Document:

<PAGE>

                                                                    EXHIBIT 10.8

                                    AGREEMENT

         THIS AGREEMENT ("Agreement"), effective March 3, 1995 ("Effective
Date"), is entered into by and between Stratagene, a California corporation
("Stratagene"), and Ronni L. Sherman ("Employee").

         WHEREAS, Stratagene recognizes the value of the services that Employee
has rendered to Stratagene and desires to be assured that Employee will continue
to provide services to Stratagene; and

         WHEREAS, Employee is willing to continue to provide services to
Stratagene subject to assurances that Employee shall continue to have her
present responsibility and status with Stratagene in the event of any change in
control of the company.

         NOW, THEREFORE, in consideration of the promises and mutual agreements
contained herein, Stratagene and Employee hereby agree as follows:

         1.       Termination Following Change in Control. In the event
Employee's employment is terminated in anticipation of or subsequent to a Change
in Control, Employee shall be entitled to the compensation and benefits set
forth in Section 2 unless such termination occurs as result of (i) Employee's
death, (ii)

                                        1

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termination of Employee by Stratagene for Cause, or (iii) termination of
employment by Employee other than for Good Reason.

         2.       Benefits Upon Termination. If Employee's employment by
Stratagene is terminated as set forth in Section 1, Employee shall be entitled
to the following compensation and benefits:

                  2.1      Employee shall receive Employee's full base salary
         through the Date of Termination at the salary level in effect at the
         time the Notice of Termination is given plus amounts for any vacation
         accrued but not taken and the amount, if any, of any bonuses which have
         accrued but have not been paid to Employee under any bonus plans;

                  2.2      In lieu of any further salary payments to Employee
         for periods subsequent to the Date of Termination, Stratagene shall pay
         as a severance payment to Employee within ten (10) days following the
         Date of Termination a lump sum amount equal to the product of
         Employee's annual base salary at the highest rate in effect during the
         twelve (12) months immediately preceding the Date of Termination
         multiplied by a number to be determined by Mr. Jean Deleage in his sole
         discretion and appended to this Agreement within thirty (30) days from
         the

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         Effective Date of this Agreement; provided, however, that such number
         shall be no less than 1.5 and no greater than 2.0.

                  2.3      Stratagene shall maintain in full force and effect,
         for Employee's continued benefit until the earlier of (i) two (2) years
         after the Date of Termination, or (ii) Employee's commencement of full
         time employment with a new employer, all health insurance, dental
         insurance, life insurance and disability plans, programs or
         arrangements in which Employee was entitled to participate immediately
         prior to the Date of Termination, provided that Employee's continued
         participation is possible under the general terms and provisions of
         such plans and programs. In the event that Employee's participation in
         any such plan or program is barred, Stratagene shall arrange to provide
         Employee with benefits substantially similar to those which Employee
         was otherwise entitled to receive under such plans and programs.

                  2.4      All of Employee's stock options issued under any
         Stratagene stock option plan, including Stratagene's phantom stock
         option plan, shall immediately vest and all options shall be
         immediately exercisable. Further, upon the election of Employee, in her
         sole discretion, Stratagene shall pay to Employee, in cash, an amount
         equal to the excess of the fair market value of all shares of
         Stratagene stock issuable upon

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         exercise of any outstanding stock options granted to Employee, over the
         aggregate exercise price, if any, of such stock options.

         3.       Notice of Termination. Any purported termination of Employee
by Stratagene for Cause or by Employee for Good Reason shall be communicated by
written Notice of Termination. For purposes of this Agreement, a "Notice of
Termination" shall mean a notice which shall set forth the termination provision
in this Agreement relied upon and reasonable detail of the facts and
circumstances claimed to provide a basis for termination of Employee's
employment.

         4.       Term of Agreement. The term of this Agreement shall commence
as of March 3, 1995, and shall continue for a period of three (3) years and any
extensions thereafter ("Term"). The initial term shall automatically be
extended for additional yearly periods without further action by the parties on
March 3, 1998 and on each succeeding March 3 thereafter, such that as of each
March 3, this Agreement shall have a remaining term of one (1) year. Either
party may, however, provide written notice of non-renewal ("Notice of
Non-Renewal") to the other party prior to March 3, 1998 or prior to March 3 of
any succeeding year, as the case may be, of such party's intention that this
Agreement shall expire at the end

                                        4

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of the Term that began with the March 3 preceding such Notice of
Non-Renewal.

         5.       Stratagene's Right to Terminate. Nothing in this Agreement
shall limit Stratagene's ability to terminate Employee's employment at any time,
subject to providing the compensation and benefits provided herein.

         6.       Mitigation. Employee shall not be required to mitigate the
amount of any payment provided for in this Agreement by seeking employment or
otherwise nor shall the amount of any payment provided for in this Agreement be
reduced by any compensation earned by Employee as a result of employment by
another employer after the Date of Termination.

         7.       Limitation on Payments.

                  Notwithstanding any other provision in this Agreement, in the
event that any severance payment by Stratagene to or for the benefit of
Employee, whether paid or payable pursuant to the terms of this Agreement or
otherwise, would be nondeductible by Stratagene for Federal income tax purposes
as a result of Section 280G of the Internal Revenue Code of 1986, as amended
(the "Code"), then the aggregate present value of the amounts payable to or for

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the benefit of Employee Pursuant to this Agreement shall be reduced to the
maximum amount that is deductible in accordance with Section 280G of the Code.

         8.       Definitions.

                  8.1      "Cause" shall mean termination of Employee by
         Stratagene upon:

                           (i) the willful and continued failure of Employee to
                  substantially perform Employee's duties for or on behalf of
                  Stratagene (other than any failure resulting from Employee's
                  incapacity due to physical or mental illness), after a demand
                  for substantial performance is delivered to Employee by the
                  Chief Executive Officer of Stratagene which specifically
                  identifies the manner in which it is believed that Employee
                  has not substantially performed her duties; or

                           (ii) the willful engaging by Employee in misconduct
                  which is materially injurious to Stratagene, monetarily or
                  otherwise. For purposes of this paragraph 8.1, no act, or
                  failure to act, on Employee's part shall be deemed "willful"
                  if such act or omission was in good faith or with a reasonable
                  belief by Employee that such act or omission was in the best
                  interests of Stratagene.

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                  8.2      "Change in Control" shall occur if:

                           (i) there shall be consummated any consolidation,
                  acquisition, merger or other reorganization of Stratagene (a)
                  in which Stratagene is not the continuing or surviving
                  corporation, or its shareholders as of the Effective Date are
                  not in control, (b) pursuant to which shares of Stratagene's
                  common stock would be converted into cash, securities or other
                  property, other than a merger of Stratagene in which the
                  holders of Stratagene's common stock immediately prior to the
                  merger have the same proportionate ownership of common stock
                  of the surviving corporation immediately after the merger, or
                  (c) after which the directors of Stratagene immediately before
                  the transaction shall cease to constitute a majority of the
                  Board of Directors of Stratagene or of any successor to
                  Stratagene;

                           (ii) there is a sale, lease, exchange or other
                  transfer (in one transaction or a series of related
                  transactions) of all, or substantially all, of the assets of
                  Stratagene;

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                           (iii) the stockholders of Stratagene approve any plan
                  or proposal for the liquidation or dissolution of Stratagene;

                           (iv) another person or entity acquires beneficial
                  ownership, directly or indirectly, of securities of Stratagene
                  representing twenty five percent (25%) or more of the combined
                  voting power of Stratagene's then outstanding securities in
                  one or more transaction;

                           (v) there is any change which has the actual or
                  potential effect of decreasing the current level of management
                  authority, or control of the Chief Executive Officer of
                  Stratagene in office on December 8, 1994; or

                           (vi) during any period of twenty-four (24)
                  consecutive months, commencing before or after the Effective
                  Date, Dr. Joseph A. Sorge, Jean Deleage and Ronni Sherman
                  cease for any reason to constitute at least a majority of the
                  Board of Directors of the Company, unless the election, or the
                  nomination for election, of each new director taking office
                  after December 8, 1994 has been approved by a vote of at least
                  two-thirds (2/3) of the directors in office prior to December
                  8, 1994.

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                  8.3      "Date of Termination" shall mean the date on which
         Notice of Termination is given.

                  8.4      "Good Reason" shall mean termination of employment by
         Employee based on:

                           (i)      The assignment by Stratagene of any duties
                  inconsistent with Employee's position, duties,
                  responsibilities and status within Stratagene immediately
                  prior to a Change in Control, or a change in Employee's
                  reporting responsibilities, status or titles in effect
                  immediately prior to a Change in Control, or any removal of
                  Employee from any such positions, except in connection with
                  the termination of Employee's employment as a result of
                  Employee's death or for Cause;

                           (ii)     A reduction by Stratagene in Employee's base
                  salary in effect as of the Effective Date;

                           (iii)    The failure of Stratagene to increase
                  Employee's base salary on January 1 of each year subsequent to
                  a Change in control by a percentage amount at least equal to
                  the average percentage increases given to Employee in the
                  three (3) years prior to a Change in Control;

                           (iv)     The failure by Stratagene to provide
                  Employee with any incentive or bonus compensation, stock

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                  options, stock awards and other employee benefits or plans at
                  levels not less than those applicable to comparable employees
                  of Stratagene immediately prior to a Change in Control, or to
                  provide their equivalents;

                           (v)      The requirement by stratagene that Employee
                  be based anywhere other than at Stratagene's executive offices
                  in La Jolla, California, except for required travel for
                  business to an extent substantially consistent with Employee's
                  present business travel obligations;

                           (vi)     The failure by Stratagene to obtain the
                  assumption to perform this Agreement by any successor in
                  interest as contemplated in Section 10.1;

                           (vii)    Any purported termination of Employee's
                  employment which is not effected pursuant to the Notice of
                  Termination in accordance with the requirements of Section 3,
                  which for purposes of this Agreement, shall not be effective;
                  or

                           (viii)   The failure by stratagene after a Change
                  in Control to continue in effect any benefit or compensation
                  plan, stock ownership plan, stock purchase plan, stock option
                  plan, health insurance plan, life insurance plan, or
                  disability plan in which Employee is participating at the time
                  of a Change in control of

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                  Stratagene (or plans providing Employee with substantially
                  similar benefits), the taking of any action by Stratagene
                  which would adversely affect Employee's participation in or
                  materially reduce Employee's benefits under any of such plans
                  or deprive Employee of any material fringe benefit enjoyed by
                  Employee at the time of the Change in Control, or the failure
                  by Stratagene to provide Employee with the number of paid
                  vacation days to which Employee is then entitled in accordance
                  with Stratagene's normal vacation policy in effect as of the
                  Effective Date.

         9.       Federal Income Tax Withholding. Stratagene may withhold from
any compensation or benefits payable under this Agreement all federal, state and
other withholding taxes required.

         10.      Miscellaneous.

                  10.1     Stratagene Successors. Stratagene will require any
         successor (whether direct or indirect, by purchase merger,
         consolidation or otherwise) to all or substantially all of the business
         and/or assets of Stratagene, by agreement to expressly assume and agree
         to perform this Agreement in the same manner and to the same extent
         that Stratagene would be

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         required to perform as if no such succession had taken place. Failure
         of Stratagene to obtain such an agreement prior to the effectiveness of
         any such succession shall be a breach of this Agreement and shall
         entitle Employee to compensation from Stratagene in the same amount and
         on the same terms as Employee would be entitled hereunder if Employee
         terminated Employee's employment for Good Reason, except that for
         purposes of implementing the foregoing, the date on which any such
         succession becomes effective shall be deemed the Date of Termination.

                  10.2     Successors. This Agreement shall inure to the benefit
         of and be enforceable by Employee's personal or legal representatives,
         executors, administrators, successors, heirs, distributees, devisees
         and legatees.

                  10.3     Notice. For purposes of this Agreement notices and
         all other communications provided for in the Agreement shall be in
         writing and shall be deemed to have been duly given when delivered or
         mailed by certified or registered mail, return receipt requested,
         postage prepaid, addressed to the respective addresses set forth below,
         or to such other address as either party may have furnished to the
         other in writing in

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<PAGE>

         accordance herewith, except that notice of change of address shall be
         effective only upon receipt.

         Stratagene:       Stratagene
                           11099 North Torrey Pines Road
                           La Jolla, CA 92037
                           Attention: Joseph A. Sorge
                           Chief Executive Officer

         Employee:         Ronni L. Sherman
                           [Intentionally Omitted]
                           [Intentionally Omitted]

                  10.4     Waiver. No provisions of this Agreement may be
         modified, waived or discharged unless such waiver, modification or
         discharge is agreed to in writing signed by Employee and Stratagene;
         provided, however, that this Agreement shall not supersede or in any
         way limit the rights, duties or obligations Employee may have under any
         other written agreement with Stratagene.

