Document:

March 31, 2000

Stephen J. Sullivan
[ADDRESS INTENTIONALLY LEFT BLANK]

      RE:  AMENDMENT NO. 1 TO EMPLOYMENT LETTER AGREEMENT (THE "AGREEMENT")

Dear Steve:

Please refer to that certain Employment Letter Agreement dated May 21, 1999
between Covance Inc. ("Covance" or, the "Company") and you (the "Letter
Agreement"). In order to provide you with additional consideration for your
relocation to the Princeton, New Jersey area, Covance has agreed to amend the
Letter Agreement to provide you with certain additional benefits. This letter
will constitute Amendment No. 1 to the Letter Agreement and will amend the
Letter Agreement as follows (any capitalized terms which are not defined herein
are used herein as defined in the Letter Agreement):

1.    The Section entitled "Change-of-Control" in the letter Agreement shall be
deleted in its entirety and a section entitled "Severance" shall be inserted in
replacement thereof as follows:

SEVERANCE

Except as provided below under the paragraph headed "CHANGE-OF-CONTROL", should
you be involuntarily terminated for reasons other than for Cause, the Company
shall pay you the following:

      (i)   an amount equal to the sum of (a) one year of base salary (payable
on the normal payroll cycle) determined at the time of termination and (b) one
year of the annual incentive bonus (payable on the normal bonus cycle) in an
amount equal for such year to the product of your base salary in effect at
termination and 60% (the sum of (a) and (b) being, collectively, the
"Termination Payments");

      (ii)  during the period between the first anniversary of the date of the
involuntary termination of your employment with the Company for reasons other
than Cause and the second anniversary of such event, your base salary (payable
on the normal payroll cycle) with the Company determined at the time of such
involuntary termination in the event that, after reasonable efforts by you, you
have been unable to obtain a suitable alternative vocation, as determined by
Company's Chief Executive Officer in his sole discretion;

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                                                                   31 March 2000
                                                                          Page 2

      (iii) your financial counseling and automobile allowance for the one year
period starting on the date of your involuntary termination from the Company for
reasons other than Cause and the first anniversary of the date of such event on
the terms and conditions of the Section of the Letter Agreement entitled "AUTO
AND FINANCIAL COUNSELING ALLOWANCE"; and

      (iv)  you shall be entitled to make the COBRA election for continued
medical and dental health insurance benefits for you and your eligible
dependents, subject to the terms and conditions of the applicable policies and
all COBRA requirements, for up to 18 months after the date of your termination
of employment. In the event you elect COBRA continuation, and such termination
was involuntary for reasons other than Cause, the Company shall pay you an
amount equal to the monthly premium for such coverage, less usual withholding
taxes and other customary withholdings, from the date of such involuntary
termination for reasons other than Cause until the date that is the later of (x)
the first anniversary of such involuntary termination and (y) the date you have
obtained a suitable alternative vocation, as determined in accordance with
Section 1(ii) hereof (such period, not to exceed 18 months after the date of
your involuntary termination from the Company for reasons other than Cause,
being the "Health Continuation Period"). For the remainder of such 18 month
period, if applicable, you shall be responsible for such costs. If you have not
found a suitable alternative vocation, as determined in accordance with Section
1(ii) hereof on or prior to the date that is 18 months after your involuntary
termination from the Company for reasons other than Cause, then the Company
shall continue paying to you the foregoing premium payments until the earlier of
(I) the date you find a suitable alternative vocation, as determined in
accordance with Section 1(ii) hereof and (II) the date that is the second
anniversary of your involuntary termination from the Company for reasons other
than Cause. Such payments will be made to you in equal installments on the dates
during the Health Continuation Period, or such later period, as applicable, that
Covance makes its regular payroll payments. In the event you were terminated for
Cause and the COBRA election is still available to you under applicable law, and
you so elect the COBRA continuation, you shall be responsible for all health
benefit premium costs. Life insurance coverage will continue, at the Company's
expense, for the period during which the Company pays the premiums for health
coverage provided above.

Notwithstanding anything in this Section 1 to the contrary, you agree that if
you obtain or are provided with medical, dental and life insurance from a new
employment position which provides comparable coverage and benefits to that
provided by the Company under the respective Company benefit plans and at an
equivalent or lesser expense (both deductible and direct) to you, then you shall
promptly notify the Company which of such insurance benefits is then being
provided to you and the Company shall cease providing such coverage or
discontinue paying the premiums for such insurance, as applicable.

