Document:

First Amendment to the License Agreement

 EXHIBIT 10.22 
 AMENDMENT TO 
 EXCLUSIVE LICENSE AGREEMENT 
 This Amendment to the License and Supply Agreement (this “Amendment”) is made as of January 14, 2008 by and among Alphatec Spine, Inc., a
Delaware corporation with a principal place of business at 2051 Palomar Airport Road, Suite 100, Carlsbad, California 92008 (“Licensee”), Progressive Spinal Technologies LLC, a limited liability company organized under the laws of the
state of Delaware, with an address at 410 East Walnut Street, Suite #8, Perkasie, Pennsylvania 18944 (“Licensor”) and for purposes of Section 7.2 and Section 11.15 hereof only Alphatec Holdings, Inc., a Delaware corporation with a
principal place of business at 2051 Palomar Airport Road, Suite 100, Carlsbad, California 92008 (“Holdings”). Capitalized terms undefined herein shall have the meaning ascribed them in the Agreement. 
 RECITALS 
 Reference is made to that
certain Exclusive License Agreement dated December 18, 2007, between the parties to this Amendment (the “Agreement”). 
 The
Parties desire to amend the Agreement as set forth herein. 
 Now, therefore, in consideration of the mutual promises set forth herein and
for other good and valuable consideration, the receipt and sufficiency of which is acknowledged by the Parties hereto, the Parties hereto agree as follows: 
 1.  AMENDMENTS 
 1.1 Amendment and Restatement of Section 1.10. Section 1.10 of the
Agreement is hereby deleted and replaced in its entirety with the following language: 
 “1.10 “Licensed Field” shall mean
[***]. 
 1.2 Addition of Section 4.4.4. The following language shall be added to the Agreement as Section
4.4.4: 
 “4.4.4 Limitation on the Number of Shares Issued. Notwithstanding anything to the contrary in this Agreement, in no
event shall the aggregate number of Shares issued pursuant to this Agreement be greater than 19.9% of the number of shares of Common Stock outstanding on the Effective Date. In the event that an issuance of Shares pursuant to this Agreement would
cause an aggregate issuance of Shares that is more than 19.9% of the number of shares Common Stock outstanding on the Effective Date, the Licensee shall make a cash payment to the Licensor equal to the difference between cash value of the Shares
that were scheduled to be issued pursuant to this Agreement, and the value of the Shares that were actually issued after giving effect to the limitation set forth in this Section 4.4.4.” 
  
 [***] – Confidential Treatment Requested 

 2.  MISCELLANEOUS 
 In the event of any conflict between the provisions of this Amendment and the Agreement, the provisions of this Amendment shall prevail. Other than as set
forth in this Amendment, the remainder of the Agreement shall remain in full force and effect. 
 [Signature Page Follows] 
 [***] – Confidential Treatment Requested 
  

 IN WITNESS WHEREOF, the Parties and Holdings have caused this Amendment to be executed by their duly authorized
representative. 
  

									
	ALPHATEC SPINE, INC.	 		 	PROGRESSIVE SPINAL
		 		 	TECHNOLOGIES LLC:
					
	By:	 	/s/ Dirk Kuyper	 		 	By:	 	E. Skott Greenlagh
		 	Name: Dirk Kuyper	 		 		 	Name: E. Skott Greenlagh
		 	Title:   President and CEO	 		 		 	Title:   CEO
			
	ALPHATEC HOLDINGS, INC.	 		 	
					
	By:	 	/s/ Dirk Kuyper	 		 		 	
		 	Name: Dirk Kuyper	 		 		 	
		 	Title:   President and CEO	 		 		 	

  
 [***] – Confidential
Treatment RequestedSecond Amendment to Exclusive License Agreement

 Exhibit 10.23 
 SECOND AMENDMENT TO 
 EXCLUSIVE LICENSE AGREEMENT 
 This Second Amendment to the License and Supply Agreement (this “Amendment”) is made as of January 12, 2009 by and among Alphatec Spine,
Inc., a Delaware corporation with a principal place of business at 5818 El Camino Real, Carlsbad, California 92008 (“Licensee”), Progressive Spinal Technologies LLC, a limited liability company organized under the laws of the state of
Delaware, with an address at 410 East Walnut Street, Suite #8, Perkasie, Pennsylvania 18944 (“Licensor”) and Alphatec Holdings, Inc., a Delaware corporation with a principal place of business at 5818 El Camino Real, Carlsbad, California
92008 (“Holdings”). Capitalized terms undefined herein shall have the meaning ascribed them in the Agreement. 
 RECITALS 

 Reference is made to that certain Exclusive License Agreement dated December 18, 2007, as amended, between the parties to this
Amendment (the “Agreement”). 
 The Parties desire to amend the Agreement as set forth herein. 
 Now, therefore, in consideration of the mutual promises set forth herein and for other good and valuable consideration, the receipt and sufficiency of
which is acknowledged by the Parties hereto, the Parties hereto agree as follows: 
  

	1.	AMENDMENTS 

 1.1 Amendment and Restatement of
Section 4.1.2. Section 4.1.2 of the Agreement is hereby deleted and replaced in its entirety with the following language: 
 “4.1.2 Milestone Payments. Licensee shall pay milestone payments (or in the case of the Common Stock cause the issuance thereof by Holdings) to Licensor (each such payment or issuance a “Milestone Payment”) as
specified below no more than thirty (30) days after the occurrence of the corresponding event designated below, unless this Agreement has been terminated prior to such due date; provided that Licensor hereby assigns to its affiliate [***] and
(ii) the right to enforce this Agreement to the extent necessary [***], and Licensee and Holdings hereby consents to both such assignments. No Milestone Payments described in this Subsection 4.1.2 shall be credited against or otherwise reduce
any other amounts payable hereunder. 
 CONFIDENTIAL TREATMENT REQUESTED 

			
	 Event
	 	 Milestone Payment

		
	[***]	 	[***]
		
	[***]	 	[***]
		
	[***]	 	[***]
		
	[***]	 	[***]
		
	[***]	 	[***]

  

	2.	MISCELLANEOUS 

 In the event of any conflict between
the provisions of this Amendment and the Agreement, the provisions of this Amendment shall prevail. Other than as set forth in this Amendment, the remainder of the Agreement shall remain in full force and effect. 
 [Signatures Follow] 
 IN WITNESS WHEREOF, the Parties and
Holdings have caused this Amendment to be executed by their duly authorized representative. 
  

									
	ALPHATEC SPINE, INC.	 		 	 PROGRESSIVE SPINAL
 TECHNOLOGIES
LLC:

					
	By:	 	/s/ Dirk Kuyper	 		 	By:	 	/s/ E. Skott Greenlagh
		 	Name: Dirk Kuyper	 		 		 	Name: E. Skott Greenlagh
		 	Title: President and CEO	 		 		 	Title: CEO

  

			
	ALPHATEC HOLDINGS, INC.
		
	By:	 	/s/ Dirk Kuyper
		 	Name: Dirk Kuyper
		 	Title: President and CEO

 CONFIDENTIAL TREATMENT REQUESTEDLoan and Security Agreement

 Exhibit 10.26 
 LOAN AND SECURITY AGREEMENT 
 THIS LOAN AND SECURITY AGREEMENT (this
“Agreement”) dated as of December 5, 2008 (the “Effective Date”) between SILICON VALLEY BANK (“Bank”), as collateral agent (the “Collateral Agent”), Bank, as a lender,
and OXFORD FINANCE CORPORATION (“Oxford”; each, of Bank and Oxford are sometimes individually referred to as a “Lender” and collectively, as the “Lenders”), and ALPHATEC SPINE, INC., a
California corporation (“Alphatec”) and ALPHATEC HOLDINGS, INC., a Delaware corporation (“Parent” and together with Alphatec, each a “Borrower” and collectively,
“Borrowers”), provides the terms on which Lenders shall lend to Borrowers and Borrowers shall repay Lenders. The parties agree as follows: 
  

	 	1	ACCOUNTING AND OTHER TERMS 

 Accounting terms
not defined in this Agreement shall be construed following GAAP. Calculations and determinations must be made following GAAP. Capitalized terms not otherwise defined in this Agreement shall have the meanings set forth in Section 13. All
other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the Code to the extent such terms are defined therein. 
  

	 	2	LOAN AND TERMS OF PAYMENT 

 2.1 Promise to
Pay. Borrowers hereby unconditionally promise to pay Lenders the outstanding principal amount of all Credit Extensions and accrued and unpaid interest thereon and any other amounts due hereunder as and when due in accordance with this Agreement.

 2.1.1 Growth Capital Loan Facility. 
 (a) Availability. Subject to the terms and conditions of this Agreement, Lenders agree, severally and not jointly, to lend to Borrowers, on the Effective Date or as soon thereafter as is practical, an advance
(the “Growth Capital Advance”), according to each Lender’s pro rata share of the Growth Capital Loan Commitment (based upon the respective Growth Capital Commitment Percentage of each Lender). When repaid, the Growth Capital
Advance may not be re-borrowed. 
 (b) Repayment. Borrowers shall make monthly payments of interest only on the Growth
Capital Advance, in arrears commencing on January 1, 2009 and continuing thereafter on the first day of each successive calendar month during the Growth Capital Interest Only Period. Commencing on the Growth Capital Amortization Date, Borrowers
shall make thirty (30) consecutive equal monthly payments of principal and interest in arrears, which would fully amortize the outstanding Growth Capital Advance as of the Growth Capital Amortization Date over the Growth Capital Repayment
Period and continuing thereafter during the Growth Capital Repayment Period on the first day of each successive calendar month. All unpaid principal and accrued and unpaid interest is due and payable in full on the Growth Capital Maturity Date with
respect to the Growth Capital Advance. The Growth Capital Advance may only be prepaid in accordance with Sections 2.1.1(c) or 2.1.1(d). 
 (c) Prepayment. Borrowers shall have the option to prepay all, but not less than all, of the Growth Capital Advance advanced by Lenders under this Agreement, provided, (a) Alphatec provides
written notice to Lenders of Borrowers’ election to prepay the Growth Capital Advance at least five (5) Business Days prior to such prepayment, and (b) Borrowers pay, on the date of the prepayment (i) all outstanding
principal and accrued interest on the Growth Capital Advance; (ii) the Prepayment Fee (subject to Section 2.5(e)) and the Growth Capital Final Payment; and (iii) all other sums, including Lenders’ Expenses, if any, that have
become due and payable hereunder with respect to the Growth Capital Advance. 
 (d) Mandatory Prepayment Upon an
Acceleration. If the Growth Capital Advance is accelerated following the occurrence of an Event of Default, Borrowers shall immediately pay to Lenders an amount equal to the sum of: (i) all outstanding principal plus accrued and unpaid
interest on the Growth Capital Advance, (ii) the Prepayment Fee and the Growth Capital Final Payment, plus (iii) all other sums, if any, that shall have become due and payable, including interest at the Default Rate with respect to any
past due amounts. 

