Document:

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                                                                   Exhibit 10.17
                       AMENDED AND RESTATED CROSS LICENSE
                                      AND
                         SOFTWARE MAINTENANCE AGREEMENT

     THIS AMENDED AND RESTATED CROSS LICENSE AND SOFTWARE MAINTENANCE AGREEMENT
(this "Agreement") is made and entered into as of the January 8, 2001, by and
between IDX SYSTEMS CORPORATION, a Vermont corporation, with offices at 1400
Shelburne Road, South Burlington, Vermont 05403 ("IDX"), and CHANNELHEALTH,
INCORPORATED, a Delaware corporation, with offices at 25 Green Mountain Drive,
South Burlington, Vermont 05403 ("ChannelHealth").

                                   Background

     IDX and ChannelHealth entered into that certain Cross License and Software
Maintenance Agreement dated January 1, 2000.

     ChannelHealth is in the business of, among other things, developing and
marketing products and services known as the "Physician Channel" to automate the
delivery of office-based clinical care, the "Patient Channel" to automate
communication between physicians and their patients, and the "eCommerce Channel"
to automate aspects of claims and payments for healthcare.

     IDX is interested in retaining the eCommerce Channel business and certain
components of the Patient Channel business and in divesting the Physician
Channel business.  Allscripts Healthcare Solutions, Inc., a Delaware corporation
("Allscripts"), is interested in acquiring the Physician Channel business of
ChannelHealth.

     As of July 13, 2000, (i) IDX and ChannelHealth entered into an Asset
Purchase Agreement whereby, on the date hereof, IDX shall acquire the assets and
assume the liabilities associated with the eCommerce Channel business and
certain components of the Patient Channel business and (ii) IDX and Allscripts
entered into an Agreement and Plan of Merger (the "Merger Agreement") whereby
ChannelHealth, on the date hereof, will become a subsidiary of Allscripts, and
concurrently herewith, IDX and Allscripts have entered into a Strategic Alliance
Agreement whereby they shall cooperatively develop and market integrated office
practice management and clinical management systems.

     IDX and ChannelHealth desire to restate and supersede the Cross License and
Software Maintenance Agreement, dated as of January 1, 2000, entered into by and
between IDX and ChannelHealth (the "License Agreement"), to reflect (i) the
conveyance by ChannelHealth of the eCommerce Channel business and certain
components of the Patient Channel, and (ii) the conveyance of certain
intellectual properties related to the Physician Channel by IDX to
ChannelHealth.
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     IN CONSIDERATION of the premises, the mutual covenants and agreements
hereinafter set forth, and other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree as follows:

1.   SCOPE AND EFFECT

     From and after the Effective Time, each party shall be relieved from all
obligations to perform the License Agreement that shall have arisen from and
after the Effective Time, but this Agreement shall not relieve any party to the
License Agreement from any obligation that shall have arisen prior to the
Effective Time.  Except for any such obligations, this Agreement shall supersede
the License Agreement.

2.   DEFINITIONS

     The capitalized terms used in this Agreement and not otherwise defined in
this Agreement shall have the meanings ascribed to them on Schedule 1 attached
hereto.

3.   IDX LICENSE GRANTS AND CONVEYANCE OF INTELLECTUAL PROPERTY

     As of the Effective Time, IDX grants licenses to ChannelHealth and makes
conveyances of intellectual property to ChannelHealth as set forth in this
Section 3, all of which shall for the purposes of this Agreement be deemed
effective as of the Closing Date.

3.1  In General.  IDX hereby grants to ChannelHealth a perpetual (except as set
     forth in Section 3.2), non-exclusive, non-cancellable and non-teminable,
     fully paid-up license (i) to copy, use, display, perform, adapt, modify,
     create derivative works of, and maintain the IDX Software, in whole or in
     part, solely for the purpose of Merging the IDX Software into Allscripts
     Products, (ii) to market and sublicense (including through one or more
     Distribution Partners), and in connection therewith to copy, use,
     distribute, perform, and display the IDX Software, in whole or in part,
     only as the IDX Software may be Merged into Allscripts Products, and (iii)
     to use and practice the IDX Licensed Technology to accomplish the purposes
     set forth in clauses (i) and (ii) of this Section 3.1.

3.2  Subject to Section 3.4.3, IDX shall make no claim to any derivative works
     developed by or on behalf of ChannelHealth pursuant to Section 3.1.

3.3  New Enabling Technologies. Upon the Termination and/or nonrenewal of the
     Strategic Alliance Agreement, the licenses granted to ChannelHealth shall
     terminate with respect to all New Enabling Technologies, except for New
     Enabling Technologies embodied in the Web FrameWork and ConnectR.  From and
     after such termination, ChannelHealth shall not use any New Enabling
     Technologies for any purpose other than to create or maintain compatibility
     or connectivity between Allscripts Products and IDX Products.

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3.4  Ownership, Patent Prosecution and Enforcement.

     3.4.1  IDX hereby transfers and assigns to ChannelHealth all of its
            copyrights in and to the products known as CMS and the Physician
            Channel. IDX shall execute an assignment in the form attached hereto
            as Exhibit 3.4.1 to effectuate and confirm such assignment.

     3.4.2  Except for the rights expressly granted herein to ChannelHealth, IDX
            reserves and retains all right, title and interest (including
            without limitation patents and copyrights) in, the IDX Licensed
            Technology, the Virtual Office, Health Resources, the eCommerce
            Channel, DietSite, and all customizations, additions, modifications,
            changes, enhancements, improvements, and derivative works thereof
            made by IDX or on behalf of IDX, and all rights therein and copies
            thereof.

     3.4.3  IDX reserves and retains all right, title and interest to any and
            all patentable inventions made, conceived, or reduced to practice by
            IDX, including without limitation by IDX personnel, employees or
            contractors, whether in whole or in part, both before and after the
            Reference Date. ChannelHealth agrees to cooperate in every
            reasonable way with IDX, at IDX's cost, to prosecute patent
            applications for such inventions and to perfect IDX's right, title
            and interest in and to such inventions and patent applications. The
            parties agree and acknowledge that certain ChannelHealth personnel
            were IDX employees, or were otherwise associated with IDX, before
            the Reference Date, and ChannelHealth agrees to cooperate in every
            reasonable way with IDX to prosecute patent applications for such
            inventions and to perfect IDX's right, title and interest in and to
            such inventions and patent applications.

     3.4.4  ChannelHealth reserves and retains all right, title and interest to
            any and all patentable inventions with claims in part or wholly
            directed to inventions embodied in, or necessary to implement and
            practice the Physician Channel alone, or in combination with any
            other product or service made, conceived, or reduced to practice by
            ChannelHealth, including without limitation by ChannelHealth
            personnel, employees or contractors.

     3.4.5  In the event IDX does not wish to prosecute a patent application for
            an invention owned by IDX, and directed to, embodied in, or
            necessary to implement and practice the Physician Channel,
            ChannelHealth may elect to prosecute that application at its
            expense.

