Document:

S

                                SAFESCIENCE, INC.

                             (a Nevada corporation)

                             SUBSCRIPTION DOCUMENTS:

                         PURCHASER SUITABILITY STATEMENT

                             SUBSCRIPTION AGREEMENT

<PAGE>

                                SAFESCIENCE, INC.
                            SUBSCRIPTION INSTRUCTIONS
                            -------------------------

         The documents contained in this Subscription Package are duplicates of
documents set forth as exhibits in the Private Placement Memorandum dated
October 13, 2000 (the "Memorandum"). Do not use pages from documents contained
in the Memorandum. Before signing these documents, you should carefully review
the Memorandum and consult your own counsel and accountant as to tax matters and
related matters concerning an investment in the Company. Fully complete and sign
all the documents included in this Subscription Package and then send such
documents to:

                          Bradley J. Carver, President
                                SAFESCIENCE, INC.
                               31 St. James Avenue
                                Boston, MA 02116

         1. Minimum Subscription: Generally, the minimum subscription amount is
$250,000, unless otherwise agreed to by SafeScience, Inc.

         2. Payment: Payment in full of the subscription price is due upon the
acceptance of this subscription and shall be made by check made payable to the
order of "SafeScience, Inc." or by wire transfer to _________; ABA Routing #
__________; Account # ___________; Account Name: _______________. The Company
may deposit, at its option, the proceeds from the Subscription into an account
established by the Company pending the earlier of acceptance or rejection of
such subscription or termination of the offering.

         3. Purchaser Suitability Statements: All investors, individually and
where applicable (for example in the case of trusts, pension and profit sharing
plans, IRAs and SEPs) through their duly authorized trustees, custodians or
other authorized fiduciaries, must fully complete, sign and date the Purchaser
Suitability Statement.

         4. Subscription Agreement: Two (2) copies of the form of the
Subscription Agreement are enclosed in this Subscription Package. The
Subscription Agreement contains various statements and representations and must
be read in its entirety. Both copies of the Subscription Agreement should be
completed according to the following instructions and returned with the
Purchaser Suitability Statement:

         If the Purchaser is an individual or corporation, date, sign, have
notarized and provide the information required on pages 1, 2-5 (as applicable),
6-7 (as applicable), 8, 15-16 (as applicable),and 17-20 (as applicable) of the
Subscription Agreement. A copy of the completed Subscription Agreement will be
returned to you after the subscription has been accepted by the Company.

<PAGE>

                         PURCHASER SUITABILITY STATEMENT

<PAGE>

                                SAFESCIENCE, INC.
                                -----------------

                         PURCHASER SUITABILITY STATEMENT
                         -------------------------------

         The undersigned directly, if an individual, or as partner, officer,
trustee, custodian or authorized fiduciary on behalf of the investing
corporation, partnership, trust, pension or profit sharing plan, individual
retirement arrangement ("IRA") or simplified employee retirement plan ("SEP"),
has irrevocably agreed to purchase shares of Common Stock of SafeScience, Inc.
(the "Company") for a total dollar amount of ______________. The investor or
investing entity is herein called the "Investor".

         The offer and sale of shares ("Shares") is not being registered under
the Securities Act of 1933, as amended (the "Act"), but rather is being made
privately on behalf of the Company, pursuant to the private placement exemption
from registration provided in Section 4(2) of the Act and the requirements of
certain applicable state securities laws. The undersigned acknowledges that the
information contained herein is needed by the Company in order to ensure
compliance with the requirements of the private placement exemption and to
determine (a) whether an investment in the Company by the investor is suitable
in light of the Investor's financial position, and (b) whether the Investor, or
its trustees, custodian and other authorized fiduciaries, have such knowledge
and experience in financial business matters and risks that the undersigned is
capable of evaluating the merits and risks of the investment by the Investor in
the Company.

         The undersigned also understands that (a) the Company will rely on the
information contained herein for purposes of such determination and (b) the
Shares will not be registered under the Act in reliance upon the exemption from
registration afforded by Section 4(2) of the Act, and in reliance on similar
exemptions under certain applicable state security laws.

         Accordingly, the undersigned individually and, where applicable, on
behalf of the Investor, represents and warrants to the Company that the
information contained herein is complete and accurate and may be relied upon by
the Company, and hereby agrees to notify the Company immediately if there are
any material changes in the information provided herein and to furnish to the
Company any other information which the Company may request so as to determine
the suitability of the undersigned.

         The undersigned also understands and agrees that, although the Company
will use its best efforts to keep the information provided in this Statement
strictly confidential at all times, the Company may present this Statement and
the information provided in answer to it to such parties as it deems advisable
if called upon to establish the availability under any federal or state
securities laws of an exemption from registration of the offer or sale of
Shares.

         In accordance with the foregoing, the following representations and
information are hereby made and provided by the undersigned:

<PAGE>

A.  Investor Information.
    ---------------------

1.  Individual Investors

Name: __________________________________________________

Home Phone: (____) ______________________

(a) Date of Birth: _________________________

(b) Social Security No.: ____________________

(c) Citizenship: ___________________________

(d) Home address (Post Office Boxes are not acceptable):

         ----------------------------------------------------

         ----------------------------------------------------

(e) State in which Registered to Vote: __________________________

(f) Name of Employer and Position: ____________________________

         ----------------------------------------------------

(g) Nature of Employer's Business: ____________________________

(h) How long have you been employed at
         your current position? _________________

(i) If you have had more than one job in the last five years, give the same
information with respect to each such job:

         ----------------------------------------------------

         ----------------------------------------------------

(j) Business Address: _______________________________________

         ----------------------------------------------------

(k) Business Telephone Number: (____) ___________

(l) Educational background (highest degree awarded):

         School ______________________________________________

         Degree __________________ Year Conferred ______________

                                       -2-
<PAGE>

(m) Address to which all correspondence should be sent:

         ----------------------------------------------------

         ----------------------------------------------------

2.  Partnerships, Corporations, Trusts or Other Entities (Non-ERISA)

Name of Entity:  _________________________

(a) Type of Entity:  ___________________

(b) Taxpayer Identification No.:  ___________________

(c) Date of Organization or Incorporation:  ___________________

(d) Business Address (Post Office Boxes are not acceptable):

         ----------------------------

         ----------------------------

         ----------------------------

(e) Business Telephone Number: ____________________________

(f) State or other Jurisdiction in which Organized or Incorporated:  ___________

(g) Was this partnership, corporation, trust or other entity formed for the
specific purpose of investing in the Company? Yes _____ No _____

         The information requested in paragraph A (1) above ("Individual
Investors") should also be provided in regard to the individual(s) who is making
the investment decision on behalf of the partnership, corporation, trust or
other entity.

3.  Investor's Trustee, Custodian or Fiduciary -- If Individual

Name: __________________________________________________

Home Phone: (____) ______________________

(a) Date of Birth: _________________________

(b) Social Security No.: ____________________

(c) Home address (Post Office Boxes are not acceptable):

         ----------------------------------------------------

                                      -3-
<PAGE>

         ----------------------------------------------------

(d) State in which Registered to Vote: _________

(e) Name of Employer and Position: ____________________________

         ----------------------------------------------------

(f) Nature of Employer's Business: _____________________________

(g) How long have you been employed at

your current position? _________________

(h) If you have had more than one job in the last five years, give the same
information with respect to each such job:

         ----------------------------------------------------

         ----------------------------------------------------

(i) Business Address: ________________________________________

         ----------------------------------------------------

(j) Business Telephone Number: (____) _____________

(k) Educational background (highest degree awarded):

         School ______________________________________________

         Degree __________________ Year Conferred ______________

(l) Address to which all correspondence should be sent:

         ----------------------------------------------------

         ----------------------------------------------------

4.  Investor's Trustee, Custodian or Other Fiduciaries -- If Not Individual

Name of Entity: ____________________________________________

(a) Type of Entity: __________________________________________

(b) Taxpayer Identification Number: __________________

(c) Date of Organization or Incorporation: _____________

                                      -4-
<PAGE>

(d) Address (Post Office Boxes are not acceptable):

         ----------------------------------------------------

         ----------------------------------------------------

(e) Telephone Number: (____) ________________

(f) State or other Jurisdiction
         in which Organized: ____________________

         The information requested in items 3 and 4 above should also be
provided with regard to each trustee, custodian or other fiduciary who is making
the investment decision on behalf of the investor. Separate sheets should be
used if necessary.

5.  Investor -- if a Pension or Profit Sharing Plan, SEP or IRA

Name of Investor:__________________________________________

----------------------------------------------------

(a) Type of Plan or Other Entity: ______________________________

(b) Taxpayer Identification Number: __________________

(c) Date of Organization or Formation: ________________

(d) Address (Post Office Boxes are not acceptable):

         ----------------------------------------------------

         ----------------------------------------------------

(e) Telephone Number: (____) ____________________

(f) State or other Jurisdiction
         in which Organized: ________________________

(g) Was this plan or other entity formed for the specific purpose of investing
in the Company?   Yes _______ No ________

B.  Suitability Standards for Investors
    -----------------------------------

         The Company intends to rely upon the exemption from registration
afforded by Rules 501-503 and Rule 506 of Regulation D under the Act. Therefore,
representations and information as to the qualification of the undersigned under
Regulation D, as set forth below, are to be made and provided by the undersigned
in order for the Company better to determine

                                      -5-
<PAGE>

whether the undersigned's subscription for Shares may be accepted by the Company
in light of the requirements of Section 4(2) under the Act.

         Under Rules 501-503 and Rule 506 under the Act, Shares may be sold to
no more than 35 purchasers. For purposes of determining the Number of purchasers
of shares, persons who are Accredited Investors (as defined in Rule 501) are not
counted.
         With respect to a partnership, corporation or trust (herein called an
"Entity"), an Accredited Investor includes (i) a trust with total assets in
excess of $5,000,000 whose purchase is directed by a sophisticated person (as
described in Rule 506) and (ii) any Entity in which each of the equity owners
either (a) is an individual whose net worth (either individually or jointly with
his spouse) exceeds $1,000,000 or (b) is an individual who had an individual
income (not joint with his spouse, and computed as described below) in each of
the two most recent years in excess of $200,000, or a joint income (together
with the income of his/her spouse) in such years in excess of $300,000 and
reasonably expects such an individual or joint income in excess of such level in
the current year. Accredited Investors also include certain institutional
investors, private business development companies and tax-exempt organizations.

         Investors who would be Accredited Investors if the Company were to rely
on the exemption from registration afforded by Regulation D, and investors who
would not be Accredited Investors, each must meet certain minimum suitability
standards.

         Any investor that is able to qualify as an accredited investor is
requested to indicate the basis for such qualification under item 1 below.

1.  Accredited Investor Suitability Standards.

         For purposes of determining whether an investor is an Accredited
Investor, please check the applicable box below:

         [ ] (a) the undersigned, if a natural person, or each partner,
shareholder or beneficiary of the undersigned (a) has a net worth, individually
or jointly with his spouse, and exclusive of the value of home, home furnishings
and automobiles, of at least $1,000,000 or (b) had an individual income (not
including the income of his spouse) in excess of $200,000 or a joint income,
together with the income of his spouse, in excess of $300,000, in each of the
two most recent years and reasonably expects such individual or joint income to
reach such income level in the current, year ("income" meaning an individual's
adjusted gross income as reported on his federal income tax return, increased by
any deductions for long-term capital gains or depletion, any tax-exempt interest
and allocable losses of any partnerships of which the individual is a partner);
or

         [ ] (b) the undersigned is a domestic bank, whether acting in its
individual or fiduciary capacity; a domestic insurance company; a registered
broker or dealer, an investment company registered under the Investment Company
Act of 1940 (the "1940 Act") or "business development company" as defined in the
1940 Act; a Small Business Investment Company licensed by the United States
Small Business Administration under section 301(c) or (d) of the Small Business
Investment Act of 1958; a plan established and maintained by a state, its
political subdivision, or any agency or instrumentality of a state or its
political subdivisions, for the

                                      -6-
<PAGE>

benefit of its employees, if such plan has total assets in excess of $5,000,000:
or an employee benefit plan within the meaning of Title I of the Employee
Retirement Income Security Act of 1974, if the investment decision is made by a
plan fiduciary that is either a bank, savings and loan association, insurance
company or registered investment adviser, or if the employee benefit plan has
total assets in excess of $5,000,000; or

         [  ]  (c) the undersigned is a "private business development company"
as defined in the 1940 Act; or

         [ ] (d) the undersigned is an organization described in Section
501(c)(3) of the Internal Revenue Code of 1986, as amended, corporation,
Massachusetts or similar business trust, or partnership not formed for the
specific purpose of acquiring the securities offered, with total assets in
excess of $5,000,000; or

         [ ] (e) the undersigned is a trust, not formed for the purpose of
acquiring the Shares, whose purchase is directed by a person with such knowledge
and experience in financial and business matters that he is capable of
evaluating the merits and risks of the investment, and such trust has total
assets in excess of $5,000,000; or

         [  ]  (f) the undersigned does not meet the standards set forth above.

