Document:

AMENDMENT
TO SECURITIES PURCHASE AGREEMENT

 

This
AMENDMENT TO SECURITIES PURCHASE AGREEMENT (this “Amendment”), dated as of February __, 2018, is by and among
Hancock Jaffe Laboratories, Inc., a Delaware corporation (the “Company”), and the undersigned signatories hereto
(collectively, the “Lenders”), and amends that certain Securities Purchase Agreement, dated as of January 5,
2018, by and among the Company and the signatories thereto (the “Purchasers” and altogether, the “Purchase
Agreement”), the Convertible Notes issued pursuant to the Purchase Agreement (the “2018 Notes”),
and the Common Stock Purchase Warrants issued pursuant to the Purchase Agreement (the “2018 Warrants” and,
together with the Purchase Agreement and the 2018 Notes, the “Transaction Documents”). Capitalized terms used
but not defined herein shall have the meaning ascribed to such terms in the Transaction Documents.

 

RECITALS

 

WHEREAS,
the Company and the Lenders desire to amend the Transaction Documents to (i) extend the maturity date of the 2018 Notes to May
15, 2018, and (ii) provide that the number of Warrant Shares exercisable under the 2018 Warrants shall equal 75% of the number
of shares of Common Stock issuable upon conversion of the 2018 Notes;

 

WHEREAS,
pursuant to Section 5.4 of the Purchase Agreement, the Transaction Documents may be amended or the respective terms waived with
the written consent of the Company and the Purchasers holding a majority of the aggregate principal amount of all 2018 Notes issued
under the Purchase Agreement (the “Requisite Holders”); and

 

WHEREAS,
the Company and the undersigned Lenders, constituting the Requisite Holders, desire to amend the Transaction Documents as hereinafter
set forth.

 

AGREEMENT

 

NOW,
THEREFORE, for good and valuable consideration the receipt and sufficiency of which are hereby acknowledged and agreed, the parties
hereby agree as follows:

 

1.
Amendment to Purchase Agreement Section 2.2(a)(iii). Section 2.2(a)(iii) of the Purchase Agreement is hereby amended
and restated in its entirety as follows:

 

“(iii)
a Warrant registered in the name of such Purchaser with an exercise price per share equal to the lesser of (a) $14.40 or (b) 120%
of the Conversion Price, and to purchase up to a number of shares of Common Stock equal to 75% of the number of shares of Common
Stock issuable upon conversion of such Purchaser’s Note.”

 

2.
Amended and Restated Note. In connection and to facilitate the stated intent of the Company and the Lenders in the
recitals, among other things, the parties consent and agree that the 2018 Notes issued to all Purchasers are hereby amended and
restated, substantially in the form attached hereto as Exhibit A (the “Amended and Restated Note”).
The Company shall execute and deliver the Amended and Restated Note to each Purchaser.

 

    	 

    	 

    

 

3.
Amended and Restated Warrant. In connection and to facilitate the stated intent of the Company and the Lenders in the
recitals, among other things, the parties consent and agree that the 2018 Warrants issued to all Purchasers are hereby amended
and restated substantially in the form attached hereto as Exhibit B (the “Amended and Restated Warrant”).
The Company shall execute and deliver the Amended and Restated Warrant to each Purchaser.

 

4.
No Other Amendments. Except as herein amended, all provisions of the Transaction Documents shall remain in full force
and effect.

 

5.
Governing Law. This Amendment shall be governed by and construed in accordance with the internal laws of the State
of Delaware without giving effect to any choice or conflict of law provision or rule (whether of the State of Delaware or any
other jurisdiction) that would cause the application of laws of any jurisdiction other than those of the State of Delaware.

 

6.
Enforceability. If any provision of this Amendment is held invalid or unenforceable by any court of competent jurisdiction,
the other provisions of this Amendment will remain in full force and effect. Any provision of this Amendment held invalid or unenforceable
only in part or degree will remain in full force and effect to the extent not held invalid or unenforceable.

 

7.
Counterparts. This Amendment may be executed in one or more counterparts, each of which shall have the same force and
effect of the original.

 

[Signature
Page Follows]

 

    	 

    	 

    

 

IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the date first above written.

 

	 	COMPANY:
	 	 
	 	HANCOCK
    JAFFE LABORATORIES, INC.
	 	 	 
