Document:

<PAGE>

                                                                   Exhibit 10.22

                                 AMENDMENT No. 6

                                       to

                        THE DEVELOPMENT AND MANUFACTURING
                               SERVICES AGREEMENT

                              Dated 08 January 2004

                                     Between

                               LONZA BIOLOGICS ***

                                       and

                          TRUBION PHARMACEUTICALS, INC.

<PAGE>

THIS AMENDMENT No. 6 ("Sixth Amendment") is made the 28th day of April 2005
BETWEEN

LONZA BIOLOGICS *** of *** (hereinafter referred to as "LB"), and

TRUBION PHARMACEUTICALS, INC., of 2401 4th Avenue, Suite 1050, Seattle, WA
98121, USA (herein after referred to as the "Customer")

WHEREAS

A.   LB and the Customer entered into a development and manufacturing services
     agreement ("the Agreement") dated 08 January 2004, pursuant to which LB
     agreed to provide Services to the Customer, and,

B.   The Customer now wishes LB to perform additional services under the
     Agreement, and,

C.   LB is willing to perform such additional services on the terms set out in
     the Agreement, and

D.   The parties wish to amend the Agreement in accordance with Clause 13.5
     thereto.

NOW THEREFORE IT IS HEREBY AGREED as follows:

     1. TWO NEW STAGES, STAGES 25 AND 26, SHALL BE ADDED TO SCHEDULE 2 OF THE
AGREEMENT TO READ AS FOLLOWS:

     "STAGE 25 ***

     BACKGROUND

     ***

     25.1 OBJECTIVES

          ***.

     25.2 ACTIVITIES

          ***

     25.3 DELIVERABLES

          25.3.1 A copy of the report of activities as prepared in activity
               25.2.11.

     25.4 TIMESCALE

     Stage 25 can commence upon signature of this Amendment and it is estimated
that Stage 25 will be complete approximately *** from commencement.

<PAGE>

     STAGE 26 ***

     BACKGROUND

     ***

     26.1 OBJECTIVES

          ***

     26.2 ACTIVITIES

          ***

     26.3 DELIVERABLES

          26.3.1 A copy of the sampling plan prepared in activity 26.2.1.

          26.3.2 *** obtained in activity 26.2.12.

          26.3.3 Samples from the development study as agreed in activity 26.2.1
               and 26.2.14.

          26.3.4 A copy of the report of activities as prepared in activity
               26.2.15.

     26.4 TIMESCALE

     Stage 26 can commence upon signature of this Amendment and it is estimated
that Stage 26 will be complete approximately *** from commencement."

     SCHEDULE 3 TO THE AGREEMENT SHALL BE AMENDED TO INCLUDE PROVISION FOR
PAYMENT FOR THE ABOVE MENTIONED ADDITIONAL SERVICES, AS SET OUT BELOW HERETO.
INVOICES FOR THESE ADDITIONAL SERVICES SHALL BE ISSUED, AND CUSTOMER PAYMENTS
SHALL BE MADE, IN ***:

     "1.  PRICE

     ***

     2.   PAYMENT

     FOR STAGE 25

     *** upon commencement of Stage 25.

     *** upon completion of Stage 25.

     FOR STAGE 26

     *** upon commencement of Stage 26.

                                       -2-

<PAGE>

     *** upon completion of Stage 26."

     SAVE AS HEREIN PROVIDED ALL OTHER TERMS AND CONDITIONS OF THE AGREEMENT
SHALL REMAIN IN FULL FORCE AND EFFECT.

     AS WITNESS the hands of the duly authorised representatives of the parties
hereto the day and year first above written.

Signed for and on behalf of                                ***
                                        ----------------------------------------
LONZA BIOLOGICS ***
                                                           ***
                                        ----------------------------------------
                                                          TITLE

Signed for and on behalf of             /s/ Kendall M. Mohler
TUBION PHARMACEUTICALS, INC.            ----------------------------------------
                                        Senior VP Research & Development
                                                      TITLE

                                       -3-<PAGE>

                                                                   Exhibit 10.23
                                 AMENDMENT No. 7

                                       to

                        THE DEVELOPMENT AND MANUFACTURING
                               SERVICES AGREEMENT

                              Dated 08 January 2004

                                     Between

                               LONZA BIOLOGICS ***

                                       and

                          TRUBION PHARMACEUTICALS, INC.

