Document:

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                                     LEASE

                               5781 Van Allen Way
                              Carlsbad, California

                                    Landlord

                       CalWest Industrial Properties, LLC

                                     Tenant

                             Invitrogen Corporation

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                         SINGLE TENANT INDUSTRIAL LEASE
                                 REFERENCE PAGE

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<S>                                     <C>
BUILDING:                               5781 Van Allen Way
                                        Carlsbad, California 92008-7331

LANDLORD:                               CalWest Industrial Properties, LLC

LANDLORD'S ADDRESS:                     2121 Palomar Airport Road, Suite 100
                                        Carlsbad, California 92009

LEASE REFERENCE DATE:                   May 31, 2001

TENANT:                                 Invitrogen Corporation

TENANT'S ADDRESS:                       1620 Faraday Avenue
                                        Carlsbad, California 92008

BUILDING RENTABLE AREA:                 Approximately 320,025 sq. ft.

USE:                                    General office (including an
                                        information/computer room),
                                        manufacturing, research and development,
                                        warehousing, distribution and any
                                        ancillary uses related to such purposes,
                                        as permitted under existing zoning and
                                        applicable laws, regulations,
                                        ordinances and  recorded covenants

COMMENCEMENT DATE:                      November 1, 2001

TERMINATION DATE:                       October 31, 2011

TERM OF LEASE:                          10 years, beginning on the Commencement
                                        Date and ending on the
                                        Termination Date (unless sooner
                                        terminated or extended pursuant to the
                                        Lease)

INITIAL ANNUAL RENT (Arcicle 3):        $1,403,109.12; See Addendum

INITIAL MONTHLY INSTALLMENT OF
ANNUAL RENT (Article 3):                $116,925.76; See Addendum

ASSIGNMENT/SUBLETTING FEE:              $500.00

SECURITY DEPOSIT:                       $0.00

REAL ESTATE BROKERS
DUE COMMISSION:                         CB Richard Ellis, Inc. (Landlord's
                                        Broker) and
                                        San Diego Commercial Real Estate
                                        Services (Tenant's Broker)
</Table>

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     The Reference Page information is incorporated into and made a part of the
Lease. In the event of any conflict between any Reference Page information and
the Lease, the Lease shall control. This Lease includes Exhibits A, B, C, D-1
and D-2, and each of which are made a part of this Lease.

LANDLORD:                                            TENANT:

CalWest Industrial Properties, LLC,                  Invitrogen Corporation,
a California limited liability company               a Delaware corporation

By: RREEF America, L.L.C.,                           By: /s/ [ILLEGIBLE]
                                                         -----------------------
a Delaware limited liability company                 Title: Vice President
                                                            --------------------
By: /s/ [ILLEGIBLE]                                  By: /s/ [ILLEGIBLE]
    ---------------------------------                    --------------------
Title: VP - Authorized Representative                Title: [ILLEGIBLE]
       ------------------------------                       -------------------
Dated: 6/11/01                                       Dated: June 6, 2001
       ---------------------                                --------------------

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                               TABLE OF CONTENTS

<Table>
<Caption>
Article                                                                     Page
<S>                                                                           <C>
1. USE AND RESTRICTIONS ON USE ............................................    1

2. TERM ...................................................................    1

3. RENT ...................................................................    2

4. TAXES ..................................................................    2

5. SECURITY DEPOSIT .......................................................    3

6. ALTERATIONS ............................................................    3

7. REPAIR .................................................................    3

8. LIENS ..................................................................    4

9. ASSIGNMENT AND SUBLETTING ..............................................    4

10. INDEMNIFICATION .......................................................    5

11. INSURANCE .............................................................    6

12. WAIVER OF SUBROGATION .................................................    6

13. SERVICES AND UTILITIES ................................................    6

14. HOLDING OVER ..........................................................    6

15. SUBORDINATION .........................................................    7

16. REENTRY BY LANDLORD ...................................................    7

17. DEFAULT ...............................................................    7

18. REMEDIES ..............................................................    8

19. TENANT'S BANKRUPTCY OR INSOLVENCY .....................................    9

20. QUIET ENJOYMENT .......................................................   10

21. DAMAGE BY FIRE, ETC ...................................................   10

22. EMINENT DOMAIN ........................................................   11

23. SALE BY LANDLORD ......................................................   11

24. ESTOPPEL CERTIFICATES .................................................   12
</Table>

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25. SURRENDER OF PREMISES .................................................   12

26. NOTICES ...............................................................   12

27. TAXES PAYABLE BY TENANT ...............................................   13

28. DEFINED TERMS AND HEADINGS ............................................   13

29. AUTHORITY .............................................................   13

30. COMMISSIONS ...........................................................   13

31. TIME AND APPLICABLE LAW ...............................................   14

32. SUCCESSORS AND ASSIGNS ................................................   14

33. ENTIRE AGREEMENT ......................................................   14

34. EXAMINATION NOT OPTION ................................................   14

35. RECORDATION ...........................................................   14

36. LIMITATION OF LANDLORD'S LIABILITY ....................................   14
</Table>

    EXHIBIT A - PREMISES
    EXHIBIT B - INITIAL ALTERATIONS
    EXHIBIT C - ADDENDUM TO LEASE
    EXHIBITS D-1 AND D-2 - CONFIDENTIALITY AGREEMENTS

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                                      LEASE

          By this Lease Landlord Leases to Tenant and Tenant leases from
     Landlord the Building, together with parking areas, walkways, driveways and
     landscaped areas related thereto, as set forth and described on the
     References Page (the "Premises"). The Reference Page, including all terms
     defined thereon, is incorporated as part of this Lease.

     1. USE AND RESTRICTIONS ON USE.

1.1  The Premises are to be used solely for the purposes stated on the
     Reference Page. Tenant shall not do or permit anything to be done in or
     about the Premises which will in any way obstruct or interfere with the
     rights of other tenants or occupants of the Building or injure, annoy, or
     disturb them or allow the Premises to be used for any improper, immoral,
     unlawful, or objectionable purpose.* Tenant shall not do, permit or suffer
     in, on, or about the Premises the sale of any alcoholic liquor without the
     written consent of Landlord first obtained, or the commission of any waste
     to the Premises. Tenant shall comply with all governmental laws, ordinances
     and regulations (collectively, "Laws") applicable to the use of the
     Premises and its occupancy and shall promptly comply with all governmental
     orders and directions for the correction, prevention and abatement of any
     violations in or upon, or in connection with, the Premises, all at Tenant's
     sole expense. See Addendum.

----------
* See Section 1.3 regarding the Roof Lease.

1.2  Except as otherwise specifically provided in this Lease, Tenant shall
     not, and shall not direct, suffer or permit any of its agents, contractors,
     employees, licensees or invitees to at any time handle, use, manufacture,
     store or dispose of in or about the Premises or the Building any
     (collectively "Hazardous Materials") flammables, explosives, radioactive
     materials, hazardous wastes or materials, toxic wastes or materials, or
     other similar substances, petroleum products or derivatives or any
     substance subject to regulation by or under any federal, state and local
     laws and ordinances relating to the protection of the environment or the
     keeping, use or disposition of environmentally hazardous materials,
     substances, or wastes, presently in effect or hereafter adopted, all
     amendments to any of them, and all rules and regulations issued pursuant to
     any of such laws or ordinances (collectively "Environmental Laws"), nor
     shall Tenant suffer or permit any Hazardous Materials to be used in any
     manner not fully in compliance with all Environmental Laws, in the Premises
     or the Building and appurtenant land or allow the environment to become
     contaminated with any Hazardous Materials. Notwithstanding the foregoing,
     Tenant may handle, store, use or dispose of products containing small
     quantities of Hazardous Materials (such as aerosol cans containing
     insecticides, toner for copiers, paints, paint remover and the like) to the
     extent customary and necessary for the use of the Premises for general
     office purposes; provided that Tenant shall always handle, store, use, and
     dispose of any such Hazardous Materials in a safe and lawful manner and
     never allow such Hazardous Materials to contaminate the Premises, Building
     and appurtenant land or the environment. Tenant shall protect, defend,
     indemnify and hold each and all of the Landlord Entities (as defined in
     Article 28) harmless from and against any and all loss, claims, liability
     or costs (including court costs and attorney's fees) incurred by reason of
     any actual or asserted failure of Tenant to fully comply with all
     applicable Environmental Laws, or the presence, handling, use or
     disposition in or from the Premises of any Hazardous Materials (even though
     permissible under all applicable Environmental Laws or the provisions of
     this Lease caused by Tenant or its employees, agents, contractors or
     invitees ), or by reason of any actual or asserted failure of Tenant to
     keep, observe, or perform any provision of this Section 1.2.

     See Addendum

     2. TERM

          2.1 The Term of this Lease shall begin on the date ("Commencement
     Date") which shall be the later of the Commencement Date as shown on the
     Reference Page and the date that Landlord shall tender possession of the
     Premises to Tenant. If requested in writing by either Landlord or Tenant,
     Landlord and Tenant shall execute a memorandum setting forth the actual
     Commencement Date and Termination Date.

               2.1.1 Tenant agrees that in the event of the inability of
     Landlord to deliver possession of the Premises on the Commencement Date,
     Landlord shall not be liable for any damage resulting from such inability.

     See Addendum

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     2.2 In the event Landlord shall permit Tenant to occupy the Premises prior
to the Commencement Date, such occupancy shall be subject to all the provisions
of this Lease. Said early possession shall not advance the Termination Date.

3. RENT.

     3.1 Tenant agrees to pay Landlord the Annual Rent in effect from time to
time by paying the Monthly Installment of Rent then in effect on or before the
first day of each full calendar month during the Term, except that the rent for
November 2001 shall be paid upon the execution of this Lease. The Monthly
Installment of Rent in effect at any time shall be one-twelfth of the Annual
Rent in effect at such time. Rent for any period during the Term which is less
than a full month shall be a prorated portion of the Monthly Installment of Rent
based upon a thirty (30) day month. Said rent shall be paid to Landlord, without
deduction or offset and without notice or demand, at the Landlord's address, as
set forth on the Reference Page, or to such other person or at such other place
as Landlord may from time to time designate in writing.

     3.2 Tenant recognizes that the late payment of any rent or other sum due
under this Lease will result in administrative expense to Landlord, the extent
of which additional expense is extremely difficult and economically impractical
to ascertain. Tenant therefore agrees that if rent or any other sum is not paid
within 3 days after Tenant receives notice that rent or such sum is due and
payable pursuant to this Lease, a late charge shall be imposed in an amount
equal to the greater of: (a) Fifty Dollars($50.00), or (b) a sum equal to three
percent (3%) per month of the unpaid rent or other payment. The amount of the
late charge to be paid by Tenant shall be reassessed and added to Tenant's
obligation for each successive monthly period until paid. The provisions of this
Section 3.2 in no way relieve Tenant of the obligation to pay rent or other
payments on or before the date on which they are due, nor do the terms of this
Section 3.2 in any way affect Landlord's remedies pursuant to Article 18 in the
event said rent or other payment is unpaid after date due.

4. TAXES

     4.1 Tenant shall pay as additional rent all Taxes incurred on the Building
during the Term. Taxes shall be defined as real estate taxes and any other
taxes, charges and assessments which are levied with respect to the Building or
the land appurtenant to the Building, or with respect to any improvements,
fixtures and equipment or other property of Landlord, real or personal, located
in the Building and used in connection with the operation of the Building and
said land, any payments to any ground lessor in reimbursement of tax payments
made by such lessor; and all fees, expenses and costs incurred by Landlord in
investigating, protesting, contesting or in any way seeking to reduce or avoid
increase in any assessments, levies or the tax rate pertaining to any Taxes to
be paid by Landlord in any Lease Year during the Term. Taxes shall not include
any corporate franchise, or estate, inheritance or net income tax, or tax
imposed upon any transfer by Landlord of its interest in this Lease or the
Building.

     4.2 Prior to the actual determination thereof, Landlord may from time to
time estimate Tenant's liability for Taxes under Section 4.1, Article 6 and
Article 27 for the lease year or portion thereof. Landlord will give Tenant
written notification of the amount of such estimate and Tenant agrees that it
will pay, by increase of its Monthly Installments of Rent due in such lease
year, additional rent in the amount of such estimate. Any such increased rate of
Monthly Installments of Rent pursuant to this Section 4.2 shall remain in effect
until further written notification to Tenant pursuant hereto.

     4.3 When the above mentioned actual determination of Tenant's liability for
Taxes is made in any lease year and when Tenant is so notified in writing, then:

         4.3.1 If the total additional rent Tenant actually paid pursuant to
Section 4.2 is more than Tenant's liability for Taxes, then Landlord shall
refund the difference within 30 days.

     4.4 If the Commencement Date is other than January 1 or if the Termination
Date is other than December 31, Tenant's liability for Taxes for the year in
which said Date occurs shall be prorated based upon a three hundred sixty-five
(365) day year.

     4.5 Even though the Term has expired and Tenant has vacated the premises,
when the final determination is made of Tenant's liability for Taxes for the
year in which the Lease terminated, Tenant shall pay any difference due over the
estimated taxes paid; and conversely any overpayment, less any amounts due
Landlord under this Lease, shall be rebated to Tenant.

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6. ALTERATIONS.

     6.1 Except for those, if any, specifically provided for in Exhibit B to
this Lease, Tenant shall not make or suffer to be made any alterations,
additions, or improvements, including, but not limited to, the attachment of any
fixtures or equipment in, on, or to the Premises or any part thereof or the
making of any improvements as required by Article 7, without the prior written
consent of Landlord which consent shall not be unreasonably withheld,
conditioned or delayed. When applying for such consent, Tenant shall, if
requested by Landlord, furnish complete plans and specifications for such
alterations, additions and improvements.

     See Addendum.

     6.2 In the event Landlord consents to the making of any such alteration,
addition or improvement by Tenant, the same shall be made using Tenant's
contractor.

     6.4

     See Addendum.

     6.5 Tenant shall pay in addition to any sums due pursuant to Article 4, any
increase in real estate taxes attributable to any such alteration, addition or
improvement for so long, during the Term, as such increase is ascertainable; at
Landlord's election said sums shall be paid in the same way as sums due under
Article 4.

7. REPAIR

     See Addendum.

     7.1 By taking possession of the Premises, Tenant accepts them as being in
good order, condition and repair and in the condition in which Landlord is
obligated to deliver them. It is hereby understood and agreed that no
representations respecting the condition of the Premises or the Building have
been made by Landlord to Tenant, except as specifically set forth in this Lease.

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     7.2 Subject to Landlord's duties set forth in Section 7.1 above, Tenant
shall at its own cost and expense keep and maintain all parts of the Premises in
good condition, promptly making all necessary repairs and replacements, whether
ordinary or extraordinary, with materials and workmanship of the same character,
kind and quality as the original (including, but not limited to, repair and
replacement of all fixtures installed by Tenant, water heaters serving the
Premises, windows, glass and plate glass, doors, exterior stairs, skylights, any
special office entries, interior walls and finish work, floors and floor
coverings, heating and air conditioning systems, electrical systems and
fixtures, sprinkler systems, dock boards, truck doors, dock bumpers, driveways,
rail tracks serving the Premises, plumbing work and fixtures, and performance of
regular removal of trash and debris). Tenant as part of its obligations
hereunder shall keep the Premises in a clean and sanitary condition. Tenant
will, as far as possible keep all such parts of the Premises from deterioration
due to ordinary wear and from falling temporarily out of repair, and upon
termination of this Lease in any way Tenant will yield up the Premises to
Landlord in good condition and repair, loss by fire or other casualty excepted
(but not excepting any damage to glass). See Section 25.

     7.3 Except as set forth in this Section 7.3 and as provided in Article 21,
there shall be no abatement of rent and no liability of Landlord by reason of
any injury to or interference with Tenant's business arising from the making of
any repairs, alterations or improvements in or to any portion of the Building or
the Premises or to fixtures, appurtenances and equipment in the Building.

     See Addendum.

     7.4 Tenant shall, at its own cost and expense, enter into a regularly
scheduled preventive maintenance/service contract with a maintenance contractor
approved by Landlord for servicing all heating and air conditioning systems and
equipment serving the Premises (and a copy thereof shall be furnished to
Landlord). The service contract must include all services suggested by the
equipment manufacturer in the operation/maintenance manual and must become
effective within thirty (30) days of the date Tenant takes possession of the
Premises. Landlord may, upon notice to Tenant, enter into such a maintenance/
service contract on behalf of Tenant, or perform the work and in either case,
charge Tenant the cost thereof along with a reasonable amount for Landlord's
overhead.

     7.5 Tenant hereby waives and releases its right to make repairs at
Landlord's expense under Section 1941 and 1942 of the California Civil Code or
under any similar law, statute or ordinance now or hereafter in effect.
See Section 7.1.

     See Addendum.

8. LIENS.

Tenant shall keep the Premises, the Building and appurtenant land and Tenant's
leasehold interest in the Premises free from any liens arising out of any
services, work or materials performed, furnished, or contracted for by Tenant,
or obligations incurred by Tenant. In the event that Tenant shall not, within
(30) days following the imposition of any such lien, either cause the same to be
released of record or provide Landlord with insurance against the same issued by
a major title insurance company or such other protection against the same as
Landlord shall accept, Landlord shall have the right to cause the same to be
released by such means as it shall deem proper, including payment of the claim
giving rise to such lien. All such sums paid by Landlord and all expenses
incurred by it in connection therewith shall be considered additional rent and
shall be payable to it by Tenant on demand. Landlord shall have the right at all
times to post and keep posted on the Premises any notices permitted or required
by law, or that Landlord shall deem proper, for the protection of Landlord, the
Premises, the Building, and any other party having an interest therein, from
mechanics' and materialmen's liens, and Tenant shall give to Landlord at least
five business days' prior notice of commencement of any construction on the
Premises.