                  10.5     Severability. If, for any reason, any provision of
         this Agreement is held invalid, such invalidity shall not

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         affect any other provision of the Agreement not held so invalid and
         each such other provision shall, to the full extent consistent with
         law, continue in full force and effect.

         If any provision of this Agreement shall be held invalid in part, such
         invalidity shall in no way affect the rest of such provision not held
         so invalid, and the rest of such provision together with all other
         provisions of this Agreement shall, to the full extent consistent with
         law, continue in full force and effect.

                  10.6     Legal Fees. Stratagene shall pay to Employee all
         legal fees and expenses incurred by Employee as a result of any
         termination of employment as set forth in Section 1, including any fees
         and expenses, if any, incurred in contesting or disputing any such
         termination or in seeking to obtain or enforce any right or benefit
         provided by this Agreement.

                  10.7     Release. Employee hereby agrees that in the event of
         any termination of employment which results in the payments and
         benefits to Employee as set forth in this Agreement, Employee shall
         execute a mutually acceptable severance agreement and release with
         stratagene.

                                       14
<PAGE>

         IN WITNESS WHEREOF, Stratagene and Employee have executed this
Agreement as of the date first written above.

                                    STRATAGENE:

                                    By: /s/ JOSEPH A. SORGE
                                    --------------------------------------------

                                    EMPLOYEE:

                                    /s/ RONNI L. SHERMAN
                                    --------------------------------------------

                                       15<PAGE>

                                                                    EXHIBIT 10.9

                                 LOAN AGREEMENT

                                     between

                BASTROP COUNTY INDUSTRIAL DEVELOPMENT CORPORATION

                                       and

                             BIOCREST PARTNERS, L.P.

                                  ************

Bastrop County Industrial Development Corporation has granted a security
interest in and assigned to First Bank National Association, as Trustee under
the Indenture of Trust, dated as of the date hereof, all of its interests in all
"Loan Payments" due pursuant to and under this Loan Agreement to secure its
Variable Rate Demand Industrial Revenue Bonds (BioCrest Partners, L.P. Project),
Series 1997.

        DEBTOR:                                          LENDER:

BioCrest Partners, L.P.                    Bastrop County Industrial Development
c/o Wayne S. Hollingsworth                   Corporation
Strasburger & Price, L.L.P.                c/o County Judge's Office
2600 One American Center                   804 Pecan
Austin, Texas 78701                        Bastrop, Texas 78602

ASSIGNEE AND SECURED PARTY:

First Bank National Association
as Trustee
c/o First Trust of California, National Association
One California Street, 4th Floor
San Francisco, California 94111

<PAGE>

                               TABLE OF CONTENTS

<Table>
<S>                                                                          <C>
General Recitals and Findings ..............................................  1

                                   ARTICLE I
                                  Definitions

Section 1.01.   Definitions ................................................  2
Section 1.02.   Article and Section Headings ...............................  7
Section 1.03.   Interpretation .............................................  8

                                   ARTICLE II
                                Representations

Section 2.01.   Representations by Issuer ..................................  8
Section 2.02.   Representations by Company .................................  9

                                  ARTICLE III
                                  The Project

Section 3.01.   Approvals and Permits ...................................... 11
Section 3.02.   Acquisition and Construction ............................... 11
Section 3.03.   Construction Fund .......................................... 11
Section 3.04.   Completion Certificate ..................................... 12
Section 3.05.   Issuer's Limited Liability ................................. 13

                                   ARTICLE IV
                          Issuance of Bonds; The Loan

Section 4.01.   Issuance of Bonds .......................................... 13
Section 4.02.   The Loan ................................................... 13
Section 4.03.   Security for the Bonds ..................................... 13
Section 4.04.   Refunding of Bonds ......................................... 13

                                   ARTICLE V
                             The Company's Payments

Section 5.01.   Company Approval of Issuance of Bonds ...................... 14
Section 5.02.   Payment upon Redemption of Bonds ........................... 14
Section 5.03.   Loan Payments .............................................. 15
Section 5.04.   Payments to Issuer and Governmental Unit ................... 15
Section 5.05.   Issuer's Rights Assigned to Trustee ........................ 15
Section 5.06.   Payments to Trustee ........................................ 16
Section 5.07.   Payment to Remarketing Agent ............................... 16
Section 5.08.   Reserved for Future Use .................................... 16
</Table>
<PAGE>
<Table>
<Caption>

<S>                 <C>                                                                        <C>

Section 5.09.       Purchase of Bonds .......................................................  16
Section 5.10.       Usury ...................................................................  17
Section 5.11.       Letter of Credit ........................................................  17

                                   ARTICLE VI
                             Defaults and Remedies

Section 6.01.       Events of Default .......................................................  18
Section 6.02.       Remedies on Default .....................................................  19
Section 6.03.       Agreement to Pay Attorneys' Fees and Expenses ...........................  20

                                  ARTICLE VII
                               Special Covenants

Section 7.01.       No Defense or Set-Off, Unconditional Obligation .........................  21
Section 7.02.       Consolidation and Merger ................................................  21
Section 7.03.       Indemnities .............................................................  21
Section 7.04.       Tax-Exempt Status of the Bonds ..........................................  22
Section 7.05.       Payment to Rebate Fund ..................................................  25
Section 7.06.       Recordation .............................................................  25
Section 7.07.       Qualification in Texas ..................................................  25

                                  ARTICLE VIII
                               General Provisions

Section 8.01.       General Provisions ......................................................  25
Section 8.02.       Financial Statements ....................................................  26
Section 8.03.       Amendment of Agreement ..................................................  26
Section 8.04.       Assignment ..............................................................  27
Section 8.05.       Term of Agreement .......................................................  27
Section 8.06.       Notices .................................................................  27
Section 8.07.       Severability ............................................................  29
Section 8.08.       Execution of Counterparts ...............................................  29
Section 8.09.       Governing Law ...........................................................  29
Section 8.10.       No Personal Liability ...................................................  29
Section 8.11.       Final Agreement of the Parties ..........................................  29

Execution ...................................................................................  30

Exhibit A - Project Description .............................................................  A-1
Exhibit B - Disbursement Request ............................................................  B-1
</Table>

                                      iii

<PAGE>

                                 LOAN AGREEMENT

                                     between

                BASTROP COUNTY INDUSTRIAL DEVELOPMENT CORPORATION

                                       and

                             BIOCREST PARTNERS, L.P.

        This Loan Agreement dated as of April 1, 1997 (the "Agreement"), by and
between BASTROP COUNTY INDUSTRIAL DEVELOPMENT CORPORATION (the "Issuer") and
BIOCREST PARTNERS, L.P. (the "Company"):

                              W I T N E S S E T H:

                          GENERAL RECITALS AND FINDINGS

        (a) The Issuer is a non-stock, non-profit industrial development
corporation organized and existing under the laws of the State of Texas,
including particularly the Development Corporation Act of 1979, as amended,
Article 5190.6, Vernon's Annotated Texas Civil Statutes, as amended (the "Act"),
to act on behalf of Bastrop County, Texas (the "Governmental Unit") to provide
financing for certain "projects," as defined in the Act, located within the
boundaries of the Issuer; and

        (b) Pursuant to law, and particularly the Act, the Issuer is empowered
to make secured or unsecured loans to a user for the purpose of providing
temporary or permanent financing or refinancing of all or part of the costs of a
project, and to issue revenue bonds for such purpose and for the purpose of
refunding any such bonds; and

        (c) The Company is a limited partnership organized and existing under
the laws of the State of Delaware, and duly qualified to conduct business in the
State of Texas; and

        (d) The Company has requested that the Issuer issue its revenue bonds
for the purpose of making a loan of the proceeds of such bonds to the Company to
finance and refinance certain Project Costs (hereinafter defined) incurred by
the Company in the acquisition, construction, improvement and equipment of the
Project (hereinafter defined); and

        (e) The Issuer has determined that it is in the public interest to loan
the proceeds of its revenue bonds to the Company for such purpose in the manner
provided in the Act and this Agreement; and

        (f) The Company has agreed to make Loan Payments as provided hereunder;
and

        (g) The governing body of the Governmental Unit has approved this
Agreement by written resolution as required by the Act; and

<PAGE>

        (h) This Agreement is authorized and executed pursuant to applicable
laws, including the Act; and

        (i) The Issuer and the Company have taken all action and have complied
with all provisions of law with respect to the execution, delivery and
performance of this Agreement and the due authorization of the consummation of
the transactions contemplated hereby, and this Agreement has been duly executed
and delivered by, and constitutes a valid and legally binding agreement of, the
Issuer and the Company, enforceable against the respective parties in accordance
with its terms.

        NOW, THEREFORE, in consideration of the covenants and agreements herein
made, and subject to the conditions herein set forth, the Issuer and the Company
contract and agree as follows:

                                    ARTICLE I

                                   DEFINITIONS

        Section 1.01. DEFINITIONS. Each of the following terms shall have the
meaning assigned to them in this Section 1.01 whenever they are used in this
Agreement, unless the context in which they are used clearly requires otherwise:

        Act - shall mean the Development Corporation Act of 1979, as amended,
Article 5190.6, Vernon's Annotated Texas Civil Statutes, as amended.

        Act of Bankruptcy - shall mean any of the following events:

             (a) the Company shall (i) apply for or consent to the appointment
        of, or the taking of possession by, a receiver, custodian, trustee,
        liquidator or the like of the Company or of all or any substantial part
        of its property, (ii) commence a voluntary case under the United States
        Bankruptcy Code (as now or hereafter in effect), or (iii) file a
        petition seeking to take advantage of any other law relating to
        bankruptcy, insolvency, winding-up or composition or adjustment of
        debts; or

             (b) a proceeding or case shall be commenced without the application
        or consent of the Company in any court of competent jurisdiction,
        seeking (i) the liquidation, reorganization, dissolution, winding-up, or
        composition or adjustment of debts, of the Company, (ii) the appointment
        of a trustee, receiver, custodian, liquidator or the like of the Company
        or of all or any substantial part of its respective property, or (iii)
        similar relief in respect of the Company under any law relating to
        bankruptcy, insolvency, winding-up or composition or adjustment of debts
        and such proceeding or case is not dismissed within 90 days after
        commencement.

        Agreement - shall mean this Loan Agreement, dated as of April 1, 1997,
by and between the Issuer and the Company, including all amendments thereof or
supplements thereto.

                                       2
<PAGE>

        Alternate Credit Facility - shall mean any letter of credit or other
credit enhancement or support facility delivered to the Trustee pursuant to
Section 4.13 of the Indenture.

        Authorized Company Representative - shall mean such person at the time
and from time to time designated by written certificate furnished to the Issuer,
the Credit Facility Issuer and the Trustee containing the specimen signature of
such person and signed on behalf of the Company by the president, any vice
president, treasurer, assistant treasurer or other authorized person of the
Company to act on behalf of the Company. Such certificate may designate an
alternate or alternates.

        Authorized Governmental Unit Representative - shall mean such person at
the time and from time to time designated by written certificate furnished to
the Company, the Credit Facility Issuer and the Trustee containing the specimen
signature of such person and signed on behalf of the Governmental Unit by the
County Judge or County Clerk. Such certificate may designate an alternate or
alternates.

        Authorized Issuer Representative - shall mean such person at the time
and from time to time designated by written certificate furnished to the
Company, the Credit Facility Issuer and the Trustee containing the specimen
signature of such person and signed on behalf of the Issuer by its President or
Secretary. Such certificate may designate an alternate or alternates.

        Bank - shall mean Union Bank of California, N.A., a national banking
association, as issuer of the Letter of Credit.

        Board or Board of Directors - shall mean the lawfully qualified Board of
Directors of the Issuer.

        Bond Counsel - shall mean McCall, Parkhurst & Horton L.L.P. or such
other firm of attorneys of nationally recognized standing in the field of law
relating to municipal bond law and the exemption from federal income taxation of
interest on state or local bonds, selected by the Issuer and acceptable to the
Credit Facility Issuer and the Company.

        Bond Fund - shall mean the fund by that name established by Section 4.02
of the Indenture.

        Bond Owner, Bondowner, Owner, owner, Bondholder, bondholder, holder,
"Registered Owner;" "registered owner" or owner of the Bonds - when used with
respect to a Bond, shall mean the person or entity in whose name such Bond shall
be registered.