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                                                                   31 March 2000
                                                                          Page 3

If there has been an Event of Termination (as defined below) or should you be
involuntarily terminated for reasons other than Cause (as defined below), at any
time prior to two years from the date of your business and residential
relocation to the Princeton, NJ area, Covance will reimburse you for the costs,
expenses and fees of moving your household goods from the Princeton, NJ area to
Illinois, as well as the travel expenses of your immediate family, all in
accordance with applicable Covance transfer policies and upon submission of
proper documentation.

Please refer to that certain Confidentiality and Non-Competition Agreement
between you and the Company (the "Non-Competition Agreement"). You agree that
any of the severance payments under Section 1(i) or (ii) of this Letter
Agreement shall constitute the payment of your base salary under Section
4(a)(ii) of the Non-Competition Agreement.

"CAUSE" shall mean (i) your convictions of a felony or a misdemeanor if such
misdemeanor involves moral turpitude; (ii) your committing any act of gross
negligence or intentional misconduct in the performance or non-performance of
your duties as an employee of Covance or its affiliates, including, any actions
which constitute sexual harassment under applicable laws, rules or regulations;
(iii) your failure to perform your duties assigned for a period of thirty (30)
or more days unless such failure is caused by an Extended Disability; or (iv)
misappropriation of assets, personal dishonesty or intentional misrepresentation
of facts which may cause Covance or its affiliates financial or reputational
harm.

Notwithstanding anything else in the Letter Agreement to the contrary, in the
event that you do not relocate your business and domestic residence to the
Princeton, New Jersey area on or before September 30, 2000 or such later date as
the Company's Chief Executive Officer may determine in his sole discretion and
you are terminated as a result of such failure, you shall not be entitled to the
severance benefits specified under SEVERANCE in Section 1 hereof; PROVIDED,
HOWEVER, that if you have not relocated as specified above on or prior to the
occurrence of a Change-of-Control (as defined below) and a Change-of-Control
shall occur, then you shall not be required to relocate and any request to
relocate shall be considered a Constructive Termination, all as specified more
fully below under the Section "CHANGE-OF-CONTROL" below.

Should your employment be terminated by Covance because of an Extended
Disability (as defined below), and not for any other reason that constitutes
Cause, for 120 consecutive days where you have not returned to your duties on a
full-time basis after the expiration of such 120 day period within 30 days after
written notice of termination is given to you, Covance shall pay to you an
amount equal to the sum of (a) two years base salary (payable on the normal
payroll cycle) determined at the time of termination, and (b) two years of the
annual incentive bonus (payable on the normal bonus cycles) in an amount equal
for each such year to the product of your base salary in effect at termination
and 60% (the sum of (a) and (b) being, collectively, the "Extended Disability
Payments").

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                                                                   31 March 2000
                                                                          Page 4

EXTENDED DISABILITY shall (i) mean you are unable, as a result of a medically
determinable physical or mental impairment, to perform the duties and services
of your position, or (ii) have the meaning specified in any disability insurance
policy maintained by Covance, whichever is more favorable to you.

Except as may be otherwise provided in applicable Covance compensation and
benefit plans, Covance shall not be liable for any salary or benefit payments to
you beyond the date of your voluntary termination of employment with Covance. In
the event of a termination of employment for Cause or Extended Disability, you
shall not be entitled to any compensation or other benefits not already earned
and owing to you on account of your services on the date of such termination of
employment except as provided above with respect to a termination for Extended
Disability. The provision of any benefits pursuant to this Agreement shall be in
lieu of, and not in addition to, any payment or benefits you otherwise would
have been entitled to pursuant to any severance pay plan of Company, including,
without limitation, that certain Amended and Restated Severance Pay Plan.

CHANGE-OF-CONTROL

In the event of an Event of Termination (as defined below), you will be entitled
to a lump sum payment equal to the sum of (1) the product of (a) 3 and (b) your
base annual salary in effect at the time of the Event of Termination and (2) the
product of (a) 3 and (b) number that is 60% of your base annual salary in effect
at the time of the Event of Termination. Such payment will be made within 60
days of the Event of Termination. In addition to, and as a result of, the
foregoing (i) all of your stock options, restricted stock, deferred compensation
and similar benefits which have not become vested on the date of an Event of
Termination shall become vested upon such event and (ii) you shall be entitled
to receive any payments calculated pursuant to the paragraph headed "CERTAIN
ADDITIONAL PAYMENTS BY COVANCE".

