Document:

EXHIBIT
      10.1

    

    ADDENDUM
      TO PROMISSORY NOTE

    

    THIS
      ADDENDUM TO PROMISSORY NOTE (this " Addendum") is dated November 18, 2005,
      between MICROHELIX, INC., an Oregon corporation (the "Borrower"), and MARTI
      D.
      LUNDY (the "Lender").

     

    A. Borrower
      made a Promissory Note dated April 8, 2005 (the "Note") in favor of the Lender
      in the principal amount of $1,250,000.00; and

     

    B. The
      parties desire to amend the Note pursuant to the terms of this
      Addendum.

     

    For
      good
      and valuable consideration, the receipt and sufficiency of which are hereby
      acknowledged, the parties agree as follows:

     

    1.  Continuing
      Effectiveness.
      Except
      as modified herein, all of the terms, conditions, covenants, and restrictions
      set forth in the Note shall remain in full force and effect among the
      parties.

     

    2.  Payment.
      Section
      1 of the Note shall be amended in its entirety to read as follows: "Subject
      to
      the terms and conditions of this Note, Borrower promises to pay to the order
      of
      Lender the principal amount of One Million Two Hundred Fifty Thousand Dollars
      ($1,250,000), together with interest on the unpaid principal mount from the
      date
      of this Note. The first six payments are due on May 8, 2005, June 8, 2005,
      July
      8, 2005, August 8, 2005, September 8, 2005, and October 8, 2005, and these
      payments shall be interest-only payments in the amount of $10,416.67 each.
      A
      payment in the amount of $23,482.16 each shall be due on November 8, 2005 and
      December 8, 2005 that includes an interest payment of $10,417.67 and a principal
      payment of $13,064.49. A payment in the amount of $43,482.16 shall be due on
      January 8, 2006 and subsequent payments of $43,482.16 each are due on the eight
      day of each following month until April 8, 2008, at which time the unpaid
      principal amount, together with accrued interest is due in its entirety."
      Section 1 of the Note as amended herein shall remain in full force and effect
      among the parties.

    
      	 	 	 
	 	BORROWER:
	 	 
	 	MICROHELIX, INC., an Oregon
              corporation 
	 
 	 
 	 
 
	 	By:  	/s/ Tyram
              H. Pettit
	 	
              
Tyram
              H. Pettit
	 	Title: President
              & CEO

    

    
      
        	 	 	 
	 	LENDER:
	 
 	 
 	 
 
	 	  	/s/ Marti
                D. Lundy
	 	
                
Marti
                D. LundyExclusive Agency Agreement

      This  agreement  is made  and  entered  into by and  between  the  parties
concerned  in  Beijing,  China on the basis of  equality  and mutual  benefit to
develop business on terms and conditions mutually agreed upon as follow:

      1.

      The Parties Concerned

      Party A: Xinhua Surgical Instruments Co., Ltd.

      Add: No.2, Honggou, Zhangdian, Zibo, Shandong

      Tel: +86(533)2182006

      Fax: +86(533)2182027

      Party B: Bio-Bridge Science, Inc.

      Add: 1211 W. 22nd Street, Oak Brook, IL 60523, USA

      Tel: +1(630)9280869

      Fax: +1(630)2036088

      2.

      Appointment

      Party A hereby  appoints Party B as its Exclusive  Agent to solicit orders
for the  commodity  stipulated  in  Article 3 from  customers  in the  territory
stipulated in Article 4, and Party B accepts and assumes such appointment.

      3.

      Commodity

      "XINHUA" Brand Surgical  Instruments and other related products (listed in
2005 product catalog)

      4.

      Territory

      In the United States Only

      5.

      Minimum turnover

      During  the  first 12 months of the  effective  period of this  agreement,
Party B investigate and develop the market without the minimum turnover. Party B
shall  undertake to solicit orders for the above commodity from customers in the
above  territory  for not less than USD 50,000 in the  second  year and not less
than USD 60,000 in the third year.  Annually,  from the fourth year, the minimum
turnover  shall be  progressively  increased  with 10  percent  of the  previous
minimum turnover.

      6.

      Confirmation of Orders

                                       2
<PAGE>

      The  quantities,  prices and shipments of the  commodities  stated in this
Agreement shall be confirmed in each  transaction,  the particulars of which are
to be specified in the Sales Confirmation signed by the two parties hereto.

      7. Terms of payment

      After  confirmation of the order,  Party B shall pay to Party A 50% of the
total value in cash within the time  stipulated  in the  relevant  S/C.  Party B
shall pay to Party A the rest of the payment within 30 days after the receipt of
the goods.

      8. Quality Guarantee

      Party A shall  guarantee that the commodity must be in conformity with the
quantity,  specifications  and quantity specified in this Contract and Letter of
Quality  Guarantee.  Party A shall  be  responsible  for the  damage  due to the
defects in designing and manufacturing of Party A.

      9.