9. ASSIGNMENT AND SUBLETTING

     9.1 Tenant shall not have the right to assign or pledge this Lease or to
sublet the whole or any part of the Premises whether voluntarily or by operation
of law, or permit the use or occupancy of the Premises by anyone other than
Tenant, and shall not make, suffer or permit such assignment, subleasing or
occupancy without the prior written consent of Landlord (such consent shall not
be unreasonably withheld, conditioned or delayed) and said restrictions shall be
binding upon any and all assignees of the Lease and subtenants of the Premises.
In the event Tenant desires to sublet, or permit such occupancy of, the
Premises, or any portion thereof, or assign this Lease, Tenant shall give
written notice thereof to Landlord at lease thirty (30) days but no more than
one hundred eighty (180) days prior to the proposed subtenant or assignee, the
relevant terms of any sublease or assignment and copies of financial reports and
other relevant financial reports and other relevant financial information of the
proposed subtenant or assignee.

     See Addendum.

     9.2 Notwithstanding any assignment or subletting, permitted or otherwise,
Tenant shall at all times remain directly, primarily and fully responsible and
liable for the payment of the rent specified in this Lease and for compliance
with all of its other obligations under the terms, provisions and covenants of
this Lease. Upon the occurrence of an Event of Default, if the Premises or any
part of them are then assigned or sublet, Landlord, in addition to any other
remedies provided in this Lease or provided by law, may, at its option, collect
directly from

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such assignee or subtenant all rents due and becoming due to Tenant under such
assignment or sublease and apply such rent against any sums due to Landlord from
Tenant under this Lease, and no such collection shall be construed to constitute
a novation or release of Tenant from the further performance of Tenant's
obligations under this Lease.

     9.3

     9.4

     9.5 Notwithstanding any other provision hereof, Tenant shall have no right
to make (and Landlord shall have the absolute right to refuse consent to) any
assignment of this Lease or sublease of any portion of the Premises if at the
time of either Tenant's notice of the proposed assignment or sublease or the
proposed commencement date thereof, there shall exist any uncured default of
Tenant or matter which will become a default of Tenant with passage of time
unless cured; or if the proposed assignee or sublessee is a governmental agency;
(d) is incompatible with the character of occupancy of the Building; or (e)
would subject the Premises to a use which would; involve a violation of Section
1.2.

     9.6 Upon any request to assign or sublet, Tenant will pay to Landlord the
Assignment/Subletting Fee regardless of whether Landlord shall consent to,
refuse consent, or determine that Landlord's consent is not required for, such
assignment, pledge or sublease. Any purported sale, assignment, mortgage,
transfer of this Lease of subletting which does not comply with the provisions
of this Article 9 shall be void.

     9.7

     See Addendum.

10. INDEMNIFICATION.

None of the Landlord Entities shall be liable and Tenant hereby waives all
claims against them for any damage to any property or any injury to any person
in or about the Premises by or from any cause whatsoever (including without
limiting the foregoing, rain or water leakage of any character from the roof,
windows, walls, basement, pipes, plumbing works or appliances, the Premises not
being in good condition or repair, gas, fire, oil electricity or

                                       5
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theft), except to the extent caused by or arising from the negligence or willful
misconduct of Landlord or its agents, employees or contractors. Tenant shall
protect, indemnify and hold the Landlord Entities harmless from and against any
and all loss, claims, liability or costs (including court costs and attorney's
fees) incurred by reason of (a) any damage to any property (including but not
limited to property of any Landlord Entity) or any injury (including but not
limited to death) to any person occurring in, on or about the Premises to the
extent that such injury or damage shall be caused by or arise from any actual or
alleged act, neglect, fault, or omission by or of Tenant, its agents, servants,
employees, invitees, or visitors to meet any standards imposed by any duty with
respect to the injury or damage; (b) the conduct or management of any work or
thing whatsoever done by the Tenant in or about the Premises or from
transactions of the Tenant concerning the Premises; (c) Tenant's failure to
comply with any and all governmental laws, ordinances and regulations applicable
to the condition or use of the Premises or its occupancy; or (d) any breach or
default on the part of Tenant in the performance of any covenant or agreement on
the part of the Tenant to be performed pursuant to this Lease. The provisions of
this Article shall survive the termination of this Lease with respect to any
claims or liability accruing prior to such termination.

     See Addendum.

11. INSURANCE

     11.1 Tenant shall keep in force throughout the Term: (a) a Commercial
General Liability insurance policy or policies to protect the Landlord Entities
against any liability to the public or to any invitee of Tenant or a Landlord
Entity incidental to the use of or resulting from any accident occurring in or
upon the Premises with a limit of not less than $ 1,000,000 per occurrence and
not less than $2,000,000 in the annual aggregate, covering bodily injury and
property damage liability and $1,000,000 products/completed operations
aggregate; (b) Business Auto Liability covering owned, non-owned and hired
vehicles with a limit of not less than $1,000,000 per accident; (c) insurance
protecting against liability under Worker's Compensation Laws with limits at
least as required by statute; (d) Employers Liability with limits of $1,000,000
each accident, $1,000,000 disease policy limit, $1,000,000 disease--each
employee; (e) All Risk or Special Form coverage protecting Tenant against loss
of or damage to tenant's alterations, additions, improvements, carpeting, floor
coverings, panelings, decorations, fixtures, inventory and other business
personal property situated in or about the Premises to the full replacement
value of the property so insured, (f) Business Interruption Insurance for 100%
of the 12 month actual loss sustained, and, (d) Excess Liability in the amount
of $5,000,000.

     See Addendum.

     11.2 Each of the aforesaid policies shall (a) be provided at Tenant's
expense; (b) name the Landlord and the building management company, if any, as
additional insureds; (c) be issued by an insurance company with a minimum Best's
rating of "A:VII" during the Term; and (d) provide that said insurance shall not
be cancelled unless thirty (30) days prior written notice (ten days for
non-payment of premium) shall have been given to Landlord; and said policy or
policies or certificates thereof shall be delivered to Landlord by Tenant upon
the Commencement Date and at lease thirty (30) days prior to each renewal of
said insurance.

     11.3 Whenever Tenant shall undertake any alterations, additions or
improvements in, to or about the Premises ("Work") the aforesaid insurance
protection must extend to and include injuries to persons and damage to property
arising in connection with such Work, without limitation including liability
under any applicable structural work act, and such other insurance as Landlord
shall require; and the policies of or certificates evidencing such insurance
must be delivered to Landlord prior to the commencement of any such Work.

     See Addendum.

12. WAIVER OF SUBROGATION.

So long as their respective insurers so permit, Tenant and Landlord hereby
mutually waive their respective rights of recovery against each other for any
loss insured by fire, extended coverage, All Risks or other insurance now or
hereafter existing for the benefit of the respective party but only to the
extent of the net insurance proceeds payable under such policies. Each party
shall obtain any special endorsements required by their insurer to evidence
compliance with the aforementioned waiver.

13. SERVICES AND UTILITIES.

Tenant shall pay for all water, gas, heat, light, power, telephone, sewer,
sprinkler system charges and other utilities and services used on or from the
Premises, including without limitation, the cost of any central station
signaling system installed in the Premises together with any taxes, penalties
(unless due to Landlord's delay) and surcharges or the like pertaining thereto
and any maintenance charges for utilities. Any such charges paid by Landlord and
assessed against Tenant Shall be payable to Landlord within 30 days after
receipt of an invoice and shall be additional rent hereunder. Except as set
forth in Section 7.3 Landlord shall in no event be liable for any interruption
or failure of utility services on or to the Premises.

     See Addendum.

14. HOLDING OVER.

Tenant shall pay Landlord for each day tenant retains possession of the Premises
or part of them after termination of this Lease by lapse of time or otherwise at
the rate ("Holdover Rate") which shall be 150% of the amount of the Annual Rent
for the last period prior to the date of such termination plus all

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additional rent due under this Lease and If Tenant holds over without LandLord's
consent also pay all damages sustained by LandLord by reason of such retention.
If LandLord gives notice to Tenant of LandLord's election to that effect, such
holding over shall constitute renewal of this Lease for a period from month to
month at the Holdover Rate, but if the Landlord does not so elect, no such
renewal shall result notwithstanding acceptance by Landlord of any sums due
hereunder after such termination; and instead, a tenancy at sufferance at the
Holdover Rate shall be deemed to have been created. In any event, no provision
of this Article 14 shall be deemed to waive Landlord's right of reentry or any
other right under this Lease or at Law.

15. SUBORDINATION.

This Lease shall be subject and subordinate at all times to ground leases and to
the lien of any mortgages or deeds of trust now or hereafter placed on, against
or affecting the Building, Landlord's interest or estate in the Building, or any
ground or underlying lease; provided, however, that if the lessor, mortgage,
trustee, or holder of any such mortgage or deed of trust elects to have Tenant's
interest in this Lease be superior to any such instrument, then, by notice to
Tenant, this Lease shall be deemed superior, whether this Lease was executed
before or after said instrument. Notwithstanding the foregoing, Tenant covenants
and agrees to execute and deliver upon demand such further instruments
evidencing such subordination or superiority of this Lease as any be required by
Landlord.

     See Addendum

16. REENTRY BY LANDLORD.

     16.1 Landlord reserves and shall at all times have the right to re-enter
the Premises to inspect the same, to show said Premises to prospective
purchasers, mortgagees or tenants, to conduct environmental audits and/or
inspections and to alter, improve or repair the Premises and any portion of the
Building, without abatement of rent,* except as set forth in Section 7.3 and may
for that purpose erect, use and maintain scaffolding, pipes, conduits and other
necessary structures and open any wall, ceiling or floor in and through the
Building and Premises where reasonably required by the character of the work to
be performed, provided entrance to the Premises shall not be blocked thereby,
and further provided that the business of Tenant shall not be interfered with
unreasonably.

     See Addendum

     16.2 Tenant hereby waives any claim for damages for any injury or
inconvenience to or interference with Tenant's business, any loss of occupancy
or quiet enjoyment of the Premises, and any other loss occasioned by any action
of Landlord authorized by this Article 16. except to the extent caused by or
arising from the negligence or willful misconduct of Landlord or its agents,
employees or contractors. Tenant agrees to reimburse Landlord, on demand, as
additional rent, for any expenses which Landlord may incur in thus effecting
compliance with Tenant's obligations under this Lease.

     16.3

17. DEFAULT.

     17.1 Except as otherwise provided in Article 19, the following events shall
be deemed to be Events of Default under this Lease:

        17.1.1 Tenant shall fail to pay when due any sum of money becoming due
to be paid to Landlord under this Lease, whether such sum be any installment of
the rent reserved by this Lease, any other amount treated as additional rent
under this Lease, or any other payment or reimbursement to Landlord required by
this Lease, whether or not treated as additional rent under this Lease, and such
failure shall continue for a period of five days after written notice that such
payment was not made when due.

        17.1.2 Tenant shall fail to comply with any term, provision or covenant
of this Lease which is not provided for in another Section of this Article and
shall not cure such failure within 30 days (forthwith, if the failure involves a
hazardous condition caused by Tenant or its employees, agents, contractors or
invitees) after written notice of such failure to Tenant.

* except as set forth in section 7.3

                                       7
<Page>

        17.1.3 Tenant shall fail to vacate the Premises immediately upon
termination of this Lease, by lapse of time or otherwise, or upon termination of
Tenant's right to possession only.

        17.1.4 Tenant shall become insolvent, admit in writing its inability to
pay its debts generally as they become due, file a petition in bankruptcy or a
petition to take advantage of any insolvency statute, make an assignment for the
benefit of creditors, make a transfer in fraud of creditors, apply for or
consent to the appointment of a receiver of itself or of the whole or any
substantial part of its property, or file a petition or answer seeking
reorganization or arrangement under the federal bankruptcy laws, as now in
effect or hereafter amended, or any other applicable law or statute of the
United States or any state thereof.

        17.1.5 A court of competent jurisdiction shall enter an order, judgment
or decree adjudicating Tenant bankrupt, or appointing a receiver of Tenant, or
of the whole or any substantial part of its property, without the consent of
Tenant, or approving a petition filed against Tenant seeking reorganization or
arrangement or Tenant under the bankruptcy laws of the United States, as now in
effect or hereafter amended, or any state thereof, and such order, judgment or
decree shall not be vacated or set aside or stayed within thirty(30) days from
the date of entry thereof.

18.REMEDIES.

     18.1 Upon the occurrence of any of such events of default described in
Article 18.1 or elsewhere in this Lease, Landlord shall have the following
rights and remedies in addition to all other rights or remedies available to
Landlord in law or equity:

        18.1.1 The rights and remedies provided by California Civil Code Section
1951.2, including, but not limited to, the right to terminate Tenants's right to
possession of the Premises and to recover the worth at the time of award of the
amount by which the unpaid rent for the balance of the Term after the time of
award exceeds the amount of rental loss for the same period that the Tenant
proves could be reasonably avoided, as computed pursuant to subsection (b) of
said Section 1951.2;

        18.1.2 The rights and remedies provided by California Civil Code Section
1951.4, that allows Landlord to continue this Lease in effect and to enforce all
of its rights and remedies under this Lease, including the right to recover rent
as it becomes due, for so long as Landlord does not terminate Tenant's right to
possession; provided, however, if Landlord elects to exercise its remedies
described in this subsection and Landlord does not terminate this Lease, and if
Tenant requests Landlord's consent to an assignment of this Lease or a sublease
of the Premises at such time as Tenant is in default, Landlord shall not
unreasonably withhold its consent to such assignment or sublease. Acts of
maintenance or preservation, efforts to relet the Premises or the appointment of
a receiver upon Landlord's initiative to protect its interest under this Lease
shall not constitute a termination of Tenants's right to possession;

        18.1.3 The right to terminate this Lease by giving notice to Tenant in
accordance with applicable law;

        18.1.4 The right and power, as attorney-in-fact for Tenant, to enter the
Premises and remove therefrom all persons and property, to store such property
in a public warehouse or elsewhere at the cost of and for the account of Tenant,
and to sell such property and apply the proceeds therefrom pursuant to
applicable California law. Landlord, as attorney-in-fact for Tenant, may from
time to time sublet the Premises or any part thereof for such term or terms
(which may extend beyond the Term) and at such rent and such other terms as
Landlord in its sole discretion may deem advisable, with the right to make
alterations and repairs to the Premises. Upon each such subletting, (i) Tenant
shall be immediately liable for payment to Landlord of, in addition to
indebtedness other than rent due hereunder, the cost of such subletting and such
alterations and repairs incurred by Landlord and the amount, if any, by which
the rent for the period of such subletting (to the extent such period does not
exceed the Term) exceeds the amount to be paid as rent for the Premises for such
period, or (ii) at the option of Landlord, rents received from such subletting
shall be applied, first, to payment of any indebtedness other than rent due
hereunder from Tenant to Landlord; second, to the payment of any costs of such
subletting and of such alterations and repairs; third, to payment of rent due
and unpaid hereunder; and the residue, if any, shall be held by Landlord and
applied in payment of future rent as the same become due hereunder. If Tenant
has been credited with any rent to be received by such subletting under clause
(i) and such rent shall not be promptly paid to Landlord by the subtenant(s), or
if such rentals received from such subletting under clause (ii) during any month
are less than those to be paid during that month by Tenant hereunder, Tenant
shall pay any such deficiency to Landlord. Such deficiency shall be calculated
and paid monthly. For all purposes set forth in this subparagraph, Landlord is
hereby irrevocably appointed attorney-in-fact for Tenant, with power of
substitution. No taking of possession of the Premises by Landlord, as
attorney-in-fact for Tenant, shall be construed as an election on its part to
terminate this Lease unless a written notice of such intention is given to
Tenant. Notwithstanding any such subletting without termination, Landlord may at
any time thereafter elect to terminate this Lease for such previous breach; and

                                       8
<Page>

     18.1.5 The right to have a receiver appointed for Tenant upon application
by Landlord, to take possession of the Premises and to apply any rental
collected from the Premises and to exercise all other rights and remedies
available.

     18.1.6 For purpose of this Article 18: "worth at the time of award" shall
be computed by allowing interest at a per annum rate of ten percent and rent
with respect to each month shall be deemed to be a monthly rental arrived at by
adding (i) one twelfth of the Annual Rent, plus (iii) one twelfth of any items
of additional rent paid or payable by Tenant hereunder during the 12 consecutive
month period prior to the month in which Tenant's default occurs or one twelfth
of the annualized amount of the additional rent paid or payable and the last day
of the calender month prior to the month in which such default occurs, if such
default occurs during the first 12 calender months of the Term).

     18.2 See Addendum

     18.3 Pursuit of any of the foregoing remedies shall not preclude pursuit of
any of other remedies provided in this Lease or any other remedies provided by
law (all such remedies being cumulative), nor shall pursuit of any remedy
provided in this Lease constitute a forfeiture or waiver of any rent due to
Landlord under this Lease or of any damages accruing to Landlord by reason of
the violation of any of the terms, provisions and covenants contained in this
Lease.

     18.4 No act or thing done by Landlord or its agents during the Term shall
be deemed a termination of this Lease or an acceptance of the surrender of the
Premises, and no agreement to terminate this Lease or accept a surrender of said
Premises shall be valid, unless in writing signed by Landlord. No waiver by
Landlord of any violation or breach of any of the terms, provisions and
covenants contained in this Lease shall be deemed or construed to constitute a
waiver of any other violation or breach of any of the terms, provisions and
covenants contained in this Lease. Landlord's acceptance of the payment of
rental or other payments after the occurrence of an Event of Default shall not
be construed as a waiver of such Default, unless Landlord so notifies Tenant in
writing. Forbearance by Landlord in enforcing one or more of the remedies
provided in this Lease upon an Event of Default shall not be deemed or construed
to constitute a waiver of such Default or of Landlord's right to enforce any
such remedies with respect to such Default or any subsequent Default.

19. TENANTS BANKRUPTCY OR INSOLVENCY

        19.1.1

                                        9
<Page>

20. QUIET ENJOYMENT.

Landlord represents and warrants that it has full right and authority to enter
into this Lease and that Tenant, while paying the rental and performing its
other covenants and agreements contained in this Lease, shall peaceably and
quietly have, hold and enjoy the Premises for the Term without hindrance or
molestation from Landlord subject to the terms and provisions of this Lease.
Landlord shall not be liable for any interference or disturbance by other
tenants or third persons, nor shall Tenant be released from any of the
obligations of this Lease because of such interference or disturbance. See
Section 1.3 and Section 2.1.1.

