	 
	 	
            PARENT:

          
	 	
            Health Sciences Acquisitions Corporation 2

          
	 	 	 	 
	 	
            By:

          	
            /s/ Roderick Wong, M.D.

          
	 	 	
            Name:

          	
            Roderick Wong, M.D.

          
	 	 	
            Title:

          	
            President and Chief Executive Officer

          

    
      
        

    

    	 	 	 	 
	 	
            COMPANY

          
	 	
            Orchestra BioMed, Inc.

          
	 	 	 	 
	 	
            By:

          	
            /s/ David Hochman

          
	 	 	
            Name:

          	
            David Hochman

          
	 	 	
            Title:

          	
            Chief Executive Officer

          

     

    

    
      [Signature Page to Forward Purchase
          Agreement]Exhibit 10.3 

     

        

    Confidential

     

    BACKSTOP AGREEMENT

     

    This Backstop Agreement (this “Agreement”) is entered into as of July 4, 2022, by and among Health
        Sciences Acquisitions Corporation 2, a Cayman Islands exempted company (which shall deregister in the Cayman Islands and domesticate as a Delaware corporation prior to the Merger Closing, “Parent”), Orchestra BioMed, Inc., a Delaware
        corporation (the “Company”), and the purchasing parties signatory hereto (the “Purchasing Parties”). Capitalized terms used but not defined in this Agreement shall have the meanings ascribed to such terms in that certain Agreement and
        Plan of Merger, dated as of the date of this Agreement, by and among Parent, the Company and HSAC Olympus Merger Sub, Inc. (the “Merger Agreement”).

     

    WHEREAS, in connection with the entry into the Merger Agreement, the Purchasing Parties have agreed to
        purchase up to 5,000,000 shares of Parent Ordinary Shares at a price of $10.00 per share to the extent that the number of shares of Parent Ordinary Shares that are redeemed in connection with the consummation of the transactions contemplated by the
        Merger Agreement (the “Transactions”) would result in the Parent receiving less than the Closing Cash Amount (as defined below), on the terms and conditions set forth herein (the “Backstop Commitment”).

     

    NOW, THEREFORE, in consideration of the premises, representations, warranties and the mutual covenants
        contained in this Agreement, and for other good and valuable consideration, the receipt, sufficiency and adequacy of which are hereby acknowledged, the parties hereto agree as follows:

     

    1.           Backstop Shares.

     

    (a)         Backstop Subscription. Subject to, and contingent upon, the amount of Parent Closing Cash
        as of immediately prior to the Merger Closing (the “Closing Cash Amount”) being less than that necessary to satisfy the Minimum Available Cash Condition (such deficit, the “Backstop Subscription Amount”), Parent shall issue and sell
        to the Purchasing Parties, and the Purchasing Parties shall purchase from Parent, a number of Parent Ordinary Shares equal to the quotient of (i) the Backstop Subscription Amount, divided by (ii) $10.00 (the “Per Share Price”), rounded down
        to the nearest whole number (the “Backstop Shares”).

     

    (b)         Funding Notice. As soon as reasonably practicable following completion of the Parent
        Shareholder Redemption, Parent shall deliver a written notice (the “Funding Notice”) to the Purchasing Parties (with a copy sent concurrently to the Company) setting forth:

     

    (i)       the Parent Redemption Amount;

     

    (ii)       the Closing Cash Amount;

     

    (iii)       the Backstop Subscription Amount;

     

    (iv)       the number of Backstop Shares; and

     

    (v)       the anticipated Closing Date.

     

    Notwithstanding the foregoing, for the avoidance of doubt, the “Backstop Subscription Amount” shall be
        finally calculated without including any Parent Ordinary Shares subject to the Parent Shareholder Redemption that have been offered for redemption but subsequently and validly withdrawn by the applicable holder in accordance with the Parent’s
        amended and restated memorandum and articles of association, the Cayman Islands Companies Act or other applicable law. The delivery of the Funding Notice hereunder shall serve as notice to the Sponsor that it will be required to pay the Backstop
        Subscription Amount and acquire the Backstop Shares, if any, pursuant to Section 1(a).

     

    
       

      
        
 

    

     

    2.           Share Purchase Closing.

     

    (a)         Closing. Subject to Section 7, the closing of the sale of the Backstop Shares, if
        any (the “Share Purchase Closing”), shall be held on the Closing Date, immediately prior to the Domestication. At the Share Purchase Closing, Parent will issue to the Purchasing Parties, collectively, the Backstop Shares against (and
        concurrently with) the payment of the Backstop Subscription Amount to Parent. Such issuance will be made in the amounts to each Purchasing Party set forth in written instructions provided by the Purchasing Parties to Parent (with a copy sent
        concurrently to the Company). All payments required to be made to Parent by the Purchasing Parties pursuant to this Section 2(a) shall be made by wire transfer of immediately available funds pursuant to written instructions provided by
        Parent to the Purchasing Parties (with a copy sent concurrently to the Company). For the avoidance of doubt, the payment obligations of the Purchasing Parties under this Section 2(a) are joint and several..

