Document:

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                          QUINTILES TRANSNATIONAL CORP.

               $450,000,000 10% SENIOR SUBORDINATED NOTES DUE 2013

                          REGISTRATION RIGHTS AGREEMENT

                                                              New York, New York
                                                              September 25, 2003

Citigroup Global Markets Inc.
   As Representatives of the Initial Purchasers
   named in Schedule I hereto
c/o Citigroup Global Markets Inc.
388 Greenwich Street
New York, New York  10013

Ladies and Gentlemen:

                  Quintiles Transnational Corp., a corporation organized under
the laws of the State of North Carolina ("Quintiles"), proposes, among other
things, to issue and sell to the several initial purchasers named in Schedule I
hereto (the "Initial Purchasers"), for whom you are acting as representatives
(the "Representatives"), $450,000,000 aggregate principal amount of its 10%
Senior Subordinated Notes due 2013 (the "Notes") upon the terms set forth in a
purchase agreement dated September 12, 2003 (the "Purchase Agreement") relating
to the initial placement of the Notes (the "Initial Placement"). The Notes are
being issued in connection with the consummation of the merger of Pharma
Services Acquisition Corp., a North Carolina corporation ("Acquisition Corp"),
with and into Quintiles, as described in the Final Memorandum (as defined
herein). The Notes will be guaranteed (the "Guarantees") on an unsecured senior
subordinated basis by all of the subsidiaries of Quintiles that are organized in
the United States and, as required under the Indenture (as defined herein), any
future domestic subsidiaries and any subsidiary that guarantees Quintiles' or
any of its domestic subsidiaries' debt (collectively, the "Subsidiary
Guarantors"). References herein to the "Securities" refer to the Notes and the
Guarantees collectively. To induce the Initial Purchasers to enter into the
Purchase Agreement and to satisfy a condition of your obligations thereunder,
the Issuers (as defined herein) hereby agree with you for your benefit and the
benefit of the registered holders from time to time of Securities and Exchange
Securities (as defined herein) (including the Initial Purchasers) (each a
"Holder" and, together, the "Holders" for as long as such Person holds
Securities), as follows:

                  1.       Definitions. Capitalized terms used herein without
definition shall have their respective meanings set forth in the Purchase
Agreement. As used in this Agreement, the following defined terms shall have the
following respective meanings:

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                  "Act" shall mean the Securities Act of 1933, as amended.

                  "Affiliate" of, or Person "affiliated" with, any specified
Person shall mean any Person that directly, or indirectly through one or more
intermediaries, controls, is controlled by, or is under common control with,
such specified Person. For purposes of this definition, "control" of a Person
shall mean the possession, direct or indirect, of the power to direct or cause
the direction of the management and policies of such Person, whether through the
ownership of voting securities, by contract or otherwise; and the terms
"controlling" and "controlled by" and "under common control with" shall have
meanings correlative to the foregoing.

                  "Agreement" shall have the meaning set forth in the preamble
hereto.

                  "Banc One" means Banc One Capital Markets, Inc., an Initial
Purchaser named in Schedule I hereto.

                  "Broker-Dealer" shall mean any broker or dealer registered as
such under the Exchange Act.

                  "Business Day" shall mean any day other than a Saturday, a
Sunday or a legal holiday or a day on which banking institutions or trust
companies are authorized or obligated by law to close in New York City.

                  "Commission" shall mean the Securities and Exchange
Commission.

                  "Conduct Rules" shall have the meaning set forth in Section
4(t) hereof.

                  "Exchange Act" shall mean the Securities Exchange Act of 1934,
as amended.

                  "Exchange Offer Registration Period" shall mean the up to
90-day period following the consummation of the Registered Exchange Offer,
exclusive of any period during which any stop order shall be in effect
suspending the effectiveness of the Exchange Offer Registration Statement.

                  "Exchange Offer Registration Statement" shall mean a
registration statement of the Issuers on an appropriate form under the Act with
respect to the Registered Exchange Offer, all amendments and supplements to such
registration statement, including post-effective amendments thereto, in each
case including the Prospectus contained therein, all exhibits thereto and all
material incorporated by reference therein.

                  "Exchange Securities" shall mean debt securities of the
Issuers identical in all material respects to the Securities (except that the
additional interest provisions, the transfer

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restrictions and the restrictive legends shall be modified or eliminated, as
appropriate) and to be issued under the Indenture.

                  "Exchanging Dealer" shall mean any Holder (which may include
any Initial Purchaser) that is a Broker-Dealer and elects to exchange any
Securities that it acquired for its own account as a result of market-making
activities or other trading activities (but not directly from any Issuer or any
Affiliate of any Issuer) for Exchange Securities.

                  "Final Memorandum" shall have the meaning set forth in the
Purchase Agreement.

                  "Guarantees" shall have the meaning set forth in the preamble
hereto.

                  "Holder(s)" shall have the meaning set forth in the preamble
hereto.

                  "Indenture" shall mean the Indenture relating to the
Securities, to be dated as of the original issuance of the Securities, among the
Issuers and Wells Fargo Bank Minnesota, N.A., as trustee, as amended, amended
and restated or supplemented from time to time in accordance with the terms
thereof.

                  "Initial Placement" shall have the meaning set forth in the
preamble hereto.

                  "Initial Purchasers" shall have the meaning set forth in the
preamble hereto.

                  "Inspector" shall have the meaning set forth in Section
4(q)(ii).

                  "Issuers" shall mean Quintiles and the Subsidiary Guarantors.

                  "Losses" shall have the meaning set forth in Section 6(d)
hereof.

                  "Majority Holders" shall mean the Holders of a majority of the
aggregate principal amount of Securities and Exchange Securities, as the case
may be, registered under a Registration Statement.

                  "Managing Underwriters" shall mean the investment banker or
investment bankers and manager or managers that shall administer an underwritten
offering.

                  "Notes" shall have the meaning set forth in the preamble
hereto.

                  "Person" shall mean an individual, trustee, corporation,
partnership, limited liability company, joint stock company, trust,
unincorporated association, union, business association, firm or other legal
entity.

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                  "Prospectus" shall mean the prospectus included in any
Registration Statement (including, without limitation, a prospectus that
discloses information previously omitted from a prospectus filed as part of an
effective registration statement in reliance upon Rule 430A under the Act), as
amended or supplemented by any prospectus supplement, with respect to the terms
of the offering of any portion of the Securities or the Exchange Securities
covered by such Registration Statement, and all amendments and supplements
thereto and all material incorporated by reference therein.

                  "Purchase Agreement" shall have the meaning set forth in the
preamble hereto.

                  "Quintiles" shall have the meaning set forth in the preamble
hereto.

                  "Registered Exchange Offer" shall mean the proposed offer of
the Issuers to issue and deliver to the Holders of the Securities that are not
prohibited by any law or policy of the Commission from participating in such
offer a like aggregate principal amount of Exchange Securities in exchange for
the Securities.

                  "Registration Default" shall have the meaning set forth in
Section 3(c).

                  "Registration Default Period" shall have the meaning set forth
in Section 3(c).

                  "Registration Statement" shall mean any Exchange Offer
Registration Statement or Shelf Registration Statement that covers any of the
Securities or the Exchange Securities pursuant to the provisions of this
Agreement, any amendments and supplements to such registration statement,
including post-effective amendments (in each case including the Prospectus
contained therein), all exhibits thereto and all material incorporated by
reference therein.

                  "Representatives" shall have the meaning set forth in the
preamble hereto.

                  "Securities" shall mean the Notes and the Guarantees.

                  "Shelf Registration" shall mean a registration effected
pursuant to Section 3 hereof.

                  "Shelf Registration Period" shall have the meaning set forth
in Section 3(b)(ii) hereof.

                  "Shelf Registration Statement" shall mean a "shelf"
registration statement of the Issuers prepared and filed with the Commission
pursuant to the provisions of Section 3 hereof which covers some or all of the
Securities or Exchange Securities, as applicable, on an appropriate form under
Rule 415 under the Act, or any successor or similar rule that may be adopted by
the Commission, amendments and supplements to such registration statement,

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including post-effective amendments, in each case including the Prospectus
contained therein, all exhibits thereto and all material incorporated by
reference therein.

                  "Subsidiary Guarantors" shall have the meaning set forth in
the preamble hereto.

                  "Trustee" shall mean the trustee with respect to the
Securities under the Indenture.

                  "underwriter" shall mean any Person deemed an "underwriter,"
under the Act, of Securities or Exchange Securities in connection with an
offering thereof under a Shelf Registration Statement.

                  2.       Registered Exchange Offer. (a) To the extent not
prohibited by any applicable law or any applicable interpretation or any
applicable policy of the staff of the Commission, (i) the Issuers shall use
their reasonable best efforts to prepare and, not later than 180 days following
the Closing Date (or if such 180th day is not a Business Day, the next
succeeding Business Day), file with the Commission the Exchange Offer
Registration Statement with respect to the Registered Exchange Offer and (ii)
the Issuers shall use their respective reasonable best efforts to cause the
Exchange Offer Registration Statement to become effective under the Act not
later than 270 days following the Closing Date (or if such 270th day is not a
Business Day, the next succeeding Business Day).

                  (b)      Upon the effectiveness of the Exchange Offer
Registration Statement, the Issuers shall promptly commence the Registered
Exchange Offer, it being the objective of such Registered Exchange Offer to
enable each Holder electing to exchange Securities for Exchange Securities
(assuming that such Holder is not an Affiliate of any Issuer, acquires the
Exchange Securities in the ordinary course of such Holder's business, is not
engaged in and does not intend to engage in and has no arrangements or
understandings with any Person to participate in the distribution of the
Exchange Securities, is not a broker-dealer tendering Securities directly
acquired from any Issuer for its own account and is not prohibited by any law,
interpretation or policy of the Commission from participating in the Registered
Exchange Offer) to trade such Exchange Securities from and after their receipt
without any limitations or restrictions under the Act and under state securities
or blue sky laws.

                  (c)      In connection with the Registered Exchange Offer, the
Issuers shall:

                  (i)      mail to each Holder a copy of the Prospectus forming
         part of the Exchange Offer Registration Statement, together with an
         appropriate letter of transmittal and related documents;

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                  (ii)     keep the Registered Exchange Offer open for not less
         than 30 days after the date notice thereof is mailed to the Holders (or
         longer if required by applicable law);

                  (iii)    if the Issuers receive notice from an Exchanging
         Dealer that such Exchanging Dealer holds Securities acquired for the
         account of such Exchanging Dealer as a result of market making or other
         trading activities, use their respective reasonable best efforts to
         keep the Exchange Offer Registration Statement continuously effective
         under the Act, supplemented and amended as required under the Act to
         ensure that it is available for sales of Exchange Securities by
         Exchanging Dealers during the Exchange Offer Registration Period;

                  (iv)     utilize the services of a depositary for the
         Registered Exchange Offer with an address in the Borough of Manhattan
         in New York City, which may be the Trustee or an Affiliate of the
         Trustee;

                  (v)      permit Holders to withdraw tendered Securities at any
         time prior to the close of business, New York City time, on the last
         Business Day on which the Registered Exchange Offer is open by sending
         to the entity specified in the Prospectus, a facsimile or letter
         setting forth the name of such Holder, the principal amount of the
         Securities delivered for exchange and a statement that such Holder is
         withdrawing such Holder's election to have such Securities exchanged;

                  (vi)     prior to effectiveness of the Exchange Offer
         Registration Statement, if requested by the Commission, provide a
         supplemental letter to the Commission (A) stating that the Issuers are
         conducting the Registered Exchange Offer in reliance on the position of
         the Commission in Exxon Capital Holdings Corporation (pub. avail. May
         13, 1988) and Morgan Stanley and Co. Incorporated (pub. avail. June 5,
         1991); and (B) including a representation that the Issuers have not
         entered into any arrangement or understanding with any Person to
         distribute the Exchange Securities to be received in the Registered
         Exchange Offer and that, to the best of the Issuers' information and
         belief, each Holder participating in the Registered Exchange Offer is
         acquiring the Exchange Securities in the ordinary course of business
         and has no arrangement or understanding with any Person to participate
         in the distribution of the Exchange Securities; and

                  (vii)    comply in all material respects with all applicable
         laws relating to the Registered Exchange Offer.

                  (d)      Promptly after the close of the Registered Exchange
         Offer, the Issuers shall:

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                  (i)      accept for exchange all Securities validly tendered
         and not validly withdrawn pursuant to the Registered Exchange Offer in
         accordance with the terms of the Exchange Offer Registration Statement
         and letter of transmittal, which shall be an exhibit thereto;

                  (ii)     deliver to the Trustee for cancellation in accordance
         with Section 4(r) hereof all Securities so accepted for exchange; and

                  (iii)    cause the Trustee promptly to authenticate and
         deliver to each Holder of Securities a principal amount of Exchange
         Securities equal to the principal amount of the Securities of such
         Holder so accepted for exchange; provided that in the case of any
         Securities held in global form by a depository, authentication and
         delivery to such depository of one or more replacement Securities in
         global form in an equivalent amount thereto for the account of such
         Holders in accordance with the Indenture shall satisfy such
         authentication and delivery requirement.

                  (e)      Each Holder, by tendering Securities for exchange for
Exchange Securities, acknowledges and agrees that any Broker-Dealer and any such
Holder using the Registered Exchange Offer to participate in a distribution of
the Exchange Securities (x) could not under Commission policy as in effect on
the date of this Agreement rely on the position of the Commission in Morgan
Stanley and Co. Incorporated (pub. avail. June 5, 1991) and Exxon Capital
Holdings Corporation (pub. avail. May 13, 1988), as interpreted in Shearman &
Sterling (pub. avail. July 2, 1993) and similar no-action letters; and (y) must
comply with the registration and prospectus delivery requirements of the Act in
connection with any secondary resale transaction and must be covered by an
effective registration statement containing the selling security holder
information required by Items 507 and 508 of Regulation S-K, as applicable,
under the Act if the resales are of Exchange Securities obtained by such Holder
in exchange for Securities acquired by such Holder directly from any Issuer or
one of its Affiliates. Accordingly, each Holder participating in the Registered
Exchange Offer shall be required to represent to the Issuers in writing (which
may be contained in the letter of transmittal contemplated by the Registered
Exchange Offer) that, at the time of the consummation of the Registered Exchange
Offer:

                  (i)      any Exchange Securities received by such Holder will
         be acquired in the ordinary course of business;

                  (ii)     such Holder will have no arrangement or understanding
         with any Person to participate in the distribution of the Securities or
         the Exchange Securities within the meaning of the Act; and

                  (iii)    such Holder is not an Affiliate of any Issuer.

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                  (f)      If any Initial Purchaser determines that it is not
eligible to participate in the Registered Exchange Offer with respect to the
exchange of Securities constituting any portion of an unsold allotment, at the
written request of such Initial Purchaser, the Issuers shall issue and deliver
to such Initial Purchaser or the Person purchasing Exchange Securities
registered under a Shelf Registration Statement as contemplated by Section 3
hereof from such Initial Purchaser, in exchange for such Securities, or Exchange
Securities, as the case may be, a like principal amount of the Securities (the
"Private Exchange Securities") of Quintiles that are identical in all material
respects to the Exchange Securities except for the placement of a restrictive
legal legend on such Private Exchange Securities. The Issuers shall use their
respective reasonable best efforts to cause the CUSIP Service Bureau to issue
the same CUSIP number for such Private Exchange Securities as for Exchange
Securities issued pursuant to the Registered Exchange Offer.

                  3.       Shelf Registration. (a) If (i) Banc One notifies
Quintiles in writing that it reasonably believes it or any of its affiliates is
required by applicable law or the Commission's policy to deliver a Prospectus in
connection with market-making resales of the Securities; (ii) due to any change
in law, applicable interpretations thereof or changes in policy by the
Commission's staff, the Issuers determine upon advice of their outside counsel
that they are not permitted to effect the Registered Exchange Offer as
contemplated by Section 2 hereof; (iii) for any other reason the Exchange Offer
Registration Statement is not declared effective within 270 days, or the
Registered Exchange Offer is not consummated within 300 days, after the Issue
Date; or (iv) prior to the 20th day following consummation of the Registered
Exchange Offer the Company receives written notice that (A) any Initial
Purchaser so requests with respect to Securities (or Private Exchange
Securities) that are not eligible to be exchanged for Exchange Securities in the
Registered Exchange Offer and that are held by it following consummation of the
Registered Exchange Offer; (B) any Holder (other than an Initial Purchaser or
Exchanging Dealer) is not eligible to participate in the Registered Exchange
Offer; or (C) in the case of any Initial Purchaser that participates in the
Registered Exchange Offer or acquires Private Exchange Securities pursuant to
Section 2(f) hereof, such Initial Purchaser does not receive freely tradeable
Exchange Securities in exchange for Securities constituting any portion of an
unsold allotment (it being understood that (x) the requirement that an Initial
Purchaser deliver a Prospectus containing the information required by Items 507
and 508 of Regulation S-K, as applicable, under the Act in connection with sales
of Exchange Securities acquired in exchange for such Securities shall result in
such Exchange Securities being not "freely tradeable"; and (y) the requirement
that an Exchanging Dealer deliver a Prospectus in connection with sales of
Exchange Securities acquired in the Registered Exchange Offer in exchange for
Securities acquired as a result of market-making activities or other trading
activities shall not result in such Exchange Securities being not "freely
tradeable"), the Issuers shall effect a Shelf Registration Statement in
accordance with Section 3(b) hereof. For all purposes of this Agreement, the
obligation to have a Shelf Registration Statement declared effective under
Section 3(a)(iv) shall be deemed to arise as set forth in Section 3(b)(i). The
obligation to file a Shelf Registration Statement

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under Section 3(a)(iv) shall be deemed to arise on the later of the 180th day
after the Issue Date or the day the Company receives notice relating to a
Section 3(a)(iv) Shelf Registration Statement.

                  (b)      (i) The Issuers shall as promptly as reasonably
practicable (but in no event more than 30 days after so required or requested
pursuant to Section 3(a)(i), (ii) or (iii) and no later than the later of the
60th day after so required pursuant to Section 3(a)(iv) or the 180th day after
the Issue Date), file with the Commission, and thereafter shall use their
respective reasonable best efforts to cause to be declared effective under the
Act (within 180 days after so required or requested pursuant to Section 3(a)(i),
(ii) or (iii) or within 60 days of the filing date of a Shelf Registration
Statement required or requested pursuant to Section 3(a)(iv)), a Shelf
Registration Statement relating to the offer and sale of the Securities or the
Exchange Securities, as applicable, by the Holders thereof from time to time in
accordance with the methods of distribution elected by a majority of such
Holders and set forth in such Shelf Registration Statement; provided, however,
that nothing in this Section 3(b) shall require the filing of a Shelf
Registration Statement prior to the deadline for filing the Exchange Offer
Registration Statement set forth in Section 2(a); provided, further, that a
Shelf Registration Statement requested pursuant to Section 3(a)(i) shall be
declared effective no later than the first business day following the
consummation of the Registered Exchange Offer; provided, further, that no
Holder (other than an Initial Purchaser) shall be entitled to have the
Securities held by it covered by such Shelf Registration Statement unless such
Holder agrees in writing to be bound by all of the provisions of this Agreement
applicable to such Holder; and provided, further, that with respect to Exchange
Securities or Private Exchange Securities received by an Initial Purchaser in
exchange for Securities constituting any portion of an unsold allotment, the
Issuers may, if permitted by current interpretations by the Commission's staff,
file a post-effective amendment to the Exchange Offer Registration Statement
containing the information required by Items 507 and 508 of Regulation S-K, as
applicable, in satisfaction of their obligations under this subsection with
respect thereto, and any such Exchange Offer Registration Statement, as so
amended, shall be referred to herein as, and governed by the provisions herein
applicable to, a Shelf Registration Statement.

                  (ii)     The Issuers shall use their respective reasonable
best efforts to keep the Shelf Registration Statement continuously effective,
supplemented and amended as required by the Act, in order to permit the
Prospectus forming part thereof to be usable by Holders for a period of two
years from the original issuance date of the Securities or such shorter period
that will terminate when all the Securities or Exchange Securities, as
applicable, covered by the Shelf Registration Statement have been sold pursuant
to the Shelf Registration Statement or cease to be outstanding (in any such
case, such period being called the "Shelf Registration Period"); provided,
however, upon notice from Banc One pursuant to Section 3(a)(i) hereof, on or
prior to the date specified for such filings in this Agreement such Shelf
Registration Period shall be extended for the purpose of covering resales of the
Securities, Private Exchange Securities or Exchange Securities by Banc One until
such time as Banc One shall
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                                      -10-

have notified Quintiles that neither it nor any of its Affiliates is required by
applicable law or the Commission's policy to deliver a Prospectus in connection
with any resale of Securities, Exchange Securities or Private Exchange
Securities. The Company shall be deemed not to have used its reasonable best
efforts to keep a Shelf Registration Statement effective during the Shelf
Registration Period if it voluntarily takes any action that would result in
Holders of Securities covered thereby not being able to use such Shelf
Registration Statement to offer and sell such Securities covered by such Shelf
Registration Statement at any time during the Shelf Registration Period, unless
such action is (x) required by the Commission, applicable law or otherwise
undertaken by the Company in good faith and for valid business reasons (not
including avoidance of the Company's obligations hereunder), including the
acquisition or divestiture of assets, and (y) permitted pursuant to Section
4(k)(ii) hereof.

                  (c)      In the event that:

                  (i)      within 180 days after the Issue Date, neither the
         Exchange Offer Registration Statement nor, if required to be filed
         pursuant to Section 3(a)(i), (ii) or (iii) above, any Shelf
         Registration Statement has been filed with the Commission;

                  (ii)     within 30 days after a Shelf Registration Statement
         is required to be filed pursuant to Section 3(a)(i), (ii) or (iii), so
         long as such 30th day is a day after the 180th day following the Issue
         Date, the Shelf Registration Statement has not been filed with
         Commission;

                  (iii)    within 270 days after the Issue Date, the Exchange
         Offer Registration Statement has not been declared effective as
         required by Section 2(a);

                  (iv)     within 300 days after the Issue Date, neither the
         Exchange Offer has been consummated nor, if required to be filed
         pursuant to Section 3(a)(i), (ii) or (iii) above, the Shelf
         Registration Statement has been declared effective;

                  (v)      within 60 days of the day on which the obligation to
         file a Shelf Registration Statement arises pursuant solely to Section
         3(a)(iv) above, the Issuers fail to file such Shelf Registration
         Statement with the Commission;

                  (vi)     within 60 days of the day on which the obligation to
         have a Shelf Registration Statement declared effective arises pursuant
         solely to Section 3(a)(iv) above, such Shelf Registration Statement has
         not been declared effective; or

                  (vii)    after either the Exchange Offer Registration
         Statement or the Shelf Registration Statement has been declared
         effective, such Registration Statement thereafter ceases to be
         effective or fails to be usable in connection with resales of
         Securities or Exchange Securities in accordance with and during the
         periods specified in this Agreement, other than as permitted pursuant
         to Section 3(b)(ii) and Section 4(k)(ii).

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                                      -11-

(each such event a "Registration Default" and each period during which a
Registration Default has occurred and is continuing, a "Registration Default
Period"), then, as liquidated damages for such Registration Default, additional
interest will accrue on the aggregate principal amount solely those Securities
and Exchange Securities subject to such Registration Default (in addition to the
stated interest on the Securities and Exchange Securities) from and including
the date on which any such Registration Default shall occur to, but excluding
the date that is the earlier of (1) the date on which all Registration Defaults
applicable to the subject Securities and Exchange Securities have been cured or
(2) the date on which all the Securities and Exchange Securities otherwise
become freely transferable by Holders other than Affiliates of the Issuers
without further registration under the Act. Additional interest will accrue at
an initial rate of 0.25% per annum, which rate shall increase by 0.25% per annum
for each subsequent 90-day period during which such Registration Default
continues up to a maximum of 1.00% per annum. If, after the cure of all
Registration Defaults then in effect, there is a subsequent Registration
Default, the rate of additional interest for such subsequent Registration
Default shall initially be 0.25% regardless of the rate in effect with respect
to any prior Registration Default at the time of cure of such Registration
Default. Notwithstanding the foregoing, the amount of additional interest
payable shall not increase because more than one Registration Default has
occurred and is pending.

                  4.       Additional Registration Procedures. In connection
with any Shelf Registration Statement and, to the extent applicable, any
Exchange Offer Registration Statement, the following provisions shall apply:

                  (a)      the Issuers shall:

                           (i)      furnish to each of you or your counsel, not
                  less than three Business Days prior to the filing thereof with
                  the Commission, a copy of the Exchange Offer Registration
                  Statement or the Shelf Registration Statement, as the case may
                  be, and each amendment thereto and each amendment or
                  supplement, if any, to the Prospectus included therein (and
                  upon written request, all documents incorporated by reference
                  therein after the initial filing) and shall use their
                  reasonable best efforts to reflect in each such document, when
                  so filed with the Commission, such comments as you reasonably
                  propose within a reasonable time prior to such filing;

                           (ii)     in the case of an Exchange Offer
                  Registration Statement, to the extent permitted by the Act,
                  include the information in substantially the form set forth in
                  Annex A hereto on the facing page of the Exchange Offer
                  Registration Statement, in substantially the form set forth in
                  Annex B hereto in the forepart of the Exchange Offer
                  Registration Statement in a section setting forth details of
                  the Exchange Offer, in substantially the form set forth in
                  Annex C hereto in the underwriting or plan of distribution
                  section of the Prospectus

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                                      -12-

                  contained in the Exchange Offer Registration Statement, and in
                  substantially the form set forth in Annex D hereto in the
                  letter of transmittal delivered pursuant to the Registered
                  Exchange Offer; and

                           (iii)    in the case of a Shelf Registration
                  Statement, subject to clause (n) below, include the names of
                  the Holders that propose to sell Securities or Exchange
                  Securities pursuant to the Shelf Registration Statement as
                  selling security holders and the applicable information
                  required by Items 507 and 508 of Regulation S-K as provided by
                  the Holders.

                  (b)      The Company shall ensure that:

                           (i)      any Registration Statement and any amendment
                  thereto and any Prospectus forming part thereof and any
                  amendment or supplement thereto complies in all material
                  respects with the Act; and

                           (ii)     any Registration Statement and any amendment
                  thereto does not, when it becomes effective, contain an untrue
                  statement of a material fact or omit to state a material fact
                  required to be stated therein or necessary to make the
                  statements therein not misleading.

                  (c)      The Issuers shall advise you, the Holders of
         Securities or Exchange Securities covered by any Shelf Registration
         Statement and any Exchanging Dealer under any Exchange Offer
         Registration Statement that has provided in writing to any Issuer a
         telephone or facsimile number and address for notices, and, if
         requested by you or any such Holder or Exchanging Dealer, shall confirm
         such advice in writing (which notice pursuant to clauses (ii)-(v)
         hereof shall be accompanied by an instruction to suspend the use of the
         Prospectus until the Issuers shall have remedied the basis for such
         suspension):

                           (i)      when a Registration Statement or any
                  amendment thereto has been filed with the Commission and when
                  the Registration Statement or any post-effective amendment
                  thereto has become effective;

                           (ii)     of any request by the Commission for any
                  amendment or supplement to the Registration Statement or the
                  Prospectus or for additional information;

                           (iii)    of the issuance by the Commission of any
                  stop order suspending the effectiveness of the Registration
                  Statement or the initiation of any proceedings for that
                  purpose;

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                                      -13-

                           (iv)     of the receipt by any Issuer of any
                  notification with respect to the suspension of the
                  qualification of the Securities included therein for sale in
                  any jurisdiction or the initiation of any proceeding for such
                  purpose; and

                           (v)      of the happening of any event that requires
                  any change in the Registration Statement or the Prospectus so
                  that, as of such date, the statements therein are not
                  misleading and do not omit to state a material fact required
                  to be stated therein or necessary to make the statements
                  therein (in the case of the Prospectus, in the light of the
                  circumstances under which they were made) not misleading;
                  provided that such notice need not identify the reasons for
                  such event that requires such change in the Registration
                  Statement.

                  (d)      The Issuers shall use their respective reasonable
         best efforts to obtain the withdrawal of any order suspending the
         effectiveness of any Registration Statement or the qualification of the
         Securities therein for sale in any jurisdiction at the earliest
         possible time.

                  (e)      The Issuers shall furnish to each Holder of
         Securities or Exchange Securities covered by any Shelf Registration
         Statement, without charge, at least one copy of such Shelf Registration
         Statement and any post-effective amendment thereto, including, upon
         written request, all material incorporated therein by reference and
         exhibits thereto (including exhibits incorporated by reference
         therein).

                  (f)      The Issuers shall, during the Shelf Registration
         Period, deliver to each Holder of Securities or Exchange Securities
         covered by any Shelf Registration Statement, without charge, as many
         copies of the Prospectus (including each preliminary Prospectus)
         included in such Shelf Registration Statement and any amendment or
         supplement thereto as such Holder may reasonably request. The Issuers
         consent to the use (in all cases in accordance with applicable law and
         subject to compliance with the terms of this Agreement) of the
         Prospectus or any amendment or supplement thereto by each of the
         selling Holders of Securities in connection with the offering and sale
         of the Securities covered by the Prospectus, or any amendment or
         supplement thereto, included in the Shelf Registration Statement.

                  (g)      The Issuers shall furnish to each Exchanging Dealer
         which so requests, without charge, at least one copy of the Exchange
         Offer Registration Statement and any post-effective amendment thereto,
         including, upon written request, all material incorporated by reference
         therein, and all exhibits thereto (including exhibits incorporated by
         reference therein).

                  (h)      The Issuers shall promptly deliver to each Initial
         Purchaser, each Exchanging Dealer and each other Person required to
         deliver a Prospectus during the Exchange Offer Registration Period,
         without charge, as many copies of the Prospectus

<PAGE>

                                      -14-

         included in such Exchange Offer Registration Statement and any
         amendment or supplement thereto as any such Person may reasonably
         request. The Issuers consent to the use (in all cases in accordance
         with applicable law and subject to compliance with the terms of this
         Agreement) of the Prospectus or any amendment or supplement thereto by
         any Initial Purchaser, any Exchanging Dealer and any such other Person
         that may be required to deliver a Prospectus following the Registered
         Exchange Offer in connection with the offering and sale of the Exchange
         Securities covered by the Prospectus, or any amendment or supplement
         thereto, included in the Exchange Offer Registration Statement.

                  (i)      Prior to the Registered Exchange Offer or any other
         offering of Securities or Exchange Securities pursuant to any
         Registration Statement, the Issuers shall arrange, if necessary, for
         the qualification of the Securities or the Exchange Securities for sale
         under the laws of such jurisdictions as any Holder shall reasonably
         request and will maintain such qualification in effect so long as
         required; provided that in no event shall any Issuer be obligated (i)
         to qualify to do business in any jurisdiction where it is not then so
         qualified or (ii) to take any action that would subject it to taxation
         or service of process in suits, other than those arising out of the
         Initial Placement, the Registered Exchange Offer or any offering
         pursuant to a Shelf Registration Statement, in any such jurisdiction
         where it is not then so subject.

                  (j)      The Issuers shall cooperate with the Holders to
         facilitate the timely preparation and delivery of certificates
         representing Exchange Securities or Securities to be issued or sold
         pursuant to any Registration Statement free of any restrictive legends
         and in such denominations and registered in such names as Holders may
         request.

                  (k)

                           (i)      Upon the occurrence of any event
                  contemplated by subsections (c)(ii) through (v) above, the
                  Issuers shall promptly prepare a post-effective amendment to
                  the applicable Registration Statement or an amendment or
                  supplement to the related Prospectus or file any other
                  required document so that, as thereafter delivered to Initial
                  Purchasers, the Prospectus will not include an untrue
                  statement of a material fact or omit to state any material
                  fact necessary to make the statements therein, in the light of
                  the circumstances under which they were made, not misleading.
                  In such circumstances, the period of effectiveness of the
                  Exchange Offer Registration Statement provided for in Section
                  2 hereof and the Shelf Registration Statement provided for in
                  Section 3(b) hereof shall each be extended by the number of
                  days from and including the date of the giving of a notice of
                  suspension pursuant to Section 4(c) hereof to and including
                  the date when the Initial Purchasers, the Holders and any
                  known Exchanging Dealer shall have

<PAGE>

                                      -15-

                  received such amended or supplemented Prospectus pursuant to
                  this Section 4; or

                           (ii)     Upon the occurrence or existence of any
                  pending corporate development or any other material event
                  that, in the reasonable judgment of Quintiles, makes it
                  appropriate to suspend the availability of a Shelf
                  Registration Statement and the related Prospectus, Quintiles
                  shall give notice (without notice of the nature or details of
                  such events) to the Holders that the availability of the Shelf
                  Registration is suspended and, upon actual receipt of any such
                  notice, each Holder agrees not to sell any registrable
                  Securities pursuant to the Shelf Registration until such
                  Holder's receipt of copies of the supplemented or amended
                  Prospectus provided for in Section 4(h) hereof, or until it is
                  advised in writing by Quintiles that the Prospectus may be
                  used, and has received copies of any additional or
                  supplemental filings that are incorporated or deemed
                  incorporated by reference in such Prospectus. The period
                  during which the availability of the Shelf Registration and
                  any Prospectus is suspended shall not exceed 45 days in any
                  three-month period or 90 days in any twelve-month period.

         Notwithstanding this Section 4(k), in no event shall the Issuers be
         required to maintain the effectiveness of any Exchange Offer
         Registration Statement or Shelf Registration Statement beyond the
         second anniversary of the original Issue Date of the Securities, except
         as set forth in Section 3(b)(ii). As soon as practicable following
         receipt of notice from the Issuers in accordance with Sections 4(c) or
         (k) hereof, as the case maybe, each Holder and Exchanging Dealer agrees
         to suspend use of the Prospectus until such Holder and Exchanging
         Dealer receives copies of the amended or supplemented Prospectus or
         until it receives written notice from the Issuers that the use of the
         applicable Prospectus may be resumed.

                  (l)      Not later than the effective date of any Registration
         Statement, the Issuers shall provide a CUSIP number for the Securities
         or the Exchange Securities, as the case may be, registered under such
         Registration Statement and provide the Trustee with printed
         certificates for such Securities or Exchange Securities, in a form
         eligible for deposit with The Depository Trust Company.

                  (m)      The Issuers shall comply with all applicable rules
         and regulations of the Commission and make generally available to their
         security holders as soon as practicable after the effective date of the
         applicable Registration Statement an earnings statement satisfying the
         provisions of Section 11(a) of the Act.

                  (n)      The Issuers shall cause the Indenture to be qualified
         under the Trust Indenture Act of 1939, as amended, in a timely manner.

<PAGE>

                                      -16-

                  (o)      The Issuers may require each Holder of Securities to
         be sold pursuant to any Shelf Registration Statement to furnish to the
         Issuers such information regarding the Holder and the distribution of
         such Securities as the Issuers may from time to time reasonably require
         for inclusion in such Registration Statement. The Issuers may exclude
         from such Shelf Registration Statement the Securities or Exchange
         Securities of any Holder that unreasonably fails to furnish such
         information within a reasonable time after receiving such request and
         the failure to include such Securities or Exchange Securities of any
         such Holder shall not be deemed to be a default hereunder. Each Holder
         agrees to promptly furnish additional information required to be
         disclosed in order to make the information previously furnished to the
         Issuers by such Holder, regarding such Holder, not materially
         misleading.

                  (p)      In the case of any Shelf Registration Statement, the
         Issuers shall enter into such and take all other appropriate actions
         (including, if requested by Holders representing 10% of the aggregate
         principal amount of Securities covered by such Shelf Registration
         Statement, an underwriting agreement in customary form) in order to
         expedite or facilitate the registration or the disposition of the
         Securities or Exchange Securities, and in connection therewith, if an
         underwriting agreement is entered into, cause the same to contain
         indemnification provisions and procedures no less favorable than those
         set forth in Section 6 (or such other provisions and procedures
         acceptable to the Majority Holders and the Managing Underwriters, if
         any, with respect to all parties to be indemnified pursuant to Section
         6).

                  (q)      In the case of any Shelf Registration Statement, the
         Issuers shall:

                           (i)      upon written request and reasonable advance
                  notice, make reasonably available for inspection by the
                  Holders of Securities or Exchange Securities to be registered
                  thereunder, any underwriter participating in any disposition
                  pursuant to such Shelf Registration Statement, and any
                  attorney retained by the Holders or any such underwriter all
                  relevant financial and other records, pertinent corporate
                  documents and properties of each Issuer during normal business
                  hours at the offices where such information is typically kept;

                           (ii)     upon written request and reasonable advance
                  notice, cause the officers, directors and employees of each
                  Issuer to supply all relevant information reasonably requested
                  by the Holders or any such underwriter or attorney in
                  connection with any such Shelf Registration Statement (each an
                  "Inspector") as is customary for similar due diligence
                  examinations during normal business hours at the offices where
                  such information is typically kept; provided, however, that
                  each Inspector shall agree in writing that any confidential
                  information referred to in Section 4(q)(i) above or this
                  Section 4(q)(ii) shall be kept confidential by such Inspector,
                  unless such disclosure is

<PAGE>

                                      -17-

                  made in connection with a court proceeding or required by law,
                  or such information becomes available to the public generally
                  or through a third party (other than an Affiliate of such
                  Inspector) without an accompanying obligation of
                  confidentiality; provided, further, that prior written notice
                  shall be provided as soon as practicable to the applicable
                  Issuer of the potential disclosure of any information in
                  connection with a court proceeding or required by law to
                  permit such Issuer to obtain a protective order or take such
                  other action to prevent disclosure of such information;

                           (iii)    make such representations and warranties to
                  the Holders of Securities or Exchange Securities registered
                  thereunder and the underwriters, if any, in form, substance
                  and scope as are customarily made by issuers to underwriters
                  in primary underwritten offerings and covering matters
                  including, but not limited to, those set forth in the Purchase
                  Agreement as may be reasonably requested;

                           (iv)     obtain opinions of counsel to the Issuers
                  (which may be the Issuers' internal counsel) and updates
                  thereof (which counsel and opinions (in form, scope and
                  substance) shall be reasonably satisfactory to the Managing
                  Underwriters, if any) addressed to each selling Holder (if
                  then customary in underwritten offerings) and the
                  underwriters, if any, covering such matters as are customarily
                  covered in opinions requested in underwritten offerings and
                  such other matters as may be reasonably requested by such
                  Holders and underwriters;

                           (v)      obtain "cold comfort" letters and updates
                  thereof from the independent certified public accountants of
                  Quintiles (and, if necessary, any other independent certified
                  public accountants of any Issuer or any subsidiary of any
                  Issuer or of any business acquired by any Issuer for which
                  financial statements and financial data are, or are required
                  to be, included in the Shelf Registration Statement),
                  addressed to the underwriters, if any, in customary form and
                  covering matters of the type customarily covered in "cold
                  comfort" letters in connection with primary underwritten
                  offerings; and

                           (vi)     deliver such documents and certificates as
                  may be reasonably requested by the Majority Holders and the
                  Managing Underwriters, if any, including those to evidence
                  compliance with Section 4(l) and with any customary conditions
                  contained in the underwriting agreement or other customary
                  agreement entered into by the Issuers.

         The actions set forth in clauses (iii), (iv), (v) and (vi) of this
         Section 4(q) shall be performed at each closing under any underwriting
         or similar agreement as and to the extent required thereunder.

<PAGE>

                                      -18-

                  (r)      If a Registered Exchange Offer is to be consummated,
         upon delivery of the Securities by Holders to Quintiles (or to such
         other Person as directed by Quintiles) in exchange for the Exchange
         Securities, Quintiles shall mark, or caused to be marked, on the
         Securities so exchanged that such Securities are being canceled in
         exchange for the Exchange Securities. In no event shall the Securities
         be marked as paid or otherwise satisfied.

                  (s)      The Issuers will use their respective reasonable best
         efforts if the Securities have been rated prior to the initial sale of
         such Securities pursuant to the Purchase Agreement, to confirm such
         ratings will apply to the Securities or the Exchange Securities, as the
         case may be, covered by an Exchange Offer Registration Statement.

                  (t)      In the event that any Broker-Dealer shall underwrite
         any Securities or Exchange Securities or participate as a member of an
         underwriting syndicate or selling group or "assist in the distribution"
         (within the meaning of the Conduct Rules of the National Association of
         Securities Dealers, Inc. (the "Conduct Rules")) thereof, whether as a
         Holder or as an underwriter, a placement or sales agent or a broker or
         dealer in respect thereof, or otherwise, the Issuers shall assist such
         Broker-Dealer in complying with the requirements of such Conduct Rules,
         including, without limitation, by:

                           (i)      if such Conduct Rules shall so require,
                  engaging a "qualified independent underwriter" (as defined in
                  such Rules) to participate in the preparation of the
                  Registration Statement, to exercise usual standards of due
                  diligence with respect thereto and, if any portion of the
                  offering contemplated by such Registration Statement is an
                  underwritten offering or is made through a placement or sales
                  agent, to recommend the yield of such Securities or Exchange
                  Securities;

                           (ii)     indemnifying any such qualified independent
                  underwriter to the extent of the indemnification of
                  underwriters provided in Section 6 hereof; and

                           (iii)    providing such information to such
                  Broker-Dealer as may be required in order for such
                  Broker-Dealer to comply with the requirements of such Conduct
                  Rules.

                  (u)      The Issuers shall cooperate with the Holders
         participating in the disposition of the Securities and one counsel
         acting on behalf of all such Holders in connection with the filings, if
         any, required to be made with the NASD.

                  (v)      The Issuers shall use their respective reasonable
         best efforts to take all other steps necessary to effect the
         registration of the Securities or the Exchange Securities, as the case
         may be, covered by a Registration Statement.

<PAGE>

                                      -19-

                  5.       Registration Expenses. The Issuers shall bear all
expenses incurred in connection with the performance of their obligations under
Sections 2, 3 and 4 hereof, and, in the event of any Shelf Registration
Statement, will reimburse the Holders for the reasonable fees and disbursements
of one firm or counsel designated by the Majority Holders to act as counsel for
the Holders in connection therewith and, in the case of any Exchange Offer
Registration Statement, will reimburse the Initial Purchasers for the reasonable
fees and disbursements of such one firm or counsel acting in connection
therewith. Each Holder shall pay all commissions and transfer taxes, if any,
relating to the sale or disposition of such Holder's Securities.

                  6.       Indemnification and Contribution. (a) The Issuers
jointly and severally agree to indemnify and hold harmless each Holder of
Securities or Exchange Securities, as the case may be, covered by any
Registration Statement (including each Initial Purchaser and, with respect to
any Prospectus delivery as contemplated in Section 4(h) hereof, each Exchanging
Dealer), the directors, officers, employees and agents of each such Holder and
each Person who controls any such Holder within the meaning of either Section 15
of the Act or Section 20 of the Exchange Act against any and all losses, claims,
damages or liabilities, joint or several, to which they or any of them may
become subject under the Act, the Exchange Act or other Federal, state or
foreign statutory law or regulation, at common law or otherwise, insofar as such
losses, claims, damages or liabilities (or actions in respect thereof) arise out
of or are based upon any untrue statement or alleged untrue statement of a
material fact contained in any such Registration Statement as originally filed
or in any amendment thereof, or in any preliminary prospectus or the Prospectus,
or in any amendment thereof or supplement thereto, or arise out of or are based
upon the omission or alleged omission to state therein a material fact required
to be stated therein or necessary to make the statements therein not misleading,
and jointly and severally agree to reimburse each such indemnified party, as
incurred, for any legal or other expenses reasonably incurred by it in
connection with investigating or defending any such loss, claim, damage,
liability or action; provided, however, that the Issuers will not be liable in
any case to the extent that any such loss, claim, damage or liability arises out
of or is based upon any such untrue statement or alleged untrue statement or
omission or alleged omission made therein in reliance upon and in conformity
with written information furnished to any Issuer by or on behalf of any such
Holder relating to such Holder specifically for inclusion therein.

                  Each Issuer also jointly and severally agrees to indemnify or
contribute as provided in Section 6(d) (below) to Losses of each underwriter of
Securities or Exchange Securities, as the case may be, registered under a Shelf
Registration Statement, its directors, officers, employees or agents and each
Person who controls such underwriter on substantially the same basis as that of
the indemnification of the Initial Purchasers and the selling Holders provided
in this Section 6(a) and shall, if requested by any Holder, enter into an
underwriting agreement reflecting such agreement, as provided in Section 4(p)
hereof.

<PAGE>

                                      -20-

                  (b)      Each Holder of Securities covered by a Registration
Statement (including each Initial Purchaser and, with respect to any Prospectus
delivery as contemplated in Section 4(h) hereof, each Exchanging Dealer)
severally agrees to indemnify and hold harmless each of the Issuers, each of
their respective directors, officers or agents and each Person who controls any
Issuer within the meaning of either the Act or the Exchange Act, to the same
extent as the foregoing indemnity from the Issuers to each such Holder, but only
in reliance upon and conformity with written information relating to such Holder
furnished to the Issuers by or on behalf of such Holder specifically for
inclusion in the documents referred to in the foregoing indemnity. This
indemnity agreement will be in addition to any liability which any such Holder
may otherwise have.

                  (c)      Promptly after receipt by an indemnified party under
this Section 6 of notice of the commencement of any action, such indemnified
party will, if a claim in respect thereof is to be made against the indemnifying
party under this Section 6, notify the indemnifying party in writing of the
commencement thereof; but the failure so to notify the indemnifying party (i)
will not relieve it from liability under paragraph (a) or (b) above unless and
to the extent it did not otherwise learn of such action and such failure results
in the forfeiture by the indemnifying party of substantial rights and defenses;
and (ii) will not, in any event, relieve the indemnifying party from any
obligations to any indemnified party other than the indemnification obligation
provided in paragraph (a) or (b) above. The indemnifying party shall be entitled
to appoint counsel of the indemnifying party's choice at the indemnifying
party's expense to represent the indemnified party in any action for which
indemnification is sought (in which case the indemnifying party shall not
thereafter be responsible for the fees and expenses of any separate counsel
retained by the indemnified party or parties except as set forth below);
provided, however, that such counsel shall be reasonably satisfactory to the
indemnified party. Notwithstanding the indemnifying party's election to appoint
counsel to represent the indemnified party in an action, the indemnified party
shall have the right to employ one firm of separate counsel (in addition to one
local counsel firm), and the indemnifying party shall bear the reasonable fees,
costs and expenses of such separate counsel if (i) the use of counsel chosen by
the indemnifying party to represent the indemnified party would present such
counsel with an actual conflict of interest; (ii) the actual or potential
defendants in, or targets of, any such action include both the indemnified party
and the indemnifying party and the indemnified party shall have reasonably
concluded, based upon the advice of counsel, that there may be legal defenses
available to it and/or other indemnified parties which are different from or
additional to those available to the indemnifying party; (iii) the indemnifying
party shall not have employed counsel reasonably satisfactory to the indemnified
party to represent the indemnified party within a reasonable time after notice
of the institution of such action; or (iv) the indemnifying party shall
authorize the indemnified party to employ separate counsel at the expense of the
indemnifying party. It is understood, however, that the indemnifying party
shall, in connection with any one such action or separate but substantially
similar or related actions in the same jurisdiction arising out of the same
general circumstances, be liable for the fees and

<PAGE>

                                      -21-

expenses of only one firm of attorneys (in addition to one local counsel) at any
time for all such indemnified parties. An indemnifying party will not, without
the prior written consent of the indemnified parties, settle or compromise or
consent to the entry of any judgment with respect to any pending or threatened
claim, action, suit or proceeding in respect of which indemnification or
contribution may be sought hereunder (whether or not the indemnified parties are
actual or potential parties to such claim or action) unless such settlement,
compromise or consent (i) includes an unconditional release of each indemnified
party from all liability arising out of such claim, action, suit or proceeding
and (ii) does not include a statement as to, or an admission of, fault or
culpability or failure to act by or on behalf of any indemnified party.

                  (d)      In the event that the indemnity provided in paragraph
(a) or (b) of this Section is unavailable to or insufficient to hold harmless an
indemnified party for any reason, then each applicable indemnifying party shall
have a joint and several obligation to contribute to the aggregate losses,
claims, damages and liabilities (including legal or other expenses reasonably
incurred in connection with investigating or defending same) (collectively
"Losses") to which such indemnified party may be subject in such proportion as
is appropriate to reflect the relative benefits received by such indemnifying
party, on the one hand, and such indemnified party, on the other hand, from the
Initial Placement and the Registration Statement which resulted in such Losses;
provided, however, that in no case shall any Initial Purchaser or any subsequent
Holder of any Security or Exchange Security be responsible, in the aggregate,
for any amount in excess of the purchase discount or commission applicable to
such Security or, in the case of an Exchange Security, applicable to the
Security that was exchangeable into such Exchange Security, as set forth on the
cover page of the Final Memorandum, nor shall any underwriter be responsible for
any amount in excess of the underwriting discount or commission applicable to
the Securities purchased by such underwriter under the Registration Statement
which resulted in such Losses. If the allocation provided by the immediately
preceding sentence is unavailable for any reason, the indemnifying party and the
indemnified party shall contribute in such proportion as is appropriate to
reflect not only such relative benefits but also the relative fault of such
indemnifying party, on the one hand, and such indemnified party, on the other
hand, in connection with the statements or omissions which resulted in such
Losses as well as any other relevant equitable considerations. The relative
benefits received by the Issuers shall be deemed to be equal to the total net
proceeds from the Initial Placement (before deducting expenses) as set forth on
the cover page of the Final Memorandum. The relative benefits received by the
Initial Purchasers shall be deemed to be equal to the total purchase discounts
and commissions as set forth on the cover page of the Final Memorandum and
benefits received by any other Holders shall be deemed to be equal to the value
of receiving Securities or Exchange Securities, as applicable, registered under
the Act. Benefits received by any underwriter shall be deemed to be equal to the
total underwriting discounts and commissions, as set forth on the cover page of
the Prospectus forming a part of the Registration Statement which resulted in
such Losses. Relative fault shall be determined by reference to, among

<PAGE>

                                      -22-

other things, whether any alleged untrue statement of a material fact or
omission to state a material fact relates to information provided by the
indemnifying party, on the one hand, or by the indemnified party, on the other
hand, the intent of the parties and their relative knowledge, access to
information and opportunity to correct or prevent such untrue statement or
omission. The parties agree that it would not be just and equitable if
contribution were determined by pro rata allocation (even if the Holders were
treated as one entity for such purpose) or any other method of allocation which
does not take account of the equitable considerations referred to above.
Notwithstanding the provisions of this paragraph (d), no Person guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the Act)
shall be entitled to contribution from any Person who was not guilty of such
fraudulent misrepresentation. For purposes of this Section 6, each Person who
controls a Holder within the meaning of either the Act or the Exchange Act and
each director, officer, employee and agent of such Holder shall have the same
rights to contribution as such Holder, and each Person who controls any Issuer
within the meaning of either the Act or the Exchange Act, each officer of any
Issuer who shall have signed the Registration Statement and each director of any
Issuer shall have the same rights to contribution as the Issuers, subject in
each case to the applicable terms and conditions of this paragraph (d).

                  (e)      The provisions of this Section 6 will remain in full
force and effect, regardless of any investigation made by or on behalf of any
Holder or the Issuers or any of the officers, directors or controlling Persons
referred to in this Section 6, and will survive the sale by a Holder of
Securities covered by a Registration Statement.

                  7.       Underwritten Registrations. (a) If any of the
Securities or Exchange Securities, as the case may be, covered by any Shelf
Registration Statement are to be sold in an underwritten offering, the Managing
Underwriter(s) shall be selected by the Majority Holders and shall be reasonably
satisfactory to Quintiles.

                  (b)      No Person may participate in any underwritten
offering pursuant to any Shelf Registration Statement, unless such Person (i)
agrees to sell such Person's Securities or Exchange Securities, as the case may
be, on the basis reasonably provided in any underwriting arrangements approved
by the Persons entitled hereunder to approve such arrangements; and (ii)
completes and executes all questionnaires, powers of attorney, indemnities,
underwriting agreements and other documents reasonably required under the terms
of such underwriting arrangements.

                  8.       No Inconsistent Agreements. No Issuer has, as of the
date hereof, entered into, nor shall it, on or after the date hereof, enter
into, any agreement with respect to its securities that is inconsistent with the
rights granted to the Holders herein or otherwise conflicts with the provisions
hereof.

                  9.       Amendments and Waivers. The provisions of this
Agreement, including the provisions of this sentence, may not be amended,
qualified, modified or

<PAGE>

                                      -23-

supplemented, and waivers or consents to departures from the provisions hereof
may not be given, otherwise than with the prior written consent of (i) the
Issuers and (ii) the Majority Holders; provided that, with respect to any matter
that directly or indirectly affects any rights of any Initial Purchaser
hereunder, the Issuers shall obtain the written consent of each of the Initial
Purchasers against which such amendment, qualification, supplement, waiver or
consent is to be effective. Notwithstanding the foregoing (except the foregoing
proviso), a waiver or consent to departure from the provisions hereof with
respect to a matter that relates exclusively to the rights of Holders whose
Securities or Exchange Securities, as the case may be, are being sold pursuant
to a Registration Statement and that does not directly or indirectly affect the
rights of other Holders may be given by the Majority Holders, determined on the
basis of Securities or Exchange Securities, as the case may be, being sold
rather than registered under such Registration Statement.

                  10.      Notices. All notices and other communications
provided for or permitted hereunder shall be made in writing by hand delivery,
first-class mail, telex, telecopier or air courier guaranteeing overnight
delivery:

                  (a)      if to a Holder, at the most current address given by
         such Holder to the Issuers in accordance with the provisions of this
         Section 10, which address initially is, with respect to each Holder,
         the address of such Holder maintained by the Registrar under the
         Indenture, with a copy in like manner to Citigroup Global Markets Inc.;

                  (b)      if to you, initially at the respective addresses set
         forth in the Purchase Agreement; and

                  (c)      if to the Issuers, initially at their address set
         forth in the Purchase Agreement.

                  All such notices and communications shall be deemed to have
been duly given at the time delivered personally, if personally delivered; two
business days after being deposited in the mail, postage prepaid, if mailed;
when answered back, if telexed; when receipt is acknowledged, if telecopied; and
on the next business day, if timely delivered to a nationally recognized air
courier guaranteeing overnight delivery.

                  The Initial Purchasers or the Issuers by notice to the other
parties may designate additional or different addresses for subsequent notices
or communications.

                  11.      Successors. This Agreement shall inure to the benefit
of and be binding upon the successors and assigns of each of the parties hereto,
including, without the need for an express assignment or any consent, by the
Issuers and subsequent Holders of Securities and Exchange Securities. The
Issuers hereby agree to extend the benefits of this Agreement to any Holder of
Securities or Exchange Securities, and any such Holder may specifically enforce
the provisions of this Agreement as if an original party hereto; provided,

<PAGE>

                                      -24-

however, that nothing herein shall be deemed to permit any assignment, transfer
or other disposition of Securities or Exchange Securities in violation of the
terms of the Indenture or Purchase Agreement.

                  12.      Counterparts. This Agreement may be in signed
counterparts, each of which shall be an original and all of which together shall
constitute one and the same agreement.

                  13.      Headings. The headings used herein are for
convenience only and shall not affect the construction hereof.

                  14.      Applicable Law. This Agreement shall be governed by
and construed in accordance with the laws of the State of New York applicable to
contracts made and to be performed in the State of New York.

                  15.      Entire Agreement. This Agreement is intended by the
parties as a final expression of their agreement and intended to be a complete
and exclusive statement of the agreement and understanding of the parties hereto
in respect of the subject matter contained herein. There are no restrictions,
promises, warranties or undertakings, other than those set forth or referred to
herein, with respect to the registration rights granted with respect to the
Securities and Exchange Securities. This Agreement supersedes all prior
agreements and understandings between the parties with respect to such subject
matter.

                  16.      Severability. In the event that any one or more of
the provisions contained herein, or the application thereof in any
circumstances, is held invalid, illegal or unenforceable in any respect for any
reason, the validity, legality and enforceability of any such provision in every
other respect and of the remaining provisions hereof shall not be in any way
impaired or affected thereby, it being intended that all of the rights and
privileges of the parties shall be enforceable to the fullest extent permitted
by law.

                  17.      Securities Held by the Issuers, etc. Whenever the
consent or approval of Holders of a specified percentage of principal amount of
Securities or Exchange Securities is required hereunder, Securities or Exchange
Securities, as applicable, held by any Issuer or its Affiliates (other than
subsequent Holders of Securities or Exchange Securities if such subsequent
Holders are deemed to be Affiliates solely by reason of their holdings of such
Securities or Exchange Securities) shall not be counted in determining whether
such consent or approval was given by the Holders of such required percentage.

                  18.      Submission to Jurisdiction. By the execution and
delivery of this Agreement, each Issuer submits to the non-exclusive
jurisdiction of any federal or state court in the State of New York in any suit
or proceeding arising out of or relating to this Agreement or brought under
federal or state securities laws. By receiving the rights and benefits under
this Agreement, each Holder also submits to the non-exclusive jurisdiction of
any federal or

<PAGE>

                                      -25-

state court in the State of New York in any suit or proceeding arising out of or
relating to this Agreement or brought under federal or state securities laws.

                            [Signature Page Follows]

<PAGE>

                                      -26-

                  If the foregoing is in accordance with your understanding of
our agreement, please sign and return to us the enclosed duplicate hereof,
whereupon this letter and your acceptance shall represent a binding agreement
among each Issuer and the several Initial Purchasers.

                                                   Very truly yours,

                                                   QUINTILES TRANSNATIONAL CORP.

                                                   By: _________________________
                                                       John S. Russell
                                                       Executive Vice President

<PAGE>

                                      -27-

                                    BENEFIT HOLDING, INC.
                                    BENEFIT TRANSNATIONAL HOLDING CORP.
                                    BIOGLAN PHARMACEUTICALS COMPANY
                                    INNOVEX (NORTH AMERICA) INC.
                                    INNOVEX AMERICA HOLDING COMPANY
                                    INNOVEX MERGER CORP.
                                    MEDCOM, INC.
                                    PHARMABIO DEVELOPMENT, INC.
                                    PHARMA INFORMATICS, INC.
                                    PMSI DATABASE SERVICES, INC.
                                    PMSI FINANCE LIMITED
                                    PMSI HOLDINGS LIMITED
                                    PMSI SCOTT-LEVIN, INC.
                                    Q.E.D COMMUNICATIONS, INC.
                                    QFINANCE, INC.
                                    QUINTILES ASIA, INC.
                                    QUINTILES CLINICAL SUPPLIES AMERICAS, INC.
                                    QUINTILES FEDERATED SERVICES, INC.
                                    QUINTILES, INC.
                                    QUINTILES INFORMATICS, INC.
                                    QUINTILES LABORATORIES LIMITED
                                    QUINTILES LATIN AMERICA, INC.
                                    QUINTILES PACIFIC, INC.
                                    QUINTILES PHASE ONE SERVICES, INC.
                                    QUINTILES SCOTT-LEVIN, INC.
                                    QUINTILES TECHNOLOGIES, INC.
                                    SOURCE INFORMATICS EUROPEAN FINANCE, INC.
                                    SOURCE INFORMATICS EUROPEAN HOLDINGS, INC.
                                    THE LEWIN GROUP, INC.

