Document:

EX-10-52

 Exhibit 10.52 
 FIRST AMENDMENT TO LICENSE AND TECHNICAL ASSISTANCE AGREEMENT 
 This First Amendment to
License and Technical Assistance Agreement (the “Amendment”) is dated September 17, 2012 (the “Amendment Effective Date”) and amends the License and Technical Assistance Agreement dated September 10, 2010 (the
“Agreement”) by and between ABT Holding, Inc., a Delaware corporation and subsidiary of Athersys, Inc. (“Athersys”) and RTI Biologics, Inc., a Delaware corporation (“RTI”). All defined terms used but not defined in this
Amendment shall have the meanings ascribed to them in the Agreement. 
 WHEREAS, the parties have entered into the Agreement, under the terms
and conditions of which the parties continue to perform; and 
 WHEREAS, the parties wish to provide for the advance payment of a portion of the
License Fee payable under the Agreement, subject to Athersys’ provision of certain technical assistance described herein and subject to Athersys’ good faith negotiation of a new assistance agreement between the parties. 

NOW, THEREFORE, in consideration of the above premises and the mutual promises set forth below, and other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree to amend the Agreement as follows: 
  

	 	1.	RTI agrees to pay Athersys in advance the One Million Dollar ($1,000,000) portion of the License Fee payable under Section 2.1.4 of the Agreement, which shall be
due and payable as of the Amendment Effective Date. 

  

	 	2.	Athersys agrees to use commercially reasonable efforts to provide the technical assistance set forth on Exhibit A attached to this Amendment. The purpose of such
technical assistance is to provide RTI with the assistance necessary to enable RTI to complete the first implantable run of a MAPC Technology Product and, to the extent agreed to by the parties, to support further development and commercialization
efforts of MAPC Technology Products after such first implantable run. 

  

	 	a.	Subject to Athersys having used its commercially reasonable efforts to provide the technical assistance set forth in Section A.I of Exhibit A to this
Amendment prior to October 31, 2012, RTI will advance Five Hundred Thousand Dollars ($500,000) of the One Million Dollar ($1,000,000) portion of the License Fee payable under Section 2.1.5 of the Agreement on the earlier of:
(i) the date on which all such technical assistance set forth in Section A.l of Exhibit A to this Amendment has been completed; or (ii) October 31, 2012. 

 

	 	b.	Subject to Athersys having used its commercially reasonable efforts to provide the technical assistance set forth in Section A.2 of Exhibit A to this
Amendment prior to December 31, 2012, RTI will advance the remaining Five Hundred 

 Confidential 

	 	
Thousand Dollars ($500,000) of the One Million Dollar ($1,000,000) portion of the License Fee payable under Section 2.1.5 of the Agreement on the earlier of: (i) the date on
which such technical assistance under Section A.2 of Exhibit A to this Amendment has been completed; (ii) the date of first commercial implant of a MAPC Technology Product; or (iii) December 31,2012. 

 

	 	3.	Athersys agrees to negotiate in good faith the tenns of an assistance agreement with RTI under which Athersys will support further development and commercialization of
MAPC Technology Products. 

 Upon execution of this Amendment by the parties this Amendment shall be made a part of and shall be
incorporated by reference into the Agreement. All tet.ms and conditions of the Agreement not amended hereby shall remain in full force and effect and are hereby ratified by the parties. 
 IN WITNESS WHEREOF, the parties have caused this Amendment to be executed by their duly authorized representatives. 
  

							
	RTI BIOLOGICS, INC.	 	ABT HOLDING, INC.
				
	Signature:	 	/s/ Thomas F. Rose	 	Signature:	 	/s/ William O. Lehmann

							
	Name:	 	Thomas F. Rose	 	Name:	 	William O. Lehmann

							
	Title:	 	EVP-COO	 	Title:	 	President and COO

							
	Date:	 	9/17/12	 	Date:	 	9/17/2012

 2 
 Confidential 

 EXHIBIT A 
 Section A.l-Technical Assistance prior to October 31, 2012 
  

	 	1.	Athersys will finalize the transition at Progenitor Cell Therapy, LLC (“PCT”) from contract manufacturer to resident client manufacturing. The critical
support person is Amy Raber of Athersys. This includes 4 days of travel by Amy Raber to RTI to help train RTI and PCT employees in the MAPC Teclmology Product production process and also fulfills the role of “trainer” with respect to the
RTI quality documentation. In addition, Amy Raber’s participation is required in the next 2 runs of generation of MAPC Technology Product at PCT, the second of which is a production run. The production run is scheduled to commence in
mid-October and be completed by approximately November 15, 2012. 