     3.4.6  If IDX decides not to enforce any issued patent with claims in part
            or wholly directed to inventions embodied in, or necessary to
            implement and practice the Physician Channel alone, or in
            combination with any other product or service, ChannelHealth may at
            its sole expense request that either IDX, at its sole discretion,
            either bring an action for infringement against the alleged
            infringing party or parties, or assign sufficient rights in the
            patent to ChannelHealth to enable ChannelHealth to have standing to
            enforce the patent on its own.

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3.5  Limitations, Restrictions, and Conditions.  The licenses granted to
     ChannelHealth hereunder are subject to the following limitations,
     restrictions, and conditions:

     3.5.1  Distribution Pursuant to Strategic Alliance Agreement. During the
            Initial Term of the Strategic Alliance Agreement, ChannelHealth's
            use of the IDX Licensed Technology or any part thereof, including as
            Merged into Allscripts Products, is governed by the Strategic
            Alliance Agreement. This restriction shall not apply following the
            Initial Term or the termination of the Strategic Alliance Agreement.

     3.5.2  ChannelHealth shall have the right to use internally IDX Database
            Information only in connection with the Integration Methods, so long
            as such use does not induce disclosure of IDX Database Information
            to any Person not a party to this Agreement. At no time shall
            ChannelHealth license or authorize any Person to use any Integration
            Method or to use any IDX Database Information to exchange data
            between any IDX products and any products of any Person not a party
            to this Agreement. The foregoing shall not prohibit or restrict
            ChannelHealth from (i) providing any Allscripts Products to any
            ChannelHealth Customer using any Integration Method to provide
            installation services with respect to such ChannelHealth Customer or
            using IDX Database Information, in each case solely for the benefit
            of such Customer in using Allscripts Products, or (ii) using
            contractors as set forth in Section 3.5.4.

     3.5.3  ChannelHealth may permit third parties to provide to ChannelHealth
            or ChannelHealth Customers maintenance, disaster recovery,
            facilities management, outsourcing or other services involving
            access to the IDX Licensed Technology only if such third parties in
            each instance shall execute written nondisclosure and non-use
            agreements with ChannelHealth, in form and substance reasonably
            satisfactory to IDX and ChannelHealth, prior to using or gaining
            access to the IDX Licensed Technology.

     3.5.4. ChannelHealth may adapt, modify, merge, and maintain the IDX
            Licensed Technology as permitted under this Agreement through its
            own employees or through independent contractors, provided each such
            independent contractor shall in each instance execute a written
            nondisclosure and non-use agreement with ChannelHealth, in form and
            substance reasonably satisfactory to IDX and ChannelHealth, prior to
            gaining access to the Source Code.

     3.5.5  ChannelHealth may not indicate that any portion of the IDX Licensed
            Technology originated from IDX, except with IDX's prior written
            consent and except as may be otherwise expressly set forth in the
            Strategic Alliance Agreement.

3.6  Certain Terms of Third Party Agreements for IDX Licensed Technology.
     ChannelHealth shall not allow the use of or access to the IDX Licensed
     Technology by any third party (including a Distribution Partner) unless
     such party has signed and delivered to ChannelHealth an agreement
     restricting use of such

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     IDX Licensed Technology in a manner consistent with this Agreement, and
     ChannelHealth shall use reasonable efforts to include language
     substantially similar to the following in any such third party agreements:

       IN NO EVENT SHALL CHANNELHEALTH'S SUPPLIERS AND LICENSORS BE LIABLE FOR
       ANY DAMAGES OF ANY KIND OR NATURE, INCLUDING DIRECT, INDIRECT,
       INCIDENTAL, SPECIAL, PUNITIVE, EXEMPLARY OR CONSEQUENTIAL, ARISING OUT OF
       THE USE OF ANY SOFTWARE SUPPLIED BY CHANNELHEALTH, ITS SUPPLIERS OR
       LICENSORS. THE LICENSEE UNDERSTANDS AND AGREES THAT THE SOFTWARE PROVIDED
       BY CHANNELHEALTH TO LICENSEE CONTAINS SOFTWARE THAT IS THE COPYRIGHTED
       PRODUCT AND A TRADE SECRET OF CHANNELHEALTH OR ITS SUPPLIERS AND
       LICENSORS, AND THAT LICENSEE WILL NOT USE ANY SUCH SOFTWARE IN VIOLATION
       OF THE RESTRICTIONS CONTAINED IN THIS AGREEMENT AND WILL NOT DISCLOSE THE
       SOFTWARE TO ANYONE OTHER THAN ITS EMPLOYEES OR AGENTS AS REASONABLY
       NECESSARY FOR THE PURPOSE OF THIS AGREEMENT AND ON THE CONDITION THAT IT
       ACCEPTS FULL RESPONSIBILITY FOR ANY BREACH HEREOF BY ANY SUCH INDIVIDUAL.
       THE FOREGOING AGREEMENTS ARE FOR THE EXPRESS BENEFIT OF CHANNELHEALTH,
       ITS SUPPLIERS AND LICENSORS, AND MAY BE ENFORCED BY CHANNELHEALTH AND ITS
       SUPPLIERS AND LICENSORS.

3.7  Delivery.  As of the Reference Date, IDX has delivered one copy (in both
     object code and Source Code forms) of each component of the IDX Licensed
     Technology.

3.8  IDX Names and Marks. ChannelHealth may not use any IDX Names or Marks in
     connection with ChannelHealth's business or otherwise, except as may be
     expressly set forth in the Strategic Alliance Agreement.

3.9  Bankruptcy. All rights and licenses granted under or pursuant to this
     Agreement by IDX to ChannelHealth are, and shall otherwise be deemed to be,
     for purposes of Section 365(n) of the United States Bankruptcy Code (the
     "Code"), licenses to rights to "intellectual property" as defined in the
     Code. The parties agree that ChannelHealth, as licensee of such rights
     under this Agreement, shall retain and may fully exercise all of its rights
     and elections under the Code. The parties further agree that, in the event
     of the commencement of bankruptcy proceeding by or against IDX under the
     Code, ChannelHealth shall be entitled to retain all of its rights under
     this Agreement.

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4.   LIMITED WARRANTIES OF IDX

     Except for the warranties made in the Merger Agreement, there are NO
WARRANTIES made by IDX in connection with the subject matter of this Agreement.
The warranties of IDX set forth below are made only to ChannelHealth and shall
be true as of the Reference Date.  ChannelHealth acknowledges that, except for
the express warranties set forth in this Section 4, it has accepted the license
and delivery of the IDX Licensed Technology "AS IS" and "WITH ALL FAULTS."  With
respect to Software Updates and Support Services the warranties are as follows:

4.1  Encumbrances. The IDX Software Updates shall be free and clear of all
     liens, restrictions, claims, charges, security interests, or other
     encumbrances of any nature whatsoever which might affect or adversely
     impact on ChannelHealth's use of the IDX Software Updates as permitted
     under this Agreement.

