Document:

EX-10.42.4

 

    Exhibit 10.42.4

    [DURECT
    LETTERHEAD]

 

    January 20,
    2006

 

    BY FACSIMILE AND EXPRESS MAIL
CONFIDENTIAL

 

Peter A. Lankau

President and CEO

Endo Pharmaceuticals Inc.

100 Endo Boulevard

Chadds Ford PA 19317

 

	 	Re:	 	Amendment 3 to Development,
    Commercialization and Supply License Agreement

 

    Dear Peter:

 

    Reference is made to the Development, Commercialization and
    Supply License Agreement between Endo Pharmaceuticals Inc.
    (“Endo”) and DURECT Corporation (“DURECT”)
    effective November 8, 2002, as last amended
    November 22, 2004 (the “Agreement”). Effective on
    the date written above, Endo and DURECT hereby agree to amend
    the Agreement as follows:

 

	 	1.	 	Amendment to Section 4.6(a). Section 4.6(a) of the
Agreement shall be amended to replace each instance of “January
1, 2006” with “May 1, 2007”.

 

	 	2.	 	Amendment to Section 4.6(c). Section 4.6(c) of
    the Agreement shall be replaced in its entirety to read as
    follows:

 

	 	 	 	Notwithstanding anything to the contrary in Sections 4.6(a)
    and (b) and except as set forth in this
    Section 4.6(c), Endo shall have no obligations under
    Sections 4.6(a) and (b) to make any payments to DURECT
    for any Developments Costs incurred up to and including the date
    sixty (60) days following the delivery to Endo of written
    notice that a human pharmacokinetic trial has been completed
    with the Product together with a full study report of the
    results of such trial (such date, the “Trial Results Review
    Date”, such notice, the “Trial Completion Notice”
    and such trial, the “First Trial”). Notwithstanding
    the foregoing, in the event Endo has not delivered notice of its
    intent to terminate this Agreement pursuant to
    Section 13.3(e), then Endo shall be responsible for such
    portion of the Development Costs incurred after May 1, 2007
    in accordance with Section 4.6(a). Furthermore, until the
    Trial Results Review Date, DURECT hereby agrees to initiate any
    human trial only if such trial and the initiation thereof is
    consistent with a reasonable pharmaceutical company’s
    overall global strategic development plan for a product
    similarly situated to the Product. Finally, in no event shall
    Endo be liable for any costs associated with any human
    pharmacokinetic (PK) study undertaken by DURECT prior to the
    earlier of the Trial Results Review Date or March 31,
    2007.”

 

	 	3.	 	Amendment to Section 13.3(e). Section 13.3(e)
    of the Agreement shall be replaced in its entirety to read as
    follows:

    In the event that (i) the Trial Results Review Date shall
    not have occurred on or before March 31, 2007, or
    (ii) Endo determines, in its sole discretion, to terminate
    the Agreement during the sixty-day period beginning on the Trial
    Results Review Date, Endo shall have the right to terminate this
    Agreement effective upon 10 days’ written notice with
    no further rights or obligations hereunder (other than those
    rights or obligations which are expressly indicated herein to
    survive termination or expiration of this Agreement); provided
    that such written notice is delivered to DURECT no later than
    April 30, 2007.

 

	 	4.	 	The term “Trial Results Review Date” shall be
    substituted in lieu of “Trial Commencement Date”
    throughout the Agreement.

 

    Except as set forth above, all other terms of the Agreement
    shall remain the same. Please sign below to indicate Endo’s
    agreement to the foregoing.

 

	 	Very truly yours,

/s/ JAMES E. BROWN              

James E. Brown

President and CEO

 

AGREED TO BY ENDO:

 

	BY:	 	/s/ PETER A. LANKAU  
 
 
 
 
 
 

Peter A. Lankau

President and CEO

Date:    1/23/06<PAGE>
                                                                   EXHIBIT 10.20

                  GENERAL FORM OF SPECIAL RETENTION AGREEMENT
                  -------------------------------------------

                                                                          [Date]

<<Firstname>> <<Lastname>>,
American International Building
29 Richmond Road,
Pembroke HM 08
Bermuda

                         RE: SPECIAL RETENTION AGREEMENT

Dear <<Firstname>>:

          The Company desires to provide you with a special incentive to remain
employed with the Group through January 31, 2007 (the "Retention Period"). We
set forth below the terms of your Special Retention Agreement with IPCRe
Limited, a Bermuda company (the "Company"), referred to together with its
affiliates as the "Group".

1.   YOUR COMPENSATION

               (a) Salary. Your annual salary will be increased from __________
     to __________, effective January 1, 2006 and will be paid in accordance
     with the Group's normal practices.