21. DAMAGE BY FIRE, ETC.

     21.1 Landlord shall maintain all insurance policies deemed by Landlord to
be reasonably necessary or desirable and relating in any manner to protection,
preservation or operation of the Premises, including by not limited to standard
fire and extended coverage insurance covering the Premises in an amount not less
than ninety percent (90%) of the replacement cost thereof insuring against the
perils of fire and lightning and including extended coverage or, at Landlord's
option, all risk coverage and, if Landlord so elects, earthquake, flood and wind
coverages and Tenant Shall pay, as additional rent, the cost of such policies
upon demand by Landlord. Such insurance shall be for the sole benefit of
Landlord and under its sole control. Tenant shall not take out separate
insurance concurrent in form or contributing in the event of loss with that
required to be maintained by Landlord hereunder unless Landlord is included as a
loss payee thereon. Tenant shall immediately notify Landlord whenever any such
separate insurance is taken out and shall promptly deliver to Landlord the
policy or policies of such insurance.

     21.2 In the event the Premises or the Building are damaged by fire or other
cause and in Landlord's reasonable estimation such damage can be materially
restored within 365 days, Landlord shall forthwith repair the same and this
Lease shall remain in full force and effect, except that Tenant shall be
entitled to a proportionate abatement in rent from the date of such damage. Such
abatement of rent shall be made pro rata in accordance with the extent to which
the damage and the making of such repairs shall interfere with the use and
occupancy by Tenant of the Premises from time to time. Within forty-five (45)
days from the date of such damage, Landlord shall notify Tenant, in writing, of
Landlord's reasonable estimation of the length of time within which material
restoration can be made, and Landlord's determination shall be binding on
Tenant. For purposes of this Lease, the Building or Premises shall be deemed
"materially restored" if they are in substantially the same condition as existed
at the time of delivery of the Premises to Tenant.

     21.3 If such repairs cannot, in Landlord's reasonable estimation, be made
within 365 days, Landlord and Tenant shall each have the option of giving the
other, at any time within sixty (60) days after such damage, notice terminating
this Lease as of the date of such damage. In the event of the giving of such
notice, this Lease shall expire and all interest of the Tenant in the Premises
shall terminate as of the date of such damage as if such date had been
originally fixed in this Lease for the expiration of the Term. In the event that
neither Landlord nor Tenant exercises its option to terminate this Lease, then
Landlord shall repair or restore such damage, this Lease

                                       10
<Page>

continuing in full force and effect, and the rent he

     See Addendum.

     21.4 Landlord shall not be required to repair or replace any damage or loss
by or from fire or other cause to any panelings, decorations, partitions,
additions, railings, ceilings, floor coverings, office fixtures or any other
property or improvements installed on the Premises by or belonging to Tenant.
Any insurance which may be carried by Landlord or Tenant against loss or damage
to the Building or Premises shall be for the sole benefit of the party carrying
such insurance and under its sole control.

     21.5 In the event that Landlord should fail to complete such repairs and
material restoration within sixty (60) days after the date estimated by Landlord
therefor as extended by this Section 21.5, Tenant may at its option and as its
sole remedy terminate this Lease by delivering written notice to Landlord,
within fifteen (15) days after the expiration of said period of time, whereupon
the Lease shall end on the date of such notice or such later date the fixed in
such notice as if the date of such notice was the date originally fixed in this
Lease for the expiration of the Term; provided, however, that if construction is
delayed because of changes, deletions or additions in construction requested by
Tenant, strikes, lockouts, casualties, Acts of God war, material or labor
shortages, government regulation or control or other causes beyond the
reasonable control of Landlord, the period for restoration, repair or rebuilding
shall be extended for the amount of time Landlord is so delayed.

     21.6 See Addendum.

     21.7 In the event of any damage or destruction to the Building or Premises
by any peril covered by the provisions of this Article 21, it shall be Tenant's
responsibility to properly secure the Premises and upon notice from Landlord to
remove forthwith, at its sole cost and expense, such portion of all of the
property belonging to Tenant or its licensees from such portion or all of the
Building or Premises as Landlord shall request.

     21.8 The provisions of this Lease, including this Article, constitute an
express agreement between Landlord and Tenant with respect to any and all damage
to, or destruction of, all or part of the Premises or the Building and any
statute or regulation of the State of California, including, without
limitation, Section 1932(2) and 1934(4) of the California Civil Code, with
respect to any rights or obligations concerning damage or destruction in the
absence of an express agreement between the parties, and any other statute or
regulation, now or hereafter in effect, shall have no application to the Lease
or any damage or destruction to all or any part to the Premises or the Building.

22. EMINENT DOMAIN.

If all or any substantial part of the Premises shall be taken or appropriated by
any public or quasi-public authority under the power of eminent domain, or
conveyance in lieu of such appropriation, either party to this Lease shall have
the right, at its option, of giving the other, at any time within thirty (30)
days after such taking, notice terminating this Lease, except that Tenant may
only terminate this Lease by reason of taking or appropriation, if such taking
or appropriation shall be so substantial as to materially interfere with
Tenant's use and occupancy of the Premises. If neither party to this Lease shall
so elect to terminate this Lease, the rental thereafter to be paid shall be
adjusted on a fair and equitable basis under the circumstances. Landlord shall
be entitled to any and all income, rent, award, or any interest whatsoever in or
upon any such sum, which may be paid or made in connection with any such public
or quasi-public use or purpose, and Tenant hereby assigns to Landlord any
interest if may have in or claim to all or any part of such sums, other than any
separate award which may be made with respect to Tenant's trade fixtures and the
value of improvements installed and paid for by Tenant and moving relocation and
business interruption losses & expenses; Tenant shall make no claim for the
value of any unexpired Term.

23. SALE BY LANDLORD.

In event of a sale or conveyance by Landlord of the Building, the same shall
operate to release Landlord from any liability accruing thereafter upon any of
the covenants or conditions, expressed or implied, contained in this Lease in
favor of

                                       11
<Page>

Tenant, and in such event Tenant agrees to look solely to responsibility of the
successor in interest of Landlord in and to this Lease. Except as set forth in
this Article 23, this Lease shall not be affected by any such sale and Tenant
agrees to attorn to the purchaser of assignee, provided that Tenant's right to
possession continues unabated and Tenant's other rights under this Lease
continue undiminished, subject to the terms and conditions of this Lease. If any
security has been given by Tenant to secure the faithful performance of any of
the covenants of this Lease, Landlord may transfer of deliver said security,
as such, to Landlord's successor in interest and thereupon Landlord shall be
discharged from any further liability with regard to said security.

24. ESTOPPEL CERTIFICATES.

Within ten (10) days following any written request which Landlord may make from
time to time, Tenant shall execute and deliver to Landlord or mortgagee or
prospective mortgagee a sworn statement certifying: (a) the date of commencement
of this Lease; (b) the fact that this Lease is unmodified and in full force and
effect (or, if there have been modifications to this Lease, that this Lease is
in full force and effect, as modified, and stating the date and nature of such
modifications); (c) the date to which the rent and other sums payable under this
Lease have been paid; (d) the fact that there are no current defaults under this
Lease by either Landlord or Tenant except as specified in Tenant's statement;
and (e) such other matters as may be reasonably request by Landlord. Landlord
and Tenant intend that any statement delivered pursuant to this Article 24 may
be relied upon by any mortgagee, beneficiary or purchaser and Tenant shall be
liable for all loss, cost or expense resulting from the failure of any sale or
funding of any loan caused by any material misstatement contained in such
estoppel certificate. Tenant irrevocably agrees that is Tenant fails to execute
and deliver such certificate within such ten (10) day period Landlord or
Landlord's beneficiary or agent may execute and deliver such certificate on
Tenant's behalf, and such certificate shall be fully binding on Tenant.

     See Addendum

25. SURRENDER OF PREMISES.

     See Addendum

     25.1 In the event of Tenant's failure to arrange such joint inspection to
be held prior to vacating the Premises, Landlord's inspection at or after
Tenant's vacating the Premises shall be conclusively deemed correct for purposes
of determining Tenant's responsibility for repairs and restoration.

     25.2 At the end of the Term or any renewal of the Term or any renewal of
the Term of other sooner termination of this Lease, Tenant will peaceably
deliver up to Landlord Possession of the Premises, together with all
improvements or additions upon or belonging to the same, by whomsoever made, in
the same conditions first installed, broom clean and free of all debris,
excepting only condemnation or Landlord's failure to make repairs required by it
to make, ordinary wear and tear and damage by fire or other casualty. Tenant
may, and at Landlord's request shall, at tenant's sole cost, remove upon
termination of this Lease, any and all furniture, furnishings, movable
partitions of less than full height from floor to ceiling, trade fixtures and
other property installed by Tenant, title to which shall not be in or pass
automatically to Landlord upon such termination, repairing all damage caused by
such removal. Property not so removed shall, unless requested to the removed, be
deemed abandoned by the Tenant and title to the same shall thereupon pass to
Landlord under this Lease under this Lease as by a bill of sale. All other
alterations, additions and improvements in, on or to the Premises shall be dealt
with and disposed of as provided in Article 6. See Section 6.4

     25.3 All obligations of Tenant under this Lease not fully performed as of
the expiration or earlier termination of the Term shall survive the expiration
or earlier termination of the Term. In the event that Tenant's failure to
perform prevents Landlord from releasing the Premises, Tenant shall continue to
pay rent pursuant to the provisions of Article 14 until such performance is
complete.

     See Addendum

26. NOTICES.

Any notice or document required or permitted to be delivered under this Lease
shall be addressed to the intended recipient, shall be transmitted personally,
by fully prepaid registered or certified United States Mail return receipt
request, or by reputable independent contract delivery service furnishing a
written record of attempted or actual delivery, and shall be deemed to be
delivered when tendered for delivery to the addressee at its address set forth
on the Reference Page, or at such other address as it has then last specified by
written notice delivered in accordance with this Article 26, or if to Tenant at
either its aforesaid address of its last known registered office or home of a
general partner or individual owner, whether or not actually accepted or
received by the addressee.

                                       12
<Page>

27. TAXES PAYABLE BY TENANT.

28.  DEFINED TERMS AND HEADINGS.

The Article headings shown in this Lease are for convenience of reference and
shall in no way define, increase, limit or describe the scope or intent of any
provision of this Lease. Any indemnification or insurance of Landlord shall
apply to and inure to the benefit of all the following "Landlord Entities",
being Landlord, Landlord's investment manager, and the trustees, board of
directors, officers, general partners, beneficiaries, stockholders, employees
and agents of each of them. Any option granted to Landlord shall also include or
to be exercisable by Landlord's trustee, beneficiary, agents and employees, as
the case may be, provided such individual is designated in writing by Landlord.
In any case where this Lease is signed by more than one person, the obligations
under this Lease shall be joint and several. The terms "Tenant" and "Landlord"
or any pronoun used in place thereof shall indicate and include the masculine or
feminine, the singular or plural number, individuals, firms or corporations, and
each of their respective successors, executors, administrators and permitted
assigns, according to the context hereof. The term "rentable area" shall mean
the rentable area of the Premises or the Building as calculated by the Landlord
on the basis of the plans and specifications of the Building including a
proportionate share of any common areas. Tenant hereby accepts and agrees to be
bound by the figures for the rentable square footage of the Premises shown on
the Reference Page.

     See Addendum

29. TENANTS AUTHORITY.

If Tenant signs as a corporation each of the persons executing this Lease on
behalf of Tenant represents and warrants that Tenant has been and is qualified
to do business in the state in which the Building is located, that the
corporation has full right and authority to enter into this Lease, and that
all persons signing on behalf of the corporation were authorized to do so by
appropriate corporate actions. If Tenant signs as a partnership, trust or other
legal entity, each of the persons executing this Lease on behalf of Tenant
represents and warrants that Tenant has compiled with all applicable laws, rules
and governmental regulations relative to its right to do business in the state
and that such entity on behalf of the Tenant was authorized to do so by any and
all appropriate partnership, trust or other actions. Tenant agrees to furnish
promptly upon request a corporate resolution, proof of due authorization by
partners, or other appropriate documentation evidencing the due authorization of
Tenant to enter into this Lease.

     See Addendum

30. COMMISSIONS.

Each of the parties represents and warrants to the other that it has not dealt
with any broker or finder in connection with this Lease, except as described on
the Reference Page. Landlord shall pay the Real Estate Brokers described on the
Reference Page a commission pursuant to separate agreement.

                                       13
<Page>

31. TIME AND APPLICABLE LAW.

Time is of the essence of this Lease and all of its provisions. This Lease shall
in all respects be governed by the laws of the state in which the Building is
located, without reference to the choice of law and conflicts of laws rules and
principles of such state.

32. SUCCESSORS AND ASSIGNS

Subject to the provisions of Article 9, the terms, covenants and conditions
contained in this Lease shall be binding upon and inure to the benefit of the
heirs, successors, executors, administrators and assigns of the parties to this
Lease.

33. ENTIRE AGREEMENT.

This Lease, together with its exhibits, contains all agreements of the parties
to this Lease and supersedes any previous negotiations. There have been no
representations made by the Landlord or understandings made between the parties
other than those set forth in this Lease and its exhibits. This Lease may not be
modified except by a written instrument duly executed by the parties to this
Lease.

34. EXAMINATION NOT OPTION.

Submission of this Lease shall not be deemed to be a reservation of the
Premises. Landlord shall not be bound by this Lease until it has received a copy
of this Lease duly executed by Tenant and had delivered to Tenant a copy of this
Lease duly executed by Landlord, and until such delivery Landlord reserves the
right to exhibit and lease the Premises to other prospective tenants.
Notwithstanding anything contained in this Lease to the contrary, Landlord may
withhold delivery of possession of the Premises from Tenant until such time as
Tenant has paid to Landlord, the first month's rent as set forth in Article 3
and any sum owed pursuant to this Lease.

35. RECORDATION.

Tenant shall not record or register this Lease or a short form memorandum hereof
without the prior written consent of Landlord, and then shall pay all charges
and taxes incident such recording or registration.

36. LIMITATION OF LANDLORD'S LIABILITY.

Redress for any claim against Landlord under this Lease shall be limited to and
enforceable only against and to the extent of Landlord's interest in the
Building. The obligations of Landlord under this Lease are not intended to and
shall not be personally binding on, nor shall any resort be had to the private
properties of, any of its trustees or board of directors and officers, as the
case may be, its investment manager, the general partners thereof, or any
beneficiaries, stockholders, employees, or agents of Landlord or the investment
manager.

     See Addendum

LANDLORD:                                TENANT:

 CalWest Industrial Properties, LLC,      Invitrogen Corporation,
---------------------------------------  -----------------------------------
 a California limited liability company   a Delaware corporation

 BY: RREEF America, L.L.C., a
---------------------------------------  -----------------------------------
 Delaware limited liability company

By: /s/ [ILLEGIBLE]                      By: /s/ [ILLEGIBLE]
   ------------------------------------     --------------------------------

Title: VP - authorized Representative    Title: Vice President
      ---------------------------------        -----------------------------

Dated: 6/11, 2001                      Dated: June 6, 2001
      ------   ---                           --------   ---

                                         By: /s/ [ILLEGIBLE]
                                            --------------------------------

                                         Title: Vice President, Gen. Counsel
                                               -----------------------------
                                                          & Secretary
                                               -----------------------------

                                       14
<Page>

                                   EXHIBIT A

                attached to and made a part of Lease bearing the
                  Lease Reference Date of MAY 31, 2001 between
              CALWEST INDUSTRIAL PROPERTIES, LLC, as Landlord and
                       INVITROGEN CORPORATION, as Tenant

                                    PREMISES

Exhibit A is intended only to show the general layout of the Premises as of the
beginning of the Term of this Lease. It does not in any way supersede any of
Landlord's rights set forth in Section 16.1 with respect to arrangements and/or
locations of public parts of the Building and changes in such arrangements
and/or locations. It is not to be scaled; any measurements or distances shown
should be taken as approximate.

<Page>

                                   EXHIBIT A

[GRAPHIC]
<Page>

                                   EXHIBIT "B"

                          INITIAL ALTERATIONS BY TENANT

     Tenant shall construct its tenant improvements to the Premises, in
accordance with this EXHIBIT B, together with applicable provisions of the
Lease.

     1. TENANT'S PLAN APPROVAL. Tenant shall cause detailed plans and
specifications (the "PLANS") to be prepared and delivered to Landlord. The Plans
shall reflect the work to be performed within the Premises by Tenant to suitably
prepare the Premises for Tenant's use (the "TENANT'S WORK"). Landlord shall,
within seven (7) days (which shall be deemed a reasonable amount of time)
following its receipt of the Plans, either approve such Plans or provide Tenant
with the reasons that Landlord is withholding such approval. Landlord shall not
unreasonably withhold or delay its approval. If Landlord does not approve the
Plans, Tenant shall cause the Plans to be revised, consistent with Landlord's
comments, and then resubmit the Plans to Landlord for review. On such subsequent
review, Landlord's review shall be limited to those aspects of the Plans revised
or added in response to Landlord's prior review. Tenant shall undertake no work
until Landlord has finally approved the Plans.

