Document:

Exhibit 10.12 

DENTAL PATIENT CARE AMERICA, INC.

 

2006 STOCK OPTION PLAN

 

1. Purpose; Effectiveness of the Plan.

 

(a) The purpose of this Plan is to advance the interests of the Company and its shareholders by helping the Company obtain and retain the services of employees, officers, consultants, independent contractors, directors, and others upon whose judgment, initiative and efforts the Company is substantially dependent, and to provide those persons with further incentives to advance the interests of the Company.

 

(b) This Plan will become effective on the date of its adoption by the Board. This Plan will remain in effect until it is terminated by the Board under Section 9 hereof or until the ten year anniversary of Board approval of the Plan, whichever is earlier, except that no option will be granted after the tenth anniversary of the date of this Plan’s adoption by the Board and no option granted hereunder shall expire by reason of the termination of the Plan. This Plan will be governed by, and construed in accordance with, the laws of the State of Utah.

 

2. Certain Definitions. Unless the context otherwise requires, the following defined terms (together with other capitalized terms defined elsewhere in this Plan) will govern the construction of this Plan, and of any stock option agreements entered into pursuant to this Plan:

 

(a) “1933 Act” means the Federal Securities Act of 1933, as amended;

 

(b) “Board” means the Board of Directors of the Company;

 

(c) “Code” means the Internal Revenue Code of 1986, as amended (references herein to Sections of the Code are intended to refer to Sections of the Code as enacted at the time of this Plan’s adoption by the Board and as subsequently amended, or to any substantially similar successor provisions of the Code resulting from recodification, renumbering or otherwise);

 

(d) “Company” means Dental Patient Care America, Inc., a Utah corporation;

 

(e) “Eligible Participants” means persons who, at the time of grant, are members of the Dental Cooperative and such other persons or entities whom the Board may select from time to time;

 

(f) “Option” means an option granted pursuant to this Plan entitling the option holder to acquire shares of Stock issued by the Company pursuant to the valid exercise of the option;

 

(g) “Option Agreement” means an agreement between the Company and an Optionee, in form and substance satisfactory to the Board in its sole discretion, consistent with this Plan;

 

(h) “Option Price” with respect to any particular Option means the exercise price at which the Optionee may acquire each share of the Option Stock called for under such Option;

 

(i) “Option Stock” means Stock issued or issuable by the Company pursuant to the valid exercise of an Option;

 

(j) “Optionee” means an Eligible Participant to whom Options are granted hereunder, and any transferee thereof pursuant to a Transfer authorized under this Plan;

 

(k) “Plan” means this 2006 Stock Option Plan of the Company;

 

(l) “QDRO” has the same meaning as “qualified domestic relations order” as defined in Section 414(p) of the Code;

 

 

(m) “Stock” means shares of the Company’s common stock, no par value;

 

(n) “subsidiary” has the same meaning as “Subsidiary Corporation” as defined in Section 424(f) of the Code; and

 

(o) “Transfer,” with respect to Option Stock, includes, without limitation, a voluntary or involuntary sale, assignment, transfer, conveyance, pledge, hypothecation, encumbrance, disposal, loan, gift, attachment or levy of such Option Stock. 

 

3. Eligibility. The Company may grant Options under this Plan only to persons who are Eligible Participants as of the time of such grant. Subject to the provisions of Sections 5 and 6 hereof, there is no limitation on the number of Options that may be granted to an Eligible Participant.

 

4. Administration. 

 

	
             
 	
            (a) General. The Board will administer this Plan.
 

