Document:

Exhibit 10.1

 

FORM OF NOTE PURCHASE AGREEMENT

 

Protalix BioTherapeutics, Inc.

2 Snunit Street, Science Park, POB 455

Carmiel 20100, Israel

 

Ladies and Gentlemen:

 

This Note Purchase
Agreement (this “Agreement”) is made as of December 1, 2016, by and among Protalix BioTherapeutics, Inc., a
corporation organized under the laws of the State of Delaware (the “Company”), and each purchaser identified
on the signature pages hereof (each, including its successors and assigns, a “Purchaser” and collectively, the
“Purchasers”). Each Purchaser hereby confirms its agreement with you as follows:

 

		1.	The Company and such Purchaser is executing and delivering
this Note Purchase Agreement in reliance upon the exemption from securities registration afforded by Section 4(a)(2) of the Securities
Act of 1933, as amended (the “Securities Act”). Such Purchaser is a “qualified institutional buyer”
as defined in Rule 144A under the Securities Act.

 

		2.	Subject to the terms and conditions of this Note Purchase
Agreement, the Indenture (as defined below), the Security Agreement, dated as of the Closing Date (as defined in Section 1.1 of
ANNEX B hereto), among the Company, the guarantors party thereto and Wilmington Savings Fund Society, FSB, as Collateral Agent
(the “Collateral Agent”) (the “U.S. Security Agreement”), the Security Agreement/Debenture,
dated as of the Closing Date, between Protalix Ltd. and Altshuler Shaham Trusts Ltd., as Security Trustee (the “Israeli
Security Trustee”) (the “IP Charge”), the Security Agreement/Debenture, dated as of the Closing Date,
between Protalix Ltd. and the Israeli Security Trustee (the “Floating Charge”), the Security Agreement/Debenture,
dated as of the Closing Date, between the Company and the Israeli Security Trustee (the “Israeli Stock Pledge”)
and together with the U.S. Security Agreement, the IP Charge and the Floating Charge, the “Security Agreements”)
and the Engagement Letter, dated as of November 3, 2016, between Jefferies LLC (the “Placement Agent”) and
the Company (such engagement letter, the “Engagement Letter” and, together with this Note Purchase Agreement,
the Indenture, the Security Agreements and the Notes (as defined below), the “Transaction Agreements”), the
Company has authorized the issuance and sale of up to $35 million aggregate principal amount of 7.50% Secured Convertible Notes
(the “Notes”), to be issued pursuant to the Indenture to be dated as of the Closing Date, among the Company,
The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”), and Wilmington Savings Fund Society,
FSB, as collateral agent thereunder (the “Indenture”). The Notes are convertible into cash, shares of common
stock, par value $0.001 per share (the “Common Stock”), of the Company, or a combination thereof, at the Company’s
election. At the Closing (as defined in Section 1 of ANNEX B hereto), the Company will, subject to the terms
of this Note Purchase Agreement (including the terms and conditions set forth in ANNEX B), issue and sell to such
Purchaser and such Purchaser will buy from the Company, upon the terms and conditions hereinafter set forth, the principal amount
of Notes shown on such Purchaser’s signature page hereof.

 

		3.	The Notes purchased by such Purchaser will be delivered
by electronic book entry through the facilities of The Depository Trust Company (“DTC”) to an account specified
by such Purchaser set forth below and will be released by the Trustee, at the written instruction of the Company, to such Purchaser
at the Closing.

 

***Signature Page
Follows***

 

     

     

    

 

IN WITNESS
WHEREOF, the parties have caused this Note Purchase Agreement to be executed by their duly authorized representatives as of
the day and year first above written.

 

	 	PROTALIX BIOTHERAPEUTICS, INC.
	 	 
	 	By:	 
	 	Name:	 
	 	Title	 

 

[Signature Page to Note Purchase Agreement]

 

     

     

    

 

Print or Type:

 

	 	 
	 	Name of Purchaser
	 	(Individual or Institution)
	 	 
	 	Jurisdiction of Purchaser’s Executive Offices
	 	 
	 	Name of Individual representing Purchaser (if an Institution)
	 	 
	 	Title of Individual representing Purchaser (if an Institution)
	 	 
	 	$ 
	 	Principal amount of Notes to Be Purchased
	 	 
	 	Number of shares of Common Stock beneficially owned by Purchaser on the date hereof 1 

 

	Signature by:	Individual Purchaser or Individual representing Purchaser:
	 	 
	 	 
	 	Address: 	 
	 	Telephone:	 
	 	Facsimile:	 
	 	Email:	 

 

*** Please note that if you are sub-allocating
to multiple funds,

you must execute a signature page for each
fund. ***

 

 

 

		 1 	Include all shares of Common Stock, and all securities convertible into Common Stock on an as-converted
basis, held by the Purchaser and all of its affiliates.

 

[Signature Page to Note Purchase Agreement]

 

     

     

    

 

SUMMARY INSTRUCTION SHEET FOR PURCHASER

 

(To be read in conjunction with the entire
Note Purchase Agreement.)

 

Each Purchaser must complete the following
items in the Note Purchase Agreement:

 

		1.	Provide the information regarding such Purchaser requested
on the signature page and Purchaser Questionnaire attached as Annex A to the Note Purchase Agreement (the “Purchaser
Questionnaire”). The Note Purchase Agreement must be executed by an individual authorized to bind such Purchaser.

 

		2.	On or prior to 5:00 p.m., New York City time, on December
1, 2016, return an executed original Note Purchase Agreement or a facsimile transmission (or other electronic transmission) thereof
and the completed and executed Purchaser Questionnaire to:

 

Tim O’Connor

tim.oconnor@jefferies.com

Jefferies LLC

520 Madison Avenue, 2nd Floor

New York, New York 10022

 

		3.	On or prior to 5:00 p.m., New York City time, on the business
day immediately preceding the Closing Date (as defined in the Note Purchase Agreement), such Purchaser shall transfer the amount
indicated below such Purchaser’s name on the applicable signature page to the Note Purchase Agreement above the title “Principal
Amount of Notes to be Purchased,” in United States dollars and in immediately available funds, by wire transfer to the account
of Jefferies, as the Company’s closing agent (in such capacity, the “Closing Agent”). No payments will
be accepted on a delivery-versus-payment, or “DVP,” basis.

 

		4.	On or prior to 10:00 a.m., New York City time, on the Closing
Date, such Purchaser must instruct its custodian(s) to post a DWAC request for free receipt to The Bank of New York Mellon for
such Purchaser’s aggregate principal amount 1 
of Notes (CUSIP/ISIN # 74365AAC5 / US74365AAC53). It is important that this request be submitted on the Closing Date.
If the request is submitted before the Closing Date, it will expire and need to be resubmitted on the Closing Date.

 

		5.	Following the confirmation by the Closing Agent that the
conditions set forth in the Note Purchase Agreement, other than with respect to the issuance of and delivery of the Notes, have
been satisfied or waived, (i) the Closing Agent shall disburse on the Closing Date funds received by the Closing Agent on behalf
of the Company (net of the agreed amount of fees and expenses of the Placement Agent) by wire transfer of immediately available
funds to an account specified by the Company in accordance with the Company’s written wire instructions (which shall be
provided to the Closing Agent by the Company at least one business day prior to the Closing Date) and (ii) the principal amount
of Notes to be purchased by such Purchaser (as specified on such Purchaser’s signature page hereof) to be issued and delivered
by electronic book entry through the facilities of DTC to the account specified by such Purchaser in its Purchaser Questionnaire
will be released by the Trustee, at the written instruction of the Company, to such Purchaser upon receipt of Purchaser’s
DWAC deposit request.

 

 

 

	 1 	Note that the DWAC instruction should specify the principal amount, and not the number,
of Notes.

 

    	 	S-1	 

     

    

 

		6.	Please note that all wire transfers must be sent to
the following account, and the name of the purchasing entity must be included in the wire:

 

	Wire Information
	ABA Routing Number:	021000018
	Bank Name:	Bank of New York
	Account Name:	Jefferies LLC
	Account Number:	8900652772
	Re:	[Purchaser’s Account or Sub-Account Name]

 

The Closing Agent will notify
each Purchaser once the transaction has closed. Each Purchaser must instruct its custodian(s) to post a DWAC deposit in order to
receive Notes on the Closing Date.

 

		7.	If you have any questions, please contact Tim O’Connor
of Jefferies at 212-284-8137.

 

    	 	S-2	 

     

    

 

ANNEX A

 

PROTALIX BIOTHERAPEUTICS, INC.

 

PURCHASER QUESTIONNAIRE

 

Pursuant to Section 1.4 of ANNEX B
of the Note Purchase Agreement, please provide us with the following information:

 

	Legal Name of Purchaser (i.e., Fund Name):	 
	Address of Purchaser:	 
	 	 
	Attention:	 
	 	 
	Telephone Number:	 
	Fax Number:	 

 

NOMINEE/CUSTODIAN (Name in which
the Notes and, if applicable, Common Stock issued upon conversion of the Notes are to be registered if different than name of Purchaser):

 

	 	 
	 	 
	DTC Number:	 
	 	 
	Tax I.D. Number or Social Security Number:	 
	(If acquired in the name of a nominee/custodian, the taxpayer I.D. number of such nominee/custodian)

 

Person to Receive Copies of Transaction
Documents:

	Name:	 
	Telephone Number:	 
	Email:	 

Operations Contacts:

	Primary:	 
	Telephone Number:	 
	Email:	 
	 	 
	Secondary:	 
	Telephone Number:	 
	Email:	 

 

Each Purchaser must be a “qualified
institutional buyer” as defined in Rule 144A under the Securities Act.

 

*** Please note that if you are sub-allocating
to multiple funds, you must complete one of these forms for each fund.

 

    	 	Annex A-1	 

     

    

 

ANNEX B

 

NOTE PURCHASE AGREEMENT

 

TERMS AND CONDITIONS

 

Capitalized terms used
in this Annex B to the Note Purchase Agreement without definition have the respective meanings ascribed to them in the Note Purchase
Agreement.

 

The Company agrees,
and each Purchaser, severally and not jointly, agrees, as follows:

 

1.          Delivery
of the Notes at the Closing; Termination.

 

1.1           Closing.
The closing of the purchase and sale of the Notes (the “Closing”) shall occur at the offices of Latham &
Watkins LLP, 885 Third Avenue, New York, NY 10022, on the third business day following the execution of the Note Purchase Agreement
or on such later date or at such different location as the parties shall agree in writing but not prior to the date that the conditions
for Closing set forth below have been satisfied or waived by the appropriate party (the date of such Closing being referred to
herein as the “Closing Date”).

 

1.2           Closing
Deliveries. Subject to Section 1.3 below, (a) on or prior to the Closing Date, such Purchaser shall pay, in immediately
available funds, the full amount of the purchase price for the Notes being purchased hereunder by wire transfer to the account
specified by Jefferies, as closing agent (in such capacity, the “Closing Agent”) and (b) on the Closing Date,
such Purchaser shall instruct its custodian(s) to post a DWAC request for free receipt to The Bank of New York Mellon for such
Purchaser’s aggregate principal amount of Notes (CUSIP/ISIN # 74365AAC5 / US74365AAC53), which shall be made through the
facilities of DTC. The name(s) in which the book-entry Notes are to be registered are set forth in such Purchaser’s Purchaser
Questionnaire attached as ANNEX A to the Note Purchase Agreement.

 

1.3           Closing
Mechanics.

 

(a)          On
or prior to 5:00 p.m., New York City time, on the business day immediately preceding the Closing Date, such Purchaser will pay
the full amount of the purchase price for the Notes being purchased hereunder to the Closing Agent as required by Section 1.2
above. In the event that such Purchaser shall fail to deliver all or any portion of the purchase price for the Notes being purchased
on or before 5:00 p.m., New York City time, on the business day immediately preceding the Closing Date, the Closing Agent will
be permitted (but will not be obligated), in its sole discretion, to fund the purchase price for the Notes being purchased on behalf
of such Purchaser; provided, however, that the funding of the purchase of any Notes by the Closing Agent pursuant
to this Section 1.3(a) will not relieve such Purchaser of any liability that it may have to the Company or the Closing Agent
pursuant to the Note Purchase Agreement or for the breach of its obligations under the Note Purchase Agreement. In any such case
in which the Closing Agent, in its sole discretion, has elected to fund the purchase price for the Notes being purchased on behalf
of such Purchaser, the Closing Agent may direct the delivery and release of the Notes to the Closing Agent’s account pending
payment by such Purchaser, and if such Purchaser has not fulfilled its obligation to purchase the Notes as set forth herein within
two business days of the Closing Date, the Closing Agent will thereafter be entitled to direct disposition of the Notes in such
manner as it deems appropriate (including the purchase thereof for its own account).

 

    	 	Annex B-1	 

     

    

 

(b)          In
the event that the Closing Agent shall have funded the purchase of the Notes on behalf of such Purchaser under the circumstances
set forth in clause 1.3(a) above, such Purchaser shall be obligated to repay the Closing Agent in exchange for the release
of the Notes to such Purchaser at a purchase price for the Notes equal to 100% of the purchase price for the Notes being purchased
by such Purchaser plus accrued interest from the Closing Date; provided, however, that if the Closing Agent has funded
such purchase on behalf of such Purchaser, and such Purchaser subsequently makes payment to the Closing Agent before 9:00 a.m.,
New York City time, on the Closing Date, the purchase price shall equal the purchase price for such Notes plus an amount equal
to the Closing Agent’s cost of intraday funds for such purchase.

 

(c)          The
receipt of funds by the Closing Agent from such Purchaser shall be deemed to be irrevocable instructions from such Purchaser to
the Closing Agent that the conditions to the Closing have been satisfied.

