Document:

EX-10.62

 Exhibit 10.62 

***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 

and 240.24b-2. 

LICENSE AGREEMENT FOR 

INTERFERON GAMMA 
 This
Agreement is entered into effective as of May 5, 1998, (“Effective Date”) by and between Connetics Corporation, a Delaware corporation with its principal office at 3400 West Bayshore Road, Palo Alto, California 94303
(“Connetics”), and Genentech, Inc., a Delaware corporation with its principal office at 1 DNA Way, South San Francisco, California 94080 (“Genentech”). 

WHEREAS, Connetics wishes to obtain a non-exclusive license to manufacture and an exclusive license to
use, sell, offer for sale and import Interferon Gamma (as defined herein) in the United States for the treatment of certain medical disorders; 

WHEREAS, in consideration for the foregoing, Connetics will issue to Genentech shares of Connetics Common Stock on the terms and conditions set
forth in that certain stock purchase agreement between Genentech and Connetics of even date herewith (the “Stock Agreement”); 

WHEREAS, Genentech will manufacture and supply Connetics with Interferon Gamma-1B (as defined herein)
under the terms and conditions set forth in that certain supply agreement between Genentech and Connetics of even date herewith (the “Supply Agreement”); 

WHEREAS, Connetics and Genentech are parties to that certain Agreement on Interferon Gamma-1B dated
December 8, 1995 (the “Prior Agreement”) and desire to terminate the Prior Agreement effective as of the date hereof and to accept the rights and 

  
 1. 

 
obligations created pursuant hereto in lieu of the rights and obligations under the Prior Agreement; and 

WHEREAS, Genentech and Connetics therefore agree to undertake the foregoing, all under the terms and conditions set forth in this Agreement and
for the consideration set forth herein and in the Stock Agreement. 
 NOW, THEREFORE, in consideration of the mutual promises contained
herein, the Parties agree as follows: 
  

	1.0	Definitions 

 1.1       “Best Efforts” shall
mean every necessary and prudent effort of a Party applied in a prompt, commercially reasonable manner, to the maximum extent reasonably allowed by such Party’s available financial resources, taking into account all of such Party’s
business commitments for such financial resources. 
 1.2       “Biogen License” shall mean that
certain license agreement between Genentech and Biogen, Inc. (“Biogen”) dated January 5, 1990, as amended on November 23, 1992. 

1.3       “Biogen License Rights” shall mean all sublicenseable rights granted to Genentech by
Biogen under the Biogen License. 
 1.4      “BLA” shall mean Biologics License Application. 

1.5      “Bulk Product” shall mean Interferon Gamma-1B provided
as bulk protein manufactured in compliance with Good Manufacturing Practices, pursuant to applicable FDA regulatory approvals and supplied to Connetics in such a form and in such containers as shall be mutually determined by Genentech and Connetics
and as described in the Supply Agreement. 

  
 2. 

 1.6       “C.F.R.” shall mean Code of Federal
Regulations. 
 1.7       “CGD” shall mean chronic granulomatous disease. 

1.8       “Connetics Knowhow” shall mean all proprietary information, methods, processes,
techniques and data that have not been publicly disclosed, that relate to Interferon Gamma and that arise out of Connetics’ and its sublicensees’ efforts in the development of Interferon Gamma (including Interferon Gamma as part of a
Licensed Product) hereunder and that on the Effective Date and hereafter during the term of this Agreement are owned or controlled by Connetics or its sublicensees or under which Connetics or its sublicensees otherwise has the right to grant
licenses or sublicenses. 
 1.9       “Connetics Patent Rights” shall mean all patents, patent
applications and any patents issuing therefrom, together with any substitutions, extensions, reexaminations, reissues, renewals, divisions, continuations and
continuations-in-part thereof, that (a) claim inventions constituting Interferon Gamma or its manufacture or use that arise out of Connetics’ or its
sublicensee’s efforts in the development of Interferon Gamma (including Interferon Gamma as part of a Licensed Product) hereunder during the term of this Agreement, and (b) are owned by Connetics or its sublicensees or under which
Connetics or its sublicensees otherwise has the right to grant licenses or sublicenses as provided herein. 

1.10    “ELA” shall mean Establishment License Application. 

1.11    “FDA” shall mean the United States Food and Drug Administration. 

1.12    “Field of Use” shall mean the administration to humans of Licensed Product for the treatment or
prevention of: (a) any dermatological disease or condition including, without limitation, atopic dermatitis, keloids/hypertrophic scars, pustular psoriasis and scleroderma, but excluding any cancer disease or condition, (b) any infectious
disease or 

  
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condition including, without limitation, fungal, viral and bacterial infections, (c) osteopetrosis, (d) chronic granulomatous disease, (e) pulmonary fibrosis, and (f) asthma.
Notwithstanding the foregoing, the Field of Use shall not include the administration to humans of Licensed Product for the treatment or prevention of any type of arthritis or cardiac or cardiovascular disease or condition, or use of Licensed Product
for any indication or use in the field of oncology or endocrinology. Each of Subsections 1.12 (a) through (f) inclusive shall hereinafter each be referred to individually as an “Area of the Field of Use” and together as the
“Areas of the Field of Use.” 
 1.13     “Finished Product” shall mean Interferon Gamma-1B supplied in vialed form as 100 micrograms of Interferon Gamma-1B protein in a 0.5 ml fill volume and as described in the Supply Agreement, manufactured in compliance
with Good Manufacturing Practices and intended for commercial sale to treat CGD and osteopetrosis and for clinical studies. 
 1.14
    “Fully Burdened Non-human Interferon Gamma Manufacturing Cost” shall mean the cost of Genentech’s production and testing of
Non-human Interferon Gamma, which shall be comprised of the sum of: [...***...]. 
 1.15
    “Gene Therapy” shall mean the therapeutic or prophylactic treatment of a human being with: (a) one or more oligonucleotides or nucleotide sequences, in native form

  
 4. 

***Confidential Treatment Requested 

 
or chemically modified, which are introduced into the body in free form, bound to a carrier molecule, contained in any molecular vesicle (e.g. a liposome), incorporated into or attached to a
vector of any type, contained in any cellular construct and/or contained in any mechanical device or (b) cells which have been manipulated ex vivo using one or more oligonucleotides or nucleotide sequences. 

1.16    “Genentech Knowhow” shall mean all proprietary information, methods, processes, techniques and data that
are in the possession or control of Genentech on the Effective Date or thereafter during the term of this Agreement, that Genentech is free to license or sublicense, that have not been publicly disclosed, and that are specific and reasonably
necessary for the use, sale, offer for sale or importation of Interferon Gamma in the Field of Use in the Territory, but shall not include information regarding the manufacture of Interferon Gamma. 

1.17    “Genentech Manufacturing Knowhow” shall mean all proprietary information, methods, processes, techniques
and data that are in the possession of Genentech at such time as Genentech determines or is required pursuant to the terms of the Supply Agreement to make a manufacturing technology transfer to Connetics, that are not generally known, and that are
specific and reasonably necessary for the manufacture of Interferon Gamma in the Field of Use in the Territory. 

1.18    “Genentech Patent Rights” shall mean all patents and patent applications and any patents issuing
therefrom, together with any extensions, reissues, reexaminations, substitutions, renewals, divisions, continuations and continuations-in-part thereof (a) that are
owned or controlled by Genentech presently or hereafter, during the term of this Agreement, and under which Genentech is free to license or sublicense, and (b) to the extent they claim 

  
 5. 

 
or directly relate to Interferon Gamma or its manufacture or use in the Field of Use, including, without limitation, the patent rights granted under that certain license agreement between
Genentech and [...***...], dated July 16, 1990 (the “[...***...] License”), but specifically excluding any rights granted to Genentech under the Biogen License. Genentech Patent Rights shall include, without limitation,
the patents and patent applications listed in Exhibit A attached hereto. Notwithstanding the foregoing, Genentech Patent Rights shall exclude any rights Genentech acquires after the Effective Date of this Agreement under third-party license
agreements, with the exception of those acquired under the [...***...] License, unless and until the Parties mutually agree on terms and conditions for the sublicense of such rights from Genentech to Connetics. 

1.19    “IND” shall mean Investigational New Drug Application. 

1.20    “Interferon Gamma” shall mean a polypeptide having the 126 amino acid sequence set forth on Exhibit
B or a variant of such sequence having at least 70% homology thereto, or such polypeptide with one or more additional amino acid residue(s) extending from the N-terminus thereof and/or one or more
additional amino acid residue(s) extending from the C-terminus thereof, such polypeptides including, without limitation, Interferon Gamma-1B. 

1.21    “Interferon Gamma-1B” shall mean a single chain polypeptide
containing the 140 amino acid sequence set forth on Exhibit C hereto, i.e., the active ingredient in the ACTIMMUNE® (Interferon Gamma-1B)
Injection product. 
 1.22    “Licensed Product” shall mean any pharmaceutical formulation containing
Interferon Gamma whether alone or together with or incorporated into any other substance or product or material or device, whether active or not, and which (i) but for the licenses 

  
 6. 

***Confidential Treatment Requested 

 
granted hereunder, the manufacture, use, sale, offer for sale or importation of which in the Territory would infringe or contribute to the infringement of Genentech Patent Rights in the
Territory, or (ii) is based upon or incorporates or utilizes Genentech Knowhow. For purposes of clarification, it is understood that this definition shall not include any pharmaceutical formulation which induces the presence or activity of
Interferon Gamma in vivo, or the DNA encoding Interferon Gamma for Gene Therapy, or other biological techniques aimed at establishing or modulating endogenous Interferon Gamma in vivo. 

1.23        “NDA” shall mean New Drug Application. 

1.24        “NDC” shall mean National Drug Code. 

1.25        “Net Sales” shall mean, as to each calendar quarter, the gross invoiced sales
prices charged for all Licensed Products sold by Connetics and its sublicensees in arm’s length transactions to independent third parties during such quarter, after deduction of the following items paid by Connetics and its sublicensees during
such calendar quarter with respect to sales of Licensed Products regardless of the calendar quarter in which such sales were made, provided and to the extent that such items are incurred or allowed and do not exceed reasonable and customary amounts
in the market in which such sales occurred: 
  

	 	(i)	[...***...]; 

  

	 	(ii)	[...***...]; 

  

	 	(iii)	[...***...] 

  
 7. 

***Confidential Treatment Requested 

	 	 	[...***...]; and 

	 	

	 	(iv)	[...***...]. 

  

	 	 	Notwithstanding the foregoing, no deduction shall be made for bad debt expense. 

1.26        “Party” shall mean Genentech or Connetics, and, when used in the plural, shall
mean both of them. 
 1.27        “PLA” shall mean Product License Application. 

1.28        “Territory” shall mean the United States of America and its territories and
possessions. 
 1.29        “Transfer Date” shall mean, unless otherwise mutually agreed to
by the Parties, the last day of the second full calendar month following the first delivery by Connetics to Genentech of Connetics’ labeling and packaging materials for Genentech’s use in labeling and packaging Finished Product, pursuant
to a purchase order submitted by Connetics and accepted by Genentech, to be sold commercially by Connetics for treatment of CGD, provided that the activities set forth on Exhibit H have been completed. 

 

	2.0	License Grant 

  

	 	2.1	Patent and Knowhow License Grant 

 (a)        Genentech
grants to Connetics an exclusive license, even as to Genentech, under Genentech Patent Rights and under Genentech Knowhow to use, sell, offer 

  
 8. 

***Confidential Treatment Requested 

 
for sale and import (but not to make or have made) Licensed Products in the Field of Use in the Territory, (excluding, with respect to the fields of (i) scleroderma and (ii) infectious
disease or condition caused by human papillomavirus, Licensed Products containing any form of Interferon Gamma other than Genentech Gamma Interferon D3, as that term is defined in the Biogen License).
Notwithstanding the foregoing, Genentech reserves the right to use (but not to import, offer for sale or sell) Licensed Products within the Field of Use for research purposes. 

(b)       Genentech grants to Connetics a non-exclusive license
under Genentech Patent Rights and under Genentech Knowhow to use, sell, offer for sale and import (but not to make or have made) Licensed Products containing any form of Interferon Gamma other than Genentech Gamma Interferon D3 (as that term is defined in the Biogen License) in the Territory in the fields of: (i) scleroderma and (ii) infectious disease or condition caused by human papillomavirus. 

(c)       Genentech grants to Connetics a non-exclusive sublicense
under the Biogen License Rights to use, sell, offer for sale and import Licensed Products (excluding Licensed Products containing Biogen Gamma Interferon D0 as that term is defined in the Biogen License)
in the Territory in the fields of scleroderma and infectious disease or condition caused by human papillomavirus. 

(d)       Genentech grants to Connetics a non-exclusive license
under Genentech Patent Rights to make or have made Licensed Products in the Field of Use for use and sale in the Territory. 

(e)       Genentech grants to Connetics a non-exclusive license
under Genentech Patent Rights and Genentech Knowhow to use non-human animal species derived 

  
 9. 

 
homologues of Interferon Gamma (Non-human Interferon Gamma) for non-commercial research purposes to support the
Field of Use in the Territory. 
 Except as expressly granted herein, there are no implied licenses under the Genentech Patent Rights or any
other intellectual property rights owned or controlled by Genentech. 
 2.2         Trademark
License Grant 
 (a)       Genentech hereby grants to Connetics a
non-exclusive, royalty-free license to use the trademark, ACTIMMUNE, for the advertising, promotion, marketing, distribution and sale of Licensed Products in the Territory. Connetics shall have the right to
grant sublicenses to such non-exclusive license, subject, however, to the prior written consent of Genentech,. which consent shall not be unreasonably withheld. Genentech agrees not to grant any other licenses
to use the ACTIMMUNE trademark without the consent of Connetics, which consent shall not be unreasonably withheld. 

