Document:

Fifth Lease Amendment

 Exhibit 10.15(a) 
 FIFTH LEASE AMENDMENT 
 between 
 BENAROYA CAPITAL COMPANY, LLC 
 and 
 TARGETED GENETICS CORPORATION 
 This Fifth Lease
Amendment dated January 8, 2004, is attached to and made part of that certain Lease dated October 7, 1996, as amended in that Fourth Lease Amendment dated March 28, 2001, that Third Lease Amendment dated April 19, 2000, that
Second Lease Amendment dated February 25, 2000, and that First Lease Amendment, dated May 12, 1997 (the “Lease”), by and between Benaroya Capital Company, LLC, a Washington limited liability company (the “Lessor”), and
Targeted Genetics Corporation, a Washington corporation (the “Lessee”), covering Suites 100 and 1200 located in the property commonly known as the Metropolitan Park West Tower, located at 1100 Olive Way, Seattle, Washington (the
“Premises”). The Premises are more particularly described in the Lease. The terms used herein shall have the same definitions as set forth in the Lease. 
 NOW THEREFORE, in consideration of the mutual covenants and promises contained in this Fifth Lease Amendment and the Lease, Lessor and Lessee agree as follows: 
  

	1.	Section 1, Premises. Effective April 1, 2004, Section 1, Premises, of the Lease is deleted and replaced with the following: 

 “Lessor does hereby lease to Lessee those certain Premises, to wit: approximately 13,556 square feet of office space located on the first floor in
Suite 100 (4,990 square feet) and on the twelfth floor in Suite 1200 (8,566 square feet) as outlined on Exhibit A and Exhibit A-1, respectively, attached to this Fifth Lease Amendment (hereinafter called the “Premises”) being situated
within the project known as the Metropolitan Park West Tower.” The useable square foot area of suite 100 is 4,825 square feet and the current load factor per 1996 BOMA is 3.42%. The useable area for suite 1200 is 7762 useable square feet and
the current load factor per 1996 BOMA is 10.36%. 
  

	2.	Section 2, Term. The term of the Lease is hereby extended for five (5) years, commencing April 1, 2004 and expiring March 31, 2009.

  

	3.	Section 3, Monthly Minimum Rent. Section 3, Monthly Minimum Rent, is amended as follows: 

  

				
	 Period
	  	Monthly Minimum Rent
	 April 1, 2004—March 31, 2005
	  	$	22,593.00
	 April 1, 2005—March 31, 2006
	  	$	23,441.00
	 April 1, 2006—March 31, 2007
	  	$	24,288.00
	 April 1, 2007—March 31, 2008
	  	$	25,135.00
	 April 1, 2008—March 31, 2009
	  	$	25,982.00

  

	4.	Section 10, Additional Rent and Monthly Operating Expense Adjustments. Section 10 of the Lease, as previously amended, is hereby further amended as follows:

 a) Effective April 1, 2004, Lessee’s prorata share of operating expenses will be 4.022%. 
  

 1 

 b) Effective April 1, 2004, the Base Year for operating expenses will be changed to 2004.

  

	5.	Exhibit G, Paragraph 1, Option to Renew. Exhibit G, Paragraph 1, Option to Renew is hereby deleted and replaced with the following: 