  

	 	2.	Athersys will provide cells from the RTI cell bank for final equipment qualifications at PCT. 

 Section A.2-Technical Assistance prior to December 31, 2012 
  

	 	1.	Athersys will complete the final two areas of the Collaboration Plan (attached as Exhibit B to the Agreement) that are still in process, namely: (i) for completion
of GMP validation runs on the first 3 production runs, Athersys will provide assistance on performing both the Alizarin Red assay and T-cell proliferation assay (Immunosuppression/Non-immunogenicity) at the Athersys labs (under Objectives
#2 & 3 of Exhibit B); and (ii) Athersys will provide support by providing additional data for adopting the existing shelflife (3 year real time aging data) in Objective #4 of Exhibit B. 

 

	 	2.	Athersys and RTI will continue to work on the evaluation of ongoing animal studies that have been coordinated with Athersys. 

Section A.3-Technical Assistance subsequent to December 31, 2012 

 

	 	1.	 Athersys will continue to support supply ofMultiStem® media as required by RTI. 

  

	 	2.	After product launch of the MAPC Teclmology Product, Athersys will continue to provide technical assistance to RTI (including without limitation joint work on process
optimization) as described in an expanded Collaboration Plan which will be negotiated by the parties and which will be subject to the provisions set forth in Section 3.2 of the Agreement. 

ConfidentialFifth Amendment to Credit Agreement

 Exhibit 10.1 

 
  

 
 FIFTH AMENDMENT TO CREDIT
AGREEMENT 
 Dated as of October 9, 2012 
 among  
 GULFPORT ENERGY CORPORATION, 

as Borrower,  
 THE BANK OF NOVA SCOTIA, 
 as Administrative Agent 

and 
 L/C Issuer
and Lead Arranger, 
 and 
 AMEGY BANK NATIONAL ASSOCIATION, 
 as Syndication Agent 

and 
 KEYBANK
NATIONAL ASSOCIATION, 
 as Documentation Agent 
 and 
 The Other Lenders Party Hereto 

 
  

 

 FIFTH AMENDMENT TO CREDIT AGREEMENT 

THIS FIFTH AMENDMENT TO CREDIT AGREEMENT (the “Fifth Amendment to Credit Agreement,” or this
“Amendment”) is entered into effective as of October 9, 2012, among GULFPORT ENERGY CORPORATION, a Delaware corporation (“Borrower”), THE BANK OF NOVA SCOTIA, as Administrative Agent and
L/C Issuer (the “Administrative Agent”) and L/C Issuer (the “L/C Issuer”), and the Lenders parties hereto. 
 R E C I T A L S 

A. Borrower, the financial institutions signing as Lenders thereto and Administrative Agent are parties to a Credit Agreement dated as of
September 30, 2010, as amended by a First Amendment to Credit Agreement dated as of May 3, 2011, a Second Amendment to Credit Agreement dated as of 10:00 A.M. October 31, 2011, a Third Amendment to Credit Agreement dated as of
12:00 P.M. October 31, 2011, and a Fourth Amendment to Credit Agreement dated as of May 2, 2012 (collectively, the “Original Credit Agreement”). 

B. The parties desire to amend the Original Credit Agreement as hereinafter provided. 

NOW, THEREFORE, in consideration of these premises and for other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the parties hereto agree as follows: 
 1. Same Terms. All terms used herein that are
defined in the Original Credit Agreement shall have the same meanings when used herein, unless the context hereof otherwise requires or provides. In addition, (i) all references in the Oil and Gas Mortgages, Affidavit of Payment of Trade Bills,
Property Certificate, Reconciliation Schedule and Title Indemnity Agreement to the “Credit Agreement” and in the Credit Agreement and the other Loan Documents to the “Agreement” shall mean the Original Credit Agreement, as
amended by this Amendment, as the same may hereafter be amended from time to time, and (ii) all references in the Loan Documents to the “Loan Documents” shall mean the Loan Documents, as amended by the Modification Papers, as the same
may hereafter be amended from time to time. In addition, the following terms have the meanings set forth below: 

“Effective Date” means noon CDT on October 9, 2012. 

“Modification Papers” means this Amendment, and all of the other documents and agreements executed in connection
with the transactions contemplated by this Amendment. 
 2. Conditions Precedent. The obligations and agreements
of the Lenders as set forth in this Amendment are subject to the satisfaction, unless waived in writing by Administrative Agent, of each of the following conditions (and upon such satisfaction, this Amendment shall be deemed to be effective as of
the Effective Date): 
 A. Fifth Amendment to Credit Agreement. This Amendment shall have been
duly executed and delivered by Borrower and Majority Lenders. 
 B. Fees and Expenses.
Administrative Agent shall have received payment of all out-of-pocket fees and expenses (including reasonable attorneys’ fees and expenses) incurred by Administrative Agent in connection with the preparation, negotiation and execution of the
Modification Papers. 

