Document:

Change in Terms Agreement

 Exhibit 10.1 

CHANGE IN TERMS AGREEMENT 
  

															
	 Principal
	 	 Loan Date
	 	 Maturity
	  	 Loan No
	  	Call / Coll	  	 Account
	  	Officer	  	Initials
	 $6,500,000.00
	 	08-31-2010	 	06-30-2012	  	0083976-0001	  		  	0083976-0001	  	07738	  	

 References in the boxes above are for Lender’s use only and do not limit the applicability of
this document to any particular loan or item. 
 Any item above containing “***” has been omitted due to text length
limitations. 
  

							
	Borrower:	  	 IRIS International, Inc.

9172 Eton Avenue
 Chatsworth, CA
91311
	  	Lender:	  	 California Bank & Trust

Los Angeles Commercial Banking
 550
South Hope Street, Suite 300
 Los Angeles, CA 90071

 

			
	 Principal Amount:    $6,500,000.00
	  	Date of Agreement:    August 31, 2010

DESCRIPTION OF EXISTING INDEBTEDNESS. The Business Loan Agreement dated March 24, 2006 and the Promissory Note dated February 7, 2002,
in the original amount of $6,500,000.00, as amended by those certain Change in Terms Agreements dated Mach 11, 2002, April 24, 2003, October 8, 2003, May 25, 2004, July 29, 2005, March 24, 2006 and
May 1, 2008, from IRIS International, Inc. to Lender, and that certain Extension Letters dated June 8, 2010. 
 DESCRIPTION OF
COLLATERAL. All inventory, equipment, accounts (including but not limited to all health-care-insurance receivables), chattel paper, instruments (including but not limited to all promissory notes), letter-of-credit rights, letters of credit,
documents, deposit accounts, investment property, money, other rights to payment and performance, and general intangibles (including but not limited to all software and all payment intangibles); all fixtures; all attachments, accessions,
accessories, fittings, increases, tools, parts, repairs, supplies, and commingled goods relating to the foregoing property, and all additions, replacements of and substitutions for all or any part of the foregoing property; all insurance refunds
relating to the foregoing property; all good will relating to the foregoing property; all records and data and embedded software relating to the foregoing property, and all equipment, inventory and software to utilize, create, maintain and process
any such records and data on electronic media; and all supporting obligations relating to the foregoing property; all whether now existing or hereafter arising, whether now owned or hereafter acquired or whether now or hereafter subject to any
rights in the foregoing property; and all products and proceeds (including but not limited to all insurance payments) of or relating to the foregoing property. 

DESCRIPTION OF CHANGE IN TERMS. 
  

	1.	The maturity date is hereby extended from August 31, 2010 to June 30, 2012. 

 

	2.	The Letter of Credit Subline is hereby amended as described in the attached “Letter of Credit Subline Exhibit” 

 

	3.	The Foreign Exchange Subline is hereby amended as described in the attached “Foreign Exchange Subline Exhibit”. 

 

	4.	The Commercial Guaranty executed by IRIS Molecular Diagnostics, Inc. in the amount of $16,500,000.00, is hereby added to the Loan. 

 

	5.	The following collateral is hereby added to the loan for IRIS Molecular Diagnostics, Inc.: 

All inventory, equipment, accounts (including but not limited to all health-care-insurance receivables), chattel paper, instruments
(including but not limited to all promissory notes), letter-of-credit rights, letters of credit, documents, deposit accounts, investment property, money, other rights to payment and performance, and general intangibles (including but not limited to
all software and all payment intangibles); all fixtures; all attachments, accessions, accessories, fittings, increases, tools, parts, repairs, supplies, and commingled goods relating to the foregoing property, and all additions, replacements of and
substitutions for all or any part of the foregoing property; all insurance refunds relating to the foregoing property; all good will relating to the foregoing property; all records and data and embedded software relating to the foregoing property,
and all equipment, inventory and software to utilize, create, maintain and process any such records and data on electronic media; and all supporting obligations relating to the foregoing property; all whether now existing or hereafter arising,
whether now owned or hereafter acquired or whether now or hereafter subject to any rights in the foregoing property; and all products and proceeds (including but not limited to all insurance payments) of or relating to the foregoing property.

 All other terms and conditions shall remain the same. 

CONTINUING VALIDITY. Except as expressly changed by this Agreement, the terms of the original obligation or obligations, including all agreements
evidenced or securing the obligation(s), remain unchanged and in full force and effect. Consent by Lender to this Agreement does not waive Lender’s right to strict performance of the obligation(s) as changed, nor obligate Lender to make any
future change in terms. Nothing in this Agreement will constitute a satisfaction of the obligation(s). It is the intention of Lender to retain as liable parties all makers and endorsers of the original obligation(s), including accommodation parties,
unless a party is expressly released by Lender in writing. Any maker or endorser, including accommodation makers, will not be released by virtue of this Agreement. If any person who signed the original obligation does not sign this Agreement below,
then all persons signing below acknowledge that this Agreement is given conditionally, based on the representation to Lender that the non-signing party consents to the changes and provisions of this Agreement or otherwise will not be released by it.
This waiver applies not only to any initial extension, modification or release, but also to all such subsequent actions. 
 FINANCIAL
STATEMENT CERTIFICATIONS. The undersigned hereby certifies to California Bank & Trust (“Bank”) that all financial information (“Information”) submitted to Bank now and at all times during the terms of this loan does,
and will, fairly and accurately represent the financial condition of the undersigned, all Borrowers and Guarantors. Financial Information includes, but is not limited to all Business Financial Statements (including Interim and Year-End financial
statements that are company prepared and/or CPA-prepared), Business Income Tax Returns, Borrowing Base Certificates, Accounts Receivable and Accounts Payable Agings, Personal Financial Statements and Personal Income Tax Returns. The undersigned
understands that the Bank will rely on all financial information, whenever provided, and that such information is a material inducement to Bank to make, to continue to make, or otherwise extend credit accommodations to the undersigned. The
undersigned covenants and agrees to notify Bank of any adverse material changes in her/his/its financial condition in the future. The undersigned further understands and acknowledges that there are criminal penalties for giving false financial
information to federally insured financial institutions. 

