Document:

exv10w15

 

Exhibit 10.15

ADNEXUS THERAPEUTICS, INC.

Incentive Stock Option Agreement

Granted Under 2002 Stock Incentive Plan

1. Grant of Option.

     This agreement evidences the grant by Adnexus Therapeutics, Inc., a Delaware corporation (the
“Company”), on   , 200[ ] (the “Grant Date”) to [     ], an
employee of the Company (the “Participant”), of an option to purchase, in whole or in part, on the
terms provided herein and in the Company’s 2002 Stock Incentive Plan (the “Plan”), a total of [
    ] shares (the “Shares”) of common stock, $.001 par value per share, of the
Company (“Common Stock”) at $[     ] per Share. Unless earlier terminated, this
option shall expire on [___] (the “Final Exercise Date”) [ten years from date of grant].

     It is intended that the option evidenced by this agreement shall be an incentive stock option
as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any regulations
promulgated thereunder (the “Code”). Except as otherwise indicated by the context, the term
“Participant”, as used in this option, shall be deemed to include any person who acquires the right
to exercise this option validly under its terms.

2. Vesting Schedule.

     (a) This option will become exercisable (“vest”) as to 25% of the original number of Shares on
the first anniversary of the Vesting Commencement Date (as defined below) and as to an additional
6.25% of the original number of Shares at the end of each successive three-month period following
the first anniversary of the Vesting Commencement Date until the fourth anniversary of the Vesting
Commencement Date. For purposes of this Agreement, the “Vesting Commencement Date” shall mean
                    , 200_.

     (b) The right of exercise shall be cumulative so that to the extent the option is not
exercised in any period to the maximum extent permissible it shall continue to be exercisable, in
whole or in part, with respect to all shares for which it is vested until the earlier of the Final
Exercise Date or the termination of this option under Section 3 hereof or the Plan.

     (c) Upon the occurrence of a Sale (as defined below) of the Company, the vesting of this
option under Section 2(a) above shall be accelerated in part so that option shall become
exercisable for an additional number of shares equal to 25% of the then unvested Shares. This
option shall continue to vest with respect to the remaining unvested Shares in accordance with
Section 2(a) above.

3. Exercise of Option.

     (a) Form of Exercise. Each election to exercise this option shall accompanied by a
completed Notice of Stock Option Exercise in the form attached hereto as Exhibit A, signed
by the Participant, and received by the Company at its principal office, accompanied by this
agreement, and payment in full in the manner provided in the Plan. The Participant may

 

 

purchase less than the number of shares covered hereby, provided that no partial exercise of
this option may be for any fractional share or for fewer than ten whole shares.

     (b) Continuous Relationship with the Company Required. Except as otherwise provided
in this Section 3, this option may not be exercised unless the Participant, at the time he or she
exercises this option, is, and has been at all times since the Grant Date, an employee, officer or
director of, or consultant or advisor to, the Company or any parent or subsidiary of the Company as
defined in Section 424(e) or (f) of the Code (an “Eligible Participant”).

     (c) Termination of Relationship with the Company. If the Participant ceases to be an
Eligible Participant for any reason, then, except as provided in paragraphs (d) and (e) below, the
right to exercise this option shall terminate three months after such cessation (but in no event
after the Final Exercise Date), provided that this option shall be exercisable only
to the extent that the Participant was entitled to exercise this option on the date of such
cessation. Notwithstanding the foregoing, if the Participant, prior to the Final Exercise Date,
violates the non-competition or confidentiality provisions of any employment contract,
confidentiality and nondisclosure agreement or other agreement between the Participant and the
Company, the right to exercise this option shall terminate immediately upon such violation.

     (d) Exercise Period Upon Death or Disability. If the Participant dies or becomes
disabled (within the meaning of Section 22(e)(3) of the Code) prior to the Final Exercise Date
while he or she is an Eligible Participant and the Company has not terminated such relationship for
“cause” as specified in paragraph (e) below, this option shall be exercisable, within the period of
one year following the date of death or disability of the Participant, by the Participant (or in
the case of death by an authorized transferee), provided that this option shall be
exercisable only to the extent that this option was exercisable by the Participant on the date of
his or her death or disability, and further provided that this option shall not be exercisable
after the Final Exercise Date.

