Document:

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                                                                   Exhibit 10.1

                        EXECUTIVE EMPLOYMENT AGREEMENT
                        ------------------------------

     This Executive Employment Agreement is made as of this eighth day of
January, 2000, by and between Focal Communications Corporation and its
Subsidiaries, a Delaware corporation (the "Company") and Michael L. Mael whose
address is 9 Winterset Court, Potomac, MD 20854 (the "Executive").

     WHEREAS, the Company and the Executive wish to enter into an agreement for
employment which shall provide certain terms of employment. The parties
acknowledge that all terms of employment may not be contained in this Agreement,
but that as to other conflicting terms of employment, which may be initiated
from time to time by the Company, the terms contained herein, or as amended from
time to time by the parties hereto, shall control.

     NOW THEREFORE, in accordance with the premise above, the parties agree as
follows:

     1.   Terms of Executive's Employment.
          -------------------------------

          (a)  Employment. The Company hereby employs Executive, and Executive
               ----------
               hereby accepts employment and agrees to perform his duties and
               responsibilities hereunder, in accordance with the terms and
               conditions hereinafter set forth. The Company shall have the
               right to terminate the Executive's employment for any reason, at
               any time, with or without Cause (defined below). Executive shall
               have the right to terminate his employment for any reason,
               including Good Reason (as hereinafter defined), at any time, upon
               giving the Company written notice two weeks prior to such
               termination.

          (b)  Duties and Responsibilities.
               ---------------------------

               (i)  Initially, the Executive shall serve as Executive Vice
                    President of the Company and the President of [subsidiary],
                    and so long as Executive is employed by the Company or any
                    of its Subsidiaries, the Executive shall serve in such
                    position as may be determined by the Board of Directors
                    ("Board") and shall perform all duties and accept all
                    responsibilities incident to such position or as may be
                    assigned to him by the Board, and shall at all times comply
                    with the policies and procedures adopted by the Company for
                    its employees.

               (ii) The Executive represents and covenants to the Company that
                    he is not subject or a party to any employment agreement,
                    non-competition agreement, nondisclosure agreement or any
                    similar agreement, covenant or restriction that would
                    prohibit the Executive from executing this Agreement and
                    performing his duties and responsibilities assigned by the
                    Company.
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          (c)  Extent of Service. So long as Executive is employed by the
               -----------------
               Company or any of its Subsidiaries, the Executive agrees to use
               his best efforts to carry out his duties and responsibilities
               under paragraph 1 (b) hereof and to devote his full professional
               time and attention thereto.

          (d)  Base Compensation. For all the services rendered by the Executive
               -----------------
               hereunder, the Company shall, commencing on the agreed upon start
               date of January 10, 2000, and continuing so long as Executive is
               employed by the Company or any of its Subsidiaries, pay the
               Executive an annual salary at the rate of $225,000 per year, plus
               any additional amounts, if any, as may be approved by a majority
               of the Board, less withholding required by law or agreed to by
               the Executive, and payable in installments at such times as is
               customary with the Company but in any event no less frequently
               than monthly. The Company agrees that the Executive's salary will
               be reviewed annually by the Board to determine if any adjustment
               is appropriate. For purposes of paragraph 1 (f) and Section 3
               herein, Executive's annual salary shall not be less than
               $225,000. So long as Executive is employed by the Company or any
               of its Subsidiaries, the Executive shall also be entitled to
               participate in such vacation pay and any other fringe benefit
               plans as may from time to time be adopted by a majority of the
               Board and as are made available generally to other senior
               executives of the Company.

          (e)  Incentive Compensation. In addition to the compensation set
               ----------------------
               forth in paragraph 1 (d) above, so long as the Executive is
               employed by the Company or its Subsidiaries the Executive shall
               be entitled to participate in a discretionary annual bonus plan
               providing for the payment to Executive of an annual bonus, in an
               amount to be determined by a majority of the Board or another
               officer of the Company as the Board determines. Executive shall
               be entitled to provide his input on the terms of his annual bonus
               plan before it is submitted to the Company's Board, but Executive
               acknowledges that such plan is discretionary in nature and is
               determined in the exclusive discretion of the Board or other
               officer so designated by the Board. The Company may adopt from
               time to time a bonus program, in which the Executive shall
               participate, the terms of which require the Company to achieve
               certain performance goals which are set in advance each year in
               the sole discretion of the Board.

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          (f)  Severance Pay. If at any time after the date hereof Executive
               -------------
               ceases to be employed by the Company and its Subsidiaries
               ("Termination") for death or disability or by the Company for any
               reason other than Cause, or by Executive for Good Reason (a
               "Covered Termination"), Executive (or, in the case of death,
               Executive's estate) shall, until the end of the Severance Pay
               Period (as defined below), be entitled to receive a salary at the
               same rate of pay as, and on the same schedule and terms as was
               customary for, the salary Executive received under paragraph 1
               (d) above immediately prior to the Termination, as well as
               (except in the case of Executive's death) comparable medical
               benefits to those provided by the Company to Executive
               immediately prior to the Termination (such salary and benefits
               collectively, the "Severance Pay"); provided that if at any time
               during the Severance Pay Period Executive obtains other
               employment, Executive's Severance Pay shall during the period of
               such employment be reduced (but not below zero) by the amount of
               salary and benefits Executive receives as compensation for such
               employment; (ii) all restricted stock theretofore granted to
               Executive shall vest immediately; and (iii) all stock options
               theretofore granted to Executive and scheduled to vest within 12
               months of the Covered Termination shall vest immediately. The
               payment of such Severance Pay shall in no way be construed as a
               continuation of Executive's employment after the Termination. The
               "Severance Pay Period" shall be equal to (i) if Executive is
               terminated by the Company for any reason other than Cause, the
               longer of (A) the period between the Covered Termination and the
               12-month anniversary of the start date of employment of
               Executive, and (B) the 6-month period commencing on the date of
               the Covered Termination, or (ii) if Executive's employment is
               terminated due to Good Reason, death or disability, the 6-month
               period commencing on the date of the Covered Termination. If
               Executive resigns other than for Good Reason or is terminated by
               the Company for Cause, the Company shall not be obligated to pay
               any Severance Pay or provide vesting of any restricted stock or
               stock options as provided in this paragraph.

          (g)  Nondisclosure and Nonuse of Confidential Information.
               ----------------------------------------------------

               (i)  Nondisclosure Obligation. Executive shall not disclose or
                    ------------------------
                    use at any time, either during his employment with the
                    Company or thereafter, any Confidential Information (as
                    defined below) of which Executive is or becomes aware,
                    whether or not such information is developed by him except
                    to the extent that such disclosure or use is directly
                    related to and required by Executive's performance of duties
                    assigned to Executive by the Company. Executive shall take
                    all appropriate steps to safeguard Confidential Information
                    and to protect it against disclosure, misuse, espionage,
                    loss and theft.

               (ii) Confidential Information. As used in this Agreement, the
                    ------------------------
                    term "Confidential Information" means information that is
                    not generally known to the public and that is used,
                    developed or obtained by the Company in connection with its
                    business, including but not limited to (i) products or
                    services, (ii) fees, costs and pricing structures, (iii)
                    designs,

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                    (iv) analysis, (v) drawings, photographs and reports, (vi)
                    computer software, including operating systems, applications
                    and program listings, (vii) flow charts, manuals and
                    documentation, (viii) data bases, (ix) accounting and
                    business methods, (x) inventions, devices, new developments,
                    methods and processes, whether patentable or unpatentable
                    and whether or not reduced to practice, (xi) customers and
                    clients and customer or client lists, (xii) copyrightable
                    works, (xiv) all technology and trade secrets, (xv) business
                    plans and financial models, and (xvi) all similar and
                    related information in whatever form. Confidential
                    Information shall not include any information that has been
                    published in a form generally available to the public prior
                    to the date Executive proposes to disclose or use such
                    information. Information shall not be deemed to have been
                    published merely because individual portions of the
                    information have been separately published, but only if all
                    material features constituting such information have been
                    published in combination.

          (h)  Cause. Cause means a finding by 2/3rds of the Board members then
               -----
               serving, after Executive has been given the opportunity for a
               formal hearing, of (A) Executive's theft or embezzlement, or
               attempted theft or embezzlement, of money or property of the
               Company, Executive's perpetration or attempted perpetration of
               fraud, or Executive's participation in a fraud or attempted
               fraud, on the Company, or Executive's unauthorized appropriation
               of, or attempt to misappropriate, any tangible or intangible
               assets or property of the Company, (B) any act or acts of
               disloyalty, misconduct or moral turpitude by Executive injurious
               to the interest, property, operations, business or reputation of
               the Company or Executives' conviction of a crime the commission
               of which results in injury to the Company, or (C) Executive's
               refusal or failure (other than by reason of disability) to carry
               out reasonable instructions by his superiors or the Board and in
               the case of subsection (C), the failure of Executive to cure the
               same within 10 business days, after receipt of written notice
               thereof from the Company.