	 	By:	 
	 	Name:	William
R. Abbott
	 	Title:
    	Chief
    Financial Officer

 

Signature
Page to Amendment to Securities Purchase Agreement

 

    	 

    	 

    

 

IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the date first above written.

 

	 	LENDER:
	 	 	 
	 	By:	 
	 	Name:
    	 
	 	Title:
    	 

 

Signature
Page to Amendment to Securities Purchase Agreement

 

    	 

    	 

    

 

EXHIBIT
A

 

Amended
and Restated Note

 

    	 

    	 

    

 

EXHIBIT
B

 

Amended
and Restated WarrantNEITHER
THIS SECURITY NOR THE SECURITIES INTO WHICH THIS SECURITY IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE
COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”) AND APPLICABLE STATE SECURITIES LAWS, AND, ACCORDINGLY, MAY NOT
BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE
EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF CORPORATE COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE
OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY.

 

Original
Issue Date: January __, 2018

Amended
and Restated: February __, 2018

 

$[*]

 

AMENDED
AND RESTATED CONVERTIBLE NOTE 

 

THIS
AMENDED AND RESTATED CONVERTIBLE NOTE is one of a series of duly authorized and validly issued Convertible Notes of Hancock Jaffe
Laboratories, Inc., a Delaware corporation (the “Company”), having its principal place of business at 70 Doppler
Irvine, California, 92618 (this Note, the “Note” and, collectively with the other Notes of such series, the
“Notes”).

 

FOR
VALUE RECEIVED, the Company promises to pay to [*] or its registered assigns (the “Holder”), or shall
have paid pursuant to the terms hereunder, the principal sum of $[*] together with interest thereon on May 15, 2018 (the “Maturity
Date”) or such earlier date as this Note is required or permitted to be repaid as provided hereunder. This Note shall
bear interest in accordance with Section 2. This Note is subject to the following additional provisions:

 

Section
1. Definitions. For the purposes hereof, in addition to the terms defined elsewhere in this Note, (a) capitalized terms
not otherwise defined herein shall have the meanings set forth in the Purchase Agreement and (b) the following terms shall have
the following meanings:

 

“Bankruptcy
Event” means any of the following events: (a) the Company or any Significant Subsidiary (as such term is defined in
Rule 1-02(w) of Regulation S-X) thereof commences a case or other proceeding under any bankruptcy, reorganization, arrangement,
adjustment of debt, relief of debtors, dissolution, insolvency or liquidation or similar law of any jurisdiction relating to the
Company or any Significant Subsidiary thereof, (b) there is commenced against the Company or any Significant Subsidiary thereof
any such case or proceeding that is not dismissed within 60 days after commencement, (c) the Company or any Significant Subsidiary
thereof is adjudicated insolvent or bankrupt or any order of relief or other order approving any such case or proceeding is entered,
(d) the Company or any Significant Subsidiary thereof suffers any appointment of any custodian or the like for it or any substantial
part of its property that is not discharged or stayed within 60 calendar days after such appointment, (e) the Company or any Significant
Subsidiary thereof makes a general assignment for the benefit of creditors, (f) the Company or any Significant Subsidiary thereof
calls a meeting of its creditors with a view to arranging a composition, adjustment or restructuring of its debts or (g) the Company
or any Significant Subsidiary thereof, by any act or failure to act, expressly indicates its consent to, approval of or acquiescence
in any of the foregoing or takes any limited liability company or other action for the purpose of effecting any of the foregoing.

 

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“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or
any day on which banking institutions in the State of New York are authorized or required by law or other governmental action
to close.

 

“Buy-In”
shall have the meaning set forth in Section 4(d)(vi).

 

“Common
Stock” means shares of the Company’s common stock, par value $0.00001 per share, and any other class of
securities into which such securities may hereafter be reclassified or changed.

 

“Conversion”
shall have the meaning ascribed to such term in Section 4.

 

“Conversion
Date” shall have the meaning set forth in Section 4(a).

 

“Conversion
Price” shall have the meaning set forth in Section 4(b).

 

“Conversion
Shares” means, collectively, the shares of Common Stock issuable upon conversion of this Note in accordance with the
terms hereof.

 

“Event
of Default” shall have the meaning set forth in Section 6(a).

 

“New
York Courts” shall have the meaning set forth in Section 7(d).

 

“Note
Register” shall have the meaning set forth in Section 2.

 

“Notice
of Conversion” shall have the meaning set forth in Section 4(a).

