Document:

2011 Employee Stock Purchase Plan

 Exhibit 10.4 
 HORIZON PHARMA, INC. 
 2011
EMPLOYEE STOCK PURCHASE PLAN 
 ADOPTED
BY THE BOARD OF DIRECTORS: MARCH 31, 2011 
 APPROVED BY THE STOCKHOLDERS:             , 2011 

 

	1.	GENERAL. 

(a) The purpose of the Plan is to provide a means by which Eligible Employees of the Company and certain designated Related
Corporations may be given an opportunity to purchase shares of Common Stock. The Plan is intended to permit the Company to grant a series of Purchase Rights to Eligible Employees under an Employee Stock Purchase Plan. 

(b) The Company, by means of the Plan, seeks to retain the services of such Employees, to secure and retain the services of new
Employees and to provide incentives for such persons to exert maximum efforts for the success of the Company and its Related Corporations. 
  

	2.	ADMINISTRATION. 

 (a) The Board shall administer the Plan unless and until the Board delegates administration of the Plan to a Committee or Committees, as provided in Section 2(c). 

(b) The Board shall have the power, subject to, and within the limitations of, the express provisions of the Plan: 

(i) To determine how and when Purchase Rights to purchase shares of Common Stock shall be granted and the provisions of each
Offering of such Purchase Rights (which need not be identical). 
 (ii) To designate from time to time which Related
Corporations of the Company shall be eligible to participate in the Plan. 
 (iii) To construe and interpret the Plan and
Purchase Rights, and to establish, amend and revoke rules and regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan, in a manner and to the extent it shall deem
necessary or expedient to make the Plan fully effective. 
 (iv) To settle all controversies regarding the Plan and
Purchase Rights granted under it. 
 (v) To suspend or terminate the Plan at any time as provided in Section 12.

 (vi) To amend the Plan at any time as provided in Section 12. 

  
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 (vii) Generally, to exercise such powers and to perform such acts as it deems
necessary or expedient to promote the best interests of the Company and its Related Corporations and to carry out the intent that the Plan be treated as an Employee Stock Purchase Plan. 

(viii) To adopt such procedures and sub-plans as are necessary or appropriate to permit participation in the Plan by Employees who
are foreign nationals or employed outside the United States. 
 (c) The Board may delegate some or all of the
administration of the Plan to a Committee or Committees. If administration is delegated to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers theretofore possessed by the Board that have been
delegated to the Committee, including the power to delegate to a subcommittee any of the administrative powers the Committee is authorized to exercise (and references in this Plan to the Board shall thereafter be to the Committee or subcommittee),
subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. The Board may retain the authority to concurrently administer the Plan with the Committee and may, at any
time, revest in the Board some or all of the powers previously delegated. Whether or not the Board has delegated administration of the Plan to a Committee, the Board shall have the final power to determine all questions of policy and expediency that
may arise in the administration of the Plan. 
 (d) All determinations, interpretations and constructions made by the
Board in good faith shall not be subject to review by any person and shall be final, binding and conclusive on all persons. 
  

	3.	SHARES OF COMMON STOCK SUBJECT TO THE PLAN.

 (a) Subject to the provisions of Section 11(a) relating to Capitalization Adjustments, the
shares of Common Stock that may be sold pursuant to Purchase Rights shall not exceed in the aggregate one million one hundred thousand (1,100,000) shares of Common Stock. In addition, the number of shares of Common Stock available for issuance under
the Plan shall automatically increase on January 1st of each year, commencing in 2012 and ending on (and including) January 1, 2021, in an amount equal to the lesser of (i) four percent (4%) of the total number of shares of
Common Stock outstanding on December 31st of the preceding calendar year, or (ii) two million five hundred thousand (2,500,000) shares of Common Stock. Notwithstanding the foregoing, the Board may act prior to the first day of any calendar
year, to provide that there shall be no increase in the share reserve for such calendar year or that the increase in the share reserve for such calendar year shall be a lesser number of shares of Common Stock than would otherwise occur pursuant to
the preceding sentence. 
 (b) If any Purchase Right granted under the Plan shall for any reason terminate without having
been exercised, the shares of Common Stock not purchased under such Purchase Right shall again become available for issuance under the Plan. 
 (c) The stock purchasable under the Plan shall be shares of authorized but unissued or reacquired Common Stock, including shares repurchased by the Company on the open market. 

  
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	4.	GRANT OF PURCHASE RIGHTS; OFFERING. 

(a) The Board may from time to time grant or provide for the grant of Purchase Rights to purchase shares of Common Stock under the
Plan to Eligible Employees in an Offering (consisting of one or more Purchase Periods) on an Offering Date or Offering Dates selected by the Board. Each Offering shall be in such form and shall contain such terms and conditions as the Board shall
deem appropriate, which shall comply with the requirement of Section 423(b)(5) of the Code that all Employees granted Purchase Rights shall have the same rights and privileges. The terms and conditions of an Offering shall be incorporated by
reference into the Plan and treated as part of the Plan. The provisions of separate Offerings need not be identical, but each Offering shall include (through incorporation of the provisions of this Plan by reference in the document comprising the
Offering or otherwise) the period during which the Offering shall be effective, which period shall not exceed twenty-seven (27) months beginning with the Offering Date, and the substance of the provisions contained in Sections 5 through 8,
inclusive. 
 (b) If a Participant has more than one Purchase Right outstanding under the Plan, unless he or she
otherwise indicates in agreements or notices delivered hereunder: (i) each agreement or notice delivered by that Participant shall be deemed to apply to all of his or her Purchase Rights under the Plan, and (ii) a Purchase Right with a
lower exercise price (or an earlier-granted Purchase Right, if different Purchase Rights have identical exercise prices) shall be exercised to the fullest possible extent before a Purchase Right with a higher exercise price (or a later-granted
Purchase Right if different Purchase Rights have identical exercise prices) shall be exercised. 
 (c) The Board shall
have the discretion to structure an Offering so that if the Fair Market Value of the shares of Common Stock on the first day of a new Purchase Period within that Offering is less than or equal to the Fair Market Value of the shares of Common Stock
on the Offering Date, then (i) that Offering shall terminate immediately, and (ii) the Participants in such terminated Offering shall be automatically enrolled in a new Offering beginning on the first day of such new Purchase Period.

  

	5.	ELIGIBILITY. 

 (a) Purchase Rights may be granted only to Employees of the Company or, as the Board may designate as provided in Section 2(b), to Employees of a Related Corporation. Except as provided in
Section 5(b), an Employee shall not be eligible to be granted Purchase Rights under the Plan unless, on the Offering Date, such Employee has been in the employ of the Company or the Related Corporation, as the case may be, for such continuous
period preceding such Offering Date as the Board may require, but in no event shall the required period of continuous employment be greater than two (2) years. In addition, the Board may provide that no Employee shall be eligible to be granted
Purchase Rights under the Plan unless, on the Offering Date, such Employee’s customary employment with the Company or the Related Corporation is more than twenty (20) hours per week and more than five (5) months per calendar year or
such other criteria as the Board may determine consistent with Section 423 of the Code. 
 (b) The Board may provide
that each person who, during the course of an Offering, first becomes an Eligible Employee shall, on a date or dates specified in the Offering which 

  
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coincides with the day on which such person becomes an Eligible Employee or which occurs thereafter, receive a Purchase Right under that Offering, which Purchase Right shall thereafter be deemed
to be a part of that Offering. Such Purchase Right shall have the same characteristics as any Purchase Rights originally granted under that Offering, as described herein, except that: 

(i) the date on which such Purchase Right is granted shall be the “Offering Date” of such Purchase Right for all
purposes, including determination of the exercise price of such Purchase Right; 
 (ii) the period of the Offering with
respect to such Purchase Right shall begin on its Offering Date and end coincident with the end of such Offering; and 

(iii) the Board may provide that if such person first becomes an Eligible Employee within a specified period of time before the
end of the Offering, he or she shall not receive any Purchase Right under that Offering. 
 (c) No Employee shall be
eligible for the grant of any Purchase Rights under the Plan if, immediately after any such Purchase Rights are granted, such Employee owns stock possessing five percent (5%) or more of the total combined voting power or value of all classes of
stock of the Company or of any Related Corporation. For purposes of this Section 5(c), the rules of Section 424(d) of the Code shall apply in determining the stock ownership of any Employee, and stock which such Employee may purchase under
all outstanding Purchase Rights and options shall be treated as stock owned by such Employee. 
 (d) As specified by
Section 423(b)(8) of the Code, an Eligible Employee may be granted Purchase Rights under the Plan only if such Purchase Rights, together with any other rights granted under all Employee Stock Purchase Plans of the Company and any Related
Corporations, do not permit such Eligible Employee’s rights to purchase stock of the Company or any Related Corporation to accrue at a rate which exceeds twenty five thousand dollars ($25,000) of Fair Market Value of such stock (determined at
the time such rights are granted, and which, with respect to the Plan, shall be determined as of their respective Offering Dates) for each calendar year in which such rights are outstanding at any time. 

(e) Officers of the Company and any designated Related Corporation, if they are otherwise Eligible Employees, shall be eligible to
participate in Offerings under the Plan. Notwithstanding the foregoing, the Board may provide in an Offering that Employees who are highly compensated Employees within the meaning of Section 423(b)(4)(D) of the Code shall not be eligible to
participate. 
  

	6.	PURCHASE RIGHTS; PURCHASE PRICE. 

(a) On each Offering Date, each Eligible Employee, pursuant to an Offering made under the Plan, shall be granted a Purchase Right
to purchase up to that number of shares of Common Stock purchasable either with a percentage or with a maximum dollar amount, as designated by the Board, but in either case not exceeding fifteen percent (15%) of such Employee’s earnings
(as defined by the Board in each Offering) during the period that begins on the Offering Date (or such later date as the Board determines for a particular Offering) and ends on the date stated in the Offering, which date shall be no later than the
end of the Offering. 

  
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 (b) The Board shall establish one (1) or more Purchase Dates during an Offering
as of which Purchase Rights granted pursuant to that Offering shall be exercised and purchases of shares of Common Stock shall be carried out in accordance with such Offering. 
 (c) In connection with each Offering made under the Plan, the Board may specify a maximum number of shares of Common Stock that may be purchased by any Participant on any Purchase Date during such
Offering. In connection with each Offering made under the Plan, the Board may specify a maximum aggregate number of shares of Common Stock that may be purchased by all Participants pursuant to such Offering. In addition, in connection with each
Offering that contains more than one Purchase Date, the Board may specify a maximum aggregate number of shares of Common Stock that may be purchased by all Participants on any Purchase Date under the Offering. If the aggregate purchase of shares of
Common Stock issuable upon exercise of Purchase Rights granted under the Offering would exceed any such maximum aggregate number, then, in the absence of any Board action otherwise, a pro rata allocation of the shares of Common Stock available shall
be made in as nearly a uniform manner as shall be practicable and equitable. 
 (d) The purchase price of shares of
Common Stock acquired pursuant to Purchase Rights shall be not less than the lesser of: 
 (i) an amount equal to
eighty-five percent (85%) of the Fair Market Value of the shares of Common Stock on the Offering Date; or 
 (ii) an
amount equal to eighty-five percent (85%) of the Fair Market Value of the shares of Common Stock on the applicable Purchase Date. 
  

	7.	PARTICIPATION; WITHDRAWAL; TERMINATION. 

(a) A Participant may elect to authorize payroll deductions pursuant to an Offering under the Plan by completing and delivering to
the Company, within the time specified in the Offering, an enrollment form (in such form as the Company may provide). Each such enrollment form shall authorize an amount of Contributions expressed as a percentage of the submitting Participant’s
earnings (as defined in each Offering) during the Offering (not to exceed the maximum percentage specified by the Board). Each Participant’s Contributions shall be credited to a bookkeeping account for such Participant under the Plan and shall
be deposited with the general funds of the Company except where applicable law requires that Contributions be deposited with a third party. To the extent provided in the Offering, a Participant may begin such Contributions after the beginning of the
Offering. To the extent provided in the Offering, a Participant may thereafter reduce (including to zero) or increase his or her Contributions. To the extent specifically provided in the Offering, in addition to making Contributions by payroll
deductions, a Participant may make Contributions through the payment by cash or check prior to each Purchase Date of the Offering. 
 (b) During an Offering, a Participant may cease making Contributions and withdraw from the Offering by delivering to the Company a notice of withdrawal in such form as the Company may provide. Such
withdrawal may be elected at any time prior to the end of the Offering, except as provided otherwise in the Offering. Upon such withdrawal from the Offering 

  
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by a Participant, the Company shall distribute to such Participant all of his or her accumulated Contributions (reduced to the extent, if any, such Contributions have been used to acquire shares
of Common Stock for the Participant) under the Offering, and such Participant’s Purchase Right in that Offering shall thereupon terminate. A Participant’s withdrawal from an Offering shall have no effect upon such Participant’s
eligibility to participate in any other Offerings under the Plan, but such Participant shall be required to deliver a new enrollment form in order to participate in subsequent Offerings. 

(c) Purchase Rights granted pursuant to any Offering under the Plan shall terminate immediately upon a Participant ceasing to be
an Employee for any reason or for no reason (subject to any post-employment participation period required by law) or other lack of eligibility. The Company shall distribute to such terminated or otherwise ineligible Employee all of his or her
accumulated Contributions (reduced to the extent, if any, such Contributions have been used to acquire shares of Common Stock for the terminated or otherwise ineligible Employee) under the Offering. 

(d) Purchase Rights shall not be transferable by a Participant except by will, the laws of descent and distribution, or by a
beneficiary designation as provided in Section 10. During a Participant’s lifetime, Purchase Rights shall be exercisable only by such Participant. 
 (e) Unless otherwise specified in an Offering, the Company shall have no obligation to pay interest on Contributions. 

 

	8.	EXERCISE OF PURCHASE RIGHTS. 

(a) On each Purchase Date during an Offering, each Participant’s accumulated Contributions shall be applied to the purchase of
shares of Common Stock up to the maximum number of shares of Common Stock permitted pursuant to the terms of the Plan and the applicable Offering, at the purchase price specified in the Offering. No fractional shares shall be issued upon the
exercise of Purchase Rights unless specifically provided for in the Offering. 
 (b) If any amount of accumulated
Contributions remains in a Participant’s account after the purchase of shares of Common Stock and such remaining amount is less than the amount required to purchase one share of Common Stock on the final Purchase Date of an Offering, then such
remaining amount shall be held in such Participant’s account for the purchase of shares of Common Stock under the next Offering under the Plan, unless such Participant withdraws from such next Offering, as provided in Section 7(b), or is
not eligible to participate in such Offering, as provided in Section 5, in which case such amount shall be distributed to such Participant after the final Purchase Date, without interest. If the amount of Contributions remaining in a
Participant’s account after the purchase of shares of Common Stock is at least equal to the amount required to purchase one (1) whole share of Common Stock on the final Purchase Date of the Offering, then such remaining amount shall be
distributed in full to such Participant at the end of the Offering without interest. 
 (c) No Purchase Rights may be
exercised to any extent unless the shares of Common Stock to be issued upon such exercise under the Plan are covered by an effective registration statement pursuant to the Securities Act and the Plan is in material compliance with all

  
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applicable federal, state, foreign and other securities and other laws applicable to the Plan. If on a Purchase Date during any Offering hereunder the shares of Common Stock are not so registered
or the Plan is not in such compliance, no Purchase Rights or any Offering shall be exercised on such Purchase Date, and the Purchase Date shall be delayed until the shares of Common Stock are subject to such an effective registration statement and
the Plan is in such compliance, except that the Purchase Date shall not be delayed more than twelve (12) months and the Purchase Date shall in no event be more than twenty-seven (27) months from the Offering Date. If, on the Purchase Date
under any Offering hereunder, as delayed to the maximum extent permissible, the shares of Common Stock are not registered and the Plan is not in such compliance, no Purchase Rights or any Offering shall be exercised and all Contributions accumulated
during the Offering (reduced to the extent, if any, such Contributions have been used to acquire shares of Common Stock) shall be distributed to the Participants without interest. 

 

	9.	COVENANTS OF THE COMPANY. 

The Company shall seek to obtain from each federal, state, foreign or other regulatory commission or agency having jurisdiction over the
Plan such authority as may be required to issue and sell shares of Common Stock upon exercise of the Purchase Rights. If, after commercially reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency the
authority that counsel for the Company deems necessary for the lawful issuance and sale of Common Stock under the Plan, the Company shall be relieved from any liability for failure to issue and sell Common Stock upon exercise of such Purchase Rights
unless and until such authority is obtained. 
  

	10.	DESIGNATION OF BENEFICIARY. 

 (a) A Participant may file a written designation of a beneficiary who is to receive any shares of Common Stock and/or cash, if any, from the Participant’s account under the Plan in the event
of such Participant’s death subsequent to the end of an Offering but prior to delivery to the Participant of such shares of Common Stock or cash. In addition, a Participant may file a written designation of a beneficiary who is to receive any
cash from the Participant’s account under the Plan in the event of such Participant’s death during an Offering. Any such designation shall be on a form provided by or otherwise acceptable to the Company. 

(b) The Participant may change such designation of beneficiary at any time by written notice to the Company. In the event of the
death of a Participant and in the absence of a beneficiary validly designated under the Plan who is living at the time of such Participant’s death, the Company shall deliver such shares of Common Stock and/or cash to the executor or
administrator of the estate of the Participant, or if no such executor or administrator has been appointed (to the knowledge of the Company), the Company, in its sole discretion, may deliver such shares of Common Stock and/or cash to the spouse or
to any one or more dependents or relatives of the Participant, or if no spouse, dependent or relative is known to the Company, then to such other person as the Company may designate. 

  
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	11.	ADJUSTMENTS UPON CHANGES IN COMMON STOCK; CORPORATE
TRANSACTIONS. 

 (a) In the event of a Capitalization Adjustment, the Board shall
appropriately and proportionately adjust: (i) the class(es) and maximum number of securities subject to the Plan pursuant to Section 3(a), (ii) the class(es) and maximum number of securities by which the share reserve is to increase
automatically each year pursuant to Section 3(a), (iii) the class(es) and number of securities subject to, and the purchase price applicable to outstanding Offerings and Purchase Rights, and (iv) the class(es) and number of securities
imposed by purchase limits under each ongoing Offering. The Board shall make such adjustments, and its determination shall be final, binding and conclusive. 
 (b) In the event of a Corporate Transaction, then: (i) any surviving corporation or acquiring corporation (or the surviving or acquiring corporation’s parent company) may assume or
continue Purchase Rights outstanding under the Plan or may substitute similar rights (including a right to acquire the same consideration paid to the stockholders in the Corporate Transaction) for those outstanding under the Plan, or (ii) if
any surviving or acquiring corporation (or its parent company) does not assume or continue such Purchase Rights or does not substitute similar rights for Purchase Rights outstanding under the Plan, then the Participants’ accumulated
Contributions shall be used to purchase shares of Common Stock within ten (10) business days prior to the Corporate Transaction under any ongoing Offerings, and the Participants’ Purchase Rights under the ongoing Offerings shall terminate
immediately after such purchase. 
  

	12.	AMENDMENT, TERMINATION OR SUSPENSION OF THE PLAN.

 (i) The Board may amend the Plan at any time in any respect the Board deems necessary or advisable.
However, except as provided in Section 11(a) relating to Capitalization Adjustments, stockholder approval shall be required for any amendment of the Plan for which stockholder approval is required by applicable law or listing requirements,
including any amendment that either (i) materially increases the number of shares of Common Stock available for issuance under the Plan, (ii) materially expands the class of individuals eligible to become Participants and receive Purchase
Rights under the Plan, (iii) materially increases the benefits accruing to Participants under the Plan or materially reduces the price at which shares of Common Stock may be purchased under the Plan, (iv) materially extends the term of the
Plan, or (v) expands the types of awards available for issuance under the Plan, but in each of (i) through (v) above only to the extent stockholder approval is required by applicable law or listing requirements. 

(b) The Board may suspend or terminate the Plan at any time. No Purchase Rights may be granted under the Plan while the Plan is
suspended or after it is terminated. 
 (c) Any benefits, privileges, entitlements and obligations under any outstanding
Purchase Rights granted before an amendment, suspension or termination of the Plan shall not be impaired by any such amendment, suspension or termination except (i) with the consent of the person to whom such Purchase Rights were granted,
(ii) as necessary to comply with any laws, listing requirements, or governmental regulations (including, without limitation, the provisions of Section 423 of the Code and the regulations and other interpretive guidance issued thereunder

  
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relating to Employee Stock Purchase Plans) including without limitation any such regulations or other guidance that may be issued or amended after the Effective Date, or (iii) as necessary
to obtain or maintain favorable tax, listing, or regulatory treatment. 
  

	13.	EFFECTIVE DATE OF PLAN. 

The Plan shall become effective on the IPO Date, but no Purchase Rights shall be exercised unless and until the Plan has been approved by
the stockholders of the Company, which approval shall be within twelve (12) months before or after the date the Plan is adopted by the Board. 
  

	14.	MISCELLANEOUS PROVISIONS. 

 (a) Proceeds from the sale of shares of Common Stock pursuant to Purchase Rights shall constitute general funds of the Company. 

(b) A Participant shall not be deemed to be the holder of, or to have any of the rights of a holder with respect to, shares of
Common Stock subject to Purchase Rights unless and until the Participant’s shares of Common Stock acquired upon exercise of Purchase Rights are recorded in the books of the Company (or its transfer agent). 

(c) The Plan and Offering do not constitute an employment contract. Nothing in the Plan or in the Offering shall in any way alter
the at will nature of a Participant’s employment or be deemed to create in any way whatsoever any obligation on the part of any Participant to continue in the employ of the Company or a Related Corporation, or on the part of the Company or a
Related Corporation to continue the employment of a Participant. 
 (d) The provisions of the Plan shall be governed by
the laws of the State of California without resort to that state’s conflicts of laws rules. 
  

	15.	DEFINITIONS. 

 As used in the Plan, the following definitions shall apply to the capitalized terms indicated below: 
 (a) “Board” means the Board of Directors of the Company. 
 (b) “Capitalization Adjustment” means any change that is made in, or other events that occur with respect to, the Common Stock subject to the
Plan or subject to any Purchase Right after the Effective Date without the receipt of consideration by the Company (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than
cash, stock split, liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other similar transaction). Notwithstanding the foregoing, the conversion of any convertible securities of the Company shall not be
treated as a Capitalization Adjustment. 
 (c) “Code” means the Internal Revenue Code of
1986, as amended. 

  
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 (d) “Committee” means a committee of one (1) or more
members of the Board to whom authority has been delegated by the Board in accordance with Section 2(c). 
 (e)
“Common Stock” means the common stock of the Company. 
 (f)
“Company” means Horizon Pharma, Inc., a Delaware corporation. 
 (g)
“Contributions” means the payroll deductions and other additional payments specifically provided for in the Offering, that a Participant contributes to fund the exercise of a Purchase Right. A Participant may make
additional payments into his or her account, if specifically provided for in the Offering, and then only if the Participant has not already had the maximum permitted amount withheld during the Offering through payroll deductions. 

(h) “Corporate Transaction” means the occurrence, in a single transaction or in a series of related
transactions, of any one or more of the following events: 
 (i) the consummation of a sale or other disposition of all
or substantially all, as determined by the Board in its sole discretion, of the consolidated assets of the Company and its Subsidiaries; 
 (ii) the consummation of a sale or other disposition of at least ninety percent (90%) of the outstanding securities of the Company; 

(iii) the consummation of a merger, consolidation or similar transaction following which the Company is not the surviving
corporation; or 
 (iv) the consummation of a merger, consolidation or similar transaction following which the Company is
the surviving corporation but the shares of Common Stock outstanding immediately preceding the merger, consolidation or similar transaction are converted or exchanged by virtue of the merger, consolidation or similar transaction into other property,
whether in the form of securities, cash or otherwise. 
 (i) “Director” means a member of the
Board. 
 (j) “Eligible Employee” means an Employee who meets the requirements set forth in the
Offering for eligibility to participate in the Offering, provided that such Employee also meets the requirements for eligibility to participate set forth in the Plan. 
 (k) “Employee” means any person, including Officers and Directors, who is employed for purposes of Section 423(b)(4) of the Code by the Company or a Related
Corporation. However, service solely as a Director, or payment of a fee for such services, shall not cause a Director to be considered an “Employee” for purposes of the Plan. 

(l) “Employee Stock Purchase Plan” means a plan that grants Purchase Rights intended to be options issued
under an “employee stock purchase plan,” as that term is defined in Section 423(b) of the Code. 
 (m)
“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

  
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 (n) “Fair Market Value” means, as of any date, the value of
the Common Stock determined as follows: 
 (i) If the Common Stock is listed on any established stock exchange or traded
on the NASDAQ Global Market or the NASDAQ Global Select Market, the Fair Market Value of a share of Common Stock, unless otherwise determined by the Board, shall be the closing sales price for such stock as quoted on such exchange or market (or the
exchange or market with the greatest volume of trading in the Common Stock) on the last market trading day prior to the day of determination, as reported in a source the Board deems reliable. Unless otherwise provided by the Board, if there is no
closing sales price for the Common Stock on the last market trading day prior to the day of determination, then the Fair Market Value shall be the closing selling price (or closing bid if no sales were reported) on the last preceding date for which
such quotation exists. 
 (ii) In the absence of such markets for the Common Stock, the Fair Market Value shall be
determined by the Board in good faith. 
 (iii) Notwithstanding the foregoing, for any Offering that commences on the IPO
Date, the Fair Market Value of the shares of Common Stock at the time when the Offering commences shall be the price per share at which shares are first sold to the public in the Company’s initial public offering as specified in the final
prospectus for that initial public offering. 
 (o) “IPO Date” means the date of the underwriting
agreement between the Company and the underwriter(s) managing the initial public offering of the Common Stock, pursuant to which the Common Stock is priced for the initial public offering. 

(p) “Offering” means the grant of Purchase Rights to purchase shares of Common Stock under the Plan to
Eligible Employees. 
 (q) “Offering Date” means a date selected by the Board for an Offering to
commence. 
 (r) “Officer” means a person who is an officer of the Company within the meaning of
Section 16 of the Exchange Act and the rules and regulations promulgated thereunder. 
 (s)
“Participant” means an Eligible Employee who holds an outstanding Purchase Right granted pursuant to the Plan. 
 (t) “Plan” means this Horizon Pharma, Inc. 2011 Employee Stock Purchase Plan. 
 (u) “Purchase Date” means one or more dates during an Offering established by the Board on which Purchase Rights shall be exercised and as of which purchases of shares of
Common Stock shall be carried out in accordance with such Offering. 
 (v) “Purchase Period”
means a period of time specified within an Offering beginning on the Offering Date or on the next day following a Purchase Date within an Offering and ending on a Purchase Date. An Offering may consist of one or more Purchase Periods. 

  
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 (w) “Purchase Right” means an option to purchase shares of
Common Stock granted pursuant to the Plan. 
 (x) “Related Corporation” means any “parent
corporation” or “subsidiary corporation” of the Company whether now or subsequently established, as those terms are defined in Sections 424(e) and (f), respectively, of the Code. 

(y) “Securities Act” means the Securities Act of 1933, as amended. 

(z) “Trading Day” means any day on which the exchange(s) or market(s) on which shares of Common Stock are
listed, including the Nasdaq Global Select Market, the Nasdaq Global Market, or the Nasdaq Capital Market, is open for trading. 

  
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 HORIZON PHARMA, INC. 

2011 EMPLOYEE STOCK PURCHASE PLAN 

OFFERING DOCUMENT 
 ADOPTED BY THE BOARD OF DIRECTORS: MARCH 31, 2011 

In this document, capitalized terms not otherwise defined shall have the same definitions of such terms as in the Horizon Pharma, Inc.
2011 Employee Stock Purchase Plan. 
  

	1.	GRANT; OFFERING DATE. 

 (a) The Board hereby authorizes a series of Offerings pursuant to the terms of this Offering document. 
 (b) The first Offering hereunder (the “Initial Offering”) shall begin on the IPO Date and shall end on June 1, 2013 approximately twenty four (24) months following
the commencement of the Initial Offering, unless terminated earlier as provided below. The Initial Offering shall consist of four (4) Purchase Periods, approximately six (6) months in length ending on or about June 1 and
December 1 each year with the first Purchase Period ending on December 1, 2011, the second Purchase Period ending on June 1, 2012, the third Purchase Period ending on December 1, 2012, and the fourth Purchase Period ending on
June 1, 2013. 
 (c) After the Initial Offering commences, a new Offering shall thereafter automatically begin every
six (6) months thereafter over the term of the Plan and shall be approximately twenty four (24) months in duration. Offerings shall be concurrent, but an Eligible Employee may enroll in only one Offering at a time. Each Offering shall
consist of four (4) Purchase Periods approximately six (6) months in length ending on or about June 1 and December 1 each year. Except as provided below, a Purchase Date is the last day of a Purchase Period or of an Offering, as
the case may be. 
 (d) Notwithstanding the foregoing: (i) if any Offering Date falls on a day that is not a Trading
Day, then such Offering Date shall instead fall on the next subsequent Trading Day, and (ii) if any Purchase Date falls on a day that is not a Trading Day, then such Purchase Date shall instead fall on the immediately preceding Trading Day.

 (e) Prior to the commencement of any Offering, the Board may change any or all terms of such Offering and any
subsequent Offerings. The granting of Purchase Rights pursuant to each Offering hereunder shall occur on each respective Offering Date unless prior to such date (i) the Board determines that such Offering shall not occur, or (ii) no shares
of Common Stock remain available for issuance under the Plan in connection with the Offering. 
 (f) Notwithstanding
anything in this Section 1 to the contrary, if the Fair Market Value of a share of Common Stock on any Purchase Date during an Offering is less than or equal to the Fair Market Value of a share of Common Stock on the Offering Date for that
Offering, then that Offering shall terminate immediately following the purchase of shares of Common Stock on such Purchase Date. Participants in the terminated Offering automatically shall be enrolled in the Offering that commences immediately after
such Purchase Date. 

  
 1. 

	2.	ELIGIBLE EMPLOYEES. 

 (a) Each Eligible Employee, who is either (i) an employee of the Company; (ii) an employee of a Related Corporation incorporated in the United States; or (iii) an employee of a
Related Corporation that is not incorporated in the United States, provided that the Board or Committee has designated the employees of such Related Corporation as eligible to participate in the Offering, shall be granted a Purchase Right on the
Offering Date of such Offering. 
 (b) Each person who first becomes an Eligible Employee during an Offering shall not be
granted a Purchase Right under such Offering, but shall be eligible to participate in subsequent Offerings. 
 (c)
Notwithstanding the foregoing, the following Employees shall not be Eligible Employees or be granted Purchase Rights under an Offering: 
 (i) five percent (5%) stockholders (including ownership through unexercised and/or unvested stock options) as described in Section 5(c) of the Plan; or 

(ii) Employees in jurisdictions outside of the United States if, as of the Offering Date of the Offering, the grant of such
Purchase Rights would not be in compliance with the applicable laws of any jurisdiction in which the Employee resides or is employed. 
  

