Document:

<PAGE>

                                                                    EXHIBIT 4.11

                               DRAXIS HEALTH INC.
                          EMPLOYEE STOCK OWNERSHIP PLAN
                              AMENDED AND RESTATED
                           EFFECTIVE DECEMBER 1, 1998

1.       THE PLAN

         The Draxis Health Inc. Stock Purchase and Bonus Plan is amended and
restated effective December 1, 1998 and is after such date referred to as the
Draxis Health Inc. Employee Stock Ownership Plan (the "Plan").

2.       PURPOSE

         The Draxis Health Inc. Stock Ownership Plan (the "Plan") is intended to
develop the interest and incentive of employees including permanent part-time
employees (collectively, the "Employees") of Draxis Health Inc. (the "Company")
and its subsidiaries in their day-to-day operations in the growth and
development of the Company and its subsidiaries by giving the Employees an
opportunity to purchase common shares of the Company ("Common Shares").

3.       ELIGIBILITY

         All Employees of the Company and its subsidiaries (collectively the
"Employer") are eligible to purchase Common Shares under the terms of the Plan.

4.       COMMON SHARES TO BE OFFERED

         The Common Shares to be made available for the purposes of the Plan
shall be purchased for the purpose of selling such shares to an Employee by
Montreal Trust Company of Canada (the "Trustee") in the open market on the
Toronto and Nasdaq Stock Exchanges and held pursuant to the terms and
conditions of this Plan and the terms of the trust agreement between the
Company and the Trustee dated ______________ and annexed hereto as Exhibit A.

5.       RIGHT TO PURCHASE COMMON SHARES

         All Employees shall be participants ("Participants") in the Plan unless
prior to December 31 of each Year, an Employee advises his or her Employer that
he or she does not wish to be a participant in the Plan for the calendar year
then ending. Each Participant shall complete a stock purchase form (in the form
annexed hereto as Schedule A-1 for non-U.S. Residents and in the form annexed
hereto as Schedule A-2 for U.S. residents).

6.       TERMS AND CONDITIONS OF THE PURCHASE PLAN

         The purchase of Common Shares by Participants from the Trustee pursuant
to the Plan shall be subject to the following terms and conditions:

<PAGE>

                                      -2-

(a)      PURCHASE PRICE. The purchase price for each Common Share to be
         purchased by a Participant shall, notwithstanding the actual purchase
         price, be deemed to be the last reported sale price (the "Purchase
         Price") of the Common Shares on The Toronto Stock Exchange on December
         31 of the Year just ended or, if such day is not a business day, then
         the last business day in December.

(b)      TRANSFERABILITY. Any rights granted to a Participant under this Plan
         may not be transferred other than by will or the laws of succession on
         intestacy in the jurisdiction in which the Participant had his last
         fixed place of abode and will be exercisable during a Participant's
         lifetime only by the Participant.

(c)      NUMBER OF SHARES A PARTICIPANT MAY PURCHASE. The Trustee shall purchase
         for each Participant that number of Common Shares (the "Employee
         Shares") that is equal to the quotient obtained when 7% of a
         Participant's cash compensation, including bonuses, from the Employer
         with respect to the immediately preceding Year (the "Reference Year")
         is divided by the Purchase Price.

(d)      ADJUSTMENT IN NUMBER OF COMMON SHARES. The number of Employee Shares
         that a Participant may purchase under the Plan, or the Purchase Price,
         shall be appropriately adjusted for any change in the Common Shares, or
         in the number of Common Shares outstanding, by reason of any
         recapitalization, reorganization, merger consolidation, split or any
         similar change affecting the Common Shares, except that any fraction of
         a Common Share resulting from any such adjustment will be eliminated.

(e)      PAYMENT AND RELEASE OF SHARES.

         (i)      Each Participant shall satisfy the entire amount of the
                  Purchase Price for the Employee Shares to be purchased (the
                  "Purchased Shares") by him pursuant to this Plan by issuing to
                  the Trustee a non-interest bearing promissory note (the
                  "Promissory Note") in the form annexed hereto as Schedule B,
                  payable in five equal instalments (the "Instalment(s)") on the
                  first, second, third, fourth and fifth anniversary of the
                  Purchase Date (the "Instalment Date(s)"). The Promissory Note
                  shall be in the form attached hereto as Schedule B. The
                  Trustee shall hold the Purchased Shares as security for the
                  payment of the Promissory Note.

         (ii)     On each Instalment Date and subject as hereinafter provided,
                  the amounts paid to the Trustee pursuant to the Participant's
                  direction described in Section 8 hereof shall be accepted by
                  the Trustee in satisfaction of the Participant's obligation to
                  pay the amount due on an Instalment Date pursuant to the terms
                  of the Promissory Note. Provided, however, no

<PAGE>

                                      -3-

                  Purchased Shares shall be released unless and until the
                  Company has advised the Trustee that the requisite employee
                  source withholdings have been provided by the Participant.

         (iii)    Subject to payment in accordance with paragraph 6(e)(ii)
                  hereof, Common Share certificates representing the Purchased
                  Shares owned by a Participant and the Share Earnings described
                  in paragraph 7(a) hereof and held by the Trustee as security
                  for payment of the Promissory Note, shall be released to the
                  Participant by the Trustee and registered in the name of the
                  Participant, or as he or she may direct as follows:

                  A.       one-fifth of the Purchased Shares upon full payment
                           of the first Instalment on the first Instalment Date;

                  B.       one-fifth of the Purchased Shares upon full payment
                           of the second Instalment on the Second Instalment
                           Date; and

                  C.       one-fifth of the Purchased Shares upon full payment
                           of the third Instalment on the Third Instalment Date;

                  D.       one-fifth of the Purchased Shares upon full payment
                           of the fourth Instalment on the Fourth Instalment
                           Date;

                  E.       one-fifth of the Purchased Shares upon full payment
                           of the fifth Instalment on the Fifth Instalment Date;

                  F.       all of the Share Earnings on the Fifth Instalment
                           Date;

         (iv)     prior to the release of any certificates pursuant to paragraph
                  6(e)(iii) above, the Participant shall provide to the Trustee
                  a certificate (in the form attached hereto as Schedule D)
                  stating that the representations made in Schedule A are true
                  and correct as of the date of release of the certificate. If
                  such certificate cannot be provided, the Trustee shall hold
                  the Purchased Shares to be released to the Participant until
                  such time as a certificate can be provided, unless such
                  Purchased Shares are registered under the SECURITIES ACT of
                  1933 of the United States, as amended, or an exemption from
                  registration requirements is available thereunder, based upon
                  an opinion of the Company's counsel.

(f)      RIGHTS IN THE EVENT OF TERMINATION OF EMPLOYMENT OR ENGAGEMENT OF A
         PARTICIPANT FOR ANY REASON.

         (i)      Upon termination ("Termination") of the employment of a
                  Participant for

<PAGE>

                                      -4-

                  any reason including death, the Participant's right to
                  purchase additional Common Shares pursuant to the Plan shall
                  be immediately canceled and be of no further effect.

         (ii)     Upon a Participant's termination of employment due to death,
                  permanent disability or resignation AFTER age 60 Participants
                  will be entitled to continue to receive the release of
                  Employee Shares in accordance with paragraph 6(e) and Section
                  8 hereof and the terms thereof shall apply mutatis mutandis.

         (iii)    Upon a Participant's termination of employment due to death,
                  permanent disability or resignation prior to age 60, any
                  amount owing in respect of the Purchase Price for the Employee
                  Shares shall be immediately due and payable and any such
                  obligation of a Participant may be satisfied by surrendering
                  the Employee Shares held by the Trustee as security by the
                  Trustee for any unpaid balance of the Purchase Price for the
                  Purchased Shares. In such an event an amount will be included
                  in a Participant's income for income tax purposes equal to the
                  amount, if any, by which the amount payable under the
                  Promissory Note outstanding at the date of such termination of
                  employment exceeds the value of the particular Employee Shares
                  at that time.

7.       COMMON SHARES HELD BY TRUSTEE PRIOR TO PURCHASE BY OR RELEASE TO
         PARTICIPANTS

         Until the Employee Shares held by the Trustee as security in accordance
with paragraph 6(e) are released to the Participant pursuant to the Plan:

         (a)      the Trustee shall, in respect of such Employee Shares hold
                  such Shares and any dividends, income or distributions in
                  respect thereof and any substitutions therefor and any
                  interest thereon (the "Share Earnings"); and

         (b)      the Trustee, subject to Section 9 of the Plan, shall exercise
                  all voting rights and other rights attaching to such Employee
                  Shares, in accordance with the instructions of a Participant
                  for whom such Shares are held.

8.       CASH BONUS OR FEE

         Except where circumstances described in paragraphs 9(a) and 9(e) have
occurred, on each Instalment Date, the Company shall pay to a Participant a cash
bonus or fee in respect of past services, the gross amount of which shall be
equal to the amount payable under the Promissory Note to the Trustee on the
Instalment Date. Each Participant shall execute a direction to the Company in
the form attached hereto as Schedule C directing it to pay over the amount of
such cash bonus to the Trustee in full satisfaction of Participant's obligation
to pay the amount due

<PAGE>

                                      -5-

on the Instalment pursuant to the terms of the Promissory Note.

9.       TAKEOVER BID

         (a)      If:

                  (i)      an offeror makes an offer to purchase 50% or more of
                           the outstanding Common Shares to all or substantially
                           all holders of the Common Shares and the board of
                           directors of the Company recommends acceptance of
                           such offer to the shareholders of the Company, or

                  (ii)     an insider of the Company makes an offer to purchase
                           Common Shares to all or substantially all holders of
                           the Common Shares;

                  (iii)    or an offeror makes an offer, by way of merger,
                           amalgamation, reorganization, consolidation, exchange
                           or otherwise, the result of which would be the
                           acquisition by such offeror, directly or indirectly,
                           of 50% or more of the outstanding equity securities
                           of the Company or a successor entity;

                  (iv)     an offeror makes an offer to purchase substantially
                           all of the assets of the Company; or

                  (v)      the Company shall consolidate or merge with or into,
                           amalgamate with, or enter into a statutory
                           arrangement or business combination with, any other
                           individual, partnership, association, trust,
                           unincorporated organization corporation (other than a
                           corporation controlled directly or indirectly by the
                           Company) and, in connection therewith, all or part of
                           the outstanding shares of the Company which have
                           voting rights attached thereto shall be changed in
                           any way, reclassified or converted into, exchanged or
                           otherwise acquired for shares or other securities of
                           the Company or any other individual, partnership,
                           association, trust, unincorporated organization or
                           corporation or for cash or any other property and
                           control of the Company is thereby materially
                           affected;

                  and the board of directors of the Company recommends
                  acceptance of such offer, merger, consolidation or the like
                  (the "Proposed Transaction") to the shareholders of the
                  Company:

                  upon a Proposed Transaction offer described in (i), (ii),
                  (iii) or (v):

                  All Employee Shares held by the Trust will be tendered or
                  voted in favour of the Proposed Transaction; and in the event
                  the Proposed Transaction is successful,

<PAGE>

                                      -6-

                  the Company will declare a cash bonus for each Participant in
                  the amount of all outstanding Promissory Notes payable. The
                  full pre-tax portion of the bonus will be paid to the Trust in
                  satisfaction of the interest-free loans. The consideration
                  pursuant to the transaction will be released to Participants
                  following payment by them of the requisite withholdings on the
                  amount of such bonus.

                  upon a Proposed Transaction offer described in (iv):

                  All Plan Shares held by the Trust will be voted in favour of
                  the Proposed Transaction; and in the event the Proposed
                  Transaction is successful, the Company will declare a cash
                  bonus for each Participant in the amount of all outstanding
                  promissory notes payable. The full pre-tax portion of the
                  bonus will be paid to the Trust in satisfaction of the
                  interest-free loans. All Plan Shares will be released to
                  Participants following payment by them of the requisite
                  withholdings on the amount of such bonus.

         (b)      In the event the Board of Directors does not recommend
                  acceptance of a Proposed Transaction offer, the Plan Shares
                  will be voted in accordance with the Board recommendation.
                  However, in the event a Proposed Transaction takes place, the
                  consequences described above relating to a recommended
                  Proposed Transaction shall apply. In the event a Proposed
                  Transaction does not take place the provisions of the Plan as
                  they existed prior to receiving a Proposed Transaction offer
                  will apply;

         (c)      any of the Chairman or the President, on behalf of the
                  Company, may give the Trustee written notice (the "Notice")
                  stating that

                  (i)      the board of directors of the Company has or has not
                           recommended acceptance of Proposed Transaction offer
                           to shareholders of the Company;

                  (ii)     the provisions of this Section 9, where applicable,
                           are operative;

                  (iii)    the Trustee should either tender or not tender
                           pursuant to the Proposed Transaction offer all
                           Employee Shares held by the Trustee pursuant to the
                           provisions of the Plan;

         (d)      if an offeror under a Proposed Transaction described in (i),
                  (ii) or (iii) does not take up and pay for the Employee Shares
                  tendered pursuant to the offer as described therein and as a
                  result such Shares are returned to the Trustee then the
                  Employee Shares shall remain in the Plan as security for
                  payment of the Promissory Notes and the rights of the
                  Participants, other than the Insiders, under

<PAGE>

                                      -7-

                  the Plan shall continue as if this Section 7 had not come
                  into effect.

