Document:

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                                                                   Exhibit 10.15

                          STRATEGIC ALLIANCE AGREEMENT

         This Strategic Alliance Agreement ("Agreement") is made and entered
into as of October 2, 2001 by and between Bruker AXS Inc., a Delaware
corporation with its principal place of business in Madison, Wisconsin
("BAXS") and GeneFormatics Incorporated, a California corporation with its
principal place of business in San Diego, California ("GFI").

                                   WITNESSETH:

         WHEREAS, GFI is a leading structural proteomics company which intends
to conduct a round of financing with respect to GFI's Series C Preferred Stock
("Series C Financing") and to purchase from BAXS X-ray single crystal
diffraction ("XSCD") systems and related equipment ("XSCD Products");

         WHEREAS, BAXS is a leading XSCD company which desires to (i) sell to
GFI XSCD Products and to provide certain support and maintenance services
relating thereto, and (ii) make a One Million Dollar ($1,000,000) investment
in GFI as part of the Series C Financing ("BAXS Investment"); and

         WHEREAS, the parties desire to work together with respect to XSCD for
structural proteomics;

         NOW, THEREFORE, in consideration of the foregoing and the mutual
covenants contained herein, the parties hereto hereby agree as follows:

         1.0 TECHNOLOGICAL COLLABORATION

         The parties shall work together in the following areas as may be
mutually agreed from time to time:

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS
EXHIBIT, WHICH PORTIONS HAVE BEEN OMITTED AND REPLACED WITH [**] AND FILED
SEPARATELY WITH THE COMMISSION.

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             1.1 GFI shall make a material investment in XSCD. GFI is in the
process of developing a specific XSCD strategy in conjunction with Tony
Kossiakoff, Ph.D., a world class XSCD scientist at the University of Chicago
and an exclusive consultant to GFI in the fields of structural genomics and
structural proteomics.

             1.2 In conjunction with developing such strategy, GFI shall work
with BAXS to incorporate BAXS' capabilities into such strategy. This shall
include, among other items, the following:

                 1.2.1 It is anticipated that GFI will initially [**]from
BAXS.

                 1.2.2 It is anticipated that, as part of a second phase, GFI
may expand its technology platforms for protein structure and function
discovery by [**].

             1.3 The XSCD lab at GFI may serve as a test site for future
capabilities.

             1.4 GFI may provide BAXS access to GFI's experimental protocols and
methods for automated crystallization and sample purification and preparation.

         2.0 INVESTMENT

             GFI intends to undergo a Series C Financing during the calendar
year 2001. BAXS shall make the BAXS Investment in cash and stock as part of
the Series C Financing; provided, however, that such investment is required
to be made by BAXS only if GFI closes the Series C Financing during the 2001
calendar year and GFI receives at least [**] in such Series C Financing
(including the BAXS Investment and the investments of any affiliates of
BAXS). The BAXS

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

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Investment shall be comprised of $500,000 of cash and $500,000 of BAXS stock.
The BAXS stock shall be valued at (a) if the Series C Financing closes prior
to September 15, 2001, $7.00 per share; and (b) if the Series C Financing
closes after September 15, 2001, (i) the fair market value thereof as
determined by the BAXS Board of Directors in agreement with GFI if the
initial public offering of BAXS has not yet been declared effective, or (ii)
the average closing price over the ten (10) NASDAQ trading days ending three
(3) days prior to the closing date of the Series C Financing, if the initial
public offering of BAXS has been declared effective. BAXS' completion of the
BAXS Investment is subject to the following:

             2.1 BAXS shall invest at a valuation and on terms and conditions no
less favorable than those provided to any other investor in GFI's Series C
Preferred Stock.

             2.2 If such Series C Financing is not closed on or before December
31, 2001, this Section 2.0 shall be of no further force or effect.

         3.0 SALE AND PURCHASE OF XSCD PRODUCTS

             Subject to closing of the BAXS Investment, GFI may from time to
time submit purchase orders for XSCD Products.