2.  Minimum Suitability Standards for All Investors

         (a) The undersigned, if an individual, (i) is a citizen of the United
States and at least 21 years of age (unless otherwise set forth in Paragraph
(A)(l)(c) above) and (ii) is a bona fide resident and domiciliary (not a
temporary or transient resident) of the State set forth in Paragraph (A)(l)(d)
above and has no present intention of becoming a resident of any other state or
jurisdiction. The undersigned, if a partnership, corporation, trust or other
entity, was created or organized under the laws of the jurisdiction set forth in
Paragraph (A)(2)(f) above and has no present intention of altering the
jurisdiction of its creation or Organization;

         (b) the undersigned has adequate means for providing for current needs
and personal contingencies and has no need for liquidity in this investment; and

                                      -7-
<PAGE>

         (c) the undersigned, alone or with his Purchaser Representative, has
sufficient knowledge and experience in financial and business matters so as to
be capable of evaluating the merits and risks associated with an investment in
the Company and of making an informed investment decision.

Dated: _______________

                                        ------------------------------
                                        (If Investor is an
                                        individual, signature)

                                        [------------------------------]
                                        (Printed name of Investor)

                                        By:____________________________
                                           (If Investor is an entity, signature
                                            and title of partner, trustee, or
                                            authorized officer)

                                      -8-
<PAGE>

DO NOT SIGN WITHOUT READING THIS AGREEMENT IN ITS ENTIRETY
----------------------------------------------------------

Purchaser:  ________________________

Purchaser Representative:  ____________

                             SUBSCRIPTION AGREEMENT
                             ----------------------

         THE SECURITIES REPRESENTED BY THIS INSTRUMENT HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES ACT OF ANY
STATE. THE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE SOLD OR
TRANSFERRED FOR VALUE IN THE ABSENCE OF AN EFFECTIVE REGISTRATION OF THEM UNDER
THE SECURITIES ACT OF 1933, AS AMENDED, AND/OR APPLICABLE STATE SECURITIES ACTS
OR AN OPINION OF COUNSEL TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED
UNDER SUCH ACT OR ACTS.

         THIS INVESTMENT MAY BE SUBJECT TO ADDITIONAL STATE REQUIREMENTS AS SET
FORTH BELOW.  INVESTORS SHOULD REFER TO THOSE REQUIREMENTS BEFORE EXECUTING THIS
AGREEMENT.

----------------------------
----------------------------
----------------------------
----------------------------
----------------------------

Ladies and Gentlemen:

         The undersigned has received and read the Private Placement Memorandum
dated October 13, 2000, as the same has been amended or supplemented (the
"Memorandum"), which offers to the undersigned subscriptions for shares of
Common Stock in SafeScience, Inc., a corporation formed under the laws of the
State of Nevada (the "Company"). Terms used and not defined herein have the same
meaning as those in the Memorandum.

         1. Subscription. The undersigned hereby irrevocably subscribes for and
agrees to purchase ______________ shares of Common Stock (the "Shares") for an
aggregate subscription price of $______________ (at a price per share of
$________). The undersigned shall also receive (a) a warrant to purchase
___________ shares of Common Stock of the Company in substantially the form of
Exhibit A (10% warrant coverage), (b) a warrant to purchase ______________
shares of Common Stock of the Company in substantially the form of Exhibit B
(10% warrant coverage), (c) a warrant to purchase ______________ shares of
Common Stock of the Company in substantially the form of Exhibit C (10% warrant
coverage), (d) a warrant to purchase _____________ shares of Common Stock of the
Company in substantially the form of Exhibit D (10% warrant coverage), and (e) a
warrant to purchase ______________ shares of Common Stock of the Company in
substantially the form of Exhibit E (bonus warrant, with an exercise price of
$_________ per share) hereto (all such warrants collectively, the "Warrants"),
in

                                      -9-
<PAGE>

accordance with the terms and conditions of this Subscription Agreement and
the Memorandum.

         2. Acceptance of Subscription. The undersigned acknowledges that the
Company has the right, without liability, to reject this subscription and to
determine the date of acceptance of this subscription, and that such
subscription shall be deemed to be accepted only when signed by the Company. The
undersigned agrees that subscriptions need not be accepted in the order in which
they are received.

         3. Payment. Payment in full of the subscription price is due upon the
acceptance of this subscription and shall be made by check made payable to the
order of "SafeScience, Inc." or by wire transfer to _________; ABA Routing #
____________; Account # ___________; Account Name: ____________. The Company may
deposit, at its option, the proceeds from the Subscription into an account
established by the Company pending the earlier of acceptance or rejection of
such subscription or termination of the offering.

         4. Acceptance of Subscription. Upon acceptance of this subscription by
the Company, compliance with any requirements under the Nevada corporation law,
and any other applicable law, and the designation of the undersigned as a
stockholder on the records of the Company, the undersigned shall become a
stockholder of the Company.

         5.  [Intentionally left blank.]

         6.  Representations and Warranties of Undersigned.  The undersigned
hereby represents and warrants to the Company that:

         (a) the undersigned, if an individual, is not less than twenty-one
years of age;

         (b) the undersigned, either alone or with his Purchaser Representative,
if any, named below has such knowledge and experience in financial and business
matters that he is capable of evaluating the merits and risks of an investment
in the Company, and, if a resident of a certain state, meets any additional
suitability standards applicable to him under state law;

         (c) if the undersigned is utilizing a Purchaser Representative for this
investment:

                  (i) such Purchaser Representative, named at the beginning of
         this Agreement, has acted as his "Purchaser Representative" as defined
         in Regulation D under the Securities Act of 1933, as amended;

                  (ii) the undersigned has relied upon the advice of such
         Purchaser Representative as to the merits of an investment in the
         Company and the suitability of such investment for the undersigned; and

                  (iii) such Purchaser Representative has heretofore confirmed
         to the undersigned in writing (a true and correct copy of which is
         furnished to the Company herewith) during the course of this
         transaction any past, present or future

                                      -10-
<PAGE>

         material relationship, actual or contemplated, between the Purchaser
         Representative and/or its affiliates and the Company and/or any of its
         affiliates, and any compensation received or to be received as a result
         thereof;

         (d) if the undersigned is a partnership, corporation, trust or other
entity:

                  (i) it was not formed for the purpose of this investment;

                  (ii) it is authorized and otherwise duly qualified to purchase
         and hold Shares; and

                  (iii) this Subscription Agreement has been duly and validly
         authorized and executed and, when delivered, will constitute the legal,
         valid, binding and enforceable obligation of the undersigned;

         (e) if the undersigned prospective investor is subject to the Employee
Retirement Income Security Act of 1974, as amended ("ERISA"), to the best of the
undersigned's knowledge, neither the Company nor any affiliate of the Company is
a party in interest or disqualified person, as defined in ERISA Section 3(14)
and the Internal Revenue Code of 1954, as amended, section 4975(e)(2),
respectively, with respect to such plan;

         (f) the undersigned is not subject to a statutory disqualification, as
set forth in Section 3(a)(39) of the Securities Exchange Act of 1934, as
amended;

         (g) the undersigned and his Purchaser Representative, if any, have been
given full and complete access to all information with respect to the Company
and the Company's proposed activities that the undersigned and his Purchaser
Representative, if any, have deemed necessary to evaluate the merits and risks
of an investment in the Company;

         (h) the undersigned and, if applicable, his Purchaser Representative,
have had a full opportunity to ask questions of and to receive satisfactory
answers from a representative of the Company concerning the terms and conditions
of this investment and all such questions have been answered to the full
satisfaction of the undersigned;

         (i) the undersigned and, if applicable, his Purchaser Representative,
have received and read carefully a copy of the Memorandum, including the
exhibits thereto, and the undersigned is familiar with and agrees to all the
terms and conditions of the offering of Shares and the Warrants set forth in the
Memorandum;

         (j) the undersigned is aware of the risks associated with an investment
in the Company, including those described in the "Risk Factors" section of the
Memorandum;

         (k) the undersigned has adequate means of providing for his current
needs and possible personal contingencies, has no need for liquidity with
respect to his investment in the Company, and has financial resources sufficient
to bear the economic risk of such investment;

                                      -11-
<PAGE>

         (l) the undersigned has been advised and understands that an investment
in the Company is highly speculative and has received no representations or
warranties from the Company with respect to such investment other than those
contained in the Memorandum;

         (m) the undersigned acknowledges that there are substantial
restrictions on the transferability of, and there will be no public market for,
the Shares and the shares of Common Stock issuable upon exercise of the Warrants
(the "Warrant Shares") and, accordingly, it may not be possible for the
undersigned to liquidate his investment in case of an emergency or otherwise,
and the undersigned has been advised that while Rule 144 of the Securities Act
of 1933, as amended, is presently applicable to Shares and the Warrant Shares,
the undersigned understands that the Company may not continue to be obligated to
make publicly available any information, filings and reports which are a
condition to the availability of Rule 144;

         (n) the undersigned is aware that no securities administrator of any
state or federal government has made or will make any finding or determination
relating to this investment;

         (o) Shares and the Warrants subscribed for hereby are being purchased
for the undersigned's own account (or a trust account if the undersigned is a
trustee), for investment purposes only and are not being purchased with a view
to or for any resale, fractionalization, subdivision or distribution of such
Shares; and

         (p) all information which the undersigned and his Purchaser
Representative, if any, has provided to the Company, including (but not limited
to) the information, representations and warranties of the undersigned contained
in the Purchaser Suitability Statement executed by the undersigned and submitted
to the Company in connection with this Subscription, is true and correct in all
material respects as of the date set forth below and the undersigned agrees to
furnish any additional information which the Company may request so as to
determine the suitability of the undersigned, and to notify the Company
immediately should any material changes in such information occur.

         7. Compliance with Federal and State Securities Laws. The undersigned
understands and agrees that the following restrictions and limitations are
applicable to his purchase, resales, pledges, hypothecations or other transfers
of Shares and the Warrant Shares:

         (a) The undersigned agrees that Shares and the Warrant Shares shall not
be sold, pledged, hypothecated or otherwise transferred unless such Shares or
Warrant Shares are registered under the Securities Act of 1933, as amended, and
applicable state securities laws or are exempt therefrom.

         (b) A legend in substantially the following form has been or will be
placed on any instruments evidencing Shares and the Warrant Shares:

         THE SECURITIES REPRESENTED BY THIS INSTRUMENT HAVE NOT BEEN REGISTERED
         UNDER THE SECURITIES ACT OF 1933, AS

                                      -12-
<PAGE>

         AMENDED, OR THE SECURITIES ACT OF ANY STATE. THE SECURITIES HAVE BEEN
         ACQUIRED FOR INVESTMENT PURPOSES, AND SUCH SECURITIES MAY NOT BE SOLD
         OR TRANSFERRED FOR VALUE IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
         OF THEM UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND/OR
         APPLICABLE STATE SECURITIES ACTS OR AN OPINION OF COUNSEL SATISFACTORY
         TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER SUCH ACT
         OR ACTS.

         (c) If applicable, the legend described in subparagraph (b) above will
be placed with respect to any new instrument(s) or other document(s) issued upon
presentment by the undersigned of such instrument(s) or other document(s) for
transfer.

         8. Transferability. The undersigned understands and agrees that the
restrictions on the transfer or assignment of Shares and the Warrant Shares
which may be imposed by the states in which such Shares and Warrant Shares may
be offered shall be binding on the undersigned.

