Document:

Exhibit
      10.15

    Sublease

    

    
      	
              1.

            	
              PARTIES.

            

    

    

    
      	 	
              This
                Sublease, dated May 31, 2006 is made between MJ Research Company,
                Inc.
                (Sublessor"), and Hana Biosciences, Inc.
                ("Sublessee").

            

    

    

    
      	
              2.

            	
              MASTER
                LEASE.

            

    

    

      Sublessor
        is the lessee under a written lease dated November 3, 1999 wherein Mountain
        Cove
        Tech Center LLC ("Lessor) leased to Sublessor the real property located in
        the
        City of South San Francisco, County of San Mateo, State of
        California, described as7000 Shoreline Court. ("Master Premises"). Said lease
        has been amended by
        the
        following amendments: see Amendment to Lease dated October 1, 2004, by and
        between Mountain Cove Tech. Center LLC and MJ Research Incorporated; said
        lease
        and amendments are herein collectively referred to as the "Master Lease"
        and are
        attached hereto as Exhibit "A."

       

    

    
      	
              3.

            	
              PREMISES.

            

    

    

    Sublessor
      hereby subleases to Sublessee on the terms and conditions set forth in this
      Sublease the following portion of the Master Premises ("Premises"): a
      portion
      of the third floor of 7000 Shoreline Court, South San Francisco, California
      94080, consisting
      of 18,788 square feet,
      and
      shown in more detail on Exhibit A, attached hereto and incorporated herein
      by
      this reference. 

    

    
      	
              4.

            	
              WARRANTY
                BY SUBLESSOR.

            

    

    

    Sublessor
      warrants and represents to Sublessee that the Master Lease has not been amended
      or modified except as expressly set forth herein;
      that
      Sublessor is not now, and as of the commencement of the Term hereof will not
      be,
      in default or breach of any of the provisions of the Master Lease;
      that
      Sublessor has no knowledge of any claim by Lessor that Sublessor is in default
      or breach of any of the provisions of the Master Lease. 

    

    
      	
              5.

            	
              TERM.

            

    

    

    The
      Term
      of this Sublease shall commence on the
      later
      to occur of: (i) the date that Sublessor delivers possession of the Premises
      to
      Sublessee together with Lessor’s consent to this Sublease; or (ii) June 1, 2006
      ("Commencement Date") and this Sublease shall terminate thirty-six
      months after June 1, 2006 (“Termination Date"), unless otherwise sooner
      terminated in accordance with the provisions of this Sublease. In the event
      the
      Term commences on a date other than June
      1,
      2006,
      Sublessor and Sublessee shall execute a memorandum setting forth the actual
      date
      of commencement of the Term. Possession
      of the Premises ("Possession") shall be delivered to Sublessee upon
      full
      execution of, and consent to this Sublease.
      If for
      any reason Sublessor does not deliver Possession to Sublessee before
      June 1, 2006,
      Sublessor shall not be subject to any liability for such failure, the
      Termination Date shall not be extended by the delay, and the validity of this
      Sublease shall not be impaired.
      Notwithstanding the foregoing, if Sublessor has not delivered Possession to
      Sublessee within thirty (30) days after June
      1,
      2006,
      then at
      any time thereafter and before delivery of Possession, Sublessee may give
      written notice to Sublessor of Sublessee's intention to cancel this Sublease.
      Said notice shall set forth an effective date for such cancellation which shall
      be at least ten (10) days after delivery of said notice to Sublessor. If
      Sublessor delivers Possession to Sublessee on or before such effective date,
      this Sublease shall remain in full force and effect. If Sublessor fails to
      deliver Possession to Sublessee on or before such effective date, this Sublease
      shall be cancelled, in which case this Sublease shall thereafter be of no
      further force or effect, and Sublessor shall have no further liability to
      Sublessee on account of such delay or cancellation. 

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    
      	
              6.

            	
              RENT.

