Document:

<PAGE>
                                                                     Exhibit 4.9

                                 AMENDMENT NO. 2

                          DATED AS OF JANUARY 31, 2002

                                       TO

                              $16,000,000 364 DAY

                  CREDIT AGREEMENT DATED AS OF JANUARY 31, 2001

                                      AMONG

                          GENENCOR INTERNATIONAL, INC.,

                            THE LENDERS PARTY THERETO

                                       AND

                              JPMORGAN CHASE BANK
                             AS ADMINISTRATIVE AGENT

                                       PREPARED BY:
                                       ------------
                                       Underberg & Kessler LLP
                                       Counsel to the Administrative Agent
                                       Michael C. Dwyer, Esq.
                                       1800 Chase Square
                                       Rochester, New York 14604
                                       Telephone: (585) 258-2825
                                       Fax: (585) 258-2821
                                       E-mail: mdwyer@underberg-kessler.com
                                               ----------------------------

<PAGE>

                       AMENDMENT NO. 2 TO CREDIT AGREEMENT
                       -----------------------------------

         AGREEMENT dated as of January 31, 2002, among GENENCOR INTERNATIONAL,
INC. (the "BORROWER"), the Lenders signatory to this Amendment (each a "LENDER")
and JPMORGAN CHASE BANK, formerly known as THE CHASE MANHATTAN BANK, as
Administrative Agent for the Lenders (in such capacity, together with its
successors in such capacity, the "ADMINISTRATIVE AGENT").

                                    RECITALS
                                    --------

         R.1 The Borrower, JPMorgan Chase Bank, individually and as
Administrative Agent, ABN Amro Bank N.V. and The Bank of New York entered into a
$16,000,000 364-Day Credit Agreement, dated as of January 31, 2001 (the "CREDIT
AGREEMENT").

         R.2 Pursuant to the terms of that certain Amendment No. 1 to Credit
Agreement dated as of April 20, 2001, the parties hereto amended the Credit
Agreement to: (i) increase the aggregate amount of the Commitments to
$20,000,000, (ii) to add Credit Suisse First Boston as a Lender, and (iii) to
amend certain other general terms of the Credit Agreement.

         R.3 The Borrower desires to further amend the Credit Agreement to
extend the Maturity Date and to amend the Credit Agreement on the terms and
conditions set forth below.

         NOW, THEREFORE, the parties agree as follows:

         1. DEFINITIONS. Except as otherwise set forth herein, as used in this
Amendment, the terms defined in the Credit Agreement shall have the meanings
assigned to them in the Credit Agreement.

         2. AMENDMENTS. The Credit Agreement is hereby amended as set forth
below:

         2.1 ADDITIONAL DEFINITION. The following definition is added to SECTION
1.01 of the Credit Agreement:

                                        2
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         "AMENDMENT NO. 2 shall mean Amendment No. 2 dated as of January 31,
         2002 to Credit Agreement dated as of January 31, 2001."

         2.2 DEFINITION - MATURITY DATE. The definition of Maturity Date in
SECTION 1.01 is amended to read as follows:

         "MATURITY DATE means January 30, 2003."

         2.3 AMENDMENT - THE CHASE MANHATTAN BANK. All references in the Credit
Agreement to "The Chase Manhattan Bank", or "Chase", shall be deemed to refer to
JPMorgan Chase Bank.

         3. REPRESENTATIONS AND WARRANTIES. Borrower hereby represents and
warrants to the Lenders that:

         3.1 CORPORATE POWER AND AUTHORITY: NO CONFLICTS. The execution,
delivery and performance by the Borrower of this Amendment have been duly
authorized by all necessary corporate action and do not and will not: (a)
require any consent or approval of its shareholders, which has not been
obtained; (b) contravene its charter or by-laws, as amended to date; (c) violate
any provision of, or require any filing, registration, consent or approval
under, any law, rule, regulation, order, writ, judgment, injunction, decree,
determination or award presently in effect having applicability to the Borrower
or any of its Subsidiaries or Affiliates; (d) result in a breach of or
constitute a default or require any consent that has not been obtained under any
indenture or loan or credit agreement or any other agreement, lease or
instrument to which the Borrower is a party or by which it or its properties may
be bound or affected; (e) result in, or require, the creation or imposition of
any Lien, upon or with respect to any of the properties now owned or hereafter
acquired by the Borrower and its Subsidiaries; or (f) cause the Borrower (or any
Subsidiary or Affiliate, as the case may be), to be in default under any such
law, rule, regulation, order, writ, judgment, injunction, decreed, determination
or award of any such indenture, agreement, lease or instrument.