     If the parties do not agree on the Plans within thirty (30) days after the
Plans are submitted to Landlord, the approval, conditional approval or
disapproval of the Plans shall be determined in the following manner: Landlord
and Tenant shall each appoint one (1) arbitrator who shall by profession be a
qualified licensed architect specializing in industrial buildings in Southern
California who shall have been active in such profession over the ten (10) year
period ending on the expiration of such thirty (30) day period. Each arbitrator
shall be appointed within fifteen (15) days after the expiration of such thirty
(30) day period. If within thirty (30) days after the arbitrators are appointed,
the arbitrators are unable to agree upon whether the Plans should be approved,
then the two (2) arbitrators so appointed shall, within fifteen (15) days after
expiration of said thirty (30) day period, agree upon and appoint a third
arbitrator who shall be qualified under the same criteria set forth hereinabove
for qualification of the initial two (2) arbitrators and who shall render a
decision, within fifteen (15) days following his or her appointment, regarding
whether the Plans should be approved, conditionally approved or disapproved. The
decision of the third arbitrator shall be binding upon Landlord and Tenant. If
the two (2) arbitrators fail to agree upon and appoint a third arbitrator, the
matter shall be decided forthwith by the American Arbitration Association
pursuant to its Commercial Arbitration Rules. The cost of the arbitration shall
be paid equally by Landlord and Tenant. The arbitrators shall consider only the
following factors in determining whether or not to approve the Plans: whether
the alterations, additions or improvements contemplated by the Plans will: (w)
adversely affect or adversely impact the structural integrity of the Building,
including but not limited to the roof of the Building, (x) void or limit the
roof warranty currently existing for the Building, (y) adversely affect or
adversely impact the watertightness of the Building, including but not limited
to the roof of the Building or (z) violate the CC&Rs or any governmental laws,
ordinances or regulations. Notwithstanding the foregoing, the arbitrators shall
nonetheless approve the Plans if the arbitrators determine that Tenant has
adequately addressed in the Plans all of the criteria set forth in (w), (x), (y)
and (z) above.

     It is contemplated that Tenant will make alterations, additions and
improvements to the Premises in order to address environment and safety aspects
and requirements in connection with Tenant's use of the Premises, including,
without limitation, laboratory exhaust hoods and other exhaust ventilation and
equipment requiring roof penetration, alterations to the Premises and facilities
within the Premises to address fire code compliance, life safety concerns,
product process containment and such other alterations to the Premises as are
required by applicable codes and regulations and/or deemed necessary or
appropriate in the judgment of professionals employed or retained by Tenant for
the purpose of determining appropriate facility design for employee safety and
compliance with applicable laws and regulations. Tenant shall have the right to
make such alterations, either as part of Tenant's Work or as an alteration,
addition or improvement pursuant to Section 6.1, and Landlord shall not
disapprove such alteration, addition or improvement, provided such alterations
comply with, or Tenant has adequately addressed, the

<Page>

criteria set forth in clauses (w), (x), (y) and (z) above.

     2.  CONSTRUCTION OF TENANT IMPROVEMENTS BY TENANT'S CONTRACTOR.
Performance of the Tenant's Work shall strictly conform to the approved Plans
and any deviation will require Landlord's prior approval, except for minor
deviations that do not affect any structural components of the Building.
Following Landlord's approval of the Plans, Tenant shall cause Tenant's Work to
be completed in accordance with sound construction practices and in a manner
consistent with this EXHIBIT B. After the Plans for the Tenant's Work have been
approved by Landlord, Tenant, and the local governing agencies, Tenant shall
submit to Landlord the name, address, license number, evidence of insurance and
any other information required by Landlord of Tenant's proposed contractor(s)
("CONTRACTOR") for Landlord's review and approval. Landlord shall not
unreasonably withhold its consent. If Landlord deems, in Landlord's reasonable
discretion, that Tenant's proposed Contractor is unacceptable, Tenant shall
resubmit information on a replacement contractor until a mutually approved
Contractor is selected. Upon said selection, Tenant shall enter into a
construction contract with the Contractor which shall include a provision for
compliance with provisions of this EXHIBIT B of this lease applicable to the
construction of Tenant's Work. Violations of this EXHIBIT B of the Lease shall
constitute a default of this Lease if not corrected by Tenant and/or Tenant's
Contractor within three (3) days after notice, either written or oral, by
Landlord to Tenant; provided, however, if the nature of such violation is such
that more than three (3) days are reasonably required for its performance, then
Tenant shall not be in breach if performance is commenced within such three (3)
day period and thereafter diligently pursued to completion. Landlord shall have
the right to post notices of non-responsibility at prominent locations at the
Premises.

         It shall be the responsibility of Tenant to enforce the following
requirements of Tenant's Contractor, and all subcontractors of Tenant's
Contractor, at every level:

         2.1 Tenant's Contractor shall be responsible for the repair,
replacement and clean up of any damage by Contractor to the Building and the
Premises, including but not limited to access ways to the Premises, which may be
concurrently used by others.

         2.2 All work shall be done in accordance with sound construction
practices and, as required, in compliance with specifications of a soils
engineer or consultant as approved by Landlord.

         2.3 All trash, debris and surplus construction materials shall be
promptly removed from the Premises. All excess soil shall be removed from the
Premises within a reasonable amount of time, but, in any event, no later than
the completion of Tenant's Work.

         2.4 Tenant's Contractor shall provide temporary utilities, portable
toilet facilities and potable drinking water as required for the completion of
Tenant's Work.

         2.5 Noise shall be kept to a reasonable level at all times.

         2.6 Tenant and Tenant's Contractor are responsible for compliance with
all applicable codes and regulations of duly constituted authorities having
jurisdiction as far as the performance of the Tenant's Work is concerned and for
all applicable safety regulations established by the Landlord, OSHA or other
regulatory agencies. Prior to commencement of construction, Tenant shall submit
to Landlord evidence of insurance for Tenant's Contractor satisfactory to
Landlord.

         2.7 Tenant shall be responsible for and shall obtain and record a
Notice of Completion promptly following completion of Tenant's Work.

         2.8 Tenant shall provide to Landlord a copy of the fully executed
construction contract, including all addenda and a line item breakdown by trade
thereto, between Tenant and its Contractor for the Tenant's Work (the
"CONSTRUCTION CONTRACT").

         2.9 All required permits and approvals, including but not limited to
Planning,

                                        2
<Page>

Building, Fire, and Health department permits, must be obtained and all
necessary calculations, including, but not limited to, those required under
Title 24, must be submitted to the local governing agencies for all work to be
performed by Tenant or Tenant's Contractor in the Premises. Notwithstanding the
foregoing, Landlord shall deliver the Premises in compliance with Title 24.

         2.10 Any modifications to the Building exterior shall be subject to
Landlord's prior approval. No romex wiring shall be allowed, nor shall water
lines be placed in slabs. All equipment placed upon the roof as a result of the
Tenant's Work, and all roof penetrations, shall be approved by Landlord prior to
the commencement of work.

         2.11 Landlord, at Landlord's reasonable discretion, may from time to
time establish such other rules and regulations for protection of property and
the general safety of occupants and invitees of the Premises. Such rules and
regulations shall apply to Tenant and Tenant's Contractor as though established
upon the execution of this EXHIBIT B. Notwithstanding the foregoing, such rules
and regulations shall not conflict with the terms of this Lease.

         2.13 Tenant shall provide to Landlord: (i) a complete set of "as
built" plans and specifications and (ii) copies of all construction warranties
and guarantees in connection with the construction of the Tenant's Work to the
extent obtained. Upon any termination of this Lease, Tenant will assign all
construction warranties and guarantees to Landlord.

     3.  NO LANDLORD LIABILITY. Landlord shall not be liable for any loss,
cost, damage or expense incurred or claimed by Tenant or any other person or
party on account of the construction or installation of the Tenant's Work or any
other person or party on account of the construction or installation of the
Tenant's Work or any other improvements to the Premises made by Tenant, except
to the extent of Landlord's negligence or willful misconduct. Tenant hereby
acknowledges and agrees that the compliance of the Tenant's Work, or other
alterations made to the Premises by Tenant and any plans therefore, with all
applicable governmental laws, codes and regulations shall be solely Tenant's
responsibility. Landlord assumes no liability or responsibility resulting from
the failure of the Tenant to comply with all applicable governmental laws, codes
and regulations or for any defect in any of the Tenant's Work or other
alteration to the Premises made by Tenant. Tenant further agrees to indemnify,
defend and hold harmless Landlord from any loss, cost, damage or expense
incurred, claimed, asserted or arising in connection with any of Tenant's Work,
except to the extent of Landlord's negligence or willful misconduct.

                                        3
<Page>

     Premises. Without limiting the generality of the foregoing, the
     indemnifications shall also specifically cover costs in connection with
     Hazardous Materials that migrate, flow, percolate, diffuse or in any way
     move onto, under or off of the Premises after date of this Lease.

         If, during the Term of this Lease, Tenant discovers any Hazardous
     Materials at the Premises which are not the result of acts or omissions of
     Tenant or its employees, agents, contractors or invitees, Landlord shall
     remediate such Hazardous Materials to a level as required by governmental
     authorities.

         Tenant shall not be required to comply with any Environmental Laws as
     a result of a violation thereof by anyone other than Tenant, its agents,
     contractors, invitees or employees. In connection with Tenant's permitted
     use of the Premises, Tenant may use biological materials and Hazardous
     Materials including but not limited to the following materials: Acrylamide,
     Bis-Acrylamide, Chloroform, Dichloromethane, Formaldehyde, Hexamine Cobalt
     III, Lead Solder, Nickel(II) Chloride Hexahydrate, Penicillin/Streptomycin
     Sulfate, Potassium Bromate, Trichloroacetic Acid/Dichloromethane and Trypan
     Blue (Landlord acknowledges that the foregoing is not an all inclusive
     list), provided Tenant always handles, stores, uses and disposes of such
     biological materials and Hazardous Materials in compliance with all
     applicable Laws and Environmental Laws and never allows such biological
     materials or Hazardous Materials to contaminate the Premises, the Building
     and appurtenant land or allow the environment to become contaminated with
     any biological materials or Hazardous Materials. The parties acknowledge
     that biological materials may in some cases constitute a Hazardous Material
     as defined in this Lease, and in such case, provisions of this Lease
     relating to Hazardous Materials apply to any and all such Hazardous
     Materials, including but not limited to biological materials, whether or
     not such provision makes specific mention to biological materials.

         Tenant shall provide Landlord with copies of any Hazardous Material
     Inventories (as required by the San Diego County Department of
     Environmental Health, Hazardous Materials Division) relating to any
     Hazardous Materials to be used, kept or stored at or on the Premises. In
     the event that San Diego County no longer requires Hazardous Material
     Inventories, Tenant agrees to continue to provided such an inventory to
     Landlord in the same format and on the same conditions as provided
     previously. Tenant shall promptly send to Landlord a copy of any notices
     delivered to any government entities in connection with any release of
     Hazardous Materials relating to or concerning the Premises. Information
     contained on such Hazardous Materials Inventories shall be considered
     confidential information, and in regards thereto, Landlord agrees to comply
     with the terms of the Confidentiality Agreement attached hereto as Exhibit
     "D-2" and by this reference incorporated herein.

         Any increase in the premiums for necessary insurance on the Premises
     which arises from Tenant's use and/or storage of Hazardous Materials shall
     be solely at Tenant's expense."

     3.  COVENANTS, CONDITIONS AND RESTRICTIONS: ROOF LEASE. Section 1.3 is
hereby added to the Lease and shall read as follows:

         "Tenant accepts the Premises subject to: (i) the Third Amended and
Restated Declaration of Covenants, Conditions and Restrictions of Carlsbad
Research Center dated March 10, 1988 and recorded June 29, 1988 as Instrument
No. 88-313420 with the San Diego County Recorder as the same may be amended from
time to time (the 'CC&RS') and (ii) the existing Roof Lease dated as of
September 25, 2000 (the 'ROOF LEASE') with Edison Development Corporation
('EDISON'). Landlord shall not enter in any future roof leases concerning the
Premises. Pursuant to the Roof Lease, Edison has installed a solar photovoltaic
system (the 'SYSTEM') on the roof of the Building. RealEnergy, Inc.
('REALENERGY') leases the System from Edison and operates the System. Tenant

                                        2
<Page>

     agrees to use commercially reasonable efforts to place its roof equipment
     in locations that will not interfere with the System and will not cast
     shadows upon the System. Landlord agrees to use reasonable efforts to
     obtain the written agreement from Edison and RealEneregy that Tenant may go
     onto the Roof of the Building without prior notification to, or consent
     from, either Edison or RealEnergy; provided, however, Tenant agrees to
     notify RealEnergy prior to going onto the portion of the Roof occupied by
     Edison for the System. Notwithstanding anything contained herein, if
     Landlord fails to obtain such written agreement (and provide a copy to
     Tenant) by June 30, 2001, Tenant shall have the right to terminate this
     Lease by notifying Landlord on or before July 15, 2001, and, in such event,
     both parties shall be relieved of any further liability hereunder. Any time
     after the first three (3) years of the term of the Roof Lease, Landlord
     agrees within five (5) days after notice from Tenant to notify Edison that
     Landlord is terminating the Roof Lease pursuant to Section 16.3 thereof,
     and Landlord agrees to pay any termination fee in connection therewith."

     4.   EARLY OCCUPANCY; RENT. The following sentences are hereby added to the
end of Section 2.1.1:

          "Except for the Roof Lease, Landlord shall deliver the Premises to
      Tenant free of all tenancies; provided, however, Tenant acknowledges that
      a month to month tenant ('TAYLOR MADE') currently occupies a portion of
      the Premises at the north end of the Building. Notwithstanding anything
      contained herein, if Landlord fails to provide early occupancy of the
      Taylor Made portion of the Premises to Tenant within ninety (90) days
      after Tenant has executed and delivered this Lease to Landlord along with
      the first month's rent (the 'EARLY OCCUPANCY DATE'), then, for every day
      after the Early Occupancy Date that Landlord so delays, Tenant shall be
      entitled to one (1) day of free rent. Notwithstanding anything contained
      herein, if Landlord fails to provide occupancy of the Premises to Tenant
      by November 1, 2001, Tenant shall have the right to terminate this Lease
      by notifying Landlord on or before November 15, 2001, and, in such event,
      both parties shall be relieved of any further liability hereunder. Except
      for the portion of the Premises currently occupied by Taylor Made, Tenant
      shall be granted early occupancy of the Premises as of the mutual
      execution of this Lease and delivery by Tenant of the first month's rent
      for the purpose of constructing its tenant improvements. Tenant shall be
      exclusively responsible for all utility costs during the construction of
      the tenant improvements; however, such early occupancy period shall be on
      a rent-free and expense-free basis. Until delivery of possession of the
      portion of the Premises occupied by Taylor Made, Tenant may have access to
      such portion of the Premises during normal business hours for purposes of
      making inspections and measurements, provided that Tenant gives Landlord
      at least twenty-four (24) hours notice and that Landlord accompanies
      Tenant. Landlord agrees, at its cost, to repair any damage to the Premises
      caused by Taylor Made."

     5.   OPTIONS TO EXTEND LEASE TERM. The following Section 2.3 is hereby
added to the Lease and shall read as follows:

          "2.3.1 EXTENDED TERM. Subject to the earlier termination of this Lease
     in accordance with the provisions of this Lease, Tenant shall have the
     options (the 'OPTIONS') to renew and extend the Term of the Lease for two
     (2) additional five (5) year periods (the 'EXTENDED TERM'). Any references
     in this Lease to 'Term' shall include the Extended Term, where applicable.
     Tenant shall notify Landlord of Tenant's intention to renew and extend by
     notice delivered to Landlord no later than one hundred eighty (180) days
     nor more than two hundred and seventy (270) days prior to the expiration of
     the then applicable Term of the Lease.

          2.3.2 ADJUSTMENT IN MONTHLY INSTALLMENT OF ANNUAL RENT. In the event
     this Lease is renewed and extended on the basis of the foregoing, the Lease
     shall continue to be governed by the terms and conditions hereof (except
     that there shall be no further options besides the Options described
     herein); provided,

                                        3
<Page>

     however, that the Monthly Installment of Annual Rent shall be adjusted to
     the then fair market rental value of the Premises as of the time of the
     expiration of the then applicable Term of the Lease, for rental space with
     a similar percentage of office space of the Premises and a similar number
     of parking spaces per 1,000 square feet of space in the Building, and not
     including any improvements made to portions of the Premises not usable for
     office purposes. Such fair market rental value shall be determined by
     agreement between the parties within thirty (30) days following delivery of
     Tenant's notice of renewal and extension. However, if the parties cannot
     reach such agreement within said thirty (30) day period, such fair market
     rental value shall be determined in the following manner: Landlord and
     Tenant shall each appoint one (1) arbitrator who shall by profession be a
     qualified licensed real estate broker who shall have been active over the
     five (5) year period ending on the date the applicable Option is exercised
     in the leasing of industrial and commercial real property in San Diego
     County. Each arbitrator shall be appointed within ten (10) days after the
     expiration of the thirty (30) day mutual agreement period described
     hereinabove. If within thirty (30) days after the arbitrators are
     appointed, the arbitrators are unable to agree upon the fair market value,
     then the two(2) arbitrators so appointed shall, within fifteen (15) days
     after expiration of said thirty (30) day period, agree upon and appoint a
     third arbitrator who shall be qualified under the same criteria set forth
     hereinabove for qualification of the initial two arbitrators and who shall
     render a decision regarding fair market rental value within fifteen (15)
     days following his or her appointment. The decision of the third arbitrator
     shall be binding upon Landlord and Tenant. If the two (2) arbitrators fail
     to agree upon and appoint a third arbitrator, the matter shall be decided
     forthwith by the American Arbitration Association pursuant to its
     Commercial Arbitration Rules. The cost of the arbitration shall be paid
     equally by Landlord and Tenant. The determination of fair market rental
     value by the arbitrators under this Section 2.3.2 shall include
     determinations for the increases to the Monthly Installment of Annual Rent
     each year during the Extended Term.

          2.3.3 LIMITATIONS. Tenant may not exercise either of the Options
     during any period of time when an Event of Default is continuing. The
     period of time within which an Option may be exercised shall not be
     extended or enlarged by reason of Tenant's inability to exercise an Option
     due to the occurrence of an Event of Default."

     6. RENT. The following sentences are hereby added to the end of Section
3.1:

        "The Monthly Installment of Annual Rent payable under the Lease shall
     commence November 1, 2001 and thereafter shall be calculated and
     increased as follows:

        Subject to the rent abatement described in Section 2.1.1 above,
        effective November 1, 2001 the Initial Monthly Installment of Annual
        Rent shall be $116,925.76;

        Subject to the rent abatement described in Section 2.1.1 above,
        effective May 1, 2002 the Monthly Installment of Annual Rent shall be
        $179,214.00; Commencing on November 1, 2002 the thereafter every
        November 1st during the Term of the Lease the Monthly Installment of
        Annual Rent shall be increased by three percent (3%).