 

“Original
Issue Date” means the date of the first issuance of the Notes, regardless of any transfers of any Note and regardless
of the number of instruments which may be issued to evidence such Notes.

 

“Purchase
Agreement” means the Securities Purchase Agreement, dated as of January 5, 2018, by and among the Company and the Holders
signatory thereto, as amended, modified or supplemented from time to time in accordance with its terms.

 

“Securities
Act” shall have the meaning set forth in the preamble legend to this Note.

 

“Share
Delivery Date” means, subject to Sections 4(d)(i) and (ii), five (5) Business Days after the applicable
Conversion Date.

 

“Trading
Day” means a day on which the principal Trading Market is open for trading.

 

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“Trading
Market” means any of the following markets or exchanges on which the Common Stock (or an equivalent thereof) is listed
or quoted for trading on the date in question: the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq
Global Select Market, the New York Stock Exchange, the OTC Bulletin Board or the Pink OTC Markets (or any successors to any of
the foregoing).

 

Section
2. Interest; Prepayment. The Company acknowledges and agrees that this Note shall bear interest at a rate of fifteen percent
(15%) per annum, to be paid quarterly in cash on the last Trading Day of each fiscal quarter. Regularly scheduled interest payments
shall be made on this Note. All payments hereunder will be paid to the Person in whose name this Note is registered on the records
of the Company regarding registration and transfers of this Note (the “Note Register”). At the discretion of
the Company, the Principal Amount and unpaid accrued interest of this Note may be prepaid at anytime, provided that written notice
is provided to the Holder at least fifteen (15) days in advance of the prepayment.

 

Section
3. Registration of Transfers and Exchanges.

 

a)
Different Denominations. This Note is exchangeable for an equal aggregate principal amount of Notes of different authorized
denominations, as requested by the Holder surrendering the same; provided, that the minimum principal amount of any replacement
Note shall be $50,000.00. No service charge will be payable for such registration of transfer or exchange.

 

b)
Investment Representations. This Note has been issued subject to certain investment representations of the original Holder
set forth in the Purchase Agreement and may be transferred or exchanged only in compliance with the Purchase Agreement and applicable
federal and state securities laws and regulations to successor Holders who provide the same investment representations to the
Company.

 

c)
Reliance on Note Register. Prior to due presentment for transfer to the Company of this Note, the Company and any agent
of the Company may treat the Person in whose name this Note is duly registered on the Note Register as the owner hereof for the
purpose of receiving payment as herein provided and for all other purposes, whether or not this Note is overdue, and neither the
Company nor any such agent shall be affected by notice to the contrary.

 

Section
4. Conversion.

 

a)
Voluntary and Mandatory Conversion.

 

i.
At any time after the Original Issue Date until the Maturity Date, the outstanding principal amount of this Note, plus all accrued
but unpaid interest (the “Accreted Value”) shall be convertible, in whole or in part, into shares of Common
Stock at the option of the Holder, at any time and from time to time, at the Conversion Price specified in Section 3(b)(i)
below and in the manner specified in Section 3(d)(ii) below. The Holder shall effect any conversion pursuant to this
Section 4(a)(i) by delivering to the Company a Notice of Conversion, the form of which is attached hereto as Annex A
(each, a “Notice of Conversion”), specifying therein, among other things, the date on which such conversion
shall be effected (such date, the “Voluntary Conversion Date”). If no Conversion Date is specified in a Notice
of Conversion, the Conversion Date shall be the date that such Notice of Conversion is deemed delivered hereunder. To effect conversions
hereunder, the Holder shall be required to physically surrender this Note to the Company. The Company may deliver an objection
to any Notice of Conversion within two (2) Business Days of delivery of such Notice of Conversion.

 

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ii.
If on or prior to the Maturity Date, the Company consummates its initial public offering of its Common Stock pursuant to the Securities
Act (the “IPO”), the entire Accreted Value of this Note shall be converted into shares of Common Stock at the
Conversion Price specified in Section 3(b)(ii) below and in the manner specified in Section 3(d)(iii) below.

 

b)
Conversion Price.

 

i.
The Conversion Price in effect on a Voluntary Conversion Date in connection with a voluntary conversion pursuant to Section
4(a)(i) shall be $12.00.

 

ii.
The Conversion Price in effect on an IPO Conversion Date (as defined below) in connection with a mandatory conversion pursuant
to Section 4(a)(ii) shall be the lesser of (A) $12.00 or (B) the product equal to the price per share of Common Stock sold
in the Company’s IPO, multiplied by 70%.

