Document:

Asset Purchase Agreement

 Exhibit 10.25 
 ASSET PURCHASE AGREEMENT 
 This Asset Purchase Agreement
(“Agreement”) is entered into as of November 30, 2011 (“Effective Date”) by and between SA Pathology, a unit of Central Adelaide Local Health Network Inc, incorporated under the Health Care Act of 2008, having
its principal place of business at Frome Road, Adelaide, South Australia, Australia (“SA Pathology”) and BMRN Bears Ltd., an Irish corporation resident in The Bahamas having its principle place of business at 60 Montrose Ave,
Nassau, Bahamas (“BioMarin”) (each of the above companies also referred to individually as “Party” and collectively as “Parties”). 

RECITALS 

WHEREAS, SA Pathology and BioMarin’s Affiliate, BioMarin Pharmaceutical Inc., (“BPI”) have entered into a
License Agreement dated February 7, 2007 (“License Agreement”) relating to certain intellectual property related to N-acetylgalactosamine-4-sulfatase whereby BioMarin was granted an exclusive license to such intellectual
property, referred to herein as the Transferred Assets; and 
 WHEREAS, SA Pathology is the exclusive owner of the
Transferred Assets; and 
 WHEREAS, BioMarin desires to acquire from SA Pathology, and SA Pathology desires to assign to
BioMarin, the Transferred Assets subject to and in accordance with the provisions of this Agreement. 
 NOW, THEREFORE,
in consideration of the mutual covenants and promises contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, SA Pathology and BioMarin agree as follows: 

 

	1.	Definitions. In addition to the terms defined elsewhere in this agreement, the following terms shall have the following meanings: 

 

	 	1.1.	“Affiliate” of a Party means any person or entity that directly or indirectly controls, is controlled by, or is under common control with such Party,
where “control” means if a Party: (a) owns, directly or indirectly, fifty percent (50%) or more of (i) the voting stock or shareholders’ equity of a corporation, (ii) the partnership interests in a partnership, or
(iii) the membership interests in a limited liability company; or (b) possesses, directly or indirectly, the power to direct or cause the direction of the management and policies of the entity or person or the power to elect more than
fifty percent (50%) of the members of the governing body of the entity; 

  

	 	1.2.	“Law” means any local, state, or national rule, regulation, statute or law, or governmental agency regulation, in any jurisdiction relevant to the
activities undertaken pursuant to this Agreement, the Transferred Assets, or applicable to either of the Parties with respect to any matters set forth herein; 

 

	 	1.3.	“Patent” shall mean the rights and interests in and to issued patents and pending patent applications in any country, including, without limitation,
all provisional applications, substitutions, continuations, continuations-in-part, divisionals and renewals, all letters patent granted thereon, if any, and all reissues, re-examinations, re-registrations and extensions thereof, and supplemental
protection certificates of invention and utility models; 

  
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	 	1.4.	“Transferred Assets” means Transferred Patents and Transferred Know-How; 

 

	 	1.5.	“Transferred Know-How” means all “Licensed Technology” as such term is used in the License Agreement, other than the Transferred Patents; and

  

	 	1.6.	“Transferred Patents” means all Patents included with the “Licensed Technology” as such term is used in the License Agreement, including,
without limitation, those Patents listed on Exhibit A. 

  

	2.	Construction and Interpretation. 

  

	 	2.1.	The Section headings in this Agreement are for convenience of reference only, will not be deemed to be a part of this Agreement, and will not be referred to in
connection with the construction or interpretation of this Agreement. All references in this Agreement to “Sections” are intended to refer to Sections of this Agreement. 

 

	 	2.2.	Any rule of construction to the effect that ambiguities are to be resolved against the drafting Party will not be applied in the construction or interpretation of this
Agreement. 

  

	 	2.3.	As used in this Agreement, the words “include” and “including” and variations thereof, will not be deemed to be terms of limitation, but rather will
be deemed to be followed by the words “without limitation”. 

  

	 	2.4.	The Exhibits form part of this Agreement and shall have effect as if set out in full in the body of this Agreement. Any reference to this Agreement includes the
Exhibits. 

  

	 	2.5.	Save where the contrary is indicated, any reference in this Agreement to: 

  

	 	2.5.1.	words importing the singular shall include the plural and vice versa; 

  

	 	2.5.2.	any reference to a “person” includes any individual, company, corporation, unincorporated association or body (including a partnership, trust, fund, joint
venture or consortium), government, state, agency, organisation or other entity whether or not having separate legal personality; 

  

	 	2.5.3.	any person (including the Parties) shall be construed so as to include its and any subsequent successors, transferees and assigns in accordance with their respective
interests; 

  

	 	2.5.4.	this Agreement or any other agreement or document shall be construed as a reference to this Agreement or, as the case may be, such other agreement or document as the
same may have been, or may from time to time be, amended, varied, novated, replaced or supplemented; and 

  
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	 	2.5.5.	a provision of law (including Law generally) is a reference to that provision as extended, applied, amended or re-enacted and includes any subordinate legislation.

  

	3.	Assignment of Transferred Assets. 

  

	 	3.1.	Subject to the terms and conditions of this Agreement, SA Pathology hereby sells, assigns, transfers, conveys and delivers to BioMarin, and BioMarin hereby purchases,
accepts and acquires from SA Pathology, all right, title and interest in, to and under the Transferred Assets. On the Effective Date, SA Pathology shall execute and deliver the Patent Assignment attached hereto as Exhibit B.

  

	 	3.2.	BioMarin does not assume, shall not take subject to and shall not be liable for, any liabilities or obligations of any kind or nature, whether absolute, contingent,
accrued, known or unknown, of SA Pathology or any Affiliate of SA Pathology related to the ownership of the Transferred Assets prior to the Effective Date. To this extent, SA Pathology shall remain liable for all payments (if any) related to the
ownership of the Transferred Assets up to and as of the Effective Date. 

  

	 	3.3.	At closing BioMarin shall assume, shall take and shall be liable for, any liabilities or obligations of any kind or nature, whether absolute or contingent, related to
the ownership of the Transferred Assets after the Effective Date. 

  

	 	3.4.	Neither Party shall have any implied rights or implied obligations in connection with this Agreement. Rather, each Party’s rights and obligations shall be solely
as expressly set forth in this Agreement. 

  

	 	3.5.	SA Pathology hereby assigns the License Agreement to BioMarin, provided that as a condition to executing this Agreement, BPI shall execute the acknowledgement attached
hereto as Exhibit C. BioMarin hereby guarantees BPI’s obligations under such acknowledgement. 

  

	 	3.6.	Further Assurances. SA Pathology agrees to complete and execute such additional transfer documentation, and to take such additional actions, at no cost to BioMarin, to
give effect to transfer and assignment described in this Section 3. 

  

	4.	Consideration. In consideration for the assignment to BioMarin described in Section 3, BioMarin shall pay SA Pathology by wire transfer to the
account specified on Exhibit D the sum of Eighty One Million United States Dollars (US$81,000,000). All amounts required to be paid to SA Pathology pursuant to this Agreement shall be made free and clear of any taxes, duties, levies, fees or
charges. 

  

	5.	Confidentiality. 

  

	 	5.1.	Confidential Information Defined. Confidential Information means all information embodied in the Transferred Assets other than information which:
(i) becomes part of the public domain without the fault of SA Pathology; (ii) is rightfully obtained by the SA Pathology from a third party with the right to transfer such information without obligation of confidentiality.

  
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	 	5.2.	Maintenance of Confidential Information. SA Pathology agrees that SA Pathology will take measures to maintain the confidentiality of the Confidential Information
equivalent to those measures SA Pathology uses to maintain the confidentiality of its own confidential information of like importance but in no event less than reasonable measures and shall not use any Confidential Information other than in the
furtherance of this Agreement. SA Pathology will give immediate notice to BioMarin of any unauthorized use or disclosure of the Confidential Information that comes to the attention of SA Pathology and agrees to assist BioMarin in remedying such
unauthorized use or disclosure. SA Pathology may disclose Confidential Information as may be required by law, a court order, or a governmental agency with jurisdiction, provided that before making such a disclosure SA Pathology first notifies
BioMarin promptly and in writing and cooperates with BioMarin, at BioMarin’s reasonable request and expense, in any lawful action to contest or limit the scope of such required disclosure. 

 

	6.	Mutual Representations and Warranties. Each Party represents and warrants to the other that: 

 

	 	6.1.	it is a corporation, duly incorporated and validly existing under the law of its jurisdiction of incorporation; 

 

	 	6.2.	it has full right, power, and authority to enter into this Agreement and to perform its obligations and duties under this Agreement; 

 

	 	6.3.	it has obtained all authorizations required or desirable: 

  

	 	6.3.1.	to enable it to lawfully enter into, exercise its rights and comply with its obligations in this Agreement; and 

 

	 	6.3.2.	to make this Agreement admissible in evidence in its jurisdiction of incorporation; and 

 

	 	6.4.	the entry into and performance by it of, and the transactions contemplated by, this Agreement do not and will not conflict with: 

 

	 	6.4.1.	any law or regulation applicable to it; 

  

	 	6.4.2.	any agreement or instrument binding upon it. 

  

	7.	Representations and Warranties By SA Pathology. SA Pathology represents and warrants: 

 

	 	7.1.	on the Effective Date, that it has full right, power, and authority to assign the Transferred Assets to BioMarin in accordance with the terms of this Agreement and SA
Pathology or its Affiliates have not entered into any inconsistent or conflicting arrangement, or granted any inconsistent or conflicting rights or exclusivity; 

  
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	 	7.2.	on the Effective Date, that if based on an invention made by an employee of SA Pathology, Transferred Assets have been effectively, unconditionally, irrevocably and
fully transferred to SA Pathology pursuant to the Law; 

  

	 	7.3.	on the Effective Date, that it has not granted any security interest, option, lien, license, or encumbrance of any nature with respect to any Transferred Patent or
Transferred Know-How; 

  

	 	7.4.	the Transferred Assets include all of the Licensed Technology, as defined in the License Agreement, as of the Effective Date and, to SA Pathology’s knowledge there
is no additional intellectual property in development by SA Pathology of its Affiliates that is or is likely to be automatically included within the Licensed Technology pursuant to the terms of the License Agreement 

 

	 	7.5.	on the Effective Date, that it has not received at any time written notice from any third party alleging that BPI’s practice of the Transferred Assets infringes
the intellectual property rights of that third party; and 

  

	 	7.6.	on the Effective Date, that, to SA Pathology’s knowledge, no court, patent office or other proceeding is pending or threatened, nor has any written claim been
received by SA Pathology, which challenges or challenged the legality, validity, or enforceability of the Transferred Patents or any of them. 

  

	8.	Disclaimer. Except as provided above, neither Party makes any representations, extends any warranties of any kind, assumes any responsibility or obligations
whatsoever, or confers any right by implication, estoppel, or otherwise, other than the licenses, rights, and warranties expressly granted herein. 

  

	9.	General. 

  

	 	9.1.	Governing Law. This Agreement will be construed in accordance with and governed in all respects by the laws of England and Wales. 

 

	 	9.2.	Waiver. The waiver by either Party of a breach of a default of any provision of this Agreement by the other Party shall not be construed as a waiver of any
succeeding breach of the same or any other provision, nor shall any delay or omission on the part of either Party to exercise or avail itself of any right, power or privilege that it has or may have hereunder operate as a waiver of any right, power
or privilege by such Party. 

  

	 	9.3.	Notices. Any notice or other communication in connection with this Agreement must be in writing and shall be effective when delivered to the addressee at the
address listed below or such other address as the addressee shall have specified in a notice actually received by the addressor. 

  
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 If to SA PATHOLOGY: 

Berg Lawyers 

89 King William Street 
 Adelaide, SA 5000 
 Australia 

ATTN: Shaun Berg 
 If to BioMarin: 
 BMRN Bears Ltd. 

60 Montrose St. 

Nassau, NP 

The Bahamas 

ATTN: Managing Director 
 With a copy to: 
 BioMarin Pharmaceutical Inc. 

105 Digital Drive 
 Novato, California 94949 
 ATTN: General Counsel 

 

	 	9.4.	Entire Agreement. This Agreement contains the full understanding of the Parties with respect to the subject matter hereof and supersedes all prior understandings
and writings relating thereto. No waiver, alteration or modifications of any of the provisions hereof shall be binding unless made in writing and signed by the Parties by their respective officers thereunto duly authorized. 

 

	 	9.5.	Severability. In the event that any provision of this Agreement is held by a court of competent jurisdiction to be unenforceable or invalid, the validity and
enforceability of the remaining provisions shall not be affected, and the rights and obligations of the Parties shall be construed and enforced as if the Agreement did not contain the particular provisions held to be invalid or unenforceable.

  

	 	9.6.	Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of the Parties hereto and their permitted successors and assigns. Nothing
in this Agreement, express or implied, is intended to or shall confer upon any other person any right, benefit or remedy of any nature whatsoever under or by reason of this Agreement. 

 

	 	9.7.	Construction. The Parties agree that each Party has reviewed this Agreement and that any rule of construction to the effect that ambiguities are to be resolved
against the drafting Party shall not apply to the interpretation of this Agreement. 

  

	 	9.8.	Further Assurances. Each Party agrees to execute, acknowledge and deliver such further instruments and to do all such other acts as may be necessary or
appropriate in order to carry out the purposes and intent of this Agreement. 

  
 - 6 -

	 	9.9.	Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original but all of which together shall constitute
one and the same instrument. 

  

	 	9.10.	Stamp Duty. All stamp duty and penalties in respect of this Agreement or the transfer or assignment of any property agreed to be sold or in respect of any
instrument or transaction contemplated by this Agreement, shall be borne and paid by SA Pathology. 

 (Signature
Page Follow) 

  
 - 7 -

 IN WITNESS WHEREOF, the Parties have executed this Agreement effective as of the date first above written.

  

					
	SA PATHOLOGY	 		 	
			
	THE COMMON SEAL of MINISTER FOR HEALTH AND AGEING (acting as a body corporate and for and on behalf of the Crown in the right of the State of
South Australia) was hereunto affixed by authority of the Minister in presence of:	 		 	
	 		 	 /s/ John David Hill

	 		 	  
 Hon. John David Hill MP

	 		 	

  

	
	 /s/ David Colin Panter

	
	Signature of witness
	
	 David Colin Panter

	
	Name of witness in full

  

			
	BIOMARIN
		
	By:	 	 /s/ G. Eric Davis

		
	Name:	 	 G. Eric Davis

		
	Title:	 	 Managing Director

		
	Date:	 	 17 Nov, 2011

  
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 Exhibit A 
 TRANSFERRED PATENTS 
  

																	
	 SERIALNO
	 	 PATENTNO
	 	 PUBLNO
	 	 TITLE
	 	 STATUS
	 	 FILE
	 	 PUBL
	 	 ISSUE
	 	 EXPIRATION

									
	2003290642	 	2003290642	 	WO04043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2003	 	6 /3 /2004	 	10/23/2008	 	11/7 /2023
									
	200380105922.9	 	200380105922.9	 		 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2003	 	1 /25/2006	 	3 /12/2008	 	11/7 /2023
									
	PA/a/2005/004880	 	260695	 	WO/2004/043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2003	 	5 /27/2004	 	9 /22/2008	 	11/7 /2023
									
	2004-551853	 	4459059	 	WO04043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2003	 	3 /30/2006	 	2 /19/2010	 	11/7 /2023
									
	10/704,365	 	6,972,124	 		 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2003	 		 	12/6 /2005	 	11/7 /2023
									
	10/290,908	 	6,866,844	 	US 2004-0101524 A1	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2002	 	5 /27/2004	 	3 /15/2005	 	11/7 /2022
									
	092131341	 	I327919	 	WO/2004/043373	 	PRECURSOR OF N-ACETYLGAL;ACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2003	 	5 /27/2004	 	8 /1 /2010	 	11/6 /2023

																	
	 SERIALNO
	 	 PATENTNO
	 	 PUBLNO
	 	 TITLE
	 	 STATUS
	 	 FILE
	 	 PUBL
	 	 ISSUE
	 	 EXPIRATION

									
	2098/DELNP/2005	 	246952	 	WO/2004/043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	ISSUED	 	11/7 /2003	 	5 /27/2004	 	3 /23/2011	 	11/7 /2023
									
	2001255771	 	2001255771	 		 	ENZYMES USEFUL FOR TREATING AND METHODS FOR TREATING MPS-VI AND CELL LINES FOR PRODUCING SUCH ENZYMES RECOMBINANTLY	 	ISSUED	 	4 /25/2001	 		 	9 /13/2007	 	3 /20/2022
									
	10011421.4	 		 	2327414	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	PENDING	 	11/7 /2003	 	6 /1 /2011	 		 	11/7 /2023
									
	2,502,928	 		 	WO2004/043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	PENDING	 	11/7 /2003	 	5 /27/2004	 		 	11/7 /2023
									
	2009-500514	 		 	2009-529885	 	ASSAYS FOR DETECTION OF ANTIBODIES TO LYSOSOMAL ENZYMES	 	PENDING	 	3 /16/2007	 	8 /27/2009	 		 	3 /16/2027
									
	06102425.5	 		 	WO/2004/043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	PENDING	 	11/7 /2003	 	4 /13/2006	 		 	11/7 /2023
									
	PI 0316039-4	 		 	WO/2004/043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	PENDING	 	11/7 /2003	 	5 /27/2004	 		 	11/7 /2023
									
	P030104118	 		 	AR 042019 A1	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	PENDING	 	11/6 /2003	 	6 /8 /2005	 		 	11/6 /2023
									
	2,443,555	 		 	WO 0183722 A2	 	ENZYMES USEFUL FOR TREATING AND METHODS FOR TREATING MPS-VI AND CELL LINES FOR PRODUCING SUCH ENZYMES RECOMBINANTLY	 	PENDING	 	4 /25/2001	 	11/8 /2001	 		 	4 /25/2021

																	
	 SERIALNO
	 	 PATENTNO
	 	 PUBLNO
	 	 TITLE
	 	 STATUS
	 	 FILE
	 	 PUBL
	 	 ISSUE
	 	 EXPIRATION

									
	03783223.5	 		 	1565209	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	PENDING	 	11/7 /2003	 	8 /24/2005	 		 	11/7 /2023
									
	168435	 		 	WO/2004/043373	 	PRECURSOR OF N-ACETYLGALACTOSAMINE-4-SULFATASE, METHODS OF TREATMENT USING SAID ENZYME AND METHODS FOR PRODUCING AND PURIFYING SAID ENZYME	 	PENDING	 	11/7 /2003	 	5 /27/2004	 		 	11/7 /2023

 Exhibit B 
 Patent Assignment 

 ASSIGNMENT AGREEMENT 

This assignment agreement (“Assignment”) is entered into the 30th day of November, 2011 (“Effective Date”) by and
between SA Pathology, a unit of Central Adelaide Local Health Network Inc., incorporated under the Health Care Act of 2008, having its principal place of business at Frome Road, Adelaide, South Australia, Australia (“Assignor”), and BMRN
Bears Ltd., an Irish corporation resident in The Bahamas having its principle place of business at 60 Montrose Ave, Nassau, Bahamas (“Assignee”). 
 For good and valuable consideration, the receipt and sufficiency of which are agreed, Assignor hereby irrevocably sells, assigns and transfers to Assignee and its successors, assigns and legal
representatives, Assignor’s entire right, title and interest, both legal and equitable, throughout the world, in the patents and patent applications listed in the attached Schedule A, and to the inventions described therein and improvements
thereof, all related U.S., PCT and foreign patent applications including those claiming priority thereto anywhere in the world, all continuations, divisionals and continuations-in-part of any of the foregoing, patents issuing from any of the
foregoing, and reissues, reexaminations, extensions and foreign equivalents thereof and supplementary protection certificates allowed on any of the foregoing (collectively the “Patent Rights”) for Assignee’s own use and enjoyment, and
for the use and enjoyment of its successors, assigns or other legal representatives, as fully and entirely as the same would have been held and enjoyed by Assignor if this Assignment and sale had not been made; together with all income, royalties,
damages or payments due or payable as of the Effective Date or thereafter, including, without limitation, all claims for damages by reason of past, present or future infringement or other unauthorized use of the Patent Rights, with the right to sue
for, and collect the same for its own use and enjoyment, and for the use and enjoyment of its successors, assigns, or other legal representatives. 
 Upon the request of Assignee, the undersigned agrees to execute any and all documents and take actions reasonably requested to effectuate this assignment and Assignee’s rights in the Patent Rights,
including any oath or affidavit relating thereto, to cooperate to the best of the ability of the undersigned with Assignee in preparing and executing statements and giving and producing evidence in support of the Patent Rights, and to perform any
and all acts reasonably requested by Assignee to obtain, enforce and defend the Patent Rights and vest all rights therein to Assignee as fully and entirely as the same would have been held and enjoyed by the undersigned if this Assignment had not
been executed. 

 The parties execute and deliver this Assignment by their respective signatories below. 

 

					
	SA Pathology, a unit of Central Adelaide Local Health Network Inc
			
	THE COMMON SEAL of MINISTER FOR HEALTH AND AGEING (acting as a body corporate and for and on behalf of the Crown in the right of the State of South
Australia) was hereunto affixed by authority of the Minister in presence of:	 		 	
	 		 	 /s/ John David Hill

	 		 	  
 Hon. John David Hill MP

	 		 	

  

	
	 /s/ David Colin Panter

	
	Signature of witness
	
	 David Colin Panter

	
	 Name of witness in full

  

			
	BMRN Bears Ltd.
	
	 G. Eric Davis

		
	Name:	 	 G. Eric Davis

		
	Title:	 	 Managing Director

 Exhibit C 
 BPI Acknowledgement 
 BioMarin Pharmaceutical Inc., a Delaware corporation
(“BPI”) hereby acknowledges that it affiliate, BMRN Bears Ltd., an Irish corporation resident in The Bahamas (“BBL”), is purchasing certain intellectual property under lying that certain License Agreement by and
between BPI and SA Pathology, a unit of Central Adelaide Local Health Network Inc, incorporated under the Health Care Act of 2008 (“SA Pathology”) dated February 7, 2007 (“License Agreement”) pursuant to an
Asset Purchase Agreement dated November 30, 2011 (the “APA”). BPI further acknowledges that SA Pathology is entering into the APA in reliance on this acknowledgement and the commitments made by BPI herein. On such basis, BPI commits
that: 
  

	1.	BPI hereby consents to the assignment of the License Agreement as contemplated in the APA. 

 

	2.	On or before January 31, 2012, BPI shall prepare a royalty report covering the period from October 1 through the day prior to the Effective Date and shall
concurrently pay the royalty payable to SA Pathology through the day prior to the Effective Date; and 

  

	3.	As between BPI and SA Pathology, for purposes of determining the ongoing rights and obligations of BPI and SA Pathology, the License Agreement shall be deemed to have
terminated on the Effective Date of the APA. 

  

	4.	BPI hereby unconditionally guarantees the payment by BBL to SA Pathology as contemplated in Section 4 of the APA. 

Executed on behalf of BioMarin Pharmaceutical Inc. 
  

			
	 /s/ G. Eric Davis

		
	Name:	 	 G. Eric Davis

		
	Title:	 	 Sr. VP, General Counsel

 Exhibit D 
 Wire Transfer Instructions 
 [Account Information Redacted.]Lease Agreement - 770 Lindaro Street

 Exhibit 10.34 
 LEASE 
 SAN RAFAEL CORPORATE CENTER 

770 Lindaro Street 
 San Rafael, California 
 SR CORPORATE CENTER PHASE TWO, LLC,

 a Delaware limited liability company 
 as Landlord, 
 and 

BIOMARIN PHARMACEUTICAL INC, 
 a Delaware corporation 
 as Tenant. 

 TABLE OF CONTENTS 

 

					
	 	  	Page	 
		
	ARTICLE 1 PREMISES, BUILDING, PROJECT, AND COMMON AREAS	  	 	5	  
	ARTICLE 2 LEASE TERM	  	 	7	  
	ARTICLE 3 BASE RENT	  	 	11	  
	ARTICLE 4 ADDITIONAL RENT	  	 	11	  
	ARTICLE 5 USE OF PREMISES	  	 	18	  
	ARTICLE 6 SERVICES AND UTILITIES	  	 	19	  
	ARTICLE 7 REPAIRS AND MAINTENANCE	  	 	21	  
	ARTICLE 8 ADDITIONS AND ALTERATIONS	  	 	22	  
	ARTICLE 9 COVENANT AGAINST LIENS	  	 	25	  
	ARTICLE 10 INSURANCE	  	 	25	  
	ARTICLE 11 DAMAGE AND DESTRUCTION	  	 	28	  
	ARTICLE 12 NONWAIVER	  	 	30	  
	ARTICLE 13 CONDEMNATION	  	 	30	  
	ARTICLE 14 ASSIGNMENT AND SUBLETTING	  	 	31	  
	ARTICLE 15 SURRENDER OF PREMISES; OWNERSHIP AND REMOVAL OF TRADE FIXTURES	  	 	35	  
	ARTICLE 16 HOLDING OVER	  	 	36	  
	ARTICLE 17 ESTOPPEL CERTIFICATES	  	 	37	  
	ARTICLE 18 SUBORDINATION	  	 	37	  
	ARTICLE 19 DEFAULTS; REMEDIES	  	 	38	  
	ARTICLE 20 COVENANT OF QUIET ENJOYMENT	  	 	41	  
	ARTICLE 21 LETTER OF CREDIT	  	 	41	  
	ARTICLE 22 INTENTIONALLY OMITTED	  	 	45	  
	ARTICLE 23 SIGNS	  	 	45	  
	ARTICLE 24 COMPLIANCE WITH LAW	  	 	46	  
	ARTICLE 25 LATE CHARGES	  	 	46	  
	ARTICLE 26 LANDLORD’S RIGHT TO CURE DEFAULT; PAYMENTS BY TENANT	  	 	47	  
	ARTICLE 27 ENTRY BY LANDLORD	  	 	47	  
	ARTICLE 28 TENANT PARKING	  	 	48	  
	ARTICLE 29 MISCELLANEOUS PROVISIONS	  	 	49	  
	ARTICLE 30 ROOFTOP ANTENNA	  	 	59	  
	ARTICLE 31 EMERGENCY GENERATOR	  	 	63	  

 EXHIBITS 
  

			
	A	  	OUTLINE OF PREMISES
	A-1	  	SITE PLAN
	B	  	TENANT WORK LETTER
	C	  	NOTICE OF LEASE TERM DATES
	D	  	RULES AND REGULATIONS
	E	  	FORM OF TENANT’S ESTOPPEL CERTIFICATE
	F	  	FORM OF LETTER OF CREDIT
	G	  	RIGHT TO LEASE ADJACENT BUILDING AGREEMENT

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

			
	H	  	VISITOR PARKING
	I	  	DIAGRAM OF ROOFTOP AREA FOR ANTENNA
	J	  	DIAGRAMS OF EMERGENCY GENERATOR AREA AND GENERATOR FUEL PAD

  

					
		 	(-ii-)	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 INDEX 

 

					
	 	  	Page(s)	 
		
	 Additional Rent
	  	 	11	  
	 Alterations
	  	 	23	  
	 Approved Bank
	  	 	41	  
	 Bank
	  	 	41	  
	Bank Prime Loan	  	 	46	  
	 Bankruptcy Code
	  	 	42	  
	 Base Building
	  	 	23	  
	 Base Rent
	  	 	11	  
	 Brokers
	  	 	54	  
	 Building Hours
	  	 	19	  
	 Direct Expenses
	  	 	12	  
	 Estimate
	  	 	16	  
	 Estimate Statement
	  	 	16	  
	 Expense Year
	  	 	12	  
	 First Offer Notice
	  	 	6	  
	 First Offer Rent
	  	 	6, 7	  
	 Force Majeure
	  	 	52	  
	 Holidays
	  	 	19	  
	 HVAC
	  	 	19	  
	 Identification Requirements
	  	 	56	  
	 Landlord
	  	 	1	  
	 Landlord Parties
	  	 	25	  
	 Landlord Repair Notice
	  	 	28	  
	 Landlord’s Communication Equipment
	  	 	58	  
	 L-C
	  	 	41	  
	 L-C Amount
	  	 	41	  
	 L-C Expiration Date
	  	 	41	  
	 Lease
	  	 	1	  
	 Lease Commencement Date
	  	 	7	  
	 Lease Expiration Date
	  	 	7	  
	 Lease Term
	  	 	7	  
	 Lease Year
	  	 	7	  
	 Lines
	  	 	56	  
	 Mail
	  	 	52	  
	 Notices
	  	 	52	  
	 Operating Expenses
	  	 	12	  
	 Original Improvements
	  	 	26	  
	 Premises
	  	 	5	  
	 Proposition 13
	  	 	14	  
	 Provider
	  	 	57	  
	 Quoted Rent
	  	 	32	  
	 Renovations
	  	 	55	  
	 Rent
	  	 	11	  
	 Security Deposit Laws
	  	 	44	  

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

					
	 	  	Page(s)	 
		
	 Statement
	  	 	15	  
	 Subject Space
	  	 	31	  
	 Summary
	  	 	1	  
	 Tax Expenses
	  	 	14	  
	 Tenant
	  	 	1	  
	 Tenant Work Letter
	  	 	5	  
	 Tenant’s Share
	  	 	15	  
	 Termination Date
	  	 	7	  
	 Termination Notice
	  	 	8	  
	 Transfer Notice
	  	 	31	  
	 Transfer Premium
	  	 	33	  
	 Transferee
	  	 	31	  
	 Transferee’s Rent
	  	 	32	  
	 Transfers
	  	 	31	  
	 Wireless Communication Equipment
	  	 	58	  

  

					
		 	(-iv-)	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 SAN RAFAEL CORPORATE CENTER 

LEASE 
 This Lease (the “Lease”), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the “Summary”), below, is made by and between SR
CORPORATE CENTER PHASE TWO, LLC, a Delaware limited liability company (“Landlord”), and BIOMARIN PHARMACEUTICAL INC., a Delaware corporation (“Tenant”). 

SUMMARY OF BASIC LEASE INFORMATION 
  

							
	 	 	 TERMS OF LEASE
	  	 DESCRIPTION

			
	1.	 	Date:	  	December 31, 2011
			
	2.	 	Premises	  	
				
		 	2.1	 	Building:	  	That certain building located at 770 Lindaro Street, San Rafael, California, which is known and designated as “770 Lindaro” of the San Rafael Corporate Center 94901. There
are approximately 83,360 square feet in the Building.
				
		 	2.2	 	Premises:	  	Approximately 83,360 square feet for 770 Lindaro. The Premises shall mean the areas shown on pages 1 and 2 of Exhibit A to the Lease and the areas shown on
Exhibits I and J to the Lease. The Premises shall include the entire four story Building.
				
		 	2.3	 	Project:	  	The Building is part of an office project known as “San Rafael Corporate Center”, as further set forth in Section 1.1.2 of this Lease.
			
	3.	 	 Lease Term

(Article 2).
	  	
				
		 	3.1	 	Length of Term:	  	Ten (10) years plus any partial calendar month(s) at the beginning of the Term.
				
		 	3.2 	 	Lease and Rent Commencement Date:	  	  
 April 15, 2012.

  

					
		 		  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

							
		 	3.3	 	Lease Expiration Date:	  	April 14, 2022.
				
		 	3.4	 	Options to Extend	  	Two (2) options to extend, each for a five (5) year period.
			
	4.	 	 Base Rent, NNN (Article 3):
	  	
				
		 	 4.1
	 	 Amount Due:
	  	

  

													
	 Period
	  	Leased
Area sf	 	  	Monthly
Base Rent	 	  	Annualized
Base Rent (1)	 
	 Beneficial Occupancy to Lease and Rent Commencement Date
	  				  	 
 
  
	Direct
Expenses
 Only
	  
  
   
	  			
	 April 15, 2012 through July 14, 2012
	  	 	40,386	  	  	$	80,772.92	  	  	$	242,318.76	  
	 July 15, 2012 through November 14, 2012
	  	 	61,873	  	  	$	123,746.44	  	  	$	494,985.76	  
	 November 15, 2012 through April 14, 2013
	  	 	83,360	  	  	$	166,719.96	  	  	$	833,599.80	  
	 April 15, 2013 through April 14, 2014
	  	 	83,360	  	  	$	175,889.56	  	  	$	2,110,674.69	  
	 April 15, 2014 through April 14, 2015
	  	 	83,360	  	  	$	185,892.76	  	  	$	2,230,713.06	  
	 April 15, 2015 through April 14, 2016
	  	 	83,360	  	  	$	195,062.35	  	  	$	2,340,748.24	  
	 April 15, 2016 through April 14, 2017
	  	 	83,360	  	  	$	205,899.15	  	  	$	2,470,789.81	  
	 April 15, 2017 through April 14, 2018
	  	 	83,360	  	  	$	215,902.35	  	  	$	2,590,828.18	  
	 April 15, 2018 through April 14, 2019
	  	 	83,360	  	  	$	226,739.15	  	  	$	2,720,869.75	  
	 April 15, 2019 through April 14, 2020
	  	 	83,360	  	  	$	238,409.54	  	  	$	2,860,914.51	  
	 April 15, 2020 through April 14, 2021
	  	 	83,360	  	  	$	250,079.94	  	  	$	3,000,959.28	  
	 April 15, 2021 through April 14, 2022
	  	 	83,360	  	  	$	262,583.94	  	  	$	3,151,007.24	  

  

	(1)	Annualized Base Rent for the one year period from April 15, 2012 through April 14, 2013 reflects Base Rent due per period based on staged occupancy.

  

							
		 	4.2	 	Rent Payment Address:	  	 Payable to the order of SR Corporate Center Phase Two, LLC at either of the following addresses:

 
 Via U.S. Mail

 
 SR Corporate Center Phase Two LLC

P.O. Box 748132
 Los Angeles, CA
90074-8132
  
 Or

  

					
		 	-2-	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

							
		 		 		  	 Via Courier
  

Bank of America
 P.O. Box 748132

Ground Level
 1000 W. Temple Street

Los Angeles , CA 90012

			
	5.	 	[Intentionally Omitted]	  	
			
	6.	 	 Tenant’s Share

(Article 4):
	  	 100% (83,360 sf/83,360 sf) of Building Expenses.

 
 26.51% (83,360 sf/314,497 rsf) of Project Expenses.

 
 Tenant’s Share of Project Direct Expenses is subject to adjustment if
the Project rentable square footage increases in accordance with Section 29.33.3 of the Lease.

			
	7.	 	 Permitted Use
  

(Article 5):
	  	General executive and administrative office space, research and development, basic biology, and chemistry lab functions, research and development laboratory use, and development.
Additionally Tenant may construct on-site amenities within the Premises including but not limited to a fitness center and cafeteria. All use and interior improvements shall be subject to the current zoning and development agreement, or as modified
in the future, governing San Rafael Corporate Center as issued by the City of San Rafael.
			
	8.	 	 Letter of Credit

(Article 21):
	  	Four Million Seven Hundred Twenty-Six Thousand Dollars ($4,726,000), subject to reduction as provided in Article 21. This single Letter of Credit is the same Letter of Credit which
Tenant is required to deliver to Landlord under the terms of that certain Lease between Landlord and Tenant for premises at 790 Lindaro Street, San Rafael, California.

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

							
	9.	 	 Parking Pass Ratio

(Article 28):
	  	Three and Three Tenths (3.3) unreserved, non-exclusive and unlabeled parking passes for every 1,000 rentable square feet of the Premises.
			
	10.	 	 Address of Tenant

(Section 29.18):
	  	 Bio Marin Pharmaceutical Inc.

105 Digital Drive
 Novato, CA 94949

Attention: General Counsel
 (Prior to Lease
Commencement Date)
  
 With a required copy to the CFO at the
same address.

			
		 	and	  	 BioMarin Pharmaceutical Inc.

770 Lindaro Street
 San Rafael, CA
94901
 Attention: General Counsel

(After Lease Commencement Date)
  

With a required copy to the CFO at the same address.

			
	 11.
	 	 Address of Landlord

(Section 29.18):
	  	See Section 29.18 of the Lease.
			
	 12.
	 	 Broker(s)

(Section 29.24):
	  	 Cassidy Turley/BT Commercial

(Landlord’s Broker)
  

Colliers International
 (Tenant’s
Broker)]

			
	 13.
	 	 Tenant Improvement Allowance

(Section 2 of Exhibit B):
	  	$5,007,600

  

					
		 	-4-	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 ARTICLE 1  

 
 PREMISES, BUILDING, PROJECT, AND COMMON AREAS

  
 1.1 Premises, Building, Project and
Common Areas. 
  
 1.1.1 The
Premises. Landlord hereby leases to Tenant and Tenant hereby leases from Landlord the premises which are to be constructed by Tenant and are set forth in Section 2.2 of the Summary (the “Premises”). The outline of the
Premises is set forth in Exhibit A attached hereto and the Premises have approximately the number of rentable square feet as set forth in Section 2.2 of the Summary, which shall not be re-measured except as a result of a
change in the physical size of the Premises. The parties hereto agree that the lease of the Premises is upon and subject to the terms, covenants and conditions herein set forth, and Tenant covenants as a material part of the consideration for this
Lease to keep and perform each and all of such terms, covenants and conditions by it to be kept and performed and that this Lease is made upon the condition of such performance. The parties hereto hereby acknowledge that the purpose of Exhibit
A is to show the approximate location of the Premises in the “Building,” as that term is defined in Section 1.1.2, below, only, and such Exhibit is not meant to constitute an agreement, representation or warranty as to the
construction of the Premises, the precise area thereof or the specific location of the “Common Areas,” as that term is defined in Section 1.1.3, below, or the elements thereof or of the accessways to the Premises or the
“Project,” as that term is defined in Section 1.1.2, below. Except as specifically set forth in this Lease and in the Tenant Work Letter attached hereto as Exhibit B (the “Tenant Work Letter”), Landlord
shall not be obligated to provide or pay for any improvement work or services related to the improvement of the Premises. Tenant also acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty regarding the
condition of the Premises, the Building or the Project or with respect to the suitability of any of the foregoing for the conduct of Tenant’s business, except as specifically set forth in this Lease and the Tenant Work Letter. The taking of
possession of the Premises by Tenant shall conclusively establish that the Premises and the Building were at such time in good and sanitary order, condition and repair, except as specifically set forth in this Lease and the Tenant Work Letter.

  
 1.1.2 The Building and The Project.
The Premises are the entire building set forth in Section 2.1 of the Summary (the “Building”) located in San Rafael, California. The Building is part of an office project known as “The San Rafael Corporate
Center” which contains other office buildings and a parking structure (the “Adjacent Buildings”), as shown on the Site Plan attached hereto as Exhibit A-1. The term “Project,” as used in this
Lease, shall mean (i) the Building, the Adjacent Buildings, and the “Common Areas,” as that term is defined in Section 1.1.3, (ii) the land (which is improved with landscaping, surface parking facilities and
other improvements) upon which the Building, the Adjacent Buildings, and the Common Areas are located, and (iii) at Landlord’s discretion, any additional real property, areas, buildings or other improvements added thereto pursuant to the
terms of Section 29.33. 