 2.1.2 Revolving Advances. 
 (a) Availability. Subject to the terms and conditions of this Agreement and to deduction of Reserves, Lenders agree, severally and
not jointly, to lend to Borrowers from time to time prior to the Revolving Line Maturity Date, according to each Lender’s pro rata share of the Revolving Line (based upon the respective Revolving Commitment Percentage of each Lender), Revolving
Advances not exceeding the Availability Amount. Amounts borrowed hereunder may be repaid and, prior to the Revolving Line Maturity Date, reborrowed, subject to the applicable terms and conditions precedent herein. 
 (b) Termination; Repayment. The Revolving Line terminates on the Revolving Line Maturity Date, when the principal amount of all
Revolving Advances, the unpaid interest thereon, and all other Obligations relating to the Revolving Line (including but not limited to the Revolving Line Termination Fee) shall be immediately due and payable. 
 2.1.3 Letters of Credit Sublimit. 
 (a) Letters of Credit. As part of the Revolving Line, Bank shall issue or have issued Letters of Credit for Borrowers’ account. Such aggregate amounts utilized hereunder shall at all times reduce the
amount otherwise available for Revolving Advances under the Revolving Line. The face amount of outstanding Letters of Credit (including drawn but unreimbursed Letters of Credit and any Letter of Credit Reserve) may not exceed One Million Dollars
($1,000,000), inclusive of Credit Extensions relating to Sections 2.1.4 and 2.1.5. The aggregate amount available to be used for the issuance of Letters of Credit may not exceed (i) the lesser of (A) the Revolving Line or (B) the
Borrowing Base, minus (ii) the outstanding principal amount of any Revolving Advances (including any amounts used for Cash Management Services and the face amount of any outstanding Letters of Credit (including drawn but unreimbursed Letters of
Credit and any Letter of Credit Reserve) and minus (iii) the FX Reduction Amount. If, on the Revolving Line Maturity Date, there are any outstanding Letters of Credit, then on such date Borrowers shall provide to Agent cash collateral in an
amount equal to one hundred five percent (105%) of the face amount of all such Letters of Credit plus all interest, fees, and costs due or to become due in connection therewith (as estimated by Bank in its good faith business judgment), to
secure all of the Obligations relating to said Letters of Credit. All Letters of Credit shall be in form and substance acceptable to Bank in its sole discretion and shall be subject to the terms and conditions of Bank’s standard Application and
Letter of Credit Agreement (the “Letter of Credit Application”). Borrowers agree to execute any further documentation in connection with the Letters of Credit as Bank may reasonably request. Borrowers further agree to be bound by
the regulations and interpretations of the issuer of any Letters of Credit guarantied by Bank and opened for Borrowers’ account or by Bank’s interpretations of any Letter of Credit issued by Bank for Borrowers’ account, and Borrowers
understand and agree that Bank shall not be liable for any error, negligence, or mistake, made in good faith whether of omission or commission, in following Borrowers’ instructions or those contained in the Letters of Credit or any
modifications, amendments, or supplements thereto. 
 (b) Letter of Credit Participations. Bank irrevocably agrees to
grant and hereby grants to each Lender, and, to induce the Bank to issue Letters of Credit, each Lender irrevocably agrees to accept and purchase and hereby accepts and purchases from Bank, on the terms and conditions set forth below, for such
Lender’s own account and risk an undivided interest equal to such Lender’s Revolving Commitment Percentage in Bank’s obligations and rights under and in respect of each Letter of Credit and the amount of each draft paid by Bank
thereunder. Each Lender agrees with Bank that, if a draft is paid under any Letter of Credit for which Bank is not reimbursed in full by Borrowers pursuant to Section 2.1.3(c), such Lender shall pay to Bank upon demand at Bank’s address
for notices specified herein an amount equal to such Lender’s Revolving Commitment Percentage of the amount of such draft, or any part thereof, that is not so reimbursed. Each Lender’s obligation to pay such amount shall be absolute and
unconditional and shall not be affected by any circumstance, including (i) any setoff, counterclaim, recoupment, defense or other right that such Lender may have against Bank, Borrowers or any other Person for any reason whatsoever,
(ii) the occurrence or continuance of a Default or an Event of Default or the failure to satisfy any of the other conditions specified in Sections 3.1 or 3.2, (iii) any adverse change in the condition (financial or otherwise) of Borrowers,
(iv) any breach of this Agreement or any other Loan Document by Borrowers or any other Lender or (v) any other circumstance, happening or event whatsoever, whether or not similar to any of the foregoing. 

 (c) Reimbursement. 
 (i) If Bank shall make any disbursement in respect of a Letter of Credit, Borrowers shall pay or cause to be paid to Bank an amount
equal to the entire amount of such disbursement not later than the immediately following Business Day. Each such payment shall be made to Bank at its address for notices referred to herein in Dollars and in immediately available funds. 

(ii) If Bank shall not have received from Borrowers the payment that it is required to make pursuant to Section 2.1.3(c)(i)
with respect to a Letter of Credit within the time specified in such Section, Bank will promptly notify the Collateral Agent of the disbursement and the Collateral Agent will promptly notify each Lender of such disbursement and its Revolving
Commitment Percentage thereof, and each Lender shall pay to Bank upon demand at Bank’s address for notices specified herein an amount equal to such Lender’s Revolving Commitment Percentage of such disbursement; upon such payment pursuant
to this paragraph to reimburse Bank for any disbursement, Borrowers shall be required to reimburse the Lenders for such payments (including interest accrued thereon from the date of such payment until the date of such reimbursement at the rate
applicable to Revolving Advances under the Revolving Line) on demand and the Lenders shall be deemed to have extended, and Borrowers shall be deemed to have accepted, a Revolving Advance under the Revolving Line in the aggregate principal amount of
such payment without further action on the part of any party, and the Letter of Credit sublimit shall be reduced by such amount; any amount so paid pursuant to this paragraph shall, on and after the payment date thereof, be deemed to be Revolving
Advances under the Revolving Line for all purposes hereunder. 
 (d) Letter of Credit Payments. If any draft shall be
presented for payment under any Letter of Credit, Bank shall promptly notify Borrowers and the Collateral Agent of the date and amount thereof. The responsibility of Bank to Borrowers in connection with any draft presented for payment under any
Letter of Credit shall, in addition to any payment obligation expressly provided for in such Letter of Credit, be limited to determining that the documents (including each draft) delivered under such Letter of Credit in connection with such
presentment are substantially in conformity with such Letter of Credit. If Bank shall make any disbursement in respect of a Letter of Credit, unless either (i) Borrowers reimburse such disbursement in full within the time period specified in
Section 2.1.3(c) or (ii) the Lenders shall reimburse such disbursement in full on such date as provided in Section 2.1.3(c) then, the unpaid amount thereof shall bear interest for the account of Bank, for each day from and including
the date of such disbursement up to but excluding, the earlier of, the date of payment by Borrowers, at the rate per annum that would apply to such amount if such amount were a Revolving Advance under the Revolving Line; provided that the provisions
of Section 2.1.3(c)(ii) shall be applicable to any such amounts not paid when due. 
 (e) Obligations Absolute.
Borrowers’ obligations under this Section 2.1.3 shall be absolute and unconditional under any and all circumstances and irrespective of any setoff, counterclaim or defense to payment that Borrowers may have or have had against Bank, any
Lender, any beneficiary of a Letter of Credit or any other Person. Borrowers also agree with Bank that Bank, absent Bank’s gross negligence or willful misconduct, shall not be responsible for, and Borrowers’ obligations hereunder shall not
be affected by, among other things, the validity or genuineness of documents or of any endorsements thereon, even though such documents shall in fact prove to be invalid, fraudulent or forged, or any dispute between or among Borrowers and any
beneficiary of any Letter of Credit or any other party to which such Letter of Credit may be transferred or any claims whatsoever of Borrowers against any beneficiary of such Letter of Credit or any such transferee. Bank shall not be liable for any
error, omission, interruption or delay in transmission, dispatch or delivery of any message or advice, however transmitted, in connection with any Letter of Credit, except for errors or omissions found by a final and nonappealable decision of a
court of competent jurisdiction to have resulted from the gross negligence or willful misconduct of Bank. Borrowers agree that any action taken or omitted by Bank under or in connection with any Letter of Credit or the related drafts or documents,
if done in the absence of gross negligence or willful misconduct, shall be binding on Borrowers and shall not result in any liability of Bank to Borrowers. 
 In addition to amounts payable as elsewhere provided in the Agreement, Borrowers hereby agree to pay and to protect, indemnify, and save Bank harmless from and against any and all claims, demands, liabilities,
damages, losses, costs, charges and expenses (including reasonable attorneys’ fees) that Bank may incur or be subject to as a consequence, direct or indirect, of (A) the issuance of any Letter of Credit, or (B) the failure of Bank or
of any Lender to honor a demand for payment under any Letter of Credit thereof as a result of any act or omission, whether rightful or wrongful, of any present or future de jure or de facto government or Governmental Authority, in each case other
than to the extent solely as a result of the gross negligence or willful misconduct of Bank or such Lender (as finally determined by a court of competent jurisdiction). 

 (f) Borrowers may request that Bank issue a Letter of Credit payable in a Foreign
Currency. If a demand for payment is made under any such Letter of Credit, Bank shall treat such demand as a Revolving Advance to Borrowers of the equivalent of the amount thereof (plus fees and charges in connection therewith such as wire, cable,
SWIFT or similar charges) in Dollars at the then-prevailing rate of exchange in San Francisco, California, for sales of the Foreign Currency for transfer to the country issuing such Foreign Currency. 
 (g) To guard against fluctuations in currency exchange rates, upon the issuance of any Letter of Credit payable in a Foreign Currency,
Bank shall create a reserve (the “Letter of Credit Reserve”) under the Revolving Line in an amount equal to ten percent (10%) of the face amount of such Letter of Credit. The amount of the Letter of Credit Reserve may be
adjusted by Bank from time to time to account for fluctuations in the exchange rate. The availability of funds under the Revolving Line shall be reduced by the amount of such Letter of Credit Reserve for as long as such Letter of Credit remains
outstanding. 
 2.1.4 Foreign Exchange Sublimit. As part of the Revolving Line, Borrowers may enter into foreign exchange
contracts with Lenders under which Borrowers commit to purchase from or sell to Lenders (in accordance with their Revolving Commitment Percentages) a specific amount of Foreign Currency (each, a “FX Forward Contract”) on a specified
date (the “Settlement Date”). FX Forward Contracts shall have a Settlement Date of at least one (1) FX Business Day after the contract date and shall be subject to a reserve of ten percent (10%) of each outstanding FX
Forward Contract in a maximum aggregate amount equal to Two Hundred Fifty Thousand Dollars ($250,000) (such maximum shall be the “FX Reserve”). The aggregate amount of FX Forward Contracts at any one time may not exceed ten
(10) times the amount of the FX Reserve. The amount otherwise available for Credit Extensions under the Revolving Line shall be reduced by an amount equal to ten percent (10%) of each outstanding FX Forward Contract (the “FX
Reduction Amount”). Any amounts that are not paid by Borrowers for any FX Forward Contracts will be treated as Revolving Advances under the Revolving Line under the Revolving Facility and will accrue interest at the interest rate
applicable to Revolving Advances. 
 2.1.5 Cash Management Services Sublimit. Borrowers may use up to One Hundred Thousand
Dollars ($100,000), inclusive of Credit Extensions relating to Sections 2.1.3 and 2.1.4 of the Revolving Line for Bank’s cash management services which may include merchant services, direct deposit of payroll, business credit card, and check
cashing services identified in Bank’s various cash management services agreements (collectively, the “Cash Management Services”). 
 2.2 Overadvances. If, at any time, the sum of (a) the outstanding principal amount of any Revolving Advances (including any amounts used for Cash Management Services), plus (b) the face amount
of any outstanding Letters of Credit (including drawn but unreimbursed Letters of Credit and any Letter of Credit Reserve), plus (c) the FX Reduction Amount, exceeds the lesser of either the Revolving Line or the Borrowing Base (such amount
being an “Overadvance”), Borrowers shall immediately pay to Lenders in cash the ratable amount (according to each such Lender’s Revolving Commitment Percentage) of such Overadvance. Without limiting Borrowers’ obligation
to repay Lenders any amount of the Overadvance, Borrowers agree to pay Lenders interest on the outstanding amount of any Overadvance, on demand, at the Default Rate. 
 2.3 Lockbox; Account Collection Services. 
 (a) Within thirty (30) days of the Effective Date, Borrowers shall direct each Account Debtor (and each depository institution where proceeds of Accounts are on deposit) to remit payments with respect to the
Accounts to a lockbox account established with Bank or to wire transfer payments to a cash collateral account that Bank controls (collectively, the “Lockbox”). It will be considered an immediate Event of Default if the Lockbox is
not set-up and operational as of the date set forth in the preceding sentence. 
 (b) Until such Lockbox is established, the
proceeds of the Accounts shall be paid by the Account Debtors to an address consented to by the Lender. Upon receipt by a Borrower of such proceeds, such Borrower shall immediately transfer and deliver same to Bank, for the ratable benefit of the
Lenders, along with a detailed cash receipts journal. Provided no Event of Default exists or an event that with notice or lapse of time will be an Event of Default, within three (3) Business Days of receipt 

