Document:

Second Amendment, dated as of December 11, 2006

 Exhibit 4.6 
 SECOND AMENDMENT TO RIGHTS AGREEMENT 
 BETWEEN TELIK, INC. AND 
 COMPUTERSHARE SHAREHOLDER SERVICES, INC. AND 
 COMPUTERSHARE TRUST COMPANY, N.A. 
 THIS SECOND AMENDMENT TO
RIGHTS AGREEMENT (the “Amendment”) is made this 11th day of December, 2006, by and between TELIK, INC., a Delaware corporation (the “Company”),
and COMPUTERSHARE SHAREHOLDER SERVICES, INC. AND COMPUTERSHARE TRUST COMPANY, N.A. (the “Rights Agent”) to amend
the Rights Agreement, dated November 2, 2001, by and between the Company and Wells Fargo Bank Minnesota, N.A., replaced by Computershare Shareholder Services, Inc. and Computershare Trust Company, N.A., as Rights Agent (the “Rights
Agreement”). 
 WHEREAS, pursuant to the Rights Agreement, certain rights to purchase shares of the Company’s
Series A Junior Participating Preferred Stock, par value $0.01 per share, become exercisable, subject to the terms and conditions set forth in the Rights Agreement, if there is a public announcement that a person, entity or group of affiliated or
associated persons have acquired beneficial ownership of 20% or more of the outstanding Common Shares of the Company (an “Acquiring Person”) or 10 business days following the commencement of, or announcement of an intention to commence, a
tender offer or exchange offer, the consummation of which would result in any person or entity becoming an Acquiring Person; 
 WHEREAS, on May 18, 2006, pursuant to Section 27 of the Rights Agreement, the Rights Agreement was amended to exclude Eastbourne Capital Management, L.L.C. (“ECM”), Black Bear Offshore Master Fund,
L.P., a Cayman Islands limited partnership (“BBOM”), and Richard J. Barry (“Barry,” and together with ECM, BBOM, Black Bear Fund I, L.P., a California limited partnership, and Black Bear Fund II, L.L.C., a California limited
liability company, the “Eastbourne Entities”) from the definition of an “Acquiring Person”, but only so long as none of the Eastbourne Entities, together with any of their respective affiliates or associates, either individually
or collectively, is the beneficial owner of 25% or more of the Common Shares then outstanding; 
 WHEREAS, the
Eastbourne Entities have reported that they beneficially owned in the aggregate 23.6% of the Common Shares of the Company; 
 WHEREAS, pursuant to Section 27 of the Rights Agreement, the Board of Directors of the Company has determined that it is in the best interest of the Company and its stockholders to amend the Rights Agreement to
exclude the Eastbourne Entities from the definition of an “Acquiring Person”, but only so long as none of the Eastbourne Entities, together with any of their respective affiliates or associates, either individually or collectively, is the
beneficial owner of 30% or more of the Common Shares then outstanding (the “Eastbourne Percentage”); provided, however, that effective at 11:59 pm Eastern Time on the date (the “Measurement Date”) on which the Company publicly
announces that it has received approval from the U.S. Food and Drug Administration to market the Company’s product candidate that is known as Telcyta as of the date of this Agreement, the Eastbourne Percentage would be automatically, and
without further action or approval of the Company or any of the Eastbourne Entities or their respective Affiliates or Associates, amended to be the greater of (a) 25% or (b) the percentage (not to exceed 30%) of the Beneficial Ownership of
the Common Shares outstanding collectively held by the Eastbourne Entities together with any of their respective Affiliates or Associates, either individually or collectively, as of the Measurement Date; and 
 WHEREAS, the Board of Directors of the Company has approved this Second Amendment and authorized its appropriate officers to
execute and deliver the same to the Rights Agent. 

 NOW, THEREFORE, in accordance with the procedures for amendment of
the Rights Agreement set forth in Section 27 thereof, and in consideration of the foregoing and the mutual agreements herein set forth, the parties hereby agree as follows: 
 1.  Capitalized terms that are not otherwise defined herein shall have the meanings ascribed to them in the Rights Agreement. 