        Bond Purchase Fund - shall mean the fund by that name established by
Section 4.04 of the Indenture.

        Bond Resolution or Resolution - shall mean the Resolution of the Board
of Directors authorizing the issuance of the Bonds (including the Indenture
prescribed and authorized to be executed in the Bond Resolution) together with
any supplemental resolutions or amendments to the Resolution or such Indenture.

                                       3
<PAGE>
        Bonds - shall mean the Bastrop County Industrial Development Corporation
Variable Rate Demand Industrial Revenue Bonds (BioCrest Partners, L.P. Project),
Series 1997, executed and delivered pursuant to the Indenture.

        Business Day - shall mean any day on which commercial banks located in
all of the cities in which the Principal Offices of the Trustee, the Credit
Facility Issuer and the Remarketing Agent are located are not required or
authorized by law or regulation to remain closed and on which the New York Stock
Exchange is not closed.

        Code - shall mean the Internal Revenue Code of 1986, as amended, and the
rulings and regulations (including temporary and proposed regulations)
promulgated thereunder or, to the extent applicable, under the Internal Revenue
Code of 1954, as amended.

        Company - shall mean BioCrest Partners, L.P. and any successors and
assigns as permitted by Section 7.02 hereof together with any related persons
within the meaning of Section 144(a)(3) of the Code.

        Completion Certificate - shall mean the certificate of any Authorized
Company Representative stating that the acquisition and construction of the
Project has been completed or canceled and the date of such completion or
cancellation.

        Completion Date - shall mean the date specified as such in the
Completion Certificate.

        Construction Fund - shall mean the Fund by that name established by
Section 4.01 of the Indenture.

        Costs of Issuance - shall mean all costs and expenses incurred by the
Issuer or the Company in connection with the issuance and sale of the Bonds,
including without limitation (i) fees and reasonable expenses of accountants,
attorneys, engineers, financial advisors and the Placement Agent, (ii)
materials, supplies, and printing and engraving costs, (iii) recording and
filing fees, (iv) rating agency fees, and (v) the Issuer's and the Governmental
Unit's administrative expenses, if any, as provided in Section 5.04 hereof.

        Credit Agreement - shall mean any agreement between the Company and a
Credit Facility Issuer relating to a Credit Facility, as such agreement may be
amended or supplemented from time to time pursuant to its terms and initially
means the Reimbursement Agreement dated April 24, 1997 between the Bank and the
Company.

        Credit Facility - shall mean the Letter of Credit or any Alternate
Credit Facility.

        Credit Facility Issuer - shall mean the Bank with respect to the Letter
of Credit or the institution issuing any Alternate Credit Facility.

        Department - shall mean the Texas Department of Commerce and any
successor to its functions and duties.

                                       4
<PAGE>

        Event of Default - used with respect to this Agreement, shall mean any
event specified in Section 6.01 hereof.

        Favorable Opinion - shall mean an opinion of Bond Counsel addressed to
the Issuer, the Company, the Credit Facility Issuer and the Trustee to the
effect that the action proposed to be taken is authorized or permitted by the
Act, the Indenture and this Agreement and will not adversely affect the
excludability from gross income for federal income tax purposes of interest on
the Bonds.

        Fitch - shall mean Fitch Investors Service, L.P. or any successor
thereto maintaining a rating on the Bonds; provided that if such rating agency
does not then rate the Bonds, the term "Fitch" shall refer to any national
rating agency which provides such a rating.

        GAAP - shall mean generally accepted accounting principles as in effect
as of the time of application to the provisions hereof (unless otherwise noted).

        Governmental Unit - shall mean Bastrop County, Texas, and any successor
to its functions and duties.

        Indenture - shall mean the Indenture of Trust, dated as of April 1,
1997, between the Issuer and the Trustee, as originally executed and as amended,
modified or supplemented thereafter in accordance with the terms thereof.

        Inducement Resolution - shall mean the "Resolution Taking Affirmative
Official Action Towards the Issuance of the Bonds to Provide a Manufacturing
Project for Stratagene" adopted by the Issuer on January 7, 1997.

        Issue Date - shall mean the date on which the Bonds are first
authenticated and delivered to the initial purchasers against payment therefor.

        Issuer - shall mean Bastrop County Industrial Development Corporation, a
nonstock, nonprofit industrial development corporation existing under the laws
of the State of Texas.

        Letter of Credit - shall mean the irrevocable letter of credit delivered
on the Issue Date by the Bank to the Trustee.

        Loan - shall mean the loan made by the Issuer to the Company from the
proceeds of the Bonds pursuant to this Agreement.

        Loan Payment - shall mean each payment required to pay amounts due and
owing on the Bonds issued pursuant to this Agreement, as provided in Sections
5.01 and 5.09 hereof and as provided for in the Indenture, including the
principal of, premium, if any, and interest on, and Purchase Price of, the
Bonds.

        Outstanding, Bonds Outstanding or Bonds then Outstanding - shall mean
when used with reference to Bonds at any date as of which the amount of
Outstanding Bonds is to be determined, means all Bonds authenticated and
delivered under the Indenture, except:

                                       5
<PAGE>

             (a) Bonds canceled or delivered for cancellation at or prior to
        such date;

             (b) Bonds deemed tendered or deemed to be paid pursuant to the
        terms of the Indenture;

             (c) Bonds in lieu of which others have been authenticated under the
        Indenture; and

             (d) For purposes of any consent, request, demand, authorization,
        direction, notice, waiver or other action to be taken by the holders of
        a specified percentage of outstanding Bonds hereunder, all Bonds held by
        or for the account of the Issuer or the Company, except that for
        purposes of any such consent, request, demand, authorization, direction,
        notice, waiver or action, the Trustee shall be obligated to consider as
        not being outstanding only Bonds known by the Trustee by actual notice
        thereof to be so held.

        Person - includes an individual, a corporation, an association, a
partnership, a trust or estate, a government, foreign or domestic, and any
agency or political subdivision thereof, or any other entity.

        Placement Agent - shall mean the placement agent of the Bonds, being
Union Bank of California, N.A.

        Principal Office - is defined in the definitions of Trustee and
Remarketing Agent herein.

        Project - shall mean certain manufacturing facilities located within the
Governmental Unit as described more fully in Exhibit "A" to this Agreement.

        Project Costs - shall mean costs incurred by the Issuer or the Company,
whether incurred before the issuance of the Bonds pursuant to the Inducement
Resolution or thereafter, with respect to the acquisition, construction and
improvement of the Project, including but not limited to, the following items:

    (i) The cost of acquisition, construction, reconstruction, improvement, and
expansion, including the cost of the acquisition of all land, rights-of-way,
property rights, easements, and interests, the cost of all machinery and
equipment, financing charges, inventory, raw materials and other supplies,
research and development costs, interest prior to and during construction and
for one year after completion of construction whether or not capitalized,
necessary reserve fiends, costs of estimates and of engineering and legal
services, plans, specifications, surveys, estimates of cost and of revenue,
other expenses necessary or incident to determining the feasibility and
practicability of acquiring, constructing, reconstructing, improving, and
expanding any such project, administrative expense and such other expense as may
be necessary or incident to the acquisition, construction, reconstruction,
improvement, and expansion thereof, the placing of the same in operation, and
the financing or refinancing of any such project, including the refunding of any
outstanding obligations, mortgages, or advances issued, made or given by any
person for any of the aforementioned costs;

                                       6
<PAGE>

             (ii) To the extent authorized by the Act, costs of all other items
        related to the acquisition, construction and improvement of the Project;
        and

             (iii) All Costs of Issuance.

        Purchase Date - shall mean the date upon which Bonds are required to be
purchased pursuant to a mandatory or optional tender in accordance with the
provisions in the form of Bonds set forth in Section 2.03 of the Indenture.

        Purchase Price - shall have the meaning set forth in the form of Bonds
set forth in Section 2.03 of the Indenture.

        Rebate Fund - shall mean the fund by that name established in Section
4.10 of the Indenture.

        Regulations - shall mean the income tax regulations promulgated.
pursuant to the Code.

        Remarketing Agent - shall mean the initial and any successor remarketing
agent appointed in accordance with Article VIII of the Indenture. Principal
Office of the Remarketing Agent shall mean the office thereof designated in
writing to the Trustee and the Credit Facility Issuer.

        Remarketing Agreement - shall mean the Remarketing Agreement dated as of
April 1, 1997 between the Company, the Trustee and the Remarketing Agent or any
similar agreement executed pursuant to Article VIII of the Indenture.

        State - shall mean the State of Texas.

        Tax Letter of Representation - shall mean the letter of representation
regarding the use of the proceeds of the Bonds and other facts that are within
the Company's knowledge, furnished by the Company to the Issuer in connection
with the issuance of the Bonds.

        Trustee - shall mean First Bank National Association, or any successor
trustee or co-trustee serving as such under the Indenture. Principal Office of
the Trustee shall mean the business address designated in writing to the Issuer
and the Remarketing Agent as its principal office for its duties under the
Indenture.

        Trustee's Prime Rate - shall mean, on any day, the rate announced as
such by the Trustee acting in its commercial capacity or the Bank's reference
rate in the event the Trustee does not announce a prime rate.

        Unassigned Rights - shall mean the rights of the Issuer under Sections
5.04, 6.01, 6.02, 6.03 and 7.03(a) of this Agreement and the right to receive
notices under this Agreement.

        Section 1.02. ARTICLE AND SECTION HEADINGS. The headings or titles of
the several Articles and Sections of this Agreement, and the Table of Contents
appended hereto, are solely for convenience of reference and shall not affect
the meaning or construction of the provisions hereof.

                                       7
<PAGE>

        Section 1.03. INTERPRETATION. The singular form of any word used herein
shall include the plural, and vice versa, if applicable. The use of a word of
any gender shall include all genders, if applicable. The Indenture and all of
the terms and provisions hereof shall be construed so as to effectuate the
purposes contemplated hereby and to sustain the validity hereof. All references
to any person or entity defined in Section 1.01 shall be deemed to include any
person or entity succeeding the rights, duties and obligations of such person or
entity. Unless otherwise specified herein, all references to specific times
shall be deemed to refer to New York City time.

                                   ARTICLE II

                                 REPRESENTATIONS

        Section 2.01. REPRESENTATIONS BY ISSUER. The Issuer makes the following
representations as the basis for the undertakings on its part herein contained:

        (a) The Issuer is a nonstock, nonprofit industrial development
corporation organized and existing under the laws of the State, particularly,
the Act. The Issuer has all requisite power and authority under the Act (i) to
adopt the Bond Resolution, (ii) to issue the Bonds, and (iii) to enter into, and
perform its obligations under, this Agreement, the Bonds and the Indenture.

        (b) The Issuer is a duly constituted authority and public
instrumentality of the Governmental Unit, a governmental agency and body politic
and corporate of the State, within the meaning of the Regulations and the
rulings of the Internal Revenue Service prescribed and promulgated pursuant to
Section 103 of the Code, and the Issuer is functioning and acting solely on
behalf of the Governmental Unit.

        (c) There are no actions, suits, proceedings, inquiries or
investigations pending or to the knowledge of the Issuer threatened, against or
affecting the Issuer in any court or before any governmental authority or
arbitration board or tribunal, which involve the possibility of materially and
adversely affecting the transactions contemplated by this Agreement or the
Indenture or which, in any way, would adversely affect the validity or
enforceability of the Bonds, the Indenture or this Agreement or the ability of
the Issuer to perform its obligations under the Indenture, the Bonds or this
Agreement.

        (d) The adoption of the Bond Resolution, the issuance and sale of the
Bonds and the execution and delivery by the Issuer of this Agreement and the
Indenture, and the compliance by the Issuer with all of the provisions of each
thereof and of the Bonds (i) are within the powers and authority of the Issuer,
(ii) have been done in full compliance with the provisions of the Act, are legal
and will not conflict with or constitute on the part of the Issuer a violation
of or a breach of or default under, or result in the creation of any lien,
charge or encumbrance upon any property of the Issuer (other than as
contemplated by this Agreement and the Indenture) under the provisions of, any
charter instrument, by-law, indenture, mortgage, deed of trust, note agreement
or other agreement or instrument to which the Issuer is a party or by which the
Issuer is bound, or any license, judgment, decree, law, statute, order, rule or
regulation of any court or governmental agency or body having jurisdiction over
the Issuer or any of its activities or properties, and (iii) have been duly
authorized

                                       8
<PAGE>

by all necessary action on the part of the Issuer.