        The Annual Rent shall be correspondingly adjusted to conform with the
     above described increases and/or abatement of Monthly Installment of Annual
     Rent."

     7. ADDITIONAL RENT. Section 3.3 is hereby added to the Lease and shall read
as follows:
                                       4
<Page>

        "All monetary obligations of Tenant under this Lease are deemed to be
     rent."

     8. TAXES. The following sentence is hereby added to the end of
Section 4.1:

        "The term 'Taxes' shall also include any tax, fee, levy, assessment or
     charge or any increase therein imposed by reason of events occurring during
     the Term of this Lease, including but not limited to a change in the
     ownership of the Premises; provided, however, the term 'Taxes' shall
     exclude any tax or assessment arising out of more than two (2) sales or
     changes in ownership of the Premises occurring during the first five (5)
     years of the Term (except insofar as such tax or assessment relates to
     Tenant's alterations or improvements to the Premises). The term 'Taxes'
     shall not include documentary transfer taxes assessed in connection with a
     sale or transfer by Landlord of the Premises."

     9. ALTERATIONS. The following sentence is hereby added to the end of
Section 6.1:

        "Landlord's consent shall not be required for Tenant to make
     nonstructural alterations, additions or improvements which do not impact,
     involve or affect the roof of the Building. Landlord shall not disapprove
     alterations, additions or improvements affecting the structural components
     or the Building or the roof of the Building unless Landlord reasonably
     determines that such alterations, additions or improvements will: (i)
     adversely affect or adversely impact the structural integrity of the
     Building, including but not limited to the roof of the Building, (ii) void
     or limit the roof warranty currently existing for the Building, (iii)
     adversely affect or adversely impact the watertightness of the Building,
     including but not limited to the roof of the Building or (iv) violate the
     CC&Rs or any governmental laws, ordinances or regulations. Notwithstanding
     the foregoing, Landlord shall approve any alterations, additions or
     improvements affecting the structural components of the Building or the
     roof of the Building if Landlord determines that Tenant has adequately
     addressed the matters set forth in (i), (ii), (iii) and (iv) above."

     10. ALTERATIONS: TENANT'S CONTRACTOR. The following sentences are hereby
added to the end of Section 6.2:

        "Tenant shall use licensed and bonded contractor, subject to Landlord's
     approval, which shall not be unreasonably withheld. Landlord shall have the
     right to post notices of non-responsibility at prominent locations at the
     Premises."

     11. REMOVAL OF ALTERATIONS: TENANT'S PROPERTY. Section 6.4 is hereby
restated to read as follows:

        "All alterations, additions and improvements in, on or to the Premises
     made or installed by Tenant, including carpeting, shall be and remain the
     property of Tenant during the Term but, except as set forth below, shall
     become a part of the realty and belong to Landlord without compensation to
     Tenant upon the expiration or sooner termination of the Term, at which time
     title shall pass to Landlord under this Lease as by a bill of sale, unless
     Landlord elects otherwise. Upon such election by Landlord, Tenant shall (on
     or before the termination of the Term) upon demand by Landlord, at Tenant's
     sole cost and expense, forthwith and with all due diligence remove any such
     alterations, additions or improvements which are designated by Landlord to
     be removed, provided that Landlord notified Tenant when it consented to
     such alterations, additions or improvements that Landlord may require their
     removal upon termination of this Lease, and provided further that during
     the first or second Option period of the Extended Term, the cost of such
     removal shall be split equally between the parties. Notwithstanding
     anything to the contrary above, Tenant shall not be required to remove such
     alterations, additions or improvements if this Lease is terminated by
     Landlord pursuant to Section 21.3 below. In connection with such removal,
     Tenant shall forthwith and with all due diligence, at its sole cost and
     expense, repair and

                                       5
<Page>

     restore the Premises to their original condition, ordinary wear and tear
     and damage by fire or other casualty, condemnation, acts of God, or
     Landlord's failure to make required repairs excepted.  Any trade fixtures,
     business equipment, inventory, signs, counters, movable partitions of less
     than full height from floor to ceiling, shelving, furniture and other
     removable personal property installed in or on the Premises by Tenant at
     its expense ('TENANT'S PROPERTY'), shall remain the property of Tenant.
     Landlord agrees that Tenant shall have the right, at any time or from time
     to time, to remove any and all of Tenant's Property, provided Tenant
     repairs any damage caused to the Premises from such removal".

     12.  LANDLORD'S MAINTENANCE OBLIGATIONS.  The first sentence of Section 7.1
is hereby deleted and replaced with the following sentences:

        "Subject to the provisions of Sections 21 (Damage) and 22 (Eminent
     Domain), and subject to reimbursement pursuant to Article 7, Landlord shall
     keep in good order, condition and repair the foundations, exterior walls,
     structural condition of interior bearing walls, exterior roof, fire
     sprinkler system, fire alarm and/or smoke detection systems, fire hydrants,
     parking lots, walkways, parkways, driveways, landscaping fences, signs and
     utility systems serving the Premises (including the main sewer line) and
     all parts thereof. Landlord shall not be obligated to paint the interior of
     the Building, including, but not limited to, the interior surfaces of
     exterior walls, not shall Landlord be obligated to maintain, repair or
     replace windows, doors or glass of the Premises. Tenant accepts the
     Premises in its current 'as is' condition, provided, Landlord shall ensure
     that all building systems, power, roof, existing heating and air
     conditioning systems, windows and seals, mechanical systems, and electrical
     and plumbing systems and equipment are in good condition as of the date
     Landlord delivers the Building to Tenant. Landlord makes no representation
     as to the suitability of the Premises for Tenant's intended use. In
     addition, Landlord shall deliver the Building in a condition that complies
     with all codes and regulations, including, but not limited to, the
     Americans With Disabilities Act and Title 24 requirements.

        To the best of Landlord's actual knowledge, Landlord represents and
     warrants that there are no latent defects in the Building. If Tenant
     notifies Landlord of a latent defect in the Building prior to two hundred
     and seventy (270) days after mutual execution and delivery of this Lease,
     Landlord shall correct and repair such defect at its sole cost and expense.
     If Tenant does not notify Landlord of a latent defect in the Building prior
     to such date, correction of any such defect shall be the obligation of the
     party otherwise responsible therefor pursuant to the terms of this Lease.

        Landlord shall not be liable for any failure to make any repairs or to
     perform any maintenance unless Landlord fails within a reasonable time to
     perform such obligation required to be performed by Landlord. For purposes
     of this Section, a reasonable time shall in no event be less than thirty
     (30) days after receipt by Landlord of written notice; provided, however,
     if the nature of Landlord's obligation is such that more than thirty (30)
     days are reasonably required for its performance, then Landlord shall not
     be in breach if performance is commenced within such thirty (30) day period
     and thereafter diligently pursued to completion. Performance shall be
     deemed to have commenced if: (i) repair work has actually commenced or (ii)
     Landlord is in the process of obtaining bids from contractors or having
     plans and specifications prepared in connection with such repair work. If
     Landlord breaches its obligation to make any repairs or to perform any
     maintenance required to be performed by Landlord, or in the event of an
     emergency roof leak that is not repaired by Landlord within three (3) days
     after notice to Landlord, Tenant may repair the same itself where the cost
     of such repairs does not require an expenditure of more than Fifty Thousand
     Dollars ($50,000) and deduct the expenses of such repairs from the rent
     when due.

                                       6<Page>

         Landlord shall only be obligated to paint the exterior of the Building
     as reasonably needed, but in no event more than once every five (5) years.

         Landlord shall also be responsible for repairing the interior ceiling
     of the Building at its sole cost if materially damaged by roof leaks,
     unless such leaks result from: (i) the actions or willful misconduct of
     Tenant or its employees, agents, contractors or invitees or (ii) equipment,
     machinery or other improvements installed on the roof of the Building by or
     for Tenant.

         In no event shall Tenant be required to make any structural repairs to
     the Building or be responsible for any direct or indirect costs arising
     from or relating to the Roof Lease (including but not limited to repair,
     maintenance or replacement of the roof) unless such repairs are necessary
     due to the negligence, willful misconduct or other actions or use of the
     Premises by Tenants or its employees, agents, contractors or invitees.
     Tenant shall be responsible for any increased or additional costs for
     replacement or repair of the roof of the Building arising out of or due to
     Tenant's roof penetrations or roof equipment.

         Regarding the roof of the Building, during the initial Term, any
     decision as to whether the roof needs to be replaced shall be made by
     Landlord in its sole and absolute discretion. During the Extended Term,
     Tenant shall notify Landlord if it feels that the roof of the Building
     needs to be replaced. If the parties cannot reach a mutual agreement within
     thirty (30) days after Landlord's receipt of such notice from Tenant
     concerning the roof, the decision of whether the roof should be replaced
     shall be determined in the following manner: Landlord and Tenant shall each
     appoint one (1) arbitrator who shall by profession be a qualified licensed
     consultant specializing in roofs and roofing systems in Southern California
     who shall have been active in such business over the ten (10) year period
     ending on the date of Tenant's notice to Landlord. Each arbitrator shall be
     appointed within ten (10) days after the expiration of the thirty (30) day
     mutual agreement period described hereinabove. If within thirty (30)days
     after the arbitrators are appointed, the arbitrators are unable to agree
     upon whether the roof should be replaced, then the two(2) arbitrators so
     appointed shall, within fifteen (15) days after expiration of said thirty
     (30) day period, agree upon and appoint a third arbitrator who shall be
     qualified under the same criteria set forth hereinabove for qualification
     of the initial two (2) arbitrators and who shall render a decision, within
     fifteen (15) days following his or her appointment, regarding whether the
     roof should be replaced. The decision of the third arbitrator shall be
     binding upon Landlord and Tenant. If the two (2) arbitrators fail to agree
     upon and appoint a third arbitrator, the matter shall be decided forthwith
     by the American Arbitration Association pursuant to its Commercial
     Arbitration Rules. The cost of the arbitration shall be paid equally by
     Landlord and Tenant."

     13. ABATEMENT. The following sentences are hereby added to the end of
Section 7.3 and shall read as follows:

         "In the event Tenant is prevented from using the Premises for five (5)
     consecutive days or seven (7) days in any twelve (12) month period: (i) as
     a result of any repair, maintenance, inspection, audit or alteration
     performed by Landlord which materially interferes with Tenant's use of the
     Premises or (ii) if due to Landlord's negligence or willful misconduct
     there is any interruption or termination of utilities or access to the
     Premises, then rent and all other charges payable by Tenant (except charges
     payable pursuant to Section 10 of this Lease) shall be abated or reduced,
     as the case may be, for such time exceeding the five (5) and seven (7) day
     time periods. Any reduction in rent shall be based upon the proportion of
     the rentable area of the Premises that Tenant is prevented from using bears
     to the total rentable area of the Premises. In the event that Tenant is
     prevented from conducting its business in any portion of the Premises, and
     the remaining portion of the Premises is not sufficient to allow Tenant to
     effectively conduct its business therein, then for such time exceeding the
     five (5) and seven (7) day time periods described above, the rent for the
     entire Premises and all other

                                       7
<Page>

     charges payable by Tenant (except charges payable pursuant to Section 10 of
     this Lease) shall be abated."

     14. PAYMENT OF OPERATING EXPENSES. Sections 7.6 through 7.12 are hereby
added to the Lease and shall read as follows:

         "7.6 Except for sums expended by Landlord for the payment of repairs,
     maintenance or capital improvements concerning the foundations, main sewer
     line, exterior walls and structural condition of interior bearing walls,
     all sums expended by Landlord for operation, maintenance, repair and
     management of the Premises including, but not limited to, roof repairs and
     maintenance; parking lot resurfacing; painting; re-striping; sewer
     maintenance; cleaning; window cleaning; supplies and material costs;
     licenses, permits and inspection fees; owners' association assessments;
     sweeping; replacement of exterior light bulbs; pest control;
     planting, replanting, replacing foliage, tree trimming and landscaping;
     lighting and other utilities; directional signs and other markers and
     bumpers; alarm services (including any central station signaling system);
     and $1,000 per month for Landlord's supervision of the Premises
     (collectively 'OPERATING EXPENSES') shall be payable by Tenant to Landlord.
     Landlord may cause any or all services to be provided by an independent
     contractor. No other management fee shall be payable by Tenant to Landlord.
     Landlord currently estimates that the Operating Expenses are five cents
     ($.05) per square foot per month, the Taxes are six cents ($.06) per square
     foot per month and insurance is one cent ($.01) per square foot per month.

         7.7  The annual determination of Operating Expenses shall be made by
     Landlord and shall be certified by a nationally recognized firm of public
     accountants selected by Landlord ('LANDLORD'S ACCOUNTANTS').

         7.8  Prior to the actual determination thereof for each calendar year
     falling partly or wholly within the Term (each a 'LEASE YEAR'), Landlord
     may from time to time estimate Tenant's liability for Operating Expenses
     for a Lease Year or portion thereof. Landlord will give Tenant written
     notification of the amount of such estimate and Tenant agrees that it will
     pay, by increase of its Monthly Installment of Rent due in such Lease Year,
     additional rent in the amount of such estimate. Any such increased rate of
     Monthly Installment of Rent pursuant to this Section 7.8 shall remain in
     effect until further written notification to Tenant pursuant hereto.

         7.9  When the above mentioned actual determination of Tenant's
     liability for Operating Expenses is made for any Lease Year and when Tenant
     is so notified in writing, then:

               7.9.1 If the total additional rent Tenant actually paid pursuant
         to Section 7.8 on account of Operating Expenses for the Lease Year is
         less than Tenant's liability for Operating Expenses, then Tenant shall
         pay such deficiency to Landlord as additional rent in one lump sum
         within thirty (30) days of receipt of Landlord's bill therefor;

              7.9.2 If the total additional rent Tenant actually paid pursuant
         to Section 7.8 on account of Operating Expenses for the Lease Year is
         more than Tenant's liability for Operating Expenses, then Landlord
         shall credit the difference against the then next due payments to be
         made by Tenant under this Article 7.

         7.10 If the Commencement Date is other than January 1 or if the
     Termination Date is other than December 31, Tenant's liability for
     Operating Expenses for the Lease Year in which such date occurs shall be
     prorated based upon a three hundred sixty-five (365) day year.

                                       8
<Page>

         7.11 Provided an Event of Default is not continuing, Tenant shall have
     the right to audit Landlord's books during normal business hours upon at
     least fifteen (15) days advance notice given within two hundred seventy
     (270) days after certification by Landlord's Accountant. In addition, in
     the event that such audit discloses an overstatement by Landlord of five
     percent (5%) or more for an accounting period, Landlord shall promptly pay
     the cost of such audit, provided Landlord agrees with the results of such
     audit or there is a final determination concerning the results of such
     audit, as set forth below. Should Landlord disagree with the results of
     Tenant's audit, then Landlord's Accountant and Tenant's accountant shall
     promptly mutually agree upon a nationally recognized firm of public
     accountants, who shall be engaged to review the information prepared by
     Landlord's Accountant, Tenants audit and such other information as such
     accounting firm may reasonably request. Such third accounting firm's
     determination of the Operating Expenses shall be conclusive upon Landlord
     and Tenant. Should Tenant fail to object in writing to Landlord's
     determination of operating Expenses within two hundred and seventy (270)
     days after certification by Landlord's Accountant, Landlord's determination
     of Operating Expenses for the applicable period shall be conclusive and
     binding on the parties. If either Landlord or Tenant is owed money based
     upon the final determination of Operating Expenses, such party shall be
     paid by the other party within thirty (30) days after the final
     determination of Operating Expenses.

         7.12 Notwithstanding any provision of this Lease to the contrary,
     Landlord and Tenant acknowledge and agree that the following items shall be
     excluded from Operating Expenses:

               7.12.1 Repairs or other work occasioned by fire, windstorm or
     other casualty covered by insurance or by the exercise of eminent domain or
     any expenditures for which Landlord is entitled to reimbursement from any
     source, including without limitation insurance and condemnation proceeds;

               7.12.2 All costs and expenses associated with leasing to other
     tenants, including tenant improvement allowances, attorney's fees,
     brokerage commissions and architectural fees, if any:

               7.12.3 Renovating or otherwise improving or decorating, painting
     or redecorating space for other tenants;

               7.12.4 Landlord's cost of electricity and any other services that
     are sold to other tenants and for which Landlord is entitled to
     reimbursement by such other tenants as an additional charge or rental over
     and above the base rent payable under the leases with such other tenants,
     if any;

               7.12.5 Costs incurred by Landlord for alterations, repairs,
     replacements or improvements which are considered capital alterations,
     repairs, replacements or improvements under generally accepted accounting
     principles, unless required by law or if anticipated to lower Operating
     Expenses;

               7.12.6 Expenses in connection with services or other benefits of
     a type which are not provided Tenant, but which are provided to another
     tenant or occupant, if any;

               7.12.7 Costs, fines or penalties incurred due to violation by
     Landlord or any other tenant of the terms and conditions of any lease, laws
     or regulations, if any;

               7.12.8 All items and services for which Tenant reimburses
     Landlord or pays third parties directly;

               7.12.9 Depreciation;

                                        9
<Page>

               7.12.10 Ground lease rental payments and principal or interest
     payments on loans secured by mortgages encumbering the Premises, or any
     costs incurred by Landlord in connection with such ground lease or loans,
     except as otherwise specifically permitted pursuant to this Section 7.12;

               7.12.11 Capital taxes, income taxes, corporate taxes, corporation
     capital taxes, excise taxes, profits taxes or other taxes personal to
     Landlord;

               7.12.12 Costs for investigating, monitoring, remediating or
     indemnifying for Hazardous Materials;

               7.12.13 Costs for repairing or maintaining the roof of the
     Building that: (i) constitute a capital improvement under generally
     accepted accounting principles or (ii) due to or a result of the Roof Lease
     or the System in connection with the Roof Lease;

               7.12.14 Any termination fee payable pursuant to Section 16.3 of
     the Roof Lease; and

               7.12.15 Costs for painting the exterior of the Building, except
     for painting as part of normal maintenance or as a result of actions or use
     of the Premises by Tenant or its employees, agents, contractors or
     invitees."

