Document:

Exhibit 10.50

 

	
Confidential   Treatment Requested
   Under 17 C.F.R. §§ 200.80(b)(4) and 240.24b-2
    	

    

 

CHANGE ORDER

 

LETTER OF PAYMENT AUTHORIZATION

 

14 Nov 2012

 

Gary Hattersley, Ph.D.

Vice President, Biology

RADIUS HEALTH, INC.

5th Floor

300 Technology Square

Cambridge, MA 02139

United States

 

	
RE:
    	
 
    	
STUDY   #    20033374
    	
 
    	
BLOOD   SAMPLE COLLECTION FROM FEMALE NON-HUMAN PRIMATES FOLLOWING A SINGLE   SUBCUTANEOUS DOSE OR TRANSDERMAL PATCH DOSE OF BA058
    
	
 
    	
 
    	
FINAL   PROTOCOL AND PROTOCOL AMENDMENT 1
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
STUDY   START:
    	
09 OCT   2012
    	
 
    	
STUDY   END:
    	
25   OCT 2012
    

 

Dear Dr. Hattersley,

 

This communication is to serve as a Letter of Payment Authorization (LOPA) for the above referenced study, which will be performed at Charles River Laboratories Preclinical Services as set forth below. Charles River Laboratories Preclinical Services shall perform these services in accordance with the existing Service Agreement executed between Charles River Laboratories Preclinical Services and Radius Health, Inc.  Once fully executed, this LOPA shall be incorporated into and made part of the existing Service Agreement.

 

The payment schedule and price of this Final Protocol and Protocol Amendment Adjustment is as follows:

 

	
·   $ [*]
    	
Final   Protocol Adjustment on Study 
    
	
 
    	
 
    
	
·   $ [*]
    	
Protocol   Amendment 1 Adjustment on Study
    
	
 
    	
 
    
	
·   $ [*]
    	
Total   Cost 
    
	
 
    	
 
    
	
·   $ 11,856
    	
Total   Cost with [*]% discount — Due upon adjustment billing
    

 

Total study cost:  $82,344

 

Final Protocol adjustment due to:

·                  Increased number of blood sample collections and processing

 

Protocol Amendment 1 adjustment due to:

·                  An additional dose day was added to the study design

·                  Increased number of blood sample collections and processing

·                  Additional dose site observations added

 

In the event the study design is altered, or the study is postponed or cancelled, payments will be amended as follows:

 

The price impact (if any) of the protocol amendment/change order will be submitted in writing.  If study prices increase the difference will be invoiced and payable upon acceptance by the Sponsor.  If study prices decrease, the Sponsor will be credited for the difference.

 

Charles River, 6995 Longley Lane, Reno, NV 89511

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

Form No. LC-08-F04 Revised 05-18-06

 

 

As acceptance of this agreement, please sign this Letter of Payment Authorization and return to me at the letterhead address or fax to me at 775-682-2100.  Should you have any questions, please call me at 775-682-2386.

 

 

	
/s/   Gary Hattersley
    	
 
    	
/s/   Danielle M. Florey
    
	
Authorized   Sponsor Representative 
    	
 
    	
Danielle   M. Florey
    
	
 
    	
 
    	
Client Manager, Client Services  
    
	
Gary   Hattersley, SVP Preclinical Development
    	
 
    	
14 Nov 2012
    
	
Print   (Name and Title)
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
November 15,   2012
    	
 
    	
 
    
	
Date
    	
 
    	
 
    

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

Charles River, 6995 Longley Lane, Reno, NV 89511

 

2Exhibit 10.25

 

SECOND AMENDMENT TO

EMPLOYMENT AGREEMENT

 

This SECOND AMENDMENT TO EMPLOYMENT AGREEMENT (this “Amendment”) is entered into effective as of January 24, 2013, by and between SCOTT K. GINSBURG (“Executive”) and DIGITAL GENERATION, INC., a Delaware corporation (the “Company”).  Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Agreement (as defined below).

 

WHEREAS, the Company and Executive are parties to that certain Employment Agreement effective as of January 1, 2012, as amended by that certain Amendment to Employment Agreement dated as of March 29, 2012 (together, the “Agreement”); and

 

WHEREAS, the Company and Executive desire to amend the Agreement on the terms and conditions set forth below.

 

NOW, THEREFORE, in consideration of the foregoing, and for other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, the Company and Executive hereby amend the Agreement as follows:

 

1.                                      Section 6(b) of the Agreement is hereby amended to read as follows:

 

(b)                                 “Change in Control” shall mean and include each of the following:

 

(i)                                     any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”)) is or becomes the “beneficial owner” (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 50% or more of the combined voting power of the Company’s then outstanding securities;

 

(ii)                                  the majority of the Board is composed of members who either (A) have served less than 12 months, and were not approved by a majority of the Board at the time of their election or appointment, and/or (B) were nominated by the Board, or otherwise appointed or elected by or to the Board, pursuant to or in connection with an agreement or understanding to forestall or settle (or otherwise not pursue) a proxy contest or one or more stockholder proposals to amend (or otherwise relating to) the Company’s bylaws, certificate of incorporation or other documents or policies addressing the governance of the Company or rights of Company stockholders;

 

(iii)                               the merger or consolidation of the Company with or into another entity or the merger of another entity into the Company or any subsidiary thereof with the effect that immediately after such transaction the stockholders of the Company immediately prior to such transaction (or their affiliates) hold less than 50% of the total voting power of all securities generally entitled to vote in the election of directors, managers or trustees of the entity surviving such merger or consolidation;

 

 

(iv)                              a tender offer or exchange offer is made and consummated for the ownership of securities of the Company representing 50% or more of the combined voting power of the Company’s then outstanding voting securities; or

 

(v)                                 the sale, lease or other transfer of all or substantially all of the assets of the Company to any person or group (as such term is used in Section 13(d)(3) of the Exchange Act).

