Document:

Loan and Security Modification Agreement, dated March 17,2009

 Exhibit 10.40 
 LOAN AND SECURITY MODIFICATION AGREEMENT 
 This Loan and Security Modification Agreement is entered
into as of March 17, 2009, by and between Kana Software, Inc. (the “Borrower”) and Bridge Bank, National Association (“Lender”). 
 1. DESCRIPTION OF EXISTING INDEBTEDNESS: Among other indebtedness which may be owing by Borrower to Lender, Borrower is indebted to Lender pursuant to, among other documents, a Second Amended and Restated Loan and Security Agreement,
dated March 28, 2008 by and between Borrower to Lender, as may be amended from time to time (the “Loan and Security Agreement”). Capitalized terms used without definition herein shall have the meanings assigned to them in the Loan and
Security Agreement. 
 Hereinafter, all indebtedness owing by Borrower to Lender shall be referred to as the “Indebtedness” and the Loan and
Security Agreement and any and all other documents executed by Borrower in favor of Lender shall be referred to as the “Existing Documents.” 
 2.
ACKNOWLEDGEMENT OF DEFAULTS. 
 Borrower hereby acknowledges that as of the date hereof, the following Events of Default (the
“Existing Defaults”) have occurred and remain uncured under the Loan and Security Agreement: 
  

	 	1)	For the months ended November 30, 2008 and December 31, 2008, failure to maintain the monthly Asset Coverage Ratio of at least 2.00 to 1.00, as required in
Section 6.7, entitled “Asset Coverage Ratio”. 

  

	 	2)	For the month ended January 31, 2009, failure to maintain the monthly Asset Coverage Ratio of at least 2.00 to 1.00, as required in Section 6.7, entitled “Asset
Coverage Ratio”. 

  

	 	3)	For the quarter ended December 31, 2008, failure to maintain the quarterly Profitability of not less than One Dollar ($1.00), as required in Section 6.8, entitled
“Profitability”. 

  

	 	4)	For the quarter ended December 31, 2008, failure to maintain a Debt Service Coverage ratio of at least 1.50:1.00, as required in Section 6.9, entitled “Debt
Service Coverage”. 

 3. WAIVER OF CERTAIN EXISTING DEFAULTS. 
 Lender hereby waives the Existing Defaults as described in Subsections 1), 3), and 4) of Section 2 hereabove, only so long as Borrower complies in
all respects with the Loan and Security Agreement and with the Existing Documents beginning with the month ended February 28, 2009 and the quarter ending March 31, 2009, as applicable. Borrower remains in default with respect to the Asset
Coverage Ratio for the month ended January 31, 2009. 
 This waiver does not constitute a continuing waiver or a course of conduct by
waiving this or any other provisions of the Loan and Security Agreement. 
 4. DESCRIPTION OF CHANGE IN TERMS. 
  

	 	1)	The following defined term in Section 1.1, entitled “Definitions” is hereby amended to read as follows, effective as of March 17, 2009:

 “Prime Rate” means the greater of i) 4.00% per annum, or (ii) the variable rate of interest, per annum,
most recently announced by Lender as its “Prime Rate”, whether or not such announced rate is the lowest rate available from Lender. 
  

	 	2)	The following Subsections in Section 2.3(a), entitled “Interest Rates”, are hereby amended to read as follows, effective as of March 17, 2009:

  

	 	(i)	Advances. Except as set forth in Section 2.3(b), the Advances shall bear interest, on the outstanding Daily Balance thereof, at a rate equal to two and one half of one
percent (2.50%) above the Prime Rate; provided however, such interest rate shall be reduced to one and one quarter of one percent (1.25%) above the Prime Rate upon Bank’s receipt of evidence showing Borrower has been in compliance in
all respects with the Loan and Security Agreement and with the Existing Documents for two consecutive quarters. 

