Document:

Securities Purchase Agreement

 EXHIBIT 10.1 
 SECURITIES PURCHASE AGREEMENT 
 SECURITIES PURCHASE AGREEMENT (the
“Agreement”), dated as of March 20, 2006, by and among CardioVascular BioTherapeutics, Inc., a Delaware corporation, with headquarters currently located at 7251 West Lake Mead Boulevard, Suite 303, Las Vegas, Nevada 89128, to
be relocated to 1635 Village Center Circle, Suite 250, Las Vegas, Nevada 89134, effective April 1, 2006 (the “Company”), and the investors listed on the Schedule of Buyers attached hereto (individually, a
“Buyer” and collectively, the “Buyers”). 
 WHEREAS: 
 A. The Company and the Buyers are executing and delivering this Agreement in reliance upon the exemption from securities registration afforded by
Rule 506 of Regulation D (“Regulation D”) as promulgated by the United States Securities and Exchange Commission (the “SEC”) under the Securities Act of 1933, as amended (the “1933
Act”); 
 B. The Buyers, severally, and not jointly, wish to purchase from the Company and the Company wishes to sell to the Buyers,
upon the terms and conditions stated in this Agreement (I) senior secured notes, substantially in the form attached as Exhibit A, in an original aggregate principal amount of $20,000,000 (such notes, together with any promissory
notes or other securities issued in exchange or substitution therefor or replacement thereof, and as any of the same may be amended, restated or modified and in effect from time to time, the “Notes”), and (II) warrants,
substantially in the form attached as Exhibit B, to acquire that number of shares of the Company’s common stock, par value $0.001 per share (the “Common Stock”) equal to the quotient of (a) 30% of the original
principal amount of the Notes purchased by the Buyers at the Closing (as defined in Section 1(a)), divided by (b) the Warrant Exercise Price (as defined in the Initial Warrants (as defined below)) as of the Closing Date (as defined in
Section 1(b)) (such warrants, together with any warrants or other securities issued in exchange or substitution therefor or replacement thereof, and as any of the same may be amended, restated or modified and in effect from time to time, being
referred to as the “Initial Warrants”; the shares of Common Stock issuable upon exercise of the Initial Warrants being referred to as the “Initial Warrant Shares”); 
 C. The Notes shall be convertible into shares of Common Stock (the shares of Common Stock issuable upon conversion of the Notes being referred to herein
as the “Conversion Shares”) in accordance with the terms of the Notes; 
 D. Pursuant to the Notes, and subject to the terms
and conditions thereof, the Company may be required to issue to the Buyers Repurchase Warrants (as defined in the Notes), substantially in the form attached as Exhibit C, to acquire shares of Common Stock (such warrants, together with
any warrants or other securities issued in exchange or substitution therefor or replacement thereof and as any of the same may be amended, restated, modified or supplemented and in effect from time to time, being collectively referred to herein as
the “Repurchase Warrants” and, collectively with the Initial Warrants, the “Warrants”; and the shares of Common Stock issuable upon exercise of the Repurchase Warrants being referred to 

 
herein as the “Repurchase Warrant Shares” and, collectively with the Initial Warrants, the “Warrant Shares”). 

E. Contemporaneously with the execution and delivery of this Agreement, the parties hereto are executing and delivering a Registration Rights
Agreement, substantially in the form attached as Exhibit D (the “Registration Rights Agreement”), pursuant to which the Company has agreed to provide certain registration rights under the 1933 Act and the rules and
regulations promulgated thereunder, and applicable state securities laws; 
 F. Contemporaneously with the Closing, the parties hereto will
execute and deliver a Security Agreement, substantially in the form attached as Exhibit E (the “Security Agreement”), and a Patent Security Agreement, substantially in the form attached as Exhibit F (the
“Patent Security Agreement”), pursuant to which the Company will agree to provide the Buyers with a security interest in all of the assets of the Company, including all patents and patent rights; 
 G. Contemporaneously with the Closing, the parties hereto will execute and deliver one or more Deposit Account Control Agreements, substantially in the
form attached as Exhibit G (the “Account Control Agreements”), pursuant to which the Company will agree to enable the Buyers to perfect their security interest in all of the Company’s right, title and interest in
certain accounts and in all collateral from time to time credited to such accounts; 
 H. Contemporaneously with the Closing, Daniel C.
Montano (“Montano”) will execute and deliver a Guaranty, substantially in the form attached as Exhibit H (the “Montano Guaranty”), pursuant to which Montano will agree to guaranty certain obligations of
the Company; and 
 I. Contemporaneously with the Closing, the parties hereto will execute and deliver a Pledge Agreement, substantially in
the form attached as Exhibit I (the “Pledge Agreement”), pursuant to which the Company will agree to pledge all of the capital stock of the Subsidiaries (as defined in Section 3(a)) owned by the Company to the
Buyers as collateral for the Notes. 
 NOW THEREFORE, the Company and the Buyers hereby agree as follows: 
 1. PURCHASE AND SALE OF NOTES AND WARRANTS. 
 a. Purchase of Notes and Warrants. Subject to the satisfaction (or waiver) of the conditions set forth in Sections 6(a) and 7(a) below, on the Closing Date (as defined in Section 1(b)), the Company
shall issue and sell to each Buyer, and each Buyer severally agrees to purchase from the Company, (i) Notes in the principal amount set forth opposite such Buyer’s name on the Schedule of Buyers, along with (ii) the related
Initial Warrants with respect to the number of Warrant Shares equal to the quotient (rounded to the nearest whole number, with 0.5 rounded up) of (A) 30% of the original principal amount of the Notes purchased by such Buyer at the Closing,
divided by (B) the Warrant Exercise Price (as defined in the Initial Warrants) (the “Closing”). The purchase price (the “Purchase Price”) of the Notes and the related Warrants at the Closing shall be equal to
$1.00 for each $1.00 of principal amount of the Notes purchased 

  

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(representing an aggregate Purchase Price of $20,000,000 for the aggregate original principal amount of $20,000,000 of Notes and the related Warrants to be
purchased at the Closing). 
 b. The Closing Date. The date and time of the Closing (the “Closing
Date”) shall be 10:00 a.m., New York City time, on the first day other than Saturday, Sunday or other day on which commercial banks in the City of New York are authorized or required by law to remain closed (a “Business
Day”) following the date of this Agreement, subject to the satisfaction (or waiver) of all of the conditions to the Closing set forth in Sections 6(a) and 7(a) (or such later or earlier date as is mutually agreed to by the Company and
the Buyers). The Closing shall occur on the Closing Date at the offices of Katten Muchin Rosenman LLP, 525 West Monroe Street, Chicago, Illinois 60661-3693 or at such other time, date and place as the Company and the Buyers may collectively
designate in writing. 
 c. Form of Payment. On the Closing Date, (i) each Buyer shall pay the applicable Purchase
Price to the Company for the Notes and the Initial Warrants to be issued and sold to such Buyer on the Closing Date, by wire transfer of immediately available funds in accordance with the Company’s written wire instructions, less any amount
withheld pursuant to Section 4(h), and (ii) the Company shall deliver to each Buyer, Notes (in the principal amounts as such Buyer shall request) (the “Note Certificates”) representing such principal amount of the Notes
that such Buyer is purchasing hereunder at the Closing, along with warrants representing the Initial Warrants that such Buyer is purchasing hereunder at the Closing, duly executed on behalf of the Company and registered in the name of such Buyer or
its designee. 
 2. BUYER’S REPRESENTATIONS AND WARRANTIES. 
 Each Buyer represents and warrants, as of the date of this Agreement and the Closing Date, with respect to only itself, that: 
 a. Investment Purpose. Such Buyer (i) is acquiring the Notes and the Initial Warrants purchased by such Buyer hereunder,
(ii) upon any conversion of the Notes, will acquire the Conversion Shares then issuable, (iii) will acquire any Repurchase Warrants issued to such Buyer pursuant to any Note and (iv) upon any exercise of any Warrants issued to such
Buyer will acquire the Warrant Shares issuable upon such exercise thereof (the Notes, the Conversion Shares, the Warrants and the Warrant Shares being collectively referred to herein as the “Securities”) for its own account and not
with a view towards, or for resale in connection with, the public sale or distribution thereof, except pursuant to sales registered or exempted under the 1933 Act; provided, however, that by making the representations herein, such Buyer does not
agree to hold any of the Securities for any minimum or other specific term and reserves the right to dispose of the Securities at any time in accordance with or pursuant to a registration statement or an exemption under the 1933 Act.

 b. Accredited Investor Status. Such Buyer is an “accredited investor” as that term is defined in
Rule 501(a) of Regulation D. 
 c. Reliance on Exemptions. Such Buyer understands that the Securities are
being offered and sold to it in reliance on specific exemptions from the registration requirements 

  

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of the United States federal and state securities laws and that the Company is relying in part upon the truth and accuracy of, and such Buyer’s
compliance with, the representations, warranties, agreements, acknowledgments and understandings of such Buyer set forth herein in order to determine the availability of such exemptions and the eligibility of such Buyer to acquire the Securities.

 d. Information. Such Buyer and its advisors, if any, have been furnished with all materials relating to the
business, finances and operations of the Company and materials relating to the offer and sale of the Securities that have been requested by such Buyer. Such Buyer and its advisors, if any, have been afforded the opportunity to ask questions of the
Company. Neither such inquiries nor any other due diligence investigations conducted by such Buyer or its advisors, if any, or its representatives shall modify, amend or affect such Buyer’s right to rely on the Company’s representations
and warranties contained in Sections 3 and 9(l) below. Such Buyer understands that its investment in the Securities involves a high degree of risk. Such Buyer has sought such accounting, legal and tax advice as it has considered necessary to
make an informed investment decision with respect to its acquisition of the Securities. 
 e. No Governmental Review.
Such Buyer understands that no United States federal or state agency or any other government or governmental agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability of the investment in the
Securities nor have such authorities passed upon or endorsed the merits of the offering of the Securities. 
 f. Transfer
or Resale. Such Buyer understands that, except as provided in the Registration Rights Agreement, (i) the Securities have not been and are not being registered under the 1933 Act or any state securities laws, and may not be offered for sale,
sold, assigned or transferred unless (A) subsequently registered thereunder, (B) such Buyer shall have delivered to the Company an opinion of counsel, in a generally acceptable form, to the effect that such Securities to be sold, assigned
or transferred may be sold, assigned or transferred pursuant to an exemption from such registration, or (C) such Buyer provides the Company with reasonable assurance that such Securities can be sold, assigned or transferred pursuant to
Rule 144 promulgated under the 1933 Act (or a successor rule thereto) (“Rule 144”); (ii) any sale of the Securities made in reliance on Rule 144 may be made only in accordance with the terms of Rule 144, and
further, if Rule 144 is not applicable, any resale of the Securities under circumstances in which the seller (or the Person (as defined in the Notes) through whom the sale is made) may be deemed to be an underwriter (as that term is defined in
the 1933 Act) may require compliance with some other exemption under the 1933 Act or the rules and regulations of the SEC thereunder; and (iii) neither the Company nor any other Person is under any obligation to register the
Securities under the 1933 Act or any state securities laws or to comply with the terms and conditions of any exemption thereunder. Notwithstanding the foregoing, the Securities may be pledged in connection with a bona fide margin account or
other loan or financing arrangement secured by the Securities. 
 g. Legends. Such Buyer understands that the
certificates or other instruments representing the Notes and the Warrants and, until such time as the sale of the Conversion Shares and the Warrant Shares have been registered under the 1933 Act as 

  

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contemplated by the Registration Rights Agreement, the stock certificates representing the Conversion Shares and the Warrant Shares, except as set forth
below, shall bear a restrictive legend in substantially the following form (and a stop-transfer order may be placed against transfer of such stock certificates): 
 THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED
OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS OR (B) AN OPINION OF COUNSEL, IN A GENERALLY ACCEPTABLE
FORM, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR APPLICABLE STATE SECURITIES LAWS OR (II) UNLESS SOLD PURSUANT TO RULE 144 UNDER SAID ACT. NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE
MARGIN ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES. 
 The legend set forth above shall be removed and the Company shall issue a
certificate without such legend to the holder of the Securities upon which it is stamped, if (i) such Securities are registered for resale under the 1933 Act, (ii) in connection with a sale transaction, such holder provides the
Company with an opinion of counsel, in a generally acceptable form, to the effect that a public sale, assignment or transfer of the Securities may be made without registration under the 1933 Act, (iii) such holder provides the Company with
reasonable assurances that the Securities can be sold pursuant to Rule 144(k) promulgated under the 1933 Act (or a successor rule thereto), or (iv) such holder provides the Company reasonable assurance that the Securities have been or
are being sold pursuant to Rule 144. 
 h. Authorization; Enforcement; Validity. Such Buyer is a validly existing
corporation, partnership, limited liability company or other entity and has the requisite corporate, partnership, limited liability or other organizational power and authority to purchase the Securities pursuant to this Agreement. This Agreement and
the Registration Rights Agreement have been duly and validly authorized, executed and delivered on behalf of such Buyer and are valid and binding agreements of such Buyer enforceable against such Buyer in accordance with their respective terms. The
Security Agreement, the Patent Security Agreement, the Account Control Agreements and each of the other agreements entered into and other documents executed by such Buyer in connection with the transactions contemplated hereby and thereby as of the
Closing will have been duly and validly authorized, executed and delivered on behalf of such Buyer as of the Closing and will be valid and binding agreements of such Buyer enforceable against such Buyer in accordance with their respective terms.

 i. Residency. Such Buyer is a resident of that jurisdiction specified below its address on the Schedule of
Buyers. 
  

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 3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY. 
 The Company represents and warrants, as of the date of this Agreement and the Closing Date, to each of the Buyers, that: 
 a. Organization and Qualification. Set forth in Schedule 3(a) is a true and correct list of the entities in which the
Company, directly or indirectly, owns capital stock or holds an equity or similar interest. Each of the Company and its Subsidiaries is a corporation, limited liability company, partnership or other entity and is duly organized and validly existing
in good standing under the laws of the jurisdiction in which it is incorporated and has the requisite corporate, partnership, limited liability company or other organizational power and authority to own its properties and to carry on its business as
now being conducted. The Company is duly qualified to do business and is in good standing in every jurisdiction in which its ownership of property or the nature of the business conducted by it makes such qualification necessary, except to the extent
that the failure to be so qualified or be in good standing would not have a Material Adverse Effect. As used in this Agreement, “Material Adverse Effect” means any material adverse effect on the business, properties, assets,
operations, results of operations, financial condition, credit worthiness or prospects of the Company or on the transactions contemplated hereby or on the agreements and instruments to be entered into in connection herewith, or on the authority or
ability of the Company to perform its obligations under the Transaction Documents (as defined in Section 3(b)). Except as set forth in Schedule 3(a), the Company holds all right, title and interest in and to 100% of the capital
stock, equity or similar interests of each of its Subsidiaries, in each case, free and clear of any Liens (as defined below), including any restriction on the use, voting, transfer, receipt of income or other exercise of any attributes of free and
clear ownership by a current holder, and no such Subsidiary other than Phage Biotechnology Corporation (“Phage”) owns capital stock or holds an equity or similar interest in any other Person. The Company does not have as of the date
of this Agreement, and will not have as of the Closing Date, any Majority-Owned Subsidiaries. “Lien” means, with respect to any asset, any mortgage, lien, pledge, hypothecation, charge, security interest, encumbrance or adverse
claim of any kind and any restrictive covenant, condition, restriction or exception of any kind that has the practical effect of creating a mortgage, lien, pledge, hypothecation, charge, security interest, encumbrance or adverse claim of any
kind (including any of the foregoing created by, arising under or evidenced by any conditional sale or other title retention agreement, the interest of a lessor with respect to a Capital Lease Obligation (as defined in the Notes), or any financing
lease having substantially the same economic effect as any of the foregoing). “Subsidiary” means any entity in which the Company owns any of the outstanding capital stock, equity or similar interests or voting power of such entity
at the time of this Agreement or at any time hereafter, whether directly or through any other Subsidiary. “Majority-Owned Subsidiary” means any Subsidiary of the Company of which the Company owns in excess of 50% of the outstanding
equity interests therein or outstanding voting power thereof at the time of this Agreement or at any time hereafter, whether directly or through any other Subsidiary. “Minority-Owned Subsidiary” means any Subsidiary of the Company
which is not a Majority-Owned Subsidiary. 
 b. Authorization; Enforcement; Validity. The Company has the requisite
corporate power and authority to enter into and perform its obligations under each of this 

  

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Agreement, the Registration Rights Agreement, the Irrevocable Transfer Agent Instructions (as defined in Section 5), the Notes, the Warrants, the
Security Agreement, the Patent Security Agreement, the Account Control Agreements, the Pledge Agreement and each of the other agreements to which it is a party or by which it is bound and which is entered into by the parties hereto in connection
with the transactions contemplated hereby and thereby (collectively, the “Transaction Documents”), and to issue the Securities in accordance with the terms hereof and thereof. The execution and delivery of the Transaction Documents
by the Company and the consummation by the Company of the transactions contemplated hereby and thereby, including the issuance of $20,000,000 in principal amount of the Notes and the related Initial Warrants and any Repurchase Warrants and the
reservation for issuance and the issuance of the Conversion Shares and Warrant Shares issuable upon conversion or exercise thereof, have been duly authorized by the Company’s Board of Directors and no further consent or authorization is
required by the Company, its Board of Directors or its stockholders. This Agreement and the other Transaction Documents dated of even date herewith have been duly executed and delivered by the Company and constitute the valid and binding obligations
of the Company, enforceable against the Company in accordance with their terms. As of the Closing, the Transaction Documents dated after the date of this Agreement and on or prior to the date of the Closing shall have been duly executed and
delivered by the Company and shall constitute the valid and binding obligations of the Company, enforceable against the Company in accordance with their terms. As of the Closing, the Montano Guaranty shall have been duly executed and delivered by
Montano and shall constitute the valid and binding obligation of Montano, enforceable against Montano in accordance with its terms. 
 c. Capitalization. As of the date of this Agreement, the authorized capital stock of the Company consists of (i) 400,000,000 shares of Common Stock, of which as of the date of this Agreement 123,899,598 shares are issued and
outstanding, 5,000,000 shares are reserved for issuance pursuant to the Company’s stock option, restricted stock and stock purchase plans, including 550,500 shares issuable pursuant to outstanding awards under such plans, and 4,156,534 shares
are issuable and reserved for issuance pursuant to securities issued or to be issued (other than the Notes and the Warrants, and other than pursuant to the Company’s stock option, restricted stock and stock purchase plans) exercisable or
exchangeable for, or convertible into, shares of Common Stock, and (ii) 10,000,000 shares of Preferred Stock, $0.001 par value, of which no shares are issued and outstanding. All of such outstanding or issuable shares have been, or upon
issuance will be, validly issued and are, or upon issuance will be, fully paid and nonassessable. Except as disclosed in Schedule 3(c), (A) no shares of the capital stock of the Company are subject to preemptive rights or any other
similar rights or any Liens suffered or permitted by the Company; (B) there are no outstanding options, warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights convertible
into or exercisable for, any shares of capital stock of the Company or any of its Subsidiaries, or contracts, commitments, understandings or arrangements by which the Company or any of its Subsidiaries is or may become bound to issue additional
shares of capital stock of the Company or any of its Subsidiaries, or options, warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights convertible into or exercisable for, any
shares of capital stock of the Company or any of its Subsidiaries; (C) there are no agreements or arrangements under which the Company or any of its Subsidiaries is obligated to register the sale of any of their securities under the
1933 Act (except the Registration 

  

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Rights Agreement); (D) there are no outstanding securities or instruments of the Company or any of its Subsidiaries that contain any redemption or
similar provisions, and there are no contracts, commitments, understandings or arrangements by which the Company or any of its Subsidiaries is or may become bound to redeem a security of the Company; (E) there are no securities or instruments
containing anti-dilution or similar provisions that will or may be triggered by the issuance of the Securities; and (F) the Company does not have any stock appreciation rights or “phantom stock” plans or agreements or any similar plan
or agreement. The Company has furnished to each Buyer true and correct copies of the Company’s Certificate of Incorporation, as amended and as in effect on the date this representation is made (the “Certificate of
Incorporation”), and the Company’s Bylaws, as amended and as in effect on the date this representation is made (the “Bylaws”), and the terms of all securities convertible into, or exercisable or exchangeable for,
Common Stock, and the material rights of the holders thereof in respect thereto. 
 d. Issuance of Securities. The
Notes are duly authorized and, upon issuance in accordance with the terms hereof, shall be (i) free from all taxes and Liens with respect to the issuance thereof and (ii) entitled to the rights set forth in the Notes. At least 10,000,000
shares of Common Stock (subject to adjustment pursuant to the Company’s covenant set forth in Section 4(f) below) have been duly authorized and reserved for issuance upon conversion of the Notes and upon exercise of the Warrants. Upon
conversion or exercise in accordance with the Notes or the Warrants, as the case may be, the Conversion Shares and the Warrant Shares will be validly issued, fully paid and nonassessable and free from all taxes and Liens with respect to the issue
thereof, with the holders being entitled to all rights accorded to a holder of Common Stock. Assuming the accuracy of the representations and warranties of the Buyers set forth in Section 2(a), 2(b), 2(d) and 2(i), the issuance by the Company
of the Securities is exempt from registration under the 1933 Act and applicable state securities laws. 
 e. No
Conflicts. The execution and delivery of the Transaction Documents by the Company, the performance by such parties of their obligations thereunder and the consummation by such parties of the transactions contemplated thereby (including the
reservation for issuance and issuance of the Conversion Shares and the Warrant Shares) will not (i) result in a violation of the Certificate of Incorporation or the Bylaws of the Company; (ii) conflict with, or constitute a breach or
default (or an event which, with the giving of notice or lapse of time or both, constitutes or would constitute a breach or default) under, or give to others any right of termination, amendment, acceleration or cancellation of, or other remedy with
respect to, any agreement, indenture or instrument to which the Company is a party; (iii) result in a violation of any law, rule, regulation, order, judgment or decree (including federal and state securities laws and regulations) applicable to
the Company or by which any property or asset of the Company is bound or affected. The Company is not in violation of any term of its Certificate of Incorporation or Bylaws. The Company is not in violation of any term of or in default under (or with
the giving of notice or lapse of time or both would be in violation of or default under) any contract, agreement, mortgage, indebtedness, indenture, instrument, judgment, decree or order or any statute, rule or regulation applicable to the Company.
The business of the Company is not being conducted, and shall not be conducted, in violation of any law, ordinance or regulation of any governmental entity. Except for the filings and listings contemplated by the Registration Rights Agreement or
described in Section 4(b) and Section 4(g), and the filing of 

  