          (i)  Good Reason. "Good Reason" means (A) a significant adverse change
               -----------
               by the Company in the nature or scope of the duties attached to
               Employee's positions as Executive Vice President and President,
               respectively, (B) the willful failure or refusal of Company to
               perform its material obligation under Section 1(d) or (e) of this
               Agreement, or (C) the reduction by the Company of its
               expenditures for the operation of the Company's Data Services
               business in an amount that is materially less than the
               expenditures set forth in the Company's fiscal year 2000 budget
               unless such reduction is part of a reduction applicable generally
               to the Company's other operating units, or (D) the Company
               requires the Executive to have his principal location of work
               changed to a location which is in excess of 50 miles from
               Washington, D.C. without Executive's prior written consent, and,
               in the case of subsections (A), (B) or (C), the failure of the
               Company to cure the same within 10 business days after receipt of
               written notice thereof from Executive.

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     2.   The Company's Ownership of Intellectual Property.
          ------------------------------------------------

          (a)  Acknowledgment of Company Ownership. In the event that Executive
               -----------------------------------
               as part of his activities on behalf of the Company generates,
               authors or contributes to any invention, design, new development,
               device, product, method or process (whether or not patentable or
               reduced to practice or constituting Confidential Information),
               any copyrightable work (whether or not constituting Confidential
               Information) or any other form of Confidential Information
               relating directly or indirectly to the Company's business as now
               or hereinafter conducted (collectively, "Intellectual Property"),
               Executive acknowledges that such Intellectual Property is the
               exclusive property of the Company and hereby assigns all right,
               title and interest in and to such Intellectual Property to the
               Company. Any Intellectual Property that is copyrightable work
               prepared in whole or in part by Executive will be deemed "a work
               made for hire" under Section 201(b) of the 1976 Copyright Act,
               and the Company shall own all of the rights comprised by the
               copyright therein. Executive shall promptly and fully disclose to
               the Company all Intellectual Property he generates, authors or
               contributes to the Company and shall cooperate with the Company
               to protect the Company's interests in and rights to such
               Intellectual property (including, without limitation, providing
               reasonable assistance in securing patent protection and copyright
               registrations and executing all documents as reasonably requested
               by the Company, whether such requests occur prior to or after
               Termination of Executive's employment with the Company).

          (b)  Executive Invention. Executive understands that paragraph 2 of
               -------------------
               this Agreement regarding the Company's ownership of Intellectual
               Property does not apply to any invention for which no equipment,
               supplies, facilities or trade secret information of the Company
               were used and which was developed entirely on Executive's own
               time, unless (i) the invention relates to the business of the
               Company or to the Company's actual or demonstrably anticipated
               research or development or (ii) the invention results from any
               work performed by Executive for the Company.

          (c)  Delivery of Materials upon Termination of Employment. As
               ----------------------------------------------------
               requested by the Company from time to time and upon the
               Termination of Executive's employment with the Company for any
               reason, Executive shall promptly deliver to the Company all
               copies and embodiments, in whatever form, of all Confidential
               Information and Intellectual Property in Executive's possession
               or within his control (including, but not limited to, written
               records, notes, photographs, manuals, notebooks, documentation,
               program listings, flow charts, magnetic media, disks, diskettes,
               tapes and all other materials containing any Confidential
               Information or Intellectual Property) irrespective of the
               location or form of such material and, if requested by the
               Company shall provide the Company with written confirmation that
               all such materials have been delivered to the Company.

     3.   Noncompetition and Nonsolicitation.
          ----------------------------------

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          (a)  Noncompetition. Executive acknowledges and agrees with the
               --------------
               Company that Executive's services to the Company are unique in
               nature and that the Company would be irreparably damaged if
               Executive were to provide similar services to any person or
               entity competing with the Company or engaged in a similar
               business. For and in consideration of the terms contained herein
               Executive covenants and agrees with the Company that during the
               Noncompetition Period (as defined below), Executive shall not,
               directly or indirectly, either for himself or for any other
               individual, corporation, partnership, joint venture or other
               entity, participate in any business division, group or franchise
               (or if there are no divisions, any business) where such division,
               group or franchise (or business, if applicable) engages or
               proposes to engage in any business conducted by the Company or
               proposed to be conducted pursuant to a Board resolution or
               Subsequent Business Plan (including, but not limited to, the sale
               or distribution of local switched dial tone telecommunication
               services) in any metropolitan statistical area ("MSA") in which
               the Company conducts such business or proposes to conduct such
               business pursuant to a Board resolution or Subsequent Business
               Plan. For purposes of this Agreement, the term "participate in"
               shall include, without limitation, having any direct or indirect
               interest in any corporation, partnership, joint venture or other
               entity, whether as a sole proprietor, owner, stockholder,
               partner, joint venturer, creditor or otherwise, or rendering any
               direct or indirect service or assistance to any individual,
               corporation, partnership, joint venture and other business entity
               (whether as a director, officer, manager, supervisor, employee,
               agent, consultant or otherwise), other than ownership of up to 2%
               of the outstanding stock of any class which is publicly traded.

          (b)  Nonsolicitation. During the Noncompetition Period, Executive
               ---------------
               shall not (i) induce or attempt to induce any employee of the
               Company to leave the employ of the Company, or in any way
               interfere with the relationship between the Company and any
               employee thereof, (ii) hire directly or through another entity
               any person who was an employee of the Company at any time during
               the Noncompetition Period, or (iii) induce or attempt to induce
               any customer, supplier, licensee or other business relation of
               the Company to cease doing business with the Company, or in any
               way interfere with the relationship between any such customer,
               supplier, licensee or relation and the Company (including,
               without limitation, making any negative statements or
               communications concerning the Company).

          (c)  Noncompetition Period. The "Noncompetition Period" shall commence
               ---------------------
               on the date hereof and continue (i) if Executive is terminated by
               the Company with or without Cause, until such date as shall be
               specified by the Company in writing within 14 calendar days after
               Termination, provided that such date shall not be later than the
               first anniversary of the Termination, or (ii) otherwise, until
               such date as shall be specified by the Company in writing within
               the 30 calendar days after Termination, provided that such date
               shall not be later than the 18-month anniversary of the
               Termination. After the end

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               of the Severance Pay Period (or if there is no Severance Pay, the
               date upon which the Company elects the duration of the
               Noncompetition Period), the Company shall until the end of the
               Noncompetition Period pay Executive his Noncompete Compensation
               (unless Executive breaches his obligations under this paragraph
               3, it being understood that in such case Executive shall continue
               to be bound by such obligations as if the Company were continuing
               to pay Noncompete Compensation). If there is no Severance Pay,
               the Company shall during the period from Termination until such
               time as the Company elects the duration of the Noncompetition
               Period (the "Interim Period"), pay Executive his Interim
               Compensation (unless Executive breaches his obligations under
               this paragraph 3, it being understood that in such case Executive
               shall continue to be bound by such obligations as if the Company
               were continuing to pay Interim Compensation). "Noncompete
               Compensation" shall consist of 50% of the salary that Executive
               received under paragraph 1 (d) above as compensation from the
               Company and its Subsidiaries immediately prior to termination
               (Executive's "Previous Salary") together with the continuation of
               the medical benefits that the Company provided to Executive
               immediately prior to Termination (Executive's "Previous
               Benefits"); provided that if at any time during the
               Noncompetition Period Executive obtains other employment (i) with
               comparable medical benefits to Executive's Previous Benefits,
               Executive's Noncompete Compensation shall during the period of
               such employment not include the continued provision of medical
               benefits, and (ii) with a salary exceeding 50% of Executive's
               Previous Salary, Executive's Noncompete Compensation shall during
               the period of such employment be reduced (but not below zero) by
               the amount of such excess. "Interim Compensation" shall consist
               of 100% of Executive's Previous Salary and Previous Benefits,
               provided that if at any time during the Interim Period Executive
               obtains other employment, Executive's Interim Compensation shall
               during the period of such employment be reduced (but not less
               than zero) by the amount of salary and benefits received as
               compensation for such other employment.

     4.   Notices. Any notice provided for in this Agreement must be in writing
          -------
          and must be either personally delivered, mailed by first class mail
          (postage prepaid and return receipt requested) or sent by reputable
          overnight courier service (charges prepaid) to the recipient at the
          address below indicated:

          To the Company: Focal Communications Corporation
                          200 N. LaSalle Street
                          Chicago, IL 60601
                          ATTN: Vice President, Human Resources

          with a copy to: Focal Communications Corporation
                          200 N. LaSalle Street
                          Chicago, IL 60601
                          ATTN: General Counsel

          To Executive:

     or to such other address or to the attention of such other person as the
     recipient party shall

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     have specified by prior written notice to the sending party. Any notice
     under this Agreement shall be deemed to have been given when personally
     delivered, one business day after being sent by reputable overnight courier
     service, or three business days after being deposited in the U.S. mail.