               (b) Bonus. You will continue to be eligible to receive an annual
     cash bonus (your "Bonus") for each fiscal year of the Company under the
     terms of the Group's regular bonus program.

                (c) Special Retention Bonus. You will receive a special bonus of
      _________ (your "Retention Award"), which will be in addition to any other
      compensation paid to you for your services if you are an employee in good
      standing of the Group on January 31, 2007. If your employment with the
      Group is terminated after January 1, 2006 and before January 31, 2007 as a
      result of your death or "Disability" (as defined below) or "Retirement"
      (as defined below), or the Company terminates your employment without
      "Cause" <<Reten_Bon06>> (as defined below), the Company will pay to you
      (or, in the event of your death, your estate) the Retention Award.

<PAGE>

                                                                             -2-

2.   TERMINATION OF YOUR EMPLOYMENT WITH THE GROUP.

               (a) No Reason Required. You or the Company may terminate your
     employment at any time for any reason, or for no reason, subject to
     compliance with Section 2(b). This includes termination by the Company with
     or without Cause.

               (b) Advance Notice Required. To terminate your employment during
     the Retention Period, either you or the Company must provide notice to the
     other (a "Termination Notice"). You and the Company agree to provide 180
     days' advance Termination Notice of any termination, unless your employment
     is terminated by the Company for Cause or because of your Disability or
     death. The Company may elect to direct at any time during your employment
     that you work from your home and may require that you perform no duties. If
     either party shall give notice under this clause, you agree that you will
     immediately (i) resign from any office or directorship that you hold with
     the company or the Group and (ii) return all property of the Group in your
     possession. During any notice period your salary and benefits will continue
     save that you will not be eligible for Bonus. Your eligibility for Bonus
     for the period prior to the date of notice shall not change. The Company
     may in its absolute discretion pay you in lieu of notice for all or a part
     of the notice period.

               (c) Termination Date. The effective date of termination of your
     employment will be:

               (1) 180 days after Termination Notice is given, unless your
          employment is terminated by the Company for Cause or by your
          Disability or death,

               (2) the time Termination Notice is given, if your employment is
          terminated by the Company for Cause, although the Company may provide
          a later effective date in the Termination Notice,

               (3) 30 days after Termination Notice is given, if your employment
          is terminated because of your Disability, or

               (4) the time of your death, if your employment is terminated
          because of your death.

               (d) Termination by the Company for Cause.

               (1) "Cause" means any of the following:

                    (A) Your continued and willful failure to perform
               substantially your responsibilities to the Group, after demand
               for substantial performance has been given by any officer of the
               Group to whom you report that specifically identifies how you
               have not substantially performed your responsibilities.

<PAGE>

                                                                             -3-

                    (B) Your willful engagement in illegal conduct or in gross
               misconduct.

                    (C) Your commission or conviction of, or plea of guilty or
               nolo contendere to, a felony.

                    (D) Your intentional or grossly negligent disclosure of
               proprietary information or your failure to abide by the terms of
               Annex B of this Agreement.

               (e) Termination on Disability, or Retirement.

               (1) The term "Disability" has the same meaning as under the
          Company's Group Long Term Disability insurance coverage. If the
          Company determines in good faith that your Disability has occurred, it
          may give you Termination Notice. If within 30 days of the Termination
          Notice you do not return to full-time performance of your
          responsibilities, your employment will terminate. If you do return to
          full-time performance in that 30-day period, the Termination Notice
          will be cancelled for all purposes of this Agreement.

               (2) "Retirement" means your termination of employment on or after
          your 65th birthday or in the event you and the Company agree that you
          shall be eligible for early retirement.

               (f) Transition Assistance. During the 180 days after Termination
     Notice has been given, you will take all actions the Group may reasonably
     request to maintain for the Group the business, goodwill and business
     relationships with any Clients (as defined in Annex B).

3.   YOUR OBLIGATIONS TO THE GROUP IN REGARD TO PROPRIETARY INFORMATION.

          In addition to, and not in substitution for any existing obligations
that you have in respect of Proprietary Information of the Group, you agree to
abide by the provisions of Annex A.

4.   YOUR OBLIGATIONS TO THE GROUP IN CONNECTION WITH COMPETITIVE ACTIVITIES

          In addition to and not in substitution for any existing obligations
that you have in respect of not engaging in activities that are competitive with
the Group, you agree to abide by the terms of Annex B during the period of your
employment by the Group.

5.   EFFECT ON OTHER AGREEMENTS; ENTIRE AGREEMENT.

          This Agreement is the entire agreement between you and the Company,
and supersedes any earlier agreement, written or oral, with respect to the
subject matter of this Agreement. In entering into this Agreement, no party has
relied on or made any

<PAGE>

                                                                             -4-

representation, warranty, inducement, promise or understanding that is not in
this Agreement.