For the purposes of this Agreement, an Event of Termination is defined to be a
termination of your employment by Covance (for reasons other than Cause) or a
Constructive Termination (as defined below) of your employment, in each case
within 24 months following a Change-of-Control (as defined below), or your
voluntary termination of your employment for any reason or no reason during the
one-month period commencing twelve months following a Change-of-Control and
ending thirteen months after such Change-of-Control (a "Voluntary Termination");
PROVIDED, HOWEVER, that a Voluntary Termination shall not be an Event of
Termination if it arises from a Change-of-Control pursuant to clause (iv) under
the definition of Change-of-Control unless the tender offer or exchange offer is
a tender or exchange offer for securities representing 20% or more of the
combined voting power of Covance's then outstanding securities.

For purposes of this Agreement, a Change-of-Control is defined to occur when:

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                                                                   31 March 2000
                                                                          Page 5

      (i)   any person (including as such term is used in Section 13(d) and
14(d)(2) of the Securities Exchange Act of 1934) becomes the beneficial owner,
directly or indirectly, of Covance's securities representing 20% or more of the
combined voting power of Covance's then outstanding securities; or

      (ii)  as a result of a proxy contest or contests or other forms of
contested shareholder votes (in each case either individually or in the
aggregate), a majority of the individuals elected to serve on Covance's Board of
Directors are different than the individuals who served on Covance's Board of
Directors at any time within the two years prior to such proxy contest or
contests or other forms of contested shareholder votes (in each case either
individually or in the aggregate); or

      (iii) Covance shareholders approve a merger, or consolidation (where in
each case Covance is not the survivor thereof), or sale or disposition of all or
substantially all of Covance's assets or a plan or partial or complete
liquidation; or

      (iv)  an offeror (other than Covance) purchases shares of Covance common
stock pursuant to a tender or exchange offer for such shares.

For purposes of this Agreement, a Constructive Termination is defined to be:

      (i)   a material breach by Covance of this Agreement, including, without
limitation, a reduction in your then current salary or the percentage of base
salary eligible for incentive compensation;

      (ii)  a diminution of your responsibilities, status, title or duties
hereunder;

      (iii) a relocation of your work place which increases the distance between
your principal residence and your work place by more than 25 miles;

      (iv)  a failure by Covance to provide you with benefits which are as
favorable to you in all material respects as those provided immediately prior to
the Change-of- Control; or

      (v)   the failure of any acquiror or successor in interest to the business
of Covance to agree in writing to be bound by the terms of this Agreement within
four months of any Change-of-Control.

In the event you are involved in any dispute about your rights under this
Agreement arising on or after a Change-of-Control, Covance shall pay all legal
costs and fees incurred by you in connection with such dispute promptly upon
receipt of any invoice relating thereto.

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                                                                   31 March 2000
                                                                          Page 6

With respect to an Event of Termination, the benefits set forth under the
paragraph headed AUTO AND FINANCIAL COUNSELING Allowance and medical, dental,
disability and life insurance will be continued, to the extent they are not
otherwise prohibited under the respective plans, until you find other employment
but not longer than three years from the date of the Event of Termination.

2.    The Section  entitled  "Release"  shall be amended to read in
its entirety as follows:

RELEASE

If there has been an Event of Termination or if there has been no
Change-of-Control but you have been terminated without Cause, the obligation of
Covance to make to you any or all of the payments specified under this Agreement
(including, without limitation, the Termination Payments, the salary
continuation payments described in Section 1(ii) of this Letter Agreement or the
payments specified under the paragraph headed "CHANGE OF CONTROL", as
applicable) shall be subject to your execution and delivery to Covance of a
release in form and substance reasonably satisfactory to Covance of all claims,
demands, suits or actions, whether in law or at equity, you have or may have
relating to or giving rise from such Event of Termination or non-Cause
termination.

3.    Except as expressly  modified  hereby,  the Letter  Agreement
shall remain in full force and effect.

Please indicate your agreement with the terms and conditions of this Amendment
No. 1 by signing one copy of this letter and returning it to my attention.

Very truly yours,

Christopher A. Kuebler
President and CEO

Accepted as of the date first above specified:

By:  _________________________

                                                                               6COVANCE WAY

                                  COVANCE INC.

                           VARIABLE COMPENSATION PLAN

1. PURPOSE. The purpose of the Covance Inc. Variable Compensation Plan (as
amended, modified or supplemented, from time to time, the "Plan") is to reward
participating employees of Covance Inc. ("Covance") and its subsidiaries
(collectively, the "Company") for the attainment of superior performance. The
Plan does not constitute an amendment, supplement or modification of any
individual employment agreement between the Company and an employee or to that
certain Asset Purchase Agreement dated as of March 15, 1996 among Covance and
the parties specified therein with respect to the earning or payment of variable
or bonus compensation.

