Document:

EX-10.4

 EXHIBIT 10.4 

FIRST AMENDMENT 
 TO 

REGISTRATION AGREEMENT 
 This
First Amendment to Registration Agreement (this “Amendment”), is made and entered into effective as of October 30, 2014 (the “Effective Date”), and amends that certain Registration Agreement, dated as of
January 4, 2013, by and among ECPM Holdings, LLC, a Delaware limited liability company (the “Company”), and the other parties thereto (the “Registration Agreement”). All capitalized terms used in this Amendment
and not defined herein shall have the meanings set forth in the Registration Agreement. 
 RECITALS 

A. The Company desires to amend the Registration Agreement in order to amend the definition of “Investor Registrable Securities”, as
more specifically described herein. 
 B. The Board of Managers of the Company has approved this Amendment by unanimous written consent
effective as of October 29, 2014. 
 C. The undersigned holders of units of membership interests of the Company collectively constitute
holders of a majority of each of the Investor Registrable Securities and the Other Registrable Securities. 
 D. For purposes of approving
the Amendment in accordance with Section 9(d) of the Registration Agreement, the undersigned hereby consent to the adoption of this Amendment and the terms and conditions contained herein. 

AMENDMENTS 
 NOW,
THEREFORE, in consideration of the mutual agreements, terms, conditions, and covenants set forth in this Amendment, the parties agree as follows: 

1. Effective Date. This Amendment shall be effective as of the Effective Date. 

2. Amendments. 
 a. The
first “WHEREAS” clause following the introductory paragraph of the Registration Agreement is hereby amended by deleting the phrase “of even date herewith” (which is referenced two (2) times) and replacing it in both
instances with the phrase “dated as of October 6, 2012”. 
 b. The definition of “Other Registrable Securities” in
Section 8(d) of the Registration Agreement is hereby amended by deleting the first sentence in its entirety and replacing it with the following: 

““Other Registrable Securities” means (i) any Common Stock issued or issuable upon the conversion of any Class B
Unit or Class C Unit issued pursuant to the Contribution Agreement, (ii) any Common Stock issued or issuable upon the conversion of any Class A Units issued to any Other Holder pursuant to the Purchase Agreement, (iii) any Common
Stock issued or issuable with respect to the securities referred to in clause (i) or 

 
clause (ii) above by way of a dividend or split of equity securities or in connection with a combination of equity securities, recapitalization, merger, consolidation or other
reorganization, and (iv) any other shares of Common Stock held by Persons holding securities described in clauses (i), (ii) and (iii) above (in each case, other than Investor Registrable Securities).” 

3. Registration Agreement to Remain in Full Force and Effect. Except as specifically provided herein, the Registration Agreement, as
amended by this Amendment, shall remain in full force and effect, and the provisions thereof are hereby ratified and confirmed. 
 4.
Sufficiency of Consent. The undersigned hereby acknowledge and agree that the consent of the undersigned provided herein, together with the approval by the Board of Managers of the Company (which has been separately obtained), constitutes all
the consents and approvals required to adopt this Amendment. 
 5. Further Actions. The undersigned hereby agree to take such actions
and to execute such documents and other instruments as may be necessary or desirable to give effect to the purposes of this Amendment. Furthermore, the undersigned hereby consent to the taking of any actions and the execution of any documents or
other instruments by any officer of the Company deemed by such officer necessary or desirable to give effect to the purposes of this Amendment. 

6. Governing Law. This Amendment shall be governed by the laws of the State of Delaware, without giving effect to principles of
conflict of laws of that State. 
 7. Counterparts. This Amendment may be executed in one or more counterparts, each of which shall
be deemed an original, and all of which shall constitute one instrument. 
 { Signature page to follow } 

  
 2 

 IN WITNESS WHEREOF, the undersigned has executed this Amendment as of the date first set forth
above. 
  