10.      SALE OF SHARES - COMMISSIONS

         Commissions on the purchase of Common Shares by the Trustee for the
purposes of the Plan will be borne and paid for by the Company. Commissions with
respect to any sale of Common Shares shall be borne and paid for by the Vendor
of such shares.

11.      ADMINISTRATION

         (a)      This Plan shall be administered by the Chairman of the Company
                  who shall have full power and authority to interpret and
                  construe the terms and conditions of the Plan and the terms
                  and conditions of any rights granted under the Plan. Any
                  determination by the Chairman shall be final and conclusive
                  unless otherwise determined by the Board of Directors of the
                  Company, and in any such event such determination of the Board
                  of Directors shall be final and conclusive.

         (b)      Neither the Trustee, the Board of Directors, nor the Chairman
                  of the Company, nor any member of the Board of Directors shall
                  be liable for any act, omission, interpretation, construction
                  or determination made in good faith in connection with the
                  Plan, or any rights granted under the Plan. The Trustee, the
                  members of the Board of Directors and the Chairman, and each
                  of them, shall be indemnified and saved harmless by the
                  Company from and against any and all claims, losses, damages,
                  expenses and liabilities to which they may be subjected by
                  reason of any act reasonably taken or omitted in good faith
                  with respect to the Plan or any rights granted under the Plan,
                  including all expenses reasonably incurred in their defense in
                  case the Company fails to provide such defense.

         (c)      Any and all costs of administration of the Plan shall be borne
                  and paid for by the Company.

12.      GOVERNING LAW

         This Plan shall be governed by and construed in accordance with the
laws of the Province of Ontario and the laws of Canada.

13.      APPLICATION

         The terms and conditions of this Plan effective December 1, 1998 will
apply to all shares held by the Trustee pursuant to the terms of the Plan
whether acquired prior to or after November 30, 1998. Provided however that the
terms of paragraph 4(f) of the Draxis Health Inc. Stock Purchase and Bonus Plan
restated 1997 shall apply to those Common Shares acquired prior to November 30,
1998 and held by the Trustee.

<PAGE>

14.      EFFECTIVE DATE

         All provisions set forth herein have effect from December 1, 1998.

15.      AMENDMENT AND DISCONTINUANCE

         (a)      The Board of Directors of the Company shall have the right to
                  amend, modify or discontinue this Plan or any rights granted
                  under this Plan at any time without notice.

         (b)      Upon discontinuance of the Plan any assets remaining in the
                  Plan shall be disposed of as follows:

                  (i)      all Employee Shares shall be released to the
                           Participants against payment therefor; and

                  (ii)     any amounts remaining in the Plan shall be used
                           firstly to repay all advances by the Company to the
                           Trustee.

         If amounts are insufficient to repay the entire amount of the advances
         by the Company to the Trustee, the Company shall pay to the Trustee
         the amount of the shortfall as a contribution to the Plan, such that
         all advances made by the Company to the Trustee can be repaid. Any
         surplus remaining after repayment of all of the advances by the
         Company shall be paid to the Company.

<PAGE>

                                  SCHEDULE A-1

                               DRAXIS HEALTH INC.

                              STOCK OWNERSHIP PLAN

TO:               Draxis Health Inc.

AND TO:           Montreal Trust Company of Canada
                  Trustee of the Draxis Health Inc.
                  Stock Ownership Plan

A.       APPLICATION

         Words capitalized and not otherwise defined herein shall have the
meanings ascribed thereto in the Plan or the Trust Agreement.

         I, the undersigned, acknowledge that I have been advised by Draxis
Health Inc. (the "Company") that I am eligible to participate in the Draxis
Health Inc. Stock Ownership Plan (the "Plan") and that I have received a copy of
the Plan and accompanying Trust Agreement.

         I irrevocably acknowledge and accept the terms and conditions of the
Plan and hereby elect to participate in the Plan.

         I hereby apply to purchase at the Purchase Price per Common Share
________________________ Common Shares (the "Elected Number") (not to exceed the
amount that results when 7% of the Participant's cash compensation or fees
during the Reference Year from the Company is divided by the Purchase Price).

         I enclose a Promissory Note in the amount of $___________ in favour of
the Trustee in payment of the Elected Number of Common Shares (the "Elected
Number").

Name:                                       Employee No.:
     --------------------------------                    -----------------------
(please print)                              Social Insurance No.
                                                                ----------------

Address:
        -----------------------------

        -----------------------------

        -----------------------------

<PAGE>

                                      -2-

Dated this _______ day of _____________________, 19___.

-------------------------------------
Signature

-------------------------------------
(Print Name)

Draxis Health Inc. hereby acknowledges and confirms the foregoing.

DATED this _______ day of _____________________, 19___.

                                        DRAXIS HEALTH INC.

                                        By:
                                           -------------------------------------

<PAGE>

                                   SCHEDULE B

                                 PROMISSORY NOTE

PRINCIPAL AMOUNT                                  Toronto, Ontario
$____________                                ________________________, 19___

         FOR VALUE RECEIVED, I, the undersigned (the "Payor"), hereby
acknowledge myself indebted to and promise to pay to Montreal Trust Company
of Canada (the "Payee"), on demand, the principal sum of $        in lawful
money of Canada in five equal instalments on the first, second, third, fourth
and fifth anniversaries of the date of this promissory note (the "Note").

         This Note is given pursuant to the terms and conditions of the Draxis
Health Inc. Stock Ownership Plan in which the Payor is a participant.

         Upon the demand of the Payee, the entire unpaid balance of this Note
shall become due and payable without notice, protest or other act and the Payor
hereby waives presentment for payment.

         All sums which are payable hereunder shall be payable at 151 Front
Street West, 8th Floor, Toronto, Ontario M5J 2M1 or such other place as the
Payee may direct in writing.

         This Note shall be governed by the laws of the Province of Ontario, may
be amended only in writing, shall bind the Payor, shall benefit the Payee, its
successors and assigns and is not subject to any representation, right,
agreement or condition (oral, written, expressed, implied, statutory, collateral
or other) other than as expressed herein in writing. No waiver of any right
expressed herein shall bind the Payee unless expressly stated in writing signed
by the Payee and such requirement shall not be waived by either the Payor or the
Payee.

         IN WITNESS WHEREOF the Payor has executed this Note.

---------------------------------  ------------------------------
Witness                                 Payor

---------------------------------  ------------------------------
(Print Name)                            (Print Name)

<PAGE>

                                   SCHEDULE C

                                    DIRECTION

TO:               Draxis Health Inc.

         Reference is made to the Draxis Health Inc. Stock Ownership Plan (the
"Plan"). Words capitalized and not otherwise defined herein shall have the
meanings ascribed thereto in the Plan.

         The undersigned hereby directs the Company to pay over to the Trustee
the amount of any cash bonus or fee contemplated under the Plan (the "Bonus")
paid by an Employer to the undersigned in respect of past services. The gross
amount of the Bonus shall be equal to the amount payable by the undersigned
under the Promissory Note to the Trustee on the Instalment Date.

         DATED this _______ day of _____________________, 19___.

                                             Signature

                                             -----------------------------------
                                             (Print Name)

                                             Address:
                                                     ---------------------------

                                             -----------------------------------

                                             -----------------------------------

                                             Employee No.
                                                         -----------------------

                                             Social Insurance No.:

                                             -----------------------------------

<PAGE>

                                   SCHEDULE D

                               DRAXIS HEALTH INC.

                              STOCK OWNERSHIP PLAN

TO:               Montreal Trust Company of Canada
                  Trustee of the Draxis Health Inc.
                  Stock Ownership Plan

         Words capitalized and not otherwise defined herein shall have the
meanings ascribed thereto in the Plan or the Trust Agreement.

         I, the undersigned, hereby certify that the representations and
warranties made in the Stock Purchase Form signed by me on          are true
and correct on the date hereof.

         DATED this _______ day of _____________________, 19___.

                                             -----------------------------------
                                             Signature

                                             -----------------------------------
                                             (Print Name)

<PAGE>

                                    EXHIBIT A

THIS TRUST AGREEMENT is entered into effective as of the ______ day of_________,
19____.

B E T W E E N:                      DRAXIS HEALTH INC., a company duly
                                    incorporated under the laws of Canada,
                                    (hereinafter referred to as the "Company")

                                               OF THE FIRST PART

                                    - A N D -

                                    ROYAL TRUST CORPORATION OF CANADA, a trust
                                    company incorporated under the laws of
                                    Canada, (hereinafter referred to as the
                                    "Trustee")

                                               OF THE SECOND PART

WHEREAS Deprenyl Research Limited (the "Former Company") established an
Employees Stock Purchase Plan, the Stock Purchase and Bonus Plan (the "Prior
Plan") for the purpose of providing benefits to certain of its employees and of
the employees of any designated subsidiary or affiliated corporation;

AND WHEREAS the Prior Plan provided for the establishment of a trust fund to be
maintained in order to provide for the benefits described in the Plan;

AND WHEREAS the Former Company established such a trust fund and appointed the
Montreal Trust Company of Canada to be the trustee of such trust fund under a
trust agreement dated December 1, 1990;

AND WHEREAS the Former Company changed its name to Draxis Health Inc. (the
"Company");

AND WHEREAS the Company has amended and restated the Prior Plan, wherein,
amongst other amendments the name has been changed to the Draxis Health Inc.
Employee Stock Ownership Plan (the "Plan", as hereinafter defined) and attached
hereto as Exhibit "A";

AND WHEREAS Royal Trust Corporation of Canada, pursuant to an Agreement of
Purchase and Sale, dated February 19, 1997, purchased Montreal Trust Company of
Canada's right and title to and interest in their Pension Trust and Custody
Business;

AND WHEREAS the Company now wishes to appoint Royal Trust Corporation of Canada
as trustee of the Plan and to amend and restate the trust agreement in its
entirety;

AND WHEREAS the Company shall be responsible for all matters relating to the
interpretation and administration of the Plan;

<PAGE>

                                       2

NOW THEREFORE the Company and the Trustee agree as follows:

                                    ARTICLE I
                                   DEFINITIONS

The following terms set out herein with initial capital letters shall have the
meanings assigned below:

BENEFICIARIES:             shall mean any person entitled to receive benefits or
                           payments in accordance with the terms of the Plan and
                           may include the Company.

DIRECTION:                 shall mean all directions, notices, requests,
                           instructions and objections given in accordance with
                           Article VI by those individuals so authorized to make
                           such representations and to issue such directions
                           under the terms of this Agreement or as provided in
                           writing.

INVESTMENT MANAGER:        shall mean any person appointed by the Company to
                           manage the investment of the whole or any portion of
                           the Trust Fund, who may be, but shall not be limited
                           to, an employee of the Company, or a subsidiary
                           thereof, or a board or committee, the members of
                           which consist of one or more employees, and is
                           responsible for directing the Trustee with respect to
                           all investments of the Trust Fund.

PLAN:                      shall mean the employee's stock purchase plan which
                           is known and designated as the Draxis Health Inc.
                           Employee Stock Ownership Plan and has been
                           established by the Company for the purpose of
                           providing benefits to certain of its employees and
                           employees of any subsidiary or affiliated
                           corporation, as amended from time to time.

RELATED PARTY:             shall mean the Trustee or any individual, firm,
                           partnership, association, trust, corporation or other
                           person which is a restricted party of the Trustee
                           within the meaning of the Loan and Trust Corporations
                           Act, 1987 (Ontario) or in which the Trustee is
                           directly or indirectly interested.

TRUST FUND:                shall mean all money and assets paid and delivered to
                           the Trustee, and acceptable to the Trustee, together
                           with any earnings, profits and increments thereon and
                           all assets from time to time substituted therefor,
                           less authorized payments therefrom.

<PAGE>

                                       3

                                   ARTICLE II
                      ESTABLISHMENT AND ACCEPTANCE OF TRUST

2.1      ESTABLISHMENT OF TRUST FUND

         All assets paid or delivered or caused to be paid and delivered by the
         Company from time to time to the Trustee and acceptable to the Trustee,
         together with any earnings, profits and increments thereon and assets
         from time to time substituted therefor, shall constitute the Trust Fund
         established in conjunction with the Plan and shall be held by the
         Trustee in trust and applied by the Trustee in the manner and for the
         purposes provided in this Trust Agreement.

         Money paid or property distributed by the Trustee in accordance with
         the provisions of this Trust Agreement shall cease to form part of the
         Trust Fund upon the Trustee taking such action as is normally required
         for making payments or delivery of property.

2.2      APPOINTMENT AND ACCEPTANCE OF TRUST

         The Company hereby appoints the Trustee as trustee of, and the Trustee
         hereby accepts, the trust created by this Trust Agreement, and the
         Trustee agrees to hold, invest and administer the Trust Fund subject to
         the terms and conditions of this Trust Agreement.

2.3      BENEFICIARIES

         No Beneficiary shall have any claim against the Trustee or bring an
         action against the Trust Fund or require an accounting of the Trust
         Fund except by or through the Company. In addition, any claim for or
         right to any benefit or payment of any amount shall be governed solely
         by the terms of the Plan and applicable legislation.

2.4      FISCAL YEAR

         The fiscal year of the Trust Fund shall end on the 31st day of
         December of each year.