        (e) Neither the nature of the Issuer nor any of its activities or
properties, nor any relationship between the Issuer and any other person, nor
any circumstance in connection with the offer, issue, sale or delivery of any of
the Bonds is such as to require the consent, approval or authorization of, or
the filing, registration or qualification with, any governmental authority on
the part of the Issuer in connection with the execution, delivery and
performance of this Agreement and the Indenture or the offer, issue, sale or
delivery of the Bonds, other than those already obtained as of the date of issue
of the Bonds; provided, however, no representation is made herein as to
compliance with the securities or "blue sky" laws of any jurisdiction.

        (f) No event has occurred and no condition exists with respect to the
Issuer which would constitute an "Event of Default" under this Agreement or
under the Indenture or which, with the lapse of time or with the giving of
notice or both, would become an "Event of Default" under this Agreement or under
the Indenture.

        (g) Neither this Agreement nor the security for the Bonds has been
pledged or hypothecated in any manner or for any purpose other than as provided
in the Indenture as security for the payment of the Bonds.

        (h) Notwithstanding anything herein contained to the contrary, any
obligation the Issuer may hereby incur for the payment of money shall not
constitute an indebtedness of the State or of any political subdivision thereof
within the meaning of any state constitutional provision or statutory limitation
and shall not give rise to a pecuniary liability of the State or a political
subdivision thereof, or constitute a charge against the general credit or taxing
power of the State or a political subdivision thereof or general funds or assets
of the Issuer (including funds relating to other Issuer loans or activities),
but shall be limited obligations of the Issuer payable solely from (i) the
security for the Bonds, (ii) revenues derived from the sale of the Bonds, and
(iii) amounts on deposit from time to time under the Indenture, subject to the
provisions of this Agreement and the Indenture permitting the application
thereof for the purposes and on the terms and conditions set forth herein and
therein.

        (i) The Project is a manufacturing project located within the boundaries
of the Governmental Unit.

        (j) The Issuer represents to the Department that the (1) Project will
contribute to the economic growth or stability of the Governmental Unit by (aa)
increasing or stabilizing employment opportunities within the boundaries of the
Governmental Unit, (bb) significantly increasing or stabilizing the property tax
base of the Governmental Unit and (cc) promoting commerce within the boundaries
of the Governmental Unit and the State; and (2) it has no present intention of
directing the Project to a use other than the purposes represented to the
Governmental Unit and the Department.

        Section 2.02. REPRESENTATIONS BY COMPANY. The Company makes the
following representations as the basis for the undertakings on its part herein
contained:

        (a) The Company (i) is a limited partnership duly organized and in good
standing in the

                                       9
<PAGE>

State of Delaware and is qualified to conduct business and is in good standing
in the State of Texas, (a) is not in violation of any provision of its
partnership agreement, (iii) has full authority to own its properties and
conduct its business, (iv) has full legal right, power and authority to enter
into this Agreement and consummate, or cause to be consummated, all transactions
contemplated by this Agreement and (v) by proper action has duly authorized the
execution and delivery of this Agreement.

        (b) Neither the execution and delivery by the Company of this Agreement
nor the consummation by the Company of the transactions contemplated by this
Agreement conflicts with, will result in a breach of or default under or will
result in the imposition of any lien on any property of the Company pursuant to
the partnership or other agreements of the Company or the terms, conditions or
provisions of any statute, order, rule, regulation, agreement or instrument to
which the Company is a party or by which it is bound.

        (c) This Agreement has been duly authorized, executed and delivered by
the Company and constitutes the legal, valid and binding obligation of the
Company in accordance with its terms.

        (d) There is no litigation or proceeding pending, or to the knowledge of
the Company threatened, against the Company which could adversely affect the
validity of this Agreement or the ability of the Company to comply with its
obligations under this Agreement.

        (e) All statements of facts or other information furnished by the
Company to Bond Counsel in connection with Bond Counsel's opinion relating to
the Bonds, including particularly the Tax Letter of Representation, were true
and correct when made and nothing has come to the Company's attention that would
change the truth or correctness of such statements of facts or other information
furnished by the Company to Bond Counsel.

        (f) The Company represents to the Issuer and the Department that the
Project will contribute to the economic growth or stability of the Governmental
Unit by (aa) increasing or stabilizing employment opportunities within the
boundaries of the Governmental Unit, (bb) significantly increasing or
stabilizing the property tax base of the Governmental Unit and (cc) promoting
commerce within the boundaries of the Governmental Unit and the State. In
addition, the Company has no present intention of (aa) using or moving any
portion of the Project outside the State or disposing of or abandoning the
Project; and (bb) directing the Project to a use other than the purpose
represented to the Governmental Unit and the Department. No car, truck, mobile
unit or any vehicle of any kind whatsoever, which is financed in whole or in
part by the proceeds of the Bonds, will be away from the Project for more than
30 continuous calendar days and that all cars, trucks, mobile units or vehicles
of any kind whatsoever, financed in whole or in part by the proceeds of the
Bonds, will be rendered on the local tax rolls. By virtue of the Project being
financed under the Act, the Company has not and will not maintain that it is
entitled to an exemption from Texas sales or use taxes on personal property
acquired in connection with the Project.

                                       10
<PAGE>

                                  ARTICLE III

                                  THE PROJECT

        Section 3.01. APPROVALS AND PERMITS. The Issuer and the Company agree to
use their best efforts to obtain the necessary approval of this Agreement by the
Department as required by the Act, prior to the issuance of the Bonds, and the
Company, with regards to its use of the Project, agrees to use its best efforts
to obtain, or cause to be obtained, all other permits necessary with respect to
the acquisition, construction, equipping, and furnishing of the Project.

        Section 3.02. ACQUISITION AND CONSTRUCTION. (a) The acquisition,
construction, equipment and furnishing of the Project shall be completed with
all reasonable dispatch, and the Issuer and the Company will use their best
efforts to cause such acquisition, construction, equipping, and furnishing to be
completed as soon as practicable, but if for any reason there should be delays
in such acquisition, construction, equipping, and furnishing there shall be no
diminution in or postponement of the Loan Payments to be made by the Company
hereunder, and no resulting liability on the part of the Issuer.

        (b) The Issuer shall loan the proceeds from the sale of the Bonds to the
Company to be used to pay all or part of the Project Costs incurred or to be
incurred by the Company. It is specifically provided, however, that none of the
proceeds from the sale of the Bonds will be used to reimburse the Company for
(and the Company hereby covenants and agrees not to request reimbursement of)
any part of the Project Costs if such use would result in a violation of any of
the Company's representations contained in Section 2.02 or the Tax Letter of
Representation. However, if for any reason, the proceeds of the Bonds are not
sufficient to pay all of the Project Costs incurred or to be incurred by the
Company, such Project Costs not paid from the proceeds of the Bonds shall be
funded or financed solely by the Company.

        Section 3.03. CONSTRUCTION FUND. The Construction Fund, as defined in
and required by the Indenture, shall be drawn on and used to pay the Costs of
Issuance of the Bonds and Project Costs when due and payable. The Issuer shall
deposit the proceeds from the sale and delivery of the Bonds as follows: (1)
accrued interest, if any, in the Bond Fund, and (2) the remainder in the
Construction Fund. The Trustee, pursuant to request of the Company, shall draw
on and use the Construction Fund as follows:

        (a) Immediately after the delivery of the Bonds, the Company, or the
Trustee, upon written direction of the Authorized Company Representative, shall
pay directly (i) to the Issuer, the amounts, if any, owed to the Issuer and
Governmental Unit specified in Section 5.04 hereof, (ii) reasonable fees and
expenses of bond counsel and Placement Agent, (iii) reasonable fees and expenses
of the Issuer's and the Governmental Unit's general counsel, and (iv) reasonable
fees and expenses of the Bank and its counsel, all such costs being Costs of
Issuance. Further, the Trustee shall retain such reasonable amounts, upon
written direction of the Authorized Company Representative, to pay its initial
acceptance fee and expenses and fees and expenses of its counsel.

        (b) The Trustee shall make payment to the Company, upon the written
request of the Authorized Company Representative from the Construction Fund in
an amount sufficient to reimburse

                                       11
<PAGE>

the Company for Project Costs incurred by the Company up to the date of such
written request.

        (c) In case the cumulative total amount for Costs of Issuance exceeds
two percent of the proceeds of the Bonds (exclusive of any original issue
discount), the Company agrees to pay out-of-pocket all such Costs of Issuance
that exceed two percent of the proceeds of the Bonds.

        (d) The Trustee shall make payments to the Company, upon written
direction of the Authorized Company Representative, for Project Costs incurred
after the delivery of the Bonds. Such written direction shall be in
substantially the form set forth in Exhibit "B" attached hereto.

        (e) The Trustee shall rely fully on any such request and certificate
delivered pursuant to this Section and shall not be required to make any
investigation in connection therewith. If amounts paid by the Trustee pursuant
to (b) above with respect to any portion of the Project exceed the cost thereof,
the Company shall promptly repay such overpayment into the Construction Fund.

        (f) The Issuer hereby gives its express written authority to the Company
to direct the investment of the Construction Fund by the Trustee as hereinafter
provided and as permitted by the Indenture. Any money held as part of the
Construction Fund shall be invested or reinvested by the Trustee in the same
manner as provided for money on deposit in the Bond Fund. Upon acceleration of
the maturity of the Bonds pursuant to the Indenture, subject to am amounts that
must be rebated to the United States of America as set forth in Section 4.10 of
the Indenture, any amounts held in or on deposit in the Construction Fund shall
be transferred by the Trustee to the Bond Fund.

        (g) If, upon delivery of the Completion Certificate, there shall be any
surplus funds remaining in the Construction Fund not required to reimburse the
Company for any eligible Project Costs, such funds shall, upon the written
request of the Authorized Company Representative and the Credit Facility Issuer,
be used by the Trustee (i) to purchase for cancellation Bonds at any reasonable
price as determined by the Authorized Company Representative, which price,
however, shall not exceed the principal amount thereof plus accrued interest
thereon; (ii) to be transferred to the Bond Fund to pay amounts owing on the
Bonds; or (iii) for any combination of (i) and (ii) above. If the Bonds are then
subject to redemption at par, any of such funds not to be used in a manner set
forth in (i), (ii) or (iii) above shall be applied to redeem Bonds in the
largest principal amount then subject to redemption at par that does not exceed
the amount of such funds. Any of such surplus funds in the Construction Fund
transferred to the Trustee and not to be applied for the purposes set forth in
(i), (ii), or (iii) above or which may not be applied to redeem Bonds as set
forth above shall be deposited in the Bond Fund and moneys on deposit therein
such escrow account shall, at the written request of an Authorized Company
Representative and the Credit Facility Issuer, be applied to pay the principal
of Bonds upon redemption thereof on the earliest practicable redemption date
upon which such Bonds may be redeemed at par; provided, that any such moneys
held in the Bond Fund shall be invested in accordance with Section 4.05 of the
Indenture but may not be invested to produce a yield greater than the yield on
the Bonds.

        Section 3.04. COMPLETION CERTIFICATE. At such time as the Company
determines that construction of the Project has been completed or has determined
to terminate any further construction of the Project, it shall deliver the
Completion Certificate to the Issuer, the Company, the Credit Facility Issuer
and the Trustee. The delivery of the Completion Certificate, for any reason,

                                       12
<PAGE>

shall not affect the Company's obligation to make Loan Payments under this
Agreement.

        Section 3.05. ISSUER'S LIMITED LIABILITY. It is recognized that the
Issuer's only source of funds with which to carry out its commitments under this
Agreement will be from the proceeds from the sale of the Bonds or from any
available income or earnings derived therefrom, or from any funds which
otherwise might be made available by the Company, and it is expressly agreed
that the Issuer shall have no financial liability, obligation, or responsibility
with respect to this Agreement except to the extent of funds available from such
sources.

                                   ARTICLE IV

                           ISSUANCE OF BONDS; THE LOAN

        Section 4.01. ISSUANCE OF BONDS. The Issuer, concurrently with the
execution of this Agreement, will sell, issue and deliver to the initial
purchasers thereof the Bonds, all in accordance with the Indenture.

        Section 4.02. THE LOAN. (a) The Issuer shall make the Loan to the
Company by depositing into the Construction Fund and the Bond Fund, if
applicable, the proceeds from the sale of the Bonds in such amounts as are
provided in the Indenture. The amounts so deposited shall be advanced in the
manner provided herein and in the Indenture; and, in consideration thereof, the
Company shall make the Loan Payments as provided in this Agreement and the
Indenture.