 

(d)          Funds
received by the Closing Agent on behalf of the Company pursuant to this Section 1 (or funded by the Closing Agent in its
sole discretion pursuant to Section 1.3(a) above) will be held in trust and not as property or in the title of the Closing
Agent. On the Closing Date, or as soon as reasonably practicable thereafter, the Closing Agent will disburse such funds (net of
the agreed amount of fees and expenses of the Placement Agent set forth in the Engagement Letter) by wire transfer of immediately
available funds in accordance with the Company’s written wire instructions (which shall be provided to the Closing Agent
at least one business day prior to the Closing Date), unless otherwise agreed to by the Company and the Closing Agent.

 

(e)          Immediately
following the Company’s receipt of such funds, the Notes purchased by such Purchaser (as specified on the signature page
hereof) will be issued by the Company and delivered pursuant to Section 1.2 above.

 

1.4           Conditions
to the Company’s Obligations. The Company’s obligation to complete the purchase and sale of the Notes and deliver
such Notes by book entry to such Purchaser at the Closing shall be subject to the following conditions, any one or more of which
may be waived by the Company:

 

(a)          receipt
by the Company of same-day funds in the full principal amount of the Notes being purchased hereunder;

 

(b)          completion
of the purchases of the Notes under the Note Purchase Agreement by the other Purchasers;

 

(c)          completion
of the exchange and other transactions contemplated under the exchange agreement, dated December 1, 2016, by and among the Company
and the parties identified therein (the “Exchange Agreement”);

 

    	 	Annex B-2	 

     

    

 

(d)          the
accuracy of the representations and warranties made by such Purchaser and the other Purchasers in the Note Purchase Agreement;
and

 

(e)          receipt
by the Company from such Purchaser of the fully completed Purchaser Questionnaire (which is set forth in ANNEX A to
the Note Purchase Agreement).

 

1.5           Conditions
to the Purchasers’ Obligations. Such Purchaser’s obligation to pay for the Notes to be purchased by it shall be
subject to the following conditions, any one or more of which may be waived by such Purchaser:

 

(a)          receipt
by the Closing Agent on behalf of such Purchaser of the Note Purchase Agreement, executed and delivered by a responsible officer
of the Company;

 

(b)          receipt
by the Closing Agent on behalf of such Purchaser of fully executed copies of the Indenture and the Notes;

 

(c)          receipt
by the Closing Agent on behalf of such Purchaser of the Security Agreements, executed and delivered by a responsible officer of
the Company and each other party thereto;

 

(d)          the
delivery to the Closing Agent on behalf of such Purchaser by U.S. counsel to the Company of a legal opinion substantially similar
in substance to the form of opinion attached as ANNEX C-1 to the Note Purchase Agreement;

 

(e)          the
delivery to the Closing Agent on behalf of such Purchaser by Israeli counsel to the Company of a legal opinion substantially similar
in substance to the form of opinion attached as ANNEX C-2 to the Note Purchase Agreement;

 

(f)          receipt
by the Closing Agent on behalf of such Purchaser of a certificate executed by the chief executive officer and the chief financial
officer of the Company, dated as of the Closing Date, in substantially the form of certificate attached as ANNEX D
to the Note Purchase Agreement;

 

(g)          receipt
by the Closing Agent on behalf of such Purchaser of a certificate of the Secretary of the Company, dated as of the Closing Date,
in substantially the form of certificate attached as ANNEX E to the Note Purchase Agreement:

 

(i)          certifying
the resolutions adopted by the Board of Directors of the Company approving the transactions contemplated by the Transaction Agreements
and the sale of the Notes and the reservation and issuance of the shares of Common Stock potentially issuable upon the conversion
of the Notes;

 

(ii)         certifying
the current versions of the Certificate of Incorporation and the Bylaws of the Company; and

 

    	 	Annex B-3	 

     

    

 

(iii)        certifying
as to the signatures and authority of the persons signing the Note Purchase Agreement and related documents on behalf of the Company;

 

(h)          receipt
by the Closing Agent on behalf of the Purchaser of a certificate of good standing for the Company for its jurisdiction of incorporation;

 

(i)          on
or prior to the Closing Date, the Company shall have received the approval of the Israeli National Authority for Technological
Innovation (formerly known as the Office of the Chief Scientist of the Israeli Ministry of the Economy) (the “Israeli
Innovation Authority”) in connection with the grant of a security interest in certain of the Security Assets (as defined
in the IP Charge and the Floating Charge) and the Trustee shall have executed and delivered the undertakings on behalf of each
Purchaser towards the Israeli Innovation Authority, in the form requested by the Israeli Innovation Authority;

 

(j)          the
Common Stock shall continue to be listed on the New York Stock Exchange Market (“NYSE MKT”) as of the Closing
Date; there shall have been no suspensions in the trading of the Common Stock as of the Closing Date; and the listing of additional
shares notification form with respect to the maximum number of shares of Common Stock that may be issued upon conversion of the
Notes (including the maximum number of Additional Shares (as defined in the Indenture) that may be added to the Conversion Rate
(as defined in the Indenture)), assuming the Company elected to settle all conversions solely in shares of Common Stock, shall
have been submitted to NYSE MKT and NYSE MKT shall have confirmed that it has no objection to such notification;

 

(k)          no
injunction, restraining order, action or order of any nature by a governmental or regulatory authority shall have been issued,
taken or made or no action shall have been taken and no statute, rule, regulation or order shall have been enacted, adopted or
issued by any federal, state or foreign governmental or regulatory authority of competent jurisdiction that would, prior to or
as of the Closing Date, prevent or materially interfere with the consummation of the transactions contemplated by the Note Purchase
Agreement; and

 

(l)          prior
to the Closing, there shall not have occurred a material adverse effect or any development involving a prospective material adverse
effect in the general affairs, business, properties, management, financial condition or results of operations of the Company from
that set forth in the Disclosure Package and the Final Memorandum.

 

2.             Representations,
Warranties and Covenants of the Company. The Company hereby represents and warrants to, and covenants with, such Purchaser,
the Placement Agent and the Closing Agent as follows:

 

2.1           The
Preliminary Private Placement Memorandum, dated November 10, 2016, as amended by the Amended and Restated Preliminary Private Placement
Memorandum, dated November 29, 2016, including any and all exhibits thereto and any information incorporated by reference therein
(the “Preliminary Memorandum”), as of the date thereof, did not contain any untrue statement of a material fact
or omit to state any material fact necessary to make the statements therein, in the light of the circumstances under which they
were made, not misleading. As of its date and the Closing Date, the final private placement memorandum (as then amended or supplemented
including any and all exhibits thereto and any information incorporated by reference therein, the “Final Memorandum”),
did not and will not (and any amendment or supplement thereto, at the date thereof and at the Closing Date, will not) contain any
untrue statement of a material fact or omit to state any material fact necessary to make the statements therein, in the light of
the circumstances under which they were made, not misleading; provided, however, that the Company makes no representation
or warranty as to the information concerning the Placement Agent contained in or omitted from the Preliminary Memorandum or the
Final Memorandum, or any amendment or supplement thereto, in reliance upon and in conformity with information furnished in writing
to the Company by or on behalf of the Placement Agent specifically for inclusion therein.

 

    	 	Annex B-4	 

     

    

 

2.2           The
Preliminary Memorandum and the final term sheet related to the Notes distributed in connection with pricing the offering of the
Notes (together with the Preliminary Memorandum, the “Disclosure Package”), at 4:00 P.M., New York City time,
as of the date hereof (the “Execution Time”), does not contain any untrue statement of a material fact or omit
to state any material fact necessary in order to make the statements therein, in the light of the circumstances under which they
were made, not misleading. The preceding sentence does not apply to statements in or omissions from the Disclosure Package based
upon and in conformity with written information concerning the Placement Agent furnished to the Company by the Placement Agent
specifically for use therein.

 

2.3           None
of the Company, its affiliates (within the meaning of Rule 144 under the Securities Act) or any person acting on its or their behalf
has directly or indirectly made offers or sales of any security, or solicited offers to buy any security, under circumstances that
would require the registration of the offer and sale of the Notes or the Common Stock potentially issuable upon conversion thereof
under the Securities Act.

 

2.4           None
of the Company, its Affiliates or any person acting on its or their behalf has: (a) engaged in any form of general solicitation
or general advertising in connection with any offer or sale of the Notes or (b) engaged in any directed selling efforts (within
the meaning of Regulation S under the Securities Act) with respect to the Notes or the Common Stock potentially issuable upon conversion
thereof.

 

2.5           The
Notes satisfy the eligibility requirements of Rule 144A(d)(3) under the Securities Act.

 

2.6           No
registration under the Securities Act of the offer and sale of the Notes or the Common Stock potentially issuable upon conversion
thereof is required for, and no qualification of the Indenture under the Trust Indenture Act of 1939, as amended, and the rules
and regulations of the United States Securities and Exchange Commission (the “Commission”) promulgated thereunder
is required in connection with, the offer and sale of the Notes to the Purchasers in the manner contemplated herein, the Disclosure
Package and the Final Memorandum.

 

2.7           The
Company is not, and after giving effect to the offering and sale of the Notes and the application of the proceeds thereof as described
in the Disclosure Package and the Final Memorandum will not be, an “investment company” as defined in the U.S. Investment
Company Act of 1940, as amended, and the rules and regulations of the Commission promulgated thereunder.

 

    	 	Annex B-5	 

     

    

 

2.8           The
Company is subject to and in full compliance with the reporting requirements of Section 13 or Section 15(d) of the Securities Exchange
Act of 1934, as amended, (the “Exchange Act”).

 

2.9           The
Company has not paid or agreed to pay to any person any compensation for soliciting another to purchase any securities of the Company
(except as contemplated in the Note Purchase Agreement and the Engagement Letter).

 

2.10         The
Company has not taken, directly or indirectly, any action designed to or that has constituted or that might reasonably be expected
to cause or result, under the Exchange Act or otherwise, in stabilization or manipulation of the price of any security of the Company
to facilitate the sale or resale of the Notes or the shares of Common Stock potentially issuable upon conversion of the Notes.

 

2.11         The
Company has been duly incorporated and is validly existing as a corporation in good standing under the laws of the State of Delaware,
with full corporate power and authority to own or lease, as the case may be, and to operate its properties and conduct its business
as described in the Disclosure Package and the Final Memorandum, and is duly qualified to do business as a foreign corporation
and is in good standing under the laws of each jurisdiction that requires such qualification, except where the failure to be so
qualified would not, individually or in the aggregate, have a material adverse effect on the condition (financial or otherwise),
prospects, earnings, business or properties of the Company and its subsidiaries, taken as a whole, whether or not arising from
transactions in the ordinary course of business (a “Material Adverse Effect”).

 

2.12         Each
subsidiary of the Company has been duly incorporated and is validly existing under the laws of its state of incorporation or formation,
is duly qualified to do business in each jurisdiction in which its ownership or lease of property or the conduct of its businesses
requires such qualification and has all power and authority necessary to own or hold its properties and to conduct the businesses
in which it is engaged, except where the failure to be so qualified, individually or in the aggregate, would not reasonably be
expected to have a Material Adverse Effect.

 

2.13         All
the outstanding shares of capital stock of each subsidiary have been duly authorized and validly issued and are fully paid and
nonassessable, and, except as otherwise set forth in the Disclosure Package and the Final Memorandum, all outstanding shares of
capital stock of the subsidiaries are owned by the Company either directly or through wholly owned subsidiaries free and clear
of any security interest, claim, lien or encumbrance.

 

    	 	Annex B-6	 

     

    

 

2.14         The
authorized, issued and outstanding capital stock of the Company is as set forth in each of the Disclosure Package and the Final
Memorandum (other than for subsequent issuances, if any, pursuant to employee benefit plans described in each of the Disclosure
Package and the Final Memorandum or upon the exercise of outstanding options or warrants described in each of the Disclosure Package
and the Final Memorandum); the Common Stock conforms in all material respects to the description thereof contained in each of the
Disclosure Package and the Final Memorandum; all of the issued and outstanding shares of Common Stock have been duly authorized
and validly issued, are fully paid and nonassessable and have been issued in compliance with federal and state securities laws;
none of the outstanding shares of Common Stock was issued in violation of any preemptive rights, rights of first refusal or other
similar rights to subscribe for or purchase securities of the Company; there are no authorized or outstanding options, warrants,
preemptive rights, rights of first refusal or other rights to purchase, or equity or debt securities convertible into or exchangeable
or exercisable for, any capital stock of the Company or any of its subsidiaries other than those accurately described in each of
the Disclosure Package and the Final Memorandum; the description of the Company’s stock option, stock bonus and other stock
plans or arrangements, and the options or other rights granted thereunder, set forth in each of the Disclosure Package and the
Final Memorandum accurately and fairly presents the information required to be shown with respect to such plans, arrangements,
options and rights; all grants of options to acquire shares of Common Stock (each, a “Company Stock Option”)
were validly issued and approved by the Board of Directors of the Company, a committee thereof or an individual with authority
duly delegated by the Board of Directors of the Company or a committee thereof; grants of Company Stock Options were (a) made in
material compliance with all applicable laws and (b) as a whole, made in material compliance with the terms of the plans under
which such Company Stock Options were issued; there is no and has been no policy or practice of the Company to coordinate the grant
of Company Stock Options with the release or other public announcement of material information regarding the Company or its results
of operations or prospects; the maximum number of shares of Common Stock initially issuable upon conversion of the Notes (including
the maximum number of Additional Shares (as defined in the Indenture) that may be added to the Conversion Rate (as defined in the
Indenture), assuming Capped Combination Settlement (as defined in the Indenture) and assuming that the NYSE MKT Shareholder Approval
(as defined in the Indenture) has been obtained, with the number of shares of Common Stock included in each Daily Settlement Amount
(as defined in the Indenture) equal to the Daily Share Cap (as defined in the Indenture)), have been duly authorized and, when
issued upon conversion of the Notes in accordance with the Indenture, will be validly issued, fully paid and nonassessable; the
Board of Directors of the Company has duly and validly adopted resolutions reserving such shares of Common Stock for issuance upon
conversion of the Notes; the holders of outstanding shares of capital stock of the Company are not entitled to preemptive or other
rights to subscribe for the Notes or the shares of Common Stock potentially issuable upon conversion thereof; and, except as described
in each of the Disclosure Package and the Final Memorandum, the Company has not sold or issued any shares of Common Stock during
the six-month period preceding the date of the Final Memorandum, including any sales pursuant to Rule 144A under, or Regulations
D or S of, the Securities Act other than shares issued pursuant to employee benefit plans, qualified stock options plans or other
employee compensation plans or pursuant to outstanding options, rights or warrants.