 

c)
Adjustments to Conversion Price.

 

i.
In the event the Company (i) makes a distribution or distributions on shares of Common Stock payable in Common Stock (which, for
avoidance of doubt, shall not include any Common Stock issued by the Company upon conversion of, or payment of interest on, the
Notes), (ii) subdivides outstanding Common Stock into a larger number of Common Stock, (iii) combines (including by way of a reverse
split) outstanding Common Stock into a smaller number of Common Stock or (iv) issues, in the event of a reclassification of Common
Stock, any Common Stock of the Company, then the Conversion Price shall be adjusted by multiplying the Conversion Price by a fraction
of which the numerator shall be the number of shares of Common Stock outstanding immediately before such event, and of which the
denominator shall be the number of shares of Common Stock outstanding immediately after such event. Any adjustment made pursuant
to this Section shall become effective immediately after the record date for the determination of members entitled to receive
such distribution and shall become effective immediately after the effective date in the case of a subdivision, combination or
re-classification.

 

ii.
If at any time or from time to time after the issuance date of this Note there shall be a capital reorganization of the Company
(other than by way of a stock split or combination of shares or stock dividends or distributions, or a reclassification, exchange
or substitution of shares), or a merger or consolidation of the Company with or into another corporation where the holders of
the Company’s outstanding voting securities prior to such merger or consolidation do not own over fifty percent (50%) of
the outstanding voting securities of the merged or consolidated entity, immediately after such merger or consolidation, or the
sale of all or substantially all of the Company’s properties or assets to any other person (an “Organic Change”),
then as a part of such Organic Change an appropriate revision to the conversion price shall be made if necessary and provision
shall be made if necessary (by adjustments of the conversion price or otherwise) so that, upon any subsequent conversion of this
Note, the Holder shall have the right to receive, in lieu of Conversion Shares, the kind and amount of shares of stock and other
securities or property of the Company or any successor corporation resulting from the Organic Change. In any such case, appropriate
adjustment shall be made in the application of the provisions of Section 4(a) with respect to the rights of the Holder
after the Organic Change to the end that the provisions of Section 4(a) (including any adjustment
in the conversion price then in effect and the number of shares of stock or other securities deliverable upon conversion of this
Note) shall be applied after that event in as nearly an equivalent manner as may be practicable.

 

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d)
Mechanics of Conversion.

 

i.
Conversion Shares Issuable Upon Conversion of Principal Amount. The number of Conversion Shares issuable upon a conversion
hereunder shall be determined by the quotient obtained by dividing (x) the Accreted Value by (y) the Conversion Price.

 

ii.
Mechanics of Voluntary Conversion. In connection with a conversion by the Company pursuant to Section 4(a)(i), the
Company shall provide Holder the Notice of Conversion in accordance with Section 4(a)(i). Upon receipt of the notice from
the Company, this Note shall automatically, and without any further action on the part of the Holder and whether or not the Note
is surrendered to the Company, be converted into shares of Common Stock at the Conversion Price specified in Section 4(b)(i)
above. The Company shall not be obligated to issue certificates evidencing the shares of Common Stock issuable upon such conversion
unless this Note is either delivered to the Company or the Holder notifies the Company that this Note been lost, stolen or destroyed
and executes an agreement satisfactory to the Company to indemnify the Company from any loss incurred by it in connection with
such loss, theft or destruction. Upon receipt by the Company of this Note or an agreement satisfactory to the Company to indemnify
the Company from any loss incurred by it in connection with such loss, theft or destruction, the Company at its expense shall,
as soon as practicable thereafter, issue and deliver at such office to such Holder, or to the nominee or nominees of such Holder,
a certificate or certificates for the shares of Common Stock to which such Holder shall be entitled as aforesaid. Such conversion
shall be deemed to have been upon the date specified in the Notice of Conversion, and the person or persons entitled to receive
the shares of Common Stock issuable upon such conversion shall be treated for all purposes as the record holder or holders of
such Common Stock as of such date. Notwithstanding the foregoing, if the Company’s transfer agent is participating in the
DTC Fast Automated Securities Transfer Program, the Company may credit such aggregate number of shares of Common Stock to which
the Holder shall be entitled pursuant to such conversion to the Holder’s or its designee’s balance account with DTC
through its Deposit/Withdrawal at custodian system.

