Document:

Exhibit 4.3

    THE SECURITIES REPRESENTED BY THIS INSTRUMENT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR QUALIFIED UNDER
      APPLICABLE STATE SECURITIES LAWS AND HAVE BEEN TAKEN FOR INVESTMENT PURPOSES ONLY AND NOT WITH A VIEW TO OR FOR SALE IN CONNECTION WITH ANY DISTRIBUTION THEREOF. THE SECURITIES MAY NOT BE SOLD OR OTHERWISE TRANSFERRED IN THE ABSENCE OF SUCH
      REGISTRATION AND QUALIFICATION WITHOUT, EXCEPT UNDER CERTAIN SPECIFIC LIMITED CIRCUMSTANCES, AN OPINION OF COUNSEL FOR THE HOLDER, CONCURRED IN BY COUNSEL FOR THE COMPANY THAT SUCH REGISTRATION AND QUALIFICATION ARE NOT REQUIRED.

    [______________]

    STOCK PURCHASE WARRANT

      To Purchase Shares of Series E‐1 Preferred Stock of

      CASTLE BIOSCIENCES, INC.

    THIS CERTIFIES that, for value received, [__________] (the “Investor”), is entitled, upon the terms and subject to
      the conditions hereinafter set forth, at any time on or after the date set forth in Section 2 below and on or prior to the close of business on the date ten (10) years after the date hereof; but not thereafter, to subscribe for and purchase, from
      CASTLE BIOSCIENCES, INC., a Delaware corporation (the “Company”), [_______] shares of Series E‐1 Preferred Stock of the Company at a purchase price of $[____] per share. The purchase price and the number of shares for which the Warrant is exercisable
      shall be subject to adjustment as provided herein. This Warrant is one of the Warrants issued pursuant to that Amendment No. 1 to Convertible Subordinated Promissory Notes of even date herewith by and among the Company and the Note Holders (as
      defined therein) (the “Notes Amendment”).

    1.          Title of Warrant. Prior to the expiration hereof and subject to compliance with applicable laws, this Warrant and all rights hereunder are transferable, in whole
        or in part, at the office or agency of the Company, referred to in Section 2 hereof; by the holder hereof in person or by duly authorized attorney, upon surrender of this Warrant together with the Assignment Form annexed hereto properly endorsed.

    2.          Exercise of Warrant. The purchase rights represented by this Warrant are exercisable by the registered holder hereof; in whole or in part, at any time (i) after
        the Initial Closing (as defined in that Series E‐1, Series E-2 and Series E-3 Preferred Stock Purchase Agreement of even date herewith by and among the Company and the Investors (as defined therein)) and (ii) before the close of business on the
        date ten (10) years after the date hereof, by the surrender of this Warrant and the Notice of Exercise annexed hereto duly executed at the office of the Company, in Friendswood, Texas (or such other office or agency of the Company as it may
        designate by notice in writing to the registered holder hereof at the address of such holder appearing on the books of the Company), and upon payment of the purchase price of the shares thereby purchased (by cash or by check or bank draft payable
        to the order of the Company or by cancellation of indebtedness of the Company to the holder hereof, if any, at the time of exercise in an amount equal to the purchase price of the shares thereby purchased); whereupon the holder of this Warrant
        shall be entitled to receive a certificate for the number of shares of Series E‐1 Preferred Stock so purchased. The Company agrees that if at the time of the surrender of this Warrant and purchase the holder hereof shall be entitled to exercise
        this Warrant, the shares so purchased shall be and be deemed to be issued to such holder as the record owner of such shares as of the close of business on the date on which this Warrant shall have been exercised as aforesaid.

    
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    Certificates for shares purchased hereunder shall be delivered to the holder hereof within a reasonable time after
      the date on which this Warrant shall have been exercised as aforesaid.

    The Company covenants that all shares of Series E‐1 Preferred Stock which may be issued upon the exercise of rights
      represented by this Warrant will, upon exercise of the rights represented by this Warrant, be fully paid and nonassessable and free from all taxes, liens and charges in respect of the issue thereof.

    3.          No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon the exercise of this Warrant. With respect to any
        fraction of a share called for upon the exercise of this Warrant, an amount equal to such fraction multiplied by the then current price at which each share may be purchased hereunder shall be paid in cash to the holder of this Warrant.

    4.          Charges, Taxes and Expenses. Issuance of certificates for shares of Series E‐1 Preferred Stock upon the exercise of this Warrant shall be made without charge to
        the holder hereof for any issue or transfer tax or other incidental expense in respect of the issuance of such certificate, all of which taxes and expenses shall be paid by the Company, and such certificates shall be issued in the name of the
        holder of this Warrant or in such name or names as may be directed by the holder of this Warrant; provided, however, that in the event certificates for shares of Series E‐1 Preferred Stock are to be issued in a name other than the name of the
        holder of this Warrant, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form attached hereto duly executed by the holder hereof; and provided further, that upon any transfer involved in the issuance or delivery of
        any certificates for shares of Series E‐1 Preferred Stock, the Company may require, as a condition thereto, the payment of a sum sufficient to reimburse it for any transfer tax incidental thereto.

