Document:

<PAGE>

WHEREVER CONFIDENTIAL INFORMATION IS OMITTED HEREIN (SUCH OMISSIONS ARE DENOTED
BY AN ASTERISK), SUCH CONFIDENTIAL INFORMATION HAS BEEN SUBMITTED SEPARATELY TO
THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO A REQUEST FOR CONFIDENTIAL
TREATMENT

EXHIBIT 10.1

                            PATENT PURCHASE AGREEMENT

     AGREEMENT dated as of May 9, 2000 between Repligen Corporation, a Delaware
company with offices at 117 Fourth Ave., Needham, MA 02494 ("BUYER"), and
Tolerance Therapeutics LLC, an Illinois limited liability company with offices
at Suite 3N, 5490 South Shore Drive, Chicago, IL 60615 ("SELLER").

     NOW, THEREFORE, in consideration of the representations, warranties,
covenants and agreements herein contained, the parties hereto agree as follows:

                                    ARTICLE I

                                   DEFINITIONS

     1.01. DEFINITIONS. The following terms, as used herein, have the following
meanings:

     "AFFILIATE" means, with respect to any Person, any Person directly or
indirectly controlling, controlled by, or under common control with such other
Person.

     "ASSET REVERSION" means the reversion of all rights associated with the
Purchased Asset from the Buyer back to the Seller pursuant to the terms and
conditions of Section 2.02(c) of this Agreement

     "BLUESTONE" means Dr. Jeffrey Bluestone, a named inventor on the Patent
Application.

     "CONVEYANCE DOCUMENTS" means (i) assignments of the Patent Applications in
the Form attached hereto on EXHIBIT A and (ii) a Bill of Sale, in the form
attached hereto as EXHIBIT B, conveying the Intellectual Property Rights from
Seller to Buyer.

     "CLOSING" means the transaction in which the title to the Purchased Assets
is transferred from Seller to Buyer and the Purchase Price is paid by Buyer to
Seller.

     "CLOSING DATE" means the date of the Closing.

     "GOVERNMENTAL AUTHORITY" means any government, court, regulatory or
administrative agency or commission, or other governmental authority, agency or
instrumentality, whether federal, state or local (domestic or foreign),
including, without limitation, the U.S. Patent and Trademark Office (the "PTO")
and the U.S. National Institutes of Health.

     "LIEN" means any mortgage, lien, pledge, charge, security interest or
encumbrance of any kind.

     "INTELLECTUAL PROPERTY RIGHTS" means any and all rights owned by Seller
outside of a Patent or Patent Application which may be required by Buyer to
commercialize the rights claimed by a Patent or Patent Application.

     "PATENT OR PATENT APPLICATION" means U.S. Patent Application USSN
08/696,107, filed August 13, 1996, and any and all patent applications or
continuation, continuation-in-part, or divisional applications which claim
priority thereto, and any patents issuing from any of the foregoing, and any
extensions, reissues, re-examinations, renewals, substitutions related to any of
the foregoing (including without limitation remedies against infringements
thereof and rights of protection of an interest therein under the laws of all
jurisdictions) and any and all foreign counterparts of any of the foregoing, and
all documentation, notes or other materials of Seller with respect to the
foregoing (the "PATENT DOCUMENTATION")

     "PERSON" means an individual, corporation, partnership, association, trust
or other entity or organization, including a government or political subdivision
or an agency or instrumentality thereof.

<PAGE>

     "PURCHASED ASSETS" means a Patent or Patent Application and any
Intellectual Property Rights.

     "SHARES" shall mean those shares of common stock of the Company issued by
Buyer to Seller pursuant to the term and conditions of this Agreement.

     "VALID CLAIM" means a claim included in a Patent or Patent Application
which is actively being prosecuted or which is included in an unexpired United
States or foreign patent which issues from the Patent Application and which
shall not have been withdrawn, canceled or disclaimed, nor held invalid by a
court of competent jurisdiction in an unappealed or unappealable decision.

                                   ARTICLE II

                                PURCHASE AND SALE

     2.01. PURCHASE AND SALE. Upon the terms and subject to the conditions of
this Agreement, Buyer agrees to purchase from Seller, and Seller agrees to sell,
transfer, assign and deliver, or cause to be sold, transferred, assigned and
delivered, to Buyer at Closing, free and clear of all Liens, all right, title
and interest in and throughout the United States of America, its territories and
all foreign countries, in and to the Purchased Assets.

     2.02. PURCHASE PRICE. The purchase price (the "PURCHASE PRICE") for the
Purchased Assets is as set forth below and shall be paid as follows:

     (a)  Buyer shall deliver to Seller at the Closing * by check or wire
          transfer;

     (b)  Buyer shall cause to be issued to Seller as soon as reasonably
practicable after the Closing Date, Thirty Thousand (30,000) shares (as adjusted
for any stock-splits, stock dividends and the like (after the date hereof up to
the date of issuance) of common stock of Buyer; and

     (c)  Subject to the terms herein, on or before the Contingent Payment Due
Date (as defined herein), Buyer shall, in its sole discretion, either (i)
deliver to Seller * by check or wire transfer (the "CONTINGENT PAYMENT") or (ii)
convey all right, title and interest in and to the Purchased Assets to Seller in
accordance with Section 6.02 hereunder. For purposes of this Agreement, the
"CONTINGENT PAYMENT DUE DATE," shall mean the earlier of (i) declaration of
interference by the Board of Appeals and Interferences of the U.S. Patent and
Trademark Office which results indirectly or directly in Craig Thompson being
named as an inventor on the Patent or Patent Application, (ii) the issuance of a
U.S. patent covered by the Patent Application, (iii) the abandonment of the
Patent Application, (iv) the settlement of matters relating to CTLA-4 between
Buyer and Bristol Meyers Squibb and/or its Affiliates relating to the Patent
Application or any patent issued from it, or (v) May 9, 2001.

     2.03. CLOSING. The closing (the "CLOSING") of the purchase and sale of the
Purchased Assets hereunder shall take place at the offices of Testa, Hurwitz &
Thibeault, LLP, 125 High Street, Boston, MA 02110 on May 9, 2000 at 10:00 a.m.,
eastern time, or at such other time or place as Buyer and Seller may agree. At
the Closing,

     (a)  Buyer shall pay the Purchase Price to Seller in accordance with the
terms of Sections 2.02(a) and 2.02(b) herein.

     (b)  Buyer and Seller shall execute and deliver the Conveyance Documents to
which each is a party.

     (c)  Buyer and Seller shall also execute and deliver all such other
instruments, documents and certificates as may be reasonably requested by the
other party that are necessary for the consummation at the Closing of the
transactions contemplated by this Agreement.

* CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                   ARTICLE III

                    REPRESENTATIONS AND WARRANTIES OF SELLER

     Except as otherwise provided herein, the Seller hereby represents and
warrants to Buyer that:

     3.01. CORPORATE EXISTENCE AND POWER OF SELLER. Seller represents and
warrants to Buyer that it is a limited liability company, duly organized,
validly existing and in good standing under the laws of the State of Illinois,
and has all requisite powers and all licenses, authorizations, consents and
approvals required to carry on its business as now conducted.

     3.02. CORPORATE AND APPROPRIATE AUTHORIZATION. Seller represents and
warrants to Buyer that the execution, delivery and performance by Seller of this
Agreement and the Conveyance Documents, and the consummation by Seller of the
transactions contemplated hereby and thereby, are within Seller's legal powers
and have been duly authorized by all necessary action on the part of Seller.
Seller represents and warrants to Buyer that this Agreement and the Conveyance
Documents have been duly executed and delivered and constitute valid and binding
agreements of Seller.

     3.03. GOVERNMENTAL AUTHORIZATION. To the best of Seller's knowledge, the
execution, delivery and performance by Seller of this Agreement and each of the
Conveyance Documents do not require any notice to, action or consent by or in
respect of, or filing with, any Governmental Authority (other than the filing of
patent assignments with the PTO and any other applicable Governmental
Authority).

     3.04. NON-CONTRAVENTION OF SELLER. Seller represents and warrants to Buyer
that the execution, delivery and performance by Seller of this Agreement and
each of the Conveyance Documents does not and will not (i) contravene or
conflict with the operating agreement or bylaws of Seller; (ii) contravene or
conflict with or constitute a violation of any provision of any law or
regulation binding upon or applicable to Seller or the Purchased Assets which
contravention, conflict or violation would have a material adverse effect on the
Purchased Assets or their intended use; (iii) contravene or conflict with or
constitute a violation of any judgment, injunction, order or decree binding upon
or applicable to either of Seller or the Purchased Assets which contravention,
conflict or violation would have a material adverse effect on the Purchased
Assets or their intended use; or (iv) result in the creation or imposition of
any Lien on any Purchased Asset.

     3.05. TITLE TO PURCHASED ASSETS. Upon consummation of the transactions
contemplated hereby, Buyer will have acquired good and marketable title in and
to each of the Purchased Assets, free and clear of all Liens.

     3.06. LITIGATION. With the sole exception of a notification of pending
interference from the PTO, there is no action, suit, investigation or proceeding
(or any basis therefor), of which Seller has received written notice, pending
or, to the knowledge of Seller, threatened, before any governmental authority or
arbitrator that has or could materially affect any Purchased Asset. Seller has
not received written notice of any claims made by any Person with respect to, or
any actions, suits or other proceedings relating to, any Purchased Assets which
would have a material adverse effect on the proposed or intended use of the
Purchased Assets.