 DEPOSIT ACCOUNT SECURITY. Borrower hereby grants a security interest to Lender in any and all deposit
accounts (checking, savings, money market or time) of Borrower at Lender, now existing or hereinafter opened, to secure its Indebtedness hereunder. This includes all deposit accounts Borrower holds jointly with someone else. 

LETTER OF CREDIT SUBLINE EXHIBIT. An exhibit, titled “Letter of Credit Subline Exhibit,” is attached to this Agreement and by this
reference is made a part of this Agreement just as if all the provisions, terms and conditions of the Exhibit had been fully set forth in this Agreement. 

FOREIGN EXCHANGE SUBLINE EXHIBIT. An exhibit, titled “Foreign Exchange Subline Exhibit,” is attached to this Agreement and by this
reference is made a part of this Agreement just as if all the provisions, terms and conditions of the Exhibit had been fully set forth in this Agreement. 

PRIOR TO SIGNING THIS AGREEMENT, BORROWER READ AND UNDERSTOOD ALL THE PROVISIONS OF THIS AGREEMENT. BORROWER AGREES TO THE TERMS OF THE AGREEMENT.

 BORROWER: 
  

							
	IRIS INTERNATIONAL, INC.	 	 	 	 
				
	 By:
	 	 /s/ Cesar Garcia
	 	By:	 	 /s/ Martin McDermut

		 	Cesar Garcia, President/CEO of IRIS International, Inc.	 		 	Martin McDermut, CFO of IRIS International, Inc.

LASER PRO Lending, Ver. 5.52.20.003 Copr. Harland Financial Solutions, Inc. 1997, 2010. All Rights Reserved. - CA L:\CFI\LPL\D20C.FC
TR-35266 PR-1 (M) 

 LETTER OF CREDIT SUBLINE EXHIBIT 

 

															
	 Principal
	 	 Loan Date
	 	 Maturity
	  	Loan No	  	Call / Coll	  	Account	  	Officer	  	Initials
	$6,500,000.00	 	08-31-2010	 	06-30-2012	  	0083976-0001	  		  	0083976-0001	  	07738	  	

 References in the boxes above are for Lender’s use only and do not limit the applicability of
this document to any particular loan or item. 
 Any item above containing “***” has been omitted due to text length
limitations. 
  

							
	Borrower:	  	 IRIS International, Inc.

9172 Eton Avenue
 Chatsworth, CA
91311
	  	Lender:	  	 California Bank & Trust

Los Angeles Commercial Banking
 550
South Hope Street, Suite 300
 Los Angeles, CA 90071

This LETTER OF CREDIT SUBLINE EXHIBIT is attached to and by this reference is made a part of the Change In Terms Agreement, dated August 31,
2010, and executed in connection with a loan or other financial accommodations between CALIFORNIA BANK & TRUST and IRIS International, Inc. 

Letter of Credit Subline. The Line of Credit includes a subline facility for commercial letters of credit (each a “Letter of Credit”
and collectively the “Letters of Credit”) for the account of Borrower (the “Letter of Credit Subline”). Provided there is no Event of Default and subject to the terms and conditions of the Agreement, Borrower may obtain Letters
of Credit on a revolving basis. This Letter of Credit Subline may be used for obtaining Letters of Credit with a maximum expiration date of June 30, 2012. No new Letters of Credit can be issued after the Line of Credit matures on
June 30, 2012. 
 a. The amount of all issued, outstanding and unexpired Letters of Credit, including amounts drawn on Letters of
Credit and not yet reimbursed by Borrower to Lender, may not exceed 1,000,000.00. 
 b. The amount of all issued, outstanding and
unexpired Letters of Credit and Foreign Exchange Subline, including amounts drawn on Letters of Credit and Foreign Exchange Subline and not yet reimbursed to Lender, together with all amounts outstanding on the Line of Credit, shall
not exceed Six Million FIve Hundred Thousand and no/100 Dollars ($6,500,000.00). 
 c. Any sum drawn under a Letter of Credit
shall be either immediately reimbursed to Lender by Borrower or added by Lender to the principal amount outstanding under the Line of Credit and shall be governed by the terms and conditions regarding the Line of Credit set forth in this Agreement.
Any sum drawn under a Letter of Credit after the maturity of the Line of Credit, or after the occurrence of an Event of Default, shall be due with interest on demand and shall accrue interest at the default rate of interest as provided in the
Agreement. 
 d. In the event any Letters of Credit are outstanding on June 30, 2012, or upon the occurrence of an Event of Default,
Borrower shall immediately provide Lender with a written request for cancellation of the Letter of Credit from the beneficiary’s bank in form acceptable to Lender, or deposit with Lender, as cash collateral for the obligations of Borrower to
reimburse Lender for draws under such remaining outstanding Letters of Credit, an amount equal to the face amount of all such outstanding Letters of Credit to be applied to repay draws under such Letters of Credit as and when made. Borrower hereby
grants to Lender a security interest in such cash collateral. 
 e. The issuance of any Letter of Credit or any amendment to a Letter of Credit
is subject to Lender’s written approval and such Letter of Credit, or any amendment thereto, must be in form and content satisfactory to Lender and in favor of a beneficiary acceptable to Lender. Borrower will complete with proper insertions,
sign and deliver to Lender, Lender’s application and agreement for each requested Letter of Credit. Lender may refuse to issue a Letter of Credit or amendment to any Letter of Credit due to the nature or terms of the transaction for which the
Letter of Credit is required or when applicable law, regulation or order prohibits the issuance of the Letter of Credit or amendment. 
 f. The
obligations of Borrower under each Letter of Credit issued by Lender are secured by a security interest granted by Borrower in the goods (as defined in the Uniform Commercial Code) included in the Letter of Credit transaction. 

