Document:

Exhibit
10.1

 

JOINDER
AND SECOND AMENDMENT TO 

AMENDED
AND RESTATED LOAN AND SECURITY agreement

 

This
Joinder and Second Amendment to Amended and Restated Loan and Security Agreement (this “Amendment”) is entered
into this 21st day of June, 2018 by and among (a) SILICON VALLEY BANK, a California corporation (“Bank”),
and (b) (i) CANCER GENETICS, INC., a Delaware corporation (“Parent”), (ii) GENTRIS, LLC, a Delaware
limited liability company (“Delaware Subsidiary” and together with Parent, individually and collectively, jointly
and severally, the “Existing Borrower”), (iii) VIVOPHARM, LLC, a Delaware limited liability company
(“Vivo”), and (iv) RDDT A VIVOPHARM COMPANY PTY LTD, a company incorporated under the laws of Australia (“Australian
Borrower”, and together with Vivo, jointly and severally, individually and collectively, “New Borrower”)
(Australian Borrower, together with Vivo and Existing Borrower, jointly and severally, individually and collectively, “Borrower”).

 

Recitals

 

A.
Bank and Existing Borrower have entered into that certain Amended and Restated Loan and Security Agreement dated as of March
22, 2017, as amended by that certain Waiver and First Amendment to Amended and Restated Loan and Security Agreement dated as of
May 14, 2018, between Existing Borrower and Bank (as the same may from time to time be further amended, modified, supplemented
or restated, the “Loan Agreement”).

 

B.
Bank has extended credit to Existing Borrower for the purposes permitted in the Loan Agreement.

 

C.
Existing Borrower has requested that Bank amend the Loan Agreement to (i) add new borrowers to the Loan Agreement and (ii)
make certain other revisions to the Loan Agreement as more fully set forth herein.

 

D.
In reliance upon the representations and warranties set forth below, Bank has agreed to so amend certain provisions of the
Loan Agreement, but only to the extent provided in this Amendment, and only in accordance with the terms and subject to the conditions
set forth below.

 

Agreement

 

Now,
Therefore, in consideration of the foregoing
recitals and other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, and intending to
be legally bound, the parties hereto agree as follows:

 

1.
Definitions.
Capitalized terms used but not defined in this Amendment shall have the meanings given to them in the Loan Agreement.

 

    	 

    	 

    

 

2.
Joinder to Loan Agreement. The
undersigned, Vivo and Australian Borrower, hereby join the Loan Agreement and each of the Loan Documents, as if each were originally
named a “Borrower” therein. Without limiting the generality of the preceding sentence, New Borrower agrees that it
will be jointly and severally liable, together with Existing Borrower, for the payment and performance of all obligations and
liabilities of Borrower under the Loan Agreement, including, without limitation, the Obligations. Each Borrower hereby appoints
the other as agent for the other for all purposes hereunder. Each Borrower hereunder shall be obligated to repay all Credit Extensions
made pursuant to the Loan Agreement, regardless of which Borrower actually receives said Credit Extension, as if each Borrower
hereunder directly received all Credit Extensions.

 

3.
Subrogation and Similar Rights.
Each Borrower waives any suretyship defenses available to it under the Code or any other applicable law. Each Borrower waives
any right to require Bank to: (i) proceed against any Borrower or any other person; (ii) proceed against or exhaust any security;
or (iii) pursue any other remedy. Bank may exercise or not exercise any right or remedy it has against any Borrower or any security
it holds (including the right to foreclose by judicial or non-judicial sale) without affecting any Borrower’s liability.
Notwithstanding any other provision of this Amendment, the Loan Agreement or other Loan Documents, each Borrower irrevocably waives
all rights that it may have at law or in equity (including, without limitation, any law subrogating Borrower to the rights of
Bank under the Loan Agreement) to seek contribution, indemnification or any other form of reimbursement from the other Borrowers,
or any other Person now or hereafter primarily or secondarily liable for any of the Obligations, for any payment made by Borrower
with respect to the Obligations in connection with the Loan Agreement or otherwise and all rights that it might have to benefit
from, or to participate in, any security for the Obligations as a result of any payment made by Borrower with respect to the Obligations
in connection with the Loan Agreement or otherwise. Any agreement providing for indemnification, reimbursement or any other arrangement
prohibited under this Section shall be null and void. If any payment is made to a Borrower in contravention of this Section, such
Borrower shall hold such payment in trust for Bank and such payment shall be promptly delivered to Bank for application to the
Obligations, whether matured or unmatured.

 

4.
Grant of Security Interest.
To secure the prompt payment and performance of all the Obligations, New Borrower hereby grants to Bank a continuing lien upon
and security interest in all of New Borrower’s now existing or hereafter arising rights and interest in the Collateral,
whether now owned or existing or hereafter created, acquired or arising, and wherever located, including, without limitation,
all of New Borrower’s assets (including, without limitation, its Intellectual Property), and all New Borrower’s books
relating to the foregoing and any and all claims, rights and interest in any of the above and all substitutions for, additions,
attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of any or
all of the foregoing. New Borrower further covenants and agrees that by its execution hereof it shall provide all such information,
complete all such forms, and take all such actions, and enter into all such agreements, in form and substance reasonably satisfactory
to Bank that are reasonably deemed necessary by Bank in order to grant a valid, perfected first priority security interest to
Bank in the Collateral. New Borrower hereby authorizes Bank to file financing statements, without notice to Borrower, with all
appropriate jurisdictions in order to perfect or protect Bank’s interest or rights hereunder, including a notice that any
disposition of the Collateral, by any Borrower or any other Person, shall be deemed to violate the rights of the Bank under the
Code.

 

    	 	2	 

    	 

    

 

5.
Representations and Warranties.
New Borrower hereby represents and warrants to Bank that all representations and warranties in the Loan Documents made on the
part of Existing Borrower are true and correct on the date hereof with respect to New Borrower, with the same force and effect
as if New Borrower were named as “Borrower” in the Loan Documents in addition to Existing Borrower.

 

6.
Delivery of Documents.
New Borrower hereby agrees that the following documents shall be delivered to the Bank prior to or contemporaneously with delivery
of this Amendment, each in form and substance satisfactory to the Bank:

 

	 	A.	the
    completed Borrowing Resolutions for Vivo, together with the duly executed original signatures thereto; 
	 	 	 
	 	B.
    	the
    Operating Documents and long-form good standing certificate of Vivo certified by the Secretary of State of Delaware and each
    jurisdiction in which Vivo is qualified to conduct business, each as of a date no earlier than thirty (30) days prior to the
    date hereof; 
	 	 	 
	 	C.
    	a
    certified copy of the Certificate of Registration and Constitution of each of Australian Borrower and Guarantor, as amended,
    a Verification Certificate containing a certified copy of extracts of meeting of the directors of each of Australian Borrower
    and Guarantor authorizing the execution of this Agreement and any other Loan Documents to which it is a party;
	 	 	 
	 	D.
    	a
    landlord’s consent in favor of Bank for 1214 Research Boulevard, Hummelstown, Pennsylvania 17036 by the landlord thereof,
    together with the duly executed original signatures thereto;
	 	 	 
	 	E.
    	duly
    executed original signatures to the Australian Security and Guarantee required by Bank;
	 	 	 
	 	F.
    	the
    duly executed blank share transfer form and original share certificate for the issued shares in Australian Borrower;
	 	 	 
	 	G.
    	certified
    copies, dated as of a recent date, of financing statement searches, as Bank may request, accompanied by written evidence (including
    any UCC and PPSR termination statements) that the Liens indicated in any such financing statements either constitute Permitted
    Liens or have been terminated or released; 
	 	 	 
	 	H.
    	an
    Intellectual Property Security Agreement of each New Borrower and Guarantor, together with the duly executed original signature
    thereto (collectively, the “New Borrower IP Security Agreement”)
	 	 	 
	 	I.
    	a
    Perfection Certificate of each New Borrower, together with the duly executed original signatures thereto (collectively, the
    “New Borrower Perfection Certificate”); 

 

    	 	3	 

    	 

    

 

	 	J.
    	a
    Perfection Certificate of Guarantor, together with the duly executed original signatures thereto;
	 	 	 
	 	K.
    	legal
    opinion of Bank’s Australian counsel in respect of Australian Borrower and Guarantor (authority/enforceability), in
    form and substance acceptable to Bank;
	 	 	 
	 	L.
    	evidence
    satisfactory to Bank that the insurance policies and endorsements required by the Loan Agreement are in full force and effect,
    together with appropriate evidence showing lender loss payable and/or additional insured clauses or endorsements in favor
    of Bank; and
	 	 	 
	 	M.
    	such
    other documents as Bank may reasonably request.

 

7.
Amendments to Loan Agreement.

 

7.1
Section 1 (Accounting and Other Terms). Section 1 is amended in its entirety and replaced with the following:

 

“
Accounting terms not defined in this Agreement shall be construed following GAAP. Calculations and determinations must be made
following GAAP. Notwithstanding any terms in this Agreement to the contrary, for purposes of any financial covenant and other
financial calculations in this Agreement (other than for purposes of updating the Borrowing Base) which are made in whole or in
part based upon the Availability Amount as of the last day of a particular month, calculations relying on information from a Borrowing
Base Report shall be derived from the Borrowing Base Report delivered within seven (7) days of month end pursuant to Section 6.2(a)
(and not, for clarity, any more recent Borrowing Base Report delivered after such period), and the actual delivery date of such
Borrowing Base Report shall be deemed to be the last day of the applicable month. Capitalized terms not otherwise defined in this
Agreement shall have the meanings set forth in Section 13. All other terms contained in this Agreement, unless otherwise indicated,
shall have the meaning provided by the Code to the extent such terms are defined therein.”

 

7.2
Section 2.3 (Overadvances). Section 2.3 is amended in its entirety and replaced with the following:

 

“
Section 2.3 Overadvances. If, at any time, the sum of (a) the outstanding principal amount of any Advances, plus, commencing
upon the occurrence of the Second Equity Event, (b) the face amount of any outstanding Letters of Credit (including drawn but
unreimbursed Letters of Credit and any Letter of Credit Reserve) exceeds the lesser of either the Revolving Line or the Borrowing
Base, Borrower shall immediately pay to Bank in cash the amount of such excess (such excess, the “Overadvance”).
Without limiting Borrower’s obligation to repay Bank any Overadvance, Borrower agrees to pay Bank interest on the outstanding
amount of any Overadvance, on demand, at the Default Rate.”

 

    	 	4	 

    	 

    

 

7.3
Section 2.8 (Letters of Credit Sublimit). The Loan Agreement is amended by inserting the following new provision to appear
as Section 2.8 thereof:

 

“
2.8 Letters of Credit Sublimit.

 

(a)
Commencing upon the occurrence of the Second Equity Event, as part of the Revolving Line, Bank shall issue or have issued Letters
of Credit denominated in Dollars or a Foreign Currency for Borrower’s account. The aggregate Dollar Equivalent amount utilized
for the issuance of Letters of Credit shall at all times reduce the amount otherwise available for Advances under the Revolving
Line. The aggregate Dollar Equivalent of the face amount of outstanding Letters of Credit (including drawn but unreimbursed Letters
of Credit and any Letter of Credit Reserve) may not exceed the lesser of (i) Three Hundred Fifty Thousand Dollars ($350,000.00)
or (ii) (A) the lesser of (x) the Revolving Line or (y) the Borrowing Base, minus (B) the sum of all outstanding principal amounts
of any Advances (including the aggregate Dollar Equivalent of the face amount of outstanding Letters of Credit (including drawn
but unreimbursed Letters of Credit and any Letter of Credit Reserve)).

 

(b)
If, on the Revolving Line Maturity Date (or the effective date of any termination of this Agreement), there are any outstanding
Letters of Credit, then on such date Borrower shall provide to Bank cash collateral in an amount equal to at least one hundred
five percent (105.0%) for Letters of Credit denominated in Dollars or at least one hundred ten percent (110.0%) for Letters of
Credit denominated in a Foreign Currency, in each case of the aggregate Dollar Equivalent of the face amount of all such Letters
of Credit plus all interest, fees, and costs due or estimated by Bank to become due in connection therewith, to secure all of
the Obligations relating to such Letters of Credit. All Letters of Credit shall be in form and substance acceptable to Bank in
its sole discretion and shall be subject to the terms and conditions of Bank’s standard Application and Letter of Credit
Agreement (the “Letter of Credit Application”). Borrower agrees to execute any further documentation in connection
with the Letters of Credit as Bank may reasonably request. Borrower further agrees to be bound by the regulations and interpretations
of the issuer of any Letters of Credit guarantied by Bank and opened for Borrower’s account or by Bank’s interpretations
of any Letter of Credit issued by Bank for Borrower’s account, and Borrower understands and agrees that Bank shall not be
liable for any error, negligence, or mistake, whether of omission or commission, in following Borrower’s instructions or
those contained in the Letters of Credit or any modifications, amendments, or supplements thereto.

 

(c)
The obligation of Borrower to immediately reimburse Bank for drawings made under Letters of Credit shall be absolute, unconditional,
and irrevocable, and shall be performed strictly in accordance with the terms of this Agreement, such Letters of Credit, and the
Letter of Credit Application.

 

    	 	5	 

    	 

    

 

(d)
Borrower may request that Bank issue a Letter of Credit payable in a Foreign Currency. If a demand for payment is made under any
such Letter of Credit, Bank shall treat such demand as an Advance to Borrower of the Dollar Equivalent of the amount thereof (plus
fees and charges in connection therewith such as wire, cable, SWIFT or similar charges).

 

(e)
To guard against fluctuations in currency exchange rates, upon the issuance of any Letter of Credit payable in a Foreign Currency,
Bank shall create a reserve (the “Letter of Credit Reserve”) under the Revolving Line in an amount equal to
a percentage (which percentage shall be determined by Bank in its sole discretion). The amount of the Letter of Credit Reserve
may be adjusted by Bank from time to time to account for fluctuations in the exchange rate. The availability of funds under the
Revolving Line shall be reduced by the amount of such Letter of Credit Reserve for as long as such Letter of Credit remains outstanding.”

 

7.4
Section 2.5 (Fees). Subsection (c)(ii) of Section 2.5 is amended in its entirety and replaced with the following:

 

“
(ii) the average for the period of the daily closing balance of the Revolving Line outstanding plus, commencing upon the occurrence
of the Second Equity Event, the sum of the aggregate Dollar Equivalent amount of outstanding Letters of Credit (including drawn
but unreimbursed Letters of Credit and any Letter of Credit Reserve);”

 

7.5
Section 2.5 (Fees). Section 2.5 is amended by (i) replacing “; and” with “;” at the end of subsection
(c), (ii) replacing “.” with “; and” at the end of subsection (d), and (iii) inserting the following text
to appear as subsection (e) thereof:

 

“
(e) Letter of Credit Fee. Bank’s customary fees and expenses for the issuance or renewal of Letters of Credit, upon
the issuance of such Letter of Credit, each anniversary of the issuance during the term of such Letter of Credit, and upon the
renewal of such Letter of Credit by Bank.”

 

7.6
Section 2.6(b) (Payments; Application of Payments; Debit of Accounts). Section 2.6(b) is amended by deleting the text “this
Agreement” appearing therein and inserting in lieu thereof the text “the Loan Documents”.

 

7.7
Section 2.7 (Withholding). Section 2.7 is amended by deleting the text “this Agreement” appearing therein and
inserting in lieu thereof the text “the Loan Documents”.