        (b) Notwithstanding any provision expressly or inferentially to the
contrary contained herein, the Company unconditionally agrees that it shall make
or cause to be made Loan Payments in immediately available funds to the Trustee
(pursuant to an assignment by the Issuer to the Trustee, as hereinafter
described) in lawful money of the United States of America. Upon the issuance
and delivery of the Bonds to the initial purchasers thereof, and the deposit of
the proceeds derived therefrom into the accounts established in the Indenture,
the Company shall have received, and the Issuer shall have given, full and
complete consideration for the Company's obligation hereunder to make Loan
Payments.

        Section 4.03. SECURITY FOR THE BONDS. The obligations of the Company
under this Agreement, including specifically the obligation to make Loan
Payments as provided in Sections 5.01 and 5.03 hereof shall be direct general
obligations of the Company. Prior to or simultaneously with the issuance of the
Bonds, the Issuer will assign to the Trustee under the terms of the Indenture
all of the Issuer's right, title, and interest in and to the Loan Payments and
certain other rights under this Agreement as provided in the Indenture.

        Section 4.04. REFUNDING OF BONDS. After the issuance of any Bonds, the
Issuer shall not refund any of the Bonds or change or modify the Bonds in any
way, except as provided for in the Indenture, without the prior written approval
of the Authorized Company Representative, the Credit Facility Issuer and the
Department, nor shall the Issuer, at the direction of the Company, redeem any
Bonds prior to their scheduled maturities except upon the written request of the
Authorized Company Representative and approved by the Credit Facility Issuer,
unless such redemption is required by the

                                       13
<PAGE>

Indenture.

                                    ARTICLE V

                             THE COMPANY'S PAYMENTS

        Section 5.01. COMPANY APPROVAL OF ISSUANCE OF BONDS. (a) Simultaneously
with the authorization of this Agreement by the Board of Directors of the
Issuer, such Board has adopted the Bond Resolution. In consideration of the
covenants and agreements set forth in this Agreement, and to enable the Issuer
to issue the Bonds to carry out the intents and purposes hereof, this Agreement
is executed to assure the issuance of such Bonds, and to provide for the due and
punctual payment by the Company to Trustee as assignee of the Issuer under the
Indenture securing the Bonds, of amounts not less than those required to pay, as
and when due (whether at stated maturity, upon redemption, acceleration of
maturity, tender, deemed tender, or otherwise), all of the principal of,
redemption or other premium, if any, and interest on, and Purchase Price of, the
Bonds. Each such payment is hereby designated as a "Loan Payment," and
collectively such payments are hereby designated as "Loan Payments." The
Company hereby agrees to make, or cause to be made, each Loan Payment, as and
when due, for the benefit of the owners of the Bonds into the Bond Fund
(excluding any Purchase Price component of such payment and as provided in
Section 5.09 hereof), as provided in the Indenture.

        (b) By execution and delivery of this Agreement, the Company hereby
approves the Bond Resolution and the Indenture. It is hereby agreed that the
foregoing approval of the Bond Resolution and the Indenture constitutes the
acknowledgement and agreement of the Company that the Bonds, when issued, sold,
and delivered as provided in the Bond Resolution and the Indenture, will be
issued in accordance with and in compliance with this Agreement, notwithstanding
any other provisions of this Agreement or any other contract or agreement to the
contrary. Any Bondholder is entitled to rely fully and unconditionally on the
foregoing approval. Notwithstanding any provisions of this Agreement or any
other contract or agreement to the contrary, the Company's approval of the Bond
Resolution and the Indenture shall be the Company's agreement that all covenants
and provisions in this Agreement and the Indenture affecting the Company shall,
upon the delivery of the Bonds and the Indenture, become unconditional, valid,
and binding covenants and obligations of the Company so long as the Bonds and
the interest thereon are outstanding and unpaid. Particularly, the obligation of
the Company to make, promptly when due, all Loan Payments specified in this
Agreement and the Indenture shall be absolute and unconditional, and said
obligation may be enforced as provided in this Agreement and the Indenture.

        Section 5.02. PAYMENT UPON REDEMPTION OF BONDS. The Issuer, upon the
written request of the Company (provided that such request is received in
sufficient time prior to the date upon which such redemption or prepayment is
proposed), forthwith shall take or cause to be taken all action that may be
necessary under the applicable redemption provisions of the Indenture to effect
such redemption prior to maturity, to the full extent of funds either made
available for such purpose by the Company or already on deposit under the
Indenture and available for such purpose. The redemption of any outstanding
Bonds prior to maturity at any time shall not relieve the Company of its
absolute and unconditional obligation to pay each remaining Loan Payment with
respect to any

                                       14
<PAGE>

outstanding Bonds, as specified in the Indenture. If a redemption of Bonds is
required pursuant to the provisions of the Indenture, the Company agrees as
provided herein to forthwith make Loan Payments sufficient to pay the principal
of, premium, if any, and interest on the Bonds.

        Section 5.03. LOAN PAYMENTS. (a) Payment of all Loan Payments shall be
made and deposited so as to fund payment on the Bonds as required by the
Indenture, including all such payments which may come due because of the
acceleration of the maturity or maturities of the Bonds upon default, call for
redemption, purchase or deemed purchase, or otherwise, under the provisions of
the Indenture. If any available funds in excess of current requirements are held
on deposit in the Bond Fund at the time payment of any Loan Payment is due, such
payment of Loan Payment shall be reduced by the amount of the available funds so
held on deposit, to the benefit of the Company. The Loan Payments, together with
available funds held on deposit in the Bond Fund, except funds held therein for
payment of matured installments of principal on the Bonds or interest payable
thereon, shall be sufficient to pay when due all principal of, redemption
premium, if any, and interest on, and Purchase Price of, the Bonds. The Company
shall have the right to prepay or cause to be prepaid all or a portion of each
Loan Payment at any time, and shall be obligated to do so in a timely manner if
and to the extent the Company requests redemption or prepayment of the Bonds.
Any such prepayment by the Company shall not relieve it of liability for each
remaining Loan Payment with respect to the Outstanding Bonds except as provided
in this Agreement and the Indenture. In the event the Company should fail to
make any of the payments required in this Section 5.03, the amount so in default
shall continue as an obligation of the Company until such amount in default
shall have been fully paid, and the Company agrees to pay the same with interest
thereon to the extent permitted by law at the rate of interest borne by the
Bonds at the time of such failure from the due date thereof until paid.

        (b) Notwithstanding any provisions of this Agreement to the contrary,
any amounts drawn by the Trustee under any Credit Facility shall be credited
against the obligations of the Company to make Loan Payments.

        Section 5.04. PAYMENTS TO ISSUER AND GOVERNMENTAL UNIT. Out of money
from the proceeds from the sale and delivery of the Bonds or out of funds
provided by the Company, there shall be paid all of the Issuer's and
Governmental Unit's reasonable actual out-of-pocket expenses and Costs of
Issuance in connection with the Bonds.

        Section 5.05. ISSUER'S RIGHTS ASSIGNED TO TRUSTEE. The Company is
advised and recognizes that as security for the payment of the Bonds, the Issuer
will assign to the Trustee the Issuer's rights under this Agreement, including
the right to receive payments hereunder (except for the rights of the Issuer
under Sections 6.01 and 6.02 hereof, the right to receive payments, if any,
under Sections 5.04, 6.03, and 7.03(a) hereof and the right to receive notices
under this Agreement), and hereby directs the Company to make said payments
directly to the Trustee. The Company herewith assents to such assignment and
will make such payments directly to the Trustee without defense or set-off by
reason of any dispute between the Company and the Issuer or the Trustee. All
rights against the Company arising under this Agreement or the Bond Resolution
or Indenture and assigned to the Trustee under the Indenture may be enforced by
the Trustee, or the owners of the Bonds, to the extent provided in the
Indenture, and the Trustee, or the owners of the Bonds, shall be entitled to
bring any suit, action, or proceeding against the Company, to the extent
provided in the

                                       15
<PAGE>

Bond Resolution or Indenture, for the enforcement of this Agreement, and it
shall not be necessary in any such suit, action, or proceeding to make the
Issuer a party thereto.

        Section 5.06. PAYMENTS TO TRUSTEE. The Company agrees to pay (1) the
initial acceptance fee of the Trustee, as disclosed to and agreed to by the
Company, and reasonable costs and expenses, including reasonable attorneys fees,
incurred by the Trustee in entering into and executing the Indenture and (2)
until the principal of, premium, if any, and interest on the Bonds shall have
been fully paid or provision for the payment thereof shall have been made in
accordance with the provisions of the Indenture, (i) an amount equal to the
reasonable annual fee of the Trustee, as disclosed to and agreed by the Company
for the ordinary services of the Trustee, as trustee, rendered and its
reasonable ordinary expenses incurred under the Indenture, including reasonable
attorneys fees, as and when the same become due, (ii) the reasonable fees,
charges and expenses of the Trustee, as bond registrar and as paying agent, and
any other bond registrar or paying agent on the Bonds, as and when the same
become due, (iii) the reasonable fees, charges and expenses of the Trustee for
the necessary extraordinary services rendered by it and extraordinary expenses
incurred by it under the Indenture or this Agreement, as and when the same
become due, including reasonable attorneys fees, and (iv) the cost of printing
or producing any Bonds required to be furnished by the Issuer. All fees due
hereunder shall be agreed between the Trustee and the Company and all costs and
expenses shall be deemed due within ten (10) days of written notice to the
Company that the same have been incurred. In the event the Company should fail
to make any of the payments required in this Section 5.06, the item or
installments so in default shall continue as an obligation of the Company until
the amount in default shall have been fully paid, and the Company agrees to pay
the same with interest thereon, to the extent permitted by Section 5.10 hereof
at the Trustee's Prime Rate at the time of such failure from the due date
thereof until paid.

        Section 5.07. PAYMENT TO REMARKETING AGENT. The Company agrees to pay to
the Remarketing Agent, the reasonable fees, costs and expenses of the
Remarketing Agent incurred under and pursuant to the Remarketing Agreement.

        Section 5.08. RESERVED FOR FUTURE USE.

        Section 5.09. PURCHASE OF BONDS. (a) In consideration of the issuance of
the Bonds by the Issuer, but for the benefit of the owners of the Bonds, the
Company has agreed, and does hereby covenant, to cause the necessary
arrangements to be made and to be thereafter continued whereby owners from time
to time of the Bonds may deliver Bonds for purchase and whereby such Bonds shall
be so purchased to the extent, and under the terms and conditions, set forth in
the Indenture. In furtherance of the foregoing covenant of the Company, the
Issuer, at the direction of the Company, has set forth in Section 2.06(b) of the
Indenture the terms and conditions relating to the delivery of Bonds by the
registered holders thereof to the Remarketing Agent for purchase and has set
forth in the Indenture and the Remarketing Agreement the duties and
responsibilities of the Remarketing Agent with respect to the purchase and
remarketing of Bonds. The Company hereby authorizes and directs the Remarketing
Agent to purchase, offer, sell, and deliver Bonds in accordance with the
provisions of Section 2.06(b) of the Indenture.

        Without limiting the generality of the foregoing covenant of the
Company, the Company

                                       16
<PAGE>

covenants, for the benefit of the owners of the Bonds, to pay, or cause to be
paid, to the Trustee such amounts as shall be necessary to enable the Trustee to
pay the Purchase Price of the Bonds (as a component of the Loan Payments)
delivered to it for purchase or deemed delivered for purchase, all as more
particularly described, at the direction of the Company, in the Indenture to be
deposited in the Bond Purchase Fund for the benefit of tendered Bondholders;
provided, however, that the obligation of the Company to make, or cause to be
made, any such payment hereunder shall be satisfied only by funds received by
the Trustee from the remarketing of the Bonds by the Remarketing Agent or, in
the event sufficient funds are not available from such remarketing, from draws
upon the Credit Facility, from the Company.

        (b) The Issuer shall have no obligation or responsibility, financial or
otherwise, with respect to the purchase of Bonds or the making or continuation
of arrangements therefor other than as expressly set forth in subsection (a) of
this Section 5.09, except that the Issuer shall generally cooperate with the
Company, the Credit Facility Issuer and the Remarketing Agent as contemplated by
the Indenture.

        Section 5.10. USURY. Anything herein to the contrary notwithstanding, it
is the intention of the parties hereto to conform strictly to the usury laws in
force that are applicable to this transaction. Accordingly, all agreements among
the parties hereto and beneficiaries hereof and their assigns or any of them,
whether now existing or hereafter arising, and whether written or oral, are
hereby limited so that in no contingency, whether by reason of acceleration of
amounts due hereunder or any part thereof or otherwise, shall the interest
(including all sums that are deemed to be interest) contracted for, charged or
received hereunder exceed the maximum amount permissible under applicable law.
The parties hereto agree that to the extent interest is payable by the Company
under this Agreement, Article 5069-1.04, Vernon's Annotated Texas Civil
Statutes, as amended, shall apply, and, to the extent Article 5069-1.04 is
applicable to this Agreement, the indicated rate ceiling thereunder shall apply.