			
	 THE COMPANY:

	
	 ECPM HOLDINGS, LLC

		
	 By:
		 /s/ Mark Gilreath

			 Mark Gilreath

			 President

 Signature Page to First Amendment to Registration Rights Agreement 

 
			
	REQUISITE HOLDERS INVESTOR REGISTRABLE SECURITIES:
	
	SC US GF V HOLDINGS, LTD.,
	a Cayman Islands exempted company
		
	By:		SEQUOIA CAPITAL U.S. GROWTH FUND V, L.P.,
			a Cayman Islands exempted limited partnership, its member
		
	By:		SCGF V MANAGEMENT, L.P.,
			a Cayman Islands exempted limited partnership, its General Partner
		
	By:		SC US (TTGP), LTD.,
			a Cayman Islands exempted company, its General Partner
		
	By:		 /s/ Scott Carter

	Name:		 Scott Carter

	Title:		Director

 Signature Page to First Amendment to Registration Rights Agreement 

 
			
	REQUISITE HOLDERS OTHER REGISTRABLE SECURITIES:
	
	RIVER CITIES CAPITAL FUND IV L.P.
		
	By:		River Cities Management IV LLC
	Its:		General Partner
		
	By:		 /s/ Edwin T. Robinson

	Name:		 Edwin T. Robinson

	Title:		 Manager

	
	RIVER CITIES CAPITAL FUND IV (N.Q.P.) L.P.
		
	By:		River Cities Management IV LLC
	Its:		General Partner
		
	By:		 /s/ Edwin T. Robinson

	Name:		 Edwin T. Robinson

	Title:		 Manager

	
	COUNCIL CAPITAL II, L.P.
		
	By:		Council Capital Partners II, LLC
	Its:		General Partner
		
	By:		 /s/ Katie H. Gambill

	Name:		 Katie H. Gambill

	Title:		 Managing Member

	
	ENVEST III, LLC
		
	By:		Envest Management III, LLC
	Its:		Managing Member
		
	By:		 /s/ David Kaufman

	Name:		 David Kaufman

	Title:		 Manager

 Signature Page to First Amendment to Registration Rights Agreement 

 
			
	U.M. ACCELMED L.P.
		
	By:		U.M. Accelmed Management (2009) Ltd.
	Its:		General Partner
		
	By:		 /s/ Uri Geiger

	Name:		 Uri Geiger

	Title:		 Managing Partner

 Signature Page to First Amendment to Registration Rights AgreementEX-10.5

 EXHIBIT 10.5 

SECOND AMENDMENT 
 TO 

REGISTRATION AGREEMENT 
 This
Second Amendment to Registration Agreement (this “Amendment”), is made and entered into effective as of March 4, 2015 (the “Effective Date”), and amends that certain Registration Agreement, dated as of
January 4, 2013, by and among ECPM Holdings, LLC, a Delaware limited liability company (the “Company”), and the other parties thereto, as amended by that certain First Amendment to Registration Agreement, effective as of
October 30, 2014 (the “Registration Agreement”). All capitalized terms used in this Amendment and not defined herein shall have the meanings set forth in the Registration Agreement. 

RECITALS 
 A. The Company
desires to amend the Registration Agreement in order to amend the definition of “Investor Registrable Securities”, as more specifically described herein and to add certain Other Holders. 

B. The Board of Managers of the Company has approved this Amendment by unanimous written consent effective as of February 28, 2015. 

C. The undersigned holders of units of membership interests of the Company collectively constitute holders of a majority of each of the
Investor Registrable Securities and the Other Registrable Securities. 
 D. For purposes of approving the Amendment in accordance with
Section 9(d) of the Registration Agreement, the undersigned hereby consent to the adoption of this Amendment and the terms and conditions contained herein. 