 

7.8
Section 3.2(b) (Conditions Precedent to all Credit Extensions). Section 3.2(b) is amended in its entirety and replaced with
the following:

 

    	 	6	 

    	 

    

 

“
(b) the representations and warranties in this Agreement and the Australian Security and Guarantee shall be true, accurate, and
complete in all material respects on the date of the proposed Credit Extension, and on the Funding Date of each Credit Extension;
provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already
are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties
expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date, and no Event
of Default shall have occurred and be continuing or result from the Credit Extension. Each Credit Extension is Borrower’s
representation and warranty on that date that the representations and warranties in this Agreement and the Australian Security
and Guarantee remain true, accurate, and complete in all material respects; provided, however, that such materiality qualifier
shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text
thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true,
accurate and complete in all material respects as of such date; and”

 

7.9
Section 3.4 (Conditions Precedent to all Credit Extensions). Section 3.2(b) is amended in its entirety and replaced with the
following:

 

“Section
3.4 Procedures for Borrowing. Subject to the prior satisfaction of all other applicable conditions to the making of an Advance
set forth in this Agreement, to obtain an Advance, Borrower (via an individual duly authorized by an Administrator) shall notify
Bank (which notice shall be irrevocable) by electronic mail by 2:00 p.m. Eastern time on the Funding Date of the Advance. Such
notice shall be made by Borrower through Bank’s online banking program, provided, however, if Borrower is not utilizing
Bank’s online banking program, then such notice shall be in a written format reasonably acceptable to Bank that is executed
by an Authorized Signer. Bank shall have received satisfactory evidence that the Board has approved that such Authorized Signer
may provide such notices and request Advances. In connection with any such notification, Borrower must promptly deliver to Bank
by electronic mail or through Bank’s online banking program such reports and information, including without limitation,
a Borrowing Base Report, sales journals, cash receipts journals, accounts receivable aging reports, as Bank may request in its
sole discretion. Bank shall credit proceeds of an Advance to the Designated Deposit Account. Bank may make Advances under this
Agreement based on instructions from an Authorized Signer or without instructions if the Advances are necessary to meet Obligations
which have become due.”

 

7.10
Section 4.1 (Grant of Security Interest). Section 4.1 is amended in its entirety and replaced with the following:

 

“4.1
Grant of Security Interest. Borrower hereby grants Bank, to secure the payment and performance in full of all of the Obligations,
a continuing security interest in, and pledges to Bank, the Collateral, wherever located, whether now owned or hereafter acquired
or arising, and all proceeds and products thereof.

 

    	 	7	 

    	 

    

 

All
Obligations shall be also be secured by the Australian Security and Guarantee and any and all other security agreements, mortgages
or other collateral granted to Bank by Australian Borrower as security for the Obligations, now or in the future.

 

Borrower
acknowledges that it previously has entered, and/or may in the future enter, into Bank Services Agreements with Bank. Regardless
of the terms of any Bank Services Agreement, Borrower agrees that any amounts Borrower owes Bank thereunder shall be deemed to
be Obligations hereunder and that it is the intent of Borrower and Bank to have all such Obligations secured by the first priority
perfected security interest in the Collateral granted herein and in the Australian Security and Guarantee or other collateral
granted to Bank by Australian Borrower as security for the Obligations, now or in the future (subject only to Permitted Liens
that are permitted pursuant to the terms of this Agreement to have superior priority to Bank’s Lien in this Agreement).

 

If
this Agreement is terminated, Bank’s Lien in the Collateral shall continue until the Obligations (other than inchoate indemnity
obligations) are repaid in full in cash. Upon payment in full in cash of the Obligations (other than inchoate indemnity obligations)
and at such time as Bank’s obligation to make Credit Extensions has terminated, Bank shall, at the sole cost and expense
of Borrower, release its Liens in the Collateral and all rights therein shall revert to Borrower. In the event (x) all Obligations
(other than inchoate indemnity obligations), except for Bank Services, are satisfied in full, and (y) this Agreement and the Australian
Security and Guarantee is terminated, Bank shall terminate the security interest granted herein and in the Australian Security
and Guarantee upon Borrower providing cash collateral acceptable to Bank in its good faith business judgment for Bank Services,
if any. In the event such Bank Services consist of outstanding Letters of Credit, Borrower shall provide to Bank cash collateral
in an amount equal to (x) if such Letters of Credit are denominated in Dollars, then at least one hundred five percent (105.0%);
and (y) if such Letters of Credit are denominated in a Foreign Currency, then at least one hundred ten percent (110.0%), of the
Dollar Equivalent of the face amount of all such Letters of Credit plus all interest, fees, and costs due or to become due in
connection therewith (as estimated by Bank in its business judgment), to secure all of the Obligations relating to such Letters
of Credit.”

 

7.11
Section 4.2 (Priority of Security Interest). Section 4.2 is amended by replacing the first sentence thereof with the following
text:

 

“Borrower
represents, warrants, and covenants that the security interest granted herein and in the Australian Security and Guarantee is
and shall at all times continue to be a first priority perfected security interest in the Collateral (subject only to Permitted
Liens that are permitted pursuant to the terms of this Agreement to have superior priority to Bank’s Lien under this Agreement).”

 

7.12
Section 5.1 (Due Organization, Authorization; Power and Authority). Section 5.1 is amended by inserting the following new
text, to appear at the end of the first paragraph thereof:

 

    	 	8	 

    	 

    

 

“Australian
Borrower is a proprietary company, duly registered and validly existing under the laws of Australia and has the power to carry
on its business as it is now being conducted and to own its property and other assets.”

 

7.13
Section 5.2 (Collateral). Section 5.2 is amended by replacing the first sentence thereof with the following text:

 

“Borrower
has good title to, rights in, and the power to transfer each item of the Collateral upon which it purports to grant a Lien hereunder
or the Australian Security and Guarantee, free and clear of any and all Liens except Permitted Liens.”

 

7.14
Section 5.9 (Tax Returns and Payments; Pension Contributions). Section 5.9 is amended by replacing the first paragraph thereof
with the following text:

 

“Borrower
has timely filed all required tax returns and reports, and Borrower has timely paid all Taxes, Australian, foreign, federal, state
and local taxes, assessments, deposits and contributions owed by Borrower except (a) to the extent such taxes are being contested
in good faith by appropriate proceedings promptly instituted and diligently conducted, so long as such reserve or other appropriate
provision, if any, as shall be required in conformity with GAAP shall have been made therefor, or (b) if such taxes, assessments,
deposits and contributions do not, individually or in the aggregate, exceed Twenty-Five Thousand Dollars ($25,000.00).”

 

7.15
Section 5.13 (Taxation). The Loan Agreement is amended by inserting the following text to appear as Section 5.13 (Taxation)
thereof:

 

“5.13
Taxation. Borrower has complied in all material respects with all Taxation laws in all jurisdictions in which it is subject
to Taxation and has paid all Taxes due and payable by it and no claims are being asserted against it in respect of Taxes save
for assessments in relation to the ordinary course of the business of Borrower or claims contested in good faith and in respect
of which adequate provision has been made and disclosed in the latest accounts of Borrower or information delivered to Bank under
this Agreement.”

 

7.16
Section 6.2(a) (Financial Statements, Reports, Certificates). Section 6.2(a) is amended in its entirety and replaced with
the following:

 

“
(a) a Borrowing Base Report (and any schedules related thereto and including any other information requested by Bank with respect
to Borrower’s Accounts) (i) with each Advance request and (ii) within seven (7) days after the end of each month;”

 

7.17
Section 6.2(k) (Financial Statement, Reports, Certificates). Section 6.2 is hereby amended by (i) deleting “; and”
in subsection (i) and replacing it with “;”, (ii) deleting “.” in subsection (j) and replacing it with
“;”, and (ii) inserting the following to appear as subsections (k) and (l) thereto:

 

    	 	9	 

    	 

    

 

“
(k) prior to the occurrence of the Second Equity Event, no later than Friday of each week, a thirteen (13) week cash flow forecast,
in a form acceptable to Bank; and

 

(l)
prompt written notice of any changes to the beneficial ownership information set out in items 2(d) and 2(e) of the Perfection
Certificate. Borrower understands and acknowledges that Bank relies on such true, accurate and up-to-date beneficial ownership
information to meet Bank’s regulatory obligations to obtain, verify and record information about the beneficial owners of
its legal entity customers.”

 

7.18
Section 6.6 (Access to Collateral; Books and Records). The last sentence of Section 6.6 is amended in its entirety and replaced
with the following:

 

“In
the event Borrower and Bank schedule an audit more than eight (8) days in advance, and Borrower cancels or seeks to or reschedules
the audit with less than eight (8) days written notice to Bank, then (without limiting any of Bank’s rights or remedies)
Borrower shall pay Bank a fee of Two Thousand Dollars ($2,000.00) plus any out-of-pocket expenses incurred by Bank to compensate
Bank for the anticipated costs and expenses of the cancellation or rescheduling.”

 

7.19
Section 6.8(a) (Accounts). Section 6.8(a) is amended in its entirety and replaced with the following:

 

“
(a) Maintain all of its, all of its Subsidiaries’ and all of Australian Parent’s operating and other depository accounts,
the Cash Collateral Account and securities/investment accounts with Bank and Bank’s Affiliates; provided, however, during
the Transition Period, Borrower shall be permitted to maintain (i) lockbox accounts with JP Morgan Chase Bank (the “Chase
Accounts”) provided that Borrower shall transfer any and all funds maintained or deposited into the Chase Accounts into
an account of Borrower maintained with Bank on a bi-weekly basis and (ii) one (1) account with Regions Bank, provided that the
maximum balance in the Regions Account shall not at any time exceed Ten Thousand Dollars ($10,000.00) (the “Regions Account”
and collectively with the Chase Accounts, the “Temporary Accounts”). Notwithstanding the foregoing, the Borrower
shall be permitted to maintain certificates of deposit with JP Morgan Chase Bank to secure Borrower’s letter of credit with
JP Morgan Chase Bank maintained as a security deposit for Borrower’s lease of its headquarters premises, provided that the
aggregate balance maintained in such certificates of deposit does not at any time exceed Three Hundred Six Thousand Dollars ($306,000.00)
plus accrued interest (collectively, the “CD Accounts”). In addition, (i) during the PNC Transition Period,
Vivo shall be permitted to maintain one (1) account with PNC Bank, provided that the maximum balance in the PNC Account shall
not at any time exceed Two Hundred Thousand Dollars ($200,000.00) (the “PNC Account”) and (ii) Australian Parent
shall be permitted to maintain (A) two (2) accounts (account nos. 531 and 854) with Westpac Australia provided that the maximum
balance in account no. 531 shall not at any time exceed Four Hundred Thousand Australian Dollars (AUD$400,000.00) and the maximum
balance in account no. 854 shall not at any time exceed Twenty-Five Thousand Australian Dollars (AUD$25,000.00) (collectively,
the “Westpac Accounts”), and (B) one (1) payment transmitter account with Cambridge Mercantile (Australia)
Pty. Ltd. Any Guarantor shall maintain all depository, operating and securities/investment accounts with Bank and Bank’s
Affiliates. In addition, Borrower and any Guarantor shall use Bank for all foreign exchange and letters of credit.”

 

    	 	10	 

    	 

    

 

7.20
Section 6.8(b) (Accounts). The last sentence of Section 6.8(b) is amended in its entirety and replaced with the following:

 

“The
provisions of the previous sentence shall not apply to (i) the CD Accounts, (ii) the Temporary Accounts during the Transition
Period, (iii) the PNC Account during the PNC Transition Period, (iv) the Westpac Accounts, or (v) deposit accounts exclusively
used for payroll, payroll taxes and other employee wage and benefit payments to or for the benefit of Borrower’s employees
and identified to Bank by Borrower as such.”

 

7.21
Section 6.9 (Financial Covenants). Section 6.9 is amended in its entirety and replaced with the following:

 

“6.9
Financial Covenants.

 

(a)
Adjusted EBITDA. Achieve, to be tested as of the last day of each month, calculated on a consolidated basis with respect
to Borrower and its Subsidiaries, measured on a trailing three (3) month basis, Adjusted EBITDA, for the period indicated in accordance
with the following schedule, of at least:

 

	Three (3) Month Period Ending	 	 	Adjusted EBITDA	 
	 	March 31, 2018	 	 	$	(3,300,000	)
	 	April 30, 2018	 	 	$	(2,850,000	)
	 	May 31, 2018	 	 	$	(2,500,000	)
	 	June 30, 2018	 	 	$	(2,000,000	)
	 	July 31, 2018	 	 	$	(1,800,000	)
	 	August 31, 2018	 	 	$	(1,650,000	)
	 	September 30, 2018	 	 	$	(1,500,000	)
	 	October 31, 2018	 	 	$	(750,000	)
	 	November 30, 2018	 	 	$	0.00	 
	 	December 31, 2018 and each period thereafter	 	 	$	750,000	 

 

    	 	11	 

    	 

    

 

(b)
Minimum Revenue. Achieve, to be tested as of the last day of each quarter, calculated on a consolidated basis with respect
to Borrower and its Subsidiaries, revenue for each fiscal quarter, for the period indicated in accordance with the following schedule,
of at least:

 

	Quarter	 	 	Minimum Revenue	 
	 	March 31, 2018	 	 	$	6,300,000	 
	 	June 30, 2018	 	 	$	7,010,000	 
	 	September 30, 2018	 	 	$	7,042,000	 
	 	December 31, 2018	 	 	$	7,830,000	 

 

With
respect to the period ending March 31, 2019 and each period thereafter, the levels of minimum revenue shall be set by Bank in
its sole discretion, based upon Borrower’s Board-approved operating plan and financial projections, which covenant levels
shall be set at an amount equal to at least one hundred percent (100.0%) of the corresponding levels of minimum revenue set forth
for such periods for Borrower’s prior fiscal year. With respect thereto, (i) Borrower’s failure to either (1) agree
in writing (which agreement shall be set forth in a written amendment to this Agreement) on or before February 15, 2019, to any
such covenant levels with respect to Borrower’s fiscal year ending December 31, 2019, or (2) notwithstanding Section 6.2(e)
of this Agreement, deliver to Bank, on or before the earlier to occur of (i) January 31, 2019 or (ii) approval by the Board, Borrower’s
budgets, sales projections, operating plans and other financial information of Borrower that Bank deems relevant, including, without
limitation, Borrower’s Board-approved operating budgets, projections and plans, with respect to Borrower’s fiscal
year ending December 31, 2019, shall result in an immediate Event of Default for which there shall be no grace or cure period.

 

(c)
Minimum Liquidity. Maintain at all times, to be tested as of the last day of each month, Liquidity of at least Two Million
Dollars ($2,000,000.00).”

 

7.22
Section 6.10(b) (Protection and Registration of Intellectual Property Rights). Section 6.10(b) is amended by replacing the
second sentence thereof with the following text:

 

“If
Borrower decides to register any Copyrights or mask works in the United States Copyright Office or the Personal Properties Securities
Register thereof, Borrower shall: (x) provide Bank with at least fifteen (15) days prior written notice of Borrower’s intent
to register such Copyrights or mask works together with a copy of the application it intends to file with the United States Copyright
Office or the Australian equivalent thereof (excluding exhibits thereto); (y) execute an intellectual property security agreement
and such other documents and take such other actions as Bank may request in its good faith business judgment to perfect and maintain
a first priority perfected security interest in favor of Bank in the Copyrights or mask works intended to be registered with the
United States Copyright Office or the Australian equivalent thereof; and (z) record such intellectual property security agreement
with the United States Copyright Office or the Australian equivalent thereof contemporaneously with filing the Copyright or mask
work application(s) with the United States Copyright Office or the Australian equivalent thereof.”

 

    	 	12	 

    	 

    

 

7.23
Section 6.12 (Online Banking). Section 6.12 is amended in its entirety and replaced with the following:

 

“6.12
Online Banking.

 

(a)
Utilize Bank’s online banking platform for all matters requested by Bank which shall include, without limitation (and without
request by Bank for the following matters), uploading information pertaining to Accounts and Account Debtors, requesting approval
for exceptions, requesting Credit Extensions, and uploading financial statements and other reports required to be delivered by
this Agreement (including, without limitation, those described in Section 6.2 of this Agreement).

 

(b)
Comply with the terms of Bank’s Online Banking Agreement as in effect from time to time and ensure that all persons utilizing
Bank’s online banking platform are duly authorized to do so by an Administrator. Bank shall be entitled to assume the authenticity,
accuracy and completeness on any information, instruction or request for a Credit Extension submitted via Bank’s online
banking platform and to further assume that any submissions or requests made via Bank’s online banking platform have been
duly authorized by an Administrator.”

 

7.24
Section 6.13 (Further Assurances). Section 6.13 is amended by deleting the text “this Agreement” appearing therein
and inserting in lieu thereof the text “the Loan Documents”.

 

7.25
Section 7.2 (Changes in Business, Management, Control, or Business Locations). Section 7.2 is amended by inserting the following
text to appear as the last sentence thereof:

 

“If
Borrower intends to add any new offices or business locations, including warehouses, containing in excess of Ten Thousand Dollars
($10,000.00) of Borrower’s assets or property, then Borrower will first receive the written consent of Bank, and the landlord
of any such new offices or business locations, including warehouses, shall execute and deliver a landlord consent in form and
substance satisfactory to Bank.”