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instruments to perfect security interests, the Company is not required to obtain any consent, authorization or order of, or make any filing or registration
with, any court or governmental agency or any regulatory or self-regulatory agency in order for it to execute, deliver or perform any of its obligations under or contemplated by the Transaction Documents in accordance with the terms hereof or
thereof. All consents, authorizations, orders, filings and registrations that the Company is required to obtain as described in the preceding sentence have been obtained or effected on or prior to the date of this Agreement. To the Knowledge (as
defined below) of the Company, there are no facts or circumstances that might give rise to any of the foregoing. The Company is in compliance with applicable provision of the Sarbanes-Oxley Act of 2002, as amended, and the rules and regulations
thereunder (collectively, “Sarbanes-Oxley”). The “Knowledge” of the Company means, unless otherwise specified, the actual knowledge of any executive officer of the Company, including Montano, Mickael A. Flaa, and
John William Jacobs, Ph.D., and each of Kenneth A. Thomas, Ph.D. and Thomas J. Stegmann, M.D. 
 f. SEC Documents;
Financial Statements. Since December 31, 2004, the Company has filed all reports, schedules, forms, statements and other documents required to be filed by it with the SEC pursuant to the reporting requirements of the 1934 Act (all of the
foregoing filed prior to the date this representation is made (including all exhibits included therein and financial statements and schedules thereto and documents incorporated by reference therein) being hereinafter referred to as the “SEC
Documents”). A complete and accurate list of the SEC Documents is set forth on Schedule 3(f). The Company has made available to the Buyers or their respective representatives true and complete copies of the SEC Documents. Each
of the SEC Documents was filed with the SEC within the time frames prescribed by the SEC for the filing of such SEC Documents (including any extensions of such time frames permitted by Rule 12b-25 under the 1934 Act) such that each filing was
timely filed (or deemed timely filed pursuant to Rule 12b-25 under the 1934 Act) with the SEC. As of their respective dates, the SEC Documents complied in all material respects with the requirements of the 1934 Act and the rules and
regulations of the SEC promulgated thereunder applicable to the SEC Documents. None of the SEC Documents, at the time they were filed with the SEC, contained any untrue statement of a material fact or omitted to state a material fact required to be
stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. Since the filing of the SEC Documents, no event has occurred that would require an amendment or supplement
to any of the SEC Documents. The Company has not received any written comments from the SEC staff that have not been resolved to the satisfaction of the SEC staff. As of their respective dates, the financial statements of the Company included in the
SEC Documents complied as to form in all material respects with applicable accounting requirements and the published rules and regulations of the SEC with respect thereto. Such financial statements have been prepared in accordance with United States
generally accepted accounting principles (“GAAP”), consistently applied, during the periods involved (except (i) as may be otherwise indicated in such financial statements or the notes thereto, or (ii) in the case of
unaudited interim statements, to the extent they may exclude footnotes or may be condensed or summary statements) and fairly present in all material respects the financial position of the Company as of the dates thereof and the results of their
operations and cash flows for the periods then ended (subject, in the case of unaudited statements, to normal year-end audit adjustments that are not material individually or in the aggregate). None of the Company or any of its officers, directors
or Affiliates (as defined in Section 4(j)) or, to the Company’s Knowledge, any 

  

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stockholder of the Company has made any other filing with the SEC, issued any press release or made any other public statement or communication on behalf of
the Company or otherwise relating to the Company or any of its Subsidiaries that contains any untrue statement of a material fact or omits any statement of material fact necessary in order to make the statements therein, in the light of the
circumstances under which they are or were made, not misleading or has provided any other information to the Buyers, including information referred to in Section 2(d), that contains any untrue statement of a material fact or omits to state any
material fact necessary in order to make the statements therein, in the light of the circumstances under which they are or were made, not misleading. Except as set forth on Schedules 3(f) and 3(w), which will be filed with the Form 8-K
to be filed by the Company pursuant to Section 4(i) hereof, none of the Company or any of its officers, directors, employees or agents has provided the Buyers with any material, nonpublic information. The Company is not required to file and
will not be required to file any agreement, note, lease, mortgage, deed or other instrument entered into prior to the date this representation is made and to which the Company is a party or by which the Company is bound that has not been previously
filed as an exhibit (including by way of incorporation by reference) to its reports filed or made with the SEC under the 1934 Act. The accounting firm of Singer Lewak Greenbaum & Goldstein LLP, which has expressed its opinion with
respect to the consolidated financial statements included in the Company’s annual report on Form 10-K for the fiscal year ended December 31, 2004 (the “Audit Opinion”) and reviewed the consolidated financial standards
included in the Company’s most recently filed quarterly report on Form 10-Q is independent of the Company pursuant to the standards set forth in Rule 2-01 of Regulation S-X promulgated by the SEC, and such firm was otherwise
qualified to render the Audit Opinion and complete such review under applicable law and the rules and regulations of the SEC. There is no transaction, arrangement or other relationship between the Company and an unconsolidated or other
off-balance-sheet entity that is required to be disclosed by the Company in its reports pursuant to the 1934 Act that has not been so disclosed in the SEC Documents. Since September 23, 2004, neither the Company nor, to the Knowledge of
the Company, any director, officer or employee, of the Company, has received or otherwise had or obtained Knowledge of any material complaint, allegation, assertion or claim, whether written or oral, regarding the accounting or auditing practices,
procedures, methodologies or methods of the Company or its internal accounting controls, including any complaint, allegation, assertion or claim that the Company has engaged in questionable accounting or auditing practices. No attorney representing
the Company, whether or not employed by the Company, has reported evidence of a material violation of securities laws, breach of fiduciary duty or similar violation by the Company or any of its officers, directors, employees or agents to the
Company’s board of directors or any committee thereof or to any director or officer of the Company pursuant to Section 307 of the Sarbanes-Oxley Act of 2002, and the SEC’s rules and regulations promulgated thereunder. Since
September 23, 2004, there have been no internal investigations regarding accounting or revenue recognition discussed with, reviewed by or initiated at the direction of the chief executive officer, principal financial officer, the board or any
committee thereof. The Company is eligible to register the Conversion Shares and the Warrant Shares for resale by the Buyer, on Form S-3 promulgated under the 1933 Act. 
 g. Absence of Certain Changes. Except as disclosed in any SEC Documents that were filed with the SEC at least five (5) days
prior to the date of this Agreement, since December 31, 2004, there has been no Material Adverse Effect. The Company has not taken any 

  

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steps, and the Company currently does not expect to take any steps, to seek protection pursuant to any bankruptcy law nor does the Company have any Knowledge
or reason to believe that the creditors of the Company intend to initiate involuntary bankruptcy proceedings or any Knowledge of any fact that would reasonably lead a creditor to do so. The Company is not as of the date this representation is made,
nor after giving effect to the transactions contemplated hereby, will be Insolvent (as defined below). For purposes of this Section 3(g), “Insolvent” means (i) the present fair saleable value of the Company’s assets
is less than the amount required to pay the Company’s total indebtedness, contingent or otherwise, (ii) the Company is unable to pay its debts and liabilities, subordinated, contingent or otherwise, as such debts and liabilities become
absolute and matured, (iii) the Company intends to incur, prior to the second anniversary of the date this representation is made, or believes that it will incur, prior to March 31, 2008, debts that would be beyond its ability to pay as
such debts mature or (iv) the Company has unreasonably small capital with which to conduct the business in which it is engaged as such business is now conducted and is proposed to be conducted. Except as disclosed in Schedule 3(g),
since December 31, 2004, the Company has not declared or paid any dividends or sold any assets outside of the ordinary course of business, individually or in the aggregate, in excess of $100,000. Except as disclosed in
Schedule 3(g), since December 31, 2004, the Company has not had any capital expenditures outside the ordinary course of its business or individually in excess of $100,000. 
 h. Absence of Litigation. Except as set forth on Schedule 3(h), (i) there is no, nor during the past five years
has there been any, action, suit, proceeding, inquiry or investigation before or by any court, public board, government agency, self-regulatory organization or body pending or, to the Knowledge of the Company, threatened against or affecting the
Company, the Common Stock or any of the Company’s Subsidiaries or any of the Company’s or its Subsidiaries’ officers or directors in their capacities as such, and (ii) to the Knowledge of the Company, none of the directors or
officers of the Company has been involved in securities-related litigation during the past five years. None of the matters described in Schedule 3(h), regardless of their outcome, will have a Material Adverse Effect. 
 i. Acknowledgment Regarding Buyer’s Purchase of Notes and Warrants. The Company acknowledges and agrees that each of the
Buyers is acting solely in the capacity of an arm’s length purchaser with respect to the Company in connection with the Transaction Documents and the transactions contemplated hereby and thereby. The Company further acknowledges that each Buyer
is not acting as a financial advisor or fiduciary of the Company (or in any similar capacity) with respect to the Transaction Documents and the transactions contemplated hereby and thereby, and any advice given by any of the Buyers or any of their
respective representatives or agents in connection with the Transaction Documents and the transactions contemplated hereby and thereby is merely incidental to such Buyer’s purchase of the Securities. The Company further represents to each Buyer
that the Company’s decision to enter into the Transaction Documents has been based solely on the independent evaluation by the Company and its representatives. 
 j. No Undisclosed Events, Liabilities, Developments or Circumstances. Except for the issuance of the Notes and Warrants
contemplated by this Agreement, no event, liability, development or circumstance has occurred or exists, or is contemplated to occur, with 

  

 11 

 
respect to the Company or its Subsidiaries or their respective business, properties, credit worthiness, prospects, operations or financial condition, that
would be required to be disclosed by the Company under applicable securities laws at the time this representation is made on a registration statement on Form S-1 filed with the SEC relating to an issuance and sale by the Company of Common Stock
and that has not been publicly disclosed at least five (5) days prior to the date of this Agreement. 
 k. No General
Solicitation. Neither the Company, nor any of its affiliates, nor any Person acting on its or their behalf, has engaged or will engage in any form of general solicitation or general advertising (within the meaning of Regulation D under the
1933 Act) in connection with the offer or sale of the Securities. 
 l. No Integrated Offering. Neither the Company,
nor any of its affiliates, nor any Person acting on its or their behalf has, directly or indirectly, made any offers or sales of any security or solicited any offers to buy any security, under circumstances that would require registration of any of
the Securities under the 1933 Act or cause this offering of the Securities to be integrated with prior offerings by the Company for purposes of the 1933 Act or any applicable stockholder approval provisions of any authority, nor will the
Company take any action or steps that would require registration of the issuance of any of the Securities under the 1933 Act or cause the offering of the Securities to be integrated with other offerings for purposes of the 1933 Act or any
applicable stockholder provision of any authority. 
 m. Dilutive Effect. The Company understands and acknowledges that
the number of Conversion Shares issuable upon conversion of the Notes and the Warrant Shares issuable upon exercise of the Warrants will increase in certain circumstances. The Company further acknowledges that any obligation to issue Conversion
Shares upon conversion of the Notes in accordance with this Agreement and the Notes and its obligation to issue the Warrant Shares upon exercise of the Warrants in accordance with this Agreement and the Warrants is, in each case, absolute and
unconditional regardless of the dilutive effect that such issuance may have on the ownership interests of other stockholders of the Company. Taking the foregoing into account, the Company’s board of directors has determined in its good faith
business judgment that the issuance of the Notes and the Warrants and the consummation of the other transactions contemplated hereby are in the best interests of the Company and its stockholders. 
 n. Employee Relations. The Company is not involved in any labor union dispute nor, to the Knowledge of the Company, is any such
dispute threatened. None of the Company’s employees is a member of a union that relates to such employee’s relationship with the Company, the Company is not a party to a collective bargaining agreement, and the Company believes that its
relations with its employees are good. No executive officer (as defined in Rule 3b-7 under the 1934 Act), nor any other Person whose termination would be required to be disclosed pursuant to Item 5.02 of Form 8-K, has notified
the Company that such Person intends to leave the Company or otherwise terminate such Person’s employment with the Company. No executive officer, to the Knowledge of the Company, is, or is now expected to be, in violation of any material term
of any employment contract, confidentiality, disclosure or proprietary information agreement, non-competition agreement, or any other contract or agreement or any restrictive covenant, and the continued employment of each such executive 

  

 12 

 
officer does not subject the Company to any liability with respect to any of the foregoing matters. The Company is in compliance with all federal, state,
local and foreign laws and regulations relating to employment and employment practices, terms and conditions of employment and wages and hours, except where the failure to be in compliance would not result, either individually or in the aggregate,
in a Material Adverse Effect. 
 o. Intellectual Property Rights. The Company owns or possesses adequate rights or
licenses to use all trademarks, trademark applications and registrations, trade names, service marks, service mark registrations, service names, patents, patent rights, patent applications, copyrights, inventions, licenses, approvals, governmental
authorizations, trade secrets and other intellectual property rights (collectively, “Intellectual Property”) necessary to conduct their respective businesses as now conducted. Schedule 3(o) contains a complete and accurate
list of all patented and registered Intellectual Property owned by the Company and all pending patent applications and applications for the registration of other Intellectual Property owned or filed by the Company. Schedule 3(o) also contains
a complete and accurate list of all licenses and other rights granted by the Company to any third party with respect to Intellectual Property and licenses and other rights with respect to Intellectual Property granted by any third party to the
Company. None of the rights of the Company in its Intellectual Property have expired or terminated, or are expected to expire or terminate within five years from the date of this Agreement. To the Knowledge of the Company, except as described in
Schedule 3(o), there are no third parties who have rights to any of the Intellectual Property owned or licensed by the Company, except for the rights retained by the owners of the Intellectual Property that is licensed to the Company. The
Company has no Knowledge of any infringement by the Company or any of the Company’s licensors or licensees of any Intellectual Property rights of others. The Company has no Knowledge of any infringement by any third parties of any Intellectual
Property owned or licensed by the Company, or of any development of similar or identical trade secrets or technical information by others. There is no claim, action or proceeding being made or brought against, or to the Company’s Knowledge,
being threatened against, the Company or any of the Company’s licensors regarding its Intellectual Property or infringement of other Intellectual Property rights. The Company does not have any Knowledge of any facts or circumstances that could
reasonably be expected to give rise to any of the foregoing. To the Company’s Knowledge, there is no patent or patent application which contains claims that interfere with the issued or pending claims of any of the Intellectual Property owned
or licensed by the Company. The Company, the inventors of the Intellectual Property owned or licensed by the Company, and, to the Company’s Knowledge, the Company’s licensors, have complied with the duty of candor and disclosure set forth
in 37 C.F.R. § 1.56 with respect to each of the patents and patent applications comprising the Intellectual Property owned or licensed by the Company. None of the technology employed by the Company has been obtained or is being used by the
Company in violation of any contractual obligation binding on the Company or, to the Company’s Knowledge, any of its officers, directors or employees in violation of the rights of any persons. The Company has taken reasonable security measures
to protect the secrecy, confidentiality and value of all of its Intellectual Property. Pursuant to the Joint Patent Ownership and License Agreement between the Company and Phage (referred to in such agreement as Phage Biotechnology, Inc.), dated
August 16, 2004 (the “Joint Patent Agreement”), the Company has a 50% undivided ownership interest in each of the U.S. and foreign patent and patent applications listed on Schedule 3(o) and will have an undivided 50%
ownership interest in (i) all 

  

 13 

 
patents issued from the U.S. and foreign patent applications listed on Schedule 3(o), (ii) all other foreign patents and patent applications
related to the U.S. patents and applications listed on Schedule 3(o), including any foreign national patent applications which claim priority to any foreign patent applications, and (iii) any Future Patent Applications (as defined in the
Joint Patent Agreement), including any continuations, divisionals, re-exams, reissues and continuations-in-part that claim priority to any of the issued patents, patent applications and/or Future Patent Applications, and any foreign counterparts
thereof. The Company’s ownership of all of the U.S. patent and patent applications listed on Schedule 3(o) has been duly recorded in the U.S. Patent and Trademark Office. 
 p. Environmental Laws. The Company (i) is in compliance with any and all Environmental Laws (as defined below), (ii) has
received all permits, licenses or other approvals required of it under applicable Environmental Laws to conduct its business and (iii) is in compliance with all terms and conditions of any such permit, license or approval. The term
“Environmental Laws” means all federal, state, local or foreign laws relating to pollution or protection of human health or the environment (including ambient air, surface water, groundwater, land surface or subsurface strata),
including laws relating to emissions, discharges, releases or threatened releases of chemicals, pollutants, contaminants, or toxic or hazardous substances or wastes into the environment, or otherwise relating to the manufacture, processing,
distribution, use, treatment, storage, disposal, transport or handling of hazardous materials, as well as all authorizations, codes, decrees, demands or demand letters, injunctions, judgments, licenses, notices or notice letters, orders, permits,
plans or regulations issued, entered, promulgated or approved thereunder. 
 q. Title. The Company has good and valid
title to all personal property owned by it that is material to the business of the Company, in each case free and clear of all Liens. The Company does not own (rather than lease) any interest in any real property. 
 r. Insurance. The Company is insured by insurers of recognized financial responsibility against such losses and risks and in such
amounts as management of the Company believes to be prudent and customary in the businesses in which the Company is engaged. The Company has not been refused any insurance coverage sought or applied for, and the Company has no reason to believe that
it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business at a cost that would not have a Material Adverse Effect.

 s. Regulatory Permits. The Company possesses all certificates, authorizations, approvals, licenses and permits
issued by the appropriate federal, state or foreign regulatory authorities necessary to conduct its business as presently conducted (“Permits”), including all Permits required by the United States Food and Drug Administration (the
“FDA”) (including Permits required by the FDA for the Company’s drug candidate, Cardio Vascu-GrowTM, in its current stage of development) or any other federal, state or foreign agencies or bodies engaged in the regulation
of pharmaceuticals or biohazardous materials, and the Company has not received any notice of proceedings relating to the revocation or modification of any such Permit. For purposes of this Agreement, “Cardio Vascu-GrowTM” means
a protein which is a member of the fibroblast growth factor family Fibroblast Growth Factor-1, or FGF-1, or any 

  

 14 

 
derivative or mutant of such fibroblast growth factor family, developed by the Company for the purpose of commercializing after approval by the FDA or
similar foreign agencies for sale as a biologic drug. The Company is not in violation of any of the rules, regulations or requirements of the OTC Bulletin Board (the “Principal Market”; provided however, that, if after the date of
this Agreement the Common Stock is listed on a national securities exchange, the NASDAQ National Market (or any successor thereto) or the NASDAQ Capital Market, the “Principal Market” shall mean such exchange or market, as
applicable), and has no Knowledge of any facts or circumstances that could reasonably lead to suspension or termination of trading of the Common Stock on the Principal Market. Since March 10, 2004, (i) the Company’s Common Stock has
been listed on the Principal Market, (ii) trading in the Common Stock has not been suspended by the SEC or the Principal Market and (iii) the Company has received no communication, written or oral, from the SEC or the Principal Market
regarding the suspension or termination of trading of the Common Stock on the Principal Market. The Company satisfies the quantitative standards for initial listing of the Common Stock on the NASDAQ Capital Market, as set forth in NASDAQ Marketplace
Rules 4310, 4350 and 4420. The Company has not received any communication from The Nasdaq Stock Market regarding the resignation of any director or executive officer as a condition to listing of the Common Stock on the NASDAQ Capital Market.

 t. Internal Accounting Controls; Disclosure Controls and Procedures. The Company maintains a system of internal
accounting controls sufficient to provide reasonable assurance that (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of
financial statements in conformity with GAAP and to maintain asset and liability accountability, (iii) access to assets or incurrence of liability is permitted only in accordance with management’s general or specific authorization and
(iv) the recorded accountability for assets and liabilities is compared with the existing assets and liabilities at reasonable intervals and appropriate action is taken with respect to any differences. The Company has timely filed and made
available to the Buyers all certifications and statements required by (A) Rule 13a-14 or Rule 15d-14 under the 1934 Act and (B) Section 906 of Sarbanes Oxley with respect to any Company SEC Documents. The Company maintains
disclosure controls and procedures required by Rule 13a-15 or Rule 15d-15 under the 1934 Act; such controls and procedures are effective to ensure that the information required to be disclosed by the Company in the reports that it
files with or submits to the SEC (X) is recorded, processed, summarized and reported accurately within the time periods specified in the SEC’s rules and forms and (Y) is accumulated and communicated to the Company’s management,
including its principal executive officer and principal financial officer, as appropriate to allow timely decisions regarding required disclosure. The Company maintains internal control over financial reporting required by Rule 13a-14 or
Rule 15d-14 under the 1934 Act; such internal control over financial reporting is effective and does not contain any material weaknesses. 
 u. No Materially Adverse Contracts, Etc. The Company is not subject to any charter, corporate or other legal restriction, or any judgment, decree, order, rule or regulation that in the judgment of the
Company’s officers has, or is expected in the future to have, a Material Adverse Effect. The Company is not a party to any contract or agreement that in the judgment of the Company’s officers has or is expected to have a Material Adverse
Effect. 
  

 15 

 v. Tax Status. The Company (i) has made or filed all foreign, federal and
state income and all other tax returns, reports and declarations required by any jurisdiction to which it is subject (unless and only to the extent that the Company has set aside on its books provisions reasonably adequate for the payment of all
unpaid and unreported taxes), (ii) has paid all taxes and other governmental assessments and charges that are material in amount shown or determined to be due on such returns, reports and declarations, except those being contested in good faith
and for which the Company has made appropriate reserves on its books, and (iii) has set aside on its books provisions reasonably adequate for the payment of all taxes for periods subsequent to the periods to which such returns, reports or
declarations (referred to in clause (i) above) apply. There are no unpaid taxes in any material amount claimed in writing to be due by the taxing authority of any jurisdiction, and to the Company’s Knowledge, there is no basis for any such
claim. 
 w. Transactions With Affiliates. Except as set forth in Schedule 3(w), no Related Party (as
defined in Section 4(j)) of the Company, nor any of its affiliates, is presently, or has been within the past two years, a party to any transaction, contract, agreement, instrument, commitment, understanding or other arrangement or relationship
with the Company (other than directly for services as an employee, officer and/or director), whether for the furnishing of services to or by, providing for rental of real or personal property to or from, or otherwise requiring payments or
consideration to or from any such Related Party. Except as set forth in Schedule 3(w), no Related Party of the Company or any of its affiliates, has any direct or indirect ownership interest in any Person (other than ownership of less
than 1% of the outstanding common stock of a publicly traded corporation) in which the Company has any direct or indirect ownership interest or with which the Company competes or has a business relationship. 
 x. Application of Takeover Protections. The Company and its Board of Directors have taken all necessary action, if any, in order to
render inapplicable any control share acquisition, business combination or other similar anti-takeover provision under the Certificate of Incorporation or the laws of Delaware that is or could become applicable to the Buyers as a result of the
transactions contemplated by this Agreement, including the Company’s issuance of the Securities and the Buyers’ ownership of the Securities. 
 y. Rights Agreement. The Company has not adopted a stockholder rights plan or similar arrangement relating to accumulations of beneficial ownership of Common Stock or a change in control of the Company.

 z. Foreign Corrupt Practices. Neither the Company, nor to the Company’s Knowledge, any director, officer,
agent, employee or other Person acting on behalf of the Company has, in the course of its actions for, or on behalf of, the Company, used any corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to
political activity; made any direct or indirect unlawful payment to any foreign or domestic government official or employee from corporate funds; violated or is in violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as
amended; or made any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic government official or employee. 
  

