Document:

Exhibit

	
			
	 
	 
	Exhibit 10.9.2

	CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [**], HAS BEEN OMITTED BECAUSE ARCHERDX, INC. HAS DETERMINED THE INFORMATION (I) IS NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO ARCHERDX, INC. IF PUBLICLY DISCLOSED.

Second Amendment
to Exclusive Patent License Agreement
A217008.05
This Second Amendment (“Second Amendment”) to the Exclusive Patent License Agreement MGH # A217008, (the “Agreement”), dated July 23, 2013 is made as of June 23, 2017 (“Second Amendment Effective Date) by and between The General Hospital Corporation, d/b/a Massachusetts General Hospital, a not-for-profit Massachusetts corporation, with a principal place of business at 55 Fruit Street, Boston, Massachusetts 02114 (“Hospital”) and ArcherDx, Inc., a Delaware Corporation, having a principal place of business at 2477 55th St. # 202 Boulder, Colorado 80301 (“Company”).
RECITALS
		
	A.
	Hospital originally entered into the Agreement with ArcherDx, Inc., a Delaware corporation, having a principal place of business at 16042 W. 59th Ave., Golden, CO80403.

		
	B.
	Company subsequently entered into a merger agreement (the “Merger Agreement”), dated as of July 11, 2013, with Enzymatics, Inc., a Massachusetts corporation (“Enzymatics”).  Pursuant to Section 12.5 of the Agreement, the Agreement was assigned to Enzymatics by merger notified and consented to by Hospital vide letter dated August 27, 2013.

		
	C.
	Enzymatics was acquired by Qiagen North American Holdings, Inc. (“Qiagen”) on December 16, 2015, pursuant to which Qiagen acquired all of the businesses of Enzymatics other than its supply chain and archer business units.  In connection with and prior to the closing of the acquisition of Enzymatics by Qiagen, Qiagen combined its supply chain and archer business units into a new business entity ArcherDx, Inc. (identified in the first paragraph of this First Amendment; “Company”), Qiagen assigned the Agreement to Company, and Hospital previously consented to said assignment on December 3, 2014.

		
	D.
	Hospital and Company subsequently entered into a First Amendment (MGH A217008.04) effective August 15, 2016 (“First Amendment”, and together with the Agreement, the “Amended Agreement”), and now wish to further amend the Amended Agreement as set forth below.

		
	E.
	Company and Hospital, each referred to herein individually as “Party” and collectively as “Parties,” now desire to amend the Amended Agreement as set forth herein.

NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth herein and for good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Parties hereby agree as follows:
1.    Construction.  Capitalized terms used and not defined herein shall have the meanings assigned to such terms in the Amended Agreement.
2.    Amendments to Agreement.
(a) Section 3.1 of the Amended Agreement shall be amended and restated to read in its entirety as follows:
“Diligence Requirements.  Company shall use, and shall cause its Affiliates and Sublicensees, as applicable, to use, commercially reasonable efforts to develop and make available to the public Products and Processes throughout the License Territory in the License Field.  Such efforts shall include achieving the following objectives within the time periods designated below following the Effective Date:
		
	(a)
	Company shall make a First Commercial Sale of a first Product by December 31, 2013, and shall make continuing Sales of such Product without any elapsed time period of one (1) year or more in which such Sales do not occur.

		
	(b)
	Company shall make a First Commercial Sale of a second Product by December 31, 2014, and shall make continuing Sales of such Product without any elapsed time period of one (1) year or more in which such Sales do not occur.

		
	(c)
	Company shall make a First Commercial Sale of a Product in the IVD Field by December 31, 2020, and shall make continuing Sales of such Product without any elapsed time period of one (1) year or more in which such Sales do not occur.

		
	(d)
	Company shall achieve the following levels of Net Sales for the 12 months immediately preceding each of the following dates:

	
				
	Date
	Net Sales

	December 31st, 2014
	

	$2,000,000
	

	December 31st, 2015
	

	$8,000,000
	

	December 31st, 2016
	

	$10,000,000
	

	December 31st, 2017
	

	$12,000,000
	

	December 31st, 2018
	

	$14,000,000
	

	December 31st, 2019
	

	$20,570,000
	

For each subsequent calendar year after the calendar year ending December 31, 2019, the level of Net Sales shall increase by ten percent (10%) over the Net Sales in the immediately preceding 

calendar year. For clarity and by way of example, the Net Sales in the calendar year ending December 31, 2020 shall be $22,627,000.
Achievement of the foregoing objectives shall be deemed to satisfy Company’s obligations to use commercially reasonable efforts under this Section 3.1.”
(b) Section 4.5 (a) of the Agreement shall be amended and restated to read in its entirety as follows:
“Beginning with the First Commercial Sale in any country in the License Territory, Company shall pay Hospital during the term of any license granted under Section 2.1(a)(i), a royalty of [**] of the Net Sales of all Products and Processes.  Notwithstanding the foregoing, for the period of twelve (12) months immediately preceding December 31st 2016, Company shall pay Hospital the greater of (a) [**], and (b) a royalty of [**] of the Net Sales for the twelve (12) months immediately preceding December 31st 2016.  Notwithstanding the foregoing, for the period of twelve (12) months immediately preceding December 31st 2017, Company shall pay Hospital the greater of (a) [**], and (b) a royalty of [**] the Net Sales for the twelve (12) months immediately preceding December 31st 2017.  Notwithstanding the foregoing, for the period of twelve (12) months immediately preceding December 31st 2018, Company shall pay Hospital the greater of (a) [**], and (b) a royalty of [**] of the Net Sales for the twelve (12) months immediately preceding December 31st 2018. The royalty rates contained in this Section 4.5(a) shall be reduced by fifty percent (50%) on a country-by-country basis for any Product or Process, the manufacture, use, sale, importation or performance of which in or into a specific country is not covered by Patent Rights in such country.”