 
of such amounts by Bank, Bank will turn over to Borrowers the proceeds of the Accounts, less any amounts due to Lenders, such as payments due to the Lender,
other fees and expenses, or otherwise. This Section does not impose any affirmative duty on any Lender to perform any act other than as specifically set forth herein. All Accounts and the proceeds thereof are Collateral and if an Event of Default
occurs, Bank may apply the proceeds of such Accounts to the Obligations. Without limiting the foregoing, the Lockbox (and the amounts in the Lockbox) shall be subject to a “lock box control” agreement which will provide for, among other
things the establishment of “control” within the meaning of Article 9 of the UCC. Unless an Event of Default has occurred and is continuing, the Borrowers shall have immediate and full access to any funds held in the Lockbox account and
such funds shall not be subject to any conditions or restrictions whatsoever other than those of the Bank and as provided in this Agreement and related documents; provided, however, that nothing herein shall (i) affect or reduce Borrowers’
obligations to pay in full all amounts due to Lenders under this Agreement, or (ii) in any manner limit the recourse of Lenders to the Collateral to satisfy the Borrowers’ Obligations. 
 2.4 Payment of Interest on the Credit Extensions. 
 (a) Interest Rates. 
 (i) Growth Capital Advance. Subject to
Section 2.4(b), the principal amount outstanding for the Growth Capital Advance shall accrue interest, which interest shall be payable monthly in arrears, at a fixed per annum rate equal to the lesser of (A) the greater of
(x) eleven and one quarter percent (11.25%) or (y) 800 basis points (8.00%) above the 3-month LIBOR as of the date that the Notes for the Growth Capital Advance are prepared or (B) fourteen and one half percent (14.50%).

 (ii) Revolving Advances. Subject to Section 2.4(b), the principal amount outstanding under the
Revolving Line shall accrue interest at a per annum rate equal to the greater of (A) (x) when Borrowers’ Net Income, for one (1) of any of the two (2) consecutive quarters preceding the date of payment is less than Seven
Hundred Fifty Thousand Dollars ($750,000), two and one half percent (2.50%) above the Prime Rate; and (y) when Borrowers’ Net Income, for the two (2) consecutive quarters preceding the date of payment is greater than Seven
Hundred Fifty Thousand Dollars ($750,000) per quarter, two percent (2.00%) above the Prime Rate or (B) six and one half percent (6.50%); in each case, which interest shall be payable monthly. 
 (b) Default Rate. Immediately upon the occurrence and during the continuance of an Event of Default, Obligations shall bear
interest at a rate per annum which is five percentage points above the rate effective immediately before the Event of Default (but in no event in excess of the maximum rate permitted by then applicable law) (the “Default Rate”).
Payment or acceptance of the increased interest rate provided in this Section 2.4(b) is not a permitted alternative to timely payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or
remedies of Lenders. 
 (c) Adjustment to Interest Rate. Changes to the interest rate of any Credit Extension (accruing
interest at the Prime Rate) based on changes to the Prime Rate shall be effective on the effective date of any change to the Prime Rate and to the extent of any such change. 
 (d) 360-Day Year. Interest shall be computed on the basis of a 360-day year of twelve 30-day months. 
 (e) Debit of Accounts. Collateral Agent, for the benefit of the Lenders, may debit any of Borrowers’ deposit accounts,
including the Designated Deposit Account, for principal and interest payments or any other amounts Borrowers owe Lenders when due. These debits shall not constitute a set-off. 
 (f) Payments; Interest Computation; Float Charge. Unless otherwise provided, interest is payable monthly on the first calendar day
of each month. In computing interest on the Obligations, all Payments received after 1:00 p.m. Pacific time on any day shall be deemed received on the next Business Day. Lenders shall not, however, be required to credit Borrowers’ account for
the amount of any item of payment which is unsatisfactory to any Lender in its good faith business judgment, and Lenders may charge Borrowers’ Designated Deposit Account for the amount of any item of payment which is returned to any Lender
unpaid. 

 2.5 Fees. Borrowers shall pay to Collateral Agent: 
 (a) Growth Capital Loan Fee. A fully earned, non-refundable loan fee on account of the Growth Capital Loan Commitment of One
Hundred Fifty Thousand Dollars ($150,000), to be shared among the Lenders pro rata according to the Growth Capital Commitment Percentage of each Lender; receipt of One Hundred Thousand Dollars ($100,000) of which hereby is acknowledged, with the
balance due and payable on the Effective Date; 
 (b) Revolving Commitment Fee. A fully earned, non-refundable
commitment fee on account of the Revolving Line in the amount of One Hundred Fifty Thousand Dollars ($150,000) on the Effective Date, to be shared among the Lenders pro rata according to their Revolving Commitment Percentages of the Revolving Line;

 (c) Unused Revolving Line Facility Fee. A fee (the “Unused Revolving Line Facility Fee”), payable
monthly, in arrears, on a calendar year basis, in an amount equal to one half of one percent (0.50%) per annum of the average unused portion of the Revolving Line, as determined by Collateral Agent, for the ratable benefit of the Lenders according
to their Revolving Commitment Percentages. The unused portion of the Revolving Line, for the purposes of this calculation, shall include amounts reserved under the Cash Management Services Sublimit for products provided and under the Foreign
Exchange Sublimit for FX Forward Contracts. Borrowers shall not be entitled to any credit, rebate or repayment of any Unused Revolving Line Facility Fee previously earned by any Lender pursuant to this Section notwithstanding any termination of the
Agreement, or suspension or termination of Lenders’ obligation to make loans and advances hereunder; 
 (d) Revolving
Line Termination Fee. The Revolving Line Termination Fee, if and when due hereunder. 
 (e) Prepayment Fee. The
Prepayment Fee, if and when due hereunder; provided however, if as of the date the Prepayment Fee would otherwise be due and payable, a prepayment is made by Borrowers in connection with an Acquisition and the per share consideration that would be
received by the Lenders upon the sale or exchange of the Shares (as defined in the Warrants) issuable to the Lenders upon exercise of the Warrants in connection with such Acquisition is at least one hundred fifty percent (150%) of the Warrant
Price (as defined in the Warrants), then the Prepayment Fee shall be waived by the Lenders; 
 (f) Growth Capital Final
Payment. The Growth Capital Final Payment, when due hereunder; and 
 (g) Lenders’ Expenses. All Lenders’
Expenses (including reasonable attorneys’ fees and reasonable expenses incurred in connection with the documentation and negotiation of this Agreement) incurred through and after the Effective Date, when due. 
  

	 	3	CONDITIONS OF LOANS 

 3.1 Conditions
Precedent to Initial Credit Extension. Lenders’ obligation to make the initial Credit Extension is subject to the condition precedent that Lenders shall have received, in form and substance satisfactory to Lenders, such documents, and
completion of such other matters, as Lenders may reasonably deem necessary or appropriate, including, without limitation: 
 (a) duly executed original signatures to the Loan Documents; 
 (b) a duly executed original signature to the Warrant
to be issued to Oxford and a duly executed original signature to the Warrant to be issued to Bank; 
 (c) duly executed
original signatures to the Control Agreements, if any; 

 (d) their Operating Documents and a good standing certificate of each Borrower and of
Guarantor certified by the Secretary of State of the States of Delaware (with respect to Parent) and California (with respect to Borrowers and Guarantor) as of a date no earlier than thirty (30) days prior to the Effective Date; 
 (e) duly executed original signatures to the completed Borrowing Resolutions for each Borrower, Guarantor, Milverton and API (one set for
each Lender); 
 (f) the certificate(s) for the Shares, together with stock powers, duly executed in blank by the applicable
Borrower; 
 (g) duly executed copies of the Milverton Organizational Documents and the API Organizational Documents;

 (h) certified copies, dated as of a recent date, of financing statement searches, as Lenders shall request, accompanied by
written evidence (including any UCC termination statements) that the Liens indicated in any such financing statements either constitute Permitted Liens or have been or, in connection with the initial Credit Extension, will be terminated or released;

 (i) landlord’s consents for each of Borrowers’ leased properties executed in favor of Collateral Agent, for the
ratable benefit of the Lenders, provided, however, that no landlord consent shall be required for Borrowers’ leased properties located at 6350 Yarrow Drive, Carlsbad, CA 92011 and 6078 Corte Del Cedro, Ste. B, Carlsbad, CA 92011 so long as
Borrowers have vacated such properties no later than April 1, 2009; 
 (j) a legal opinion of Borrowers’ and
Guarantor’s counsel dated as of the Effective Date together with the duly executed original signatures thereto; 
 (k)
two Perfection Certificate(s) executed by Parent (one for each Lender); 
 (l) a duly executed copy of the Payoff Letter;

 (m) evidence satisfactory to Lenders that the insurance policies required by Section 6.7 hereof are in full
force and effect, together with appropriate evidence showing loss payable and/or additional insured clauses or endorsements in favor of each Lender; and 
 (n) payment of the fees and Lenders’ Expenses then due as specified in Section 2.5 hereof. 
 3.2 Conditions Precedent to all Credit Extensions. Lenders’ obligations to make each Credit Extension, including the initial Credit Extension, are subject to the following: 
 (a) Alphatec shall have duly executed and delivered to Lenders a Payment/Advance Form, together with an executed Transaction Report;

 (b) Borrowers shall have duly executed and delivered to each Lender a Note in the amount of such Lender’s Growth
Capital Advance; 
 (c) the representations and warranties in Section 5 shall be true in all material respects on
the date of the Payment/Advance Form and the Transaction Report and on the Funding Date of each Credit Extension; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are
qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date, and no
Default or Event of Default shall have occurred and be continuing or result from the Credit Extension. Each Credit Extension is each Borrower’s representation and warranty on that date that the representations and warranties in
Section 5 remain true in all material respects; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof;
and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date; 

 (d) receipt of and approval by Lenders of two updated Perfection Certificate(s) executed
by Parent (one for each Lender), which shall include any additional information that shall be necessary to make such Perfection Certificates complete and correct in all material respects as of the date of such Credit Extension; provided that such
approval will not be unreasonably withheld due to immaterial changes from the prior Perfection Certificate(s) provided to Lenders; and 
 (e) in Lenders’ reasonable discretion, there has not been a Material Adverse Change. 
 3.3 Covenant
to Deliver. 
 Each Borrower agrees to deliver to Lenders each item required to be delivered to any Lender under this Agreement as a
condition to any Credit Extension. Each Borrower expressly agrees that the extension of a Credit Extension prior to the receipt by Lenders of any such item shall not constitute a waiver by Lenders of such Borrower’s obligation to deliver such
item, and any such extension in the absence of a required item shall be in Lenders’ sole discretion. 
 3.4 Procedures for Borrowing.

 (a) Growth Capital Advance. To obtain the Growth Capital Advance, Alphatec must deliver to Collateral Agent a
completed Payment/Advance Form in the form attached as Exhibit B. Upon receipt of the Payment/Advance Form, Collateral Agent shall promptly provide a copy of the same to each Lender. On the Growth Capital Funding Date, each Lender shall
credit and/or transfer (as applicable) to the Designated Deposit Account, an amount equal to its Growth Capital Commitment Percentage multiplied by the amount of the Growth Capital Advance, less any amounts owing from Borrowers to GE as of the
Growth Capital Funding Date, such amounts to be sent by Lenders via wire transfer directly to GE in accordance with the terms of the Payoff Letter. Each Lender may rely on any telephone notice given by a person whom such Lender reasonably believes
is a Responsible Officer. Borrowers shall indemnify each Lender for any loss Lender suffers due to such reliance. 
 (b)
Revolving Advances. Subject to the prior satisfaction of all other applicable conditions to the making of a Revolving Advance set forth in this Agreement, to obtain a Revolving Advance, Alphatec shall notify Collateral Agent by electronic
mail, facsimile, or telephone by 12:00 p.m. Pacific time on the Funding Date of the Revolving Advance. Together with such notification, Alphatec must promptly deliver to Collateral Agent by electronic mail or facsimile a completed Transaction Report
executed by a Responsible Officer or his or her designee. Collateral Agent, on behalf of Lenders, shall credit Revolving Advances to the Designated Deposit Account, and such Revolving Advances shall be deemed to be Revolving Advances by each of the
Lenders in the amount of their respective Revolving Commitment Percentages. The Lenders shall reimburse Collateral Agent for Revolving Advances made by Collateral Agent. (The Lenders and Collateral Agent, as among themselves, agree that such
reimbursement shall occur by the second Business Day of each week; the Borrower is not a party to or beneficiary of this agreement and it may be amended without the Borrower’s consent.) Lenders may make Revolving Advances under this Agreement
based on instructions from a Responsible Officer or his or her designee or without instructions if the Revolving Advances are necessary to meet Obligations which have become due. Each Lender may rely on any telephone notice given by a person whom
such Lender reasonably believes is a Responsible Officer or designee. Borrowers shall indemnify each Lender for any loss Lender suffers due to such reliance. 
  