    5.          No Rights as Stockholders. This Warrant does not entitle the holder hereof to any voting rights or other rights as a stockholder of the Company prior to the
        exercise thereof.

    6.          Exchange and Registry of Warrant. This Warrant is exchangeable, upon the surrender hereof by the registered holder at the above-mentioned office or agency of the
        Company, for a new Warrant of like tenor and dated as of such exchange.

    The Company shall maintain at the above-mentioned office or agency a registry showing the name and address of the
      registered holder of this Warrant. This Warrant may be surrendered for exchange, transfer or exercise, in accordance with its terms, at such office or agency of the Company, and the Company shall be entitled to rely in all respects, prior to written
      notice to the contrary, upon such registry.

    
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    7.          Loss, Theft, Destruction or Mutilation of Warrant. Upon receipt by the Company of
        evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant, and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it, and upon reimbursement to the Company of all
        reasonable expenses incidental thereto, and upon surrender and cancellation of this Warrant, if mutilated, the Company will make and deliver a new Warrant of like tenor and dated as of such cancellation, in lieu of this Warrant.

    8.          Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of any right required or granted herein
        shall be a Saturday or a Sunday or shall be a legal holiday, then such action may be taken or such right may be exercised on the next succeeding day not a legal holiday.

    9.          Early Termination and Dilution.

    (a)          Merger, Sale of Assets, etc. If at any time the Company proposes to (i) consolidate with, merge with, sell or convey all or substantially all of its assets to any
        other corporation, or effect some other form of reorganization, or (ii) effect a registered public offering of its shares, then the Company shall give the holder of this Warrant thirty days notice of the proposed effective date of such transaction
        and if the Warrant has not been exercised by the effective date of such transaction it shall terminate.

    (b)          Reclassification, etc. If the Company at any time shall, by subdivision, combination or reclassification of securities or otherwise, change any of the
        securities to which purchase rights under this Warrant exist into the same or a different number of securities of any class or classes, this Warrant shall thereafter be to acquire such number and kind of securities as would have been issuable as
        the result of such change with respect to the securities which were subject to the purchase rights under this Warrant immediately prior to such subdivision, combination, reclassification or other change. If shares of the Company’s Series E‐1
        Preferred Stock are subdivided or combined into a greater or smaller number of shares of Series E‐1 Preferred Stock, the purchase price under this Warrant shall be proportionately reduced in case of subdivision of shares or proportionately
        increased in the case of combination of shares, in both cases by the ratio which the total number of shares of Series E‐1 Preferred Stock to be outstanding immediately after such event bears to the total number of shares of Series E‐1 Preferred
        Stock outstanding immediately prior to such event.

    (c)          Cash Distributions. No adjustment on account of cash dividends or interest on the Company’s Series E‐1 Preferred Stock or other securities purchasable hereunder
        will be made to the purchase price under this Warrant.

    (d)          Authorized Shares. The Company covenants that during the period the Warrant is outstanding and exercisable, it will reserve from its authorized and unissued
        Series E‐1 Preferred Stock a sufficient number of shares to provide for the issuance of Series E‐1 Preferred Stock upon the exercise of any purchase rights under this Warrant. The Company further covenants that its issuance of this Warrant shall
        constitute full authority to its officers who are charged with the duty of executing stock certificates to execute and issue the necessary certificates for shares of the Company’s Series E‐1 Preferred Stock upon the exercise of the purchase rights
        under this Warrant.

    
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    10.          Miscellaneous.

    (a)          Issue Date. The provisions of this Warrant shall be construed and shall be given effect in all respects as if it had been issued and delivered by the Company on
        the date hereof. This Warrant shall be binding upon any successors or assigns of the Company. This Warrant shall be governed by and construed under the laws of the State of Delaware, without regard to the conflicts of laws provisions thereof.

    (b)          Restrictions. The holder hereof acknowledges that the Series E‐1 Preferred Stock acquired upon the exercise of this Warrant may have restrictions upon its resale
        imposed by state and federal securities laws or pursuant to Company contracts.

    (c)          Waivers and Amendments. With the consent of the Holders (as defined below) holding rights to purchase more than fifty percent (50%) of the shares issuable upon
        exercise of the then outstanding Warrants (as defined below), the obligations of the Company and the rights of the Holders may be waived (either generally or in a particular instance, either retroactively or prospectively and either for a specified
        period of time or indefinitely), and with the same consent the Company may enter into a supplementary agreement for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of the Warrants; provided,
        however, that no such waiver or supplemental agreement shall reduce the aforesaid percentage which is required for consent to any waiver or supplemental agreement, without the consent of all of the Holders of the then outstanding Warrants. As used
        in this paragraph 10(c), (i) “Warrants” shall mean the “Warrants” as issued pursuant to and defined in the Notes Amendment, and (ii) the “Holders” shall be the record holders of the Warrants.