 

ii.
Mechanics of Mandatory Conversion. Upon a mandatory conversion pursuant to Section 4(a)(ii), the Accreted Value
shall automatically, and without any further action on the part of the Holder and whether or not the Note is surrendered to the
Company, be converted into shares of Common Stock at the Conversion Price specified in Section 4(b)(ii) above on the consummation
of the IPO (the “IPO Conversion Date” and together with the Voluntary Conversion Date, the “Conversion
Date”). The Company shall not be obligated to issue certificates evidencing the shares of Common Stock issuable upon
such mandatory conversion unless this Note is either delivered to the Company or the Holder notifies the Company that this Note
been lost, stolen or destroyed and executes an agreement satisfactory to the Company to indemnify the Company from any loss incurred
by it in connection with such loss, theft or destruction. Upon receipt by the Company of this Note or an agreement satisfactory
to the Company to indemnify the Company from any loss incurred by it in connection with such loss, theft or destruction, the Company
at its expense shall, as soon as practicable thereafter, issue and deliver at such office to such Holder, or to the nominee or
nominees of such Holder, a certificate or certificates for the shares of Common Stock to which such Holder shall be entitled as
aforesaid. Such conversion shall be deemed to have been upon the completion of the IPO, and the person or persons entitled to
receive the shares of Common Stock issuable upon such conversion shall be treated for all purposes as the record holder or holders
of such shares of Common Stock as of such date. Notwithstanding the foregoing, if the Company’s transfer agent is participating
in the DTC Fast Automated Securities Transfer Program, the Company may credit such aggregate number of shares of Common Stock
to which the Holder shall be entitled pursuant to such conversion to the Holder’s or its designee’s balance account
with DTC through its Deposit/Withdrawal at custodian system.

 

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iv.
Failure to Deliver Certificates. Except in the case of a mandatory conversion in connection with Section 4(a)(ii),
in the case a Notice of Conversion is issued by the Holder to the Company, and such certificate or certificates are not delivered
to or as directed by the applicable Holder by the Share Delivery Date, the Holder shall be entitled to elect by written notice
to the Company at any time on or before its receipt of such certificate or certificates, to rescind such Conversion, in which
event the Company shall promptly return to the Holder any original Note delivered to the Company and the Holder shall promptly
return to the Company the Common Stock certificates issued to such Holder pursuant to the rescinded Notice of Conversion.

 

v.
Obligation Absolute; Partial Liquidated Damages. The Company’s obligations to issue the Conversion Shares upon conversion
of this Note in accordance with the terms hereof are absolute and unconditional, irrespective of any action or inaction by the
Holder to enforce the same, any waiver or consent with respect to any provision hereof, the recovery of any judgment against any
Person or any action to enforce the same, or any setoff, counterclaim, recoupment, limitation or termination, or any breach or
alleged breach by the Holder or any other Person of any obligation to the Company or any violation or alleged violation of law
by the Holder or any other Person, and irrespective of any other circumstance which might otherwise limit such obligation of the
Company to the Holder in connection with the issuance of such Conversion Shares; provided, however, that such delivery
shall not operate as a waiver by the Company of any such action the Company may have against the Holder. Nothing herein shall
limit a Holder’s right to pursue actual damages or declare an Event of Default (as defined below) pursuant to Section
6 hereof for the Company’s failure to deliver Conversion Shares within the period specified herein and the Holder shall
have the right to pursue all remedies available to it hereunder, at law or in equity including, without limitation, a decree of
specific performance and/or injunctive relief. The exercise of any such rights shall not prohibit the Holder from seeking to enforce
damages pursuant to any other Section hereof or under applicable law.

 