                                   ARTICLE III
                             CONCERNING THE TRUSTEE

3.1      RESPONSIBILITIES OF THE TRUSTEE

         The Trustee shall:

         3.1.1    Hold title to all assets comprising the Trust Fund, for the
                  account of the Trust Fund;

         3.1.2    Keep the Trust Fund distinct from its own assets and those of
                  any other person in the accounts and records kept by the
                  Trustee and should the assets of the Trust Fund for any
                  reason become mixed with the assets of the

<PAGE>

                                       4

                  Trustee, the entire resulting mixed fund shall be deemed to be
                  held by the Trustee in trust hereunder to the extent necessary
                  to satisfy the Trust Fund's claim on such mixed fund;

         3.1.3    From time to time, make all distributions, disbursements and
                  payments out of the Trust Fund to such persons (including the
                  Company) on Directions;

         3.1.4    The Trustee will notify the Company upon the receipt by it of
                  any assignment or attempted assignment or notice thereof or of
                  any involuntary assignment, seizure, garnishment or any
                  process of law or execution or notice thereof in respect of
                  any benefit payable out of the Trust Fund.

         3.1.5    Take all reasonable steps to collect and receive all income,
                  principal, dividends and other payments and distributions when
                  due in respect of any assets of the Trust Fund and promptly
                  credit all such receipts received by it to the Trust Fund;

         3.1.6    Act in accordance with the Directions with respect to the
                  exercise of its powers including, without limitation, the
                  acquisition or disposition of any asset and the exercise of
                  any voting rights, warrants, options or conversion or exchange
                  privileges, or other rights attached to or available in
                  connection with any assets at any time forming part of the
                  Trust Fund or with respect to any other matter pursuant to
                  this Trust Agreement;

         3.1.7    Receive all contributions under the Plan or other transfers of
                  assets to the Trust Fund made by the Company or any other
                  person or persons pursuant to the terms of the Plan and this
                  Trust Agreement;

         3.1.8    Keep accurate and detailed accounts and records of all assets
                  and transactions with respect to the Trust Fund which shall be
                  open to inspection and audit at all reasonable times by any
                  person duly authorized by the Company;

         3.1.9    Keep, or cause to be kept, accurate and detailed accounts and
                  records of all contribution and forfeiture amounts, if any,
                  credited to each Beneficiary under the Plan, the investments
                  acquired therewith, the earnings and profits thereon and any
                  withdrawals therefrom;

         3.1.10   Provide to the Company, within ninety (90) days following the
                  last day of the fiscal year of the Trust Fund, or such other
                  accounting period as may be agreed upon by the Company and the
                  Trustee, or following the resignation or the removal of the
                  Trustee, a statement of account showing all assets,
                  transactions, receipts and disbursements during the accounting
                  period in such form as, may from time to time, be agreed by
                  the Company and the Trustee;

<PAGE>

                                       5

         3.1.11   Provide, or cause to be provided, to each Beneficiary, at
                  the end of such accounting periods and in such form as may be
                  agreed upon from time to time by the Company and the Trustee,
                  a statement of the account of such Beneficiary showing the
                  contributions and forfeitures credited to the Beneficiary, the
                  investments acquired therewith, the earnings and profits
                  thereon and any withdrawals therefrom. One such statement
                  shall be provided as at December 31 in each year, and

         3.1.12   Calculate any applicable taxes with respect to the Trust Fund,
                  file any required tax or information returns or other filings,
                  withhold from any payments from the Trust Fund and remit from
                  the Trust Fund all taxes and other assessments and provide to
                  each Beneficiary an annual income tax information slip, all as
                  may be required of the Trustee under the Income Tax Act
                  (Canada).

3.2      STANDARD OF CARE

         In exercising its powers and performing its responsibilities hereunder,
         the Trustee shall act honestly and in good faith and shall exercise the
         same degree of care which it gives to its own assets of a similar kind.

3.3      LIMITATION OF LIABILITY

         3.3.1    The Trustee shall not be liable for any loss to, or diminution
                  of, the Trust Fund resulting from any act or omission in
                  connection with the affairs of the Trust, except to the extent
                  that such loss or diminution is directly caused by the
                  Trustee's breach of the standard of care set forth in section
                  3.2.

         3.3.2    The Trustee shall have no duty or responsibility with respect
                  to the administration of the Plan, the collection of
                  contributions required to be made under the Plan by the
                  Company, or employees of the Company, or for the adequacy of
                  the Trust Fund to meet and discharge any payments and
                  liabilities under the Plan.

         3.3.3    The Trustee shall not be responsible for any loss to or
                  diminution of the Trust Fund resulting from the acquisition,
                  retention, or sale of any assets of the Trust Fund made in
                  accordance with Directions.

         3.3.4    The Trustee shall not be liable to any person for any action
                  in accordance with Directions or failure to act in the absence
                  of Directions.

         3.3.5    Upon the expiration of ninety (90) days from the date of
                  mailing of any statements or reports provided for under
                  sub-section 3.1.10, the Trustee shall be released and
                  discharged from all liability and accountability to anyone
                  with respect to its acts and transactions during the period
                  covered by the statements, except with respect to those
                  identified by the Company under

<PAGE>

                                       6

                  section 4.1.7 and those which are a breach of the Trustee's
                  standard of care set forth in section 3.2.

         3.3.6    Provided reasonable care was exercised in the selection of any
                  counsel, auditors, advisors, agents or other persons employed
                  by the Trustee hereunder, the Trustee shall be fully protected
                  in acting in good faith on the opinion or advice of or
                  information obtained from any such counsel, auditors,
                  advisors, agents or other persons in relation to any matter
                  arising in the administration of the Trust Fund.

3.4      CONFLICT OF INTEREST

         The Trustee may and shall not be in breach of this Trust Agreement or
         liable to account to the Trust Fund for any profit or gain if it does:

         3.4.1    Appoint, employ, contract or deal with any Related Party in
                  discharging its responsibilities hereunder;

         3.4.2    Purchase, hold, sell, invest in or otherwise deal with
                  securities or other assets of the same class and nature as may
                  be held in the Trust Fund, whether for its own account or for
                  the account of another;

         3.4.3    Use in other capacities, for profit or otherwise, knowledge or
                  information gained in its capacity as Trustee under this Trust
                  Agreement; provided that such knowledge and information is not
                  used to prefer any other interests over the interests of the
                  Trust Fund and any such use does not adversely affect the
                  interest of the Trust Fund; or

         3.4.4    Invest the assets of the Trust Fund in the securities or other
                  assets of any Related Party.

3.5      POWERS OF THE TRUSTEE

         The Trustee is hereby vested with every power, right and authority
         necessary or desirable to enable the Trustee to administer the Trust
         Fund and carry out its responsibilities in accordance with this Trust
         Agreement. Where required under this Trust Agreement and subject to
         Section 5.1 hereof, the powers, rights and authorities shall only be
         exercised on Direction. Without restricting the generality of the
         foregoing, the Trustee shall have the full power and authority:

         3.5.1    To purchase, or otherwise acquire, as and when so directed by
                  the Company, the common shares of           and retain the
                  same in trust hereunder;

         3.5.2    To sell for cash, convey , exchange for other securities,
                  currencies or other assets, convert, transfer, or otherwise
                  dispose of any securities, currencies or

<PAGE>

                                       7

                  other assets held by it at any time, by any means considered
                  reasonable by the Trustee, and to receive the consideration
                  and grant discharges therefor;

         3.5.3    To commence, defend, adjust or settle suits or legal
                  proceedings in connection with the Trust Fund and to represent
                  the Trust Fund in any such suits or legal proceedings and to
                  keep the Company informed; provided, however, that the Trustee
                  shall not be obliged or required to do so unless it has been
                  indemnified to its satisfaction against all expenses and
                  liabilities sustained or anticipated by the Trustee by reason
                  thereof;

         3.5.4    To hold in trust any securities, currencies or other assets
                  which it may acquire hereunder and generally to exercise any
                  of the powers of an owner with respect to securities or other
                  assets held in the Trust Fund;

         3.5.5    To exercise any conversion privileges, subscription rights,
                  warrants or other rights or options available in connection
                  with any securities or other assets at any time held by the
                  Trustee, and to make any payments incidental thereto; to
                  consent to, or otherwise participate in or dissent from, the
                  reorganization, consolidation, amalgamation or merger of any
                  corporation, company or association, or to the sale, mortgage,
                  pledge or lease of the property of any corporation, company or
                  association, any of the securities of which may at any time be
                  held by it, and to do any act with reference thereto,
                  including the delegation of discretionary powers, the exercise
                  of options, the making of agreements or subscriptions and the
                  payment of expenses, assessments or subscriptions which it may
                  deem necessary or advisable in connection therewith;

         3.5.6    To vote personally, or by general or by limited proxy, any
                  securities or other assets which may be held by it at any
                  time, and similarly to exercise personally or by general or by
                  limited power of attorney any right appurtenant to any
                  securities or other assets held by it at any time;

         3.5.7    To renew or extend or participate in the renewal or extension
                  of any securities or other assets, upon such terms as it may
                  deem advisable, and to agree to a reduction in the rate of
                  interest on any security or other asset or of any guarantee
                  pertaining thereto, in any manner and to any extent that it
                  may deem advisable; to waive any default whether in the
                  performance of any covenant or condition of any security or
                  other asset, or in the performance of any guarantee, or to
                  enforce rights in respect of any such default in such manner
                  and to such extent as it may deem advisable; to exercise and
                  enforce any and all rights of foreclosure, to bid on property
                  on sale or foreclosure, to take a conveyance in lieu of
                  foreclosure with or without paying a consideration therefor
                  and in connection therewith to release the obligation on the
                  covenant secured by such security and to exercise and enforce
                  in any action, suit or proceeding at law or in equity any
                  rights or remedies in respect of any such security or
                  guarantee pertaining thereto;

<PAGE>

                                       8

         3.5.8    To register the securities or other assets of the Trust Fund
                  in its own name or in the names of its nominees or the
                  nominees of any subcustodian appointed under this Trust
                  Agreement or of any depository authorized under this Trust
                  Agreement, or in bearer form if the investment is not
                  registrable or it would not be in the best interest of the
                  Trust Fund to do otherwise;

         3.5.9    To keep the assets of the Trust Fund wholly or partly, in its
                  principal office or in any one or more of its branches in any
                  Province of Canada or at the office of any financial
                  institution that is authorized to act as a custodian of
                  securities by the laws of any country, province, state or any
                  other political subdivision of any country in which such
                  financial institution is located;

         3.5.10   To hold securities through the facilities of a domestic or
                  foreign depository or clearing agency which is duly authorized
                  to operate a book-based system (including a transnational
                  book-based system) in the country, province, state or other
                  political subdivision of any country in which such depository
                  or clearing agency is located;

         3.5.11   To make, execute, acknowledge and deliver any and all
                  conveyances, contracts, waivers, releases or other documents
                  of transfer and any and all other instruments in writing that
                  may be necessary or proper for the accomplishment of any of
                  the powers herein granted;

         3.5.12   To the extent permitted by the Income Tax Act (Canada),
                  applicable legislation and the regulations, policies and
                  administrative practices of the applicable federal and
                  provincial regulatory authorities as may from time to time
                  apply to the Plan, to borrow (including the right to borrow
                  from a Related Party) money against the assets of the Trust
                  Fund, on such terms and conditions as the Trustee may
                  determine;

         3.5.13   The Trustee may retain uninvested cash balances from time to
                  time on hand in the Fund and may, in its sole discretion:

                  (a)      hold the same on a pooled basis in a pooled trust
                           fund, pay interest thereon at the rate from time to
                           time established by Royal Trust and paid with respect
                           to cash balances so held for similar accounts;

                  (b)      hold such cash balances on deposit with a bank or
                           such other deposit taking institution in any
                           jurisdiction in such interest bearing account as
                           Royal Trust in its discretion may determine;

                  (c)      invest such cash balances in guaranteed investment
                           certificates of itself or any Related Party; or

                  (d)      invest such cash balances in units of such short term
                           investment funds as may be established by Royal Trust
                           or any Related Party by declaration of trust or
                           otherwise provided a copy of the applicable

<PAGE>

                                       9

                           declaration of trust or other constating
                           document is provided to the Company;

         3.5.14   To deposit any assets forming part of the Trust Fund,
                  including securities and documents of title held by
                  it hereunder, with any bank or other depository;

         3.5.15   In consultation with the Company, to employ such
                  counsel, auditors, advisors, agents or other persons
                  (who may be employed by the Company) as the Trustee
                  may deem necessary from time to time for the purpose
                  of discharging its duties hereunder and to pay out of
                  the Trust Fund their reasonable expenses and
                  compensation;

         3.5.16   To do all such acts, take all such proceedings and
                  exercise all such rights and privileges, although not
                  specifically mentioned herein, as the Trustee, may
                  deem necessary to administer the Trust Fund, and to
                  carry out the purposes of this Trust.

         The exercise of any one or more of the foregoing powers or any
         combination thereof from time to time shall not be deemed to
         exhaust the rights of the Trustee to exercise such power or
         powers or combination of them thereafter from time to time.