    
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    IN WITNESS WHEREOF, CASTLE BIOSCIENCES, INC. has caused this Stock Purchase Warrant to be executed by its officer
      thereunto duly authorized as of the date first set forth above,

    
      	 	
              CASTLE BIOSCIENCES, INC.

            
	 	 	 
	 	
              By

            	 
	 	 	 
	 	
              Name: 

            
	 	
              Title: 

            

    

     

    
      	
              AGREED AND ACKNOWLEDGED:

            	 
	 	 	 
	
              [________________]

            	 

    

     

    
      	
              By:

            	   	 

    

      

    
      	
              Name:

            	 	 

    

     

    
      	
              Title:

            	 	 

    

     

    
      	
              Address:

            	 	 

    

     

    
      Castle Biosciences, Inc.

      Signature Page to Warrant

    

    
      
        
 

    

    NOTICE OF EXERCISE

     

    To:          CASTLE BIOSCIENCES, INC.

    (1)          The
        undersigned hereby elects to purchase ____________ shares of Series E-1 Preferred Stock of CASTLE BIOSCIENCES, INC. pursuant to the terms of the attached Warrant, and tenders herewith payment of the purchase price in full, together with all
        applicable transfer taxes, if any.

    (2)          Please
        issue a certificate of certificates representing said shares of Series E-1 Preferred Stock in the name of the undersigned or in such other name as is specified below:

    
      	 	 	 
	 	
              (Name)

            	 
	 	 	 
	 	 	 
	 	
              (Address)

            	 

    

    (3)          The undersigned represents that the aforesaid shares of Series E-1 Preferred Stock are being acquired for the account of the undersigned for investment and not with a view to, or
        for resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or reselling such shares.

    
      	
               

            	 	
               

            
	
              (Date) 

            	 	
              (Signature)

            

    

    
      
        
 

    

    

      

      ASSIGNMENT FORM

     

    (To assign the foregoing warrant, execute

      this form and supply required information.

      Do not use this form to purchase shares.)

    FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned to

    
      	
               

            
	
              (Please Print)

            
	
              whose address is  

            	
               

            
	  (Please Print)
	
               

               

            

      

      	
               

            	
               

            	
              Dated: _______________, 20 ____.

            

    

    
       

      	 	
              Holder’s Signature:

            	 

       

      	 	
              Holder’s Address:

            	 
	 	 	 
	 	 	 

       

      	 Signature Guaranteed:	 

    

    NOTE: The signature to this Assignment Form must correspond with the name as it appears on the face of the Warrant, without alteration or enlargement or any change whatever, and
      must be guaranteed by a bank or trust company. Officers of corporations and those acting in a fiduciary or other representative capacity should file proper evidence of authority to assign the foregoing Warrant.Exhibit 4.4

   

   

   

  THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE
    SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAWS OR, IN THE OPINION OF LEGAL
    COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

   

  
    	 	
            WARRANT TO PURCHASE STOCK

          
	 	 
	Company:	
            CASTLE BIOSCIENCES, INC.

          
	Number of Shares:	
            [______] shares of Series E-2 Preferred (the “Initial Shares”), plus all Additional Shares which Holder is entitled to purchase
              pursuant to Section 1.7

          
	Type/Series of Stock:	
            Series E-2 Preferred in the case of all Initial Shares or, in the case of all Additional Shares, Series E-3 Preferred

          
	Warrant Price:	
            $[_____] per share of Series E-2 Preferred in the case of the Initial Shares or, in the case of all Additional Shares, $[_____]
              per share of Series E-3 Preferred

          
	Issue Date:	
            [______________]

          
	Expiration Date:	
            [______________]; See also Section 5.1(b).

          
	Credit Facility:	
            This Warrant to Purchase Stock (“Warrant”) is issued in connection with that certain Loan and Security Agreement of even date herewith
              between [_____________] and the Company (the “Loan Agreement”).

          

  

   

   

  THIS WARRANT CERTIFIES THAT, for good and valuable consideration, [________________] (together with any successor or permitted assignee or
    transferee of this Warrant or of any shares issued upon exercise hereof, “Holder”) is entitled to purchase the number of fully paid and non-assessable shares (the “Shares”) of the above-stated Type/Series of Stock (the “Class”)

    of the above-named company (the “Company”) at the above-stated Warrant Price, all as set forth above and as adjusted pursuant to Section 2 of this Warrant, subject to the provisions and upon the terms and conditions set forth in this
    Warrant. Reference is made to Section 5.4 of this Warrant whereby [_____________] shall transfer this Warrant to its parent company, [_____________].

   

  SECTION 1  EXERCISE.