(c) Appendix A of the Amended Agreement shall be amended and restated to read in its entirety as follows:
Appendix A
DESCRIPTION OF PATENT RIGHTS
	
						
	Country
	Status
	Filing Date
	Serial Number
	MGH ID
	Patent Number

	[**]
	[**]
	[**]
	[**]
	21678.03
	 

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	21678.04
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	22318.02
	 

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	21678.07
	 

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	21678.06
	 

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	21678.10
	 

	[**]
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	21678.09
	 

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	21678.08
	 

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	22318.05
	 

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	22318.06
	 

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	22318.03
	 

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	21678.01
	 

	[**]
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	22318.01
	 

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	22318.04
	 

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	22318.07
	 

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	22318.09
	 

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	22318.10
	 

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	22318.11
	 

	[**]
	[**]
	[**]
	[**]
	21678.02
	 

	[**]
	[**]
	[**]
	[**]
	22318.08
	 

3.    Effect of Amendment; Conflicts.  Except as expressly amended by this Second Amendment, the Amended Agreement shall continue in full force and effect.  If there is any conflict between the terms of the Amended Agreement and the terms of this Second Amendment, the terms of this Second Amendment shall govern and control.
4.    Further Assurances.  The Parties agree to execute such further instruments, agreements and documents and to take such further actions as may reasonably be necessary to carry out the intent of this Second Amendment.
5.    Counterparts.  This Second Amendment may be executed in any number of counterparts, each which shall be deemed an original, and all of which together shall constitute one instrument.

6.    Entire Agreement.  This Second Amendment, together with the Amended Agreement and the documents referenced herein and therein, constitute the full and entire understanding and agreement among the parties with regard to the subjects hereof and thereof.
[Signature page follows]

IN WITNESS WHEREOF, the parties have executed this Second Amendment as of the Second Amendment Effective Date.
	
			
	THE GENERAL HOSPITAL CORPORATION

	 
	 
	 

	By:
	/s/ Rebecca Listfield

	 
	 
	 

	Name:
	Rebecca Listfield, Ph.D.

	 
	 
	Associate Director, Licensing

	 
	 
	 

	Title
	Partners HealthCare Innovation

	June 30, 2017

	 
	 
	 

	ARCHERDX, INC.

	 
	 
	 

	By:
	/s/ Christian LaPointe

	 
	 
	 

	Name:
	Christian LaPointe

	 
	 
	 

	Title
	General CounselExhibit

Exhibit 10.10.1

AMENDMENT NO. 1 TO SUPPLY AGREEMENT
This Amendment No. 1 to Supply and Manufacturing Agreement (“Amendment”) is made as of December 20, 2016 and amends certain portions of the Supply and Manufacturing Agreement (the “Agreement”), dated as of December 16, 2014, by and between Qiagen, Inc. (“Qiagen”) and ArcherDx, Inc., (“ArcherDx”).
RECITALS
A.    The Agreement sets forth certain rights and obligations of each of the Parties relating to the supply of certain Products by Qiagen for ArcherDX; and 
B.    The Parties now desire to amend the Agreement as set forth herein.
NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth herein and for good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Parties hereby agree as follows: 
1.    Construction.  Capitalized terms used and not defined herein shall have the meanings assigned to such terms in the Agreement.
2.    Amendments to Agreement.
Annex 1.6 of the Agreement shall be amended and restated to read in its entirety as set forth on Annex 1.6 hereto.
3.    Effect of Amendment; Conflicts.  Except as expressly amended by this Amendment, the Agreement shall continue in full force and effect. If there is any conflict between the terms of the Agreement and the terms of this Amendment, the terms of this Amendment shall govern and control.
4.    Further Assurances.  The parties agree to execute such further instruments, agreements and documents and to take such further actions as may reasonably be necessary to carry out the intent of this Amendment.
5.    Counterparts.  This Amendment may be executed in any number of counterparts, each which shall be deemed an original, and all of which together shall constitute one instrument.
6.    Entire Agreement.  This Amendment, together with the Agreement and the documents referenced herein and therein, constitute the full and entire understanding and agreement among the parties with regard to the subjects hereof and thereof.
[Signature page follows]

IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.
	
		
	QIAGEN, INC.

	 
	 

	By:
	          /s/ Douglas Liu

	 
	 

	Name:
	          Douglas Liu

	 
	 

	Title:
	          Senior VP Global Operations

	 
	QIAGEN

	 
	 

	 
	 

	ARCHERDX, INC.

	 
	 

	By:
	          /s/ Christian LaPointe

	 
	 

	Name:
	          Christian LaPointe

	 
	 

	Title:
	          General Counsel

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