Document:

Document

Neoleukin Therapeutics, Inc.
1616 Eastlake Ave E Suite 360
Seattle, WA 98102
EIN: 83-2585260

Exhibit 10.23

PURCHASE ORDER

P.O. # 20201118-001 RIGAKU 
DATE:  18  NOVEMBER 2020

									
	VENDOR:
RIGAKU AMERICAS CORPORATION
9009 New Trails Drive
The Woodlands, TX 77381-5209 (281)362-2300
	SHIP TO:
Neoleukin Therapeutics, Inc. 188 E BLAINE ST SUITE 450
SEATTLE, WA 98102
(206)604-0724
	BILL TO:
Neoleukin Therapeutics, Inc. 1616 Eastlake Avenue East Suite 360
Seattle, WA 98102 

COMMENTS OR SPECIAL INSTRUCTIONS:

						
	REQUISITIONER	
	ACCOUNT NUMBER	
	QUOTATION NUMBER	PX28752rev1
	TAX STATUS	Taxable
	PAYMENT TERMS	Net 30 days

															
	CATALOG NUMBER	DESCRIPTION	UNIT PRICE
	QUANTITY	EXT. PRICE
		XtaLAB Synergy-R diffractometer system

See quotation PX28752rev1 below for details
	

$792,069.00
	

1
	

$792,069.00

				SUBTOTAL	$792,069.00
				SALES TAX	
				TOTAL DUE	

            						
	TO:     Neoleukin Therapeutics, Inc.
            1616 Eastlake Ave E
            Seattle, WA 98102	DATE:              November 19, 2020
VALIDITY:     60 days
DELIVERY:    5 – 6 months ARO
SHIPMENT:    FOB Destination to
                          Customer’s loading dock                                Risk of loss passes to Buyer at FOB point.
TITLE:           Title transfers to Buyer at FOB point.

	PHONE:
FAX:
EMAIL:	INSTALLATION:         Included
WARRANTY:               One Year
PAYMENT TERMS:    50% on Dec. 15, 2020, 30% on shipment, 20% on installation, Net 30

XtaLAB Synergy-R (Cu) HyPix-Arc 150° Curved HPC Detector The XtaLAB Synergy-R diffractometer combines leading edge components and user-inspired software. The foundation of the system is the PhotonJet-R source which integrates the second generation true microfocus MicroMax 007HF rotating anode generator with a specialized confocal MaxFlux optic to provide a uniquely small focal spot. The intense, monochromatic beam from the PhotonJet-R optimizes signal-to-noise for the small crystals used in today’s crystallography laboratories. The XtaLAB Synergy- R system also includes a new kappa goniometer that features a unique telescopic two-theta arm to provide total flexibility for your diffraction experiment. The XtaLAB Synergy-R is compatible with a wide range of CCD and hybrid photon counting (HPC) detectors to allow you to design the best diffractometer for your samples. 

Notes for Purchasing Manager:

Taxes (for: Arizona, California, Colorado, Connecticut, Florida, Georgia, Hawaii, Illinois, Indiana, Maryland, Massachusetts, Michigan, New Jersey, New York, North Carolina, Pennsylvania, South Dakota, Tennessee, Texas, Utah, Virginia, Washington, Wisconsin) will be added to invoice if applicable. If Buyer claims tax exempt status, Buyer agrees to provide Rigaku (Seller) with a tax exemption certificate acceptable to local taxing authorities in the jurisdiction concerned.

Seller offers to sell to Buyer, and Buyer agrees to purchase from Seller, the goods and services described below, subject to the terms and conditions stated on the face of this Quotation and Seller’s standard terms and conditions, attached. Seller hereby objects to any additional or different terms stated in Buyer’s request for quotation, purchase order, or any other document of Buyer. Any modification of these terms of sale must be specifically agreed to in writing by Seller. This contract is binding upon Seller’s receipt of Buyer’s Purchase Order for same. Please address Purchase Order to Rigaku Americas Corporation to the address at the bottom of this page, or email to purchaseorder@rigaku.com.

