Document:

EX-10.3

 Exhibit 10.3 

FORM OF EXCHANGE AGREEMENT 

This EXCHANGE AGREEMENT (this “Agreement”), dated as of June 24, 2020, is entered into by and among La Jolla
Pharmaceutical Company, a California corporation (“Parent”), TTP Merger Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent (“Purchaser”), and the stockholder of Tetraphase Pharmaceuticals,
Inc. set forth on Schedule A hereto (the “Stockholder”). Capitalized terms used but not otherwise defined in this Agreement shall have the respective meanings ascribed to such terms in the Merger Agreement (as defined below).

 WHEREAS, as of the date hereof, the Stockholder is the record and beneficial owner (as defined in Rule
13d-3 under the Exchange Act) of the Company Warrants to purchase Company Common Stock set forth opposite the Stockholder’s name on Schedule A (all such Company Warrants, the “Subject
Warrants”); 
 WHEREAS, concurrently with the execution hereof, Parent, Purchaser and Tetraphase Pharmaceuticals, Inc., a Delaware
corporation (the “Company”), are entering into an Agreement and Plan of Merger, dated as of the date hereof (as it may be amended from time to time, the “Merger Agreement”), which provides, among other things, that
(i) Purchaser shall commence a tender offer (the “Offer”) to purchase all of the outstanding shares of Company Common Stock and (ii) following the completion of the Offer, Purchaser shall be merged with and into the
Company, with the Company surviving the Merger and becoming a wholly-owned subsidiary of Parent, in each case upon the terms and subject to the conditions set forth in the Merger Agreement; and 

WHEREAS, as a condition to their willingness to enter into the Merger Agreement, and as an inducement and in consideration for Parent and
Purchaser to enter into the Merger Agreement, the Stockholder has agreed to enter into this Agreement. 
 NOW, THEREFORE, in consideration
of the foregoing and the respective representations, warranties, covenants and agreements set forth below and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to
be legally bound, do hereby agree as follows: 
 ARTICLE I 

[INTENTIONALLY LEFT BLANK] 

ARTICLE II 

REPRESENTATIONS AND WARRANTIES OF THE STOCKHOLDERS 

The Stockholder represents and warrants to Parent and Purchaser that: 

2.1    Authorization; Binding Agreement. If the Stockholder is not an individual, the Stockholder is duly organized
and validly existing in good standing under the laws of the jurisdiction in which it is incorporated or constituted and the consummation of the transactions contemplated hereby are within the Stockholder’s entity powers and have been duly
authorized by all necessary entity actions on the part of the Stockholder, and the Stockholder has full power 

 
and authority to execute, deliver and perform this Agreement and to consummate the transactions contemplated hereby. If the Stockholder is an individual, the Stockholder has full legal capacity,
right and authority to execute and deliver this Agreement and to perform the Stockholder’s obligations hereunder. This Agreement has been duly and validly executed and delivered by the Stockholder and constitutes a valid and binding obligation
of the Stockholder enforceable against the Stockholder in accordance with its terms, subject to the effects of bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium and other similar Legal Requirements relating to or affecting
creditors’ rights generally and general equitable principles (whether considered in a proceeding in equity or at law). 

2.2    Non-Contravention. Neither the execution and delivery of this
Agreement by the Stockholder nor the consummation by the Stockholder of the transactions contemplated hereby nor compliance by the Stockholder with any provisions herein will (a) if the Stockholder is not an individual, contravene, conflict
with or result in a violation of any of the provisions of the certificate of incorporation, bylaws or other similar charter or organizational documents of the Stockholder, (b) require any consent, approval, authorization or permit of, or filing
with or notification to, any supranational, national, foreign, federal, state or local government or subdivision thereof, or governmental, judicial, legislative, executive, administrative or regulatory authority on the part of the Stockholder,
except for compliance with the applicable requirements of the Securities Act, the Exchange Act or any other United States or federal securities laws and the rules and regulations promulgated thereunder, (c) contravene, conflict with or result
in a violation or breach of, or result in a default under (or give rise to any right of termination, cancellation, modification or acceleration) under any of the terms, conditions or provisions of any note, license, agreement, contract, indenture or
other instrument or obligation to which the Stockholder is a party or by which the Stockholder or any of its assets may be bound, (d) result (or, with the giving of notice, the passage of time or otherwise, would result) in the creation or
imposition of any mortgage, lien, pledge, charge, security interest or encumbrance of any kind on any asset of the Stockholder (other than one created by Parent or Purchaser), or (e) violate any order, writ, injunction, decree, statute, rule or
regulation applicable to the Stockholder or by which any of its assets are bound, except as would not, in the case of each of clauses (b), (c), (d) and (e), reasonably be expected to have, individually or in the aggregate, a material adverse effect
on the Stockholder’s ability to perform its obligations under this Agreement. 
 2.3    Ownership of Subject
Warrants. The Stockholder is the record and beneficial owner (as defined in Rule 13d-3 under the Exchange Act) of all the Stockholder’s Subject Warrants and has good and marketable title to all such
Subject Warrants free and clear of any liens, claims, proxies, voting trusts or agreements, options, rights, understandings or arrangements or any other encumbrances or restrictions whatsoever on title, transfer or exercise of any rights of the
Stockholder in respect of such Subject Warrants (collectively, “Encumbrances”), except for any such Encumbrance that may be imposed pursuant to (i) this Agreement; (ii) any applicable restrictions on transfer under the
Securities Act or any other applicable securities law, (iii) any written policies of the Company with respect to the trading of securities in connection with insider trading restrictions, applicable securities laws and similar considerations;
(iv) any lien for current Taxes not yet due and payable or Taxes being contested in good faith by appropriate proceedings; and (v) liens that do not (in any individual case or in the aggregate) restrict in any material respect the ability
of the Stockholder to comply with its obligations under this Agreement. 

  
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 2.4    Intentionally Left Blank. 

2.5    Reliance. The Stockholder understands and acknowledges that Parent and Purchaser are entering into the
Merger Agreement in reliance upon the Stockholder’s execution, delivery and performance of this Agreement. 

2.6    Absence of Litigation. With respect to the Stockholder, as of the date hereof, there is no Legal Proceeding
pending against, or, to the actual knowledge of the Stockholder, threatened in writing against the Stockholder or any of the Stockholder’s properties or assets (including any Shares beneficially owned by the Stockholder) before or by any
Governmental Body that would reasonably be expected to prevent or otherwise materially impair the ability of the Stockholder to perform the obligations of the Stockholder under this Agreement. 

ARTICLE III 

REPRESENTATIONS AND WARRANTIES OF PARENT AND PURCHASER 

Parent and Purchaser represent and warrant to the Stockholder that: 

3.1    Organization and Qualification. Each of Parent and Purchaser is a duly organized and validly existing
corporation in good standing under the laws of the jurisdiction of its organization. 
 3.2    Authority for this
Agreement. Each of Parent and Purchaser has all requisite entity power and authority to execute, deliver and perform its obligations under this Agreement and to consummate the transactions contemplated hereby. The execution and delivery of this
Agreement by Parent and Purchaser have been duly and validly authorized by all necessary entity action on the part of each of Parent and Purchaser, and no other entity proceedings on the part of Parent and Purchaser are necessary to authorize this
Agreement. This Agreement has been duly and validly executed and delivered by Parent and Purchaser and, assuming the due authorization, execution and delivery by the Stockholder, constitutes legal, valid and binding obligation of each of Parent and
Purchaser, enforceable against each of Parent and Purchaser in accordance with its terms, subject to the effects of bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium and other similar Legal Requirements relating to or
affecting creditors’ rights generally and general equitable principles (whether considered in a proceeding in equity or at law). 

ARTICLE IV 
 ADDITIONAL
COVENANTS OF THE STOCKHOLDER 
 The Stockholder hereby covenants and agrees that until the termination of this Agreement: 

4.1    Intentionally Omitted. 

4.2    Documentation and Information. From the date of this Agreement until the Closing, the Stockholder shall not
make any public announcement regarding this Agreement, the Contemplated Transactions and the other transactions contemplated hereby without the prior written consent of Parent, except (a) as may be required by applicable Legal Requirements

  
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(provided that reasonable notice of any such disclosure will be provided to Parent) or (b) to the extent such announcement contains information that has been previously disclosed publicly.
The Stockholder consents to and hereby authorizes Parent and Purchaser to publish and disclose in all documents and schedules filed with the SEC, and any press release or other disclosure document necessary in connection with the Offer, the Merger
and the other Contemplated Transactions, the existence of this Agreement and the nature of the Stockholder’s commitments and obligations under this Agreement, and the Stockholder acknowledges that Parent and Purchaser may, in Parent’s sole
discretion, file this Agreement or a form hereof with the SEC or any other Governmental Body. The Stockholder agrees to promptly give Parent and the Company any information either may reasonably require for the preparation of any such disclosure
documents, and the Stockholder agrees to promptly notify Parent and the Company upon becoming aware of any required corrections with respect to any written information supplied by the Stockholder specifically for use in any such disclosure document,
if and to the extent that any such information shall have become false or misleading in any material respect. 

4.3    Adjustments. In the event of any stock split, stock dividend, merger, reorganization, recapitalization,
reclassification, combination, exchange of shares or the like of the capital stock of the Company affecting the Subject Warrants, the terms of this Agreement shall apply to the resulting securities. 

4.4    Waiver of Certain Actions. The Stockholder hereby agrees not to commence or participate in, and to take all
actions necessary to opt out of any class in any class action with respect to, any claim, derivative or otherwise, against Parent, Purchaser or any of their respective successors (a) challenging the validity of, or seeking to enjoin or delay
the operation of, any provision of this Agreement or the Merger Agreement (including any claim seeking to enjoin or delay the Offer or the Closing) or (b) alleging a breach of any duty of the Company Board in connection with the Merger
Agreement, this Agreement or the transactions contemplated thereby or hereby. 
 4.5    No Solicitation. Subject
to Section 4.4 (No Solicitation) of the Merger Agreement, the Stockholder agrees that the Stockholder shall immediately cease any solicitation, discussions or negotiations with any Persons that may be ongoing by the Stockholder as of the date
of this Agreement with respect to an Acquisition Proposal. Until the Specified Time, the Stockholder shall not, directly or indirectly, (a) solicit, initiate or knowingly facilitate or knowingly encourage any inquiries or the making of any
proposal or offer that constitutes, or would reasonably be expected to lead to, an Acquisition Proposal or (b) engage in, continue or otherwise participate in any discussions or negotiations regarding, or furnish to any other Person any non-public information in connection with an Acquisition Proposal or any proposal or offer that would reasonably be expected to lead to an Acquisition Proposal. 