            

    

    

    6.1 Minimum
      Rent. Commencing
      on the Commencement Date, Sublessee
      shall pay to Sublessor as minimum rent, without deduction, setoff, notice,
      or
      demand, at such place as Sublessor shall designate from time to time by notice
      to Sublessee, the sum of $2.50
      Fully Serviced per square foot per month for months 1-12; $2.60 Fully Serviced
      per square foot per month for months 13 -24; and $2.70 Fully Serviced per square
      foot per month for months 25-36 (or the sum of Forty Six Thousand Nine Hundred
      Seventy Dollars; Forty -Eight Thousand Eight Hundred Forty Eight Dollars and
      Eighty Cents and Fifty Thousand Seven Hundred Twenty Seven Dollars and Sixty
      Cents, respectively ($46,970.00; $48,848.80 & $50,727.60, respectively)) per
      month, in advance on the first day of each month of the Term. Sublessee
      shall pay to Sublessor upon execution of this Sublease the sum of Forty-Six
      Thousand Nine Hundred Seventy Dollars ($46,970.00) as rent for the first month
      of the lease term;
      provided, that if the Term begins on a day after the first day of the first
      month, rent for the first month shall be prorated on a per diem basis. If the
      Term ends on a day other than the last day of a month, the rent for the partial
      month shall be prorated on a per diem basis. Additional provisions:  

    

    6.2
      Operating Costs. See Amendment to Sublease Agreement

    

    
      	
              7.

            	
              SECURITY
                DEPOSIT.

            

    

    

    Sublessee
      shall deposit with Sublessor upon execution of this Sublease the sum of One
      Hundred Twenty Five Thousand Dollars ($125,000.00) as security for Sublessee’s
      faithful performance of Sublessee’s obligations hereunder ("Security Deposit").
      If Sublessee falls to pay rent or other charges when due under this Sublease,
      or
      fails to perform any of its other obligations hereunder, Sublessor may use
      or
      apply all or any portion of the Security Deposit for the payment of any rent
      or
      other amount then due hereunder and unpaid, for the payment of any other sum
      for
      which Sublessor may become obligated by reason of Sublessee's default or breach,
      or for any loss or damage sustained by Sublessor as a result of Sublessee's
      default or breach. If Sublessor so uses any portion of the Security Deposit,
      Sublessee shall, within ten (10) days after written demand by Sublessor, restore
      the Security Deposit to the full amount originally deposited, and Sublessee's
      failure to do so shall constitute a default under this Sublease. Sublessor
      shall
      not be required to keep the Security Deposit separate from its general accounts,
      and shall have no obligation or liability for payment of interest on the
      Security Deposit. In the event Sublessor assigns its interest in this Sublease,
      Sublessor shall deliver to its assignee so much of the Security Deposit as
      is
      then held by Sublessor. Within ten (10) days after the Term has expired, or
      Sublessee has vacated the Premises, or any final adjustment pursuant to
      Subsection 6.2 hereof has been made, whichever shall last occur,
      and
      provided Sublessee is not then in default of any of its obligations
      hereunder,
      the
      Security
      Deposit, or so much thereof as had not theretofore been applied by Sublessor,
      shall be returned to Sublessee or to the last assignee, if any, of Sublessee’s
      interest hereunder.

    

    
      	
              8.

            	
              USE
                OF PREMISES. 

            

    

    

    The
      Premises shall be used and occupied only for general
      office
      andadministrative uses
      and for
      no other use or purpose;
      provided, however, that subject to the terms of the Master Lease, in no event
      shall Sublessee be required to continuously occupy the Premises or to
      continuously operate its business at the Premises,.
      

    

    
      	
              9.

            	
              ASSIGNMENT
                AND SUBLETTING.

            

    

    

    Sublessee
      shall not assign this Sublease or further sublet all or any part of the Premises
      without the prior written consent of Sublessor (and the consent of Lessor,
      if
      such is required under the terms of the Master Lease),
      which
      consent from Sublessor shall not be unreasonably withheld, conditioned or
      delayed.

    

    In
      no
      event shall the public sale of stock in Sublessee or its parent or subsidiaries
      be deemed to constitute a transfer of this Lease.  

    

    
      
        
        

      

      
        2

        
          

        

      

      
        
        

      

    

    
      	
              10.

            	
              OTHER
                PROVISIONS OF SUBLEASE. 