 “Provided Lessee is not in default of any material term or condition of the Lease (unless the default was cured within the applicable cure period),
Lessee shall have two (2) consecutive Options to Extend the lease term, one (1) period of thirty-six (36) months and, if exercised, followed by one (1) additional period of twenty-four (24) months (“Option Terms”),
upon the same terms and conditions as are set forth in the Lease, except for the Monthly Minimum Rent which shall be determined as set forth below and except that the Option to Cancel provisions shall not thereafter apply. The first option shall be
exercised, if at all, by written notice to Lessor before August 1, 2008, and if applicable, the second option shall be exercised, if at all, by written notice to Lessor before August 1, 2011 
 The rent shall be the fair market rent as agreed by Lessee and Lessor. Upon receipt of
Lessee’s notice to extend, Lessor shall provide Lessee notice stating the rental rate it would be willing to accept for the extended term (the “Lessor’s Notice Rate”). Lessee shall have ten (10) days after receipt of
Lessor’s Notice Rate to accept or reject such rate. In the event Lessee rejects the Lessor’s Notice Rate such rejection shall state the rate that Lessee would be willing to pay for the extended term (the “Lessee’s Notice
Rate”). If the parties fail to agree on the fair market rental rate, then within two (2) days thereafter each party shall select an appraiser and the two appraisers shall within ten (10) days appoint a third appraiser (the
“Determining Appraiser”). The Determining Appraiser shall make an independent determination of the rental rate for the extended term (the “New Rent”) which shall be the average prevailing rental rate for comparable space. The
parties agree that for purposes of determining the New Rent, they will attempt to obtain the economic terms of any leases signed within the prior six (6) months for space on the first floors and the upper 35% of the floors of facilities within
the perimeter of Denny Road to the North, Pike Street to the South, Interstate 5 to the East and 3rd Avenue to the West. New Rent will be computed
based on facilities within such geographic perimeter of comparable size, condition, age, in-building parking facilities, freeway access, central HVAC systems, views and for comparable floors and square footage. No leases in buildings without central
HVAC and modern in-building parking will be considered. The Determining Appraiser will be instructed to contact the owners of those buildings, obtain the most recent lease rates for the applicable space, average the result (if there are more than
one) and produce the figure which shall be considered the “New Rent” and which determination will be binding on the parties. The party whose Notice Rate is furthest from the appraiser’s New Rent shall pay the fee of the appraiser.
Lessor shall prepare and Lessee shall execute a lease amendment for extension within thirty (30) days after determination of the New Rent.” 
  

	6.	 Exhibit G, Paragraph 2, Right of First Offer. Provided Lessee is not in default of any material term or condition of the Lease (unless the default was
cured within the applicable cure period), Lessee shall have the Right of First Offer to lease any space that is or will become available for lease on the first, twelfth, and adjacent floors of the Metropolitan Park West Tower, subject to any rights
existing prior to the date of this Lease Amendment. Lessee shall have the Right of First offer for the term of the Lease. Prior to entering into negotiations for the space that Lessee has a Right of First offer on, Lessor shall provide Lessee with
written notification specifying when the space shall be available for occupancy and the terms and conditions under which Lessor will lease the space (the “First Right Notice”). Lessee shall respond within ten (10) days of written
notification by Lessor if Lessee wishes to lease the space. If Lessee does not respond 

  

 2 

	 	 
within ten (10) days, Lessee shall be deemed to have rejected the offer to lease the space. Should Lessee accept such offer to lease, Lessee shall
execute a Lease Amendment to such effect within ten (10) days after delivery of the Lease Amendment to Lessee. If Lessee does not accept the offer, then Lessor shall be free to lease the space to a third party on terms that are not materially
more favorable to the tenant than those specified in the First Right Notice. For the purpose of this provision “materially more favorable” shall mean that the net effective rental rate (including tenant improvement allowances and other
economic concessions, if any), to the third party would be more than ten percent 10% less than the net effective rate after factoring in all concessions provided, or not, by Lessor under the terms contained in the First Right Notice. In the event
that the net effective rental rate to the third party would be materially more favorable than that provided in the First Right Notice, Lessor will provide Lessee with a new notice (the “Revised First Right Notice”) offering to lease the
space to Lessee on the terms specified in the third party proposal. The same procedure will apply with regard to the Revised First Right Notice; except the notice period which will be five (5) business days following receipt rather than ten
(10) days. 

  

	7.	Exhibit G, Paragraph 4, Parking. Effective April 1, 2004, Lessee shall be entitled to lease a total of fourteen (14) parking stalls for the term of the
Lease. All parking shall be located in the Building Garage, in the Metropolitan North Garage, Metropolitan East Garage, or on nearby surface lots and will be at market rates. 