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vi.
Compensation for Buy-In on Failure to Timely Deliver Certificates Upon Conversion at IPO. Subject to Sections 4(d)(i)
and (ii), in addition to any other rights available to the Holder, if the Company fails for any reason to deliver to
the Holder such certificate or certificates by the Share Delivery Date pursuant to Sections 4(d)(i) and (ii), and
if after such Share Delivery Date the Holder is required by its brokerage firm to purchase (in an open market transaction or otherwise),
or the Holder’s brokerage firm otherwise purchases, shares of Common Stock, to deliver in satisfaction of a sale by the
Holder of the Conversion Shares which the Holder was entitled to receive upon the conversion relating to such Share Delivery Date
(a “Buy-In”), then the Company shall (A) pay in cash to the Holder (in addition to any other remedies available
to or elected by the Holder) the amount, if any, by which (x) the Holder’s total purchase price (including any brokerage
commissions) for the shares of Common Stock so purchased exceeds (y) the product of (1) the aggregate number of shares of Common
Stock that the Holder was entitled to receive from the conversion at issue multiplied by (2) the actual sale price at which the
sell order giving rise to such purchase obligation was executed (including any brokerage commissions) and (B) at the option of
the Holder, either reissue (if surrendered) this Note in a principal amount equal to the principal amount of the attempted conversion
(in which case such conversion shall be deemed rescinded) or deliver to the Holder the number of shares of Common Stock that would
have been issued if the Company had timely complied with its delivery requirements under Sections 4(d)(i) and (ii).
For example, if the Holder purchases shares of Common Stock having a total purchase price of $11,000 to cover a Buy-In with respect
to an attempted conversion of this Note with respect to which the actual sale price of the Conversion Shares (including any brokerage
commissions) giving rise to such purchase obligation was a total of $10,000 under clause of the immediately preceding sentence,
the Company shall be required to pay the Holder $1,000. The Holder shall provide the Company written notice indicating the amounts
payable to the Holder in respect of the Buy-In and, upon request of the Company, evidence of the amount of such loss. Nothing
herein shall limit a Holder’s right to pursue any other remedies available to it hereunder, at law or in equity including,
without limitation, a decree of specific performance and/or injunctive relief with respect to the Company’s failure to timely
deliver certificates representing shares of Common Stock upon conversion of this Note as required pursuant to the terms hereof.

 

vii.
Fractional Common Shares. No fractional shares of Common Stock shall be issued upon the conversion of this Note. As to
any fraction of a share which the Holder would otherwise be entitled to purchase upon such conversion, the Company shall at its
election, either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the
Conversion Price or round up to the next whole share of Common Stock.

 

Section
5. Negative Covenants.

 

Except
as set forth in the Disclosure Schedules and exhibits thereto attached to the Purchase Agreement, as long as at least thirty-three
percent (33%) of the aggregate Principal Amount of the Notes issued pursuant to the Purchase Agreement remains outstanding, the
Company shall not, and shall not permit any of its Subsidiaries to, directly or indirectly:

 

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a)
amend its charter documents, including, without limitation, its certificate of incorporation and bylaws, in any manner that materially
and adversely affects any rights of the Holder;

 

b)
pay cash dividends or distributions on any equity securities of the Company;

 

c)
enter into any transaction with any Affiliate of the Company which would be required to be disclosed in any public filing with
the Commission, unless such transaction is made on an arm’s-length basis and expressly approved by a majority of the disinterested
directors of the Company (even if less than a quorum otherwise required for board approval); or

 

d)
enter into any agreement with respect to any of the foregoing.

 

Section
6. Events of Default.

 

a)
“Event of Default” means, wherever used herein, any of the following events (whatever the reason for such event
and whether such event shall be voluntary or involuntary or effected by operation of law or pursuant to any judgment, decree or
order of any court, or any order, rule or regulation of any administrative or governmental body):

 

i.
any default in the payment of (A) the principal amount of any Note or (B) interest, liquidated damages and other amounts owing
to a Holder on any Note, as and when the same shall become due and payable (whether on a Conversion Date or the Maturity Date
or by acceleration or otherwise) which default, solely in the case of an interest payment or other default under clause (B) above,
is not cured within fifteen (15) Trading Days;

 

ii.
the Company shall fail to observe or perform any other material covenant or agreement contained in the Notes which failure is
not cured, if possible to cure, within the earlier to occur of (A) fifteen (15) Trading Days after notice of such failure sent
by the Holder or by any other Holder to the Company and thirty (30) Trading Days after receipt of written notice thereof;

 

iii.
any material representation or warranty made in this Note or any other Transaction Documents shall be untrue or incorrect in any
material respect as of the date when made that would cause a Material Adverse Effect;

 

iv.
the Company or any Significant Subsidiary (as such term is defined in Rule 1-02(w) of Regulation S-X) shall be subject to a bankruptcy
event; or

 

v.
following the date the Company initially becomes a reporting company pursuant to the Exchange Act and its shares of Common Stock
are listed on a Trading Market, the Common Stock shall subsequently not be eligible for listing or quotation for trading on a
Trading Market and shall not be eligible to resume listing or quotation for trading thereon within ten (10) Trading Days.

