Document:

Exibit 4.1

	

EXHIBIT 4.1 

RESTATED CERTIFICATE OF
INCORPORATION 

OF

IMPATH INC. 

     The
Restated Certificate of Incorporation of IMPATH Inc. (which was originally
incorporated in Delaware on March 1, 1988 under the name Biopath Inc.), is
hereby duly adopted in accordance with Section 245 of the General Corporation
Law of the State of Delaware. This Restated Certificate of Incorporation only
restates and integrates and does not further amend the provisions of the
Restated Certificate of Incorporation of the Corporation as heretofore amended
or supplemented and there is no discrepancy between those provisions and the
provisions of this Restated Certificate of Incorporation. The text of the
Restated Certificate of Incorporation as amended or supplemented heretofore is
hereby restated without further amendments or changes to read as herein set
forth in full: 

ARTICLE I 

NAME 

     The
name of the corporation is: IMPATH Inc. 

ARTICLE II 

PURPOSES 

     The
purpose of the corporation is to engage in any lawful act or activity for which
a corporation may be organized under the General Corporation Law of the State of
Delaware other than the banking business, the trust company business or the
practice of a profession not permitted to be incorporated by the General
Corporation Law of the State of Delaware. 

ARTICLE III 

AGENT FOR SERVICE 

     The
name and address in the State of Delaware of the corporation’s agent for
service of process is: 

	 	The
Corporation Trust Company 
1209 Orange Street, Corporate Trust Center 
Wilmington, Delaware
19801 
County of New Castle, Delaware

	

 

	

ARTICLE IV 

CAPITAL STOCK 

     The
total number of shares of capital stock which the corporation shall have
authority to issue is One Million (1,000,000) shares of preferred stock, $.01
par value per share (the “Preferred Stock”), and Seventy Million
(70,000,000) shares of common stock, $.005 par value per share (the “Common
Stock”). 

     (a)
Common Stock 

     Section
1. Voting Rights. The holders of shares of Common Stock shall be entitled to one vote for
each share so held with respect to all matters voted on by the shareholders of the
corporation. 

Section 2. Liquidation
Rights. Subject to the liquidation rights of holders of Preferred Stock,
upon any voluntary or involuntary liquidation, dissolution or winding up of the
corporation, the holders of Common Stock shall be entitled to receive all assets
of the corporation available for distribution to its stockholders. 

     Section
3. Dividends. Dividends may be paid on the Common Stock as and when declared by the Board
of Directors, out of funds legally available therefor, subject to the rights of holders
of Preferred Stock. 

     Section
4. Rights of First Refusal. A holder of shares of Common Stock shall have the
rights of first refusal, if any, to subscribe to an additional issue of capital stock of
the corporation or of any security convertible into capital stock of the corporation as
are set forth in a Stockholders’Agreement dated on or about February 9, 1995, if
such holder is a party thereto, subject to the terms and conditions off such agreement,
as such agreement may be amended from time to time.  

     (b)
Preferred Stock. The powers, designations, preferences and relative, participating,
optional or other special rights, qualifications, limitations or restrictions of the Preferred Stock shall be as follows:  

     Section
1. (A) The Preferred Stock may be issued from time to time as shares of one or more
series of Preferred Stock, and in the resolution or resolutions providing for the issue
of shares of each particular series, before issuance, the Board of Directors of the
corporation is expressly authorized to fix:  

	 	     (i)
the distinctive designation of such series and the number of shares which shall
constitute such series, which number may be increased (except where otherwise provided by
the Board of Directors in creating such series) or decreased (but not below the number of
shares thereof then outstanding) from time to time by like action of the Board of
Directors;

	

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	 	     (ii)
the rate of dividends payable on such series, whether or not such dividends shall be
cumulative, the date or dates from which dividends shall accrue and, if cumulative, the
relationship with which such dividends shall bear to dividends payable on any other
series;