  

					
		 		  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 1.1.3 Common Areas. Tenant shall have the non-exclusive right to use in common
with other tenants in the Project, and subject to the rules and regulations referred to in Article 5, those portions of the Project which are provided, from time to time, for use in common by Landlord, Tenant and any other tenants of the
Project, whether or not those areas are open to the general public (such areas, together with such other portions of the Project designated by Landlord, in its discretion, including certain areas designated for the exclusive use of certain tenants,
or to be shared by Landlord and certain tenants, such as balconies abutting tenants’ premises, are collectively referred to herein as the “Common Areas”). The manner in which the Common Areas are maintained and operated shall
be at the sole discretion of Landlord, provided that Landlord shall maintain and operate the same in a manner consistent with that of other first-class, mid-rise office buildings (including the office buildings constructed adjacent to the Project as
“Phase I” of The San Rafael Corporate Center, hereafter referred to as “Phase I”) in the Marin County, California area, which are comparable in terms of size, quality of construction, appearance, and services and
amenities (the “Comparable Buildings”). 
  
 1.2 Square Feet of Premises and Building. For purposes of this Lease, “square feet” of the Premises shall be deemed as set forth in Section 2.2 of the Summary and shall not be
subject to remeasurement or modification following execution of this Lease. 
  
 1.3 Exclusive Right to Lease. Tenant shall have the exclusive right to lease the to-be-built building at 791 Lincoln Avenue (“Exclusive Right”) effective as of the date of
the Lease until December 20, 2012 (the “Exclusive Right Period”), in accordance with the Right to Lease Adjacent Building Agreement, in the form attached hereto as Exhibit G. Landlord shall remove the 791 Lincoln Avenue
building from the market during this period. 
  
 1.4
Right of First Offer. In the event Tenant does not exercise its Exclusive Right prior to December 21, 2012, then throughout the Term, Tenant shall have a right of first offer (the “791 Right of First Offer”) as
set forth below, at the then existing market rent rate, as determined by Landlord in its sole and absolute discretion, to lease the 791 Lincoln Avenue building (the “First Offer Space”) should Landlord elect to build it. 

 
 1.4.1 Procedure for Offer. Landlord shall
notify Tenant (the “First Offer Notice”) when and if the First Offer Space becomes available for lease to third parties. Landlord shall give Tenant such First Offer Notice no more than eighteen (18) months and no less than
three (3) months before the anticipated delivery date of the First Offer Space. Pursuant to such First Offer Notice, Landlord shall offer to lease the First Offer Space to Tenant. The First Offer Notice shall describe when the First Offer Space
is available and shall set forth the market rate rent “First Offer Rent,” as that term is defined in Section 1.4.3 below, and the other economic terms upon which Landlord is willing to lease the First Offer Space to
Tenant. 
  
 1.4.2 Procedure for
Acceptance. If Tenant wishes to exercise Tenant’s 791 Right of First Offer, then within fifteen (15) business days following delivery of the First Offer Notice to Tenant, Tenant shall deliver notice to Landlord of Tenant’s
election to exercise its 791 Right of First Offer on the terms contained in such notice. If Tenant does not notify Landlord within the fifteen (15) business day period set forth above, then Landlord shall be free to lease the First Offer Space
to anyone to whom Landlord desires on any terms Landlord desires. Tenant must elect to exercise its 791 Right of First Offer, if at all, with respect to the entire 791 Lincoln Avenue building. 

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

 1.4.3 First Offer Space Rent. The “Rent,” as that term is defined in
Section 4.1 of this Lease, payable by Tenant for the First Offer Space (the “First Offer Rent”) shall be the market rate rent as determined by Landlord in its sole and absolute discretion. 

1.4.4 Amendment to Lease. If Tenant timely exercises Tenant’s 791 Right of First Offer, Landlord and Tenant shall as
soon as reasonably practicable execute an amendment to this Lease for such First Offer Space upon the terms and conditions as set forth in the First Offer Notice and this Section 1.4. 

ARTICLE 2 

LEASE TERM 
 2.1 In General. The terms and provisions of this Lease shall be effective as of the date of this Lease. The term of this Lease (the “Lease Term”) shall be as set forth in
Section 3.1 of the Summary, shall commence on the date set forth in Section 3.2 of the Summary (the “Lease Commencement Date”), and shall terminate on the date set forth in Section 3.3 of the Summary (the
“Lease Expiration Date”) unless this Lease is sooner terminated as hereinafter provided. For purposes of this Lease, the term “Lease Year” shall mean each consecutive twelve (12) month period during the Lease
Term; provided that the last Lease Year shall end on the Lease Expiration Date. At any time during the Lease Term, Landlord may deliver to Tenant a notice in the form as set forth in Exhibit C, attached hereto, as a confirmation only
of the information set forth therein, which Tenant shall execute and return to Landlord within ten (10) days of receipt thereof. 
 2.2 Beneficial Occupancy. Tenant shall have the right to occupy the Premises (or certain portions of the Premises) to conduct its business prior to the Lease Commencement Date, but in no
event prior to January 2, 2012, provided that (A) Tenant shall give Landlord at least ten (10) days’ prior notice of any such occupancy of the Premises (or portion thereof), (B) a temporary certificate of occupancy or its
equivalent shall have been issued by the appropriate governmental authorities for each such portion to be occupied, and (C) all of the terms and conditions of this Lease shall apply (including, without limitation Tenant’s obligation to
deliver a certificate of insurance to Landlord in accordance with the terms of Section 10.4 below), other than Tenant’s obligation to pay “Base Rent,” as that term is defined in Article 3 below. Base Rent shall
commence on the applicable Rent Commencement Date, provided that during the period April 15, 2012 through the applicable Rent Commencement Date Tenant shall pay directly or to Landlord Tenant’s Share of Building Direct Expenses.

 2.3 Early Termination Right. 
 2.3.1 In General. Provided that Tenant is not in Default under this Lease as of the date of Tenant’s delivery of the “Termination Notice,” as that term is defined below, the
Original Tenant or an Affiliate Assignee shall have the one-time right to terminate this Lease effective on the last day of the eighty-fourth (84th) full month from the Lease Commencement Date (the “Termination Date”), provided
that (i) Landlord receives written notice (the 

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

 
“Termination Notice”) from Tenant on or before the date that is twelve (12) months prior to the Termination Date stating Tenant’s election to terminate this Lease
pursuant to the terms and conditions of this Section 2.3.1, and (ii) concurrently with Landlord’s receipt of the Termination Notice, Landlord receives from Tenant the “Termination Fee”, as specified in
Section 2.3.2 below, as consideration for and as a condition precedent to such early termination. Subject to increase in accordance with Section 2.3.2 below, the “Termination Fee” shall be an amount, representing
(x) all unamortized leasing commissions and Tenant Improvements (amortized on a straight-line basis over the 120 month term of the Lease with an interest rate of eight percent (8%) per annum, and (y) and an amount equal to the Base
Rent which would have been due for the six (6) month period commencing April 15, 2019 and ending October 14, 2019. Provided that Tenant terminates this Lease pursuant to the terms of this Section 2.3.1, this Lease shall
automatically terminate and be of no further force or effect and Landlord and Tenant shall be relieved of their respective obligations under this Lease as of the Termination Date, except those obligations set forth in this Lease which relate to the
term of Tenant’s lease of the Premises and/or that specifically survive the expiration or earlier termination of this Lease, including, without limitation, the payment by Tenant of all amounts owed by Tenant under the Lease, up to and including
the Termination Date. 
 2.3.2 Termination Fee. For purposes of this Lease, the “Termination Fee” shall
mean the sum of Seven Million Four Hundred Thirty-Four Thousand Six Hundred Sixty-Five and 27/100 Dollars ($7,434,665.27). The Termination Fee is the total fee which Tenant would be required to pay to Landlord to terminate this Lease and that
certain Lease with Landlord for the premises at 790 Lindaro Street, San Rafael, California which Tenant leases from Landlord. 

2.3.3 Other Terms. The rights granted in this Section 2.3 shall be personal to the Original Tenant or an
Affiliate Assignee and may not be exercised by any other Transferee. In the event the Tenant delivers the Termination Notice to Landlord under this Lease, Tenant shall also be required to contemporaneously deliver a termination notice in accordance
with the provisions of Tenant’s lease with Landlord for the premises Tenant leases from Landlord at 790 Lindaro Street, San Rafael, California, and any additional expansion space which Tenant may have leased from Landlord in 751 and 791 Lincoln
Avenue and 750 Lindaro Street, San Rafael, California. 
 2.4 Options to Extend. 

2.4.1 Tenant shall have the right to extend the Lease Term (each an “Option to Extend”) for two (2) five-year periods
(each an “Extended Term”), provided Tenant is not in Default at the time of exercise and at the time the Extended Term commences of any of the terms, covenants and conditions of the Lease and has provided Landlord with written notice of
its intention to extend the Lease not later than twelve (12) months nor earlier than fifteen (15) months prior to the expiration of the Lease Term. The right to extend for the second Extended Term shall be of no force or effect if the
Option to Extend for the first Extended Term has not been validly exercised. The Base Rent during each Extended Term shall be the fair market rent (defined below) for the Premises. Within thirty (30) days of Tenant’s exercise of the Option
to Extend, Landlord shall notify Tenant in writing of Landlord’s determination of fair market rent and the Base Rent proposed during the applicable Extended Term. If Tenant does not agree with

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

 
Landlord’s proposal, Tenant shall so notify Landlord in writing within thirty (30) days after receipt of the proposal from Landlord. In the event that Landlord and Tenant are unable to
agree in writing upon fair market rent within fifteen (15) days after Tenant shall have notified Landlord in writing that Tenant disagrees with such determination, then within five (5) days after the expiration of such 15-day period, the
parties shall deliver to each other concurrently at a mutually agreeable place and time their respective final written estimates of fair market rent (including applicable annual increases). If each party’s estimate of fair market rent is the
same, then the fair market rent shall equal such estimate. If both parties’ final estimates of fair market rent are within a ten percent (10%) range of the higher final estimate, then fair market rent shall equal the average of the two
(2) final estimates. In every other case, fair market rent, based on the two (2) final estimates, shall be determined by arbitration as provided below in Section 2.4.2. 

Should the determination of fair market rent not be completed or agreed upon prior to the commencement of an Extended Term, Tenant shall,
commencing on the first (1st) day of the applicable Extended Term, and continuing until the fair market rent is determined under Section 2.4.2, pay as Base Rent commencing on the first (1st) day of the applicable Extended Term,
an amount equal to Landlord’s final determination of the fair market rent. If after the fair market rent is determined under Section 2.4.2, the fair market rent is less than the amount of Base Rent previously paid by Tenant for the
Premises for the applicable Extended Term, Landlord shall pay the difference to Tenant within thirty (30) days after the date of such determination, with interest thereon calculated from the date of each payment of such Base Rent by Tenant at
the rate of six percent (6%) per annum; and, if after determination of fair market rent, the fair market rent is more than the amount of Base Rent previously paid Tenant for the Premises for the applicable Extended Term, Tenant shall pay the
difference to Landlord within thirty (30) days after the date of such determination, with interest thereon calculated from the date of each payment of such Base Rent by Tenant at the rate of six percent (6%) per annum. 

2.4.2 Whenever under this Section 2.4 the determination of fair market rent is to be made by arbitration, such arbitration
shall be conducted and determined in the City of San Francisco, solely in accordance with the provisions of this Section 2.4.2. Within fifteen (15) days after the parties have exchanged their estimates of fair market rent under
Section 2.4.1, the parties shall attempt to agree upon a mutually-acceptable arbitrator meeting the criteria set forth below to determine fair market rent hereunder. If the parties are unable to agree on an arbitrator within such fifteen
(15) day period, then either party, on behalf of both, may request appointment of such arbitrator by the then head official of the San Francisco office of the American Arbitration Association, and neither party shall raise any objections as to
the appointment made by such official or as to such official’s full power and jurisdiction to entertain the application for and make the appointment. The arbitrator shall be a member of the Appraisal Institute (or its successor organization)
with a then current senior designation of MAI (or then comparable designation) currently certified under the continuing education program, shall have at least ten (10) years’ experience in appraising major Class A commercial office
buildings in the area from the Central San Rafael exit off Highway 101 and south or southern Marin County, California (“Comparable Buildings”), and shall not then be engaged or have been engaged by either Landlord or Tenant within the five
(5) year period preceding their appointment hereunder. The arbitrator shall determine which of the two estimates submitted by the parties pursuant to Section 2.4.1 is closest to the correct result in the arbitrator’s opinion.
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party. The decision of the arbitrator shall be final and binding upon the parties, absent fraud or gross error. Upon failure, refusal or inability of an arbitrator to act, his or her successor
shall be appointed in the same manner as provided for the original appointment. The party whose position is not chosen by the arbitrator shall bear the fees and expenses of the arbitrator. The attorneys’ fees and expenses of counsel and
consultants to the respective parties shall be paid by the respective party engaging such counsel or consultant. The arbitrator shall render his or her decision in writing, with counterpart copies to each party, within thirty (30) days after
his or her appointment. The arbitrator shall have no power to modify the provisions of this Lease. Landlord and Tenant agree to execute and deliver to each other a supplement to this Lease confirming the new Base Rent as determined by the method
described in this Section 2.4. 
 2.4.3 For purposes of this Lease, “fair market rent” means the rent at
which a landlord, under no compulsion to lease, would rent the Premises for the applicable Extended Term and a tenant, under no compulsion to lease, would rent the Premises for the applicable Extended Term. Fair market rent shall mean and refer to
the rent being charged by Landlord and other landlords at the time of exercise of the Option to Extend for non-renewal, non-expansion, then current, comparable non-sublease, non-encumbered, non-equity space in the Building and Comparable Buildings.
Fair market rent shall not necessarily be a monthly rent fixed during the applicable Extended Term, but may be subject to periodic adjustment. For purposes of determining fair market rent under this Lease, the following factors shall be taken into
account: (i) that the Premises are then in their “as is, where is” condition as improved with any alterations thereto made by or on behalf of Tenant in their then condition, and (ii) that Tenant could immediately occupy the
Premises in such condition for the use as permitted by the terms and conditions of this Lease. In addition, (A) the determination of fair market rent shall exclude “down time” for releasing the Premises and during the period Landlord
and Tenant are negotiating the fair market rent only the amount of an “in-house” brokerage commission on renewal shall be taken into account; (B) the determination of fair market rent shall take into account the then unamortized value
of Building standard alterations to the Premises paid for by Tenant but shall exclude any value attributable to above Building standard alterations in the Premises paid for by Tenant; and (C) the fair market rent shall include appropriate
annual increases. In the event that the fair market rent is to be determined by arbitration in accordance with this Section 2.4, notwithstanding anything to the contrary contained in the preceding sentence, the arbitrator shall take into
account all factors which an experienced arbitrator familiar with the Comparable Buildings would customarily take into account in determining the amount of fair market rent. 
 2.4.4 Tenant’s right to extend the Lease Term for an Extended Term is personal to the named Tenant and/or Affiliate Assignee under this Lease, and shall not inure to the benefit of any other assignee
or subtenant. The Option to Extend shall be void and of no further effect if at any time the named Tenant or an Affiliate Assignee under this Lease (i) assigns this Lease or (ii) subleases more than fifty percent (50%) of the rentable
square feet of the Premises for substantially the remainder of the Term. 

  

					
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 ARTICLE 3 
 BASE RENT 
 Tenant shall pay, without prior notice or demand, to
Landlord or Landlord’s agent at the address set forth in Section 4.2 of the Summary, or, at Landlord’s option, at such other place as Landlord may from time to time designate in writing, by a check for currency which, at the time of
payment, is legal tender for private or public debts in the United States of America, base rent (“Base Rent”) as set forth in Section 4 of the Summary, payable in equal monthly installments as set forth in Section 4 of the
Summary in advance on or before the first day of each and every calendar month during the Lease Term, without any setoff or deduction whatsoever. The Base Rent for the first full month of the Lease Term shall be paid at the time of Tenant’s
execution of this Lease. If any Rent payment date (including the Lease Commencement Date) falls on a day of the month other than the first day of such month or if any payment of Rent is for a period which is shorter than one month, the Rent for any
fractional month shall accrue on a daily basis for the period from the date such payment is due to the end of such calendar month or to the end of the Lease Term at a rate per day which is equal to 1/365 of the applicable annual Rent. All other
payments or adjustments required to be made under the terms of this Lease that require proration on a time basis shall be prorated on the same basis. If there is a delay in Landlord’s delivery of possession of the Premises to Tenant which
causes the Lease Commencement Date to be delayed, as provided for in Section 2.1 of the Lease, then Rent Commencement Date shall be moved to the revised Lease Commencement Date. 

ARTICLE 4 

ADDITIONAL RENT 
 4.1 General Terms. In addition to paying the Base Rent specified in Article 3 of this Lease, Tenant shall pay “Tenant’s Share” of the annual “Direct Expenses,”
as those terms are defined in Sections 4.2.6 and 4.2.2 of this Lease, respectively, commencing on April 15, 2012. Such payments by Tenant, together with any and all other amounts payable by Tenant to Landlord pursuant to the terms of this
Lease, are hereinafter collectively referred to as the “Additional Rent”, and the Base Rent and the Additional Rent are herein collectively referred to as “Rent.” All amounts due under this Article 4 as
Additional Rent shall be payable for the same periods and in the same manner as the Base Rent, provided that, to the extent practical, Tenant may elect to pay Direct Expenses for the Building (as opposed to Direct Expenses for the Project) directly
to the party to whom payment is due, rather than through reimbursement of Landlord. Without limitation on other obligations of Tenant which survive the expiration of the Lease Term, the obligations of Tenant to pay the Additional Rent provided for
in this Article 4 shall survive the expiration of the Lease Term. 
 4.2 Definitions of Key Terms Relating to
Additional Rent. As used in this Article 4, the following terms shall have the meanings hereinafter set forth: 

4.2.1 “Net Lease”. This Lease is designed as a “net lease,” and the provisions in this Lease for payment by
Tenant of Tenant’s Share of Direct Expenses are intended to pass on to Tenant and reimburse Landlord for Tenant’s Share of all Direct Expenses incurred by Landlord for the Building and the Project, except as otherwise expressly herein
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 4.2.2 “Direct Expenses” shall mean “Operating Expenses” and
“Tax Expenses.” 
 4.2.3 “Expense Year” shall mean each calendar year in which any portion of the
Lease Term falls, through and including the calendar year in which the Lease Term expires, provided that Landlord, upon notice to Tenant, may change the Expense Year from time to time to any other twelve (12) consecutive month period, and, in
the event of any such change, Tenant’s Share of Direct Expenses shall be equitably adjusted for any Expense Year involved in any such change. 
 4.2.4 “Operating Expenses” shall mean all expenses, costs and amounts of every kind and nature which are payable or accrued during any Expense Year because of or in connection with the
ownership, management, maintenance, security, repair, replacement, restoration or operation of the Project, or any portion thereof, whether paid directly by Tenant or by Landlord. Without limiting the generality of the foregoing, Operating Expenses
shall specifically include any and all of the following: (i) the cost of supplying all utilities, the cost of operating, repairing, maintaining, and renovating the utility, telephone, mechanical, sanitary, storm drainage, and elevator systems,
and the cost of maintenance and service contracts in connection therewith; (ii) the cost of licenses, certificates, permits and inspections and the cost of contesting any governmental enactments which may affect Operating Expenses, and the
costs incurred in connection with a transportation system management program or similar program; (iii) the cost of all insurance carried by Landlord pursuant to the terms of this Lease in connection with the Project; (iv) the cost of
landscaping, relamping, and all supplies, tools, equipment and materials used in the operation, repair and maintenance of the Project, or any portion thereof; (v) costs incurred in connection with the parking areas servicing the Project;
(vi) fees and other costs, including management and/or incentive fees, consulting fees, legal fees and accounting fees, of all contractors and consultants in connection with the management, operation, maintenance and repair of the Project;
(vii) payments under any equipment rental agreements and the fair rental value of any management office space; (viii) wages, salaries and other compensation and benefits, including taxes levied thereon, of all persons engaged in the
operation, maintenance and security of the Project; (ix) payments, fees or charges under any easement, license, operating agreement, declaration, restrictive covenant, or any instrument pertaining to the sharing of costs by the Project, or any
portion thereof; (x) operation, repair, maintenance and replacement of all systems and equipment and components thereof of the Building; (xi) the cost of janitorial, alarm, security and other services, replacement of wall and floor
coverings, ceiling tiles and fixtures in common areas, maintenance and replacement of curbs and walkways, repair to roofs and re-roofing; (xii) amortization (including interest on the unamortized cost) of the cost of acquiring or the rental
expense of personal property used in the maintenance, operation and repair of the Project, or any portion thereof; (xiii) the cost of capital improvements or other costs incurred in connection with the Project (A) which are intended to
effect economies in the operation or maintenance of the Project, or any portion thereof, (B) that are required to comply with present or anticipated conservation programs, (C) which are replacements or modifications of nonstructural items
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governmental law or regulation; provided, however, that any capital expenditure shall be amortized with interest over its useful life determined in accordance with generally accepted accounting
principles, or (E) that relate to the safety or security of the Project, its occupant and visitors, and are deemed advisable in the reasonable judgment of Landlord; (xiv) costs, fees, charges or assessments imposed by, or resulting from
any mandate imposed on Landlord by, any federal, state or local government for fire and police protection, trash removal, community services, or other services which do not constitute “Tax Expenses” as that term is defined in
Section 4.2.5, below; and (xv) payments under any easement, license, operating agreement, declaration, restrictive covenant, or instrument pertaining to the sharing of costs by the Building. 

Operating Expenses shall not include: (a) the cost capital items (except as set forth above); (b) depreciation; ( c) interest
(except as provided above for the amortization of capital improvements); (d) rental on any ground or underlying lease or points, fees and principal payments of mortgage and other non-operating debts of Landlord or other costs incurred in
connection therewith, including penalties and charges incurred as a result of Landlord’s late payment; (e) costs in connection with leasing space in the Building, including tenant improvements, brokerage commissions, legal fees and
advertising or promotions; (f) market concessions granted to specific tenants; (g) costs incurred in connection with the sale, financing or refinancing of the Building; (h) Taxes (defined in Section 4.2.5); any fines, interest
and penalties incurred due to the late payment thereof; (i) organizational expenses associated with the creation and operation of the entity which constitutes Landlord; (j) any penalties or damages that Landlord pays to Tenant under this
Lease or to other tenants in the Building under their respective leases; (k) costs incurred by Landlord for structural repairs, or building construction defects, or costs which are covered by and reimbursable under any contractor, manufacturer
or supplier warranty; (l) costs arising from the adjudicated negligence of Landlord or its agents; (m) costs or expenses incurred due to adjudicated violations by Landlord of any laws, rules, regulations, or ordinances applicable to the
Property; (n) reserves for future expenditures that would be incurred subsequent to the current accounting year; (o) the initial cost of the installation or construction of any parking areas; (p) costs of art and sculptures except as
typical of comparable buildings in Marin County; (q) legal fees, advertising, and marketing expenses and other such costs incurred in connection with the development, marketing, or leasing of the Project (r) costs or expenses for
correcting defects in the design or construction of the Project; (s) costs or expenses incurred that are subject to reimbursement by tenants (including, without limitation, Tenant) or third parties (including, without limitation, insurers);
(t) expenses in connection with services or other benefits of a type which Tenant is not entitled to receive under the Lease; (u) costs incurred in negotiating, amending, administering or terminating leases, any brokerage commissions, or
construction or planning expenses; (v) overhead and profit paid to subsidiaries or affiliates of Landlord for services on or to the Building, the Project and/or Premises, to the extent only that the costs of such services exceed competitive
costs for such services were they not so rendered by a subsidiary or affiliate; provided, however, that the property management fee charged by Landlord or an affiliate of Landlord shall not be in excess of the rates then customarily charged for
building management for buildings of like class and character; in circumstances where tenants perform operation, management, repair and maintenance in the same manner as Tenant is required to perform under this Lease; (w) costs incurred to
test, survey, cleanup, contain abate, remove, or otherwise remedy Hazardous or Toxic Material (as defined in Section 5.3) at the Property, other materials and in quantities commonly found in office environments; or (x) costs or expenses of
leasing any item if the purchase price of such item is not properly chargeable as an Operating Expense. 

  

					
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 4.2.5 Taxes. 

4.2.5.1 “Tax Expenses” shall mean all federal, state, county, or local governmental or municipal taxes, fees, charges
or other impositions of every kind and nature, whether general, special, ordinary or extraordinary, (including, without limitation, real estate taxes, general and special assessments, transit taxes, leasehold taxes or taxes based upon the receipt of
rent, including gross receipts or sales taxes applicable to the receipt of rent, unless required to be paid by Tenant, personal property taxes imposed upon the fixtures, machinery, equipment, apparatus, systems and equipment, appurtenances,
furniture and other personal property used in connection with the Project, or any portion thereof), which shall be paid or accrued during any Expense Year (without regard to any different fiscal year used by such governmental or municipal authority)
because of or in connection with the ownership, leasing and operation of the Project, or any portion thereof. 
 4.2.5.2 Tax
Expenses shall include, without limitation: (i) Any tax on the rent, right to rent or other income from the Project, or any portion thereof, or as against the business of leasing the Project, or any portion thereof; (ii) Any assessment,
tax, fee, levy or charge in addition to, or in substitution, partially or totally, of any assessment, tax, fee, levy or charge previously included within the definition of real property tax, it being acknowledged by Tenant and Landlord that
Proposition 13 was adopted by the voters of the State of California in the June 1978 election (“Proposition 13”) and that assessments, taxes, fees, levies and charges may be imposed by governmental agencies for such services as fire
protection, street, sidewalk and road maintenance, refuse removal and for other governmental services formerly provided without charge to property owners or occupants, and, in further recognition of the decrease in the level and quality of
governmental services and amenities as a result of Proposition 13, Tax Expenses shall also include any governmental or private assessments or the Project’s contribution towards a governmental or private cost-sharing agreement for the purpose of
augmenting or improving the quality of services and amenities normally provided by governmental agencies; (iii) Any assessment, tax, fee, levy, or charge allocable to or measured by the area of the Premises or the Rent payable hereunder,
including, without limitation, any business or gross income tax or excise tax with respect to the receipt of such rent, or upon or with respect to the possession, leasing, operating, management, maintenance, alteration, repair, use or occupancy by
Tenant of the Premises, or any portion thereof; and (iv) Any assessment, tax, fee, levy or charge, upon this transaction or any document to which Tenant is a party, creating or transferring an interest or an estate in the Premises. 

4.2.5.3 Any costs and expenses (including, without limitation, reasonable attorneys’ fees) incurred in attempting to protest,
reduce or minimize Tax Expenses shall be included in Tax Expenses in the Expense Year such expenses are paid. Refunds of Tax Expenses shall be credited against Tax Expenses and refunded to Tenant regardless of when received, based on the Expense
Year to which the refund is applicable, provided that in no event shall the amount to be refunded to Tenant for any such Expense Year exceed the total amount paid by Tenant as Additional Rent under this Article 4 for such Expense Year. If Tax
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thereof for any reason, including, without limitation, error or reassessment by applicable governmental or municipal authorities, Tenant shall pay Landlord within thirty (30) days of demand
Tenant’s Share of any such increased Tax Expenses included by Landlord as Tax Expenses pursuant to the terms of this Lease. Notwithstanding anything to the contrary contained in this Section 4.2.5 (except as set forth in
Section 4.2.5.1, above), there shall be excluded from Tax Expenses (i) all excess profits taxes, franchise taxes, gift taxes, capital stock taxes, inheritance and succession taxes, estate taxes, federal and state income taxes, and other
taxes to the extent applicable to Landlord’s general or net income (as opposed to rents, receipts or income attributable to operations at the Project), (ii) any items included as Operating Expenses, and (iii) any items paid by Tenant
under Section 4.5 of this Lease. 
 4.2.5.4. Notwithstanding anything to the contrary set forth in this Lease, the amount
of Tax Expenses for any Expense Year shall be calculated taking into account any decreases in real estate taxes obtained in connection with Proposition 8, and, therefore, the Tax Expenses in an Expense Year may be greater than those actually
incurred by Landlord, but shall, nonetheless, be the Tax Expenses due under this Lease; provided that (i) any costs and expenses incurred by Landlord in securing any Proposition 8 reduction shall be included in Direct Expenses for purposes of
this Lease, and (ii) tax refunds under Proposition 8 shall be deducted from Tax Expenses. Landlord and Tenant acknowledge that this Section 4.2.5.4 is not intended to in any way affect (A) the inclusion in Tax Expenses of the
statutory two percent (2.0%) annual increase in Tax Expenses (as such statutory increase may be modified by subsequent legislation), or (B) the inclusion or exclusion of Tax Expenses pursuant to the terms of Proposition 13, which shall be
governed pursuant to the terms of Sections 4.2.5.1 through 4.2.5.3, above. 
 4.2.6 “Tenant’s Share” shall
mean the percentages set forth in Section 6 of the Summary. 
 4.3 Allocation of Direct Expenses. 

4.3.1 Method of Allocation. The parties acknowledge that the Building is a part of a multi-building project. Building
Direct Expenses shall, to the extent practical, be paid directly by Tenant to the parties to whom payment is due, and Project Direct Expenses shall be determined annually, paid by Landlord and allocated to Tenant in proportion with Tenant’s
Share and to the tenants of the other buildings in the Project in accordance with their shares, calculated using the same formula used to calculate Tenant’s Share with respect to Project Direct Expenses. Building Direct Expenses which cannot be
paid directly by Tenant shall be paid by Landlord and allocated to Tenant in proportion to Tenant’s Share of Building Direct Expenses. 
 4.4 Calculation and Payment of Additional Rent. For each Expense Year ending or commencing within the Lease Term, Tenant shall pay to Landlord as Additional Rent Tenant’s Share of
Direct Expenses for such Expense Year in the manner set forth in Section 4.4.1 below. 
 4.4.1
Statement of Actual Direct Expenses and Payment by Tenant. Landlord shall give to Tenant following the end of each Expense Year (and no later than the following May 1st), a statement (the “Statement”) which shall state the Project Direct Expenses and Building Direct
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by Tenant) for such preceding Expense Year and shall also state the amount of payments made by Tenant on account of the Estimate given to Tenant under Section 4.4.2. Upon receipt of the
Statement for each Expense Year commencing or ending during the Lease Term, if Tenant has paid less in estimated payments than the amount shown due on the Statement, Tenant shall pay, with its next installment of Base Rent due, the full amount of
the difference for such Expense Year. If on the basis of the Statement Tenant owes an amount that is less than the estimated payments for such calendar year previously made by Tenant, Landlord shall credit such excess to Tenant against the rent owed
by Tenant as it becomes due, except that if such excess exists at the termination of this Lease, Landlord shall refund any such excess payments to Tenant if Tenant is not in default. The failure of Landlord to timely furnish the Statement for any
Expense Year shall not prejudice Landlord or Tenant from enforcing its rights under this Article 4, provided that failure to furnish the Statement for more than twenty-four (24) months following the date it should have been delivered shall
be deemed Landlord’s waiver if its right to demand any amount due on account of Direct Expenses for the applicable Expense Year. Even though the Lease Term has expired and Tenant has vacated the Premises, when the final determination is made of
Tenant’s Share of Direct Expenses for the Expense Year in which this Lease terminates, if an amount is due from Tenant as shown on the Statement, Tenant shall immediately pay to Landlord such amount, and if Tenant has paid more in payments on
account of the Estimate, Landlord shall promptly refund such excess to Tenant. The provisions of this Section 4.4.1 shall survive the expiration or earlier termination of the Lease Term. 

4.4.2 Statement of Estimated Direct Expenses. In addition, Landlord shall give Tenant on or before the Rent Commencement
Date, and on or before the first day of January of each year thereafter during the Term, or as soon thereafter as practicable, a yearly expense estimate statement (the “Estimate Statement”) which shall set forth Landlord’s
reasonable estimate (the “Estimate”) of what the total amount of Direct Expenses for the then-current Expense Year shall be. The failure of Landlord to timely furnish the Estimate Statement for any Expense Year shall not preclude
Landlord from enforcing its rights to collect any Estimate under this Article 4, nor shall Landlord be prohibited from revising any Estimate Statement or Estimate theretofore delivered to the extent necessary. Thereafter, Tenant shall pay, with
its next installment of Base Rent due, a fraction of the Estimate for the then-current Expense Year (reduced by any amounts paid pursuant to the next to last sentence of this Section 4.4.2). Such fraction shall have as its numerator the number
of months which have elapsed in such current Expense Year, including the month of such payment, and twelve (12) as its denominator. Until a new Estimate Statement is furnished (which Landlord shall have the right to deliver to Tenant at any
time), Tenant shall pay monthly, with the monthly Base Rent installments, an amount equal to one-twelfth (1/12) of the total Estimate set forth in the previous Estimate Statement delivered by Landlord to Tenant. 

4.5 Taxes and Other Charges for Which Tenant Is Directly Responsible. 

4.5.1 Tenant shall be liable for and shall pay ten (10) days before delinquency, taxes levied against Tenant’s equipment,
furniture, fixtures and any other personal property located in or about the Premises. If any such taxes on Tenant’s equipment, furniture, fixtures and any other personal property are levied against Landlord or Landlord’s property or if the
assessed value of Landlord’s property is increased by the inclusion therein of a value placed upon such equipment, furniture, fixtures or any other personal property and if Landlord pays the

  

					
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taxes based upon such increased assessment, which Landlord shall have the right to do regardless of the validity thereof but only under proper protest if requested by Tenant, Tenant shall upon
demand repay to Landlord the taxes so levied against Landlord or the proportion of such taxes resulting from such increase in the assessment, as the case may be. 
 4.5.2 All Tax Expenses assessed on tenant improvements in the Premises for real property tax purposes, whether installed and/or paid for by Landlord or Tenant and whether or not affixed to the real
property so as to become a part thereof, shall be deemed to be taxes levied against personal property of Tenant and shall be governed by the provisions of Section 4.5.1, above. 

4.5.3 Notwithstanding any contrary provision herein, Tenant shall pay prior to delinquency any (i) rent tax or sales tax, service
tax, transfer tax or value added tax, or any other applicable tax on the rent or services herein or otherwise respecting this Lease, (ii) taxes assessed upon or with respect to the possession, leasing, operation, management, maintenance,
alteration, repair, use or occupancy by Tenant of the Premises or any portion of the Project, including the Project parking facility; or (iii) taxes assessed upon this transaction or any document to which Tenant is a party creating or
transferring an interest or an estate in the Premises. 
 4.6 Landlord’s Books and Records. Within one (1) year
after receipt of a Statement by Tenant, but not more frequently than one (1) time per year, if Tenant disputes the amount of Additional Rent set forth in the Statement, either an employee of Tenant, or an independent certified public accountant
(which accountant is a member of a nationally recognized accounting firm and is not working on a contingency fee basis), designated and paid for by Tenant, may, after ten (10) days’ notice to Landlord and at reasonable times, inspect
Landlord’s records with respect to the Statement at Landlord’s local offices, provided that Tenant is not then in Default under this Lease and Tenant has paid all amounts required to be paid under the applicable Estimate Statement and
Statement, as the case may be. In connection with such inspection, Tenant and Tenant’s agents must agree in advance to follow Landlord’s reasonable rules and procedures regarding inspections of Landlord’s records, and shall execute a
commercially reasonable confidentiality agreement regarding such inspection. Tenant’s failure to dispute the amount of Additional Rent set forth in any Statement within one (1) year of Tenant’s receipt of such Statement shall be
deemed to be Tenant’s approval of such Statement and Tenant, thereafter, waives the right or ability to dispute the amounts set forth in such Statement. If after such inspection, Tenant still disputes such Additional Rent, a determination as to
the proper amount shall be made, at Tenant’s expense, by an independent certified public accountant (the “Accountant”) selected by Landlord and subject to Tenant’s reasonable approval; provided that if such determination by the
Accountant proves that Direct Expenses were overstated by more than five percent (5%), then the cost of the Accountant and the cost of such determination shall be paid for by Landlord. Tenant hereby acknowledges that Tenant’s sole right to
inspect Landlord’s books and records and to contest the amount of Direct Expenses payable by Tenant shall be as set forth in this Section 4.6, and Tenant hereby waives any and all other rights pursuant to applicable law to inspect such
books and records and/or to contest the amount of Direct Expenses payable by Tenant. 

  

					
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 ARTICLE 5 
 USE OF PREMISES 
 5.1 Permitted Use. Tenant shall use
the Premises solely for the Permitted Use set forth in Section 7 of the Summary and Tenant shall not use or permit the Premises or the Project to be used for any other purpose or purposes whatsoever without the prior written consent of
Landlord, which may be withheld in Landlord’s sole discretion. Landlord hereby covenants to take, at its sole cost and expense, all actions necessary to ensure that the Permitted Use under this Lease is permitted under the applicable laws of
the City of San Rafael, including, without limitation, an amendment of any development agreement or use permit currently in place for the Project (collectively, the “San Rafael Zoning”). 