Payment terms beyond Net 30 days are subject to a 7.5% interest charge and/or loss of applicable discounts. Preferred method of payment is check or ACH payments. Credit card purchases are limited to $20,000. This contract is binding upon Seller’s receipt of Buyer’s Purchase Order for same.

Prices are listed in USD.
Prices are based on quoted payment terms.
Prices and specifications subject to change without notice.
Page 1 of 6

Quotation validity subject to compliance with US Government export regulations for Analytical X-ray instrumentation.

Total system price includes delivery, assembly, installation, 12 months on-site labor and parts warranty (excluding consumables), and on-site basic operation/maintenance training.

Inside delivery is not included. If inside delivery is required, an additional charge will apply. When accepting delivery, please note on transport documents any shortage or damage, and advise Rigaku immediately at installcoordinator@rigaku.com.

Rigaku
/s/ Eric Reinheimer
Eric Reinheimer, Ph.D., MRSC Western Regional Account Manager Rigaku Oxford Diffraction SBU

Accepted by:
/s/ Robert Ho
Robert Ho, CFO    
Neoleukin Therapeutics, Inc. 
Page 2 of 6

												
	ITEM	QTY
	DESCRIPTION
	TOTAL
	1
	1
	XtaLAB Synergy-R diffraction System Includes:
•4-circle kappa goniometer with unique telescopic two-theta arm
•Large radiation protection cabinet interlocked for safety
•Bright cabinet and sample lighting with electronically controlled intensity
•Control computer – Windows – 24” monitor
•CrysAlisPro Multi-user/multi-site software license that is easy to use and can be fully automated from data collection through data reduction and processing
•Cryo Mount
PhotonJet-R (Cu) includes the world’s most popular rotating anode generator with a specialized Confocal MaxFlux optic featuring;
•Loading: 1200 W
•Copper anode: direct drive, one supplied (4364F501)
•Effective focal size: approximately 70 microns
•Filament: 1 box of 3 filaments is provided
•CMF optic, housing and all necessary parts for coupling to the MM007-HF anode
•Optimal performance with samples of 300 microns or smaller
•Remote control slits for divergence adjustment from 9 mR to 1 mR.
	
		

1

	2
	1
	Refrigerated heat exchanger (water cooled)
Close temperature control to ± .1°C
	
	3
	1
	Filaments: (3 per box) 0.1 x 1 mm
	
	4
	1
	PhotonJet-R (Cu) direct drive rotating anode assembly, Cu target	
	5
	1
	HyPix-Arc 150° Curved Hybrid Photon Counting (HPC) Detector Features:
•Minimal reflection profile distortion
•All reflections measured under the same conditions
•Capture more photons per image with 150° of 2θ coverage
•70 Hz readout for fast data collection
•Scintillator free design
•100 mu pixels
	
	6
	1
	XtaLAB Synergy Flow Robot
The XtaLAB Synergy Flow robotic system allows you to now take full advantage of the high performance of your system by incorporating a 6- axis Universal Robot which provides unattended data acquisition, enhanced productivity, and standardized workflow to your crystallographic research environment. A XtaLAB Synergy Flow system can be used as part of a lab workflow and sample submission protocol that minimizes human contact.
	

Page 3 of 6

												
	ITEM	QTY
	DESCRIPTION
	TOTAL
	6
cont
		Features:
•Unattended data collection of up to 48 samples is carried out without users present in the laboratory. This allows higher productivity where the system is always collecting data with a user is not present, such as overnight or over the weekend.
•A unique X-ray safe dewar drawer system with a side loading port allows pucks to be loaded without opening the enclosure door and without interrupting data collection.
•The Intelligent Goniometer Head (iGH), a motorized marvel provides automated sample centering as fast as 6 seconds on a dual camera system, the standard for our robotic instruments. Manual and point and click control are also available for fine-tuning centering or targeting a specific feature or part of the sample.
•Force free end effector envelopes the sample in liquid nitrogen and transports it without applying force to the pin for high reliability.
•Samples are stored in an LN2 dewar with a capacity of 48 samples stored in 3 Uni-pucks. Dewar accessories include a bar code reader, a defrost system, rotatable lid, level sensor and automatic LN2 dosing system. Accepted pins include the ALS standard from ALS and the SPINE standard from EMBL.
Includes:
•Built in UR3 6-axis Universal Robot
•Side loading dewar with (3) Uni-pucks
•Intelligent Goniometer Head with dual camera optical sample alignment
•CrysAlisPro software interface for robot operation, sample queuing, sample sorting, and crystal judgements.
	