2. ELIGIBILITY. Variable compensation awards under the Plan may be made to
individuals who are full-time employees of the Company (including executives or
managers of the Company) PROVIDED, that (1) the employee is employed with the
Company on or before October 1 of the performance year in question, except as
specified below, and (2) the employee is employed by the Company both as of
December 31 of the performance year in question and on the date that the
variable compensation award for the performance year in question is actually
paid, except as specified below; PROVIDED, FURTHER, that (a) with respect to
clause (1) above, in the event an individual is employed by the Company (i) on
or after October 1 for the performance year in question but otherwise satisfies
the eligibility or performance requirements of the Plan, then (x) in the case of
individuals who are Corporate Vice Presidents of the Company or higher elected
officer positions, the Committee may approve a variable compensation award for
such individual based on the chief executive officer's ("CEO") recommendation or
(y) in the case of all other employees of the Company the CEO may approve a
variable compensation award for such individual or (ii) after January 1 of the
performance year in question but before October 1 of such year and otherwise
satisfies the eligibility or performance requirements

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of the Plan, then such employee's variable compensation award, if any, shall be
prorated based on the actual service provided by the employee for the
performance year in question based either on time worked or base pay earned and
(b) with respect to clause (2) above, in the event any employee who leaves the
Company during the performance year in question or prior to the date the
variable compensation award for such performance year is paid, in each case as a
result of death, disability or retirement with the consent of Covance, any such
award or payment shall be prorated based on actual service provided by the
employee for the performance year in question based on time worked or base pay
earned in the performance year in question. In all cases any variable
compensation awards under the Plan will be based on actual service provided by
the employee for the performance year in question based on time worked or base
pay earned in the performance year in question. Employees of the Company who
participate in other compensation plans of the Company, the terms of which
directly or indirectly exclude participation in or benefit from the Plan, shall
not be eligible for awards under the Plan. The term "subsidiary" means any
corporation in an unbroken chain descending from the parent company, where each
corporation, other than the last in the chain, owns stock possessing fifty
percent (50%) or more of the total combined voting power of all classes of stock
in one of the other corporations in the chain.

3. ADMINISTRATION/DISPUTES. The Compensation and Organization Committee of the
Covance Board of Directors (the "Committee"), or a subcommittee of such
committee, consisting of at least two members who qualify as outside directors
under applicable Internal Revenue Code and Securities and Exchange Commission
(the "SEC") rules, codes and regulations, shall manage and administer the Plan.
No member of the Committee shall be eligible for awards under the Plan. The
Committee may adopt policies, rules and regulations that it deems necessary for
governing, managing or administering the Plan. It may take action either by a
majority vote of its members in attendance provided there is a quorum, or by an
instrument in writing signed by all members without a meeting. Members of the
Committee shall not be liable for any act or

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omission in their capacities as such members, except for bad faith, gross
negligence or intentional misconduct or inaction. Any dispute or disagreement
which shall arise under, or as a result of, or pursuant to, this Plan shall be
finally determined by the Committee in its absolute and uncontrolled discretion,
and any such determination or any other determination by the Committee under or
pursuant to this Plan and any interpretation by the Committee of the terms of
this Plan, shall be final, binding and conclusive on all persons affected
thereby.

4. PERFORMANCE YEAR. Each consecutive twelve month period from January 1 through
December 31 shall be treated as a separate performance year for the purpose of
the Plan.

5. COVANCE BONUS POOL/FINANCIAL TARGETS. The Committee shall approve at the
beginning of each performance year in question, or as soon as practicable
thereafter, but in no event later than the date that is 90 days after the
beginning of such performance year, financial target(s) for the Company, such as
pre-tax/pre-bonus income, and the related minimum and maximum aggregate amount
of money available for variable compensation under the Plan and the target
aggregate variable compensation awards in each case based on such financial
target or targets (the "Bonus Pool"). The Bonus Pool shall be allocated among
Covance's corporate group (such group, other than the CEO and executive
management (including the Corporate Senior Vice Presidents), being, "Covance
Corporate"), various divisions, Business Units, Operating Groups and Investment
Units (as defined in Paragraph 7), if any, and the CEO and executive management
(including the Corporate Senior Vice Presidents) as specified in Paragraph 8.

6. FINANCIAL TARGETS. (a) EXECUTIVE/BUSINESS UNITS/OPERATING GROUPS/FINANCIAL
TARGETS. Within the time limit specified in Paragraph 5, the CEO shall approve
the financial targets to be achieved during the performance year for each
Business Unit or Operating Group of the Company (including the Investment Units,
as defined in

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Paragraph 7). Examples of such financial targets include, revenue, pre-bonus
operating margin, pre-tax income, earnings per share and backlog. Such financial
target(s) may be applicable to all of the Company or only to the Business Unit
or Operating Group or Investment Unit.