5.2 Prohibited Uses. The uses prohibited under this Lease shall include, without limitation, (a) use of the Premises
or a portion thereof for (i) offices of any agency or bureau of the United States or any state or political subdivision thereof; (ii) offices or agencies of any foreign governmental or political subdivision thereof; (iii) schools or
other training facilities which are not ancillary to corporate, executive or professional office use; (iv) retail uses; or (v) communications firms such as radio and/or television stations, and (b) use of the Premises for retail
banking operations, which shall include depository operations, issuance and sales of certificates of deposit, or establishing and maintaining money market and savings accounts and other deposit-based accounts and investments. Tenant further
covenants and agrees that Tenant shall not use, or suffer or permit any person or persons to use, the Premises or any part thereof for any use or purpose contrary to the provisions of the Rules and Regulations set forth in Exhibit D,
attached hereto, or in violation of the laws of the United States of America, the State of California, or the ordinances, regulations or requirements of the local municipal or county governing body or other lawful authorities having jurisdiction
over the Project) including, without limitation, any such laws, ordinances, regulations or requirements relating to hazardous materials or substances, as those terms are defined by applicable laws now or hereafter in effect. Tenant shall not do or
permit anything to be done in or about the Premises which will in any way damage the reputation of the Project or obstruct or interfere with the rights of other tenants or occupants of the Building, or injure or annoy them or use or allow the
Premises to be used for any improper, unlawful or objectionable purpose, nor shall Tenant cause, maintain or permit any nuisance in, on or about the Premises. Tenant shall comply with all recorded covenants, conditions, and restrictions now or
hereafter affecting the Project. 
 5.3 Hazardous or Toxic Material. Except as otherwise provided in this Lease,
Tenant shall not cause or knowingly permit the receipt, storage, use, location or handling on the Property (including the Building and Premises) of any product, material or merchandise which is explosive, highly inflammable, or a “hazardous or
toxic material,” as that term is hereafter defined. “Hazardous or toxic material” shall include all materials or substances which have been determined to be hazardous to health or the environment, including, without limitation
hazardous waste (as defined in the Resource Conservation and Recovery Act); hazardous substances (as defined in the Comprehensive Emergency Response, Compensation and Liability Act, as amended by the Superfund Amendments and Reauthorization Act);
gasoline or any other petroleum product or by-product or other hydrocarbon derivative; toxic substances, (as defined by the Toxic Substances Control Act); insecticides, fungicides or rodenticide, (as defined in the

  

					
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Federal Insecticide, Fungicide, and Rodenticide Act); asbestos and radon and substances determined to be hazardous under the Occupational Safety and Health Act or regulations promulgated
thereunder. Notwithstanding the foregoing or anything else in this Lease to the contrary, Tenant shall have the right to use in the Premises and at the Property the following hazardous or toxic materials (“Permitted Hazardous Materials”)
so long as such materials are used in compliance with all applicable laws, ordinances and regulations and in reasonable amounts required for Tenant’s normal and customary business operations as part of the Permitted Use: (i) hazardous or
toxic materials that are customarily present in a general office use (e.g., copying machine chemicals, printer toner, cleaning supplies, standard batteries and other similar items); (ii) nitrogen, compressed air and other hazardous materials
customarily used in a laboratory of the type Tenant intends to operate. Notwithstanding anything in this Lease to the contrary, Tenant shall not be liable for any cost or expense related to testing, removal, transportation, storage, cleaning,
abatement or remediation of hazardous or toxic materials (including, without limitation, hazardous or toxic materials in the ground water or soil): (X) located outside the Premises, except to the extent caused by any act or negligent omission
of Tenant or its agents, employees and contractors, and (Y) existing in the Premises prior to the date Landlord tenders possession of the Premises to Tenant, and (Z) that migrates on or under the Premises from and after the date Landlord
tenders possession of the Premises to Tenant except to the extent such migration is due to any act of Tenant or Tenant’s agents, employees or contractors. To Landlord’s actual knowledge, there are no hazardous materials at the Building in
violation of environmental laws. For purposes of this Section, “Landlord’s actual knowledge” shall be deemed to mean and limited to the current actual knowledge of Willis K. Polite Jr. and the property manager for the Building at the
time of execution of this Lease, whom Landlord represents and warrants to Tenant are the persons most likely to have the knowledge described, and not any implied, imputed, or constructive knowledge of said individuals or of Landlord or any parties
related to or comprising Landlord and without any independent investigation or inquiry having been made or any implied duty to investigate or make any inquiries; it being understood and agreed that such individuals shall have no personal liability
in any manner whatsoever hereunder or otherwise related to the transactions contemplated hereby. 
 ARTICLE 6 

SERVICES AND UTILITIES 
 6.1 Standard Tenant Services. Except to the extent that Tenant elects to arrange for the following directly from the utilities or providers, Landlord shall provide the following services on
all days (unless otherwise stated below) during the Lease Term. 
 6.1.1 Tenant shall be responsible, subject to limitations
imposed by all governmental rules, regulations and guidelines applicable thereto, to obtain heating and air conditioning (“HVAC”) for its own use in the Premises. While the Project contains multi-tenant buildings in which Landlord
is responsible for providing HVAC when necessary for normal comfort for normal office use from 8:00 A.M. to 6:00 P.M. Monday through Friday (the “Building Hours”), except for the date of observation of New Year’s Day,
President’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and, at Landlord’s discretion, other nationally recognized holidays (collectively, the “Holidays”), Tenant, in its sole
discretion, shall control the hours of operation of the HVAC within the Premises. 

  

					
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 6.1.2 Landlord shall provide adequate electrical wiring and facilities for connection to
Tenant’s lighting fixtures and incidental use equipment, provided that (i) the connected electrical load of the incidental use equipment does not exceed an average of watts per usable square foot of the Premises during the Building Hours
on a monthly basis, and the electricity so furnished for incidental use equipment will be at a nominal one hundred twenty (120) volts and no electrical circuit for the supply of such incidental use equipment will require a current capacity
exceeding twenty (20) amperes, and (ii) the connected electrical load of Tenant’s lighting fixtures does not exceed an average of watts per usable square foot of the Premises during the Building Hours on a monthly basis, and the
electricity so furnished for Tenant’s lighting will be at a nominal one hundred twenty (120) volts, which electrical usage shall be subject to applicable laws and regulations, including Title 24. Tenant will design Tenant’s electrical
system serving any equipment producing nonlinear electrical loads to accommodate such nonlinear electrical loads, including, but not limited to, oversizing neutral conductors, derating transformers and/or providing power-line filters. Engineering
plans shall include a calculation of Tenant’s fully connected electrical design load with and without demand factors and shall indicate the number of watts of unmetered and submetered loads. Tenant shall bear the cost of replacement of lamps,
starters and ballasts for non-Building standard lighting fixtures within the Premises. 
 6.1.3 Landlord shall provide city
water from the regular Building outlets for drinking, lavatory and toilet purposes in the Building Common Areas and in the Premises, provided that it shall be Tenant’s responsibility at its expense and as part of the Tenant Improvements
described in Exhibit B attached to distribute the city water within the Premises from the point to which the city water service line is stubbed on the floor of the Building in which the Premises are located. 

6.1.4 Landlord shall provide window washing services in a manner consistent with other comparable buildings in the vicinity of the
Building. 
 6.1.5 Tenant shall manage its own exclusive, non-attended automatic passenger elevator service. 

Tenant shall cooperate fully with Landlord at all times and abide by all regulations and requirements not inconsistent with the terms of
this Lease that Landlord may reasonably prescribe for the proper functioning and protection of the HVAC, electrical, mechanical (control systems included), fire and life safety systems, fire sprinkler systems, roof and plumbing systems. 

6.2 Intentionally Omitted. 
 6.3 Interruption of Use. Except to the extent caused by the gross negligence or willful misconduct of Landlord or its employees, agents or contractors, Tenant agrees that Landlord shall not
be liable for damages, by abatement of Rent or otherwise, for failure to furnish or delay in furnishing any service (including telephone and telecommunication services), 

  

					
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or for any diminution in the quality or quantity thereof, when such failure or delay or diminution is occasioned, in whole or in part, by breakage, repairs, replacements, or improvements, by any
strike, lockout or other labor trouble, by inability to secure electricity, gas, water, or other fuel at the Building or Project after reasonable effort to do so, by any riot or other dangerous condition, emergency, accident or casualty whatsoever,
by act or default of Tenant or other parties, or by any other cause; and such failures or delays or diminution shall never be deemed to constitute an eviction or disturbance of Tenant’s use and possession of the Premises or relieve Tenant from
paying Rent or performing any of its obligations under this Lease. Notwithstanding anything to the contrary in this Lease, if Tenant’s use or occupancy of the Premises is substantially impaired thereby for a period of more than five
(5) consecutive days, Base Rent and Additional Rent payable by Tenant shall abate until such substantial impairment ceases. Furthermore, Landlord shall not be liable under any circumstances (other than the gross negligence or willful misconduct
of Landlord or its employees, agents or contractors) for a loss of, or injury to, property or for injury to, or interference with, Tenant’s business, including, without limitation, loss of profits, however occurring, through or in connection
with or incidental to a failure to furnish any of the services or utilities as set forth in this Article 6. Landlord may comply with voluntary controls or guidelines promulgated by any governmental entity relating to the use or conservation of
energy, water, gas, light or electricity or the reduction of automobile or other emissions without creating any liability of Landlord to Tenant under this Lease, provided that the Premises are not thereby rendered untenantable. 

ARTICLE 7 

REPAIRS AND MAINTENANCE 
 7.1 Tenant shall maintain in good condition and operating order and keep in good repair and condition the stairs, stairwells, elevator cabs, restrooms, Building mechanical, electrical and telephone
closets, and all common and public areas (collectively, “Tenant’s Building Structure”), and the base building mechanical, electrical, life safety, plumbing, vertical transportation system, sprinkler systems and the heating,
ventilating and air conditioning (“HVAC”) systems (collectively, the “Building Systems”), in a first-class manner at least as good as that maintained by Landlord in other buildings in the Project. Subject to
Landlord’s reasonable approval, at least once each Lease Year, Tenant, at Tenant’s sole cost and expense, shall procure and maintain service contracts with specific terms which are comparable to those maintained by Landlord for other
buildings in the Project, with copies of the contracts and the service contract providers’ insurance certificates naming Landlord and Landlord’s managing agent as additional insureds, to Landlord within thirty (30) days of execution,
with contractors reasonably approved by Landlord, which specialize in and are experienced in the maintenance and repair of the Tenant’s Building Structure, HVAC and Building Systems. Failure to provide the service contracts and/or evidence of
insurance as required herein prior to performance of any services by such service contractors shall constitute an Event of Default under this Lease. In lieu of complying with Tenant’s obligations under this Section 7.1, Tenant may arrange
with Landlord to perform Tenant’s obligations under this Section 7.1 and to reimburse Landlord within twenty (20) days of being billed therefor for all costs and expenses incurred by Landlord in connection with providing such
contracts and services. If Tenant fails to perform its obligations under this Section 7.1, after five (5) days’ notice from Landlord to Tenant of such failure and Tenant’s failure to cure such failure within such five
(5) day period, Landlord may on notice to Tenant take over rendering such services and bill Tenant for the cost thereof. 

  

					
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 7.2 Landlord shall maintain in good condition and operating order and keep in good repair
and condition the Common Areas, and the structural portions of the Building, including the foundation, floor/ceiling slabs, roof, curtain wall, exterior glass and mullions, columns, and beams (collectively, “Landlord’s Building
Structure”), and shall perform any reasonably required capital repairs and/or improvement to the Building, subject to being reimbursed for Tenant’s Share of the costs and expenses thereof, in accordance with the provisions of Sections
4.2.4 and 4.3. 
 7.3 Subject to Landlord’s obligations under Section 7.2, Tenant shall, at Tenant’s own expense,
pursuant to the terms of this Lease, including without limitation Article 8 hereof, keep the Premises, including all improvements, fixtures and furnishings therein, in good order, repair and condition at all times during the Lease Term and Tenant
shall, at Tenant’s own expense, but under the supervision and subject to the prior approval of Landlord, and within any reasonable period of time specified by Landlord, pursuant to the terms of this Lease, including without limitation Article 8
hereof, promptly and adequately repair all damage to the Premises and replace or repair all damaged, broken, or worn fixtures and appurtenances, except for damage caused by ordinary wear and tear or beyond the reasonable control of Tenant; provided
however, that, at the Landlord’s reasonable discretion if Tenant fails to make such repairs, Landlord may, but need not, make such repairs and replacements, and Tenant shall pay Landlord the cost thereof, including a percentage of the cost
thereof (to be uniformly established for the Building and/or the Project) sufficient to reimburse Landlord for all overhead, general conditions, fees and other costs or expenses arising from Landlord’s involvement with such repairs and
replacements forthwith upon being billed for same. Landlord may, but shall not be required to, enter the Premises at all reasonable times upon reasonable prior notice to make such repairs, alterations, improvements or additions to the Premises or to
the Project or to any equipment located in the Project as required or permitted by this Lease or as Landlord may be required to do by governmental or quasi-governmental authority or court order or decree. Tenant hereby waives any and all rights
under and benefits of subsection 1 of Section 1932 and Sections 1941 and 1942 of the California Civil Code or under any similar law, statute, or ordinance now or hereafter in effect. Tenant shall at its own expense provide daily janitorial
service in the Premises under similar or higher specifications than those maintained by Landlord in Adjacent Buildings and pay for trash and garbage removal from the Premises to the designated Building trash and garbage collection area. Tenant shall
be required to keep the Premises in good and clean condition and dispose of any hazardous or toxic materials, including biohazard waste in accordance with applicable laws and not in the Building trash receptacles. 

ARTICLE 8 

ADDITIONS AND ALTERATIONS 
 8.1 Landlord’s Consent to Alterations. Following completion of the Tenant Improvements in accordance with the terms of the Tenant Work Letter attached to this Lease as Exhibit B,
Tenant may not make any improvements, alterations, additions or changes to the Premises or any mechanical, plumbing or HVAC facilities or systems pertaining to the Premises 

  

					
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(collectively, the “Alterations”) without first procuring the prior written consent of Landlord to such Alterations, which consent shall be requested by Tenant not less than
thirty (30) days prior to the commencement thereof, and which consent shall not be unreasonably withheld by Landlord, provided it shall be deemed reasonable for Landlord to withhold its consent to any Alteration which adversely affects the
structural portions or the systems or equipment of the Building or is visible from the exterior of the Building. The construction of the initial improvements to the Premises shall be governed by the terms of the Tenant Work Letter and not the terms
of this Article 8. 
 8.2 Manner of Construction. Landlord may impose, as a condition of its consent to any
and all Alterations or repairs of the Premises or about the Premises, such requirements as Landlord in its reasonable discretion may deem desirable, including, but not limited to, the requirement that Tenant utilize for such purposes only
contractors, subcontractors, materials, mechanics and materialmen selected by Tenant from a list provided and approved by Landlord, the requirement that upon Landlord’s request (given concurrently with Landlord’s consent to installation of
the subject Alterations), Tenant shall, at Tenant’s expense, remove such Alterations upon the expiration or any early termination of the Lease Term, and the requirement that all Alterations conform in terms of quality to the building’s
standards established by Landlord. If such Alterations will involve the use of or disturb hazardous materials or substances existing in the Premises, Tenant shall comply with Landlord’s rules and regulations concerning such hazardous materials
or substances. Tenant shall construct such Alterations and perform such repairs in a good and workmanlike manner, in conformance with any and all applicable federal, state, county or municipal laws, rules and regulations and pursuant to a valid
building permit, issued by the City of San Rafael, all in conformance with Landlord’s reasonable construction rules and regulations. In the event Tenant performs any Alterations in the Premises which require or give rise to governmentally
required changes to the “Base Building,” as that term is defined below, then Landlord shall, at Tenant’s expense, make such changes to the Base Building. The “Base Building” shall include the structural portions of
the Building, and the public restrooms and the systems and equipment located in the internal core of the Building on the floor or floors on which the Premises are located. In performing the work of any such Alterations, Tenant shall have the work
performed in such manner so as not to obstruct access to the Project or any portion thereof, by any other tenant of the Project, and so as not to obstruct the business of Landlord or other tenants in the Project. Tenant shall not use (and upon
notice from Landlord shall cease using) contractors, services, workmen, labor, materials or equipment that, in Landlord’s reasonable judgment, would disturb labor harmony with the workforce or trades engaged in performing other work, labor or
services in or about the Building or the Common Areas. In addition to Tenant’s obligations under Article 9 of this Lease, upon completion of any Alterations, Tenant agrees to cause a Notice of Completion to be recorded in the office of the
Recorder of the County of Marin in accordance with Section 3093 of the Civil Code of the State of California or any successor statute, and Tenant shall deliver to the Project management office (A) a reproducible print copy, and (B) an
electronic CAD file, of the “as built” drawings of the Alterations as well as all permits, approvals and other documents issued by any governmental agency in connection with the Alterations. Based upon such “as built”
drawings and other documents provided by Tenant, Landlord shall, at Tenant’s expense, update Landlord’s “As-Built Floor Master Plans,” including updated vellums and electronic CAD files. As used in this Lease, the
“As-Built Floor Master Plans” means (i) the “Architectural Partition Plan,” and (ii) the following engineered plans: (a) “Lighting Plan,” (b) “Power Plan,” (c) “Mechanical
Plan,” (d) 

  

					
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“Plumbing Plan,” (e) “Fire Sprinkler Plan, and (f) “Fire/Life Safety Plan.” The current version of such As-Built Floor Master Plans, which may be modified by
Landlord from time-to-time, shall be made available to Tenant upon Tenant’s request, at Landlord’s expense. 
 8.3
Payment for Improvements. If payment is made directly to contractors, Tenant shall comply with Landlord’s requirements for final lien releases and waivers in connection with Tenant’s payment for work to contractors. Whether
or not Tenant orders any work directly from Landlord, Tenant shall pay to Landlord two (2) percent of the hard costs of such work, subject to a ceiling of $1.50 per square foot, to compensate Landlord for all overhead, general conditions, fees
and other costs and expenses arising from Landlord’s involvement with such work. 
 8.4 Construction
Insurance. In addition to the requirements of Article 10 of this Lease, in the event that Tenant makes any Alterations, prior to the commencement of such Alterations, Tenant shall provide Landlord with evidence that Tenant carries
“Builder’s All Risk” insurance, or comparable, in an amount approved by Landlord covering the construction of such Alterations, and such other insurance as Landlord may require, it being understood and agreed that all of such
Alterations shall be insured by Tenant pursuant to Article 10 of this Lease immediately upon completion thereof. In addition, Landlord may, in its discretion, require Tenant to obtain a lien and completion bond or some alternate form of
security satisfactory to Landlord in an amount sufficient to ensure the lien-free completion of such Alterations and naming Landlord as a co-obligee, in any instance where the projected cost of the proposed Alterations is in excess of $50,000.

 8.5 Landlord’s Property. All Alterations which may be installed or placed in or about the Premises, from
time to time, shall be at the sole cost of Tenant and shall be and become the property of Landlord, except that Tenant may remove any Alterations which Tenant can substantiate to Landlord have not been paid for with any Tenant improvement allowance
funds provided to Tenant by Landlord, provided Tenant repairs any damage to the Premises and Building caused by such removal and returns the affected portion of the Premises to a building standard tenant improved condition as determined by Landlord.
Furthermore, Landlord may, by written notice to Tenant given concurrently with giving Landlord’s consent, require Tenant, at Tenant’s expense, to remove at the end of the Term the following Tenant Improvements and any Alterations which in
Landlord’s reasonable judgment are of a nature that would require removal and repair costs that are materially in excess of the removal and repair costs associated with standard office improvements: laboratory improvements, any exercise
facility, and any cafeteria (collectively referred to as “Required Removables”), and to repair any damage to the Premises and Building caused by such removal. If Tenant fails to complete such removal and/or to repair any damage
caused by the removal of any Alterations, then at Landlord’s option, either (A) Tenant shall be deemed to be holding over in the Premises and Rent shall continue to accrue in accordance with the terms of Article 16, below, until such
work shall be completed, or (B) Landlord may do so and may charge the cost thereof to Tenant. Tenant hereby protects, defends, indemnifies and holds Landlord harmless from any liability, cost, obligation, expense or claim of lien in any manner
relating to the installation, placement, and removal or financing of any such Alterations in, on or about the Premises, which obligations of Tenant shall survive the expiration or earlier termination of this Lease. Tenant’s removal obligations
with respect to the Tenant Improvements are set forth in the Tenant Work Letter. 

  

					
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 ARTICLE 9 
 COVENANT AGAINST LIENS 
 Tenant shall keep the Project and Premises
free from any liens or encumbrances arising out of the work performed, materials furnished or obligations incurred by or on behalf of Tenant, and shall protect, defend, indemnify and hold Landlord harmless from and against any claims, liabilities,
judgments or costs (including, without limitation, reasonable attorneys’ fees and costs) arising out of same or in connection therewith. Tenant shall give Landlord notice at least twenty (20) days prior to the commencement of any such work
on the Premises (or such additional time as may be necessary under applicable laws) to afford Landlord the opportunity of posting and recording appropriate notices of non-responsibility. Tenant shall remove any such lien or encumbrance by bond or
otherwise within five (5) days after notice by Landlord, and if Tenant shall fail to do so, Landlord may pay the amount necessary to remove such lien or encumbrance, without being responsible for investigating the validity thereof. The amount
so paid shall be deemed Additional Rent under this Lease payable upon demand, without limitation as to other remedies available to Landlord under this Lease. Nothing contained in this Lease shall authorize Tenant to do any act which shall subject
Landlord’s title to the Building or Premises to any liens or encumbrances whether claimed by operation of law or express or implied contract. Any claim to a lien or encumbrance upon the Building or Premises arising in connection with any such
work or respecting the Premises not performed by or at the request of Landlord shall be null and void, or at Landlord’s option shall attach only against Tenant’s interest in the Premises and shall in all respects be subordinate to
Landlord’s title to the Project, Building and Premises. 
 ARTICLE 10 

INSURANCE 
 10.1 Indemnification and Waiver. Tenant hereby assumes all risk of damage to property or injury to persons in, upon or about the Premises from any cause whatsoever (including, but not
limited to, any personal injuries resulting from a slip and fall in, upon or about the Premises) and agrees that Landlord, its partners, subpartners and their respective officers, agents, servants, employees, and independent contractors
(collectively, “Landlord Parties”) shall not be liable for, and are hereby released from any responsibility for, any damage either to person or property or resulting from the loss of use thereof, which damage is sustained by Tenant
or by other persons claiming through Tenant. Tenant shall indemnify, defend, protect, and hold harmless the Landlord Parties from any and all loss, cost, damage, expense and liability (including without limitation court costs and reasonable
attorneys’ fees) incurred in connection with or arising from any cause in, on or about the Premises, any violation of any of the requirements, ordinances, statutes, regulations or other laws, including, without limitation, any environmental
laws, any acts, omissions or negligence of Tenant or of any person claiming by, through or under Tenant, or of the contractors, agents, servants, employees, invitees, guests or licensees of Tenant or any such person, in, on or about the Project or
any breach of the terms of this Lease, either prior to, during, or after the expiration of the Lease Term, provided that the terms of the foregoing indemnity shall not apply to the gross negligence or willful misconduct of Landlord or any of the
Landlord Parties. Should Landlord be named as a defendant in any suit brought against Tenant in connection with or arising out of Tenant’s occupancy of the Premises, 

  

					
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Tenant shall pay to Landlord its costs and expenses incurred in such suit, including without limitation, its actual professional fees such as appraisers’, accountants’ and
attorneys’ fees. Further, Tenant’s agreement to indemnify Landlord pursuant to this Section 10.1 is not intended and shall not relieve any insurance carrier of its obligations under policies required to be carried by Tenant pursuant
to the provisions of this Lease, to the extent such policies cover the matters subject to Tenant’s indemnification obligations; nor shall they supersede any inconsistent agreement of the parties set forth in any other provision of this Lease.
The provisions of this Section 10.1 shall survive the expiration or sooner termination of this Lease with respect to any claims or liability arising in connection with any event occurring prior to such expiration or termination. 

10.2 Tenant’s Compliance With Landlord’s Fire and Casualty Insurance. Tenant shall, at Tenant’s expense,
comply with all insurance company requirements pertaining to the use of the Premises. If Tenant’s conduct or use of the Premises causes any increase in the premium for such insurance policies then Tenant shall reimburse Landlord for any such
increase. Tenant, at Tenant’s expense, shall comply with all rules, orders, regulations or requirements of the American Insurance Association (formerly the National Board of Fire Underwriters) and with any similar body. 

10.3 Tenant’s Insurance. Tenant shall maintain the following coverages in the following amounts. 

10.3.1 Commercial General Liability Insurance covering the insured against claims of bodily injury, personal injury and property damage
(including loss of use thereof) arising out of Tenant’s operations, and contractual liabilities (covering the performance by Tenant of its indemnity agreements) including a Broad Form endorsement covering the insuring provisions of this Lease
and the performance by Tenant of the indemnity agreements set forth in Section 10.1 of this Lease, for limits of liability not less than: 
  

			
	 Bodily Injury and

Property Damage Liability
	  	 $5,000,000 each occurrence

$5,000,000 annual aggregate

		
	 Personal Injury Liability
	  	 $5,000,000 each occurrence

$5,000,000 annual aggregate
 0% Insured’s
participation

 10.3.2 Physical Damage Insurance covering (i) all office furniture, business and trade fixtures,
office equipment, free-standing cabinet work, movable partitions, merchandise and all other items of Tenant’s property on the Premises installed by, for, or at the expense of Tenant, (ii) the “Tenant Improvements,” as that term
is defined in Section 2.1 of the Tenant Work Letter, and any other improvements which exist in the Premises as of the Lease Commencement Date (excluding the Base Building) (the “Original Improvements”), and (iii) all other
improvements, alterations and additions to the Premises. Such insurance shall be written on an “all risks” of physical loss or damage basis, for the full replacement cost value (subject to reasonable deductible amounts) new without
deduction for depreciation of the covered items and in amounts that meet any co-insurance clauses of the policies of insurance and shall include coverage for damage or other loss caused by fire or other peril including, but not

  

					
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limited to, vandalism and malicious mischief, theft, water damage of any type, including sprinkler leakage, bursting or stoppage of pipes, and explosion, and providing business interruption
coverage for a period of one year. 
 10.3.3 Worker’s Compensation and Employer’s Liability or other similar insurance
pursuant to all applicable state and local statutes and regulations. 
 10.4 Form of Policies. The minimum limits
of policies of insurance required of Tenant under this Lease shall in no event limit the liability of Tenant under this Lease. Such insurance shall (i) name Landlord, Landlord’s lender, and any other party the Landlord so specifies, as an
additional insured, including Landlord’s managing agent, if any; (ii) specifically cover the liability assumed by Tenant under this Lease, including, but not limited to, Tenant’s obligations under Section 10.1 of this Lease;
(iii) be issued by an insurance company having a rating of not less than A-VIII in Best’s Insurance Guide or which is otherwise acceptable to Landlord and licensed to do business in the State of California; (iv) be primary insurance
as to all claims thereunder and provide that any insurance carried by Landlord is excess and is non-contributing with any insurance requirement of Tenant; and (v) be in form and content reasonably acceptable to Landlord. In the event that any
insurance required of Tenant under the Lease is cancelled or modified, then, within three (3) business days’ of Tenant’s receipt of notice of cancellation or modification, Tenant shall give Landlord notice of such cancellation or
modification. Tenant shall deliver said policy or policies or certificates thereof to Landlord on or before the Lease Commencement Date and at least thirty (30) days before the expiration dates thereof. In the event Tenant shall fail to procure
such insurance, or to deliver such policies or certificate, Landlord may, at its option, procure such policies for the account of Tenant, and the cost thereof shall be paid to Landlord within five (5) days after delivery to Tenant of bills
therefor. 
 10.5 Subrogation. Landlord and Tenant intend that their respective property loss risks shall be borne
by reasonable insurance carriers to the extent above provided, and Landlord and Tenant hereby agree to look solely to, and seek recovery only from, their respective insurance carriers in the event of a property loss to the extent that such coverage
is agreed to be provided hereunder. The parties each hereby waive all rights and claims against each other for such losses, and waive all rights of subrogation of their respective insurers, provided such waiver of subrogation shall not affect the
right to the insured to recover thereunder. The parties agree that their respective insurance policies are now, or shall be, endorsed such that the waiver of subrogation shall not affect the right of the insured to recover thereunder, so long as no
material additional premium is charged therefor. 
 10.6 Additional Insurance Obligations. Tenant shall carry and
maintain during the entire Lease Term, at Tenant’s sole cost and expense, increased amounts of the insurance required to be carried by Tenant pursuant to this Article 10 and such other reasonable types of insurance coverage and in such
reasonable amounts covering the Premises and Tenant’s operations therein, as may be reasonably requested by Landlord or Landlord’s lenders, if any. 
 10.7 Landlord’s Insurance. So long as the same is available at commercially reasonable rates, Landlord shall maintain so called “Special form Causes of Loss property insurance on
the Building at replacement cost value, as reasonably estimated by Landlord. 

  

					
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 ARTICLE 11 
 DAMAGE AND DESTRUCTION 
 11.1 Repair of Damage to Premises by
Landlord. Tenant shall promptly notify Landlord of any damage to the Premises resulting from fire or any other casualty. Within ninety (90) days of such casualty Landlord shall give to Tenant a notice estimating the date upon which the
Landlord’s repair shall be complete (the “Landlord Repair Notice”). The ninety (90) day notice period in the preceding sentence may be extended by Landlord for an additional thirty (30) days if by the end of
the ninety (90) day notice period Landlord has not received the information required to issue the Landlord Repair Notice and so notifies Tenant. If the Premises or any Common Areas serving or providing access to the Premises shall be damaged by
fire or other casualty, Landlord shall promptly and diligently, subject to reasonable delays for insurance adjustment or other matters beyond Landlord’s reasonable control, and subject to all other terms of this Article 11, restore the
Base Building and such Common Areas. Such restoration shall be to substantially the same condition of the Base Building and the Common Areas prior to the casualty, except for modifications required by zoning and building codes and other laws or by
the holder of a mortgage on the Building or Project or any other modifications to the Common Areas deemed desirable by Landlord, provided that access to the Premises and any common restrooms serving the Premises shall not be materially impaired.
Upon the occurrence of any damage to the Premises, upon notice (the “Landlord Repair Notice”) to Tenant from Landlord, Tenant shall assign to Landlord (or to any party designated by Landlord) all insurance proceeds payable to Tenant
under Tenant’s insurance required under Section 10.3 of this Lease, and Landlord shall repair any injury or damage to the Tenant Improvements and the Original Improvements installed in the Premises and shall return such Tenant Improvements
and Original Improvements to their original condition; provided that if the cost of such repair by Landlord exceeds the amount of insurance proceeds received by Landlord from Tenant’s insurance carrier, as assigned by Tenant, the cost of such
repairs shall be paid by Tenant to Landlord prior to Landlord’s commencement of repair of the damage, provided Tenant has been given satisfactory evidence of their costs. In the event that Landlord does not deliver the Landlord Repair Notice
within one hundred twenty (120) days following the date the casualty becomes known to Landlord, Tenant shall, at its sole cost and expense, repair any injury or damage to the Tenant Improvements and the Original Improvements installed in the
Premises and shall return such Tenant Improvements and Original Improvements to their original condition. Whether or not Landlord delivers a Landlord Repair Notice, prior to the commencement of construction, Tenant shall submit to Landlord, for
Landlord’s review and approval, all plans, specifications and working drawings relating thereto, and Landlord shall select the contractors to perform such improvement work. Landlord shall not be liable for any inconvenience or annoyance to
Tenant or its visitors, or injury to Tenant’s business resulting in any way from such damage or the repair thereof; provided however, that if such fire or other casualty shall have damaged the Premises or Common Areas necessary to Tenant’s
occupancy, Landlord shall allow Tenant a proportionate abatement of Rent to the extent Landlord is reimbursed from the proceeds of rental interruption insurance purchased by Landlord as part of Operating Expenses, during the time and to the extent
the Premises are unfit for occupancy for the purposes permitted under this Lease, and not occupied by Tenant as a result thereof; provided, further, however, that if the damage or destruction is due to the negligence or wilful misconduct of Tenant
or any of its agents, employees, contractors, invitees or guests, Tenant shall be responsible for any reasonable, 

  

					
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applicable insurance deductible (which shall be payable to Landlord upon demand) and there shall be no rent abatement. In the event that Landlord shall not deliver the Landlord Repair Notice,
Tenant’s right to rent abatement pursuant to the preceding sentence shall terminate as of the date which is reasonably determined by Landlord to be the date Tenant should have completed repairs to the Premises assuming Tenant used reasonable
due diligence in connection therewith. 
 11.2 Termination Options. Notwithstanding the terms of Section 11.1
of this Lease, Landlord may elect not to rebuild and/or restore the Premises, Building and/or Project, and instead terminate this Lease, by notifying Tenant in writing of such termination within thirty (30) days after the date of the Landlord
Repair Notice, such notice to include a termination date giving Tenant sixty (60) days to vacate the Premises, but Landlord may so elect only if the Building or Project shall be damaged by fire or other casualty or cause, whether or not the
Premises are affected, and one or more of the following conditions is present: (i) in Landlord’s reasonable judgment, repairs cannot reasonably be completed within one (1) year after the date of the Landlord Repair Notice (when such
repairs are made without the payment of overtime or other premiums); (ii) the holder of any mortgage on the Building or Project or ground lessor with respect to the Building or Project shall require that the insurance proceeds or any portion
thereof be used to retire the mortgage debt, or shall terminate the ground lease, as the case may be; (iii) the damage is not fully covered by Landlord’s insurance policies (unless Landlord has failed to maintain the policies required by
this Lease); or (iv) the damage occurs during the last twelve (12) months of the Lease Term. 
 Notwithstanding the
terms of Section 11.1 of this Lease, Tenant may terminate this Lease, by notifying Landlord in writing of such termination within thirty (30) days after the date of Landlord’s notice required in the preceding paragraph, such notice to
include a termination date giving Tenant sixty (60) days to vacate the Premises, if the Building shall be damaged by fire or other casualty or cause, and one or more of the following conditions is present: (iv) in Landlord’s
reasonable judgment, repairs cannot reasonably be completed within one (1) year after the date of the Landlord Repair Notice (when such repairs are made without the payment of overtime or other premiums); or (v) the damage occurs during
the last twelve (12) months of the Lease Term. In addition, Tenant may terminate the Lease by giving written notice to Landlord if Landlord shall have failed to complete the restoration as required above within ninety (90) days following
the estimated restoration date set forth in the Landlord Repair Notice. 
 11.3 Waiver of Statutory Provisions.
The provisions of this Lease, including this Article 11, constitute an express agreement between Landlord and Tenant with respect to any and all damage to, or destruction of, all or any part of the Premises, the Building or the Project, and any
statute or regulation of the State of California, including, without limitation, Sections 1932(2) and 1933(4) of the California Civil Code, with respect to any rights or obligations concerning damage or destruction in the absence of an express
agreement between the parties, and any other statute or regulation, now or hereafter in effect, shall have no application to this Lease or any damage or destruction to all or any part of the Premises, the Building or the Project. 

  

					
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 ARTICLE 12 
 NONWAIVER 
 No provision of this Lease shall be deemed waived by
either party hereto unless expressly waived in a writing signed thereby. The waiver by either party hereto of any breach of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of same or any
other term, covenant or condition herein contained. The subsequent acceptance of Rent hereunder by Landlord shall not be deemed to be a waiver of any preceding breach by Tenant of any term, covenant or condition of this Lease, other than the failure
of Tenant to pay the particular Rent so accepted, regardless of Landlord’s knowledge of such preceding breach at the time of acceptance of such Rent. No acceptance of a lesser amount than the Rent herein stipulated shall be deemed a waiver of
Landlord’s right to receive the full amount due, nor shall any endorsement or statement on any check or payment or any letter accompanying such check or payment be deemed an accord and satisfaction, and Landlord may accept such check or payment
without prejudice to Landlord’s right to recover the full amount due. No receipt of monies by Landlord from Tenant after the termination of this Lease shall in any way alter the length of the Lease Term or of Tenant’s right of possession
hereunder, or after the giving of any notice shall reinstate, continue or extend the Lease Term or affect any notice given Tenant prior to the receipt of such monies, it being agreed that after the service of notice or the commencement of a suit, or
after final judgment for possession of the Premises, Landlord may receive and collect any Rent due, and the payment of said Rent shall not waive or affect said notice, suit or judgment. 

ARTICLE 13 

CONDEMNATION 
 If the whole or any part of the Premises, Building or Project shall be taken by power of eminent domain or condemned by any competent authority for any public or quasi-public use or purpose, or if any
adjacent property or street shall be so taken or condemned, or reconfigured or vacated by such authority in such manner as to require the use, reconstruction or remodeling of any part of the Premises, Building or Project, or if Landlord shall grant
a deed or other instrument in lieu of such taking by eminent domain or condemnation, Landlord shall have the option to terminate this Lease effective as of the date possession is required to be surrendered to the authority. If more than twenty-five
percent (25%) of the rentable square feet of the Premises is taken, or if access to the Premises is substantially impaired, in each case for a period in excess of one hundred eighty (180) days, Tenant shall have the option to terminate
this Lease effective as of the date possession is required to be surrendered to the authority. Tenant shall not because of such taking assert any claim against Landlord or the authority for any compensation because of such taking and Landlord shall
be entitled to the entire award or payment in connection therewith, except that Tenant shall have the right to file any separate claim available to Tenant for any taking of Tenant’s personal property and fixtures belonging to Tenant and
removable by Tenant upon expiration of the Lease Term pursuant to the terms of this Lease, and for moving expenses, so long as such claims do not diminish the award available to Landlord, its ground lessor with respect to the Building or Project or
its mortgagee, and such claim is payable separately to Tenant. All Rent shall be apportioned as of the date of such termination. If any 

  

					
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part of the Premises shall be taken, and this Lease shall not be so terminated, the Rent shall be proportionately abated. Tenant hereby waives any and all rights it might otherwise have pursuant
to Section 1265.130 of The California Code of Civil Procedure. Notwithstanding anything to the contrary contained in this Article 13, in the event of a temporary taking of all or any portion of the Premises for a period of one hundred and
eighty (180) days or less, then this Lease shall not terminate but the Base Rent and the Additional Rent shall be abated for the period of such taking in proportion to the ratio that the amount of rentable square feet of the Premises taken
bears to the total rentable square feet of the Premises. Landlord shall be entitled to receive the entire award made in connection with any such temporary taking. 
 ARTICLE 14 
 ASSIGNMENT AND SUBLETTING 

14.1 Transfers. Tenant shall not, without the prior written consent of Landlord, assign, mortgage, pledge, hypothecate,
encumber, or permit any lien to attach to, or otherwise transfer, this Lease or any interest hereunder, permit any assignment, or other transfer of this Lease or any interest hereunder by operation of law, sublet the Premises or any part thereof, or
enter into any license or concession agreements or otherwise permit the occupancy or use of the Premises or any part thereof by any persons other than Tenant and its employees and contractors (all of the foregoing are hereinafter sometimes referred
to collectively as “Transfers” and any person to whom any Transfer is made or sought to be made is hereinafter sometimes referred to as a “Transferee”). If Tenant desires Landlord’s consent to any Transfer,
Tenant shall notify Landlord in writing, which notice (the “Transfer Notice”) shall include (i) the proposed effective date of the Transfer, which shall not be less than thirty (30) days nor more than one hundred eighty
(180) days after the date of delivery of the Transfer Notice, (ii) a description of the portion of the Premises to be transferred (the “Subject Space”), (iii) all of the terms of the proposed Transfer and the
consideration therefor, including calculation of the “Transfer Premium”, as that term is defined in Section 14.3 below, in connection with such Transfer, the name and address of the proposed Transferee, and an executed copy of all
documentation effectuating the proposed Transfer, including all operative documents to evidence such Transfer and all agreements incidental or related to such Transfer, provided that Landlord shall have the right to require Tenant to utilize
Landlord’s standard form of consent document in connection with the consent of Landlord to a Transfer, (iv) current financial statements of the proposed Transferee certified by an officer, partner or owner thereof, business credit and
personal references and history of the proposed Transferee and any other information required by Landlord which will enable Landlord to determine the financial responsibility, character, and reputation of the proposed Transferee, nature of such
Transferee’s business and proposed use of the Subject Space and (v) an executed estoppel certificate from Tenant in the form attached hereto as Exhibit E. Any Transfer for which consent is required made without
Landlord’s prior written consent shall, at Landlord’s option, be null, void and of no effect, and shall, at Landlord’s option, constitute a Default by Tenant under this Lease. Whether or not Landlord consents to any proposed Transfer,
Tenant shall pay Landlord’s reasonable review and processing fees, as well as any reasonable professional fees (including, without limitation, attorneys’, accountants’, architects’, engineers’ and consultants’ fees)
incurred by Landlord, which shall not exceed $10,000.00, within thirty (30) days after written request by Landlord. 