6.   SUCCESSORS.

               (a) Assignment by You. You may not assign this Agreement without
     the Company's consent. Also, except as required by law, your right to
     receive payments or benefits under this Agreement may not be subject to
     execution, attachment, levy or similar process. Any attempt to effect any
     of the preceding in violation of this Section 6(a), whether voluntary or
     involuntary, will be void. This Agreement shall inure to the benefit of and
     be enforceable by your legal representatives.

               (b) Successors to the Company. This Agreement shall inure to the
     benefit of and be binding upon the Company and its successors and assigns.

7.   GENERAL PROVISIONS.

               (a) GOVERNING LAW. THIS AGREEMENT WILL BE GOVERNED BY AND
     CONSTRUED IN ACCORDANCE WITH THE LAW OF BERMUDA APPLICABLE TO CONTRACTS
     MADE AND TO BE PERFORMED ENTIRELY WITHIN BERMUDA.

               (b) Withholding. You and the Group will treat all payments to you
     under this Agreement as compensation for services. Accordingly, the Group
     may withhold from any payment any taxes that are required to be withheld
     under any law, rule or regulation.

               (c) Severability. If any provision of this Agreement is found by
     any court of competent jurisdiction (or legally empowered agency) to be
     illegal, invalid or unenforceable for any reason, then (1) the provision
     will be amended automatically to the minimum extent necessary to cure the
     illegality or invalidity and permit enforcement and (2) the remainder of
     this Agreement will not be affected. In particular, if any provision of
     Section 4 is so found to violate law or be unenforceable because it applies
     for longer than a maximum permitted period or to greater than a maximum
     permitted area, it will be automatically amended to apply for the maximum
     permitted period and maximum permitted area.

               (d) Notices. All notices, requests, demands and other
     communications under this Agreement must be in writing and will be deemed
     given (1) on the business day sent, when delivered by hand or facsimile
     transmission (with confirmation) during normal business hours, (2) on the
     business day after the business day sent, if delivered by a nationally
     recognized overnight courier or (3) on the third business day after the
     business day sent if delivered by registered or certified mail, return
     receipt requested, in each case to the following address or number (or to
     such other addresses or numbers as may be specified by notice that conforms
     to this Section 7(d)):

<PAGE>

                                                                             -5-

          If to you, to the address stated in the Company's personnel records.

          If to the Company or any other member of the Group, to:

                    IPCRe Limited
                    American International Building
                    29 Richmond Road
                    Pembroke, HM, Bermuda
                    Attention: James P. Bryce
                    Facsimile: +1 441 292-8085

               (e) Amendments and Waivers. Any provision of this Agreement may
     be amended or waived but only if the amendment or waiver is in writing and
     signed, in the case of an amendment, by you and the Company or, in the case
     of a waiver, by the party that would have benefited from the provision
     waived. Except as this Agreement otherwise provides, no failure or delay by
     you or the Group to exercise any right or remedy under this Agreement will
     operate as a waiver, and no partial exercise of any right or remedy will
     preclude any further exercise.

               (f) Counterparts. This Agreement may be executed counterparts,
     each of which will constitute an original and all of which, when taken
     together, will constitute one agreement.

     Please confirm your acceptance of the terms of this Agreement by signing
where indicated below.

                                        Very truly yours,

                                        /s/ James Bryce
                                        ----------------------------------------
                                        James Bryce
                                        President & CEO

Accepted and Agreed this ____ day of _______________, 200__ :

                                        <<
-------------------------------------   ----------------------------------------
Signature                               Name:

<PAGE>

                                     ANNEX A

                             PROPRIETARY INFORMATION

     (a) Definition. "Proprietary Information" means confidential or proprietary
information, knowledge or data concerning (1) the Group's businesses,
strategies, operations, financial affairs, organizational matters, personnel
matters, budgets, business plans, marketing plans, studies, policies,
procedures, products, ideas, processes, software systems, trade secrets and
technical know-how, including the Group's underwriting and risk analysis
programs and modeling, (2) any other matter relating to the Group and (3) any
matter relating to clients of the Group or other third parties having
relationships with the Group. Proprietary Information includes (1) information
regarding any aspect of your tenure as an employee of the Group or the
termination of your employment, (2) the names, addresses, and phone numbers and
other information concerning clients and prospective clients of the Group
including underwriting information as to historical exposure and loss experience
and catastrophe modeling relating to clients and prospective clients of the
Group, (3) information and materials concerning the personal affairs of
employees of the Group. In addition, Proprietary Information may include
information furnished to you orally or in writing (whatever the form or storage
medium) or gathered by inspection, in each case before or after the date of this
Agreement. However, Proprietary Information does not include information (1)
that was or becomes generally available to you on a non-confidential basis, if
the source of this information was not reasonably known to you to be bound by a
duty of confidentiality, (2) that was or becomes generally available to the
public, other than as a result of a disclosure by you, directly or indirectly,
or (3) that you can establish was independently developed by you without
reference to any Proprietary Information.