                                   ARTICLE IV
                             CONCERNING THE COMPANY

4.1      RESPONSIBILITIES OF THE COMPANY

         The Company shall:

         4.1.1    Have full responsibility for the administration of the Plan;

         4.1.2    Ensure that any Direction is in accordance with the provisions
                  of the Plan and applicable legislation;

         4.1.3    Provide the Trustee with a copy of the Plan and all amendments
                  thereto from time to time;

         4.1.4    Manage the investment of the assets of the Plan in accordance
                  with this Trust Agreement, applicable legislation and any
                  investment policy or guidelines applicable to the Plan,
                  including the appointment under Article V and supervision of
                  one or more Investment Managers for any portion of the assets
                  of the Plan;

         4.1.5    Review any statements of accounts provided by the Trustee in
                  accordance with sub-section 3.1.10 and notify the Trustee of
                  any errors, omissions or discrepancies as may be contained in
                  such statements;

<PAGE>

                                       10

         4.1.6    Provide the Trustee with such Directions, certificates or
                  other documentation or information as may be required by the
                  Trustee to fulfil its obligations under this Trust Agreement
                  or as the Trustee may reasonably request;

         4.1.7    Provide the Trustee with certified copies of the Company's
                  signing authorities, as set out in Schedule A, as amended from
                  time to time; and

         4.1.8    Provide the Trustee with any and all amendments to the Plan.

                                    ARTICLE V
                                   INVESTMENTS

5.1      INVESTMENT OF TRUST FUND

         The Trustee shall hold, invest and reinvest the Trust Fund strictly in
         accordance with Directions of the Company in common shares of
         ____________________, or in such deposits or short term investments as
         may be specified in the said written directions. In the absence of any
         specific directions by the Company respecting the short term investment
         of cash balances, the Trustee shall invest in such short term
         investments as it may select in its sole discretion as herein provided.
         The investment of the assets of the Plan shall not be limited in any
         way to investments authorized for trustees under any applicable
         federal, provincial or territorial legislation.

5.2      Notwithstanding any other provision of this Trust Agreement, the
         Trustee may dispose of any assets of the Trust Fund on such terms as
         the Trustee may determine, in order to pay any obligations imposed on
         the Trust Fund or to repay any loan authorized by this Trust Agreement.

                                   ARTICLE VI
                                 COMMUNICATIONS

6.1      AUTHORIZED OFFICERS

         6.1.1    All Directions of the Company given to the Trustee pursuant to
                  any of the provisions of this Trust Agreement shall be in
                  writing and signed by an authorized officer, person or other
                  representative of the Company and the Trustee shall be fully
                  protected in acting in accordance with such Direction.
                  Directions given by telefax, SWIFT, directly between
                  electro-mechanical or electronic terminals or devices shall be
                  deemed to be in writing and signed by an authorized
                  representative. The Company and each Investment Manager shall,
                  from time to time, provide the Trustee with a certificate
                  substantially in the form of Schedule A attached hereto
                  stating the name of the authorized officer, person or other
                  representative so authorized to act on

<PAGE>

                                       11

                  behalf of the Company or Investment Manager, together with
                  specimen signatures of all such officers, persons or other
                  representatives, and the Trustee shall be entitled to rely
                  upon the identification of such persons as specified in such
                  certificate as the persons entitled to act on the behalf of
                  the Company or Investment Manager for the purposes of this
                  Trust Agreement until a later certificate respecting the same
                  is delivered to the Trustee. To the extent provided under the
                  terms of the Plan or the policies and practices of the Company
                  in respect thereof, a Beneficiary may, through the Company,
                  issue Directions to the Trustee respecting the selection of
                  investments for the account of that Beneficiary. Any such
                  Direction received through the Company shall be deemed to be a
                  Direction from the Company and to have been signed by an
                  authorized person.

         6.1.2    The Trustee is authorized to act on telephone instructions.
                  The Company shall forward Directions confirming telephone
                  instructions on the same day that such verbal instructions are
                  given to the Trustee. The fact that such confirming Directions
                  are not received or that contrary instructions are received by
                  the Trustee shall in no way affect the validity of
                  transactions effected by the Trustee on the basis of the
                  telephone instructions and the Trustee shall be protected in
                  relying on such telephone instructions as if they were
                  Directions of the Company, and, when so given, shall be deemed
                  to have been effectively and sufficiently given for all
                  purposes of this Trust Agreement.

         6.1.3    Where the Company has extended an Interactive Voice Response
                  or such other automated communications facility to allow the
                  Beneficiaries to request information or issue instructions in
                  respect of their accounts in accordance with a certain
                  Administrative Agreement entered into by the Company and Royal
                  Trust Corporation of Canada, the Trustee shall respond to such
                  requests and instructions as and when received from Royal
                  Trust Corporation of Canada. The said requests and
                  instructions shall be deemed to be a properly authorized
                  Direction from the Company hereunder and the Trustee shall be
                  fully protected in acting thereon.

6.2      ADDRESSES FOR DIRECTIONS

         All Directions and notices required or permitted hereunder shall be
         bound to be given personally, or if sent by pre-paid ordinary mail or
         if transmitted by telegram, telegraph or telefax or telephone as
         follows:

<PAGE>

                                       12

         6.2.1    in the case of the Trustee:

                           Royal Trust Corporation of Canada
                           Royal Trust Tower, 7th Floor
                           77 King Street West
                           P.O. Box 7500, Station "A"
                           Toronto, Ontario
                           M5W 1P9

                           ATTENTION: Vice President, Pension Custody Services

                           TELEPHONE: (416) 955-2852

                           TELEFAX:   (416) 955-2630

         6.2.2    in the case of the Company:

                           Draxis Health Inc.
                           6870 Goreway Drive
                           Mississauga, Ontario
                           L4V 1P1

                           ATTENTION: Mr. James A. H. Garner

                           Telephone: (905) 677-0898 ext. 247
                           Telefax: (905) 677-5502

         or at such other address or number as the party to whom any such
         Direction or notice is to be given shall have last notified the party
         giving the same in the manner provided in this section.

6.3      DEEMED DELIVERY

         Any Direction or notice delivered personally shall be deemed to have
         been given on the day it is so given. Subject to disruptions in the
         postal service, any Direction or notice mailed shall be deemed to have
         been given and received on the fifth (5) business date following the
         date of mailing. Any Direction or notice given by telefax, SWIFT,
         directly between electro-mechanical or electronic terminals or other
         devices, or by telephone shall be deemed to have been given and
         received on the day it is brought to the attention of the Trustee's
         employee to whom it is addressed without thereby creating an obligation
         for the Trustee to constantly monitor its communication equipment
         provided however that a reasonable surveillance is performed within the
         normal business hours of the Trustee where such Direction is sent. The
         sender of a Direction shall have the obligation of ensuring that the
         Direction sent by him has been received by the Trustee and the Trustee
         shall not be held liable for an omission to act resulting from not
         receiving a Direction.

<PAGE>
                                      13

6.4      PROOF OF CONTENT

         The Trustee shall be entirely protected when relying on a Direction
         received pursuant to this Article VI and in case of discrepancies
         between the copy or material representation of a Direction held or
         produced by the Trustee and such copy or representation held or
         produced by any person, the copy or material representation held or
         produced by the Trustee shall be deemed to constitute conclusive
         evidence of the content of such Direction.

                                   ARTICLE VII
                        RESIGNATION, REMOVAL, APPOINTMENT
                           AND REMUNERATION OF TRUSTEE

7.1      RESIGNATION

         The Trustee may resign at any time after giving ninety (90) days'
         notice in writing to the Company.

7.2      REMOVAL

         The Company shall have power to remove the Trustee exercisable in
         writing without notice, at any time that:

         7.2.1    the Trustee shall be declared bankrupt or shall be insolvent;

         7.2.2    the assets or the business of the Trustee shall become liable
                  to seizure or confiscation by any public or governmental
                  authority; or

         7.2.3    the Trustee shall cease to have the qualifications set out in
                  section 7.5.

         The Company may remove the Trustee for any reason at any time upon
         ninety (90) days' notice in writing or upon such shorter notice as may
         be mutually agreed by the Company and the Trustee.

7.3      APPOINTMENT OF SUCCESSOR

         In the event of resignation or removal of the Trustee under this Trust
         Agreement or in the case a vacancy shall arise in trusteeship of the
         Trust Fund, the Company shall appoint a trustee or other funding agent
         as successor to the Trustee and shall ensure that such successor has
         the qualifications set out in section 7.5.

         Notwithstanding the foregoing, any trust company resulting from the
         merger or amalgamation of the Trustee with one or more trust companies
         and any trust company which succeeds to substantially all of the trust
         business of the Trustee shall thereupon become the successor trustee
         hereunder without further act or formality.

<PAGE>

                                       14

7.4      OBLIGATIONS UPON RESIGNATION OR REMOVAL

         In the event of the resignation or removal of the Trustee, the Trustee
         shall, upon Direction of the Company, transfer title to all assets
         comprising the Trust Fund and all books and records maintained by the
         Trustee for the purpose of its responsibilities under this agreement to
         the successor appointed under section 7.3. Upon such transfer the
         Trustee shall be relieved of all responsibilities under this Trust
         Agreement.

7.5      QUALIFICATIONS OF TRUSTEE

         No person shall at any time be eligible to be appointed as successor to
         the Trustee other than a person permitted in accordance with applicable
         legislation.

7.6      FEES AND EXPENSES OF THE TRUSTEE

         The Trustee shall be entitled to such compensation as may from time to
         time be mutually agreed upon in writing by the Trustee and the Company.
         Such compensation and all other disbursements made and expenses
         incurred in the performance of the duties of the Trustee hereunder or
         arising out of this trust shall constitute a charge upon the Trust Fund
         and shall be paid out of the Trust Fund unless such compensation,
         disbursements and expenses shall be paid by the Company within thirty
         (30) days of the date the Trustee sends to the Company an invoice or
         account for same by any means described in section 6.3 for the giving
         of notice. The Trustee is authorized to pay out of the Trust Fund on
         Directions from the Company, the compensation, disbursements and
         expenses (including any applicable value added tax payable) of others
         and of the Company relating to the administration of the Plan and the
         trust.

                                  ARTICLE VIII
                  AMENDMENT AND TERMINATION OF TRUST AGREEMENT

8.1      AMENDMENT OF TRUST AGREEMENT

         The Company and Trustee reserve the right at any time and from time to
         time to amend, in whole or in part, any or all of the provisions of
         this Trust Agreement by notice thereof in writing delivered to the
         other party, provided that no such amendment which affects the rights,
         duties or responsibilities of the other party may be made without its
         consent. The Company and Trustee shall review the terms of this Trust
         Agreement at least every three years, and if necessary or advisable,
         amend the Agreement.

         Such review process shall not affect in any way whatsoever the
         continued validity and enforceability of this Trust Agreement.

8.2      TERMINATION OF TRUST AGREEMENT

         This Trust Agreement may be terminated at any time by an instrument in
         writing executed by the Company and the Trustee.

<PAGE>

                                       15

         Upon such termination, the Trust Fund shall be paid out by the Trustee
         on Direction of the Company subject to subsection 4.1.6 provided:

         8.2.1    any fees and expenses payable under this Trust Agreement from
                  the Trust Fund, shall first be deducted and paid;

         8.2.2    no such payment, except one made under section 8.2.1 shall be
                  made without satisfactory evidence being provided to the
                  Trustee that such approvals of appropriate federal or
                  provincial authorities, as may be required under any
                  legislation or regulations, have been obtained; and

         8.2.3    the provisions of this Trust Agreement shall survive any
                  termination until all assets comprising the Trust Fund have
                  been paid out or distributed.

                                   ARTICLE IX
                                  MISCELLANEOUS

9.1      SEVERANCE OF ILLEGAL OR INVALID PROVISION

         If any provision of this Trust Agreement shall be held illegal or
         invalid for any reason by a Court of competent jurisdiction, such
         illegality or invalidity shall not affect the remaining provisions of
         this Trust Agreement but this Trust Agreement shall be construed and
         enforced as if such illegal or invalid provision had never been
         inserted herein.

9.2      ASSIGNMENT

         This Trust Agreement may not be assigned by the Trustee without the
         consent in writing of the Company but may be assigned by the Company to
         a successor in the business of the Company or to a corporation with
         which the Company may amalgamate or merge or a corporation resulting
         from any reconstruction or reorganization of the Company.

9.3      INTERPRETATION

         Unless the context requires otherwise, any terms or provisions
         importing the plural shall include the singular and vice versa and any
         terms or provisions importing the masculine gender shall include the
         feminine gender.

9.4      GOVERNING LAW

         This Trust Agreement shall be construed, administered and enforced
         according to the laws of the Province of Ontario and the laws of Canada
         applicable therein and the Trustee shall be liable to account only in
         the Courts of that Province.

<PAGE>

                                       16

9.5      ENTIRE AGREEMENT

         This Trust Agreement and any schedules or exhibits hereto constitute
         the whole and entire agreement between the parties in respect of the
         subject matter hereof and cancel and supersede any prior written or
         verbal agreements including undertakings, declarations or
         representations made with respect thereto.

IN WITNESS WHEREOF the parties have caused this Trust Agreement to be executed
by their respective duly authorized officers effective as of the day and year
first above written.

                                             DRAXIS HEALTH INC.

                                             /s/ James A.H. Garner
                                             -----------------------------------
                                             NAME

                                             SVP & CFO
                                             -----------------------------------
                                             TITLE

                                             /s/ J. Le Saux
                                             -----------------------------------
                                             NAME

                                             Senior Vice President, Secretary
                                             and Chief Development Officer
                                             -----------------------------------
                                             TITLE

                                             ROYAL TRUST CORPORATION OF CANADA

                                             -----------------------------------
                                             NAME

                                             -----------------------------------
                                             TITLE

                                             -----------------------------------
                                             NAME

                                             -----------------------------------
                                             TITLE

<PAGE>

                       SCHEDULE "A" TO THE TRUST AGREEMENT
                             (the "Trust Agreement")
                           ESTABLISHING THE TRUST FUND
             FOR THE DRAXIS HEALTH INC. EMPLOYEE STOCK OWNERSHIP PLAN
                    DATED AS OF THE_____DAY OF_________, 19____

                   CERTIFICATE OF AUTHORIZED SIGNING OFFICERS

The following are specimen signatures of persons, duly authorized to give all
communications of the Draxis Health Inc. to Royal Trust Corporation of Canada
pursuant to the Trust Agreement.