	3.	PURCHASE RIGHTS. 

 (a) Subject to the limitations herein and in the Plan, a Participant’s Purchase Right shall permit the purchase of the number of shares of Common Stock purchasable with up to fifteen percent
(15%) of such Participant’s Earnings paid during the period of such Offering beginning immediately after such Participant first commences participation; provided, however, that no Participant may have more than fifteen percent
(15%) of such Participant’s Earnings applied to purchase shares of Common Stock under all ongoing Offerings under the Plan and all other plans of the Company and Related Corporations that are intended to qualify as Employee Stock Purchase
Plans. 
 (b) For Offerings hereunder, “Earnings” means the base compensation paid to a
Participant, including all salary, wages (including amounts elected to be deferred by such Participant, that would otherwise have been paid, under any cash or deferred arrangement or other deferred compensation program established by the Company or
a Related Corporation), but excluding all of the following: all overtime pay, commissions, bonuses, and other remuneration paid directly to such Participant, profit sharing, the cost of employee benefits paid for by the Company or a Related
Corporation, education or tuition reimbursements, imputed income arising under any Company or Related Corporation group insurance or benefit program, traveling 

  
 2. 

 
expenses, business and moving expense reimbursements, income received in connection with stock options and other equity awards, contributions made by the Company or a Related Corporation under
any employee benefit plan, and other similar items of compensation. 
 (c) Notwithstanding the foregoing, the maximum
number of shares of Common Stock that a Participant may purchase on any Purchase Date in an Offering shall be such number of shares as has a Fair Market Value (determined as of the Offering Date for such Offering) equal to (x) $25,000
multiplied by the number of calendar years in which the Purchase Right under such Offering has been outstanding at any time, minus (y) the Fair Market Value of any other shares of Common Stock (determined as of the relevant Offering Date with
respect to such shares) that, for purposes of the limitation of Section 423(b)(8) of the Code, are attributed to any of such calendar years in which the Purchase Right is outstanding. The amount in clause (y) of the previous sentence shall
be determined in accordance with regulations applicable under Section 423(b)(8) of the Code based on (i) the number of shares previously purchased with respect to such calendar years pursuant to such Offering or any other Offering under
the Plan, or pursuant to any other Company or Related Corporation plans intended to qualify as Employee Stock Purchase Plans, and (ii) the number of shares subject to other Purchase Rights outstanding on the Offering Date for such Offering
pursuant to the Plan or any other such Company or Related Corporation Employee Stock Purchase Plan.  
 (d) The
maximum aggregate number of shares of Common Stock available to be purchased by all Participants under an Offering shall be the number of shares of Common Stock remaining available under the Plan on the Offering Date, rounded down to the nearest
whole share. If the aggregate purchase of shares of Common Stock upon exercise of Purchase Rights granted under all concurrent Offerings would exceed the maximum aggregate number of shares available, the Board shall make a pro rata allocation of the
shares available in a uniform and equitable manner. Any Contributions not applied to the purchase of available shares of Common Stock shall be refunded to the Participants without interest. 

(e) Notwithstanding the foregoing, the maximum number of shares of Common Stock that may be purchased on any single Purchase Date
by any one Eligible Employee during any Offering shall not exceed 35,000 shares. 
 (f) In addition, the maximum number
of shares of Common Stock that may be purchased on any single Purchase Date by all Eligible Employees under all ongoing Offerings shall not exceed 850,000 shares. 
 (g) If the aggregate number of shares of Common Stock to be purchased upon the exercise of all outstanding Purchase Rights on a single Purchase Date would exceed any of the foregoing limits, the
Board shall make a uniform and equitable allocation of the shares available. Any Contributions not applied to the purchase of available shares of Common Stock shall be refunded to the Participants without interest. 

 

	4.	PURCHASE PRICE. 

 The purchase price of shares of Common Stock under an Offering shall be the lesser of: (i) eighty-five percent (85%) of the Fair Market Value of such shares of Common Stock on the

  
 3. 

 
Offering Date, or (ii) eighty-five percent (85%) of the Fair Market Value of such shares of Common Stock on the applicable Purchase Date, in each case rounded up to the nearest whole
cent per share. For the Initial Offering, the Fair Market Value of the shares of Common Stock at the time when the Offering commences shall be the price per share at which shares are first sold to the public in the Company’s initial public
offering as specified in the final prospectus for that initial public offering. 
  

	5.	PARTICIPATION. 

 (a) An Eligible Employee may elect to participate in an Offering to be effective on the Offering Date. An Eligible Employee may enroll in only one Offering at a time. An Eligible Employee shall
elect his or her payroll deduction percentage on such enrollment form as the Company provides. The completed enrollment form must be delivered to the Company at least ten (10) days prior to the date participation is to be effective, unless a
later time for filing the enrollment form is set by the Company for all Eligible Employees with respect to a given Offering. Payroll deduction percentages must be expressed in whole percentages of Earnings, with a minimum percentage of one percent
(1%) and a maximum percentage of fifteen percent (15%). Except as provided in Section 5(e), a Participant may participate only by way of payroll deductions. 
 (b) A Participant may increase or decrease his or her participation level at any time with such change to be effective commencing as of the next Offering. Any such increase or decrease in
participation level shall be made by delivering a notice to the Company or a designated Related Corporation in such form as the Company provides prior to the ten (10) day period (or such shorter period of time as determined by the Company and
communicated to Participants) immediately preceding the next Offering Date for which it is to be effective. A Participant may also increase or decrease his or her participation level to be effective in a subsequent Purchase Period of an ongoing
Offering in accordance with procedures established by the Company. 
 (c) A Participant may increase his or her
participation level once during a Purchase Period. In addition, a Participant may decrease (including a decrease to zero percent (0%)) his or her participation level no more than once during a Purchase Period Any such change in participation level
shall be made by delivering a notice to the Company or a designated Related Corporation in such form as the Company provides prior to the ten (10) day period (or such shorter period of time as determined by the Company and communicated to
Participants) immediately preceding the payroll date for which it is to be effective and such change will become effective as soon as administratively practicable following the Company’s receipt of the notice. 

(d) A Participant may withdraw from an Offering and receive a refund of his or her Contributions (reduced to the extent, if any,
such Contributions have been used to acquire shares of Common Stock for the Participant on any prior Purchase Date) without interest, at any time prior to the end of the Offering, excluding only each ten (10) day period immediately preceding a
Purchase Date (or such shorter period of time determined by the Company and communicated to Participants), by delivering a withdrawal notice to the Company or a designated Related Corporation in such form as the Company provides. A Participant who
has withdrawn from an 

  
 4. 

 
Offering shall not again participate in such Offering, but may participate in subsequent Offerings under the Plan in accordance with the terms of the Plan and the terms of such subsequent
Offerings. 
 (e) Notwithstanding the foregoing or any other provision of this Offering document or of the Plan to the
contrary, neither the enrollment of any Eligible Employee in the Plan nor any forms relating to participation in the Plan shall be given effect until such time as a registration statement covering the shares reserved under the Plan that are subject
to the Offering has been filed by the Company and has become effective. If the provisions of this Section are applicable, the Company shall establish such procedures as will enable the purposes of the Plan to be satisfied while complying with
applicable securities laws. Such procedures may include, for example, allowing Participants to participate other than by means of payroll deduction and/or allowing Participants to increase their level of participation during a Purchase Period.

 (f) Notwithstanding the foregoing or any other provision of this Offering document or of the Plan to the contrary, the
Company may determine in its sole discretion at any time, including at any time following the commencement of an Offering or Purchase Period, that it will no longer accept Participant requests to increase participation levels during such Offering or
Purchase Period, as applicable. 
 (g) Notwithstanding the foregoing or any other provision of this Offering document or
of the Plan to the contrary, with respect to the Initial Offering only, each Eligible Employee who is employed on the Initial Offering date automatically shall be enrolled in the Initial Offering, with a Purchase Right to purchase up to the number
of shares of Common Stock that are purchasable with fifteen percent (15%) of the Eligible Employee’s Earnings, subject to the limitations set forth in Section 3(c) - 3(f) above. Following the filing of an effective registration
statement pursuant to a Form S-8, such Eligible Employee shall be provided a certain period of time, as determined by the Company in its sole discretion, within which to elect to authorize payroll deductions for the purchase of shares during the
Initial Offering (which may be for a percentage that is less than fifteen percent (15%) of the Eligible Employee’s Earnings, and will have a limited opportunity to make all or part of the contributions in a single lump sum cash payment for
the purchase of such shares to the Company or a designated Related Corporation prior to the ten (10) day period (or such shorter period of time as determined by the Company and communicated to Participants) immediately preceding the first
Purchase Date under the Initial Offering. To the extent that the Eligible Employee’s payroll deductions for such initial Purchase Period are less than fifteen percent (15%) of the Eligible Employee’s Earnings paid to the Eligible
Employee during the initial Purchase Period of the Offering, the Eligible Employee may make an additional cash payment at any time or prior to the ten (10) day period (or such shorter period of time as determined by the Company and communicated
to Participants) immediately preceding the Purchase Date under the Initial Offering. Additionally, in accordance with procedures established by the Company for the initial Purchase Period of the Initial Offering, payroll deductions that commence
following the start of the Initial Offering may be made for more than fifteen percent (15%) of Earnings during such payroll periods as necessary to take into account earlier payroll periods in the Initial Offering for which payroll deductions
were not taken, so that the aggregate payroll deductions may equal to up to fifteen percent (15%) of aggregate Earnings for the entire initial Purchase Period of the Initial Offering. If an Eligible Employee neither elects to authorize payroll
deductions nor chooses to make a cash payment in 

  
 5. 

 
accordance with the foregoing sentence, then the Eligible Employee shall not purchase any shares of Common Stock during the Initial Offering. In order to participate in any Offerings that follow
the Initial Offering, an Eligible Employee must affirmatively enroll and authorize payroll deductions prior to the commencement of the Offering, in accordance with paragraph (a) above. 

(h) Once an Eligible Employee affirmatively enrolls in an Offering and authorizes payroll deductions (including in connection with
the Initial Offering), the Eligible Employee automatically shall be enrolled for all subsequent Offerings until he or she elects to withdraw from an Offering pursuant to paragraph (d) above or terminates his or her participation in the Plan.

  

	6.	PURCHASES. 

Subject to the limitations contained herein, on each Purchase Date, each Participant’s Contributions (without any increase for
interest) shall be applied to the purchase of whole shares of Common Stock, up to the maximum number of shares permitted under the Plan and the Offering. 
  

	7.	NOTICES AND AGREEMENTS. 

 Any notices or agreements provided for in an Offering or the Plan shall be given in writing, in a form provided by the Company (including documents delivered in electronic form, if authorized by the
Committee), and unless specifically provided for in the Plan or this Offering, shall be deemed effectively given upon receipt or, in the case of notices and agreements delivered by the Company, five (5) days after deposit in the United States
mail, postage prepaid. 
  

	8.	EXERCISE CONTINGENT ON STOCKHOLDER APPROVAL. 

The Purchase Rights granted under an Offering are subject to the approval of the Plan by the stockholders of the Company as required for
the Plan to obtain treatment as an Employee Stock Purchase Plan. 
  

	9.	CAPITALIZATION ADJUSTMENTS. 

 The limitations set forth in Sections 3(e) and 3(f) shall be adjusted, as appropriate, to reflect Capitalization Adjustments. 

 

	10.	OFFERING SUBJECT TO PLAN. 

Each Offering is subject to all the provisions of the Plan, and the provisions of the Plan are hereby made a part of the Offering. The
Offering is further subject to all interpretations, amendments, rules and regulations which may from time to time be promulgated and adopted pursuant to the Plan. In the event of any conflict between the provisions of an Offering and those of the
Plan (including interpretations, amendments, rules and regulations which may from time to time be promulgated and adopted pursuant to the Plan), the provisions of the Plan shall control. 

  
 6.Loan and Security Agreement

 Exhibit 10.5 
 LOAN AND SECURITY AGREEMENT 
 Dated as of June 2, 2011

 among 
 HORIZON PHARMA USA, INC., 
 HORIZON PHARMA, INC., and 

HORIZON PHARMA (UK) LIMITED, 
 (as Borrowers), 
 OXFORD FINANCE LLC 

(as Administrative Agent) 
 and 
 The Other Lenders Party Hereto 

 TABLE OF CONTENTS 

 

									
	 	 	 	  	 	  	Page	 
			
	1.	 	ACCOUNTING AND OTHER TERMS	  	 	1	  
			
	2.	 	LOANS AND TERMS OF PAYMENT	  	 	1	  
				
		 	    2.1.	  	Promise to Pay	  	 	1	  
		 	    2.2.	  	Term Loans	  	 	1	  
		 	    2.3.	  	Payment of Interest on the Credit Extensions	  	 	2	  
		 	    2.4.	  	Fees. Borrowers shall pay to Administrative Agent:	  	 	2	  
		 	    2.5.	  	Requirements of Law; Increased Costs	  	 	3	  
		 	    2.6.	  	Taxes; Withholding, etc.	  	 	3	  
		 	    2.7.	  	Defaulting Lenders	  	 	5	  
		 	    2.8.	  	Evidence of Debt; Register; Lenders’ Books and Records; Term Loan Notes	  	 	5	  
			
	3.	 	CONDITIONS OF LOANS	  	 	6	  
				
		 	    3.1.	  	Conditions Precedent to Initial Credit Extension	  	 	6	  
		 	    3.2.	  	Conditions Precedent to all Credit Extensions	  	 	8	  
		 	    3.3.	  	Covenant to Deliver	  	 	8	  
		 	    3.4.	  	Procedures for Borrowing	  	 	8	  
			
	4.	 	CREATION OF SECURITY INTEREST	  	 	9	  
				
		 	    4.1.	  	Grant of Security Interest	  	 	9	  
		 	    4.2.	  	Priority of Security Interest	  	 	9	  
		 	    4.3.	  	Authorization to File Financing Statements	  	 	10	  
			
	5.	 	REPRESENTATIONS AND WARRANTIES	  	 	10	  
				
		 	    5.1.	  	Due Organization, Authorization; Power and Authority	  	 	10	  
		 	    5.2.	  	Equity Interests and Ownership	  	 	10	  
		 	    5.3.	  	No Conflict; Government Consents	  	 	10	  
		 	    5.4.	  	Binding Obligation	  	 	10	  
		 	    5.5.	  	Collateral	  	 	11	  
		 	    5.6.	  	Adverse Proceedings, etc.	  	 	11	  
		 	    5.7.	  	Financial Statements; Financial Condition	  	 	12	  
		 	    5.8.	  	Solvency	  	 	12	  
		 	    5.9.	  	Payment of Taxes	  	 	12	  
		 	    5.10.	  	Environmental Matters	  	 	13	  
		 	    5.11.	  	Material Contracts	  	 	13	  
		 	    5.12.	  	Regulatory Compliance	  	 	13	  
		 	    5.13.	  	Margin Stock	  	 	13	  
		 	    5.14.	  	Subsidiaries; Investments	  	 	13	  
		 	    5.15.	  	Employee Matters	  	 	13	  
		 	    5.16.	  	Use of Proceeds	  	 	14	  
		 	    5.17.	  	Full Disclosure	  	 	14	  
		 	    5.18.	  	Patriot Act	  	 	14	  
		 	    5.19.	  	Additional Representations and Warranties	  	 	14	  
			
	6.	 	AFFIRMATIVE COVENANTS	  	 	14	  
				
		 	    6.1.	  	Government Compliance	  	 	14	  
		 	    6.2.	  	Financial Statements, Reports, Certificates	  	 	14	  
		 	    6.3.	  	Inventory; Returns; Maintenance of Properties	  	 	16	  
		 	    6.4.	  	Taxes; Pensions	  	 	16	  
		 	    6.5.	  	Insurance	  	 	17	  
		 	    6.6.	  	Operating Accounts	  	 	17	  
		 	    6.7.	  	Protection of Intellectual Property Rights	  	 	17	  
		 	    6.8.	  	Litigation Cooperation	  	 	18	  

  
 - i -

									
		 	    6.9.	  	Access to Collateral; Books and Records	  	 	18	  
		 	    6.10.	  	Lenders Meetings	  	 	18	  
		 	    6.11.	  	Environmental	  	 	18	  
		 	    6.12.	  	Further Assurances	  	 	19	  
		 	    6.13.	  	Horizon AG Stock Pledge	  	 	19	  
			
	7.	 	NEGATIVE COVENANTS	  	 	19	  
				
		 	    7.1.	  	Dispositions	  	 	19	  
		 	    7.2.	  	Changes in Business, Management, Ownership, or Business Locations	  	 	19	  
		 	    7.3.	  	Mergers or Acquisitions	  	 	20	  
		 	    7.4.	  	Indebtedness	  	 	20	  
		 	    7.5.	  	Encumbrance	  	 	20	  
		 	    7.6.	  	No Further Negative Pledges; Negative Pledge	  	 	20	  
		 	    7.7.	  	Maintenance of Collateral Accounts	  	 	21	  
		 	    7.8.	  	Distributions; Investments	  	 	21	  
		 	    7.9.	  	Restrictions on Subsidiary Distributions	  	 	21	  
		 	    7.10.	  	Disposal of Subsidiary Interests	  	 	21	  
		 	    7.11.	  	Transactions with Affiliates	  	 	21	  
		 	    7.12.	  	Subordinated Debt	  	 	21	  
		 	    7.13.	  	Amendments or Waivers of Organizational Documents	  	 	21	  
		 	    7.14.	  	Fiscal Year	  	 	22	  
		 	    7.15.	  	Compliance	  	 	22	  
		 	    7.16.	  	Non-Guarantor Subsidiaries	  	 	22	  
		 	    7.17.	  	Compliance with Anti-Terrorism Laws	  	 	22	  
		 	    7.18.	  	Existing Kreos Loan Agreement/Horizon AG Indebtedness	  	 	22	  
			
	8.	 	[RESERVED]	  	 	23	  
			
	9.	 	EVENTS OF DEFAULT	  	 	23	  
				
		 	    9.1.	  	Payment Default	  	 	23	  
		 	    9.2.	  	Covenant Default	  	 	23	  
		 	    9.3.	  	Material Adverse Change	  	 	23	  
		 	    9.4.	  	Attachment; Levy; Restraint on Business	  	 	23	  
		 	    9.5.	  	Insolvency	  	 	23	  
		 	    9.6.	  	Other Agreements	  	 	24	  
		 	    9.7.	  	Judgements	  	 	24	  
		 	    9.8.	  	Misrepresentations	  	 	24	  
		 	    9.9.	  	Subordinated Debt	  	 	24	  
		 	    9.10.	  	Existing Kreos Loan Agreement	  	 	24	  
			
	10.	 	RIGHTS AND REMEDIES UPON AN EVENT OF DEFAULT	  	 	24	  
				
		 	    10.1.	  	Rights and Remedies	  	 	24	  
		 	    10.2.	  	Power of Attorney	  	 	25	  
		 	    10.3.	  	Protective Payments	  	 	25	  
		 	    10.4.	  	Application of Payments and Proceeds Upon Default	  	 	25	  
		 	    10.5.	  	Administrative Agent’s Liability for Collateral	  	 	26	  
		 	    10.6.	  	No Waiver; Remedies Cumulative	  	 	26	  
		 	    10.7.	  	Demand Waiver	  	 	26	  
			
	11.	 	ADMINISTRATIVE AGENT	  	 	26	  
				
		 	    11.1.	  	Appointment of Administrative Agent	  	 	26	  
		 	    11.2.	  	Powers and Duties	  	 	26	  
		 	    11.3.	  	General Immunity	  	 	26	  
		 	    11.4.	  	Administrative Agent Entitled to Act as Lender	  	 	27	  
		 	    11.5.	  	Lenders’ Representations, Warranties and Acknowledgment	  	 	28	  
		 	    11.6.	  	Right to Indemnity	  	 	28	  
		 	    11.7.	  	Successor Administrative Agent	  	 	28	  
		 	    11.8.	  	Collateral Documents and Guaranty	  	 	29	  

  
 - ii -

							
		 	    11.9.	  	Withholding Taxes	  	29
			
	12.	 	NOTICES	  	29
			
	13.	 	CHOICE OF LAW, VENUE, AND JURY TRIAL WAIVER	  	31
			
	14.	 	GENERAL PROVISIONS	  	31
				
		 	    14.1.	  	Successors and Assigns	  	31
		 	    14.2.	  	Indemnification	  	32
		 	    14.3.	  	Severability of Provisions	  	32
		 	    14.4.	  	Correction of Loan Documents	  	32
		 	    14.5.	  	Amendments in Writing; Integration	  	32
		 	    14.6.	  	Counterparts	  	33
		 	    14.7.	  	Survival	  	33
		 	    14.8.	  	Confidentiality	  	33
		 	    14.9.	  	Attorneys’ Fees, Costs and Expenses	  	34
		 	    14.10.	  	Right of Set-Off	  	34
		 	    14.11.	  	Marshalling; Payments Set Aside	  	34
		 	    14.12.	  	Obligations Several; Independent Nature of Lenders’ Rights	  	34
		 	    14.13.	  	Electronic Execution of Documents	  	35
		 	    14.14.	  	Captions	  	35
		 	    14.15.	  	Construction of Agreement	  	35
		 	    14.16.	  	Third Parties	  	35
		 	    14.17.	  	No Fiduciary Duty	  	35
		 	    14.18.	  	Borrower Liability	  	35
			
	15.	 	DEFINITIONS	  	36
				
		 	    15.1.	  	Definitions	  	36

  
 - iii -

 LOAN AND SECURITY AGREEMENT 

THIS LOAN AND SECURITY AGREEMENT (this “Agreement”), dated as of June 2, 2011 (the “Effective
Date”) by and among HORIZON PHARMA USA, INC., a Delaware corporation (formerly called HORIZON THERAPEUTICS, INC.) (“Horizon”), HORIZON PHARMA, INC., a Delaware corporation (“Horizon Pharma,”), HORIZON
PHARMA (UK) LIMITED, a company registered under the laws of England and Wales with registration number 5819120, with its registered offices in the United Kingdom at c/o Arnold & Porter (UK) LLP, Tower 42, 24 Old Broad Street, London EC2N
1HQ (“Horizon UK”, and together with Horizon and Horizon Pharma, each a “Borrower” and, collectively, jointly and severally, the “Borrowers”), the Lenders listed on the signature pages hereto or
otherwise party hereto from time to time, and OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria, Virginia 22314 (“Oxford”), as administrative agent for the
Lenders, or any successor administrative agent (in such capacity, the “Administrative Agent”), provides the terms on which the Lenders shall make, and Borrowers shall repay, the Credit Extensions (as hereinafter defined). The
parties agree as follows: 
 1. ACCOUNTING AND OTHER TERMS 

Except as otherwise expressly provided herein, all accounting terms not otherwise defined in this Agreement shall have the meanings assigned to them in
conformity with Applicable Accounting Standards. Calculations and determinations must be made following Applicable Accounting Standards. Capitalized terms not otherwise defined in this Agreement shall have the meanings set forth in
Section 15. All other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the Code to the extent such terms are defined therein. All references to “Dollars” or “$” are
United States Dollars, unless otherwise noted. 
 2. LOANS AND TERMS OF PAYMENT 

2.1. Promise to Pay. 
 Borrowers hereby unconditionally promise to pay each Lender, the outstanding principal amount of all Term Loans advanced to Borrowers by such Lender and accrued and unpaid interest thereon and any other
amounts due hereunder as and when due in accordance with this Agreement. 
 2.2. Term Loans. 

(a) Availability. Subject to the terms and conditions of this Agreement, the Lenders agree, severally and not jointly, to make
term loans to Borrowers during the Draw Period in the aggregate amount of Seventeen Million Dollars ($17,000,000), to be allocated as between the Borrowers as the Borrowers shall determine, according to each Lender’s Term Commitment as set
forth on Schedule 1.1 hereto (such term loans are hereinafter referred to singly as a “Term Loan”, and collectively as the “Term Loans”). All Term Loans shall be made on the same Funding Date. After
repayment, no Term Loan may be re-borrowed. 
 (b) Repayment. Borrowers shall make monthly payments
of interest only commencing on the first
(1st) Payment Date following the Funding Date of the
Term Loans, and continuing on the Payment Date of each successive month thereafter through and including the Payment Date immediately preceding the Amortization Date. Commencing on the Amortization Date, and continuing on the Payment Date of each
month thereafter, Borrowers shall make consecutive equal monthly payments of principal and interest, in arrears, to each Lender, as calculated by Administrative Agent (which calculations shall be deemed correct absent manifest error) based upon:
(1) the amount of such Lender’s Term Loan, (2) the effective rate of interest, as determined in Section 2.3(a), and (3) a repayment schedule equal to thirty-six (36) months. All unpaid principal and accrued and unpaid
interest with respect to the Term Loans is due and payable in full on the Term Loan Maturity Date. The Term Loans may only be prepaid in accordance with Sections 2.2(c) and 2.2(d). 

(c) Mandatory Prepayments. If the Term Loans are accelerated following the occurrence and during the continuance of an Event of
Default, Borrowers shall immediately pay to Lenders, payable to each Lender in accordance with its respective Pro Rata Share, an amount equal to the sum of: (i) all outstanding principal of the Term Loans plus accrued interest thereon through
the prepayment date, (ii) the Final Payment, (iii) the Prepayment Fee, plus (iv) all other sums, that shall have become due and payable, including Lender Expenses and 

 
interest at the Default Rate with respect to any past due amounts. Notwithstanding (but without duplication with) the foregoing, on the Term Loan Maturity Date, if the Final Payment had not
previously been paid in full in connection with the prepayment of the Term Loans in full, Borrowers shall pay to Administrative Agent, for payment to each Lender in accordance with its respective Pro Rata Share, the Final Payment in respect of the
Term Loan(s). 
 (d) Permitted Prepayment of Term Loans. Borrowers shall have the option to prepay all, but not less than
all, of the Term Loans advanced by the Lenders under this Agreement, provided Borrowers (i) provide written notice to Administrative Agent of its election to prepay the Term Loans at least ten (10) days prior to such prepayment, and
(ii) pay to the Lenders on the date of such prepayment, payable to each Lender in accordance with its respective Pro Rata Share, an amount equal to the sum of (A) all outstanding principal of the Term Loans plus accrued interest thereon
through the prepayment date, (B) the Final Payment, (C) the Prepayment Fee, plus (D) all other sums, that shall have become due and payable, including Lender Expenses, if any, and interest at the Default Rate with respect to any past
due amounts. 
 2.3. Payment of Interest on the Credit Extensions. 

(a) Interest Rate. Subject to Section 2.3(b), the principal amount outstanding under the Term Loans shall accrue interest at
a fixed per annum rate (which rate shall be fixed for the duration of the Term Loans) equal to the Basic Rate, determined by Administrative Agent on the Funding Date of the Term Loans, which interest shall be payable monthly in accordance with
Sections 2.2(b) and 2.3(e). Interest shall accrue on each Term Loan commencing on, and including, the day on which the Term Loan is made, and shall accrue on a Term Loan, or any portion thereof, for the day on which the Term Loan or such portion is
paid. 
 (b) Default Rate. Immediately upon the occurrence and during the continuance of an Event of Default, Obligations
shall bear interest at a rate per annum which is five percentage points (5.00%) above the rate that is otherwise applicable thereto (the “Default Rate”). Payment or acceptance of the increased interest rate provided in this
Section 2.3(b) is not a permitted alternative to timely payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or remedies of Administrative Agent. 

(c) 360-Day Year. Interest shall be computed on the basis of a 360-day year consisting of twelve (12) months of thirty
(30) days. 
 (d) Debit of Accounts. Administrative Agent and each Lender may debit any of Borrower’s deposit
accounts, including the Designated Deposit Account, for principal and interest payments or any other amounts Borrowers owe the Lenders under the Loan Documents when due. Each Lender will notify Borrowers promptly after debiting Borrowers’
accounts. These debits shall not constitute a set-off. 
 (e) Payments. Except as otherwise expressly provided herein,
all loan payments by Borrowers hereunder shall be made to the respective Lender to which such payments are owed, at such Lender’s office in immediately available funds on the date specified herein. Unless otherwise provided, interest is payable
monthly on the Payment Date of each month. Payments of principal and/or interest received after 2:00 p.m. Eastern time are considered received at the opening of business on the next Business Day. When a payment is due on a day that is not a Business
Day, the payment is due the next Business Day and additional fees or interest, as applicable, shall continue to accrue until paid. All payments to be made by Borrowers hereunder or under any other Loan Document, including payments of principal and
interest made hereunder and pursuant to any other Loan Document, and all fees, expenses, indemnities and reimbursements, shall be made without set-off, recoupment or counterclaim, in lawful money of the United States and in immediately available
funds. 
 2.4. Fees. Borrowers shall pay to Administrative Agent: 

(a) Facility Fee. A fully earned, non-refundable facility fee of One Hundred Seventy Thousand Dollars ($170,000) to be shared
between the Lenders pursuant to their respective Commitment Percentages as shown on Schedule 1.1, of which One Hundred Thirty Five Thousand Dollars ($135,000) was received by the Lenders prior to the Effective Date. The remaining Thirty Five
Thousand Dollars ($35,000) of the facility fee shall be due and payable on the Effective Date; 

  
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 (b) Final Payment. The Final Payment, when due hereunder, to be shared between the
Lenders in accordance with their respective Pro Rata Shares; 
 (c) Prepayment Fee. The Prepayment Fee, when due
hereunder, to be shared between the Lenders in accordance with their respective Pro Rata Shares; and 
 (d) Lender
Expenses. All Lender Expenses (including reasonable attorneys’ fees and expenses for documentation and negotiation of this Agreement) incurred through and after the Effective Date, when due. 

2.5. Requirements of Law; Increased Costs. In the event that any applicable law, order, regulation, treaty or directive issued or
amended after the Effective Date by any applicable central bank or other Governmental Authority, or any change after the Effective Date in the governmental or judicial interpretation or application thereof, or compliance by any Lender with any
request or directive (whether or not having the force of law) issued subsequent to the date hereof by any central bank or other Governmental Authority: 
 (a) Does or shall subject any Lender to any Tax of any kind whatsoever with respect to this Agreement or any Term Loans made hereunder, or change the basis of taxation of payments to such Lender of
principal, fee, interest or any other amount payable hereunder (except, in each case, for a change in the Tax on the overall net income of, or franchise Taxes payable by, such Lender); 

(b) Does or shall impose, modify or hold applicable any reserve, capital requirement, special deposit, compulsory loan or similar
requirements against assets held by, or deposits or other liabilities in or for the account of, advances or loans by, or other credit extended by, or any other acquisition of funds by, any applicable lending office of any Lender making Term Loans
hereunder; or 
 (c) Does or shall impose on such Lender any other condition; and the result of any of the foregoing is to
increase the cost to such Lender (as determined by such Lender in good faith using calculation methods customary in the industry) of making, renewing or maintaining any Term Loan or to reduce any amount receivable in respect thereof or to reduce the
rate of return on the capital of such Lender or any Person controlling such Lender, then, in any such case, Borrowers shall promptly pay to the Administrative Agent for remittance to such Lender, upon its receipt of the certificate described below,
any additional amounts necessary to compensate such Lender for such additional cost or reduced amounts receivable or rate of return as reasonably determined by such Lender with respect to this Agreement or the Term Loans made hereunder. If a Lender
becomes entitled to claim any additional amounts pursuant to this Section 2.5, it shall promptly notify Borrowers through the Administrative Agent of the event by reason of which it has become so entitled, and a certificate as to any
additional amounts payable pursuant to the foregoing sentence containing the calculation thereof in reasonable detail submitted by a Lender, through the Administrative Agent, to Borrowers shall be conclusive in the absence of manifest error. The
provisions hereof shall survive the termination of this Agreement and payment of the outstanding Term Loans and all other Obligations. 
 (d) Failure or delay on the part of any Lender to demand compensation for any increased costs or reduction in amounts received or receivable or reduction in return on capital shall not constitute a waiver
of such Lender’s right to demand such compensation; provided that Borrowers shall not be under any obligation to compensate any Lender under this Section 2.5 with respect to increased costs or reductions with respect to any period
prior to the date that is 180 days prior to the date of the delivery of the statement required pursuant to the foregoing paragraph; provided further that the foregoing limitation shall not apply to any increased costs or reductions arising out of
the retroactive application of any change in any law, treaty, governmental rule, regulation or order within such 180-day period. 
 2.6. Taxes; Withholding, etc. 
 (a) All sums payable by any Credit Party
hereunder and under the other Loan Documents shall (except to the extent required by law) be paid free and clear of, and without any deduction or withholding on account of, any Tax (other than a Tax on the overall net income of any Lender) imposed,
levied, collected, withheld or assessed by or within the United States of America or any political subdivision in or of the United States of America, the United Kingdom, or any other jurisdiction from or to which a payment is made by or on behalf of
any 

  
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Credit Party or by any federation or organization of which the United States of America, the United Kingdom, or any such jurisdiction is a member at the time of payment. In addition, Borrowers
agree to pay, and shall indemnify and hold each Lender harmless from, any present or future stamp or documentary Taxes or any other sales, transfer, excise, mortgage recording or property Taxes, charges or similar levies that arise from any payment
made hereunder or under the Term Loans or from the execution, issuance, delivery or registration of, any of the Loan Documents, and within thirty days after the date of paying such sum, the Borrowers shall furnish to the Lender the original or a
certified copy of a receipt evidencing payment thereof. If a Lender or the Administrative Agent shall become aware that it is entitled to receive a refund in respect of amounts paid by any Credit Party pursuant to this Section 2.6, which
refund in the good faith judgment of such Lender or the Administrative Agent is allocable to such payment, it shall promptly notify such Credit Party of the availability of such refund and shall, within 30 days after the receipt of a request by such
Credit Party, apply for such refund. If any Lender or the Administrative Agent receives a refund in respect of any amounts paid by any Credit Party pursuant to this Section 2.6 or any Lender receives a credit against the Tax on the
overall net income of the Lender, which refund or credit in the good faith judgment of such Lender or the Administrative Agent is allocable to such payment, it shall promptly notify such Credit Party of such refund or credit and shall, within 30
days after receipt, repay such refund or credit to such Credit Party net of all out-of-pocket expenses of such Lender or the Administrative Agent; provided, however, that such Credit Party, upon the request of such Lender or the Administrative
Agent, agrees to repay the amount paid over to such Credit Party to such Lender or the Administrative Agent in the event such Lender or the Administrative Agent is required to repay such refund or credit. 