     3.07. INTELLECTUAL PROPERTY. (a) There are no licenses, sublicenses or
other agreements relating to a Patent or Patent Application or Intellectual
Property.

     (b)  Seller has clear title to each Patent or Patent Application currently
issued or filed, including USSN 08/696,107. To its knowledge, Seller and each
inventor listed in any Patent or Patent Application and the attorneys of record
thereto have complied with the PTO duty of candor and good faith in dealing with
the PTO, including the duty to disclose to the PTO all information known to be
material to the patentability of each of the Patent Applications. Seller has all
necessary Patent Documentation underlying the specifications or claims in the
Patent Application and all claims thereunder. All assignments from Bluestone to,
as the case may

<PAGE>

be, Seller or to a predecessor in interest to Seller, have been executed and
either recorded with the PTO or submitted to the PTO for the Patent Application.

     3.10. FINDERS' FEES. There is no investment banker, broker, finder or other
intermediary which has been retained by or is authorized to act on behalf of
Seller who might be entitled to any fee or commission from Buyer or any of its
Affiliates upon consummation of the transactions contemplated by this Agreement.

     3.11. OTHER INFORMATION. Neither this Article 3 of this Agreement nor
either of the exhibits appended hereto contains any untrue statement of a
material fact or omits to state a material fact necessary in order to make the
statements contained herein or therein not misleading.

     3.12. INVESTMENT. Seller represents and warrants to Buyer that it is
acquiring the Shares, for investment purposes only, and not with a view to the
sale, assignment, transfer or other distribution thereof, other than in
compliance with the registration requirements of the Securities Act of 1933, as
amended (the "SECURITIES ACT"). Seller recognizes that the Shares have not been
registered under the Securities Act, and agrees that it will not sell, assign,
transfer, or otherwise distribute the Shares in violation of the Securities Act.

     3.13. INVESTIGATION. Seller represents and warrants to Buyer that it is
able to bear the economic risk of loss of its investment in the Shares, has been
granted the opportunity to make a thorough investigation of the affairs of
Buyer, and has availed itself of such opportunity either directly or through its
authorized representatives.

     3.14 RELIANCE BY SELLER. Seller represents and warrants to Buyer that it
has been advised that the Shares have not been and are not being registered
under the Securities Act or under the "blue sky" laws of any jurisdiction and
that the Buyer, in issuing the Shares to the Seller, is relying upon, among
other things, the representations and warranties of Seller contained in Sections
3.12-3.15 in concluding that such issuance is a "private offering" and does not
require compliance with the registration provisions of the Securities Act.

     3.15 LEGENDS. Seller understands and agrees that each certificate
representing the Shares delivered to Seller hereunder shall bear the legend
substantially as follows:

          "The shares represented hereby have not been registered under the
          Securities Act of 1933, as amended, and may not be sold or transferred
          unless the registration provisions of said Act have been complied with
          or unless in the opinion of counsel satisfactory to the Company both
          as to opinion and counsel compliance with such provisions is not
          required."

                                   ARTICLE IV

                     REPRESENTATIONS AND WARRANTIES OF BUYER

     Buyer hereby represents and warrants to the Seller that:

     4.01. ORGANIZATION AND EXISTENCE. Buyer is a company duly incorporated,
validly existing and in good standing under the laws of Delaware and has all
applicable powers and all material governmental licenses, authorizations,
consents and approvals required to carry on its business as now conducted.

     4.02. CORPORATE AUTHORIZATION. The execution, delivery and performance by
Buyer of this Agreement and each of the Conveyance Documents to which it is a
party and the consummation by Buyer of the transactions contemplated hereby and
thereby are within the powers of Buyer and have been duly authorized by all
necessary action on the part of Buyer. This Agreement has been duly executed and
delivered by the Buyer and constitutes a valid and binding agreement of Buyer.

<PAGE>

     4.03. GOVERNMENTAL AUTHORIZATION. The execution, delivery and performance
by Buyer of this Agreement and each of the Conveyance Documents to which it is a
party does not require any action by or in respect of, or filing with, any
Governmental Authority (other than the filing of patent assignments with the
PTO).

     4.04. NON-CONTRAVENTION. The execution, delivery and performance by Buyer
of this Agreement and each of the Conveyance Documents to which it is a party
does not and will not (i) contravene or conflict with the corporate charter or
by-laws of Buyer, (ii) contravene or conflict with or constitute a violation of
any provision of any law or regulation binding upon or applicable to Buyer; or
(iii) contravene or conflict with or constitute a violation of any judgment,
injunction, order or decree binding upon or applicable to Buyer.

     4.05. FINDERS' FEES. There is no investment banker, broker, finder or other
intermediary that has been retained by or is authorized to act on behalf of
Buyer who might be entitled to any fee or commission from Buyer upon
consummation of the transactions contemplated by this Agreement.

     4.06. LITIGATION. There is no action, suit, investigation or proceeding
pending against, or to the knowledge of Buyer threatened against or affecting,
Buyer before any court or arbitrator or any governmental body, agency or
official which in any matter challenges or seeks to prevent, enjoin, alter or
materially delay the transactions contemplated hereby or would have a material
adverse effect on Buyer's ability to perform its obligations under this
Agreement.

     4.07 OTHER INFORMATION. Article IV of this Agreement does not contain any
untrue statements of a material fact or omit to state a material fact necessary
in order to make the statements contained herein not misleading.

                                    ARTICLE V

                               COVENANTS OF SELLER

     5.01. CONFIDENTIALITY. Seller will hold, and will use reasonable commercial
efforts to cause its officers, directors, employees, accountants, counsel,
consultants, advisors and agents to hold, in confidence, unless compelled to
disclose by judicial or administrative process or by other requirements of law,
all confidential documents and information concerning Buyer or the Purchased
Assets, which information shall be identified in writing as confidential or, if
delivered orally, confirmed in writing as confidential within 30 days after
delivery.

     5.02. ATTORNEY OF RECORD. As promptly as practicable after the Closing, but
in any event within 30 days after the Closing, Seller shall take all necessary
actions to name Peter Fasse, Esq., of Fish and Richardson, as attorney of record
for the Patent Applications, provided that Buyer, at Buyer's expense, prepares
and submits to Seller for execution the documents appropriate to effect the
foregoing.

     5.03. PATENT DOCUMENTATION. Upon request of Buyer, Seller shall promptly
deliver to Buyer a copy of all Patent Documentation.

     5.04. PUBLICITY. Seller covenants and agrees that the Seller will not issue
any press releases or engage in any other publicity activities with respect to
any information regarding or relating to this Agreement or any transactions
related hereto, without the prior written consent of Buyer.

                                   ARTICLE VI

                               COVENANTS OF BUYER

<PAGE>

     6.01. DILIGENT MAINTENANCE OF PURCHASED ASSETS. For so long as Buyer holds
title to the Patent Application, Buyer will use reasonable commercial efforts to
prosecute the Patent Application, including litigating an interference
proceeding, and to secure the issuance of those claims pending (with respect to
such Patent Application) as of the Closing Date to the extent such claims are
supported by the specification of the Patent Application. Buyer further will use
reasonable commercial efforts to enforce and defend any patents which issue
forth from the Patent Application.

     6.02. CONVEYANCE OF RIGHTS IN EVENT OF NON-PAYMENT OF CONTINGENT PAYMENT.
Subject to the terms herein, Buyer hereby covenants and agrees to pay the
Contingent Payment to Seller (a) no later than within 10 business days after May
9, 2001, or (b) if any events set forth in Section 2.02(c)(i) - 2.02(c)(iv)
occur prior to May 9, 2001, within 10 business days of the date Buyer becomes
aware (whether by notice of Seller or otherwise) of such Contingent Payment Due
Date arising out of Sections 2.02(c)(i) - 2.02(c)(iv). In the event Buyer has
elected to not make or has failed to make the Contingent Payment in accordance
with the terms herein, Buyer will convey and deliver all instruments, documents,
and certificates required by Seller to recover to the fullest extent possible,
all right, title, and interest in and to the Purchased Assets.

     6.03. GRANT OF LICENSE IN THE EVENT OF NON-USE OF PURCHASED ASSETS. Buyer
will use reasonable commercial efforts to commercially develop technology
related to the Purchased Assets for so long as Buyer holds rights to the
Purchased Assets, which commercial development may include the license or sale
of rights to one or more third parties of the Purchased Assets. Buyer shall,
upon request of Seller, provide written reports describing Buyer's efforts to
commercially develop the property. Buyer, in its sole discretion, may elect to
cease efforts to commercially develop technology related to the Purchased
Assets, provided that such cessation of efforts must be documented and approved
by the executive officers of Buyer. Buyer shall notify Seller of such election
within thirty (30) days of such election. In the event of such an election and
provided that Buyer has paid in full its Contingent Payment (if due) in
accordance with the terms herein and has not previously granted rights to any
unrelated third party to develop such technology, Buyer will grant to Seller a
license to practice under the Purchased Assets in accordance with this Section
6.03 and Section 7.03. Such license to practice under the Purchased Assets shall
be exclusive and able to be sublicensed by Seller, but Buyer shall retain the
first right to prosecute, enforce and defend any patents and patent applications
contained within the Purchased Assets. Buyer and Seller agree to enter into a
separate agreement according to Section 7.03 herein which shall govern such
license.