     

    (b)         Delivery of Backstop Shares.

     

    (i)       Parent shall register each Purchasing Party as the owner of the Backstop Shares it was issued
        pursuant to Section 2(a) on Parent’s share register and with Parent’s transfer agent by book entry on or promptly after (but in no event more than two (2) Business Days after) the date of the Share Purchase Closing.

     

    (ii)       Each register and book entry for any Backstop Shares shall contain a notation, and each
        certificate (if any) evidencing such Backstop Shares shall be stamped or otherwise imprinted with a legend, in substantially the following form:

     

    “THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED, OR THE
        SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION, AND MAY NOT BE TRANSFERRED IN VIOLATION OF SUCH ACT AND LAWS.”

     

    (c)       In connection with sales permitted pursuant to Rule 144 promulgated under the Exchange Act, if
        required by Parent’s transfer agent, Parent will, if required, promptly cause an opinion of counsel to be delivered to its transfer agent, together with any other authorizations, certificates and directions required by the transfer agent that
        authorize and direct the transfer agent to transfer such Backstop Shares without any such legend.

     

    (d)       Registration Rights. The Purchasing Parties shall have registration rights with respect to
        their respective Backstop Shares as set forth in the Registration Rights Agreement that will be entered into by and among Parent, the Purchasing Parties, the Company and certain other parties thereto in connection with the consummation of the
        Transactions and the form of which is attached to the Merger Agreement as Exhibit E (the “Registration Rights Agreement”).

     

    (e)       Adjustments to Notional Amounts. In the event of any change to the capital structure of
        Parent, whether dilutive or otherwise, by way of a share dividend, share split, or any other similar transaction however described, the Per Share Price will be adjusted as necessary to account for such changes.

     

    3.           Representations and Warranties of the Purchasing Parties. Each Purchasing Party
        represents and warrants, jointly and severally, to each of Parent and the Company as follows:

     

    (a)       Organization and Power. Such Purchasing Party is duly organized, validly existing, and in
        good standing under the Laws of the jurisdiction of its formation and has all requisite power and authority to carry on its business as presently conducted and as proposed to be conducted.

     

    (b)       Authorization. Such Purchasing Party has full power and authority to enter into this
        Agreement. This Agreement, when executed and delivered by such Purchasing Party, will constitute the valid and legally binding obligation of such Purchasing Party, enforceable in accordance with its terms, except (i) as limited by applicable
        bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance and any other Laws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by Laws relating to the availability of specific performance,
        injunctive relief or other equitable remedies, or (iii) to the extent the indemnification provisions contained in the Registration Rights Agreement may be limited by applicable federal or state securities Laws.

     

    
       

      
        
 

    

     

    (c)       Governmental Consents and Filings. No consent, approval, order or authorization of, or
        registration, qualification, designation, declaration or filing with, any federal, state or local governmental authority is required on the part of such Purchasing Party in connection with the consummation of the transactions contemplated by this
        Agreement.

     

    (d)       Compliance with Other Instruments. The execution, delivery and performance by such
        Purchasing Party of this Agreement and the consummation by such Purchasing Party of the transactions contemplated by this Agreement will not result in any violation or default (i) of any provisions of its organizational documents, (ii) of any
        instrument, judgment, order, writ or decree to which it is a party or by which it is bound, (iii) under any note, indenture or mortgage to which it is a party or by which it is bound, (iv) under any lease, agreement, contract or purchase order to
        which it is a party or by which it is bound or (v) of any provision of federal or state statute, rule or regulation applicable to such Purchasing Party, in each case (other than clause (i)), which would have a material adverse effect on such
        Purchasing Party or its ability to consummate the transactions contemplated by this Agreement.

     

    (e)       Purchase Entirely for Own Account. This Agreement is made with such Purchasing Party in
        reliance upon such Purchasing Party’s representation to Parent, which by such Purchasing Party’s execution of this Agreement, such Purchasing Party hereby confirms, that its Backstop Shares to be acquired by such Purchasing Party will be acquired
        for investment for such Purchasing Party’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that such Purchasing Party has no present intention of selling, granting any participation
        in, or otherwise distributing the same in violation of Law. By executing this Agreement, such Purchasing Party further represents that such Purchasing Party does not presently have any contract, undertaking, agreement or arrangement with any Person
        to sell, transfer or grant participations to such Person or to any third Person, with respect to any of its Backstop Shares.

     

    (f)       Disclosure of Information. Such Purchasing Party has had an opportunity to discuss Parent’s
        existing and planned or expected business, management, financial affairs and the terms and conditions of the purchase and sale of its Backstop Shares, as well as the terms of the Transactions, with Parent’s management.