(b)       Use of the Mark. In using the ACTIMMUNE mark, Connetics shall display said mark in upper case
letters or otherwise display it in a style or size of print distinguishing the mark from any accompanying wording or text. Where feasible, Connetics shall display the registration symbol ® to
the right of and slightly above or below the last letter of the word, ACTIMMUNE. Prior to any new use by Connetics of the ACTIMMUNE mark on product packaging or package inserts for the Licensed Products, Connetics shall notify and provide Genentech
with an example of the proposed use for approval by Genentech, which approval shall not be unreasonably withheld or delayed. Such additional use, with respect to the ACTIMMUNE mark, shall automatically become a part of the license grant under
Section 2.2(a) above. 

  
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 (c)    Quality Control. If Connetics uses the ACTIMMUNE mark for Licensed
Products, such products shall be of at least the quality described in the Specifications therefor as defined in the Supply Agreement. 

(d)    Ownership. Connetics hereby acknowledges Genentech’s exclusive right, title and interest in and to the
ACTIMMUNE mark and agrees that it will not at any time do, or cause to be done, any act or thing contesting or in any way impairing or intending to impair the validity of and/or Genentech’s exclusive right, title and interest in and to the
ACTIMMUNE mark. Connetics will not in any manner represent that it owns the ACTIMMUNE mark and hereby acknowledges that its use of the ACTIMMUNE mark as set forth in Section 2.2(b) above shall not create any rights, title or interest in or to the
ACTIMMUNE mark in its favor, but that all use of the ACTIMMUNE mark by Connetics shall inure to the benefit of Genentech. 

2.3         Sublicenses. 

(a)    Connetics may grant sublicenses under the rights granted in Section 2.1(d) on thirty (30) days prior written
notice to Genentech, subject to Genentech’s prior written approval, which approval shall be at Genentech’s sole discretion. Genentech agrees that [...***...] is acceptable to Genentech as a Connetics’ sublicensee under the
rights granted in Section 2.1(d) for the purpose of manufacturing and supplying Bulk Product and/or Finished Product to Connetics, and/or to its sublicensees under Sections 2.1(a), (b) and (c). In the event that Genentech approves the grant of a
sublicense under Section 2.1(d), Genentech may in its sole discretion, or as agreed by the Parties in the Supply Agreement, agree to grant to Connetics and such approved sublicensee a non-exclusive license
under Genentech Manufacturing Knowhow solely to make or have 

  
 11. 

***Confidential Treatment Requested 

 
made Licensed Products for use and sale by Connetics and its sublicensees in the Field of Use in the Territory, and Genentech shall thereafter disclose to Connetics and such sublicensee such
Genentech Manufacturing Knowhow as soon as reasonably possible. 
 (b)    Connetics may grant one or more sublicenses
under the rights granted in Sections 2.1(a), (b), (c) and (e) in any applicable Area of the Field of Use, on thirty (30) days prior written notice to Genentech, subject to Genentech’s prior written approval, which approval shall not
be unreasonably withheld. 
 (c)    Notwithstanding the above, Connetics may grant one sublicense to InterMune (as
defined in Section 3.1) under any or all of the rights granted in Sections 2.1 and 2.2(a) above without Genentech’s prior written approval. InterMune (but no other sublicensee of Connetics) may grant further sublicenses under Sections 2.1
and 2.2(a) to the extent that Connetics has the right to do so pursuant to the provisions of this Section 2.3 and Section 2.2(a). Connetics and InterMune shall give Genentech a copy of any sublicense agreement entered into by either of them
with a third party pursuant to this Agreement as soon as reasonably possible after execution, provided that Connetics and InterMune may each redact from such copies text of information or provisions that are not relevant to this Agreement and the
rights and obligations of the Parties hereunder. Genentech agrees to permit InterMune to perform Connetics’ rights and obligations under Section 2.2(b), (c) and (d), Section 2.5, Sections 3.1 through 3.8 and Article 4.0 of this Agreement
(excluding matters related to any alleged breach of the Agreement, or dispute between the Parties concerning the performance of this Agreement, under such enumerated Sections and Article), to the extent such rights and obligations are sublicensed to
InterMune by Connetics, and Genentech agrees to deal with InterMune in lieu of Connetics as if it were Connetics 

  
 12. 

 
hereunder for purposes of performance under such enumerated Sections and Article, provided that Connetics shall remain liable and responsible for performance of all of the obligations of
Connetics and InterMune under this Agreement. In the event that Connetics sublicenses all of its rights under Section 2.1 and 2.2(a) to InterMune pursuant to a written sublicense which provides that InterMune (and not Connetics) shall make,
have made, use, sell, offer for sale, import and develop Licensed Products in all Areas of the Field of Use in the Territory, then Genentech agrees to permit InterMune to also perform Connetics’ rights and obligations under Articles 5.0 and 6.0
and Sections 8.2 through 8.8 of this Agreement (excluding matters related to any alleged breach of the Agreement, or dispute between the Parties concerning the performance of this Agreement, under such enumerated Sections and Articles), and
Genentech also agrees to deal with InterMune in lieu of Connetics as if it were Connetics hereunder for purposes of performance under such enumerated Sections and Articles, provided that Connetics shall remain liable and responsible for performance
of all of the obligations of Connetics and InterMune under this Agreement. In the event that InterMune sublicenses any of its rights to a third party pursuant to this Agreement, such sublicensee shall not have the right to perform the rights and
obligations of Connetics or InterMune under the Sections and Articles enumerated above, and Genentech shall not have any obligation to deal directly with such sublicensee. Notwithstanding the above provisions of this Section 2.3(c), with respect to
any dispute concerning InterMune’s performance, or alleged breach by InterMune, of any applicable term of this Agreement, Genentech shall have the right to deal directly with Connetics, and to proceed either against InterMune or directly
against Connetics, in Genentech’s sole discretion, to enforce this Agreement. 

  
 13. 

 (d)    In the event of the grant of any sublicense by Connetics (including
such grant to InterMune) or by InterMune, the sublicensee shall be subject to all of the applicable obligations of Connetics hereunder. Connetics guarantees to Genentech the performance of Connetics’ applicable obligations hereunder by
Connetics’ sublicensees and by InterMune’s sublicensees. 
 2.4         Grant Back
License. Connetics hereby grants to Genentech under any Connetics Patent Rights and Connetics Knowhow, a nonexclusive, sublicenseable license in the Territory to make, have made, use, sell, offer for sale and import Interferon Gamma for any use
outside of the Field of Use, with a royalty rate of [...***...] payable to Connetics on net sales of Interferon Gamma by Genentech, its affiliates and its sublicensees covered by such Connetics Patent Rights or incorporating such Connetics
Knowhow. Genentech shall have the right to grant sublicenses under such license, subject to the prior written approval of Connetics, which approval shall not be unreasonably withheld. The license granted to Genentech under this Section 2.4
shall expire on the later of: (a) the expiration of the last to expire of any Connetics Patent Rights or (b) if Connetics Knowhow was used, twenty (20) years from the first commercial sale of Interferon Gamma outside the Field of Use
by Genentech, its affiliates or its sublicensees hereunder. As used herein, “net sales” shall have the equivalent definition given to Net Sales in Section 1.25 above. 

2.5         Data Transfer and Cooperation 

(a)    Genentech shall provide Connetics with reasonable access to all such relevant information and materials in its
possession (subject to Genentech’s own internal reasonable needs for the information and materials) that Connetics reasonably needs to develop and commercialize Licensed Products in the Field of Use under the license granted 

  
 14. 

***Confidential Treatment Requested 

 
to Connetics under Section 2.1 above. Connetics shall submit requests for such information to Genentech’s Clinical Collaborations Operations Department - Medical Affairs at the address
set forth at the beginning of this Agreement. Access to such information and materials shall be made in a timely and orderly fashion and in a manner such that the value of the accessed information is preserved in all material respects. 

(b)      Connetics shall provide Genentech with reasonable access to such relevant information and materials in
its possession as is reasonably necessary for Genentech to exercise the license rights granted by Connetics under Section 2.4 and Genentech shall submit requests for such information to Connetics’ Vice President - Intellectual Property at
the address set forth at the beginning of this Agreement. Access to such information and materials shall be made in a timely and orderly fashion and in a manner such that the value of the accessed information is preserved in all material respects.

 (c)      Commencing on May 1, 1998 Connetics or its sublicensees shall be responsible for any costs
associated with maintaining the Genentech breeding colony of interferon gamma gene knock-out mice at Charles River Labs (the “Knock-Out Mice”). In
consideration for Connetics paying these costs, Genentech hereby transfers all ownership of such particular Knock-Out Mice to Connetics, subject to Genentech’s right to use such Knock-Out Mice and the progeny thereof for Genentech’s own research purposes to the extent such Knock-Out Mice are not being used (or planned to be used) by Connetics or
its sublicensees. If Connetics and its sublicensees wish to discontinue the maintenance of such Knock-Out Mice colony, Connetics shall give Genentech sixty (60) days prior notice and the right to take
over such maintenance, at Genentech’s sole discretion, before Connetics discontinues such maintenance. Connetics acknowledges that Genentech has, prior to the 

  
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Effective Date hereof, transferred interferon gamma gene knock-out mice to other third parties. 

(d)      Connetics shall use its Best Efforts to obtain a license from the FDA, which shall include obtaining a
U.S. license number and an NDC number, to enable the effective transfer from Genentech to Connetics of the PLA for CGD on file with the FDA (the “CGD PLA”). Genentech shall use its Best Efforts to assist such transfer, to the extent
reasonably requested by Connetics. Genentech also shall, before the Transfer Date, reasonably assist Connetics in initiating Connetics’ sales of Licensed Product in the Area of the Field of Use of CGD by transferring to Connetics information
reasonably requested by Connetics that relates to such sales efforts for CGD. Connetics shall reimburse Genentech for all reasonable costs associated with Genentech’s providing of such information within ninety (90) days of Connetics’
receipt of an invoice of such cost from Genentech. 
 (e)      Genentech shall transfer the CGD PLA, IND and
copies of all material correspondence with the FDA regarding such PLA and IND to Connetics as soon as reasonably possible after the Effective Date of this Agreement and Connetics shall be responsible for all activities, at its own cost, necessary to
maintain the CGD PLA and IND and keep them active with the FDA after such date. Connetics shall reimburse Genentech for 50% of all reasonable costs associated with Genentech’s transfer of the CGD PLA, IND and such FDA correspondence within
ninety (90) days of Connetics’ receipt of an invoice of such cost from Genentech. 

(f)      Connetics shall not commence marketing and sales of Finished Product prior to the Transfer Date. On the
Transfer Date, Genentech shall transfer to Connetics the responsibility for all marketing and sales of Finished Product in the Field of Use in the 

  
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Territory, provided that all the activities listed on Exhibit H attached hereto are completed. The Parties shall use Best Efforts to complete the tasks set forth on Exhibit H as expeditiously as
possible. 
 (g)       Genentech shall provide Connetics with reasonable access to relevant data and
regulatory information in its possession in the form existing as of the Effective Date, whether written or electronic, including all clinical safety data and clinical efficacy data that are related to the manufacture, use and sale of Interferon
Gamma within the Field of Use and the right to cross-reference Genentech’s IND, ELA, and PLA information for Interferon Gamma in any Genentech regulatory filings related to Interferon Gamma within the Field of Use. Other than as expressly set
forth herein, Genentech shall have no further obligation with respect to Connetics’ efforts to obtain the FDA license referred to in Section 2.5(d) above. At Genentech’s sole discretion, Genentech may participate in regulatory filings in
the Field of Use in the Territory if the Parties agree that Genentech’s participation in such regulatory filings would expedite the approval and commercialization of a Licensed Product. Connetics shall reimburse Genentech for all reasonable
costs associated with Genentech’s providing of data and regulatory information and referencing within ninety (90) days of Connetics’ receipt of an invoice of such cost from Genentech. Connetics shall submit requests for such
information to Genentech’s Clinical Collaborations Operations Dept. - Medical Affairs at the address set forth in the beginning of this Agreement. Such requests shall not be submitted more than two (2) times in any twelve (12) month
period, unless such requests concern information that is critical to product registration activities. Access to such information shall be made in a timely and orderly fashion and in a manner such that the value of the accessed information is
preserved in all material respects. 

  
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 (h)       To the extent reasonably requested by Genentech,
Connetics shall provide Genentech with access to all data and regulatory information in its possession, whether written or electronic, in the form existing as of the date of Genentech’s request, including all clinical safety data and clinical
efficacy data, that directly relates to the use of Interferon Gamma outside the Field of Use and shall give Genentech the right to cross-reference Connetics’ IND, ELA, BLA and PLA information, if applicable, in any Genentech regulatory filings
that are related to the use or sale of Interferon Gamma outside the Field of Use. Genentech shall reimburse Connetics for all reasonable actual costs associated with Connetics’ providing of data and regulatory information and referencing within
ninety (90) days of the receipt of an invoice of such cost by Genentech from Connetics. Such requests shall not be submitted more than two (2) times in any twelve (12) month period, unless such requests concern information that is
critical to product registration activities. Access to such information shall be made in a timely and orderly fashion and in a manner such that the value of the accessed information is preserved in all material respects. 

(i)       Commencing from Genentech’s first delivery to Connetics or Intermune of Finished Product for
clinical studies in accordance with the Supply Agreement, Connetics shall thereafter be responsible for supplying ACTIMUNE free of charge to, and funding (if any) of, the third party sponsors of the clinical studies listed in Exhibit D attached
hereto and incorporated herein. Connetics shall enter into clinical research agreements with such third party sponsors governing such studies that commence after the Effective Date hereof. With respect to clinical research agreements between
Genentech and such sponsors in effect prior to the Effective Date, Connetics shall replace Genentech, pursuant to an 

  
 18. 

 
assignment, as a party. ACTIMMUNE (and funding, if any) for all such studies shall be supplied by Connetics to such sponsors as described in such clinical research agreements. 

(j)       As of the Transfer Date, Connetics shall conduct an indigent patient program for Licensed
Products sold for use in the field of CGD. As soon as reasonably possible after Genentech transfers information regarding patients who have participated in Genentech’s indigent patient program, Connetics will inform Genentech whether or not
such patients will be eligible and participating in Connetics’ indigent patient program. 
  