4.2  Ownership; Right to License. IDX owns or otherwise has adequate rights to
     make the grants of the licenses to the IDX Software Updates to
     ChannelHealth hereunder and possesses all rights and interests in the IDX
     Software Updates necessary to enter into this Agreement.

4.3  No Infringement. IDX Software Updates and all components thereof do not
     infringe upon the intellectual property rights, including without
     limitation the patent, copyright, trademark or trade secret rights, of any
     third parties.  The sole and exclusive remedy for breach of this warranty
     shall be as set forth in Section 8.1.

5.   CHANNELHEALTH LICENSE GRANTS AND CONVEYANCE OF INTELLECTUAL PROPERTY

     ChannelHealth grants licenses to IDX as set forth in this Section 5.

5.1  License to ChannelHealth Licensed Technology.  ChannelHealth hereby grants
     to IDX a perpetual, non-exclusive, non-cancellable and non-terminable,
     fully paid-up license to copy, use, display, perform, market, sublicense,
     transmit, create and own derivative works, and distribute (including
     through one or more Distribution Partners) all or any portion of the
     ChannelHealth Licensed Technology the use of which is limited to use with
     the Patient Channel.

5.2  Delivery. ChannelHealth shall deliver one copy (in both object code and
     Source Code forms) of each component of the ChannelHealth Licensed
     Technology.

5.3  Bankruptcy. All rights and licenses granted under or pursuant to this
     Agreement by ChannelHealth to IDX are, and shall otherwise be deemed to be,
     for purposes of Section 365(n) of the United States Bankruptcy Code (the
     "Code"), licenses to rights to "intellectual property" as defined in the
     Code. The parties agree that IDX, as licensee of such rights under this
     Agreement, shall retain and may fully exercise all of its rights and
     elections under the Code. The parties further agree that, in the event of
     the commencement of bankruptcy proceeding by or against

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     ChannelHealth under the Code, IDX shall be entitled to retain all of its
     rights under this Agreement.

6.   LIMITED WARRANTIES OF CHANNELHEALTH

     Except for the warranties made in the Merger Agreement, there are NO
WARRANTIES made by ChannelHealth in connection with the subject matter of this
Agreement.  The warranties of ChannelHealth set forth below are made only to IDX
and shall be true as of the Reference Date. IDX acknowledges that, except for
the express warranties set forth in this Section 6, it has accepted the license
and delivery of the ChannelHealth Licensed Technology "AS IS" and "WITH ALL
FAULTS."  With respect to Software Updates and Support Services the warranties
are as follows:

6.1  Encumbrances. The ChannelHealth Software Updates shall be free and clear of
     all liens, restrictions, claims, charges, security interests, or other
     encumbrances of any nature whatsoever which might affect or adversely
     impact IDX's use of the ChannelHealth Software Updates as permitted under
     this Agreement.

6.2  Ownership; Right to License. ChannelHealth owns or otherwise has adequate
     rights to make the grants of the licenses to the ChannelHealth Software
     Updates to IDX hereunder and possesses all rights and interests in the
     ChannelHealth Software Updates necessary to enter into this Agreement.

6.3  No Infringement. ChannelHealth Software Updates and all components thereof
     do not infringe upon the intellectual property rights, including without
     limitation the patent, copyright, trademark or trade secret rights, of any
     third parties.  The sole and exclusive remedy for breach of this warranty
     shall be as set forth in Section 8.1.

7.   SUPPORT AND SERVICES

7.1  IDX Support.  During the IDX Support Term, IDX shall provide to
     ChannelHealth IDX Software Maintenance and IDX Software Updates on a timely
     basis.  IDX shall have no obligation to provide any services to support,
     maintain or update CMS.

7.2  ChannelHealth Support.  During the ChannelHealth Support Term,
     ChannelHealth shall provide ChannelHealth Maintenance and ChannelHealth
     Updates on a timely basis.

7.3  Implementation and Consulting.  Each party will provide services for
     customer specific implementation work and consulting services to the other
     party at the then current consulting rate for the party.

7.4  Level of Support.  Each party will further provide the other with the same
     level of support that is offered to its customers for the specific product
     for which support is requested.

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8.   INDEMNIFICATION

8.1  IDX Indemnity.

     8.1.1  Indemnification Obligations. IDX, at its own expense, shall defend,
            hold harmless and indemnify ChannelHealth, its officers, directors,
            employees, agents, successors, affiliates, and assigns, from and
            against any and all loss, damages, expenses (including attorneys'
            fees) arising from claims of third parties that the IDX Software
            Updates, or any component thereof, whether used alone or in
            combination with any other item as intended, designed, suggested or
            induced by IDX or its agents, infringes or violates any patents,
            copyrights, trademarks, trade secrets, licenses, or other
            proprietary rights of any third party. ChannelHealth may, at its own
            expense, assist in such defense if it so chooses, provided that IDX
            shall control such defense and all negotiations relative to the
            settlement of any such claim. IDX shall not settle any claim that
            adversely affects any rights of ChannelHealth without
            ChannelHealth's prior written consent. ChannelHealth shall promptly
            provide IDX with written notice of any claim that ChannelHealth
            believes falls within the scope of this Section 8.1.1. At any time
            after IDX becomes aware of any such claim under this Section 8.1.1,
            or in the event that the IDX Licensed Technology, the IDX Software,
            or any portion thereof, is held to constitute an infringement or its
            use is enjoined, IDX shall have the option at its own expense to (i)
            modify the infringing item without impairing in any material respect
            the functionality or performance, so that it is non-infringing, (ii)
            procure for ChannelHealth the right to continue to use the
            infringing item or (iii) replace the infringing item with an equally
            suitable, non-infringing item.

     8.1.2  Exceptions. IDX's obligations to indemnify as set forth in this
            Section 8 shall not apply to any claim to the extent that it arises
            from (i) any modifications, changes, additions, or enhancements to
            the IDX Software Updates that have not been made directly by IDX or
            have not been made at its express direction or under its direct
            oversight, control or supervision or (ii) any such modifications
            made by IDX at the request or to the specification of ChannelHealth,
            ChannelHealth's Customers, or any of their agents.

8.2  ChannelHealth Indemnity.

     8.2.1  Indemnification Obligations. ChannelHealth, at its own expense,
            shall defend, hold harmless and indemnify IDX, its officers,
            directors, employees, agents, successors, affiliates, and assigns,
            from and against any and all loss, damages, expenses (including
            attorneys' fees) arising from claims of third parties that the
            ChannelHealth Updates, or any component thereof, whether used alone
            or in combination with any other item as intended, designed,
            suggested or induced by ChannelHealth or its

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            agents, infringes or violates any patents, copyrights, trademarks,
            trade secrets, licenses, or other proprietary rights of any third
            party.