(b) If any Credit Party or any other Person is required by law to make any deduction or withholding on account of any such Tax from any
sum paid or payable by any Credit Party to the Administrative Agent or any Lender under any of the Loan Documents: (i) Borrowers shall notify the Administrative Agent of any such requirement or any change in any such requirement as soon as any
Borrower becomes aware of it; (ii) Borrowers shall pay any such Tax before the date on which penalties attach thereto, such payment to be made (if the liability to pay is imposed on any Credit Party) for its own account or (if that liability is
imposed on the Administrative Agent or such Lender, as the case may be) on behalf of and in the name of the Administrative Agent or such Lender; (iii) the sum payable by such Credit Party in respect of which the relevant deduction, withholding
or payment is required shall be increased to the extent necessary to ensure that, after the making of that deduction, withholding or payment (including any deductions applicable to additional sums payable under this Section 2.6(b), the
Administrative Agent or such Lender, as the case may be, receives on the due date a net sum equal to what it would have received had no such deduction, withholding or payment been required or made; and (iv) within thirty days after paying any
sum from which it is required by law to make any deduction or withholding, and within thirty days after the due date of payment of any Tax which it is required by clause (ii) above to pay, Borrowers shall deliver to the Administrative Agent
evidence satisfactory to the other affected parties of such deduction, withholding or payment and of the remittance thereof to the relevant taxing or other Governmental Authority; provided, no such additional amount shall be required to be paid to
any Lender under clause (iii) above except to the extent that any change after the date hereof in any such requirement for a deduction, withholding or payment as is mentioned therein shall result in an increase in the rate of such deduction,
withholding or payment from that in effect at the date hereof, in respect of payments to such Lender. In the event that all or any portion of this Agreement is assigned by a Lender, no such additional amount shall be required to be paid to any
assignee under clause (iii) above except to the extent that, after the date of the Assignment Agreement, any change in any such requirement for a deduction, withholding or payment shall result in an increase in the rate of such deduction,
withholding or payment from that in effect on the date of the Assignment Agreement. The Borrowers shall indemnify for the full amount of any deduction, withholding, or payment made pursuant to this Section 2.6(b) (including without
limitation any Taxes imposed by any jurisdiction on amounts payable under this Section 2.6(b) paid by each Lender and any liability (including penalties, interest and expense) arising therefrom or with respect thereto. Any
indemnification payment pursuant to this Section 2.6 shall be made within thirty days from written demand therefor. 
 (c)
Each Lender that is not a United States Person (as such term is defined in Section 7701(a)(30) of the Internal Revenue Code) for U.S. federal income Tax purposes (a “Non U.S. Lender”) shall deliver to the Administrative Agent
for transmission to Borrowers, on or prior to the Effective Date, and at such other times as may be necessary in the determination of Borrowers or the Administrative Agent (each in the reasonable exercise of its discretion), two original copies of
Internal Revenue Service Form W 8BEN or W 8ECI (or any successor forms), properly completed and duly executed by such Lender, and such other documentation required under the Internal Revenue Code and reasonably requested by Borrowers to establish
that such Lender is not subject to deduction or withholding of United States federal income Tax with respect to any payments to such Lender of 

  
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principal, interest, fees or other amounts payable under any of the Loan Documents. Each Lender that is a United States person (as such term is defined in Section 7701(a)(30) of the Internal
Revenue Code) for United States federal income Tax purposes (a “U.S. Lender”) shall deliver to the Administrative Agent and Borrowers on or prior to the Effective Date two original copies of Internal Revenue Service Form W-9 (or any
successor form), properly completed and duly executed by such Lender, certifying that such U.S. Lender is entitled to an exemption from United States backup withholding, or otherwise prove that it is entitled to such an exemption. Each Lender
required to deliver any forms, certificates or other evidence with respect to United States federal income Tax or backup withholding matters pursuant to this Section 2.6(c) hereby agrees, from time to time after the initial delivery by
such Lender of such forms, certificates or other evidence, whenever a lapse in time or change in circumstances renders such forms, certificates or other evidence obsolete or inaccurate in any material respect, that such Lender shall promptly deliver
to the Administrative Agent for transmission to Borrowers two new original copies of Internal Revenue Service Form W-8BEN or W-8ECI or W-9 (or any successor form), as the case may be, properly completed and duly executed by such Lender, and such
other documentation required under the Internal Revenue Code and reasonably requested by Borrowers to confirm or establish that such Lender is not subject to deduction, backup withholding or withholding of United States federal income Tax with
respect to payments to such Lender under the Loan Documents, or notify the Administrative Agent and Borrowers of its inability to deliver any such forms, certificates or other evidence. Borrowers shall not be required to pay any additional amount to
any Non U.S. Lender under Section 2.6(b)(iii) if such Lender shall have failed (1) to deliver the forms, certificates or other evidence referred to in this Section 2.6(c), or (2) to notify the Administrative Agent
and Borrowers of its inability to deliver any such forms, certificates or other evidence, as the case may be; provided, if such Lender shall have satisfied the requirements of the first sentence of this Section 2.6(c) on the Effective
Date, nothing in this last sentence of this Section 2.6(c) shall relieve Borrowers of their obligations to pay any additional amounts pursuant to this Section 2.6 in the event that, as a result of any change in any applicable
law, treaty or governmental rule, regulation or order, or any change in the interpretation, administration or application thereof, such Lender is no longer properly entitled to deliver forms, certificates or other evidence at a subsequent date
establishing the fact that such Lender is not subject to withholding as described herein. 
 2.7. Defaulting Lenders.
Anything contained herein to the contrary notwithstanding, in the event that any Lender, other than at the direction or request of any regulatory agency or authority, defaults (a “Defaulting Lender”) in its obligation to fund (a
“Funding Default”) any Term Loan (in each case, a “Defaulted Loan”), then (a) during any Default Period with respect to such Defaulting Lender, such Defaulting Lender shall be deemed not to be a
“Lender” for purposes of voting on any matters (including the granting of any consents or waivers) with respect to any of the Loan Documents; and (b) to the extent permitted by applicable law, until such time as the Defaulting Lender
shall have cured such Funding Default, (i) any voluntary prepayment of the Term Loans shall, if such paying Borrower so directs at the time of making such voluntary prepayment, be applied to the Term Loans of other Lenders as if such Defaulting
Lender had no Term Loans outstanding, and (ii) any mandatory prepayment of the Term Loans shall, if such paying Borrower so directs at the time of making such mandatory prepayment, be applied to the Term Loans of other Lenders (but not to the
Term Loans of such Defaulting Lender) as if such Defaulting Lender had funded all Defaulted Loans of such Defaulting Lender, it being understood and agreed that such paying Borrower shall be entitled to retain any portion of any mandatory prepayment
of the Term Loans that is not paid to such Defaulting Lender solely as a result of the operation of the provisions of this clause (b). No Term Commitment of any Lender shall be increased or otherwise affected, and, except as otherwise expressly
provided in this Section 2.7, performance by Borrowers of their obligations hereunder and the other Loan Documents shall not be excused or otherwise modified as a result of any Funding Default or the operation of this
Section 2.7. The rights and remedies against a Defaulting Lender under this Section 2.7 are in addition to other rights and remedies which Borrowers may have against such Defaulting Lender with respect to any Funding Default
and which the Administrative Agent or any Lender may have against such Defaulting Lender with respect to any Funding Default. 

2.8. Evidence of Debt; Register; Lenders’ Books and Records; Term Loan Notes. 

(a) Lenders’ Evidence of Debt. Each Lender shall maintain on its internal records an account or accounts evidencing the
Obligations of each Borrower to such Lender, including the amounts of the Term Loans made by it and each repayment and prepayment in respect thereof. Any such recordation shall be conclusive and binding on Borrowers, absent manifest error; provided,
that the failure to make any such recordation, or any error in such recordation, shall not affect any Lender’s Term Commitments or Borrowers’ Obligations in respect of any applicable Term Loans; and provided further, in the event of any
inconsistency between the Register and any Lender’s records, the recordations in the Register shall govern, absent manifest error. 

  
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 (b) Register. Administrative Agent (or its agent or sub-agent appointed by it) shall
maintain at its principal office (as specified in, or as otherwise identified upon notice to the other parties hereto in accordance with, Section 12), a register for the recordation of the names and addresses of Lenders, the Term
Commitments, and related principal of, and interest on, the Term Loans of each from time to time (the “Register”). The Register shall be available for inspection by Borrowers, any Lender (with respect to any entry relating to such
Lender’s Term Loans) at any reasonable time and from time to time upon reasonable prior notice. Administrative Agent shall record, or shall cause to be recorded, in the Register the Term Commitments and the related principal of, and interest
on, the Term Loans of each Lender in accordance with the provisions of Section 14.1, and each repayment or prepayment in respect of the principal amount of the Term Loans and any such recordation shall be conclusive and binding on
Borrowers and each Lender, absent manifest error; provided, failure to make any such recordation, or any error in such recordation, shall not affect any Lender’s Term Commitments or Borrowers’ Obligations in respect of any Term Loan.
Borrowers hereby designate Administrative Agent to serve as Borrowers’ agent solely for purposes of maintaining the Register as provided in this Section 2.8, and Borrowers hereby agree that, to the extent Administrative Agent serves
in such capacity, Administrative Agent and its officers, directors, employees, agents, sub-agents and affiliates shall constitute “Indemnified Persons.” 
 (c) Term Loan Notes. If so requested by any Lender by written notice to Borrowers (with a copy to Administrative Agent) at least two Business Days prior to the Funding Date of any Term Loan, or at
any time thereafter, Borrower with respect to such Term Loan shall execute and deliver to such Lender (and/or, if applicable and if so specified in such notice, to any Person who is an assignee of such Lender pursuant to Section 14.1 on
such Funding Date (or, if such notice is delivered after such Funding Date, promptly after Borrowers’ receipt of such notice) a Term Loan Note to evidence such Lender’s Term Loan. 

3. CONDITIONS OF LOANS 
 3.1. Conditions Precedent to Initial Credit Extension. Each Lender’s obligation to advance the Term Loans is subject to the condition precedent that the Administrative Agent shall have
received, in form and substance satisfactory to the Administrative Agent, such documents, and completion of such other matters, as the Administrative Agent may reasonably deem necessary or appropriate, including, without limitation: 

(a) copies of the Loan Documents originally executed and delivered by each applicable Credit Party, and each schedule to such Loan
Documents (such schedules to be in form and substance reasonably satisfactory to the Administrative Agent); 
 (b) Operating
Documents of each of the Credit Parties; 
 (c) the Perfection Certificates for Borrowers; 

(d) the organizational structure and capital structure of each of the Credit Parties shall be as set forth on Schedule 3.1(d);

 (e) (i) a good standing certificate of Horizon, certified by the Secretary of State of the State of Delaware as of a date no
earlier than thirty (30) days prior to the Effective Date; (ii) a good standing certificate of Horizon Pharma, certified by the Secretary of State of the State of Delaware as of a date no earlier than thirty (30) days prior to the
Effective Date; and (iii) a certificate of the secretary of Horizon UK with respect to its certificate of incorporation, memorandum and articles of association, register of charges, specimen signatures and board minutes authorizing the
execution and delivery of this Agreement, the Debenture and the other documents required by the Administrative Agent in connection therewith; 
 (f) Secretary’s Certificate with completed Borrowing Resolutions for each Credit Party; 
 (g) (i) certified copies, dated as of a recent date, of financing statement searches, as the Administrative Agent shall request, accompanied by written evidence (including any UCC termination statements)
that the Liens indicated in any such financing statements either constitute Permitted Liens or have been or, in connection with the initial Credit Extension, will be terminated or released and (ii) the results of a search at Companies House
with respect to Horizon UK indicating there are no Liens other than Permitted Liens and otherwise in form and substance satisfactory to the Administrative Agent; 

  
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 (h) each Credit Party shall have obtained all Governmental Approvals and all consents of
other Persons, in each case that are necessary or advisable in connection with the transactions contemplated by the Loan Documents and each of the foregoing shall be in full force and effect and in form and substance reasonably satisfactory to the
Administrative Agent. All applicable waiting periods shall have expired without any action being taken or threatened by any competent authority which would restrain, prevent or otherwise impose adverse conditions on the transactions contemplated by
the Loan Documents or the financing thereof and no action, request for stay, petition for review or rehearing, reconsideration, or appeal with respect to any of the foregoing shall be pending, and the time for any applicable agency to take action to
set aside its consent on its own motion shall have expired; 
 (i) if requested by the Administrative Agent, a landlord’s
consent in favor of the Administrative Agent for each Credit Party’s leased locations by the respective landlord thereof (which consent shall include an agreement by such landlord to permit reasonable access to such leased premises by the
Administrative Agent or its agents upon an Event of Default for purposes of removal of any and all Collateral, if such leased premises is a warehouse, distribution center or other location at which a material amount of Collateral is located),
together with the duly executed original signatures thereto; 
 (j) opinions of counsel (which counsel shall be reasonably
satisfactory to the Administrative Agent) with respect to the creation and perfection of the security interests in favor of the Administrative Agent in such Collateral and such other matters governed by the laws of each jurisdiction in which any
Credit Party or any personal property Collateral is located as the Administrative Agent may reasonably request, in each case in form and substance reasonably satisfactory to Administrative Agent; 

(k) a copy of any registration rights agreement, investors’ rights agreement or other similar agreement relating to, governing or
otherwise affecting the ownership of the capital stock or other equity ownership interests of any Credit Party, and any amendments thereto; 
 (l) evidence that the insurance policies required by Section 6.5 hereof are in full force and effect, together with appropriate evidence showing loss payable and/or additional insured clauses
or endorsements in favor of the Administrative Agent, for the ratable benefit of the Lenders; 
 (m) payoff letters from Kreos
and Silicon Valley Bank in respect of the Indebtedness outstanding under the Existing Kreos/SVB Loan Agreement; 
 (n) evidence
that Kreos has released Horizon and Horizon Pharma from any Indebtedness, guaranty or other obligations in respect of the Existing Kreos Loan Agreement except for the pledge by Horizon Pharma of the Horizon AG Capital Stock (as defined in Exhibit A)
on terms and conditions satisfactory to the Lenders in their sole discretion (the “Horizon AG Stock Pledge”); 

(o) evidence that (i) the Liens securing any Indebtedness, guaranty or other obligations of the Borrowers to Kreos under the
Existing Kreos Loan Agreement have been terminated, (ii) the Liens securing any Indebtedness, guaranty or other obligations of the Borrowers to Kreos or SVB under the the Existing Kreos/SVB Loan Agreement have been terminated and (iii) the
documents and/or filings evidencing the perfection of the foregoing Liens, including without limitation any financing statements and/or control agreements, have or will, concurrently with the initial Credit Extension, be terminated; 

(p) evidence that each Credit Party shall have taken or caused to be taken any other action, executed and delivered or caused to be
executed and delivered any other agreement, document and instrument and made or caused to be made any other filing and recording (other than as set forth herein) reasonably required by the Administrative Agent; 

(q) all documentation and other information required by bank regulatory authorities under applicable “know-your-customer” and
anti-money laundering rules and regulations, including the U.S.A. Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (the “Patriot Act”); 

(r) copies of the Warrants originally executed and delivered by Horizon Pharma to Oxford and SVB; 

  
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 (s) the original intercompany note dated June 28, 2010 issued by Horizon AG to Horizon
Pharma in the original principal amount of $5,500,000, duly endorsed to the Administrative Agent (as the same may be amended from time to time to evidence advances from the Borrowers to Horizon AG permitted hereunder, the “Horizon AG
Intercompany Note”) ; 
 (t) evidence that Horizon Pharma has purchased from Kreos, and that Kreos has assigned to
Horizon Pharma, all of Kreos’ rights, title and interest in and to €1,000,000 principal amount of the loans under the Existing Kreos Loan Agreement and all related rights thereto under the Existing Kreos Loan Agreement and related loan
documents, which interest, upon such purchase and sale and assignment, shall be evidenced by an original intercompany note dated June 2, 2011 issued by Horizon AG to Horizon Pharma in the principal amount of €1,000,000, and delivered to
the Administrative Agent duly endorsed to the Administrative Agent (“Additional Horizon AG Intercompany Note”); 
 (u) evidence that DUEXIS has been approved for sale to the public by the FDA; and 

(v) payment of the fees and Lender Expenses then due as specified in Section 2.4 hereof. 

3.2. Conditions Precedent to all Credit Extensions. The obligation of each Lender to make each Credit Extension, including the
Term Loans, is subject to the following conditions precedent: 
 (a) except as otherwise provided in Section 3.4,
timely receipt of one or more executed Payment/Advance Form in the form of Exhibit B hereto; 
 (b) the
representations and warranties of the Credit Parties in this Agreement shall be true, accurate, and complete in all material respects on the date of the Payment/Advance Form and on the Funding Date of each Credit Extension; provided, however, that
such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring
to a specific date shall be true, accurate and complete in all material respects as of such date, and no Event of Default shall have occurred and be continuing or result from the Credit Extension. Each Credit Extension is the Credit Parties’
representation and warranty on that date that the representations and warranties of the Credit Parties in this Agreement remain true, accurate, and complete in all material respects; provided, however, that such materiality qualifier shall not be
applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true,
accurate and complete in all material respects as of such date; 
 (c) in the Administrative Agent’s sole discretion, there
has not been any material impairment in the general affairs, management, results of operation, financial condition or the prospect of repayment of the Obligations, or any material adverse deviation by the Credit Parties from the most recent business
plan of the Credit Parties presented to and accepted by the Administrative Agent; 
 (d) as of the date of such Credit
Extension, no event shall have occurred and be continuing or would result from the consummation of the applicable Credit Extension that would constitute an Event of Default hereunder; and 

(e) payment of the fees and Lender Expenses then due as specified in Section 2.4 hereof. 

3.3. Covenant to Deliver. The Credit Parties agree to deliver to the Administrative Agent each item required to be delivered to
the Administrative Agent under this Agreement as a condition precedent to any Credit Extension. The Credit Parties expressly agree that a Credit Extension made prior to the receipt by the Administrative Agent of any such item shall not constitute a
waiver by the Administrative Agent of the Credit Parties’ obligation to deliver such item, and the making of any Credit Extension in the absence of a required item shall be in the Administrative Agent’s sole discretion. 

3.4. Procedures for Borrowing. Subject to the prior satisfaction of all other applicable conditions to the making of a Term Loan
set forth in this Agreement, to obtain a Term Loan, Borrowers shall notify the Administrative Agent (which notice shall be irrevocable on and after the date on which such notice is given and 

  
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Borrowers shall be bound to make a borrowing in accordance therewith) by electronic mail, facsimile, or telephone by 12:00 noon Eastern time no less than one (1) Business Day prior to the
date the Term Loan is to be made. Together with any such electronic or facsimile notification, Borrowers shall deliver to the Administrative Agent by electronic mail or facsimile a completed Payment/Advance Form for each requested Term Loan executed
by a Responsible Officer of each applicable Borrower, or his or her designee. The Administrative Agent may rely on any telephone notice given by a person who the Administrative Agent believes is a Responsible Officer or designee. Each Lender shall
make the amount of its Pro Rata Share of each Term Loan available to Administrative Agent not later than 12:00 p.m. (Eastern time) on the applicable Funding Date by wire transfer of same day funds in Dollars, at the Principal Office designated by
the Administrative Agent. Except as provided herein, upon satisfaction or waiver of the conditions precedent to the making of Term Loans specified herein, the Administrative Agent shall make the proceeds of such Term Loans available to the
requesting Borrower(s) on the applicable Funding Date by causing an amount of same day funds in Dollars equal to the proceeds of all such Term Loans received by Administrative Agent from Lenders to be made available to the requesting Borrower(s) by
wire transfer of immediately available funds in Dollars to such account as may be designated in writing to the Administrative Agent by the requesting Borrower(s). 
 4. CREATION OF SECURITY INTEREST 
 4.1. Grant of Security
Interest. Each of the Credit Parties hereby grants the Administrative Agent, for the ratable benefit of the Lenders, to secure the payment and performance in full of all of the Obligations, a continuing security interest in, and pledges to the
Administrative Agent, for the ratable benefit of the Lenders, the Collateral, wherever located, whether now owned or hereafter acquired or arising, and all proceeds and products thereof. Without limiting the foregoing, the Obligations shall also be
secured by the Debenture creating a first-ranking continuing Lien and security interest in the Collateral and any and all other security agreements, mortgages, charges (including, without limitation, the Supplemental Debenture) granted now or in
future by Horizon UK in favor of the Administrative Agent as security trustee for the Lenders. 
 4.2. Priority of Security
Interest. 
 (a) Each Credit Party represents, warrants, and covenants that the security interest granted herein is
and shall at all times continue to be a first priority perfected security interest in the Collateral (subject only to Permitted Liens that are permitted by the terms of this Agreement to have superior priority to the Lien in favor of the
Administrative Agent and the Lenders). If a Credit Party shall acquire a commercial tort claim, such Credit Party shall promptly notify the Administrative Agent in a writing signed by such Credit Party of the general details thereof and grant to the
Administrative Agent, for the ratable benefit of the Lenders, in such writing a security interest therein and in the proceeds thereof, all upon the terms of this Agreement, with such writing to be in form and substance reasonably satisfactory to the
Administrative Agent. 
 (b) Notwithstanding anything herein to the contrary, upon the receipt by the Administrative Agent of a
certificate of a Responsible Officer certifying that Horizon Pharma has generated monthly sales of DUEXIS products of not less than $3,750,000 for three (3) consecutive months (the “DUEXIS Sales Target”), the security
interest granted hereby by the Credit Parties with respect to the Intellectual Property Collateral shall automatically terminate, and the Administrative Agent shall promptly thereafter, at the sole cost and expense of the Credit Parties, execute and
deliver to the Credit Parties all such documents and instruments as shall be necessary to evidence termination of such security interest; provided that, if a judicial authority (including a U.S. Bankruptcy Court) would hold that a security interest
in the underlying Intellectual Property Collateral is necessary to have a security interest in the IP Collateral Proceeds, then the Collateral shall automatically, and effective as of the Effective Date, include the Intellectual Property Collateral
to the extent necessary to permit perfection of the Administrative Agent’s security interest in such IP Collateral Proceeds. 
 (c) If this Agreement is terminated, the Administrative Agent’s Lien in the Collateral shall continue until the Obligations (other than inchoate indemnity obligations) are repaid in full in cash.
Upon payment in full in cash of the Obligations (other than inchoate indemnity obligations) and at such time as the Lenders’ obligations to make Credit Extensions has terminated, the Administrative Agent shall, at the Credit Parties’ sole
cost and expense, release its Liens in the Collateral and all rights therein shall revert to the appropriate Credit Parties. 

  
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 4.3. Authorization to File Financing Statements. The Credit Parties hereby authorize
the Administrative Agent to file financing statements, without notice to the Credit Parties, with all appropriate jurisdictions to perfect or protect the Administrative Agent’s interest or rights hereunder, including a notice that any
disposition of the Collateral, by either the Credit Parties or any other Person, shall be deemed to violate the rights of the Administrative Agent under the Code, except dispositions permitted hereunder. Such financing statements may indicate the
Collateral as “all assets of the Debtor” or words of similar effect, or as being of an equal or lesser scope, or with greater detail, all in the Administrative Agent’s discretion. 

5. REPRESENTATIONS AND WARRANTIES 
 In order to induce Lenders and the Administrative Agent to enter into this Agreement and to make each Credit Extension to be made thereby, each Credit Party, jointly and severally, represents and warrants
to each Lender and the Administrative Agent that the following statements are true and correct: 
 5.1. Due Organization,
Authorization; Power and Authority. Each Credit Party (a) is duly organized, validly existing and in good standing under the laws of its jurisdiction of organization as identified in Schedule 5.1, (b) has all requisite power and
authority to own and operate its properties, to carry on its business as now conducted and as proposed to be conducted, to enter into the Loan Documents to which it is a party and to carry out the transactions contemplated thereby, and (c) is
qualified to do business and in good standing in every jurisdiction where its assets are located and wherever necessary to carry out its business and operations except where the failure to do so could not reasonably be expected to have a material
adverse effect on its business. 
 5.2. Equity Interests and Ownership. The Equity Interests of each Credit Party
have been duly authorized and validly issued and are fully paid and non assessable. Except as set forth on Schedule 5.2, as of the date hereof, there is no existing option, warrant, call, right, commitment or other agreement to which any
Credit Party is a party requiring, and there is no membership interest or other Equity Interests of any Credit Party outstanding which upon conversion or exchange would require, the issuance by any Credit Party of any additional membership interests
or other Equity Interests of any Credit Party or other Equity Interests convertible into, exchangeable for or evidencing the right to subscribe for or purchase, a membership interest or other Equity Interests of any Credit Party. Schedule 5.2
correctly sets forth the ownership interest of each Credit Party in its respective Subsidiaries as of the Effective Date. The organizational structure and capital structure of each of the Credit Parties is as set forth on Schedule 3.1(d).

 5.3. No Conflict; Government Consents. The execution, delivery and performance by each Credit Party of the Loan
Documents to which it is a party have been duly authorized and do not (i) conflict with any of such Credit Party’s Operating Documents, (ii) contravene, conflict with, constitute a default under or violate any material Requirement of
Law, (iii) contravene, conflict or violate any applicable order, writ, judgment, injunction, decree, determination or award of any Governmental Authority by which such Credit Party or any of its Subsidiaries or any of their property or assets
may be bound or affected, (iv) require any action by, filing, registration, or qualification with, or Governmental Approval from, any Governmental Authority (except (x) such Governmental Approvals which have already been obtained and are
in full force and effect, (y) for filings and recordings with respect to the Collateral to be made, or otherwise delivered to the Administrative Agent for filing and/or recordation on or after the Effective Date and (z) any registration,
consent, approval, notice or action to the extent that the failure to undertake or obtain such registration, consent, approval, notice or action could not reasonably be expected to result in a Material Adverse Change), (v) constitute an event
of default under any material agreement by which such Credit Party is bound or (vi) require any approval of stockholders, members or partners or any approval or consent of any Person except for such approvals or consents which will be obtained
on of before the Effective Date and disclosed in writing to the Administrative Agent and except for any such approvals or consents the failure of which to obtain will not result in a Material Adverse Change. No Credit Party is in default under any
agreement to which it is a party or by which it is bound in which the default could reasonably be expected to have a material adverse effect on such Credit Party’s business. 

5.4. Binding Obligation. Each Loan Document has been duly executed and delivered by each Credit Party that is a party thereto and
is the legally valid and binding obligation of such Credit Party, enforceable against such Credit Party in accordance with its respective terms, except as may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws relating
to or limiting creditors’ rights generally or by equitable principles relating to enforceability. 

  
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 5.5. Collateral. In connection with this Agreement, each Credit Party has
delivered to the Administrative Agent a completed certificate signed by such Credit Party, (each, a “Perfection Certificate, and collectively, the “Perfection Certificates”). Each Credit Party represents and warrants to
the Administrative Agent that: 
 (a) (i) its exact legal name is that indicated on its Perfection Certificate and on the
signature page hereof; (ii) it is an organization of the type and is organized in the jurisdiction set forth in its Perfection Certificate; (iii) its Perfection Certificate accurately sets forth its organizational identification number or
accurately states that it has none; (iv) its Perfection Certificate accurately sets forth its place of business, or, if more than one, its chief executive office as well as its mailing address (if different than its chief executive office);
(v) it (and each of its predecessors) has not, in the past five (5) years, changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its jurisdiction; and (vi) all other
information set forth on its Perfection Certificate pertaining to it and each of its Subsidiaries is accurate and complete (it being understood and agreed that each Credit Party may from time to time update certain information in its Perfection
Certificate after the Effective Date to the extent permitted by one or more specific provisions in this Agreement). If any Credit Party is not now a Registered Organization but later becomes one, it shall promptly notify the Administrative Agent of
such occurrence and provide the Administrative Agent with such Credit Party’s organizational identification number. The Administrative Agent and the Lenders hereby agree that the Perfection Certificates shall be deemed to be updated to reflect
information provided in any notice delivered by any Credit Party to the Administrative Agent pursuant to the last full paragraph of Section 7.2 below; provided that any update to the Perfection Certificates by any Credit Party pursuant
to the last full paragraph of Section 7.2 below shall not relieve any Credit Party of any other Obligation under this Agreement, including (without limitation) its Obligations pursuant to Section 6.7(b). 

(b) (i) it has good title to, has rights in, and the power to transfer each item of the Collateral upon which it purports to grant a Lien
hereunder, free and clear of any and all Liens except Permitted Liens, (ii) it has no deposit accounts, securities accounts, commodity accounts or other investment accounts other than the deposit accounts, securities accounts, commodity
accounts or other investment accounts with Silicon Valley Bank, the deposit accounts, securities accounts, commodity accounts or other investment accounts, if any, described in the Perfection Certificates delivered to the Administrative Agent in
connection herewith, or of which such Credit Party has given the Administrative Agent notice and taken such actions as are necessary to give Administrative Agent a perfected security interest therein (and upon delivery of such notice and taking such
action, the Perfection Certificates will be deemed to be updated with the information contained in such notice), (iii) Collateral is not in the possession of any third party bailee (such as a warehouse) except as otherwise provided in the
Perfection Certificates or as permitted pursuant to Section 7.2. None of the components of the Collateral shall be maintained at locations other than as provided in the Perfection Certificate or as permitted pursuant to
Section 7.2. 
 (c) All Inventory is in all material respects of good and marketable quality, free from material
defects. 
 (d) It is the sole owner of the Intellectual Property which it owns or purports to own except for (a) Permitted
Licenses, (b) over-the-counter software that is commercially available to the public, and (c) material Intellectual Property licensed to it and noted on the Perfection Certificates (as the same may be updated from time to time). Each
Patent which it owns or purports to own and which is material to its business is valid and enforceable, and no part of the Intellectual Property which it owns or purports to own and which is material to it business has been judged invalid or
unenforceable, in whole or in part. To the best of its knowledge, no claim has been made that any part of its Intellectual Property violates the rights of any third party except to the extent such claim would not reasonably be expected to have a
material adverse effect on its business. 
 (e) Except as noted on its Perfection Certificate (as the same may be updated from
time to time), it is not a party to, nor is it bound by, any Restricted License. 
 (f) The assets of Horizon GmbH (excluding
intercompany receivables and $100,000 in cash in the aggregate) do not exceed One Million Dollars ($1,000,000) in the aggregate. 
 5.6. Adverse Proceedings, etc. There are no Adverse Proceedings, individually or in the aggregate, that could reasonably be expected to result in a Material Adverse Change. No Credit Party
(a) is in violation of any applicable laws (including Environmental Laws) that, individually or in the aggregate, could reasonably be expected 

  
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to result in a Material Adverse Change, or (b) is subject to or in default with respect to any final judgments, orders, writs, injunctions, decrees, rules or regulations of any court or any
federal, state, municipal or other governmental department, commission, board, bureau, agency or instrumentality, domestic or foreign, that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change.