	3.0	Product Development and Milestones 

3.1         Commercialization Milestones. 

(a)        Connetics shall use its Best Efforts to develop, seek FDA clearance for marketing of,
commercialize and sell Licensed Products in the Territory in all Areas of the Field of Use. The Parties acknowledge that a new company, named InterMune Pharmaceuticals, Inc. (“InterMune”), has been incorporated to conduct development and
commercialization of Licensed Products in the Field of Use pursuant to an appropriate sublicense from Connetics to Intermune. Connetics agrees to perform the following Commercialization Milestones no later than the date set forth below opposite the
appropriate Commercialization Milestone description: 
  

			
	 Commercialization Milestone
	  	 Date of Completion

		
	(a) Completion of the formation of InterMune	  	May 1, 1998
		
	(b) Execution of a sublicense agreement granting to InterMune rights, as permitted in this Agreement,	  	June 1, 1998

  
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	necessary to perform development of Licensed Products in the Field	  	
		
	(c) Closing of at least [...***...] in equity financing of InterMune by third parties and/or Connetics	  	July 15, 1998
		
	(d) Closing of at least another additional [...***...] in equity financing of InterMune by third parties and/or Connetics	  	September 1, 1998
		
	(e) Enrollment and active participation of the first patient in the first new clinical trial for a Licensed Product in the Field of Use in the Territory	  	October 1, 1998

 (b) If Connetics fails to perform any of the Commercialization Milestones described in 3.1 (a) through
(e) inclusive by the applicable Date of Completion for any reason within Connetics’ control, then, notwithstanding the termination provisions in Section 11.2 below, Genentech shall have the right to terminate this Agreement and the
licenses granted to Connetics hereunder, upon written notice to Connetics, which termination shall become effective thirty (30) days after Genentech’s sending written notice of such termination, unless such Commercialization Milestone has
been completed prior to the expiration of such thirty day period. If Connetics fails to perform any of the Commercialization Milestones for causes beyond Connetics’ control, Genentech shall not have the termination rights above, provided that
Connetics has mitigated such causes to the extent it can reasonably do so. If Connetics fails to reasonably mitigate such causes, Genentech will have the termination rights described above. In addition, if Genentech 

  
 20. 

***Confidential Treatment Requested 

 
exercises such termination rights above, Genentech shall be automatically granted a co-exclusive (with Connetics and Connetics’ sublicensees),
sublicenseable, royalty-free, worldwide license: (i) to the result of efforts made by Connetics and its sublicensees in the development of Licensed Products hereunder, (ii) to use all regulatory submissions made by Connetics and its
sublicensees hereunder, and (iii) under all Connetics Patent Rights and Connetics Knowhow, arising from the efforts made by Connetics and its sublicensees hereunder in the research and development of Licensed Products, to make, have made, use,
sell, offer for sale or import Licensed Products. Upon Genentech’s exercise of such termination right described above, Connetics shall promptly provide Genentech with copies of all related documentation, whether written or electronic, and
materials, including biological materials, in the form existing as of the effective date of such termination, reasonably necessary for Genentech to exercise its license rights under this Section 3.1(b). Such transfer shall be made in an orderly
fashion and in a manner such that the value in what is being transferred is preserved in all material respects. The foregoing shall constitute Genentech’s exclusive remedies for Connetics failure to complete one or more of the Commercialization
Milestones above, provided, however, that Genentech’s rights and remedies for breach of other provisions of this Agreement, and under the Supply Agreement and the Stock Agreement, shall remain in full force and effect. 

3.2         Diligence 

(a)       Attached hereto as Exhibit E are Connetics’ Clinical Development Milestones (the
“Clinical Development Milestones”) for Licensed Products in the Field of Use and the Dates of Completion for each such milestone. Connetics shall use its Best 

  
 21. 

 
Efforts to adhere to the Dates of Completion as set forth in Exhibit E. Connetics shall notify Genentech in writing when it achieves a Clinical Development Milestone. 

(b)       From time to time, Connetics may suggest modifications to the Clinical Development Milestones
based on new information. Such modifications shall be effective only as mutually agreed upon, in writing, by the Parties. Genentech shall consider such requested modifications in good faith and shall agree to any modifications that are reasonably
necessary to achieve the overall objectives of the development of Licensed Product hereunder. 
 (c)
       In the event that Connetics determines that it will be unable to meet any Date of Completion for a Clinical Development Milestone due to an event within Genentech’s control, including without
limitation, delay in the performance by Genentech of any of its obligations hereunder (e.g. the transfer of technology or materials, including the supply of Interferon Gamma-1B), Connetics shall give prompt
notice to Genentech of such inability and shall specify the amount of delay Connetics believes resulted from such event within Genentech’s control. Unless Genentech disagrees in writing on reasonable grounds with the amount of such delay
specified by Connetics, such Date of Completion will automatically be extended by the length of time of the delay. In the event Genentech disagrees in writing on reasonable grounds with the amount of delay specified by Connetics, the Parties shall
negotiate a new Date of Completion in good faith. 
 (d)       In the event that Connetics determines
that it will be unable to meet any Date of Completion for a Clinical Development Milestone due to an event which would be considered a force majeure (as described in Section 12.9), Connetics shall give prompt written notice to Genentech of such
inability and the length of the delay Connetics believes 

  
 22. 

 
resulted from such force majeure. Unless Genentech disagrees in writing on reasonable grounds with the length of such delay specified by Connetics, such Date of Completion will be automatically
extended by such specified length of time of the delay. In the event Genentech disagrees in writing on reasonable grounds with the length of delay specified by Connetics, the Parties shall negotiate a new Date of Completion in good faith. 

(e)       In the event that Connetics determines that it will be unable to meet any Date of Completion for
a Clinical Development Milestone for reasons other than (i) force majeure and/or (ii) an event within Genentech’s control, Connetics shall notify Genentech of such inability, identifying the nature of the inability with reasonable
specificity and may ask Genentech for a reasonable extension of time in which to complete such Clinical Development Milestone. In Genentech’s sole discretion, Genentech may grant Connetics such an extension to complete such Clinical Development
Milestone. 
 (f)       Except as set forth in Sections 3.2(c) or 3.2(d) or in the event that Genentech
shall have agreed to an extension of the time to complete a Clinical Development Milestone as set forth in Section 3.2(e), if Connetics fails to complete a Clinical Development Milestone by the corresponding Date of Completion with respect to one or
more of the Areas of the Field of Use (other than in the dermatological Area of the Field of Use as described in Section 1.12(a) above) Genentech shall have the right to terminate this Agreement with respect to such Area(s) of the Field of Use, by
providing Connetics written notice thereof, and the termination of the Agreement with respect to such Area(s) of the Field of Use shall be effective thirty (30) days after Connetics’ receipt of such notice unless such Clinical Development
Milestone shall have been met prior to the expiration of such thirty (30) day period, and such termination shall be Genentech’s exclusive remedy for such failure 

  
 23. 

 
of Connetics to complete such Clinical Development Milestone. Upon such termination of the Agreement with respect to such Area(s) of the Field of Use: (i) Genentech shall automatically have
all the rights set forth in Sections 11.3(a) and (b) solely with respect to such Area(s) of the Field of Use; and (ii) any sublicense(s) granted by Connetics with respect to such Area(s) of the Field of Use shall not automatically
terminate, but instead, Genentech shall have the option to either terminate or continue this Agreement with respect to such Area(s) of the Field of Use with such sublicensee(s). 

3.3       Review of Clinical Development Plan and Marketing Programs. On or about each August 1 during
the term of this Agreement, Connetics shall supply Genentech with a report on Connetics’ development and marketing programs for Licensed Products in the Field of Use in the Territory. The report shall include the following: (i) a
description of Connetics’ progress in such programs during the twelve (12) months prior to the date of each such report, (ii) a description of Connetics’ planned development and marketing programs for the twelve (12) months
after the date of each such report, (iii) a copy of the most recent version of the Clinical Development Milestones (if not previously provided to Genentech), (iv) a copy of all previous versions of the Clinical Development Milestones (if not
previously provided to Genentech), (v) an explanation of any discrepancies between Connetics’ progress during the prior twelve (12) months and the Clinical Development Milestones and (vi) a proposal to address such discrepancies, as
contemplated under Section 3.2. Genentech shall have the right to comment on the Clinical Development Milestones and the development and marketing programs,. and at Genentech’s -discretion, the Parties shall meet to discuss and agree upon
changes to the Clinical Development Milestones. 

  
 24. 

 3.4         New Delivery Forms. Connetics shall have
the right to develop and obtain regulatory approval for the marketing of new delivery forms of Interferon Gamma for use in Licensed Products in the Field of Use in the Territory. 

3.5         Costs of Development. Connetics shall be responsible for all aspects and costs of
development, regulatory approval and registration of Licensed Products. 
 3.6         Joint
Development and Marketing Activities. Upon written notice to Genentech, Connetics and InterMune shall be permitted to discuss and enter into agreements and participate in joint development and marketing activities for Licensed Products in the Field
of Use outside the Territory with other Genentech Interferon Gamma licensees. 

3.7         Compliance with Law and Safety and Adverse Event Reporting. 

(a)       Connetics shall conduct clinical trials hereunder, and shall make, use, sell and distribute
Licensed Products in accordance with all applicable laws and regulations. Genentech and Connetics shall make available to each other during the term of this Agreement all safety data obtained which relates to the use of Licensed Products in the
Field of Use. Connetics will provide to Genentech’s Medical Information and Drug Experience department at the time of filing a copy of each adverse event report or any report, including summary reports, it is required to file under Title 21 or
any other applicable provision of the C.F.R. regarding Interferon Gamma. Genentech will provide Connetics at the time of filing with a copy of each adverse event report or any report, including summary reports, it is required to file regarding
Interferon Gamma under Title 21 or any other applicable provision of the C.F.R.. 
 (b)       Connetics
shall maintain a safety database for all Licensed Products and clinical trials conducted hereunder and shall submit to regulatory agencies all adverse 

  
 25. 

 
event and safety reports required to be filed pursuant to Title 21 or any other applicable provision of the C.F.R. Connetics shall also be responsible for providing product, medical and clinical
information regarding Licensed Product to its customers. 
 3.8         Clinical Development
Reports. During the course of clinical development of Licensed Products and clinical studies conducted by Connetics hereunder, Connetics shall submit to Genentech the reports listed on Exhibit F attached hereto and incorporated herein. Connetics
shall submit such reports to Genentech as promptly as reasonably practicable after such reports are completed or such applicable information is available. 

3.9         Technology Outside the Field of Use 

(a)       Upon mutual written amendment to this Agreement, the Parties may expand the Field of Use, subject
to the terms and conditions for supply of Interferon Gamma 1-B set forth in the Supply Agreement, the payments set forth in Sections 8.2 through 8.8 below inclusive and all other applicable obligations of
Connetics under this Agreement. 
 (b)       Connetics may request an expansion of the Field of Use in
the Territory, by providing Genentech with a written letter of intent which incorporates the terms and conditions specified in the Supply Agreement and Sections 8.2 through 8.8 of this Agreement and sets forth a detailed clinical development plan
and reasonable proposed timeline (through FDA clearance) for developing the additional medical indication(s) sought. Such letter of intent shall be deemed Confidential Information of Connetics. Upon receipt of such letter of intent, unless Genentech
is conducting research in, or developing, Interferon Gamma for such specified use, is already engaged in negotiations with a third party for such specified use, or is prevented by prior written agreements to grant rights to such additional
indications to Connetics, Genentech shall negotiate exclusively in good faith with Connetics, 

  
 26. 

 
for a period of sixty (60) days on a one time basis only for each such new indication outside the Field of Use, to expand the Field of Use as proposed in the letter of intent on terms
substantially similar to those contained in this Agreement. If the Parties do not reach mutual written agreement with respect to such proposed expansion of the Field of Use within sixty (60) days, Genentech shall continue to have the right to
license its rights to such proposed additional indications for Interferon Gamma outside the Field of Use to third parties other than Connetics, provided that, for a period of six (6) months after the 60 day exclusive negotiation period with
Connetics, the milestone fee and royalty terms offered by Genentech to third parties for such indications are not more favorable to such third parties than those in the final offer made by Connetics. 

(c)       Prior to offering any third party an opportunity to obtain any right or license under Genentech
Patent Rights, Genentech Knowhow, or Biogen License Rights to use, sell, offer for sale or import Licensed Products for any indication outside the Field of Use in the Territory, Genentech shall first offer to Connetics to expand the Field of Use to
include such indication, in accordance with Section 3.8(d) below. Such obligation to first offer to Connetics such indication outside the Field of Use shall apply only to the first time Genentech wishes to offer rights to another party to such
indication outside the Field of Use. 
 (d)       Genentech may offer to expand the Field of Use by
written notice to Connetics (“Offer Notice”). Upon receipt of such Offer Notice, Connetics shall have thirty (30) days to provide Genentech with a written letter of intent which incorporates the terms and conditions specified in the
Supply Agreement and Sections 8.2 through 8.8 of this Agreement. Upon receipt of such letter of intent, Genentech shall negotiate exclusively in good faith with Connetics, for a period of thirty (30) days on a one time basis only for each

  
 27. 

 
such new indication outside the Field of Use, to expand the Field of Use as proposed in the letter of intent on terms substantially similar to those contained in this Agreement. If the Parties do
not reach mutual written agreement with respect to such proposed expansion of the Field of Use within 30 days, Genentech shall continue to have the right to license its rights to such proposed additional indications for Interferon Gamma outside the
Field of Use to third parties other than Connetics. To remain under consideration as a potential licensee for such rights to Interferon Gamma outside the Field of Use, within ninety (90) days of receipt of Genentech’s Offer Notice,
Connetics shall provide Genentech with a detailed written clinical development plan and reasonable proposed timeline for developing (through FDA clearance) the additional medical indication(s) sought, which development plan shall be deemed the
Confidential Information of Connetics. 
  