	 	     (iii)
whether or not the shares of such series shall be subject to redemption by the
corporation and, if so, the times, prices and other terms and conditions of such
redemption; 

	 	     (iv)
whether or not the shares of such series shall be subject to the operation of a sinking
fund or a fund or a similar nature and, if so, the terms thereof;

	 	     (v)
the rights of the shares of each series in case of liquidation, dissolution or winding up
of the corporation, whether voluntary or involuntary, or upon distribution of its assets;

	 	     (vi)
whether or not the shares of such series shall be convertible into or exchangeable for
shares of any other series or class of stock of the corporation and, if so, the terms of
conversion or exchange;

	 	     (vii)
whether or not the shares of such series shall have voting rights in addition to the
voting rights provided by law and in Section 5 below and, if so, the nature and extent
thereof; and

	 	     (viii)
the consideration to be received by the corporation for the shares of such series.

	 	     (B) The
shares of the Preferred Stock of any one series shall be identical with each other in all
respects except as to the dates from which dividends thereon shall accrue or be
cumulative. 

	 	     (C) In
case the stated dividends and the amounts, if any, payable on liquidation, dissolution or
winding up of the corporation are not paid in full, the shares of each series of the
Preferred Stock, after the payment in full of such dividends and amounts to all series of
the Preferred Stock ranking senior to such series and before any payment to any series
ranking junior thereto, shall share ratably in the payment of dividends, including
accumulations, if any, in accordance with the sums which would be payable on said shares
if all dividends were declared and paid in full, and in any distribution of assets other
than by way of dividends, in accordance with the sums which would be payable on such
distribution if all sums payable were discharged in full. 

	

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	 	     (D) Upon
the issuance of any series of Preferred Stock, a certificate setting forth the resolution
or resolutions (including the designation, description ad terms of such series) adopted
by the Board of Directors with respect to such series shall be made and filled in
accordance with the then applicable requirements, if any, of the laws of the State of
Delaware, or, if no certificate is then so required, such certificate shall be signed and
acknowledged on behalf of the corporation by its President or a Vice President, and its
corporate seal shall be affixed thereto and attested by its Secretary or an Assistant
Secretary, and such certificate shall be filed and kept on file at the principal office
of the corporation in the State of Delaware or at such other place or places as the Board
of Directors shall designate. 

	

     Section
2. The holders of each series of the Preferred Stock shall be entitled to receive, when
and as declared by the Board of Directors, but only out of funds of the corporation
legally available for the payment of dividends, dividends in cash at the annual rate for
such series provided by the Board of Directors in the certificate made pursuant to
paragraph (D) of Section 1 with respect to such series, before any dividends shall be
declared and paid upon or set apart for the holders of any series of he Preferred Stock
ranking junior to such series as to dividends or of any Junior Stock (as hereinafter
defined), payable in respect of each calendar quarter on a date, which shall be provided
by the Board of Directors in such certificate with respect to such series, within fifty
(50) days following the end of such quarter. Such dividends on the Preferred Stock shall
be payable to the holders of such series of record on the date, not exceeding fifty (50)
days preceding the dividend payment date, fixed for such purpose by the Board of
Directors with respect to such series in advance of the payment of each particular
dividend.  

     Section
3. If so provided by the Board of Directors in the certificate made pursuant to paragraph
(D) of Section 1 with respect to any series of the Preferred Stock, the corporation may
redeem the whole or any part of such series, at such time or times and from time to time
and at such redemption price or prices as may be provided by the Board of Directors in
such certificate and otherwise upon the terms and conditions fixed by the Board of
Directors for any such redemptions.  

