Document:

<PAGE>   1

                                                                     Exhibit 4.8

                            STOCK PURCHASE AGREEMENT

CIMA Labs Inc.
10000 Valley View Road
Eden Prairie, Minnesota  55344

The undersigned (the "Investor"), hereby confirms its agreement with you as
follows:

1.   This Stock Purchase Agreement (the "Agreement") is made as of the date set
     forth below between CIMA Labs, Inc., a Delaware corporation (the
     "Company"), and the Investor.

2.   The Company has authorized the sale and issuance of up to 1,200,000 shares
     (the "Shares") of common stock of the Company, $.01 par value per share
     (the "Common Stock"), subject to adjustment by the Company's Board of
     Directors, to certain investors in a private placement (the "Offering").

3.   The Company and the Investor agree that the Investor will purchase from the
     Company and the Company will issue and sell to the Investor 300,000 shares,
     for a purchase price of $19.00 per share, or an aggregate purchase price of
     $5,700,000, pursuant to the Terms and Conditions for Purchase of Shares
     attached hereto as Annex I and incorporated herein by this reference as if
     fully set forth herein. Unless otherwise requested by the Investor,
     certificates representing the Shares purchased by the Investor will be
     registered in the Investor's name and address as set forth below.

4.   The Investor represents that, except as set forth below, (a) it has had no
     position, office or other material relationship within the past three years
     with the Company or its affiliates, (b) neither it, nor any group of which
     it is a member or to which it is related, beneficially owns (including the
     right to acquire or vote) any securities of the Company and (c) it has no
     direct or indirect affiliation or association with any NASD member.
     Exceptions:

                                      none
      --------------------------------------------------------------------------

          (If no exceptions, write "none." If left blank, response will
                            be deemed to be "none.")

Please confirm that the foregoing correctly sets forth the agreement between us
by signing in the space provided below for that purpose.

                                        DATED AS OF:  March 13, 2000

                                        Franklin Biotechnology Discovery Fund
                                        -------------------------------------
                                        INVESTOR
                                        By:    /s/ Murray L. Simpson
                                             -----------------------
                                        Print Name:  Murray L. Simpson
                                        Title:  Vice President
                                        Address:  777 Mariners Island Boulevard,
                                        San Mateo, California  94404

AGREED AND ACCEPTED:
CIMA LABS INC.

By:    /s/ John M. Siebert
       -------------------
       John M. Siebert

Title: President and Chief Executive Officer<PAGE>   1

                                                                     EXHIBIT 4.9

                            STOCK PURCHASE AGREEMENT

CIMA Labs Inc.
10000 Valley View Road
Eden Prairie, Minnesota  55344

The undersigned (the "Investor"), hereby confirms its agreement with you as
follows:

1.   This Stock Purchase Agreement (the "Agreement") is made as of the date set
     forth below between CIMA Labs, Inc., a Delaware corporation (the
     "Company"), and the Investor.

2.   The Company has authorized the sale and issuance of up to 1,200,000 shares
     (the "Shares") of common stock of the Company, $.01 par value per share
     (the "Common Stock"), subject to adjustment by the Company's Board of
     Directors, to certain investors in a private placement (the "Offering").

3.   The Company and the Investor agree that the Investor will purchase from the
     Company and the Company will issue and sell to the Investor 600,000 shares,
     for a purchase price of $19.00 per share, or an aggregate purchase price of
     $11,400,000, pursuant to the Terms and Conditions for Purchase of Shares
     attached hereto as Annex I and incorporated herein by this reference as if
     fully set forth herein. Unless otherwise requested by the Investor,
     certificates representing the Shares purchased by the Investor will be
     registered in the Investor's name and address as set forth below.

4.   The Investor represents that, except as set forth below, (a) it has had no
     position, office or other material relationship within the past three years
     with the Company or its affiliates, (b) neither it, nor any group of which
     it is a member or to which it is related, beneficially owns (including the
     right to acquire or vote) any securities of the Company and (c) it has no
     direct or indirect affiliation or association with any NASD member.
     Exceptions:

                                       none
      --------------------------------------------------------------------------

        (If no exceptions, write "none." If left blank, response will be
                             deemed to be "none.")

Please confirm that the foregoing correctly sets forth the agreement between us
by signing in the space provided below for that purpose.