     

    (g)       Restricted Backstop Shares. Such Purchasing Party understands that the offer and sale of its
        Backstop Shares to such Purchasing Party has not been, and will not be, registered under the Securities Act, by reason of a specific exemption from the registration provisions of the Securities Act which depends upon, among other things, the bona
        fide nature of the investment intent and the accuracy of such Purchasing Party’s representations as expressed herein. Such Purchasing Party understands that its Backstop Shares are “restricted securities” under applicable U.S. federal and state
        securities Laws and that, pursuant to these Laws, such Purchasing Party must hold its Backstop Shares indefinitely unless they are registered with the SEC and qualified by state authorities, or an exemption from such registration and qualification
        requirements is available. Such Purchasing Party acknowledges that Parent has no obligation to register or qualify its Backstop Shares, or any securities into which its Backstop Shares may be converted into or exercised for, for resale, except
        pursuant to the Registration Rights Agreement. Such Purchasing Party further acknowledges that if an exemption from registration or qualification is available, it may be conditioned on various requirements including, but not limited to, the time
        and manner of sale, the holding period for its Backstop Shares, and on requirements relating to Parent which are outside of such Purchasing Party’s control, and which Parent is under no obligation and may not be able to satisfy.

     

    (h)       High Degree of Risk. Such Purchasing Party understands that its agreement to purchase its
        Backstop Shares involves a high degree of risk, which could cause such Purchasing Party to lose all or part of its investment.

     

    (i)       Accredited Investor. Such Purchasing Party is an “accredited investor” as defined in Rule
        501(a) of Regulation D promulgated under the Securities Act.

     

    (j)       No General Solicitation. Neither such Purchasing Party, nor any of its officers, directors,
        employees, agents, stockholders or partners has either directly or indirectly, including, through a broker or finder (i) to its knowledge, engaged in any general solicitation, or (ii) published any advertisement in connection with the purchase and
        sale of its Backstop Shares.

     

    
       

      
        
 

    

     

    (k)       Non-Public Information. Such Purchasing Party acknowledges its obligations under applicable
        securities Laws with respect to the treatment of material non-public information relating to Parent.

     

    (l)       Adequacy of Financing. Such Purchasing Party will have at the Share Purchase Closing
        available to it sufficient funds to satisfy its obligations under this Agreement.

     

    (m)       Affiliation of Certain FINRA Members. Such Purchasing Party is neither a person associated
        nor affiliated with any underwriter of the IPO or, to its actual knowledge, any other member of the Financial Industry Regulatory Authority (“FINRA”) that participated in the IPO.

     

    (n)       No Finder’s Fees. Such Purchasing Party is not and will not be obligated for any finder’s
        fee or commission in connection with the transactions contemplated by this Agreement.

     

    (o)        Foreign Corrupt Practices. Neither such Purchasing Party, nor any director, officer,
        agent, employee or other Person acting on behalf of such Purchasing Party has, in the course of its actions for, or on behalf of, Purchasing Party (i) used any corporate funds for any unlawful contribution, gift, entertainment or other unlawful
        expenses relating to political activity; (ii) made any direct or indirect unlawful payment to any foreign or domestic government official or employee from corporate funds; (iii) violated or is in violation of any provision of the U.S. Foreign
        Corrupt Practices Act of 1977, as amended; or (iv) made any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic government official or employee.

     

    (p)       Compliance with Anti-Money Laundering Laws. The operations of such Purchasing Party are and
        have been conducted at all times in compliance with applicable financial recordkeeping and reporting requirements and all other applicable U.S. and non-U.S. anti-money laundering Laws and regulations, including, but not limited to, those of the
        Currency and Foreign Transactions Reporting Act of 1970, as amended, the USA PATRIOT Act of 2001 and the applicable money laundering statutes of all applicable jurisdictions, the rules and regulations thereunder and any related or similar rules,
        regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the “Anti-Money Laundering Laws”), and no action, suit or proceeding by or before any court or governmental agency, authority or body or
        any arbitrator involving such Purchasing Party with respect to the Anti-Money Laundering Laws is pending or, to the knowledge of such Purchasing Party, threatened.

     

    (q)       No Other Representations and Warranties; Non-Reliance. Except for the specific
        representations and warranties contained in this Section 3 and in any certificate or agreement delivered pursuant hereto, none of such Purchasing Party nor any person acting on behalf of such Purchasing Party nor any of such Purchasing
        Party’s affiliates (“Purchasing Party Group”) has made, makes or shall be deemed to make any other express or implied representation or warranty with respect to such Purchasing Party or the purchase and sale of its Backstop Shares, and such
        Purchasing Party disclaim any such representation or warranty. Except for the specific representations and warranties expressly made by (i) Parent in Section 4 of this Agreement and in any certificate or agreement delivered pursuant hereto
        and (ii) the Company in Section 5 of this Agreement, such Purchasing Party Group specifically disclaims that it is relying upon any other representations or warranties that may have been made by Parent, any person on behalf of Parent or any of
        Parent’s affiliates (collectively, the “Parent Parties”).