            

    

    

    Except
      to
      the extent expressly provided for in this Sublease (and any Amendments) to
      the
      contrary (e.g., Term, Commencement Date, size of Premises, Rent, etc.) and
      only
      to the extent that such terms and conditions reasonably apply to the Sublessee
      and the Premises, all
      applicable terms and conditions of the Master Lease are incorporated into and
      made a part of this Sublease as if Sublessor were the lessor thereunder,
      Sublessee the lessee thereunder, and the Premises the Master
      Premises.

    Sublessee
      assumes and agrees to perform the lessee's obligations under the Master Lease
      during the Term to the extent that such obligations are applicable to the
      Premises, except that the obligation to pay rent to Lessor under the Master
      Lease shall
      be
      considered performed by Sublessee to the extent and in the amount rent is paid
      to Sublessor in accordance with Section 6 of this Sublease. Sublessee shall
      not
      commit or suffer any act or omission that will violate any of the provisions
      of
      the Master Lease. Sublessor shall exercise due diligence in attempting to cause
      Lessor to perform its obligations under the Master
      Lease for the benefit of Sublessee. If the Master Lease terminates,
      this
      Sublease shall terminate and the parties shall be relieved of any further
      liability or obligation under this Sublease, provided however, that if the
      Master Lease terminates as
      a
      result of a default or breach by Sublessor or Sublessee under this Sublease
      and/or the Master Lease, then the defaulting party shall be liable to the
      nondefaulting party for the damage suffered as a result of such termination.
      Notwithstanding the foregoing, if the Master Lease gives Sublessor the
      right to
      terminate the Master Lease
      in the
      event of the partial or total damage, destruction, or condemnation of the Master
      Premises or the building or project of which the Master Premises are a part,
      the
      exercise of such right by Sublessor shall not constitute a default or breach
      hereunder. THE PARTIES AGREE THAT IN
      NO
      EVENT SHALL EITHER PARTY BE LIABLE UNDER THIS AGREEMENT FOR ANY SPECIAL,
      EXEMPLARY, PUNITIVE, INDIRECT OR CONSEQUENTIAL DAMAGES (INCLUDING ANY LOST
      PROFIT, REVENUE, BUSINESS OR OTHERWISE); REGARDLESS OF THE THEORY OF RECOVERY,
      WHETHER ALLEGED AS A BREACH OF CONTRACT, TORT (INCLUDING NEGLIGENCE AND STRICT
      LIABILITY), UNJUST ENRICHMENT OR OTHERWISE, EVEN IF SUCH PARTY HAS BEEN ADVISED
      OF THE POSSIBILITY OF SUCH DAMAGES OR BASED ON THE FAILURE OF THE ESSENTIAL
      PURPOSE OF ANY REMEDY.

    

    
      	
              11.

            	
              ATTORNEYS’
                FEES. 

            

    

    

    If
      Sublessor, Sublessee, or Broker shall commence an action against the other
      arising out of or in connection with this Sublease, the prevailing party shall
      be entitled to recover its costs of suit and reasonable attorney's
      fees.

    

    
      	
              12.

            	
              AGENCY
                DISCLOSURE:

            

    

    

    Sublessor
      and Sublessee each warrant that they have dealt with no other real estate broker
      in connection with this transaction except: CB RICHARD ELLIS, INC., who
      represents Sublessee,
      and CB
      RICHARD ELLIS, INC. who
      represents Sublessor.
      In the
      event CB RICHARD ELLIS, INC., represents both Sublessor and Sublessee, Sublessor
      and Sublessee hereby confirm that they were timely advised of the dual
      representation and that they consent to the same, and that they do
      not
      expect said broker to disclose to either of them the confidential information
      of
      the other party. 

    

    
      	
              13.

            	
              COMMISSION:

            

    

    

    Per
      a
      separate agreement.

    

    
      	14.	
              NOTICES: 

            

    

    

    All
      notices and demands which may or are to be required or permitted to be given
      by
      either party on the other hereunder shall be In writing. All notices and demands
      by the Sublessor to Sublessee shall be sent by United States Mail, postage
      prepaid, or
      by a
      nationally recognized overnight courier service (e.g., FedEx), addressed
      to the Sublessee at the Premises, and to the address herein below, or to such
      other place as Sublessee may from time to time designate in a notice to the
      Sublessor. All notices and demands by the Sublessee to Sublessor shall be sent
      by United States Mail, postage prepaid, or by a nationally recognized overnight
      courier service (e.g., FedEx), addressed to the Sublessor at the address set
      forth herein, and to such other person or place as the Sublessor may from time
      to time designate in a notice to the Sublessee.