	7
	1
	Deluxe Starter Kit for XtaLAB Synergy Flow Robot

Includes:
•(7) UniPucks, UniPuck Took Kit, UniPuck Rack Kit
•Spines and CryoLoops
•Pin set and tong
•Dry Shipper
•Vessel Dewar and Dewar Flask
	
	8
	1
	CSCOBRA: The non-liquid Cryostream designed for use in labs where
	
			access to liquid nitrogen is logistically difficult to achieve or prohibitively
			expensive.
			•Temperature range of 80–400K

		1
	House N2 kit
		1
	Cobra Table Stand for XtaLAB Synergy-R
	9
	1
	Applications Training at the Customer’s Site
•Applications training at customer’s site (up to 3 days) by a Rigaku Applications Scientist.
•Travel and expenses are included.
•Training must be completed within three months of system installation.
	
	Total for Items 1 – 9	$989,781
	Less Package Discount	-$197,712
	Discounted Total for Items 1 – 9	$792,069

Page 4 of 6

NOTES:
1.Due to some state and/or country regulations, a radiation leakage survey (by use of a Radiation Meter and Paddle) must be performed upon completion of x-ray source equipment. The customer is responsible for providing a Radiation Meter and Paddle if such survey for registration of x-ray source equipment is required for operation. To avoid any delays in registration of operation, please check with your institution’s Radiation Safety Officer (RSO), if available, or state and/or country web sites for specific Radiation Safety Regulations prior to installation. If your institution does not currently possess  a Radiation Meter and Paddle and one is required, then one may be purchased from Rigaku.
2.User agrees to provide internet access to control computers with ports available for TeamViewer. Failure to comply may result in charges for support.
3.Transformers and/or UPS system are not included with this quotation.
4.PhotonJet-R (Cu) anode must be returned to Rigaku for re-balancing. Shipping, insurance and duties (if applicable) to and from RAC are the responsibility of Buyer.

ACCEPTANCE CRITERIA:
The equipment shall be deemed acceptable after complete installation of the x-ray system and when the following performance specifications have been met.

1.Continual operation of the XtaLAB Synergy-R generator for seven (7) days. (Rigaku will not be on-site for the entire testing process.)
2.The successful data collection on a cytidine or ylid crystal to 0.83 Å to an R-merge of 3.5% or less and a crystallographic refinement to R1 = 3.5% or less.

												
	ITEM
	QTY
	DESCRIPTION
	TOTAL
	OPTIONS:
	A
	1
	XtalCheck-S In-Situ Well Plate Scanner Attachment (XTC-S) XtalCheck-S In-situ Well Plate Scanner Attachment to measure crystals or powders in well plates. This device is mountable on the omega axis of the goniometer and provides motorized X and Y to access all wells on a standard SBS format well plate, either full height or low profile plate types. Motion control is provided along the beam direction for centering and image focusing. An additional video microscope is provided over the collimator for video imaging the plate contents and crystal alignment for X-ray diffraction in-situ. The XtalCheck-S is fully integrated into CrysAlisPro software. It is easily added or removed by the user on demand.
Specifications:
•XtalCheck-S includes simple attachment to the Synergy Universal Kappa Goniometer
•Full accessibility to all sample wells, horizontally and vertically
•Includes XtalCheck-S software that provides for
◦Automated imaging of crystallization drops
◦X-ray data collection of single X-ray images or partial data sets
•In-Situ Video System
	$45,325

Page 5 of 6

Standard Terms and Conditions of Sale

This entire agreement supersedes any other oral and/or written communication on this subject. This document and any other documents specifically referred to as being a part hereof constitute the entire agreement on the subject matter and shall not be modified except in writing signed by both parties.

1.PRICE
Purchase price for each item of equipment is guaranteed until midnight Central Time on the date shown in the “Valid Until” block on page one. Prices designated as “List Prices” are subject to change without notice. Prices are stated in currency listed and do not include taxes of any kind.

