Document:

Exhibit
4.1

FIRST AMENDMENT

FIRST AMENDMENT (this “Amendment”), dated as of
February 11, 2005, to (i) Credit Agreement dated as of April 7, 2004 (the “Credit
Agreement”) among VWR INTERNATIONAL, INC. (as successor in interest to CDRV
Acquisition Corporation) (the “Parent Borrower”), the Foreign Subsidiary
Borrowers from time to time parties to the Credit Agreement, the lenders from
time to time party to the Credit Agreement (each a “Lender” and, collectively,
the “Lenders”), DEUTSCHE BANK AG NEW YORK BRANCH, as Administrative
Agent (in such capacity, the “Administrative Agent”), CITICORP NORTH
AMERICA, INC., as Syndication Agent, and BANK OF AMERICA, N.A., BNP PARIBAS,
and BARCLAYS BANK PLC, as Documentation Agents, and (ii) Guarantee and
Collateral Agreement, dated as of April 7, 2004 (the “Guarantee and
Collateral Agreement”), among CDRV HOLDINGS, INC. (“Holdings”), the
Parent Borrower, the Foreign Subsidiary Borrowers from time to time parties to
the Guarantee and Collateral Agreement, VWR, INC., SCIENCE KIT, INC., and WARD’S
NATURAL SCIENCE ESTABLISHMENT (“Wards” and, together with VWR, Inc. and
Science Kit, Inc., the “Subsidiary Guarantors”) in favor of the
Administrative Agent for the benefit of the Lenders.  Unless otherwise defined herein, all capitalized
terms used herein and defined in the Credit Agreement referred to below are
used herein as therein defined.

W
I T N E S S E T H :

WHEREAS, the Parent Borrower, the Lenders and the
Administrative Agent have entered into the Credit Agreement;

WHEREAS, Holdings, the Parent Borrower, and the
Subsidiary Guarantors have entered into the Guarantee and Collateral Agreement;
and

WHEREAS, subject to the terms and conditions set forth
below, the parties hereto wish to amend certain provisions of the Credit
Agreement and the Guarantee and Collateral Agreement as provided herein;

NOW, THEREFORE, it is agreed;

A.            Amendments
to the Credit Agreement

1.             Section 1.1 of the
Credit Agreement is hereby amended by inserting the following new definition in
the appropriate alphabetical order:

““Cash Pooling Arrangement” means a deposit
account arrangement among a single depository institution, the Parent Borrower
and one or more Foreign Subsidiaries involving the pooling of cash deposits in
and overdrafts in respect of one or more deposit accounts (each located outside
of the United States and any States and territories thereof) with such
institution by the Parent Borrower and such Foreign Subsidiaries for cash
management purposes.”

2.             Section 8.2 of the
Credit Agreement is hereby amended by (i) deleting the text “and” appearing at
the end of clause (q) thereof, (ii) deleting clause (r) in its entirety and
(iii) inserting the following new clauses (r) and (s) immediately following the
end of clause (q):

“(r) Indebtedness not otherwise permitted by the
preceding clauses, or the following clause, of this subsection 8.2 not
exceeding $25,000,000 in aggregate principal amount at any one time
outstanding; and

(s) overdrafts in respect of any deposit accounts
subject to a Cash Pooling Arrangement; provided that the total amount of
all deposits subject to any such Cash Pooling Arrangement at all times equals
or exceeds the total amount of overdrafts that may be subject to such Cash
Pooling Arrangements.”

3.             Section 8.3 of the
Credit Agreement is hereby amended by (i) deleting the text “and”
appearing at the end of clause (p) thereof, (ii) deleting the period
at the end of clause (q) and inserting the text “; and” in lieu thereof
and (iii) inserting the following new clause (r) immediately following
the end of clause (q):

“(r) Liens on cash deposits of the Parent Borrower and
Foreign Subsidiaries subject to a Cash Pooling Arrangement or otherwise over
bank accounts of the Parent Borrower and Foreign Subsidiaries maintained as
part of the Cash Pooling Arrangements, in each case securing liabilities for
overdrafts of the Parent Borrower and Foreign Subsidiaries participating in
such Cash Pooling Arrangement.”

4.             Section 8.4 of the
Credit Agreement is hereby amended by (i) deleting the text “and”
appearing at the end of clause (o) thereof, (ii) deleting the period at the end
of clause (p) and inserting the text “; and” in lieu thereof and
(iii) inserting the following new clause (q) immediately following
the end of clause (p):

“(q) Guarantee Obligations in respect of Indebtedness
permitted pursuant to Section 8.2(s).”