<PAGE>

THIS AMENDMENT No. 7 ("Seventh Amendment") is made the 12th day of May 2005

BETWEEN

LONZA BIOLOGICS *** of *** (hereinafter referred to as "LB"), and

TRUBION PHARMACEUTICALS, INC., of 2401 4th Avenue, Suite 1050, Seattle, WA
98121, USA (herein after referred to as the "Customer")

WHEREAS

A.   LB and the Customer entered into a development and manufacturing services
     agreement ("the Agreement") dated 08 January 2004, pursuant to which LB
     agreed to provide Services to the Customer, and,

B.   The Customer now wishes LB to perform additional services under the
     Agreement, and,

C.   LB is willing to perform such additional services on the terms set out in
     the Agreement, and,

D.   The parties wish to amend the Agreement in accordance with Clause 13.5
     thereto.

NOW THEREFORE IT IS HEREBY AGREED as follows:

     1.   TWO NEW STAGES, STAGES 27 AND 28 SHALL BE ADDED TO SCHEDULE 2 OF THE
          AGREEMENT TO READ AS FOLLOWS:

     "STAGE 27 ***

     BACKGROUND

     ***

     27.1 OBJECTIVES

     ***

     27.2 ACTIVITIES

     ***

     27.3 DELIVERABLES

          27.3.1 A copy of the *** prepared in activity 27.2.1.

          27.3.2 Appropriate samples from the *** as agreed in activity 27.2.1.

          27.3.3 A copy of the *** study report prepared in activity 27.2.12.

<PAGE>

          27.3.4 Remaining Product (from activity 27.2.16) and/or clarified
culture supernatant (from activity 27.2.15).

     27.4 TIMESCALE

          Stage 27 can commence upon receipt of the *** at LB and it is
estimated that Stage 27 will be complete approximately *** from the
commencement.

     STAGE 28 ***

     BACKGROUND

     ***

     28.1 OBJECTIVES

     ***

     28.2 ACTIVITIES

     ***

     28.3 DELIVERABLES

          28.3.1 Information package containing the documentation necessary to
          ***.

          28.3.2 Assistance in establishment and qualification ***.

     28.4 TIMESCALE

     Stage 28 can commence upon signature of this Amendment No. 7 and is
estimated to be complete either *** from commencement or *** after LB's visit to
*** Facility, whichever the sooner.

     SCHEDULE 3 TO THE AGREEMENT SHALL BE AMENDED TO INCLUDE PROVISION FOR
PAYMENT FOR THE ABOVE MENTIONED ADDITIONAL SERVICES, AS SET OUT BELOW. INVOICES
FOR THESE ADDITIONAL SERVICES SHALL BE ISSUED, AND CUSTOMER PAYMENTS SHALL BE
MADE, IN ***:

     "1.  PRICE

     ***

     2. PAYMENT

     FOR STAGE 27 - ***

     ***  upon commencement of ***

                                      -2-

<PAGE>

     ***  upon completion of ***

     FOR STAGE 27 - ***

     ***  upon commencement ***

     ***  upon completion ***

     FOR STAGE 28 - ***

     ***  upon commencement of Stage 28.

     ***  upon completion (no later than 3 months from commencement)

     FOR STAGE 28 - ***

     ***  payable one week following the visit to *** facility

     SAVE AS HEREIN PROVIDED ALL OTHER TERMS AND CONDITIONS OF THE AGREEMENT
SHALL REMAIN IN FULL FORCE AND EFFECT.

     AS WITNESS the hands of the duly authorised representatives of the parties
hereto the day and year first above written.

Signed for and on behalf of             ***
LONZA BIOLOGICS ***                     ----------------------------------------

                                        ***
                                        ----------------------------------------
                                        TITLE

Signed for and on behalf of             /s/ Peter A. Thompson
                                        ----------------------------------------
TUBION PHARMACEUTICALS, INC.            Chief Executive Officer
                                        TITLE

                                      -3-<PAGE>

                                                                   Exhibit 10.24

                                 AMENDMENT No. 8

                                       to

                        THE DEVELOPMENT AND MANUFACTURING
                               SERVICES AGREEMENT

                              Dated 08 January 2004

                                     Between

                               LONZA BIOLOGICS ***

                                       and

                          TRUBION PHARMACEUTICALS, INC.

