Document:

Fourth Amendment to Loan and Security Agreement

FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT

THIS FOURTH AMENDMENT TO LOAN AND SECURITY
AGREEMENT (this "Amendment") is made and entered into this 1st day of April, 2004, by and between
NATIONAL VISION, INC., 
a
Georgia corporation (hereinafter referred to as "Borrower") with its chief executive office and principal place of business at 296 Grayson Highway, Lawrenceville, Georgia 30045-5737, and 
FLEET CAPITAL CORPORATION, 
a Rhode Island corporation (hereinafter referred to as "Lender") with an office at 300 Galleria Parkway, N.W., Suite 800, Atlanta, Georgia
30339.

Recitals:

Lender and Borrower are parties to a certain Loan and Security Agreement dated May 30, 2001, as amended by that certain First Amendment to Loan and Security Agreement
dated as of December 2 1, 2001, but effective as of June 30, 2001, that certain letter agreement dated as of December 28,2002 and that certain Second Amendment to Loan and Security Agreement dated December 19, 2003 (as amended, the "Loan
Agreement"), pursuant to which Lender has made certain revolving credit loans and other financial accommodations to Borrower.

The parties desire to amend the Loan Agreement as hereinafter set
forth.

NOW, THEREFORE, for TEN DOLLARS ($10.00) in hand paid and other good and valuable consideration, the receipt and sufficiency of which are hereby severally
acknowledged, the parties hereto, intending to be legally bound hereby, agree as follows: 

1.        
Definitions. 	
All capitalized
terms used in this Amendment, unless otherwise defined herein, shall have the meaning ascribed to such terms in the Loan Agreement.

2.        
Amendments to Loan Agreement. 	
The Loan Agreement is hereby amended as follows:

 (a)        By deleting Section 6.6 of the Loan Agreement and by substituting in lieu thereof the
following:

 

 

6.6        

Lien Perfection; Further Assurances. 
Promptly after Lender's request therefor, Borrower shall execute or cause to be executed and deliver to Lender such instruments (including the Eyecare Professional Notes), assignments, title certificates or other documents as are
necessary under the UCC or other Applicable Law (including any motor vehicle certificate of title act) to perfect (or continue the perfection of) Lender's Lien upon the Collateral and shall take such other action as may be requested by Lender to
give effect to or carry out the intent and purposes of this Agreement. Unless prohibited by Applicable Law, Borrower hereby authorizes Lender to execute and file any such financing statement on Borrower's behalf. The parties agree that a carbon, photographic or other
reproduction of this Agreement shall be sufficient 
as a financing statement and may be filed in any appropriate office in lieu
thereof. Unless prohibited by Applicable Law, Borrower hereby irrevocably authorizes Lender to execute and file in any jurisdiction any financing statements or amendments thereto on Borrower's behalf, including, without limitation, financing
statements that indicate the Collateral (i) as all assets or all personal property of Borrower or words of similar effect, or
(ii) as being of an equal or lesser scope, or with greater or lesser detail, than as set forth in this 
Section 6. 
Borrower also hereby ratifies its authorization for Lender to have
filed in any jurisdiction any like financing statements or amendments thereto if filed prior to the date hereof.

(b)        By deleting clause (ii) of Section 9.2.2 of the Loan Agreement and by substituting in lieu thereof the following:

(ii)        (a) to independent eyecare professionals located in Host Locations occupied under the Fred Meyer Agreement in the Ordinary Course of Business, which loans or
other advances are in the amount of the services rendered by such professionals to Borrower's customers and are repaid by such professionals to Borrower as the result of the collection by Borrower of such sums from such customers (or Third Party
Payors) on behalf of such professionals; or (b) to independent eyecare professionals located in Host Locations in an aggregate
amount not exceeding $540,000, which loans are made to facilitate such professionals' purchase of Software or hardware for the processing of managed care billings and are evidenced by Eyecare Professional Notes, provided that, no Default or Event of
Default exists at the time of, or immediately after, the making of each such loan or other advance; and

(c)        By deleting Section 9.2.14 of the Loan Agreement and by substituting
in lieu thereof the following:

     9.2.14       
Leases. Become a lessee under any operating lease (other than a lease under which Borrower
or any of the Subsidiaries is lessor or the Host Licensor Agreements) of Property if the aggregate Rentals payable during any current or future period of 12 consecutive months under the lease in question and all other leases under which Borrower or any of the Subsidiaries is then lessee would exceed $800,000. The term "Rentals" means, as of the date of
determination, all payments which the lessee is required to make by the terms of any lease.

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(d)        By adding the following definition of "Eyecare Professional Note" to Appendix A to the Loan Agreement in proper alphabetical sequence which reads as follows:

Eyecare Professional Note -a promissory
note made to the order of Borrower by an independent eyecare professional located in a Host Location, which evidences the amount of any loan or other advance made by Borrower to such professional and which provides that the principal amount of such
loan or advance shall be paid in full within five (5) months after the date such loan or advance is made.

(e)        By deleting the definition of "Host
Licensor Agreements" in Appendix A to the Loan Agreement and by substituting in
lieu thereof the following: 

Host Licensor Agreements - the Wal-Mart
Agreement, the Fred Meyer Agreement, the Military Agreements, and any other like agreement entered into by Borrower or any Subsidiary, on the one hand, and any Person, on the other hand, pursuant to which Borrower or the Subsidiary is licensed or
otherwise permitted to occupy and operate, within the retail space of such Person, (i) a retail vision center, (ii) an optometric clinic, or (iii) an outlet engaged in the retail sale of home medical equipment and related goods and services.

3.       
Consents.  Lender hereby
consents to (a) Borrower's formation of a new Subsidiary, Independent Living Company, LLC, a Georgia limited liability company (the "New Subsidiary") for the purpose of operating not in excess of five home healthcare equipment stores within the
retail stores of Wal-Mart and Lender further consents to Borrower's investment ofnot more than $500,000 in the New Subsidiary; provided that (i) the New Subsidiary is not a Managed Care Subsidiary, (ii) the New Subsidiary is formed no later than
June 30,2004, (iii) no Default or Event of Default exists at the time of, or immediately after, the formation of the New Subsidiary, and (iv) the Equity Interests of Borrower in the New Subsidiary are pledged to Lender as security for the Obligations pursuant to a Pledge Agreement and the certificates evidencing such Equity Interests are delivered to Lender
along with Irrevocable Powers and Assignments; (b) Borrower's payment of an amount, not to exceed $25,000 in the aggregate, to three former officers of Borrower in connection with the termination of such officers' employment with Borrower and
the redemption of such officers' Equity Interests in Borrower; and (c) the dissolution of Midwest and Vista Optical Express, Inc., a Georgia corporation. Borrower agrees to deliver to Lender such information and documents as Lender may request from
time to time relating to the New Subsidiary. 

4.        Ratification and Reaffirmation. Borrower hereby ratifies and reaffirms the Obligations, each of the Loan Documents, and all of Borrower's covenants, duties, indebtedness and liabilities under the Loan Documents.

5.        Acknowledgments and Stipulations. Borrower acknowledges and stipulates that the Loan Agreement and the other Loan Documents executed by Borrower are legal, valid and binding obligations of Borrower that are enforceable against Borrower in accordance with the terms
thereof; all of the Obligations are owing and payable without defense, offset or counterclaim (and to the

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extent there exists any such defense, offset or counterclaim on the date hereof, the same is hereby waived by Borrower); the security interests and liens granted by Borrower in favor of Lender are duly perfected, first priority security interests and liens. 