         4.0 PREFERRED CUSTOMER STATUS

             Given the parties' desire to create a strategic alliance
hereunder, BAXS shall sell XSCD Products and support to GFI at [**] prices,
terms, and other conditions; provided, however, GFI acknowledges that this
also has to be a win-win situation for BAXS, and that BAXS needs to receive
its [**] margins on any purchases of XSCD Products and support by GFI.

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

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         5.0 EXPENSES

             Each party shall be responsible for its own expenses in connection
with the execution of, and performance under, this Agreement.

         6.0 EXCLUSIVITY

             Subject to the terms and conditions contained herein and except for
XSCD Products not offered by BAXS, for the term of this Agreement, including any
extension thereof, BAXS shall be the sole and exclusive supplier of XSCD
Products to GFI.

         7.0 TERM

             7.1 The term of this Agreement shall commence as of the date of
this Agreement and continue for three (3) years thereafter, unless terminated
earlier as set forth herein. Upon mutual written agreement of the parties
prior to each expiration date, the term of this Agreement may be extended for
a series of successive two (2) year periods.

             7.2 Either party may terminate this Agreement effective immediately
and without liability upon written notice to the other party if any one of the
following events occurs: (a) the other party files a voluntary petition in
bankruptcy or otherwise seeks protection under any law for the protection of
debtors; (b) a proceeding is instituted against the other party under any
provision of the Federal Bankruptcy Code or equivalent legislation of a foreign
jurisdiction which is not dismissed within ninety (90) days; (c) the other party
is adjudicated bankrupt; (d) a court assumes jurisdiction of the assets of the
other party under a federal reorganization act or equivalent legislation of a
foreign jurisdiction; (e) a trustee or receiver is appointed by a court for all
or a substantial portion of the assets of the other party; (f) the other party
becomes insolvent, ceases or suspends

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

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business; (g) the other party makes an assignment of the majority of its assets
for the benefit of its creditors, or (h) the BAXS Investment is not made in
calendar year 2001.

             7.3 Either party may terminate this Agreement effective
immediately and without liability upon written notice to the other party if a
party breaches a material obligation hereunder and does not cure such breach
within [**] after receiving notice of such breach from the other party.

             7.4 The provisions of Sections 5, 7.4, 8, 10 and 11 shall survive
termination or expiration of this Agreement.

         8.0 CONFIDENTIALITY

             Each party shall itself, and shall cause its employees to, keep
confidential and refrain from using, except to the extent necessary to perform
the obligations set forth under this Agreement, all technology and all
confidential business and technical information disclosed to such party by the
other party. The foregoing shall not apply to such information that a party can
demonstrate (i) was known to such party before it was disclosed to such party,
(ii) was known to the public at the time of disclosure, or subsequently becomes
so known through no act or omission of such party, (iii) is received by such
party from a third party not under any obligation of confidentiality, (iv) is
owned by such party or (v) is developed by such party independently of any
disclosure hereunder. A party shall disclose such confidential information of
the other party only to those of its employees having a need to know and who
have agreed to be bound by duties of confidentiality no less protective than
those contained herein.

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

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         9.0 PUBLICITY

             Promptly upon the execution of this Agreement, the parties shall
issue a mutually agreeable joint press release which shall refer to the parties'
strategic relationship and BAXS' equity investment in GFI.

         10.0 OWNERSHIP

              10.1 This Agreement shall not give either party any ownership
interest in or rights to the patent rights, copyrights, trade secrets or any
other intellectual property rights ("IP Rights") of the other party, and all IP
Rights that are owned or controlled by a party at the commencement of this
Agreement shall remain under the ownership or control of such party.

              10.2 Each party shall own the entire right, title and interest in
any inventions, discoveries, improvements, works of authorship, computer
software, algorithms, or the like it may invent, make, author, or otherwise
develop under or in connection with this Agreement, including all IP Rights
relating thereto. Such party shall have the sole authority to determine what
intellectual property protection, if any, it desires to seek for such items.

              10.3 The parties [**] all inventions, discoveries,
improvements, works of authorship, computer software, algorithms, or the like
they [**] invent, make, author, or otherwise develop under or in connection
with this Agreement, and shall [**].