         3.2 LEGALLY ENFORCEABLE AGREEMENT. This Agreement, and the Credit
Agreement as amended hereby, are the legal, valid and binding obligations of the
Borrower enforceable against the Borrower in accordance with their respective
terms, except to the extent that such

                                       3
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enforcement might be limited by applicable bankruptcy, insolvency or other
similar laws affecting creditors' rights generally.

         3.3 NO DEFAULT. On and of the date of this Amendment, and after giving
effect to this Amendment, no event has occurred and is continuing which
constitutes a Default or Event of Default.

         3.4 REPRESENTATIONS AND WARRANTIES. All representations and warranties
contained in the Credit Agreement are true and correct as of the date of this
Amendment as if fully set forth herein and made on and as of the date of this
Amendment. The Borrower has heretofore furnished to Lenders its consolidated
balance sheet and statements of income, stockholders' equity and cash flows as
of and for the fiscal year ended December 31, 2000, reported on by
PricewaterhouseCoopers LLP, independent public accountants. Such financial
statements present fairly, in all material respects, the financial position and
results of operations and cash flows of the Borrower and its Subsidiaries as of
such date and for such period in accordance with GAAP.

         3.5 MATERIAL/ADVERSE CHANGE. Since December 31, 2000, there has been no
material adverse change in the condition (financial or otherwise), business,
operations or prospects of the Borrower and its Subsidiaries, taken as a whole.

         4. EFFECTIVENESS. This Amendment shall be of no force or effect unless
and until the later of January 21, 2002 or the date on which all of the
following conditions are met:

         4.1 COUNTERPARTS. The Borrower and the Administrative Agent shall have
each received counterparts of this Amendment duly executed by the Borrower, the
Administrative Agent, and all of the Lenders.

         4.2 RESOLUTIONS. The Administrative Agent shall have received certified
copies of the resolutions of the board of directors of the Borrower, in form and
content reasonably satisfactory to the Administrative Agent, authorizing the
execution, delivery and performance of this Amendment.

         5. EXPENSES. Borrower agrees to pay JPMorgan Chase Bank ("CHASE") for
all costs, expenses and charges (including, without limitation, fees and charges
of

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external legal counsel for Chase and costs allocated by its internal legal
department) incurred by Chase in connection with the negotiation, preparation
and execution of this Amendment and other documents executed in connection
herewith.

         6. MISCELLANEOUS. Except as expressly provided in this Amendment, the
Credit Agreement shall remain unchanged and in full force and effect, except
that each reference in the Credit Agreement, and in any agreements, certificates
and notices simultaneously herewith or hereafter executed under or pursuant to
the Credit Agreement, to the "Credit Agreement", "this Agreement", "hereof",
"herein" and similar terms referring to the Credit Agreement, shall be deemed to
refer to the Credit Agreement as amended by this Amendment.

         This amendment shall be governed by and construed in accordance with
the laws of the State of New York applicable to contracts made and to be
performed in such state, without regard to conflict of laws principles.

         The section headings in this Amendment are inserted for convenience
only and shall not be part of this instrument.

         This Amendment may be signed in any number of counterparts, each of
which shall be an original, with the same effect as if the signature thereto and
hereto were upon the same instrument.

                      SIGNATURE PAGES S-1 TO S-5 TO FOLLOW

                                       5
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                                                                             S-1

         IN WITNESS WHEREOF, the parties have caused this Amendment to be
executed as of the date first above written.

                                        GENENCOR INTERNATIONAL, INC.

                                   By:    /s/  Raymond J. Land
                                          --------------------------------------

                                   Name:  Raymond J. Land
                                          --------------------------------------

                                   Title: Senior Vice President
                                          & Chief Financial Officer
                                          --------------------------------------

                                       6
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                                                                             S-2

                                   JPMORGAN CHASE BANK, INDIVIDUALLY AND
                                   AS ADMINISTRATIVE AGENT

                                 By: /s/ Scott Rose
                                    ------------------------------------------
                                     Name:  Scott Rose
                                     Title:  Vice President

                                       7
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                                                                             S-3

                                     BANKS:
                                     ------

                                     ABN AMRO BANK N.V.