2.  The definition of “Acquiring Person” set forth in Section 1(a) of the Rights Agreement is amended in its entirety
to read as follows: 
 “Acquiring Person” shall mean any Person (as such term is hereinafter defined) who or which, together with
all Affiliates and Associates (as such terms are hereinafter defined) of such Person, shall be the Beneficial Owner (as such term is hereinafter defined) of 20% or more of the Common Shares then outstanding. Notwithstanding the foregoing,
(A) the term Acquiring Person shall not include (i) the Company, (ii) any Subsidiary (as such term is hereinafter defined) of the Company, (iii) any employee benefit or compensation plan of the Company or any Subsidiary of the
Company, (iv) any entity holding Common Shares for or pursuant to the terms of any such employee benefit or compensation plan, or (v) any of Eastbourne Capital Management, L.L.C. (solely in connection with investment power exercisable by
Eastbourne Capital Management, L.L.C. with respect to Common Shares managed for Black Bear Offshore Master Fund, L.P., a Cayman Islands limited partnership, Black Bear Fund I, L.P., a California limited partnership, and Black Bear Fund II, L.L.C., a
California limited liability company), Black Bear Offshore Master Fund, L.P., a Cayman Islands limited partnership, Black Bear Fund I, L.P., a California limited partnership, Black Bear Fund II, L.L.C., a California limited liability company, and
Richard J. Barry (collectively the “Eastbourne Entities”), but only so long as none of the Persons described in this clause (v), together with any of their respective Affiliates or Associates, either individually or collectively, is the
Beneficial Owner of 30% or more of the Common Shares then outstanding (the “Eastbourne Percentage”); provided, however, that effective at 11:59 pm Eastern Time on the date (the “Measurement Date”) on which the Company publicly
announces that it has received approval from the U.S. Food and Drug Administration to market the Company’s product candidate that is known as Telcyta as of the date of this Agreement, the Eastbourne Percentage would be automatically, and
without further action or approval of the Company or any of the Eastbourne Entities or their respective Affiliates or Associates, amended to be the greater of (a) 25% or (b) the percentage (not to exceed 30%) of the Beneficial Ownership of
the Common Shares outstanding collectively held by the Eastbourne Entities, together with any of their respective Affiliates or Associates, either individually or collectively, as of the Measurement Date, and (B) no Person shall become an
“Acquiring Person” either (x) as the result of an acquisition of Common Shares by the Company which, by reducing the number of shares outstanding, increases the proportionate number of shares beneficially owned by such Person to 20%
(or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities) or more of the Common Shares then outstanding by reason of share purchases by the Company and shall, following written notice from, or public disclosure by the
Company of such share purchases by the Company, become the Beneficial Owner of any additional Common Shares without the prior consent of the Company and shall then Beneficially Own more than 20% (or the Eastbourne Percentage then in effect with
respect to the Eastbourne Entities) of the Common Shares then outstanding, then such Person shall be deemed to be an “Acquiring Person,” (y) as the result of the acquisition of Common Shares directly from the Company, provided,
however that if a Person shall become the Beneficial 

 Owner of 20% (or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities) or
more of the Common Shares then outstanding by reason of share purchases directly from the Company and shall, after that date, become Beneficial Owner of any additional Common Shares without the prior written consent of the Company and shall then
Beneficially Own more than 20% (or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities) of the Common Shares then outstanding, then such Person shall be deemed to be an “Acquiring Person” or (z) if the
Board of Directors determines in good faith that a Person who would otherwise be an “Acquiring Person,” as defined pursuant to the foregoing provisions of this paragraph (a), has become such inadvertently, and such Person divests, as
promptly as practicable (as determined in good faith by the Board of Directors), but in any event within five Business Days, following receipt of written notice from the Company of such event, of Beneficial Ownership of a sufficient number of Common
Shares so that such Person would no longer be an Acquiring Person, as defined pursuant to the foregoing provisions of this paragraph (a), then such Person shall not be deemed to be an “Acquiring Person” for any purposes of this Agreement;
provided, however, that if such Person shall again become the Beneficial Owner of 20% (or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities) or more of the Common Shares then outstanding, such Person shall be deemed an
“Acquiring Person,” subject to the exceptions set forth in this Section 1(a).” 
 3.  All references in
the Rights Agreement to “20%” shall be followed by “(or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities)”, other than in the definition of “Acquiring Person” set forth in
Section 1(a), which is amended as provided above. 
 4.  Except as expressly set forth herein, this Second Amendment
shall not alter, modify, amend or in any affect any of the terms, conditions, covenants, obligations or agreements contained in the Rights Agreement, all of which are ratified and affirmed in all respects and shall continue to be in full force and
effect. 
 5.  If any term, provision, covenant or restriction of this Second Amendment is held by a court of competent
jurisdiction or other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Second Amendment shall remain in full force and effect and shall in no way be affected, impaired or
invalidated. 
 6.  This Second Amendment shall be deemed to be a contract made under the laws of the State of Delaware and
for all purposes shall be governed by and construed in accordance with the laws of such State applicable to contracts to be made and performed entirely within such State. 
 7.  This Second Amendment may be executed in any number of counterparts and each of such counterparts shall for all purposes be deemed to be an original, and all such counterparts shall together
constitute but one and the same instrument. 
 [SIGNATURE PAGE TO FOLLOW] 

 IN WITNESS WHEREOF, the parties herein have caused
this Second Amendment to be duly executed and attested, all as of the date and year first above written. 
  

			
	TELIK, INC.
		