     

    4.           Representations and Warranties of Parent. Parent represents and warrants to the
        Purchasing Parties as follows:

     

    (a)       Incorporation and Corporate Power. Parent is an exempted company duly incorporated, validly
        existing and in good standing under the Laws of the Cayman Islands and has all requisite corporate power and authority to carry on its business as presently conducted and as proposed to be conducted.

     

    (b)       Capitalization. The authorized share capital of Parent consists, as of the date hereof, of
        100,000,000 shares of Parent Ordinary Shares and 1,000,000 preference shares, of which 20,450,000 Parent Ordinary Shares and no Parent Preferred Shares are issued and outstanding. All of the issued and outstanding Parent Ordinary Shares and
        preference shares have been duly authorized, are fully paid and nonassessable and were issued in compliance with all applicable federal and state securities Laws.

     

    
       

      
        
 

    

     

    (c)          Authorization. All corporate action required to be taken by Parent’s Board of Directors
        and shareholders in order to authorize Parent to enter into this Agreement, and to issue the Backstop Shares at the Share Purchase Closing has been taken or will be taken prior to the Share Purchase Closing, as applicable. All action on the part of
        the shareholders, directors and officers of Parent necessary for the execution and delivery of this Agreement, the performance of all obligations of Parent under this Agreement to be performed as of the Share Purchase Closing, and the issuance and
        delivery of the Backstop Shares has been taken or will be taken prior to the Share Purchase Closing. This Agreement, when executed and delivered by Parent, shall constitute a valid and legally binding obligation of Parent, enforceable against
        Parent in accordance with its terms except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, or other Laws of general application relating to or affecting the enforcement of creditors’ rights
        generally, (ii) as limited by Laws relating to the availability of specific performance, injunctive relief, or other equitable remedies, or (iii) to the extent the indemnification provisions contained in the Registration Rights Agreement may be
        limited by applicable federal or state securities Laws.

     

    (d)          Valid Issuance of Backstop Shares.

     

    (i)       The Backstop Shares, when issued, sold and delivered in accordance with the terms and for the
        consideration set forth in this Agreement and registered in the register of members of the Company when issued in accordance with this Agreement, and registered on Parent’s share register, will be validly issued, fully paid and nonassessable and
        free of all preemptive or similar rights, liens, encumbrances and charges with respect to the issue thereof and restrictions on transfer other than restrictions on transfer specified under this Agreement, applicable state and federal securities
        Laws and liens or encumbrances created by or imposed by any Purchasing Party, as applicable. Assuming the accuracy of the representations of each Purchasing Party in this Agreement and subject to the filings described in Section 4(e) below,

        the Backstop Shares will be issued in compliance with all applicable federal and state securities Laws.

     

    (ii)       No “bad actor” disqualifying event described in Rule 506(d)(1)(i)-(viii) of the Securities Act
        (a “Disqualification Event”) is applicable to Parent or, to Parent’s knowledge, any Parent Covered Person (as defined below), except for a Disqualification Event as to which Rule 506(d)(2)(ii—iv) or (d)(3), is applicable. “Parent Covered
          Person” means, with respect to Parent as an “issuer” for purposes of Rule 506 promulgated under the Securities Act, any Person listed in the first paragraph of Rule 506(d)(1).

     

    (e)          Governmental Consents and Filings. Assuming the accuracy of the representations and
        warranties made by the Purchasing Parties in this Agreement, no consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with, any federal, state or local governmental authority is required on
        the part of Parent in connection with the consummation of the transactions contemplated by this Agreement, except for filings pursuant to Regulation D of the Securities Act, applicable state securities Laws and pursuant to the Registration Rights
        Agreement.

     

    (f)          Compliance with Other Instruments. The execution, delivery and performance of this
        Agreement and the consummation of the transactions contemplated by this Agreement will not result in any violation or default (i) of any provisions of Parent’s Governing Documents, as they may be amended from time to time, (ii) of any instrument,
        judgment, order, writ or decree to which Parent is a party or by which it is bound, (iii) under any note, indenture or mortgage to which Parent is a party or by which it is bound, (iv) under any lease, agreement, contract or purchase order to which
        Parent is a party or by which it is bound or (v) of any provision of federal or state statute, rule or regulation applicable to Parent, in each case (other than clause (i)) which would have a material adverse effect on Parent or its ability to
        consummate the transactions contemplated by this Agreement.