  

	8.	Option to Cancel Lease. Provided Lessee has not been in default of any material term or condition of the Lease on the date of the notice described below on or before
the date of Lease cancellation, Lessee shall have the Option to Cancel this Lease at any time after April 1, 2006. Lessee shall provide not less than eight (8) months prior written notice of its election to cancel. Along with its
cancellation notice, Lessee shall pay Lessor a Lease cancellation fee in an amount equal to the sum of: (i) thirty five percent (35%) of Rent due from the effective date of the lease cancellation through April 1, 2007, if any, plus
(ii) twenty-five percent (25%) of the Rent for the period from April 1, 2007 to March 31, 2009, plus (iii) the unamortized portion of the lease commission. 

  

	9.	Lessee Broker Representation. Both parties acknowledge that Lessee has engaged Staubach to represent it in this Agreement, hereinafter referred to as
“Broker.” Broker’s sole compensation for representing Lessee shall be paid by Lessor in accordance with the terms of the Commission Agreement dated November 10, 2003 between Broker and Lessor. 

 Except as otherwise modified by the terms of this Fifth Lease Amendment, all other terms and conditions of the Lease remain unchanged and in full force and effect.

  

									
	LESSOR:	 		 	LESSEE:
			
	BENAROYA CAPITAL COMPANY, LLC	 		 	TARGETED GENETICS CORPORATION
			
	 /s/ Larry Benaroya
	 		 	 /s/ Todd Simpson

		 		 	 (SIGNATURE)

					
	By:	 	Larry Benaroya	 		 	By:	 	 Todd Simpson

		 		 		 		 	 (PLEASE PRINT)

					
	Its:	 	Manager	 		 	Its:	 	 VP Finance & CFO

					
	Date:	 	 1/9/04
	 		 	Date:	 	 January 8, 2004

  

 3 

					
	 STATE OF WASHINGTON
	  	]	  	
		  	]	  	ss.
	 COUNTY OF KING
	  	]	  	

 I certify that I know or have satisfactory evidence that Larry R. Benaroya is the person who
appeared before me, a Notary Public in and for the State of Washington duly commissioned and sworn, and acknowledged that he is the manager of Benaroya Capital Company, LLC, a Washington limited liability company, who executed the within and
foregoing instrument, and acknowledged the instrument to be the free and voluntary act and deed of said company for the uses and purposes therein mentioned, and on oath stated that affiant is authorized to execute said instrument on behalf of said
company. 
 IN WITNESS WHEREOF I have hereunto set my hand and affixed my official seal this 9th day of January, 2004. 
  

							
	 [NOTARY SEAL]
	 		 	 /s/ LORI JO GOODMAN
	 	
		 		 	Notary Public in and for the	 	
		 		 	State of    Washington                              
                               	 	
		 		 	residing at    Seattle                               
                                  	 	
		 		 	Commission expires   4-9-07                               
                   	 	
		 		 	Print Name    LORI JO GOODMAN                             
         	 	

  

					
	 STATE OF Washington
	  	]	  	
		  	]	  	ss.
	 COUNTY OF King
	  	]	  	

 I certify that I know or have satisfactory evidence that Todd E. Simpson is the person who
appeared before me, a Notary Public in and for the State of Washington duly commissioned and sworn, and acknowledged that he/she is the VP Finance & CFO of Targeted Genetics Corporation, a Washington Corporation, who executed
the within and foregoing instrument, and acknowledged the instrument to be the free and voluntary act and deed of said corporation for the uses and purposes therein mentioned, and on oath stated that affiant is authorized to execute said instrument
on behalf of said corporation. 
 IN WITNESS WHEREOF I have hereunto set my hand and affixed my
official seal this 8th day of January, 2004. 
  