    
      
        
        

      

      
        3

        
          

        

      

      
        
        

      

    

    

    To
      Sublessor: MJ Research Company, Inc., 1000 Alfred Nobel Drive, Hercules,
      California 94547, Attention, Office of the General Counsel / copy to Director
      of
      Real Estate

    

    To
      Sublessee: 

    Copies
      of
      all notices to Sublessee should be directed to Hana Biosciences, Inc. at 7000
      Shoreline Court, South San Francisco, CA 94080, attention John Iparraguirre.
      

    

    
      	
              15.

            	
              CONSENT
                BY LESSOR.

            

    

    

    THIS
      SUBLEASE SHALL BE OF NO FORCE OR EFFECT UNLESS CONSENTED TO BY LESSOR WITHIN
      10
      DAYS AFTER EXECUTION HEREOF, IF SUCH CONSENT IS REQUIRED UNDER THE TERMS OF
      THE
      MASTER LEASE.

    

    
      	
              16.

            	
              COMPLIANCE.

            

    

    

    The
      parties hereto agree to comply with all applicable federal, state and local
      laws, regulations, codes, ordinances and administrative orders having
      jurisdiction over the parties, property or the subject matter of this Agreement,
      including, but not limited to, the 1964 Civil Rights Act and all amendments
      thereto, the Foreign Investment In Real Property Tax Act, the Comprehensive
      Environmental Response Compensation and Liability Act, and The Americans With
      Disabilities Act.

    

    

    
      	
              Sublessor:
                MJ Research Company, Inc.

            	
              Sublessee:
                Hana Biosciences, Inc.

            
	 	 
	
              By:
                /s/
                Walker                                                              
                

            	
              By:
                /s/ John P. Iparraguirre

            
	 	 
	
              Title:
                Vice
                President                                                    
                

            	
              Title:
                

            
	 	 
	
               

            	
              By:
                

            
	 	 
	
               

            	
              Title:
                

            
	 	 
	
              Date:
                6/7/06                                                                  
                

            	
              Date:
                

            

    

    

    

    

    
      
        
        

      

      
        4

        
          

        

      

      
        
        

      

    

    Amendment
      to Sublease Agreement

    

    This
      is
      an Amendment to the Sublease Agreement (“Sublease”) dated May 31st,
      2006
      between MJ Research Company, Inc. (“Sublessor”) and Hana Biosciences, Inc.
      (“Sublessee”) for the real property described as that portion of 7000 Shoreline
      Court, South San Francisco, California described in further detail in the
      Sublease (“Premises”).

    

    Sublessor
      and Sublessee hereby agree to amend the Sublease as follows:

    

    1.  FULL
      SERVICE SUBLEASE
      Property
      tax, insurance, common area maintenance (CAM’s) and utilities are included
      within the Rent set forth in Section 6 of the Sublease. Sublease shall only
      be
      responsible for its Pro-Rata Share (as defined below) of Sublessor’s operating
      expense (that is, the foregoing expenses as well as other “Operating Expenses”
as defined in the Master Lease) increases above a 2006 base year. Sublessee’s
      Pro-Rata Share is a fraction, the numerator of which is the rentable area of
      the
      Premises (averaged for that Lease Year), which is currently 28,820 square feet.
      Such additional rent shall be payable as and when such operating expenses are
      payable by Sublessor; provided, however, that Sublessor shall be obligated
      to
      provided, fifteenth (15) days prior notice of its due date.