 16 

 aa. No Other Agreements. As of the Closing Date, the Company has not, directly or
indirectly, made any agreements with any Buyers relating to the terms or conditions of the transactions contemplated by the Transaction Documents except as set forth in the Transaction Documents. 
 bb. Outstanding Indebtedness; Liens. Payments of principal and other payments due under the Notes will, upon issuance in connection
with the Closings, rank senior to all other Indebtedness (as defined in the Notes) and trade accounts payable of the Company . Except as set forth on Schedule 3(bb), (I) the Company has no outstanding Indebtedness or trade accounts
payable, (II) there are no Liens on any of the assets of the Company, and (III) there are no financing statements securing obligations of any amounts filed against the Company or any of its assets. 
 cc. Leases. Schedule 3(cc) contains a complete and correct list of all the real property and facilities that
(i) are leased or otherwise possessed by the Company, (ii) in connection with which the Company has entered into an option agreement, participation agreement or acquisition agreement or (iii) the Company has agreed (or has an option)
to lease or otherwise acquire or may be obligated to lease or otherwise acquire in connection with the conduct of its business (collectively, the “Real Property”). Schedule 3(cc) also contains a complete and correct
list, along with a summary of material terms, of all leases and other agreements with respect to which the Company is a party or otherwise bound or affected with respect to the Real Property (the “Real Property Leases”). Except as
set forth in Schedule 3(cc), the Company is the sole legal and equitable owner of a leasehold interest in all of the Real Property and possesses good, marketable and defensible title thereto, free and clear of all Liens (other than
Permitted Liens (as defined in the Notes) and other matters affecting title to such leasehold that could impair the ability of the Company to realize the benefits of the rights provided to any of them under the Real Property Leases. All of the Real
Property Leases are valid and in full force and effect and are enforceable against all parties thereto, neither the Company nor, to the Company’s Knowledge, any other party thereto is in default in any material respect under any of such Real
Property Leases, and no event has occurred which with the giving of notice or the passage of time or both could constitute a default under, or otherwise give any party the right to terminate, any of the Real Property Leases, or could adversely
affect the Company’s interest in and title to any of the Real Property. No Real Property Lease is subject to termination, modification or acceleration as a result of the transactions contemplated hereby. To the Knowledge of the Company, the
Real Property is properly zoned for its present use. To the Knowledge of the Company, the Real Property complies with all applicable building codes, ordinances and other similar legal requirements. There are no pending or, to the Knowledge of the
Company, threatened condemnation, eminent domain or similar proceedings, or litigation or other proceedings affecting the Real Property, or any portion or portions thereof. To the Knowledge of the Company, there are no pending or threatened
requests, applications or proceedings to alter or restrict any zoning or other use restrictions applicable to the Real Property that would interfere with the conduct of the Company’s business as presently conducted. 
 dd. Communication with the FDA. The Company has no Knowledge of any pending communication from the FDA that would cause the Company
to revise its strategy for 

  

 17 

 
seeking marketing approval from the FDA for Cardio Vascu-GrowTM or any of the Company’s other products under development as described in the SEC
Documents. 
 ee. Studies and Other Preclinical and Clinical Tests. The studies, tests and preclinical and clinical
trials conducted by or on behalf of the Company that are described in the SEC Documents were and, if still pending, are being conducted in all material respects in accordance with experimental protocols, procedures and controls pursuant to accepted
professional and scientific standards; the descriptions of the results of such studies, tests and trials contained in the SEC Documents are accurate and complete; and neither the Company nor any of its Subsidiaries has received any notices or
correspondence from the FDA or any foreign, state or local governmental body exercising comparable authority or any Institutional Review Board or comparable authority requiring the termination, suspension or material modification of any studies,
tests or preclinical or clinical trails conducted by or on behalf of the Company. 
 ff. Investment Company. The
Company is not, and upon the Closing will not be, an “investment company,” a company controlled by an “investment company,” or an “affiliated person” of, or “promoter” or “principal underwriter” for,
an “investment company,” as such terms are defined in the Investment Company Act of 1940, as amended. 
 4. COVENANTS.

 a. Best Efforts. Each party shall use its best efforts to timely satisfy each of the conditions to be satisfied by
it as provided in Sections 6 and 7 of this Agreement. 
 b. Form D and Blue Sky. The Company agrees to timely
file a Form D with respect to the Securities as required under Regulation D and to provide a copy thereof to each Buyer promptly after such filing. The Company shall, on or before the Closing Date, take such action as the Company shall
reasonably determine is necessary in order to obtain an exemption for, or to qualify the Securities for, sale to the Buyers at the Closing pursuant to this Agreement under applicable securities or “Blue Sky” laws of the states of the
United States, and shall provide evidence of any such action so taken to the Buyers on or prior to the Closing Date. The Company shall make all filings and reports relating to the offer and sale of the Securities required under applicable securities
or “Blue Sky” laws of the states of the United States following the Closing Date. 
 c. Reporting Status.
Until the later of (i) the date that is one year after the date as of which the Investors (as that term is defined in the Registration Rights Agreement) may sell all of the Conversion Shares and the Warrant Shares without restriction pursuant
to Rule 144(k) promulgated under the 1933 Act (or successor thereto), and (ii) the date on which no Notes or Warrants remain outstanding (the “Reporting Period”), the Company shall timely file all reports required to
be filed with the SEC pursuant to the 1934 Act, and the Company shall not terminate its status as an issuer required to file reports under the 1934 Act even if the 1934 Act or the rules and regulations thereunder would otherwise
permit such termination. 
 d. Use of Proceeds. The Company will use the proceeds from the sale of the Notes and the
Warrants first (i) to pay expenses and commissions related to the sale of the Notes 

  

 18 

 
and the Warrants, and (ii) to fund clinical trials of Cardio Vascu-GrowTM, and then for working capital, in each case as more specifically described
and in the amounts indicated in Schedule 4(d). 
 e. Financial Information. The Company agrees to send the
following to each Investor (as that term is defined in the Registration Rights Agreement) during the Reporting Period: (i) within one (1) day after the filing thereof with the SEC, a copy of its annual reports on Form 10-K, its
quarterly reports on Form 10-Q, any current reports on Form 8-K and any registration statements (other than on Form S-8) or amendments or supplements filed pursuant to the 1933 Act, unless the foregoing are filed with the SEC
through EDGAR and are immediately available to the public through EDGAR; (ii) on the same day as the release thereof, facsimile copies of all press releases issued by the Company or any of its Subsidiaries, except to the extent such release is
available through Bloomberg Financial Markets (or any successor thereto) contemporaneously with such issuance; and (iii) copies of any notices and other information made available or given to the stockholders of the Company generally,
contemporaneously with the making available or giving thereof to the stockholders. 
 f. Reservation of Shares. The
Company shall take all action necessary to at all times have authorized, and reserved for the purpose of issuance, no less than 200% of the number of shares of Common Stock needed to provide for issuance of the Conversion Shares upon conversion of
all outstanding Notes (without regard to any limitations on conversion thereof) and no less than 150% of the aggregate number of shares of Common Stock issuable upon exercise of all outstanding Warrants (without regard to any limitations on exercise
thereof). 
 g. Listing. The Company shall take all actions necessary to remain eligible for quotation of its
securities on the OTC Bulletin Board and to cause all of the Registrable Securities (as defined in the Registration Rights Agreement) covered by a Registration Statement to be quoted thereon, unless listed on a national securities exchange, the
NASDAQ National Market or the NASDAQ Capital Market. The Company shall use its best efforts (other than requiring the resignation of any executive officer of the Company as an executive officer or director of the Company) to secure the listing of
the Common Stock on the NASDAQ Capital Market as promptly as practicable after the date of this Agreement. In the event the Company is unable to secure the listing of the Common Stock on the NASDAQ Capital Market after exercising such best efforts
to do so, the Company shall use its best efforts (other than requiring the resignation of any executive officer of the Company as an executive officer or director of the Company) to secure the listing of the Common Stock on the American Stock
Exchange as promptly as practicable. The Company shall promptly secure the listing of all of the Registrable Securities upon each national securities exchange and automated quotation system, if any, upon which shares of Common Stock are then listed
(subject to official notice of issuance) and shall maintain, so long as any other shares of Common Stock shall be so listed, such listing of all Registrable Securities from time to time issuable under the terms of the Transaction Documents. The
Company shall not, shall cause each of its Majority-Owned Subsidiaries not to, and shall not authorize any of its Minority-Owned Subsidiaries to, take any action which would be reasonably expected to result in the suspension or termination of
trading of the Common Stock on the Principal Market. The Company shall pay all fees and expenses in connection with satisfying its obligations under this Section 4(g). For purposes of this Agreement, the Company shall be 

  

 19 

 
deemed to have authorized a Minority-Owned Subsidiary to take an action if the Company or any of its Majority-Owned Subsidiaries causes, directs or expressly
authorizes such Minority-Owned Subsidiary to take such action or fails to (A) vote its equity interest against the taking of such action (if a vote of equity holders is taken with respect to such action), or (B) cause any directors,
managers or similar officials appointed by it to vote against the taking of such action (if a vote of directors, managers or similar officials is taken with respect to such action). 
 h. Expenses. Subject to Section 9(k) below, at the Closing, the Company shall pay each of the Buyers a non-accountable
reimbursement amount equal to such Buyer’s Reimbursement Allocation Percentage, as set forth opposite such Buyer’s name on the Schedule of Buyers (which for all Buyers shall total 1.0%), multiplied by the original principal
amount of Notes purchased by all the Buyers at the Closing to cover due diligence, negotiating and preparing the Transaction Documents and consummating the transactions contemplated thereby (less at the Closing, in the case of HFTP Investment
L.L.C., a Buyer (“HFTP”), the $35,000 previously paid to HFTP as a reimbursement). The amount payable to each Buyer pursuant to the preceding sentence at the Closing shall be withheld as an off-set by such Buyer from its Purchase
Price to be paid by it at the Closing. 
 i. Disclosure of Transactions and Other Material Information. Contemporaneous
with or prior to the earlier of (i) the Company’s first public announcement of the transactions contemplated hereby and (ii) 8:00 a.m. (New York City time) on the second (2nd) Business Day following the Closing Date, the
Company shall file a Form 8-K with the SEC describing the terms of the transactions contemplated by the Transaction Documents and including as exhibits to such Form 8-K this Agreement (including the schedules hereto), the Form of Note, the
Registration Rights Agreement, the Form of Initial Warrant, the Form of Repurchase Warrant, the Security Agreement, the Patent Security Agreement, the Pledge Agreement, the Form of Guaranty and the Montano Guaranty, in the form required by the 1934
Act (the “Announcing Form 8-K”). The Company shall not make any public announcement regarding the transactions contemplated hereby prior to the Closing. The Company represents and warrants that, from and after the filing of the
Announcing Form 8-K with the SEC, no Buyer shall be in possession of any material nonpublic information received from the Company, any of its Subsidiaries or any of their respective officers, directors, employees or agents. The Company shall
not, and shall cause each of its Subsidiaries and its and each of their respective officers, directors, employees and agents to, provide any Buyer with any material nonpublic information regarding the Company or any of its Subsidiaries from and
after the filing of the Announcing Form 8-K with the SEC without the express prior written consent of such Buyer. In the event of a breach of the foregoing covenant by the Company, any of its Subsidiaries, or any of its or their respective
officers, directors, employees and agents, in addition to any other remedy provided herein or in the Transaction Documents, a Buyer shall have the right to make a public disclosure, in the form of a press release, public advertisement or otherwise,
of such material nonpublic information without the prior approval by the Company, its Subsidiaries, or any of its or their respective officers, directors, employees or agents. No Buyer shall have any liability to the Company, its Subsidiaries, or
any of its or their respective officers, directors, employees, stockholders or agents for any such disclosure. Subject to the foregoing, neither the Company nor any Buyer shall issue any press releases or any other public statements with respect to
the transactions contemplated hereby or disclosing the name of any Buyer; provided, however, that 

  

 20 

 
the Company shall be entitled, without the prior approval of any Buyer, to make any press release or other public disclosure with respect to such
transactions (i) in substantial conformity with the Announcing Form 8-K and contemporaneously therewith and (ii) as is required by applicable law and regulations (provided that each Buyer shall be consulted by the Company in
connection with any such press release or other public disclosure prior to its release and shall be provided with a copy thereof). 
 j. Transactions With Affiliates. From the date of this Agreement until the first date following the Closing Date on which no Notes or Warrants are outstanding, without the prior written consent of the holders of two-thirds
(2/3) of the aggregate principal amount of the outstanding Notes, the Company shall not, shall cause each of its Majority-Owned Subsidiaries not to, and shall not authorize any of its Minority-Owned Subsidiaries to, enter into, amend, modify or
supplement any transaction, contract, agreement, instrument, commitment, understanding or other arrangement with any of its or any Subsidiary’s officers, directors, Persons who were officers or directors at any time during the previous two
years, stockholders, or affiliates of the Company or any of its Subsidiaries, or with any individual related by blood, marriage or adoption to any such individual or with any entity in which any such entity or individual owns a beneficial interest
(each a “Related Party”), except for customary employment arrangements and benefit programs on reasonable terms. “Affiliate” for purposes hereof means, with respect to any Person, another Person that, directly or
indirectly, (i) has an equity interest in that Person, (ii) has a common ownership with that Person, (iii) controls that Person, (iv) is controlled by that Person or (v) shares common control with that Person.
“Control” or “controls” for purposes hereof means that a person or entity has the power, direct or indirect, to conduct or govern the policies of another Person. Without limiting the foregoing, from the date of this
Agreement until the first date following the Closing Date on which no Notes or Warrants are outstanding, the Company will at all times comply with the CVBT Conflicts of Interest/Related Party Transactions Procedures attached hereto as Schedule
4(j) (the “Affiliate Transactions Policy”), and will not terminate the Affiliate Transactions Policy or amend, modify, supplement or otherwise revise the provisions thereof without the prior express written consent of the
holders of a majority of the outstanding principal amount of the Notes. 
 k. Stockholder Approval. If at any time
following the Closing Date (the “Stockholder Approval Triggering Date”), the sum of (i) the number of Conversion Shares, Warrant Shares and Interest Shares (as defined in the Notes) previously issued by the Company, plus
(ii) the remaining number of Conversion Shares into which the outstanding Notes are then convertible (without regard to any limitation on conversion), plus (iii) the remaining number of Warrant Shares into which the outstanding Warrants
are then exercisable (without regard to any limitation on exercise), is greater than fifty percent (50%) of the Exchange Cap (as defined in the Notes), then the Company shall solicit approval by the Company’s stockholders of the
Company’s issuance of all of the Conversion Shares and Warrant Shares, as set forth in this Agreement, the Notes and the Warrants in accordance with the rules and regulations applicable to companies with securities listed on the Principal
Market (such approval being referred to herein as “Stockholder Approval”), with the recommendation of the Company’s Board of Directors that such proposal be approved. The Company shall file with the SEC a preliminary version of
the proxy statement to be provided by the Company to its stockholders in connection with soliciting Stockholder Approval as soon as possible, but in no event later than thirty (30)

  

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days after the Stockholder Approval Triggering Date (the “Proxy Statement Filing Due Date”), and each Buyer and a counsel of its choice
shall be entitled to review, prior to filing with the SEC, such proxy statement, which shall not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the
statements therein, in light of the circumstances under which they were made, not misleading. The Company shall hold a meeting of its stockholders as soon as possible but in no event later than seventy-five (75) days after the Stockholder
Approval Triggering Date (the “Stockholder Meeting Deadline”). If the Company fails to file the proxy statement referred to above by the Proxy Statement Filing Due Date or fails to hold a meeting of its stockholders by the
Stockholder Meeting Deadline, then, as partial relief (which remedy shall not be exclusive of any other remedies available at law or in equity), the Company shall pay to each holder of Notes an amount in cash equal to the product of (i) the
aggregate principal amount of all Notes held by such holder, multiplied by (ii) .02 multiplied by (iii) the quotient of (x) the sum of (A) the number of days after the Proxy Statement Filing Due Date and prior to the date that
the proxy statement referred to above is filed with the SEC and (B) the number of days after the Stockholder Meeting Deadline and prior to the date that a meeting of the Company’s stockholders is held, divided by (y) 30. The Company
shall make the payments referred to in the immediately preceding sentence within five (5) days of the earlier of (I) the filing of the proxy statement or the holding of the meeting of the Company’s stockholders, the failure of which
resulted in the requirement to make such payments, and (II) the last day of each 30-day period beginning on the Proxy Statement Filing Due date or the Stockholder Meeting Deadline, as the case may be. In the event the Company fails to make such
payments in a timely manner, such payments shall bear interest at the rate of 2.0% per month (pro rated for partial months) until paid in full. 
 l. Corporate Existence; Real Property Leases. From the date of this Agreement until the first date following the Closing Date on which no Notes or Warrants are outstanding, the Company shall maintain its
corporate existence and shall not sell all or substantially all of the Company’s assets (including, for the avoidance of any doubt, all or substantially all of the assets of the Company’s Majority-Owned Subsidiaries in the aggregate),
except in the event of a merger or consolidation or sale or transfer of all or substantially all of the Company’s assets (including, for the avoidance of any doubt, all or substantially all of the assets of the Company’s Majority-Owned
Subsidiaries in the aggregate) where (i) the surviving or successor entity in such transaction (A) assumes the Company’s obligations hereunder and under the agreements and instruments entered into in connection herewith and
(B) is a publicly traded corporation whose common stock is quoted on or listed for trading on the New York Stock Exchange or the NASDAQ National Market (or a successor thereto), and (ii) immediately before and immediately after giving
effect to such transaction, no Triggering Event (as defined in the Notes) or Event of Default (as defined in the Notes) shall have occurred and be continuing. 
 m. Pledge of Securities. The Company acknowledges and agrees that the Securities may be pledged by an Investor (as defined in the
Registration Rights Agreement) in connection with a bona fide margin agreement or other loan secured by the Securities. The pledge of Securities shall not be deemed to be a transfer, sale or assignment of the Securities hereunder, and no Investor
effecting any such pledge of Securities shall be required to provide the Company with any notice thereof or otherwise make any delivery to the Company pursuant 

  

 22 

 
to this Agreement or any other Transaction Document, including Section 2(f) of this Agreement; provided that an Investor and its pledgee shall be
required to comply with the provisions of Section 2(f) in order to effect a sale, transfer or assignment of Securities to such pledgee. The Company hereby agrees to execute and deliver such documentation as a pledgee of the Securities may
reasonably request in connection with a pledge of the Securities to such pledgee by an Investor. 
 n. Priority of
Notes. From the date of this Agreement until the first date following the Closing Date on which no Notes are outstanding, the Company shall not, shall cause each of its Majority-Owned Subsidiaries not to, and shall not authorize any of its
Minority-Owned Subsidiaries to, (a) issue, incur, assume, maintain, suffer to exist or extend the term of any Indebtedness (as defined in the Notes), except for (I) Indebtedness under the Notes, (II) Indebtedness (A) the holders
of which agree in writing to be subordinate to the Notes on terms and conditions acceptable to the Buyers, including with regard to interest payments and repayment of principal, (B) which does not mature or otherwise require or permit
redemption or repayment prior to or on the Maturity Date (as defined in the Notes) of any Notes then outstanding, and (C) which is not secured by any of the assets of the Company or any of its Subsidiaries (“Permitted Subordinated
Indebtedness”), (III) Indebtedness solely between the Company and/or one of its domestic Subsidiaries on the one hand, and the Company and/or one of its domestic Subsidiaries on the other, provided that in each case a majority of the
equity of any such domestic Subsidiary is directly or indirectly owned by the Company, such domestic Subsidiary is controlled by the Company, such domestic Subsidiary is at such time party to the Security Agreement, such domestic Subsidiary has
executed and delivered to the holders of the Notes a Guaranty, substantially in the form attached as Exhibit J (the “Guaranty”), pursuant to which such Subsidiary will agree to guaranty certain obligations of the Company, and
100% of the capital stock of such Subsidiary owned, directly or indirectly, by the Company has been pledged in favor of the Collateral Agent, as collateral agent for the Buyers, (IV) Indebtedness to contract research organizations, hospitals or
similar entities or organizations incurred in the ordinary course of business in connection with FDA approval related trials of the Company’s products not unpaid in excess of 30 days from the receipt of invoice and not exceeding at any one time
an aggregate of $5,000,000, (V) Indebtedness under that certain Guaranty of Sublease, dated August 24, 2004, made by the Company in favor of The Regents of the University of California with respect to the obligations of Phage under that
certain Sublease Agreement, dated August 24, 2004, between Phage and The Regents of the University of California, as such Guaranty of Sublease and Sublease Agreement are in effect on the date of the Securities Purchase Agreement, without
amendment, modification, supplement or other revision thereto, or (VI) Indebtedness under that certain Standard Lease Guaranty, dated March, 2006, made by the Company in favor of Canta Rana Ranch, L.P. with respect to the obligations of Phage under
that certain Standard Industrial Net Lease, dated March, 2006, by and between Phage and Canta Rana Ranch, L.P., as such Standard Lease Guaranty and Standard Industrial Net Lease are in effect on the date of the Securities Purchase Agreement, without
amendment, modification, supplement or other revision thereto; (b) issue, incur, assume, maintain, suffer to exist or extend the term of any Indebtedness in a principal amount in excess of $100,000 where the proceeds of such Indebtedness are to
be used to develop, or in connection with the development, of assets in which the holders of the Notes do not have a valid perfected, first priority security interest; (c) issue any capital stock of the Company or any Subsidiary redeemable
prior to or on the Maturity Date of 

  

 23 

 
any Notes then outstanding; (d) directly or indirectly, create, assume or suffer to exist any Lien, other than a Permitted Lien, on any asset now owned
or hereafter acquired by the Company or any of its Subsidiaries or (e) redeem or otherwise repay in cash any principal of any Indebtedness (other than Indebtedness under the Notes and Indebtedness permitted by clauses (IV), (V) and (VI) of
clause (a) above). The provisions of this Section 4(n) are in furtherance of Section 13 of the Notes, and in no way limit the other restrictions on or obligations of the Company pursuant to Section 13 of the Notes or otherwise.

 o. Restriction on Loans; Investments; Subsidiary Equity. From the date of this Agreement until the first date
following the Closing Date on which no Notes are outstanding, the Company shall not, shall cause each of its Majority-Owned Subsidiaries not to, and shall not authorize any of its Minority-Owned Subsidiaries to, (i) except for Permitted
Investments (as defined herein) in which the holders of the Notes have a valid, perfected first priority security interest, make any loans to, or investments in, any other Person, including through lending money, deferring the purchase price of
property or services (other than trade accounts receivable on terms of ninety (90) days or less), purchasing any note, bond, debenture or similar instrument, entering into any letter of credit, guaranteeing (or taking any action that has the
effect of guaranteeing) any obligations of any other Person, or acquiring any equity securities of, or other ownership interest in, or making any capital contribution to any other Person (provided, however that the Company and its domestic
Subsidiaries may make loans to each other to the extent the incurrence of the Indebtedness represented by such loans would be permitted by Section 4(n)(a)(III) and not otherwise be prohibited by Section 4(n)), or (ii) issue, transfer
or pledge any capital stock or equity interest in any Subsidiary to any Person other than the Company. “Permitted Investments” means any investment in (A) direct obligations of the United States, or obligations guaranteed by
the United States, in each case which mature and become payable within 90 days of the investment by the Company or any Subsidiary, (B) commercial paper rated at least A-1 by Standard & Poor’s Ratings Service and P-1 by
Moody’s Investors Services, Inc., (C) time deposits with, including certificates of deposit issued by, any office located in the United States of any bank or trust company which is organized under the laws of the United States or any State
thereof and has capital, surplus and undivided profits aggregating at least $500,000,000 and which issues (or the parent of which issues) certificates of deposit or commercial paper with a rating described in clause (B) above, in each case
which mature and become payable within 90 days of the investment by the Company or any Subsidiary, (D) repurchase agreements with respect to securities described in clause (A) above entered into with an office of a bank or trust company
meeting the criteria specified in clause (C) above, provided in each case that such investment matures and becomes payable within 90 days of the investment by the Company or any Subsidiary, or (E) any money market or mutual fund which
invests only in the foregoing types of investments and the liquidity of which is satisfactory to the Secured Party (as defined in the Security Agreement). Notwithstanding anything to the contrary in this Agreement or any other Transaction Document,
the Company may, following the Closing Date, (X) organize and form a Subsidiary under the laws of Japan or any jurisdiction thereof (the “Japan Subsidiary”); provided that the capital contribution of the Company and any
Majority-Owned Subsidiaries to the Japan Subsidiary is not greater than $200,000 in the aggregate, the Company owns at all times not less than 80% of the outstanding voting power and equity interests of the Japan Subsidiary, and the Company pledges
all of the equity interests of the Japan Subsidiary owned by the Company to the Buyers as collateral for the Notes pursuant to a 

  

 24 

 
pledge agreement substantially similar in form and substance to the Pledge Agreement, (Y) sell or otherwise transfer up to 20% in the aggregate of the
outstanding voting power and/or equity interests of the Japan Subsidiary to any Person(s) that is not an Affiliate of the Company; provided, that any such sale or transfer may be made to an Affiliate of the Company with the prior express written
consent of the holders of at least two-thirds (2/3) of the aggregate principal amount of the Notes then outstanding, and (Z) loan up to $800,000 in the aggregate on an unsecured and unsubordinated basis to the Japan Subsidiary. 