 

7.26
Section 7.5 (Encumbrance). Section 7.5 is amended in its entirety and replaced with the following:

 

“7.5
Encumbrance. Create, incur, allow, or suffer any Lien on any of its property, or assign or convey any right to receive income,
including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for Permitted Liens, permit any Collateral
not to be subject to the first priority security interest granted herein or in the Australian Security and Guarantee, or enter
into any agreement, document, instrument or other arrangement (except with or in favor of Bank) with any Person which directly
or indirectly prohibits or has the effect of prohibiting Borrower or any Subsidiary from assigning, mortgaging, pledging, granting
a security interest in or upon, or encumbering any of Borrower’s or any Subsidiary’s Intellectual Property, except
as is otherwise permitted in Section 7.1 hereof and the definition of “Permitted Liens” herein.”

 

    	 	13	 

    	 

    

 

7.27
Section 7.7 (Distributions; Investments). Section 7.7 is amended by inserting “or by Borrower to a Subsidiary which
is a Borrower.” to appear at the end of subsection (b) thereof.

 

7.28
Section 8 (Events of Default). Section 8 is amended by replacing the opening sentence thereof with the following text:

 

“Any
one of the following shall constitute an event of default (an “Event of Default”) under this Agreement and
the Loan Documents:”

 

7.29
Section 8.5 (Insolvency). Section 8.5 is amended in its entirety and replaced with the following:

 

“8.5
Insolvency. If any of the following occurs in respect of Borrower or any Subsidiary: (a) it is, or is deemed for the purposes
of any law to be, unable to pay its debts (including trade debts) as they become due or otherwise becomes insolvent; (b) it admits
its inability to pay its debts as they fall due; (c) it suspends making payments on any of its debts or announces an intention
to do so; (d) a moratorium is declared in respect of any of Borrower’s or any Subsidiary’s indebtedness; (e) by reason
of actual or anticipated inability to pay debts as they fall due or insolvency it begins negotiations with any creditor for the
rescheduling of any of its indebtedness; (f) the value of its assets is less than its liabilities (taking into account its prospective
and contingent liabilities); or (g) in respect of Australian Borrower, without limiting any of the foregoing: (i) it is taken
to have failed to comply with a statutory demand under section 459(F)(1) of the Corporations Act; (ii) it must be presumed by
a court to be insolvent under section 459(C)(2) of the Corporations Act; (iii) it is the subject of a circumstance specified in
section 461 of the Corporations Act (whether or not an application to court has been made under that section); (iv) if it is a
trustee of a trust, it is unable to satisfy out of the assets of the trust the liabilities incurred by it for which it has a right
to be indemnified from the assets of the trust as and when those liabilities fall due; or (v) it stops or suspends payment to
all or a class of creditors generally;”

 

7.30
Section 8.13 (Insolvency Proceedings). The Loan Agreement is amended by (i) replacing “; or” with “;”
at the end of Section 8.11 thereof, (ii) replacing “.” with “; or” at the end of Section 8.12 thereof,
and (iii) inserting the following text to appear as Section 8.13 (Insolvency Proceedings) thereof:

 

“8.13
Insolvency Proceedings. If any of the following occurs in respect of Borrower or any Subsidiary (each of which shall be an
“Insolvency Proceeding”): (a) Borrower or any Subsidiary begins a US Insolvency Proceeding or an Australian
Insolvency Proceeding; (b) a US Insolvency Proceeding is begun against Borrower or any Subsidiary and not dismissed or stayed
within forty-five (45) days (but no Credit Extensions shall be made until any US Insolvency Proceeding is dismissed); or (c) an
Australian Insolvency Proceeding is begun against Borrower and, to the extent that Borrower satisfies Bank that it is a vexatious
or frivolous winding-up petition, it not dismissed or stayed within fourteen (14) days (but no Credit Extensions shall be made
until any such Australian Insolvency Proceeding is dismissed);”

 

    	 	14	 

    	 

    

 

7.31
Section 9.6 (No Waiver; Remedies Cumulative). Section 9.6 is amended by replacing the penultimate sentence thereof with the
following text:

 

“Bank
has all rights and remedies provided under the Code, by law, or in equity. Bank’s exercise of one right or remedy is not
an election and shall not preclude Bank from exercising any other remedy under this Agreement or any other Loan Document or other
remedy available at law or in equity, and Bank’s waiver of any Event of Default is not a continuing waiver.”

 

7.32
Section 9.8 (Borrower Liability). Section 9.8 is amended by replacing the first and second sentence thereof with the following
text:

 

“Each
Borrower may, acting singly, request Credit Extensions hereunder. Each Borrower hereby appoints the others as agent for itself
for all purposes hereunder, including with respect to requesting Credit Extensions hereunder”

 

7.33
Section 11 (Choice of Law, venue and jury trial waiver). Section 11 is amended by deleting the text “this Agreement”
appearing in the first sentence thereof and inserting in lieu thereof the text “the Loan Documents”.

 

7.34
Section 12.1 (Termination Prior to Revolving Line Maturity Date; Survival). Section 12.1 is amended by replacing the first
sentence thereof with the following text:

 

“All
covenants, representations and warranties made in the Loan Documents shall continue in full force until the Loan Documents have
terminated pursuant to their terms and all Obligations have been satisfied.”

 

7.35
Section 12.4 (Time of Essence). Section 12.4 is amended in its entirety and replaced with the following:

 

“12.4
Time of Essence. Time is of the essence for the performance of all Obligations in the Loan Documents.”

 

7.36
Section 12.9 (Confidentiality). The last paragraph of Section 12.9 is amended in its entirety and replaced with the following:

 

“Bank
Entities may use anonymous forms of confidential information for aggregate datasets, for analyses or reporting, and for any other
uses not expressly prohibited in writing by Borrower. The provisions of the immediately preceding sentence shall survive the termination
of this Agreement.”

 

7.37
Section 12.11 (Right of Setoff). Section 12.11 is amended by inserting the following text to appear as the last paragraph
thereof:

 

    	 	15	 

    	 

    

 

“Bank
may, without any demand or notice, set off and apply indebtedness it owes to Australian Borrower against any money owing to it
by Australian Borrower under any Loan Document, whether or not the amount owed by Bank or Australian Borrower is immediately payable
or is owed alone or with any other person and, regardless of the place of payment, banking branch or currency of either obligation.
Further, Australian Borrower authorises Bank to apply (without prior notice) any credit balance (whether or not then due) to which
Australian Borrower is at any time beneficially entitled on any account at, any sum held to its order by and/or any liability
or obligation (whether or not matured) of, any office of Bank in or towards satisfaction of any sum then due and payable by it
to Bank under the Loan Documents and unpaid. For these purposes, Bank may convert one currency into another, provided that nothing
in this Section 12.11 shall be effective to create a charge.”

 

7.38
Section 12.17 (Conflicts). The Loan Agreement is amended by inserting the following text to appear as Section 12.17 (Conflicts)
thereof:

 

“12.17
Conflicts. In the event of any conflict between the terms of this Agreement and the terms of any Loan Document (other than
the Australian Security and Guarantee), the terms of this Agreement shall prevail. In no event will any representation, warranty
or covenant in any Loan Document (other than the Australian Security and Guarantee) prohibit or cause Borrower to take any additional
action or refrain from taking any action not required by this Agreement if and to the extent that the subject matter of the representation,
warranty or covenant in the Loan Document (other than the Australian Security and Guarantee) is dealt with in this Agreement.
Any representation, warranty or covenant in this Agreement which states that Bank shall not unreasonably withhold consent shall
apply to the counterpart representation, warranty or covenant in any Loan Document (other than the Australian Security and Guarantee)
(even if not specifically stated) and the parties agree that the representations, warranties and covenants in each of the Loan
Documents (other than the Australian Security and Guarantee) are not intended to be more restrictive than the counterpart representation,
warranty or covenant in this Agreement.”

 

7.39
Section 13 (Definitions). The preamble in the definition of Eligible Accounts set forth in Section 13.1 is deleted in its
entirety and replaced with the following:

 

“
“Eligible Accounts” means Accounts owing to Borrower which arise in the ordinary course of Borrower’s
business that meet all Borrower’s representations and warranties in Section 5.3, that have been, at the option of Bank,
confirmed in accordance with Section 6.3(f) of this Agreement, and are due and owing from Account Debtors deemed creditworthy
by Bank in its sole discretion. Bank reserves the right, at any time after the Effective Date, in its sole discretion in each
instance, to either (i) adjust any of the criteria set forth below and to establish new criteria or (ii) deem any Accounts owing
from a particular Account Debtor or Account Debtors to not meet the criteria to be Eligible Accounts. Unless Bank otherwise agrees
in writing, Eligible Accounts shall not include:”

 

    	 	16	 

    	 

    

 

7.40
Section 13 (Definitions). Subsection (a) of the definition of Eligible Accounts set forth in Section 13.1 is deleted
in its entirety and replaced with the following:

 

“
(a) Accounts (i) for which the Account Debtor is Borrower’s Affiliate, officer, employee, investor, or agent, or (ii) that
are intercompany Accounts;”

 

7.41
Section 13 (Definitions). Subsection (e) of the definition of Eligible Accounts set forth in Section 13.1 is deleted
in its entirety and replaced with the following:

 

“
(e) Accounts owing from an Account Debtor (i) which does not have its principal place of business in the United States or Canada
or (ii) whose billing address (as set forth in the applicable invoice for such Account) is not in the United States or Canada
(except in the case of both (i) and (ii) for Eligible Foreign Accounts, provided that the aggregate amount of Eligible Foreign
Accounts included in the Borrowing Base shall not exceed an amount equal to twenty-five percent (25.0%) of all amounts included
in the Borrowing Base at any time);”

 

7.42
Section 13 (Definitions). Subsection (t) of the definition of Eligible Accounts set forth in Section 13.1 is deleted
in its entirety and replaced with the following:

 

“(t)
Accounts in which the Account Debtor disputes liability or makes any claim (but only up to the disputed or claimed amount), or
if the Account Debtor is subject to an Insolvency Proceeding (whether voluntary or involuntary), or becomes insolvent, or goes
out of business;”

 

7.43
Section 13.1 (Definitions). The definition of Eligible Accounts set forth in Section 13.1 is hereby amended by (i)
deleting “; and” at the end of subsection (v) and replacing it with “;”, (ii) deleting “.”
at the end of subsection (w) and replacing it with “;”, and (iii) inserting the following appearing as subsections
(x), (y), (z), (aa), and (bb) thereto:

 

“(x)
Accounts in which Bank does not have a first priority, perfected security interest under all applicable laws;

 

(y)
Accounts billed and/or payable in a Currency other than Dollars;

 

(z)
Accounts with or in respect of accruals for marketing allowances, incentive rebates, price protection, cooperative advertising
and other similar marketing credits, unless otherwise approved by Bank in writing;

 

(aa)
Accounts owing from an Account Debtor which is a government entity or any department, agency, or instrumentality thereof; and

 

    	 	17	 

    	 

    

 

(bb)
Accounts with customer deposits and/or with respect to which Borrower has received an upfront payment, to the extent of such customer
deposit and/or upfront payment.”

 

7.44
Section 13 (Definitions). Subsection (c) of the definition of Permitted Liens is amended in its entirety and replace with
the following:

 

“
(c) purchase money Liens or capital leases (i) on Equipment acquired or held by Borrower incurred for financing the acquisition
of the Equipment securing no more that (A) One Million Dollars ($1,000,000.00) in the aggregate amount outstanding with respect
to Parent and Delaware Subsidiary and (B) Fifteen Thousand Australian Dollars (AUD$15,000.00) with respect to Australian Borrower,
or (ii) existing on Equipment when acquired, if the Lien is confined to the property and improvements and the proceeds of the
Equipment;”

 

7.45
Section 13 (Definitions). The following terms and their respective definitions set forth in Section 13.1 are amended in their
entirety and replaced with the following:

 

“
“Account” is, as to any Person, any “account” of such Person as “account” is defined
in the Code with such additions to such term as may hereafter be made, and includes, without limitation, all accounts receivable
and other sums owing to such Person.”

 

“
“Affiliate” is, with respect to any Person, each other Person that owns or controls directly or indirectly
the Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s
senior executive officers, directors, partners and, for any Person that is a limited liability company, that Person’s managers
and members. For purposes of the definition of Eligible Accounts, Affiliate shall include a Specified Affiliate.”

 

“
“Availability Amount” is (a) the lesser of (i) the Revolving Line or (ii) the amount available under the Borrowing
Base minus, commencing upon the occurrence of the Second Equity Event, (b) the aggregate Dollar Equivalent amount of all outstanding
Letters of Credit (including drawn but unreimbursed Letters of Credit plus an amount equal to the Letter of Credit Reserve, and
minus (c) the outstanding principal balance of any Advances.”

 

“
“Bank Services” are any products, credit services, and/or financial accommodations previously, now, or hereafter
provided to Borrower or any of its Subsidiaries by Bank or any Bank Affiliate, including, without limitation, any letters of credit,
cash management services (including, without limitation, merchant services, direct deposit of payroll, business credit cards,
and check cashing services), interest rate swap arrangements, and foreign exchange services as any such products or services may
be identified in Bank’s various agreements related thereto (each, a “Bank Services Agreement”) and shall
include, without limitation, any Letters of Credit pursuant to Section 2.8.”

 

    	 	18	 

    	 

    

 

“
“Change in Control” means (a) at any time, any “person” or “group” (as such terms are
used in Sections 13(d) and 14(d) of the Exchange Act), shall become, or obtain rights (whether by means of warrants, options or
otherwise) to become, the “beneficial owner” (as defined in Rules 13(d)-3 and 13(d)-5 under the Exchange Act), directly
or indirectly, of forty-nine percent (49.0%) or more of the ordinary voting power for the election of directors of Borrower (determined
on a fully diluted basis) other than by the sale of Borrower’s equity securities in a public offering or to venture capital
or private equity investors so long as Borrower identifies to Bank the venture capital or private equity investors at least seven
(7) Business Days prior to the closing of the transaction and provides to Bank a description of the material terms of the transaction;
(b) during any period of twelve (12) consecutive months, a majority of the members of the board of directors or other equivalent
governing body of Borrower cease to be composed of individuals (i) who were members of that board or equivalent governing body
on the first day of such period, (ii) whose election or nomination to that board or equivalent governing body was approved by
individuals referred to in clause (i) above constituting at the time of such election or nomination at least a majority of that
board or equivalent governing body or (iii) whose election or nomination to that board or other equivalent governing body was
approved by individuals referred to in clauses (i) and (ii) above constituting at the time of such election or nomination at least
a majority of that board or equivalent governing body; (c) at any time, Borrower shall cease to own and control, of record and
beneficially, directly or indirectly, one hundred percent (100.0%) of each class of outstanding capital stock of each Subsidiary
of Borrower free and clear of all Liens (except Liens created by this Agreement and the Australian Security and Guarantee); or
(d) without limiting the foregoing, in respect of the Australian Borrower, there is a change of Control where ‘Control’:
(i) has the meaning given in section 50AA of the Corporations Act; (ii) in respect of an ‘entity’ (as defined in the
Corporations Act) includes the direct or indirect power to directly or indirectly direct the management or policies of the entity
or control the membership or voting of the board of directors or other governing body of the entity; and (iii) includes owning
or controlling, directly or indirectly, more than fifty percent (50.0%) of the shares or units in an entity.”

 

“
“Code” is (a) with respect to Parent, Delaware Subsidiary, and Vivo or any assets located in the United States,
the Uniform Commercial Code, as the same may, from time to time, be enacted and in effect in the State of New York; provided,
that, to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently
in different Articles or Divisions of the Code, the definition of such term contained in Article or Division 9 shall govern; provided
further, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority
of, or remedies with respect to, Bank’s Lien on any Collateral is governed by the Uniform Commercial Code in effect in a
jurisdiction other than the State of New York, the term “Code” shall mean the Uniform Commercial Code as enacted and
in effect in such other jurisdiction solely for purposes of the provisions thereof relating to such attachment, perfection, priority,
or remedies and for purposes of definitions relating to such provisions, and (b) with respect to Australian Borrower and to any
assets located in Australia, the PPS Law.”

 

    	 	19	 

    	 

    

 

“
“Collateral” is (a) with respect to Parent, Delaware Subsidiary, and Vivo, any and all properties, rights and
assets of Borrower described on Exhibit A and (b) with respect to Australian Borrower, any and all properties, rights and assets
of Borrower granted by Australian Borrower to Bank or arising under Australian law or other applicable law, now, or in the future,
including, without limitation, the “Secured Property” as defined in the Australian Security and Guarantee.”