     Section
4. In the event of any liquidation, dissolution or winding up of the corporation, whether
voluntary or involuntary, the holders of each series of the Preferred Stock then
outstanding shall be entitled to receive, after the payment in full of all amounts to
which to which the holders of all series of the Preferred Stock ranking senior thereto
are entitled, out of the assets of the corporation, before any distribution or payment
shall be made to the holders of any series of the Preferred Stock ranking junior to such
series upon liquidation, dissolution or winding up of the corporation or of any Junior
Stock, the amount, if any, for each share provided by the Board of Directors in the
certificate made pursuant to paragraph (D) of Section 1. If payment shall have been made
in full to the holders of each series of the Preferred Stock, the remaining assets of the
corporation shall be distributed among the holders of the Junior Stock, according to
their respective rights and preferences and pro rata in accordance with their respective
holdings.  

	

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     Section
5. On all matters with respect to which holders of the Preferred Stock or of certain
series thereof are entitled to vote as a single class, each holder of Preferred Stock
afforded such class voting right shall be entitled to one vote for each share held.  

     Section
6. For purposes of this Article IV, the term “Junior Stock”shall mean the
Common Stock and any other class of stock of the corporation hereafter authorized which
shall rank junior to all series of the Preferred Stock as to all dividends or preference
on dissolution, liquidation or winding up of the corporation.  

ARTICLE V 

ADDITIONAL PROVISIONS 

     Section
1. Existence. The corporation is to have perpetua1 existence. 

     Section
2. Amendments to By-laws. In furtherance and not in limitation of the powers conferred by
statute, the Board of Directors is authorized to adopt, amend and repeal the by-laws of
the corporation. 

     Section
3. Meetings of Stockholders. Meetings of stockholders may be held within or
without the State of Delaware, as the by-laws may provide. The books of the corporation
may be kept (subject to any provisions contained in the statutes) outside the State of
Delaware at such place or places as may be designated from time to time by the Board of
Directors or in the by-laws of the corporation. Elections of directors need not be by
written ballot unless the by-laws of the corporation shall so provide.  

     Section
4. Number of Directors. The number of directors of the corporation shall be fixed from
time to time by a by-law or amendment thereof adopted by the Board of Directors. 

     Section
5. Amendments to Certificate of Incorporation. The corporation reserves the right
to amend, alter, change or repeal any provision contained in this certificate of
incorporation, in the manner now or hereafter prescribed by statute, and all rights
conferred on stockholders herein are granted subject to this reservation.  

     Section
6. Liability of Directors. No director of the corporation shall be personally
liable to the corporation or any of its stockholders for monetary damages for breach of
fiduciary duty as a director, except for liability, to the extent that such liability is
imposed by applicable law, (i) for any breach of the director’s duty of loyalty to
the corporation or its stockholders, (ii) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, (iii) under Section
174 of the Delaware General Corporation Law, as the same exists or hereafter may be
amended, or any successor provisions or (iv) for any transaction from which the director
derived an improper personal benefit. If the Delaware General Corporation Law is amended
hereafter to authorize the further elimination or limitation of the liability of
directors, then the liability of a director of the corporation, in addition to the
limitation on personal liability provided herein, shall be limited to the fullest extent
permitted by the amended Delaware General Corporation Law. Any repeal or modification of
this Article by the stockholders of the corporation shall be prospective only, and shall
not adversely affect any limitation on the personal liability of a director of the
corporation existing at the time of such repeal or modification.  

	

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     Section
7. Right to Indemnification. 