 

2.15         Protalix
Ltd. is authorized to pledge to Altshuler Shaham Trust Ltd., as security trustee, for the benefit of the Trustee (on behalf of
the Purchasers), a security interest in all (or a portion) of its assets, subject to the approval of the Israeli National Authority
for Technological Innovation and in accordance with the provisions of the Israeli Encouragement of Research, Development and Technological
Innovation in Industry Law, 5744-1984 (the “Research Law”).

 

    	 	Annex B-7	 

     

    

 

2.16         Other
than as stipulated in Section 2.15 and as may be required under the blue sky laws of any jurisdiction in which the Notes
are offered and sold, no consent, approval, authorization, filing with or order of any court or governmental agency or body is
required in connection with the transactions contemplated by the Transaction Agreements. No shareholder approval is required under
the rules of The NYSE MKT in connection with the initial sale of the Notes.

 

2.17         The
statements in or incorporated by reference in the Preliminary Memorandum and the Final Memorandum under the headings “U.S.
Federal Income Tax Consequences,” “Business—Intellectual Property,” “Business—International
Regulation,” “Business—Israeli Government Programs,” “Risk Factors—Risks Related to Intellectual
Property Matters—If we fail to adequately protect or enforce our intellectual property rights or secure rights to third-party
patents, the value of our intellectual property rights would diminish and our business, competitive position and results of operations
would suffer,” “Risk Factors—Risks Related to Intellectual Property Matters—If we cannot meet requirements
under our license agreements, we could lose the rights to our products, which could have a material adverse effect on our business”
and “Risk Factors—Risks Relating to Our Operations in Israel,” insofar as such statements summarize legal matters,
agreements, documents or proceedings discussed therein, are accurate and fair summaries in all material respects of such legal
matters, agreements, documents or proceedings.

 

2.18         The
Note Purchase Agreement has been duly authorized, executed and delivered by the Company; the Security Agreements have been duly
authorized, executed and delivered by the Company or Protalix Ltd., as applicable; the Indenture has been duly authorized and,
assuming due authorization, execution and delivery thereof by the Trustee and the Collateral Agent, when executed and delivered
by the Company and the guarantors party thereto, will constitute a legal, valid, binding instrument enforceable against the Company
in accordance with its terms (subject, as to the enforcement of remedies, to applicable bankruptcy, reorganization, insolvency,
moratorium or other laws affecting creditors’ rights generally from time to time in effect and to general principles of equity);
and the Notes have been duly authorized and, when executed and authenticated in accordance with the provisions of the Indenture
and delivered to and paid for by the Purchasers, will have been duly executed and delivered by the Company and will constitute
the legal, valid and binding obligations of the Company entitled to the benefits of the Indenture (subject, as to the enforcement
of remedies, to applicable bankruptcy, reorganization, insolvency, moratorium or other laws affecting creditors’ rights generally
from time to time in effect and to general principles of equity) and will be convertible into Common Stock in accordance with their
terms.

 

2.19         None
of the execution and delivery of the Transaction Agreements, the issuance and sale of the Notes or the issuance of the Common Stock
upon conversion thereof, the consummation of any other of the transactions herein or therein contemplated, or the fulfillment of
the terms hereof or thereof, will conflict with, result in a breach or violation or imposition of any lien, charge or encumbrance
upon any property or assets of the Company or any of its subsidiaries pursuant to, (a) the charter or by-laws or comparable constituting
documents of the Company or any of its subsidiaries; (b) the terms of any indenture, contract, lease, mortgage, deed of trust,
note agreement, loan agreement or other agreement, obligation, condition, covenant or instrument to which the Company or any of
its subsidiaries is a party or bound or to which its or their property is subject; or (c) any statute, law, rule, regulation, judgment,
order or decree of any court, regulatory body, administrative agency, governmental body, arbitrator or other authority having jurisdiction
over the Company or any of its subsidiaries or any of its or their properties, except, in the cases of clauses (b) and (c), as
would not, singly or in the aggregate, have a Material Adverse Effect.

 

    	 	Annex B-8	 

     

    

 

2.20         The
consolidated historical financial statements and schedules of the Company and its consolidated subsidiaries included or incorporated
by reference in the Disclosure Package and the Final Memorandum present fairly the financial condition, results of operations
and cash flows of the Company as of the dates and for the periods indicated and comply as to form with the applicable accounting
requirements of Regulation S-X under the Securities Act; and have been prepared in conformity with generally accepted accounting
principles in the United States applied on a consistent basis throughout the periods involved (except as otherwise noted therein).

 

2.21         No
action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company
or any of its subsidiaries or its or their property is pending or, to the knowledge of the Company, threatened that (a) could,
individually or in the aggregate, reasonably be expected to have a material adverse effect on the performance of the Transaction
Agreements or the consummation of any of the transactions contemplated hereby or thereby or (b) could, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect, except as set forth in or contemplated in the Disclosure Package and
the Final Memorandum.

 

2.22         Each
of the Company and its subsidiaries owns or leases all such properties as are reasonably necessary to the conduct of its operations
as presently conducted.

 

2.23         Neither
the Company nor any of its subsidiaries is in violation or default of (a) any provision of its charter or bylaws or comparable
constituting documents; (b) the terms of any indenture, contract, lease, mortgage, deed of trust, note agreement, loan agreement
or other agreement, obligation, condition, covenant or instrument to which it is a party or bound or to which its property is subject;
or (c) any statute, law, rule, regulation, judgment, order or decree applicable to the Company or any of its subsidiaries of any
court, regulatory body, administrative agency, governmental body, arbitrator or other authority having jurisdiction over the Company
or such subsidiary or any of its properties, as applicable, except, in the cases of clauses (b) and (c), as would not, singly or
in the aggregate, have a Material Adverse Effect.

 

2.24         Kesselman
& Kesselman, a member of PricewaterhouseCoopers International Limited, which has certified certain financial statements of
the Company and its consolidated subsidiaries and delivered its report with respect to the audited consolidated financial statements
and schedules included or incorporated by reference in the Disclosure Package and the Final Memorandum, is an independent registered
public accounting firm with respect to the Company within the meaning of the Securities Act and the applicable published rules
and regulations thereunder and under the rules of the Public Company Accounting Oversight Board.

 

    	 	Annex B-9	 

     

    

 

2.25         There
are no stamp or other issuance or transfer taxes or duties or other similar fees or charges required to be paid in connection with
the execution and delivery of the Note Purchase Agreement or the issuance, sale or resale of the Notes or upon the issuance of
Common Stock upon the conversion thereof.

 

2.26         The
Company has filed all applicable tax returns that are required to be filed or has requested extensions thereof (except in any case
in which the failure to so file would not have a Material Adverse Effect and except as set forth or contemplated in the Disclosure
Package and the Final Memorandum) and has paid all taxes required to be paid by it and any other assessment, fine or penalty levied
against it, to the extent that any of the foregoing is due and payable, except for any such assessment, fine or penalty that is
currently being contested in good faith or as would not have a Material Adverse Effect and except as set forth in or contemplated
in the Disclosure Package and the Final Memorandum.

 

2.27         No
labor problem or dispute with the employees of the Company or any of its subsidiaries exists or is threatened or imminent, and
the Company is not aware of any existing or imminent labor disturbance by the employees of any of its or its subsidiaries’
principal suppliers, contractors or customers, except as would not have a Material Adverse Effect and except as set forth in or
contemplated in the Disclosure Package and the Final Memorandum.

 

2.28         The
Company and each of its subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks
and in such amounts as are prudent and customary in the businesses in which they are engaged; all policies of insurance and fidelity
or surety bonds insuring the Company or any of its subsidiaries or their respective businesses, assets, employees, officers and
directors are in full force and effect; the Company and its subsidiaries are in compliance with the terms of such policies and
instruments; there are no claims by the Company or any of its subsidiaries under any such policy or instrument as to which insurance
company is denying liability or defending under a reservation of rights clause; neither the Company nor any of its subsidiaries
has been refused any insurance coverage sought or applied for; and neither the Company nor any of its subsidiaries has any reason
to believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar
coverage from similar insurers as may be necessary to continue its business at a cost that would not have a Material Adverse Effect
except as set forth or contemplated in the Disclosure Package and the Final Memorandum.

 

2.29         No
subsidiary of the Company is currently prohibited, directly or indirectly, from paying any dividends to the Company, from making
any other distribution on such subsidiary’s capital stock, from repaying to the Company any loans or advances to such subsidiary
from the Company or from transferring any of such subsidiary’s property or assets to the Company or any other subsidiary
of the Company, except as described in or contemplated in the Disclosure Package and the Final Memorandum.

 

2.30         The
Company and its subsidiaries possess and are in compliance in all material respects with the terms of all licenses, approvals,
orders, certificates, permits and other authorizations (collectively, “Licenses”) issued by all applicable authorities,
including, without limitation, all such Licenses required by the U.S. Food and Drug Administration or any component thereof and/or
by any other U.S. state, local or foreign government or drug regulatory agency (collectively, the “Regulatory Agencies”)
necessary to conduct their respective businesses as described in the Disclosure Package and the Final Memorandum, and neither the
Company nor any such subsidiary has received any notice of proceedings relating to the revocation or modification of, or non-compliance
with, any such License that, singly or in the aggregate, if the subject of an unfavorable decision, ruling or finding, would have
a Material Adverse Effect, except as set forth or contemplated in the Disclosure Package and the Final Memorandum, and all such
Licenses are in full force and effect.

 

    	 	Annex B-10	 

     

    

 

2.31         The
preclinical tests and clinical trials that are described in, or the results of which are referred to in, the Disclosure Package
and the Final Memorandum were and, if still pending, are being conducted in all material respects in accordance with protocols
filed with the appropriate Regulatory Agencies for each such test or trial, as the case may be, and with standard medical and scientific
research procedures and all applicable statutes, directives, rules and regulations of the Regulatory Agencies, including, without
limitation, the Federal Food, Drug and Cosmetic Act and the rules and regulations promulgated thereunder; each description of such
tests and trials, and the results thereof, contained in the Disclosure Package and the Final Memorandum is accurate and complete
in all material respects and fairly presents the data about and derived from such tests and trials, and the Company has no knowledge
of any other studies or tests, the results of which are inconsistent with, or otherwise call into question, the results described
or referred to in the Disclosure Package and the Final Memorandum; neither the Company nor its subsidiaries has received any notices
or other correspondence from any Regulatory Agency requiring the termination, suspension or modification of any clinical trials
that are described or referred to in the Disclosure Package and the Final Memorandum; and each of the Company and its subsidiaries
has operated and currently is in compliance in all material respects with all applicable rules and regulations of the Regulatory
Agencies.

 

2.32         The
Company and each of its subsidiaries: (a) are and have been in material compliance with applicable health care laws, including,
without limitation, the Federal Food, Drug and Cosmetic Act (21 U.S.C. § 301 et seq.), the Federal Anti-kickback Statute (42 U.S.C.
§ 1320a-7b(b)), Physician Payment Sunshine Act (42 U.S.C. § 1320a-7h), the civil False Claims Act (31 U.S.C. §§
3729 et seq.), the administrative False Claims Law (42 U.S.C. § 1320a-7b(a)), the Anti-Inducement Law (42 U.S.C.
§ 1320a-7a(a)(5)), the Health Insurance Portability and Accountability Act of 1996 (42 U.S.C. § 1320d et seq.), as amended
by the Health Information Technology for Economic and Clinical Health Act of 2009, the exclusion laws, Social Security Act §
1128 (42 U.S.C. § 1320a-7), Medicare (Title XVIII of the Social Security Act), Medicaid (Title XIX of the Social Security
Act) and the regulations promulgated pursuant to such laws, and comparable state laws, and all other local, state, federal, national,
supranational and foreign laws, manual provisions, policies and administrative guidance relating to the regulation of the Company
and its subsidiaries (collectively, “Health Care Laws”); (b) have not received notice of any ongoing claim,
action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any Regulatory Agency or third
party alleging that any product operation or activity is in material violation of any Health Care Laws and has no knowledge that
any such Regulatory Agency or third party is considering any such claim, litigation, arbitration, action, suit, investigation or
proceeding; and (c) are not a party to any corporate integrity agreement, deferred prosecution agreement, monitoring agreement,
consent decree, settlement order or similar agreements or have any reporting obligations pursuant to any such agreement, plan or
correction or other remedial measure entered into with any governmental authority. Neither the Company nor its subsidiaries or
any of their officers, directors, employees, agents or contractors has been or is currently debarred, suspended or excluded from
participation in the Medicare and Medicaid programs or any other state or federal health care program.

 

    	 	Annex B-11	 

     

    

 

2.33         The
Company and each of its subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurance
that (a) transactions are executed in accordance with management’s general or specific authorizations; (b) transactions are
recorded as necessary to permit preparation of financial statements in conformity with generally accepted accounting principles
in the United States and to maintain asset accountability; (c) access to assets is permitted only in accordance with
management’s general or specific authorization; and (d) the recorded accountability for assets is compared with the existing
assets at reasonable intervals and appropriate action is taken with respect to any differences. The Company and its subsidiaries’
internal controls over financial reporting are effective, and the Company and its subsidiaries are not aware of any material weakness
in their internal control over financial reporting.

 

2.34         The
Company and its subsidiaries maintain “disclosure controls and procedures” (as such term is defined in Rules 13a-15(e)
under the Exchange Act); such disclosure controls and procedures are effective to provide reasonable assurance that information
required to be disclosed in the Company’s Exchange Act reports is recorded, processed, summarized and reported within the
time periods specified by the Commission and that material information related to the Company and its consolidated subsidiaries
is made known to management, including the Company’s Chief Executive Officer and Chief Financial Officer, particularly during
the period when the Company’s periodic reports are being prepared to allow timely decisions regarding required disclosure.