                                    By:_________________________________________
                                       John S. Russell
                                       President

<PAGE>

                                      -28-

                                    INNOVEX, L.P.

                                    INNOVEX AMERICAN HOLDING COMPANY,
                                    as General Partner

                                    By:  _______________________________
                                         John S. Russell
                                         President

                                    MSM GROUP LIMITED PARTNERSHIP,
                                    as Limited Partner

                                       QUINTILES PACIFIC, INC.,
                                       as General Partner

                                    By: _______________________
                                        John S. Russell
                                        President

                                    INNOVEX (NORTH AMERICA) INC.,
                                    as Limited Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

<PAGE>

                                      -29-

                                    INNOVEX NEVADA LIMITED PARTNERSHIP

                                    QUINTILES PACIFIC, INC.,
                                    as General Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

                                    INNOVEX (NORTH AMERICA) INC.,
                                    as Limited Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

<PAGE>

                                      -30-

                                    INNOVEX SUPPORT SERVICES LIMITED
                                    PARTNERSHIP

                                    INNOVEX AMERICA HOLDING COMPANY,
                                    as General Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

                                    INNOVEX NEVADA LIMITED PARTNERSHIP,
                                    as Limited Partner

                                       QUINTILES PACIFIC, INC.
                                       as General Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

                                    INNOVEX (NORTH AMERICA) INC.,
                                    as Limited Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

<PAGE>

                                      -31-

                                    MSM GROUP LIMITED PARTNERSHIP

                                    QUINTILES PACIFIC, INC.,
                                    as General Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

                                    INNOVEX (NORTH AMERICA) INC.,
                                    as Limited Partner

                                    By: _______________________________
                                        John S. Russell
                                        President

<PAGE>

                                      -32-

                                    QUINTILES TRANSFER, L.L.C.

                                    QUINTILES PACIFIC, INC.,
                                    as sole Member

                                    By: _______________________________
                                        John S. Russell
                                        President

<PAGE>

                                      -33-

                                    SOURCE INFORMATICS EUROPEAN
                                    HOLDINGS, LLC

                                    SOURCE INFORMATICS EUROPEAN
                                    HOLDINGS, INC.,
                                    as sole Member

                                    By: _______________________________
                                        John S. Russell
                                        President

<PAGE>

                                      -34-

                                    QUINTILES AUSTRIAN HOLDINGS, LLC

                                    Quintiles Transnational Corp.
                                    as sole Member

                                    By: _______________________________
                                        John S. Russell
                                        Executive Vice President

<PAGE>

                                      -35-

The foregoing Agreement is
hereby confirmed and accepted
as of the date first above written.

Citigroup Global Markets Inc.

By: ________________________________
    Name:
    Title:

For itself and the other several Initial
Purchasers named in Schedule I to
the foregoing Agreement.

<PAGE>

                                                                      SCHEDULE I

Initial Purchasers:

Citigroup Global Markets Inc.
ABN AMRO Incorporated
Banc One Capital Markets, Inc.

                                    Sch. I-1

<PAGE>

                                                                         ANNEX A

                  Each Broker-Dealer that receives Exchange Securities for its
own account pursuant to the Exchange Offer must acknowledge that it will deliver
a prospectus in connection with any resale of such Exchange Securities. The
letter of transmittal states that by so acknowledging and by delivering a
prospectus, a Broker-Dealer will not be deemed to admit that it is an
"underwriter" within the meaning of the Act. This Prospectus, as it may be
amended or supplemented from time to time, may be used by a Broker-Dealer in
connection with resales of Exchange Securities received in exchange for
Securities where such Securities were acquired by such Broker-Dealer as a result
of market-making activities or other trading activities. The Issuers have agreed
that, starting on the expiration date and ending on the close of business 90
days after the expiration date, they will make this Prospectus available to any
Broker-Dealer for use in connection with any such resale. See "Plan of
Distribution."

                                       A-1

<PAGE>

                                                                         ANNEX B

                  Each Broker-Dealer that receives Exchange Securities for its
own account in exchange for Securities, where such Securities were acquired by
such Broker-Dealer as a result of market-making activities or other trading
activities, must acknowledge that it will deliver a prospectus in connection
with any resale of such Exchange Securities. See "Plan of Distribution."

                                       B-1

<PAGE>

                                                                         ANNEX C

                              Plan of Distribution

                  Each Broker-Dealer that receives Exchange Securities for its
own account pursuant to the Exchange Offer must acknowledge that it will deliver
a prospectus in connection with any resale of such Exchange Securities. This
Prospectus, as it may be amended or supplemented from time to time, may be used
by a Broker-Dealer in connection with resales of Exchange Securities received in
exchange for Securities where such Securities were acquired as a result of
market-making activities or other trading activities. The Issuers have agreed
that, starting on the expiration date and ending on the close of business 180
days after the expiration date, they will make this Prospectus, as amended or
supplemented, available to any Broker-Dealer for use in connection with any such
resale. In addition, until ___________, 200__, all dealers effecting
transactions in the Exchange Securities may be required to deliver a prospectus.

                  The Issuers will not receive any proceeds from any sale of
Exchange Securities by Broker-Dealers. Exchange Securities received by
Broker-Dealers for their own account pursuant to the Exchange Offer may be sold
from time to time in one or more transactions in the over-the-counter market, in
negotiated transactions, through the writing of options on the Exchange
Securities or a combination of such methods of resale, at market prices
prevailing at the time of resale, at prices related to such prevailing market
prices or negotiated prices. Any such resale may be made directly to purchasers
or to or through brokers or dealers who may receive compensation in the form of
commissions or concessions from any such Broker-Dealer and/or the purchasers of
any such Exchange Securities. Any Broker-Dealer that resells Exchange Securities
that were received by it for its own account pursuant to the Exchange Offer and
any broker or dealer that participates in a distribution of such Exchange
Securities may be deemed to be an "underwriter" within the meaning of the Act
and any profit of any such resale of Exchange Securities and any commissions or
concessions received by any such Persons may be deemed to be underwriting
compensation under the Act. The letter of transmittal states that by
acknowledging that it will deliver and by delivering a prospectus, a
Broker-Dealer will not be deemed to admit that it is an "underwriter" within the
meaning of the Act.

                  For a period of 90 days after the Expiration Date, the Issuers
will promptly send additional copies of this Prospectus and any amendment or
supplement to this Prospectus to any Broker-Dealer that requests such documents
in the letter of transmittal. The Issuers have agreed to pay all expenses
incident to the Exchange Offer (including the expenses of one counsel for the
holder of the Securities) other than commissions or concessions of any brokers
or dealers and will indemnify the holders of the Securities (including any
Broker-Dealers) against certain liabilities, including liabilities under the
Act.

                                       C-1

<PAGE>

                                                                         ANNEX D

[ ]      CHECK HERE IF YOU ARE A BROKER-DEALER AND WISH TO RECEIVE 10
         ADDITIONAL COPIES OF THE PROSPECTUS AND 10 COPIES OF ANY AMENDMENTS OR
         SUPPLEMENTS THERETO.

         Name:             _________________________________________
         Address:          _________________________________________
                           _________________________________________

If the undersigned is not a Broker-Dealer, the undersigned represents that it
acquired the Exchange Securities in the ordinary course of its business, it is
not engaged in, and does not intend to engage in, a distribution of Exchange
Securities and it has no arrangements or understandings with any Person to
participate in a distribution of the Exchange Securities. If the undersigned is
a Broker-Dealer that will receive Exchange Securities for its own account in
exchange for Securities, it represents that the Securities to be exchanged for
Exchange Securities were acquired by it as a result of market-making activities
or other trading activities and acknowledges that it will deliver a prospectus
in connection with any resale of such Exchange Securities; however, by so
acknowledging and by delivering a prospectus, the undersigned will not be deemed
to admit that it is an "underwriter" within the meaning of the Act.

                                       D-1<PAGE>

                                                                  EXECUTION COPY

                                CREDIT AGREEMENT

                            Dated September 25, 2003

                                      among

                         QUINTILES TRANSNATIONAL CORP.,
                                as the Borrower,

                          PHARMA SERVICES HOLDING, INC.
                                       and
                   PHARMA SERVICES INTERMEDIATE HOLDING CORP.,
                              as Parent Guarantors,

                         THE LENDERS REFERRED TO HEREIN

                              --------------------

                         CITIGROUP GLOBAL MARKETS INC.,
                    as Sole Lead Arranger and Sole Bookrunner

                                       and

                          CITICORP NORTH AMERICA, INC.,
                            as Administrative Agent,

                              --------------------

                               ABN AMRO BANK N. V.
                                       and
                         BANC ONE MEZZANINE CORPORATION
                            as Co-Syndication Agents
                                       and

                        RESIDENTIAL FUNDING CORPORATION,
                         (DBA GMAC--RFC HEALTH CAPITAL)
                             as Documentation Agent

                              --------------------

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                                                              Page
                                                                                                                              ----
                                   ARTICLE I

                                  DEFINITIONS
<S>            <C>                                                                                                            <C>
SECTION 1.01.  Defined Terms................................................................................................    1
SECTION 1.02.  Classification of Loans and Borrowings.......................................................................   39
SECTION 1.03.  Terms Generally..............................................................................................   39
SECTION 1.04.  Exchange Rates...............................................................................................   40

                                   ARTICLE II

                                   THE CREDITS

SECTION 2.01.  Credit Commitments...........................................................................................   40
SECTION 2.02.  Procedure for Borrowing......................................................................................   41
SECTION 2.03.  Conversion and Continuation Options for Loans................................................................   43
SECTION 2.04.  Provisions Relating to Foreign Currency Loans................................................................   44
SECTION 2.05.  Swingline Loans..............................................................................................   45
SECTION 2.06.  Optional and Mandatory Prepayments of Loans; Repayments of Term B Loans......................................   47
SECTION 2.07.  Letters of Credit............................................................................................   51
SECTION 2.08.  Repayment of Loans; Evidence of Debt.........................................................................   55
SECTION 2.09.  Interest Rates and Payment Dates.............................................................................   56
SECTION 2.10.  Computation of Interest......................................................................................   57
SECTION 2.11.  Fees.........................................................................................................   57
SECTION 2.12.  Termination, Reduction or Adjustment of Commitments..........................................................   58
SECTION 2.13.  Inability to Determine Interest Rate; Unavailability of Deposits; Inadequacy of Interest Rate................   59
SECTION 2.14.  Pro Rata Treatment and Payments..............................................................................   59
SECTION 2.15.  Illegality...................................................................................................   61
SECTION 2.16.  Requirements.................................................................................................   61
SECTION 2.17.  Taxes........................................................................................................   62
SECTION 2.18.  Indemnity....................................................................................................   64
SECTION 2.19.  Change of Lending Office.....................................................................................   64
SECTION 2.20.  Sharing of Setoffs...........................................................................................   65
SECTION 2.21.  Assignment of Commitments Under Certain Circumstances........................................................   65

                                   ARTICLE III

                         REPRESENTATIONS AND WARRANTIES

SECTION 3.01.  Organization, etc............................................................................................   66
</TABLE>

                                      -i-

<PAGE>

<TABLE>
<CAPTION>
                                                                                                                              Page
                                                                                                                              ----
<S>            <C>                                                                                                            <C>
SECTION 3.02.  Due Authorization, Non-Contravention, etc....................................................................   66
SECTION 3.03.  Government Approval, Regulation, etc.........................................................................   67
SECTION 3.04.  Validity, etc................................................................................................   67
SECTION 3.05.  Activities of Parent Guarantors and Acquisition Corp.........................................................   67
SECTION 3.06.  Representations and Warranties in the Merger Agreement.......................................................   67
SECTION 3.07.  Financial Information........................................................................................   68
SECTION 3.08.  [Reserved]...................................................................................................   68
SECTION 3.09.  No Material Adverse Change...................................................................................   68
SECTION 3.10.  Litigation...................................................................................................   68
SECTION 3.11.  Compliance with Laws and Agreements..........................................................................   68
SECTION 3.12.  Subsidiaries.................................................................................................   68
SECTION 3.13.  Ownership of Properties......................................................................................   69
SECTION 3.14.  Taxes........................................................................................................   70
SECTION 3.15.  Pension and Welfare Plans....................................................................................   70
SECTION 3.16.  Environmental Warranties.....................................................................................   70
SECTION 3.17.  Regulations U and X..........................................................................................   72
SECTION 3.18.  Disclosure; Accuracy of Information; Pro Forma Balance Sheets and Projected Financial Statements.............   72
SECTION 3.19.  Insurance....................................................................................................   73
SECTION 3.20.  Labor Matters................................................................................................   73
SECTION 3.21.  Solvency.....................................................................................................   73
SECTION 3.22.  Securities...................................................................................................   73
SECTION 3.23.  Indebtedness Outstanding.....................................................................................   74
SECTION 3.24.  Security Documents...........................................................................................   74
SECTION 3.25.  Anti-Terrorism Laws..........................................................................................   75

                                   ARTICLE IV

                                   CONDITIONS

SECTION 4.01.  Effective Date...............................................................................................   76
SECTION 4.02.  Conditions to Each Credit Event..............................................................................   83

                                    ARTICLE V

                              AFFIRMATIVE COVENANTS

SECTION 5.01.  Financial Information, Reports, Notices, etc.................................................................   84
SECTION 5.02.  Compliance with Laws, etc....................................................................................   87
SECTION 5.03.  Maintenance of Properties....................................................................................   87
SECTION 5.04.  Insurance....................................................................................................   88
SECTION 5.05.  Books and Records; Visitation Rights.........................................................................   88
SECTION 5.06.  Environmental Covenant.......................................................................................   89
SECTION 5.07.  Information Regarding Collateral.............................................................................   90
SECTION 5.08.  Existence; Conduct of Business...............................................................................   90
</TABLE>

                                      -ii-

<PAGE>

<TABLE>
<CAPTION>
                                                                                                                              Page
                                                                                                                              ----
<S>            <C>                                                                                                            <C>
SECTION 5.09.  Performance of Obligations...................................................................................   90
SECTION 5.10.  Casualty and Condemnation....................................................................................   90
SECTION 5.11.  Pledge of Additional Collateral..............................................................................   91
SECTION 5.12.  Further Assurances...........................................................................................   91
SECTION 5.13.  Use of Proceeds..............................................................................................   92
SECTION 5.14.  Payment of Taxes.............................................................................................   92
SECTION 5.15.  Equal Security for Loans and Notes...........................................................................   92
SECTION 5.16.  Guarantees...................................................................................................   93
SECTION 5.17.  Subordination of Loans.......................................................................................   93
SECTION 5.18.  Unrestricted Subsidiaries....................................................................................   93
SECTION 5.19.  Non-Pledgeable Permitted PharmaBio Investments...............................................................   93
SECTION 5.20.  Additional Mortgages.........................................................................................   94
SECTION 5.21.  Foreign Pledges..............................................................................................   94

                                   ARTICLE VI

                               NEGATIVE COVENANTS

SECTION 6.01.  Indebtedness; Certain Equity Securities......................................................................   95
SECTION 6.02.  Liens........................................................................................................   99
SECTION 6.03.  Fundamental Changes..........................................................................................  101
SECTION 6.04.  Investments, Loans, Advances, Guarantees and Acquisitions....................................................  102
SECTION 6.05.  Asset Sales..................................................................................................  104
SECTION 6.06.  Sale and Leaseback Transactions..............................................................................  105
SECTION 6.07.  Restricted Payments..........................................................................................  106
SECTION 6.08.  Transactions with Affiliates.................................................................................  107
SECTION 6.09.  Restrictive Agreements.......................................................................................  108
SECTION 6.10.  Amendments or Waivers of Certain Documents; Prepayments of Indebtedness......................................  109
SECTION 6.11.  No Other "Designated Senior Indebtedness"....................................................................  109
SECTION 6.12.  Limitation on Activities of Parent Guarantors................................................................  109
SECTION 6.13.  Interest Expense Coverage Ratio..............................................................................  110
SECTION 6.14.  Total Leverage Ratio.........................................................................................  110
SECTION 6.15.  Senior Leverage Ratio........................................................................................  111
SECTION 6.16.  Capital Expenditures.........................................................................................  112
SECTION 6.17.  Maintenance of Corporate Separateness........................................................................  112
SECTION 6.18.  Anti-Terrorism Law...........................................................................................  113
SECTION 6.19.  Embargoed Person.............................................................................................  113
SECTION 6.20.  Anti-Money Laundering........................................................................................  113

                                   ARTICLE VII

                                EVENTS OF DEFAULT

SECTION 7.01.  Listing of Events of Default.................................................................................  114
</TABLE>

                                     -iii-

<PAGE>

<TABLE>
<CAPTION>
                                                                                                                              Page
                                                                                                                              ----
<S>            <C>                                                                                                            <C>
SECTION 7.02.  Action if Bankruptcy.........................................................................................  117
SECTION 7.03.  Action if Other Event of Default.............................................................................  117
SECTION 7.04.  Action if Event of Termination...............................................................................  117

                                  ARTICLE VIII

                                   THE AGENTS

SECTION 8.01.  The Agents...................................................................................................  117

                                   ARTICLE IX

                                    GUARANTEE

SECTION 9.01.  Guarantee of the Parent Guarantors...........................................................................  119
SECTION 9.02.  Amendments, etc. with Respect to the Applicable Obligations..................................................  120
SECTION 9.03.  Guarantee Absolute and Unconditional.........................................................................  120
SECTION 9.04.  Reinstatement................................................................................................  121
SECTION 9.05.  Payments.....................................................................................................  121
SECTION 9.06.  Independent Obligations......................................................................................  121

                                    ARTICLE X

                                  MISCELLANEOUS

SECTION 10.01. Notices......................................................................................................  122
SECTION 10.02. Survival of Agreement........................................................................................  123
SECTION 10.03. Binding Effect...............................................................................................  123
SECTION 10.04. Successors and Assigns.......................................................................................  123
SECTION 10.05. Expenses; Indemnity..........................................................................................  127
SECTION 10.06. Right of Setoff..............................................................................................  129
SECTION 10.07. Applicable Law...............................................................................................  129
SECTION 10.08. Waivers; Amendment...........................................................................................  129
SECTION 10.09. Interest Rate Limitation.....................................................................................  131
SECTION 10.10. Entire Agreement.............................................................................................  131
SECTION 10.11. WAIVER OF JURY TRIAL.........................................................................................  131
SECTION 10.12. Severability.................................................................................................  131
SECTION 10.13. Counterparts.................................................................................................  132
SECTION 10.14. Headings.....................................................................................................  132
SECTION 10.15. Jurisdiction; Consent to Service of Process..................................................................  132
SECTION 10.16. Confidentiality..............................................................................................  132
SECTION 10.17. Citigroup Direct Website Communications......................................................................  134
SECTION 10.18. Collateral Agent as Joint Creditor...........................................................................  135
SECTION 10.19. Currency of Payment..........................................................................................  135
SECTION 10.20. Relationship of Banc One Mezzanine Corporation...............................................................  136
</TABLE>

                                      -iv-

<PAGE>

EXHIBIT A       Form of Administrative Questionnaire
EXHIBIT B       Form of Borrowing Request
EXHIBIT C       Form of Assignment and Acceptance
EXHIBIT D       Form of Collateral Sharing Agreement
EXHIBIT E       Form of Compliance Certificate
EXHIBIT F-1     Form of Term B Note
EXHIBIT F-2     Form of Revolving Note
EXHIBIT G       Form of Closing Certificate
EXHIBIT H       Form of Subsidiary Guarantee Agreement
EXHIBIT I       Form of Pledge Agreement
EXHIBIT J       Form of Security Agreement
EXHIBIT K-1     Form of Opinion of Morgan, Lewis & Bockius LLP
EXHIBIT K-2     Form of Opinion of Smith, Anderson, Blount, Mitchell & Jernigan,
                  L.L.P.
EXHIBIT L       Form of U.S. Local Counsel Opinion
EXHIBIT M       Form of Solvency Certificate
EXHIBIT N       Form of Mortgage
EXHIBIT O       Form of Officers' Certificate
EXHIBIT P       Form of Landlord Subordination

SCHEDULE 2.01           Lenders and Commitments
SCHEDULE 3.02           Non-Contravention
SCHEDULE 3.03           Government Approvals
SCHEDULE 3.09           Material Adverse Effect
SCHEDULE 3.10           Litigation
SCHEDULE 3.13(b)        Leased, Subleased and Owned Real Property
SCHEDULE 3.16           Environmental Warranties
SCHEDULE 3.19           Insurance
SCHEDULE 3.24(d)        Mortgage Filing Offices
SCHEDULE 4.01(c)        Local Counsel
SCHEDULE 4.01(w)        Non-U.S. Subsidiaries
SCHEDULE 4.01(y)(A)     Mortgaged Properties
SCHEDULE 4.01(y)(C)     Title Insurance Amounts
SCHEDULE 6.01(a)(iii)   Existing Indebtedness
SCHEDULE 6.01(a)(xx)    Employment Agreements
SCHEDULE 6.02           Existing Liens
SCHEDULE 6.04           Existing Investments
SCHEDULE 6.08           Transactions with Affiliates
SCHEDULE 6.09           Existing Restrictions

                                      -v-

<PAGE>

                  CREDIT AGREEMENT (this "Agreement") dated September 25, 2003,
among QUINTILES TRANSNATIONAL CORP., a North Carolina corporation (the
"Borrower"); PHARMA SERVICES HOLDING, INC., a Delaware corporation (the
"Parent"); PHARMA SERVICES INTERMEDIATE HOLDING CORP., a Delaware corporation
(the "Intermediate Parent"); the financial institutions listed on Schedule 2.01,
as such Schedule may from time to time be supplemented and amended (the
"Lenders"); CITICORP NORTH AMERICA, INC., as administrative agent (in such
capacity, the "Administrative Agent") for the Lenders; RESIDENTIAL FUNDING
CORPORATION (DBA GMAC -- RFC HEALTH CAPITAL) ("RFC"), as documentation agent (in
such capacity, the "Documentation Agent"); and CITIGROUP GLOBAL MARKETS INC.
("CGMI"), as sole lead arranger and sole bookrunner (the "Lead Arranger") and
ABN AMRO BANK N.V. ("ABN"), as co-syndication agent and BANC ONE MEZZANINE
CORPORATION ("Banc One"), as co-syndication agent (and together with ABN, the
"Syndication Agents").

                  The parties hereto agree as follows:

                                    ARTICLE I

                                   DEFINITIONS

                  SECTION 1.01. Defined Terms. As used in this Agreement, the
following terms shall have the meanings specified below:

                  "ABR Borrowing" means a Borrowing comprised of ABR Loans.

                  "ABR Loan" means any Loan bearing interest at the Alternate
Base Rate in accordance with the provisions of Article II.

                  "Acquisition Consideration" shall mean the purchase
consideration for any Permitted Acquisition and all other payments by the
Borrower or any of its Subsidiaries in exchange for, or as part of, or in
connection with any Permitted Acquisition, whether paid in cash or by exchange
of Equity Interests or of assets or otherwise and whether payable at or prior to
the consummation of such Permitted Acquisition or deferred for payment at any
future time, whether or not any such future payment is subject to the occurrence
of any contingency, and includes any and all payments representing the purchase
price and any assumptions of Indebtedness, "earn-outs" and other agreements to
make any payment the amount of which is, or the terms of payment of which are,
in any respect subject to or contingent upon the revenues, income, cash flow or
profits (or the like) of any person or business (such "earn-outs" and other
payments, "Contingent Payment Agreements"); provided that (i) ordinary course
indemnification obligations shall be excluded from Acquisition Consideration,
(ii) amounts paid to officers or employees of the Borrower or any of its
Subsidiaries (after giving effect to such Permitted Acquisition) and accounted
for as operating expenses under GAAP relating to compensation shall be excluded
from Acquisition Consideration, (iii) amounts in excess of the discounted
present value of payments reasonably anticipated to be made under Contingent
Payment Agreements, the calculation of which is set forth in an officer's
certificate signed by the chief financial officer of the Borrower and delivered
to the Administrative Agent on or prior to the date of such Permitted
Acquisition,

<PAGE>

shall be excluded from Acquisition Consideration; provided that such excluded
payments under Contingent Payment Agreements shall be included in Acquisition
Consideration if actually paid, but shall not create or result in a Default
under Section 6.04(xii) if the amount in such clause is exceeded solely by
virtue of any such excluded payments or a combination thereof, and (iv) in the
event that the Borrower delivers an officer's certificate signed by the chief
financial officer of the Borrower and certifying that specified amounts
previously included in Acquisition Consideration with respect to Contingent
Payment Agreements are not to be paid, then such amounts shall be deducted from
Acquisition Consideration.

                  "Acquisition Corp." means Pharma Services Acquisition Corp., a
North Carolina corporation.

                  "Additional Collateral" shall have the meaning assigned to
such term in Section 5.11.

                  "Adjusted LIBO Rate" means, with respect to any Eurocurrency
Borrowing for any Interest Period, an interest rate per annum (rounded upwards,
if necessary, to the next 1/100 of 1%) equal to (a) the LIBO Rate for such
Interest Period multiplied by (b) the Statutory Reserve Rate.

                  "Administrative Agent" has the meaning assigned to such term
in the preamble hereto.

                  "Administrative Questionnaire" means an Administrative
Questionnaire in the form of Exhibit A.

                  "Affiliate" of any Person means any other Person which,
directly or indirectly, controls, is controlled by or is under common control
with such Person (excluding any trustee under, or any committee with
responsibility for administering, any Plan). A Person shall be deemed to be
"controlled by" any other Person if such other Person possesses, directly or
indirectly, power

                  (a)      to vote 10% or more of the securities (on a fully
         diluted basis) having ordinary voting power for the election of
         directors or managing general partners; or

                  (b)      to direct or cause the direction of the management
         and policies of such Person whether by contract or otherwise.

Each Unrestricted Subsidiary shall be deemed an Affiliate of the Borrower and
its Subsidiaries. Verispan and its Subsidiaries shall be deemed not to be
Affiliates of any Loan Party so long as Verispan is not a Subsidiary of any Loan
Party.

                  "Agent Fees" has the meaning assigned to such term in Section
2.11(c).

                  "Agent Parties" has the meaning assigned to such term in
Section 10.17(c).

                                      -2-

<PAGE>

                  "Agents" means the Administrative Agent and the Collateral
Agent.

                  "Aggregate Foreign Currency Exposure" means the aggregate
amount of the Foreign Currency Lenders' Foreign Currency Exposure.

                  "Aggregate Revolving Credit Exposure" means the aggregate
amount of the Revolving Lenders' Revolving Credit Exposures.

                  "Agreement" has the meaning assigned to such term in the
preamble hereto.

                  "Alternate Base Rate" means for any day, a rate per annum
equal to the highest of (a) the Administrative Agent's Base Rate in effect on
such day, (b) 0.5% per annum above the latest three-week moving average of
secondary market morning offering rates in the United States for three-month
certificates of deposit of major United States money market banks, such
three-week moving average being determined weekly on each Monday (or, if any
such day is not a Business Day, on the next succeeding Business Day) for the
three-week period ending on the next previous Friday by the Administrative Agent
on the basis of such rates reported by certificate of deposit dealers to and
published by the Federal Reserve Bank of New York or, if such publication shall
be suspended or terminated, on the basis of quotations for such rates received
by the Administrative Agent from three New York certificate of deposit dealers
of recognized standing selected by the Administrative Agent, in either case
adjusted to the nearest 0.25% or, if there is no nearest 0.25%, to the next
higher 0.25% (the "Certificate of Deposit Rate"), and (c) the Federal Funds Rate
in effect on such day plus 1/2 of 1%. Any change in the Alternate Base Rate due
to a change in the Base Rate, the Certificate of Deposit Rate or the Federal
Funds Rate shall be effective as of the opening of business on the effective day
of such change in the Base Rate, the Certificate of Deposit Rate or the Federal
Funds Rate, respectively.

                  "Annual Management Payment" has the meaning assigned to such
term in Section 6.07(iv)(b).

                  "Anti-Terrorism Laws" has the meaning assigned to such term in
Section 3.25.

                  "Applicable Currency" has the meaning assigned to such term in
Section 2.13.

                  "Applicable Rate" means, for any day, (i) in the case of
Revolving Loans, the applicable rate per annum as set forth in the table below
under the caption "ABR Revolving Spread," in the case of ABR Revolving Loans and
under the caption "Eurocurrency Revolving Loan Spread," in the case of
Eurocurrency Loans that are Revolving Loans in each case based upon the Total
Leverage Ratio as of the most recent determination date, and (ii) in the case of
Term B Loans that are ABR Loans, 3.25% and in the case of Term B Loans that are
Eurocurrency Loans, 4.25%.

                                      -3-

<PAGE>

<TABLE>
<CAPTION>
         Total               ABR      Eurocurrency
       Leverage           Revolving    Revolving
         Ratio             Spread     Loan Spread
--------------------------------------------------
<S>                       <C>         <C>
> or = 3.5 to 1.00          2.25%       3.25%
--------------------------------------------------
<3.5 to 1.00                2.00%       3.00%
> or = 3.0 to 1.00
--------------------------------------------------
<3.0 to 1.00                1.75%       2.75%
> or = 2.5 to 1.00
--------------------------------------------------
<2.5 to 1.00                1.50%       2.50%
==================================================
</TABLE>

                  For purposes of the foregoing, (i) the Total Leverage Ratio
shall be determined as of the end of each fiscal quarter of the Borrower's
fiscal year based upon the Borrower's consolidated financial statements
delivered pursuant to Section 5.01(a) or (b) and (ii) each change in the
Applicable Rate resulting from a change in the Total Leverage Ratio shall be
effective three (3) Business Days after the date on which the Administrative
Agent shall have received the applicable financial statements and a Compliance
Certificate calculating the Total Leverage Ratio. If at any time the Borrower
has not submitted to the Administrative Agent the applicable information as and
when required under Section 5.01(a) or (b), the Applicable Rate shall be the
highest rate set forth in the table above until such time as the Borrower has
provided the information required under Section 5.01(a) or (b). Within one (1)
Business Day of receipt of the applicable information as and when required under
Section 5.01(a) or (b), the Administrative Agent shall give each Lender
telefacsimile or telephonic notice (confirmed in writing) of the Applicable Rate
in effect from such date.

                  Notwithstanding the foregoing, the Applicable Rate during the
period from the Effective Date until the date that is six months after the
Effective Date (the "Initial Period") shall be determined as if the Total
Leverage Ratio were greater than or equal to 3.5:1.00. At the end of the Initial
Period, the Applicable Rate shall be determined with reference to the last
Compliance Certificate delivered by the Borrower.

                  "Asset Sale" means any direct or indirect sale, transfer,
lease, conveyance or other disposition by the Parent Guarantors, the Borrower or
any of the Restricted Subsidiaries of any of its property or assets, including
any sale or issuance of any Equity Interests of any Subsidiary (including,
without limitation, Equity Interests of an Unrestricted Subsidiary), except (a)
sales, dispositions and leases permitted by Sections 6.05(i), (ii), (iii), (iv),
(v) and (vi), subsection (ii)(A) of Section 6.05(vii) and Sections 6.05(viii)
and (ix) and (b) any such transaction or series of transactions which, if an
Asset Sale, would not generate Net Proceeds in excess of $5.0 million (and, when
taken together with all other such transactions, in excess of $5.0 million in
any twelve-month period).

                  "Assignment and Acceptance" means an assignment and acceptance
entered into by a Lender and an assignee (with the consent of any party whose
consent is required by Section 10.04(b)), and accepted by the Administrative
Agent, in the form of Exhibit C or such other form as shall be approved by the
Administrative Agent.

                                      -4-

<PAGE>

                  "Authorized Officer" means, with respect to the Borrower,
those of its officers whose signature and incumbency have been certified to the
Administrative Agent and the Lenders pursuant to Section 4.01(d) or any
successor thereto.

                  "Available Revolving Credit Commitment" means as to any
Revolving Lender, at any time of determination, an amount equal to such
Revolving Lender's Revolving Credit Commitment at such time minus such Revolving
Lender's Revolving Credit Exposure at such time.

                  "Base Amount" has the meaning assigned to such term in Section
6.16.

                  "Base Rate" means the rate of interest per annum publicly
announced from time to time by the Administrative Agent as its base rate in
effect at its principal office in New York City (the Base Rate not being
intended to be the lowest rate of interest charged by the Administrative Agent
in connection with extensions of credit to debtors) (any change in such rate
announced by the Administrative Agent shall take effect at the opening of
business on the day specified in the public announcement of such change).

                  "Bioglan" means Bioglan Pharmaceuticals Company, a North
Carolina Corporation.

                  "Board" means the Board of Governors of the Federal Reserve
System of the United States.

                  "Borrower" shall have the meaning ascribed to such term in the
preamble to this Agreement.

                  "Borrower's Portion of Excess Cash Flow" means, for any Fiscal
Year, that portion of Excess Cash Flow that the Borrower is not required to
utilize to repay Loans pursuant to Section 2.06(c)(v).

                  "Borrowing" means a Loan or group of Loans to the Borrower of
the same Class and Type made (including through a conversion or continuation) by
the applicable Lenders on a single date and as to which a single Interest Period
is in effect.

                  "Borrowing Date" means any Business Day specified in a notice
pursuant to Section 2.02 or 2.05 as a date on which the Borrower requests Loans
to be made hereunder.

                  "Borrowing Request" has the meaning assigned to such term in
Section 2.02(a).

                  "Business Day" means a day other than a Saturday, Sunday or
other day on which commercial banks in New York, New York are authorized or
required by law to close; provided that (i) when used in connection with a
Eurocurrency Loan, "Business Day" also shall exclude any day on which dealings
in foreign currencies and exchange between banks may not be carried on in
London, England and (ii) when used in connection with a Loan denominated in
Euros, "Business Day" shall also exclude any day on which the TARGET payment
system is not open for the settlement of payments in Euros.

                                      -5-

<PAGE>

                  "Calculation Date" means (a) the last Business Day of each
calendar month and (b) solely with respect to any Foreign Currency Borrowing,
the Business Day immediately preceding the date on which such Borrowing is to be
made.

                  "Capital Expenditures" means, for any period, (a) any and all
expenditures made by the Borrower or any of its Restricted Subsidiaries in such
period for assets added to or reflected in its property, plant and equipment
accounts or other similar capital asset accounts or comparable items or any
other capital expenditures that are, or should be, set forth as "additions to
plant, property and equipment" on the financial statement prepared in accordance
with GAAP, whether such asset is purchased for cash or financed as an account
payable or by the incurrence of Indebtedness, accrued as a liability or
otherwise and (b) all Capital Lease Obligations of the Borrower and its
Restricted Subsidiaries incurred during such period; provided that Capital
Expenditures shall not include expenditures for Permitted PharmaBio Investments
or Permitted Acquisitions.

                  "Capital Lease Obligations" means all monetary or financial
obligations of the Borrower and its Restricted Subsidiaries under any leasing or
similar arrangement conveying the right to use real or personal property, or a
combination thereof, which, in accordance with GAAP, would or should be
classified and accounted for as capital leases, and the amount of such
obligations shall be the capitalized amount thereof determined in accordance
with GAAP and the stated maturity thereof shall be the date of the last payment
of rent or any other amount due under such lease prior to the first date on
which such lease may be terminated by the lessee without payment of a penalty.

                  "CERCLA" means the Comprehensive Environmental Response,
Compensation, and Liability Act of 1980, as amended.

                  "CERCLIS" means the Comprehensive Environmental Response,
Compensation and Liability Information System List.

                  "CGMI" has the meaning assigned to such term in the preamble
hereto.

                  "Change in Control" means (a) prior to a Public Equity
Offering, the Permitted Holders ceasing to own, directly or indirectly, Equity
Interests representing at least a majority of the voting power of the total
outstanding Equity Interests of the Parent; (b) following a Public Equity
Offering, any "person" or "group" (as such terms are used in Sections 13(d) and
14(d) of the Exchange Act), other than one or more Permitted Holders, is or
becomes the beneficial owner (as defined in Rules 13d-3 and 13d-5 under the
Exchange Act, except that for purposes of this clause that person or group shall
be deemed to have "beneficial ownership" of all securities that that person or
group has the right to acquire, whether such right is exercisable immediately or
only after the passage of time), directly or indirectly, of Equity Interests
representing more than 35% of the voting power of the total outstanding Equity
Interests of the Parent, and the Permitted Holders shall at such time own a
lower percentage of the voting power of the total outstanding Equity Interests
of the Parent and shall not have at such time the right or ability by voting
power, contract or otherwise to elect or designate for election a majority of
the board of directors of the Parent; (c) following a Public Equity Offering,
occupation of a majority of the

                                      -6-

<PAGE>

seats (other than vacant seats) on the board of directors of the Parent by
Persons who were neither (i) nominated by the board of directors of the Parent
nor (ii) appointed by directors so nominated; (d) at any time, the Parent shall
cease to own directly 100% of the outstanding Equity Interests of the
Intermediate Parent or the Parent shall cease to own directly or indirectly 100%
of the outstanding Equity Interests of the Borrower; or (e) the occurrence of a
"change of control" under the Subordinated Notes Indenture, any Permitted
Discount Notes or any Permitted Subordinated Indebtedness.

                  "Charges" has the meaning assigned to such term in Section
10.09.

                  "Class" when used in reference to any Loan or Borrowing,
refers to whether such Loan, or the Loans comprising such Borrowing, are
Revolving Loans, Term B Loans, Foreign Currency Loans or Swingline Loans, and
when used in reference to any Commitment, refers to whether such Commitment is a
Revolving Credit Commitment or Term B Commitment, and when used in reference to
any Lender, refers to whether such Lender is a Revolving Lender or a Term B
Lender.

                  "Closing Certificate" means a certificate substantially in the
form of Exhibit G.

                  "Code" means the Internal Revenue Code of 1986, as amended
from time to time.

                  "Collateral" means any and all "Collateral," "Mortgaged
Property" or "Trust Property," as defined in any applicable Security Document.

                  "Collateral Account" means the collateral account or
sub-account established and maintained by the Collateral Agent in its name as
Collateral Agent for the benefit of the Secured Parties, in accordance with the
provisions of the Security Agreement.

                  "Collateral Agent" means Citicorp North America, Inc., in its
capacity as collateral agent for the Secured Parties under the Security
Documents.

                  "Collateral Sharing Agreement" means the Collateral Sharing
Agreement, substantially in the form of Exhibit D, between the Borrower and the
Collateral Agent for the benefit of the Secured Parties.

                  "Commitment" means, with respect to any Lender, such Lender's
Revolving Credit Commitment or Term B Commitment or any combination thereof (as
the context requires).

                  "Commitment Fee" has the meaning assigned to such term in
Section 2.11(a).

                  "Commitment Fee Average Daily Amount" has the meaning assigned
to such term in Section 2.11(a).

                  "Commitment Fee Termination Date" has the meaning assigned to
such term in Section 2.11(a).

                                      -7-

<PAGE>

                  "Commitment Letter" means the Commitment Letter dated April
10, 2003 among the Administrative Agent, the Lead Arranger, the Parent, OEP and
GF Management Company LLC.

                  "Commitment Percentage" means the percentage of the Total
Revolving Credit Commitment represented by such Lender's Revolving Credit
Commitment. If the Revolving Credit Commitments have terminated or expired, the
Commitment Percentage shall be determined based upon the Revolving Credit
Commitments most recently in effect, giving effect to any assignments.

                  "Communications" has the meaning assigned to such term in
Section 10.17(a).

                  "Compliance Certificate" has the meaning assigned to such term
in Section 5.01(b) and shall be substantially in the form of Exhibit E.

                  "Consolidated EBITDA" means, for any period, Consolidated Net
Income for such period plus (a) without duplication and to the extent deducted
in determining or otherwise reducing such Consolidated Net Income (in each case,
other than to the extent attributable to Unrestricted Subsidiaries), the sum of
(i) Consolidated Interest Expense less cash interest income actually received
for such period, (ii) consolidated income tax expense for such period, (iii) all
amounts properly attributable to depreciation, amortization and non-cash
reductions of revenues in connection with Permitted PharmaBio Investments for
such period, (iv) any non-cash deductions from Consolidated Net Income for such
period due to the write-down of any assets or any non-recurring event (other
than any deductions which require or represent the accrual of a reserve for the
payment of cash charges in any future period or amortization of a prepaid cash
expense that was paid in a prior period), (v) extraordinary losses for such
period and any losses realized in connection with any sale or disposition of
assets outside the ordinary course of business during such period (other than
Permitted PharmaBio Investments), (vi) with respect to any disposition of a
Permitted PharmaBio Investment during such period, any previous write-up of the
value of such Permitted PharmaBio Investment that is not otherwise included (and
has not been previously included) in Consolidated EBITDA, (vii) restructuring
charges related to the Transactions that are incurred within one year of the
Effective Date, fees and expenses (including legal, accounting, debt issuance
costs) paid in connection with the Transactions and (viii) severance payments
and charges as a result of the Merger pursuant to employment agreements existing
on the Effective Date paid within 18 months of the Effective Date and any
payments made or charges in lieu of or as a replacement for such severance
payments (including retention payments paid or expenses as an incentive to
retained employees and severance payments allocated to non-competition
provisions contained in such employment agreements) so long as (A) such
replacement payments are actually made within 18 months of the Effective Date or
allocated to a non-competition provision entered into within 18 months after the
Effective Date and (B) the total replacement payments plus any severance
payments made to any Person does not exceed the amount of severance payments
originally due, minus (b) without duplication and to the extent included in
determining such Consolidated Net Income, any (i) extraordinary gains for such
period and any gains realized in connection with any sale or disposition of
assets outside the ordinary course of business (other than Permitted PharmaBio
Investments) during such period,

                                      -8-

<PAGE>

(ii) any non-cash additions to Consolidated Net Income during such period due to
the write-up of any assets or any non-recurring event and (iii) any amounts paid
by the Borrower directly or indirectly to the Parent pursuant to Section
6.07(iv), all determined on a consolidated basis in accordance with GAAP. For
purposes of determining compliance with Sections 6.13 through 6.15 only, (x) if
Consolidated EBITDA is being calculated for Test Periods including one or more
Fiscal Quarters during the Cymbalta Ramp Up Period, Consolidated EBITDA shall be
calculated to exclude Net Cymbalta Expenses during such Fiscal Quarters not to
exceed (A) $25.0 million per Fiscal Quarter and (B) $125.0 million in the
aggregate and (y) calculations of Consolidated EBITDA of the Borrower and its
Restricted Subsidiaries for periods prior to the Effective Date shall be
determined on a pro forma basis to give effect to the consummation of the
Transactions as if they occurred on the first day of such period.

                  "Consolidated Indebtedness" means, at a particular date, the
aggregate stated balance sheet amount of all Indebtedness of the Borrower and
its Restricted Subsidiaries determined on a consolidated basis in accordance
with GAAP at such date. For purposes of determining compliance with Sections
6.14 and 6.15 only, Consolidated Indebtedness as of the last day of a Test
Period shall be reduced by the amount of cash (not to exceed $50.0 million in
the aggregate) of the Borrower and its Restricted Subsidiaries shown on a
consolidated balance sheet in accordance with GAAP as of the last day of such
Test Period.

                  "Consolidated Interest Expense" means, with respect to the
Borrower and its Restricted Subsidiaries on a consolidated basis for any period,
the sum of (a) gross interest expense for such period, including (i) the
amortization of debt discounts, (ii) the amortization of all fees (including
fees with respect to Hedging Agreements) payable in connection with the
incurrence of Indebtedness to the extent included in interest expense and (iii)
the portion of any payments or accruals with respect to Capital Lease
Obligations allocable to interest expense, and (b) capitalized interest.

                  "Consolidated Net Income" means, for any period, the net
income or loss of the Borrower and its Restricted Subsidiaries for such period
determined on a consolidated basis in accordance with GAAP; provided that (i)
the income or loss of any Person (other than consolidated Restricted
Subsidiaries of the Borrower) in which any other Person (other than the Borrower
or any of its Restricted Subsidiaries) has a joint interest shall be excluded
therefrom, except to the extent of the amount of dividends or other
distributions actually paid to the Borrower or any of its Restricted
Subsidiaries by such Person during such period, which shall be included in
Consolidated Net Income for such period, (ii) the cumulative effect of a change
in accounting principles during such period shall be excluded therefrom, (iii)
any net after-tax income (loss) from discontinued operations and any net
after-tax gains or losses on disposal of discontinued operations shall be
excluded therefrom, (iv) the income or loss of any Person accrued prior to the
date it becomes a Restricted Subsidiary or is merged into or consolidated with
the Borrower or any of its Restricted Subsidiaries or that Person's assets are
acquired by the Borrower or any of its Restricted Subsidiaries shall be excluded
therefrom, (v) the income of any consolidated Restricted Subsidiary shall be
excluded therefrom to the extent that declaration of payment of both dividends
or similar distributions by that Restricted Subsidiary of that income is not at
the time permitted by operation of the terms of its charter or any agreement,
instrument, judgment, de-

                                      -9-

<PAGE>

cree, order, statute, rule or governmental regulation applicable to that
Restricted Subsidiary and (vi) for purposes of calculating Consolidated Net
Income in any period, purchase price allocation adjustments to the balance sheet
and amortization of any purchase price allocation adjustments, in each case
related to the Merger, shall be excluded and as such considered to be zero.

                  "Consolidated Operating Assets" means, with respect to any
Person as at any date of determination, the total assets of such Person and its
Restricted Subsidiaries which should properly be classified as operating assets
in the calculation of changes in operating assets on a consolidated statement of
cash flows of such Person and its Restricted Subsidiaries in accordance with
GAAP.

                  "Consolidated Operating Liabilities" means, with respect to
any Person as at any date of determination, the total liabilities of such Person
and its Restricted Subsidiaries which should properly be classified as operating
liabilities in the calculation of changes in operating liabilities on a
consolidated statement of cash flows of such Person and its Restricted
Subsidiaries in accordance with GAAP.

                  "Contested Collateral Lien Conditions" means (a) any
proceeding instituted contesting such Lien shall conclusively operate to stay
the sale or forfeiture of any portion of the Collateral on account of such Lien;
and (b) in the event the amount of any such Lien shall exceed $5.0 million and
shall not be fully covered by insurance (less any deductible) as to which the
insurer has acknowledged responsibility to pay and discharge such Lien, the Loan
Party or its applicable Subsidiary shall either obtain a bond or maintain cash
reserves, in either case, in an amount sufficient to pay and discharge such Lien
and the Collateral Agent's reasonable estimate of all interest and penalties
related thereto.

                  "Contingent Payment Agreements" has the meaning assigned to
such term in the definition of "Acquisition Consideration."

                  "control" means the possession, directly or indirectly, of the
power to direct or cause the direction of the management or policies of a
person, whether through the ownership of voting securities, by contract or
otherwise, and "controlling" and "controlled" have meanings correlative thereto.

                  "CPI Increase Amount" means with respect to any calendar year
an amount equal to the Annual Management Payment permitted to be paid under
Section 6.07(iv)(b) and 6.08(v)(b) for the prior calendar year times the
percentage of the increase from such preceding calendar year in the Urban Wage
Earners and Clerical Workers Consumer Price Index for the New York Metropolitan
Area, such amount to be calculated in March of each year, beginning in March
2005.

                  "Credit Event" has the meaning assigned to such term in
Section 4.02.

                  "Cumulative Consolidated Net Income" means 50% of the
cumulative Consolidated Net Income (or if such cumulative Consolidated Net
Income shall be a loss, minus 100% of such loss) of the Borrower and its
Restricted Subsidiaries since the beginning of the first com-

                                      -10-

<PAGE>

plete Fiscal Quarter beginning after the Effective Date to the end of the last
fiscal period for which financial statements have been provided to the Lenders
pursuant to Section 5.01(a) or (b).

                  "Cumulative Excess Cash Flow" means the sum of (A) for each
Fiscal Year beginning after December 31, 2003, (a) 50% of the Borrower's Portion
of Excess Cash Flow for such Fiscal Year if the Total Leverage Ratio for the
Test Period ending as of the end of such Fiscal Year is greater than or equal to
3.25x or (b) 100% of the Borrower's Portion of Excess Cash Flow for such Fiscal
Year if the Total Leverage Ratio for the Test Period ending as of the end of
such Fiscal Year is less than 3.25x, less (B) if Excess Cash Flow is less than
zero for any Fiscal Year beginning after December 31, 2003, 100% of such
negative Excess Cash Flow.

                  "Currency of Payment" has the meaning assigned to such term in
Section 10.19.

                  "Cymbalta(TM) Launch" means the commencement by the Borrower
of its commercialization efforts for Cymbalta(TM) in the United States, pursuant
to an agreement entered into in July 2002 with Eli Lilly and Company.

                  "Cymbalta(TM) Ramp Up Period" means the period from the first
day of the first Fiscal Quarter in which the Borrower and its Restricted
Subsidiaries expend cash amounts in excess of $10.0 million during such Fiscal
Quarter relating to the Cymbalta(TM) Launch (net of all royalties relating to
Cymbalta(TM) and net of other fees from Eli Lilly received by the Borrower or
its Restricted Subsidiaries with respect to Cymbalta(TM) during such Fiscal
Quarter) to and including the last day of the sixth Fiscal Quarter after such
Fiscal Quarter.

                  "Debt Incurrence" has the meaning assigned to such term in
Section 2.06(c)(ii).

                  "Default" means any Event of Default, any Event of Termination
and any event or condition which upon notice, lapse of time or both would
constitute an Event of Default or Event of Termination.

                  "Default Rate" has the meaning assigned to such term in
Section 2.09(c)(ii).

                  "Designated Asian Subsidiary" means (i) any Non-U.S.
Subsidiary organized in and operating primarily in India, Japan or Korea and
identified as a Designated Asian Subsidiary either on Schedule 6.04 or by
subsequent written notice to the Administrative Agent and (ii) any Non-U.S.
Subsidiary that is a holding company and that has as its only asset Equity
Interests of a Non-U.S. Subsidiary identified in clause (i).

                  "Destruction" means any and all damage to, or loss or
destruction of, or loss of title to, all or any portion of the Property of the
Parent Guarantors, the Borrower or any of the Restricted Subsidiaries.

                  "DG Equity Rollover" means the retention of $95,200,000 in
aggregate amount of Equity Interests in the Borrower by Dr. Dennis B. Gillings
and his affiliates and selected shareholders of the Borrower including directors
and members of senior management in connection with the Merger; provided,
however, that not less than 5,862,068 shares of the Borrower's com-

                                      -11-

<PAGE>

mon stock held by Dr. Gillings and his affiliates and all options to purchase
shares of Borrower's common stock held by Dr. Gillings will be delivered to the
Parent in exchange for Equity Interests of the Parent.

                  "DG Equity Rollover Agreement" means the rollover agreement,
dated as of August 28, 2003, as amended, by and among the Parent, Dr. Dennis B.
Gillings, Joan H. Gillings, Susan Ashley Gillings, the Gillings Family
Foundation, the Gillings Family Limited Partnership and the GFEF Limited
Partnership.

                  "Documentation Agent" has the meaning assigned to such term in
the preamble hereto.

                  "Dollar Equivalent" means, on any date of determination, (a)
with respect to any amount in Dollars, such amount and (b) with respect to any
amount in Pounds Sterling or Euros, the equivalent in Dollars of such amount,
determined by the Administrative Agent pursuant to Section 1.04 using the
Exchange Rate with respect to either Pounds Sterling or Euros, as the case may
be, at the time in effect under the provisions of such Section.

                  "Dollar Portion" has the meaning provided for such term in
Section 2.04.

                  "Dollars" or "$" means lawful money of the United States of
America.

                  "Domestic Subsidiary" means any Restricted Subsidiary of the
Borrower that is not a Non-U.S. Subsidiary.

                  "Effective Date" means the date on which the conditions
specified in Section 4.01 are satisfied (or waived in accordance with Section
10.08).

                  "Embargoed Person" has the meaning assigned to such term in
Section 6.19.

                  "EMU Legislation" means the legislative measures of the
European Union for the introduction of, change over to or operation of the Euro
in one or more member states.

                  "Environment" means ambient air, surface water and groundwater
(including potable water, navigable water and wetlands), the land surface or
subsurface strata, natural resources such as flora and fauna, or as otherwise
defined in any applicable Environmental Law.

                  "Environmental Claim" means any written accusation,
allegation, notice of violation, claim, demand, order, directive, cost recovery
action or other cause of action by, or on behalf of, any Governmental Authority
or any other Person for damages, injunctive or equitable relief, personal injury
(including sickness, disease or death), Remedial Action costs, tangible or
intangible property damage, natural resource damages, nuisance, pollution, any
adverse effect on the Environment caused by any Hazardous Material, or for
fines, penalties or restrictions, resulting from or based upon: (a) the
existence, or the continuation of the existence, of a Release (including sudden
or non-sudden, accidental or non-accidental Releases); (b) exposure to any
Hazardous Material; (c) the presence, use, handling, transportation, storage,
treatment or disposal of

                                      -12-

<PAGE>

any Hazardous Material; or (d) the violation or alleged violation of any
Environmental Law or Environmental Permit.

                  "Environmental Laws" means any and all applicable treaties,
laws (including common law), rules, regulations, codes, ordinances, orders,
decrees, judgments, injunctions or binding agreements issued, promulgated or
entered into by any Governmental Authority, relating in any way to the
Environment, preservation or reclamation of natural resources, the management,
Release or threatened Release of, or exposure to, any Hazardous Material or to
health and safety matters.

                  "Environmental Liability" means any liability, contingent or
otherwise (including, but not limited to, any liability for damages, natural
resource damage, costs of environmental remediation, administrative oversight
costs, fines, penalties or indemnities), of the Parent Guarantors, the Borrower
or any of their Subsidiaries directly or indirectly resulting from or based upon
(a) violation of any Environmental Law, (b) the generation, use, handling,
transportation, storage, treatment or disposal of any Hazardous Materials, (c)
exposure to any Hazardous Materials or (d) the Release or threatened Release of
any Hazardous Materials into the Environment.

                  "Environmental Permit" means any permit, approval,
authorization, certificate, license, variance, filing or permission required by
or from any Governmental Authority pursuant to any Environmental Law.

                  "Equity Interests" means shares of capital stock, partnership
interests, membership interests in a limited liability company, beneficial
interests in a trust or other equity ownership interests in a Person.

                  "Equity Investments" means the OEP Equity Investment and the
DG Equity Rollover.

                  "Equity Issuance" has the meaning assigned thereto in Section
2.06(c)(i).

                  "Equity Rights" means all securities convertible or
exchangeable for Equity Interests and all warrants, options or other rights to
purchase or subscribe for any Equity Interests, whether or not presently
convertible, exchangeable or exercisable.

                  "ERISA" means the Employee Retirement Income Security Act of
1974, as the same may be amended from time to time.

                  "ERISA Affiliate" means any trade or business (whether or not
incorporated) that, together with any Loan Party, is treated as a single
employer under Section 414(b) or (c) of the Code, and for the purpose of Section
302 of ERISA and/or Section 412, 4971, 4977, 4980D, 4980E and/or each
"applicable section" under Section 414(t)(2) of the Code, within the meaning of
Section 414(b), (c), (m) or (o) of the Code.

                  "ERISA Event" means (a) any "reportable event," as defined in
Section 4043(c) of ERISA or the regulations issued thereunder, with respect to a
Pension Plan (other than an

                                      -13-

<PAGE>

event for which the 30-day notice period is waived by regulation); (b) the
existence with respect to any Pension Plan of an "accumulated funding
deficiency" (as defined in Section 412 of the Code or Section 302 of ERISA),
whether or not waived, the failure to make by its due date a required
installment under Section 412(m) of the Code with respect to any Pension Plan or
the failure to make any required contribution to a Multiemployer Plan; (c) the
filing pursuant to Section 412(d) of the Code or Section 303(d) of ERISA of an
application for a waiver of the minimum funding standard with respect to any
Pension Plan; (d) the incurrence by any Loan Party or ERISA Affiliate of any
liability under Title IV of ERISA with respect to any Pension Plan; (e) the
receipt by any Loan Party or ERISA Affiliate from the PBGC or a plan
administrator of any notice relating to an intention to terminate any Pension
Plan, to appoint a trustee to administer any Pension Plan, or to take any other
action with respect to a Pension Plan that could result in material liability to
a Loan Party or a Subsidiary, or the occurrence of any event or condition which
could reasonably be expected to constitute grounds under ERISA for the
termination of or the appointment of a trustee to administer, any Pension Plan;
(f) the incurrence by any Loan Party or ERISA Affiliate of any liability with
respect to the withdrawal or partial withdrawal from any Pension Plan or
Multiemployer Plan; (g) the receipt by a Loan Party or ERISA Affiliate of any
notice concerning the imposition of Withdrawal Liability or a determination that
a Multiemployer Plan is, or is expected to be, insolvent or in reorganization,
within the meaning of Title IV of ERISA; (h) the making of any amendment to any
Pension Plan which could result in the imposition of a lien or the posting of a
bond or other security; or (i) the occurrence of a nonexempt prohibited
transaction (within the meaning of Section 4975 of the Code or Section 406 of
ERISA) which could result in liability to a Loan Party or any of the
Subsidiaries.

                  "Euro" or "E" means the single currency of the European
Union as constituted by the treaty of European Union and as referred to in the
EMU Legislation.

                  "Eurocurrency Borrowing" means a Borrowing comprised of
Eurocurrency Loans.

                  "Eurocurrency Loan" means any Loan bearing interest at a rate
determined by reference to the Adjusted LIBO Rate in accordance with the
provisions of Article II.

                  "Eurocurrency Revolving Credit Borrowing" means a Revolving
Credit Borrowing or Foreign Currency Borrowing comprised of Eurocurrency Loans.

                  "Event of Default" has the meaning assigned to such term in
Section 7.01.

                  "Event of Termination" has the meaning assigned to such term
in Section 7.01.