         11.0 MISCELLANEOUS PROVISIONS

              11.1 This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware.

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

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              11.2 Nothing contained herein shall be construed as constituting a
joint venture, partnership or other form of business organization. The parties
have entered into this Agreement solely as independent contractors, and neither
party shall have any authority to bind or commit the other party.

              11.3 All notices given hereunder shall be in writing, sent by
certified mail, return receipt requested, addressed as follows, provided that a
party may change its address for notices by notice thereof:

                  If to BAXS:     Bruker AXS Inc.
                                  5465 E. Cheryl Parkway
                                  Madison, WI 53711
                                  Attn.:  President

                  If to GFI:      GeneFormatics Incorporated
                                  5830 Oberlin Drive, Suite 200
                                  San Diego, CA 92121-3754
                                  Attn.:  President and Chief Executive Officer

              11.4 This Agreement shall be binding upon and inure to the benefit
of the parties hereto and their respective successors and assigns.

              11.5 This Agreement constitutes the entire agreement between the
parties concerning its subject matter and supersedes any prior or
contemporaneous agreements and understandings in connection therewith,
including, without limitation, that certain Non-Binding Letter of Intent for
Strategic Partnership in Structural Proteomics by and among GFI, BAXS and
certain affiliates of BAXS. This Agreement may be amended or waived only by a
written instrument executed by both parties.

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         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first written above.

GENEFORMATICS INCORPORATED                 BRUKER AXS INC.

By: /s/ John P. Schmid                     By: /s/ Martin Haase
   --------------------------                  -------------------------------

Title: Chief Financial Officer             Title: President and
      -----------------------                       Chief Executive Officer
                                                  ----------------------------

                                       8<PAGE>

                                                                 Exhibit 10.17

LEASE AGREEMENT FOR OFFICE SPACE
AND OTHER CORPORATE SPACE NOT PURSUANT TO ARTICLE 7A:1624 OF THE CIVIL CODE
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in accordance with the model established in February 1996 by the Real Estate
Council.
         Reference to this model is permitted only if the filled out, added or
modified text is clearly recognizable as such. Additions and modifications
should preferably be included under the heading "Special Provisions." The
Council precludes liability for any adverse consequences of using the text of
the model.

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The undersigned, Van Haaren Beheer B.V., registered in the Delft Office of the
Chamber of Commerce of Haaglanden under Commercial Register Number 27215913,
based in 2627 AN Delft at Schieweg 25, legally represented in this matter by P.
T. van Haaren, holder of passport No. N97117176, hereinafter to be called
Lessor,

and

Bruker Nonius B.V., registered in the Delft Office of the Chamber of Commerce of
Haaglanden under Commercial Register Number 27230375, based at Rontgenweg 1 in
2624 BD Delft, legally represented in this matter by L. V. Boskma, holder of
passport No. N74818495, hereinafter to be called Lessee,

Agree to the following:

LEASED PREMISES, PURPOSE, USE

1.1 This Lease Agreement shall relate to the corporate space, hereinafter to be
called Leased Premises, which is locally known as Oostsingel 209 and
Surinamestraat 2 in Delft and which is more specifically indicated in the
drawing and/or description of Leased Premises, which has been certified by the
parties and attached to this Deed and which constitutes a part of this Lease
Agreement. Land Registry Record.: Delft sectio N, Nos. 2517, 2701, 3036 n 3165,
together constituting a surface of 59 ares and 35 centiares.

1.2 Leased Premises may be used exclusively as an office and production area
workshop [for] instrument factory, with showroom and cafeteria with kitchen for
the company's own use. On the interior terrain, there are some additional
facilities, such as container area, explosives shed and bicycle parking rack. In
the yard, there is room for car parking places.
         The complex to be leased is part of an industrial area intended
according to plan to become an "Indonesian neighborhood." According to
information from the municipality of Delft, the corporate activity planned by
Lessee does not conflict with this plan.

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1.3 Lessee shall not be allowed to use Leased Premises for any purpose other
than that described in 1.2, without previous written consent from Lessor.

1.4 The maximum allowable load on the floor(s) of Leased Premises is sufficient
for the activities referred to above. Floor load on the above-ground floors
amounts to approximately 700 kg.