   

  1.1       Method of Exercise. Holder may at any time and from time to time exercise this Warrant, in whole or in part, by delivering to the
    Company the original of this Warrant together with a duly executed Notice of Exercise in substantially the form attached hereto as Appendix 1 and, unless Holder is exercising this Warrant pursuant to a cashless exercise set forth in Section 1.2, a
    check, wire transfer of same-day funds (to an account designated by the Company), or other form of payment acceptable to the Company for the aggregate Warrant Price for the Shares being purchased.

   

  
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  1.2       Cashless Exercise. On any exercise of this Warrant, in lieu of payment of the aggregate Warrant Price in the manner as specified
    in Section 1.1 above, but otherwise in accordance with the requirements of Section 1.1, Holder may elect to receive Shares equal to the value of this Warrant, or portion hereof as to which this Warrant is being exercised. Thereupon, the Company shall
    issue to the Holder such number of fully paid and non-assessable Shares as are computed using the following formula:

   

  X = Y(A-B)/A

   

  where:

   

  X = the number of Shares to be issued to the Holder;

   

  Y = the number of Shares with respect to which this Warrant is being exercised (inclusive of the Shares surrendered to the Company in
    payment of the aggregate Warrant Price);

   

  A = the Fair Market Value (as determined pursuant to Section 1.3 below) of one Share; and

   

  B = the Warrant Price.

   

  1.3       Fair Market Value.  If the Company’s common stock is then traded or quoted on a nationally recognized securities exchange,
    inter-dealer quotation system or over-the-counter market (a “Trading Market”) and the Class is common stock, the fair market value of a Share shall be the closing price or last sale price of a share of common stock reported for the
    Business Day immediately before the date on which Holder delivers this Warrant together with its Notice of Exercise to the Company. If the Company’s common stock is then traded in a Trading Market and the Class is a series of the Company’s convertible
    preferred stock, the fair market value of a Share shall be the closing price or last sale price of a share of the Company’s common stock reported for the Business Day immediately before the date on which Holder delivers this Warrant together with its
    Notice of Exercise to the Company multiplied by the number of shares of the Company’s common stock into which a Share is then convertible. If the Company’s common stock is not traded in a Trading Market, the Board of Directors of the Company shall
    determine the fair market value of a Share in its reasonable good faith judgment.

   

  1.4       Delivery of Certificate and New Warrant.  Within a reasonable time after Holder exercises this Warrant in the manner set forth in
    Section 1.1 or 1.2 above, the Company shall deliver to Holder a certificate representing the Shares issued to Holder upon such exercise and, if this Warrant has not been fully exercised and has not expired, a new warrant of like tenor representing the
    Shares not so acquired.

   

  1.5       Replacement of Warrant.  On receipt of evidence reasonably satisfactory to the Company of the loss, theft, destruction or
    mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form, substance and amount to the Company or, in the case of mutilation, on surrender of this Warrant to the
    Company for cancellation, the Company shall, within a reasonable time, execute and deliver to Holder, in lieu of this Warrant, a new warrant of like tenor and amount.

   

  1.6       Treatment of Warrant Upon Acquisition of Company.

   

  (a)       Acquisition.  For the purpose of this Warrant, “Acquisition”
      means any transaction or series of related transactions involving: (i) the sale, lease, exclusive license, or other disposition of all or substantially all of the assets of the Company (ii) any merger or consolidation of the Company into or with
      another person or entity (other than a merger or consolidation effected exclusively to change the Company’s domicile), or any other corporate reorganization, in which the stockholders of the Company in their capacity as such immediately prior to such
      merger, consolidation or reorganization, own less than a majority of the Company’s (or the surviving or successor entity’s) outstanding voting power immediately after such merger, consolidation or reorganization; or (iii) any sale or other transfer
      by the stockholders of the Company of shares representing at least a majority of the Company’s then-total outstanding combined voting power.

    

   

  
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  (b)       Treatment of Warrant at Acquisition.  In the event of an Acquisition in which the consideration to be received by the Company’s
    stockholders consists solely of cash, solely of Marketable Securities or a combination of cash and Marketable Securities (a “Cash/Public Acquisition”), and the fair market value of one Share as determined in accordance with Section 1.3
    above would be greater than the Warrant Price in effect on such date immediately prior to such Cash/Public Acquisition, and Holder has not exercised this Warrant pursuant to Section 1.1 above as to all Shares, then this Warrant shall automatically be
    deemed to be Cashless Exercised pursuant to Section 1.2 above as to all Shares effective immediately prior to and contingent upon the consummation of a Cash/Public Acquisition. In connection with such Cashless Exercise, Holder shall be deemed to have
    restated each of the representations and warranties in Section 4 of the Warrant as of the date thereof and the Company shall promptly notify the Holder of the number of Shares (or such other securities) issued upon exercise. In the event of a
    Cash/Public Acquisition where the fair market value of one Share as determined in accordance with Section 1.3 above would be less than the Warrant Price in effect immediately prior to such Cash/Public Acquisition, then this Warrant will expire
    immediately prior to the consummation of such Cash/Public Acquisition.