     (e) Discharge for Cause. If the Participant, prior to the Final Exercise Date, is
discharged by the Company for “cause” (as defined below), the right to exercise this option shall
terminate immediately upon the effective date of such discharge. “Cause” shall mean willful
misconduct by the Participant or willful failure by the Participant to perform his or her
responsibilities to the Company (including, without limitation, breach by the Participant of any
provision of any employment, consulting, advisory, nondisclosure, non-competition or other similar
agreement between the Participant and the Company), as determined by the Company, which
determination shall be conclusive. The Participant shall be considered to have been discharged for
“Cause” if the Company determines, within 30 days after the Participant’s resignation, that
discharge for cause was warranted.

4. Right of First Refusal and Restrictions on Transfer.

     (a) If the Participant proposes to sell, assign, transfer, pledge, hypothecate or otherwise
dispose of, by operation of law or otherwise (collectively, “transfer”) any Shares acquired upon
exercise of this option, then the Participant shall first give written notice of the proposed
transfer (the “Transfer Notice”) to the Company. The Transfer Notice shall name the

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proposed transferee and state the number of such Shares the Participant proposes to transfer
(the “Offered Shares”), the price per share and all other material terms and conditions of the
transfer.

     (b) For 60 days following its receipt of such Transfer Notice, the Company shall have the
option to purchase some or all of the Offered Shares at the price and upon the terms set forth in
the Transfer Notice. In the event the Company elects to purchase any Offered Shares (the Offered
Shares to be purchased by the Company hereunder are referred to as the “Purchased Shares”), it
shall give written notice of such election to the Participant within such 60-day period. Within 10
days after his receipt of such notice, the Participant shall tender to the Company at its principal
offices the certificate or certificates representing the Purchased Shares, duly endorsed in blank
by the Participant or with duly endorsed stock powers attached thereto, all in a form suitable for
transfer of the Purchased Shares to the Company. Promptly following receipt of such certificate or
certificates, the Company shall deliver or mail to the Participant a check in payment of the
purchase price for the Purchased Shares; provided that if the terms of payment set
forth in the Transfer Notice were other than cash against delivery, the Company may pay for the
Purchased Shares on the same terms and conditions as were set forth in the Transfer Notice; and
provided further that any delay in making such payment shall not invalidate the
Company’s exercise of its option to purchase the Purchased Shares.

     (c) If the Company does not elect to acquire all of the Offered Shares, the Participant may,
within the 30-day period following the expiration of the option granted to the Company under
subsection (b) above, transfer the Offered Shares (other than the Purchased Shares) to the proposed
transferee, provided that such transfer shall not be on terms and conditions more
favorable to the transferee than those contained in the Transfer Notice. Notwithstanding any of
the above, all Offered Shares transferred to a third party pursuant to this Section 4 shall remain
subject to the right of first refusal and transfer restrictions set forth in this Section 4 and
such transferee shall, as a condition to such transfer, deliver to the Company a written instrument
confirming that such transferee shall be bound by all of the terms and conditions of this Section
4.

     (d) After the time at which the Purchased Shares are required to be delivered to the Company
for transfer to the Company pursuant to subsection (b) above, the Company shall not pay any
dividend to the Participant on account of such Purchased Shares or permit the Participant to
exercise any of the privileges or rights of a stockholder with respect to such Purchased Shares,
but shall, in so far as permitted by law, treat the Company as the owner of such Purchased Shares.

     (e) The following transactions shall be exempt from the provisions of this Section 4:

          (1) any transfer of Shares to or for the benefit of any spouse, child or grandchild of the
Participant, or to a trust for their benefit;

          (2) any transfer pursuant to an effective registration statement filed by the Company under
the Securities Act of 1933, as amended (the “Securities Act”); and

          (3) the sale of all or substantially all of the shares of capital stock of the Company
(including pursuant to a merger or consolidation);

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provided, however, that in the case of a transfer pursuant to clause (1) above,
such Shares shall remain subject to the right of first refusal and transfer restrictions set forth
in this Section 4 and such transferee shall, as a condition to such transfer, deliver to the
Company a written instrument confirming that such transferee shall be bound by all of the terms and
conditions of this Section 4.