ARTICLE V 
 WARRANT
TREATMENT 
 The Stockholder acknowledges and agrees that, at the Effective Time, each Subject Warrant owned by the Stockholder that is
then-outstanding and unexercised as of immediately prior to the Effective Time shall, pursuant to the terms hereof and as a result of the Merger and without any other action on the part of the Stockholder, receive, in lieu of any other amount or

  
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consideration to which the Stockholder might otherwise have been entitled to receive pursuant to such Subject Warrant, $2.69 in cash for each share of Company Common Stock for which such January
Warrant (as set forth on Schedule A) was exercisable immediately prior to the Effective Time (subject to adjustment in the event of a stock split, division or subdivision, stock dividend, reverse stock split, consolidation, reclassification,
recapitalization or other similar transaction affecting the Company Common Stock), subject to Section 1.12 of the Merger Agreement. 

ARTICLE VI 

MISCELLANEOUS 

6.1    Notices. All notices, requests, demands and other communications under this Agreement shall be in writing
and shall be deemed to have been duly given or made as follows: (a) if sent by registered or certified mail in the United States return receipt requested, upon receipt; (b) if sent designated for overnight delivery by nationally recognized
overnight air courier (such as Federal Express), one business day after mailing; (c) if sent by facsimile transmission or e-mail before 5:00 p.m. Eastern Time, when transmitted and receipt is confirmed;
(d) if sent by facsimile transmission or e-mail after 5:00 p.m. Eastern Time and receipt is confirmed, on the following business day; and (e) if otherwise actually personally delivered, when
delivered; provided, that the notice or other communication is sent to the address, facsimile number or email address set forth (i) in the case to Parent or Purchaser, to the address or e-mail
address set forth in Section 9.9 of the Merger Agreement and (ii) if to the Stockholder, to the Stockholder’s address, facsimile number or e-mail address set forth on a signature page hereto, or
to such other address, facsimile number or e-mail address as such party may hereafter specify for the purpose by notice to each other party hereto. 

6.2    Termination. This Agreement shall terminate automatically with respect to the Stockholder, without any
notice or other action by any Person, upon the first to occur of (a) the termination of the Merger Agreement in accordance with its terms, (b) the Effective Time, (c) any amendment to the Merger Agreement that reduces the amount, or
changes the form, of consideration payable to the Stockholder in the Contemplated Transactions, imposes additional restrictions on the Stockholder or otherwise materially and adversely impacts the Stockholder, (d) a Company Adverse Change in
Recommendation or (e) the mutual written consent of Parent and the Stockholder. Upon termination of this Agreement, no party shall have any further obligations or liabilities under this Agreement; provided, however, that
(x) nothing set forth in this Section 6.2 shall relieve any party from liability for any Willful Breach of this Agreement prior to termination hereof and (y) the provisions of this Article VI shall survive
any termination of this Agreement. 
 6.3    Amendments and Waivers. 

(a)    Any provision of this Agreement may be amended or waived if such amendment or waiver is in writing and is signed,
in the case of an amendment, by each party to this Agreement or, in the case of a waiver, by each party against whom the waiver is to be effective. 

(b)    No failure on the part of any party to exercise any power, right, privilege or remedy under this Agreement, and no
delay on the part of any party in exercising any power, 

  
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right, privilege or remedy under this Agreement, shall operate as a waiver of such power, right, privilege or remedy; and no single or partial exercise of any such power, right, privilege or
remedy shall preclude any other or further exercise thereof or of any other power, right, privilege or remedy. 

6.4    Expenses. All fees and expenses incurred in connection herewith and the transactions contemplated hereby
shall be paid by the party incurring such fees and expenses, whether or not the Offer and the Merger are consummated. 

6.5    Entire Agreement; Assignment. This Agreement, together with Schedule A, and the other documents and
certificates delivered pursuant hereto, constitute the entire agreement, and supersede all prior agreements and understandings, both written and oral, among the parties with respect to the subject matter of this Agreement. Neither this Agreement nor
any party’s rights or obligations hereunder may be assigned or delegated by such party without the prior written consent of the other parties, and any attempted assignment or delegation of this Agreement or any of such rights or obligations by
any party without the prior written consent of the other parties shall be void and of no effect; provided, that Parent or Purchaser may assign any of their respective rights and obligations to any direct or indirect Subsidiary of Parent, but
no such assignment shall relieve Parent or Purchaser, as the case may be, of its obligations hereunder. 

6.6    Enforcement of the Agreement. The parties agree that irreparable damage would occur in the event that the
Stockholder did not perform any of the provisions of this Agreement in accordance with their specific terms or otherwise breached any such provisions. It is accordingly agreed that Parent and Purchaser shall be entitled to an injunction or
injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement in addition to any other remedy to which they are entitled at law or in equity. Any and all remedies herein expressly conferred
upon Parent and Purchaser will be deemed cumulative with and not exclusive of any other remedy conferred hereby, or by law or equity upon Parent or Purchaser, and the exercise by Parent or Purchaser of any one remedy will not preclude the exercise
of any other remedy. 
 6.7    Jurisdiction; Waiver of Jury Trial. 

(a)    This Agreement shall be governed by, and construed in accordance with, the laws of the State of Delaware, without
giving effect to any laws, rules or provisions that would cause the application of the laws of any jurisdiction other than the State of Delaware. In any action between any of the parties arising out of or relating to this Agreement or the
transactions contemplated hereby, each of the parties irrevocably and unconditionally consents and submits to the exclusive jurisdiction and venue of the Chancery Court of the State of Delaware. The parties agree that irreparable damage would occur
and that the parties would not have any adequate remedy at law in the event that any of the provisions of this Agreement were not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that the parties
shall be entitled to an injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and provisions of this Agreement, this being in addition to any other remedy to which they are entitled at law or in
equity. All rights and remedies existing under this Agreement are cumulative to, and not 

  
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exclusive of, any rights or remedies otherwise available. The Stockholder hereby agrees that service of any process, summons, notice or document by U.S. registered mail in accordance with
Section 6.1 shall be effective service of process for any proceeding arising out of, relating to or in connection with this Agreement or the transactions contemplated hereby. 

(b)    THE STOCKHOLDER ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE UNDER THIS AGREEMENT IS LIKELY TO
INVOLVE COMPLICATED AND DIFFICULT ISSUES, AND THEREFORE EACH SUCH PARTY HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY RIGHT SUCH PARTY MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION ARISING OUT OF, RELATING TO OR IN CONNECTION WITH THIS
AGREEMENT. THE STOCKHOLDER CERTIFIES AND ACKNOWLEDGES THAT (I) NO REPRESENTATIVE, AGENT OR ATTORNEY OF PARENT OR PURCHASER HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT PARENT OR PURCHASER WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE
THE FOREGOING WAIVER, (II) THE STOCKHOLDER UNDERSTANDS AND HAS CONSIDERED THE IMPLICATION OF THIS WAIVER, (III) THE STOCKHOLDER MAKES THIS WAIVER VOLUNTARILY, AND (IV) THE STOCKHOLDER HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY,
AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION. 
 6.8    Descriptive Headings. The
descriptive headings herein are inserted for convenience of reference only and are not intended to be part of or to affect the meaning or interpretation of this Agreement. 

6.9    Parties in Interest. This Agreement shall be binding upon and inure solely to the benefit of each party
hereto, and nothing in this Agreement, express or implied, is intended to confer upon any other Person any rights or remedies of any nature whatsoever under or by reason of this Agreement. 

6.10    Severability. Any term or provision of this Agreement that is invalid or unenforceable in any situation in
any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions of this Agreement or the validity or enforceability of the offending term or provision in any other situation or in any other jurisdiction. If a
final judgment of a court of competent jurisdiction declares that any term or provision of this Agreement is invalid or unenforceable, the parties hereto agree that the court making such determination shall have the power to limit such term or
provision, to delete specific words or phrases or to replace such term or provision with a term or provision that is valid and enforceable and that comes closest to expressing the intention of the invalid or unenforceable term or provision, and this
Agreement shall be valid and enforceable as so modified. In the event such court does not exercise the power granted to it in the prior sentence, the parties hereto agree to replace such invalid or unenforceable term or provision with a valid and
enforceable term or provision that will achieve, to the extent possible, the economic, business and other purposes of such invalid or unenforceable term or provision. 

6.11    Counterparts. This Agreement may be executed in counterparts, each of which shall be deemed to be an
original, but all of which, taken together, shall constitute one and the 

  
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same agreement. This Agreement or any counterpart may be executed and delivered by facsimile copies or delivered by electronic communications by portable document format (.pdf), each of which
shall be deemed an original. 
 6.12    Construction. 

(a)    For purposes of this Agreement, whenever the context requires: the singular number shall include the plural, and
vice versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include masculine and feminine genders. 

(b)    The parties hereto agree that any rule of construction to the effect that ambiguities are to be resolved against
the drafting party shall not be applied in the construction or interpretation of this Agreement. 
 (c)    As used in
this Agreement, the words “include” and “including,” and variations thereof, shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words “without limitation.” 

(d)    Except as otherwise indicated, all references in this Agreement to “Sections” and
“Schedules” are intended to refer to Sections of this Agreement and Schedules to this Agreement. 

(e)    The bold-faced headings contained in this Agreement are for convenience of reference only, shall not be deemed to
be a part of this Agreement and shall not be referred to in connection with the construction or interpretation of this Agreement. 

6.13    Further Assurances. The Stockholder will execute and deliver, or cause to be executed and delivered, all
further documents and instruments and use its reasonable best efforts to take, or cause to be taken, all actions and to do, or cause to be done, all things necessary, proper or advisable under applicable Legal Requirements, to perform its
obligations under this Agreement. 
 6.14    No Agreement Until Executed. This Agreement shall not be effective
unless and until (a) the Merger Agreement is executed by all parties thereto and (b) this Agreement is executed by all parties hereto. 