     8.2.2  Exceptions. ChannelHealth's obligations to indemnify as set forth in
            this Section shall not apply to any claim to the extent that it
            arises from (i) any modifications, changes, additions, or
            enhancements to the ChannelHealth Updates that have not been made
            directly by ChannelHealth or have not been made at its express
            direction or under its direct oversight, control or supervision,
            (ii) any such modifications made by ChannelHealth at the request or
            to the specification of IDX or any of its agents, or (iii) the use
            of the ChannelHealth Updates in combination with any other item, or
            in any system or method adopted, permitted, induced, contributed to,
            or otherwise used by IDX or IDX Customers that is not marketed,
            recommended, enabled, contributed to, or otherwise directly or
            indirectly suggested by ChannelHealth.

9.   LIMITATION OF LIABILITY.

     NEITHER PARTY SHALL BE LIABLE TO THE OTHER EXCEPT FOR (i) INDEMNIFICATION
OBLIGATIONS PURSUANT TO SECTION 8 OF THIS AGREEMENT, (ii) THIRD-PARTY CLAIMS FOR
PROPERTY DAMAGE, PERSONAL INJURY OR DEATH, AND OTHER CLAIMS FOR WHICH EITHER
PARTY MAY BE ENTITLED TO INDEMNIFICATION OR CONTRIBUTION FROM THE OTHER PURSUANT
TO THIS AGREEMENT OR AS A MATTER OF LAW, AND (iii) ANY MATERIAL BREACH BY EITHER
PARTY OF ANY WARRANTY SET FORTH IN SECTIONS 4 AND 6 OF THIS AGREEMENT.

10.  CONFIDENTIALITY.

10.1 Confidentiality. IDX will receive or learn from ChannelHealth, and
     ChannelHealth's parents, subsidiaries and affiliates, and ChannelHealth
     will learn from IDX, and IDX's parents, subsidiaries and affiliates,
     information, both orally and in writing, concerning the business of
     ChannelHealth or IDX, respectively, including, without limitation,
     financial, technical and marketing information, data, and information
     related to the development of technology and services relating to
     ChannelHealth's and IDX's business, as the case may be, and the IDX
     Licensed Technology and Allscripts Products, which information is, in the
     case of ChannelHealth, proprietary to ChannelHealth and, in the case of
     IDX, proprietary to IDX. Both parties hereby agree, as set forth below, to
     protect such information, whether furnished before, on or after the date of
     this Agreement, as it protects its own similar confidential information,
     but never less than commercially reasonable efforts, and not to disclose
     such information to anyone except as otherwise provided for in this
     Agreement. Such information, in whole or in part, together with analyses,
     compilations, programs, reports, proposals, studies or any other
     documentation prepared by the parties, as the case may be, which contain or

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     otherwise reflect or make reference to such information, is hereinafter
     referred to as "Confidential Information." Both parties hereby agree that
     the Confidential Information will be used solely for the purpose of this
     Agreement and not for any other purpose. Both parties further agree that
     any Confidential Information pertaining to the other party is the sole and
     exclusive property of such other party, and that the receiving party shall
     not have any right, title, or interest in or to such Confidential
     Information except as expressly provided in this Agreement. Both parties
     further agree to protect and not to disclose to anyone (except as provided
     in this Agreement) for any reason Confidential Information pertaining to
     the other party; provided, however, that: (a) such Confidential Information
     may be disclosed to the receiving party's respective officers, directors,
     employees, agents, or representatives (collectively, our "Representatives")
     on a "need to know" basis for the purpose of this Agreement on the
     condition that (i) each such Representative will be informed by the
     receiving party of the confidential nature of such Confidential Information
     and will agree to be bound by the terms of this Agreement and not to
     disclose the Confidential Information to any other person and (ii) both
     parties agree to accept full responsibility for any breach of this Section
     10 by its respective Representatives; and (b) Confidential Information
     pertaining to the other party may be disclosed upon the prior written
     consent of the other party. Both parties hereby agree, upon the request of
     the other party, to promptly deliver to the other party at its cost the
     Confidential Information pertaining to such other party, without retaining
     any copies thereof. Specifically and without limitation, ChannelHealth
     agrees to (i) reproduce (and refrain from removing or destroying) copyright
     and proprietary rights notices which are placed on the IDX Licensed
     Technology or the Allscripts Products, (ii) erase or otherwise destroy,
     prior to disposing of media, all portions of IDX Licensed Technology or the
     Allscripts Products contained on such media, (iii) notify the other party
     promptly in writing upon any officer or director learning of any
     unauthorized disclosure or use of the IDX Licensed Technology or the
     Allscripts Products and (iv) reasonably cooperate with the other party to
     cure any unauthorized disclosure or use of the IDX Licensed Technology or
     the Allscripts Products.  IDX agrees that ChannelHealth's use and
     distribution of the IDX Licensed Technology pursuant to and in accordance
     with the terms of this Agreement shall not be a violation of this Section
     10.1.

10.2 Non-Confidential Information. The term "Confidential Information" shall not
     include any information: (i) which at the time of disclosure or thereafter
     is generally available to or known by the public (other than as a result of
     a disclosure directly or indirectly by the receiving party); (ii) is
     independently developed by the receiving party, without reference to or use
     of, the Confidential Information of the other party; (iii) was known by the
     receiving party as of the time of disclosure without a breach of
     confidentiality; (iv) is lawfully learned from a third party not under
     obligation to the disclosing party; or (v) is required to be disclosed
     pursuant to a subpoena, court order or other legal process, whereupon the
     receiving party shall provide prompt written notice to the other party
     prior to such disclosure.

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11.  GENERAL

11.1 Force Majeure. Except as expressly provided to the contrary in this
     Agreement, neither party shall be liable to the other for any delay or
     failure to perform due to causes beyond its reasonable control. Performance
     times shall be considered extended for a period of time equivalent to the
     time lost because of any such delay.

11.2 Non-revocation.  The licenses, immunities, authorities and agreements set
     forth in Sections 3 and 5 hereof, once effective, are not terminable,
     cancelable, or revocable.

11.3 Notices. Wherever under this Agreement one party is required or permitted
     to give notice to the other, such notice shall be deemed given when
     delivered in hand, when telecopied or faxed and receipt confirmed, when
     sent by overnight courier service to the address specified below, or when
     mailed by United States mail, registered or certified mail, return receipt
     requested, postage prepaid, and addressed as follows:

     (a)  if to IDX:

          IDX Systems Corporation
          1400 Shelbourne Road
          South Burlington, VT 05043
          Attention:  President
          Facsimile: (802) 862-6351

          with a copy to:  General Counsel at same address

     (b)  if to ChannelHealth

          ChannelHealth Incorporated
          25 Green Mountain Drive
          P. O. Box 8370
          Burlington, VT  05402-8370
          Attention:  Jeffrey J. McMahan
          Facsimile: (802) 865-1197

          with copies to:

          Allscripts Healthcare Solutions, Inc.
          2401 Commerce Drive
          Libertyville, Illinois  60048
          Attention:  President
          Facsimile:  (847) 680-3721

          and

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            Weil, Gotshal & Manges LLP
            700 Louisiana, Suite 1600
            Houston, Texas 77002
            Attention: Steven D. Rubin
            Facsimile: (713) 224-9511

      Either party hereto may from time to time change its address for
      notification purposes by giving the other written notice of the new
      address and the date upon which it will become effective.