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Page 1 

 C. Representations and Warranties. All representations and
warranties contained herein or in the other Modification Papers or otherwise made in writing in connection herewith or therewith shall be true and correct in all material respects (provided that any such representations or warranties that are, by
their terms, already qualified by reference to materiality shall be true and correct without regard to such materiality standard) with the same force and effect as though such representations and warranties have been made on and as of the Effective
Date, or if made as of a specific date, as of such date. 
 3. Amendments to Original Credit Agreement. On the
Effective Date, the Original Credit Agreement shall be deemed to be amended as follows: 
 (a)
Section 1.01 of the Original Credit Agreement is hereby amended by adding the following definition in appropriate alphabetical order therein: 
 “‘Senior Notes’ means any unsecured Indebtedness of Borrower (and any unsecured Guarantees thereof by the Guarantors) in an aggregate principal amount not exceeding
$300,000,000.” 
 (b) Section 4.05 of the Original Credit Agreement is hereby amended by adding
the following paragraph (e) at the end thereof: 
 “(e) in the event of an issuance of any Senior
Notes, then the then effective Borrowing Base shall be reduced immediately, automatically and without notice by an amount determined by the Required Lenders.” 

(c) Section 8.01 of the Original Credit Agreement is hereby amended by deleting the word “and” at
the end of clause (p), changing the period at the end of clause (q) to “; and”, and adding the following at the end thereof: 
 “(r) Liens arising under an indenture or other agreement governing Senior Notes in favor of the trustee, agent or representative thereunder for its own benefit; provided, however, that
such Liens are solely for the benefit of such trustee, agent or representative in its capacity as such and not for the benefit of the holders of such indebtedness.” 

(d) Section 8.03 of the Original Credit Agreement is hereby amended by deleting the word “and” at
the end of clause (n), by changing clause (o) to “(p)” and by adding the following clause as clause (o) thereto: 
 “(o) Senior Notes so long as (1) no Default exists immediately before or after giving effect to any such incurrence, (2) such Senior Notes have been issued on or before October 31,
2012, (3) the maturity date of such Senior Notes is not less than one year after the Maturity Date and (4) the indentures or other agreements under which any Senior Notes are issued and all other instruments, agreements or other documents
evidencing or governing such Senior Notes or providing for any guarantee or other right in respect thereof have terms that, taken as a whole, are not more restrictive on Borrower and its Subsidiaries than the terms of this Agreement and the other
Loan Documents; and” 

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Page 2 

 (e) Section 8.12 of the Original Credit Agreement is hereby
amended by deleting the word “or” between clauses (c) and (d), deleting the period at the end of clause (d), and adding the following at the end thereof: 

“, or (e) an indenture or other agreement governing Senior Notes issued in compliance with
Section 8.03.” 
 4. Certain Representations. Borrower represents and warrants that, as of the Effective Date:
(a) Borrower has full power and authority to execute the Modification Papers to which it is a party and such Modification Papers constitute the legal, valid and binding obligation of Borrower enforceable in accordance with their terms, except
as enforceability may be limited by general principles of equity and applicable bankruptcy, insolvency, reorganization, moratorium, and other similar laws affecting the enforcement of creditors’ rights generally; and (b) no authorization,
approval, consent or other action by, notice to, or filing with, any Governmental Authority or other Person is required for the execution, delivery and performance by Borrower thereof. In addition, Borrower represents that after giving effect to
this Amendment, all representations and warranties contained in the Original Credit Agreement and the other Loan Documents are true and correct in all material respects (provided that any such representations or warranties that are, by their terms,
already qualified by reference to materiality shall be true and correct without regard to such materiality standard) on and as of the Effective Date as if made on and as of such date except to the extent that any such representation or warranty
expressly relates solely to an earlier date, in which case such representation or warranty is true and correct in all material respects (or true and correct without regard to such materiality standard, as applicable) as of such earlier date.

 5. No Further Amendments. Except as previously amended or waived in writing or as amended hereby, the Original
Credit Agreement shall remain unchanged and all provisions shall remain fully effective between the parties. 
 6.
Acknowledgments and Agreements. Borrower acknowledges that on the date hereof all outstanding Obligations are payable in accordance with their terms, and Borrower waives any defense, offset, counterclaim or recoupment with respect
thereto. Borrower, Administrative Agent, L/C Issuer and each Lender do hereby adopt, ratify and confirm the Original Credit Agreement, as amended hereby, and acknowledge and agree that the Original Credit Agreement, as amended hereby, is and remains
in full force and effect. Borrower acknowledges and agrees that its liabilities and obligations under the Original Credit Agreement, as amended hereby, and under the other Loan Documents, are not impaired in any respect by this Amendment.