     5.   General Provisions.
          ------------------

          (a)  Severability. Whenever possible, each provision of this Agreement
               ------------
               shall be interpreted in such manner as to be effective and valid
               under applicable law, but if any provision of this Agreement is
               held to be invalid, illegal or unenforceable in any respect under
               any applicable law or rule in any jurisdiction, such invalidity,
               illegality or unenforceability shall not affect any other
               provision or any other jurisdiction as if such invalid, illegal
               or unenforceable provision had never been contained herein.

          (b)  Complete Agreement. This Agreement, those documents expressly
               ------------------
               referred to herein and other documents of even date herewith
               embody the complete agreement and understanding among the parties
               and supersede and preempt any prior understandings, agreements or
               representations by or among the parties, written or oral, which
               may have related to the subject matter hereof, in any way.

          (c)  Counterparts. This Agreement may be executed in separate
               ------------
               counterparts, none of which need contain the signature of more
               than one party hereto but each of which shall be deemed to be an
               original and all of which taken together shall constitute one and
               the same agreement.

          (d)  Successors and Assigns. Except as otherwise provided herein, this
               ----------------------
               Agreement shall bind the parties hereto and their respective
               successors and assigns and shall inure to the benefit of and be
               enforceable by the parties hereto and their respective successors
               and assigns.

          (e)  Choice of Law. All questions concerning the construction,
               -------------
               validity, enforcement and interpretation of this Agreement and
               the exhibits hereto shall be governed by the laws of the State of
               Illinois.

          (f)  Remedies. Each of the parties to this Agreement shall be entitled
               --------
               to enforce its rights under this Agreement specifically, to
               recover damages and cost (including reasonable attorney's fees)
               caused by any breach of any provision of this Agreement and to
               exercise all other rights existing in its favor. The parties
               hereto agree and acknowledge that money damages would not be an
               adequate remedy for any breach of the provisions of this
               Agreement and that any party may in its sole discretion apply to
               any court of law or equity of competent jurisdiction (without
               posting any bond or deposit) for specific performance and/or
               other injunctive relief in order to enforce or prevent any
               violations of the provisions of this Agreement.

          (g)  Amendment and Waiver. The provisions of this Agreement may be
               --------------------
               amended

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               and waived only with the prior written consent of the Company and
               Executive.

          (h)  Business Days. If any time period for giving notice or taking
               -------------
               action hereunder expires on a day which is a Saturday, Sunday or
               legal holiday in the State of Illinois, the time period will be
               automatically extended to the business day immediately following
               such Saturday, Sunday or holiday.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement on the
date first written above.

FOCAL COMMUNICATIONS CORPORATION

By: /s/ Robert C. Taylor, Jr.
   --------------------------

Its: President and Chief Executive Officer

EXECUTIVE:

/s/ Michael L. Mael
______________________________________

                                       9<PAGE>

                                                                     Exhibit 4.1

                            SUBSCRIPTION AGREEMENT

     SUBSCRIPTION AGREEMENT (this "Agreement") made as of the date set forth on
the signature page hereof between Endorex Corporation, a Delaware Corporation
(the "Company") and the undersigned (the "Subscriber").

                             W I T N E S S E T H:

     WHEREAS, the Company and the Subscribers are executing and delivering this
Agreement in connection with the proposed sale of securities of the Company (the
"Offering"). This Agreement is being executed and delivered in reliance upon the
exemption from securities registration afforded by Rule 506 under Regulation D
("Regulation D") as promulgated by the United States Securities and Exchange
Commission (the "SEC") under the Securities Act of 1933, as amended (the "Act");
and

     WHEREAS, the Company desires to sell to the Subscriber and the Subscriber
desires to purchase from the Company the number of Units set forth beside such
Subscriber's name on the signature page hereto. Each "Unit" shall consist of (i)
a number of shares of common stock of the Company (rounded to the nearest whole
share, with one-half (0.5) of one share, or greater fraction thereof, being
rounded upward), par value $.001 per share (the "Common Stock"), determined by
dividing one hundred thousand dollars ($100,000) by the lower of (a) the average
closing price of the Common Stock, as quoted on the American Stock Exchange, for
the five (5) consecutive trading days immediately preceding the date on which
the Company executes this Agreement (the "Pricing Date"), (b) the average
closing price of the Common Stock, as quoted on the American Stock Exchange, for
the fifteen (15) consecutive trading days immediately preceding the Pricing Date
or (c) $7.25 (the lower of such prices being referred to herein as the "Common
Stock Price"); provided, however, that the Company shall not be obligated to
execute this Agreement or sell the Units if the Common Stock Price, were this
Agreement to be executed by the Company, would be below $3.25 and (ii) a warrant
(collectively, the "Warrants"), substantially in the form attached hereto as
Exhibit A, to purchase a number of shares of Common Stock equal to twenty five
percent (25%) of the shares of Common Stock included in such Unit, such warrants
to be exercisable, in whole or in part, at any time prior to the fifth
anniversary of the date of issuance at an exercise price equal to one hundred
twenty five percent (125%) of the Common Stock Price (the Common Stock, the
Warrants, and the Common Stock issuable upon the exercise of the Warrants are
sometimes herein collectively referred to as the "Securities").

     NOW, THEREFORE, in consideration of the promises and the mutual
representations and covenants hereinafter set forth, the parties hereto do
hereby agree as follows:

                                      -1-

<PAGE>

I.   SUBSCRIPTION FOR UNITS, REPRESENTATIONS AND COVENANTS BY SUBSCRIBER
     -------------------------------------------------------------------

          1.1  Subject to the terms and conditions hereinafter set forth, the
Subscriber hereby subscribes for and agrees to purchase from the Company such
number of Units and the Company agrees to sell such Units to the Subscriber as
is set forth upon the signature page hereof at a price equal to $100,000 per
Unit (the "Purchase Price"). The Purchase Price is payable by personal or
business check or wire transfer of immediately available funds made payable to
"State Street Bank & Trust Co., "Escrow Agent," F/B/O Endorex Corporation"
contemporaneously with the execution and delivery of this Agreement by the
Subscriber. The certificates representing the Common Stock, and the Warrants,
subscribed for pursuant to this Agreement will be delivered by the Company
within ten (10) days following the Pricing Date as set forth in Article III
hereof. The Subscriber understands, however, that this purchase of Units is
contingent upon the Company receiving subscriptions for a number of Units which
would provide aggregate gross proceeds to the Company of at least $2,000,000
(the "Minimum Offering") prior to May 1, 2000 (the "Offering Termination Date").

          1.2  The Subscriber recognizes that the purchase of Units involves a
high degree of risk, as set forth in the "Risk Factors" section of the Company's
Prospectus dated January 5, 2000, contained in the Subscriber Package (defined
in Section 1.5 hereof).

          1.3  The Subscriber represents that the Subscriber is an "accredited
investor" as such term is defined in Rule 501 of Regulation D promulgated under
the Act, as indicated by the Subscriber's responses to the questions contained
in the Confidential Investor Questionnaire attached hereto as Exhibit B (the
"Investor Questionnaire"), and that the Subscriber is able to bear the economic
risk of an investment in the Units.

          1.4  The Subscriber hereby acknowledges and represents that (i) the
Subscriber has prior investment experience, including investment in securities
which are non-listed, unregistered and/or not traded on the Nasdaq National or
SmallCap Market, a national or regional stock exchange (including, without
limitation, the New York Stock Exchange or the American Stock Exchange), or the
Subscriber has employed the services of an investment advisor, attorney and/or
accountant to read all of the documents furnished or made available by the
Company to the Subscriber and to all other prospective investors in the Units
and to evaluate the merits and risks of such an investment on the Subscriber's
behalf; (ii) the Subscriber recognizes the highly speculative nature of this
investment; and (iii) the Subscriber is able to bear the economic risk which the
Subscriber hereby assumes.

          1.5  The Subscriber hereby acknowledges receipt and careful review of
this Agreement and all attachments to it (including, without limitation, the
Offering Summary, the Executive Summary, the Warrant, the Company's press
release dated March 1, 2000, and the Company's periodic reports on Form 10-QSB
and Form 10-KSB (and Forms 8-K, if any) filed since March 29, 1999 and prior to
March 3, 2000, the Company's Proxy Statement for its 1999 Meeting of
Shareholders and the Company's Prospectus dated January 5, 2000 (the "SEC

                                      -2-

<PAGE>

Documents" and collectively with this Agreement and the attachments to it, the
"Subscriber Package")); and hereby represents that the Subscriber has been
furnished by the Company during the course of this transaction with all
information regarding the Company which the Subscriber has requested or desired
to know, has been afforded the opportunity to ask questions of and receive
answers from duly authorized officers or other representatives of the Company
concerning the terms and conditions of the Offering, and has received any
additional information which the Subscriber has requested.