	By:	 	 /s/ Dr. Michael M. Wick

	Name:	 	Dr. Michael M. Wick
	Title:	 	Chairman, President and Chief Executive Officer
	
	COMPUTERSHARE SHAREHOLDER SERVICES, INC.
		
	By:	 	 /s/ Dennis Moccia

	Name:	 	Dennis Moccia
	Title:	 	Managing Director
	
	COMPUTERSHARE TRUST COMPANY, N.A.
		
	By:	 	 /s/ Dennis Moccia

	Name:	 	Dennis Moccia
	Title:	 	Managing DirectorAmended and Restated Agreement, dated December 11, 2006

 Exhibit 10.2 
 AMENDED AND RESTATED AGREEMENT 
 This Amended and Restated Agreement (this “Agreement”) is
entered into effective as of December 11, 2006, by and among Eastbourne Capital Management, L.L.C. (“ECM”), Black Bear Offshore Master Fund, L.P., a Cayman Islands limited partnership (“BBOM”), Black Bear Fund I, L.P., a
California limited partnership (“BB I”), Black Bear Fund II, L.L.C., a California limited liability company (“BB II”), and Richard J. Barry (“Barry,” and together with ECM, BBOM, BB I and BB II, “Eastbourne”)
and Telik, Inc., a Delaware corporation (the “Company”). Capitalized terms not defined herein will have the meaning given in the Rights Agreement, dated November 2, 2001, by and between the Company and Wells Fargo Bank Minnesota,
N.A., replaced by Computershare Shareholder Services, Inc. and Computershare Trust Company, N.A., as Rights Agent (the “Rights Agreement”). 
 A. The Company and Eastbourne previously entered into that certain “standstill” Agreement dated as of May 18, 2006 (the “Prior Agreement”), and now desire to amend and restate the Prior
Agreement and to accept the rights and obligations created pursuant hereto in lieu of the rights and obligations of the Prior Agreement. 
 B. Pursuant to Section 1 of the Rights Agreement, a Person who or which, together with all Affiliates and Associates (each as defined in the Rights Agreement), becomes the Beneficial Owner of 20% or more of the issued and outstanding
Common Stock of the Company is an “Acquiring Person” for purposes of the Rights Agreement. 
 C. On May 18, 2006, the Board of
Directors of the Company amended the Rights Agreement to exclude Eastbourne from the definition of an “Acquiring Person”, but only so long as Eastbourne, together with their respective Affiliates or Associates, either individually or
collectively, is not the beneficial owner of 25% or more of the Common Stock of the Company then outstanding. 
 D. As of December 11,
2006, Eastbourne had Beneficial Ownership, in the aggregate, of approximately 13,079,474 shares of the Common Stock of the Company, $0.01 par value per share (the “Common Stock”). 
 E. Except as otherwise disclosed in the most recent Schedule 13G filed by Eastbourne, Eastbourne’s Beneficial Ownership of the Common Stock is
primarily attributable to investment power exercisable by ECM with respect to shares of the Common Stock managed for its clients. 
 F.
Eastbourne has indicated to the Company that it desires to purchase additional shares of the Common Stock on behalf of its clients and itself in amounts likely to cause Eastbourne’s Beneficial Ownership to exceed 25% of the issued and
outstanding shares of the Common Stock. 
 G. The Company has determined that purchases of a limited number of additional shares of the
Common Stock by Eastbourne pursuant to the terms of this Agreement would not currently be adverse or hostile to the Company or inconsistent with the purpose and intent of the Board of Directors of the Company in adopting the Rights Agreement.