    (b) INDIVIDUALS. (i) OBJECTIVES. Within the time period specified in
Paragraph 5, the Committee shall approve the objectives for the performance year
in question of the CEO and the CEO shall approve the objectives of his direct
reports, including the Corporate Senior Vice Presidents. In the case of the CEO
and his executive management team, including the Corporate Senior Vice
Presidents, such objectives shall be based on a variety of criteria, including
financial performance, such as operating margin, pre-tax, pre-bonus operating
margin, revenue or earnings per share and other criteria which are of the
category type (as opposed to the actual objectives) determined by the CEO.

    The Committee shall also review and approve by category employees who shall
be subject to individual performance objectives for the performance year in
question. Such objectives shall be in form and substance acceptable to such
employee's supervisor or senior management, as applicable, and completed within
the time period specified in Paragraph 5. The Committee shall also designate
employees by category who shall not be required to provide such objectives.

    (ii) VARIABLE COMPENSATION TARGETS. The Committee will establish a variable
compensation target for each level of participating employee by category of
position reflected as a percentage of an employee's base pay earned during the
performance year in question (the "Employee Bonus Percentage", and the product
of an employee's base pay earned during the performance year and the applicable
Employee Bonus Percentage is, the "Employee Bonus Target Amount").

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    (iii) PERFORMANCE RATINGS. The Committee shall establish performance
assessment categories for both employees with and without objectives and the
impact, in each case, of such performance assessment on such individuals'
variable compensation award, if any, under the Plan.

7. INVESTMENT UNITS. The CEO may designate any new Business Unit as an
"Investment Unit", and for any such Investment Unit, the CEO shall approve
within the time period specified in Paragraph 5 target(s) (financial or
otherwise) for such entity for the performance year in question and the amount
of variable compensation each such Investment Unit would be eligible for in the
aggregate if its applicable financial target(s) is achieved for the performance
year in question. Such financial target(s) may be different than the targets set
for the Business Units or Operating Groups for the performance year in question.

8. COMPUTATIONS. (a) MEASUREMENT. The Committee shall certify in writing before
the payment of any variable compensation under the Plan the satisfaction of the
financial target, or portion thereof (in each case after giving effect to the
adjustments specified in Paragraphs 8(a)(1) and (2)), the amount of the Actual
Bonus Pool (as hereinafter defined) for the applicable performance year and
whether the objectives of Covance's CEO have been satisfied for the performance
year in question (after giving effect to the adjustments specified in Paragraphs
8(a)(1) and (2), as applicable). Further, Covance's CEO shall assess the
performance of the Business Units and Operating Groups and Investment Units, if
any, and his executive management, including the Corporate Senior Vice
Presidents, compared to their applicable financial targets or objectives (in
each case after giving effect to the adjustments specified in Paragraphs 8(a)(1)
and (2), as applicable), for the performance year in question, and shall, at the
Committee's request, review such assessments with the Committee. Approved
minutes of the Committee shall satisfy the foregoing requirement. "Actual Bonus
Pool" means the amount of the actual Bonus Pool

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for the performance year in question after giving effect to the adjustments
specified in Paragraphs 8(a)(1) and (2), as applicable.

      (1) REQUIRED ADJUSTMENTS. The Bonus Pool and the related financial
target(s) shall be adjusted as of the end of the performance year in question to
give effect to the adjustment factors approved by the Committee in conjunction
with the establishment of the Bonus Pool and financial target(s) pursuant to
Paragraph 5.

      (2) DISCRETIONARY ADJUSTMENTS. In addition to the required adjustments
specified in Paragraph 8(a)(1), the CEO or the Committee, as applicable, may in
calculating the amount of the Bonus Pool as of the end of the performance year
in question and assessing whether the financial targets (including for the
Investment Units, if any) and objectives, in each case, have been satisfied, in
whole or in part, as applicable, or exceeded on a basis consistent with
circumstances existing when the Bonus Pool, such financial targets and
objectives, in each case, were established include or exclude, as applicable,
the effect on the Bonus Pool, the financial targets (including for the
Investment Units, if any) and objectives arising from any acquisition of the
stock or assets of any other person or entity, the divestiture of all or any of
the Company's businesses, restructurings, strategic expenditures by Covance
identified to the Covance Board of Directors as such, force majeure events,
material litigation, or any other unexpected or unforeseen extraordinary event
or occurrence during the performance year; PROVIDED, HOWEVER, that with respect
to Company employees who meet the definition of "covered employee" under Section
162(m) of the Internal Revenue Code, as amended from time to time and the
regulations thereunder the Committee shall not increase the amount of
compensation payable to such employee that would otherwise be paid based upon
attainment of the objectives in question.