                                   ARTICLE VII

                          COVENANTS OF BUYER AND SELLER

     7.01. EFFORTS; FURTHER ASSURANCES. (a) Subject to the terms and conditions
of this Agreement, each party will use its commercially reasonable efforts to
take, or cause to be taken, all actions and to do, or cause to be done, all
things necessary under applicable laws and regulations to consummate the
transactions contemplated by this Agreement; Seller and Buyer agree to execute
and deliver such other documents, certificates, agreements and other writings
and to take such other actions as may be necessary in order to consummate or
implement expeditiously the transactions contemplated by this Agreement and to
vest in Buyer good and marketable title to the Purchased Assets.

     (b)  Without limiting the foregoing, Seller further agrees for itself
and its successors and assigns to execute upon request any other lawful
documents and likewise to perform any other lawful acts which may be necessary
or desirable to secure fully for Buyer all right, title and interest in and to
each of the Purchased Assets, including, but not limited to, the execution of
substitution, reissue, divisional or continuation patent applications; and
preliminary or other statement or the giving of testimony in any interference or
other proceeding in which the Purchased Assets or any applications or patent
directed thereto or derived therefrom may be involved. Seller agrees (i) to
provide such reasonable assistance to Buyer as Buyer may request in

<PAGE>

connection with the prosecution of the Patent Applications and any action
against third parties claiming infringement of any of the Purchased Assets and
(ii) never to contest or assist any third party in contesting the validity or
enforceability of any Valid Claim. However, Seller and its Affiliates may comply
with any and all court orders (if requested) and provide testimony relating to
any and all matters relating to the Purchased Assets in any proceeding,
deposition, or trial, which testimony is believed to be factually correct by
Seller or its Affiliates, without in any way being held to "contest or assist
any third party in contesting the validity or enforcability of any Valid Claim."
In the event that Dr. Jeff Bluestone, Mr. David Epstein or any other Affiliate
of Seller is requested by Buyer to devote and does actually devote more than 4
days each (it being understood that four hours shall be considered a full day)
to any prosecution, interference, or litigation relating to the Purchased
Assets, that person shall be compensated for his time at the rate of Two Hundred
Dollars ($200.00) per hour (if under four hours for any one day) or $1,600 per
day, plus actual reasonable expenses, as approved in advance by Buyer. Further,
upon request, Buyer shall provide legal counsel to represent Dr. Jeff Bluestone,
Mr. David Epstein or any other Seller Affiliate in conjunction with the giving
of written or oral testimony in regard to any prosecution, interference, or
litigation relating to the Purchased Assets.

     (c)  Seller hereby constitutes and appoints, effective as of the Closing
upon payment of the Purchase Price, Buyer and its successors and assigns as the
true and lawful attorney of such Seller with full power of substitution in the
name of Buyer or in the name of such Seller, but for the benefit of Buyer (i) to
collect for the account of Buyer any items of Purchased Assets and (ii) to
prosecute all proceedings which Buyer may in its sole discretion deem proper in
order to assert or enforce any right, title or interest in, to or under the
Purchased Assets, and to defend or compromise any and all actions, suits or
proceedings in respect of the Purchased Assets, whether based on a claim arising
prior to or after the Closing Date. Buyer shall be entitled to retain for its
account any amounts collected pursuant to the foregoing powers, including any
amounts payable as interest in respect thereof.

     (d) Subject to Section 10.03 hereof, Buyer shall pay all expenses incurred
by Seller from and after the Closing Date in complying with this Section 7.01
provided that such expenses are incurred at the request of Buyer or approved in
advance by Buyer (which approval shall not be unreasonably withheld or delayed).

     7.02. CONFIDENTIALITY. Buyer and Seller agree not to disclose the terms of
any agreement between them or directly or indirectly identify the other parties
in a press release, news letter, electronic communication, shareholder letter or
other public disclosure without prior permission except to the extent that the
information is in the public domain or the disclosure is required by law or
government agency. Notwithstanding the foregoing, the parties acknowledge that
Buyer may issue a press release announcing the transactions contemplated by this
Agreement after execution of this Agreement.

     7.03 FURTHER AGREEMENT. In the event that Buyer grants a license to Seller
pursuant to Section 6.02, Buyer and Seller will enter an agreement which governs
such license. The terms and conditions of such license not set forth in Section
6.02 shall be negotiated in good faith by the parties. Notwithstanding anything
to the contrary herein, any royalty rates or royalty payments established under
the license agreement entered into between Buyer and Seller pursuant to Section
6.02 and 7.03 herein shall be reasonably consistent with applicable industry
standards and shall be the only license fees or related cash payments payable by
Seller to Buyer thereunder.

                                  ARTICLE VIII

                            SURVIVAL; INDEMNIFICATION

     8.01. SURVIVAL. The representations and warranties of the parties hereto
contained in this Agreement or in any certificate or other writing delivered
pursuant hereto or in connection herewith shall survive the Closing for a period
of two years except to the extent limited by Section 8.03; PROVIDED that the
agreements in Articles V through VIII shall survive the Closing until the
expiration of this Agreement pursuant to Article IX; provided further that
Section 6.02 and Article X shall survive any such termination of this Agreement.
Notwithstanding anything to the contrary herein, Section 6.02 shall terminate
and be of no

<PAGE>

further force or effect if Buyer pays to the Seller the Contingent Payment in
full at anytime prior to or on the Contingent Payment Due Date.

     8.02. INDEMNIFICATION. (a) Subject to the limitations set forth in Section
8.03, Seller hereby indemnifies Buyer and Buyer's Affiliates against and agree
to hold each of them harmless from any and all damage, loss, liability and
expense (including, without limitation, reasonable expenses of investigation and
reasonable attorneys' fees and expenses in connection with any action, suit or
proceeding) (collectively, "LOSS") incurred or suffered by Buyer or any of its
Affiliates arising out of any misrepresentation or breach of warranty, covenant
or agreement made or to be performed by Seller pursuant to this Agreement.

     (b)  Subject to the terms herein, Buyer hereby indemnifies Seller and any
of Seller's Affiliates against and agrees to hold each of them harmless from any
and all Loss incurred or suffered by Seller or any of Seller's Affiliates
arising out of:

          (i)  any misrepresentation or breach of warranty, covenant or
agreement made or to be performed by Buyer pursuant to this Agreement; or

          (ii) any product liability, adverse reactions or injury from the use
of any product manufactured by or for Buyer or tested in a clinical study
sponsored or licensed by Buyer which is covered by a Valid Claim.

     8.03. PROCEDURES; NO WAIVER; EXCLUSIVITY. The party seeking indemnification
under Section 8.02 (the "INDEMNIFIED PARTY") agrees to give prompt notice to the
party against whom indemnity is sought (the "INDEMNIFYING PARTY") of the
assertion of any claim, or the commencement of any suit, action or proceeding in
respect of which indemnity may be sought under such Section; PROVIDED that the
failure to give such notice shall not affect the Indemnified Party's rights
hereunder except to the extent the Indemnifying Party is materially prejudiced
by such failure. The Indemnifying Party may, and at the request of the
Indemnified Party shall, participate in and control the defense of any such
third party suit, action or proceeding at its own expense. The Indemnifying
Party shall not be liable under Section 8.02 for any settlement effected without
its prior written consent of any claim, litigation or proceeding in respect of
which indemnity may be sought hereunder; PROVIDED that such written consent may
not be unreasonably withheld.

     After the Closing, subject to the terms herein, Section 8.02 will provide
the exclusive remedy for Buyer for any misrepresentation, breach of warranty,
covenant or other agreement by Seller or other claim by Buyer arising out of
this Agreement or the transactions contemplated hereby.

     8.04. CERTAIN REMEDIES. Notwithstanding anything to the contrary herein, in
the event that Seller has a claim against Buyer arising out of a material
violation of the terms of Section 6.02(a) or 6.03 of this Agreement as to the
Purchased Assets, and with respect only to Section 6.03, Buyer shall have failed
to cure such material violation under section 6.03 ninety (90) days after
written notice from Seller of such material violation, Seller's sole and
exclusive remedy shall be to recover from Buyer the Purchased Assets. As to any
other misrepresentation, breach of warranty, covenant or other agreement or
other claim arising out of any material violation of this Agreement by Buyer,
Seller shall be entitled to any remedy available at law or in equity.

     8.05. LIMITATIONS OF LIABILITY. EXCEPT IN THE EVENT OF FRAUD, UNDER NO
CIRCUMSTANCES SHALL EITHER PARTY BE LIABLE TO THE OTHER PARTY OR ANY OTHER
PERSON FOR ANY LOSS OF PROFITS OR SPECIAL, CONSEQUENTIAL OR INDIRECT DAMAGES OF
ANY KIND WHATSOEVER.

     8.06. FORCE MAJEURE. No party shall be liable for failure or delay in
performing any of its obligations hereunder if such failure or delay is
occasioned by compliance with any governmental regulation, request or order, or
by circumstances beyond the reasonable control of the party so failing or
delaying, including, without limitation, Acts of God, war, insurrection, fire,
flood, accident, labor strikes, work

<PAGE>

stoppage or slowdown (whether or not such labor event is within the reasonable
control of the parties), or inability to obtain raw materials, supplies, power
or equipment necessary to enable such party to perform its obligations
hereunder. Each party shall (a) promptly notify the other party in writing of
any such event of force majeure, the expected duration thereof and its
anticipated effect on the ability of such party to perform its obligations
hereunder, and (b) make reasonable efforts to remedy any such event of force
majeure.