   

  (c)       Upon the closing of any Acquisition other than a Cash/Public Acquisition defined above, the acquiring, surviving or successor entity
    shall assume the obligations of this Warrant, and this Warrant shall thereafter be exercisable for the same securities and/or other property as would have been paid for the Shares issuable upon exercise of the unexercised portion of this Warrant as if
    such Shares were outstanding on and as of the closing of such Acquisition, subject to further adjustment from time to time in accordance with the provisions of this Warrant.

   

  (d)       As used in this Warrant, “Marketable Securities” means securities meeting all of the following requirements: (i) the
    issuer thereof is then subject to the reporting requirements of Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and is then current in its filing of all required reports and other
    information under the Act and the Exchange Act; (ii) the class and series of shares or other security of the issuer that would be received by Holder in connection with the Acquisition were Holder to exercise this Warrant on or prior to the closing
    thereof is then traded in Trading Market, and (iii) following the closing of such Acquisition, Holder would not be restricted from publicly re-selling all of the issuer’s shares and/or other securities that would be received by Holder in such
    Acquisition were Holder to exercise or convert this Warrant in full on or prior to the closing of such Acquisition, except to the extent that any such restriction (x) arises solely under federal or state securities laws, rules or regulations, and (y)
    does not extend beyond six (6) months from the closing of such Acquisition.

   

  1.7       Additional Shares.  Upon the funding of each Growth
      Capital Advance (as defined in the Loan Agreement) under the Second Tranche (as defined in the Loan Agreement), the Company shall be deemed to have automatically granted to Holder, in addition to the number of Shares which this Warrant can otherwise
      be exercised for by Holder, the right to purchase additional Shares consisting of the Company’s Series E-3 Preferred Stock in an amount equal to one and three-quarters of one percent (1.75%) of the amount of such Growth Capital Advance
    divided by $[_____], subject to adjustment as set forth in Section 2 below (collectively, such additional shares being called the “Additional Shares”).

   

  
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  SECTION 2  ADJUSTMENTS TO THE SHARES AND WARRANT PRICE.

   

  2.1       Stock Dividends, Splits, Etc.  If the Company declares or pays a dividend or distribution on the outstanding shares of the Class
    payable in common stock or other securities or property (other than cash), then upon exercise of this Warrant, for each Share acquired, Holder shall receive, without additional cost to Holder, the total number and kind of securities and property which
    Holder would have received had Holder owned the Shares of record as of the date the dividend or distribution occurred. If the Company subdivides the outstanding shares of the Class by reclassification or otherwise into a greater number of shares, the
    number of Shares purchasable hereunder shall be proportionately increased and the Warrant Price shall be proportionately decreased. If the outstanding shares of the Class are combined or consolidated, by reclassification or otherwise, into a lesser
    number of shares, the Warrant Price shall be proportionately increased and the number of Shares shall be proportionately decreased.

   

  2.2       Reclassification, Exchange, Combinations or Substitution.  Upon any event whereby all of the outstanding shares of the Class are
    reclassified, exchanged, combined, substituted, or replaced for, into, with or by Company securities of a different class and/or series, then from and after the consummation of such event, this Warrant will be exercisable for the number, class and
    series of Company securities that Holder would have received had the Shares been outstanding on and as of the consummation of such event, and subject to further adjustment thereafter from time to time in accordance with the provisions of this Warrant.
    The provisions of this Section 2.2 shall similarly apply to successive reclassifications, exchanges, combinations, substitutions, replacements or other similar events.

   

  2.3       Conversion of Preferred Stock. If the Class is a class and series of the Company’s convertible preferred stock, in the event that
    all outstanding shares of the Class are converted, automatically or by action of the holders thereof, into common stock pursuant to the provisions of the Company’s Certificate of Incorporation, including, without limitation, in connection with the
    Company’s initial, underwritten public offering and sale of its common stock pursuant to an effective registration statement under the Act (the “IPO”), then from and after the date on which all outstanding shares of the Class have been so
    converted, this Warrant shall be exercisable for such number of shares of common stock into which the Shares would have been converted had the Shares been outstanding on the date of such conversion, and the Warrant Price shall equal the Warrant Price
    in effect as of immediately prior to such conversion divided by the number of shares of common stock into which one Share would have been converted, all subject to further adjustment thereafter from time to time in accordance with the provisions of
    this Warrant.

   

  2.4       Adjustments for Diluting Issuances.  Without
      duplication of any adjustment otherwise provided for in this Section 2, the number of shares of common stock issuable upon conversion of the Shares shall be subject to anti-dilution adjustment from time to time in the manner set forth in the
      Company’s Certificate of Incorporation as if the Shares were issued and outstanding on and as of the date of any such required adjustment.

    

   

  
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  2.5       No Fractional Share. No fractional Share shall be issuable upon exercise of this Warrant and the number of Shares to be issued
    shall be rounded down to the nearest whole Share. If a fractional Share interest arises upon any exercise of the Warrant, the Company shall eliminate such fractional Share interest by paying Holder in cash the amount computed by multiplying the
    fractional interest by (i) the fair market value (as determined in accordance with Section 1.3 above) of a full Share, less (ii) the then-effective Warrant Price.