  

					
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 14.2 Landlord’s Consent. Landlord shall not unreasonably withhold its
consent to any proposed Transfer of the Subject Space to the Transferee on the terms specified in the Transfer Notice. Without limitation as to other reasonable grounds for withholding consent, the parties hereby agree that it shall be reasonable
under this Lease and under any applicable law for Landlord to withhold consent to any proposed Transfer where one or more of the following apply: 
 14.2.1 The Transferee is of a character or reputation or engaged in a business which is not consistent with the quality of the Building or the Project, or would be a significantly less prestigious
occupant of the Building than Tenant; 
 14.2.2 The Transferee intends to use the Subject Space for purposes which are not
permitted under this Lease; 
 14.2.3 The Transferee is either a governmental agency or instrumentality thereof; 

14.2.4 The Transfer occurs during the period from the Lease Commencement Date until the earlier of (i) one (1) year after
Tenant’s occupancy of at least 130,000 rentable square feet in the Project or March 1, 2014, or (ii) the date at least ninety-five percent (95%) of the rentable square feet of the Project is leased, and the rent charged by Tenant
to such Transferee during the term of such Transfer (the “Transferee’s Rent”), is less than ninety-five percent (95%) of the starting rent being obtained by landlords of comparable space in Comparable Buildings within the
twelve (12) months prior to the time of such Transfer for a comparable term (the “Quoted Rent”). In the event there are comparable space lease transactions within the six (6) months prior to such Transfer, those
transactions shall be considered first; 
 14.2.5 The Transferee is not a party of reasonable financial worth and/or financial
stability in light of the responsibilities to be undertaken in connection with the Transfer on the date consent is requested; 

14.2.6 The proposed Transfer would cause a violation of another lease for space in the Project, or would give an occupant of the Project
a right to cancel its lease; 
 14.2.7 The terms of the proposed Transfer will allow the Transferee to exercise a right of
renewal, right of expansion, right of first offer, or other similar right held by Tenant (or will allow the Transferee to occupy space leased by Tenant pursuant to any such right); or 

14.2.8 At the time of the proposed Transfer, Landlord has comparable space available for lease in the Project and either the proposed
Transferee, or any person or entity which directly or indirectly, controls, is controlled by, or is under common control with, the proposed Transferee, (i) occupies space in the Project at the time of the request for consent, or (ii) is
negotiating with Landlord to lease space in the Project at such time, or (iii) has negotiated with Landlord during the twelve (12)-month period immediately preceding the Transfer Notice. For the purposed of this Section 14.2.8, the term
“comparable space” means space that is substantially the same size, which has or will have the same quality of finish and which is or will be of the same type (office, lab, etc.) as the Subject Space. 

  

					
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 If Landlord consents to any Transfer pursuant to the terms of this Section 14.2 (and
does not exercise any recapture rights Landlord may have under Section 14.4 of this Lease), Tenant may within six (6) months after Landlord’s consent, but not later than the expiration of said six-month period, enter into such
Transfer of the Premises or portion thereof, upon substantially the same terms and conditions as are set forth in the Transfer Notice furnished by Tenant to Landlord pursuant to Section 14.1 of this Lease, provided that if there are any changes
in the terms and conditions from those specified in the Transfer Notice (i) such that Landlord would initially have been entitled to refuse its consent to such Transfer under this Section 14.2, or (ii) which would cause the proposed
Transfer to be more favorable to the Transferee than the terms set forth in Tenant’s original Transfer Notice, Tenant shall again submit the Transfer to Landlord for its approval and other action under this Article 14 (including
Landlord’s right of recapture, if any, under Section 14.4 of this Lease). Notwithstanding anything to the contrary in this Lease, if Tenant or any proposed Transferee claims that Landlord has unreasonably withheld or delayed its consent
under Section 14.2 or otherwise has breached or acted unreasonably under this Article 14, their sole remedies shall be a declaratory judgment and an injunction for the relief sought without any monetary damages, and Tenant hereby waives
all other remedies, including, without limitation, any right at law or equity to terminate this Lease, on its own behalf and, to the extent permitted under all applicable laws, on behalf of the proposed Transferee. Tenant shall indemnify, defend and
hold harmless Landlord from any and all liability, losses, claims, damages, costs, expenses, causes of action and proceedings involving any third party or parties (including without limitation Tenant’s proposed subtenant or assignee) who claim
they were damaged by Landlord’s wrongful withholding or conditioning of Landlord’s consent. 
 14.3 Transfer
Premium. If Landlord consents to a Transfer, as a condition thereto which the parties hereby agree is reasonable, Tenant shall pay to Landlord fifty percent (50%) of any “Transfer Premium,” as that term is defined in this
Section 14.3, received by Tenant from such Transferee. “Transfer Premium” shall mean all rent, additional rent or other consideration payable by such Transferee in connection with the Transfer in excess of the Rent and
Additional Rent payable by Tenant under this Lease during the term of the Transfer on a per rentable square foot basis if less than all of the Premises is transferred, after deducting the reasonable expenses incurred by Tenant for (i) any free
base rent reasonably provided to the Transferee, (ii) any brokerage commissions, (iii) legal fees, (iv) tenant improvement costs required by the Transferee, and (v) any legal or other fees payable to Landlord in connection with
the Transfer, all of which shall be amortized on a straight-line basis over the remaining term of the Lease, or sublease, as the case may be. “Transfer Premium” shall also include, but not be limited to, key money, bonus money or other
cash consideration paid by Transferee to Tenant in connection with such Transfer, any debt relief benefiting Tenant in connection with such Transfer, and any payment in excess of fair market value for services rendered by Tenant to Transferee or for
assets, fixtures, inventory, equipment, or furniture transferred by Tenant to Transferee in connection with such Transfer. In the calculations of the Rent (as it relates to the Transfer Premium calculated under this Section 14.3), and the
Transferee’s Rent and Quoted Rent under Section 14.2 of this Lease, the Rent paid during each annual period for the Subject Space, and the Transferee’s Rent and the Quoted Rent, shall be computed after adjusting such rent to the
actual effective rent to be paid, taking into consideration any and all leasehold concessions 

  

					
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granted in connection therewith, including, but not limited to, any rent credit and tenant improvement allowance. For purposes of calculating any such effective rent all such concessions shall be
amortized on a straight-line basis over the relevant term. 
 14.4 Landlord’s Option as to Subject Space.
Notwithstanding anything to the contrary contained in this Article 14, Landlord shall have the option, by giving written notice to Tenant within thirty (30) days after receipt of any Transfer Notice, to recapture the Subject Space. Such
recapture notice shall cancel and terminate this Lease with respect to the Subject Space as of the date stated in the Transfer Notice as the effective date of the proposed Transfer until the last day of the term of the Transfer as set forth in the
Transfer Notice (or at Landlord’s option, shall cause the Transfer to be made to Landlord or its agent, in which case the parties shall execute the Transfer documentation promptly thereafter). In the event of a recapture by Landlord, if this
Lease shall be canceled with respect to less than the entire Premises, the Rent reserved herein shall be prorated on the basis of the number of rentable square feet retained by Tenant in proportion to the number of rentable square feet contained in
the Premises, and this Lease as so amended shall continue thereafter in full force and effect, and upon request of either party, the parties shall execute written confirmation of the same. If Landlord declines, or fails to elect in a timely manner
to recapture the Subject Space under this Section 14.4, then, provided Landlord has consented to the proposed Transfer, Tenant shall be entitled to proceed to transfer the Subject Space to the proposed Transferee, subject to provisions of this
Article 14. 
 14.5 Effect of Transfer. If Landlord consents to a Transfer, (i) the terms and conditions
of this Lease shall in no way be deemed to have been waived or modified, (ii) such consent shall not be deemed consent to any further Transfer by either Tenant or a Transferee, (iii) Tenant shall deliver to Landlord, promptly after
execution, an original executed copy of all documentation pertaining to the Transfer in form reasonably acceptable to Landlord, (iv) Tenant shall furnish upon Landlord’s request a complete statement, certified by an independent certified
public accountant, or Tenant’s chief financial officer, setting forth in detail the computation of any Transfer Premium Tenant has derived and shall derive from such Transfer, and (v) no Transfer relating to this Lease or agreement entered
into with respect thereto, whether with or without Landlord’s consent, shall relieve Tenant or any guarantor of the Lease from any liability under this Lease, including, without limitation, in connection with the Subject Space. Landlord or its
authorized representatives shall have the right at all reasonable times to audit the books, records and papers of Tenant relating to any Transfer, and shall have the right to make copies thereof. If the Transfer Premium respecting any Transfer shall
be found understated, Tenant shall, within thirty (30) days after demand, pay the deficiency, and if understated by more than two percent (2%), Tenant shall pay Landlord’s costs of such audit. 

14.6 Additional Transfers. For purposes of this Lease, the term “Transfer” shall also include, except as
otherwise described in Section 14.8, (i) if Tenant is a partnership, the withdrawal or change, voluntary, involuntary or by operation of law, of twenty-five percent (25%) or more of the partners, or transfer of twenty-five percent
(25%) or more of partnership interests, within a twelve (12)-month period, or the dissolution of the partnership without immediate reconstitution thereof, and (ii) if Tenant is a closely held corporation (i.e., whose stock is not publicly
held and not traded through an exchange or over the counter), (A) the dissolution, merger, consolidation or other reorganization of Tenant or (B) the sale or other transfer of an aggregate of twenty-five percent (25%) or more of the
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(other than to immediate family members by reason of gift or death), within a twelve (12)-month period, or (C) the sale, mortgage, hypothecation or pledge of an aggregate of twenty-five
percent (25%) or more of the value of the unencumbered assets of Tenant within a twelve (12)-month period. 
 14.7
Occurrence of Default. Any Transfer hereunder shall be subordinate and subject to the provisions of this Lease, and if this Lease shall be terminated during the term of any Transfer, Landlord shall have the right to: (i) treat
such Transfer as cancelled and repossess the Subject Space by any lawful means, or (ii) require that such Transferee attorn to and recognize Landlord as its landlord under any such Transfer. If Tenant shall be in Default under this Lease,
Landlord is hereby irrevocably authorized, as Tenant’s agent and attorney-in-fact, to direct any Transferee to make all payments under or in connection with the Transfer directly to Landlord (which Landlord shall apply towards Tenant’s
obligations under this Lease) until such Event of Default is cured. Such Transferee shall rely on any representation by Landlord that Tenant is in Default hereunder, without any need for confirmation thereof by Tenant. Upon any assignment, the
assignee shall assume in writing all obligations and covenants of Tenant thereafter to be performed or observed under this Lease. No collection or acceptance of rent by Landlord from any Transferee shall be deemed a waiver of any provision of this
Article 14 or the approval of any Transferee or a release of Tenant from any obligation under this Lease, whether theretofore or thereafter accruing. In no event shall Landlord’s enforcement of any provision of this Lease against any
Transferee be deemed a waiver of Landlord’s right to enforce any term of this Lease against Tenant or any other person. If Tenant’s obligations hereunder have been guaranteed, Landlord’s consent to any Transfer shall not be effective
unless the guarantor also consents to such Transfer. 
 14.8 Non-Transfers. Notwithstanding anything to the
contrary contained in this Lease, neither (i) an assignment to a transferee of all or substantially all of the assets and liabilities of Tenant, (ii) an assignment of the Premises to a transferee which is the resulting entity of a merger
or consolidation of Tenant with another entity, nor (iii) an assignment or subletting of all or a portion of the Premises to an affiliate (an “Affiliate”) of Tenant (an entity which is controlled by, controls, or is under common
control with, Tenant), shall be deemed a Transfer under Article 14 of this Lease, provided that within fifteen (15) days after the effective date of the Transfer, Tenant notifies Landlord of any such assignment or sublease and supplies Landlord
with any documents or information reasonably requested by Landlord regarding such transfer or transferee as set forth in items (i) through (iii) above, and provided that such assignment or sublease is not a subterfuge by Tenant to avoid
its obligations under this Lease. “Control,” as used in this Section 14.7, shall mean the ownership, directly or indirectly, of at least fifty-one percent (51%) of the voting securities of, or possession of the right to vote, in
the ordinary direction of its affairs, of at least fifty-one percent (51%) of the voting interest in, any person or entity. 

ARTICLE 15  
 SURRENDER OF PREMISES; OWNERSHIP AND REMOVAL OF TRADE FIXTURES 

15.1 Surrender of Premises. No act or thing done by Landlord or any agent or employee of Landlord during the Lease Term
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Landlord of a surrender of the Premises unless such intent is specifically acknowledged in writing by Landlord. The delivery of keys to the Premises to Landlord or any agent or employee of
Landlord shall not constitute a surrender of the Premises or effect a termination of this Lease, whether or not the keys are thereafter retained by Landlord, and notwithstanding such delivery Tenant shall be entitled to the return of such keys at
any reasonable time upon request until this Lease shall have been properly terminated. The voluntary or other surrender of this Lease by Tenant, whether accepted by Landlord or not, or a mutual termination hereof, shall not work a merger, and at the
option of Landlord shall operate as an assignment to Landlord of all subleases or subtenancies affecting the Premises or terminate any or all such sublessees or subtenancies. 
 15.2 Removal of Tenant Property by Tenant. Upon the expiration of the Lease Term, or upon any earlier termination of this Lease, Tenant shall, subject to the provisions of this
Article 15, quit and surrender possession of the Premises to Landlord in as good order and condition as when Tenant took possession and as thereafter improved by Landlord and/or Tenant, reasonable wear and tear and repairs which are
specifically made the responsibility of Landlord hereunder excepted. Upon such expiration or termination, Tenant shall, without expense to Landlord, remove or cause to be removed from the Premises all debris and rubbish, and such items of furniture,
equipment, business and trade fixtures, free-standing cabinet work, movable partitions and other articles of personal property owned by Tenant or installed or placed by Tenant at its expense in the Premises, and such similar articles of any other
persons claiming under Tenant, as Landlord may, in its sole discretion, require to be removed (the notification of which may be provided to Tenant either prior to or following the expiration or earlier termination of this Lease), and Tenant shall
repair at its own expense all damage to the Premises and Building resulting from such removal. 
 ARTICLE 16 

 HOLDING OVER 
 If Tenant holds over after the expiration of the Lease Term or earlier termination thereof, with or without the express or implied consent of Landlord, such tenancy shall be from month-to-month only, and
shall not constitute a renewal hereof or an extension for any further term, and in such case Base Rent shall be payable for the first sixty (60) days at a monthly rate equal to 150% of the Rent applicable during the last rental period of the
Lease Term under this Lease, and thereafter at a monthly rate equal to 200% of the Base Rent applicable during the last rental period of the Lease Term under this Lease. Such month-to-month tenancy shall be subject to every other applicable term,
covenant and agreement contained herein. For purposes of this Article 16, a holding over shall include Tenant’s remaining in the Premises after the expiration or earlier termination of the Lease Term, as required pursuant to the terms of
Section 8.5, above, to remove any Alterations or Above Building Standard Tenant Improvements located within the Premises and replace the same with Building Standard Tenant Improvements. Nothing contained in this Article 16 shall be
construed as consent by Landlord to any holding over by Tenant, and Landlord expressly reserves the right to require Tenant to surrender possession of the Premises to Landlord as provided in this Lease upon the expiration or other termination of
this Lease. The provisions of this Article 16 shall not be deemed to limit or constitute a waiver of any other rights or remedies of Landlord provided herein or at law. If Tenant fails to surrender the Premises upon the termination or
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liabilities to Landlord accruing therefrom, Tenant shall protect, defend, indemnify and hold Landlord harmless from all loss, costs (including reasonable attorneys’ fees) and liability
resulting from such failure, including, without limiting the generality of the foregoing, any claims made by any succeeding tenant founded upon such failure to surrender and any lost profits to Landlord resulting therefrom. 

ARTICLE 17  
 ESTOPPEL CERTIFICATES 
 Within ten (10) business days following
a request in writing by Landlord, Tenant shall execute, acknowledge and deliver to Landlord an estoppel certificate, which, as submitted by Landlord, shall be substantially in the form of Exhibit E, attached hereto (or such other
reasonable form as may be required by any prospective mortgagee or purchaser of the Project, or any portion thereof), indicating therein any exceptions thereto that may exist at that time, and shall also contain any other information reasonably
requested by Landlord or Landlord’s mortgagee or prospective mortgagee. Any such certificate may be relied upon by any prospective mortgagee or purchaser of all or any portion of the Project. Tenant shall execute and deliver whatever other
instruments may be reasonably required for such purposes. At any time during the Lease Term, upon delivery of an executed confidentiality agreement reasonably satisfactory to Tenant, which excludes any information which is generally available to the
public, Landlord may require Tenant to provide Landlord with a current financial statement and financial statements of the two (2) years prior to the current financial statement year. Such statements shall be prepared in accordance with
generally accepted accounting principles and, if such is the normal practice of Tenant, shall be audited by an independent certified public accountant. Failure of Tenant to timely execute, acknowledge and deliver such estoppel certificate or other
instruments shall constitute an acceptance of the Premises and an acknowledgment by Tenant that statements included in the estoppel certificate are true and correct, without exception. 

ARTICLE 18 

SUBORDINATION 
 This Lease shall be subject and subordinate to all future ground or underlying leases of the Building or Project and to the lien of any mortgage, trust deed or other encumbrances now or hereafter in force
against the Building or Project or any part thereof, if any, and to all renewals, extensions, modifications, consolidations and replacements thereof, and to all advances made or hereafter to be made upon the security of such mortgages or trust
deeds, unless the holders of such mortgages, trust deeds or other encumbrances, or the lessors under such ground lease or underlying leases, require in writing that this Lease be superior thereto, conditioned upon Landlord and Tenant each executing
a commercially reasonable form of subordination, non-disturbance and attornment agreement. Tenant covenants and agrees in the event any proceedings are brought for the foreclosure of any such mortgage or deed in lieu thereof (or if any ground lease
is terminated), to attorn, without any deductions or set-offs whatsoever (including without limitation, any liability for the previous Landlord’s acts or omissions, any rent prepaid to the previous Landlord more than thirty (30) days in
advance of the due date thereof, or 

  

					
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any modifications to the Lease made without the consent of the Building’s mortgagee or ground lessor (as applicable), to the extent such consent was required under the applicable mortgage or
ground lease), to the lienholder or purchaser or any successors thereto upon any such foreclosure sale or deed in lieu thereof (or to the ground lessor), if so requested to do so by such purchaser or lienholder or ground lessor, and to recognize
such purchaser or lienholder or ground lessor as the lessor under this Lease, provided such lienholder or purchaser or ground lessor shall agree to accept this Lease and not disturb Tenant’s occupancy, so long as Tenant timely pays the rent and
observes and performs the terms, covenants and conditions of this Lease to be observed and performed by Tenant. Landlord’s interest herein may be assigned as security at any time to any lienholder. Conditioned upon Landlord and Tenant each
executing, or having executed, a commercially reasonable form of subordination, non-disturbance and attornment agreement. Tenant shall, within five (5) days of request by Landlord, execute such further instruments or assurances as Landlord may
reasonably deem necessary to evidence or confirm the subordination or superiority of this Lease to any such mortgages, trust deeds, ground leases or underlying leases. Tenant waives the provisions of any current or future statute, rule or law which
may give or purport to give Tenant any right or election to terminate or otherwise adversely affect this Lease and the obligations of the Tenant hereunder in the event of any foreclosure proceeding or sale. 

ARTICLE 19 

DEFAULTS; REMEDIES 
 19.1 Events of Default. The occurrence of any of the following shall constitute an “Event of Default” of this Lease by Tenant (and in each instance Tenant shall be “in
Default”): 
 19.1.1 Any failure by Tenant to pay any Rent or any other charge required to be paid under this Lease, or any
part thereof, when due unless such failure is cured within three (3) days after notice; or 
 19.1.2 Except where a
specific time period is otherwise set forth for Tenant’s performance in this Lease, in which event the failure to perform by Tenant within such time period shall be a default by Tenant under this Section 19.1.2, any failure by Tenant to
observe or perform any other provision, covenant or condition of this Lease to be observed or performed by Tenant where such failure continues for ten (10) days after written notice thereof from Landlord to Tenant; provided that if the nature
of such default is such that the same cannot reasonably be cured within a ten (10) day period, Tenant shall not be deemed to be in default if it diligently commences such cure within such period and thereafter diligently proceeds to rectify and
cure such default, and notifies Landlord in writing each month of the status of the cure and the estimated time when the cure will be completed; or 
 19.1.3 To the extent permitted by law, a general assignment by Tenant or any guarantor of this Lease for the benefit of creditors, or the taking of any corporate action in furtherance of bankruptcy or
dissolution whether or not there exists any proceeding under an insolvency or bankruptcy law, or the filing by or against Tenant or any guarantor of any proceeding under an insolvency or bankruptcy law, unless in the case of a proceeding filed
against Tenant or any guarantor the same is dismissed within sixty (60) days, or the appointment 

  

					
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of a trustee or receiver to take possession of all or substantially all of the assets of Tenant or any guarantor, unless possession is restored to Tenant or such guarantor within thirty
(30) days, or any execution or other judicially authorized seizure of all or substantially all of Tenant’s assets located upon the Premises or of Tenant’s interest in this Lease, unless such seizure is discharged within thirty
(30) days; or 
 19.1.4 Abandonment of all or a substantial portion of the Premises by Tenant; or 

19.1.5 The failure by Tenant to observe or perform according to the provisions of Articles 5, 7, 14, 17, 18 or 21 of this Lease where
such failure continues for more than two (2) business days after notice from Landlord; or 
 19.1.6 An Event of Default
under the terms of that certain Lease between Landlord and Tenant for premises at 790 Lindaro Street, San Rafael, California. 

The notice periods provided herein are in lieu of, and not in addition to, any notice periods provided by law. 

19.2 Remedies Upon Default. Upon the occurrence of any event of default by Tenant, Landlord shall have, in addition to any
other remedies available to Landlord at law or in equity (all of which remedies shall be distinct, separate and cumulative), the option to pursue any one or more of the following remedies, each and all of which shall be cumulative and nonexclusive,
without any notice or demand whatsoever. 
 19.2.1 Terminate this Lease, in which event Tenant shall immediately surrender the
Premises to Landlord, and if Tenant fails to do so, Landlord may, without prejudice to any other remedy which it may have for possession or arrearages in rent, enter upon and take possession of the Premises and expel or remove Tenant and any other
person who may be occupying the Premises or any part thereof, without being liable for prosecution or any claim for damages therefor; and Landlord may recover from Tenant the following: 

(i) The worth at the time of award of unpaid rent which has been earned at the time of such termination; plus 

(ii) The worth at the time of award of the amount by which the unpaid rent which would have been earned after termination until the time
of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
 (iii) The worth
at the time of award of the amount by which the unpaid rent for the balance of the Lease Term after the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(iv) Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its
obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, specifically including but not limited to, brokerage commissions and advertising expenses incurred, expenses of remodeling the Premises or
any portion thereof for a new tenant, whether for the same or a different use, and any special concessions made to obtain a new tenant; and 

  

					
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 (v) At Landlord’s election, such other amounts in addition to or in lieu of the
foregoing as may be permitted from time to time by applicable law. 
 The term “rent” as used in this
Section 19.2 shall be deemed to be and to mean all sums of every nature required to be paid by Tenant pursuant to the terms of this Lease, whether to Landlord or to others. As used in Paragraphs 19.2.1(i) and (ii), above, the “worth at the
time of award” shall be computed by allowing interest at the rate set forth in Article 25 of this Lease, but in no case greater than the maximum amount of such interest permitted by law. As used in Paragraph 19.2.1(iii) above, the
“worth at the time of award” shall be computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent (1%). 

19.2.2 Landlord shall have the remedy described in California Civil Code Section 1951.4 (lessor may continue lease in effect after
lessee’s breach and abandonment and recover rent as it becomes due, if lessee has the right to sublet or assign, subject only to reasonable limitations). Accordingly, if Landlord does not elect to terminate this Lease on account of any default
by Tenant, Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies under this Lease, including the right to recover all rent as it becomes due. 

19.2.3 Landlord shall at all times have the rights and remedies (which shall be cumulative with each other and cumulative and in addition
to those rights and remedies available under Sections 19.2.1 and 19.2.2, above, or any law or other provision of this Lease), without prior demand or notice except as required by applicable law, to seek any declaratory, injunctive or other equitable
relief, and specifically enforce this Lease, or restrain or enjoin a violation or breach of any provision hereof. 
 19.3
Subleases of Tenant. Whether or not Landlord elects to terminate this Lease on account of any default by Tenant, as set forth in this Article 19, Landlord shall have the right to terminate any and all subleases, licenses,
concessions or other consensual arrangements for possession entered into by Tenant and affecting the Premises or may, in Landlord’s sole discretion, succeed to Tenant’s interest in such subleases, licenses, concessions or arrangements. In
the event of Landlord’s election to succeed to Tenant’s interest in any such subleases, licenses, concessions or arrangements, Tenant shall, as of the date of notice by Landlord of such election, have no further right to or interest in the
rent or other consideration receivable thereunder. 
 19.4 Form of Payment After Default. Following the occurrence
of an event of default by Tenant, Landlord shall have the right to require that any or all subsequent amounts paid by Tenant to Landlord hereunder, whether to cure the default in question or otherwise, be paid in the form of cash, money order,
cashier’s or certified check drawn on an institution acceptable to Landlord, or by other means approved by Landlord, notwithstanding any prior practice of accepting payments in any different form. 

  

					
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 19.5 Efforts to Relet. No re-entry or repossession, repairs, maintenance,
changes, alterations and additions, reletting, appointment of a receiver to protect Landlord’s interests hereunder, or any other action or omission by Landlord shall be construed as an election by Landlord to terminate this Lease or
Tenant’s right to possession, or to accept a surrender of the Premises, nor shall same operate to release Tenant in whole or in part from any of Tenant’s obligations hereunder, unless express written notice of such intention is sent by
Landlord to Tenant. Tenant hereby irrevocably waives any right otherwise available under any law to redeem or reinstate this Lease. 
 ARTICLE 20 
 COVENANT OF QUIET ENJOYMENT 

Landlord covenants that Tenant, on paying the Rent, charges for services and other payments herein reserved and on keeping, observing and
performing all the other terms, covenants, conditions, provisions and agreements herein contained on the part of Tenant to be kept, observed and performed, shall, during the Lease Term, peaceably and quietly have, hold and enjoy the Premises subject
to the terms, covenants, conditions, provisions and agreements hereof without interference by any persons lawfully claiming by or through Landlord. The foregoing covenant is in lieu of any other covenant express or implied. 

ARTICLE 21  
 LETTER OF CREDIT 
 21.1 Letter of Credit. Concurrently
with the full execution and delivery of this Lease and that certain Lease to Tenant for premises at 790 Lindaro Street, San Rafael, California (the “790 Lindaro Lease”), Tenant shall deliver to Landlord an unconditional, clean, irrevocable
letter of credit (the “L-C”) in the amount set forth in Section 8 of the Summary (the “L-C Amount”), which L-C shall be in the form required under this Article 21 and shall be issued by Wells Fargo
Bank or other money-center bank (a bank which accepts deposits, maintains accounts, has a local San Francisco Bay Area office which will negotiate a letter of credit, and whose deposits are insured by the FDIC) reasonably acceptable to Landlord (the
“Bank”), with a short term Fitch Rating currency rating which is not less than “F2”, and a long term Fitch Rating currency rating which is not less than “BBB+” (an “Approved Bank”). The L-C shall
be held by Landlord as security for the full and faithful performance by Tenant of all of the provisions of this Lease and the 790 Lindaro Lease. This Lease and the 790 Lindaro Lease each provide that that an Event of Default under either lease is
an Event of Default under the other lease. In no event may an L-C be provided by JPMorgan Chase Bank, Bank One, or any affiliate of either. The L-C shall be in a form and content substantially similar to the L-C as set forth in Exhibit
F, attached hereto. Tenant shall pay all expenses, points and/or fees incurred by Tenant in obtaining the L-C. The L-C shall (i) be “callable” at sight, irrevocable and unconditional, (ii) be maintained in effect, whether
through renewal, substitution, replacement or extension, for the period from the Lease Commencement Date and continuing until the date (the “L-C Expiration Date”) that is one hundred twenty (120) days after the expiration of
the Lease Term (as the same may be extended, and subject to the terms of Section 21.6, below), and Tenant shall deliver a new L-C or certificate of renewal, substitution, replacement or extension to Landlord at least thirty
(30) days 

  

					
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prior to the expiration of the L-C then held by Landlord, without any action whatsoever on the part of Landlord, (iii) be fully assignable by Landlord at Landlord’s expense to its
successors and assigns, (iv) permit partial draws and multiple presentations and drawings, and (v) be otherwise subject to the “International Standby Practices” (ISP 98) International Chamber of Commerce (Publication
No. 590). Landlord, or its then managing agent, shall have the right to draw down an amount up to the face amount of the L-C if any of the following shall have occurred or be applicable: (1) such amount is then due and owing to Landlord
under the terms of this Lease or the 790 Lindaro Lease, Landlord has provided any notice to Tenant required under the terms of this Lease or the 790 Lindaro Lease, and any grace or cure period applicable to the payment of such amount has expired
under this Lease or the 790 Lindaro Lease, or (2) Tenant has filed a voluntary petition under the U. S. Bankruptcy Code or any state bankruptcy code (collectively, “Bankruptcy Code”), or (3) an involuntary petition has
been filed against Tenant under the Bankruptcy Code, or (4) the Bank has notified Landlord that the L-C will not be renewed or extended through the L-C Expiration Date. The L-C will be honored by the Bank regardless of whether Tenant disputes
Landlord’s right to draw upon the L-C. 
 21.2 Maintenance of L-C by Tenant. If, as a result of any drawing
by Landlord on the L-C, the amount of the L-C shall be less than the L-C Amount, Tenant shall, within ten (10) days after receipt of Landlord’s notice that Landlord has drawn upon the L-C, provide Landlord with additional letter(s) of
credit in an amount equal to the deficiency, and any such additional letter(s) of credit shall comply with all of the provisions of this Article 21, and if Tenant fails to comply with the foregoing, the same shall constitute an incurable
Event of Default by Tenant under Section 19.1.3, if not cured within the Section 19.1.3 two (2) business day period following a notice given pursuant to Section 19.1.3. Tenant further covenants and warrants
that it will neither assign nor encumber the L-C or any part thereof and that neither Landlord nor its successors or assigns will be bound by any such assignment, encumbrance, attempted assignment or attempted encumbrance. Without limiting the
generality of the foregoing, if the L-C expires earlier than the L-C Expiration Date, Landlord will accept a renewal, replacement or substitution thereof or therefor (such renewal, replacement or substitution letter of credit to be in effect and
delivered to Landlord, as applicable, not later than thirty (30) days prior to the expiration of the previously existing L-C), and shall be substantially in the form attached hereto as Exhibit F and otherwise comply with the terms
of this Article 21. However, if the L-C is not timely renewed or replaced in accordance with the terms hereof, or if Tenant fails to maintain the L-C in the amount and in accordance with the terms set forth in this Article 21, Landlord
shall have the right to present the L-C to the Bank in accordance with the terms of this Article 21, and the proceeds of the L-C may be applied by Landlord against any unpaid Rent payable by Tenant under this Lease or the 790 Lindaro
Lease and/or to pay for all losses and damages that Landlord has suffered or is awarded at law. Any unused proceeds shall be held as a security deposit and need not be segregated from Landlord’s other assets. Landlord agrees to pay to Tenant
within thirty (30) days after the L-C Expiration Date the amount of any proceeds of the L-C received by Landlord and not applied against any Rent payable by Tenant under this Lease or the 790 Lindaro Lease that was not paid when due or used to
pay for any losses and/or damages suffered by Landlord (or awarded to Landlord at law) as a result of any breach or default by Tenant under this Lease or the 790 Lindaro Lease; provided, however, that if prior to the L-C Expiration Date a voluntary
petition is filed by Tenant, or an involuntary petition is filed against Tenant by any of Tenant’s creditors, under the Bankruptcy Code, then Landlord shall not be obligated to make such payment in the amount of the unused L-C proceeds until
either all preference issues relating to payments under this Lease or the 790 Lindaro Lease have been resolved in such bankruptcy or reorganization case or such bankruptcy or reorganization case has been dismissed. 

  

					
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 21.3 Landlord’s Right to Draw Upon L-C. If an Event of Default, after the
expiration of any applicable notice and cure period, shall have occurred and be continuing under any provision of this Lease or the 790 Lindaro Lease, Landlord may, but without obligation to do so, and without any additional notice to Tenant, draw
upon the L-C, in part or in whole, to cure any such breach or default of Tenant and/or to compensate Landlord for any and all damages of any kind or nature sustained or awarded at law. Landlord shall likewise have the right to draw upon the entire
amount of the L-C in the event Tenant fails to renew the same as required by the terms of Section 21.1, above. The use, application or retention of the L-C, or any portion thereof, by Landlord shall not prevent Landlord from exercising
any other right or remedy provided by this Lease or the 790 Lindaro Lease or by any applicable law, it being intended that Landlord shall not first be required to proceed against the L-C, and shall not operate as a limitation on any recovery to
which Landlord may otherwise be entitled. Tenant agrees not to interfere in any way with payment to Landlord of the proceeds of the L-C, either prior to or following a “draw” by Landlord of any portion of the L-C, regardless of whether any
dispute exists between Tenant and Landlord as to Landlord’s right to draw upon the L-C. No condition or term of this Lease or the 790 Lindaro Lease shall be deemed to render the L-C conditional to justify the issuer of the L-C in failing to
honor a drawing upon such L-C in a timely manner. Tenant agrees and acknowledges that (a) the L-C constitutes a separate and independent contract between Landlord and the Bank, (b) Tenant is not a third party beneficiary of such contract,
(c) Tenant has no property interest whatsoever in the L-C or the proceeds thereof, and (d) in the event Tenant becomes a debtor under any chapter of the Bankruptcy Code, none of Tenant, any trustee, or Tenant’s bankruptcy estate shall
have any right to restrict or limit Landlord’s claim and/or rights to the L-C and/or the proceeds thereof by application of Section 502(b)(6) of the U. S. Bankruptcy Code or otherwise. 

21.4 Transfer of L-C by Landlord. The L-C shall also provide that Landlord, its successors and assigns, may, at any time
and without notice to Tenant and without first obtaining Tenant’s consent thereto, transfer (one or more times) all or any portion of its interest in and to the L-C to another party, person or entity, if and only if such transfer is a part of
the assignment by Landlord of its rights and interests in and to this Lease or the 770 Lindaro Lease, in each case subject to the terms and conditions of this Lease or the 790 Lindaro Lease. In the event of a transfer of Landlord’s interest in
the Building or the building at 790 Lindaro Street, San Rafael, California, Landlord shall transfer the L-C, in whole or in part, to the transferee and thereupon Landlord shall, upon the transferee accepting and assuming Landlord’s obligations
under this Lease or the 790 Lindaro Lease, including this Article 21, without any further agreement between the parties, be released by Tenant from all liability therefor, and it is agreed that the provisions of this Lease or the 790 Lindaro
Lease shall apply to every transfer or assignment of the whole or any portion of said L-C to a new landlord who shall be deemed the Landlord for all purposes under this Lease or the 790 Lindaro Lease. In connection with any such transfer of the L-C
by Landlord, Tenant shall, at Tenant’s sole cost and expense, execute and submit to the Bank such applications, documents and instruments as may be necessary to effectuate such transfer or change in the beneficiary, and Landlord shall be
responsible for paying the Bank’s transfer and processing fees in connection therewith. 

  

					
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 21.5 L-C Not a Security Deposit. Landlord and Tenant acknowledge and agree
that in no event or circumstance shall the L-C or any renewal, substitution or replacement thereof or therefore or any proceeds thereof be (i) deemed to be or treated as a “security deposit” within the meaning of California Civil Code
Section 1950.7, (ii) subject to the terms of such Section 1950.7, or (iii) intended to serve as a “security deposit” within the meaning of such Section 1950.7. The parties hereto (A) recite that the L-C is not
intended to serve as a security deposit and such Section 1950.7 and any and all other laws, rules and regulations applicable to security deposits in the commercial context (“Security Deposit Laws”) shall have no applicability
or relevancy thereto and (B) waive any and all rights, duties and obligations either party may now or, in the future, will have relating to or arising from the Security Deposit Laws. 

21.6 Reduction of L-C Amount. The amount of the letter of credit, which the parties acknowledge shall be in the initial
amount of $4,726,000.00, shall be reduced during the Lease Term as follows: 
  

					
	 Reduction Date
	  	New L-C Amount	 
		
	 January 30, 2013
	  	$	3,545,0000	  
		
	 January 30, 2014
	  	$	2,365,000	  
		
	 January 30, 2015
	  	$	1,180,000	  
		
	 January 30, 2016
	  	$	650,000	  

 The amount of the letter of credit shall additionally be reduced on a proportionate basis in the event of
any permanent recapture of any portion of the Premises by Landlord pursuant to the terms of Section 14.4, above. Notwithstanding anything to the contrary in this Section 21.6, the amount of the letter of credit shall only
decrease as set forth above if, as of the applicable Reduction Date, Tenant is not in default under this Lease and the 790 Lindaro Lease (beyond any applicable notice and cure periods set forth in this Lease and the 790 Lindaro Lease). In the event
Tenant does not satisfy the foregoing condition as of a particular Reduction Date, the L-C shall not be reduced as of such Reduction Date but if Tenant satisfies the L-C Reduction Conditions as of the succeeding Reduction Date, the L-C shall be
decreased to the corresponding “New L-C Amount” set forth above for such succeeding Reduction Date notwithstanding that the prior L-C reduction did not occur (but no reduction prior to such succeeding Reduction Date shall be
permitted). Notwithstanding anything contained herein to the contrary, in no event shall any decrease in the L-C occur pursuant to the terms of this Section 21.6 in the event this Lease or the 790 Lindaro Lease is terminated due to an
Event of Default by Tenant. Not more than thirty (30) days prior to each of the applicable reduction dates, Tenant shall deliver Landlord a Notice (the “Reduction Request”) requesting that Landlord provide the bank issuing the
L-C notice confirming that the applicable reduction is to occur on the reduction date (the “Reduction Certification”). The Reduction Request shall be accompanied by evidence reasonably acceptable to Landlord that Tenant meets the
L-C Reduction Conditions. Within five (5) business days after Landlord’s receipt of the Reduction Request, and provided that Tenant meets the L-C Reduction Conditions, Landlord shall deliver the Reduction Certification to the bank in the
form required by the terms of the L-C. 