 

2.                                      This Amendment shall be and is hereby incorporated in and forms a part of the Agreement.  All other terms and provisions of the Agreement shall remain unchanged except as specifically modified herein.  The Agreement, as amended by this Amendment, is hereby ratified and confirmed.

 

[Signature Page Follows]

 

2

 

IN WITNESS WHEREOF, the Company and Executive have executed and delivered this Amendment on the date(s) set forth below.

 

 

	
 
    	
DIGITAL   GENERATION, INC.
    
	
 
    	
 
    
	
 
    	
 
    	
 
    
	
Date: January 31, 2013
    	
By:  
    	
/s/   Neil Nguyen
    
	
 
    	
Name:
    	
Neil   Nguyen
    
	
 
    	
Title:
    	
President   and Chief Executive Officer 
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
EXECUTIVE
    
	
 
    	
 
    
	
 
    	
 
    
	
Date: February 4, 2013
    	
/s/ Scott K. Ginsburg
    
	
 
    	
Scott   K. Ginsburg
    

 

3Exhibit 10.26

 

SECOND AMENDMENT TO

EMPLOYMENT AGREEMENT

 

This SECOND AMENDMENT TO EMPLOYMENT AGREEMENT (this “Amendment”) is entered into effective as of January 24, 2013, by and between NEIL H. NGUYEN (“Executive”) and DIGITAL GENERATION, INC., a Delaware corporation (the “Company”).  Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Agreement (as defined below).

 

WHEREAS, the Company and Executive are parties to that certain Employment Agreement effective as of January 1, 2012, as amended by that certain Amendment to Employment Agreement dated as of March 29, 2012 (together, the “Agreement”); and

 

WHEREAS, the Company and Executive desire to amend the Agreement on the terms and conditions set forth below.

 

NOW, THEREFORE, in consideration of the foregoing, and for other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, the Company and Executive hereby amend the Agreement as follows:

 

1.                                      Section 6(b) of the Agreement is hereby amended to read as follows:

 

(b)                                 “Change in Control” shall mean and include each of the following:

 

(i)                                     any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”)) is or becomes the “beneficial owner” (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 50% or more of the combined voting power of the Company’s then outstanding securities;

 

(ii)                                  the majority of the Board is composed of members who either (A) have served less than 12 months, and were not approved by a majority of the Board at the time of their election or appointment, and/or (B) were nominated by the Board, or otherwise appointed or elected by or to the Board, pursuant to or in connection with an agreement or understanding to forestall or settle (or otherwise not pursue) a proxy contest or one or more stockholder proposals to amend (or otherwise relating to) the Company’s bylaws, certificate of incorporation or other documents or policies addressing the governance of the Company or rights of Company stockholders;

 

(iii)                               the merger or consolidation of the Company with or into another entity or the merger of another entity into the Company or any subsidiary thereof with the effect that immediately after such transaction the stockholders of the Company immediately prior to such transaction (or their affiliates) hold less than 50% of the total voting power of all securities generally entitled to vote in the election of directors, managers or trustees of the entity surviving such merger or consolidation;

 

 

(iv)                              a tender offer or exchange offer is made and consummated for the ownership of securities of the Company representing 50% or more of the combined voting power of the Company’s then outstanding voting securities; or

 

(v)                                 the sale, lease or other transfer of all or substantially all of the assets of the Company to any person or group (as such term is used in Section 13(d)(3) of the Exchange Act).

 

2.                                      This Amendment shall be and is hereby incorporated in and forms a part of the Agreement.  All other terms and provisions of the Agreement shall remain unchanged except as specifically modified herein.  The Agreement, as amended by this Amendment, is hereby ratified and confirmed.

 

[Signature Page Follows]

 

2

 

IN WITNESS WHEREOF, the Company and Executive have executed and delivered this Amendment on the date(s) set forth below.

 

 

	
 
    	
DIGITAL   GENERATION, INC.
    
	
 
    	
 
    
	
 
    	
 
    	
 
    
	
Date: January 28, 2013
    	
By:  
    	
/s/   Sean Markowitz
    
	
 
    	
 Name:
    	
Sean   Markowitz
    
	
 
    	
Title:
    	
General   Counsel 
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
EXECUTIVE   
    
	
 
    	
 
    
	
 
    	
 
    
	
Date: January 31, 2013
    	
/s/   Neil Nguyen
    
	
 
    	
Neil   Nguyen
    

 

3

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