          1.6  (a)  To the extent necessary, the Subscriber has retained, at
his/her/its sole expense, and relied upon appropriate professional advice
regarding the investment, tax and legal merits and consequences of this
Agreement and its purchase of the Units hereunder. The Subscriber acknowledges
and agrees that Paramount Capital, Inc. (the "Finder") has not supplied any
information other than information furnished in writing to the Company by Finder
relating to Finder, that Finder has no responsibility for the accuracy or
completeness of the information, and that the Subscriber has not relied upon the
independent investigation or verification, if any, which may have been
undertaken by the Finder.

               (b)  The Subscriber represents that no Units were offered or sold
to it by means of any form of general solicitation or general advertising, and
in connection therewith the Subscriber did not: (A) receive or review any
advertisement, article, notice or other communication published in a newspaper
or magazine or similar media or broadcast over television or radio whether
closed circuit, or generally available; or (B) attend any seminar meeting or
industry investor conference whose attendees were invited by any general
solicitation or general advertising.

          1.7  The Subscriber hereby represents that the Subscriber, either by
reason of the Subscriber's business or financial experience or the business or
financial experience of the Subscriber's professional advisors (who are
unaffiliated with, and who are not compensated by, the Company or any affiliate
or selling agent of the Company, including Finder, directly or indirectly), has
the capacity to protect the Subscriber's own interests in connection with the
transaction contemplated hereby.

          1.8  The Subscriber hereby acknowledges that the offering of Units has
not been reviewed by the United States Securities and Exchange Commission or any
state regulatory authority, since the Offering is intended to be exempt from the
registration requirements of Section 5 of the Act pursuant to Regulation D
promulgated under the Act. The Subscriber shall not sell or otherwise transfer
the Securities comprising the Units unless such Security is registered under the
Act or unless an exemption from such registration is available.

          1.9  The Subscriber understands that the Securities comprising the
Units have not been registered under the Act by reason of Rule 506 under
Regulation D of the Act, a claimed exemption under the provisions of the Act,
which depends, in part, upon the Subscriber's investment intention. In this
connection, the Subscriber hereby represents that the Subscriber is purchasing
the Securities comprising the Units for the Subscriber's own account for
investment

                                      -3-

<PAGE>

and not with a view toward the resale or distribution to others. The Subscriber,
if an entity, was not formed for the purpose of purchasing the Securities.

          1.10 The Subscriber understands that although there currently is a
public market for the Common Stock, Rule 144 ("Rule 144") promulgated under the
Act requires, among other conditions, a one-year holding period prior to the
resale (in limited amounts and subject to other restrictions) of securities
acquired in a non-public offering without having to satisfy the registration
requirements under the Act, unless such resale shall otherwise be exempt from
such registration requirements. The Subscriber understands and hereby
acknowledges that the Company is under no obligation to register any of the
Units or any of the Common Stock (including the Common Stock issuable upon
exercise of the Warrants) comprising the Units under the Act or any state
securities or "blue sky" laws other than as set forth in Article V herein. The
Subscriber agrees to hold the Company and its directors, officers, employees,
controlling persons and agents (including Finder and its officers, directors,
employees, counsel, controlling persons and agents) and their respective heirs,
representatives, successors and assigns harmless and to indemnify them against
all liabilities, costs and expenses incurred by them as a result of, (i) any
misrepresentation made by the Subscriber contained in this Agreement (including
the Investor Questionnaire), (ii) any sale or distribution by the Subscriber in
violation of the Act or any applicable state securities or "blue sky" laws or
(iii) any untrue statement of a material fact made by the Subscriber and
contained herein.

          1.11 The Subscriber consents to the placement of a legend on any
certificate or other document evidencing the Common Stock that such shares of
Common Stock have not been registered under the Act or any state securities or
"blue sky" laws and setting forth or referring to the restrictions on
transferability and sale thereof contained in this Agreement. The Subscriber is
aware that the Company will make a notation in its appropriate records with
respect to the restrictions on the transferability of such Common Stock.

          1.12 The Subscriber understands that the Company will review this
Agreement and is hereby given authority by the Subscriber to call Subscriber's
bank or place of employment or otherwise review the financial standing of the
Subscriber; and it is further agreed that the Company reserves the unrestricted
right, without further documentation or agreement on the part of the Subscriber,
to reject or limit any subscription, to accept subscriptions for fractional
units and to close the Offering to the Subscriber at any time.

          1.13 The Subscriber hereby represents that the address of the
Subscriber furnished by Subscriber on the signature page hereof is the
Subscriber's principal residence if Subscriber is an individual or its principal
business address if it is a corporation or other entity.

          1.14 The Subscriber represents that the Subscriber has full power and
authority (corporate, statutory and otherwise) to execute and deliver this
Agreement and to purchase the Securities comprising the Units. This Agreement
constitutes the legal, valid and binding obligation of the Subscriber,
enforceable against the Subscriber in accordance with its terms.

                                      -4-

<PAGE>

          1.15 If the Subscriber is a corporation, partnership, limited
liability company, trust, employee benefit plan, individual retirement account,
Keogh Plan, or other entity (a) it is authorized and qualified to become an
investor in the Company and the person signing this Agreement on behalf of such
entity has been duly authorized by such entity to do so and (b) it is duly
organized, validly existing and in good standing under the laws of the
jurisdiction of its organization.

          1.16 The Subscriber acknowledges that if he or she is a Registered
Representative of an NASD member firm, he or she must give such firm the notice
required by the NASD Rules of Fair Practice, receipt of which must be
acknowledged by such firm on the Investor Questionnaire.

          1.17 The Subscriber represents that since the period from the date
that Subscriber was first contacted with respect to the potential purchase of
Securities, the Subscriber has not sold "short" or "shorted against the box" (as
those terms are generally understood) any equity security of the Company. The
Subscriber covenants and agrees that until the last date upon which Subscriber
holds any Securities or Registrable Securities, the Subscriber shall not,
directly or indirectly, through related parties, affiliates or otherwise, (i)
sell "short" or "short against the box" (as those terms are generally
understood) any equity security of the Company or (ii) otherwise engage in any
transaction, except for any transaction contemplated by this Agreement, that
involves hedging of the Subscriber's position in any equity security of the
Company.

          1.18 The Subscriber represents that he/she/it is not an Affiliate (as
defined in Section 5.1 below) of the Company or a director, officer, employee or
agent of any such Affiliate of the Company.

II   REPRESENTATIONS BY AND COVENANTS OF THE COMPANY
     -----------------------------------------------

     The Company hereby represents and warrants to the Subscriber that:

          2.1  Organization, Good Standing and Qualification. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware and has full corporate power and authority to conduct
its business as described in the Company's financial statements. The Company is
duly qualified to do business as a foreign corporation and is in good standing
in the State of Illinois and in each jurisdiction in which the failure to do so
would have a material adverse effect on the Company's business or financial
condition.

          2.2  Capitalization. As of December 31, 1999, the authorized capital
stock of the Company consisted of (i) 50,000,000 shares of common stock, par
value $0.001 per share, of which 10,755,653 shares were issued and outstanding,
and of which 2,209,914 shares were reserved for issuance under the Company's
stock incentive plans (for which options to purchase 1,571,502 shares were
outstanding) and 2,459,600 shares were reserved for issuance under the

                                      -5-

<PAGE>

Company's outstanding warrants, and (ii) 500,000 shares of preferred stock, par
value $.05 per share, of which 183,177 shares were issued and outstanding. The
terms, preferences and privileges of the outstanding shares of capital stock are
set forth in the Company's Certificate of Incorporation as amended to the date
hereof (the "Certificate"). Except as set forth in the Company's financial
statements and other SEC filings, there are no existing options, warrants,
calls, preemptive (or similar) rights, subscriptions or other rights,
agreements, arrangements or commitments of any character obligating the Company
to issue, transfer or sell, or cause to be issued, transferred or sold, any
shares of the capital stock of the Company or other equity interests in the
Company or any securities convertible into or exchangeable for such shares of
capital stock or other equity interests, and there are no outstanding
contractual obligations of the Company to repurchase, redeem or otherwise
acquire any shares of its capital stock or other equity interests. Except as set
forth in Company's financial statements and other filings filed with the SEC, no
holder of any capital stock or securities of the Company has any registration
rights.

          2.3  Authorization; Enforceability. The Company has all corporate
right, power and authority to enter into this Agreement and to consummate the
transactions contemplated hereby. All corporate action on the part of the
Company, its directors and stockholders necessary for the authorization,
execution, delivery and performance of this Agreement by the Company, the
authorization, sale, issuance and delivery of the Securities contemplated herein
and the performance of the Company's obligations hereunder has been taken. This
Agreement has been duly executed and delivered by the Company and constitutes a
legal, valid and binding obligation of the Company, enforceable against the
Company in accordance with its terms, subject to laws of general application
relating to bankruptcy, insolvency and the relief of debtors and rules of law
governing specific performance, injunctive relief or other equitable remedies,
and to limitations of public policy. Upon the issuance and delivery of the
Securities as contemplated by this Agreement, and upon compliance by the
Subscriber with the terms hereof, such Securities will be validly issued, fully
paid and nonassessable. The Common Stock issuable upon exercise of the Warrants,
when issued in accordance with the terms thereof for the consideration expressed
therein, will have been duly and validly issued, fully paid and nonassessable.
The issuance and sale of the Securities contemplated hereby will not give rise
to any preemptive rights or rights of first refusal on behalf of any person.