                                   ARTICLE IX

                                   TERMINATION

     9.01. TERMINATION. This Agreement shall terminate upon either of i) the
expiration of the last to expire Valid Claim, or ii) the receipt of written
notification by Seller of Buyer's election not to pay in full the Contingent
Payment by the Contingent Payment Due Date or (iii) the actual failure of Buyer
to pay in full the Contingent Payment upon the occurrence of the Contingent
Payment Due Date in accordance with the terms herein.

     9.02. EFFECT OF TERMINATION. If this Agreement is terminated pursuant to
Section 9.01, such termination shall be without liability of any party (or any
stockholder, director, officer, employee, agent, consultant or representative of
such party) to any other party to this Agreement.

                                    ARTICLE X

                                  MISCELLANEOUS

     10.01. NOTICES. All notices, requests and other communications to either
party hereunder shall be in writing (including telex, telecopy or similar
writing with confirmed receipt of transmission) and shall be given,

     (a)  if to Buyer, to:

          Repligen Corporation
          117 Fourth Avenue
          Needham, MA  02494
          Attention:        Walter Herlihy
                            Daniel Witt
          Telecopy:         (781) 453-0048

          with a copy to:

          Testa, Hurwitz & Thibeault, LLP
          High Street Tower
          125 High Street
          Boston, MA  02110
          Attention:        Lawrence S. Wittenberg, Esq.
          Telecopy:         (617) 248-7100

     (b)  if to Seller, to:

          Tolerance Therapeutics LLC
          Suite 3N
          5490 South Shore Drive
          Chicago, IL 60615
          Attention:  David Epstein

<PAGE>

          Telecopy:  (773) 324-7071

or to such other address as any party may have furnished to the others in
writing in accordance herewith, except that notices of change of address shall
only be effective upon receipt. All notices and other communications given to
any party hereto in accordance with the provisions of this Agreement shall be
deemed to have been given on the date of receipt if delivered by hand or
overnight courier service or sent by fax prior to 4:00 p.m. EST or on the date
five business days after dispatch by certified or registered mail if mailed, in
each case delivered, sent or mailed (properly addressed) to such party as
provided in this Section 10.01.

     10.02. AMENDMENTS; NO WAIVERS. (a) Any provisions of this Agreement may be
amended or waived if, and only if, such amendment or waiver is in writing and
signed, in the case of an amendment, by Buyer and Seller, or in the case of a
waiver, by the party against whom the waiver is to be effective.

     (b)  No failure or delay by either party in exercising any right, power or
privilege hereunder shall operate as a waiver thereof nor shall any single or
partial exercise thereof preclude any other or further exercise thereof or the
exercise of any other right, power or privilege. Except to the extent expressly
provided otherwise in this Agreement, the rights and remedies herein provided
shall be cumulative and not exclusive of any rights or remedies provided by law.

     10.03. EXPENSES. All costs and expenses incurred in connection with the
negotiation, preparation, execution or delivery of this Agreement shall be paid
by the party incurring such cost or expense.

     10.04. SUCCESSORS AND ASSIGNS. The provisions of this Agreement shall be
binding upon and inure to the benefit of the parties hereto and their respective
successors and assigns. No party to this Agreement shall assign any rights under
this Agreement to any party without the written consent of the other parties
hereto except that nothing herein shall prohibit or restrict Buyer from
assigning its rights and obligations hereunder to any Affiliate of Buyer.

     10.05. GOVERNING LAW; JURISDICTION. This Agreement shall be construed in
accordance with and governed by the law of the Commonwealth of Massachusetts and
the United States of America. Process in any such suit, action or proceeding may
be served on any party anywhere in the world, whether within or without the
jurisdiction of any such court.

     10.06. COUNTERPARTS; EFFECTIVENESS. This Agreement may be signed in any
number of counterparts, each of which shall be an original, with the same effect
as if the signatures thereto and hereto were upon the same instrument. This
Agreement shall become effective on the date of signature of the last party to
sign this Agreement.

     10.07. ENTIRE AGREEMENT. This Agreement, the Exhibits hereto, the Schedules
and the Conveyance Documents constitute the entire agreement between the parties
with respect to the subject matter hereof and supersede all prior agreements,
understandings and negotiations, both written and oral, between the parties with
respect to the subject matter of this Agreement. No representation, inducement,
promise, understanding, condition or warranty not set forth or referred to
herein has been made or relied upon by either party hereto. Neither of this
Agreement, nor any provision hereof, is intended to confer upon any Person other
than the parties hereto any rights or remedies hereunder.

     10.08. CAPTIONS. The captions herein are included for convenience of
reference only and shall be ignored in the construction or interpretation
hereof.

     10.09 SEVERABILITY. If any provision of this Agreement shall be held to be
illegal, invalid or unenforceable, such illegality, invalidity or
unenforceability shall attach only to such provision and shall not in any manner
affect or render illegal, invalid or unenforceable any other provision of this
Agreement, and this

<PAGE>

Agreement shall be carried out as if any such illegal, invalid or unenforceable
provision were not contained herein.

                     [SIGNATURE PAGE TO FOLLOW IMMEDIATELY]

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed by their respective authorized officers as of the day and year
first above written.

                                     REPLIGEN CORPORATION

                                     By: /s/ DANIEL P. WITT
                                         -----------------
                                     Name: Daniel P. Witt
                                     Title: VP Business Development
                                     Date: May 9, 2000

                                     TOLERANCE THERAPEUTICS LLC

                                     By: /s/DAVID EPSTEIN
                                         ---------------
                                     Name: DAVID EPSTEIN
                                     Title: Manager
                                     Date: May 9, 2000<PAGE>

                                                                    Exhibit 10.1

                       INVERNESS MEDICAL TECHNOLOGY, INC.
                                     FORM OF
                        2000 STOCK OPTION AND GRANT PLAN

SECTION 1. GENERAL PURPOSE OF THE PLAN: DEFINITIONS
           ----------------------------------------

     The name of the plan is the Inverness Medical Technology, Inc. 2000 Stock
Option and Grant Plan (the "Plan"). The purpose of the Plan is to encourage and
enable the officers, employees, Directors and other key persons of Inverness
Medical Technology, Inc, (the "Company") and its Subsidiaries upon whose
judgment, initiative and efforts the Company largely depends for the successful
conduct of its business to acquire a proprietary interest in the Company. It is
anticipated that providing such persons with a direct stake in the Company's
welfare will assure a closer identification of their interests with those of the
Company, thereby stimulating their efforts on the Company's behalf and
strengthening their desire to remain with the Company.

     The following terms shall be defined as set forth below:

     "ACT" means the Securities Exchange Act of 1934, as amended.

     "ADMINISTRATOR" means a committee of two or more Non-Employee Directors
appointed by the Board to administer the Plan.

     "AWARD" or "AWARDS", except where referring to a particular category of
grant under the Plan, shall include Incentive Stock Options, Non-Qualified Stock
Options, Stock Appreciation Rights, Restricted Stock Awards, Unrestricted Stock
Awards, Performance Share Awards and Dividend Equivalent Rights.

     "BOARD" means the Board of Directors of the Company.

     "CAUSE" as such term relates to the termination of any person means the
occurrence of one or more of the following: (i) such person is convicted of,
pleads guilty to, or confesses to any felony or any act of fraud,
misappropriation or embezzlement which has an immediate and materially adverse
effect on the Company or any Subsidiary, as determined by the Board in good
faith in its sole discretion, (ii) such person engages in a fraudulent act to
the material damage or prejudice of the Company or any Subsidiary or in conduct
or activities materially damaging to the property, business or reputation of the
Company or any Subsidiary, all as determined by the Board in good faith in its
sole discretion, (iii) any material act or omission by such person involving
malfeasance or negligence in the performance of such person's duties to the
Company or any Subsidiary to the material detriment of the Company or any
Subsidiary, as determined by the Board in

<PAGE>

good faith in its sole discretion, which has not been corrected by such person
to the satisfaction of the Board within 30 days after written notice from the
Company of any such act or omission, (iv) failure by such person to comply in
any material respect with the terms of his employment agreement, if any, or any
written policies or directives of the Board as determined by the Board in good
faith in its sole discretion, which noncompetition agreement with the Company,
if any, as determined by the Board in good faith in its sole discretion.

     "CHANGE OF CONTROL" is defined in Section 15.

     "CODE" means the Internal Revenue Code of 1986, as amended, and any
successor Code, and related rules, regulations and interpretations.

     "DISABILITY" means an individual's inability to perform his normal required
services for the Company and its Subsidiaries for a period of six consecutive
months by reason of the individual's mental or physical disability, as
determined by the Administrator in good faith in its sole discretion.

     "DIVIDEND EQUIVALENT RIGHT" means Awards granted pursuant to Section 10.

     "EFFECTIVE DATE" means the date on which the Plan is approved by
stockholders as set forth in Section 17.

     "FAIR MARKET VALUE" on any given date means the last reported sale price at
which Stock is traded on such date or, if no Stock is traded on such date, the
next preceding date on which Stock was traded, as reflected on the principal
stock exchange or, if applicable, any other national stock exchange on which the
Stock is traded or admitted to trading.

     "INCENTIVE STOCK OPTION" means any Stock Option designated and qualified as
an incentive stock option" as defined in Section 422 of the Code.

     "NON-EMPLOYEE DIRECTOR" means any Director who is both a "Non-Employee
Director" within the meaning of Rule 16b-3(b)(3)(i) promulgated under the Act,
or any successor definition under said rule, and an "outside director" within
the meaning of Section 162(m) of the Code and the regulations promulgated
thereunder.