     (f) The Company may assign its rights to purchase Offered Shares in any particular transaction
under this Section 4 to one or more persons or entities.

     (g) The provisions of this Section 4 shall terminate upon the earlier of the following events:

          (1) the closing of the sale of shares of Common Stock in an underwritten public offering
pursuant to an effective registration statement filed by the Company under the Securities Act; or

          (2) the sale of all or substantially all of the capital stock (other than the sale of capital
stock to one or more venture capitalists or other institutional investors pursuant to an equity
financing (including a debt financing that is convertible into equity) of the Company approved by a
majority of the Board of Directors of the Company), assets or business of the Company, by merger,
consolidation, sale of assets or otherwise (other than a merger or consolidation in which all or
substantially all of the individuals and entities who were beneficial owners of the Common Stock
immediately prior to such transaction beneficially own, directly or indirectly, more than 50% of
the outstanding securities entitled to vote generally in the election of directors of the
resulting, surviving or acquiring corporation in such transaction). A transaction of the type
contemplated by this Section 4(g)(2) is herein referred to as a “Sale” of the Company.

     (h) The Participant shall not transfer any Shares, or any interest therein, to any person or
entity that is a competitor of the Company, as determined by the Board of Directors of the Company
in its sole discretion, unless such transfer is made in connection with the sale of all or
substantially all of the capital stock, assets or business of the Company, by merger,
consolidation, sale of assets or otherwise.

     (i) The Company shall not be required (a) to transfer on its books any of the Shares which
shall have been sold or transferred in violation of any of the provisions set forth in this Section
4, or (b) to treat as owner of such Shares or to pay dividends to any transferee to whom any such
Shares shall have been so sold or transferred.

     (j) The certificate representing Shares shall bear a legend substantially in the following
form (in addition to, or in combination with, any legend required by applicable federal and state
securities laws and agreements relating to the transfer of the Company securities):

     “The shares represented by this certificate are subject to a right of first refusal in favor of the
Company, as provided in a certain stock option agreement with the Company.”

5. Agreement in Connection with Public Offering.

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     The Participant agrees, in connection with the initial underwritten public offering of the
Company’s securities pursuant to a registration statement under the Securities Act, (i) not to
sell, make short sale of, loan, grant any options for the purchase of, or otherwise dispose of any
shares of Common Stock held by the Participant (other than those shares included in the offering)
without the prior written consent of the Company or the underwriters managing such initial
underwritten public offering of the Company’s securities for a period of 180 days from the
effective date of such registration statement, and (ii) to execute any agreement reflecting clause
(i) above as may be requested by the Company or the managing underwriters at the time of such
offering.

6. Withholding.

     No Shares will be issued pursuant to the exercise of this option unless and until the
Participant pays to the Company, or makes provision satisfactory to the Company for payment of, any
federal, state or local withholding taxes required by law to be withheld in respect of this option.

7. Nontransferability of Option.

     This option may not be sold, assigned, transferred, pledged or otherwise encumbered by the
Participant, either voluntarily or by operation of law, except by will or the laws of descent and
distribution, and, during the lifetime of the Participant, this option shall be exercisable only by
the Participant.

8. Disqualifying Disposition.

     If the Participant disposes of Shares acquired upon exercise of this option within two years
from the Grant Date or one year after such Shares were acquired pursuant to exercise of this
option, the Participant shall notify the Company in writing of such disposition.

9. Provisions of the Plan.

     This option is subject to the provisions of the Plan, a copy of which is furnished to the
Participant with this option.

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     IN WITNESS WHEREOF, the Company has caused this option to be executed under its corporate seal
by its duly authorized officer. This option shall take effect as a sealed instrument.