                  "Excess Cash Flow" means, without duplication, for any Person
for any period for which such amount is being determined:

                  (a)      Consolidated Net Income (exclusive of any non-cash
         write-up of assets and inclusive of any non-cash write-down of assets
         and without giving effect to clause (iii) of the definition thereof
         with respect to any cash net after-tax income from discontinued
         operations or after-tax gain on disposal of discontinued operations)
         adjusted

                                      -14-

<PAGE>

         to (A) exclude any amount of gain included in both (x) Consolidated Net
         Income and (y) Net Proceeds actually applied to the prepayment of the
         Loans pursuant to Section 2.06(c)(iii) or (iv); and (B) include the
         gain on any sale or disposition of a Permitted PharmaBio Investment to
         the extent not already included in Consolidated Net Income; plus

                  (b)      the amount of depreciation, amortization of
         intangibles, deferred taxes (which may be positive or negative for this
         purpose) and other non-cash expenses and non-cash amortization of
         revenues received in connection with Permitted PharmaBio Investments
         which, pursuant to GAAP, were deducted in determining such Consolidated
         Net Income of such Person; plus

                  (c)      the amount by which working capital for such period
         decreased (i.e., the decrease in Consolidated Operating Assets
         (excluding cash and Permitted Investments) of such Person minus
         Consolidated Operating Liabilities (excluding (A) changes in current
         liabilities for borrowed money and (B) cash or Permitted Investments
         which are Net Proceeds required to be applied to the prepayment of the
         Loans pursuant to Section 2.06(c)) of such Person from the beginning to
         the end of such period); minus

                  (d)      the amount by which working capital for such period
         increased (i.e., the increase in Consolidated Operating Assets
         (excluding cash and Permitted Investments) of such Person minus
         Consolidated Operating Liabilities (excluding (A) changes in current
         liabilities for borrowed money and (B) cash or Permitted Investments
         which are Net Proceeds required to be applied to the prepayment of the
         Loans pursuant to Section 2.06(c)) of such Person from the beginning to
         the end of such period); minus

                  (e)      the amount of Capital Expenditures that are paid from
         internally generated funds in such period; minus

                  (f)      payments of principal under the Term B Loans on the
         Installment Payment Dates pursuant to Section 2.06(d) made during such
         period; minus

                  (g)      scheduled payments of principal of Indebtedness
         permitted to be incurred under Section 6.01(a)(iii) to the extent such
         payment is made from internally generated funds; minus

                  (h)      optional prepayments of principal under the Term B
         Loans from internally generated funds made during such period; minus

                  (i)      the amount of any increase (but not any decrease) in
         advances from customers accounted for as unearned income in accordance
         with GAAP.

                  "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

                  "Exchange Rate" means, on any day, for purposes of determining
the Dollar Equivalent of any other currency, the rate at which such other
currency may be exchanged into

                                      -15-

<PAGE>

Dollars, as set forth at approximately 11:00 a.m., London time, on such day on
the Telerate Page for such currency. In the event that such rate does not appear
on any Telerate Page, the Exchange Rate shall be determined by reference to such
other publicly available service for displaying exchange rates as may be agreed
upon by the Administrative Agent and the Borrower or, in the absence of such an
agreement, such Exchange Rate shall instead be the arithmetic average of the
spot rates of exchange of the Administrative Agent in the market where its
foreign currency exchange operations in respect of such currency are then being
conducted, at or about 10:00 a.m., local time, on such date for the purchase of
Dollars for delivery two Business Days later; provided that if at the time of
any such determination, for any reason, no such spot rate is being quoted, the
Administrative Agent may use any reasonable method it deems appropriate to
determine such rate, and such determination shall be presumed correct in the
absence of facts or circumstances indicating that it has been made in error.

                  "Excluded Debt Issuance" means any issuance of Indebtedness
permitted by Section 6.01(a) (other than Section 6.01(a)(xvi)).

                  "Excluded Equity Issuance" means the issuance of Equity
Interests or Equity Rights of the Parent in the ordinary course to directors,
officers or employees of the Borrower or its Subsidiaries.

                  "Executive Order" has the meaning assigned to such term in
Section 3.25 and Section 6.19.

                  "Facilities" has the meaning assigned to such term in Section
10.16(a).

                  "Federal Funds Rate" means, for any day, the weighted average
of the rates (rounded upwards, if necessary, to the nearest 1/100th of 1%) on
overnight federal funds transactions with members of the Federal Reserve System
arranged by federal funds brokers, as published on the next succeeding Business
Day by the Federal Reserve Bank of New York; provided that (a) if the day for
which such rate is to be determined is not a Business Day, the Federal Funds
Rate for such day shall be such rate for such transactions on the next preceding
Business Day as so published on the next succeeding Business Day, and (b) if
such rate is not so published for any day which is a Business Day, the Federal
Funds Rate for such day shall be the average of the quotations for the day of
such transactions received by the Administrative Agent from three federal funds
brokers of recognized standing selected by it.

                  "Fee Agreement" means the Fee Agreement, dated as of August
28, 2003, among the Parent, OEP and Dennis B. Gillings, governing the payment by
the Parent of OEP's and Dennis B. Gillings' and their respective Affiliates fees
and expenses related to the Merger.

                  "Fee Letter" means the Fee Letter dated April 10, 2003 among
the Administrative Agent, the Lead Arranger, GF Management Company, LLC, OEP and
the Parent.

                  "Fees" means the Commitment Fees, the LC Fees and the Agent
Fees.

                                      -16-
<PAGE>

                  "Financial Officer" of any corporation, partnership or other
entity means the chief financial officer, the principal accounting officer,
Treasurer or Controller of such corporation, partnership or other entity.

                  "Fiscal Quarter" means any quarter of a Fiscal Year.

                  "Fiscal Year" means any period of twelve consecutive calendar
months ending on December 31; references to a Fiscal Year with a number
corresponding to any calendar year (e.g., the "2003 Fiscal Year") refer to the
Fiscal Year ending on December 31 occurring during such calendar year.

                  "Foreign Currency Borrowing" means Foreign Currency Loans made
on the same day by the Foreign Currency Lenders ratably according to their
respective Foreign Currency Sublimits then in effect.

                  "Foreign Currency Exposure" means, with respect to any Foreign
Currency Lender at any time, the Dollar Equivalent of the aggregate principal
amount of all Foreign Currency Loans made by such Foreign Currency Lender and
outstanding at such time. The Foreign Currency Exposure of any Revolving Lender
at any time shall be the sum of (without duplication) (A) its Commitment
Percentage of the Foreign Currency Exposure of all Foreign Currency Lenders at
such time and (B) the Foreign Currency Exposure of all Foreign Currency Lenders
that has been converted into Revolving Dollar Loans pursuant to Section 2.04 and
in respect of which such Revolving Lender has made, or is required to make,
payments to the Foreign Currency Lenders under such Section 2.04.

                  "Foreign Currency Intercompany Notes" means any promissory
note made by any Non-U.S. Subsidiary of the Borrower, as intercompany borrower,
to the Borrower, evidencing all advances made with proceeds of Loans to such
Non-U.S. Subsidiary by the Borrower from time to time, in form and substance
reasonably satisfactory to the Administrative Agent.

                  "Foreign Currency Lender" means the Revolving Lender (or
Affiliate of a Revolving Lender) identified on Schedule 2.01 on the date hereof
as a "Foreign Currency Lender" with the Foreign Currency Sublimit set forth
thereon and any other Revolving Lender that (a) agrees, with the approval of the
Administrative Agent and the Borrower, which approval shall not be unreasonably
withheld (provided, however, that after the occurrence and during the
continuance of any Default or Event of Default, such approval by the Borrower
shall not be required), to act, or cause one of its Affiliates to act, as a
Foreign Currency Lender with a Foreign Currency Sublimit agreed to by the
Administrative Agent and the Borrower (provided, however, that no Revolving
Lender or Affiliate thereof shall become a Foreign Currency Lender to the
extent, after giving effect to such Revolving Lender or Affiliate thereof
becoming a Foreign Currency Lender with the proposed Foreign Currency Sublimit,
the aggregate Foreign Currency Sublimit amount would exceed the Maximum Foreign
Currency Sublimit) and (b) whether directly or through an Affiliate thereof, at
the time of such agreement by such Foreign Currency Lender, can, on its own,
make Foreign Currency Loans to the Borrower the interest payments with respect
to which can be made free of withholding taxes.

                                      -17-

<PAGE>

                  "Foreign Currency Loans" means the Revolving Loans made by the
Revolving Lender in Pounds Sterling or Euros pursuant to clause (iii) of the
first sentence of Section 2.01(a).

                  "Foreign Currency Ratable Portion" means, with respect to any
Foreign Currency Lender (a) at any time prior to the reduction of the Foreign
Currency Sublimits to zero, the percentage obtained by dividing (i) the Foreign
Currency Sublimit of such Lender in effect at such time by (ii) the aggregate
Foreign Currency Sublimits of all Foreign Currency Lenders in effect at such
time and (b) at any time thereafter, the percentage obtained by dividing (i) the
aggregate outstanding principal amount of all Foreign Currency Loans outstanding
at such time and owing to such Foreign Currency Lender by (ii) the aggregate
outstanding principal amount of all Foreign Currency Loans outstanding at such
time.

                  "Foreign Currency Sublimit" means, with respect to each
Foreign Currency Lender, the Dollar amount set forth opposite such Foreign
Currency Lender's name on Schedule 2.01 under the caption "Foreign Currency
Sublimit," as amended to reflect each Assignment and Acceptance executed by such
Foreign Currency Lender and as such amount may be reduced pursuant to this
Agreement. The aggregate Foreign Currency Sublimits on the Effective Date shall
be the Maximum Foreign Currency Sublimit.

                  "Foreign Excess Cash Flow" shall mean the Excess Cash Flow of
the Non-U.S. Restricted Subsidiaries determined on a consolidated basis as if a
separate consolidated group, without regard to the Borrower or the Domestic
Subsidiaries.

                  "Foreign Plan" means any employee benefit plan, program,
policy, arrangement or agreement maintained or contributed to outside the United
States by any Loan Party or any Subsidiary primarily for the benefit of
employees of any Loan Party or any Subsidiary employed outside the United
States.

                  "GAAP" means generally accepted accounting principles in the
United States applied on a consistent basis.

                  "Governmental Authority" means any Federal, state, local or
foreign court or governmental agency, authority, instrumentality or regulatory
body, including any central bank.

                  "Guarantee" of or by any Person (the "guarantor") means any
obligation, contingent or otherwise, of the guarantor guaranteeing or having the
economic effect of guaranteeing any Indebtedness or other obligation of any
other Person (the "primary obligor") in any manner, whether directly or
indirectly, and including any obligation of the guarantor, direct or indirect,
(a) to purchase or pay (or advance or supply funds for the purchase or payment
of) such Indebtedness or other obligation or to purchase (or to advance or
supply funds for the purchase of) any security for the payment thereof, (b) to
purchase or lease property, securities or services for the purpose of assuring
the owner of such Indebtedness or other obligation of the payment thereof
(including pursuant to a "synthetic lease"), (c) to maintain working capital,
equity capital or any other financial statement condition or liquidity of the
primary obligor so as to enable the primary obligor to pay such Indebtedness or
other obligation or (d) as an account party in respect of any

                                      -18-

<PAGE>

letter of credit or letter of guaranty issued to support such Indebtedness or
obligation; provided that the term "Guarantee" shall not include endorsements
for collection or deposit in the ordinary course of business. The amount of the
obligation under any Guarantee shall be deemed to be the lower of (a) an amount
equal to the stated or determinable amount of the primary obligation in respect
of which such Guarantee is made (including principal, interest and fees) and (b)
the maximum amount for which such guarantor may be liable pursuant to the terms
of the instrument embodying such Guarantee, unless such primary obligation and
the maximum amount for which such guarantor may be liable are not stated or
determinable, in which case the amount of the obligation under such Guarantee
shall be such guarantor's maximum reasonably anticipated liability in respect
thereof as determined by the guarantor in good faith; irrespective, in any such
case, of any amount thereof that would, in accordance with GAAP, be required to
be reflected on a balance sheet of such Person.

                  "Guarantee Agreement" means the Subsidiary Guarantee
Agreement, substantially in the form of Exhibit H, made by the Domestic
Subsidiaries in favor of the Administrative Agent for the benefit of the Secured
Parties.

                  "Hazardous Materials" means all pollutants, contaminants,
wastes, substances, chemicals, materials and constituents, including without
limitation, crude oil, petroleum or petroleum distillates, asbestos or
asbestos-containing materials, polychlorinated biphenyls ("PCBs") or
PCB-containing materials or equipment of any nature which can give rise to
Environmental Liability under, or are regulated pursuant to, any Environmental
Law.

                  "Hedging Agreement" means any interest rate protection
agreement, foreign currency exchange agreement, commodity price protection
agreement or other interest or currency exchange rate or commodity price hedging
arrangement and all other similar agreements or arrangements designed to alter
the risks of any Person arising from fluctuations in interest rate, currency
values or commodity prices.

                  "Impermissible Qualification" means, relative to the opinion
or certification of any independent public accountant as to any financial
statement of the Borrower, any qualification or exception to such opinion or
certification:

                  (a)      which is of a "going concern" or similar nature;

                  (b)      which relates to the limited scope of examination of
         matters relevant to such financial statement; or

                  (c)      which relates to the treatment or classification of
         any item in such financial statement and which, as a condition to its
         removal, would require an adjustment to such item the effect of which
         would be to cause the Borrower to be in default of any of its
         obligations under any of Sections 6.13 through 6.16, inclusive.

                  "Increased Cost Lender" has the meaning assigned thereto in
Section 2.21.

                                      -19-

<PAGE>

                  "Indebtedness" of any Person means, without duplication, (a)
all obligations of such Person for borrowed money or with respect to deposits or
advances of any kind, (b) all obligations of such Person evidenced by bonds,
debentures, notes or similar instruments, (c) all obligations of such Person
upon which interest charges are customarily paid (excluding obligations to pay
salary or benefits under deferred compensation or other benefit programs), (d)
all obligations of such Person under conditional sale or other title retention
agreements (excluding the deferred purchase price of Permitted PharmaBio
Investments) relating to property acquired by such Person, (e) all obligations
of such Person in respect of the deferred purchase price of property or services
(excluding the deferred purchase price of Permitted PharmaBio Investments and
current accounts payable incurred in the ordinary course of business), (f) all
Indebtedness (excluding prepaid interest thereon) of others secured by (or for
which the holder of such Indebtedness has an existing right, contingent or
otherwise, to be secured by) any Lien on property owned or acquired by such
Person, whether or not the Indebtedness secured thereby has been assumed, (g)
all Guarantees by such Person of Indebtedness or other monetary or financial
obligations of others, (h) all Capital Lease Obligations of such Person, (i) all
payments that such Person would have to make in the event of an early
termination, on the date Indebtedness of such Person is being determined, in
respect of outstanding interest rate protection agreements, foreign currency
exchange agreements or other interest or exchange rate hedging arrangements, (j)
all obligations, contingent or otherwise, of such Person as an account party in
respect of letters of credit and letters of guaranty and (k) all obligations,
contingent or otherwise, of such Person in respect of bankers' acceptances,
surety bonds and performance bonds, whether or not matured. The Indebtedness of
any Person shall include the Indebtedness of any other entity (including any
partnership in which such Person is a general partner) to the extent such Person
is directly liable therefor as a result of such Person's ownership interest in
or other relationship with such entity, except to the extent the terms of such
Indebtedness provide that such Person is not liable therefor. Notwithstanding
the foregoing, Indebtedness shall not (i) include obligations to provide
services, including without limitation, the provisions of sales force personnel
and related expenses, arising pursuant to agreements entered into in connection
with Permitted PharmaBio Investments, so long as such obligations are expected
to be treated as expenses (and not capitalized) on the income statement of such
Person) and (ii) include unearned income to the extent it relates solely to the
receipt of cash in the ordinary course of business in respect of revenues that
have not been recognized on such Person's income statement.

                  "Indemnitee" has the meaning assigned to such term in Section
10.05(b).

                  "Independent Financial Advisor" means an accounting, appraisal
or investment banking firm of national standing or as otherwise approved by the
Administrative Agent or any third party appraiser with experience in appraising
the terms and conditions of the type of transaction or series of related
transactions for which an opinion is required, provided that such firm or
appraiser is not an Affiliate of the Borrower.

                  "Information Memorandum" means (i) the Confidential
Information Memorandum dated as of June 2003 and posted electronically on
Intralinks (and all related updates) relating to the Borrower and this Agreement
and (ii) the Offering Memorandum of the Borrower dated September 12, 2003
related to the Subordinated Notes.

                                      -20-

<PAGE>

                  "Initial Management Payment" has the meaning assigned to such
term in Section 6.07(iv)(a).

                  "Installment Payment Date" has the meaning assigned to such
term in Section 2.06(d).

                  "Interest Expense Coverage Ratio" means, for any Test Period,
the ratio of (a) Consolidated EBITDA to (b) Net Cash Interest Expense, in each
case for such Test Period. For Test Periods ending prior to the one year
anniversary of the Effective Date, Net Cash Interest Expense shall be determined
on a pro forma basis to give effect to the Transactions as if they occurred on
the first day of such Test Period.

                  "Interest Payment Date" means, with respect to any Loan, the
last day of the Interest Period applicable to the Borrowing of which such Loan
is a part and, in the case of a Eurocurrency Borrowing with an Interest Period
of more than three months' duration, (a) each day that would have been an
Interest Payment Date had successive Interest Periods of three months' duration
been applicable to such Borrowing and, in addition, (b) the date of any
refinancing of such Borrowing with a Borrowing of a different Type.

                  "Interest Period" means (a) as to any Eurocurrency Borrowing,
the period commencing on the date of such Borrowing (including any date on which
such Borrowing shall have been converted from a Borrowing of a different Type)
or on the last day of the immediately preceding Interest Period applicable to
such Borrowing, as the case may be, and ending on the numerically corresponding
day (or, if there is no numerically corresponding day, on the last day) in the
calendar month that is 1, 2, 3 or 6 months (or if available to all Lenders, 9 or
12 months) thereafter, as the Borrower may elect; provided that prior to the
31st day after the Effective Date, the Borrower shall only be permitted to
request Interest Periods of seven days, or (b) as to any ABR Borrowing (other
than a Swingline Borrowing), the period commencing on the date of such Borrowing
(including any date on which such Borrowing shall have been converted from a
Borrowing of a different Type) or on the last day of the immediately preceding
Interest Period applicable to such Borrowing, as the case may be, and ending on
the earliest of (i) the next succeeding March 31, June 30, September 30 or
December 31, (ii) the Revolving Credit Maturity Date and (iii) the date such
Borrowing is prepaid in accordance with Section 2.06 or converted in accordance
with Section 2.03 and (c) as to any Swingline Loan, a period commencing on the
date of such Loan and ending on the earliest of (i) the fifth Business Day
thereafter, (ii) the Revolving Credit Maturity Date and (iii) the date such Loan
is prepaid in accordance with Section 2.06; provided, however, that if any
Interest Period would end on a day other than a Business Day, such Interest
Period shall be extended to the next succeeding Business Day unless, in the case
of a Eurocurrency Borrowing only, such next succeeding Business Day would fall
in the next calendar month, in which case such Interest Period shall end on the
next preceding Business Day. Interest shall accrue from and including the first
day of an Interest Period to but excluding the last day of such Interest Period.

                  "Intermediate Parent" has the meaning assigned to such term in
the preamble hereto.

                                      -21-

<PAGE>

                  "Investment" has the meaning assigned to such term in Section
6.04.

                  "Investor Stockholder" shall mean OEP, TPG and Temasek.

                  "Issuing Bank" means an affiliate of Citicorp North America,
Inc., in its capacity as the issuer of Letters of Credit hereunder, and its
successors in such capacity as provided in Section 2.07(i), and any other
Revolving Lender approved by the Administrative Agent and the Borrower. The
Issuing Bank may, in its discretion, arrange for one or more Letters of Credit
to be issued by Affiliates of the Issuing Bank, in which case the term "Issuing
Bank" shall include any such Affiliate with respect to Letters of Credit issued
by such Affiliate.

                  "LC Disbursement" means a payment made by the Issuing Bank
pursuant to a Letter of Credit.

                  "LC Exposure" means, at any time, the sum of (a) the aggregate
undrawn amount of all outstanding Letters of Credit at such time plus (b) the
aggregate amount of all LC Disbursements that have not yet been reimbursed by or
on behalf of the Borrower at such time. The LC Exposure of any Revolving Lender
at any time shall be its Commitment Percentage of the total LC Exposure at such
time.

                  "LC Fees" has the meaning assigned to such term in Section
2.11(b).

                  "Lead Arranger" has the meaning assigned to such term in the
preamble hereto.

                  "Lender Affiliate" means (a) with respect to any Lender, (i)
an Affiliate of such Lender or (ii) any entity (whether a corporation,
partnership, trust or otherwise) that is engaged in making, purchasing, holding
or otherwise investing in bank loans and similar extensions of credit in the
ordinary course of its business and is administered or managed by a Lender or an
Affiliate of such Lender and (b) with respect to any Lender that is a fund which
invests in bank loans and similar extensions of credit and is managed or
administered by a Lender, an Affiliate of a Lender or by the same investment
advisor as a Lender or by an Affiliate of such investment advisor, any other
fund that invests in bank loans and similar extensions and is managed or
administered by a Lender, and Affiliate of a Lender or by the same investment
advisor as a Lender or by an Affiliate of such investment advisor.

                  "Lenders" has the meaning assigned to such term in the
preamble hereto.

                  "Letter of Credit" means any letter of credit issued pursuant
to this Agreement.

                  "LIBO Rate" means, with respect to any Eurocurrency Borrowing
for any Interest Period, (a) in the case of a Borrowing of Dollars, the rate
appearing on Page 3750 of the Telerate Service and (b) in the case of a
Borrowing of Pounds Sterling or Euros, the British Bankers Association Interest
Settlement Rate appearing on the appropriate page of the Telerate Service (or on
any successor or substitute page of such Service, or any successor to or
substitute for such Service, providing rate quotations comparable to those
currently provided on such page of such Service, as determined by the
Administrative Agent from time to time for purposes of providing

                                      -22-

<PAGE>

quotations of interest rates applicable to dollar deposits in the London
interbank market) in the currency of such Borrowing at approximately 11:00 a.m.,
London time, two Business Days prior to the commencement of such Interest
Period, as the rate for Dollar, Euro or Pound Sterling deposits with a maturity
comparable to such Interest Period. In the event that such rate is not available
at such time for any reason, then the "LIBO Rate" with respect to such
Eurocurrency Borrowing for such Interest Period shall be the rate at which
Dollar, Pound Sterling or Euro, as applicable, deposits for a maturity
comparable to such Interest Period are offered by the principal London office of
the Administrative Agent in immediately available funds in the London interbank
market at approximately 11:00 a.m., London time, as of the day two Business Days
prior to the commencement of such Interest Period.

                  "Lien" means, with respect to any asset, (a) any mortgage,
deed of trust, deed to secure debt, lien, pledge, encumbrance, charge,
assignment, hypothecation or security interest in or on such asset or any filing
of any financing statement under the UCC as in effect in the applicable state or
jurisdiction or any other similar notice or lien under any similar notice or
recording statute of any Governmental Authority, in each of the foregoing cases
whether voluntary or imposed by law, (b) the interest of a vendor or a lessor
under any conditional sale agreement, capital lease or title retention agreement
relating to such asset, (c) in the case of securities, any purchase option, call
or similar right of a third party with respect to such securities, (d) in the
case of any investment property or deposit account, any contract or other
agreement, express or implied, under which any Person has the right to control
such investment property or deposit account and (e) any other agreement intended
to create any of the foregoing.

                  "Loan Documents" means this Agreement, the Fee Letter (for
purposes of Section 7.01(a) only), the Collateral Sharing Agreement, the
Guarantee Agreement, the Security Documents and, if requested by a Lender
pursuant to Section 2.08(e), each Note.

                  "Loan Parties" means the Borrower, the Parent Guarantors and
the Subsidiary Loan Parties.

                  "Loan Party Information" has the meaning assigned to such term
in Section 10.16(b).

                  "Loans" means the Revolving Loans, the Swingline Loans, the
Foreign Currency Loans and the Term B Loans.

                  "Management Agreements" means (i) the Management Agreement
dated as of September 25, 2003 among the Parent, OEP, GF Management Company,
LLC, TPG GenPar III, L.P. and Perseus-Soros Management LLC, as in effect on the
Effective Date, and (ii) the Management Agreement dated as of September 25, 2003
between the Parent and Cassia Fund Management Pte Ltd., in each case as in
effect on the Effective Date.

                  "Material Adverse Effect" means a materially adverse effect on
(a) the business, assets, operations, properties or financial condition
(including, but not limited to, contingent liabilities) of the Loan Parties and
their consolidated Subsidiaries taken as a whole, (b) the ability of the Loan
Parties to perform their obligations under the Loan Documents, (c) the rights of
or

                                      -23-

<PAGE>

benefits available to the Lenders under the Loan Documents or (d) the value of
the Collateral or the validity, enforceability, perfection or priority of the
Liens granted to the Collateral Agent (for its benefit and for the benefit of
the other Secured Parties) on the Collateral pursuant to the Security Documents.

                  "Material Indebtedness" means Indebtedness (other than the
Loans and Letters of Credit), or obligations in respect of one or more Hedging
Agreements, of any one or more of the Parent Guarantors, the Borrower or the
Borrower's Subsidiaries, individually or in an aggregate principal amount
exceeding $15.0 million. For purposes of determining Material Indebtedness, the
"principal amount" of the obligations of either Parent Guarantor, the Borrower
or any Subsidiary in respect of any Hedging Agreement at any time shall be the
maximum aggregate amount (giving effect to any netting agreements) that such
Parent Guarantor, the Borrower or such Subsidiary would be required to pay if
such Hedging Agreement were terminated at such time.

                  "Maximum Foreign Currency Sublimit" means US$25,000,000, as
such amount may be reduced hereunder from time to time.

                  "Maximum Rate" has the meaning assigned to such term in
Section 10.09.

                  "Merger" means the merger of Acquisition Corp. with and into
the Borrower pursuant to the terms of the Merger Agreement, with the Borrower
surviving.

                  "Merger Agreement" means the merger agreement dated as of
April 10, 2003 by and among the Borrower, the Parent and Acquisition Corp. and
as amended as of August 18, 2003, as in effect on the Effective Date.

                  "Merger Documents" means the Merger Agreement and all related
schedules, material documents and attachments.

                  "Moody's" means Moody's Investors Service, Inc.

                  "Mortgage" means a mortgage, deed of trust, assignment of
leases and rents, leasehold mortgage or other security document granting a Lien
on any Mortgaged Property to secure the Obligations, including any amendment
thereto. Each Mortgage shall be substantially in the form of Exhibit N or
otherwise satisfactory in form and substance to the Collateral Agent.

                  "Mortgaged Property" means, initially, each parcel of Real
Property identified on Schedule 4.01(y)(A), and each other parcel of Real
Property with respect to which a Mortgage is granted pursuant to Section 5.11.

                  "Multiemployer Plan" means a multiemployer plan within the
meaning of Section 4001(a)(3) of ERISA (i) to which any Loan Party or ERISA
Affiliate is then making or accruing an obligation to make contributions, (ii)
to which any Loan Party or ERISA Affiliate has within the preceding six plan
years made contributions, including any Person which ceased to be

                                      -24-

<PAGE>

an ERISA Affiliate during such six year period, or (iii) with respect to which
Loan Party or any Subsidiary could incur liability.

                  "Net Cash Interest Expense" means, for any period,
Consolidated Interest Expense for such period, less (A) the sum of, to the
extent included in Consolidated Interest Expense, (1) interest expense actually
"paid in kind" in that period, (2) the amortization of any financing fees paid
by, or on behalf of, the Borrower or any of its Restricted Subsidiaries, and (3)
the amortization of debt discounts or capitalization of interest not otherwise
paid in cash, if any, and (B) cash interest income actually received in that
period. For purposes of determining Net Cash Interest Expense for any Test
Period that includes or is after the date that cash interest becomes payable
under the Permitted Discount Notes, Consolidated Interest Expense shall be
determined on a consolidated basis for the Intermediate Parent, the Borrower and
the Restricted Subsidiaries after such date.

                  "Net Cymbalta(TM) Expenses" means, to the extent reducing
Consolidated EBITDA during any Fiscal Quarter, all cash amounts expended by the
Borrower or its Restricted Subsidiaries during the Cymbalta(TM) Ramp Up Period
relating to the Cymbalta(TM) Launch by the Borrower, net of all royalties
relating to Cymbalta(TM) received by the Borrower or its Restricted Subsidiaries
during such Fiscal Quarter.

                  "Net Proceeds" means, with respect to any Equity Issuance,
Debt Incurrence, Asset Sale, Destruction or Taking, the cash proceeds actually
received in respect of such event, including (i) any cash received in respect of
any non-cash proceeds, but only as and when received, (ii) in the case of a
Destruction, insurance proceeds in excess of $5.0 million, and (iii) in the case
of a Taking, condemnation awards and similar payments in excess of $5.0 million,
net of the sum of (i) all reasonable fees and out-of-pocket expenses paid by the
Borrower and its Subsidiaries to third parties in connection with such event,
(ii) the amount of all taxes paid (or reasonably estimated to be payable) by the
Parent Guarantors, the Borrower and the Restricted Subsidiaries, and (iii) in
the case of an Asset Sale, the amount of all payments required to be made by the
Parent Guarantors, the Borrower and the Restricted Subsidiaries as a result of
such event to repay Indebtedness (other than Loans) secured by a Prior Lien (as
defined in the Security Agreement or applicable Mortgage) on such asset and the
amount of any reserves established by the Parent Guarantors, the Borrower and
the Restricted Subsidiaries to fund contingent liabilities reasonably estimated
to be payable, in each case during the year that such event occurred or the next
succeeding two years, and that are directly attributable to such event (as
determined reasonably and in good faith by the Borrower); provided that any
amount by which such reserves are reduced for reasons other than payment of any
such contingent liabilities shall be considered "Net Proceeds" upon such
reduction.

                  "New Investment Subsidiary" has the meaning assigned thereto
in Section 5.19.

                  "Non-Consenting Lender" has the meaning assigned thereto in
Section 2.21.

                  "Non-Operating Investment" means any loans, warrants, equity
securities or other Investments that do not, other than through their sale or
any write up or write down of their value prior to their sale, produce any
operating income, other than interest income on loans, to the Bor-

                                      -25-

<PAGE>

rower (whether positive or negative) and are not convertible or exchangeable
into a security or other Investment that produces, other than through their sale
or any write up or write down of their value prior to their sale, any such
operating income to the Borrower.

                  "Non-U.S. Jurisdiction" means each jurisdiction of
organization of a Subsidiary of the Borrower other than the United States (or
any State thereof) or the District of Columbia.

                  "Non-U.S. Pledge Agreements" means one or more pledge
agreements in form and substance reasonably satisfactory to the Collateral Agent
covering 65% of the voting Equity Interests and 100% of non-voting Equity
Interests owned by a Subsidiary Loan Party in the Non-U.S. Subsidiaries listed
in Schedule 4.01(w).

                  "Non-U.S. Subsidiary" means any Restricted Subsidiary of the
Borrower that is or becomes organized under the laws of a jurisdiction other
than the United States of America or any State thereof or the District of
Columbia.

                  "Note" means a note substantially in the form of Exhibit F-1
or F-2.

                  "Obligations" means the unpaid principal of and interest on
(including interest accruing after the maturity of the Loans made to the
Borrower and interest accruing after the filing of any petition in bankruptcy,
or the commencement of any insolvency, reorganization or like proceeding,
relating to the Borrower, whether or not a claim for post-filing or
post-petition interest is allowed in such proceeding) the Loans made to or LC
Disbursements made pursuant to Letters of Credit issued for the account of the
Borrower and all other obligations and liabilities of the Borrower to any Agent,
the Issuing Bank or to any Lender, whether direct or indirect, absolute or
contingent, due or to become due, or now existing or hereafter incurred, which
may arise under, out of, or in connection with, this Agreement or any other
document made, delivered or given in connection herewith, whether on account of
principal, interest, fees, indemnities, costs or expenses (including, without
limitation, all reasonable fees, charges and disbursements of counsel, or
otherwise).

                  "OEP" means One Equity Partners LLC, a limited liability
company organized under the laws of the State of Delaware.

                  "OEP Equity Investment" means gross cash proceeds in an amount
not less than $454,800,000 to purchase equity by OEP, Temasek, TPG and other
Persons in the Parent pursuant to the Subscription Agreements, with such amounts
(net of permitted fees and expenses) to be contributed on the Effective Date as
a common equity contribution to the Intermediate Parent and then to the
Borrower, provided, that in no event shall OEP make an initial cash equity
investment of less than $200,000,000.

                  "OEP Subscription Agreement" means the subscription agreement
dated as of August 28, 2003 between OEP and the Parent.

                  "Organic Document" means (i) relative to each Person that is a
corporation, its charter, its by-laws and all shareholder agreements, voting
trusts and similar arrangements

                                      -26-

<PAGE>

applicable to any of its authorized shares of capital stock, (ii) relative to
each Person that is a partnership, its partnership agreement and any other
similar arrangements applicable to any partnership or other equity interests in
the Person and (iii) relative to any Person that is any other type of legal
entity, such documents as shall be comparable to the foregoing.

                  "Other List" has the meaning provided to such terms in Section
6.19.

                  "Other Taxes" means any and all stamp, documentary or similar
Taxes, or any other excise or property Taxes or similar levies that arise on
account of any payment made or required to be made under any Loan Document or
Note or from the execution, delivery, registration, recording or enforcement of
any Loan Document or Note.

                  "Parent" has the meaning assigned to such term in the preamble
hereto.

                  "Parent Guarantors" means each of the Parent and Intermediate
Parent.

                  "Participant" has the meaning assigned to such term in Section
10.04(f).

                  "PBGC" means the Pension Benefit Guaranty Corporation referred
to and defined in ERISA.

                  "Pension Plan" means a "pension plan," as such term is defined
in Section 3(2) of ERISA, which is subject to Title IV of ERISA (other than a
Multiemployer Plan) and to which any Loan Party or any ERISA Affiliate may have
liability, including any liability by reason of having been a substantial
employer within the meaning of Section 4063 of ERISA at any time during the
preceding five years, or by reason of being deemed to be a contributing sponsor
under Section 4069 of ERISA.

                  "Perfection Certificate" means a certificate in the form of
Annex II to the Security Agreement or any other form approved by the Collateral
Agent.

                  "Permitted Acquisition" means any acquisition, whether by
purchase, merger, consolidation or otherwise, by the Borrower or any Subsidiary
Loan Party of all or substantially all the assets of, or all the Equity
Interests in, a Person or a division, line of business or other business unit of
a Person so long as (a) such acquisition shall not have been preceded by a
tender offer that has not been approved or otherwise recommended by the board of
directors of such Person, (b) such assets are to be used in, or such Person so
acquired is engaged in, as the case may be, a business of the type conducted by
the Borrower and its Restricted Subsidiaries on the Effective Date or in a
business reasonably related thereto (including without limitation any Permitted
PharmaBio Investment), (c) immediately after giving effect thereto, (i) no
Default has occurred and is continuing or would result therefrom, (ii) all
transactions related thereto are consummated in all material respects in
accordance with applicable laws, (iii) all the Equity Interests of each Domestic
Subsidiary formed for the purpose of or resulting from such acquisition shall be
owned directly by the Borrower or a Subsidiary Loan Party and all actions
required to be taken under Sections 5.11, 5.12 and 5.16 shall have been taken,
(iv) the Borrower and its Restricted Subsidiaries are in compliance, on a pro
forma basis after giving effect to such acquisi-

                                      -27-

<PAGE>

tion, with the covenants contained in Sections 6.13 through 6.16 recomputed as
at the date of the last ended Test Period, as if such acquisition (and any
related incurrence or repayment of Indebtedness) had occurred on the first day
of the relevant Test Period (provided that any acquisition that occurs prior to
the first Test Period under such Sections shall be deemed to have occurred after
the end of such first Test Period), (v) any Indebtedness or any Preferred Stock
that is incurred, acquired or assumed in connection with such acquisition shall
be in compliance with Section 6.01, (vi) after giving effect to such acquisition
and any Revolving Credit Borrowings made in connection therewith, the sum of (A)
the Total Revolving Credit Commitment less the Revolving Credit Exposure of all
Revolving Lenders, plus (B) cash and/or Permitted Investments on the latest
balance sheet of the Borrower that has been delivered to Lenders pursuant to
Section 5.01(a) or (b) (with such Permitted Investments valued at the amount set
forth on such balance sheet), shall not be less than $75.0 million and (vii) the
Borrower has delivered to the Administrative Agent an officers' certificate to
the effect set forth in clauses (a), (b) and (c)(i) through (vi) above, together
with all relevant financial information for the Person or assets to be acquired.

                  "Permitted Discount Notes" means senior discount notes issued
by the Intermediate Parent, (a) the terms of which notes (i) do not provide for
any scheduled repayment, mandatory redemption or sinking fund obligation or
redemption or repurchase at the option of the holder thereof prior to the final
maturity date of the Subordinated Notes (other than in connection with the
occurrence of a "change of control" or "asset sale" upon substantially the same
terms set forth in the Subordinated Notes), (ii) do not provide for any cash
interest payments prior to the earlier of (A) the date that is the five year
anniversary of the date of issuance of such Permitted Discount Notes and (B) the
date that is the seven year anniversary of the Effective Date and (iii) do not
have the benefit of Guarantees or any other credit support from the Borrower and
its Subsidiaries and (b) the covenants, events of default and other terms of
which (other than interest rate and redemption premiums), taken as a whole, are
not more restrictive to the Borrower and its Subsidiaries than those in the
Subordinated Notes (as reasonably determined by the Administrative Agent) (it
being understood that changes to the covenants and events of default that are
necessary for an issuance of notes by a holding company shall not be deemed more
restrictive).

                  "Permitted Holders" means each of OEP, Dr. Dennis B. Gillings,
the Gillings Family Limited Partnership, the GFEF Limited Partnership, GF
Management Company, LLC, the Gillings Family Foundation, Temasek and TPG and
each of their respective Affiliates and Permitted Transferees.

                  "Permitted Investments" means:

                  (a)      marketable direct obligations issued by, or
         unconditionally guaranteed by, the United States Government or any
         member state of the European Union (as it exists on the Effective Date)
         or issued by any agency or instrumentality thereof and backed by the
         full faith and credit of the United States of America or such member
         state of the European Union, in each case maturing within one year from
         the date of acquisition thereof;

                  (b)      marketable direct obligations issued by any State of
         the United States of America or any political subdivision of any such
         State or any public instrumentality

                                      -28-

<PAGE>

         thereof maturing within one year from the date of acquisition thereof
         and, at the time of acquisition, having one of the two highest ratings
         obtainable from either S&P or Moody's;

                  (c)      commercial paper maturing no more than one year from
         the date of creation thereof and, at the time of acquisition, having a
         rating of at least A-1 from S&P or at least P-1 from Moody's;

                  (d)      time deposits, demand deposits, certificates of
         deposit, Eurodollar time deposits or bankers' acceptances maturing
         within one year from the date of acquisition thereof or overnight bank
         deposits, in each case, issued by any bank organized under the laws of
         any member state of the European Union (as it exists on the Effective
         Date), the United States of America or any State thereof or the
         District of Columbia or any U.S. branch of a foreign bank having at the
         date of acquisition thereof combined capital and surplus of not less
         than $500.0 million;

                  (e)      repurchase obligations with a term of not more than
         90 days for underlying securities of the types described in clause (a)
         above entered into with any bank meeting the qualifications specified
         in clause (d) above; and

                  (f)      investments in money market funds which invest
         substantially all their assets in securities of the types described in
         clauses (a) through (e) above.

                  "Permitted Lien" has the meaning assigned to such term in
Section 6.02.

                  "Permitted PharmaBio Investments" means Investments by the
Borrower or any Subsidiary Loan Party in any Person (other than a Subsidiary
with the exception of Bioglan) that is involved in the development and
production of pharmaceutical products, or in other lines of business within the
pharmaceutical services or biotechnology industry or related or complementary
businesses in the healthcare industry including consumer marketing and
information technology, pharmaco-economics consulting and pharmaco-genomics,
that exist as of the Effective Date (as identified on Schedule 6.04) or
permitted to be made after the Effective Date pursuant to Section 6.04(x) or
(xi).

                  "Permitted PharmaBio Swaps" means the exchange by the Borrower
or any Subsidiary Loan Party of a Permitted PharmaBio Investment with a Person
that is not an Affiliate of the Borrower for an Investment of equal fair value
as determined by the board of directors of the Borrower in good faith that would
constitute a Permitted PharmaBio Investment; provided that, with respect to any
transaction or series of related transactions that constitute a Permitted
PharmaBio Swap with an aggregate fair value in excess of $50.0 million, the
Borrower, prior to consummation thereof, shall be required to obtain written
opinion from an Independent Financial Advisor to the effect that such
transaction or series or related transactions are fair, from a financial point
of view, to the Borrower or such Subsidiary Loan Party, taken as a whole. For
the avoidance of doubt, if with respect to any disposition of any Permitted
PharmaBio Investment the consideration received therefor includes both cash and
another Permitted PharmaBio Investment, then for the purposes of determining
compliance with Section 6.05, such transaction shall

                                      -29-

<PAGE>

be analyzed as a Permitted PharmaBio Swap to the extent of the fair value of
such other Permitted PharmaBio Investment received in exchange therefor pursuant
to Section 6.05(v)(B) and a separate sale of the remaining portion of such
Permitted PharmaBio Investment for cash which must comply with Section
6.05(v)(A); provided that the amount of cash and the fair value of such other
Permitted PharmaBio Investment so received shall be at least equal to the fair
value of the Permitted PharmaBio Investment so disposed of.

                  "Permitted Subordinated Indebtedness" means (a) additional
Subordinated Notes issued after the Effective Date under the Subordinated Notes
Indenture and (b) other subordinated notes issued by the Borrower, (i) the terms
of which notes (A) do not provide for any scheduled repayment, mandatory
redemption or sinking fund obligation prior to the final maturity date of the
Subordinated Notes or (B) provide for subordination to the Obligations under the
Loan Documents to substantially the same extent as the Subordinated Notes
Indenture, (ii) the covenants, events of default, Subsidiary guaranties and
other terms of which (other than interest rate and redemption premiums), taken
as a whole, are not more restrictive to the Borrower and its Subsidiaries than
those in the Subordinated Notes (as reasonably determined by the Administrative
Agent) and (iii) no Subsidiary of the Borrower or the Parent Guarantors is an
obligor under such notes that is not an obligor under the Subordinated Notes.

                  "Permitted Transferee" means (i) with respect to any Permitted
Holder who is a natural person, (A) such Person's estate, spouse, heir,
ancestors, lineal descendants (including by adoption and step children, and the
lineal descendants thereof), legatees, legal representatives or trustee of a
bona fide trust of which one or more of the foregoing or such Permitted Holder
is or are the controlling trustees, principal beneficiaries or grantors thereof,
whether through the ownership of voting securities, by contract or otherwise,
and (B) any entity controlled, directly or indirectly, by any Persons referred
to in the preceding clause (A) and (ii) with respect to any Investor
Stockholders, (A) any other Investor Stockholder or any of their Permitted
Transferees, (B) any director, officer, or general partner, limited partner,
manager, member or Affiliate of any Investor Stockholder or any of their
Permitted Transferees, or (C) any director, officer, general partner or limited
partner of any Affiliate of any Investor Stockholder or any of their Permitted
Transferees.

                  "Person" means any natural person, corporation, trust, joint
venture, association, company, partnership, limited liability company or
government, or any agency or political subdivision thereof.

                  "Plan" means any Pension Plan or Welfare Plan.

                  "Platform" has the meaning assigned to such term in Section
10.17(b).

                  "Pledge Agreement" means the Pledge Agreement, substantially
in the form of Exhibit I, among the Loan Parties and the Collateral Agent for
the benefit of the Secured Parties.

                  "Pledged Securities" has the meaning provided in the Pledge
Agreement.

                  "Pound Sterling" or "(pound)" means the lawful currency of the
United Kingdom.

                                      -30-

<PAGE>

                  "Preferred Stock" means, with respect to any Person, any and
all preferred or preference Equity Interests (however designated) of such Person
whether or not outstanding or issued on the Effective Date.

                  "Prepayment Date" has the meaning assigned to such term in
Section 2.06(f).

                  "Pro Rata Percentage" of any Revolving Lender at any time
means the percentage of the aggregate Available Revolving Credit Commitment
represented by such Lender's Available Revolving Credit Commitment.

                  "Projected Financial Statements" has the meaning assigned to
such term in Section 3.18(c).

                  "Property" means any right, title or interest in or to
property or assets of any kind whatsoever, whether real, personal or mixed and
whether tangible or intangible and including any ownership interests of any
Person.

                  "Public Equity Offering" means an underwritten public offering
of Equity Interests of the Parent after the Effective Date, pursuant to an
effective registration statement filed under the Securities Act.

                  "Real Property" means all right, title and interest of any
Loan Party or any of its respective Domestic Subsidiaries in and to a parcel of
real property owned, leased or operated (including, without limitation, any
leasehold estate) by any Loan Party or any of its respective Domestic
Subsidiaries together with, in each case, all improvements and appurtenant
fixtures, equipment, personal property, easements and other property and rights
incidental to the ownership, lease or operation thereof.

                  "Register" shall have the meaning given such term in Section
10.04(d).

                  "Regulation U" means Regulation U of the Board as from time to
time in effect and all official rulings and interpretations thereunder or
thereof.

                  "Regulation X" means Regulation X of the Board as from time to
time in effect and all official rulings and interpretations thereunder or
thereof.

                  "Related Parties" means, with respect to any specified Person,
such Person's Affiliates and the respective directors, officers, employees,
agents, trutees and advisors of such Person and such Person's Affiliates.

                  "Release" means any spilling, leaking, pumping, pouring,
emitting, emptying, discharging, injecting, escaping, leaching, dumping,
disposing, depositing, dispersing, emanating or migrating of any Hazardous
Material in, into, onto or through the Environment.

                  "Remedial Action" means (a) "remedial action" as such term is
defined in CERCLA, 42 U.S.C. Section 9601(24), and (b) all other actions
required by any Governmental Au-

                                      -31-

<PAGE>

thority or voluntarily undertaken to: (i) clean up, remove, treat, abate or
otherwise take corrective action to address any Hazardous Material in the
Environment; (ii) prevent the Release or threat of Release, or minimize the
further Release of any Hazardous Material so it does not migrate or endanger or
threaten to endanger public health, welfare or the Environment; or (iii) perform
studies and investigations in connection with, or as a precondition to, (i) or
(ii) above.

                  "Requirement of Law" means, as to any Person, any law, treaty,
rule or regulation or determination of an arbitrator or a court or other
Governmental Authority, in each case applicable to or binding upon such Person
or any of its property or assets or to which such Person or any of its property
or assets is subject.

                  "Requisite Foreign Currency Lenders" means, collectively,
Foreign Currency Lenders having more than fifty percent (50%) of (i) the
aggregate outstanding amount of the Foreign Currency Sublimits or (ii) after the
Revolving Credit Maturity Date, the Dollar Equivalent of the Foreign Currency
Loans.

                  "Requisite Lenders" means, at any time, Lenders having more
than fifty percent (50%) of the sum of (a) the aggregate amount of the Revolving
Credit Commitments or, after the Revolving Credit Maturity Date, the Revolving
Credit Exposure and (b) the aggregate outstanding amount of all Term B Loans;
provided, that if at any time any Revolving Lender (together with its
Affiliates) holds more than 50% of the aggregate Revolving Credit Commitments or
Revolving Credit Exposure, as applicable, the "Requisite Lenders" shall require
holders of 66.3% of the aggregate Revolving Credit Commitments or, after the
Revolving Credit Maturity Date, the Revolving Credit Exposure.

                  "Requisite Revolving Lenders" means, collectively, Lenders
having more than fifty percent (50%) of the aggregate outstanding amount of the
Revolving Credit Commitments or, after the Revolving Credit Maturity Date, the
Revolving Credit Exposure.

                  "Reset Date" has the meaning assigned to such term in Section
1.04(a).

                  "Responsible Officer" of any corporation, partnership or other
entity means any executive officer or Financial Officer of such corporation,
partnership or other entity and any other officer or similar official thereof
responsible for the administration of the obligations of such corporation,
partnership or other entity in respect of this Agreement.

                  "Restricted Payment" means any direct or indirect dividend or
other distribution (whether in cash, securities or other property) with respect
to any Equity Interests or Equity Rights in either Parent Guarantor, the
Borrower or any Restricted Subsidiary, or any payment (whether in cash,
securities or other property), including any sinking fund or similar deposit, on
account of the purchase, redemption, retirement, acquisition, cancellation or
termination of any Equity Interests or Equity Rights in either Parent Guarantor,
the Borrower or any Restricted Subsidiary. The granting of security by any
Restricted Subsidiary pursuant to the terms of this Agreement shall not be
considered a Restricted Payment.

                                      -32-

<PAGE>

                  "Restricted Subsidiary" means each Subsidiary of the Borrower
that is not an Unrestricted Subsidiary.

                  "Revolving Credit Borrowing" means a Borrowing comprised of
Revolving Dollar Loans.

                  "Revolving Credit Borrowing Request" means a Borrowing Request
in connection with a Revolving Credit Borrowing.

                  "Revolving Credit Commitment" means, with respect to each
Revolving Lender, the commitment of such Revolving Lender to make Revolving
Loans and to acquire participations in Letters of Credit, Swingline Loans and
Foreign Currency Loans hereunder, expressed in each case as an amount
representing the maximum principal amount of such Revolving Lender's Revolving
Credit Exposure hereunder, as the same may be reduced from time to time pursuant
to the provisions of this Agreement. The initial amount of each Revolving
Lender's Revolving Credit Commitment is set forth on Schedule 2.01 (in the case
of Revolving Credit Commitments in effect on the Effective Date) or in the
Assignment and Acceptance pursuant to which such Lender shall have assumed its
Revolving Credit Commitment, as applicable. The aggregate amount of the
Revolving Lenders' Revolving Credit Commitments as of the Effective Date is
$75.0 million.

                  "Revolving Credit Commitment Period" means the period from and
including the Effective Date to but not including the Revolving Credit Maturity
Date or any earlier date on which the Revolving Credit Commitments to make
Revolving Loans pursuant to Section 2.01 shall terminate as provided herein.

                  "Revolving Credit Exposure" means with respect to any
Revolving Lender at any time, the sum of (a) the aggregate principal amount at
such time of all outstanding Revolving Dollar Loans of such Revolving Lender,
plus (b) such Revolving Lender's LC Exposure at such time, plus (c) such
Revolving Lender's Commitment Percentage of the aggregate principal amount at
such time of all outstanding Swingline Loans, plus (d) such Revolving Lender's
Foreign Currency Exposure at such time.

                  "Revolving Credit Maturity Date" means September 25, 2008, the
fifth anniversary of the Effective Date.

                  "Revolving Dollar Lender" means each Revolving Lender other
than the Foreign Currency Lender.

                  "Revolving Dollar Loans" means the revolving loans made by the
Revolving Lenders in Dollars to the Borrower pursuant to clause (ii) of Section
2.01(a). Each Revolving Dollar Loan shall be a Eurocurrency Revolving Loan or an
ABR Revolving Loan.

                  "Revolving Lender" means a Lender with a commitment to make
Revolving Loans or with any Revolving Credit Exposure, in its capacity as such.

                                      -33-

<PAGE>

                  "Revolving Loans" means Foreign Currency Loans and Revolving
Dollar Loans.

                  "S&P" means Standard & Poor's, a division of The McGraw-Hill
Companies.

                  "SDN List" has the meaning provided to such term in Section
6.19

                  "SEC" means the Securities and Exchange Commission.

                  "Secured Parties" has the meaning assigned to such term in the
Security Agreement.

                  "Security Agreement" means the Security Agreement,
substantially in the form of Exhibit J, among the Loan Parties and the
Collateral Agent for the benefit of the Secured Parties.

                  "Security Documents" means the Security Agreement, the Pledge
Agreement, the Non-U.S. Pledge Agreements, the Mortgages, the Perfection
Certificate, Cash Management Agreements (as defined in the Security Agreement)
and Hedging Agreements executed by the Loan Parties and the Collateral Agent and
each other security agreement or other instrument or document executed and
delivered pursuant to Section 5.11, 5.12 or 5.16 to secure any of the
Obligations.

                  "Senior Indebtedness" of the Borrower means, without
duplication:

                  (a)      all Consolidated Indebtedness under this Agreement or
         any Loan Documents whether outstanding on the Effective Date or
         thereafter incurred; and

                  (b)      any other Consolidated Indebtedness permitted to be
         incurred under Section 6.01, whether outstanding on the Effective Date
         or thereafter incurred, except the Subordinated Notes and any Permitted
         Subordinated Indebtedness.

                  "Senior Leverage Ratio" means, for any Test Period, the ratio
of (a) Senior Indebtedness as of such date to (b) Consolidated EBITDA for such
Test Period. For purposes of calculating the Senior Leverage Ratio, Consolidated
EBITDA shall be calculated on a pro forma basis in accordance with Regulation
S-X under the Exchange Act to give effect to any Permitted Acquisition
consummated during the applicable Test Period as if such Permitted Acquisition
were consummated on the first day of such Test Period.

                  "Series A Preferred Stock" means the preferred stock of the
Parent designated in the Parent's Amended and Restated Certificate of
Incorporation filed on September 24, 2003, as "Series A Redeemable Preferred
Stock."

                  "Statutory Reserve Rate" means a fraction (expressed as a
decimal) the numerator of which is the number one and the denominator of which
is the number one minus the aggregate (expressed as a decimal) of the maximum
reserve percentages (including any marginal, special, emergency or supplemental
reserves) expressed as a decimal established by any Governmental Authority of
the United States or of the jurisdiction of such currency or any jurisdiction in
which

                                      -34-

<PAGE>

Loans in such currency are made to which banks in such jurisdiction are subject
for any category of deposits or liabilities customarily used to fund loans in
such currency or by reference to which interest rates applicable to Loans in
such currency are determined. Such reserve percentages shall include those
imposed pursuant to Regulation D of the Board. Eurocurrency Loans shall be
deemed to constitute eurocurrency funding and to be subject to such reserve
requirements without benefit of or credit for proration, exemptions or offsets
that may be available from time to time to any Lender under such Regulation D or
any other applicable law, rule or regulation and without regard to whether any
Lender actually obtains or maintains eurocurrency funding for its Eurocurrency
Loans. The Statutory Reserve Rate shall be adjusted automatically on and as of
the effective date of any change in any reserve percentage.

                  "Subordinated Notes" means $450,000,000 aggregate principal
amount of 10.0% Senior Subordinated Notes due 2013 of the Borrower issued on the
Effective Date.

                  "Subordinated Notes Documents" shall mean the Subordinated
Notes, the Subordinated Notes Indenture and all other material documents
executed and delivered with respect to the Subordinated Notes or the
Subordinated Notes Indenture, as in effect on the Effective Date and as the same
may be modified, supplemented, restated and/or amended from time to time in
accordance with the terms hereof and thereof.

                  "Subordinated Notes Indenture" shall mean the Indenture, dated
as of September 25, 2003, between the Borrower, the Subsidiary Loan Parties and
Wells Fargo Bank Minnesota N.A., as Trustee, as in effect on the Effective Date
and as the same may be modified, supplemented and/or amended from time to time
in accordance with the terms hereof and thereof.

                  "Subordination Provisions" has the meaning assigned to such
term in Section 7.01(l).

                  "Subscription Agreements" means the OEP Subscription
Agreement, the TPG Subscription Agreement, the Temasek Subscription Agreement
and similar agreements with other Persons making cash equity investments, as
contemplated by the definition of "OEP Equity Investment."

                  "Subsidiary" means, with respect to any Person, (i) any
corporation of which more than 50% of the outstanding capital stock having
ordinary voting power to elect a majority of the board of directors of such
corporation (irrespective of whether at the time capital stock of any other
class or classes of such corporation shall or might have voting power upon the
occurrence of any contingency) is at the time directly or indirectly owned by
such Person, by such Person and one or more other Subsidiaries of such Person,
or by one or more other Subsidiaries of such Person; (ii) any partnership of
which more than 50% of the outstanding partnership interests having the power to
act as a general partner of such partnership (irrespective of whether at the
time any partnership interests other than general partnership interests of such
partnership shall or might have voting power upon the occurrence of any
contingency) are at the time directly or indirectly owned by such Person, by
such Person and one or more other Subsidiaries of such Person, or by one or more
other Subsidiaries of such Person; or (iii) any other legal entity the accounts
of which would or should be consolidated with those of such Person on a
consoli-

                                      -35-

<PAGE>

dated balance sheet of such Person prepared in accordance with GAAP. Unless
otherwise indicated, when used in this Agreement, the term "Subsidiary" shall
refer to a Subsidiary of the Borrower.

                  "Subsidiary Loan Party" means each of the Borrower's Domestic
Subsidiaries that guarantee the Obligations pursuant to the Guarantee Agreement,
as identified on Schedule 6.04.

                  "Survey" means a survey of any Mortgaged Property (and all
improvements thereon): (i) prepared by a surveyor or engineer licensed to
perform surveys in the state where such Mortgaged Property is located, (ii)
dated (or redated) not earlier than six months prior to the date of delivery
thereof unless there shall have occurred within six months prior to such date of
delivery any exterior construction (i.e., outside of the perimeter and height of
improvements shown on such survey) on the site of such Mortgaged Property, in
which event such survey shall be dated (or redated) after the completion of such
construction or if such construction shall not have been completed as of such
date of delivery, not earlier than 20 days prior to such date of delivery, (iii)
certified by the surveyor (in a manner reasonably acceptable to the Collateral
Agent) to the Collateral Agent and the Title Company, (iv) complying in all
respects with the minimum detail requirements of the American Land Title
Association as such requirements are in effect on the date of preparation of
such survey and (v) sufficient for the Title Company to remove all standard
survey exceptions from the title insurance policy (or commitment) and issue a
survey endorsement.

                  "Swingline Commitment" means the commitment of the Swingline
Lender to make Loans pursuant to Section 2.05.

                  "Swingline Exposure" means, at any time, the aggregate
principal amount of all Swingline Loans outstanding at such time. The Swingline
Exposure of any Revolving Lender at any time shall be its Commitment Percentage
of the total Swingline Exposure at such time.

                  "Swingline Lender" means Citicorp North America, Inc., in its
capacity as lender of Swingline Loans.

                  "Swingline Loan" has the meaning assigned to such term in
Section 2.05(a).