	 	     (A) Each
person who was or is made a party or is threatened to be made a party to or is involved
in any action, suit or proceeding, whether civil, criminal, administrative or
investigative (hereinafter, a “proceeding”), by reason of the fact that he or
she, or a person of whom she is the legal representative, is or was a director or
officer, of the corporation or, at the request of the corporation, of a partnership,
joint venture, trust or other enterprise, including service with respect to employee
benefit plans, whether the basis of such proceeding is alleged action in any official
capacity as a director, officer, employee or agent or in any other capacity while serving
as a director, officer, employee or agent, shall be indemnified and held harmless by the
corporation to the fullest extent authorized by the Delaware General Corporation Law, as
the same exists or may hereafter be amended (but, in the case of any such amendment, only
to the extent that such amendment permits the corporation to provide broader
indemnification rights than said law permitted the corporation to provide prior to such
amendment), against all expense, liability and loss (including attorneys’ fees,
judgments, fines, excise taxes or penalties under the Employee Retirement Income Security
Act of 1974, as amended, and amounts paid or to be paid in settlement) reasonably
incurred or suffered by such person in connection therewith and such indemnification
shall continue as to a person who has ceased to be a director, officer, employee or agent
and shall inure to the benefit of his or her heirs, executors and administrators; provided,
however, that, except as provided in paragraph (B) of this Article V, Section 7,
the corporation shall indemnify any such person seeking indemnification in connection
with a proceeding (or part thereof) initiated by such person only if such proceeding (or
part thereof) was authorized by the Board of Directors of the corporation. The right to
indemnification conferred in this Article V, Section 7 shall be a contract right and
shall include the right to be paid by the corporation the expenses incurred in defending
any such proceeding in advance of its final disposition; provided, however, that,
if the Delaware General Corporation Law requires, the payment of such expenses incurred
by a director or officer in his or her capacity as a director or officer (and not in any
other capacity in which service was or is rendered by such person while a director or
officer, including, without limitation, service to an employee benefit plan) in advance
of the final disposition of a proceeding, shall be made only upon delivery to the
corporation of an undertaking, by or on behalf of such director or officer, to repay all
amounts so advanced if it shall ultimately be determined that such director or officer is
not entitled to be indemnified under this Article V, Section 7 or otherwise. The
corporation may, by action of its Board of Directors, provide indemnification to
employees and agents of the corporation with the same scope and effect as the foregoing
indemnification of directors and officers. 

	

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	 	     (B) If
a claim under paragraph (A) of this Article V, Section 7 is not paid in full by the
corporation within thirty days after a written claim has been received by the
corporation, the claimant may at any time thereafter bring suit against the corporation
to recover the unpaid amount of the claim and, if successful in whole or in part, the
claimant shall be entitled to be paid also the expense of prosecuting such claim. It
shall be a defense to any such action (other than an action brought to enforce a claim
for expenses incurred in defending any proceeding in advance of its final disposition
where the required undertaking, if any is required, has been tendered to the corporation)
that the claimant has not met the standards of conduct which make it permissible under
the Delaware General Corporation law for the corporation to indemnify the claimant for
the amount claimed, but the burden of proving such defense shall be on the corporation.
Neither the failure of the corporation (including its Board of Directors, independent
counsel, or its stockholders) to have made a determination prior to the commencement of
such action that indemnification of the claimant is proper in the circumstances because
he or she has met the applicable standard of conduct set forth in the Delaware General
Corporation Law, nor an actual determination by the corporation (including its Board of
Directors, independent legal counsel, or its stockholders) that the claimant has not met
such applicable standard or conduct, shall be a defense to the action or create a
presumption that the claimant has not met the applicable standard of conduct. 

	 	     (C) Non-Exclusivity
of Rights. The right to indemnification and the payment of expenses incurred in
defending a proceeding in advance of its final disposition conferred in this Article V,
Section 7 shall not be exclusive of any other right which any person my have or hereafter
acquire under any statute, provision of the certificate of incorporation, by-law,
agreement, vote of stockholders or disinterested directors or otherwise. 

	 	     (D) Insurance.
The corporation may maintain insurance, at its expense, to protect itself and any
director, officer, employee or agent of the corporation or another corporation,
partnership, joint venture, trust or other enterprise against such expense, liability or
loss, whether or not the corporation would have the power to indemnify such person
against such expense, liability or loss under the Delaware General Corporation Law. 