	 	 	 	 	 	 	 
	 	 	Adnexus Therapeutics, Inc.
	 
	 	 	 	 	 	 
	Dated:                                        

	 	By:	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	Name:	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Title:	 	 
	 

	 	 	 	 	 	 

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PARTICIPANT’S ACCEPTANCE

     The undersigned hereby accepts the foregoing option and agrees to the terms and conditions
thereof. The undersigned hereby acknowledges receipt of a copy of the Company’s 2002 Stock
Incentive Plan.

	 	 	 	 	 	 	 
	 	 	PARTICIPANT:	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	Address:	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	 

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Exhibit A

NOTICE OF STOCK OPTION EXERCISE

Date:                    1

Adnexus Therapeutics, Inc.

100 Beaver Street

Waltham, MA 02451

Attention: Treasurer

Dear Sir or Madam:

     I am the holder of                     2 Stock Option granted to me under the Adnexus
Therapeutics, Inc. (the “Company”) 2002 Stock Incentive Plan on                     3 for the
purchase of
                    4 shares of Common Stock of the Company at a purchase price of
$                    5 per share.

     I
hereby exercise my option to purchase
                    6 shares of Common Stock (the
“Shares”), for which I have enclosed                     7 in the amount of                     8.
Please register my stock certificate as follows:

	 	 	 	 	 
	Name(s):

	 	 	 	9
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	Address:
	 	 	 	 
	 

	 	 	 	 

 

			
	1	 	Enter the date of exercise.
	 
	2	 	Enter either “an Incentive” or
“a Nonstatutory”.
	 
	3	 	Enter the date of grant.
	 
	4	 	Enter the total number of shares of Common
Stock for which the option was granted.
	 
	5	 	Enter the option exercise price per share of
Common Stock.
	 
	6	 	Enter the number of shares of Common Stock to
be purchased upon exercise of all or part of the option.
	 
	7	 	Enter “cash”, “personal
check” or if permitted by the option or Plan, “stock certificates
No. XXXX and XXXX”.
	 
	8	 	Enter the dollar amount (price per share of
Common Stock times the number of shares of Common Stock to be purchased), or
the number of shares tendered. Fair market value of shares tendered, together
with cash or check, must cover the purchase price of the shares issued upon
exercise.
	 
	9	 	Enter name(s) to appear on stock certificate:
(a) Your name only; (b) Your name and other name (i.e., John Doe and Jane Doe,
Joint Tenants With Right of Survivorship); or (c) In the case of a Nonstatutory
option only, a Child’s name, with you as custodian (i.e., Jane Doe,
Custodian for Tommy Doe). Note: There may be income and/or gift tax
consequences of registering shares in a Child’s name.

 

 

     Tax I.D. #:    
                   
                   
               
    10

I represent, warrant and covenant as follows:

10. I am purchasing the Shares for my own account for investment only, and not with a view to, or
for sale in connection with, any distribution of the Shares in violation of the Securities Act of
1933 (the “Securities Act”), or any rule or regulation under the Securities Act.

11. I have had such opportunity as I have deemed adequate to obtain from representatives of the
Company such information as is necessary to permit me to evaluate the merits and risks of my
investment in the Company.

12. I have sufficient experience in business, financial and investment matters to be able to
evaluate the risks involved in the purchase of the Shares and to make an informed investment
decision with respect to such purchase.

13. I can afford a complete loss of the value of the Shares and am able to bear the economic risk
of holding such Shares for an indefinite period.

14. I understand that (i) the Shares have not been registered under the Securities Act and are
“restricted securities” within the meaning of Rule 144 under the Securities Act, (ii) the Shares
cannot be sold, transferred or otherwise disposed of unless they are subsequently registered under
the Securities Act or an exemption from registration is then available; (iii) in any event, the
exemption from registration under Rule 144 will not be available for at least one year and even
then will not be available unless a public market then exists for the Common Stock, adequate
information concerning the Company is then available to the public, and other terms and conditions
of Rule 144 are complied with; and (iv) there is now no registration statement on file with the
Securities and Exchange Commission with respect to any stock of the Company and the Company has no
obligation or current intention to register the Shares under the Securities Act.