	4.0	Supply of Interferon Gamma-1B 

4.1        Bulk Product and Finished Product. Genentech shall supply Connetics with, and Connetics
shall purchase, Bulk Product for clinical studies and for sales of Licensed Product and Finished Product for commercial sale of Licensed Product to treat CGD and osteopetrosis and for clinical studies, pursuant to the terms and conditions of the
Supply Agreement. 
 4.2        Supply of Non-human
Interferon Gamma. Upon Connetics’ reasonable request and in Genentech’s sole discretion, Genentech may choose to sell to Connetics Non-human Interferon Gamma at a price equal to [...***...].
Notwithstanding the foregoing, Genentech shall have no obligation to (a) provide any minimum amount of Non-human Interferon 

  
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***Confidential Treatment Requested 

 
Gamma to Connetics or (b) produce additional amounts of Non-human Gamma Interferon in the event its current inventory is depleted. 

 

	5.0	Intellectual Property Rights 

5.1         Ownership. Genentech shall retain title to Genentech Patent Rights, Genentech Knowhow,
Genentech Manufacturing Knowhow, the ACTIMMUNE mark, and to any patent rights and knowhow related to Interferon Gamma or Licensed Products developed solely by Genentech. Connetics shall retain title to Connetics Patent Rights and Connetics Knowhow
and to any patent rights and knowhow related to Interferon Gamma and Licensed Products developed solely by Connetics. Except as expressly provided herein, each Party shall own and shall have the exclusive right to exploit all intellectual property
rights owned or acquired by such Party. 
 5.2         Patent Prosecution and License Fees 

(a)       With the exception of Genentech Patent Rights under the [...***...] License, Genentech
shall be responsible for the prosecution and maintenance of the Genentech Patent Rights in the Territory at Genentech’s expense, in consultation with Connetics. Genentech shall be responsible for the prosecution and maintenance and outside
counsel fees associated therewith of the Genentech Patent Rights under the [...***...] License in the Field of Use in the Territory at Connetics’ expense, upon prior consultation with and approval from Connetics, which approval shall not
be unreasonably withheld or delayed. Genentech shall keep Connetics promptly informed of the status of prosecution of Genentech Patent Rights in the Territory, including providing copies of all material correspondence with the U.S. Patent and
Trademark Office. Connetics shall have the right to comment upon such 

  
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***Confidential Treatment Requested 

 
prosecution and Genentech agrees to take such comments into consideration reasonably in advance of any action taken by Genentech in such prosecution. 

(b)       Connetics shall assist Genentech in prosecuting and maintaining the Genentech Patent Rights as
contemplated by Section 5.2(a) above. 
 (c)       At least thirty (30) days prior to the time each
benchmark payment of [...***...] under the [...***...] License becomes due during the term of this Agreement, Genentech shall notify Connetics of such payment due and Connetics shall have the option of paying such benchmark payment, on
Genentech’s behalf, when due to [...***...]. In the event that Connetics chooses not to pay the benchmark payment when due, Connetics shall so notify Genentech and Genentech shall have the option of paying such benchmark payment. If
Genentech pays such benchmark payment, Connetics shall reimburse Genentech for such payment within thirty (30) days of receipt of Genentech’s request for reimbursement. 

5.3         Patent Infringement 

(a)       If either Party learns that a third party is infringing Genentech Patent Rights or Connetics
Patent Rights, it shall promptly notify the other in writing. The Parties shall use reasonable efforts in cooperation with each other to stop such patent infringement without litigation. 

(b)       Genentech and Connetics each shall have the first opportunity to take the appropriate steps to
remove the infringement of its own Patent Rights which claim Interferon Gamma and/or its manufacture or use in the Field of Use including, without limitation, initiating suit. In either case, if such Party decides not to take such steps with respect
to its own Patent Rights within one hundred twenty (120) days of discovering or being notified of the infringement, the other Party may do so. Each of the Parties agrees to 

  
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***Confidential Treatment Requested 

 
provide reasonable assistance to the other in taking such steps. Any legal action taken under this section will be at the expense of the Party by whom suit is filed and will be controlled by the
Party bringing suit. The Party not bringing suit may choose to be represented in any such action by counsel of its own choice at its own expense. The Party bringing suit shall be reimbursed for its costs associated with bringing suit with the
proceeds of any damages or costs recovered. Any monies remaining shall be split between the Parties on an equitable basis proportional to their respective damage from the infringement. If both Parties bring suit, equitable apportionment of the costs
and damages to be recovered shall be agreed upon before the filing of the suit. 

5.4         Third Party Rights. If a notice of infringement is received by, or a suit is initiated
against, either of Connetics or Genentech with respect to Licensed Products or the ACTIMMUNE mark, the Parties will in good faith discuss the best way to respond. 

5.5         Trademark Infringement 

(a)       If either Party learns that a third party is infringing the ACTIMMUNE mark, it shall promptly
notify the other in writing. The Parties shall use reasonable efforts in cooperation with each other to stop such trademark infringement without litigation. 

(b)       Genentech shall have the first opportunity to take the appropriate steps to remove the
infringement of the ACTIMMUNE mark, including, without limitation, initiating suit. If Genentech decides not to take such steps within one hundred twenty (120) days of discovering or being notified of the infringement, Connetics may do so. Each
of the Parties agrees to provide reasonable assistance to the other in taking such steps. Any legal action taken under this section will be at the expense of the Party by whom suit is filed and will be controlled by the Party bringing suit. The
Party not bringing suit may choose to be 

  
 31. 

 
represented in any such action by counsel of its own choice at its own expense. The Party bringing suit shall be reimbursed for its costs associated with bringing suit with the proceeds of any
damages or costs recovered. Any monies remaining shall be split between the Parties on an equitable basis proportional to their respective damage from the infringement. If both Parties bring suit, equitable apportionment of the costs and damages to
be recovered shall be agreed upon before the filing of the suit. 

5.6         [...***...] License. If Genentech receives notice that it has acquired any
Genentech Patent Rights under the [...***...] License after the Effective Date of this Agreement, Genentech shall notify Connetics in writing of such additional rights as soon as reasonable after Genentech receives such notice. 

 

	6.0	Product Promotion 

 6.1         Promotion.
Genentech agrees, and shall require its sublicensees, if any, to agree, not to promote Interferon Gamma or a Licensed Product in the Field of Use in the Territory. Connetics agrees, and shall require its sublicensees to agree, not to promote
Interferon Gamma or a Licensed Product outside the Field of Use or outside the Territory. 

6.2         Encroachment. In the event that either Party becomes aware of spillover sales of
Interferon Gamma by Genentech that is used within the Field of Use or of Licensed Product by Connetics that is used outside the Field of Use, the Parties, shall meet and agree in good faith on reasonably appropriate steps (a) to abate such
encroachment and (b) to compensate the Party which has suffered encroachment in its field of use by such spillover sales. 

  
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***Confidential Treatment Requested 

	7.0	Confidentiality 

 In the course of performance of this Agreement, one Party may disclose
to the other or receive information from the other relating to the subject matter of this Agreement which information shall be considered to be the disclosing Party’s confidential. information, if in the case of a written disclosure, it is
designated as confidential at the time of disclosure, or if in the case of oral disclosure, the specific nature of the oral disclosure and its confidentiality is confirmed in writing to the other Party within thirty (30) days of the oral
disclosure (the “Confidential Information”). Each Party shall protect and keep confidential and shall not use, publish or otherwise disclose to any third party, except as permitted by this Agreement or with the other Party’s written
consent, the other Party’s Confidential Information for a period of five (5) years from the date of termination of this Agreement if it is terminated at any time within five (5) years after the Effective Date of this Agreement,
otherwise for a period of three (3) years from date of termination or expiration of this Agreement. A Party may disclose the other Party’s Confidential Information to its sublicensees hereunder, provided that such sublicensees are subject
to obligations of confidentiality at least equivalent to those set forth in this Article 7. The Parties shall consult prior to the submission of any manuscript for publication to determine if the publication will contain any Confidential Information
of the other Party. Such consultation shall include providing a copy of the proposed manuscript to the other Party at least forty-five (45) days prior to the proposed date of submission to a publisher, incorporating appropriate changes proposed
by the other Party into the manuscript submission and deleting all of the other Party’s Confidential Information which such Party does not agree to the publication thereof. The foregoing notwithstanding, Confidential Information may be
disclosed: (a) during any 

  
 33. 

 
official proceeding before a court or governmental agency if reasonably related to that proceeding; (b) as a part of a patent application filed on inventions made under this Agreement,
provided that the Party whose Confidential Information is included in such application shall have the opportunity to review such disclosure at least fifteen (15) business days prior to the date of such filing and such Party does not object to
such disclosure; and (c) as may be reasonably required to comply with applicable governmental laws or regulations. For the purposes of this Agreement, Confidential Information shall not include such information that: 

 

	 	(i)	was known to the receiving Party at the time of disclosure; 

  

	 	(ii)	was generally available to the public or was otherwise part of the public domain at the time of disclosure or became generally available to the public or otherwise part of the public domain after disclosure other than
through any act or omission of the receiving Party in breach of this Agreement; 

  

	 	(iii)	became known to the receiving Party after disclosure from a source that had a lawful right to disclose such information to others; or 

 

	 	(iv)	was independently developed by the receiving Party without the use of Confidential Information of the other Party, as evidenced by written records. 

If Connetics sublicenses any of its rights hereunder to InterMune pursuant to this Agreement, Genentech and InterMune shall enter into a mutual confidentiality
agreement, substantially in the form of this Article 7.0, to protect confidential information that may be disclosed by InterMune to Genentech. 

  
 34. 

	8.0	Up-front Payment, Milestone Payments and Royalties 

In consideration for the licenses granted to Connetics by Genentech pursuant to Section 2.0 above, Connetics shall make the following
payments to Genentech: 
 8.1       Up-front Payment. Connetics
shall issue to Genentech upon the Original Closing Date (as defined in the Stock Agreement) shares of Connetics Common Stock (“Original Issuance Shares” as defined in the Stock Agreement) with a fair market value equal to two million
dollars ($2,000,000), on the terms and conditions set forth in the Stock Agreement. If, on the Second Closing Date (as defined in the Stock Agreement), the aggregate market value of the Original Issuance Shares (based on the Second Issuance Price
(as defined in the Stock Agreement)) is less than four million dollars ($4,000,000), Connetics shall issue to Genentech upon the Second Closing Date the number of additional shares of Connetics Common Stock (the °Second Issuance Shares,” as
defined in the Stock Agreement) equal to the lesser of: (i) the number of shares necessary to increase the aggregate market value of the Original Issuance Shares (based on the Second Issuance Price) plus the Second Issuance Shares (based on the
Second Issuance Price) to four million dollars ($4,000,000) or (ii) the number of shares necessary to increase the aggregate number of the Company’s shares of Common Stock held by Genentech (exclusive of any shares that Genentech has
purchased from parties other than the Company) to 9.9% of the Company’s total outstanding shares of Common Stock as of the close of business on the third trading day before the Second Closing Date, on the terms and conditions set forth in the
Stock Agreement. In lieu of all or any portion of the Second Issuance Shares that the Company is obligated to issue to Genentech on the Second Closing Date, the Company may elect to pay 

  
 35. 

 
Genentech the cash value of such Second Issuance Shares (based on the Second Issuance Price). The Original Closing and the Second Closing of the stock issuances shall take place as described in
the Stock Agreement. In the event that Connetics does not issue to Genentech all of the Second Issuance Shares or the cash value of the Second Issuance Shares, Genentech may, in addition to other remedies available to it by law or in equity,
immediately terminate this Agreement and the licenses granted to Connetics hereunder. Such termination by Genentech of the Agreement and the licenses hereunder does not discharge Connetics’ obligation to issue all of the Second Issuance Shares
or to pay to Genentech the cash value of the Second Issuance Shares. The up-front payment shall not be creditable against any royalty payments owed by Connetics under Sections 8.3 and 8.4 below. 

8.2         Milestone Payments for Licensed Products. Connetics shall make the following cash
milestone payments to Genentech: 
 (a)       [...***...] within thirty (30) days following
the dates on which each of the first three (3) NDA’s or BLA’s for a Licensed Product is filed with the FDA by Connetics for a new indication in the Field of Use; provided however, that such milestone payments shall not be paid upon
the filing of a NDA or BLA for an osteopetrosis or atypical mycobacterial infection indication. 

(b)       [...***...] within thirty (30) days following the date Connetics receives FDA
clearance of each new indication for a Licensed Product for commercial sale in the United States; provided however, that such milestone payment shall not be paid upon receipt of FDA clearance for an osteopetrosis or atypical mycobacterial infection
indication. 

  
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 (c)       [...***...] within thirty (30) days
following the first date Connetics’ aggregate Net Sales of all Licensed Products in the Territory exceed [...***...] in any calendar year. 

(d)       [...***...] within thirty (30) days following the first date Connetics’ aggregate
Net Sales of all Licensed Products in the Territory exceed [...***...] in any calendar year. 
 Notwithstanding the foregoing, upon the
expiration or revocation of the last remaining issued patent within the Genentech Patent Rights during the term of this Agreement, each of the milestones payments set forth in (a)-(d) above thereafter shall be reduced by fifty percent (50%).
Milestone payments shall not be creditable against any royalty payments owed under Sections 8.3 and 8.4 below. 

8.3         Royalties. Connetics shall pay Genentech the following royalties on Net Sales of
Licensed Products by Connetics and its sublicensees: 
 (a)       For annual aggregate Net Sales of all
Licensed Products in the Territory of up to three million seven hundred thousand dollars ($3,700,000), a royalty rate equal to 45% of such Net Sales. 

(b)       In addition to the payment of the royalty rate specified in (a) above, for annual aggregate
Net Sales of all Licensed Products in the Territory exceeding three million seven hundred thousand dollars ($3,700,000), a royalty rate equal to [...***...] of such Net Sales exceeding $3,700,000. 