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    (b) BONUS POOL ALLOCATIONS - CEO DISCRETIONARY AWARDS. The CEO shall have
the discretion and authority to allocate up to $500,000 of the Actual Bonus Pool
(such amount, as it may be increased by the Committee in its discretion for any
performance year based on the CEO's recommendation, being the "Discretionary
Bonus") to any individual who is not a Corporate Vice President or higher or to
any of the Business Units (including the Investment Units, if any) or Operating
Groups based on his sole and absolute judgment that such individual or entity
has made a significant contribution to the Company's success or for some other
important business reason. Such Discretionary Bonus shall not be paid until the
CEO has advised the Committee of his rationale for such awards.

    (c) BONUS POOL ALLOCATIONS - INVESTMENT UNITS. The CEO shall review the
Investment Units' financial results after the completion of the performance year
in question. The CEO may, but shall not be obligated to, score such performance
consistent with the methods described in Paragraph 8(f). In the event that such
Investment Units either do better or worse than the financial target specified
for such Investment Unit, then the CEO shall determine and approve the amount
from the Actual Bonus Pool, if any, that should be allocated to each such
Investment Unit, if any.

    (d) BONUS POOL ALLOCATIONS - COVANCE CORPORATE. Covance Corporate shall be
allocated a portion of the Actual Bonus Pool equal to the product of (1) a
fraction, (x) the numerator of which is the Actual Bonus Pool and (y) the
denominator of which is the 1x Bonus Pool (as hereinafter defined) and (2) the
1x Corporate Bonus Amount (as hereinafter defined). "1x Bonus Pool" means the
sum of the Employee Bonus Target Amounts for employees of the Company who are on
the Company's payroll as of the end of the performance year in question.

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      "1x Corporate Bonus Pool" means the sum of the Employee Bonus Target
Amounts for employees of Covance Corporate who are on the Company's payroll as
of the end of the performance year in question.

    (e) BONUS POOL ALLOCATIONS - CEO AND EXECUTIVE MANAGEMENT. Part I of
Appendix 1 sets forth the components of the variable compensation awards under
the Plan for any given performance year for the CEO and executive management
(including the Corporate Senior Vice Presidents). Part II of Appendix 1 sets
forth the method for computing such awards based on actual Company financial
performance.

    (f) BONUS POOL ALLOCATIONS - BUSINESS UNITS/OPERATING GROUPS. The amount of
the Actual Bonus Pool that shall be available for allocation to the Business
Units and Operating Groups for a given performance year shall be the difference
between (1) the Actual Bonus Pool for such performance year and (2) the sum of
the variable compensation awards determined pursuant to Paragraphs 7(b) - (e)
above (the foregoing sum being, the "Bonus Deductions"). Appendix 2 sets forth
the methodology for scoring a Business Unit's or Operating Group's performance
against its financial target(s) for the performance year in question. Appendix 3
sets forth the methodology for determining a Business Unit's or Operating
Group's allocable share of the Actual Bonus Pool (after giving effect to the
Bonus Deductions) for the performance year in question (such variable
compensation amount being for each such Business Unit or Operating Group, a
"Business Unit Actual Bonus Pool").

    (g) BONUS POOL ALLOCATIONS - INDIVIDUALS. Except in the case of the CEO and
the members of executive management (including Corporate Senior Vice
Presidents), actual variable compensation awards under the Plan to all employees
of the Company (including Covance Corporate) shall be determined by considering
the Company's Business Units', Operating Groups' and/or Investment Units', as
applicable, actual performance compared to the financial target for the year in
question (as adjusted

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pursuant to Paragraph 8(a)(1) and (2), as applicable), bonus payout percentage
represented by such results, their Employee Bonus Target Amounts, their bonus
payout percentages determined in accordance with such employees' performance
ratings and such other factors as may be appropriate; PROVIDED, HOWEVER, that
with respect to employees who are not Corporate Vice Presidents of the Company
or higher, the CEO shall have the authority to adjust, after consultation with
appropriate members of management, any individual's variable compensation award
under the Plan; PROVIDED, FURTHER, HOWEVER, that in no event shall the aggregate
amount of the variable compensation payments to a Business Unit, Operating Group
or Investment Unit for a given performance year exceed such entity's Business
Unit Actual Bonus Pool or the bonus pool for such Investment Unit (except for
any CEO discretionary awards pursuant to Paragraph 8(b)), nor shall the
aggregate of the variable compensation awards to all employees under the Plan
for a given performance year exceed the Actual Bonus Pool for the performance
year in question (except with respect to any CEO discretionary awards pursuant
to Paragraph 8(b)).