2.TAXES & DUTIES
If Seller is required by law to collect taxes on any amount subject to this contract, Seller will include such taxes on each applicable invoice and those amounts shall be due on Buyer’s receipt of the invoice. If Buyer claims tax-exempt status, Buyer shall provide Seller a tax exemption certificate or other documentation acceptable to the appropriate taxing authority.

Unless otherwise stated, Buyer is solely responsible for all other taxes which Seller is not required by law to collect, and any other charges imposed on shipment of the purchased goods. Seller shall not be liable for any delay, loss, or indirect, special, liquidated, incidental, or consequential damages resulting from Buyer’s failure to timely pay amounts for which it is responsible.

Buyer is responsible for all duties including customs clearance charges, as applicable, outside of the United States and/or European Community, unless otherwise stated.

3.PAYMENT TERMS
Payment shall be made in accordance with the terms stated on page one of this contract. In the event that delivery is delayed at Buyer’s request, Buyer shall pay Seller 90% of the total contract amount on the original delivery date.

4.SOFTWARE LICENSE
Any software which is used in conjunction with the goods sold by this contract is transferred pursuant to a separate license agreement. Unless otherwise stated, the software is not  sold to Buyer and title to the software shall not pass to Buyer.

5.SHIPMENT
Shipment shall be made in accordance with the terms stated on page one. If inside  delivery is required and not expressly made a part of this contract, an additional charge will apply.

6.DELIVERY
Delivery shall be made in accordance with the terms stated on page one. In the event that delivery is delayed at Buyer’s request: (1) the equipment warranty period will commence on the original delivery date, and (2) Seller may store the goods at Seller’s facility or at such other location as Seller may choose at Seller’s sole discretion, and Buyer shall be responsible for all storage and incidental charges, regardless of the location at which the goods are stored.

7.TITLE
Buyer grants, and Seller retains, a security interest in all goods to secure payment therefore until all amounts due are paid, and Buyer agrees that it shall execute all documents necessary to secure such interest to Seller. Buyer shall not grant to any third party a security or other interest in the goods purchased pursuant to this contract which is in conflict with this paragraph.

8.EQUIPMENT WARRANTY
New goods, except expendables and supplies, are warranted against defects in materials and workmanship that materially affect the functionality of the goods until the earlier of twelve months from installation or fourteen months from delivery. Seller’s sole obligation under this warranty shall be to repair or replace defective components, including the cost of shipping parts and providing labor for installation, if applicable.

This warranty does not extend to other vendors’ products that are supplied to Buyer in conjunction with this contract. Those products are warranted by their respective manufacturer’s or vendor’s warranties in effect on the date of shipment to Buyer. Seller assigns to Buyer all rights it may have in such warranties. All warranties are contingent upon proper use of the goods and operation of the same within manufacturer’s specifications.

THIS WARRANTY IS EXPRESSLY IN LIEU OF ALL OTHER WARRANTIES, INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE, AND CONSTITUTES THE ONLY WARRANTY OF SELLER WITH RESPECT TO THE GOODS.

9.LIMITATION OF LIABILITY
Seller shall not be liable for any incidental, consequential or special damages, including, but not limited to any loss of business, income or profits, Buyer’s expenses for downtime, or for making up downtime, and any labor costs of Buyer related to the functioning of components covered by this Agreement. Seller’s liability on any claim of any kind of loss, injury, or allocated damages shall not exceed the fraction of the purchase price allocable to the component giving rise to such claim. The foregoing states the exclusive remedy of the Buyer and the exclusive liability of Seller. Seller agrees to indemnify and hold harmless Buyer and Buyer’s employees, officers, directors, affiliates, partially or wholly owned subsidiaries, agents, successors and assigns from all claims arising from or connected with the Seller’s performance of this contract, except for claims arising from the negligence, recklessness, or willful misconduct of Buyer or Buyer’s employees, officers, directors, affiliates, partially or wholly owned subsidiaries, agents, successors, and assigns. In the

event such a claim is asserted, Buyer will notify Seller immediately, and Seller’s counsel will represent Buyer. If Buyer elects to be represented through its own counsel in addition to Seller’s counsel, Buyer is responsible for its attorney’s fees and associated expenses.