                               By:     /s/  Craig W. Trautwein
                                       -----------------------------------------
                                       Name:  Craig W. Trautwein
                                       Title:  Vice President

                               By:     /s/  Todd J. Miller
                                       -----------------------------------------
                                       Name:  Todd J. Miller
                                       Title:  Credit Officer

                                       8
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                                                                             S-4

                                      BANKS
                                      -----

                                      THE BANK OF NEW YORK

                                By:     /s/  David S. Csatari
                                        ----------------------------------------
                                        Name:  David S. Csatari
                                        Title: Assistant vice President

                                       9
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                                                                             S-5

                                     BANKS:
                                     ------

                                     CREDIT SUISSE FIRST BOSTON

                              By:      /s/  William S. Lutkins
                                    --------------------------------------------
                                       Name:  William S. Lutkins
                                       Title:  Director

                               By:   /s/ Robert Heto
                                    --------------------------------------------
                                       Name:  Robert Heto
                                       Title:  Director

                                       10<PAGE>
                                                                    Exhibit 4.10

                                January 31, 2002

Genencor International, Inc.
200 Meridian Centre Boulevard
Rochester, New York 14618
Attn: Andrew P. Ashworth, Global Treasurer

         Re: Credit Agreements dated as of January 31, 2001 - Acquisition of
             Enzyme Bio-Systems

Dear Mr. Ashworth:

         Reference is made to the following Credit Agreements dated as of
January 31, 2001, each of which is among Genencor International, Inc., as
Borrower, and JPMorgan Chase Bank (formerly The Chase Manhattan Bank),
Individually and as Administrative Agent, ABN AMRO Bank N.V., The Bank of New
York and Credit Suisse First Boston, as Lenders:

         a. $16,000,000 364-day Credit Agreement, as amended by Amendment No. 1
dated as of April 20, 2001 and by Amendment No. 2 dated as of January 31, 2002
(as so amended the "364-DAY CREDIT AGREEMENT"); and

         b. $32,000,000 3 Year Credit Agreement, as amended by Amendment No. 1
dated as of April 20, 2001 (as so amended, the "3 YEAR CREDIT AGREEMENT").

         Each of the 364-Day Credit Agreement and the 3 Year Credit Agreement is
hereinafter sometimes referred to as a "CREDIT AGREEMENT". Unless otherwise
defined herein, terms defined in the Credit Agreements are used herein as so
defined.

         Borrower has advised the Lenders that Borrower desires to acquire (the
"EB ACQUISITION") all of the issued and outstanding stock of Enzyme Bio-Systems
Ltd ("EB"), a wholly-owned subsidiary of Corn Products International, Inc.
Borrower has further advised the Lender as follows:

<PAGE>

Genencor International, Inc.
January 31, 2002
Page 2

1. The EB Acquisition will be completed in accordance with the letter of intent,
and attached term sheet, dated November 16, 2001, a copy of which is attached to
this letter as EXHIBIT 1, and a summary of the EB Acquisition attached to the
December 19, 2001 letter of Andrew P. Ashworth to Scott Rose, a copy of which is
attached to this letter as EXHIBIT 1A.

2. EB will be operated as a Wholly-Owned Subsidiary of Borrower. EB has no
direct or indirect Subsidiaries.

3. The Borrower will not be assuming any liabilities in the EB Acquisition
except for EB Indebtedness not to exceed $1,250,000.

4. The purchase price being paid by Borrower in the EB Acquisition will not
exceed $37,000,000 cash (the "PURCHASE PRICE"), the payment of which will not be
financed, directly or indirectly, with (i) Loan proceeds under the 364-Day
Credit Agreement and/or (ii) Loan proceeds under the 3 Year Credit Agreement in
excess of $20,000,000. On the date of this letter and on the closing date of the
EB Acquisition, no amounts will be outstanding under the 364-Day Credit
Agreement and the principal balance outstanding under the 3 Year Credit
Agreement will not exceed $20,000,000.

5. None of the assets of EB will, after the EB Acquisition, be subject to any
Liens, except as permitted under SECTION 6.02 of each Credit Agreement.