	

     Section
8. Arrangements with Creditors or Stockholders. Whenever a compromise or
arrangement is proposed between this corporation and its creditors or any class of them
and/or between this corporation and its stockholders or any class of them, any court of
equitable jurisdiction within the State of Delaware may, on the application in a summary
way of this corporation or of any creditor or stockholder thereof or on the application
of any receiver or receivers appointed for this corporation under the provisions of
Section 291 of Title 8 of the Delaware Code or on the application of trustees in
dissolution or of any receiver or receivers appointed for this corporation under the
provisions of section 279 of Title 8 of the Delaware Code order a meeting of the
creditors or class of creditors, and/or of the stockholders or class of stockholders of
this corporation, as the case may be, to be summoned in such manner as the said court
directs. If a majority in number representing three-fourths in value of the creditors or
class of creditors, and/or of the stockholders or class of stockholders of this
corporation, as the case may be, agree to any compromise or arrangement and to any
reorganization of this corporation as a consequence of such compromise or arrangement,
the said compromise or arrangement and the said reorganization shall, if sanctioned by
the court to which the said application has been made, be binding on all the creditors or
class of creditors, and/or on all the stockholders or class of stockholders, of this
corporation, as the case may be, and also on this corporation.  

	

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     IN
WITNESS WHEREOF, IMPATH Inc. has caused this Restated Certificate of
Incorporation to be signed this 16th day of July 2002 in its name and on its
behalf by its Secretary, pursuant to Section 103(a) of the General Corporation
Law of the State of Delaware. 

			IMPATH INC.

By: /s/ Richard C. Rosenzweig
——————————————

Name: Richard C. Rosenzweig
Title: Secretary

	

8EX-10.31

	

10.31 

August
7, 2002 

Anu D. Saad, Ph.D. 
C/O Impath Inc. 

521 West 57th Street 

New York, NY 10019 

Dear Anu: 

     The
purpose of this letter agreement (the “Agreement”) is to set forth the
terms of the benefits that you will be entitled to receive if IMPATH Inc. (the
“Company”) undergoes a Change of Control (as defined below) and to
supplement and conform that certain letter agreement, dated December 12, 1997
(the “Letter Agreement”), between you and the Company, with this
Agreement. 

     1. As
used in connection with the following definition of Change in Control, “Affiliate” shall
have the meaning set forth in Rule 12b-2 promulgated under Section 12 of the Exchange
Act; “Beneficial Owner” shall have the meaning set forth in Rule 13d-3 under the
Exchange Act; “Exchange Act” shall mean the Securities Exchange Act of 1934, as
amended from time to time; “Parent” shall mean any entity that becomes the
Beneficial Owner of at least 80% of the voting power of the outstanding voting securities
of the Company or of an entity that survives any merger or consolidation of the Company
or any direct or indirect subsidiary of the Company; and “Person” shall have the
meaning given in Section 3(a)(9) of the Exchange Act, as modified and used in Sections
13(d) and 14(d) thereof, except that such term shall not include (i) the Company or any
of its subsidiaries, (ii) a trustee or other fiduciary holding securities under an
employee benefit plan of the Company or any of its Affiliates, (iii) an underwriter
temporarily holding securities pursuant to an offering of such securities, or (iv) a
corporation or entity owned, directly or indirectly, by the stockholders of the Company
in substantially the same proportions as their ownership of stock of the Company.  

     As
used herein, a “Change in Control” shall be deemed to have occurred if an event
set forth in any one of the following paragraphs shall have occurred:  

	 	     (I)
any Person is or becomes the Beneficial Owner, directly or indirectly, of securities of
the Company (excluding securities acquired directly from the Company or its Affiliates)
representing 35% or more of the combined voting power of the Company’s then
outstanding securities; or

	 	     (II)
Individuals who, as of the date hereof, constitute the Board of Directors of the Company
(the “Incumbent Board”) cease for any reason to constitute at least a majority
of the Board of Directors of the Company; provided that any person becoming a director of
the Company subsequent to the date of this letter whose election, or nomination for
election, was approved by a vote of at least a majority of the directors then comprising
the Incumbent Board (other than a director whose initial assumption of office is in
connection with the settlement of an actual or threatened election contest, including but
not limited to a consent solicitation, relating to the election of directors of the
Company) shall be considered a member of the Incumbent Board; or