6.        
Representations and Warranties. 	
Borrower represents and warrants to Lender, to induce Lender to enter into this Amendment, that no Default or Event of Default exists on the date hereof; the execution, delivery and performance of this Amendment have been duly
authorized by all requisite corporate action on the part of Borrower and this Amendment has been duly executed and delivered by Borrower; and all of the representations and warranties made by Borrower in the Loan Agreement are true and correct on
and as of the date hereof. 

7.       
Reference to Loan Agreement. 	
Upon the effectiveness of this Amendment, each reference in the Loan Agreement to "this Agreement," "hereunder," or words of like import shall mean and be a reference to the Loan Agreement, 
as 
amended by this Amendment. 

8.       
Breach of Amendment. 	
This
Amendment shall be part of the Loan Agreement and a breach of any representation, warranty or covenant herein shall constitute an Event of Default.

9.       
Conditions Precedent. 	
The
effectiveness of the amendments contained in Section 
2 
hereof are subject to the satisfaction of each of the following
conditions precedent, in form and substance satisfactory to Lender, unless satisfaction thereof is specifically waived in writing by Lender:

(a)        Lender shall have received a duly
executed Secretary's Certificate of Board of Directors Resolutions authorizing
Borrower to enter into this Amendment; and

(b)        Lender shall have received a duly executed Landlord Waiver from L. Christopher Obenhaus with
respect to Borrower's location at 296 Grayson Highway, Lawrenceville, Georgia 30045. 	

10.       
Expenses of Lender. 
Borrower agrees to pay, 
on demand, 
all costs and expenses incurred by Lender in connection with the
preparation, negotiation and execution of this Amendment and any other Loan Documents executed pursuant hereto and any and all amendments, modifications, and supplements thereto, including, without limitation, the costs and fees of Lender's legal
counsel and any taxes or expenses associated with or incurred in connection with any instrument or agreement referred to herein or contemplated hereby.

11.       
Governing Law. 	
This
Amendment shall be governed by and construed in accordance with the internal laws of the State of Georgia.

12.       
Successors and Assigns. 	
This Amendment shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns.

13.       
No Novation, etc.. 
Except as
otherwise expressly provided in this Amendment, nothing herein shall be deemed to amend or modify any provision of the Loan Agreement or any of the other Loan Documents, each of which shall remain in full force and effect. This Amendment
is

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not intended to be, nor shall it be construed to create, a novation or accord and satisfaction, and the Loan Agreement as herein modified shall continue in full force and effect. 

14.        
Counterparts: Telecopied Signatures. This Amendment may be executed in any number of
counterparts and by different parties to this Amendment on separate counterparts, each of which, when so executed, shall be deemed an original, but all such counterparts shall constitute one and the same agreement. Any signature delivered by a party
by facsimile transmission shall be deemed to be an original signature hereto.

15.        	
Further Assurances. Borrower agrees to take such further actions as Lender shall reasonably request from time to time in connection herewith to evidence or give effect to the amendments set forth herein or
any of the transactions contemplated hereby. 

16.        
Section Titles. Section titles and references used in this Amendment shall be without
substantive meaning or content of any kind whatsoever and are not a part of the agreements among the parties hereto.

17.        	
Release of Claims. To induce Lender to enter into this Amendment, Borrower hereby releases,
acquits and forever discharges Lender, and all officers, directors, agents, employees, successors and assigns of Lender, from any and all liabilities, claims, demands, actions or causes of action of any kind or nature (if there be any), whether
absolute or contingent, disputed or undisputed, at law or in equity, or known or unknown, that Borrower now has or ever had against Lender arising under or in connection with any of the Loan Documents or otherwise. Borrower represents and warrants
to Lender that Borrower has not transferred or assigned to any Person any claim that Borrower ever had or claimed to have against Lender.

18.       	
Waiver of Jurv Trial. To the fullest extent permitted by applicable law, the parties hereto
each hereby waives the right to trial by jury in any action, suit, counterclaim or proceeding arising out of or related to this Amendment.

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IN WITNESS 
WHEREOF, the parties hereto have caused this 
Amendment to be duly executed under seal in and delivered by their respective duly authorized officers on the date first written above.

 

	
ATTEST:

 /s/ Mitchell Goodman

    Secretary
	NATIONAL VISION, INC. 
    

 
	("Borrower") 
 
	By:    /s/ Paul A.Criscillis, Jr.

    Title:  Sr. V.P. & CFO

	 	 
	
[CORPORATE SEAL]	 
	 	
FLEET CAPITAL CORPORATION 
    

("Lender ")

    By:  /s/ 

    Title:  SVP

 
[Consent 
and Reaffirmation on following page] 

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CONSENT AND REAFFIRMATION

Each of the undersigned guarantors of the Obligations of Borrower at any time owing to Lender hereby: (i) acknowledges receipt of a copy of the foregoing Fourth
Amendment to Loan and Security Agreement; (ii) consents to Borrower's execution and delivery thereof and of the other documents, instruments or agreements Borrower agrees to execute and deliver pursuant thereto; (iii) agrees to be bound thereby; and
(iv) affirms that nothing contained therein shall modify in any respect whatsoever its respective guaranty of the Obligations and reaffirms that such guaranty is and shall remain in full force and effect.

IN WITNESS WHEREOF, the undersigned have
executed this Consent and Reaffirmation, as of the date of such Fourth Amendment
to Loan and Security Agreement.

	 	
INTERNATIONAL VISION ASSOCIATES,

 By:  /s/ Mitchell
Goodman

      Title:  VP

	  	
 
	 	
NVAL HEALTHCARE SYSTEMS, INC.

 By:  /s/ Mitchell
Goodman

      Title:  VP

	 	
 
	 	
VISION ADMINISTRATORS, INC.

 By:  /s/ Mitchell
Goodman

      Title:  VP

 

[Signatures continued on next page]

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ALEXIS HOLDING COMPANY

 By:  /s/ Mitchell
Goodman

      Title:  VP

	 	
 
	 	
VISTA EYECARE NETWORK, LLC

 By:  /s/ Mitchell
Goodman

      Title:  VP

-8-

 

NATIONAL VISION, INC. 

SECRETARY'S CERTIFICATE 

OF 

BOARD OF DIRECTORS RESOLUTIONS

I, Mitchell Goodman, DO HEREBY CERTIFY,
that I am the Senior Vice President, General Counsel and Secretary of
NATIONAL VISION, INC. 
(the "Corporation"), a corporation duly organized and existing under and by virtue of the laws of the State of Georgia and am keeper of the
records and seal thereof; that the following is a true, correct and compared copy of the resolutions duly adopted by the unanimous consent of all members of the Board of Directors of said Corporation effective as of March
26,2004; and that said resolutions are still in full force and effect:

RESOLVED, that the Chairman of the Board, President, any Vice President, or any other officer or board member of this Corporation (or the designee of any of them),
each be, and each hereby is, authorized and empowered (either alone or in conjunction with any one or more of the other officers of the Corporation) to take, from time to time, all or any part of the following actions on or in behalf of the
Corporation: (i) to make, execute and deliver to 
FLEET CAPITAL CORPORATION 
("Lender") (1)

 a Fourth Amendment to Loan and Security Agreement (the "Amendment") providing for the amendment of certain terms of that certain Loan
and Security Agreement dated May 30,2001, between the Corporation and Lender (as at any time amended, the "Loan Agreement"), and (2) 
all other agreements, documents and instruments contemplated by or referred to in the Amendment or executed by the Corporation in connection therewith; said Amendment and other agreements, documents and instruments to be
substantially in the form presented by Lender with such additional, modified or revised terms as may be acceptable to any officer or director of the Corporation, as conclusively evidenced by his or her execution thereof; and (ii) to carry out,
modify, amend or terminate any arrangements or agreements at any time existing between the Corporation and Lender.