                                        DATED AS OF:  March 13, 2000

                                        Franklin Small Cap Growth Fund
                                        INVESTOR

                                        By:    /s/ Murray L. Simpson
                                             -----------------------
                                        Print Name:  Murray L. Simpson
                                        Title:  Vice President
                                        Address:  777 Mariners Island Boulevard,
                                        San Mateo, California  94404

AGREED AND ACCEPTED:
CIMA LABS INC.
By:    /s/ John M. Siebert
       -------------------
       John M. Siebert

Title: President and Chief Executive Officer<PAGE>   1
                                                                   Exhibit 4.5

                         COUNTERSIGNED AND REGISTERED
                                  AMERICAN STOCK TRANSFER & TRUST COMPANY
                                                                  TRANSFER AGENT
                                                                   AND REGISTRAR
                         BY

                                                            AUTHORIZED SIGNATURE

                              [CELLOMICS(TM) LOGO]

                                CELLOMICS, INC.
              INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE

THIS CERTIFICATE IS TRANSFERABLE                               SEE REVERSE FOR
        IN NEW YORK, N.Y.                                    CERTAIN DEFINITIONS
                                                        CUSIP

THIS CERTIFIES THAT

IS THE OWNER OF

         FULLY PAID AND NON-ASSESSABLE COMMON SHARES $.01 PAR VALUE OF
                                CELLOMICS, INC.
(hereinafter called the "Corporation"), transferable on the books of the
Corporation by the holder hereof in person or by duly authorized attorney upon
surrender of this certificate property endorsed. This certificate and the shares
represented hereby are issued and shall be held subject to all of the
provisions of the Articles of Incorporation and the Bylaws of the Corporation,
as restated or amended, or as same may be restated or amended hereafter (a copy
of which is on file with the Transfer Agent and Co. Transfer Agent), to all of
which the holder hereof by acceptance hereof agrees and assents.
This certificate is not valid until countersigned and registered by the Transfer
Agent and Registrar.
WITNESS the facsimile seal of the Corporation and the facsimile signatures of
its duly authorized officers.

   Dated
                           [CELLOMICS SEAL]
   /s/ LEROY METZ                                      /s/ D. LANSING TAYLOR
           SECRETARY                                     PRESIDENT AND CHIEF
                                                          EXECUTIVE OFFICER

<PAGE>   2
                                CELLOMICS, INC.

     THE CORPORATION WILL FURNISH WITHOUT CHARGE TO EACH STOCKHOLDER WHO SO
REQUESTS THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE, PARTICIPATING,
OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OR SERIES THEREOF OF
THE CORPORATION AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH
PREFERENCES AND/OR RIGHTS. SUCH REQUEST MAY BE MADE TO THE TREASURER OF THE
CORPORATION, OR TO THE TRANSFER AGENT OF THE CORPORATION.

     The following abbreviations, when used in the inscription on the face of
this certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

<TABLE>
<S>                                          <C>
TEN COM -- as tenants in common              UNIF GIFT MIN ACT --             CUSTODIAN
TEN ENT -- as tenants by the entireties                          -------------         --------------
JT TEN  -- as joint tenants with right of                           (Cust)                 (Minor)
           survivorship and not as tenants                       under Uniform Gifts to Minors
           in common                                             Act
                                                                    ---------------------------------
                                                                                  (State)
                                             UNIF TRF MIN ACT --             CUSTODIAN (until age   )
                                                                 ------------                    ---
                                                                  (Cust.)

                                                                 ------------under Uniform Transfers
                                                                    (Minor)

                                                                 to Minors Act
                                                                              ----------------------
                                                                                       (State)
</TABLE>

    Additional abbreviations may also be used though not in the above list.

  FOR VALUE RECEIVED,___________________hereby sell, assign and transfer unto

PLEASE INSERT SOCIAL SECURITY OR OTHER
    IDENTIFYING NUMBER OF ASSIGNEE
______________________________________

________________________________________________________________________________

________________________________________________________________________________
 (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

________________________________________________________________________________

________________________________________________________________________________

__________________________________________________________________________Shares
of common stock represented by the within Certificate, and do hereby irrevocably
constitute and appoint__________________________________________________Attorney
to transfer the said stock on the books of the within named Corporation with
full power of substitution in the premises.

Date_____________________________________

                              X ________________________________________________

                              X ________________________________________________
                         NOTICE THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND
                                WITH THE NAMES(S) AS WRITTEN UPON THE FACE OF
                                THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT
                                ALTERATION OR ENLARGEMENT OR ANY CHANGE
                                WHATEVER.

Signature(s) Guaranteed

By______________________________________________
THE SIGNATURE(S) MUST BE GUARANTEED BY AN
ELIGIBLE GUARANTOR INSTITUTION (BANKS,
STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND
CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED
SIGNATURE GUARANTEE MEDALLION PROGRAM) PURSUANT
TO SEC RULE 17Ad-15.

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