	 	     (III)
there is consummated a merger or consolidation of the Company or any direct or indirect
subsidiary of the Company with any other corporation or entity; provided, however, that a
Change in Control shall not be deemed to have occurred with respect to (i) a merger or
consolidation which would result in the voting securities of the Company outstanding
immediately prior to such merger or consolidation continuing to represent (either by
remaining outstanding or by being converted into voting securities of the surviving
entity or any Parent thereof) at least 65% of the combined voting power of the securities
of the Company, such surviving entity or any Parent thereof outstanding immediately after
such merger or consolidation or (ii) a merger or consolidation effected solely to
implement a recapitalization of the Company (or similar transaction) in which no Person
is or becomes the Beneficial Owner, directly or indirectly, of securities of the Company
(not including in the securities beneficially owned by such Person any securities
acquired directly from the Company or its Affiliates) representing 35% or more of the
combined voting power of the Company’s then outstanding securities;

	

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	 	     (IV)
the stockholders of the Company approve a plan of complete liquidation or dissolution of
the Company, or there is consummated a sale or disposition by the Company or any of its
subsidiaries of any assets which individually or as part of a series of related
transactions constitute all or substantially all of the Company’s consolidated
assets (provided that, for these purposes, a sale of all or substantially all of the
voting securities of the Company or a Parent of the Company shall be deemed to constitute
a sale of substantially all of the Company’s consolidated assets); provided,
however, that a Change in Control shall not be deemed to have occurred with respect to
any such sale or disposition to an entity at least 65% of the combined voting power of
the voting securities of which are owned by stockholders of the Company in substantially
the same proportions as their ownership of the voting securities of the Company
immediately prior to such sale or disposition; or

	

     2. (a)
If, during the Term (as described in Section 7 below) (i) a Change in Control occurs or
(ii) your employment by the Company is terminated prior to the date a Change of Control
occurs, and it is reasonably demonstrated that such termination (a) was at the request of
a third party who has taken steps reasonably calculated to effect a Change of Control, or
(b) otherwise arose in connection with or in anticipation of a Change of Control, then
the Company shall pay to you, within 90 days after the date of the Change of Control, as
a payment for services previously rendered to the Company, a lump sum equal to three
times your Annual Compensation (as defined below) in effect immediately prior to the date
of the Change of Control (without regard to any decrease in the rate of your Annual
Compensation made after the Change in Control).  

     (b)
For purposes of this Section 2, “Annual Compensation” shall mean, at any time,
an amount equal to the sum of (i) your annual rate of salary at such time, plus (ii) 100%
of the target bonus or other cash incentive that you are eligible to earn in such year
pursuant to each plan or program (whether or not such plan or program has been formalized
or is in written form) of the Company in effect for such year that provides for bonuses
or other cash incentives, or if no such plan or program has been adopted with respect to
such year, 100% of the target bonus or other cash incentive that you were eligible to
earn in the most recent year in which such a plan or program was in effect.  

     3. (a)
If upon the occurrence of a Change of Control entitling you to receive the payment
provided in Section 2 above on account of an event described in Section 1 above, any
payment or other benefit paid or received or to be paid or received or any property
transferred or to be transferred (collectively, a “Payment”) with respect to
one or more calendar years by or on behalf of the Company (or any affiliate of the
Company) to you pursuant to this letter in connection with the Change in Control shall
constitute an “excess parachute payment” within the meaning of Section 280G(b)
of the Internal Revenue Code of 1986, as amended (the “Code”) subject to the
tax imposed by Section 4999 of the Code (the “Excise Tax”), then the Company
shall pay to you an additional amount (the “Gross Up Payment”) such that the
amount paid or transferred to you, after deduction of any Excise Tax on the Payment, and
any federal, state and local income tax, employment tax and Excise Tax upon the Gross Up
Payment, shall be equal to the Payment. References to the Code hereunder shall be to the
Code as presently in effect or to the corresponding provisions of any succeeding law.  