RESOLVED, that any arrangements,
agreements, security agreements, or other instruments or documents referred to
or executed pursuant to the Amendment by the Senior Vice President, Chief
Financial Officer, any other officer or director of the Corporation, or by an
employee of the Corporation acting pursuant to delegation of authority, may be
attested by such person and may contain such terms and provisions as such person
shall, in his or her sole discretion, determine.

RESOLVED, that the Loan Agreement and each
amendment to the Loan Agreement heretofore executed by any officer or director
of the Corporation and any actions taken under the Loan Agreement as thereby
amended are hereby ratified and approved.

 

 I DO FURTHER CERTIFY that Paul A. Criscillis, Jr. is the Senior Vice President and Chief Financial Officer
of the Corporation and is duly elected, qualified and acting as such. 

IN WITNESS WHEREOF, I have hereunto set my hand and affixed the Seal of the Corporation, this 1 st day of
April, 2004. 

	 	
/s/ Mitchell Goodman

Mitchell Goodman, 

Senior Vice President, General Counsel and

Secretary

	 	
[CORPORATE SEAL]

I, Paul A. Criscillis, Jr., Senior Vice President and Chief Financial Officer of said Corporation, do hereby certify that the foregoing is a correct copy of the
resolutions passed by the Board of Directors of the Corporation and that Mitchell Goodman is Senior Vice President, General Counsel and Secretary of the Corporation and is duly authorized to attest to the passage of said resolutions.

	 	
/s/ Paul A. Criscillis, Jr.

Paul A. Criscillis, Jr., 

Senior Vice President and Chief Financial

OfficerExhibit 4.3

                          SECURITIES PURCHASE AGREEMENT

      This Securities Purchase Agreement (this "Agreement") is dated as of May
11 2004, among Alfacell Corporation, a Delaware corporation (the "Company"), and
the purchasers identified on the signature pages hereto (each, a "Purchaser" and
collectively, the "Purchasers").

      WHEREAS, subject to the terms and conditions set forth in this Agreement
and pursuant to Section 4(2) of the Securities Act (as defined below) and Rule
506 promulgated thereunder, the Company desires to issue and sell to the
Purchasers, and the Purchasers, severally and not jointly, desire to purchase
from the Company certain securities of the Company, as more fully described in
this Agreement.

      NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this
Agreement, and for other good and valuable consideration the receipt and
adequacy of which are hereby acknowledged, the Company and the Purchasers agree
as follows:

                                    ARTICLE I.
                                   DEFINITIONS

      1.1 Definitions. In addition to the terms defined elsewhere in this
Agreement, for all purposes of this Agreement, the following terms shall have
the meanings indicated in this Section 1.1:

            "Action" means any action, suit, inquiry, notice of violation,
proceeding (including any partial proceeding such as a deposition) or
investigation pending or threatened in writing against or affecting the Company,
or its properties before or by any court, arbitrator, governmental or
administrative agency, regulatory authority (federal, state, county, local or
foreign), stock market, stock exchange or trading facility.

            "Affiliate" means any Person that, directly or indirectly through
one or more intermediaries, controls or is controlled by or is under common
control with a Person, as such terms are used in and construed under Rule 144.

            "Business Day" means any day except Saturday, Sunday and any day
which shall be a federal legal holiday or a day on which banking institutions in
the State of New York are authorized or required by law or other governmental
action to close.

            "Closing" means the closing of the purchase and sale of the
Securities pursuant to Section 2.

            "Closing Date" means the date of the Closing.

            "Commission" means the Securities and Exchange Commission.

<PAGE>

            "Common Stock" means the common stock of the Company, $.001 par
value per share, and any securities into which such common stock may hereafter
be reclassified.

            "Common Stock Equivalents" means any securities of the Company which
entitle the holder thereof to acquire Common Stock at any time, including
without limitation, any debt, preferred stock, rights, options, warrants or
other instrument that is at any time convertible into or exchangeable for, or
otherwise entitles the holder thereof to receive, Common Stock or other
securities that entitle the holder to receive, directly or indirectly, Common
Stock.

            "Company Counsel" means Dorsey & Whitney LLP.

            "Effective Date" means the date that a Registration Statement
required by the Registration Rights Agreement is first declared effective by the
Commission.

            "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

            "Investment Amount" means, with respect to each Purchaser, the
investment amount indicated below such Purchaser's name on the signature page of
this Agreement.

            "Lien" means any lien, charge, encumbrance, security interest, right
of first refusal or other restrictions of any kind.

            "Per Unit Purchase Price" equals $8.26.

            "Person" means an individual or corporation, partnership, trust,
incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof)
or other entity of any kind.

            "Placement Agent" means Emerging Growth Equities.

            "Proceeding" means an action, claim, suit, investigation or
proceeding (including, without limitation, an investigation or partial
proceeding, such as a deposition), whether commenced or threatened.

            "Purchaser Percentage" means, with respect to a Purchaser, the
percentage equal to the product of (x) a fraction, the numerator of which shall
be the Investment Amount paid by such Purchaser on the Closing Date and the
denominator of which shall be the aggregate Investment Amount paid by all
Purchasers on the Closing Date times (y) 100.

            "Registration Statement" means, collectively, one or more
registration statements meeting the requirements set forth in the Registration
Rights Agreement and covering the resale by the Purchasers of the applicable
Shares and the Warrant Shares.

                                      -2-
<PAGE>

            "Registration Rights Agreement" means the Registration Rights
Agreement, dated as of the date of this Agreement, among the Company and the
Purchasers, in the form of Exhibit A hereto.

            "Rule 144" means Rule 144 promulgated by the Commission pursuant to
the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

            "Securities" means the Shares, the Warrants and the Warrant Shares.

            "Securities Act" means the Securities Act of 1933, as amended.

            "Shares" means the shares of Common Stock issued or issuable to the
Purchasers pursuant to this Agreement.

            "Trading Day" means (i) a day on which the Common Stock is traded on
a Trading Market, or (ii) if the Common Stock is not listed on a Trading Market,
a day on which the Common Stock is traded in the over-the-counter market, as
reported by the OTC Bulletin Board, or (iii) if the Common Stock is not quoted
on the OTC Bulletin Board, a day on which the Common Stock is quoted in the
over-the-counter market as reported by the National Quotation Bureau
Incorporated (or any similar organization or agency succeeding to its functions
of reporting prices); provided, that in the event that the Common Stock is not
listed or quoted as set forth in (i), (ii) and (iii) hereof, then Trading Day
shall mean a Business Day.

            "Trading Market" means whichever of the New York Stock Exchange, the
American Stock Exchange, the NASDAQ National Market, the NASDAQ SmallCap Market
or OTC Bulletin Board on which the Common Stock is listed or quoted for trading
on the date in question.

            "Transaction Documents" means this Agreement, the Warrants, the
Registration Rights Agreement and any other documents or agreements executed in
connection with the transactions contemplated hereunder.