                  "Syndication Agents" has the meaning assigned to such term in
the preamble hereto.

                  "Taking" means any taking of any Property of either of the
Parent Guarantors, the Borrower or any Restricted Subsidiary or any portion
thereof, in or by condemnation or other eminent domain proceedings pursuant to
any law, general or special, or by reason of the temporary requisition or use of
any Property of either of the Parent Guarantors, the Borrower or any Restricted
Subsidiary or any portion thereof, by any Governmental Authority.

                  "Taxes" has the meaning assigned to such term in Section
2.17(a).

                                      -36-

<PAGE>

                  "Temasek" means Temasek Life Science Investments Private
Limited, a Singapore Corporation.

                  "Temasek Subscription Agreement" means the subscription
agreement dated as of August 28, 2003 between Temasek and the Parent.

                  "Term B Borrowing" means a Borrowing comprised of Term B Loans
on the Effective Date.

                  "Term B Borrowing Request" means a Borrowing Request in
connection with a Term B Borrowing made on the Effective Date.

                  "Term B Commitment" means, with respect to each Lender, the
commitment, if any, of such Lender to make a Term B Loan hereunder on the
Effective Date, expressed as an amount representing the maximum principal amount
of the Term B Loan to be made by such Lender hereunder, as the same may be
reduced from time to time pursuant to the provisions of this Agreement. The
initial amount of each Lender's Term B Commitment is set forth on Schedule 2.01
(in the case of Term B Commitments in effect on the Effective Date) or in the
Assignment and Acceptance pursuant to which such Lender shall have assumed its
Term B Commitment, as applicable. The initial aggregate amount of the Lenders'
Term B Commitments is $310.0 million.

                  "Term B Lender" means a Lender with a Term B Commitment or an
outstanding Term B Loan, in its capacity as such.

                  "Term B Loan Maturity Date" means September 25, 2009, the
sixth anniversary of the Effective Date.

                  "Term B Loans" means the Loans made pursuant to clause (i) of
Section 2.01(a).

                  "Terminated Lender" has the meaning assigned thereto in
Section 2.21.

                  "Test Period" means (i) for the covenants contained in
Sections 6.13 through 6.15, the four consecutive complete Fiscal Quarters of the
Borrower then last ended as of each date listed under Test Period and (ii) for
all other provisions in this Agreement, the four consecutive complete Fiscal
Quarters of the Borrower ended as of the time indicated. Compliance with such
covenants shall be tested, as of the end of each Test Period, on the date on
which the financial statements pursuant to Section 5.01(a) or (b) have been, or
should have been, delivered for the applicable fiscal period.

                  "Title Company" means First American Title Insurance Company,
Chicago Title Insurance Company or such other title insurance or abstract
company as shall be approved by the Collateral Agent.

                  "Total Leverage Ratio" means, for any Test Period, the ratio
of (a) Consolidated Indebtedness as of such date to (b) Consolidated EBITDA for
such Test Period. For purposes of

                                      -37-

<PAGE>

calculating the Total Leverage Ratio, Consolidated EBITDA shall be calculated on
a pro forma basis in accordance with Regulation S-X under the Exchange Act to
give effect to any Permitted Acquisition consummated during the applicable Test
Period as if such Permitted Acquisition were consummated on the first day of
such Test Period.

                  "Total Revolving Credit Commitment" means, at any time, the
aggregate amount of the Revolving Credit Commitments, as in effect at such time.

                  "TPG" means TPG Quintiles Holdco LLC, a limited liability
company organized under the laws of the State of Delaware.

                  "TPG Subscription Agreement" means the subscription agreement
dated as of August 28, 2003 between TPG and the Parent.

                  "Transactions" means the execution and delivery by each Loan
Party of each of the Loan Documents and the Borrowing of the Term B Loans
hereunder, the issuance of the Subordinated Notes, the Equity Investments, the
Merger and the payment of Fees and expenses in connection with the foregoing.

                  "Transferee" has the meaning assigned to such term in Section
2.17(a).

                  "Type" when used in respect of any Loan or Borrowing, refers
to the Rate by reference to which interest on such Loan or on the Loans
comprising such Borrowing is determined. For purposes hereof, "Rate" shall
include the Adjusted LIBO Rate and the Alternate Base Rate.

                  "UCC" shall mean the Uniform Commercial Code as in effect in
the applicable state or jurisdiction.

                  "Unrefunded Swingline Loans" has the meaning assigned thereto
in Section 2.05(c).

                  "Unrestricted Subsidiary" means any Subsidiary of the
Borrower, that, at the time of determination, shall be an Unrestricted
Subsidiary (as designated by the board of directors of the Borrower, as provided
below). The board of directors of the Borrower may designate any Subsidiary of
the Borrower (including any newly acquired or newly formed Subsidiary at or
prior to the time it is so formed or acquired), to be an Unrestricted Subsidiary
if (a) no Default is existing or will occur as a consequence thereof, (b) such
Subsidiary does not own any Capital Stock of, or own or hold any Lien on any
property of, the Borrower or any of its Subsidiaries (other than Unrestricted
Subsidiaries), (c) such Subsidiary and each of its Subsidiaries has not at the
time of designation, and does not thereafter, create, incur, issue, assume,
guarantee, or otherwise become directly or indirectly liable with respect any
Indebtedness pursuant to which the lender has recourse to any property of the
Borrower or any of its Subsidiaries (other than Unrestricted Subsidiaries) and
(d) either (A) at the time of such designation such Subsidiary shall not have
more than de minimis assets or (B) the Borrower shall be permitted to make an
Investment in such Subsidiary in an amount equal to the fair market value of the
Borrower's Equity Interests in such Subsidiary pursuant to Section 6.04(xiii).
Any Subsidiary of an Unrestricted Subsidiary

                                      -38-

<PAGE>

shall be an Unrestricted Subsidiary for purposes of this Agreement. The board of
directors of the Borrower may redesignate an Unrestricted Subsidiary of the
Borrower to be a Restricted Subsidiary if (i) no Default is existing or will
occur as a consequence thereof, (ii) such Subsidiary is a Wholly Owned U.S.
Subsidiary and becomes a party to the Guarantee Agreement, Security Agreement
and the Pledge Agreement, (iii) after giving effect to such redesignation and
the incurrence of any Indebtedness incurred by such Subsidiary since the last
day of the immediately preceding Test Period on a pro forma basis as if it was
incurred on the first day of the immediately preceding Test Period (but tested
as if the applicable ratio were the ratio for the next succeeding Test Period),
the Borrower would be in compliance with Sections 6.13 through 6.16, inclusive,
and (iv) all Indebtedness, Liens and Investments of such Subsidiary outstanding
immediately after such designation would, if incurred at such time, have been
permitted to be incurred (and shall be deemed to have been incurred) for all
purposes of this Agreement. Each such designation shall be evidenced by filing
with the Administrative Agent a certified copy of the resolution giving effect
to such designation and an Officers' Certificate certifying that such
designation complied with the foregoing conditions.

                  "Verispan" means Verispan, L.L.C, a limited liability company
organized under the laws of the State of Delaware.

                  "Welfare Plan" means a "welfare plan," as such term is defined
in Section 3(1) of ERISA, that is maintained or contributed to by a Loan Party
or any Subsidiary or with respect to which a Loan Party or any Subsidiary could
incur liability.

                  "Wholly Owned" means, with respect to a Subsidiary, a
Subsidiary all of the voting stock of which (except directors' qualifying shares
and shares required by applicable law to be held by a Person other than the
Borrower) is at such time owned, directly or indirectly, by the Borrower and its
other Wholly Owned Subsidiaries.

                  "Withdrawal Liability" means liability to a Multiemployer Plan
as a result of a complete or partial withdrawal from such Multiemployer Plan, as
such terms are defined in Part 1 of Subtitle E of Title IV of ERISA.

                  SECTION 1.02. Classification of Loans and Borrowings. For
purposes of this Agreement, Loans may be classified and referred to by Class
(e.g., a "Revolving Loan" or by Type (e.g., a "Eurocurrency Loan") or by Class
and Type (e.g., a "Eurocurrency Revolving Loan"). Borrowings also may be
classified and referred to by Class (e.g., a "Revolving Credit Borrowing") or by
Type (e.g., a "Eurocurrency Borrowing") or by Class and Type (e.g., a
"Eurocurrency Revolving Credit Borrowing").

                  SECTION 1.03. Terms Generally. (a) The definitions in Section
1.01 shall apply equally to both the singular and plural forms of the terms
defined. Whenever the context may require, any pronoun shall include the
corresponding masculine, feminine and neuter forms. The words "include",
"includes" and "including" shall be deemed to be followed by the phrase "without
limitation". All references herein to Articles, Sections, Exhibits and Schedules
shall be deemed references to Articles and Sections of, and Exhibits and
Schedules to, this Agreement unless the context shall otherwise require. Except
as otherwise expressly provided herein, (i) any

                                      -39-

<PAGE>

reference in this Agreement to any Loan Document means such document as amended,
restated, supplemented or otherwise modified from time to time and (ii) all
terms of an accounting or financial nature shall be construed in accordance with
GAAP, as in effect from time to time; provided, however, that for purposes of
determining compliance with the covenants contained in Article VI, all
accounting terms herein shall be interpreted and all accounting determinations
hereunder shall be made in accordance with GAAP as in effect on the Effective
Date and applied on a basis consistent with the application used in the
financial statements referred to in Section 3.07.

                  (b)      If any payment under this Agreement or any other Loan
Document shall be due on any day that is not a Business Day, the date for
payment shall be extended to the next succeeding Business Day, and in the case
of any payment accruing interest, interest thereon shall be paid for the period
of such extension.

                  SECTION 1.04. Exchange Rates. (a) Not later than 1:00 p.m.,
New York City time, on each Calculation Date, the Administrative Agent shall (i)
determine the Exchange Rate as of such Calculation Date with respect to Pounds
Sterling or Euros and (ii) give written notice thereof to the Lenders and the
Borrower. The Exchange Rates so determined shall become effective on the first
Business Day immediately following the relevant Calculation Date (a "Reset
Date") or other date of determination, shall remain effective until the next
succeeding Reset Date, and shall for purposes of this Agreement (other than
Section 2.04, Section 10.19 or any other provision expressly requiring the use
of a current Exchange Rate) be the Exchange Rates employed in converting any
amounts between U.S. Dollars and Pounds Sterling or Euros.

                  (b)      Not later than 5:00 p.m., New York City time, on each
Reset Date and on each date on which Foreign Currency Loans are made, the
Administrative Agent shall (i) determine the aggregate amount of the Dollar
Equivalent of the Revolving Credit Exposure and the Foreign Currency Sublimits
and the Maximum Foreign Currency Sublimit then outstanding (after giving effect
to any Loans made or repaid or Letters of Credit issued, drawn or expired on
such date) and (ii) notify the Lenders and the Borrower of the results of such
determination.

                                   ARTICLE II

                                   THE CREDITS

                  SECTION 2.01. Credit Commitments. (a) Subject to the terms and
conditions hereof, (i) each Term B Lender severally agrees to make a Term B Loan
in Dollars to the Borrower on the Effective Date in a principal amount not
exceeding its Term B Commitment, (ii) each Revolving Lender severally agrees to
make Revolving Dollar Loans to the Borrower from time to time during the
Revolving Credit Commitment Period and (iii) each Foreign Currency Lender
severally agrees to make Foreign Currency Loans to the Borrower from time to
time during the Revolving Credit Commitment Period. Amounts repaid or prepaid in
respect of Term B Loans may not be reborrowed. During the Revolving Credit
Commitment Period the Borrower may use the Revolving Credit Commitments by
borrowing, prepaying the Revolving Dollar Loans or Foreign Currency Loans in
whole or in part, and reborrowing, all in accordance

                                      -40-

<PAGE>

with the terms and conditions hereof. Notwithstanding anything to the contrary
contained in this Agreement, in no event may (A) Revolving Dollar Loans or
Foreign Currency Loans be borrowed under this Article II if, after giving effect
thereto (and to any concurrent repayment or prepayment of Loans), (i) the
Aggregate Revolving Credit Exposure would exceed the Total Revolving Credit
Commitment then in effect or (ii) the Revolving Credit Exposure of any Revolving
Lender would exceed such Revolving Lender's Revolving Credit Commitment and (B)
Foreign Currency Loans be borrowed under this Article II if, after giving effect
thereto (and to any concurrent repayment or prepayment of Foreign Currency
Loans), (i) the Aggregate Foreign Currency Exposure would exceed the Maximum
Foreign Currency Sublimit or (ii) the Foreign Currency Exposure of any Foreign
Currency Lender would exceed its Foreign Currency Sublimit.

                  (b)      The Revolving Loans and Term B Loans may from time to
time be (i) Eurocurrency Loans, (ii) ABR Loans if such Loans are not Foreign
Currency Loans or (iii) a combination thereof, as determined by the Borrower and
notified to the Administrative Agent in accordance with Sections 2.02 and 2.03;
provided that no such Loan shall be made as or converted to a Eurocurrency Loan
after the day that is one month prior to the Revolving Credit Maturity Date or
the Term B Loan Maturity Date, as applicable.

                  (c)      Each Loan (other than a Swingline Loan or Foreign
Currency Loan) shall be made as part of a Borrowing consisting of Loans of the
same Class and Type made by the Lenders ratably in accordance with their
respective Commitments of the applicable Class. The failure of any Lender to
make any Loan required to be made by it shall not relieve any other Lender of
its obligations hereunder; provided that the Commitments of the Lenders are
several and no Lender shall be responsible for any other Lender's failure to
make Loans as required.

                  SECTION 2.02. Procedure for Borrowing. (a) The Borrower may
borrow under the Revolving Credit Commitments (subject to the limitations in
Section 2.01(a)) or the Term B Commitments by giving the Administrative Agent
notice substantially in the form of Exhibit B (a "Borrowing Request"), which
notice must be received by the Administrative Agent prior to (a) 11:00 a.m., New
York City time, three Business Days prior to the requested Borrowing Date, in
the case of a Eurocurrency Borrowing, or (b) 11:00 a.m., New York City time, on
the Business Day prior to the requested Borrowing Date, in the case of an ABR
Borrowing. The Borrowing Request for each Borrowing shall specify (i) whether
the requested Borrowing is to be a Revolving Credit Borrowing, a Term B
Borrowing or a Foreign Currency Borrowing, (ii) the amount to be borrowed in the
currency of such Borrowing, (iii) the requested Borrowing Date (which must be
the Effective Date, in the case of a Term B Borrowing), (iv) whether the
Borrowing is to be of Eurocurrency Loans or ABR Loans, (v) if the Borrowing is
to be of Eurocurrency Loans, the length of the initial Interest Period therefor,
and (vi) the location and number of the Borrower's account to which funds are to
be disbursed, which shall comply with the requirements of this Agreement. If no
election as to the Type of Borrowing is specified, then the requested Borrowing
shall be an ABR Borrowing. If no Interest Period is specified with respect to
any requested Eurocurrency Borrowing, then the Borrower shall be deemed to have
selected an Interest Period of one month's duration.

                                      -41-

<PAGE>

                  (b)      Each Borrowing shall be in a minimum aggregate
principal amount of (i) $5.0 million, L5.0 million or E5.0 million, as
applicable, or an integral multiple of $1.0 million, L1.0 million or E1.0
million, as applicable, in excess thereof or (ii) in the case of a Revolving
Credit Borrowing, if less, the aggregate amount of the then Available Revolving
Credit Commitments.

                  (c)      Upon receipt of the Term B Borrowing Request, the
Administrative Agent shall promptly notify each Term B Lender of the aggregate
amount of the Term B Borrowing and of the amount of such Term B Lender's pro
rata portion thereof, which shall be based on their respective Term B
Commitments. Each Term B Lender will make the amount of its pro rata portion of
the Term B Borrowing available to the Administrative Agent for the account of
the Borrower at the New York office of the Administrative Agent specified in
Section 10.01 prior to 10:00 a.m., New York City time, on the Effective Date in
funds immediately available to the Administrative Agent. Amounts so received by
the Administrative Agent will promptly be made available to the Borrower by the
Administrative Agent crediting the account of the Borrower on the books of such
office with the aggregate of the amounts made available to the Administrative
Agent by the Term B Lenders and in like funds as received by the Administrative
Agent.

                  (d)      After the Effective Date, upon receipt of a Revolving
Credit Borrowing Request (other than a Revolving Borrowing Request in respect of
a Foreign Currency Borrowing), the Administrative Agent shall promptly notify
each Revolving Lender of the aggregate amount of such Revolving Credit Borrowing
and of the amount of such Revolving Lender's pro rata portion thereof, which
shall be based on the respective Available Revolving Credit Commitments of all
the Revolving Lenders. Each Revolving Lender will make the amount of its pro
rata portion of each such Revolving Credit Borrowing available to the
Administrative Agent for the account of the Borrower at the New York office of
the Administrative Agent specified in Section 10.01 prior to 12:00 p.m., New
York City time, on the Borrowing Date requested by the Borrower in funds
immediately available to the Administrative Agent. Amounts so received by the
Administrative Agent will promptly be made available to the Borrower by the
Administrative Agent crediting the account of the Borrower on the books of such
office with the aggregate of the amounts made available to the Administrative
Agent by the Revolving Lenders and in like funds as received by the
Administrative Agent; provided that if on the Borrowing Date of any Revolving
Loans to be made to the Borrower, any Swingline Loans made to the Borrower or LC
Disbursements for the account of the Borrower shall be then outstanding, the
proceeds of such Revolving Loans shall first be applied to pay in full such
Swingline Loans or LC Disbursements, with any remaining proceeds to be made
available to the Borrower as provided above; and provided, further, that ABR
Revolving Loans made to finance the reimbursement of an LC Disbursement as
provided in Section 2.07(e) shall be remitted by the Administrative Agent to the
Issuing Bank.

                  (e)      After the Effective Date, upon receipt of a Revolving
Credit Borrowing Request in respect of a Foreign Currency Borrowing, the
Administrative Agent shall promptly notify each Foreign Currency Lender of the
requested currency and the aggregate amount (in both the requested currency and
the Dollar Equivalent thereof) of such Foreign Currency Bor-

                                      -42-

<PAGE>

rowing and of the amount of such Foreign Currency Lender's Foreign Currency
Ratable Portion thereof. Each Foreign Currency Lender will make the amount of
its Foreign Currency Ratable Portion of each such Foreign Currency Borrowing in
the requested currency available to the Administrative Agent for the account of
the Borrower at the New York office of the Administrative Agent specified in
Section 10.01 prior to 12:00 p.m., New York City time, on the Borrowing Date
requested by the Borrower in funds immediately available to the Administrative
Agent. Amounts so received by the Administrative Agent will promptly be made
available to the Borrower by the Administrative Agent crediting the account of
the Borrower on the books of such office with the aggregate of the amounts made
available to the Administrative Agent by the Foreign Currency Lenders and in
like funds as received by the Administrative Agent.

                  SECTION 2.03. Conversion and Continuation Options for Loans.
(a) The Borrower may elect from time to time to convert (i) Eurocurrency Loans
that are in Dollars to ABR Loans, by giving the Administrative Agent prior
notice of such election not later than 11:00 a.m., New York City time, on the
Business Day prior to a requested conversion or (ii) ABR Loans to Eurocurrency
Loans by giving the Administrative Agent prior notice of such election not later
than 11:00 a.m., New York City time, three Business Days prior to a requested
conversion; provided that if any such conversion of Eurocurrency Loans is made
other than on the last day of an Interest Period with respect thereto, the
Borrower shall pay any amounts due to the Lenders pursuant to Section 2.18 as a
result of such conversion. Any such notice of conversion to Eurocurrency Loans
shall specify the length of the initial Interest Period or Interest Periods
therefor. Upon receipt of any such notice the Administrative Agent shall
promptly notify each Lender thereof. All or any part of the outstanding
Eurocurrency Loans or ABR Loans may be converted as provided herein; provided
that (i) no Loan may be converted into a Eurocurrency Loan when any Default or
Event of Default has occurred and is continuing, and (ii) no Loan may be
converted into a Eurocurrency Loan after the date that is one month prior to the
Revolving Credit Maturity Date or the Term B Loan Maturity Date, as applicable.

                  (b)      Any Eurocurrency Loans may be continued as such upon
the expiration of the then current Interest Period with respect thereto by the
Borrower giving prior notice to the Administrative Agent, not later than 11:00
a.m., New York City time, three Business Days prior to a requested continuation
setting forth the length of the next Interest Period to be applicable to such
Loans; provided that no Eurocurrency Loan (other than a Foreign Currency Loan)
may be continued as such (i) when any Default or Event of Default has occurred
and is continuing, and (ii) after the date that is one month prior to the
Revolving Credit Maturity Date or the Term B Loan Maturity Date, as applicable;
and provided, further, that if the Borrower shall fail to give any required
notice as described above in this Section 2.03 or if such continuation is not
permitted pursuant to the preceding proviso, then such Loans shall be
automatically converted to ABR Loans on the last day of such then expiring
Interest Period (in which case the Administrative Agent shall notify the
Borrower of such conversion).

                  (c)      In connection with any Eurocurrency Loans, there
shall be no more than ten (10) Interest Periods outstanding at any time.

                  (d)      This Section shall not apply to Swingline Loans.

                                      -43-

<PAGE>

                  SECTION 2.04. Provisions Relating to Foreign Currency Loans.
(a) At any time (i) after the occurrence and during the continuance of any
Default or Event of Default or an Event of Termination, the Administrative Agent
may (and, upon the request of any Foreign Currency Lender, shall), or (ii) upon
the replacement of any Foreign Currency Loan with a Revolving Dollar Loan
pursuant to Section 2.13 or 2.15 or this Section the Administrative Agent shall,
demand that each Revolving Dollar Lender pay in Dollars to the Administrative
Agent, for the account of the Foreign Currency Lenders, in the manner provided
in clause (b) below, such Revolving Dollar Lender's Pro Rata Percentage of the
Dollar Equivalent (utilizing, with respect to each Foreign Currency Loan, the
Exchange Rate at the time such Foreign Currency Loan was borrowed) of the
Aggregate Foreign Currency Exposure and related accrued but unpaid interest at
such time, which demand shall be made through the Administrative Agent, shall be
in writing and shall specify the outstanding principal amount and interest of
Foreign Currency Loans.

                  (b)      Each demand referred to in clause (a) above shall be
delivered to each Revolving Dollar Lender, together with a statement prepared by
the Administrative Agent setting forth in reasonable detail the Aggregate
Foreign Currency Exposure and Dollar Equivalent thereof (utilizing, with respect
to each Foreign Currency Loan, the Exchange Rate at the time such Foreign
Currency Loan was borrowed), and whether or not the conditions set forth in
Section 4.03 or 2.01(a) shall be satisfied (which conditions the Revolving
Lenders hereby irrevocably waive), each Revolving Dollar Lender shall, before
11:00 a.m. (New York time) on the Business Day next succeeding the date of such
Revolving Dollar Lender's receipt of such demand, make available to the
Administrative Agent, in immediately available funds in Dollars for the account
of each Foreign Currency Lender, its Pro Rata Percentage of the Dollar
Equivalent (utilizing, with respect to each Foreign Currency Loan, the Exchange
Rate at the time such Foreign Currency Loan was borrowed) of the Aggregate
Foreign Currency Exposure and related accrued but unpaid interest at such time
(with respect to each such Revolving Dollar Lender, its "Dollar Portion"). Upon
such payment by a Revolving Dollar Lender, such Revolving Dollar Lender shall,
except as provided in clause (c) below, be deemed to have made a Revolving
Dollar Loan to the Borrower in the principal amount of such payment and bearing
interest at the Alternate Base Rate. The Administrative Agent shall forward such
payments by the Revolving Dollar Lenders (or cause such payments to be
forwarded) to the Foreign Currency Lenders according to their respective Foreign
Currency Sublimits. To the extent that any Revolving Dollar Lender fails to make
its Dollar Portion available to the Administrative Agent for the accounts of the
Foreign Currency Lenders, the Borrower agrees to pay such Dollar Portion on
demand in immediately available funds in Dollars for the benefit of the Foreign
Currency Lenders (as payment for the Foreign Currency Loans). As of the date of
any such demand, the Foreign Currency Loans (together with any interest then
accrued thereon) shall, immediately and without further action, become due and
payable and, to the extent not otherwise repaid hereunder, the Borrower agrees,
as a separate and independent obligation, to pay to the Administrative Agent,
for the account of any Foreign Currency Lender entitled thereto, any amounts to
which any Foreign Currency Lender may be entitled pursuant to Section 2.18 or
Section 10.19 and which shall not otherwise have been repaid by the Revolving
Dollar Lenders pursuant to this Section 2.04.

                  (c)      Upon the occurrence of an Event of Default under
Section 7.01(i), the Foreign Currency Loans shall automatically, immediately,
and without notice of any kind, convert

                                      -44-
<PAGE>

to Revolving Dollar Loans (based upon the Dollar Equivalent of the Aggregate
Foreign Currency Exposure at the time of the occurrence of such Event
of Default) and bearing interest at the rate applicable to Revolving Dollar
Loans bearing interest based on the Alternate Base Rate, whereupon each
Revolving Dollar Lender shall acquire, without recourse or warranty, an
undivided participation in each Foreign Currency Loan otherwise required to be
repaid by such Revolving Dollar Lender pursuant to clause (b) above, which
participation shall be in a principal amount equal to such Revolving Dollar
Lender's Dollar Portion by paying to the Administrative Agent for the benefit of
the Foreign Currency Lenders on the date on which such Revolving Dollar Lender
would otherwise have been required to make a payment in respect of such Foreign
Currency Loan pursuant to clause (b) above, in immediately available funds in
Dollars, an amount equal to such Revolving Lender's Dollar Portion. If all or
part of such amount is not in fact made available by such Revolving Dollar
Lender to the Administrative Agent on such date, the Foreign Currency Lenders
shall be entitled to recover any such unpaid amount on demand from such
Revolving Dollar Lender together with interest accrued from such date at the
Alternate Base Rate. As of the date of any such Event of Default under Section
7.01(i), all Foreign Currency Loans (together with any interest then accrued
thereon) shall, immediately and without further action, become due and payable
and, to the extent not otherwise repaid hereunder, the Borrower agrees, as a
separate and independent obligation, to pay to the Administrative Agent, for the
account of any Foreign Currency Lender entitled thereto, any amounts to which
any Foreign Currency Lender may be entitled to pursuant to Section 2.18 or
Section 10.19 and which shall not otherwise have been repaid by the Revolving
Dollar Lenders pursuant to this Section 2.04.

                  (d)      From and after the date on which any Revolving Lender
(i) is deemed to have made a Revolving Dollar Loan pursuant to clause (b) above
with respect to any Foreign Currency Loan or (ii) purchases an undivided
participation interest in a Foreign Currency Loan pursuant to clause (c) above,
the Administrative Agent and the Foreign Currency Lenders shall promptly
distribute to such Revolving Dollar Lender such Revolving Dollar Lender's Pro
Rata Percentage of all payments of principal amount and interest received by the
Administrative Agent or the Foreign Currency Lenders on account of such Foreign
Currency Loan in excess of those received pursuant to clause (b) or (c) above.

                  (e)      Notwithstanding the foregoing, a Revolving Dollar
Lender shall not have any obligation to acquire a participation in a Foreign
Currency Loan pursuant to the foregoing paragraphs if a Default or Event of
Default or Event of Termination shall have occurred and be continuing at the
time such Foreign Currency Loan was made and such Revolving Dollar Lender shall
have notified the Foreign Currency Lenders in writing prior to the time such
Foreign Currency Loan was made, that such Default or Event of Default or such
Event of Termination has occurred and that such Revolving Dollar Lender will not
acquire participations in Foreign Currency Loans made while such Default or
Event of Default or such Event of Termination is continuing.

                  SECTION 2.05. Swingline Loans. (a) Subject to the terms and
conditions hereof, the Swingline Lender agrees to make swingline loans
(individually, a "Swingline Loan" and collectively, the "Swingline Loans") to
the Borrower from time to time during the Revolving

                                      -45-
<PAGE>

Credit Commitment Period in accordance with the procedures set forth in this
Section 2.05; provided that (i) the aggregate principal amount of all Swingline
Loans shall not exceed $15.0 million at any one time outstanding, (ii) the
principal amount of any Borrowing of Swingline Loans may not exceed the
aggregate amount of the Available Revolving Credit Commitments of all Revolving
Lenders immediately prior to such Borrowing or result in the Aggregate Revolving
Credit Exposure then outstanding exceeding the Total Revolving Credit
Commitments then in effect, and (iii) in no event may Swingline Loans be
borrowed hereunder if (x) a Default or Event of Default or Event of Termination
shall have occurred and be continuing and (y) such Default or Event of Default
or Event of Termination shall not have been subsequently cured or waived.
Amounts borrowed under this Section 2.05 may be repaid and, up to but excluding
the Revolving Credit Maturity Date, reborrowed. All Swingline Loans shall at all
times be ABR Loans. The Borrower shall give the Administrative Agent notice of
any Swingline Loan requested hereunder (which notice must be received by the
Administrative Agent prior to 11:00 a.m., New York City time, on the requested
Borrowing Date) specifying (A) the amount to be borrowed, and (B) the requested
Borrowing Date. Upon receipt of such notice, the Administrative Agent shall
promptly notify the Swingline Lender of the aggregate amount of such Borrowing.
Not later than 2:00 p.m., New York City time, on the Borrowing Date specified in
such notice the Swingline Lender shall make such Swingline Loan available to the
Administrative Agent for the account of the Borrower at the office of the
Administrative Agent set forth in Section 10.01 in funds immediately available
to the Administrative Agent. Amounts so received by the Administrative Agent
will promptly be made available to the Borrower by the Administrative Agent
crediting the account of the Borrower on the books of such office with the
amount made available to the Administrative Agent by the Swingline Lender (or,
in the case of a Swingline Loan made to finance the reimbursement of an LC
Disbursement as provided in Section 2.07(e), by remittance to the Issuing Bank)
and in like funds as received by the Administrative Agent. Each Borrowing
pursuant to this Section 2.05 shall be in a minimum principal amount of $500,000
or an integral multiple of $100,000 in excess thereof.

                  (b)      Notwithstanding the occurrence of any Default or
Event of Default or Event of Termination or noncompliance with the conditions
precedent set forth in Article IV or the minimum borrowing amounts specified in
Section 2.02, if any Swingline Loan shall remain outstanding at 10:00 a.m., New
York City time, on the seventh Business Day following the Borrowing Date thereof
and if by such time on such seventh Business Day the Administrative Agent shall
have received neither (i) a Borrowing Request delivered by the Borrower pursuant
to Section 2.02 requesting that Revolving Loans be made pursuant to Section 2.01
on the immediately succeeding Business Day in an amount at least equal to the
aggregate principal amount of such Swingline Loan, nor (ii) any other notice
satisfactory to the Administrative Agent indicating the Borrower's intent to
repay such Swingline Loan on the immediately succeeding Business Day with funds
obtained from other sources, the Administrative Agent shall be deemed to have
received a Borrowing Request from the Borrower pursuant to Section 2.02
requesting that ABR Revolving Loans be made pursuant to Section 2.01 on such
immediately succeeding Business Day in an amount equal to the amount of such
Swingline Loan, and the procedures set forth in Section 2.02 shall be followed
in making such ABR Revolving Loans; provided that for the purposes of
determining each Revolving Lender's Pro Rata Percentage with respect to such
Borrowing, the Swingline Loan to be repaid with the proceeds of such Borrowing
shall be deemed to not

                                      -46-
<PAGE>

be outstanding. The proceeds of such ABR Revolving Loans shall be applied to
repay such Swingline Loan.

                  (c)      If, for any reason, ABR Revolving Loans may not be,
or are not, made pursuant to paragraph (b) of this Section 2.05 to repay any
Swingline Loan as required by such paragraph, effective on the date such ABR
Revolving Loans would otherwise have been made, each Revolving Lender severally,
unconditionally and irrevocably agrees that it shall, without regard to the
occurrence of any Default or Event of Default, purchase a participating interest
in such Swingline Loan ("Unrefunded Swingline Loan") in an amount equal to such
Revolving Lender's Pro Rata Percentage of the aggregate amount of the ABR
Revolving Loans which would otherwise have been made pursuant to paragraph (b)
of this Section 2.05. Each Revolving Lender will immediately transfer to the
Administrative Agent, in immediately available funds, the amount of its
participation, and the proceeds of such participations shall be distributed by
the Administrative Agent to the Swingline Lender. All payments by the Revolving
Lenders in respect of Unrefunded Swingline Loans and participations therein
shall be made in accordance with Section 2.14.

                  (d)      Notwithstanding the foregoing, a Lender shall not
have any obligation to acquire a participation in a Swingline Loan pursuant to
the foregoing paragraphs if a Default or Event of Default or Event of
Termination shall have occurred and be continuing at the time such Swingline
Loan was made and such Lender shall have notified the Swingline Lender in
writing prior to the time such Swingline Loan was made, that such Default or
Event of Default or such Event of Termination has occurred and that such Lender
will not acquire participations in Swingline Loans made while such Default or
Event of Default or such Event of Termination is continuing.

                  SECTION 2.06. Optional and Mandatory Prepayments of Loans;
Repayments of Term B Loans. (a) The Borrower may at any time and from time to
time prepay the Loans (subject, in the case of Eurocurrency Loans, to compliance
with the terms of Section 2.18), in whole or in part, subject to Section
2.06(e), upon irrevocable notice to the Administrative Agent not later than
12:00 noon, New York City time, two Business Days prior to the date of such
prepayment, specifying (i) the date and amount of prepayment, and (ii) the Class
of Loans to be prepaid and whether the prepayment is of Eurocurrency Loans, ABR
Loans or a combination thereof (including in the case of Eurocurrency Loans, the
Borrowing to which such prepayment is to be applied and, if of a combination
thereof, the amount allocable to each). Upon receipt of any such notice the
Administrative Agent shall promptly notify each relevant Lender thereof. If any
such notice is given, the amount specified in such notice shall be due and
payable on the date specified therein, together with accrued interest to such
date on the amount prepaid. Partial prepayments of Loans (other than Swingline
Loans) shall be in an aggregate principal amount of $5.0 million, (pound)5.0
million or (euro)5.0 million, as applicable, or a whole multiple of $1.0
million, (pound)1.0 million or (euro)1.0 million, as applicable, in excess
thereof (or, if less, the remaining outstanding principal amount thereof).
Partial prepayments of Swingline Loans shall be in an aggregate principal amount
of $500,000 or a whole multiple of $100,000 in excess thereof (or, if less, the
remaining outstanding principal amount thereof).

                                      -47-

<PAGE>

                  (b)      In the event and on such occasion that the Aggregate
Revolving Credit Exposure exceeds the Total Revolving Credit Commitment, the
Borrower shall prepay Revolving Credit Borrowings or Swingline Borrowings (or,
if no such Borrowings are outstanding, deposit cash collateral in the account
established with the Administrative Agent pursuant to Section 2.07(j)) in an
aggregate amount equal to such excess. In the event and on such occasion that
the Aggregate Foreign Currency Exposure exceeds the Maximum Foreign Currency
Sublimit, the Borrower shall prepay Foreign Currency Borrowings in an aggregate
amount equal to such excess.

                  (c)      (i) If, subsequent to the Effective Date, either
Parent Guarantor or the Borrower shall issue any Equity Interests or Equity
Rights (it being understood that the issuance of debt securities convertible
into, or exchangeable or exercisable for, any Equity Interest or Equity Right
shall be governed by Section 2.06(c)(ii) below) (other than any Excluded Equity
Issuance) (each, an "Equity Issuance"), 50% of the Net Proceeds thereof shall be
applied immediately after receipt thereof toward the prepayment of the Term B
Loans in accordance with Section 2.06(e) below.

                  (ii)     If, subsequent to the Effective Date, either Parent
Guarantor, the Borrower or any of the Restricted Subsidiaries shall incur or
permit the incurrence of any Indebtedness (including pursuant to debt securities
which are convertible into, or exchangeable or exercisable for, any Equity
Interest or Equity Rights) (other than Excluded Debt Issuances) (each, a "Debt
Incurrence"), 100% of the Net Proceeds thereof shall be applied immediately
after receipt thereof toward the prepayment of the Term B Loans in accordance
with Section 2.06(e) below; provided that if at the time of such Debt
Incurrence, the Total Leverage Ratio as of the last Test Period for which a
Compliance Certificate has been delivered determined on a pro forma basis after
giving effect to such Debt Incurrence is less than 3.0x, then only 50% of the
Net Proceeds thereof shall be so applied.

                  (iii)    If, subsequent to the Effective Date, either Parent
Guarantor, the Borrower or any of the Restricted Subsidiaries shall receive Net
Proceeds from any Asset Sale, 100% of such Net Proceeds shall be applied
immediately after receipt thereof toward the prepayment of the Term B Loans in
accordance with Section 2.06(e) below; provided that (x) the Net Proceeds from
Asset Sales permitted by Section 6.05 shall not be required to be applied as
provided herein if and to the extent that (1) no Default or Event of Default
then exists or would arise therefrom and (2) the Borrower delivers an officers'
certificate to the Administrative Agent on or prior to the date of such Asset
Sale stating that such Net Proceeds shall be reinvested in assets of the
Borrower or any Restricted Subsidiary otherwise permitted to be acquired
pursuant to this Agreement in each case within 270 days (subject to Section
6.05(vii), if applicable) following the date of such Asset Sale (which
certificate shall set forth the estimates of the proceeds to be so expended),
(y) all such Net Proceeds shall be held in the Collateral Account and released
therefrom only in accordance with the terms of the Security Agreement, and (z)
if all or any portion of such Net Proceeds not so applied as provided herein is
not so used within such 270-day period (subject to Section 6.05(vii), if
applicable), such remaining portion shall be applied on the last day of such
period as specified in this subsection (c)(iii); provided, further, if the
Property subject to such Asset Sale constituted Collateral under the Security
Documents, then any capital assets pur-

                                      -48-

<PAGE>

chased with the Net Proceeds thereof pursuant to this subsection shall be
mortgaged or pledged, as the case may be, to the Collateral Agent, for its
benefit and for the benefit of the other Secured Parties in accordance with
Section 5.11.

                  (iv)     If, subsequent to the Effective Date, either Parent
Guarantor, the Borrower or any of the Restricted Subsidiaries shall receive
proceeds from insurance recoveries in respect of any Destruction or any proceeds
or awards in respect of any Taking, 100% of the Net Proceeds thereof shall be
applied immediately after receipt thereof toward the prepayment of the Term B
Loans in accordance with Section 2.06(e) below; provided that (x) so long as no
Default or Event of Default then exists or would arise therefrom, such Net
Proceeds shall not be required to be so applied to the extent that the Borrower
has delivered an officers' certificate to the Administrative Agent promptly
following the receipt of such Net Proceeds stating that such proceeds shall be
used to (1) repair, replace or restore any Property in respect of which such Net
Proceeds were paid or (2) fund the substitution of other Property used or usable
in the business of the Borrower or the Restricted Subsidiaries, in each case
within 270 days following the date of the receipt of such Net Proceeds, (y) all
such Net Proceeds shall be held in the Collateral Account and released therefrom
only in accordance with the terms of the Security Agreement, and (z) if all or
any portion of such Net Proceeds not required to be applied to the prepayment of
Term B Loans pursuant to the preceding proviso is not so used within 270 days
after the date of the receipt of such Net Proceeds, such remaining portion shall
be applied on the last day of such period as specified in this subsection
(c)(iv); provided, further, if the Property subject to such Destruction or
Taking constituted Collateral under the Security Documents, then any replacement
or substitution Property purchased with the Net Proceeds thereof pursuant to
this subsection shall be mortgaged or pledged, as the case may be, to the
Collateral Agent, for its benefit and for the benefit of the other Secured
Parties in accordance with Section 5.11.

                  (v)      If, for any Fiscal Year of the Borrower commencing
with its Fiscal Year ending on December 31, 2004, there shall be Excess Cash
Flow of the Borrower and the Restricted Subsidiaries for such Fiscal Year, 50%
of such Excess Cash Flow shall be applied not later than 150 days after the end
of such Fiscal Year toward prepayment of the Term B Loans in accordance with
Section 2.06(e) below; provided that for the Fiscal Year ending on December 31,
2004, Excess Cash Flow to be applied toward the prepayment of the Term B Loans
pursuant to this Section 2.06(c)(v) shall be reduced by Foreign Excess Cash
Flow, if positive.

                  (d)      The Term B Loans shall be repaid in consecutive
quarterly installments on the dates set forth below (each such day, an
"Installment Payment Date"), commencing on December 31, 2003, in an aggregate
amount equal to the amount specified below for each such Installment Payment
Date.

<TABLE>
<CAPTION>
Installment Payment Date                             Installment Amount
------------------------                             ------------------
<S>                                                  <C>
December 31, 2003                                     $     775,000.00
March 31, 2004                                        $     775,000.00
June 30, 2004                                         $     775,000.00
September 30, 2004                                    $     775,000.00
December 31, 2004                                     $     775,000.00
</TABLE>

                                      -49-

<PAGE>

<TABLE>
<CAPTION>
Installment Payment Date                             Installment Amount
------------------------                             ------------------
<S>                                                  <C>
March 31, 2005                                        $     775,000.00
June 30, 2005                                         $     775,000.00
September 30, 2005                                    $     775,000.00
December 31, 2005                                     $     775,000.00
March 31, 2006                                        $     775,000.00
June 30, 2006                                         $     775,000.00
September 30, 2006                                    $     775,000.00
December 31, 2006                                     $     775,000.00
March 31, 2007                                        $     775,000.00
June 30, 2007                                         $     775,000.00
September 30, 2007                                    $     775,000.00
December 31, 2007                                     $     775,000.00
March 31, 2008                                        $     775,000.00
June 30, 2008                                         $     775,000.00
September 30, 2008                                    $     775,000.00
December 31, 2008                                     $     775,000.00
March 31, 2009                                        $     775,000.00
June 30, 2009                                         $     775,000.00
Term B Loan Maturity Date                             $ 292,175,000.00
</TABLE>

                  (e)      Prepayments of Term B Loans pursuant to Sections
2.06(a) and (c) shall be applied pro rata to remaining installments of principal
of such Term B Loans. Except as otherwise may be directed by the Borrower, any
prepayment of Loans pursuant to this Section 2.06 shall be applied, first, to
any ABR Loans then outstanding and the balance of such prepayment, if any, to
the Eurocurrency Loans then outstanding.

                  (f)      If on any day on which Loans would otherwise be
required to be prepaid pursuant to this Section 2.06, but for the operation of
this Section 2.06(f) (each a "Prepayment Date"), the amount of such required
prepayment exceeds the then outstanding aggregate principal amount of ABR Loans
which are of the Type required to be prepaid and no Default or Event of Default
exists or is continuing, then on such Prepayment Date, (i) the Borrower shall
deposit Dollars into the Collateral Account in an amount equal to such excess,
and only the outstanding ABR Loans which are of the Type required to be prepaid
shall be required to be prepaid on such Prepayment Date, and (ii) on the last
day of each Interest Period after such Prepayment Date in effect with respect to
a Eurocurrency Loan which is of the Type required to be prepaid, the
Administrative Agent is irrevocably authorized and directed to apply funds from
the Collateral Account (and liquidate investments held in the Collateral Account
as necessary) to prepay such Eurocurrency Loans for which the Interest Period is
then ending to the extent funds are available in the Collateral Account. For
avoidance of doubt, all such Eurocurrency Loans shall continue to bear interest
until repaid.

                  (g)      Any optional prepayment of Term B Loans pursuant to
Section 2.06(a) (other than with the proceeds from any sale of Equity Interests
of Bioglan or any sale of Bioglan through merger, consolidation or any sale of
its assets) and any mandatory prepayment of Term

                                      -50-

<PAGE>

B Loans pursuant to Section 2.06(c)(ii) during the periods set forth below shall
be made with the premium (expressed as a percentage of the principal amount
being prepaid) set forth opposite the periods below:

<TABLE>
<CAPTION>

            Period                                      Prepayment Premium
            ------                                      ------------------
<S>                                                     <C>
Effective Date - September 25, 2004                            2.0%
September 26, 2004 - September 25, 2005                        1.0%
</TABLE>

                  SECTION 2.07. Letters of Credit.

                  (a)      General. Subject to the terms and conditions set
forth herein, the Borrower may request the issuance of Letters of Credit for its
own account, in a form reasonably acceptable to the Administrative Agent and the
Issuing Bank, at any time and from time to time during the Revolving Credit
Commitment Period. In the event of any inconsistency between the terms and
conditions of this Agreement and the terms and conditions of any form of letter
of credit application or other agreement submitted by the Borrower to, or
entered into by the Borrower with, the Issuing Bank relating to any Letter of
Credit, the terms and conditions of this Agreement shall control.

                  (b)      Notice of Issuance, Amendment, Renewal, Extension;
Certain Conditions. To request the issuance of a Letter of Credit (or the
amendment, renewal or extension of an outstanding Letter of Credit), the
Borrower shall hand deliver or telecopy (or transmit by electronic
communication, if arrangements for doing so have been approved by the Issuing
Bank) to the Issuing Bank and the Administrative Agent (reasonably in advance of
the requested date of issuance, amendment, renewal or extension) a notice
requesting the issuance of a Letter of Credit, or identifying the Letter of
Credit to be amended, renewed or extended, and specifying the date of issuance,
amendment, renewal or extension (which shall be a Business Day), the date on
which such Letter of Credit is to expire (which shall comply with paragraph (c)
of this Section), the amount of such Letter of Credit, the name and address of
the beneficiary thereof and such other information as shall be necessary to
prepare, amend, renew or extend such Letter of Credit. If requested by the
Issuing Bank, the Borrower also shall submit a letter of credit application on
the Issuing Bank's standard form in connection with any request for a Letter of
Credit. A Letter of Credit shall be issued, amended, renewed or extended only if
(and upon issuance, amendment, renewal or extension of each Letter of Credit the
Borrower shall be deemed to represent and warrant that), after giving effect to
such issuance, amendment, renewal or extension, (i) the LC Exposure shall not
exceed $25.0 million and (ii) the Aggregate Revolving Credit Exposure shall not
exceed the Total Revolving Credit Commitment. With respect to any Letter of
Credit which contains any "evergreen" automatic renewal provision, the Issuing
Bank shall be deemed to have consented to any such extension or renewal provided
that all of the requirements of this Section 2.07 are met and no Default or
Event of Default exists and is continuing.

                  (c)      Expiration Date. Each Letter of Credit shall expire
at or prior to the close of business on the earlier of (i) the date one year
after the date of the issuance of such Letter of Credit (or, in the case of any
renewal or extension thereof, one year after such renewal or extension) and (ii)
the date that is five Business Days prior to the Revolving Credit Maturity Date.

                                      -51-

<PAGE>

                  (d)      Participations. By the issuance of a Letter of Credit
(or an amendment to a Letter of Credit increasing the amount thereof) and
without any further action on the part of the Issuing Bank or the Lenders, the
Issuing Bank hereby grants to each Revolving Lender, and each Revolving Lender
hereby acquires from the Issuing Bank, a participation in such Letter of Credit
equal to such Revolving Lender's Commitment Percentage of the aggregate amount
available to be drawn under such Letter of Credit. In consideration and in
furtherance of the foregoing, each Revolving Lender hereby absolutely and
unconditionally agrees to pay to the Administrative Agent, for the account of
the Issuing Bank, such Revolving Lender's Commitment Percentage of each LC
Disbursement made by the Issuing Bank and not reimbursed by the Borrower on the
date due as provided in paragraph (e) of this Section, or of any reimbursement
payment required to be refunded to the Borrower for any reason. Each Revolving
Lender acknowledges and agrees that its obligation to acquire participations
pursuant to this paragraph in respect of Letters of Credit is absolute and
unconditional and shall not be affected by any circumstance whatsoever,
including any amendment, renewal or extension of any Letter of Credit or the
occurrence and continuance of a Default or an Event of Default or reduction or
termination of the Revolving Credit Commitments, and that each such payment
shall be made without any offset, abatement, withholding or reduction
whatsoever.

                  (e)      Reimbursement. If the Issuing Bank shall make any LC
Disbursement in respect of a Letter of Credit, the Borrower shall reimburse such
LC Disbursement by paying to the Administrative Agent an amount equal to such LC
Disbursement not later than 12:00 noon, New York City time, if such payment is
made from the proceeds of Revolving Credit Loans, or 2:00 p.m., New York City
time, if such payment is made from cash or is made from the proceeds of a
Swingline Loan, on the date that such LC Disbursement is made, if the Borrower
shall have received notice of such LC Disbursement prior to 10:00 a.m., New York
City time, on such date, or, if such notice has not been received by the
Borrower prior to such time on such date, then not later than 12:00 noon, New
York City time, on (i) the Business Day that the Borrower receives such notice,
if such notice is received prior to 10:00 a.m., New York City time, on the day
of receipt, or (ii) the Business Day immediately following the day that the
Borrower receives such notice, if such notice is not received prior to such time
on the day of receipt; provided that the Borrower may, subject to the conditions
to borrowing set forth herein, request in accordance with Section 2.02 or 2.04
that such payment be financed with an ABR Revolving Borrowing or Swingline Loan
in an equivalent amount and, to the extent so financed, the Borrower's
obligation to make such payment shall be discharged and replaced by the
resulting ABR Revolving Borrowing or Swingline Loan. If the Borrower fails to
make such payment when due, the Administrative Agent shall notify each Revolving
Lender of the applicable LC Disbursement, the payment then due from the Borrower
in respect thereof and such Revolving Lender's Commitment Percentage thereof.
Promptly following receipt of such notice, each Revolving Lender shall pay to
the Administrative Agent its Commitment Percentage of the payment then due from
the Borrower, in the same manner as provided in Section 2.02 with respect to
Loans made by such Revolving Lender (and Section 2.02 shall apply, mutatis
mutandis, to the payment obligations of the Revolving Lenders), and the
Administrative Agent shall promptly pay to the Issuing Bank the amounts so
received by it from the Revolving Lenders. Promptly following receipt by the
Administrative Agent of any payment from the Borrower pursuant to this
paragraph, the Administrative Agent shall distribute such payment to the Issuing
Bank or, to the extent that Re-

                                      -52-

<PAGE>

volving Lenders have made payments pursuant to this paragraph to reimburse the
Issuing Bank, then to such Revolving Lenders and the Issuing Bank as their
interests may appear. Any payment made by a Revolving Lender pursuant to this
paragraph to reimburse the Issuing Bank for any LC Disbursement (other than the
funding of ABR Revolving Loans or a Swingline Loan as contemplated above) shall
not constitute a Loan and shall not relieve the Borrower of its obligation to
reimburse such LC Disbursement.

                  (f)      Obligations Absolute. The Borrower's obligation to
reimburse LC Disbursements as provided in paragraph (e) of this Section 2.07
shall be absolute, unconditional and irrevocable, and shall be performed
strictly in accordance with the terms of this Agreement under any and all
circumstances whatsoever and irrespective of (i) any lack of validity or
enforceability of any Letter of Credit or this Agreement, or any term or
provision therein, (ii) any draft or other document presented under a Letter of
Credit proving to be forged, fraudulent or invalid in any respect or any
statement therein being untrue or inaccurate in any respect, (iii) payment by
the Issuing Bank under a Letter of Credit against presentation of a draft or
other document that does not comply with the terms of such Letter of Credit, or
(iv) any other event or circumstance whatsoever, whether or not similar to any
of the foregoing, that might, but for the provisions of this Section, constitute
a legal or equitable discharge of, or provide a right of setoff against, the
Borrower's obligations hereunder. Neither the Administrative Agent, the
Revolving Lenders nor the Issuing Bank, nor any of their Related Parties, shall
have any liability or responsibility by reason of or in connection with the
issuance or transfer of any Letter of Credit or any payment or failure to make
any payment thereunder (irrespective of any of the circumstances referred to in
the preceding sentence), or any error, omission, interruption, loss or delay in
transmission or delivery of any draft, notice or other communication under or
relating to any Letter of Credit (including any document required to make a
drawing thereunder), any error in interpretation of technical terms or any
consequence arising from causes beyond the control of the Issuing Bank; provided
that the foregoing shall not be construed to excuse the Issuing Bank from
liability to the Borrower to the extent of any direct damages (as opposed to
consequential damages, claims in respect of which are hereby waived by the
Borrower to the extent permitted by applicable law) suffered by the Borrower
that are caused by the Issuing Bank's failure to exercise care when determining
whether drafts and other documents presented under a Letter of Credit comply
with the terms thereof. The parties hereto expressly agree that, in the absence
of gross negligence or willful misconduct on the part of the Issuing Bank (as
finally determined by a court of competent jurisdiction), the Issuing Bank shall
be deemed to have exercised care in each such determination. In furtherance of
the foregoing and without limiting the generality thereof, the parties agree
that, with respect to documents presented which appear on their face to be in
substantial compliance with the terms of a Letter of Credit, the Issuing Bank
may, in its sole discretion, either accept and make payment upon such documents
without responsibility for further investigation, regardless of any notice or
information to the contrary, or refuse to accept and make payment upon such
documents if such documents are not in strict compliance with the terms of such
Letter of Credit.

                  (g)      Disbursement Procedures. The Issuing Bank shall,
promptly following its receipt thereof, examine all documents purporting to
represent a demand for payment under a Letter of Credit. The Issuing Bank shall
promptly notify the Administrative Agent and the Borrower by telephone
(confirmed by telecopy) of such demand for payment and whether the Issu-

                                      -53-

<PAGE>

ing Bank has made or will make an LC Disbursement thereunder; provided that any
failure to give or delay in giving such notice shall not relieve the Borrower of
its obligation to reimburse the Issuing Bank and the Revolving Lenders with
respect to any such LC Disbursement.

                  (h)      Interim Interest. If the Issuing Bank shall make any
LC Disbursement, then, unless the Borrower shall reimburse such LC Disbursement
in full on the date such LC Disbursement is made, the unpaid amount thereof
shall bear interest, for each day from and including the date such LC
Disbursement is made to but excluding the date that the Borrower reimburses such
LC Disbursement, at the rate per annum then applicable to ABR Revolving Loans;
provided that if the Borrower fails to reimburse such LC Disbursement when due
pursuant to paragraph (e) of this Section 2.07, then Section 2.09(c) shall
apply. Interest accrued pursuant to this paragraph shall be for the account of
the Issuing Bank, except that interest accrued on and after the date of payment
by any Revolving Lender pursuant to paragraph (e) of this Section 2.07 to
reimburse the Issuing Bank shall be for the account of such Lender to the extent
of such payment.

                  (i)      Replacement of the Issuing Bank. The Issuing Bank may
be replaced at any time by written agreement among the Borrower, the
Administrative Agent, the replaced Issuing Bank and the successor Issuing Bank.
The Administrative Agent shall notify the Lenders of any such replacement of the
Issuing Bank. At the time any such replacement shall become effective, the
Borrower shall pay all unpaid fees accrued for the account of the replaced
Issuing Bank pursuant to Section 2.11(b). From and after the effective date of
any such replacement, (i) the successor Issuing Bank shall have all the rights
and obligations of the Issuing Bank under this Agreement with respect to Letters
of Credit to be issued thereafter and (ii) references herein to the term
"Issuing Bank" shall be deemed to refer to such successor or to any previous
Issuing Bank, or to such successor and all previous Issuing Banks, as the
context shall require. After the replacement of an Issuing Bank hereunder, the
replaced Issuing Bank shall remain a party hereto and shall continue to have all
the rights and obligations of an Issuing Bank under this Agreement with respect
to Letters of Credit issued by it prior to such replacement, but shall not be
required to issue additional Letters of Credit.

                  (j)      Cash Collateralization. If any Event of Default shall
occur and be continuing, on the Business Day that the Borrower receives notice
from the Administrative Agent or the Requisite Lenders (or, if the maturity of
the Loans has been accelerated, Revolving Lenders with LC Exposure representing
greater than 50% of the total LC Exposure) demanding the deposit of cash
collateral pursuant to this paragraph, the Borrower shall deposit in a
collateral account reasonably satisfactory to the Collateral Agent an amount in
cash equal to the LC Exposure as of such date plus any accrued and unpaid
interest thereon; provided that the obligation to deposit such cash collateral
shall become effective immediately, and such deposit shall become immediately
due and payable, without demand or other notice of any kind, upon the occurrence
of any Event of Default with respect to the Borrower described in clause (a) of
Section 7.01 or any Event of Default described in clause (i) of Section 7.01.
Each such deposit shall be held by the Collateral Agent as collateral for the
payment and performance of the Obligations of the Borrower under this Agreement
and the Borrower hereby grants the Collateral Agent a security interest in
respect of each such deposit and the collateral account in which such deposits
are held.

                                      -54-

<PAGE>

The Collateral Agent shall have exclusive dominion and control, including the
exclusive right of withdrawal, over the collateral account. Other than any
interest earned on the investment of such deposits, which investments shall be
made at the option and sole discretion of the Collateral Agent and at the
Borrower's risk and expense, such deposits shall not bear interest. Interest or
profits, if any, on such investments shall accumulate in the collateral account.
Moneys deposited in the collateral account pursuant to this Section 2.07(j)
shall be applied by the Collateral Agent to reimburse the Issuing Bank for LC
Disbursements for which it has not been reimbursed and, to the extent not so
applied, shall be held for the satisfaction of the reimbursement obligations of
the Borrower for the LC Exposure at such time or, if the maturity of the Loans
has been accelerated (but subject to the consent of Revolving Lenders with LC
Exposure representing greater than 50% of the total LC Exposure), be applied to
satisfy other obligations of the Borrower under this Agreement. If the Borrower
is required to provide an amount of cash collateral hereunder as a result of the
occurrence of an Event of Default, such amount (to the extent not applied as
aforesaid) shall be returned to the Borrower within three Business Days after
all Defaults or Events of Default have been cured or waived.

                  SECTION 2.08. Repayment of Loans; Evidence of Debt. (a) The
Borrower hereby unconditionally promises to pay to the Administrative Agent for
the account of the relevant Lenders (i) in respect of Revolving Credit
Borrowings and Foreign Currency Borrowings, on the Revolving Credit Maturity
Date (or such earlier date as, and to the extent that, such Revolving Dollar
Loan or Foreign Currency Loan becomes due and payable pursuant to Section 2.04,
2.05, 2.06, 2.12 or Article VII), the unpaid principal amount of each Revolving
Dollar Loan and Foreign Currency Loan and each Swingline Loan made to it by each
such Lender, in the applicable currency of such Loan, and (ii) in respect of
Term B Borrowings, on the Term B Loan Maturity Date (or such earlier date as,
and to the extent that, such Term B Loan becomes due and payable pursuant to
Section 2.06 or Article VII), the unpaid principal amount of each Term B Loan
held by each such Term B Lender. The Borrower hereby further agrees to pay
interest in immediately available funds at the applicable office of the
Administrative Agent (as specified in Section 2.14(a)) on the unpaid principal
amount of the Revolving Dollar Loans, Foreign Currency Loans, Swingline Loans
and Term B Loans made to it from time to time from the date hereof until payment
in full thereof at the rates per annum, and on the dates, set forth in Section
2.09. All payments required hereunder shall be made in the currency of such
Loan.