 

 (b) Authority and Discretion of Board. The Board will have full and final authority in its discretion, at any time and from time to time, subject only to the express terms, conditions and other provisions of the Company’s Articles of Incorporation, Bylaws and this Plan, and the specific limitations on such discretion set forth herein:

 

	
             
 	
            (i)
 	
            to select and approve the persons who will be granted Options under this Plan from among the Eligible Participants, and to grant to any person so selected one or more Options to purchase such number of shares of Option Stock as the Board may determine;
 

 

	
             
 	
            (ii)
 	
            to determine the period or periods of time during which Options may be exercised, the Option Price and the duration of such Options, and other matters to be determined by the Board in connection with specific Option grants and Option Agreements as specified under this Plan; and
 

	
             
 	
            (iii)
 	
            to interpret this Plan, to prescribe, amend and rescind rules and regulations relating to this Plan, and to make all other determinations necessary or advisable for the operation and administration of this Plan.
 

(c) Option Agreements. Options will be deemed granted hereunder only upon the execution and delivery of an Option Agreement by the Optionee and a duly authorized officer of the Company. Options will not be deemed granted hereunder merely upon the authorization of such grant by the Board.

 

5. Shares Reserved for Options.

 

(a) Option Pool. The aggregate number of shares of Option Stock that may be issued pursuant to the exercise of Options granted under this Plan will not exceed 2,000,000 shares of Stock (the “Option Pool”), provided that such number will be increased by the number of shares of Option Stock that the Company subsequently may reacquire through repurchase or otherwise. Shares of Option Stock that would have been issuable pursuant to Options, but that are no longer issuable because all or part of those Options have terminated or expired, will be deemed not to have been issued for purposes of computing the number of shares of Option Stock remaining in the Option Pool and available for issuance. 

 

(b) Adjustments Upon Changes in Stock. In the event of any change in the outstanding Stock of the Company as a result of a stock split, reverse stock split, stock dividend, recapitalization, combination or reclassification, appropriate proportionate adjustments will be made in: (i) the aggregate number of shares of Option Stock in the Option Pool that may be issued pursuant to the exercise of Options granted hereunder; (ii) the Option Price and the number of shares of Option Stock called for in each outstanding Option granted hereunder; and (iii) other rights and matters determined on a per share basis under this Plan of any Option Agreement hereunder. Any such adjustments will be made only by the Board, and when so made will be effective, conclusive and binding for all purposes with respect to this Plan and all Options then outstanding. No such
adjustments will be required by reason of the issuance or sale by the Company for cash or other consideration of additional shares of its Stock or securities convertible into or exchangeable for shares of its Stock.

 

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6. Terms of Stock Option Agreements. Each Option granted pursuant to this Plan will be evidenced by an agreement (an “Option Agreement”) between the Company and the person to whom such Option is granted, in form and substance satisfactory to the Board in its sole discretion, consistent with this Plan. Without limiting the foregoing, each Option Agreement (unless otherwise stated therein) will be deemed to include the following terms and conditions:

 

(a) Covenants of Optionee. At the discretion of the Board, the person to whom an Option is granted hereunder, as a condition to the granting of the Option, must execute and deliver to the Company a confidential information agreement approved by the Board. Nothing contained in this Plan, any Option Agreement or in any other agreement executed in connection with the granting of an Option under this Plan will confer upon any Optionee any right with respect to the continuation of his or her status as an employee of, consultant or independent contractor to, or director of, the Company or its subsidiaries.

 

(b) Vesting Periods. Except as otherwise provided herein, each Option Agreement may specify the period or periods of time within which each Option or portion thereof will first become exercisable (the “Vesting Period”) with respect to the total number of shares of Option Stock called for thereunder (the “Total Award Option Stock”). Such Vesting Periods will be fixed by the Board in its discretion, and may be accelerated or shortened by the Board in its discretion.

 

(c) Exercise of the Option.

 

	
             
 	
            (i)
 	
            Mechanics and Notice. An Option may be exercised to the extent exercisable (1) by giving written notice of exercise to the Company, specifying the number of full shares of Option Stock to be purchased and accompanied by full payment of the Option Price thereof and the amount of withholding taxes pursuant to Subsection 6(c)(ii) below; and (2) by giving assurances satisfactory to the Company that the shares of Option Stock to be purchased upon such exercise are being purchased for investment and not with a view to resale in connection with any distribution of such shares in violation of the 1933 Act and that such exercise does not otherwise violate the provisions of the 1933 Act or any state securities laws; provided, however, that in the event the Option Stock called for under the Option is registered under the 1933 Act, or in the event
resale of such Option Stock without such registration would otherwise be permissible, this second condition will be inoperative if, in the opinion of counsel for the Company, such condition is not required under the 1933 Act, or any other applicable law, regulation or rule of any governmental agency.
 