10.DELAYS
If Seller suffers delay in performance due to any cause beyond its reasonable control including, but not limited to, acts of God, act or failure to act of government, act or omission of Buyer, war, fire, flood, strike or labor trouble, sabotage, or delay in obtaining from others suitable services, materials, components, equipment, or transportation, the time for Seller’s performance shall be extended a period of time equal to the period of the delay and its consequences. Seller will give the Buyer written notice within a reasonable time after  Seller becomes aware of any such delay.

11.SITE PREPARATION
Buyer shall prepare the installation site at Buyer’s expense; provide utilities in accordance with Seller’s pre-installation instructions and specifications; furnish uncrating, rigging, electrical (including step-up or step-down transformer if needed), plumbing, or other assistance, as required, and furnish materials and labor for connecting specified utilities to the purchased goods.

It is the Buyer’s sole responsibility to comply with X-ray registration, and satisfy all federal, state, and local X-ray radiation safety regulations with appropriate regulatory authorities.

12.INSTALLATION
On-site installation and instrumentation start up are provided by Seller at no additional charge unless otherwise stated in the quotation. Software applications training is offered per specifications and options in the body of the quotation.

13.CANCELLATION & DAMAGES
Buyer may not cancel or terminate this contract for convenience, nor may it direct suspension of Seller’s manufacture of the purchased goods or delivery of the same, except with Seller’s written consent and then only with tender of payment to Seller sufficient to compensate Seller for all direct and consequential costs incurred as a result of Buyer’s agreement to this contract and subsequent cancellation, plus a reasonable amount for profit. Buyer understands and agrees that the goods sold pursuant to this contract may be customized and not re-sellable to other customers, and that Seller’s loss due to Buyer’s cancellation may be the entire contract price and, in such cases, agrees that Seller may reasonably require the payment of 100% of the contract price notwithstanding Buyer’s desire to cancel.

14.OBJECTIONS TO CHANGES
Seller objects to any changes to these terms and conditions, which Buyer seeks to impose by means of terms stated in Buyer’s request for quotation, purchase order, or any other document of Buyer. Issuance of a purchase order hereto by Buyer constitutes Buyer’s assent to Seller’s terms and conditions. Acceptance of the quotation is expressly limited to the terms and conditions set forth herein. Any modification of these terms of sale must be specifically agreed to in writing by Rigaku.

15.AMENDMENT IN WRITING
These standard terms and conditions may not be amended except by a separate written agreement signed by both the Buyer and Seller. Alteration of the text of this document shall not constitute modification of the terms and conditions of this contract.

16.GOVERNING LAW
This contract shall be enforced pursuant to the law of the jurisdiction for the Seller’s office which issued this quotation, i.e. Texas, Massachusetts, Canada or the UK.

17.ASSIGNMENT
Buyer’s obligations pursuant to this contract may not be assigned without the express, written agreement of Seller.

18.SEVERABILITY
In the event that a court of competent jurisdiction shall hold any portion of this contract to be void or unenforceable, that portion of this contract shall be severed and the remainder shall remain in full force and effect.

19.TRADE COMPLIANCE TERMS/OBLIGATIONS
U.S. export controls regulate the shipment of U.S.-origin Rigaku products that are exported or reexported to foreign countries. If Buyer exports or reexports products or technology of
U.S. origin, or containing U.S. origin, it is the Buyer’s responsibility to ascertain its compliance obligations under the U.S. export laws and regulations, as well as any foreign export laws and regulations that may apply. The U.S. maintains economic sanctions against certain countries, including but not limited to, Cuba, Iran, North Korea, Sudan, and Syria. The export, reexport, sale, supply, or service, directly or indirectly, from the U.S. or by a U.S. person, wherever located, to any sanctioned countries is strictly prohibited without prior authorization by the U.S. Government. Buyer shall not sell, transfer, export or reexport Rigaku products to prohibited countries, or individuals listed on U.S. Government denied party lists, or for prohibited end-uses.