g. Borrower agrees that Lender may automatically charge Borrower’s deposit accounts with Lender for applicable fees, discounts, and other charges
relating to any Letters of Credit, as well as for any reimbursement obligation hereunder, an Borrower hereby grants a security interest to Lender in such accounts for such purposes. 

h. Borrower will pay promptly Lender’s issuance, settlement and other fees (in accordance with the prevailing California Bank & Trust
Transaction Fee Schedule as issued from time to time or such other current Lender publication) for Letters of Credit and all expenses incurred by Lender in connection therewith. 

i. Lender shall have no obligation to enter a Commercial Letter of Credit if there is an uncured breach of Event of Default by Borrower under this
Agreement, any Commercial Letter of Credit or any other obligation of Borrower to Lender. 

 THIS LETTER OF CREDIT SUBLINE EXHIBIT IS EXECUTED ON AUGUST 31, 2010. 

BORROWER: 
 IRIS INTERNATIONAL, INC.

  

			
	By:	 	 /s/ Cesar Garcia

	Cesar Garcia, President/CEO of IRIS International, Inc.
		
	By:	 	 /s/ Martin McDermut

	Martin McDermut, CFO of IRIS International, Inc.

 LASER PRO Lending, Ver. 5.52.20.003 Copr. Harland Financial Solutions, Inc. 1997, 2010. All Rights Reserved. - CA
L:\CFI\LPL\D20C.FC TR-35266 PR-1 (M) 

 FOREIGN EXCHANGE SUBLINE EXHIBIT 

 

															
	 Principal
	 	 Loan Date
	 	 Maturity
	  	Loan No	  	Call / Coll	  	Account	  	Officer	  	Initials
	$6,500,000.00	 	08-31-2010	 	06-30-2012	  	0083976-0001	  		  	0083976-0001	  	07738	  	

 References in the boxes above are for Lender’s use only and do not limit the applicability of
this document to any particular loan or item. 
 Any item above containing “***” has been omitted due to text length
limitations. 
  

							
	Borrower:	  	 IRIS International, Inc.

9172 Eton Avenue
 Chatsworth, CA
91311
	  	Lender:	  	 California Bank & Trust

Los Angeles Commercial Banking
 550
South Hope Street, Suite 300
 Los Angeles, CA 90071

This FOREIGN EXCHANGE SUBLINE EXHIBIT is attached to and by this reference is made a part of the Change In Terms Agreement, dated August 31,
2010, and executed in connection with a loan or other financial accommodations between CALIFORNIA BANK & TRUST and IRIS International, Inc. 

Foreign Exchange Subline. The Line of Credit includes a subline facility for foreign exchange contracts to be entered by Borrower and Lender in
form and substance acceptable to Lender (each a “Foreign Exchange Contract” and collectively the “Foreign Exchange Contracts”) for the account of Borrower (“Foreign Exchange Subline”). Subject to the terms and
conditions of the Agreement, Borrower may enter Foreign Exchange Contracts with Lender on a revolving basis, for the exchange of currencies (each an “Exchange Transaction” and, collectively, “Exchange Transactions”). 

a. Each Exchange Transaction will be governed by the the terms and conditions set forth in this Agreement and in a written Foreign Exchange Contract to
be executed by the parties which shall set forth the date of exchange, the currencies to be exchanged and their amount. Each Foreign Exchange Contract constitutes a supplement to and forms a part of this Agreement. 

b. The aggregate U.S. dollars amount of all outstanding Exchange Transactions, as determined by Lender shall not exceed Three Million and no/100
Dollars ($3,000,000.00). 
 c. The aggregate U.S. dollar amount of all pending and unexpired Exchange Transactions as determined by
Lender, plus the amount of all issued, outstanding and unexpired Letters of Credit, Acceptances and Letters of Undertaking, including amount drawn on Letters of Credit, acceptances, Letters of Undertaking and Exchange Transactions and not yet
reimbursed, together with all other amounts outstanding under the Line of Credit shall not exceed Six Million Five Hundred Thousand and no/100 Dollars ($6,500,000.00). 

d. No Foreign Exchange Contract shall be entered after June 30, 2012. No Foreign Exchange Contract shall have a date of exchange, or
currency delivery date, of later than June 30, 2012. 
 e. Lender shall have no obligation to enter a Foreign Exchange
Contract if there is an uncured breach of Event of Default by Borrower under this Agreement, any Foreign Exchange Contract or any other obligation of Borrower to Lender. 

g. Borrower agrees that Lender may automatically charge Borrower’s deposit accounts with Lender for applicable fees, discounts, and other charges
relating to any Foreign Exchange Contract, as well as for any reimbursement obligation hereunder, and Borrower hereby grants a security interest to Lender in such accounts for such purposes. 

THIS FOREIGN EXCHANGE SUBLINE EXHIBIT IS EXECUTED ON AUGUST 31, 2010. 

BORROWER: 
  

			
	IRIS INTERNATIONAL, INC.
		
	By:	 	 /s/ Cesar Garcia

		 	Cesar Garcia, President/CEO of IRIS International, Inc.
		
	By:	 	 /s/ Martin McDermut

		 	Martin McDermut, CFO of IRIS International, Inc.

LASER PRO Lending, Ver. 5.52.20.003 Copr. Harland Financial Solutions, Inc. 1997, 2010. All Rights Reserved. - CA L:\CFI\LPL\D20C.FC
TR-35266 PR-1 (M)Commercial Guaranty

 Exhibit 10.2 

COMMERCIAL GUARANTY 
  

															
	 Principal
	 	 Loan Date
	 	 Maturity
	  	Loan No	  	Call / Coll	  	Account	  	Officer	  	Initials
		 		 		  		  		  		  	07738	  	

 References in the boxes above are for Lender’s use only and do not limit the applicability of
this document to any particular loan or item. 
 Any item above containing “***” has been omitted due to text length
limitations. 
  