11.4  Governing Law. This Agreement shall be governed by, subject to, and
      interpreted in accordance with the laws of the State of Delaware, without
      regard to its conflicts of laws principles.

11.5  Severability. In the event any provision hereof shall be deemed invalid or
      unenforceable by any court or governmental agency, such provision shall be
      deemed severed from this Agreement and replaced by a valid provision which
      approximates as closely as possible the intent of the parties. All
      remaining provisions shall be afforded full force and effect.

11.6  No Waiver. No delay or omission by either party hereto to exercise any
      right or power hereunder shall impair such right or power or be construed
      to be a waiver thereof. A waiver by either of the parties hereto of any of
      the covenants to be performed by the other or any breach thereof shall not
      be construed to be a waiver of any succeeding breach thereof or of any
      other covenant herein contained.

11.7  Further Assurances and Documents. IDX and ChannelHealth shall take all
      actions and do all things, including without limitation the execution and
      delivery of instruments and documents, necessary to effectuate the
      purposes and intent of this Agreement.

11.8  Independent Contractor. In performance of this Agreement, each party is
      acting as an independent contractor. Personnel supplied by a party
      hereunder are not the other party's personnel or agents, and each party
      assumes full responsibility for their acts. Each party shall be solely
      responsible for the payment of compensation to its employees and
      subcontractors assigned to perform services hereunder, and such employees
      and subcontractors shall be informed that they are not entitled to the
      provision of any employee benefits of the other party. Neither party shall
      be responsible for payment of workers' compensation, disability benefits,
      unemployment insurance or for withholding income taxes and social security
      for any employee or subcontractor of the other.

11.9  Personnel Rules and Regulations. The personnel and subcontractors of each
      party hereto shall comply with the other party's security regulations
      particular to each work location, including any procedures which such
      party's personnel and other consultants are normally asked to follow.
      Personnel and subcontractors, when deemed appropriate by a party, shall be
      issued visitor identification cards. Each such card will be surrendered by
      such personnel and subcontractors upon demand of a party. Unless otherwise
      agreed to by the parties, the personnel and

                                       12
<PAGE>

       subcontractors of a party shall observe the working hours, working rules
       and holiday schedules of the other party while working on the other
       party's premises.

11.10  Assignment. This Agreement shall be binding upon the parties and their
       respective successors, representatives and permitted assigns and their
       Affiliates, respectively. Neither party may assign this Agreement without
       the prior written consent of the other party, except that either party
       hereto may assign its rights hereunder to an Affiliate of such party and
       either party may, without the consent of the other party, assign and
       delegate this Agreement and its rights and obligations hereunder in
       connection with a merger, consolidation or sale of substantially all of
       its assets (which sale shall include the assignment and assumption of all
       rights and obligations under the License Agreement); provided, however,
                                                             --------  -------
       that such assignee or transferee shall assume all obligations of the
       assigning or transferring party and any such assignment shall not relieve
       the assigning or transferring party of its obligations hereunder.

11.11  Availability of Records. IDX and ChannelHealth agree that the Secretary
       of the Department of Health and Human Services (the "Secretary") and the
       Comptroller General of the United States, or the designee or duly
       authorized representative of either of them, shall have access to all
       books and records of each party pertaining to the subject matter of this
       Agreement and the provisions of services under it, in accordance with the
       criteria presently or hereafter developed by the Department of Health and
       Human Services as provided in Section 952 of the Omnibus Reconciliation
       Act of 1980 (the "Act"). Upon request of the Secretary, the Comptroller
       General, or the designee or authorized representative of either of them,
       IDX and ChannelHealth shall make available (at reasonable times and
       places during normal business hours) this Agreement, and all books,
       documents and records of IDX and ChannelHealth that are necessary to
       verify the nature and extent of the costs of the services provided by IDX
       or ChannelHealth furnished in connection with this Agreement.
       Notwithstanding the foregoing provisions, the access to the books,
       records and documents of IDX and ChannelHealth and any related
       organization provided for herein shall be discontinued and become null
       and void upon a finding by a court or quasi-judicial body of competent
       jurisdiction that this Agreement is outside the scope of the regulatory
       or statutory definition of those contracts and agreements included within
       the purview of Section 952 of the Act or the rules and regulations
       promulgated thereunder.

11.12  Survival.  Section 10 shall survive the termination of this Agreement.

11.13  Entire Agreement.  This Agreement constitutes the entire sum of changes
       of any kind or nature to the License Agreement, and there are no changes,
       representations, warranties, covenants or obligations of any kind except
       as set forth herein. This Agreement supersedes all prior and
       contemporaneous agreements, understanding, negotiations and discussions,
       written or oral, of the parties hereto, relating to any transaction
       contemplated by this Agreement. There have been no changes to any other
       agreement entered in to in connection with the License Agreement, unless
       reduced to writing and made a part of an addendum to such other
       agreement. Except as otherwise especially provided herein, nothing in
       this Agreement is intended or shall be construed to confer upon or to
       give any

                                       13
<PAGE>

       person other than the parties hereto any rights or remedies under or by
       reason of this Agreement.

11.14  Binding Effect.  This Agreement shall be binding upon and shall inure to
       the benefit of the parties hereto and their respective successors and
       permitted assigns.

11.15  Amendments.  This Agreement may be amended only in writing executed by
       the parties affected by such amendment.

                                       14
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have signed this Agreement the date
and year first written above by their fully authorized representatives.

IDX SYSTEMS CORPORATION                      CHANNELHEALTH INCORPORATED

By:   /s/ Robert W. Baker, Jr.               By:  /s/ Robert W. Baker, Jr.
   ------------------------------------         --------------------------------
   Robert W. Baker, Jr.                         Robert W. Baker, Jr.
   Vice President and General Counsel           Vice President

                                       15
<PAGE>

                                  SCHEDULE 1

                                  DEFINITIONS

"Allscripts" means Allscripts Healthcare Solutions, Inc., a Delaware
corporation.

"Affiliate" means, with respect to any specified Person, any other Person that
directly, or indirectly through one or more intermediaries, controls, is
controlled by, or is under common control with, such specified Person.

"Agreement" means this Amended and Restated Cross License and Software
Maintenance Agreement, including all schedules, exhibits another items attached
hereto and incorporated by reference herein.

"Allscripts Products" means the products and services (i) offered by Allscripts
as more fully described in the Development Plan, (ii) the Physician Channel
Products as of the Closing Date and (iii) all of the products and services to be
developed as set forth under the Development Plan.