The Draxis Health Inc. assumes responsibility for amending this list from time
to time.

          Signature:  /s/ J.A.H. GARNER
                    ---------------------------------------
          Name:       J.A.H. GARNER
                    ---------------------------------------
          Title:      SVP & CFO
                    ---------------------------------------

          Signature:  /s/ J. Le Saux
                    ---------------------------------------

          Name:       Jacqueline Le Saux
                    ---------------------------------------
                      Senior Vice President, Secretary
          Title:      and Chief Development Officer
                    ---------------------------------------

          Signature:  /s/ Dr. Martin Barkin
                    ---------------------------------------

          Name:       Dr. Martin Barkin
                    ---------------------------------------

          Title:      President and CEO
                    ---------------------------------------

          Signature:  /s/ Douglas M. Parker
                    ---------------------------------------

          Name:       DOUGLAS M. PARKER
                    ---------------------------------------

          Title:      DIRECTOR, LEGAL AFFAIRS
                    ---------------------------------------

          Signature:
                    ---------------------------------------

          Name:
                    ---------------------------------------

          Title:
                    ---------------------------------------

                              Certified by
Date:                         Authorized Signatory:  /s/ J. Le Saux
     ---------------                               -----------------------------

<PAGE>

                               DRAXIS HEALTH INC.
                          Employee Stock Ownership Plan
                      Summary Terms and Conditions (Revised(1))

                                                                           FINAL
                                                                 January 4, 1999

Purpose                             To develop the interest and incentive of
                                    employees in owning and retaining Draxis
                                    common shares.

Participants                        EMPLOYEES OF DRAXIS HEALTH INC. AND ITS
                                    SUBSIDIARIES.

                                    THE PROVISION CURRENTLY IN THE PLAN
                                    REQUIRING CONTINUOUS EMPLOYMENT FROM JUNE
                                    30TH TO DECEMBER 31ST OF A GIVEN YEAR WILL
                                    BE DELETED.

Notification                        PRIOR TO DECEMBER 31 OF EACH YEAR,
                                    PARTICIPANTS WILL INDICATE WHETHER THEY WISH
                                    NOT TO PARTICIPATE IN THE PLAN FOR THE YEAR
                                    THEN ENDING. IN THE ABSENCE OF SUCH NOTICE,
                                    ALL EMPLOYEES WILL BE ASSUMED TO BECOME
                                    PARTICIPANTS FOR THE YEAR THEN ENDING.

Employee Shares                     THE PROVISIONS CURRENTLY IN THE PLAN
                                    REGARDING EMPLOYEE SHARES (I.E. ELECTED
                                    NUMBER) WILL BE DELETED.

Plan Shares                         FOR EACH PARTICIPANT, THAT NUMBER OF COMMON
                                    SHARES ("PLAN SHARES") EQUAL TO 7% OF THE
                                    PARTICIPANT'S TOTAL CASH COMPENSATION FOR
                                    THE YEAR (INCLUDING SALARY PLUS BONUS)
                                    DIVIDED BY THE CLOSING SHARE PRICE ON THE
                                    TORONTO STOCK EXCHANGE ON THE LAST BUSINESS
                                    DAY OF DECEMBER WILL BE ACQUIRED BY AND
                                    DEPOSITED INTO THE TRUST.

                                    PAYMENT FOR PLAN SHARES WILL BE FUNDED
                                    THROUGH AN INTEREST-FREE LOAN TO THE
                                    EMPLOYEE FROM THE COMPANY, WHICH WILL BE
                                    RECOURSE ONLY TO THE PLAN SHARES.

                                    IF AT ANY TIME THE PLAN SHARES, PLEDGED AS
                                    SECURITY FOR AN INTEREST-FREE LOAN, ARE
                                    ACCEPTED BY THE TRUST IN SATISFACTION OF THE
                                    LOAN, AN AMOUNT WILL (DEPENDING UPON THE
                                    TERMS OF THE PLAN) BE INCLUDABLE IN THE
                                    PARTICIPANT'S INCOME EQUAL TO THE
                                    DIFFERENCE, IF ANY, BETWEEN THE AMOUNT OF
                                    THE LOAN OUTSTANDING AND THE VALUE OF THE
                                    PLAN SHARES AT THAT TIME.

                                    FOR PURPOSES OF THE PLAN AND REGARDLESS OF
                                    THE ACTUAL PURCHASE PRICE, PLAN SHARES WILL
                                    BE DEEMED TO BE ACQUIRED BY THE TRUST AT THE
                                    CLOSING SHARE PRICE ON THE TORONTO STOCK
                                    EXCHANGE ON THE LAST BUSINESS DAY OF
                                    DECEMBER.

----------
(1) PROPOSED MODIFICATIONS TO THE PLAN ARE SHOWN IN BOLDFACE.

<PAGE>

ESPBP

Plan Shares (continued)             PLAN SHARES WILL BE RELEASED 20%, 20%, 20%,
                                    20% AND 20% IN THE JANUARY FOLLOWING THE
                                    1ST, 2ND , 3RD, 4TH AND 5RD ANNIVERSARIES
                                    ("RELEASE DATES") OF INITIAL PURCHASE
                                    FOLLOWING PAYMENT OF THE RELATED PRINCIPAL
                                    AMOUNT OF THE INTEREST-FREE LOAN.

                                    THE INTEREST-FREE LOAN WILL BE SATISFIED ON
                                    EACH RELEASE DATE BY DRAXIS DECLARING A CASH
                                    BONUS FOR EACH PARTICIPANT IN THE AMOUNT OF
                                    THE RELATED PRINCIPAL AMOUNT OF THE
                                    INTEREST-FREE LOAN. SUCH BONUS WILL BE
                                    TAXABLE WHEN IT IS RECEIVED. THE FULL
                                    PRE-TAX PORTION OF THE BONUS WILL BE PAID TO
                                    THE TRUST IN SATISFACTION OF THE INTEREST
                                    FREE LOAN. SHARE CERTIFICATES REPRESENTING
                                    THE PLAN SHARES WILL BE RELEASED TO
                                    PARTICIPANTS FOLLOWING PAYMENT BY THE
                                    PARTICIPANT OF THE REQUISITE WITHHOLDINGS ON
                                    THE AMOUNT OF BONUS.

                                    ONCE RELEASED FROM THE TRUST, PLAN SHARES
                                    MAY BE SOLD AT ANY TIME, SUBJECT TO THE
                                    COMPANY'S POLICIES GOVERNING TRADING IN ITS
                                    SHARES.

TERMINATION OF EMPLOYMENT           PARTICIPANTS ARE ENTITLED TO RECEIVE PLAN
                                    SHARES FOLLOWING TERMINATION OF EMPLOYMENT
                                    DUE TO DEATH, PERMANENT DISABILITY OR
                                    RESIGNATION AFTER AGE 60, IN THE SAME MANNER
                                    AS IF THEY HAD CONTINUED THEIR EMPLOYMENT
                                    WITH THE COMPANY. PARTICIPANTS WILL LOSE
                                    THEIR ENTITLEMENT TO PLAN SHARES FOLLOWING
                                    TERMINATION OF EMPLOYMENT FOR ANY OTHER
                                    REASON.

CHANGE OF CONTROL                   THE TAKE-OVER BID PROVISIONS OF THE PLAN
                                    WILL BE EXPANDED SO AS TO COVER THE
                                    FOLLOWING CHANGE OF CONTROL SCENARIOS TO
                                    MAKE THE PLAN CONSISTENT WITH THE PROVISIONS
                                    OF THE COMPANY'S STOCK OPTION AND EMPLOYEE
                                    PARTICIPATION SHARE PURCHASE PLANS IN THIS
                                    AREA.

                                    A CHANGE OF CONTROL WILL BE DEFINED AS:

                                    (a)      AN OFFEROR MAKES A CASH OFFER OR AN
                                             EXCHANGE OFFER TO PURCHASE 50% OR
                                             MORE OF THE OUTSTANDING SHARES TO
                                             SUBSTANTIALLY ALL HOLDERS OF THE
                                             SHARES;

                                    (b)      AN INSIDER MAKES AN OFFER TO
                                             PURCHASE SHARES TO SUBSTANTIALLY
                                             ALL HOLDERS OF THE SHARES;

                                    (c)      AN OFFEROR MAKES AN OFFER, BY WAY
                                             OF MERGER, AMALGAMATION,
                                             REORGANIZATION, CONSOLIDATION,
                                             EXCHANGE OR OTHERWISE, THE RESULT
                                             OF WHICH WOULD BE THE ACQUISITION
                                             BY SUCH OFFEROR, DIRECTLY OR
                                             INDIRECTLY, OF 50% OR MORE OF THE
                                             OUTSTANDING EQUITY SECURITIES OF
                                             THE COMPANY OR THE SUCCESSOR
                                             ENTITY; OR

                                    (d)      AN OFFEROR MAKES AN OFFER TO
                                             PURCHASE SUBSTANTIALLY ALL OF THE
                                             ASSETS OF THE COMPANY;

                                    AND THE BOARD OF DIRECTORS RECOMMENDS
                                    ACCEPTANCE OF SUCH OFFER TO THE SHAREHOLDERS
                                    OF THE COMPANY.
--------------------------------------------------------------------------------
                                                                     Page 2 of 4
<PAGE>

ESPBP

CHANGE OF CONTROL (CONTINUED)       UPON A CHANGE OF CONTROL TYPE (a), (b) OR
                                    (c):

                                    (i) ALL PLAN SHARES HELD BY THE TRUST WOULD
                                    BE TENDERED OR VOTED IN FAVOUR OF THE
                                    PROPOSED TRANSACTION; AND (ii) IN THE
                                    EVENT THE PROPOSED TRANSACTION IS
                                    SUCCESSFUL, THE COMPANY WOULD DECLARE A
                                    CASH BONUS FOR EACH PARTICIPANT IN THE
                                    AMOUNT OF ALL OUTSTANDING PROMISSORY NOTES
                                    PAYABLE. THE FULL PRE-TAX PORTION OF THE
                                    BONUS WILL BE PAID TO THE TRUST IN
                                    SATISFACTION OF THE INTEREST-FREE LOANS. THE
                                    CONSIDERATION PURSUANT TO THE TRANSACTION
                                    WILL BE RELEASED TO PARTICIPANTS FOLLOWING
                                    PAYMENT BY THEM OF THE REQUISITE
                                    WITHHOLDINGS ON THE AMOUNT OF BONUS.

                                    UPON A CHANGE OF CONTROL TYPE (d):

                                    (i) ALL PLAN SHARES HELD BY THE TRUST WOULD
                                    BE VOTED IN FAVOUR OF THE PROPOSED
                                    TRANSACTION; AND (ii) IN THE EVENT THE
                                    PROPOSED TRANSACTION IS SUCCESSFUL, THE
                                    COMPANY WOULD DECLARE A CASH BONUS FOR EACH
                                    PARTICIPANT IN THE AMOUNT OF ALL OUTSTANDING
                                    PROMISSORY NOTES PAYABLE. THE FULL PRE-TAX
                                    PORTION OF THE BONUS WILL BE PAID TO THE
                                    TRUST IN SATISFACTION OF THE INTEREST FREE
                                    LOANS. ALL PLAN SHARES WILL BE RELEASED TO
                                    PARTICIPANTS FOLLOWING PAYMENT BY THEM OF
                                    THE REQUISITE WITHHOLDINGS ON THE AMOUNT OF
                                    BONUS.

                                    IN THE EVENT THE BOARD OF DIRECTORS DOES NOT
                                    RECOMMEND ACCEPTANCE OF A CHANGE OF CONTROL
                                    OFFER, THE PLAN SHARES WOULD BE VOTED IN
                                    ACCORDANCE WITH THE BOARD RECOMMENDATION.
                                    HOWEVER, IN THE EVENT A CHANGE OF CONTROL
                                    TAKES PLACE NOTWITHSTANDING THE BOARD'S
                                    RECOMMENDATION AGAINST THE OFFER, THE
                                    CONSEQUENCES DESCRIBED ABOVE RELATING TO A
                                    RECOMMENDED CHANGE OF CONTROL SHALL APPLY.
                                    IN THE EVENT A CHANGE OF CONTROL DOES NOT
                                    TAKE PLACE THE PROVISIONS OF THE PLAN AS
                                    THEY EXISTED PRIOR TO RECEIVING A CHANGE OF
                                    CONTROL OFFER WILL APPLY.

Source of Shares                    All Plan Shares purchased by the Trust will
                                    be purchased on the Toronto Stock Exchange.

Administration Costs                All costs of administration of the Plan will
                                    be borne by the Company.

Commissions                         Commissions on the purchase of Plan Shares
                                    by the Trust will be paid by the Company.
                                    Commissions on the sale of shares are borne
                                    by the seller.

Voting                              Other than as provided for under "Change of
                                    Control", Plan Shares held by the Trust will
                                    be voted according to the directions of the
                                    employees for whom the shares are held.