 5.7. Financial Statements; Financial Condition. All consolidated financial statements for any Credit Party
delivered to the Administrative Agent were prepared in conformity with Applicable Accounting Standards and fairly present in all material respects such Credit Party’s consolidated financial condition and such Credit Party’s consolidated
results of operations. There has not been any material deterioration in any Credit Party’s consolidated financial condition since the date of the most recent financial statements submitted to the Administrative Agent. No Credit Party has any
contingent liability or liability for Taxes, long term lease (other than long-term leases entered into in the ordinary course of business) or unusual forward or long term commitment that is not reflected in the consolidated financial statements or
the notes thereto and which in any such case is material in relation to the business, operations, properties, assets, or condition (financial or otherwise) of any Credit Party taken as a whole. 

5.8. Solvency. As of the Effective Date, the fair salable value of each Credit Party’s assets (including goodwill
minus disposition costs) exceeds the fair value of its liabilities; no Credit Party is left with unreasonably small capital after the transactions in this Agreement, and each Credit Party is able to pay its debts (including trade debts) as they
mature. Without limiting the generality of the foregoing, as of the Effective Date, there has been no proposal made or resolution adopted by any competent corporate body for the dissolution or liquidation of any Credit Party, nor do any
circumstances exist which may result in the dissolution or liquidation of any Credit Party. As of the Effective Date, no proposal has been made nor any resolution been adopted by any competent corporate body of any Credit Party for the statutory
merger of such Credit Party with any other Person. As of the Effective Date, none of the Credit Parties has (i) made a general assignment for the benefit of creditors, (ii) filed any voluntary petition in bankruptcy or suffered the filing
of an involuntary petition by any creditor, (iii) suffered the appointment of a receiver to take possession of all or any portion of its assets, (iv) suffered the attachment or judicial seizure of all or any portion of its assets,
(v) admitted in writing its inability to pay its debts as they come due, nor (vi) made an offer of settlement, extension or composition to its creditors generally. 
 5.9. Payment of Taxes. All federal, material state, material provincial and other material Tax returns and reports (or extensions thereof) of each Credit Party and its Subsidiaries required
to be filed by any of them have been timely filed, and all Taxes reflected therein which are due and payable and all assessments, fees and other governmental charges upon any Credit Party and its Subsidiaries and upon their respective properties,
assets, income, businesses and franchises which are due and payable have been paid when due and payable. No Credit Party knows of any proposed Tax deficiency or assessment against it or any of its Subsidiaries which is not being actively contested
by it or such Subsidiary in good faith and by appropriate proceedings; provided, such reserves or other appropriate provisions, if any, as shall be required in conformity with Applicable Accounting Standards shall have been made or provided
therefor. Each Credit Party has paid all amounts necessary to fund all present pension, profit sharing and deferred compensation plans in accordance with their terms, and no Credit Party has withdrawn from participation in, and has not permitted
partial or complete termination of, or permitted the occurrence of any other event with respect to, any such plan which could reasonably be expected to result in any liability of such Credit Party, including any liability to the Pension Benefit
Guaranty Corporation or its successors or any other Governmental Authority. Neither any Credit Party nor any of its Subsidiaries have executed or filed with the Internal Revenue Service or any other Governmental Authority any agreement or other
document extending, or having the effect of extending, the period for assessment or collection of any Taxes nor has there been any request in writing for such extension. Neither any Credit Party nor any of its Subsidiaries has agreed or has been
requested to make any adjustment under IRC Section 481(a) by reason of a change in accounting method or otherwise. Neither any Credit Party nor any of its Subsidiaries has any obligation under any written tax sharing agreement. No Credit Party
nor any Subsidiary has been a member of an affiliated group filing a consolidated U.S. federal income tax return within the meaning of the Internal Revenue Code and has no liability for Taxes of any other Person under IRC Section 1.1502-6 (or
similar provision of foreign, state, or local law) as a transferee or successor, by contract, or otherwise. No Credit Party nor any Subsidiary has distributed stock of another Person, nor has had its stock distributed by another Person, in a
transaction that was purported or intended to be governed in whole or in part by IRC Sections 355 or 361 during any year for which the statute of limitations does not bar the assessment of U.S. federal income tax. 

  
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 5.10. Environmental Matters. No Credit Party nor any of its respective
Facilities or operations are subject to any outstanding written order, consent decree or settlement agreement with any Person relating to any Environmental Law, any Environmental Claim, or any Hazardous Materials Activity that, individually or in
the aggregate, could reasonably be expected to result in a Material Adverse Change. No Credit Party has received any letter or request for information under Section 104 of the Comprehensive Environmental Response, Compensation, and Liability
Act (42 U.S.C. § 9604) or any comparable state law. There are and, to each Credit Party’s knowledge, have been, no conditions, occurrences, or Hazardous Materials Activities which could reasonably be expected to form the basis of an
Environmental Claim against any Credit Party that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change. To any Credit Party’s knowledge, no predecessor of any Credit Party has filed any notice
under any Environmental Law indicating past or present treatment of Hazardous Materials at any Facility, and no Credit Party’s operations involves the generation, transportation, treatment, storage or disposal of hazardous waste, as defined
under 40 C.F.R. Parts 260 270 or any state equivalent. Compliance with all current or reasonably foreseeable future requirements pursuant to or under Environmental Laws could not be reasonably expected to result in, individually or in the aggregate,
a Material Adverse Change. No event or condition has occurred or is occurring with respect to any Credit Party relating to any Environmental Law, any Release of Hazardous Materials, or any Hazardous Materials Activity which individually or in the
aggregate has resulted in, or could reasonably be expected to result in, a Material Adverse Change. 
 5.11. Material
Contracts. Schedule 5.11 contains a true, correct and complete list of all the Material Contracts in effect on the Effective Date, and, after giving effect to consummation of the transactions contemplated by this Agreement, except as
described thereon, all such Material Contracts are in full force and effect and no defaults currently exist thereunder. 

5.12. Regulatory Compliance. No Credit Party is an “investment company” or a company “controlled” by an
“investment company” under the Investment Company Act of 1940, as amended. No Credit Party is engaged as one of its important activities in extending credit for margin stock (under Regulations X, T and U of the Federal Reserve Board). Each
Credit Party has complied in all material respects with the Federal Fair Labor Standards Act. No Credit Party nor any of its Included Subsidiaries is a “holding company” or an “affiliate” of a “holding company” or a
“subsidiary company” of a “holding company” as each term is defined and used in the Public Utility Holding Company Act of 2005. No Credit Party has violated any laws, ordinances or rules, the violation of which could reasonably
be expected to have a material adverse effect on its business. 
 5.13. Margin Stock. No Credit Party is engaged,
nor will it engage, principally or as one of its important activities, in the business of extending credit for the purpose of “purchasing” or “carrying” any “margin stock” as such terms are defined in Regulation U of
the Federal Reserve Board as now and from time to time hereafter in effect (such securities being referred to herein as (“Margin Stock”). No Credit Party owns any Margin Stock, and none of the proceeds of the Credit Extensions or
other extensions of credit under this Agreement will be used, directly or indirectly, for the purpose of purchasing or carrying any Margin Stock, for the purpose of reducing or retiring any Indebtedness that was originally incurred to purchase or
carry any Margin Stock or for any other purpose that might cause any of the Term Loans or other extensions of credit under this Agreement to be considered a “purpose credit” within the meaning of Regulations T, U or X of the Federal
Reserve Board. No Credit Party or any of its Included Subsidiaries will take or permit to be taken any action that might cause any Loan Document to violate any regulation of the Federal Reserve Board. 

5.14. Subsidiaries; Investments. No Credit Party owns any stock, partnership interest or other equity securities except for
Permitted Investments. 
 5.15. Employee Matters. No Credit Party is engaged in any unfair labor practice that could
reasonably be expected to result in a Material Adverse Change. There is (a) no unfair labor practice complaint pending against any Credit Party, or to the best knowledge of any Credit Party, threatened against any of them before the National
Labor Relations Board and no grievance or arbitration proceeding arising out of or under any collective bargaining agreement that is so pending against any Credit Party or to the best knowledge of any Credit Party, threatened against any of them,
(b) no strike or work stoppage in existence or threatened involving any Credit Party, and (c) to the best knowledge of any Credit Party, no union representation question existing with respect to the employees of any Credit Party and, to
the best knowledge of any Credit Party, no union organization activity that is taking place, except (with respect to any matter specified in clause (a), (b) or (c) above, either individually or in the aggregate) such as is not reasonably
likely to result in a Material Adverse Change. 

  
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 5.16. Use of Proceeds. Borrowers shall use the proceeds of the Credit
Extensions solely to repay the outstanding Indebtedness under the Existing Kreos/SVB Loan Agreement in full, to acquire by means of assignment €1,000,000 (EUROS) of the outstanding Indebtedness under the Existing Kreos Loan Agreement, and to
fund their general business requirements and not for personal, family, household or agricultural purposes. 
 5.17. Full
Disclosure. No representation or warranty of any Credit Party contained in any Loan Document or in any other documents, certificates or written statements furnished to the Administrative Agent or Lenders by or on behalf of any Credit
Party for use in connection with the transactions contemplated hereby contains any untrue statement of a material fact or omits to state a material fact (known to any Credit Party, in the case of any document not furnished by it) necessary in order
to make the statements contained herein or therein not misleading in light of the circumstances in which the same were made. Any projections and pro forma financial information contained in such materials are based upon good faith estimates and
assumptions believed by the Credit Party furnishing such materials to be reasonable at the time made. There are no facts known (or which should upon the reasonable exercise of diligence be known) to any Credit Party (other than matters of a general
economic nature) that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change and that have not been disclosed herein or in such other documents, certificates and statements furnished to Lenders for use
in connection with the transactions contemplated hereby. 
 5.18. Patriot Act. To the extent applicable, each
Credit Party is in compliance, in all material respects, with the (i) Trading with the Enemy Act, as amended, and each of the foreign assets control regulations of the Untied States Treasury Department (31 CFR, Subtitle B, Chapter V, as
amended) and any other enabling legislation or executive order relating thereto, and (ii) Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism (USA Patriot Act of 2001). No part of the
proceeds of the Credit Extensions will be used, directly or indirectly, for any payments to any governmental official or employee, political party, official of a political party, candidate for political office, or anyone else acting in an official
capacity, in order to obtain, retain or direct business or obtain any improper advantage, in violation of the United States Foreign Corrupt Practices Act of 1977, as amended. 
 5.19. Additional Representations and Warranties. The transactions contemplated by those agreements by and among the Credit Parties pursuant to which Horizon and Horizon AG became wholly
owned Subsidiaries of Horizon Pharma have been consummated in accordance with their respective terms without derivation and the respective representations and warranties of the Credit Parties contained therein are true, accurate, and complete in all
material respects on the Effective Date and on the Funding Date of each Credit Extension; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by
materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date. 

6. AFFIRMATIVE COVENANTS 
 Each Credit Party covenants and agrees that, until payment in full of all Obligations (other than inchoate indemnity obligations), each Credit Party shall, and shall cause each of its Subsidiaries (except
where otherwise provided below) to: 
 6.1. Government Compliance. Maintain its and all its Subsidiaries’
legal existence and good standing in their respective jurisdictions of formation and maintain qualification in each jurisdiction in which the failure to so qualify would reasonably be expected to result in a Material Adverse Change. Each Credit
Party shall comply, and cause each of its Subsidiaries to comply, with all laws, ordinances and regulations to which it is subject, noncompliance with which could reasonably be expected to result in a Material Adverse Change. 

6.2. Financial Statements, Reports, Certificates. Deliver to the Administrative Agent and each Lender: 

(a) Prior to Completion of an IPO. In the event that no Credit Party is subject to the reporting requirements under the Exchange
Act: 

  
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 (i) Monthly Financial Statements. As soon as available, but in no event later than
the earlier of (A) the date on which they are first delivered to the Board or members of management of Horizon Pharma or (B) thirty (30) days after the last day of each calendar month, (1) consolidated and consolidating balance
sheets and income statements of Horizon Pharma and its Subsidiaries, covering the operations of Horizon Pharma and its subsidiaries on a consolidated and consolidating basis for such month, in each case, certified by a Responsible Officer and in a
form acceptable to the Administrative Agent, (2) aged listings of accounts receivable and accounts payable (by invoice date), and (3) a statement with respect to each deposit, securities and commodity account of the Credit Parties showing
account balances as of the last day of the most recently completed calendar month (the “Monthly Financial Statements”); 
 (ii) Monthly Compliance Certificate. As soon as available, but in no event later than the earlier of (A) the date on which they are first delivered to the Board or members of management of
Horizon Pharma or (B) thirty (30) days after the last day of each calendar month, and together with the Monthly Financial Statements, a duly completed Compliance Certificate signed by a Responsible Officer, certifying that as of the end of
such month, each Credit Party was in full compliance with all of the terms and conditions of this Agreement; 
 (iii)
Quarterly Consolidated Financial Statements. As soon as available, but in no event later than the earlier of (i) the date on which they are first delivered to the Board or members of management of Horizon Pharma or (ii) thirty
(30) days after the last day of each calendar quarter, a Horizon Pharma prepared consolidated balance sheet and consolidating balance sheet as at the end of such period, and consolidated statements, with consolidating statements attached
thereto, of profit and loss, cash flow and change in stockholders equity of Horizon Pharma and its Subsidiaries for such quarterly period certified by a Responsible Officer and in a form acceptable to the Administrative Agent; 

(iv) Annual Audited Financial Statements. As soon as available, but in no event later than the earlier of (i) the date on
which they are first delivered to the Board or members of management of Horizon Pharma or (ii) one hundred eighty (180) days after the last day of Horizon Pharma’s fiscal year, commencing with the fiscal year ending December 31,
2010, audited consolidated financial statements prepared under Applicable Accounting Standards, consistently applied, together with an unqualified opinion (except as to going concern) on the financial statements from an independent certified public
accounting firm acceptable to the Administrative Agent in its reasonable discretion; 
 (b) After Completion of an IPO.
In the event that one or more of the Credit Parties is subject to the reporting requirements under the Exchange Act: 
 (i)
Monthly Financial Statements. As soon as available, but in no event later than the earlier of (A) the date on which they are first delivered to the Board or members of management of Horizon Pharma or (B) thirty (30) days after
the last day of each calendar month, (1) consolidated and consolidating balance sheets and income statements of Horizon Pharma and its Subsidiaries, covering the operations of Horizon Pharma and its Subsidiaries on a consolidated and
consolidating basis for such month, in each case, certified by a Responsible Officer and in a form acceptable to the Administrative Agent, and (2) aged listings of accounts receivable and accounts payable (by invoice date); 

(ii) Monthly Compliance Certificate. As soon as available, but in no event later than the earlier of (A) the date on which
they are first delivered to the Board or members of management of Horizon Pharma or (B) thirty (30) days after the last day of each calendar month, a duly completed Compliance Certificate signed by a Responsible Officer, certifying that as
of the end of such month, each Credit Party was in full compliance with all of the terms and conditions of this Agreement; 

(iii) Quarterly Consolidated Financial Statements. As soon as available, but in no event later than the earlier of (i) the
date on which they are first delivered to the Board or members of management of Horizon Pharma or (ii) forty-five (45) days after the last day of each calendar quarter, a Horizon Pharma prepared consolidated balance sheet and consolidating
balance sheet as at the end of such period, and consolidated statements, with consolidating statements attached thereto, of profit and loss, cash flow and change in stockholders equity of Horizon Pharma and its Subsidiaries for such quarterly period
certified by a Responsible Officer and in a form acceptable to the Administrative Agent; 

  
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 (c) Other Statements. Within five (5) days of delivery, copies of all
statements, reports and notices made available to Horizon Pharma’s security holders or to any holders of Subordinated Debt; 
 (d) SEC Filings. In the event that any Credit Party becomes subject to the reporting requirements under the Exchange Act within five (5) days of filing, copies of all periodic and other
reports, proxy statements and other materials filed by such Credit Party with the SEC, any Governmental Authority succeeding to any or all of the functions of the SEC or with any national securities exchange, or distributed to its shareholders, as
the case may be. Documents required to be delivered pursuant to the terms hereof (to the extent any such documents are included in materials otherwise filed with the SEC) may be delivered electronically and if so delivered, shall be deemed to have
been delivered on the date on which such Credit Party posts such documents, or provides a link thereto, on a website on the Internet at a website address provided to the Administrative Agent; 

(e) Legal Action Notice. A prompt report of any legal action pending or threatened in writing against any Credit Party that could
result in damages or costs to such Credit Party in an amount in excess of One Hundred Thousand Dollars ($100,000), individually, or Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when aggregated with all pending or threatened
legal actions against all Credit Parties; 
 (f) Board Approved Projections. (i) No later than ten (10) days
after the last day of Borrowers’ fiscal year, preliminary projections for the expected monthly operating expenses of Horizon AG and Horizon GmbH, on a consolidated basis, to be incurred in the ordinary course of business solely in connection
with Horizon AG’s LODOTRA program for the months of January, February and March of the current fiscal year as approved by Borrowers’ Board of Directors and in form and substance acceptable to the Administrative Agent, and (ii) within
five (5) days after approval thereof by Borrowers’ Board of Directors, but no later than ninety (90) days after the last day of Borrowers’ fiscal year, Borrowers’ financial projections for the entire current fiscal year
as approved by Borrowers’ Board of Directors, which such annual projections shall be set forth in a month-by-month format and shall include, on a month-by-month basis, projections for the expected monthly operating expenses of Horizon AG and
Horizon GmbH, on a consolidated basis, to be incurred in the ordinary course of business solely in connection with Horizon AG’s LODOTRA program during the current fiscal year, and be in form and substance acceptable to the Administrative Agent
(the foregoing projections as originally delivered to Collateral Agent and the Lenders are referred to herein as the “Annual Projections”); 
 (g) Bank statements. As soon as available, but no later than thirty (30) days after the last day of each month, copies of the month-end bank statements for each deposit account or securities
account maintained by Borrowers or any of their respective Included Subsidiaries, which bank statements may be provided to Administrative Agent by Borrowers or directly from the applicable bank(s); and 

(h) Other Financial Information. Other financial information reasonably requested by the Administrative Agent. 

6.3. Inventory; Returns; Maintenance of Properties. Keep all Inventory in good and marketable condition, free from material
defects. Returns and allowances between each Borrower and its Account Debtors shall follow such Borrower’s customary practices as they exist at the Effective Date. Each Credit Party must promptly notify the Administrative Agent of all returns,
recoveries, disputes and claims that involve more than One Hundred Thousand Dollars ($100,000), individually, or more than Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when aggregated with all other returns, recoveries,
disputes and claims. Each Credit Party will, and will cause each of its Included Subsidiaries to, maintain or cause to be maintained in good repair, working order and condition, ordinary wear and tear, casualty and condemnation excepted, all
material tangible properties used or useful in its respective business, and from time to time will make or cause to be made all appropriate repairs, renewals and replacements thereof. 

6.4. Taxes; Pensions. Timely file, and require each of its Subsidiaries to timely file, all required Tax returns and reports or
extensions therefor and timely pay, and require each of its Subsidiaries to timely pay, all foreign, federal, state and local Taxes, assessments, deposits and contributions imposed upon it or any of its properties or assets or in respect of any of
its income, businesses or franchises before any penalty or fine accrue thereon, and all claims (including claims for labor, services, materials and supplies) for sums that have become due and payable and that by law have or may become a Lien upon
any of its properties or assets, prior to the time when any penalty or fine shall be incurred with respect thereto; provided, no such Tax or claim need be paid if (i) such 

  
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Tax or claim does not exceed One Hundred Thousand Dollars ($100,000), individually, or more than Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when aggregated with all
other such Taxes or claims, or (ii) it is being contested in good faith by appropriate proceedings promptly instituted and diligently conducted, so long as (a) adequate reserve or other appropriate provision, as shall be required in
conformity with Applicable Accounting Standards shall have been made therefor, and (b) in the case of a Tax or claim which has or may become a Lien against any of the Collateral, such contest proceedings conclusively operate to stay the sale of
any portion of the Collateral to satisfy such Tax or claim. Each Credit Party shall deliver to the Administrative Agent, on demand, appropriate certificates attesting to any such payments, and pay all amounts necessary to fund all present pension,
profit sharing and deferred compensation plans in accordance with their terms. No Credit Party will, nor will it permit any of its Subsidiaries to, file or consent to the filing of any consolidated income Tax return with any Person (other than
Borrowers or any of their Subsidiaries). 
 6.5. Insurance. Maintain or cause to be maintained, with financially sound
and reputable insurers, such public liability insurance, third party property damage insurance, business interruption insurance and casualty insurance with respect to liabilities, losses or damage in respect of the assets, properties and businesses
of each Credit Party as may customarily be carried or maintained under similar circumstances by Persons of established reputation engaged in similar businesses, in each case in such amounts, with such deductibles, covering such risks and otherwise
on such terms and conditions as shall be customary for such Persons All property policies shall have a loss payable endorsement showing the Administrative Agent as loss payee and waive subrogation against the Administrative Agent and shall provide
that the insurer must give the Administrative Agent at least twenty (20) days notice before canceling, amending, or declining to renew its policy. All liability policies shall show, or have endorsements showing, the Administrative Agent as an
additional insured, and all such policies (or the loss payable and additional insured endorsements) shall provide that the insurer shall give the Administrative Agent at least twenty (20) days notice before canceling, amending, or declining to
renew its policy. At the Administrative Agent’s request, each Credit Party shall deliver certified copies of policies and evidence of all premium payments. If any Credit Party fails to obtain insurance as required under this
Section 6.5 or to pay any amount or furnish any required proof of payment to third persons and the Administrative Agent, the Administrative Agent may make all or part of such payment or obtain such insurance policies required in this
Section 6.5, and take any action under the policies the Administrative Agent deems prudent. 
 6.6. Operating
Accounts. 
 (a) Maintain all and all of its Included Subsidiaries’ operating, depository, and securities accounts with
Silicon Valley Bank or any of its Affiliates or, in respect of the Blocked Account, with the Royal Bank of Scotland plc or such other bank as may be agreed by the Administrative Agent. No Credit Party shall establish an operating, depository, or
securities account, other than any such accounts maintained at Silicon Valley Bank or any of its Affiliates, unless contemporaneously with such establishment, such account is subject to either (i) a Control Agreement or (ii) the grant to
the Administrative Agent, for the ratable benefit of the Lenders, of a security interest which has been perfected in accordance with applicable law, as applicable. 
 (b) Provide the Administrative Agent five (5) days prior written notice before establishing any Collateral Account at or with any bank or financial institution other than Silicon Valley Bank or any
of its Affiliates or, in respect of the Blocked Account, with the Royal Bank of Scotland plc. For each Collateral Account that each Credit Party at any time maintains, such Credit Party shall cause the applicable bank or financial institution (other
than the Administrative Agent) at or with which any Collateral Account is maintained to execute and deliver a Control Agreement or other appropriate instrument with respect to such Collateral Account to perfect the Administrative Agent’s Lien
in such Collateral Account in accordance with the terms hereunder or, in respect of Horizon UK, in accordance with the terms of the Supplemental Debenture, which Control Agreement or Supplemental Debenture may not be terminated without the prior
written consent of the Administrative Agent. The provisions of the previous sentence shall not apply to (i) deposit accounts exclusively used for payroll, payroll Taxes and other employee wage and benefit payments to or for the benefit of any
Credit Party’s employees and identified to the Administrative Agent by such Credit Party as such or (ii) the deposit account(s) securing Borrowers’ obligations to SVB with respect to its credit card program and other cash management
services or (iii) Borrowers’ lock-box account maintained at SVB provided that all monies in such lock-box account are swept daily to an account at SVB subject to a Control Agreement. 

6.7. Protection of Intellectual Property Rights. 

  
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 (a) (i) Protect, defend and maintain the validity and enforceability of its Intellectual
Property; (ii) promptly advise the Administrative Agent in writing of material infringements of its Intellectual Property; and (iii) not allow any Intellectual Property material to its business to be abandoned, forfeited or dedicated to
the public without the Administrative Agent’s written consent. 
 (b) Provide written notice to the Administrative Agent
within thirty (30) days of entering or becoming bound by any Restricted License (other than over-the-counter software that is commercially available to the public). Each Credit Party shall take such commercially reasonable steps as the
Administrative Agent requests to obtain the consent of, or waiver by, any person whose consent or waiver is necessary for (i) any Restricted License to be deemed “Collateral” and for the Administrative Agent to have a security
interest in it that might otherwise be restricted or prohibited by law or by the terms of any such Restricted License, whether now existing or entered into in the future, and (ii) the Administrative Agent to have the ability in the event of a
liquidation of any Collateral to dispose of such Collateral in accordance with the Administrative Agent’s rights and remedies under this Agreement and the other Loan Documents. 

6.8. Litigation Cooperation. From the date hereof and continuing through the termination of this Agreement, make available to the
Administrative Agent, without expense to the Administrative Agent, each Credit Party and its officers, employees and agents and such Credit Party’s books and records, to the extent that the Administrative Agent may deem them reasonably
necessary to prosecute or defend any third-party suit or proceeding instituted by or against the Administrative Agent with respect to any Collateral or relating to such Credit Party. 

6.9. Access to Collateral; Books and Records. Allow the Administrative Agent, or its agents, at reasonable times, on one
(1) Business Day’s notice (provided no notice is required if an Event of Default has occurred and is continuing), to inspect the Collateral and audit and copy any Credit Party’s Books. The foregoing inspections and audits shall be at
the relevant Credit Party’s expense. Such inspections or audits shall be conducted no more often than once every twelve (12) months unless an Event of Default has occurred and is continuing. 

6.10. Lenders Meetings. Upon the request of Administrative Agent or Required Lenders, participate in a meeting of
Administrative Agent and Lenders once during each fiscal year to be held at Borrowers’ corporate offices (or at such other location as may be agreed to by Borrowers and Administrative Agent) at such time as may be agreed to by Borrowers and
Administrative Agent. 
 6.11. Environmental. 
 (a) Environmental Disclosure; Deliver to Administrative Agent: 
 (i) as soon as practicable following receipt thereof, copies of all environmental audits, investigations, analyses and reports of any kind or character, whether prepared by personnel of any Credit Party
or by independent consultants, governmental authorities or any other Persons, with respect to significant environmental matters at any Facility or with respect to any material Environmental Claims; 

(ii) promptly upon an officer of any Credit Party obtaining knowledge of the occurrence thereof, written notice describing
in reasonable detail (1) any Release required to be reported to any federal, state or local governmental or regulatory agency under any applicable Environmental Laws, (2) any remedial action taken by any Credit Party or any other Person in
response to (A) any Hazardous Materials Activities the existence of which has a reasonable possibility of resulting in one or more Environmental Claims resulting in, individually or in the aggregate, a Material Adverse Change, or (B) any
Environmental Claims that, individually or in the aggregate, have a reasonable possibility of resulting in a Material Adverse Change, and (3) any Credit Party’s discovery of any occurrence or condition on any real property adjoining or in
the vicinity of any Facility that could cause such Facility or any part thereof to be subject to any material restrictions on the ownership, occupancy, transferability or use thereof under any Environmental Laws; 

(iii) as soon as practicable following the sending or receipt thereof by any Credit Party, a copy of any and all written
communications with respect to (1) any Environmental Claims that, individually or in the aggregate, have a reasonable possibility of resulting in a Material Adverse Change, 

  
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(2) any Release required to be reported to any federal, state or local governmental or regulatory agency, and (3) any request for information from any governmental agency that suggests such
agency is investigating whether any Credit Party or any of its Subsidiaries may be potentially responsible for any Hazardous Materials Activity that, individually or in the aggregate, has a reasonable possibility of resulting in a Material Adverse
Change; 
 (iv) prompt written notice describing in reasonable detail (1) any proposed acquisition of stock,
assets, or property by any Credit Party that could reasonably be expected to (A) expose any Credit Party to, or result in, Environmental Claims that could reasonably be expected to result in, individually or in the aggregate, a Material Adverse
Change or (B) affect the ability of any Credit Party to maintain in full force and effect all material Governmental Approvals required under any Environmental Laws for their respective operations and (2) any proposed action to be taken by
any Credit Party to modify current operations in a manner that could reasonably be expected to subject any Credit Party to any additional material obligations or requirements under any Environmental Laws; and 

(v) with reasonable promptness, such other documents and information as from time to time may be reasonably requested by
Administrative Agent in relation to any matters disclosed pursuant to this Section 6.11(a). 
 Each Credit Party
shall promptly take any and all actions necessary to (i) cure any violation of applicable Environmental Laws by such Credit Party that could reasonably be expected to result in, individually or in the aggregate, a Material Adverse Change, and
(ii) make an appropriate response to any Environmental Claim against such Credit Party and discharge any obligations it may have to any Person thereunder where failure to do so could reasonably be expected to result in, individually or in the
aggregate, a Material Adverse Change. 
 6.12. Further Assurances. At any time or from time to time upon the request of
the Administrative Agent, each Credit Party will, at its expense, promptly execute, acknowledge and deliver such further documents and do such other acts and things as the Administrative Agent may reasonably request in order to effect fully the
purposes of the Loan Documents. 
 6.13. Horizon AG Stock Pledge. Upon the repayment in full of the Existing Kreos
Loan Agreement, Horizon Pharma will execute and deliver to the Administrative Agent a share pledge agreement pledging to the Administrative Agent, for the benefit of the Lenders, a first priority Lien on the capital stock of Horizon AG representing
65% of the total combined voting power of all classes of stock entitled to vote the shares of capital stock of Horizon AG as security for the Obligations. 
 7. NEGATIVE COVENANTS 
 Each Credit Party covenants and agrees that,
until payment in full of all Obligations (other than inchoate indemnity obligations), such Credit Party shall not, and shall cause each of its Subsidiaries (except where otherwise provided below) not to: 

7.1. Dispositions. Convey, sell, lease, transfer, assign, or otherwise dispose of (collectively,
“Transfer”), or permit any of its Included Subsidiaries to Transfer, all or any part of its business or property, except (a) for Transfers of Inventory in the ordinary course of business; (b) for Transfers of worn out or
obsolete Equipment; (c) Permitted Licenses; and (d) in connection with Permitted Liens and Permitted Investments. Horizon AG shall not enter into any Royalty Finance Transaction without the consent of the Lenders as provided in
Section 7.4 below. 
 7.2. Changes in Business, Management, Ownership, or Business Locations.
(a) Engage in or permit any of its Subsidiaries to engage in any business other than the businesses currently engaged in by it and such Subsidiary, as applicable, or reasonably related thereto; (b) liquidate or dissolve; or
(c) (i) have a change in senior management and a replacement satisfactory to such Credit Party’s Board is not made within ninety (90) days after such person’s departure; or (ii) enter into any transaction or series of
related transactions in which the stockholders of any Credit Party who were not stockholders immediately prior to the first such transaction own more than 40% of the voting stock of such Credit Party immediately after giving effect to such
transaction or related series of such transactions (other than by the sale of such Credit Party’s equity securities in a public offering or to venture capital 

  
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investors so long as such Credit Party identifies to the Administrative Agent the venture capital investors prior to the closing of the transaction and provides to the Administrative Agent a
description of the material terms of the transaction). 
 No Credit Party shall, without at least thirty (30) days prior
written notice to the Administrative Agent: (1) add any new office or business location, including a warehouse (unless such new office or business location contains less than One Hundred Thousand Dollars ($100,000) in such Credit Party’s
assets or property ) or deliver any portion of the Collateral valued, individually in excess of One Hundred Thousand Dollars ($100,000) or, in the aggregate, in excess of Two Hundred and Fifty Thousand Dollars ($250,000) to a bailee at a location
other than to a bailee and at a location already disclosed in the Perfection Certificates, (2) change its jurisdiction of organization, (3) change its organizational structure or type, (4) change its legal name, or (5) change any
organizational number (if any) assigned by its jurisdiction of organization. If any Credit Party intends to deliver any portion of the Collateral valued, individually or in the aggregate, in excess of Two Hundred and Fifty Thousand ($250,000) to a
bailee, and the Administrative Agent and such bailee are not already parties to a bailee agreement governing both the Collateral and the location to which such Credit Party intends to deliver the Collateral, then such Credit Party will first receive
the written consent of the Administrative Agent, and such bailee shall execute and deliver a bailee agreement in form and substance reasonably satisfactory to the Administrative Agent. 