"ChannelHealth" means Channelhealth Incorporated, a Delaware corporation, its
successors and assigns, and any other entity which, as of the Closing, Controls,
is Controlled by, or is under common Control with ChannelHealth.

"ChannelHealth Licensed Technology" means (i) the object and Source Code for the
ChannelHealth Works, (ii) ChannelHealth Updates, (iii) the standard, published
editions of textual and graphical works, in whatever form, intended to instruct
users in the use of ChannelHealth Works, and published by ChannelHealth from
time to time during the ChannelHealth Support Term, and (iv) the intellectual
property rights of ChannelHealth, including without limitation patent rights and
copyrights, embodied or contained in the items named in clauses (i) through
(iii).

"ChannelHealth Maintenance" means services to correct errors found in the
ChannelHealth Works and delivered during the ChannelHealth Support Term.

"ChannelHealth Support Term" means the period commencing with the Effective Time
and ending on the expiration of the Initial Term of the Strategic Alliance
Agreement or later if renewed as set forth in this Agreement.

"ChannelHealth Updates" means all additions, corrections, and modifications to
the ChannelHealth Works provided as part of ChannelHealth Maintenance and all
standard new releases, new versions, and updates to the ChannelHealth Works
delivered by ChannelHealth to its customers generally as part of the
ChannelHealth Works during the ChannelHealth Support Term.

"ChannelHealth Works" means the products and works of ChannelHealth known as
"WebWorks Task Engine," "Task Engine Database," "My Health" and "Patient
Messaging" (also known as Secure Messaging).

                                       16
<PAGE>

"Clinical Management System" or "CMS" means the product formerly marketed by IDX
under the trademark of "CMS" or "Clinical Management System," including its
predecessor product known as "CRS."

"Closing" means the closing of the acquisition by Allscripts of all of the
issued and outstanding capital stock of ChannelHealth pursuant to the Merger
Agreement.

"Closing Date" means the date on which the Closing occurs.

"ConnectR" means the product currently marketed by IDX under the trademark
"ConnectR."

"Core Application" means any software application expressly designed to automate
the business processes of physician billing, physician scheduling, managed care
contract administration, hospital clinical practice, hospital patient
administration, or hospital billing, including by way of example and not in
limitation, as embodied in the products currently marketed by IDX under the
trademarks "IDXtendR," "IDXSite" and "LastWord."

"Development Plan" has the meaning specified in Section 4 of the Strategic
Alliance Agreement.

"DietSite" means the product consisting of the World Wide Web site on the
Internet at www.dietsite.com, and all content and services available therein,
            ----------------
and all future versions thereof.

"Direct Competitor of IDX" means any Person that develops or markets any Core
Application.

"Distribution Partner" means any Person that has the right to distribute,
resell, sublicense, license, sell or otherwise provide a party's products or
services, including by way of example and not in limitation, any reseller,
distributor, licensee, customer, contractor, service provider, outsourcing
vendor or other information technology company.

"eCommerce Channel" means the service currently marketed by IDX under the
service mark "eCommerce Channel."

"Effective Time" means the time of completion of the Closing.

"Enterprise Index" means the product currently marketed by IDX under the
trademark of "Enterprise Index."

"IDX Database Information" means information concerning the file structure or
definition of any IDX Products that would be necessary or useful in using
Integration Methods.

"IDX Licensed Technology" means (i) the IDX Software, including the object and
Source Code therefor, as of the Reference Date, (ii) IDX Software Updates, (iii)

                                       17
<PAGE>

Integration Methods as of the Reference Date, and (iv) the intellectual property
rights of IDX, including without limitation patent rights (including patent
rights owned by IDX with claims in part or wholely directed to inventions
embodied in, or necessary to implement and practice the Physician Channel alone,
or in combination with any other product or service, invented by former IDX
employees that are now ChannelHealth employees), copyrights, and trade secrets
embodied or contained in the items named in clauses (i) through (iii).

"IDX Names and Marks" means trade names, trademarks, service names and service
marks used by IDX in marketing any of its products and services.

"IDX Products" means all products and services offered by IDX from time to time
during the term of this Agreement, whether or not described in the License
Agreement or the Strategic Alliance Agreement, including without limitation all
(i) computer software and (ii) computerized or automated products, services,
processes, systems, and methods of any kind or nature.

"IDX Software" means (i) the Web FrameWork, (ii) ConnectR, (iii) OutReach, (v)
CMS, (v) Enterprise Index, and (vi) the standard, published editions of textual
and graphical works, in whatever form, intended to instruct users in the use of
the software products named in clauses (i) through (vi) and published by IDX
from time to time during the IDX Support Term.

"IDX Software Maintenance" means services to correct errors found in the IDX
Software, except CMS and OutReach, and delivered during the IDX Support Term as
set forth in this Agreement.

"IDX Software Updates" means all additions, corrections, and modifications to
the IDX Software provided as part of IDX Software Maintenance and all standard
new releases, new versions, and updates to the IDX Software delivered by IDX to
its customers generally as part of the IDX Software during the IDX Support Term.
IDX Software Updates include New Enabling Technologies only to the extent
necessary to achieve compatibility between IDX Products and ChannelHealth Works.

"IDX Support Term" means the period commencing with the Effective Time and
ending on the expiration of the Initial Term of the Strategic AllianceAgreement
or later if renewed as set forth in this Agreement.

"Integration Method" means any method using any programmatic or computerized
means, such as a program or data interface (including without limitation
OutReach and ConnectR), for extracting or adding to any databases included in
any IDX Product or exchanging any data between any IDX Product and any
ChannelHealth Product.

"Merge" means the process of merging all or a portion of existing software or
documentation into other software or documentation or adding to existing
software or documentation so that the resulting software or documentation
contains functionality that is substantially more or different from that of the
existing software or documentation. For

                                       18
<PAGE>

purposes of illustration, the IDX Software shall be deemed to have been Merged
into the ChannelHealth Division Works.

"Merger Agreement" means the Agreement and Plan of Merger, dated as of July 13,
2000, by and among Allscripts (formerly named Allscripts Holding, Inc.),
Allscripts, Inc., Bursar Acquisition, Inc., Bursar Acquisition No. 2, Inc., IDX
and ChannelHealth.

"New Enabling Technologies" means tools and other means for building products
and integration methods (similar to the Integration Methods) developed by IDX
and incorporated by IDX into IDX Software Updates after the  Effective Time.
Examples of New Enabling Technologies that may at IDX's election be embodied in
IDX Software Updates are the items currently referred to by IDX as "IDX
Objects," "IDXml," and "Tabasco."

"OutReach" means the product currently marketed by IDX under the trademark
"OutReach."

"Patient Channel" means the service currently marketed by ChannelHealth under
the service mark "Patient Channel."