 

2.35         The
Company and its subsidiaries (a) are in compliance with any and all applicable foreign, federal, state and local laws and regulations
relating to the protection of human health and safety, the environment or hazardous or toxic substances or wastes, pollutants or
contaminants (“Environmental Laws”); (b) have received and are in compliance with all permits, licenses or other
approvals required of them under applicable Environmental Laws to conduct their respective businesses; and (c) have not received
notice of any actual or potential liability under any Environmental Law, except where such non-compliance with Environmental Laws,
failure to receive required permits, licenses or other approvals or liability would not, individually or in the aggregate, have
a Material Adverse Effect, except as set forth in or contemplated in the Disclosure Package and the Final Memorandum. Except as
set forth in the Disclosure Package and the Final Memorandum, neither the Company nor any of its subsidiaries has been named as
a “potentially responsible party” under the Comprehensive Environmental Response, Compensation and Liability Act of
1980, as amended.

 

2.36         In
the ordinary course of its business, the Company periodically reviews the effect of Environmental Laws on the business, operations
and properties of the Company and its subsidiaries, in the course of which it identifies and evaluates associated costs and liabilities
(including, without limitation, any capital or operating expenditures required for clean-up, closure of properties or compliance
with Environmental Laws or any permit, license or approval, any related constraints on operating activities and any potential liabilities
to third parties); on the basis of such review, the Company has reasonably concluded that such associated costs and liabilities
would not, singly or in the aggregate, have a Material Adverse Effect, except as set forth or contemplated in the Disclosure Package
and the Final Memorandum.

 

    	 	Annex B-12	 

     

    

 

2.37         None
of the following events has occurred or exists: (a) a failure to fulfill the obligations, if any, under the minimum funding standards
of Section 302 of the United States Employee Retirement Income Security Act of 1974, as amended (“ERISA”), and
the regulations and published interpretations thereunder with respect to a Plan (as defined below), determined without regard to
any waiver of such obligations or extension of any amortization period; (b) an audit or investigation by the Internal Revenue Service,
the U.S. Department of Labor, the Pension Benefit Guaranty Corporation or any other federal or state governmental agency or any
foreign regulatory agency with respect to the employment or compensation of employees by any of the Company or any of its subsidiaries
that could have a Material Adverse Effect, except as set forth or contemplated in the Disclosure Package and the Final Memorandum;
(c) any breach of any contractual obligation, or any violation of law or applicable qualification standards, with respect
to the employment or compensation of employees by the Company or any of its subsidiaries that could have a Material Adverse Effect,
except as set forth or contemplated in the Disclosure Package and the Final Memorandum. None of the following events has occurred
or is reasonably likely to occur: (i) a material increase in the aggregate amount of contributions required to be made to all Plans
in the current fiscal year of the Company and its subsidiaries compared to the amount of such contributions made in the most recently
completed fiscal year of the Company and its subsidiaries; (ii) a material increase in the “accumulated post-retirement benefit
obligations” (within the meaning of FASB ASC Topic 715) of the Company and its subsidiaries compared to the amount of such
obligations in the most recently completed fiscal year of the Company and its subsidiaries; (iii) any event or condition giving
rise to a liability under Title IV of ERISA that could have a Material Adverse Effect, except as set forth in or contemplated in
the Disclosure Package and the Final Memorandum; or (iv) the filing of a claim by one or more employees or former employees of
the Company or any of its subsidiaries related to their employment that could have a Material Adverse Effect, except as set forth
or contemplated in the Disclosure Package and the Final Memorandum. For purposes of this paragraph, the term “Plan”
means a plan (within the meaning of Section 3(3) of ERISA) subject to Title IV of ERISA with respect to which the Company
or any of its subsidiaries may have any liability.

 

2.38         The
subsidiaries listed on ANNEX F  to the Note Purchase Agreement are the only “significant subsidiaries”
of the Company (as defined in Rule 1-02 of Regulation S-X).

 

2.39         None
of the Company, its subsidiaries or, to the knowledge of the Company, any director, officer, agent, employee or Affiliate (as defined
below) of the Company or any of its subsidiaries is aware of or has taken any action, directly or indirectly, that would result
in a violation by such persons of the Foreign Corrupt Practices Act of 1977, as amended, and the rules and regulations thereunder
(the “FCPA”), including, without limitation, making use of the mails or any means or instrumentality of interstate
commerce corruptly in furtherance of an offer, payment, promise to pay or authorization of the payment of any money, or other property,
gift, promise to give, or authorization of the giving of anything of value to any “foreign official” (as such term
is defined in the FCPA) or any foreign political party or official thereof or any candidate for foreign political office, in contravention
of the FCPA; the Company, its subsidiaries and, to the knowledge of the Company, its Affiliates have conducted their businesses
in compliance with the FCPA and have instituted and maintained policies and procedures designed to ensure, and which are reasonably
expected to continue to ensure, continued compliance therewith. “Affiliate” has the meaning given to it in Rule
144(a) under the Securities Act.

 

    	 	Annex B-13	 

     

    

 

2.40         The
operations of the Company and its subsidiaries are and have been conducted at all times in compliance with applicable financial
recordkeeping and reporting requirements and money laundering statutes and the rules and regulations thereunder and any related
or similar rules, regulations or guidelines, issued, administered or enforced by any governmental agency (collectively, the “Money
Laundering Laws”), and no action, suit or proceeding by or before any court or governmental agency, authority or body
or any arbitrator involving the Company or any of its subsidiaries with respect to the Money Laundering Laws is pending or, to
the knowledge of the Company, threatened.

 

2.41         None
of the Company, any of its subsidiaries or, to the knowledge of the Company, any director, officer, agent, employee or Affiliate
of the Company or any of its subsidiaries is currently subject to any sanctions administered by the Office of Foreign Assets Control
of the U.S. Department of the Treasury (“OFAC”), and the Company will not, directly or indirectly, use the proceeds
of the offering of the Notes hereunder, or lend, contribute or otherwise make available such proceeds to any subsidiary, joint
venture partner or other person or entity, for the purpose of financing the activities of any person currently subject to any U.S. sanctions
administered by OFAC.

 

2.42         There
is and has been no failure on the part of the Company and any of the Company’s directors or officers, in their capacities
as such, to comply with any provision of the Sarbanes-Oxley Act of 2002 and the rules and regulations promulgated in connection
therewith, including Section 402, related to loans, and Sections 302 and 906, related to certifications.

 

2.43         The
Company and its subsidiaries own, possess, license or otherwise have adequate rights to use, on reasonable terms, all patents,
trademarks, service marks, trade names, copyrights and copyrightable works, licenses, inventions, trade secrets, technology, know-how
(whether or not patentable) and other intellectual property or proprietary rights (including all registrations and applications
for registration of, and all goodwill associated with, the foregoing) (collectively, the “Intellectual Property”)
necessary for the conduct of the Company’s business as now conducted and as proposed in the Final Memorandum to be conducted.
Except as set forth or incorporated by reference in the Preliminary Memorandum and the Final Memorandum or otherwise, the Company
and its subsidiaries would not, singly or in the aggregate, have a Material Adverse Effect: (a) there are no rights of third
parties to any such Intellectual Property; (b) to the Company’s knowledge, there is no material infringement by third
parties of any such Intellectual Property; (c) there is no pending or, to the Company’s knowledge, threatened action,
suit, proceeding or claim by others challenging the Company’s rights in or to any such Intellectual Property, and the Company
is unaware of any facts which would form a reasonable basis for any such claim; (d) there is no pending or, to the Company’s
knowledge, threatened action, suit, proceeding or claim by others challenging the validity or scope of any such Intellectual Property,
and the Company is unaware of any facts which would form a reasonable basis for any such claim; (e) there is no pending or,
to the Company’s knowledge, threatened action, suit, proceeding or claim by others that the Company infringes or otherwise
violates any Intellectual Property or other proprietary rights of others, and the Company is unaware of any other fact which would
form a reasonable basis for any such claim; (f) there is no U.S. patent or published U.S. patent application which contains claims
that have (or may have) priority over or dominate (or may dominate) any Intellectual Property described in the Disclosure Package
and the Final Memorandum as being owned by or licensed to the Company or that interferes with the issued or pending claims of any
such Intellectual Property; and (g) there is no prior art of which the Company is aware that may render any U.S. patent held
by the Company invalid or any U.S. patent application held by the Company unpatentable that has not been disclosed to the U.S.
Patent and Trademark Office.

 

    	 	Annex B-14	 

     

    

 

2.44         Each
of the Company’s directors and executive officers has executed and delivered to the Company a lock-up agreement in the form
of ANNEX G to the Note Purchase Agreement.

 

2.45         The
Company has not engaged any broker, finder, commission agent or other person (other than the Placement Agent) in connection with
the offering and sale of the Notes contemplated hereby or any of the transactions contemplated in the Transaction Agreements, and
the Company is not under any obligation to pay any broker’s fee or commission in connection with such transactions (other
than commissions or fees to the Placement Agent).

 

3.             Representations,
Warranties and Covenants of the Purchasers. Such Purchaser represents and warrants to, and covenants with, the Company, the
Placement Agent and the Closing Agent that:

 

3.1           Purchaser
Status

. Such Purchaser acknowledges
that (a) it meets the definition of “qualified institutional buyers” as defined in Rule 144A(a)(1) under the Securities
Act; and (b) is not an entity formed for the sole purpose of acquiring the Notes. Such Purchaser is not an “affiliate”
of the Company within the meaning of Rule 144 under the Securities Act.

 

3.2           Experience.
(a) Such Purchaser is knowledgeable, sophisticated and experienced in financial and business matters and in making, and is qualified
to make, decisions with respect to investments in shares representing an investment decision like that involved in the purchase
of the Notes (and the Common Stock into which the Notes are potentially convertible), and such Purchaser has undertaken an independent
analysis of the merits and the risks of an investment in the Notes (and the Common Stock into which the Notes are potentially
convertible) and has reviewed carefully the Disclosure Package (and will review carefully the Final Memorandum, as of its date),
based on such Purchaser’s own financial circumstances; (b) such Purchaser understands that its investment in the Notes (and
the Common Stock into which the Notes are potentially convertible) involves a significant degree of risk, including a risk of
total loss of such Purchaser’s investment, and such Purchaser understands that the market price of the Common Stock into
which such Notes are potentially convertible has been volatile and that no representation is being made as to the future value
of the Common Stock; (c) such Purchaser has had the opportunity to request, receive, review and consider all information it deems
relevant in making an informed decision to purchase the Notes (and the Common Stock into which the Notes are potentially convertible)
and to ask questions of, and receive answers from, the Company concerning such information; (d) such Purchaser will comply with
the Securities Act as applicable to it in connection with resales of the Notes, or the Common Stock into which the Notes are convertible,
pursuant to any exemption from the Securities Act; and (e) such Purchaser has, in connection with its decision to purchase the
principal amount of Notes set forth on the signature page to the Note Purchase Agreement, relied solely upon the Disclosure Package
(and the Final Memorandum, as of its date) and the representations and warranties of the Company contained herein, and such Purchaser
has not relied on the Placement Agent or the Closing Agent in negotiating the terms of its investment in the Notes (and the Common
Stock into which the Notes are potentially convertible), and, in making a decision to purchase the Notes (and the Common Stock
into which the Notes are potentially convertible), such Purchaser has not received or relied on any communication, investment
advice or recommendation from the Placement Agent or the Closing Agent.

 

    	 	Annex B-15	 

     

    

 

3.3           Intent.
Such Purchaser is acquiring the principal amount of Notes set forth on the signature page to the Note Purchase Agreement in the
ordinary course of its business and for its own account and with no present intention of distributing any of such Notes or the
Common Stock potentially issuable upon conversion of the Notes or any arrangement or understanding with any other Persons regarding
the distribution of such Notes or Common Stock.

 

3.4           Source
of Funds. Such Purchaser of the Notes will be deemed to have represented and agreed that either (a) such Purchaser is not
a “plan” (as defined in ERISA, and which term includes: (i) “employee benefit plans” (as defined in Section
3(3) of ERISA); (ii) plans, individual retirement accounts and other arrangements that are subject to Section 4975 of the
Internal Revenue Code of 1986, as amended, and the regulations and published interpretations thereunder (the “Code”)
or to provisions under applicable Federal, state, local, non-U.S. or similar laws; and (iii) entities the underlying assets of
which are considered to include “plan assets” of such plans, accounts and arrangements) and it is not purchasing the
Notes on behalf of, or with the “plan assets” of, any “plan” (as so defined); or (b) such Purchaser’s
purchase, holding and subsequent disposition of the Notes either (i) are not a prohibited transaction under ERISA or the Code
and are otherwise permissible under all applicable similar laws or (ii) are entitled to exemptive relief from the prohibited transaction
provisions of ERISA and the Code in accordance with one or more available statutory, class or individual prohibited transaction
exemptions and are otherwise permissible under all applicable similar laws.

 

3.5           Reliance
on Exemptions. Such Purchaser understands that the Notes (and the Common Stock into which the Notes are potentially convertible)
are being offered and sold to it in reliance upon specific exemptions from the registration requirements of the Securities Act,
the rules and regulations promulgated thereunder, and state securities laws and that the Company is relying upon the truth and
accuracy of, and such Purchaser’s compliance with, the representations, warranties, agreements, acknowledgments and understandings
of such Purchaser set forth herein in order to determine the availability of such exemptions and the eligibility of such Purchaser
to acquire the Notes (and the Common Stock into which the Notes are potentially convertible).