6.15    Capacity as Stockholder. The Stockholder signs this Agreement solely in the Stockholder’s capacity as
a stockholder and warrantholder of the Company, and not in the Stockholder’s capacity as a director, officer or employee of the Company. Notwithstanding anything herein to the contrary, nothing herein shall in any way restrict a director or
officer of the Company (including any director or officer who is an Affiliate of the Stockholder) in the taking of any actions (or failure to act) in his or her capacity as a director or officer of the Company, or in the exercise of his or her
fiduciary duties as a director or officer of the Company, or prevent or be construed to create any obligation on the part of any director or officer of the Company from taking any action in his or her capacity as such director or officer, and no
action taken in any such capacity as an officer or director of the Company shall be deemed to constitute a breach of this Agreement. 

  
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 [Signature Pages Follow] 

  
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 The parties are executing this Agreement on the date set forth in the introductory clause.

  

	
	PARENT
	
	LA JOLLA PHARMACEUTICAL COMPANY
	
	By:                                     
                                         
   
	Name:
	Title:
	
	PURCHASER
	
	TTP MERGER SUB, INC.
	
	By:                                     
                                         
   
	Name:
	Title:

 [Signature Page to Exchange Agreement] 

 
	
	STOCKHOLDER
	
	[STOCKHOLDER]
	
	By:                                     
                                         
   
	      Name:
	      Title:
	
	Address: [●]

 [Signature Page to Exchange Agreement] 

 Schedule A 

 

							
	 Stockholder
	 	 January
Warrants
	 	 Date of
Issuance of
Subject
Warrants
	  	 Number
of
Shares
Underlying
Subject
WarrantsEX-4.3

 Exhibit 4.3 
  

 
  

BARCLAYS PLC, 
 Issuer, 

THE BANK OF NEW YORK MELLON, LONDON BRANCH, 

as Trustee 
 and 

THE BANK OF NEW YORK MELLON SA/NV, LUXEMBOURG BRANCH 

as Senior Debt Security Registrar 
  

 
 SEVENTH SUPPLEMENTAL INDENTURE 

Dated as of June 24, 2020 
  

 
 To the Senior Debt Securities
Indenture, dated as of January 17, 2018, 
 Between Barclays PLC 

and 
 The Bank of New York Mellon,
London Branch, as Trustee 
  
  

 
 $1,000,000,000 Principal Amount of
2.645% Fixed Rate Resetting Senior Callable Notes due 2031 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	ARTICLE I	 
	
	DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION	  

			
	 SECTION 1.01
	 	Definitions	  	 	1	 
			
	 SECTION 1.02
	 	Effect of Headings	  	 	5	 
			
	 SECTION 1.03
	 	Separability Clause	  	 	5	 
			
	 SECTION 1.04
	 	Benefits of Instrument	  	 	5	 
			
	 SECTION 1.05
	 	Relation to Base Indenture	  	 	5	 
			
	 SECTION 1.06
	 	Construction and Interpretation	  	 	5	 
	
	ARTICLE II	  

	
	2.645% FIXED RATE RESETTING SENIOR CALLABLE NOTES DUE 2031	  

			
	 SECTION 2.01
	 	Creation of Series; Establishment of Form	  	 	6	 
			
	 SECTION 2.02
	 	Interest	  	 	6	 
			
	 SECTION 2.03
	 	Payment of Principal, Interest and Other Amounts	  	 	7	 
			
	 SECTION 2.04
	 	Optional Redemption	  	 	7	 
			
	 SECTION 2.05
	 	Loss Absorption Disqualification Event Redemption	  	 	9	 
			
	 SECTION 2.06
	 	Events of Default	  	 	9	 
			
	 SECTION 2.07
	 	Enforcement Events and Remedies	  	 	9	 
			
	 SECTION 2.08
	 	Trustee’s Duties	  	 	10	 
			
	 SECTION 2.09
	 	Waiver of Certain Past Events of Default.	  	 	10	 
			
	 SECTION 2.10
	 	Notice of Defaults Following an Event of Default	  	 	11	 
			
	 SECTION 2.11
	 	Applicability of the Term “Event of Default.”	  	 	11	 
			
	 SECTION 2.12
	 	Certain Acts of Holders Following an Event of Default.	  	 	11	 
			
	 SECTION 2.13
	 	Notice of Redemption	  	 	11	 
			
	 SECTION 2.14
	 	Acknowledgement with respect to Treatment of EEA BRRD Liabilities	  	 	12	 
			
	 SECTION 2.15
	 	Acknowledgement with Respect to Treatment of BRRD Liabilities	  	 	13	 
	
	ARTICLE III	  

	
	MISCELLANEOUS PROVISIONS	  

	 SECTION 3.01
	 	Effectiveness	  	 	13	 
			
	 SECTION 3.02
	 	Original Issue	  	 	13	 
			
	 SECTION 3.03
	 	Ratification and Integral Part	  	 	13	 
			
	 SECTION 3.04
	 	Priority	  	 	14	 
			
	 SECTION 3.05
	 	Not Responsible for Recitals or Issuance of Securities	  	 	14	 

  
 -i- 

							
	 SECTION 3.06
	 	Successors and Assigns	  	 	14	 
			
	 SECTION 3.07
	 	Counterparts	  	 	14	 
			
	 SECTION 3.08
	 	Governing Law	  	 	14	 
		
	 ANNEX I – Interest Terms of the Securities
	  	 	I-1	 
		
	 EXHIBIT A – Form of Global Security
	  	 	A-1	 

  
 -ii- 

 SEVENTH SUPPLEMENTAL INDENTURE, dated as of June 24, 2020 (the “Seventh
Supplemental Indenture”), among BARCLAYS PLC, a public limited company registered in England and Wales (herein called the “Company”), having its registered office at 1 Churchill Place, London E14 5HP, United Kingdom, THE
BANK OF NEW YORK MELLON, LONDON BRANCH, a New York banking corporation, as Trustee and Paying Agent (herein called the “Trustee”), having a Corporate Trust Office at One Canada Square, London E14 5AL, United Kingdom, and THE BANK OF
NEW YORK MELLON SA/NV, LUXEMBOURG BRANCH, as Senior Debt Security Registrar, having an office at 2-4 Rue Eugene Ruppert, Vertigo Building – Polaris, Luxembourg, 2453, Luxembourg, to the SENIOR DEBT
SECURITIES INDENTURE, dated as of January 17, 2018, between the Company and the Trustee (as heretofore amended and supplemented, the “Base Indenture” and, together with this Seventh Supplemental Indenture, the
“Indenture”). 
 RECITALS OF THE COMPANY 

WHEREAS, the Company and the Trustee are parties to the Base Indenture, which provides for the issuance by the Company from time to time of
its Senior Debt Securities in one or more series; 
 WHEREAS, Section 9.01 of the Base Indenture permits supplements thereto without
the consent of Holders of Senior Debt Securities to establish the form or terms of Senior Debt Securities of any series as permitted by Sections 2.01 and 3.01 of the Base Indenture; 

WHEREAS, as contemplated by Section 3.01 of the Base Indenture, the Company intends to issue an additional series of Senior Debt
Securities, to be known as the Company’s “2.645% Fixed Rate Resetting Senior Callable Notes due 2031” (the “Securities”) under the Indenture; 

WHEREAS, the Company and the Trustee desire to amend the Base Indenture to change certain execution formalities with respect to Senior Debt
Securities issued on or after the date hereof; 
 WHEREAS, the Company has taken all necessary corporate action to authorize the execution
and delivery of this Seventh Supplemental Indenture; 
 NOW, THEREFORE, THIS SEVENTH SUPPLEMENTAL INDENTURE WITNESSETH: 

For and in consideration of the premises and the other good and valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the Company and the Trustee mutually agree as follows with regard to the Securities: 
 ARTICLE I 

DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 

SECTION 1.01 Definitions. Except as otherwise expressly provided or unless the context otherwise requires, all terms used in this
Seventh Supplemental Indenture that are defined in the Base Indenture shall have the meanings ascribed to them in the Base Indenture. 
 The
following terms used in this Seventh Supplemental Indenture have the following respective meanings with respect to the Securities only: 

“Bail-in Legislation” has the meaning set forth in Section 2.14 hereof.

  
 -1- 

 “Base Indenture” has the meaning set forth in the first paragraph of this
Seventh Supplemental Indenture. 
 “BRRD” has the meaning set forth in Section 2.14 hereof. 

“BRRD Party” has the meaning set forth in Section 2.14 hereof. 

“Business Day” means any weekday, other than one on which banking institutions are authorized or obligated by law, regulation
or executive order to close in London, England or in New York City, United States. 
 “Calculation Agent” has the meaning
set forth in Annex I hereto. 
 “Capital Regulations” means, at any time, the laws, regulations, requirements, standards,
guidelines and policies relating to capital adequacy and/or minimum requirement for own funds and eligible liabilities and/or loss absorbing capacity for credit institutions of either (i) the PRA and/or (ii) any other national or European
authority, in each case then in effect in the United Kingdom (or in such other jurisdiction in which the Company may be organized or domiciled) and applicable to the Group including, as at the date hereof, CRD and related technical standards. 

“Capital Requirements Directive” means Directive 2013/36/EU on access to the activity of credit institutions and the
prudential supervision of credit institutions and investment firms, as amended or replaced from time to time (including as amended by Directive (EU) 2019/878 of the European Parliament and of the Council of May 20, 2019) or similar laws in the
United Kingdom. 
 “Company” has the meaning set forth in the first paragraph of this Seventh Supplemental Indenture, and
includes any successor entity. 
 “Comparable Treasury Issue” has the meaning set forth in Annex I hereto. 

“Comparable Treasury Price” has the meaning set forth in Annex I hereto. 

“CRD” means the legislative package consisting of the Capital Requirements Directive and the CRD Regulation. 

“CRD Regulation” means Regulation (EU) No. 575/2013 on prudential requirements for credit institutions and investment
firms of the European Parliament and of the Council of June 26, 2013, as amended or replaced from time to time (including as amended by Regulation (EU) 2019/876 of the European Parliament and of the Council of May 20, 2019, to the extent
then in application) or similar laws in the United Kingdom. 
 “Determination Agent” has the meaning set forth in
Section 2.04 hereof. 
 “DTC” means The Depository Trust Company, or any successor clearing system. 

“EEA Bail-in Power” has the meaning set forth in Section 2.14 hereof.

 “EEA BRRD Liability” has the meaning set forth in Section 2.14 hereof. 

  
 -2- 

 “EU Bail-in Legislation
Schedule” has the meaning set forth in Section 2.14 hereof. 
 “Group” means the Company (or any successor
entity) and its consolidated subsidiaries. 
 “Indenture” has the meaning set forth in the first paragraph of this Seventh
Supplemental Indenture. 
 “Initial Interest Rate” has the meaning set forth in Annex I hereto. 