 

	
             
 	
            (ii)
 	
            Withholding Taxes. As a condition to the issuance of the shares of Option Stock upon full or partial exercise of an Option granted under this Plan, the Optionee will pay to the Company in cash, or in such other form as the Board may determine in its discretion, the amount of the Company’s tax withholding liability required in connection with such exercise. For purposes of this Subsection 6(c)(ii), “tax withholding liability” will mean all federal and state income taxes, social security tax, and any other taxes applicable to the compensation income arising from the transaction required by applicable law to be withheld by the Company.
 

 

(d) Payment of Option Price. Each Option Agreement will specify the Option Price with respect to the exercise of Option Stock thereunder, to be fixed by the Board in its discretion. The Option Price will be payable to the Company in United States dollars in cash or by check or, such other legal consideration as may be approved by the Board, in its discretion.

 

	
             
 	
            (i)
 	
            For example, the Board, in its discretion, may permit a particular Optionee to pay all or a portion of the Option Price, and/or the tax withholding liability set forth in Subsection 6(c)(ii) above, with respect to the exercise of an Option either by surrendering shares of Stock already owned by such Optionee or by withholding shares of Option Stock, provided that the Board determines that the fair market value of such surrendered Stock or withheld Option Stock is equal to the corresponding portion of such Option Price and/or tax withholding liability, as the case may be, to be paid for therewith.
 

(e) Termination of the Option. Except as otherwise provided herein, each Option Agreement will specify the period of time, to be fixed by the Board in its discretion, during which the Option granted therein will be 

 

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exercisable, not to exceed ten (10) years from the date of grant (the “Option Period”). In the event of a merger or consolidation or other reorganization (a “Corporate Transaction”) in which the Company is not the surviving corporation, or in which the Company becomes a subsidiary of another corporation, then notwithstanding anything else herein, the right to exercise all then outstanding Options will vest immediately prior to such Corporate Transaction and will terminate immediately after such Corporate Transaction; provided, however, that if the Board, in its sole discretion, determines that such immediate vesting of the right to exercise outstanding Options is not in the best interests of the Company, then the successor corporation must agree to assume the outstanding Options or substitute therefor comparable options of such successor corporation or a parent or subsidiary of such
successor corporation.

 

(f) Options Nontransferable. No Option will be transferable by the Optionee otherwise than by will or the laws of descent and distribution or pursuant to a QDRO. During the lifetime of the Optionee, the Option will be exercisable only by him or her, or the transferee of an Option if it was transferred pursuant to a QDRO.

 

(g) Qualification of Stock. The right to exercise an Option will be further subject to the requirement that if at any time the Board determines, in its discretion, that the listing, registration or qualification of the shares of Option Stock called for thereunder upon any securities exchange or under any state or federal law, or the consent or approval of any governmental regulatory authority, is necessary or desirable as a condition of or in connection with the granting of such Option or the purchase of shares of Option Stock thereunder, the Option may not be exercised, in whole or in part, unless and until such listing, registration, qualification, consent or approval is effected or obtained free of any conditions not acceptable to the Board, in its discretion.

 

(h) Restrictions on Transfer of Option Stock. By accepting Options and/or Option Stock under this Plan, the Optionee will be deemed to represent, warrant and agree as follows:

 

(i) Securities Act of 1933. The Optionee understands that the shares of Option Stock have not been registered under the 1933 Act, and that such shares are not freely tradeable and must be held indefinitely unless such shares are either registered under the 1933 Act or an exemption from such registration is available. The Optionee understands that the Company is under no obligation to register the shares of Option Stock. The Optionee further understands that the certificates evidencing the Option Stock will bear a legend describing the restrictions on transfer and shall be in a form determined by the Board in its sole discretion. 