          2.4  No Conflict; Governmental and Other Consents.

          (i)  The execution and delivery by the Company of this Agreement and
the consummation of the transactions contemplated hereby will not result in the
violation of any law, statute, rule, regulation, order, writ, injunction,
judgment or decree of any court or governmental authority to or by which the
Company is bound, or of any provision of the Certificate of Incorporation or By-
Laws of the Company, and will not conflict with, or result in a breach or
violation of, any of the terms or provisions of, or constitute (with due notice
or lapse of time or both) a default under, any lease, loan agreement, mortgage,
security agreement, trust indenture or other agreement or instrument to which
the Company is a party or by which it is bound or to which any of its properties
or assets is subject, nor result in the creation or imposition of any lien upon
any of the properties or assets of the Company.

                                      -6-

<PAGE>

          (ii) No consent, approval or authorization of or designation,
declaration or filing with any governmental authority on the part of the Company
is required in connection with the valid execution, delivery and performance of
this Agreement, except such filings as may be required to be made with the SEC,
the National Association of Securities Dealers, Inc. ("NASD"), the American
Stock Exchange ("AMEX"), such filings as may be required under the Hart-Scott-
Rodino Antitrust Improvements Act of 1976, as amended ("HSR") and filings with
governmental authorities for purposes of effecting compliance with the
securities and blue sky laws in the states in which Units are offered and/or
sold, which compliance, if required to be effected by the Company, will be
effected in accordance with such laws. The Company has not received any
delisting notices, notice of violation or similar inquiry regarding its
eligibility for listing from AMEX.

          2.5  Licenses. Except as set forth in the Company's financial
statements and other SEC filings, the Company has sufficient licenses, permits
and other governmental authorizations currently required for the conduct of its
business or ownership of properties and is in all material respects complying
therewith.

          2.6  Litigation. Except as set forth in the Company's financial
statements and other filings filed with the SEC, to the best knowledge of the
Company after due inquiry, there is no pending or threatened legal or
governmental proceedings against the Company which could materially adversely
affect the business, property, financial condition or operations of the Company.

          2.7  Accuracy of Reports. All material reports required to be filed by
the Company within the two years prior to the date of this Agreement under the
Securities Exchange Act of 1934, as amended (the "Exchange Act"), have been duly
filed with the Commission, complied at the time of filing in all material
respects with the requirements of their respective forms and, except to the
extent updated or superseded by any subsequently filed report, to the best of
the Company's knowledge, were complete and correct in all material respects as
of the dates at which the information was furnished, and contained (as of such
dates) no untrue statement of a material fact nor omitted to state any material
fact necessary in order to make the statements contained therein, in light of
the circumstances under which they were made, not misleading.

          2.8  Offering Summary; Disclosure. No information set forth in the
Offering Summary or in any exhibit to the Offering Summary contains, as of the
respective date thereof, any untrue statement of a material fact or omits to
state a material fact necessary in order to make the statements contained
therein, in light of the circumstances under which they were made, not
misleading.

          2.9  Investment Company. The Company is not an "investment company"
within the meaning of such term under the Investment Company Act of 1940, as
amended, and the rules and regulations of the Commission thereunder.

                                      -7-

<PAGE>

          2.10 Changes. Since September 30, 1999, there has not been (a) any
incurrence by the Company of any material liability, absolute or contingent, or
(b) any event or condition of any character that has materially and adversely
affected or might materially and adversely affect the business, properties,
prospects or financial condition of the Company (as such business is presently
conducted and as it is proposed to be conducted), except as has been disclosed
to Subscriber, including, without limitation, any disclosure made pursuant to
the Subscriber Package being furnished to the Subscriber herewith. There is no
material liability or contingency of the Company that is not disclosed in the
Subscriber Package.

          2.11 Patents and Trademarks. To its knowledge, except as disclosed in
the SEC Documents, the Company owns or possesses the right to use to all
patents, trademarks, service marks, tradenames, copyrights, trade secrets,
licenses, information and proprietary rights and processes necessary for its
business as now conducted and as proposed to be conducted, without infringement
of any rights of a third party. Except as is disclosed in the SEC Documents, the
Company has not received any communications alleging that the Company has
violated or, by conducting its business as proposed, would violate any of the
patents, trademarks, service marks, tradenames, copyrights, trade secrets or
other proprietary rights or processes of any other person or entity, which
violation would have a material adverse effect on the Company. Except as
disclosed in the SEC Documents, the Company has not granted (nor has the Company
licensed from a third party) any material rights to or licenses to its patents,
trademarks, service marks, tradenames, copyrights, trade secrets or other
proprietary rights or processes.

          2.12 Use of Proceeds. The Company currently intends that the net
proceeds of the Offering will be used by the Company for its research and
development activities, including preclinical and clinical studies, and general
corporate purposes. The Company may also use a portion of the net proceeds for
the acquisition of businesses, products and technologies.

III. TERMS OF SUBSCRIPTION
     ---------------------

          3.1  The Company shall sell to the Subscribers a number of Units which
would provide aggregate gross proceeds to the Company of at least $2,000,000
(the "Minimum Offering Amount") but in no event shall the Company sell to
Subscribers a number of Units comprised of more than 1,500,000 shares of Common
Stock (excluding the shares of Common Stock underlying the Warrants) (the
"Maximum Offering"), at a purchase price of $100,000 per Unit (the "Purchase
Price"). The Purchase Price is payable on the date of Subscriber's execution
hereof by personal or business check or wire transfer of immediately available
funds made payable to "State Street Bank & Trust Co., N.A., "Escrow Agent,"
F/B/O Endorex Corp." The Company may execute this Agreement at any time after
its receipt of the Minimum Offering Amount and prior to the Offering Termination
Date (the date of such execution being the "Pricing Date"). The Company shall
notify each Subscriber by telephone and/or facsimile that the Company has
executed this Agreement on the date of such execution. The Company shall deliver
the shares of Common Stock and the Warrants being subscribed for hereunder
directly to the Subscriber's account maintained by the Finder or, if no such
account exists, to the residential

                                      -8-

<PAGE>

or business address indicated on the signature page hereto, on a date specified
by the Company and the Finder (the "Closing Date"), provided, however, that the
Closing Date shall be no later than ten (10) days after the Pricing Date.

          3.2  Pending the sale of the Units, all funds paid hereunder shall be
held in escrow with the Escrow Agent, having a branch at 61 Broadway, New York,
New York. If the Company shall not have obtained subscriptions (including this
subscription) for purchases of the Minimum Offering on or before the Offering
Termination Date, then this subscription shall be void and all funds paid
hereunder by the Subscriber shall be promptly returned to the Subscriber, with
interest, if any; provided, however, that the Subscriber hereby authorizes and
directs the Company to return any funds for unaccepted subscriptions to the same
account from which the funds were drawn.

IV.  CONDITIONS TO OBLIGATIONS OF THE SUBSCRIBERS
     --------------------------------------------

          4.1  The Subscribers' obligation to purchase the Units at the Closing
is subject to the fulfillment on or prior to the Closing of the following
conditions, which conditions may be waived at the option of each Subscriber to
the extent permitted by law:

               (a)  Representations and Warranties Correct. The representations
and warranties made by the Company in Article II hereof shall be true and
correct in all material respects when made, and shall be true and correct in all
material respects on each Closing with the same force and effect as if they had
been made on and as of said date.

               (b)  Covenants. All covenants, agreements and conditions
contained in this Agreement to be performed by the Company on or prior to such
purchase shall have been performed or complied with in all material respects.

               (c)  Listing. The Company shall have filed an Application for
Listing of Additional Shares with the American Stock Exchange.

               (d)  No Legal Order Pending. There shall not then be in effect
any legal or other order enjoining or restraining the transactions contemplated
by this Agreement.

               (e)  No Law Prohibiting or Restricting Such Sale. There shall not
be in effect any law, rule or regulation prohibiting or restricting such sale or
requiring any consent or approval of any person which shall not have been
obtained to issue the Securities (except as otherwise provided in this
Agreement).

               (f)  Minimum Subscriptions. The Company shall have received
binding subscriptions for Units with an aggregate purchase price of at least
$2,000,000.

                                      -9-

<PAGE>

               (g)  Legal Opinion. At the Closing, counsel to the Company shall
have delivered to the Subscribers a legal opinion reasonably satisfactory to the
Finder relating to certain matters with respect to the Offering.