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

 ARTICLE 22  

INTENTIONALLY OMITTED 
 ARTICLE 23 
 SIGNS 

23.1 Full Floors. Subject to Landlord’s prior written approval, in its reasonable discretion, and provided all signs
are not visible from the exterior of the Building and are in keeping with the quality of the Project, Tenant, at Tenant’s sole cost and expense, may install identification signage anywhere in the Premises including in the elevator lobby of the
Premises. 
 23.2 Intentionally Omitted. 
 23.3 Prohibited Signage and Other Items. Any signs, notices, logos, pictures, names or advertisements which are installed and that have not been separately approved by Landlord may be
removed without notice by Landlord at the sole expense of Tenant. Except with Landlord’s prior written consent, which may be withheld in Landlord’s sole discretion, Tenant may not install any signs on the exterior or roof of the Project or
the Common Areas. Any signs, window coverings, or blinds (even if the same are located behind the Landlord-approved window coverings for the Building), or other items visible from the exterior of the Premises or Building, shall be subject to the
prior approval of Landlord, in its sole discretion. 
 23.4 Shared Monument Signage. So long as Tenant occupies at
least 25,000 rentable square feet in a specific building, Tenant shall be entitled to shared monument signage at Landlord’s expense. So long as Tenant occupies 25,000 rentable square feet in a specific building, Tenant shall have the right at
Tenant’s expense to install and maintain a single strip of identity signage with non-illuminated individual letters on the exterior of the Building. The specific location of the exterior identity signage shall be subject to Landlord’s
reasonable approval and such signage must be in conformance with the City of San Rafael’s approved SRCC Corporate Center Sign Program and be approved by the City of San Rafael. 

23.5 Removal of Tenant’s Signage. Upon the expiration or earlier termination of the Lease, or upon the
termination of Tenant’s rights to maintain Tenant’s signage on the shared monument sign and/ or the exterior of the building due to Tenant’s failure to meet the minimum occupancy requirements specified in Section 23.4,
Tenant shall, at Tenant’s sole cost and expense, cause the Tenant’s signage to be removed from the shared monument sign and/or the exterior of the Building and shall repair any damage caused by such removal. If Tenant fails to timely
remove such signage or to repair the areas in which such signage was located, as provided in the immediately preceding sentence, then Landlord may perform such work, and all actual costs incurred by Landlord in so performing shall be reimbursed by
Tenant to Landlord within thirty (30) days after Tenant’s receipt of an invoice therefor. The terms and conditions of this Section 23.5 shall survive the expiration or earlier termination of the Lease. 

  

					
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 ARTICLE 24  

COMPLIANCE WITH LAW 
 Tenant shall not do anything or suffer anything to be done in or about the Premises or the Project which will in any way conflict with any law, statute, ordinance or other governmental rule, regulation or
requirement now in force or which may hereafter be enacted or promulgated. At its sole cost and expense, Tenant shall promptly comply with all such governmental measures applicable to its particular use, as opposed to the uses of tenants generally.
Landlord shall be responsible for, and shall pay the cost of (which may be reimbursable as Operating Expenses in accordance with Article 4), compliance with all other such governmental measures. Should any standard or regulation now or hereafter be
imposed on Landlord or Tenant by a state, federal or local governmental body charged with the establishment, regulation and enforcement of occupational, health or safety standards for employers, employees, landlords or tenants, as a result of
Tenant’s particular use, as opposed to the uses of tenants generally, then Tenant agrees, at its sole cost and expense, to comply promptly with such standards or regulations. Tenant shall be responsible, at its sole cost and expense, to make
all alterations to the Premises as are required to comply with the governmental rules, regulations, requirements or standards applicable to its particular use, as opposed to the uses of tenants generally. The judgment of any court of competent
jurisdiction or the admission of Tenant in any judicial action, regardless of whether Landlord is a party thereto, that Tenant has violated any of said governmental measures, shall be conclusive of that fact as between Landlord and Tenant.

 ARTICLE 25 
 LATE CHARGES 
 If any installment of Rent or any other sum due from
Tenant shall not be received by Landlord or Landlord’s designee within five (5) days after said amount is due, then Tenant shall pay to Landlord a late charge equal to five percent (5%) of the overdue amount plus any attorneys’
fees incurred by Landlord by reason of Tenant’s failure to pay Rent and/or other charges when due hereunder. The late charge shall be deemed Additional Rent and the right to require it shall be in addition to all of Landlord’s other rights
and remedies hereunder or at law and shall not be construed as liquidated damages or as limiting Landlord’s remedies in any manner. In addition to the late charge described above, any Rent or other amounts owing hereunder which are not paid
within ten (10) days after the date they are due shall bear interest from the date when due until paid at a rate per annum equal to the lesser of (i) the annual “Bank Prime Loan” rate cited in the Federal Reserve Statistical
Release Publication G.13(415), published on the first Tuesday of each calendar month (or such other comparable index as Landlord and Tenant shall reasonably agree upon if such rate ceases to be published) plus four (4) percentage points, and
(ii) the highest rate permitted by applicable law. 

  

					
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[BIOMARIN PHARMACEUTICAL INC.]

 ARTICLE 26  

LANDLORD’S RIGHT TO CURE DEFAULT; PAYMENTS BY TENANT 

26.1 Landlord’s Cure. All covenants and agreements to be kept or performed by Tenant under this Lease shall be
performed by Tenant at Tenant’s sole cost and expense and without any reduction of Rent, except to the extent, if any, otherwise expressly provided herein. If Tenant shall fail to perform any obligation under this Lease, and such failure shall
continue in excess of the time allowed under Section 19.1.2, above, unless a specific time period is otherwise stated in this Lease, Landlord may, but shall not be obligated to, make any such payment or perform any such act on Tenant’s
part without waiving its rights based upon any default of Tenant and without releasing Tenant from any obligations hereunder. 

26.2 Tenant’s Reimbursement. Except as may be specifically provided to the contrary in this Lease, Tenant shall pay to
Landlord, upon delivery by Landlord to Tenant of statements therefor: (i) sums equal to expenditures reasonably made and obligations reasonably incurred by Landlord in connection with the remedying by Landlord of Tenant’s Defaults pursuant
to the provisions of Section 26.1; (ii) sums equal to all losses, costs, liabilities, damages and expenses referred to in Article 10 of this Lease; and (iii) sums equal to all expenditures made and obligations incurred by
Landlord in collecting or attempting to collect the Rent or in enforcing or attempting to enforce any rights of Landlord under this Lease or pursuant to law, including, without limitation, all legal fees and other amounts so expended. Tenant’s
obligations under this Section 26.2 shall survive the expiration or sooner termination of the Lease Term. 
 ARTICLE 27

 ENTRY BY LANDLORD 
 Provided Landlord use commercially reasonable efforts to minimize interference with Tenant’s use and complies with Tenant’s reasonable requirements that Landlord be accompanied by Tenant’s
representative, Landlord reserves the right at all reasonable times and upon 24 hours prior notice to Tenant (except in the case of an emergency, when no prior notice shall be required) to enter the Premises to (i) inspect them; (ii) show
the Premises to prospective purchasers, mortgagees or during the last 12 months of the Term to tenants, or to current or prospective mortgagees, ground or underlying lessors or insurers; (iii) post notices of nonresponsibility; or (iv) if
permitted or required by the terms of this Lease, alter, improve or repair the Premises or the Building, or for structural alterations, repairs or improvements to the Building or the Building’s systems and equipment. Notwithstanding anything to
the contrary contained in this Article 27, Landlord may enter the Premises at any time to (A) perform services required of Landlord, including janitorial service if requested by and agreed to be paid for by Tenant; (B) take possession
due to any breach of this Lease in the manner provided herein; and (C) perform any covenants of Tenant which Tenant fails to perform. Landlord may make any such entries without the abatement of Rent and may take such reasonable steps as
required to accomplish the stated purposes. Tenant hereby waives any claims for damages or for any injuries or inconvenience to or interference with Tenant’s business, lost profits, any loss of occupancy or quiet enjoyment of the Premises, and
any other loss occasioned thereby. For each of the above purposes, Landlord shall at all times have a key with which to unlock all the doors 

  

					
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in the Premises, excluding Tenant’s vaults, safes and special security areas designated in advance by Tenant. In an emergency, Landlord shall have the right to use any means that Landlord
may deem proper to open the doors in and to the Premises. Any entry into the Premises by Landlord in the manner hereinbefore described shall not be deemed to be a forcible or unlawful entry into, or a detainer of, the Premises, or an actual or
constructive eviction of Tenant from any portion of the Premises. No provision of this Lease shall be construed as obligating Landlord to perform any repairs, alterations or decorations except as otherwise expressly agreed to be performed by
Landlord herein. 
 ARTICLE 28 
 TENANT PARKING 
 28.1 Tenant Parking Passes. Tenant
shall, commencing on the Lease Commencement Date or Beneficial Occupancy, be entitled to the number of parking passes set forth in Section 9 of the Summary, which parking passes shall pertain to the Project parking facility. As of the Lease
Commencement Date, Landlord does not impose a charge for the parking passes. If Tenant requests Landlord to provide Tenant with parking passes in excess of the Parking Pass Ratio set forth in Section 9 of the Summary, then, in consideration of
Landlord’s granting such request, Landlord reserves the right to require Tenant to pay to Landlord for such additional automobile parking passes on a monthly basis the prevailing rate charged from time to time at the location of such parking
passes. In addition, Tenant shall be responsible for the full amount of any taxes imposed by any governmental authority in connection with the renting of such additional parking passes by Tenant or the use of the parking facility by Tenant.
Tenant’s continued right to use the parking passes is conditioned upon Tenant abiding by all rules and regulations which are prescribed from time to time for the orderly operation and use of the parking facility where the parking passes are
located, including any sticker or other identification system established by Landlord, Tenant’s cooperation in seeing that Tenant’s employees and visitors also comply with such rules and regulations and Tenant not being in default under
this Lease 
 28.2 Other Terms. Landlord shall take commercially reasonable steps to insure that use of the
parking areas of the Project are limited to tenants and their employees and invitees. Provided there is no permanent reduction in the number of parking passes allocated to Tenant by this Lease, Landlord specifically reserves the right to change the
size, configuration, design, layout and all other aspects of the Project parking facility at any time and Tenant acknowledges and agrees that Landlord may, without incurring any liability to Tenant and without any abatement of Rent under this Lease,
from time to time, temporarily close-off or restrict access to the Project parking facility for purposes of permitting or facilitating any such construction, alteration or improvements. Landlord may delegate its responsibilities hereunder to a
parking operator in which case such parking operator shall have all the rights of control attributed hereby to the Landlord. The parking passes given to and/or rented by Tenant pursuant to this Article 28 are provided to Tenant solely for use
by Tenant’s own personnel and such passes may not be transferred, assigned, subleased or otherwise alienated by Tenant without Landlord’s prior approval. 

  

					
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 28.3 Parking Procedures. The parking passes initially will not be separately
identified; however Landlord reserves the right in its sole and absolute discretion to separately identify by signs or other markings the area to which Tenant’s parking passes relate. Landlord shall have no obligation to monitor the use of such
parking facility, nor shall Landlord be responsible for any loss or damage to any vehicle or other property or for any injury to any person. Tenant’s parking passes shall be used only for parking of automobiles no larger than full size
passenger automobiles, sport utility vehicles or pick-up trucks. Tenant shall comply with all rules and regulations which may be adopted by Landlord from time to time with respect to parking and/or the parking facilities servicing the Project.
Tenant shall not at any time use more parking passes than the number so allocated to Tenant or park its vehicles or the vehicles of others in any portion of the Project parking facility not designated by Landlord as a non-exclusive parking area.
Tenant shall not have the exclusive right to use any specific parking space unless otherwise permitted by Landlord in writing or in this Lease. If Landlord grants to any other tenant the exclusive right to use any particular parking space(s), Tenant
shall not use such spaces, provided, that Tenant shall not be treated less favorably than other tenants of the Project with respect to parking location assignments, if any. With the exception of Tenant’s visitor parking spaces, as provided in
Section 28.4 below, there are not “assigned parking” spaces in the Project. All trucks (other than pick-up trucks) and delivery vehicles shall be (i) loaded and unloaded in a manner which does not interfere with the businesses of
other occupants of the Project, and (ii) permitted to remain on the Project only so long as is reasonably necessary to complete loading and unloading. In the event Landlord elects in its reasonable discretion or is required by any law to limit
or control parking, whether by validation of parking tickets or any other method of assessment, Tenant agrees to participate in such validation or assessment program under such reasonable rules and regulations as are from time to time established by
Landlord. 
 28.4 Visitor Parking. During the Term Landlord shall provide Tenant at no additional cost with five
(5) designated visitor standard parking spaces of which three (3) will be adjacent to the Building and two (2) will be directly to south of the three (3) aforementioned spaces in the locations shown on the diagram attached hereto
as Exhibit H. Landlord reserves the right to adopt reasonable rules and regulations not inconsistent with the terms of the Leaser, and post appropriate signage limiting the use of such spaces to parking only for Tenant’s visitors.

 ARTICLE 29 
 MISCELLANEOUS PROVISIONS 
 29.1 Terms; Captions. The
words “Landlord” and “Tenant” as used herein shall include the plural as well as the singular. The necessary grammatical changes required to make the provisions hereof apply either to corporations or partnerships or
individuals, men or women, as the case may require, shall in all cases be assumed as though in each case fully expressed. The captions of Articles and Sections are for convenience only and shall not be deemed to limit, construe, affect or alter the
meaning of such Articles and Sections. 
 29.2 Binding Effect. Subject to all other provisions of this Lease, each
of the covenants, conditions and provisions of this Lease shall extend to and shall, as the case may require, bind or inure to the benefit not only of Landlord and of Tenant, but also of their respective heirs, personal representatives, successors
or assigns, provided this clause shall not permit any assignment by Tenant contrary to the provisions of Article 14 of this Lease. 

  

					
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 29.3 No Air Rights. No rights to any view or to light or air over any
property, whether belonging to Landlord or any other person, are granted to Tenant by this Lease. If at any time any windows of the Premises are temporarily darkened or the light or view therefrom is obstructed by reason of any repairs,
improvements, maintenance or cleaning in or about the Project, the same shall be without liability to Landlord and without any reduction or diminution of Tenant’s obligations under this Lease. 

29.4 Modification of Lease. Should any current or prospective mortgagee or ground lessor for the Building or Project
require a modification of this Lease, which modification will not cause an increased cost or expense to Tenant or in any other way materially and adversely change the rights and obligations of Tenant hereunder, then and in such event, Tenant agrees
that this Lease may be so modified and agrees to execute whatever documents are reasonably required therefor and to deliver the same to Landlord within ten (10) days following a request therefor. At the request of Landlord or any mortgagee or
ground lessor, Tenant agrees to execute a short form of Lease and deliver the same to Landlord within ten (10) days following the request therefor. 
 29.5 Transfer of Landlord’s Interest. Tenant acknowledges that Landlord has the right to transfer all or any portion of its interest in the Project or Building and in this Lease, and
Tenant agrees that in the event of any such transfer, and the assumption by the transferee of all of Landlord’s obligations under this Lease, Landlord shall automatically be released from all liability under this Lease and Tenant agrees to look
solely to such transferee for the performance of Landlord’s obligations hereunder after the date of transfer and such transferee shall be deemed to have fully assumed and be liable for all obligations of this Lease to be performed by Landlord,
including the return of any Security Deposit, and Tenant shall attorn to such transferee. Tenant further acknowledges that Landlord may assign its interest in this Lease to a mortgage lender as additional security and agrees that such an assignment
shall not release Landlord from its obligations hereunder and that Tenant shall continue to look to Landlord for the performance of its obligations hereunder. 
 29.6 Prohibition Against Recording. Except as provided in Section 29.4 of this Lease, neither this Lease, nor any memorandum, affidavit or other writing with respect thereto, shall be
recorded by Tenant or by anyone acting through, under or on behalf of Tenant. 
 29.7 Landlord’s Title.
Landlord’s title is and always shall be paramount to the title of Tenant. Nothing herein contained shall empower Tenant to do any act which can, shall or may encumber the title of Landlord. 

29.8 Relationship of Parties. Nothing contained in this Lease shall be deemed or construed by the parties hereto or by any
third party to create the relationship of principal and agent, partnership, joint venturer or any association between Landlord and Tenant. 
 29.9 Application of Payments. Landlord shall have the right to apply payments received from Tenant pursuant to this Lease, regardless of Tenant’s designation of such payments, to
satisfy any obligations of Tenant hereunder, in such order and amounts as Landlord, in its sole discretion, may elect. 

  

					
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 29.10 Time of Essence. Time is of the essence with respect to the performance
of every provision of this Lease in which time of performance is a factor. 
 29.11 Partial Invalidity. If any
term, provision or condition contained in this Lease shall, to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such term, provision or condition to persons or circumstances other than those with respect to
which it is invalid or unenforceable, shall not be affected thereby, and each and every other term, provision and condition of this Lease shall be valid and enforceable to the fullest extent possible permitted by law. 

29.12 No Warranty. In executing and delivering this Lease, Tenant has not relied on any representations, including, but not
limited to, any representation as to the amount of any item comprising Additional Rent or the amount of the Additional Rent in the aggregate or that Landlord is furnishing the same services to other tenants, at all, on the same level or on the same
basis, or any warranty or any statement of Landlord which is not set forth herein or in one or more of the exhibits attached hereto. 
 29.13 Landlord Exculpation. The liability of Landlord or the Landlord Parties to Tenant for any default by Landlord under this Lease or arising in connection herewith or with Landlord’s
operation, management, leasing, repair, renovation, alteration or any other matter relating to the Project or the Premises shall be limited solely and exclusively to an amount which is equal to the lesser of (a) the interest of Landlord in the
Building or (b) the equity interest Landlord would have in the Building if the Building were encumbered by third-party debt in an amount equal to eighty percent (80%) of the value of the Building (as such value is determined by Landlord),
provided that in no event shall such liability extend to any sales or insurance proceeds received by Landlord or the Landlord Parties in connection with the Project, Building or Premises. Neither Landlord, nor any of the Landlord Parties shall have
any personal liability therefor, and Tenant hereby expressly waives and releases such personal liability on behalf of itself and all persons claiming by, through or under Tenant. The limitations of liability contained in this Section 29.13
shall inure to the benefit of Landlord’s and the Landlord Parties’ present and future partners, beneficiaries, officers, directors, trustees, shareholders, agents and employees, and their respective partners, heirs, successors and assigns.
Under no circumstances shall any present or future partner of Landlord (if Landlord is a partnership), or trustee or beneficiary (if Landlord or any partner of Landlord is a trust), have any liability for the performance of Landlord’s
obligations under this Lease. Notwithstanding any contrary provision herein, neither Landlord nor the Landlord Parties shall be liable under any circumstances for injury or damage to, or interference with, Tenant’s business, including but not
limited to, loss of profits, loss of rents or other revenues, loss of business opportunity, loss of goodwill or loss of use, in each case, however occurring. 
 29.14 Entire Agreement. It is understood and acknowledged that there are no oral agreements between the parties hereto affecting this Lease and this Lease constitutes the parties’
entire agreement with respect to the leasing of the Premises and supersedes and cancels any and all previous negotiations, arrangements, brochures, agreements and understandings, if any, 

  

					
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between the parties hereto or displayed by Landlord to Tenant with respect to the subject matter thereof, and none thereof shall be used to interpret or construe this Lease. None of the terms,
covenants, conditions or provisions of this Lease can be modified, deleted or added to except in writing signed by the parties hereto. 
 29.15 Right to Lease. Landlord reserves the absolute right to effect such other tenancies in the Project as Landlord in the exercise of its sole business judgment shall determine to best
promote the interests of the Building or Project. Tenant does not rely on the fact, nor does Landlord represent, that any specific tenant or type or number of tenants shall, during the Lease Term, occupy any space in the Building or Project.
Notwithstanding the preceding provisions of this Section, for so long as Tenant is occupying at least a total of 42,974 square feet in the buildings at 770, 790 and 791 Lindaro Street, San Rafael, California, Landlord shall only lease portions of
the Project for medical uses if those medical uses are located in one (1) building in the Project which Tenant is not occupying. In addition, Landlord shall maintain and operate all space in the Project in a manner consistent with other
first-class, mid-rise office buildings in the central San Rafael, California area which are Comparable Buildings, and ensure that the tenants in the Project are not of a character or reputation or engaged in a business which would be significantly
less prestigious occupants of the Project than Tenant. Landlord agrees that up to 50,000 rentable square feet of space in the Project shall be authorized for R & D lab space for Tenant. 

29.16 Force Majeure. Any prevention, delay or stoppage due to strikes, lockouts, labor disputes, acts of God, inability to
obtain services, labor, or materials or reasonable substitutes therefor, governmental actions, civil commotions, fire or other casualty, and other causes beyond the reasonable control of the party obligated to perform, except with respect to the
obligations imposed with regard to Rent and other charges to be paid by Tenant pursuant to this Lease and except as to Tenant’s obligations under Articles 5 and 24 of this Lease (collectively, a “Force Majeure”),
notwithstanding anything to the contrary contained in this Lease, shall excuse the performance of such party for a period equal to any such prevention, delay or stoppage and, therefore, if this Lease specifies a time period for performance of an
obligation of either party, that time period shall be extended by the period of any delay in such party’s performance caused by a Force Majeure. 
 29.17 Waiver of Redemption by Tenant. Tenant hereby waives, for Tenant and for all those claiming under Tenant, any and all rights now or hereafter existing to redeem by order or judgment of
any court or by any legal process or writ, Tenant’s right of occupancy of the Premises after any termination of this Lease. 
 29.18 Notices. All notices, demands, statements, designations, approvals or other communications (collectively, “Notices”) given or required to be given by either party to
the other hereunder or by law shall be in writing, shall be (A) sent by United States certified or registered mail, postage prepaid, return receipt requested (“Mail”), (B) transmitted by e-mail, if such e-mail is promptly
followed by a Notice sent by Mail, (C) delivered by a nationally recognized overnight courier, or (D) delivered personally. Any Notice shall be sent, transmitted, or delivered, as the case may be, to Tenant at the appropriate address set
forth in Section 10 of the Summary, or to such other place as Tenant may from time to time designate in a Notice to Landlord, or to Landlord at the addresses set forth below, or to such other places as Landlord

  

					
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may from time to time designate in a Notice to Tenant. Any Notice will be deemed given (i) three (3) days after the date it is posted if sent by Mail, (ii) the date the e-mail and
mailed copy is transmitted, (iii) the date the overnight courier delivery is made, or (iv) the date personal delivery is made or attempted to be made. If Tenant is notified of the identity and address of Landlord’s mortgagee or ground
or underlying lessor, Tenant shall give to such mortgagee or ground or underlying lessor written notice of any default by Landlord under the terms of this Lease by registered or certified mail, and such mortgagee or ground or underlying lessor shall
be given a reasonable opportunity to cure such default prior to Tenant’s exercising any remedy available to Tenant. As of the date of this Lease, any Notices to Landlord must be sent, transmitted, or delivered, as the case may be, to the
following addresses: 
 SR Corporate Center Phase Two, LLC 

c/o Seagate Properties, Inc. 
 980 Fifth Avenue 
 San Rafael, California 94901 

Attention: Lease Administrator 
 With a copy to: 
 SR Corporate Center Phase Two, LLC 

c/o J. P. Morgan Investment Management Inc. 
 2029 Century Park East 
 Suite 4150 

Los Angeles, California 90067 
 Attention: Karen M. Wilbrecht 
 With a copy to (which shall not constitute notice):

 Seagate Properties, Inc. 
 750 Lindaro Street, Suite 145 
 San Rafael, CA 94901 

Attention: Lease Administrator 
 29.19 Joint and Several. If there is more than one Tenant, the obligations imposed upon Tenant under this Lease shall be joint and several. 

29.20 Authority. If Tenant is a corporation, trust or partnership, Tenant hereby represents and warrants that Tenant is a
duly formed and existing entity qualified to do business in California and that Tenant has full right and authority to execute and deliver this Lease and that each person signing on behalf of Tenant is authorized to do so. In such event, Tenant
shall, within ten (10) days after execution of this Lease, deliver to Landlord satisfactory evidence of such authority and, if a corporation, upon demand by Landlord, also deliver to Landlord satisfactory evidence of (i) good standing in
Tenant’s state of incorporation and (ii) qualification to do business in California. 
 29.21 Attorneys’
Fees. In the event that either Landlord or Tenant should bring suit for the possession of the Premises, for the recovery of any sum due under this Lease, or because of 

  

					
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the breach of any provision of this Lease or for any other relief against the other, then all costs and expenses, including reasonable attorneys’ fees, incurred by the prevailing party
therein shall be paid by the other party, which obligation on the part of the other party shall be deemed to have accrued on the date of the commencement of such action and shall be enforceable whether or not the action is prosecuted to judgment.

 29.22 Governing Law; WAIVER OF TRIAL BY JURY. This Lease shall be construed and enforced in accordance with the
laws of the State of California. IN ANY ACTION OR PROCEEDING ARISING HEREFROM, LANDLORD AND TENANT HEREBY CONSENT TO (I) THE JURISDICTION OF ANY COMPETENT COURT WITHIN THE STATE OF CALIFORNIA, (II) SERVICE OF PROCESS BY ANY MEANS AUTHORIZED BY
CALIFORNIA LAW, AND (III) IN THE INTEREST OF SAVING TIME AND EXPENSE, TRIAL WITHOUT A JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM BROUGHT BY EITHER OF THE PARTIES HERETO AGAINST THE OTHER OR THEIR SUCCESSORS IN RESPECT OF ANY MATTER ARISING OUT
OF OR IN CONNECTION WITH THIS LEASE, THE RELATIONSHIP OF LANDLORD AND TENANT, TENANT’S USE OR OCCUPANCY OF THE PREMISES, AND/OR ANY CLAIM FOR INJURY OR DAMAGE, OR ANY EMERGENCY OR STATUTORY REMEDY. IN THE EVENT LANDLORD COMMENCES ANY SUMMARY
PROCEEDINGS OR ACTION FOR NONPAYMENT OF BASE RENT OR ADDITIONAL RENT, TENANT SHALL NOT INTERPOSE ANY COUNTERCLAIM OF ANY NATURE OR DESCRIPTION (UNLESS SUCH COUNTERCLAIM SHALL BE MANDATORY) IN ANY SUCH PROCEEDING OR ACTION, BUT SHALL BE RELEGATED TO
AN INDEPENDENT ACTION AT LAW. 
 29.23 Submission of Lease. Submission of this instrument for examination or
signature by Tenant does not constitute a reservation of, option for or option to lease, and it is not effective as a lease or otherwise until execution and delivery by both Landlord and Tenant. 

29.24 Brokers. Landlord and Tenant hereby warrant to each other that they have had no dealings with any real estate broker
or agent in connection with the negotiation of this Lease, excepting only the real estate brokers or agents specified in Section 12 of the Summary (the “Brokers”), and that they know of no other real estate broker or agent who
is entitled to a commission in connection with this Lease. Landlord shall pay the commissions due to Brokers pursuant to a separate agreement between Landlord and Brokers. Each party agrees to indemnify and defend the other party against and hold
the other party harmless from any and all claims, demands, losses, liabilities, lawsuits, judgments, costs and expenses (including without limitation reasonable attorneys’ fees) with respect to any leasing commission or equivalent compensation
alleged to be owing on account of any dealings with any real estate broker or agent, other than the Brokers, occurring by, through, or under the indemnifying party. 
 29.25 Independent Covenants. This Lease shall be construed as though the covenants herein between Landlord and Tenant are independent and not dependent and Tenant hereby expressly waives the
benefit of any statute to the contrary and agrees that if Landlord fails to perform its obligations set forth herein, Tenant shall not be entitled to make any repairs or perform any acts hereunder at Landlord’s expense or to any setoff of the
Rent or other amounts owing hereunder against Landlord. 

  

					
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 29.26 Project or Building Name and Signage. Landlord shall have the right at
any time to change the name of the Project or Building and to install, affix and maintain any and all signs on the exterior and on the interior of the Project or Building as Landlord may, in Landlord’s sole discretion, desire. Tenant shall not
use the name of the Project or Building or use pictures or illustrations of the Project or Building in advertising or other publicity or for any purpose other than as the address of the business to be conducted by Tenant in the Premises, without the
prior written consent of Landlord. 
 29.27 Counterparts. This Lease may be executed in counterparts with the same
effect as if both parties hereto had executed the same document. Both counterparts shall be construed together and shall constitute a single lease. 
 29.28 Confidentiality. Tenant acknowledges that the content of this Lease and any related documents are confidential information. Tenant shall keep such confidential information strictly
confidential and shall not disclose such confidential information to any person or entity other than Tenant’s financial, legal, and space planning consultants. 
 29.29 Transportation Management. Tenant shall fully comply with all present or future programs intended to manage parking, transportation or traffic in and around the Building, and in
connection therewith, Tenant shall take responsible action for the transportation planning and management of all employees located at the Premises by working directly with Landlord, any governmental transportation management organization or any
other transportation-related committees or entities. 
 29.30 Building Renovations. It is specifically understood
and agreed that Landlord has made no representation or warranty to Tenant and has no obligation and has made no promises to alter, remodel, improve, renovate, repair or decorate the Premises, Building, or any part thereof and that no representations
respecting the condition of the Premises or the Building have been made by Landlord to Tenant except as specifically set forth herein or in the Tenant Work Letter. However, Tenant hereby acknowledges that Landlord may during the Lease Term renovate,
improve, alter, or modify (collectively, the “Renovations”) the Project, the Building and/or the Premises including without limitation the parking structure, common areas, systems and equipment, roof, and structural portions of the
same, which Renovations may include, without limitation, (i) modifying the Common Areas and tenant spaces to comply with applicable laws and regulations, including regulations relating to the physically disabled, seismic conditions, and
building safety and security, and (ii) installing new floor covering, lighting, and wall coverings in the Building Common Areas, and in connection with any Renovations, Landlord may, among other things, erect scaffolding or other necessary
structures in the Building, limit or eliminate access to portions of the Project, including portions of the Common Areas, or perform work in the Building, which work may create noise, dust or leave debris in the Building. Tenant hereby agrees that
such Renovations and Landlord’s actions in connection with such Renovations shall in no way constitute a constructive eviction of Tenant nor entitle Tenant to any abatement of Rent. Landlord shall have no responsibility or for any reason be
liable to Tenant for any direct or indirect injury to or interference with Tenant’s business arising from the Renovations, nor shall Tenant be entitled to any compensation or damages from Landlord for loss of the use of the whole or any part of
the Premises or of Tenant’s personal property or improvements resulting from the Renovations or Landlord’s actions in connection with such Renovations, or for any 

  

					
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inconvenience or annoyance occasioned by such Renovations or Landlord’s actions; provided that Landlord shall use commercially reasonable efforts to minimize interference with Tenant’s
use, and shall give Tenant no less than three (3) business days’ prior notice of any planned power interruption. 

29.31 No Violation. Tenant hereby warrants and represents that neither its execution of nor performance under this Lease
shall cause Tenant to be in violation of any agreement, instrument, contract, law, rule or regulation by which Tenant is bound, and Tenant shall protect, defend, indemnify and hold Landlord harmless against any claims, demands, losses, damages,
liabilities, costs and expenses, including, without limitation, reasonable attorneys’ fees and costs, arising from Tenant’s breach of this warranty and representation. 

29.32 Communications and Computer Lines. Tenant may install, maintain, replace, remove or use any communications or
computer wires and cables (collectively, the “Lines”) at the Project in or serving the Premises, provided that (i) Tenant shall obtain Landlord’s prior written consent, use an experienced and qualified contractor approved
in writing by Landlord, and comply with all of the other provisions of Articles 7 and 8 of this Lease, (ii) an acceptable number of spare Lines and space for additional Lines shall be maintained for existing and future occupants of the Project,
as determined in Landlord’s reasonable opinion, (iii) the Lines therefor (including riser cables) shall be appropriately insulated to prevent excessive electromagnetic fields or radiation, and shall be surrounded by a protective conduit
reasonably acceptable to Landlord, and shall be identified in accordance with the “Identification Requirements,” as that term is set forth hereinbelow, (iv) any new or existing Lines servicing the Premises shall comply with all
applicable governmental laws and regulations, (v) as a condition to permitting the installation of new Lines, Landlord may require that Tenant remove existing Lines located in or serving the Premises and repair any damage in connection with
such removal, and (vi) Tenant shall pay all costs in connection therewith. All Lines shall be clearly marked with adhesive plastic labels (or plastic tags attached to such Lines with wire) to show Tenant’s name, suite number, telephone
number and the name of the person to contact in the case of an emergency (A) every four feet (4’) outside the Premises (specifically including, but not limited to, the electrical room risers and other Common Areas), and (B) at
the Lines’ termination point(s) (collectively, the “Identification Requirements”). Upon the expiration of the Lease Term, or immediately following any earlier termination of this Lease, Tenant shall, at Tenant’s sole cost
and expense, remove all Lines installed by Tenant, and repair any damage caused by such removal. In the event that Tenant fails to complete such removal and/or fails to repair any damage caused by the removal of any Lines, Landlord may do so and may
charge the cost thereof to Tenant. In addition, Landlord reserves the right at any time to require that Tenant remove any Lines located in or serving the Premises which are installed in violation of these provisions, or which are at any time in
violation of any laws or represent a dangerous or potentially dangerous condition. 
 29.33 Development of the
Project. 
 29.33.1 Subdivision. Landlord reserves the right to further subdivide all or a portion of the
Project. Tenant agrees to execute and deliver, upon demand by Landlord and in the form requested by Landlord, any additional documents needed to conform this Lease to the circumstances resulting from such subdivision. 

  

					
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 29.33.2 The Other Improvements. If portions of the Project (the “Other
Improvements”) are owned by an entity other than Landlord, Landlord, at its option, may enter into an agreement with the owner or owners of any or all of the Other Improvements to provide (i) for reciprocal rights of access and/or use
of the Project and the Other Improvements, (ii) for the common management, operation, maintenance, improvement and/or repair of all or any portion of the Project and the Other Improvements, (iii) for the allocation of a portion of the
Direct Expenses to the Other Improvements and the operating expenses and taxes for the Other Improvements to the Project, and (iv) for the use or improvement of the Other Improvements and/or the Project in connection with the improvement,
construction, and/or excavation of the Other Improvements and/or the Project. Nothing contained herein shall be deemed or construed to limit or otherwise affect Landlord’s right to convey all or any portion of the Project or any other of
Landlord’s rights described in this Lease. 
 29.33.3 Construction of Project and Other Improvements. Tenant
acknowledges that portions of the Project and/or the Other Improvements may be under construction following Tenant’s occupancy of the Premises, and that such construction may result in levels of noise, dust, obstruction of access, etc. which
are in excess of that present in a fully constructed project. Tenant hereby waives any and all rent offsets or claims of constructive eviction which may arise in connection with such construction. 

29.34 Office and Communications Services. 
 29.34.1 The Provider. Landlord has advised Tenant that certain office and communications services may be offered to tenants of the Building by a concessionaire under contract to Landlord
(“Provider”). Tenant shall be permitted to contract with Provider for the provision of any or all of such services on such terms and conditions as Tenant and Provider may agree. 

29.34.2 Other Terms. Tenant acknowledges and agrees that: (i) Landlord has made no warranty or representation to
Tenant with respect to the availability of any such services, or the quality, reliability or suitability thereof; (ii) the Provider is not acting as the agent or representative of Landlord in the provision of such services, and Landlord shall
have no liability or responsibility for any failure or inadequacy of such services, or any equipment or facilities used in the furnishing thereof, or any act or omission of Provider, or its agents, employees, representatives, officers or
contractors; (iii) Landlord shall have no responsibility or liability for the installation, alteration, repair, maintenance, furnishing, operation, adjustment or removal of any such services, equipment or facilities; and (iv) any contract
or other agreement between Tenant and Provider shall be independent of this Lease, the obligations of Tenant hereunder, and the rights of Landlord hereunder, and, without limiting the foregoing, no default or failure of Provider with respect to any
such services, equipment or facilities, or under any contract or agreement relating thereto, shall have any effect on this Lease or give to Tenant any offset or defense to the full and timely performance of its obligations hereunder, or entitle
Tenant to any abatement of rent or additional rent or any other payment required to be made by Tenant hereunder, or constitute any accrual or constructive eviction of Tenant, or otherwise give rise to any other claim of any nature against Landlord.

  

					
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 29.35 No Discrimination. There shall be no discrimination against, or
segregation of, any person or persons on account of sex, marital status, race, color, religion, creed, national origin or ancestry in the Transfer of the Premises, or any portion thereof, nor shall the Tenant itself, or any person claiming under or
through it, establish or permit any such practice or practices of discrimination or segregation with reference to the selection, location, number, use or occupancy of tenants, lessees, subtenants, sublessees, or vendees of the Premises, or any
portion thereof. 
 29.36 Access Control Cards. Landlord shall have the right to institute access control systems
and/or procedures at the Building and/or Project that may include the provision of personal access control cards to individual employees of Tenant. In such event, any such cards shall be personal to each particular employee, and Tenant shall
cooperate with Landlord in order to ensure that such cards are used by employees of Tenant only, and are not transferred to any other persons. Tenant shall additionally comply with any other reasonable requirements instituted by Landlord in
connection with such systems or procedures. 
 29.37 Wireless Communications. 