							
	Borrower:	  	 IRIS International, Inc.

9172 Eton Avenue
 Chatsworth, CA
91311-5805
	  	Lender:	  	 California Bank & Trust

Los Angeles Commercial Banking
 550
South Hope Street, Suite 300
 Los Angeles, CA 90071

				
	Guarantor:	  	 IRIS Molecular Diagnostics, Inc.

160 Greentree Drive, Suite 101
 Dover,
DE 19904
	  		  	

 CONTINUING GUARANTEE OF PAYMENT AND PERFORMANCE. For good and valuable consideration, Guarantor absolutely
and unconditionally guarantees full and punctual payment and satisfaction of Guarantor’s Share of the Indebtedness of Borrower to Lender, and the performance and discharge of all Borrower’s obligations under the Note and the Related
Documents. This is a guaranty of payment and performance and not of collection, so Lender can enforce this Guaranty against Guarantor even when Lender has not exhausted Lender’s remedies against anyone else obligated to pay the Indebtedness or
against any collateral securing the Indebtedness, this Guaranty or any other guaranty of the Indebtedness. Guarantor will make any payments to Lender or its order, on demand, in legal tender of the United States of America, in same-day funds,
without set-off or deduction or counterclaim, and will otherwise perform Borrower’s obligations under the Note and Related Documents. Under this Guaranty, Guarantor’s obligations are continuing. 

INDEBTEDNESS. The word “Indebtedness” as used in this Guaranty means all of the principal amount outstanding from time to time and at
any one or more times, accrued unpaid interest thereon and all collection costs and legal expenses related thereto permitted by law, attorneys’ fees, arising from any and all debts, liabilities and obligations of every nature or form, now
existing or hereafter arising or acquired, that Borrower individually or collectively or interchangeably with others, owes or will owe Lender. “Indebtedness” includes, without limitation, loans, advances, debts, overdraft indebtedness,
credit card indebtedness, lease obligations, liabilities and obligations under any interest rate protection agreements or foreign currency exchange agreements or commodity price protection agreements, other obligations, and liabilities of Borrower,
and any present or future judgments against Borrower, future advances, loans or transactions that renew, extend, modify, refinance, consolidate or substitute these debts, liabilities and obligations whether: voluntarily or involuntarily incurred;
due or to become due by their terms or acceleration; absolute or contingent; liquidated or unliquidated; determined or undetermined; direct or indirect; primary or secondary in nature or arising from a guaranty or surety; secured or unsecured; joint
or several or joint and several; evidenced by a negotiable or non-negotiable instrument or writing; originated by Lender or another or others; barred or unenforceable against Borrower for any reason whatsoever; for any transactions that may be
voidable for any reason (such as infancy, insanity, ultra vires or otherwise); and originated then reduced or extinguished and then afterwards increased or reinstated. 

If Lender presently holds one or more guaranties, or hereafter receives additional guaranties from Guarantor, Lender’s rights under all guaranties
shall be cumulative. This Guaranty shall not (unless specifically provided below to the contrary) affect or invalidate any such other guaranties. Guarantor’s liability will be Guarantor’s aggregate liability under the terms of this
Guaranty and any such other unterminated guaranties. 
 GUARANTOR’S SHARE OF THE INDEBTEDNESS. The words “Guarantor’s
Share of the Indebtedness” as used in this Guaranty mean an amount not to exceed Sixteen Million Five Hundred Thousand & 00/100 Dollars ($16,500,000.00) of all the principal amount, interest thereon to the extent not prohibited by law,
and all collection costs, expenses and attorneys’ fees whether or not there is a lawsuit, and if there is a lawsuit, any fees and costs for trial and appeals. 

Guarantor’s Share of the Indebtedness will only be reduced by sums actually paid by Guarantor under this Guaranty, but will not be reduced by sums
from any other source including, but not limited to, sums realized from any collateral securing the Indebtedness or this Guaranty, or payments by anyone other than Guarantor, or reductions by operation of law, judicial order or equitable principles.
Lender has the sole and absolute discretion to determine how sums shall be applied among guaranties of the Indebtedness. 
 The above limitation
on liability is not a restriction on the amount of the Note of Borrower to Lender either in the aggregate or at any one time. 
 CONTINUING
GUARANTY. THIS IS A “CONTINUING GUARANTY” UNDER WHICH GUARANTOR AGREES TO GUARANTEE THE FULL AND PUNCTUAL PAYMENT, PERFORMANCE AND SATISFACTION OF THE GUARANTOR’S SHARE OF THE INDEBTEDNESS OF BORROWER TO LENDER, NOW EXISTING OR
HEREAFTER ARISING OR ACQUIRED, ON A CONTINUING BASIS. ACCORDINGLY, ANY PAYMENTS MADE ON THE INDEBTEDNESS WILL NOT DISCHARGE OR DIMINISH GUARANTOR’S OBLIGATIONS AND LIABILITY UNDER THIS GUARANTY FOR ANY REMAINING AND SUCCEEDING INDEBTEDNESS EVEN
WHEN ALL OR PART OF THE OUTSTANDING INDEBTEDNESS MAY BE A ZERO BALANCE FROM TIME TO TIME. 
 DURATION OF GUARANTY. This Guaranty will
take effect when received by Lender without the necessity of any acceptance by Lender, or any notice to Guarantor or to Borrower, and will continue in full force until all the Indebtedness incurred or contracted before receipt by Lender of any
notice of revocation shall have been fully and finally paid and satisfied and all of Guarantor’s other obligations under this Guaranty shall have been performed in full. If Guarantor elects to revoke this Guaranty, Guarantor may only do so in
writing. Guarantor’s written notice of revocation must be mailed to Lender, by certified mail, at Lender’s address listed above or such other place as Lender may designate in writing. Written revocation of this Guaranty will apply only to
new Indebtedness created after actual receipt by Lender of Guarantor’s written revocation. For this purpose and without limitation, the term “new Indebtedness” does not include the Indebtedness which at the time of notice of
revocation is contingent, unliquidated, undetermined or not due and which later becomes absolute, liquidated, determined or due. For this purpose and without limitation, “new Indebtedness” does not include all or part of the Indebtedness
that is: incurred by Borrower prior to revocation; incurred under a commitment that became binding before revocation; any renewals, 