     (b)
For purposes of determining under Section 3(a) whether any portion of a Payment will be
subject to the Excise Tax and the amount of such Excise Tax, (A) the Payment and payments
provided for in Section 3 shall be treated as “parachute payments” within the
meaning of Section 280G(b)(2) of the Code, and all “excess parachute payments” within
the meaning of Section 280(G)(b)(1) of the Code shall be treated as subject to the Excise
Tax, unless and to the extent that tax counsel selected by the Company’s independent
auditors and acceptable to you is of the opinion that the Payment (in whole or in part)
does not constitute a “parachute payment” or such “excess parachute payment” (in
whole or in part) represents reasonable compensation for services actually rendered
within the meaning of Section 280G(b)(4) of the Code in excess of the allocable base
amount within the meaning of Section 280G(b)(3) of the Code, or the Payment is otherwise
not subject to the Excise Tax, (B) the amount of the Payment that is treated as subject
to the Excise Tax shall be equal to the lesser of (X) the total amount of the Payment,
and (Y) the amount of “excess parachute payments” within the meaning of Section
280G(b)(1) of the Code (after applying clause (A) above), (C) any Gross Up Payment
pursuant to Section 3(a) shall be treated as subject to the Excise Tax in its entirety
and (D) the value of any non-cash benefits or any deferred payment or benefit shall be
determined by the Company’s independent auditors in accordance with the principles
of Sections 280G(d)(3) and (4) of the Code.  

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     (c) If
in circumstances described in Section 3(a), by reason of the filing by you of an amended
tax return, an audit by the Internal Revenue Service or other taxing authority, or a
final determination by a court of competent jurisdiction, it is determined that “excess
parachute payments” exceeding those previously reported in your tax returns were
received by you and as a result an additional Excise Tax (the “Additional Excise Tax”)
shall become due, the Company shall pay you an additional amount (the “Subsequent
Gross Up Payment”) such that the amount paid or transferred to you, after deduction
of (A) any Additional Excise Tax and (B) on an after tax basis, any interest, additions
and penalties with respect to the Additional Excise Tax and (C) any federal, state and
local income tax, employment tax and Excise Tax upon the Subsequent Gross up Payment and
(D) the payments provided for in Section 3(a), shall be equal to the Payment.  

     (d)
Any Gross Up Payment required hereunder shall be made at least ten days prior to the due
date (without regard to extensions) of your federal income tax return for the year with
respect to which the “excess parachute payment” is deemed made under the Code.
Any Subsequent Gross Up Payment required hereunder shall be made to you within 30 days
after the amount thereof is determined. Notwithstanding the two immediately preceding
sentences, the Company shall pay any federal, state and local tax or taxes and employment
taxes required to be withheld from your wages (within the meaning of Section 3121 and
3402 of the Code) with respect to the “excess parachute payment” and any such
tax or taxes paid by the Company to the Internal Revenue Service or state or local taxing
authority shall constitute payment to you.  

     (e) If
the Excise Tax is finally determined (whether by the filing of an amended tax return by
you by audit of the Internal Revenue Service or other taxing authority, or by a final
determination of a court of competent jurisdiction) to be less than the amount paid to or
on behalf of you under the provisions of Sections 3(a)-(d) and the overpayment is
refunded to you, you shall repay to the Company, promptly following the receipt of the
refund, the portion of the Gross Up Payment (and/or Subsequent Gross Up Payment)
attributable to such reduction of the Excise Tax (plus the portion attributable to
federal, state and local income tax and employment taxes imposed on the portion being
repaid by you but only to the extent that the repayment may result in a tax benefit to
you under Section 1341 of the Code and similar provisions of applicable state and local
law).  

     4. (a)
The first sentence of Section 1 of the Letter Agreement is hereby amended by deletion of
(i) the first ten lines of such section through the word “Company” and substitution of
the phrase “Upon the occurrence of a Change of Control, as defined in the letter
agreement, dated August 7, 2002, between the Company and you,” (ii) the
remainder of such sentence after the phrase “evidencing the Options,” and (iii)
deletion From Section 1 of the Letter Agreement of the phrase “event described in
clause (i) or (ii) of the foregoing sentence” and substitution of the phrase “Change
of Control.” 