         9.  Registration Rights.

         (a) The Company shall file a registration statement covering the Shares
and the shares of common stock issuable upon exercise of the Warrants within 60
days of the earlier to occur of (a) the Company's termination of the offering
under the Memorandum (the "Final Closing") and (b) December 31, 2000.
Thereafter, the Company shall use its best efforts to cause such registration
statement to be declared effective by the 120th day after the earlier of (a) the
Final Closing and (b) December 31, 2000.

         (b) The Company may postpone the filing of any registration statement
required pursuant to this Section 9 for a reasonable period of time, not to
exceed sixty (60) days in the aggregate, and not more than once in any ninety
(90) day period, if the Company has been advised by legal counsel in writing,
with a copy to the undersigned upon their request, that such filing would
require a special audit or the disclosure of a material impending transaction or
other matter and the Board of Directors of the Company determines reasonably and
in good faith that such disclosure would have a material adverse effect on the
Company.

         (c) The Company shall pay all expenses incurred by the Company in
connection with the registration, qualification and/or exemption of the Shares,
including any SEC and state securities law registration and filing fees,
printing expenses, fees and disbursements of the Company's counsel and
accountants, transfer agents' and registrars' fees, fees and disbursements of
experts used by the Company in connection with such registration, qualification
and/or exemption, and expenses incidental to any amendment or supplement to the
registration statement or prospectuses contained therein. The Company shall not,
however, be liable for any sales, broker's or underwriting commissions upon sale
by the undersigned or other holder of any of the Shares.

                                      -13-
<PAGE>

         (d) The Company shall indemnify the undersigned, as provided in the
Memorandum.

         (e) The rights granted in this Section 9 inure to the benefit of all
the undersigned's successors, heirs, pledgees, assignees, transferees and
purchasers of the Shares and Warrant Shares, as the case may be.

         10. Indemnification. The undersigned acknowledges and understands the
meaning and legal consequences of the representations and warranties herein and
hereby agrees to indemnify and hold harmless the Company and its officers,
directors, controlling persons, agents, employees, attorneys and accountants
from and against any and all loss, damage or liability, together with all costs
and expenses (including attorneys fees and disbursements) which any of them may
incur by reason of:

         (a) any breach of any representation, warranty or agreement of the
undersigned contained in this Subscription Agreement; or

         (b) any false, misleading or inaccurate information, or any breach of
any representation, warranty or agreement of the undersigned, contained in the
Purchaser Suitability Statement executed by the undersigned.

         Notwithstanding the foregoing, no representation, warranty,
acknowledgment or agreement made herein by the undersigned shall in any manner
be deemed to constitute a waiver of any rights of the undersigned under federal
or state securities laws. All representations and warranties contained in this
Subscription Agreement and the Purchaser Suitability Statement executed by the
undersigned, and the indemnification contained in this paragraph 10, shall
survive the acceptance of this subscription and any other transaction
contemplated herein.

         11. Applicable Law. This Subscription Agreement shall be governed by
and construed in accordance with the laws of the Commonwealth of Massachusetts,
except as to any matter, to the extent it involves any United States statute, in
accordance with the laws of the United States.

         12. Gender. Whenever the singular number is used herein and when
required by the context the same shall include the plural and the masculine
gender shall include the feminine and, where applicable, shall include any
corporation, firm or partnership executing this Subscription Agreement.

         13. Binding Effect. This Subscription Agreement shall be binding upon
and inure to the benefit of the undersigned and his successors and neither this
Subscription Agreement nor any interest herein shall not be assignable by him.
This Subscription Agreement shall inure to the benefit of the Company and its
successors and assigns, and upon its acceptance by the Company shall be binding
upon the Company and its successors and assigns.

                                      -14-
<PAGE>

         14. Joint and Several Representations. If more than one person is
signing this Subscription Agreement, each representation, warranty and
undertaking herein shall be the joint and several representations warranty and
undertaking of each such person. If the undersigned is a partnership,
corporation, trust or other entity, the undersigned further represents and
warrants that (a) the individual executing this Subscription Agreement has full
power and authority to execute and deliver this Subscription Agreement on behalf
of the undersigned and (b) the undersigned has full right and power to perform
its obligations pursuant to the provisions hereof and become a stockholder of
the Company.

         15. Notice. All notice required to be given to the undersigned shall be
deemed given when received by the undersigned, and shall be sent by air express
courier with regular service to the undersigned at the address indicated below,
or as amended by written notice to the Company.

         IN WITNESS WHEREOF, the undersigned has executed and sealed this
Subscription Agreement this day of __________________2001.

                                          [----------------------------]
                                          (Print or type name of
                                          Subscriber)

                                          ------------------------------
                                          (If Subscriber is an
                                          individual, signature)

                                          By:___________________________
                                                (If Subscriber is an entity,
                                                 signature and title of partner,
                                                 trustee, or authorized officer)

                                          [----------------------------]
                                          (If Purchaser is an individual,
                                          home address; or if Purchaser
                                          is an entity, business address)

                                          ------------------------------
                                          (Social Security or Tax
                                           Identification Number)

                                          ------------------------------
                                          (Signature of Joint Tenant, if any)

                                          ------------------------------
                                          (Printed Name of Joint Tenant, if any)

                                      -15-
<PAGE>

                                          ------------------------------

                                          ------------------------------
                                          City, State and Zip Code
                                          (Home Address)

                                          ------------------------------
                                          (Social Security or Tax
                                           Identification Number of
                                           Joint Tenant)

                                          ------------------------------
                                          (Social Security or Tax
                                           Identification Number of
                                           Joint Tenant)

                                          Type of Ownership
                                          (check as
                                          appropriate):

                                          ___ Individual

                                          ___ Joint tenants with
                                                   rights of survivorship

                                          ___ Tenants in common

                                          ___ Community property

                                          ___ Trust

                                          ___ Other (indicate):

                                          Corporation

         Total Dollar Amount of Subscription: ____________________.

         THIS INVESTMENT MAY BE SUBJECT TO ADDITIONAL STATE REQUIREMENTS AS SET
FORTH BELOW. INVESTORS SHOULD REFER TO THOSE REQUIREMENTS BEFORE EXECUTING THIS
AGREEMENT.

                                      -16-
<PAGE>

         Subject to the terms and conditions of this Subscription Agreement, the
foregoing subscription is approved and accepted as of the _____ day of
____________, 2001.

                                             SAFESCIENCE, INC.

                                             By:______________________________
                                                   Bradley J. Carver, President

                                      -17-<PAGE>

                                                                   Exhibit 10.15

                ________________________________________________
                ________________________________________________

                                  RHODIA INC.

                                   Sublessor

                                       TO

                              INSMED INCORPORATED

                                   Subtenant

                          ____________________________

                                    SUBLEASE
                          ____________________________

                           Dated: March 30, 2001

                                   Property:

                             4851 Lake Brook Drive,
                          Innsbrook Corporate Center,
                            Henrico County, Virginia

                ________________________________________________
                ________________________________________________
<PAGE>

                                TABLE OF CONTENTS
                                -----------------

<TABLE>
<CAPTION>
                                                                 Page
                                                                 ----
<S>                                                              <C>
 1.  PREMISES................................................     1

 2.  TERM....................................................     3

 3.  RENT....................................................     4

 4.  SECURITY................................................     6

 5.  CONDITION OF PREMISES...................................     6

 6.  USE.....................................................     7

 7.  REPAIRS AND MAINTENANCE.................................     7

 8.  ALTERATIONS.............................................     8

 9.  ASSIGNMENT AND SUBLETTING...............................     8

10.  ACCESS TO PREMISES......................................     8

11.  INDEMNITY...............................................     9

12.  INSURANCE...............................................     10

13.  SUBORDINATE TO PRIME LEASE..............................     11

14.  TERMINATION OF PRIME LEASE..............................     11

15.  NOTICES.................................................     12

16.  DEFAULT.................................................     13

17.  WAIVER OF JURY TRIAL AND RIGHT TO COUNTERCLAIM..........     15

18.  END OF TERM.............................................     15

19.  HOLDOVER................................................     15

20.  BROKERAGE...............................................     16
</TABLE>

                                       i
<PAGE>

<TABLE>
<S>                                                               <C>
21.  FINANCIAL STATEMENTS AND ESTOPPEL CERTIFICATES..........     16

22.  HAZARDOUS SUBSTANCES....................................     17

23.  MISCELLANEOUS COVENANTS.................................     18
</TABLE>

EXHIBITS TO SUBLEASE

EXHIBIT A   -  Plan of Showing Location of Premises
EXHIBIT A-1 -  Plat Showing Reserved Parking Spaces
EXHIBIT B   -  Furniture
EXHIBIT C   -  Construction Plans

SCHEDULE 1  -  Energy Distribution Model

                                      ii
<PAGE>

                                   SUBLEASE
                                   --------

     THIS SUBLEASE, dated the ____ day of March 2001, between RHODIA INC., a
Delaware corporation, having an office at CN 7500, Cranbury, New Jersey, 08512-
7500 ("Sublessor") and INSMED INCORPORATED, a Virginia corporation, having an
       ---------
office at 800 East Leigh Street, Suite 206, Richmond, Virginia 23219
("Subtenant").
  ---------

                                   RECITALS
                                   --------

1.   Albright & Wilson Americas Inc., a Delaware corporation ("Albright") and GP
Henrico, L.L.C., a Rhode Island limited liability company ("Landlord") entered
into that certain Building Lease dated October 10, 1995, as amended by that
certain First Amendment to Lease dated September 6, 1996 (the "Prime Lease")
pursuant to which Albright leased from Landlord certain property identified in
the Prime Lease (the "Prime Lease Premises").

2.   Sublessor is the surviving entity of its merger with Albright, and is the
current tenant under the Prime Lease.

3.   Sublessor is willing to sublease to Subtenant, and Subtenant desires to
sublease from Sublessor, a portion of the Prime Lease Premises upon the terms
and conditions set forth in this Sublease.

                                   AGREEMENT
                                   ---------

1.   PREMISES.

     A.   Space.  Sublessor hereby subleases to Subtenant, and Subtenant hereby
          -----
subleases from Sublessor, those certain premises ("Premises") shown on Exhibit A
                                                   --------            ---------
attached hereto and made a part hereof, consisting of approximately 24,000
rentable square feet of ground floor office space (the "Office Space") and
approximately 22,000 square feet of ground floor laboratory space (the
"Laboratory Space") in the building located at 4851 Lake Brook Drive, Innsbrook
Corporate Center, Henrico County, Virginia (the "Building"), together with, a)
                                                 --------
on a non-exclusive basis, all easements, rights, privileges, and interests
appurtenant thereto provided for under the Prime Lease, including four (4) per
one thousand (1,000) parking spaces in the lot adjacent to the Building and, b)
on an exclusive basis, ten (10) reserved parking spaces close to the entrance to
the Building at locations shown on Exhibit A-1 attached hereto.

     B.   Roof Top.  Subtenant shall have the right, subject to the consent of
          --------
Sublessor, Landlord, the Innsbrook Owner's Association and all applicable laws,
rules, regulations and ordinances, to use a small portion of the roof for
telecommunication equipment, including an antenna and microwave transmitting or
receiving equipment. Such equipment shall be installed at Subtenant's own
expense and Subtenant shall immediately repair and shall indemnify Sublessor for
any and all damage to the Building caused by the installation or removal of such
equipment.

                                       1
<PAGE>

     C.   Signage.   Subtenant shall be permitted to install, at its expense, an
          -------
exterior sign on the existing in-place monument sign, such sign shall comply
with all applicable laws, rules and regulations, and which shall be of such
size, design and character as Sublessor (and Landlord, if required) shall
approve.  Subtenant shall maintain any such sign in good condition and repair,
and shall remove all signs and repair all damage caused by the installation or
removal thereof, at the expiration or termination of the Term.  Other than such
permitted sign(s), Subtenant shall not place or install, or permit or suffer to
be placed or installed, or maintain, any sign outside of the Premises.