5.             Section 8.9 of the
Credit Agreement is hereby amended by (i) deleting the text “and”
appearing at the end of clause (o) thereof, (ii) deleting
clause (p) in its entirety 

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and (iii) inserting
the following new clauses (p) and (q) immediately following the end of
clause (o):

“(p) Investments not otherwise permitted by the
preceding clauses, or the following clause, of this subsection 8.9 not to
exceed in the aggregate $15,000,000; and

(q)           deposits
made by the Parent Borrower and Foreign Subsidiaries in Cash Pooling
Arrangements.”

B.            Amendments
to the Guarantee and Collateral Agreement

1.             Section 5.2.13 of
the Guarantee and Collateral Agreement is hereby amended by deleting the first sentence
thereof in its entirety and inserting the following new first sentence in lieu
thereof:

“No Grantor (other than any Foreign Subsidiary of the
Parent Borrower) maintains, or at any time after the date of this Agreement
shall establish or maintain, any demand, time, savings, passbook or similar
account, except for such accounts maintained with a bank (as defined in
Section 9-102 of the Code) whose jurisdiction (determined in accordance
with Section 9-304 of the Code) is within the United States, any State
thereof or the District of Columbia, other than such accounts whose
jurisdiction is not within the United States, any State thereof or the District
of Columbia (x) which have an aggregate balance at any time outstanding of
less than $10,000,000, (y) any collection accounts maintained for the
purpose of collecting Accounts Receivable with respect to any such jurisdiction
or (z) maintained by the Parent Borrower in connection with a Cash Pooling
Arrangement; provided that to the extent the Parent Borrower maintains
any accounts with a bank in connection with a Cash Pooling Arrangement either
(a) the Parent Borrower shall maintain no other accounts with such bank,
or (b) that bank shall have waived all rights of setoff, banker’s liens
and other liens over such other accounts not part of the Cash Pooling
Arrangement.”

C.            Miscellaneous
Provisions

1.             In order to induce
the Lenders to enter into this Amendment, the Parent Borrower hereby represents
and warrants to each of the Lenders that (i) all of the representations
and warranties contained in the Credit Agreement and in the other Loan
Documents are true and correct in all material respects on and as of the First
Amendment Effective Date, after giving effect to this Amendment (unless such
representations and warranties relate to a specific earlier date, in which case
such representations and warranties shall be true and correct as of such
earlier date), and (ii) there exists no 

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Default or
Event of Default on the First Amendment Effective Date, after giving effect to
this Amendment.

2.             This Amendment is
limited as specified and shall not constitute a modification, acceptance or
waiver of any other provision of the Credit Agreement, the Guarantee and
Collateral Agreement or any other Loan Document.

3.             This Amendment may
be executed in any number of counterparts, each of which counterparts when
executed and delivered shall be an original, but all of which shall together
constitute one and the same instrument. 
A complete set of counterparts executed by all the parties hereto shall
be lodged with the Parent Borrower and the Administrative Agent.

4.             THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF THE
PARTIES HEREUNDER SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAW
OF THE STATE OF NEW YORK.

5.             This Amendment
shall become effective on the date (the “First Amendment Effective Date”)
when Holdings, the Parent Borrower, the Subsidiary Guarantors and the Required
Lenders shall have signed a counterpart hereof (whether the same or different
counterparts) and shall have delivered (which delivery may be by way of
telecopier or other electronic means) the same to the Administrative Agent.

6.             From and after the
First Amendment Effective Date, (i) all references in the Credit Agreement
and in the other Loan Documents to the Credit Agreement shall be deemed to be
references to the Credit Agreement as modified hereby and (ii) all
references in the Guarantee and Collateral Agreement and in the other Loan
Documents to the Guarantee and Collateral Agreement shall be deemed to be
references to the Guarantee and Collateral Agreement as modified hereby.

*     *     *

 4

 

IN WITNESS WHEREOF, the undersigned have caused this
Amendment to be duly executed and delivered as of the date first above written.

	
  

  	
  CDRV HOLDINGS, INC.

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Stephen J. Kunst

  	
   

  
	
   

  	
   

  	
  Name: Stephen J. Kunst

  	
   

  
	
   

  	
   

  	
  Title: Secretary

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  VWR INTERNATIONAL, INC.

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Stephen J. Kunst

  	
   

  
	
   

  	
   

  	
  Name: Stephen J. Kunst

  	
   

  
	
   

  	
   

  	
  Title: Secretary

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  VWR, INC.