   

  2.6       Notice/Certificate as to Adjustments. Upon each adjustment of the Warrant Price, Class and/or number of Shares, the Company, at
    the Company’s expense, shall notify Holder in writing within a reasonable time setting forth the adjustments to the Warrant Price, Class and/or number of Shares and facts upon which such adjustment is based. The Company shall, upon written request from
    Holder, furnish Holder with a certificate of its Chief Financial Officer, including computations of such adjustment and the Warrant Price, Class and number of Shares in effect upon the date of such adjustment.

   

  SECTION 3  REPRESENTATIONS AND COVENANTS OF THE COMPANY.

   

  3.1       Representations and Warranties.  The Company represents and warrants to, and agrees with, the Holder as follows:

   

  (a)       The initial Warrant Price referenced on the first page of this Warrant is not greater than the price per share at which shares of the
    Class were last sold and issued prior to the Issue Date hereof in an arms-length transaction in which at least $500,000 of such shares were sold.

   

  (b)       All Shares which may be issued upon the exercise of this Warrant, and all securities, if any, issuable upon conversion of the Shares,
    shall, upon issuance, be duly authorized, validly issued, fully paid and non-assessable, and free of any liens and encumbrances except for restrictions on transfer provided for herein or under applicable federal and state securities laws. The Company
    covenants that it shall at all times cause to be reserved and kept available out of its authorized and unissued capital stock such number of shares of the Class, common stock and other securities as will be sufficient to permit the exercise in full of
    this Warrant and the conversion of the Shares into common stock or such other securities.

   

  (c)       The Company’s capitalization table as of the Issue Date is attached hereto as Schedule 1 and is true and complete, in all material
    respects, as of the Issue Date.

   

  3.2       Notice of Certain Events.  If the Company proposes at any time to:

   

  (a)       declare any dividend or distribution upon the outstanding shares of the Class or common stock, whether in cash, property, stock, or
    other securities and whether or not a regular cash dividend;

   

  (b)       offer for subscription or sale pro rata to the holders of the outstanding shares of the Class any additional shares of any class or
    series of the Company’s stock (other than pursuant to contractual pre-emptive rights);

   

  (c)       effect any reclassification, exchange, combination,
      substitution, reorganization or recapitalization of the outstanding shares of the Class;

    

   

  
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  (d)       effect an Acquisition or to liquidate, dissolve or wind up; or

   

  (e)       effect an IPO;

   

  then, in connection with each such event, the Company shall give Holder:

   

  (1)       at least seven (7) Business Days prior written notice of the date on which a record will be taken for such dividend,
    distribution, or subscription rights (and specifying the date on which the holders of outstanding shares of the Class will be entitled thereto) or for determining rights to vote, if any, in respect of the matters referred to in (a) and (b) above;

   

  (2)       in the case of the matters referred to in (c) and (d) above at least seven (7) Business Days prior written notice of the
    date when the same will take place (and specifying the date on which the holders of outstanding shares of the Class will be entitled to exchange their shares for the securities or other property deliverable upon the occurrence of such event and such
    reasonable information as Holder may reasonably require regarding the treatment of this Warrant in connection with such event giving rise to the notice); and

   

  (3)       with respect to the IPO, at least seven (7) Business Days prior written notice of the date on which the Company proposes to
    file its registration statement in connection therewith.

   

  Company will also provide information requested by Holder that is reasonably necessary to enable Holder to comply with Holder’s accounting or
    reporting requirements.

   

  SECTION 4  REPRESENTATIONS, WARRANTIES OF THE HOLDER. 

   

  The Holder represents and warrants to the Company as follows:

   

  4.1       Purchase for Own Account.  This Warrant and the securities to be acquired upon exercise of this Warrant by Holder, and any shares
    of common stock to be issued upon conversion of any such securities, are being acquired for investment for Holder’s account, not as a nominee or agent, and not with a view to the public resale or distribution within the meaning of the Act. Holder also
    represents that it has not been formed for the specific purpose of acquiring this Warrant or the Shares.

   

  4.2       Disclosure of Information.  Holder is aware of the Company’s business affairs and financial condition and has received or has had
    full access to all the information it considers necessary or appropriate to make an informed investment decision with respect to the acquisition of this Warrant and its underlying securities. Holder further has had an opportunity to ask questions and
    receive answers from the Company regarding the terms and conditions of the offering of this Warrant and its underlying securities and to obtain additional information (to the extent the Company possessed such information or could acquire it without
    unreasonable effort or expense) necessary to verify any information furnished to Holder or to which Holder has access.