     D.   Furniture and Phone System.  Sublessor shall provide Subtenant with
          --------------------------
the exclusive use of the furniture listed on Exhibit B attached hereto and made
                                             ---------
a part hereof (the "Furniture") for the Term. Subtenant shall also have the
right to use Sublessor's phone and voice mail system currently installed on the
Premises (the "Phone System") for the Term. Any cost or expense to modify or
alter the Phone System shall be borne by Subtenant. At the end of the Initial
Term, Subtenant shall have the option to purchase the Furniture and the Phone
System for the sum of One Dollar ($1.00) each. Subtenant hereby acknowledges
that Sublessor intends to relocate its fume hood from the Premises to its
facility in Charleston, South Carolina, and such fume hood shall not be part of
the Premises.

     E.   Subtenant Improvement Allowance.  Sublessor shall give to Subtenant a
          -------------------------------
one time tenant improvement allowance of $4.50 per rentable square foot (the
"Subtenant Improvement Allowance") for Subtenant's use to cover any and all
costs related to Subtenant's construction of a board room, executive office and
other interior improvements on the Premises and for Subtenant's costs related to
signage for the Premises as set forth in Section 1C above. Subtenant shall
submit plans for such construction to Sublessor for approval by Sublessor and
Landlord. Subtenant shall be responsible for obtaining any and all required
permits and approvals for such construction, and shall ensure that such
construction complies with all applicable Laws (as defined in Section 6). Any
portion of the Subtenant Allowance not used for such construction or signage may
be used to purchase furniture, fixtures or equipment. Subtenant shall have
access to the Premises thirty (30) days prior to the Commencement Date (as
defined below) for purposes of completing such construction. Subtenant shall
protect, indemnify, defend and hold Sublessor harmless from any and all loss,
liability, damage, costs, expense or claims (including, without limitation,
attorneys' fees), arising from or as a result of Subtenant's (or its agents',
invitees', employees' or contractors') occupancy or construction activity on the
Premises, unless otherwise caused by the negligence or willful misconduct of
Sublessor, Landlord or their agents, employees or assigns.

     F.   Sublessor's Improvements.  Sublessor shall cause the lobby of the
          ------------------------
Premises to be renovated in accordance with Scheme A developed by HKS, Inc. and
approved by Sublessor, Landlord and Subtenant and as shown more particularly on
Exhibit C attached hereto and made a part hereof. Sublessor shall pay for any
---------
and all cost associated with the lobby renovation to, a) demolish existing wall
or structures in the Subtenant's new reception area, b) relocate or replace the
existing marble back-drop structure (including removal of two levels of such
back-drop), c) repair the carpet in the effected areas, and d) repaint any new
drywall in the Premises all pursuant

                                       2
<PAGE>

to Scheme A and as required by applicable Laws. Any additional costs shall be
borne exclusively by Subtenant.

     G.   Right of First Refusal. In the event that the second floor of the
          ----------------------
Building (the "Second Floor") becomes vacant and Sublessor receives a bona fide
offer from an independent third party prospective subtenant to sublease the
Second Floor, and provided either (i) Subtenant is not in default under this
Sublease (and no events have occurred which, with notice, or the passage of
time, or both, would become an event of default hereunder), or (ii) Subtenant
has cured all defaults under this Sublease within five (5) days following
receipt of a notice referred to below, Sublessor shall deliver to Subtenant a
written notice of such offer. Subtenant shall have five (5) business days from
receipt of such notice to exercise its right to sublease the Second Floor upon
the same terms and conditions set forth in this Sublease. Such option shall be
exercisable by written notice to the Sublessor within such five (5) business day
period, and the execution and delivery of a mutually agreeable sublease in the
form of this Sublease within thirty (30) days thereafter. A failure by the
Subtenant to give written notice to the Sublessor within such five (5) business
day period or the failure to timely execute and deliver the sublease shall be
deemed a rejection by the Subtenant of its option to sublease the Second Floor.
Thereafter, the Sublessor shall have the right to sublease the Second Floor to
such third party prospective tenant pursuant to the terms and conditions agreed
upon by Sublessor and such prospective tenant. In the event Sublessor does not
sublease to such third party, Sublessor shall provide notice of any new bona
fide third party offer to Subtenant pursuant to the terms of this Section 1G and
Subtenant shall retain its right of first refusal pursuant to the notice and
election requirements set forth herein. Notwithstanding the foregoing, Sublessor
shall not be required to provide notice of any new bona fide third party offer
to Subtenant if Sublessor receives such new offer within four (4) months after
the date on which Subtenant failed to deliver its notice to exercise Subtenant's
right of first refusal as provided above.

2.   TERM.
     ----

     A.   Initial Term. The initial term of this Sublease ("Initial Term") shall
          ------------                                      ------------
be the period of sixty two (62) months commencing on the later of (i) September
1, 2001, (ii) sixty (60) days from the date that the Premises are released to
Subtenant for its up-fit of the space, (iii) substantial completion of the lobby
by the Sublessor pursuant to Section 1F above, and (iv) receipt of a
decontamination report from a qualified environmental engineering company
("Commencement Date"), and ending on the later of (x) October 31, 2006, and (y)
  -----------------
the last day of the month occurring sixty-two (62) months after the Commencement
Date  ("Expiration Date"), unless sooner terminated as herein provided.  The
        ---------------
"Rent Commencement Date" shall be the first day of the month occurring not less
 ----------------------
than sixty days after the Commencement Date.  Notwithstanding the foregoing, if
Sublessor has not (a) fulfilled its duties under clauses (iii) or (iv) above, or
(b) released the Premises to the Subtenant, by October 1, 2001, Subtenant shall
have the right to terminate this Sublease by giving written notice to Sublessor
and neither party shall have any further obligations hereunder.  Subtenant shall
have the right to enter the Office Space, for the sole purpose of completing its
upfit of the Office Space, at any time after April 1, 2001, provided that (i)
Sublessor shall have approved Subtenant's construction plans and (ii) the
provisions of Section 11 shall be in full force and effect during any such
              ----------
period.

                                       3
<PAGE>

     B.   Early Occupancy.  Notwithstanding the foregoing, Subtenant shall have
          ---------------
the right to occupy the Office Space on July 1, 2001.  In the event Subtenant
chooses to occupy the Office Space at any time on or after July 1, 2001 and
before the Commencement Date, the rent commencement date for the Office Space
("Office Rent Commencement Date") shall be the first day of the month occurring
not less than sixty (60) days after Subtenant's occupancy of the Office Space at
a rate of $12.25 per square foot.

     C.   Renewal Options.  Provided the Subtenant is not in default under this
          ---------------
Sublease beyond any applicable cure period, Subtenant shall have the right to
extend the Initial Term until September 30, 2011.  Subtenant shall exercise its
right by giving notice to Sublessor in writing at least nine (9) months before
the end of the Initial Term.  With the exception of the provisions of this
Section 2C, the terms and conditions during any extended term shall be the same
as those in effect during the Initial Term of this Sublease.  The "Term" shall
                                                                   ----
include the Initial Term and any extended term.

3.   RENT.
     ----

     A.   Base Rent.  Commencing on the Rent Commencement Date, Subtenant shall
          ---------
     pay to Sublessor rent ("Base Rent") for the Premises in the amount of
                             ---------
     $15.25 per square foot.  Each monthly installment of Base Rent shall be
     payable in advance on the first day of each month during the Term.  The
     Base Rent shall increase at a rate of 1.75% per year of the Term on the
     anniversary of the Commencement Date.  Notwithstanding, the foregoing,
     Subtenant shall commence payment of its Pro Rata Share of the operating
     expenses listed in Sections 3D, 3E and 3F immediately upon occupancy of the
     Premises.

     B.   Payments.  Base Rent and all other amounts payable by Subtenant to
          --------
     Sublessor under this Sublease ("Additional Rent ") shall be paid when due,
                                     ----------------
     without notice or demand, and, except as otherwise provided herein, without
     deduction, abatement, counterclaim or setoff, at the address of Sublessor
     set forth in Section 15 or to such other person and/or at such other
                  ----------
     address as Sublessor may from time to time designate by notice to
     Subtenant.  No payment by Subtenant of any amount less than the amount
     stipulated to be paid hereunder shall be deemed other than on account of
     the earliest stipulated Base Rent or Additional Rent; nor shall any
     endorsement or statement on any check or letter be deemed an accord and
     satisfaction, and Sublessor may accept any check or payment without
     prejudice to Sublessor's right to recover the balance due or to pursue any
     other remedy available to Sublessor.

     C.   Subtenant's Pro Rata Share.  Subtenant shall pay its pro rata share of
          --------------------------
     all operating expenses, taxes and insurance for the Prime Lease Premises.
     For purposes of this Section 3, "Subtenant's Pro Rata Share" shall be 50%
                          ---------   --------------------------
     of the expenses for the Office Space, 65.7% of the expenses for the common
     areas, and 100% of the expenses for the Laboratory Space.

                                       4
<PAGE>

     D.   Taxes.  Beginning on the Commencement Date, Subtenant shall pay to
          -----
Sublessor, as Additional Rent, Subtenant's Pro Rata Share of all real estate
taxes, assessments, levies and other charges, general or special, foreseen or
unforeseen (the "Taxes") imposed or assessed against the Building or the land
                 -----
upon which it is situated (the "Land") under the current or any future taxation
                                ----
or assessment system or modification of, supplement or substitute for such
system, but only to the extent such Taxes relate to periods covered by the term
of this Sublease.  "Taxes" shall also include any costs, including reasonable
                    -----
attorneys' fees, incurred by Sublessor to appeal, contest or reduce Taxes, but
only to the extent Subtenant consents to such proceedings, which consent shall
not be unreasonably withheld.

     E.   Operating Expenses and CAM Charges.  Beginning on the Commencement
          ----------------------------------
Date, and pursuant to this Subsection and Section 7, Subtenant shall pay to
                                          ---------
Sublessor, as Additional Rent, Subtenant's Pro Rata Share of the costs for the
operation, maintenance, fire monitoring, security and repair of the Prime Lease
Premises, including a management fee of Three Percent (3%) of Base Rent (the
"Management Fee") (collectively, the "Operating Expenses"), including without
                                      ------------------
limitation, costs of maintaining, repairing, operating and providing utilities
and liability insurance for the Premises and the common areas ("CAM Charges");
                                                                -----------
costs of compliance with Laws (as defined in Section 6); costs of repair,
                                             ---------
maintenance and replacement of the roof, mechanical systems, landscaping,
sidewalks, parking areas, and structural elements of the Building.  The costs of
any replacement of the roof, mechanical systems, sidewalks, parking areas or
structural elements of the Building shall be amortized over the useful life of
the replaced item.  Subtenant shall not be required to pay its Pro Rata Share of
the cost of any major replacement during the first twelve (12) months of this
Sublease, but shall commence paying its Pro Rata Share of such replacement, as
amortized over the useful life of the item, after the twelfth month.  Sublessor
shall meter the utilities for the Premises as set forth on Schedule 1, attached
hereto and made a part hereof.  Subtenant shall pay for its usage of such
utilities as set forth in Schedule 1.  Except for interruptions caused by
Sublessor's negligence or willful misconduct, Sublessor shall not be responsible
for any failure or interruption, for any reason whatsoever, of any of the
services or utilities supplied to the Premises, and the same shall not result in
any abatement, diminution or reduction of rent, or constructive eviction, or
liability on the part of Sublessor.  Notwithstanding the foregoing to the
contrary, if Subtenant is prevented from using and occupying the Premises for
more than three (3) consecutive business days because of an interruption in such
services or utilities through no fault of Subtenant, Base Rent and Additional
Rent hereunder shall abate until such services or utilities are fully restored
allowing Subtenant to use and occupy the Premises.