 Accordingly, in consideration of the foregoing premises and the mutual covenants, representations and
warranties contained in this Agreement, Eastbourne and the Company hereby agree that the Prior Agreement shall be superseded and replaced in its entirety by this Agreement, and the parties hereto further agree as follows: 
 1. Representations and Warranties of Eastbourne. ECM, BBOM, BB I, BB II and Barry jointly and severally represent and warrant to, and agree with,
the Company as follows: 
 (a) Assuming that a report pursuant to Section 13(g) of the Securities Exchange Act of 1934, as amended, and
the rules and regulations thereunder (the “Exchange Act”) were required to have been filed as of December 11, 2006, Eastbourne would have reported Beneficial Ownership of an aggregate of 13,079,474 shares of the Common Stock (the
“Original Shares”) consisting of approximately 24.98% of the issued and outstanding shares of the Common Stock as of such date (assuming that 52,359,329 shares of Common Stock are issued and outstanding), subject to such disclaimers of
Beneficial Ownership by Eastbourne that may have been made pursuant to such Section and the rules and regulations thereunder. 
 (b) As of
the date hereof, Eastbourne’s Beneficial Ownership of the Common Stock does not exceed 25% of the issued and outstanding Common Stock, assuming that 52,359,329 shares of Common Stock are issued and outstanding. 
 (c) Each Eastbourne entity has been provided with access to, or has received, a copy of, and is familiar with the terms of, the Rights Agreement and the
Amendment to the Rights Agreement effective as of May 18, 2006 (the “First Amendment”). 
 (d) The Original Shares were
acquired (i) in the ordinary course of business solely for investment purposes, (ii) not for the purpose of, and do not have the effect of, changing or influencing the control of the Company and (iii) not in connection with or as a
participant in any transaction having such purposes or effect. 
 (e) With the exception of ECM’s other clients, and their fiduciaries,
to the knowledge of ECM, BBOM, BB I, BB II and Barry, no Person other than Eastbourne is a Beneficial Owner of any of the Original Shares. 
 (f) Any additional shares of the Common Stock purchased by ECM, BBOM, BB I, BB II or Barry or their affiliates after the date hereof (the “Additional Shares,” and together with the Original Shares, the “Eastbourne
Shares”) will be acquired (i) in the ordinary course of business solely for investment purposes, (ii) not for the purpose of, or with the effect of, changing or influencing the control of the Company and (iii) not in connection
with or as a participant in any transaction having such purpose or effect. 
 (g) The Company has not induced, and is not inducing,
Eastbourne or their affiliates, or the clients of ECM, to purchase any additional shares of the Common Stock and has not made and is not making any representation to Eastbourne or the clients of ECM as to the value of the Common Stock, the
suitability of the Common Stock for investment by Eastbourne or the clients of ECM, or the past or future results of the Company’s business and operations. 

 (h) ECM has sole voting and investment control over all of the Original Shares and will have sole voting
and investment control over any Additional Shares. 
 2. Voting of Shares. ECM shall vote the Original Shares in the manner in which
the Board of Directors of the Company has recommended generally in any proxy or consent solicitation to the stockholders of the Company, subject to ECM’s fiduciary duty to its clients. ECM shall vote the Additional Shares in the manner in which
the Board of Directors of the Company has recommended generally in any proxy or consent solicitation to the stockholders of the Company. 
 3. Sale of Shares. In the event that, within five (5) years after the date hereof, any of ECM, BBOM, BB I, BB II or Barry proposes to sell in a bona fide transaction any shares of the Common Stock (other than (i) a sale in
a “broker’s transaction” or in a transaction directly with a “market maker,” in either case as defined in and in a manner of sale consistent with paragraphs (f) and (g) of Rule 144 promulgated under the Securities
Act of 1933, as amended (the “1933 Act”), or (ii) in a sale from one ECM client to another ECM client), then Eastbourne shall provide to the Company not less than ten (10) days prior written notice of such proposed transaction,
specifying the number of shares of the Common Stock proposed to be sold, the price at which such shares are to be sold and the proposed purchaser of such shares, and shall only complete such sale with the written consent of the Company (the
“Consent”), such Consent to be provided or withheld at the Company’s sole discretion and without regard to the economic consequences of providing or withholding such Consent. ECM, BBOM, BB I, BB II and Barry shall jointly and
severally indemnify and hold harmless the Company and its representatives and employees from and against any liability, demand, cost of judgment or claim to which the Company may become subject (regardless of whether or not such liability, demand,
cost or claim relates to any third party claim) that arises out of or relates to the providing or withholding of any Consent. The obligations of ECM, BBOM, BB I, BB II and Barry in the preceding sentence shall be in effect regardless of whether this
Section 3 is otherwise in effect and survive the expiration or termination of this Agreement. The parties acknowledge that nothing in this Agreement, including, without limitation, this section 3, implies that Eastbourne is an affiliate of the
Company as that term is defined in Rule 144 under the 1933 Act. 
 4. Standstill. ECM, BBOM, BB I, BB II and Barry jointly and
severally agree with the Company that none of them shall: 
 (a) make, offer or propose (whether publicly or otherwise) to effect, initiate,
cause or participate in (i) any acquisition of Beneficial Ownership of the Common Stock resulting in an increase in its aggregate Beneficial Ownership of the Common Stock to a number of shares representing 30% or more of the outstanding shares
of the Common Stock (the “Eastbourne Percentage”) at any time without the prior written consent of the Company; provided, however, that effective at 11:59 pm Eastern Time on the date (the “Measurement Date”) on which the
Company publicly announces that it has received approval from the U.S. Food and Drug Administration to market the Company’s product candidate that is known as Telcyta as of the date of this Agreement, the Eastbourne Percentage would be
automatically, and without further action or approval of the Company or Eastbourne, or any of their respective Affiliates or Associates, amended to be the greater of (a) 25% or (b) the percentage (not to exceed 30%) of the Beneficial
Ownership of the Common Stock outstanding held by Eastbourne, together with 