     

    (g)          Operations. As of the date hereof, Parent has not conducted any operations other than
        organizational activities and activities in connection with the IPO, its search for a potential business combination and financing in connection therewith.

     

    
       

      
        
 

    

     

    (h)       Foreign Corrupt Practices. Neither Parent, nor any director, officer, agent, employee or
        other Person acting on behalf of Parent has, in the course of its actions for, or on behalf of, Parent (i) used any corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to political activity; (ii)
        made any direct or indirect unlawful payment to any foreign or domestic government official or employee from corporate funds; (iii) violated or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended; or (iv)
        made any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic government official or employee.

     

    (i)       Compliance with Anti-Money Laundering Laws. The operations of Parent are and have been
        conducted at all times in compliance with applicable financial recordkeeping and reporting requirements and all other applicable U.S. and non-U.S. anti-money laundering Laws and regulations, including, but not limited to, Anti-Money Laundering
        Laws, and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving Parent with respect to the Anti-Money Laundering Laws is pending or, to the knowledge of Parent, threatened.

     

    (j)       Absence of Litigation. There is no Action before or by any Governmental Authority or, to the
        Knowledge of Parent, threatened against or affecting Parent or any of Parent’s officers or directors, whether of a civil or criminal nature or otherwise, in their capacities as such.

     

    (k)       No General Solicitation. Neither Parent, nor any of its officers, directors, employees,
        agents or shareholders has either directly or indirectly, including, through a broker or finder (i) engaged in any general solicitation, or (ii) published any advertisement in connection with the offer and sale of the Backstop Shares.

     

    (l)       No Other Representations and Warranties; Non-Reliance. Except for the specific
        representations and warranties contained in this Section 4 and in any certificate or agreement delivered pursuant hereto, none of Parent Parties has made, makes or shall be deemed to make any other express or implied representation or
        warranty with respect to Parent, the transactions contemplated by the Merger Agreement or the offer and sale of the Backstop Shares, and the Parent Parties disclaim any such representation or warranty. Except for the specific representations and
        warranties expressly made by each of the Purchasing Parties in Section 3 of this Agreement and in any certificate or agreement delivered pursuant hereto, the Parent Parties specifically disclaim that it is relying upon any other
        representations or warranties that may have been made by each Purchasing Party Group.

     

    5.           Representations and Warranties of the Company.

     

    (a)       Merger Agreement. The Company (i) represents and warrants to the Purchasing Parties that, the
        representations and warranties of the Company in the Merger Agreement are true and correct as of the date hereof and will be true and correct as of the Closing Date (other than any such representation or warranty that is made by its terms as of a
        specified date, which shall be true and correct as of such specified date), in each case, other than as would not individually or in the aggregate reasonably be expected to have a Material Adverse Effect in respect of the Company and its
        Subsidiaries and (ii) acknowledges and agrees that the Purchasing Party is relying on the accuracy of such representations and warranties as set forth in the preceding clause (i).

     

    (b)       No Other Representations and Warranties; Non-Reliance. Except for the specific representations and
        warranties contained in this Section 5 and in any certificate or agreement delivered pursuant hereto, neither the Company nor any person acting on behalf of the Company nor any of the Company’s affiliates (the “Company Group”) has made, makes or
        shall be deemed to make any other express or implied representation or warranty with respect to the Company, the transactions contemplated by the Merger Agreement or the offer and sale of the Backstop Shares, and the Company Group disclaims any
        such representation or warranty. Except for the specific representations and warranties expressly made by each Purchasing Party in Section 3 of this Agreement and in any certificate or agreement delivered pursuant hereto, the Company specifically
        disclaims that they are relying upon any other representations or warranties that may have been made by any Purchasing Party.

     

    
       

      
        
 

    

     

    6.           Additional Agreements, Acknowledgements and Waivers of the Purchasing Parties.

     

    (a)          Waiver. Reference is made to the final prospectus of Parent, dated August 3, 2020 (the “Prospectus”).

        Each Purchasing Party has read the Prospectus and understands that Parent has established the Trust Account for the benefit of the public Parent Shareholders and the underwriters of the IPO pursuant to the Trust Agreement and that, except for a
        portion of the interest earned on the amounts held in the Trust Account, Parent may disburse monies from the Trust Account only for the purposes set forth in the Trust Agreement. For and in consideration of Parent agreeing to enter into this
        Agreement, the Company and each Purchasing Party for itself and on behalf of its securityholders, hereby agrees that it does not now and shall not at any time hereafter have any right, title, interest or claim of any kind in or to any monies in the
        Trust Account as a result of, or arising out of, any negotiations, contracts or agreements with Parent and hereby agrees that it will not seek recourse against the Trust Account for any reason.

