Document:

Fourth Amendment to the Amended and Restated Strategic Alliance Agreement

 Exhibit 10.18.3 

FOURTH AMENDMENT 

TO THE AMENDED AND RESTATED STRATEGIC ALLIANCE AGREEMENT 

This Fourth Amendment to the Amended and Restated Strategic Alliance Agreement (this “Amendment”), effective as of
April 8, 2010 (the “Amendment Date”) is made by and among Penwest Pharmaceuticals Co., a Washington Corporation with its principal place of business at 2981 Route 22, Patterson, New York 12563 (“Penwest”) and
Endo Pharmaceuticals Inc., a Delaware corporation with its principal place of business at 100 Endo Boulevard, Chadds Ford, Pennsylvania 19317 (“Endo”), and amends the Amended and Restated Strategic Alliance Agreement, dated
April 2, 2002, between Penwest and Endo (as amended) (the “Strategic Alliance Agreement”). Penwest and Endo are referred to in this Amendment as the “Parties” and individually as a “Party”. Any
capitalized terms used but not defined herein will have the meaning ascribed to such terms in the Strategic Alliance Agreement. 

RECITALS 

WHEREAS, Penwest and Endo are parties to the Strategic Alliance Agreement, pursuant to which the Parties intended that Endo would have an
exclusive license to certain Penwest Product Technology, Penwest Patents and Penwest Confidential Information in the relevant field of use; 

WHEREAS, on June 22, 2006, the FDA approved Endo’s new drug application No. 21-610 for
OPANA® ER tablets, which contain oxymorphone hydrochloride, under § 505(b) of the Federal Food, Drug and
Cosmetic Act, 21 U.S.C. § 355(b), for the relief of moderate-to-severe pain in patients requiring continuous, around-the-clock opioid treatment for an extended period of time; 

WHEREAS, Endo submitted information regarding certain of the Penwest patents (including United States Patent Nos.
5,662,933 (the “‘933 Patent”) and 5,958,456 (the “‘456 Patent” and each of the ‘933 Patent and the ‘456 Patent, a “Patent”))) to the FDA for listing in its publication, the
Approved Drug Products with Therapeutic Equivalence Evaluations (referred to as the “Orange Book”), with respect to
OPANA® ER tablets; 

WHEREAS, at least six generic companies have filed Abbreviated New Drug Applications (“ANDAs”)
seeking approval to engage in the commercial manufacture, use, and sale of oxymorphone hydrochloride extended-release tablets, as generic versions of
OPANA® ER tablets, prior to the expiration of certain of the Penwest Patents (as defined in the Strategic
Alliance Agreement) listed in the Orange Book with respect thereto; 
 WHEREAS, Endo and Penwest have brought suit against each
of those generic companies pursuant to the Hatch-Waxman Act for infringement of the ‘456 and/or ‘933 Patents, and in each instance, Endo and Penwest alleged that Penwest is the owner and assignee of those Patents, and that Endo is an
exclusive licensee of the Patents in the relevant field of use pursuant to the Strategic Alliance Agreement with Penwest; 

 WHEREAS, Endo and Penwest reached an agreement to settle their claims against Actavis South
Atlantic LLC (“Actavis”), one of the generic companies they sued for patent infringement, and in connection therewith, entered into a Settlement and License Agreement with Actavis; 

WHEREAS, pursuant to the Settlement and License Agreement with Actavis, Endo and Penwest granted Actavis a non-exclusive license to the
‘456 Patent, effective as of the Commencement Date defined therein (“Actavis License Commencement Date”), along with a covenant not to sue Actavis for infringement of the ‘933 Patent with respect to certain activities that
Actavis may undertake on or after the Actavis License Commencement Date; 
 WHEREAS, the Actavis License Commencement Date has
not yet occurred, such that there is no person or entity other than Endo that has a license to the ‘456 or ‘933 Patents within the relevant field of use which is effective as of the Amendment Date; 

WHEREAS, Impax Laboratories, Inc. (“Impax”), one of the generic companies that Endo and Penwest have sued for patent
infringement, recently asserted for the first time that Endo lacks standing to sue for infringement of the ‘456 and ‘933 Patents because it does not have an appropriate exclusive license to those Patents within a relevant field of use;

 WHEREAS, Endo and Penwest disagree with Impax, and hereby confirm that it was and always has been the Parties’ intent
that Endo would have an exclusive license to the Penwest Patents (as defined in the Strategic Alliance Agreement), including the ‘456 and ‘933 Patents, in the relevant field of use; 