            "Warrants" means Common Stock Purchase Warrants in the form of
Exhibit B which are issuable to the Purchasers at Closing pursuant to Section
2.2(ii).

            "Warrant Shares" means the shares of Common Stock issuable upon
exercise of the Warrants, the number of which shall be calculated pursuant to
Section 2.2(ii).

                                   ARTICLE II.
                                PURCHASE AND SALE

      2.1 Closing. Subject to the terms and conditions set forth in this
Agreement, at the Closing the Company shall issue and sell to each Purchaser,
and each Purchaser shall, severally and not jointly, purchase from the Company,
the Shares and the Warrants representing such

                                      -3-
<PAGE>

Purchaser's Investment Amount. The Closing shall take place at the offices of
Dorsey & Whitney, 250 Park Avenue, New York, NY 10104 on the date this Agreement
is executed and delivered by the parties or at such other location or time as
the parties may agree.

      2.2 Closing Deliveries. (a) At the Closing, the Company shall deliver or
cause to be delivered to each Purchaser the following:

                  (i) a certificate evidencing a number of Shares equal to such
Purchaser's Investment Amount divided by the Per Unit Purchase Price, registered
in the name of such Purchaser;

                  (ii) a Warrant, registered in the name of such Purchaser,
pursuant to which such Purchaser shall have the right to acquire the number of
shares of Common Stock equal to 100% of the quotient obtained by dividing such
Purchaser's Investment Amount by the Per Unit Purchase Price;

                  (iii) the Registration Rights Agreement duly executed by the
Company.

            (b) At the Closing, each Purchaser shall deliver or cause to be
delivered to the Company the following:

                  (i) such Purchaser's Investment Amount, in United States
dollars and in immediately available funds, by wire transfer to an account
designated in writing by the Company for such purpose; and

                  (ii) the Registration Rights Agreement duly executed by such
Purchaser.

                                  ARTICLE III.
                         REPRESENTATIONS AND WARRANTIES

      3.1 Representations and Warranties of the Company. The Company hereby
makes the following representations and warranties to each Purchaser:

            (a) Subsidiaries. The Company has no direct or indirect
subsidiaries.

            (b) Organization and Qualification. The Company an entity duly
incorporated or otherwise organized, validly existing and in good standing under
the laws of the jurisdiction of its incorporation or organization (as
applicable), with the requisite power and authority to own and use its
properties and assets and to carry on its business as currently conducted. The
Company is not in violation of any of the provisions of its respective
certificate or articles of incorporation, bylaws or other organizational or
charter documents. The Company is duly qualified to conduct business and is in
good standing as a foreign corporation or other entity in each jurisdiction in
which the nature of the business conducted or property owned by it makes such
qualification necessary, except where the failure to be so qualified or in good
standing, as

                                      -4-
<PAGE>

the case may be, could not, individually or in the aggregate, have or reasonably
be expected to result in (i) an adverse effect on the legality, validity or
enforceability of any Transaction Document, (ii) a material and adverse effect
on the results of operations, assets, prospects, business or condition
(financial or otherwise) of the Company, taken as a whole, or (iii) an adverse
impairment to the Company's ability to perform on a timely basis its obligations
under any Transaction Document (any of (i), (ii) or (iii), a "Material Adverse
Effect").

            (c) Authorization; Enforcement. The Company has the requisite
corporate power and authority to enter into and to consummate the transactions
contemplated by each of the Transaction Documents and otherwise to carry out its
obligations thereunder. The execution and delivery of each of the Transaction
Documents by the Company and the consummation by it of the transactions
contemplated thereby have been duly authorized by all necessary action on the
part of the Company and no further action is required by the Company in
connection therewith. Each Transaction Document has been (or upon delivery will
have been) duly executed by the Company and, when delivered in accordance with
the terms hereof, will constitute the valid and binding obligation of the
Company enforceable against the Company in accordance with its terms.

            (d) No Conflicts. The execution, delivery and performance of the
Transaction Documents by the Company and the consummation by the Company of the
transactions contemplated thereby do not and will not (i) conflict with or
violate any provision of the Company's certificate or articles of incorporation,
bylaws or other organizational or charter documents, or (ii) conflict with, or
constitute a default (or an event that with notice or lapse of time or both
would become a default) under, or give to others any rights of termination,
amendment, acceleration or cancellation (with or without notice, lapse of time
or both) of, any agreement, credit facility, debt or other instrument or other
understanding to which the Company is a party or by which any property or asset
of the Company is bound or affected, or (iii) result in a violation of any law,
rule, regulation, order, judgment, injunction, decree or other restriction of
any court or governmental authority to which the Company is subject (including
federal and state securities laws and regulations), or by which any property or
asset of the Company is bound or affected; except in the case of each of clauses
(ii) and (iii), such as could not, individually or in the aggregate, have or
reasonably be expected to result in a Material Adverse Effect.

            (e) Filings, Consents and Approvals. The Company is not required to
obtain any consent, waiver, authorization or order of, give any notice to, or
make any filing or registration with, any court or other federal, state, local
or other governmental authority or other Person in connection with the
execution, delivery and performance by the Company of the Transaction Documents,
other than (i) the filing with the Commission of one or more Registration
Statements in accordance with the requirements Registration Rights Agreement,
(ii) the application(s) to the Trading Market on which the Common Stock is
listed for trading for the listing of the Shares and Warrant Shares for trading
thereon in the time and manner required thereby; and (iii) the filing with the
Commission of a Form D and the applicable blue sky forms in the relevant states.

                                      -5-
<PAGE>

            (f) Issuance of the Securities. The Securities have been duly
authorized and, when issued and paid for in accordance with the Transaction
Documents, will be duly and validly issued, fully paid and nonassessable, free
and clear of all Liens. The Company has reserved from its duly authorized
capital stock the maximum number of shares of Common Stock issuable pursuant to
this Agreement and the Warrants in order to issue the Shares and the full number
of Warrant Shares as are or may become issuable in accordance with the Warrants.

            (g) Capitalization. The number of shares and type of all authorized,
issued and outstanding capital stock of the Company, and all shares of Common
Stock reserved for issuance under the Company's various option and incentive
plans, is set forth in Schedule 3.1(a). Except as set forth in Schedule 3.1(a),
no securities of the Company are entitled to preemptive or similar rights, and
no Person has any right of first refusal, preemptive right, right of
participation, or any similar right to participate in the transactions
contemplated by the Transaction Documents. Except as a result of the purchase
and sale of the Securities and except as disclosed in Schedule 3.1(a), there are
no outstanding options, warrants, scrip rights to subscribe to, calls or
commitments of any character whatsoever relating to, or securities, rights or
obligations convertible into or exchangeable for, or giving any Person any right
to subscribe for or acquire, any shares of Common Stock, or contracts,
commitments, understandings or arrangements by which the Company is or may
become bound to issue additional shares of Common Stock, or securities or rights
convertible or exchangeable into shares of Common Stock. Except as set forth in
Schedule 3.1(a), the issue and sale of the Securities will not, immediately or
with the passage of time, obligate the Company to issue shares of Common Stock
or other securities to any Person (other than the Purchasers) and will not
result in a right of any holder of Company securities to adjust the exercise,
conversion, exchange or reset price under such securities.