 
extensions, substitutions, and modifications of the Indebtedness. This Guaranty shall bind Guarantor’s estate as to the Indebtedness created both before and after Guarantor’s death or
incapacity, regardless of Lender’s actual notice of Guarantor’s death. Subject to the foregoing, Guarantor’s executor or administrator or other legal representative may terminate this Guaranty in the same manner in which Guarantor
might have terminated it and with the same effect. Release of any other guarantor or termination of any other guaranty of the Indebtedness shall not affect the liability of Guarantor under this Guaranty. A revocation Lender receives from any one or
more Guarantors shall not affect the liability of any remaining Guarantors under this Guaranty. It is anticipated that fluctuations may occur in the aggregate amount of the Indebtedness covered by this Guaranty, and Guarantor specifically
acknowledges and agrees that reductions in the amount of the Indebtedness, even to zero dollars ($0.00), shall not constitute a termination of this Guaranty. This Guaranty is binding upon Guarantor and Guarantor’s heirs, successors and assigns
so long as any of the Guarantor’s Share of the Indebtedness remains unpaid and even though the Guarantor’s Share of the Indebtedness may from time to time be zero dollars ($0.00). 

GUARANTOR’S AUTHORIZATION TO LENDER. Guarantor authorizes Lender, either before or after any revocation hereof, without notice or demand
and without lessening Guarantor’s liability under this Guaranty, from time to time: (A) prior to revocation as set forth above, to make one or more additional secured or unsecured loans to Borrower, to lease equipment or other goods to
Borrower, or otherwise to extend additional credit to Borrower; (B) to alter, compromise, renew, extend, accelerate, or otherwise change one or more times the time for payment or other terms of the Indebtedness or any part of the Indebtedness,
including increases and decreases of the rate of interest on the Indebtedness; extensions may be repeated and may be for longer than the original loan term; (C) to take and hold security for the payment of this Guaranty or the Indebtedness, and
exchange, enforce, waive, subordinate, fail or decide not to perfect, and release any such security, with or without the substitution of new collateral; (D) to release, substitute, agree not to sue, or deal with any one or more of
Borrower’s sureties, endorsers, or other guarantors on any terms or in any manner Lender may choose; (E) to determine how, when and what application of payments and credits shall be made on the Indebtedness; (F) to apply such security
and direct the order or manner of sale thereof, including without limitation, any nonjudicial sale permitted by the terms of the controlling security agreement or deed of trust, as Lender in its discretion may determine; (G) to sell, transfer,
assign or grant participations in all or any part of the Indebtedness; and (H) to assign or transfer this Guaranty in whole or in part. 

GUARANTOR’S REPRESENTATIONS AND WARRANTIES. Guarantor represents and warrants to Lender that (A) no representations or agreements of any
kind have been made to Guarantor which would limit or qualify in any way the terms of this Guaranty; (B) this Guaranty is executed at Borrower’s request and not at the request of Lender; (C) Guarantor has full power, right and
authority to enter into this Guaranty; (D) the provisions of this Guaranty do not conflict with or result in a default under any agreement or other instrument binding upon Guarantor and do not result in a violation of any law, regulation, court
decree or order applicable to Guarantor; (E) Guarantor has not and will not, without the prior written consent of Lender, sell, lease, assign, encumber, hypothecate, transfer, or otherwise dispose of all or substantially all of Guarantor’s
assets, or any interest therein; (F) upon Lender’s request, Guarantor will provide to Lender financial and credit information in form acceptable to Lender, and all such financial information which currently has been, and all future
financial information which will be provided to Lender is and will be true and correct in all material respects and fairly present Guarantor’s financial condition as of the dates the financial information is provided; (G) no material
adverse change has occurred in Guarantor’s financial condition since the date of the most recent financial statements provided to Lender and no event has occurred which may materially adversely affect Guarantor’s financial condition;
(H) no litigation, claim, investigation, administrative proceeding or similar action (including those for unpaid taxes) against Guarantor is pending or threatened; (I) Lender has made no representation to Guarantor as to the
creditworthiness of Borrower; and (J) Guarantor has established adequate means of obtaining from Borrower on a continuing basis information regarding Borrower’s financial condition. Guarantor agrees to keep adequately informed from such
means of any facts, events, or circumstances which might in any way affect Guarantor’s risks under this Guaranty, and Guarantor further agrees that, absent a request for information, Lender shall have no obligation to disclose to Guarantor any
information or documents acquired by Lender in the course of its relationship with Borrower. 
 GUARANTOR’S WAIVERS. Except as
prohibited by applicable law, Guarantor waives any right to require Lender to (A) make any presentment, protest, demand, or notice of any kind, including notice of change of any terms of repayment of the Indebtedness, default by Borrower or any
other guarantor or surety, any action or nonaction taken by Borrower, Lender, or any other guarantor or surety of Borrower, or the creation of new or additional Indebtedness; (B) proceed against any person, including Borrower, before proceeding
against Guarantor; (C) proceed against any collateral for the Indebtedness, including Borrower’s collateral, before proceeding against Guarantor; (D) apply any payments or proceeds received against the Indebtedness in any order;
(E) give notice of the terms, time, and place of any sale of the collateral pursuant to the Uniform Commercial Code or any other law governing such sale; (F) disclose any information about the Indebtedness, the Borrower, the collateral, or
any other guarantor or surety, or about any action or nonaction of Lender; or (G) pursue any remedy or course of action in Lender’s power whatsoever. 