29.37.1 Landlord’s Wireless Communication Equipment. Tenant acknowledges that Landlord may elect, in its sole and
absolute discretion, to install and maintain (either itself or through a third party service provider) certain office and communications services (specifically including, without limitation, wireless communication equipment) in the Building or
Project, or any portion thereof (“Landlord’s Communication Equipment”). 
 29.37.2 Tenant’s
Wireless Communication Equipment. Subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed, and subject to, in accordance with, and the terms and conditions set forth in
Article 8, above, and this Section 29.36, Tenant may install and maintain, at Tenant’s sole cost and expense, wireless communication equipment within the Premises (the “Wireless Communication Equipment”).
Such Wireless Communication Equipment shall be used for wireless communications within the Premises only, and shall be for the servicing of the operations conducted by Tenant from within the Premises. Tenant shall not be entitled to license its
Wireless Communication Equipment to any third party, nor shall Tenant be permitted to receive any revenues, fees or any other consideration for the use of such Communication Equipment by any third party. Such Wireless Communication Equipment shall,
in all instances, comply with applicable governmental laws, codes, rules and regulations. 
 29.37.3 Use of Wireless
Equipment. Tenant hereby acknowledges and agrees that its use of the Wireless Communication Equipment (i) shall not be permitted to interfere with any wireless communication equipment or other equipment of any other tenant or occupant
of the Building or Project which was installed and operating in the Project in compliance with laws prior to the time Tenant installed Tenant’s Wireless Tenant’s Communications Equipment, (ii) shall not be permitted to interfere with
any wireless communication equipment or other equipment of any other third-party with whom Landlord has any third-party agreement where such communication equipment was installed and operating in the Project in compliance with laws prior to the time
Tenant installed Tenant’s Wireless Tenant’s Communications Equipment, and (iii) shall not be permitted to interfere with Landlord’s 

  

					
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Communication Equipment which was installed and operating in the Project in compliance with laws prior to the time Tenant installed Tenant’s Wireless Tenant’s Communications Equipment.
Within three (3) days after receipt of notice from Landlord that Tenant is in violation of one or more of the provisions of the preceding sentence, Tenant shall commence steps necessary to eliminate any such interference and diligently
prosecute such efforts to completion, but in no event later than five (5) business days after receipt of Landlord’s notice. If after the date of installation of Tenant’s Wireless Communications Equipment Landlord installs
Landlord’s Communications Equipment in the Project, then upon notice from Tenant to Landlord that Landlord’s Communications Equipment is believed to be interfering with Tenant’s Wireless Communications Equipment, Landlord shall within
a reasonable period of time after receipt of such notice from Tenant eliminate any interference which is caused by Landlord’s Communications Equipment. Tenant hereby acknowledges and agrees that Landlord has made no warranty or representation
to Tenant with respect to the suitability of the Premises for any wireless communications, specifically including, without limitation, with respect to the quality and clarity of any receptions and transmissions to or from the Wireless Communication
Equipment and the presence of any interference with such signals whether emanating from Landlord’s Communication Equipment, the Building, the Project or otherwise. In no event shall any such interfere with Tenant’s Wireless Communication
Equipment have any effect on this Lease or give to Tenant any offset or defense to the full and timely performance of its obligations hereunder, or entitle Tenant to any abatement of rent or additional rent or any other payment required to be made
by Tenant hereunder, or constitute any accrual or constructive eviction of Tenant, or otherwise give rise to any other claim of any nature against Landlord. In no event shall any of the following equipment or systems which are in place in the
Project as of the Lease Commencement Date be deemed to interfere with Tenant’s Wireless Communication Equipment: standard maintenance equipment, mechanical equipment (e.g. HVAC systems), office equipment, computer equipment, telecommunications
systems, and other similar equipment, devices, and systems used in connection with the primary businesses operated at the Project from time to time. 
 ARTICLE 30  
 ROOFTOP ANTENNA 

30.1 Rooftop Antenna Area. 
 30.1.1 Designation. Landlord has designated an area on the roof of the Building as shown on Exhibit “I” attached hereto (the “Rooftop Area”) that
Tenant may use for the purpose of constructing, installing, operating, repairing, replacing (subject to Section 30.3), and maintaining satellite/telecommunications dishes up to two (2) meter(s) in diameter (collectively, the
“Antenna”). 
 30.1.2 Notice of Exercise. Tenant may exercise its right to use the Rooftop Area
upon five (5) business days’ prior written notice delivered to Landlord (the “Notice of Exercise”). The terms of this Article 30 Agreement shall be effective upon the date of this Lease and shall continue in effect
until the expiration or earlier termination of this Article 30 as set forth in Section 30.1.3. 

  

					
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 30.1.3 Use of the Rooftop Area; Term; Exclusive Use. Five
(5) business days following the delivery of the Notice of Exercise, Tenant’s right to use the Rooftop Area to construct, install, operate, repair, replace (subject to Section 30.3) and maintain the Antenna shall commence and
shall continue until the earlier of (i) the expiration or earlier termination of the initial term of the Lease, or (ii) any termination of this Article 30 required by law, governmental authority or quasi-governmental authority. Subject to
the rights of Landlord to maintain and repair the Building in accordance with the terms of this Lease, Tenant shall have the exclusive right to use the Rooftop Area. 
 30.1.4 Access to Antenna. During the term of the rights granted to Tenant under this Article 30 (the “Antenna Term”), Tenant, its agents, employees and contractors,
will have the right of access to the Antenna and the Rooftop Area. 
 30.1.5 Ownership and Removal of
Antenna. The Antenna shall at all times remain the property of Tenant. Tenant shall have the right to remove the Antenna, or any part thereof, at any reasonable time. On or before the expiration or earlier termination of the
Antenna Term, Tenant will remove, at its own cost and expense, the Antenna and all related facilities on the Rooftop Area (specifically including, but not limited to, any fencing and barriers securing the Antenna, and any connections installed by or
on behalf of Tenant), and return the Rooftop Area to its condition existing prior to Tenant’s installation of the Antenna (except for normal wear and tear). If Tenant fails to complete such removal or fails to repair any damage caused by
such removal, Landlord may complete such removal and repair such damage and charge the cost thereof to Tenant, which amounts shall be immediately payable by Tenant. 
 30.1.6 Leaks. Without limiting any other provision of this Lease, Tenant hereby agrees that it shall be solely responsible for, and in accordance with the provisions of
Section 30.5 agrees to indemnify, defend, protect, and hold Landlord and the “Landlord Parties” (as that term is defined in Article 10 of the Lease) harmless from, any leaks which occur in the roof or roof membrane
at or adjacent to the Rooftop Area during the term Antenna Term or, if later, caused by the removal of the Antenna by Tenant. 

30.2 Installation, Maintenance and Operation of Antenna. 

30.2.1 Approvals and Permits. During the Antenna Term and subject to the terms of Section 30.3.2, below,
Tenant may install and operate the Antenna (and install all equipment ancillary to and necessary for the operation of the Antenna) in the Rooftop Area, provided that: (a) Tenant has obtained Landlord’s prior written approval, which
approval shall be in Landlord’s reasonable discretion, of the plans and specifications for the Antenna and all working drawings for the installation of the Antenna, (b) Tenant has obtained all required permits and governmental or
quasi-governmental approvals (including satisfying any applicable Federal Communications Commission and Federal Aviation Administration requirements) to install and operate the Antenna, and (c) Tenant complies with all applicable governmental
and quasi-governmental laws, regulations and building codes in connection with the Rooftop Area and the Antenna. Landlord shall have the right to condition its approval of the Antenna proposed to be installed by Tenant on Tenant, among other
things, erecting fencing or other barriers to secure such device. With regard to Tenant obtaining all required permits and approvals set forth in Section 30.3.1(b) above, Landlord shall reasonably cooperate, at Tenant’s sole
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Tenant; provided, however, that Landlord shall not be responsible for any such approvals. Once Landlord has given its requisite approval, Tenant may not materially alter or modify the
working drawings, or the actual installation of the Antenna without Landlord’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. 

30.2.2 Compatibility with Building Systems and Operations. The Antenna shall be compatible with the Building systems
and equipment and the antennae and other telecommunications devices of Landlord and other tenants located in the Project, and shall not impair window washing or the use of chiller units, the cooling tower, the emergency generator, elevators, machine
rooms, helipads, ventilation shafts, if any, or any other parts of the Building. If the installation, maintenance, repair, operation or removal of the Antenna requires any changes or modifications to any structural systems or components of the
Building or any of the Building’s systems or equipment, Landlord shall have the right to either (i) perform such changes or modifications and Tenant shall pay for the actual costs thereof upon demand or (ii) require Tenant to perform
such changes or modifications at Tenant’s sole cost and expense. If required by Landlord, in its reasonable discretion, or any governmental agency or authority, Tenant shall fully secure the Rooftop Area with suitable fencing or other
required enclosures (including enclosures that shield the visibility of the Rooftop without impairing their operation and maintenance), subject to the terms of Section 30.3.1, above. Landlord shall have the right to post notices of
non-responsibility in connection with any work performed by Tenant or its agents or contractors in connection with this Agreement. The terms and conditions of Articles 8 and 9 of the Lease shall specifically be applicable in connection
with any work performed by Tenant or its agents or contractors in connection with the Antenna or this Article 30. 
 30.3
Use of Rooftop Area. Tenant shall have the right to use the Building electricity located on the roof of the Building for the operation of the Antenna and ancillary equipment installed by Tenant. Tenant will not store any
materials in the Rooftop Area. Tenant will use the Rooftop Area solely for the Antenna and ancillary equipment and to run all necessary cabling and wires to the Antenna (through conduits or in areas designated by Landlord) and not for any other
purpose. Landlord and its agents may enter and inspect the Rooftop Area at any time upon reasonable prior notice to Tenant if accompanied by Tenant’s representative. Concurrently with Tenant’s installation of any locks for the
Rooftop Area, Tenant will deliver to Landlord a key for any such lock. Tenant will not interfere with the mechanical, electrical, heating, ventilation and air conditioning, or plumbing systems of the Building or the operation, reception, or
transmission of any other satellite, microwave, or other broadcasting or receiving devices that are located on the roof of, or in, the Building. 
 30.4 Indemnification and Insurance. Tenant agrees and acknowledges that it shall use the Rooftop Area at its sole risk, and Tenant absolves and fully releases Landlord and Landlord
Parties, from (i) any and all cost, loss, damage, expense, liability, and cause of action, whether foreseeable or not, arising from any cause, that Tenant may suffer to its personal property located in the Rooftop Area, or (ii) that Tenant
or Tenant’s officers, agents, employees, or independent contractors Landlord or the Landlord Parties may suffer as a direct or indirect consequence of Tenant’s use of the Rooftop Area, the Antenna or access areas to the Rooftop Area, or
(iii) any other cost, loss, damage, expense, liability, or cause of action arising from or related to this Article 30, excluding that caused by the negligence or willful misconduct of Landlord or the Landlord Parties or Landlord Event of
Default. In addition, Tenant agrees to 

  

					
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indemnify, defend, protect, and hold Landlord and the Landlord Parties harmless from and against any loss, cost, damage, liability, expense, claim, action or cause of action of any third party
(including, but not limited to, reasonable attorneys’ fees and costs, and, if Landlord requires the removal of the Antenna at the end of the Antenna Term, any leaks in the roof or roof membrane caused by the removal of the Antenna and any other
rooftop equipment), whether foreseeable or not, resulting as a direct or indirect consequence of Tenant’s use of the Rooftop Area, the Antenna or access areas to the Rooftop Area, except when such cost, loss, damage, expense, or liability is
due to the negligence or willful misconduct of Landlord or Landlord Parties or Landlord Event of Default. In addition, Tenant shall cause the Rooftop Area, the Antenna and the obligations assumed by Tenant under this Article 30 to be covered by
the insurance coverage required to be procured by Tenant under the Lease. 
 30.5 Defaults. If Tenant fails
to cure the breach of any of the covenants set forth in this Article 30 within ten (10) business days following written notice from Landlord, Landlord shall have the right to terminate the rights granted to Tenant under this Article 30 upon
written notice to Tenant; provided that if a period longer than ten (10) business days is required to cure, no Event of Default shall be deemed to have occurred if Tenant commences the cure within such period and diligently prosecutes such cure
to completion. In addition, at the option of Landlord, breach of any of the covenants under this Article 30 by Tenant beyond the above-referenced notice and cure period will also constitute an Event of Default by Tenant under the Lease. 

30.6 Notices. Any notice required or permitted to be given under this Article 30 by Tenant or Landlord will be given
under the terms of Section 29.18 of the Lease. 
 30.7 Incorporation of Lease Provisions. All applicable
provisions of the Lease apply to Tenant’s payment of amounts pursuant to this Article 30, and the use of the Rooftop Area in the same manner as those provisions apply to the Premises and are incorporated into this Article 30 by this reference
as though fully set forth in this Article 30. 
 30.8 No Warranty. Landlord has made no warranty or
representation that the Antenna is permitted by law and Tenant assumes all liability and risk in obtaining all permits and approvals necessary for the installation and use of the Antenna. Landlord does not warrant or guaranty that Tenant will
receive unobstructed transmission or reception to or from the Antenna and Tenant assumes the liability for the transmission and reception to and from the Antenna. 
 30.9 Assignment. Notwithstanding any contrary provision set forth in this Article 30, Tenant’s rights contained herein, may not be transferred or assigned to any other person or
entity, and no person or entity other than Tenant and its employees shall be entitled to use the Antenna or the Rooftop Area; provided however, the rights hereunder may be transferred or assigned to an Affiliate of Tenant under Article 14 of
the Lease in conjunction with an assignment of the Lease or a sublease of all of the Premises for all or substantially all of the remainder of the term of the Lease. 

  

					
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 ARTICLE 31 
 EMERGENCY GENERATOR 
 31.1 Emergency Generator. Upon notice
by Tenant to Landlord within sixty (60) days following the Lease Commencement Date, Tenant shall have the right, at Tenant’s sole cost and expense, subject to the terms hereof, to install one (1) approximately
         kw backup emergency power generator unit to provide emergency power to the Premises (the “Generator”) in an area of approximately
         feet by          feet, as set forth on Exhibit J attached to the Lease (the “Emergency Generator Area”). Tenant shall have the
right to terminate its right to use all or a portion the Emergency Area at any time upon not less than thirty (30) days’ notice to Landlord, in which event following such termination, Tenant shall promptly remove Tenant’s Emergency
Generator Equipment pursuant to the terms hereof. The physical appearance and all specifications of the Generator shall be subject to Landlord’s reasonable approval and Landlord may require Tenant to install screening around the Generator, at
Tenant’s sole cost and expense, as reasonably designated by Landlord. Tenant shall be responsible, at Tenant’s sole cost and expense, for (x) obtaining all permits or other governmental approvals required in connection with the
Generator, and (y) repairing and maintaining and causing the Generator to comply with all applicable laws. In no event shall Tenant permit the Generator to interfere with the Building Systems or any other communications equipment at the
Building that is located on or in the Building prior to the installation of the Generator (or reasonable substitutes therefor). In the event Tenant elects to exercise its right to install the Generator, then Tenant shall give Landlord prior notice
thereof and Landlord and Tenant shall execute an amendment to this Lease covering the matters addressed in this Article 31, the installation and maintenance of the Generator and the Generator Fuel Pad described in Section 31.2, Tenant’s
indemnification of Landlord with respect thereto, Tenant’s obligation to remove the Generator (and restore the Emergency Generator Area to its previously existing condition) upon the expiration or earlier termination of this Lease, and other
related matters. Subject to Landlord’s reasonable rules and regulations (including, without limitation, Landlord’s reasonable notice requirements), Tenant shall be permitted to access the Emergency Generator Area in order to install,
repair and maintain the Generator. 
 31.2 Generator Fuel Pad. If Tenant exercises its right to install the Generator
pursuant to Section 31.1, Tenant shall have the right, at Tenant’s sole cost and expense, subject to the terms hereof, to install a fuel tank to service such generator in the area set forth on Exhibit J attached to the Lease (the
“Generator Fuel Pad”). Tenant shall have the right to terminate its right to use all or a portion the Generator Fuel Pad at any time upon not less than thirty (30) days’ notice to Landlord, in which event following such
termination, Tenant, at Tenant’s sole cost, shall promptly remove all of the equipment installed on the Generator Fuel Pad, and repair any damage to the Project resulting from the installation or removal of such equipment. All specifications of
such equipment shall be subject to Landlord’s reasonable approval. Tenant shall be responsible, at Tenant’s sole cost and expense, for (x) obtaining all permits or other governmental approvals required in connection with such
equipment, and (y) repairing and maintaining and causing such equipment to comply with all applicable laws. In the event Tenant elects to exercise its right to install equipment on the Generator Fuel Pad, then Tenant shall give Landlord prior
notice thereof and Landlord and Tenant shall execute an amendment to this Lease covering the matters addressed in this Section 31.2, the payment for installation costs, the installation and maintenance of such equipment, Tenant’s
indemnification of Landlord with 

  

					
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respect thereto, Tenant’s obligation to remove such equipment upon the expiration or earlier termination of this Lease, and other related matters. Subject to Landlord’s reasonable rules
and regulations (including, without limitation, Landlord’s reasonable notice requirements), Tenant shall be permitted to access the Generator Fuel Pad in order to install, repair and maintain Tenant’s equipment thereon. 

[SIGNATURES APPEAR ON NEXT PAGE.] 

  

					
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 IN WITNESS WHEREOF, Landlord and Tenant have caused this Lease to be executed the day and
date first above written. 
  

															
	LANDLORD:	 		 	TENANT:
			
	SR CORPORATE CENTER PHASE TWO, LLC,	 		 	BIOMARIN PHARMACEUTICAL INC.,
	a Delaware limited liability company	 		 	a Delaware corporation
					
	By:	 	 Seagate SR Corporate Center, LLC,
 a California limited liability company
	 		 		 	
						
		 	By:	 	Seagate Second Street, LLC,	 		 	By:	 	 /s/ G. Eric Davis

		 		 	a California limited liability company	 		 	Name:	 	 G. Eric Davis

		 		 		 		 		 	Its:	 	 Sr.VP, General Counsel

		 		 	By:	 	 Seagate Lindaro, LLC,
 a California limited liability company
	 		 		 	
		 		 		 		 		 		 		 	
		 		 		 	By:	 	 /s/ Willis K. Polite Jr.
	 		 		 	
		 		 		 		 	Willis K. Polite Jr.	 		 		 	
		 		 		 	Its:	 	Managing Member	 		 		 	

  

					
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 EXHIBIT A 
 SAN RAFAEL CORPORATE CENTER 
 [DIAGRAMS OF PREMISES] 

  

					
		 	  
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 EXHIBIT A-1 

SAN RAFAEL CORPORATE CENTER 
 [SITE PLAN] 

  

					
		 	  
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 EXHIBIT B 

SAN RAFAEL CORPORATE CENTER 
 TENANT WORK LETTER 
 This Tenant Work Letter shall set forth the terms and
conditions relating to the construction of the tenant improvements in the Premises in the 770 Lindaro Building which shall be referred to herein as the “Premises”. This Tenant Work Letter is essentially organized chronologically and
addresses the issues of the construction of the Premises, in sequence, as such issues will arise during the actual construction of the Premises. All references in this Tenant Work Letter to Articles or Sections of “this Lease” shall mean
the relevant portion of Articles 1 through 29 of the Office Lease to which this Tenant Work Letter is attached as Exhibit B and of which this Tenant Work Letter forms a part, and all references in this Tenant Work Letter
to Sections of “this Tenant Work Letter” shall mean the relevant portion of Sections 1 through 5 of this Tenant Work Letter. 
 SECTION 1 
 DELIVERY OF THE PREMISES 

Tenant acknowledges that Tenant has thoroughly examined the Premises. Upon full execution and delivery of this Lease by Landlord and
Tenant, Landlord shall deliver the Premises and Tenant shall accept the Premises as of January 2, 2012, in the “as-is” condition existing on the date of this Lease. 

SECTION 2 
 TENANT IMPROVEMENTS 
 2.1 Tenant Improvement
Allowance. Tenant shall be entitled to a one-time tenant improvement allowance (the “Tenant Improvement Allowance”) in the amount of $5,007,600 (i.e., $60.00 for each of the square feet of the Premises (83,360 sq.
ft.) for the costs relating to the initial design and construction of Tenant’s improvements, which are permanently affixed to the Premises. Such work, as depicted in the Approved Construction Documents is referred to herein as the
“Tenant Improvements”. In no event shall Landlord be obligated to make disbursements pursuant to this Tenant Work Letter in a total amount which exceeds the Tenant Improvement Allowance and “Landlord’s Drawing
Contribution,” as that term is defined in Section 2.2.2.1 below, unless otherwise expressly set forth in the Lease or this Tenant Work Letter. 
 2.2 Disbursement of the Tenant Improvement Allowance. 
 2.2.1
Tenant Improvement Allowance Items. Except as otherwise set forth in this Tenant Work Letter, the Tenant Improvement Allowance shall be disbursed by Landlord only for the following items and costs (collectively the “Tenant
Improvement Allowance Items”): 

  

					
		 	 EXHIBIT B
 -1-
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[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 2.2.1.1 Payment of the fees of the “Architect/Space Planner” and the
“Engineers,” as those terms are defined in Section 3.1 of this Tenant Work Letter, which payment shall, notwithstanding anything to the contrary contained in this Tenant Work Letter, not exceed an aggregate amount equal to
$5.00 per rentable square foot of the Premises (“Landlord’s Drawing Contribution”), which shall be deducted from the Tenant Improvement Allowance, and payment of the fees incurred by, and the cost of documents and materials
supplied by, Landlord and Landlord’s consultants in connection with the preparation and review of the “Construction Documents,” as that term is defined in Section 3.1 of this Tenant Work Letter; 

2.2.1.2 The payment of plan check, permit and license fees relating to construction of the Tenant Improvements; 

2.2.1.3 The cost of construction of the Tenant Improvements, including, without limitation, demolition, testing and inspection costs,
trash removal costs, parking fees, after-hours utilities usage and contractors’ fees and general conditions; 
 2.2.1.4
The cost of any changes anywhere in the Base Building or the floor of the Building on which the Premises is located, when such changes are required by the Approved Construction Documents or to comply with applicable governmental regulations or
building codes (collectively, the “Code”), such cost to include all direct architectural and/or engineering fees and expenses incurred in connection therewith; 

2.2.1.5 The cost of any changes to the Construction Documents or Tenant Improvements required by Code; 

2.2.1.6 Sales and use taxes and Title 24 fees; 
 2.2.1.7 The “Landlord Coordination Fee,” as that term is defined in Section 4.2.6 of this Tenant Work Letter; and 

2.2.1.8 All other costs approved by or expended by Landlord in connection with the construction of the Tenant Improvements. 

2.2.1.9 Notwithstanding anything to the contrary in this Section 2, all costs for the Landlord Coordination Fee and fees for
Tenant’s Agents (as defined in Section 4.1.2 of this Tenant Work Letter) are to be paid from the Tenant Improvement Allowance. 
 2.2.2 Disbursement of Tenant Improvement Allowance. During the construction of the Tenant Improvements, Landlord shall make monthly disbursements of the Tenant Improvement Allowance for
Tenant Improvement Allowance Items for the benefit of Tenant and shall authorize the release of monies for the benefit of Tenant as follows. 
 2.2.2.1 Monthly Disbursements. On or before the twentieth
(20th) day of each calendar month during the
construction of the Tenant Improvements (the “Submittal Date”) (or such other date as Landlord may designate), Tenant shall deliver to Landlord: (i) a request for payment of the “Contractor,” as that term is defined
in Section 4.1 of this Tenant Work Letter, approved by Tenant showing the schedule, by trade, of percentage of completion of 

  

					
		 	 EXHIBIT B
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[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 
the Tenant Improvements in the Premises; (ii) invoices from all of “Tenant’s Agents,” as that term is defined in Section 4.1.2 of this Tenant Work Letter, for
labor rendered and materials delivered to the Premises (if such invoice is for the Contractor, the Contractor will need to provide an application and certificate for payment [AIA form G702-1992 or equivalent] signed by the Architect/Space Planner,
and a breakdown sheet [AIA form G703-1992 or equivalent]); (iii) an original letter from the Tenant approving such invoices and requesting payment from the Tenant Improvement Allowance; (iv) executed mechanic’s lien releases, which
lien releases shall be conditional with respect to the then-requested payment amounts and unconditional with respect to payment amounts previously disbursed by Landlord or Tenant, from all of Tenant’s Agents which shall comply with the
appropriate provisions, as reasonably determined by Landlord, of California Civil Code Section 3262(d); and (v) all other information reasonably requested by Landlord. Tenant’s request for payment shall be deemed Tenant’s
acceptance and approval of the work furnished and/or the materials supplied as set forth in Tenant’s payment request. On or before the date occurring thirty (30) days after the Submittal Date, and assuming Landlord receives all of the
information described in items (i) through (v), above, Landlord shall deliver a check to Tenant made payable to Tenant’s Agent (or to Tenant if such invoices were previously paid by the Tenant) in payment of the lesser of: (A) the
amounts so requested by Tenant, as set forth in this Section 2.2.2.1, above, up to an aggregate total of ninety percent (90%) of the Tenant Improvement Allowance (the remaining ten percent (10%) of the Tenant Improvement
Allowance shall be the “Final Retention”), and (B) the balance of any remaining available portion of the Tenant Improvement Allowance (not including the Final Retention), provided that Landlord does not dispute any request for
payment based on non-compliance of any work with the “Approved Construction Documents”, as that term is defined in Section 3.4 below, or due to any substandard work, or for any other reason as provided in this Lease.
Landlord’s payment of such amounts shall not be deemed Landlord’s approval or acceptance of the work furnished or materials supplied as set forth in Tenant’s payment request. Notwithstanding anything to the contrary in this
Section 2.2.2.1, any payment by Landlord of the Tenant Improvement Allowance requested by Tenant shall be reduced to account for Tenant’s obligation to pay Tenant’s percentage share of the Over-Allowance Amount in accordance with the
procedure specified in Section 4.3.1 below. 
 2.2.2.2 Final Retention. Subject to the provisions of this
Tenant Work Letter, a check for the Final Retention payable to Tenant shall be delivered by Landlord to Tenant following the completion of construction of the Premises, provided that (i) Tenant delivers to Landlord all of the items outlined in
the “Close-out Requirement” document included in the Construction Rules, Requirements, Specifications, Design Criteria and Building Standards (collectively, the “Final Close-Out Package”), and (ii) Landlord has
determined that no substandard work exists which adversely affects the mechanical, electrical, plumbing, heating, ventilating and air conditioning, life-safety or other systems of the Building, the curtain wall of the Building, the structure or
exterior appearance of the Building, or any other tenant’s use of such other tenant’s leased premises in the Building. 
 2.2.2.3 Other Terms. Landlord shall only be obligated to make disbursements from the Tenant Improvement Allowance to the extent costs are incurred by Tenant for Tenant Improvement Allowance
Items. All Tenant Improvement Allowance Items for which the Tenant Improvement Allowance has been made available shall be deemed Landlord’s property under the terms of Section 8.5 of this Lease. Tenant shall have no claim to any
Tenant Improvement Allowance not expended by Tenant within two (2) years after the Lease Commencement Date and any such sums shall be the sole property of Landlord. 

  

					
		 	 EXHIBIT B
 -3-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 2.3 Construction Rules. Landlord has established construction rules,
regulation, requirements and procedures, and specifications, design criteria and Building standards with which Tenant, the “Architect/Space Planner,” as that term is defined below, and all Tenant’s Agents must comply in designing and
constructing the Tenant Improvements in the Premises in the form attached hereto as Schedule 2 (the “Construction Rules”). 
 SECTION 3 
 CONSTRUCTION DOCUMENTS 

3.1 Selection of Architect/Space Planner/Construction Documents. Tenant shall retain a licensed, competent, reputable
architect/space planner experienced in office space design (the “Architect/Space Planner”) to prepare the Construction Documents. Tenant shall retain one or more of Landlord’s approved engineering consultants listed in the
attached Schedule 1 (the “Engineers”) to prepare all plans and engineering Construction Documents relating to the structural, mechanical, electrical, plumbing, HVAC, lifesafety, and sprinkler work in the Premises. The plans and
drawings to be prepared by Architect/Space Planner and the Engineers hereunder shall be known collectively as the “Construction Documents.” All Construction Documents shall comply with Landlord’s reasonable drawing format and
specifications. Landlord’s review of the Construction Documents as set forth in this Section 3, shall be for its sole purpose and shall not imply Landlord’s review of the same, or obligate Landlord to review the same, for
quality, design, Code compliance or other like matters. Accordingly, notwithstanding that any Construction Documents are reviewed by Landlord or its space planner, architect, engineers and consultants, and notwithstanding any advice or assistance
which may be rendered to Tenant by Landlord or Landlord’s space planner, architect, engineers, and consultants, Landlord shall have no liability whatsoever in connection therewith and shall not be responsible for any omissions or errors
contained in the Construction Documents, and Tenant’s waiver and indemnity set forth in Section 10.1 of this Lease shall specifically apply to the Construction Documents. Furthermore, Tenant and Architect/Space Planner shall verify,
in the field, the dimensions and conditions as shown on the relevant portions of the base building plans, and Tenant and Architect/Space Planner shall be solely responsible for the same, and Landlord shall have no responsibility in connection
therewith. 
 3.2 Final Space Plan. Tenant shall supply Landlord with two (2) copies signed by Tenant of its
final space plan for the Premises before any architectural Construction Documents or engineering drawings have been commenced. The final space plan (the “Final Space Plan”) shall include a layout and designation of all offices,
rooms and other partitioning, their intended use, and equipment to be contained therein. Landlord may request clarification or more specific drawings for special use items not included in the Final Space Plan. Landlord shall advise Tenant within
five (5) business days after Landlord’s receipt of the Final Space Plan for the Premises if the same is satisfactory, incomplete or unsatisfactory because it would result in improvements which are of inferior quality, or are not in
compliance with applicable law or would not be compatible with the Building’s systems. If Tenant is advised that it is unsatisfactory or incomplete in any respect, Tenant shall promptly cause the final Space Plan to

  

					
		 	 EXHIBIT B
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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 
be revised to correct any deficiencies or other matters Landlord may reasonably require. As part of Landlord’s approval of the Final Space Plan, Landlord will attach to the Final Space Plan
a list of “TI Required Removables”, as defined in Section 4.4 of this Tenant Work Letter, with the express understanding that no portion of the lobby shall be included within the definition of TI Required Removables. 

3.3 Final Construction Documents. After the approval of the Final Space Plan by Landlord and Tenant, Tenant shall promptly
cause the Architect/Space Planner and the Engineers to complete the architectural and engineering drawings for the Premises, and Architect/Space Planner shall compile a fully coordinated set of architectural, structural, mechanical, electrical and
plumbing Construction Documents in a form which is complete to allow subcontractors to bid on the work and to obtain all applicable permits (collectively, the “Final Construction Documents”) and shall submit the same to Landlord for
Landlord’s approval. Tenant shall supply Landlord with two (2) copies signed by Tenant of such Final Construction Documents. Landlord shall advise Tenant within ten (10) business days after Landlord’s receipt of the Final
Construction Documents for the Premises if the same is satisfactory, unsatisfactory or incomplete in any respect. If Tenant is advised that the Final Construction Documents are unsatisfactory, incomplete, or unsatisfactory because they are not
consistent with the previously approved Final Space Plan, or would result in improvements which are of inferior quality, or are not in compliance with applicable law or would not be compatible with the Building’s systems, Tenant shall
immediately revise the Final Construction Documents in accordance with such review and any reasonable disapproval of Landlord in connection therewith. 
 3.4 Approved Construction Documents. The Final Construction Documents shall be approved by Landlord (the “Approved Construction Documents”) prior to the commencement of
construction of the Premises by Tenant. After approval by Landlord of the Final Construction Documents Tenant shall cause the Architect/Space Planner to submit the Approved Construction Documents to the appropriate municipal authorities for all
architectural and structural permits (the “Permits”), provided that (a) the Architect/Space Planner shall provide Landlord with a copy of the package that it intends to submit prior to such submission, and (b) if there are
Base Building modifications required to obtain the Permits, then Tenant shall obtain Landlord’s prior written consent to any such Base Building modifications. Tenant hereby agrees that neither Landlord nor Landlord’s consultants shall be
responsible for obtaining any certificate of occupancy (or other documentation or approval allowing Tenant to legally occupy the Premises) for the Premises and that obtaining the same shall be Tenant’s responsibility; provided, however, that
Landlord shall cooperate with Tenant in performing ministerial acts reasonably necessary to enable Tenant to obtain any such certificate of occupancy (or other documentation or approval allowing Tenant to legally occupy the Premises). No changes,
modifications or alterations in the Approved Construction Documents may be made without the prior written consent of Landlord, which consent may not be unreasonably withheld. 

  

					
		 	 EXHIBIT B
 -5-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 SECTION 4 

CONSTRUCTION OF THE TENANT IMPROVEMENTS 
 4.1 Tenant’s Selection of Contractors. 
 4.1.1 The
Contractor. Tenant shall retain a licensed general contractor from one of those listed on the attached Schedule 1 (the “Contractor”), as a contractor for the construction of the Tenant Improvements. 

4.1.2 Tenant’s Agents. The Architect/Space Planner, Engineers, consultants, Contractor, other contractors, vendors,
subcontractors, laborers, materialmen, and suppliers retained and/or used by Tenant shall be known collectively as the “Tenant’s Agents.” The list of Landlord’s Approved Contractors is attached hereto as Schedule 1.
No other contractors may be selected without the written approval of Landlord, which may be withheld by Landlord in its reasonable discretion. 
 4.2 Construction of Tenant Improvements by Tenant’s Agents. 
 4.2.1
Construction Contract; Cost Budget. Prior to commencement of construction, Tenant shall submit a copy of the executed contract with the Contractor for the construction of the Tenant Improvements, including the general conditions
with Contractor (the “Contract”), to Landlord for its records. Prior to the commencement of the construction of the Tenant Improvements, and after Tenant has accepted all bids and proposals for the Tenant Improvements, Tenant shall
provide Landlord with (i) a detailed breakdown, by trade, for all of Tenant’s Agents, of the final estimated costs to be incurred or which have been incurred in connection with the design and construction of the Tenant Improvements to be
performed by or at the direction of Tenant or the Contractor (the “Construction Budget”), which costs shall include, but not be limited to, the costs of the Architect’s and Engineers’ fees and the Landlord Coordination
Fee. The amount, if any, by which the total costs set forth in the Construction Budget exceed the amount of the Tenant Improvement Allowance is referred to herein as the “Over Allowance Amount”. Tenant shall be responsible to pay a
percentage of each disbursement under this Tenant Work Letter, which percentage (the “Over-Allowance Percentage”) shall be equal to the amount of the Over-Allowance Amount, divided by the amount of the Construction Budget, and such
payment by Tenant shall be a condition to Landlord’s obligation to pay any amounts of the Tenant Improvement Allowance. In the event that after the Construction Budget has been delivered by Tenant, the costs relating to the design and
construction of the Tenant Improvements shall be in excess of the estimated amounts as set forth in the Construction Budget and the Over-Allowance Amount, the Over-Allowance Amount shall be re-calculated by Tenant and approved by Landlord and the
respective payments made by Landlord and Tenant as of the date of such re-calculation shall be reconciled and adjusted based on such re-calculation and payment of any difference owed by one party to the to the other based on such reconciliation
shall be made within five (5) business days of the approval of such reconciliation. 

  

					
		 	 EXHIBIT B
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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 4.2.2 Tenant’s Agents. 

4.2.2.1 Landlord’s General Conditions for Tenant’s Agents and Tenant Improvement Work. Tenant’s and
Tenant’s Agent’s construction of the Tenant Improvements shall comply with the following: (i) the Tenant Improvements shall be constructed in strict accordance with the Approved Construction Documents; (ii) Tenant and
Tenant’s Agents shall not, in any way, interfere with, obstruct, or delay, the work of Landlord’s base building contractor and subcontractors with respect to the Base Building or any other work in the Building; (iii) Tenant’s
Agents shall submit schedules of all work relating to the Tenant’s Improvements to Landlord and Landlord shall, within five (5) business days of receipt thereof, inform Tenant’s Agents of any changes which are reasonably necessary
thereto, and Tenant’s Agents shall adhere to such corrected schedule; and (iv) Tenant shall abide by all reasonable rules made by Landlord with respect to the use of parking, freight, loading dock and service elevators, storage of
materials, coordination of work with the contractors of other tenants, and any other matter in connection with this Tenant Work Letter, including, without limitation, the construction of the Tenant Improvements and Tenant shall promptly execute all
documents including, but not limited to, Landlord’s standard contractor’s rules and regulations, as Landlord may deem reasonably necessary to evidence or confirm Tenant’s agreement to so abide. 

4.2.2.2 Indemnity. Tenant’s indemnity of Landlord as set forth in Section 10.1 of this Lease shall also
apply with respect to any and all costs, losses, damages, injuries and liabilities related in any way to any act or omission of Tenant or Tenant’s Agents, or anyone directly or indirectly employed by any of them, or in connection with
Tenant’s non-payment of any amount arising out of the Tenant Improvements and/or Tenant’s disapproval of all or any portion of any request for payment. Such indemnity by Tenant, as set forth in Section 10.1 of this Lease, shall
also apply with respect to any and all costs, losses, damages, injuries and liabilities related in any way to Landlord’s performance of any ministerial acts reasonably necessary (i) to permit Tenant to complete the Tenant Improvements, and
(ii) to enable Tenant to obtain any certificate of occupancy (or other documentation or approval allowing Tenant to legally occupy the Premises) for the Premises. 
 4.2.2.3 Requirements of Tenant’s Agents. Each of Tenant’s Agents shall guarantee to Tenant and for the benefit of Landlord that the portion of the Tenant Improvements for which it
is responsible shall be free from any defects in workmanship and materials for a period of not less than one (1) year from the date of completion thereof. Each of Tenant’s Agents shall be responsible for the replacement or repair, without
additional charge, of all work done or furnished in accordance with its contract that shall become defective within one (1) year after the later to occur of (i) completion of the work performed by such contractor or subcontractors and
(ii) the Lease Commencement Date. The correction of such work shall include, without additional charge, all additional expenses and damages incurred in connection with such removal or replacement of all or any part of the Tenant Improvements,
and/or the Building and/or common areas that may be damaged or disturbed thereby. All such warranties or guarantees as to materials or workmanship of or with respect to the Tenant Improvements shall be contained in the Contract or subcontract and
shall be written such that such guarantees or warranties shall inure to the benefit of both Landlord and Tenant, as their respective interests may appear, and can be directly enforced by either. Tenant covenants to give to Landlord any assignment or
other assurances which may be necessary to effect such right of direct enforcement. 

  

					
		 	 EXHIBIT B
 -7-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 4.2.2.4 Insurance Requirements. 

4.2.2.4.1 General Coverages. All of Tenant’s Agents shall carry worker’s compensation insurance covering all of
their respective employees, and shall also carry commercial general liability insurance, including property damage, all with limits, in form and with companies as are required to be carried by Tenant as set forth in Article 10 of this Lease,
and the policies therefor shall insure Landlord and Tenant, as their interests may appear, as well as the Contractor and subcontractors. 
 4.2.2.4.2 Special Coverages. Tenant or Contractor shall carry “Builder’s All Risk” insurance in an amount approved by Landlord, which shall in no event be less than the amount
actually carried by Tenant or Contractor, covering the construction of the Tenant Improvements, and such other insurance as Landlord may require, it being understood and agreed that the Tenant Improvements shall be insured by Tenant pursuant to
Article 10 of this Lease immediately upon completion thereof. Such insurance shall be in amounts and shall include such extended coverage endorsements as may be reasonably required by Landlord. 

4.2.2.4.3 General Terms. Certificates for all insurance carried pursuant to this Section 4.2.2.4 shall be
delivered to Landlord before the commencement of construction of the Tenant Improvements and before the Contractor’s equipment is moved onto the site. All such policies of insurance must contain a provision that the company writing said policy
will give Landlord thirty (30) days prior written notice of any cancellation or lapse of the effective date or any reduction in the amounts of such insurance. In the event that the Tenant Improvements are damaged by any cause during the course
of the construction thereof, Tenant shall immediately repair the same at Tenant’s sole cost and expense. Tenant’s Agents shall maintain all of the foregoing insurance coverage in force until the Tenant Improvements are fully completed and
accepted by Landlord, except for any Products and Completed Operation Coverage insurance required by Landlord, which is to be maintained for ten (10) years following completion of the work and acceptance by Landlord and Tenant and which shall
name Landlord, and any other party that Landlord so specifies, as additional insured as to the full limits required hereunder for such entire ten (10) year period. All insurance, except Workers’ Compensation, maintained by Tenant’s
Agents shall preclude subrogation claims by the insurer against anyone insured thereunder. Such insurance shall provide that it is primary insurance as respects the owner and that any other insurance maintained by owner is excess and noncontributing
with the insurance required hereunder. The requirements for the foregoing insurance shall not derogate from the provisions for indemnification of Landlord by Tenant under Section 4.2.2.2 of this Tenant Work Letter. 