"Person" means any individual, partnership, firm, corporation, association,
trust, limited liability company, limited liability partnership, unincorporated
organization or other entity, as well as any syndicate or group that would be
deemed to be a person under Section 13(d)(3) of the Securities Exchange Act of
1934, as amended.

"Physician Channel" means the service currently marketed by ChannelHealth under
the service mark "Physician Channel" and the technical components consisting of
CMS, EdiXpress, ChangeWorks, DocWorks, ResultWorks, WebWorks, OrderWorks,
NoteWorks, MedWorks, Physician Homebase and "Project PotatoHead."

"Reference Date" means January 1, 2000.

"Source Code" means the human readable programming statements comprising
software, together with such available programmer notes, specifications,
schematics, file definitions (including without limitation IDX Database
Information) and other documentation that would be necessary for a programmer of
ordinary skill to understand, use and Merge the IDX Software.

"Strategic Alliance Agreement" means that certain agreement entitled "Strategic
Alliance Agreement" by and between Allscripts and IDX executed or intended to be
executed on the Closing Date.

"Web FrameWork" means the product currently marketed by IDX under the trademark
"IDX Web FrameWork" and as more fully described in the Development Plan.

                                       19
<PAGE>

                                 EXHIBIT 3.4.1

                                    FORM OF

                             COPYRIGHT ASSIGNMENT

     For good and valuable consideration, receipt of which is hereby
acknowledged, the below-named Assignor has assigned and does hereby assign and
transfer to CHANNELHEALTH INCORPORATED, a Delaware corporation with offices at
25 Green Mountain Drive, South Burlington, Vermont 05403 ("Assignee", herein),
Assignor's entire right, title and interest in and to any and all Copyrights in
those certain software products known as "Clinical Management System" and
"Physician Channel" (as defined in the Amended and Restated Cross License and
Software Maintenance Agreement by and between Assignor and Assignee dated
January 8, 2001), and any and all modules, portions, works of authorship,
computer programs, code, databases, programmer notes, documentation, Moral
Rights or other works contained therein or related thereto (the "Works").

     For purposes herein, "Copyrights" includes all copyrights throughout the
world including all extensions, renewals and continuations thereof, whether
common law, statutory or otherwise, in the Works, together with the exclusive
right to obtain and register the copyright and to renew copyright protection in
the Works, whether in the name of the Assignee or otherwise, and the right to
bring suit thereunder. For purposes herein, the term "Moral Rights" includes,
without limitation, the right to be known as the author, the right to object to
any alterations to a work, the right to prevent others from being named as the
author of a work, the right to prevent others from falsely attributing to one
the authorship of work that one has not in fact written, the right to prevent
others from making deforming changes in a work, the right to withdraw a
published work from distribution if it no longer represents the views of the
author, and the right to prevent others from using a work or the author's name
in such a way as to reflect on the author's professional standing. Assignor
furthermore waives and agrees never to assert any Moral Rights assignor may have
in the Works.

     Assignor agrees that on request and without further consideration, but at
the expense of Assignee, Assignor will communicate to the Assignee or its
representatives or nominees any facts known to the Assignor respecting said
Copyrights, and will testify in any legal proceeding, sign all lawful papers,
execute all applications and confirmations, make all rightful oaths and
generally do everything possible to  aid the Assignee, its successors, assigns
and nominees to obtain, maintain, perfect, and enforce rights in the Copyrights.

     Signed and sealed this 8/th/ day of January, 2001.

                                       20
<PAGE>

Print or type Assignor's name and address:    SIGNATURE (NOTARIZED)

IDX INVESTMENT CORPORATION                    By   /s/ Robert W. Baker, Jr.
-------------------------------                 --------------------------------
1400 Shelburne Road
-------------------------------
South Burlington, Vermont 05403               If Assignor is an entity other
-------------------------------
individual,                                   than an

_______________________________               provide name and title of person
signing:

_______________________________               NAME: Robert W. Baker, Jr.

_______________________________               TITLE: Vice President

STATE OF VERMONT

COUNTY OF CHITTENDEN

     On this 8/th/ day of January, 2001, before me personally appeared Robert W.
Baker, Jr. personally known to me to be the person whose name is subscribed to
the within instrument, and acknowledged to me that he executed the same of his
own free will for the purposes therein set forth.

Notary Public
(Notary's Seal)

                                       21<PAGE>   1
                                                                   EXHIBIT 10.30

                    AMENDMENT TO SPONSORED RESEARCH AGREEMENT

       This is the first Amendment, signed on December 6, 2000 (hereinafter the
"Effective Date of the Amendment"), to the Sponsored Research Agreement dated
June 24, 1999 (hereinafter "the AGREEMENT', attached as Exhibit B to this
Amendment) by and between CHILDREN'S HOSPITAL, a corporation organized and
existing under the laws of the Commonwealth of Massachusetts and having its
principal place of business at 300 Longwood Avenue, Boston, MA 02115
(hereinafter "HOSPITAL"), and ENTREMED, INC., a corporation organized and
existing under the laws of Delaware, and having its principal place of business
at 9640 Medical Center Drive, Rockville, MD 20850 (hereinafter "ENTREMED").

HOSPITAL and ENTREMED mutually desire to amend the AGREEMENT as follows:

       I.     All capitalized terms herein are defined as in the AGREEMENT,
              unless otherwise specified herein.

       2.     In Paragraph 1(a) of the AGREEMENT, "Exhibit A" is replaced with
              "Amended Exhibit A", which Amended Exhibit A is attached hereto as
              Exhibit A to this Amendment.

       3.     In Paragraph 2(a) of the AGREEMENT, "September 29, 2000" is
              replaced with "September 29, 2001".

       4.     Paragraphs 4(a) and (b) of the AGREEMENT are amended to add the
              following sentence to each respective paragraph:

              (a)    In addition, EntreMed agrees to pay Hospital One Million
                     Five Hundred Thousand Dollars ($1,500,000) to fund the
                     Program in accordance with the conditions and terms of this
                     Agreement, as amended.

              (b)    In addition, on October 4, 2000, EntreMed will pay Hospital
                     the sum of $750,000 and thereafter will make one additional
                     payment of $750,000 on March 29, 2001 in accordance with
                     the conditions and terms set forth herein.