     "NON-QUALIFIED STOCK OPTION" means any Stock Option that is not an
Incentive Stock Option

     "OPTION" or "STOCK OPTION" means any option to purchase shares of Stock
granted pursuant to Section 5.

     "PERFORMANCE SHARE AWARD" means Awards granted pursuant to Section 9.

     "RESTRICTED STOCK AWARD" means Awards granted pursuant to Section 7.

                                       2
<PAGE>

     "RETIREMENT" means the employee's termination of employment with the
Company and its Subsidiaries after attainment of age 65 or attainment of age 55
and completion of 10 years of employment.

     "STOCK" means the Common Stock, par value $.001 per share, of the Company,
subject to adjustments pursuant to Section 3.

     "STOCK APPRECIATION RIGHT" means any Award granted pursuant to Section 6.

     "SUBSIDIARY" means any corporation or other entity (other than the Company)
in any unbroken chain of corporations or other entities, beginning with the
Company if each of the corporations or entities (other than the last corporation
or entity in the unbroken chain) owns stock or other interests possessing 50% or
more of the economic interest or the total combined voting power of all classes
of stock or other interests in one of the other corporations or entities in the
chain.

     "UNRESTRICTED STOCK AWARD" means any Award granted pursuant to Section 8.

SECTION 2. ADMINISTRATION OF PLAN: AUTHORITY TO SELECT PARTICIPANTS AND
           ------------------------------------------------------------
           DETERMINE AWARDS
           ----------------

     (a) POWERS OF ADMINISTRATOR. The Administrator shall have the power and
authority to grant Awards consistent with the terms of the Plan, including the
power and authority:

          (i) to select the officers, employees and key persons of the Company
     and its Subsidiaries to whom Awards may from time to time be granted;

          (ii) to determine the time or times of grant, and the extent, if any,
     of Incentive Stock Options, Non-Qualified Stock Options, Stock Appreciation
     Rights, Restricted Stock Awards, Unrestricted Stock Awards, Performance
     Share Awards and Dividend Equivalent Rights, or any combination of the
     foregoing, granted to any one or more participants;

          (iii) to determine the number of shares of Stock to be covered by any
     Award;

          (iv) to determine and modify from time to time the terms and
     conditions, including restrictions, not inconsistent with the terms of the
     Plan, of any Award, which terms and conditions may differ among individual
     Awards and participants, and to approve the form of written instruments
     evidencing the Awards;

          (v) to accelerate at any time the exercisability or vesting of all or
     any portion of any Award;

                                       3
<PAGE>

          (vi) subject to the provisions of Section 5(a)(iii), to extend at any
     time the period in which Stock Options may be exercised;

          (vii) to determine at any time whether, to what extent, and under what
     circumstances Stock and other amounts payable with respect to an Award
     shall be deferred either automatically or at the election of the
     participant and whether and to what extent the Company shall pay or credit
     amounts constituting interest (at rates determined by the Administrator) or
     dividends or deemed dividends on such deferrals; and

          (viii) at any time to adopt, alter and repeal such rules, guidelines
     and practices for administration of the Plan and for its own acts and
     proceedings as it shall deem advisable; to interpret the terms and
     provisions of the Plan and any Award (including related written
     instruments); to make all determinations it deems advisable for the
     administration of the Plan; to decide all disputes arising in connection
     with the Plan; and to otherwise supervise the administration of the Plan.

     All decisions and interpretations of the Administrator shall be binding on
all persons, including the Company and Plan participants.

     (b) DELEGATION OF AUTHORITY TO GRANT AWARDS. The Administrator, in its
discretion, may delegate to the Chief Executive Officer of the Company all or
part of the Administrator's authority and duties with respect to Awards,
including the granting thereof, to individuals who are not subject to the
reporting and other provisions of Section 16 of the Act or "covered employees"
within the meaning of Section 162(m) of the Code. The Administrator may revoke
or amend the terms of a delegation at any time but such action shall not
invalidate any prior actions of the Administrator's delegate or delegates that
were consistent with the terms of the Plan.

SECTION 3. STOCK ISSUABLE UNDER THE PLAN MERGERS: SUBSTITUTION
           ---------------------------------------------------

     (a) STOCK ISSUABLE. The maximum number of shares of Stock reserved and
available for issuance under the Plan shall be 750,000 shares. For purposes of
this limitation, the shares of Stock underlying any Awards which are forfeited,
cancelled, reacquired by the Company, satisfied without the issuance of Stock or
otherwise terminated (other than by exercise) shall be added back to the shares
of Stock available for issuance under the Plan. Subject to such overall
limitation, shares of Stock may be issued up to such maximum number pursuant to
any type or types of Award; provided, however, that Stock Options or Stock
Appreciation Rights with respect to no more than 500,000 shares of Stock may be
granted to any one individual participant during any one calendar year period.
The shares available for issuance under the Plan may be authorized but unissued
shares of Stock or shares of Stock reacquired by the Company. Upon the exercise
of a Stock Appreciation Right settled in shares of Stock, the right to purchase
an equal number of shares of Stock covered by a related Stock Option, if any,
shall be deemed to

                                       4
<PAGE>

have been surrendered and will no longer be exercisable, and
said number of shares of Stock shall no longer be available under the Plan.

     (b) RECAPITALIZATIONS. If, through or as a result of any merger,
consolidation, sale of all or substantially all of the assets of the Company,
reorganization, recapitalization, reclassification, stock dividend, stock split,
reverse stock split or other similar transaction, the outstanding shares of
Stock are increased or decreased or are exchanged for a different number or kind
of shares or other securities of the Company, or additional shares or new or
different shares or other securities of the Company or other non-cash assets are
distributed with respect to such shares of Stock or other securities, the
Administrator shall make an appropriate or proportionate adjustment in (i) the
maximum number of shares reserved for issuance under the Plan, (ii) the number
of Stock Options or Stock Appreciation Rights that can be granted to any one
individual participant, (iii) the number and kind of shares or other securities
subject to any then outstanding Awards under the Plan, and (iv) the price for
each share subject to any then outstanding Stock Options and Stock Appreciation
Rights under the Plan, without changing the aggregate exercise price (i.e., the
exercise price multiplied by the number of Stock Options and Stock Appreciation
Rights) as to which such Stock Options and Stock Appreciation Rights remain
exercisable. The adjustment by the Administrator shall be final, binding and
conclusive. No fractional shares of Stock shall be issued under the Plan
resulting from any such adjustment, but the Administrator in its discretion may
make a cash payment in lieu of fractional shares.

     (c) MERGERS. Upon consummation of a consolidation or merger or sale of all
or substantially all of the assets of the Company in which outstanding shares of
Stock are exchanged for securities, cash or other property of an unrelated
corporation or business entity or in the event of a liquidation of the Company,
the Board, or the board of directors of any corporation assuming the obligations
of the Company, may, in its discretion, take any one or more of the following
actions, as to outstanding Stock Options and Stock Appreciation Rights: (i)
provide that such Stock Options shall be assumed or equivalent options shall be
substituted, by the acquiring or succeeding corporation (or an affiliate
thereof), (ii) upon written notice to the optionees, provide that all
unexercised Stock Options and Stock Appreciation Rights will terminate
immediately prior to the consummation of such transaction unless exercised by
the optionee within a specified period following the date of such notice, and/or
(iii) in the event of a business combination under the terms of which holders of
the Stock of the Company will receive upon consummation thereof a cash payment
for each share surrendered in the business combination, make or provide for a
cash payment to the optionees equal to the difference between (A) the value (as
determined by the Administrator) of the consideration payable per share of Stock
pursuant to the business combination (the "Merger Price") times the number of
shares of Stock subject to such outstanding Stock Options and Stock Appreciation
Rights (to the extent then exercisable at prices not in excess of the Merger
Price) and (B) the aggregate exercise price of all such outstanding Stock
Options and Stock Appreciation Rights in exchange for the termination of such
Stock Options and Stock Appreciation Rights.

                                       5
<PAGE>

         (d) SUBSTITUTE AWARDS. The Administrator may grant Awards under the
Plan in substitution for stock and stock based awards held by employees of
another corporation who become employees of the Company or a Subsidiary as the
result of a merger or consolidation of the employing corporation with the
Company or a Subsidiary or the acquisition by the Company or a Subsidiary of
property or stock of the employing corporation. The Administrator may direct
that the substitute awards be granted on such terms and conditions as the
Administrator considers appropriate in the circumstances.

SECTION 4. ELIGIBILITY
           -----------

     Participants in the Plan will be such full or part-time officers, other
employees, Directors and other key persons of the Company and its Subsidiaries
who are responsible for or contribute to the management, growth or profitability
of the Company and its Subsidiaries as are selected from time to time by the
Administrator, in its sole discretion.

SECTION 5. STOCK OPTIONS
           -------------

     Any Stock Option granted under the Plan shall be in such form as the
Administrator may from time to time approve.

     Stock Options granted under the Plan may be either Incentive Stock Options
or Non-Qualified Stock Options. Incentive Stock Options may be granted only to
employees of the Company or any Subsidiary that is a "subsidiary corporation"
within the meaning of Section 424(f) of the Code. To the extent that any Option
does not qualify as an Incentive Stock Option, it shall be deemed a
Non-Qualified Stock Option.

     No Incentive Stock Option shall be granted under the Plan after March 7,
2010  [(10 years from the date plan is approved by Board of Directors)].