 

“
“Collateral Account” is any Deposit Account, Securities Account, Commodity Account, or ADI Account.”

 

“
“Credit Extension” is any Advance, any Overadvance, any Letter of Credit, or any other extension of credit
by Bank for Borrower’s benefit.”

 

“
“Designated Deposit Account” is account number ending in 945 (last three digits), maintained by Borrower with
Bank (provided, however, if no such account number is included, then the Designated Deposit Account shall be any deposit account
of Borrower maintained with Bank as chosen by Bank).”

 

“
“Dollars,” “dollars” or use of the sign “$” means only lawful money of
the United States and not any other currency, regardless of whether that currency uses the “$” sign to denote its
currency or may be readily converted into lawful money of the United States, except where the terms “Australian Dollars”
or “AUD$” are used to denote lawful money of Australia.”

 

“
“Eligible Foreign Accounts” means Accounts which are billed from and/or payable to Borrower in the United
States, but are owing from an Account Debtor which does not have its principal place of business in the United States or
Canada or whose billing address (as set forth in the applicable invoice for such Account) is not in the United States or
Canada, but are otherwise Eligible Accounts. For the avoidance of doubt, Eligible Foreign Accounts shall include Novartis AG,
Reckitt Benckiser Group Plc., and Alkermes Plc.”

 

“
“GAAP” (a) in respect of Australian Borrower, means accounting standards, principles and practices applying
by law or otherwise generally accepted and consistently applied in Australia; and (b) in respect of Parent, Delaware Subsidiary
and Vivo, is generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles
Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting
Standards Board or in such other statements by such other Person as may be approved by a significant segment of the accounting
profession, which are applicable to the circumstances as of the date of determination.”

 

    	 	20	 

    	 

    

 

“
“Guarantor” is any present or future guarantor of the Obligations, including, without limitation, Australian
Parent.”

 

“
“IP Agreement” is, collectively, (i) that certain Intellectual Property Security Agreement dated as of the
Effective Date by and between Parent and Bank, (ii) that certain Intellectual Property Security Agreement dated as of the Effective
Date by and between Delaware Subsidiary and Bank, (iii) that certain Intellectual Property Security Agreement dated as of the
2018 Amendment Date by and between Vivo and Bank, and (iv) that certain Intellectual Property Security Agreement dated as of the
2018 Amendment Date by and between Australian Borrower and Bank, as each may be amended, modified or restated from time to time.”

 

“
“Letter of Credit” means a standby letter of credit issued by Bank or another institution based upon an application,
guarantee, indemnity or similar agreement on the part of Bank as set forth in Section 2.8.”

 

“
“Loan Documents” are, collectively, this Agreement and any schedules, exhibits, certificates, notices, and
any other documents related to this Agreement, the Perfection Certificate, the Subordination Agreement, the IP Agreement, the
Australian Security and Guarantee, any Bank Services Agreement, any subordination agreement, any note, or notes or guaranties
executed by Borrower or any Guarantor, and any other present or future agreement by Borrower and/or any Guarantor with or for
the benefit of Bank in connection with this Agreement or Bank Services, all as amended, restated, or otherwise modified.”

 

“
“Operating Documents” are, for any Person (other than the Australian Borrower), such Person’s formation
documents, as certified by the Secretary of State (or equivalent agency) of such Person’s jurisdiction of organization on
a date that is no earlier than thirty (30) days prior to the Effective Date, and, (a) if such Person is a corporation, its bylaws
in current form, (b) if such Person is a limited liability company, its limited liability company agreement (or similar agreement),
and (c) if such Person is a partnership, its partnership agreement (or similar agreement), each of the foregoing with all current
amendments or modifications thereto, and in relation to the Australian Borrower, means its constitution.”

 

“
“Responsible Officer” is, with respect to Parent, Delaware Subsidiary, and Vivo, any of the Chief Executive
Officer, Chief Operating Officer and Chief Administrative Officer of Borrower or in respect of Australian Borrower, the Australian
equivalent of such officers.”

 

    	 	21	 

    	 

    

 

“
“Subsidiary” is, as to any Person, a corporation, partnership, limited liability company or other entity of
which shares of stock or other ownership interests having ordinary voting power (other than stock or such other ownership interests
having such power only by reason of the happening of a contingency) to elect a majority of the board of directors or other managers
of such corporation, partnership or other entity are at the time owned, or the management of which is otherwise controlled, directly
or indirectly through one or more intermediaries, or both, by such Person, and in relation to the Australian Borrower, without
limiting the foregoing, includes a subsidiary as defined in the Corporations Act including any entity controlled by the Australian
Borrower for the purposes of section 50AA of the Corporations Act. Unless the context otherwise requires, each reference to a
Subsidiary herein shall be a reference to a Subsidiary of Borrower or Guarantor.”

 

7.46
Section 13 (Definitions). The Loan Agreement shall be amended by inserting the following new definitions to appear alphabetically
in Section 13.1 thereof:

 

“
“2018 Amendment Date” is June 21, 2018.”

 

“
“ADI Account” is any “ADI account” as defined in the PPSA with such additions to such term as may
hereafter be made.”

 

“
“Administrator” is an individual that is named:

 

(a)
as an “Administrator” in the “SVB Online Services” form completed by Borrower with the authority to determine
who will be authorized to use SVB Online Services (as defined in Bank’s Online Banking Agreement as in effect from time
to time) on behalf of Borrower; and

 

(b)
as an Authorized Signer of Borrower in an approval by the Board.”

 

“
“Australian Borrower” is RDDT A vivoPharm Company Pty Ltd ACN 123 380 110, a company incorporated under the
laws of Australia and a Borrower hereunder.”

 

“
“Australian Insolvency Proceeding” means in respect of Australian Borrower: (a) except with Bank’s consent:
(i) it is the subject of a Liquidation, or an order or an application is made for its Liquidation; or (ii) an effective resolution
is passed or meeting summoned or convened to consider a resolution for its Liquidation; (b) an External Administrator is appointed
to it or any of its assets or a step is taken to do so or any related body requests such an appointment; (c) a step is taken under
section 601AA, 601AB or 601AC of the Corporations Act to cancel its registration; or (d) an analogous or equivalent event to any
listed above occurs in any jurisdiction.”

 

“
“Australian Parent” is vivoPharm Pty Ltd ACN 106 101 615, a company incorporated under the laws of Australia
and a Guarantor hereunder.”

 

    	 	22	 

    	 

    

 

“
“Australian Security and Guarantee” means the document titled “General Security Deed and Guarantee and
Indemnity” executed by Australian Borrower and Australian Parent in favor of Bank dated as of the 2018 Amendment Date, as
may be amended, modified, restated, replaced or supplemented from time to time.”

 

“
“Borrowing Base Report” is that certain report of the value of certain Collateral in the form specified by
Bank to Borrower from time to time.”

 

“
“Corporations Act” means the Corporations Act 2001 (Cth).”

 

“
“External Administrator” means in respect of Australian Borrower, an administrator, controller or managing
controller (each as defined in the Corporations Act), trustee, provisional liquidator, liquidator or any other person (however
described) holding or appointed to an analogous office or acting or purporting to act in an analogous capacity.”

 

“
“Letter of Credit Application” is defined in Section 2.8(b).”

 

“
“Letter of Credit Reserve” is defined in Section 2.8(e).”

 

“
“Liquidation” means, in respect of Australian Borrower: (a) a winding up, dissolution, liquidation, provisional
liquidation, administration, bankruptcy or other proceeding for which an External Administrator is appointed, or an analogous
or equivalent event or proceeding in any jurisdiction; or (b) an arrangement, moratorium, assignment or composition with or for
the benefit of creditors or any class or group of them.”

 

“
“PNC Account” is defined in Section 6.8(a).”

 

“
“PNC Transition Period” is the period of time commencing on the 2018 Amendment Date and continuing through
the earlier to occur of (a) October 19, 2018 or (b) an Event of Default.”

 

“
“PPS Law” means:

 

(a)
the PPSA and any regulation made at any time under the PPSA, including the PPS Regulations (each as amended from time to time);
and

 

(b)
any amendment made at any time to any other legislation as a consequence of a law or regulation referred to in paragraph (a) of
this definition.”

 

“
“PPS Regulations” means the Personal Property Securities Regulations 2010 (Commonwealth of Australia).”

 

    	 	23	 

    	 

    

 

“
“PPSA” means the Personal Properties Securities Act 2009 (Commonwealth of Australia).”

 

“
“Specified Affiliate” is any Person (a) more than ten percent (10.0%) of whose aggregate issued and outstanding
equity or ownership securities or interests, voting, non-voting or both, are owned or held directly or indirectly, beneficially
or of record, by Borrower, and/or (b) whose equity or ownership securities or interests representing more than ten percent (10.0%)
of such Person’s total outstanding combined voting power are owned or held directly or indirectly, beneficially or of record,
by Borrower.”

 

“
“Taxes” means any present or future taxes, levies, duties, imposts or other charges or withholdings of a similar
nature (including any penalty or interest payable in connection with any failure to pay or any delay in paying any of the same)
and, in addition to the foregoing, with respect to Australian Borrower, includes stamp duty and GST (as defined in the A New Tax
System (Goods and Services Tax) Act 1999 (Cth)), and “Tax” and “Taxation” have a corresponding
meaning.”

 

“
“US Insolvency Proceeding” is any proceeding by or against any Person under the United States Bankruptcy Code,
or any other bankruptcy or insolvency law, including assignments for the benefit of creditors, compositions, extensions generally
with its creditors, or proceedings seeking reorganization, arrangement, or other relief.”

 

“
“Vivo” means vivoPharm, LLC, a Delaware limited liability company and a Borrower hereunder.”

 

“
“Westpac Accounts” is defined in Section 6.8(a).”

 

7.47
Section 13 (Definitions). The Loan Agreement shall be amended by deleting the following definition appearing in Section 13.1
thereof in its entirety:

 

“
“Guaranty” is any guarantee of all or any part of the Obligations, as the same may from time to time be amended,
restated, modified or otherwise supplemented.”

 

7.48
Exhibit A (Collateral Description). Exhibit A to the Loan Agreement is amended in its entirety and replaced with the
form attached hereto as Schedule 1.

 

7.49
Exhibit C (Compliance Certificate). The Compliance Certificate is amended in its entirety and replaced with the Compliance
Certificate in the form attached hereto as Schedule 2.

 

    	 	24	 

    	 

    

 

8.
Limitation of Amendments.

 

8.1
The amendments set forth in Section 7 above are effective for the purposes set forth herein and shall be limited precisely
as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition
of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may now have or may have in the future under or
in connection with any Loan Document.

 

8.2
This Amendment shall be construed in connection with and as part of the Loan Documents and all terms, conditions, representations,
warranties, covenants and agreements set forth in the Loan Documents, except as herein amended, are hereby ratified and confirmed
and shall remain in full force and effect.

 

9.
Representations and Warranties.
To induce Bank to enter into this Amendment, Borrower hereby represents and warrants to Bank as follows:

 

9.1
Immediately after giving effect to this Amendment (a) the representations and warranties contained in the Loan Documents are
true, accurate and complete in all material respects as of the date hereof (except to the extent such representations and warranties
relate to an earlier date, in which case they are true and correct as of such date), and (b) no Event of Default has occurred
and is continuing;

 

9.2
Borrower has the power and authority to execute and deliver this Amendment and to perform its obligations under the Loan Agreement,
as amended by this Amendment;

 

9.3
The organizational documents of Existing Borrower delivered to Bank on the Effective Date remain true, accurate and complete
and have not been amended, supplemented or restated and are and continue to be in full force and effect;

 

9.4
The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan
Agreement, as amended by this Amendment, have been duly authorized;

 

9.5
The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan
Agreement, as amended by this Amendment, do not and will not contravene (a) any law or regulation binding on or affecting Borrower,
(b) any contractual restriction with a Person binding on Borrower, (c) any order, judgment or decree of any court or other governmental
or public body or authority, or subdivision thereof, binding on Borrower, or (d) the organizational documents of Borrower;

 

9.6
The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan
Agreement, as amended by this Amendment, do not require any order, consent, approval, license, authorization or validation of,
or filing, recording or registration with, or exemption by any governmental or public body or authority, or subdivision thereof,
binding on Borrower, except as already has been obtained or made; and

 

9.7
This Amendment has been duly executed and delivered by Borrower and is the binding obligation of Borrower, enforceable against
Borrower in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization,
liquidation, moratorium or other similar laws of general application and equitable principles relating to or affecting creditors’
rights.

 

    	 	25	 

    	 

    

 

10.
Ratification of Intellectual Property
Security Agreements. Parent hereby ratifies, confirms and reaffirms,
all and singular, the terms and conditions of a certain Intellectual Property Security Agreement dated as of March 22, 2017 between
Parent and Bank, as amended by that certain First Amendment to Intellectual Property Security Agreement dated as of June 16, 2017
(as amended, the “Parent IP Security Agreement”), and acknowledges, confirms and agrees that the Parent IP
Security Agreement (a) contains an accurate and complete listing of all Intellectual Property Collateral, as defined in the Parent
IP Security Agreement, and (b) shall remain in full force and effect. Delaware Subsidiary hereby ratifies, confirms and reaffirms,
all and singular, the terms and conditions of a certain Intellectual Property Security Agreement dated as of June 16, 2017 between
Delaware Subsidiary and Bank (the “Delaware Subsidiary IP Security Agreement” and collectively with the Parent
IP Security Agreement, the “Existing Borrower IP Security Agreements), and acknowledges, confirms and agrees that
the Delaware Subsidiary IP Security Agreement (a) contains an accurate and complete listing of all Intellectual Property Collateral,
as defined in the Delaware Subsidiary IP Security Agreement, and (b) shall remain in full force and effect. Borrower hereby acknowledges
and agrees that all references in the Loan Agreement to “IP Agreement” shall mean and include, collectively, the Existing
Borrower IP Security Agreements and the New Borrower IP Security Agreement.

 

11.
Ratification of Perfection Certificates.
Parent hereby ratifies, confirms and reaffirms, all and singular, the terms and disclosures contained in the Perfection Certificate
dated as of March 22, 2017, as amended as set forth on Schedule 3 attached hereto, delivered by Parent to Bank (the “Parent
Perfection Certificate”), and acknowledges, confirms and agrees the disclosures and information Parent provided to Bank
in said Parent Perfection Certificate have not changed, as of the date hereof. Delaware Subsidiary hereby ratifies, confirms and
reaffirms, all and singular, the terms and disclosures contained in the Perfection Certificate dated as of March 22, 2017, as
amended as set forth on Schedule 4 attached hereto, delivered by Delaware Subsidiary to Bank (the “Delaware Subsidiary
Perfection Certificate” and collectively with the Parent Perfection Certificate, the “Existing Borrower Perfection
Certificates”), and acknowledges, confirms and agrees the disclosures and information Delaware Subsidiary provided to
Bank in said Delaware Subsidiary Perfection Certificate have not changed, as of the date hereof. Borrower hereby acknowledges
and agrees that all references in the Loan Agreement to “Perfection Certificate” shall mean and include, collectively,
the Existing Borrower Perfection Certificates and the New Borrower Perfection Certificate.

 

12.
Integration.
This Amendment and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations
or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the
subject matter of this Amendment and the Loan Documents merge into this Amendment and the Loan Documents.

 

13.
Counterparts.
This Amendment may be executed in any number of counterparts and all of such counterparts taken together shall be deemed to constitute
one and the same instrument.

 

14.
Effectiveness.
This Amendment shall be deemed effective upon (a) the due execution and delivery to Bank of this Amendment by each party hereto,
and (b) Borrower’s payment to Bank of Bank’s legal fees and expenses incurred in connection with this Amendment.

 

[Signature
page follows.]

 

    	 	27	 

    	 

    

 

In
Witness Whereof, this Amendment and all documents
executed in connection therewith, or relating thereto, have been negotiated, prepared and deemed to be executed by Borrower in
the United States of America. In addition, the parties hereto have caused this Amendment to be duly executed and delivered as
of the date first written above.

 

	BANK	 
	 	 
	SILICON
    VALLEY BANK	 
	 	 	 
	By:
    	/s/
    Nathan Meaux	 
	Name:
    	Nathan
    Meaux	 
	Title:	Vice
    President	 

 

	BORROWER	 
	 	 	 
	CANCER
    GENETICS, INC.	 
	 	 	 