   

  4.3       Investment Experience.  Holder understands that the
      purchase of this Warrant and its underlying securities involves substantial risk. Holder has experience as an investor in securities of companies in the development stage and acknowledges that Holder can bear the economic risk of such Holder’s

    investment in this Warrant and its underlying securities and has such knowledge and experience in financial or business matters that Holder is capable of evaluating the merits and risks of its investment in this Warrant and its underlying securities
    and/or has a preexisting personal or business relationship with the Company and certain of its officers, directors or controlling persons of a nature and duration that enables Holder to be aware of the character, business acumen and financial
    circumstances of such persons.

   

  
    6

    
      
 

  

  4.4       Accredited Investor Status.  Holder is an “accredited investor” within the meaning of Regulation D promulgated under the Act.

   

  4.5       The Act.  Holder understands that this Warrant and the Shares issuable upon exercise hereof have not been registered under the
    Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of the Holder’s investment intent as expressed herein. Holder understands that this Warrant and the Shares issued upon any
    exercise hereof must be held indefinitely unless subsequently registered under the Act and qualified under applicable state securities laws, or unless exemption from such registration and qualification are otherwise available. Holder is aware of the
    provisions of Rule 144 promulgated under the Act.

   

  4.6       Market Stand-off Agreement.  The Holder agrees that the Shares shall be subject to the Market Stand-Off provisions in Section
    2.10 of the Company’s Fourth Amended and Restated Investors’ Rights Agreement and any similar provision of any successor agreement, as if the Holder were a party thereto for the purposes of such section.

   

  4.7       No Voting Rights.  Holder, as a Holder of this Warrant, will not have any voting rights or any other rights as a stockholder of
    the Company (except to the extent provided herein) until the exercise of this Warrant.

   

  SECTION 5  MISCELLANEOUS. 

   

  5.1       Term and Automatic Conversion Upon Expiration.

   

  (a)       Term.  Subject to the provisions of Section 1.6 above, this Warrant is exercisable in whole or in part at any time and from time
    to time on or before 6:00 PM, Pacific time, on the Expiration Date and shall be void thereafter.

   

  (b)       Automatic Cashless Exercise upon Expiration.  In the event that, upon the Expiration Date, the fair market value of one Share (or
    other security issuable upon the exercise hereof) as determined in accordance with Section 1.3 above is greater than the Warrant Price in effect on such date, then this Warrant shall automatically be deemed on and as of such date to be exercised
    pursuant to Section 1.2 above as to all Shares (or such other securities) for which it shall not previously have been exercised, and the Company shall, within a reasonable time, deliver a certificate representing the Shares (or such other securities)
    issued upon such exercise to Holder.

   

  5.2       Legends.  The Shares (and the securities issuable, directly or indirectly, upon conversion of the Shares, if any) shall be
    imprinted with a legend in substantially the following form:

   

  THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
      UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN THAT CERTAIN WARRANT TO PURCHASE STOCK ISSUED BY THE ISSUER TO [_____________] DATED [_________________],
    MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER, SUCH OFFER, SALE, PLEDGE OR
    OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

   

  
    7

    
      
 

  

  5.3       Compliance with Securities Laws on Transfer.  This Warrant and the Shares issuable upon exercise of this Warrant (and the
    securities issuable, directly or indirectly, upon conversion of the Shares, if any) may not be transferred or assigned in whole or in part except in compliance with applicable federal and state securities laws by the transferor and the transferee
    (including, without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory to the Company, as reasonably requested by the Company). The Company shall not require Holder to provide an opinion of counsel
    if the transfer is to [_____________] ([_____________]’s parent company) or any other affiliate of Holder, provided that any such transferee is an “accredited investor” as defined in Regulation D promulgated under the Act. Additionally, the Company
    shall also not require an opinion of counsel if there is no material question as to the availability of Rule 144 promulgated under the Act.

   

  5.4       Transfer Procedure.  After receipt by [__________] of the executed Warrant, [__________] will transfer all of this Warrant to its
    parent company, [_____________]. By its acceptance of this Warrant, [_____________] hereby makes to the Company each of the representations and warranties set forth in Section 4 hereof and agrees to be bound by all of the terms and conditions of this
    Warrant as if the original Holder hereof. Subject to the provisions of Section 5.3 and upon providing the Company with written notice, [_____________] and any subsequent Holder may transfer all or part of this Warrant or the Shares issuable upon
    exercise of this Warrant (or the securities issuable directly or indirectly, upon conversion of the Shares, if any) to any transferee, provided, however, in connection with any such transfer, [_____________] or any subsequent Holder will give the
    Company notice of the portion of the Warrant being transferred with the name, address and taxpayer identification number of the transferee and Holder will surrender this Warrant to the Company for reissuance to the transferee(s) (and Holder if
    applicable); and provided further, that any subsequent transferee other than [_____________] shall agree in writing with the Company to be bound by all of the terms and conditions of this Warrant. Notwithstanding any contrary provision herein, at all
    times prior to the IPO, Holder may not, without the Company’s prior written consent, transfer this Warrant or any portion hereof, or any Shares issued upon any exercise hereof, or any shares or other securities issued upon any conversion of any Shares
    issued upon any exercise hereof, to any person or entity who or that directly competes with the Company, except in connection with an Acquisition of the Company by such a direct competitor.