“Interest Payment Date” has the meaning set forth in Annex I hereto. 

“Issue Date” has the meaning set forth in Section 2.01(f) hereof. 

“Loss Absorption Disqualification Event” with respect to a series of securities means the whole or any part of the principal
amount of the Securities Outstanding of such series at any time being excluded from or ceasing to count towards the Company’s and/or the Group’s own funds and eligible liabilities and/or loss absorbing capacity, in each case for the
purposes of, and in accordance with, the relevant Capital Regulations, provided that a Loss Absorption Disqualification Event shall not occur if such whole or part of the principal amount of the Securities Outstanding of such series is excluded
from, or ceases to count towards, such own funds and eligible liabilities and/or loss absorbing capacity due to the remaining maturity of the Securities of such series being less than the period prescribed by the relevant Capital Regulations. 

“Loss Absorption Regulations Event” means that (i) any Capital Regulations become effective with respect to the Company
and/or the Group or (ii) there is an amendment to, or change in, any Capital Regulation, or any change in the official application of any Capital Regulation that becomes effective with respect to the Company and/or the Group. 

“Make-Whole Redemption” has the meaning set forth in Section 2.04 hereof.

 “Margin” has the meaning set forth in Annex I hereto. 

“Monetary Judgment” has the meaning set forth in Section 2.07(c) hereof. 

“Non-Payment Event” has the meaning set forth in Section 2.07(b) hereof.

 “Optional Redemption Comparable Treasury Issue” has the meaning set forth in Section 2.04 hereof. 

“Optional Redemption Comparable Treasury Price” has the meaning set forth in Section 2.04 hereof. 

“Optional Redemption Reference Treasury Dealer” has the meaning set forth in Section 2.04 hereof. 

“Optional Redemption Reference Treasury Dealer Quotations” has the meaning set forth in Section 2.04 hereof. 

  
 -3- 

 “Optional Redemption Treasury Rate” has the meaning set forth in
Section 2.04 hereof. 
 “Par Redemption” has the meaning set forth in Section 2.04 hereof. 

“Par Redemption Date” has the meaning set forth in Annex I hereto. 

“Performance Obligation” has the meaning set forth in Section 2.07(c) hereof. 

“Reference Treasury Dealer” has the meaning set forth in Annex I hereto. 

“Reference Treasury Dealer Quotations” has the meaning set forth in Annex I hereto. 

“Regular Record Date” means the close of business on the Business Day immediately preceding each Interest Payment Date (or,
if the Securities are held in definitive form, the close of business on the 15th Business Day preceding each Interest Payment Date). 

“Relevant EEA Resolution Authority” has the meaning set forth in Section 2.14 hereof. 

“Reset Date” has the meaning set forth in Annex I hereto. 

“Reset Period” has the meaning set forth in Annex I hereto. 

“Reset Determination Date” has the meaning set forth in Annex I hereto. 

“Securities” has the meaning set forth in the Recitals to this Seventh Supplemental Indenture. 

“Senior Enforcement Event” has the meaning set forth in Section 2.08 hereof. 

“Seventh Supplemental Indenture” has the meaning set forth in the first paragraph of this Seventh Supplemental Indenture.

 “Stated Maturity” has the meaning set forth in Section 2.01(g) hereof. 

“Subsequent Interest Rate” has the meaning set forth in Annex I hereto. 

“Trustee” has the meaning set forth in the first paragraph of this Seventh Supplemental Indenture, and includes any successor
entity. 
 “U.S. Treasury Rate” has the meaning set forth in Annex I hereto. 

A “Winding-Up Event” with respect to the Securities shall result if (i) a
court of competent jurisdiction in England (or such other jurisdiction in which the Company may be organized) makes an order for the Company’s winding-up which is not successfully appealed within thirty
(30) days of the making of such order, (ii) the Company’s shareholders adopt an effective resolution for the Company’s winding-up (other than, in the case of either (i) or (ii) above,
under or in connection with a scheme of reconstruction, merger or amalgamation not involving a bankruptcy or insolvency) or (iii) following the appointment of an administrator of the Company, the administrator gives notice that it intends to
declare and distribute a dividend. 

  
 -4- 

 SECTION 1.02 Effect of Headings. The Article and Section headings herein are for
convenience only and shall not affect the construction hereof. 
 SECTION 1.03 Separability Clause. In case any
provision in this Seventh Supplemental Indenture shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

SECTION 1.04 Benefits of Instrument. Nothing in this Seventh Supplemental Indenture, express or implied, shall give to any Person,
other than the parties hereto and their successors hereunder and the Holders, any benefit or any legal or equitable right, remedy or claim under the Indenture. 

SECTION 1.05 Relation to Base Indenture. This Seventh Supplemental Indenture constitutes an integral part of the Indenture.
Notwithstanding any other provisions of this Seventh Supplemental Indenture, all provisions of this Seventh Supplemental Indenture are expressly and solely for the benefit of the Holders of the Securities and the Trustee and any such provisions
shall not be deemed to apply to any other Senior Debt Securities issued under the Base Indenture and shall not be deemed to amend, modify or supplement the Base Indenture for any purpose other than with respect to the Securities. 

SECTION 1.06 Construction and Interpretation. Unless the context otherwise requires: 

(a) the words “hereof”, “herein” and “hereunder” and words of similar import, when used in this Seventh
Supplemental Indenture, refer to this Seventh Supplemental Indenture as a whole and not to any particular provision of this Seventh Supplemental Indenture; 

(b) the terms defined in the singular have a comparable meaning when used in the plural, and vice versa; 

(c) the terms “U.S. dollars,” “US$” and “$” refer to the lawful currency for the time being of the United States;

 (d) references herein to a specific Section, Article or Exhibit refer to Sections or Articles of, or an Exhibit to, this Seventh
Supplemental Indenture; 
 (e) wherever the words “include”, “includes” or “including” are used in this Seventh
Supplemental Indenture, they shall be deemed to be followed by the words “without limitation;” 
 (f) references to a Person are
also to its successors and permitted assigns; and 
 (g) the use of “or” is not intended to be exclusive unless expressly indicated
otherwise. 

  
 -5- 

 ARTICLE II 

2.645% FIXED RATE RESETTING SENIOR CALLABLE NOTES DUE 2031 

SECTION 2.01 Creation of Series; Establishment of Form. 

(a) There is hereby established an additional series of Senior Debt Securities under the Base Indenture entitled the “2.645% Fixed Rate
Resetting Senior Callable Notes due 2031.” 
 (b) The Securities shall be issued initially in the form of one or more registered
Global Securities that shall be deposited with DTC on the Issue Date. The Global Securities shall be registered in the name of Cede & Co. and executed and issued in substantially the form attached hereto as Exhibit A. 

(c) The Company shall issue the Securities in an aggregate principal amount of $1,000,000,000. The Company may from time to time, without the
consent of the Holders of the Securities, issue additional securities of such series having the same ranking and same interest rate, Stated Maturity, redemption terms and other terms as the Securities described in this Seventh Supplemental
Indenture, except for the price to the public and Issue Date. Any such additional securities subsequently issued shall rank equally and ratably with the Securities in all respects, so that such further securities shall be consolidated and form a
single series with the applicable series of the Securities. 
 (d) Any proposed transfer of an interest in Securities held in the form of a
Global Security shall be effected through the book-entry system maintained by DTC. 
 (e) The
Securities shall not have a sinking fund. 
 (f) The Securities shall be issued on June 24, 2020 (the “Issue Date”).

 (g) The stated maturity of the principal of the Securities shall be June 24, 2031 (the “Stated Maturity”). 

(h) The Securities shall be redeemable prior to their Stated Maturity in accordance with Section 2.04 hereof. 

(i) The Securities shall be issued in minimum denominations of $200,000 in principal amount and integral multiples of $1,000 in excess thereof.

 (j) Section 11.09 of the Base Indenture shall apply to the Securities. 

(k) The Securities shall constitute the Company’s direct, unconditional, unsecured and unsubordinated obligations and shall at all times
rank pari passu without any preference among themselves. In the event of a winding-up or administration of the Company, the Securities shall rank pari passu with all other outstanding unsecured and
unsubordinated obligations of the Company, present and future, except such obligations as are preferred by operation of law. 
 SECTION
2.02 Interest. 
 (a) The interest rate on the Securities shall be, or shall be determined, as set forth in Annex I hereto. 

(b) The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date shall, as provided in the Indenture, be
paid to the Person in whose name the relevant Security (or any Predecessor Senior Debt Security) is registered at the close of business on the Regular Record Date for such interest. 

  
 -6- 

 SECTION 2.03 Payment of Principal, Interest and Other Amounts. 

(a) Payments of principal of and interest on the Securities shall be made in such coin or currency of the United States of America as at the
time of payment is legal tender for payment of public and private debts and such payments on Securities represented by a Global Security shall be made through one or more Paying Agents appointed under the Base Indenture to DTC or its nominee, as the
Holder or Holders of the Global Security. Initially, the Paying Agent for the Securities shall be The Bank of New York Mellon, London Branch, One Canada Square, London E14 5AL, United Kingdom and the Place of Payment in respect of the Securities
shall be the Corporate Trust Office of the Trustee, which as of the date hereof is hereby designated for purposes of the Securities initially as the office or agency of the Trustee located at said address. Initially, the Senior Debt Security
Registrar for the Securities shall be The Bank of New York Mellon SA/NV, Luxembourg Branch, 2-4 Rue Eugene Ruppert, Vertigo Building – Polaris, Luxembourg, 2453, Luxembourg (which location shall also be a
Place of Payment for purposes of Section 3.05(a) of the Base Indenture). The Company at any time and from time to time may change the Paying Agent or, subject to Section 9.01 of the Base Indenture, the Place of Payment, and the Senior Debt
Security Registrar without prior notice to the Holders of the Securities, and in such an event the Company may act as Paying Agent or Senior Debt Security Registrar. Payments of principal of and interest on the Securities represented by a Global
Security shall be made by wire transfer of immediately available funds; provided, however, that in the case of payments of principal, such Global Security is first surrendered to the Paying Agent. If a date of redemption or repayment
or the Stated Maturity is not a Business Day, the Company may pay interest and principal and/or any amount payable upon redemption or repayment of the Securities on the next succeeding Business Day, but interest on that payment will not accrue
during the period from and after the date of redemption or repayment or such Stated Maturity. 
 SECTION 2.04 Optional Redemption.
Subject to the notice period and provisions set forth in Sections 11.02 and 11.04 of the Base Indenture, and to the conditions set forth in Section 11.10 of the Base Indenture, the Company may redeem, at its option (A) the Securities at
any time outstanding, in whole or in part, at any time on or after December 24, 2020 (six months following the Issue Date and, if any additional Securities are issued after the Issue Date, except for the period of six months beginning on the
issue date for any additional Securities) to (but excluding) the Par Redemption Date, at an amount equal to the higher of (i) 100% of the principal amount of the Securities to be redeemed and (ii) as determined by the Determination Agent, the
sum of the present values of the principal (discounted from the Par Redemption Date) and remaining payments of interest to be made on any scheduled Interest Payment Date to the Par Redemption Date for the Securities to be redeemed (not including
accrued but unpaid interest, if any, on the principal amount of the Securities) discounted to the Redemption Date on a semi-annual basis (assuming a 360-day year
consisting of twelve 30-day months) at the Optional Redemption Treasury Rate plus 30 basis points together with, in either case of (i) or (ii) above, accrued but unpaid interest, if any, on the principal
amount of the Securities to be redeemed to (but excluding) the Redemption Date (the “Make-Whole Redemption”) and/or (B) the Securities then outstanding, in whole but not in part,
on the Par Redemption Date, at an amount equal to 100% of their principal amount together with accrued but unpaid interest, if any, on the principal amount of the Securities to be redeemed to (but excluding) the Redemption Date (the “Par
Redemption”). 