 

    	 	Annex B-16	 

     

    

 

3.6           Confidentiality.
For the benefit of the Company, such Purchaser previously agreed to keep confidential all information concerning the private placement
of Notes. Such Purchaser is prohibited from reproducing or distributing the Note Purchase Agreement, the Preliminary Memorandum
and Final Memorandum or any other offering materials or other information provided by the Company in connection with such Purchaser’s
consideration of its investment in the Company, in whole or in part, or divulging or discussing any of their contents, except
to its financial, investment or legal advisors, on a confidential basis, in connection with its proposed investment in the Notes
(and the Common Stock into which the Notes are potentially convertible) or as required by applicable law or regulation. Further,
such Purchaser understands that the existence and nature of all conversations and presentations, if any, regarding the Company
and the offering of Notes must be kept strictly confidential. Such Purchaser understands that the federal securities laws impose
restrictions on trading based on information regarding the offering of Notes. In addition, such Purchaser hereby acknowledges
that unauthorized disclosure of information regarding the offering of Notes may result in a violation of Regulation FD. This obligation
will terminate upon the filing by the Company of the press release or Current Report on Form 8-K referred to in Section 4(a)
below, which shall include any material, non-public information provided to such Purchaser prior to the date hereof. The foregoing
agreements shall not apply to any information that is or becomes publicly available through no fault of such Purchaser, or that
such Purchaser is legally required to disclose; provided, however, that if such Purchaser is requested or ordered
to disclose any such information pursuant to any court or other government order or any other applicable legal procedure, it shall
use its reasonable best efforts to provide the Company with prompt notice of any such request or order in time sufficient to enable
the Company to seek an appropriate protective order.

 

3.7           Investment
Decision. Such Purchaser understands that nothing in the Note Purchase Agreement or any other materials presented to such
Purchaser in connection with the purchase and sale of the Notes (and the Common Stock into which the Notes are potentially convertible)
constitutes legal, tax or investment advice. Such Purchaser has consulted such legal, tax and investment advisors as it, in its
sole discretion, has deemed necessary or appropriate in connection with its purchase of the Notes (and the Common Stock into which
the Notes are potentially convertible).

 

3.8           Legend.
Such Purchaser understands that the Notes and the Common Stock will initially bear the restrictive legends as set forth in the
Indenture and that the Company will make a notation on its records and give instructions to the Trustee and any transfer agent
of the Common Stock in order to implement the restrictions on transfer set forth and described herein.

 

3.9           Residency.
Such Purchaser’s principal executive offices are in the jurisdiction set forth immediately below such Purchaser’s
name on the signature page hereto.

 

    	 	Annex B-17	 

     

    

 

3.10         Organization;
Validity; Enforcements ; Undertaking. (a) Such Purchaser has full right, power and authority to enter into the Note
Purchase Agreement and to consummate the transactions contemplated hereby and has taken all necessary action to authorize the
execution, delivery and performance of the Note Purchase Agreement, (b) the making and performance of the Note Purchase
Agreement by such Purchaser and the consummation of the transactions herein contemplated will not violate any provision of
the organizational documents of such Purchaser or conflict with, result in the breach or violation of, or constitute, either
by itself or upon notice or the passage of time or both, a default under any material agreement, mortgage, deed of trust,
lease, franchise, license, indenture, permit or other instrument to which such Purchaser is a party or, any statute or any
authorization, judgment, decree, order, rule or regulation of any court or any regulatory body, administrative agency or
other governmental agency or body applicable to such Purchaser, (c) no consent, approval, authorization or other order of any
court, regulatory body, administrative agency or other governmental agency or body is required on the part of such Purchaser
for the execution and delivery of the Note Purchase Agreement or the consummation of the transactions contemplated by the
Note Purchase Agreement, (d) upon the execution and delivery of the Note Purchase Agreement, the Note Purchase Agreement
shall constitute a legal, valid and binding obligation of such Purchaser, enforceable in accordance with its terms, except as
such enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or other similar laws or
judicial decisions of general application relating to or affecting the enforcement of creditors’ rights generally and
the application of equitable principles relating to the availability of remedies and except as rights to indemnity or
contribution may be limited by federal or state securities laws or the public policy underlying such laws; (e) there is not
in effect any order enjoining or restraining such Purchaser from entering into or engaging in any of the transactions
contemplated by the Note Purchase Agreement; and (f) each Purchaser undertakes (i) to observe all the requirements of the
Research Law and the provisions of the applicable regulations, rules, procedures and benefit plans, as applied to Protalix
Ltd. and as directed by the research committee of the Israeli Innovation Authority (the “Research
Committee”), in particular those requirements relating to the prohibitions on the transfer of know-how and/or
production rights; and (ii) as a shareholder of the Company, to make all reasonable efforts that Protalix Ltd. shall observe
strictly all the requirements of the Research Law and the provisions of the applicable regulations, rules, procedures and
benefit plans, as applied to Protalix Ltd. and as directed by the Research Committee, in particular those requirements
relating to the prohibitions on the transfer of know-how and/or production rights. Each Purchaser hereby irrevocably
authorizes and empowers the Trustee, the Collateral Agent and the Israeli Security Trustee to execute on its behalf the
standard undertaking in the form requested by the Israeli Innovation Authority.

 

4.             Covenants.
The Company shall:

 

(a)          issue
a press release or file with the Commission a Current Report on Form 8-K publicly disclosing all material non-public information
provided to the Purchasers in connection with the transactions contemplated by the Note Purchase Agreement on or before 9:00 a.m.,
New York City time, on the first business day following the date hereof;

 

(b)          not,
and shall cause each of its subsidiaries and each of their respective officers, directors, employees and agents not to, provide
any Purchaser with any material, non-public information regarding the Company or any of its subsidiaries from and after the issuing
or filing of such press release or current report on Form 8-K, as applicable, pursuant to Section 4(a) above without the
express written consent of such Purchaser;

 

    	 	Annex B-18	 

     

    

 

(c)          not,
during the period ending 90 days after the date hereof, without the prior written consent of the Placement Agent, directly or indirectly,
(i) offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant
any option, right or warrant to purchase, lend or otherwise transfer or dispose of, directly or indirectly, any shares of Common
Stock or any securities convertible into or exercisable or exchangeable for Common Stock; (ii) enter into any swap or other arrangement
that transfers to another, in whole or in part, any of the economic consequences of ownership of the Common Stock or any securities
convertible into or exercisable or exchangeable for Common Stock, whether any such transaction described in clause (i) or (ii)
above is to be settled by delivery of Common Stock or such other securities, in cash or otherwise; (iii) file any registration
statement with the Commission relating to the offering of any shares of Common Stock or any securities convertible into or exercisable
or exchangeable for Common Stock or (iv) publicly announce any intention to take any of the actions specified in clauses (i) through
(iii) above; provided, however, that the foregoing restrictions shall not apply to (A) the issuance of the Notes
pursuant to the Note Purchase Agreement or the Exchange Agreement; (B) the issuance by the Company of any Common Stock or securities
convertible into or exercisable or exchangeable for Common Stock to partners, licensees, consultants and service providers, provided
that (x) the aggregate number of shares of Common Stock issued, or underlying convertible, exercisable or exchangeable securities
issued, pursuant to this clause (B) cannot exceed 5% of the number of shares of Common Stock outstanding as of the execution and
delivery of this Note Purchase Agreement; and (y) each recipient of such Common Stock or other securities must, prior to or concurrently
with receiving, or entering into a definitive agreement to receive, such Common Stock or other securities, execute and deliver
to the Company a lock-up agreement substantially in the form of ANNEX G to this Note Purchase Agreement; (C) the issuance
by the Company of shares of Common Stock upon the exercise of an option or warrant or the conversion of a security outstanding
on the date hereof and disclosed in the Disclosure Package and the Final Placement Memorandum; (D) the granting or exercise of
options or stock purchase rights pursuant to the Company’s stock option and stock purchase plans, whenever granted; or (E)
the issuance of any Common Stock upon the conversion of any Notes in accordance with the Indenture;

 

(d)          on
or prior to the date hereof, have furnished to the Closing Agent each of the lock-up agreements referred to in Section 2.44
above, and such agreements shall be in full force and effect on the Closing Date;

 

(e)          make
all necessary filings required by, and otherwise comply with, all applicable state or foreign securities or “blue sky”
laws in connection with the purchase and sale of Notes contemplated by the Note Purchase Agreement;

 

(f)          file
and take all other actions to perfect such interests as described in the U.S. Security Agreement, the Intellectual Property Security
Agreements (as defined in the U.S. Security Agreement), the IP Charge and the Floating Charge;

 

(g)          cause
all shares of Common Stock, if any, issued upon conversion of the Notes to be listed on each securities exchange, if any, on which
other shares of Common Stock are then listed; and

 

(h)          use
commercially reasonable efforts to obtain shareholder approval to amend its Amended and Restated Articles of Incorporation to increase
the number of authorized shares of Common Stock to an amount that is sufficient to cover any issuances of Common Stock under the
Indenture, assuming Physical Settlement (as defined in the Indenture).

 

    	 	Annex B-19	 

     

    

 

5.             Perfection
in Israel. The Company has authorized Meitar Liquornik Geva Leshem Tal, Israeli counsel for Highbridge Tactical Credit &
Convertibles Master Fund, one of the Purchasers, to submit the documents required in order to (i) file for registration at the
Israeli Registrar of Companies the U.S. Security Agreement, the Intellectual Property Security Agreements (as defined in the U.S.
Security Agreement), the IP Charge and the Floating Charge and (ii) file for registration at the Israeli Registrar of Pledges the
Israeli Stock Pledge, in each case as promptly as possible following the Closing Date, but in any event no later than ten business
days following the Closing Date.

 

6.             Broker’s
Fee. Such Purchaser acknowledges that the Company intends to pay to the Placement Agent a fee in respect of the sale of the
Notes to such Purchaser. Such Purchaser and the Company agree that such Purchaser shall not be responsible for such fee and that
the Company will indemnify and hold harmless such Purchaser against any losses, claims, damages, liabilities or expenses, joint
or several, to which such Purchaser may become subject with respect to such fee. Each of the parties hereto represents that, on
the basis of any actions and agreements by it, there are no other brokers or finders entitled to compensation in connection with
the sale of the Notes to such Purchaser.

 

7.             Independent
Nature of Purchasers’ Obligations and Rights. The obligations of such Purchaser under the Note Purchase Agreement are
several and not joint with the obligations of any other Purchaser, and such Purchaser shall not be responsible in any way for
the performance of the obligations of any other Purchaser under the Note Purchase Agreement. The decision of such Purchaser to
purchase the Notes (and the Common Stock into which the Notes are potentially convertible) pursuant to the Note Purchase Agreement
has been made by such Purchaser independently of any other Purchaser. Nothing contained in the Note Purchase Agreement, and no
action taken by such Purchaser pursuant hereto, shall be deemed to constitute a partnership, an association, a joint venture or
any other kind of entity among such Purchaser and the other Purchasers, or to create a presumption that any of the foregoing are
in any way acting in concert or as a group with respect to such obligations or the transactions contemplated by the Note Purchase
Agreement. Such Purchaser acknowledges that no other Purchaser has acted as agent for such Purchaser in connection with making
its investment hereunder and that no other Purchaser will be acting as agent of such Purchaser in connection with monitoring its
investment in the Notes (and the Common Stock into which the Notes are potentially convertible) or enforcing its rights under
the Note Purchase Agreement. Such Purchaser shall be entitled to independently protect and enforce its rights, including, without
limitation, the rights arising out of the Note Purchase Agreement, and it shall not be necessary for any other Purchaser to be
joined as an additional party in any proceeding for such purpose.

 

8.             Notices.
All notices, requests, consents and other communications hereunder shall be in writing, shall be mailed by first-class registered
or certified airmail, email, confirmed facsimile or nationally recognized overnight express courier postage prepaid and shall
be deemed given when so mailed and shall be delivered as addressed as follows:

 

    	 	Annex B-20	 

     

    

 

(x)          if
to the Company, to:

 

	 	Protalix BioTherapeutics, Inc.
	 	2 Snunit Street, Science Park, POB 455,
	 	Carmiel 20100, Israel
	 	Attention:  Moshe Manor, President and Chief Executive Officer
	 	Facsimile:  972-4-902-8102
	 	Email:  moshe.manor@protalix.com
	 	 
	 	with a copy to:
	 	 
	 	Morrison & Foerster LLP
	 	250 West 55th Street
	 	New York, New York 10019
	 	Attention:  Anna T. Pinedo
	 	Facsimile:  1-212-468-7900
	 	Email:  apinedo@mofo.com

 

(y)          if
to such Purchaser, at its address as set forth on this signature page to the Note Purchase Agreement or at such other address or
addresses as may have been furnished to the Company in writing.

 

9.             Changes.
The Note Purchase Agreement may not be modified or amended as between such Purchaser and the Company except pursuant to an instrument
in writing signed by the Company and such Purchaser. Any amendment or waiver effected in accordance with this Section 9
shall be binding upon the Company and such Purchaser and upon any future holder of any Notes or any shares of Common Stock issued
upon conversion of the Notes (or any successor securities thereto) purchased by such Purchaser pursuant hereto.

 

10.           Survival
of Agreements; Non-Survival of Company Representations and Warranties. Notwithstanding any investigation made by any party
to the Note Purchase Agreement or by the Placement Agent, all covenants and agreements made by the Company and such Purchaser
herein and in the Notes delivered pursuant hereto shall survive the execution of the Note Purchase Agreement, the delivery to
such Purchaser of the Notes being purchased and the payment therefor.

 

11.           Headings.
The headings of the various sections of the Note Purchase Agreement have been inserted for convenience of reference only and shall
not be deemed to be part of the Note Purchase Agreement.

 

12.           Severability.
In case any provision contained in the Note Purchase Agreement should be invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions contained herein shall not in any way be affected or impaired
thereby.

 

    	 	Annex B-21	 

     

    

 

13.           Governing
Law; Venue. The Note Purchase Agreement is to be construed in accordance with the internal laws of the State of New York.
Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in The City of New
York, Borough of Manhattan, for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated
hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim
that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an
inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal
service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such
party at the address for such notices to it under the Note Purchase Agreement and agrees that such service shall constitute good
and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to
serve process in any manner permitted by law. Each party hereby irrevocably waives any right it may have to, and agrees not to
request, a jury trial for the adjudication of any dispute hereunder or in connection with or arising out of the Note Purchase
Agreement or any transaction contemplated hereby. If either party shall commence a proceeding to enforce any provisions of the
Note Purchase Agreement, then the prevailing party in such proceeding shall be reimbursed by the other party for its attorney’s
fees and other costs and expenses incurred with the investigation, preparation and prosecution of such proceeding.