     

    (b)          No Short Sales. Each Purchasing Party hereby agrees that neither it, nor any person or
        entity acting on its behalf or pursuant to any understanding with it, will engage in any Short Sales with respect to securities of Parent prior to the Merger Closing. For purposes of this Section 5, “Short Sales” shall include,
        without limitation, all “short sales” as defined in Rule 200 promulgated under Regulation SHO under the Exchange Act and all types of direct and indirect stock pledges (other than pledges in the ordinary course of business as part of prime
        brokerage arrangements), forward sale contracts, options, puts, calls, swaps and similar arrangements (including on a total return basis), and sales and other transactions through non-U.S. broker dealers or foreign regulated brokers.

     

    7.           Share Purchase Closing Conditions.

     

    (a)          The obligation of each of the Purchasing Parties to consummate the Share Purchase Closing is
        subject to the fulfillment, at or prior to the Share Purchase Closing of each of the following conditions, any of which, to the extent permitted by applicable Laws, may be waived by the Purchasing Parties (or, with respect to clauses (ii) and
        (iii), the Company on their behalf), as applicable:

     

    (i)       The conditions set forth in Article X of the Merger Agreement (other than those conditions that
        by their nature are to be satisfied by actions taken at the Merger Closing; provided that each such condition is then capable of being satisfied at the Merger Closing on such date) to Parent’s obligations to consummate the Merger Closing have been
        satisfied or waived, and the Company has confirmed to Parent in writing that the Company is ready, willing and able to consummate the Transactions;

     

    (ii)       The representations and warranties of Parent set forth in Section 4 of this Agreement shall have
        been true and correct as of the date hereof and shall be true and correct as of the Share Purchase Closing, as applicable, with the same effect as though such representations and warranties had been made on and as of such date (other than any such
        representation or warranty that is made by its terms as of a specified date, which shall be true and correct as of such specified date), except where the failure to be so true and correct would not have a material adverse effect on Parent’s ability
        to consummate the transactions contemplated by this Agreement;

     

    (iii)       Parent shall have performed, satisfied and complied in all material respects with the
        covenants, agreements and conditions required by this Agreement to be performed, satisfied or complied with by Parent, at or prior to the Share Purchase Closing; and

     

    (iv)       No order, writ, judgment, injunction, decree, determination, or award shall have been entered by
        or with any governmental, regulatory, or administrative authority or any court, tribunal, or judicial, or arbitral body, and no other legal restraint or prohibition shall be in effect, preventing the purchase by any Purchasing Party of its Backstop
        Shares.

     

    (b)         The obligation of Parent to consummate the Share Purchase Closing is subject to the fulfillment,
        at or prior to the Share Purchase Closing of each of the following conditions, any of which, to the extent permitted by applicable Laws, may be waived by Parent (or, with respect to clauses (ii) and (iii), the Company on its behalf):

     

    
       

      
        
 

    

     

    (i)       The conditions set forth in Article X of the Merger Agreement (other than those conditions that
        by their nature are to be satisfied by actions taken at the Merger Closing; provided that each such condition is then capable of being satisfied at the Merger Closing on such date) to Parent’s obligations to consummate the Merger Closing have been
        satisfied or waived, and the Company has confirmed to Parent in writing that the Company is ready, willing and able to consummate the Transactions;

     

    (ii)       The representations and warranties of each Purchasing Party set forth in Section 3 of
        this Agreement shall have been true and correct as of the date hereof and shall be true and correct as of the Share Purchase Closing, as applicable, with the same effect as though such representations and warranties had been made on and as of such
        date (other than any such representation or warranty that is made by its terms as of a specified date, which shall be true and correct as of such specified date), except where the failure to be so true and correct would not have a material adverse
        effect on such Purchasing Party or its ability to consummate the transactions contemplated by this Agreement;

     

    (iii)       Each Purchasing Party shall have performed, satisfied and complied in all material respects
        with the covenants, agreements and conditions required by this Agreement to be performed, satisfied or complied with by such Purchasing Party at or prior to the Share Purchase Closing; and

     

    (iv)       No order, writ, judgment, injunction, decree, determination, or award shall have been entered by
        or with any governmental, regulatory, or administrative authority or any court, tribunal, or judicial, or arbitral body, and no other legal restraint or prohibition shall be in effect, preventing the purchase by any of the Purchasing Parties of the
        Backstop Shares.

     

    8.           Termination. This Agreement may be terminated at any time prior to the Share Purchase
        Closing:

     

    (a)         by mutual written consent of the parties hereto; or

     

    (b)         automatically upon the termination of the Merger Agreement in accordance with its terms.

     

    In the event of any termination of this Agreement pursuant to this Section 8, this Agreement shall
        forthwith become null and void and have no effect, without any liability on the part of any party hereto and their respective directors, officers, employees, partners, managers, members, or shareholders and all rights and obligations of each party
        shall cease; provided, however, that nothing contained in this Section 8 shall relieve either party from liabilities or damages arising out of any fraud or willful breach by such party of any of its representations,
        warranties, covenants or agreements contained in this Agreement.