Very truly yours,

      
                
                 
                
     

(Signature)

 

			
	10	 	Social Security Number of Holder(s).exv10w16

 

Exhibit 10.16

ADNEXUS THERAPEUTICS, INC.

Nonstatutory Stock Option Agreement

Granted Under 2002 Stock Incentive Plan

1. Grant of Option.

     This agreement evidences the grant by Adnexus Therapeutics, Inc., a Delaware corporation (the
“Company”), on                     , 200[ ] (the “Grant Date”) to [                    ], an employee, consultant or
director of the Company (the “Participant”), of an option to purchase, in whole or in part, on the
terms provided herein and in the Company’s 2002 Stock Incentive Plan (the “Plan”), a total of [                    
] shares (the “Shares”) of common stock, $.001 par value per share, of the
Company (“Common Stock”) at $[                    ] per Share. Unless earlier terminated, this option
shall expire on [                    ] (the “Final Exercise Date”) [ten years from date of grant].

     It is intended that the option evidenced by this agreement shall not be an incentive stock
option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any
regulations promulgated thereunder (the “Code”). Except as otherwise indicated by the context, the
term “Participant”, as used in this option, shall be deemed to include any person who acquires the
right to exercise this option validly under its terms.

2. Vesting Schedule.

     This option will become exercisable (“vest”) as to 25% of the original number of Shares on the
first anniversary of the Vesting Commencement Date (as defined below) and as to an additional
6.25%of the original number of Shares at the end of each successive three-month period following
the first anniversary of the Vesting Commencement Date until the fourth anniversary of the Vesting
Commencement Date. For purposes of this Agreement, the “Vesting Commencement Date” shall mean
                    , 200_.

     The right of exercise shall be cumulative so that to the extent the option is not exercised in
any period to the maximum extent permissible it shall continue to be exercisable, in whole or in
part, with respect to all shares for which it is vested until the earlier of the Final Exercise
Date or the termination of this option under Section 3 hereof or the Plan.

3. Exercise of Option.

     (a) Form of Exercise. Each election to exercise this option shall be accompanied by a
completed Notice of Stock Option Exercise in the form attached hereto as Exhibit A, signed
by the Participant, and received by the Company at its principal office, accompanied by this
agreement, and payment in full in the manner provided in the Plan. The Participant may purchase
less than the number of shares covered hereby, provided that no partial exercise of this option may
be for any fractional share or for fewer than ten whole shares.

     (b) Continuous Relationship with the Company Required. Except as otherwise provided
in this Section 3, this option may not be exercised unless the Participant, at the time he or she
exercises this option, is, and has been at all times since the Grant Date, an employee,

 

 

officer or director of, or consultant or advisor to, the Company or any parent or subsidiary
of the Company as defined in Section 424(e) or (f) of the Code (an “Eligible Participant”).

     (c) Termination of Relationship with the Company. If the Participant ceases to be an
Eligible Participant for any reason, then, except as provided in paragraphs (d) and (e) below, the
right to exercise this option shall terminate three months after such cessation (but in no event
after the Final Exercise Date), provided that this option shall be exercisable only
to the extent that the Participant was entitled to exercise this option on the date of such
cessation. Notwithstanding the foregoing, if the Participant, prior to the Final Exercise Date,
violates the non-competition or confidentiality provisions of any employment contract,
confidentiality and nondisclosure agreement or other agreement between the Participant and the
Company, the right to exercise this option shall terminate immediately upon such violation.

     (d) Exercise Period Upon Death or Disability. If the Participant dies or becomes
disabled (within the meaning of Section 22(e)(3) of the Code) prior to the Final Exercise Date
while he or she is an Eligible Participant and the Company has not terminated such relationship for
“cause” as specified in paragraph (e) below, this option shall be exercisable, within the period of
one year following the date of death or disability of the Participant, by the Participant (or in
the case of death by an authorized transferee), provided that this option shall be
exercisable only to the extent that this option was exercisable by the Participant on the date of
his or her death or disability, and further provided that this option shall not be exercisable
after the Final Exercise Date.