        Section 5.11. LETTER OF CREDIT. (a) In order to further secure the
payment of principal of and interest on, and Purchase Price of, the Bonds, when
due, prior to the initial delivery of the Bonds the Company shall secure and
deliver to the Trustee, for the benefit of the owners of the Bonds, the Letter
of Credit as the initial Credit Facility under the Indenture. The Letter of
Credit shall be in an original aggregate amount specified in the Indenture, and
the Letter of Credit and any Alternate Credit Facility shall conform to the
requirements set forth in the Indenture. After the initial delivery of the
Letter of Credit, and at all times thereafter while any of the Bonds are
Outstanding, the Company shall continuously secure the Bonds by either
extensions of the Letter of Credit or by securing and delivering an Alternate
Credit Facility. The Company hereby authorizes the Trustee to seek payment under
any Credit Facility in accordance with its terms and the terms of the Indenture.
As long as the Credit Facility is in effect and the Credit Facility Issuer is
not in default thereunder, the Company's obligation is to make Loan Payments
sufficient hereunder to pay principal of, premium, if any, or interest on the
Bonds or to pay Purchase Price of the Bonds shall be satisfied solely from
payments made by the Credit Facility Issuer pursuant to the Credit Facility.
Amounts drawn by the Trustee under any Credit Facility shall be credited against
the obligation of the Company to make Loan Payments hereunder.

        (b) The Company shall give notice, or cause notice to be given, not less
than forty-five

                                       17
<PAGE>

(45) days prior to the expiration of the Credit Facility then in effect, to the
Trustee, the Issuer and the Credit Facility Issuer, that the Credit Facility
then in effect will not be extended or replaced or that the Company will cause
an Alternate Credit Facility to be delivered to the Trustee not less than twenty
(20) days prior to the expiration of the Credit Facility then in effect.

        (c) The Company, the Trustee, and the Credit Facility Issuer, with the
written consent of the Issuer, may, without the consent of the Bondholders,
amend, change, or modify any Credit Facility (i) to cure any ambiguity, formal
defect, inconsistency, or minor omission, (ii) to conform to the requirements of
the Indenture or Fitch, or (iii) if such amendment, change or modification is
not prejudicial to the Bondholders in any material respect and the Trustee and
the Credit Facility Issuer receive a Favorable Opinion to such effect.

        (d) The Company shall pay all costs, fees and expenses incurred by the
Trustee and the Issuer in connection with any reissuance, extension or
substitution of any Alternate Credit Facility.

                                   ARTICLE VI

                              DEFAULTS AND REMEDIES

        Section 6.01. EVENTS OF DEFAULT. The occurrence and continuation of any
one of the following shall constitute an "Event of Default" under this Agreement
(an "Event of Default"):

             (a) failure by the Company to pay, when due, Loan Payments with
        respect to principal of or premium, if any, on any Bond; or

             (b) failure by the Company to pay, when due, Loan Payments with
        respect to interest on any Bond; or

             (c) failure by the Company to pay Loan Payments with respect to the
        Purchase Price of any Bond, when due; or

             (d) failure by the Company to observe and perform any covenant,
        condition or agreement on its part required to be observed or performed
        in this Agreement, other than as referred to in (a), (b) or (c) above,
        for a period of 90 days after receipt by the Company of written notice
        specifying such failure and requesting that it be remedied, given to the
        Company by the Issuer or the Trustee, unless the Issuer and the Trustee
        shall agree in writing to an extension of such time prior to its
        expiration; provided further, however, if the failure stated in the
        notice cannot be corrected within the applicable period, the Issuer and
        the Trustee will not unreasonably withhold their consent to an extension
        of such time if corrective action is instituted within the applicable
        period and diligently pursued until the default is corrected; provided
        further, if any such failure obligates the Company to prepay Loan
        Payments because of mandatory redemption of Bonds pursuant to Section
        2.06(a)(i) of the Indenture, and such prepayment is in fact made by the
        Company and Bonds are redeemed as provided in the Indenture, then such
        failure by the Company shall not constitute an Event of Default under
        this Agreement; or

                                       18
<PAGE>

             (e) the occurrence of an Act of Bankruptcy and, if occurring by
        reason of clause (b) of the definition thereof, such petition resulting
        therefrom shall not be stayed or denied, or a proceeding resulting
        therefrom shall not be discharged, within 90 days after the filing of
        such petition or the commencement of such proceeding, as the case may
        be; or

             (f) receipt by the Trustee of a written notice from the Credit
        Facility Issuer of the occurrence and continuance of an "Event of
        Default" (as defined in the Credit Agreement) and directing that the
        Bonds be called; or

             (g) the occurrence of an "Event of Default" under the Indenture.

        Section 6.02. REMEDIES ON DEFAULT. (a) Whenever any Event of Default
shall have happened and is subsisting, the Issuer, with the consent of the
Trustee, or the Trustee may take any one or more of the following remedial steps
(subject to the provisions of Article VI of the Indenture), but may exercise the
remedy described in (1) below only if acceleration of the principal amount of
the Bonds has been declared pursuant to Section 6.02 of the Indenture:

             (i) By notice in writing to the Company, declare the unpaid Loan
        Payments to be due and payable immediately, if concurrently with or
        prior to such notice the unpaid principal amount of the Bonds has been
        declared to be due and payable under the Indenture, and upon any such
        declaration the amounts payable under Sections 5.01 and 5.03 hereof
        shall become and shall be immediately due and payable in the amount as
        set forth in Section 6.02 of the Indenture; provided, however, that an
        Event of Default shall be deemed waived and a declaration accelerating
        payment of unpaid Loan Payments payable under this Agreement shall be
        deemed rescinded without further action on the part of the Trustee or
        the Issuer upon any rescission by the Trustee of the corresponding
        declaration of acceleration of the Bonds under Section 6.02 of the
        Indenture.

             (ii) Whatever action at law or in equity may appear necessary or
        desirable to collect the payment and other amounts then due or to
        enforce performance and observance of any obligation, agreement or
        covenant of the Company under this Agreement.

        (b) The Company covenants that, in case an Event of Default shall occur
with respect to the payment of any Loan Payment payable under Sections 5.01 and
5.03 hereof, then, upon written demand of the Trustee (such demand only to be
made upon the consent of the Credit Facility Issuer as provided in Sections 6.02
and 6.03 of the Indenture), the Company will pay to the Trustee the whole amount
that then shall have become due and payable under said Sections 5.01 and 5.03,
with interest thereon to the extent permitted by law at the rate of interest
borne by the Bonds at the time of such demand. In case the Company shall fail
forthwith to pay such amounts upon such demand, the Trustee shall be entitled
and empowered to institute any action or proceeding at law or in equity for the
collection of the sums so due and unpaid, and may prosecute any such action or
proceeding to judgment or final decree, and may enforce any such judgment or
final decree against the Company and collect in the manner provided by law out
of the property of the Company, the moneys adjudged or decreed to be payable.
Any sums collected by the Trustee shall be applied as provided in the Indenture.

                                       19
<PAGE>

        (c) If an Event of Default under Section 6.01(e) hereof shall occur and
be continuing, the Trustee shall be entitled and empowered (subject to Article
VI of the Indenture), by intervention in such proceedings or otherwise, to file
and prove a claim or claims for the whole amount owing and unpaid pursuant to
this Agreement, irrespective of whether the principal of the Bonds or any amount
hereunder shall then be due and payable as therein or herein expressed or by
declaration or otherwise, and irrespective of whether the Trustee shall have
made any demand pursuant to the provisions of this Section 6.02, and, in case of
any judicial proceedings, to file such proofs of claim and other papers or
documents as may be necessary or advisable in order to have the claims of the
Trustee allowed in such judicial proceedings relative to the Company, its
creditors, or its property, and to collect and receive any moneys or other
property payable or deliverable on any such claims, and to distribute the same
after the deduction of its charges and expenses; and any receiver, assignee or
trustee in bankruptcy or reorganization is hereby authorized to make such
payments to the Trustee, and to pay to the Trustee any amount due it for
compensation and expenses, including reasonable counsel fees incurred by it up
to the date of such distribution.

        (d) In case the Issuer, with the consent of the Trustee, or the Trustee
shall have proceeded to enforce its rights under this Agreement and such
proceedings shall have been discontinued or abandoned for any reason or shall
have been determined adversely to the Issuer and/or the Trustee, then and in
every such case the Issuer, the Company and the Trustee shall be restored
respectively to their several positions and rights hereunder, and all rights,
remedies and powers of the Issuer, the Company and the Trustee shall continue as
though no such proceeding had been taken.

        (e) Notwithstanding anything herein to the contrary, so long as the
Credit Facility Issuer is not in default under the Credit Facility: (i) neither
the Issuer nor the Trustee may exercise any remedy provided in this Article VI,
other than acceleration under Section 6.01(a)(i) hereof, without the prior
written consent of the Credit Facility Issuer, and (ii) the Trustee shall upon
the written direction of the Credit Facility Issuer pursue any remedy provided
in this Agreement.

        The remedies for any "Event of Default" under the Indenture shall be as
specified in Article VI of the Indenture and are in addition to any remedies
hereunder.

        In acting or omitting to act pursuant to the provisions of this
Agreement, the Trustee shall be entitled to all of the rights, protections and
immunities accorded to the Trustee under the terms of the Indenture, including
but not limited to those set out in Article VII thereof.

        Section 6.03 AGREEMENT TO PAY ATTORNEYS' FEES AND EXPENSES. In the event
the Company should default under any of the provisions of this Agreement and the
Issuer or the Trustee should employ attorneys or incur other expenses for the
collection of the payments due under this Agreement or the enforcement of
performance or observance of any obligation or agreement on the part of the
Company herein contained, the Company agrees that it will on demand therefor,
and upon presentation of an itemized bill, pay to the Issuer or the Trustee the
reasonable fees of such attorneys and such other reasonable expenses so incurred
by the Issuer or the Trustee.

                                       20
<PAGE>

                                   ARTICLE VII

                                SPECIAL COVENANTS

        Section 7.01. NO DEFENSE OR SET OFF; UNCONDITIONAL OBLIGATION. The
obligations of the Company to make the payments required by this Agreement and
to perform and observe the other agreements on its part contained herein shall
be absolute and unconditional, irrespective of any defense or any rights of
set-off, recoupment or counterclaim it might otherwise have against the Issuer
or any other person, and the Company shall pay during the term of this Agreement
the payments to be made as prescribed in Article V and all other payments
required hereunder free of any deductions and without abatement, diminution or
set-off; and until such time as the principal of, premium, if any, and interest
on the Bonds shall have been fully paid, or provision for the payment thereof
shall have been made in accordance with the Indenture, the Company: (i) will not
suspend or discontinue any payments provided for in Article V hereof; (ii) will
perform and observe all of its other agreements contained in this Agreement; and
(iii) except as permitted herein, will not terminate this Agreement for any
cause, including, without limiting the generality of the foregoing, failure of
the Project to be acquired, constructed, improved, or completed, failure of the
Company to approve, receive, accept or use the Project, destruction of or damage
to the Project, commercial frustration of purpose, any change in the tax laws of
the United States of America or of the State of Texas or any political
subdivision of either of these, or any failure of the Issuer or the Trustee to
perform and observe any agreement, whether express or implied, or any duty,
liability or obligation arising out of or connected with this Agreement or the
Indenture, except to the extent permitted by this Agreement. Nothing contained
in this Section shall be construed to relieve the Issuer or the Trustee from the
performance of any agreements on their respective parts contained herein and the
Company shall be entitled to institute such action against the Issuer or the
Trustee as the Company shall deem appropriate to compel performance of any such
agreement, duty or obligation; provided, however, that the Issuer shall not be
required to carry out any such agreement, duty or obligation unless it is
reimbursed for its costs and expenses.