p. Restriction on Purchases or Payments. From the date of this Agreement until the first date following the Closing Date on
which no Notes are outstanding, the Company shall not, shall cause each of its Majority-Owned Subsidiaries not to, and shall not authorize any of its Minority-Owned Subsidiaries to, (i) declare, set aside or pay any dividends on or make any
other distributions (whether in cash, stock, equity securities or property) in respect of any capital stock or split, combine or reclassify any capital stock or issue or authorize the issuance of any other securities in respect of, in lieu of or in
substitution for any capital stock or set any record date with respect to any of the foregoing; provided however, that any Subsidiary may declare, set aside or pay any dividends on or make any other distributions (whether in cash, stock, equity
securities or property) in respect of any of its capital stock that is held solely by the Company or by a domestic Subsidiary, provided that a majority of the equity of such domestic Subsidiary is directly or indirectly owned by the Company, such
domestic Subsidiary is controlled by the Company, such domestic Subsidiary is at such time party to the Security Agreement, such domestic Subsidiary has executed and delivered to the holders of the Notes the Guaranty, and 100% of the capital stock
of such Subsidiary owned, directly or indirectly, by the Company has been pledged in favor of the Collateral Agent, as collateral agent for the Buyers, (ii) purchase, redeem or otherwise acquire, directly or indirectly, any shares of the
Company’s capital stock or the capital stock of any of its Subsidiaries, except repurchases of unvested shares at cost in connection with the termination of the employment relationship with any employee pursuant to stock option or purchase
agreements in effect on the date of this Agreement and set forth on Schedule 3(c), or (iii) grant, issue or sell any Options, Convertible Securities or rights to purchase stock, warrants, securities or other property pro rata to the
record holders of any class of its capital stock. From the date of this Agreement until the first date following the Closing Date on which no Notes or Warrants are outstanding, the Company shall not, shall cause each of its Majority-Owned
Subsidiaries not to, and shall not authorize any of its Minority-Owned Subsidiaries to, enter into any agreement which would limit or restrict the Company’s or any of its Subsidiaries’ ability to perform under, or take any other voluntary
action to avoid or seek to avoid the observance or performance of any of the terms to be observed or performed by it under, this Agreement, the Notes, the Registration Rights Agreement, the Warrants and the Security Documents (as defined in the
Security Agreement). 
 q. Prohibition Against Variable Priced Securities. From the date of this Agreement until the
first date following the Closing Date on which no Notes or Warrants are outstanding, the Company shall not in any manner issue or sell any Options (as defined below) or Convertible Securities (as defined below) that are convertible into or
exchangeable or exercisable for shares of Common Stock at a price that varies or may vary with the market price of the Common Stock, including by way of one or more resets to a fixed price or increases in the number of shares of Common Stock issued
or issuable, or at a price that upon the passage of time 

  

 25 

 
or the occurrence of certain events automatically is reduced or is adjusted or at the option of any Person may be reduced or adjusted, whether or not based
on a formulation of the then current market price of the Common Stock. For purposes of this Agreement, “Convertible Securities” means any stock or securities (other than Options) directly or indirectly convertible into or
exchangeable or exercisable for shares of Common Stock and “Options” means any rights, warrants or options to subscribe for or purchase shares of Common Stock or Convertible Securities. 
 r. Certain Required Conversions or Exercises. So long as a Buyer holds any Notes or Warrants, if such Buyer or any of its
affiliates, directly or indirectly, engages in any transaction constituting a Short Sale (as defined below) and immediately following such Short Sale the aggregate short position (including aggregate open “put equivalent positions”) with
respect to the Common Stock maintained by such Buyer and its affiliates at such time exceeds such Buyer’s Permitted Share Position, then within six (6) Trading Days (as defined in the Notes) of such Short Sale such Buyer or its affiliates
will deliver a Conversion Notice (as defined in the Notes) or an Exercise Notice (as defined in the Warrants) entitling such Buyer or its affiliates to receive a number of shares of Common Stock at least equal to the number of shares of Common Stock
sold or subject to such Short Sale which were in excess of such Buyer’s Permitted Share Position at the time of such Short Sale or, if less, equal to such number of shares issuable upon conversion and exercise of all the Notes and Warrants held
by such Buyer and its affiliates Notwithstanding the foregoing, the requirements set forth in the preceding sentence shall not apply (a) on and after the first day after the Closing Date on which there shall have occurred a Triggering Event or
an Event of Default (each as defined in the Notes) or an event that with the passage of time or the giving of notice would constitute a Triggering Event or an Event of Default; or (b) on or after the first date after the Closing Date on which a
Change of Control (as defined in the Notes) shall have been consummated or there shall have been a public announcement of a pending, proposed or intended Change of Control. Subject to the foregoing requirements, the Company acknowledges and agrees
that nothing in this Section 4(r) or elsewhere in this Agreement, the Notes, the Warrants or the Registration Rights Agreement prohibits any Buyer (or any of its affiliates) from, and each Buyer (and its affiliates) is permitted to, engage,
directly or indirectly, in hedging transactions involving the Notes, the Warrants and the Common Stock (including, without limitation, by way of short sales, purchases and sales of options, swap transactions and synthetic transactions) at any time.
For purposes of this Section 4(r) the following terms have the following meanings: (I) “Permitted Share Position” means, with respect to any time of determination, the sum of (A) the number of shares of Common Stock
issuable upon exercise of the Warrants held by the applicable Buyer and its affiliates (without regard to any limitations on exercise) at such time, plus (B) the number of shares of Common Stock held by the applicable Buyer and its affiliates
at such time; and (II) “Short Sale” means a “short sale” (as defined in Rule 3b-3 under the 1934 Act) of shares of Common Stock or establishing an open “put equivalent position” (within the meaning of Rule
16a-1(h) under the 1934 Act) with respect to the Common Stock. 
 s. Joint Patent Ownership and License Agreement. On
or prior to June 30, 2006, the Company will (i) cause the Joint Patent Agreement to be amended and restated to be in a form approved in writing by the holders of at least a majority of the aggregate principal of the Notes outstanding as of
the date of such amendment and restatement (which approval shall not 

  

 26 

 
be unreasonably withheld so long as such form expressly (by correct title, country, application number and patent number (with respect to issued patents))
provides the Company with ownership of each of the U.S. and foreign patents and patent applications listed on Schedule 3(o) and (ii) execute all assignments and other documents, make all filings and otherwise take all actions necessary
to record the Company’s ownership interest in each of the foreign patents and patent applications (and all patents issued therefrom) listed on Schedule 3(o) in the respective countries set forth on Schedule 3(o). Except as
provided in the preceding sentence, from the date of this Agreement until the first date following the Closing Date on which no Notes or Warrants are outstanding, the Company will not (X) terminate or amend, modify, supplement or otherwise
revise the provisions of the Joint Patent Agreement or (Y) sell, transfer, assign or release any of the ownership interests in the patents and patent applications (and all patents issued therefrom) listed on Schedule 3(o) or otherwise
subject to the Joint Patent Agreement, without the prior written consent of the holders of Notes and Warrants representing at least a majority of the number of shares of Common Stock issuable upon conversion or exercise of all of the Notes and
Warrants then outstanding (without regard to any limitations on conversion or exercise). 
 5. TRANSFER AGENT INSTRUCTIONS.

 The Company shall issue irrevocable instructions to its transfer agent in the form attached hereto as Exhibit K
(the “Irrevocable Transfer Agent Instructions”), and any subsequent transfer agent, to issue certificates or credit shares to the applicable balance accounts at the Depository Trust Company (“DTC”), registered in
the name of each Buyer or its respective nominee(s), for the Conversion Shares and the Warrant Shares in such amounts as specified from time to time by each Buyer to the Company upon conversion of the Notes or exercise of the Warrants. Prior to
registration of the Conversion Shares and the Warrant Shares under the 1933 Act, all such certificates shall bear the restrictive legend specified in Section 2(g). The Company warrants that no instruction other than the Irrevocable Transfer
Agent Instructions referred to in this Section 5 and stop transfer instructions to give effect to Section 2(f) (in the case of the Conversion Shares and the Warrant Shares, prior to registration of the Conversion Shares and the Warrant
Shares under the 1933 Act) will be given by the Company to its transfer agent and that the Securities shall otherwise be freely transferable on the books and records of the Company as and to the extent provided in this Agreement and the
Registration Rights Agreement. If a Buyer provides the Company with an opinion of counsel, in a generally acceptable form, to the effect that a public sale, assignment or transfer of the Securities may be made without registration under the
1933 Act or the Buyer provides the Company with reasonable assurance that the Securities can be sold pursuant to Rule 144 without any restriction as to the number of securities acquired as of a particular date that can then be immediately
sold, the Company shall permit the transfer and, in the case of the Conversion Shares and the Warrant Shares, promptly instruct its transfer agent to issue one or more certificates or credit shares to the applicable balance accounts at DTC in such
name and in such denominations as specified by such Buyer and without any restrictive legend. The Company acknowledges that a breach by it of its obligations hereunder will cause irreparable harm to the Buyers by vitiating the intent and purpose of
the transactions contemplated hereby. Accordingly, the Company acknowledges that the remedy at law for a breach of its obligations under this Section 5 will be inadequate and agrees, in the event of a breach or threatened breach by the Company
of the provisions of this Section 5, that the Buyers shall be entitled, in addition to all other available remedies, to an order 

  

 27 

 
and/or injunction restraining any breach and requiring immediate issuance and transfer, without the necessity of showing economic loss and without any bond
or other security being required. 
 6. CONDITIONS TO THE COMPANY’S OBLIGATION TO SELL. 
 a. Closing Date. The obligation of the Company to issue and sell the Notes and the Warrants to each Buyer at the Closing is subject
to the satisfaction, at or before the Closing Date, of each of the following conditions, provided that these conditions are for the Company’s sole benefit and may be waived by the Company at any time in its sole discretion by providing each
Buyer with prior written notice thereof: 
 (i) Such Buyer shall have executed each of the Transaction Documents to which it
is a party and delivered the same to the Company. 
 (ii) Such Buyer shall have delivered to the Company the Purchase Price
(less the amount withheld pursuant to Section 4(h)) for the Notes and the Warrants being purchased by such Buyer at the Closing by wire transfer of immediately available funds pursuant to the wire instructions provided by the Company.

 (iii) The representations and warranties of such Buyer shall be true and correct as of the date when made and as of the
Closing Date as though made at that time (except for representations and warranties that speak as of a specific date, which shall be true and correct as of such date), and such Buyer shall have performed, satisfied and complied with the covenants,
agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by such Buyer at or prior to the Closing Date. 
 7. CONDITIONS TO EACH BUYER’S OBLIGATION TO PURCHASE. 
 a. Closing Date.
The obligation of each Buyer hereunder to purchase the Notes and the Warrants from the Company at the Closing is subject to the satisfaction, at or before the Closing Date, of each of the following conditions, provided that these conditions are for
each Buyer’s sole benefit and may be waived only by such Buyer at any time in its sole discretion by providing the Company with prior written notice thereof: 
 (i) The Company shall have executed each of the Transaction Documents to which it is a party and delivered the same to such Buyer.

 (ii) The representations and warranties of the Company shall be true and correct as of the date when made and as of the
Closing Date as though made at that time (except for representations and warranties that speak as of a specific date, which shall be true and correct as of such date) and the Company shall have performed, satisfied and complied with the covenants,
agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by the Company at or prior to the Closing Date. Such Buyer shall have received a certificate, executed by the Chief Executive Officer of the
Company, dated as of the Closing Date, to the foregoing effect and as to such other matters as may be reasonably requested by such Buyer, including an update as of the Closing Date of the representations contained in Section 3(c) above.

  

 28 

 (iii) Such Buyer shall have received the opinion of Lord Bissell & Brook LLP
dated as of the Closing Date, which opinion will address, among other things, laws of the States of Nevada, New York and Delaware applicable to the transactions contemplated hereby and the security interests provided pursuant to the Security
Agreement, in form, scope and substance reasonably satisfactory to such Buyer and in substantially the form of Exhibit L attached hereto. 
 (iv) The Company shall have executed and delivered to such Buyer the Note Certificates and the Warrants (in such denominations as such Buyer shall request) for the Notes and the Warrants being purchased by such Buyer
at the Closing. 
 (v) The Board of Directors of the Company shall have adopted resolutions consistent with Section 3(b)
above and in a form reasonably acceptable to such Buyer (the “Resolutions”). 
 (vi) As of the Closing Date,
the Company shall have reserved out of its authorized and unissued Common Stock, solely for the purpose of effecting the conversion of the Notes and the exercise of the Warrants, at least 10,000,000 shares of Common Stock (such number to be adjusted
for any stock splits, stock dividends, stock combinations or other similar transactions involving the Common Stock that are effective at any time after the date of this Agreement). 
 (vii) The Irrevocable Transfer Agent Instructions shall have been delivered to and acknowledged in writing by the Company’s transfer
agent, and the Company shall have delivered a copy thereof to such Buyer. 
 (viii) The Company shall have delivered to such
Buyer a certificate evidencing the incorporation and good standing of the Company in Delaware issued by the Secretary of State (or other applicable authority) of Delaware as of a date within ten (10) days of the Closing Date. 
 (ix) The Company shall have delivered to such Buyer a secretary’s certificate, dated as of the Closing Date, certifying as to
(A) the Resolutions, (B) the Certificate of Incorporation of the Company, certified as of a date within ten (10) days of the Closing Date, by the Secretary of State of the State of Delaware, and (C) the Bylaws of the Company,
each as in effect at the Closing. 
 (x) The Company shall have made all filings under all applicable federal and state
securities laws necessary to consummate the issuance of the Securities pursuant to this Agreement in compliance with such laws. 
 (xi) The Company shall have delivered to such Buyer a letter from the Company’s transfer agent certifying the number of shares of Common Stock outstanding as of a date within five (5) days of the Closing Date. 
 (xii) The Company shall have delivered and pledged to such Buyer any and all Instruments, Negotiable Documents, Chattel Paper (each of the
foregoing terms, as 

  

 29 

 
defined in the Security Agreement) and certificated securities (accompanied by stock powers executed in blank), duly endorsed and/or accompanied by such
instruments of assignment and transfer executed by the Company in such form and substance as such Buyer may request. 
 (xiii)
The Company shall have given, executed, delivered, filed and/or recorded any financing statements, notices, instruments, documents, agreements and other papers that may be necessary or desirable (in the reasonable judgment of such Buyer) to create,
preserve, perfect or validate the security interest granted to such Buyer pursuant to the Security Agreement and to enable such Buyer to exercise and enforce its rights with respect to such security interest. 
 (xiv) The Company shall have delivered to such Buyer a landlord waiver and consent in the form attached as Exhibit M, with respect
to each of the leased Real Property. 
 (xv) The Company shall have delivered to such Buyer the Montano Guaranty, duly
executed by Montano. 
 (xvi) The Company shall not have made any public announcement regarding the transactions contemplated
by the Agreement prior to the Closing. 
 (xvii) The Company and its Subsidiaries shall have delivered to such Buyer such
other documents relating to the transactions contemplated by this Agreement as such Buyer or its counsel may reasonably request. 
 8.
INDEMNIFICATION. In consideration of each Buyer’s execution and delivery of the Transaction Documents and acquiring the Securities thereunder and in addition to all of the Company’s other obligations under the Transaction Documents,
the Company shall defend, protect, indemnify and hold harmless each Buyer and each other holder of the Securities and all of their stockholders, partners, officers, directors, members, managers, employees and direct or indirect investors and any of
the foregoing Persons’ agents or other representatives (including those retained in connection with the transactions contemplated by this Agreement) (collectively, the “Indemnitees”) from and against any and all actions, causes
of action, suits, claims, losses, costs, penalties, fees, liabilities and damages, and expenses in connection therewith (irrespective of whether any such Indemnitees is a party to the action for which indemnification hereunder is sought), and
including reasonable attorneys’ fees and disbursements (the “Indemnified Liabilities”), incurred by any Indemnitees as a result of, or arising out of, or relating to (a) any misrepresentation or breach of any
representation or warranty made by the Company in the Transaction Documents or any other certificate, instrument or document contemplated hereby or thereby, (b) any breach of any covenant, agreement or obligation of the Company contained in the
Transaction Documents or any other certificate, instrument or document contemplated hereby or thereby, (c) any cause of action, suit or claim brought or made against such Indemnitees and arising out of or resulting from the execution, delivery,
performance or enforcement of the Transaction Documents in accordance with the terms thereof or any other certificate, instrument or document contemplated hereby or thereby in accordance with the terms thereof (other than a cause of action, suit or
claim brought or made against an Indemnitee by such Indemnitee’s owners, investors or affiliates), or (d) any transaction financed or to be financed in whole or in 

  

 30 

 
part, directly or indirectly, with the proceeds of the issuance of the Securities. To the extent that the foregoing undertaking by the Company may be
unenforceable for any reason, the Company shall make the maximum contribution to the payment and satisfaction of each of the Indemnified Liabilities that is permissible under applicable law. Except as otherwise set forth herein, the mechanics and
procedures with respect to the rights and obligations under this Section 8 shall be the same as those set forth in Sections 6(a) and (d) of the Registration Rights Agreement, including those procedures with respect to the settlement
of claims and the Company’s rights to assume the defense of claims. 
 9. GOVERNING LAW; MISCELLANEOUS. 
 a. Governing Law; Jurisdiction; Jury Trial. All questions concerning the construction, validity, enforcement and interpretation of
this Agreement shall be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdiction) that would cause the
application of the laws of any jurisdiction other than the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, borough of Manhattan, for the
adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not
personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal
service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service shall constitute good and
sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. The Parties acknowledge that each of the Buyers has executed each of the
Transaction Documents to be executed by it in the State of New York and will have made the payment of the Purchase Price from its bank account located in the State of New York. EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE, AND AGREES
NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY. 
 b. Counterparts. This Agreement may be executed in two or more identical counterparts, all of which shall be considered one and the
same agreement and shall become effective when counterparts have been signed by each party and delivered to each other party; provided that a facsimile signature shall be considered due execution and shall be binding upon the signatory thereto with
the same force and effect as if the signature were an original, not a facsimile signature. 
 c. Headings. The headings
of this Agreement are for convenience of reference and shall not form part of, or affect the interpretation of, this Agreement. 
  

 31 

 d. Severability. If any provision of this Agreement shall be invalid or
unenforceable in any jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the validity or enforceability of any provision of this Agreement in
any other jurisdiction. 
 e. Entire Agreement; Amendments. This Agreement supersedes all other prior oral or written
agreements between each Buyer, the Company, their affiliates and Persons acting on their behalf with respect to the matters discussed herein, and this Agreement and the instruments referenced herein contain the entire understanding of the parties
with respect to the matters covered herein and therein and, except as specifically set forth herein or therein, neither the Company nor any Buyer makes any representation, warranty, covenant or undertaking with respect to such matters. No provision
of this Agreement may be waived, modified, supplemented or amended other than by an instrument in writing signed by the Company and the Buyers that purchased at least two-thirds (2/3) of the aggregate principal amount of the Notes on the
Closing Date, or if prior to the Closing, by the Buyers listed on the Schedule of Buyers as being obligated to purchase at least two-thirds (2/3) of the aggregate principal amount of the Notes. Any such amendment shall bind all holders
of the Notes and the Warrants. No such amendment shall be effective to the extent that it applies to less than all of the holders of the Notes or Warrants then outstanding. No consideration shall be offered or paid to any Person to amend or consent
to a waiver or modification or supplement of any provision of any of the Transaction Documents unless the same consideration also is offered to all of the parties to the Transaction Documents or holders of Notes, as the case may be. For
clarification purposes, this provision constitutes a separate right granted to each Buyer and is not intended for the Company to treat the Buyers as a class and shall not be construed in any way as the Buyers acting in concert or otherwise as a
group with respect to the purchase, disposition or voting of securities or otherwise. 
 f. Notices. Any notices,
consents, waivers or other communications required or permitted to be given under the terms of this Agreement must be in writing and will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt,
when sent by facsimile (provided confirmation of transmission is mechanically or electronically generated and kept on file by the sending party); or (iii) one (1) Business Day after deposit with a nationally recognized overnight delivery
service, in each case properly addressed to the party to receive the same. The addresses and facsimile numbers for such communications shall be: 
 If to the Company: 
 On or before March 31, 2006: 
 CardioVascular BioTherapeutics, Inc. 
 7251 W.
Lake Mead Blvd., Suite 300 
 Las Vegas, Nevada 89128 
 Facsimile: (702) 617-5651 
 Attention: Corporate Controller 
  

 32 

 After March 31, 2006: 
 CardioVascular BioTherapeutics, Inc. 
 1635
Village Center Circle, Suite 250 
 Las Vegas, Nevada 89134 
 Facsimile: (702) 617-5651 
 Attention: Corporate Controller 
 With copy to: 
 Lord Bissell & Brook
LLP 
 300 S. Grand Ave. 8th Floor 
 Los Angeles, CA 90071 
 Facsimile: (213) 485-1200 
 Attention: Ronald Warner, Esq. 
 If to the Transfer Agent: 
 American Stock
Transfer & Trust Company 
 6201 15th Avenue 
 Brooklyn, NY 11219 
 Telephone: (718) 921-8380 
 Facsimile:
(718) 765-8718 
 Attention: Barry S. Rosenthal 
 If to a Buyer, to it at the address and facsimile number set forth on the Schedule of Buyers, with copies to such Buyer’s representatives as set forth on the Schedule of Buyers, or, in the case of a Buyer or any other
party named above, at such other address and/or facsimile number and/or to the attention of such other Person as the recipient party has specified by written notice given to each other party five (5) days prior to the effectiveness of such
change. Written confirmation of receipt (A) given by the recipient of such notice, consent, waiver or other communication, (B) mechanically or electronically generated by the sender’s facsimile machine containing the time, date,
recipient facsimile number and an image of the first page of such transmission or (C) provided by a nationally recognized overnight delivery service shall be rebuttable evidence of personal service, receipt by facsimile or deposit with a
nationally recognized overnight delivery service in accordance with clause (i), (ii) or (iii) above, respectively. 
  