 

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b)
Remedies Upon Event of Default. If any Event of Default occurs and is continuing before the Maturity Date, the outstanding
principal amount of this Note, plus liquidated damages, interest and other amounts owing in respect thereof through the date of
acceleration, shall become, at the Holder’s election, immediately due and payable in cash. Commencing fifteen (15) Trading
Days after the occurrence of any Event of Default that results in the eventual acceleration of this Note, the Principal Amount
on this Note shall increase twenty percent (20%). Upon the payment in full, the Holder shall promptly surrender this Note to or
as directed by the Company. In connection with such acceleration described herein, the Holder need not provide, and the Company
hereby waives, any presentment, demand, protest or other notice of any kind, and the Holder may immediately and without expiration
of any grace period enforce any and all of its rights and remedies hereunder and all other remedies available to it under applicable
law. Such acceleration may be rescinded and annulled by Holder at any time prior to payment hereunder and the Holder shall have
all rights as a holder of the Note until such time, if any, as the Holder receives full payment pursuant to this Section 6(b).
No such rescission or annulment shall affect any subsequent Event of Default or impair any right consequent thereon. If this Note
is placed in the hands of an attorney for collection or enforcement or is collected or enforced through any legal proceeding or
the Holder otherwise takes action to collect amounts due under this Note or to enforce the provisions of this Note the Company
shall be obligated and pay reasonable attorneys’ fees in connection with such collection, enforcement or action.

 

Section
7. Miscellaneous.

 

a)
Notices. Any and all notices or other communications or deliveries to be provided by the Holder hereunder, including, without
limitation, any Notice of Conversion, shall be in writing and delivered personally, by e-mail, or sent by a nationally recognized
overnight courier service, addressed to the Company, at the address set forth above, or such other e-mail address, or address
as the Company may specify for such purposes by notice to the Holder delivered in accordance with this Section 7(a). Any
and all notices or other communications or deliveries to be provided by the Company hereunder shall be in writing and delivered
personally, by e-mail, or sent by a nationally recognized overnight courier service addressed to each Holder at the e-mail address,
or address of the Holder appearing on the signature pages attached to the Purchase Agreement. Any notice or other communication
or deliveries hereunder shall be deemed given and effective on the earliest of (i) the date of transmission, if such notice or
communication is delivered via e-mail at the email address set forth on the signature pages attached to the Purchase Agreement
prior to 5:30 p.m. (New York City time) on any date, (ii) the next Trading Day after the date of transmission, if such notice
or communication is delivered via e-mail at the e-mail address set forth on the signature pages attached to the Purchase Agreement
on a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (iii) the second Trading Day
following the date of mailing, if sent by U.S. nationally recognized overnight courier service or (iv) upon actual receipt by
the party to whom such notice is required to be given.

 

b)
Absolute Obligation. Except as expressly provided herein, no provision of this Note shall alter or impair the obligation
of the Company, which is absolute and unconditional, to pay the principal of, liquidated damages and accrued interest, as applicable,
on this Note at the time, place, and rate, and in the coin or currency, herein prescribed. This Note is a direct debt obligation
of the Company.

 

    	9

    	 

    

 

c)
Lost or Mutilated Note. If this Note shall be mutilated, lost, stolen or destroyed, the Company shall execute and deliver,
in exchange and substitution for and upon cancellation of a mutilated Note, or in lieu of or in substitution for a lost, stolen
or destroyed Note, a new Note for the principal amount of this Note so mutilated, lost, stolen or destroyed, but only upon receipt
of evidence of such loss, theft or destruction of such Note, and of the ownership hereof, reasonably satisfactory to the Company.

 