     (e) Discharge for Cause. If the Participant, prior to the Final Exercise Date, is
discharged by the Company for “cause” (as defined below), the right to exercise this option shall
terminate immediately upon the effective date of such discharge. “Cause” shall mean willful
misconduct by the Participant or willful failure by the Participant to perform his or her
responsibilities to the Company (including, without limitation, breach by the Participant of any
provision of any employment, consulting, advisory, nondisclosure, non-competition or other similar
agreement between the Participant and the Company), as determined by the Company, which
determination shall be conclusive. The Participant shall be considered to have been discharged for
“Cause” if the Company determines, within 30 days after the Participant’s resignation, that
discharge for cause was warranted.

4. Right of First Refusal and Restrictions on Transfer.

     (a) If the Participant proposes to sell, assign, transfer, pledge, hypothecate or otherwise
dispose of, by operation of law or otherwise (collectively, “transfer”) any Shares acquired upon
exercise of this option, then the Participant shall first give written notice of the proposed
transfer (the “Transfer Notice”) to the Company. The Transfer Notice shall name the proposed
transferee and state the number of such Shares the Participant proposes to transfer (the “Offered
Shares”), the price per share and all other material terms and conditions of the transfer.

     (b) For 60 days following its receipt of such Transfer Notice, the Company shall have the
option to purchase some or all of the Offered Shares at the price and upon the terms set forth in
the Transfer Notice. In the event the Company elects to purchase any Offered Shares (the Offered
Shares to be purchased by the Company hereunder are referred to as the “Purchased

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Shares”), it shall give written notice of such election to the Participant within such 60-day
period. Within 10 days after his receipt of such notice, the Participant shall tender to the
Company at its principal offices the certificate or certificates representing the Purchased Shares,
duly endorsed in blank by the Participant or with duly endorsed stock powers attached thereto, all
in a form suitable for transfer of the Purchased Shares to the Company. Promptly following receipt
of such certificate or certificates, the Company shall deliver or mail to the Participant a check
in payment of the purchase price for the Purchased Shares; provided that if the
terms of payment set forth in the Transfer Notice were other than cash against delivery, the
Company may pay for the Purchased Shares on the same terms and conditions as were set forth in the
Transfer Notice; and provided further that any delay in making such payment shall
not invalidate the Company’s exercise of its option to purchase the Purchased Shares.

     (c) If the Company does not elect to acquire all of the Offered Shares, the Participant may,
within the 30-day period following the expiration of the option granted to the Company under
subsection (b) above, transfer the Offered Shares (other than the Purchased Shares) to the proposed
transferee, provided that such transfer shall not be on terms and conditions more
favorable to the transferee than those contained in the Transfer Notice. Notwithstanding any of
the above, all Offered Shares transferred to a third party pursuant to this Section 4 shall remain
subject to the right of first refusal and transfer restrictions set forth in this Section 4 and
such transferee shall, as a condition to such transfer, deliver to the Company a written instrument
confirming that such transferee shall be bound by all of the terms and conditions of this Section
4.

     (d) After the time at which the Purchased Shares are required to be delivered to the Company
for transfer to the Company pursuant to subsection (b) above, the Company shall not pay any
dividend to the Participant on account of such Purchased Shares or permit the Participant to
exercise any of the privileges or rights of a stockholder with respect to such Purchased Shares,
but shall, in so far as permitted by law, treat the Company as the owner of such Purchased Shares.

     (e) The following transactions shall be exempt from the provisions of this Section 4:

          (1) any transfer of Shares to or for the benefit of any spouse, child or grandchild of the
Participant, or to a trust for their benefit;

          (2) any transfer pursuant to an effective registration statement filed by the Company under
the Securities Act of 1933, as amended (the “Securities Act”); and

          (3) the sale of all or substantially all of the shares of capital stock of the Company
(including pursuant to a merger or consolidation);

provided, however, that in the case of a transfer pursuant to clause (1) above,
such Shares shall remain subject to the right of first refusal and transfer restrictions set forth
in this Section 4 and such transferee shall, as a condition to such transfer, deliver to the
Company a written instrument confirming that such transferee shall be bound by all of the terms and
conditions of this Section 4.