     15. TIMING FOR LANDLORD'S CONSENT TO SUBLEASE OR ASSIGNMENT. The following
sentence is hereby added to the end of Section 9.1 and shall read as follows:

         "If Landlord fails to respond to a request for Landlord's consent to a
     sublease or assignment within thirty (30) days after receipt of a notice
     from Tenant requesting such consent from Landlord, then in such event
     Landlord shall be deemed to have given its consent."

     16. SUBLEASE AND ASSIGNMENT RIGHTS. Section 9.8 is hereby added to the
Lease and shall read as follows:

         "Notwithstanding any other provisions hereof, Tenant (without
     obtaining Landlord's consent) shall have the right to freely transfer or
     assign the Lease and sublease all or part of the Premises: (i) to any
     entity which controls, is controlled by or is under common control with
     Tenant, (ii) to the surviving corporation in a merger or other corporate
     reorganization in which Tenant is involved or (iii) to any entity which
     acquires a majority of all the assets or capital stock of Tenant, provided
     that Tenant notifies Landlord of such transfer no later than thirty (30)
     days after such transfer."

     17. INDEMNITY. The following sentence is hereby added to the end of
Section 10:

         "Landlord will protect, indemnify and hold Tenant harmless from and
     against any and all loss, claims, liability or costs (including court costs
     and attorney's fees) incurred by reason of or arising out of: (a) any
     negligent act or omission of Landlord, its agents, employees, invitees or
     contractors, (b) any breach or default on the part of Landlord in the
     performance of any covenant or agreement on the part of Landlord to be
     performed pursuant to this Lease or (c) the Roof Lease, unless caused by
     Tenant or its employees, agents, contractors or invitees."

     18. INSURANCE. The following sentence is hereby added to the end of
Section 11.1:

         "Landlord may require a larger amount of insurance required above, in
     Landlord's reasonable judgment, two (2) times during the Extended Term,
     once for each of the Options."

                                       10
<Page>

     19.  LANDLORD INSURANCE. The following Section 11.4 is hereby to the Lease
and shall read as follows:

          "11.4.1 Landlord shall maintain All Risk Property Insurance upon the
     Building and other improvements to the Premises with coverage for perils as
     set forth on the Cause of Loss-Special Form, in an amount equal to full
     replacement cost. Such insurance shall contain an agreed valuation
     provision in lieu of any co-insurance clause, an increased cost of
     construction endorsement, debris removal coverage and a waiver of
     subrogation endorsement in favor of Tenant.

          11.4.2 Landlord shall maintain Commercial General Liability Insurance,
     including Contractual Liability Insurance coverage, covering Landlord's
     operations on the Premises, with combined single limits of
     not less than Two Million Dollars ($2,000,000) per occurrence for bodily
     injury or property damage, naming Tenant as an additional insured. Such
     insurance shall be endorsed to provide that the insurance shall be primary
     to and contributory to any similar insurance carried by Tenant, and shall
     contain a severability of interest clause.

          11.4.3 Landlord shall maintain Workers' Compensation Insurance
     providing statutory benefits to employees of Landlord in the State of
     California with a waiver of subrogation in favor of Tenant and Employer's
     Liability Insurance with limits of not less than One Hundred Thousand
     Dollars ($,100,000) per accident or disease and Five Hundred Thousand
     Dollars($500,000) aggregate by disease.

          11.4.4 Notwithstanding anything to the contrary above, in lieu of
     maintaining the insurance required under this Section 11.4: (i) the
     original Landlord, CalWest Industrial Properties, LLC, and (ii) any
     subsequent Landlord of the Premises, who has and maintains during the Term
     a net worth in excess of Fifty Million Dollars ($50,000,000) (as evidenced
     by Landlord's most recent financial statement) initially and increase three
     percent (3%) each year during the Term, may self insure for any of the
     insurance required to be carried by Landlord under this Lease. Tenant
     agrees not to disclose any financial statements received from Landlord and
     to keep such financial statements confidential. The carrying of any
     insurance by Landlord shall in no way be interpreted as relieving Tenant of
     any liability or responsibility under this Lease."

     20. ELECTRICITY. The following sentence is hereby added to the end of
Section 13:

          "Tenant shall be obligated to purchase energy generated by the System;
     provided, however: (i) in no event shall Tenant be obligated to pay more
     for such System energy than it would have otherwise had to pay for such
     energy if it had been purchased from San Diego Gas and Electric Company and
     (ii) Landlord pays for any writing, connections and /or hook up charges to
     the System at its sole cost and expense."

     21. SUBORDINATION. The following sentences are hereby added to the end of
Section 15:

          "Tenant hereby agrees to subordinate its rights hereunder to the
     interest of any ground lessor of the land upon which the Premises are
     situated and/or the lieu of any mortgage or deed of trust, hereafter in
     force, against the land and/or Building of which the Premises is a part;
     provided, however, that the ground lessor, or the mortgagee or trustee, as
     applicable, named in such mortgage or trust deed shall agree that Tenant's
     peaceable possession of the Premises will not be diminished on account
     thereof. In the event (i) any proceedings are brought for foreclosure, or
     (ii) of the exercise of the power of sale under any mortgage or deeds of
     trust, then, upon any such foreclosure or sale, Tenant agrees to recognize
     and attorn to such beneficiary or purchaser as Landlord under this Lease,
     provided that Tenant's right to possession under this Lease continues
     undiminished, subject to the terms and conditions of this Lease. Landlord
     agrees to attempt to obtain a

                                       11
<Page>

     commercially reasonable Subordination Non-Disturbance and Attornment
     Agreement ('SNDA') that does not conflict with the terms of this Lease from
     any future lender with a mortgage or deed of trust encumbering the Premises
     within thirty (30) days after Landlord obtains financing from such lender;
     provided that if such SNDA is not so delivered, Tenant shall not be
     required to subordinate its rights under this Lease to such future lender's
     mortgage or deed of trust."

     22. RE-ENTRY BY LANDLORD: CONFIDENTIALITY. The following sentences are
hereby added to the end of Section 16.1:

          "Landlord agrees to use commercially reasonable efforts to coordinate
     with Tenant the timing of inspections, alterations, improvements or repairs
     by Landlord concerning the Premises, so that such inspections, alterations,
     improvements or repairs are performed at a time that is reasonably
     satisfactory to Tenant. Landlord's right to re-enter the Premises as
     provided for in this Lease shall be conditioned upon Landlord giving to the
     Tenant reasonable advance notice, except in the case of emergencies. For
     purposes of this Lease reasonable advance notice shall mean that Tenant is
     entitled to at least twenty-four (24) hours notice, and Tenant may require
     additional time not to exceed five (5) business days as tenant deems
     necessary, provided Tenant acts in good faith to allow such re-entry
     promptly.

          Landlord agrees that environmental audits or inspections of the
     Premises shall be limited to Tenant's handling, transportation, storage,
     treatment and use of Hazardous Materials, together with its compliance with
     Environments Laws in connection therewith, and shall not be conducted more
     often than once a year, unless a problem has been identified that
     reasonably requires further inspections or in the event Landlord is
     notified of or has reasonable cause to believe that a release of Hazardous
     Materials at the Premises has occurred. Landlord acknowledges that the
     annual environmental audit that it performs normally: (i) does not result
     in a shutdown of a tenant's operations and (ii) does not last more than
     eight (8) hours.

          Landlord agrees, concurrently upon the execution of the Lease, to
     execute a confidentiality agreement in the form attached hereto as Exhibit
     D-1. Landlord further agrees that any persons conducting any inspections of
     the premises or otherwise entering the Premises shall be required, as a
     condition to entering the Premises, upon Tenant's request, to execute a
     confidentiality agreement in the form attached hereto as Exhibit D-2."

     23. ATTORNEYS FEES. The following sentences are hereby added to the end of
Section 18.2:

          "In the event of any controversy, claim or dispute between the parties
     hereto arising out of or relating to this Lease, including but not limited
     to a controversy settled by arbitration, the prevailing party shall be
     entitled to recover from the losing party reasonable expenses, attorneys'
     fees and costs. Any attorneys' fees of the prevailing party incurred in
     enforcing any judgment are recoverable as a separate item. This right to
     recover post-judgment attorneys' fees is intended to be severable from the
     other provisions of this Lease, to survive any judgment that may be entered
     in connection with or arising Lease, and is not to be deemed merged into
     any such judgment."

     24. DAMAGE: ELECTION BY TENANT. The following sentences are hereby added to
the end of Section 21.3 of the Lease and shall read as follows:

         "Notwithstanding anything to the contrary contained in this Section
     21.3, in the event that Land lord notifies Tenant of its election to
     terminate this Lease pursuant to this Section 21.3, Tenant may nevertheless
     elect to keep this Lease in full force and effect subject to the following
     terms and conditions: (i) Tenant so notifies Landlord of its election to
     keep this Lease in full force and effect within

                                       12
<Page>

     thirty (30) days after receiving Landlord's termination notice and (ii)
     Tenant covenants to repair such damage to the Premises or the Building in
     accordance with the terms and provisions of this Lease at its sole cost and
     expense, provided however, Landlord shall in such event make available to
     Tenant insurance proceeds, it any, received by Landlord as set forth below.

          Landlord shall disburse insurance proceeds, if any, to Tenant or
     Tenant's contractor based upon the percentage of completion of such repairs
     within thirty (30) days after receipt from Tenant or Tenant's contractor of
     a request for payment, together with copies of submitted invoices,
     certification from Tenant's architect concerning the appropriate percentage
     of work completed and all unconditional waiver and release upon progress
     payment for material and labor from Tenant's contractor, subcontractors and
     suppliers, subject to Landlord's reasonable verification concerning
     satisfaction of quality and the percentage of work completed as reasonably
     determined by the parties. The final ten percent (10%) of insurance
     proceeds held by Landlord, if any, shall be paid to Tenant or Tenant's
     contractor within sixty (60) days following proper recordation of a Notice
     of Completion for the repair work, and subject to satisfaction of the
     following conditions:

               21.3.1 Such repair work must have been completed in accordance
     with the Landlord approved final plans and specifications.

               21.3.2 Tenant has submitted a complete set of "as built" plans
     and specifications to Landlord.

               21.3.3 A final, unconditional certificate of occupancy for the
     Premises has been issued by the appropriate governmental agency, and a copy
     thereof provided to Landlord.

               21.3.4 Tenant has provided Landlord with properly executed
     mechanics lien releases in compliance with California Civil Code Section
     3262(d)(4) from Tenant's contractor, subcontractors and suppliers
     performing work in the Premises.

               21.3.5 Tenant has provided Landlord all construction warranties
     and guarantees in connection with the construction of the Tenant's Work to
     the extent obtained.

               21.3.6 Landlord has inspected and approved the Tenant's repair
     work and is reasonably satisfied that the Tenant's repair work has been
     performed in a good and workmanlike manner in accordance with the approved
     plans; provided, however, no such inspection shall impose any liability
     upon Landlord, nor absolve Tenant or Tenant's contractor from liability for
     any defect or failure to comply with the requirements hereof."

     25. DELAY IN REBUILDING. The following sentence is hereby added to the end
of Section 21.5:

          "However, in the event that such delay continues for more than three
     hundred and sixty-five (365) days (not counting those days of delay caused
     by Tenant or changes, deletions or additions in construction requested by
     Tenant), Tenant may terminate this Lease by written notice to Landlord
     prior to substantial completion of such repairs to the Premises."

     26. DAMAGE DURING LAST TWELVE MONTHS. Section 21.6 of the Lease is hereby
restated to read as follows:

          "Notwithstanding anything to the contrary contained in this Article 21
     Landlord shall not have any obligation whatsoever to repair, reconstruct,
     or restore the Premises when the damages resulting from any casualty
     covered by the

                                       13
<Page>

     provisions of this Article 21 occur during the last twelve (12) months of
     the Term or any extension thereof. If such damage to the Premises during
     the last twelve months of the Term or any extension thereof materially
     interferes with Tenant's use and occupancy of the Premises, in such event
     either party shall have the right to terminate this Lease by delivering
     written notice of termination to the other party within fifteen (15) days
     after such damage."

     27. ESTOPPEL CERTIFICATES. The following sentence is hereby added to the
end of Section 24:

          "Any statements by Tenant under Sections 24(d) or (e) above shall be
     limited to the best of Tenant's actual knowledge after reasonable inquiry
     and investigation, and Tenant shall have no liability for inaccuracies in
     such statements made under Sections 24(d) or (e) above unless Tenant knew
     such statements were inaccurate or, with reasonable inquiry and
     investigation, should have known such statement were inaccurate."

     28. JOINT INSPECTION. The first sentence of Section 25.1 is hereby restated
to read as follows:

          "At least thirty (30) days before the last day of the Term, each of
     the parties agrees to use diligent efforts to arrange a meeting with the
     other party at the Premises for a joint inspection of the Premises."

     29. SURRENDER OF PREMISES. The following sentence is hereby added to the
end of Section 25.3:

          "Tenant shall pay to Landlord within thirty (30) days after receipt of
     an invoice from Landlord the amount incurred by Landlord necessary to
     restore and repair the Premises as provided in the Lease and/or to
     discharge Tenant's obligation for unpaid amounts due or to become due to
     Landlord."

     30. AUTHORITY. The following sentences are hereby added to the end of
Section 29:

          "Landlord represents and warrants that Landlord has complied with all
     applicable laws, rules and governmental regulations relative to its right
     to do business in California and that Landlord is authorized to enter into
     this Lease. Landlord agrees to furnish promptly upon request appropriate
     documentation evidencing the due authorization of Landlord to enter into
     this Lease."

     31. ADDITIONAL PROVISIONS. The following provisions are hereby added to the
Lease:

          "37. SECURITY. Tenant hereby acknowledges that the rental payable to
     Landlord hereunder does not include the cost of guard service or other
     security measures, and that Landlord shall have no obligation whatsoever to
     provide same. Tenant assumes all responsibility for the protection of the
     Premises, Tenant, its agents and invitees and their property from the acts
     of third parties.

          38. SIGNAGE. Tenant may erect, maintain, and replace from time to time
     upon the Premises and the exterior of the Building including prominent
     building signage and signage at the front entrance to the project in the
     form of a directional sign to the Premises (subject to and in compliance
     with all applicable laws, ordinances, government rules or regulations and
     the CC&Rs), at Tenant's sole cost and expense, signs that Tenant deems
     appropriate to the conduct of its business and approved by Landlord, which
     approval will not be unreasonably withheld. Tenant shall maintain such
     signs in good order, condition and repair, and in compliance with all
     applicable laws, ordinances, government rules or regulations and the CC&Rs.

                                       14
<Page>

         39. PARKING

               39.1 Tenant, at no additional expense, shall be entitled to use
     the parking spaces associated with the Premises. All responsibility for
     damage and theft to vehicles is assumed by Tenant and Tenant's employees,
     visitors and customers. Tenant shall repair or cause to be repaired, at
     Tenant's sole cost and expense, any and all damage to the Premises caused
     by Tenant, or Tenant's employees', visitors' or customers' use of such
     parking areas. Any governmental charges or surcharges or other monetary
     obligations imposed relative to parking rights with respect to the Premises
     shall be payable by Tenant.

               39.2 Landlord reserves the right to change the entrances, exits,
     traffic lanes and boundaries and locations of the parking area for the
     Premises, provided such change is required by a government entity. Tenant,
     in the use of such parking areas, agrees to comply with reasonable rules
     and regulations for parking as Landlord may adopt form time to time for the
     orderly and proper operation of said parking areas, provided that such
     rules and regulations do not conflict with the terms of this Lease.

         40.   FINANCIAL STATEMENTS. Tenant acknowledges that it has provided
     Landlord with its financial statements as a material inducement to
     Landlord's agreement to lease the Premises to Tenant, and that Landlord has
     relied on the accuracy of said financial statements in entering into this
     Lease. Tenant represents and warrants that the information contained in
     said financial statements is true, complete and correct in all material
     aspects, and agrees that the foregoing representation and warranty shall be
     precondition to this Lease. At any time during the term of this Lease,
     within ten (10) days of Landlord's request, Tenant shall furnish to
     Landlord (if Tenant is not a publicly traded entity) financial statements
     of a similar nature for Tenant's most recent fiscal year available and
     shall represent and warrant the accuracy of such information.

         41.   EARLY TERMINATION. Tenant in its sole and absolute discretion may
     terminate this Lease by providing written notice to Landlord on or before
     July 31, 2001, which notice shall be accompanied by a termination fee equal
     to Four Hundred Thousand Dollars ($400,000) less the first month's rent
     paid to Landlord upon execution of this Lease. Additionally, Tenant may
     terminate this Lease by delivering to Landlord between August 1, 2001 and
     September 15, 2001 written notice of such termination, together with a
     termination fee equal to One Million Dollars ($1,000,000) less the first
     month's rent paid to Landlord upon execution of this Lease. In the even
     this Lease is terminated pursuant to Article 21 or Section 1.3 of this
     Lease, no termination fee shall be payable by Tenant.