<PAGE>

     THIS AMENDMENT No. 8 ("Eighth Amendment") is made the 5th day of October
2005

     BETWEEN

     LONZA BIOLOGICS *** of *** (hereinafter referred to as "LB"), and

     TRUBION PHARMACEUTICALS, INC., of 2401 4th Avenue, Suite 1050, Seattle, WA
98121, USA (herein after referred to as the "Customer")

     WHEREAS

     A.   LB and the Customer entered into a development and manufacturing
          services agreement ("the Agreement") dated 08 January 2004, pursuant
          to which LB agreed to provide Services to the Customer, and,

     B.   The Customer now wishes LB to perform additional services under the
          Agreement, and,

     C.   LB is willing to perform such additional services on the terms set out
          in the Agreement, and

     D.   The parties wish to amend the Agreement in accordance with Clause 13.5
          thereto.

     NOW THEREFORE IT IS HEREBY AGREED as follows:

     1.0 STAGE 26 IN SCHEDULE 2 OF THE AGREEMENT SHALL BE DELETED IN ITS
ENTIRETY AND REPLACED WITH THE FOLLOWING:

     "STAGE 26 ***

     BACKGROUND

     ***

     26.1 OBJECTIVES

     ***

     26.2 ACTIVITIES

     ***

     26.3 DELIVERABLES

          26.3.1 A copy of the sampling plan prepared in activity 26.2.1.

          26.3.2 Samples from the development study as agreed in activity 26.2.1
     and 26.2.14

<PAGE>

          26.3.3 A copy of the experimental data as prepared in activity 26.2.11

     26.4 TIMESCALE

     Stage 26 commenced upon signature of Amendment 6 dated 28th April 2005. It
is estimated that Stage 26 will be complete approximately *** from
commencement."

     2.0 TWO NEW STAGES, STAGES 29 AND 30, SHALL BE ADDED TO SCHEDULE 2 OF THE
AGREEMENT TO READ AS FOLLOWS:

     "STAGE 29 ***

     BACKGROUND

     ***

     29.1 OBJECTIVES

     ***

     29.2 ACTIVITIES

     ***

     29.3 DELIVERABLES

          29.3.1 A copy of the experimental data as prepared in activity
     29.2.11.

     29.4 TIMESCALE

     Stage 29 commenced at Customer's request in June 2005.

     It is estimated that Stage 29 will be complete approximately *** from
commencement.

     STAGE 30 ***

     BACKGROUND

     ***

     30.1 OBJECTIVES

     ***

     30.2 ACTIVITIES

     ***

                                       -2-

<PAGE>

     30.3 DELIVERABLES

          30.3.1 A copy of the summary report of activities as prepared in
     activity 30.2.7

     30.4 TIMESCALE

     Stage 30 commenced at Customer's request ***. It is estimated that Stage 30
will be complete approximately *** from commencement."

                                       -3-

<PAGE>

     SCHEDULE 3 TO THE AGREEMENT SHALL BE AMENDED TO INCLUDE PROVISION FOR
PAYMENT FOR THE ABOVE MENTIONED ADDITIONAL SERVICES, AS SET OUT BELOW HERETO.
INVOICES FOR THESE ADDITIONAL SERVICES SHALL BE ISSUED, AND CUSTOMER PAYMENTS
SHALL BE MADE, IN * * *:

     "1. PRICE

     ***

     2. PAYMENT

     FOR STAGE 26

     *** received upon commencement of Stage 26
     *** upon completion of Stage 26.

     FOR STAGE 30

     *** upon commencement of Stage 30.
     *** upon completion of Stage 30."

                                       -4-

<PAGE>

     SAVE AS HEREIN PROVIDED ALL OTHER TERMS AND CONDITIONS OF THE AGREEMENT
SHALL REMAIN IN FULL FORCE AND EFFECT.

     AS WITNESS the hands of the duly authorised representatives of the parties
hereto the day and year first above written.

Signed for and on behalf of             ***
LONZA BIOLOGICS ***                     ----------------------------------------

                                        ***
                                        ----------------------------------------
                                        TITLE

Signed for and on behalf of             /s/ Kendall M. Mohler
TRUBION PHARMACEUTICALS, INC            ----------------------------------------
                                        Senior VP Research & Development
                                        TITLE

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00104-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00104-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00104-of-00352.parquet"}]]