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     (f) The Company may assign its rights to purchase Offered Shares in any particular transaction
under this Section 4 to one or more persons or entities.

     (g) The provisions of this Section 4 shall terminate upon the earlier of the following events:

          (1) the closing of the sale of shares of Common Stock in an underwritten public offering
pursuant to an effective registration statement filed by the Company under the Securities Act; or

          (2) the sale of all or substantially all of the capital stock (other than the sale of capital
stock to one or more venture capitalists or other institutional investors pursuant to an equity
financing (including a debt financing that is convertible into equity) of the Company approved by a
majority of the Board of Directors of the Company), assets or business of the Company, by merger,
consolidation, sale of assets or otherwise (other than a merger or consolidation in which all or
substantially all of the individuals and entities who were beneficial owners of the Common Stock
immediately prior to such transaction beneficially own, directly or indirectly, more than 50% of
the outstanding securities entitled to vote generally in the election of directors of the
resulting, surviving or acquiring corporation in such transaction).

     (h) The Participant shall not transfer any Shares, or any interest therein, to any person or
entity that is a competitor of the Company, as determined by the Board of Directors of the Company
in its sole discretion, unless such transfer is made in connection with the sale of all or
substantially all of the capital stock, assets or business of the Company, by merger,
consolidation, sale of assets or otherwise.

     (i) The Company shall not be required (a) to transfer on its books any of the Shares which
shall have been sold or transferred in violation of any of the provisions set forth in this Section
4, or (b) to treat as owner of such Shares or to pay dividends to any transferee to whom any such
Shares shall have been so sold or transferred.

     (j) The certificate representing Shares shall bear a legend substantially in the following
form (in addition to, or in combination with, any legend required by applicable federal and state
securities laws and agreements relating to the transfer of the Company securities):

“The shares represented by this certificate are subject to a right of first refusal in favor of the
Company, as provided in a certain stock option agreement with the Company.”

5. Agreement in Connection with Public Offering.

     The Participant agrees, in connection with the initial underwritten public offering of the
Company’s securities pursuant to a registration statement under the Securities Act, (i) not to
sell, make short sale of, loan, grant any options for the purchase of, or otherwise dispose of any
shares of Common Stock held by the Participant (other than those shares included in the offering)
without the prior written consent of the Company or the underwriters managing such initial
underwritten public offering of the Company’s securities for a period of 180 days from the
effective date of such registration statement, and (ii) to execute any agreement reflecting clause

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(i) above as may be requested by the Company or the managing underwriters at the time of such
offering.

6. Withholding.

     No Shares will be issued pursuant to the exercise of this option unless and until the
Participant pays to the Company, or makes provision satisfactory to the Company for payment of, any
federal, state or local withholding taxes required by law to be withheld in respect of this option.

7. Nontransferability of Option.

     This option may not be sold, assigned, transferred, pledged or otherwise encumbered by the
Participant, either voluntarily or by operation of law, except by will or the laws of descent and
distribution, and, during the lifetime of the Participant, this option shall be exercisable only by
the Participant.

8. Provisions of the Plan.

     This option is subject to the provisions of the Plan, a copy of which is furnished to the
Participant with this option.

     IN WITNESS WHEREOF, the Company has caused this option to be executed under its corporate seal
by its duly authorized officer. This option shall take effect as a sealed instrument.

	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	ADNEXUS THERAPEUTICS, INC.
	 
	 	 	 	 	 	 	 	 	 	 
	Dated:

	 	 	 	 	 	By:	 	 	 	 
	 

	 	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	Name:	 	 
	 

	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	Title:	 	 
	 

	 	 	 	 	 	 	 	 	 	 

- 5 -

 

PARTICIPANT’S ACCEPTANCE

     The undersigned hereby accepts the foregoing option and agrees to the terms and conditions
thereof. The undersigned hereby acknowledges receipt of a copy of the Company’s 2002 Stock
Incentive Plan.