7.3. Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other
Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person. A Subsidiary may merge or consolidate into another Subsidiary (provided such surviving Subsidiary is a
“co-Borrower” hereunder or has provided a secured guaranty of Borrowers’ Obligations hereunder) or into a Borrower provided a Borrower is the surviving legal entity, and as long as no Event of Default is occurring prior thereto or
arises as a result therefrom. 
 7.4. Indebtedness. Directly or indirectly, create, incur, assume or guaranty, or
otherwise become or remain directly or indirectly liable with respect to any Indebtedness, other than Permitted Indebtedness. In the event the Lenders have declined to exercise their first right to provide Horizon AG with financing pursuant to a
Royalty Finance Transaction in accordance with Section 7.18 and Horizon AG proposes to enter into a Royalty Finance Transaction with a third party (a “Proposed Royalty Finance Transaction”), the Lenders agree that within five
(5) Business Days of receipt by the Lenders of (i) the final legal documentation relating to such Proposed Royalty Finance Transaction and (ii) pro forma financial information giving effect to such Proposed Royalty Finance Transaction
in form and substance reasonably acceptable to the Lenders, the Lenders will inform the Borrower whether or not the Lenders consent to Horizon AG entering into the Proposed Royalty Finance Transaction (which consent the Lenders may grant or withhold
in their sole and absolute discretion). 
 7.5. Encumbrance. Except for Permitted Liens, create, incur, allow, or suffer
any Lien on any of its property, or assign or convey any right to receive income, including the sale of any Accounts, or permit any of its Included Subsidiaries to do so, or permit any Collateral not to be subject to the first priority security
interest granted herein. Notwithstanding the foregoing, promptly following the receipt by the Administrative Agent of evidence reasonably satisfactory to the Administrative Agent of the achievement of the DUEXIS Sales Target, the restriction in the
foregoing sentence shall no longer apply with respect to the Intellectual Property Collateral; provided that the restriction contained in the foregoing sentence shall continue to apply with respect to the IP Collateral Proceeds. 

7.6. No Further Negative Pledges; Negative Pledge. 
 (a) Except with respect to (i) specific property encumbered by Permitted Liens to secure payment of Permitted Indebtedness, and (ii) restrictions by reason of customary provisions restricting
assignments, subletting or other transfers contained in leases, licenses and similar agreements entered into in the ordinary course of business (provided that such restrictions are limited to the property or assets secured by such Liens or the
property or assets subject to such leases, licenses or similar agreements, as the case may be), no Credit Party nor any of its Included Subsidiaries shall enter into any agreement prohibiting the creation or assumption of any Lien upon any of its
properties or assets, whether now owned or hereafter acquired. 
 (b) No Credit Party will sell, assign, transfer, exchange or
otherwise dispose of any Equity Interests issued by any Subsidiary which are owned or otherwise held by such Credit Party, except (i) pursuant to the Horizon AG Stock Pledge, (ii) any Lien or claim in favor of Administrative Agent, and
(iii) sales, assignments, 

  
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transfers, exchanges or other dispositions to another Credit Party or to qualify directors if required by applicable law; provided that, in the case of sales, assignments, transfers, exchanges or
other dispositions to qualify directors as required by applicable law, such sale, assignment, transfer, exchange or other disposition shall be for the minimum number of Equity Interests as are necessary for such qualification under applicable law.
No Credit Party will create, incur, assume or suffer to exist, any Lien on the Equity Interests issued by any Subsidiary which are owned or otherwise held by such Credit Party, except for (i) any Lien or claim in favor of Administrative Agent
and (ii) the pledge of the shares of Horizon AG pursuant to the Horizon AG Stock Pledge. 
 7.7. Maintenance of
Collateral Accounts. Maintain any Collateral Account except pursuant to the terms of Section 6.6 hereof. 

7.8. Distributions; Investments. (a) Pay any dividends or make any distribution or payment or redeem, retire or
purchase any capital stock; provided that (i) a Borrower may convert any of its convertible securities into other securities pursuant to the terms of such convertible securities or otherwise in exchange thereof, (ii) a Borrower may pay
dividends solely in common stock; and (iii) a Borrower may repurchase the stock of former employees, directors or consultants pursuant to stock repurchase agreements so long as (A) an Event of Default does not exist at the time of such
repurchase and would not exist after giving effect to such repurchase and (B) the amount paid for all such repurchases shall not exceed One Hundred Thousand Dollars ($100,000), in the aggregate, in any twelve (12) month period, or
(b) directly or indirectly make any Investment other than Permitted Investments, or permit any of its Included Subsidiaries to do so. Notwithstanding the foregoing, Horizon shall be permitted to pay dividends or make distributions to Horizon
Pharma, and Subsidiaries of the Borrowers shall be permitted to pay dividends or make distributions to the Borrowers. 
 7.9.
Restrictions on Subsidiary Distributions. Except pursuant to the Existing Kreos Loan Agreement, the Horizon AG Stock Pledge, the Horizon AG Intercompany Note, and the Additional Horizon AG Intercompany Note, create or otherwise cause or
suffer to exist or become effective any consensual encumbrance or restriction of any kind on the ability of any Subsidiary of Borrowers to (a) pay dividends or make any other distributions on any of such Subsidiary’s Equity Interests owned
by Borrowers or any other Subsidiary of Borrowers, (b) repay or prepay any Indebtedness owed by such Subsidiary to Borrowers or any other Subsidiary of Borrowers, (c) make loans or advances to Borrowers or any other Subsidiary of
Borrowers, or (d) transfer, lease or license any of its property or assets to Borrowers or any other Subsidiary of Borrowers other than restrictions (i) by reason of customary provisions restricting assignments, subletting or other
transfers contained in leases, licenses, joint venture agreements and similar agreements entered into in the ordinary course of business, (ii) that are or were created by virtue of any transfer of, agreement to transfer or option or right with
respect to any property, assets or Equity Interests not otherwise prohibited under this Agreement that impose restrictions on such Equity Interests or assets or (iii) that exist under or by reason of applicable law. 

7.10. Disposal of Subsidiary Interests. Except for the Horizon AG Stock Pledge and Liens arising under this Agreement and the
other Loan Documents, directly or indirectly sell, assign, pledge or otherwise encumber or dispose of any Equity Interests of any of its Subsidiaries, except to qualify directors if required by applicable law. 

7.11. Transactions with Affiliates. Directly or indirectly enter into or permit to exist any material transaction with any
Affiliate of any Credit Party, except for (a) transactions that are in the ordinary course of such Credit Party’s business, upon fair and reasonable terms that are no less favorable to such Credit Party than would be obtained in an
arm’s length transaction with a non-affiliated Person, (b) Investments permitted under sub-clauses (f) or (g) of the definition of Permitted Investments, and (c) Investments in Horizon Pharma comprised of the proceeds of
equity financings and unsecured debt financings from Horizon Pharma’s investors, so long as all such Indebtedness is Subordinated Debt. 
 7.12. Subordinated Debt. (a) Make or permit any payment on any Subordinated Debt, except under the terms of the subordination, intercreditor, or other similar agreement to which such
Subordinated Debt is subject, or (b) amend any provision in any document relating to the Subordinated Debt which would increase the amount thereof, except under the terms of the subordination, intercreditor, or other similar agreement to which
such Subordinated Debt is subject, or adversely affect the subordination thereof to Obligations owed to the Lenders. 

  
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 7.13. Amendments or Waivers of Organizational Documents. Agree to any amendment,
restatement, supplement or other modification to, or waiver of, any of its Operating Documents in a manner that would adversely affect its ability to perform its obligations under the Loan Documents or adversely affect the rights, remedies and
benefits available to, or conferred upon, the Administrative Agent or any Lender under any Loan Document. 
 7.14. Fiscal
Year. No Credit Party shall, nor shall it permit any of its Subsidiaries to change its fiscal year; provided, that after the Effective Date, Horizon GmbH may change its fiscal year from a fiscal year ending on June 30 to a fiscal year
ending on December 31. 
 7.15. Compliance. Become an “investment company” or a company controlled by an
“investment company”, under the Investment Company Act of 1940, as amended, or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in Regulation U of the Board of Governors of the
Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA, permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; fail to comply with
the Federal Fair Labor Standards Act or violate any other law or regulation, if the violation could reasonably be expected to have a material adverse effect on its business, or permit any of its Included Subsidiaries to do so; withdraw or permit any
Included Subsidiary to withdraw from participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any present pension, profit sharing and deferred compensation plan which could reasonably
be expected to result in any liability of such Credit Party, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency. 

7.16. Non-Guarantor Subsidiaries. No Credit Party shall permit the assets (excluding intercompany receivables and $100,000 in cash
in the aggregate) of any of its Subsidiaries (other than (x) Horizon AG and (y) Horizon GmbH to the extent the assets of Horizon GmbH do not exceed One Million Dollars ($1,000,000) in the aggregate) to exceed Fifty Thousand Dollars
($50,000), unless and until such Subsidiary (a) is or becomes a co-borrower or a guarantor hereunder and (b) has granted to the Administrative Agent, for the ratable benefit of the Lenders, a security interest in all of its assets, which
security interest has been perfected in accordance with applicable law. 
 7.17. Compliance with Anti-Terrorism Laws.

 Administrative Agent hereby notifies each Credit Party that pursuant to the requirements of Anti-Terrorism Laws, and
Administrative Agent’s policies and practices, Administrative Agent is required to obtain, verify and record certain information and documentation that identifies each Credit Party and its principals, which information includes the name and
address of each Credit Party and its principals and such other information that will allow Administrative Agent to identify such party in accordance with Anti-Terrorism Laws. No Credit Party will, nor will any Credit Party permit any Subsidiary or
Affiliate to, directly or indirectly, knowingly enter into any documents, instruments, agreements or contracts with any Person listed on the OFAC Lists. Each Credit Party shall immediately notify Administrative Agent if any Credit Party has
knowledge that any Credit Party or any Subsidiary or Affiliate is listed on the OFAC Lists or (a) is convicted on, (b) pleads nolo contendere to, (c) is indicted on, or (d) is arraigned and held over on charges involving
money laundering or predicate crimes to money laundering. No Credit Party will, nor will any Credit Party permit any Subsidiary or Affiliate to, directly or indirectly, (i) conduct any business or engage in any transaction or dealing with any
Blocked Person, including, without limitation, the making or receiving of any contribution of funds, goods or services to or for the benefit of any Blocked Person, (ii) deal in, or otherwise engage in any transaction relating to, any property
or interests in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law, or (iii) engage in or conspire to engage in any transaction that evades or avoids, or has the purpose of
evading or avoiding, or attempts to violate, any of the prohibitions set forth in Executive Order No. 13224 or other Anti-Terrorism Law. 
 7.18. Existing Kreos Loan Agreement/Horizon AG Indebtedness. The Borrowers shall not (i) permit Horizon AG to make any payment in respect of the Indebtedness under the Existing Kreos Loan
Agreement except regularly scheduled payments of principal and interest when due and reimbursement of the fees and expenses of Kreos to the extent permitted by the terms of the Existing Kreos Loan Agreement and (ii) permit Horizon AG to
refinance the Existing Kreos Loan Agreement or incur any other Indebtedness to Kreos other than pursuant to the Existing Kreos Loan Agreement or incur any other Indebtedness for borrowed money (including, without limitation,

  
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the incurrence of any obligations pursuant to any royalty finance transaction (including, without limitation any royalty finance transaction involving (A) the Transfer, License and Supply
Agreement between Merck Pharma GmbH and Horizon AG and Horizon Pharma GmbH dated December 19, 2006, as amended, and the Transfer, License and Supply Agreement between Merck GesmbH and Horizon AG and Horizon Pharma GmbH dated March 26,
2009, as amended and (B) the Exclusive Distribution Agreement between Horizon AG and Mundipharma International Corporation Limited dated March 24, 2009, as amended, and the Manufacturing and Supply Agreement between Horizon AG and
Mundipharma Medical Company dated March 26, 2009 (a “Royalty Finance Transaction”)) without providing the Lenders the first right to provide such refinancing or Indebtedness fifteen (15) days prior to the time that
requests are made to other financing sources. Should the Lender and the Borrowers fail to agree on the terms and conditions of such refinancing or Indebtedness within fifteen (15) days, then Borrower may seek to obtain such financing from
funding sources other than the Lenders (it being understood that the incurrence of such Indebtedness shall be subject to the terms of Section 7.4). The Lenders acknowledge that the foregoing is subject to a previous right granted to Kreos
pursuant to the Existing Kreos Loan Agreement. 
 7.19. Intercompany Notes. For so long as any Obligations remain
outstanding, Horizon Pharma shall not release, forgive, waive or permit Horizon AG to set-off against any Indebtedness of Horizon AG under the Horizon AG Intercompany Note or the Additional Horizon AG Intercompany Note, or swap or otherwise convert
any Indebtedness of Horizon AG under the Horizon AG Intercompany Note or the Additional Horizon AG Intercompany Note for equity capital of Horizon AG or any other asset. 
 8. [RESERVED]. 
 9. EVENTS OF DEFAULT 

Any one of the following shall constitute an event of default (an “Event of Default”) under this Agreement: 

9.1. Payment Default. Any Credit Party fails to (a) make any payment of principal or interest on any Credit Extension on its
due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable (which three (3) Business Day cure period shall not apply to payments due on the Term Loan Maturity Date or the date
of acceleration pursuant to Section 10.1 (a) hereof). During the cure period, the failure to make or pay any payment specified under clause (a) or (b) hereunder is not an Event of Default (but no Credit Extension will be made
during the cure period); 
 9.2. Covenant Default. 

(a) The Credit Parties fail or neglect to perform any obligation in Sections 6.2, 6.4, 6.5, 6.6,
6.7(b), or violate any covenant in Section 7; or 
 (b) The Credit Parties fail or neglect to perform, keep,
or observe any other term, provision, condition, covenant or agreement contained in this Agreement or any Loan Documents, and as to any default (other than those specified elsewhere in this Section 9) under such other term, provision,
condition, covenant or agreement that can be cured, have failed to cure the default within ten (10) days after the occurrence thereof; provided, however, that if the default cannot by its nature be cured within the ten (10) day period or
cannot after diligent attempts by the Credit Parties be cured within such ten (10) day period, and such default is likely to be cured within a reasonable time, then the Credit Parties shall have an additional period (which shall not in any case
exceed thirty (30) days) to attempt to cure such default, and within such reasonable time period the failure to cure the default shall not be deemed an Event of Default (but no Credit Extensions shall be made during such cure period). Cure
periods provided under this section shall not apply, among other things, to financial covenants or any other covenants set forth in clause (a) above; 
 9.3. Material Adverse Change. A Material Adverse Change occurs; 
 9.4.
Attachment; Levy; Restraint on Business. 
 (a) (i) The service of process seeking to attach, by trustee or similar process,
any funds of any Credit Party or of any entity under the control of any Credit Party (including a Subsidiary) on deposit or 

  
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otherwise maintained with any Lender or any Lender’s Affiliate, or (ii) a notice of lien or levy is filed against any Credit Party’s assets by any government agency, and the same
under subclauses (i) and (ii) hereof are not, within ten (10) days after the occurrence thereof, discharged or stayed (whether through the posting of a bond or otherwise); provided, however, no Credit Extensions shall be made during
any ten (10) day cure period; or 
 (b) (i) Any material portion of any Credit Party’s assets is attached, seized,
levied on, or comes into possession of a trustee or receiver, or (ii) any court order enjoins, restrains, or prevents any Credit Party from conducting any material part of its business; 

9.5. Insolvency. (a) Any Credit Party is unable to pay its debts (including trade debts) as they become due or otherwise
becomes insolvent; (b) any Credit Party begins an Insolvency Proceeding; or (c) an Insolvency Proceeding is begun against any Credit Party and not dismissed or stayed within thirty (30) days (but no Credit Extensions shall be made
while of any of the conditions described in clause (a) exist and/or until any Insolvency Proceeding is dismissed); 

9.6. Other Agreements. There is under any agreement to which a Credit Party is a party with a third party or parties, (i) any
default resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of Two Hundred and Fifty Thousand Dollars ($250,000), individually, or in excess of Five
Hundred Thousand Dollars ($500,000), when aggregated with all other defaults by Credit Parties under agreements with third parties, or (ii) any default by any Credit Party, the result of which could have a material adverse effect on such Credit
Party’s business or assets; 
 9.7. Judgements. One or more final judgments, orders, or decrees for the payment of
money in an amount in excess of Two Hundred and Fifty Thousand Dollars ($250,000), individually, or in excess of Five Hundred Thousand Dollars ($500,000), when aggregated with all other final judgments, orders, or decrees for the payment of money
(but excluding any final judgments, orders, or decrees for the payment of money that are covered by independent third-party insurance as to which liability has been accepted by such insurance carrier), shall be rendered against one or more Credit
Parties and the same are not, within ten (10) days after the entry thereof, discharged or execution thereof stayed or bonded pending appeal, or such judgments are not discharged prior to the expiration of any such stay (provided that no Credit
Extensions will be made prior to the discharge, stay, or bonding of such judgment, order, or decree); 
 9.8.
Misrepresentations. Any Credit Party or any Person acting for any Credit Party makes any representation, warranty, or other statement now or later in this Agreement, any Loan Document or in any writing delivered to the Administrative Agent
and/or any Lender or to induce the Administrative Agent and/or any Lender to enter this Agreement or any Loan Document, and such representation, warranty, or other statement is incorrect in any material respect when made; 

9.9. Subordinated Debt. Any document, instrument, or agreement evidencing any Subordinated Debt shall for any reason be revoked or
invalidated or otherwise cease to be in full force and effect, any Person shall be in breach thereof or contest in any manner the validity or enforceability thereof or deny that it has any further liability or obligation thereunder, or the
Obligations shall for any reason be subordinated or shall not have the priority contemplated by this Agreement; or 
 9.10.
Existing Kreos Loan Agreement. The occurrence of an event of default under the Existing Kreos Loan Agreement. 
 10.
RIGHTS AND REMEDIES UPON AN EVENT OF DEFAULT 
 10.1. Rights and Remedies. While an Event of Default occurs and
continues the Administrative Agent may, without notice or demand, do any or all of the following: 
 (a) declare all Obligations
immediately due and payable (but if an Event of Default described in Section 9.5 occurs all Obligations are immediately due and payable without any action by the Administrative Agent); 

  
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 (b) stop advancing money or extending credit for Borrowers’ benefit under this
Agreement or under any other agreement between Borrowers and the Administrative Agent; 
 (c) settle or adjust disputes and
claims directly with Account Debtors for amounts on terms and in any order that the Administrative Agent considers advisable, notify any Person owing Borrowers money of the Administrative Agent’s security interest in such funds, and verify the
amount of such account; 
 (d) make any payments and do any acts it considers necessary or reasonable to protect the Collateral
and/or its security interest in the Collateral. Borrowers shall assemble the Collateral if the Administrative Agent requests and make it available as the Administrative Agent designates. Administrative Agent may enter premises where the Collateral
is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its security interest and pay all expenses incurred. Borrowers grant Administrative
Agent a license to enter and occupy any of their premises, without charge, to exercise any of Administrative Agent’s rights or remedies; 
 (e) apply to the Obligations (i) any balances and deposits of Borrowers it holds, or (ii) any amount held by Administrative Agent owing to or for the credit or the account of Borrowers;

 (f) ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell the Collateral.
Administrative Agent is hereby granted a non-exclusive, royalty-free license or other right to use, without charge, Borrowers’ labels, Patents, Copyrights, mask works, rights of use of any name, trade secrets, trade names, Trademarks, and
advertising matter, or any similar property as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in connection with Administrative Agent’s exercise of its rights under this
Section, Borrowers’ rights under all licenses and all franchise agreements inure to Administrative Agent’s benefit; 

(g) place a “hold” on any account maintained with Administrative Agent and/or deliver a notice of exclusive control, any
entitlement order, or other directions or instructions pursuant to any Control Agreement or similar agreements providing control of any Collateral; 
 (h) demand and receive possession of Borrowers’ Books; and 
 (i) exercise all
rights and remedies available to Administrative Agent and/or any Lender under the Loan Documents or at law or equity, including all remedies provided under the Code (including disposal of the Collateral pursuant to the terms thereof). 

10.2. Power of Attorney. Each Borrower hereby irrevocably appoints Administrative Agent as its lawful attorney-in-fact,
exercisable upon the occurrence and during the continuance of an Event of Default, to: (a) endorse Borrower’s name on any checks or other forms of payment or security; (b) sign Borrower’s name on any invoice or bill of lading for
any Account or drafts against Account Debtors; (c) settle and adjust disputes and claims about the Accounts directly with Account Debtors, for amounts and on terms Administrative Agent determines reasonable; (d) make, settle, and adjust
all claims under Borrower’s insurance policies; (e) pay, contest or settle any Lien, charge, encumbrance, security interest, and adverse claim in or to the Collateral, or any judgment based thereon, or otherwise take any action to
terminate or discharge the same; and (f) transfer the Collateral into the name of Administrative Agent or a third party as the Code permits. Each Borrower hereby appoints Administrative Agent as its lawful attorney-in-fact to sign
Borrower’s name on any documents necessary to perfect or continue the perfection of Administrative Agent’s security interest in the Collateral regardless of whether an Event of Default has occurred until all Obligations (other than
inchoate indemnity obligations) have been satisfied in full and Administrative Agent is under no further obligation to make Credit Extensions hereunder. Administrative Agent’s foregoing appointment as each Borrower’s attorney in fact, and
all of Administrative Agent’s rights and powers, coupled with an interest, are irrevocable until all Obligations (other than inchoate indemnity obligations) have been fully repaid and performed and each Lender’s obligation to provide
Credit Extensions terminates. 
 10.3. Protective Payments. If Borrowers fail to obtain the insurance called for by
Section 6.5 or fail to pay any premium thereon or fail to pay any other amount which Borrowers are obligated to pay under this Agreement or any other Loan Document, Administrative Agent may obtain such insurance or make such payment, and
all amounts so paid by Administrative Agent are Lender Expenses and immediately due and payable, bearing 

  
 - 25 -

 
interest at the then highest rate applicable to the Obligations, and secured by the Collateral. Administrative Agent will make reasonable efforts to provide Borrowers with notice of
Administrative Agent obtaining such insurance at the time it is obtained or within a reasonable time thereafter. No payments by Administrative Agent are deemed an agreement to make similar payments in the future or Administrative Agent’s waiver
of any Event of Default. 
 10.4. Application of Payments and Proceeds Upon Default. If an Event of Default has occurred
and is continuing, Administrative Agent may apply any funds in its possession, whether from Borrower account balances, payments, proceeds realized as the result of any collection of Accounts or other disposition of the Collateral, or otherwise, to
the Obligations in such order as Administrative Agent shall determine in its sole discretion. Any surplus shall be paid to Borrowers or other Persons legally entitled thereto; Borrowers shall remain liable to Administrative Agent for any deficiency.
If Administrative Agent, in its good faith business judgment, directly or indirectly enters into a deferred payment or other credit transaction with any purchaser at any sale of Collateral, Administrative Agent shall have the option, exercisable at
any time, of either reducing the Obligations by the principal amount of the purchase price or deferring the reduction of the Obligations until the actual receipt by Administrative Agent of cash therefor. 

10.5. Administrative Agent’s Liability for Collateral. So long as Administrative Agent complies with reasonable banking
practices regarding the safekeeping of the Collateral in the possession or under the control of Administrative Agent, Administrative Agent shall not be liable or responsible for: (a) the safekeeping of the Collateral; (b) any loss or
damage to the Collateral; (c) any diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or other Person. Borrowers bear all risk of loss, damage or destruction of the Collateral.

 10.6. No Waiver; Remedies Cumulative. Administrative Agent’s failure, at any time or times, to require strict
performance by Borrowers of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Administrative Agent thereafter to demand strict performance and compliance herewith or therewith. No waiver
hereunder shall be effective unless signed by the party granting the waiver and then is only effective for the specific instance and purpose for which it is given. Administrative Agent’s rights and remedies under this Agreement and the other
Loan Documents are cumulative. Administrative Agent has all rights and remedies provided under the Code, by law, or in equity. Administrative Agent’s exercise of one right or remedy is not an election and shall not preclude Administrative Agent
from exercising any other remedy under this Agreement or other remedy available at law or in equity, and Administrative Agent’s waiver of any Event of Default is not a continuing waiver. Administrative Agent’s delay in exercising any
remedy is not a waiver, election, or acquiescence. 
 10.7. Demand Waiver. Borrowers waive demand, notice of default or
dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees held by Administrative Agent on
which Borrowers are liable. 
 11. ADMINISTRATIVE AGENT 

11.1. Appointment of Administrative Agent. Oxford is hereby appointed Administrative Agent hereunder and under the other Loan
Documents and each Lender hereby authorizes Oxford to act as Administrative Agent in accordance with the terms hereof and the other Loan Documents. The Administrative Agent hereby agrees to act in its capacity as such upon the express conditions
contained herein and the other Loan Documents, as applicable. The provisions of this Section 11 are solely for the benefit of the Administrative Agent and Lenders and no Credit Party shall have any rights as a third party beneficiary of
any of the provisions thereof. Except as otherwise provided in Section 2.8(b), in performing its functions and duties hereunder, the Administrative Agent shall act solely as an agent of Lenders and does not assume and shall not be deemed
to have assumed any obligation towards or relationship of agency or trust with or for Borrowers or any of their Subsidiaries. 

11.2. Powers and Duties. Each Lender irrevocably authorizes the Administrative Agent to take such action on such Lender’s
behalf and to exercise such powers, rights and remedies hereunder and under the other Loan Documents as are specifically delegated or granted to the Administrative Agent by the terms hereof and thereof, together with such powers, rights and remedies
as are reasonably incidental thereto. The Administrative Agent shall have only those duties and responsibilities that are expressly specified herein and the other Loan Documents and no 

  
 - 26 -

 
implied duties or responsibilities shall be read into this Agreement against the Administrative Agent. The Administrative Agent may exercise such powers, rights and remedies and perform such
duties by or through its agents or employees. The Administrative Agent shall not have, by reason hereof or any of the other Loan Documents, a fiduciary relationship in respect of any Lender; and nothing herein or any of the other Loan Documents,
expressed or implied, is intended to or shall be so construed as to impose upon the Administrative Agent any obligations in respect hereof or any of the other Loan Documents except as expressly set forth herein or therein. 

11.3. General Immunity. 
 (a) No Responsibility for Certain Matters. The Administrative Agent shall not be responsible to any Lender for the execution, effectiveness, genuineness, validity, enforceability, collectability or
sufficiency hereof or any other Loan Document or for any representations, warranties, recitals or statements made herein or therein or made in any written or oral statements or in any financial or other statements, instruments, reports or
certificates or any other documents furnished or made by the Administrative Agent to the Lenders or by or on behalf of any Credit Party or any Lender in connection with the Loan Documents and the transactions contemplated thereby or for the
financial condition or business affairs of any Credit Party or any other Person liable for the payment of any Obligations, nor shall the Administrative Agent be required to ascertain or inquire as to the performance or observance of any of the
terms, conditions, provisions, covenants or agreements contained in any of the Loan Documents or as to the existence or possible existence of any Event of Default or Default or to make any disclosures with respect to the foregoing. Anything
contained herein to the contrary notwithstanding, the Administrative Agent shall not have any liability arising from confirmations of the amount of outstanding Term Loans or the component amounts thereof. 

(b) Exculpatory Provisions. The Administrative Agent and any of its officers, partners, directors, employees or agents shall not
be liable to the Lenders for any action taken or omitted by the Administrative Agent under or in connection with any of the Loan Documents except to the extent caused by the Administrative Agent’s gross negligence or willful misconduct, as
determined by a final, non-appealable judgment of a court of competent jurisdiction. The Administrative Agent shall be entitled to refrain from any act or the taking of any action (including the failure to take an action) in connection herewith or
any of the other Loan Documents or from the exercise of any power, discretion or authority vested in it hereunder or thereunder unless and until the Administrative Agent shall have received instructions in respect thereof from Required Lenders (or
such other Lenders as may be required to give such instructions under Section 14.5) and, upon receipt of such instructions from Required Lenders (or such other Lenders, as the case may be), the Administrative Agent shall be entitled to
act or (where so instructed) refrain from acting, or to exercise such power, discretion or authority, in accordance with such instructions. The Administrative Agent may distribute documents, deliverables or other materials to the Lenders for
acceptance or rejection, and may, upon appropriate notice, rely on the lack of an objection by Lenders as a deemed approval of the action presented. Without prejudice to the generality of the foregoing, (i) the Administrative Agent shall be
entitled to rely, and shall be fully protected in relying, upon any communication, instrument or document believed by it to be genuine and correct and to have been signed or sent by the proper Person or Persons and shall be entitled to rely and
shall be protected in relying on opinions and judgments of attorneys (who may be attorneys for Borrowers and their Subsidiaries), accountants, experts and other professional advisors selected by it; and (ii) no Lender shall have any right of
action whatsoever against the Administrative Agent as a result of the Administrative Agent acting or (where so instructed) refraining from acting hereunder or any of the other Loan Documents in accordance with the instructions of Required Lenders
(or such other Lenders as may be required to give such instructions under Section 14.5). 
 (c) Delegation of
Duties. The Administrative Agent may perform any and all of its duties and exercise its rights and powers under this Agreement or under any other Loan Document by or through any one or more sub-agents appointed by the Administrative Agent. The
Administrative Agent and any such sub-agent may perform any and all of its duties and exercise its rights and powers by or through their respective Affiliates. The exculpatory, indemnification and other provisions of this Section 11.3
and of Section 11.6 shall apply to any of the Affiliates of the Administrative Agents, and shall apply to their respective activities as Administrative Agent. All of the rights, benefits, and privileges (including the exculpatory and
indemnification provisions) of this Section 11.3 and of Section 11.6 shall apply to any such sub-agent and to the Affiliates of any such sub-agent, and shall apply to their respective activities as sub-agent as if such
sub-agent and Affiliates were named herein. Notwithstanding anything herein to the contrary, with respect to each sub-agent appointed by the Administrative Agent, (i) such sub-agent 

  
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shall be a third party beneficiary under this Agreement with respect to all such rights, benefits and privileges (including exculpatory rights and rights to indemnification) and shall have all of
the rights and benefits of a third party beneficiary, including an independent right of action to enforce such rights, benefits and privileges (including exculpatory rights and rights to indemnification) directly, without the consent or joinder of
any other Person, against any or all of the Credit Parties and the Lenders, (ii) such rights, benefits and privileges (including exculpatory rights and rights to indemnification) shall not be modified or amended without the consent of such
sub-agent, and (iii) such sub-agent shall only have obligations to the Administrative Agent, and not to any Credit Party, Lender or any other Person and no Credit Party, Lender or any other Person shall have any rights, directly or indirectly,
as a third party beneficiary or otherwise, against such sub-agent. 
 11.4. Administrative Agent Entitled to Act as
Lender. The agency hereby created shall in no way impair or affect any of the rights and powers of, or impose any duties or obligations upon, the Administrative Agent in its individual capacity as a Lender hereunder. With respect to its
participation in the Term Loans, the Administrative Agent shall have the same rights and powers hereunder as any other Lender and may exercise the same as if it were not performing the duties and functions delegated to it hereunder, and the term
“Lender” shall, unless the context clearly otherwise indicates, include the Administrative Agent in its individual capacity. The Administrative Agent and its respective Affiliates may accept deposits from, lend money to, own securities of,
and generally engage in any kind of banking, trust, financial advisory or other business with Borrowers or any of their Affiliates as if it were not performing the duties specified herein, and may accept fees and other consideration from Borrowers
for services in connection herewith and otherwise without having to account for the same to Lenders. 
 11.5. Lenders’
Representations, Warranties and Acknowledgment. 
 (a) Each Lender represents and warrants that it has made its own
independent investigation of the financial condition and affairs of Borrowers and their Subsidiaries in connection with Credit Extensions hereunder and that it has made and shall continue to make its own appraisal of the creditworthiness of
Borrowers and their Subsidiaries. The Administrative Agent shall not have any duty or responsibility, either initially or on a continuing basis, to make any such investigation or any such appraisal on behalf of Lenders or to provide any Lender with
any credit or other information with respect thereto, whether coming into its possession before the making of the Term Loans or at any time or times thereafter, and the Administrative Agent shall not have any responsibility with respect to the
accuracy of or the completeness of any information provided to Lenders. 
 (b) Each Lender on the Effective Date shall be deemed
to have acknowledged receipt of, and consented to and approved, each Loan Document and each other document required to be approved by the Administrative Agent, Required Lenders or Lenders, as applicable on the Effective Date. 