6. No Default exists on the date hereof and the closing of the EB Acquisition
will not cause any Default on the date of closing under any provisions of either
of the Credit Agreements or the other Loan Documents, except that the payment of
the Purchase Price will constitute an Investment under clause (b) of the
definition of Permitted Investments that will exceed 10% of Consolidated Net
Worth (the "10% of Consolidated Net Worth Limitation"). Borrower has requested
that the Lenders waive the 10% of Consolidated Net Worth Limitation, as it
applies to the EB Acquisition, in order to permit Borrower to pay the Purchase
Price.

7. Borrower has provided the Lenders with certain financial information
regarding the EB Acquisition and its projected effect on Borrower.

         In reliance on the foregoing, each of the undersigned hereby waives
SECTION 6.04 of the Credit Agreements to the extent that the 10% of Consolidated
Net Worth Limitation applies to Borrower's payment of the Purchase Price. This
waiver shall be subject to the following:

       A. The closing of the EB Acquisition must be consistent with the terms
of EXHIBITS 1 AND 1A.

<PAGE>

Genencor International, Inc.
January 31, 2002
Page 3

      B. The Lenders shall have received a Guarantee of EB, in form
acceptable to the Required Lenders, of all Indebtedness of the Borrower to the
Lenders, in compliance with SECTION 5.09 of each Credit Agreement, along with
the other documentation required by SECTION 5.09 with respect to such Guarantee.

      C. With each report furnished by the Borrower to the Administrative
Agent and each Lender pursuant to SECTION 5.01(C) of each Credit Agreement, the
Borrower will submit a report, in form satisfactory to the Administrative Agent,
indicating the following:

         1. The initial amount, and any additional amounts, of each Permitted
Investment made after January 31, 2001, the nature and form of each such
Investment and the total initial cost of all such Investments and additional
amounts.

         2. The Purchase Price paid as of the reporting date.

         3. The 10% of Consolidated Net Worth Limitation as of the reporting
date.

      D. The statements set forth in PARAGRAPHS 1 THROUGH 7 above shall be
complete and accurate and Borrower shall have received all approvals and
consents required in order to complete the EB Acquisition, including any
required pursuant to the Note Agreement.

      The foregoing constitutes the entire agreement of the undersigned in
connection with the EB Acquisition. The undersigned have not agreed to any
consent, waiver or amendment with respect to the Loan Documents, or to any
transaction, except as specifically provided above; and except as so provided,
the Loan Documents shall remain in full force and effect in accordance with
their terms.

         This letter shall not have any force or effect until you execute two
(2) copies of this letter in the blank provided after the close hereof and
return them to the Administrative Agent, in order to affirm the statements set
forth in PARAGRAPHS 1 THROUGH 7 above and to indicate your acceptance of the
terms and conditions set forth herein.

                                  JPMorgan Chase Bank, Individually and as
                                  Administrative Agent

                                  By:      /s/  Scott Rose
                                           -----------------------------------
                                           Name:  Scott Rose
                                           Title:  Vice President

<PAGE>

Genencor International, Inc.
January 31, 2002
Page 4

                        ABN AMRO Bank, NV

                        By:      /s/  Craig W. Trautwein
                                 -----------------------------------
                                 Name:  Craig W. Trautwein
                                 Title:  Vice President

                        By:      /s/  Todd J. Miller
                                 -----------------------------------
                                 Name:  Todd J. Miller
                                 Title:  Credit Officer

                        The Bank of New York

                        By:      /s/  David S. Csatari
                                 ------------------------------------
                                 Name:  David S. Csatari
                                 Title: Assistant Vice President

                        Credit Suisse First Boston

                        By:      /s/  William S. Lutkins      /s/  Robert Heto
                                 -----------------------------------------------
                                 Name:  William S. Lutkins       Robert Heto
                                 Title:  Director                Director

         The statements set forth in Paragraphs 1 - 7 above are complete and
accurate and the conditions to the above waiver, and the agreements required of
the Borrower, set forth in the above letter are accepted and agreed to.

                        Genencor International, Inc.

                        By:      /s/  Raymond J. Land
                                 -----------------------------------
                                 Name:  Raymond J. Land
                                 Title:   Senior Vice President
                                          Chief Financial Officer

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