 

(ii) Investment Intent. (1) Upon exercise of any Option, the Optionee will purchase the Option Stock for his or her own account and not with a view to distribution within the meaning of the 1933 Act, other than as may be effected in compliance with the 1933 Act and the rules and regulations promulgated thereunder; (2) no one else will have any beneficial interest in the Option Stock; and (3) he or she has no present intention of disposing of the Option Stock at any particular time. 

 

(i) Additional Restrictions on Exercise and Transfer. The Optionee further understands that exercise of the Option and/or Transfer of the Option Stock requires full compliance with the provisions of all applicable laws. 

 (j) Compliance with Law. Notwithstanding any other provision of this Plan, Options may be granted pursuant to this Plan, the Option Stock may be issued pursuant to the exercise thereof by an Optionee, only after there has been compliance with all applicable federal and state securities laws, and all of the same will be subject to this overriding condition. The Company will not be required to register or qualify Option Stock with the Securities and Exchange Commission or any State agency, except that the Company will register with, or as required by local law, file for and secure an exemption from such registration requirements from, the applicable securities administrator and other officials of each jurisdiction in which an Eligible Participant would be granted an Option hereunder prior to such grant.

 

(k) Stock Certificates. Certificates representing the Option Stock issued pursuant to the exercise of Options will bear all legends required by law and necessary to effectuate this Plan’s provisions. The Company may place a “stop transfer” order against shares of the Option Stock until all restrictions and conditions set forth in this Plan and in the legends referred to in this Section 6(k) have been complied with.

 

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(l) Market Standoff. To the extent requested by the Company and any underwriter of securities of the Company in connection with a firm commitment underwriting, no holder of any shares of Option Stock will sell or otherwise Transfer any such shares not included in such underwriting, or not previously registered pursuant to a registration statement filed under the 1933 Act, during the one hundred eighty (180) day period following the effective date of the registration statement filed with the Securities and Exchange Commission in connection with such offering, which period may be reduced in the sole discretion of the Company.

 

(m) Notices. Any notice to be given to the Company under the terms of an Option Agreement will be addressed to the Company at its principal executive office, Attention: Corporate Secretary, or at such other address as the Company may designate in writing. Any notice to be given to an Optionee will be addressed to the Optionee at the address provided to the Company by the Optionee. Any such notice will be deemed to have been duly given if and when enclosed in a properly sealed envelope, addressed as aforesaid, registered and deposited, postage and registry fee prepaid, in a post office or branch post office regularly maintained by the United States Government.

 

(n) Other Provisions. The Option Agreement may contain such other terms, provisions and conditions, including restrictions on the Transfer of Option Stock issued upon exercise of any Options granted hereunder, not inconsistent with this Plan, as may be determined by the Board in its sole discretion.

 

7. Proceeds from Sale of Stock. Cash proceeds from the sale of shares of Option Stock issued from time to time upon the exercise of Options granted pursuant to this Plan will be added to the general funds of the Company and as such will be used from time to time for general corporate purposes.

 

8. Modification, Extension and Renewal of Options. Subject to the terms and conditions and within the limitations of this Plan, the Board may modify this Plan, or accept the surrender of outstanding Options (to the extent not theretofore exercised) and authorize the granting of new Options in substitution therefor. Notwithstanding the foregoing, however, no modification of any Option will, without the consent of the holder of the Option, alter or impair any rights or obligations under any Option theretofore granted under this Plan.

 

9. Amendment and Discontinuance. The Board may amend, suspend or discontinue this Plan at any time or from time to time; provided that no such action may alter or impair any Option previously granted under this Plan without the consent of the holder of such Option.

 

10. Copies of Plan. A copy of this Plan will be delivered to each Optionee at or before the time he or she executes an Option Agreement.