(c)       The above royalties shall be payable until the later of: (i) the expiration or revocation of
the last remaining issued patent within the Genentech Patent Rights or (ii) twenty (20) years from the Effective Date of this Agreement. Notwithstanding the 

  
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foregoing, upon the expiration of the last to expire issued patent within the Genentech Patent Rights during the term of this Agreement, thereafter each of the royalty rates set forth in
(a) and (b) above shall be reduced by fifty percent (50%). 
 8.4       Third-Party Royalties. If
Genentech or Connetics is required to pay any third party a royalty due to the manufacture, use, sale, offer for sale or importation of a Licensed Product in the Territory for or by Connetics or its sublicensees, Connetics shall be responsible for
the payment of [...***...] of such third-party royalty, provided however, that Connetics may deduct from the royalties payable to Genentech under Section 8.3 above [...***...] of such third party royalties incurred only due to use
patents in the Field of Use in the Territory, up to a maximum total deduction of [...***...] percentage points from the royalties payable by Connetics to Genentech under Section 8.3. For purposes of clarification, such deductions shall
not apply to any benchmark payment under the [...***...] License made by Connetics pursuant to Section 5.2(c) above. Attached hereto as Exhibit G is a list of all such royalty obligations to third parties known to Genentech as of the Effective
Date without diligent search. No later than thirty (30) days from the Effective Date, Genentech shall complete a reasonable internal investigation of its records and update Exhibit G, as necessary, to accurately reflect all such royalty
obligations to third parties to the best of Genentech’s knowledge; provided however, Connetics acknowledges that Genentech has no obligation to conduct due diligence or any investigation with respect to third party patent rights related to
Licensed Products. Genentech shall notify Connetics in writing during the term of this Agreement if it becomes aware of any additional Genentech third party royalty obligations. 

  
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 8.5         Royalty Payments. Royalty payments shall
be made to Genentech quarterly within ninety (90) days following the end of each calendar quarter for which royalties are due. Each royalty payment shall be accompanied by a report summarizing the total Net Sales during the relevant three-month
period, and the calculation of royalties, if any, due thereon pursuant to Section 8.3. 

8.6         Taxes. Genentech shall pay any and all taxes levied on account of, or measured by, any
payment, including, without limitation, royalties, it receives under this Agreement. 

8.7         Termination. If the license granted to Connetics herein is terminated by the Parties,
Connetics shall have no obligation to make any milestone or royalty payments to Genentech that has not accrued prior to the effective date of such termination, but shall remain liable for all such payments accruing prior to termination. 

8.8         Records and Reporting Records. 

(a)       Connetics and any sublicensee of Connetics shall keep full, true and accurate books of account
containing all particulars which may be necessary for the purpose of showing Net Sales. Said books of account shall be kept at the principal place of business of Connetics or its sublicensee, as the case may be. Said books and the supporting data
shall be open at all reasonable times, for three (3) years following the end of the calendar year to which they pertain (and access shall not be denied thereafter, if reasonably available), to the inspection of an independent public accountant
retained by Genentech and reasonably acceptable to Connetics (or its sublicensee) for the purpose of verifying Net Sales under this Agreement; subject to the provisions of Section 8.8(c) below. 

  
 39. 

 (b)       Reports. Connetics shall within ninety
(90) days after the end of each calendar quarter beginning with the quarter of the first commercial sale of Licensed Product in the Field of Use in the Territory by Connetics or its sublicensee, deliver to Genentech a true and accurate report,
setting forth such particulars of the business conducted by Connetics and its sublicensees during the preceding quarter as are pertinent to an accounting for Net Sales and deductible expenses under this Agreement. Such reports shall include at least
the following: (i) the total gross sales of Licensed Products occurring during that calendar quarter, (ii) the allowable deductions therefrom, (iii) the total Net Sales of Licensed Products occurring during that calendar quarter and
(iv) the calculation of royalties, if any, due thereon pursuant to the above Section 8.3. 

(c)       Auditing. At Genentech’s request and expense, Connetics shall permit a certified public
accountant selected by Genentech and acceptable to Connetics to examine, not more than once in any four consecutive calendar quarters during the term of this Agreement, but including one (1) post-termination audit, Connetics’ books of
account and records of all sales of Licensed Products by Connetics for the sole purpose of determining the correctness of the reports provided by Connetics under the above Section 8.8(b). If such accountant reasonably determines that the
royalties owed by Connetics to Genentech under the above Section 8.3 have been, for any calendar year in total, understated by Connetics, Connetics shall immediately pay all understated royalties, together with interest on such royalties from
the date accrued at a rate of [...***...] and shall pay the reasonable costs of the examination if Connetics has understated such royalties by more than [...***...]. 

  
 40. 

***Confidential Treatment Requested 

	9.0	Representations and Warranties 

9.1         Disclaimer. Except as expressly provided herein, the Parties disclaim all other
representations and warranties, express or implied, including without limitation, WARRANTIES OF COMMERCIAL UTILITY, MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, VALIDITY OR SCOPE OF GENENTECH PATENT RIGHTS or
NON-INFRINGEMENT OF THIRD PARTY INTELLECTUAL PROPERTY RIGHTS. 

9.2         Representations and Warranties. 

(a)    Each party represents and warrants to the other that: (a) it is free to enter into this Agreement; (b) in
so doing it will not violate any other agreement to which it is a party; (c) it is currently capable of making the grant of rights described in Sections 2.1(a), (b), (c), (d), 2.2 and 2.4; and (d) it will not enter into any agreement in
the future which conflicts with or violates any term or provision of this Agreement. Genentech makes no representation or warranty that all intellectual property rights necessary for Connetics to make, have made, use, sell, offer for sale and import
Licensed Products in the Field of Use in the Territory have been granted to Connetics under Section 2.0 of this Agreement. 

(b)    Connetics further represents and warrants that, prior to the Effective Date of this Agreement, Connetics’
officers (acting under delegated authority of its Board of Directors) have determined that the fair market value of the exclusive license granted to Connetics hereunder is less than $15,000,000 and therefore that the execution and delivery of this
exclusive license Agreement, or the performance .of the obligations by Genentech or Connetics hereunder, do not require that filings be made under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, or under the rules or
regulations promulgated 

  
 41. 

 
thereunder, by Connetics, Genentech, or their respective affiliates or ultimate parent entities, if any. 

(c)    Genentech represents and warrants to Connetics that as of the Effective Date: (i) to Genentech’s
knowledge, it has not received any notice of a claim by a third party for infringement of such third party’s intellectual property relating to the use and practice of the Genentech Knowhow, the Genentech Manufacturing Knowhow, the Genentech
Patent Rights or the Biogen License Rights; and (ii) to the knowledge of Genentech’s patent counsel, there is no issued patent that would be infringed by the practice of the Genentech Knowhow, the Genentech Manufacturing Knowhow or the
Genentech Patent Rights as permitted under the license rights granted under Section 2.1; and (iii) it has no knowledge of any actual infringement by any third party in the Field of Use in the Territory of the Genentech Patent Rights. 

 

	10.0	Liability 

 10.1        Limitation of Liability.
Neither Party shall be liable to the other for indirect, incidental, special or consequential damages arising out of any of the terms or conditions of this Agreement or with respect to their performance or lack thereof. 

10.2        Connetics Indemnification. Connetics shall indemnify, defend and hold harmless Genentech
and its affiliates from and against all third party costs, claims, suits, expenses (including reasonable attorneys’ fees) and damages arising out of or resulting from: (a) any willful or negligent act or omission by Connetics relating to
the subject matter of this Agreement or (b) the use by or administration to any person of a Licensed Product, Bulk Product or Finished Product that was sold, distributed or otherwise provided to a third party by Connetics or its sublicensees
under this Agreement; except where such costs, claims, suits, expenses or damages arose or resulted from any negligent act or omission by 

  
 42. 

 
Genentech or any defect in the manufacture of Bulk Product or Finished Product by Genentech that was not discovered by Connetics, provided that Genentech gives reasonable notice to Connetics of
any such claim or action, tenders the defense of such claim or action to Connetics and assists Connetics at Connetics’ expense in defending such claim or action and does not compromise or settle such claim or action without Connetics’
prior written consent. 
 10.3     Genentech Indemnification. Genentech shall indemnify, defend and hold harmless
Connetics, its affiliates and sublicensees from and against all third party costs, claims, suits, expenses (including reasonable attorney’s fees) and damages arising out of or resulting from: (a) any willful or negligent act or omission by
Genentech relating to the subject matter of this Agreement; (b) any defect in the manufacture of Bulk Product or Finished Product by Genentech that was not discovered by Connetics; or (c) the use by or administration to any person of a
product containing Interferon Gamma sold, distributed or otherwise provided to a third party by Genentech or its sublicensees; except where the foregoing costs, claims, suits, expenses or damages arose or resulted from (i) any negligent act or
omission by Connetics or (ii) the use by or administration to any person of a Licensed Product sold, distributed or otherwise provided by Connetics or its sublicensees other than resulting from a defect in the manufacture of such Licensed
Product by Genentech, provided that Connetics gives reasonable notice to Genentech of any such claims or action, tenders the defense of such claim or action to Genentech and assists Genentech at Genentech’s expense in defending such claim or
action and does not compromise or settle such claim or action without Genentech’s prior written consent. 
  

	11.0	Term and Termination 

  
 43. 

 11.1    Term. This Agreement shall commence on the Effective Date of this
Agreement and, unless terminated earlier, shall expire at the later to occur of (a) the expiration of the last to expire of any Genentech Patent Rights or (b) twenty (20) years from the Effective Date of this Agreement; provided, however,
that in the event that either the [...***...] License or the Biogen License is terminated, the licenses granted by Genentech to Connetics under the [...***...] License or the Biogen License shall also terminate. Genentech shall use its
Best Efforts to keep the [...***...] License and the Biogen License in effect during the term of this Agreement, provided, however, that if Connetics declines to pay a [...***...] benchmark payment as outlined in Section 5.2(c) or pay
any royalty owed to [...***...] under the [...***...] License for the sales of Licensed Products, then Genentech shall not be obligated to make such payment and Genentech shall have the option, in its sole discretion, to terminate the
[...***...] License. One year before the expiration of this Agreement under this Section 11.1, the Parties agree to meet and to discuss in good faith extending the term of this Agreement on terms mutually agreeable to the Parties. 

11.2    Termination for Default. If either Party shall default in a material manner with respect to any material provision
of this Agreement and the other Party shall have given the defaulting Party written notice of such default, the defaulting Party shall have thirty (30) days to cure such default. If such default is not cured within such thirty (30) day
period, the non-defaulting Party shall have the right, upon notice to the defaulting Party and without prejudice to any other rights the non-defaulting Party may have,
to terminate this Agreement unless the defaulting Party is in the process of attempting in good faith to remedy such default, in which case, the thirty (30) day cure period shall be extended by an additional thirty (30) days. If Genentech
terminates this Agreement pursuant to this Section 11.2, 

  
 44. 

***Confidential Treatment Requested 

 
Genentech shall automatically have all of the rights set forth in Sections 11.3(a) and (b) of this Agreement. Upon such termination, any sublicenses granted under this Agreement shall not
automatically terminate, but instead, Genentech shall have the option to either terminate or continue this Agreement with each sublicensee. If Connetics terminates this agreement pursuant to this Section 11.2, Connetics shall automatically have
all of the rights set forth in Section 11.4 of this Agreement. Connetics shall have no right to terminate this Agreement pursuant to this Section 11.2 in the event of Genentech’s failure to supply Bulk Product or Finished Product. In
the event of Genentech’s failure to supply Bulk Product or Finished Product, Connetics shall have the rights set forth in the Supply Agreement. 

11.3 Genentech’s Rights on Termination 

(a)    If Genentech terminates this Agreement pursuant to Section 11.2 above, Genentech shall be automatically
granted a nonexclusive, sublicenseable, license in the Territory under Connetics Patent Rights and Connetics Knowhow arising from the efforts made by Connetics and its sublicensees hereunder in the research and development of Licensed Products, to
make, have made, use, sell, offer for sale or import Licensed Products and shall be automatically granted a right to use all of Connetics’ regulatory submissions made by or on behalf of Connetics for Interferon Gamma and Licensed Products. If
Genentech sells a commercial product under the license granted in this Section 11.3 that would, but for the license granted herein, infringe a claim of such Connetics Patent Rights or that is based upon, incorporates or utilizes such Connetics
Knowhow, Genentech shall pay Connetics a royalty, under terms and conditions to be mutually agreed upon by the Parties, such royalty to be commensurate with the value contributed by such Connetics Patent Rights and Connetics Knowhow to such
commercial product, but in no event shall such royalty 

  
 45. 

 
exceed two percent (2%) of Genentech’s net sales of such commercial product. As used herein, “net sales” shall have the equivalent definition given to Net Sales in
Section 1.25 above. 
 (b)    Upon the effective date of termination by Genentech pursuant to Section 11.2
above, Connetics shall promptly provide Genentech with copies of all related documentation regarding Connetics Patent Rights and Connetics Knowhow arising from the efforts made by Connetics and its sublicensees hereunder in the research, development
and manufacture of Licensed Products, whether written or electronic, and materials, including biological materials, in the form existing as of the effective date of such termination, reasonably necessary for Genentech to exercise its license rights
under Section 11.3(a) above. Such transfer shall be made in a timely and orderly fashion and in a manner such that the value of what is being transferred is preserved in all material respects. Connetics shall promptly take all appropriate and
necessary actions, including action before the involved regulatory agency, to effect transfer to Genentech of, and shall also permit Genentech to reference, any FDA submissions, including, without limitation, any PLA or BLA filed with the FDA with
respect to Licensed Products. Within ninety (90) days of such assignment and completion of all such appropriate and necessary actions, Genentech will reimburse Connetics for its actual expenses incurred in preparing documentation for filing or
referencing the submission and in taking such appropriate and necessary action related to such transfer or referencing. 