  
 -7- 

 “Optional Redemption Treasury Rate” means, with respect to any
Redemption Date, the rate per annum equal to: (1) the yield, under the heading which represents the average for the week immediately prior to the calculation date, appearing in the most recently published statistical release designated
“H.15,” or any successor publication that is published by the Board of Governors of the Federal Reserve System that establishes yields on actively traded U.S. Treasury securities adjusted to constant maturity, under the caption
“Treasury constant maturities”, for the maturity most closely corresponding to the Par Redemption Date (if no maturity is within three months before or after the Par Redemption Date, yields for the two published maturities most closely
corresponding to the Optional Redemption Comparable Treasury Issue shall be determined and the Optional Redemption Treasury Rate shall be interpolated or extrapolated from such yields on a straight-line basis,
rounding to the nearest month); or (2) if such release (or any successor release) is not published during the week immediately prior to the calculation date or does not contain such yields, the rate per annum equal to the semi-annual equivalent yield to maturity of the Optional Redemption Comparable Treasury Issue, calculated using a price for the Optional Redemption Comparable Treasury Issue (expressed as a percentage of its
principal amount) equal to the Optional Redemption Comparable Treasury Price for such Redemption Date; provided that, if the period from the Redemption Date to the Par Redemption Date is less than one year, the weekly average yield on actually
traded U.S. Treasury securities adjusted to a constant maturity of one year will be used. 
 The Optional Redemption Treasury Rate shall be
calculated by the Determination Agent on the third Business Day preceding the Redemption Date. 
 In determining the Optional Redemption
Treasury Rate, the below terms will have the following meaning: 
 “Optional Redemption Comparable Treasury Issue” means,
with respect to the Redemption Date, the U.S. Treasury security selected by the Determination Agent as having an actual or interpolated maturity comparable with the remaining term to the Par Redemption Date that would be utilized, at the time of
selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities denominated in U.S. dollars and of comparable maturity to the remaining term to the Par Redemption Date. 

“Optional Redemption Comparable Treasury Price” means, with respect to the Redemption Date, (i) the arithmetic average
of the Optional Redemption Reference Treasury Dealer Quotations for such Redemption Date (calculated on the third Business Day preceding such Redemption Date), after excluding the highest and lowest such Optional Redemption Reference Treasury Dealer
Quotations, or (ii) if fewer than five such Optional Redemption Reference Treasury Dealer Quotations are received, the arithmetic average of all such quotations, or (iii) if fewer than two such Optional Redemption Reference Treasury Dealer
Quotations are received, then such Optional Redemption Reference Treasury Dealer Quotation. 
 “Determination Agent” means
an investment bank or financial institution of international standing selected by the Company and which may be an affiliate of the Company. 

“Optional Redemption Reference Treasury Dealer” means, with respect to the Redemption Date, each of up to five banks selected
by the Company (following, where practicable, consultation with the Determination Agent, if applicable), or the affiliates of such banks, which are (i) primary U.S. government securities dealers, and their respective successors, or
(ii) market makers in pricing corporate bond issues. 

  
 -8- 

 “Optional Redemption Reference Treasury Dealer Quotations” means, with
respect to each Optional Redemption Reference Treasury Dealer and the Redemption Date, the arithmetic average, as determined by the Determination Agent, of the bid and offered prices (as quoted to the Determination Agent by such Optional Redemption
Reference Treasury Dealer) for the applicable Optional Redemption Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) at 11:00 a.m., New York time, on the third Business Day preceding such Redemption Date. 

Unless the Company defaults on payment of the Redemption Price, interest will cease to accrue on the Redemption Date on the Securities or
portions thereof called for redemption. The Trustee has no responsibility for any calculation or determination in respect of the establishment of the Make-Whole Redemption price and shall be entitled to
receive and rely conclusively upon an Officer’s Certificate executed in accordance with the Base Indenture that states the Make-Whole Redemption price. 

SECTION 2.05 Loss Absorption Disqualification Event Redemption. If a Loss Absorption Regulations Event occurs on or after the Issue
Date that does, or would be likely to (in the opinion of the Company, the PRA or the Relevant U.K. Resolution Authority), result in a Loss Absorption Disqualification Event, the Company may, at the Company’s option, at any time, redeem the
Securities, in whole but not in part, at a Redemption Price equal to 100% of the principal amount of the Securities being redeemed together with accrued but unpaid interest, if any, on the principal amount of the Securities to be redeemed to (but
excluding) the Redemption Date. For the avoidance of doubt, except as otherwise set forth in this Seventh Supplemental Indenture, Article 11 of the Base Indenture shall apply to any redemption of Securities pursuant to this Section 2.05. 

SECTION 2.06 Events of Default. The terms of Sections 5.01, 5.02 and 5.03 (except for Sections 5.03(c) and 5.03(f)) of
the Base Indenture shall not apply to the Securities and shall be replaced in their entirety by the enforcement events and remedies set forth in Section 2.07 hereof. 

SECTION 2.07 Enforcement Events and Remedies. 

(a) If a Winding-Up Event occurs, the principal amount of the Outstanding Securities, together with any
accrued but unpaid interest thereon, shall become immediately due and payable, without the need of any further action on the part of the Trustee, the Holders or any other Person. 

(b) If the Company fails to pay any amount that has become due and payable under the Securities and such failure continues for fourteen
(14) days, the Trustee may provide a written notice of such failure to the Company. If within a period of fourteen (14) days following the provision of such notice, the failure continues and has not been cured nor waived (a
“Non-Payment Event”), the Trustee may at its discretion and without further notice to the Company institute proceedings in England (or such other jurisdiction in which the Company may
be organized) (but not elsewhere) for the Company’s winding-up and/or prove in the Company’s winding-up and/or claim in the Company’s liquidation or
administration. 
 (c) In addition to the remedies for a Non-Payment Event provided in
Section 2.07(b) hereof, the Trustee may, without further notice, institute such proceedings against the Company as the Trustee may deem fit to enforce any term, obligation or condition binding on the Company under the Securities or the
Indenture (other than any payment obligation of the Company under or arising from the Securities or the Indenture, including, without limitation, payment of any principal or interest, including Additional Amounts) (such obligation, a

  
 -9- 

 
“Performance Obligation”); provided always that the Trustee (acting on behalf of the Holders and Beneficial Owners of the Securities) and the Holders and Beneficial Owners
of the Securities may not enforce, and may not be entitled to enforce or otherwise claim, against the Company any judgment or other award given in such proceedings that requires the payment of money by the Company, whether by way of damages or
otherwise (a “Monetary Judgment”), except by proving such Monetary Judgment in the Company’s winding-up and/or by claiming such Monetary Judgment in the Company’s administration.

 (d) By its acquisition of the Securities, each Holder and Beneficial Owner of the Securities acknowledges and agrees that such Holder and
Beneficial Owner shall not seek to enforce or otherwise claim, and shall not direct the Trustee (acting on behalf of the Holders and Beneficial Owners of the Securities) to enforce or otherwise claim, a Monetary Judgment against the Company in
connection with the Company’s breach of a Performance Obligation, except by proving such Monetary Judgment in the Company’s winding-up and/or by claiming such Monetary Judgment in the Company’s
administration. 
 (e) Other than the limited remedies specified in this Section 2.07 and subject to Section 2.07(f) hereof, no
remedy against the Company shall be available to the Trustee (acting on behalf of the Holders and Beneficial Owners of the Securities) or the Holders and Beneficial Owners of the Securities whether for the recovery of amounts owing in respect of
such Securities or under the Indenture or in respect of any breach by the Company of any of the Company’s obligations under or in respect of the terms of such Securities or under the Indenture in relation thereto; provided,
however, that the Company’s obligations to, and rights of, the Trustee under Section 6.07 of the Base Indenture and the Trustee’s rights to have money collected applied first to pay amounts due to it under such Section pursuant
to Section 5.06 of the Base Indenture expressly survive any Senior Enforcement Event. 
 (f) Notwithstanding the limitation on remedies
specified in this Section 2.07, (1) the Trustee shall have such powers as are required to be authorized to it under the Trust Indenture Act in respect of the rights of the Holders of the Securities under the provisions of the Indenture and
(2) nothing shall impair the right of a Holder of the Securities under the Trust Indenture Act, absent such Holder’s consent, to sue for any payment due but unpaid with respect to the Securities. No Holder of Securities shall be entitled
to proceed directly against the Company except as described in Section 5.07 of the Base Indenture. 
 SECTION 2.08
Trustee’s Duties. In case of a Senior Enforcement Event with respect to the Securities, the Trustee shall with respect to such Securities exercise such of the rights and powers vested in it by the Indenture, and use the same
degree of care and skill in their exercise, as a prudent person would exercise or use under the circumstances in the conduct of his or her own affairs. For these purposes, a “Senior Enforcement Event” shall occur (i) upon the
occurrence of a Winding-Up Event, (ii) upon the occurrence of a Non-Payment Event or (iii) upon a breach by the Company of a Performance Obligation with
respect to the Securities. 
 SECTION 2.09 Waiver of Certain Past Events of Default. For purposes of the Base Indenture and with
respect to the Securities, Section 5.13 of the Base Indenture shall be replaced in its entirety by the following: 
 “(a) Holders
of not less than a majority in aggregate principal amount of the Outstanding Senior Debt Securities of any series may on behalf of the Holders of all of the Senior Debt Securities of such series waive any past Event of Default that results from a
breach by the Company of a Performance Obligation. Holders of a majority of the aggregate principal amount of the Outstanding Senior Debt Securities of such series shall not be entitled to waive any past Event of Default that results from a Winding-Up Event or a Non-Payment Event. 