            (h) SEC Reports; Financial Statements. The Company has informed the
Purchasers of the accessibility of all of its financial documents and any other
periodic report or definitive proxy statement required to be filed with the SEC
at www.sec.gov. The Company has filed all reports required to be filed by it
under the Securities Act and the Exchange Act, including pursuant to Section
13(a) or 15(d) thereof, for the twelve months preceding the date hereof (or such
shorter period as the Company was required by law to file such reports) (the
foregoing materials being collectively referred to herein as the "SEC Reports"
and, together with the Schedules to this Agreement, the "Disclosure Materials")
on a timely basis or has timely filed a valid extension of such time of filing
and has filed any such SEC Reports prior to the expiration of any such
extension. As of their respective dates, the SEC Reports complied in all
material respects with the requirements of the Securities Act and the Exchange
Act and the rules and regulations of the Commission promulgated thereunder, and
none of the SEC Reports, when filed, contained any untrue statement of a
material fact or omitted to state a material fact required to be stated therein
or necessary in order to make the statements therein, in light of the
circumstances under which they were made, not misleading. The financial
statements of the Company included in the SEC Reports comply in all material
respects with applicable accounting requirements and the rules and regulations
of the Commission with respect thereto as in effect at the time of filing. Such
financial statements have been prepared in accordance with

                                      -6-
<PAGE>

generally accepted accounting principles applied on a consistent basis during
the periods involved ("GAAP"), except as may be otherwise specified in such
financial statements or the notes thereto, and fairly present in all material
respects the financial position of the Company and its consolidated Subsidiaries
as of and for the dates thereof and the results of operations and cash flows for
the periods then ended, subject, in the case of unaudited statements, to normal,
immaterial, year-end audit adjustments. Notwithstanding anything to the contrary
in this Agreement, the Company's current financial performance may vary
materially from expectations disclosed in the Company's SEC Reports and other
publicly released information by the Company.

            (i) Material Changes. Since the date of the latest audited financial
statements included within the SEC Reports, except as specifically disclosed in
the SEC Reports, (i) there has been no event, occurrence or development that has
had or that could reasonably be expected to result in a Material Adverse Effect,
(ii) the Company has not incurred any liabilities (contingent or otherwise)
other than (A) trade payables and accrued expenses incurred in the ordinary
course of business consistent with past practice and (B) liabilities not
required to be reflected in the Company's financial statements pursuant to GAAP
or required to be disclosed in filings made with the Commission, (iii) the
Company has not altered its method of accounting or the identity of its
auditors, (iv) the Company has not declared or made any dividend or distribution
of cash or other property to its stockholders or purchased, redeemed or made any
agreements to purchase or redeem any shares of its capital stock, and (v) the
Company has not issued any equity securities to any officer, director or
Affiliate, except pursuant to existing Company stock option plans.

            (j) Litigation. There is no Action which (i) adversely affects or
challenges the legality, validity or enforceability of any of the Transaction
Documents or the Securities or (ii) could, if there were an unfavorable
decision, individually or in the aggregate, have or reasonably be expected to
result in a Material Adverse Effect. During the last three years, neither the
Company nor any director or officer thereof, is or has been the subject of any
Action involving a claim of violation of or liability under federal or state
securities laws or a claim of breach of fiduciary duty. Except as set forth in
the SEC Reports, there has not been, and to the knowledge of the Company, there
is not pending or contemplated, any investigation by the Commission involving
the Company or any current or former director or officer of the Company. The
Commission has not issued any stop order or other order suspending the
effectiveness of any registration statement filed by the Company under the
Exchange Act or the Securities Act.

            (k) Labor Relations. Except as disclosed in the SEC Reports, no
material labor dispute exists or, to the knowledge of the Company, is imminent
with respect to any of the employees of the Company.

            (l) Compliance. Except as disclosed in the SEC Reports, the Company
(i) is not in default under or in violation of (and no event has occurred that
has not been waived that, with notice or lapse of time or both, would result in
a default by the Company), nor has the Company received notice of a claim that
it is in default under or that it is in violation of, any

                                      -7-
<PAGE>

indenture, loan or credit agreement or any other agreement or instrument to
which it is a party or by which it or any of its properties is bound (whether or
not such default or violation has been waived), (ii) is in violation of any
order of any court, arbitrator or governmental body, or (iii) is or has been in
violation of any statute, rule or regulation of any governmental authority,
including without limitation all foreign, federal, state and local laws relating
to taxes, environmental protection, occupational health and safety, product
quality and safety and employment and labor matters, except in each case as
could not, individually or in the aggregate, have or reasonably be expected to
result in a Material Adverse Effect. The Company is in compliance with the
applicable requirements of the Sarbanes-Oxley Act of 2002 and the rules and
regulations thereunder promulgated by the Commission, except where such
noncompliance could not have or reasonably be expected to result in a Material
Adverse Effect. The Company and the manufacture, marketing and sales of its
products comply with any and all applicable requirements of the Federal Food,
Drug and Cosmetic Act, 21 U.S.C. ss. 301, et seq., any applicable rules and
regulations of the Food and Drug Administration promulgated thereunder, and any
similar laws outside of the United States to which the Company is subject,
except where such noncompliance could not have or reasonably be expected to
result in a Material Adverse Effect.

            (m) Regulatory Permits. The Company possesses all certificates,
authorizations and permits issued by the appropriate federal, state, local or
foreign regulatory authorities necessary to conduct its business as described in
the SEC Reports, except where the failure to possess such permits would not,
individually or in the aggregate, have or reasonably be expected to result in a
Material Adverse Effect ("Material Permits"), and the Company has not received
any notice of proceedings relating to the revocation or modification of any
Material Permit.

            (n) Title to Assets. The Company has good and marketable title in
fee simple to all real property owned by it that is material to its business and
good and marketable title in all personal property owned by it that is material
to its business, in each case free and clear of all Liens, except for Liens
disclosed in the SEC Reports and Liens as do not materially affect the value of
such property and do not materially interfere with the use made and proposed to
be made of such property by the Company. Except as disclosed on Schedule 3.1(n)
or in the SEC Reports, all real property and facilities held under lease by the
Company are held under valid, subsisting and enforceable leases of which the
Company is in substantial compliance.

            (o) Patents and Trademarks. To the knowledge of the Company, the
Company owns, or have rights to use, all patents, patent applications,
trademarks, trademark applications, service marks, trade names, copyrights and
other similar rights (collectively, the "Intellectual Property Rights") that are
necessary for conducting its business as described in the SEC Reports and which
the failure to so have could, individually or in the aggregate, have or
reasonably be expected to result in a Material Adverse Effect. The Company has
not received a written notice that the Intellectual Property Rights used by the
Company violates or infringes upon the rights of any Person. Except as set forth
in the SEC Reports, to the knowledge of the

                                      -8-
<PAGE>

Company, all such Intellectual Property Rights are enforceable and there is no
existing infringement by another Person of any of the Intellectual Property
Rights.

            (p) Insurance. The Company is insured by insurers of recognized
financial responsibility against such losses and risks and in such amounts as
are prudent and customary in the businesses in which the Company is engaged. The
Company has no reason to believe that it will not be able to renew its existing
insurance coverage as and when such coverage expires or to obtain similar
coverage from similar insurers as may be necessary to continue its business
without a significant increase in cost.