AMENDMENTS 
 NOW,
THEREFORE, in consideration of the mutual agreements, terms, conditions, and covenants set forth in this Amendment, the parties agree as follows: 

1. Effective Date. This Amendment shall be effective as of the Effective Date. 

2. Amendments. 
 a.
Section 1(b) of the Registration Agreement is hereby amended by deleting the first sentence of Section 1(b) and replacing it with the following: 

“Either (x) the Investors holding a majority of the Investor Registrable Securities held by all Investors or (y) the holders of
a majority of the Investor Registrable Securities shall be entitled to request two (2) Long-Form Registrations in which the Company shall pay all Registration Expenses (“Company-paid Long-Form Registrations”); provided
that the aggregate offering value of the Investor Registrable Securities requested to be registered in any Long-Form Registration is at least $10 million.” 

b. The second sentence of Section 1(b) of the Registration Agreement is hereby amended by (a) inserting the phrase “or holders
effecting the demand” immediately following the first reference to “Investors” and (b) inserting the phrase “or holders” immediately following the second reference to to “Investors”. 

 c. The definition of “Investor Registrable Securities” in Section 8(c) of the
Registration Agreement is hereby amended by deleting the first sentence in its entirety and replacing it with the following: 

““Investor Registrable Securities” means (i) any Common Stock issued or issuable upon the conversion of any
Class A Unit (including any Class A-1 Unit) issued pursuant to any of the Class A Unit Purchase Agreements, (ii) any Common Stock issued or issuable with respect to the securities referred to in clause (i) above by way of a
dividend or split of equity securities or in connection with a combination of equity securities, recapitalization, merger, consolidation or other reorganization, and (iii) any other shares of Common Stock held by Persons holding securities
described in clauses (i) and (ii) above (it being acknowledged that following an IPO, any Other Registrable Securities held by Other Holders that also hold securities described in clauses (i) or (ii) above shall constitute
Investor Registrable Securities).” 
 d. Section 8 of the Registration Agreement is hereby amended by adding a new definition for
“Class A Unit Purchase Agreements” immediately following the definition of “Common Stock”, which reads as follows: 

““Class A Unit Purchase Agreements” means any of (i) the Purchase Agreement, (ii) that certain Unit Purchase
Agreement, dated as of October 30, 2014, among the Company and the Purchasers named therein and/or (iii) that certain Unit Purchase Agreement, dated as of March 4, 2015, among the Company and the Purchasers named therein.” 

e. The Schedule of Other Holders attached to the Registration Agreement is hereby amended by adding the Other Holders listed on
Schedule 1 attached hereto, and such additional Other Holders listed on Schedule 1 shall be added as parties to the Registration Agreement as Other Holders upon their execution and delivery to the Company of a joinder, in a form
substantially similar to the joinder attached as Exhibit A to the Registration Agreement. 
 f. The Schedule of Investors
attached to the Registration Agreement is hereby amended by adding the Investor listed on Schedule 2 attached hereto, and such additional Investor listed on Schedule 2 shall be added as parties to the Registration Agreement as an
Investor upon its execution and delivery to the Company of a joinder, in a form substantially similar to the joinder attached as Exhibit A to the Registration Agreement. 

3. Registration Agreement to Remain in Full Force and Effect. Except as specifically provided herein, the Registration Agreement, as
amended by this Amendment, shall remain in full force and effect, and the provisions thereof are hereby ratified and confirmed. 
 4.
Sufficiency of Consent. The undersigned hereby acknowledge and agree that the consent of the undersigned provided herein, together with the approval by the Board of Managers of the Company (which has been separately obtained), constitutes all
the consents and approvals required to adopt this Amendment. 

  
 2 

 5. Further Actions. The undersigned hereby agree to take such actions and to execute such
documents and other instruments as may be necessary or desirable to give effect to the purposes of this Amendment. Furthermore, the undersigned hereby consent to the taking of any actions and the execution of any documents or other instruments by
any officer of the Company deemed by such officer necessary or desirable to give effect to the purposes of this Amendment. 
 6.
Governing Law. This Amendment shall be governed by the laws of the State of Delaware, without giving effect to principles of conflict of laws of that State. 

7. Counterparts. This Amendment may be executed in one or more counterparts, each of which shall be deemed an original, and all of
which shall constitute one instrument. 
 { Signature page to follow } 

  
 3 

 IN WITNESS WHEREOF, the undersigned has executed this Amendment as of the date first set forth
above. 
  