 33 

 g. Successors and Assigns. This Agreement shall be binding upon and inure to the
benefit of the parties and their respective successors and assigns, including any purchasers of the Notes. The Company shall not assign this Agreement or any rights or obligations hereunder without the prior written consent of the holders of at
least two-thirds (2/3) of the aggregate principal of the Notes then outstanding, including by merger or consolidation, except pursuant to a Change of Control (as defined in Section 4(b) of the Notes) with respect to which the Company is in
compliance with Section 4(l) of this Agreement, Section 4 of the Notes and Section 9 of the Warrants. A Buyer may assign some or all of its rights hereunder without the consent of the Company; provided, however, that any such
assignment shall not release such Buyer from its obligations hereunder unless such obligations are assumed by such assignee and the Company has consented to such assignment and assumption, which consent shall not be unreasonably withheld.
Notwithstanding anything to the contrary contained in the Transaction Documents, the Buyers shall be entitled to pledge the Securities in connection with a bona fide margin account or other loan or financing arrangement secured by the Securities.

 h. No Third Party Beneficiaries. This Agreement is intended for the benefit of the parties hereto and their
respective permitted successors and assigns and, to the extent provided in Section 8 hereof, each Indemnitee, and is not for the benefit of, nor may any provision hereof be enforced by, any other Person. 
 i. Survival. Unless this Agreement is terminated under Section 9(k), the representations and warranties of the Company and the
Buyers contained in Sections 2 and 3, the agreements and covenants set forth in Sections 4, 5 and 9, and the indemnification provisions set forth in Section 8, shall survive the Closing. Each Buyer shall be responsible only for its
own representations, warranties, agreements and covenants hereunder. 
 j. Further Assurances. Each party shall do and
perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents, as the other party may reasonably request in order to carry out the
intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby. 
 k.
Termination. In the event that the Closing shall not have occurred with respect to a Buyer on or before the third (3rd) Business Day following the date of this Agreement due to the Company’s or such Buyer’s failure to satisfy
the conditions set forth in Sections 6(a) and 7(a) above (and the nonbreaching party’s failure to waive such unsatisfied condition(s)), the nonbreaching party shall have the option to terminate this Agreement with respect to such breaching
party at the close of business on such date without liability of any party to any other party; provided, however, that if this Agreement is terminated pursuant to this Section 9(k), the Company shall be obligated to pay each of the Buyers (so
long as such Buyer is not a breaching party) its expense and commitment allowance as set forth in Section 4(h) as if such Buyer had purchased the principal amount of Notes set forth opposite its name on the Schedule of Buyers.

 l. Placement Agent. The Company acknowledges that it has engaged C.K. Cooper & Company as placement agent
in connection with the sale of the Notes and the related Warrants, which placement agent may have formally or informally engaged other agents on its 

  

 34 

 
behalf. The Company shall be responsible for the payment of any placement agent’s fees or broker’s commissions relating to or arising out of the
transactions contemplated hereby. The Company shall pay, and hold each Buyer harmless against, any liability, loss or expense (including attorneys’ fees and out-of-pocket expenses) arising in connection with any such claim. Each Buyer, with
respect to only itself, represents that it has not engaged a placement agent or broker in connection with the transactions contemplated hereby. 
 m. No Strict Construction. The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent, and no rules of strict construction will be applied against
any party. 
 n. Remedies. Each Buyer and each holder of the Securities shall have all rights and remedies set forth in
the Transaction Documents and all rights and remedies that such Buyers and holders have been granted at any time under any other agreement or contract and all of the rights that such Buyers and holders have under any law. Any Person having any
rights under any provision of this Agreement shall be entitled to enforce such rights specifically (without posting a bond or other security or proving actual damages), to recover damages by reason of any breach of any provision of this Agreement
and to exercise all other rights granted by law. 
 o. Payment Set Aside. To the extent that the Company makes a
payment or payments to the Buyers hereunder or pursuant to the Registration Rights Agreement, the Notes or Warrants or the Buyers enforce or exercise their rights hereunder or thereunder, and such payment or payments or the proceeds of such
enforcement or exercise or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside, recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to the Company, by a trustee,
receiver or any other Person under any law (including any bankruptcy law, state or federal law, common law or equitable cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied
shall be revived and continued in full force and effect as if such payment had not been made or such enforcement or setoff had not occurred. 
 p. Independent Nature of Buyers. The obligations of each Buyer hereunder are several and not joint with the obligations of any other Buyer, and no Buyer shall be responsible in any way for the performance of
the obligations of any other Buyer hereunder. Each Buyer shall be responsible only for its own representations, warranties, agreements and covenants hereunder. The decision of each Buyer to purchase the Securities pursuant to this Agreement has been
made by such Buyer independently of any other Buyer and independently of any information, materials, statements or opinions as to the business, affairs, operations, assets, properties, liabilities, results of operations, condition (financial or
otherwise) or prospects of the Company or any of its Subsidiaries which may have been made or given by any other Buyer or by any agent or employee of any other Buyer, and no Buyer or any of its agents or employees shall have any liability to any
other Buyer (or any other Person or entity) relating to or arising from any such information, materials, statements or opinions. Nothing contained herein, and no action taken by any Buyer pursuant hereto or thereto, shall be deemed to constitute the
Buyers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption 

  

 35 

 
that the Buyers are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated hereby. Each Buyer shall be
entitled to independently protect and enforce its rights, including the rights arising out of this Agreement the Notes or the Warrants, and it shall not be necessary for any other Buyer to be joined as an additional party in any proceeding for such
purpose. 
 q. Interpretative Matters. Unless the context otherwise requires, (a) all references to Sections,
Schedules or Exhibits are to Sections, Schedules or Exhibits contained in or attached to this Agreement, (b) each accounting term not otherwise defined in this Agreement has the meaning assigned to it in accordance with GAAP, (c) words in
the singular or plural include the singular and plural and pronouns stated in either the masculine, the feminine or neuter gender shall include the masculine, feminine and neuter and (d) the use of the word “including” in this
Agreement shall be by way of example rather than limitation. 
 * * * * * * 
  

 36 

 IN WITNESS WHEREOF, the Buyers and the Company have caused this Securities Purchase Agreement to
be duly executed as of the date first written above. 
  

									
	 COMPANY:
	 		 	 BUYERS:

			
	CARDIOVASCULAR BIOTHERAPEUTICS, INC.	 		 	HFTP INVESTMENT L.L.C.
					
		 		 		 	 By:
	 	 Promethean Asset Management L.L.C.

		 		 		 	 Its:
	 	 Investment Manager

		 		 		 		 	
	By:	 	 /s/ Mickael A. Flaa
	 		 	 By:
	 	 /s/ Robert J. Brantman

	Name:	 	 Mickael A. Flaa
	 		 	 Name:
	 	 Robert J. Brantman

	Title:	 	 Chief Financial Officer
	 		 	 Title:
	 	 Partner and Authorized Signatory

			
		 		 	GAIA OFFSHORE MASTER FUND, LTD.
					
		 		 		 	 By:
	 	 Promethean Asset Management L.L.C.

		 		 		 	 Its:
	 	 Investment Manager

					
		 		 		 	 By:
	 	 /s/ Robert J. Brantman

		 		 		 	 Name:
	 	 Robert J. Brantman

		 		 		 	 Title:
	 	 Partner and Authorized Signatory

			
		 		 	CAERUS FUND LTD.
					
		 		 		 	 By:
	 	 Promethean Asset Management L.L.C.

		 		 		 	 Its:
	 	 Investment Manager

					
		 		 		 	 By:
	 	 /s/ Robert J. Brantman

		 		 		 	 Name:
	 	 Robert J. Brantman

		 		 		 	 Title:
	 	 Partner and Authorized Signatory

  

 37 

					
	LEONARDO, L.P.
		
	By:	 	 Leonardo Capital Management, Inc.

	 Its:
	 	 General Partner

			
		 	 By:
	 	 Angelo, Gordon & Co., L.P.

		 	 Its:
	 	 Director

		
	 By:
	 	 /s/ Michael L. Gordon

	 Name:
	 	 Michael L. Gordon

	 Title:
	 	 Authorized Signatory

  

 38 

 SCHEDULE OF BUYERS 
  

											
	 Buyer’s Name
	  	 Buyer Address
 and Facsimile Number
	  	Principal Amount
of Notes	  	Reimbursement
Allocation
Percentage	 	 	 Investor’s Legal
 Representative’s
 Address and Facsimile
 Number

	HFTP Investment L.L.C.	  	 c/o Promethean Asset Management L.L.C.
 55 Fifth
Avenue
 17th
Floor
 New York, New York 10003
 Attention: Robert J.
Brantman
 Telephone: (212) 702-5200
 Facsimile: (212)
758-9620
 Residence: Delaware
	  	$	8,000,000	  	0.805	%	 	 Katten Muchin Rosenman LLP
 525 W. Monroe
Street
 Chicago, Illinois 60661-3693
 Attention: Mark D.
Wood
 Telephone: (312) 902-5200
 Facsimile: (312)
902-1061

					
	Gaia Offshore Master Fund, Ltd.	  	 c/o Promethean Asset Management L.L.C.
 55 Fifth
Avenue
 17th
Floor
 New York, New York 10003
 Attention: Robert J.
Brantman
 Telephone: (212) 702-5200
 Facsimile: (212)
758-9620
 Residence: Delaware
	  	$	5,200,000	  	0.085	%	 	 Katten Muchin Rosenman LLP
 525 W. Monroe
Street
 Chicago, Illinois 60661-3693
 Attention: Mark D.
Wood
 Telephone: (312) 902-5200
 Facsimile: (312)
902-1061

					
	Caerus Fund Ltd.	  	 c/o Promethean Asset Management L.L.C.
 55 Fifth
Avenue
 17th
Floor
 New York, New York 10003
 Attention: Robert J.
Brantman
 Telephone: (212) 702-5200
 Facsimile: (212)
758-9620
 Residence: Cayman Islands
	  	$	200,000	  	0.003	%	 	 Katten Muchin Rosenman LLP
 525 W. Monroe
Street
 Chicago, Illinois 60661-3693
 Attention: Mark D.
Wood
 Telephone: (312) 902-5200
 Facsimile: (312)
902-1061

					
	Leonardo, L.P.	  	 c/o Angelo, Gordon & Co. 245 Park Avenue
 New York,
New York 10167
 Attention: Gary I. Wolf
 Telephone: (212)
692-2058
 Facsimile: (212) 867-6449
 Residence:
	  	$	6,600,000	  	0.107	%	 	 Paul, Weiss, Rifkind, Wharton & Garrison LLP
 1285
Avenue of the Americas
 New York, New York 10019
 Attention:
Douglas A. Cifu
 Telephone: (212) 373-3000
 Facsimile: (212)
759-3990

 SCHEDULES 
  

			
	 Schedule 3(a)
	  	Organization and Qualification
	 Schedule 3(c)
	  	Capitalization
	 Schedule 3(f)
	  	SEC Documents; Financial Statements
	 Schedule 3(g)
	  	Absence of Certain Changes
	 Schedule 3(h)
	  	Litigation
	 Schedule 3(o)
	  	Intellectual Property Rights
	 Schedule 3(w)
	  	Transactions with Affiliates
	 Schedule 3(bb)
	  	Outstanding Indebtedness; Liens
	 Schedule 3(cc)
	  	Leases
	 Schedule 4(d)
	  	Use of Proceeds
	 Schedule 4(j)
	  	Affiliate Transaction Policy

 EXHIBITS 
  

			
	 Exhibit A
	  	Form of Note
	 Exhibit B
	  	Form of Initial Warrant
	 Exhibit C
	  	Form of Repurchase Warrant
	 Exhibit D
	  	Form of Registration Rights Agreement
	 Exhibit E
	  	Form of Security Agreement
	 Exhibit F
	  	Form of Patent Security Agreement
	 Exhibit G
	  	Form of Account Control Agreement
	 Exhibit H
	  	Form of Montano Guaranty
	 Exhibit I
	  	Form of Pledge Agreement
	 Exhibit J
	  	Form of Guaranty
	 Exhibit K
	  	Form of Irrevocable Transfer Agent Instructions
	 Exhibit L
	  	Form of Company Counsel Opinion
	 Exhibit M
	  	Form of Landlord Waiver and Consent

 CardioVascular BioTherapeutics Inc 
 Schedule 3(a) 
 Subsidiaries: 
  

	1.	The Company owns approximately 43% of Cardio Phage International (“CPI”) 

 Cardio owns 15,480,000 (43%) shares of common stock of CPI 
 CPI has a total of 40,000,000 shares
authorized and 36,000,000 have been issued. 
 CPI is an active trade or business with assets, liabilities and employees. 
  

	2.	CPI owns 70,000,000 (82.35%) shares of common stock of Cardio Phage Middle East (“CPME”) 

 CPME has a total of 100,000,000 shares authorized and 85,000,000 have been issued. 
 CPME is currently inactive as to business activity but is negotiating distribution agreements and potential financing. 
  

	3.	The Company owns approximately 4.5% of Phage Biotechnology Corporation (“Phage”) 

 Cardio owns 10,000,000 (4.5%) shares of common stock of Phage 
 Phage has a total of 400,000,000 shares authorized and 220,122,483 has been issued. 
 Phage is an active
trade or business with assets, liabilities and employees. 

 CardioVascular BioTherapeutics Inc 
 Schedule 3(c) 
  

					
	 Capitalization:
	  	 	  	 
	 Total common shares authorized
	  		  	400,000,000
		  		  	 
	 Shares issued at 2/28/06
	  		  	123,899,598
		  		  	 
	 Shares reserved for 2004 Stock Option Plan
	  		  	
	 Shares reserved for options issued from plan
	  	550,500	  	
	 Shares reserved for unissued options from 2004 Stock Option Plan
	  	4,449,500	  	
		  	 	  	
		  		  	5,000,000
		  		  	 
	 Warrants with Registration Rights
	  		  	
	 Warrants purchased by First Dunbar - *Piggyback Reg Rights on warrant shares
	  	75,000	  	
	 Warrant Exercise Price: $12.50/share
	  		  	
	 Issuance Date 2/15/2005
	  		  	
	 Expiration Date: 2/11/2010
	  		  	
	 Warrants issued to M. Flaa - Piggyback Reg Rights on warrant shares and warrant shares already registered
	  	200,000	  	
		  	 	  	
		  		  	275,000
		  		  	 
	 Warrant Exercise Price: $2.00/share
	  		  	
	 Issuance Date 6/23/2003
	  		  	
	 Expiration Date: 6/23/2013
	  		  	
	 Share reserved for issuance to consultants in the future
	  		  	1,000,000
	 Warrants awarded March 17, 2005 to Mickael A, Flaa - Piggyback Rights 250,000 @ $10
	  		  	250,000
	 Shares underlying options issued before adoption of the 2004 Stock Option Plan
	  		  	2,631,534
		  		  	 
	 Total outstanding options and warrants and reserved for future issuance
	  		  	4,156,534
		  		  	 

  

	*	Piggyback Registration Rights Defined: In the event the Company proposes to file a registration statement under the Securities Act of 1933 which relates to a current offering of
securities of the Company (except in connection with an offering on Form S-8 or S-4 or any other inappropriate form), such registration statement (and the prospectus included therein) shall also, at the written request to the Company by holder,
relate to and meet the requirements of the Act with respect to any public offering of this Warrant and Warrant Stock so as to permit the public sale of this Warrant and Warrant Stock. The Company shall give written notice to the Holder of its
intention to file a registration statement under the Act relating to a current offering of securities in the Company not less than thirty (30) days prior to the filing of such registration statement. 

 CardioVascular BioTherapeutics 
 Schedule 3(f) 
 SEC Documents (List of SEC Filings) 
  

							
	 Form
	  	 Description
	  	Filing Date	  	File Number
	 S-1
	  	 General form for registration of securities under the Securities Act of 1933
	  	9/23/04	  	333-119199
	 REGDEX
	  	 Registration of sale of securities [Regulation D and Section 4(6) of the Securities Act of 1933], Item 06
	  	10/14/04	  	021-70173
	 S-1/A
	  	 [Amend] General form for registration of securities under the Securities Act of 1933
	  	11/26/04	  	333-119199
	 S-1/A
	  	 [Amend] General form for registration of securities under the Securities Act of 1933
	  	1/13/05	  	333-119199
	 S-1/A
	  	 [Amend] General form for registration of securities under the Securities Act of 1933
	  	1/31/05	  	333-119199
	 S-1/A
	  	 [Amend] General form for registration of securities under the Securities Act of 1933
	  	2/4/05	  	333-119199
	 S-1/A
	  	 [Amend] General form for registration of securities under the Securities Act of 1933
	  	2/10/05	  	333-119199
	 424B4
	  	 Prospectus [Rule 424(b)(4)]
	  	2/15/05	  	333-119199
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/17/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/17/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/17/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/17/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/17/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/17/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/17/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/18/06	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/18/06	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/18/06	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/18/06	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/18/06	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/18/06	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/18/06	  	
	 8-A12G
	  	 Registration of Securities [Section 12(g)]
	  	2/22/05	  	000-51172
	 3
	  	 Initial statement of beneficial ownership of securities
	  	2/22/05	  	
	 SC 13D
	  	 General statement of acquisition of beneficial ownership
	  	2/22/05	  	005-80565
	 8-K
	  	 Current report, items 8.01 and 9.01
	  	3/15/05	  	000-51172
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	3/21/05	  	
	 424B3
	  	 Prospectus [Rule 424(b)(3)]
	  	3/24/05	  	333-119199
	 S-8
	  	 Securities to be offered to employees in employee benefit plans
	  	3/29/05	  	333-123641
	 10-K
	  	 Annual report [Section 13 and 15(d), not S-K Item 405]
	  	3/30/05	  	000-51172
	 PRE14A
	  	 Other preliminary proxy statements
	  	4/8/05	  	000-51172
	 DEF14A
	  	 Other preliminary proxy statements
	  	4/19/05	  	000-51172
	 8-K
	  	 Current report, items 2.02 and 9.01
	  	4/25/05	  	000-51172
	 8-K
	  	 Current Report, items 8301 and 9.01
	  	5/11/05	  	000-51172
	 10-Q
	  	 Quarterly Report [Sections 13 or 15(d)]
	  	5/12/05	  	000-51172
	 8-K
	  	 Current report, items 8.01 and 9.01
	  	6/10/05	  	000-51172
	 8-K
	  	 Current report, items 8.01 and 9.01
	  	6/10/05	  	000-51172
	 8-K
	  	 Current report, item 8.01
	  	6/21/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	7/19/05	  	

  

 3 of 11 

							
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	7/28/05	  	
	 10-Q
	  	 Quarterly Report [Sections 13 or 15(d)]
	  	8/11/05	  	000-51172
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/18/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/18/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/19/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/19/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/19/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/19/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/19/05	  	
	 4/A
	  	 [Amend] Statement of changes in beneficial ownership of securities
	  	8/19/05	  	
	 4/A
	  	 [Amend] Statement of changes in beneficial ownership of securities
	  	8/25/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/25/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	8/30/05	  	
	 3
	  	 Initial statement of beneficial ownership of securities
	  	8/30/05	  	
	 8-K
	  	 Current report, items 8.01 and 9.01
	  	9/13/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	9/23/05	  	000-51172
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	10/5/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	10/6/05	  	
	 10Q
	  	 Quarterly Report [Sections 13 or 15(d)]
	  	11/7/05	  	000-51172
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	11/17/05	  	
	 4
	  	 Statement of changes in beneficial ownership of securities
	  	12/23/05	  	
	     4/A    
	  	 [Amend] Statement of changes in beneficial ownership of securities
	  	12/23/05	  	
	 8-K
	  	 Current Report, items 8.01 and 9.01
	  	1/17/06	  	000-51172
	 8-K
	  	 Current Report, item 1.01
	  	3/9/06	  	000-51172

  

 4 of 11 

 CardioVascular BioTherapeutics Inc 
 Schedule 3(g) 
 Absence of Certain Changes 
 The company has paid or committed to expenditures of approximately $290,000 in tenant improvements, furniture and equipment for its new headquarters which to be occupied
starting in late March 2006. 
  

				
	A break-out of expense by category:	  		
	 Buildout
	  	$	150,000
	 Furniture and equipment
	  	 	100,000
		  	 	 
	 Total
	  	 	250,000
	Commitments not yet paid:	  		
	 Furniture and equipment
	  	 	40,000
		  	 	 

 Schedule 3(h) 
 Litigation 
  

											
	 Date Filed
	  	Case
Number	  	 Matter Name
	  	 Court
	  	 Description
	  	 Disposition

						
	31-Oct-05	  	A511084	  	DANIEL MONTANO vs. STEPHANIE HUGHES; STEPHANIE HUGHES vs. DANIEL MONTANO, an individual, CARDIOVASCULAR BIOTHERAPEUTICS, INC., a Nevada
Corporation	  	District Court, Clark County, Nevada	  	This matter began as a private action for Moneys Due and Owing commenced by Mr. Daniel Montano, as an individual, against Stephanie Hughes, an individual, to recover a personal loan of $33,000
he made to Ms. Hughes upon her request for assistance in paying personal obligations. Ms. Hughes has not repaid the loan. CardioVascular BioTherapeutics, Inc. (the “Company”) was not involved until the defendant (Stephanie Hughes) answered
the complaint with a Counterclaim naming the Company as a Counterdefendant, in an attempt to connect the plaintiff (Daniel Montano), as an individual, to the Company. The Company successfully demonstrated in a Motion to Dismiss that the Company was
not a proper party to the litigation and the Motion was granted, without prejudice, and thus the matter was dismissed as to the Company. Mr. Montano seeks a Motion for Summary Judgment in his favor so he may collect on the moneys owed to
him.	  	Motion to Dismiss granted to CARDIOVASCULAR BIOTHERAPEUTICS, INC.; January, 30 2006; Dismissed without prejudice

 Schedule 3(o): Intellectual Property Rights 
 Patent Rights: CardioVascular BioTherapeutics, Inc. 
 U.S. Patents 
  

							
	 HOLDER
	  	 PATENT
	  	PATENT
NUMBER	  	 ISSUE DATE

	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	6,268,178	  	July 31, 2001
				
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	6,794,162	  	September 21, 2004
				
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	6,773,899	  	August 10, 2004
				
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Method of Producing Biologically Active Human Acidic Fibroblast Growth Factor and its Use in Promoting Angiogenesis	  	6,642,026	  	November 4, 2003

  

 Page 1 of 9 

 Foreign Patents 
  

									
	 HOLDER
	  	COUNTRY	  	 PATENT
	  	PATENT
NUMBER	  	 ISSUE DATE

	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Austria	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Belgium	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Switzerland	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Germany	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	EP	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005

  

 Page 2 of 9 

									
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	France	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	United
Kingdom	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Ireland	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Liechtenstein	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	1180153	  	April 13, 2005

  

 Page 3 of 9 

 U.S. Patent Applications 
  

							
	 HOLDER
	  	 PATENT
	  	APPLICATION
NUMBER	  	 APPLICATION DATE

	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Method of Producing Biologically Active Human Acidic Fibroblast Growth Factor and its Use in Promoting Angiogenesis	  	10/649,480	  	August 27, 2003

 Foreign Patent Applications 
  

									
	 HOLDER
	  	COUNTRY	  	 PATENT
	  	APPLICATION
NUMBER	  	 APPLICATION DATE

	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Japan	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	2000 620108	  	May 24, 2000
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Australia	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	2001 284914	  	August 15, 2001
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Canada	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	2419203	  	August 15, 2001

  

 Page 4 of 9 

									
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Europe	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	01964014.3	  	August 15, 2001
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Japan	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	2002-519596	  	August 15, 2001
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Korea	  	Phage-Dependent Super-Production Of Biologically Active Protein And Peptides	  	2003-7002240	  	August 15, 2001
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Australia	  	Method of Producing Biologically Active Human Acidic Fibroblast Growth Factor and its Use in Promoting Angiogenesis	  	2001 288256	  	August 15, 2001
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Canada	  	Method of Producing Biologically Active Human Acidic Fibroblast Growth Factor and its Use in Promoting Angiogenesis	  	2419338	  	August 15, 2001

  

 Page 5 of 9 

									
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Europe	  	Method of Producing Biologically Active Human Acidic Fibroblast Growth Factor and its Use in Promoting Angiogenesis	  	01967977.8	  	August 15, 2001
					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Japan	  	Method of Producing Biologically Active Human Acidic Fibroblast Growth Factor and its Use in Promoting Angiogenesis	  	 2002-519599
	  	 August 15, 2001

					
	CardioVascular BioTherapeutics, Inc./Phage Biotechnology Corporation	  	Korea	  	Method of Producing Biologically Active Human Acidic Fibroblast Growth Factor and its Use in Promoting Angiogenesis	  	 2003-7002239
	  	 August 15, 2001

 Patent Licenses 
  

							
	 LICENSED
 PATENTS
	  	 NAME OF AGREEMENT
	  	PARTIES	  	 DATE OF AGREEMENT

	None

  

 Page 6 of 9 

 Schedule 3(o) : Trademarks: CardioVascular BioTherapeutics, Inc. 
  