20.COMPLIANCE WITH THE FOREIGN CORRUPT PRACTICES ACT
Buyer acknowledges and agrees to comply with the U.S. Foreign Corrupt Practices Act, which prohibits the corrupt offer, payment, promise to pay or authorization of payment of anything of value, directly or indirectly, to a foreign official, political party or official thereof, or candidate for political office for the purpose of influencing any official act or inducing the official to use his influence to obtain or retain business.

Page 6 of 6Document

Exhibit 10.24

FIRST AMENDMENT TO LEASE
THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of November 5th, 2020, by and between ARE-SEATTLE NO. 28, LLC, a Delaware limited liability company (“Landlord”), and NEOLEUKIN THERAPEUTICS, INC., a Delaware corporation (“Tenant”).
RECITALS
A.    Landlord and Tenant are now parties to that certain lease dated as of December 23, 2019 (the “Lease”).  Pursuant to the Lease, Tenant leases certain premises consisting of approximately 33,300 rentable square feet (the “Premises”) located in that certain building located at 188 East Blaine Street, Seattle, Washington.  The Premises are more particularly described in the Lease.  Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease.
B.    Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the work letter attached to the Lease as Exhibit C (the “Work Letter”), as provided in this First Amendment.
NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows:
1.Rent Commencement Date.  As of the date of this First Amendment, Landlord and Tenant acknowledge agree that the defined term “Rent Commencement Date” set forth in the second paragraph of Section 2 of the Lease is hereby deleted and that the “Rent Commencement Date” under the Lease shall be February 1, 2021.
2.Implementation of Changes.  As of the date of this First Amendment, Section 4(b) of the Work Letter is hereby deleted in its entirety and replaced with the following:      
“If Landlord approves such Change, Tenant may cause the approved Change to be instituted.  If any TI Permit modification or change is required as a result of such Change, Tenant shall promptly provide Landlord with a copy of such TI Permit modification or change.”
3.Budget For Tenant Improvements.  As of the date of this First Amendment, the final sentence of Section 5(a) of the Work Letter is hereby deleted in its entirety.
4.Excess TI Costs.  As of the date of this First Amendment, Section 5(e) of the Work Letter is hereby deleted in its entirety and replaced with the following:
“(e) Excess TI Costs.  Landlord shall have no obligation to bear any portion of the cost of any of the Tenant Improvements except to the extent of the TI Allowance.  Tenant shall be responsible for any and all TI Costs in excess of the TI Allowance (“Excess TI Costs”).  The TI Allowance and Excess TI Costs are herein referred to as the “TI Fund.”  Notwithstanding anything to the contrary set forth in this Section 5(e), Tenant shall be fully and solely liable for TI Costs and the cost of Minor Variations in excess of the TI Allowance.”
4.    Payment of TI Costs. Notwithstanding anything to the contrary contained in the Work Letter, Landlord’s reimbursement of TI Costs under Section 5(f) shall be subject to the terms of Section 5(e).
        