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Douglas J. Pitts

  	
   

  
	
   

  	
   

  	
  Name: Douglas J. Pitts

  	
   

  
	
   

  	
   

  	
  Title: Assistant Secretary

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  SCIENCE KIT, INC.

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Deborah A. Corr

  	
   

  
	
   

  	
   

  	
  Name: Deborah A. Corr 

  	
   

  
	
   

  	
   

  	
  Title: Secretary

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  WARD’S NATURAL SCIENCE ESTABLISHMENT, INC.

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Deborah A. Corr

  	
   

  
	
   

  	
   

  	
  Name: Deborah A. Corr 

  	
   

  
	
   

  	
   

  	
  Title: Secretary

  	
   

  

 

 

	
  

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  DEUTSCHE BANK AG NEW YORK BRANCH, Individually and
  as Administrative Agent

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Diane F. Rolfe

  	
   

  
	
   

  	
   

  	
  Name: Diane F. Rolfe

  	
   

  
	
   

  	
   

  	
  Title: Vice President

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Scottye Lindsey

  	
   

  
	
   

  	
   

  	
  Name: Scottye Lindsey

  	
   

  
	
   

  	
   

  	
  Title: Director

  	
   

  

 

 

	
  

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  BANK OF AMERICA, N.A.

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Suzanne Chomiczewski

  	
   

  
	
   

  	
   

  	
  Name: Suzanne Chomiczewski

  	
   

  
	
   

  	
   

  	
  Title: Vice President

  	
   

  

 

 

	
  

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  BARCLAYS BANK PLC

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ David Barton

  	
   

  
	
   

  	
   

  	
  Name: David Barton

  	
   

  
	
   

  	
   

  	
  Title: Manager

  	
   

  

 

 

	
  

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  BNP PARIBAS

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Gregg Bonardi

  	
   

  
	
   

  	
   

  	
  Name: Gregg Bonardi

  	
   

  
	
   

  	
   

  	
  Title: Director

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Stephanie Rogers

  	
   

  
	
   

  	
   

  	
  Name: Stephanie Rogers

  	
   

  
	
   

  	
   

  	
  Title: Vice President

  	
   

  

 

 

	
  

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  CITICORP NORTH AMERICA, INC.

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ C.P. Mahon

  	
   

  
	
   

  	
   

  	
  Name: C.P. Mahon

  	
   

  
	
   

  	
   

  	
  Title: Vice PresidentExhibit 4.2

SECOND AMENDMENT

SECOND AMENDMENT (this “Amendment”), dated as
of August 18, 2006, to the Credit Agreement, dated as of April 7, 2004 (as
amended, supplemented, waived or otherwise modified prior to the date hereof,
the “Credit Agreement”), among VWR INTERNATIONAL, INC. (as successor in
interest to CDRV Acquisition Corporation) (the “Parent Borrower”), the
Foreign Subsidiary Borrowers from time to time parties to the Credit Agreement,
the lenders from time to time party to the Credit Agreement (each a “Lender”
and, collectively, the “Lenders”), DEUTSCHE BANK AG NEW YORK BRANCH, as
Administrative Agent (in such capacity, the “Administrative Agent”),
CITICORP NORTH AMERICA, INC., as Syndication Agent, and BANK OF AMERICA, N.A.,
BNP PARIBAS, and BARCLAYS BANK PLC, as Documentation Agents.  Unless otherwise defined herein, all
capitalized terms used herein and defined in the Credit Agreement referred to
below are used herein as therein defined.

W I T N E S S E T H :

WHEREAS, the Parent Borrower, the Lenders and the
Administrative Agent have entered into the Credit Agreement; and

WHEREAS, subject to the terms and conditions set forth
below, the parties hereto wish to amend certain provisions of the Credit
Agreement as provided herein;

NOW, THEREFORE, it is agreed;

A.                                   Amendments
to the Credit Agreement

1.             Section 1.1 of the
Credit Agreement is hereby amended by inserting the following new definitions
in the appropriate alphabetical order:

““Second Amendment”:
the Second Amendment to this Agreement, dated as of August ___, 2006, among the
Parent Borrower, the Lenders and the Administrative Agent.

“Second Amendment
Effective Date”: as defined in the Second Amendment.”