        Section 7.02. CONSOLIDATION AND MERGER. The Company covenants that
during the term hereof it will not transfer all or substantially all of its
assets to, and will not consolidate with or merge into, another entity; provided
that the Company may consolidate with or merge into a domestic corporation or
entity (i.e., a corporation incorporated or entity created and existing under
the laws of one of the states of the United States or the District of Columbia),
or transfer to a domestic corporation or entity all or substantially all of its
assets; provided that the surviving, resulting or transferee corporation or
entity, as the case may be, if it is other than the Company, (i) is a domestic
corporation or entity as aforesaid and qualified to do business in the State,
and (ii) assumes in writing all of the obligations of the Company under this
Agreement. The Company shall, within fifteen days after the execution thereof,
furnish to the Issuer and the Trustee appropriate documentation demonstrating
that the surviving, resulting or transferee corporation, as the case may be, is
a domestic corporation, is qualified to do business in the State, and has
assumed in writing all of the obligations of the Company under this Agreement.

        Section 7.03. INDEMNITIES. (a) Except as otherwise provided in this
Section 7.03, the Company releases the Department, its directors, employees, and
agents, and the Issuer and the Governmental Unit, their officers, directors,
employees, agents, and attorneys (the "Indemnified

                                       21
<PAGE>

Parties") from, and the Indemnified Parties shall not be liable for, and the
Company agrees and shall protect, indemnify, defend, and hold the Indemnified
Parties harmless from, any and all liability, cost, expense, damage, or loss of
whatever nature (including, but not limited to, attorneys' fees, litigation and
court costs, amounts paid in settlement, and amounts paid to discharge
judgments) directly or indirectly resulting from, arising out of, in connection
with, or related to (i) the issuance, offering, sale, delivery, payment of the
Bonds and the interest thereon, or redemption of the Bonds, the provisions and
rate of interest on the Bonds, the Bond Resolution, the Indenture, and this
Agreement and the obligations imposed on the Issuer hereby and thereby, or the
design, construction, installation, operation, use, occupancy, maintenance, or
ownership of the Project; (ii) any written statements or representations made or
given by the Company or any of its officers or employees, to the Indemnified
Parties, the Trustee, or any underwriters or purchasers of any of the Bonds,
with respect to the Issuer, the Company, the Project, or the Bonds or the offer
or issuance thereof, including, but not limited to, statements or
representations of facts, financial information, or corporate affairs; (iii)
damage to property or any injury to or death of any person that may be
occasioned by any cause whatsoever pertaining to the Company's use of the
Project; (iv) any loss or damage incurred by the Issuer as a result of violation
by the Company of the provisions of Sections 7.04 or 7.05 hereof; and (v) any
action required to be taken by the Issuer under this Agreement, the Bond
Resolution, or the Indenture.

        (b) The Company releases the Trustee, its officers, directors,
employees, agents, and attorneys from, and the Company agrees and shall protect,
indemnify, defend, and hold such parties harmless from any and all liability,
cost, expenses, damage or loss of whatever nature (including, but not limited
to, attorneys' fees, litigation and court costs, amounts paid in settlement, and
amounts paid to discharge judgments) directly or indirectly resulting from,
arising out of or, in connection with (i) the acceptance or administration of
the Indenture or the trusts thereunder or the performance of their duties
thereunder or under this Agreement and (ii) damage to property or any injury to
or death of any person that may be occasioned by any cause whatsoever pertaining
to the Company's use of the Project.

        (c) If any claim is asserted under (a) or (b) above, the party seeking
indemnity will give prompt notice to the Company, and the Company shall have the
sole right and duty to assume, and will assume, the defense thereof with full
power to litigate, compromise, or settle the same in its sole discretion. The
provisions of Sections 7.03(a) and (b) shall remain and be in full force and
effect even if any such liability, cost, expense, damage, or loss or claim
therefor by any person, directly or indirectly results from, arises out of, or
relates to, or is asserted to have resulted from, arise out of, or be related
to, in whole or in part, one or more negligent acts or omissions (other than in
the case of the Trustee, as a result of gross negligence, willful misconduct, or
bad faith on the part of the Trustee) of the party seeking indemnity, in
connection with the matters set forth therein. Notwithstanding the foregoing, in
any action involving the Trustee, the Trustee shall have the right to employ
separate counsel at its own expense.

      Section 7.04.  TAX-EXEMPT STATUS OF INTEREST ON THE BONDS. The Company
and Issuer covenant to refrain from such action which would adversely affect
the treatment of the Bonds as obligations described in Section 103 of the Code,
the interest on which is excludable from "gross income" of the holder for
purposes of federal income taxation. In furtherance thereof, the Company
covenants as follows:

                                       22
<PAGE>
        (a) not to use or invest nor to permit the use or investment of proceeds
of the Bonds (including investment earnings thereon) or the facilities
constituting the Project in a manner that would result in the Bonds not being
"qualified small issue bonds" within the meaning of Section 141(e) of the Code;

        (b) to use at least 95 percent of the proceeds of the Bonds to provide
for the payment of costs of the acquisition, construction, reconstruction,
equipment or improvement of land or depreciable property constituting
"manufacturing facilities", and paid for subsequent to January 7, 1997;

        (c) during the six-year period beginning on a date three years prior to
the date of issue of the Bonds and ending three years after such date, will not
pay or incur or permit any related person or "principal user" of the Project to
pay or incur capital expenditures (within the meaning of Section 263 of the
Code) for facilities located in Bastrop County, Texas to the extent that such
expenditures when added to the aggregate face amount of the Bonds would exceed
$10,000,000;

        (d) that the Company will be the only principal user of the Project;

        (e) that all outstanding obligations the interest on which is exempt
from federal income taxation pursuant to Section 103 of the Code which are
allocated to the Company (or persons related to the Company) do not as of the
date of issue and will not, at any time during the three-year period commencing
on the later of such date or the date on which the Project was
placed-in-service, exceed $40,000,000;

        (f) that the Company will not cause the Bonds to be treated as
"federally guaranteed" obligations for purposes of Section 149 of the Code, as
may be modified in any applicable rules, rulings, policies, procedures,
regulations or other official statements promulgated or proposed by the
Department of the Treasury or the Internal Revenue Service with respect to the
"federally guaranteed" obligations described in Section 149 of the Code as in
effect on the date of this Agreement. For purposes of this paragraph, the Bonds
shall be treated as "federally guaranteed" if (i) all or any portion of the
principal or interest is or will be guaranteed directly or indirectly by the
United States of America or any agency or instrumentality thereof, or (ii) a
significant portion of the proceeds of the Bonds will be (A) used in making
loans the payment of principal or interest with respect to which is to be
guaranteed in whole or in part by the United States of America or any agency or
instrumentality thereof, or (B) invested directly or indirectly in federally
insured deposits or accounts, and (iii) such guarantee is not described in
Section 149(b) of the Code;

        (g) that the Costs of Issuance for the Bonds which are financed with
proceeds of the Bonds will not exceed an amount equal to two percent of the
proceeds received from the sale of the Bonds. Such amounts will not be taken
into account in satisfying the requirement stated above that at least 95 percent
of the Bond proceeds be used to provide the facilities. Any costs of issuance in
excess of two percent shall be an out-of-pocket expense of the Company;

        (h) that no portion of the proceeds of the Bonds are to be used to
provide the following: an airplane, a skybox or other private luxury box, a
facility primarily used for gambling or any store

                                       23
<PAGE>

the principal business of which is the sale of alcoholic beverages for
consumption off premises;

        (i) to comply with the limitations imposed by Section 147(c) of the Code
(relating to the limitation on the use of proceeds to acquire land) and Section
147(d) of the Code (relating to restrictions on the use of bond proceeds to
acquire existing buildings, structures or other property);

        (j) that the Company shall make such use of the proceeds of the Bonds
and any other funds constituting gross proceeds (whether or not held by the
Trustee under the Indenture) which are allocable to the Bonds, restrict the
investment of such proceeds and other funds, and take such further action as may
be required so that the Bonds will not constitute "arbitrage bonds" under
Section 148 of the Code and the regulations. In particular, but not by way of
limitation, the Company covenants that it will provide written instructions to
the Trustee with respect to investments in accordance with the Indenture;

        (k) that the Company shall immediately remit to the Trustee for deposit
in the Rebate Fund any deficiency with respect to the Rebate Amount as required
by Section 4.10 of the Indenture;

        (1) the Company agrees to provide all information required with respect
to Nonpurpose Investments (within the meaning of Section 148 of the Code) not
held in any Fund under the Indenture;

        (m) that, at no time during the period which the Bonds remain
outstanding, will proceeds invested in Nonpurpose Investments (within the
meaning of Section 148 of the Code) at a yield higher than the yield on the
Bonds, other than amounts invested pursuant to an initial temporary period or as
part of a bona fide debt service fund, exceed 150 percent of the debt service on
the issue for the bond year and that the aggregate amount so invested will be
promptly and appropriately reduced as the amount of outstanding obligations
constituting the Bonds is reduced; and

        (n) the Company shall monitor the capital expenditures incurred by it
and by any other "principal user" of the Project, with respect to the Project or
elsewhere within Bastrop County, Texas. Within 30 days after each of the first,
second and third anniversary dates of the issuance of the Bonds, the Company
shall file with the Trustee and the Remarketing Agent a report showing
cumulative capital expenditures which must be counted for purposes of the $10
million capital expenditure limitation contained in Section 144(a) of the Code.
Such report shall be certified as true and accurate by the Authorized Company
Representative.

        The covenants and representations contained in this Section 7.04 are
intended to assure compliance with the Code and any regulations promulgated by
the U.S. Department of Treasury pursuant thereto. In the event that regulations
are hereafter promulgated which modify or expand provisions of the Code, the
Company will not be required to comply with a covenant contained in this section
to the extent that such failure to comply, in the opinion of Bond Counsel, will
not adversely affect the exemption from federal income taxation of interest on
the Bonds under Section 103(a) of the Code. In the event that regulations are
hereafter promulgated which impose additional requirements which are applicable
to the Bonds, the Company and the Issuer agree to comply with such additional
reasonable requirements to the extent necessary, in the opinion of Bond Counsel,
to preserve the exemption from federal income taxation of interest on the Bonds
under Section 103 (a)

                                       24
<PAGE>

of the Code. In furtherance of such intention, the Issuer hereby authorizes and
directs the President or Vice President to execute any documents, certificates
or reports required by the Code and to make such elections, on behalf of the
Issuer, which may be permitted by the Code as are consistent with the purpose
for the issuance of the Bonds.

        The Issuer hereby elects to have the provisions as to the $10 million
limit in Section 144(a)(4) of the Code apply to the Bonds.

        Section 7.05. PAYMENT TO REBATE FUND. The Company hereby covenants and
agrees to make the determinations and to pay any deficiency in the Rebate Fund,
at the times and as described in Section 4.10 of the Indenture. In any event, if
the amount of cash held in the Rebate Fund shall be insufficient to permit the
Trustee to make payment to the United States of any amount due under Section
148(f)(2) of the Code, the Company forthwith shall pay the amount of such
insufficiency on such date to Trustee in immediately available funds. The
obligations of the Company under this Section 7.05 are direct obligations of the
Company, acting under the authorization of, and on behalf of, the Issuer and the
Issuer shall have no further obligation or duty with respect to the Rebate Fund.

        Section 7.06. RECORDATION. The Company agrees that, upon request of the
Bank or Trustee, it will record and re-record and file and refile any of the
financing statements and all supplements and necessary continuation statements
with respect thereto, and such other instruments as may be required from time to
time to be recorded or filed, in such manner and in such places as from time to
time may be required by law in order fully to preserve and protect the
securities of the Owners of the Bonds and the Issuer and the rights of the
Issuer and the Trustee hereunder and under the Indenture.

        Section 7.07 QUALIFICATION IN TEXAS. The Company agrees that, so long as
there are Outstanding Bonds, it will be qualified to do business in the State.

                                  ARTICLE VIII

                               GENERAL PROVISIONS

        Section 8.01. GENERAL PROVISIONS. (a) The terms of this Agreement may be
enforced as to one or more breaches either separately or cumulatively.

        (b) No remedy conferred upon or reserved to the Issuer, the Company or
the Trustee in this Agreement is intended to be exclusive of any other available
remedy or remedies, but each and every such remedy shall be cumulative and shall
be in addition to every other remedy now or hereafter existing at law or in
equity or by statute. No delay or omission to exercise any right or power
accruing upon any default, omission, or failure of performance hereunder shall
impair any such right or power or shall be construed to be a waiver thereof, but
any such right and power may be exercised from time to time and as often as may
be deemed expedient. In the event any provision contained in this Agreement
should be breached by the Issuer or the Company and thereafter duly waived, such
waiver shall be limited to the particular breach so waived and shall not be
deemed to waive any other

                                       25
<PAGE>

breach of this Agreement. No waiver by either party of any breach by the other
party of any of the provisions of this Agreement shall be construed as a waiver
of any subsequent breach, whether of the same or of a different provision of
this Agreement. In view of the assignment of the Issuer's rights in and under
this Agreement to the Trustee under the Indenture, the Issuer shall have no
power to waive any default hereunder by the Company without the consent of the
Trustee. Any waiver of any "Event of Default" under the Indenture and a
rescission and annulment of its consequences shall constitute a waiver of the
corresponding Event of Default hereunder and a rescission and annulment of the
consequences thereof.