Guarantor also waives any and all rights or defenses arising by reason of (H) any disability or other defense of Borrower, any other guarantor or
surety or any other person; (I) the cessation from any cause whatsoever, other than payment in full, of the Indebtedness; (J) the application of proceeds of the Indebtedness by Borrower for purposes other than the purposes understood and
intended by Guarantor and Lender; (K) any act of omission or commission by Lender which directly or indirectly results in or contributes to the discharge of Borrower or any other guarantor or surety, or the Indebtedness, or the loss or release
of any collateral by operation of law or otherwise; (L) any statute of limitations in any action under this Guaranty or on the Indebtedness; or (M) any modification or change in terms of the Indebtedness, whatsoever, including without
limitation, the renewal, extension, acceleration, or other change in the time payment of the Indebtedness is due and any change in the interest rate, and including any such modification or change in terms after revocation of this Guaranty on the
Indebtedness incurred prior to such revocation. 
 Guarantor waives all rights of subrogation, reimbursement, indemnification, and contribution
and any other rights and defenses that are or may become available to Guarantor by reason of California Civil Code Sections 2787 to 2855, inclusive. 

Guarantor waives all rights and any defenses arising out of an election of remedies by Lender even though that the election of remedies, such as a
non-judicial foreclosure with respect to security for a guaranteed obligation, has destroyed Guarantor’s rights of subrogation and reimbursement against Borrower by operation of Section 580d of the California Code of Civil Procedure or
otherwise. 
 Guarantor waives all rights and defenses that Guarantor may have because Borrower’s obligation is secured by real property.
This means among other things: (N) Lender may collect from Guarantor without first foreclosing on any real or personal property collateral pledged by Borrower. (O) If Lender forecloses on any real property collateral pledged by Borrower:
(1) the amount of Borrower’s obligation may be reduced only by the price for which the collateral is sold at the foreclosure sale, even if the collateral is worth more than the sale price. (2) Lender may collect from Guarantor even if
Lender, by foreclosing on the real property collateral, has destroyed any right Guarantor may have to collect from Borrower. This is an unconditional and irrevocable waiver of any rights and defenses Guarantor may have because Borrower’s
obligation is secured by real property. These rights and defenses include, but are not limited to, any rights and defenses based upon Section 580a, 580b, 580d, or 726 of the Code of Civil Procedure. 

 Guarantor understands and agrees that the foregoing waivers are unconditional and irrevocable waivers of
substantive rights and defenses to which Guarantor might otherwise be entitled under state and federal law. The rights and defenses waived include, without limitation, those provided by California laws of suretyship and guaranty, anti-deficiency
laws, and the Uniform Commercial Code. Guarantor acknowledges that Guarantor has provided these waivers of rights and defenses with the intention that they be fully relied upon by Lender. Guarantor further understands and agrees that this Guaranty
is a separate and independent contract between Guarantor and Lender, given for full and ample consideration, and is enforceable on its own terms. Until all of the Indebtedness is paid in full, Guarantor waives any right to enforce any remedy
Guarantor may have against the Borrower or any other guarantor, surety, or other person, and further, Guarantor waives any right to participate in any collateral for the Indebtedness now or hereafter held by Lender. 

Guarantor’s Understanding With Respect To Waivers. Guarantor warrants and agrees that each of the waivers set forth above is made with
Guarantor’s full knowledge of its significance and consequences and that, under the circumstances, the waivers are reasonable and not contrary to public policy or law. If any such waiver is determined to be contrary to any applicable law or
public policy, such waiver shall be effective only to the extent permitted by law or public policy. 
 Subordination of Borrower’s Debts
to Guarantor. Guarantor agrees that the Indebtedness, whether now existing or hereafter created, shall be superior to any claim that Guarantor may now have or hereafter acquire against Borrower, whether or not Borrower becomes insolvent.
Guarantor hereby expressly subordinates any claim Guarantor may have against Borrower, upon any account whatsoever, to any claim that Lender may now or hereafter have against Borrower. In the event of insolvency and consequent liquidation of the
assets of Borrower, through bankruptcy, by an assignment for the benefit of creditors, by voluntary liquidation, or otherwise, the assets of Borrower applicable to the payment of the claims of both Lender and Guarantor shall be paid to Lender and
shall be first applied by Lender to the Indebtedness. Guarantor does hereby assign to Lender all claims which it may have or acquire against Borrower or against any assignee or trustee in bankruptcy of Borrower; provided however, that such
assignment shall be effective only for the purpose of assuring to Lender full payment in legal tender of the Indebtedness. If Lender so requests, any notes or credit agreements now or hereafter evidencing any debts or obligations of Borrower to
Guarantor shall be marked with a legend that the same are subject to this Guaranty and shall be delivered to Lender. Guarantor agrees, and Lender is hereby authorized, in the name of Guarantor, from time to time to file financing statements and
continuation statements and to execute documents and to take such other actions as Lender deems necessary or appropriate to perfect, preserve and enforce its rights under this Guaranty. 

Miscellaneous Provisions. The following miscellaneous provisions are a part of this Guaranty: 

AMENDMENTS. This Guaranty, together with any Related Documents, constitutes the entire understanding and agreement of the parties as to the
matters set forth in this Guaranty. No alteration of or amendment to this Guaranty shall be effective unless given in writing and signed by the party or parties sought to be charged or bound by the alteration or amendment. 