2.             Section 8.10(b) of
the Credit Agreement is hereby amended by (x) deleting clause (iii) in its
entirety and (y) inserting the following new clause (iii) in lieu thereof:

“(iii)        cash
and other property (excluding cash and other property covered under clauses
(i), (ii) and (iv) of this subsection 8.10(b)) and Indebtedness (whether
incurred or assumed) in an aggregate amount which, when 

 

aggregated with all other
amounts of cash and such other property paid for acquisitions, and Indebtedness
incurred or assumed, in each case in reliance on this clause (iii), does not
exceed in the aggregate (x) with respect to acquisitions made prior to the
Second Amendment Effective Date, $60,000,000 and (y) with respect to
acquisitions made on or after the Second Amendment Effective Date, $60,000,000;
provided that such amount in the immediately preceding clause (y) shall
be increased by an amount equal to $5,000,000 on each anniversary of the
Closing Date following the Second Amendment Effective Date, so long as no
Default or Event of Default shall have occurred and be continuing on any date
on which such amount is to be increased; and/or”

B.                                     Miscellaneous
Provisions

1.             In order to induce
the Lenders to enter into this Amendment, the Parent Borrower hereby represents
and warrants to each of the Lenders that (i) all of the representations and
warranties contained in the Credit Agreement and in the other Loan Documents
are true and correct in all material respects on and as of the Second Amendment
Effective Date, after giving effect to this Amendment (unless such
representations and warranties relate to a specific earlier date, in which case
such representations and warranties shall be true and correct as of such
earlier date), and (ii) there exists no Default or Event of Default on the
Second Amendment Effective Date, after giving effect to this Amendment.

2.             This Amendment is
limited as specified and shall not constitute a modification, acceptance or
waiver of any other provision of the Credit Agreement, the Guarantee and
Collateral Agreement or any other Loan Document.

3.             This Amendment may
be executed in any number of counterparts, each of which counterparts when
executed and delivered shall be an original, but all of which shall together
constitute one and the same instrument. 
A complete set of counterparts executed by all the parties hereto shall
be lodged with the Parent Borrower and the Administrative Agent.

4.             THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER
SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAW OF THE STATE OF
NEW YORK.

5.             This Amendment
shall become effective on the date (the “Second Amendment Effective Date”)
when the Parent Borrower and the Required Lenders shall have signed a
counterpart hereof (whether the same or different counterparts) and shall have
delivered (which delivery may be by way of telecopier or other electronic
means) the same to the Administrative Agent.

 2
 

 

6.             From
and after the Second Amendment Effective Date, all references in the Credit
Agreement and in the other Loan Documents to the Credit Agreement shall be
deemed to be references to the Credit Agreement as modified hereby.

*    *    *

 

 3

IN WITNESS WHEREOF, the undersigned have caused this
Amendment to be duly executed and delivered as of the date first above written.

	
  

  	
  VWR INTERNATIONAL, INC.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Scott G. Smith

  
	
   

  	
   

  	
  Name:

  	
  Scott G. Smith

  
	
   

  	
   

  	
  Title:

  	
  Vice President & Corporate Treasurer

  

 

 

 

	
  

  	
  DEUTSCHE BANK AG NEW YORK BRANCH:

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  DB Services New Jersey, Inc.

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Deirdre Whorton

  
	
   

  	
   

  	
  Name:

  	
  Deirdre Whorton

  
	
   

  	
   

  	
  Title:

  	
  Assistant Vice President

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Deborah O’Keeffe

  
	
   

  	
   

  	
  Name:

  	
  Deborah O’Keeffe

  
	
   

  	
   

  	
  Title:

  	
  Vice President

  
					

 

 

 

	
  

  	
  BANK OF AMERICA, N.A.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Alysa Trakas

  
	
   

  	
   

  	
  Name:

  	
  Alysa Trakas

  
	
   

  	
   

  	
  Title:

  	
  Vice President

  

 

 

 

	
  

  	
  BNP PARIBAS

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Gregg Bonardi

  
	
   

  	
   

  	
  Name:

  	
  Gregg Bonardi

  
	
   

  	
   

  	
  Title:

  	
  Director

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ Ola Anderssen

  
	
   

  	
   

  	
  Name:

  	
  Ola Anderssen

  
	
   

  	
   

  	
  Title:

  	
  Director

  

 

 

 

	
  

  	
  BARCLAYS BANK PLC

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ David Barton

  
	
   

  	
   

  	
  Name:

  	
  David Barton

  
	
   

  	
   

  	
  Title:

  	
  Associate Director

  

 

 

 

	
  

  	
  CITICORP NORTH AMERICA, INC.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ C.P. Mahon

  
	
   

  	
   

  	
  Name:

  	
  C.P. Mahon

  
	
   

  	
   

  	
  Title:

  	
  Vice President

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