         42. SQUARE FOOTAGE. Tenant has the right, at its sole cost, to measure
     the square footage of the Building. The parties agree that such measurement
     will be calculated based upon measurements taken from the exterior side of
     the outermost vertical surface of the exterior walls of the Building and as
     to the mezzanine, the measurements shall be taken of the actual deck
     surface area and for stairways, the entire area of the stairwell less that
     part of the stairs attached to the ground floor. Tenant shall have until
     May 30, 2001, to notify Landlord if it disagrees with Landlord's
     calculation of the square footage of the Building, set forth on the
     Reference Page of this Lease as the Building Rentable Area. If the parties
     agree on a Building Rentable Area different than that set forth on the
     Reference Page of this Lease, the parties shall recalculate the Initial
     Annual Rent and the Initial Monthly Installment of Annual Rent and execute
     an amendment to this Lease to memorialize such agreement and recalculation
     of rent. If the parties do not agree on the Building Rentable Area on or
     before June 8, 2001 the Building Rentable Area shall be determined in the
     following manner: Landlord and Tenant shall each appoint one (1) arbitrator
     who shall by profession by a

                                       15
<Page>

     qualified licensed architect or space planner specializing in industrial
     buildings in Southern California who shall have been active in such
     profession over the ten (10) year period ending on June 8, 2001. Each
     arbitrator shall be appointed by June 18, 2001. If within thirty (30) days
     after the arbitrators are appointed, the arbitrators are unable to agree
     upon the Building Rentable Area, then the two (2) arbitrators so appointed
     shall, within fifteen (15) days after expiration of said thirty (30) day
     period, agree upon and appoint a third arbitrator who shall be qualified
     under the same criteria set forth hereinabove for qualification of the
     initial two (2) arbitrators and who shall render a decision, within fifteen
     (15) days following his or her appointment, regarding the determination of
     the Building Rentable Area. The decision of the third arbitrator shall be
     binding upon Landlord and Tenant. If the two (2) arbitrators fail to agree
     upon and appoint a third arbitrator, the matter shall be decided forthwith
     by the American Arbitration Association pursuant to its Commercial
     Arbitration Rules. The cost of the arbitration shall be paid equally by
     Landlord and Tenant. If Tenant fails to notify Landlord on or before May
     30, 2001 that it disagrees with Landlord's calculation of the Building
     Rentable Area, then the Building Rentable Area set forth on the Reference
     Page of this Lease shall be conclusive and binding upon the parties. The
     Building Rentable Area shall not be increased in the event that Tenant
     enlarges the mezzanine of the Building or otherwise adds second story
     space in the Building."

     IN WITNESS WHEREOF, the parties have executed this Addendum as of the date
first above written.

<Table>
<S>                                                     <C>
LANDLORD                                                TENANT

CalWest Industrial Properties, LLC,                     Invitrogen Corporation, a Delaware corporation
a California Limited liability company

                                                        By:    /s/ John D. Thompson
By: RREEF AMERICA, L.L.C., a Delaware                          ----------------------------------------
limited liability company, its Manager                  Name:  John D. Thompson
                                                               ----------------------------------------
                                                        Title: Vice President
                                                               ----------------------------------------
By:   /s/ Michael F. Severson
      -------------------------------
Name: Michael F. Severson                               By:    /s/ John Cottingham
      -------------------------------                          ----------------------------------------
                                                        Name:  John Cottingham
Title: VP - Authorized Representative                          ----------------------------------------
      -------------------------------                   Title: Vice President, Gen. Counsel & Secretary
                                                               ----------------------------------------
</Table>

                                       16
<Page>

                                  EXHIBIT "D-1"

                      SITE VISIT CONFIDENTIALITY AGREEMENT

    This Confidentiality Agreement (the "Agreement") is entered into by and
between Invitrogen Corporation ("Invitrogen") and CalWest Industrial
Properties, LLC ("Participant"). In consideration of the mutual agreements
contained herein and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties, intending to be
legally bound, agree that:

1.  The discloser of Information is Invitrogen. The receiver of Information is
Participant.

2.  The parties' representatives for disclosing or receiving Information,
respectively, are: for Invitrogen: Troy Gardner or his/her designee; for
Participant: Jill Shanahan or his/her designee.

3.  Information disclosed under this agreement includes, but is not limited to,
the complete capability of the plants located on the site visited, including but
not limited to the facilities, the processes, the scale of operations both
individually and collectively, the technologies employed, the equipment
employed, including its scale and source, information relating to employee
training in quality and assurance, procedures for and record keeping of batch
records, and Invitrogen's plans for changing any or all of the foregoing.

4.  The burdens of nonuse and confidentiality on Participant will continue until
terminated by mutual agreement between the parties hereto.

5.  Participant will not use the Information except as is necessary or disclose
the Information to any person except its employees, consultants or
subcontractors, as is necessary in connection with Participant's maintenance,
repairs and inspections of the premises located at 5781 Van Allen Way, Carlsbad,
California in conjunction with and in accordance with that certain Lease dated
as of May 31, 2001 between Invitrogen and Participant, and any such disclosures
to consultants or subcontractors shall be under a written agreement with terms
at least as restrictive as those specified herein. Any of the persons mentioned
above who are given access to the Information shall be informed by the
Participant of this Agreement. Participant shall protect the Information by
using the same degree of care as Participant uses to protect its own
confidential Information, but in any event no less than a reasonable degree of
care.

6.  Participant's duties under this Agreement shall apply to any Information
received from Invitrogen by Participant, whether disclosed (i) orally, (ii)
visually, (iii) in a written document, memorandum, report, correspondence,
drawing or other material, computer-readable media, or (iv) in the form of
tangible products or materials.

7.  Notwithstanding any other provisions of this Agreement, Information
shall not include any item of information which: (a) is within the public domain
prior to the time of the disclosure by Invitrogen to Participant or thereafter
becomes within the public domain other than as a result of disclosure by
Participant or any of its representatives in violation of this Agreement; (b)
was, on or before the date of disclosure in the possession of Participant, as
evidenced by records, however maintained; (c) is acquired by Participant from a
third party not under an obligation of confidentiality; or (d) is hereafter
independently developed by Participant, as evidenced by records, however
maintained.

8.  In the event that Participant or anyone to whom it transmits the Information
pursuant to this agreement becomes legally required to disclose any such
Information, Participant shall provide Invitrogen with prompt notice so that
Invitrogen may seek a protective order or other appropriate remedy and/or waive
compliance with the provisions of this Agreement. In the event that such
protective order or other remedy is not obtained, Participant shall furnish only
that portion of the Information which is legally required to be furnished in the
opinion of Participant's counsel.

<Page>

9.  This Agreement is made under and shall be construed in accordance with the
laws of the State of California and constitutes the entire understanding between
the parties hereto with respect to the subject matter hereof and merges any and
all prior agreements, understandings and representations related to such subject
matter. This Agreement may not be superseded, amended or modified except by
written agreement between the parties hereto.

10. Each of the parties hereto has caused this Agreement to be executed on its
behalf by its authorized representative.

CALWEST INDUSTRIAL PROPERTIES,         INVITROGEN CORPORATION
LLC                                    1600 FARADAY AVENUE
                                       CARLSBAD, CALIFORNIA 92008

/s/ Michael F. Severson     6/11/01    /s/ John D. Thompson   June 6, 2001
-----------------------------------    -------------------------------------
AUTHORIZED SIGNATURE        DATE       AUTHORIZED SIGNATURE   DATE

MICHAEL F. SEVERSON         V.P.       John D. Thompson       Vice President
-----------------------------------    -------------------------------------
NAME                        TITLE      NAME                   TITLE

                                       2
<Page>

                                  EXHIBIT "D-2"

                      SITE VISIT CONFIDENTIALITY AGREEMENT

     This Confidentiality Agreement (the "Agreement") is entered into by and
between Invitrogen Corporation ("Invitrogen") and ______________________________
("Participant"). In consideration of the mutual agreements contained herein and
for other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the parties, intending to be legally bound, agree that:

1.   The Discloser of Information is Invitrogen. The Receiver of Information is
Participant.

2.   The parties' representatives for disclosing or receiving Information,
respectively, are: for Invitrogen: ___________________________ or his/her
designee; for Participant: _______________________ or his/her designee.

3.   Information disclosed under this Agreement includes, but is not limited to,
the complete capability of the plants located on the site visited, including but
not limited to the facilities, the processes, the scale of operations both
individually and collectively, the technologies employed, the equipment
employed, including its scale and source, information relating to employee
training in quality and assurance, procedures for and record keeping of batch
records, and Invitrogen's plans for changing any or all of the foregoing.

4.   The burdens of nonuse and confidentiality on Participant will continue
until terminated by mutual agreement between the parties hereto.

5.   Participant will not use the Information except as is necessary or
disclose the Information to any person except its employees, consultants
or subcontractors, as is necessary in connection with _________________________
_____________________________ Participant's __________________________________
_________________________________________________________________
___________________________________________________________ [e.g. conducting, or
having ________________ conduct, an environmental audit of the premises;
evaluating the premises as a prospective tenant/purchaser of the premises], and
any such disclosures to consultants or subcontractors shall be under a written
agreement with terms at least as restrictive as those specified herein. Any of
the persons mentioned above who are given access to the Information shall be
informed by the Participant of this Agreement. Participant shall protect its own
confidential Information, but in any event no less than a reasonable degree of
care.

6.   Participant's duties under this Agreement shall apply to any Information
received from Invitrogen by Participant, whether disclosed (i) orally, (ii)
visually, (iii) in a written document, memorandum, report, correspondence,
drawing or other material, computer-readable media, or (iv) in the form of
tangible products or materials.

7.   Notwithstanding any other provisions of this Agreement, Information
shall not include any item of information which: (a) is within the public domain
prior to the time of the disclosure by Invitrogen to Participant or thereafter
becomes within the public domain other than as a result of disclosure by
Participant or any of its representatives in violation of this Agreement; (b)
was, on or before the date of disclosure in the possession of Participant, as
evidenced by records, however maintained; (c) is acquired by Participant from a
third party not under an obligation of confidentiality; or (d) is hereafter
independently developed by Participant, as evidenced by records, however
maintained.

8.   In the event that Participant or anyone to whom it transmits the
Information pursuant to this Agreement becomes legally required to disclose any
such Information, Participant shall provide Invitrogen with prompt notice so
that Invitrogen may seek a protective order or other appropriate remedy and/or
waive compliance with the provisions of this Agreement. In the event that such
protective order or other remedy is not obtained, Participant shall furnish only
that

<Page>

portion of the Information which is legally required to be furnished in the
opinion of Participant's counsel.

9.   This Agreement is made under and shall be construed in accordance with the
laws of the State of California and constitutes the entire understanding between
the parties hereto with respect to the subject matter hereof and merges any and
all prior agreements, understandings and representations related to such subject
matter. This Agreement may not be superseded, amended or modified except by
written agreement between the parties hereto.

10.  Each of the parties hereto has caused this Agreement to be executed on its
behalf by its authorized representative.

-----------------------------------    INVITROGEN CORPORATION
-----------------------------------    1600 FARADAY AVENUE
-----------------------------------    CARLSBAD, CALIFORNIA 92008

-----------------------------------    -------------------------------
AUTHORIZED SIGNATURE    DATE           AUTHORIZED SIGNATURE  DATE

-----------------------------------    -------------------------------
NAME                    TITLE          NAME                  TITLE

                                       2<Page>

     UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE
DEPOSITORY TRUST COMPANY TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF
TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE
NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE
TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER
USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

     THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE
HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A
NOMINEE THEREOF. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE
NAME OF A PERSON OTHER THAN THE DEPOSITARY OR ITS NOMINEE ONLY IN THE LIMITED
CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND, UNLESS AND UNTIL IT IS EXCHANGED
IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM, THIS SECURITY MAY NOT BE
TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY
OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE
DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR
A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.

     THIS SECURITY (OR ITS PREDECESSOR) WAS ORIGINALLY ISSUED IN A TRANSACTION
EXEMPT FROM REGISTRATION UNDER THE UNITED STATES SECURITIES ACT OF 1933 (THE
"SECURITIES ACT"), AND THIS SECURITY AND THE SHARES OF COMMON STOCK ISSUABLE
UPON CONVERSION THEREOF MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED IN THE
ABSENCE OF SUCH REGISTRATION OR AN APPLICABLE EXEMPTION THEREFROM, EACH
PURCHASER OF THIS SECURITY IS HEREBY NOTIFIED THAT THE SELLER OF THIS SECURITY
MAY BE RELYING ON THE EXEMPTION FROM THE PROVISIONS OF SECTION 5 OF THE
SECURITIES ACT PROVIDED BY RULE 144A THEREUNDER.

     THE HOLDER OF THIS SECURITY AGREES FOR THE BENEFIT OF THE COMPANY THAT (A)
THIS SECURITY AND THE SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION THEREOF
MAY BE OFFERED, RESOLD, PLEDGED OR OTHERWISE TRANSFERRED, ONLY (I) IN THE UNITED
STATES TO A PERSON WHOM THE SELLER REASONABLY BELIEVES IS A QUALIFIED
INSTITUTIONAL BUYER (AS DEFINED IN RULE 144A UNDER THE SECURITIES ACT) IN A
TRANSACTION MEETING THE REQUIREMENTS OF RULE 144A, (II) OUTSIDE THE UNITED
STATES IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH RULE 904 UNDER THE
SECURITIES ACT, (III) PURSUANT TO AN EXEMPTION FROM REGISTRATION UNDER THE
SECURITIES ACT PROVIDED BY RULE 144 THEREUNDER (IF AVAILABLE) OR (IV) PURSUANT
TO

<Page>

AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, IN EACH OF
CASES (I) THROUGH (IV) IN ACCORDANCE WITH ANY APPLICABLE SECURITIES LAWS OF ANY
STATE OF THE UNITED STATES, AND (B) THE HOLDER WILL, AND EACH SUBSEQUENT HOLDER
IS REQUIRED TO, NOTIFY ANY PURCHASER OF THIS SECURITY FROM IT OF THE RESALE
RESTRICTIONS REFERRED TO IN (A) ABOVE.

     THE HOLDER OF THIS SECURITY IS ENTITLED TO THE BENEFITS OF A REGISTRATION
RIGHTS AGREEMENT (AS SUCH TERM IS DEFINED IN THE INDENTURE REFERRED TO ON THE
REVERSE HEREOF) AND, BY ITS ACCEPTANCE HEREOF, AGREES TO BE BOUND BY AND TO
COMPLY WITH THE PROVISIONS OF SUCH REGISTRATION RIGHTS AGREEMENT.

<Page>

                             INVITROGEN CORPORATION

CUSIP No.:  46185R AC4

                 2 1/4% CONVERTIBLE SUBORDINATED NOTES DUE 2006

     Invitrogen Corporation, a Delaware corporation (the "Company", which term
shall include any successor corporation under the Indenture referred to on the
reverse hereof), promises to pay to Cede & Co., or registered assigns, the
principal sum of Five Hundred Million Dollars ($500,000,000.00) on December 15,
2006, or such greater or lesser amount as is indicated on the Schedule of
Exchanges of Notes on the other side of this Note.

Interest Payment Dates:    June 15 and December 15, commencing June 15, 2002

Record Dates:              June 1 and December 1

     This Note is convertible as specified on the other side of this Note.
Additional provisions of this Note are set forth on the other side of this Note.

                             SIGNATURE PAGE FOLLOWS

<Page>

     IN WITNESS WHEREOF, the Company has caused this instrument to be duly
executed.

                                      INVITROGEN CORPORATION

                                      By:
                                            ------------------------------
                                      Name:
                                      Title:

Attest:

------------------------------
Name:
Title:

Dated:   December 11, 2001

TRUSTEE'S CERTIFICATE OF AUTHENTICATION
This is one of the Securities referred to
in the within-mentioned Indenture.

STATE STREET BANK AND TRUST COMPANY OF CALIFORNIA, NATIONAL ASSOCIATION, as
Trustee

By:
     ------------------------------
          Authorized Signatory

<Page>

                             INVITROGEN CORPORATION

                 2 1/4% CONVERTIBLE SUBORDINATED NOTES DUE 2006

     1.    INTEREST. Invitrogen Corporation, a Delaware corporation (the
"Company", which term shall include any successor corporation under the
Indenture hereinafter referred to), promises to pay interest on the principal
amount of this Note at the rate of 2 1/4% per annum. The Company shall pay
interest semiannually on June 15 and December 15 of each year, commencing on
June 15, 2002. Interest on the Notes shall accrue from the most recent date to
which interest has been paid or, if no interest has been paid, from December 11,
2001; PROVIDED, HOWEVER, that if there is not an existing default in the payment
of interest and if this Note is authenticated between a record date referred to
on the face hereof and the next succeeding interest payment date, interest shall
accrue from such interest payment date. Interest will be computed on the basis
of a 360-day year of twelve 30-day months.

     2.    REGISTRATION RIGHTS AGREEMENT. The holder of this Note is entitled to
the benefits of a Registration Rights Agreement, dated as of December 11, 2001,
among the Company and the Initial Purchasers (the "Registration Rights
Agreement"). Pursuant to the Registration Rights Agreement the Company has
agreed for the benefit of the Holders of the Notes, that (i) it will, at its
cost, within 90 days after the closing of the sale of the Notes (the "Closing"),
file a shelf registration statement (the "Shelf Registration Statement") with
the Securities and Exchange Commission (the "Commission") with respect to
resales of the Notes and the Common Stock issuable upon conversion thereof, (ii)
it will use its reasonable best efforts to cause such Shelf Registration
Statement to be declared effective within 180 days after the Closing, and (iii)
it will use its best efforts to keep such Shelf Registration Statement
continuously effective under the Securities Act, subject to certain exceptions
specified in the Registration Rights Agreement until the second anniversary of
the date of the Closing. As set forth in the Registration Rights Agreement, the
Company will be permitted to suspend use of the prospectus that is part of the
Shelf Registration Statement during certain periods of time and in certain
circumstances relating to pending corporate developments and public filings with
the SEC and similar events. If (a) the Company fails to file the Shelf
Registration Statement required by the Registration Rights Agreement on or
before the date specified above for such filing, (b) such Shelf Registration
Statement is not declared effective by the Commission on or prior to the date
specified above for such effectiveness, or (c) the Shelf Registration Statement
is declared effective but thereafter ceases to be effective or useable in
connection with resales of Transfer Restricted Securities (as defined in the
Registration Rights Agreement) during the periods specified in the Registration
Rights Agreement (each such event referred to in clauses (a) through (c) above a
"Registration Default"), then the Company will pay Special Interest to each
Holder of Transfer Restricted Securities, with respect to the first 90-day
period immediately following the occurrence of such Registration Default in an
amount equal to an increase in the annual interest rate on the Notes of 0.25%
("Special Interest") and with respect to each subsequent 90-day period,
additional amounts equal to an increase in the annual interest rate on the Notes
of 0.25% until all Registration Defaults have been cured, up to a maximum
increase in the annual interest rate on the Notes equal to 1.0%. All accrued
Special Interest shall be paid by the Company on each Interest Payment Date for
which Special Interest is owed to the holders of Global Notes by wire transfer
of immediately available funds or by federal funds check and to holders of
certificated Notes registered as such as of the preceding Record Date by mailing
checks to their registered

                                       2
<Page>

addresses. Following the cure of all Registration Defaults, the application of
Special Interest will cease.