--------------------------------------------------------------------------------
                                                                     Page 3 of 4

<PAGE>

ESPBP

DISTRIBUTIONS                       DISTRIBUTIONS (EG DIVIDENDS) IN RESPECT OF
                                    PLAN SHARES HELD BY THE TRUST WILL FLOW
                                    THROUGH TO THE EMPLOYEES FOR WHOM THE SHARES
                                    ARE HELD AND DISTRIBUTED TO THOSE EMPLOYEES
                                    UPON RELEASE OF THE SHARES TO WHICH SUCH
                                    DISTRIBUTIONS RELATE.

APPLICATION                         ALL PROVISIONS SET FORTH HEREIN WILL HAVE
                                    EFFECT FROM THE PARTICIPATION PERIOD
                                    BEGINNING DECEMBER 1998.

                                    PROVISIONS DESCRIBED UNDER "TERMINATION OF
                                    EMPLOYMENT" AND "CHANGE OF CONTROL" WILL
                                    ALSO HAVE EFFECT FOR PREVIOUS PARTICIPATION
                                    YEARS.

REVIEW DATE                         A FULL REVIEW OF THE PLAN WILL BE CONDUCTED
                                    AS AT DECEMBER 31, 1999.

--------------------------------------------------------------------------------
                                                                     Page 4 of 4<PAGE>

                                                                    Exhibit 4.12

                             DRAXIS HEALTH INC.

                 EMPLOYEE PARTICIPATION SHARE PURCHASE PLAN

               MADE EFFECTIVE THE 16TH DAY OF FEBRUARY, 1995

<PAGE>

                             DRAXIS HEALTH INC.

                 EMPLOYEE PARTICIPATION SHARE PURCHASE PLAN

<TABLE>
<S>  <C>                                                              <C>
1.   Definitions.....................................................  1

2.   Administration..................................................  9

3.   Subscription for Employee Participation Shares..................  9

4.   Issuance of Employee Participation Shares....................... 11

5.   Conversion...................................................... 11

6.   Change in Employee Participation Shares......................... 11

7.   Merger, etc..................................................... 12

8.   Redemption...................................................... 13

9.   Termination of Employment....................................... 13

10.  Conditions Precedent to Exercise of Conversion Right............ 14

11.  Right of Corporation............................................ 14

12.  No Additional Amounts Payable................................... 14

13.  Amendment or Discontinuance of Plan............................. 15

14.  Shareholders' Approval.......................................... 15

15.  Notice.......................................................... 15

16.  Governing Law................................................... 16

17.  Entire Agreement................................................ 16

18.  No Assignment or Transfer....................................... 16

19.  Benefit of Plan................................................. 17
</TABLE>

<PAGE>

                             DRAXIS HEALTH INC.

                 EMPLOYEE PARTICIPATION SHARE PURCHASE PLAN

                 Made Effective the 16th day of February, 1995.

     WHEREAS the Corporation has an authorized share capital which includes
Employee Participation Shares;

     AND WHEREAS the Corporation desires to enable its designated employees
to acquire Employee Participation Shares on the terms hereinafter set forth;

     NOW THEREFORE the Corporation hereby establishes this Employee
Participation Share Purchase Plan with effect as of the 16th day of February,
1995, as follows:

1.   DEFINITIONS

     In this Plan and in each Employee Participation Share Purchase
Agreement, unless the context otherwise requires:

     "Act" means the Canada Business Corporations Act as now enacted or as
     the same may from time to time be amended, re-enacted or replaced;

     "Administrator" means the Compensation Committee of the Board of
     Directors of the Corporation;

     "Automatic Conversion Date" in respect of Employee Participation Shares
     of a particular series means and refers to the date that is the fifth
     anniversary date of the date of issue of such shares as described in the
     Series Provisions and is the date on which all Employee Participation
     Shares of that series subscribed for

<PAGE>

                                      -2-

     thereunder will, to the extent not theretofore redeemed, be converted
     into Common Shares;

     "Board of Directors" means the Board of Directors of the Corporation;

     "Business Day" means a day other than a Saturday, Sunday or statutory
     holiday in the Province of Ontario, provided that the principal offices of
     the Corporation in Mississauga, Ontario are open for business on the
     particular day;

     "Change of Control" shall mean circumstances where:

     (a)   an offeror makes a cash offer or an exchange offer to purchase 50%
           or more of the outstanding Common Shares to substantially all
           holders of the Common Shares;

     (b)   an insider of the Corporation makes an offer to purchase Common
           Shares to substantially all holders of the Common Shares;

     (c)   an offeror makes an offer, by way of merger, amalgamation,
           reorganization, consolidation, exchange or otherwise, the result of
           which would be the acquisition by such offeror directly or indirectly
           of 50% or more of the outstanding equity securities of the
           Corporation or the successor entity; or

     (d)   an offeror makes an offer to purchase substantially all of the
           assets of the Corporation;

     and the Board of Directors recommends acceptance of such offer to the
     shareholders of the Corporation or, if the Board of Directors has made
     no recommendation, the shareholders have approved or accepted the
     proposed offer.

<PAGE>

                                      -3-

     "Common Share" means a common share in the capital of the Corporation,
     the rights, privileges, restrictions and conditions attaching to which
     include provisions to the effect that each Common Share entitles the
     holder:

     (i)   to receive notice of and to attend all annual and special meetings
           of the shareholders of the Corporation and to one vote in respect of
           each Common Share held at all such meetings;

     (ii)  to receive rateably with the holders of Common Shares such
           dividends, if, as and when declared by the Board of Directors out
           of the assets of the Corporation properly applicable to the
           payment of dividends in such amounts and payable in such manner,
           as the Board of Directors may from time to time declare, subject
           to the rights of the holders of any other class of shares of the
           Corporation entitled to receive dividends in priority to or rateably
           with the holders of the Common Shares; and

     (iii) in the event of the liquidation, dissolution or winding-up of the
           Corporation or other distribution of the assets of the Corporation
           among its shareholders for the purpose of winding-up its affairs,
           the holders of the Common Shares shall, subject to the rights of
           the holders of any other class of shares of the Corporation
           entitled to receive the assets of the Corporation upon such
           distribution in priority to or rateably with the holders of the
           Common Shares, be entitled to participate rateably in any
           distribution of the remaining assets of the Corporation, after
           preferential distributions to holders of any other shares of the
           Corporation the holders of which are entitled to participate in a
           distribution of assets in priority to holders of the Common Shares;

     "Compensation Committee" means a committee comprised of certain members
     of the Board of Directors and vested with responsibility to address issues
     relating to matters of compensation;

<PAGE>

                                      -4-

     "Conversion Date" in respect of Employee Participation Shares of a
     particular series means any Business Day following the date on which
     Employee Participation Shares of that series were issued, provided however
     no Conversion Date shall include a date other than the Automatic Conversion
     Date unless on or prior to such date the Minimum Vesting Period has expired
     and the Fair Market Value of the Common Shares on such date is at least
     twenty-five percent (25%) greater than the Fair Market Value of the Common
     Shares on the issue date of the particular series of Employee
     Participation Shares;

     "Corporation" means Draxis Health Inc.;

     "Employee" means each full-time employee of the Corporation with whom
     the Corporation enters into an Employee Participation Share Purchase
     Agreement and such directors and other employees of the Corporation as the
     Compensation Committee in its sole discretion determines;

     "Employee Participation Share" means a special share of any series in
     the capital of the Corporation, which is designated as an "Employee
     Participation Share", a separate series of which shall be created for all
     shares having identical attributes in respect of each Subscription Date on
     which Employee Participation Shares are issued and which provides that:

     (i)   each Employee Participation Share entitles the holder to receive
           cash dividends, if any, as may from time to time be declared payable
           thereon, at the same time as dividends, if any, are paid on Common
           Shares, in an amount for each Employee Participation Share of a
           particular series which is equal to the proportion of the amount of
           the dividend declared on each common share that the applicable
           Subscription Price is of the Fair Market Value of the Common Shares
           at the date of issuance of the Employee Participation Share.

<PAGE>

                                      -5-

     (ii)  in the event of a proposal, order or resolution for the liquidation,
           dissolution or winding-up of the Corporation, whether voluntary or
           involuntary, the Employee Participation Shares will become Common
           Shares on the basis of the formula described in paragraph (iii)
           below;

     (iii) each Employee Participation Share of a particular series issued
           and outstanding automatically becomes part of a Common Share on the
           Automatic Conversion Date or at the option of a holder of an
           Employee Participation Share on a Conversion Date other than the
           Automatic Conversion Date and the number of Common Shares an
           employee receives is the number of Common Shares which is
           determined by multiplying the number of Employee Participation
           Shares of a particular series which the Employee elects to convert
           by the following fraction:

           A.  the numerator of which shall be the Employee Participation
               Share Value of an Employee Participation Share of a particular
               series as at the earlier of the Automatic Conversion Date and a
               Conversion Date as the case may be; and

           B.  the denominator of which shall be the Fair Market Value of a
               Common Share as at the earlier of the two dates described in A,

           provided that no fractional Common Shares will be issued. No
           payment will be made in respect of fractional Common Shares;

     (iv)  no Employee Participation Share shall entitle the holder to vote
           at meetings of shareholders of the Corporation except in special
           circumstances prescribed under the Act;

     (v)   the Corporation may purchase an Employee Participation Share at
           any time for cancellation at its issue price.

<PAGE>

                                      -6-

     (vi)  any right of conversion of an Employee Participation Share into a
           Common Share, other than a conversion of such a share occurring on
           an Automatic Conversion Date, shall be exercised by notice in writing
           given to the Corporation.

     "Employee Participation Share Purchase Agreement" means a subscription
     agreement substantially in the form annexed hereto as Exhibit A entered
     into between an Employee and the Corporation pursuant to which the
     Employee subscribes for, and the Corporation issues, Employee
     Participation Shares;

     "Employee Participation Share Value" in respect of an Employee
     Participation Share of a particular series as at a particular time means
     the greater of:

     (i)   the amount, if any, by which the Fair Market Value of a Common
           Share as at that time exceeds the Fair Market Value of a Common
           Share as at the date on which the first Employee Participation Share
           of that series was issued; and

     (ii)  the Subscription Price;

     "Fair Market Value" of a Common Share at a particular time means the
     average of the daily high and low board lot trading prices on The Toronto
     Stock Exchange on each of the five trading days immediately preceding
     the date on which such value is to be determined;

     "Minimum Vesting Period" in respect of a particular Employee Participation
     Share means, except as otherwise mutually agreed upon by the Employee and
     the Corporation, the period of time commencing at the time of issuance of
     such Employee Participation Share of a particular series and ending on an
     anniversary date of such issuance and occurring in such percentages as
     follows:

<PAGE>

                                      -7-

<TABLE>
     <S>                       <C>

     Year 1         -          20%

     Year 2         -          20%

     Year 3         -          20%

     Year 4         -          40%
</TABLE>

     "Plan" means this Employee Participation Share Purchase Plan, as amended
     or supplemented from time to time;

     "Redemption Amount" of an Employee Participation Share of a particular
     series at a particular time means the aggregate of:

     (i)   the Subscription Price; and

     (ii)  the amount, if any, of all dividends theretofore declared thereon
           but unpaid at that time;

     "Redemption Date" means any Business Day before the Automatic Conversion
     Date on which the Corporation proposes to purchase for cancellation an
     Employee Participation Share;

     "Reserved Shares" means the number of Common Shares reserved by the
     Board of Directors and approved by shareholders for issuance under the
     Plan, and stock option plans, options for services and treasury stock
     purchase plans of the Corporation;

     "Series Provisions" means the rights, privileges, restrictions and
     conditions attaching to a series of Employee Participation Shares
     including those described in the definition of an Employee Participation
     Share;

<PAGE>

                                      -8-

     "Subscription Date" means the date on which an Employee subscribes for
     Employee Participation Shares and executes an Employee Participation Share
     Purchase Agreement;

     "Subscription Price" means the subscription price paid by an Employee
     pursuant to the Employee Participation Share Purchase Agreement for an
     Employee Participation Share; and

     "Termination" in respect of an Employee means the termination of all
     employment, offices or directorship of the Employee with the Corporation
     whether for any cause or for no cause and whether at the instance of the
     Corporation, the Employee or otherwise, including termination by reason
     of the death of the Employee.

2.   ADMINISTRATION

     Subject to Section 13, this Plan shall be administered by the
Administrator; provided that the Board of Directors may exercise any powers
reserved herein for the Administrator. Subject to the terms of the Plan, the
Administrator is authorized to construe and interpret the Plan, to prescribe,
amend, and rescind rules and regulations relating to the Plan, and to make
all determinations and take all actions necessary or advisable for the Plan's
administration. The Administrator shall act by vote or written consent of a
majority of its members. Whenever the Plan authorizes or requires the
Administrator to take any action, make any determination or decision, or form
any opinion, then any such action, determination, decision, or opinion by or
of the Administrator shall be in the absolute discretion of the
Administrator. The specified maximum number of Employee Participation Shares
issuable pursuant to this Plan shall be 2,500,000.

<PAGE>

                                      -9-

3.   SUBSCRIPTION FOR EMPLOYEE PARTICIPATION SHARES

     The Administrator may, from time to time, in its sole discretion,
determine those Employees who shall be entitled to subscribe for Employee
Participation Shares under this Plan, the number of Employee Participation
Shares available to be subscribed for by each such Employee and the
Subscription Price to be paid for each such share.