  
 -10- 

 (b) Upon the occurrence of any waiver permitted by paragraph (a) above, such Event of
Default shall cease to exist, and any Event of Default with respect to any series arising therefrom shall be deemed to have been cured and not to have occurred for every purpose of this Senior Debt Securities Indenture, but no such waiver shall
extend to any subsequent or other Event of Default or impair any right consequent thereon.” 
 SECTION 2.10 Notice of Defaults
Following an Event of Default. For purposes of the Base Indenture and with respect to the Securities, Section 6.02 of the Base Indenture shall be replaced in its entirety by the following: 

“Within ninety (90) days after the occurrence of any Event of Default hereunder with respect to Senior Debt Securities of any
series, the Trustee shall transmit in the manner and to the extent provided in Section 1.06 to Holders of Senior Debt Securities of such series notice of such Event of Default hereunder actually known to the Trustee, unless such Event of
Default shall have been cured or waived; provided, however, that the Trustee shall be protected in withholding such notice if a trust committee of Responsible Officers of the Trustee determine in good faith that the withholding of such
notice is in the interest of the Holders of Senior Debt Securities of such series.” 
 SECTION 2.11 Applicability of the Term
“Event of Default.” For purposes of the Base Indenture, the term “Event of Default” shall mean “Senior Enforcement Event” as defined in this Seventh Supplemental Indenture, except that the term
“Event of Default” as used in Sections 3.05(c)(ii) and 6.07 of the Base Indenture and Article 8 of the Base Indenture shall mean “Winding-Up Event.” 

SECTION 2.12 Certain Acts of Holders Following an Event of Default. For purposes of the Base Indenture and with respect to the
Securities, Section 1.04(d) of the Base Indenture shall be replaced in its entirety by the following: 
 “Upon receipt by the
Trustee from any Holder of Senior Debt Securities of a particular series of any direction referred to in Section 5.12 with respect to Senior Debt Securities of such series, if the Trustee shall not have taken the action specified in such
direction, then the Trustee may set a record date for determining the Holders of Outstanding Senior Debt Securities of such series entitled to join in such direction. The Trustee will notify the Company and the Holders of Outstanding Senior Debt
Securities of such series of any such record date so fixed. The Holders of Outstanding Senior Debt Securities of such series as of the close of business on such record date, and no other Holders, shall be entitled to join in such direction, whether
or not such Holders remain Holders after such record date.” 
 SECTION 2.13 Notice of Redemption. 

(a) Before the Company may redeem the Securities pursuant to Section 2.04 or Section 2.05 hereof or pursuant to Section 11.09 of
the Base Indenture, the Company shall deliver via DTC or the relevant clearing system(s) (or, if the Securities are definitive Securities, to the Holders at their addresses shown on the register for the Securities) prior notice of not less than
fifteen (15) days, nor more than sixty (60) days, to the Holders of the Securities. The Company shall deliver written notice of such redemption of the Securities to the Trustee at least five (5) Business Days prior to the date on
which the relevant notice of redemption is sent to Holders (unless a shorter notice period shall be satisfactory to the Trustee). Such notice shall specify the Company’s election to redeem the Securities and the date fixed for such redemption
and shall be irrevocable except in the limited circumstances described in paragraphs (b) below. 

  
 -11- 

 (b) If the Company has delivered a notice of redemption pursuant to paragraph (a) of
this Section 2.13, but prior to the payment of the redemption amount with respect to such redemption the Relevant U.K. Resolution Authority exercises its U.K. Bail-in Power with respect to the Securities,
such redemption notice shall be automatically rescinded and shall be of no force and effect, and no payment in respect of the redemption amount shall be due and payable. 

(c) If any event specified in paragraph (b) above occurs, the Company shall promptly deliver notice to the Holders of the Securities via
DTC or the relevant clearing system(s) (or, if the Securities are definitive Securities, to the Holders at their addresses shown on the shown on the register for the Securities) and to the Trustee directly, specifying the occurrence of the relevant
event. 
 SECTION 2.14 Acknowledgement with respect to Treatment of EEA BRRD Liabilities. Notwithstanding and to the exclusion
of any other term of the Indenture, this Seventh Supplemental Indenture or any other agreements, arrangements, or understanding between the BRRD Party, on the one hand, and the Company, on the other hand, the Company acknowledges and accepts that an
EEA BRRD Liability arising under the Indenture and this Seventh Supplemental Indenture may be subject to the exercise of EEA Bail-in Powers by the Relevant EEA Resolution Authority, and acknowledges, accepts,
and agrees to be bound by: 
 (a) the effect of the exercise of EEA Bail-in Powers by the Relevant
EEA Resolution Authority in relation to any EEA BRRD Liability that (without limitation) may include and result in any of the following, or some combination thereof: 

(i) the reduction of all, or a portion, of the EEA BRRD Liability or outstanding amounts due thereon; 

(ii) the conversion of all, or a portion, of the EEA BRRD Liability into shares, other securities or other obligations of the
BRRD Party or another person, and the issue to or conferral on the Company of such shares, securities or obligations; 

(iii) the cancellation of the EEA BRRD Liability; or 

(iv) the amendment or alteration of any interest, if applicable, thereon, the maturity or the dates on which any payments are
due including by suspending payment for a temporary period. 
 (b) the variation of the terms of the Indenture or this Seventh Supplemental
Indenture, as deemed necessary by the Relevant EEA Resolution Authority, to give effect to the exercise of EEA Bail-in Powers by the Relevant EEA Resolution Authority in respect of the BRRD Party. 

  
 -12- 

 For these purposes: 

“Bail-in Legislation” means in relation to a member state of the European
Economic Area or the United Kingdom which has implemented, or which at any time implements, the BRRD, the relevant implementing law, regulation, rule or requirement as described in the EU Bail-in Legislation
Schedule from time to time. 
 “BRRD” means EU Directive 2014/59/EU of the European Parliament and of the Council
establishing a framework for the recovery and resolution of credit institutions and investment firms. 
 “BRRD Party” means
The Bank of New York Mellon SA/NV, Luxembourg Branch, solely and exclusively in its role as Senior Debt Security Registrar under the Indenture and this Seventh Supplemental Indenture. For the avoidance of doubt, The Bank of New York Mellon, London
Branch, as Trustee and Paying Agent and in any other capacity under the Indenture or this Seventh Supplemental Indenture is not a BRRD Party under the Indenture or this Seventh Supplemental Indenture. 

“EEA Bail-in Power” means any
Write-down and Conversion Powers as defined in the EU Bail-in Legislation Schedule, in relation to the relevant Bail-in
Legislation. 
 “EEA BRRD Liability” means a liability of the BRRD Party to the Company under the Indenture or this Seventh
Supplemental Indenture, if any, in respect of which the EEA Bail-in Power may be exercised. 

“EU Bail-in Legislation Schedule” means the document described as such, then
in effect, and published by the Loan Market Association (or any successor person) from time to time at http://www.lma.eu.com. 

“Relevant EEA Resolution Authority” means the resolution authority with the ability to exercise any EEA Bail-in Powers in relation to the BRRD Party. 
 SECTION 2.15 Acknowledgement with Respect to Treatment
of BRRD Liabilities. Any references to the “Trustee” in Article 12.02 of the Base Indenture shall be deemed to refer to the Trustee and The Bank of New York Mellon SA/NV, Luxembourg Branch. 

ARTICLE III 

MISCELLANEOUS PROVISIONS 

SECTION 3.01 Effectiveness. This Seventh Supplemental Indenture shall become effective upon its execution and delivery. 

SECTION 3.02 Original Issue. The Securities may, upon execution of this Seventh Supplemental Indenture, be executed by the Company and
delivered by the Company to the Trustee for authentication, and the Trustee shall, upon a Company Order, authenticate and deliver such Securities as in such Company Order provided. 

SECTION 3.03 Ratification and Integral Part. The Base Indenture as supplemented by this Seventh Supplemental Indenture, is in all
respects ratified and confirmed, including without limitation all the rights, immunities and indemnities of the Trustee, and this Seventh Supplemental Indenture shall be deemed an integral part of the Base Indenture in the manner and to the extent
herein and therein provided. 

  
 -13- 

 SECTION 3.04 Priority. This Seventh Supplemental Indenture shall be deemed part of
the Indenture in the manner and to the extent herein and therein provided. The provisions of this Seventh Supplemental Indenture shall, with respect to the Securities and subject to the terms hereof, supersede the provisions of the Base Indenture to
the extent the Base Indenture is inconsistent herewith. 
 SECTION 3.05 Not Responsible for Recitals or Issuance of Securities.
The recitals contained herein and in the Securities, except the Trustee’s certificate of authentication, shall be taken as the statements of the Company, and neither the Trustee nor any authenticating agent assumes any responsibility for
their correctness. The Trustee makes no representations as to the validity or sufficiency of this Seventh Supplemental Indenture or of the Securities, except that the Trustee represents and warrants that it has duly authorized, executed and
delivered this Seventh Supplemental Indenture. Neither the Trustee nor any authenticating agent shall be accountable for the use or application by the Company of the Securities or the proceeds thereof. 