							
		 		 	 /s/ BEVERLY J ECKERT
	 	
		 		 	Notary Public in and for the	 	
		 		 	State of    Washington                              
                                	 	
		 		 	residing at    Seattle                               
                                   	 	
		 		 	Commission expires   3-19-05                               
                  	 	
		 		 	Print Name    BEVERLY J ECKERT                            
          	 	

  

 4 

 EXHIBIT A 
 FLOOR PLAN OF PREMISES 
 [diagram] 
 EXHIBIT A-1 
 FLOOR PLAN OF PREMISES 
 [diagram]Employment Offer Letter

 Exhibit 10.7 
 Thursday, September 15, 2005 
 Howard Foyt, M.D., Ph.D. 
 1205 Sierra Linda Drive 
 Escondido, CA 92025 
 Dear
Howard: 
 This is to confirm our offer to you to join Metabasis Therapeutics, Inc. as a Vice President in the Clinical Development department. The following
will be the basic terms of your employment with the Company: 
  

			
	Title:	  	Vice President, Clinical Development
		
	Start Date:	  	October 3, 2005
		
	Salary:	  	$230,000 per year payable bi-weekly, less standard deductions and withholdings

 Metabasis Therapeutics, Inc. offers a comprehensive benefits program including medical and dental insurance which
becomes effective the first day of the month following your date of hire. We also offer an employee contribution 401 (k) plan. You are eligible for vacation and holiday benefits per the provisions in the Company’s employee handbook.
Additionally, per your request, your annual vacation allotment will be as follows: 
  

			
	1 Year	  	16 days
		
	2 Years	  	17 days
		
	3 Years	  	18 days
		
	4 Years	  	19 days
		
	5-14 Years	  	20 days
		
	15+ Years	  	25 days

 Subject to the approval of the Board of Directors, you will be granted options to purchase 54,610 shares of
Metabasis Therapeutics, Inc. common stock, which will have an exercise price of the fair market value of the Company’s common stock on the date of the grant. The option will be granted pursuant to the terms of a separate stock option agreement
and the terms of the Metabasis Therapeutics, Inc. employee stock plan. 
 In addition to your base salary, you will be eligible to earn an annual
discretionary performance bonus (the “Bonus”). Your target Bonus will be up to 20% of your annual base salary, assuming 100% attainment of individual and company goals. You must be employed on the date the Bonus is awarded to earn any
portion of the Bonus. The determinations of the Company’s Board of Directors with respect to your Bonus will be final and binding. The Bonus program is subject to change or suspension at the discretion of the Company’s Board of Directors.

 You will also be eligible to receive a signing bonus under the following terms. If your start date 
 Howard Foyt, M.D., Ph.D. 
 September 15, 2005 
 Page 2 of 2 
 as an employee or consultant begins on or before
October 3, 2005, you will receive a signing bonus of $25,000, grossed up for federal and state taxes. If your start date as an employee or consultant begins on or before November 1, 2005, but later than October 3, 2005, you will
receive a signing bonus of $10,000, grossed up for federal and state taxes. However, should your start date go beyond November 1, 2005, we reserve the right to withdraw the offer. Please note that should you work with the Company on a
consulting basis, your consulting fee will not exceed the salary as stated in the terms of this letter. 
 You will be expected to execute and deliver an
Employee Proprietary Information and Inventions Agreement in consideration for your employment. This agreement is attached to this letter and is incorporated by reference herein. 
 In accordance with the Immigration Reform and Control Act of 1986, you will be required to provide documents which establish your identity and employment eligibility on your first day of employment. 
 We are excited about the opportunity which we have to build Metabasis Therapeutics, Inc. into an outstanding success. A key component to accomplishing this is to build a
strong team with bright, dynamic individuals. While we look forward to a long and mutually beneficial relationship, should you decide to accept our offer you will be an “at-will” employee of the Company. This means that either you or the
Company may terminate employment at any time. We sincerely hope that you will accept our offer to join the Metabasis Therapeutics team. 
 To formally record
your acceptance of our offer of employment, please sign below and return one original of this letter to me as soon as possible. 
 Sincerely, 
  

	
	
	/s/ MARK ERION
	Mark Erion, Ph.D.
	Executive Vice President, Research and Development

  

			
	Enclosures:	  	Employee Benefits Information
		  	Employee Proprietary Information and Inventions Agreement

  

					
			
	/s/ HOWARD FOYT	 		 	September 15, 2005
	Howard Foyt, M.D., Ph.D.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00156-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00156-of-00352.parquet"}]]