     

    9.           General Provisions.

     

    (a)       Survival of Representations. Subject to the limitations and other provisions of this Agreement, the
        representations and warranties contained herein shall survive the Share Purchase Closing and shall remain in full force and effect until the first anniversary of the Closing Date.

     

    (b)       Notices. Any notice hereunder shall be sent in writing, addressed as specified below, and
        shall be deemed given: (i) if by hand, electronic mail or nationally recognized overnight courier service, by 5:00 PM Pacific Time on a Business Day, addressee’s day and time, on the date of delivery, and if delivered after 5:00 PM Eastern Time, on
        the first Business Day after such delivery; (ii) if by email, on the date of transmission with affirmative confirmation of receipt; or (iii) three (3) Business Days after mailing by prepaid certified or registered mail, return receipt requested.
        Notices shall be addressed to the respective parties as follows (excluding telephone numbers, which are for convenience only), or to such other address as a party shall specify to the others in accordance with these notice provisions:

     

    
       

      
        
 

    

     

    If to Parent, to:

     

    Health Sciences Acquisitions Corporation 2

    c/o RTW Investments, LP

    40 10th Avenue, Floor 7

    New York, New York 10014

    Attn: Legal Department

    E-mail: al@hsac2.com, gd@hsac2.com

     

    with a copy to Parent’s counsel (which shall not constitute notice) to:

     

    Loeb & Loeb LLP

        345 Park Ave

        New York, NY 10154

        Attention: Giovanni Caruso

        E-mail: gcaruso@loeb.com

     

    All communications sent to the Company shall be sent to:

     

    If to the Company, to:

     

    Orchestra BioMed, Inc.

    150 Union Square Drive

    New Hope PA 18938

    Attn; David Hochman, Chairman & CEO

        E-mail: DHochman@orchestrabiomed.com

     

    with a copy to the Company’s counsel (which shall not constitute notice)
          to:

     

    Paul Hastings LLP

    200 Park Avenue

    New York, New York 10166

    Attn: Samuel A. Waxman

    E-mail: samuelwaxman@paulhastings.com

     

    All communications to a Purchasing Party shall be sent to the Purchasing Party’s address as set forth on the signature
        page hereof, or to such e-mail address, facsimile number (if any) or address as subsequently modified by written notice given in accordance with this Section 9(a).

     

    (c)          Amendments; No Waivers; Remedies.

     

    (i)       This Agreement cannot be amended, except by a writing signed by each party, and cannot be
        terminated orally or by course of conduct. No provision hereof can be waived, except by a writing signed by the party against whom such waiver is to be enforced, and any such waiver shall apply only in the particular instance in which such waiver
        shall have been given.

     

    (ii)       Neither any failure or delay in exercising any right or remedy hereunder or in requiring
        satisfaction of any condition herein nor any course of dealing shall constitute a waiver of or prevent any party from enforcing any right or remedy or from requiring satisfaction of any condition. No notice to or demand on a party waives or
        otherwise affects any obligation of that party or impairs any right of the party giving such notice or making such demand, including any right to take any action without notice or demand not otherwise required by this Agreement. No exercise of any
        right or remedy with respect to a breach of this Agreement shall preclude exercise of any other right or remedy, as appropriate to make the aggrieved party whole with respect to such breach, or subsequent exercise of any right or remedy with
        respect to any other breach.

     

    
       

      
        
 

    

     

    (iii)       Except as otherwise expressly provided herein, no statement herein of any right or remedy shall
        impair any other right or remedy stated herein or that otherwise may be available.

     

    (d)         No Assignment or Delegation. No party may assign any right or delegate any obligation
        hereunder, including by merger, consolidation, operation of law or otherwise, without the written consent of the other parties to this Agreement. Any purported assignment or delegation without such consent shall be void, in addition to constituting
        a material breach of this Agreement.

     

    (e)         Governing Law. This Agreement and all disputes or controversies arising out of or relating
        to this Agreement or the transactions contemplated hereby, including the applicable statute of limitations, shall be governed by and construed in accordance with the Laws of the State of Delaware, without giving effect to any choice of law or
        conflict of law provision or rule (whether of the State of Delaware or any other jurisdiction) that would cause the application of the Law of any jurisdiction other than the State of Delaware.

     

    (f)         Counterparts; Facsimile Signatures. This Agreement may be executed in counterparts, each
        of which shall constitute an original, but all of which shall constitute one agreement. This Agreement shall become effective upon delivery to each party of an executed counterpart or the earlier delivery to each party of original, photocopied, or
        electronically transmitted signature pages that together (but need not individually) bear the signatures of all other parties.