 

	
             
 	
            Date Plan Adopted by Board of Directors: June 6, 2006
 

 

 

 

 

 

 

 

 

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Exhibit 4.1    
    

AMENDMENT TO THE RIGHTS AGREEMENT

        This
Amendment to the Rights Agreement (this "Amendment") is entered into as of April 9, 2008, between Millennium
Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and Computershare Trust Company, N.A. (as successor Rights Agent to State Street
Bank and Trust Company), as rights agent (the "Rights Agent"). 

INTRODUCTION 

        The Company and the Rights Agent have entered into the Rights Agreement dated as of April 5, 2001 (the "Rights
Agreement"). 

        The
Company, Takeda America Holdings, Inc., a New York corporation ("Parent"), and Mahogany Acquisition Corp., a Delaware
corporation and wholly-owned subsidiary of Parent ("Merger Sub"), intend to enter into an Agreement and Plan of Merger (the
"Merger Agreement") pursuant to which, among other things, Merger Sub shall commence a cash tender offer (the
"Offer") to purchase all the shares of common stock of the Company, par value $0.001 per share (the "Company Common
Stock"). Following the consummation of the Offer, Merger Sub will merge with and into the Company (the "Merger") and the Company
Common Stock will be converted into the right to receive $25.00 per share in cash. 

        Section 27
of the Rights Agreement provides that, for so long as the Rights (as defined in the Rights Agreement) are then redeemable, and subject to certain exceptions that do not
apply to the amendments contemplated hereby, the Company may, in its sole and absolute discretion, and the Rights Agent shall, if the Company so directs, supplement or amend any provision of the
Rights Agreement in any respect without the approval of any holders of the Rights. On April 9, 2008, the Board of Directors of the Company resolved to amend the Rights Agreement as set forth
herein in order to render the Rights inapplicable to the Offer, the Merger and the other transactions contemplated by the Merger Agreement. 

        The
Company and the Rights Agent therefore agree as follows: 

        1.    Capitalized Terms.    All capitalized, undefined terms used in this Amendment shall have the meanings assigned
thereto in the Rights Agreement. 

        2.    Amendments.    

        (a)   The
definition of "Acquiring Person" in Section 1(a) of the Rights Agreement is hereby amended to add the following to the end thereof: 

        "In
addition, notwithstanding anything in this Agreement to the contrary, none of Takeda America Holdings, Inc., Mahogany Acquisition Corp., or any of their Affiliates or
Associates, individually or collectively, shall be an "Acquiring Person" solely by reason of: (1) the approval, adoption, execution or delivery of the Agreement and Plan of Merger (as it may be
amended and supplemented, the "Merger Agreement") among the Company, Takeda America Holdings, Inc., a Delaware corporation
("Parent"), and Mahogany Acquisition Corp., a Delaware corporation and a wholly-owned subsidiary of Parent ("Merger
Sub"), pursuant to which Merger Sub shall commence a cash tender offer to purchase all the shares of Common Stock (the "Offer"),
Merger Sub shall be merged with and into the Company, and the Company shall continue as the surviving corporation and as an indirect wholly-owned subsidiary of Parent (the
"Merger"), (2) the commencement or consummation of the Offer, (3) the exercise of the option to purchase shares of Common Stock granted
pursuant to Section 1.4 of the Merger Agreement (the "Top-Up Option"), (4) the consummation of the Merger, (5) the
approval, execution or delivery of the Support Agreement or any amendments thereof or (6) the consummation of any of the other transactions contemplated by the Merger Agreement or Support
Agreement." 