            (q) Transactions With Affiliates and Employees. Except as set forth
in the SEC Reports, none of the officers or directors of the Company and, to the
knowledge of the Company, none of the employees of the Company is presently a
party to any transaction with the Company (other than for services as employees,
officers and directors), including any contract, agreement or other arrangement
providing for the furnishing of services to or by, providing for rental of real
or personal property to or from, or otherwise requiring payments to or from any
officer, director or such employee or, to the knowledge of the Company, any
entity in which any officer, director, or any such employee has a substantial
interest or is an officer, director, trustee or partner.

            (r) Internal Accounting Controls. The Company maintains a system of
internal accounting controls sufficient to provide reasonable assurance that (i)
transactions are executed in accordance with management's general or specific
authorizations, (ii) transactions are recorded as necessary to permit
preparation of financial statements in conformity with generally accepted
accounting principles and to maintain asset accountability, (iii) access to
assets is permitted only in accordance with management's general or specific
authorization, and (iv) the recorded accountability for assets is compared with
the existing assets at reasonable intervals and appropriate action is taken with
respect to any differences.

            (s) Certain Fees. In consideration for services rendered by the
Placement Agent in placing the Shares, the Company has agreed to pay the
Placement Agent on the Closing Date, (i) a cash payment equal to five percent
(5%) of the gross proceeds of the sale of the Shares sold pursuant to Section
2.2(i) of this Securities Purchase Agreement, ; and (ii) issue to the Placement
Agent a warrant to purchase a number of shares of Common Stock equal to five
percent (5%) of the aggregate Warrant Shares, with an exercise price of $12.39
under the same terms and conditions as the Warrants. Other than as set forth
herein, the Company has no obligation to pay brokers' fees or commissions by
virtue of the sale of the Shares. The Purchasers shall have no obligation with
respect to any fees or with respect to any claims (other than such fees or
commissions owed by a Purchaser pursuant to written agreements executed by such
Purchaser which fees or commissions shall be the sole responsibility of such
Purchaser) made by or on behalf of other Persons for fees of a type contemplated
in this Section that may be due in connection with the transactions contemplated
by this Agreement.

                                      -9-
<PAGE>

            (t) Certain Registration Matters. Assuming the accuracy of the
Purchasers' representations and warranties set forth in Section 3.2(b)-(e), no
registration under the Securities Act is required for the offer and sale of the
Shares and Warrant Shares by the Company to the Purchasers under the Transaction
Documents. The Company is eligible to register the resale of its Common Stock
for resale by the Purchasers under Form S-1 promulgated under the Securities
Act.

            (u) Listing and Maintenance Requirements. Except as specified in the
SEC Reports, the Company has not, in the two years preceding the date hereof,
received notice (written or oral) from any Trading Market to the effect that the
Company is not in compliance with the listing or maintenance requirements
thereof. The Company is, and has no reason to believe that it will not in the
foreseeable future continue to be, in compliance with the listing and
maintenance requirements for continued listing of the Common Stock on the OTC
Bulletin Board. The issuance and sale of the Securities under the Transaction
Documents does not contravene the rules and regulations of the Trading Market on
which the Common Stock is currently listed or quoted or any other Trading Market
with whom the Company may be in formal discussions regarding the listing of the
Common Stock, and no approval of the shareholders of the Company thereunder is
required for the Company to issue and deliver to the Purchasers the maximum
number of Securities contemplated by Transaction Documents.

            (v) Investment Company. The Company is not, and is not an Affiliate
of, an "investment company" within the meaning of the Investment Company Act of
1940, as amended.

            (w) No Additional Agreements. The Company does not have any
agreement or understanding with any Purchaser with respect to the transactions
contemplated by the Transaction Documents other than as specified in the
Transaction Documents.

            (x) Disclosure. The Company confirms that neither it nor any Person
acting on its behalf has provided any of the Purchasers or their agents or
counsel with any information that the Company believes constitutes material,
non-public information. The Company understands and confirms that the Purchasers
will rely on the foregoing representations and covenants in effecting
transactions in securities of the Company. All disclosure provided to the
Purchasers regarding the Company, its business and the transactions contemplated
hereby, furnished by or on behalf of the Company (including the Company's
representations and warranties set forth in this Agreement) are true and correct
and do not contain any untrue statement of a material fact or omit to state any
material fact necessary in order to make the statements made therein, in light
of the circumstances under which they were made, not misleading.

      3.2 Representations and Warranties of the Purchasers. Each Purchaser
hereby, for itself and for no other Purchaser, represents and warrants to the
Company as follows:

            (a) Organization; Authority. Such Purchaser is an entity duly
organized, validly existing and in good standing under the laws of the
jurisdiction of its organization with

                                      -10-
<PAGE>

the requisite corporate or partnership power and authority to enter into and to
consummate the transactions contemplated by the applicable Transaction Documents
and otherwise to carry out its obligations thereunder. The execution, delivery
and performance by such Purchaser of the transactions contemplated by this
Agreement has been duly authorized by all necessary corporate or, if such
Purchaser is not a corporation, such partnership, limited liability company or
other applicable like action, on the part of such Purchaser. Each of this
Agreement and the Registration Rights Agreement has been duly executed by such
Purchaser, and when delivered by such Purchaser in accordance with terms hereof,
will constitute the valid and legally binding obligation of such Purchaser,
enforceable against it in accordance with its terms.

            (b) Investment Intent. Such Purchaser is acquiring the Securities as
principal for its own account for investment purposes only and not with a view
to or for distributing or reselling such Securities or any part thereof, without
prejudice, however, to such Purchaser's right at all times to sell or otherwise
dispose of all or any part of such Securities in compliance with applicable
federal and state securities laws. Subject to the immediately preceding
sentence, nothing contained herein shall be deemed a representation or warranty
by such Purchaser to hold the Securities for any period of time. Such Purchaser
is acquiring the Securities hereunder in the ordinary course of its business.
Such Purchaser does not have any agreement or understanding, directly or
indirectly, with any Person to distribute any of the Securities.

            (c) Purchaser Status. At the time such Purchaser was offered the
Securities, it was, and at the date hereof and as of the Closing Date it is, and
on each date on which it exercises the Warrants it will be, an "accredited
investor" as defined in Rule 501(a) under the Securities Act. Such Purchaser is
not a registered broker-dealer under Section 15 of the Exchange Act.

            (d) General Solicitation. Such Purchaser is not purchasing the
Securities as a result of any advertisement, article, notice or other
communication regarding the Securities published in any newspaper, magazine or
similar media or broadcast over television or radio or presented at any seminar
or any other general solicitation or general advertisement.

            (e) Access to Information. Such Purchaser acknowledges that it has
reviewed the Disclosure Materials and has been afforded (i) the opportunity to
ask such questions as it has deemed necessary of, and to receive answers from,
representatives of the Company concerning the terms and conditions of the
offering of the Shares and the merits and risks of investing in the Securities;
(ii) access to information about the Company and its respective financial
condition, results of operations, business, properties, management and prospects
sufficient to enable it to evaluate its investment; and (iii) the opportunity to
obtain such additional information that the Company possesses or can acquire
without unreasonable effort or expense that is necessary to make an informed
investment decision with respect to the investment. Neither such inquiries nor
any other investigation conducted by or on behalf of such Purchaser or its
representatives or counsel shall modify, amend or affect such Purchaser's right
to rely on the truth, accuracy and completeness of the Disclosure Materials and
the Company's representations and warranties contained in the Transaction
Documents.