                  (b)      Each Lender shall maintain in accordance with its
usual practice an account or accounts evidencing the Indebtedness of the
Borrower to the appropriate lending office of such Lender resulting from each
Loan made by such lending office of such Lender from time to time, including the
amounts of principal and interest payable and paid to such lending office of
such Lender from time to time under this Agreement.

                  (c)      The Administrative Agent shall maintain the Register
pursuant to Section 10.04, and a subaccount for each Lender, in which Register
and subaccounts (taken together) shall be recorded (i) the amount of each such
Loan, the Class and Type of each such Loan and the Interest Period applicable
thereto, (ii) the amount of any principal or interest due and payable or to
become due and payable from the Borrower to each Lender hereunder in re-

                                      -55-

<PAGE>

spect of each such Loan and (iii) the amount of any sum received by the
Administrative Agent hereunder from the Borrower in respect of each such Loan
and each Lender's share thereof.

                  (d)      The entries made in the Register and accounts
maintained pursuant to paragraphs (b) and (c) of this Section 2.08 and the Notes
maintained pursuant to paragraph (e) of this Section 2.08 shall, to the extent
permitted by applicable law, be prima facie evidence of the existence and
amounts of the obligations of the Borrower therein recorded; provided, however,
that the failure of any Lender or the Administrative Agent to maintain such
account, such Register or such subaccount, as applicable, or any error therein,
shall not in any manner affect the obligation of the Borrower to repay (with
applicable interest) the Loans made to the Borrower by such Lender in accordance
with the terms of this Agreement.

                  (e)      The Loans of each Class made by each Lender to the
Borrower shall, if requested by the applicable Lender (which request shall be
made to the Administrative Agent), be evidenced by a single Note duly executed
on behalf of the Borrower, in substantially the form attached hereto as Exhibit
F-1 or F-2, as applicable, with the blanks appropriately filled, payable to the
order of such Lender.

                  SECTION 2.09. Interest Rates and Payment Dates. (a) Each
Eurocurrency Loan shall bear interest (computed on the basis of the actual
number of days elapsed over a year of 360 days) for each day during each
Interest Period with respect thereto at a rate per annum equal to:

                  (i)      in the case of a Eurocurrency Revolving Loan, (A) the
         LIBO Rate determined for such Interest Period, plus (B) the Applicable
         Rate; or

                  (ii)     in the case of a Eurocurrency Term B Loan, (A) the
         LIBO Rate determined for such Interest Period plus (B) the Applicable
         Rate.

                  (b)      Each ABR Loan (including each Swingline Loan) shall
bear interest (computed on the basis of the actual number of days elapsed over a
year of 365 or 366 days, as the case may be, or over a year of 360 days when the
Alternate Base Rate is determined by reference to clause (c) of the definition
of "Alternate Base Rate") at a rate per annum equal to the Alternate Base Rate
plus the Applicable Rate.

                  (c)      If all or a portion of (i) the principal amount of
any Loan, (ii) any interest payable thereon or (iii) any Fee or other amount
payable hereunder shall not be paid when due (whether at the stated maturity
thereof or by acceleration or otherwise), such overdue amount shall bear
interest at a rate per annum (the "Default Rate")which is (x) in the case of
overdue principal (except as otherwise provided in clause (y) below), the rate
that would otherwise be applicable thereto pursuant to the foregoing provisions
of this Section 2.09 plus 2.00% per annum or (y) in the case of any overdue
interest, Fee or other amount, the rate described in Section 2.09(b) applicable
to an ABR Revolving Loan plus 2.00% per annum, in each case from the date of
such nonpayment to (but excluding) the date on which such amount is paid in full
(after as well as before judgment).

                                      -56-

<PAGE>

                  (d)      Interest shall be payable in arrears on each Interest
Payment Date and on the Term B Loan Maturity Date and Revolving Credit Maturity
Date; provided that (i) interest accrued pursuant to paragraph (c) of this
Section shall be payable on demand, (ii) in the event of any repayment or
prepayment of any Loan, accrued interest on the principal amount repaid or
prepaid shall be payable on the date of such repayment or prepayment and (iii)
in the event of any conversion of any Eurocurrency Loan prior to the end of the
current Interest Period therefor, accrued interest on such Loan shall be payable
on the effective date of such conversion. Interest in respect of each Loan shall
accrue from and including the first day of an Interest Period to but excluding
the last day of such Interest Period. Interest on each Loan shall be paid in the
same currency as the currency in which the Loan is made.

                  SECTION 2.10. Computation of Interest. Each determination of
an interest rate by the Administrative Agent pursuant to any provision of this
Agreement shall be conclusive and binding on the Borrower and the Lenders in the
absence of manifest error.

                  SECTION 2.11. Fees. (a) The Borrower agrees to pay a
commitment fee (a "Commitment Fee") to each Revolving Lender, for which payment
will be made in arrears through the Administrative Agent on the last day of
March, June, September and December beginning after the Effective Date, and on
the Commitment Fee Termination Date (as defined below). The Commitment Fee due
to each Revolving Lender shall commence to accrue for a period commencing on the
Effective Date and shall cease to accrue on the date (the "Commitment Fee
Termination Date") that is the later of (i) the date on which the Revolving
Credit Commitment of such Revolving Lender shall be terminated as provided
herein and (ii) the first date after the end of the Revolving Credit Commitment
Period. The Commitment Fee accrued to each Revolving Lender shall equal 0.50%
per annum multiplied by such Lender's Commitment Fee Average Daily Amount (as
defined below) for the applicable quarter (or shorter period commencing on the
date of this Agreement and ending with such Lender's Commitment Fee Termination
Date). A Revolving Lender's "Commitment Fee Average Daily Amount" with respect
to a calculation period shall equal the average daily amount during such period
calculated using the daily amount of such Revolving Lender's Revolving Credit
Commitment less such Revolving Lender's Revolving Credit Exposure (excluding
clause (c) and, in the case of Revolving Lenders that are not also Foreign
Currency Lenders, clause (d) of the definition thereof for purposes of
determining the Commitment Fee Average Daily Amount only) for any applicable
days during such Revolving Lender's Revolving Credit Commitment Period. All
Commitment Fees shall be computed on the basis of the actual number of days
elapsed in a year of 360 days.

                  (b)      The Borrower agrees to pay (i) to the Administrative
Agent for the account of each Revolving Lender a participation fee with respect
to its participations in Letters of Credit, which shall accrue at a rate per
annum equal to the Applicable Rate for Eurocurrency Revolving Loans on the
average daily amount of such Lender's LC Exposure (excluding any portion thereof
attributable to unreimbursed LC Disbursements) during the period from and
including the Effective Date to but excluding the later of the date on which
such Revolving Lender's Revolving Credit Commitment terminates and the date on
which such Revolving Lender ceases to have any LC Exposure, and (ii) to the
Issuing Bank a fronting fee, which shall accrue at the rate of 0.25% per annum
on the average daily amount of the LC Exposure (excluding any portion

                                      -57-

<PAGE>

thereof attributable to unreimbursed LC Disbursements) during the period from
and including the Effective Date to but excluding the later of the date of
termination of the Revolving Credit Commitments and the date on which there
ceases to be any LC Exposure, as well as the Issuing Bank's standard fees with
respect to the issuance, amendment, renewal or extension of any Letter of Credit
or processing of drawings thereunder. Participation fees and fronting fees
(collectively, "LC Fees") accrued through and including the last day of March,
June, September and December of each calendar year during the Revolving Credit
Commitment Period shall be payable on the third Business Day following such last
day, commencing on the first such date to occur after the Effective Date;
provided that all such fees shall be payable on the date on which the Revolving
Credit Commitments terminate and any such fees accruing after the date on which
the Revolving Credit Commitments terminate shall be payable on demand. Any other
fees payable to the Issuing Bank pursuant to this paragraph shall be payable
within 10 days after demand therefor. All participation fees and fronting fees
shall be computed on the basis of a year of 360 days and shall be payable for
the actual number of days elapsed (including the first day but excluding the
last day).

                  (c)      The Borrower agrees to pay to the Administrative
Agent the annual administrative fee set forth in the Fee Letter (the "Agent
Fees").

                  (d)      All Fees shall be paid on the dates due, in
immediately available funds, to the Administrative Agent for distribution. Once
paid, none of the Fees shall be refundable.

                  SECTION 2.12. Termination, Reduction or Adjustment of
Commitments. (a) Unless previously terminated, (i) the Term B Commitments shall
terminate at 5:00 p.m., New York City time, on the Effective Date and (ii) the
Revolving Credit Commitments shall terminate on the Revolving Credit Maturity
Date.

                  (b)      The Borrower shall have the right, upon one Business
Day's notice to the Administrative Agent, to terminate or, from time to time,
reduce the amount of the Revolving Credit Commitments; provided that no such
termination or reduction of Revolving Credit Commitments shall be permitted if,
after giving effect thereto and to any repayments of the Loans made on the
effective date thereof, (i) the Aggregate Revolving Credit Exposure then
outstanding would exceed the Total Revolving Credit Commitment then in effect or
(ii) the Aggregate Foreign Currency Exposure then outstanding would exceed the
Maximum Foreign Currency Sublimit then in effect. Any such reduction shall be in
an amount equal to $5.0 million or a whole multiple of $1.0 million in excess
thereof and shall reduce permanently the Revolving Credit Commitments then in
effect.

                  (c)      If any prepayment of Term B Borrowings would
otherwise be required pursuant to Section 2.06 but cannot be made because there
are no Term B Borrowings outstanding, or because the amount of the required
prepayment exceeds the outstanding amount of Term B Borrowings, then, on the
date that such prepayment is required, the Revolving Credit Commitments shall be
permanently reduced by an aggregate amount equal to the amount of the required
prepayment, or the excess of such amount over the outstanding amount of Term B
Borrowings, as the case may be.

                                      -58-

<PAGE>

                  (d)      The Borrower shall pay to the Administrative Agent
for the account of the applicable Revolving Lenders, on each date of termination
or reduction of the Revolving Credit Commitments, the Commitment Fee on the
amount of the Revolving Credit Commitments so terminated or reduced accrued to
the date of such termination or reduction.

                  (e)      Each reduction in the Revolving Credit Commitments
shall reduce the Swingline Commitment of the Swingline Lender, and the Maximum
Foreign Currency Sublimit and the Foreign Currency Sublimit of each Foreign
Currency Lender, by an equal percentage.

                  SECTION 2.13. Inability to Determine Interest Rate;
Unavailability of Deposits; Inadequacy of Interest Rate. If prior to 11:00 a.m.,
London time, two Business Days before the first day of any Interest Period,
including an initial Interest Period, for a requested Eurocurrency Borrowing:

                  (i)      the Administrative Agent shall have determined in
         good faith (which determination shall be conclusive and binding upon
         the Borrower) that, by reason of circumstances affecting the relevant
         market generally, adequate and reasonable means do not exist for
         ascertaining the Adjusted LIBO Rate for the currency in which any
         Eurocurrency Loan is denominated or the currency specified in the
         Borrowing Request for such Eurocurrency Borrowing (the "Applicable
         Currency") for such Interest Period, or

                  (ii)     the Administrative Agent shall have received notice
         from a majority in interest of the Lenders of the applicable Class that
         the Adjusted LIBO Rate determined or to be determined for such Interest
         Period for such Applicable Currency will not adequately and fairly
         reflect the cost to such Lenders (as conclusively certified by such
         Lenders) of making or maintaining their affected Loans during such
         Interest Period,

then the Administrative Agent shall give telecopy or telephonic notice thereof
to the Borrower and the Lenders by 12:00 noon, New York City time, on the same
day. The Administrative Agent shall give telecopy or telephonic notice to the
Borrower and the Lenders as soon as practicable after the circumstances giving
rise to such notice no longer exist, and until such notice has been given, any
affected Eurocurrency Loans of the Applicable Currency shall not be (x)
converted or continued pursuant to Section 2.03 or (y) made pursuant to a
Borrowing Request, and shall be continued or made as ABR Loans (including the
requirement that all Foreign Currency Loans shall be replaced by Revolving
Dollar Loans pursuant to Section 2.04(a)(ii)), as the case may be.

                  SECTION 2.14. Pro Rata Treatment and Payments. (a) Each
reduction of the Revolving Credit Commitments of the Revolving Lenders shall be
made pro rata according to the amounts of such Revolving Lenders' Commitment
Percentages. Each payment (including each prepayment) by the Borrower on account
of principal of and interest on Loans which are ABR Loans shall be made pro rata
according to the respective outstanding principal amounts of such ABR Loans then
held by the Lenders of the applicable Class. Each payment (including each
prepayment) by the Borrower on account of principal of and interest on Loans
which are Eurocurrency Loans designated by the Borrower to be applied to a
particular Eurocurrency Borrowing shall be made pro rata according to the
respective outstanding principal amounts of such

                                      -59-

<PAGE>

Loans then held by the Lenders of the applicable Class. Each payment (including
each prepayment) by the Borrower on account of principal of and interest on
Swingline Loans and Foreign Currency Loans shall be made pro rata according to
the respective outstanding principal amounts of the Swingline Loans or Foreign
Currency Loans, as applicable, or participating interests therein, as the case
may be, then held by the relevant Lenders. All payments (including prepayments)
to be made by the Borrower hereunder, whether on account of principal, interest,
fees or otherwise, shall be made without setoff or counterclaim and shall be
made prior to 10:00 a.m., New York time, on the due date thereof to the
Administrative Agent, for the account of the Lenders of the applicable Class, at
the Administrative Agent's New York office specified in Section 10.01 in the
currency in which the applicable obligation is denominated (except as set forth
in Section 2.04) and in immediately available funds. The Administrative Agent
shall distribute such payments to the Lenders entitled thereto in the same
currency as received and promptly upon receipt in like funds as received. If any
payment hereunder (other than payments on Eurocurrency Loans) becomes due and
payable on a day other than a Business Day, such payment shall be extended to
the next succeeding Business Day, and, with respect to payments of principal,
interest thereon shall be payable at the then applicable rate during such
extension. If any payment on a Eurocurrency Loan becomes due and payable on a
day other than a Business Day, the maturity thereof shall be extended to the
next succeeding Business Day (and, with respect to payments of principal,
interest thereon shall be payable at the then applicable rate during such
extension) unless the result of such extension would be to extend such payment
into another calendar month, in which event such payment shall be made on the
immediately preceding Business Day.

                  (b)      Subject to Section 2.13, unless the Administrative
Agent shall have been notified in writing by any Lender prior to a Borrowing
that such Lender will not make the amount that would constitute its share of
such Borrowing available to the Administrative Agent, the Administrative Agent
may assume that such Lender is making such amount available to the
Administrative Agent, and the Administrative Agent may, in reliance upon such
assumption, make available to the Borrower a corresponding amount. If such
amount is not made available to the Administrative Agent by the required time on
the Borrowing Date therefor, such Lender shall pay to the Administrative Agent,
on demand, such amount with interest thereon at a rate equal to the daily
average Federal Funds Effective Rate for the period until such Lender makes such
amount immediately available to the Administrative Agent. A certificate of the
Administrative Agent submitted to any Lender with respect to any amounts owing
under this Section 2.14(b) shall be conclusive in the absence of manifest error.
If such Lender's share of such Borrowing is not made available to the
Administrative Agent by such Lender within three Business Days of such Borrowing
Date, the Administrative Agent shall also be entitled to recover such amount
with interest thereon at the rate per annum applicable to ABR Revolving Loans
hereunder, on demand, from the Borrower, but without prejudice to any right or
claim that the Borrower may have against such Lender.

                  (c)      If at any time insufficient funds are received by and
available to the Administrative Agent to pay fully all amounts of principal,
unreimbursed LC Disbursements, interest and fees then due hereunder, such funds
shall be applied (i) first, towards payment of interest and fees then due
hereunder, ratably among the parties entitled thereto in accordance with the

                                      -60-

<PAGE>

amounts of interest and fees then due to such parties, and (ii) second, towards
payment of principal and unreimbursed LC Disbursements then due hereunder,
ratably among the parties entitled thereto in accordance with the amounts of
principal and unreimbursed LC Disbursements then due to such parties.

                  SECTION 2.15. Illegality. Notwithstanding any other provision
herein, if the adoption of or any change in any Requirement of Law, or in the
interpretation or application thereof, shall make it unlawful for any Lender to
make or maintain Eurocurrency Loans as contemplated by this Agreement, (a) the
commitment of such Lender hereunder to make Eurocurrency Loans, continue
Eurocurrency Loans as such and convert ABR Loans to Eurocurrency Loans shall
forthwith be suspended until such time as the making or maintaining of
Eurocurrency Loans shall no longer be unlawful, and (b) such Lender's Loans then
outstanding as Eurocurrency Loans, if any, shall be converted automatically to
ABR Loans (including the requirement that all Foreign Currency Loans shall be
replaced by Revolving Dollar Loans pursuant to Section 2.04(a)(ii)) on the
respective last days of the then current Interest Periods with respect to such
Loans or within such earlier period as required by law.

                  SECTION 2.16. Requirements. (a) If at any time any Lender or
the Issuing Bank determines that the introduction of, or any change in or in the
interpretation of, any law, treaty or governmental rule, regulation or order
(other than any change by way of imposition or increase of reserve requirements
included in determining the Adjusted LIBO Rate) or the compliance by such Lender
or the Issuing Bank with any guideline, request or directive from any central
bank or other Governmental Authority (whether or not having the force of law),
shall have the effect of increasing the cost to such Lender or the Issuing Bank
for agreeing to make or making, funding or maintaining any Eurocurrency Loans or
participating in, issuing or maintaining any Letter of Credit, then the Borrower
shall from time to time, within five days of demand therefor by such Lender or
the Issuing Bank (with a copy of such demand to the Administrative Agent), pay
to the Administrative Agent for the account of such Lender or the Issuing Bank,
as applicable, additional amounts sufficient to compensate such Lender or the
Issuing Bank for such increased cost. A certificate as to the amount of such
increased cost, submitted to the Borrower and the Administrative Agent by such
Lender or the Issuing Bank, shall be conclusive and binding for all purposes,
absent manifest error. Such Lender or the Issuing Bank, as applicable, shall
promptly notify the Administrative Agent and the Borrower in writing of the
occurrence of any such event, such notice to state, in reasonable detail, the
reasons therefor and the additional amount required fully to compensate such
Lender or the Issuing Bank, as applicable, for such increased cost or reduced
amount. Such additional amounts shall be payable directly to such Lender or the
Issuing Bank, as applicable, within five days of the Borrower's receipt of such
notice, and such notice shall, in the absence of manifest error, be conclusive
and binding on the Borrower.

                  (b)      If any change in, or the introduction, adoption,
effectiveness, interpretation, reinterpretation or phase-in of, any law or
regulation, directive, guideline, decision or request (whether or not having the
force of law) of any court, central bank, regulator or other Governmental
Authority after the date hereof affects or would affect the amount of capital
required or expected to be maintained by any Lender or the Issuing Bank (or a
holding company control-

                                      -61-

<PAGE>

ling such Lender or the Issuing Bank) and such Lender or the Issuing Bank
determines (in its sole and absolute discretion) that the rate of return on its
capital (or the capital of its holding company, as the case may be) as a
consequence of its Revolving Credit Commitment or the Loans made by it or its
participations in Swingline Loans or Foreign Currency Loans or any issuance,
participation or maintenance of Letters of Credit is reduced to a level below
that which such Lender or the Issuing Bank (or its holding company) could have
achieved but for the occurrence of any such circumstance, then, in any such case
upon notice from time to time by such Lender or the Issuing Bank to the
Borrower, the Borrower shall immediately pay directly to such Lender or the
Issuing Bank, as the case may be, additional amounts sufficient to compensate
such Lender or the Issuing Bank (or its holding company) for such reduction in
rate of return. A statement of such Lender or the Issuing Bank as to any such
additional amount or amounts (including calculations thereof in reasonable
detail) shall, in the absence of manifest error, be conclusive and binding on
the Borrower. In determining such amount, such Lender or the Issuing Bank may
use any method of averaging and attribution that it (in its sole and absolute
discretion) shall deem applicable.

                  (c)      In the event that the Issuing Bank or any Lender
determines that any event or circumstance that will lead to a claim under this
Section 2.16 has occurred or will occur, the Issuing Bank or such Lender will
use its best efforts to so notify the Borrower; provided that any failure to
provide such notice shall in no way impair the rights of the Issuing Bank or
such Lender to demand and receive compensation under this Section 2.16, but
without prejudice to any claims of the Borrower for compensation for actual
damages sustained as a result of any failure to observe this undertaking.

                  SECTION 2.17. Taxes. (a) All payments by the Borrower of
principal of, and interest on, the Loans and all other amounts payable under the
Loan Documents and the Notes shall be made free and clear of and without
deduction for any present or future income, excise, stamp or franchise taxes and
other taxes, fees, duties, withholdings or other charges of any nature
whatsoever imposed by any taxing authority on the Administrative Agent, the
Issuing Bank, any Lender or any assignee of such Lender or the Issuing Bank, as
the case may be, or a Participant or a change in designation of the lending
office of a Lender or the Issuing Bank, as the case may be (a "Transferee"), but
excluding taxes imposed on or measured by the recipient's net income (or
franchise taxes imposed in lieu thereof) that are imposed by a taxing authority
in a jurisdiction in which the recipient is incorporated or organized or
maintains its principal place of business or a lending office (such non-excluded
items and any interest, penalties and related reasonable costs and expenses,
being called "Taxes"), unless required by applicable law, rule or regulation. In
the event that any withholding or deduction from any payment to be made by the
Borrower hereunder is required in respect of any Taxes pursuant to any
applicable law, rule or regulation, then the Borrower will:

                  (i)      pay directly to the relevant authority the full
         amount required to be so withheld or deducted;

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<PAGE>

                  (ii)     promptly forward to the Administrative Agent an
         official receipt or other documentation satisfactory to the
         Administrative Agent evidencing such payment to such authority; and

                  (iii)    pay to the Administrative Agent for its account or
         the account of a Lender, the Issuing Bank or the Transferee, as the
         case may be, such additional amount or amounts as are necessary to
         ensure that the net amount actually received by the Administrative
         Agent, such Lender, the Issuing Bank or such Transferee, as the case
         may be, will equal the full amount the Administrative Agent, such
         Lender, the Issuing Bank or such Transferee, as the case may be, would
         have received had no such withholding or deduction been required
         (including withholding or deduction in respect of additional amounts
         payable under this Section 2.17).

Moreover, if any Taxes are directly asserted, whether or not correctly asserted,
against the Administrative Agent, the Issuing Bank or any Lender or Transferee
with respect to any payment received by the Administrative Agent, the Issuing
Bank or such Lender or Transferee hereunder, the Borrower will promptly
indemnify each such party for the full amount of such Taxes.

                  (b)      If the Borrower fails to pay any Taxes when due to
the appropriate taxing authority or fails to remit to the Administrative Agent,
for its account or the account of the Issuing Bank, the respective Lenders or
Transferees, the required receipts or other required documentary evidence, the
Borrower shall indemnify the Administrative Agent, the Issuing Bank, the Lenders
and the Transferees for any incremental Taxes that may become payable by the
Administrative Agent, the Issuing Bank or any Lender or Transferee as a result
of any such failure. For purposes of this Section 2.17, a distribution hereunder
by the Administrative Agent to or for the account of the Issuing Bank or any
Lender or Transferee shall be deemed a payment by the Borrower.

                  (c)      Each Lender or Transferee that is organized under the
laws of a jurisdiction other than the United States of America or any state or
political subdivision thereof shall, on or prior to the Effective Date (in the
case of each Lender that is a party hereto on the Effective Date) or on or prior
to the date of any assignment, participation or change in the designated lending
office hereunder (in the case of a Transferee) and thereafter as reasonably
requested from time to time by the Borrower or the Administrative Agent, execute
and deliver, if legally able to do so, to the Borrower and the Administrative
Agent one or more (as the Borrower or the Administrative Agent may reasonably
request) United States Internal Revenue Service Forms W-8BEN or such other forms
or documents (or successor forms or documents) reasonably requested by the
Borrower, appropriately completed, as may be applicable to establish the extent,
if any, to which a payment to such Lender or Transferee is exempt from or
entitled to a reduced rate of withholding or deduction of Taxes imposed by the
United States. If a Lender or Transferee becomes aware of any fact that would
cause any form previously provided by such Lender or Transferee pursuant to this
paragraph (c) to become untrue in any material respect, or would prevent such
Lender or Transferee from providing a renewal form upon expiration of the form
previously provided, such Lender or Transferee shall promptly notify the
Borrower and the Administrative Agent.

                                      -63-

<PAGE>

                  (d)      The Borrower shall not be required to indemnify or to
pay any additional amounts to the Administrative Agent, the Issuing Bank or any
Lender or Transferee with respect to any Taxes imposed by the United States
pursuant to Section 2.17(a), Section 2.17(b) or this Section 2.17(d) to the
extent that (i) any obligation to withhold, deduct or pay amounts with respect
to such Tax existed on the date the Administrative Agent, the Issuing Bank or
such Lender or Transferee became a party to this Agreement or otherwise became a
Transferee (and, in such case, the Borrower may deduct and withhold such Tax
from payments to the Administrative Agent, the Issuing Bank, such Lender or
Transferee); provided that this clause (i) shall not apply to a party that is
not an original party to this Agreement (a "Subsequent Party") to the extent
that the Borrower's obligations with respect to such Subsequent Party on the
date such party becomes a Subsequent Party do not exceed the Borrower's
obligations with respect to the Subsequent Party's predecessor immediately prior
thereto, or (ii) any Lender or Transferee fails to comply in full with the
provisions of paragraph (c) above (and, in such case, the Borrower may deduct
and withhold all Taxes required by law as a result of such noncompliance from
payments to the Administrative Agent, the Issuing Bank or such Lender or
Transferee).

                  (e)      In addition, the Borrower shall pay all Other Taxes
imposed to the relevant Governmental Authority imposing such Other Taxes in
accordance with applicable law.

                  SECTION 2.18. Indemnity. In the event any Lender shall incur
any loss or expense (including any loss (other than lost profit) or expense
incurred by reason of the liquidation or reemployment of deposits or other funds
acquired by such Lender to make, continue or maintain any portion of the
principal amount of any Loan as, or to convert any portion of the principal
amount of any Loan into, a Eurocurrency Loan) as a result of any conversion of a
Eurocurrency Loan to an ABR Loan or repayment or prepayment of the principal
amount of any Eurocurrency Loan on a date other than the scheduled last day of
the Interest Period applicable thereto, whether pursuant to Section 2.03, 2.04,
2.06, 2.08, 2.13, 2.15, 2.16 or 2.21 or otherwise, or any failure to borrow or
convert any Eurocurrency Loan after notice thereof shall have been given
hereunder, whether by reason of any failure to satisfy a condition to such
Borrowing or otherwise, then, upon the written notice of such Lender to the
Borrower (with a copy to the Administrative Agent), the Borrower shall, within
five days of its receipt thereof, pay directly to such Lender such amount as
will (in the reasonable determination of such Lender) reimburse such Lender for
such loss or expense. Such written notice (which shall include calculations in
reasonable detail) shall, in the absence of manifest error, be conclusive and
binding on the Borrower.

                  SECTION 2.19. Change of Lending Office. Each Lender (or
Transferee) agrees that, upon the occurrence of any event giving rise to the
operation of Section 2.15, 2.16 or 2.17 with respect to such Lender (or
Transferee), it will, if requested by the Borrower, use commercially reasonable
efforts (subject to overall policy considerations of such Lender (or
Transferee)) to designate another lending office for any Loans affected by such
event with the object of avoiding the consequences of such event; provided that
such designation is made on terms that, in the sole judgment of such Lender,
cause such Lender and its respective lending offices to suffer no material
economic, legal or regulatory disadvantage; and provided, further, that nothing
in this Section 2.19 shall affect or postpone any of the Obligations of the
Borrower or the rights of any Lender (or Transferee) pursuant to Sections 2.15,
2.16 and 2.17.

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<PAGE>

                  SECTION 2.20. Sharing of Setoffs. Each Lender agrees that if
it shall, through the exercise of a right of banker's lien, setoff or
counterclaim against the Borrower, or pursuant to a secured claim under Section
506 of Title 11 of the United States Code or other security or interest arising
from, or in lieu of, such secured claim received by such Lender under any
applicable bankruptcy, insolvency or other similar law or otherwise, or by any
other means, obtain payment (voluntary or involuntary) in respect of any Loans
or participations in LC Disbursements which at the time shall be due and payable
as a result of which the unpaid principal portion of its Loans and
participations in LC Disbursements which at the time shall be due and payable
shall be proportionately less than the unpaid principal portion of such Loans
and participations in LC Disbursements of any other Lender, it shall be deemed
simultaneously to have purchased from such other Lender at face value, and shall
promptly pay to such other Lender the purchase price for, a participation in
such Loans and participations in LC Disbursements of such other Lender, so that
the aggregate unpaid principal amount of such Loans and participations in LC
Disbursements held by each Lender shall be in the same proportion to the
aggregate unpaid principal amount of all such Loans and participations in LC
Disbursements as prior to such exercise of banker's lien, setoff or counterclaim
or other event; provided, however, that if any such purchase or purchases or
adjustments shall be made pursuant to this Section and the payment giving rise
thereto shall thereafter be recovered, such purchase or purchases or adjustments
shall be rescinded to the extent of such recovery and the purchase price or
prices or adjustments restored without interest. The Borrower expressly consents
to the foregoing arrangements and agrees that any Lender holding a participation
in a Loan or an LC Disbursement deemed to have been so purchased may exercise
any and all rights of banker's lien, setoff or counterclaim with respect to any
and all moneys owing by the Borrower to such Lender by reason thereof as fully
as if such Lender were a direct creditor directly to the Borrower in the amount
of such participation.

                  SECTION 2.21. Assignment of Commitments Under Certain
Circumstances. In the event that (a) any Lender shall have delivered a notice or
certificate pursuant to Section 2.16, or the Borrower shall be required to make
additional payments to any Lender under Section 2.17 (each, an "Increased Cost
Lender"), or (b) in connection with any proposed amendment, modification,
termination, waiver or consent with respect to any of the provisions hereof that
fall within the proviso to the first sentence of Section 10.08(b), the consent
of all Lenders would have been obtained but for one or more Lenders representing
no more than 25% of the aggregate amount of Term B Loans outstanding and the
Revolving Credit Commitments (or after the Revolving Credit Maturity Date, the
Revolving Credit Exposure) failure to consent (each such Lender, a
"Non-Consenting Lender"); then, with respect to each such Increased Cost Lender
or Non-Consenting Lender (the "Terminated Lender"), the Borrower shall have the
right, but not the obligation, at its own expense, upon notice to such
Terminated Lender and the Administrative Agent, to replace such Terminated
Lender with an assignee (in accordance with and subject to the restrictions
contained in Section 10.04) approved by the Administrative Agent, the Issuing
Bank, the Swingline Lender and Foreign Currency Lender (which approval shall not
be unreasonably withheld), and such Terminated Lender hereby agrees to transfer
and assign without recourse (in accordance with and subject to the restrictions
contained in Section 10.04) all its interests, rights and obligations under this
Agreement to such assignee; provided, however, that no Terminated Lender shall
be obligated to make any such assignment unless (i) such assignment

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<PAGE>

shall not conflict with any law or any rule, regulation or order of any
Governmental Authority and (ii) such assignee or the Borrower shall pay to the
affected Terminated Lender in immediately available funds on the date of such
assignment the principal of and interest accrued to the date of payment on the
Loans made by such Terminated Lender and participations in LC Disbursements,
Swingline Loans and Foreign Currency Loans held by such Terminated Lender and
all commitment fees and other fees owed to such Terminated Lender hereunder and
all other amounts accrued for such Terminated Lender's account or owed to it
hereunder (including, without limitation, any Commitment Fees).

                                   ARTICLE III

                         REPRESENTATIONS AND WARRANTIES

                  In order to induce the Lenders and the Administrative Agent to
enter into this Agreement and to extend credit hereunder and under the other
Loan Documents, the Loan Parties, jointly and severally, make the
representations and warranties set forth in this Article III on the Effective
Date (after giving effect to the Transactions) and upon the occurrence of each
Credit Event thereafter:

                  SECTION 3.01. Organization, etc. Each Loan Party (a) is a
corporation or other form of legal entity, and each of its Subsidiaries is a
corporation, partnership or other form of legal entity, duly organized and
validly existing and in good standing under the laws of the jurisdiction of its
incorporation or organization, as the case may be, (b) has the requisite
corporate or other power and authority to carry on its business as now
conducted, (c) is duly qualified to do business and is in good standing as a
foreign corporation or foreign partnership (or comparable foreign qualification,
if applicable, in the case of any other form of legal entity), as the case may
be, in each jurisdiction where the nature of its business requires such
qualification, except where the failure to so qualify will not result in a
Material Adverse Effect, and (d) has full power and authority and holds all
requisite material governmental licenses, permits and other approvals to enter
into and perform its obligations under this Agreement and each other Loan
Document to which it is a party and to own or hold under lease its Property and
to conduct its business substantially as currently conducted by it.

                  SECTION 3.02. Due Authorization, Non-Contravention, etc.
Assuming the execution and delivery of this Agreement by each of the other
parties hereto, the execution, delivery and performance by each Loan Party of
this Agreement and each other Loan Document to which it is a party, the
borrowing of the Loans, the use of the proceeds thereof and the issuance of the
Letters of Credit hereunder are within each Loan Party's corporate, partnership
or comparable powers, as the case may be, have been duly authorized by all
necessary corporate, partnership or comparable and, if required, stockholder
action, as the case may be, and do not

                  (a)      contravene the Organic Documents of any Loan Party or
         any of its respective Subsidiaries;

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<PAGE>

                  (b)      subject to the receipt of government approvals set
         forth on Schedule 3.03, contravene any law or governmental regulation
         or court decree or order binding on or affecting any Loan Party or any
         of its respective Subsidiaries;

                  (c)      except as set forth on Schedule 3.02, violate or
         result in a default under any indenture, agreement or other instrument
         binding upon any Loan Party or any of its respective Subsidiaries; or

                  (d)      result in, or require the creation or imposition of,
         any Lien on any assets of any Loan Party or any of its respective
         Subsidiaries that would have or could reasonably be expected to have a
         Material Adverse Effect, except Liens created under the Loan Documents.

                  SECTION 3.03. Government Approval, Regulation, etc. Except as
set forth on Schedule 3.03, no consent, authorization or approval or other
action by, and no notice to or filing with, any Governmental Authority or
regulatory body or other Person is required for the due execution, delivery or
performance by the Borrower or any other Loan Party of this Agreement or any
other Loan Document, the borrowing of the Loans, the use of the proceeds thereof
and the issuance of Letters of Credit hereunder, nor for the consummation of the
Transactions, except such as have been obtained or made and are in full force
and effect and except filings necessary to perfect Liens under the Security
Documents. No Loan Party or any of its respective Subsidiaries is an "investment
company" within the meaning of the Investment Company Act of 1940, as amended,
or a "holding company", or a "subsidiary company" of a "holding company", or an
"affiliate" of a "holding company" or of a "subsidiary company" of a "holding
company", within the meaning of the Public Utility Holding Company Act of 1935,
as amended.

                  SECTION 3.04. Validity, etc. This Agreement and each other
Loan Document to which any Loan Party is to be a party has been duly executed
and delivered by such Loan Party and constitutes, assuming the due execution and
delivery of this Agreement and such other Loan Document by each of the other
parties thereto, the legal, valid and binding obligation of such Loan Party
enforceable in accordance with its respective terms, subject to the effect of
bankruptcy, insolvency, reorganization, moratorium or similar laws affecting the
enforceability of creditors' rights generally and to general principles of
equity.

                  SECTION 3.05. Activities of Parent Guarantors and Acquisition
Corp. As of the Effective Date, each of the Parent Guarantors and Acquisition
Corp. has had no operations, assets or liabilities.

                  SECTION 3.06. Representations and Warranties in the Merger
Agreement. (a) Each of the representations and warranties set forth in Article
III of the Merger Agreement remains true and correct (unless expressly stated to
relate to an earlier date, in which case such representations and warranties
were true and correct as of such earlier date).

                  (b)      Subject to the qualifications set forth in Section
7.3(a) of the Merger Agreement, each of the representations and warranties set
forth in Article IV of the Merger

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<PAGE>

Agreement remains true and correct (unless expressly stated to relate to an
earlier date, in which case such representations and warranties were true and
correct as of such earlier date).

                  SECTION 3.07. Financial Information. (a) The consolidated
balance sheets of the Borrower and its Subsidiaries as of December 31, 2001 and
2002, reported on by PricewaterhouseCoopers LLP in the case of the balance sheet
dated as of December 31, 2002, independent public accountants, and as of June
30, 2003, certified by the Borrower's chief financial officer, and the related
consolidated statements of earnings and cash flow of the Borrower and its
Subsidiaries for the three years ended December 31, 2002, copies of which have
been furnished to the Administrative Agent and each Lender, have been prepared
in accordance with GAAP consistently applied (except as may be indicated therein
or in the notes thereto), and present fairly in all material respects the
consolidated financial condition of the Borrower and its Subsidiaries as of the
dates thereof and the results of their operations and changes in financial
position for the periods then ended.

                  (b)      Except as disclosed in the financial statements
referred to above or the notes thereto or in the Information Memorandum, none of
the Borrower or its Subsidiaries or the Parent Guarantors has, as of the
Effective Date, any material (i) Indebtedness, (ii) contingent liabilities,
(iii) long-term commitments or (iv) unrealized losses.

                  SECTION 3.08. [Reserved].

                  SECTION 3.09. No Material Adverse Change. Since December 31,
2002, no event or circumstance (other than to the extent the Lenders have been
reasonably apprised of such event or occurrence pursuant to Schedule 3.09 as in
effect on the Effective Date) has occurred that has had, or could reasonably be
expected to have, a Material Adverse Effect.

                  SECTION 3.10. Litigation. Except as set forth on Schedule
3.10, there is no pending or, to the knowledge of the Loan Parties, threatened
litigation, action or proceeding (including, without limitation, any existing or
new litigation relating to the Merger) affecting any Loan Party or any of its
Subsidiaries, or any of their respective operations or properties, or the
ability of the parties to consummate the transactions contemplated hereby, which
has had or could reasonably be expected to have a Material Adverse Effect or
which purports to affect the legality, validity or enforceability of this
Agreement or any other Loan Document or the transactions contemplated hereby or
thereby.

                  SECTION 3.11. Compliance with Laws and Agreements. None of the
Borrower or any of its Subsidiaries has violated, is in violation of or has been
given written notice of any violation of any laws (other than Environmental
Laws, which are the subject of Section 3.16), regulations and orders of any
Governmental Authority applicable to it or its property and all indentures,
agreements and other instruments binding upon it or its property, except for any
violations which could not reasonably be expected to result in a Material
Adverse Effect. No Default or Event of Default has occurred and is continuing.

                  SECTION 3.12. Subsidiaries. Schedule 6.04 (a) sets forth the
name of (i) each Subsidiary and the direct or indirect ownership interest of the
Parent Guarantors and the Bor-

                                      -68-
<PAGE>

rower therein and (ii) Investments of the Parent Guarantors, the Borrower and
each Subsidiary in Persons other than Subsidiaries and (b) identifies each
Subsidiary that is a Subsidiary Loan Party, in each case as of the Effective
Date.

                  SECTION 3.13. Ownership of Properties. (a) Each of the
Borrower and its Subsidiaries has good and legal fee simple title to (or other
similar legal title in jurisdictions outside the United States of America), or
valid leasehold interests in, or easements or other limited property interests
in, or is licensed to use, all its material properties and assets (including all
Mortgaged Properties), except for defects in title (or such other rights as
referenced above, as applicable) that do not materially interfere with its
ability to conduct its business as currently conducted or to utilize such
properties and assets for their intended purposes and except where the failure
to have such title (or such other rights as referenced above, as applicable) in
the aggregate could not reasonably be expected to have a Material Adverse
Effect. All such material properties and assets are free and clear of Liens,
other than Permitted Liens.

                  (b)      As of the Effective Date, Schedule 3.13(b) contains
and will contain a true and complete list of each parcel of Real Property (i)
owned in fee by any Loan Party as of the date hereof and describes the type of
interest therein held by such Loan Party and (ii) leased, subleased or otherwise
occupied by any Loan Party, as lessee, as of the date hereof and describes the
type of interest therein held by such Loan Party and whether such lease,
sublease or other instrument requires the consent of the landlord thereunder or
other parties thereto to the Transactions.

                  (c)      Each of the Borrower and its Subsidiaries has
complied with all obligations under all leases to which it is a party, except
where the failure to comply would not have a Material Adverse Effect, and all
such leases are in full force and effect, except leases in respect of which the
failure to be in full force and effect could not reasonably be expected to have
a Material Adverse Effect. Each of the Borrower and its Subsidiaries enjoys
peaceful and undisturbed possession under all such leases, other than leases in
respect of which the failure to enjoy peaceful and undisturbed possession could
not reasonably be expected to, individually or in the aggregate, result in a
Material Adverse Effect.

                  (d)      Each of the Borrower and its Subsidiaries owns,
possesses, is licensed or otherwise has the right to use, or could obtain
ownership or possession of, on terms not materially adverse to it, all patents,
trademarks, service marks, trade names, copyrights, licenses and rights with
respect thereto necessary for the present conduct of its business, without any
known conflict with the rights of others, except where such conflicts could not,
individually or in the aggregate, reasonably be expected to have a Material
Adverse Effect.

                  (e)      As of the Effective Date, no Loan Party or any of its
respective Subsidiaries has received any written notice of any actual pending or
threatened condemnation proceeding affecting any of the Mortgaged Properties or
any sale or disposition thereof in lieu of condemnation that remains unresolved
as of the Effective Date.

                                      -69-
<PAGE>

                  (f)      Neither the Borrower nor any of its Subsidiaries is
obligated on the Effective Date under any right of first refusal, option or
other contractual right to sell, assign or otherwise dispose of any Mortgaged
Property or any interest therein.

                  SECTION 3.14. Taxes. Each of the Borrower and its Subsidiaries
has timely filed all federal, foreign and all other material income tax returns
and reports required by law to have been filed by it and has paid all taxes and
governmental charges due, except any such taxes or charges which are being
diligently contested in good faith by appropriate proceedings and for which
adequate reserves in accordance with GAAP shall have been set aside on its
books; provided that any such contest of taxes or charges with respect to
Collateral shall satisfy the Contested Collateral Lien Conditions.

                  SECTION 3.15. Pension and Welfare Plans. (a) No ERISA Event
has occurred or is reasonably expected to occur which could reasonably be
expected to have a Material Adverse Effect or give rise to a Lien on the assets
of any Loan Party or a Subsidiary. The Borrower and its Subsidiaries and their
ERISA Affiliates are in compliance in all respects with the presently applicable
provisions of ERISA and the Code with respect to each Plan except for failures
to so comply which could not reasonably be expected to have a Material Adverse
Effect. No condition exists or event or transaction has occurred with respect to
any Plan which reasonably might result in the incurrence by the Borrower or any
of its Subsidiaries or any ERISA Affiliate of any liability, fine or penalty
which could reasonably be expected to have a Material Adverse Effect. Neither
the Borrower nor any of its Subsidiaries has any contingent liability with
respect to post-retirement benefits provided by the Borrower or any of its
Subsidiaries under a Welfare Plan, other than (i) liability for continuation
coverage described in Part 6 of Subtitle B of Title I of ERISA, (ii) liabilities
under employment agreements existing on the Effective Date and (iii) liabilities
that, individually or in the aggregate, could not reasonably be expected to have
a Material Adverse Effect.

                  (b) Except as could not reasonably be expected to have a
Material Adverse Effect or as set forth on Schedule 3.15(b), (i) each Foreign
Plan has been maintained in compliance with its terms and with the requirements
of any and all applicable laws, statutes, rules, regulations and orders and has
been maintained, where required, in good standing with applicable regulatory
authorities, and (ii) neither the Borrower nor any of its Subsidiaries has
incurred any obligation in connection with the termination of or withdrawal from
any Foreign Plan.

                  SECTION 3.16. Environmental Warranties. Except as set forth on
Schedule 3.16:

                  (a)      All facilities and property owned, leased or operated
         by the Borrower or any of its Subsidiaries, and all operations
         conducted thereon, are in compliance with all Environmental Laws,
         except for such noncompliance that, individually or in the aggregate,
         could not reasonably be expected to have a Material Adverse Effect.

                                      -70-

<PAGE>

                  (b)      There are no pending or threatened (in writing):

                           (i)      Environmental Claims received by the
                  Borrower or any of its Subsidiaries, or

                           (ii)     written claims, complaints, notices or
                  inquiries received by the Borrower or any of its Subsidiaries
                  regarding Environmental Liability,

         in each case which, individually or in the aggregate, could reasonably
         be expected to have a Material Adverse Effect.

                  (c)      There have been no Releases of Hazardous Materials
         at, on, under or from any property now or, to any Loan Party's
         knowledge, previously owned, leased or operated by the Borrower or any
         of its Subsidiaries that, individually or in the aggregate, have had or
         could reasonably be expected to have a Material Adverse Effect.

                  (d)      The Borrower and its Subsidiaries have been issued
         and are in compliance with all Environmental Permits necessary for
         their operations, facilities and businesses and each is in full force
         and effect, except for such Environmental Permits which, if not so
         obtained or as to which the Borrower and its Subsidiaries are not in
         compliance, or are not in effect, individually or in the aggregate,
         could not reasonably be expected to have a Material Adverse Effect.

                  (e)      No property now or, to any Loan Party's knowledge,
         previously owned, leased or operated by the Borrower or any of its
         Subsidiaries is listed or proposed (with respect to owned property
         only) for listing on the CERCLIS or on any similar state list of sites
         requiring investigation or clean-up, or on the National Priorities List
         pursuant to CERCLA.

                  (f)      There are no underground storage tanks, active or
         abandoned, including petroleum storage tanks, surface impoundments or
         disposal areas, on or under any property now or, to any Loan Party's
         knowledge (without independent investigation or inquiry), previously
         owned or leased by the Borrower or any of its Subsidiaries which,
         singly or in the aggregate, could reasonably be expected to have a
         Material Adverse Effect.

                  (g)      Neither the Borrower nor any of its Subsidiaries has
         transported or arranged for the transportation of any Hazardous
         Material to any location which is listed or proposed for listing on the
         National Priorities List pursuant to CERCLA, on the CERCLIS or on any
         similar state list or which is the subject of federal, state or local
         enforcement actions or other investigations which would reasonably be
         expected to lead to any Environmental Claim against the Borrower or
         such Subsidiary that could reasonably be expected to have a Material
         Adverse Effect.

                  (h)      No liens have been recorded pursuant to any
         Environmental Law with respect to any property or other assets
         currently owned or leased by the Borrower or its Subsidiaries.

                                      -71-

<PAGE>

                  (i)      Neither the Borrower nor any of its Subsidiaries is
         currently conducting any Remedial Action pursuant to any Environmental
         Law, nor has any of the Loan Parties or any of their respective
         Subsidiaries assumed by contract, agreement or operation of law any
         obligation under Environmental Law, the cost of which, singly or in the
         aggregate, could reasonably be expected to have a Material Adverse
         Effect.

                  (j)      There are no polychlorinated biphenyls or friable
         asbestos present at any property owned, leased or operated by the
         Borrower or any of its Subsidiaries, which, singly or in the aggregate,
         could reasonably be expected to have a Material Adverse Effect.

                  SECTION 3.17. Regulations U and X. The Loans, the use of the
proceeds thereof, this Agreement and the transactions contemplated hereby will
not result in a violation of or be inconsistent with any provision of Regulation
U or X.

                  SECTION 3.18. Disclosure; Accuracy of Information; Pro Forma
Balance Sheets and Projected Financial Statements. (a) The Loan Parties have
disclosed to the Lenders all agreements, instruments and corporate or other
restrictions to which they or any of their Subsidiaries is subject, and all
other matters known to any of them that, individually or in the aggregate, could
reasonably be expected to have a Material Adverse Effect. Neither this Agreement
nor the factual statements in any other document, certificate or statement
furnished to the Administrative Agent or any Lender by or on behalf of any Loan
Party in connection herewith (including, without limitation, the Information
Memorandum) contains any untrue statement of a material fact or omits to state
any material fact necessary in order to make the statements contained herein and
therein not misleading, in light of the circumstances under which they were
made; provided that to the extent this or any such document, certificate or
statement (including without limitation the Information Memorandum) was based
upon or constitutes a forecast, projection or internal summary analysis, the
Loan Parties represent only that they acted in good faith and utilized
reasonable assumptions and due care in the preparation of such document,
certificate or statement for the purposes intended.

                  (b)      Not less than one week prior to the Effective Date,
the Borrower shall have furnished to the Lenders the pro forma consolidated
balance sheet as of June 30, 2003, prepared giving effect to the Transactions as
if the Transactions had occurred on such date. Such pro forma consolidated
balance sheet (i) was prepared in good faith based on the same assumptions used
to prepare the pro forma financial statements included in the Information
Memorandum, (ii) accurately reflects all adjustments necessary to give effect to
the Transactions and (iii) presents fairly the pro forma financial position of
the Borrower and its consolidated Subsidiaries as of the Effective Date, as if
the Transactions had occurred on such date.

                  (c)      Not less than one week prior to the Effective Date,
the Borrower shall have furnished to the Lenders pro forma consolidated income
statement projections for the Borrower and its Subsidiaries, pro forma
consolidated balance sheet projections for the Borrower and its Subsidiaries and
pro forma consolidated cash flow projections for the Borrower and its
Subsidiaries, all for the Fiscal Years ending 2004 through 2008, inclusive (the
"Projected Financial Statements"), which give effect to the Transactions and all
Indebtedness and Liens incurred

                                      -72-

<PAGE>

or created in connection with the Transactions. The assumptions made in
preparing the Projected Financial Statements are reasonable as of the date of
such projections and all material assumptions with respect to the Projected
Financial Statements are set forth therein. The Projected Financial Statements
present a good faith estimate of the consolidated financial information
contained therein at the date thereof, it being recognized by the Administrative
Agent and the Lenders, however, that projections as to future events are not to
be viewed as facts and that the actual results during the period or periods
covered by the projections probably will differ from the projected results and
that the difference may be material.

                  SECTION 3.19. Insurance. As of the Effective Date, set forth
on Schedule 3.19 is a summary of all insurance policies maintained by the
Borrower and each of its Subsidiaries with financially sound and responsible
insurers (a) with respect to its properties material to the business of the
Borrower and its Subsidiaries against such casualties and contingencies and of
such types and in such amounts as are customary in the case of similar
businesses operating in the same or similar locations, and (b) required to be
maintained pursuant to the Security Documents.

                  SECTION 3.20. Labor Matters. Except as could not reasonably be
expected to have a Material Adverse Effect, (a) there are no strikes, lockouts
or slowdowns against the Borrower or any Subsidiary pending or, to the knowledge
of any Loan Party, threatened; (b) the hours worked by and payments made to
employees of the Borrower and its Subsidiaries have not been in violation of the
Fair Labor Standards Act or any other applicable Federal, state, local or
foreign law dealing with such matters; and (c) all payments due from the
Borrower or any Subsidiary, or for which any claim may be made against the
Borrower or any Subsidiary, on account of wages and employee health and welfare
insurance and other benefits, have been paid or accrued as a liability on the
books of the Borrower or such Subsidiary.

                  SECTION 3.21. Solvency. Immediately following the making of
each Loan and after giving effect to the application of the proceeds of such
Loans, and in the case of the Subsidiary Loan Parties, after giving effect to
the terms of the Guarantee Agreement, (a) the fair value of the assets of each
Loan Party, at a fair valuation, will exceed its debts and liabilities,
subordinated, contingent or otherwise; (b) the present fair saleable value of
the property of each Loan Party will be greater than the amount that will be
required to pay the probable liability of its debts and other liabilities,
subordinated, contingent or otherwise, as such debts and other liabilities
become absolute and matured; (c) each Loan Party will be able to pay its debts
and liabilities, subordinated, contingent or otherwise, as such debts and
liabilities become absolute and matured; and (d) each Loan Party will not have
unreasonably small capital with which to conduct the business in which it is
engaged as such business is now conducted and is proposed to be conducted.

                  SECTION 3.22. Securities. The common stock of each of the
Parent Guarantors' and the Borrower's Subsidiaries has been validly issued and
fully paid and is nonassessable and free of preemptive rights that have not been
waived. The Equity Interests of each Subsidiary held, directly or indirectly, by
the Borrower are owned, directly or indirectly, by the Borrower and, after the
Effective Date, by the Parent Guarantors, free and clear of all Liens. There are
not,

                                      -73-

<PAGE>

as of the Effective Date, any existing options, warrants, calls, subscriptions,
convertible or exchangeable securities, rights, agreements, commitments or
arrangements for any Person to acquire any common stock of the Borrower or its
Subsidiaries or any other securities convertible into, exchangeable for or
evidencing the right to subscribe for any such common stock, except as disclosed
in the financial statements delivered pursuant to Sections 5.01(a) and (b) or
otherwise disclosed to the Lenders prior to the Effective Date.

                  SECTION 3.23. Indebtedness Outstanding. Set forth on Schedule
6.01(a)(iii) hereto is a list and description of (a) all Indebtedness (without
giving effect to clause (k) in the definition of "Indebtedness") of the Borrower
and its Subsidiaries (other than the Loans) outstanding on the Effective Date
and (b) all Indebtedness of the Borrower and its Subsidiaries that will be
repaid, defeased, transferred or otherwise terminated on or prior to the
Effective Date. Schedule 6.02 hereto is a list and description of all Liens
(other than Liens permitted by Sections 6.02(iii), (v), (ix), (x), (xii) and
(xiii)) of the Borrower and its Subsidiaries outstanding on the Effective Date.

                  SECTION 3.24. Security Documents. (a) The Pledge Agreement and
each Non-U.S. Pledge Agreement is effective to create in favor of the Collateral
Agent for its benefit and the benefit of the Secured Parties, a legal, valid and
enforceable security interest in the Collateral (as defined in the Pledge
Agreement or Non-U.S. Pledge Agreement, as applicable) and, when such Collateral
is delivered to the Collateral Agent, the Pledge Agreement shall constitute a
fully perfected Lien on, and security interest in, all right, title and interest
of the pledgor thereunder in such Collateral.

                  (b)      (i) The Security Agreement is effective to create in
favor of the Collateral Agent, for its benefit and the benefit of the Secured
Parties, a legal, valid and enforceable security interest in the Collateral (as
defined in the Security Agreement) and (ii) when (x) financing statements in
appropriate form are filed in the offices specified on Schedule 7 to the
Perfection Certificate and (y) upon the taking of possession or control by the
Collateral Agent of any such Collateral in which a security interest may be
perfected only by possession or control (which possession or control shall be
given to the Collateral Agent to the extent possession or control by the
Collateral Agent is required by the Security Agreement), the Security Agreement
shall constitute a fully perfected Lien on, and security interest in, all right,
title and interest of the grantors thereunder in such Collateral (other than the
Intellectual Property (as defined in the Security Agreement)) to the extent such
Lien and security interest can be perfected by the filing of a financing
statement pursuant to the UCC or by possession or control by the Collateral
Agent, in each case prior and superior in right to any other Person, other than
with respect to Permitted Liens.

                  (c)      When the filings in clause (b)(ii)(x) above are made
and when the Security Agreement (or a summary thereof) is filed in the United
States Patent and Trademark Office and the United States Copyright Office, the
Security Agreement shall constitute a fully perfected Lien on, and security
interest in, all right, title and interest of the Loan Parties in the
Intellectual Property (as defined in the Security Agreement) in which a security
interest may be perfected by filing, recording or registering a security
agreement, financing statement or analogous document

                                      -74-

<PAGE>

in the United States Patent and Trademark Office or the United States Copyright
Office, as applicable (it being understood that subsequent recordings in the
United States Patent and Trademark Office and the United States Copyright Office
may be necessary to perfect a Lien on registered trademarks, trademark
applications and copyrights acquired by the Loan Parties after the Effective
Date), in each case prior and superior in right to any other Person other than
with respect to Permitted Liens.

                  (d)      Each Mortgage executed and delivered as of the
Effective Date is, or, to the extent any Mortgage is duly executed and delivered
thereafter by the relevant Loan Party, such Mortgage will be, effective to
create (subject to Permitted Encumbrances (as defined in each Mortgage)) in
favor of the Collateral Agent, for its benefit and the benefit of the Secured
Parties, a legal, valid and enforceable Lien on and security interest in all of
the Loan Parties' right, title and interest in and to the Mortgaged Properties
thereunder and the proceeds thereof, if and when the Mortgages are filed in the
offices specified on Schedule 3.24(d), no other recordings of filings will be
necessary to give constructive notice to third Persons of, and to otherwise
establish of record the Lien on, and security interest in, all right, title and
interest of the Loan Parties in such Mortgaged Properties and the proceeds
thereof, in each case prior and superior in right to any other Person, other
than with respect to the rights of Persons pursuant to Permitted Encumbrances.

                  SECTION 3.25. Anti-Terrorism Laws. (a) None of the Loan
Parties or, to the knowledge of any of the Loan Parties, any of their Affiliates
is in violation of any laws relating to terrorism or money laundering
("Anti-Terrorism Laws"), including Executive Order No. 13224 on Terrorist
Financing, effective September 24, 2001 (for the purposes of this Section 3.25
only, the "Executive Order"), and the Uniting and Strengthening America by
Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of
2001, Public Law 107-56.

                  (b)      No Loan Party or, to the knowledge of any of the Loan
Parties, any of their Affiliates or their respective brokers or other agents
acting or benefiting in any capacity in connection with the Loans is any of the
following:

                  (i)      a Person or entity that is listed in the annex to, or
         is otherwise subject to the provisions of, the Executive Order;

                  (ii)     a Person or entity owned or controlled by, or acting
         for or on behalf of, any Person or entity that is listed in the annex
         to, or is otherwise subject to the provisions of, the Executive Order;

                  (iii)    a Person or entity with which any Lender is
         prohibited from dealing or otherwise engaging in any transaction by any
         Anti-Terrorism Law;

                  (iv)     a Person or entity that commits, threatens or
         conspires to commit or supports "terrorism" as defined in the Executive
         Order; or

                                      -75-

<PAGE>

                  (v)      a Person or entity that is named as a "specially
         designated national and blocked person" on the most current list
         published by the U.S. Treasury Department Office of Foreign Assets
         Control at its official website or any replacement website or other
         replacement official publication of such list.