 any of their respective Affiliates or Associates, either individually or collectively, as of the Measurement Date,
(ii) any acquisition of any assets, indebtedness or businesses of the Company or any assets, indebtedness or businesses of any subsidiary or other affiliate of the Company, (iii) any tender offer, exchange offer, merger, business
combination, recapitalization, restructuring, liquidation, dissolution or extraordinary transaction involving the Company or any subsidiary or other affiliate of the Company, or involving any securities, assets, indebtedness or businesses of the
Company or any securities, assets, indebtedness or businesses of any subsidiary or other affiliate of the Company (it being understood that “participate” does not preclude Eastbourne and its clients from tendering shares in any transaction
described in this clause (iii) as long as Eastbourne is passive in such transaction and otherwise has complied with this section 4 with respect to such transaction), (iv) any “solicitation” of “proxies” or stockholder
consents (as such terms are defined under Regulation 14A of the Exchange Act) with respect to any securities of the Company or any of its subsidiaries or other affiliates of the Company or (v) any stockholder proposals or recommendations or
nominations for election to the Board of Directors of the Company that would require disclosure in the Company’s proxy statement prepared in connection with its annual meetings of stockholders; 
 (b) form, join or in any way participate in a “group” (within the meaning of Section 13(d)(3) of the Exchange Act) with respect to any
securities of the Company or any of its subsidiaries, or otherwise act in concert with any person in respect to any such securities, except that the ECM clients may be considered to be a “group”; 
 (c) otherwise act, whether alone or in concert with others, to seek to propose to the Company, any subsidiary of the Company or any of their stockholders
any merger, business combination, restructuring, recapitalization or similar transaction to or with the Company or any of its subsidiaries or otherwise seek or propose to influence or control the Company’s management, Board of Directors or
policies or to obtain representation on the Company’s Board of Directors; 
 (d) take any action that might require the Company to make
a public announcement regarding any of the types of matters set forth in clause “(a)” of this sentence; 
 (e) agree or offer to
take, or encourage or propose (publicly or otherwise) the taking of, any action referred to in clause “(a)”, “(b)”, “(c)” or “(d)” of this sentence; 
 (f) assist, induce or encourage any other Person to take any action of the type referred to in clause “(a)”, “(b)”, “(c)”,
“(d)” or “(e)” of this sentence; 
 (g) enter into any discussions, negotiations, arrangement or agreement with any other
Person relating to any of the foregoing; or 
 (h) request or propose that the Company or any of the Company’s representatives amend,
waive or consider the amendment or waiver of any provision set forth in this section 4. 
 ECM, BBOM, BB I, BB II and Barry jointly and
severally agree that, if any of them or its representatives are approached by any third party concerning any of their participation in a transaction involving any assets, indebtedness or business of, or securities issued by, the Company or any of
its subsidiaries or other affiliates, Eastbourne will promptly inform the Company of the nature of such transaction and the parties involved. 

 Notwithstanding anything in this section 4 to the contrary, ECM, BBOM, BB I, BB II or Barry may take any
action or enter into any agreement, if recommended or approved by the Board of Directors of the Company. 
 5. Amendment to Rights
Agreement. Subject to the terms and conditions of this Agreement and in reliance upon the representations and warranties of ECM, BBOM, BB I, BB II and Barry contained in this Agreement, the Company agrees to amend the definition of Acquiring
Person in the Rights Agreement to provide that the percentage Beneficial Ownership of the outstanding Common Stock used to determine whether a Person constitutes an “Acquiring Person” will be 30% or more in the case of Eastbourne;
provided however, that on the Measurement Date the Eastbourne Percentage would be automatically, and without further action or approval of the Company or Eastbourne, or any of their respective Affiliates or Associates, amended to be the
greater of (a) 25% or (b) the percentage (not to exceed 30%) of the Beneficial Ownership of the Common Stock outstanding held by Eastbourne, together with any of their respective Affiliates or Associates, either individually or
collectively, as of the Measurement Date. Promptly following the effective date of this Agreement and approval by the Board of Directors of the Company, appropriate officers of the Company will execute a second amendment to the Rights Agreement in
substantially the form attached hereto as Exhibit A (the “Second Amendment”), instruct the Rights Agent to execute the Second Amendment and notify Eastbourne when the Second Amendment has been fully executed. ECM, BBOM, BB I, BB II
and Barry hereby covenant and agree not to effect any purchases or sales of the Common Stock before the first business day after the date of filing by the Company of a Form 8-K with the Securities and Exchange Commission reporting such Second
Amendment. Notwithstanding any other provision hereof or of such Second Amendment, the Second Amendment will have no effect on the definition of “Acquiring Person” with respect to any client of ECM other than BBOM, BB I and BB II.

 6. Certain Provisions Unaffected. It is expressly understood and agreed that, notwithstanding the terms of this Agreement or the
Amendment, the Company shall not be precluded from a determination that ECM, BBOM, BB I, BB II or Barry or any client of ECM, is a Person causing the occurrence of a Section 11(a)(ii) event under Section 11(a)(ii) of the Rights Agreement.