WHEREAS, to clarify their intent and in order avoid further litigation and expense over Endo’s standing to sue for infringement of
the ‘456 and ‘933 Patents, the Parties hereby enter into this Amendment; 
 NOW, THEREFORE, in consideration of the
foregoing and the mutual covenants set forth below, the Parties agree as follows: 
 1. Amendments to Strategic Alliance Agreement.
Penwest and Endo hereby amend the Strategic Alliance Agreement as follows, solely with respect to the United States, such amendments to become effective as of the Amendment Date: 

(a) Endo License. Section 6 of the Strategic Alliance Agreement is amended by adding the following: 

“6.3.1.1. Subject to the non-exclusive license granted to Actavis pursuant to the Actavis Settlement and License Agreement, which
license is not effective as of the Amendment Date and shall not become effective until the Actavis License Commencement Date, Penwest hereby grants to Endo an exclusive license under the 

 

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Penwest Patents to Endo to make, have made, use, sell, offer for sale, and import in the United States solid-dosage forms of extended-release pharmaceutical products for oral administration in
humans containing Oxymorphone (or Oxymorphone metabolites, Oxymorphone derivatives and/or Oxymorphone salts) as the only active therapeutic drug substance (but excluding the Product) which fall within the scope of the Penwest Patents
(“Licensed Oxymorphone Product”). Such license does not extend to the making of TIMERx or Formulated TIMERx (which is covered by Section 6.6 hereto), but does cover the incorporation of the same into any Licensed Oxymorphone
Product and the sale of the same as part of the Licensed Oxymorphone Product. Such license shall be exclusive even as to Penwest and its Affiliates, and Endo shall have the right to grant sublicenses under this Section 6.3 with the prior
written consent of Penwest, which consent shall not be unreasonably withheld. Penwest will, throughout the License Term, promptly notify Endo of all Penwest Patents referred to in Section 1.32 of the Definitions Exhibit and provide Endo with
access to all of the same, solely for use within the scope of the license stated in this section.” 
 (b) Endo’s
Continuing License. Section 6.7 of the Strategic Alliance Agreement is amended by adding the words “and Licensed Oxymorphone Products” after the first three occurrences of the word “Product” (i.e., through
Section 6.7.2) in such Section. 
 (c) Infringement. Section 11.1 of the Strategic Alliance Agreement is
amended by replacing the first sentence of such Section in its entirety with the following: 
 “11.1 Notice of
Infringement. Penwest shall promptly inform Endo of any suspected infringement of any of the Penwest Patents or Penwest Product Technology Patents or the infringement or misappropriation of the TIMERx Production Technology or Penwest Product
Technology by a third party, to the extent such infringement or misappropriation involves the manufacture, use or sale of the Product, a substitutable or directly competitive product in the Territory, or any Licensed Oxymorphone Product
(“Covered Infringement”).” 
 (d) Patent Enforcement Litigation. Section 11.7 of the Strategic
Alliance Agreement is amended by adding the words “or a Licensed Oxymorphone Product” after each occurrence of the word “Product” in such Section. 

(e) Definition of Exclusivity Period. Section 1.20 of the Definitions Exhibit of the Strategic Alliance Agreement is amended
by adding the words “and Licensed Oxymorphone Products” after the word “Product” in such Section. 
 (f)
Financials for Licensed Oxymorphone Product. Sections 1.45, 4.5.1, 4.6.1, 4.8 and 4.11 of the Strategic Alliance Agreement are amended by adding the words “or Licensed Oxymorphone Product” after each occurrence of the word
“Product” in such Sections. 
  

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 2. Entire Agreement. Except as expressly amended by this Amendment, no other portion of the Strategic
Alliance Agreement is amended and all of the terms, covenants and conditions of the Strategic Alliance Agreement shall remain in full force and effect to the same extent as if fully set forth herein. For the avoidance of doubt, nothing in
Section 1 shall amend the Strategic Alliance Agreement with respect to any country in the Territory other than the United States, and Section 6.4 of the 2002 Agreement shall continue to operate as it did immediately prior to the 2007
Amendment Effective Date. The Parties agree that all references in the Strategic Alliance Agreement to “this Agreement” shall be deemed to include the provisions of this Amendment. 