    

    2.  CONFIRMATION
      OF TERMINATION DATE
      Sublessee shall have a one-time right to confirm the Termination Date as set
      forth in Section 5 of the Sublease. Said right shall be exercisable at any
      time
      on or before the end of the twenty forth (24th)
      month
      of the Term. In the event Sublessee exercises said confirmation of the
      Termination Date, the sublease term shall terminate on May 31, 2009. If
      Sublessee doe not exercise its confirmation of the Termination Date, Sublessee
      shall have no further right to terminate and the Sublease Term shall be extended
      for the remainder of the Master Lease term. Said Term shall be an additional
      twenty two (22) months, terminating March 31, 2011. The rental rate for the
      additional term shall be:

     

    
      
        	
                Months

              	
                RSF/Month/Full
                  Service

              
	
                37-48:

              	
                $2.80
                  Fully Serviced

              
	
                49-58:

              	
                $2.90
                  Fully Serviced

              

      

    3.  CONDITION
      OF PREMISES

    Sublessor
      shall deliver the Premises in its existing condition.

    

    4.  OFFICE
      FURNISHINGS Sublessee,
      at no additional cost, shall have the use for the Term but not the ownership
      of
      any currently in-place office furnishings excluding the desk/task chairs.
      Sublessor makes no representations or warranties on the condition of such
      furnishings and Sublessee hereby accepts said furnishings in as-is
      condition.

    

    5.  DEMISING
      OF THE PREMISES
      Sublessor’s obligations pursuant to this paragraph are subject to and contingent
      upon the cost feasibility (in Sublessor’s sole discretion) of the demising of
      the Premises. Sublessor shall not be obligated to demise (separate by wall,
      etc.) the Premises from the remainder of the Master Premises unless and until
      the remained of the Master Premises on the third floor is subleased to another
      tenant(s). Demising, if required, shall be at the sole cost and responsibility
      of the Sublessor and completed per governmental codes. A proposed demising
      plan
      shall be attached to the Sublease upon completion of such plan and Sublease
      agrees to accept said plan and any modifications of its Premises required to
      provide exits and corridors per governmental codes.

    

    Notwithstanding
      the foregoing, if Sublessor elects not to erect such demising walls, Sublessee’s
      square footage shall not be modified from that defined in the Sublease. If
      Sublessor elects to erect such demising walls, (i) such walls shall be erected
      in a good and workmanlike manner, (ii) done in such a manner as to reduce any
      unreasonable interference to Sublessee’s business, (ii) they shall be erected,
      taped, sanded and painted to match the adjacent walls within Sublessee’s
      Premises, (iv) if there is any reduction in the size of the Premises, then
      Sublessee’s pro rata share will be reduced accordingly (however, Sublessee’s pro
      rata portion of common area will increase commensurately) or (v) if there is
      an
      increase in the size of the Premises, Sublessee’s Pro-Rata Share will not be
      adjusted upward.

    

    Amendment
      to Sublease Agreement

    

    6.  BUILDING
      EXERCISE FACILITY
      Sublessee will pay Lessor directly for the use of the exercise facility. The
      exercise facility cost is $5.00 per participating employee per month (or such
      other amount as may be imposed by Lessor). The parties agree that Sublessor
      shall not be responsible for any such payments.

    

    7.  SIGNAGE: Sublessee
      shall have signage rights provided to Sublessor as provided for under the Master
      Lease.

    

    Except
      as
      expressly set forth in this Amendment, the Sublease shall remain in full force
      and effect.

    

    

      
        	
                Sublessor:    MJ
                  Research Company, Inc.

              	 	
                Sublessee:    Hana
                  Biosciences

              
	 	 	 
	
                By:
                  /s/ L. Walker

              	 	
                By:
                  /s/ John P. Iparraguirre

              
	 	 	 
	
                Title:    Vice
                  President

              	 	
                Title:
                  

              
	 	 	 
	 	 	
                By:
                  

              
	 	 	 
	 	 	
                Title:
                  

              
	 	 	 
	
                Address:     
590
                  Lincoln St

              	 	
                Address:
                  

              
	
                         
Waltham
                  MA
                  02451

              	 	 
	
                 

              	 	
                 

              
	 	 	 
	
                Telephone:

              	 	
                Telephone:Exhibit
      10.16

    HANA
      BIOSCIENCES, INC.

    Amendment
      to Stock Option Agreements

    

     

    This
      Amendment to Stock Option Agreements (this “Amendment”)
      is
      made and entered into as of the 30th day of June, 2006, between Mark J. Ahn
      (“Optionee”)
      and
      Hana Biosciences, Inc., a Delaware corporation (the “Company”).