d)
Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Note shall be
governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles
of conflict of laws thereof. Each party agrees that all legal proceedings concerning the interpretation, enforcement and defense
of the transactions contemplated by any of the Transaction Documents (whether brought against a party hereto or its respective
Affiliates, directors, officers, shareholders, employees or agents) shall be commenced in the state and federal courts sitting
in the City of New York, Borough of Manhattan (the “New York Courts”). Each party hereto hereby irrevocably
submits to the exclusive jurisdiction of the New York Courts for the adjudication of any dispute hereunder or in connection herewith
or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement of any of the Transaction
Documents), and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not
personally subject to the jurisdiction of such New York Courts, or such New York Courts are improper or inconvenient venue for
such proceeding. Each party hereby irrevocably waives personal service of process and consents to process being served in any
such suit, action or proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence
of delivery) to such party at the address in effect for notices to it under this Note and agrees that such service shall constitute
good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right
to serve process in any other manner permitted by applicable law. Each party hereto hereby irrevocably waives, to the fullest
extent permitted by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to this
Note or the transactions contemplated hereby. If any party shall commence an action or proceeding to enforce any provisions of
this Note, then the prevailing party in such action or proceeding shall be reimbursed by the other party for its attorney’s
fees and other costs and expenses incurred in the investigation, preparation and prosecution of such action or proceeding.

 

e)
Waiver. Any waiver by the Company or the Holder of a breach of any provision of this Note shall not operate as or be construed
to be a waiver of any other breach of such provision or of any breach of any other provision of this Note. The failure of the
Company or the Holder to insist upon strict adherence to any term of this Note on one or more occasions shall not be considered
a waiver or deprive that party of the right thereafter to insist upon strict adherence to that term or any other term of this
Note on any other occasion. Any waiver by the Company or the Holder must be in writing.

 

f)
Severability. If any provision of this Note is invalid, illegal or unenforceable, the balance of this Note shall remain
in effect, and if any provision is inapplicable to any Person or circumstance, it shall nevertheless remain applicable to all
other Persons and circumstances. If it shall be found that any interest or other amount deemed interest due hereunder violates
the applicable law governing usury, the applicable rate of interest due hereunder shall automatically be lowered to equal the
maximum rate of interest permitted under applicable law. The Company covenants (to the extent that it may lawfully do so) that
it shall not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay,
extension or usury law or other law which would prohibit or forgive the Company from paying all or any portion of the principal
of or interest on this Note as contemplated herein, wherever enacted, now or at any time hereafter in force, or which may affect
the covenants or the performance of this Note, and the Company (to the extent it may lawfully do so) hereby expressly waives all
benefits or advantage of any such law, and covenants that it will not, by resort to any such law, hinder, delay or impede the
execution of any power herein granted to the Holder, but will suffer and permit the execution of every such as though no such
law has been enacted.

 

    	10

    	 

    

 

g)
Next Business Day. Whenever any payment or other obligation hereunder shall be due on a day other than a Business Day,
such payment shall be made on the next succeeding Business Day.

 

h)
Headings. The headings contained herein are for convenience only, do not constitute a part of this Note and shall not be
deemed to limit or affect any of the provisions hereof.

 

i)
Amendment. This Note may be modified or amended or the provisions hereof waived in accordance with the Purchase Agreement.
This Note amends and restates in its entirety the Convertible Note issued to Holder on January __, 2018 which is hereby superseded
in its entirety by the terms hereof.

 

IN
WITNESS WHEREOF, the Company has caused this Note to be duly executed by a duly authorized officer as of the date first above
indicated.

 

	 	Hancock Jaffe Laboratories, Inc.
	 	 	 
	 	By:	 
	 	Name: 	 William Abbott 
	 	Title: 	 Chief Financial Officer 

 

    	11

    	 

    

 

ANNEX
A 

 

NOTICE
OF CONVERSION

 

The
undersigned hereby elects to convert the principal under the Convertible Note (the “Note”) of Hancock Jaffe
Laboratories, Inc., a Delaware corporation (the “Company”), into shares of Common Stock of the Company according
to the conditions hereof, as of the date written below. If shares of Common Stock are to be issued in the name of a person other
than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto and is delivering herewith such
certificates and opinions as reasonably requested by the Company in accordance therewith. No fee will be charged to the holder
for any conversion, except for such transfer taxes, if any. Capitalized terms used but not defined herein shall have the meaning
ascribed to such term in the Note.

 

Conversion
Price: ________________________________________________________________

 

Date
to Effect Conversion: __________________________________________________________

 

Accreted
Value to be Converted: _____________________________________________________

 

Number
of shares of Common Stock to be issued: ________________________________________

 

Cash
to be paid to Holder: __________________________________________________________

 

Signature:
______________________________________________________________________

 

Name:
_________________________________________________________________________

 

Address
for Delivery of Common Share Certificates: ______________________________________

 

Or

 

DWAC
Instructions: ______________________________________________________________

 

Broker
No: ______________________________________________________________________

 

Account
No: ____________________________________________________________________

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