     An Employee may subscribe for Employee Participation Shares by executing
and delivering to the Corporation an Employee Participation Share Purchase
Agreement entitling that Employee to subscribe for the number of Employee
Participation Shares therein specified and by paying to the Corporation on or
before the Subscription Date therein specified the Subscription Price therein
specified in respect of each Employee Participation Share for which the
Employee desires to subscribe; provided, however, that if it is subsequently
determined:

     (a)   by BONA FIDE agreement between the parties;

     (b)   by agreement among the parties and the Department of National
           Revenue; or

     (c)   by a court of competent jurisdiction;

that the Subscription Price referred to above is not equal to the fair market
value of the Employee Participation Shares to be subscribed for hereunder,
then the Subscription Price shall be adjusted to be increased or decreased so
as to equal the fair market value as so determined and such adjusted
Subscription Price shall be effective for all purposes from the date hereof;
provided that an adjustment under paragraph (b) above shall preclude an
adjustment under paragraph (a) and an adjustment under paragraph (c) above
shall be final and binding. Any such adjustment shall bear interest from the
Subscription Date at a rate equal to the prescribed rate of interest
calculated pursuant to Regulation 4301(a) of regulations to the Income Tax Act
(Canada). The Corporation agrees that if the

<PAGE>

                                     -10-

Subscription Price is subsequently adjusted to increase the cost of Employee
Participation Shares to the Employee, the Corporation shall lend to the
Employee under an interest-free, limited recourse loan an amount equal to the
aggregate of the amount of any such increase in the Subscription Price and
applicable interest thereon (the "Share Loan"). The Employee must apply the
proceeds of the Share Loan to pay such increased Subscription Price and
applicable interest thereon.

4.   ISSUANCE OF EMPLOYEE PARTICIPATION SHARES

     After receipt by the Corporation from the Employee of the Subscription
Price for Employee Participation Shares pursuant to section 3 hereof, the
Corporation shall, effective on the particular Subscription Date, issue to
the Employee as fully paid and non-assessable shares the number of Employee
Participation Shares of the particular series to which the Employee is
thereby entitled.

     Nothing herein contained or done pursuant hereto shall obligate the
Employee to purchase or pay for any Employee Participation Shares except
those in respect of which the Employee shall have so subscribed.

5.   CONVERSION

     An Employee may prior to the Automatic Conversion Date exchange an
Employee Participation Share of a particular series held by such Employee for
Common Shares subject to the Minimum Vesting Period and except as otherwise
provided herein. The number of Common Shares to which an Employee will be
entitled at any particular Conversion Date will be in accordance with the
particular Series Provisions as hereinbefore described.
<PAGE>

                                     -11-

6.   CHANGE IN EMPLOYEE PARTICIPATION SHARES

     In the event of any subdivision, redivision or consolidation or other
change of Common Shares, corresponding adjustments shall be made in
accordance with the Series Provisions with respect to any Common Shares to be
issued upon conversion of the Employee Participation Shares of each series.

7.   MERGER, ETC.

     (a)   In the event that the Corporation enters into an agreement with a
           person for the sale of all or substantially all of its assets or
           the Corporation sells all or substantially all of its assets, and in
           the event of a Change of Control of the Corporation, the Corporation,
           or failing the Corporation, the Administrator, shall forthwith
           deliver written notice of such event to the Employee and the Employee
           shall have the right, for a period of 21 days or such longer period
           as the Administrator may determine following receipt of the notice,
           to convert such of the Employee Participation Shares into Common
           Shares as the Employee may elect notwithstanding the fact that the
           Minimum Vesting Period has not expired.

     (b)   In the event that the Corporation enters into an agreement with a
           person for the merger, amalgamation or consolidation of the
           Corporation with or into any other company which is not a subsidiary
           of the Corporation within the meaning of the Act or the Corporation
           is merged, amalgamated or consolidated with or into any other company
           which is not a subsidiary of the Corporation within the meaning of
           the Act, the Corporation, or failing the Corporation, the
           Administrator, shall forthwith deliver written notice of such event
           to the Employee and the Employee shall have the right, for a period
           of 21 days following receipt of the notice, to convert such of the
           Employee Participation Shares into Common Shares as the Employee may

<PAGE>

                                     -12-

           elect notwithstanding the fact that the Minimum Vesting Period has
           not expired.

8.   REDEMPTION

     The Corporation reserves the right at any time without notice to redeem
or purchase for cancellation at any time all or part of the Employee
Participation Shares held by an Employee, whether or not a Minimum Vesting
Period has occurred.

9.   TERMINATION OF EMPLOYMENT

     In the event of a Termination of the Employee's employment, office or
directorship with the Corporation for any reason including death, compulsory
or voluntary retirement, disability, dismissal or resignation, (the date of
such event referred to herein as the "Termination Date"), the following rules
apply:

     (i)   if the Termination Date precedes the expiration of an applicable
           Minimum Vesting Period pertaining to any Employee Participation
           Shares then owned by the former Employee, unless the Administrator in
           its sole and unfettered discretion otherwise determines, the former
           Employee shall not be entitled to exercise any rights under the Plan
           or under the conditions attaching to any such Employee Participation
           Shares, including any right of conversion, and instead the
           Corporation shall redeem any such Employee Participation Shares for
           an amount equal to the Redemption Amount thereof and the former
           Employee shall forthwith surrender all such Employee Participation
           Shares to the Corporation for cancellation; or

     (ii)  if the Termination Date follows the expiration of an applicable
           Minimum Vesting Period pertaining to any Employee Participation
           Shares then owned by the former Employee, unless the Administrator
           in its sole and unfettered discretion otherwise determines, the
           former Employee shall be deemed to

<PAGE>

                                     -13-

           have converted all such Employee Participation Shares into Common
           Shares with effect on the date that is 30 days after the Termination
           Date, on the basis of the conversion ratio contemplated in the Series
           Provisions attaching to such Employee Participation Shares.

10.  CONDITIONS PRECEDENT TO EXERCISE OF CONVERSION RIGHT

     The automatic conversion of the Employee Participation Shares into
Common Shares on the fifth anniversary date of their issue shall be subject
to the condition that if at any time the Corporation shall determine in its
discretion that the satisfaction of withholding tax or other withholding
liabilities, or that the listing, registration or qualification of any shares
otherwise deliverable upon such exercise upon any securities exchange or
under any law, or the consent or approval of any regulatory body, is necessary
or desirable as a condition of, or in connection with, such change or the
delivery of shares thereunder, then in any such event such conversion shall
not be effective unless such withholding, listing, registration,
qualification, consent or approval shall have been effected or obtained free
of any conditions not acceptable to the Corporation.

11.  RIGHT OF CORPORATION

     Nothing herein shall affect the right of the Corporation to terminate
the employment of an Employee.

12.  NO ADDITIONAL AMOUNTS PAYABLE

     No interest, penalty, bonus or other amount (other than any dividend
declared on an Employee Participation Share or the Redemption Amount in
respect thereof) shall be payable by the Corporation by reason of the
operation of the Plan.

<PAGE>

                                     -14-

13.  AMENDMENT OR DISCONTINUANCE OF PLAN

     The Board of Directors may amend or discontinue the Plan at any time
subject to the consent of The Toronto Stock Exchange, but no such amendment
may alter or impair any Employee Participation Shares previously issued
except with the written consent of the holder of such Employee Participation
Shares.

14.  SHAREHOLDERS' APPROVAL

     The Plan shall be subject to the approval of The Toronto Stock Exchange
and any other applicable securities regulatory authority and the shareholders
of the Corporation to be given by resolution passed at a meeting of the
shareholders. The rights attaching to any Employee Participation Shares
issued prior to such approval have no force or effect unless such approval is
given. If the Plan is not approved, the Corporation will redeem the Employee
Participation Shares at their Redemption Amount.

15.  NOTICE

     Any notice or other document required or permitted to be given,
delivered or sent hereunder shall be in writing and shall be given, delivered
or sent by registered mail, postage prepaid, mailed and addressed to the
parties hereto respectively as follows:

To the Employee:            To the address noted in the particular Employee
                            Participation Share Purchase Agreement.

To the Corporation:         Draxis Health Inc.
                            6870 Goreway Drive
                            Mississauga, Ontario L4V 1P1

                            Attention:

or to such other address as the party entitled to receive the notice or other
document shall have communicated in writing to the other parties. Any such
notice or other document

<PAGE>

                                     -15-

given, delivered or sent as aforesaid shall be deemed to have been given,
delivered or sent and received on the fifth next Business Day following the
day on which it is mailed.

16.  GOVERNING LAW

     The Plan and each Employee Participation Share Purchase Agreement shall
be governed by and construed in accordance with the laws of Ontario.

17.  ENTIRE AGREEMENT

     This Plan and each particular Employee Participation Share Purchase
Agreement together constitute the entire agreement between the parties
thereto respecting the matters dealt with herein and therein.

18.  NO ASSIGNMENT OR TRANSFER

     Employee Participation Shares issued under the Plan and the Employee
Participation Share Purchase Agreement shall not be transferable by an
Employee, except

     (i)   to a trust governed by a registered retirement savings plan of the
           Employee, or

     (ii)  by way of devolution to one or more legal personal representatives
           of the Employee on the death of the Employee,

provided that in any case any such transferee of Employee Participation
Shares agrees to be bound by the terms of the Plan.

<PAGE>

                                     -16-

19.  BENEFIT OF PLAN

     All rights and obligations under the Plan shall enure to the benefit of
and be binding upon the heirs, executors, administrators, or other legal
personal representatives of the Employee and the successors and assigns of
the Corporation.

<PAGE>

[INDUSTRY CANADA LETTERHEAD]

July 14, 1995                                    Your file

MCCARTHY TETRAULT                                Our file
                                                            304758-0

Re

DRAXIS HEALTH INC./
SANTE DRAXIS INC.

Enclosed herewith is the document issued in the above matter.

A notice of issuance of CBCA documents will be published in the Canada
Corporations Bulletin. A notice of issuance of CCA documents will be published
in the Canada Corporations Bulletin and the Canada Gazette.

IF A NAME OR CHANGE OF NAME IS INVOLVED, THE FOLLOWING CAUTION SHOULD BE
OBSERVED:

This name is available for use as a corporate name subject to and conditional
upon the applicants assuming full responsibility for any risk of confusion with
existing business names and trade marks (including those set out in the relevant
NUANS search report(s)). Acceptance of such responsibility will comprise an
obligation to change the name to a dissimilar one in the event that
representations are made and established that confusion is likely to occur. The
use of any name granted is subject to the laws of the jurisdiction where the
company carries on business.

/s/      [ILLEGIBLE]

For the Director General, Corporations Directorate

[INDUSTRY CANADA LETTERHEAD]

                                                 Votre reference
le 14 juillet 1995

                                                 Notre reference
                                                    304758-0
Objet
DRAXIS HEALTH INC./
SANTE DRAXIS INC.

Vous trouverez ci-inclus le document emis dans l'affaire precitee.

Un avis de l'emission de documents en vertu de la LCSA sera publie dans le
Bulletin des societes canadiennes. Un avis de l'emission de documents en vertu
de la LCC sera publie dans le Bulletin des societes canadiennes et dans la
Gazette du Canada.

S'IL EST QUESTION D'UNE DENOMINATION SOCIALE OU D'UN CHANGEMENT DE DENOMINATION
SOCIALE, L'AVERTISSEMENT SUIVANT DOIT ETRE RESPECTE:

Cette denomination sociale est disponible en autant que les requerants assument
toute responsabilite de risque de confusion avec toutes denominations
commerciales et toutes marques de commerce existantes (y compris celles qui sont
citees dans le(s) rapport(s) de recherches de NUANS pertinent(s)). Cette
acceptation de responsabilite comprend l'obligation de changer la denomination
de la societe en une denomination differente advenant le cas ou des
representations sont faites etablissant qu'il y a une probabilite de confusion.
L'utilisation de tout nom octroye est sujette a toute loi de la juridiction ou
la societe exploite son entreprise.

/s/ Madeline Gigluie

pour le Directeur general, Direction generale des Corporations

[LOGO]

<PAGE>

[LOGO]

CERTIFICATE                                            CERTIFICAT
OF AMENDMENT                                           DE MODIFICATION

CANADA BUSINESS                                        LOI CANADIENNE SUR
CORPORATIONS ACT                                       LES SOCIETES PAR ACTIONS

<TABLE>
<CAPTION>

DRAXIS HEALTH INC./                                           304758-0
SANTE DRAXIS INC.

----------------------------------------------         ------------------------------------------------
Name of corporation-Denomination de la societe         Corporation number--Numero de la societe
<S>                                             <C>    <C>
I hereby certify that the articles of the              Je certifie que les statuts de la societe
above-named corporation were amended                   susmentionnee ont ete modifies:

(a) under section 13 of the CANADA BUSINESS     / /    a) en vertu de l'article 13 de la LOI
CORPORATIONS ACT in accordance with the                CANADIENNE SUR LES SOCIETES PAR ACTIONS,
attached notice;                                       conformement a l'avis ci-joint;

(b) under section 27 of the CANADA BUSINESS     / /    b) en vertu de l'article 27 de la LOI
CORPORATIONS ACT as set out in the attached            CANADIENNE SUR LES SOCIETES PAR ACTIONS, tel
articles of amendment designating a series             qu'il est indique dans les clauses modificatrices
of shares;                                             ci-jointes designant une serie d'actions;

(c) under section 179 of the CANADA BUSINESS    /X/    c) en vertu de l'article 179 de la LOI
CORPORATIONS ACT as set out in the attached            CANADIENNE SUR LES SOCIETES PAR ACTIONS, tel
articles of amendment;                                 qu'il est indique dans les clauses modificatrices
                                                       ci-jointes;

(d) under section 191 of the CANADA BUSINESS    / /    d) en vertu de l'article 191 de la LOI
CORPORATIONS ACT as set out in the attached            CANADIENNE SUR LES SOCIETES PAR ACTIONS, tel
articles of reorganization.                            qu'il est indique dans les clauses de
                                                       reorganisation ci-jointes.