													
	 KMOB
 Reference
 Number*
	  	Country	  	 Mark
	  	 Class(es) / Goods
	  	 App. No. /
 App. Date
	  	 Reg No. /
 Reg Date
	  	Status
	 CVBIO.009T
	  	U.S.	  	CARDIO VASCU-GROW	  	5: Pharmaceutical compositions for use in revascularization of the heart	  	78/163,385
9-12-02	  		  	Pending
							
	 CVBIO.009WAU
	  	Australia	  	CARDIO VASCU-GROW	  	5: Pharmaceutical, veterinary and sanitary preparations including; pharmaceutical compositions for use in revascularization of the heart	  	102091
9-16-04	  	1020901
5-18-05	  	Registered
							
	 CVBIO.009WCA
	  	Canada	  	CARDIO VASCU-GROW	  	5: Pharmaceutical compositions for use in revascularization of the heart	  	1231007
9-16-04	  		  	Pending
Published
							
	 CVBIO.005WEU
	  	European
Community	  	CARDIO VASCU-GROW	  	5: Pharmaceutical compositions for use in revascularization of the heart	  	1021658
12-21-98	  	1021658
3-17-00	  	Registered
							
	 CVBIO.005WJP
	  	Japan	  	CARDIO VASCU-GROW	  	5: Pharmaceutical compositions for use in revascularization of the heart	  	110528
12-24-98	  	4414864
9-8-00	  	Registered
							
	 CVBIO.009WLI
	  	Liechtenstein	  	CARDIO VASCU-GROW	  	5: Pharmaceutical compositions for use in revascularization of the heart	  	13362
9-22-04	  	136362
12-6-04	  	Registered
							
	 CVBIO.009WMX
	  	Mexico	  	CARDIO VASCU-GROW	  	5: Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressing;
materials for stopping teeth, dental wax, disinfectants; preparations for destroying vermin; fungicides, herbicides	  	0678039
9-22-04	  	865969
1-27-05	  	Registered
							
	 CVBIO.009WMC
	  	Monaco	  		  	5: Pharmaceutical compositions for use in revascularization of the heart	  	24747
9-22-04	  	0424307
11-30-04	  	Registered
							
	 CVBIO.009WNZ
	  	New Zealand	  	CARDIO VASCU-GROW	  	5: Pharmaceutical compositions for use in revascularization of the heart	  	718571
9-16-04	  	718571
3-17-05	  	Registered
							
	 CVBIO.009WCH
	  	Switzerland	  	CARDIO VASCU-GROW	  	5: Pharmaceutical compositions for use in revascularization of the heart	  	56235/2004
9-16-04	  	527625
11-11-04	  	Registered

  

 Page 7 of 9 

 Schedule 3(o): Trademarks: CardioVascular BioTherapeutics, Inc. (continued) 

 

													
	 KMOB
 Reference
 Number*
	  	Country	  	Mark	  	 Class(es) / Goods
	  	 App. No. /
 App. Date
	  	 Reg No. /
 Reg Date
	  	Status
	 CVBIO.006WEU
	  	European
Community	  	DR. STEGMANN
CARDIO-
REVASCULARIZATION	  	42: Medical services; medical clinics	  	1021591
12/21/98	  	1021591
3-17-00	  	Registered
							
	 CVBIO.003WEU
	  	European
Community	  	VASCU-FLOW	  	5: pharmaceutical compositions for use in revascularization of the heart	  	1023340
12-21-98	  	102340
3-17-00	  	Registered
							
	 CVBIO.004WEU
	  	European
Community	  	VASCU-GROW	  	5: Pharmaceutical compositions for use in growing new blood vessels	  	1021724
12-21-98	  	1021724
3-17-00	  	Registered
							
	 CVBIO.004WJP
	  	Japan	  	VASCU-GROW	  	5: Pharmaceutical compositions for use in growing new blood vessels	  	110527/1998
12-24-98	  	4414863
9-8-00	  	Registered

  

 Page 8 of 9 

 2443398 
 031506 

2444654 
 031506 
 2460753 
 032006 
  

 Page 9 of 9 

 CardioVascular BioTherapeutics Inc 
 Schedule 3(w) 
  

							
	 RELATED PARTY TRANSACTIONS
	  	Relation	  	FYE
2004	  	FYE
2005
	 Consulting Fees
	  		  		  	
	 Dr Thomas Stegmann
Co-Founder, Chief Clinical Officer
	  	D	  	259,250	  	587,300
	 Dr Wolfgang Preimer
Co-Founder
	  	D	  	42,000	  	55,500
	 Compensation
	  		  		  	
	 Dan Montano
Chief Executive Officer
	  	D O	  	321,769	  	431,538
	 Commissions and Investment banking fees
	  		  		  	
	 Alex Montano - et al (C&K Cooper)
Board of Directors Member
	  	D	  	5,000	  	20,000
	 Grant Gordon - GHL -et al
Board of Directors Member
	  	D	  	5,000	  	15,500
	 Phage Services
	  		  		  	
	 Phage Drug Development Support
	  	A	  	415,337	  	578,052
	 Phage Overhead Support
	  	A	  	148,507	  	263,922
		  		  	 	  	 
	 total
	  		  	563,844	  	841,973
		  		  	 	  	 
		  	D      Director	  	
		  	O      Officer	  	
		  	A      Affiliate	  	

 Significant Payments 
  

							
	 Party
	  	Date	  	2004	  	2005
	 Phage Biotechnology Corporation
	  	3/25/2005	  	0	  	600,000
	 To payoff intercompany balances
	  		  		  	
	 Dr. Thomas Stegmann
	  	2/28/2005	  	0	  	261,800
	 To pay deferred consulting fees
	  		  		  	

 Future Payments and other Agreements with Related Parties 
 C.K. Cooper - Engagement Agreement March 2, 2006 
 The Company
agrees to pay C.K. Cooper transaction fees equal to 6.0% of gross proceeds received from the sale of Securities in any transaction, payable upon transaction closing. The Company also agrees to pay a warrant exercise fees equal to 2.0% of any
proceeds received as a result of the exercise of warrants, payable within 10 days of receipt of funds by Company. The Company further agrees to reimburse C.K. Cooper upon request for out of pocket expenses for the aggregate amount of $50,000.

 Phage Biotechnology Corporation - Joint Patent Ownership August 16, 2004 
 The Company has a Joint Patent Ownership with Phage. Under this agreement, the Company and Phage, respectively, own an undivided one half interest in the U.S. and foreign patent rights necessary to develop and
commercialize Cardio Vascu-GrowTM. As a part of this agreement, the Company is obligated, at its option, to either (i) pay to Phage ten percent of net sales for Cardio Vascu-GrowTM manufactured for the Company by Phage or (ii) pay
to Phage a six percent royalty based on the Company’s net sales price of Cardio Vascu-GrowTM that Phage does not manufacture for the Company. This agreement expires on the last to expire of the patent rights covered, including extensions.

 Cardio Phage International, Inc. - Distribution Agreement August 16, 2004 
 The Company and Phage have entered into a distribution agreement with Cardio Phage International Inc. The Company and Phage each own 45% of the CPI outstanding stock and
the companies have the right to each appoint 45% of the CPI board. The Company has made no payments to CPI and does not anticipate making any payments in the near future. 
 Dr. Thomas Stegmann - Royalty Agreement August 30, 2004 
 The Company has entered into an agreement with
Dr. Stegmann, one of the Company’s directors and Chief Clinical Officer, whereby the Company will pay Dr. Stegmann a royalty of one percent of the Company’s net revenue (as defined) from commercial sales of Cardio
Vascu-GrowTM in exchange for rights granted to the Company to utilize the results of Dr. Stegmann’s
German clinical trials. This agreement terminates on December 31, 2013. Cardio has made no payments to Dr. Stegmann under this agreement. 
 Korea Biotechnology Development Co., Ltd. (“KBDC”) - Distribution Agreement December 15, 2000 
 The Company entered into an
agreement with Korea Biotechnology Development Co., Ltd. (“KBDC”) to commercialize the Company’s future products. The Company has transferred to KBDC the rights to manufacture and sell its products for 99 years in all of Korea, China,
and Taiwan. In exchange, KBDC arranged the purchase of 8,750,000 shares of the Company’s common stock for $3,602,000. KBDC agreed to fund all of the regulatory approval process in Korea for any products of the Company. In addition, KBDC agreed
to pay a royalty of 10% of net revenues to the Company. The royalties will be paid for the life of the agreement. Danial C Montano, an officer and director of CVBT, owns 17% of KDBC and Joong Ki Baik, a director of CVBT, owns 27% of KDBC.

  

	Guarantee:	 

 The Company guaranteed Phage’s
obligations under a non-cancelable operating lease for Theory laboratory and office space at University of California Irvine Research Center. The lease is for 11,091 rentable square feet for the period December 1, 2004 through August 31,
2006, and provides for a monthly rent of approximately $35,500 plus shared building operating expenses. 
 The Company guaranteed Phage’s
obligations under a Standard Industrial Net Lease for laboratory and office space. The lease is for 5,742 rentable square feet for the period March 10, 2006 through March 31, 2013 and provides for a monthly rent of approximately $16,700
plus shared building and operating expenses. Phage agrees to pay the Company 1/10 of 1% of the monthly lease payment per month on a monthly basis for the life of the guarantee. Furthermore, Phage agrees to indemnify the Company for Phage’s
activities for the duration of the guarantee. 
 Common Stock Ownership in Phage Biotechnology Corporation 
  

						
	 	  	 	  	%	 
	 Daniel C. Montano
	  	43,000,000	  	19.5	%
	 Alexander G. Montano
	  	13,140,000	  	6.0	%
	 Grant Gordon
	  	11,060,000	  	5.0	%
	 John (Jack) W. Jacobs, PhD
	  	650,000	  	0.3	%
	 Thomas L. Ingram
	  	1,000,000	  	0.5	%
	 Mickael A. Flaa
	  	50,000	  	0.0	%
	 Robert Levin
	  	200,000	  	0.1	%
	 All Directors and Executives
	  	69,100,000	  	31.4	%
		  	 	  	 	 
	 Total shares issued
	  	220,120,400	  	100.0	%

 CardioVascular BioTherapeutics Inc 
 Schedule 3(bb) 
 Outstanding Indebtedness and Liens 
 The Company has no outstanding Indebtedness or liens, except for the guarantees set forth on Schedule 3(w) and restrictions on the Business Performing Savings account of
Wells Fargo, A/C # 327-6310996, in the amount of $137,921.50 plus future accrued interest. This account contains blocked funds for purposes of securing Company credit cards. 
 The company maintains its accounts payable within 30 days and carries no balances with its vendors. At March 20th, 2006 the company had no accounts payable. 
 See schedule 3(w) for guarantees 

 CardioVascular BioTherapeutics Inc 
 Schedule 3(cc) 
 Real Property, Leases 
 The company has entered into a 5 year lease of an office facility located at 1635 Village Center Circle, Las Vegas NV, 89134, starting March 1, 2006. 
 The lease has a renewal provision for an additional 5 years 
 The 5 year
lease liability is $1,077,000. The lease obligation by year is as follows: 
  

			
	 2006
	  	169,000
	 2007
	  	208,000
	 2008
	  	214,000
	 2009
	  	221,000
	 2010
	  	227,000
	 2011
	  	38,000

 CardioVascular BioTherapeutics Inc 
 Schedule 4(d) 
 USE OF PROCEEDS: 
  

						
	 Source of Funds:
	  		  		
	 Gross Proceeds
	  		  	$	20,000,000
	 Transaction fees and expenses
	  		  		
	 Closing fee
	  	200,000	  		
	 Investment Banking fee
	  	1,200,000	  		
	 Other expenses
	  	50,000	  		
		  		  	 	1,450,000
		  		  	 	 
	 Net Proceeds
	  		  	 	18,550,000
			
	 Use of Proceeds:
	  		  		
	 Clinical Trials
	  		  	 	16,600,000
	 Working Capital
	  		  	 	1,950,000
		  		  	 	 
	 Total Uses of Proceeds
	  		  	$	18,550,000
		  		  	 	 

 Schedule 4(j) 
  

			
	

	  	7251 W. Lake Mead Blvd., Ste. 300
702 248 1174 TEL 702 617 5651 FAX
WWW.CVBT.COM

 CVBT Conflicts of Interest/Related Party Transactions Procedures 
 CVBT has adopted a Code of Conduct that meets the requirements of the Sarbanes-Oxley Act of 2002. Accordingly, any and all related party transactions are to be brought
to the attention of the Board of Directors. Our Corporate Governance Policy as overseen by our Corporate Governance Committee requires that related party transactions be reviewed and approved by the Conflicts Resolution Committee in advance of
entering into the transaction. The Conflicts Resolution Committee consists of members of our Board of Directors who are independent of the related party matter being decided. The Conflicts Resolution Committee is chaired by The Chairman of our Audit
Committee. This Committee decides the outcome of matters brought to its attention without the input or influence of executive officers or Board Members who are not independent of the related party matter being decided. The Committee Chair then
reports the conclusion of the Committee to the full Board of Directors along with an affirmative statement as to whether any input or influence was offered or attempted by executive officers or Board Members who are not independent of the related
party matter being decided. The decisions of the Conflicts Resolution Committee do not require ratification or approval by the full Board of Directors. 
 Additionally and as part of its Internal Audit Plan, the Audit Committee has engaged a National CPA firm to function as our outsourced Internal Audit Function. The adopted Audit Plan includes auditing 100% of related party transactions
every year. Our Audit Committee Chair and the Members of the Committee have strong legal, business and financial backgrounds and experience making this a very effective Audit Committee. I refer you to their resumes’ included in the attached
Proxy Statement. 
 In summary, our Code of Conduct prohibits Conflicts of Interest as a matter of Company Policy, except under “Guidelines”
approved by the Board of Directors. Those guidelines, as described above, include “Disclosure” to the Board of Directors, “Recusal” of the conflicted persons from any decision making regarding the transaction,
“Oversight” by the Audit Committee and “Third-Party Independent Review” annually by the Internal Auditors. Our adopted, implemented and functioning policies and processes for Conflicts of Interest meet the requirements of the
Sarbanes-Oxley Act of 2002 and the requirements of the major United States exchanges. 
 Dated December 14, 2005Registration Rights Agreement

 EXHIBIT 10.2 
 REGISTRATION RIGHTS AGREEMENT 
 REGISTRATION RIGHTS AGREEMENT (this
“Agreement”), dated as of March 20, 2006, by and among CardioVascular BioTherapeutics, Inc., a Delaware corporation, with headquarters currently located at 7251 West Lake Mead Boulevard, Suite 303, Las Vegas, Nevada 89128, to
be relocated to 1635 Village Center Circle, Suite 250, Las Vegas, Nevada 89134, effective April 1, 2006 (the “Company”), and the undersigned buyers (each, a “Buyer” and collectively, the
“Buyers”). 
 WHEREAS: 
 A. In connection with the Securities Purchase Agreement by and among the parties hereto of even date herewith (the “Securities Purchase Agreement”), the Company has agreed, upon the terms and subject
to the conditions of the Securities Purchase Agreement, to issue and sell at the Closing (as defined in the Securities Purchase Agreement) to the Buyers (i) convertible notes of the Company (including accrued and unpaid interest thereon and as
any of the same may be amended, restated or modified and in effect from time to time, the “Notes”), which will be convertible into shares of the Company’s common stock, $0.001 par value per share (the “Common
Stock”) in accordance with the terms of the Notes (the shares of Common Stock issuable upon conversion of the Notes being referred to as the “Conversion Shares”), and (ii) warrants to purchase shares of Common Stock
(any such warrants, as any of the same may be amended, restated or modified and in effect from time to time, the “Initial Warrants”; and the shares of Common Stock issuable upon exercise of the Initial Warrants being referred to
herein as the “Initial Warrant Shares”); 
 B. Pursuant to the terms of the Notes and subject to the conditions thereof, the
Company has agreed to issue to the Buyers additional warrants to purchase shares of Common Stock (any such additional warrants, as any of the same may be amended, restated or modified and in effect from time to time, the “Repurchase
Warrants”; and the shares of Common Stock issuable upon exercise of the Repurchase Warrants being referred to herein as “Repurchase Warrant Shares”); and 
 D. To induce the Buyers to execute and deliver the Securities Purchase Agreement, the Company has agreed to provide certain registration rights under the
Securities Act of 1933, as amended, and the rules and regulations thereunder, or any similar successor statute (collectively, the “1933 Act”), and applicable state securities laws. 

 NOW, THEREFORE, in consideration of the premises and the mutual covenants contained herein and
other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and each of the Buyers hereby agree as follows: 
 1. DEFINITIONS. 
 As used in this Agreement, the following terms shall have the following
meanings: 
 a. “Effectiveness Deadline” means the Initial Effectiveness Deadline, a Repurchase Warrant
Effectiveness Deadline, an Additional Effectiveness Deadline or an Additional Repurchase Warrant Effectiveness Deadline (each as defined below), as applicable. 
 b. “Filing Deadline” means the Initial Filing Deadline, a Repurchase Warrant Filing Deadline, an Additional Filing
Deadline, or an Additional Repurchase Warrant Filing Deadline (each as defined below), as applicable. 
 c. “Initial
Registrable Securities” means (i) the Conversion Shares issued or issuable upon conversion of the Notes (including any principal thereof or interest thereon), (ii) the Initial Warrant Shares issued or issuable upon exercise of the
Initial Warrants and (iii) any shares of capital stock issued or issuable with respect to the Conversion Shares, the Notes, the Initial Warrant Shares and the Initial Warrants as a result of any stock split, stock dividend, recapitalization,
exchange or similar event or otherwise, without regard to any limitations on conversions of Notes or exercises of Initial Warrants; provided, however, that any such Initial Registrable Securities shall cease to be Initial Registrable Securities when
a Registration Statement with respect to the sale of such securities becomes effective under the 1933 Act and such securities are disposed of in accordance with such Registration Statement, (b) such securities are sold in accordance with Rule
144 (as defined in Section 8) or (c) such securities become transferable without any restrictions in accordance with Rule 144(k) (or any successor provision). 
 d. “Initial Registration Statement” means a registration statement or registration statements of the Company filed under
the 1933 Act covering the Initial Registrable Securities. 
 e. “Investor” means a Buyer, any transferee or
assignee thereof to whom a Buyer assigns its rights under this Agreement and who agrees to become bound by the provisions of this Agreement in accordance with Section 9 and any transferee or assignee thereof to whom a transferee or assignee
assigns its rights under this Agreement and who agrees to become bound by the provisions of this Agreement in accordance with Section 9. 
 f. “Person” means an individual, a limited liability company, a partnership, a joint venture, a corporation, a trust, an unincorporated organization and a governmental or any department or agency
thereof. 
 g. “Register,” “registered,” and “registration” refer to a
registration effected by preparing and filing one or more Registration Statements (as defined below) in compliance with the 1933 Act and pursuant to Rule 415 under the 1933 Act or any successor rule providing for offering securities on a continuous
or delayed basis (“Rule 415”), and the declaration or ordering of effectiveness of such Registration Statement(s) by the United States Securities and Exchange Commission (the “SEC”). 
 h. “Registrable Securities” means the Initial Registrable Securities and the Repurchase Warrant Registrable Securities,
as applicable. 
  

 2 

 i. “Registration Statement” means the Initial Registration Statement,
and any Repurchase Warrant Registration Statement, as applicable. 
 j. “Repurchase Warrant Registrable
Securities” means all Repurchase Warrant Shares issued or issuable upon exercise of any Repurchase Warrants and (ii) any shares of capital stock issued or issuable with respect to the Repurchase Warrant Shares and the Repurchase
Warrants as a result of any stock split, stock dividend, recapitalization, exchange or similar event or otherwise, without regard to any limitations on the exercises of Repurchase Warrants; provided, however, that any such Repurchase Warrant
Registrable Securities shall cease to be Repurchase Warrant Registrable Securities when a Registration Statement with respect to the sale of such securities becomes effective under the 1933 Act and such securities are disposed of in accordance with
such Registration Statement, (b) such securities are sold in accordance with Rule 144 or (c) such securities become transferable without any restrictions in accordance with Rule 144(k) (or any successor provision). 
 k. “Repurchase Warrant Registration Statement” means a registration statement or registration statements of the Company
filed under the 1933 Act covering Repurchase Warrant Registrable Securities. 
 l. “Trading Day” means any
day on which the Common Stock is traded on the principal securities exchange or securities market on which the Common Stock is then traded; provided that “Trading Day” shall not include any day on which the Common Stock is scheduled to
trade, or actually trades, on such exchange or market for less than 4.5 hours. 
 m. “Warrants” means the
Initial Warrants and any Repurchase Warrants. 
 n. “Warrant Shares” means the Initial Warrant Shares and any
Repurchase Warrant Shares. 
 Capitalized terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Securities
Purchase Agreement. 
 2. REGISTRATION. 
 a. i. Initial Mandatory Registration. The Company shall prepare, and, as soon as practicable but in no event later than forty five (45) days after the Closing Date (the “Initial Filing
Deadline”), file with the SEC a Registration Statement on Form S-3, covering the resale of all of the Initial Registrable Securities. In the event that Form S-3 is unavailable for such a registration, the Company shall use such other form
as is available for such a registration, subject to the provisions of Section 2(d). The Initial Registration Statement prepared pursuant hereto shall register for resale at least that number of shares of Common Stock equal to the sum of
(x) 110% of the number of Initial Warrant Shares issuable upon exercise of all the outstanding Initial Warrants as of the second Trading Day immediately preceding the date the Initial Registration Statement is initially filed with the SEC and
(y) 175% of the greater of (A) $20,000,000 divided by the arithmetic average of the Weighted Average Price (as defined in the Notes) of the Common Stock on each of the five (5) consecutive Trading Days ending on the second Trading Day
immediately preceding the date the Initial Registration Statement is initially 

  

 3 

 
filed with the SEC and (B) the number of Conversion Shares issuable upon conversion of all the outstanding Notes as of the second Trading Day
immediately preceding the date the Initial Registration Statement is initially filed with the SEC, subject to adjustment as provided in Section 2(e). The calculations set forth in this paragraph shall be made without regard to any limitations
on the conversion of the Notes or exercise of the Warrants, and such calculations shall assume that the Notes and Warrants are then convertible and exercisable, respectively, into shares of Common Stock at the then prevailing Conversion Rate (as
defined in the Notes), and Warrant Exercise Price (as defined in the Initial Warrants), respectively. The Company shall use its best efforts to have the Initial Registration Statement declared effective by the SEC as soon as practicable, but in no
event later than the date which is one hundred twenty (120) days after the Closing Date (the “Initial Effectiveness Deadline”). 
 ii. Repurchase Warrant Mandatory Registration. The Company shall prepare, and, as soon as practicable but in no event later than ten (10) days after the issuance of each Repurchase Warrant (each, a
“Repurchase Warrant Filing Deadline”), file with the SEC a Registration Statement on Form S-3, covering the resale of all of the Repurchase Warrant Registrable Securities. In the event that Form S-3 is unavailable for such a
registration, the Company shall use such other form as is available for such a registration subject to the provisions of Section 2(d). Each Repurchase Warrant Registration Statement prepared pursuant hereto shall register for resale at least
that number of shares of Common Stock equal to 110% of the number of Repurchase Warrant Shares issuable upon the exercise of such Repurchase Warrant as of the second Trading Day immediately proceeding the date the Repurchase Warrant Registration
Statement is initially filed with the SEC, subject to adjustment as provided in Section 2(e). The calculation set forth in this paragraph shall be made without regard to any limitations on the exercise of the Repurchase Warrants, and such
calculation shall assume that the Repurchase Warrants are then exercisable into shares of Common Stock at the then prevailing Warrant Exercise Price (as defined in the Repurchase Warrants). The Company shall use its best efforts to have such
Repurchase Warrant Registration Statement declared effective by the SEC as soon as practicable, but in no event later than the date which is seventy-five (75) days after the issuance of such Repurchase Warrant (each, a “Repurchase
Warrant Effectiveness Deadline”). 
 b. Allocation of Registrable Securities. The initial number of
Registrable Securities included in any Registration Statement and each increase in the number of Registrable Securities included therein shall be allocated pro rata among the Investors based on the number of such Registrable Securities held by each
Investor at the time the Registration Statement covering such initial number of Registrable Securities or increase thereof is declared effective by the SEC. In the event that an Investor sells or otherwise transfers any of such Investor’s
Registrable Securities, each transferee shall be allocated a pro rata portion of the then remaining number of Registrable Securities included in such Registration Statement for such transferor. Any shares of Common Stock included in a Registration
Statement and which remain allocated to any Person which ceases to hold any Registrable Securities covered by such Registration Statement shall be allocated to the remaining Investors, pro rata based on the number of Registrable Securities then held
by such Investors which are covered by such Registration Statement. For purposes hereof, the number of Registrable Securities held by an Investor includes all Registrable Securities issuable upon the conversion of Notes and the exercise of 