	 	4	CREATION OF SECURITY INTEREST 

 4.1 Grant
of Security Interest. Each Borrower hereby grants to the Collateral Agent, for the benefit of Lenders, to secure the payment and performance in full of all of the Obligations, a continuing security interest in, and pledges to the Collateral
Agent, for the benefit of Lenders, the Collateral, wherever located, whether now owned or hereafter acquired or arising, and all proceeds and products thereof. Each Borrower represents, warrants, and covenants that the security interest granted
herein is and shall at all times continue to be a first priority perfected security interest in the Collateral (subject only to Permitted Liens that may have superior 

 
priority under this Agreement). If a Borrower shall acquire a commercial tort claim (as defined in the Code), such Borrower shall promptly notify Collateral
Agent in a writing signed by such Borrower of the general details thereof (and further details as may be required by Collateral Agent) and grant to Collateral Agent, for the benefit of Lenders, in such writing a security interest therein and in the
proceeds thereof, all upon the terms of this Agreement, with such writing to be in form and substance reasonably satisfactory to Collateral Agent. 
 If this Agreement is terminated, Collateral Agent’s Lien in the Collateral shall continue until the Obligations (other than inchoate indemnity obligations) are repaid in full in cash. Upon payment in full in cash of the Obligations and
at such time as the Lenders’ obligation to make Credit Extensions has terminated, Collateral Agent shall, at Borrowers’ sole cost and expense, promptly release its Liens in the Collateral and all rights therein shall revert to Borrowers.

 4.2 Authorization to File Financing Statements. Each Borrower hereby authorizes Collateral Agent to file financing statements,
without notice to either Borrower, with all appropriate jurisdictions to perfect or protect Collateral Agents and/or Lenders’ interest or rights hereunder, including a notice that any disposition of the Collateral, by either a Borrower or any
other Person, shall be deemed to violate the rights of Collateral Agent and Lenders under the Code. 
 4.3 Pledge of
Collateral. Each Borrower hereby pledges, assigns and grants to the Collateral Agent, for the ratable benefit of Lenders, a security interest in all the Shares, together with all proceeds and substitutions thereof, all cash, stock and
other moneys and property paid thereon, all rights to subscribe for securities declared or granted in connection therewith, and all other cash and noncash proceeds of the foregoing, as security for the performance of the Obligations. On the
Effective Date, the certificate or certificates for the Shares will be delivered to the Collateral Agent, accompanied by an instrument of assignment duly executed in blank by the applicable Borrower. To the extent required by the terms and
conditions governing the Shares, the applicable Borrower shall cause the books of each entity whose Shares are part of the Collateral and any transfer agent to reflect the pledge of the Shares. Upon the occurrence of an Event of Default hereunder,
Collateral Agent may effect the transfer of any securities included in the Collateral (including but not limited to the Shares) into the name of the Lenders and cause new certificates representing such securities to be issued in the name of the
Lenders or their transferee. Each Borrower will execute and deliver such documents, and take or cause to be taken such actions, as the Collateral Agent or Lenders may reasonably request to perfect or continue the perfection of the Collateral
Agent’s security interest in the Shares. Unless an Event of Default shall have occurred and be continuing, Borrowers shall be entitled to exercise any voting rights with respect to the Shares and to give consents, waivers and ratifications in
respect thereof, provided that no vote shall be cast or consent, waiver or ratification given or action taken which would be inconsistent with any of the terms of this Agreement or which would constitute or create any violation of any of such terms.
All such rights to vote and give consents, waivers and ratifications shall terminate upon the occurrence and continuance of an Event of Default. 
  

	 	5	REPRESENTATIONS AND WARRANTIES 

 Each
Borrower represents and warrants as follows: 
 5.1 Due Organization and Authorization. Borrower and each of its Subsidiaries, if any,
are duly existing and in good standing, as Registered Organizations in their respective jurisdictions of formation and are qualified and licensed to do business and are in good standing in any jurisdiction in which the conduct of their business or
their ownership of property requires that they be qualified except where the failure to do so could not reasonably be expected to have a material adverse effect on Borrower’s business. In connection with this Agreement, Parent has delivered to
Collateral Agent a completed perfection certificate signed by Parent (as may be updated from time to time in accordance with Section 3.2(d), the “Perfection Certificate”). Borrower represents and warrants that
(a) Borrower’s exact legal name is that indicated on the Perfection Certificate and on the signature page hereof; (b) Borrower is an organization of the type and is organized in the jurisdiction set forth in the Perfection
Certificate; (c) the Perfection Certificate accurately sets forth Borrower’s organizational identification number or accurately states that Borrower has none; (d) the Perfection Certificate accurately sets forth Borrower’s place
of business, or, if more than one, its chief executive office as well as Borrower’s mailing address (if different than its chief executive office); (e) Borrower (and each of its predecessors) has not, in the past five (5) years,
changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its 

 
jurisdiction; and (f) all other information set forth on the Perfection Certificate pertaining to Borrower and each of its Subsidiaries is accurate and
complete. If Borrower is not now a Registered Organization but later becomes one, Borrower shall promptly notify Collateral Agent of such occurrence and provide Collateral Agent with Borrower’s organizational identification number. 

The execution, delivery and performance by Borrower of the Loan Documents to which it is a party (and with respect solely to Parent, the Warrants)
have been duly authorized, and do not (i) conflict with any of Borrower’s Operating Documents, (ii) contravene, conflict with, constitute a default under or violate any material Requirement of Law, (iii) contravene, conflict or
violate any applicable order, writ, judgment, injunction, decree, determination or award of any Governmental Authority by which Borrower or any of its Subsidiaries or any of their property or assets may be bound or affected, (iv) require any
action by, filing, registration, or qualification with, or Governmental Approval from, any Governmental Authority (except such Governmental Approvals which have already been obtained and are in full force and effect and except for filings with the
Securities Exchange Commission or NASDAQ, which shall be made following closing) or are being obtained pursuant to Section 6.1(b), or (v) constitute an event of default under any material agreement by which Borrower is bound. Borrower is
not in default under any agreement to which it is a party or by which it is bound in which the default could have a material adverse effect on Borrower’s business. 
 5.2 Collateral. Borrower has good title to, has rights in, and the power to transfer each item of the Collateral upon which it purports to grant a Lien hereunder, free and clear of any and all Liens except
Permitted Liens. Borrower has no deposit accounts other than the deposit accounts with Bank, the deposit accounts, if any, described in the Perfection Certificate delivered to Collateral Agent in connection herewith, or of which Borrower has given
Lenders notice and taken such actions as are necessary to give Collateral Agent a perfected security interest therein. 
 Other than with
respect to Consigned Collateral, none of the Collateral is in the possession of any third party bailee. None of the components of the Collateral (other than the Consigned Collateral) shall be maintained at locations other than as provided in the
Perfection Certificate or as Borrower has given Lenders notice pursuant to Section 7.2. In the event that Borrower, after the date hereof, intends to store or otherwise deliver any portion of the Collateral (other than the Consigned
Collateral) to a bailee, then Borrower will first receive the written consent of Lenders, such consent not to be unreasonably withheld, and such bailee must execute and deliver a bailee agreement in form and substance satisfactory to Collateral
Agent in its sole discretion. 
 For each Account with respect to which Revolving Advances are requested, on the date each Revolving Advance
is requested and made, such Account shall be an Eligible Account. 
 All statements made and all unpaid balances appearing in all invoices,
instruments and other documents evidencing the Eligible Accounts are and shall be true and correct and all such invoices, instruments and other documents, and all of each Borrower’s Books are genuine and in all respects what they purport to be.
Whether or not an Event of Default has occurred and is continuing, Bank may notify any Account Debtor owing a Borrower money of Bank’s security interest in such funds and verify the amount of such Eligible Account. All sales and other
transactions underlying or giving rise to each Eligible Account shall comply in all material respects with all applicable laws and governmental rules and regulations. No Borrower has any actual knowledge of any actual or imminent Insolvency
Proceeding of any Account Debtor whose accounts are Eligible Accounts in any Transaction Report. To the best of each Borrower’s knowledge, all signatures and endorsements on all documents, instruments, and agreements relating to all Eligible
Accounts are genuine, and all such documents, instruments and agreements are legally enforceable in accordance with their terms. 
 All
Inventory is in all material respects of good and marketable quality, free from material defects. For any item of Inventory consisting of Eligible Inventory in any Transaction Report, such Inventory (i) consists of finished goods, in good, new,
and salable condition, which is not perishable, returned, consigned, obsolete, not sellable, damaged, or defective, and is not comprised of demonstrative or custom inventory, works in progress, packaging or shipping materials, or supplies;
(ii) meets all applicable governmental standards; (iii) has been manufactured in compliance with the Fair Labor Standards Act; (iv) is not subject to any Liens, except the first priority Liens granted or in favor of Bank under this
Agreement or any of the other Loan Documents; and (v) is located at the locations identified by Borrower in the Perfection Certificate where it maintains Inventory (or any location permitted under Section 7.2). 

 Borrower is the sole owner of its intellectual property, except for non-exclusive licenses granted to its
customers in the ordinary course of business. Except as set forth in the Perfection Certificate, to the best of Borrower’s knowledge each patent is valid and enforceable, and no part of the intellectual property has been judged invalid or
unenforceable, in whole or in part, and to the best of Borrower’s knowledge, no claim has been made that any part of the intellectual property violates the rights of any third party except to the extent such claim could not reasonably be
expected to have a material adverse effect on Borrower’s business. Except as noted on the Perfection Certificate, Borrower is not a party to, nor is bound by, any material license or other agreement with respect to which Borrower is the
licensee (a) that prohibits or otherwise restricts Borrower from granting a security interest in Borrower’s interest in such license or agreement or any other property, or (b) for which a default under or termination of could
interfere with Collateral Agent’s right to sell any Collateral. Borrower shall provide written notice to Collateral Agent within ten (10) days of entering or becoming bound by any such license or agreement (other than over-the-counter
software that is commercially available to the public). Borrower shall take such steps as Collateral Agent reasonably requests to obtain the consent of, or waiver by, any person whose consent or waiver is necessary for (x) all such licenses or
agreements to be deemed “Collateral” and for Bank to have a security interest in it that might otherwise be restricted or prohibited by law or by the terms of any such license or agreement, whether now existing or entered into in the
future, and (y) Collateral Agent to have the ability in the event of a liquidation of any Collateral to dispose of such Collateral in accordance with Collateral Agent’s rights and remedies under this Agreement and the other Loan Documents.