/s/  [ILLEGIBLE]

Director - Directeur                                 JULY 14, 1995/LE 14 JUILLET 1995
                                                     Date of Amendment - Date de modification
</TABLE>

[LOGO]

<PAGE>

                                      FORM 4
                              ARTICLES OF AMENDMENT
                               (SECTION 27 OR 177)

                                     FORMULE 4
                             CLAUSES MODIFICATRICES
                              (ARTICLES 27 OU 177)

[LOGO]
Consumer and Corporate Affairs Canada
Canada Business Corporations Act

Consommation et Affaires commerciales Canada
Loi regissant les societes par actions de regime federal

-------------------------------------------------------------------------------
1. Name of corporation - Denomination de la societe
   DRAXIS HEALTH INC.
   SANTE DRAXIS INC.
-------------------------------------------------------------------------------
2. Corporation No. - No de la societe
   304-758-0
-------------------------------------------------------------------------------
3. The articles of the above-named corporation are amended as follows:

   Les statuts de la societe mentionnee ci-dessus sont modifies de la facon
   suivante:

(a) to create an unlimited number of employee participation shares ("EP
    Shares")

(b) to declare that the capital of the Corporation after giving effect to the
    foregoing consists of an unlimited number of common shares, an unlimited
    number of preferred shares and an unlimited number of EP Shares; and

(c) to provide that the rights, privileges, restrictions and conditions
    attaching to the EP Shares are set out in the annexed Exhibit I.

-------------------------------------------------------------------------------
DATE July 4, 1995

SIGNATURE /s/ J. Le Saux

TITLE-TITRE
VICE PRESIDENT, CORPORATE DEVELOPMENT, GENERAL COUNSEL AND SECRETARY
-------------------------------------------------------------------------------
FOR DEPARTMENTAL USE ONLY - A L'USAGE DU MINISTERE SEULE

FILED-DEPOSEE   JUIL 14 1995

<PAGE>

                                  EXHIBIT I

The rights, privileges, restrictions and conditions attaching to the EP
Shares are as follows:

(a)  SERIES:     The EP Shares may at any time or from time to time be issued
                 in one of more series. Subject to the following provisions,
                 the board of directors of the Corporation (the "Board") may
                 by resolution fix from time to time, before the issue thereof,
                 the number of shares in, and determine the designation, rights,
                 privileges, restrictions and conditions attaching to the shares
                 of, each series of EP Shares.

(b)  DIVIDENDS:  Each EP Share entitles the holder to receive cash dividends,
                 if any, as may from time to time be declared payable thereon,
                 at the same time as dividends, if any, are paid on Common
                 Shares of the Corporation, in an amount for each EP Share of a
                 particular series which is equal to the proportion of the
                 amount of the dividend declared on each Common Share that the
                 subscription price of such EP Share is of the Fair Market
                 Value of the Common Shares at the date of issuance of such
                 EP Share.

                 For the purpose hereof, the Fair Market Value of a Common
                 Share at a particular time means the average of the daily
                 high and low board lot trading prices on the Toronto Stock
                 Exchange ("TSE") on each of the five trading days immediately
                 preceding the date on which such value is to be determined.

(c)  CONVERSION: In the event of a proposal, order or resolution for the
                 liquidation, dissolution or winding-up of the Corporation,
                 whether voluntary or involuntary; or on the Automatic
                 Conversion Date (as defined below); or at the option of a
                 holder on a Conversion Date (as defined below) other than
                 the Automatic Conversion Date, the EP Shares will become
                 Common Shares, and the number of Common Shares a holder
                 receives on conversion is the number of Common Shares which
                 is determined by multiplying the number of EP Shares held, or
                 in the case of conversion on a Conversion Date other than the
                 Automatic Conversion Date, the number of EP Shares which the
                 holder elects to convert, by a fraction:

                 (i)  the numerator of which shall be the Employee
                      Participation Share Value (as defined below) of an EP
                      Share of a particular series as at the earlier of the
                      Automatic Conversion Date and a Conversion Date, as the
                      case may be; and

<PAGE>

                                      - 2 -

                 (ii) the denominator of which shall be the Fair Market Value
                      of a Common Share as at the earlier of the two dates
                      described in (i);

                 provided that no fractional Common Shares will be issued and
                 no payment will be made in respect of fractional Common Shares.

                 For the purposes hereof, the Automatic Conversion Date means
                 and refers to the date that is the fifth anniversary date of
                 the date of issue of the EP Shares of a particular series
                 and is the date on which all EP Shares of such series
                 will, to the extent not theretofore redeemed, be
                 converted into Common Shares. Conversion Date means any
                 Business Day following the date on which the EP Shares of
                 a particular series were issued, provided, however, that
                 no Conversion Date shall include a date other than the
                 Automatic Conversion Date unless on or prior to such date
                 the Minimum Vesting Period (as defined below) has expired
                 and the Fair Market Value of the Common Shares on such
                 date is at least twenty-five percent (25%) greater than
                 the Fair Market Value of the Common Shares on the issue
                 date of the EP Shares of such series. Business Day means
                 a day other than a Saturday, Sunday and statutory holiday
                 in the Province of Ontario, provided that the principal
                 offices of the Corporation in Mississauga, Ontario are
                 open for business on the particular day. Minimum Vesting
                 Period means, except as otherwise mutually agreed upon
                 by the holder and the Corporation, the period of time
                 commencing at the time of issuance of the EP Shares of a
                 particular series and ending on an anniversary date of
                 such issuance and occurring in the following percentages:

                    Year 1 - 20%
                    Year 2 - 20%
                    Year 3 - 20%
                    Year 4 - 40%

                 Employee Participation Share Value in respect of an EP Share
                 of a particular series at a particular time means the greater
                 of (i) the amount, if any, by which the Fair Market Value of
                 a Common Share as at that time exceeds the Fair Market Value
                 of a Common Share as at the date on which the first EP Share
                 of a particular series was issued; and (ii) the issue price.

                 Any right to conversion of an EP Share into a Common
                 Share on a Conversion Date other than the Automatic
                 Conversion Date shall be exercised by notice in writing
                 given by the holder to the Corporation.

<PAGE>

                                      - 3 -

(d)  NO VOTE:    No EP Share entitle the holder to vote at meetings of
                 shareholders of the Corporation except in special
                 circumstances prescribed under the CANADA BUSINESS
                 CORPORATIONS ACT as now enacted or as the same may from
                 time to time be amended, re-enacted or replaced.

(e)  TRANSFERABILITY:   No EP Share is transferable except to a holder's
                        registered retirement savings plan (as defined
                        pursuant to the INCOME TAX ACT (Canada) or by reason
                        of testate or intestate succession.

(f)  CANCELLATION: The Corporation may purchase an EP Share at any time for
                   cancellation at its issue price with no notice.

<PAGE>

                                      FORM 4
                              ARTICLES OF AMENDMENT
                               (SECTION 27 OR 177)

                                     FORMULE 4
                             CLAUSES MODIFICATRICES
                              (ARTICLES 27 OU 177)

[LOGO]
Consumer and Corporate Affairs Canada
Canada Business Corporations Act

Consommation et Affaires commerciales Canada
Loi regissant les societes par actions de regime federal

-------------------------------------------------------------------------------
1. Name of corporation - Denomination de la societe
   DRAXIS HEALTH INC.
   SANTE DRAXIS INC.
-------------------------------------------------------------------------------
2. Corporation No. - No de la societe
   293391-8
-------------------------------------------------------------------------------
3. The articles of the above-named corporation are amended as follows:

   Les statuts de la societe mentionnee ci-dessus sont modifies de la facon
   suivante:

(a) to create an unlimited number of employee participation shares ("EP
    Shares")

(b) to declare that the capital of the Corporation after giving effect to the
    foregoing consists of an unlimited number of common shares, an unlimited
    number of preferred shares and an unlimited number of EP Shares; and

(c) to provide that the rights, privileges, restrictions and conditions
    attaching to the EP Shares are set out in the annexed Exhibit I.

-------------------------------------------------------------------------------
DATE July 4, 1995

SIGNATURE /s/ J. Le Saux

TITLE-TITRE
VICE PRESIDENT, CORPORATE DEVELOPMENT, GENERAL COUNSEL AND SECRETARY
-------------------------------------------------------------------------------
FOR DEPARTMENTAL USE ONLY - AL'USAGE DU MINISTERE SEULE

FILED-DEPOSEE

<PAGE>

                                  EXHIBIT I

The rights, privileges, restrictions and conditions attaching to the EP
Shares are as follows:

(a)  SERIES:     The EP Shares may at any time or from time to time be issued
                 in one of more series. Subject to the following provisions,
                 the board of directors of the Corporation (the "Board") may
                 by resolution fix from time to time, before the issue thereof,
                 the number of shares in, and determine the designation, rights,
                 privileges, restrictions and conditions attaching to the shares
                 of, each series of EP Shares.

(b)  DIVIDENDS:  Each EP Share entitles the holder to receive cash dividends,
                 if any, as may from time to time be declared payable thereon,
                 at the same time as dividends, if any, are paid on Common
                 Shares of the Corporation, in an amount for each EP Share of a
                 particular series which is equal to the proportion of the
                 amount of the dividend declared on each Common Share that the
                 subscription price of such EP Share is of the Fair Market
                 Value of the Common Shares at the date of issuance of such
                 EP Share.

                 For the purpose hereof, the Fair Market Value of a Common
                 Share at a particular time means the average of the daily
                 high and low board lot trading prices on the Toronto Stock
                 Exchange ("TSE") on each of the five trading days immediately
                 preceding the date on which such value is to be determined.

(c)  CONVERSION: In the event of a proposal, order or resolution for the
                 liquidation, dissolution or winding-up of the Corporation,
                 whether voluntary or involuntary; or on the Automatic
                 Conversion date (as defined below); or at the option of a
                 holder on a Conversion Date (as defined below) other than
                 the Automatic Conversion Date, the EP Shares will become
                 Common Shares, and the number of Common Shares a holder
                 receives on conversion is the number of Common Shares which
                 is determined by multiplying the number of EP Shares held, or
                 in the case of conversion on a Conversion Date other than the
                 Automatic Conversion date, the number of EP Shares which the
                 holder elects to convert, by a fraction:

                 (i)  the numerator of which shall be the Employee
                      Participation Share Value (as defined below) of an EP
                      Share of a particular series as at the earlier of the
                      Automatic Conversion Date and a Conversion Date, as the
                      case may be; and

<PAGE>

                                      - 2 -

                 (ii) the denominator of which shall be the Fair Market Value
                      of a Common Share as at the earlier of the two dates
                      described in (i);

                 provided that no fractional Common Shares will be issued and
                 no payment will be made in respect of fractional Common Shares.

                 For the purposed hereof, the Automatic Conversion date means
                 and refers to the date that is the fifth anniversary date of
                 the date of issue of the EP Shares of a particular series
                 and is the date on which all EP Shares of such series
                 will, to the extent not theretofore redeemed, be
                 converted into Common Shares. Conversion date means any
                 Business Day following the date on which the EP Shares of
                 a particular series were issued, provided, however, that
                 no Conversion Date shall include a date other than the
                 Automatic Conversion Date unless on or prior to such date
                 the Minimum Vesting Period (as defined below) has expired
                 and the Fair Market Value of the Common Shares on such
                 date is at least twenty-five percent (25%) greater than
                 the Fair Market Value of the Common Shares on the issue
                 date of the EP Shares of such series. Business Day means
                 a day other than a Saturday, Sunday and statutory holiday
                 in the Province of Ontario, provided that the principal
                 offices of the Corporation in Mississauga, Ontario are
                 open of business on the particular day. Minimum Vesting
                 Period means, except as otherwise mutually agreed upon
                 by the holder and the Corporation, the period of time
                 commencing at the time of issuance of the EP Shares of a
                 particular series and ending on an anniversary date of
                 such issuance and occurring in the following percentages:

                    Year 1 - 20%
                    Year 2 - 20%
                    Year 3 - 20%
                    Year 4 - 40%

                 Employee Participation Share Value in respect of an EP Share
                 of a particular series at a particular time means the greater
                 of (i) the amount, if any, by which the Fair Market Value of
                 a Common Share as at that time exceeds the Fair Market Value
                 of a Common Share as at the date on which the first EP Share
                 of a particular series was issued; and (ii) the issue price.

                 Any right to conversion of an EP Share into a Common
                 Share on a Conversion Date other than the Automatic
                 Conversion Date shall be exercised by notice in writing
                 given by the holder to the Corporation.

<PAGE>

                                      - 3 -

(d)  NO VOTE:    No EP Share entitle the holder to vote at meetings of
                 shareholders of the Corporation except in special
                 circumstances prescribed under the CANADA BUSINESS
                 CORPORATIONS ACT as now enacted or as the same may from
                 time to time be amended, re-enacted or replaced.

(e)  TRANSFERABILITY:   No EP Share is transferable except to a holder's
                        registered retirement savings plan (as defined
                        pursuant to the INCOME TAX ACT (Canada) or by reason
                        of testate or intestate succession.

(f)  CANCELLATION: The Corporation may purchase an EP Share at any time for
                   cancellation at its issue price with no notice.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00027-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00027-of-00352.parquet"}]]