                  (c)      No Loan Party or, to the knowledge of any Loan Party,
any of its brokers or other agents acting in any capacity in connection with the
Loans (i) conducts any business or engages in making or receiving any
contribution of funds, goods or services to or for the benefit of any Person
described in clause (b) above, (ii) deals in, or otherwise engages in any
transaction relating to, any property or interests in property blocked pursuant
to the Executive Order, or (iii) engages in or conspires to engage in any
transaction that evades or avoids, or has the purpose of evading or avoiding, or
attempts to violate, any of the prohibitions set forth in any Anti-Terrorism
Law.

                                   ARTICLE IV

                                   CONDITIONS

                  SECTION 4.01. Effective Date. The obligations of the Lenders
to make Loans and of the Issuing Bank to issue Letters of Credit hereunder shall
not become effective until the date on which each of the following conditions is
satisfied (or waived in accordance with Section 10.08) and subject to
satisfaction of the conditions set forth in Section 4.02:

                  (a)      The Administrative Agent (or its counsel) shall have
         received from each party hereto either (i) a counterpart of this
         Agreement signed on behalf of such party or (ii) written evidence
         satisfactory to the Administrative Agent (which may include telecopy
         transmission of a signed signature page of this Agreement) that such
         party has signed a counterpart of this Agreement.

                  (b)      The Administrative Agent shall have received
         counterparts of the Guarantee Agreement signed on behalf of each
         Domestic Subsidiary.

                  (c)      The Administrative Agent shall have received, on
         behalf of itself and the Lenders, favorable written opinions of each of
         (i) Morgan Lewis & Bockius LLP, New York counsel for the Loan Parties,
         substantially in the form of Exhibit K-1, (ii) Smith, Anderson, Blount,
         Dorsett, Mitchell & Jernigan, L.L.P., counsel for the Loan Parties,
         substantially in the form of Exhibit K-2, (iii) local counsel to the
         Loan Parties and to each of the Non-U.S. Subsidiaries in each of the
         Non-U.S. Jurisdictions (in each case unless, and to the extent,
         otherwise agreed by the Administrative Agent) referred to in Schedule
         4.01(c), in each case reasonably satisfactory to the Administrative
         Agent, which opinions shall (x) be addressed to the Administrative
         Agent and the Lenders and be dated the Effective Date, (y) cover the
         perfection and priority of the security interests granted in respect of
         the Equity Interests of Persons organized in such Non-U.S.
         Jurisdiction, and such other matters incident to the transactions
         contemplated herein as the Administrative Agent may reasonably request
         and (z) be in form, scope and substance reasonably satisfactory to the
         Administrative Agent, and (iv) local counsel to the Loan Parties as
         speci-

                                      -76-

<PAGE>

         fied on Schedule 4.01(c) in the forms of Exhibit L and reasonably
         satisfactory to the Agents, which opinions (x) shall be addressed to
         the Administrative Agent and each of the Lenders and be dated the
         Effective Date, (y) shall cover the enforceability of the respective
         Mortgage and perfection of the Liens and security interests granted
         pursuant to the relevant Security Documents and such other matters
         incident to the transactions contemplated herein as the Administrative
         Agent may reasonably request and (z) shall be in form and substance
         reasonably satisfactory to the Administrative Agent.

                  (d)      The Administrative Agent shall have received a
         certificate, dated the Effective Date and signed by a Financial Officer
         of the Borrower, confirming compliance with the conditions precedent
         set forth in Sections 4.01 and 4.02(b) and (c) substantially in the
         form of Exhibit G.

                  (e)      The Administrative Agent shall have received from
         each Loan Party a certificate, dated the Effective Date, signed by the
         Secretary of such Loan Party and attested to by an Authorized Officer
         of such Loan Party together with copies of the certificate of
         incorporation, by-laws or equivalent organizational documents of such
         Loan Party, and the resolutions of such Loan Party authorizing the
         Transactions on or prior to the Effective Date.

                  (f)      The Administrative Agent shall have received such
         documents and certificates as the Administrative Agent or its counsel
         may reasonably request relating to the organization, existence and good
         standing of each Loan Party, the authorization of the Transactions and
         any other legal matters relating to the Loan Parties, the Loan
         Documents or the Transactions, all in form and substance reasonably
         satisfactory to the Administrative Agent and its counsel.

                  (g)      [Reserved]

                  (h)      All documents executed or submitted in connection
         with this Agreement, the Borrowings hereunder and the other Loan
         Documents shall be reasonably satisfactory to the Lenders.

                  (i)      The issuance of the Subordinated Notes by the
         Borrower shall have been consummated on the Effective Date and shall
         have terms and conditions consistent with and as set forth in the
         Offering Memorandum dated September 25, 2003. On the Effective Date,
         (x) the Administrative Agent shall have received true and correct
         copies of all Subordinated Notes Documents, certified as such by an
         appropriate officer of the Borrower, (y) all such Subordinated Notes
         Documents, and all terms and conditions thereof, shall be in form and
         substance reasonably satisfactory to the Lenders and (z) all such
         Subordinated Notes Documents shall be in full force and effect. Each of
         the conditions precedent to the consummation of the issuance of the
         Subordinated Notes as set forth in the Subordinated Notes Documents
         shall have been satisfied in all material respects and not waived
         except with the consent of the Administrative Agent.

                                      -77-

<PAGE>

                  (j)      There shall not have occurred any event or
         circumstance (other than to the extent the Lenders have been reasonably
         apprised of such event or occurrence pursuant to Schedule 3.09 as in
         effect on the Effective Date) since December 31, 2002 that,
         individually or in the aggregate with such other events or
         circumstances, has, or could reasonably be expected to have, a Material
         Adverse Effect.

                  (k)      The Borrower shall have delivered to the Lenders (a)
         audited consolidated balance sheets for the two Fiscal Years ended
         before the Effective Date and related statements of income,
         stockholders' equity and cash flows of the Borrower for the three
         Fiscal Years ended before the Effective Date and (b) to the extent
         available, unaudited consolidated balance sheets and related statements
         of income, stockholders' equity and cash flows of the Borrower for each
         completed Fiscal Quarter since the date of such audited financial
         statements (and, to the extent available, for each completed month
         since the last such quarter), which audited and unaudited financial
         statements (i) shall be in form and scope satisfactory to the Lenders
         and (ii) shall not be materially inconsistent with the financial
         statements previously provided to the Lenders.

                  (l)      Except as set forth on Schedule 3.10, no litigation
         or administrative proceeding or development in any litigation or
         administrative proceeding (including, without limitation, existing or
         new litigation relating to the Merger) by any entity (private or
         governmental) shall be pending or, to the knowledge of the Borrower,
         threatened (i) with respect to the Transactions or any documentation
         executed in connection therewith (including any Loan Document) or the
         transactions contemplated thereby or (ii) which has had, or could
         reasonably be expected to have, a Material Adverse Effect.

                  (m)      The Borrower shall have obtained a senior secured
         debt rating in respect of the Loans from each of S&P and Moody's, and
         the Loans shall continue to be rated on the Effective Date.

                  (n)      All corporate and legal proceedings and all
         instruments and agreements in connection with the transactions
         contemplated by this Agreement and the other Loan Documents to occur on
         or prior to the Effective Date shall be in form and substance
         reasonably satisfactory to the Administrative Agent, and the
         Administrative Agent shall have received all information and copies of
         all documents and papers, including records of corporate proceedings,
         governmental approvals, good standing certificates and bring down
         telegrams or facsimiles, if any, which the Administrative Agent
         reasonably may have requested in connection therewith, such documents
         and papers where appropriate to be certified by proper corporate or
         governmental authorities.

                  (o)      The Lenders shall have received a certificate of the
         chief financial officer of the Borrower in form of Exhibit M and
         reasonably satisfactory to the Administrative Agent, confirming the
         solvency of each of the Loan Parties on a consolidated basis after
         giving effect to the Transactions.

                  (p)      Each of the OEP Equity Investment and the DG Equity
         Rollover shall have been consummated, and all documentation relating to
         the OEP Equity Investment

                                      -78-

<PAGE>

         and the DG Equity Rollover shall be in form and substance satisfactory
         to the Administrative Agent.

                  (q)      The Administrative Agent shall be satisfied that the
         Borrower shall have cash in an amount not less than $579,222,000
         available to fund in part the merger consideration under the Merger
         Agreement.

                  (r)      The merger of Acquisition Corp. with and into the
         Borrower with the Borrower surviving shall have been consummated in
         accordance with the Merger Agreement and all other related documents.
         On the Effective Date, (x) the Administrative Agent shall have received
         true and correct copies of all Merger Documents, certified as such by
         an appropriate officer of the Borrower, (y) all changes to the Merger
         Documents, and all changes to the terms and conditions thereof, shall
         be in form and substance reasonably satisfactory to the Administrative
         Agent and (z) all Merger Documents shall be in full force and effect.
         Each of the conditions precedent to the consummation of the Merger as
         set forth in the Merger Documents shall have been satisfied in all
         material respects and not waived, consented to or approved except with
         the consent of the Administrative Agent, to the reasonable satisfaction
         of the Administrative Agent.

                  (s)      After giving effect to the Transactions, none of the
         Parent Guarantors or the Borrower or their respective consolidated
         Subsidiaries shall have outstanding any Indebtedness other than (a) the
         Loans and other extensions of credit under this Agreement, (b) the
         Subordinated Notes and (c) Indebtedness specified on Schedule
         6.01(a)(iii) to remain outstanding after the Effective Date or as
         otherwise permitted to be incurred (and such Indebtedness shall be
         deemed to have been incurred as of the Effective Date) under Section
         6.01(a).

                  (t)      All requisite material governmental authorities and
         third parties shall have approved or consented to the Transactions to
         the extent required, all applicable appeal periods shall have expired
         and there shall be no judicial or regulatory action by a governmental
         agency, actual or threatened, that could reasonably be expected to
         restrain, prevent or impose materially burdensome conditions on the
         Transactions.

                  (u)      The Administrative Agent shall have received all Fees
         payable to the Administrative Agent or any Lender on or prior to the
         Effective Date under the Fee Letter and all other amounts due and
         payable pursuant to the Loan Documents on or prior to the Effective
         Date, including reimbursement or payment of all reasonable
         out-of-pocket expenses (including reasonable fees, charges and
         disbursements of Cahill Gordon & Reindel LLP and domestic and foreign
         local counsel) required to be reimbursed or paid by the Borrower
         hereunder or under any other Loan Document.

                  (v)      The Lenders shall be satisfied that the amount and
         nature of any environmental and employee health and safety liabilities
         and exposures to which the Parent Guarantors, the Borrower and their
         consolidated Subsidiaries may be subject after giving effect to the
         Transactions could not be reasonably expected to have a Material
         Adverse Effect.

                                      -79-

<PAGE>

                  (w)      The Collateral Agent shall have received (i)
         counterparts of the Pledge Agreement signed by each Loan Party and
         covering pledges of (A) 100% of the Equity Interests held directly by
         the Parent in the Intermediate Parent, by the Intermediate Parent in
         the Borrower, by the Borrower in all of its Domestic Subsidiaries and
         each Subsidiary Loan Party in its domestic Subsidiaries and (B) 65% of
         the voting Equity Interests and 100% of the non-voting Equity Interests
         held directly by any Loan Party in any Non-U.S. Subsidiary, (ii)
         counterparts of the Non-U.S. Pledge Agreements signed by the applicable
         Loan Party and covering pledges of 65% of the voting Equity Interests
         and 100% of the non-voting Equity Interests of the "first tier"
         Non-U.S. Subsidiaries of the Borrower or the applicable Subsidiary Loan
         Party identified on Schedule 4.01(w) and (iii) promissory notes
         evidencing all Indebtedness for liabilities over $500,000 owed to any
         Loan Party by the Borrower or any Subsidiary as of the Effective Date,
         in each case, together with undated stock powers or other instruments
         of transfer, endorsed in blank.

                  (x)      The Collateral Agent shall have received counterparts
         of the Security Agreement signed by each Loan Party together with the
         following in form and substance satisfactory to the Collateral Agent:

                           (A)      certificates of insurance required under the
                  Security Documents;

                           (B)      appropriate financing statements or
                  comparable documents authorized by (and executed by, to the
                  extent applicable) the appropriate entities in proper form for
                  filing under the provisions of the UCC and applicable domestic
                  or local laws, rules or regulations in each of the offices
                  where such filing is necessary or appropriate, in the
                  Collateral Agent's sole discretion, to grant to the Collateral
                  Agent a perfected first priority Lien on such Collateral,
                  superior and prior to the rights of all third persons other
                  than the holders of Permitted Liens;

                           (C)      UCC, judgment and tax lien, bankruptcy and
                  pending lawsuit search reports listing all effective financing
                  statements or comparable documents which name any applicable
                  Loan Party as debtor and which are filed in those
                  jurisdictions in which, any Loan Party is organized, any of
                  such Collateral is located and the jurisdictions in which any
                  applicable Loan Party's principal place of business is located
                  in the United States, together with copies of such existing
                  financing statements, none of which shall encumber such
                  Collateral covered or intended or purported to be covered by
                  the Security Documents other than Permitted Liens;

                           (D)      evidence of the preparation for recording or
                  filing, as applicable, of all recordings and filings of each
                  such Security Document, including, without limitation, with
                  the United States Patent and Trademark Office and the United
                  States Copyright Office, and delivery and recordation, if
                  necessary, of such other security and other documents,
                  including, without limitation, UCC-3 termination statements
                  with respect to UCC filings that do not constitute Permitted
                  Liens, as may be necessary or, in the opinion of the
                  Collateral Agent, desirable to perfect the Liens created, or
                  purported or intended to be created, by such Security
                  Documents;

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                           (E)      with respect to leased Mortgaged Property,
                  if Inventory (as defined in the Security Agreement), Equipment
                  (as defined in the Security Agreement) or other personal
                  property of any Loan Party or its Subsidiaries is maintained
                  on such premises, the Borrower shall use its commercially
                  reasonable efforts to deliver a Landlord Subordination
                  substantially in the form of Exhibit P attached hereto with
                  respect thereto;

                           (F)      evidence that all other actions reasonably
                  necessary or, in the opinion of the Collateral Agent,
                  desirable to perfect the security interest created by the
                  Security Documents have been taken; and

                           (G)      a completed Perfection Certificate dated the
                  Effective Date and signed by an executive officer or Financial
                  Officer of the Borrower, together with all attachments
                  contemplated thereby, including the results of a search of the
                  UCC (or equivalent) filings made with respect to the Loan
                  Parties in the jurisdictions contemplated by the Perfection
                  Certificate and copies of the financing statements (or similar
                  documents) disclosed by such search and evidence reasonably
                  satisfactory to the Administrative Agent that the Liens
                  indicated by such financing statements (or similar documents)
                  are Permitted Liens or have been released.

                  (y)      The Collateral Agent shall have received the
         following documents and instruments:

                           (A)      Mortgages encumbering each Mortgaged
                  Property in which the applicable Loan Party holds a fee
                  ownership or leasehold interest (as indicated on Schedule
                  4.01(y)(A) hereto) in favor of the Collateral Agent, for its
                  benefit and the benefit of the Secured Parties, duly executed
                  and acknowledged by the applicable Loan Party, and otherwise
                  in form for recording in the recording office where each such
                  Mortgaged Property is situated, together with such
                  certificates, affidavits, questionnaires or returns as shall
                  be legally required in connection with the recording or filing
                  thereof to create a lien under applicable law, and such UCC-1
                  financing statements and other similar statements as are
                  contemplated by the counsel opinions described in Section
                  4.01(c)(iv) in respect of such Mortgage, all of which shall be
                  in form and substance reasonably satisfactory to the
                  Collateral Agent, and any other instruments necessary to grant
                  a mortgage lien under the laws of any applicable jurisdiction,
                  if any, which Mortgage and financing statements and other
                  instruments shall when recorded be effective to create a Lien
                  on such Mortgaged Property subject to no other Liens other
                  than the Permitted Encumbrances (as defined in such Mortgage);

                           (B)      with respect to each Mortgaged Property,
                  such consents, approvals, amendments, supplements, estoppels,
                  tenant subordination agreements or other instruments, in form
                  reasonably acceptable to the Collateral Agent, as necessary or
                  required to consummate the transactions contemplated hereby or
                  as shall reasonably be deemed necessary by the Collateral
                  Agent in order for the owner or holder of the fee or leasehold
                  interest constituting such Mortgaged Property to

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                  grant the Lien contemplated by the Mortgage with respect to
                  such Mortgaged Property;

                           (C)      with respect to each Mortgage indicated on
                  Schedule 4.01(y)(A), a policy (or commitment to issue a
                  policy) of title insurance insuring (or committing to insure)
                  the Lien of such Mortgage as a valid first mortgage Lien on
                  the real property or leasehold interest, as the case may be,
                  and fixtures described therein in an amount not less than the
                  amount set forth on Schedule 4.01(y)(C) (110% of the fair
                  market value thereof), which policies (or commitments) shall,
                  to the extent the same are available within each particular
                  state in which the applicable Mortgaged Property is located,
                  (w) be issued by the Title Company, (x) include such
                  reinsurance arrangements (with provisions for direct access)
                  as shall be reasonably acceptable to the Collateral Agent, (y)
                  contain a "tie-in" or "cluster" endorsement (if available
                  under applicable law) (i.e., policies which insure against
                  losses regardless of location or allocated value of the
                  insured property up to a stated maximum coverage amount) and
                  have been supplemented by such endorsements as shall be
                  reasonably requested by the Collateral Agent (including,
                  without limitation, endorsements, to the extent available in
                  each jurisdiction at commercially reasonably rates, on matters
                  relating to usury, first loss, last dollar, zoning,
                  contiguity, variable rate, revolving credit, doing business,
                  access, survey, address and so-called comprehensive coverage
                  over covenants and restrictions) and (z) contain only such
                  exceptions to title as shall be agreed to by the Collateral
                  Agent on or prior to the Effective Date with respect to such
                  Mortgaged Property, in each case, subject to Permitted
                  Encumbrances as defined in the Mortgage encumbering each such
                  Mortgaged Property;

                           (D)      with respect to each Mortgaged Property,
                  policies or certificates of insurance as required by the
                  Mortgage relating thereto, which policies or certificates
                  shall comply with the insurance requirements contained in such
                  Mortgage;

                           (E)      with respect to each Mortgaged Property
                  indicated on Schedule 4.01(y)(A), a Survey in form reasonably
                  acceptable to the Collateral Agent (it is intended and agreed
                  that a Survey will be required only for each Mortgaged
                  Property owned in fee and whole building leases);

                           (F)      with respect to each Mortgaged Property,
                  such affidavits, certificates, information (including
                  financial data) and instruments of indemnification (including,
                  without limitation, a so-called "gap" indemnification) as
                  shall be reasonably required to induce the Title Company to
                  issue the policy or policies (or commitment) and endorsements
                  contemplated in subparagraph (C) above;

                           (G)      evidence reasonably acceptable to the
                  Collateral Agent of payment by the appropriate Loan Party or
                  Subsidiary thereof of all applicable title insurance premiums,
                  search and examination charges, survey costs and related
                  charges, mortgage recording taxes, fees, charges, costs and
                  expenses required for the re-

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<PAGE>

                  cording of the Mortgages and issuance of the title insurance
                  policies referred to in subparagraph (C) above;

                           (H)      with respect to each Real Property or
                  Mortgaged Property, copies of all leases or other agreements
                  relating to possessory interests to which any Loan Party or
                  Subsidiary thereof is a party. To the extent any of the
                  foregoing in which any Loan Party is a landlord or sublandlord
                  affect any Mortgaged Property, such agreement shall be
                  subordinate to the Mortgage to be recorded against such
                  Mortgaged Property and otherwise acceptable to the Collateral
                  Agent; and

                           (I)      with respect to each Mortgaged Property
                  indicated on Schedule 4.01(y)(A), an Officers' Certificate
                  substantially in the form of Exhibit O attached hereto.

                  (z)      The Administrative Agent shall have received
         subordination agreements (to the extent legally permitted) in form and
         substance satisfactory to it covering all intercompany notes or other
         obligations owed by a Loan Party to a Subsidiary of the Borrower that
         is not a Loan Party.

                  (aa)     The Borrower shall have delivered to the
         Collateral Agent certificates of insurance with respect to all existing
         insurance coverage maintained by the Borrower and the Subsidiary Loan
         Parties which certificates shall comply with Section 5.04 hereof and
         shall provide evidence that the insurance coverage required by Section
         5.04 and the Security Documents is in effect in form and substance
         satisfactory to the Collateral Agent.

                  SECTION 4.02. Conditions to Each Credit Event. The agreement
of each Lender to make any Loan (excluding continuations and conversions of
Loans) and of the Issuing Bank to issue, amend, renew or extend any Letter of
Credit (such event being called a "Credit Event") requested to be made by it on
any date is subject to the satisfaction of the following conditions:

                  (a)      The Administrative Agent shall have received a notice
         of such Credit Event as required by Section 2.02, 2.04, 2.05 or 2.07,
         as applicable (or such notice shall have been deemed given in
         accordance with Section 2.04(b)).

                  (b)      The representations and warranties set forth in
         Article III hereof and in the other Loan Documents shall be true and
         correct with the same effect as if then made (unless expressly stated
         to relate to an earlier date, in which case such representations and
         warranties shall be true and correct as of such earlier date).

                  (c)      At the time of and immediately after such Credit
         Event, no Default or Event of Default shall have occurred and be
         continuing.

Each Credit Event shall be deemed to constitute a representation and warranty by
the Borrower on the date of such Credit Event, as to the matters specified in
paragraphs (b) and (c) of this Section 4.02.

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                                    ARTICLE V

                              AFFIRMATIVE COVENANTS

                  Each Loan Party hereby covenants and agrees with the Lenders
that on or after the Effective Date and until the Commitments have expired or
terminated and the principal of and interest on each Loan and all fees and other
amounts payable hereunder or under any other Loan Document have been paid in
full and all Letters of Credit have expired or terminated and all LC
Disbursements shall have been reimbursed:

                  SECTION 5.01. Financial Information, Reports, Notices, etc.
The Borrower will furnish, or will cause to be furnished, to each Lender and the
Administrative Agent copies of the following financial statements, reports,
notices and information:

                  (a)      as soon as available and in any event within 50 days
         (or five days after such shorter period for the filing of the
         Borrower's Form 10-Q as may be required by the SEC) after the end of
         each of the first three Fiscal Quarters of each Fiscal Year of the
         Borrower, a consolidated balance sheet of the Borrower and its
         Restricted Subsidiaries and similar consolidated balance sheet of the
         Borrower and its Subsidiaries as of the end of such Fiscal Quarter and
         consolidated statements of earnings and cash flow of the Borrower and
         its Restricted Subsidiaries and similar consolidated statements of
         earnings and cash flow of the Borrower and its Subsidiaries for such
         Fiscal Quarter and for the same period in the prior Fiscal Year and for
         the period commencing at the end of the previous Fiscal Year and ending
         with the end of such Fiscal Quarter, certified by a Financial Officer
         of the Borrower;

                  (b)      as soon as available and in any event within 95 days
         (or five days after such shorter period as may be required for the
         filing of the Borrower's Form 10-K by the SEC) after the end of each
         Fiscal Year of the Borrower, a copy of the annual audit report for such
         Fiscal Year for the Borrower and its Subsidiaries, including therein a
         consolidated balance sheet of the Borrower and its Restricted
         Subsidiaries and a similar consolidated balance sheet of the Borrower
         and its Subsidiaries as of the end of such Fiscal Year and consolidated
         statements of earnings and cash flow of the Borrower and its Restricted
         Subsidiaries and similar consolidated statements of earnings and cash
         flow of the Borrower and its Subsidiaries for such Fiscal Year, in each
         case certified (without any Impermissible Qualification) in a manner
         acceptable to the Administrative Agent by PricewaterhouseCoopers LLP or
         other independent public accountants reasonably acceptable to the
         Administrative Agent, together with a certificate from a Financial
         Officer of the Borrower (a "Compliance Certificate") containing a
         computation in reasonable detail of, and showing compliance with, each
         of the financial ratios and restrictions contained in Sections 6.13
         through 6.16, inclusive, and to the effect that, in making the
         examination necessary for the signing of such certificate, such
         Financial Officer has not become aware of any Default or Event of
         Default that has occurred and is continuing, or, if such Financial
         Officer has become aware of such Default or Event of Default,
         describing such Default or Event of Default and the steps, if any,
         being taken to cure it, and concurrently

                                      -84-

<PAGE>

         with the delivery of the foregoing financial statements, a certificate
         of the accounting firm that reported on such financial statements
         stating whether they obtained knowledge during the course of their
         examination of such financial statements of any Default or Event of
         Default (which certificate may be limited to the extent required by
         accounting rules or guidelines);

                  (c)      as soon as available and in any event within 30 days
         after the end of each of the first two months of each Fiscal Quarter of
         the Borrower, a consolidated balance sheet of the Borrower and its
         Restricted Subsidiaries and a similar balance sheet of the Borrower and
         its Subsidiaries as of the end of such month and consolidated
         statements of earnings and cash flow of the Borrower and its Restricted
         Subsidiaries and similar consolidated statements of earnings of the
         Borrower and its Subsidiaries for such month and for the same period in
         the prior Fiscal Year and for the period commencing at the end of the
         previous Fiscal Year and ending with the end of such month, certified
         by a Financial Officer of the Borrower;

                  (d)      as soon as available and in any event within 50 days
         (or five days after such shorter period as may be required for the
         filing of the Borrower's Form 10-Q by the SEC) after the end of each
         Fiscal Quarter, a Compliance Certificate containing a computation in
         reasonable detail of, and showing compliance with, each of the
         financial ratios and restrictions contained in Sections 6.13 through
         6.16, inclusive, and to the effect that, in making the examination
         necessary for the signing of such certificate, such Financial Officers
         have not become aware of any Default or Event of Default that has
         occurred and is continuing, or, if such Financial Officers have become
         aware of such Default or Event of Default, describing such Default or
         Event of Default and the steps, if any, being taken to cure it;

                  (e)      no later than January 31 of each Fiscal Year of the
         Borrower, a detailed consolidated budget by Fiscal Quarter for such
         Fiscal Year (including a projected consolidated balance sheet and
         related statements of projected operations and cash flow as of the end
         of and for each Fiscal Quarter during such Fiscal Year) and the
         succeeding Fiscal Years through the Term B Loan Maturity Date
         (including a projected consolidated balance sheet and related
         statements of projected operations and cash flow as of the end of each
         such Fiscal Year) having the same level of detail as the projections
         referred to in Section 3.18(c) and, promptly when available, any
         significant revisions of such budgets;

                  (f)      promptly upon receipt thereof, copies of all reports
         submitted to the Borrower by independent certified public accountants
         in connection with each annual, interim or special audit of the books
         of the Borrower or any of its Subsidiaries made by such accountants,
         including any management letters submitted by such accountants to
         management in connection with their annual audit;

                  (g)      as soon as possible and in any event within three
         Business Days after a Responsible Officer of the Borrower becomes aware
         of the occurrence of any Default or Event of Default, a statement of
         such Responsible Officer setting forth details of such

                                      -85-

<PAGE>

         Default or Event of Default and the action which the Borrower has taken
         and proposes to take with respect thereto;

                  (h)      as soon as possible and in any event within five
         Business Days after a Responsible Officer becoming aware of (i) the
         occurrence of any adverse development with respect to any litigation,
         action or proceeding described in Section 3.10 that, individually or in
         the aggregate, could reasonably be expected to have a Material Adverse
         Effect or (ii) the commencement of any litigation, action or proceeding
         of the type described in Section 3.10 that could reasonably be expected
         to have a Material Adverse Effect or that purports to affect the
         legality, validity or enforceability of this Agreement or any other
         Loan Document or the transactions contemplated hereby or thereby,
         notice thereof and copies of all documentation relating thereto;

                  (i)      promptly after the sending or filing thereof, copies
         of all reports which the Borrower sends to any of its security holders,
         and all reports, registration statements (other than on Form S-8 or any
         successor form) or other materials (including affidavits with respect
         to reports) which the Borrower or any of its Subsidiaries or any of
         their officers files with the SEC or any national securities exchange;

                  (j)      promptly upon becoming aware of the taking of any
         specific actions by the Borrower or any other Person to terminate any
         Pension Plan (other than a termination pursuant to Section 4041(b) of
         ERISA which can be completed without the Borrower or any ERISA
         Affiliate having to provide more than $1.0 million in addition to the
         normal contribution required for the plan year in which termination
         occurs to make such Pension Plan sufficient), or the occurrence of an
         ERISA Event which could result in a Lien on the assets of any Loan
         Party or a Subsidiary or in the incurrence by a Loan Party of any
         liability, fine or penalty which could reasonably be expected to have a
         Material Adverse Effect, or any increase in the contingent liability of
         a Loan Party with respect to any post-retirement Welfare Plan benefit
         if the increase in such contingent liability which could reasonably be
         expected to have a Material Adverse Effect, notice thereof and copies
         of all documentation relating thereto;

                  (k)      upon request by the Administrative Agent, copies of:
         (i) each Schedule B (Actuarial Information) to the annual report (Form
         5500 Series) filed by any Loan Party or a Subsidiary thereof with the
         Internal Revenue Service with respect to each Pension Plan; (ii) the
         most recent actuarial valuation report for each Pension Plan sponsored,
         maintained or contributed to by any Loan Party or a Subsidiary thereof;
         (iii) all notices received by any Loan Party or a Subsidiary thereof
         from a Multiemployer Plan sponsor or any governmental agency concerning
         an ERISA Event; and (iv) such other documents or governmental reports
         or filings relating to any Plan as the Administrative Agent shall
         reasonably request;

                  (l)      as soon as possible, after a Responsible Officer of
         the Borrower becomes aware of any notice of any other development that
         could reasonably be expected to have a Material Adverse Effect;

                                      -86-

<PAGE>

                  (m)      on the 10th day of each month (or, if not a Business
         Day, the Business Day immediately following such day) a report setting
         forth the amount of aggregate unused availability on such date of
         Revolving Credit Commitments;

                  (n)      simultaneously with the delivery of financial
         statements pursuant to Sections 5.01(a) and (b), certifications by the
         chief executive officer and the chief financial officer or others to
         the extent required to be filed under the Exchange Act, the
         Sarbanes-Oxley Act of 2002, as amended, and/or the rules and
         regulations of the SEC, without any exceptions or qualifications; and

                  (o)      such other information respecting the condition or
         operations, financial or otherwise, of the Borrower or any of its
         Subsidiaries as any Lender through the Administrative Agent may from
         time to time reasonably request.

                  SECTION 5.02. Compliance with Laws, etc. The Loan Parties
will, and will cause each of their Subsidiaries to, comply in all respects with
all applicable laws, rules, regulations and orders, except where such
noncompliance, individually or in the aggregate, could not reasonably be
expected to have a Material Adverse Effect, such compliance to include, subject
to the foregoing (without limitation):

                  (a)      the maintenance and preservation of their and their
         Subsidiaries' existence and their qualification as a foreign
         corporation or partnership (or comparable foreign qualification, if
         applicable, in the case of any other form of legal entity), and

                  (b)      the payment, before the same become delinquent, of
         all taxes, assessments and governmental charges imposed upon them or
         upon their property except as provided in Section 5.09.

                  (c)      Quintiles Ireland (Finance) Limited (the "Irish
         Company") effecting the financial assistance whitewash procedure set
         out in Section 60(2)-(11) of the Companies Act, 1963 of Ireland prior
         to the Irish Company guaranteeing or granting any security for any
         obligation hereunder or making any payment (whether envisaged by this
         Agreement or otherwise) which is to be used directly or indirectly to
         repay any facilities advanced hereunder which were or are to be used to
         acquire shares in the Irish Company or any shares of any holding
         company (as defined by reference to Section 155 of such Act) of the
         Irish Company.

                  SECTION 5.03. Maintenance of Properties. Each Loan Party and
each of its respective Restricted Subsidiaries will maintain, preserve, protect
and keep its material properties and assets in good repair, working order and
condition (reasonable wear and tear excepted), and make necessary and proper
repairs, renewals and replacements so that its business carried on in connection
therewith may be properly conducted at all times; provided that nothing in this
Section 5.03 shall prevent any Loan Party from discontinuing the operation,
maintenance or preservation of any of its properties or any of those of its
Restricted Subsidiaries if such discontinuance is, in the reasonable commercial
judgment of such Loan Party, desirable in the conduct of its or their business
and does not in the aggregate have a Material Adverse Effect.

                                      -87-

<PAGE>

                  SECTION 5.04. Insurance. The Loan Parties will and will cause
each of their respective Subsidiaries to maintain or cause to be maintained with
financially sound and responsible insurers (a) insurance with respect to their
properties material to the business of the Loan Parties and their respective
Subsidiaries against such casualties and contingencies and of such types and in
such amounts with such deductibles as is customary in the case of similar
businesses operating in the same or similar locations and (b) all insurance
required to be maintained pursuant to the Security Documents, and will, upon
request of the Administrative Agent, furnish to each Lender at reasonable
intervals a certificate of an Authorized Officer of the Borrower setting forth
the nature and extent of all insurance maintained by the Loan Parties and their
respective Subsidiaries in accordance with this Section. Each such insurance
policy shall provide that (i) it may not be cancelled or otherwise terminated
without at least thirty (30) days' prior written notice to the Collateral Agent
(and to the extent any such policy is cancelled or renewed, the Borrower shall
deliver a copy of the renewal or replacement policy (or other evidence thereof)
to the Administrative Agent and the Collateral Agent, or insurance certificate
with respect thereto, together with evidence satisfactory to the Administrative
Agent and Collateral Agent of the payment of the premium therefor); (ii) the
Collateral Agent is permitted to pay any premium therefor within thirty (30)
days after receipt of any notice stating that such premium has not been paid
when due; (iii) all losses thereunder shall be payable notwithstanding any act
or negligence of any Loan Party or any of its Subsidiaries or its agents or
employees which otherwise might have resulted in a forfeiture of all or a part
of such insurance payments; (iv) to the extent such insurance policy constitutes
property insurance, all losses payable thereunder in an amount in excess of $2.0
million (other than losses related to claims in respect of business
interruption) shall be payable to the Collateral Agent, as an additional insured
and as loss payee, pursuant to a standard non-contributory New York mortgagee
endorsement and shall be in an amount at least sufficient to prevent coinsurance
liability; provided that the Collateral Agent, as loss payee pursuant to the
foregoing, shall not agree to the adjustment of any claim without the consent of
the Borrower (such consent not to be unreasonably withheld or delayed); and (v)
with respect to liability insurance, the Collateral Agent shall be named as an
additional insured; provided, in the event that Borrower's or any Loan Parties'
compliance with this Agreement with respect to the insurance requirements of
this Section 5.04 will result in a default under any lease encumbered by a
Mortgagee, Mortgagor need only comply with the provisions of this Agreement with
respect to any such lease to the greatest extent possible without causing a
default under any such lease. Notwithstanding the inclusion in each insurance
policy of the provision described in clause (ii) of the immediately preceding
sentence, in the event any Loan Party gives the Collateral Agent written notice
that it does not intend to pay any premium relating to any insurance policy on
which the Collateral Agent is named or to be named as an additional insured when
due, the Collateral Agent shall not exercise its right to pay such premium so
long as such Loan Party delivers to the Collateral Agent a replacement insurance
policy or insurance certificate evidencing that such replacement policy or
certificate provides the same insurance coverage required under this Section
5.04 as the policy being replaced by such Loan Party with no lapse in such
coverage.

                  SECTION 5.05. Books and Records; Visitation Rights. Each Loan
Party will, and will cause each of its respective Subsidiaries to, keep books
and records which accurately reflect its business affairs in all material
respects and material transactions and permit the Administrative Agent and each
Lender or any of their respective representatives, at reasonable times

                                      -88-

<PAGE>

and intervals, to visit all of its offices, to discuss its financial matters
with its officers and independent public accountant and, upon the reasonable
request of the Administrative Agent or a Lender, to examine (and, at the expense
of the Borrower, photocopy extracts from) any of its books or other corporate or
partnership records.

                  SECTION 5.06. Environmental Covenant. Each Loan Party will,
and will cause each of its respective Subsidiaries to:

                  (a)      use and operate all of its facilities and properties
         in compliance with all Environmental Laws except for such noncompliance
         which, singly or in the aggregate, would not reasonably be expected to
         have a Material Adverse Effect, keep all Environmental Permits in
         effect and remain in compliance therewith and handle all Hazardous
         Materials in compliance with all applicable Environmental Laws, except
         for any noncompliance that would not reasonably be expected to have a
         Material Adverse Effect;

                  (b)      promptly notify the Administrative Agent and provide
         copies of all written inquiries, claims, complaints or notices from any
         Person relating to the environmental condition of its facilities and
         properties or compliance with or liability under any Environmental Law
         which could reasonably be expected to have a Material Adverse Effect,
         and promptly cure and have dismissed with prejudice or contest in good
         faith any actions and proceedings relating thereto;

                  (c)      in the event of the presence of any Hazardous
         Material on any Mortgaged Property which is in violation of any
         Environmental Law or which could reasonably be expected to have
         Environmental Liability which violation or Environmental Liability
         could reasonably be expected to have a Material Adverse Effect, each
         applicable Loan Party and its Subsidiaries, upon discovery thereof,
         shall take all necessary steps to initiate and expeditiously complete
         all response, corrective and other action to mitigate and eliminate any
         such adverse effect in accordance with and to the extent required by
         applicable Environmental Laws, and shall keep the Administrative Agent
         informed of their actions;

                  (d)      at the written request of the Administrative Agent or
         the Requisite Lenders, which request shall specify in reasonable detail
         the basis therefor, each Loan Party will provide, at such Loan Party's
         sole cost and expense, an environmental site assessment report
         concerning any Mortgaged Property now or hereafter owned or leased by
         such Loan Party or any of its respective Subsidiaries, prepared by an
         environmental consulting firm reasonably acceptable to the
         Administrative Agent, indicating the presence or absence of Hazardous
         Materials and the potential cost of any Remedial Action in connection
         with such Hazardous Materials on, at, under or emanating from such
         Mortgaged Property pursuant to any applicable Environmental Law;
         provided that such request may be made only if (i) there has occurred
         and is continuing an Event of Default or (ii) the Administrative Agent
         or the Requisite Lenders reasonably believe that the Borrower or any
         such Mortgaged Property is not in compliance with Environmental Law and
         such noncompliance could reasonably be expected to have a Material
         Adverse Effect, or that circumstances exist that could reasonably be
         expected to form the basis of an Environ-

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<PAGE>

         mental Claim against such Loan Party or to result in Environmental
         Liability, in each case that could reasonably be expected to have a
         Material Adverse Effect (in such events as are listed in this
         subparagraph, the environmental site assessment shall be focused upon
         the noncompliance or other circumstances as applicable). If any Loan
         Party fails to provide the same within 90 days after such request was
         made, the Administrative Agent may order the same, and such Loan Party
         shall grant and hereby grants to the Administrative Agent and the
         Requisite Lenders and their agents access to such Mortgaged Property
         and specifically grants the Administrative Agent and the Requisite
         Lenders an irrevocable non-exclusive license, subject to the rights of
         tenants, to perform such an assessment, all at such Loan Party's sole
         cost and expense; and

                  (e)      provide such information and certifications which the
         Administrative Agent may reasonably request from time to time to
         evidence compliance with this Section 5.06.

                  SECTION 5.07. Information Regarding Collateral. (a) Each year,
at the time of delivery of annual financial statements with respect to the
preceding Fiscal Year pursuant to clause (b) of Section 5.01, the Borrower shall
deliver to the Administrative Agent a certificate of a Financial Officer and the
chief legal officer of the Borrower (i) setting forth the information required
pursuant to Sections 1, 2, 7, 8, 12, 13, 14, 15, 16, 17 and 18 of the Perfection
Certificate or confirming that there has been no change in such information
since the date of the Perfection Certificate delivered on the Effective Date or
the date of the most recent certificate delivered pursuant to this Section and
(ii) certifying that all UCC financing statements (including fixture filings, as
applicable) or other appropriate filings, recordings or registrations, including
all refilings, rerecordings and reregistrations, containing a description of the
Collateral have been filed of record in each governmental, municipal or other
appropriate office in each jurisdiction identified pursuant to clause (i) above
to the extent necessary to protect and perfect the security interests under the
Security Documents for a period of not less than 18 months after the date of
such certificate (except as noted therein with respect to any continuation
statements to be filed within such period).

                  SECTION  5.08. Existence; Conduct of Business. Each Loan Party
will, and will cause each of its respective Subsidiaries to, do or cause to be
done all things necessary to preserve, renew and keep in full force and effect
its legal existence and the rights, licenses, permits, privileges, franchises,
patents, copyrights, trademarks and trade names material to the conduct of its
business; provided that the foregoing shall not prohibit any merger,
consolidation, liquidation or dissolution permitted under Section 6.03.

                  SECTION 5.09. Performance of Obligations. Each Loan Party and
its respective Subsidiaries will perform all of their respective obligations
under the terms of each mortgage, indenture, security agreement, other debt
instrument and material contract by which they are bound or to which they are a
party, except for such noncompliance as individual or in the aggregate would not
have a Material Adverse Effect.

                  SECTION 5.10. Casualty and Condemnation. Each Loan Party (a)
will furnish to the Administrative Agent and the Lenders prompt written notice
of any casualty or other in-

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sured damage to any Collateral in an amount in excess of $5.0 million or the
commencement of any action or proceeding for the Taking of any Collateral or any
part thereof or interest therein under power of eminent domain or by
condemnation or similar proceeding and (b) will ensure that the Net Proceeds of
any such event (whether in the form of insurance proceeds, condemnation awards
or otherwise) are collected and applied in accordance with the applicable
provisions of this Agreement and the Security Documents.

                  SECTION 5.11. Pledge of Additional Collateral. In any event
within 30 days after the acquisition of assets of the type that would have
constituted Collateral on the Effective Date pursuant to the Security Documents
(the "Additional Collateral"), each appropriate Loan Party will, and will cause
its respective Restricted Subsidiaries to, take all necessary action, including
the filing of appropriate financing statements under the provisions of the UCC,
applicable domestic or local laws, rules or regulations in each of the offices
where such filing is necessary or appropriate, or entering into or amending the
Guarantee Agreement and the Security Documents, or in the case of the Equity
Interests of a "first tier" Non-U.S. Subsidiary organized in a Non-U.S.
Jurisdiction specified on Schedule 4.01(c), entering into a Non-U.S. Pledge
Agreement providing for the relevant Loan Party to have an enforceable and
perfected security interest in 65% of the voting Equity Interests and 100% of
the non-voting Equity Interests in such Subsidiary, to grant to the Collateral
Agent for its benefit and the benefit of the Secured Parties a perfected first
priority Lien in such Collateral pursuant to and to the full extent required by
the Security Documents and this Agreement (including, without limitation,
satisfaction of the conditions set forth in subsections (c) and (x) of Section
4.01). In the event that any Loan Party or its respective Subsidiaries acquire
an interest in additional Real Property having a fair market value in excess of
$2.0 million as determined in good faith by the Borrower or renews or enters
into any new lease of Real Property for a term of one (1) year or more (whether
or not the subject of a leasehold mortgage under the Security Documents on the
Effective Date) for space in excess of 50,000 rentable square feet and with
respect to a facility where manufacturing and/or research activities are
undertaken, the Borrower or the appropriate Loan Party or Restricted Subsidiary,
as the case may be, and using its commercially reasonable efforts in respect of
any such leases, will take such actions and execute such documents as the
Collateral Agent shall reasonably require to confirm the Lien of a Mortgage, if
applicable, or to create a new Mortgage (including, without limitation,
satisfaction of the conditions set forth in subsections (c) and (y) of Section
4.01, if not previously fulfilled by the Borrower or such Loan Party with
respect to such new Collateral). All actions taken by the parties in connection
with the pledge of Additional Collateral, including, without limitation, costs
of counsel for the Administrative Agent and the Collateral Agent, shall be for
the account of the Borrower, which shall pay all sums due on demand.

                  SECTION 5.12. Further Assurances. The Loan Parties will, and
will cause each Restricted Subsidiary of a Loan Party to, execute any and all
further documents, financing statements, agreements and instruments, and take
all such further actions (including the filing and recording of financing
statements, fixture filings, mortgages, deeds of trust and other documents and
the delivery of appropriate opinions of counsel), which may be required under
any applicable law, or which the Administrative Agent or the Requisite Lenders
may reasonably request, to effectuate the transactions contemplated by the Loan
Documents or to grant, preserve, protect or perfect the Liens created by the
Security Documents or the validity or priority of any

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such Lien, all at the expense of the Loan Parties. The Loan Parties also agree
to provide to the Administrative Agent, from time to time upon request, evidence
reasonably satisfactory to the Administrative Agent as to the perfection and
priority of the Liens created or intended to be created by the Security
Documents.

                  Without limiting the foregoing, the Loan Parties shall comply
with the provisions of Section 2(a) of the Pledge Agreement (regarding actions
in furtherance of perfecting the Lien of the Collateral Agent in certain
Collateral) within the time periods specified (unless extended or waived by the
Collateral Agent).

                  SECTION 5.13. Use of Proceeds. The Borrower covenants and
agrees that (i) the proceeds of the Term B Loan Borrowings hereunder will be
used on the Effective Date to pay the aggregate Per Share Amount (as defined in
the Merger Agreement) in the Merger and to pay Fees and expenses payable
hereunder, (ii) all Revolving Credit Borrowings will be used for general
corporate purposes; provided that if the proceeds thereof are used to make an
Investment, after giving effect to such Borrowing, the sum of (A) the Total
Revolving Credit Commitment less the Revolving Credit Exposure of all Revolving
Lenders, plus (B) cash and/or Permitted Investments on the latest balance sheet
of the Borrower that has been delivered to Lenders pursuant to Section 5.01(a)
or (b) (with such Permitted Investments valued at the amount set forth on such
balance sheet), shall not be less than $75.0 million and (iii) all Foreign
Currency Loans shall be advanced to one or more Non-U.S. Subsidiaries pursuant
to an Intercompany Note that is pledged to the Secured Parties pursuant to the
Security Documents.

                  SECTION 5.14. Payment of Taxes. Each Loan Party and its
respective Subsidiaries will pay and discharge all material taxes, assessments
and governmental charges or levies imposed upon it or upon its income or
profits, or upon any Properties belonging to it, prior to the date on which
material penalties attach thereto, and all lawful claims which, if unpaid, might
become a Lien or charge upon any Properties of such Loan Party or any of its
respective Subsidiaries or cause a failure or forfeiture of title thereto;
provided that neither such Loan Party nor any of its respective Subsidiaries
shall be required to pay any such tax, assessment, charge, levy or claim that is
being contested in good faith and by proper proceedings diligently conducted,
which proceedings have the effect of preventing the forfeiture or sale of the
Property or asset that may become subject to such Lien, if it has maintained
adequate reserves with respect thereto in accordance with and to the extent
required under GAAP; provided, further, that any such contest of any tax,
assessment, charge, levy or claim with respect to Collateral shall satisfy the
Contested Collateral Lien Conditions.

                  SECTION 5.15. Equal Security for Loans and Notes. If any Loan
Party shall create or assume any Lien upon any of its property or assets,
whether now owned or hereafter acquired, other than Permitted Liens (unless
prior written consent to the creation or assumption thereof shall have been
obtained from the Administrative Agent and the Requisite Lenders), it shall make
or cause to be made effective provisions whereby the Obligations will be secured
by such Lien equally and ratably with any and all other assets or Property
thereby secured as long as any such assets or Property shall be secured;
provided that this covenant shall not be construed as

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consent by the Administrative Agent and the Requisite Lenders to any violation
by any Loan Party of the provisions of Section 6.02.

                  SECTION 5.16. Guarantees. In the event that (i) any Domestic
Subsidiary of the Borrower existing on the Effective Date has not previously
executed the Guarantee Agreement, (ii) any Person becomes a Domestic Subsidiary
of the Borrower after the Effective Date, or (iii) any Subsidiary that
Guarantees any other Indebtedness of the Borrower or any Domestic Subsidiary,
the Borrower will promptly notify the Administrative Agent of that fact and
cause such Subsidiary to execute and deliver to the Administrative Agent a
counterpart of the Guarantee Agreement and deliver to the Collateral Agent a
counterpart of the Security Agreement and the Pledge Agreement and to take all
such further actions and execute all such further documents and instruments
(including actions, documents and certificates comparable to those described in
Sections 4.01(c), (e) and (f)) as may be necessary or, in the reasonable opinion
of the Administrative Agent, desirable to create in favor of the Collateral
Agent, for the benefit itself and of the Secured Parties, a valid and perfected
first priority Lien on all of the Property and assets of such Subsidiary
described in the applicable forms of the Security Documents.

                  SECTION 5.17. Subordination of Loans. Each Loan Party
covenants and agrees that any existing and future loans from any Subsidiary that
is not a Loan Party to either of the Parent Guarantors, the Borrower or any
Subsidiary Loan Party shall be subordinated (to the extent legally permitted) to
the Obligations pursuant to a written agreement to at least the same extent as
the Subordinated Notes are subordinated to the Obligations.

                  SECTION 5.18. Unrestricted Subsidiaries. Each Loan Party shall
ensure that all financial statements of each Unrestricted Subsidiary distributed
to any creditor of an Unrestricted Subsidiary clearly states the separateness of
such Unrestricted Subsidiary from the Loan Parties.

                  SECTION 5.19. Non-Pledgeable Permitted PharmaBio Investments.
(a) Within 60 days after the Effective Date, unless otherwise extended or waived
by the Administrative Agent in its reasonable discretion, the Borrower shall
create a newly-formed Wholly Owned Domestic Subsidiary that will become a party
to the Guarantee Agreement ("New Investment Subsidiary"), pledge 100% of the New
Investment Subsidiary's Equity Interests pursuant to the Pledge Agreement and
transfer to such New Investment Subsidiary all Permitted PharmaBio Investments
(or other securities) owned by the Borrower or any Subsidiary Loan Party on the
Effective Date and that are (i) not pledged in favor of the Collateral Agent
under the Pledge Agreement and (ii) not subsequently disposed of; provided,
however, the failure to transfer any security to such New Investment Subsidiary
shall not constitute a breach of this covenant if such transfer is prohibited by
the terms of any agreement related to such security and the applicable Loan
Party has used commercially reasonable efforts to obtain all required consents
to such transfer.

                  (b) The New Investment Subsidiary shall not conduct any
business or hold any assets or have any operations (other than holding Permitted
PharmaBio Investments (or other securities) and actions reasonably related
thereto). Each Loan Party shall promptly transfer any Permitted PharmaBio
Investments (or other securities) acquired in the future by such Loan Party

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(other than the New Investment Subsidiary) that are by their terms not permitted
to be pledged under the Pledge Agreement to the New Investment Subsidiary;
provided, however, the failure to transfer any security to such New Investment
Subsidiary shall not constitute a breach of this covenant if such transfer is
prohibited under the terms of any agreement related to such security and the
applicable Loan Party has used commercially reasonable efforts to obtain all
required consents to such transfer.

                  SECTION 5.20. Additional Mortgages. (a) The Loan Parties, as
appropriate, will use commercially reasonable efforts (unless waived or extended
by the Collateral Agent in its discretion) to obtain, within sixty (60) days
after the Effective Date, the property owners' consent to leasehold mortgage
financing with respect to the properties located at 475 Brannan Street, San
Francisco, CA and 10 Waterview Boulevard, Parsippany, NJ, and if such consent is
so obtained with respect to either or both of such properties, the Loan Parties,
as appropriate, will use commercially reasonably efforts to deliver within
thirty (30) days thereafter the following:

                  (i)      a duly executed and acknowledged Mortgage, financing
         statements and other instruments meeting the requirements of Section
         4.01(y)(A) hereof;

                  (ii)     such consents, approvals, amendments, supplements,
         estoppels, tenant subordination agreements or other instruments as
         required by Section 4.01(y)(B);

                  (iii)    a policy of title insurance meeting the requirements
         of Section 4.01(y)(C);

                  (iv)     policies or certificates of insurance as required by
         Section 4.01(y)(D);

                  (v)      a Survey meeting the requirements of Section
         4.01(y)(E);

                  (vi)     such affidavits, certificates, information (including
         financial data) and instruments of indemnification (including, without
         limitation, a so-called "gap" indemnification) as required by Section
         4.01(y)(F);

                  (vii)    evidence of payment of all applicable premiums,
         charges, costs, taxes, etc. as required by Section 4.01(y)(G);

                  (viii)   copies of all leases or other agreements, and
         subordination of such, as required by Section 4.01(y)(H);

                  (ix)     an Officers' Certificate as required by Section
         4.01(y)(I); and

                  (x)      favorable written opinions of local counsel as
         required by Section 4.01(c)(iv).

                  SECTION 5.21. Foreign Pledges. (a) Within 30 days after the
Effective Date unless otherwise extended or waived by the Collateral Agent in
its discretion, (i) the Borrower shall have authorized, executed and delivered
all documents and taken all actions necessary or appropriate to grant in favor
of the Collateral Agent a first priority pledge of 65% of the voting

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Equity Interests and 100% of the non-voting Equity Interests in Quintiles AG
under the laws of Switzerland (including, without limitation, the taking of all
actions or the foreign equivalent, if applicable, and the delivery of all items,
or their foreign equivalent, if applicable, of the type and nature enumerated in
Section 4.01(w) of this Agreement, the delivery of all certificates, agreements
or instruments representing such Equity Interest of Quintiles AG, accompanied by
instruments of transfer endorsed in blank to the extent required or permitted
under the jurisdiction or organization of the applicable issuer of such Equity
Interests and the payment of all fees in connection therewith) and (ii) the
Collateral Agent shall have received, on behalf of itself, the other Agents and
the Lenders, a favorable written opinion of counsel in Switzerland as shall be
acceptable to the Collateral Agent, (a) dated no later than such 30th day after
the Effective Date, (b) addressed to the Collateral Agent and the Lenders and
(c) covering such matters relating to the Security Documents and the Loan
Documents as the Collateral Agent shall request.