5.    Tenant Server Room.  In connection with Tenant’s use and occupancy of the Premises, Tenant shall have the right, at Tenant’s sole cost and expense, to construct, pursuant to plans and specifications reasonably approved by Landlord, an enclosure of approximately 400 square feet in a location in the Building garage designated by Landlord, for the storage and operation of Tenant’s server equipment serving the Premises (the “Server Room”).  Notwithstanding anything to the contrary contained in the Lease, the construction of the Server Room shall constitute an Alteration under the Lease and shall be subject to the terms and conditions of Section 12 of the Lease.  Tenant shall have all of the obligations under the Lease with respect to the Server Room as though the Server Room were part of the Premises, excluding the obligation to pay Base Rent.  Tenant shall be responsible for any additional Utilities and/or Operating Expenses relating to the Server Room.  Tenant shall maintain appropriate records, obtain and maintain appropriate permits, insurance, implement reporting procedures, and take or cause to be taken all other actions necessary or required under applicable Legal Requirements in connection with the use of the Server Room.  Landlord shall have no obligation to make any repairs or other improvements to the Server Room and Tenant shall maintain the same, at Tenant’s sole cost and expense, in the same condition following the construction of the Server Room as though the same were part of the Premises.  Tenant shall, at Tenant’s sole cost and expense, surrender the Server Room at the expiration or earlier termination of the term of the Lease free of any debris and trash and free of any Hazardous Materials in accordance with the requirements of Section 28 of this Lease.
6.    Brokers.  Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively, “Broker”) in connection with the transaction reflected in this First Amendment and that no Broker brought about this transaction.  Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this First Amendment.
1.OFAC.  Tenant and all beneficial owners of Tenant are currently (a) in compliance with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of this Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions Evaders List, or the Sectoral Sanctions Identification List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules.
2.Miscellaneous.
i.This First Amendment is the entire agreement between the parties with respect to the subject matter contained in this First Amendment and supersedes all prior and contemporaneous oral and written agreements and discussions.  This First Amendment may be amended only by an agreement in writing, signed by the parties hereto.  Except as amended and/or modified by this First Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this First Amendment.  In the event of any conflict between the provisions of this First Amendment and the provisions of the Lease, the provisions of this First Amendment shall prevail.  Whether or not specifically amended by this First Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this First Amendment.
ii.This First Amendment is binding upon and shall inure to the benefit of the parties hereto, and their respective successors and assigns.
        

iii.This First Amendment may be executed in 2 or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.  Counterparts may be delivered via facsimile, electronic mail (including pdf or any electronic signature process complying with the U.S. federal ESIGN Act of 2000) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.  Electronic signatures shall be deemed original signatures for purposes of this First Amendment and all matters related thereto, with such electronic signatures having the same legal effect as original signatures. 
iv.Landlord and Tenant intend to be bound by this First Amendment and to deliver notarized signatures to this First Amendment, but are unable to deliver notarized signatures due to the Stay Home-Stay Healthy Proclamation by the Governor of the State of Washington, Proclamation 20 - 25.  Landlord and Tenant are delivering signatures without notary, with the intent to be fully bound by this First Amendment and will, as soon as reasonably possible, deliver notarized signatures for this First Amendment. Landlord and Tenant each acknowledge that the other party intends to rely on the statements in this First Amendment.
[Signatures are on the next page.]

        

IN WITNESS WHEREOF, the parties hereto have executed this First Amendment as of the dates set forth below.
TENANT:

NEOLEUKIN THERAPEUTICS, INC.,
a Delaware corporation

By: /s/ Jonathan G. Drachman        
Its: CEO

LANDLORD:

ARE-SEATTLE NO. 28, LLC, a Delaware limited liability company
By:     ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member
By:     ARE-QRS CORP., a Maryland corporation, general partner    
                       By: /s/ Gregory Kay
                          Its: Vice President RE Legal Affairs

                    

        

LANDLORD’S ACKNOWLEDGMENT

			
	A notary public or other officer completing this certificate verifies only the identity of the individual who signed the document to which this certificate is attached, and not the truthfulness, accuracy, or validity of that document.

STATE OF CALIFORNIA         )
                     ) §
County of                  ) 

On ______________, 2020, before me, ________________________________, a Notary Public, personally appeared ___________________________________ who proved to me on the basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument.

I certify under PENALTY OF PERJURY under the laws of the State of California that the foregoing paragraph is true and correct.

WITNESS my hand and official seal.

________________________________
Signature of Notary
(Affix seal here)

TENANT’S ACKNOWLEDGMENT
        

						
	STATE OF WASHINGTON
COUNTY OF KING
	

ss.

On this ____ day of ___________, 2020, before me personally appeared ___________________, to me known to be the Authorized Signatory of Amazon.com Services LLC, a Delaware limited liability company, that executed the within and foregoing instrument, and acknowledged the said instrument to be the free and voluntary act and deed of said corporation for the uses and purposes therein mentioned, and on oath stated that they were authorized to execute said instrument.
IN WITNESS WHEREOF, I have hereunto set my hand and affixed my official seal the day and year first above written.

			
	(Signature of Notary)

			
	(Legibly Print or Stamp Name of Notary)

Notary public in and for the State of Washington,
residing at     
My appointment expires

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00324-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00324-of-00352.parquet"}]]