ATTORNEYS’ FEES; EXPENSES. Guarantor agrees to pay upon demand all of Lender’s costs and expenses, including Lender’s
attorneys’ fees and Lender’s legal expenses, incurred in connection with the enforcement of this Guaranty. Lender may hire or pay someone else to help enforce this Guaranty, and Guarantor shall pay the costs and expenses of such
enforcement. Costs and expenses include Lender’s attorneys’ fees and legal expenses whether or not there is a lawsuit, including attorneys’ fees and legal expenses for bankruptcy proceedings (including efforts to modify or vacate any
automatic stay or injunction), appeals, and any anticipated post-judgment collection services. Guarantor also shall pay all court costs and such additional fees as may be directed by the court. 

CAPTION HEADINGS. Caption headings in this Guaranty are for convenience purposes only and are not to be used to interpret or define the provisions
of this Guaranty. 
 GOVERNING LAW. This Guaranty will be governed by federal law applicable to Lender and, to the extent not preempted by
federal law, the laws of the State of California without regard to its conflicts of law provisions. 
 CHOICE OF VENUE. If there is a
lawsuit, Guarantor agrees upon Lender’s request to submit to the jurisdiction of the courts of Los Angeles County, State of California. 

INTEGRATION. Guarantor further agrees that Guarantor has read and fully understands the terms of this Guaranty; Guarantor has had the opportunity
to be advised by Guarantor’s attorney with respect to this Guaranty; the Guaranty fully reflects Guarantor’s intentions and parol evidence is not required to interpret the terms of this Guaranty. Guarantor hereby indemnifies and holds
Lender harmless from all losses, claims, damages, and costs (including Lender’s attorneys’ fees) suffered or incurred by Lender as a result of any breach by Guarantor of the warranties, representations and agreements of this paragraph.

 INTERPRETATION. In all cases where there is more than one Borrower or Guarantor, then all words used in this Guaranty in the singular
shall be deemed to have been used in the plural where the context and construction so require; and where there is more than one Borrower named in this Guaranty or when this Guaranty is executed by more than one Guarantor, the words
“Borrower” and “Guarantor” respectively shall mean all and any one or more of them. The words “Guarantor,” “Borrower,” and “Lender” include the heirs, successors, assigns, and transferees of each of
them. If a court finds that any provision of this Guaranty is not valid or should not be enforced, that fact by itself will not mean that the rest of this Guaranty will not be valid or enforced. Therefore, a court will enforce the rest of the
provisions of this Guaranty even if a provision of this Guaranty may be found to be invalid or unenforceable. If any one or more of Borrower or Guarantor are corporations, partnerships, limited liability companies, or similar entities, it is not
necessary for Lender to inquire into the powers of Borrower or Guarantor or of the officers, directors, partners, managers, or other agents acting or purporting to act on their behalf, and any indebtedness made or created in reliance upon the
professed exercise of such powers shall be guaranteed under this Guaranty. 
 NOTICES. Any notice required to be given under this
Guaranty shall be given in writing, and, except for revocation notices by Guarantor, shall be effective when actually delivered, when actually received by telefacsimile (unless otherwise required by law), when deposited with a nationally recognized
overnight courier, or, if mailed, when deposited in the United States mail, as first class, certified or registered mail postage prepaid, directed to the addresses shown near the beginning of this Guaranty. All revocation notices by Guarantor shall
be in writing and shall be effective upon delivery to Lender as provided in the section of this Guaranty entitled “DURATION OF GUARANTY.” Any party may change its address for notices under this Guaranty by giving formal written notice to
the other parties, specifying that the purpose of the notice is to change the party’s address. For notice purposes, Guarantor agrees to keep Lender informed at all times of Guarantor’s current address. Unless otherwise provided or required
by law, if there is more than one Guarantor, any notice given by Lender to any Guarantor is deemed to be notice given to all Guarantors. 

NO WAIVER BY LENDER. Lender shall not be deemed to have waived any rights under this Guaranty unless such waiver is given in writing and signed by
Lender. No delay or omission on the part of Lender in exercising any right shall operate as a waiver of such right or any other right. A waiver by Lender of a provision of this Guaranty shall not prejudice or constitute a waiver of Lender’s
right otherwise to demand strict compliance with that provision or 

 
any other provision of this Guaranty. No prior waiver by Lender, nor any course of dealing between Lender and Guarantor, shall constitute a waiver of any of Lender’s rights or of any of
Guarantor’s obligations as to any future transactions. Whenever the consent of Lender is required under this Guaranty, the granting of such consent by Lender in any instance shall not constitute continuing consent to subsequent instances where
such consent is required and in all cases such consent may be granted or withheld in the sole discretion of Lender. 
 SUCCESSORS AND
ASSIGNS. Subject to any limitations stated in this Guaranty on transfer of Guarantor’s interest, this Guaranty shall be binding upon and inure to the benefit of the parties, their successors and assigns. 

FINANCIAL STATEMENT CERTIFICATIONS. The undersigned hereby certifies to California Bank & Trust (“Bank”) that all financial
information (“Information”) submitted to Bank now and at all times during the terms of this loan does, and will, fairly and accurately represent the financial condition of the undersigned, all Borrowers and Guarantors. Financial
Information includes, but is not limited to all Business Financial Statements (including Interim and Year-End financial statements that are company prepared and/or CPA-prepared), Business Income Tax Returns, Borrowing Base Certificates, Accounts
Receivable and Accounts Payable Agings, Personal Financial Statements and Personal Income Tax Returns. The undersigned understands that the Bank will rely on all financial information, whenever provided, and that such information is a material
inducement to Bank to make, to continue to make, or otherwise extend credit accommodations to the undersigned. The undersigned covenants and agrees to notify Bank of any adverse material changes in her/his/its financial condition in the future. The
undersigned further understands and acknowledges that there are criminal penalties for giving false financial information to federally insured financial institutions. 