 

14.           Counterparts.
The Note Purchase Agreement may be executed in counterparts, each of which shall constitute an original, but all of which, when
taken together, shall constitute but one instrument, and shall become effective when one or more counterparts have been signed
by each party hereto and delivered to the other parties. Delivery of an executed counterpart of the Note Purchase Agreement by
facsimile transmission or electronic mail in PDF form shall be as effective as delivery of a manually executed counterpart hereof.

 

15.           Entire
Agreement. The Note Purchase Agreement and the instruments referenced herein contain the entire understanding of the parties
with respect to the matters covered herein and therein, and, except as specifically set forth herein or therein, neither the Company
nor such Purchaser makes any representation, warranty, covenant or undertaking with respect to such matters. Each party expressly
represents and warrants that it is not relying on any oral or written representations, warranties, covenants or agreements outside
of the Note Purchase Agreement.

 

16.           Fees
and Expenses. Except as set forth herein and in the Engagement Letter, each of the Company and such Purchaser shall pay its
fees and expenses related to the transactions contemplated by the Note Purchase Agreement.

 

17.           Parties.
The Note Purchase Agreement is made solely for the benefit of and is binding upon such Purchaser and the Company and, to the extent
provided in Section 19 below, any Person controlling the Company or such Purchaser, the officers and directors of the Company
and their respective executors, administrators, successors and assigns. No other Person shall acquire or have any right under
or by virtue of the Note Purchase Agreement, except that each of the Placement Agent and the Closing Agent is an intended third-party
beneficiary of the Note Purchase Agreement (including pursuant to Section 19 below). The term “successors and
assigns” shall not include any subsequent purchaser, as such purchaser, of the Notes sold to such Purchaser pursuant
to the Note Purchase Agreement or any shares of Common Stock issued to such Purchaser upon the conversion of such Notes.

 

    	 	Annex B-22	 

     

    

 

18.           Further
Assurances. Each party agrees to cooperate fully with the other parties and to execute such further instruments, documents
and agreements and to give such further written assurance as may be reasonably requested by any other party to evidence and reflect
the transactions described herein and contemplated hereby and to carry into effect the intents and purposes of the Note Purchase
Agreement.

 

19.           Reliance
by and Exculpation of the Placement Agent and the Closing Agent. Such Purchaser acknowledges that (a) neither the Placement
Agent nor the Closing Agent has made, and neither of them will make, any representations and warranties with respect to the Company
or the offer and sale of the Notes, and such Purchaser will not rely on any statements made by the Placement Agent or the Closing
Agent, orally or in writing, to the contrary; (b) it will be responsible for conducting its own due diligence investigation with
respect to the Company and the offer and sale of the Notes; (c) it will be purchasing Notes based on the results of its own due
diligence investigation of the Company; (d) it has negotiated the offer and sale of the Notes directly with the Company, and neither
the Placement Agent nor the Closing Agent will be responsible for the ultimate success of any such investment; and (e) the decision
to invest in the Notes will involve a significant degree of risk, including a risk of total loss of such investment. Such Purchaser
further represents and warrants that it, including any fund or funds that it manages or advises that participates in the offer
and sale of the Notes, is permitted under its constitutive documents (including, without limitation, all limited partnership agreements,
charters, bylaws, limited liability company agreements, all applicable side letters with investors, and similar documents) to
make investments of the type contemplated by the Note Purchase Agreement. In light of the foregoing, to the fullest extent permitted
by law, each of such Purchaser and the Company releases the Placement Agent, the Closing Agent and their respective employees,
officers and affiliates from any liability with respect to such Purchaser’s participation in the offer and sale of the Notes,
including, but not limited to, any improper payment made in accordance with the information provided by the Company. This Section
19 shall survive any termination of this Note Purchase Agreement. The Placement Agent has introduced such Purchaser to the
Company in reliance on such Purchaser’s understanding and agreement to this Section 19.

 

The parties agree and
acknowledge that the Placement Agent and the Closing Agent may rely on the representations, warranties, agreements and covenants
of the Company contained in the Note Purchase Agreement and may rely on the representations and warranties of the respective Purchasers
contained in the Note Purchase Agreement as if such representations, warranties, agreements and covenants, as applicable, were
made directly to the Placement Agent and the Closing Agent. The parties further agree that the Placement Agent and the Closing
Agent may rely on the legal opinions to be delivered pursuant to Section 1.5(d) or 1.5(e) hereof and the certificates
to be delivered pursuant to Section 1.5(f) or 1.5(g).

 

Each party hereto agrees
for the express benefit of the Placement Agent and the Closing Agent that: (1) neither the Placement Agent nor the Closing Agent,
and none of their respective affiliates or representatives, (A) shall be liable for any improper payment made in accordance with
the information provided by the Company; (B) makes any representation or warranty, or has any responsibilities, as to the validity,
accuracy, value or genuineness of any information, certificates or documentation delivered by or on behalf of the Company pursuant
to the Note Purchase Agreement; or (C) shall be liable (x) for any action taken, suffered or omitted by any of them in good faith
and reasonably believed to be authorized or within the discretion or rights or powers conferred upon it by the Note Purchase Agreement;
or (y) for anything which any of them may do or refrain from doing in connection with the Note Purchase Agreement, except for such
party’s own gross negligence, willful misconduct or bad faith; and (2) the Placement Agent and the Closing Agent, and each
of their respective affiliates and representatives, shall be entitled to (A) rely on, and shall be protected in acting upon, any
certificate, instrument, opinion, notice, letter or any other document or security delivered to any of them by or on behalf of
the Company; and (B) be indemnified by the Company for acting as Placement Agent and Closing Agent, respectively, hereunder.

 

[Remainder
of Page Left Intentionally Blank]

 

    	 	Annex B-23Exhibit 10.2

 

 

 

FORM OF EXCHANGE AGREEMENT

by and among

 

Protalix BioTherapeutics, Inc.

and

the Parties Signatory Hereto

Dated as of December 1, 2016

 

 

 

     

     

    

 

EXCHANGE AGREEMENT dated as of December 1, 2016
(this “Agreement”), by and among Protalix BioTherapeutics, Inc., a Delaware corporation (the “Company”),
and the parties signatory hereto (each, a “Purchaser,” and collectively, the “Purchasers”).

 

BACKGROUND

 

As of the date hereof, Purchasers own and hold
the Company’s 4.50% Convertible Senior Notes due 2018 (the “Existing Notes”) as identified opposite such
Purchaser’s name on Schedule I hereto. The Existing Notes have the covenants and terms set forth in the Indenture
dated as of September 18, 2013 (the “Existing Indenture”), between the Company and The Bank of New York Mellon
Trust Company, N.A., as trustee (the “Trustee”). All capitalized terms used herein that are not otherwise defined
shall have the meanings ascribed to them in the Existing Indenture or the Security Agreement, dated as of December 7, 2016, by
and among the Company, the Guarantors and Wilmington Savings Fund Society, FSB, as Collateral Agent (the “U.S. Security
Agreement”), as applicable.

 

The Company and the Purchasers desire to exchange
(the “Exchange”) Existing Notes for (a) newly issued shares (the “Shares”) of common stock,
par value $0.001 per share, of the Company (the “Common Stock”); (b) newly issued 7.50% Senior Secured Convertible
Notes Due 2021 (the “Exchange Notes”); and (c) cash in the amount of accrued and unpaid interest on such Existing
Notes through, but excluding, the Closing Date (as defined below), in a transaction exempt from registration under the Securities
Act of 1933, as amended (the “Securities Act”), pursuant to the provisions of Section 4(a)(2) thereof.

 

In consideration of the mutual covenants and agreements
contained in this Agreement, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, the
Company and the Purchasers, severally but not jointly, hereby agree as follows:

 

ARTICLE
I

 

SHARE EXCHANGE

 

Section 1.1           Exchange.
The Company agrees to issue to each Purchaser that number of Shares and principal amount of Exchange Notes, and pay to such Purchaser
that amount of cash in U.S. dollars representing accrued and unpaid interest on the Existing Notes of such Purchaser, set forth
on Schedule I hereto opposite such Purchaser’s name in exchange for Existing Notes of such Purchaser having the aggregate
principal set forth on Schedule I hereto opposite such Purchaser’s name, and such Purchaser, severally and not jointly,
agrees to exchange all such Existing Notes for such Shares, Exchange Notes and cash. For each $1,000 principal amount of Existing
Notes exchanged by a Purchaser participating in the Concurrent Private Placement (as defined below), such Purchaser will receive
(a) $775 aggregate principal amount of Exchange Notes (which, based on the total principal amount of Exchange Notes issuable to
such Person, will be rounded up to the nearest $1,000 in principal amount, if applicable), (b) $250 in Shares, based on $0.5595
per share of Common Stock, which is the last reported consolidated closing bid price available as of the time of execution of this
Agreement (the “Closing Sale Price”), and (c) $10.25 in cash for accrued
and unpaid interest on such Exchange Notes (together, the “Participating Exchange Consideration”); provided,
however, that, based on the aggregate principal amount of Existing Notes exchanged by such Purchaser pursuant to this Agreement,
the Company will pay such Purchaser cash in lieu of any fractional share otherwise due pursuant to clause (b) above, based on the
Closing Sale Price. For each $1,000 principal amount of Existing Notes exchanged by a Purchaser not participating in the Concurrent
Private Placement, such Purchaser will receive (x) $525 aggregate principal amount of Exchange Notes (which, based on the total
principal amount of Exchange Notes issuable to such Person, will be rounded up to the nearest $1,000 in principal amount, if applicable),
(y) $225 in Shares, based on the Closing Sale Price, and (z) $10.25 in cash for accrued and
unpaid interest on such Exchange Notes (together, the “Non-Participating Exchange Consideration”); provided,
however, that, based on the aggregate principal amount of Existing Notes exchanged by such Purchaser pursuant to this Agreement,
the Company will pay such Purchaser cash in lieu of any fractional share otherwise due pursuant to clause (y) above, based on the
Closing Sale Price.

 

    	 	1	 

     

    

 

Section 1.2           Exchange
Procedures.

 

(a)          The
closing of the Exchange (the “Closing”) will be held on the third Business Day (as defined herein) following
the date hereof (the “Closing Date”). No later than 10:00 a.m., New York City time, on the Closing Date, each
Purchaser shall cause its custodian through which the Purchaser holds its Existing Notes to post a DWAC request to the Trustee
(i) to effect the transfer of the Existing Notes in accordance with the procedures of The Depository Trust Company (“DTC”),
into a book-entry account established by or on behalf of the Company, and to use commercially reasonable efforts to ensure that
the Trustee receives an agent’s message from DTC confirming the book-entry transfer of the Existing Notes, and (ii) for free
receipt to the Trustee for such Purchaser’s Shares and aggregate principal amount of Exchange Notes opposite such Purchaser’s
name on Schedule I hereto. The delivery of the Existing Notes by each Purchaser will be complete upon receipt by the Trustee
on the Closing Date of an agent’s message, book-entry confirmation from DTC and any other required documents.

 

(b)          On
the Closing Date, the Company, or Trustee at the Company’s direction, will (i) cause the Shares and Exchange Notes to be
credited to the DTC accounts identified opposite such Purchaser’s name on Schedule I hereto against delivery of the
Existing Notes and (ii) cause the payment of cash for accrued interest owed on the Existing Notes through, but excluding, the Closing
Date, and in lieu of any fractional shares, as set forth on Schedule I hereto, by wire transfer of immediately available
funds to the accounts previously provided in writing by such Purchaser. For the avoidance of doubt, Purchasers shall cease to own
any Existing Notes as of the crediting of the Shares and Exchange Notes to the DTC accounts identified on Schedule I hereto
and the payment of cash in lieu of any fractional shares and for accrued interest on the Existing Notes by wire transfer as provided
in the immediately preceding sentence, and the Company shall be entitled to instruct the appropriate parties to immediately thereafter
cancel the Existing Notes on the books and records of the Company.

 

    	 	2	 

     

    

 

ARTICLE
II

 

REPRESENTATIONS AND WARRANTIES OF THE COMPANY

 

The Company represents and warrants to, and agrees
with, each Purchaser, as of the date hereof and as of the Closing Date, as follows:

 

Section 2.1           Existence
and Power. The Company is a duly organized and validly existing corporation in good standing under the laws of the State of
Delaware and has the corporate power and authority to own its properties and conduct its business as currently conducted. The Company’s
subsidiaries identified on Schedule II hereto are duly organized and validly existing in good standing under the laws of
their respective jurisdictions of organization and have the organizational power and authority to hold their respective properties
and conduct their businesses as currently conducted. The Company does not have any “significant subsidiary” as defined
in Rule 1-02 of Regulation S-X that is not listed on Schedule II hereto.

 

Section 2.2           Authorization
and Enforceability. The execution, delivery and performance of this Agreement and each other document, instrument or agreement
executed and delivered by the Company in connection with the transactions contemplated hereby has been duly authorized by all necessary
action on the part of the Company, and this Agreement and each other document, instrument or agreement executed and delivered by
the Company in connection with the transactions contemplated hereby, when duly executed and delivered by the parties hereto and
thereto, will be the legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its
terms (subject, as to the enforcement of remedies, to applicable bankruptcy, reorganization, insolvency, moratorium or other laws
affecting creditors’ rights generally from time to time in effect and to general principles of equity).

 

Section 2.3           Capitalization.
All issued and outstanding shares of Common Stock have been duly authorized and validly issued and are fully paid and nonassessable,
and none of the outstanding shares of Common Stock were issued in violation of any preemptive or similar rights of any securityholder
of the Company. The issued and outstanding shares of capital stock or other equity interests of each of the Company’s subsidiaries
have been duly authorized and validly issued, are fully paid and nonassessable and are owned by the Company free and clear of any
security interests, liens, encumbrances, equities or claims of any third party.