V.   REGISTRATION RIGHTS
     -------------------

          5.1  As used in this Agreement, the following terms shall have the
following meanings:

               (a)  "Affiliate" shall mean, with respect to any Person (as
defined below), any other Person controlling, controlled by or under direct or
indirect common control with such Person (for the purposes of this definition
"control," when used with respect to any specified Person, shall mean the power
to direct the management and policies of such person, directly or indirectly,
whether through ownership of voting securities, by contract or otherwise; and
the terms "controlling" and "controlled" shall have meanings correlative to the
foregoing).

               (b)  "Business Day" shall mean a day Monday through Friday on
which banks are generally open for business in New York.

               (c)  "Holders" shall mean the Subscribers and any person holding
Registrable Securities (including, without limitation, the shares of Common
Stock issuable upon exercise of the warrants to be granted to the Finder and/or
its designees pursuant to the Finders Agreement between the Company and the
Finder dated February 29, 2000 (such agreement being referred to herein as the
"Finders Agreement" and such warrants being referred to herein as the "Paramount
Warrants")) or any person to whom the rights under Article V have been
transferred in accordance with Section 5.9 hereof.

               (d)  "Person" shall mean any person, individual, corporation,
limited liability company, partnership, trust or other nongovernmental entity or
any governmental agency, court, authority or other body (whether foreign,
federal, state, local or otherwise).

               (e)  The terms "register," "registered" and "registration" refer
to the registration effected by preparing and filing a registration statement in
compliance with the Act, and the declaration or ordering of the effectiveness of
such registration statement.

               (f)  "Registrable Securities" shall mean (i) the shares of Common
Stock included in the Units; (ii) the shares of Common Stock issuable upon
exercise of the Warrants (the "Warrant Shares"); (iii) the shares of Common
Stock issuable upon exercise of the Paramount Warrants; (iv) any shares of
Common Stock issued as (or issuable upon the conversion of any warrant, right or
other security which is issued as) a dividend or other distribution with respect
to or in replacement of the Common Stock; provided, however, that securities
shall only be treated as Registrable Securities if and only for so long as they
(A) have not been disposed of pursuant to a registration statement declared
effective by the Commission, (B) have not been sold in a transaction exempt from
the registration and prospectus delivery

                                     -10-

<PAGE>

requirements of the Act so that all transfer restrictions and restrictive
legends with respect thereto are removed upon the consummation of such sale or
(C) are held by a Holder or a permitted transferee pursuant to Section 5.9.

               (g)  "Registration Expenses" shall mean all expenses incurred by
the Company in complying with Section 5.2 hereof, including, without limitation,
all registration, qualification and filing fees, printing expenses, fees and
expenses of counsel for the Company, blue sky fees and expenses and the expense
of any special audits incident to or required by any such registration (but
excluding the fees of legal counsel for any Holder).

               (h)  "Registration Statement" shall have the meaning ascribed to
such term in Section 5.2.

               (i)  "Registration Period" shall have the meaning ascribed to
such term in Section 5.4.

               (j)  "Selling Expenses" shall mean all underwriting discounts and
selling commissions applicable to the sale of Registrable Securities and all
fees and expenses of legal counsel for any Holder.

          5.2  No later than thirty (30) days after the Closing Date (the
"Filing Date"), the Company shall file a "shelf" registration statement on the
appropriate form (the "Registration Statement") with the Commission and use its
best efforts to effect the registration, qualifications or compliances
(including, without limitation, the execution of any required undertaking to
file post-effective amendments, appropriate qualifications or exemptions under
applicable blue sky or other state securities laws and appropriate compliance
with applicable securities laws, requirements or regulations) of the Registrable
Securities prior to the date which is 75 days after the Closing Date.
Notwithstanding the foregoing, the Company shall not be obligated to enter into
any underwriting agreement for the sale of any of the Registrable Securities.

          5.3  All Registration Expenses incurred in connection with any
registration, qualification, exemption or compliance pursuant to Section 5.2
shall be borne by the Company. All Selling Expenses relating to the sale of
securities registered by or on behalf of Holders shall be borne by such Holders
pro rata on the basis of the number of securities so registered.

          5.4  In the case of the registration, qualification, exemption or
compliance effected by the Company pursuant to this Agreement, the Company
shall, upon reasonable request, inform each Holder as to the status of such
registration, qualification, exemption and compliance. At its expense the
Company shall:

               (a)  use its best efforts to keep such registration, and any
qualification, exemption or compliance under state securities laws which the
Company determines to obtain, continuously effective until the Holders have
completed the distribution described in the registration statement relating
thereto. The period of time during which the Company is required hereunder to
keep the Registration Statement effective is referred to herein as "the
Registration

                                     -11-

<PAGE>

Period." Notwithstanding the foregoing, at the Company's election, the Company
may cease to keep such registration, qualification, exemption or compliance
effective with respect to any Registrable Securities, and the registration
rights of a Holder shall expire, at such time as they are no longer, by reason
of Rule 144 promulgated under the Act (or other exemption from registration
acceptable to the Company) required to register for the sale thereof; and

               (b)  advise the Holders:

                    (i)  when the Registration Statement or any amendment
thereto has been filed with the Commission and when the Registration Statement
or any post-effective amendment thereto has become effective;

                    (ii) of any request by the Commission for amendments or
supplements to the Registration Statement or the prospectus included therein or
for additional information;

                    (iii) of the issuance by the Commission of any stop order
suspending the effectiveness of the Registration Statement or the initiation of
any proceedings for such purpose;

                    (iv) of the receipt by the Company of any notification with
respect to the suspension of the qualification of the Registrable Securities
included therein for sale in any jurisdiction or the initiation or threatening
of any proceeding for such purpose; and

                    (v)  of the happening of any event that requires the making
of any changes in the Registration Statement or the prospectus so that, as of
such date, the statements therein are not misleading and do not omit to state a
material fact required to be stated therein or necessary to make the statements
therein (in the case of the prospectus, in the light of the circumstances under
which they were made) not misleading;

               (c)  make every reasonable effort to obtain the withdrawal of any
order suspending the effectiveness of any Registration Statement at the earliest
possible time;

               (d)  furnish to each Holder upon request, without charge, at
least one copy of such Registration Statement and any post-effective amendment
thereto, including financial statements and schedules, and, if the Holder so
requests in writing, all exhibits (including those incorporated by reference) in
the form filed with the Commission;

               (e)  during the Registration Period, deliver to each Holder,
without charge, as many copies of the prospectus included in such Registration
Statement and any amendment or supplement thereto as such Holder may reasonably
request; and the Company consents to the use, consistent with the provisions
hereof, of the prospectus or any amendment or supplement thereto by each of the
selling Holders of Registrable Securities in connection with the offering and
sale of the Registrable Securities covered by the prospectus or any amendment or
supplement thereto. In addition, upon the reasonable request of the Holder and
subject in all

                                     -12-

<PAGE>

cases to confidentiality protections reasonably acceptable to the Company, the
Company will meet with a Holder or a representative thereof at the Company's
headquarters to discuss all information relevant for disclosure in the
Registration Statement covering the Registrable Securities, and will otherwise
cooperate with any Holder conducting an investigation for the purpose of
reducing or eliminating such Holder's exposure to liability under the Act,
including the reasonable production of information at the Company's
headquarters;

               (f)  prior to any public offering of Registrable Securities
pursuant to any Registration Statement, register or qualify or obtain an
exemption for offer and sale under the securities or blue sky laws of such
jurisdictions as any such Holders reasonably request in writing, provided that
the Company shall not for any such purpose be required to qualify generally to
transact business as a foreign corporation in any jurisdiction where it is not
so qualified or to consent to general service of process in any such
jurisdiction, and do any and all other acts or things reasonably necessary or
advisable to enable the offer and sale in such jurisdictions of the Registrable
Securities covered by such Registration Statement;

               (g)  cooperate with the Holders to facilitate the timely
preparation and delivery of certificates representing Registrable Securities to
be sold pursuant to any Registration Statement free of any restrictive legends
to the extent not required at such time and in such denominations and registered
in such names as Holders may request at least three (3) business days prior to
sales of Registrable Securities pursuant to such Registration Statement;

               (h)  upon the occurrence of any event contemplated by Section
5.4(b)(v) above, the Company shall promptly prepare a post-effective amendment
to the Registration Statement or a supplement to the related prospectus, or file
any other required document so that, as thereafter delivered to purchasers of
the Registrable Securities included therein, the prospectus will not include any
untrue statement of a material fact or omit to state any material fact necessary
to make the statements therein, in the light of the circumstances under which
they were made, not misleading.

          5.5  The Holders shall have no right to take any action to restrain,
enjoin or otherwise delay any registration pursuant to Section 5.2 hereof as a
result of any controversy that may arise with respect to the interpretation or
implementation of this Agreement.