     (a) TERMS AND CONDITIONS OF STOCK OPTIONS. The Administrator in its
discretion may grant Stock Options subject to the following terms and conditions
and such additional terms and conditions, not inconsistent with the terms of the
Plan, as the Administrator shall deem desirable:

          (i) EXERCISE PRICE. The exercise price per share for the Stock covered
     by a Stock Option granted pursuant to this Section 5(a) shall be determined
     by the Administrator at the time of grant but shall not be less than 100%
     of the Fair Market Value on the date of grant in the case of Incentive
     Stock Options, or 85% of the Fair Market Value on the date of grant, in the
     case of Non-Qualified Stock Options. Notwithstanding the foregoing, with
     respect to Non-Qualified Stock Options which are granted in lieu of
     compensation, the exercise price per share shall not be less than 50% of
     the Fair Market Value on the date of grant. If an employee owns or is
     deemed to own by reason of the attribution rules of Section 424(d) of the
     Code) more than 10% of the combined voting power of all classes of stock of
     the Company or any parent or subsidiary corporation and an Incentive

                                       6
<PAGE>

     Stock Option is granted to such employee, the option price of such
     Incentive Stock Option shall be not less than 110% of the Fair Market Value
     on the grant date.

          (ii) GRANT OF DISCOUNT OPTIONS IN LIEU OF CASH BONUS. Upon the request
     of a participant and with the consent of the Administrator, such
     participant may elect each calendar year to receive a Non-Qualified Stock
     Option in lieu of any specified compensation to which he may become
     entitled during the following calendar year pursuant to any other plan or
     arrangement of the Company, but only if such participant makes an advance
     election to waive receipt of all or a portion of such compensation. Such
     election shall be made on or before the date set by the Administrator which
     date generally shall be no later than 15 days (or such shorter period
     permitted by the Administrator) preceding January 1 of the calendar year
     for which the compensation would otherwise be paid. A Non-Qualified Stock
     Option shall be granted to each employee who made such an election on the
     date the waived compensation would otherwise be paid. The exercise price
     per share shall be determined by the Administrator but shall not be less
     than 50% of the Fair Market Value of the Stock on the date the Stock Option
     is granted. The number of shares of Stock subject to the Stock Option shall
     be determined by dividing the amount of the waived compensation by the
     difference between the Fair Market Value of the Stock on the date the Stock
     Option is granted and the exercise price per Stock Option. The Stock Option
     shall be granted for whole number of shares so determined; the value of any
     fractional share shall be paid in cash.

          (iii) OPTION TERM. The term of each Stock Option shall be fixed by the
     Administrator, but no Incentive Stock Option shall be exercisable more than
     ten years after the date the option is granted. If an employee owns or is
     deemed to own (by reason of the attribution rules of Section 424(d) of the
     Code) more than 10% of the combined voting power of all classes of stock of
     the Company or any parent or subsidiary corporation and an Incentive Stock
     Option is granted to such employee, the term of such option shall be no
     more than five years from the date of grant.

          (iv) EXERCISABILITY: RIGHTS OF A STOCKHOLDER. Stock Options shall
     become vested and exercisable at such time or times, whether or not in
     installments, as shall be determined by the Administrator at or after the
     grant date; provided, however, that Stock Options granted in lieu of
     compensation shall be exercisable in full as of the grant date. The
     Administrator may at any time accelerate the exercisability of all or any
     portion of any Stock Option. An optionee shall have the rights of a
     stockholder only as to shares acquired upon the exercise of a Stock Option
     and not as to unexercised Stock Options.

          (v) METHOD OF EXERCISE. Stock Options may be exercised in whole or in
     part, by giving written notice of exercise to the Company, specifying the
     number of shares to be purchased. Payment of the purchase price may be made
     by one or more of the following methods:

                                       7
<PAGE>

               (A) In cash, by certified or bank check or other instrument
          acceptable to the Administrator;

               (B) In the form of shares of Stock that are not then subject to
          restrictions under any Company plan and that have been beneficially
          owned by the optionee for at least six months, if permitted by the
          Administrator in its discretion. Such surrendered shares shall be
          valued at Fair Market Value on the exercise date; or

               (C) By the optionee delivering to the Company a properly executed
          exercise notice together with irrevocable instructions to a broker to
          promptly deliver to the Company cash or a check payable and acceptable
          to the Company to pay the purchase price; provided that in the event
          the optionee chooses to pay the purchase price as so provided, the
          optionee and the broker shall comply with such procedures and enter
          into such agreements of indemnity and other agreements as the
          Administrator shall prescribe as a condition of such payment
          procedure.

Payment instruments will be received subject to collection. The delivery of
certificates representing the shares of Stock to be purchased pursuant to the
exercise of a Stock Option will be contingent upon receipt from the optionee (or
a purchaser acting in his stead in accordance with the provisions of the Stock
Option) by the Company of the full purchase price for such shares and the
fulfillment of any other requirements contained in the Stock Option or
applicable provisions of laws.

          (vi) TERMINATION BY REASON OF DEATH. Any Stock Option held by an
     optionee whose employment by (or other business relationship with) the
     Company and its Subsidiaries is terminated by reason of death shall become
     fully exercisable and may thereafter be exercised by the legal
     representative or legatee of the optionee, for a period of 12 months (or
     such longer period as the Administrator shall specify at any time) from the
     date of death, or until the expiration of the stated term of the Option, if
     earlier.

          (vii) TERMINATION BY REASON OF DISABILITY

               (A) Any Stock Option held by an optionee whose employment by (or
          other business relationship with) the Company and its Subsidiaries is
          terminated by reason of Disability shall become fully exercisable and
          may thereafter be exercised, for a period of 12 months (or such longer
          period as the Administrator shall specify at any time) from the date
          of such termination of employment (or business relationship), or until
          the expiration of the stated term of the Option, if earlier.

                                       8
<PAGE>

               (B) The Administrator shall have sole authority and discretion to
          determine whether a participant's employment (or business
          relationship) has been terminated by reason of Disability.

               (C) Except as otherwise provided by the Administrator at any
          time, the death of an optionee during the period provided in this
          Section 5(a)(vii) for the exercise of a Stock Option shall extend such
          period for 12 months from the date of death, subject to termination on
          the expiration of the stated term of the Option, if earlier.

          (viii) TERMINATION BY REASON OF RETIREMENT.

               (A) Any Stock Option held by an optionee whose employment by (or
          business relationship with) the Company and its Subsidiaries is
          terminated by reason of Retirement may thereafter be exercised, to the
          extent it was exercisable at the time of such termination, for a
          period of 12 months (or such other period as the Administrator shall
          specify at any time) from the date of such termination of employment
          (or business relationship), or until the expiration of the stated term
          of the Option, if earlier.

               (B) Except as otherwise provided by the Administrator at any
          time, the death of an optionee during a period provided in this
          Section 5(a)(viii) for the exercise of a Stock Option shall extend
          such period for 12 months from the date of death, subject to
          termination on the expiration of the stated term of the Option, if
          earlier.

          (ix) TERMINATION FOR CAUSE. If any optionee's employment by (or
     business relationship with) the Company and its Subsidiaries is terminated
     for Cause, any Stock Option held by such optionee, including any Stock
     Option that is immediately exercisable at the time of such termination,
     shall immediately terminate and be of no further force and effect;
     provided, however, that the Administrator may, in its sole discretion,
     provide that such Stock Option can be exercised for a period of up to 30
     days from the date of termination of employment (or business relationship)
     or until the expiration of the stated term of the Option, if earlier.

          (x) OTHER TERMINATION. Unless otherwise determined by the
     Administrator, if an optionee's employment by (or business relationship
     with) the Company and its Subsidiaries terminates for any reason other than
     death, Disability, Retirement, or for Cause, any Stock Option held by such
     optionee may thereafter be exercised, to the extent it was exercisable on
     the date of termination of employment (or business relationship), for three
     months (or such longer period as the Administrator shall specify at any
     time) from the date of termination of employment (or business relationship)
     or until the expiration of the stated term of the Option, if earlier.

                                       9
<PAGE>

          (xi) ANNUAL LIMIT ON INCENTIVE STOCK OPTIONS. To the extent required
     for "incentive stock option" treatment under Section 422 of the Code, the
     aggregate Fair Market Value (determined as of the time of grant) of the
     shares of Stock with respect to which Incentive Stock Options granted
     under this Plan and any other plan of the Company or its parent and
     subsidiary corporations become exercisable for the first time by an
     optionee during any calendar year shall not exceed $100,000. To the extent
     that any Stock Option exceeds this limit, it shall constitute a
     Non-Qualified Stock Option.

     (b) RELOAD OPTIONS. At the discretion of the Administrator, Options granted
under Section 5(a) may include a "reload" feature pursuant to which an optionee
exercising an option by the delivery of a number of shares of Stock in
accordance with Section 5(a)(v)(B) hereof would automatically be granted an
additional Option (with an exercise price equal to the Fair Market Value of the
Stock on the date the additional Option is granted and with the same expiration
date as the original Option being exercised, and with such other terms as the
Administrator may provide) to purchase that number of shares of Stock equal to
the number delivered to exercise the original Option.

     (c) NON-TRANSFERABILITY OF OPTIONS. No Stock Option shall be transferable
by the optionee otherwise than by will or by the laws of descent and
distribution and all Stock Options shall be exercisable, during the optionee's
lifetime, only by the optionee. Notwithstanding the foregoing, the Administrator
may provide in an option agreement evidencing a Non-Qualified Stock Option that
the optionee may transfer, without consideration for the transfer, such
Non-Qualified Stock Option to members of his immediate family, to trusts for the
benefit of such family members, to partnerships in which such family members are
the only partners, or to charitable organizations, provided that the transferee
agrees in writing with the Company to be bound by all of the terms and
conditions of the Plan and the applicable option agreement.