TERMS AND CONDITIONS

2.1 The General Provisions of the Lease Agreement for Office Space
and Other Corporate Space Not Pursuant to Article 7A:1624 of the Civil Code,
filed on February 29, 1996, with the Clerk of the Court at the Court in The
Hague and recorded there under Number 34/1996, hereinafter to be called "General
Provisions," shall be a part of this Agreement. The contents of these General
Provisions is known to the parties and Lessee has received a copy.

2.2 The Provisions referred to in 2.1 shall apply, except where a deviation
therefrom is explicitly indicated in this Agreement or where application of
these Provisions is not possible with respect to Leased Premises.

TERM, RENEWAL AND TERMINATION

3.1 This Agreement has been concluded for a term of six years with an automatic
renewal to ten years, becoming effective as of November 1, 2001, and lasting
through October 31, 2011, unless Lessee gives notice before November 1, 2006, in
accordance with Article 3.4, for a termination of the lease on October 31, 2007.

3.2 Upon expiration of the period referred to in 3.1, this Agreement shall be
continued for a contiguous ten-year period, that is, through October 31, 2021.

3.3 This Agreement shall be discontinued by means of a notice of termination, to
be submitted shortly before the end of a lease period and observing a term of
notice of at least one year.

3.4 Termination must take place by means of a writ of summons or by registered
letter.

3.5 Interim discontinuance of this Agreement shall be possible in a circumstance
such as described in 7 of the General Provisions.

                                                                  [2 initials]

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PAYMENT OBLIGATION, TERM OF PAYMENT

4.1 Lessee's payment obligation shall consist of:
- The lease price
- The compensation for incidental deliveries and services, including the sales
  taxes owed on these
- The sales tax owed on the lease price, or a corresponding amount, in
  accordance and in compliance with 15.2 and 15.3 of the General Provisions,
  in cases where parties have agreed upon a lease price subject to sales tax.

4.2 The lease price shall amount to NLG 900,000.00, that is, nine hundred
thousand guilders (Euro 408,402), plus V.A.T., on an annual basis.

4.3 The lease price shall be adjusted for the first time on November 1, 2002,
and then annually on November 1, in accordance with 4.1 through 4.2 of the
General Provisions.

4.4 The compensation for incidental deliveries and services shall be determined
in accordance with 12 of the General Provisions. A system of advance payments
with settlement at a later date shall be applied to this compensation, as set
forth there.

4.5 The payments to be made to Lessor by Lessee shall be due in lump sum advance
payments during contiguous payment periods, as stipulated in 4.6. They must be
paid in full before, or on the first day of, the period to which the payments
relate.

4.6 The following amounts shall apply per payment period of one calendar month
for the following payment obligations:
-        Lease price                           NLG 75,000.00 (Euro 34,033.50)
-        Advance on compensation for
         incidental deliveries and
         services provided by or on
         behalf of Lessor                      NLG      not applicable
-        Sales taxes of 19%                    NLG 14,250.00 (Euro  6,466.37)
                                               ==============================
Total                                          NLG 89,250.00 (Euro 40,499.87),

that is, eighty-nine thousand two hundred fifty guilders.
These amounts include sales taxes.

4.7 In view of the effective date of the lease, the first payment period shall
be for November 2001, and the amount owed for this first period shall be NLG
89,250.00 (Euro 40,499.87), including sales taxes. Lessee shall pay this amount,
including any sales taxes owed on it, on or before October 19, 2001.

SALES TAXES

5.1 All amounts listed in this Agreement are exclusive of sales taxes. Lessee
shall owe sales taxes on the compensation for incidental deliveries and
services. In the case of a lease subject

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to sales tax, this shall apply to the lease price as well. The sales taxes shall
be invoiced by Lessor and they must be paid together with the lease price and
the compensation for incidental deliveries and services, or the advance on
these.

5.2 The parties shall agree that Lessor shall invoice Lessee for sales taxes on
the lease price.

5.3 If it has been agreed that sales taxes on the lease price will be invoiced,
Lessee shall hereby grant Lessor and his legal successor(s) an irrevocable power
of attorney to submit an application as intended in Article 11, Section 1, Item
b, Point 5, of the 1968 Act on Sales Taxes (option application for leases
subject to taxes), also on his behalf. If requested, Lessee shall co-sign such
an application within 14 days after having received it with this request from
Lessor and return it to Lessor. Lessee shall hereby state that the work
activities in Leased Premises are subject to V.A.T., pursuant to the Act on
Sales Taxes, at a minimum of 90%. Lessee's fiscal year shall run from January 1
through December 31.