	By:	/s/
    John A. Roberts	 
	Name:	John
    A. Roberts 	 
	Title:	Chief
    Executive Officer	 
	 	 	 
	GENTRIS,
    LLC	 
	 	 	 
	By:	/s/
    John A. Roberts 	 
	Name:	John
    A. Roberts	 
	Title:
    	Chief
    Executive Officer 	 
	 	 	 
	VIVOPHARM,
    LLC	 
	 	 	 
	By:	/s/
    John A. Roberts 	 
	Name:	John
    A. Roberts 	 
	Title:
    	Chief
    Executive Officer	 

 

[Signature
page to Joinder and Second Amendment to

Amended
and Restated Loan and Security Agreement]

 

    	 

    	 

    

 

	Executed
                                         by RDDT A VIVOPHARM

                                                                     COMPANY
                                         PTY LTD in accordance with

                                                                     Section
                                         127 of the Corporations Act 2001
	 	 
	 	 	 
	/s/
    John A. Roberts	 	/s/
    Ralf Brandt
	Signature
    of director	 	Signature
                                         of director/company secretary

        (Please
        delete as applicable)

	John
    A. Roberts	 	Ralf
    Brandt
	Name
    of director (print)	 	Name
    of director/company secretary (print)

 

The
undersigned hereby certifies, to the best of his or her knowledge, that the information set out in the Parent Perfection Certificate
is true, complete and correct.

 

	 	Date:
    June 21, 2018 
	 	 	 
	 	CANCER
    GENETICS, INC.
	 	 	 
	 	By:	/s/
    John A. Roberts
	 	Name:	John
    A. Roberts
	 	Title:	Chief
    Executive Officer 
	 	Email:	jay.roberts@cgix.com
    
	 	Phone:	   201-528-9200 

 

The
undersigned hereby certifies, to the best of his or her knowledge, that the information set out in the Delaware Subsidiary Perfection
Certificate is true, complete and correct.

 

	 	Date:
    June 21, 2018 
	 	 	 
	 	GENTRIS,
    LLC
	 	 	 
	 	By:	/s/
    John A. Roberts
	 	Name:	John
    A. Roberts
	 	Title:	Chief
    Executive Officer 
	 	Email:	jay.roberts@cgix.com
    
	 	Phone:	   201-528-9200

 

[Signature
page to Joinder and Second Amendment to

Amended
and Restated Loan and Security Agreement]

 

    	 

    	 

    

 

Schedule
1

 

The
Collateral consists of all of Parent’s, Delaware Subsidiary’s and Vivo’s right, title and interest in and to
the following personal property:

 

All
goods, Accounts (including health-care receivables), Equipment, Inventory, contract rights or rights to payment of money, leases,
license agreements, franchise agreements, General Intangibles, Intellectual Property, domain names, commercial tort claims, documents,
instruments (including any promissory notes), chattel paper (whether tangible or electronic), cash, deposit accounts, certificates
of deposit, fixtures, letters of credit rights (whether or not the letter of credit is evidenced by a writing), securities, and
all other investment property, supporting obligations, and financial assets, whether now owned or hereafter acquired, wherever
located; and

 

all
Borrower’s Books relating to the foregoing, and any and all claims, rights and interests in any of the above and all substitutions
for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds
of any or all of the foregoing.

 

Notwithstanding
the foregoing, the Collateral does not include any of the following: (a) more than sixty-five percent (65%) of the presently existing
and hereafter arising issued and outstanding shares of capital stock owned by Borrower of any Foreign Subsidiary which shares
entitle the holder thereof to vote for directors or any other matter, (b) any security deposits provided to landlords in the ordinary
course of business, (c) the CD Accounts, or (c) motor vehicles.

 

    	 

    	 

    

 

Schedule
2

 

EXHIBIT
B

 

COMPLIANCE
CERTIFICATE

  

	TO:
                           SILICON VALLEY BANK

	Date: ______________________

 

FROM:
Cancer Genetics, Inc., Gentris, LLC, VIVOPHARM, LLC, and RDDT
A VIVOPHARM COMPANY PTY LTD

 

The
undersigned authorized officer of Cancer Genetics, Inc., Gentris, LLC, and RDDT
A VIVOPHARM COMPANY PTY LTD (collectively, “Borrower”) certifies that under the terms and conditions
of the Amended and Restated Loan and Security Agreement between Borrower and Bank (the “Agreement”), (1) Borrower
is in complete compliance for the period ending _______________ with all required covenants except as noted below, (2) there are
no Events of Default, (3) all representations and warranties in the Agreement are true and correct in all material respects on
this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any
representations and warranties that already are qualified or modified by materiality in the text thereof; and provided,
further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete
in all material respects as of such date, (4) Borrower, and each of its Subsidiaries, has timely filed all required tax returns
and reports, and Borrower has timely paid all foreign, federal, state and local taxes, assessments, deposits and contributions
owed by Borrower except as otherwise permitted pursuant to the terms of Section 5.9 of the Agreement, and (5) no Liens have been
levied or claims made against Borrower or any of its Subsidiaries, if any, relating to unpaid employee payroll or benefits of
which Borrower has not previously provided written notification to Bank.

 

Attached
are the required documents supporting the certification. The undersigned certifies that these are prepared in accordance with
GAAP consistently applied from one period to the next except as explained in an accompanying letter or footnotes. The undersigned
acknowledges that no borrowings may be requested at any time or date of determination that Borrower is not in compliance with
any of the terms of the Agreement, and that compliance is determined not just at the date this certificate is delivered. Capitalized
terms used but not otherwise defined herein shall have the meanings given them in the Agreement.

 

	Please
    indicate compliance status by circling Yes/No under “Complies” column.
	 
	Reporting
    Covenants	 	Required	 	Complies
	 	 	 	 	 
	Monthly
                                         financial statements (consolidated and

        consolidating)
        with Compliance Certificate
	 	Monthly
    within 30 days	 	Yes
    No
	Annual
    financial statements (CPA Audited)	 	Earlier
    of FYE within 150 days or within 5 days after filing with SEC	 	Yes
    No
	10-Q,
    10-K and 8-K	 	Within
    5 days after filing with SEC	 	Yes
    No
	A/R
    & A/P Agings and Deferred Revenue reports	 	Monthly
    within 30 days	 	Yes
    No
	Board-approved
    Projections	 	FYE
    within 60 days	 	Yes
    No
	Borrowing
    Base Reports	 	Monthly
    within 7 days and with each Advance request	 	Yes
    No
	13-week
    cash flow forecast (prior to the occurrence of the Second Equity Event)	 	Weekly
    on Friday of each week	 	Yes
    No

 

The
following Intellectual Property was registered after the Effective Date (if no registrations, state “None”) ____________________________________________________________________________
 

 

    	 

    	 

    

 

	Financial
    Covenants	 	Required	 	Actual	 	Complies
	 	 	 	 	 	 	 
	Maintain
    as indicated:	 	 	 	 	 	 
	Adjusted
    EBITDA (three-month, tested monthly)	 	*$________	 	$________	 	Yes
    No
	Minimum
    Revenue (tested quarterly)	 	**$________	 	$________	 	Yes
    No
	Minimum
    Liquidity (tested monthly)	 	$2,000,000.00	 	$________	 	Yes
    No

 

*As
set forth in Section 6.9(a)

*As
set forth in Section 6.9(b)

 

	Streamline
    Period	 	Required	 	Actual	 	Complies
	Maintain:	 	 	 	 	 	 
	Adjusted
    Quick Ratio 	 	>
    1.50:1.0	 	_____:1.0	 	Yes
    No

 

The
following financial covenant analyses and information set forth in Schedule 1 attached hereto are true and accurate as
of the date of this Certificate.

 

Other
Matters

 

	Have
    there been any amendments of or other changes to the capitalization table of Borrower and to the Operating Documents of Borrower
    or any of its Subsidiaries? If yes, provide copies of any such amendments or changes with this Compliance Certificate.	Yes	No

 

The
following are the exceptions with respect to the certification above: (If no exceptions exist, state “No exceptions to note.”)

—————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————

 

	CANCER
    GENETICS, INC.	 	BANK
    USE ONLY
		 	 	 	 
	By:
    		 	Received
    by: 	 
	Name:	 	 	 	AUTHORIZED
    SIGNER 
	Title:
    	 	 	Date:
    	 
	 	 	 		 
	GENTRIS,
    LLC	 	Verified:	 
	 	 	 	authorized
    signer
	By:
    		 	Date:	 
	Name:	 	 	 	
	Title:
    	 	 	Compliance
    Status: Yes      No
	 	 	 		 
	VIVOPHARM,
    LLC	 	 	 
	 	 	 	 
	By:
    		 	
	Name:
    		 	 	 
	Title:
    		 	 	 
	 	 	 	 	 
	RDDT
    A VIVOPHARM COMPANY PTY LTD	 	 	 
	 	 	 	 	 
	By:
    	 	 	 	 
	Name:
    		 	 	 
	Title:
    	               	 	 	 

 

    	 

    	 

    

 

Schedule
1 to Compliance Certificate

 

Financial
Covenants of Borrower

 

In
the event of a conflict between this Schedule and the Agreement, the terms of the Agreement shall govern.

 

Dated:
____________________

 

I.
Adjusted EBITDA (Section 6.9(a)) (three-months, tested monthly) (calculated on a consolidated basis with respect to Borrower
and its Subsidiaries)

 

Required:
*$___________

 

*As
set forth in Section 6.9(a)

 

Actual:
$___________

 

	A.	 	Net
    Income	 	$______

        

	 	 	 	 	 
	B.	 	To
                                         the extent included in the determination of Net Income:

        
	 	 
	 	 	 	 	 
	 	 	1.
    Interest Expenses	 	$______
	 	 	 	 	 
	 	 	2.
    depreciation expense	 	$______

        

	 	 	 	 	 
	 	 	3.
    amortization expense	 	$______

        

	 	 	 	 	 
	 	 	4.
                                         non-cash stock compensation expense

        
	 	$______

        

	 	 	 	 	 
	 	 	5.
                                         income tax expense

        
	 	$______

        

	 	 	 	 	 
	 	 	6.
                                         restructuring and severance costs (not to exceed $200,000.00 in the aggregate in any
                                         fiscal year of Borrower)

        
	 	$______

        

	 	 	 	 	 
	 	 	7.
                                         without duplication of 6, severance costs not exceeding One Hundred Ninety Thousand Dollars
                                         ($190,000.00) in the aggregate during the first (1st) quarter of Borrower’s
                                         2017 fiscal year

        
	 	$______

	 	 	 	 	 
	C.	 	The
    sum of lines 1 through 7	 	$_______

        

	 	 	 	 	 
	D.	 	Unfinanced
    capital expenditures	 	$_______

        

	 	 	 	 	 
	E.	 	Adjusted
                                         EBITDA (line A plus line C minus line D)
	 	$_______

        

 

Is
line E equal to or greater than *$________?

 

________
No, not in compliance

 

________
 Yes, in compliance

 

    	 

    	 

    

 

II.
Minimum Revenue (Section 6.9(b)) (tested quarterly for a quarterly period) (calculated on a consolidated basis with respect
to Borrower and its Subsidiaries)

 

Required:
*$___________

 

*As
set forth in Section 6.9(b)

 

Actual:
$___________

 

Is
the actual revenue equal to or greater than *$________?

 

________
 No, not in compliance

 

________
Yes, in compliance

 

III.
Minimum Liquidity (Section 6.9(c)) (tested monthly) (calculated with respect to Borrower only, and not on a consolidated
basis)

 

Required:
$2,000,000.00

 

Actual:
$___________

 

	A.	 	Aggregate
    amount of unrestricted and unencumbered cash held at such time by Borrower in accounts maintained with Bank	 	$______

        

	 	 	 	 	 
	B.	 	Availability
    Amount	 	$_______

        

	 	 	 	 	 
	C.	 	Liquidity
                                         (line A plus line B)

        
	 	$_______

        

 

Is
line C equal to or greater than $2,000,000.00?

 

________
 No, not in compliance

 

________
Yes, in compliance

 

    	 

    	 

    

 

Schedule
3

 

Amendments
to Parent Perfection Certificate 

 

	 	1.	Section 2 of the
    Parent Perfection Certificate is amended by inserting the following text to appear as new subsections (d) and (e) thereof,
    immediately following subsection (c) thereof:

 

“
d. Does any individual, directly or indirectly (for example, if applicable, through such individual’s
equity interests in the Company’s parent entity), through any contract, arrangement, understanding, relationship or otherwise,
own 25% or more of the equity interests of the Company:

 

Yes
[  ] No [X]

 

If
yes, complete the following information:

 

	 	 	Name	 	Date
                                         of

                                                                                birth
	 	Residential

                                                                                address
	 	For
                                         US

                                                                     Persons,

                                                                     Social

                                                                     Security

                                                                     Number:

        (non-US

        persons

        should

        provide
        SSN

        if
        available)
	 	For
                                         Non-US P

                                                                                ersons:
                                         Type

                                                                                of
                                         ID, ID

                                                                                number,

                                                                                country
                                         of

                                                                                issuance,

                                                                                expiration
                                         date
	 	Percentage

                                                                     of

                                                                     ownership

        (if
        indirect

        ownership,

        explain

        structure)

	1	 	 	 	 	 	 	 	 	 	 	 	 
	2	 	 	 	 	 	 	 	 	 	 	 	 
	3	 	 	 	 	 	 	 	 	 	 	 	 
	4	 	 	 	 	 	 	 	 	 	 	 	 

 

e.
Identify one individual with significant responsibility for managing the Company, i.e., an executive officer or senior manager
(e.g., Chief Executive Officer, President, Vice President, Chief Financial Officer, Treasurer, Chief Operating Officer, Managing
Member or General Partner) or any other individual who regularly performs similar functions. If appropriate, an individual listed
in Section 2(d) above may also be listed here.

 

	 	 	Name	 	Date
    of birth	 	Residential
    address	 	For
                                         US Persons, Social Security Number:

        (non-US
        persons should provide SSN if available)
	 	For
                                         Non-

                                                                                US
                                         Persons:

                                                                                Type
                                         of ID,

                                                                                ID
                                         number, country of issuance, expiration date

	1	 	John
    A. Roberts	 	June
    26, 1958	 	 	 	 	 	N/A

”

 

    	 

    	 

    

 

Schedule
4

 

Amendments
to Delaware Subsidiary Perfection Certificate 

 

	 	1.	Section 2 of the Delaware Subsidiary Perfection
    Certificate is amended by inserting the following text to appear as new subsections (d) and (e) thereof, immediately following
    subsection (c) thereof:	 

 

“
d. Does any individual, directly or indirectly (for example, if applicable, through such individual’s
equity interests in the Company’s parent entity), through any contract, arrangement, understanding, relationship or otherwise,
own 25% or more of the equity interests of the Company:

 

Yes
[  ] No [X]

 

If
yes, complete the following information:

 

	 	 	Name	 	Date
                                         of

                                                                                birth
	 	Residential
    address	 	For
                                         US Persons, Social Security Number:

        (non-US
        persons should provide SSN if available)
	 	For
    Non-US Persons: Type of ID, ID number, country of issuance, expiration date	 	Percentage
                                         of ownership

        (if
        indirect ownership, explain structure)

	1	 	 	 	 	 	 	 	 	 	 	 	 
	2	 	 	 	 	 	 	 	 	 	 	 	 
	3	 	 	 	 	 	 	 	 	 	 	 	 
	4	 	 	 	 	 	 	 	 	 	 	 	 

 

e.
Identify one individual with significant responsibility for managing the Company, i.e., an executive officer or senior manager
(e.g., Chief Executive Officer, President, Vice President, Chief Financial Officer, Treasurer, Chief Operating Officer, Managing
Member or General Partner) or any other individual who regularly performs similar functions. If appropriate, an individual listed
in Section 2(d) above may also be listed here.