       5.     Paragraph 7(b) of the AGREEMENT is deleted and the following
              Paragraph 7(b) is substituted therefor:

              (b)    Hospital shall apply for, seek prompt issuance of, and
                     maintain during the term of this Agreement the patent
                     applications and patents covering Inventions and
                     jointly-owned inventions. Hospital shall solicit EntreMed's
                     comment prior to filing of patent applications and prior to
                     any significant actions required during such filing,
                     prosecution, and maintenance and shall provide EntreMed
                     with drafts of responses sufficiently in advance to allow
                     time for comment and with file copies

<PAGE>   2

                     after the action is completed. Significant actions shall
                     include Hospital's submission of patent applications, all
                     official actions from the patent office and all responses
                     to official actions. Hospital agrees to seriously consider
                     EntreMed's comments with regard to patent prosecution. If
                     Hospital decides not to file, not to continue prosecution
                     or not to maintain any patent application or patent
                     covering Inventions and jointly-owned inventions in any
                     jurisdiction, the Intellectual Property Office of Hospital
                     will notify EntreMed in a timely fashion. Following receipt
                     of any such notice from the Intellectual Property Office of
                     Hospital, EntreMed may thereafter elect to file, continue
                     prosecution, or maintain the patent application or patent
                     that is the subject of such notice, at its own expense and
                     in the name of Hospital. EntreMed shall solicit Hospital's
                     comment prior to the filing of patent applications and
                     prior to any significant actions required during such
                     filing, prosecution, and maintenance and shall provide
                     Hospital with drafts of responses sufficiently in advance
                     to allow time for comment and with file copies after the
                     action is completed. Significant actions shall include
                     EntreMed's submission of patent applications, all official
                     actions from the patent office and all responses to
                     official actions, EntreMed agrees to seriously consider
                     Hospital's comments with regard to patent prosecution.
                     Payment of all reasonable fees and costs incurred by
                     Hospital relating to the filing, prosecution, and
                     maintenance of the patent applications and patents covering
                     Inventions and jointly-owned inventions shall be the
                     responsibility of EntreMed. If EntreMed elects not to pay
                     any such fees and costs with respect to any patent
                     application or parent in any jurisdiction, Hospital shall
                     have the right to file, continue prosecution or maintain
                     such patent application or patent in such jurisdiction at
                     its own expense as it deems necessary and EntreMed shall
                     have no further option or other rights to such patent
                     application or patent in such jurisdiction.

       6.     In Exhibit B to the AGREEMENT (the Model License Agreement),
              Sections 1.4.3, 1.4.4 and 1.4.5 shall be deleted and the following
              sections are substituted therefor:

              1.4.3. Claims of U.S. and foreign continuation-in-part
                     applications, and of the resulting patents, which are
                     directed to subject matter that is described in the U.S.
                     and foreign applications listed in Appendix A in a manner
                     that meets the requirements of 35 U.S.C. Section 112;

              1.4.4. Claims of all later filed foreign patent applications, and
                     of the resulting patents, which are directed to subject
                     matter that is described in the U.S. patents and/or patent
                     applications listed in Appendix A in a manner that meets
                     the requirements of 35 U.S.C. Section 112;

              1.4.5  Any reissues of United States patents described in
                     paragraphs 1.4.1,

<PAGE>   3

                     1.4.21.4.3 and 1.4.4 above.

       7.     In Exhibit B to the AGREEMENT, in Sections 4.6 and 5.4,
              "BankBoston" is replaced with "FleetBoston Financial".

       8.     Also in Exhibit B to the AGREEMENT, Sections 6.1 and 6.2 shall be
              deleted and the following sections are substituted therefor:

              6.1    Hospital shall apply for, seek prompt issuance of, and
                     maintain during the term of this Agreement the patent
                     applications and patents covering Inventions and
                     jointly-owned inventions. Hospital shall solicit EntreMed's
                     comment prior to filing of patent applications and prior to
                     any significant actions required during such filing,
                     prosecution, and maintenance and shall provide EntreMed
                     with drafts of responses sufficiently in advance to allow
                     time for comment and with file copies after the action is
                     completed. Significant actions shall include Hospital's
                     submission of patent applications, all official actions
                     from the patent office and all responses to official
                     actions. Hospital agrees to seriously consider EntreMed's
                     comments with regard to patent prosecution. If Hospital
                     decides not to file, not to continue prosecution or not to
                     maintain any patent application or patent covering
                     Inventions and jointly-owned inventions in any
                     jurisdiction, the Intellectual Property Office of Hospital
                     will notify EntreMed in a timely fashion. Following receipt
                     of any such notice from the Intellectual Property Office of
                     Hospital, EntreMed may thereafter elect to file, continue
                     prosecution, or maintain the patent application or patent
                     that is the subject of such notice, at its own expense and
                     in the name of Hospital. EntreMed shall solicit Hospital's
                     comment prior to the filing of patent applications and
                     prior to any significant actions required during such
                     filing, prosecution, and maintenance and shall provide
                     Hospital with drafts of responses sufficiently in advance
                     to allow time for comment and with file copies after the
                     action is completed. Significant actions shall include
                     EntreMed's submission of patent applications, all official
                     actions from the patent office and all responses to
                     official actions, EntreMed agrees to seriously consider
                     Hospital's comments with regard to patent prosecution.
                     Payment of all reasonable fees and costs incurred by
                     Hospital relating to the filing, prosecution, and
                     maintenance of the patent applications and patents covering
                     Inventions and jointly-owned inventions shall be the
                     responsibility of EntreMed. If EntreMed elects not to pay
                     any such fees and costs with respect to any patent
                     application or patent in any jurisdiction, Hospital shall
                     have the right to file, continue prosecution or maintain
                     such patent application or patent in such jurisdiction at
                     its own expense as it deems necessary and EntreMed shall
                     have no further option or other rights to such patent
                     application or patent in such jurisdiction.

<PAGE>   4

              6.2    Payment of all reasonable fees and costs relating to the
                     filing, prosecution, and maintenance of the patent
                     applications and patents included in Patent Rights shall be
                     the responsibility of Licensee, whether such fees and costs
                     were incurred before or after the date of this Agreement.
                     If Licensee elects not to pay for any such fees and costs
                     with respect to any patent application or patent included
                     in Patent Rights in any jurisdiction, CMCC shall have the
                     right to file, continue prosecution or maintain such patent
                     application or patent in such jurisdiction at its own
                     expense as it deems necessary and Licensee shall have no
                     further rights to such patent application or patent in such
                     jurisdiction.

       9.     The provisions of this Amendment are expressly incorporated in the
              AGREEMENT.

       10.    Any conflict between a provision in this Amendment and a provision
              in the AGREEMENT shall be resolved in favor of the provision of
              this Amendment.

       11.    This Amendment shall be deemed effective as of the Effective Date
              of the Amendment.

       12.    This Amendment may be signed in counterparts, each of which shall
              be considered an original, but all of which shall constitute one
              and the same instrument.

<PAGE>   5

       In Witness whereof, HOSPITAL and ENTREMED have caused this Amendment to
be executed on the dates indicated below:

For CHILDREN'S HOSPITAL:

Name: /s/ JAMES MANDELL
     ----------------------------------------
Title: President and Chief Executive Officer
      -------------------------------------------

Date:  December 6, 2000

For ENTREMED, INC.:

Name: /s/ JOHN HOLADAY
     ----------------------------------------
Title: Chairman and CEO
      -------------------------------------------

Date:  December 5, 2000

Name: /s/ JUDAH FOLKMAN, MD.
     --------------------------------------------
Title: Judah Folkman, M.D. Principal investigator

Date:  December 7, 2000

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