4.2.3 Governmental Compliance. The Tenant Improvements shall comply in all respects with the following: (i) the Code
and other state, federal, city or quasi-governmental laws, codes, ordinances and regulations, as each may apply according to the rulings of the controlling public official, agent or other person; (ii) applicable standards of the American
Insurance Association (formerly, the National Board of Fire Underwriters) and the National Electrical Code; and (iii) building material manufacturer’s specifications. 

4.2.4 Inspection by Landlord. Landlord shall have the right to inspect the Tenant Improvements at all times, provided
however, that Landlord’s failure to inspect the 

  

					
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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 
Tenant Improvements shall in no event constitute a waiver of any of Landlord’s rights hereunder nor shall Landlord’s inspection of the Tenant Improvements constitute Landlord’s
approval of the same. Should Landlord reasonably disapprove any portion of the Tenant Improvements, because of a defect in materials or workmanship or failure to comply with the Approved Construction Drawings or applicable local, state or federal
building codes or law, Landlord shall notify Tenant in writing of such disapproval and shall specify the items disapproved. Any defects or deviations in, and/or disapproval by Landlord of, the Tenant Improvements shall be rectified by Tenant at no
expense to Landlord, provided however, that in the event Landlord determines that a defect or deviation exists or disapproves any portion of the Tenant Improvements for the reasons set forth above, and Tenant shall have failed to commence correction
within ten (10) business days following Tenant’s receipt of notice of disapproval, Landlord may, take such action as Landlord reasonably deems necessary, at Tenant’s expense and without incurring any liability on Landlord’s part,
to correct any such defect, deviation and/or matter, including, without limitation, causing the cessation of performance of the construction of the Tenant Improvements until such time as the defect, deviation and/or matter is corrected to
Landlord’s satisfaction. 
 4.2.5 Meetings. Commencing upon the execution of this Lease, Tenant shall hold
regular meetings with the Architect/Space Planner and the Contractor regarding the progress of the preparation of Construction Documents and the construction of the Tenant Improvements, which meetings shall be held at the office of the Project, at a
time mutually agreed upon by Landlord and Tenant, and, upon Landlord’s request, certain of Tenant’s Agents shall attend such meetings. In addition, minutes shall be taken at all such meetings, a copy of which minutes shall be promptly
delivered to Landlord. One such meeting each month shall include the review of Contractor’s current request for payment. 

4.2.6 Landlord Coordination Fee. Tenant shall pay a construction supervision and management fee (the “Landlord
Coordination Fee”) to Landlord in an amount equal to the product of (i) two percent (2%) and (ii) the Tenant Improvement Allowance. The Landlord Coordination Fee shall be deducted from the Tenant Improvement Allowance and
shall not exceed $1.20 per foot. 
 4.3 Notice of Completion. Within five (5) days after the final completion
of construction of the Tenant Improvements, including, without limitation, the completion of any punch list items, Tenant shall cause a Notice of Completion to be recorded in the office of the Recorder of the County of Marin in accordance with
Section 3093 of the Civil Code of the State of California or any successor statute, and shall furnish a copy thereof to Landlord upon such recordation. If Tenant fails to do so, Landlord may execute and file the same on behalf of Tenant as
Tenant’s agent for such purpose, at Tenant’s sole cost and expense. 
 4.4 Removal Obligations. In the
event that, in the course of developing the Construction Documents, Tenant changes the configuration of the Premises from that shown in the approved Final Space Plan, Landlord may, by written notice to Tenant given concurrently with giving
Landlord’s consent to the Construction Documents, require Tenant, at Tenant’s expense, to remove at the end of the Term any portion of the Tenant Improvements introduced in the reconfigured plan which in Landlord’s reasonable
judgment, are of a nature that would require removal and repair costs that are materially in excess of the removal and repair costs associated with standard office improvements such as laboratory improvements, any exercise

  

					
		 	 EXHIBIT B
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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 
facility, and any cafeteria (collectively referred to as “TI Required Removables”), and to repair any damage to the Premises and Building caused by such removal. If Tenant fails
to complete such removal and/or to repair any damage caused by the removal of any such TI Required Removables, then at Landlord’s option, either (A) Tenant shall be deemed to be holding over in the Premises and Rent shall continue to
accrue in accordance with the terms of Article 16 of the Lease, until such work shall be completed, or (B) Landlord may do so and may charge the cost thereof to Tenant. Tenant hereby protects, defends, indemnifies and holds Landlord
harmless from any liability, cost, obligation, expense or claim of lien in any manner relating to the installation, placement, and removal or financing of any such Tenant Improvements in, on or about the Premises, which obligations of Tenant shall
survive the expiration or earlier termination of this Lease. In no event shall any portion of the lobby be included within the definition of TI Required Removables. 
 SECTION 5 
 MISCELLANEOUS 

5.1 Tenant’s Representative. Tenant will designate in writing someone as its sole representative with respect to the
matters set forth in this Tenant Work Letter, who shall have full authority and responsibility to act on behalf of the Tenant as required in this Tenant Work Letter, prior to commencing construction of the Tenant Improvements. 

5.2 Landlord’s Representative. Landlord has designated Tom Holman or Willis K. Polite Jr. as its sole representatives
with respect to the matters set forth in this Tenant Work Letter, either of whom, until further notice to Tenant, shall have full authority and responsibility to act on behalf of the Landlord as required in this Tenant Work Letter. 

5.3 Time of the Essence in This Tenant Work Letter. Unless otherwise indicated, all references in this Tenant Work Letter
to a “number of days” shall mean and refer to calendar days. If any item requiring approval is timely disapproved by Landlord, the procedure for preparation of the document and approval thereof shall be repeated until the document is
approved by Landlord. 
 5.4 Tenant’s Lease Default. Notwithstanding any provision to the contrary contained
in this Lease, if an event of Default as described in Section 19.1 of this Lease or a Default by Tenant under this Tenant Work Letter has occurred at any time on or before the substantial completion of the Tenant Improvements in the
Premises, then (i) in addition to all other rights and remedies granted to Landlord pursuant to the Lease, Landlord shall have the right to withhold payment of all or any portion of the Tenant Improvement Allowance and/or Landlord may cause
Contractor to cease the construction of the Premises (in which case, Tenant shall be responsible for any delay in the substantial completion of the Tenant Improvements in the Premises caused by such work stoppage), and (ii) all other
obligations of Landlord under the terms of this Tenant Work Letter shall be forgiven until such time as such Default is cured pursuant to the terms of the Lease (in which case, Tenant shall be responsible for any delay in the substantial completion
of the Tenant Improvements in the Premises caused by such inaction by Landlord). 

  

					
		 	 EXHIBIT B
 -10-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]
 [Tenant-Controlled Build-Out]

 EXHIBIT C 

SAN RAFAEL CORPORATE CENTER 
 NOTICE OF LEASE TERM DATES 
  

							
	To:	  	  
	  		  	
		  	  
	  		  	
		  	  
	  		  	
		  	  
	  		  	

  

	 	Re:	Lease dated                     , 20     between
                    , a                     
(“Landlord”), and                         , a
                         (“Tenant”) concerning Suite          on floor(s)
             of the office building located at
                        ,
                        , California. 

 Gentlemen: 
 In accordance with the Lease (the “Lease”), we wish to
advise you and/or confirm as follows: 
  

	 	1.	The Lease Term shall commence on or has commenced on
                     for a term of
                         ending on
                    . 

  

	 	2.	Rent commenced to accrue on                     , in the amount of
                    . 

  

	 	3.	If the Lease Commencement Date is other than the first day of the month, the first billing will contain a pro rata adjustment. Each billing thereafter, with the
exception of the final billing, shall be for the full amount of the monthly installment as provided for in the Lease. 

  

	 	4.	Your rent checks should be made payable to
                         at
                        . 

  

	 	5.	The exact number of rentable square feet within the Premises is
                     square feet. 

  

					
		 	 EXHIBIT C
  

-1-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

	 	6.	Tenant’s Share of Building Expenses is             %. Tenant’s Share of Project Expenses is
            %. 

  

									
	“Landlord”:	 	
		
	  
	 	,
	a	 	  
	 	

 
									
			
	By:	 	  
	 	
		 	Its:	 	  
	 	

  

							
	Agreed to and Accepted
	as of                     , 20
    .
		
	“Tenant”:	 	
		
	  
	 	,
	a	 	  
	 	

							
			
	By:	 	  
	 	
		 	Its:	 	  
	 	

  

					
		 	 EXHIBIT C
  

-2-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 EXHIBIT D 

SAN RAFAEL CORPORATE CENTER 
 RULES AND REGULATIONS-770 LINDARO 
 Tenant shall faithfully observe and
comply with the following Rules and Regulations. Landlord shall not be responsible to Tenant for the nonperformance of any of said Rules and Regulations by or otherwise with respect to the acts or omissions of any other tenants or occupants of the
Project. In the event of any conflict between the Rules and Regulations and the other provisions of this Lease, the latter shall control. 
 1. Upon the termination of this Lease, Tenant shall return to Landlord all keys of stores, offices, and toilet rooms, either furnished to, or otherwise procured by Tenant. 

2. Intentionally omitted. 
 3. Intentionally omitted. 
 4. Intentionally omitted. 

5. Tenant shall provide protection for all elevator finishes when using same to move furniture, freight, etc. 

6. The requirements of Tenant will be attended to only upon application at the management office for the Project or at such office
location designated by Landlord. Employees of Landlord shall not perform any work or do anything outside their regular duties unless under special instructions from Landlord. 
 7. No sign, advertisement, notice or handbill shall be exhibited, distributed, painted or affixed by Tenant on any part of the exterior of the Building without the prior written consent of the Landlord.
Tenant shall not disturb, solicit, peddle, or canvass any occupant of the Project and shall cooperate with Landlord and its agents of Landlord to prevent same. 
 8. The toilet rooms, urinals, wash bowls and other apparatus shall not be used for any purpose other than that for which they were constructed, and no foreign substance of any kind whatsoever shall be
thrown therein. The expense of any breakage, stoppage or damage resulting from the violation of this rule shall be borne by the tenant who, or whose servants, employees, agents, visitors or licensees shall have caused same. 

9. Tenant shall not overload the floor of the Premises, nor mark, drive nails or screws, or drill into the partitions, woodwork or
drywall or in any way deface the Premises or any part thereof without Landlord’s prior written consent. 
 10. Except for
vending machines intended for the sole use of Tenant’s employees and invitees, no vending machine or machines other than fractional horsepower office machines shall be installed, maintained or operated upon the Premises without the written
consent of Landlord. 

  

					
		 	 EXHIBIT D
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 11. Except as permitted by this Lease, Tenant shall not use or keep in or on the Premises,
the Building, or the Project any kerosene, gasoline, explosive material, corrosive material, material capable of emitting toxic fumes, or other inflammable or combustible fluid chemical, substitute or material. Tenant shall provide material safety
data sheets for any Hazardous Material used or kept on the Premises. 
 12. Intentionally omitted. 

13. Except as permitted by this Lease, Tenant shall not use, keep or permit to be used or kept, any foul or noxious gas or substance in
or on the Premises, or permit or allow the Premises to be occupied or used in a manner offensive or objectionable to Landlord or other occupants of the Project by reason of noise, odors, or vibrations, or interfere with other tenants or those having
business therein, whether by the use of any musical instrument, radio, phonograph, or in any other way. Tenant shall not throw anything out of doors, windows or skylights or down passageways. 

14. Tenant shall not bring into or keep within the Project, the Building or the Premises any animals (other than guide or service dogs),
birds, aquariums, or, except in areas designated by Landlord, bicycles or other vehicles. 
 15. No cooking shall be done or
permitted on the Premises, nor shall the Premises be used for the storage of merchandise, for lodging or for any improper, objectionable or immoral purposes. Notwithstanding the foregoing, Underwriters’ laboratory-approved equipment and
microwave ovens may be used in the Premises for heating food and brewing coffee, tea, hot chocolate and similar beverages for employees and visitors, provided that such use is in accordance with all applicable federal, state, county and city laws,
codes, ordinances, rules and regulations. 
 16. The Premises shall not be used for manufacturing or for the storage of
merchandise except as such storage may be incidental to the use of the Premises provided for in the Summary. Tenant shall not occupy or permit any portion of the Premises to be occupied as an office for a messenger-type operation or dispatch office,
public stenographer or typist, or for the manufacture or sale of liquor, narcotics, or tobacco in any form, or as a medical office, or as a barber or manicure shop, or as an employment bureau without the express prior written consent of Landlord.
Tenant shall not engage or pay any employees on the Premises except those actually working for such tenant on the Premises nor advertise for laborers giving an address at the Premises. 

17. Landlord reserves the right to exclude or expel from the Project any person who, in the judgment of Landlord, is intoxicated or under
the influence of liquor or drugs, or who shall in any manner do any act in violation of any of these Rules and Regulations. 

18. Tenant, its employees and agents shall not loiter in or on the entrances, corridors, sidewalks, lobbies, courts, halls, stairways,
elevators, vestibules or any Common Areas for the purpose of smoking tobacco products or for any other purpose, nor in any way obstruct such areas, and shall use them only as a means of ingress and egress for the Premises. 

  

					
		 	 EXHIBIT D
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 19. Tenant shall not waste electricity, water or air conditioning and agrees to cooperate
fully with Landlord to ensure the most effective operation of the Building’s heating and air conditioning system, and shall refrain from attempting to adjust any controls. Tenant shall participate in recycling programs undertaken by Landlord.

 20. Tenant shall store all its trash and garbage within the interior of the Premises. No material shall be placed in the
trash boxes or receptacles if such material is of such nature that it may not be disposed of in the ordinary and customary manner of removing and disposing of trash and garbage in San Rafael, California without violation of any law or ordinance
governing such disposal. All trash, garbage and refuse disposal shall be made only through entry-ways and elevators provided for such purposes at such times as Landlord shall designate. If the Premises is or becomes infested with vermin as a result
of the use or any misuse or neglect of the Premises by Tenant, its agents, servants, employees, contractors, visitors or licensees, Tenant shall forthwith, at Tenant’s expense, cause the Premises to be exterminated from time to time to the
satisfaction of Landlord and shall employ such licensed exterminators as shall be approved in writing in advance by Landlord. 

21. Tenant shall comply with all safety, fire protection and evacuation procedures and regulations established by Landlord or any
governmental agency. 
 22. Any persons employed by Tenant to do janitorial work shall be subject to the prior written approval
of Landlord and Tenant shall be responsible for all acts of such persons. 
 23. No awnings or other projection shall be
attached to the outside walls of the Building without the prior written consent of Landlord, and no curtains, blinds, shades or screens shall be attached to or hung in, or used in connection with, any window or door of the Premises other than
Landlord standard window coverings. Neither the interior nor exterior of any windows shall be coated or otherwise sunscreened without the prior written consent of Landlord. 
 24. Intentionally omitted. 
 25. Tenant must comply with requests by the Landlord
concerning the informing of their employees of items of importance to the Landlord. 
 26. Tenant must comply with all
applicable “NO-SMOKING” or similar ordinances. If Tenant is required under the ordinance to adopt a written smoking policy, a copy of said policy shall be on file in the office of the Building. 

27. Tenant hereby acknowledges that Landlord shall have no obligation to provide guard service or other security measures for the benefit
of the Premises, the Building or the Project. Tenant hereby assumes all responsibility for the protection of Tenant and its agents, employees, contractors, invitees and guests, and the property thereof, from acts of third parties, including keeping
doors locked and other means of entry to the Premises closed, whether or not Landlord, at its option, elects to provide security protection for the Project or any portion thereof. Tenant further assumes the risk that any safety and security devices,
services and programs which Landlord elects, in its sole discretion, to provide may not be effective, or may malfunction or be circumvented by an unauthorized third party, and Tenant shall, in addition to its other

  

					
		 	 EXHIBIT D
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 
insurance obligations under this Lease, obtain its own insurance coverage to the extent Tenant desires protection against losses related to such occurrences. Tenant shall cooperate in any
reasonable safety or security program developed by Landlord or required by law. 
 28. Intentionally omitted. 

29. Intentionally omitted. 
 30. No auction, liquidation, fire sale, going-out-of-business or bankruptcy sale shall be conducted in the Premises without the prior written consent of Landlord. 

31. No tenant shall use or permit the use of any portion of the Premises for living quarters, sleeping apartments or lodging rooms.

 32. Intentionally omitted. 
 33. Tenant shall install and maintain, at Tenant’s sole cost and expense, an adequate, visibly marked and properly operational fire extinguisher next to any duplicating or photocopying machines or
similar heat producing equipment, which may or may not contain combustible material, in the Premises. 
 Landlord reserves the
right at any time to change or rescind any one or more of these Rules and Regulations, or to make such other and further reasonable Rules and Regulations not inconsistent with the terms of the Lease as in Landlord’s judgment may from time to
time be necessary for the management, safety, care and cleanliness of the Premises, Building, the Common Areas and the Project, and for the preservation of good order therein, as well as for the convenience of other occupants and tenants therein.
Landlord may waive any one or more of these Rules and Regulations for the benefit of any particular tenants, but no such waiver by Landlord shall be construed as a waiver of such Rules and Regulations in favor of any other tenant, nor prevent
Landlord from thereafter enforcing any such Rules or Regulations against any or all tenants of the Project. Tenant shall be deemed to have read these Rules and Regulations and to have agreed to abide by them as a condition of its occupancy of the
Premises. 

  

					
		 	 EXHIBIT D
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 EXHIBIT E 

SAN RAFAEL CORPORATE CENTER 
 FORM OF TENANT ESTOPPEL CERTIFICATE 
 The undersigned as Tenant
under that certain Lease (the “Lease”) made and entered into as of                     , 20     by and between
                     as Landlord, and the undersigned as Tenant, for Premises on the
                     floor(s) of the office building located at
                    ,
                        , California
                    , certifies as follows: 
 1. Attached hereto as Exhibit A is a true and correct copy of the Lease and all amendments and modifications thereto. The documents contained in Exhibit A represent the entire agreement between the
parties as to the Premises. 
 2. The undersigned currently occupies the Premises described in the Lease, the Lease Term
commenced on             , and the Lease Term expires on             , and the undersigned has no option to terminate or cancel
the Lease or to purchase all or any part of the Premises, the Building and/or the Project. 
 3. Base Rent became payable on
            . 
 4. The Lease is in full force and effect and has
not been modified, supplemented or amended in any way except as provided in Exhibit A. 
 5. Tenant has not transferred,
assigned, or sublet any portion of the Premises nor entered into any license or concession agreements with respect thereto except as follows: 
 6. Tenant shall not modify the documents contained in Exhibit A without the prior written consent of Landlord’s mortgagee. 
 7. All monthly installments of Base Rent, all Additional Rent and all monthly installments of estimated Additional Rent have been paid when due through
            . The current monthly installment of Base Rent is $                    .

 8. All conditions of the Lease to be performed by Landlord necessary to the enforceability of the Lease have been satisfied
and Landlord is not in default thereunder. In addition, the undersigned has not delivered any notice to Landlord regarding a default by Landlord thereunder. 
 9. No rental has been paid more than thirty (30) days in advance and no security has been deposited with Landlord except as provided in the Lease. 

  

					
		 	 EXHIBIT E
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 10. As of the date hereof, there are no existing defenses or offsets, or, to the
undersigned’s knowledge, claims or any basis for a claim, that the undersigned has against Landlord. 
 11. If Tenant is a
corporation or partnership, Tenant hereby represents and warrants that Tenant is a duly formed and existing entity qualified to do business in California and that Tenant has full right and authority to execute and deliver this Estoppel Certificate
and that each person signing on behalf of Tenant is authorized to do so. 
 12. There are no actions pending against the
undersigned under the bankruptcy or similar laws of the United States or any state. 
 13. Other than in compliance with all
applicable laws and the Lease, the undersigned has not used or stored any hazardous substances in the Premises. 
 14. To the
undersigned’s knowledge, all tenant improvement work to be performed by Landlord under the Lease has been completed in accordance with the Lease and has been accepted by the undersigned and all reimbursements and allowances due to the
undersigned under the Lease in connection with any tenant improvement work have been paid in full. 
 The undersigned
acknowledges that this Estoppel Certificate may be delivered to Landlord or to a prospective mortgagee or prospective purchaser, and acknowledges that said prospective mortgagee or prospective purchaser will be relying upon the statements contained
herein in making the loan or acquiring the property of which the Premises are a part and that receipt by it of this certificate is a condition of making such loan or acquiring such property. 

Executed at                      on
the      day of                     , 20    . 

 

							
	“Tenant”:	 	
		
	  
	 	,
	a	 	  
	 	
			
	By:	 	  
	 	
		 	Its:	 	  
	 	
			
	By:	 	  
	 	
		 	Its:	 	  
	 	

  

					
		 	 EXHIBIT E
  

-2-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 EXHIBIT F 

SAN RAFAEL CORPORATE CENTER 
 FORM OF LETTER OF CREDIT 
 (Letterhead of a money center bank

 acceptable to the Landlord) 
  

			
	 FAX NO. [(    )
        -        ]
 SWIFT: [Insert No., if
any]
	  	[Insert Bank Name And Address]
		
		  	DATE OF ISSUE:                 
		
	 BENEFICIARY:
 [Insert
Beneficiary Name And Address]
	  	 APPLICANT:
 [Insert
Applicant Name And Address]

		
		  	LETTER OF CREDIT NO. 
		
	 EXPIRATION DATE: 

             AT OUR COUNTERS
	  	 AMOUNT AVAILABLE:

USD[Insert Dollar Amount]
 (U.S. DOLLARS [Insert
Dollar Amount])

 LADIES AND GENTLEMEN: 
 WE HEREBY ESTABLISH OUR IRREVOCABLE STANDBY LETTER OF CREDIT NO.              IN YOUR FAVOR FOR THE ACCOUNT OF BIOMARIN PHARMACEUTICAL INC., A
DELAWARE CORPORATION UP TO THE AGGREGATE AMOUNT OF USD FOUR MILLION SEVEN HUNDRED TWENTY-SIX THOUSAND (4,726,000 U.S. DOLLARS) EFFECTIVE IMMEDIATELY AND EXPIRING ON (Expiration Date) AVAILABLE BY PAYMENT UPON PRESENTATION OF YOUR DRAFT AT
SIGHT DRAWN ON [Insert Bank Name] WHEN ACCOMPANIED BY THE FOLLOWING DOCUMENT(S): 
 1. THE ORIGINAL OF THIS IRREVOCABLE
STANDBY LETTER OF CREDIT AND AMENDMENT(S), IF ANY. 
 2. BENEFICIARY’S SIGNED STATEMENT PURPORTEDLY SIGNED BY
AN AUTHORIZED REPRESENTATIVE OF [Insert Landlord’s Name], A [Insert Entity Type] (“LANDLORD”) STATING THE FOLLOWING: 
 “THE UNDERSIGNED HEREBY CERTIFIES THAT THE LANDLORD, EITHER (A) UNDER THE LEASES (DEFINED BELOW), OR (B) AS A RESULT OF THE TERMINATION OF SUCH LEASES, HAS THE RIGHT TO DRAW DOWN THE
AMOUNT OF USD              IN ACCORDANCE WITH THE TERMS OF THOSE CERTAIN LEASES DATED [Insert Leases 

  

					
		 	 EXHIBIT F
  

-1-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 
Dates], (COLLECTIVELY, THE “LEASES”), OR SUCH AMOUNT CONSTITUTES DAMAGES OWING BY THE TENANT UNDER SUCH LEASES TO BENEFICIARY RESULTING FROM THE BREACH OF SUCH LEASES BY THE TENANT
THEREUNDER, AND SUCH AMOUNT REMAINS UNPAID AT THE TIME OF THIS DRAWING.” 
 OR 

“THE UNDERSIGNED HEREBY CERTIFIES THAT WE HAVE RECEIVED A WRITTEN NOTICE OF [Insert Bank Name]’S ELECTION NOT TO EXTEND ITS
STANDBY LETTER OF CREDIT NO.                      AND HAVE NOT RECEIVED A REPLACEMENT LETTER OF CREDIT WITHIN AT LEAST SIXTY (60) DAYS PRIOR TO
THE PRESENT EXPIRATION DATE.” 
 OR 
 “THE UNDERSIGNED HEREBY CERTIFIES THAT BENEFICIARY IS ENTITLED TO DRAW DOWN THE FULL AMOUNT OF LETTER OF CREDIT NO.              AS THE
RESULT OF THE FILING OF A VOLUNTARY PETITION UNDER THE U.S. BANKRUPTCY CODE OR A STATE BANKRUPTCY CODE BY THE TENANT UNDER THOSE CERTAIN LEASES DATED DECEMBER     , 2011 (COLLECTIVELY, THE “LEASES”), WHICH FILING HAS
NOT BEEN DISMISSED AT THE TIME OF THIS DRAWING.” 
 OR 
 “THE UNDERSIGNED HEREBY CERTIFIES THAT BENEFICIARY IS ENTITLED TO DRAW DOWN THE FULL AMOUNT OF LETTER OF CREDIT NO.              AS THE
RESULT OF AN INVOLUNTARY PETITION HAVING BEEN FILED UNDER THE U.S. BANKRUPTCY CODE OR A STATE BANKRUPTCY CODE AGAINST THE TENANT UNDER THOSE CERTAIN LEASES DATED DECEMBER     , 2011 (COLLECTIVELY, THE “LEASES”), WHICH
FILING HAS NOT BEEN DISMISSED AT THE TIME OF THIS DRAWING.” 
 SPECIAL CONDITIONS: 

PARTIAL DRAWINGS AND MULTIPLE PRESENTATIONS MAY BE MADE UNDER THIS STANDBY LETTER OF CREDIT, PROVIDED, HOWEVER, THAT EACH SUCH DEMAND THAT IS PAID BY US
SHALL REDUCE THE AMOUNT AVAILABLE UNDER THIS STANDBY LETTER OF CREDIT. 
 ALL INFORMATION REQUIRED WHETHER INDICATED BY BLANKS, BRACKETS OR
OTHERWISE, MUST BE COMPLETED AT THE TIME OF DRAWING. [Please Provide The Required Forms For Review, And Attach As Schedules To The Letter Of Credit.] 

  

					
		 	 EXHIBIT F
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 ALL SIGNATURES MUST BE MANUALLY EXECUTED IN ORIGINALS. 

ALL BANKING CHARGES ARE FOR THE APPLICANT’S ACCOUNT. 
 IT IS A CONDITION OF THIS STANDBY LETTER OF CREDIT THAT IT SHALL BE DEEMED AUTOMATICALLY EXTENDED WITHOUT AMENDMENT FOR A PERIOD OF ONE YEAR FROM THE PRESENT OR ANY FUTURE EXPIRATION DATE, UNLESS AT
LEAST SIXTY (60) DAYS PRIOR TO THE EXPIRATION DATE WE SEND YOU NOTICE BY NATIONALLY RECOGNIZED OVERNIGHT COURIER SERVICE THAT WE ELECT NOT TO EXTEND THIS CREDIT FOR ANY SUCH ADDITIONAL PERIOD. SAID NOTICE WILL BE SENT TO THE ADDRESS
INDICATED ABOVE, UNLESS A CHANGE OF ADDRESS IS OTHERWISE NOTIFIED BY YOU TO US IN WRITING BY RECEIPTED MAIL OR COURIER. ANY NOTICE TO US WILL BE DEEMED EFFECTIVE ONLY UPON ACTUAL RECEIPT BY US AT OUR DESIGNATED OFFICE. IN NO EVENT, AND WITHOUT
FURTHER NOTICE FROM OURSELVES, SHALL THE EXPIRATION DATE BE EXTENDED BEYOND A FINAL EXPIRATION DATE OF JUNE 30, 2022 (Expiration Date). 

THIS LETTER OF CREDIT MAY BE TRANSFERRED SUCCESSIVELY IN WHOLE OR IN PART ONLY UP TO THE THEN AVAILABLE AMOUNT IN FAVOR OF A NOMINATED TRANSFEREE
(“TRANSFEREE”), ASSUMING SUCH TRANSFER TO SUCH TRANSFEREE IS IN COMPLIANCE WITH ALL APPLICABLE U.S. LAWS AND REGULATIONS. AT THE TIME OF TRANSFER, THE ORIGINAL LETTER OF CREDIT AND ORIGINAL AMENDMENT(S) IF ANY, MUST BE SURRENDERED TO
US TOGETHER WITH OUR TRANSFER FORM (AVAILABLE UPON REQUEST) AND PAYMENT OF OUR CUSTOMARY TRANSFER FEES BY APPLICANT. IN CASE OF ANY TRANSFER UNDER THIS LETTER OF CREDIT, THE DRAFT AND ANY REQUIRED STATEMENT MUST BE EXECUTED BY THE TRANSFEREE
AND WHERE THE BENEFICIARY’S NAME APPEARS WITHIN THIS STANDBY LETTER OF CREDIT, THE TRANSFEREE’S NAME IS AUTOMATICALLY SUBSTITUTED THEREFOR. 
 ALL DRAFTS REQUIRED UNDER THIS STANDBY LETTER OF CREDIT MUST BE MARKED: “DRAWN UNDER [Insert Bank Name] STANDBY LETTER OF CREDIT NO.
            .” 
 WE HEREBY AGREE WITH YOU THAT IF DRAFTS ARE PRESENTED TO
[Insert Bank Name] UNDER THIS LETTER OF CREDIT AT OR PRIOR TO [Insert Time – (e.g., 11:00 AM)], ON A BUSINESS DAY, AND PROVIDED THAT SUCH DRAFTS PRESENTED CONFORM TO THE TERMS AND CONDITIONS OF THIS LETTER OF CREDIT, PAYMENT SHALL BE
INITIATED BY US IN IMMEDIATELY AVAILABLE FUNDS BY OUR CLOSE OF BUSINESS ON THE SUCCEEDING BUSINESS DAY. IF DRAFTS ARE PRESENTED TO [Insert Bank Name] UNDER THIS LETTER OF CREDIT AFTER [Insert Time – (e.g., 11:00 AM)], ON A BUSINESS
DAY, AND PROVIDED THAT SUCH DRAFTS CONFORM WITH THE TERMS AND CONDITIONS OF THIS LETTER OF CREDIT, PAYMENT SHALL BE INITIATED BY US IN IMMEDIATELY AVAILABLE FUNDS BY OUR CLOSE OF BUSINESS ON THE SECOND SUCCEEDING BUSINESS DAY. AS USED IN THIS
LETTER OF CREDIT, “BUSINESS DAY” SHALL MEAN ANY DAY 

  

					
		 	 EXHIBIT F
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 
OTHER THAN A SATURDAY, SUNDAY OR A DAY ON WHICH BANKING INSTITUTIONS IN THE STATE OF CALIFORNIA ARE AUTHORIZED OR REQUIRED BY LAW TO CLOSE. IF THE EXPIRATION DATE FOR THIS LETTER OF CREDIT
SHALL EVER FALL ON A DAY WHICH IS NOT A BUSINESS DAY THEN SUCH EXPIRATION DATE SHALL AUTOMATICALLY BE EXTENDED TO THE DATE WHICH IS THE NEXT BUSINESS DAY. 
 PRESENTATION OF A DRAWING UNDER THIS LETTER OF CREDIT MAY BE MADE ON OR PRIOR TO THE THEN CURRENT EXPIRATION DATE HEREOF BY HAND DELIVERY, COURIER SERVICE, OVERNIGHT MAIL, OR FACSIMILE. PRESENTATION
BY FACSIMILE TRANSMISSION SHALL BE BY TRANSMISSION OF THE ABOVE REQUIRED SIGHT DRAFT DRAWN ON US TOGETHER WITH THIS LETTER OF CREDIT TO OUR FACSIMILE NUMBER, [Insert Fax Number – (    )
    -        ], ATTENTION: [Insert Appropriate Recipient], WITH TELEPHONIC CONFIRMATION OF OUR RECEIPT OF SUCH FACSIMILE TRANSMISSION AT OUR TELEPHONE NUMBER [Insert Telephone Number
– (    )         -        ] OR TO SUCH OTHER FACSIMILE OR TELEPHONE NUMBERS, AS TO WHICH YOU HAVE RECEIVED WRITTEN NOTICE FROM US AS BEING THE
APPLICABLE SUCH NUMBER. WE AGREE TO NOTIFY YOU IN WRITING, BY NATIONALLY RECOGNIZED OVERNIGHT COURIER SERVICE, OF ANY CHANGE IN SUCH DIRECTION. ANY FACSIMILE PRESENTATION PURSUANT TO THIS PARAGRAPH SHALL ALSO STATE THEREON THAT THE
ORIGINAL OF SUCH SIGHT DRAFT AND LETTER OF CREDIT ARE BEING REMITTED, FOR DELIVERY ON THE NEXT BUSINESS DAY, TO [Insert Bank Name] AT THE APPLICABLE ADDRESS FOR PRESENTMENT PURSUANT TO THE PARAGRAPH FOLLOWING THIS ONE. 

WE HEREBY ENGAGE WITH YOU THAT ALL DOCUMENT(S) DRAWN UNDER AND IN COMPLIANCE WITH THE TERMS OF THIS STANDBY LETTER OF CREDIT WILL BE DULY HONORED IF
DRAWN AND PRESENTED FOR PAYMENT AT OUR OFFICE LOCATED AT [Insert Bank Name], [Insert Bank Address], ATTN: [Insert Appropriate Recipient], ON OR BEFORE THE EXPIRATION DATE OF THIS CREDIT, (Expiration Date). 

IN THE EVENT THAT THE ORIGINAL OF THIS STANDBY LETTER OF CREDIT IS LOST, STOLEN, MUTILATED, OR OTHERWISE DESTROYED, WE HEREBY AGREE TO ISSUE A DUPLICATE
ORIGINAL HEREOF UPON RECEIPT OF A WRITTEN REQUEST FROM YOU AND A CERTIFICATION BY YOU (PURPORTEDLY SIGNED BY YOUR AUTHORIZED REPRESENTATIVE) OF THE LOSS, THEFT, MUTILATION, OR OTHER DESTRUCTION OF THE ORIGINAL HEREOF. 

EXCEPT SO FAR AS OTHERWISE EXPRESSLY STATED HEREIN, THIS STANDBY LETTER OF CREDIT IS SUBJECT TO THE “INTERNATIONAL STANDBY PRACTICES” (ISP 98)
INTERNATIONAL CHAMBER OF COMMERCE (PUBLICATION NO. 590). 
  

			
	Very truly yours,
	
	(Name of Issuing Bank)
		
	By:	 	  

  

					
		 	 EXHIBIT F
  

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	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 EXHIBIT G 

SAN RAFAEL CORPORATE CENTER 
 RIGHT TO LEASE ADJACENT BUILDING AGREEMENT 
 THIS RIGHT TO LEASE ADJACENT BUILDING
AGREEMENT (this “Agreement”) is made and entered into as of December 31, 2011, by and between SR CORPORATE CENTER PHASE TWO, LLC, a Delaware limited liability company (“Landlord”), and BIOMARIN
PHARMACEUTICAL INC., a Delaware corporation (“Tenant”). 
 RECITALS 

 

	A.	Concurrently herewith, Landlord and Tenant are entering into a Lease for the entire building located at 770 Lindaro Street (the “770 Lease”) and
a Lease of space within the building at 790 Lindaro Street (the “790 Lease”, and collectively with the 770 Lease, the “Leases”), in San Rafael, California (collectively the “Premises”). The Premises
are located in two of the buildings in a project known as “San Rafael Corporate Center” (the “Project”). 

  

	B.	Landlord is the owner of property in the Project at 791 Lincoln Avenue, San Rafael, California, which is adjacent to the Premises (the “Development
Site”). 

  

	C.	The Development Site is currently entitled for the construction of one (1) four (4) story building consisting of approximately 83,040 square feet (the
“New Building”). In conjunction with the construction of the New Building, Landlord intends to construct a parking garage at 788 Lincoln Avenue, San Rafael, California for use by tenants of the Project and not the public (the
“Parking Garage”). 

  

	D.	Landlord has completed final working drawings for the New Building, which have been approved by the City of San Rafael and are ready to submit for building permits (the
“Existing Plans”), as described on Schedule 1 attached hereto. 

  

	E.	In connection with the Lease, Landlord has agreed to grant to Tenant a right to lease the New Building to be exercise on or before December 20, 2012, as provided
in this Agreement, for a fixed period of time pursuant to the 770 Lease and on the terms and conditions set forth in this Agreement. 

 NOW, THEREFORE, in consideration of the above recitals which by this reference are incorporated herein, the mutual covenants and conditions contained herein and other valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree as follows: 

 1. Defined Terms. 

As used in this Agreement, the following capitalized terms have the following meanings: 

Allowance: See definition in Section 9.2.10. 
 Approved Plans: The Final Working Drawing as approved by both Landlord and Tenant in accordance with this Agreement. 
 Architect: The architect selected by Landlord and approved by Tenant (which approval shall not be unreasonably withheld or delayed), with respect to the Landlord’s Work. 

Bidding Contractor(s): See definition in Section 7. 
 Building Shell: The shell of the New Building, as shown on the Existing Plans (as the same may be modified pursuant to the process of development and approval of the Approved Plans). 

Change Order: Any changes, alterations or additions to the Approved Plans with respect to any of Landlord’s Work
(“Change Order”). 
 Commencement of Construction: See definition in Section 8. 

Commissions: See definition in Section 9.2.9. 
 Construction Financing: See definition in Section 9.2.3. 

Contractor: See definition in Section 7. 
 Customary Fees: See definition in Section 9.2.2. 
 Development
Costs: See definition in Section 9.2. 
 Development Documents: means that certain Planned Development (PD-1754)
Zoning District, Master Use Permit and Development Agreement for the San Rafael Corporate Center, dated February 17, 1998, recorded April 9, 1998, as Instrument Number 89-023245 (as amended to date). 

Development Site: See definition in Recital B. 
 Governmental Fees: See definition in Section 9.2.5. 
 Estimated
Construction Schedule: See definition in Section 3.1.2. 
 Exclusive Right to Lease: See definition in Section 2.

 Final Completion Certificate: See definition in Section 10.1. 

Final Working Drawings: See definition in Section 5.2. 

Force Majeure: Any prevention, delay or stoppage due to strikes, lockouts, labor disputes, acts of God, inability to obtain
services, labor, or materials or reasonable substitutes therefor, governmental actions, civil commotions, fire or other casualty, and other causes beyond the reasonable control of the party obligated to perform, except with respect to the
obligations imposed with regard to charges to be paid by Tenant pursuant to this Agreement. 