DELIVERIES AND SERVICES

6 The parties shall agree that incidental deliveries and services to be provided
by or on behalf of Lessor shall be Not Applicable.

BANK GUARANTY
The amount of the bank guaranty stipulated in 8.1 of the General Provisions
shall amount to NLG 267,750.00, that is, two hundred sixty-seven thousand seven
hundred fifty guilders (Euro 121,499.65).

MANAGER

8. Mr. M. Neuteboom shall act as manager until such time as Lessor will make a
decision to the contrary. He shall be reachable by telephone at 015-261-2321 or
at 06-5107-5480 on his cell phone.

9. SPECIAL PROVISIONS

-        In the case of a sale during the term of the Agreement, Lessee shall
         have the right of first purchase at a daily value to be determined at
         the appropriate time. The right of first purchase to the benefit of
         Lessee shall explicitly not apply in cases of transfer of property to
         "van Haaren affiliated companies and/or family members and/or persons
         to whom

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                                                                  [2 initials]

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         a partnership agreement applies." Determination of the daily value
         shall be obtained by 1) mutual agreement between Lessee and Lessor, 2)
         appraisal by two certified brokers/appraisers of real estate and,
         possibly, 3) an authority to be appointed by the Justice of the Peace
         of Delft, which shall submit a binding opinion.

-        During the term of the Agreement, Lessee shall be entitled to sublet to
         third parties. When the Agreement is discontinued on October 31, 2021,
         or on whichever subsequent date is agreed, Leased Premises shall be
         delivered by Lessee to Lessor or his legal successor(s) empty and free
         of lease or any other obligations for use. In cases of actual sublet,
         Lessor shall receive a copy of the sublet agreement.

-        Lessee shall be responsible for the necessary permits and for any
         adjustments for environmental reasons.

-        Lessee has been given correspondence regarding the installation (Kone
         contract), and Geveke mechanical engineering relating to the
         refrigerator with R22 refrigerant, which is located in Leased Premises
         and which should be removed.

-        Upon signing of this Lease Agreement, Eneco Energie shall be informed
         by Lessee about the change in the user's agreement. Lessee shall
         request new delivery as of October 12, 2001. Correspondence from Eneco
         regarding meters that are to be replaced shall serve as an enclosure in
         this matter.

-        The structures present on the land, including any glass, have been
         insured by Lessor.

Thus executed and signed in duplicate in Delft on October 12, 2001.

P. T. van Haaren                                              L. W. Boskma
[signature]                                                   [signature]
(Lessor)                                                      (Lessee)

Enclosures:
-        The General Provisions
-        Drawing of Leased Premises
-        The Bank Guaranty as referred to in 7
-        Description of Leased Premises
-        Report C00-247.o, dated May 2000, by Arnicon B.V. (soil)
-        Statement of Affairs for asbestos in accordance with BRL 5052, dated
         5/22/00, by Search Milieu B.V.
-        Drawing of TNO workshop at ground level, dated April 2001, with
         indication of remainders of colo-vinyl tiles present under system
         walls
-        Listing of systems installed and of inventory sold once by Lessor
-        Agreement regarding financial compensation to Lessee for

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         improvements of the premises in case of departure before October 31,
         2021.

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                                                                  [2 initials]

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                          ACKNOWLEDGMENT OF TRANSLATION

                                 November 8, 2001

         The undersigned officer of the Registrant hereby acknowledges on
behalf of the Registrant that the foregoing translation of the Lease
Agreement for office space between Bruker Nonius B.V. and Van Haaren Beheer
B.V. is a fair and accurate English translation from Dutch of the
original executed agreement.

                                       BRUKER AXS INC.

                                       By: /s/ Lieuwe Boskma
                                           -----------------------
                                           Lieuwe Boskma, Managing
                                           Director, Bruker Nonius B.V.

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