     F.   Property Insurance.  Beginning on the Commencement Date, Subtenant
          ------------------
shall pay to Sublessor, as Additional Rent, on the first day of each month
during the Term, Subtenant's Pro Rata Share of the cost of property insurance
covering the improvements on the Prime Lease Premises, excluding insurance costs
for personal property of Sublessor, Landlord or other tenants (the "Insurance
                                                                    ---------
Costs").
-----

     G.   Adjustment to Charges for Operating Expenses and Taxes.  Sublessor may
          ------------------------------------------------------
notify Subtenant from time to time setting forth an adjustment to estimated
Operating Expenses, Taxes and Insurance Costs and Subtenant's Pro Rata Share
thereof, if Sublessor determines that

                                       5
<PAGE>

payments are insufficient to meet estimated costs. Following the end of each
calendar year, Sublessor shall determine the actual Operating Expenses, Taxes
and Insurance Costs for such year. If Sublessor determines that Subtenant's Pro
Rata Share of actual Operating Expenses or Taxes exceeds the amount paid by
Subtenant, then Subtenant shall pay the difference within thirty (30) days after
Sublessor delivers to Subtenant a statement showing such costs. If Sublessor
determines that Subtenant's Pro Rata Share of actual Operating Expenses, Taxes
or Insurance Costs is less the amount paid by Subtenant, then Sublessor shall
credit such amounts to Subtenant for Operating Expenses, Taxes and Insurance
Costs next becoming due. In the event such credit is due Subtenant in the last
year of the Term, Sublessor shall reimburse such amounts to Subtenant within
thirty (30) days of discovery. Subtenant shall have the right, at its sole
expense, to have an independent audit firm audit the records of Sublessor
detailing the Operating Expenses and Taxes within sixty (60) days of the end of
any calendar year during the Term.

4.   SECURITY.
     --------

          Upon or prior to execution of this Sublease by Subtenant, Subtenant
     shall deposit with Sublessor an amount equal to one monthly installment of
     Base Rent (the "Security Deposit") as security for the payment and
                     ----------------
     performance by Subtenant of Subtenant's obligations under this Sublease.
     Sublessor shall have the right, without notice to Subtenant, and regardless
     of the exercise of any other remedy Sublessor may have by reason of a
     default, to apply all or any part of the Security Deposit to cure any
     default of Subtenant, and, if Sublessor does so, Subtenant shall upon
     demand deposit with Sublessor the amount applied so that Sublessor shall
     have the full amount of the Security Deposit at all times during the Term.
     If Subtenant fails to make such deposit, Sublessor shall have the same
     remedies for such failure as Sublessor has for a default in the payment of
     Base Rent. If Subtenant defaults under this Sublease, the Security Deposit
     shall not be deemed liquidated damages and Sublessor may apply the Security
     Deposit to reduce Sublessor's damages, and such application of the Security
     Deposit shall not preclude Sublessor from recovering from Subtenant all
     additional damages incurred by Sublessor. The Security Deposit shall not
     bear interest.  If Subtenant fails to timely provide Sublessor with the
     Security Deposit, Sublessor may withhold delivery of possession of the
     Premises with delaying the Commencement Date or the Rent Commencement Date.
     Notwithstanding the foregoing, Sublessor has agreed to waive the
     requirement of the Security Deposit until such time as Subtenant may be in
     default beyond any applicable cure period (as set forth in Section 16)
     under this Sublease.  At such time, upon demand by Sublessor, Subtenant
     shall immediately deliver to Sublessor the Security Deposit, which shall be
     held in accordance with the terms of this Section.

5.   CONDITION OF PREMISES.
     ---------------------

          With the exception of the work to be performed under Sections 1E and
     1F above and subject to the other terms of this Sublease, Subtenant is
     leasing, and hereby accepts, the Premises "as is".

                                       6
<PAGE>

6.   USE.
     ---

     A.   Permitted Use.  Subtenant shall use and occupy the Premises for the
          -------------
uses allowed under the Prime Lease and for no other purpose, such uses to
include corporate headquarters and support and operating laboratory facility.

     B.   Compliance with Laws and Rules.  Sublessor represents and warrants to
          ------------------------------
Subtenant that (i) the Prime Lease is in full force and effect, (ii) no defaults
exist under the Prime Lease and (iii) to the best of Sublessor's knowledge the
Premises complies with all applicable Laws, including without limitation the
Americans with Disabilities Act and laws regulationg hazardous substances.  From
the date which Subtenant is given access to the Premises, Subtenant at its
expense shall occupy and use the Premises in compliance with all present and
future laws, statutes, ordinances, orders, rules, regulations and requirements
of all federal, state and municipal governments and any instrumentality thereof,
and regulations of the board of fire underwriters having jurisdiction over the
Premises, including without limitation the Americans with Disabilities Act and
laws regulating hazardous substances, and all amendments thereto (collectively,
"Laws"). Nothing in this Section shall require Subtenant to achieve greater
 ----
compliance than that required by current or future Laws, particularly, but not
limited to, situations where existing compliant conduct is grandfathered by
future Laws.  Subtenant shall comply with all reasonable rules and regulations
for the use of the Premises and the common areas as Landlord or Sublessor may
from time to time establish as long as Subtenant is provided advance notice and
the opportunity to object.

7.   REPAIRS AND MAINTENANCE.
     -----------------------

     A.   Repairs by Sublessor.  Sublessor, at Subtenant's expense as set forth
          --------------------
in Section 3E, shall make, or cause to be made, necessary structural repairs or
replacements to the Premises (but excluding windows and window frames, doors,
plate glass, store fronts, showcases and signs) and shall keep in good condition
and repair the HVAC, mechanical, electrical and plumbing systems, exterior
walls, foundations and roof of the Premises, and the landscaping, parking areas,
drives and sidewalks. Except for a casualty (no matter the cause) to the
Building, in which event the terms of Section 14B shall govern,  Sublessor shall
                                      -----------
not be required to make any such repairs where the same were caused or
occasioned by any act, omission or negligence of Subtenant, or its employees,
agents, customers, invitees or contractors. In making any such repairs or
replacements, Sublessor shall use materials equal in kind and quality to the
original work and shall comply with all Laws.

     B.   Repairs and Maintenance by Subtenant. Subtenant shall keep the
          ------------------------------------
Premises clean, neat, safe, sanitary, in good order, repair and condition.
Subtenant shall make any and all repairs which may be required as a result of
any act, omission or negligence of Subtenant, or its employees, agents,
customers, invitees or contractors, except for a casualty (no mater the cause)
to the Building, in which event the terms of Section 14B shall govern. In making
                                             -----------
such repairs, Subtenant shall use materials equal in kind and quality to the
original work and shall comply with all Laws.

                                       7
<PAGE>

8.   ALTERATIONS.
     -----------

          With the exception of the work to be performed according to Section 1E
     and any non-structural Alterations costing less than $10,000, Subtenant
     shall not make or cause, suffer or permit the making of any alteration,
     addition, change, replacement, or installation, whether structural or non-
     structural ("Alterations"), in or to the Premises without obtaining the
                  -----------
     prior written consent of Sublessor in each instance and the consent of
     Landlord as required under the Prime Lease.

          If any lien is filed against the Premises, the Building or the Land in
     connection with labor or materials furnished to Subtenant, or claimed to
     have been furnished to Subtenant, Subtenant at its expense shall cause such
     lien to be discharged or otherwise bonded within thirty (30) days after
     Subtenant receives notice that such lien has been filed.

          All Alterations shall become the property of Sublessor and, except as
     otherwise expressly provided in this Sublease, shall remain upon and be
     surrendered with the Premises at the expiration or earlier termination of
     the Term. Trade fixtures, equipment, furniture and other personal property
     which Subtenant installs at its own expense shall remain Subtenant's
     property and may be removed at any time during the Term, and shall be
     removed at the expiration or earlier termination of this Sublease, provided
     that Subtenant promptly repairs any damage caused by such removal.

9.   ASSIGNMENT AND SUBLETTING.
     -------------------------

          Subtenant shall have the right to sublet all or a portion of the
     Premises and assign this Sublease with the prior written consent of
     Sublessor and Landlord according to the terms of this Sublease and Section
     14 of the Prime Lease, which consent shall not be unreasonably withheld,
     conditioned or delayed.  Notwithstanding the foregoing, Subtenant shall not
     be required to obtain the consent of the Sublessor or Landlord to assign or
     sublet to a parent or subsidiary of Subtenant, provided that such
     assignment or sublease shall in no way release Subtenant from its
     obligations under this Sublease. Fifty percent (50%) of any excess rentals
     received by Subtenant under such sublease or assignment shall be paid to
     Sublessor.  Subtenant shall remain liable under this Sublease and shall in
     no way be released from any of its obligations under this Sublease.

10.  ACCESS TO PREMISES.
     ------------------

          Sublessor, upon reasonable prior notice, shall have the right to enter
     upon and in the Premises at all reasonable times to examine the same and to
     make such repairs, replacements, alterations, improvements and additions in
     the Premises and the Building (including, without limitation, the
     installation, repair, maintenance and replacement of pipes, duct work,
     conduits, utility lines and wires through the column space and partitions
     in the Premises and beneath the lower floor slabs and above the ceiling of
     the Premises) as Sublessor may deem necessary or desirable, and to take all
     materials into and upon the

                                       8
<PAGE>

     Premises that may be required therefor, without the same constituting an
     eviction of Subtenant, and without any abatement of Base Rent or Additional
     Rent; provided however, that to the extent such activities result in
     Subtenant's inability to occupy or use the Premises or any part thereof,
     then Base Rent and Additional Rent shall abate proportionally until such
     time as the Premises are restored to Subtenant. Sublessor, upon prior
     notice to Subtenant, shall also have the right to enter upon the Premises
     at reasonable times to show the Premises to prospective purchasers, lessors
     or lessees, tenants (during the last nine months of the Term) or mortgagees
     of all or any part of the Prime Lease Premises. During the last nine months
     of the Term, Sublessor may also place upon the Premises a "For Rent" sign,
     which sign shall not be removed, obliterated or hidden by Subtenant.

11.  INDEMNITY.
     ---------

     A.   Indemnifications.  Except for casualties (no matter the cause thereof)
          ----------------
which shall be governed by Section 14B, Subtenant shall protect, indemnify,
                           -----------
defend and hold Sublessor harmless from and against any and all claims, damages,
loss, liability (including without limitation liability under the Prime Lease),
cost or expense (including without limitation reasonable attorneys' fees), which
Sublessor may incur or pay out by reason of (i) any accidents, damages or
injuries to persons or property occurring in, on or about the Premises, not
otherwise caused by the acts, omissions, negligence or willful misconduct of
Sublessor or Landlord, their employees, agents, contractors, invitees or
assigns, (ii) any breach or default hereunder on Subtenant's part, (iii) any
work done in or to the Premises by Subtenant, its contractors or agents, (iv)
any liens filed against the Premises due to work being performed by or at the
direction of the Subtenants and not timely removed by Subtenant pursuant to
Section 8, or (v) any negligence or willful misconduct on the part of Subtenant,
---------
its employees, agents, contractors, invitees, or any person claiming through or
under Subtenant.   Sublessor shall protect, indemnify, defend and hold Subtenant
harmless from and against any and all claims, damages, loss, liability, cost or
expense (including without limitation reasonable attorney's fees), which
Subtenant may incur or pay out by reason of (i) any accidents, damages or
injuries to person or property occurring in, on or about the Prime Lease
Premises, excluding the Premises, not otherwise caused by the acts, omissions,
negligence or willful misconduct of Subtenant, its employees, agents,
contractors, invitees or assigns, (ii) any breach or default hereunder by
Sublessor, (iii) any work done in or to the Prime Lease Premises by Sublessor,
its agents or contractors, (iv) any negligence or willful misconduct on the part
of Sublessor, its employees, agents, contractors, invitees, or any person
claiming through or under  Sublessor, or (v) any condition of the Prime Lease
Premises existing on or prior to the date of this Sublease, including, but not
limited to, an environmental condition.

     B.   Liability of Sublessor.  All property of Subtenant and its employees,
          ----------------------
agents, contractors or invitees in or about the Premises shall be kept and
stored at Subtenant's sole risk, and Subtenant shall hold Sublessor harmless
from any claims arising out of damage to, or loss of, the same, unless caused by
Sublessor's negligence of willful misconduct.  Sublessor shall not be liable for
any interruption of or loss to Subtenant's business arising from any of the
above-described acts or causes, or for any consequential damages sustained by
Subtenant arising out of the loss of or damage to any such property.