 General Contract: See definition in Section 7.3. 

General Contractor: The general contractor selected by Landlord and approved by Tenant (not to be unreasonably withheld or
delayed), with respect to Landlord’s Work, the Site Improvements and the Tenant Improvements. 
 Governmental Review
Process: See definition in Section 6. 
 Landlord Delay: Any of the following types of delay in the completion
of construction of the Tenant Improvements: 
 Any delay resulting from Landlord’s failure to furnish, in a timely manner,
information requested by Tenant or by the Architect or General Contractor in connection with Tenant’s preparation of the Tenant’s Initial Plans, or from Landlord’s failure to approve in a timely manner any matters requiring approval
by Landlord; or 
 Any delay of any other kind or nature caused by Landlord (or Landlord’s contractors, agents or
employees) or resulting from the performance of Landlord’s Work. 
 No Landlord Delay shall be deemed to have occurred
unless the applicable delay continues for more than two (2) business days following written notice of the delay from Tenant to Landlord. 
 Landlord Parties: See definition in Section 12.10. 

Landlord’s Work: The New Building and Site Improvements as shown on the Existing Plans, or on the Approved Plans, or which
Landlord otherwise agrees to construct or install pursuant to this Agreement by mutual agreement of Landlord and Tenant from time to time. 
 New Building Commencement Date: The date that five (5) days after Landlord delivers the Final Completion Certificate and the New Building to Tenant in the New Building Substantial Completion
Condition. 
 New Building Approvals means the governmental approvals Landlord covenants to obtain pursuant to
Section 6 below. 
 New Building Carry: See definition in Section 9.2.6. 

New Building Exercise Notice: See definition in Section 4. 

New Building Information: See definition in Section 3.1. 

New Building Interest Notice: See definition in Section 2.1. 

New Building Land: means the land contained within Tax Parcel 013-012-51. 

New Building Land Value: See definition in Section 7.1. 

 New Building Lease: See definition in Section 11.1. 

New Building Permit: means a permit issued by the City of San Rafael to permit construction of the Landlord’s Work.

 New Building Rent: See definition in Section 7. 

New Building Return on Costs: See definition in Section 9. 

New Building Substantial Completion Condition: See definition in Section 10.1. 

New Building Substantial Completion Date: See definition in Section 68 

New Building Term: See definition in Section 11.2. 
 Notice: See definition in Section 12.5. 
 Offsite/Impact Costs:
See definition in Section 9.2.5. 
 Permitted Use: General executive and administrative office space, research
and development, basic biology and chemistry lab functions, laboratory use, and ancillary fitness center and cafeteria for employees and invitees of Tenant. 
 Proforma Estimate: See definition in Section 3.1.1. 
 Project Costs:
See definition in Section 9. 
 Punch List Work: Minor corrections of construction or decoration details, and minor
mechanical adjustments, that are required in order to cause any applicable portion of the Landlord’s Work as constructed to conform to the Approved Plans in all material respects and that do not materially interfere with Tenant’s use or
occupancy of the Buildings and the Property. 
 Rescission Notice: See definition in Section 6. 

Restricted Changes: Any changes (i) to the location of the elevator shafts in the New Building, (ii) that would require
the removal of the piles that have already been installed at the Development Site, and (iii) any changes of the nature of the New Building from a first class general officer, research and development, and laboratory space building. 

Security Agreement: See definition in Section 12.10. 

Security Holder: See definition in Section 12.10. 
 Site Improvements: The parking areas, driveways, landscaping and other improvements to the Common Areas of the Property that are depicted on the Existing Plans (as the same may be modified pursuant
to the process of development and approval of the Approved Plans). 

 Tenant Delay: Any of the following types of delay in the completion of construction
of the any Improvements Landlord is required to construct in accordance with this Agreement: 
 Any delay resulting from
Tenant’s failure to furnish, in a timely manner, information requested by Landlord or by the Architect or General Contractor for Landlord’s Work in connection with the design or construction of the Building Shells, or from Tenant’s
failure to approve in a timely manner any matters requiring approval by Tenant; 
 Any delay resulting from Change Orders by
Tenant, including any delay resulting from the need to revise any drawings or obtain further governmental approvals as a result of any Change Order by Tenant; or 
 Any delay of any other kind or nature caused by Tenant (or Tenant’s contractors, agents or employees). 
 No Tenant Delay shall be deemed to have occurred unless the applicable delay continues for more than two (2) business days following written notice of the delay from Landlord to Tenant. 

Tenant Improvements: The improvements to or within the New Building, other than improvements constituting part of Landlord’s
Work, to be constructed by Tenant in the New Buiilding at Tenant’s sole cost and expense (subject to Landlord’s contribution of the Tenant Improvement Allowance) in accordance with the terms of the New Lease. 

Tenant’s Initial Plans: Plans and specifications based on the Existing Plans to be prepared by Tenant’s architect at
Tenant’s cost depicting Tenant’s conception of the Landlord’s Work and Tenant’s proposed modifications to the Existing Plans, provided that the Conceptual Plans shall be stylistically consistent with the exterior architecture of
the remainder of the Project and otherwise consistent with the Development Documents, and which shall not include and “Restricted Changes” as defined above. Ata minimum, the Tenant’s Initial Plans shall be complete and detailed
enough, with elevations and specifications completed to the extent required to allow for (1) design review and planning commission review (the “Initial City Approvals”), and (2) receipt of a detailed pricing bid for the
construction of all of the Landlord’s Work shown on the Tenant’s Initial Plans. At Tenant’s option, the Tenant’s Initial Plans may be complete to the extent required to be Final Working Drawings. 

Winning Bid: The bid of the Contractor as described in Section 7. 

Work Deadlines: The target dates for performance by the applicable party of the steps listed in the Estimated Construction
Schedule. 
 Capitalized terms not otherwise defined in this Agreement shall have the definitions set forth in the Lease to
which this Agreement is attached as an Exhibit (the 770 Lindaro Lease). 
 2. Exclusive Right to Lease.
Landlord hereby grants Tenant an exclusive right to lease the entire New Building on the terms and conditions set forth in this Agreement (the “Exclusive Right to Lease”), during the period commencing on the date hereof, and
continuing through the final date upon which Tenant may deliver the New Building Exercise Notice (which, subject to the terms of Section 4, below, is scheduled to be December 20, 2012). Tenant may only lease the New Building in its
entirety. 

 2.1 Notice of Interest; Delivery Date of New Building
Information. If Tenant is interested in leasing the New Building, Tenant shall deliver written notice of interest to Landlord, which shall include Tenant’s Initial Plans (collectively the “New Building Interest Notice”)
on or before November 15, 2012. Without in any way limiting Tenant’s rights hereunder, Tenant shall endeavor to provide Landlord with one or more drafts of the Tenant’s Initial Plans prior to submitting the New Building Interest
Notice, and if any such drafts are produced, Landlord and Tenant agree to meet and discuss such drafts. The New Building Interest Notice shall state conspicuously that it is a “NEW BUILDING INTEREST NOTICE.” If Tenant timely delivers the
New Building Interest Notice, then, no later than December 15, 2012, Landlord shall deliver to Tenant the New Building Information in response to the New Building Interest Notice. 

3. New Building Information. 
 3.1 The “New Building Information” shall consist of the following. 
 3.1.1 Proforma Estimate. The New Building Information shall include Landlord’s reasonable estimate of all relevant “Project Costs,” as that term is defined in
Section 9, below (the “Proforma Estimate”), for the Landlord’s Work, based on the Tenant’s Initial Plans, which Proforma Estimate shall, at a minimum, include the categories and be presented in the manner set
forth on the form attached hereto as Exhibit A. 
 3.1.2 Estimated Construction
Schedule. The New Building Information shall include Landlord’s estimated schedule for (i) the preparation of Final Working Drawings which shall be sufficiently complete to allow subcontractors and providers of materials to bid on
the work and to obtain all applicable permits, and to produce the construction schedule (which may be amended by Landlord from time-to-time) (the “Estimated Construction Schedule”) (ii) completing the design review and planning
commission (and city council, if applicable) approval process, including any approvals required pursuant to Applicable Law and the Development Documents for the construction of the New Building and the allowance of the Permitted Use (the
“Initial Approvals”), (iii) bidding the New Building Final Working Drawings to general contractors and subcontractors for construction, bid validation and selection, and negotiation and execution of the General Contract (as
defined in Section 4.5), (iv) receiving all necessary building permits and other ministerial governmental and third party approvals required in order to commence and fully complete the Landlord’s Work, and (v) demolishing
the existing improvements, and constructing the Landlord’s Work. The Estimated Construction Schedule shall contain the anticipated dates, as reasonably projected by Landlord, by which the various plan preparation, bidding, contractor selection
and construction Work Deadlines for the Landlord’s Work are expected to be achieved, as well as any time periods contemplated by this Agreement for obtaining any required material approvals or consents by Landlord, Tenant or other third
parties, as the case may be. 
 4. Notice of Exercise. If Tenant desires to lease the New Building based on
its review of the New Building Information, Tenant shall deliver written notice to Landlord approving the New Building Information and evidencing Tenant’s exercise of its Exclusive Right to Lease (the “New Building Exercise
Notice”) no later than December 20, 2012, which date shall be extended on a day-for-day basis for each day past December 15, 2012, Landlord 

 
delivers the New Building Information to Tenant. The New Building Exercise Notice shall state conspicuously that it is a “NEW BUILDING EXERCISE NOTICE.” After delivery of the New
Building Exercise Notice, subject to Landlord’s compliance with its obligations and completion of the Landlord’s Work as required hereunder and subject to all other terms and conditions of this Agreement, Tenant shall be obligated to lease
the New Building commencing on the New Building Commencement Date, subject only to Tenant’s rescission right set forth in Section 6 below. 
 5. “Pre-Construction Actions. If Tenant timely delivers the New Building Exercise Notice, Landlord and Tenant shall work together in good faith in connection with the following:

 5.1 Architectural Agreement. Landlord shall have no obligation to prepare the Tenant’s
Initial Plans. Tenant shall, at Tenant’s option, engage Architect pursuant to a commercially reasonable and customary architectural agreement, reasonably approved by Landlord, to prepare the Tenant’s Initial Plans at Tenant’s sole
cost and expense. If Tenant delivers the New Building Exercise Notice, then promptly following Tenant’s delivery of the New Building Exercise Notice, Tenant shall assign to Landlord (without relasing Architect from its obligations to Tenant, or
waiving any rights of Tenant under such contract) all of Tenant’s rights and obligations under its contract with the Architect (provided that Tenant shall remain obligation to pay all amounts incurred or applicable to work performed by
Architect prior to the date of such assignment, which amounts shall not be included within the definition of Project Costs for the purposes of determining the new Building Rent). 

5.2 New Building Final Working Drawings. Following the assignment of the contract with the Architect
from Tenant to Landlord, Landlord shall promptly and diligently cause the Architect to modify the Tenant’s Initial Plans as required to cause such Tenant’s Initial Plans to be final working drawings and specification for the
Landlord’s Work, including structural, fire protection, life safety, mechanical and electrical working drawings and final architectural drawings (collectively, “Final Working Drawings”). During the course of the preparation of
the Final Working Drawings, Architect shall receive Tenant’s approval to any material modifications of the Tenant’s Initial Plans, and to any and all material decisions regarding materials, finishes and specifications required for the
Final Working Drawings that were not including in the Tenant’s Initial Plans. Landlord shall use commercially reasonable, diligent efforts to deliver Final Working Drawings to Tenant within the time period set forth in the Estimated
Construction Schedule. No later than the applicable Work Deadline set forth in the Estimated Construction Schedule (assuming timely delivery of plans and drawings by Landlord), Tenant shall either approve the Final Working Drawings or set forth in
writing with particularity any changes required by Tenant to bring the Final Working Drawings into a form which will be acceptable to Tenant. In no event, however, shall Tenant have the right to object to any aspect of the proposed plans and
specifications or proposed Final Working Drawings for Landlord’s Work that is necessitated by applicable laws. Failure of Tenant to deliver to Landlord written notice of disapproval and specification of required changes on or before the
applicable Work Deadline set forth in the Estimated Construction schedule shall contritute and be deemed to be approval of the Final Working Drawings. Upon approval, actual or deemed, of the Final Working Drawings by Landlord and Tenant, the Final
Working Drawings shall be deemed to be the Approved Plans. 

 5.3 Mutual Cooperation. At each stage during the
process of preparing the Tenant’s Initial Drawings and the Final Working Drawings, Landlord and Tenant shall regularly communicate regarding the status of the design and construction documents related thereto, and provide each other the
opportunity to comment on such documents. Without limiting any provisions of this Agreement, Tenant shall be entitled to attend all substantial meetings between Landlord and its Architect and General Contractor, and through such communications and
meetings Landlord shall make reasonable efforts to accommodate Tenant’s comments on the draft design and construction documents in order to make Tenant’s approval process set forth in Section 5.2 as efficient as possible. 

6. Initial City Approvals. Following Tenant’s delivery of the New Building Exercise Notice, the parties shall
work together in good faith to submit the Tenant’s Initial Plans for review and approval of the applicable governmental entities for receipt of the Initial City Approvals (“Governmental Review Process”). In the event that
during the Governmental Review Process, either at the design review stage or the planning department stage, material changes to the Tenant’s Initial Plans or Permitted Use are required as a condition of the Initial City Approvals, Tenant shall
have the right to rescind its New Building Exercise Notice by giving written notice of rescission (“Rescission Notice”) to Landlord within five (5) business days following Landlord’s written notice of such conditions to
Tenant, and following such rescission the parties shall have no further rights or obligations under this Agreement. If the Initial City Approvals have not been obtained by September 30, 2013, then either party may terminate this Agreement by
giving written notice to the other party and following such termination the parties shall have no further rights or obligations under this Agreement. Tenant shall be responsible for all filing fees and other payments to the City of San Rafael
incurred in connection with the Governmental Review Process. If this Agreement is terminated as provided in this Section 6, Tenant shall reimburse Landlord any reasonable costs incurred by Landlord in connection with the Governmental
Review Process (provided that Landlord shall obtain Tenant’s approval prior to incurring any such costs). For the purposed of this Section 6, the term “material change” shall mean any change to the submitted Tenant’s Initial
Plans imposed as a condition of approval during the Governmental Review Process which would impair Tenant’s ability to use the New Building for the purposes for which it is intended, would increase Tenant’s costs or expenses by more than
five percent (5%), or which would substantially impair the aesthetics or functionality of the interior portions of the New Building as described by the submitted Tenant’s Initial Plans, each as reasonably and in good faith determined by Tenant.

 7. Selection of General Contractor; Winning Bid. Following the completion of the Final Working Drawings,
Landlord shall select three (3) qualified general contractors, subject to Tenant’s approval, which shall not be unreasonably withheld, or delayed (each a “Bidding Contractor,” and, collectively, the “Bidding
Contractors”), that shall bid on the construction of the Landlord’s Work. Each of the Bidding Contractors shall submit a bid that includes (i) fees for general conditions, profit and overhead, (ii) such Bidding
Contractor’s agreement to abide by the relevant portions of the Estimated Construction Schedule which relate to the Bidding Contractor’s scope of work in connection with the construction of the Landlord’s Work, and (iii) such
Bidding Contractor’s agreement to construct the Landlord’s Work in accordance with the approved Final Working Drawings and to comply with the terms of the “General Contract,” as that term is defined in Section 5.6,
below. Landlord shall select 

 
the winning general contractor (the “Contractor”) from among the Bidding Contractors that Landlord reasonably determines have submitted qualified proposals which were consistent
with the bid assumptions and directions. The bid of the selected Contractor shall be referred to herein as the “Winning Bid”. If the Winning Bid is more than five (5%) greater than the amount set forth in the Proforma Estimate,
Landlord and Tenant shall work cooperatively with the Architect and Contractor to make such Change Orders as approved by Tenant in order to reduce the cost of such work. 

7.1 Selection of Major Subcontractors. Landlord shall cause the Contractor to bid (such bidding shall take
into consideration any Landlord caused Change Orders and any Tenant caused Change Orders) each of the major trades (as reasonably determined by Landlord) with at least three (3) qualified subcontractors (to the extent that three (3) such
qualified subcontractors are available to perform the work in accordance with the Estimated Construction Schedule and, if three (3) such subcontractors are not available, by at least two (2) of such subcontractors). Landlord shall, within
ten (10) business days following the date upon which Landlord delivers such subcontractors bids to Tenant, select the winning subcontractor for each major trade from among the subcontractors that Landlord reasonably determines have
(a) submitted qualified bids which were consistent with the bid assumptions and directions, (b) have committed to the Estimated Construction Schedule, and (c) will comply with applicable terms of the General Contract. 

7.2 Pre-Ordering of Long Lead-Time Items. To the extent that some items of construction must be pre-ordered
in order to allow the construction of the Landlord’s Work or the Landlord’s Work to comply with the Estimated Construction Schedule, Landlord may cause such items to be competitively bid, in a manner consistent with that used for the
competitive bidding of the remainder of the Landlord’s Work, in advance of the execution of the General Contract. 
 7.3 Construction Contract. Landlord shall then enter into an AIA A111 or A133 (as reasonably modified by Landlord) and AIA A201 (as reasonably modified by Landlord) construction contract
(more commonly known as a “Cost of the Work Plus a Fee with Guaranteed Maximum Price” construction contract) with the Contractor based upon Winning Bid (the “General Contract”). Landlord shall enforce the terms of the
General Contract, in a commercially reasonable manner, with respect to the Contractor’s obligations including, without limitation, obligations with respect to pricing and the construction schedule. The General Contract shall provide that any
Changes Orders shall be set forth in writing. 
 8. Construction of Landlord’s Work. Landlord shall
use commercially reasonable and diligent efforts to meet the Work Deadlines set forth in the Estimated Construction Schedule for completion of the Landlord’s Work. In the event Tenant delivers a New Building Exercise Notice, then Landlord shall
use commercially reasonable and diligent efforts to commence construction of the Landlord’s Work (i.e., demolition of the existing improvements) within thirty (30) days after Landlord’s receipt of the applicable permits (except as
otherwise set forth on the Estimated Construction Schedule) (the “Commencement of Construction”). Landlord shall use commercially reasonable and diligent efforts to complete construction of the Landlord’s Work and deliver the
New Building to Tenant in the “New Building Substantial Completion Condition,” as that term is defined in Section 10, 

 
below, on or before the date shown on the Estimated Construction Schedule for substantial completion (the “New Building Substantial Completion Date”) (subject to delays caused by
Force Majeure, or other matters that were not reasonably foreseeable to Landlord at the time that Landlord delivered the Preliminary New Building Information Notice to Tenant or except as otherwise set forth on the Estimated Construction Schedule).
Notwithstanding any contrary provision set forth in this Agreement, the New Building Substantial Completion Date shall be delayed by one day for every day of delay caused by (i) Tenant Delays and (ii) delays due to “Force
Majeure,” as that term is defined in the Lease. During construction of the Landlord’s Work, Tenant shall have the right to attend construction meetings and inspect the progress of the work, so long as such action does not delay the
construction schedule. 
 9. New Building Rent. The rent payable by Tenant for the New Building (the
“New Building Rent”) shall equal, on an annual basis, (1) the “Base Rent”, which shall initially be equal to the product of (i) the “Project Costs,” as that term is defined below, and
(ii) nine percent (9%) (the “New Building Return on Costs”) and (2) one hundred percent (100%) of the Direct Expenses for the New Building for the calendar year in which the New Building Commencement Date occurs,
and thereafter for each calendar year during the Lease Term, and (3) a pro rata share of common Direct Expenses associated with the Project. The Base Rent shall be increased on an annual basis during the Lease Term equal to 103.5% of the Base
Rent attributable to the prior year. As used herein, the term “Project Costs” shall mean an amount equal to the sum of the amounts set forth in Sections 9.1, 9.2 and 9.3 below. Irrespective of whether Tenant exercises the
Exclusive Right to Lease, any costs incurred by Landlord in connection with the construction of the Landlord’s Work shall be paid by Landlord (without reimbursement from Tenant, except for Tenant caused Change Orders which actually increase
Project Costs over the amount set forth in the approved Winning Bid), and Tenant’s sole obligation with respect to such costs shall be to pay the New Building Rent if Tenant delivers the New Building Exercise Notice. Any costs reimbursed to
Landlord by Tenant for Tenant caused Change Orders, or any other costs or charges that are reimbursed by Tenant (or paid directly by Tenant) shall be excluded from Project Costs. 

9.1 New Building Land Value. A land value (“New Building Land Value”) equal to
$$4,982,400.00. 
 9.2 Development, Design and Construction Costs. Expressly excluding fees
and costs payable by Tenant under Sections 5.1 and/or Section 6 above, all costs, fees and expenses reasonably incurred in connection with the design, development and construction of the Landlord’s Work (including associated common areas,
walkways, parking, landscaping, and related improvements required to complete Landlord’s Work), and in obtaining all permits, approvals, authorizations and licenses required to construct the Landlord’s Work (the “Development
Costs”), including, without limitation, the following. 
 9.2.1 Design Fees. All
architectural (including landscape architecture), engineering, and other design consulting fees attributable solely the Landlord’s Work. 

 9.2.2 Governmental Fees. All permit fees and costs charged by
the City or other applicable governmental authorities with jurisdiction that are required to be paid to construct a building which can be used for the Permitted Uses set forth in the Lease to which this Agreement is attached, including such costs
related to the [amendment of the Development Agreement and related use permits], plan check, permitting, inspecting, bonding, constructing, and utilities and services for the Landlord’s Work (collectively, the “Customary
Fees”). 
 9.2.3 Financing. The sum of (i) all interest and loan fees and
actual costs payable by Landlord on any construction loan or loans obtained by Landlord for the construction of the Landlord’s Work, the terms of which have been approved in writing by Tenant, such approval not to be unreasonably withheld or
delayed (the “Construction Financing”) to the extent incurred from the closing of the Construction Financing until the New Building Commencement Date, and (ii) all interest on debt financing obtained by Landlord in its
acquisition of the New Building Land and the Development Site to the extent reasonably allocable to the New Building Land and secured by the Project and the Development Site from the date Tenant delivers the New Building Exercise Notice until the
time such Construction Financing is obtained. Notwithstanding the foregoing, any costs incurred by Landlord on account of late charges, penalties, default interest, and prepayment or defeasance penalties, payments, costs or fees associated with such
financing shall be excluded from Development Costs. Landlord shall use commercially reasonable efforts to obtain Construction Financing on terms not less favorable than the generally prevailing terms for comparable loans, taking into account all
customary and reasonable factors, including without limitation the appraised value of the Development Site and the Project. 
 9.2.4 Contractor’s Fees. All fees and charges of the Contractor as set forth in the General Contract and approved in writing by Tenant, such approval not to be unreasonably
withheld or delayed. 
 9.2.5 Entitlement Fees and Offsite/Impact Costs. All fees (including
zoning fees), exactions and other expenses and costs incurred in obtaining the New Building Entitlements (the “Entitlement Fees”), and costs of complying with conditions of approval or mitigation requirements relating to offsite
infrastructure costs, traffic improvements, and other off-site impacts other than any amounts attributable to the presence of hazardous materials (the “Offsite/Impact Costs”). 

9.2.6 New Building Cost Carry. The “New Building Cost Carry” shall be an amount equal to
the sum of (i) “Tax Expenses,” as that term is defined in Section 4.1.5 of the Lease to which this Agreement is attached, to the extent reasonably allocable to the New Building Land and incurred by Landlord from the time from the
date Tenant delivers the New Building Exercise Notice until the New Building Commencement Date, (ii) the cost of obtaining reasonable liability insurance attributable to the New Building and incurred by Landlord from the time from the date
Tenant delivers the New Building Exercise Notice until the New Building Commencement Date, and (iii) reasonable site maintenance and security costs, and similar site specific expenditures incurred by Landlord from the time from the date Tenant
delivers the New Building Exercise Notice until the New Building Commencement Date, and (iv) a nine percent (9%) per annum return to Landlord on all Development Costs paid by Landlord (not including Development Costs paid from the proceeds
of any Construction Loan) during the period from the date Tenant delivers the new Building Exercise Notice to the New Building Commencement Date. 

 9.2.7 Development Fee. A development fee in an amount
equal to four percent (4%) of the total Development Costs, excluding the financing costs referred to in Section 7.2.3. 
 9.2.8 Consultant Costs. All reasonable costs arising from consultants reasonably retained by Landlord in connection with the development, design, permitting and construction of the
Landlord’s Work, including, without limitation, legal, accounting, construction and other professional and consultant fees, costs and expenses. 
 9.2.9 Commissions. All real estate brokerage commissions paid by Landlord to any broker retained by Tenant in connection with Tenant’s lease of the New Building (the
“Commissions”). 
 9.2.10 Tenant Improvement Allowance. An improvement
allowance to be provided by Landlord to Tenant to be used for the construction of Tenant’s improvements in the New Building in an amount equal to $60.00 per rentable square foot of the New Building (the “Allowance”), which
Allowance shall be prorated based on the term of the Lease for the New Building. 
 9.2.11
Demolition and Remediation Costs. All costs incurred to demolish and remove the existing structures on the Development Site in compliance with all applicable laws, as required for the construction of the Landlord’s Work and
receipt of all governmental approvals to allow for the use of the New Building for the Permitted Use. 
 9.3
Parking Garage; Project Common Areas. The Project Costs shall include a percentage of all of the applicable costs incurred for construction of the Parking Garage, which percentage shall have a numerator equal to the rentable square
footage of the New Building, a denominator equal to the rentable area of the entire Project. Based on the currently estimated square footage of the new Building, such percentage is 20.901% (83,040 / 397,294). 

9.4 Tenant’s Audit of Project Costs. Tenant shall have the right to review all documentation
relating to the Project Costs incurred by Landlord on an “open book” basis. In that regard, Landlord shall make reasonably available for Tenant’s review and copying all material invoices, applications for payment, and other material
books, records and other documentation evidencing the Project Costs incurred by Landlord. Once Landlord has made a final determination of New Building Rent, Landlord shall deliver such final determination to Tenant. Tenant shall pay the New Building
Rent as determined by Landlord commencing on the New Building Commencement Date. Thereafter, if Tenant disputes the calculation of the New Building Rent, Landlord and Tenant shall meet and attempt to reconcile any differences regarding the
determination of the New Building Rent. If Landlord and Tenant are still unable to agree on the calculation of Project Costs, within sixty (60) days after Tenant receives such determination by Landlord, if so requested by Tenant, a
determination as to the actual amount of Project Costs shall be made, at Tenant’s expense (except as otherwise provided below), by an independent construction management firm (as applicable, the “Project Costs Accountant”)
selected by the parties. If Landlord and Tenant are unable to agree on the Project Costs Accountant, then the parties shall apply to JAMS, Inc., for appointment of the 

 
Project Costs Accountant. If the Project Costs Accountant determines that the Project Costs were equal to an amount which is different than the Project Costs amount determined by Landlord, then
Landlord and Tenant shall, within thirty (30) days following such determination by the Project Costs Accountant, reconcile the amount of New Building Rent that has already been paid by Tenant, if any, with the amount of New Building Rent which
should have been paid by Tenant, if any, and the Project Costs determined by the Project Costs Accountant shall be used, thereafter, to calculate New Building Rent. If the New Building Rent as calculated by the Project Costs Accountant is less than
the New Building Rent calculated by Landlord, Landlord shall reimburse Tenant for the costs of the Project Costs Accountant. 

10. Completion. 
 10.1 When Landlord receives written certification from Architect that construction of the Landlord’s Work has been substantially completed in accordance with the Approved Plans (except for
Punch List Work), Landlord shall prepare and deliver to Tenant a certificate signed by both Landlord and Architect (the “Final Completion Certificate”) certifying that the construction of the Improvements constituting
Landlord’s Work has been substantially completed in compliance with all applicable laws, in good and workmanlike manner and in accordance with the Approved Plans in all material respects, subject only to completion of Punch List Work
(“New Building Substantial Completion Condition”), and specifying the date of that completion. Upon delivery of the Final Completion Certificate, the Landlord’s Work will be deemed delivered to Tenant for all purposes of the
Lease (subject to Landlord’s continuing obligations with respect to the Punch List Work). 
 10.2 At
any time within forty-five (45) days after delivery of the Final Completion Certificate, Tenant shall be entitled to submit one or more lists to Landlord specifying Punch List Work to be performed on the applicable Improvements constituting
Landlord’s Work, and upon receipt of such list(s), Landlord shall diligently complete such Punch List Work at Landlord’s sole expense (which costs shall be included in Project Costs). Promptly after Landlord provides Tenant with the Final
Completion Certificate, Landlord shall cause the recordation of a Notice of Completion (as defined in Section 3093 of the California Civil Code) with respect to Landlord’s Work. 

11. New Lease. 
 11.1 In General. If Tenant timely exercises Tenant’s Exclusive Right to Lease the New Building as set forth herein, Landlord and Tenant shall promptly thereafter negotiate in
good faith and execute a new lease in connection with Tenant’s lease of the New Building (the “New Building Lease”). The New Building Lease shall be in substantially the same form as the 770 Lease, provided that (a) such
form shall be modified to incorporate the terms and conditions contained in this Section 11, (b) both the New Building Lease and the 770 Lease shall contain cross-default provisions providing that a default under either of the
leases shall constitute a default under the other lease, and (c) such New Building Lease shall not include any provisions in the 770 Lease which by their terms are clearly not applicable to the New Building Lease. The New Building Lease shall
(1) require Tenant to deliver to Landlord a Letter of Credit, concurrently with the execution of the New Building Lease, in the initial amount of Three Million Two Hundred Fifty Thousand Dollars ($3,250,000.00) to be held by

 
Landlord on terms comparable to those in Article 21 of the Lease (provided that the reductions in the amount of the Letter of Credit shall be proportional to the reductions in the letter of
credit held under the Lease, and shall commence after the first (1st) year of the New Building Lease), and (2) shall provide rights to renew the lease term similar to the rights provided in the 770 Lease. In the event that despite their good faith efforts
Landlord and Tenant fail to fully agree upon and execute and deliver the New Building Lease within sixty (60) days after Tenant’s delivery of the New Building Exercise Notice, then Landlord and Tenant shall submit any remaining unresolved
points to binding arbitration using JAMS, with the instruction that the arbitrator determine a customary market compromise provision with respect to each unresolved point. Landlord shall have no obligation to commence construction of the
Landlord’s Work until the New Building Lease is fully executed and delivered, subject only to the rescission right provided in Section 4, above. 

11.2 Term. Tenant shall commence payment of Rent for the New Building, and the term of the New
Building Lease (the “New Building Term”) shall commence, on the New Building Commencement Date and shall continue for a period of ten (10) years, subject to the terms of the New Building Lease. 

11.3 Termination of Exclusive Right to Lease. The Exclusive Right to Lease contained in this Agreement shall
be personal to the named Tenant or an Affiliate Assignee, as defined in the 770 Lease. Tenant shall not have the option to lease the New Building, as provided in this Agreement, if, as of the date of the attempted exercise of such right, Tenant is
in default under the 770 Lease (beyond any applicable notice and cure periods). 
 12. Miscellaneous. 

12.1 Entire Agreement. This Agreement and the attached exhibits, which are hereby incorporated into and made
a part of this Agreement, set forth the entire agreement between the parties with respect to the matters set forth herein. There have been no additional oral or written representations or agreements. 

12.2 Not An Offer. Submission of this Agreement by Landlord is not an offer to enter into this
Agreement but rather is a solicitation for such an offer by Tenant. Neither Landlord nor Tenant shall be bound by this Agreement until both Landlord and Tenant have executed and delivered this Agreement and the 770 Lease to the other. This Agreement
may be executed in counterparts, each of which shall be deemed a part of an original and all of which together shall constitute one (1) agreement. Signature pages may be detached from the counterparts and attached to a single copy of this
Agreement to form one (1) document. 
 12.3 Brokers. Tenant shall indemnify and hold
Landlord, its trustees, members, principals, beneficiaries, partners, officers, directors, employees, mortgagee(s) and agents, and the respective principals and members of any such agents harmless from all claims of any brokers claiming to have
represented Tenant in connection with this Agreement other than the Brokers. Landlord will pay the Brokers commission due in connection with the Lease of the New Building, if any, pursuant to a separate agreement. Landlord shall indemnify and hold
Tenant, its trustees, members, principals, beneficiaries, partners, officers, directors, employees, and agents, and the respective principals and members of any such agents harmless 

 
from all claims of any brokers claiming to have represented Landlord in connection with this Agreement. Tenant acknowledges that any assistance rendered by any agent or employee of any affiliate
of Landlord in connection with this Agreement has been made as an accommodation to Tenant solely in furtherance of consummating the transaction on behalf of Landlord, and not as agent for Tenant. 

12.4 Authority. Each party hereby represents hereby that the signatory signing on its behalf has the
authority to execute and deliver the same on its behalf. 
 12.5 Notices. No notice, demand,
statement, designation, request, consent, approval, election or other communication given hereunder (“Notice”) shall be binding upon either party unless (a) it is in writing; (b) it is (i) sent by certified or
registered mail, postage prepaid, return receipt requested, (ii) delivered by a nationally recognized courier service, or (iii) delivered personally; and (c) it is sent or delivered to the address set forth below, as applicable, or to
such other place (other than a P.O. box) as the recipient may from time to time designate in a Notice to the other party. Any Notice shall be deemed received on the earlier of the date of actual delivery or the date on which delivery is refused, or,
if Tenant is the recipient and has vacated its notice address without providing a new notice address, three (3) days after the date the Notice is deposited in the U.S. mail or with a courier service as described above. Landlord’s and
Tenant’s initial notice addresses are as set forth in the Lease. 
 12.6 Representations and
Warranties. Tenant and Landlord each hereby represents, warrants and covenants that (a) such party is duly organized, validly existing and in good standing under the laws of the state of its formation and qualified to do business in the
state of California; and (b) neither such party’s execution of nor its performance under this Agreement will cause it to be in violation of any agreement or law. 

Each party shall take any actions that may be required to comply with the terms of the USA Patriot Act of 2001, as
amended, any regulations promulgated under the foregoing law, Executive Order No. 13224 on Terrorist Financing, any sanctions program administrated by the U.S. Department of Treasury’s Office of Foreign Asset Control or Financial Crimes
Enforcement Network, or any other laws, regulations or executive orders designed to combat terrorism or money laundering, if applicable, to this Agreement. Each party represents and warrants to the other party that it is not an entity named on the
List of Specially Designated Nationals and Blocked Persons maintained by the U.S. Department of Treasury, as last updated prior to the date of this Agreement. 
 12.7 Attorney’s Fees. In any action or proceeding between the parties, including any appellate or alternative dispute resolution proceeding, the prevailing party may recover from
the other party all of its costs and expenses in connection therewith, including reasonable attorneys’ fees and costs. 
 12.8 Waiver of Jury Trial. This Agreement shall be construed and enforced in accordance with the laws of the State of California. THE PARTIES WAIVE, TO THE FULLEST EXTENT PERMITTED BY
LAW, THE RIGHT TO TRIAL BY JURY IN ANY LITIGATION ARISING OUT OF OR RELATING TO THIS AGREEMENT. 

 12.9 Severability; Time is of the Essence. If any
provision hereof is void or unenforceable, no other provision shall be affected. If Tenant is comprised of two or more parties, their obligations shall be joint and several. Time is of the essence with respect to the performance of every provision
hereof in which time of performance is a factor. 
 12.10 Security Holders. Notwithstanding
any contrary provision hereof, (a) the liability of the Landlord, its Security Holders (defined below), Landlord’s managing agent(s), their (direct or indirect) owners, and the beneficiaries, trustees, officers, directors, employees and
agents of each of the foregoing (including Landlord, the “Landlord Parties”) to Tenant shall be limited to an amount equal to Landlord’s interest in the Project; (b) no Landlord Party shall have any personal liability for
any judgment or deficiency, and Tenant waives and releases such personal liability on behalf of itself and all parties claiming by, through or under Tenant; and (c) no Landlord Party shall be liable for any injury or damage to, or interference
with, Tenant’s business, including loss of profits, loss of rents or other revenues, loss of business opportunity, loss of goodwill or loss of use, or for any form of special or consequential damage. Conditioned upon Tenant’s receipt of a
reasonable and customary non-disturbance agreement, this Agreement shall be subject and subordinate to all existing and future ground or underlying leases, mortgages, trust deeds and other encumbrances against the Project, all renewals, extensions,
modifications, consolidations and replacements thereof (each, a “Security Agreement”), and all advances made upon the security of such mortgages or trust deeds, unless in each case the holder of such Security Agreement (each, a
“Security Holder”) requires in writing that this Agreement be superior thereto. Upon any termination or foreclosure (or any delivery of a deed in lieu of foreclosure) of any Security Agreement, Tenant, upon request, shall attorn,
without deduction or set-off, to the Security Holder or purchaser or any successor thereto and shall recognize such party as the “Landlord” hereunder. Within 10 business days after written request by Landlord, Tenant shall execute such
further instruments as Landlord may reasonably deem necessary to evidence the subordination or superiority of this Agreement to any Security Agreement. Within 10 business days after Landlord’s written request, Tenant shall execute and deliver
to Landlord a commercially reasonable estoppel certificate in favor of such parties as Landlord may reasonably designate, including current and prospective Security Holders and prospective purchasers. 

IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Agreement as of the day and year first above written. 

 

													
	LANDLORD:	 		 	TENANT:
		 		 		 		 		 	
	SR CORPORATE CENTER PHASE TWO, LLC,
a Delaware limited liability company	 		 	BIOMARIN PHARMACEUTICAL INC.,
a Delaware corporation
					
	By:	 	Seagate SR Corporate Center, LLC,
a California limited liability company	 		 		 	
		 		 		 		 	
		 	By:	 	Seagate Second Street, LLC,	 		 	By:	 	 
		 		 	a California limited liability company	 		 	Name:	 	
		 		 		 		 	Its:	 	

													
		 	By:	 	Seagate Lindaro, LLC,
a California limited liability company	 		 		 	
		 		 		 		 		 		 	
		 	By:	 	 	 		 	By:	 	 
		 		 		 	Willis K. Polite Jr.	 		 	Name:	 	
		 	Its:	 		 	Managing Member	 		 	Its:	 	
		 		 		 		 		 		 	

 EXHIBIT H 

SAN RAFAEL CORPORATE CENTER 
 [VISITOR PARKING DIAGRAM] 

  

					
		 	  
 -1-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 EXHIBIT I 

SAN RAFAEL CORPORATE CENTER 
 [DIAGRAM OF ROOFTOP AREA FOR ANTENNA] 

  

					
		 	  
 -1-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

 EXHIBIT J 

SAN RAFAEL CORPORATE CENTER 
 [DIAGRAMS OF EMERGENCY GENERATOR AREA AND GENERATOR FUEL PAD] 

  

					
		 	  
 -1-
	  	 [SAN RAFAEL CORPORATE CENTER]

[BIOMARIN PHARMACEUTICAL INC.]

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