 5.3 Litigation. Other than as set forth in the Perfection Certificate, there are no actions or proceedings pending or, to the
knowledge of the Responsible Officers, threatened in writing by or against Borrower or any of its Subsidiaries involving more than Five Hundred Thousand Dollars ($500,000). 
 5.4 No Material Deviation in Financial Statements. All consolidated financial statements for Borrower and any of its Subsidiaries delivered to
Lenders fairly present in all material respects Borrower’s consolidated financial condition and Borrower’s consolidated results of operations. There has not been any material deterioration in Borrower’s consolidated financial
condition since the date of the most recent financial statements submitted to Lenders. 
 5.5 Solvency. The fair salable value of
Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; Borrower is not left with unreasonably small capital after the transactions in this Agreement; and Borrower is able to pay its debts
(including trade debts) as they mature. 
 5.6 Regulatory Compliance. Borrower is not an “investment company” or a company
“controlled” by an “investment company” under the Investment Company Act of 1940, as amended. Borrower is not engaged as one of its important activities in extending credit for margin stock (under Regulations T and U of the
Federal Reserve Board of Governors). Borrower has complied in all material respects with the Federal Fair Labor Standards Act. Neither Borrower nor any of its Subsidiaries is a “holding company” or an “affiliate” of a
“holding company” or a “subsidiary company” of a “holding company” as each term is defined and used in the Public Utility Holding Company Act of 2005. Borrower has not violated any laws, ordinances or rules, the
violation of which could reasonably be expected to have a material adverse effect on its business. None of Borrower’s or any of its Subsidiaries’ properties or assets has been used by Borrower or any Subsidiary or, to the best of
Borrower’s knowledge, by previous Persons, in disposing, producing, storing, treating, or transporting any hazardous substance other than legally. Borrower and each of its Subsidiaries have (i) obtained all consents, approvals and
authorizations of, (ii) made all declarations or filings with, and (iii) given all notices to, all Government Authorities that, in the case of each of (i), (ii) and (iii) above, are necessary to continue their respective
businesses as currently conducted. 
 5.7 Subsidiaries; Investments. Borrower does not own any stock, partnership interest or other
equity securities except for Permitted Investments. 
 5.8 Tax Returns and Payments; Pension Contributions. Borrower has timely filed
all required tax returns and reports, and Borrower and its Subsidiaries have timely paid all foreign, federal, state and local taxes, assessments, deposits and contributions owed by Borrower. Borrower may defer payment of any contested taxes,
provided that Borrower (a) in good faith contests its obligation to 

 
pay the taxes by appropriate proceedings promptly and diligently instituted and conducted, (b) notifies Lenders in writing of the commencement of, and
any material development in, the proceedings, (c) posts bonds or takes any other steps required to prevent the governmental authority levying such contested taxes from obtaining a Lien upon any of the Collateral that is other than a
“Permitted Lien”. Borrower is unaware of any claims or adjustments proposed for any of Borrower’s prior tax years which could result in additional taxes becoming due and payable by Borrower. Borrower has paid all amounts necessary to
fund all present pension, profit sharing and deferred compensation plans in accordance with their terms, and Borrower has not withdrawn from participation in, and has not permitted partial or complete termination of, or permitted the occurrence of
any other event with respect to, any such plan which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency.

 5.9 Use of Proceeds. Borrower shall use the proceeds of the Credit Extensions solely as working capital, for strategic
acquisitions, licenses and repayment of all Indebtedness owing to GE (as expressly permitted hereunder), and to fund its general business requirements and not for personal, family, household or agricultural purposes. 
 5.10 Full Disclosure. No written representation, warranty or other statement of Borrower in any certificate or written statement given to
Collateral Agent or any Lender, as of the date such representation, warranty, or other statement was made, taken together with all such written certificates and written statements given to Collateral Agent or any Lender, contains any untrue
statement of a material fact or omits to state a material fact necessary to make the statements contained in the certificates or statements not misleading (it being recognized that the projections and forecasts provided by Borrower in good faith and
based upon reasonable assumptions are not viewed as facts and that actual results during the period or periods covered by such projections and forecasts may differ from the projected or forecasted results). 
  

	 	6	AFFIRMATIVE COVENANTS 

 Each Borrower shall
do all of the following: 
 6.1 Government Compliance. 
 (a) Maintain its and all its Subsidiaries’ legal existence and good standing in their respective jurisdictions of formation and
maintain qualification in each jurisdiction in which the failure to so qualify would reasonably be expected to have a material adverse effect on Borrower’s business or operations. Borrower shall comply, and have each Subsidiary comply, with all
laws, ordinances and regulations to which it is subject, noncompliance with which could have a material adverse effect on Borrower’s business. 
 (b) Obtain all of the Governmental Approvals necessary for the performance by Borrower of its obligations under the Loan Documents and Warrants to which it is a party and the grant of a security interest to Collateral
Agent for the ratable benefit of the Lenders, in all of its property. Borrower shall promptly provide copies of any such obtained Governmental Approvals to Collateral Agent. 
 6.2 Financial Statements, Reports, Certificates. 
 (a) Alphatec shall provide each Lender with the following: 
 (i) within twenty
(20) days after the end of each month, (A) a Transaction Report (and any schedules related thereto) (if there are no loan balances outstanding under the Revolving Line for the preceding calendar month), (B) monthly accounts receivable
agings, aged by invoice date, (C) monthly accounts payable agings, aged by invoice date, and outstanding or held check registers, if any, (D) monthly reconciliations of accounts receivable agings (aged by invoice date), transaction reports
and general ledger, (E) monthly perpetual inventory reports for Inventory valued on a first-in, first-out basis at the lower of cost or market (in accordance with GAAP) or such other inventory reports as are requested by Lenders in their good
faith business judgment; (F) a deferred revenue schedule; and (G) a report of the location, holders and value of all Consigned Collateral. 

 (ii) as soon as available, and in any event within thirty (30) days after the
end of each month, monthly unaudited financial statements of Alphatec; 
 (iii) within thirty (30) days after the
end of each quarter a quarterly Compliance Certificate signed by a Responsible Officer, certifying that as of the end of such quarter, Borrowers were in full compliance with all of the terms and conditions of this Agreement, and such other
information as Lenders shall reasonably request, including, without limitation, a statement that at the end of such month there were no held checks, and a calculation of the financial covenants set forth in Section 6.8 below; 
 (iv) the more frequent of weekly, by Monday of the following week, or with each request for a Revolving Advance when there are loan
balances outstanding under the Revolving Line for the preceding calendar month, a Transaction Report (and any schedules related thereto); 
 (v) within sixty (60) days after the beginning of each fiscal year of Borrowers, (A) annual operating budgets (including income statements, balance sheets and cash flow statements, by month) for such
fiscal year of Borrowers, and (B) annual financial projections for such fiscal year (on a quarterly basis), together with any related business forecasts used in the preparation of such annual financial projections; in each case, as approved by
each Borrower’s board of directors and provided to Borrowers’ equity investors; 
 (vi) as soon as available,
and in any event within one hundred eighty (180) days following the end of Alphatec’s fiscal year, annual financial statements certified by, and with an unqualified opinion of, independent certified public accountants acceptable to
Lenders; and 
 (vii) a prompt report of any legal actions pending or threatened in writing against a Borrower or any
Subsidiary that could result in damages or costs to a Borrower or any Subsidiary of Five Hundred Thousand Dollars ($500,000) or more. 
 (b) Parent shall provide each Lender with, as soon as available, but no later than five (5) days after filing with the Securities Exchange Commission, Parent’s 10K, 10Q, and 8K reports; 
 Parent’s 10K, 10Q, and 8K reports required to be delivered pursuant hereto shall be deemed to have been delivered on the date on which Parent posts
such report or provides a link thereto on Parent’s or another website (including www.sec.gov) on the Internet. 
 6.3 Accounts
Receivable. 
 (a) Schedules and Documents Relating to Accounts. Alphatec shall deliver to each Lender
transaction reports and schedules of collections, as provided in Section 6.2, on Bank’s standard forms; provided, however, that Alphatec’s failure to execute and deliver the same shall not affect or limit Lenders’ Lien and
other rights in all of Borrowers’ Accounts, nor shall any Lender’s failure to advance or lend against a specific Account affect or limit such Lender’s Lien and other rights therein. If requested by a Lender, each Borrower shall
furnish each Lender with copies (or, at a Lender’s request, originals) of all contracts, orders, invoices, and other similar documents, and all shipping instructions, delivery receipts, bills of lading, and other evidence of delivery, for any
goods the sale or disposition of which gave rise to such Accounts. In addition, each Borrower shall deliver to Lenders, on any Lender’s request, the originals of all instruments, chattel paper, security agreements, guarantees and other
documents and property evidencing or securing any Accounts, in the same form as received, with all necessary indorsements, and copies of all credit memos. 
 (b) Disputes. Each Borrower shall promptly notify Lenders of all disputes or claims exceeding Seventy Five Thousand Dollars ($75,000) relating to Accounts. Each Borrower may forgive (completely or partially),
compromise, or settle any Account for less than payment in full, or agree to do any of the foregoing so long as (i) such Borrower does so in good faith, in a 

 
commercially reasonable manner, in the ordinary course of business, in arm’s-length transactions, and reports the same to Lenders in the regular reports
provided to Lenders; (ii) no Default or Event of Default has occurred and is continuing; and (iii) after taking into account all such discounts, settlements and forgiveness, the total outstanding Advances will not exceed the lesser of the
Revolving Line or the Borrowing Base. 
 (c) Collection of Accounts. Each Borrower shall have the right to collect all
Accounts, unless and until a Default or an Event of Default has occurred and is continuing. Lenders shall require that all proceeds of Accounts be deposited by Borrowers into the Lockbox. Whether or not an Event of Default has occurred and is
continuing, each Borrower shall hold all payments on, and proceeds of, Accounts in trust for Lenders, and each Borrower shall immediately deliver all such payments and proceeds to Collateral Agent, for the ratable benefit of the Lenders according to
their respective Revolving Line Commitment Percentages, in their original form, duly endorsed, to be applied (i) prior to an Event of Default, pursuant to the terms of Section 2.4(f) hereof, and (ii) after the occurrence and
during the continuance of an Event of Default, pursuant to the terms of Section 9.4 hereof. 
 (d)
Returns. Provided no Event of Default has occurred and is continuing, if any Account Debtor returns any Inventory to a Borrower, such Borrower shall promptly (i) determine the reason for such return, (ii) issue a credit
memorandum to the Account Debtor in the appropriate amount, and (iii) provide a copy of such credit memorandum to Bank, for the benefit of the Lenders, upon request from any Lender. In the event any attempted return occurs after the occurrence
and during the continuance of any Event of Default, such Borrower shall hold the returned Inventory in trust for Lenders, and immediately notify Lenders of the return of the Inventory. 
 (e) Verification. Lenders may, from time to time, verify directly with the respective Account Debtors the validity, amount
and other matters relating to the Accounts, either in the name of a Borrower or any Lender or such other name as Lenders may choose. 
 (f) No Liability. Lenders shall not be responsible or liable for any shortage or discrepancy in, damage to, or loss or destruction of, any goods, the sale or other disposition of which gives rise to an Account, or for any
error, act, omission, or delay of any kind occurring in the settlement, failure to settle, collection or failure to collect any Account, or for settling any Account in good faith for less than the full amount thereof, nor shall any Lender be deemed
to be responsible for any of Borrowers’ obligations under any contract or agreement giving rise to an Account. Nothing herein shall, however, relieve Lenders from liability for its own gross negligence or willful misconduct. 
 6.4 Remittance of Proceeds. Except as otherwise provided in Section 6.3(c), deliver, in kind, all proceeds arising from the
disposition of any Collateral to Bank, for the ratable benefit of the Lenders, in the original form in which received by a Borrower not later than the following Business Day after receipt by a Borrower, to be applied to the Obligations pursuant to
the terms of Section 9.4 hereof; provided that, if no Default or Event of Default has occurred and is continuing, Borrowers shall not be obligated to remit to Bank the proceeds of the sale of worn out or obsolete Equipment disposed of by
a Borrower in good faith in an arm’s length transaction for an aggregate purchase price of One Hundred Thousand Dollars ($100,000) or less (for all such transactions in any fiscal year). Nothing in this Section limits the restrictions on
disposition of Collateral set forth elsewhere in this Agreement. 
 6.5 Taxes; Pensions. Timely file, and require each of its
Subsidiaries to timely file, all required tax returns and reports and timely pay, and require each of its Subsidiaries to timely file, all foreign, federal, state and local taxes, assessments, deposits and contributions owed by a Borrower and each
of its Subsidiaries, except for deferred payment of any taxes contested pursuant to the terms of Section 5.8 hereof, and shall deliver to Lenders, on demand, appropriate certificates attesting to such payments, and pay all amounts
necessary to fund all present pension, profit sharing and deferred compensation plans in accordance with their terms. 
 6.6 Access to
Collateral; Books and Records. At reasonable times, but not more than two (2) times per year (unless a Default or Event of Default has occurred and is continuing) on one (1) Business Day’s notice (provided no notice is
required if an Event of Default has occurred and is continuing), each Lender, or its agents, shall have the right to inspect the Collateral and the right to audit and copy each Borrower’s Books. The foregoing inspections and audits shall be at
Borrowers’ expense, and the charge therefor shall 