  

 4 

 
Warrants held by such Investor, without regard to any limitations on conversion of the Notes or exercise of the Warrants. 
 c. Legal Counsel. Subject to Section 5 hereof, the Buyers holding securities representing at least two-thirds (2/3) of
the Registrable Securities shall have the right to select one legal counsel to review and oversee any offering pursuant to this Section 2 (“Legal Counsel”), which shall be Katten Muchin Rosenman LLP or such other counsel as
thereafter designated by the holders of securities representing at least two-thirds (2/3) of the Registrable Securities. The Company shall reasonably cooperate with Legal Counsel in performing the Company’s obligations under this
Agreement. 
 d. Ineligibility for Form S-3. In the event that Form S-3 is not available for the registration of the
resale of Registrable Securities hereunder, the Company shall undertake to register the Registrable Securities on Form S-3 as soon as such form is available, provided that the Company shall maintain the effectiveness of the Registration Statement
then in effect until such time as a Registration Statement on Form S-3 covering the Registrable Securities has been declared effective by the SEC. 
 e. Sufficient Number of Shares Registered. 
 i. In the event the number of shares
available under the Initial Registration Statement filed pursuant to Section 2(a)(i) is insufficient to cover all of the Initial Registrable Securities required to be covered by the Initial Registration Statement or an Investor’s allocated
portion of such Initial Registrable Securities pursuant to Section 2(b), the Company shall, as soon as practicable, but in any event not later than fifteen (15) days after the necessity therefor arises (the “Additional Filing
Deadline”), amend the Initial Registration Statement, or file a new Registration Statement (on the short form available therefor, if applicable), or both, so as to register for resale at least that number of shares of Common Stock equal to
the sum of (x) 110% of the number of Initial Warrant Shares issuable upon exercise of all the outstanding Initial Warrants as of the Trading Day immediately preceding the date of the filing of such amendment or new Registration Statement with
the SEC and (y) 175% of the greater of (A) the principal amount of the Notes then outstanding divided by the arithmetic average of the Weighted Average Price of the Common Stock on each of the five (5) consecutive Trading Days
immediately preceding the date of the filing of such amendment or new Registration Statement with the SEC and (B) the number of Conversion Shares issuable upon conversion of all the outstanding Notes, as of the Trading Day immediately preceding
the date of the filing of such amendment or new Registration Statement with the SEC. The Company shall use its best efforts to cause such amendment and/or new Registration Statement to become effective as soon as practicable following the filing
thereof, but in any event not later than seventy-five (75) days following the filing thereof (the “Additional Effectiveness Deadline”). For purposes of the foregoing provision, the number of shares available under the Initial
Registration Statement shall be deemed “insufficient to cover all of the Initial Registrable Securities” if as of any date of determination the number of shares of Common Stock equal to the sum of (x) 100% of the number of Initial
Warrant Shares issuable as of such time upon exercise of all the outstanding Initial Warrants and (y) 125% of the greater of (A) the principal amount of the Notes then outstanding divided by the arithmetic average of the Weighted Average
Price of the Common Stock on each of the ten (10) consecutive Trading Days immediately 

  

 5 

 
preceding such date of determination and (B) the number of Conversion Shares issuable upon conversion of all the outstanding Notes as of the Trading Day
immediately preceding such date of determination is greater than the number of shares of Common Stock available for resale under such Registration Statement. The calculations set forth in this paragraph shall be made without regard to any
limitations on the conversion of the Notes or exercise of the Initial Warrants, and such calculations shall assume that the Notes and the Initial Warrants are then convertible and exercisable, respectively, into shares of Common Stock at the then
prevailing Conversion Rate and Warrant Exercise Price (as defined in the Initial Warrants), respectively. 
 ii. In the event
the number of shares available under an Repurchase Warrant Registration Statement filed pursuant to Section 2(a)(ii) is insufficient to cover all of the Repurchase Warrant Registrable Securities required to be covered by the Repurchase Warrant
Registration Statement or an Investor’s allocated portion of such Repurchase Warrant Registrable Securities pursuant to Section 2(b), the Company shall, as soon as practicable, but in any event not later than fifteen (15) days after
the necessity therefor arises (an “Additional Repurchase Warrant Filing Deadline”), amend the Repurchase Warrant Registration Statement, or file a new Registration Statement (on the short form available therefor, if applicable), or
both, so as to register for resale at least that number of shares of Common Stock equal to 110% of the number of Repurchase Warrant Shares issuable upon exercise of all the Repurchase Warrants to which the Repurchase Warrant Registration Statement
relates as of the second Trading Day immediately preceding the date of the filing of such amendment or new Registration Statement with the SEC. The Company shall use its best efforts to cause such amendment and/or new Registration Statement to
become effective as soon as practicable following the filing thereof, but in any event not later than seventy-five (75) days following the filing thereof (an “Additional Repurchase Warrant Effectiveness Deadline”). For purposes
of the foregoing provision, the number of shares available under an Repurchase Warrant Registration Statement shall be deemed “insufficient to cover all of the Repurchase Warrant Registrable Securities” if as of any date of determination
the number of shares of Common Stock equal to 100% of the number of Repurchase Warrant Shares issuable as of such date of determination upon exercise of all the outstanding Repurchase Warrants to which the Repurchase Warrant Registration Statement
relates is greater than the number of shares of Common Stock available for resale under such Registration Statement. The calculations set forth in this paragraph shall be made without regard to any limitations on the exercise of the Repurchase
Warrants, and such calculations shall assume that the Warrants are then exercisable into shares of Common Stock at the then prevailing Warrant Exercise Price (as defined in the Repurchase Warrants). 
 f. Effect of Failure to File and Obtain and Maintain Effectiveness of Registration Statement. 
 i. If (i) a Registration Statement covering Initial Registrable Securities and required to be filed by the Company pursuant to
Section 2(a)(i) or Section 2(e)(i) of this Agreement is not (A) filed with the SEC on or before the applicable Filing Deadline or (B) declared effective by the SEC on or before the applicable Effectiveness Deadline or
(ii) on any day after a Registration Statement has been declared effective by the SEC sales of all the Initial Registrable Securities required to be included on such Registration Statement cannot be made (other than during an Allowable Grace
Period (as defined in Section 3(t))) pursuant to such 

  

 6 

 
Registration Statement (including because of a failure to keep the such Registration Statement effective, to disclose such information as is necessary for
sales to be made pursuant to such Registration Statement or to register sufficient shares of Common Stock, as determined in accordance with Section 2(e)), then, as partial relief for the damages to any holder of Notes or Initial Warrants by
reason of any such delay in or reduction of its ability to sell the underlying shares of Common Stock (which remedy shall not be exclusive of any other remedies available at law or in equity), the Company shall pay to such holder an amount in cash
equal to the product of (i) the sum of (A) the principal amount of the Notes held by such holder and (B) the total Aggregate Exercise Price (as defined in the Initial Warrants) of all Initial Warrants held by such holder, multiplied
by (ii) the sum of (A) 0.02, if such Registration Statement is not filed by the applicable Filing Deadline, plus (B) 0.02, if such Registration Statement is not declared effective by the applicable Effectiveness Deadline, plus
(C) the product of (I) 0.000667 multiplied by (II) the sum (without duplication) of (x) the number of days after the applicable Filing Deadline that such Registration Statement is not filed with the SEC, plus (y) the number of
days after the applicable Effectiveness Deadline that such Registration Statement is not declared effective by the SEC, plus (z) the number of days after such Registration Statement has been declared effective by the SEC that such Registration
Statement is not available (other than during an Allowable Grace Period) for the sale of at least all the Initial Registrable Securities required to be included on such Registration Statement pursuant to Section 2(e)(i). 
 ii. If (i) a Registration Statement covering all the Repurchase Warrant Registrable Securities and required to be filed by the
Company pursuant to Section 2(a)(ii) or Section 2(e)(ii) of this Agreement is not (A) filed with the SEC on or before the applicable Filing Deadline or (B) declared effective by the SEC on or before the applicable Effectiveness
Deadline or (ii) on any day after such Registration Statement has been declared effective by the SEC sales of all the Repurchase Warrant Registrable Securities required to be included on such Registration Statement cannot be made (other than
during an Allowable Grace Period) pursuant to such Registration Statement (including because of a failure to keep such Registration Statement effective, to disclose such information as is necessary for sales to be made pursuant to such Registration
Statement or to register sufficient shares of Common Stock, as determined in accordance with Section 2(e)), then, as partial relief for the damages to any holder of Repurchase Warrants by reason of any such delay in or reduction of its ability
to sell the underlying shares of Common Stock (which remedy shall not be exclusive of any other remedies available at law or in equity), the Company shall pay to such holder an amount in cash equal to the product of (i) the total Aggregate
Exercise Price (as defined in the Repurchase Warrants) of all Repurchase Warrants held by such holder and to which such Registration Statement relates, multiplied by (ii) the sum of (A) 0.02, if such Registration Statement is not filed by
the applicable Filing Deadline, plus (B) 0.02, if such Registration Statement is not declared effective by the applicable Effectiveness Deadline, plus (C) the product of (I) 0.000667 multiplied by (II) the sum (without duplication) of
(x) the number of days after the applicable Filing Deadline that such Registration Statement is not filed with the SEC, plus (y) the number of days after the applicable Effectiveness Deadline that such Registration Statement is not
declared effective by the SEC, plus (z) the number of days after such Registration Statement has been declared effective by the SEC that such Registration Statement is not available (other than during an Allowable Grace Period) for the sale of
at least all the Repurchase Warrant Registrable Securities required to be included on such Registration Statement pursuant to Section 2(e)(ii). 
  

 7 

 iii. The payments to which a holder shall be entitled pursuant to this Section 2(f)
are referred to herein as “Registration Delay Payments.” Registration Delay Payments shall be paid on the earlier of (I) the last day of the calendar month during which such Registration Delay Payments are incurred and (II) the
third Business Day after the event or failure giving rise to the Registration Delay Payments is cured. In the event the Company fails to make Registration Delay Payments in a timely manner, such Registration Delay Payments shall bear interest at the
rate of the lesser of 2.0% per month (prorated for partial months) or the highest lawful interest rate, in each case, until paid in full. 
 3. RELATED OBLIGATIONS. 
 At such time as the Company is obligated to file a Registration Statement with the
SEC pursuant to Section 2(a) or 2(e), the Company will use its best efforts to effect the registration of the Registrable Securities in accordance with the intended method of disposition thereof and, pursuant thereto, the Company shall have the
following obligations: 
 a. The Company shall promptly prepare and file with the SEC a Registration Statement with respect to
the applicable Registrable Securities (but in no event later than the applicable Filing Deadline) and use its best efforts to cause such Registration Statement relating to the Registrable Securities to become effective as soon as practicable after
such filing (but in no event later than the applicable Effectiveness Deadline). No later than the first Business Day after such Registration Statement becomes effective, the Company will file with the SEC the final prospectus included therein
pursuant to Rule 424 (or successor thereto) promulgated under the 1933 Act. The Company shall keep each Registration Statement effective pursuant to Rule 415 at all times until the earlier of (i) the date as of which the Investors may sell all
of the Registrable Securities covered by such Registration Statement without restriction pursuant to Rule 144(k) (or successor thereto) promulgated under the 1933 Act or (ii) the date on which the Investors shall have sold all the Registrable
Securities covered by such Registration Statement (the “Registration Period”). Such Registration Statement (including any amendments or supplements thereto and any prospectuses (preliminary, final, summary or free writing) contained
therein or related thereto shall not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein, or necessary to make the statements therein, in light of the circumstances in which they were made,
not misleading. The term “best efforts” shall mean, among other things, that the Company shall submit to the SEC, within two (2) Business Days after the Company learns that no review of a particular Registration Statement will be made
by the staff of the SEC or that the staff has no further comments on the Registration Statement, as the case may be, a request for acceleration of effectiveness of such Registration Statement to a time and date not later than 48 hours after the
submission of such request. 
 b. The Company shall prepare and file with the SEC such amendments (including post-effective
amendments) and supplements to a Registration Statement and the prospectus used in connection with such Registration Statement, which prospectus is to be filed pursuant to Rule 424 promulgated under the 1933 Act, as may be necessary to keep such
Registration Statement effective at all times during the Registration Period, and, during such period, comply with the provisions of the 1933 Act with respect to the disposition of all Registrable Securities of the Company covered by such
Registration Statement until such time as 

  

 8 

 
all of such Registrable Securities shall have been disposed of in accordance with the intended methods of disposition by the seller or sellers thereof as set
forth in such Registration Statement. 
 c. The Company shall (A) permit Legal Counsel to review and comment upon
(i) the Initial Registration Statement at least five (5) Business Days prior to its filing with the SEC, and (ii) all other Registration Statements and all amendments and supplements to all Registration Statements (except for Annual
Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K and any similar or successor reports) within a reasonable number of days prior to their filing with the SEC, and (B) not file any document, registration
statement, amendment or supplement described in the foregoing clause (A) in a form to which Legal Counsel reasonably objects. The Company shall not submit a request for acceleration of the effectiveness of a Registration Statement or any
amendment or supplement thereto without providing prior notice thereof to Legal Counsel and each Investor. The Company shall furnish to Legal Counsel, without charge, (i) promptly after the same is prepared and filed with the SEC, one copy of
any Registration Statement and any amendment(s) thereto, including financial statements and schedules, all documents incorporated therein by reference, and all exhibits and (ii) upon the effectiveness of any Registration Statement, one copy of
the prospectus included in such Registration Statement and all amendments and supplements thereto. The Company shall reasonably cooperate with Legal Counsel in performing the Company’s obligations pursuant to this Section 3. 
 d. The Company shall furnish to each Investor whose Registrable Securities are included in any Registration Statement, without charge,
(i) promptly after the same is prepared and filed with the SEC, at least one copy of such Registration Statement and any amendment(s) thereto, including financial statements and schedules, all documents incorporated therein by reference that
have not been filed via EDGAR, all exhibits and each preliminary prospectus, (ii) upon the effectiveness of any Registration Statement, at least one copy of the prospectus included in such Registration Statement and all amendments and
supplements thereto and (iii) such other documents, including copies of any prospectus (preliminary, final, summary or free writing), as such Investor may reasonably request from time to time in order to facilitate the disposition of the
Registrable Securities owned by such Investor. 
 e. The Company shall use its best efforts to (i) register and qualify,
unless an exemption from registration and qualification applies, the resale by the Investors of the Registrable Securities covered by a Registration Statement under the securities or “blue sky” laws of all the states of the United States,
(ii) prepare and file in those jurisdictions, such amendments (including post-effective amendments) and supplements to such registrations and qualifications as may be necessary to maintain the effectiveness thereof during the Registration
Period, (iii) take such other actions as may be necessary to maintain such registrations and qualifications in effect at all times during the Registration Period, and (iv) take all other actions reasonably necessary or advisable to qualify
the Registrable Securities for sale in such jurisdictions; provided, however, that the Company shall not be required in connection therewith or as a condition thereto to (x) qualify to do business in any jurisdiction where it would not
otherwise be required to qualify but for this Section 3(e) or (y) subject itself to general taxation in any such jurisdiction. The Company shall promptly notify Legal Counsel and each Investor who holds Registrable Securities of the
receipt by the Company of any notification with respect to the suspension of the registration or qualification of any of the Registrable Securities for sale 

  

 9 

 
under the securities or “blue sky” laws of any jurisdiction in the United States or its receipt of actual notice of the initiation or threatening
of any proceeding for such purpose. 
 f. The Company shall notify Legal Counsel and each Investor in writing of the happening
of any event, as promptly as practicable after becoming aware of such event, as a result of which the prospectus included in a Registration Statement, as then in effect, includes an untrue statement of a material fact or omission to state a material
fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading (provided that in no event shall such notice contain any material, nonpublic information), and
promptly prepare and file with the SEC a supplement or amendment to such Registration Statement to correct such untrue statement or omission, and deliver at least one copy of such supplement or amendment to Legal Counsel and each Investor. The
Company shall also promptly notify Legal Counsel and each Investor in writing (i) when a prospectus or any prospectus supplement or post-effective amendment has been filed, and when a Registration Statement or any post-effective amendment has
become effective (notification of such effectiveness shall be delivered to Legal Counsel and each Investor by facsimile on the same day of such effectiveness and by overnight mail), (ii) of any request by the SEC for amendments or supplements
to a Registration Statement or related prospectus or related information, and (iii) of the Company’s reasonable determination that a post-effective amendment to a Registration Statement would be appropriate. 
 g. The Company shall use its best efforts to prevent the issuance of any stop order or other suspension of effectiveness of a Registration
Statement, or the suspension of the qualification of any of the Registrable Securities for sale in any jurisdiction and, if such an order or suspension is issued, to obtain the withdrawal of such order or suspension at the earliest possible moment
and to notify Legal Counsel and each Investor who holds Registrable Securities being sold of the issuance of such order and the resolution thereof or its receipt of actual notice of the initiation or threat of any proceeding for such purpose.

 h. At the reasonable request (in the context of the securities laws) of any Investor, the Company shall furnish to such
Investor, on the date of the effectiveness of the Registration Statement and thereafter from time to time on such dates as an Investor may reasonably request (i) a letter, dated such date, from the Company’s independent certified public
accountants in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering, addressed to the Investors, and (ii) an opinion, dated as of such date, of counsel
representing the Company for purposes of such Registration Statement, in form, scope and substance as is customarily given in an underwritten public offering, addressed to the Investors. 
 i. At the reasonable request (in the context of the securities laws) of any Investor, the Company shall make available for inspection
during regular business hours by (i) any Investor, (ii) Legal Counsel and (iii) one firm of accountants or other agents retained by the Investors (collectively, the “Inspectors”), all pertinent financial and other
records, and pertinent corporate documents and properties of the Company (collectively, the “Records”), as shall be reasonably deemed necessary by each Inspector, and cause the Company’s officers, directors and employees to
supply all information which any Inspector may reasonably request; provided, however, that each Inspector shall agree to hold in strict confidence and shall not make 

  

 10 

 
any disclosure (except to an Investor) or use of any Record or other information which the Company determines in good faith to be confidential, and of which
determination the Inspectors are so notified, unless (a) the disclosure of such Records is necessary to avoid or correct a misstatement or omission in any Registration Statement or is otherwise required under the 1933 Act, (b) the release
of such Records is ordered pursuant to a final, non-appealable subpoena or order from a court or government body of competent jurisdiction, or (c) the information in such Records has been made generally available to the public other than by
disclosure in violation of this or any other agreement of which the Inspector has knowledge. Each Investor agrees that it shall, upon learning that disclosure of such Records is sought in or by a court or governmental body of competent jurisdiction
or through other means, give prompt notice to the Company and allow the Company, at its expense, to undertake appropriate action to prevent disclosure of, or to obtain a protective order for, the Records deemed confidential. Each Inspector which
exercises its rights under this Section 3(i) shall be obligated to execute a non-disclosure agreement containing such reasonable terms as the Company may request. The fees and expenses of the Inspectors shall be borne by the applicable
Investor. 
 j. The Company shall hold in confidence and not make any disclosure of information concerning an Investor
provided to the Company unless (i) disclosure of such information is necessary to comply with federal or state securities laws, (ii) the disclosure of such information is necessary to avoid or correct a misstatement or omission in any
Registration Statement, (iii) the release of such information is ordered pursuant to a subpoena or other final, non-appealable order from a court or governmental body of competent jurisdiction, or (iv) such information has been made
generally available to the public other than by disclosure in violation of this Agreement or any other agreement. The Company agrees that it shall, upon learning that disclosure of such information concerning an Investor is sought in or by a court
or governmental body of competent jurisdiction or through other means, give prompt written notice to such Investor and allow such Investor, at the Investor’s expense, to undertake appropriate action to prevent disclosure of, or to obtain a
protective order for, such information. 
 k. The Company shall use its best efforts to (i) remain eligible for quotation
of its securities on OTC Bulletin Board and to cause all of the Registrable Securities covered by a Registration Statement to be quoted thereon, so long as such Registrable Securities are not listed on a registered national securities exchange, the
NASDAQ National Market (or successor thereto) or the NASDAQ Capital Market, (ii) cause all the Registrable Securities covered by a Registration Statement to be listed on each securities exchange or trading market on which securities of the same
class or series issued by the Company are listed, and (iii) without limiting the generality of the foregoing, arrange for at least two market makers to register with the National Association of Securities Dealers, Inc. (“NASD”)
as such with respect to such Registrable Securities. The Company shall pay all fees and expenses in connection with satisfying its obligation under this Section 3(k). 
 l. The Company shall cooperate with the Investors who hold Registrable Securities being offered and, to the extent applicable, facilitate
the timely preparation and delivery of certificates (not bearing any restrictive legend) representing the Registrable Securities to be offered pursuant to a Registration Statement and enable such certificates to be in such denominations or amounts,
as the case may be, as the Investors may reasonably request and registered in such names as the Investors may request. 
  