          5.6  (a)  To the extent permitted by law, the Company shall indemnify
each Holder and each person controlling such Holder within the meaning of
Section 15 of the Act, with respect to which any registration, qualification or
compliance has been effected pursuant to this Agreement, against all claims,
losses, damages and liabilities (or action in respect thereof), including any of
the foregoing incurred in settlement of any litigation, commenced or threatened
(subject to Section 5.6(c) below), arising out of or based on any untrue
statement (or alleged untrue statement) of a material fact contained in any
registration statement, prospectus or offering circular, or any amendment or
supplement thereof, incident to any such registration, qualification or
compliance, or based on any omission (or alleged omission) to state therein a
material fact required to be stated therein or necessary to make the statements
therein not misleading, in light of the circumstances in which they were made,
and will reimburse each

                                     -13-

<PAGE>

Holder and each person controlling such Holder, for reasonable legal and other
expenses reasonably incurred in connection with investigating or defending any
such claim, loss, damage, liability or action as incurred; provided that the
Company will not be liable in any such case to the extent that any untrue
statement or omission or allegation thereof is made in reliance upon and in
conformity with written information furnished to the Company by or on behalf of
such Holder and stated to be specifically for use in preparation of such
registration statement, prospectus or offering circular; and, provided further,
that the Company will not be liable in any such case where the claim, loss,
damage or liability arises out of or is related to the failure of the Holder to
comply with the covenants and agreements contained in this Agreement respecting
sales of Registrable Securities, or the failure of the Finder to comply with the
covenants and agreements contained in the Finders Agreement (as defined in
Section 5.1(c) hereof), and except that the foregoing indemnity agreement is
subject to the condition that, insofar as it relates to any such untrue
statement or alleged untrue statement or omission or alleged omission made in
the preliminary prospectus but eliminated or remedied in the amended prospectus
on file with the Commission at the time the registration statement becomes
effective or in the amended prospectus filed with the Commission pursuant to
Rule 424(b) or in the prospectus subject to completion and term sheet under Rule
434 of the Act, which together meet the requirements of Section 10(a) of the Act
(the "Final Prospectus"), such indemnity agreement shall not inure to the
benefit of any such Holder or any such controlling person, if a copy of the
Final Prospectus furnished by the Company to the Holder for delivery was not
furnished to the person or entity asserting the loss, liability, claim or damage
at or prior to the time such furnishing is required by the Act and the Final
Prospectus would have cured the defect giving rise to such loss, liability,
claim or damage.

               (b)  Each Holder will severally, if Registrable Securities held
by such Holder are included in the securities as to which such registration,
qualification or compliance is being effected, indemnify the Company, each of
its directors and officers, each underwriter of the Registrable Securities and
each person who controls the Company within the meaning of Section 15 of the
Act, against all claims, losses, damages and liabilities (or actions in respect
thereof), including any of the foregoing incurred in settlement of any
litigation, commenced or threatened (subject to Section 5.6(c) below), arising
out of or based on any untrue statement (or alleged untrue statement) of a
material fact contained in any registration statement, prospectus or offering
circular, or any amendment or supplement thereof, incident to any such
registration, qualification or compliance, or based on any omission (or alleged
omission) to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, in light of the
circumstances in which they were made, and will reimburse the Company, such
directors and officers, each underwriter of the Registrable Securities and each
person controlling the Company for reasonable legal and any other expenses
reasonably incurred in connection with investigating or defending any such
claim, loss, damage, liability or action as incurred, in each case to the
extent, but only to the extent, that such untrue statement or omission or
allegation thereof is made in reliance upon and in conformity with written
information furnished to the Company by or on behalf of the Holder and stated to
be specifically for use in preparation of such registration statement,
prospectus or offering circular; provided that the indemnity shall not apply to
the extent that such claim, loss, damage or liability results from the fact that
a current copy of the prospectus was not made available to the Holder and such
current

                                     -14-

<PAGE>

copy of the prospectus would have cured the defect giving rise to such loss,
claim, damage or liability. Notwithstanding the foregoing, in no event shall a
Holder be liable for any such claims, losses, damages or liabilities in excess
of the proceeds received by such Holder in the offering, except in the event of
fraud by such Holder.

               (c)  Each party entitled to indemnification under this Section
5.6 (the "Indemnified Party") shall give notice to the party required to provide
indemnification (the "Indemnifying Party") promptly after such Indemnified Party
has actual knowledge of any claim as to which indemnity may be sought, and shall
permit the Indemnifying Party to assume the defense of any such claim or any
litigation resulting therefrom, provided that counsel for the Indemnifying
Party, who shall conduct the defense of such claim or litigation, shall be
approved by the Indemnified Party (whose approval shall not unreasonably be
withheld), and the Indemnified Party may participate in such defense at such
Indemnified Party's expense, and provided further that the failure of any
Indemnified Party to give notice as provided herein shall not relieve the
Indemnifying Party of its obligations under this Agreement, unless such failure
is materially prejudicial to the Indemnifying Party in defending such claim or
litigation. An Indemnifying Party shall not be liable for any settlement of an
action or claim effected without its written consent (which consent will not be
unreasonably withheld).

               (d)  If the indemnification provided for in this Section 5.6 is
held by a court of competent jurisdiction to be unavailable to an Indemnified
Party with respect to any loss, liability, claim, damage or expense referred to
therein, then the Indemnifying Party, in lieu of indemnifying such Indemnified
Party thereunder, shall contribute to the amount paid or payable by such
Indemnified Party as a result of such loss, liability, claim, damage or expense
in such proportion as is appropriate to reflect the relative fault of the
Indemnifying Party on the one hand and of the Indemnified Party on the other in
connection with the statements or omissions which resulted in such loss,
liability, claim, damage or expense as well as any other relevant equitable
considerations. The relative fault of the Indemnifying Party and of the
Indemnified Party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the
omission to state a material fact relates to information supplied by the
Indemnifying Party or by the Indemnified Party and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
statement or omission.

          5.7  (a)  Each Holder agrees that, upon receipt of any notice from the
Company of the happening of any event requiring the preparation of a supplement
or amendment to a prospectus relating to Registrable Securities so that, as
thereafter delivered to the Holders, such prospectus shall not contain an untrue
statement of a material fact or omit to state any material fact required to be
stated therein or necessary to make the statements therein not misleading, each
Holder will forthwith discontinue disposition of Registrable Securities pursuant
to the registration statement contemplated by Section 5.2 until its receipt of
copies of the supplemented or amended prospectus from the Company and, if so
directed by the Company, each Holder shall deliver to the Company all copies,
other than permanent file copies then in such Holder's possession, of the
prospectus covering such Registrable Securities current at the time of receipt
of such notice.

                                     -15-

<PAGE>

               (b)  Each Holder shall suspend, upon request of the Company, any
disposition of Registrable Securities pursuant to the Registration Statement and
prospectus contemplated by Section 5.2 during (i) any period not to exceed two
30-day periods within any one 12-month period the Company requires in connection
with a primary underwritten offering of equity securities and (ii) any period,
not to exceed one 45-day period per circumstance or development, when the
Company determines in good faith that offers and sales pursuant thereto should
not be made by reason of the presence of material undisclosed circumstances or
developments with respect to which the disclosure that would be required in such
a prospectus is premature, would have an adverse effect on the Company or is
otherwise inadvisable.

               (c)  As a condition to the inclusion of its Registrable
Securities, each Holder shall furnish to the Company such information regarding
such Holder and the distribution proposed by such Holder as the Company may
request in writing or as shall be required in connection with any registration,
qualification or compliance referred to in this Article V.

               (d)  Each Holder hereby covenants with the Company (i) not to
make any sale of the Registrable Securities without effectively causing the
prospectus delivery requirements under the Act to be satisfied, and (ii) if such
Registrable Securities are to be sold by any method or in any transaction other
than on a national securities exchange, Nasdaq National Market, Nasdaq SmallCap
Market or in the over-the-counter market, in privately negotiated transactions,
or in a combination of such methods, to notify the Company at least five (5)
business days prior to the date on which the Holder first offers to sell any
such Registrable Securities.

               (e)  Each Holder acknowledges and agrees that the Registrable
Securities sold pursuant to the Registration Statement described in this Section
are not transferable on the books of the Company unless the stock certificate
submitted to the transfer agent evidencing such Registrable Securities is
accompanied by a certificate reasonably satisfactory to the Company to the
effect that (i) the Registrable Securities have been sold in accordance with
such Registration Statement and (ii) the requirement of delivering a current
prospectus has been satisfied.

               (f)  Each Holder agrees not to take any action with respect to
any distribution deemed to be made pursuant to such registration statement which
would constitute a violation of Regulation M under the Exchange Act or any other
applicable rule, regulation or law.

               (g)  At the end of the period during which the Company is
obligated to keep the Registration Statement current and effective as described
above, the Holders of Registrable Securities included in the Registration
Statement shall discontinue sales of shares pursuant to such Registration
Statement upon receipt of notice from the Company of its intention to remove
from registration the shares covered by such Registration Statement which remain
unsold, and such Holders shall notify the Company of the number of shares
registered which remain unsold immediately upon receipt of such notice from the
Company.