    (h) PRORATIONS. In furtherance of the second proviso of Paragraph 8(g), the
computation of any individual variable compensation award to any employee under
this Plan (including the CEO and executive management) shall be prorated for the
aggregate effect of individual performance assessments that, without giving
effect to such proration, would result in variable compensation awards that
would otherwise exceed the amount of the Actual Bonus Pool for the performance
year in question.

9. MAXIMUM VARIABLE COMPENSATION AWARD PAYOUT. In no event shall any individual
receive more than 200 percent of such individual's variable compensation target.

                                                                               9
<PAGE>

10. PAYMENT OF AWARDS. Variable compensation awards earned under the terms of
the Plan in excess of specified base levels may at the discretion of the
Committee, after consultation with Covance's management, be paid in cash, or in
stock options through the Employee Equity Participation Plan, or both. Payment
will be made as soon as practicable after the performance year in question, but
no later than each March 15 following the close of the applicable performance
year. Individuals may elect to defer payment of the variable compensation awards
in the event the Company has established a deferred compensation plan for
employees on the terms and conditions of such deferred compensation plan.

11. GOVERNING LAW; BINDING EFFECT. This plan shall be governed by and construed
in accordance with the laws of the State of New Jersey (without regard to the
conflict of law provisions thereof) and all questions concerning the validity
and construction thereof shall be governed in accordance with the laws of said
state; PROVIDED, HOWEVER, that all matters of corporate governance and other
corporate matters concerning Delaware corporations shall be governed by the
Delaware General Corporation Law. Except as otherwise expressly provided herein,
this Plan shall be binding upon and inure to the benefit of the parties hereto,
their legal representatives, successors and assigns.

12. TERMINATION OF EMPLOYMENT. Participation in the Plan does not create a
contract of employment, nor grant any employee of the Company the right to be
retained in the service of, or otherwise employed by, the Company. Individuals
will not receive a variable compensation award under this Plan for the
performance year in which their employment terminates for any reason or no
reason or if they are terminated for any reason or no reason prior to the date
the variable compensation is actually paid for the

                                                                              10
<PAGE>

performance year in question, except as otherwise provided in Paragraph 2
hereof. Without limiting the foregoing or Paragraph 2 hereof, any individual
whose employment is terminated for wrongdoing, including, but not limited to, a
violation of the Company's Business Integrity Program, including the Code of
Conduct, will forfeit all rights to payment under this Plan.

13. EFFECTIVE DATE. The Plan will take effect as of January 1, 2000 and
supersedes in its entirety the Covance Way Covance Inc. Variable Compensation
Plan approved on February 25, 1999 (and effective January 1, 1999), the Covance
Way Covance Inc. Variable Compensation Plan, as amended, effective January 1,
1998, the Covance Inc. Variable Compensation Plan, as amended, and effective
January 1, 1997, the Covance Inc. General Employee Variable Compensation Plan,
as amended, and effective January 1, 1997 and the Covance Biotechnology Services
Inc. Variable Compensation Plan, as amended, and effective January 1, 1997.

14. AMENDMENT, SUSPENSION, OR TERMINATION. The Board or Committee may, at any
time, suspend, terminate, waive or amend the Plan (or provisions hereof, as
applicable), in such respects as the Board or Committee deems to be in the best
interest of the Company. No amendment will adversely affect any right of any
grantee, or his successors in interest, to keep any variable compensation award
actually made hereunder before the effective date of the amendment. Plan
deferrals, if any, in effect at the Plan's termination remain in effect
according to their original terms.

                                                                              11
<PAGE>

                                   APPENDIX 1

                    COMPONENTS, ADJUSTMENTS AND COMPUTATIONS

                             OF EXECUTIVE MANAGEMENT

                          VARIABLE COMPENSATION AWARDS

Part I.  COMPONENTS

         A.   CEO

              The CEO's variable compensation award is based on his individual
              performance rating (which is based in part on the satisfaction of
              objectives) and the satisfaction of targeted Covance financial
              metrics for the applicable performance year such as EPS or pre-tax
              and pre-bonus income, as approved by the Committee.

         B.   GLC STAFF EXECUTIVES

         o    50% of variable compensation award is based on executive's
              performance rating (which is based in part on satisfaction of
              specified individual objectives).

         o    50% of variable compensation awards is based on satisfaction of
              targeted Covance financial targets as specified for the applicable
              performance year such as EPS or pre-tax and pre-bonus income.