11.4    Connetics’ Rights on Termination. Should Connetics terminate this Agreement pursuant to Section 11.2
above, Genentech shall grant to Connetics (a) an exclusive, sublicenseable, royalty-bearing license, according to royalty terms described in 

  
 46. 

 
Sections 8.3 and 8.4 within the Field of Use in the Territory, under terms and conditions agreed upon by the Parties, under the Genentech Patent Rights and Genentech Knowhow in order to permit
Connetics to continue using, selling, offering for sale and importing Licensed Products in the Field of Use in the Territory (excluding, with respect to the fields of scleroderma and infectious disease or condition caused by human papillomavirus,
Licensed Products containing any form of Interferon Gamma other than Genentech Gamma Interferon D3, as that term is defined in the Biogen License), (b) a
non-exclusive, sublicenseable, royalty-bearing license, (conforming to the license grant in Section 2.1 (b) above) according to royalty terms described in Sections 8.3 and 8.4 in the Territory , under
terms and conditions agreed upon by the Parties, under the Genentech Patent Rights and Genentech Knowhow in order to permit Connetics to continue using, selling, offering for sale and importing Licensed Products containing any form of Interferon
Gamma other than Genentech Gamma Interferon D3 (as that term is defined in the Biogen License) in the Territory in the fields of scleroderma and infectious disease or condition caused by human
papillomavirus, (c) a non-exclusive, sublicenseable license (the royalty for which is already included in clause (a) above) in the Territory in the fields of scleroderma and infectious disease or
condition caused by human papillomavirus, under terms and conditions agreed upon by the Parties, under the Biogen License Rights in order to permit Connetics to continue using, selling, offering for sale and importing Licensed Products (except those
Licensed Products containing Biogen Gamma Interferon D0) in the field of scleroderma and infectious disease or condition caused by human papillomavirus in the Territory and (d) a non-exclusive sublicenseable license (the royalty for which is already included in clause (a) above) under Genentech Patent Rights and Genentech Manufacturing Knowhow in order to

  
 47. 

 
permit Connetics to continue making and having made Licensed Products in the Field of Use in the Territory. 

11.5    Bankruptcy. Either Party may, in addition to any other remedies available to it by law or in equity, terminate this
Agreement, in-whole or in part as the terminating Party may determine, by written notice to the other Party in the event the other Party shall have become bankrupt, or shall have made an assignment for the
benefit of its creditors or there shall have been appointed a trustee or receiver of the other Party or for all or a substantial part of its property or any case or proceeding shall have been commenced or other action taken by or against the other
Party in bankruptcy or seeking reorganization, liquidation, dissolution, winding-up, arrangement, composition or readjustment of its debts or any other relief under any bankruptcy, insolvency, reorganization
or other similar act or law of any jurisdiction now or hereafter in effect and any such event shall have continued for sixty (60) days undismissed, unbonded and undischarged. All rights and licenses granted under to this Agreement by one Party
to the other Party are, and shall otherwise be deemed to be, for purposes of Section 365 (n) of the Bankruptcy Code, licenses of rights to “intellectual property” as defined under Section 101 (56) of the Bankruptcy Code. The
Parties agree that the licensing Party under this Agreement shall retain and may fully exercise all of its rights and elections under the Bankruptcy Code in the event of a bankruptcy by the other Party. The Parties further agree that in the event of
the commencement of a bankruptcy proceeding by or against one Party under the Bankruptcy Code, the other Party shall be entitled to complete access to any such intellectual property pertaining to the rights granted in the licenses hereunder of the
Party by or against whom a bankruptcy proceeding has been commenced and all embodiments of such intellectual property. 

  
 48. 

 11.6        Unilateral Termination. In addition to any
other right of termination provided herein, Connetics shall have the right to terminate this Agreement for any reason, with or without cause upon six (6) months’ prior written notice to Genentech. If Connetics terminates this Agreement
pursuant to this Section 11.6, Connetics agrees that for the following three (3) years it will not use, sell or acquire from any third party (whether by license or otherwise) any Licensed Product in the Field of Use. If Connetics
terminates this Agreement pursuant to this Section 11.6, the licenses granted hereunder shall terminate and Genentech shall automatically have all of the rights set forth in Sections 11.3(a) and (b) of this Agreement. 

11.7        Survival of Certain Provisions. Termination of this Agreement for any reason shall not
release either Party from any obligation arising prior to the date of termination. The provisions of Sections 1.0, 2.4 (except in the event of termination of this Agreement by Connetics pursuant to Section 11.2), 11.3(a) and (b) (except in the
event of termination of this Agreement by Connetics pursuant to Section 11.2), 11.4 (except in the event of termination of this Agreement by Genentech pursuant to Section 11.2), and Articles 5.0, 7.0, 9.0, 10.0, 11.0 (except as provided in
this paragraph) and 12.0 shall survive any termination of this Agreement. 
  

	12.0	General Provisions 

 12.1        Notices. All
notices which may be required pursuant to this Agreement: (i) shall be in writing, (ii) shall he addressed, in the case of Genentech (except as otherwise specified herein), to the Corporate Secretary at the address set forth at the
beginning of this Agreement, and in the case of Connetics, to the Vice President - Intellectual Property at the 

  
 49. 

 
address set forth at the beginning of this Agreement, (or to such other person or address as either Party may so designate from time to time), (iii) shall be mailed, postage-prepaid, by
registered mail or certified mail, return receipt requested, or transmitted by courier for hand delivery or transmitted by facsimile and (iv) shall be deemed to have been given on the date of receipt if sent by mail or on the date of
delivery if transmitted by courier or facsimile. Notices by facsimile may be sent to the following numbers: for Connetics, to (650) 843-2899; for Genentech, to (650)
952-9881. 
 12.2     Governing Law. This Agreement shall be governed by and
construed in accordance with the laws of the state of California (other than its choice of law principles). 
 12.3
    Entire Agreement. This Agreement is the entire agreement between the Parties, and there are no prior written or oral promises or representations not incorporated herein or therein, except that certain Confidentiality
Agreement between the Parties dated January 9, 1997 which shall remain in full force and effect. This Agreement shall supersede and replace the Prior Agreement in its entirety, and the Prior Agreement shall be terminated automatically as of the
Effective Date. No amendment or modification of the terms of this Agreement shall be binding on either Party unless reduced to writing and signed by an authorized officer of the Party to be bound. 

12.4     Binding Effect and Assignment. This Agreement shall be binding upon and inure to the benefit of the Parties hereto
and their respective permitted successors and assigns. This Agreement shall not be assignable by either Party without the other’s prior written consent, provided however, that either Party may assign this Agreement, without the other
Party’s written consent but after providing thirty (30) days prior written notice to the other Party, to any successor pursuant to a consolidation or merger of such Party with or into 

  
 50. 

 
any other corporation or corporations that results in a change of greater than 50% of the voting control of such Party, or a sale, conveyance or disposition of all or substantially all of the
assets of such Party or the effectuation by such Party of a transaction or series of related transactions in which more than 50% of the voting power of such Party is disposed of. 

12.5    Waiver. The waiver by a Party hereto of any breach of or default under any of the provisions of this Agreement or
the failure of a Party to enforce any of the provisions of this Agreement or to exercise any right thereunder shall not be construed as a waiver of any other breach or default or as a waiver of any such rights or provisions hereunder. 

12.6    Severability. If any part of this Agreement shall be invalid or unenforceable under applicable law, such part shall
be ineffective only to the extent of such invalidity or unenforceability, without in any way affecting the remaining parts of this Agreement. In addition, the part that is ineffective shall be reformed in a mutually agreeable manner so as to as
nearly approximate the intent of the Parties as possible. 
 12.7    Publicity. Connetics and Genentech agree that,
except as may otherwise be required by applicable laws, regulations, rules, or orders, including the disclosure requirements of the Securities and Exchange Commission (“SEC”), no information concerning this Agreement and the transactions
contemplated herein (except information which is already in the public domain) shall be made public by either Party without the prior written consent of the other Party. Notwithstanding the foregoing, with respect to complying with the disclosure
requirements of the SEC; in connection with any required SEC filing of this Agreement by Connetics, Connetics shall seek confidential treatment of portions of this Agreement from the SEC and Genentech shall have the right to review and comment on
such an application for confidential treatment prior to its being filed with the SEC. Genentech 

  
 51. 

 
shall provide its comments, if any, on such application as soon as practicable and in no event later than seven (7) days after such application is provided to Genentech. To assist Connetics
in its compliance with SEC disclosure obligations, Genentech shall provide to Connetics, within fourteen (14) days of the Effective Date, electronic copies of this Agreement (and all exhibits hereto) and the Supply Agreement. In addition,
notwithstanding the foregoing, Connetics shall have the right to disclose information concerning this Agreement and the transactions contemplated herein to its legal representatives, advisors, prospective investors, investors, third party auditors,
sublicensees and prospective sublicensees hereunder to the extent reasonably necessary and under obligations of confidentiality no less stringent than those provided for in Article 7.0. 

12.8    Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original
for all purposes, but all of which together shall constitute one and the same instrument. 
 12.9    Force Majeure.
Neither Party shall be liable to the other for its delay or failure to perform under this Agreement or shall have any right to terminate this Agreement for any such delay or failure in performance attributable to any act of God, flood, fire,
explosion, strike, lockout, labor dispute, casualty or accident, war, revolution, civil commotion, act of public enemies, blockage or embargo, injunction, law, order, proclamation, regulation, ordinance, demand or requirement of any government or
subdivision, authority or representative of any such government, or any other cause beyond the reasonable control of such Party, if the Party affected shall give prompt notice of any such cause to the other Party. The Party giving such notice shall
thereupon be excused from such of its obligations, hereunder for the period of time that it is so disabled. 

  
 52. 

 12.10    Headings. Headings are for the convenience of reference only and
shall not control the construction or interpretation of any of the provisions of this Agreement. 
 12.11    No
Partnership. Nothing in this Agreement is intended or shall be deemed to constitute a partnership, agency, employer-employee, or joint venture relationship between the Parties. 

[Signature page follows] 

  
 53. 

 IN WITNESS WHEREOF, the Parties have caused this Agreement to be duly executed by its duly
authorized representatives as of the date set forth above. 
  

											
	 GENENTECH, INC.
	 		 	 CONNECTICS CORPORATION
	 	
						
	 By:
	 	 /s/Nicholas J. Simon
	 		 	 By:
	 	 /s/Thomas Wiggons
	 	
						
	 Name:
	 	 Nicholas J. Simon
	 		 	 Name:
	 	 Thomas Wiggons
	 	
						
	 Title:
	 	 Vice President, Business and

Corporate Development
	 		 	 Title:
	 	 President/CEO
	 	

  
 54. 

 Exhibit A 

Patent Applications and Patents Included in Genentech Patent Rights 

 

			
	U.S. Serial Number	  	U.S. Patent Number
	08/460,524	  	pending
	08/460,539	  	pending
	 	  	5,690,925
	 	  	5,582,824
	 	  	5,151,265
	 	  	5,200,177
	 	  	5,112,605
	 	  	5,196,191
	 	  	5,096,705
	 	  	5,574,137
	 	  	5,248,499

  
 55. 

 Exhibit B 

[...***...] 

  
 56. 

***Confidential Treatment Requested 

 Exhibit C 

[...***...] 

  
 57. 

***Confidential Treatment Requested 

 Exhibit D 

Third Party Sponsored Studies 

[...***...] 

  
 58. 

***Confidential Treatment Requested 

 Exhibit E 

Clinical Development Milestones 

[...***...] 

  
 59. 

***Confidential Treatment Requested 

 Exhibit F 

Clinical Reports 
 The following
information/reports will be provided to Genentech in a timely manner: 
  

	 	•	 	FDA Meeting Minutes 

	 	•	 	IND(s) 

	 	•	 	Initial 

	 	•	 	Updates (if applicable) 

	 	•	 	Annual Report(s) 

	 	•	 	Investigator Brochure(s) 

	 	•	 	Clinical Studies: 

	 	•	 	Protocol(s) 

	 	•	 	Prior to FDA Submission 

	 	•	 	First Patient-In (FPI) 

	 	•	 	First Patient-Out (FPO) 

	 	•	 	Last Patient-In (LPI) 

	 	•	 	Last Patient-Out (LPO) 

	 	•	 	Serious Adverse Event (SAE) Summary 

	 	•	 	Clinical Study Interim Analysis and Update(s) (if applicable) 

	 	•	 	Go/Non-Go Decision Minutes 

	 	•	 	Clinical Study Final Report(s) 

	 	•	 	Draft 

	 	•	 	Final Copy 

  
 60. 

 Exhibit G 

Third Party Royalties 
 Royalties are
payable under the [...***...] License, as follows (capitalized terms shall have the meanings defined in the [...***...] License): a [...***...] royalty is payable on Net Sales of gamma interferon in Approved Countries in the
Territory for the prophylaxis or treatment of atopic dermatitis and/or steroid-dependent asthma, where there is substantial protection from an issued Licensed Patent for the approved indication and where the Licensee has enjoyed Market Exclusivity.
The royalty rate is [...***...] on Net Sales in the Licensed Field in Approved Countries where the Licensee enjoyed Market Exclusivity but where there is no substantial patent protection, or while the Licensed Patent applications covering the
indication are still pending, provided that such applications have been diligently prepared, filed and maintained. The royalty rates described above are reduced by [...***...] for Approved Countries where the Licensee has not enjoyed Market
Exclusivity. 

  
 61. 

***Confidential Treatment Requested 

 Exhibit H 

TRANSFER DATE ACTIVITIES FOR COMMERCIAL 

SALES OF ACTIMMUNE FOR CGD 

Prior to the Transfer Date, as defined in Section 1.29 of this Agreement, the following activities must be completed by the appropriate
Party as described below: 
 I.       Regulatory Requirements 

1.       FDA License – Connetics must obtain all licenses, including license numbers, required for the
sale of Actimmune for CGD by Connetics. Connetics shall also obtain a NDC number. 
 2.       PLA/IND
Transfer – Genentech shall transfer to Connetics the PLA and IND for CGD on file with the FDA. 