 

Section 2.4           Valid
Issuance of Shares. The Shares have been duly authorized for issuance by all necessary corporate action and, when issued in
accordance with the terms hereof, the Shares will be validly issued, fully paid and nonassessable; and the Shares are not being
issued in violation of any preemptive or other similar rights of any securityholder of the Company.

 

    	 	3	 

     

    

 

Section 2.5           Valid
Issuance of Exchange Notes; Enforceability of Notes and Indenture. The Exchange Notes have been duly executed by the Company
and, when authenticated by the Trustee in accordance with the indenture by and between the Company and the other parties identified
therein (the “Indenture”), and delivered and paid for as provided herein, will be the legal, valid and binding
obligations of the Company, enforceable against the Company in accordance with their terms and entitled to the benefits of the
Indenture (subject, as to the enforcement of remedies, to applicable bankruptcy, reorganization, insolvency, moratorium or other
laws affecting creditors’ rights generally from time to time in effect and to general principles of equity); the maximum
number shares of Common Stock initially issuable upon conversion of the Exchange Notes (including the maximum number of additional
shares that may be issued in connection with a “Make-Whole Adjustment Event,” assuming (x) all conversions are settled
solely in shares of Common Stock and (y) the Authorized Share Amendment Effective Date (as defined in the Indenture) has occurred)
(the “Maximum Number of Shares”) will be, after the Authorized Share Amendment Effective Date (as defined in the Indenture),
duly authorized and, when issued upon conversion of the Exchange Notes in accordance with the Indenture, will be validly issued,
fully paid and nonassessable; the Indenture has been duly authorized and, assuming due authorization, execution and delivery thereof
by the Trustee, when executed and delivered by the Company, will constitute a legal, valid, binding instrument enforceable against
the Company in accordance with its terms (subject, as to the enforcement of remedies, to applicable bankruptcy, reorganization,
insolvency, moratorium or other laws affecting creditors’ rights generally from time to time in effect and to general principles
of equity); the Board of Directors of the Company has duly and validly adopted resolutions reserving such shares of Common Stock
for issuance upon conversion of the Exchange Notes; and such shares of Common Stock are not subject to any preemptive or similar
right.

 

Section 2.6           Secured
Party Rights.

 

(a)          Protalix
Ltd. is authorized to pledge to Altshuler Shaham Trust Ltd., as security trustee, for the benefit of the Trustee (on behalf of
the Purchasers), a security interest in all (or portion) of its assets, subject to the approval of the Israeli National Authority
for Technological Innovation (the “Israeli Innovation Authority”) and in accordance with the provisions of the
Israeli Encouragement of Research, Development and Technological Innovation in Industry Law, 5744-1984 (the “Research
Law”); and

 

(b)          the
Company is authorized to pledge to the Collateral Agent, for the ratable benefit of the Secured Parties, a security interest in
all of the property set forth in Section 3 of the U.S. Security Agreement, in accordance with the terms and provisions of the U.S.
Security Agreement.

 

Section 2.7           Non-Contravention/No
Consents. Other than as stipulated in Section 2.6 above, the execution and delivery of this Agreement, the Indenture and the
Notes, the consummation of the transactions herein and therein contemplated, and the fulfillment of the terms hereof and thereof,
will not conflict with, result in a breach or violation or imposition of any lien, charge or encumbrance upon any property or assets
of the Company or any of its subsidiaries pursuant to, (a) the charter or by-laws or comparable constituting documents of the Company
or any of its subsidiaries; (b) the terms of any indenture, contract, lease, mortgage, deed of trust, note agreement, loan agreement
or other agreement, obligation, condition, covenant or instrument to which the Company or any of its subsidiaries is a party or
bound or to which its or their property is subject; or (c) any statute, law, rule, regulation, judgment, order or decree of any
court, regulatory body, administrative agency, governmental body, arbitrator or other authority having jurisdiction over the Company
or any of its subsidiaries or any of its or their properties, except, in the cases of clauses (b) and (c), as would not, singly
or in the aggregate, have a material adverse effect on the condition (financial or otherwise), prospects, earnings, business or
properties of the Company and its subsidiaries, taken as a whole, whether or not arising from transactions in the ordinary course
of business (a “Material Adverse Effect”). No stockholder approval is required under the rules of the NYSE MKT
LLC (“NYSE MKT”) in connection with the issuance of the Exchange Notes.

 

    	 	4	 

     

    

 

Section 2.8           SEC
Reports. The Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2015, as amended, and all other
reports filed by the Company with the Securities and Exchange Commission (the “SEC”) pursuant to Section 13(a),
Section 14 or Section 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), since December
31, 2015 and prior to the date hereof (collectively, the “Reports”), when they were filed with the SEC, complied
as to form in all material respects with the applicable requirements under the Exchange Act, and did not, when such Reports were
so filed, contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary
in order to make the statements therein, in the light of the circumstances under which they were made, not misleading.

 

Section 2.9           No
Brokers. Neither the Company nor any of its subsidiaries nor any of their respective officers, directors, employees or agents
has incurred any liability for any commissions or other remuneration in connection with the Exchange, other than pursuant to that
certain Engagement Letter, dated as of November 3, 2016, between Jefferies LLC (the “Jefferies”) and the Company
(the “Engagement Letter”).

 

Section 2.10         Section
4(a)(2) Exemption. It is not necessary in connection with the Exchange, in the manner contemplated herein, to register the
issuance of the Shares and Exchange Notes under the Securities Act in reliance on the exemption from registration set forth under
Section 4(a)(2) of the Securities Act. The Company or any person acting on its behalf has not offered or sold the Exchange Notes
or the Shares by means of any general solicitation or general advertising or in any manner involving a public offering within the
meaning under Section 4(a)(2) of the Securities Act.

 

Section 2.11         No
Restrictions on Sale. Assuming the accuracy of the Purchasers’ representations and warranties hereunder, the Shares and
the Exchange Notes will, as of the Closing Date, be free of any restrictive legend or other restrictions on resale by the Company
and will be issued in book-entry form, represented by permanent global certificates deposited with, or on behalf of, The Depositary
Trust Company represented by the unrestricted CUSIP assigned to the Company’s Common Stock.

 

Section 2.12         Properties.
Each of the Company and its subsidiaries owns or leases all such properties as are reasonably necessary to the conduct of its operations
as presently conducted.

 

    	 	5	 

     

    

 

Section 2.13         Intellectual
Property. The Company and its subsidiaries own, possess, license or otherwise have adequate rights to use, on reasonable terms,
all patents, trademarks, service marks, trade names, copyrights and copyrightable works, licenses, inventions, trade secrets, technology,
know-how (whether or not patentable) and other intellectual property or proprietary rights (including all registrations and applications
for registration of, and all goodwill associated with the foregoing) (collectively, the “Intellectual Property”)
necessary for the conduct of the Company’s business as now conducted. None of the events, singly or in the aggregate, have
a Material Adverse Effect: (a) there are no rights of third parties to any such Intellectual Property except as disclosed
in the Reports; (b) to the Company’s knowledge, there is no material infringement by third parties of any such Intellectual
Property; (c) there is no pending or, to the Company’s knowledge, threatened action, suit, proceeding or claim by others
challenging the Company’s rights in or to any such Intellectual Property, and the Company is unaware of any facts which would
form a reasonable basis for any such claim; (d) there is no pending or, to the Company’s knowledge, threatened action, suit,
proceeding or claim by others challenging the validity or scope of any such Intellectual Property, and the Company is unaware of
any facts which would form a reasonable basis for any such claim; (e) there is no pending or, to the Company’s knowledge,
threatened action, suit, proceeding or claim by others that the Company infringes or otherwise violates any Intellectual Property
or other proprietary rights of others, and the Company is unaware of any other fact which would form a reasonable basis for any
such claim; (f) there is no U.S. patent or published U.S. patent application which contains claims that have (or may have) priority
over or dominate (or may dominate) any Intellectual Property owned by or licensed to the Company or that interferes with the issued
or pending claims of any such Intellectual Property; and (g) there is no prior art of which the Company is aware that may
render any U.S. patent held by the Company invalid or any U.S. patent application held by the Company unpatentable which has not
been disclosed to the U.S. Patent and Trademark Office.

 

ARTICLE
III

 

REPRESENTATIONS AND WARRANTIES OF THE PURCHASERS

 

Each Purchaser, severally but not jointly, represents
and warrants to, and agrees with, the Company, as of the date hereof and as of the Closing Date, as follows:

 

Section 3.1           Existence
and Power; Capitalization. The Purchaser is duly organized and validly existing under the laws of the jurisdiction of its organization
and has all requisite power and authority to enter into and perform its obligations under this Agreement.

 

Section 3.2           Authorization.
The execution, delivery and performance of this Agreement and each other document, instrument or agreement executed and delivered
by such Purchaser in connection with the transactions contemplated hereby has been duly authorized by all necessary action on the
part of the Purchaser, and this Agreement and each other document, instrument or agreement executed and delivered by such Purchaser
in connection with the transactions contemplated hereby, when duly executed and delivered by the parties hereto and thereto, is
a valid and binding obligation of the Purchaser, enforceable against it in accordance with its terms (subject, as to the enforcement
of remedies, to applicable bankruptcy, reorganization, insolvency, moratorium or other laws affecting creditors’ rights generally
from time to time in effect and to general principles of equity). The Purchaser has the full right, power, legal capacity and authority
to sell and transfer the Existing Notes and to enter into and perform its obligations under this Agreement.

 

    	 	6	 

     

    

 

Section 3.3           Governmental
Authorization. As of the date hereof, no permit, authorization, consent or approval of or by, or any notification of or filing
with, any Person (governmental or private) is required to be obtained or made by the Purchaser in connection with the execution,
delivery and performance by it of this Agreement, the consummation by it of the transactions contemplated hereby or thereby, or
the issuance or delivery to it by the Company of the Shares and Exchange Notes, other than a filing on a Schedule 13G or 13D (or
13G/A or 13D/A), if applicable.

 

Section 3.4           Non-Contravention/No
Consents. The execution, delivery and performance of this Agreement will not conflict with, violate or result in a breach of
any provision of, or constitute a default under, or result in the termination of or accelerate the performance required by (a)
any provision of the organizational documents of the Purchaser, (b) any mortgage, note, indenture, deed of trust, loan agreement
or other agreement or instrument to which the Purchaser is a party or by which the Purchaser is bound or to which any of the property
or assets of the Purchaser is subject; or (c) any law, statute, rule, regulation, judgment, order, writ or decree of any arbitrator,
court, governmental body, regulatory body, or administrative agency having jurisdiction over the Purchaser or any of its properties
or assets, other than any such conflict, violation, breach, default, termination and acceleration under clauses (b) and (c) that
would not reasonably be expected to materially adversely impact the ability of the Purchaser to consummate the transactions contemplated
hereby.

 

Section 3.5           No
Brokers. The Purchaser has not employed any broker or finder in connection with the transactions contemplated by this Agreement.

 

Section 3.6           Purchaser
Status. Such Purchaser acknowledges that (a) it meets the definition of “qualified institutional buyers” as defined
in Rule 144A(a)(1) under the Securities Act; and (b) is not an entity formed for the sole purpose of acquiring the Notes. Such
Purchaser is not an “affiliate” of the Company within the meaning of Rule 144 under the Securities Act.

 

Section 3.7           Company
Information. The Purchaser represents that in connection with this Agreement and the Exchange contemplated hereby it is relying
solely on the information relating to the Company’s business, finances and operations contained in the Reports and further
acknowledges that the Company makes no representation or warranty with respect to any matters relating to the Company, its business,
financial condition, results of operations, prospects or otherwise, except to the extent expressly provided in Article II hereof.

 

Section 3.8           The
Purchaser undertakes (a) to observe all the requirements of the Research Law and the provisions of the applicable regulations,
rules, procedures and benefit plans, as applied to Protalix Ltd. and as directed by the research committee of the Israeli Innovation
Authority (the “Research Committee”), in particular those requirements relating to the prohibitions on the transfer
of know-how and/or production rights; and (b) as a stockholder of the Company, to make all reasonable efforts to cause Protalix
Ltd. to observe strictly all the requirements of the Research Law and the provisions of the applicable regulations, rules, procedures
and benefit plans, as applied to Protalix Ltd. and as directed by the Research Committee, in particular those requirements relating
to the prohibitions on the transfer of know-how and/or production rights. Each Purchaser hereby irrevocably authorizes and empowers
the Trustee, the Collateral Agent and Altshuler Shaham Trust Ltd. (as security trustee under the Israeli law governed Security
Documents) to execute on its behalf the standard undertaking in the form requested by the Israeli Innovation Authority.

 

    	 	7	 

     

    

 

Section 3.9           Risks
of Investment. The Purchaser fully understands the risks relating to an investment in the Shares and Exchange Notes. The Purchaser
is able to bear the economic risk of holding the Exchange Notes and Shares for an indefinite period (including total loss of its
investment), and has sufficient knowledge and experience in financial and business matters so as to be capable of evaluating the
merits and risk of its investment.

 

Section 3.10         No
Encumbrances. The Purchaser is the sole and exclusive holder of the Existing Notes free and clear of all liens, pledges, hypothecations,
claims, restrictions or encumbrances, and no other person, firm or corporation has any interest whatsoever in the Existing Notes
(other than pledges or security interests that the Purchaser may have created in favor of a prime broker under and in accordance
with its prime brokerage agreement with such broker). The Exchange provided for herein will vest in the Company valid and absolute
title to the Existing Notes, free and clear of any and all encumbrances, liens, pledges, hypothecations, restrictions, claims,
options, agreements and conditions.

 

Section 3.11         Section
4(a)(2) Exemption. The Purchaser acknowledges that in connection with the Exchange, in the manner contemplated herein, the
Company intends to rely on the exemption from registration set forth under Section 4(a)(2) of the Securities Act. The Purchaser
knows of no reason why such exemption is not available.