 7. Certain Statutory Matters. ECM, BBOM, BB I, BB II and Barry understand and agree that the provisions of Section 203 of the
Delaware General Corporation Law, as amended, will continue to apply to Eastbourne entities, as well as the clients of ECM, and that execution and delivery of this Agreement and the Amendment on behalf of the Company do not constitute approval of
any acquisition of shares of the Common Stock by ECM, BBOM, BB I, BB II, Barry or the clients of ECM, or any other transaction, for the purposes of such Section 203 and do not result in Eastbourne entities or the clients of ECM, not being,
collectively or individually, an “interested stockholder” or “associate” as defined therein. ECM, BBOM, BB I, BB II and Barry acknowledge and agree that, except with respect to the matters contemplated by this Agreement, the
Company has not disclosed material nonpublic information to Eastbourne or any of ECM’s clients and that the Company is under no obligation to disclose such information to Eastbourne or any of ECM’s clients. 

 8. Entire Agreement and Amendment. This Agreement contains the entire agreement among the parties
with respect to the subject matter of this Agreement. All prior and contemporaneous agreements, discussions or understandings, whether oral or written, including the Prior Agreement, are expressly superseded by this Agreement and are null and void.
This Agreement may not be modified, waived, discharged or amended, in whole or in part, except in writing signed by the parties. 
 9.
Termination and Effect Thereof. 
 (a) Except to the extent provided by Section 3 of this Agreement, Sections 2, 3 and 4 of this
Agreement will not be in effect at any time that Eastbourne Beneficially Owns less than 25% of the outstanding shares of the Common Stock, and, from and after the second anniversary hereof, the Company shall have the right to terminate this
Agreement and reverse the First Amendment and the Second Amendment, in its sole discretion, from and after the date on which Eastbourne has not Beneficially Owned 25% or more of the outstanding shares of the Common Stock for a period of at least 20
trading days. 
 (b) If any of ECM, BBOM, BB I, BB II or Barry breaches its covenants, representations or agreements in this Agreement, the
Company will have the right to terminate this Agreement and to reverse the First Amendment and the Second Amendment; provided, however, that any such termination will not prejudice any claim that the Company may have with respect to any
breach of any representation, warranty or covenant hereunder occurring prior to such termination. 
 10. No Third Party Beneficiaries.
This Agreement is solely for the benefit of the parties hereto and is not intended to confer upon any other person any rights or remedies hereunder. 
 11. Governing Law and Venue. This Agreement and the legal relations among the parties hereto will be governed by, construed and enforced according to the internal laws of the State of Delaware (without regard
to the laws of conflict of any jurisdiction) as to all matters, including, without limitation, matters of validity, interpretation, construction, effect, performance and remedies. The parties to this Agreement hereby consent to the personal
jurisdiction of the state and federal courts located in the State of Delaware in connection with any controversy related to this Agreement. 
 12. Counterparts; Facsimile. This Agreement may be executed in one or more counterparts, and each such counterpart will be deemed an original, but all such counterparts together will constitute one and the same instrument. Facsimile
signatures shall be treated the same as originals. 

 The parties have caused this Agreement to be duly executed as of the date and year first above written.

  

							
	EASTBOURNE CAPITAL MANAGEMENT, L.L.C.	  	TELIK, INC.
				
	By:	 	 /s/ Eric M. Sippel
	  	By:	 	 /s/ Dr. Michael M. Wick

		 	Eric M. Sippel	  		 	Dr. Michael M. Wick
				
	Its:	 	Chief Operating Officer	  	Its:	 	Chairman, President and Chief Executive Officer
			
		 	 /s/ Richard J. Barry
	  	BLACK BEAR OFFSHORE MASTER FUND, L.P.
		 	Richard J. Barry	  		 	
			
		 		  	By Eastbourne Capital Management, L.L.C.,
its general partner
				
		 		  	By:	 	 /s/ Eric M. Sippel

		 		  		 	Eric M. Sippel
				
		 		  	Its:	 	Chief Operating Officer

			
	BLACK BEAR FUND I, L.P.
	
	By Eastbourne Capital Management, L.L.C.,
its general partner
		
	By:	 	 /s/ Eric M. Sippel

		 	Eric M. Sippel
		
	Its:	 	Chief Operating Officer
	
	BLACK BEAR FUND II, L.L.C.
	