     (d) FORM OF SETTLEMENT. Shares of Stock issued upon exercise of a Stock
Option shall be free of all restrictions under the Plan, except as otherwise
provide in the Plan.

SECTION 6. STOCK APPRECIATION RIGHTS.
           -------------------------

     (a) NATURE OF STOCK APPRECIATION RIGHTS. A Stock Appreciation Right is an
Award entitling the recipient to receive an amount in cash or shares of Stock or
a combination thereof having a value equal to the excess of the Fair Market
Value of the Stock on the date of exercise over the exercise price per Stock
Appreciation Right set by the Administrator at the time of grant, which price
shall not be less than 85% of the Fair Market Value of the Stock on the date of
grant (or over the option exercise price per share, if the Stock Appreciation
Right was granted in tandem with a Stock Option) multiplied by the number of
shares of Stock with respect to which the Stock Appreciation Right shall have
been exercised, with the Administrator having the right to determine the form of
payment.

                                       10
<PAGE>

     (b) GRANT AND EXERCISE OF STOCK APPRECIATION RIGHTS. Stock Appreciation
Rights may be granted by the Administrator in tandem with, or independently of,
any Stock Option granted pursuant to Section 5 of the Plan. In the case of a
Stock Appreciation Right granted in tandem with a Non-Qualified Stock Option,
such Stock Appreciation Right may be granted either at or after the time of thc
grant of such Option. In the case of a Stock Appreciation Right granted in
tandem with an Incentive Stock Option, such Stock Appreciation Right may be
granted only at the time of the grant of the Option.

     A Stock Appreciation Right or applicable portion thereof granted in tandem
with a Stock Option shall terminate and no longer be exercisable upon the
termination or exercise of the related Option.

     (c) TERMS AND CONDITIONS OF STOCK APPRECIATION RIGHTS. Stock Appreciation
Rights shall be subject to such terms and conditions as shall be determined from
time to time by the Administrator, subject to the following:

          (i) Stock Appreciation Rights granted in tandem with Options shall be
     exercisable at such time or times and to the extent that the related Stock
     Options shall be exercisable.

          (ii) Upon exercise of a Stock Appreciation Right, the applicable
     portion of any related Option shall be surrendered.

          (iii) Stock Appreciation Rights granted in tandem with an Option shall
     be transferable only when and to the extent that the underlying Option
     would be transferable. Stock Appreciation Rights not granted in tandem with
     a Option shall not be transferable otherwise than by will or the laws of
     descent or distribution. All Stock Appreciation Rights shall be exercisable
     during the participant's lifetime only by the participant or the
     participant's legal representative.

SECTION 7. RESTRICTED STOCK AWARDS
           -----------------------

     (a) NATURE OF RESTRICTED STOCK AWARDS. A Restricted Stock Award is an Award
entitling the recipient to acquire, at par value or such other purchase price
determined by the Administrator, shares of Stock subject to such restrictions
and conditions as the Administrator may determine at the time of grant
("Restricted Stock"). Conditions may be based on continuing employment (or other
business relationship) and/or achievement of pre-established performance goals
and objectives.

     (b) RIGHTS AS A STOCKHOLDER. Upon execution of a written instrument setting
forth the Restricted Stock Award and paying any applicable purchase price, a
participant shall have the rights of a stockholder with respect to the voting of
the Restricted Stock, subject to such conditions contained in the written
instrument evidencing the Restricted Stock Award. Unless the Administrator shall
otherwise determine, certificates evidencing

                                       11
<PAGE>

the Restricted Stock shall indicate when the stock is vested as provided in
Section 7(d) below.

     (c) RESTRICTIONS. Restricted Stock may not be sold, assigned, transferred,
pledged or otherwise encumbered or disposed of except as specifically provided
herein or in the written instrument evidencing the Restricted Stock Award. If a
participant's employment (or other business relationship) with the Company and
its Subsidiaries terminates for any reason, the Company shall have the right to
repurchase Restricted Stock with respect to which conditions have not lapsed at
their purchase from the participant or the participant's legal representative.

     (d) VESTING OF RESTRICTED STOCK. The Administrator at the time of grant
shall specify the dates or dates and/or the attainment of pre-established
performance goals, objectives and other conditions on which the
non-transferability of the Restricted Stock and the Company's right of
repurchase or forfeiture shall lapse. Subsequent to such date or dates and/or
the attainment of such pre-established performance goals, objectives and other
conditions, the shares on which all restrictions have lapsed shall no longer be
Restricted Stock and shall be deemed "vested." Except as may otherwise be
provided by the Administrator at any time, a participant's rights in any shares
of Restricted Stock that have not vested shall automatically terminate upon the
participant's termination of employment (or other business relationship) with
the Company and its Subsidiaries and such shares shall either be forfeited or
subject to the Company's right of repurchase as provided in Section 7(c) above.

     (e) WAIVER, DEFERRAL AND REINVESTMENT OF DIVIDENDS. The written instrument
evidencing the Restricted Stock Award may require or permit the immediate
payment, waiver, deferral or investment of dividends paid on the Restricted
Stock.

SECTION 8. UNRESTRICTED STOCK AWARDS.
           -------------------------

     (a) GRANT OR SALE OF UNRESTRICTED STOCK. The Administrator may, in its sole
discretion, grant (or sell at a purchase price determined by the Administrator)
an Unrestricted Stock Award to any participant, pursuant to which such
participant may receive shares of Stock free of any restrictions ("Unrestricted
Stock") under the Plan. Unrestricted Stock Awards may be granted or sold as
described in the preceding sentence in respect of past services or other valid
consideration, or in lieu of any cash compensation due to such participant.

     (b) ELECTIONS TO RECEIVE UNRESTRICTED STOCK IN LIEU OF COMPENSATION. Upon
the request of a participant and with the consent of the Administrator, each
participant may, pursuant to an advance written election delivered to the
Company no later than the date specified by the Administrator, receive a portion
of the cash compensation otherwise due to such participant in the form of shares
of Unrestricted Stock (valued at Fair Market Value

                                       12
<PAGE>

on the date or dates the cash compensation would otherwise be paid) either
currently or on a deferred basis.

     (e) RESTRICTIONS ON TRANSFERS. The right to receive shares of Unrestricted
Stock on a deferred basis may not be sold, assigned, transferred, pledged or
otherwise encumbered, other than by will or the laws of descent and
distribution.

SECTION 9. PERFORMANCE SHARE AWARDS
           ------------------------

     (a) NATURE OF PERFORMANCE SHARE AWARDS. A Performance Share Award is an
Award entitling the recipient to acquire shares of Stock upon the attainment of
specified performance goals. The Administrator may make Performance Share Awards
independent of or in connection with the granting of any other Award under the
Plan. The Administrator in its sole discretion shall determine whether and to
whom Performance Share Awards shall be made, the performance goals applicable
under each such Award, the periods during which performance is to be measured,
and all other limitations and conditions applicable to the awarded Performance
Shares; provided, however, that the Administrator may rely on the performance
goals and other standards applicable to other performance unit plans of the
Company in setting the standards for Performance Share Awards under the Plan.

     (b) RESTRICTIONS ON TRANSFER. Performance Share Awards. and all rights with
respect to such Awards may not be sold, assigned, transferred, pledged or
otherwise encumbered

     (c) RIGHTS AS A SHAREHOLDER. A participant receiving a Performance Share
Award shall have the rights of a shareholder only as to shares actually received
by the participant under the Plan and not with respect to shares subject to the
Award but not actually received by the participant. A participant shall be
entitled to receive a stock certificate evidencing the acquisition of shares of
Stock under a Performance Share Award only upon satisfaction of all conditions
specified in the written instrument evidencing the Performance Share Award (or
in a performance plan adopted by the Administrator).

     (d) TERMINATION. Except as may otherwise be provided by the Administrator
at any time prior to termination of employment (or other business relationship),
a participant's rights in all Performance Share Awards shall automatically
terminate upon the participant's termination of employment (or business
relationship) with the Company and its Subsidiaries for any reason.

     (e) ACCELERATION, WAIVER, ETC. At any time prior to the participant's
termination of employment (or other business relationship) by the Company and
its Subsidiaries, the Administrator may in its sole discretion accelerate, waive
or, subject to Section 13, amend any or all of the goals, restrictions or
conditions imposed under any Performance Share Award.

                                       13
<PAGE>

SECTION 10. DIVIDEND EQUIVALENT RIGHTS
            --------------------------

     (a) DIVIDEND EQUIVALENT RIGHTS. A Dividend Equivalent Right is an Award
entitling the recipient to receive credits based on cash dividends that would be
paid on the shares of Stock specified in the Dividend Equivalent Right (or other
award to which it relates) if such shares were held by the recipient. A Dividend
Equivalent Right may be granted hereunder to any participant, as a component of
another Award or as a freestanding award. The terms and conditions of Dividend
Equivalent Rights shall be specified in the grant. Dividend equivalents credited
to the holder of a Dividend Equivalent Right may be paid currently or may be
deemed to be reinvested in additional shares of Stock, which may thereafter
accrue additional equivalents. Any such reinvestment shall be at Fair Market
Value on the date of reinvestment or such other price as may then apply under a
dividend reinvestment plan sponsored by the Company, if any. Dividend Equivalent
Rights may be settled in cash or shares of Stock or a combination thereof, in a
single installment or installments. A Dividend Equivalent Right granted as a
component of another Award may provide that such Dividend Equivalent Right shall
be settled upon exercise, settlement, or payment of, or lapse of restrictions
on, such other award, and that such Dividend Equivalent Right shall expire or be
forfeited or annulled under the same conditions as such other award. A Dividend
Equivalent Right granted as a component of another Award may also contain terms
and conditions different from such other award.