                                       9
<PAGE>

12.  INSURANCE.
     ---------

     A.   Subtenant's Insurance.  Subtenant shall maintain throughout the Term
          ---------------------
(i) a commercial general liability insurance policy for the Premises and all
appurtenant areas and the conduct and operation of business therein, and the
acts and omissions of Subtenant, its agents, employees and contractors, naming
Sublessor, Landlord and any mortgagee of the Prime Lease Premises as additional
insured parties, as primary coverage over any insurance carried by Sublessor,
Landlord or any mortgagee, with limits of not less than $3,000,000 per
occurrence for personal or bodily injury, death and property damage, endorsed to
provide coverage for fire legal liability and contractual liability for
Subtenant's indemnity obligations under this Sublease, and water damage and
sprinkler leakage legal liability; (ii) all-risk property insurance with
endorsements for vandalism and malicious mischief, water damage and sprinkler
leakage, for the full replacement value of Subtenant's inventory, equipment,
trade fixtures and other personal property located in the Premises; (iii) rent
abatement insurance in the amount of six (6) months' Base Rent for the benefit
of Sublessor; (iv) worker's compensation insurance to the extent required by
Laws; and (v) such other insurance, in such amounts and against such risks as
Sublessor specifies in writing to Subtenant, as may be reasonably required by
the holder of any mortgage on the Prime Lease Premises and which is customarily
and commonly insured against by prudent owners or tenants of property similar to
the Prime Lease Premises.

          B.  Subtenant shall deliver to Sublessor a fully paid for policy or
     certificate prior to taking possession of the Premises to evidence that
     Subtenant has obtained the insurance required by this Section 12.  If
                                                           ----------
     Subtenant fails to provide Sublessor with such evidence, Sublessor may
     withhold delivery of possession of the Premises without delaying the
     Commencement Date or the Rent Commencement Date.  Subtenant shall procure
     and pay for renewals of such insurance from time to time before the
     expiration thereof, and Subtenant shall deliver to Sublessor such renewal
     policy or certificate at least sixty (60) days before the expiration of any
     existing policy.  All such policies shall be issued by companies rated not
     lower than "A-X " by A.M. Best Co. licensed to do business in the state in
     which the Premises are located, and all such policies shall contain a
     provision whereby the same cannot be cancelled or modified unless Sublessor
     is given at least sixty (60) days' prior written notice by certified or
     registered mail of such cancellation or modification.

     C. Sublessor's Insurance.  Sublessor shall maintain such insurance as is
        ---------------------
     required as "Tenant" under the Prime Lease.

     D. Contractor's Insurance.  Sublessor and Subtenant shall require any
        ----------------------
     contractor of Sublessor or Subtenant, respectively, performing work in, on
     or about the Premises to obtain and keep in full force and effect, at no
     expense to the other, (i) a commercial general public liability insurance
     policy for the Premises and adjacent areas, the conduct of its work
     therein, and the acts or omissions of such additional insured, with the
     coverages set forth in Section 12A(i) above; (ii) worker's compensation or
                            --------------
     similar insurance in form and amounts required by applicable Laws; and
     (iii) comprehensive automobile liability insurance including owned, non-
     owned and hired car coverage in an

                                       10
<PAGE>

     amount not less than $3,000,000 combined single limit for bodily injury or
     death and for property damage. The parties shall provide certificates of
     such insurance to one another prior to commencing any construction in, on
     or about the Premises.

     E. Waiver of Subrogation Rights.  Subtenant hereby releases and waives its
        ----------------------------
     rights of recovery against Landlord under the Prime Lease to the extent
     that Sublessor waived its rights of recovery against Landlord under the
     Prime Lease.  Neither Sublessor nor Subtenant shall be liable to the other
     or to any insurance company (by way of subrogation or otherwise) insuring
     the other party for any loss of or damage to any building, structure or
     other tangible property, or any resulting loss of income, or losses under
     worker's compensation laws, even though such loss or damage might have been
     caused by the negligence of such party, its agents or employees, if any
     such loss or damage is covered by (or was required under this Sublease to
     be covered by) insurance benefiting the party suffering such loss or
     damage, to the extent of the proceeds of such insurance (or the amount of
     coverage required under this Sublease if such insurance was not obtained or
     maintained).  Subtenant will cause its insurance carriers to include waiver
     of subrogation clauses or endorsements in favor of Landlord and Sublessor.
     Sublessor will cause its insurance carriers to include waiver of
     subrogation clauses or endorsements in favor of Landlord and Subtenant.

13.  SUBORDINATE TO PRIME LEASE.
     --------------------------

          This Sublease is and shall be subject and subordinate to the Prime
     Lease, and to the matters to which the Prime Lease is or shall be subject
     and subordinate.  A copy of the Prime Lease has been delivered to and
     examined by Subtenant.  The terms, covenants and conditions set forth in
     the Prime Lease are incorporated herein by reference, except Sections 37
     and 38.10 and except to the extent that they are inapplicable or otherwise
     modified by the provisions of this Sublease, and Sublessor and Subtenant
     agree to be bound by all of the provisions of the Prime Lease applicable to
     the Premises, except that Subtenant shall be obligated to pay the rent
     provided in this Sublease, and not the rent provided in the Prime Lease.
     Subtenant shall not in any event have any rights in respect of the Premises
     greater than Sublessor's rights under the Prime Lease.  Subtenant shall not
     do or permit to be done any act or thing which may constitute a breach or
     violation of any term, covenant or condition of the Prime Lease by the
     tenant thereunder, whether or not such act or thing is permitted under the
     provisions of this Sublease.  Nothing contained in this Sublease shall be
     construed to create privity of estate or of contract between Subtenant and
     Landlord.

14.  TERMINATION OF PRIME LEASE.
     --------------------------

     A.  Termination Prior to Expiration Date of Sublease.  If for any reason,
         ------------------------------------------------
other than the default of Sublessor under the Prime Lease, the term of the Prime
Lease shall have terminated prior to the Expiration Date, this Sublease shall
thereupon be terminated and Sublessor shall not

                                       11
<PAGE>

be liable to Subtenant by reason thereof. Sublessor shall provide Subtenant
immediate notice of any default under the Prime Lease and the Subtenant shall
have the right (but not the obligation) to cure any such default within the
applicable cure period. In the event of termination of the Prime Lease pursuant
to casualty or condemnation of the Premises, this Sublease shall be terminated
effective on the date of termination of the Prime Lease and Subtenant shall have
no claim against Sublessor.

     B.  Casualty or Condemnation.  In the event of casualty or condemnation,
         ------------------------
this Sublease shall continue in effect if the Prime Lease is not terminated, and
the applicable provisions of the Prime Lease shall govern.  In no event shall
Subtenant be required to rebuild or restore the Premises, the Prime Lease
Premises or the Building or indemnify or otherwise reimburse Sublessor in the
event of a casualty.  Notwithstanding the foregoing, where tenant under the
Prime Lease is provided a right to terminate, likewise Subtenant shall be
provided such right to terminate this Sublease, notice of such termination to be
provided by Subtenant within the same time periods provided under the Prime
Lease.  Moreover, in the event of a public taking or other condemnation,
Subtenant shall have the right to bring a separate claim, at its sole expense,
against such public authority for any damages Subtenant may suffer in connection
with the taking.

15.  NOTICES.
     -------

          All notices, consents, approvals, demands and requests (collectively,
     "Notices") delivered by either party to the other hereunder shall be in
      -------
     writing and shall be sent either by United States registered or certified
     mail and deposited in a United States Post Office, return receipt requested
     and postage prepaid, or by reputable overnight air courier such as Federal
     Express.  Notices which are served upon Sublessor or Subtenant by mail in
     the manner provided herein shall be deemed to have been given or served for
     all purposes hereunder on the third business day next following the date on
     which such Notice shall have been mailed as aforesaid.  After delivery of
     possession of the Premises to Subtenant, all Notices given to Subtenant
     shall be addressed to Subtenant at the Premises; until such delivery,
     notice to Subtenant shall be given at its address set forth at the head of
     this Sublease.  All Notices given to Sublessor shall be addressed to
     Sublessor at its address set forth at the head of this Sublease, to the
     attention of Thomas C. McLaughlin, Director of Real Estate, with a copy to
     John Iatesta, Esquire, Senior Legal Counsel.  Sublessor or Subtenant may
     from time to time change the names and/or addresses to which Notices given
     to either of them shall be addressed and sent as aforesaid, by designating
     such other names and/or addresses in a notice given to the other party in
     accordance with the provisions of this Section 15.
                                            ----------

                                       12
<PAGE>

16.  DEFAULT.
     -------

     A.  Event of Default.  Each of the following shall be deemed to be an
         ----------------
"Event of Default" by Subtenant and a breach by Subtenant hereunder:  (i) except
-----------------
as otherwise provided in Section 9, the assignment of this Sublease or the
subletting of the Premises, whether by operation of the law or otherwise,
without the prior written consent of Sublessor, (ii) Subtenant's failure to take
possession of the Premises within ten (10) business days after tender of
possession, (iii) the non-payment of any Base Rent or Additional Rent Charges or
any part thereof within ten (10) days after written notice that the same is due
(no more than one written notice per any twelve month period during the Term
shall be required), or failure to make any other payment herein provided for,
and the continuance of such non-payment for ten (10) days after Sublessor shall
have given written notice of nonpayment to Subtenant, or (iv) the default in the
performance of any other obligation of Subtenant under this Sublease, and the
continuance of such default for fifteen (15) days after Sublessor shall have
given to Subtenant a written notice specifying the nature of such default, but
if said default shall be of such nature that it cannot reasonably be cured or
remedied within said fifteen (15) day period, same shall not be deemed an Event
of Default if Subtenant shall have commenced in good faith the curing or
remedying of such default within such fifteen (15) day period and shall
thereafter continuously and diligently proceed therewith to completion.

     B.  Remedies.  In the event of Subtenant's default or the occurrence or
         --------
existence of an Event of Default, Subtenant shall pay to Sublessor, on demand,
such expenses as Sublessor may incur, including, without limitation, reasonable
attorneys' fees, court costs, disbursements, and any and all other costs
incurred by Sublessor in enforcing the performance of any obligation of
Subtenant under this Sublease.  If an Event of Default occurs, Sublessor shall
have the following rights and remedies, in addition to all rights and remedies
available under law or equity: (i) Sublessor may declare this Sublease
terminated upon written notice to Subtenant; and/or (ii) Sublessor or its
agents, servants, representatives, successors or assigns may, immediately or at
any time thereafter, re-enter and resume possession of the Premises and remove
all persons and property therefrom, either by summary dispossess proceedings or
by a suitable action or proceeding at law, or by force or otherwise, without
being liable for any damages therefor, and no such re-entry shall be deemed an
acceptance or surrender of this Sublease; and/or (iii) Sublessor may, but shall
have no obligation to, in its own name, but as agent for Subtenant if this
Sublease is not terminated, relet the whole or any portion of the Premises for
any period equal to or greater or less than the period which would have
constituted the balance of the Term, for any sum which Sublessor may deem
reasonable, to any tenant(s) which Sublessor may deem appropriate, and Sublessor
may grant concessions, including free rent.  In the event of any breach or
threatened breach by Subtenant of any of the covenants or provisions of this
Sublease, Sublessor shall have the right of injunction and the right to invoke
any remedy allowed at law or in equity; mention in this Sublease of any
particular remedy shall not preclude Sublessor from any other remedy at law or
in equity.

     C.  Damages.  Sublessor shall in no event be liable in any way whatsoever
         -------
for its failure or refusal to relet the Premises or any part thereof; provided,
however, that Sublessor shall use reasonable efforts to mitigate its damages.
Sublessor shall be entitled to recover from

                                       13
<PAGE>

Subtenant, and Subtenant shall pay to Sublessor immediately upon demand by
Sublessor, the amounts equal to all of the expenses incurred by Sublessor in
connection with (i) recovering possession of the Premises, (ii) any reletting(s)
of the Premises and related brokerage costs, including without limitation
reasonable costs for making alterations, repairing or otherwise preparing the
Premises for reletting(s), (iii) court costs, and (iv) reasonable attorneys'
fees incurred in connection with any of the foregoing. Sublessor shall also be
entitled to recover from Subtenant for each month of the balance of the Term or
the period which would otherwise have constituted the balance of the Term, the
amount, if any, by which the sum of each monthly installment of the Base Rent
which would have been payable had there been no Event of Default, plus the
amount of Additional Rent which would have been payable had there been no Event
of Default, exceeds the net amount, if any, of the rents collected on account of
the reletting(s) of the Premises for the month in question, which amounts shall
be due and payable by Subtenant to Sublessor in monthly installments on the last
day of each month, and any suit brought to collect the amount of the deficiency
for any month shall not prejudice in any way the rights of Sublessor to collect
the deficiency for any subsequent month by way of a similar proceeding.
Sublessor, at Sublessor's option, may make such alterations and repairs in and
to the Premises as Sublessor in its reasonable judgment considers advisable and
necessary for the purpose of reletting the Premises, and the making of such
alterations, and repairs shall not operate or be construed to release Subtenant
from liability hereunder as aforesaid.