	By Eastbourne Capital Management, L.L.C.,
its managing member
		
	By:	 	 /s/ Eric M. Sippel

		 	Eric M. Sippel
		
	Its:	 	Chief Operating Officer

 Exhibit A 
 SECOND AMENDMENT TO RIGHTS AGREEMENT 
 BETWEEN TELIK, INC. AND 
 COMPUTERSHARE SHAREHOLDER SERVICES, INC. AND 
 COMPUTERSHARE TRUST COMPANY, N.A. 
 THIS SECOND AMENDMENT TO
RIGHTS AGREEMENT (the “Amendment”) is made this 11th day of December, 2006, by and between TELIK, INC., a Delaware corporation (the “Company”),
and COMPUTERSHARE SHAREHOLDER SERVICES, INC. AND COMPUTERSHARE TRUST COMPANY, N.A. (the “Rights Agent”) to amend
the Rights Agreement, dated November 2, 2001, by and between the Company and Wells Fargo Bank Minnesota, N.A., replaced by Computershare Shareholder Services, Inc. and Computershare Trust Company, N.A., as Rights Agent (the “Rights
Agreement”). 
 WHEREAS, pursuant to the Rights Agreement, certain rights to purchase shares of the Company’s
Series A Junior Participating Preferred Stock, par value $0.01 per share, become exercisable, subject to the terms and conditions set forth in the Rights Agreement, if there is a public announcement that a person, entity or group of affiliated or
associated persons have acquired beneficial ownership of 20% or more of the outstanding Common Shares of the Company (an “Acquiring Person”) or 10 business days following the commencement of, or announcement of an intention to commence, a
tender offer or exchange offer, the consummation of which would result in any person or entity becoming an Acquiring Person; 
 WHEREAS, on May 18, 2006, pursuant to Section 27 of the Rights Agreement, the Rights Agreement was amended to exclude Eastbourne Capital Management, L.L.C. (“ECM”), Black Bear Offshore Master Fund,
L.P., a Cayman Islands limited partnership (“BBOM”), and Richard J. Barry (“Barry,” and together with ECM, BBOM, Black Bear Fund I, L.P., a California limited partnership, and Black Bear Fund II, L.L.C., a California limited
liability company, the “Eastbourne Entities”) from the definition of an “Acquiring Person”, but only so long as none of the Eastbourne Entities, together with any of their respective affiliates or associates, either individually
or collectively, is the beneficial owner of 25% or more of the Common Shares then outstanding; 
 WHEREAS, the
Eastbourne Entities have reported that they beneficially owned in the aggregate 23.6% of the Common Shares of the Company; 
 WHEREAS, pursuant to Section 27 of the Rights Agreement, the Board of Directors of the Company has determined that it is in the best interest of the Company and its stockholders to amend the Rights Agreement to
exclude the Eastbourne Entities from the definition of an “Acquiring Person”, but only so long as none of the Eastbourne Entities, together with any of their respective affiliates or associates, either individually or collectively, is the
beneficial owner of 30% or more of the Common Shares then outstanding (the “Eastbourne Percentage”); provided, however, that effective at 11:59 pm Eastern Time on the date (the “Measurement Date”) on which the Company publicly
announces that it has received approval from the U.S. Food and Drug Administration to market the Company’s product candidate that is known as Telcyta as of the date of this Agreement, the Eastbourne Percentage would be automatically, and
without further action or approval of the Company or any of the Eastbourne Entities or their respective Affiliates or Associates, amended to be the greater of (a) 25% or (b) the percentage (not to exceed 30%) of the Beneficial Ownership of
the Common Shares outstanding collectively held by the Eastbourne Entities together with any of their respective Affiliates or Associates, either individually or collectively, as of the Measurement Date; and 