  

 1 

	 	(ii)	Existing Equipment Advance, Except as set forth in Section 2.3(b), the Existing Equipment Advances shall bear interest, on the outstanding Daily Balance thereof, at a
rate equal to two and one half of one percent (2.50%) above the Prime Rate; provided however, such interest rate shall be reduced to one and one quarter of one percent (1.25%) above the Prime Rate upon Bank’s receipt of evidence
showing Borrower has been in compliance in all respects with the Loan and Security Agreement and with the Existing Documents for two consecutive quarters. 

  

	 	(iii)	Equipment Loan B Advances. Except as set forth in Section 2.3(b), the Equipment Loan B Advances shall bear interest, on the outstanding Daily Balance thereof, at a rate
equal to two and one half of one percent (2.50%) above the Prime Rate; provided however, such interest rate shall be reduced to one and one quarter of one percent (1.25%) above the Prime Rate upon Bank’s receipt of evidence showing
Borrower has been in compliance in all respects with the Loan and Security Agreement and with the Existing Documents for two consecutive quarters. 

 5. RESTRICTION OF ADVANCES UNDER THE REVOLVING FACILITY. Until such time Borrower is in compliance in all respects with the Loan and Security Agreement and with the Existing Documents, Borrower shall not request, and Lender shall not
make any Advances under the Revolving Facility. 
 6. CONSISTENT CHANGES. The Existing Documents are each hereby amended wherever necessary to reflect
the changes described above. 
 7. PAYMENT OF WAIVER FEE. Borrower shall pay Lender a fee in the amount of $20,000 (the “Waiver Fee”) plus
all out-of-pocket expenses. 
 8. NO DEFENSES OF BORROWER/GENERAL RELEASE. Borrower agrees that, as of this date, it has no defenses against the
obligations to pay any amounts under the Indebtedness. Each of Borrower and Guarantor (each, a “Releasing Party”) acknowledges that Lender would not enter into this Loan and Security Modification Agreement without Releasing Party’s
assurance that it has no claims against Lender or any of Lender’s officers, directors, employees or agents. Except for the obligations arising hereafter under this Loan and Security Modification Agreement, each Releasing Party releases Lender,
and each of Lender’s and entity’s officers, directors and employees from any known or unknown claims that Releasing Party now has against Lender of any nature, including any claims that Releasing Party, its successors, counsel, and
advisors may in the future discover they would have now had if they had known facts not now known to them, whether founded in contract, in tort or pursuant to any other theory of liability, including but not limited to any claims arising out of or
related to the Agreement or the transactions contemplated thereby. Releasing Party waives the provisions of California Civil Code section 1542, which states: 
 “A general release does not extend to claims which the creditor does not know or suspect to exist in his favor at the time of executing the release, which if known by him must have materially affected his settlement with the
debtor.” 
 The provisions, waivers and releases set forth in this section are binding upon each Releasing Party and its shareholders, agents,
employees, assigns and successors in interest. The provisions, waivers and releases of 

  

 2 

 
this section shall inure to the benefit of Lender and its agents, employees, officers, directors, assigns and successors in interest. The provisions of this
section shall survive payment in full of the Obligations, full performance of all the terms of this Loan and Security Modification Agreement and the Agreement, and/or Lender’s actions to exercise any remedy available under the Agreement or
otherwise. 
 9. CONTINUING VALIDITY. Borrower understands and agrees that in modifying the existing Indebtedness, Lender is relying upon
Borrower’s representations, warranties, and agreements, as set forth in the Existing Documents. Except as expressly modified pursuant to this Loan and Security Modification Agreement, the terms of the Existing Documents remain unchanged and in
full force and effect. Lender’s agreement to modifications to the existing Indebtedness pursuant to this Loan and Security Modification Agreement in no way shall obligate Lender to make any future modifications to the Indebtedness. Nothing in
this Loan and Security Modification Agreement shall constitute a satisfaction of the Indebtedness. It is the intention of Lender and Borrower to retain as liable parties all makers and endorsers of Existing Documents, unless the party is expressly
released by Lender in writing. No maker, endorser, or guarantor will be released by virtue of this Loan and Security Modification Agreement. The terms of this paragraph apply not only to this Loan and Security Modification Agreement, but also to any
subsequent Loan and Security modification agreements. 
 10. CONDITIONS. The effectiveness of this Loan and Security Modification Agreement is
conditioned upon payment of the Waiver Fee. 
 11. COUNTERSIGNATURE. This Loan and Security Modification Agreement shall become effective only when
executed by Lender, Borrower, and Guarantor. 
  