 
be Seven Hundred Fifty Dollars ($750) per person per day (or such higher amount as shall represent such Lender’s then-current standard charge for the
same), plus reasonable out-of-pocket expenses. In the event a Borrower and any Lender schedule an audit more than ten (10) days in advance, and such Borrower cancels or seeks to reschedule the audit with less than ten (10) days written
notice to Lenders, then (without limiting any of each Lender’s rights or remedies), such Borrower shall pay such Lender a fee of One Thousand Dollars ($1,000) plus any out-of-pocket expenses incurred by such Lender to compensate such Lender for
the anticipated costs and expenses of the cancellation or rescheduling. 
 6.7 Insurance. Keep its business and the Collateral insured
for risks and in amounts standard for companies in Borrowers’ industry and location and as Lenders may reasonably request. Insurance policies shall be in a form, with companies, and in amounts that are reasonably satisfactory to Lenders. All
property policies shall have a lender’s loss payable endorsement showing Collateral Agent as an additional lender loss payee and waive subrogation against Lenders, and all liability policies shall show, or have endorsements showing, Collateral
Agent as an additional insured. Alphatec will make commercially reasonable efforts to ensure that all policies (or the loss payable and additional insured endorsements) shall provide that the insurer must give Collateral Agent at least thirty
(30) days notice before canceling, amending, or declining to renew its policy. At Collateral Agent’s and any Lenders’ request, Borrowers shall deliver certified copies of policies and evidence of all premium payments. Proceeds payable
under any policy shall, at Lenders’ option, be payable to Lenders on account of the Obligations. Notwithstanding the foregoing, (a) so long as no Event of Default has occurred and is continuing, Borrowers shall have the option of applying
the proceeds of any casualty policy up to Five Hundred Thousand Dollars ($500,000) with respect to any loss toward the replacement or repair of destroyed or damaged property; provided that any such replaced or repaired property (i) shall be of
equal or like value as the replaced or repaired Collateral and (ii) shall be deemed Collateral in which Collateral Agent has been granted a first priority security interest, and (b) after the occurrence and during the continuance of an
Event of Default, all proceeds payable under such casualty policy shall, at the option of Lenders, be payable to Lenders on account of the Obligations. If a Borrower fails to obtain insurance as required under this Section 6.7 or to pay
any amount or furnish any required proof of payment to third persons and Collateral Agent, Collateral Agent may make all or part of such payment or obtain such insurance policies required in this Section 6.7, and take any action under
the policies Collateral Agent reasonably deems prudent. 
 6.8 Operating Accounts. 
 (a) Maintain its primary depository, operating and securities accounts with Bank or Bank’s Affiliates, which accounts shall represent
at least eighty five percent (85%) of the dollar value of each Borrower’s and each Borrower’s Subsidiaries’ accounts at all financial institutions; provided that Alphatec shall be permitted one hundred eighty (180) days from
the Effective Date to close its lockbox account with Bank of the West provided that no later than thirty (30) days after the Effective Date, such account is subject to an account control agreement in favor of Collateral Agent, for the benefit
of Lenders. 
 (b) Provide Collateral Agent five (5) days prior written notice before establishing any Collateral Account
at or with any bank or financial institution other than Bank or Bank’s Affiliates. In addition, for each Collateral Account that a Borrower or any Domestic Subsidiary at any time maintains, such Borrower shall cause the applicable bank or
financial institution (other than Bank) at or with which any Collateral Account is maintained to execute and deliver a Control Agreement or other appropriate instrument with respect to such Collateral Account to perfect Collateral Agent’s Lien
in such Collateral Account in accordance with the terms hereunder, which Control Agreement may not be terminated without prior written consent of the Lenders. The provisions of the previous sentence shall not apply to deposit accounts exclusively
used for payroll, payroll taxes and other employee wage and benefit payments to or for the benefit of a Borrower’s employees and identified to Collateral Agent by Borrowers as such. 
 6.9 Financial Covenants. Borrowers shall maintain, at all times, to be tested, as of the last day of each quarter, on a consolidated
basis with respect to Borrowers and their Subsidiaries: 
 (a) Performance to Plan. As of the last day of each quarter,
Borrowers’ Revenue for such quarter shall be at least eighty percent (80%) of Borrowers’ projected Revenue for such quarter as outlined in Borrowers’ projections attached hereto as Annex I. 

 (b) EBITDA. Borrowers’ shall achieve quarterly EBITDA of not less than the
following amounts for the respective periods: 
  

					
	 Measuring Period
	  	Minimum EBITDA	 
	 Quarter ending 12/31/08
	  	 	($1,000,000	)
	 Quarter ending 3/31/09
	  	$	1,350,000	 
	 Quarter ending 6/30/09
	  	$	2,500,000	 
	 Quarter ending 9/30/09
	  	$	3,250,000	 
	 Quarter ending 12/31/09
	  	$	4,000,000	 
	 Quarter ending 3/31/10 and each quarter thereafter
	  	$	5,000,000	 

 6.10 Protection of Intellectual Property Rights. Each Borrower shall: (a) protect,
defend and maintain the validity and enforceability of its intellectual property; (b) promptly advise Lenders in writing of material infringements of its material intellectual property; and (c) not allow any intellectual property material
to such Borrower’s business to be abandoned, forfeited or dedicated to the public without Lenders’ written consent. Notwithstanding the foregoing, in no event shall any Borrower be obligated to bring any action against any Person for
infringement of such Borrower’s intellectual property if, such intellectual property is not material to Borrower’s business, or in the good faith business judgment of such Borrower’s board of directors, such an action would be
impractical or imprudent. 
 6.11 Litigation Cooperation. From the date hereof and continuing through the termination of this
Agreement, make available to Collateral Agent upon reasonable terms, without expense to Collateral Agent, each Borrower and its officers, employees and agents and each Borrower’s books and records, to the extent that Collateral Agent may deem
them reasonably necessary to prosecute or defend any third-party suit or proceeding instituted by or against Collateral Agent with respect to any Collateral or relating to a Borrower. 
 6.12 Notices of Litigation and Default. Each Borrower will give prompt written notice to Collateral Agent of any litigation or governmental
proceedings pending or threatened (in writing) against such Borrower which would reasonably be expected to have a material adverse effect with respect to such Borrower. Without limiting or contradicting any other more specific provision of this
Agreement, promptly (and in any event within three (3) Business Days) upon a Borrower becoming aware of the existence of any Event of Default or event which, with the giving of notice or passage of time, or both, would constitute an Event of
Default, such Borrower shall give written notice to Collateral Agent of such occurrence, which such notice shall include a reasonably detailed description of such Event of Default or event which, with the giving of notice or passage of time, or
both, would constitute an Event of Default. 
 6.13 Creation/Acquisition of Subsidiaries. In the event a Borrower or Guarantor creates
or acquires any Subsidiary, such Borrower or Guarantor shall promptly notify Lenders of the creation or acquisition of such new Subsidiary and take all such action as may be reasonably required by Lenders to cause each such domestic Subsidiary to
guarantee the Obligations of Borrowers under the Loan Documents and grant a continuing pledge and security interest in and to the assets of such Subsidiary (substantially as described on Exhibit A hereto); and the applicable Borrower shall grant and
pledge to Lenders a perfected security interest in the Shares of each Subsidiary. 
 6.14 Further Assurances. Execute any further
instruments and take further action as Collateral Agent reasonably requests to perfect or continue Lenders’ Lien in the Collateral or to effect the purposes of this Agreement. Deliver to Collateral Agent, within ten (10) days after the
same are sent or received, copies of all correspondence, reports, documents and other filings with any Governmental Authority regarding compliance with or maintenance of Governmental Approvals or Requirements of Law or that could reasonably be
expected to have a material effect on any of the Governmental Approvals or otherwise on the operations of a Borrower or any of its Subsidiaries. 

	 	7	NEGATIVE COVENANTS 

 Neither Borrower shall
do any of the following without Collateral Agent’s prior written consent: 
 7.1 Dispositions. Convey, sell, lease, transfer or
otherwise dispose of (collectively, “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, except for Transfers (a) of Inventory in the ordinary course of business; (b) of
worn-out or obsolete Equipment; (c) in connection with Permitted Liens and Permitted Investments; (d) of non-exclusive licenses for the use of the property of Borrowers or their Subsidiaries in the ordinary course of business, and
(e) non-exclusive licenses of Borrowers’ intellectual property in the ordinary course of business to include licenses of product to partnerships in bona fide collaborations. 
 7.2 Changes in Business, Management, Ownership, or Business Locations. (a) Engage in or permit any of its Subsidiaries to engage in any
business other than the businesses currently engaged in by a Borrower and such Subsidiary, as applicable, or reasonably related thereto; (b) liquidate or dissolve; or (c) enter into any transaction or series of related transactions in
which the stockholders of a Borrower immediately prior to the first such transaction own less than sixty five percent (65%) of the voting stock of such Borrower immediately after giving effect to such transaction or related series of such
transactions (other than by the sale of a Borrower’s equity securities in a public offering or to venture capital investors so long as such Borrower identifies to Lenders the venture capital investors prior to the closing of the transaction).
Neither Borrower shall, without at least thirty (30) days prior written notice to Lenders: (1) add any new offices or business locations, including warehouses (unless (x) such new offices, business locations or warehouses contain less
than One Hundred Thousand Dollars ($100,000) in such Borrower’s assets or property, or (y) Borrower has delivered to Collateral Agent a bailee agreement in form and substance satisfactory to Collateral Agent in its sole discretion with
respect to such offices, business locations or warehouses), or (z) such warehouse consists of a drop-ship location that Borrower is using in the ordinary course of its business to store only Consigned Collateral, (2) change its
jurisdiction of organization, (3) change its organizational structure or type, (4) change its legal name, or (5) change any organizational number (if any) assigned by its jurisdiction of organization. 
 7.3 Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other Person, or acquire,
or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person. A Subsidiary may merge or consolidate into another Subsidiary or into a Borrower. 
 7.4 Indebtedness. Create, incur, assume, or be liable for any Indebtedness, or permit any Subsidiary to do so, other than Permitted Indebtedness.

 7.5 Encumbrance. Create, incur, or allow any Lien on any of its property, or assign or convey any right to receive income,
including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for Permitted Liens, or permit any Collateral not to be subject to the first priority security interest granted herein. Neither Borrower shall sell, transfer,
assign, mortgage, pledge, lease, grant a security interest in, or encumber, or enter into any agreement, document, instrument or other arrangement (except with or in favor of Collateral Agent) with any Person which directly or indirectly prohibits
or has the effect of prohibiting a Borrower or any Subsidiary from selling, transferring, assigning, mortgaging, pledging, leasing, granting a security interest in or upon, or encumbering any of a Borrower’s or any Subsidiary’s
intellectual property, except as is otherwise permitted in Section 7.1 hereof and the definition of “Permitted Liens” herein. 