SECTION 3.06 Successors and Assigns. All covenants and agreements in the Base Indenture, as supplemented and amended by this Seventh
Supplemental Indenture, by the Company shall bind its successors and assigns, whether so expressed or not. 
 SECTION 3.07
Counterparts. This Seventh Supplemental Indenture may be executed manually, by facsimile or by electronic signature in any number of counterparts, each of which so executed shall be deemed to be an original, but all such counterparts shall
together constitute but one and the same instrument. The exchange of copies of this Seventh Supplemental Indenture and of signature pages by facsimile, email or other electronic format (i.e., “pdf,” “tif” or “jpg”)
transmission or other electronically-imaged signature (including, without limitation, DocuSign or AdobeSign) or transmission shall constitute effective execution and delivery of this Seventh Supplemental Indenture as to the parties hereto and may be
used in lieu of the original Seventh Supplemental Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile, email or other electronic format (i.e., “pdf,” “tif” or “jpg”) (including, without
limitation, DocuSign or AdobeSign) shall be deemed to be their original signatures for all purposes. Unless otherwise provided herein or in the Securities, the words “execute,” “execution,” “signed,” and
“signature” and words of similar import used in or related to any document to be signed in connection with this Seventh Supplemental Indenture, any Securities or any of the transactions contemplated hereby or thereby (including amendments,
waivers, consents and other modifications) shall be deemed to include electronic signatures and the keeping of records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed signature
in ink or the use of a paper-based recordkeeping system, as applicable, to the fullest extent and as provided for in any applicable law, including the Federal Electronic Signatures in Global and National Commerce Act, the New York State Electronic
Signatures and Records Act, and any other similar state laws based on the Uniform Electronic Transactions Act. 
 SECTION 3.08 Governing
Law. This Seventh Supplemental Indenture and the Securities shall be governed by and construed in accordance with the laws of the State of New York, except for the waiver of set-off provisions set forth in
Section 5.03(c) of the Base Indenture, which shall be governed by and construed in accordance with English law, and except that the authorization and execution of this Seventh Supplemental Indenture and the Securities shall be governed (in
addition to the laws of the State of New York relevant to execution) by the respective jurisdictions of organization of the Company and the Trustee, as the case may be. 

{Signature Page Follows} 

  
 -14- 

 IN WITNESS WHEREOF, the parties hereto have caused this Seventh Supplemental Indenture to be
duly executed as of the day and year first above written. 
  

			
	BARCLAYS PLC
		
	By:	 	 /s/ Miray Muminoglu

		 	Name: Miray Muminoglu
		 	Title: Managing Director
		 	

  

			
	 THE BANK OF NEW YORK MELLON,
LONDON BRANCH, AS TRUSTEE AND PAYING AGENT

		
	By:	 	 /s/ Thomas Burgess

		 	Name: Thomas Burgess
		 	Title: Authorized Signatory

  

			
	 THE BANK OF NEW YORK MELLON SA/NV,
LUXEMBOURG BRANCH, AS SENIOR DEBT SECURITY REGISTRAR

		
	By:	 	 /s/ Thomas Burgess

		 	Name: Thomas Burgess
		 	Title: Authorized Signatory

  
 {Signature Page to
Seventh Supplemental Indenture} 

 ANNEX I 

Interest Terms of the Securities 

Interest Terms of the Securities 
  

			
	Interest Rate:	  	From (and including) the Issue Date to (but excluding) the Reset Date, the Securities will bear interest at a rate of 2.645% per annum (the “Initial Interest Rate”). From (and including) the Reset Date to (but
excluding) the Maturity Date (the “Reset Period” ), the applicable per annum interest rate (the “Subsequent Interest Rate”) will be equal to the sum, as determined by the Calculation Agent, of the then-prevailing
U.S. Treasury Rate (such term subject to the provisions described below) on the Reset Determination Date, plus 1.900% (the “Margin”).
		
	Interest Payment Dates:	  	Semi-annually in arrear on June 24 and December 24 in each year, commencing on December 24, 2020 (each, an “Interest Payment Date”). If any Interest Payment Date would fall on a day that is not a
Business Day, the Company will pay interest on the next succeeding Business Day, but interest on that payment will not accrue during the period from and after the scheduled Interest Payment Date.
		
	Reset Date:	  	June 24, 2030 (the “Reset Date”)
		
	Reset Determination Date:	  	The second Business Day immediately preceding the Reset Date (the “Reset Determination Date”).
		
	Day Count:	  	30/360, Following, Unadjusted.
		
	Calculation Agent:	  	The Bank of New York Mellon, London Branch, or its successor appointed by the Company.
		
	Par Redemption Date:	  	June 24, 2030.
		
	Calculation of U.S. Treasury Rate:	  	The Calculation Agent will determine the Subsequent Interest Rate for the Securities by reference to the then-prevailing U.S. Treasury Rate, on the Reset Determination Date. Promptly upon such determination, the Calculation Agent
will notify the Company and the Trustee (if the Calculation Agent is not the Trustee) of the Subsequent Interest Rate. All determinations and any calculations made by the Calculation Agent for the purposes of calculating the Subsequent Interest Rate
(or component thereof) shall be conclusive and binding on the holders of the Securities, the Company and the Trustee, absent manifest error. The Calculation Agent shall not be responsible to the Company, holders of the Securities or any third party
for any failure of any Reference Treasury Dealer to provide quotations as requested of them or as a result of the Calculation Agent having acted on any quotation or other information given by any Reference Treasury Dealers which subsequently may be
found to be incorrect or inaccurate in any way.

			
		  	  
 “U.S. Treasury Rate” means, with respect to the Reset
Period, the rate per annum equal to: (1) the yield, under the heading which represents the average for the week immediately prior to the Reset Determination Date, appearing in the most recently published statistical release designated
“H.15,” or any successor publication that is published by the Board of Governors of the Federal Reserve System that establishes yields on actively traded U.S. Treasury securities adjusted to constant maturity, under the caption
“Treasury constant maturities,” for the maturity of one year; or (2) if such release (or any successor release) is not published during the week immediately prior to the Reset Determination Date or does not contain such yields, the
rate per annum equal to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury
Price for such Reset Determination Date.
  
 If the U.S. Treasury Rate cannot be
determined, for whatever reason, as described under (1) or (2) above, “U.S. Treasury Rate” means the rate in percentage per annum as notified by the Calculation Agent to the Company equal to the yield on U.S. Treasury
securities having a maturity of one year as set forth in the most recently published statistical release designated “H.15” under the caption “Treasury constant maturities” (or any successor publication that is published weekly by
the Board of Governors of the Federal Reserve System and that establishes yields on actively traded U.S. Treasury securities adjusted to constant maturity under the caption “Treasury constant maturities” for the maturity of one year) at
5:00 p.m. (New York City time) on the last available date preceding the Reset Determination Date on which such rate was set forth in such release (or any successor release).
  

“Comparable Treasury Issue” means, with respect to the Reset Period, the U.S. Treasury security or securities selected by the Company with a
maturity date on or about the last day of the Reset Period and that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities denominated in U.S. dollars and
having a maturity of one year.
  

			
		  	 “Comparable Treasury Price” means, with respect to the Reset Determination Date, (i) the arithmetic average of the
Reference Treasury Dealer Quotations for the Reset Determination Date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, (ii) if fewer than five such Reference Treasury Dealer Quotations are received, the
arithmetic average of all such quotations, or (iii) if fewer than two such Reference Treasury Dealer Quotations are received, then such Reference Treasury Dealer Quotation.

 
 “Reference Treasury Dealer” means, with respect to the Reset
Determination Date, each of up to five banks selected by the Company, or the affiliates of such banks, which are (i) primary U.S. Treasury securities dealers, and their respective successors, or (ii) market makers in pricing corporate bond
issues denominated in U.S dollars.
  
 “Reference Treasury Dealer
Quotations” means, with respect to each Reference Treasury Dealer and the Reset Determination Date, the arithmetic average, as determined by the Calculation Agent, of the bid and offered prices (such prices being obtained by the Company and
furnished to the Calculation Agent) for the applicable Comparable Treasury Issue, expressed in each case as a percentage of its principal amount, at 11:00 a.m. (New York City time) on the Reset Determination Date.

 EXHIBIT A 

Form of Global Security 
 THIS SECURITY IS
A GLOBAL REGISTERED SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS SECURITY IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (OR ANY SUCCESSOR CLEARING SYSTEM)
(“DTC”), TO BARCLAYS PLC, OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF
DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 This Security is one of a duly authorized issue of securities of the Company (as
defined below) (herein called the “Securities” and each, a “Security”) issued and to be issued in one or more series under and governed by the Senior Debt Securities Indenture, dated as of January 17, 2018 (as
heretofore amended and supplemented, the “Base Indenture”), as amended and supplemented by the Seventh Supplemental Indenture, dated as of June 24, 2020 (the “Seventh Supplemental Indenture” and, together with
the Base Indenture, the “Indenture”). 
 Notwithstanding any other agreements, arrangements, or understandings between the Company and any
Holder or Beneficial Owner of the Securities, by acquiring the Securities, each Holder and Beneficial Owner of the Securities acknowledges, accepts, agrees to be bound by, and consents to, the exercise of any U.K.
Bail-in Power by the Relevant U.K. Resolution Authority (as those terms are defined in the Base Indenture) and the provisions set forth in Section 12.01 of the Base Indenture. 

In accordance with Article 13 of the Base Indenture, each Holder and Beneficial Owner of the Securities that acquires the Securities in the secondary market
shall be deemed to acknowledge, agree to be bound by, and consent to, the same provisions set forth in the Securities and the Indenture to the same extent as the Holders and Beneficial Owners of the Securities that acquire the Securities upon their
initial issuance, including, without limitation, with respect to the acknowledgement and agreement to be bound by, and consent to, the terms of the Securities, including in relation to the provisions contained in Section 5.03(c) and
Section 12.01 of the Base Indenture. 

 2.645% Fixed Rate Resetting Senior Callable Notes due 2031 

No. 00{ } 
 ${ } 

CUSIP NO. 06738E BM6 
 ISIN NO.
US06738EBM66 
 COMMON CODE NO. 219445407 

BARCLAYS PLC, a company duly incorporated and existing under the laws of England and Wales (herein called the “Company”,
which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered assigns, the principal sum of US${ } ({ }) on June 24, 2031 (the
“Maturity Date”), except as otherwise provided herein, and to pay interest thereon, in accordance with the terms hereof. Interest shall accrue on this Security from June 24, 2020 or from the most recent Interest Payment Date
(as defined below) to which interest has been paid or duly provided for, until the principal hereof is paid or made available for payment. Interest shall be paid semi-annually in arrear on June 24 and
December 24 of each year (each, an “Interest Payment Date”). From (and including) June 24, 2020 to (but excluding) June 24, 2030 (the “Reset Date”), the Securities will bear interest at a rate of
2.645% per annum. From (and including) the Reset Date to (but excluding) the Maturity Date, the applicable per annum interest rate (the “Subsequent Interest Rate”) will be equal to the sum, as determined by the Calculation Agent, of the
then-prevailing U.S. Treasury Rate (such term subject to the provisions of Annex I to the Seventh Supplemental Indenture) on the second Business Day immediately preceding the Reset Date, plus 1.900%. 