     (b) INTEREST EQUIVALENTS. Any Award under this Plan that is settled in
whole or in part in cash on a deferred basis may provide in the grant for
interest equivalents to be credited with respect to such cash payment. Interest
equivalents may be compounded and shall be paid upon such terms and conditions
as may be specified by the grant.

SECTION 11. TAX WITHHOLDING
            ---------------

         (a) PAYMENT BY PARTICIPANT. Each participant shall, no later than the
date as of which the value of an Award or of any Stock or other amounts received
thereunder first becomes includable in the gross income of the participant for
Federal income tax purposes, pay to the Company, or make arrangements
satisfaction to the Administrator regarding payment of, any Federal, state, or
local taxes of any kind required by law to be withheld with respect to such
income. The Company and its Subsidiaries shall, to the extent permitted by law,
have the right to deduct any such taxes from any payment of any kind otherwise
due to the participant.

(b) PAYMENT IN STOCK. Subject to approval by the Administrator, a participant
may elect to have such tax withholding obligation satisfied, in whole or in
part, by (i) authorizing the Company to withhold from shares of Stock to be
issued pursuant to any Award a number of shares with an aggregate Fair Market
Value (as of the date the withholding is effected) that would satisfy the
withholding amount due; or (ii) transferring to the Company shares of Stock
owned by the participant with an aggregate Fair Market

                                       14
<PAGE>

Value (as of the date the withholding is effected) that would satisfy the
withholding amount due.

SECTION 12. TRANSFER. LEAVE OF ABSENCE. ETC
            -------------------------------

     For purposes of the Plan, the following events shall not be deemed a
termination of employment:

     (a) a transfer to the employment of the Company from a Subsidiary or from
the Company to a Subsidiary, or from one Subsidiary to another; or

     (b) an approved leave of absence for military service or sickness, or for
any other purpose approved by the Company, if the employee's right to
reemployment is guaranteed either by a statute or by contract or under the
policy pursuant to which the leave of absence was granted or if the
Administrator otherwise so provides in writing.

SECTION 13. AMENDMENTS AND TERMINATION
            --------------------------

     The Board may, at any time, amend or discontinue the Plan and the
Administrator may, at any time, amend or cancel any outstanding Award (or
provide substitute Awards at the same or reduced exercise or purchase price or
with no exercise or purchase price in a manner not inconsistent with the terms
of the Plan), but such price, if any, must satisfy the requirements which would
apply to the substitute or amended Award if it were then initially granted under
this Plan) for the purpose of satisfying changes in law or for any other lawful
purpose, but no such action shall adversely affect rights under any outstanding
Award without the holder's consent. If and to the extent determined by the
Administrator to be required by the Act to ensure that Incentive Stock Options
granted under the Plan are qualified under Section 422 of the Code, Plan
amendments shall be subject to approval by the Company stockholders entitled to
vote at a meeting of stockholders.

SECTION 14. STATUS OF PLAN
            --------------

     With respect to the portion of any Award which has not been exercised and
any payments in cash, Stock or other consideration not received by a
participant, a participant shall have no rights greater than those of a general
creditor of the Company unless the Administrator shall otherwise expressly
determine in connection with any Award or Awards. In its sole discretion, the
Administrator may authorize the creation of trusts or other arrangements to meet
the Company's obligations to deliver Stock or make payments with respect to
Awards hereunder, provided that the existence of such trusts or other
arrangements is consistent with the foregoing sentence.

SECTION 15. CHANGE OF CONTROL PROVISIONS
            ----------------------------

     Upon the occurrence of a Change of Control as defined in this Section 15:

                                       15
<PAGE>

     (a) Each outstanding Stock Option and Stock Appreciation Right shall
automatically become fully exercisable notwithstanding any provision to the
contrary herein.

     (b). Each Restricted Stock Award and Performance Share Award shall be
subject to such terms, if any, with respect to a Change of Control as have been
provided by the Administrator in connection with such Award.

     (c) "CHANGE OF CONTROL" shall mean the occurrence of any one of the
following events:

          (i) any "PERSON," as such term is used in Sections 13(d) and 14(d) of
     the Act (other than the Company, any of its Subsidiaries, or any trustee,
     fiduciary or other person or entity holding securities under any employee
     benefit plan or trust of the Company or any of its Subsidiaries), together
     with all "affiliates" and "associates" (as such terms are defined in Rule
     12b-2 under the Act) of such person, shall become the "beneficial owner"
     (as such term is defined in Rule 13d-3 under the Act), directly or
     indirectly, of securities of the Company representing in excess of 50% of
     either (A) the combined voting power of the Company's then outstanding
     securities having the right to vote in an election of the Company's Board
     of Directors ("Voting Securities") or (B) the then outstanding shares of
     Stock of the Company (in either such case other than as a result of an
     acquisition of securities directly from the Company); or

          (ii) persons who, as of the Effective Date, constitute the Company's
     Board of Directors (the "Incumbent Directors") cease for any reason,
     including, without limitation, as a result of a tender offer, proxy
     contest, merger or similar transaction, to constitute at least a majority
     of the Board, provided that any person becoming a director of the Company
     subsequent to the Effective Date whose election or nomination for election
     was approved by a vote of at least a majority of the Incumbent Directors
     shall, for purposes of this Plan, be considered an Incumbent Director; or

          (iii) the stockholders of the Company shall approve (A) any
     consolidation or merger of the Company or any Subsidiary where the
     shareholders of the Company, immediately prior to the consolidation or
     merger, would not, immediately after the consolidation or merger,
     beneficially own (as such term is defined in Rule 13d-3 under the Act),
     directly or indirectly, shares representing in the aggregate 80% or more of
     the voting shares of the corporation issuing cash or securities in the
     consolidation or merger (or of its ultimate parent corporation, if any),
     (B) any sale, lease, exchange or other transfer (in one transaction or a
     series of transactions contemplated or arranged by any party as a single
     plan) of all or substantially all of the assets of the Company or (C) any
     plan or proposal for the liquidation or dissolution of the Company.

                                       16
<PAGE>

     Notwithstanding the foregoing, a "Change of Control" shall not be deemed to
have occurred for purposes of the foregoing clause (i) solely as the result of
an acquisition of securities by the Company which, by reducing the number of
shares of Stock or other Voting Securities outstanding, increases (x) the
proportionate number of shares of Stock beneficially owned by any person in
excess of 50% or more of the shares of Stock then outstanding or (y) the
proportionate voting power represented by the Voting Securities beneficially
owned by any person in excess of 50% or more of the combined voting power of all
then outstanding Voting Securities; PROVIDED, HOWEVER, that if any person
referred to in clause (x) or (y) of this sentence shall thereafter become the
beneficial owner of any additional shares of Stock or other Voting Securities
(other than pursuant to a stock split, stock dividend, or similar transaction),
then a "CHANGE OF CONTROL" shall be deemed to have occurred for purposes of the
foregoing clause (i).

SECTION 16. GENERAL PROVISIONS
            ------------------

     (a) NO DISTRIBUTION; COMPLIANCE WITH LEGAL REQUIREMENTS. The Administrator
may require each person acquiring Stock pursuant to an Award to represent to and
agree with the Company in writing that such person is acquiring the shares
without a view to distribution thereof.

     No shares of Stock shall be issued pursuant to an Award until all
applicable securities law and other legal and stock exchange or similar
requirements have been satisfied. The Administrator may require the placing of
such stop-orders and restrictive legends on certificates for Stock and Awards as
it deems appropriate.

     (b) DELIVERY OF STOCK CERTIFICATES. Delivery of stock certificates to
participants under this Plan shall be deemed effected for all purposes when the
Company or a stock transfer agent of the Company shall have mailed such
certificates in the United States mail, addressed to the participant, at the
participant's last known address on file with the Company.

     (c) OTHER COMPENSATION ARRANGEMENTS: NO EMPLOYMENT RIGHTS. Nothing
contained in this Plan shall prevent the Board from adopting other or additional
compensation arrangements, including trusts, and such arrangements may be either
generally applicable or applicable only in specific cases. The adoption of this
Plan and the grant of Awards do not confer upon any employee any right to
continued employment with the Company or any Subsidiary.

SECTION 17. EFFECTIVE DATE OF PLAN
            ----------------------

     This Plan shall become effective upon approval by the holders of a majority
of the shares of Stock of the Company present or represented and entitled to
vote at a meeting of stockholders. Subject to such approval by the stockholders
and to the requirement that no Stock may be issued hereunder prior to such
approval, Stock Options and other Awards may be granted hereunder on and after
adoption of this Plan by the Board.

                                       17
<PAGE>

SECTION 18. GOVERNING LAW
            -------------

     This Plan shall be governed by Delaware law, except to the extent such law
is preempted by federal law.

DATE APPROVED BY BOARD OF DIRECTORS: March 7, 2000

DATE APPROVED BY STOCKHOLDERS: May 9, 2000

                                       18

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