 11 

 m. The Company shall provide a transfer agent and registrar of all such Registrable
Securities not later than the effective date of the applicable Registration Statement. 
 n. If requested by an Investor, the
Company shall (i) as soon as practicable incorporate in a prospectus supplement or post-effective amendment such information as an Investor requests to be included therein relating to the sale and distribution of Registrable Securities,
including information with respect to the number of Registrable Securities being offered or sold, the purchase price being paid therefor and any other terms of the offering of the Registrable Securities to be sold in such offering; (ii) as soon
as practicable make all required filings of such prospectus supplement or post-effective amendment after being notified of the matters to be incorporated in such prospectus supplement or post-effective amendment; and (iii) as soon as
practicable, supplement or make amendments to any Registration Statement if reasonably requested by an Investor of such Registrable Securities. 
 o. The Company shall use its best efforts to cause the Registrable Securities covered by the applicable Registration Statement to be registered with or approved by such other governmental agencies or authorities in
the United States as may be necessary to consummate the disposition of such Registrable Securities. 
 p. The Company shall
make generally available to its security holders as soon as practical, but not later than ninety (90) days after the close of the period covered thereby, an earnings statement (in form complying with the provisions of Rule 158 under the 1933
Act) covering a twelve (12)-month period beginning not later than the first day of the Company’s fiscal quarter next following the effective date of a Registration Statement. 
 q. The Company shall otherwise use its best efforts to comply with all applicable rules and regulations of the SEC in connection with any
registration hereunder. 
 r. Within two (2) Business Days after a Registration Statement which covers applicable
Registrable Securities is ordered effective by the SEC, the Company shall deliver, and shall cause legal counsel for the Company to deliver, to the transfer agent for such Registrable Securities (with copies to the Investors whose Registrable
Securities are included in such Registration Statement) confirmation that such Registration Statement has been declared effective by the SEC in substantially the form attached hereto as Exhibit A, provided that if the Company changes its
transfer agent, it shall immediately deliver any previously delivered notices under this Section 3(r) and any subsequent notices to such new transfer agent. 
 s. The Company shall make such filings with the NASD (including providing all required information and paying required fees thereto) as
and when reasonably requested by any Investors and make all other filings and take all other actions reasonably necessary to expedite and facilitate disposition by the Investors of Registrable Securities pursuant to a Registration Statement,
including responding to any comments received from the NASD within five Trading Days. 
 t. Notwithstanding anything to the
contrary in Section 3(f), at any time after the applicable Registration Statement has been declared effective by the SEC, the Company may delay the disclosure of material non-public information concerning the Company the disclosure 

  

 12 

 
of which at the time is not, in the good faith opinion of the Board of Directors of the Company and its counsel, in the best interest of the Company and, in
the opinion of counsel to the Company, otherwise required (a “Grace Period”); provided, that the Company shall promptly (i) notify the Investors in writing of the existence of material non-public information giving rise to a
Grace Period (provided that in each notice the Company shall not disclose the content of such material non-public information to the Investors) and the date on which the Grace Period will begin, and (ii) notify the Investors in writing of the
date on which the Grace Period ends; and, provided further, that (A) no Grace Period shall exceed fifteen (15) consecutive days, (B) during any 365 day period such Grace Periods shall not exceed an aggregate of thirty (30) days
and (C) the first day of any Grace Period must be at least two (2) Trading Days after the last day of any prior Grace Period (a Grace Period that satisfies all of the requirements of this Section 3(t) being referred to as an
“Allowable Grace Period”). For purposes of determining the length of a Grace Period above, the Grace Period shall begin on and include the date the holders receive the notice referred to in clause (i) and shall end on and
include the later of the date the holders receive the notice referred to in clause (ii) and the date referred to in such notice. The provisions of Section 3(f) hereof shall not be applicable during the period of any Allowable Grace Period.
Upon expiration of the Grace Period, the Company shall again be bound by the provisions of Section 3(f) with respect to the information giving rise thereto unless such material non-public information is no longer applicable. 
 4. OBLIGATIONS OF THE INVESTORS. 
 a. At least seven (7) Business Days prior to the first anticipated filing date of a Registration Statement and at lease five (5) Business Days prior to the filing of any amendment or supplement to a
Registration Statement, the Company shall notify each Investor in writing of the information, if any, the Company requires from each such Investor if such Investor elects to have any of such Investor’s Registrable Securities included in such
Registration Statement or, with respect to an amendment or a supplement, if such Investor’s Registrable Securities are included in such Registration Statement (each an “Information Request”). Provided that the Company shall
have complied with its obligations set forth in the preceding sentence, it shall be a condition precedent to the obligations of the Company to complete the registration pursuant to this Agreement with respect to the Registrable Securities of a
particular Investor that such Investor shall furnish to the Company, in response to an Information Request, such information regarding itself, the Registrable Securities held by it and the intended method of disposition of the Registrable Securities
held by it as shall be reasonably required to effect the registration of such Registrable Securities and shall execute such documents in connection with such registration as the Company may reasonably request. 
 b. Each Investor, by such Investor’s acceptance of the Registrable Securities, agrees to cooperate with the Company as reasonably
requested by the Company in connection with the preparation and filing of any Registration Statement hereunder, unless such Investor has notified the Company in writing of such Investor’s election to exclude all of such Investor’s
Registrable Securities from such Registration Statement. 
 c. Each Investor agrees that, upon receipt of any notice from the
Company of the happening of any event of the kind described in Section 3(g) or the first sentence of 3(f) or written notice from the Company of an Allowable Grace Period, such Investor will immediately 

  

 13 

 
discontinue disposition of Registrable Securities pursuant to any Registration Statement(s) covering such Registrable Securities until such Investor’s
receipt of the copies of the supplemented or amended prospectus contemplated by Section 3(g) or the first sentence of 3(f) or receipt of notice that no supplement or amendment is required or that the Allowable Grace Period has ended.
Notwithstanding anything to the contrary, the Company shall cause its transfer agent to deliver unlegended shares of Common Stock to a transferee of an Investor in accordance with the terms of the Securities Purchase Agreement in connection with any
sale of Registrable Securities with respect to which an Investor has entered into a contract for sale prior to the Investor’s receipt of a notice from the Company of the happening of any event of the kind described in Section 3(g) or the
first sentence of 3(f) and for which the Investor has not yet settled. 
 5. EXPENSES OF REGISTRATION. 
 All reasonable expenses, other than underwriting discounts and commissions, incurred in connection with registrations, filings or
qualifications pursuant to Sections 2 and 3, including all registration, listing and qualifications fees, printers and accounting fees, and fees and disbursements of counsel for the Company shall be paid by the Company. The Company shall also
reimburse the Investors for the reasonable fees and disbursements of Legal Counsel in connection with registration, filing or qualification pursuant to Sections 2 and 3 of this Agreement. 
 6. INDEMNIFICATION. 
 In the event any Registrable Securities are included in a Registration Statement under this Agreement: 
 a. To the
fullest extent permitted by law, the Company will, and hereby does, indemnify, hold harmless and defend each Investor, the directors, officers, partners, members, managers, employees, agents, representatives of, and each Person, if any, who controls
any Investor within the meaning of the 1933 Act or the 1934 Act (each, an “Indemnified Person”), against any losses, claims, damages, liabilities, judgments, fines, penalties, charges, costs, reasonable attorneys’ fees, amounts
paid in settlement or expenses, joint or several, (collectively, “Claims”) incurred in investigating, preparing or defending any action, claim, suit, inquiry, proceeding, investigation or appeal taken from the foregoing by or before
any court or governmental, administrative or other regulatory agency, body or the SEC, whether pending or threatened, whether or not an indemnified party is or may be a party thereto (“Indemnified Damages”), to which any of them may
become subject insofar as such Claims (or actions or proceedings, whether commenced or threatened, in respect thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement of a material fact in a Registration
Statement or any post-effective amendment thereto or in any filing made in connection with the qualification of the offering under the securities or other “blue sky” laws of any jurisdiction in which Registrable Securities are offered
(“Blue Sky Filing”), or the omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein not misleading, (ii) any untrue statement or alleged untrue statement
of a material fact contained in any preliminary, final, summary or free writing prospectus (as amended or supplemented, if the Company files any amendment thereof or supplement thereto with the SEC) 

  

 14 

 
or the omission or alleged omission to state therein any material fact necessary to make the statements made therein, in light of the circumstances under
which the statements therein were made, not misleading, (iii) any violation or alleged violation by the Company of the 1933 Act, the 1934 Act, any other law, including any state securities law, or any rule or regulation thereunder relating to
the offer or sale of the Registrable Securities pursuant to a Registration Statement or (iv) any material violation of this Agreement by the Company (the matters in the foregoing clauses (i) through (iv) being, collectively,
“Violations”). Subject to Section 6(c), the Company shall reimburse the Indemnified Persons, promptly as such expenses are incurred and are due and payable, for any legal fees or other reasonable expenses incurred by them in
connection with investigating or defending any such Claim. Notwithstanding anything to the contrary contained herein, the indemnification agreement contained in this Section 6(a): (i) shall not apply to a Claim by an Indemnified Person
arising out of or based upon a Violation which occurs in reliance upon and in conformity with information furnished in writing to the Company by such Indemnified Person for such Indemnified Person expressly for use in connection with the preparation
of the Registration Statement or any such amendment thereof or supplement thereto if such prospectus was timely made available by the Company pursuant to Section 3(d) and (ii) shall not apply to amounts paid in settlement of any Claim if
such settlement is effected without the prior written consent of the Company, which consent shall not be unreasonably withheld. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of the
Indemnified Person and shall survive the transfer of the Registrable Securities by the Investors pursuant to Section 9. 
 b. In connection with any Registration Statement in which an Investor is participating, each such Investor agrees to severally and not jointly indemnify, hold harmless and defend, to the same extent and in the same manner as is set forth in
Section 6(a), the Company, each of its directors, each of its officers who signs the Registration Statement, and each Person, if any, who controls the Company within the meaning of the 1933 Act or the 1934 Act (each an “Indemnified
Party”), against any Claim or Indemnified Damages to which any of them may become subject, under the 1933 Act, the 1934 Act or otherwise, insofar as such Claim or Indemnified Damages arise out of or are based upon any Violation, in each
case to the extent, and only to the extent, that such Violation occurs in reliance upon and in conformity with written information furnished to the Company by such Investor expressly for use in connection with such Registration Statement; and,
subject to Section 6(c), such Investor will reimburse any legal or other expenses reasonably incurred by an Indemnified Party in connection with investigating or defending any such Claim; provided, however, that the indemnity agreement
contained in this Section 6(b) and the agreement with respect to contribution contained in Section 7 shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written consent of such
Investor, which consent shall not be unreasonably withheld; provided, further, however, that the aggregate liability of the Investor in connection with any Violation shall not exceed the net proceeds to such Investor as a result of the sale of
Registrable Securities pursuant to the Registration Statement giving rise to such Claim. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of such Indemnified Party and shall survive the
transfer of the Registrable Securities by the Investors pursuant to Section 9. 
 c. Promptly after receipt by an
Indemnified Person or Indemnified Party under this Section 6 of notice of the commencement of any action or proceeding (including any 

  

 15 

 
governmental action or proceeding) involving a Claim, such Indemnified Person or Indemnified Party shall, if a Claim in respect thereof is to be made against
any indemnifying party under this Section 6, deliver to the indemnifying party a written notice of the commencement thereof, and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so
desires, jointly with any other indemnifying party similarly noticed, to assume control of the defense thereof with counsel mutually satisfactory to the indemnifying party and the Indemnified Person or the Indemnified Party, as the case may be. In
any such proceeding, any Indemnified Person or Indemnified Party may retain its own counsel, but, except as provided in the following sentence, the fees and expenses of that counsel will be at the expense of that Indemnified Person or Indemnified
Party, as the case may be, unless (i) the indemnifying party and the Indemnified Person or Indemnified Party, as applicable, shall have mutually agreed to the retention of that counsel, (ii) the indemnifying party does not assume the
defense of such proceeding in a timely manner or (iii) in the reasonable opinion of counsel retained by the indemnifying party, the representation by such counsel for the Indemnified Person or Indemnified Party and the indemnifying party would
be inappropriate due to actual or potential differing interests between such Indemnified Person or Indemnified Party and any other party represented by such counsel in such proceeding. The Company shall pay reasonable fees for up to one separate
legal counsel for the Investors, and such legal counsel shall be selected by the Investors holding at least two-thirds (2/3) in interest of the Registrable Securities included in the Registration Statement to which the Claim relates. The
Indemnified Party or Indemnified Person shall cooperate fully with the indemnifying party in connection with any negotiation or defense of any such action or Claim by the indemnifying party and shall furnish to the indemnifying party all information
reasonably available to the Indemnified Party or Indemnified Person which relates to such action or Claim. The indemnifying party shall keep the Indemnified Party or Indemnified Person fully apprised at all times as to the status of the defense or
any settlement negotiations with respect thereto. No indemnifying party shall be liable for any settlement of any action, claim or proceeding effected without its prior written consent, provided, however, that the indemnifying party shall not
unreasonably withhold, delay or condition its consent. No indemnifying party shall, without the prior written consent of the Indemnified Party or Indemnified Person, consent to entry of any judgment or enter into any settlement or other compromise
with respect to any pending or threatened action or claim in respect of which indemnification or contribution may be or has been sought hereunder (whether or not the Indemnified Party or Indemnified Person is an actual or potential party to such
action or claim) which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party or Indemnified Person of a release from all liability in respect to such Claim or litigation. Following
indemnification as provided for hereunder, the indemnifying party shall be subrogated to all rights of the Indemnified Party or Indemnified Person with respect to all third parties, firms or corporations relating to the matter for which
indemnification has been made. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action shall not relieve such indemnifying party of any liability to the Indemnified Person or
Indemnified Party under this Section 6, except to the extent that the indemnifying party is prejudiced in its ability to defend such action. 
 d. The indemnification required by this Section 6 shall be made by periodic payments of the amount thereof during the course of the investigation or defense, as and when bills are received or Indemnified Damages
are incurred. 
  

 16 

 e. The indemnity agreements contained herein shall be in addition to (i) any cause
of action or similar right of the Indemnified Party or Indemnified Person against the indemnifying party or others, and (ii) any liabilities the indemnifying party may be subject to pursuant to the law. 
 7. CONTRIBUTION. 
 To
the extent any indemnification by an indemnifying party is prohibited or limited by law, the indemnifying party agrees to make the maximum contribution with respect to any amounts for which it would otherwise be liable under Section 6 to the
fullest extent permitted by law; provided, however, that: (i) no Person involved in the sale of Registrable Securities which Person is guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the 1933 Act) in
connection with such sale, shall be entitled to contribution from any Person involved in such sale of Registrable Securities who was not guilty of fraudulent misrepresentation; and (ii) contribution by any seller of Registrable Securities shall
be limited to an amount equal to the net amount of proceeds received by such seller from the sale of such Registrable Securities pursuant to the Registration Statement giving rise to such action or claim for indemnification less the amount of any
damages that such seller has otherwise been required to pay in connection with such sale. 
 8. REPORTS UNDER THE 1934 ACT.

 With a view to making available to the Investors the benefits of Rule 144 promulgated under the 1933 Act or any other
similar rule or regulation of the SEC that may at any time permit the Investors to sell securities of the Company to the public without registration (“Rule 144”), the Company agrees to: 
 a. make and keep public information available, as those terms are understood and defined in Rule 144; 
 b. file with the SEC in a timely manner all reports and other documents required of the Company under the 1934 Act so long as the Company
remains subject to such requirements (it being understood that nothing herein shall limit the Company’s obligations under Section 4(c) of the Securities Purchase Agreement) and the filing of such reports and other documents is required for
the applicable provisions of Rule 144; and 
 c. furnish to each Investor so long as such Investor owns Registrable
Securities, promptly upon request, (i) a written statement by the Company that it has complied with the reporting requirements of Rule 144 and the 1934 Act, (ii) a copy of the most recent annual or quarterly report of the Company and such
other reports and documents so filed by the Company, and (iii) such other information as may be reasonably requested to permit the investors to sell such securities pursuant to Rule 144 without registration. 
 9. ASSIGNMENT OF REGISTRATION RIGHTS. 
 The rights under this Agreement shall be automatically assignable by the Investors to any transferee of all or any portion of Registrable Securities if: (i) the Investor agrees in writing with the transferee or
assignee to assign such rights, and a copy of such 

  

 17 

 
agreement is furnished to the Company within a reasonable time after such transfer or assignment; (ii) the Company is, within a reasonable time after
such transfer or assignment, furnished with written notice of (a) the name and address of such transferee or assignee, and (b) the securities with respect to which such registration rights are being transferred or assigned;
(iii) immediately following such transfer or assignment the further disposition of such securities by the transferee or assignee is restricted under the 1933 Act and applicable state securities laws; (iv) at or before the time the Company
receives the written notice contemplated by clause (ii) of this sentence, the transferee or assignee agrees in writing with the Company to be bound by all of the provisions contained herein, and the provisions of Section 4(r) of the
Securities Purchase Agreement; and (v) such transfer shall have been made in accordance with the applicable requirements of the Securities Purchase Agreement. 
 10. AMENDMENT OF REGISTRATION RIGHTS. 
 Provisions of this Agreement may be amended
and the observance thereof may be waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and Investors who then hold at least two-thirds (2/3) of the
Registrable Securities. Any amendment or waiver effected in accordance with this Section 10 shall be binding upon each Investor and the Company. No such amendment shall be effective to the extent that it applies to less than all of the holders
of the Registrable Securities. No consideration shall be offered or paid to any Person to amend or consent to a waiver or modification of any provision of any of this Agreement unless the same consideration also is offered to all of the parties to
this Agreement. 
 11. MISCELLANEOUS. 
 a. A Person is deemed to be a holder of Registrable Securities whenever such Person owns or is deemed to own of record such Registrable Securities. If the Company receives conflicting instructions, notices or
elections from two or more Persons with respect to the same Registrable Securities, the Company shall act upon the basis of instructions, notice or election received from the registered owner of such Registrable Securities. 
 b. Any notices, consents, waivers or other communications required or permitted to be given under the terms of this Agreement must be in
writing and will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt, when sent by facsimile (provided confirmation of transmission is mechanically or electronically generated and kept on file
by the sending party); or (iii) one (1) Business Day after deposit with a nationally recognized overnight delivery service, in each case properly addressed to the party to receive the same. The addresses and facsimile numbers for such
communications shall be: 
  

 18 

 If to the Company: 
 On or before March 31, 2006: 
 CardioVascular BioTherapeutics, Inc. 
 7251 W. Lake Mead Blvd., Suite 300 
 Las
Vegas, Nevada 89128 
 Facsimile: (702) 617-5651 
 Attention: Corporate Controller 
 After March 31, 2006: 
 CardioVascular BioTherapeutics, Inc. 
 1635
Village Center Circle, Suite 250 
 Las Vegas, Nevada 89134 
 Facsimile: (702) 617-5651 
 Attention: Corporate Controller 
 With copy to: 
 Lord Bissell &
Brook LLP 
 300 S. Grand Ave. 8th Floor 
 Los Angeles, CA 90071 
 Facsimile: (213) 485-1200 
 Attention: Ronald Warner, Esq. 
 If to Legal Counsel: 
 Katten Muchin
Rosenman LLP 
 525 West Monroe Street 
 Chicago, Illinois 60661-3693 
 Telephone: 312-902-5200 
 Facsimile: 312-902-1061 
 Attention: Mark D. Wood, Esq. 
 If to a Buyer, to its address and facsimile number set forth on the Schedule of Buyers attached hereto, with copies to such Buyer’s representatives as set forth on
the Schedule of Buyers, or, in the case of a Buyer or other party named above, to such other address and/or facsimile number and/or to the attention of such other person as the recipient party has specified by written notice given to each other
party at least five (5) days prior to the effectiveness of such change. Written confirmation of receipt (A) given by the recipient of such notice, consent, waiver or other communication, (B) mechanically or electronically generated by
the sender’s facsimile machine containing the time, date, recipient facsimile number and an image of the first page of such transmission or (C) provided by a courier or overnight courier service shall be rebuttable evidence of personal
service, receipt by facsimile or deposit with a nationally recognized overnight delivery service in accordance with clause (i), (ii) or (iii) above, respectively. Notwithstanding the foregoing, the Company or its counsel may transmit
versions of any Registration Statement (or any amendments or supplements thereto) to Legal Counsel in 

  

 19 

 
satisfaction of its obligations under Section 3(c) to permit Legal Counsel to review such Registration Statement prior to filing (and solely for such
purpose) by email to mark.wood@kattenlaw.com and mark.guidubaldi@kattenlaw.com, provided that delivery and receipt of such transmission shall be confirmed by electronic, telephonic or other means. 
 c. Failure of any party to exercise any right or remedy under this Agreement or otherwise, or delay by a party in exercising such right or
remedy, shall not operate as a waiver thereof. 
 d. All questions concerning the construction, validity, enforcement and
interpretation of this Agreement shall be governed by the internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether of the State of New York or any other jurisdictions) that
would cause the application of the laws of any jurisdictions other than the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting the City of New York, borough of Manhattan,
for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is
not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party hereby irrevocably waives personal
service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service shall constitute good and
sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. If any provision of this Agreement shall be invalid or unenforceable in any
jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this Agreement in that jurisdiction or the validity or enforceability of any provision of this Agreement in any other jurisdiction.
EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY.

 e. This Agreement and the other Transaction Documents constitute the entire agreement among the parties hereto with respect
to the subject matter hereof and thereof. There are no restrictions, promises, warranties or undertakings, other than those set forth or referred to herein and therein. This Agreement and the other Transaction Documents supersede all prior
agreements and understandings among the parties hereto with respect to the subject matter hereof and thereof. 
 f. Subject to
the requirements of Section 9, this Agreement shall inure to the benefit of and be binding upon the permitted successors and assigns of each of the parties hereto. 
 g. The headings in this Agreement are for convenience of reference only and shall not limit or otherwise affect the meaning hereof.

  

 20 

 h. This Agreement may be executed in two or more identical counterparts, all of which
shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to each other party; provided that a facsimile signature shall be considered due execution and shall be binding
upon the signatory thereto with the same force and effect as if the signature were an original, not a facsimile signature. 
 i. Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents, as the other party may reasonably
request in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby. 
 j. All consents and other determinations to be made by the Investors pursuant to this Agreement shall be made, unless otherwise specified in this Agreement, by Investors holding at least two-thirds (2/3) of the
Registrable Securities, determined as if all of the Notes and the Warrants then outstanding have been converted into or exercised for Registrable Securities without regard to any limitations on conversion of the Notes or the exercise of the
Warrants. Any consent or other determination approved by Investors as provided in the immediately preceding sentence shall be binding on all Investors. 
 k. The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent and no rules of strict construction will be applied against any party. 
 l. Each Buyer and each holder of the Securities shall have all rights and remedies set forth in the Transaction Documents and all rights
and remedies that such Buyers and holders have been granted at any time under any other agreement or contract and all of the rights that such Buyers and holders have under any law. Any Person having any rights under any provision of this Agreement
shall be entitled to enforce such rights specifically (without posting a bond or other security or proving actual damages), to recover damages by reason of any breach of any provision of this Agreement and to exercise all other rights granted by
law. 
 m. This Agreement is intended for the benefit of the parties hereto and their respective permitted successors and
assigns and, to the extent provided in Sections 6(a) and 6(b) hereof, each Investor, the directors, officers, partners, members, managers, employees, agents, representatives of, and each Person, if any, who controls any Investor within the meaning
of the 1933 Act and the 1934 Act and each of the Company’s directors, each of the Company’s officers who signs the Registration Statement, and each Person, if any, who controls the Company within the meaning of the 1933 Act and the 1934
Act, and is not for the benefit of, nor may any provision hereof be enforced by, any other Person. 
  

 21 

 n. Unless the context otherwise requires, (a) all references to Sections, Schedules
or Exhibits are to Sections, Schedules or Exhibits contained in or attached to this Agreement, (b) each accounting term not otherwise defined in this Agreement has the meaning assigned to it in accordance with GAAP, (c) words in the
singular or plural include the singular and plural and pronouns stated in either the masculine, the feminine or neuter gender shall include the masculine, feminine and neuter and (d) the use of the word “including” in this Agreement
shall be by way of example rather than limitation. 
 * * * * * * 
  

 22 

 IN WITNESS WHEREOF, the parties have caused this Registration Rights Agreement to be duly executed
as of day and year first above written. 
  

									
	 COMPANY:
	 		 	 BUYERS:

			
	CARDIOVASCULAR BIOTHERAPEUTICS, INC.	 		 	HFTP INVESTMENT L.L.C.
				
		 		 	By:	 	Promethean Asset Management L.L.C.
		 		 	Its:	 	Investment Manager
					
	By:	 	/s/ Mickael A. Flaa	 		 	By:	 	/s/ Robert J. Brantman
	Name:	 	Mickael A. Flaa	 		 	Name:	 	Robert J. Brantman
	Title:	 	Chief Financial Officer	 		 	Title:	 	Partner and Authorized Signatory
			
		 		 	GAIA OFFSHORE MASTER FUND, LTD.
				
		 		 	By:	 	Promethean Asset Management L.L.C.
		 		 	Its:	 	Investment Manager
					
		 		 		 	By:	 	/s/ Robert J. Brantman
		 		 		 	Name:	 	Robert J. Brantman
		 		 		 	Title:	 	Partner and Authorized Signatory
			
		 		 	CAERUS FUND LTD.
				
		 		 	By:	 	Promethean Asset Management L.L.C.
		 		 	Its:	 	Investment Manager
					
		 		 		 	By:	 	/s/ Robert J. Brantman
		 		 		 	Name:	 	Robert J. Brantman
		 		 		 	Title:	 	Partner and Authorized Signatory

			
	LEONARDO, L.P.
		
	By:	 	Leonardo Capital Management, Inc.
	Its:	 	General Partner

					
			
		 	By:	 	Angelo, Gordon & Co., L.P.
		 	Its:	 	Director

			
		
	By:	 	/s/ Michael L. Gordon
	Name:	 	Michael L. Gordon
	Title:	 	Authorized Signatory

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