3.       Connetics must obtain FDA review and approval, as required by law or regulation, for
Connetics’ labels, product insert and packaging for sale of Actimmune for CGD. 
 4.       Genentech
shall transfer its safety information to Connetics for Actimmune, as provided in Section 2.5(g) of this Agreement. Connetics shall establish a safety database system for Actimmune, such that as of the Transfer Date, Connetics shall be responsible
for all safety-related requirements under FDA regulations, including the reporting of adverse events. 

5.       Prior to the Transfer Date, Connetics shall establish all procedures, controls and other methods
and capabilities needed in order to comply with all requirements, laws and regulations applicable to the use, distribution and sale of Actimmune for CGD. 

II. Quality Control, Product Testing 

1.       To the extent that Connetics is required by law or regulation to conduct any quality control,
quality assurance and/or stability testing of Actimmune sold for CGD, in addition to any such testing to be conducted by Genentech pursuant to the Supply Agreement, Connetics shall establish procedures and obtain regulatory approval to do so prior
to the Transfer Date. 
 III.       Uninsured Patient Program 

Connetics shall have established an uninsured patient program, including procedures for determining patient eligibility. Genentech shall
transfer to Connetics its existing information regarding such patients prior to the Transfer Date, to the extent it has received consent from such patients to do so. Connetics shall notify Genentech prior to the Transfer Date which of the patients
participating in Genentech’s uninsured patient program, and for which Genentech has transferred information, shall receive drug under Connetics’ uninsured patient program. 

  
 62. 

 IV. Product Distribution and Sale 

1        Connetics shall establish product distribution and inventory systems for Actimmune. Genentech
will provide to Connetics the name of its current distributor. 
 2.        Connetics shall
establish systems and personnel required to address customer inquiries, medical information requests and product returns. 

  
 63.EX-10.65

 Exhibit 10.65 

***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 

and 240.24b-2. 

AMENDMENT NO. THREE 
 TO

 LICENSE AGREEMENT 

THIS AMENDMENT NUMBER THREE TO LICENSE AGREEMENT FOR INTERFERON GAMMA (“Amendment”) is entered into effective
April 27, 1999 (the “Amendment Effective Date”), by and between Genentech, Inc. (“Genentech”) and Connetics Corporation (“Connetics”). Genentech and Connetics may each be referred to herein as a “Party”
and jointly as the “Parties.” 
 RECITALS 
  

	A.	 The Parties have previously entered into that certain License Agreement for Interferon Gamma, dated
May 5, 1998, as amended on December 23, 1998 and on January 15, 1999 (the “License Agreement”). 

  

	B.	 Pursuant to Section 2.3(c) of the License Agreement, Connetics has the right to sublicense certain of its
rights under the Agreement to InterMune Pharmaceuticals, Inc. (“InterMune”), and has in fact entered into such sublicense to that effect dated August 21, 1998. 

 

	C.	 The Parties have entered into that certain letter agreement dated January 5, 1999 and revised on
March 1, 1999 (the “Letter Agreement”), documenting the intent and agreement of Connetics and Genentech with respect to certain additional rights to be granted to Connetics and its sublicensees under the Genentech License, pending the
preparation of an amendment to the License Agreement. 

  

	D.	 In consideration of such additional rights, InterMune will issue to Genentech shares of Genentech Series A-1 Preferred InterMune stock on the terms and conditions set forth in that certain stock purchase agreement between Genentech and InterMune of even date herewith. 

 

	E.	 The Parties now desire to enter into a definitive amendment to the License Agreement, as of the Amendment
Effective Date, through which Genentech shall grant, and Connetics and InterMune shall accept, such certain additional rights under the License Agreement. 

NOW, THEREFORE, in consideration of the foregoing and of the mutual
covenants and conditions herein contained, and intending to be legally bound hereby, the Parties mutually agree as follows: 
  

	1.	 Terms not otherwise defined in this Amendment shall have the meanings defined in the License Agreement.

  

	2.	 A new Section 1.7.1 is hereby added to read in its entirety as follows: 

 1.7.1 “Combination Product Adjustment” shall mean the
following: in the event that a Licensed Product is sold in the form of a combination product containing one or more active ingredients or components in addition to such Licensed Product, Net Sales for such combination product will be adjusted by
multiplying actual Net Sales of such combination product by the fraction A/(A + B) where A is the invoice price of the Licensed Product, if sold separately, and B is the invoice price of any other active ingredient(s) or component(s) in the
combination, if sold separately. If, on a country-by-country basis, the other active ingredient(s) or component(s) in the combination are not sold separately in said
country, Net Sales shall be calculated by multiplying actual Net Sales of such combination product by the fraction A/C where A is the invoice price of the Licensed Product if sold separately, and C is the invoice price of the combination product.
If, on a country-by-country basis, neither the Licensed Product nor the other active ingredient(s) or component(s) of the combination product is sold separately in said
country, Net Sales allocable to the Licensed Product shall be determined by mutual agreement reached in good faith by the Parties based on an equitable method of determining such Net Sales that, among other considerations, takes into account, on a country-by-country basis, variations in potency, the relative contribution of each active ingredient or component in the combination product and the relative value to the end-user of each active ingredient or component. 
  

	3.	 Section 1.12 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 1.12    “Field of Use” shall mean the administration to
humans of Licensed Protein Product for the treatment or prevention of any human disease or condition, [...***...]. Each “indication” listed on Exhibit E attached hereto shall be referred to herein individually as an “Area of the
Field of Use” and collectively as “Areas of the Field of Use.” 
  

	4.	 A new Section 1.15.1 is hereby added to the Agreement to read in its entirety as follows:

 1.15.1 “Gene Therapy Field of Use” shall mean the administration to humans of
Licensed Gene Product for Gene Therapy for the treatment or prevention of any human disease or condition, [...***...]. 
  

	5.	 Section 1.18 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 1.18    “Genentech Patent Rights” shall mean all patents
and patent applications and any patents issuing therefrom, together with any extensions, reissues, reexaminations, substitutions, renewals, divisions, continuations and continuations-in-part thereof: 

  
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 (a)    that are owned or controlled by
Genentech presently or hereafter, during the term of this Agreement, and under which Genentech is free to license or sublicense; and 

(b) to the extent they claim or directly relate to: (i) Interferon Gamma or the manufacture or use of
Interferon Gamma in the Field of Use, or (ii) IG Nucleotide Sequence or the manufacture or use of IG Nucleotide Sequence in the Gene Therapy Field of Use; 

including, without limitation, the patent rights granted under that certain license agreement between Genentech and
Children’s Medical Center Corporation, dated July 16, 1990 (the “CMCC License”), but specifically excluding any rights granted to Genentech under the Biogen License. Genentech Patent Rights shall include, without limitation, the
patents and patent applications listed in Exhibit A attached hereto. Notwithstanding the foregoing, Genentech Patent Rights shall exclude any rights Genentech acquires after the Effective Date under third-party license agreements, with the exception
of those rights acquired under the CMCC License, unless and until the Parties mutually agree on terms and conditions for the sublicense of such rights from Genentech to Connetics. 

 

	6.	 A new Section 1.20.1 of the License Agreement is hereby added to read in its entirety as follows:

 1.20.1    “IG Nucleotide Sequence” shall mean any DNA or
RNA sequence encoding Interferon Gamma. 
  

	7.	 Section  1.22 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 1.22 “Licensed Product” shall mean, collectively: 

(a)    Any pharmaceutical formulation containing Interferon Gamma, whether alone or
together with or incorporated into any other substance or product or material or device, whether active or not, and which (i) but for the licenses granted hereunder, the manufacture, use, sale, offer for sale or importation of which in the
Territory would infringe or contribute to the infringement of the Genentech Patent Rights in the Territory, or (ii) is based upon or incorporates or utilizes Genentech Knowhow (a “Licensed Protein Product”); and 

(b)    Any pharmaceutical formulation containing the IG Nucleotide Sequence, whether
alone or together with or incorporated into any other substance or product or material or device, whether active or not, and which but for the licenses granted hereunder, the manufacture, use, sale, offer for sale or importation of which in the
Territory would infringe or contribute to the infringement of the Genentech Patent Rights in the Territory (a “Licensed Gene Product”). 
  

	8.	 The following two sentences are hereby added to the end of Section 1.25: 

 [...***...], shall also be deducted from the gross invoiced
sales prices charged for such Licensed Products in determining Net Sales for such Licensed Products. In the event that a Licensed Product is sold in the form of a combination product containing one or more active ingredients or components in
addition to such Licensed Product, Net Sales for such combination product will be calculated in accordance with the Combination Product Adjustment.” 
  

	9.	 Section  1.28 of the License Agreement is hereby deleted and replaced in its entirely as follows:

 1.28 “Territory” shall mean the United States of America, and its territories
and possessions, and Japan. 
  

	10.	 A new Section 1.37 is hereby added to the License Agreement to read in its entirety as follows:

 1.37     “Third Party Product Rights” shall mean any
rights licensed or sublicensed to any third party by Genentech as of the Effective Date to use, manufacture or sell (a) Interferon Gamma, (b) the IG Nucleotide Sequence or (c) any pharmaceutical formulation containing either or both
of Interferon Gamma and the IG Nucleotide Sequence, whether alone or together with or incorporated into any other substance or product or material or device, whether active or not; [...***...]. 

 

	11.	 Section  2.1 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 2.1     Patent and Knowhow License Grants. 

(a) Genentech hereby grants to Connetics an exclusive license, even as to Genentech, under Genentech Patent
Rights and under Genentech Knowhow to use, sell, offer for sale and import (but not to make or have made) Licensed Protein Products in the Field of Use in the Territory (excluding Japan), (excluding, with respect to the fields
of    (i) scleroderma and (ii) infectious disease or condition caused by human papillomavirus, Licensed Protein Products containing any form of Interferon Gamma other than Genentech Gamma Interferon D3 (as that term is defined in the Biogen License)). Notwithstanding the foregoing, Genentech reserves the right to use (but not to import, offer for sale or sell) Licensed Protein Products within the Field of
Use solely for non-commercial research purposes. 

(b)       Genentech hereby grants to Connetics a non-exclusive license under Genentech Patent Rights and under Genentech Knowhow to use, sell, offer for sale and import (but not to make or have made) Licensed Protein Products containing any form of Interferon
Gamma other than Genentech Gamma 

  
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Interferon D3 (as that term is defined in the Biogen License) in the Territory (excluding Japan) in the fields of: (i) scleroderma and
(ii) infectious disease or condition caused by human papillomavirus. 

(c)       Genentech hereby grants to Connetics a non-exclusive sublicense under the Biogen License Rights to use, sell, offer for sale and import Licensed Protein Products (excluding Licensed Protein Products containing Biogen Gamma Interferon D0 (as that term is defined in the Biogen License)) in the Territory (excluding Japan) in the fields of scleroderma and infectious disease or condition caused by human papillomavirus. 

(d)       Genentech hereby grants to Connetics a non-exclusive license under Genentech Patent Rights to make or have made in the Territory (excluding Japan) Licensed Protein Products for use or sale in the Field of Use in the Territory (excluding Japan). 

(e)       Genentech hereby grants to Connetics a non-exclusive license under Genentech Patent Rights and Genentech Knowhow to use non-human animal species derived homologues of Interferon Gamma
(“Non-human Interferon Gamma”) solely for non-commercial research purposes to support the Field of Use in the Territory (excluding Japan). Genentech hereby
grants to Connetics a non-exclusive license under Genentech Patent Rights to use non-human animal species derived homologues of IG Nucleotide Sequence (“Non-human Interferon Gamma-encoding IG Nucleotide Sequence”) solely for non-commercial research purposes to support the Gene Therapy Field of Use in the Territory
(excluding Japan). 
 (f)       Genentech hereby grants to Connetics a co-exclusive license under Genentech Patent Rights to use, make, have made, import, offer for sale and sell Licensed Gene Products in the Gene Therapy Field of Use in the Territory (excluding Japan). Notwithstanding
the foregoing, Genentech reserves the right to use (but not to import, offer for sale or sell) Licensed Gene Products within the Gene Therapy Field of Use solely for non-commercial research purposes. As used
in this subsection (f), “co-exclusive” shall mean that (i) Genentech shall not grant a license to any party other than Connetics to use, make, have made, import, offer for sale or sell Licensed
Gene Products in the Gene Therapy Field in the Territory (excluding Japan) [...***...], and (ii) Genentech shall not authorize or approve any grant or assignment [...***...]. 

(g)       (i)     Genentech hereby grants to Connetics
an exclusive license, even as to Genentech, under Genentech Patent Rights and under Genentech Knowhow, in Japan to make, have made, use, sell, offer for sale and import [...***...] 

  
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 [...***...]. 

(ii)      Connetics, its Affiliates and sublicensees hereunder shall
[...***...], to the extent based, in whole or in part, [...***...] for indications (including, without limitation, the treatment of [...***...]. Connetics’ and its Affiliates’ and sublicensees’ [...***...]
shall terminate with respect to [...***...]. 
 (iii)      In the event
that any Third Party Product Rights held by a third party [...***...] revert to Genentech, then Genentech shall notify Connetics or its designated sublicensee in Japan of such reversion, and upon such notice Genentech shall be deemed to have
automatically granted to Connetics the license under Genentech Patent Rights and under Genentech Knowhow to all such reverted rights, which license shall be exclusive to the extent that such reverted rights were exclusive. All rights granted to
Connetics pursuant to this subsection (iii) shall be subject to the terms of this Agreement, including without limitation subsection (ii) above, Section 3.2(g) and Section 8.3. 