     (b) Use and Disclosure. You have obtained or created Proprietary
Information in the course of your involvement in the Group's activities and may
continue to do so. You agree that the Proprietary Information is the exclusive
property of the Group, and you agree to use and disclose Proprietary Information
only for the Group's benefit and in accordance with any restrictions placed on
its use or disclosure by the Group. In addition, nothing in this Agreement will
operate to weaken or waive any rights the Group may have under statutory or
common law, or any other agreement, to the protection of trade secrets,
confidential business information and other confidential information.

     (c) Return of Proprietary Information. When your employment terminates, you
agree to return to the Company all Proprietary Information, including all notes,
mailing lists, rolodexes and computer files that contain any Proprietary
Information. You agree to do anything reasonably requested by the Company in
furtherance of perfecting the Group's possession of, and title to, any
Proprietary Information that was at any time in your possession.

<PAGE>

                                                                             -7-

                                     ANNEX B

                             COMPETITIVE ACTIVITIES

     (a) General Effect. This Annex B applies during your employment [and, in
respect of paragraph (e) below relating to the solicitation of Group employees,
one year after your termination of employment]. On termination of your
employment in accordance with Section 2 of the Special Retention Agreement, you
will have no further obligations to the Group under this Annex B [except as
provided in paragraph (e)]. However, this Annex B will not affect the Group's
rights under any other agreement with you, including under any plan. This Annex
B uses the following defined terms:

          "Competitive Enterprise" means any business enterprise that either (1)
     engages in any activity that competes anywhere with any activity that the
     Group is then engaged in or (2) holds a 5% or greater equity, voting or
     profit participation interest in any enterprise that engages in such a
     competitive activity.

          "Client" means any client or prospective client of the Group to whom
     you provided services, or for whom you transacted business, or whose
     identity became known to you in connection with your relationship with or
     employment by the Group.

          "Solicit" means any direct or indirect communication of any kind,
     regardless of who initiates it, that in any way invites, advises,
     encourages or requests any person to take or refrain from taking any
     action.

     (b) Your Importance to the Group and the Effect of this Section 4. You
acknowledge that in the course of your involvement in the Group's activities,
you will have access to Proprietary Information and the Group's client base and
will profit from the goodwill associated with the Group. On the other hand, in
view of your access to Proprietary Information and your importance to the Group,
if you compete with the Group, the Group will likely suffer significant harm. In
return for the benefits you will receive from the Group and in light of the
potential harm you could cause the Group, you agree to the provisions of this
Annex B.

     (c) Non-competition. Until the effective date of your termination of
employment with the Group, you will not directly or indirectly:

          (1) hold a 5% or greater equity, voting or profit participation
     interest in a Competitive Enterprise; or

          (2) associate (including as a director, officer, employee, partner,
     consultant, agent or advisor) with a Competitive Enterprise and in
     connection with your association engage, or directly or indirectly manage
     or supervise personnel engaged, in any activity:

<PAGE>

                                                                             -8-

               (A) that is substantially related to any activity that you were
          engaged in,

               (B) that is substantially related to any activity for which you
          had direct or indirect managerial or supervisory responsibility, or

               (C) that calls for the application of specialized knowledge or
          skills substantially related to those used by you in your activities.

     (d) Non-Solicitation of Clients. Until the effective date of your
termination of employment with the Group, you will not attempt to:

          (1) Solicit any Client to transact business with a Competitive
     Enterprise or to reduce or refrain from doing any business with the Group,

          (2) transact business with any Client that would cause you to be a
     Competitive Enterprise or to reduce or refrain from doing any business with
     the Group, or

          (3) interfere with or damage any relationship between the Group and a
     Client.

     (e) Non-Solicitation of Group Employees. Until the [first anniversary of
the] effective date of your termination of employment with the Group, you will
not attempt to Solicit anyone who is then an employee of the Group (or who was
an employee of the group within the prior six months) to resign from the Group
or to apply for or accept employment with any Competitive Enterprise.

<PAGE>

                                                                             -9-

                                    SCHEDULE

<TABLE>
<CAPTION>
                     Base Salary
                    As of 1/1/06   Retention Bonus
                    ------------   ---------------
<S>                 <C>            <C>
Peter J. Cozens       $424,000         $212,000
Stephen F. Fallon     $424,000         $212,000
John R. Weale         $366,100         $183,050
</TABLE>

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