DEPOSIT ACCOUNT SECURITY. Guarantor hereby grants a security interest to Lender in any and all deposit accounts (checking, savings, money market
or time) of Guarantor at Lender, now existing or hereinafter opened, to secure its obligations hereunder. This includes all deposit accounts Guarantor holds jointly with someone else. 

JURY WAIVER; JUDICIAL REFERENCE. Each of the parties hereto waives his, her or its respective rights to a trial before a jury in connection with
any disputes related to this Guaranty, any of the Related Documents and the transactions contemplated hereby and thereby. Such disputes include without limitation any claims by a party, claims brought by Borrower or Guarantor as a class
representative on behalf of others and claims by a class representative on Borrower’s or Guarantor’s behalf as a class member (so-called “class action” suits). This provision shall not apply if, at the time an action is brought,
this Guaranty is entered into in a state where this jury trial waiver is not permitted by law. 
 If a jury trial waiver is not permitted by
applicable law and a dispute arises between or among any of the parties hereto with respect to this Guaranty, any of the Related Documents, the enforcement hereof or thereof or the transactions contemplated hereby or thereby, any party to such
dispute may require that it be resolved by judicial reference in accordance with California Code of Civil Procedure, Sections 638, et seq., including without limitation whether the dispute is subject to a judicial reference proceeding. The referee
shall be a retired judge, agreed upon by the parties, from either the American Arbitration Association (AAA) or Judicial Arbitration and Mediation Service, Inc. (JAMS). If the parties cannot agree on the referee, the party who initially selected the
reference procedure shall request a panel of ten retired judges from either AAA or JAMS, and the court shall select the referee from that panel. The referee shall be appointed to sit with all of the powers provided by law. The parties agree that
time is of the essence in conducting the judicial reference proceeding set forth herein. The costs of the judicial reference proceeding, including the fee for the court reporter, shall be borne equally by the parties involved in the dispute as the
costs are incurred, unless otherwise awarded by the referee. The referee shall hear all pre-trial and post-trial matters (including without limitation requests for equitable relief), prepare an award with written findings of fact and conclusions of
law and apportion costs as appropriate. The referee shall be empowered to enter equitable relief as well as legal relief, provide all temporary or provisional remedies, enter equitable orders that are binding on the parties and rule on any motion
that would be authorized in a trial, including without limitation motions for summary judgment or summary adjudication. Judgment upon the award shall be entered in the court in which such proceeding was commenced and all parties shall have full
rights of appeal. This provision will not be deemed to limit or constrain Lender’s right of offset, to obtain provisional or ancillary remedies, to interplead funds in the event of a dispute, to exercise any security interest or lien Lender may
hold in property or to comply with legal process involving Borrower’s accounts or other property. 
 Definitions. The following
capitalized words and terms shall have the following meanings when used in this Guaranty. Unless specifically stated to the contrary, all references to dollar amounts shall mean amounts in lawful money of the United States of America. Words and
terms used in the singular shall include the plural, and the plural shall include the singular, as the context may require. Words and terms not otherwise defined in this Guaranty shall have the meanings attributed to such terms in the Uniform
Commercial Code: 
 BORROWER. The word “Borrower” means IRIS International, Inc. and includes all co-signers and co-makers
signing the Note and all their successors and assigns. 
 GUARANTOR. The word “Guarantor” means everyone signing this Guaranty,
including without limitation IRIS Molecular Diagnostics, Inc., and in each case, any signer’s successors and assigns. 

GUARANTOR’S SHARE OF THE INDEBTEDNESS. The words “Guarantor’s Share of the Indebtedness” mean Guarantor’s indebtedness to
Lender as more particularly described in this Guaranty. 
 GUARANTY. The word “Guaranty” means this guaranty from Guarantor to
Lender. 
 INDEBTEDNESS. The word “Indebtedness” means Borrower’s indebtedness to Lender as more particularly described in
this Guaranty. 
 LENDER. The word “Lender” means California Bank & Trust, its successors and assigns. 

NOTE. The word “Note” means the Note executed by IRIS International, Inc. in the original principal amount of $6,500,000.00 dated
February 7, 2002, together with all renewals of, extensions of, modifications of, refinancings of, consolidations of, and substitutions for the Note or Credit Agreement or any other subsequent Notes evidencing further Indebtedness. 

RELATED DOCUMENTS. The words “Related Documents” mean all promissory notes, credit agreements, loan agreements, environmental
agreements, guaranties, security agreements, mortgages, deeds of trust, security deeds, collateral mortgages, and all other instruments, agreements and documents, whether now or hereafter existing, executed in connection with the Indebtedness.

 EACH UNDERSIGNED GUARANTOR ACKNOWLEDGES HAVING READ ALL THE PROVISIONS OF THIS GUARANTY AND AGREES TO ITS
TERMS. IN ADDITION, EACH GUARANTOR UNDERSTANDS THAT THIS GUARANTY IS EFFECTIVE UPON GUARANTOR’S EXECUTION AND DELIVERY OF THIS GUARANTY TO LENDER AND THAT THE GUARANTY WILL CONTINUE UNTIL TERMINATED IN THE MANNER SET FORTH IN THE SECTION TITLED
“DURATION OF GUARANTY”. NO FORMAL ACCEPTANCE BY LENDER IS NECESSARY TO MAKE THIS GUARANTY EFFECTIVE. THIS GUARANTY IS DATED AUGUST 31, 2010. 

GUARANTOR: 
  

			
	IRIS MOLECULAR DIAGNOSTICS, INC.
		
	By:	 	 /s/ Cesar M. Garcia

	Cesar M. Garcia, President of IRIS Molecular Diagnostics, Inc.

LASER PRO Lending, Ver. 5.52.20.003 Copr. Harland Financial Solutions, Inc. 1997, 2010. All Rights Reserved. - CA L:\CFI\LPL\E20.FC
TR-36507 PR-1 (M)

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