        (c) Headings of the Sections of this Agreement have been inserted for
convenience of reference only and in no way shall they affect the interpretation
of any of the provisions of this Agreement.

        (d) This Agreement is made for the exclusive benefit of the Issuer, the
Trustee, the owners of the Bonds, the Credit Facility Issuer and the Company,
and their respective successors and assigns herein permitted, and not for any
other third party or parties; and nothing in this Agreement, expressed or
implied, is intended to confer upon any party or parties other than the Issuer,
the Trustee, the Credit Facility Issuer, and the Company, and their respective
successors and assigns herein permitted, any rights or remedies under or by
reason of this Agreement. In particular, but not by way of limitation, the
Trustee shall be a third-party beneficiary for purposes of enforcing its rights
and the Company's obligations under Sections 5.06 and 7.03 (b) of this Agreement
as fully as if the Trustee had been a party in privity of contract with the
Company hereunder.

        Section 8.02. FINANCIAL STATEMENTS. So long as any of the Bonds are
Outstanding, the Company shall make available for inspection by the Issuer and
any financial advisor of the Issuer (within 150 days after the end of the fiscal
year) a balance sheet of the Company as of the end of such fiscal year and the
related statements of income, cash flows, and change in stockholder's equity for
such fiscal year, all prepared in accordance with GAAP and reported on by a firm
of accountants whose report shall state that such financial statements present
fairly the Company's financial position as of the end of such fiscal year and
the results of operations and cash flows for such fiscal year. Notwithstanding
the foregoing, if the Issuer, the Governmental Unit or the Company becomes
subject to any future laws or regulations relating to continuing disclosure
relating to the Bonds, the Company agrees to provide any and all documentation
and/or financial statements required of it by such laws or regulations.

        Section 8.03. AMENDMENT OF AGREEMENT. No amendment, change, addition to,
or waiver of any of the provisions of this Agreement shall be binding upon the
parties hereto unless in writing signed by the Authorized Company
Representative, the Authorized Issuer Representative and approved in writing by
the Trustee and the Credit Facility Issuer. A copy of any such amendment,
change, addition to, or waiver shall be provided to the Trustee. Notwithstanding
any of the foregoing, it is covenanted and agreed, for the benefit of the
holders of the Bonds, the Trustee and the Credit Facility Issuer, that the
provisions of this Agreement shall not be amended, changed, added to, or waived
in any way which would relieve, reduce or abrogate the obligations of the
Company to make or pay, or cause to be made or paid, when due, all Loan Payments
with respect to any then outstanding Bonds which have been issued and delivered
pursuant to this Agreement, in the manner and under the terms and conditions
provided herein and in the Bond Resolution or

                                       26
<PAGE>

Indenture, or which would change or affect Article II, Sections 5.01, 5.03,
5.11, 6.01, 7.01, 7.02, 7.04, 7.05, 8.03, or 8.04 hereof or the provisions of
this sentence unless, in the judgment of the Trustee, such change or amendment
would not materially adversely affect the interests of the Bondholders or the
Credit Facility Issuer.

        Section 8.04. ASSIGNMENT. The Company may assign its interest in this
Agreement, in whole or in part, upon the written consent of the Credit Facility
Issuer, provided, however, no assignment, (other than pursuant to Section 7.02
hereof) shall relieve the Company from primary liability for any of its
obligations hereunder, and without limiting the generality of the foregoing, in
the event of any such assignment, the Company shall continue to remain primarily
liable for its payments specified herein and for performance and observance of
the other covenants and agreements on its part herein provided; and further
provided that no assignment shall be effective unless there is delivered a
Favorable Opinion with respect to such assignment. The Company shall, on or
prior to the effective date of any such assignment, furnish or cause to be
furnished to the Issuer, the Credit Facility Issuer and the Trustee notice of
such assignment, together with the referenced Favorable Opinion.

        Section 8.05. TERM OF AGREEMENT. The term of this Agreement shall be
from the date hereof until all payments and indemnities required to be made by
the Company pursuant hereto shall have been made.

        Section 8.06. NOTICES. Any notice, request or other communication under
this Agreement shall be given in writing and shall be deemed to have been given
by any person to any other person at the addresses shown below upon any of the
following dates:

               (a) The date of notice by telefax, telecopy, or similar
        telecommunications, which is confirmed promptly in writing;

               (b) Three (3) Business Days after the date of the mailing
        thereof, as shown by the post office receipt if mailed to the other
        party hereto by registered or certified mail;

               (c) The date of actual receipt thereof by such recipient if not
        given pursuant to (a) or (b) above.

        The addresses for any notices hereunder shall be as follows:

If to the Issuer:

Bastrop County Industrial Development Corporation
c/o County Judge's Office
804 Pecan
Bastrop, Texas 78602
Tel: (512) 303-2579
Fax: (512) 321-8800

If to the Company:

                                       27
<PAGE>

BioCrest Partners, L.P.
c/o Wayne S. Hollingsworth
Strasburger & Price, L.L.P.
2600 One American Center
Austin, Texas 78701
Tel: (512) 499-3600
Fax: (512) 499-3660

If to the Trustee:

First Bank National Association
c/o First Trust of California, National Association
One California Street, 4th Floor
San Francisco, California 94111
Tel: (415) 273-4515
Fax: (415) 273-4590

If to the Credit Facility Issuer:

Union Bank of California, N.A.
Commercial Banking
530 "B" Street, 4th Floor
San Diego, California 92101-4403
Attn: Steve Adkins

with a copy to:

Union Bank of California, N.A.
Credit Policy Administration
500 South Main Street, Suite 201
Orange, California 92868
Attn: Jack Lenhoff

If to the Remarketing Agent:

BT Securities
130 Liberty Street, 33rd Floor
New York, New York 10006
Attn: Kimberly Turner
Fax: (212) 250-7071

with a copy to:

                                       28
<PAGE>

Union Bank of California, N.A.
Bond Financing Department
445 S. Figueroa Street, 13th Floor
Los Angeles, California 90071
Attn: Norman S. Coker
Fax: (213) 629-5328

or the latest address specified by such other party in writing.

        Section 8.07. SEVERABILITY. If any clause, provision or Section of this
Agreement should be held illegal or invalid by any court, the invalidity of such
clause, provision or Section shall not affect any of the remaining clauses,
provisions or Sections hereof and this Agreement shall be construed and enforced
as if such illegal or invalid clause, provision or Section had not been
contained herein. In case any agreement or obligation contained in this
Agreement should be held to be in violation of law, then such agreement or
obligation shall be deemed to be the agreement or obligation of the Company or
the Issuer, as the case may be, to the full extent permitted by law.

        Section 8.08. EXECUTION OF COUNTERPARTS. This Agreement may be
simultaneously executed in several counterparts, each of which shall be an
original and all of which shall constitute but one and the same instrument.

        Section 8.09. GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED
EXCLUSIVELY BY AND CONSTRUED IN ACCORDANCE WITH THE APPLICABLE LAWS OF THE STATE
OF TEXAS. VENUE FOR ANY ACTIONS BROUGHT HEREUNDER TO WHICH THE ISSUER IS A PARTY
SHALL LIE IN BASTROP COUNTY, TEXAS.

        Section 8.10. NO PERSONAL LIABILITY. No covenant or agreement contained
in this Agreement shall be deemed to be the covenant or agreement of any
official, officer, agent, or employee of the Issuer or the Company in his or her
individual capacity, and no such person shall be subject to any personal
liability or accountability by reason of the issuance thereof.

        Section 8.11. FINAL AGREEMENT OF THE PARTIES. THIS AGREEMENT CONSTITUTES
A LOAN AGREEMENT FOR PURPOSES OF SECTION 26.02(a) OF THE TEXAS BUSINESS AND
COMMERCE CODE, AND REPRESENTS THE FINAL AGREEMENT BETWEEN THE PARTIES AND MAY
NOT BE CONTRADICTED BY EVIDENCE OF PRIOR, CONTEMPORANEOUS OR SUBSEQUENT ORAL
AGREEMENTS OF THE PARTIES. THERE ARE NO UNWRITTEN ORAL AGREEMENTS BETWEEN THE
PARTIES.

                                       29
<PAGE>

        IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
signed in multiple counterparts, each of which shall be considered an original
for all purposes, as of the day and year first set out above.

                                           BASTROP COUNTY INDUSTRIAL
                                           DEVELOPMENT CORPORATION

                                           BY /s/ MARK SHEFFIELD
                                              ----------------------------------
                                              President, Board of Directors

ATTEST:

/s/ [Signature Illegible]
--------------------------------------
Secretary, Board of Directors

(SEAL)

<PAGE>

                                           BIOCREST PARTNERS, L.P.,
                                           a Delaware Limited Partnership

                                           By: BioCrest Management, L.L.P.,
                                           a Delaware Limited Liability Company,
                                           General Partner

                                           By: /s/ JOSEPH A. SORGE
                                              ---------------------------------
                                           Name: Joseph A. Sorge, M.D.
                                           Title: Manager

<PAGE>

                                    EXHIBIT A

                               PROJECT DESCRIPTION

        The Project includes the acquisition of land and the construction and
equipment of a building to house a manufacturing facility up to approximately
72,000 square feet to manufacture products for scientific research and
diagnostics. The Project will be located on approximately 41 acres within the
McKinney Roughs site (John Little Survey A-228 and the J-M Survey A-5 Bastrop
County, Texas) at Pope Bend Road and Highway 71 in Bastrop, Texas.

                                      A-1
<PAGE>

                                    EXHIBIT B

STATEMENT NO. __ REQUESTING DISBURSEMENT OF FUNDS FROM CONSTRUCTION FUND
PURSUANT TO SECTION 3.03 OF THE LOAN AGREEMENT BETWEEN THE BASTROP COUNTY
INDUSTRIAL DEVELOPMENT CORPORATION AND BioCrest PARTNERS, L.P.

        Pursuant to Section 3.03 of the Loan Agreement (the "Agreement") between
the Bastrop County Industrial Revenue Corporation (the "Issuer") and BioCrest
Partners, L.P. (the "User") dated as of April 1, 1997, the undersigned
Authorized Company Representative hereby requests and authorizes __________, as
trustee (the "Trustee"), as depository of the Construction Fund created by the
Indenture, as defined in the Agreement, to pay to the company or to the
person(s) listed on the Disbursement Schedule attached hereto out of the moneys
on deposit in the Construction Fund the aggregate sum of $_____ , to pay such
person(s) or to reimburse the Company in full as indicated in the Disbursement
Schedule, for advances, payments and expenditures made by it in connection with
the items listed in the Disbursement Schedule.

        In connection with the foregoing request and authorization, the
undersigned hereby certifies that:

        (a) Each item for which disbursement is requested hereunder is properly
payable out of the Construction Fund in accordance with the terms and conditions
of the Agreement and none of those items has formed the basis for any
disbursement heretofore made from the Construction Fund;

        (b) Each such item is or was necessary in connection with the
acquisition, renovation, construction, equipping or installation of the property
comprising the Project, as defined in the Agreement;

        (c) This statement and all exhibits hereto, including the Disbursement
Schedule, shall be conclusive evidence of the facts and statements set forth
herein and shall constitute full warrant, protection and authority to the
Trustee for its actions taken pursuant hereto; and

        (d) This statement constitutes the approval of the Company of each
disbursement hereby requested and authorized.

        (e) At least ninety-five percent (95%) of the amounts withdrawn pursuant
to this statement, when added to amounts withdrawn previously, have been or will
be used for capitalizable costs of the Project.

        (f) The amounts withdrawn pursuant to this statement, when added to
amounts previously withdrawn, have not been or will not be used for the payment
of Costs of Issuance (whether or not payable as a discount) in excess of two
percent (2%) of the proceeds of the Bonds.

                                       B-1
<PAGE>

        IN WITNESS WHEREOF, the Authorized Company Representative has set his
hand as of the ________ day of ___________________ , 1997.

                                           _____________________________________
                                           Authorized Company Representative

                                           Approved by:

                                           Union Bank of California, N.A.

                                           By: _________________________________
                                           Title: ______________________________

                                      B-2

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