                                     -16-

<PAGE>

          5.8  With a view to making available to the Holders the benefits of
certain rules and regulations of the Commission which at any time permit the
sale of the Registrable Securities to the public without registration, the
Company shall use its reasonable best efforts to:

               (a)  make and keep public information available, as those terms
are understood and defined in Rule 144 under the Act, at all times;

               (b)  file with the Commission in a timely manner all reports and
other documents required of the Company under the Exchange Act; and

               (c)  so long as a Holder owns any unregistered Registrable
Securities, furnish to such Holder, upon any reasonable request, a written
statement by the Company as to its compliance with Rule 144 under the Act, and
of the Exchange Act, a copy of the most recent annual or quarterly report of the
Company, and such other reports and documents of the Company as such Holder may
reasonably request in availing itself of any rule or regulation of the
Commission allowing a Holder to sell any such securities without registration.

          5.9  The rights to cause the Company to register Registrable
Securities granted to the Holders by the Company under Section 5.1 may be
assigned in full by a Holder in connection with a transfer by such Holder of its
Registrable Securities, provided, however, that (i) such transfer may otherwise
be effected in accordance with applicable securities laws; (ii) such Holder
gives prior written notice to the Company; and (iii) such transferee agrees to
comply with the terms and provisions of this Agreement, and such transfer is
otherwise in compliance with this Agreement. Except as specifically permitted by
this Section 5.9, the rights of a Holder with respect to Registrable Securities
as set out herein shall not be transferable to any other Person, and any
attempted transfer shall cause all rights of such Holder therein to be
forfeited.

          5.10 With the written consent of the Company and the Holders holding
at least a majority of the Registrable Securities that are then outstanding, any
provision of this Article V may be waived (either generally or in a particular
instance, either retroactively or prospectively and either for a specified
period of time or indefinitely) or amended. Upon the effectuation of each such
waiver or amendment, the Company shall promptly give written notice thereof to
the Holders, if any, who have not previously received notice thereof or
consented thereto in writing.

          5.11 Except to the extent any delay is due to the failure of a
Subscriber or the Finder to reasonably cooperate in providing to the Company
such information as shall be reasonably requested by the Company for use in the
Registration Statement, in the event that the Registration Statement is not
filed by the date that is 30 days following the Closing Date, the Company shall,
for no additional consideration, pay to each Subscriber as liquidated damages
and not as a penalty an amount in cash equal to one percent (1%) of the amount
invested by such Subscriber for each 30 day period in which the Registration
Statement remains unfiled; provided, however, that in no event shall the amount
of liquidated damages payable by the Company to any

                                     -17-

<PAGE>

Subscriber pursuant to this Section 5.11 exceed twelve percent (12%) of the
amount invested by such Subscriber.

VI   MISCELLANEOUS
     -------------

          6.1  Any notice or other communication given hereunder shall be deemed
sufficient if in writing and sent by registered or certified mail, return
receipt requested, or delivered by hand against written receipt therefore,
addressed to Endorex Corporation, 28101 Ballard Drive, Suite F, Lake Forest, IL
60045 Attn: Chief Financial Officer, and to the Subscriber at the Subscriber's
address indicated on the signature page of this Agreement. Notices shall be
deemed to have been given or delivered on the date of mailing, except notices of
change of address, which shall be deemed to have been given or delivered when
received.

          6.2  Except as provided in Section 5.10 above, this Agreement shall
not be changed, modified or amended except by a writing signed by the parties to
be charged, and this Agreement may not be discharged except by performance in
accordance with its terms or by a writing signed by the party to be charged.

          6.3  Subject to the provisions of Section 5.9 and 6.13, this Agreement
shall be binding upon and inure to the benefit of the parties hereto and to
their respective heirs, legal representatives, successors and assigns. This
Agreement sets forth the entire agreement and understanding between the parties
as to the subject matter hereof and merges and supersedes all prior discussions,
agreements and understandings of any and every nature among them.

          6.4  Upon the execution and delivery of this Agreement by the
Subscriber, this Agreement shall become a binding obligation of the Subscriber
with respect to the purchase of Units as herein provided; subject, however, to
the right hereby reserved to the Company to enter into the same agreements with
other subscribers and to add and/or delete other persons as subscribers.

          6.5  NOTWITHSTANDING THE PLACE WHERE THIS AGREEMENT MAY BE EXECUTED BY
ANY OF THE PARTIES HERETO, THE PARTIES EXPRESSLY AGREE THAT ALL THE TERMS AND
PROVISIONS HEREOF SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS
OF THE STATE OF NEW YORK WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. IN
THE EVENT THAT A JUDICIAL PROCEEDING IS NECESSARY, THE EXCLUSIVE FORUMS FOR
RESOLVING DISPUTES ARISING OUT OF OR RELATING TO THIS AGREEMENT ARE EITHER THE
SUPREME COURT OF THE STATE OF NEW YORK IN AND FOR THE COUNTY OF NEW YORK OR THE
FEDERAL COURTS FOR SUCH STATE AND COUNTY, AND ALL RELATED APPELLATE COURTS, THE
PARTIES HEREBY IRREVOCABLY CONSENT TO THE JURISDICTION OF SUCH COURTS AND AGREE
TO SAID VENUE.

                                     -18-

<PAGE>

          6.6  It is agreed that a waiver by either party of a breach of any
provision of this Agreement shall not operate, or be construed, as a waiver of
any subsequent breach by that same party.

          6.7  The parties agree to execute and deliver all such further
documents, agreements and instruments and take such other and further action as
may be necessary or appropriate to carry out the purposes and intent of this
Agreement.

          6.8  This Agreement may be executed in two or more counterparts each
of which shall be deemed an original, but all of which shall together constitute
one and the same instrument.

          6.9  (a)  The Subscribers severally agree not to issue any public
statement with respect to the Subscribers' investment or proposed investment in
the Company or the terms of any agreement or covenant between them and the
Company without the Company's prior written consent, except such disclosures as
may be required under applicable law or under any applicable order, rule or
regulation.

               (b)  The Company agrees not to disclose the names, addresses or
any other information about the Subscribers, except as required by law;
provided, that the Company may use the name (but not the address) of the
Subscriber in the Registration Statement.

          6.10 (a)  Each Subscriber severally represents and warrants that it
has not engaged, consented to nor authorized any broker, finder or intermediary
to act on its behalf, directly or indirectly, as a broker, finder or
intermediary in connection with the transactions contemplated by this Agreement.
Each Subscriber hereby severally agrees to indemnify and hold harmless the
Company from and against all fees, commissions or other payments owing to any
such person or firm acting on behalf of such Subscriber hereunder.

               (b)  The Company has not engaged, consented to or authorized any
broker, finder or intermediary to act on its behalf, directly or indirectly, as
a broker, finder or intermediary in connection with the transactions
contemplated by this Agreement, except for Paramount Capital, Inc.

          6.11 Nothing in this Agreement shall create or be deemed to create any
rights in any person or entity not a party to this Agreement, except for the
holders of Registrable Securities as a result of a transfer conducted in
accordance with the provisions of Section 5.9 hereof.

          6.12 The Company acknowledges and agrees that irreparable damage would
occur in the event that any of the provisions of Article V of this Agreement
were not performed in accordance with its specific terms or were otherwise
breached and that such damage would not be compensable in money damages and that
it would be extremely difficult or impracticable to measure the resultant
damages. Accordingly, that any Subscriber shall be entitled to an injunction or
injunctions with respect to the provisions of this Agreement and to enforce

                                     -19-

<PAGE>

specifically the terms and provisions hereof, in addition to any other remedy to
which it may be entitled at law or in equity, and the Company expressly waives
any defense that a remedy in damages would be adequate and expressly waives any
requirement in an action for specific performance for the posting of a bond by
the Subscriber bringing such action.

                 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                     -20-

<PAGE>

[Signature Page]

NUMBER OF UNITS ___________ X $100,000 = ______________ (the "Purchase Price")

------------------------------     -----------------------------------
Signature                          Signature (if purchasing jointly)

------------------------------     -----------------------------------
Name Typed or Printed              Name Typed or Printed

------------------------------     -----------------------------------
Entity Name                        Entity Name

------------------------------     -----------------------------------
Address                            Address

------------------------------     -----------------------------------
City, State and Zip Code           City, State and Zip Code

------------------------------     -----------------------------------
Telephone-Business                 Telephone--Business

------------------------------     -----------------------------------
Telephone-Residence                Telephone--Residence

------------------------------     -----------------------------------
Facsimile-Business                 Facsimile--Business

------------------------------     -----------------------------------
Facsimile-Residence                Facsimile--Residence

------------------------------     -----------------------------------
Tax ID # or Social Security #      Tax ID # or Social Security #

Name in which securities should be issued: ___________________________

Dated:    __________________________  ___, ____

     This Subscription Agreement is agreed to and accepted as of ________, 2000.

                                   ENDOREX CORPORATION

                                   By:____________________________________

                                     -21-

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