     

    Background

     

    A.       Optionee
      and the Company entered into several Stock Option Agreements dated as of
      November 1, 2003, February 15, 2004, February 26, 2004, and July 20, 2004,
      respectively (individually a “Stock
      Option Agreement”
and
      collectively the “Stock
      Option Agreements”).

     

    B.       
      Pursuant to the Stock Option Agreements, the Company granted Optionee options
      to
      purchase an aggregate of 952,305 shares of the Company’s common stock, as
      adjusted to reflect stock splits, combinations, mergers and other adjustments
      prior to the date hereof.

     

    C.       The
      applicable exercise price relating to each Stock Option Agreement was less
      than
      the fair market value of the Company’s common stock on the respective dates of
      the Stock Option Agreements.

     

    D.       On
      May 9, 2006, Optionee exercised his option to purchase shares of Company common
      stock under the November 1, 2003 Stock Option Agreement in the amount of 164,508
      shares, leaving a total of 787,797 shares available for exercise under the
      Stock
      Option Agreements.

     

    E.       Due
      to the tax implications of Section 409A of the Internal Revenue Code of 1986,
      as
      amended, the Company and Optionee have agreed to amend the Stock Option
      Agreements in order to increase the exercise prices to equal the fair market
      value of the Company’s common stock as of the date of each such agreement.

     

    F.       
      To compensate the Optionee for increasing the exercise prices, the Company
      has
      issued to Optionee 74,887 shares of restricted common stock, subject to the
      terms set forth in that certain Restricted Stock Agreement by and between the
      Company and Optionee dated of even date herewith.

     

    G.       Optionee
      and the Company hereby agree to amend the terms of the respective Stock Option
      Agreements to reflect the adjustment to the exercise price as set forth
      below.

     

    Agreement

     

    Now,
      Therefore,
      the
      parties hereto agree as follows:

     

    I.       Adjustment
      to Exercise Prices.
      Notwithstanding anything to the contrary contained in the Stock Option
      Agreements, the exercise price set forth in each Stock Option Agreement shall
      be
      amended as follows:

     

    
      	
              Date
                of Stock Option Agreement

            	 	
              Original
                Exercise Price

            	 	
              Amended
                Price

            
	 	 	 	 	 
	
              November
                1, 2003

            	 	
              $0.167

            	 	
              $0.833

            
	 	 	 	 	 
	
              February
                15, 2004

            	 	
              $0.167

            	 	
              $0.833

            
	 	 	 	 	 
	
              February
                26, 2004

            	 	
              $0.337

            	 	
              $1.684

            
	 	 	 	 	 
	
              July
                20, 2004

            	 	
              $0.337

            	 	
              $1.684

            

    

     

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    II.       General.
      

     

    A.       Except
      as specifically amended by this Amendment, the terms of the respective Stock
      Option Agreements shall continue in full force and effect without
      amendment.

     

    B.       Nothing
      herein expressed or implied is intended or shall be construed as conferring
      upon
      or giving to any person, firm, or corporation other than the parties hereto,
      any
      rights or benefits under or by reason of this Amendment.

     

    C.       Each
      party hereto agrees to execute such further documents as may be necessary or
      desirable to effect the purposes of this Amendment.

     

    D.       This
      Amendment may be executed in any number of counterparts, each of which shall
      be
      deemed an original, but all of which shall constitute one and the same
      agreement.

     

    E.       This
      Amendment, together with the Stock Option Agreements, embodies the entire
      agreement made between the parties hereto with respect to matters covered herein
      and shall not be modified except in a writing signed by each of the parties
      hereto.

    

    

    IN
      WITNESS WHEREOF, the undersigned have executed this Amendment to Stock Option
      Agreements as of the date first written above.

     

    

    
      	 	
              OPTIONEE

               

              /s/
                Mark J. Ahn

              Name:
                Mark J. Ahn

            
	 	
               

               

              HANA
                BIOSCIENCES, INC.

               

              By:
                /s/ John P. Iparraguirre

              John
                P. Iparraguirre

              Vice
                President, Chief Financial Officer

            
	 	 

    

    

    

    

    
      
         

      

      
        2

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