 

	 	 	Name	 	Date
                                         of birth
	 	Residential

                                                                                address
	 	For
                                         US Persons, Social Security Number:

        (non-US
        persons should provide SSN if available)
	 	For
                                         Non-

                                                                                US
                                         Persons:

                                                                                Type
                                         of ID,

                                                                                ID
                                         number,

                                                                                country
                                         of issuance,

                                                                                expiration

                                                                                date

	1	 	John
    A. Roberts	 	June
    26, 1958	 	 	 	 	 	N/A

”Exhibit

EXHIBIT 4.4

APPENDIX A
PARK-OHIO HOLDINGS CORP.
2018 EQUITY AND INCENTIVE COMPENSATION PLAN
1. Purpose. The purpose of this Plan is to attract and retain Directors, officers and other key employees of the Company and its Subsidiaries and to provide to such persons incentives and rewards for performance.
2. Definitions. As used in this Plan:
(a) “Affiliate” means any corporation, partnership, joint venture or other entity, directly or indirectly, through one or more intermediaries, controlling, controlled by, or under common control with the Company as determined by the Committee or the Board, as applicable, in its discretion.
(b) “Appreciation Right” means a right granted pursuant to Section 5 of this Plan, and will include both Free-Standing Appreciation Rights and Tandem Appreciation Rights.
(c) “Base Price” means the price to be used as the basis for determining the Spread upon the exercise of a Free-Standing Appreciation Right or a Tandem Appreciation Right.
(d) “Board” means the Board of Directors of the Company.
(e) “Cash Incentive Award” means a cash award granted pursuant to Section 8 of this Plan.
(f) “Change in Control” has the meaning set forth in Section 12 of this Plan.
(g) “Code” means the Internal Revenue Code of 1986, as amended from time to time.
(h) “Committee” means the Compensation Committee of the Board (or its successor(s)), or any other committee of the Board designated by the Board to administer this Plan pursuant to Section  10 of this Plan consisting solely of no fewer than two Non-Employee Directors.
(i) “Common Shares” means the shares of Common Stock, par value $1.00 per share, of the Company or any security into which such common shares may be changed by reason of any transaction or event of the type referred to in Section 11 of this Plan.
(j) “Company” means Park-Ohio Holdings Corp., an Ohio corporation, and its successors.
(k) “Date of Grant” means the date specified by the Committee on which a grant of Option Rights, Appreciation Rights, Performance Shares, Performance Units, Cash Incentive Awards, or other awards contemplated by Section 9 of this Plan, or a grant or sale of Restricted Shares, Restricted Stock Units, or other awards contemplated by Section 9 of this Plan, will become effective (which date will not be earlier than the date on which the Committee takes action with respect thereto).
(l) “Director” means a member of the Board.
(m) “Effective Date” means the date this Plan is approved by the Shareholders of the Company.
(n) “Evidence of Award” means an agreement, certificate, resolution or other type or form of writing or other evidence approved by the Committee that sets forth the terms and conditions of the awards granted under the Plan. An Evidence of Award may be in an electronic medium, may be limited to notation on the books and records of the Company and, unless otherwise determined by the Committee, need not be signed by a representative of the Company or a Participant.
 
(o) “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder, as such law, rules and regulations may be amended from time to time.

1

EXHIBIT 4.4

(p) “Free-Standing Appreciation Right” means an Appreciation Right granted pursuant to Section 5 of this Plan that is not granted in tandem with an Option Right.
(q) “Incentive Stock Options” means Option Rights that are intended to qualify as “incentive stock options” under Section 422 of the Code or any successor provision.
(r) “Management Objectives” means the measurable performance objective or objectives established pursuant to this Plan for Participants who have received grants of Performance Shares, Performance Units or Cash Incentive Awards or, when so determined by the Committee, Option Rights, Appreciation Rights, Restricted Shares, Restricted Stock Units, dividend equivalents or other awards pursuant to this Plan. If the Committee determines that a change in the business, operations, corporate structure or capital structure of the Company, or the manner in which it conducts its business, or other events or circumstances render the Management Objectives unsuitable, the Committee may in its discretion modify such Management Objectives or the acceptable levels of achievement, in whole or in part, as the Committee deems appropriate and equitable.
(s) “Market Value per Share” means, as of any particular date, the closing price of a Common Share as reported for that date on the Nasdaq Stock Market, if the Common Shares are not then listed on the Nasdaq Stock Market, on any other national securities exchange on which the Common Shares are listed, or if there are no sales on such date, on the next preceding trading day during which a sale occurred. If there is no regular public trading market for the Common Shares, then the Market Value per Share shall be the fair market value as determined in good faith by the Committee. The Committee is authorized to adopt another fair market value pricing method provided such method is stated in the Evidence of Award and is in compliance with the fair market value pricing rules set forth in Section 409A of the Code.
(t) “Non-Employee Director” means a person who is a “Non-Employee Director” of the Company within the meaning of Rule 16b-3 promulgated under the Exchange Act.
(u) “Optionee” means the optionee named in an Evidence of Award evidencing an outstanding Option Right.
(v) “Option Price” means the purchase price payable on exercise of an Option Right.
(w) “Option Right” means the right to purchase Common Shares upon exercise of an option granted pursuant to Section 4 of this Plan.
(x) “Participant” means a person who is selected by the Committee to receive benefits under this Plan and who is at the time (i) an officer or other employee of the Company or any Subsidiary, (ii) a person who provides services to the Company or a Subsidiary that are equivalent to those typically provided by an employee (provided that such person satisfies the Form S-8 definition of an “employee”), or (iii) a non-employee Director.
(y) “Performance Period” means, in respect of a Cash Incentive Award, Performance Share or Performance Unit, a period of time established pursuant to Section  8 of this Plan within which the Management Objectives relating to such Cash Incentive Award, Performance Share or Performance Unit are to be achieved.
(z) “Performance Share” means a bookkeeping entry that records the equivalent of one Common Share awarded pursuant to Section 8 of this Plan.
(aa) “Performance Unit” means a bookkeeping entry awarded pursuant to Section 8 of this Plan that records a unit equivalent to $1.00 or such other value as is determined by the Committee.
(bb) “Plan” means this Park-Ohio Holdings Corp. 2018 Equity and Incentive Compensation Plan. 
(cc) “Predecessor Plan” means the Company’s 2015 Equity and Incentive Compensation Plan.
(dd) “Restricted Shares” means Common Shares granted or sold pursuant to Section  6 of this Plan as to which neither the substantial risk of forfeiture nor the prohibition on transfers has expired.

2

EXHIBIT 4.4

(ee) “Restricted Stock Units” means an award made pursuant to Section 7 of this Plan of the right to receive Common Shares, cash or a combination thereof at the end of a specified period.
(ff) “Restriction Period” means the period of time during which Restricted Stock Units are subject to restrictions, as provided in Section 7 of this Plan.
(gg) “Shareholder” means an individual or entity that owns one or more Common Shares.
(hh) “Spread” means the excess of the Market Value per Share on the date when an Appreciation Right is exercised over the Option Price or Base Price provided for in the related Option Right or Free-Standing Appreciation Right, respectively.
(ii) “Subsidiary” means a corporation, company or other entity (i) more than 50 percent of whose outstanding shares or securities (representing the right to vote for the election of directors or other managing authority) are, or (ii) which does not have outstanding shares or securities (as may be the case in a partnership, joint venture, limited liability company, or unincorporated association), but more than 50 percent of whose ownership interest representing the right generally to make decisions for such other entity is, now or hereafter, owned or controlled, directly or indirectly, by the Company; provided , however , that for purposes of determining whether any person may be a Participant for purposes of any grant of Incentive Stock Options, “Subsidiary” means any corporation in which at the time the Company owns or controls, directly or indirectly, more than 50 percent of the total combined Voting Power represented by all classes of stock issued by such corporation.
(jj) “Tandem Appreciation Right” means an Appreciation Right granted pursuant to Section 5 of this Plan that is granted in tandem with an Option Right.
(kk) “Voting Power” means at any time, the combined voting power of the then-outstanding securities entitled to vote generally in the election of Directors in the case of the Company, or members of the board of directors or similar body in the case of another entity.
3. Shares Available Under the Plan.
(a) Maximum Shares Available Under this Plan .
 
	
			
	 
	(i)
	Subject to adjustment as provided in Section  11 of this Plan and the share counting rules set forth in Section  3(a)(ii) of this Plan, the number of Common Shares that may be issued or transferred (A) upon the exercise of Option Rights or Appreciation Rights, (B) as Restricted Shares and released from substantial risks of forfeiture thereof, (C) in payment of Restricted Stock Units, (D) in payment of Performance Shares or Performance Units that have been earned, (E) as awards contemplated by Section  9 of this Plan, or (F) in payment of dividend equivalents paid with respect to awards made under this Plan will not exceed in the aggregate 750,000 Common Shares. Such shares may be shares of original issuance or treasury shares or a combination of the foregoing.

 
	
			
	 
	(ii)
	Common Shares covered by an award granted under this Plan will not be counted as used unless and until they are actually issued and delivered to a Participant. If any Common Shares issued or transferred pursuant to an award granted under this Plan are forfeited, or an award granted under this Plan is cancelled or forfeited, expires or is settled for cash (in whole or in part), the Common Shares issued or transferred pursuant to, or subject to, such award

 
	
		
	 
	(as applicable) will, to the extent of such cancellation, forfeiture, expiration, or cash settlement, again be available for issuance or transfer under Section  3(a)(i) above. If, on or after the Effective Date, any Common Shares subject to an award granted under the Predecessor Plan are forfeited, or an award granted under the Predecessor Plan is cancelled or forfeited, expires or is settled for cash (in whole or in part), the Common Shares subject to such award will, to the extent of such cancellation, forfeiture, expiration, or cash settlement, be available for issuance or transfer under Section 3(a)(i) above.

3

EXHIBIT 4.4

 
	
			
	 
	(iii)
	Notwithstanding anything to the contrary contained herein, the following Common Shares will not be added to the aggregate number of Common Shares available for issuance or transfer under Section  3(a)(i) above: (A) Common Shares withheld by the Company, tendered or otherwise used in payment of the Option Price of an Option Right (or the option price of a stock option granted under the Predecessor Plan); (B) Common Shares withheld or otherwise used by the Company to satisfy a tax withholding obligation; (C) Common Shares subject to an Appreciation Right (or a stock appreciation right granted under the Predecessor Plan) that are not actually issued in connection with its Common Shares settlement on exercise thereof; and (D) Common Shares reacquired by the Company on the open market or otherwise using cash proceeds from the exercise of Option Rights (or stock options granted under the Predecessor Plan). If, under this Plan, a Participant has elected to give up the right to receive compensation in exchange for Common Shares based on fair market value, such Common Shares will not count against the aggregate plan limit described above.

(b) Limit on Incentive Stock Options. Notwithstanding anything in this Section 3, or elsewhere in this Plan, to the contrary and subject to adjustment as provided in Section 11 of this Plan, the aggregate number of Common Shares actually issued or transferred by the Company upon the exercise of Incentive Stock Options will not exceed 750,000 Common Shares.
(c) Non-Employee Director Compensation Limit. Notwithstanding anything in this Section 3, or elsewhere in this Plan, to the contrary, and subject to adjustment as provided in Section 11 of this Plan, no non-employee Director will be granted, in any period of one calendar year, awards under the Plan in excess of 50,000 Common Shares.
(d) Notwithstanding anything in this Plan to the contrary, up to 5% of the maximum number of Common Shares that may be issued or transferred under this Plan as provided for in Section 3(a) of this Plan, as may be adjusted under Section 11 of this Plan, may be used for awards granted under Section 4 through Section 9 of this Plan that do not comply with the applicable one-year minimum vesting requirements set forth in such sections of this Plan.
4. Option Rights. The Committee may, from time to time and upon such terms and conditions as it may determine, authorize the granting to Participants of Option Rights. Each such grant may utilize any or all of the authorizations, and will be subject to all of the requirements, contained in the following provisions:
(a) Each grant will specify the number of Common Shares to which it pertains subject to the limitations set forth in Section 3 of this Plan.
(b) Each grant will specify an Option Price per share, which (except with respect to awards under Section 22 of this Plan) may not be less than the Market Value per Share on the Date of Grant.
(c) Each grant will specify whether the Option Price will be payable (i) in cash or by check acceptable to the Company or by wire transfer of immediately available funds, (ii) by the actual or constructive transfer to the Company of Common Shares owned by the Optionee (or other consideration authorized pursuant to Section  4(d) of this Plan) having a value at the time of exercise equal to the total Option Price, (iii) subject to any conditions or limitations established by the Committee, the Company’s withholding of Common Shares otherwise issuable upon exercise of an Option Right pursuant to a “net exercise” arrangement (it being understood that, solely for purposes of determining the number of treasury shares held by the Company, the Common Shares so withheld will not be treated as issued and acquired by the Company upon such exercise), (iv) by a combination of such methods of payment, or (v) by such other methods as may be approved by the Committee.
(d) To the extent permitted by law, any grant may provide for deferred payment of the Option Price from the proceeds of sale through a bank or broker on a date satisfactory to the Company of some or all of the shares to which such exercise relates.

4

EXHIBIT 4.4

(e) Successive grants may be made to the same Participant whether or not any Option Rights previously granted to such Participant remain unexercised.
(f) Each grant will specify the period or periods of continuous service by the Optionee with the Company or any Subsidiary that is necessary before the Option Rights or installments thereof will become exercisable; provided that, except as otherwise described in this subsection, no grant of Option Rights may become exercisable sooner than after one year. A grant of Option Rights may provide for the earlier exercise of such Option Rights, including in the event of the retirement, death or disability of a Participant, or in the event of a Change in Control.
(g) Any grant of Option Rights may specify Management Objectives that must be achieved as a condition to the exercise of such rights.
(h) Option Rights granted under this Plan may be (i) options, including, without limitation, Incentive Stock Options that are intended to qualify under particular provisions of the Code, (ii) options that are not intended so to qualify, or (iii) combinations of the foregoing. Incentive Stock Options may only be granted to Participants who meet the definition of “employees” under Section 3401(c) of the Code.
(i) The exercise of an Option Right will result in the cancellation on a share-for-share basis of any Tandem Appreciation Right authorized under Section 5 of this Plan.
(j) No Option Right will be exercisable more than 10 years from the Date of Grant.
(k) Option Rights granted under this Plan may not provide for any dividends or dividend equivalents thereon.
(l) Each grant of Option Rights will be evidenced by an Evidence of Award. Each Evidence of Award will be subject to this Plan and will contain such terms and provisions, consistent with this Plan, as the Committee may approve.
5. Appreciation Rights.
(a) The Committee may, from time to time and upon such terms and conditions as it may determine, authorize the granting (i) to any Optionee, of Tandem Appreciation Rights in respect of Option Rights granted hereunder, and (ii) to any Participant, of Free-Standing Appreciation Rights. A Tandem Appreciation Right will be a right of the Optionee, exercisable by surrender of the related Option Right, to receive from the Company an amount determined by the Committee, which will be expressed as a percentage of the Spread (not exceeding 100 percent) at the time of exercise. Tandem Appreciation Rights may be granted at any time prior to the exercise or termination of the related Option Rights; provided, however, that a Tandem Appreciation Right awarded in relation to an Incentive Stock Option must be granted concurrently with such Incentive Stock Option. A Free-Standing Appreciation Right will be a right of the Participant to receive from the Company an amount determined by the Committee, which will be expressed as a percentage of the Spread (not exceeding 100 percent) at the time of exercise.
 (b) Each grant of Appreciation Rights may utilize any or all of the authorizations, and will be subject to all of the requirements, contained in the following provisions:
 
	
			
	 
	(i)
	Each grant may specify that the amount payable on exercise of an Appreciation Right will be paid by the Company in cash, Common Shares or any combination thereof.

 
	
			
	 
	(ii)
	Any grant may specify that the amount payable on exercise of an Appreciation Right may not exceed a maximum specified by the Committee at the Date of Grant.

 
	
			
	 
	(iii)
	Any grant may specify waiting periods before exercise and permissible exercise dates or periods.

 

5

EXHIBIT 4.4

	
			
	 
	(iv)
	Each grant may specify the period or periods of continuous service by the Participant with the Company or any Subsidiary that is necessary before the Appreciation Rights or installments thereof will become exercisable; provided that, except as otherwise described in this subsection, no grant of Appreciation Rights may become exercisable sooner than after one year. A grant of Appreciation Rights may provide for the earlier exercise of such Appreciation Rights, including in the event of the retirement, death or disability of a Participant, or in the event of a Change in Control.

 
	
			
	 
	(v)
	Any grant of Appreciation Rights may specify Management Objectives that must be achieved as a condition of the exercise of such Appreciation Rights.

 
	
			
	 
	(vi)
	Each grant of Appreciation Rights will be evidenced by an Evidence of Award, which Evidence of Award will describe such Appreciation Rights, identify the related Option Rights (if applicable), and contain such other terms and provisions, consistent with this Plan, as the Committee may approve.