 

        (b)   The
definition of "Beneficial Ownership" in Section 1(e) of the Rights Agreement is hereby amended to add the following sentence at the end thereof: 

        "Notwithstanding
anything in this definition of Beneficial Ownership to the contrary, none of Parent, Merger Sub, or any of their Affiliates or Associates, individually or collectively,
shall be deemed the "Beneficial Owner" or shall be deemed to "beneficially own" any shares of Common Stock solely as a result of (1) the approval, adoption, execution or delivery of the Merger
Agreement, (2) the commencement or consummation of the Offer, (3) the exercise of the Top-Up Option, (4) the consummation of the Merger, (5) the approval,
execution or delivery of the Support Agreement or any amendments thereof or (6) any of the other transactions contemplated by the Merger Agreement or Support Agreement. 

        (c)   The
definition of "Final Expiration Date" in Section 1(s) of the Rights Agreement is hereby amended and restated in its entirety to read as follows: 

        "
'Final Expiration Date' shall mean the earlier of (i) the close of business on April 5, 2011 and (ii) the Effective Time, as such term is defined in the Merger
Agreement. In the event that the Final Expiration Date means the Effective Time, the Company shall promptly notify the Rights Agent after the occurrence of such Effective Time." 

        (d)   The
definition of "Stock Acquisition Date" in Section 1(ii) of the Rights Agreement is hereby amended to add the following sentence at the end thereof: 

        "Notwithstanding
anything in this Agreement to the contrary, no Stock Acquisition Date shall be deemed to have occurred solely as a result of (u) the approval, adoption, execution
or delivery of the Merger Agreement, (v) the commencement or consummation of the Offer, (w) the exercise of the Top-Up Option, (x) the consummation of the Merger,
(y) the approval, execution or delivery of the Support Agreement or any amendments thereof or (z) the consummation of any of the other transactions contemplated by the Merger Agreement
or Support Agreement." 

        (e)   The
definition of "Section 11(a)(ii) Event" in Section 1(ee) of the Rights Agreement is hereby amended to add the following at the end thereof immediately
prior to the period: 

        ";
PROVIDED, HOWEVER, that, notwithstanding anything in this Agreement to the contrary, a Section 11(a)(ii) Event shall be deemed not to have occurred, and the provisions of such
section shall not be made or given effect, solely as a result of (u) the approval, adoption, execution or delivery of the Merger Agreement, (v) the commencement or consummation of the
Offer, (w) the exercise of the Top-Up Option, (x) the consummation of the Merger, (y) the approval, execution or delivery of the Support Agreement or any amendments
thereof or (z) the consummation of any of the other transactions contemplated by the Merger Agreement or Support Agreement" 

        (f)    The
definition of "Section 13 Event" in Section 1(gg) of the Rights Agreement is hereby amended to add the following at the end thereof immediately prior
to the period: 

        ";
PROVIDED, HOWEVER, that, notwithstanding anything in this Agreement to the contrary, a Section 13 Event shall be deemed not to have occurred, and the provisions of such section
shall not be made or given effect, solely as a result of (u) the approval, adoption, execution or delivery of the Merger Agreement, (v) the commencement or consummation of the Offer,
(w) the exercise of the Top-Up Option, (x) the consummation of the Merger, (y) the approval, execution or delivery of the Support Agreement or any amendments thereof
or (z) the consummation of any of the other transactions contemplated by the Merger Agreement or Support Agreement" 

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        (g)   Section 7(a)
of the Rights Agreement is hereby amended and restated in its entirety to read as follows: 

        "(a) Subject
to Section 7(e) hereof, the registered holder of any Rights Certificate may exercise the Rights evidenced thereby (except as otherwise provided herein
including, without limitation, the restrictions on exercisability set forth in Section 9(c), Section 11(a)(iii) and Section 23 hereof) in whole or in part at any time after the
Distribution Date upon surrender of the Rights Certificate, with the form of election to purchase and the certificate on the reverse side thereof duly executed, to the Rights Agent at the office of
the Rights Agent designated for such purpose, together with payment of the aggregate Purchase Price with respect to the total number of one one-thousandths of a share of Preferred Stock
(or other shares, securities, cash or other assets, as the case may be) as to which such surrendered Rights are then exercisable, at or prior to the earliest of (i) the Final Expiration Date,
(ii) the time at which the Rights expire as provided in Section 13(d) hereof, (iii) the time at which the Rights are redeemed as provided in Section 23 hereof (the
"Redemption Date"), (iv) the time at which such Rights are exchanged as provided in Section 24 hereof and (v) the time immediately prior to the Acceptance Time (as defined in the
Merger Agreement) (the earliest of (i), (ii), (iii), (iv) and (v) being herein referred to as the "Expiration Date")." 