                                      -11-
<PAGE>

            (f) Disclosure. Such Purchaser understands and confirms that the
Company will rely on the foregoing representations and covenants of such
Purchaser in evaluating whether or not registration is required under the
Securities Act for the offer, sale and issuance of the Securities to such
Purchaser as contemplated herein.

The Company acknowledges and agrees that each Purchaser does not make or has not
made any representations or warranties with respect to the transactions
contemplated hereby other than those specifically set forth in this Section 3.2.

                                  ARTICLE IV.
                         OTHER AGREEMENTS OF THE PARTIES

      4.1   (a) Securities may only be disposed of in compliance with state and
federal securities laws. In connection with any transfer of the Securities other
than pursuant to an effective registration statement, to the Company, to an
Affiliate of a Purchaser or in connection with a pledge as contemplated in
Section 4.1(b), the Company may require the transferor thereof to provide to the
Company an opinion of counsel selected by the transferor, the form and substance
of which opinion shall be reasonably satisfactory to the Company, to the effect
that such transfer does not require registration of such transferred Securities
under the Securities Act.

            (b) Certificates evidencing the Securities will contain the
following legend, so long as is required by this Section 4.1(b), with
appropriate inclusion or exclusion of bracketed text depending on whether the
legend is to be applied to a stock certificate or a Warrant:

            [NEITHER THESE SECURITIES NOR THE SECURITIES ISSUABLE UPON EXERCISE
            OF THESE SECURITIES HAVE BEEN REGISTERED] [THESE SECURITIES HAVE NOT
            BEEN REGISTERED]WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE
            SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION
            FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
            "SECURITIES ACT"), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD
            EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE
            SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A
            TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE
            SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES
            LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO
            SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE
            TO THE COMPANY. [THESE SECURITIES AND THE SECURITIES ISSUABLE UPON
            EXERCISE OF THESE SECURITIES] [THESE SECURITIES] MAY BE PLEDGED IN
            CONNECTION WITH A BONA FIDE MARGIN ACCOUNT SECURED BY SUCH
            SECURITIES.

                                      -12-
<PAGE>

      4.2 Securities Laws Disclosure; Publicity. On the Closing Date, the
Company shall issue a press release reasonably acceptable to the Purchasers
disclosing the transactions contemplated hereby and file a Current Report on
Form 8-K disclosing the material terms of the transactions contemplated hereby.
In addition, the Company will make such other filings and notices in the manner
and time required by the Commission and the Trading Market on which the Common
Stock is listed. Notwithstanding the foregoing, the Company shall not publicly
disclose the name of any Purchaser, or include the name of any Purchaser in any
filing with the Commission (other than the Registration Statement and any
exhibits to filings made in respect of this transaction in accordance with
periodic filing requirements under the Exchange Act) or any regulatory agency or
Trading Market, without the prior written consent of such Purchaser, which shall
not be unreasonably withheld or delayed, except to the extent such disclosure is
required by law or Trading Market regulations, in which case the Company shall
provide the Purchasers with prior notice of such disclosure.

      4.3 Non-Public Information. The Company covenants and agrees that neither
it nor any other Person acting on its behalf will provide any Purchaser or its
agents or counsel with any information that the Company believes constitutes
material non-public information, unless prior thereto such Purchaser shall have
executed a written agreement regarding the confidentiality and use of such
information. The Company understands and confirms that each Purchaser shall be
relying on the foregoing representations in effecting transactions in securities
of the Company.

                                   ARTICLE V.
                                  MISCELLANEOUS

      5.1 Fees and Expenses. Each party will bear its own costs and expenses in
connection with this Agreement.

      5.2 Entire Agreement. The Transaction Documents, together with the
Exhibits and Schedules thereto, contain the entire understanding of the parties
with respect to the subject matter hereof and supersede all prior agreements and
understandings, oral or written, with respect to such matters, which the parties
acknowledge have been merged into such documents, exhibits and schedules.

      5.3 Notices. Any and all notices or other communications or deliveries
required or permitted to be provided hereunder shall be in writing and shall be
deemed given and effective on the earliest of (a) the date of transmission, if
such notice or communication is delivered via facsimile at the facsimile number
specified in this Section prior to 6:30 p.m. (New York City time) on a Trading
Day, (b) the next Trading Day after the date of transmission, if such notice or
communication is delivered via facsimile at the facsimile number specified in
this Section on a day that is not a Trading Day or later than 6:30 p.m. (New
York City time) on any Trading Day, (c) the Trading Day following the date of
mailing, if sent by U.S. nationally recognized overnight courier service, or (d)
upon actual receipt by the party to whom such notice is required to be given.
The address for such notices and communications shall be as follows:

                                      -13-
<PAGE>

      If to the Company:   Alfacell Corporation
                           225 Belleville Avenue,
                           Bloomfield, NJ 07003
                           Attn: Chief Executive Officer
                           Facsimile No.: (973) 748-1355

      With a copy to:      Dorsey & Whitney LLP
                           250 Park Avenue
                           New York, NY 10177
                           Attn: Kevin T. Collins
                           Facsimile No.: (212) 953-7201

      If to a Purchaser:   To the address set forth under such Purchaser's name
                           on the signature pages hereof;

or such other address as may be designated in writing hereafter, in the same
manner, by such Person.

      5.4 Amendments; Waivers. No provision of this Agreement may be waived or
amended except in a written instrument signed, in the case of an amendment, by
the Company and each of the Purchasers or, in the case of a waiver, by the party
against whom enforcement of any such waiver is sought. No waiver of any default
with respect to any provision, condition or requirement of this Agreement shall
be deemed to be a continuing waiver in the future or a waiver of any subsequent
default or a waiver of any other provision, condition or requirement hereof, nor
shall any delay or omission of either party to exercise any right hereunder in
any manner impair the exercise of any such right.

      5.5 Construction. The headings herein are for convenience only, do not
constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof. The language used in this Agreement will be deemed
to be the language chosen by the parties to express their mutual intent, and no
rules of strict construction will be applied against any party. This Agreement
shall be construed as if drafted jointly by the parties, and no presumption or
burden of proof shall arise favoring or disfavoring any party by virtue of the
authorship of any provisions of this Agreement or any of the Transaction
Documents.

      5.6 Successors and Assigns. This Agreement shall be binding upon and inure
to the benefit of the parties and their successors and permitted assigns. The
Company may not assign this Agreement or any rights or obligations hereunder
without the prior written consent of the Purchasers. Any Purchaser may assign
any or all of its rights under this Agreement to any Person to whom such
Purchaser assigns or transfers any Securities, provided such transferee agrees
in writing to be bound, with respect to the transferred Securities, by the
provisions hereof that apply to the "Purchasers."

                                      -14-
<PAGE>

      5.7 No Third-Party Beneficiaries. This Agreement is intended for the
benefit of the parties hereto and their respective successors and permitted
assigns and is not for the benefit of, nor may any provision hereof be enforced
by, any other Person, except as otherwise set forth in Section 4.6.