(c) Any grant of Tandem Appreciation Rights will provide that such Tandem Appreciation Rights may be exercised only at a time when the related Option Right is also exercisable and at a time when the Spread is positive, and by surrender of the related Option Right for cancellation. Successive grants of Tandem Appreciation Rights may be made to the same Participant regardless of whether any Tandem Appreciation Rights previously granted to the Participant remain unexercised.
(d) Appreciation Rights granted under this Plan may not provide for any dividends or dividend equivalents thereon.
(e) Regarding Free-Standing Appreciation Rights only:
 
	
			
	 
	(i)
	Each grant will specify in respect of each Free-Standing Appreciation Right a Base Price, which (except with respect to awards under Section  22 of this Plan) may not be less than the Market Value per Share on the Date of Grant;

 
	
			
	 
	(ii)
	Successive grants may be made to the same Participant regardless of whether any Free-Standing Appreciation Rights previously granted to the Participant remain unexercised; and

 
	
			
	 
	(iii)
	No Free-Standing Appreciation Right granted under this Plan may be exercised more than 10 years from the Date of Grant.

6. Restricted Shares. The Committee may, from time to time and upon such terms and conditions as it may determine, authorize the grant or sale of Restricted Shares to Participants. Each such grant or sale may utilize any or all of the authorizations, and will be subject to all of the requirements, contained in the following provisions:
(a) Each such grant or sale will constitute an immediate transfer of the ownership of Common Shares to the Participant in consideration of the performance of services, entitling such Participant to voting, dividend and other ownership rights, but subject to the substantial risk of forfeiture and restrictions on transfer hereinafter referred to.
(b) Each such grant or sale may be made without additional consideration or in consideration of a payment by such Participant that is less than the Market Value per Share at the Date of Grant.
(c) Each such grant or sale will provide that the Restricted Shares covered by such grant or sale will be subject to a “substantial risk of forfeiture” within the meaning of Section 83 of the Code for a period to be determined by the Committee at the Date of Grant or until achievement of Management Objectives referred to in subparagraph (e) below. If the elimination of restrictions is based only on the passage of time rather than the achievement of Management Objectives, the period of time will be no shorter than one year.

6

EXHIBIT 4.4

(d) Each such grant or sale will provide that during or after the period for which such substantial risk of forfeiture is to continue, the transferability of the Restricted Shares will be prohibited or restricted in the manner and to the extent prescribed by the Committee at the Date of Grant (which restrictions may include, without limitation, rights of repurchase or first refusal in the Company or provisions subjecting the Restricted Shares to a continuing substantial risk of forfeiture in the hands of any transferee).
(e) Any grant of Restricted Shares may specify Management Objectives that, if achieved, will result in termination or early termination of the restrictions applicable to such Restricted Shares; provided , however , that notwithstanding subparagraph (c) above, restrictions relating to Restricted Shares that vest upon the achievement of Management Objectives may not terminate sooner than after one year.
(f) Notwithstanding anything to the contrary contained in this Plan, any grant or sale of Restricted Shares may provide for the earlier termination of restrictions on such Restricted Shares, including in the event of the retirement, death or disability of a Participant, or in the event of a Change in Control.
(g) Any such grant or sale of Restricted Shares may require that any or all dividends or other distributions paid thereon during the period of such restrictions be automatically deferred and reinvested in additional Restricted Shares, which may be subject to the same restrictions as the underlying award; provided , however , that dividends or other distributions on Restricted Shares with restrictions that lapse as a result of the achievement of Management Objectives will be deferred until and paid contingent upon the achievement of the applicable Management Objectives.
(h) Each grant or sale of Restricted Shares will be evidenced by an Evidence of Award and will contain such terms and provisions, consistent with this Plan, as the Committee may approve. Unless otherwise directed by the Committee, (i) all certificates representing Restricted Shares will be held in custody by the Company until all restrictions thereon will have lapsed, together with a stock power or powers executed by the Participant in whose name such certificates are registered, endorsed in blank and covering such shares or (ii) all Restricted Shares will be held at the Company’s transfer agent in book entry form with appropriate restrictions relating to the transfer of such Restricted Shares.
7. Restricted Stock Units. The Committee may, from time to time and upon such terms and conditions as it may determine, authorize the granting or sale of Restricted Stock Units to Participants. Each such grant or sale may utilize any or all of the authorizations, and will be subject to all of the requirements, contained in the following provisions:
(a) Each such grant or sale will constitute the agreement by the Company to deliver Common Shares or cash, or a combination thereof, to the Participant in the future in consideration of the performance of services, but subject to the fulfillment of such conditions (which may include the achievement of Management Objectives) during the Restriction Period as the Committee may specify.
(b) If a grant of Restricted Stock Units specifies that the Restriction Period will terminate only upon the achievement of Management Objectives or that the Restricted Stock Units will be earned based on the achievement of Management Objectives, then, notwithstanding anything to the contrary contained in subparagraph (c) below, the applicable Restriction Period may not be a period of less than one year. 
(c) Each such grant or sale may be made without additional consideration or in consideration of a payment by such Participant that is less than the Market Value per Share at the Date of Grant.
(d) If the Restriction Period lapses only by the passage of time rather than the achievement of Management Objectives as provided in subparagraph (a) above, each such grant or sale will be subject to a Restriction Period of not less than one year.
(e) Notwithstanding anything to the contrary contained in this Plan, any grant or sale of Restricted Stock Units may provide for the earlier lapse or other modification of the Restriction Period, including in the event of the retirement, death or disability of a Participant, or in the event of a Change in Control.

7

EXHIBIT 4.4

(f) During the Restriction Period, the Participant will have no right to transfer any rights under his or her award and will have no rights of ownership in the Common Shares deliverable upon payment of the Restricted Stock Units and will have no right to vote them, but the Committee may, at the Date of Grant, authorize the payment of dividend equivalents on such Restricted Stock Units on either a current or deferred or contingent basis, either in cash or in additional Common Shares; provided , however , that dividend equivalents or other distributions on Common Shares underlying Restricted Stock Units with restrictions that lapse as a result of the achievement of Management Objectives will be deferred until and paid contingent upon the achievement of the applicable Management Objectives.
(g) Each grant or sale of Restricted Stock Units will specify the time and manner of payment of the Restricted Stock Units that have been earned. Each grant or sale will specify that the amount payable with respect thereto will be paid by the Company in Common Shares or cash, or a combination thereof.
(h) Each grant or sale of Restricted Stock Units will be evidenced by an Evidence of Award and will contain such terms and provisions, consistent with this Plan, as the Committee may approve.
8. Cash Incentive Awards, Performance Shares and Performance Units. The Committee may, from time to time and upon such terms and conditions as it may determine, authorize the granting of Cash Incentive Awards, Performance Shares and Performance Units. Each such grant may utilize any or all of the authorizations, and will be subject to all of the requirements, contained in the following provisions:
(a) Each grant will specify the number or amount of Performance Shares or Performance Units, or amount payable with respect to Cash Incentive Awards, to which it pertains, which number or amount may be subject to adjustment to reflect changes in compensation or other factors.
(b) The Performance Period with respect to each Cash Incentive Awards, Performance Share or Performance Unit will be such period of time (not less than one year) as will be determined by the Committee at the time of grant, which may be subject to earlier lapse or other modification, including in the event of the retirement, death or disability of a Participant, or in the event of a Change in Control.
(c) Any grant of Cash Incentive Awards, Performance Shares or Performance Units will specify Management Objectives which, if achieved, will result in payment or early payment of the award, and each grant may specify in respect of such specified Management Objectives a minimum acceptable level or levels of achievement and may set forth a formula for determining the number of Performance Shares or Performance Units, or amount payable with respect to Cash Incentive Awards, that will be earned if performance is at or above the minimum or threshold level or levels, or is at or above the target level or levels, but falls short of maximum achievement of the specified Management Objectives.
(d) Each grant will specify the time and manner of payment of Cash Incentive Awards, Performance Shares or Performance Units that have been earned. Any grant may specify that the amount payable with respect thereto may be paid by the Company in cash, in Common Shares, in Restricted Shares or Restricted Stock Units or in any combination thereof. 
(e) Any grant of Cash Incentive Awards, Performance Shares or Performance Units may specify that the amount payable or the number of Common Shares or Restricted Shares or Restricted Stock Units with respect thereto may not exceed a maximum specified by the Committee at the Date of Grant.
(f) The Committee may, at the Date of Grant of Performance Shares, provide for the payment of dividend equivalents to the holder thereof either in cash or in additional Common Shares, subject in all cases to deferral and payment on a contingent basis based on the Participant’s earning of the Performance Shares with respect to which such dividend equivalents are paid.
(g) Each grant of Cash Incentive Awards, Performance Shares or Performance Units will be evidenced by an Evidence of Award and will contain such other terms and provisions, consistent with this Plan, as the Committee may approve.
9. Other Awards.

8

EXHIBIT 4.4

(a) Subject to applicable law and the limit set forth in Section  3(c) of this Plan, the Committee may grant to any Participant such other awards that may be denominated or payable in, valued in whole or in part by reference to, or otherwise based on, or related to, Common Shares or factors that may influence the value of such shares, including, without limitation, convertible or exchangeable debt securities, other rights convertible or exchangeable into Common Shares, purchase rights for Common Shares, awards with value and payment contingent upon performance of the Company or specified Subsidiaries, affiliates or other business units thereof or any other factors designated by the Committee, and awards valued by reference to the book value of the Common Shares or the value of securities of, or the performance of specified Subsidiaries or affiliates or other business units of the Company. The Committee will determine the terms and conditions of such awards. Common Shares delivered pursuant to an award in the nature of a purchase right granted under this Section 9 will be purchased for such consideration, paid for at such time, by such methods, and in such forms, including, without limitation, Common Shares, other awards, notes or other property, as the Committee determines.
(b) Cash awards, as an element of or supplement to any other award granted under this Plan, may also be granted pursuant to this Section 9.
(c) The Committee may grant Common Shares as a bonus, or may grant other awards in lieu of obligations of the Company or a Subsidiary to pay cash or deliver other property under this Plan or under other plans or compensatory arrangements, subject to such terms as will be determined by the Committee in a manner that complies with Section 409A of the Code.
(d) If the earning or vesting of, or elimination of restrictions applicable to, an award granted under this Section 9 is based only on the passage of time rather than the achievement of Management Objectives, the period of time shall be no shorter than one year. If the earning or vesting of, or elimination of restrictions applicable to, awards granted under this Section  9 is based on the achievement of Management Objectives, the earning, vesting or restriction period may not terminate sooner than after one year.
(e) Notwithstanding anything to the contrary contained in this Plan, any grant of an award under this Section 9 may provide for the earning or vesting of, or earlier elimination of restrictions applicable to, such award, including in the event of the retirement, death or disability of the Participant, or in the event of a Change in Control.
10. Administration of this Plan.
(a) This Plan will be administered by the Committee. The Committee may from time to time delegate all or any part of its authority under this Plan to a subcommittee thereof. To the extent of any such delegation, references in this Plan to the Committee will be deemed to be references to such subcommittee.
(b) The interpretation and construction by the Committee of any provision of this Plan or of any Evidence of Award (or related documents) and any determination by the Committee pursuant to any provision of this Plan or of any such agreement, notification or document will be final and conclusive. No member of the Committee shall be liable for any such action or determination made in good faith. In addition, the Committee is authorized to take any action it determines in its sole discretion to be appropriate subject only to the express limitations contained in this Plan, and no authorization in any Plan Section or other provision of this Plan is intended or may be deemed to constitute a limitation on the authority of the Committee.
(c) To the extent permitted by law, the Committee may delegate to one or more of its members or to one or more officers of the Company, or to one or more agents or advisors, such administrative duties or powers as it may deem advisable, and the Committee, the subcommittee, or any person to whom duties or powers have been delegated as aforesaid, may employ one or more persons to render advice with respect to any responsibility the Committee, the subcommittee or such person may have under the Plan. The Committee may, by resolution, authorize one or more officers of the Company to do one or both of the following on the same basis as the Committee: (i) designate employees to be recipients of awards under this Plan; and (ii) determine the size of any such awards; provided , however , that (A) the Committee will not delegate such responsibilities to any such officer for awards granted to an employee who is an officer, Director, or more than 10% beneficial owner of any class of the Company’s equity securities that is registered pursuant to Section 12 of the Exchange Act, as determined by the Committee in accordance with Section 16 of the Exchange Act; (B) the resolution providing for such authorization 

9

EXHIBIT 4.4

sets forth the total number of Common Shares such officer(s) may grant; and (C) the officer(s) will report periodically to the Committee regarding the nature and scope of the awards granted pursuant to the authority delegated.
11. Adjustments. The Committee shall make or provide for such adjustments in the numbers of Common Shares covered by outstanding Option Rights, Appreciation Rights, Restricted Shares, Restricted Stock Units, Performance Shares and Performance Units granted hereunder and, if applicable, in the number of Common Shares covered by other awards granted pursuant to Section  9 hereof, in the Option Price and Base Price provided in outstanding Option Rights and Appreciation Rights, in the kind of shares covered thereby, in Cash Incentive Awards, and in other award terms, as the Committee, in its sole discretion, exercised in good faith, shall determine is equitably required to prevent dilution or enlargement of the rights of Participants or Optionees that otherwise would result from (a) any stock dividend, stock split, combination of shares, recapitalization or other change in the capital structure of the Company, (b) any merger, consolidation, spin-off, split-off, spin-out, split-up, reorganization, partial or complete liquidation or other distribution of assets, issuance of rights or warrants to purchase securities, or (c) any other corporate transaction or event having an effect similar to any of the foregoing. Moreover, in the event of any such transaction or event or in the event of a Change in Control, the Committee shall provide in substitution for any or all outstanding awards under this Plan such alternative consideration (including cash), if any, as it, in good faith, shall determine to be equitable in the circumstances and shall require in connection therewith the surrender of all awards so replaced in a manner that complies with Section 409A of the Code. In addition, for each Option Right or Appreciation Right with an Option Price or Base Price greater than the consideration offered in connection with any such transaction or event or Change in Control, the Committee may in its discretion elect to cancel such Option Right or Appreciation Right without any payment to the person holding such Option Right or Appreciation Right. The Committee shall also make or provide for such adjustments in the numbers of shares specified in Section  3 of this Plan as the Committee in its sole discretion, exercised in good faith, shall determine is appropriate to reflect any transaction or event described in this Section  11 ; provided , however , that any such adjustment to the number specified in Section  3(b) will be made only if and to the extent that such adjustment would not cause any Option Right intended to qualify as an Incentive Stock Option to fail to so qualify.
12. Change in Control. For purposes of this Plan, except as may be otherwise prescribed by the Committee in an Evidence of Award made under this Plan, a “Change in Control” will be deemed to have occurred upon the occurrence (after the Effective Date) of any of the following events:
(a) the Company is merged, consolidated or reorganized into or with another corporation or other legal person, and immediately after such merger, consolidation or reorganization less than a majority of the combined voting power of the then-outstanding securities of such corporation or person immediately after such transaction are held in the aggregate by the holders of Voting Stock (as that term is defined below) of the Company immediately prior to such transaction;
(b) the Company sells all or substantially all of its assets to any other corporation or other legal person, and less than a majority of the combined voting power of the then-outstanding securities of such corporation or person immediately after such sale are held in the aggregate by the holders of Voting Stock of the Company immediately prior to such sale;
(c) any person (as the term “person” is used in Section 13(d)(3) or Section 14(d)(2) of the Exchange Act) becomes the beneficial owner (as the term “beneficial owner” is defined under Rule 13d-3 or any successor rule or regulation promulgated under the Exchange Act) of securities representing 30% or more of the combined voting power of the then-outstanding securities entitled to vote generally in the election of directors of the Company (“Voting Stock”); or
(d) if during any period of two consecutive years, individuals who at the beginning of any such period constitute the Directors of the Company cease for any reason to constitute at least a majority thereof, provided, however, that for purposes of this subsection (d), each Director who is first elected, or first nominated for election by the Company’s shareholders by a vote of at least two-thirds of the Directors of the Company (or a committee thereof) then still in office who were Directors of the Company at the beginning of any such period will be deemed to have been a Director of the Company at the beginning of such period (but excluding for purposes of this proviso 