      Inspection

      Party  A  shall,  before  delivery,   make  a  precise  and  comprehensive
inspection of the goods with regard to its quality, specifications,  performance
and quantity,  and issue inspection  certificates  certifying the technical data
and  conclusion  of the  inspection.  After  arrival of the goods at the port of
destination, Party B shall further inspect as to the specifications and quantity
of the goods.  If damages of the goods are found, or the  specifications  and/or
quantity are not in conformity with the stipulations in the Sales  Confirmation,
except  when the  responsibilities  lies  with  Insurance  Company  or  Shipping
Company, Party B shall, within 30 days after arrival of the goods at the port of
destination, claim against Party A, or reject the goods.

                                       3
<PAGE>

      10.

      Claim

      Party B shall make a claim against Party A (including  replacement  of the
goods) by the further  inspection and all the expenses incurred  therefrom shall
be borne by Party A. The  claims  mentioned  above  shall be  regarded  as being
accepted if Party A fail to reply  within 10 days after  Party A received  Party
B's claim.

      11. Exclusive Right

      In  consideration  of the exclusive  rights granted herein,  Party A shall
not, directly or indirectly,  sell or export the commodity stipulated in Article
3 to customers in the United States through  channels  (third country  included)
other than Party B; Party B shall not sell,  distribute  or promote the sales of
any products  competitive  with or similar to the above  commodity in the United
States and shall not solicit or accept  orders for the  purpose of selling  them
outside  the United  States.  Party A shall  refer to Party B any  enquiries  or
orders for the commodity in question received by Party A from other firms in the
United States during the validity of this agreement.

      12.

      Market Report

      In  order  to  keep  Party  A  well  informed  of  the  prevailing  market
conditions,  Party B should undertake to supply Party A, at least once a quarter
or at any time when  necessary,  with market reports  concerning  changes of the
local  regulations  in  connection  with the import  and sales of the  commodity
covered by this  agreement,  local market tendency and the Party B's comments on
quality,  packing,  price,  etc.  of the goods  supplied  by Party A under  this
agreement.  Party B shall also supply party A with  quotations  and  advertising
materials on similar products of other suppliers.

                                       4
<PAGE>

      13.

      Advertising and Expenses

      Party  B  shall  bear  all  expenses  for  advertising  and  publicity  in
connection  with the  commodity  in  question  in the United  States  within the
validity  of this  agreement.  Party  B  shall  submit  to  Party A all  related
materials intended for advertising for prior approval.

      14.

      Industrial Property Rights

      Party B may use  the  trade-marks  owned  by  Party A for the  sale of the
Surgical  Instruments covered herein within the validity of this agreement,  and
shall  acknowledge  that all  patents,  trademarks,  copy  rights  or any  other
industrial  property  rights used or embodied in the Surgical  Instrments  shall
remain to be the sole  properties of Party A. Should any  infringement be found,
Party B shall  promptly  notify and assist  Party A to take steps to protect the
latter's rights.

      15. Validity of Agreement

      This  agreement,  when duly signed by the both  parties  concerned,  shall
become effective from November 16, 2005, and it shall be extended unless Party B
fail to fulfill the minimum turnover stipulated in Article 5.

      16.

      Force Majeure

      Either party shall not be held responsible for failure or delay to perform
all or any part of this agreement due to flood, fire,  earthquake,  draught, war
or any  other  events  which  could not be  predicted,  controlled,  avoided  or
overcome by the  relative  party.  However,  the party  affected by the event of
Force Majeure shall inform the other party of its  occurrence in writing as soon
as  possible  and  thereafter  send a  certificate  of the  event  issued by the
relevant authorities to the other party within 15 days after its occurrence.

                                       5
<PAGE>

      17. Arbitration

      All  disputes  arising from the  performance  of this  agreement  shall be
settled through friendly  negotiation.  Should no settlement be reached throught
negotiation,  the case  shall then be  submitted  for  arbitration  to the China
International  Economic and Trade Arbitration Commission (Beijing) and the rules
of this Commission shall be applied. The award of the arbitration shall be final
and binding upon both parties.

      18.

      Other Terms & Conditions

      (1)

      Terms of Price

      Description, Article No., Specification, Unit Price (CIF) shall be subject
to those listed in 2005 product catalog  ,tariff and enclosure.  The Price (CIF)
shall be properly adjusted on conditions mutually agreed upon at a proper time.

      (2)

      This Agreement  shall be subject to the terms and conditions in the formal
Sales Contract signed by both parties hereto.

      (3)

      Additional Clause

      Conflicts between  agreement clause here-above and the additional  clause,
if any, it is subject to the additional clause.

                                       6
<PAGE>

      (4)

      This Agreement is in two originals each Party holds one.

Party A: Xinhua Surgical Instruments Co., Ltd.  Party B: Bio-Bridge Science, Inc

         /s/ ineligible                                 /s/ Liang Qiao

              (Signature)                                (Signature)

                                       7

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