			
	THE COMPANY:
	
	ECPM HOLDINGS, LLC
		
	By:		 /s/ Mark G. Gilreath

			Mark Gilreath
			President

 Signature Page to Second Amendment to Registration Rights Agreement 

 
			
	REQUISITE HOLDERS INVESTOR REGISTRABLE SECURITIES:
	
	 SC US GF V HOLDINGS, LTD.
 a Cayman
Islands exempted company

		
	By:		SEQUOIA CAPITAL U.S. GROWTH FUND V, L.P.
			SEQUOIA CAPITAL USGF PRINCIPALS FUND V, L.P.
			both Cayman Islands exempted limited partnerships, its Members
		
	By:		SCGF V MANAGEMENT, L.P.,
			a Cayman Islands exempted limited partnership, its General Partner
		
	By:		SC US (TTGP), LTD.,
			a Cayman Islands exempted company, its General Partner
		
	By:		
	
	 /s/ Scott Carter

	Name:		Scott Carter
	Title:		Director

 Signature Page to Second Amendment to Registration Rights Agreement 

 
			
	REQUISITE HOLDERS OTHER REGISTRABLE SECURITIES:
	
	RIVER CITIES CAPITAL FUND IV L.P.
		
	By:		River Cities Management IV LLC
	Its:		General Partner
		
	By:		 /s/ Edward C. McCarthy

	Name:		 Edward C. McCarthy

	Title:		 Manager

	
	RIVER CITIES CAPITAL FUND IV (N.Q.P.) L.P.
		
	By:		River Cities Management IV LLC
	Its:		General Partner
		
	By:		 /s/ Edward C. McCarthy

	Name:		 Edward C. McCarthy

	Title:		 Manager

	
	COUNCIL CAPITAL II, L.P.
		
	By:		Council Capital Partners II, LLC
	Its:		General Partner
		
	By:		 /s/ Dennis C. Bottorff

	Name:		 Dennis C. Bottorff

	Title:		 Managing General Partner

	
	ENVEST III, LLC
		
	By:		Envest Management III, LLC
	Its:		Managing Member
		
	By:		 /s/ David Kaufman

	Name:		 David Kaufman

	Title:		 Manager

 Signature Page to Second Amendment to Registration Rights Agreement 

 
			
	U.M. ACCELMED L.P.
	
	By: U.M. Accelmed Management (2009) Ltd.
	Its: General Partner
		
	By:		 /s/ Uri Geiger

	Name:		 Uri Geiger

	Title:		 Managing Partner

	
	EVERGREEN V, L.P.
	By: Evergreen V GP, L.P, its general partner
	By: Evergreen 5 G.P. Ltd., its general partner
		
	By:		 /s/ Ronit Bendori

	Name:		 Ronit Bendori

	Title:		 Partner

	
	EVERGREEN V-A, L.P.
	By: Evergreen V GP, L.P, its general partner
	By: Evergreen 5 G.P. Ltd., its general partner
		
	By:		 /s/ Ronit Bendori

	Name:		 Ronit Bendori

	Title:		 Partner

 Signature Page to Second Amendment to Registration Rights Agreement 

 Schedule I 

Other Holders 
 Deerfield Private Design Fund III, L.P.

 780 Third Avenue 
 37th floor 

New York, NY 10017 
 F: (+1) 212-599-3075 

ABG II-EndoChoice Limited 
 c/o ABG II-EndoChoice Limited 

Kingston Chambers, PO Box 173, Road Town, 
 Tortola, British
Virgin Islands 
 Rock Springs Capital Master Fund LP 
 c/o
Rock Springs Capital 
 Attention: Alexandra Fulk and Evans Apeadu 

650 S. Exeter St., Suite 1070 
 Baltimore, MD 21202 

alex@rockspringscapital.com 
 evans@rockspringscapital.com

 Union Grove Partners Direct Venture Fund, LP 
 c/o Union
Grove Partners Direct Venture Fund, LP 
 301 W. Barbee Chapel Rd. 

Suite 220 
 Chapel Hill, NC 27517 

 Schedule 2 

Investor 
 Sequoia Capital U.S. Growth Fund V, L.P. 

c/o Sequoia Capital 
 2800 Sand Hill Road, Suite 101 

Menlo Park, CA 94025 

Attention:        Scott Carter 

Fax:                 (650) 854 2977

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