10

EXHIBIT 4.4

any individual whose initially becomes a Director as a result of either an actual or threatened election contest with respect to the election or removal of directors or other actual or threatened solicitation of proxies or consents by or on behalf of an individual, corporation, partnership, group, associate or other entity or person other than the Board).
Notwithstanding the foregoing provisions of this Section  12 , a “Change in Control” shall not be deemed to have occurred for purposes of the Plan solely because (i) the Company, (ii) an entity in which the Company directly or indirectly beneficially owns 50% or more of the voting securities or interest, or (iii) any Company-sponsored employee stock ownership plan or any other employee benefit plan of the Company, either files or becomes obligated to file a report or a proxy statement under or in response to Schedule 13D, Schedule 14D-l, Form 8-K or Schedule 14A (or any successor schedule, form or report or item therein) under the Exchange Act, disclosing beneficial ownership by it of shares of Voting Stock, whether in excess of 30% or otherwise, or because the Company reports that a change in control of the Company has or may have occurred or will or may occur in the future by reason of such beneficial ownership.
13. Detrimental Activity and Recapture Provisions. Any Evidence of Award may provide for the cancellation or forfeiture of an award or the forfeiture and repayment to the Company of any gain related to an award, or other provisions intended to have a similar effect, upon such terms and conditions as may be determined by the Committee from time to time, if a Participant, either (a) during employment or other service with the Company or a Subsidiary or (b) within a specified period after termination of such employment or service, shall engage in any detrimental activity. In addition, notwithstanding anything in this Plan to the contrary, any Evidence of Award may also provide for the cancellation or forfeiture of an award or the forfeiture and repayment to the Company of any gain related to an award, or other provisions intended to have a similar effect, upon such terms and conditions as may be required by the Committee or under Section 10D of the Exchange Act and any applicable rules or regulations promulgated by the Securities and Exchange Commission or any national securities exchange or national securities association on which the Common Shares may be traded.
14. Non U.S. Participants. In order to facilitate the making of any grant or combination of grants under this Plan, the Committee may provide for such special terms for awards to Participants who are foreign nationals or who are employed by the Company or any Subsidiary outside of the United States of America or who provide services to the Company under an agreement with a foreign nation or agency, as the Committee may consider necessary or appropriate to accommodate differences in local law, tax policy or custom. Moreover, the Committee may approve such supplements to or amendments, restatements or alternative versions of this Plan (including, without limitation, sub-plans) as it may consider necessary or appropriate for such purposes, without thereby affecting the terms of this Plan as in effect for any other purpose, and the Secretary or other appropriate officer of the Company may certify any such document as having been approved and adopted in the same manner as this Plan. No such special terms, supplements, amendments or restatements, however, will include any provisions that are inconsistent with the terms of this Plan as then in effect unless this Plan could have been amended to eliminate such inconsistency without further approval by the shareholders of the Company.
15. Transferability.
(a) Except as otherwise determined by the Committee, no Option Right, Appreciation Right, Restricted Shares, Restricted Stock Unit, Performance Share, Performance Unit, Cash Incentive Award, award contemplated by Section 9 of this Plan or dividend equivalents paid with respect to awards made under this Plan will be transferable by the Participant except by will or the laws of descent and distribution. In no event will any such award granted under the Plan be transferred for value. Except as otherwise determined by the Committee, Option Rights and Appreciation Rights will be exercisable during the Participant’s lifetime only by him or her or, in the event of the Participant’s legal incapacity to do so, by his or her guardian or legal representative acting on behalf of the Participant in a fiduciary capacity under state law or court supervision.
(b) The Committee may specify at the Date of Grant that part or all of the Common Shares that are (i) to be issued or transferred by the Company upon the exercise of Option Rights or Appreciation Rights, upon the termination of the Restriction Period applicable to Restricted Stock Units or upon payment under any grant of Performance Shares or Performance Units or (ii) no longer subject to the substantial risk of forfeiture and restrictions on transfer referred to in Section  6 of this Plan, will be subject to further restrictions on transfer.

11

EXHIBIT 4.4

16. Withholding Taxes. To the extent that the Company is required to withhold federal, state, local or foreign taxes in connection with any payment made or benefit realized by a Participant or other person under this Plan, and the amounts available to the Company for such withholding are insufficient, it will be a condition to the receipt of such payment or the realization of such benefit that the Participant or such other person make arrangements satisfactory to the Company for payment of the balance of such taxes required to be withheld, which arrangements (in the discretion of the Committee) may include relinquishment of a portion of such benefit. If a Participant’s benefit is to be received in the form of Common Shares, then, unless otherwise determined by the Committee, the Company will withhold from the shares required to be delivered to the Participant, Common Shares having a value equal to the amount required to be withheld under applicable income and employment tax laws. The shares used for tax withholding will be valued at an amount equal to the market value of such Common Shares on the date the benefit is to be included in the Participant’s income. In no event will the market value of the Common Shares to be withheld and delivered pursuant to this Section to satisfy applicable withholding obligations exceed the minimum amount required to be withheld, unless (i) an additional amount can be withheld and not result in adverse accounting consequences, (ii) such additional withholding amount is authorized by the Committee, and (iii) the total amount withheld does not exceed the Participant’s estimated tax obligations attributable to the applicable transaction. Participants will also make such arrangements as the Committee may require for the payment of any withholding obligation that may arise in connection with the disposition of Common Shares acquired upon the exercise of Option Rights.
17. Compliance with Section 409A of the Code.
(a) To the extent applicable, it is intended that this Plan and any grants made hereunder comply with the provisions of Section 409A of the Code, so that the income inclusion provisions of Section 409A(a)(1) of the Code do not apply to the Participants. This Plan and any grants made hereunder will be administered in a manner consistent with this intent. Any reference in this Plan to Section 409A of the Code will also include any regulations or any other formal guidance promulgated with respect to such Section by the U.S. Department of the Treasury or the Internal Revenue Service.
(b) Neither a Participant nor any of a Participant’s creditors or beneficiaries will have the right to subject any deferred compensation (within the meaning of Section 409A of the Code) payable under this Plan and grants hereunder to any anticipation, alienation, sale, transfer, assignment, pledge, encumbrance, attachment or garnishment. Except as permitted under Section 409A of the Code, any deferred compensation (within the meaning of Section 409A of the Code) payable to a Participant or for a Participant’s benefit under this Plan and grants hereunder may not be reduced by, or offset against, any amount owing by a Participant to the Company or any of its Subsidiaries.
(c) If, at the time of a Participant’s separation from service (within the meaning of Section 409A of the Code), (i) the Participant will be a specified employee (within the meaning of Section 409A of the Code and using the identification methodology selected by the Company from time to time) and (ii) the Company makes a good faith determination that an amount payable hereunder constitutes deferred compensation (within the meaning of Section 409A of the Code) the payment of which is required to be delayed pursuant to the six-month delay rule set forth in Section 409A of the Code in order to avoid taxes or penalties under Section 409A of the Code, then the Company will not pay such amount on the otherwise scheduled payment date but will instead pay it, without interest, on the fifth business day of the seventh month after such separation from service.
(d) Solely with respect to any award that constitutes nonqualified deferred compensation subject to Section 409A of the Code and that is payable on account of a Change in Control (including any installments or stream of payments that are accelerated on account of a Change in Control), a Change in Control shall occur only if such event also constitutes a “change in the ownership,” “change in effective control,” and/or a “change in the ownership of a substantial portion of assets” of the Company as those terms are defined under Treasury Regulation §1.409A-3(i)(5), but only to the extent necessary to establish a time and form of payment that complies with Section 409A of the Code, without altering the definition of Change in Control for any purpose in respect of such award.

12

EXHIBIT 4.4

(e) Notwithstanding any provision of this Plan and grants hereunder to the contrary, in light of the uncertainty with respect to the proper application of Section 409A of the Code, the Company reserves the right to make amendments to this Plan and grants hereunder as the Company deems necessary or desirable to avoid the imposition of taxes or penalties under Section 409A of the Code. In any case, a Participant will be solely responsible and liable for the satisfaction of all taxes and penalties that may be imposed on a Participant or for a Participant’s account in connection with this Plan and grants hereunder (including any taxes and penalties under Section 409A of the Code), and neither the Company nor any of its affiliates will have any obligation to indemnify or otherwise hold a Participant harmless from any or all of such taxes or penalties.

18. Amendments.
(a) The Board may at any time and from time to time amend this Plan in whole or in part; provided , however , that if an amendment to this Plan (i) would materially increase the benefits accruing to participants under this Plan, (ii) would materially increase the number of securities which may be issued under this Plan, (iii) would materially modify the requirements for participation in this Plan, or (iv) must otherwise be approved by the shareholders of the Company in order to comply with applicable law or the rules of the Nasdaq Stock Market or, if the Common Shares are not traded on the Nasdaq Stock Market, the principal national securities exchange upon which the Common Shares are traded or quoted, then, such amendment will be subject to shareholder approval and will not be effective unless and until such approval has been obtained.
(b) Except in connection with a corporate transaction or event described in Section  11 of this Plan, the terms of outstanding awards may not be amended to reduce the Option Price of outstanding Option Rights or the Base Price of outstanding Appreciation Rights, or cancel outstanding Option Rights or Appreciation Rights in exchange for cash, other awards or Option Rights or Appreciation Rights with an Option Price or Base Price, as applicable, that is less than the Option Price of the original Option Rights or Base Price of the original Appreciation Rights, as applicable, without shareholder approval. This Section 18(b) is intended to prohibit the repricing of “underwater” Option Rights and Appreciation Rights and will not be construed to prohibit the adjustments provided for in Section 11 of this Plan. Notwithstanding any provision of this Plan to the contrary, this Section 18(b) may not be amended without approval by the Company’s shareholders.
(c) If permitted by Section 409A of the Code, but subject to the paragraph that follows, including in the case of termination of employment by reason of death, disability or retirement, or in the case of unforeseeable emergency or other special circumstances or in the event of a Change in Control, to the extent a Participant holds an Option Right or Appreciation Right not immediately exercisable in full, or any Restricted Shares as to which the substantial risk of forfeiture or the prohibition or restriction on transfer has not lapsed, or any Restricted Stock Units as to which the Restriction Period has not been completed, or any Cash Incentive Awards, Performance Shares or Performance Units which have not been fully earned, or any other awards made pursuant to Section  9 subject to any vesting schedule or transfer restriction, or who holds Common Shares subject to any transfer restriction imposed pursuant to Section  15(b) of this Plan, the Committee may, in its sole discretion, accelerate the time at which such Option Right, Appreciation Right or other award may be exercised or the time at which such substantial risk of forfeiture or prohibition or restriction on transfer will lapse or the time when such Restriction Period will end or the time at which such Cash Incentive Awards, Performance Shares or Performance Units will be deemed to have been fully earned or the time when such transfer restriction will terminate or may waive any other limitation or requirement under any such award.
(d) Subject to Section 18(b) hereof, the Committee may amend the terms of any award theretofore granted under this Plan prospectively or retroactively. Subject to Section 11 above, no such amendment will impair the rights of any Participant without his or her consent. The Board may, in its discretion, terminate this Plan at any time. Termination of this Plan will not affect the rights of Participants or their successors under any awards outstanding hereunder and not exercised in full on the date of termination.

13

EXHIBIT 4.4

19. Governing Law. This Plan and all grants and awards and actions taken hereunder will be governed by and construed in accordance with the internal substantive laws of the State of Ohio.
20. Effective Date/Termination. This Plan will be effective as of the Effective Date. No grants will be made on or after the Effective Date under the Predecessor Plans, except that outstanding awards granted under the Predecessor Plan will continue unaffected following the Effective Date. No grant will be made under this Plan after the tenth anniversary of the Effective Date, but all grants made on or prior to such date will continue in effect thereafter subject to the terms thereof and of this Plan. For clarification purposes, the terms and conditions of this Plan shall not apply to or otherwise impact previously granted and outstanding awards under the Predecessor Plans, as applicable.
21. Miscellaneous Provisions.
(a) The Company will not be required to issue any fractional Common Shares pursuant to this Plan. The Committee may provide for the elimination of fractions or for the settlement of fractions in cash.
(b) This Plan will not confer upon any Participant any right with respect to continuance of employment or other service with the Company or any Subsidiary, nor will it interfere in any way with any right the Company or any Subsidiary would otherwise have to terminate such Participant’s employment or other service at any time.
(c) Except with respect to Section 21(e) , to the extent that any provision of this Plan would prevent any Option Right that was intended to qualify as an Incentive Stock Option from qualifying as such, that provision will be null and void with respect to such Option Right. Such provision, however, will remain in effect for other Option Rights and there will be no further effect on any provision of this Plan.
(d) No award under this Plan may be exercised by the holder thereof if such exercise, and the receipt of cash or stock thereunder, would be, in the opinion of counsel selected by the Company, contrary to law or the regulations of any duly constituted authority having jurisdiction over this Plan.
(e) Absence on leave approved by a duly constituted officer of the Company or any of its Subsidiaries will not be considered interruption or termination of service of any employee for any purposes of this Plan or awards granted hereunder.
(f) No Participant will have any rights as a shareholder with respect to any shares subject to awards granted to him or her under this Plan prior to the date as of which he or she is actually recorded as the holder of such shares upon the stock records of the Company.
(g) The Committee may condition the grant of any award or combination of awards authorized under this Plan on the surrender or deferral by the Participant of his or her right to receive a cash bonus or other compensation otherwise payable by the Company or a Subsidiary to the Participant.
(h) Except with respect to Option Rights and Appreciation Rights, the Committee may permit Participants to elect to defer the issuance of Common Share under the Plan pursuant to such rules, procedures or programs as it may establish for purposes of this Plan and which are intended to comply with the requirements of Section 409A of the Code. The Committee also may provide that deferred issuances and settlements include the payment or crediting of dividend equivalents or interest on the deferral amounts.
(i) If any provision of this Plan is or becomes invalid, illegal or unenforceable in any jurisdiction, or would disqualify this Plan or any award under any law deemed applicable by the Committee, such provision will be construed or deemed amended or limited in scope to conform to applicable laws or, in the discretion of the Committee, it will be stricken and the remainder of this Plan will remain in full force and effect. Notwithstanding anything in this Plan or an Evidence of Award to the contrary, nothing in this Plan or in an Evidence of Award prevents a Participant from providing, without prior notice to the Company, information to governmental authorities regarding possible legal violations or otherwise testifying or participating in any investigation or proceeding by any governmental authorities regarding possible legal violations, and for purpose of clarity, a Participant is not prohibited from providing information voluntarily to the Securities and Exchange Commission pursuant to Section 21F of the Exchange Act.

14

EXHIBIT 4.4

22. Stock-Based Awards in Substitution for Option Rights or Awards Granted by Other Company. Notwithstanding anything in this Plan to the contrary:
(a) Awards may be granted under this Plan in substitution for or in conversion of, or in connection with an assumption of, stock options, stock appreciation rights, restricted stock, restricted stock units or other stock or stock-based awards held by awardees of an entity engaging in a corporate acquisition or merger transaction with the Company or any Subsidiary. Any conversion, substitution or assumption will be effective as of the close of the merger or acquisition, and, to the extent applicable, will be conducted in a manner that complies with Section 409A of the Code. The awards so granted may reflect the original terms of the awards being assumed or substituted or converted for and need not comply with other specific terms of this Plan, and may account for Common Shares substituted for the securities covered by the original awards and the number of shares subject to the original awards, as well as any exercise or purchase prices applicable to the original awards, adjusted to account for differences in stock prices in connection with the transaction.
(b) In the event that a company acquired by the Company or any Subsidiary or with which the Company or any Subsidiary merges has shares available under a pre-existing plan previously approved by stockholders and not adopted in contemplation of such acquisition or merger, the shares available for grant pursuant to the terms of such plan (as adjusted, to the extent appropriate, to reflect such acquisition or merger) may be used for awards made after such acquisition or merger under the Plan; provided , however , that awards using such available shares may not be made after the date awards or grants could have been made under the terms of the pre-existing plan absent the acquisition or merger, and may only be made to individuals who were not employees or directors of the Company or any Subsidiary prior to such acquisition or merger.
(c) Any Common Shares that are issued or transferred by, or that are subject to any awards that are granted by, or become obligations of, the Company under Sections 22(a) or 22(b) above will not reduce the Common Shares available for issuance or transfer under the Plan or otherwise count against the limits contained in Section 3 of the Plan. In addition, no Common Shares that are issued or transferred by, or that are subject to any awards that are granted by, or become obligations of, the Company under Sections 22(a) or 22(b) above will be added to the aggregate plan limit contained in Section 3 of the Plan.
 

15

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