	 	 	 	 	 	 	 
	 	 	PARTICIPANT:	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	Address:	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	 

- 6 -

 

Exhibit A

NOTICE OF STOCK OPTION EXERCISE

Date:                    1

Adnexus Therapeutics, Inc.

100 Beaver Street

Waltham, MA 02451

Attention: Treasurer

Dear Sir or Madam:

     I am the holder of                     2 Stock Option granted to me under the Adnexus
Therapeutics, Inc. (the “Company”) 2002 Stock Incentive Plan on                     3 for the
purchase
of                    4 shares of Common Stock of the Company at a purchase price of
$                    5 per share.

     I
hereby exercise my option to purchase                     6 shares of Common Stock (the
“Shares”), for which I have enclosed                     7 in the amount of                     8.
Please register my stock certificate as follows:

	 	 	 	 	 
	Name(s):

	 	 	 	9
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	Address:
	 	 	 	 
	 

	 	 	 	 

 

			
	1	 	Enter the date of exercise.
	 
	2	 	Enter either “an Incentive” or
“ a Nonstatutory”.
	 
	3	 	Enter the date of grant.
	 
	4	 	Enter the total number of shares of Common
Stock for which the option was granted.
	 
	5	 	Enter the option exercise price per share of
Common Stock.
	 
	6	 	Enter the number of shares of Common Stock to
be purchased upon exercise of all or part of the option.
	 
	7	 	Enter “cash”, “personal
check” or if permitted by the option or Plan, “stock certificates
No. XXXX and XXXX”.
	 
	8	 	Enter the dollar amount (price per share of
Common Stock times the number of shares of Common Stock to be purchased), or
the number of shares tendered. Fair market value of shares tendered, together
with cash or check, must cover the purchase price of the shares issued upon
exercise.
	 
	9	 	Enter name(s) to appear on stock certificate:
(a) Your name only; (b) Your name and other name (i.e., John Doe and Jane Doe,
Joint Tenants With Right of Survivorship); or (c) In the case of a Nonstatutory
option only, a Child’s name, with you as custodian (i.e., Jane Doe,
Custodian for Tommy Doe). Note: There may be income and/or gift tax
consequences of registering shares in a Child’s name.

 

 

     Tax I.D. #:                     10

     I represent, warrant and covenant as follows:

9. I am purchasing the Shares for my own account for investment only, and not with a view to, or
for sale in connection with, any distribution of the Shares in violation of the Securities Act of
1933 (the “Securities Act”), or any rule or regulation under the Securities Act.

10. I have had such opportunity as I have deemed adequate to obtain from representatives of the
Company such information as is necessary to permit me to evaluate the merits and risks of my
investment in the Company.

11. I have sufficient experience in business, financial and investment matters to be able to
evaluate the risks involved in the purchase of the Shares and to make an informed investment
decision with respect to such purchase.

12. I can afford a complete loss of the value of the Shares and am able to bear the economic risk
of holding such Shares for an indefinite period.

13. I understand that (i) the Shares have not been registered under the Securities Act and are
“restricted securities” within the meaning of Rule 144 under the Securities Act, (ii) the Shares
cannot be sold, transferred or otherwise disposed of unless they are subsequently registered under
the Securities Act or an exemption from registration is then available; (iii) in any event, the
exemption from registration under Rule 144 will not be available for at least one year and even
then will not be available unless a public market then exists for the Common Stock, adequate
information concerning the Company is then available to the public, and other terms and conditions
of Rule 144 are complied with; and (iv) there is now no registration statement on file with the
Securities and Exchange Commission with respect to any stock of the Company and the Company has no
obligation or current intention to register the Shares under the Securities Act.

Very truly yours,

	 	 	 
	 

(Signature)

	 	 

 

			
	10	 	Social Security Number of Holder(s).

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