                                   ARTICLE VI

                               NEGATIVE COVENANTS

                  Until the Commitments have expired or terminated and the
principal of and interest on each Loan and all Fees and other amounts payable
hereunder or under any other Loan Document have been paid in full and all
Letters of Credit have expired or terminated and all LC Disbursements shall have
been reimbursed, each of the Loan Parties and their respective Subsidiaries
(other than Unrestricted Subsidiaries, except as expressly specified below)
agree with the Lenders that:

                  SECTION 6.01. Indebtedness; Certain Equity Securities. (a) The
Loan Parties will not, and will not permit any of their Restricted Subsidiaries
to, directly or indirectly, create, incur, assume or permit to exist (including
by way of Guarantee) any Indebtedness, except:

                  (i)      Indebtedness incurred and outstanding under the Loan
         Documents;

                  (ii)     (A) Indebtedness of the Loan Parties incurred and
         outstanding under the Subordinated Notes in an aggregate principal
         amount not to exceed $450 million and (B) any refinancings thereof with
         Permitted Subordinated Indebtedness; provided that in the case of this
         clause (B) only, (x) no Default or Event of Default shall have occurred
         or be continuing or would result therefrom, (y) after giving effect to
         the incurrence of such Indebtedness (and any other Indebtedness
         incurred since the last day of the immediately preceding Test Period)
         on a pro forma basis as if it were incurred on the first day of the
         immediately preceding Test Period (but tested as if the applicable
         ratio were the ratio for the next succeeding Test Period), the Borrower
         would be in compliance with Sections 6.13 through 6.16, inclusive, and
         (z) the amount of such Indebtedness is not increased at the time of
         such refinancing, except by an amount equal to any reasonable
         prepayment premium on such Indebtedness being refinanced and fees and
         expenses reasonably incurred in connection with such refinancing;

                  (iii)    Indebtedness existing on the Effective Date and set
         forth in Schedule 6.01(a)(iii) and any renewals, refinancings and
         extensions thereof on terms and condi-

                                      -95-

<PAGE>

         tions (other than interest rates and other terms which fluctuate with
         general market conditions) no less favorable to such Person than such
         existing Indebtedness; provided that the amount of such Indebtedness is
         not increased at the time of such refinancing, refunding, renewal or
         extension except by an amount equal to any reasonable prepayment
         premium on such Indebtedness being refinanced and fees and expenses
         reasonably incurred in connection with such refinancing and by an
         amount equal to any existing commitment unutilized thereunder, and such
         refinanced Indebtedness matures no earlier than the Indebtedness being
         refinanced;

                  (iv)     (x) Indebtedness of the Borrower to any Subsidiary
         Loan Party (other than Bioglan) and of any Subsidiary Loan Party to the
         Borrower or any other Subsidiary Loan Party (other than Bioglan), or
         (y) Indebtedness of any Non-U.S. Subsidiary owed to a Wholly Owned
         Non-U.S. Subsidiary, including, pursuant to any cash management
         facility;

                  (v)      Guarantees by the Borrower of Indebtedness of any
         Subsidiary Loan Party and by any Subsidiary Loan Party (other than
         Bioglan) of Indebtedness of the Borrower or any other Subsidiary Loan
         Party (other than Bioglan), in each case, to the extent such
         Indebtedness was permitted to be incurred hereunder, and if such
         Indebtedness is subordinated to the Obligations under the Loan
         Documents, such Guarantee is as subordinated in right of payment to the
         Obligations;

                  (vi)     Indebtedness arising from the honoring by a bank or
         other financial institution of a check, draft or similar instrument
         drawn against insufficient funds in the ordinary course of business;
         provided that such Indebtedness is extinguished within two Business
         Days of its incurrence;

                  (vii)    Indebtedness of Non-U.S. Subsidiaries in an aggregate
         principal amount outstanding at any time not in excess of $40.0
         million; provided that (x) no Default or Event of Default shall have
         occurred or be continuing or would result therefrom and (y) after
         giving effect to the incurrence of such Indebtedness (and any other
         Indebtedness incurred since the last day of the immediately preceding
         Test Period) on a pro forma basis as if it was incurred on the first
         day of the immediately preceding Test Period (but tested as if the
         applicable ratio were the ratio for the next succeeding Test Period),
         the Borrower would be in compliance with Sections 6.13 through 6.16,
         inclusive;

                  (viii)   (A) Indebtedness of any Non-U.S. Subsidiary to the
         Borrower or any Subsidiary Loan Party (other than Bioglan) in an
         aggregate principal amount outstanding at any time not in excess of
         $50.0 million; provided that any such Indebtedness that exceeds
         $500,000 in principal amount shall be evidenced by a promissory note
         and shall be pledged pursuant to the Pledge Agreement; and (B)
         Indebtedness of any Wholly Owned Non-U.S. Subsidiary in the form of a
         promissory note that is issued to the Borrower or a Subsidiary Loan
         Party (other than Bioglan) as a dividend or return of capital by such
         Wholly Owned Non-U.S. Subsidiary; provided that such promissory note is
         pledged pursuant to the Pledge Agreement;

                                      -96-

<PAGE>

                  (ix)     Indebtedness of any Wholly Owned Non-U.S. Subsidiary
         (other than any Designated Asian Subsidiary) to the Borrower or any
         Subsidiary Loan Party representing (1) the deferred payment of the
         purchase price for the sale of Equity Interests of a Non-U.S.
         Subsidiary (other than any Designated Asian Subsidiary) by the Borrower
         or a Subsidiary Loan Party (other than Bioglan) to such Wholly Owned
         Non-U.S. Subsidiary, (2) an allocation of development costs for
         intellectual property used by such Wholly Owned Non-U.S. Subsidiary and
         (3) a management or other fee owed to the Borrower for services
         provided by the Borrower or a Subsidiary Loan Party (other than
         Bioglan) to such Wholly Owned Non-U.S. Subsidiary; provided that (a) in
         each case, such Indebtedness that exceeds $500,000 in principal amount
         individually or in the aggregate shall be evidenced by a promissory
         note and shall be pledged pursuant to the Pledge Agreement and (b) in
         the case of clause (1), 65% of the voting Equity Interests and 100% of
         the non-voting Equity Interests of such Wholly Owned Non-U.S.
         Subsidiary or the "first tier" holding company thereof that is a Wholly
         Owned Non-U.S. Subsidiary shall be pledged pursuant to a Non-U.S.
         Pledge Agreement;

                  (x)      Indebtedness of the Borrower or any Restricted
         Subsidiary incurred to finance the acquisition, construction or
         improvement of any fixed or capital assets, including Capital Lease
         Obligations and any Indebtedness assumed in connection with the
         acquisition of any such assets or secured by a Lien on any such assets
         prior to the acquisition thereof, and extensions, renewals and
         replacements of any such Indebtedness that do not increase the
         outstanding principal amount thereof or result in an earlier maturity
         date or decreased weighted average life thereof; provided that (A) such
         Indebtedness is incurred prior to or within 90 days after such
         acquisition or the completion of such construction or improvement and
         (B) the aggregate principal amount of Indebtedness permitted by this
         clause (x) shall not exceed $50.0 million at any time outstanding;

                  (xi)     Hedging Agreements entered into in the ordinary
         course of business and not for speculative purposes;

                  (xii)    Indebtedness owed to (including obligations in
         respect of letters of credit for the benefit of) any Person providing
         worker's compensation, health, disability or other employee benefits or
         property, casualty or liability insurance to the Borrower or any
         Restricted Subsidiary, pursuant to reimbursement or indemnification
         obligations to such Person;

                  (xiii)   Indebtedness of the Borrower and its Restricted
         Subsidiaries in respect of performance bonds, bid bonds, appeal bonds,
         surety bonds and similar obligations and trade-related letters of
         credit, in each case provided in the ordinary course of business,
         including those incurred to secure health, safety and environmental
         obligations in the ordinary course of business;

                  (xiv)    Indebtedness arising from agreements of the Borrower
         or any Restricted Subsidiary of the Borrower providing for
         indemnification, adjustment of purchase price or similar obligations,
         in each case, incurred or assumed in connection with the disposition of
         any business, assets or a Restricted Subsidiary, other than Guarantees
         of Indebt-

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<PAGE>

         edness incurred by any Person acquiring all or any portion of such
         business, assets or a Restricted Subsidiary for the purpose of
         financing such acquisition;

                  (xv)     obligations in respect of performance and surety
         bonds and completion guarantees provided by the Borrower or any
         Restricted Subsidiary in the ordinary course of business;

                  (xvi)    Permitted Subordinated Indebtedness in an aggregate
         principal amount outstanding not to exceed $50.0 million; provided that
         (x) no Default or Event of Default shall have occurred or be continuing
         or would result therefrom and (y) after giving effect to the incurrence
         of such Indebtedness (and any other Indebtedness incurred since the
         last day of the immediately preceding Test Period) on a pro forma basis
         as if it was incurred on the first day of the immediately preceding
         Test Period (but tested as if the applicable ratio were the ratio for
         the next succeeding Test Period), the Borrower would be in compliance
         with Sections 6.13 through 6.16, inclusive;

                  (xvii)   Indebtedness of a Person existing at the time such
         Person becomes a Restricted Subsidiary of the Borrower in connection
         with a Permitted Acquisition, but only if such Indebtedness was not
         created or incurred in contemplation of such Person becoming a
         Restricted Subsidiary; provided that (x) no Default or Event of Default
         shall have occurred or be continuing or would result therefrom and (y)
         after giving effect to the incurrence of such Indebtedness (and any
         other Indebtedness incurred since the last day of the immediately
         preceding Test Period) on a pro forma basis as if it was incurred on
         the first day of the immediately preceding Test Period (but tested as
         if the applicable ratio were the ratio for the next succeeding Test
         Period), the Borrower would be in compliance with Sections 6.13 through
         6.16, inclusive;

                  (xviii)  other unsecured Indebtedness of the Borrower or any
         Restricted Subsidiary in an aggregate principal amount not exceeding
         $50.0 million at any time outstanding;

                  (xix)    other secured Indebtedness of the Borrower or any
         Restricted Subsidiary in an aggregate principal amount not exceeding
         $10.0 million at any time outstanding;

                  (xx)     deferred payment obligations under the employment
         agreements identified on Schedule 6.01(a)(xx);

                  (xxi)    Indebtedness of any Loan Party owed to any Non-U.S.
         Subsidiary; provided, that such Indebtedness is subordinated
         (including, without limitation, a prohibition on enforcement) to the
         Obligations on terms and conditions satisfactory to the Administrative
         Agent; and

                  (xxii)   Permitted Discount Notes raising gross proceeds not
         to exceed $125.0 million issued by the Intermediate Parent; provided
         that within 60 days of the issuance of such Permitted Discount Notes,
         so long as no Default or Event of Default has occurred and is
         continuing, the Intermediate Parent (A) distributes the net proceeds of
         the issuance

                                      -98-

<PAGE>

         of such Permitted Discount Notes to the Parent pursuant to Section
         6.07(ix), (B) contributes the net proceeds of the issuance of such
         Permitted Discount Notes to the equity capital of the Borrower or (C)
         distributes and/or contributes such net proceeds in any combination of
         clauses (A) and (B) above; provided further, that during such 60 day
         period such net proceeds are held in a deposit account in which the
         Collateral Agent has a perfected first priority security interest.

                  (b)      The Loan Parties will not, nor will they permit any
of their Restricted Subsidiaries to, directly or indirectly, issue any Preferred
Stock or other preferred Equity Interest (other than a Non-U.S. Subsidiary
issuing Preferred Stock or other preferred Equity Interest to the Borrower or a
Subsidiary Loan Party that is permitted to be issued by Section 6.04(iv)) which
(i) matures or is mandatorily redeemable pursuant to a sinking fund obligation
or otherwise, (ii) is or may become redeemable or repurchaseable at the option
of the holder thereof, in whole or in part, or (iii) is convertible or
exchangeable at the option of the holder thereof for Indebtedness or Preferred
Stock or any other preferred Equity Interest described in this paragraph.

                  SECTION 6.02. Liens. The Loan Parties will not, and will not
permit any of their Restricted Subsidiaries to, directly or indirectly, create,
incur, assume or permit to exist any Lien on any Property or asset now owned or
hereafter acquired by them, or assign or sell any income or revenues (including
accounts receivable) or rights in respect of any thereof, except the following
(herein collectively referred to as "Permitted Liens"):

                  (i)      Liens in favor of the Collateral Agent under the
         Security Documents;

                  (ii)     Liens on assets acquired after the Effective Date
         existing at the time of acquisition thereof by the Borrower or any
         Restricted Subsidiary; provided that such Liens were not incurred in
         connection with, or in contemplation of, such acquisition and do not
         extend to any assets of the Borrower or any Restricted Subsidiary other
         than the specific assets so acquired;

                  (iii)    Liens to secure the performance of statutory
         obligations, surety or appeal bonds or performance bonds, landlords',
         carriers', warehousemen's, mechanics', suppliers', materialmen's,
         attorney's or other like liens, in any case incurred in the ordinary
         course of business and with respect to amounts not yet delinquent or
         being contested in good faith by appropriate proceedings promptly
         instituted and diligently conducted; provided that (A) a reserve or
         other appropriate provision, if any, as is required by GAAP shall have
         been made therefor, (B) if such Lien is on Collateral, the Contested
         Collateral Lien Conditions shall at all times be satisfied and (C) such
         Liens relating to statutory obligations, surety or appeal bonds or
         performance bonds shall only extend to or cover cash and Permitted
         Investments not in the Collateral Account;

                  (iv)     Liens existing on the Effective Date and identified
         on Schedule 6.02 to the extent permitted by the applicable Security
         Documents;

                  (v)      Liens for taxes, assessments or governmental charges
         or claims or other like statutory Liens, in any case incurred in the
         ordinary course of business, that do not

                                      -99-

<PAGE>

         secure Indebtedness for borrowed money and (A) that are not yet
         delinquent or (B) that are being contested in good faith by appropriate
         proceedings promptly instituted and diligently concluded; provided that
         (1) any reserve or other appropriate provision as shall be required in
         conformity with GAAP shall have been made therefor and (2) if such Lien
         is on Collateral, the Contested Collateral Lien Conditions shall at all
         times be satisfied;

                  (vi)     Liens to secure Indebtedness (including Capital Lease
         Obligations) of the type described in Section 6.01(a)(x) covering only
         the assets acquired or improved with such Indebtedness;

                  (vii)    Liens on the assets of a Non-U.S. Subsidiary that are
         not otherwise Collateral which Liens secure such Non-U.S. Subsidiary's
         obligations under Indebtedness incurred pursuant to Section
         6.01(a)(vii);

                  (viii)   Liens securing Indebtedness incurred to refinance
         Indebtedness secured by the Liens of the type described in clauses (ii)
         and (vii) of this Section 6.02; provided that any such Lien shall not
         extend to or cover any assets not securing the Indebtedness so
         refinanced;

                  (ix)     (A) Liens in the form of zoning restrictions,
         easements, licenses, reservations, covenants, conditions or other
         restrictions on the use of real property or other minor irregularities
         in title (including leasehold title) that do not (1) secure
         Indebtedness or (2) have a Material Adverse Effect, individually or in
         the aggregate, or materially impair the use of the real property in the
         ordinary course of business of the Borrower and any Restricted
         Subsidiary at such real property and (B) with respect to leasehold
         interests in real property, mortgages, obligations, liens and other
         encumbrances incurred, created, assumed or permitted to exist and
         arising by, through or under a landlord or owner of such leased
         property encumbering the landlord's or owner's interest in such leased
         property;

                  (x)      Liens in the form of pledges or deposits securing
         bids, tenders, contracts (other than contracts for the payment of
         money) or leases to which the Borrower or any Subsidiary is a party, in
         each case, made in the ordinary course of business for amounts (A) not
         yet due and payable or (B) being contested in good faith by appropriate
         proceedings promptly instituted and diligently conducted; provided that
         (1) a reserve or other appropriate provision, if any, as is required by
         GAAP shall have been made therefor, (2) if such Lien is on Collateral,
         the Contested Collateral Lien Conditions shall at all times be
         satisfied and (3) such Liens shall in no event encumber any Collateral
         other than cash and Cash Equivalents not in the Collateral Account;

                  (xi)     Liens resulting from operation of law with respect to
         any judgments, awards or orders to the extent that such judgments,
         awards or orders do not cause or constitute a Default under this
         Agreement; provided that if any such Liens are on Collateral, the
         Contested Collateral Lien Conditions shall at all times be satisfied;

                  (xii)    Liens in the form of licenses, leases or subleases
         granted or created by the Borrower or any Restricted Subsidiary, which
         licenses, leases or subleases do not inter-

                                      -100-

<PAGE>

         fere, individually or in the aggregate, in any material respect with
         the business of the Borrower or such Restricted Subsidiary or
         individually or in the aggregate materially impair the use (for its
         intended purpose) or the value of the Property subject thereto;
         provided that (x) to the extent such licenses, leases or subleases
         relate to Mortgaged Property in existence as of the Effective Date, the
         Borrower or such Restricted Subsidiary shall use its commercially
         reasonable efforts to as soon as practicable cause such licenses,
         leases or subleases to be subordinated to the Lien granted and
         evidenced by the Security Documents in accordance with the provisions
         thereof and (y) with respect to Mortgaged Property, to the extent
         entered into after the Effective Date, such licenses, leases or
         subleases shall be subordinate to the Lien granted and evidenced by the
         Security Documents in accordance with the provisions thereof; provided,
         further, that any such Lien shall not extend to or cover any asset of
         the Parent Guarantors, the Borrower or any Subsidiary that is not the
         subject of any such license, lease or sublease;

                  (xiii)   Liens on fixtures or personal property held by or
         granted to landlords pursuant to leases to the extent that such Liens
         are not yet due and payable; provided that (i) with respect to any such
         Liens in existence on the Effective Date, the Borrower or any
         applicable Restricted Subsidiary has used its commercially reasonable
         efforts to obtain a landlord lien waiver reasonably satisfactory to the
         Collateral Agent and (ii) with respect to any leases entered into after
         the Effective Date, the Borrower or any applicable Restricted
         Subsidiary shall use its commercially reasonable efforts to (x) enter
         into a lease that does not grant a Lien on fixtures or personal
         property in favor of the landlord thereunder or (y) obtain a landlord
         lien waiver reasonably satisfactory to the Collateral Agent;

                  (xiv)    Liens on Permitted PharmaBio Investments consisting
         of call rights, purchase options or transfer restrictions by the issuer
         of the applicable securities or pursuant to shareholders agreements or
         other similar agreements;

                  (xv)     Liens on assets or property that does not constitute
         Collateral that secure Indebtedness permitted to be incurred pursuant
         to Section 6.01(a)(xix); and

                  (xvi)    Liens securing Indebtedness permitted by Section
         6.01(a)(xvii); provided that such Liens existed prior to such Person
         becoming a Restricted Subsidiary, were not created in anticipation
         thereof and attach only to specific assets of such Person that is the
         subject of the Permitted Acquisition;

provided, however, that (x) no Liens shall be permitted to exist, directly or
indirectly, on any Collateral (as defined in the Pledge Agreement) or on any
Securities (as defined in the Security Agreement), other than Liens in favor of
the Collateral Agent and Liens permitted by Sections 6.02 (v), (xi) and (xiv)
and (y) no Liens shall be permitted to exist, directly or indirectly, on a
Permitted PharmaBio Investment, other than Liens in favor of the Collateral
Agent and Liens permitted by Sections 6.02(v), (xi) and (xiv).

                  SECTION 6.03. Fundamental Changes. (a) The Loan Parties will
not, and will not permit any of their Restricted Subsidiaries to, directly or
indirectly, merge into or consolidate with any other Person, or permit any other
Person to merge into or consolidate with them, or liq-

                                      -101-

<PAGE>

uidate or dissolve, except that, if at the time thereof and immediately after
giving effect thereto no Default or Event of Default shall have occurred and be
continuing, (i) any Wholly Owned Restricted Subsidiary (other than Bioglan) may
merge into the Borrower in a transaction in which the Borrower is the surviving
corporation, (ii) any Wholly Owned Restricted Subsidiary (other than Bioglan)
may merge with or into any Wholly Owned Restricted Subsidiary (other than
Bioglan) in a transaction in which the surviving entity is a Wholly Owned
Restricted Subsidiary and (if any party to such merger is a Subsidiary Loan
Party) is a Subsidiary Loan Party, (iii) any Unrestricted Subsidiary may merge
into another Unrestricted Subsidiary and (iv) Permitted Acquisitions may be
consummated so long as the surviving person of any merger or consolidation is
the Borrower, a Subsidiary Loan Party or a Wholly Owned Non-U.S. Subsidiary;
provided that in connection with the foregoing, the appropriate Loan Parties
shall take all actions necessary or reasonably requested by the Collateral Agent
to maintain the perfection of or perfect, as the case may be, protect and
preserve the Liens on the Collateral granted to the Collateral Agent pursuant to
the Security Documents and otherwise comply with the provisions of Sections 5.11
and 5.12, in each case, on the terms set forth therein and to the extent
applicable.

                  (b)      Notwithstanding the foregoing, any Subsidiary Loan
Party may dispose of any or all of its assets (upon voluntary liquidation or
otherwise) to the Borrower or any other Subsidiary Loan Party (other than
Bioglan) (provided that in connection with the foregoing, the appropriate Loan
Parties shall take all actions necessary or reasonably requested by the
Collateral Agent to maintain the perfection of or perfect, as the case may be,
protect and preserve the Liens on the Collateral granted to the Collateral Agent
pursuant to the Security Documents and otherwise comply with the provisions of
Sections 5.11 and 5.12, in each case, on the terms set forth therein and to the
extent applicable), and any Restricted Subsidiary which is not a Subsidiary Loan
Party other than Bioglan may dispose of assets to any other Wholly Owned
Restricted Subsidiary which is not a Subsidiary Loan Party (other than Bioglan).

                  (c)      The Borrower will not, and will not permit any of its
Subsidiaries (including Unrestricted Subsidiaries) to, directly or indirectly,
engage in any business other than businesses of the type conducted by the
Borrower and the Subsidiaries on the Effective Date and businesses reasonably
related thereto.

                  SECTION 6.04. Investments, Loans, Advances, Guarantees and
Acquisitions. The Loan Parties will not, and will not permit any of their
Restricted Subsidiaries to, directly or indirectly, purchase, hold or acquire
(including pursuant to any merger with any Person that was not a Wholly Owned
Subsidiary prior to such merger) any Equity Interests in or evidences of
Indebtedness or other securities (including any option, warrant or other right
to acquire any of the foregoing) of, make or permit to exist any loans or
advances to or other extensions of credit, Guarantee any obligations of, or make
or permit to exist any investment or any other interest in, any other Person, or
make any other payment for property or services for the account or use of any
other Person (other than expenses incurred in the ordinary course of business or
as required pursuant to agreements entered into in connection with Permitted
PharmaBio Investments) or make any upfront milestone, marketing or other funding
payment to another Person in connection with obtaining a right to receive
royalty or other payments in the future, or purchase or otherwise acquire (in
one transaction or a series of transactions) any assets of any other Person
con-

                                      -102-

<PAGE>

stituting a business unit (each of the foregoing, an "Investment" and
collectively, "Investments"), except:

                  (i)      Permitted Investments;

                  (ii)     Investments existing on the Effective Date (or in
         respect of which a binding commitment to make such Investment exists on
         the Effective Date) (including, without limitation, Permitted PharmaBio
         Investments as of the Effective Date) and set forth on Schedule 6.04;

                  (iii)    Investments by the Parent in the Intermediate Parent
         and by the Intermediate Parent in the Borrower and by or among the
         Borrower and the Restricted Subsidiaries in Subsidiary Loan Parties
         (other than Investments in Bioglan); provided that any such Investment
         held by a Loan Party shall be pledged pursuant to a Pledge Agreement;

                  (iv)     (a) Investments made after the Effective Date by the
         Borrower and its Restricted Subsidiaries in Equity Interests of
         Non-U.S. Subsidiaries and (b) Investments that would otherwise
         constitute a Permitted PharmaBio Investment or a Permitted Acquisition
         but for the fact that such Investment is made by a Wholly Owned
         Non-U.S. Subsidiary; provided, that the aggregate amount of Investments
         made pursuant to this clause (iv) shall not exceed $50.0 million at any
         time; provided, further, that such limitation shall not be applied to
         Investments specified in clause (a) consisting solely of the
         capitalization of loans to Non-U.S. Subsidiaries otherwise permitted
         under this Agreement;

                  (v)      Investments constituting Indebtedness permitted by
         Sections 6.01(a)(iv), (viii), (ix) and (xi);

                  (vi)     Guarantees constituting Indebtedness permitted by
         Section 6.01(a)(v);

                  (vii)    Investments by a Wholly Owned Non-U.S. Subsidiary in
         another Wholly Owned Non-U.S. Subsidiary;

                  (viii)   Investments received in connection with the
         bankruptcy or reorganization of, or settlement of delinquent accounts
         and disputes with, customers and suppliers, in each case in the
         ordinary course of business;

                  (ix)     loans and advances to employees of the Parent, the
         Borrower or their Restricted Subsidiaries (A) in the ordinary course of
         business (including, without limitation, for travel, entertainment and
         relocation expenses) not to exceed $8.0 million in the aggregate at any
         time outstanding or (B) for the purpose of purchasing Equity Interests
         in the Parent Guarantors not to exceed $5.0 million in the aggregate at
         any time outstanding;

                  (x)      Permitted PharmaBio Investments since the Effective
         Date not to exceed in the aggregate the sum of (x) $150.0 million plus
         (y) Cumulative Excess Cash Flow plus (z) any net cash amounts (for
         avoidance of doubt, excluding any Investment received in a Permitted
         PharmaBio Swap) received in respect of the sale or disposition or

                                      -103-

<PAGE>

         satisfaction of obligations of or with respect to any Permitted
         PharmaBio Investments (other than the sale or disposition of marketable
         securities (as set forth on the Borrower's balance sheet in accordance
         with GAAP) held by the Borrower or any of its Subsidiaries on the
         Effective Date) to the extent such amount does not exceed the original
         amount of such Investment (exclusive of any write-up or write-down);

                  (xi)     Permitted PharmaBio Investments received in
         connection with a Permitted PharmaBio Swap;

                  (xii)    Permitted Acquisitions for aggregate Acquisition
         Consideration since the Effective Date not to exceed $200.0 million;
         and

                  (xiii)   other loans, advances and investments of the Borrower
         or any Subsidiary Loan Party not in excess of $15.0 million outstanding
         at any time.

                  SECTION 6.05. Asset Sales. The Loan Parties will not, and will
not permit any of their Restricted Subsidiaries to, directly or indirectly,
sell, transfer, lease or otherwise dispose of any asset, including any Equity
Interest owned by them (including Equity Interests of an Unrestricted
Subsidiary), nor will the Borrower permit any of its Subsidiaries (including any
Unrestricted Subsidiaries) to, directly or indirectly, issue any additional
Equity Interest in such Subsidiary, except:

                  (i)      sales of inventory or used, surplus, obsolete,
         outdated, inefficient or worn out equipment and other property in the
         ordinary course of business;

                  (ii)     sales, transfers and dispositions to the Borrower or
         any other Subsidiary Loan Party (other than sales, transfers and
         dispositions to Bioglan); provided that in connection with the
         foregoing, the appropriate Loan Parties shall take all actions
         necessary or reasonably requested by the Collateral Agent to maintain
         the perfection of or perfect, as the case may be, protect and preserve
         the Liens on the Collateral granted to the Collateral Agent pursuant to
         the Security Documents and otherwise comply with the provisions of
         Sections 5.11 and 5.12, in each case, on the terms set forth therein
         and to the extent applicable;

                  (iii)    the lease or sublease of Real Property in the
         ordinary course of business and not constituting a sale and leaseback
         transaction;

                  (iv)     sales of Permitted Investments;

                  (v)      (A) sales of Permitted PharmaBio Investments and (B)
         Permitted PharmaBio Swaps; provided, that, other than with respect to
         sales or swaps of Non-Operating Investments, after giving effect to
         such sale or swap (and any other sale or swap of Permitted PharmaBio
         Investments consummated since the last day of the immediately preceding
         Test Period) on a pro forma basis as if it was consummated on the first
         day of the immediately preceding Test Period (but tested as if the
         applicable ratio were the ratio for the

                                      -104-

<PAGE>

         next succeeding Test Period), the Borrower would be in compliance with
         Sections 6.13 through 6.16, inclusive;

                  (vi)     transfers of assets which transfers constitute
         Investments that are permitted under Section 6.04;

                  (vii)    the issuance by any Designated Asian Subsidiary of
         its Equity Interests in connection with a public offering of Equity
         Interests or sale of Equity Interests to a strategic or an
         institutional investor, in each case for fair value; provided that (i)
         no such issuance shall result in the Borrower or any Restricted
         Subsidiary owning less than 65% of the outstanding Equity Interests on
         a fully diluted basis of such Designated Asian Subsidiary and (ii) the
         net proceeds from such issuance are either (A) retained by such
         Designated Asian Subsidiary and reinvested in its business or (B)
         applied toward the prepayment of Loans to the extent required by
         Section 2.06(c)(iii); provided, however, for purposes of this clause
         (B) only, all references to 270 days in Section 2.06(c) shall be deemed
         to refer to the date that is the earlier of (y) 270 days after the
         repatriation to the Borrower or any Subsidiary Loan Party of the net
         proceeds from such issuance and (z) 540 days following the date of such
         issuance;

                  (viii)   sales, transfers and dispositions of assets between
         Wholly Owned Non-U.S. Subsidiaries;

                  (ix)     sales, transfers and dispositions of assets as
         contemplated by Section 6.01(a)(ix)(1) hereof; and

                  (x)      sales, transfers and dispositions of assets (other
         than Equity Interests of a Restricted Subsidiary) not otherwise
         permitted under this Section; provided that the aggregate fair market
         value of all assets sold, transferred or otherwise disposed of in
         reliance upon this clause (x) shall not, in the aggregate, exceed $35.0
         million during any Fiscal Year and $100.0 million in the aggregate and
         the Net Proceeds thereof are applied as required by Section
         2.06(c)(iii);

provided that all sales, transfers, leases and other dispositions permitted
hereby shall be made for fair value and (x) for at least 75% cash consideration
in the case of sales, transfers, leases and other dispositions permitted by
clause (v)(A) and (y) for 100% cash consideration in the case of sales,
transfers, leases and other dispositions permitted by clauses (iv), (vii), and
(x).

                  SECTION 6.06. Sale and Leaseback Transactions. The Loan
Parties will not, and will not permit any of their Restricted Subsidiaries to,
directly or indirectly, enter into any arrangement, directly or indirectly,
whereby they shall sell or transfer any Property, real or personal, used or
useful in their business, whether now owned or hereafter acquired, and
thereafter rent or lease such Property or other Property that they intend to use
for substantially the same purpose or purposes as the Property sold or
transferred unless (i) the sale of such Property is permitted by Section 6.05
and (ii) any Lien arising in connection with the use of such Property by any
Loan Party or a Restricted Subsidiary is permitted by Section 6.02.

                                      -105-

<PAGE>

                  SECTION 6.07. Restricted Payments. The Parent, the
Intermediate Parent and the Borrower will not, and will not permit any
Restricted Subsidiary to, directly or indirectly, declare or make, or agree to
pay or make, directly or indirectly, any Restricted Payment, or incur any
obligation (contingent or otherwise) to do so, except:

                  (i)      Subsidiaries of the Borrower may declare and pay
         dividends to the Borrower or another Subsidiary ratably with respect to
         their Equity Interests;

                  (ii)     the Parent may pay dividends consisting solely of
         shares of its common stock or additional shares of the same class of
         shares on which the dividend is being paid;

                  (iii)    so long as no Default or Event of Default shall have
         occurred and be continuing, the Parent may purchase, redeem or acquire,
         and the Borrower may make payments, directly or indirectly, to the
         Parent in order for it to so purchase, redeem or acquire, any of its
         Equity Interests or Equity Rights from any of its or its Subsidiaries'
         present or former officers or employees upon the death, disability or
         termination of employment of such officer or employee, so long as the
         aggregate amount of payments under this clause (iii) shall not exceed
         $10.0 million in any Fiscal Year and $20.0 million in the aggregate
         since the Effective Date;

                  (iv)     so long as no Default or Event of Default shall have
         occurred and be continuing, payments, directly or indirectly, to the
         Parent to be used by the Parent to make (a) payments pursuant to the
         Management Agreements, upon the Effective Date, in an aggregate amount
         of $20 million (the "Initial Management Payment") and (b) immediately
         after the receipt thereof, additional payments pursuant to the
         Management Agreements, not to exceed in any calendar year the aggregate
         amount of $3.75 million plus an amount equal to the cumulative CPI
         Increase Amount for each calendar year following the Effective Date
         (the "Annual Management Payment");

                  (v)      the Borrower may make payments, directly or
         indirectly, to the Parent in an amount not to exceed $500,000 during
         any Fiscal Year if the proceeds thereof are immediately used by the
         Parent to pay franchise taxes and other fees required to maintain the
         Parent's corporate existence, other taxes and general corporate and
         overhead expenses (including salaries and other compensation of
         employees) incurred by the Parent in the ordinary course of its
         business as a holding company for the Borrower;

                  (vi)     the Borrower may make payments, directly or
         indirectly, to the Parent to be used by the Parent to pay consolidated,
         combined or similar Federal, state and local taxes payable by the
         Parent and directly attributable to (or arising as a result of) the
         operations of the Borrower and its Subsidiaries; provided, however,
         that (A) the amount of such dividends, distributions or advances paid
         shall not exceed the amount that would be due with respect to a
         consolidated, combined or similar Federal, state or local tax return
         that included the Borrower and its Subsidiaries and (B) such payments
         pursuant to this clause (vi) are used by the Parent for such purposes
         within 90 days of the receipt of such payments;

                                      -106-

<PAGE>

                  (vii)    the Borrower may make Restricted Payments, directly
         or indirectly, to the Intermediate Parent or the Parent pursuant to
         this clause (vii) in an amount not to exceed the sum of (A) $100.0
         million and (B) Cumulative Consolidated Net Income since the Effective
         Date so long as (x) both before and after giving effect thereto, no
         Default or Event of Default has occurred and is continuing and (y) the
         Total Leverage Ratio as of the Test Period ending on the last day for
         which financial statements have been delivered to the Lenders pursuant
         to Section 5.01(a) or (b) on a pro forma basis for such Restricted
         Payment is less than 2.80x;

                  (viii)   the Borrower may make payments, directly or
         indirectly to the Parent to pay fees and expenses pursuant to the Fee
         Agreement, the Subscription Agreements and the DG Equity Rollover
         Agreement each as in effect on the Effective Date as well as in
         connection with the Transactions that have not been otherwise paid by
         the Borrower or Parent; provided that the aggregate amount of payments
         pursuant to this clause (viii) and pursuant to clause (iv)(a) of this
         Section 6.07 shall not exceed $140.0 million; and

                  (ix)     so long as no Default or Event of Default has
         occurred and is continuing, the Intermediate Parent may make payments
         to the Parent on the date of issuance of any Permitted Discount Notes
         or within 60 days thereafter, of the net proceeds from the sale of such
         Permitted Discount Notes to be utilized by the Parent to redeem Series
         A Preferred Stock.

                  SECTION 6.08. Transactions with Affiliates. The Loan Parties
will not, and will not permit any of their Restricted Subsidiaries to, directly
or indirectly, sell, lease or otherwise transfer any property or assets to, or
purchase, lease or otherwise acquire any property or assets from, or otherwise
engage in any other transactions with, any of their Affiliates, unless such
transactions are (i) either (A) in the ordinary course of the Borrower's
business or (B) approved by a majority of those members of the board of
directors of the Parent that are disinterested in the relevant transactions, and
(ii) are at prices and on terms and conditions not less favorable to the Loan
Party or such Restricted Subsidiary than could be obtained on an arm's-length
basis from unrelated third parties, except:

                  (i)      transactions between or among the Borrower and the
         Subsidiary Loan Parties not involving any other Affiliate and
         transactions among Subsidiaries not involving any Loan Party;

                  (ii)     any Restricted Payment permitted by Section 6.07 or
         any Investment (other than Permitted Acquisitions) permitted by Section
         6.04;

                  (iii)    fees and compensation, benefits and incentive
         arrangements paid or provided to, and any indemnity provided on behalf
         of, officers, directors or employees of the Borrower or any Subsidiary
         as determined in good faith by the board of directors of the Borrower;

                  (iv)     loans and advances to employees permitted by Section
         6.04(ix);

                                      -107-

<PAGE>

                  (v)      (a) the Initial Management Payment and (b) so long as
         no Default or Event of Default has occurred and is continuing, the
         Annual Management Payment;

                  (vi)     any tax sharing arrangement and payments pursuant
         thereto among the Borrower and its Restricted Subsidiaries and other
         Persons (including the Parent) with which the Borrower or its
         Restricted Subsidiaries are required or permitted to file a
         consolidated, combined or similar tax return or with which the Borrower
         or any of its Restricted Subsidiaries is or could be a part of a
         consolidated, combined or similar group for tax purposes in amounts not
         otherwise prohibited by this Agreement;

                  (vii)    transactions between the Borrower and Dr. Gillings or
         his Affiliates identified on Schedule 6.08;

                  (viii)   any change of control or severance payments made to
         employees of the Borrower as a result of the Merger pursuant to
         agreements identified on Schedule 6.01(a)(xx) as in effect on the
         Effective Date;

                  (ix)     the issuance or sale of any Equity Interests of the
         Parent; and

                  (x)      payments pursuant to the Fee Agreement, the
         Subscription Agreements and the DG Equity Rollover Agreement, each as
         in effect on the Effective Date.

                  SECTION 6.09. Restrictive Agreements. The Loan Parties will
not, and will not permit any Restricted Subsidiary to, directly or indirectly,
enter into, incur or permit to exist any agreement or other arrangement that
prohibits, restricts or imposes any condition upon (a) the ability of any Loan
Party or any Restricted Subsidiary to create, incur or permit to exist any Lien
upon any of its Property or assets, or (b) the ability of any Restricted
Subsidiary to pay dividends or other distributions with respect to any of its
Equity Interests or to make or repay loans or advances to the Borrower or any
other Restricted Subsidiary or to Guarantee Indebtedness of the Borrower or any
other Restricted Subsidiary or to transfer property to the Borrower or any of
its Restricted Subsidiaries; provided that the foregoing shall not apply to:

                  (i)      conditions imposed by law or any Loan Document;

                  (ii)     clause (a) shall not apply to assets encumbered by
         Permitted Liens as long as such restriction applies only to the asset
         encumbered by such Permitted Lien;

                  (iii)    restrictions and conditions existing on the Effective
         Date not otherwise excepted from this Section 6.09 identified on
         Schedule 6.09 (but shall not apply to any amendment or modification
         expanding the scope of any such restriction or condition);

                  (iv)     any agreement in effect at the time any Person
         becomes a Restricted Subsidiary of the Borrower; provided that such
         agreement was not entered into in contemplation of such Person becoming
         a Restricted Subsidiary;

                                      -108-

<PAGE>

                  (v)      customary restrictions and conditions contained in
         agreements relating to the sale of a Subsidiary (or the assets of a
         Subsidiary) pending such sale, provided such restrictions and
         conditions apply only to the Subsidiary that is to be sold (or whose
         assets are to be sold) and such sale is permitted hereunder;

                  (vi)     clause (a) shall not apply to Indebtedness of
         Non-U.S. Subsidiaries permitted by Section 6.01(a)(vii) so long as such
         Indebtedness does not restrict any Lien securing any of the Loan
         Documents;

                  (vii)    clause (b) shall not apply to Indebtedness of
         Non-U.S. Subsidiaries permitted by Section 6.01(a)(vii) which
         restrictions only apply to such Non-U.S. Subsidiaries and such
         encumbrances or restrictions will not materially affect the Borrower's
         ability to make any principal or interest payment on the Loans; and

                  (viii)   clause (a) shall not apply to customary provisions in
         leases and service contracts in the ordinary course between the
         Borrower and its customers and other contracts restricting the
         assignment thereof.

                  SECTION 6.10. Amendments or Waivers of Certain Documents;
Prepayments of Indebtedness. (a) The Loan Parties will not, and will not permit
any Subsidiary to, directly or indirectly, amend or otherwise change (or waive)
the terms of their Organic Documents, the documents governing any Indebtedness
outstanding as of the date hereof, the Subordinated Notes, the Subordinated
Notes Indenture, any documents governing Permitted Discount Notes or Permitted
Subordinated Indebtedness, the Management Agreements, the Fee Agreement or the
Merger Agreement, in each case, in a manner adverse to the Lenders.

                  (b)      The Loan Parties will not, and will not permit any
Restricted Subsidiary to, make (or give any notice or offer in respect of) any
voluntary or optional payment or mandatory prepayment or redemption or
acquisition for value of (including, without limitation, by way of depositing
with any trustee with respect thereto money or securities before such
Indebtedness is due for the purpose of paying such Indebtedness when due) or
exchange of principal of any Indebtedness of the type referred to in Section
6.01(a)(ii) (except with the net proceeds of Permitted Subordinated Indebtedness
as set forth in Section 6.01(a)(ii)) (xvi) or (xxii).

                  SECTION 6.11. No Other "Designated Senior Indebtedness".
Neither the Parent Guarantors nor the Borrower shall designate, or permit the
designation of, any Indebtedness (other than under this Agreement or the other
Loan Documents) as "Designated Senior Indebtedness" (or any equivalent term)
under the Subordinated Notes Documents or any documents relating to Permitted
Subordinated Indebtedness.

                  SECTION 6.12. Limitation on Activities of Parent Guarantors.
Notwithstanding anything to the contrary set forth herein, neither the Parent
nor the Intermediate Parent shall conduct any business or hold or acquire any
assets (other than the Equity Interests of the Borrower or the net proceeds of
the Permitted Discount Notes to the extent permitted by Section 6.01(a)(xxii),
in the case of the Intermediate Parent, or the Intermediate Parent, in the case
of the

                                      -109-
<PAGE>

Parent) and shall have no operations other than holding such Equity
Interests or such net proceeds, as applicable.

                  SECTION 6.13. Interest Expense Coverage Ratio. The Borrower
will not permit the Interest Expense Coverage Ratio for any Test Period ending
on a date set forth below to be less than the ratio set forth below opposite
such period:

<TABLE>
<CAPTION>
   Test Period                   Ratio
   ----------                    -----
<S>                              <C>
December 31, 2003                2.50
March 31, 2004                   2.50
June 30, 2004                    2.50
September 30, 2004               2.50
December 31, 2004                2.50
March 31, 2005                   3.00
June 30, 2005                    3.00
September 30, 2005               3.00
December 31, 2005                3.00
March 31, 2006                   4.00
June 30, 2006                    4.00
September 30, 2006               4.00
December 31, 2006                4.00
March 31, 2007                   4.00
June 30, 2007                    4.00
September 30, 2007               4.00
December 31, 2007                4.00
March 31, 2008                   4.00
June 30, 2008                    4.00
September 30, 2008               4.00
December 31, 2008                4.00
March 31, 2009                   4.00
June 30, 2009                    4.00
September 30, 2009               4.00
December 31, 2009                4.00
</TABLE>

                  SECTION 6.14. Total Leverage Ratio. The Borrower will not
permit the Total Leverage Ratio for any Test Period ending on a date set forth
below to exceed the ratio set forth opposite such period:

<TABLE>
<CAPTION>
   Test Period                   Ratio
   -----------                   -----
<S>                              <C>
December 31, 2003                 4.50
March 31, 2004                    4.50
June 30, 2004                     4.50
September 30, 2004                4.50
</TABLE>

                                     -110-

<PAGE>

<TABLE>
<CAPTION>
   Test Period                   Ratio
   -----------                   -----
<S>                              <C>
December 31, 2004                 4.50
March 31, 2005                    3.75
June 30, 2005                     3.75
September 30, 2005                3.75
December 31, 2005                 3.75
March 31, 2006                    3.25
June 30, 2006                     3.25
September 30, 2006                3.25
December 31, 2006                 3.25
March 31, 2007                    2.75
June 30, 2007                     2.75
September 30, 2007                2.75
December 31, 2007                 2.75
March 31, 2008                    2.50
June 30, 2008                     2.50
September 30, 2008                2.50
December 31, 2008                 2.50
March 31, 2009                    2.50
June 30, 2009                     2.50
September 30, 2009                2.50
December 31, 2009                 2.50
</TABLE>

                  SECTION 6.15. Senior Leverage Ratio. The Borrower will not
permit the Senior Leverage Ratio for any Test Period ending on a date set forth
below to exceed the ratio set forth opposite such period:

<TABLE>
<CAPTION>
   Test Period                   Ratio
   -----------                   -----
<S>                              <C>
December 31, 2003                 2.25
March 31, 2004                    2.25
June 30, 2004                     2.25
September 30, 2004                2.25
December 31, 2004                 2.25
March 31, 2005                    2.00
June 30, 2005                     2.00
September 30, 2005                2.00
December 31, 2005                 2.00
March 31, 2006                    1.75
June 30, 2006                     1.75
September 30, 2006                1.75
December 31, 2006                 1.75
March 31, 2007                    1.75
</TABLE>

                                     -111-

<PAGE>

<TABLE>
<CAPTION>
   Test Period                   Ratio
   -----------                   -----
<S>                              <C>
June 30, 2007                     1.75
September 30, 2007                1.75
December 31, 2007                 1.75
March 31, 2008                    1.75
June 30, 2008                     1.75
September 30, 2008                1.75
December 31, 2008                 1.75
March 31, 2009                    1.75
June 30, 2009                     1.75
September 30, 2009                1.75
December 31, 2009                 1.75
</TABLE>

                  SECTION 6.16. Capital Expenditures. The Borrower will not, and
will not permit any of its Subsidiaries to, make or commit to make any Capital
Expenditures, except that the Borrower and its Subsidiaries may make or commit
to make Capital Expenditures not exceeding the amount set forth below (the "Base
Amount") for each of the Fiscal Years of the Borrower set forth below:

<TABLE>
<CAPTION>
     Period                       Base Amount
     ------                       -----------
<S>                              <C>
December 31, 2003                $  90,000,000
December 31, 2004                   95,000,000
December 31, 2005                  110,000,000
December 31, 2006                  125,000,000
December 31, 2007                  135,000,000
December 31, 2008                  155,000,000
December 31, 2009                  155,000,000
</TABLE>

provided that for any period set forth above, the Base Amount set forth above
may be increased by a maximum of 50% of the Base Amount for any such period by
carrying over to any such period any portion of the Base Amount (without giving
effect to any increase) not spent in the immediately preceding period, and that
Capital Expenditures in any period shall be deemed first made from the Base
Amount applicable to such period in any given period; provided, further, that
for avoidance of doubt, Capital Expenditures for the Fiscal Year ended December
31, 2003 shall include Capital Expenditures made or committed to be made by the
Borrower prior to the Effective Date.

                  SECTION 6.17. Maintenance of Corporate Separateness. The Loan
Parties shall not permit any Unrestricted Subsidiary to (a) fail to satisfy
customary corporate formalities, including (i) the holding of regular board of
directors' and shareholders' meetings, (ii) the maintenance of separate
corporate records and (iii) the maintenance of separate bank accounts in its own
name; (b) fail to act solely in its own corporate name and through its
authorized officers and agents; (c) commingle any of its money or other assets
with any money or other assets of any Loan Party; or (d) take any action, or
conduct its affairs in a manner which is reasonably likely to

                                      -112-

<PAGE>

result in the separate corporate existence of the Loan Parties from the
Unrestricted Subsidiaries to be ignored or the assets and liabilities of any
Unrestricted Subsidiary being substantively consolidated with those of any Loan
Party in any bankruptcy, insolvency proceeding; or permit any Loan Party to make
any payment to any creditor of any Unrestricted Subsidiary or provide any direct
or indirect guarantee or other credit support for any Indebtedness or other
obligations of any Unrestricted Subsidiary.

                  SECTION 6.18. Anti-Terrorism Law. The Loan Parties shall not
(i) conduct any business or engage in making or receiving any contribution of
funds, goods or services to or for the benefit of any Person described in
Section 3.25 above, (ii) deal in, or otherwise engage in any transaction
relating to, any property or interests in property blocked pursuant to the
Executive Order or any other Anti-Terrorism Law, or (iii) engage in or conspire
to engage in any transaction that evades or avoids, or has the purpose of
evading or avoiding, or attempts to violate, any of the prohibitions set forth
in any Anti-Terrorism Law (and the Loan Parties shall deliver to the Lenders any
certification or other evidence requested from time to time by any Lender in its
reasonable discretion, confirming the Loan Parties' compliance with this Section
6.18).

                  SECTION 6.19. Embargoed Person. At all times throughout the
term of the Loans, (a) none of the funds or assets of the Loan Parties that are
used to repay the Loans shall constitute property of, or shall be beneficially
owned directly or, to the knowledge of any Loan Party, indirectly by, any Person
subject to sanctions or trade restrictions under United States law ("Embargoed
Person" or "Embargoed Persons") that is identified on (1) the "List of Specially
Designated Nationals and Blocked Persons" (the "SDN List") maintained by the
Office of Foreign Assets Control (OFAC), U.S. Department of the Treasury, and/or
to the knowledge of any Loan Party, as of the date thereof, based upon
reasonable inquiry by such Loan Party, on any other similar list ("Other List")
maintained by OFAC pursuant to any authorizing statute including, but not
limited to, the International Emergency Economic Powers Act, 50 U.S.C. Sections
1701 et seq., The Trading with the Enemy Act, 50 U.S.C. App. 1 et seq., and any
Executive Order or regulation promulgated thereunder, with the result that the
investment in the Loan Parties (whether directly or indirectly) is prohibited by
law, or the Loans made by the Lenders would be in violation of law, or (2) the
Executive Order, any related enabling legislation or any other similar Executive
Orders (collectively, "Executive Orders"), and (b) no Embargoed Person shall
have any direct interest, and to the knowledge of any Loan Party, as of the date
hereof, based upon reasonable inquiry by any Loan Party, indirect interest, of
any nature whatsoever in the Loan Parties, with the result that the investment
in the Loan Parties (whether directly or indirectly) is prohibited by law or the
Loans are in violation of law.

                  SECTION 6.20. Anti-Money Laundering. At all times throughout
the term of the Loans, to the knowledge of any Loan Party, as of the date
hereof, based upon reasonable inquiry by such Loan Party, none of the funds of
such Loan Party that are used to repay the Loans shall be derived from any
unlawful activity with the result that the investment in the Loan Parties
(whether directly or indirectly), is prohibited by law or the Loans would be in
violation of law.

                                      -113-

<PAGE>

                                  ARTICLE VII

                                EVENTS OF DEFAULT

                  SECTION 7.01. Listing of Events of Default. Each of the
following events or occurrences described in this Section 7.01 shall constitute
(i) an "Event of Default", if any Loans, LC Disbursements or Letters of Credit
are outstanding, and (ii) an "Event of Termination", if no Loans, LC
Disbursements or Letters of Credit are outstanding:

                  (a)      The Borrower shall default (i) in the payment when
         due of any principal of any Loan (including, without limitation, on any
         Installment Payment Date) or any reimbursement obligation in respect of
         any LC Disbursement, (ii) in the payment when due of any interest on
         any Loan (and such default shall continue unremedied for a period of
         three Business Days), or (iii) in the payment when due of any Fee
         described in Section 2.11 or of any other previously invoiced amount
         (other than an amount described in clauses (i) and (ii)) payable under
         this Agreement or any other Loan Document (and such default shall
         continue unremedied for a period of three Business Days).

                  (b)      Any representation or warranty of the Borrower, the
         Parent Guarantors or any other Loan Party made or deemed to be made
         hereunder or in any other Loan Document or any other writing or
         certificate furnished by or on behalf of the Parent Guarantors or any
         other Loan Party to the Administrative Agent, the Issuing Bank or any
         Lender for the purposes of or in connection with this Agreement or any
         such other Loan Document is or shall be incorrect in any material
         respect when made or deemed made.

                  (c)      The Borrower shall default in the due performance and
         observance of any of its obligations under clause (g), (h) or (l) of
         Section 5.01, clause (a) of Section 5.02 (with respect to the
         maintenance and preservation of the Parent Guarantors' or the
         Borrower's corporate existence) or Article VI.

                  (d)      The Borrower, the Parent Guarantors or any other Loan
         Party shall default in the due performance and observance of any
         agreement (other than those specified in paragraphs (a) through (c)
         above) contained herein or in any other Loan Document, and such default
         shall continue unremedied for a period of 30 days after the date of
         such default.

                  (e)      A default shall occur (i) in the payment when due
         (subject to any applicable grace period), whether by acceleration or
         otherwise, of any Material Indebtedness or (ii) in the performance or
         observance of any obligation or condition with respect to any Material
         Indebtedness if the effect of such default referred to in this clause
         (ii) is to accelerate the maturity of any such Material Indebtedness or
         that enables or permits (with or without the giving of notice, the
         lapse of time or both) the holder or holders of any such Material
         Indebtedness or any trustee or agent on its or their behalf to cause
         any such Material Indebtedness to become due, or to require the
         prepayment, repurchase, redemption or defeasance thereof, prior to its
         scheduled maturity.

                                      -114-

<PAGE>

                  (f)      Any judgment or order (or combination of judgments
         and orders) for the payment of money equal to or in excess of $10.0
         million individually or in the aggregate (to the extent not fully
         covered by insurance (less any deductible) and as to which the insurer
         has acknowledged responsibility to pay such judgment or order) shall be
         rendered against the Borrower, either Parent Guarantor or any of their
         Subsidiaries (or any combination thereof) and

                           (i)      enforcement proceedings shall have been
                  commenced by any creditor upon such judgment or order and not
                  stayed;

                           (ii)     such judgment has not been stayed, vacated
                  or discharged within 60 days of entry; or

                           (iii)    there shall be any period (after any
                  applicable statutory grace period) of 10 consecutive days
                  during which a stay of enforcement of such judgment or order,
                  by reason of a pending appeal or otherwise, shall not be in
                  effect and such judgment is not fully insured against by a
                  policy or policies of insurance (with reasonable or standard
                  deductible provisions) issued by an insurer other than an
                  Affiliate of the Borrower.

                  (g)      Any of the following events shall occur with respect
         to any Pension Plan:

                           (i)      the taking of any specific actions by a Loan
                  Party, any ERISA Affiliate or any other Person to terminate a
                  Pension Plan if, as a result of such termination, a Loan Party
                  or any ERISA Affiliate could expect to incur a liability or
                  obligation to such Pension Plan which could reasonably be
                  expected to have a Material Adverse Effect; or

                           (ii)     an ERISA Event, or event of noncompliance
                  with respect to Foreign Plans, shall have occurred that gives
                  rise to a Lien on the assets of any Loan Party or a Subsidiary
                  or, when taken together with all other ERISA Events and events
                  of noncompliance with respect to Foreign Plans that have
                  occurred, could reasonably be expected to have a Material
                  Adverse Effect.

                  (h)      Any Change in Control shall occur.

                  (i)      The Borrower, either Parent Guarantor or any of their
         Subsidiaries shall

                           (i)      become insolvent or generally fail to pay
                  debts as they become due;

                           (ii)     apply for, consent to or acquiesce in the
                  appointment of a trustee, receiver, sequestrator or other
                  custodian for the Borrower, such Parent Guarantor or any of
                  such Subsidiaries or substantially all of the property of any
                  thereof, or make a general assignment for the benefit of
                  creditors;

                                      -115-
<PAGE>

                           (iii)    in the absence of such application, consent
                  or acquiescence, permit or suffer to exist the appointment of
                  a trustee, receiver, sequestrator or other custodian for the
                  Borrower, such Parent Guarantor or any of such Subsidiaries or
                  for a substantial part of the property of any thereof, and
                  such trustee, receiver, sequestrator or other custodian shall
                  not be discharged or stayed within 60 days, provided that the
                  Borrower, each Parent Guarantor and each such Subsidiary
                  hereby expressly authorizes the Administrative Agent and each
                  Lender to appear in any court conducting any relevant
                  proceeding during such 60-day period to preserve, protect and
                  defend their rights under the Loan Documents;

                           (iv)     permit or suffer to exist the commencement
                  of any bankruptcy, reorganization, debt arrangement or other
                  case or proceeding under any bankruptcy or insolvency law, or
                  any dissolution, winding up or liquidation proceeding, in
                  respect of the Borrower, such Parent Guarantor or any such
                  Subsidiary and, if any such case or proceeding is not
                  commenced by the Borrower, such Parent Guarantor or such
                  Subsidiary, such case or proceeding shall be consented to or
                  acquiesced in by the Borrower, such Parent Guarantor or such
                  Subsidiary or shall result in the entry of an order for relief
                  or shall remain for 60 days undismissed and unstayed, provided
                  that the Borrower, each Parent Guarantor and each such
                  Subsidiary hereby expressly authorizes the Administrative
                  Agent and each Lender to appear in any court conducting any
                  such case or proceeding during such 60-day period to preserve,
                  protect and defend their rights under the Loan Documents; or

                           (v)      take any corporate or partnership action (or
                  comparable action, in the case of any other form of legal
                  entity) authorizing, or in furtherance of, any of the
                  foregoing.

                  (j)      The obligations of either Parent Guarantor under its
         Guarantee in Article IX or of any other Loan Party under the Guarantee
         Agreement shall cease to be in full force and effect or either Parent
         Guarantor or any such other Loan Party shall repudiate its obligations
         thereunder.

                  (k)      Any Lien purported to be created under any Security
         Document shall fail or cease to be (other than any Lien which is
         voluntarily released by the Collateral Agent), or shall be asserted by
         any Loan Party not to be, a valid and perfected Lien on any Collateral,
         with the priority required by the applicable Security Document, and
         such failure or cessation shall continue unremedied for five days.

                  (l)      The subordination provisions relating to the
         Subordinated Notes or any Permitted Subordinated Indebtedness (the
         "Subordination Provisions") shall fail in any material respect to be
         enforceable by the Lenders (which have not effectively waived the
         benefits thereof) in accordance with the terms thereof or the Borrower,
         the Parent Guarantors or any Subsidiary Loan Party shall, directly or
         indirectly, disavow or contest in any manner any of the Subordination
         Provisions.

                                     -116-

<PAGE>

                  SECTION 7.02. Action if Bankruptcy. If any Event of Default
described in clauses (i) through (v) of Section 7.01(i) shall occur, the
Commitments (if not theretofore terminated) shall automatically terminate and
the outstanding principal amount of all outstanding Loans and all other
Obligations shall automatically be and become immediately due and payable,
without notice or demand, all of which are hereby waived by the Borrower.

                  SECTION 7.03. Action if Other Event of Default. If any Event
of Default (other than any Event of Default described in clauses (i) through (v)
of Section 7.01(i)) shall occur for any reason, whether voluntary or
involuntary, and be continuing, the Administrative Agent, upon the direction of
the Requisite Lenders, shall by written notice to the Borrower and each Lender
declare all or any portion of the outstanding principal amount of the Loans and
other Obligations to be due and payable and/or the Commitments (if not
theretofore terminated) to be terminated, whereupon the full unpaid amount of
such Loans and other Obligations which shall be so declared due and payable
shall be and become immediately due and payable, without further notice, demand
or presentment and/or, as the case may be, the Commitments shall terminate.

                  SECTION 7.04. Action if Event of Termination. Upon the
occurrence and continuation of any Event of Termination, the Requisite Lenders
may, by notice from the Administrative Agent to the Borrower and the Lenders
(except if an Event of Termination described in clauses (i) through (v) of
Section 7.01(i) shall have occurred, in which case the Commitments (if not
theretofore terminated) shall, without notice of any kind, automatically
terminate) declare their Commitments terminated, and upon such declaration the
Lenders shall have no further obligation to make any Loans hereunder. Upon such
termination of the Commitments, all accrued fees and expenses shall be
immediately due and payable.

                                  ARTICLE VIII

                                   THE AGENTS

                  SECTION 8.01. The Agents. Citicorp North America, Inc. is
hereby appointed to act as Administrative Agent and Collateral Agent on behalf
of the Lenders. Each of the Lenders and each assignee of any such Lender hereby
irrevocably authorizes each of the Agents to take such actions on behalf of such
Lender or assignee and to exercise such powers as are specifically delegated to
such Agent by the terms and provisions hereof and of the other Loan Documents,
together with such actions and powers as are reasonably incidental thereto. Each
Agent is hereby expressly authorized by the Lenders, without hereby limiting any
implied authority, (a) to receive on behalf of the Lenders all payments of
principal of and interest on the Loans, all payments and all other amounts due
to the Lenders hereunder, and promptly to distribute to each Lender its proper
share of each payment so received; (b) to give notice on behalf of each of the
Lenders to the Borrower of any Default specified in this Agreement of which such
Agent has actual knowledge acquired in connection with its agency hereunder; (c)
to distribute to each Lender copies of all notices, financial statements and
other materials delivered by the Borrower pursuant to this Agreement as received
by such Agent, (d) to enter into the Security Documents on behalf of the Lenders
and (e) to claim all Obligations owed to any Lender against the Borrower in its
own name for the purpose of any Security Documents.

                                     -117-

<PAGE>

                  None of the Agents nor any of their Related Parties shall be
liable to the Lenders as such for any action taken or omitted to be taken by any
of them except to the extent finally judicially determined to have resulted from
its or his or her own gross negligence or willful misconduct, or be responsible
for any statement, warranty or representation herein or the contents of any
document delivered in connection herewith, or be required to ascertain or to
make any inquiry concerning the performance or observance by any Loan Party of
any of the terms, conditions, covenants or agreements contained in any Loan
Document. The Agents shall not be responsible to the Lenders for the due
execution, genuineness, validity, enforceability or effectiveness of this
Agreement or any other Loan Documents or other instruments or agreements. Each
Agent shall in all cases be fully protected in acting, or refraining from
acting, in accordance with written instructions signed by the Requisite Lenders
(or, when expressly required hereby, all the Lenders) and, except as otherwise
specifically provided herein, such instructions and any action or inaction
pursuant thereto shall be binding on all the Lenders. Each Agent shall, in the
absence of actual knowledge to the contrary, be entitled to rely on any
instrument or document believed by it in good faith to be genuine and correct
and to have been signed or sent by the proper person or persons. None of the
Agents nor any of their Related Parties shall have any responsibility to the
Loan Parties on account of the failure of or delay in performance or breach by
any Lender of any of its obligations hereunder or to any Lender on account of
the failure of or delay in performance or breach by any other Lender or the Loan
Parties of any of their respective obligations hereunder or under any other Loan
Document or in connection herewith or therewith. Each Agent may execute any and
all duties hereunder by or through any of its Related Parties or any sub-agent
appointed by it and shall be entitled to rely upon the advice of legal counsel
selected by it with respect to all matters arising hereunder and shall not be
liable for any action taken or suffered in good faith by it in accordance with
the advice of such counsel.