3. Governing Law. This Amendment and all matters or issues collateral thereto shall be governed by and construed in accordance with the laws of
the State of New York without regard to its conflict of laws rules. 
 4. Counterparts. This Amendment may be executed in one or more
counterparts, each of which shall constitute an original but all of which together shall constitute but a single document. 
 IN
WITNESS WHEREOF, the Parties hereto have caused this Amendment to be duly executed as of the day and year first above written. 
  

									
	PENWEST PHARMACEUTICALS CO.	 		 	ENDO PHARMACEUTICALS INC.
					
	By:	 	/S/ JENNIFER L. GOOD	 		 	By:	 	/S/ CAROLINE B. MANOGUE
	Name:	 	Jennifer L. Good	 		 	Name:	 	Caroline B. Manogue
	Title:	 	President and CEO	 		 	Title:	 	Executive VP, Chief Legal Officer, and Secretary

  

 4First Amendment to the Amended and Restated Tax Benefit Preservation Plan

 Exhibit 4.1 

FIRST AMENDMENT TO THE 

AMENDED AND RESTATED TAX BENEFIT PRESERVATION PLAN 

This First Amendment to the Amended and Restated Tax Benefit Preservation Plan (this “Amendment”) dated as of
May 3, 2010, is entered into between Radian Group Inc., a Delaware corporation (the “Company”), and The Bank of New York Mellon, a New York banking corporation, as Rights Agent (the “Rights Agent”). 

Background 

A. The Company and Rights Agent are parties to that certain Amended and Restated Tax Benefit Preservation Plan, dated as of
February 12, 2010 (the “Preservation Plan”). 
 B. The Company wishes to amend the Preservation Plan to
add a termination provision if the Preservation Plan is not re-approved by the stockholders of the Company every three years. 

NOW, THEREFORE, in consideration of the mutual promises, agreements and covenants set forth herein, and for other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as follows: 

1. Amendment. The Preservation Plan shall be amended by inserting a new provision (Section 7(f)) that reads in its entirety as follows:

 In addition to the provision set forth in Section 7(a) of this Plan, the Expiration Date shall occur on the Close of
Business on the second Business Day after the final adjournment of the third consecutive annual meeting of the stockholders of the Company held after this Plan was most recently approved by the stockholders of the Company unless the Plan is
re-approved by the stockholders at such meeting. 
 2. Counterparts. This Amendment may be executed in any number of counterparts and
each of such counterparts shall for all purposes be deemed to be an original, and all such counterparts shall together constitute but one and the same instrument. A signature to this Amendment transmitted electronically shall have the same
authority, effect and enforceability as an original signature. 
 3. Severability. If any term, provision, covenant or restriction of
this Amendment or applicable to this Amendment is held by a court of competent jurisdiction or other authority to be invalid, null and void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment shall
remain in full force and effect and shall in no way be affected, impaired or invalidated; and provided, further, that if any such excluded term, provision, covenant or restriction shall adversely affect the rights, immunities, duties
or obligations of the Rights Agent, the Rights Agent shall be entitled to resign immediately. 

 4. Governing Law. This Amendment shall be deemed to be a contract made under the laws of the State of
Delaware and for all purposes shall be governed by and construed in accordance with the laws of such State applicable to contracts to be made and performed entirely within such State. 

5. Descriptive Headings. Descriptive headings of the several sections of this Amendment are inserted for convenience only and shall not control or
affect the meaning or construction of any of the provisions hereof. 
 6. Defined Terms. All capitalized terms used herein and not
otherwise defined shall have the meaning given to them in the Preservation Plan. 
 7. Preservation Plan in Full Force and Effect as
Amended. Except as specifically amended hereby, all of the terms and conditions of the Preservation Plan shall be in full force and effect. All references to the Preservation Plan in any other document or instrument shall be deemed to mean such
Preservation Plan as amended by this Amendment. The parties hereto agree to be bound by the terms and obligations of the Preservation Plan, as amended by this Amendment, as though the terms and obligations of the Preservation Plan were set forth
herein. 
 [Signatures of the parties intentionally appear on the next page.] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed as of
the 3rd day of May, 2010. 
  

					
	RADIAN GROUP INC.
		
	By:	 	 /s/ C. Robert Quint

		 	Name:	 	C. Robert Quint
		 	Title:	 	Chief Financial Officer
	
	THE BANK OF NEW YORK MELLON,
		 	as Rights Agent
		
	By:	 	 /s/ Kieran McGovern

		 	Name:	 	Kieran McGovern
		 	Title:	 	Senior Associate

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