(h)      In the event that any Third Party Product Rights (other than those
described in subsection (g) above) shall revert to Genentech, then Genentech shall notify Connetics of such reversion. For the ninety (90) day period following its receipt of such notice, Genentech and Connetics shall negotiate exclusively
in good faith the reasonable commercial terms upon which Genentech would be willing to grant to Connetics the license to such reverted rights. If the Parties fail to enter a written agreement for a license to such rights by the end of such ninety
(90) day period, then Genentech shall have no further obligation to Connetics with respect to such rights; provided that for six (6) months following such ninety 

  
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(90) day period, Genentech shall not enter into an agreement to grant a license to such rights with a third party on terms that, taken as a whole, are less favorable to Genentech than those last
offered by Connetics for such rights. [...***...]. Nothing in the preceding sentence shall imply any [...***...]. Connetics may not transfer its rights under this Section 2.1(h) to any party other than InterMune without Genentech’s
prior written consent. 
 Except as expressly granted herein, there are no implied licenses under the Genentech Patent
Rights or any other intellectual property rights owned or controlled by Genentech. 
  

	12.	 Section 2.3(b) of the License Agreement is hereby deleted and replaced in its entirety as follows:

 (b)       Connetics may grant one or more
sublicenses under the rights granted in Sections 2.1(a), (b), (c), (e), (f) and (g) in the Field of Use and the Gene Therapy Field of Use, on thirty (30) days prior written notice to Genentech, and subject to Genentech’s prior written
approval, which approval shall not be unreasonably withheld. 
  

	13.	 A new Section 3.2(g) is hereby added to read in its entirely as follows: 

(g)       In addition to the Clinical Development Milestones (as set forth
in Exhibit E hereto), Connetics shall use its Best Efforts to develop and commercialize Licensed Products: (i) in the Field of Use with respect to indications and diseases that, under the provisions of this Amendment, have been added to the
“Field of Use” as defined in the original License Agreement executed as of May 5, 1998, and (ii) in the Gene Therapy Field of Use. Such additional indications and diseases in the Field of Use, and the Gene Therapy Field of Use,
collectively are referred to in this subsection (g) as the “Additional Indications.” In the event that Connetics is not conducting such development efforts with respect to any Additional Indication(s) in a country or countries in the
Territory as of the [...***...] (or if rights to such Additional Indication were granted to Connetics pursuant to Section 2.1(g)(iii), then as of the [...***...] that Genentech notifies Connetics or its designated sublicensee regarding
such rights as set forth in that Section) or at any time thereafter, Genentech shall have the right to terminate this Agreement, and the licenses granted hereunder, with respect to Licensed Products for such Additional Indication(s) in such country
or countries, upon [...***...] days prior written notice to Connetics, unless Connetics can reasonably 

  
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demonstrate, during such notice period, by its written records that as of the date of such notice it is conducting such development efforts with respect to such Additional Indication(s) in such
country or countries. 
  

	14.	 Sections 8.2(a) and (b) of the License Agreement are hereby deleted and replaced in their entirety as
follows: 

 (a)       [...***...] within thirty
(30) days following the dates on which the first NDA or BLA, as applicable, for a Licensed Protein Product is filed with the FDA by Connetics for [...***...]; provided however, that such milestone payments shall only be paid once for each
of the foregoing indications, and shall not be paid upon the filing of a NDA or BLA for an osteopetrosis or any mycobacterial infection indication. 

(b)       [...***...] within thirty (30) days following the date
Connetics receives the first FDA approval of [...***...]; provided however, that such milestone payment shall only be paid once for each of the foregoing indications, and shall not be paid upon receipt of FDA approval for commercial sale for
an osteopetrosis or any mycobacterial infection indication. 
  

	15.	 Section 8.3 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 8.3        Royalties. Connetics shall pay Genentech the
following royalties on Net Sales of Licensed Products by Connetics and its sublicensees: 

(a)       For annual aggregate Net Sales of all Licensed Protein Products
in the Territory (excluding Japan) of up to three million seven hundred thousand dollars ($3,700,000), a royalty rate equal to forty-five percent (45%) of such Net Sales. 

(b)       In addition to the payment of the royalty rate specified in
(a) above, for annual aggregate Net Sales of all Licensed Protein Products in the Territory (excluding Japan) exceeding three million seven hundred thousand dollars ($3,700,000), a royalty rate equal to ten percent (10%) of such Net Sales
exceeding $3,700,000. 
 (c)       For Net Sales of all Licensed Protein
Products in Japan, a royalty rate equal to [...***...] of such Net Sales; provided, however, that in the event that [...***...] for an indication for which InterMune has exclusive rights under Section 2.1(g), the foregoing royalty
rate shall be reduced to [...***...] for Net Sales of [...***...] in Japan for such indication [...***...] 

  
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 [...***...]. For the sake of clarity, Net Sales of Licensed Protein
Products to which Connetics acquires rights pursuant to Section 2.1(g)(iii) shall be subject to this subsection (c). 

(d)       (i)      For Net Sales of Licensed Gene
Product in the Territory, where such Licensed Gene Product is used in conjunction with a Licensed Protein Product for the treatment or prevention of a given indication in a given patient population, a royalty rate equal to [...***...] of such
Net Sales. As used in this subsection (d), “indication” shall mean any particular medical condition within the Field of Use and Gene Therapy Field of Use, including but not limited to labeling claims approved by a regulatory agency. 

(ii)       For Net Sales of Licensed Gene Product in a country in the
Territory, where such Licensed Gene Product is used in a given patient population for the treatment or prevention of the same indication for which a given Licensed Protein Product is used in such patient population, a royalty rate equal to (A)
[...***...] of such Net Sales during the [...***...] period following the first commercial sale of such Licensed Gene Product in such country for the treatment or prevention of such indication in such patient population by Connetics, or
its Affiliates and sublicensees (the “First Commercial Sale”); (B) [...***...] of such Net Sales during the [...***...] period following the First Commercial Sale; and (C) [...***...] of such Net Sales beginning on the
[...***...] anniversary of the First Commercial Sale and thereafter. 

(iii)       Notwithstanding the provisions of subsections (i) and
(ii) above, in the event that annual Net Sales of a Licensed Gene Product for the treatment or prevention of an indication in a patient population in a country in the Territory [...***...] for the treatment or prevention of such indication in
such patient population in such country, the royalty rate thereafter applicable to Net Sales of such Licensed Gene Product for the treatment or prevention of such indication in such patient population in such country shall be ten percent (10%) of
such Net Sales. 
 (iv)       In the event that Connetics or InterMune
determines at any point following [...***...] that the above royalty rates are having or are likely to have an adverse impact on Connetics’ or InterMune’s ability to compete effectively in its sales of such Licensed Gene Product,
Connetics or InterMune shall so notify Genentech, and the Parties shall in good faith discuss and attempt to reach a reasonable and mutually agreeable resolution to the situation. 

(e)           (i)      
  The royalties set forth in subsections (a), (b) and (c) above shall be payable, on a country-by-country basis, until the later of: (A) the
expiration or revocation of the last remaining issued patent in such country within the Genentech Patent Rights that covers Licensed Protein Products, or (B) [...***...] years from the Effective Date of this Agreement. Notwithstanding the 

  
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foregoing, upon the expiration of the last to expire issued patent in each country within the Genentech Patent Rights during the term of this Agreement, thereafter each of the royalty rates set
forth in (a), (b) and (c) above shall be reduced by [...***...] with respect to such country. 

(ii)       The royalties set forth in subsection (d) above shall be
payable, on a country-by-country basis, until the expiration or revocation of the last remaining issued patent in such country within the Genentech Patent Rights that
covers Licensed Gene Products. 
  

	16.	 Section  8.4 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 8.4         Third-Party Royalties. If
Genentech or Connetics is required to pay any third party a royalty due to the manufacture, use, sale, offer for sale or importation of a Licensed Product in the Territory for or by Connetics or its sublicensees, Connetics shall be responsible for
the payment of [...***...] of such third-party royalty, provided however, that Connetics may deduct from the royalties otherwise payable to Genentech under Section 8.3 above, an amount equal to [...***...] of such third party
royalties incurred only due to use patents in the Field of Use or in the Gene Therapy Field of Use in the Territory, provided that the amount deducted shall not exceed [...***...] of the royalties otherwise payable by Connetics to Genentech
under Section 8.3. For purposes of clarification, such deductions shall not apply to [...***...]. Attached hereto as Exhibit G is a list of all such royalty obligations to third parties known to Genentech as of the Effective Date without
diligent search. No later than thirty (30) days from the Effective Date, Genentech shall complete a reasonable internal investigation of its records and update Exhibit G, as necessary, to accurately reflect all such royalty obligations to third
parties to the best of Genentech’s knowledge; provided however, Connetics acknowledges that Genentech has no obligation to conduct due diligence or any investigation with respect to third party patent rights related to Licensed Products.
Genentech shall notify Connetics in writing during the term of this Agreement if it becomes aware of any additional Genentech third party royalty obligations. 
  

	17.	 Section  8.5 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 8.5         Royalty Payments. 

(a)          Royalty payments shall be made to Genentech
quarterly within ninety (90) days following the end of each calendar quarter for which royalties are due. Each royalty payment shall be accompanied by a report summarizing the total Net Sales during the relevant three-month period, and the
calculation of royalties, if any, due thereon pursuant to Section 8.3. 

  
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(b)        Notwithstanding subsection (a) above, any royalty
payments which accrue during 1999 on Net Sales of Licensed Protein Product sold by Connetics’ sublicensee InterMune shall be paid to Genentech in the form of promissory note, in the form attached hereto as Exhibit I. For each calendar quarter
in 1999 for which royalty payments are due, InterMune shall execute and deliver to Genentech, within ninety (90) days following the end of each such calendar quarter, a promissory note in the form of Exhibit I, and in the amount of such
royalties due to Genentech for such quarter. Each such promissory note shall be accompanied by the report described in Section 8.5(a) above for such quarter. In the event that any such note is delivered by InterMune after such 90 day period,
nevertheless interest shall accrue on the date that such note was due. 
  

	18.	 The following provision is hereby inserted as Section 10.4 to the License Agreement:

 10.4         Insurance. At all times
during the term of this Agreement, Connetics and its sublicensees shall provide the following insurance at its sole cost and expense: 

(a)       Commercial General Liability, including coverage for products
and completed operations (maintained for a period of at least [...***...] after the expiration or termination of this Agreement) [...***...]. The policy shall have a limit of no less than [...***...] dollars. 

(b)       Foreign Local Coverages: Where required by law, Connetics and
its sublicensees will purchase foreign local coverages in an amount that, at a minimum, satisfies the legal requirements of that jurisdiction. 

(c)       Policy Conditions: All policies under (a) and (b) above
shall: 
 (i)       be written by insurance companies with an A.M.
Best’s rating of A:VIII or higher (or if Connetics’ or its sublicensees policies are not subject to the Best rating, then by carriers who are acceptable to Genentech); and 

(ii)       add Genentech as an additional insured. 

(d)       Additionally, Connetics shall use its Best Efforts to obtain
from its insurance carrier for the policies described in subsections (a) and (b) covenants: 

(i)       [...***...]; and 

(ii)      [...***...]. 

Connetics and its sublicensees shall provide Genentech a certificate of insurance which shall reflect the
above coverages and provisions, with annual renewals as long as the contract continues. 

  
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	19.	 Section 11.1 of the License Agreement is hereby deleted and replaced in its entirety as follows:

 11.1    Term. This Agreement shall commence on the Effective Date of this Agreement
and, unless terminated earlier, shall expire: 
 (a)       With respect
to Licensed Protein Products, at the later to occur of (i) the expiration of the last to expire of any Genentech Patent Rights covering a Licensed Protein Product, or (ii) twenty (20) years from the Effective Date of this Agreement; and

 (b)       With respect to Licensed Gene Products, at the expiration of
the last to expire of any Genentech Patent Rights covering a Licensed Gene Product; 
 provided,
however, that in the event that either the CMCC License or the Biogen License is terminated, the licenses granted by Genentech to Connetics under the CMCC License or the Biogen License shall also terminate. Genentech shall use its Best Efforts
to keep the CMCC License and the Biogen License in effect during the term of this Agreement, [...***...]. One (1) year before the expiration of this Agreement under Section 11.1(a), the Parties agree to meet and to discuss in good faith
extending the term of this Agreement with respect to Licensed Protein Products on terms mutually agreeable to the Parties. 

20.        Exhibit E of the License Agreement is hereby deleted and replaced in its entirety
with new Exhibit E attached hereto and incorporated herein. 
 21.        In consideration
for the rights granted to Connetics and its sublicensees under this Amendment, InterMune shall issue to Genentech eight hundred seventy five thousand (875,000) shares of Series A-1 Preferred Stock
simultaneously herewith. 
 22.        This Amendment supersedes the Letter Agreement in its
entirety. All other terms and provisions of the License Agreement, including all exhibits to that Agreement, will continue in full force and effect as though fully set forth in this Amendment. Nothing in this Amendment shall be construed as
affecting Connetics’ obligations to be liable and responsible for the performance of all of the obligations of Connetics and its sublicensees under the License Agreement. 

THIS SPACE INTENTIONALLY LEFT BLANK 

  
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 IN WITNESS WHEREOF, the Parties have caused
this Amendment to be executed by the respective duly authorized officers as of the date first written above. 
  

			
	GENENTECH, INC.	 	CONNETICS CORPORATION
		
	By: /s/ Nicholas J.
Simon                                        
    	 	By: /s/ Thomas G.
Wiggans                                      

		
	Printed Name: Nicholas J.
Simon                                	 	Printed Name: Thomas G. Wiggans                          
		
	Title: Vice President,
Business                                    
   
       and Corporate Development	 	Title: President and Chief Executive Officer            

 Acknowledged and agreed as to InterMune’s rights and obligations hereunder as Connetics’ sublicensee under the
License Agreement: 
  

	
	 INTERMUNE PHARMACEUTICALS, INC.

	
	 By: /s/ Scott
Harkonen                             

	
	 Printed Name: Scott Harkonen, M.D.      

	
	 Title:
President                                       
  

 Exhibit E 

[...***...] 

  
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