     (b)
All stock options for the purchase of common stock of the Company awarded to you on or
subsequent to September 12, 1997 are hereby amended to provide that upon a Change of
Control, as set forth in this Agreement, such stock options shall become exercisable in
full, notwithstanding any provision of the stock option plan of the Company pursuant to
which the options were granted or of the stock option agreements or certificates
evidencing the options.  

     (c)
With respect to any stock options awarded to you which are incentive stock options, the
provisions of this Section 4 shall apply to the extent permitted by Section 422(d) of the
Code, and such options in excess thereof shall, immediately upon A Change of Control, be
treated for all purposes as non-qualified stock options and shall be immediately
exercisable.  

3 

	

     (d)
Except as provided in Section 1 of the Letter Agreement as amended hereby, the provisions
of the Letter Agreement shall have no application to a Change of Control and shall not
result in benefits to you upon or in connection with a Change of Control.  

     5.
Nothing in this Agreement (a) confers upon you the right to continue in the employment of
the Company or the right to hold any particular office or position with the Company, (b)
requires the Company to pay you, or entitles you to receive, any specified annual salary
or interferes with or restricts in any way the right of the Company to decrease your
annual salary at any time, (c) interferes with or restricts in any way the right of the
Company to terminate your employment at any time, with or without cause, or (d) except as
provided herein, limits or amends the provisions of the Letter Agreement..  

     6. Any
payments due you hereunder shall be reduced by all applicable withholding and other taxes. 

     7. The
provisions set forth in this Agreement shall continue in effect throughout its Term. For
these purposes, the Term hereunder shall commence as of August 1, 2002 and continue until
July 31, 2005. The Term shall be extended and renewed automatically for one additional
year on August 1, 2005, and on each August 1 thereafter, unless (a) you give
notice of your intent to terminate your employment, or otherwise terminate your
employment, before such date, or (b) the Company gives contrary written notice to you at
least 90 days prior to any such renewal date. Notwithstanding the foregoing, the Company
shall not terminate or fail to renew this Agreement (a) at the request of a third party
who has taken steps reasonably calculated to effect a Change of Control or (b) otherwise
in connection with or in anticipation of a Change of Control. Any such notice shall be
deemed null and void and of no force or effect.  

     This
Agreement is intended to be binding upon the Company, its successors in interest and
assigns and shall supersede and replace all other agreements (written or oral) with you
relating to benefits upon a Change of Control, except as expressly provided herein.  

     Notwithstanding
anything to the contrary contained elsewhere in this Agreement, the Compensation
Committee (the “Committee”) of the Board of Directors of the Company shall have
the authority to interpret, on behalf of the Company, the provisions of this Agreement.
The decisions of the Committee shall govern the interpretation of this Agreement,
notwithstanding any authority otherwise provided under this Agreement to another
individual, group of individuals or entity herein, including, but not limited to, the
authority to determine the eligibility for, amount, form and timing of payments
hereunder, and the calculation of “excess parachute payments” and the underlying
elements used in their determination under Code Section 280G.  

     8.
This Agreement shall be subject to, and governed by, the laws of the State of New York
applicable to contracts made and to be performed in the State of New York, regardless of
where you are in fact required to work and without reference to the conflict of law
provisions thereof.  

			Very truly
      yours, 

      

      IMPATH Inc.

      

      

      By: /s/ Richard C. Rosenzweig

             ——————————————

             Name: Richard C. Rosenzweig

             Title: Vice President and General Counsel 

	

Agreed and Accepted: 

By: /s/ Anu D. Saad, Ph.D.

         ———————————

         Name: Anu D. Saad, Ph.D. 

Date: 8/7/02

            ——————————

4

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