     D.  Late Charges and Returned Check Charges.  If payment of any Base Rent
         ---------------------------------------
or Additional Rent is not made by the fifth (5th) day after the date on which
such amount was due and payable, but only if such late payment occurs more than
once in any calendar year during the Term, Subtenant shall pay as a late charge
the greater of (i) Two Hundred Fifty and No/100 Dollars ($250.00), or (ii) five
percent (5%) of the overdue payment, and interest on the amount overdue at the
rate of ten percent (10%) per annum (the "Default Rate") from the date on which
                                          ------------
such amount was due until the date of payment, as reimbursement of Sublessor's
expenses incurred as a result of Subtenant's failure to make prompt payment.  In
addition to any late charges or other remedies available to Sublessor, if any
check is returned to Sublessor by Subtenant's bank by reason of insufficient
funds, uncollected funds or otherwise, Subtenant shall pay to Sublessor a return
check administrative charge equal to the lesser of the then current maximum
amount allowable under Virginia law or One Hundred Fifty Dollars ($150.00).
Subtenant shall pay the late charges and return check administrative charges for
any month as Additional Rent on the first day of the following month.

     E.  Additional Right of Sublessor to Cure Subtenant's Defaults.  Sublessor
         ----------------------------------------------------------
may, but shall not be obligated to, cure, at any time upon ten (10) days notice
or without notice in case of emergency, any default(s) by Subtenant under this
Sublease, and Subtenant shall pay to Sublessor on demand all costs and expenses
incurred by Sublessor in curing such default(s), including, without limitation,
court costs and reasonable attorneys' fees and disbursements in connection
therewith, together with interest on the amount of costs and expenses so
incurred at the Default Rate.

     F.  Default by Sublessor.  Sublessor shall only be deemed to be in default
         --------------------
hereunder if Sublessor violates or fails to perform any covenant or agreement
hereunder which is not

                                       14
<PAGE>

observed or performed by Sublessor within thirty (30) days after the receipt by
Sublessor of written notice from Subtenant specifically identifying such
violation or failure. Sublessor shall not be considered in default so long as
Sublessor commences to cure the violation within said thirty (30) day period and
diligently pursues the completion of such cure. In the event of a default
hereunder or under the Prime Lease existing beyond any applicable cure period,
by Sublessor, Subtenant shall have all the remedies available under the law or
in equity.

17.  WAIVER OF JURY TRIAL.
     --------------------

          SUBLESSOR AND SUBTENANT EACH HEREBY WAIVES ALL RIGHT TO TRIAL BY JURY
     IN ANY SUMMARY OR OTHER ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT OF
     OR IN ANY WAY CONNECTED WITH THIS SUBLEASE, THE RELATIONSHIP OF SUBLESSOR
     AND SUBTENANT, THE PREMISES OR THE USE AND OCCUPANCY THEREOF, OR ANY CLAIM
     OF INJURY OR DAMAGES.

18.  END OF TERM.
     -----------

          At the expiration or sooner termination of the Term, Subtenant shall
     quit and surrender to Sublessor the Premises, broom clean, free of all
     occupants, and in good condition, ordinary wear and tear and damage by fire
     and any other casualty excepted.  At such expiration or sooner termination,
     Subtenant shall remove from the Premises all property of Subtenant (not to
     include Subtenant's initial up-fit, which may be removed at Subtenant's
     sole discretion), including its sign(s), and, at the option of Sublessor,
     shall remove all Alterations made by Subtenant to the Premises (other than
     Subtenant's initial up-fit) but only so long as Sublessor notified
     Subtenant in writing at the time Sublessor approved the Alteration(s) that
     such Alteration(s) were not to remain with the Premises and Subtenant shall
     repair all damage to the Premises caused by any and all such removal and
     restore the Premises to the condition in which they were prior to the
     installation of the items so removed, including the areas where Subtenant
     affixed its sign(s).  Any property of Subtenant not so removed may be
     deemed to be abandoned, or Sublessor may remove the same and restore any
     damage, at Subtenant's expense.  Subtenant shall also deliver to Sublessor
     a decontamination report, issued by a qualified environmental engineering
     company, for the Premises.  Such report shall indicate that any and all
     Hazardous or Regulated Materials (as defined in Section 22) have been
     removed from the Premises, and that there have been no spills or releases
     of such Hazardous or Regulated Materials.

19.  HOLDOVER.
     --------

          If Subtenant remains in possession of the Premises after the
     expiration or termination of the Term, Subtenant shall be deemed to be
     occupying the Premises as a tenant from month to month at the sufferance of
     Sublessor subject to all of the provisions of this Sublease, except that
     the Base Rent shall be at a monthly rate equal to 150% of the monthly Base
     Rent in effect during the last month of the Term.  Subtenant shall give to

                                       15
<PAGE>

     Sublessor at least thirty (30) days' prior written notice of any intention
     to quit the Premises.

          Notwithstanding the foregoing provisions of this Section 19, if
                                                           ----------
     Subtenant holds over after the expiration or termination of the Term and
     Sublessor desires to regain possession of the Premises, then Sublessor, at
     its option, may forthwith re-enter and take possession of the Premises
     without process, or by any legal process in force in the jurisdiction in
     which the Prime Lease Premises is located.  Any rental amounts for such
     hold over period which are deposited into Sublessor's rental account shall
     not be deemed accepted by Sublessor if Sublessor promptly returns such
     rental amounts to Subtenant, in any event within ten (10) business days of
     receipt of such sums from Subtenant.  Nothing herein shall limit
     Sublessor's right to recover damages pursuant to this Sublease and such
     other damages as are available to Sublessor at law or in equity (including
     but not limited to any and all liability to Landlord or otherwise caused by
     such holdover).

20.  BROKERAGE.
     ---------

          Sublessor and Subtenant represent to one another that, except for
     Advantis GVA and The Oppenheim Group, no broker or other person had any
     part, or was instrumental in any way, in bringing about this Sublease, and
     the parties shall pay, and shall indemnify, defend and hold harmless, one
     another from and against, any claims made by any other broker or other
     person for a brokerage commission, finder's fee, or similar compensation,
     by reason of or in connection with this Sublease, and any loss, liability,
     damage, cost and expense (including, without limitation, reasonable
     attorneys' fees) in connection with such claims if such broker or other
     person claims to have had dealings with Sublessor or Subtenant,
     respectively.

21.  FINANCIAL STATEMENTS AND ESTOPPEL CERTIFICATES.
     ----------------------------------------------

          Subtenant shall, within fifteen (15) days after each and every request
     by Sublessor, execute, acknowledge and deliver to Sublessor either or both
     of the following: (a) an annual financial statement, and (b) a statement in
     writing (i) certifying that this Sublease is unmodified and in full force
     and effect (or if there have been modifications, that the same is in full
     force and effect as modified, and stating the modifications), and the
     Commencement Date, Rent Commencement Date and Expiration Date, (ii)
     specifying the dates to which the Base Rent and Additional Rent have been
     paid, (iii) stating whether or not, to the best knowledge of Subtenant,
     Sublessor is in default under this Sublease, and, if so, specifying each
     such default, (iv) stating whether or not, to the best knowledge of
     Subtenant, any event has occurred which with the giving of notice or
     passage of time, or both, would constitute a default by Sublessor under
     this Sublease, and, if so, specifying each such event, (v) stating whether
     Subtenant has exercised any option(s) to extend the Term of this Sublease,
     and, if so, specifying each such extension, and (vi) any other matter as
     may be reasonably requested.  Any such statement delivered pursuant to this
     Section 21 may be relied upon by any prospective assignee or transferee of
     ----------
     the leasehold estate under the Prime Lease.

                                       16
<PAGE>

22.  HAZARDOUS SUBSTANCES.
     --------------------

          Sublessor shall deliver to Subtenant copies of any and all existing
     reports, studies, or environmental assessment of which Sublessor is aware
     or later becomes aware, that address the environmental conditions of the
     Building or the Premises, including records concerning the disposal of any
     prior spills or releases of Hazardous Materials (defined below) and any
     decontamination reports for the Building.  Subtenant shall not use,
     generate, manufacture, produce, store, treat, dispose of or permit the
     escape of, on, under, about or from the Premises, or any part thereof, any
     asbestos or any flammable, explosive, hazardous, toxic, contaminating,
     polluting matter, waste, or substance or related injurious materials,
     whether injurious by themselves or in combination with other materials
     (collectively "Hazardous Materials") or any material, substance, or
                    -------------------
     chemical which is regulated by any federal, state or local law, rule,
     ordinance or regulation (collectively "Regulated Materials"), unless said
                                            -------------------
     Hazardous Materials and/or Regulated Materials are of the type normally
     used in the ordinary course of operations at or maintenance of Subtenant's
     headquarters office space and support facility that include analytical,
     research and development activities.  Subtenant shall comply with all Laws
     with respect to such production, use and storage, including, without
     limitation, the removal and disposal of such Hazardous Materials and/or
     Regulated Materials at the expiration or earlier termination of the
     Sublease Term.  Subtenant shall defend (by counsel reasonably acceptable to
     Sublessor), indemnify and hold harmless Landlord, Sublessor and each of
     Sublessor's partners, employees, agents, attorneys, successors and assigns,
     from and against any and all claims, liabilities, penalties, forfeitures,
     losses or expenses (including reasonable attorney's fees), or death of or
     injury to any person or damage to any property whatsoever ("Environmental
     Claims"), arising from or caused in whole or in part, directly or
     indirectly by (i) the presence in, on, under or about the Premises, or
     discharge in or from the Premises of any Hazardous Materials and/or
     Regulated Materials introduced into the Premises by Subtenant or caused by
     Subtenant or Subtenant's use, analysis, storage, removal, transportation,
     disposal, release, threatened release, discharge or generation of Hazardous
     Materials and/or Regulated Materials to, in, on, under, about or from the
     Premises; or (ii) Subtenant's failure to comply with any federal, state,
     county, municipal, local or other law, rule, ordinance and regulation now
     or hereafter in effect relating to the industrial hygiene, environmental
     protection, use, analysis, generation, manufacture, purchase,
     transportation, storage, removal and disposal of Hazardous Materials and/or
     Regulated Materials.  In connection with, or as a result of (i) or (ii)
     above, Subtenant's obligations hereunder shall not include reimbursement
     for Environmental Claims that are the result of any preexisting condition
     of the Building or Premises or are caused in any part by the negligent acts
     or omissions of the Sublessor or Landlord, their employees or agents and in
     such situations the Subtenant's obligations hereunder shall be limited to
     its allocable share of responsibility for the Environmental Claims.   In
     connection with, or as a result of, (i) or (ii) above and subject to the
     limitations set forth herein, Subtenant's obligations hereunder shall
     include, without limitation and whether foreseeable or unforeseeable, all
     costs of any required or necessary testing, repair, cleanup, removal,
     detoxification or decontamination of or from the

                                       17
<PAGE>

     Premises and the preparation and implementation of any closure, remedial
     action, site assessment costs or other required plans in connection
     therewith. Subtenant's obligations hereunder shall survive the expiration
     or earlier termination of this Sublease. For purposes of this Section 22,
                                                                   ----------
     any acts or omissions of Subtenant whereby employees, agents, assignees,
     contractors or subcontractors of Subtenant or others are acting for or on
     behalf of Subtenant (whether or not they are negligent, intentional,
     willful or unlawful), will be strictly attributable to Subtenant.

23.  MISCELLANEOUS COVENANTS.
     -----------------------

     A.  No Waste.  Subtenant shall not commit or suffer to be committed any
         --------
waste upon the Premises or any nuisance or other act or thing which may
materially disturb the quiet enjoyment of any other tenant or occupant of the
Innsbrook Corporate Center.