 7. Limitation on Agreements. The modifications set forth herein are limited precisely as written and shall not
be deemed (a) to be a consent under or a waiver of or an amendment to any other term or condition in the Original Credit Agreement or any of the Loan Documents, or (b) to prejudice any right or rights that Administrative Agent now has or
may have in the future under or in connection with the Original Credit Agreement and the other Loan Documents, each as amended hereby, or any of the other documents referred to herein or therein. The Modification Papers shall constitute Loan
Documents for all purposes. 
 8. Confirmation of Security. Borrower hereby confirms and agrees that all of the
Collateral Documents that presently secure the Obligations shall continue to secure, in the same manner and to the same extent provided therein, the payment and performance of the Obligations as described in the Original Credit Agreement as modified
by this Amendment. 
 9. Counterparts. This Amendment may be executed in any number of counterparts, each of which
when executed and delivered shall be deemed an original, but all of which constitute one instrument. In making proof of this Amendment, it shall not be necessary to produce or account for more than one counterpart thereof signed by each of the
parties hereto. 

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Page 3 

 10. Incorporation of Certain Provisions by Reference. The provisions of
Section 11.15. of the Original Credit Agreement captioned “Governing Law, Jurisdiction; Etc.” and Section 11.16. of the Original Credit Agreement captioned “Waiver of Right to Trial by Jury” are incorporated herein by
reference for all purposes. 
 11. Entirety, Etc. This Amendment, the other Modification Papers and all of the
other Loan Documents embody the entire agreement between the parties. THIS AMENDMENT, THE OTHER MODIFICATION PAPERS AND ALL OF THE OTHER LOAN DOCUMENTS REPRESENT THE FINAL AGREEMENT AMONG THE PARTIES AND MAY NOT BE CONTRADICTED BY EVIDENCE OF PRIOR,
CONTEMPORANEOUS OR SUBSEQUENT ORAL AGREEMENTS OF THE PARTIES. THERE ARE NO UNWRITTEN ORAL AGREEMENTS AMONG THE PARTIES. 

[This space is left intentionally blank. Signature pages follow.] 

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Page 4 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment to be effective as of
the date and year first above written. 
  

			
	 BORROWER
  

GULFPORT ENERGY CORPORATION

		
	By:	 	/s/ Michael G. Moore
		 	Name: Michael G. Moore
		 	Title:   Vice President and CFO

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page 

 
					
	 ADMINISTRATIVE AGENT
  

THE BANK OF NOVA SCOTIA,
 as
Administrative Agent

		
	By:	 	/s/ Marc Graham
		 	Name:	 	Marc Graham
		 	Title:	 	Director

  

					
	 THE BANK OF NOVA SCOTIA,
 as Lender

		
	By:	 	/s/ Marc Graham
		 	Name:	 	Marc Graham
		 	Title:	 	Director

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page 

 
			
	AMEGY BANK NATIONAL ASSOCIATION
		
	By:	 	/s/ JB Askew
		 	Name: JB Askew
		 	Title:   Assistant Vice President

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page 

 
					
	KEYBANK NATIONAL ASSOCIATION 
		
	By:	 	 
		 	Name:	 	 
		 	Title:	 	 

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page 

 
					
	TEXAS CAPITAL BANK, N.A.
		
	By:	 	 
		 	Name:	 	 
		 	Title:	 	 

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page 

 
					
	 CREDIT SUISSE AG,
 Cayman Islands Branch

		
	By:	 	 
		 	Name:	 	 
		 	Title:	 	 
		
	By:	 	 
		 	Name:	 	 
		 	Title:	 	 

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page 

 
			
	 DEUTSCHE BANK TRUST COMPANY
 AMERICAS

		
	By:	 	/s/ Michael Getz
		 	Name: Michael Getz
		 	Title: Vice President

  

			
	By:	 	/s/ Courtney E. Meehan
		 	Name: Courtney E. Meehan
		 	Title: Vice President

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page 

 
			
	IBERIABANK
		
	By:	 	/s/ W. Bryan Chapman
		 	Name: W. Bryan Chapman
		 	Title: Executive Vice President

  
 FIFTH AMENDMENT TO
CREDIT AGREEMENT – Signature Page

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00208-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00208-of-00352.parquet"}]]