 7.6 Maintenance of Collateral Accounts. Maintain any Collateral Account except pursuant to the
terms of Section 6.8(b) hereof. 
 7.7 Distributions; Investments. (a) Directly or indirectly make any
Investment other than Permitted Investments, or permit any of its Subsidiaries to do so; or (b) pay any dividends or make any distribution or payment or redeem, retire or purchase any capital stock provided that (i) each Borrower may pay
dividends solely in common stock; and (ii) each Borrower may repurchase the stock of former employees or consultants pursuant to stock repurchase agreements so long as an Event of Default does not exist at the time of such repurchase and would
not exist after giving effect to such repurchase, provided such repurchase does not exceed in the aggregate of Two Hundred Fifty Thousand Dollars ($250,000) per fiscal year. 
 7.8 Transactions with Affiliates. Except as disclosed in any filings under applicable securities laws, directly or indirectly enter into or permit
to exist any material transaction with any Affiliate of a Borrower, except for transactions that are in the ordinary course of a Borrower’s business, upon fair and reasonable terms that are no less favorable to such Borrower than would be
obtained in an arm’s length transaction with a non-affiliated Person. 
 7.9 Subordinated Debt. (a) Make or permit any
payment on any Subordinated Debt, except under the terms of the subordination, intercreditor, or other similar agreement to which such Subordinated Debt is subject, or (b) amend any provision in any document relating to the Subordinated Debt
which would increase the amount thereof or adversely affect the subordination thereof to Obligations owed to the Lenders. 
 7.10
Compliance. Become an “investment company” or a company controlled by an “investment company”, under the Investment Company Act of 1940 or undertake as one of its important activities extending credit to purchase or carry
margin stock (as defined in Regulation U of the Board of Governors of the Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA, permit a Reportable Event or
Prohibited Transaction, as defined in ERISA, to occur; fail to comply with the Federal Fair Labor Standards Act or violate any other law or regulation, if the violation could reasonably be expected to have a material adverse effect on a
Borrower’s business, or permit any of its Subsidiaries to do so; withdraw or permit any Subsidiary to withdraw from participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any
present pension, profit sharing and deferred compensation plan which could reasonably be expected to result in any liability of a Borrower, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other
governmental agency. 
 7.11 Indebtedness Payments. (i) Prepay, redeem, purchase, defease or otherwise satisfy in any manner
prior to the scheduled repayment thereof any Indebtedness for borrowed money (other than amounts due under this Agreement or due any Lender) or lease obligations, (ii) amend, modify or otherwise change the terms of any Indebtedness for borrowed
money or lease obligations so as to accelerate the scheduled repayment thereof or (iii) repay any notes to officers, directors or shareholders. 
  

	 	8	EVENTS OF DEFAULT 

 Any one of the following
shall constitute an event of default (an “Event of Default”) under this Agreement: 
 8.1 Payment Default. A Borrower
fails to (a) make any payment of principal or interest on any Credit Extension on its due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable (which three (3) day grace
period shall not apply to payments due on the Growth Capital Maturity Date or the Revolving Line Maturity Date, as applicable). During the grace period, the failure to cure the payment default is not an Event of Default (but no Credit Extension will
be made during the grace period); 
 8.2 Covenant Default. 
 (a) A Borrower fails or neglects to perform any obligation in Sections, 6.2, 6.5, 6.7, 6.8 or 6.9 or violates any covenant in
Section 7; or 
 (b) A Borrower fails or neglects to perform, keep, or observe any other term, provision,
condition, covenant or agreement contained in this Agreement or any Loan Documents, and as to any default (other than those specified in this Section 8) under such other term, provision, condition, covenant or agreement that can be
cured, has failed to cure the default within ten (10) days after the occurrence thereof; provided, however, that if the default cannot by its nature be cured within the ten (10) day period or cannot after diligent attempts by such Borrower
be cured within such ten (10) day period, and such default is likely to be cured 

 
within a reasonable time, then such Borrower shall have an additional period (which shall not in any case exceed thirty (30) days) to attempt to cure
such default, and within such reasonable time period the failure to cure the default shall not be deemed an Event of Default (but no Credit Extensions shall be made during such cure period). Grace periods provided under this Section shall not apply,
among other things, to financial covenants or any other covenants set forth in subsection (a) above; 
 8.3 Material Adverse
Change. A Material Adverse Change occurs; 
 8.4 Attachment. 
 (a) (i) The service of process seeking to attach, by trustee or similar process, any funds of a Borrower or of any entity under control of
a Borrower (including a Subsidiary) on deposit with Bank or any Bank Affiliate, or (ii) a notice of lien, levy, or assessment is filed against any of a Borrower’s assets by any government agency, and the same under subclauses (i) and
(ii) hereof are not, within ten (10) days after the occurrence thereof, discharged or stayed (whether through the posting of a bond or otherwise); provided, however, no Credit Extensions shall be made during any ten (10) day cure
period; and 
 (b) (i) any material portion of a Borrower’s assets is attached, seized, levied on, or comes into
possession of a trustee or receiver, or (ii) any court order enjoins, restrains, or prevents a Borrower from conducting any part of its business; 
 8.5 Insolvency. (a) a Borrower is unable to pay its debts (including trade debts) as they become due or otherwise becomes insolvent; (b) a Borrower begins an Insolvency Proceeding; or (c) an
Insolvency Proceeding is begun against a Borrower and not dismissed or stayed within forty-five (45) days (but no Credit Extensions shall be made while of any of the conditions described in clause (a) exist and/or until any Insolvency
Proceeding is dismissed); 
 8.6 Other Agreements. There is a default in any agreement to which a Borrower or any Guarantor is a party
with a third party or parties resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of One Hundred Thousand Dollars ($100,000) or that could reasonably be
expected to have a material adverse effect on a Borrower’s business; 
 8.7 Judgments. A final, nonappealable judgment or
judgments for the payment of money in an amount, individually or in the aggregate, of at least One Hundred Thousand Dollars ($100,000) (not covered by independent third-party insurance) shall be rendered against a Borrower and shall remain
unsatisfied and unstayed for a period of ten (10) days after the entry thereof (provided that no Credit Extensions will be made prior to the satisfaction or stay of such judgment); 
 8.8 Misrepresentations. A Borrower or any Person acting for a Borrower makes any material representation, warranty, or other statement now or
later in this Agreement, any Loan Document or in any writing delivered to Collateral Agent and/or any Lender or to induce Collateral Agent and/or Lenders to enter this Agreement or any Loan Document, and such representation, warranty, or other
statement is incorrect in any material respect when made; 
 8.9 Subordinated Debt. A default or breach occurs under any agreement
between a Borrower and any creditor of a Borrower that signed a subordination, intercreditor, or other similar agreement with Lenders, or any creditor that has signed such an agreement with Lenders breaches any terms of such agreement; 

8.10 Guaranty. (a) Any guaranty of any Obligations terminates or ceases for any reason to be in full force and effect; (b) any
Guarantor does not perform any obligation or covenant under any guaranty of the Obligations; (c) any circumstance described in Sections 8.3, 8.4, 8.5, 8.7, or 8.8 occurs with respect to any Guarantor, or (d) the liquidation, winding up, or
termination of existence of any Guarantor; 

 8.11 Governmental Approvals. Any Governmental Approval shall have been (a) revoked,
rescinded, suspended, modified in an adverse manner or not renewed in the ordinary course for a full term or (b) subject to any decision by a Governmental Authority that designates a hearing with respect to any applications for renewal of any
of such Governmental Approval or that could result in the Governmental Authority taking any of the actions described in clause (a) above, and such decision or such revocation, rescission, suspension, modification or non-renewal (i) has, or
could reasonably be expected to have, a Material Adverse Change, or (ii) adversely affects the legal qualifications of a Borrower or any of its Subsidiaries to hold such Governmental Approval in any applicable jurisdiction and such revocation,
rescission, suspension, modification or non-renewal could reasonably be expected to affect the status of or legal qualifications of a Borrower or any of its Subsidiaries to hold any Governmental Approval in any other jurisdiction. 
  

	 	9	RIGHTS AND REMEDIES 

 9.1 Rights and
Remedies. While an Event of Default occurs and continues Collateral Agent may, without notice or demand, do any or all of the following: 
 (a) declare all Obligations immediately due and payable (but if an Event of Default described in Section 8.5 occurs all Obligations are immediately due and payable without any action by Collateral Agent or
Lenders); 
 (b) stop advancing money or extending credit for either Borrower’s benefit under this Agreement or under any
other agreement between either Borrower and Collateral Agent and/or Lenders; 
 (c) demand that Borrowers (i) deposit
cash with Bank in an amount equal to the aggregate amount of any Letters of Credit remaining undrawn, as collateral security for the repayment of any future drawings under such Letters of Credit, and Borrowers shall forthwith deposit and pay such
amounts, and (ii) pay in advance all Letter of Credit fees scheduled to be paid or payable over the remaining term of any Letters of Credit; 
 (d) terminate any FX Forward Contracts; 
 (e) settle or adjust disputes and claims directly
with Account Debtors for amounts on terms and in any order that Collateral Agent considers advisable, notify any Person owing a Borrower money of Lenders’ security interest in such funds, and verify the amount of such account; 
 (f) make any payments and do any acts it considers necessary or reasonable to protect the Collateral and/or its security interest in the
Collateral. Each Borrower shall assemble the Collateral if Collateral Agent requests and make it available as Collateral Agent designates. Collateral Agent may enter premises where the Collateral is located, take and maintain possession of any part
of the Collateral, and pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its security interest and pay all expenses incurred. Each Borrower grants Collateral Agent a license to enter and occupy any of its
premises, without charge, to exercise any of Collateral Agent’s rights or remedies; 
 (g) apply to the Obligations any
(i) balances and deposits of Borrowers it holds, or (ii) any amount held by Collateral Agent or Lenders owing to or for the credit or the account of a Borrower; 
 (h) ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell the Collateral. Collateral
Agent is hereby granted a non-exclusive, royalty-free license or other right to use, without charge, each Borrower’s labels, patents, copyrights, mask works, rights of use of any name, trade secrets, trade names, trademarks, service marks, and
advertising matter, or any similar property as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in connection with Collateral Agent’s exercise of its rights under this Section,
each Borrower’s rights under all licenses and all franchise agreements inure to Collateral Agent for the benefit of the Lenders; 

 (i) place a “hold” on any account maintained with Collateral Agent or Lenders
and/or deliver a notice of exclusive control, any entitlement order, or other directions or instructions pursuant to any Control Agreement or similar agreements providing control of any Collateral; 
 (j) demand and receive possession of each Borrower’s Books; and 
 (k) exercise all rights and remedies available to Collateral Agent under the Loan Documents or at law or equity, including all remedies
provided under the Code (including disposal of the Collateral pursuant to the terms thereof). 
 9.2 Power of Attorney. Each Borrower
hereby irrevocably appoints Collateral Agent as its lawful attorney-in-fact, exercisable only upon the occurrence and during the continuance of an Event of Default, to: (a) endorse Borrower’s name on any checks or other forms of payment or
security; (b) sign such Borrower’s name on any invoice or bill of lading for any Account or drafts against Account Debtors; (c) settle and adjust disputes and claims about the Accounts directly with Account Debtors, for amounts and on
terms Collateral Agent determines reasonable; (d) make, settle, and adjust all claims under such Borrower’s insurance policies; (e) pay, contest or settle any Lien, charge, encumbrance, security interest, and adverse claim in or to
the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge the same; and (f) transfer the Collateral into the name of Collateral Agent or a third party as the Code permits. Each Borrower hereby
appoints Collateral Agent as its lawful attorney-in-fact to sign such Borrower’s name on any documents necessary to perfect or continue the perfection of Lenders’ security interest in the Collateral regardless of whether an Event of
Default has occurred until all Obligations (other than inchoate indemnity obligations) have been satisfied in full and Collateral Agent and Lenders are under no further obligation to make Credit Extensions hereunder. Collateral Agent’s
foregoing appointment as each Borrower’s attorney in fact, and all of Collateral Agent’s rights and powers, coupled with an interest, are irrevocable until all Obligations (other than inchoate indemnity obligations) have been fully repaid
and performed and Collateral Agent’s and Lenders’ obligation to provide Credit Extensions terminates. 
 9.3 Protective
Payments. If a Borrower fails to obtain the insurance called for by Section 6.7 or fails to pay any premium thereon or fails to pay any other amount which a Borrower is obligated to pay under this Agreement or any other Loan Document,
Collateral Agent may obtain such insurance or make such payment, and all amounts so paid by Collateral Agent are Lenders’ Expenses and immediately due and payable, bearing interest at the then highest applicable rate, and secured by the
Collateral. Collateral Agent will make reasonable efforts to provide Borrowers with notice of Collateral Agent obtaining such insurance at the time it is obtained or within a reasonable time thereafter. No payments by Collateral Agent are deemed an
agreement to make similar payments in the future or Collateral Agent’s waiver of any Event of Default. 
 9.4 Application of Payments
and Proceeds. Borrowers shall have no right to specify the order or the accounts to which Lenders shall allocate or apply any payments required to be made by a Borrower to any Lender or otherwise received by any Lender under this Agreement when
any such allocation or application is not specified elsewhere in this Agreement. If an Event of Default has occurred and is continuing, Lenders may apply any funds in their possession, whether from either Borrower’s account balances, payments,
proceeds realized as the result of any collection of Accounts or other disposition of the Collateral, or otherwise, to the Obligations in such order as Lenders shall determine in their sole discretion. Any surplus shall be paid to Borrowers by
credit to the Designated Deposit Account or to other Persons legally entitled thereto; Borrowers shall remain liable to Lenders for any deficiency. If any Lender, in its good faith business judgment, directly or indirectly enters into a deferred
payment or other credit transaction with any purchaser at any sale of Collateral, Lenders shall have the option, exercisable at any time, of either reducing the Obligations by the principal amount of the purchase price or deferring the reduction of
the Obligations until the actual receipt by Lenders of cash therefor. 
 9.5 Liability for Collateral. So long as the Collateral Agent
and Lenders comply with reasonable banking practices regarding the safekeeping of the Collateral in the possession or under the control of the Collateral Agent and Lenders, the Collateral Agent and Lenders shall not be liable or responsible for:
(a) the safekeeping of the Collateral; (b) any loss or damage to the Collateral; (c) any diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or other Person. Borrowers bear
all risk of loss, damage or destruction of the Collateral. 