11.6. Right to Indemnity. Each Lender, in proportion to its Pro Rata Share, severally agrees to indemnify the Administrative
Agent, to the extent that the Administrative Agent shall not have been reimbursed by any Credit Party, for and against any and all liabilities, obligations, losses, damages, penalties, actions, judgments, suits, costs, expenses (including counsel
fees and disbursements) or disbursements of any kind or nature whatsoever which may be imposed on, incurred by or asserted against the Administrative Agent in exercising its powers, rights and remedies or performing its duties hereunder or under the
other Loan Documents or otherwise in its capacity as the Administrative Agent in any way relating to or arising out of this Agreement or the other Loan Documents; provided, no Lender shall be liable for any portion of such liabilities, obligations,
losses, damages, penalties, actions, judgments, suits, costs, expenses or disbursements resulting from the Administrative Agent’s gross negligence or willful misconduct, as determined by a final, non-appealable judgment of a court of competent
jurisdiction. If any indemnity furnished to the Administrative Agent for any purpose shall, in the opinion of the Administrative Agent, be insufficient or become impaired, the Administrative Agent may call for additional indemnity and cease, or not
commence, to do the acts indemnified against until such additional indemnity is furnished; provided, in no event shall this sentence require any Lender to indemnify the Administrative Agent against any liability, obligation, loss, damage, penalty,
action, judgment, suit, cost, expense or disbursement in excess of such Lender’s Pro Rata Share thereof; and provided further, this sentence shall not be deemed to require any Lender to indemnify the Administrative Agent against any liability,
obligation, loss, damage, penalty, action, judgment, suit, cost, expense or disbursement described in the proviso in the immediately preceding sentence. 
 11.7. Successor Administrative Agent. The Administrative Agent may resign at any time by giving thirty days’ prior written notice thereof to Lenders and Borrowers, and the Administrative Agent
may be removed at 

  
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any time with or without cause by an instrument or concurrent instruments in writing delivered to Borrowers and the Administrative Agent and signed by Required Lenders. Upon any such notice of
resignation or any such removal, Required Lenders shall have the right, upon five Business Days’ notice to Borrowers, to appoint a successor Administrative Agent. Upon the acceptance of any appointment as Administrative Agent hereunder by a
successor Administrative Agent, that successor Administrative Agent shall thereupon succeed to and become vested with all the rights, powers, privileges and duties of the resigning or removed Administrative Agent and the resigning or removed
Administrative Agent shall promptly transfer to such successor Administrative Agent all sums, together with all records and other documents necessary or appropriate in connection with the performance of the duties of the successor Administrative
Agent under the Loan Documents. If the Required Lenders have not appointed a successor Administrative Agent, the Administrative Agent shall have the right to appoint a financial institution to act as Administrative Agent hereunder and in any case,
the Administrative Agent’s resignation shall become effective on the thirtieth day after such notice of resignation. If neither the Required Lenders nor the Administrative Agent have appointed a successor Administrative Agent, the Required
Lenders shall be deemed to succeeded to and become vested with all the rights, powers, privileges and duties of the resigning Administrative Agent. After any resigning or removed Administrative Agent’s resignation or removal hereunder as
Administrative Agent, the provisions of this Section 11 shall inure to its benefit as to any actions taken or omitted to be taken by it while it was Administrative Agent hereunder. 

11.8. Collateral Documents and Guaranty. 
 (a) Administrative Agent under Collateral Documents and Guaranty. Each Lender hereby further authorizes the Administrative Agent, on behalf of and for the benefit of Lenders, to be the agent for
and representative of the Lenders with respect to any guaranty, the Collateral and the Collateral Documents. Subject to Section 14.5, without further written consent or authorization from any Lenders, the Administrative Agent shall, at
the request and expense of Credit Parties, execute any documents or instruments necessary to, (i) in connection with a sale or disposition of assets permitted by this Agreement, release any Lien encumbering any item of Collateral that is the
subject of such sale or other disposition of assets or to which Required Lenders (or such other Lenders as may be required to give such consent under Section 14.5) have otherwise consented or (ii) release any Guarantor from any
guaranty or with respect to which Required Lenders (or such other Lenders as may be required to give such consent under Section 14.5) have otherwise consented. 
 (b) Right to Realize on Collateral and Enforce Guaranty. Anything contained in any of the Loan Documents to the contrary notwithstanding, each Credit Party, the Administrative Agent and each Lender
hereby agree that (i) no Lender shall have any right individually to realize upon any of the Collateral or to enforce the Guaranty, it being understood and agreed that all powers, rights and remedies hereunder may be exercised solely by the
Administrative Agent, on behalf of the Lenders in accordance with the terms hereof and all powers, rights and remedies under the Collateral Documents may be exercised solely by the Administrative Agent, and (ii) in the event of a foreclosure by
the Administrative Agent on any of the Collateral pursuant to a public or private sale or other disposition, the Administrative Agent or any Lender may be the purchaser or licensor of any or all of such Collateral at any such sale or other
disposition and the Administrative Agent, as agent for and representative of the Lenders (but not any Lender or Lenders in its or their respective individual capacities unless Required Lenders shall otherwise agree in writing) shall be entitled, for
the purpose of bidding and making settlement or payment of the purchase price for all or any portion of the Collateral sold at any such public sale, to use and apply any of the Obligations as a credit on account of the purchase price for any
collateral payable by the Administrative Agent at such sale or other disposition. 
 11.9. Withholding Taxes. 

To the extent required by any applicable law, the Administrative Agent may withhold from any payment to any Lender an amount equivalent
to any applicable withholding Tax. If the Internal Revenue Service or any other Governmental Authority asserts a claim that the Administrative Agent did not properly withhold Tax from amounts paid to or for the account of any Lender because the
appropriate form was not delivered or was not properly executed or because such Lender failed to notify the Administrative Agent of a change in circumstance which rendered the exemption from, or reduction of, withholding Tax ineffective or for any
other reason, such Lender shall indemnify the Administrative Agent fully for all amounts paid, directly or indirectly, by the 

  
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Administrative Agent as Tax or otherwise, including any penalties or interest and together with all expenses (including legal expenses, allocated internal costs and out-of-pocket expenses)
incurred. 
 12. NOTICES 
 All notices, consents, requests, approvals, demands, or other communication by any party to this Agreement or any other Loan Document must be in writing and shall be deemed to have been validly served,
given, or delivered: (a) upon the earlier of actual receipt and three (3) Business Days after deposit in the U.S. mail, first class, registered or certified mail return receipt requested, with proper postage prepaid; (b) upon
transmission, when sent by electronic mail or facsimile transmission; (c) one (1) Business Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if hand-delivered by messenger, all of
which shall be addressed to the party to be notified and sent to the address, facsimile number, or email address (if any) indicated below. Any Lender or Credit Party may change its mailing or electronic mail address or facsimile number by giving all
other parties hereto written notice thereof in accordance with the terms of this Section 12. 
  

			
	If to Borrowers:	    	 c/o Horizon Pharma USA, Inc.

1033 Skokie Boulevard, Suite 355
 Northbrook,
Illinois 60062
 Attn: Timothy P. Walbert

Fax: (847) 572-1372
 Email:
twalbert@horizonpharma.com

		
	with a copy to:	    	 Cooley LLP
 4401 Eastgate
Mall
 San Diego, California 92121

Attn: Barbara Borden, Esq. and Kay Chandler, Esq.

Fax: (858) 550-6420
 Email: bordenbl@cooley.com
and kchandler@cooley.com

		
	If to Administrative	    	
	Administrative Agent:	    	 Oxford Finance LLC
 133 North
Fairfax Street
 Alexandria, Virginia 22314
 Attention: General Counsel
 Fax: (703) 519-5225

		
	with a copy to:	    	 Riemer & Braunstein LLP

Three Center Plaza
 Boston, Massachusetts
02108
 Attn: John J. Malloy, Esquire

Fax: (617) 880-3449
 Email:
jmalloy@riemerlaw.com

		
	If to Lenders:	    	 Oxford Finance LLC
 133 North
Fairfax Street
 Alexandria, Virginia 22314
 Attention: General Counsel
 Fax: (703) 519-5225

		
	and:	    	 Silicon Valley Bank
 230 West
Monroe Street, Suite 720
 Chicago, Illinois 60606
 Attn: Kristen Parsons
 Fax: (312) 704-9512
 Email: kparsons@svb.com

  
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	with a copy to:	    	Riemer & Braunstein LLP
		    	 Three Center Plaza
 Boston,
Massachusetts 02108

		    	 Attn: John J. Malloy, Esquire

Fax: (617) 880-3449

		    	Email: jmalloy@riemerlaw.com

 13.
CHOICE OF LAW, VENUE, AND JURY TRIAL WAIVER 
 California law governs the Loan Documents without regard to principles
of conflicts of law. Credit Parties, the Administrative Agent and Lenders each submit to the exclusive jurisdiction of the State and Federal courts in Santa Clara County, California; provided, however, that nothing in this Agreement shall be deemed
to operate to preclude the Administrative Agent from bringing suit or taking other legal action in any other jurisdiction to realize on the Collateral or any other security for the Obligations, or to enforce a judgment or other court order in favor
of the Administrative Agent, for the ratable benefit if the Lenders. Each Credit Party expressly submits and consents in advance to such jurisdiction in any action or suit commenced in any such court, and each Credit Party hereby waives any
objection that it may have based upon lack of personal jurisdiction, improper venue, or forum non conveniens and hereby consents to the granting of such legal or equitable relief as is deemed appropriate by such court. Each Credit Party hereby
waives personal service of the summons, complaints, and other process issued in such action or suit and agrees that service of such summons, complaints, and other process may be made by registered or certified mail addressed to such Credit Party at
the address set forth in Section 12 of this Agreement and that service so made shall be deemed completed upon the earlier to occur of such Credit Party’s actual receipt thereof or three (3) days after deposit in the U.S. mails, proper
postage prepaid. 
 TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, CREDIT PARTIES, THE ADMINISTRATIVE AGENT, AND THE
LENDERS EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS
WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 
 WITHOUT INTENDING IN ANY WAY TO LIMIT THE PARTIES’ AGREEMENT TO WAIVE THEIR RESPECTIVE RIGHT TO A TRIAL BY JURY, if the above waiver of the right to a trial by jury is not enforceable, the parties
hereto agree that any and all disputes or controversies of any nature between them arising at any time shall be decided by a reference to a private judge, mutually selected by the parties (or, if they cannot agree, by the Presiding Judge of Santa
Clara County, California Superior Court) appointed in accordance with California Code of Civil Procedure Section 638 (or pursuant to comparable provisions of federal law if the dispute falls within the exclusive jurisdiction of the federal
courts), sitting without a jury, in Santa Clara County, California; and the parties hereby submit to the jurisdiction of such court. The reference proceedings shall be conducted pursuant to and in accordance with the provisions of California Code of
Civil Procedure §§ 638 through 645.1, inclusive. The private judge shall have the power, among others, to grant provisional relief, including without limitation, entering temporary restraining orders, issuing preliminary and permanent
injunctions and appointing receivers. All such proceedings shall be closed to the public and confidential and all records relating thereto shall be permanently sealed. If during the course of any dispute, a party desires to seek provisional relief,
but a judge has not been appointed at that point pursuant to the judicial reference procedures, then such party may apply to the Santa Clara County, California Superior Court for such relief. The proceeding before the private judge shall be
conducted in the same manner as it would be before a court under the rules of evidence applicable to judicial proceedings. The parties shall be entitled to discovery which shall be conducted in the same manner as it would be before a court under the
rules of discovery applicable to judicial proceedings. The private judge shall oversee discovery and may enforce all discovery rules and orders applicable to judicial proceedings in the same manner as a trial court judge. The parties agree that the
selected or appointed private judge shall have the power to decide all issues in the action or proceeding, whether of fact or of law, and shall report a statement of decision thereon pursuant to California Code of Civil Procedure § 644(a).
Nothing in this paragraph shall limit the right of any party at any time to exercise self-help 

  
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remedies, foreclose against collateral, or obtain provisional remedies. The private judge shall also determine all issues relating to the applicability, interpretation, and enforceability of this
paragraph. 
 14. GENERAL PROVISIONS 
 14.1. Successors and Assigns. This Agreement binds and is for the benefit of the successors and permitted assigns of each party. Borrowers may not transfer, pledge or assign this Agreement or any
rights or obligations under it without the Administrative Agent’s prior written consent (which may be granted or withheld in the Administrative Agent’s discretion, subject to Section 12.6). The Lenders have the right, without the
consent of or notice to Borrowers, to sell, transfer, assign, pledge, negotiate, or grant participation in (any such sale, transfer, assignment, negotiation, or grant of a participation, a “Lender Transfer”) all or any part of, or any
interest in, the Lenders’ obligations, rights, and benefits under this Agreement and the other Loan Documents provided, however, that any such Lender Transfer (other than a transfer, pledge, sale or assignment to an Eligible Assignee) of its
obligations, rights, and benefits under this Agreement and the other Loan Documents shall require the prior written consent of the Required Lenders (such approved assignee, an “Approved Lender”); provided further that provided no Event of
Default has occurred and is continuing, no Lender Transfer may be made to any direct or indirect competitor of Borrowers, or any Affiliate of a competitor of Borrowers or a vulture hedge fund, in each case as determined by the Administrative Agent
in its reasonable discretion, without Borrowers’ prior written consent. Borrowers and the Administrative Agent shall be entitled to continue to deal solely and directly with such Lender in connection with the interests so assigned until the
Administrative Agent shall have received and accepted an effective assignment agreement in form satisfactory to the Administrative Agent executed, delivered and fully completed by the applicable parties thereto, and shall have received such other
information regarding such Eligible Assignee or Approved Lender as the Administrative Agent reasonably shall require. 

14.2. Indemnification. 
 (a) Each Credit Party agrees to indemnify, defend, pay and hold harmless the Administrative Agent, each Lender and the directors, officers, employees, agents, attorneys, or any other Person affiliated
with or representing the Administrative Agent and each Lender (each, an “Indemnified Person”) from and against any and all Indemnified Liabilities; provided, (i) no Credit Party shall have any obligation to any Indemnified
Person hereunder with respect to any Indemnified Liabilities to the extent such Indemnified Liabilities arise from the gross negligence or willful misconduct of that Indemnified Person, in each case, as determined by a final, non-appealable judgment
of a court of competent jurisdiction, and (ii) no Credit Party shall be liable for any settlement of any claim or proceeding effected by any Indemnified Person without the prior written consent of such Credit Party (which consent shall not be
unreasonably withheld or delayed), but if settled with such consent or if there shall be a final judgment against an Indemnified Person, each of the Credit Parties shall indemnify and hold harmless such Indemnified Person from and against any loss
or liability by reason of such settlement or judgment in the manner set forth in this Agreement. 
 (b) To the extent permitted
by applicable law, no Credit Party shall assert, and each Credit Party hereby waives, any claim against each Lender, the Administrative Agent and their respective Affiliates, directors, employees, attorneys, agents or sub-agents, on any theory of
liability, for special, indirect, consequential or punitive damages (as opposed to direct or actual damages) (whether or not the claim therefor is based on contract, tort or duty imposed by any applicable legal requirement) arising out of, in
connection with, arising out of, as a result of, or in any way related to, this Agreement or any Loan Document or any agreement or instrument contemplated hereby or thereby or referred to herein or therein, the transactions contemplated hereby or
thereby, any Term Loan or the use of the proceeds thereof or any act or omission or event occurring in connection therewith, and each Credit Party hereby waives, releases and agrees not to sue upon any such claim or any such damages, whether or not
accrued and whether or not known or suspected to exist in its favor. 
 14.3. Severability of Provisions. In case any
provision in or obligation hereunder or under any other Loan Document shall be invalid, illegal or unenforceable in any jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or
obligation in any other jurisdiction, shall not in any way be affected or impaired thereby. 
 14.4. Correction of Loan
Documents. The Administrative Agent may correct patent errors and fill in any blanks in the Loan Documents consistent with the agreement of the parties so long as the Administrative Agent 

  
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provides Credit Parties with written notice of such correction and allows Credit Parties at least ten (10) days to object to such correction. In the event of such objection, such correction
shall not be made except by an amendment signed by the Administrative Agent, Required Lenders and Credit Parties. 
 14.5.
Amendments in Writing; Integration. (a) No amendment, modification, termination or waiver of any provision of this Agreement or any other Loan Document, no approval or consent thereunder, or any consent to any departure by the Borrowers
therefrom, shall in any event be effective unless the same shall be in writing and signed by the Borrowers, Administrative Agent and the Required Lenders provided that 
 (i) no such amendment, waiver or other modification that would have the effect of increasing or reducing a Lender’s Term Loan Commitment or Commitment Percentage shall be effective as to such Lender
without such Lender’s written consent; 
 (ii) no such amendment, waiver or modification that would affect the rights and
duties of Administrative Agent shall be effective without Administrative Agent’s written consent or signature; 
 (iii) no
such amendment, waiver or other modification shall, unless signed by all the Lenders directly affected thereby, (A) reduce the principal of, rate of interest on or any fees with respect to any Term Loan or forgive any principal, interest (other
than default interest) or fees (other than late charges) with respect to any Term Loan (B) postpone the date fixed for, or waive, any payment of principal of any Term Loan or of interest on any Term Loan (other than default interest) or any
fees provided for hereunder (other than late charges or for any termination of any commitment); (C) change the definition of the term “Required Lenders” or the percentage of Lenders which shall be required for Lenders to take any
action hereunder; (D) release all or substantially all or any material portion of the Collateral, authorize Borrower to sell or otherwise dispose of all or substantially all or any material portion of the Collateral or release any guarantor of
all or any portion of the Obligations or its guaranty obligations with respect thereto, except, in each case with respect to this clause (D), as otherwise may be expressly permitted under this Agreement or the other Loan Documents (including in
connection with any disposition permitted hereunder); (E) amend, waive or otherwise modify this Section 14.5 or the definitions of the terms used in this Section 14.5 insofar as the definitions affect the substance of this
Section 14.5; (F) consent to the assignment, delegation or other transfer by Borrowers of any of their rights and obligations under any Loan Document or release Borrowers of their payment obligations under any Loan Document, except, in
each case with respect to this clause (F), pursuant to a merger or consolidation permitted pursuant to this Agreement; (G) amend any of the provisions of Section 9.4 or amend any of the definitions Pro Rata Share, Term Loan Commitment,
Commitment Percentage or that provide for the Lenders to receive their Pro Rata Shares of any fees, payments, setoffs or proceeds of Collateral hereunder; (H) subordinate the Liens granted in favor of Administrative Agent securing the
Obligations; or (I) amend any of the provisions of Section 14.10. It is hereby understood and agreed that all Lenders shall be deemed directly affected by an amendment, waiver or other modification of the type described in the preceding
clauses (C), (D), (E), (F), (G) and (H) of the preceding sentence; 
 (iv) the provisions of the foregoing clauses
(i), (ii) and (iii) are subject to the provisions of any interlender or agency agreement among the Lenders and Administrative Agent pursuant to which any Lender may agree to give its consent in connection with any amendment, waiver or
modification of the Loan Documents only in the event of the unanimous agreement of all Lenders. 
 (b) Other than
as expressly provided for in Section 14.5(a)(i)-(iii), Administrative Agent may, if requested by the Required Lenders, from time to time designate covenants in this Agreement less restrictive by notification to a representative of
Borrower. 
 (c) This Agreement and the Loan Documents represent the entire agreement about this subject matter and supersede
prior negotiations or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Agreement and the Loan Documents merge into this Agreement and the Loan
Documents. 
 14.6. Counterparts. This Agreement may be executed in any number of counterparts and by different parties
on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Agreement. 

  
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 14.7. Survival. All covenants, representations and warranties made in this Agreement
continue in full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) have
been paid in full and satisfied. The obligation of Credit Parties in Section 14.2 to indemnify the Administrative Agent and the Lenders shall survive until the statute of limitations with respect to such claim or cause of action shall
have run. 
 14.8. Confidentiality. In handling any non-public information regarding Credit Parties and their
Subsidiaries and their businesses which would reasonably be expected to be confidential, the Administrative Agent and each Lender shall exercise the same degree of care that it exercises for its own proprietary information, but disclosure of
information may be made: (a) to any Lender’s Subsidiaries or Affiliates; (b) to prospective transferees or purchasers of any interest in the Credit Extensions (provided, however, each Lender shall use its best efforts to obtain any of
its prospective transferee’s or purchaser’s agreement to the terms of this provision); (c) as required by law, regulation, subpoena, or other order; (d) to any Lender’s regulators or as otherwise required in connection with
such Lender’s examination or audit; (e) as the Administrative Agent considers appropriate in exercising remedies under the Loan Documents; and (f) to third-party service providers of the Administrative Agent or any Lender so long as
such service providers have executed a confidentiality agreement with the Administrative Agent or Lender, as applicable, with terms no less restrictive than those contained herein. Confidential information does not include information that is
either: (i) in the public domain or in the Administrative Agent’s or in any Lender’s possession when disclosed to the Administrative Agent or to any Lender, or becomes part of the public domain after disclosure to the Administrative
Agent or any Lender other than as a result of a breach by the Administrative Agent or a Lender of the obligations under this Section 14.8; or (ii) disclosed to the Administrative Agent or any Lender by a third party if the
Administrative Agent or such Lender does not know that the third party is prohibited from disclosing the information. 
 Lenders
may use confidential information for the development of databases, reporting purposes, and market analysis so long as such confidential information is aggregated and anonymized prior to distribution unless otherwise expressly permitted by Credit
Parties. The provisions of the immediately preceding sentence shall survive the termination of this Agreement. 
 14.9.
Attorneys’ Fees, Costs and Expenses. In any action or proceeding between any Credit Party and Administrative Agent and/or any Lender arising out of or relating to the Loan Documents, the prevailing party shall be entitled to recover its
reasonable attorneys’ fees and other costs and expenses incurred, in addition to any other relief to which it may be entitled. 
 14.10. Right of Set-Off. In addition to any rights now or hereafter granted under applicable law and not by way of limitation of any such rights, upon the occurrence of an Event of Default and at
any time thereafter during the continuance of any Event of Default, each Lender is hereby authorized by each Credit Party at any time or from time to time subject to the consent of the Administrative Agent (such consent not to be unreasonably
withheld or delayed), without notice to any Credit Party or to any other Person (other than the Administrative Agent), any such notice being hereby expressly waived, to set off and to appropriate and to apply any and all deposits (general or
special, including Indebtedness evidenced by certificates of deposit, whether matured or unmatured, but not including trust accounts) and any other Indebtedness at any time held or owing by such Lender to or for the credit or the account of any
Credit Party against and on account of the obligations and liabilities of any Credit Party to such Lender hereunder and under the other Loan Documents, including all claims of any nature or description arising out of or connected hereto or with any
other Loan Document, irrespective of whether or not (a) such Lender shall have made any demand hereunder or (b) the principal of or the interest on the Term Loans or any other amounts due hereunder shall have become due and payable
pursuant to Section 2 and although such obligations and liabilities, or any of them, may be contingent or unmatured. 
 14.11. Marshalling; Payments Set Aside. Neither the Administrative Agent nor any Lender shall be under any obligation to marshal any assets in favor of any Credit Party or any other Person or
against or in payment of any or all of the Obligations. To the extent that any Credit Party makes a payment or payments to the Administrative Agent or Lenders (or to the Administrative Agent, on behalf of Lenders), or the Administrative Agent or
Lenders enforce any Liens or exercise their rights of setoff, and such payment or payments or the proceeds of such enforcement or setoff or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside and/or
required to be repaid to a trustee, receiver or any other party under any bankruptcy law, 

  
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any other state or federal law, common law or any equitable cause, then, to the extent of such recovery, the obligation or part thereof originally intended to be satisfied, and all Liens, rights
and remedies therefor or related thereto, shall be revived and continued in full force and effect as if such payment or payments had not been made or such enforcement or setoff had not occurred. 

14.12. Obligations Several; Independent Nature of Lenders’ Rights. The obligations of Lenders hereunder are several and no
Lender shall be responsible for the obligations or Term Commitment of any other Lender hereunder. Nothing contained herein or in any other Loan Document, and no action taken by Lenders pursuant hereto or thereto, shall be deemed to constitute
Lenders as a partnership, an association, a joint venture or any other kind of entity. The amounts payable at any time hereunder to each Lender shall be a separate and independent debt, and each Lender shall be entitled to protect and enforce its
rights arising out hereof and it shall not be necessary for any other Lender to be joined as an additional party in any proceeding for such purpose. 
 14.13. Electronic Execution of Documents. The words “execution,” “signed,” “signature” and words of like import in any Loan Document shall be deemed to include
electronic signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity and enforceability as a manually executed signature or the use of a paper-based recordkeeping systems, as the case may be,
to the extent and as provided for in any applicable law, including, without limitation, any state law based on the Uniform Electronic Transactions Act. 
 14.14. Captions. Section headings herein are included herein for convenience of reference only and shall not constitute a part hereof for any other purpose or be given any substantive effect.

 14.15. Construction of Agreement. The parties mutually acknowledge that they and their attorneys have participated in
the preparation and negotiation of this Agreement. In cases of uncertainty this Agreement shall be construed without regard to which of the parties caused the uncertainty to exist. 

14.16. Third Parties. Nothing in this Agreement, whether express or implied, is intended to: (a) confer any benefits, rights
or remedies under or by reason of this Agreement on any persons other than the express parties to it and their respective permitted successors and assigns; (b) relieve or discharge the obligation or liability of any person not an express party
to this Agreement; or (c) give any person not an express party to this Agreement any right of subrogation or action against any party to this Agreement. A person who is not a party to this Agreement has no rights under the UK Contracts (Rights
of Third Parties) Act 1999 to enforce or enjoy the benefit of this Agreement. 
 14.17. No Fiduciary Duty. The
Administrative Agent, each Lender and their respective Affiliates (collectively, solely for purposes of this paragraph, the “Lenders”), may have economic interests that conflict with those of the Credit Parties. Each Credit Party
agrees that nothing in the Loan Documents or otherwise will be deemed to create an advisory, fiduciary or agency relationship or fiduciary or other implied duty between the Lenders, on the one hand, and such Credit Party, its Subsidiaries, and any
of their respective stockholders or affiliates, on the other hand. Each Credit Party acknowledges and agrees that (i) the transactions contemplated by the Loan Documents are arm’s-length commercial transactions between the Lenders, on the
one hand, and such Credit Party, its Subsidiaries and their respective affiliates, on the other, (ii) in connection therewith and with the process leading to such transaction each of the Lenders is acting solely as a principal and not the agent
or fiduciary of such Credit Party, its Subsidiaries or their respective affiliates, management, stockholders, creditors or any other person, (iii) no Lender has assumed an advisory or fiduciary responsibility in favor of any Credit Party, its
Subsidiaries or their respective affiliates with respect to the transactions contemplated hereby or the process leading thereto (irrespective of whether any Lender or any of its affiliates has advised or is currently advising such Credit Party, its
Subsidiaries or their respective affiliates on other matters) or any other obligation to such Credit Party, its Subsidiaries or their respective affiliates except the obligations expressly set forth in the Loan Documents and (iv) each Credit
Party, its Subsidiaries and their respective affiliates have consulted their own legal and financial advisors to the extent each deemed appropriate. Each Credit Party further acknowledges and agrees that it is responsible for making its own
independent judgment with respect to such transactions and the process leading thereto. Each Credit Party agrees that it will not claim that any Lender has rendered advisory services of any nature or respect, or owes a fiduciary or similar duty to
such Credit Party, its Subsidiaries or their respective affiliates in connection with such transaction or the process leading thereto. 

  
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 14.18. Borrower Liability. Either Borrower may, acting singly, request Term Loans
hereunder. Each Borrower hereby appoints the other as agent for the other for all purposes hereunder, including with respect to requesting Term Loans hereunder. Each Borrower hereunder shall be jointly and severally obligated to repay all Term Loans
made hereunder, regardless of which Borrower actually receives said Term Loan, as if each Borrower hereunder directly received all Term Loans. Each Borrower waives (a) any suretyship defenses available to it under the Code or any other
applicable law, including, without limitation, the benefit of California Civil Code Section 2815 permitting revocation as to future transactions and the benefit of California Civil Code Sections 1432, 2809, 2810, 2819, 2839, 2845, 2847, 2848,
2849, 2850, and 2899 and 3433, and (b) any right to require the Administrative Agent or the Lenders to: (i) proceed against any other Borrower or any other person; (ii) proceed against or exhaust any security; or (iii) pursue any
other remedy. The Administrative Agent and the Lenders may exercise or not exercise any right or remedy it has against any Borrower or any security it holds (including the right to foreclose by judicial or non-judicial sale) without affecting any
other Borrower’s liability. Notwithstanding any other provision of this Agreement or other related document, each Borrower irrevocably waives all rights that it may have at law or in equity (including, without limitation, any law subrogating
Borrower to the rights of the Administrative Agent and the Lenders under this Agreement) to seek contribution, indemnification or any other form of reimbursement from any other Borrower, or any other Person now or hereafter primarily or secondarily
liable for any of the Obligations, for any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise and all rights that it might have to benefit from, or to participate in, any security for the
Obligations as a result of any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise. Any agreement providing for indemnification, reimbursement or any other arrangement prohibited under this Section
shall be null and void. If any payment is made to a Borrower in contravention of this Section, such Borrower shall hold such payment in trust for the Administrative Agent and the Lenders and such payment shall be promptly delivered to the
Administrative Agent for application to the Obligations, whether matured or unmatured. 
 15. DEFINITIONS

 15.1. Definitions. As used in the Loan Documents, the word “shall” is mandatory, the word “may”
is permissive, the word “or” is not exclusive, the words “includes” and “including” are not limiting, the singular includes the plural, and numbers denoting amounts that are set off in brackets are negative. As used in
this Agreement, the following capitalized terms have the following meanings: 
 “Account” is any
“account” as defined in the Code with such additions to such term as may hereafter be made, and includes, without limitation, all accounts receivable, book debts, and other sums owing to Credit Parties. 

“Account Debtor” is any “account debtor” as defined in the Code with such additions to such term as may
hereafter be made. 
 “Additional Horizon AG Intercompany Note” is defined in Section 3.1(t). 

“Administrative Agent” is defined in the preamble hereof. 

“Adverse Proceeding” means any action, suit, proceeding, hearing (whether administrative, judicial or otherwise),
governmental investigation or arbitration (whether or not purportedly on behalf of any Credit Party or any of its Subsidiaries) at law or in equity, or before or by any Governmental Authority, domestic or foreign (including any Environmental
Claims), whether pending or, to the knowledge of any Credit Party or any of its Subsidiaries, threatened against or adversely affecting any Credit Party or any of its Subsidiaries or any property of any Credit Party or any of its Subsidiaries.

 “Affiliate” is, with respect to any Person, each other Person that owns or controls directly or indirectly
the Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited liability company or limited
liability partnership, that Person’s managers and members. 
 “Agreement” is defined in the preamble
hereof. 
 “Amortization Date” is July 1, 2012. 

  
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 “Anti-Terrorism Laws” means any laws relating to terrorism or money
laundering, including Executive Order No. 13224 (effective September 24, 2001), the USA PATRIOT Act, the laws comprising or implementing the Bank Secrecy Act, and the laws administered by OFAC. 

“Applicable Accounting Standards” means (i) with respect to Horizon and Horizon Pharma, generally accepted
accounting principles in the United States as set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting
Standards Board or in such other statements by such other Person as may be approved by a significant segment of the accounting profession, which are applicable to the circumstances as of the date of determination, and (ii) with respect to
Horizon AG, Horizon GmbH and Horizon UK, the International Financial Reporting Standards. 
 “Approved Fund”
means any (i) investment company, fund, trust, securitization vehicle or conduit that is (or will be) engaged in making, purchasing, holding or otherwise investing in commercial loans and similar extensions of credit in the ordinary course of
its business or (ii) any Person (other than a natural person) which temporarily warehouses loans for any Lender or any entity described in the preceding clause (i) and that, with respect to each of the preceding clauses (i) and (ii),
is administered or managed by (a) a Lender, (b) an Affiliate of a Lender or (c) a Person (other than a natural person) or an Affiliate of a Person (other than a natural person) that administers or manages a Lender. 

