Document:

EX-10.18.3

 Exhibit 10.18.3 

OMNIBUS AMENDMENT AGREEMENT 
 This OMNIBUS AMENDMENT AGREEMENT (this “Amendment”) is entered into as of September 30, 2011, by and among Biocept, Inc., a
California corporation (the “Company”), and each of the entities identified on the signature pages hereto (each an “Investor” and collectively the “Investors”). 

RECITALS 
 A. The Company and the Investors are parties to that certain Note and Warrant Purchase Agreement, dated as of February 1, 2011, as amended on July 1, 2011 and August 1, 2011 (as
amended, the “Purchase Agreement”). 
 B. Pursuant to the Purchase
Agreement the Company issued the following Secured Convertible Promissory Notes (collectively, the “Outstanding Notes”): 
  

	 	(i)	Secured Convertible Promissory Note, dated February 1, 2011, issued to The Reiss Family GST Exempt Marital Deduction Trust, in the principal amount of $1,000,000;

  

	 	(ii)	Secured Convertible Promissory Note, dated March 1, 2011, issued to The Reiss Family Survivor’s Trust UDT dated December 19, 1988, in the principal
amount of $1,000,000; 

  

	 	(iii)	Secured Convertible Promissory Note, dated April 1, 2011, issued to The Reiss Family GST Exempt Marital Deduction Trust, in the principal amount of $1,000,000;

  

	 	(iv)	Secured Convertible Promissory Note, dated May 2, 2011, issued to The Reiss Family Survivor’s Trust UDT dated December 19, 1988, in the principal amount
of $1,000,000; 

  

	 	(v)	Secured Convertible Promissory Note, dated June 1, 2011, issued to The Reiss Family GST Exempt Marital Deduction Trust, in the principal amount of $1,000,000;

  

	 	(vi)	Secured Convertible Promissory Note, dated July 1, 2011, issued to The Reiss Family Survivor’s Trust UDT dated December 19, 1988, in the principal amount
of $1,000,000; 

  

	 	(vii)	Secured Convertible Promissory Note, dated August 1, 2011, issued to The Reiss Family Survivor’s Trust UDT dated December 19, 1988, in the principal
amount of $1,000,000; and 

  

	 	(viii)	Secured Convertible Promissory Note, dated September 12, 2011, issued to The Reiss Family Survivor’s Trust UDT dated December 19, 1988, in the principal
amount of $1,000,000. 

  
 1. 

 C. The Company and the Investors are parties to that certain Subordinated Security
Agreement, dated as of February 1, 2011 (the “Security Agreement”), pursuant to which the Company granted the Investors a subordinated security interest in certain assets of the Company as described therein. 

D. The Company and the Investors desire to amend the Outstanding Notes to provide that the Maturity Date (as defined in the
Outstanding Notes) of each Outstanding Note shall be December 31, 2012. 
 E. Section 14 of the Outstanding
Notes provides that each Outstanding Note may be amended with the written consent of the Company and each Investor. 
 F.
The Company is currently contemplating offering additional Secured Convertible Promissory Notes (collectively, the “Additional Notes”) to investors pursuant to the Purchase Agreement, and the
Company and the Investors desire to amend the Purchase Agreement to provide that the Additional Notes shall mature on December 31, 2012. 
 G. Section 6.7 of the Purchase Agreement may be amended with the written consent of the Company and the holders of at least a majority in interest of the outstanding Securities (as defined in
the Purchase Agreement). 
 H. To induce additional investors to purchase the Additional Notes, the Company and the
Investors desire to amend the Security Agreement to provide that purchasers of the Additional Notes shall be made a party to the Security Agreement, to grant such persons or entities a subordinated security interest in certain assets of the Company
as described therein. 
 I. Section 11.1 of the Security Agreement may be amended with the written consent of the
Company and each Secured Party (as defined in the Security Agreement). 
 AGREEMENT 

In exchange for other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, the parties agree as
follows: 
 1. Amendment to Outstanding Notes. Section 4.1 of each of the Outstanding Notes is hereby amended and
restated in its entirety as set forth below: 
 “4.1 Maturity Date. This Note and all unpaid
principal and accrued interest outstanding under this Note (the “Conversion Amount”) shall be due and payable on December 31, 2012 (the “Maturity Date”); provided, however,
that the Maturity Date (i) may be extended for two successive three month periods upon the written consent of the Investor and (ii) shall be accelerated upon the occurrence of an Event of Default (defined below).” 

2. Amendment to Purchase Agreement. Exhibit A of the Purchase Agreement shall be amended and restated to read in its entirety as
set forth on Exhibit A hereto. 

  
 2. 

 3. Amendment to Security Agreement. A new Section 11.5 is hereby added to the
Security Agreement as set forth below: 
 “11.5 Additional Parties. Notwithstanding anything to the
contrary contained herein, if the Company shall issue additional Notes pursuant to the Purchase Agreement, any purchaser of such Notes shall become a party to this Security Agreement by executing and delivering an additional counterpart signature
page to this Security Agreement and shall be deemed a “Secured Party” and a party hereunder.” 