                  The Lenders hereby acknowledge that no Agent shall be under
any duty to take any discretionary action permitted to be taken by it pursuant
to the provisions of any Loan Document unless it shall be requested in writing
to do so by the Requisite Lenders.

                  Subject to the appointment and acceptance of a successor Agent
as provided below, any Agent may resign at any time by notifying the Lenders,
the Issuing Bank and the Borrower. Upon any such resignation, the Requisite
Lenders shall have the right to appoint a successor. If no successor shall have
been so appointed by the Requisite Lenders and shall have accepted such
appointment within 30 days after the retiring Agent gives notice of its
resignation, then the retiring Agent may, on behalf of the Lenders and the
Issuing Bank, appoint a successor Agent which shall be a bank with an office in
New York, New York, having a combined capital and surplus of at least $500.0
million or an Affiliate of any such bank. Upon the acceptance of any appointment
as an Agent hereunder by such a successor bank, such successor shall succeed to
and become vested with all the rights, powers, privileges and duties of the
retiring Agent and the retiring Agent shall be discharged from its duties and
obligations hereunder. After an Agent's resignation hereunder, the provisions of
this Article and Section 10.05 shall continue in effect for its benefit in
respect of any actions taken or omitted to be taken by it while it was acting as
an Agent.

                                     -118-

<PAGE>

                  With respect to the Loans made by it hereunder, each Agent in
its individual capacity and not as an Agent shall have the same rights and
powers as any other Lender and may exercise the same as though it were not an
Agent, and such Agent and its Affiliates may accept deposits from, lend money to
and generally engage in any kind of business with the Borrower or any Subsidiary
or other Affiliate thereof as if it were not an Agent.

                  Each Lender acknowledges that it has, independently and
without reliance upon any Agent or any other Lender and based on such documents
and information as it has deemed appropriate, made its own credit analysis and
decision to enter into this Agreement. Each Lender also acknowledges that it
will, independently and without reliance upon any Agent or any other Lender and
based on such documents and information as it shall from time to time deem
appropriate, continue to make its own decisions in taking or not taking action
under or based upon this Agreement or any other Loan Document, any related
agreement or any document furnished hereunder or thereunder.

                  Notwithstanding anything to the contrary in this Agreement,
neither CGMI, as a Lead Arranger, in such capacity, nor CGMI or Banc One, as
Syndication Agents, or RFC, as Documentation Agent, shall have any obligations,
duties or responsibilities, and shall incur any liabilities, under this
Agreement or any other Loan Document.

                                   ARTICLE IX

                                    GUARANTEE

                  SECTION 9.01. Guarantee of the Parent Guarantors. In order to
induce the Administrative Agent, the Issuing Bank and the Lenders to execute and
deliver this Agreement and to make or maintain the Loans and to issue Letters of
Credit hereunder, and in consideration thereof, each of the Parent Guarantors
hereby unconditionally and irrevocably guarantees, as primary obligor and not
merely as surety, to the Agents, for the ratable benefit of the Secured Parties,
the prompt and complete payment and performance by the Borrower when due
(whether at stated maturity, by acceleration or otherwise) of the Obligations,
and each of the Parent Guarantors further agrees to pay any and all reasonable
expenses (including, without limitation, all reasonable fees, charges and
disbursements of counsel) which may be paid or incurred by the Agents, the
Issuing Bank or any Lender in enforcing any of their rights under the Guarantee
contained in this Article IX. The Guarantee contained in this Article IX,
subject to Section 9.04, shall remain in full force and effect until all Letters
of Credit have terminated, the Obligations are paid in full and the Commitments
are terminated.

                  Each of the Parent Guarantors agrees that whenever, at any
time, or from time to time, it shall make any payment to any Agent, the Issuing
Bank or any Lender on account of its liability under this Article IX, it will
notify such Agent, the Issuing Bank or such Lender in writing that such payment
is made under the Guarantee contained in this Article IX for such purpose. No
payment or payments made by the Borrower or any other Person or received or
collected by any Agent, the Issuing Bank or any Lender from the Borrower or any
other Person by virtue of any action or proceeding or any setoff or
appropriation or application, at any time or from time to time, in reduction of
or in payment of the Obligations shall be deemed to modify, reduce, release

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or otherwise affect the liability of such Parent Guarantor under this Article
IX, which, notwithstanding any such payment or payments, shall remain liable for
the unpaid and outstanding Obligations until, subject to Section 9.04, all
Letters of Credit have terminated and the Obligations are paid in full and the
Commitments are terminated.

                  SECTION 9.02. Amendments, etc. with Respect to the Applicable
Obligations. Each of the Parent Guarantors shall remain obligated under this
Article IX notwithstanding that (i) without any reservation of rights against
such Parent Guarantor, and (ii) without notice to or further assent by such
Parent Guarantor, (x) any demand for payment of or reduction in the principal
amount of any of the Obligations made by the Agents, the Syndication Agents, the
Issuing Bank or any Lender may be rescinded by the Agents, the Syndication
Agents, the Issuing Bank or such Lender, (y) any of the Obligations may be
continued, and the applicable Obligations, or the liability of any other party
upon or for any part thereof, or any collateral security or guarantee therefor
or right of offset with respect thereto, may, from time to time, in whole or in
part, be renewed, extended, amended, modified, accelerated, compromised, waived,
surrendered or released by the Agents, the Syndication Agents, the Issuing Bank
or any Lender, and (z) this Agreement and any other documents executed and
delivered in connection herewith may be amended, modified, supplemented or
terminated, in whole or in part, as the Lenders (or the Requisite Lenders, as
the case may be) may deem advisable from time to time, and any collateral
security, guarantee or right of offset at any time held by the Agents, the
Syndication Agents, the Issuing Bank or any Lender for the payment of the
applicable Obligations may be sold, exchanged, waived, surrendered or released.
None of the Agents, the Syndication Agents, the Issuing Bank or any Lender shall
have any obligation to protect, secure, perfect or insure any Lien at any time
held by it as security for the Obligations or for the Guarantee contained in
this Article IX or any property subject thereto.

                  SECTION 9.03. Guarantee Absolute and Unconditional. Each of
the Parent Guarantors waives any and all notice of the creation, renewal,
extension or accrual of any of the Obligations and notice of or proof of
reliance by the Agents, the Syndication Agents, the Issuing Bank or any Lender
upon the Guarantee contained in this Article IX or acceptance of the Guarantee
contained in this Article IX; the Obligations, and any of them, shall
conclusively be deemed to have been created, contracted or incurred, or renewed,
extended, amended or waived, in reliance upon the Guarantee contained in this
Article IX, and all dealings between each of the Parent Guarantors, on the one
hand, and the Agents, the Syndication Agents, the Issuing Bank and the Lenders,
on the other, shall likewise be conclusively presumed to have been had or
consummated in reliance upon the Guarantee contained in this Article IX. The
Agents, Syndication Agents, Issuing Bank and any Lender will, to the extent
permitted by applicable law, request payment of any applicable Obligation from
the Borrower before making any claim against either Parent Guarantor under this
Article IX, but will have no further obligation to proceed against the Borrower
or to defer for any period a claim against each of the Parent Guarantors
hereunder. Except as expressly provided in the preceding sentence, each of the
Parent Guarantors waives diligence, presentment, protest, demand for payment and
notice of default or nonpayment to or upon such Parent Guarantor or the Borrower
with respect to the Obligations. The Guarantee contained in this Article IX
shall be construed as a continuing, absolute and unconditional guarantee of
payment without regard to (a) the validity or enforceability of this Agreement
or any other Loan Document, any of the Obligations or any collateral security

                                     -120-

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therefor or Guarantee or right of offset with respect thereto at any time or
from time to time held by any Agent, the Syndication Agents, the Issuing Bank or
any Lender, (b) the legality under applicable laws of repayment by the Borrower
of any Obligations or the adoption of any applicable laws purporting to render
any Obligations null and void, (c) any defense, setoff or counterclaim (other
than a defense of payment or performance) which may at any time be available to
or be asserted by either Parent Guarantor or the Borrower against the Agents,
the Syndication Agents, the Issuing Bank or any Lender, or (d) any other
circumstance whatsoever (with or without notice to or knowledge of either Parent
Guarantor or the Borrower) which constitutes, or might be construed to
constitute, an equitable or legal discharge of the Borrower for any Obligations,
or of either Parent Guarantor under the Guarantee contained in this Article IX,
in bankruptcy or in any other instance. When any Agent, the Syndication Agents,
the Issuing Bank or any Lender is pursuing its rights and remedies under this
Article IX against the Parent Guarantors, such Agent, the Syndication Agents,
the Issuing Bank or such Lender may, but shall be under no obligation to, pursue
such rights and remedies as it may have against the Borrower or any other Person
or against any collateral security or Guarantee for the Obligations or any right
of offset with respect thereto, and any failure by any Agent, the Syndication
Agents, the Issuing Bank or any Lender to pursue such other rights or remedies
or to collect any payments from the Borrower or any such other Person or to
realize upon any such collateral security or Guarantee or to exercise any such
right of offset, or any release of the Borrower or any such other Person or of
any such collateral security, Guarantee or right of offset, shall not relieve
the Parent Guarantors of any liability under this Article IX, and shall not
impair or affect the rights and remedies, whether express, implied or available
as a matter of law, of the Agents, the Syndication Agents, the Issuing Bank and
the Lenders against the Parent Guarantors.

                  SECTION 9.04. Reinstatement. The Guarantee contained in this
Article IX shall continue to be effective, or be reinstated, as the case may be,
if at any time payment, or any part thereof, of any of the Obligations is
rescinded or must otherwise be restored or returned by any Agent, the
Syndication Agents, the Issuing Bank or any Lender upon the insolvency,
bankruptcy, dissolution, liquidation or reorganization of the Borrower or upon
or as a result of the appointment of a receiver, intervenor or conservator of,
or trustee or similar officer for, the Borrower or any substantial part of its
Property, or otherwise, all as though such payments had not been made.

                  SECTION 9.05. Payments. Each of the Parent Guarantors hereby
agrees that any payments in respect of the Obligations pursuant to this Article
IX will be paid without setoff or counterclaim in the currency in which the
applicable Loans are denominated at the office of the Administrative Agent
specified in Section 10.01.

                  SECTION 9.06. Independent Obligations. The obligations of each
of the Parent Guarantors under the Guarantee contained in this Article IX are
independent of the obligations of the Borrower, and a separate action or actions
may be brought and prosecuted against each of the Parent Guarantors whether or
not the Borrower is joined in any such action or actions. Each of the Parent
Guarantors waives, to the full extent permitted by law, the benefit of any
statute of limitations affecting its liability hereunder or the enforcement
thereof. Any pay-

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<PAGE>

ment by the Borrower or other circumstance which operates to toll any statute of
limitations as to the Borrower shall operate to toll the statute of limitations
as to the Parent Guarantors.

                                   ARTICLE X

                                  MISCELLANEOUS

                  SECTION 10.01. Notices. (a) Except as set forth in Section
10.17, notices and other communications provided for herein shall be in writing
and shall be delivered by hand or overnight courier service, mailed by certified
or registered mail, sent by telecopy or electronic mail, as follows:

                  (i)      if to the Borrower, to it at 4709 Creekstone Drive,
         Riverbirch Building, Suite 200, Durham, NC 27703 (telecopy: (919)
         941-7345) (e-mail: john.russell@quintiles.com), with a copy to Smith,
         Anderson, Blount, Dorsett, Mitchell & Jernigan, L.L.P., 2500 First
         Union Capital Center, P.O. Box 2611, Raleigh, NC 27602, attention:
         Gerald F. Roach, Esq. (telecopy: (919) 821-6800), and a copy to Morgan,
         Lewis & Bockius LLP, 101 Park Avenue, New York, NY 10178, attention:
         Ira White, Esq. (telecopy: (212) 309-6273);

                  (ii)     if to the Administrative Agent to it at Citicorp
         North America, Inc., 390 Greenwich St., New York, New York 10013,
         attention: Allen Fisher (telecopy: (212) 723-6708) (e-mail:
         allen.fisher@citigroup.com), with a copy to Cahill Gordon & Reindel
         LLP, 80 Pine Street, New York, New York 10005, attention: William M.
         Hartnett, Esq. (telecopy: (212) 269-5420);

                  (iii)    if to the Syndication Agents, to ABN at 55 East 52nd
         Street, New York, New York 10055 and to Banc One at 1 Bank One Plaza,
         Mail Code ILI-0868, Chicago, IL 60603;

                  (iv)     if to the Documentation Agent, to RFC at 2711 North
         Haskell, Suite 900, Dallas, Texas 75204;

                  (v)      if to the Issuing Bank, to it at Citicorp North
         America, Inc., 390 Greenwich St., New York, New York 10013, attention:
         Allen Fisher (telecopy: (212) 723-6708) (e-mail:
         allen.fisher@citigroup.com), with a copy to Cahill Gordon & Reindel
         LLP, 80 Pine Street, New York, New York 10005, attention: William M.
         Hartnett, Esq. (telecopy: (212) 269-5420); and

                  (vi)     if to a Lender, to it at its address (or telecopy
         number) set forth in Schedule 2.01 or its Administrative Questionnaire
         or in the Assignment and Acceptance pursuant to which such Lender shall
         have become a party hereto.

                  All notices and other communications given to any party hereto
in accordance with the provisions of this Agreement shall be deemed to have been
given on the date of receipt if delivered by hand or overnight courier service
or sent by telecopy or electronic mail or on the

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<PAGE>

date five Business Days after dispatch by certified or registered mail if
mailed, in each case delivered, sent or mailed (properly addressed) to such
party as provided in this Section 10.01 or in accordance with the latest
unrevoked direction from such party given in accordance with this Section 10.01.
Each Loan Party and Lender hereunder agrees to notify the Administrative Agent
in writing promptly of any change to the notice information provided above or in
Schedule 2.01.

                  (b)      The Borrower shall forthwith on demand indemnify each
Lender against any loss or liability which that Lender incurs (and that Lender
shall not be liable to the Borrower in any respect) as a consequence of:

                  (i)      any Person to whom any notice or communication under
         or in connection with this Agreement is sent by the Borrower by
         telecopy failing to receive that notice or communication (unless
         directly caused by that Person's gross negligence or willful default);
         or

                  (ii)     any telecopy communication which reasonably appears
         to that Lender to have been sent by the Borrower having in fact been
         sent by a Person other than the Borrower.

                  SECTION 10.02. Survival of Agreement. All covenants,
agreements, representations and warranties made by the Loan Parties herein and
in the certificates or other instruments prepared or delivered in connection
with or pursuant to this Agreement or any other Loan Document shall be
considered to have been relied upon by Lenders hereto and shall survive the
making by the Lenders of the Loans and issuance of any Letters of Credit,
regardless of any investigation made by any such other party or on its behalf
and notwithstanding that the Administrative Agent, the Issuing Bank or any
Lender may have had notice or knowledge of any Default or Event of Default or
incorrect representation or warranty at the time any credit is extended
hereunder, and shall continue in full force and effect as long as the principal
of or any accrued interest on any Loan or any Fee or any other amount payable
under this Agreement or any other Loan Document is outstanding and unpaid or any
Letter of Credit is outstanding and so long as the Commitments have not been
terminated. The provisions of Sections 2.16, 2.17, 2.18, 10.05 and 10.16 and
Article VIII shall survive and remain in full force and effect regardless of the
consummation of the transactions contemplated hereby, the repayment of the
Loans, the expiration or termination of the Letters of Credit and the
Commitments or the termination of this Agreement or any provision hereof.

                  SECTION 10.03. Binding Effect. Subject to Section 4.01, this
Agreement shall become effective when it shall have been executed by the
Borrower and the Administrative Agent and when the Administrative Agent shall
have received counterparts hereof which, when taken together, bear the
signatures of each of the other parties hereto, and thereafter shall be binding
upon and inure to the benefit of the parties hereto and their respective
permitted successors and assigns.

                  SECTION 10.04. Successors and Assigns. (a) Whenever in this
Agreement any of the parties hereto is referred to, such reference shall be
deemed to include the permitted successors and assigns of such party (including
any Affiliate of the Issuing Bank that issues any Let-

                                     -123-

<PAGE>

ter of Credit). All covenants, promises and agreements by or on behalf of the
Borrower, the Agents or the Lenders that are contained in this Agreement shall
bind and inure to the benefit of their respective successors and assigns.
Nothing in this Agreement, expressed or implied, shall be construed to confer
upon any Person (other than the parties hereto, their respective successors and
assigns permitted hereby, Participants to the extent provided in clause (f)
below and, solely to the extent expressly contemplated hereby, the Related
Parties of each of the Agents, the Issuing Bank and the Lenders) any legal or
equitable right, remedy or claim under or by reason of this Agreement.

                  (b)      Each Lender may assign to one or more assignees all
or a portion of its interests, rights and obligations under this Agreement
(including all or a portion of its Commitment and the Loans at the time owing to
it); provided, however, that (i) except in the case of an assignment to a Lender
or a Lender Affiliate or in connection with the initial syndication of the
Commitments and Loans, the Borrower and the Administrative Agent (and, in the
case of any assignment of a Revolving Credit Commitment or any Lender's
obligations in respect of its LC Exposure, Swingline Exposure or Foreign
Currency Exposure, the Issuing Bank, the Swingline Lender and the Foreign
Currency Lenders, as applicable) must give their prior written consent to such
assignment (which consent shall not be unreasonably withheld or delayed), (ii)
except in the case of an assignment to a Lender or a Lender Affiliate or in
connection with the initial syndication of the Commitments and Loans, the amount
of the Commitment or Loans of the assigning Lender subject to each such
assignment (determined as of the date the Assignment and Acceptance with respect
to such assignment is delivered to the Administrative Agent) shall not be less
than, in the case of the Term B Loans, $1.0 million and increments of $1.0
million in excess thereof and, in the case of the Revolving Loans, $5.0 million
and increments of $1.0 million in excess thereof (or (A) if the aggregate amount
of the Commitment or Loans of the assigning Lender is a lesser amount, the
entire amount of such Commitment or Loans, or (B) in any other case, such lesser
amount as the Borrower and the Administrative Agent otherwise agree), (iii) each
partial assignment shall be made as an assignment of a proportionate part of all
the assigning Lender's rights and obligations under this Agreement, except that
this clause (iii) shall not be construed to prohibit the assignment of a
proportionate part of all the assigning Lender's rights and obligations in
respect of one Class of Commitments and Loans, (iv) except in the case of the
assignment to a Lender Affiliate of such Lender or an assignment required to be
made pursuant to Section 2.21, the parties to each such assignment shall execute
and deliver to the Administrative Agent an Assignment and Acceptance, together
with a processing and recordation fee of $3,500 and, if applicable, the forms
required by Section 2.17(c) hereof, and (v) the assignee, if it shall not be a
Lender, shall deliver to the Administrative Agent an Administrative
Questionnaire; provided, further, that any consent of the Borrower otherwise
required under this paragraph shall not be required if a Default or an Event of
Default has occurred and is continuing. Subject to acceptance and recording
pursuant to paragraph (e) of this Section 10.04, from and after the effective
date specified in each Assignment and Acceptance, which effective date shall be
at least five Business Days after the execution thereof (unless otherwise
determined by the Administrative Agent), (A) the assignee thereunder shall be a
party hereto and, to the extent of the interest assigned by such Assignment and
Acceptance, have the rights and obligations of a Lender under this Agreement,
and (B) the assigning Lender thereunder shall, to the extent of the interest
assigned by such Assignment and Acceptance, be released from its obligations
under this Agree-

                                     -124-

<PAGE>

ment (and, in the case of an Assignment and Acceptance covering all or the
remaining portion of an assigning Lender's rights and obligations under this
Agreement, such Lender shall cease to be a party hereto but shall continue to be
entitled to the benefits of Sections 2.16, 2.17, 2.18 and 10.05 with respect to
facts and circumstances occurring prior to the effective date of such
assignment, as well as to any Fees accrued for its account and not yet paid).
Any assignment or transfer by a Lender of rights or obligations under this
Agreement that does not comply with this paragraph shall be treated for purposes
of this Agreement as a sale by such Lender of a participation in such rights and
obligations in accordance with paragraph (f) of this Section.

                  (c)      By executing and delivering an Assignment and
Acceptance, the assigning Lender thereunder and the assignee thereunder shall be
deemed to confirm to and agree with each other and the other parties hereto as
follows: (i) such assigning Lender warrants that it is the legal and beneficial
owner of the interest being assigned thereby free and clear of any adverse claim
and that its Commitment, and the outstanding balances of its Loans and
participations in Swingline Loans, in each case without giving effect to
assignments thereof which have not become effective, are as set forth in such
Assignment and Acceptance, (ii) except as set forth in (i) above, such assigning
Lender makes no representation or warranty and assumes no responsibility with
respect to any statements, warranties or representations made in or in
connection with this Agreement, or the execution, legality, validity,
enforceability, genuineness, sufficiency or value of this Agreement, any other
Loan Document or any other instrument or document furnished pursuant hereto, or
the financial condition of the Borrower or any Subsidiary or the performance or
observance by the Borrower or any Subsidiary of any of its obligations under
this Agreement, any other Loan Document or any other instrument or document
furnished pursuant hereto; (iii) such assignee represents and warrants that it
is legally authorized to enter into such Assignment and Acceptance; (iv) such
assignee confirms that it has received a copy of this Agreement, together with
copies of the most recent financial statements, if any, delivered pursuant to
Section 5.01 and such other documents and information as it has deemed
appropriate to make its own credit analysis and decision to enter into such
Assignment and Acceptance; (v) such assignee will independently and without
reliance upon either Agent, such assigning Lender or any other Lender and based
on such documents and information as it shall deem appropriate at the time,
continue to make its own credit decisions in taking or not taking action under
this Agreement; (vi) such assignee appoints and authorizes each Agent to take
such action as agent on its behalf and to exercise such powers under this
Agreement as are delegated to such Agent by the terms hereof and any other Loan
Document, together with such powers as are reasonably incidental thereto; (vii)
such assignee agrees that it will perform in accordance with their terms all the
obligations which by the terms of this Agreement are required to be performed by
it as a Lender; and (viii) Schedule 2.01 shall be deemed to be amended to
reflect the reduction of commitment of or deletion of the assigning Lender
thereunder and the commitment of the assignee thereunder after giving effect
thereto.

                  (d)      The Administrative Agent, acting for this purpose as
an agent of the Borrower, shall maintain at one of its offices in the City of
New York a copy of each Assignment and Acceptance delivered to it and a register
for the recordation of the names and addresses of the Lenders, and the
Commitment of, and principal amount of the Loans and LC Disbursements, and
participations in Swingline Loans, owing to, each Lender pursuant to the terms
hereof from

                                     -125-

<PAGE>

time to time (the "Register"). Except to the extent inconsistent with Section
2.08(d), the entries in the Register shall be conclusive and the Borrower, the
Agents, the Issuing Bank and the Lenders may treat each Person whose name is
recorded in the Register pursuant to the terms hereof as a Lender hereunder for
all purposes of this Agreement, notwithstanding notice to the contrary. The
Register shall be available for inspection by the Borrower, the Issuing Bank and
any Lender, at any reasonable time and from time to time upon reasonable prior
notice.

                  (e)      Upon its receipt of a duly completed Assignment and
Acceptance executed by an assigning Lender and an assignee, an Administrative
Questionnaire completed in respect of the assignee (unless the assignee shall
already be a Lender hereunder), the processing and recordation fee referred to
in paragraph (b) above and, if required, the written consent of the Borrower,
the Issuing Bank, the Swingline Lender, the Foreign Currency Lenders and the
Administrative Agent to such assignment, the Administrative Agent shall (i)
accept such Assignment and Acceptance, (ii) record the information contained
therein in the Register and (iii) give prompt notice thereof to the Lenders. No
assignment shall be effective unless it has been recorded in the Register as
provided in this paragraph (e).

                  (f)      Each Lender may without the consent of the Borrower,
the Swingline Lender, the Foreign Currency Lender, the Issuing Bank or the
Administrative Agent, sell participations to any Person (other than a natural
person or the Borrower or any of the Borrower's Affiliates or Subsidiaries)
(each, a "Participant") in all or a portion of its rights and obligations under
this Agreement (including all or a portion of its Commitment and the Loans owing
to it); provided, however, that (i) such Lender's obligations under this
Agreement shall remain unchanged, (ii) such Lender shall remain solely
responsible to the other parties hereto for the performance of such obligations,
(iii) each Participant shall be entitled to the benefit of the cost protection
provisions contained in Sections 2.16, 2.17 and 2.18 and the provisions of
Section 5.01 to the same extent as if they were Lenders and had acquired its
interest by assignment pursuant to paragraph (b) of this Section 10.04 (provided
that no participant shall be entitled to receive any greater amount pursuant to
such Sections than the Lender would have been entitled to receive in respect of
the interest transferred unless either (x) such transfer to such Participant is
made with the Borrower's prior written consent (not to be unreasonably withheld)
or (y) a Default or an Event of Default has occurred and is continuing at the
time of such participation), and (iv) the Borrower, the Agents, the Issuing Bank
and the Lenders shall continue to deal solely and directly with such Lender in
connection with such Lender's rights and obligations under this Agreement, and
such Lender shall retain the sole right (which each Lender agrees will not be
limited by the terms of any participation agreement or other agreement with a
participant) to enforce the Loan Documents and to approve any amendment,
modification or waiver of any provision of the Loan Documents (other than,
without the consent of the Participant, amendments, modifications or waivers
described in the first proviso of Section 10.08(b) that affect such
Participant). To the extent permitted by law, each Participant also shall be
entitled to the benefits of Section 10.06 as though it were a Lender, provided
such Participant agrees to be subject to Section 2.21 as though it were a
Lender.

                  (g)      Any Lender or participant may, in connection with any
assignment or participation or proposed assignment or participation pursuant to
this Section 10.04, disclose to the

                                     -126-

<PAGE>

assignee or participant or proposed assignee or participant any information
relating to the Borrower and its Subsidiaries furnished to such Lender by or on
behalf of any of the Loan Parties; provided that, prior to any such disclosure
of information designated by the Borrower as confidential, each such assignee or
participant or proposed assignee or participant shall execute a confidentiality
agreement in form and substance consistent with provisions of Section 10.16.

                  (h)      Any Lender may at any time pledge or assign a
security interest in all or any portion of its rights under this Agreement to
secure obligations of such Lender, including any pledge or assignment to secure
obligations to a Federal Reserve Bank and this Section 10.04 shall not apply to
any such pledge or assignment of a security interest; provided that (x) no such
pledge or assignment of a security interest shall release a Lender from any of
its obligations hereunder or substitute any such pledgee or assignee for such
Lender as a party hereto and (y) any foreclosure or similar action shall be
subject to the provisions of Section 10.04(b) concerning assignments and shall
not be effective to transfer any rights under this Agreement or in any Loan,
Note or other instrument evidencing the rights of a Lender under this Agreement
until the requirements of Section 10.04(b) concerning assignments are fully
satisfied. In order to facilitate such a pledge or assignment, the Borrower
shall, at the request of the assigning Lender, duly execute and deliver to the
assigning Lender a promissory note or notes evidencing the Loans made to the
Borrower by the assigning Lender hereunder.

                  (i)      The Borrower shall not assign or delegate any of its
rights or duties hereunder without the prior written consent of the
Administrative Agent and each Lender, and any attempted assignment without such
consent shall be null and void.

                  SECTION 10.05. Expenses; Indemnity. (a) The Loan Parties
agree, jointly and severally, to pay (i) all reasonable out-of-pocket expenses
incurred by the Administrative Agent, the Collateral Agent, CGMI and its
Affiliates, including the reasonable fees, charges and disbursements of Cahill
Gordon & Reindel LLP, counsel for the Administrative Agent, in connection with
the syndication of the credit facilities provided for herein, the preparation
and administration of this Agreement and the other Loan Documents or in
connection with any amendments, modifications or waivers of the provisions
hereof or thereof (whether or not the transactions hereby contemplated shall be
consummated), (ii) all reasonable out-of-pocket expenses incurred by the Issuing
Bank in connection with the issuance, amendment, renewal or extension of any
Letter of Credit or any demand for payment thereunder and (iii) all reasonable
out-of-pocket expenses incurred by the Lead Arranger, the Administrative Agent,
the Collateral Agent, the Issuing Bank or any Lender in connection with the
enforcement or protection of its rights in connection with this Agreement
(including its rights under this Section), the other Loan Documents or the Loans
made or Letters of Credit issued hereunder, including all such out-of-pocket
expenses incurred during any workout, restructuring or negotiations in respect
of such Loans or Letters of Credit, and, in connection with any such enforcement
or protection, the fees, charges and disbursements of any other counsel for the
Administrative Agent, the Collateral Agent, the Lead Arranger, the Issuing Bank
or any Lender; provided, however, that the Loan Parties shall not be obligated
to pay for expenses incurred by a Lender in connection with the assignment of
Loans to an assignee Lender (except pursuant to Section 2.21) or the sale of
Loans to a participant pursuant to Section 10.04.

                                     -127-

<PAGE>

                  (b)      Each of the Loan Parties, jointly and severally,
agrees to indemnify the Administrative Agent, the Collateral Agent, the
Syndication Agents, the Documentation Agent, the Lead Arranger, the Issuing
Bank, each Lender, each Affiliate of any of the foregoing Persons and each of
their respective Related Parties (each such Person being called an "Indemnitee")
against, and to hold each Indemnitee harmless from, any and all losses, claims,
damages, liabilities and related reasonable expenses, including reasonable
counsel fees, charges and disbursements, incurred by or asserted against any
Indemnitee arising out of, in any way connected with or as a result of (i) the
execution or delivery of this Agreement or any other Loan Document or any
agreement or instrument contemplated thereby, the performance by the parties
hereto or thereto of their respective obligations thereunder or the consummation
of the Transactions and the other transactions contemplated thereby, (ii) the
use of the proceeds of the Loans or Letters of Credit (including any refusal by
the Issuing Bank to honor a demand for payment under a Letter of Credit if the
documents presented in connection with such demand do not strictly comply with
the terms of such Letter of Credit), (iii) any claim, litigation, investigation
or proceeding relating to any of the foregoing, whether or not any Indemnitee is
a party thereto, or (iv) any actual or alleged presence or Release of Hazardous
Materials on any property owned or operated by the Borrower or any of the
Subsidiaries, or any Environmental Liability or Environmental Claim related in
any way to the Borrower or the Subsidiaries; provided that such indemnity shall
not, as to any Indemnitee, be available to the extent that such losses, claims,
damages, liabilities or related reasonable expenses are finally judicially
determined to have arisen by reason of the Indemnitee's gross negligence or
willful misconduct.

                  (c)      To the extent that the Loan Parties fail to promptly
pay any amount to be paid by them to any Agent, the Lead Arranger, the Issuing
Bank, the Foreign Currency Lender or the Swingline Lender under paragraph (a) or
(b) of this Section, each Lender severally agrees to pay to such Agent, the
Issuing Bank, Foreign Currency Lender or the Swingline Lender, as the case may
be, such Lender's pro rata share (determined as of the time that the applicable
unreimbursed expense or indemnity payment is sought) of such unpaid amount
(other than syndication expenses); provided that the unreimbursed expense or
indemnified loss, claim, damage, liability or related expense, as the case may
be, was incurred by or asserted against the applicable Agent, the Lead Arranger,
the Issuing Bank, Foreign Currency Lender or the Swingline Lender in its
capacity as such. For purposes hereof, a Lender's "pro rata share" shall be
determined based upon its share of the sum of the total Revolving Credit
Exposures, outstanding Term B Loans and unused Commitments at the time.

                  (d)      To the extent permitted by applicable law, the Loan
Parties shall not assert, and hereby waive, any claim against any Indemnitee, on
any theory of liability, for special, indirect, consequential or punitive
damages (as opposed to direct or actual damages) arising out of, in connection
with, or as a result of, this Agreement or any agreement or instrument
contemplated hereby, the Transactions, any Loan or Letter of Credit or the use
of the proceeds thereof.

                  (e)      The provisions of this Section 10.05 shall remain
operative and in full force and effect regardless of the expiration of the term
of this Agreement, the consummation of the transactions contemplated hereby, the
repayment of any of the Loans, the expiration of the Commitments, the invalidity
or unenforceability of any term or provision of this Agreement or

                                     -128-

<PAGE>

any other Loan Document, or any investigation made by or on behalf of the
Administrative Agent or any Lender. All amounts due under this Section 10.05
shall be payable on written demand therefor.

                  SECTION 10.06. Right of Setoff. If an Event of Default or
Event of Termination shall have occurred and be continuing, each Lender is
hereby authorized at any time and from time to time, to the fullest extent
permitted by law, to set off and apply any and all deposits (general or special,
time or demand, provisional or final) at any time held and other Indebtedness at
any time owing by such Lender to or for the credit or the account of the
Borrower against any of and all the obligations of the Borrower now or hereafter
existing under this Agreement and other Loan Documents held by such Lender,
irrespective of whether or not such Lender shall have made any demand under this
Agreement or such other Loan Document and although such obligations may be
unmatured. In connection with exercising its rights pursuant to the previous
sentence, a Lender may at any time use any of the Borrower's credit balances
with the Lender to purchase at the Lender's applicable spot rate of exchange any
other currency or currencies which the Lender considers necessary to reduce or
discharge any amount due by the Borrower to the Lender, and may apply that
currency or those currencies in or towards payment of those amounts. The rights
of each Lender under this Section are in addition to other rights and remedies
(including other rights of setoff) which such Lender may have. Each Lender
agrees promptly to notify the Borrower and the Administrative Agent after making
any such setoff.

                  SECTION 10.07. Applicable Law. THIS AGREEMENT AND THE OTHER
LOAN DOCUMENTS (OTHER THAN AS EXPRESSLY SET FORTH IN OTHER LOAN DOCUMENTS) SHALL
BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF NEW
YORK.

                  SECTION 10.08. Waivers; Amendment. (a) No failure or delay of
either Agent, the Issuing Bank or any Lender in exercising any power or right
hereunder or under any Loan Document shall operate as a waiver thereof, nor
shall any single or partial exercise of any such right or power, or any
abandonment or discontinuance of steps to enforce such a right or power,
preclude any other or further exercise thereof or the exercise of any other
right or power. The rights and remedies of the Agents, the Issuing Bank and the
Lenders hereunder and under the other Loan Documents are cumulative and are not
exclusive of any rights or remedies which they would otherwise have. No waiver
of any provision of this Agreement or any other Loan Document or consent to any
departure by the Borrower therefrom shall in any event be effective unless the
same shall be permitted by paragraph (b) below, and then such waiver or consent
shall be effective only in the specific instance and for the purpose for which
given. Without limiting the generality of the foregoing, the making of a Loan or
issuance of a Letter of Credit shall not be construed as a waiver of any Default
or Event of Default regardless of whether an Agent, any Lender or the Issuing
Bank may have had notice or knowledge of such Default or Event of Default at the
time. No notice or demand on the Borrower in any case shall entitle the Borrower
to any other or further notice or demand in similar or other circumstances.

                  (b)      Neither this Agreement, any other Loan Document nor
any provision hereof or thereof may be waived, amended or modified except, in
the case of this Agreement,

                                     -129-

<PAGE>

pursuant to an agreement or agreements in writing entered into by the Borrower
and the Requisite Lenders or, in the case of any other Loan Document, pursuant
to an agreement or agreements in writing entered into by the Agent and the Loan
Party or Loan Parties or other Persons that are parties thereto, in each case
with the consent of the Requisite Lenders; provided, however, that no such
agreement shall (i) decrease the principal amount of any Loan or LC
Disbursement, or extend the final scheduled maturity date or any Installment
Payment Date of the Loans or date for the payment of any interest on any Loan or
the required date of reimbursement of any LC Disbursement, or waive or excuse
any such payment or any part thereof, or decrease the rate of interest on any
Loan or LC Disbursement, or postpone the scheduled date of termination of any
Commitment, without the prior written consent of each Lender affected thereby,
(ii) change or extend the Commitment, Foreign Currency Sublimit or Maximum
Foreign Currency Sublimit or decrease the Commitment Fee or LC Fee of any Lender
without the prior written consent of such Lender, (iii) amend or modify the
provisions of Section 2.14, the provisions of this Section, the definition of
"Requisite Lenders," or any other provision of any Loan Document specifying the
number or percentage of Lenders (or Lenders of any Class) required to waive,
amend or modify any rights thereunder or make any determination or grant any
consent thereunder without the prior written consent of each Lender (or each
Lender of such Class, as the case may be), (iv) release any Loan Party from its
Guarantee under Article IX or a Guarantee Agreement (except as expressly
provided herein or in such Guarantee Agreement), or limit its liability in
respect of such Guarantee, without the written consent of each Lender, (v)
release all or substantially all of the Collateral from the Liens of the
Security Documents (except as expressly provided in this Agreement or the
Security Documents) or subordinate the Liens under any Security Document,
without the written consent of each Lender, (vi) amend Section 3.01 of the
Collateral Sharing Agreement without the written consent of each Lender or (vii)
change any provisions of any Loan Document in a manner that by its terms
adversely affects the rights in respect of payments due to Lenders holding Loans
of any Class differently than those holding Loans of any other Class, without
the written consent of Lenders holding a majority interest of the outstanding
Loans and unused Commitments of each affected Class; provided, further, that no
such agreement shall amend, modify or otherwise affect the rights or duties of
either Agent, the Lead Arranger, the Issuing Bank, Foreign Currency Lender or
the Swingline Lender hereunder or under any other Loan Document without the
prior written consent of such Agent, the Lead Arranger, the Issuing Bank,
Foreign Currency Lender or the Swingline Lender, as the case may be; provided,
further, that (x) with respect to (i) any change to Section 2.06(c), (ii) any
change to Section 2.06(g) or (iii) any amendment that changes the application of
any optional or mandatory prepayments of the Loans to the remaining amortization
payments under the Term B Loans, the consent of Term B Lenders representing more
than 50% of the outstanding Term B Loans shall be required, (y) the consent of
the Requisite Revolving Lenders shall be required with respect to any express
amendment, modification, supplement or waiver of any condition precedent in
Section 4.02 to any Revolving Credit Borrowing and (z) the consent of the
Requisite Foreign Currency Lenders shall be required for any modification of
Section 2.04 and any change to the definition of "Foreign Currency Lenders" or
"Foreign Currency Ratable Portion" or any related definitions.

                  (c)      A Revolving Lender may allocate any proportion of its
Revolving Credit Commitment or Revolving Credit Exposure with respect to any
waiver, amendment, modifica-

                                     -130-

<PAGE>

tion, consent or any other action pursuant to this Section 10.08 or any other
Loan Document in order to vote separate portions thereof differently with
respect thereto.

                  SECTION 10.09. Interest Rate Limitation. Notwithstanding
anything herein to the contrary, if at any time the interest rate applicable to
any Loan, together with all fees, charges and other amounts which are treated as
interest on such Loan under applicable law (collectively the "Charges"), shall
exceed the maximum lawful rate (the "Maximum Rate") which may be contracted for,
charged, taken, received or reserved by the Lender holding such Loan or
participation in accordance with applicable law, the rate of interest payable in
respect of such Loan or participation hereunder, together with all Charges
payable in respect thereof, shall be limited to the Maximum Rate and, to the
extent lawful, the interest and Charges that would have been payable in respect
of such Loan or participation but were not payable as a result of the operation
of this Section shall be cumulated and the interest and Charges payable to such
Lender in respect of other Loans or participations or periods shall be increased
(but not above the Maximum Rate therefor) until such cumulated amount, together
with interest thereon at the Federal Funds Effective Rate to the date of
repayment, shall have been received by such Lender.

                  SECTION 10.10. Entire Agreement. This Agreement and the other
Loan Documents constitute the entire contract between the parties relative to
the subject matter hereof. Any previous agreement among the parties with respect
to the subject matter hereof is superseded by this Agreement and the other Loan
Documents; provided that any letter agreement relating to the subject matter
hereof between the Borrower and a Lender shall remain effective in accordance
with its terms. Nothing in this Agreement or in the other Loan Documents,
expressed or implied, is intended to confer upon any party other than the
parties hereto and thereto any rights, remedies, obligations or liabilities
under or by reason of this Agreement or the other Loan Documents.

                  SECTION 10.11. WAIVER OF JURY TRIAL. EACH PARTY HERETO HEREBY
WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE
TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION ARISING OUT OF, UNDER OR IN
CONNECTION WITH THIS AGREEMENT OR ANY OF THE OTHER LOAN DOCUMENTS. EACH PARTY
HERETO (A) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER
PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT,
IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER AND (B)
ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN INDUCED TO ENTER
INTO THIS AGREEMENT AND THE OTHER LOAN DOCUMENTS, AS APPLICABLE, BY, AMONG OTHER
THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 10.11.

                  SECTION 10.12. Severability. In the event any one or more of
the provisions contained in this Agreement or in any other Loan Document should
be held invalid, illegal or unenforceable in any respect, the validity, legality
and enforceability of the remaining provisions contained herein and therein
shall not in any way be affected or impaired thereby. The parties shall endeavor
in good-faith negotiations to replace the invalid, illegal or unenforceable
provi-

                                     -131-

<PAGE>

sions with valid provisions the economic effect of which comes as close as
possible to that of the invalid, illegal or unenforceable provisions.

                  SECTION 10.13. Counterparts. This Agreement may be executed in
counterparts (and by different parties hereto on different counterparts), each
of which shall constitute an original but all of which when taken together shall
constitute a single contract, and shall become effective as provided in Section
10.03. Delivery of an executed signature page to this Agreement by facsimile
transmission shall be as effective as delivery of a manually signed counterpart
of this Agreement.

                  SECTION 10.14. Headings. Article and Section headings and the
Table of Contents used herein are for convenience of reference only, are not
part of this Agreement and are not to affect the construction of, or to be taken
into consideration in interpreting, this Agreement.

                  SECTION 10.15. Jurisdiction; Consent to Service of Process.
(a) The Borrower hereby irrevocably and unconditionally submits, for itself and
its property, to the nonexclusive jurisdiction of any New York State court or
Federal court of the United States of America sitting in New York City, and any
appellate court from any thereof, in any action or proceeding arising out of or
relating to this Agreement or the other Loan Documents, or for recognition or
enforcement of any judgment, and each of the parties hereto hereby irrevocably
and unconditionally agrees that all claims in respect of any such action or
proceeding may be heard and determined in such New York State or, to the extent
permitted by law, in such Federal court. Each of the parties hereto agrees that
a final judgment in any such action or proceeding shall be conclusive and may be
enforced in other jurisdictions by suit on the judgment or in any other manner
provided by law. Nothing in this Agreement shall affect any right that the
Administrative Agent, the Collateral Agent, the Issuing Bank or any Lender may
otherwise have to bring any action or proceeding relating to this Agreement or
the other Loan Documents against the Borrower or its properties in the courts of
any jurisdiction.

                  (b)      The Borrower hereby irrevocably and unconditionally
waives, to the fullest extent it may legally and effectively do so, any
objection which it may now or hereafter have to the laying of venue of any suit,
action or proceeding arising out of or relating to this Agreement or the other
Loan Documents in any New York State or Federal court referred to in paragraph
(a) of this Section. Each of the parties hereto hereby irrevocably waives, to
the fullest extent permitted by law, the defense of an inconvenient forum to the
maintenance of such action or proceeding in any such court.

                  (c)      Each party to this Agreement irrevocably consents to
service of process in the manner provided for notices in Section 10.01. Nothing
in this Agreement or any other Loan Document will affect the right of any party
to this Agreement to serve process in any other manner permitted by law.

                  SECTION 10.16. Confidentiality. (a) The Loan Parties, the
Lenders, the Administrative Agent and the Syndication Agents hereby agree that
each of the Loan Parties, the Lenders, the Administrative Agent and the
Syndication Agents and each of their respective officers, directors, employees,
agents, accountants, attorneys and other advisors are, and have been

                                     -132-

<PAGE>

from the commencement of discussions with respect to the facilities established
by this Agreement (the "Facilities"), permitted to disclose to any and all
Persons, without limitation of any kind, the structure and "tax aspects" (as
such terms are used in Code Sections 6011, 6111 and 6112 and the regulations
promulgated thereunder) of the Facilities, and all materials of any kind
(including opinions or other tax analyses) that are or have been provided to the
Loan Parties, such Lender, the Administrative Agent or the Syndication Agents
related to such structure and tax aspects. In this regard, each of the Loan
Parties, the Lenders, the Administrative Agent and the Syndication Agents
acknowledges and agrees that its disclosure of the structure or tax aspects of
the Facilities is not limited in any way by an express or implied understanding
or agreement, oral or written (whether or not such understanding or agreement is
legally binding). Furthermore, each of the Loan Parties, the Lenders, the
Administrative Agent and the Syndication Agents acknowledges and agrees that it
does not know or have reason to know that its use or disclosure of information
relating to the structure or tax aspects of the Facilities is limited in any
other manner (such as where the Facilities are claimed to be proprietary or
exclusive) for the benefit of any other Person. To the extent that disclosure of
the structure or tax aspects of the Facilities by the Loan Parties, the
Administrative Agent, the Syndication Agents or the Lenders is limited by any
existing agreement between the Loan Parties, the Administrative Agent, the
Syndication Agents or the Lenders, such limitation is agreed to be void ab
initio and such agreement is hereby amended to permit disclosure of the
structure and tax aspects of the Facilities as provided in this paragraph (a).

                  (b)      Subject to paragraph (a) of this Section 10.16, none
of the Administrative Agent, the Syndication Agents or any Lender may disclose
to any Person any confidential, proprietary or non-public information of the
Loan Parties furnished to the Administrative Agent, the Syndication Agents or
the Lenders by the Loan Parties (such information being referred to collectively
herein as the "Loan Party Information"), except that each of the Administrative
Agent, the Syndication Agents and the Lenders may disclose Loan Party
Information (i) to its and its affiliates' employees, officers, directors,
agents, accountants, attorneys and other advisors (it being understood that the
Persons to whom such disclosure is made will be informed of the confidential
nature of such Loan Party Information and instructed to keep such Loan Party
Information confidential on substantially the same terms as provided herein),
(ii) to the extent requested by any regulatory authority, (iii) to the extent
required by applicable laws or regulations or by any subpoena or similar legal
process, (iv) to any other party to this Agreement, (v) in connection with the
exercise of any remedies hereunder or under any other Loan Document or any suit,
action or proceeding relating to this Agreement or any other Loan Document or
the enforcement of rights hereunder or thereunder, (vi) subject to an agreement
containing provisions substantially the same as those of this Section 10.16(b),
to any assignee of or Participant in, or any prospective assignee of or
Participant in, any of its rights or obligations under this Agreement, (vii) to
the extent such Loan Party Information (A) is or becomes generally available to
the public on a nonconfidential basis other than as a result of a breach of this
Section 10.16(b) by any party to this Agreement, or (B) is or becomes available
to the Administrative Agent, the Syndication Agents or such Lender on a
nonconfidential basis from a source other than the Loan Parties and (viii) with
the consent of the Loan Parties. Nothing in this provision shall imply that any
party has waived any privilege it may have with respect to advice it has
received.

                                     -133-

<PAGE>

                  SECTION 10.17. Citigroup Direct Website Communications. (a)
Each Loan Party hereby agrees that it will provide to the Administrative Agent
all information, documents and other materials that it is obligated to furnish
to the Administrative Agent pursuant to the Loan Documents, including, without
limitation, all notices, requests, financial statements, financial and other
reports, certificates and other information material, but excluding any such
communication that (i) relates to a request for a new, or a conversion of an
existing, Borrowing or other extension of credit (including any election of an
interest rate or interest period relating thereto), (ii) relates to the payment
of any principal or other amount due under this Agreement prior to the scheduled
date therefore, (iii) provides notice of any Default or Event of Default under
this Agreement or (iv) is required to be delivered to satisfy any condition
precedent to the effectiveness of this Agreement and/or any borrowing or other
extension of credit hereunder (all such non-excluded communications being
referred to herein collectively as "Communications"), by transmitting the
Communications in an electronic/soft medium in a format acceptable to the
Administrative Agent to oploanswebadmin@citigroup.com. In addition, each Loan
Party agrees to continue to provide the Communications to the Administrative
Agent in the manner specified in the Loan Documents but only to the extent
requested by the Administrative Agent.

                  (b)      Each Loan Party further agrees that the
Administrative Agent may make the Communications available to the Lenders by
posting the Communications on Intralinks, Fixed Income Direct or a substantially
similar electronic transmission systems (the "Platform"). Each Loan Party
acknowledges that the distribution of material through an electronic medium is
not necessarily secure and that there are confidentiality and other risks
associated with such distribution.

                  (c)      THE PLATFORM IS PROVIDED "AS IS" AND "AS AVAILABLE".
THE AGENT PARTIES (AS DEFINED BELOW) DO NOT WARRANT THE ACCURACY OR COMPLETENESS
OF THE COMMUNICATIONS, OR THE ADEQUACY OF THE PLATFORM AND EXPRESSLY DISCLAIM
LIABILITY FOR ERRORS OR OMISSIONS IN THE COMMUNICATIONS. NO WARRANTY OF ANY
KIND, EXPRESS, IMPLIED OR STATUTORY, INCLUDING, WITHOUT LIMITATION, ANY WARRANTY
OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT OF
THIRD-PARTY RIGHTS OR FREEDOM FROM VIRUSES OR OTHER CODE DEFECTS, IS MADE BY THE
AGENT PARTIES IN CONNECTION WITH THE COMMUNICATIONS OR THE PLATFORM. IN NO EVENT
SHALL THE ADMINISTRATIVE AGENT OR ANY OF ITS AFFILIATES OR ANY OF THEIR
RESPECTIVE OFFICERS, DIRECTORS, EMPLOYEES, AGENTS, ADVISORS OR REPRESENTATIVES
(COLLECTIVELY, "AGENT PARTIES") HAVE ANY LIABILITY TO THE LOAN PARTIES, ANY
LENDER OR ANY OTHER PERSON OR ENTITY FOR DAMAGES OF ANY KIND, INCLUDING, WITHOUT
LIMITATION, DIRECT OR INDIRECT, SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES,
LOSSES OR EXPENSES (WHETHER IN TORT, CONTRACT OR OTHERWISE) ARISING OUT OF THE
LOAN PARTIES' OR THE ADMINISTRATIVE AGENT'S TRANSMISSION OF COMMUNICATIONS
THROUGH THE INTERNET, EXCEPT TO THE EXTENT THE LIABILITY OF ANY AGENT PARTY IS
FOUND IN A FINAL, NON-APPEALABLE JUDGMENT BY A COURT OF COMPETENT JURISDICTION
TO

                                     -134-

<PAGE>

HAVE RESULTED PRIMARILY FROM SUCH AGENT PARTY'S GROSS NEGLIGENCE OR WILLFUL
MISCONDUCT.

                  The Administrative Agent agrees that the receipt of the
Communications by the Agent at its e-mail address set forth above shall
constitute effective delivery of the Communications to the Administrative Agent
for purposes of the Loan Documents. Each Lender agrees that notice to it (as
provided in the next sentence) specifying that the Communications have been
posted to the Platform shall constitute effective delivery of the Communications
to such Lender for purposes of the Loan Documents. Each Lender agrees (i) to
notify the Administrative Agent in writing (including by electronic
communication) from time to time of such Lender's e-mail address to which the
foregoing notice may be sent by electronic transmission and (ii) that the
foregoing notice may be sent to such e-mail address.

                  Nothing herein shall prejudice the right of the Administrative
Agent or any Lender to give any notice or other communication pursuant to any
Loan Document in any other manner specified in such Loan Document.

                  SECTION 10.18. Collateral Agent as Joint Creditor. Each of the
Loan Parties and each of the Lenders agree that the Collateral Agent shall be
the joint creditor (together with the relevant Lender) of each and every
obligation of the Loan Parties towards each of the Lenders under or in
connection with the Loan Documents, and that accordingly the Collateral Agent
will have its own independent right to demand performance by the Loan Parties of
those obligations. However, any discharge of any such obligation to the
Collateral Agent or the relevant Lender shall, to the same extent, discharge the
corresponding obligation owing to the other.

                  SECTION 10.19. Currency of Payment. (a) Each payment owing by
the Borrower hereunder shall be made in the relevant currency specified herein
or, if not specified herein, specified in any other Loan Document executed by
the Administrative Agent (the "Currency of Payment") at the place specified
herein (such requirement is of the essence of this Agreement). If, for the
purpose of obtaining judgment in any court, it is necessary to convert a sum due
hereunder in a Currency of Payment into another currency, the parties hereto
agree that the rate of exchange used shall be that at which in accordance with
normal banking procedures the Administrative Agent could purchase such Currency
of Payment with such other currency at the spot rate of exchange quoted by the
Administrative Agent at 11:00 a.m. (New York time) on the Business Day preceding
that on which final judgment is given, for delivery two Business Days
thereafter. The obligations in respect of any sum due hereunder to any Secured
Party shall, notwithstanding any adjudication expressed in a currency other than
the Currency of Payment, be discharged only to the extent that, on the Business
Day following receipt by such Secured Party of any sum adjudged to be so due in
such other currency, such Secured Party may, in accordance with normal banking
procedures, purchase the Currency of Payment with such other currency. The
Borrower agrees that (a) if the amount of the Currency of Payment so purchased
is less than the sum originally due to such Secured Party in the Currency of
Payment, as a separate obligation and notwithstanding the result of any such
adjudication, the Borrower shall immediately pay the shortfall (in the Currency
of Payment) to such Secured Party and (b) if the amount of the Currency of
Payment so purchased exceeds the sum originally due to such

                                     -135-

<PAGE>

Secured Party, such Secured Party shall promptly pay the excess over to the
Borrower in the currency and to the extent actually received.

                  (b)      The Obligations owing to any Secured Party hereunder
shall, notwithstanding any payment in a currency other than the Currency of
Payment and notwithstanding any deemed conversion or replacement hereunder, be
discharged only to the extent that, on the Business Day following receipt by
such Secured Party of any amount in such other currency, such Secured Party may,
in accordance with normal banking procedures, purchase the Currency of Payment
with such other currency. The Borrower agrees that (i) if the amount of the
Currency of Payment so purchased is less than the sum originally due to such
Secured Party in the Currency of Payment, as a separate obligation and
notwithstanding the result of any such adjudication, the Borrower shall
immediately pay the shortfall (in the Currency of Payment) to such Secured Party
and (ii) if the amount of the Currency of Payment so purchased exceeds the sum
originally due to such Secured Party, such Secured Party shall promptly pay the
excess over to the Borrower in the currency and to the extent actually received.

                  SECTION 10.20. Relationship of Banc One Mezzanine Corporation.

                  (a)      Each of the parties to this Agreement (a)
acknowledges that Banc One Mezzanine Corporation is a subsidiary of Bank One
Corporation, as is OEP, (b) consents to these multiple roles, and further
acknowledges that the fact that OEP and the Borrower are affiliates of Banc One
Mezzanine Corporation does not mean that any action taken or proposal made by
OEP or the Borrower (i) is acceptable to Banc One Mezzanine Corporation in its
capacity as Co-Syndication Agent or Lender hereunder, (ii) is consistent with
the terms of this Agreement or (iii) is or will be acceptable to any other
Lenders, and (c) Banc One Mezzanine Corporation shall not be deemed to have
knowledge of information known to the Borrower or OEP simply because they are
affiliates.

                            [Signature Pages Follow]

                                     -136-
<PAGE>

                  IN WITNESS WHEREOF, the parties hereto have caused this
Agreement to be duly executed by their respective authorized officers as of the
day and year first above written.

                                         QUINTILES TRANSNATIONAL CORP.,
                                         as Borrower

                                         By: -s- James L. Bierman
                                             -----------------------------------
                                             Name: JAMES L. BIERMAN
                                             Title:

<PAGE>

                                         PHARMA SERVICES HOLDING, INC.,
                                         as a Parent Guarantor

                                         By: -s- Dennis B. Gillings
                                             -----------------------------------
                                             Name: DENNIS B. GILLINGS
                                             Title:

                                         PHARMA SERVICES INTERMEDIATE
                                         HOLDING CORP., as a Parent Guarantor

                                         By: -s- Dennis B. Gillings
                                             -----------------------------------
                                             Name: DENNIS B. GILLINGS
                                             Title:

<PAGE>

                                         CITICORP NORTH AMERICA, INC.,
                                         as Administrative Agent

                                         By: -s- Andrew Robinson
                                             -----------------------------------
                                             Name: ANDREW ROBINSON
                                             Title: VICE PRESIDENT

<PAGE>

                                       CITIGROUP GLOBAL MARKETS INC.,
                                       as Sole Lead Arranger and Sole Bookrunner

                                       By: -s- Andrew Robinson
                                           -----------------------------------
                                           Name: ANDREW ROBINSON
                                           Title: VICE PRESIDENT

<PAGE>

                                         ABN AMRO BANK N. V.,
                                         as Co-Syndication Agent

                                         By: -s- Alex Blodi
                                             -----------------------------------
                                         Name: Alex Blodi
                                         Title: Director

                                         By: -s- Todd J. Miller
                                             -----------------------------------
                                         Name: Todd J. Miller
                                         Title: Assistant Vice President

<PAGE>

                                         BANC ONE MEZZANINE CORPORATION,
                                         as Co-Syndication Agent And Lender

                                         By: -s- Marsha A. Cruzan
                                             -----------------------------------
                                             Name: MARSHA A. CRUZAN
                                             Title: MANAGING DIRECTOR

                                      S-1

<PAGE>

                                         ABN AMRO Bank N.V., as Revolving Lender

                                         By: -s- Alexander M. Blodi
                                             -----------------------------------
                                         Name: Alexander M. Blodi
                                         Title: Director

                                         By: -s- Todd J. Miller
                                             -----------------------------------
                                         Name: Todd. J. Miller
                                         Title: Assistant Vice President

<PAGE>

                                         CITICORP NORTH AMERICA, INC.,
                                         as Term B Lender

                                         By: -s- Andrew Robinson
                                             -----------------------------------
                                             Name: ANDREW ROBINSON
                                             Title: VICE PRESIDENT

                                         CITICORP NORTH AMERICA, INC.,
                                         as Revolving Lender

                                         By: -s- Andrew Robinson
                                             -----------------------------------
                                             Name: ANDREW ROBINSON
                                             Title: VICE PRESIDENT

<PAGE>

                                         Residential Funding Corporation, as
                                         Lender and Documentation Agent

                                         By: -s- Kevin Howell
                                             -----------------------------------
                                             Name: Kevin Howell
                                             Title: Senior Vice President

                                       S-2

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