Subject to the limitations specified on the reverse of this Security, interest on the Securities shall be computed and payable in arrear and
on the basis of a 360 day year of twelve 30 day months. 
 The Calculation Agent, initially the Bank of New York Mellon, London Branch (the
“Calculation Agent”), will determine the Subsequent Interest Rate in any circumstance where the Calculation Agent is so required under the terms of the Securities and the Indenture, in accordance with the provisions set forth in
Annex I to the Seventh Supplemental Indenture. 
 All calculations made by the Calculation Agent for the purposes of calculating the
interest rate on the Securities shall be conclusive and binding on the Holders of the Securities, the Company and the Trustee, absent manifest error. 

If any scheduled Interest Payment Date is not a Business Day, the Interest Payment Date shall be postponed to the next succeeding Business Day
(as defined below), but interest on that payment will not accrue during the period from and after the scheduled Interest Payment Date. If the Maturity Date or date of redemption or repayment is not a Business Day, the payment of interest and
principal and/or any amount payable upon redemption or repayment of the Securities will be made on the next succeeding Business Day, but interest on that payment will not accrue during the period from and after such Maturity Date or date of
redemption or repayment. If the Securities are redeemed, unless the Company defaults on payment of the Redemption Price, interest will cease to accrue on the Redemption Date on the Securities called for redemption. A “Business Day”
means any weekday, other than one on which banking institutions are authorized or obligated by law, regulation or executive order to close in London, England or in the City of New York, United States. 

 The interest so payable, and punctually paid or duly provided for, on any Interest Payment
Date shall, as provided in the Indenture, be paid to the Person in whose name the relevant Security (or any Predecessor Senior Debt Security) is registered at the close of business on the Regular Record Date for such interest. 

No repayment of the principal amount of the Securities or payment of interest on the Securities shall become due and payable after the
exercise of any U.K. Bail-in Power by the Relevant U.K. Resolution Authority, unless such repayment or payment would be permitted to be made by the Company under the laws and regulations of the United Kingdom
and the European Union applicable to the Company. 
 Payments of principal of and interest, if any, on the Securities shall be made in such
coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts and such payments shall be made through one or more Paying Agents appointed under the Indenture to the Holder or
Holders of this Security. Initially, the Paying Agent for the Securities shall be The Bank of New York Mellon, London Branch, One Canada Square, London E14 5AL, United Kingdom and the Place of Payment in respect of the Securities shall be the
Corporate Trust Office of the Trustee, which as of the date hereof is hereby designated for purposes of the Securities initially as the office or agency of the Trustee located at said address. Initially, the Senior Debt Security Registrar for the
Securities shall be The Bank of New York Mellon SA/NV, Luxembourg Branch, 2-4 Rue Eugene Ruppert, Vertigo Building – Polaris, Luxembourg, 2453, Luxembourg (which location shall also be a Place of Payment
for purposes of Section 3.05(a) of the Base Indenture). The Company at any time and from time to time may change the Paying Agent or, subject to Section 9.01 of the Base Indenture, the Place of Payment, and the Senior Debt Security
Registrar without prior notice to the Holders of the Securities, and in such an event the Company may act as Paying Agent or Security Registrar. Payments of principal of and interest on the Securities shall be made by wire transfer of immediately
available funds; provided, however, that in the case of payments of principal, this Security is first surrendered to the Paying Agent. 

This Security shall be governed by and construed in accordance with the laws of the State of New York, except for the waiver of set-off provisions referenced herein and set forth in Section 5.03(c) of the Base Indenture which shall be governed by and construed in accordance with English law. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 All terms used in this Security which are defined in the Indenture shall
have the meanings assigned to them in the Indenture, as defined herein. 
 THIS SECURITY IS NOT A DEPOSIT AND IS NOT COVERED BY THE U.K.
FINANCIAL SERVICES COMPENSATION SCHEME OR INSURED BY THE UNITED STATES FEDERAL DEPOSIT INSURANCE CORPORATION OR ANY OTHER GOVERNMENT AGENCY OF THE UNITED STATES, THE UNITED KINGDOM OR ANY OTHER JURISDICTION. 

 Unless the certificate of authentication hereon has been executed by the Trustee referred to
on the reverse hereof, directly or through an Authenticating Agent, by manual, facsimile or electronic signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any
purpose. 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

					
	 Date: June 24, 2020
	 	 BARCLAYS PLC

			
		 	By:	 	              

		 		 	Name:
		 		 	Title:
			
		 	By:	 	              

		 		 	Name:
		 		 	Title:

 Trustee’s Certificate of Authentication 

This is one of the Securities of the series designated herein referred to in the Indenture. 

 

							
	Date: June 24, 2020	 		 	THE BANK OF NEW YORK MELLON, as Trustee
				
		 		 	By:	 	  

 {Signature Page to Global Security No [•]} 

 (Reverse of Security) 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities” and each, a
“Security”) issued and to be issued in one or more series under and governed by the Senior Debt Securities Indenture, dated as of January 17, 2018 (as heretofore amended and supplemented, the “Base Indenture”),
between the Company and The Bank of New York Mellon, London Branch, as Trustee (herein called the “Trustee,” which term includes any successor trustee under the Indenture (as defined below)) as amended and supplemented by the
Seventh Supplemental Indenture, dated as of June 24, 2020 (the “Seventh Supplemental Indenture” and, together with the Base Indenture, the “Indenture”), and reference is hereby made to the Indenture, the terms
of which are incorporated herein by reference, for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee, the Holders of the Securities and of the terms upon which the Securities
are, and are to be, authenticated and delivered. Insofar as the provisions of the Indenture conflict with this Security, the Indenture shall control for purposes of this Security. All terms used in this Security that are defined in the Indenture and
not otherwise defined herein shall have the meanings assigned to them in the Indenture. 
 This Security is one of the series designated on
the face hereof, limited to an aggregate principal amount of $1,000,000,000, which amount may be increased at the option of the Company if in the future it determines that it may wish to sell additional Securities of this series. References herein
to “this series” mean the series designated on the face hereof. 
 The provisions set forth in Section 10.04 of the
Base Indenture are applicable to this Security. In addition, the Company agrees, to the extent the Company has actual knowledge of such information, to provide the Paying Agent with sufficient information about any modification to the terms of the
Securities for the purposes of determining whether FATCA Withholding Tax applies to any payment of principal or interest in the Securities. 

The Company may redeem the Securities pursuant to Section 2.04 of the Seventh Supplemental Indenture. The Company may also redeem the
Securities pursuant to Section 11.09 of the Base Indenture and/or Section 2.05 of the Seventh Supplemental Indenture. Any redemption of Securities by the Company is subject to the notice period and provisions set forth in Sections 11.02
and 11.04 of the Base Indenture and in Section 2.13 of the Seventh Supplemental Indenture, and to the conditions set forth in Section 11.10 of the Base Indenture. 

The Company may repurchase the Securities pursuant to Section 11.12 of the Base Indenture. 

All authority conferred or agreed to be conferred by each Holder and Beneficial Owner pursuant to this Security, including the consents given
by such Holder and Beneficial Owner, shall be binding upon the successors, assigns, heirs, executors, administrators, trustees in bankruptcy and legal representatives of such Holder and Beneficial Owner. 

The Securities shall constitute the Company’s direct, unconditional, unsecured and unsubordinated obligations and shall rank as set forth
in Section 2.01(k) of the Seventh Supplemental Indenture. 

 The Securities are subject to the waiver of set-off
provisions set forth in Section 5.03(c) of the Base Indenture. 
 This Security is subject to the provisions regarding the U.K. Bail-in Power Acknowledgement set forth in Section 12.01 of the Base Indenture, subject to the provisions of Section 2.14 of the Seventh Supplemental Indenture. 

The Securities are subject to provisions set forth in Article 5 of the Base Indenture, provided that the terms of Section 5.01,
Section 5.02 and Section 5.03 (except for Section 5.03(c) and Section 5.03(f)) of the Base Indenture shall not apply to the Securities and shall be replaced in their entirety by the enforcement events and remedies set forth in
the second and third following paragraphs and as contemplated by Section 2.07 of the Seventh Supplemental Indenture. 
 The Securities
will also be subject to the limitation of remedies provisions set forth in Section 2.07 of the Seventh Supplemental Indenture, and the provisions of Section 2.08, Section 2.09, Section 2.10, Section 2.11 and
Section 2.12 of the Seventh Supplemental Indenture. 
 If a Winding-Up Event occurs, the
principal amount of this Security, together with any accrued but unpaid interest thereon, shall become immediately due and payable, without the need of any further action on the part of the Trustee, the Holders or any other Person. 

If a Non-Payment Event occurs, the Trustee may, at its discretion, and without further notice to the
Company, institute proceedings in England (or such other jurisdiction in which the Company may be organized) (but not elsewhere) for the winding-up of the Company and/or prove in a winding-up of the Company and/or claim in a liquidation or administration of the Company. 
 The Indenture
permits the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities to be affected under the Indenture as contemplated by Article 9 of the Base Indenture. To the extent
required by the U.S. Trust Indenture Act of 1939, as amended, but otherwise notwithstanding any other provision in this Security, the Holder of this Security shall have the right to receive (subject to Section 3.07 of the Base Indenture)
payment of any principal of, and interest on, this Security when due (or, in the case of redemption, on or after the Redemption Date), and to institute suit for the enforcement of any such payment, and such rights shall not be impaired without the
consent of such Holder or holder. 
 This Security, and any other Securities of this series and of like tenor, are issuable only in
registered form without coupons in initial denominations of $200,000 and increments of $1,000 thereafter. The denominations cannot be changed without the consent of the Trustee. The provisions on registration, transfer, or exchange, of the
Securities set forth in Section 3.05 of the Base Indenture are applicable to the Securities. 
 No service charge shall be made for any
such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

 Prior to due presentment of this Security for registration of transfer, the Company, the
Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent
shall be affected by notice to the contrary. 
 This Security shall be governed by and construed in accordance with the laws of the State
of New York, except for the waiver of set-off provisions referenced herein and set forth in Section 5.03(c) of the Base Indenture, which shall be governed by and construed in accordance with English law.

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