									
	BORROWER:	  		 	LENDER:
			
	KANA SOFTWARE, INC.	  		 	BRIDGE BANK, NATIONAL ASSOCIATION
					
	By:	 	 /s/ Michael J. Shannahan
	  		 	By:	 	 /s/ Dan Pistone

	Name:	 	 Michael J. Shannahan
	  		 	Name:	 	 Dan Pistone

	Title:	 	 Chief Financial Officer
	  		 	Title:	 	 Senior Vice President

 Guarantor consents to the modifications to the Indebtedness pursuant to this Loan and Security Modification
Agreement, hereby ratifies the provisions of the Guaranty and confirms that all provisions of that document are in full force and effect.First Amendment to Sublease Agreement - Titan Pharmaceuticals, Inc.

 Exhibit 10.89 
 FIRST AMENDMENT TO SUBLEASE 
 THIS FIRST
AMENDMENT TO SUBLEASE (this “First Amendment”) is made as of the 8th day of April, 2009 by and between TITAN PHARMACEUTICAL, INC., a
Delaware corporation (hereinafter “Sublessor”), and ANESIVA, INC., a Delaware corporation (hereinafter “Sublessee”). 
 WITNESSETH 
 WHEREAS, Sublessor and Sublessee entered into that certain Sublease dated as of March 27, 2009 (the
“Sublease”) with respect to certain premises located on the fifth floor of that building commonly known and designated as 400 Oyster Point Boulevard, South San Francisco, California (the “Subleased Premises”); and 
 WHEREAS, the City of South San Francisco has fully and finally determined the suite designation to be used to identify the Subleased Premises; and

 WHEREAS, Sublessor and Sublessee desire to amend the Sublease to incorporate such governmentally mandated suite designation. 

NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth herein, the parties agree as follows: 
 1. All capitalized terms used herein and not otherwise defined herein shall have the meanings as ascribed to them in the Sublease. 
 2. The Sublease shall be and hereby is amended to delete any and all references to words and numbers “Ste. 503” and “Suite 503” as
currently set forth therein and to replace such words and numbers in each instance with the words and numbers “Suite 502” so as to reflect that the Subleased Premises is and shall be known and designated as Suite 502 pursuant to the
mandate of the City of South San Francisco. This substitution of the words and numbers “Suite 502” shall include, without limitation, substitution of such words and numbers in the notice address of Sublessee under the Sublease. 

3. Except as expressly amended and modified hereby, the Sublease shall continue unmodified and in full force and effect and is hereby ratified and
confirmed. This First Amendment may be executed in counterpart, which, taken together, shall constitute a single original instrument. Electronic and/or facsimile signatures on this First Amendment shall be deemed as effective and enforceable as
original signatures; provided, however, each party shall be obligated, on the request of the other party, to provide such original signature promptly if and when so requested. 
 [THE REMAINDER OF THIS PAGE IS INTENTIONALLY LEFT BLANK] 

 IN WITNESS WHEREOF, the parties hereto have duly executed and delivered this First Amendment on the day
and year written below. 
  

									
		 		 	SUBLESSOR:
			
		 		 	TITAN PHARMACEUTICALS, INC.
			
	Attest:	 		 	
				
	 	 		 	By:	 	/s/ Robert Farrell
		 		 		 	Name:	 	Robert Farrell
		 		 		 	Title:	 	President & CEO
		 		 		 	Date:	 	4/8/09
			
		 		 	SUBLESSEE:
			
		 		 	ANESIVA, INC.
			
	Attest:	 		 	
				
	 	 		 	By:	 	/s/ Michael Kranda
		 		 		 	Name:	 	Michael Kranda
		 		 		 	Title:	 	President & CEO
		 		 		 	Date:	 	__________________

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