     3.    METHOD OF PAYMENT. The Company shall pay interest on this Note
(except defaulted interest) to the person who is the Holder of this Note at
the close of business on June 1 or December 1, as the case may be, next
preceding the related interest payment date. The Holder must surrender this Note
to a Paying Agent to collect payment of principal. The Company will pay
principal and interest in money of the United States that at the time of payment
is legal tender for payment of public and private debts. The Company may,
however, pay principal and interest in respect of any Certificated Security by
check or wire payable in such money; PROVIDED, HOWEVER, that a Holder with an
aggregate principal amount in excess of $2,000,000 will be paid by wire transfer
in immediately available funds at the election of such Holder if such Holder has
provided wire transfer instructions to the Company at least 10 Business Days
prior to the payment date.

     The Company may mail an interest check to the Holder's registered address.
Notwithstanding the foregoing, so long as this Note is registered in the name of
a Depositary or its nominee, all payments hereon shall be made by wire transfer
of immediately available funds to the account of the Depositary or its nominee.

     4.    PAYING AGENT, REGISTRAR AND CONVERSION AGENT. Initially, State Street
Bank and Trust Company of California, National Association (the "Trustee", which
term shall include any successor trustee under the Indenture hereinafter
referred to) will act as Paying Agent, Registrar and Conversion Agent. The
Company may change any Paying Agent, Registrar or Conversion Agent without
notice to the Holder. The Company or any of its Subsidiaries may, subject to
certain limitations set forth in the Indenture, act as Paying Agent or
Registrar.

     5.    INDENTURE, LIMITATIONS. This Note is one of a duly authorized issue
of Securities of the Company designated as its 2 1/4% Convertible Subordinated
Notes due 2006 (the "Notes"), issued under an Indenture dated as of December 11,
2001 (together with any supplemental indentures thereto, the "Indenture"),
between the Company and the Trustee. The terms of this Note include those stated
in the Indenture and those required by or made part of the Indenture by
reference to the Trust Indenture Act of 1939, as amended, as in effect on the
date of the Indenture. This Note is subject to all such terms, and the Holder of
this Note is referred to the Indenture and said Act for a statement of them. The
Notes are subordinated unsecured obligations of the Company limited to
$600,000,000 aggregate principal amount. The Indenture does not limit other debt
of the Company, secured or unsecured, including Senior Indebtedness.

     6.    OPTIONAL REDEMPTION. The Notes are subject to redemption, at any time
on or after December 20, 2005, as a whole or from time to time in part, at the
election of the Company. The Redemption Price is 100% of the principal amount
together with accrued interest up to but not including the Redemption Date;
PROVIDED THAT if the Redemption Date falls after an interest payment record date
and on or before an interest payment date, then the interest will be payable to
the Holders in whose names the Notes are registered at the close of business on
the relevant interest payment record dates. No sinking fund is provided for the
Notes.

<Page>

     7.    NOTICE OF REDEMPTION. Notice of redemption will be mailed by
first-class mail at least 20 days but not more than 60 days before the
Redemption Date to each Holder of Notes to be redeemed at its registered
address. Notes in denominations larger than $1,000 may be redeemed in part, but
only in whole multiples of $1,000. On and after the Redemption Date, subject to
the deposit with the Paying Agent of funds sufficient to pay the Redemption
Price plus accrued interest, if any, accrued to, but excluding, the Redemption
Date, interest shall cease to accrue on Notes or portions of them called for
redemption.

     8.    PURCHASE OF NOTES AT OPTION OF HOLDER UPON A CHANGE IN CONTROL. At
the option of the Holder and subject to the terms and conditions of the
Indenture, the Company shall become obligated to purchase all or any part
specified by the Holder (so long as the principal amount of such part is $1,000
or an integral multiple of $1,000 in excess thereof) of the Notes held by such
Holder at a purchase price equal to 100% of the principal amount thereof
together with accrued interest up to, but excluding, the Change in Control
Purchase Date. The Holder shall have the right to withdraw any Change in Control
Purchase Notice (in whole or in a portion thereof that is $1,000 or an integral
multiple of $1,000 in excess thereof) at any time prior to the close of business
on the second Business Day next preceding the Change in Control Purchase Date by
delivering a written notice of withdrawal to the Company, Depositary or Paying
Agent in accordance with the terms of the Indenture.

     9.    CONVERSION. A Holder of a Note may convert the principal amount of
such Note (or any portion thereof equal to $1,000 or any integral multiple of
$1,000 in excess thereof) into Common Stock at any time prior to the close of
business on the Final Maturity Date, at the Conversion Price then in effect;
PROVIDED, HOWEVER, that, if such Note is called for redemption or submitted or
presented for purchase pursuant to Article 3 of the Indenture, such conversion
right shall terminate at the close of business on the Business Day immediately
preceding the Redemption Date or Change in Control Purchase Date, as the case
may be, for such Note or such earlier date as the Holder presents such Security
for redemption or for purchase (unless the Company shall default in making the
redemption payment or Change in Control Purchase Price payment when due, in
which case the conversion right shall terminate at the close of business on the
date such default is cured and such Note is redeemed or purchased, as the case
may be).

     The initial Conversion Price is $86.10 per share, subject to adjustment
under certain circumstances as provided in the Indenture. The number of shares
of Common Stock issuable upon conversion of a Note is determined by dividing the
principal amount of the Note or portion thereof converted by the Conversion
Price in effect on the Conversion Date. No fractional shares will be issued upon
conversion; in lieu thereof, an amount will be paid in cash based upon the
Closing Price (as defined in the Indenture) of the Common Stock on the Trading
Day immediately prior to the Conversion Date. To convert a Note, a Holder must
(a) complete and manually sign the conversion notice set forth below and deliver
such notice to a Conversion Agent, (b) surrender the Note to a Conversion Agent,
(c) furnish appropriate endorsements and transfer documents if required by a
Registrar or a Conversion Agent, and (d) pay any transfer or similar tax, if
required. Notes so surrendered for conversion (in whole or in part) during the
period from the close of business on any regular record date to the opening of
business on the next succeeding interest payment date (excluding Notes or
portions thereof called for redemption or subject to purchase upon a Change in
Control on a Redemption Date or Change in Control Purchase Date, as the case may
be, during the period beginning at the close of business on a

<Page>

regular record date and ending at the opening of business on the first Business
Day after the next succeeding interest payment date, or if such interest payment
date is not a Business Day, the second such Business Day) shall also be
accompanied by payment in funds acceptable to the Company of an amount equal to
the interest payable on such interest payment date on the principal amount of
such Note then being converted, and such interest shall be payable to such
registered Holder notwithstanding the conversion of such Note, subject to the
provisions of this Indenture relating to the payment of defaulted interest by
the Company. If the Company defaults in the payment of interest payable on such
interest payment date, the Company shall promptly repay such funds to such
Holder. A Holder may convert a portion of a Note equal to $1,000 or any integral
multiple thereof. A Note in respect of which a Holder had delivered a Change in
Control Purchase Notice exercising the option of such Holder to require the
Company to purchase such Note may be converted only if the Change in Control
Purchase Notice is withdrawn in accordance with the terms of the Indenture.

     10.   CONVERSION ARRANGEMENT ON CALL FOR REDEMPTION. Any Notes called for
redemption, unless surrendered for conversion before the close of business on
the Business Day immediately preceding the Redemption Date, may be deemed to be
purchased from the Holders of such Notes at an amount not less than the
Redemption Price, together with accrued interest, if any, to, but not including,
the Redemption Date, by one or more investment bankers or other purchasers who
may agree with the Company to purchase such Notes from the Holders, to convert
them into Common Stock of the Company and to make payment for such Notes to the
Paying Agent in trust for such Holders.

     11.   SUBORDINATION. The indebtedness evidenced by the Notes is, to the
extent and in the manner provided in the Indenture, subordinate and junior in
right of payment to the prior payment in full of all Senior Indebtedness of the
Company. Any Holder by accepting this Note agrees to and shall be bound by such
subordination provisions and authorizes the Trustee to give them effect. In
addition to all other rights of Senior Indebtedness described in the Indenture,
the Senior Indebtedness shall continue to be Senior Indebtedness and entitled to
the benefits of the subordination provisions irrespective of any amendment,
modification or waiver of any terms of any instrument relating to the Senior
Indebtedness or any extension or renewal of the Senior Indebtedness.

     12.   DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form,
without coupons, in denominations of $1,000 and integral multiples of $1,000. A
Holder may register the transfer of or exchange Notes in accordance with the
Indenture. The Registrar may require a Holder, among other things, to furnish
appropriate endorsements and transfer documents and to pay any taxes or other
governmental charges that may be imposed in relation thereto by law or permitted
by the Indenture.

     13.   PERSONS DEEMED OWNERS. The Holder of a Note may be treated as the
owner of it for all purposes.

     14.   UNCLAIMED MONEY. If money for the payment of principal or interest
remains unclaimed for two years, the Trustee or Paying Agent will pay the money
back to the Company at its written request, subject to applicable unclaimed
property law. After that, Holders entitled

<Page>

to money must look to the Company for payment as general creditors unless an
applicable abandoned property law designates another person.

     15.   AMENDMENT, SUPPLEMENT AND WAIVER. Subject to certain exceptions, the
Indenture or the Notes may be amended or supplemented with the consent of the
Holders of at least a majority in aggregate principal amount of the Notes then
outstanding, and an existing default or Event of Default and its consequence or
compliance with any provision of the Indenture or the Notes may be waived in a
particular instance with the consent of the Holders of a majority in aggregate
principal amount of the Notes then outstanding. Without the consent of or notice
to any Holder, the Company and the Trustee may amend or supplement the Indenture
or the Notes to, among other things, cure any ambiguity, defect or inconsistency
or make any other change that does not adversely affect the rights of any
Holder.

     16.   SUCCESSOR ENTITY. When a successor corporation assumes all the
obligations of its predecessor under the Notes and the Indenture in accordance
with the terms and conditions of the Indenture, the predecessor corporation
(except in certain circumstances specified in the Indenture) shall be released
from those obligations.

     17.   DEFAULTS AND REMEDIES. Under the Indenture, an Event of Default
includes: (i) default for 30 days in payment of any interest or Special Interest
on any Notes; (ii) default in payment of any principal (including, without
limitation, any premium, if any) on the Notes when due; (iii) failure by the
Company for 60 days after notice to it to comply with any of its other
agreements contained in the Indenture or the Notes; (iv) default in the payment
of certain indebtedness of the Company or a Significant Subsidiary; (v) the
Company fails to provide a Purchase Offer within 30 days after notice of failure
to timely deliver the same; and (vi) certain events of bankruptcy, insolvency or
reorganization of the Company or any Significant Subsidiary. If an Event of
Default (other than as a result of certain events of bankruptcy, insolvency or
reorganization of the Company) occurs and is continuing, the Trustee or the
Holders of at least 25% in aggregate principal amount of the Notes then
outstanding may declare all unpaid principal to the date of acceleration on the
Notes then outstanding to be due and payable immediately, all as and to the
extent provided in the Indenture. If an Event of Default occurs as a result of
certain events of bankruptcy, insolvency or reorganization of the Company,
unpaid principal of the Notes then outstanding shall become due and payable
immediately without any declaration or other act on the part of the Trustee or
any Holder, all as and to the extent provided in the Indenture. Holders may not
enforce the Indenture or the Notes except as provided in the Indenture. The
Trustee may require indemnity satisfactory to it before it enforces the
Indenture or the Notes. Subject to certain limitations, Holders of a majority in
aggregate principal amount of the Notes then outstanding may direct the Trustee
in its exercise of any trust or power. The Trustee may withhold from Holders
notice of any continuing default (except a default in payment of principal or
interest) if it determines that withholding notice is in their interests. The
Company is required to file periodic reports with the Trustee as to the absence
of default.

     18.   TRUSTEE DEALINGS WITH THE COMPANY. State Street Bank and Trust
Company of California, National Association, the Trustee under the Indenture, in
its individual or any other capacity, may make loans to, accept deposits from
and perform services for the Company or an

<Page>

Affiliate of the Company, and may otherwise deal with the Company or an
Affiliate of the Company, as if it were not the Trustee.

     19.   NO RECOURSE AGAINST OTHERS. A director, officer, employee or
shareholder, as such, of the Company shall not have any liability for any
obligations of the Company under the Notes or the Indenture nor for any claim
based on, in respect of or by reason of such obligations or their creation. The
Holder of this Note by accepting this Note waives and releases all such
liability. The waiver and release are part of the consideration for the issuance
of this Note.

     20.   AUTHENTICATION. This Note shall not be valid until the Trustee or an
authenticating agent manually signs the certificate of authentication on the
other side of this Note.

     21.   ABBREVIATIONS AND DEFINITIONS. Customary abbreviations may be used in
the name of the Holder or an assignee, such as: TEN COM (= tenants in common),
TEN ENT (- tenants by the entireties), JT TEN (= joint tenants with right of
survivorship and not as tenants in common), CUST (= Custodian) and UGMA (=
Uniform Gifts to Minors Act). All terms defined in the Indenture and used in
this Note but not specifically defined herein are defined in the Indenture and
are used herein as so defined.

     22.   INDENTURE TO CONTROL; GOVERNING LAW. In the case of any conflict
between the provisions of this Note and the Indenture, the provisions of the
Indenture shall control. This Note shall be governed by, and construed in
accordance with, the laws of the State of New York, without regard to principals
of conflicts of law.

     The Company will furnish to any Holder, upon written request and without
charge, a copy of the Indenture. Requests may be made to: Invitrogen
Corporation, 1600 Faraday Avenue, Carlsbad, California 92008, Attention:
Investor Relations.

<Page>

                                 ASSIGNMENT FORM

To assign this Note, fill in the form below:
I or we assign and transfer this Note to

--------------------------------------------------------------------------------
                 (Insert assignee's soc. sec. or tax I.D. no.)

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
             (Print or type assignee's name, address and zip code)

and irrevocably appoint

--------------------------------------------------------------------------------

agent to transfer this Note on the books of the Company. The agent may
substitute another to act for him or her.

                                          Your Signature:

Date:
      -------------------------------    -------------------------------------
                                          (Sign exactly as your name appears on
                                          the other side of this Note)

*Signature guaranteed by:

By:
    ---------------------------------

          *  The signature must be guaranteed by an institution which is a
             member of one of the following recognized signature guaranty
             programs: (i) the Securities Transfer Agent Medallion Program
             (STAMP); (ii) the New York Stock Exchange Medallion Program (MSP);
             (iii) the Stock Exchange Medallion Program (SEMP); or (iv) such
             other guaranty program acceptable to the Trustee.

<Page>

                                CONVERSION NOTICE

To convert this Note into Common Stock of the Company, check the box: / /
To convert only part of this Note, state the principal amount to be converted
(must be $1,000 or a integral multiple of $1,000): $____________.
If you want the stock certificate made out in another person's name, fill in the
form below:

--------------------------------------------------------------------------------
                 (Insert assignee's soc. sec. or tax I.D. no.)

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
             (Print or type assignee's name, address and zip code)

                                          Your Signature:

Date:
      -------------------------------     -------------------------------------
                                          (Sign exactly as your name appears on
                                          the other side of this Note)

*Signature guaranteed by:

By:
    ---------------------------------

          *  The signature must be guaranteed by an institution which is a
             member of one of the following recognized signature guaranty
             programs: (i) the Securities Transfer Agent Medallion Program
             (STAMP); (ii) the New York Stock Exchange Medallion Program (MSP);
             (iii) the Stock Exchange Medallion Program (SEMP); or (iv) such
             other guaranty program acceptable to the Trustee.

<Page>

                           OPTION TO ELECT REPURCHASE
                            UPON A CHANGE OF CONTROL

To:   Invitrogen Corporation

      The undersigned registered owner of this Security hereby irrevocably
acknowledges receipt of a notice from Invitrogen Corporation (the "Company") as
to the occurrence of a Change in Control with respect to the Company and
requests and instructs the Company to redeem the entire principal amount of this
Security, or the portion thereof (which is $1,000 or an integral multiple
thereof) below designated, in accordance with the terms of the Indenture
referred to in this Security at the Change in Control Purchase Price, together
with accrued interest to, but excluding, such date, to the registered Holder
hereof.

Dated:
      -------------                       ------------------------------------

                                          ------------------------------------

                                          Signature(s) must be guaranteed by a
                                          qualified guarantor institution with
                                          membership in an approved signature
                                          guarantee program pursuant to Rule
                                          17Ad-15 under the Securities Exchange
                                          Act of 1934.

                                          ------------------------------------
                                          Signature Guaranty
Principal amount to be redeemed
(in an integral multiple of $1,000,
if less than all):

----------------------------------
NOTICE: The signature to the foregoing Election must correspond to the Name as
written upon the face of this Security in every particular, without alteration
or any change whatsoever.

<Page>

                         SCHEDULE OF EXCHANGES OF NOTES

The following exchanges, redemptions, repurchases or conversions of a part of
this global Note have been made:

<Table>
<Caption>
         PRINCIPAL AMOUNT
       OF THIS GLOBAL NOTE          AUTHORIZED                                  AMOUNT OF
          FOLLOWING SUCH           SIGNATORY OF    AMOUNT OF DECREASE IN       INCREASE IN
          DECREASE DATE             SECURITIES        PRINCIPAL AMOUNT       PRINCIPAL AMOUNT
     OF EXCHANGE (OR INCREASE)      CUSTODIAN       OF THIS GLOBAL NOTE     OF THIS GLOBAL NOTE
     --------------------------    -------------   ----------------------   ---------------------
     <S>                           <C>              <C>                     <C>
</Table>

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