   

  
    8

    
      
 

  

  5.5       Notices.  All notices and other communications
      hereunder from the Company to the Holder, or vice versa, shall be deemed delivered and effective (i) when given personally, (ii) on the third (3rd) Business Day after being mailed by first-class registered or certified mail, postage prepaid, (iii)
      upon actual receipt if given by facsimile or electronic mail and such receipt is confirmed in writing by the recipient, or (iv) on the first Business Day following delivery to a reliable overnight courier service, courier fee prepaid, in any case at
      such address as may have been furnished to the Company or Holder, as the case may be, in writing by the Company or such Holder from time to time in accordance with the provisions of this Section 5.5. All notices to Holder shall be addressed
    as follows until the Company receives notice of a change of address in connection with a transfer or otherwise:

   

  
    	 	 	 
	 	Attn:__________________	 
	 	 	 
	 	 	 
	 	Telephone:______________	 
	 	Facsimile:_______________	 
	 	Email address:___________	 

  

   

   

  Notice to the Company shall be addressed as follows until Holder receives notice of a change in address:

   

  	 	
          Castle Biosciences, Inc.

        	 
	 	
          Attn: Derek Maetzold

        	 
	 	
          2014 San Miguel Drive

        	 
	 	
          Friendswood, TX 77546

        	 

   

  5.6       Waiver.  This Warrant and any term hereof may be changed, waived, discharged or terminated (either generally or in a particular
    instance and either retroactively or prospectively) only by an instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought.

   

  5.7       Attorney’s Fees.  In the event of any dispute between the parties concerning the terms and provisions of this Warrant, the party
    prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorneys’ fees.

   

  5.8       Counterparts; Facsimile/Electronic Signatures.  This Warrant may be executed in counterparts, all of which together shall
    constitute one and the same agreement. Any signature page delivered electronically or by facsimile shall be binding to the same extent as an original signature page with regards to any agreement subject to the terms hereof or any amendment thereto.

   

  5.9       Governing Law.  This Warrant shall be governed by and construed in accordance with the laws of the State of California, without
    giving effect to its principles regarding conflicts of law.

   

  5.10      Headings.  The headings in this Warrant are for purposes of reference only and shall not limit or otherwise affect the meaning of
    any provision of this Warrant.

   

  
    9

    
      
 

  

  5.11      Business Days. “Business Day” is any day that is not a Saturday, Sunday or a day on which [_____________] is
    closed.

   

  [Remainder of page left blank intentionally]

   

  [Signature page follows]

  
    10

    
      
 

  

  IN WITNESS WHEREOF, the parties have caused this Warrant to Purchase Stock to be executed by their duly authorized representatives effective as
    of the Issue Date written above.

   

  “COMPANY”

   

  CASTLE BIOSCIENCES, INC.

   

  	 	 	 
	By:	 	 
	 	 	 
	Name: 	 	 
	 	 	 
	Title: 	 	 
	 	 	 
	 	(Print)	 

   

  “HOLDER”

   

  [______________________]

   

  	 	 	 
	By:	 	 
	 	 	 
	Name:	 	 
	 	 	 
	Title: 	 	 
	 	(Print)	 

   

   

   

  
    11

    
      
 

  

  
   

   

  APPENDIX 1

   

  NOTICE OF EXERCISE

   

  1.             The undersigned Holder hereby exercises its right purchase ______________ shares of the Common/Series _____________ Preferred
    [circle one] Stock of CASTLE BIOSCIENCES, INC. (the “Company”) in accordance with the attached Warrant To Purchase Stock, and tenders payment of the aggregate Warrant Price for such shares as follows:

   

  		[ ]	Check in the amount of $                payable to the order of the Company enclosed herewith

   

  		[ ]	Wire transfer of immediately available funds to the Company’s account

   

  		[ ]	Cashless Exercise pursuant to Section 1.2 of the Warrant

   

  		[ ] 	Other [Describe] _____________________________________________________________________

   

  2.             Please issue a certificate or certificates representing the Shares in the name specified below:

   

  	 	 	 
	 	 	Holder’s Name	 
	 	 	 
	 	
           

           

        	 
	 	
           

           

        	 
	 	 	(Address)	 

   

   

   

   

  3.             By its execution below and for the benefit of the Company, Holder hereby restates each of the representations and warranties in
    Section 4 of the Warrant to Purchase Stock as of the date hereof.

   

  
    	 	HOLDER:
	 	 	 
	 	 	 	 
	 	 	 
	 	 	 
	 	By:	 
	 	 	 
	 	Name:	 
	 	 	 
	 	Title:	 
	 	 	 
	 	(Date):	 

  

   

   

  
     Appendix 1

    
      
 

  

  
  SCHEDULE 1

   

  Company Capitalization Table

   

  See attached

   

    

  Schedule 1

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