“Approved Lender” has the meaning given it in Section 14.1. 

“Assignment Agreement” means an Assignment and Assumption Agreement in form reasonably satisfactory to the
Administrative Agent, with such amendments or modifications as may be approved by the Administrative Agent. 

“Bankruptcy Code” means Title 11 of the United States Code entitled “Bankruptcy,” as now and hereafter in
effect, or any successor statute. 
 “Basic Rate” means with respect to a Term Loan, the per annum rate of
interest (based on a year of 360 days) equal to the greater of (i) 11.50% and (ii) the sum of (a) the 90-day U.S. LIBOR rate reported in the Wall Street Journal three (3) Business Days prior to the Funding Date of such
Term Loan, plus (b) 10.25%. 
 “Blocked Account” shall have the meaning ascribed to it in the Supplemental
Debenture. 
 “Blocked Person” means (a) any Person listed in the annex to, or is otherwise subject to the
provisions of, Executive Order No. 13224, (b) a Person owned or controlled by, or acting for or on behalf of, any Person that is listed in the annex to, or is otherwise subject to the provisions of, Executive Order No. 13224,
(c) a Person with which any Lender is prohibited from dealing or otherwise engaging in any transaction by any Anti-Terrorism Law, (d) a Person that commits, threatens or conspires to commit or supports “terrorism” as defined in
Executive Order No. 13224, or (e) a Person that is named a “specially designated national” or “blocked person” on the most current list published by OFAC or other similar list. 

“Board” means a Credit Party’s board of directors. 

“Board of Governors” means the Board of Governors of the United States Federal Reserve System, or any successor thereto.

 “Books” are all books and records including ledgers, federal and state Tax returns, records regarding a
Credit Party’s assets or liabilities, the Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information. 

“Borrower” is defined in the preamble hereof. 
 “Borrowing Resolutions” are, with respect to any Person, those resolutions adopted by such Person’s Board and delivered by such Person to Administrative Agent approving the Loan
Documents to which such Person is a party and the transactions contemplated thereby, together with a certificate executed by its Secretary on behalf 

  
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of such Person certifying that (a) such Person has the authority to execute, deliver, and perform its obligations under each of the Loan Documents to which it is a party, (b) that
attached as Exhibit A to such certificate is a true, correct, and complete copy of the resolutions then in full force and effect authorizing and ratifying the execution, delivery, and performance by such Person of the Loan Documents to which it is a
party, (c) the name(s) of the Person(s) authorized to execute the Loan Documents on behalf of such Person, together with a sample of the true signature(s) of such Person(s), and (d) that Administrative Agent may conclusively rely on such
certificate unless and until such Person shall have delivered to Administrative Agent a further certificate canceling or amending such prior certificate. 
 “Business Day” is any day that is not a Saturday or a Sunday or a day on which banks are authorized or required to be closed in the City of San Francisco, California. 

“Cash Equivalents” means (a) marketable direct obligations issued or unconditionally guaranteed by the United
States or any agency or any State thereof having maturities of not more than one (1) year from the date of acquisition; (b) commercial paper maturing no more than one (1) year after its creation and having the highest rating from
either Standard & Poor’s Ratings Group or Moody’s Investors Service, Inc.; and (c) Silicon Valley Bank’s money market funds or certificates of deposit issued by Silicon Valley Bank maturing no more than one (1) year
after issue. Notwithstanding the foregoing, Cash Equivalents does not include and the Credit Parties and their Subsidiaries are prohibited from purchasing, purchasing participations in, entering into any type of swap or other equivalent derivative
transaction, or otherwise holding or engaging in any ownership interest in any type of debt instrument, including, without limitation, any corporate or municipal bonds with a long-term nominal maturity for which the interest rate is reset through a
dutch auction and more commonly referred to as an auction rate security. 
 “Charge over Shares” means the
Charge over Shares granted by Horizon in favor of the Administrative Agent as security trustee for the Lenders in respect of Horizon’s shares in Horizon UK. 
 “Code” is the Uniform Commercial Code, as the same may, from time to time, be enacted and in effect in the State of California; provided, that, to the extent that the Code is used to
define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such term contained in Article or Division 9 shall govern; provided further, that in the event
that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority of, or remedies with respect to, the Administrative Agent’s Lien on any Collateral is governed by the Uniform Commercial Code in effect in a
jurisdiction other than the State of California, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely for purposes of the provisions thereof relating to such attachment,
perfection, priority, or remedies and for purposes of definitions relating to such provisions. 
 “Collateral”
is (a) any and all properties, rights and assets of Credit Parties described on Exhibit A and (b) without limiting (a), with respect to Horizon UK, any property, assets, rights and interests of Horizon UK which are charged in favor
of the Administrative Agent (as security trustee for the Lenders) under or pursuant to the Debenture and the Supplemental Debenture. 
 “Collateral Account” is any Deposit Account, Securities Account, Commodity Account or Blocked Account. 
 “Collateral Documents” means all instruments, documents and agreements delivered by any Credit Party pursuant to this Agreement or any of the other Loan Documents, in each case in order
to grant to the Administrative Agent, for the benefit of Lenders, or perfect, a Lien on any real, personal or mixed property of that Credit Party as security for the Obligations. 

“Commodity Account” is any “commodity account” as defined in the Code with such additions to such term as may
hereafter be made. 
 “Compliance Certificate” is that certain certificate in the form attached hereto as
Exhibit C. 
 “Contingent Obligation” is, for any Person, any direct or indirect liability, contingent
or not, of that Person for (a) any indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation, in each case, directly or indirectly guaranteed, endorsed, co made, discounted or sold with recourse by
that Person, 

  
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or for which that Person is directly or indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all obligations from any interest
rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; but
“Contingent Obligation” does not include endorsements in the ordinary course of business. The amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if
not determinable, the maximum reasonably anticipated liability for it determined by the Person in good faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement. 

“Control Agreement” is any control agreement entered into among the depository institution at which a Credit Party
maintains a Deposit Account or the securities intermediary or commodity intermediary at which a Credit Party maintains a Securities Account or a Commodity Account, such Credit Party, and the Administrative Agent pursuant to which the Administrative
Agent obtains control (within the meaning of the Code) over such Deposit Account, Securities Account, or Commodity Account. 

“Copyrights” are any and all copyright rights, copyright applications, copyright registrations and like protections in
each work of authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret. 
 “Credit Extension” is any Term Loan or any other extension of credit by the Lenders for a Borrower’s benefit. 

“Credit Party” is each Borrower and each Guarantor. 

“Debenture” means the Debenture dated as of the Effective Date granted by Horizon UK in favor of the Administrative
Agent as security trustee for the Lenders, as amended, modified or restated from time to time.” 
 “Default
Excess” means, with respect to any Defaulting Lender, the excess, if any, of such Defaulting Lender’s Pro Rata Share of the aggregate outstanding principal amount of Term Loans of all Lenders (calculated as if all Defaulting Lenders
(including such Defaulting Lender) had funded all of their respective Defaulted Loans) over the aggregate outstanding principal amount of all Term Loans of such Defaulting Lender. 

“Default Period” means, with respect to any Defaulting Lender, the period commencing on the date of the applicable
Funding Default and ending on the earliest of the following dates: (i) the date on which all Term Commitments are cancelled or terminated and/or the Obligations are declared or become immediately due and payable, (ii) the date on which the
Default Excess with respect to such Defaulting Lender shall have been reduced to zero and (iii) the date on which Credit Parties, Administrative Agent and Required Lenders waive all Funding Defaults of such Defaulting Lender in writing.

 “Defaulted Loan” is defined in Section 2.7. 

“Defaulting Lender” is defined in Section 2.7. 

“Deposit Account” is any “deposit account” as defined in the Code with such additions to such term as may
hereafter be made. 
 “Designated Deposit Account” means account # 3300692916 maintained by Horizon Pharma at
SVB. 
 “Dollars,” “dollars” or use of the sign “$” means only lawful money
of the United States and not any other currency, regardless of whether that currency uses the “$” sign to denote its currency or may be readily converted into lawful money of the United States. 

“Draw Period” means the period commencing on the date Borrowers receive FDA approval for HZT-501 and ending on the
earlier to occur of (i) the occurrence of an Event of Default and (ii) June 3, 2011. 
 “Effective
Date” is defined in the preamble hereof. 

  
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 “Eligible Assignee” means (i) a Lender, (ii) an Affiliate of a
Lender, (iii) an Approved Fund and (iv) any commercial bank, savings and loan association or savings bank or any other entity which is an “accredited investor” (as defined in Regulation D under the Securities Act of 1933, as
amended) and which extends credit or buys loans as one of its businesses, including insurance companies, mutual funds, lease financing companies and commercial finance companies, in each case, which either (A) has a rating of BBB or higher from
Standard & Poor’s Rating Group and a rating of Baa2 or higher from Moody’s Investors Service, Inc. at the date that it becomes a Lender or (B) has total assets in excess of $5,000,000,000, and in each case of clauses
(i) through (iv), which, through its applicable lending office, is capable of lending to the Borrowers without the imposition of any withholding or similar taxes; provided that notwithstanding the foregoing, “Eligible Assignee” shall
not include (i) the Borrowers, any of the Borrowers’ Affiliates or Subsidiaries or (ii) unless an Event of Default has occurred and is continuing, a direct competitor of the Borrowers or a vulture hedge fund, each as determined by the
Administrative Agent in its reasonable discretion. Notwithstanding the foregoing, (x) in connection with assignments by a Lender due to a forced divestiture at the request of any regulatory agency, the restrictions set forth herein shall not
apply and Eligible Assignee shall mean any Person or party and (y) in connection with a Lender’s own financing or securitization transactions, the restrictions set forth herein shall not apply and Eligible Assignee shall mean any Person or
party providing such financing or formed to undertake such securitization transaction and any transferee of such Person or party upon the occurrence of a default, event of default or similar occurrence with respect to such financing or
securitization transaction; provided that no such sale, transfer, pledge or assignment under this clause (y) shall release such Lender from any of its obligations hereunder or substitute any such Person or party for such Lender as a party
hereto until the Administrative Agent shall have received and accepted an effective assignment agreement from such Person or party in form satisfactory to the Administrative Agent executed, delivered and fully completed by the applicable parties
thereto, and shall have received such other information regarding such Eligible Assignee as the Administrative Agent reasonably shall require. 
 “Environmental Claim” means any investigation, notice, notice of violation, claim, action, suit, proceeding, demand, abatement order or other order or directive (conditional or
otherwise), by any Governmental Authority or any other Person, arising (i) pursuant to or in connection with any actual or alleged violation of any Environmental Law; (ii) in connection with any Hazardous Material or any actual or alleged
Hazardous Materials Activity; or (iii) in connection with any actual or alleged damage, injury, threat or harm to health, safety, natural resources or the environment. 
 “Environmental Laws” means any and all current or future foreign or domestic, federal or state (or any subdivision of either of them), statutes, ordinances, orders, rules, regulations,
judgments, Governmental Approvals, or any other requirements of Governmental Authorities relating to (i) environmental matters, including those relating to any Hazardous Materials Activity; (ii) the generation, use, storage, transportation
or disposal of Hazardous Materials; or (iii) occupational safety and health, industrial hygiene, land use or the protection of human, plant or animal health or welfare, in any manner applicable to any Credit Party or any of its Subsidiaries or
any Facility. 
 “Equipment” is all “equipment” as defined in the Code with such additions to such
term as may hereafter be made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing. 

“Equity Interests” means any and all shares, interests, participations or other equivalents (however designated) of
capital stock of a corporation, any and all equivalent ownership interests in a Person (other than a corporation), including partnership interests and membership interests, and any and all warrants, rights or options to purchase or other
arrangements or rights to acquire any of the foregoing. 
 “ERISA” is the Employee Retirement Income Security
Act of 1974, and its regulations. 
 “Event of Default” is defined in Section 9. 

“Exchange Act” is the Securities Exchange Act of 1934, as amended from time to time, and any successor statute.

 “Existing Kreos Loan Agreement” means that certain Agreement for the Provision of a Loan Facility of up to
Euro 7,500,000, dated August 15, 2008, by and between Kreos Capital III (UK) Limited and Horizon AG, as in effect on the Effective Date. 

  
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 “Existing Kreos/SVB Loan Agreement” means that certain Loan and Security
Agreement, dated April 1, 2010, by and between Kreos Capital III (UK) Limited, as Administrative Agent, the Lenders party thereto, Horizon and Horizon AG as “Borrowers” and Horizon Pharma as “Guarantor”, as amended,
restated, or otherwise modified. 
 “Facility” means any real property (including all buildings, fixtures or
other improvements located thereon) now, hereafter or heretofore owned, leased, operated or used by any Credit Party or any of its Subsidiaries or any of their respective predecessors or Affiliates. 

“FDA” shall mean the Food and Drug Administration, any successor thereto, and any analogous Governmental Authority.

 “Federal Reserve Board” means the Board of Governors of the Federal Reserve System. 

“Final Payment” is a payment (in addition to and not a substitution for the regular monthly payments of principal plus
accrued interest) due on the earliest to occur of (a) the Term Loan Maturity Date, or (b) the acceleration of any Term Loan, or (c) the prepayment of a Term Loan pursuant to Section 2.2(c) or (d), equal to the original principal
amount of such Term Loan multiplied by the Final Payment Percentage, payable to Lenders in accordance with their respective Pro Rata Shares. 
 “Final Payment Percentage” is two percent (2.00%). 

“Funding Date” is any date on which a Credit Extension is made to or for the account of a Borrower which shall be a
Business Day. 
 “Funding Default” is defined in Section 2.7. 

“General Intangibles” is all “general intangibles” as defined in the Code in effect on the date hereof with
such additions to such term as may hereafter be made, and includes without limitation, all Intellectual Property, claims, income and other Tax refunds, security and other deposits, payment intangibles, contract rights, options to purchase or sell
real or personal property, rights in all litigation presently or hereafter pending (whether in contract, tort or otherwise), insurance policies (including without limitation key man, property damage, and business interruption insurance), payments of
insurance and rights to payment of any kind. 
 “Governmental Approval” is any consent, authorization,
approval, order, license, franchise, permit, certificate, accreditation, registration, filing or notice, of, issued by, from or to, or other act by or in respect of, any Governmental Authority. 

“Governmental Authority” is any nation or government, any state or other political subdivision thereof, any agency,
government department, authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative functions of or pertaining to government, any securities
exchange and any self-regulatory organization. 
 “Guarantor” is any present or future guarantor of the
Obligations. 
 “Hazardous Materials” means any chemical, material or substance, exposure to which is
prohibited, limited or regulated by any Governmental Authority or which may or could pose a hazard to the health and safety of the owners, occupants or any Persons in the vicinity of any Facility or to the indoor or outdoor environment. 

“Hazardous Materials Activity” means any past, current, proposed or threatened activity, event or occurrence involving
any Hazardous Materials, including the use, manufacture, possession, storage, holding, presence, existence, location, Release, threatened Release, discharge, placement, generation, transportation, processing, construction, treatment, abatement,
removal, remediation, disposal, disposition or handling of any Hazardous Materials, and any corrective action or response action with respect to any of the foregoing. 
 “Horizon” is defined in the preamble hereof. 
 “Horizon
AG” is Horizon Pharma AG, a company organized under the laws of Switzerland. 

  
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 “Horizon AG Stock Pledge” is defined in Section 3.1(n). 

“Horizon GmbH” is Horizon Pharma GmbH, a company organized under the laws of Germany. 

“Horizon AG Intercompany Note” is defined in Section 3.1(s). 

“Horizon UK” is Horizon Pharma (UK) Limited, a company organized under the laws of England and Wales. 

“Included Subsidiary” or “Included Subsidiaries” shall mean Subsidiaries other than Horizon AG and
Horizon GmbH. 
 “Indebtedness” is (a) indebtedness for borrowed money or the deferred price of property
or services, such as reimbursement and other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations, and (d) Contingent
Obligations. 
 “Indemnified Liabilities” means, collectively, any and all liabilities, obligations, losses,
damages (including natural resource damages), penalties, claims, actions, judgments, suits, costs, expenses and disbursements of any kind or nature whatsoever (including the reasonable fees and disbursements of counsel for Indemnified Persons in
connection with any investigative, administrative or judicial proceeding or hearing commenced or threatened by any Person, whether or not any such Indemnified Person shall be designated as a party or a potential party thereto (it being agreed that,
such counsel fees and expenses shall be limited to one primary counsel, and any additional special and local counsel in each appropriate jurisdiction, for the Indemnified Persons, except in the case of actual or potential conflicts of interest
between or among the Indemnified Persons), and any fees or expenses incurred by Indemnified Persons in enforcing this indemnity), whether direct, indirect or consequential and whether based on any federal, state or foreign laws, statutes, rules or
regulations, on common law or equitable cause or on contract or otherwise, that may be imposed on, incurred by, or asserted against any such Indemnified Person, in any manner relating to or arising out of this Agreement or the other Loan Documents
or the transactions contemplated hereby or thereby (including the Lenders’ agreement to make Credit Extensions or the use or intended use of the proceeds thereof, or any enforcement of any of the Loan Documents (including any sale of,
collection from, or other realization upon any of the Collateral or the enforcement of the Guaranty)). 
 “Indemnified
Person” is defined in Section 14.2. 
 “Insolvency Proceeding” is (a) any proceeding
by or against any Person under the United States Bankruptcy Code, or any other bankruptcy or insolvency law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking
reorganization, arrangement, or other relief or (b) a UK Insolvency Proceeding. 
 “Intellectual Property”
means all of Borrowers’ right, title, and interest in and to the following: 
 (a) its Copyrights, Trademarks and Patents;

 (b) any and all trade secrets and trade secret rights, including, without limitation, any rights to unpatented inventions,
know-how, operating manuals; 
 (c) any and all source code; 

(d) any and all design rights which may be available to a Borrower; 

(e) any and all claims for damages by way of past, present and future infringement of any of the foregoing, with the right, but not the
obligation, to sue for and collect such damages for said use or infringement of the Intellectual Property rights identified above; and 
 (f) all amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents. 

  
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 “Intellectual Property Collateral” means, as to each Credit Party, all of
such Credit Party’s right, title and interest in and to any Intellectual Property. 
 “Inventory” is all
“inventory” as defined in the Code in effect on the date hereof with such additions to such term as may hereafter be made, and includes without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials,
work in process and finished products, including without limitation such inventory as is temporarily out of a Credit Party’s custody or possession or in transit and including any returned goods and any documents of title representing any of the
above. 
 “Investment” is any beneficial ownership interest in any Person (including stock, partnership
interest or other securities), and any loan, advance or capital contribution to any Person. 
 “IP Agreements”
are those certain Intellectual Property Security Agreements entered into by and between Horizon and Horizon Pharma and Administrative Agent, each dated as of the Effective Date, as such may be amended from time to time. 

“IP Collateral Proceeds” means all Accounts, license and royalty fees and other revenues, proceeds or income arising out
of or relating to any of the Intellectual Property Collateral and any claims for damages by way of any past, present or future infringement of any of the Intellectual Property Collateral. 

“IRC” shall mean the Internal Revenue Code of 1986, as amended, and any successor thereto, and any regulations
promulgated thereunder. 
 “Knowledge,” to the “best of Credit Party’s knowledge” or
similar qualifications means the actual knowledge, after reasonable investigation, of the Responsible Officers. 

“Kreos” means Kreos Capital III (UK) Limited. 
 “Lender” and “Lenders” shall have the respective meanings set forth in the first paragraph of this Agreement and shall include any assignee or participant of a Loan in
accordance with Section 14.1 hereof. 
 “Lender Expenses” are all audit fees and expenses, costs,
and expenses (including reasonable attorneys’ fees and expenses) for preparing, amending, negotiating, administering, defending and enforcing the Loan Documents (including, without limitation, those incurred in connection with appeals or
Insolvency Proceedings) or otherwise incurred with respect to the Credit Parties. 
 “Lender Transfer” is
defined in Section 14.1. 
 “Lien” is a claim, mortgage, deed of trust, levy, charge, pledge,
security interest or other encumbrance of any kind, whether voluntarily incurred or arising by operation of law or otherwise against any property. 
 “Loan Documents” are, collectively, this Agreement, any Term Loan Notes, the IP Agreements, the Warrants, each Compliance Certificate, the Perfection Certificates, any Control Agreement,
any Collateral Document, any guaranties executed by a Credit Party, the Debenture, the Charge over Shares, and any other present or future agreement between a Credit Party and the Administrative Agent, in each case for the benefit of the Lenders, in
connection with this Agreement, all as amended, restated, or otherwise modified. 
 “Margin Stock” is defined
in Section 5.13. 
 “Material Adverse Change” is (a) a material impairment in the perfection
or priority of the Administrative Agent’s Lien in the Collateral or in the value of such Collateral, (b) a material adverse change in the business, operations, or condition (financial or otherwise) of Borrower, or (c) a material
impairment of the prospect of repayment of any portion of the Obligations. 
 “Material Contract” means any
contract or other arrangement to which a Credit Party or any of its Subsidiaries is a party (other than the Loan Documents) for which breach, nonperformance, cancellation or failure to renew could reasonably be expected to result in a Material
Adverse Change. 

  
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 “Monthly Financial Statements” is defined in Section 6.2(a)(i).

 “Non U.S. Lender” is defined in Section 2.7(c). 

“Obligations” are the Credit Parties’ obligations to pay when due any debts, principal, interest, Lender Expenses,
the Final Payment, the Prepayment Fee, and other amounts Credit Parties owe the Administrative Agent, for the ratable benefit of the Lenders, now or later, whether under this Agreement, the Loan Documents, or otherwise, including, without
limitation, all obligations relating to letters of credit (including reimbursement obligations for drawn and undrawn letters of credit), cash management services, and foreign exchange contracts, if any, and including interest accruing after
Insolvency Proceedings begin (whether or not allowed) and debts, liabilities, or obligations of Borrowers assigned to the Administrative Agent, for the ratable benefit of the Lenders, and to perform Borrowers’ duties under the Loan Documents;
provided that the term “Obligations” shall not include any obligations to pay or perform under any Warrant or any other warrant heretofore issued by Horizon Pharma to a Lender or an Affiliate of a Lender. 

“OFAC” is the U.S. Department of Treasury Office of Foreign Assets Control. 

“OFAC Lists” are, collectively, the Specially Designated Nationals and Blocked Persons List maintained by OFAC pursuant
to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) and/or any other list of terrorists or other restricted Persons maintained pursuant to any of the rules and regulations of OFAC or pursuant to any other applicable Executive
Orders. 
 “Operating Documents” are, for any Person, such Person’s formation documents, as certified with
the Secretary of State or other applicable Governmental Authority of such Person’s jurisdiction of formation on a date that is no earlier than 30 days prior to the Effective Date, and, (a) if such Person is a corporation, its bylaws in
current form, (b) if such Person is a limited liability company, its limited liability company agreement (or similar agreement), and (c) if such Person is a partnership, its partnership agreement (or similar agreement), each of the
foregoing with all current amendments or modifications thereto. 
 “Patents” means all patents, patent
applications and like protections including without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same. 
 “Patriot Act” is defined in Section 3.1(q). 

“Payment/Advance Form” is that certain form attached hereto as Exhibit B. 

“Payment Date” is the first day of each calendar month. 

“Perfection Certificate” is defined in Section 5.5. 

“Permitted Indebtedness” is: 
 (a) Credit Parties’ Indebtedness to the Lenders under this Agreement and the other Loan Documents; 
 (b) Indebtedness existing on the Effective Date and shown on Schedule 15.1 hereto; 
 (c) Subordinated Debt; 
 (d) unsecured Indebtedness to trade creditors incurred in
the ordinary course of business; 
 (e) Indebtedness incurred as a result of endorsing negotiable instruments received in the
ordinary course of business; 
 (f) Indebtedness secured by Liens permitted under clauses (a) and (c) of the
definition of “Permitted Liens” hereunder; 

  
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 (g) Indebtedness to SVB with respect to Borrowers’ credit card program and other cash
management services provided that the amount of such Indebtedness shall at no time exceed $200,000; 
 (h) Indebtedness of
Horizon AG pursuant to the Existing Kreos Loan Agreement; 
 (i) Indebtedness of Horizon AG pursuant to the Horizon AG
Intercompany Note and the Additional Horizon AG Intercompany Note; and 
 (j) extensions, refinancings, modifications,
amendments and restatements of any items of Permitted Indebtedness (a) through (f) above, provided that the principal amount thereof is not increased or the terms thereof are not modified to impose more burdensome terms upon any Credit
Party or its Subsidiaries, as the case may be. 
 “Permitted Investments” are: 

(a) Investments (including, without limitation, Subsidiaries) existing on the Effective Date and shown on Schedule 15.2 hereto;

 (b) Investments consisting of Cash Equivalents; 
 (c) Investments consisting of the endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of business; 

(d) Subject to Section 6.6, Investments consisting of deposit accounts or securities accounts; 

(e) Investments accepted in connection with Permitted Licenses; 
 (f) (i) Investments by any Credit Party in or to any other Credit Party, (ii) Investments by Borrowers in the Horizon AG Intercompany Note and the Additional Horizon AG Intercompany Note (provided
that any additional Investments in the Horizon AG Intercompany Note and the Additional Horizon AG Intercompany Note made after the Effective Date shall be subject to the provisions of the following clause (iii) or (iv)), (iii) provided no
Event of Default has occurred and is continuing, Investments by Borrowers in Horizon AG and Horizon GmbH (including Investments constituting payments payable by any Credit Party to Horizon AG and Horizon GmbH pursuant to any Permitted License)
solely to the extent required to finance the payment of operating expenses incurred by Horizon AG and Horizon GmbH in the ordinary course of business solely in connection with Horizon AG’s LODOTRA program provided that the amount of such
Investments in any month shall not exceed 115% of the LODOTRA-related expenses for such month as set forth (A) for fiscal year 2011, in the schedule of 2011 LODOTRA-related expenses set forth on Schedule 15.3 hereof, where expenses
include Cost of Goods (COGS), Quality Control/Research & Development, Sales and Marketing, and General and Administrative (G&A), and (B) for fiscal years 2012 and thereafter as set forth in Borrowers’ Annual Projections
delivered to the Administrative Agent and the Lenders pursuant to Section 6.2(f); provided, that, to the extent in any month the actual amount of LODOTRA-related expenses incurred by Horizon AG and Horizon GmbH is less than the amount specified
for such month on Schedule 15.3 or the applicable Annual Projections, the Borrowers may carry forward the unexpended budgeted amount for application in the following two (2) months and (iv) provided no Event of Default has occurred
and is continuing, a one-time Investment by Borrowers in Horizon AG after the Effective Date of up to €5,500,000 for the sole purpose of curing “over-indebtedness” of Horizon AG (within the meaning of the applicable laws of
Switzerland and International Financial Reporting Standards) provided that as conditions to the making of any such Investment, (A) the Lenders have determined in their sole discretion that curing such over-indebtedness is required by the
applicable laws of Switzerland, (B) the proceeds of such Investment are not used, directly or indirectly, to repay any Indebtedness of Horizon AG under the Existing Kreos Loan Agreement, (C) prior to the making of such Investment, Horizon
Pharma shall have closed an initial public offering of its common stock with gross cash proceeds (before deduction of underwriter commissions and expenses) to Horizon Pharma of not less than $50,000,000, and (D) the Borrowers shall have
delivered to the Administrative Agent and the Lenders a pro forma consolidated balance sheet for Horizon Pharma and its Subsidiaries showing, after giving effect to the Investment, that the consolidated cash of Horizon Pharma and its Subsidiaries
exceeds the consolidated Indebtedness of Horizon Pharma and its Subsidiaries. 

  
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 (g) Investments consisting of (x) travel advances and employee relocation loans and
other employee advances in the ordinary course of business, and (y) loans to employees, officers or directors relating to the purchase of equity securities of Horizon Pharma pursuant to employee stock purchase plans or agreements approved by
Horizon Pharma’s Board, so long as the aggregate amount of all such loans made pursuant to this clause (g) do not exceed Two Hundred and Fifty Thousand Dollars ($250,000); 

(h) Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and
in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of business; 
 (i) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers who are not Affiliates, in the ordinary course of business; provided that
this paragraph (i) shall not apply to Investments of any Credit Party in any Subsidiary; and 
 (j) joint ventures or
strategic alliances in the ordinary course of business consisting of the non-exclusive licensing of technology, the development of technology or the providing of technical support, but in no event consisting of cash investments. 

“Permitted Licenses” means (a) a non-exclusive or exclusive as to geography other than the United States license of
Intellectual Property granted to third parties (other than Horizon AG) in the ordinary course of business, (b) subject to prior satisfaction of the requirements set forth in the following sentence, an exclusive as to geography within the United
States license of Intellectual Property granted to third parties in the ordinary course of business, (c) non-exclusive licensing of technology, the development of technology or the providing of technical support, (d) non-exclusive or
exclusive manufacturing licenses, (e) intercompany licenses or other similar arrangements among the Credit Parties and (f) intercompany licenses between the Credit Parties and Horizon AG wherein Horizon AG is the licensor and one or more
Credit Parties are licensees; provided, however, that the licenses or similar arrangements described in clause (e) above shall not permit exclusive as to geography in the United States licenses of Intellectual Property and shall only permit
exclusive as to geography other than the United States licenses of Intellectual Property if a Credit Party retains all rights to such Intellectual Property other than those rights that are the subject of such license. Notwithstanding the foregoing,
any license described in clause (b) above shall not be a Permitted License hereunder unless and until (i) such Credit Party that is to be a party to such license shall have given written notice of such proposed license, which notice shall
(A) identify the parties to the proposed license, (B) include a description of the material terms and conditions of such proposed license and (C) include copies of any and all agreements relating to such proposed license, to the
Administrative Agent and to each Lender in accordance with Section 12 hereof, (ii) the Administrative Agent shall have given written acknowledgment of receipt of the foregoing notice, and (iii) the Administrative Agent shall
have given its written consent to such proposed license; provided that, in the event such requesting Credit Party does not receive a written denial thereof within ten (10) Business Days after the Administrative Agent’s acknowledgement of
receipt of such request as contemplated in clause (ii) above, then the Administrative Agent will be deemed to have given such consent, and such Credit Party shall be permitted to enter into such license arrangement, unless the material terms
and conditions of such proposed license have changed in any respect from the terms set forth in the materials provided to the Administrative Agent pursuant to clause (i) above, in which event consent shall not be deemed to have been given by
the Administrative Agent until such time as the requirements of clauses (i) through (iii) have been satisfied as to the proposed license, as so amended or modified. 
 “Permitted Liens” are: 
 (a) Liens existing on the Effective Date
and shown on the Perfection Certificate or arising under this Agreement and the other Loan Documents; 
 (b) Liens for Taxes,
fees, assessments or other government charges or levies, either (i) not due and payable or (ii) being contested in good faith and for which such Credit Party maintains adequate reserves on its Books, provided that no notice of any such
Lien has been filed or recorded under the Internal Revenue Code of 1986, as amended, and the Treasury Regulations adopted thereunder; 

  
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 (c) purchase money Liens (including capital leases) (i) on Equipment acquired or held
by a Credit Party incurred for financing the acquisition of Equipment securing no more than Five Hundred Thousand Dollars ($500,000) in the aggregate amount outstanding, or (ii) existing on Equipment when acquired, if the Lien is confined to
the property and improvements and the proceeds of the Equipment; 
 (d) Permitted Licenses; 

(e) Liens of carriers, warehousemen, suppliers, or other Persons that are possessory in nature arising in the ordinary course of business
so long as no such Lien secures liabilities in an amount in excess of One Hundred Thousand Dollars ($100,000), individually, or Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when aggregated with all such Liens, and in each
case, is not delinquent or remains payable without penalty or is being contested in good faith and by appropriate proceedings which proceedings have the effect of preventing the forfeiture or sale of the property subject thereto; 

(f) Liens to secure payment of workers’ compensation, employment insurance, old-age pensions, social security and other like
obligations incurred in the ordinary course of business (other than Liens imposed by ERISA); 
 (g) Liens arising from
attachments or judgments, orders, or decrees in circumstances not constituting an Event of Default under either Section 9.4 or 9.7; 
 (h) subject to Section 6.6, Liens in favor of other financial institutions arising in connection with deposit and/or securities accounts held at such institutions; provided that such Liens
relate solely to obligations for administrative and other banking fees and expenses incurred in the ordinary course of business in connection with the maintenance of such accounts; 

(i) statutory or common law Liens of landlords; provided that such landlords shall have waived their respective rights with respect to
such Liens pursuant to a landlord waiver agreement between such landlord and the Administrative Agent in form satisfactory to the Administrative Agent; 
 (j) Liens incurred or deposits made to secure the performance of tenders, bids, leases, statutory or regulatory obligations, surety and appeal bonds, government contracts, performance and return-of-money
bonds, and other obligations of like nature, in each case, in the ordinary course of business; provided, that at no such time shall the aggregate amount of all such Liens exceed One Hundred Thousand Dollars ($100,000); 

(k) pledges and deposits securing liability for reimbursement or indemnification obligations in respect of letters of credit or bank
guarantees for the benefit of landlords; provided, that at no such time shall the aggregate amount of all such pledges and deposits exceed One Hundred Thousand Dollars ($100,000); 

(l) a Lien on the Horizon AG Capital Stock (as defined in Exhibit A) in favor of Kreos in connection with the Existing Kreos Loan
Agreement; 
 (m) liens on (i) deposit account(s) securing Indebtedness to SVB with respect to Borrowers’ credit card
program and other cash management services provided that the amount of such Indebtedness shall at no time exceed $200,000, and (ii) in favor of SVB in respect of Borrowers’ lock-box account maintained at SVB provided that all monies in
such lock-box account are swept daily to an account at SVB subject to a Control Agreement; and 
 (n) Liens incurred in the
extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (k), but any extension, renewal or replacement Lien must be limited to the property encumbered by the existing Lien and the principal amount of the
indebtedness may not increase. 
 “Person” is any individual, sole proprietorship, partnership, limited
liability company, joint venture, company, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or government agency. 