     

    (g)         Entire Agreement. This Agreement, together with the agreements referenced herein, sets
        forth the entire agreement of the parties with respect to the subject matter hereof and thereof and supersedes all prior and contemporaneous understandings and agreements related thereto (whether written or oral), all of which are merged herein. No
        provision of this Agreement may be explained or qualified by any agreement, negotiations, understanding, discussion, conduct or course of conduct or by any trade usage. Except as otherwise expressly stated herein, there is no condition precedent to
        the effectiveness of any provision hereof or thereof.

     

    (h)         Severability. A determination by a court or other legal authority that any provision that
        is not of the essence of this Agreement is legally invalid shall not affect the validity or enforceability of any other provision hereof. The parties shall cooperate in good faith to substitute (or cause such court or other legal authority to
        substitute) for any provision so held to be invalid a valid provision, as alike in substance to such invalid provision as is lawful.

     

    (i)         Construction. The parties hereto have participated jointly in the negotiation and drafting
        of this Agreement. If an ambiguity or question of intent or interpretation arises, this Agreement will be construed as if drafted jointly by the parties hereto and no presumption or burden of proof will arise favoring or disfavoring any party
        hereto because of the authorship of any provision of this Agreement. Any reference to any federal, state, local or foreign Law will be deemed also to refer to Law as amended and all rules and regulations promulgated thereunder, unless the context
        requires otherwise. The words “include,” “includes” and “including” will be deemed to be followed by “without limitation.” Pronouns in masculine, feminine, and neuter genders will be construed to include any other
        gender, and words in the singular form will be construed to include the plural and vice versa, unless the context otherwise requires. The words “this Agreement,” “herein,” “hereof,” “hereby,” “hereunder” and words
        of similar import refer to this Agreement as a whole and not to any particular subdivision unless expressly so limited. The parties hereto intend that each representation, warranty and covenant contained herein will have independent significance.
        If any party hereto has breached any representation, warranty or covenant contained herein in any respect, the fact that there exists another representation, warranty or covenant relating to the same subject matter (regardless of the relative
        levels of specificity) which such party hereto has not breached will not detract from or mitigate the fact that such party hereto is in breach of the first representation, warranty or covenant.

     

    
       

      
        
 

    

     

    (j)         Remedies. Except as otherwise expressly provided herein, any and all remedies provided
        herein will be deemed cumulative with and not exclusive of any other remedy conferred hereby, or by law or equity upon a party hereto, and the exercise by a party of any one remedy will not preclude the exercise of any other remedy. The parties
        agree that irreparable damage for which monetary damages, even if available, would not be an adequate remedy would occur in the event that the parties do not perform their respective obligations under the provisions of this Agreement (including
        failing to take such actions as are required of them hereunder to consummate the transactions contemplated by this Agreement) in accordance with their specific terms or otherwise breach such provisions. It is accordingly agreed that the parties
        shall be entitled to an injunction or injunctions, specific performance and other equitable relief to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement, in each case, without posting a bond or
        undertaking and without proof of damages and this being in addition to any other remedy to which they are entitled at law or in equity. Each of the parties agrees that it will not oppose the granting of an injunction, specific performance and other
        equitable relief when expressly available pursuant to the terms of this Agreement on the basis that the other parties have an adequate remedy at law or an award of specific performance is not an appropriate remedy for any reason at law or equity.

     

    [Signature Page Follows]

      

     

    
       

      
        
 

    

     

    IN WITNESS WHEREOF, the undersigned have executed this Agreement to be effective as of the date
        first set forth above.

     

    	 	PURCHASING PARTIES:
	 	 
	 	RTW MASTER FUND, LTD.
	 	 
	 	By:	/s/ Roderick Wong
	 	Name: Roderick Wong, M.D.
	 	Title: Director
	 	 
	 	RTW INNOVATION MASTER FUND, LTD.
	 	 
	 	By:	/s/ Roderick Wong
	 	Name: Roderick Wong, M.D.
	 	Title: Director
	 	 
	 	RTW VENTURE FUND LIMITED
	 	 
	 	By: RTW Investments, LP, its Investment Manager
	 	 
	 	By:	/s/ Roderick Wong
	 	Name: Roderick Wong, M.D.
	 	Title: Managing Partner
	 	 
	 	Address for Notices:
	 	40 10th Avenue, Floor 7
	 	New York, NY 10014

     

    
       

      
        
 

    

     

    	 	PARENT:
	 	Health Sciences Acquisitions Corporation 2
	 	 	 	 
	 	By:	/s/ Roderick Wong
	 	 	Name:	Roderick Wong, M.D.
	 	 	Title:	President and Chief Executive Officer

     

    
       

      
        
 

    

     

    	 	COMPANY
	 	Orchestra BioMed, Inc.
	 	 	 	 
	 	By:	/s/ David Hochman
	 	 	Name:	David Hochman
	 	 	Title:	Chief Executive Officer

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