        (h)   The
definition of "Distribution Date" in Section 1(n) of the Rights Agreement is hereby amended to add the following at the end thereof immediately prior to the
period: 

        ";
PROVIDED, HOWEVER, that, notwithstanding anything in this Agreement to the contrary, a Distribution Date shall be deemed not to have occurred solely as a result of (u) the
approval, adoption, execution or delivery of the Merger Agreement, (v) the commencement or consummation of the Offer, (w) the exercise of the Top-Up Option, (x) the
consummation of the Merger (y) the approval, execution or delivery of the Support Agreement or any amendments thereof or (z) the
consummation of any of the other transactions contemplated by the Merger Agreement or Support Agreement" 

        (i)    Section 1
of the Rights Agreement is amended by adding thereto subsections (nn) through (oo) which shall read as follows: 

        "(nn)  "Support
Agreement" shall mean the Tender and Support Agreement, dated on or about April 10, 2008, between Parent and each of the stockholders party thereto. 

        (oo) Each
of "Merger Agreement", "Parent", "Merger Sub", "Offer", "Merger" and "Top-Up Option" shall have the meanings given to such terms in the definition of
"Acquiring Person". 

        3.    Effective Date.    This Amendment shall become effective as of the date first written above, but such
effectiveness is contingent upon the execution and delivery of the Merger Agreement by the parties thereto. 

        4.    Interpretation.    The term "Agreement" as used in the Rights Agreement shall be deemed to refer to the Rights
Agreement as amended by this Amendment. 

        5.    Effect of Amendment.    Except as expressly provided herein, the Rights Agreement shall be and remain in full
force and effect. 

        6.    Governing Law.    This Amendment shall be governed by, and construed in accordance with, the laws of the State
of Delaware (without giving effect to any conflict of laws principles that would cause the application of the laws of any other jurisdiction). 

        7.    Counterparts.    This Amendment may be executed in any number of counterparts and each of such counterparts
shall for all purposes be deemed to be an original, and all such counterparts shall together constitute but one and the same instrument. 

3

 

        8.    Certification.    The officer of the Company executing this Amendment, being an appropriate officer of the
Company and authorized to do so by resolution of the Board of Directors of the Company duly adopted and approved at a meeting held on April 9, 2008, hereby certifies to the Rights Agent that
the supplements and amendments to the Rights Agreement set forth in this Amendment are in compliance with the terms of Section 27 of the Rights Agreement. 

        9.    Severability.    If any term, provision, covenant or restriction of this Amendment is held by a court of
competent jurisdiction or other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment shall remain in full force and
effect and shall in no way be affected, impaired or invalidated. 

        10.    Descriptive Headings.    Descriptive headings of the several Sections of this Amendment are inserted for
convenience only and shall not control or affect the meaning or construction of any of the provisions hereof. 

[Remainder of page intentionally left blank]  

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        IN WITNESS WHEREOF, the Company has executed this Amendment as of the date first above written. 

	 	 	MILLENNIUM PHARMACEUTICALS, INC.
	

 	
 	

By:	

/s/  LAURIE B. KEATING      
 Name: Laurie B. Keating

Title: Senior Vice President and General Counsel

        IN
WITNESS WHEREOF, the Rights Agent has executed this Amendment as of the date first above written. 

	 	 	COMPUTERSHARE TRUST COMPANY, N.A.
	

 	
 	

By:	

/s/  TYLER HAYNES      
 Name: Tyler Haynes

Title: Manager

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Exhibit 4.1

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