         C.   GLC OPERATIONS EXECUTIVES

         o    25% of the variable compensation award is based on executive's
              performance rating (which is based in part on satisfaction of
              specified individual objectives).

         o    25% of the variable compensation awarded is based on executive's
              Business Unit's satisfaction of his Business Unit financial target
              for the performance year in question such as pre-tax and pre-bonus
              income or pre-bonus operating margin.

         o    50% of the variable compensation award is based on satisfaction of
              targeted Covance financial targets as specified for the applicable
              performance year such as EPS or pre-tax and pre-bonus income.

                                                                              12
<PAGE>

                               APPENDIX 1 (CONT'D)

Part II.  METHODOLOGY

          A.   CEO

          The CEO shall be awarded a variable compensation amount under the Plan
          equal to the product of (x) such executive's Employee Bonus Target
          Amount, (y) such executive's bonus payout percentage, determined in
          accordance with such executive's performance rating for the
          performance year in question and (z) a fraction (i) the numerator of
          which is the Actual Bonus Pool earned for the performance year in
          question and (ii) the denominator of which is the 1x Bonus Pool, as
          adjusted, for the performance year in question.

          B.   GLC OPERATIONS EXECUTIVES

          GLC Operations Executives shall be awarded a variable compensation
          amount under the Plan equal to the sum of (1) an amount equal to the
          product of (w) .5 and (x) executive's Employee Bonus Target Amount and
          (y) a fraction (i) the numerator of which is the actual Bonus Pool
          earned for the performance year in question and (ii) the denominator
          of which is the 1x Bonus Pool, as adjusted, for the performance year
          in question, (2) an amount equal to the product of (w) .25 and (x)
          executive's Employee Bonus Target Amount and (y) a fraction (i) the
          numerator of which is the Business Unit's Actual Bonus Pool earned for
          the executive's Operating Group or Business Unit, as applicable, for
          the performance year in question and (ii) the denominator of which is
          the 1x Bonus Pool, as adjusted, for such Operating Group or Business
          Unit and (3) an amount equal to the product of (w) .25 and (x) such
          executive's Employee Bonus Target Amount and (y) such executive's
          bonus payout percentage, determined in accordance with such
          executive's performance rating for the performance year in question.

          C.   GLC STAFF

          GLC Staff Executives shall be awarded a variable compensation amount
          under the Plan equal to the sum of (1) an amount equal to the product
          of (w).5 and (x) such executive's Employee Bonus Target Amount and (y)
          such executive's bonus payout percentage, determined in accordance
          with such executive's performance rating for the performance year in
          question and (2) an amount equal to the product of (x) .5 and (y) such
          executive's Employee Bonus Target Amount and (z) a fraction (i) the
          numerator of which is the Actual Bonus Pool earned for the performance
          year in question and (ii) the denominator of which is the 1x Bonus
          Pool, as adjusted, for the performance year in question.

                                                                              13
<PAGE>

                                   APPENDIX 2

                               BONUS POOL SCORING
                                   METHODOLOGY

      METHODOLOGY: The CEO shall review and determine a Business Unit's or
Operating Group's (or Investment Unit's, as applicable) performance against its
financial targets after the completion of the performance year in question as
specified below:

                        FINANCIAL PERFORMANCE POINT RANGE

                              Minimum           Target          Maximum
                             Financial        Financial        Financial
                            Performance      Performance      Performance
                            -----------      -----------      -----------

      CATEGORY

      Pre-Bonus                       -----------------------
      Operating Margin(1)        70              100              120    Points

------------------------
(1) A Business Unit or Operating Group scores the maximum of 120 points if it
    achieves 110% of its pre-bonus operating margin target (such entity gets 2
    additional points for each 1% over its pre-bonus operating margin target),
    and a minimum of 70 points by achieving 70% or less of its
    pre-bonus-operating margin target (i.e., such entity loses 1 point for each
    1% deficiency to its pre-bonus operating margin target).

                                                                              14
<PAGE>

                                   APPENDIX 3

              INDIVIDUAL EMPLOYEE PAYOUT METHODOLOGY

METHODOLOGY

Any employee of the Company, except as specified in Paragraph 8(g) of the Plan,
will be paid a variable compensation amount under the Plan equal to the product
(1) a fraction, (a) the numerator of which is the Employee Theoretical Bonus
Amount (as hereinafter defined) and (b) the denominator of which is the sum of
the Business Unit's or Operating Group's Employee Theoretical Bonus Amounts and
(2) the Business Unit Actual Bonus Pool.

"EMPLOYEE THEORETICAL BONUS AMOUNT" means the product of the Employee Bonus
Target Amount and the individual's bonus payout percentage, determined in
accordance with the individual's performance rating as specified under the Plan.

                                                                              15

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