4. Miscellaneous. 
 (a) This Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Facsimile or
electronic signatures shall be as effective as original signatures. 
 (b) Except as expressly modified by this
Amendment, the Purchase Agreement, the Outstanding Notes and the Security Agreement shall remain unmodified and in full force and effect. 
 (c) This Amendment shall be governed by and construed under the laws of the State of California as applied to agreements among California residents, made and to be performed entirely within the
State of California without giving effect to its conflicts of laws principles. 
 [REMAINDER OF
PAGE INTENTIONALLY LEFT BLANK] 

  
 3. 

 IN WITNESS WHEREOF, the parties hereto
have executed this OMNIBUS AMENDMENT AGREEMENT as of the date set forth in the first paragraph above. 

 

			
	 COMPANY:
  

BIOCEPT, INC.

a California corporation

		
	By:	 	/s/ William Kachioff
	 Name:
	 	William Kachioff
	 Title:
	 	CFO

 IN WITNESS WHEREOF, the parties hereto
have executed this OMNIBUS AMENDMENT AGREEMENT as of the date set forth in the first paragraph above. 

 

			
	INVESTORS:
	
	 THE REISS FAMILY GST EX MARITAL

DEDUCTION TRUST UDT 12/19/1988:

		
	 By:
	 	/s/ Claire K. T. Reiss
	 Name:
	 	CLAIRE K. T. REISS
	 Title:
	 	Trustee

  

			
	 THE REISS FAMILY SURVIVOR’S
TRUST
 UDT DATED DECEMBER 19, 1988:

		
	By:	 	/s/ Claire K. T. Reiss
	Name:	 	CLAIRE K. T. REISS
	Title:	 	Trustee

 EXHIBIT A 

FORM OF SECURED CONVERTIBLE PROMISSORY NOTEEX-10.18.4

 Exhibit 10.18.4 

BIOCEPT, INC. 
 AMENDMENT TO NOTE AND WARRANT PURCHASE AGREEMENT 
 This
AMENDMENT TO NOTE AND WARRANT PURCHASE AGREEMENT (this “Amendment”), amending the Note and Warrant
Purchase Agreement by and among BIOCEPT, INC., a California corporation (the “Company”), and the investors listed on the Schedule of Investors attached thereto (the
“Investors”), dated as of February 1, 2011, and amended as of July 1, 2011, August 1, 2011 and September 30, 2011 (as amended, the “Purchase Agreement”), is entered into as of
June 23, 2012. Capitalized terms used herein which are not defined herein shall have the definition ascribed to them in the Purchase Agreement. 
 RECITALS 
 WHEREAS, the Company and the Investors
have previously entered into the Purchase Agreement; 
 WHEREAS,
Section 6.7 of the Purchase Agreement provides that the Purchase Agreement may be amended with the written consent of (i) the Company and (ii) the holders of at least a majority in interest of the outstanding
Securities (the “Required Holders”); and  
 WHEREAS, the
undersigned constitute (i) the Company and (ii) the Required Holders. 
 AGREEMENT 

NOW, THEREFORE, in consideration of the foregoing and the promises and covenants
contained herein and in the Purchase Agreement, and for other good and valuable consideration, the receipt of which is hereby acknowledged, the parties hereto agree as follows: 
 1. Section 2.8 of the Purchase Agreement. The first sentence of Section 2.8 of the Purchase Agreement shall be amended and restated to read in its entirety as follows: 

“At any time prior to December 31, 2012, the Company may sell up to the balance of the authorized Notes and Warrants not sold at
the Seventh Closing, Sixth Closing, Fifth Closing, Fourth Closing, Third Closing, Second Closing and Initial Closing to such persons as may be approved by the Chief Executive Officer of the Company (the “Additional
Investors”).” 
 2. Effect of Amendment. Except as expressly modified by this Amendment, the
Purchase Agreement shall remain unmodified and in full force and effect. 
 3. Governing Law. This
Amendment shall be governed by and construed under the laws of the State of California as applied to agreements among California residents, made and to be performed entirely within the State of California without giving effect to its conflicts of
laws principles. 

 4. Counterparts. This Amendment may be executed in any number of counterparts
and signatures delivered by facsimile, each of which shall be deemed an original, but all of which together shall constitute one instrument. 
 [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

 IN WITNESS WHEREOF, the
parties have executed this AMENDMENT TO NOTE AND WARRANT PURCHASE AGREEMENT as of the date first written above.

  

									
	 COMPANY
  

BIOCEPT, INC.

a California corporation
	 		 	 INVESTORS:
  

Reiss Family GST Ex Marital Deduction Trust UDT 12/19/1988

					
	By:	 	/s/ David F. Hale	 		 	By:	 	/s/ Claire K. T. Reiss
	Name:	 	David F. Hale	 		 	Name:	 	CLAIRE K. T. REISS
	Title:	 	Executive Chairman	 		 	Title:	 	Trustee
				
		 		 		 	The Reiss Family Survivor’s Trust UDT dated December 19, 1988
					
		 		 		 	By:	 	/s/ Claire K. T. Reiss
		 		 		 	Name:	 	CLAIRE K. T. REISS
		 		 		 	Title:	 	Trustee

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