  
 - 47 -

 “Prepayment Fee” means with respect to any Term Loan subject to prepayment
prior to the Term Loan Maturity Date, whether by mandatory or voluntary prepayment, acceleration or otherwise, an additional fee payable to the Lenders in an amount equal to: 

 

	 	(i)	for a prepayment made on or after the Funding Date of such Term Loan through and including the first anniversary of the Funding Date of such Term Loan, six percent
(6.00%) of the principal amount of such Term Loan prepaid; 

  

	 	(ii)	for a prepayment made after the first anniversary of the Funding Date of such Term Loan through and including the second anniversary of the Funding Date of such Term
Loan, three percent (3.00%) of the principal amount of such Term Loan prepaid; 

  

	 	(iii)	for a prepayment made after the second anniversary of the Funding Date of such Term Loan through and including the third anniversary of the Funding Date of such Term
Loan, two percent (2.00%) of the principal amount of such Term Loan prepaid; and 

  

	 	(iii)	for a prepayment made after the third anniversary of the Funding Date of such Term Loan but prior to the Term Loan Maturity Date, one percent (1.00%) of the
principal amount of such Term Loan prepaid. 

 “Pro Rata Share” means with respect each Lender,
the percentage obtained by dividing (a) the Term Commitment of that Lender by (b) the aggregate Term Commitments of all Lenders. 
 “Register” is defined in Section 2.8(b). 

“Registered Organization” is any “registered organization” as defined in the Code with such additions to such
term as may hereafter be made. 
 “Release” means any release, spill, emission, leaking, pumping, pouring,
injection, escaping, deposit, disposal, discharge, dispersal, dumping, leaching or migration of any Hazardous Material into the indoor or outdoor environment (including the abandonment or disposal of any barrels, containers or other closed
receptacles containing any Hazardous Material), including the movement of any Hazardous Material through the air, soil, surface water or groundwater. 
 “Required Liquidity”, as of any date of determination, shall mean the aggregate of the Credit Parties’ cash and Cash Equivalents in an amount not less than the aggregate net
reduction in the Credit Parties’ operating cash position for the immediately preceding three month period, multiplied by four (4). 
 “Requirement of Law” is as to any Person, the organizational or governing documents of such Person, and any law (statutory or common), treaty, rule or regulation or determination of an
arbitrator or a court or other Governmental Authority, in each case applicable to or binding upon such Person or any of its property or to which such Person or any of its property is subject. 

“Required Lenders” means (i) for so long as all of the Persons that are Lenders on the Effective Date (each an
“Original Lender”) have not assigned or transferred any of their interests in their respective Term Loans, Lenders holding one hundred percent (100%) of the aggregate outstanding principal balance of the Term Loans, or
(ii) at any time from and after any Original Lender has assigned or transferred any interest in its Term Loans, Lenders holding, sixty-six percent (66%) or more of the aggregate outstanding principal balance of the Term Loans, plus,
in respect of this clause (ii), (A) each Original Lender that has not assigned or transferred any portion of its respective Term Loan and (B) each assignee of an Original Lender provided such assignee was assigned or transferred and
continues to hold 100% of the assigning Original Lender’s interest in the Term Loans (in each case in respect of clauses (A) and (B) of this clause (ii), whether or not such Lender is included within the Lenders holding sixty-six
percent (66%) of the Terms Loans); provided, however, that notwithstanding the foregoing, for purposes of Section 9.1(b) hereof, “Required Lenders” means (i) for so long as all Original Lenders retain 100% of
their interests in their respective Term Loans, Lenders holding one hundred percent (100%) of the aggregate 

  
 - 48 -

 
outstanding principal balance of the Term Loans, or (ii) at any time from and after any Original Lender has assigned or transferred any interest in its Term Loans, Lenders holding, sixty-six
percent (66%) or more of the aggregate outstanding principal balance of the Term Loans, plus, in respect of this clause (ii), each Original Lender that has not assigned or transferred any portion of its respective Term Loan (in each case in
respect of this clause (ii), whether or not such Original Lender is included within the Lenders holding sixty-six percent (66%) of the Term Loans). For purposes of this definition only, a Lender shall be deemed to include itself, and any Lender
that is an Affiliate or Approved Fund of such Lender. 
 “Responsible Officer” is any of the Chief Executive
Officer, President, Chief Financial Officer and Controller of any Credit Party or, in respect of Horizon UK, the UK equivalent thereof. 
 “Restricted License” is any material license or other agreement with respect to which a Credit Party is the licensee (a) that prohibits or otherwise restricts such Credit Party from
granting a security interest in such Credit Party’s interest in such license or agreement or any other property, or (b) for which a default under or termination of which could interfere with the Administrative Agent’s right to sell
any Collateral. 
 “SEC” shall mean the Securities and Exchange Commission, any successor thereto, and any
analogous Governmental Authority. 
 “Securities” means any stock, shares, partnership interests, voting trust
certificates, certificates of interest or participation in any profit sharing agreement or arrangement, options, warrants, bonds, debentures, notes, or other evidences of indebtedness, secured or unsecured, convertible, subordinated or otherwise, or
in general any instruments commonly known as “securities” or any certificates of interest, shares or participations in temporary or interim certificates for the purchase or acquisition of, or any right to subscribe to, purchase or acquire,
any of the foregoing. 
 “Securities Account” is any “securities account” as defined in the Code with
such additions to such term as may hereafter be made. 
 “Securities Act” means the Securities Act of 1933, as
amended from time to time, and any successor statute. 
 “Security Trust Deed” means the security trust deed
dated on or about the Effective Date and entered into between Horizon UK, Oxford (as original Lender), Silicon Valley Bank (as original Lender), the Administrative Agent and Oxford (as security trustee for the Lenders), as amended and/or restated,
varied or supplemented from time to time. 
 “Solvent” means, with respect to any Person on any date of
determination, that on such date (a) the fair value of the property of such Person is greater than the total amount of liabilities, including contingent liabilities, of such Person, (b) the present fair salable value of the assets of such
Person is not less than the amount that will be required to pay the probable liability of such Person on its debts as they become absolute and matured, (c) such Person will not be left with unreasonably small capital, and (d) such Person
is able to both service and pay its liabilities as they mature. In computing the amount of contingent or unliquidated liabilities at any time, such liabilities will be computed as the amount that, in light of all the facts and circumstances existing
at such time, represents the amount that is likely to become an actual or matured liability. 
 “Subordinated
Debt” is (i) indebtedness incurred by Horizon Pharma pursuant to Horizon Pharma’s subordinated convertible promissory notes comprising the second tranche of the financing contemplated by the terms of that certain Series B
Preferred Stock and Subordinated Convertible Note Purchase Agreement, dated as of April 1, 2010, as the same may be amended from time to time, and (ii) indebtedness incurred by any Credit Party subordinated to all of such Credit
Party’s now or hereafter incurred indebtedness to the Lenders (pursuant to a subordination, intercreditor, or other similar agreement in form and substance satisfactory to the Administrative Agent entered into between the Administrative Agent
and the other creditor), on terms acceptable to the Administrative Agent. 
 “Subsidiary” is, as to any Person,
(a) a subsidiary as defined in section 1159 of the UK Companies Act 2006; (b) unless the context otherwise requires, a subsidiary undertaking within the meaning of section 1162 of the UK Companies Act 2006; or (c) a corporation,
partnership, limited liability company or other entity of which shares of stock or other ownership interests having ordinary voting power (other than stock or such other ownership 

  
 - 49 -

 
interests having such power only by reason of the happening of a contingency) to elect a majority of the board of directors or other managers of such corporation, partnership or other entity are
at the time owned, or the management of which is otherwise controlled, directly or indirectly through one or more intermediaries, or both, by such Person. Unless the context otherwise requires, each reference to a Subsidiary herein shall be a
reference to a Subsidiary of a Credit Party. 
 “Supplemental Debenture” means the supplemental debenture
granted by Horizon UK in favor of the Administrative Agent (as security trustee for the Lenders). 
 “SVB”
means Silicon Valley Bank. 
 “Tax” means any present or future tax, levy, impost, duty, assessment, charge,
fee, deduction or withholding of any nature and whatever called, by whomsoever, on whomsoever and wherever imposed, levied, collected, withheld or assessed, including any tax of any kind whatsoever (whether disputed or not) imposed by any
Governmental Authority with respect to any Credit Party or any of its Subsidiaries or with respect to any member of a consolidated, affiliated, combined or unitary group in which any Credit Party or any of its Subsidiaries is or has been a member,
including any related charges, fees, interest, penalties, additions to tax or other assessments (including as a result of any obligation arising out of an agreement to indemnify any other Person); provided, “Tax on the overall net income”
of a Person shall be construed as a reference to a tax imposed by the jurisdiction in which that Person is organized or in which that Person’s applicable principal office (and/or, in the case of a Lender, its lending office) is located or in
which that Person (and/or, in the case of a Lender, its lending office) is deemed to be doing business on all or part of the net income, profits or gains (whether worldwide, or only insofar as such income, profits or gains are considered to arise in
or to relate to a particular jurisdiction, or otherwise) of that Person (and/or, in the case of a Lender, its applicable lending office). 
 “Term Commitment” means the commitment of a Lender to make or otherwise fund any Term Loan and “Term Commitments” means such commitments of all Lenders in the aggregate. The
amount of each Lender’s Term Commitment, if any, is set forth on Schedule 1.1, subject to any adjustment or reduction pursuant to the terms and conditions hereof. The aggregate amount of the Term Commitments as of the Effective Date is
$17,000,000. 
 “Term Loan” is defined in Section 2.2. 

“Term Loan Maturity Date” is, for each Term Loan, the date which is forty-eight (48) months after the first Payment
Date with respect to such Term Loan. 
 “Term Loan Note” means a promissory note in form reasonably acceptable
to the Administrative Agent and the Lenders, as it may be amended, restated, supplemented or otherwise modified from time to time. 
 “Trademarks” means any trademark and servicemark rights, whether registered or not, applications to register and registrations of the same and like protections, and the entire goodwill of
the business of the Credit Party connected with and symbolized by such trademarks. 
 “Transfer” is defined in
Section 7.1. 
 “Warrants” are those certain Warrants to Purchase Series B Preferred Stock, dated
as of the Effective Date, executed by Horizon Pharma in favor of Oxford and SVB. 
 “United Kingdom” or
“UK” means the United Kingdom of Great Britain and Northern Ireland. 
 “UK Insolvency
Proceeding” means in relation to any Person: (a) any step is taken with a view to a moratorium or a composition, assignment or similar arrangement with any of its creditors; (b) a meeting of its shareholders, directors or other
officers is convened for the purpose of considering any resolution for, to petition for or to make an application to or to file documents with a court or any registrar for, its winding-up, administration or dissolution or any such resolution is
passed; (c) an order is made for its winding-up, administration or dissolution, or any Person presents a petition, or makes an application to or files documents with a court or any registrar, for its winding-up, administration or dissolution,
or gives notice to the Administrative Agent of an intention to appoint an administrator other than, in any case, any winding up petition which is frivolous or vexatious and is discharged, 

  
 - 50 -

 
stayed, or dismissed within fourteen (14) days of commencement or, if earlier, the date on which it is advertised (but no Credit Extensions shall be made until such petition is dismissed);
(d) any liquidator, receiver, administrative receiver, administrator or similar officer is appointed in respect of it or any of its assets; or (e) its shareholders, directors or other officers request the appointment of, or give notice of
their intention to appoint, a liquidator, receiver, administrator or similar officer. 
 “U.S. Lender” is
defined in Section 2.6(c). 
 [Signature page follows.] 

  
 - 51 -

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as
of the Effective Date. 
  

			
	 HORIZON PHARMA USA, INC.,
 as Borrower

			
		
	By	 	 /s/ Robert De Vaere

			
	Name:	 	 Robert J. De Vaere

			
	Title:	 	
Executive Vice President and Chief Financial Officer

	
	 HORIZON PHARMA, INC.,
 as Borrower

			
		
	By	 	 /s/ Robert De Vaere

			
	Name:	 	 Robert J. De Vaere

			
	Title:	 	
Executive Vice President and Chief Financial Officer

	
	 HORIZON PHARMA (UK) LIMITED,
 as Borrower

			
		
	By	 	 /s/ Robert De Vaere

			
	Name:	 	 Robert J. De Vaere

			
	Title:	 	Director

 Signature Page to
Loan and Credit Agreement - Horizon 

			
	 OXFORD FINANCE LLC,
 as a Lender

			
		
	By	 	 /s/ Timothy A. Lex

			
	Name:	 	 Timothy A. Lex

			
	Title:	 	 COO

 Signature Page to Loan and Credit Agreement - Horizon 

			
	 SILICON VALLEY BANK,
 as a Lender

			
		
	By	 	 /s/ Kristen Parsons

			
	Name:	 	 Kristen Parsons

			
	Title:	 	 Deal Team Leader

Signature Page to Loan and Credit Agreement - Horizon 

			
	 OXFORD FINANCE LLC,
 as Administrative Agent

			
		
	By	 	 /s/ Timothy A. Lex

			
	Name:	 	 Timothy A. Lex

			
	Title:	 	 COO

 Signature Page to Loan and Credit Agreement - Horizon 

 SCHEDULE 1.1 

LENDERS AND COMMITMENTS 
 Term Loans 
  

					
	 Lender
	  	 Term Commitment
	  	 Commitment Percentage

	 Oxford Finance LLC
	  	$12,000,000	  	70.589%
	 Silicon Valley Bank
	  	$5,000,000	  	29.411%
	 TOTAL
	  	$17,000,000	  	100.00%

  
 A - 1

 EXHIBIT A – COLLATERAL DESCRIPTION 

The Collateral consists of all of each Credit Party’s right, title and interest in and to the following personal property:

 All goods, Accounts (including health-care receivables), Equipment, Inventory, contract rights or rights to payment of money,
leases, license agreements, franchise agreements, General Intangibles (except “intent-to-use” trademarks as provided below), commercial tort claims, documents, instruments (including any promissory notes), chattel paper (whether tangible
or electronic), cash, deposit accounts, fixtures, letters of credit rights (whether or not the letter of credit is evidenced by a writing), securities, and all other investment property, supporting obligations, and financial assets, whether now
owned or hereafter acquired, wherever located; and 
 All Books relating to the foregoing, and any and all claims, rights and
interests in any of the above and all substitutions for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of any or all of the foregoing. 

Notwithstanding the foregoing, the Collateral shall not include (i) any “intent-to-use” trademarks at all times prior to
the first use thereof, whether by the actual use thereof in commerce, the recording of a statement of use with the United States Patent and Trademark Office or otherwise or (ii) the shares of capital stock of Horizon AG held by Horizon Pharma,
together with (x) all dividend payments relating to such shares whether in cash or in the form of additional shares or in any other form and (y) all monies payable in respect of such shares, including, without limitation, repayments of the
nominal value of such shares and all other rights, benefits, and proceeds in respect of or derived from such shares (whether by way of redemption, subscription rights, bonus shares, preference, option, substitution, conversion or otherwise)
(collectively, the “Horizon AG Capital Stock”); provided that upon the payment in full of the obligations of Horizon AG to Kreos in respect of the Existing Loan Agreement, the Collateral shall include the Horizon AG Capital Stock
representing 65% of the total combined voting power of all classes of stock entitled to vote the shares of capital stock of Horizon AG. 

  
 - 2 -

 EXHIBIT B – LOAN PAYMENT/ADVANCE REQUEST FORM 

DISBURSEMENT LETTER 
 The
undersigned, being the duly elected and acting                              of HORIZON PHARMA
USA, INC., a Delaware corporation (formerly called HORIZON THERAPEUTICS, INC.) (“Horizon”), HORIZON PHARMA, INC., a Delaware corporation (“Horizon Pharma,”), HORIZON PHARMA (UK) LIMITED, a company registered under
the laws of England and Wales, with registration number 05819120, with its registered offices in the United Kingdom at c/o Arnold & Porter (UK) LLP, Tower 42, 24 Old Broad Street, London EC2N 1HQ (“Horizon UK”, and together
with Horizon and Horizon Pharma, each a “Borrower” and, collectively, jointly and severally, the “Borrowers”) with offices located at 1033 Skokie Boulevard, Suite 355, Northbrook, IL 60062, does hereby certify to
OXFORD FINANCE LLC, (“Oxford”, as administrative agent (the “Administrative Agent”) and the Lenders (as defined below) in connection with that certain Loan and Security Agreement dated on or about the date
hereof by and among Administrative Agent , Borrowers, and the lenders (the “Lenders”) party thereto, including Oxford and Silicon Valley Bank (the “Loan Agreement”; with other capitalized terms used below having the
meanings ascribed thereto in the Loan Agreement) that: 
 1. The representations and warranties made by Borrowers in
Section 5 of the Loan Agreement and in the other Loan Documents are true and correct in all material respects as of the date hereof. 
 2. No event or condition has occurred that would constitute an Event of Default under the Loan Agreement or any other Loan Document. 

3. Borrowers are in compliance with the covenants and requirements contained in Sections 4, 6 and 7 of the Loan Agreement.

 4. All conditions referred to in Section 3 of the Loan Agreement to the making of the Term Loans to be made on or
about the date hereof have been satisfied or waived by Administrative Agent. 
 5. No Material Adverse Change has occurred.

 6. The undersigned is a Responsible Officer. 
 7. The proceeds for the Term Loan shall be disbursed as follows: 
  

							
	 Disbursement from Oxford:
	  				  	
	 Loan Amount
	  	$	                    	  	  	
	 Less:
	  				  	
	 Facility Fee
	  	$	                    	  	  	
	 Lender Expenses
	  	$	                    	  	  	
			
	 Net proceeds due from Oxford:
	  	$	                    	  	  	
			
	 Disbursement from Silicon Valley Bank:
	  				  	
	 Loan Amount
	  	$	                    	  	  	
	 Less:
	  				  	
	 Facility Fee
	  	$	                    	  	  	
	 Lender Expenses
	  	$	                    	  	  	
			
	 Net proceeds due from Silicon Valley Bank
	  	$	                    	  	  	

 The aggregate net proceeds of the Term Loan in the amount of
$                     shall be transferred to Borrowers’ account as follows: 

 

							
	Account Name:	 	  
	 		 	
	 Bank Name:
	 	  
	 		 	

  
 C - 1

							
	Bank Address:	 	  
	 		 	
	Account Number:	 	  
	 		 	
				
	ABA Number:	 	  
	 		 	

 Dated:
                                 

[signature pages follow] 

  
 - 2 -

			
	 HORIZON PHARMA USA, INC.,
 as Borrower

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

	
	 HORIZON PHARMA, INC.,
 as Borrower

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

	
	 HORIZON PHARMA (UK) LIMITED,
 as Borrower

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	Director
	
	 OXFORD FINANCE LLC,
 as a Lender

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

	
	 SILICON VALLEY BANK,
 as a Lender

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

	
	 OXFORD FINANCE LLC,
 as Administrative Agent

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

  
 - 3 -

 EXHIBIT C -COMPLIANCE CERTIFICATE 

 

			
	 	  	OXFORD FINANCE LLC, AS
	TO:	  	ADMINISTRATIVE AGENT
	FROM:	  	 HORIZON PHARMA USA, INC.,

HORIZON PHARMA, INC. and HORIZON PHARMA (UK) LIMITED

 The undersigned authorized officer of HORIZON PHARMA USA, INC., a Delaware corporation (formerly called HORIZON THERAPEUTICS, INC.) (“Horizon”), HORIZON PHARMA, INC., a Delaware
corporation (“Horizon Pharma,”), HORIZON PHARMA (UK) LIMITED, a company registered under the laws of England and Wales, with registration number 05819120, with its registered offices in the United Kingdom at c/o Arnold &
Porter (UK) LLP, Tower 42, 24 Old Broad Street, London EC2N 1HQ (“Horizon UK”, and together with Horizon and Horizon Pharma, each a “Borrower” and, collectively, jointly and severally, the
“Borrowers”) hereby certifies that in accordance with the terms and conditions of the Loan and Security Agreement dated June 2, 2011 by and among Administrative Agent , Borrowers, and the lenders party thereto (the
“Lenders”), including Oxford and Silicon Valley Bank (the “Loan Agreement”): 
 (i) Borrowers are in
complete compliance for the period ending                      with all required covenants except as noted below; 

(ii) There are no Events of Default, except as noted below; 
 (iii) Except as noted below, all representations and warranties of Borrowers stated in the Loan Documents are true and correct in all material respects on this date except as noted below; provided,
however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties
expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date; 
 (iv) Borrowers, and
each of their respective Subsidiaries, have timely filed all required tax returns and reports or extensions therefor, and Borrowers, and each of their respective Subsidiaries, have timely paid all foreign, federal, state, and local taxes,
assessments, deposits and contributions owed by Borrowers and each of their respective Subsidiaries, except as otherwise permitted pursuant to the terms of Section 5.9 of the Loan Agreement; 

(v) No Liens have been levied or claims made against Borrowers or any of their respective Included Subsidiaries relating to unpaid employee payroll or
benefits of which Borrowers have not previously provided written notification to Administrative Agent; 
 (vi) With respect to Borrower’s
leased location at 533 Bryant Street, Suite 6, Palo Alto, California 94301 and each other leased location for which Borrower has been unable to obtain a landlord’s consent in favor of Lender in accordance with Section 3.1.(i)
hereof, no default or event of default exists under any lease applicable to such location(s); 
 Attached are the required documents, if
any, supporting our certification(s). The undersigned officer on behalf of Borrowers further certifies that the attached financial statements are prepared in accordance with Applicable Accounting Standards and are consistently applied from one
period to the next except as explained in an accompanying letter or footnotes and except, in the case of unaudited financial statements, for the absence of footnotes and subject to year-end audit adjustments as to the interim financial statements.
Capitalized terms used but not otherwise defined herein shall have the meanings given them in the Loan Agreement. 

  
 - 4 -

 Please indicate compliance status since the last Compliance Certificate by circling Yes, No, or N/A under
“Complies” column. 
  

																					
	 	  	 Reporting Covenant
	  	 Requirement
	  	 	 	  	Complies	 
							
	 1)
	  	Financial statements	  	Monthly within 30 days	  				  	 	Yes	  	  	 	No	  	  	 	N/A	  
							
	 2)
	  	Annual (CPA Audited) statements	  	Within 180 days after Fiscal Year End	  				  	 	Yes	  	  	 	No	  	  	 	N/A	  
							
	 3)
	  	Annual Financial Projections/Budget (prepared on a monthly basis)	  	Annually (w/n 10/90 days of FYE) and when revised	  				  	 	Yes	  	  	 	No	  	  	 	N/A	  
							
	 4)
	  	A/R & A/P agings	  	If applicable	  				  	 	Yes	  	  	 	No	  	  	 	N/A	  
							
	 5)
	  	8-K, 10-K and 10-Q Filings	  	If applicable	  				  	 	Yes	  	  	 	No	  	  	 	N/A	  
							
	 6)
	  	IP Report	  	when required	  				  	 	Yes	  	  	 	No	  	  	 	N/A	  
							
	 7)
	  	Total amount of Borrowers’ cash and cash equivalents at the last day of the measurement period	  		  	 	$            	  	  				  				  			
	 8)
	  		  	Month	  	 	QTD	  	  	 	YTD	  	  				  			
							
		  		  		  	 	$                    	  	  				  				  			
							
	 9)
	  		  		  				  				  				  			
			
		  	Deposit and Securities Accounts	  	(Please list all accounts; attach separate sheet if additional space needed)	  
					
	  	  	 Bank
	  	 Account Number
	  	New Account?	 	  	Acct Control
Agmt in
place?	 
							
	 1)
	  	Silicon Valley Bank	  		  	 	Yes	  	  	 	No	  	  	 	Yes	  	  	 	No	  
							
	 2)
	  	Silicon Valley Bank	  		  	 	Yes	  	  	 	No	  	  	 	Yes	  	  	 	No	  
							
	 3)
	  	Silicon Valley Bank	  		  	 	Yes	  	  	 	No	  	  	 	Yes	  	  	 	No	  
							
	 4)
	  		  		  	 	Yes	  	  	 	No	  	  	 	Yes	  	  	 	No	  
							
	 5)
	  		  		  	 	Yes	  	  	 	No	  	  	 	Yes	  	  	 	No	  
							
	 6)
	  		  		  	 	Yes	  	  	 	No	  	  	 	Yes	  	  	 	No	  
							
		  	Financial Covenants 	  	Requirement	  	 	Actual	  	  				  	 	Compliance	  	  			
							
		  	Other Matters	  		  				  				  				  			
						
		  	Have there been any changes in management since the last Compliance Certificate?	  				  	 	Yes	  	  	 	No	  	  			

  
 - 5 -

															
		  	Have there been any transfers/sales/disposals/retirement of Collateral or IP prohibited by the Agreement?	 	Yes	  	No	 		 	
						
		  	Have there been any new or pending claims or causes of action against Borrower that involve more than $100,000?	 	Yes	  	No	 		 	
							
		  	Exceptions	 		 		  		 		 	
			
		  	Please explain any exceptions with respect to the certification above: (If no exceptions exist, state “No exceptions.” Attach separate sheet if additional
space needed.)	 	  

		  	 	  

		  	 	  

		  	 	  

															
					
		 		 	  
	  		  	 LENDERS USE
 ONLY

		 	HORIZON PHARMA USA, INC., HORIZON PHARMA, INC. and HORIZON PHARMA (UK) LIMITED	 	  DATE	  		  	
		 	By:                             
     	 		  		  	Received by:	 	             	 	Verified by:	 	             
								
		 	Name:                            
	 		  		  		 		 		 	
								
		 	Title:                            
  	 		  		  	Date:	 	                     	 	Date:	 	                     
							
		 		 		  		  	Compliance Status	 	Yes	 	No

  
 - 6 -

 EXHIBIT D 

SECURED PROMISSORY NOTE 
  

			
	$                    	 	Dated:                     
    , 2011

 FOR VALUE RECEIVED, the undersigned, HORIZON PHARMA USA, INC., a Delaware
corporation (formerly called HORIZON THERAPEUTICS, INC.) (“Horizon”), HORIZON PHARMA, INC., a Delaware corporation (“Horizon Pharma,”), HORIZON PHARMA (UK) LIMITED, a company registered under the laws of England and
Wales, with registration number 05819120, with its registered offices in the United Kingdom at c/o Arnold & Porter (UK) LLP, Tower 42, 24 Old Broad Street, London EC2N 1HQ (“Horizon UK”, and together with Horizon and
Horizon Pharma, each a “Borrower” and, collectively, jointly and severally, the “Borrowers”), jointly and severally, HEREBY PROMISE TO PAY to the order of OXFORD FINANCE LLC/SILICON VALLEY BANK
(“Lender”) the principal amount of [                    ] MILLION DOLLARS
[($                    )] or such lesser amount as shall equal the outstanding principal balance of the Term Loan made to Borrowers by Lender,
plus interest on the aggregate unpaid principal amount of Term Loan, at the rates and in accordance with the terms of the Loan and Security Agreement dated June 2, 2011 by and among Borrowers, Oxford Finance LLC, as Administrative Agent and as
a Lender, and the other Lenders from time to time party thereto (as amended, restated, supplemented or otherwise modified from time to time, the “Loan Agreement”). If not sooner paid, the entire principal amount and all accrued and
unpaid interest hereunder shall be due and payable on the Term Loan Maturity Date as set forth in the Loan Agreement. Any capitalized term not otherwise defined herein shall have the meaning attributed to such term in the Loan Agreement. 

Borrowers agree to pay any initial partial monthly interest payment from the date the Term Loan is made to Borrowers under this Secured Promissory Note
(this “Note”) to the first Payment Date (“Interim Interest”) on the first Payment Date. 
 Principal, interest
and all other amounts due with respect to the Term Loan, are payable in lawful money of the United States of America to Lender as set forth in the Loan Agreement and this Note. The principal amount of this Note and the interest rate applicable
thereto, and all payments made with respect thereto, shall be recorded by Lender and, prior to any transfer hereof, endorsed on the grid attached hereto which is part of this Note. 
 The Loan Agreement, among other things, (a) provides for the making of a secured Term Loan by Lender to Borrowers, and (b) contains provisions for acceleration of the maturity hereof upon the
happening of certain stated events. 
 This Note may not be prepaid except as set forth in Section 2.2 (c) and Section 2.2(d) of
the Loan Agreement. 
 This Note and the obligation of Borrowers to repay the unpaid principal amount of the Term Loan, interest on the Term
Loan and all other amounts due Lender under the Loan Agreement is secured under the Loan Agreement. 
 Presentment for payment, demand, notice
of protest and all other demands and notices of any kind in connection with the execution, delivery, performance and enforcement of this Note are hereby waived. 
 Borrowers shall pay all reasonable fees and expenses, including, without limitation, reasonable attorneys’ fees and costs, incurred by Lender in the enforcement or attempt to enforce any of
Borrowers’ obligations hereunder not performed when due. 
 This Note shall be governed by, and construed and interpreted in accordance
with, the internal laws of the State of California. 

  
 - 7 -

 Note Register; Ownership of Note. The ownership of an interest in this Note shall be registered on a
record of ownership maintained by Lender or its agent. Notwithstanding anything else in this Note to the contrary, the right to the principal of, and stated interest on, this Note may be transferred only if the transfer is registered on such record
of ownership and the transferee is identified as the owner of an interest in the obligation. Borrowers shall be entitled to treat the registered holder of this Note (as recorded on such record of ownership) as the owner in fact thereof for all
purposes and shall not be bound to recognize any equitable or other claim to or interest in this Note on the part of any other person or entity. 

  
 - 8 -

 IN WITNESS WHEREOF, Borrowers have caused this Note to be duly executed by one of its
officers thereunto duly authorized on the date hereof. 
  

			
	BORROWERS:
	
	 HORIZON PHARMA USA, INC.,
 as Borrower

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

	
	 HORIZON PHARMA, INC.
 as Borrower

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

	
	 HORIZON PHARMA (UK) LIMITED,
 as Borrower

			
		
	By	 	  

			
	Name:	 	  

			
	Title:	 	  

  
 - 9 -

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