 

Section 3.12         Investment
Purpose. The Purchaser is acquiring the Exchange Notes and Shares solely for its own account for investment purposes and not
with a view to, or for offer or sale in connection with, any distribution thereof. The Purchaser acknowledges that the offer and
sale of the Exchange Notes and the Shares are not registered under the Securities Act, or any state securities laws, and that the
Exchange Notes and Shares may not be transferred or sold except pursuant to the registration provisions of the Securities Act or
pursuant to an applicable exemption therefrom and subject to state securities laws and regulations, as applicable.

 

Section 3.13         No
View to Effecting Exchange. The Purchaser did not acquire the Existing Notes with a view to effecting the Exchange.

 

Section 3.14         Holding
Period. The Purchaser has beneficially owned the Existing Notes being exchanged by such Purchaser in the Exchange continuously
for a period of at least one year within the meaning of Rule 144(d) under the Securities Act.

 

Section 3.15         Concurrent
Private Placement. The Purchaser acknowledges that, concurrently with the Exchange, the Company is conducting a private placement
for cash of up to $35 million aggregate principal amount of securities of the same class as the Exchange Notes (the “Concurrent
Private Placement”).

 

Section 3.16         Reliance.
The Purchaser acknowledges that the Company will rely upon the truth and accuracy of the foregoing representations and warranties.

 

    	 	8	 

     

    

 

ARTICLE
IV

 

CLOSING CONDITIONS

 

Section 4.1           Conditions
to the Company’s Obligations. The Company’s obligation to complete the Exchange at the Closing shall be subject
to the following conditions, any one or more of which may be waived by the Company:

 

(a)          receipt
by the Company of the Existing Notes being exchanged hereunder and satisfaction by each Purchaser of all of its obligations contemplated
by this Agreement in connection with the Exchange;

 

(b)          completion
of the Concurrent Private Placement;

 

(c)          the
accuracy of the representations and warranties made by the Purchasers in this Agreement; and

 

(d)          no
injunction, restraining order, action or order of any nature by a governmental or regulatory authority shall have been issued,
taken or made and no action shall have been taken and no statute, rule, regulation or order shall have been enacted, adopted or
issued by any federal, state or foreign governmental or regulatory authority of competent jurisdiction that would, prior to or
as of the Closing Date, prevent or materially interfere with the consummation of the transactions contemplated by this Agreement.

 

Section 4.2           Conditions
to the Purchasers’ Obligations. Each Purchaser’s obligation to complete the Exchange at the Closing shall be subject
to the following conditions, any one or more of which may be waived by such Purchaser:

 

(a)          completion
of the Concurrent Private Placement;

 

(b)          the
Common Stock shall continue to be listed on the NYSE MKT as of the Closing Date; there shall have been no suspensions in the trading
of the Common Stock as of the Closing Date; and the listing of additional shares notification form with respect to the Maximum
Number of Shares shall have been submitted to NYSE MKT and NYSE MKT shall have confirmed that it has no objection to such notification;
and

 

(c)          no
injunction, restraining order, action or order of any nature by a governmental or regulatory authority shall have been issued,
taken or made and no action shall have been taken and no statute, rule, regulation or order shall have been enacted, adopted or
issued by any federal, state or foreign governmental or regulatory authority of competent jurisdiction that would, prior to or
as of the Closing Date, prevent or materially interfere with the consummation of the transactions contemplated by this Agreement.

 

    	 	9	 

     

    

 

ARTICLE
V

 

MISCELLANEOUS

 

Section 5.1           Definitions.

 

(a)          As
used herein, the following terms have the following meanings:

 

“Business Day”
means any day other than a Saturday, a Sunday or a day on which the Federal Reserve Bank of New York, Wilmington, Delaware or the
place of payment is authorized or required by law or executive order to close or be closed.

 

“Person” or “person”
shall mean an individual, corporation, association, partnership, trust, joint venture, business trust or unincorporated organization,
or a government or any agency or political subdivision thereof.

 

Section 5.2           NYSE
MKT Listing. The Company shall use its commercially reasonable efforts to cause all Shares and Common Stock issuable upon conversion
of the Exchange Notes issued hereunder, upon official notice of issuance, to be listed on the NYSE MKT on the Closing Date, or
such other date as mutually agreed to in writing by the parties hereto.

 

Section 5.3           Notices.
All notices and other communications required or permitted to be given under this Agreement shall be in writing and shall be deemed
to have been given if delivered personally or by facsimile or three Business Days after having been sent by certified mail, return
receipt requested, postage prepaid, to the parties to this Agreement at the following address or to such other address either party
to this Agreement shall specify by notice to the other party:

 

(i)           If
to the Company:

Protalix BioTherapeutics, Inc.

2 Snunit Street, Science Park, POB 455,

Carmiel 20100, Israel

Attention: Moshe Manor, President and
Chief Executive Officer.

Facsimile: 972-4-902-8102

E-mail: moshe.manor@protalix.com

 

with a copy to (which shall not constitute
notice):

 

Morrison & Foerster LLP

250 West 55th Street

New York, New York 10019

Attention: Anna T. Pinedo

Facismile: 1-212-468-7900

E-mail: apinedo@mofo.com

 

(ii)         if
to such Purchaser, at its address as set forth on the signature page to this Agreement or such other address as may have been previously
furnished to the Company in writing.

 

Section 5.4           Further
Assurances. Each party hereto shall do and perform or cause to be done and performed all further acts and shall execute and
deliver all other agreements, certificates, instruments and documents as the other party hereto reasonably may request in order
to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby.

 

    	 	10	 

     

    

 

Section 5.5           Amendments
and Waivers.

 

(a)           Any provision of this Agreement may be
amended or waived if, but only if, such amendment or waiver is in writing and is duly executed and delivered by the Company and
Purchasers.

 

(b)          No
failure or delay by any party in exercising any right, power or privilege hereunder shall operate as a waiver thereof nor shall
any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, power
or privilege. The rights and remedies herein provided shall be cumulative and not exclusive of any rights or remedies provided
by law.

 

Section 5.6           Fees
and Expenses. Except as set forth in the Engagement Letter, each party hereto shall pay all of its own fees and expenses (including
attorneys’ fees) incurred in connection with this Agreement and the transactions contemplated hereby.

 

Section 5.7           Successors
and Assigns. The provisions of this Agreement shall be binding upon and inure to the benefit of the parties hereto and their
respective successors and assigns, provided that neither party may assign, delegate or otherwise transfer any of its rights or
obligations under this Agreement without the prior written consent of the non-assigning party hereto. Notwithstanding the previous
sentence, each Purchaser may assign its rights and obligations under this Agreement to one or more of the Purchaser’s wholly
owned subsidiaries that agrees in writing with the Company to be bound by the terms and provisions of this Agreement to the same
extent as the Purchaser, but no such assignment shall relieve the Purchaser of its obligations hereunder.

 

Section 5.8           Governing
Law. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

Section 5.9           Jurisdiction;
Waiver of Jury Trial.

 

(a)          The
parties hereto agree that any suit, action or proceeding seeking to enforce any provisions of, or based on any matter arising out
of or in connection with, this Agreement and the transactions contemplated hereby may only be brought in the United States District
Court for the Southern District of New York or any New York State court sitting in the Borough of Manhattan in New York City, and
each of the parties hereby consents to the jurisdiction of such courts (and of the corresponding appellate courts) in any such
suit, action or proceeding and irrevocably waives, to the fullest extent permitted by law, any objection which it may now or hereafter
have to the venue of any such suit, action or proceeding in any of those courts or that any such suit, action or proceeding which
is brought in any of those courts has been brought in an inconvenient forum. Process in any such suit, action or proceeding may
be served on any party anywhere in the world, whether within or without the jurisdiction of any such court.

 

    	 	11	 

     

    

 

(b)          THE
PARTIES HERETO HEREBY IRREVOCABLY WAIVE ANY AND ALL RIGHTS TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATED TO
THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

 

Section 5.10         Entire
Agreement. This Agreement constitutes the entire agreement between the parties hereto with respect to the subject matter of
this Agreement and supersedes all prior agreements and understandings, both oral and written, between the parties hereto with respect
to the subject matter of this Agreement.

 

Section 5.11         Effect
of Headings. The Article and Section headings herein are for convenience only and shall not affect the construction hereof.

 

Section 5.12         Severability.
If one or more provisions of this Agreement are held to be unenforceable under applicable law, such provision shall be deemed to
be excluded from this Agreement and the balance of this Agreement shall be interpreted as if such provision were so excluded and
shall be enforced in accordance with its terms to the maximum extent permitted by law.

 

Section 5.13         Public
Announcements. Subject to each party’s disclosure obligations imposed by law, each of the parties hereto agree that the
terms of this Agreement shall not be disclosed or otherwise made available to the public and that copies of this Agreement shall
not be publicly filed or otherwise made available to the public. 

 

Section 5.14         Counterparts;
Third Party Beneficiaries. This Agreement may be signed in any number of counterparts, each of which shall be an original,
with the same effect as if the signatures were upon the same instrument. No provision of this Agreement shall confer upon any Person
other than the parties hereto any rights or remedies hereunder; provided, however, that Jefferies will be deemed
to be a third party beneficiary of this Agreement to the extent provided in Section 5.19.

 

Section 5.15         Withholding.
On the date hereof (and at any other time or times prescribed by applicable law or as reasonably requested by the Company), each
Purchaser shall deliver to the Company a properly completed and duly executed IRS Form W-9 , Form W-8BEN, W-8BEN-E or other appropriate
Form W-8 (or successor form), together with any other information necessary in order to establish an exemption from, or a reduced
rate of, U.S. federal income tax withholding, and except to the extent that an exemption or reduction is properly established,
all payments to be made by the Company in respect of the Shares and Exchange Notes shall be made net of deduction or withholding
for or on account of taxes as required by applicable law. Each Purchaser shall promptly notify the Company if at any time such
previously delivered IRS forms or information are no longer correct or valid.

 

Section 5.16         Isolated
Recapitalization. The Company and Purchasers intend that, for U.S. federal income tax purposes, the Exchange qualify as a plan
of reorganization and as an isolated transaction that is a recapitalization within the meaning of Section 368(a)(1)(E) of the Code.

 

    	 	12	 

     

    

 

Section 5.17         Other
Transactions. The Company represents to each Purchaser that the Company has not (a) agreed or entered into any arrangements
with any holder of Existing Notes to exchange such Existing Notes for other securities or other consideration, other than pursuant
to the Exchange and this Agreement; or (b) agreed or entered into any arrangements with any Purchaser to provide for the exchange
of such Purchaser’s Existing Notes on terms that differ from the terms set forth in this Agreement; provided, however,
that nothing in this Section 5.17 will affect the Company’s ability to effect any future exchange of any of its securities
on terms that may differ from the terms set forth in this Agreement.

 

Section 5.18         Miscellaneous.
For the avoidance of doubt, each representation, warranty, obligation and covenant of each Purchaser herein relates solely to that
Purchaser and no Purchaser shall be liable for the inaccuracy of any representation or warranty or any breach of any obligation
or covenant of another Purchaser hereunder.

 

Section 5.19         Exculpation
of and Reliance by Jefferies. Each Purchaser acknowledges that Jefferies is acting as an advisor to the Company in connection
with the transactions contemplated by this Agreement. Each Purchaser acknowledges that (a) Jefferies has not made, and it will
not make, any representations and warranties with respect to the Company or the Exchange, and such Purchaser will not rely on any
statements made by Jefferies, orally or in writing, to the contrary; (b) it has negotiated the terms of the Exchange directly with
the Company, and Jefferies will not be responsible for the ultimate success of any investment in the Shares or the Exchange Notes;
and (c) the decision to participate in the Exchange will involve a significant degree of risk, including a risk of total loss of
such investment. In light of the foregoing, to the fullest extent permitted by law, each of the Purchasers and the Company releases
Jefferies and its employees, officers and affiliates from any liability with respect to the Purchaser’s participation in
the Exchange. Each of the Purchasers and the Company agrees and acknowledges that Jefferies may rely on the representations, warranties,
agreements and covenants of the Purchasers and the Company contained in this Agreement as if such representations, warranties,
agreements and covenants were made directly to Jefferies. This Section 5.19 will survive any termination of this Agreement.

 

[The remainder of this
page is intentionally left blank]

 

    	 	13	 

     

    

 

IN WITNESS WHEREOF, the parties hereto have caused
this Agreement to be duly executed by their respective authorized officers as of the day and year first above written.

 

	 	PROTALIX BIOTHERAPEUTICS, INC.
	 	 
	 	By:	 
	 	Name:
	 	Title:

 

[Signature Page to Exchange Agreement]

 

     

     

    

 

Print or Type:

 

	 	 
	 	Name of Purchaser
	 	(Individual or Institution)
	 	 
	 	 
	 	Jurisdiction of Purchaser’s Executive Offices
	 	 
	 	 
	 	Name of Individual representing Purchaser (if an Institution)
	 	 
	 	 
	 	Title of Individual representing Purchaser (if an Institution)

 

	Signature by:	Individual Purchaser or Individual representing Purchaser:
	 	 
	 	 

 

	 	Address:	 
	 	 	 
	 	Telephone:	 
	 	 	 
	 	Facsimile:	 
	 	 	 
	 	Email:	 

 

NOMINEE/CUSTODIAN (Name in which the
Notes and, if applicable, Common Stock issued upon conversion of the Notes are to be registered if different than name of Purchaser):_________

 

	DTC Number:	 
	 	 
	Tax I.D. Number or Social Security Number:	 
	(If acquired in the name of a nominee/custodian, the taxpayer I.D. number of such nominee/custodian)

  

*** Please note that if you are sub-allocating
to multiple funds,

you must execute a signature page for each fund.
***

  

[Signature Page to Exchange Agreement]

 

     

     

    

 

Schedule I

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00265-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00265-of-00352.parquet"}]]