      5.8 Governing Law. All questions concerning the construction, validity,
enforcement and interpretation of this Agreement shall be governed by and
construed and enforced in accordance with the internal laws of the State of New
York, without regard to the principles of conflicts of law thereof. Each party
agrees that all Proceedings concerning the interpretations, enforcement and
defense of the transactions contemplated by this Agreement and any other
Transaction Documents (whether brought against a party hereto or its respective
Affiliates, employees or agents) shall be commenced exclusively in the state and
federal courts sitting in the City of New York, Borough of Manhattan (the "New
York Courts"). Each party hereto hereby irrevocably submits to the exclusive
jurisdiction of the New York Courts for the adjudication of any dispute
hereunder or in connection herewith or with any transaction contemplated hereby
or discussed herein (including with respect to the enforcement of the any of the
Transaction Documents), and hereby irrevocably waives, and agrees not to assert
in any Proceeding, any claim that it is not personally subject to the
jurisdiction of any such New York Court, or that such Proceeding has been
commenced in an improper or inconvenient forum. Each party hereto hereby
irrevocably waives personal service of process and consents to process being
served in any such Proceeding by mailing a copy thereof via registered or
certified mail or overnight delivery (with evidence of delivery) to such party
at the address in effect for notices to it under this Agreement and agrees that
such service shall constitute good and sufficient service of process and notice
thereof. Nothing contained herein shall be deemed to limit in any way any right
to serve process in any manner permitted by law. Each party hereto hereby
irrevocably waives, to the fullest extent permitted by applicable law, any and
all right to trial by jury in any legal proceeding arising out of or relating to
this Agreement or the transactions contemplated hereby. If either party shall
commence a Proceeding to enforce any provisions of a Transaction Document, then
the prevailing party in such Proceeding shall be reimbursed by the other party
for its attorney's fees and other costs and expenses incurred with the
investigation, preparation and prosecution of such Proceeding.

      5.9 Survival. The representations, warranties, agreements and covenants
contained herein shall survive the Closing Date and the delivery of the
applicable Securities.

      5.10 Execution. This Agreement may be executed in two or more
counterparts, all of which when taken together shall be considered one and the
same agreement and shall become effective when counterparts have been signed by
each party and delivered to the other party, it being understood that both
parties need not sign the same counterpart. In the event that any signature is
delivered by facsimile transmission, such signature shall create a valid and
binding obligation of the party executing (or on whose behalf such signature is
executed) with the same force and effect as if such facsimile signature page
were an original thereof.

                                      -15-
<PAGE>

      5.11 Severability. If any provision of this Agreement is held to be
invalid or unenforceable in any respect, the validity and enforceability of the
remaining terms and provisions of this Agreement shall not in any way be
affected or impaired thereby and the parties will attempt to agree upon a valid
and enforceable provision that is a reasonable substitute therefor, and upon so
agreeing, shall incorporate such substitute provision in this Agreement.

      5.12 Rescission and Withdrawal Right. Notwithstanding anything to the
contrary contained in (and without limiting any similar provisions of) the
Transaction Documents, whenever any Purchaser exercises a right, election,
demand or option under a Transaction Document and the Company does not timely
perform its related obligations within the periods therein provided, then such
Purchaser may rescind or withdraw, in its sole discretion from time to time upon
written notice to the Company, any relevant notice, demand or election in whole
or in part without prejudice to its future actions and rights.

      5.13 Replacement of Securities. If any certificate or instrument
evidencing any Securities is mutilated, lost, stolen or destroyed, the Company
shall issue or cause to be issued in exchange and substitution for and upon
cancellation thereof, or in lieu of and substitution therefor, a new certificate
or instrument, but only upon receipt of evidence reasonably satisfactory to the
Company of such loss, theft or destruction and customary and reasonable
indemnity, if requested. The applicants for a new certificate or instrument
under such circumstances shall also pay any reasonable third-party costs
associated with the issuance of such replacement Securities. If a replacement
certificate or instrument evidencing any Securities is requested due to a
mutilation thereof, the Company may require delivery of such mutilated
certificate or instrument as a condition precedent to any issuance of a
replacement.

      5.14 Remedies. In addition to being entitled to exercise all rights
provided herein or granted by law, including recovery of damages, each of the
Purchasers and the Company will be entitled to specific performance under the
Transaction Documents. The parties agree that monetary damages may not be
adequate compensation for any loss incurred by reason of any breach of
obligations described in the foregoing sentence and hereby agrees to waive in
any action for specific performance of any such obligation the defense that a
remedy at law would be adequate.

      5.15 Payment Set Aside. To the extent that the Company makes a payment or
payments to any Purchaser pursuant to any Transaction Document or a Purchaser
enforces or exercises its rights thereunder, and such payment or payments or the
proceeds of such enforcement or exercise or any part thereof are subsequently
invalidated, declared to be fraudulent or preferential, set aside, recovered
from, disgorged by or are required to be refunded, repaid or otherwise restored
to the Company, a trustee, receiver or any other person under any law
(including, without limitation, any bankruptcy law, state or federal law, common
law or equitable cause of action), then to the extent of any such restoration
the obligation or part thereof originally intended to be satisfied shall be
revived and continued in full force and effect as if such payment had not been
made or such enforcement or setoff had not occurred.

                                      -16-
<PAGE>

      5.16 Independent Nature of Purchasers' Obligations and Rights. The
obligations of each Purchaser under any Transaction Document are several and not
joint with the obligations of any other Purchaser, and no Purchaser shall be
responsible in any way for the performance of the obligations of any other
Purchaser under any Transaction Document. Nothing contained herein or in any
Transaction Document, and no action taken by any Purchaser pursuant thereto,
shall be deemed to constitute the Purchasers as a partnership, an association, a
joint venture or any other kind of entity, or create a presumption that the
Purchasers are in any way acting in concert or as a group with respect to such
obligations or the transactions contemplated by the Transaction Document. Each
Purchaser shall be entitled to independently protect and enforce its rights,
including without limitation the rights arising out of this Agreement or out of
the other Transaction Documents, and it shall not be necessary for any other
Purchaser to be joined as an additional party in any proceeding for such
purpose.

                   [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK
                             SIGNATURE PAGES FOLLOW]

                                      -17-
<PAGE>

      IN WITNESS WHEREOF, the parties hereto have caused this Securities
Purchase Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.

                                            ALFACELL CORPORATION

                                            ------------------------------------
                                            Name:  Kuslima Shogen
                                            Title: Chief Executive Officer

                                            PURCHASER

                                            KNOLL CAPITAL FUND II

                                            By:
                                               ---------------------------------
                                            Name:
                                            Title:

                                            Address for Notice:
                                                   200 Park Avenue, Suite 3900
                                                   New York, NY 10166
                                                   Attn: Fred Knoll

                                            With a copy to:

Investment Amount: $4,894,050

Per Unit Purchase Price: $8.26

Number of Shares being Purchased: 592,500

Number of Warrant Shares purchasable under Warrant: 592,500

Exercise Price of Warrant: $12.39

                                      -18-
<PAGE>

      IN WITNESS WHEREOF, the parties hereto have caused this Securities
Purchase Agreement to be duly executed by their respective authorized
signatories as of the date first indicated above.

                                            ALFACELL CORPORATION

                                            ------------------------------------
                                            Name:  Kuslima Shogen
                                            Title: Chief Executive Officer

                                            PURCHASER

                                            EUROPA INTERNATIONAL, INC.

                                            By:
                                               ---------------------------------
                                            Name:
                                            Title:

                                            Address for Notice:
                                                   200 Park Avenue, Suite 3900
                                                   New York, NY 10166
                                                   Attn: Fred Knoll

                                            With a copy to:

Investment Amount: $4,894,050

Per Unit Purchase Price: $8.26

Number of Shares being Purchased: 592,500

Number of Warrant Shares purchasable under Warrant: 592,500

Exercise Price of Warrant: $12.39

                                      -19-

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