 WHEREAS, the Board of Directors of the Company has approved this Second Amendment
and authorized its appropriate officers to execute and deliver the same to the Rights Agent. 
 NOW,
THEREFORE, in accordance with the procedures for amendment of the Rights Agreement set forth in Section 27 thereof, and in consideration of the foregoing and the mutual agreements herein set forth, the parties hereby agree as
follows: 
 1.  Capitalized terms that are not otherwise defined herein shall have the meanings ascribed to them in the
Rights Agreement. 
 2.  The definition of “Acquiring Person” set forth in Section 1(a) of the Rights
Agreement is amended in its entirety to read as follows: 
 “Acquiring Person” shall mean any Person (as such term is hereinafter
defined) who or which, together with all Affiliates and Associates (as such terms are hereinafter defined) of such Person, shall be the Beneficial Owner (as such term is hereinafter defined) of 20% or more of the Common Shares then outstanding.
Notwithstanding the foregoing, (A) the term Acquiring Person shall not include (i) the Company, (ii) any Subsidiary (as such term is hereinafter defined) of the Company, (iii) any employee benefit or compensation plan of the
Company or any Subsidiary of the Company, (iv) any entity holding Common Shares for or pursuant to the terms of any such employee benefit or compensation plan, or (v) any of Eastbourne Capital Management, L.L.C. (solely in connection with
investment power exercisable by Eastbourne Capital Management, L.L.C. with respect to Common Shares managed for Black Bear Offshore Master Fund, L.P., a Cayman Islands limited partnership, Black Bear Fund I, L.P., a California limited partnership,
and Black Bear Fund II, L.L.C., a California limited liability company), Black Bear Offshore Master Fund, L.P., a Cayman Islands limited partnership, Black Bear Fund I, L.P., a California limited partnership, Black Bear Fund II, L.L.C., a California
limited liability company, and Richard J. Barry (collectively the “Eastbourne Entities”), but only so long as none of the Persons described in this clause (v), together with any of their respective Affiliates or Associates, either
individually or collectively, is the Beneficial Owner of 30% or more of the Common Shares then outstanding (the “Eastbourne Percentage”); provided, however, that effective at 11:59 pm Eastern Time on the date (the “Measurement
Date”) on which the Company publicly announces that it has received approval from the U.S. Food and Drug Administration to market the Company’s product candidate that is known as Telcyta as of the date of this Agreement, the Eastbourne
Percentage would be automatically, and without further action or approval of the Company or any of the Eastbourne Entities or their respective Affiliates or Associates, amended to be the greater of (a) 25% or (b) the percentage (not to
exceed 30%) of the Beneficial Ownership of the Common Shares outstanding collectively held by the Eastbourne Entities, together with any of their respective Affiliates or Associates, either individually or collectively, as of the Measurement Date,
and (B) no Person shall become an “Acquiring Person” either (x) as the result of an acquisition of Common Shares by the Company which, by reducing the number of shares outstanding, increases the proportionate number of shares
beneficially owned by such Person to 20% (or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities) or more of the Common Shares then outstanding by reason of share purchases by the Company and shall, following written
notice from, or public disclosure by the Company of such share purchases by the Company, become the Beneficial Owner of any additional Common Shares without the prior consent of the Company and shall then Beneficially Own more than 20% (or the
Eastbourne Percentage then in effect with respect to the Eastbourne 

 Entities) of the Common Shares then outstanding, then such Person shall be deemed to be an
“Acquiring Person,” (y) as the result of the acquisition of Common Shares directly from the Company, provided, however that if a Person shall become the Beneficial Owner of 20% (or the Eastbourne Percentage then in effect with respect
to the Eastbourne Entities) or more of the Common Shares then outstanding by reason of share purchases directly from the Company and shall, after that date, become Beneficial Owner of any additional Common Shares without the prior written consent of
the Company and shall then Beneficially Own more than 20% (or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities) of the Common Shares then outstanding, then such Person shall be deemed to be an “Acquiring
Person” or (z) if the Board of Directors determines in good faith that a Person who would otherwise be an “Acquiring Person,” as defined pursuant to the foregoing provisions of this paragraph (a), has become such inadvertently,
and such Person divests, as promptly as practicable (as determined in good faith by the Board of Directors), but in any event within five Business Days, following receipt of written notice from the Company of such event, of Beneficial Ownership of a
sufficient number of Common Shares so that such Person would no longer be an Acquiring Person, as defined pursuant to the foregoing provisions of this paragraph (a), then such Person shall not be deemed to be an “Acquiring Person” for any
purposes of this Agreement; provided, however, that if such Person shall again become the Beneficial Owner of 20% (or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities) or more of the Common Shares then outstanding,
such Person shall be deemed an “Acquiring Person,” subject to the exceptions set forth in this Section 1(a).” 
 3.  All references in the Rights Agreement to “20%” shall be followed by “(or the Eastbourne Percentage then in effect with respect to the Eastbourne Entities)”, other than in the definition of
“Acquiring Person” set forth in Section 1(a), which is amended as provided above. 
 4.  Except as expressly
set forth herein, this Second Amendment shall not alter, modify, amend or in any affect any of the terms, conditions, covenants, obligations or agreements contained in the Rights Agreement, all of which are ratified and affirmed in all respects and
shall continue to be in full force and effect. 
 5.  If any term, provision, covenant or restriction of this Second
Amendment is held by a court of competent jurisdiction or other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Second Amendment shall remain in full force and effect and
shall in no way be affected, impaired or invalidated. 
 6.  This Second Amendment shall be deemed to be a contract made
under the laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with the laws of such State applicable to contracts to be made and performed entirely within such State. 
 7.  This Second Amendment may be executed in any number of counterparts and each of such counterparts shall for all purposes be deemed
to be an original, and all such counterparts shall together constitute but one and the same instrument. 
 [SIGNATURE PAGE TO FOLLOW]

 IN WITNESS WHEREOF, the parties herein have caused
this Second Amendment to be duly executed and attested, all as of the date and year first above written. 
  

			
	TELIK, INC.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	COMPUTERSHARE SHAREHOLDER SERVICES, INC.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	COMPUTERSHARE TRUST COMPANY, N.A.
		
	By:	 	  

	Name:	 	
	Title:

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