     B.  Intentionally deleted.
         ----------------------

     C.  Insurance Premiums.  Subtenant shall not do or permit to be done any
         ------------------
act or thing in or upon the Premises which will or may invalidate or be in
conflict with fire insurance policies covering the Building, or any part thereof
or fixtures and property therein, and shall comply with all rules, orders,
regulations or requirements of the Board of Fire Underwriters having
jurisdiction, or any other similar body, and shall not do, or permit to be done,
anything in or upon the Premises, or bring or keep anything therein, which shall
increase the rate of fire insurance on the Building, or the Land.  If by reason
of failure of Subtenant to comply with the provisions of this Section, the fire
insurance rate shall at any time be higher than it otherwise would be, then, in
addition to the right of Sublessor to the exercise of any and all other remedies
available under this Sublease, Subtenant shall reimburse Sublessor on demand as
Additional Rent for the portion of all fire insurance premiums which shall have
been then or in the future charged because of such violation by Subtenant and
which Sublessor shall have, or may be required to have, paid on account of an
increase in rate in its own policies of insurance.

     D.  Consents and Approvals.   In any instance when Sublessor's consent or
         ----------------------
approval is required under this Sublease, Sublessor's refusal to consent to or
approve  any matter or thing shall be deemed reasonable if such consent or
approval has not been obtained from the Landlord.

     E.  No Waiver.  The failure of Sublessor to insist in any one or more cases
         ---------
upon the strict performance or observance of any obligation of Subtenant
hereunder or to exercise any right or option contained herein shall not be
construed as a waiver or relinquishment for the future of any such obligation of
Subtenant or any right or option of Sublessor.  Sublessor's receipt and
acceptance of Base Rent or Additional Rent, or Sublessor's acceptance of
performance of any other obligation by Subtenant, with knowledge of Subtenant's
breach of any provision of this Sublease, shall not be deemed a waiver of such
breach. No waiver by Sublessor of any term, covenant or condition of this
Sublease shall be deemed to have been made unless expressed in writing and
signed by Sublessor.

                                       18
<PAGE>

     F.  Successors and Assigns.  The provisions of this Sublease, except as
         ----------------------
herein otherwise specifically provided, shall extend to, bind and inure to the
benefit of the parties hereto and their respective personal representatives,
heirs, successors and permitted assigns.  In the event of any assignment or
transfer of the leasehold estate under the Prime Lease, the transferor or
assignor, as the case may be, shall be and hereby is entirely relieved and freed
of all obligations under this Sublease.

     G.  Interpretation.  This Sublease shall be governed by and construed in
         --------------
accordance with the laws of the state in which the Premises are located, without
regard to conflicts of laws principles.  If any provision of this Sublease or
the application thereof to any person or circumstance shall, for any reason and
to any extent, be invalid or unenforceable, the remainder of this Sublease and
the application of that provision to other persons or circumstances shall not be
affected but rather shall be enforced to the extent permitted by law.  The table
of contents, captions, headings and titles, if any, in this Sublease are solely
for convenience of reference and shall not affect its interpretation.  This
Sublease shall be construed without regard to any presumption or other rule
requiring construction against the party causing this Sublease to be drafted.
If any words or phrases in this Sublease shall have been stricken out or
otherwise eliminated, whether or not any other words or phrases have been added,
this Sublease shall be construed as if the words or phrases so stricken out or
otherwise eliminated were never included in this Sublease and no implication
shall be drawn from the fact that said words or phrases were so stricken out or
otherwise eliminated.  Each covenant, agreement, obligation or other provision
of this Sublease shall be deemed and construed as a separate and independent
covenant of the party bound by, undertaking or making same, not dependent on any
other provisions of this Sublease unless otherwise expressly provided.  All
terms and words used in this Sublease, regardless of the number or gender in
which they are used, shall be deemed to include any other number and any other
gender as the context may require.  The word "person" as used in this Sublease
shall mean a natural person or persons, a partnership, a corporation or any
other form of business or legal association or entity.  Time shall be of the
essence of each and every obligation of Subtenant under this Sublease.

     H.  No Reservation.  No employee or agent of Sublessor, no broker, and no
         --------------
agent of any broker has authority to make or agree to take a sublease or any
other agreement or undertaking in connection herewith, including but not limited
to the modification, amendment or cancellation of a sublease.  The mailing or
delivery of this document by an employee or agent of Sublessor, any broker or
the agent of any broker to a potential Subtenant, its agent or attorney shall
not be deemed an offer of Sublessor or a reservation of or option for the
Premises until such time as a sublease, duly executed by Sublessor and
Subtenant, is delivered to such potential Subtenant, its agent or attorney.

     I.  No Partnership.  Nothing contained in this Sublease shall be deemed or
         --------------
construed to create a partnership or joint venture of or between Sublessor and
Subtenant, or to create any relationship other than that of sublandlord and
subtenant.

     J.  No Representations.  Neither Sublessor nor any agent of Sublessor has
         ------------------
made any representations or promises with respect to the Premises, the Building
or the Land except as

                                       19
<PAGE>

expressly set forth in this Sublease, and no rights, privileges, easements or
licenses are granted to Subtenant except as expressly set forth in this
Sublease.

     K.  Quiet Enjoyment.  Sublessor covenants that if Subtenant pays the rent
         ---------------
and performs all of the covenants, agreements and conditions specified in this
Sublease to be performed by Subtenant, Subtenant shall for the Term freely,
peaceably and quietly occupy and enjoy the full possession of the Premises
without molestation or hindrance.

     L.  Complete Agreement.  There are no representations, agreements,
         ------------------
arrangements or understandings, oral or written, between the parties relating to
the subject matter of this Sublease which are not fully expressed in this
Sublease.  This Sublease cannot be changed or terminated orally or in any manner
other than by a written agreement executed by both parties.

     M.  Force Majeure.  In the event that Sublessor or Subtenant shall be
         -------------
delayed or hindered in or prevented from the performance of any act required
hereunder, other than the payment of money, by reason of strikes, lockouts,
labor troubles, inability to procure materials, failure of power, restrictive
governmental laws, regulations, orders or decrees, riots, insurrection, war,
acts of God, inclement weather, or other reason beyond Sublessor's or
Subtenant's control, then performance of such act shall be excused for the
period of the delay and the period for the performance of any such act, other
than the payment of money, shall be extended for a period equivalent to the
period of such delay.

     N.  Landlord Consent.  This Sublease is subject to receipt of Landlord's
         ----------------
consent to the Sublease within thirty (30) days after the Sublease is fully
executed.  Sublessor shall use its best efforts to obtain the Landlord's consent
and Subtenant and Sublessor shall cooperate with any reasonable request of the
Landlord to assist in obtaining such consent.

     O.  Subordination and NonDisturbance.  Subtenant's interest under this
         ---------------------------------
Sublease shall be subject and subordinate to the lien of any mortgage or similar
lien which Sublessor may now or hereafter place on the Premises and to all the
terms, conditions and provisions thereof and to any renewals, extensions,
modifications or replacements thereof; provided, however, that if the Sublease
is otherwise in full force and effect and there are no material defaults
hereunder on the part of Subtenant, beyond the expiration of any applicable cure
period, such mortgagee shall agree that upon foreclosure or sale of Sublessor's
interest in the Premises, this Sublease shall not be terminated nor affected by
said foreclosure or sale, and the mortgagee shall agree that any foreclosure or
sale of the Premises pursuant to its rights under the mortgage, shall be made
subject to this Sublease and the right of Subtenant hereunder.  Subtenant agrees
to attorn to any mortgagee or such person as may have purchased the Premises
upon sale, as its new Sublessor and the Sublease shall continue between
Subtenant and the mortgagee or other such person upon the terms and conditions
of this Sublease.  The parties hereto shall agree to execute such documents as
may be reasonably necessary to effectuate said subordination and nondisturbance.

                                       20
<PAGE>

     IN WITNESS WHEREOF, Sublessor and Subtenant have hereunto executed this
     Sublease as of the day and year first above written.

                                    SUBLESSOR:

                                    RHODIA INC.

                                    By:  _______________________[SEAL]
                                    Name: ______________________
                                    Title: _____________________

                                    SUBTENANT:

                                    INSMED INCORPORATED

                                    By:  _______________________[SEAL]
                                    Name:  _____________________
                                    Title:  ____________________

                                       21
<PAGE>

                                   EXHIBIT A
                                   ---------

                 [PLAN OF CENTER SHOWING LOCATION OF PREMISES]

                                       1
<PAGE>

                                  EXHIBIT A-1
                                  -----------

                    [PLAT SHOWING RESERVED PARKING SPACES]

                                       2
<PAGE>

                                   EXHIBIT B
                                   ---------

1.   Twenty (20) modular work stations

2.   Sixteen (16) metal office suites to outfit lab offices.

3.   One (1) rolling files system.

4.   Eleven (11) Cafeteria tables and sixty five (65) chairs.

5.   Patio furniture consisting of three (3) tables and one (1) bench.

6.   Existing kitchen equipment.

7.   One (1) two-section board room table and twenty (20) chairs.

                                       1
<PAGE>

                                   EXHIBIT C
                                   ---------

                              [Construction Plans]

                                       1
<PAGE>

                                  Schedule 1
                                  ----------

               Outline for the pro-ration of utility charges for
               -------------------------------------------------
                  4851 Lake Brook Drive, Glen Allen, Virginia
                  -------------------------------------------

Natural Gas

The natural gas service to the building is provided by the City of Richmond
Department of Utilities and is billed monthly.  So long as such gas service is
used solely by the Subtenant, Subtenant shall be responsible for the entire
invoiced service bill from the Department of Utilities.  In the event Subtenant
is not the exclusive end-user of the gas service, Sublessor shall separately
meter the Office Space and the Laboratory Space and charge Subtenant for its
actual usage.

Water and Sewer

The water and sewer service to the building is provided by Henrico County
Department of Public Utilities and is billed every two months.  The pro-ration
shall apply 66% as the Subtenant share and 34% as the Second Floor Tenant's
share, so long as Subtenant's use of the water and sewer is consistent with
traditional office use.  In the event that Subtenant's use of the water and
sewer in the Laboratory Space or the cafeteria is higher than for traditional
office use, Subtenant's pro rata share may be increased; provided, however that
Sublessor shall provide sufficient documentation supporting such increase.  In
the event that Subtenant disputes such increase, Sublessor and Subtenant shall
hire a mutually acceptable, independent third party, qualified in such matters,
to resolve the dispute.  The parties agree to abide by such third party's
findings concerning the Subtenant's pro rata share of the water and sewer
expenses.

Electrical

The electrical service to the building is provided by Dominion Virginia Power
and is billed monthly.  This service shall be pro-rated between Subtenant and
the Second Floor Tenant as outlined in the following "Energy Distribution Model:

Energy Distribution Model
-------------------------
Note:  The Dominion Virginia Power bill represents the amount of energy consumed
-----
for the entire building each month.  Two sub-meters have been installed in the
first floor mechanical room for the purpose of pro-rating each tenant's share of
the bill.
Common Area:  The common area which primarily includes, but is not limited to,
------------
lighting and power for the lobby, elevator,  stairwell, and exterior lighting
shall be estimated by a qualified electrical engineer for purposes of pro-ration
and shall apply 66% as Subtenant's share and 34% as the Second Floor Tenant's
share.
Sub-Meter No. 1:  Meters the actual kwh electrical use on the second floor panel
----------------
load, i.e. outlets & lights
Sub-Meter No. 2:   Meters one of the two HVAC roof top units which are designed
----------------          ---
to run in tandem with equal electrical consumption.

                                       2
<PAGE>

Example:
--------

<TABLE>
     <S>                                                                                     <C>
     Dominion Virginia Power monthly bill is $15,000 (all charges) for 300,000kwh = $.05/kwh

     Allocation:
     Sub-Meter No. 1 shows a use of 42,000 kwh x $.05     = $2,100
     Sub-Meter No. 2 shows a use of 62,000 kwh x $.05     = $3,100
                                   Sub-Meter Total        = $5,200

     Common Area Use is (say 10%) or $1,500 x 34% for Second Floor Tenant                    $  510

                               Total share for Second Floor Tenant =                         $5,710

     Subtract $5,710 from the $15,000 bill and Subtenant's Total Share =                     $9,290
</TABLE>

                                       3

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