 9.6 No Waiver; Remedies Cumulative. Collateral Agent’s failure, at any time or times, to
require strict performance by a Borrower of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Collateral Agent thereafter to demand strict performance and compliance herewith or therewith.
No waiver hereunder shall be effective unless signed by Collateral Agent and then is only effective for the specific instance and purpose for which it is given. Collateral Agent’s rights and remedies under this Agreement and the other Loan
Documents are cumulative. Collateral Agent has all rights and remedies provided under the Code, by law, or in equity. Collateral Agent’s exercise of one right or remedy is not an election, and Collateral Agent’s waiver of any Event of
Default is not a continuing waiver. Collateral Agent’s delay in exercising any remedy is not a waiver, election, or acquiescence. 
 9.7 Demand Waiver. Each Borrower waives demand, notice of default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts,
documents, instruments, chattel paper, and guarantees held by Collateral Agent on which a Borrower is liable. 
  

	 	10	NOTICES 

 All notices, consents, requests,
approvals, demands, or other communication by any party to this Agreement or any other Loan Document must be in writing and shall be deemed to have been validly served, given, or delivered: (a) upon the earlier of actual receipt and three
(3) Business Days after deposit in the U.S. mail, first class, registered or certified mail return receipt requested, with proper postage prepaid; (b) upon transmission, when sent by facsimile transmission; (c) one (1) Business
Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if hand-delivered by messenger, all of which shall be addressed to the party to be notified and sent to the address, facsimile number
indicated below. Each party may change its address or facsimile number by giving the other parties written notice thereof in accordance with the terms of this Section 10. 
  

			
	 If to Borrowers:
	  	ALPHATEC SPINE, INC.
		  	ALPHATEC HOLDINGS, INC.
		  	5818 El Camino Real
		  	Carlsbad, CA 92008
		  	Attn: Peter C. Wulff - Chief Financial Officer
		  	Tel: 760-494-6749
		  	Fax: 760-930-2513
		
	 If to Collateral Agent:
	  	Silicon Valley Bank
		  	4370 La Jolla Village Drive, Suite 860
		  	San Diego, CA 92121
		  	Attn: Andy Pelletier
		  	Tel.: (858) 784-3323
		  	Fax: (858) 622-1424
		
	 If to Oxford:
	  	Oxford Finance Corporation133 N. Fairfax Street
		  	Alexandria, VA 22314
		  	Attn: Tim A. Lex, Chief Operating Officer
		  	Tel.: (703) 519-4900
		  	Fax: (703) 519-5225

  

	 	11	CHOICE OF LAW, VENUE, JURY TRIAL WAIVER AND JUDICIAL REFERENCE 

 California law governs the Loan Documents without regard to principles of conflicts of law. Each Borrower, Collateral Agent and Lenders each submit to the exclusive jurisdiction of the State and Federal courts in
Santa Clara County, California; provided, however, that nothing in this Agreement shall be deemed to operate to preclude Collateral Agent from bringing suit or taking other legal action in any other jurisdiction to realize on the Collateral or any
other security for the Obligations, or to enforce a judgment or 

 
other court order in favor of Collateral Agent and Lenders. Each Borrower expressly submits and consents in advance to such jurisdiction in any action or
suit commenced in any such court, and each Borrower hereby waives any objection that it may have based upon lack of personal jurisdiction, improper venue, or forum non conveniens and hereby consents to the granting of such legal or equitable relief
as is deemed appropriate by such court. Each Borrower hereby waives personal service of the summons, complaints, and other process issued in such action or suit and agrees that service of such summons, complaints, and other process may be made by
registered or certified mail addressed to either Borrower at the address set forth in Section 10 of this Agreement and that service so made shall be deemed completed upon the earlier to occur of a Borrower’s actual receipt thereof
or three (3) days after deposit in the U.S. mails, proper postage prepaid. 
 TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, EACH
BORROWER, COLLATERAL AGENT AND LENDERS EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY
AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR THE PARTIES TO ENTER INTO THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 
 WITHOUT INTENDING IN ANY WAY TO LIMIT THE PARTIES’ AGREEMENT TO WAIVE THEIR RESPECTIVE RIGHT TO A TRIAL BY JURY, if the above waiver of the right to a trial by jury is not enforceable, the parties hereto agree
that any and all disputes or controversies of any nature between them arising at any time shall be decided by a reference to a private judge, mutually selected by the parties (or, if they cannot agree, by the Presiding Judge of the Santa Clara
County, California Superior Court) appointed in accordance with California Code of Civil Procedure Section 638 (or pursuant to comparable provisions of federal law if the dispute falls within the exclusive jurisdiction of the federal courts),
sitting without a jury, in Santa Clara County, California; and the parties hereby submit to the jurisdiction of such court. The reference proceedings shall be conducted pursuant to and in accordance with the provisions of California Code of Civil
Procedure Sec.Sec. 638 through 645.1, inclusive. The private judge shall have the power, among others, to grant provisional relief, including without limitation, entering temporary restraining orders, issuing preliminary and permanent injunctions
and appointing receivers. All such proceedings shall be closed to the public and confidential and all records relating thereto shall be permanently sealed. If during the course of any dispute, a party desires to seek provisional relief, but a judge
has not been appointed at that point pursuant to the judicial reference procedures, then such party may apply to the Santa Clara County, California Superior Court for such relief. The proceeding before the private judge shall be conducted in the
same manner as it would be before a court under the rules of evidence applicable to judicial proceedings. The parties shall be entitled to discovery which shall be conducted in the same manner as it would be before a court under the rules of
discovery applicable to judicial proceedings. The private judge shall oversee discovery and may enforce all discovery rules and order applicable to judicial proceedings in the same manner as a trial court judge. The parties agree that the selected
or appointed private judge shall have the power to decide all issues in the action or proceeding, whether of fact or of law, and shall report a statement of decision thereon pursuant to the California Code of Civil Procedure Sec. 644(a). Nothing in
this paragraph shall limit the right of any party at any time to exercise self-help remedies, foreclose against collateral, or obtain provisional remedies. The private judge shall also determine all issues relating to the applicability,
interpretation, and enforceability of this paragraph. 
  

	 	12	GENERAL PROVISIONS 

 12.1 Termination of
Revolving Line Prior to Revolving Line Maturity Date. The Revolving Line may be terminated prior to the Revolving Line Maturity Date by Borrowers (or any of them), effective two (2) Business Days after written notice of termination
is given to Lenders. Notwithstanding any such termination, Lenders’ liens and security interests in the Collateral shall continue until each Borrower fully satisfies its Obligations under the Loan Documents. If such termination is at a
Borrower’s election, or at either Lender’s election due to the occurrence and continuance of an Event of Default, Borrowers shall pay to Lenders, in addition to the payment of any other expenses or fees then-owing, a termination fee (the
“Revolving Line Termination Fee”) in an amount equal to (i) Four Hundred Fifty Thousand Dollars ($450,000), if such termination occurs on or prior to the first anniversary of the Effective Date; (ii) Three Hundred Thousand
Dollars ($300,000), if such termination occurs after the first anniversary of the Effective Date but on or prior to the second anniversary of the Effective Date and (iii) One Hundred Fifty Thousand Dollars ($150,000) if such termination occurs
after the second anniversary of the Effective Date; in each case, to be shared among the Lenders pro rata according to their Revolving Commitment Percentages of the Revolving Line. 

 12.2 Successors and Assigns. This Agreement binds and is for the benefit of the successors and
permitted assigns of each party. Borrowers may not assign this Agreement or any rights or obligations under it without Collateral Agent’s prior written consent (which may be granted or withheld in Collateral Agent’s reasonable discretion).
Lenders have the right, without the consent of or notice to either Borrower, to sell, transfer, assign, negotiate, or grant participation in all or any part of, or any interest in, Lenders’ obligations, rights, and benefits under this Agreement
and the other Loan Documents. 
 12.3 Indemnification; Expenses. Each Borrower agrees to indemnify, defend and hold Collateral Agent
and the Lenders and their respective directors, officers, employees, agents, attorneys, or any other Person affiliated with or representing Collateral Agent or the Lenders (each, an “Indemnified Person”) harmless against:
(a) all obligations, demands, claims, and liabilities (collectively, “Claims”) asserted by any other party in connection with the transactions contemplated by the Loan Documents; and (b) all losses or Lenders’
Expenses incurred, or paid by such Indemnified Person from, following, or arising from transactions between Collateral Agent, and/or Lenders and either Borrower (including reasonable attorneys’ fees and expenses), except to the extent that such
are Claims and/or losses directly caused by such Indemnified Person’s gross negligence or willful misconduct. 
 12.4 Time of
Essence. Time is of the essence for the performance of all Obligations in this Agreement. 
 12.5 Severability of Provisions. Each
provision of this Agreement is severable from every other provision in determining the enforceability of any provision. 
 12.6 Correction
of Loan Documents. Lenders may, after reasonable consultation with Borrowers, correct immaterial patent errors and fill in any blanks in this Agreement and the other Loan Documents consistent with the agreement of the parties. 
 12.7 Amendments in Writing; Integration. All amendments to this Agreement must be in writing signed by Collateral Agent, Lenders and Borrowers.
This Agreement and the other Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the
parties about the subject matter of this Agreement and the Loan Documents merge into this Agreement and the other Loan Documents. 
 12.8
Counterparts. This Agreement may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, are an original, and all taken together, constitute one Agreement.

 12.9 Borrowers’ Liability. Either Borrower may, acting singly, request Credit Extensions hereunder. Each Borrower
hereby appoints the other as agent for the other for all purposes hereunder, including with respect to requesting Credit Extensions hereunder. Each Borrower hereunder shall be obligated to repay all Credit Extensions made hereunder, regardless of
which Borrower actually receives said Credit Extension, as if each Borrower hereunder directly received all Credit Extensions. Notwithstanding any other provision of this Agreement or other related document, each Borrower irrevocably waives all
rights that it may have at law or in equity (including, without limitation, any law subrogating such Borrower to the rights of Lenders under this Agreement) to seek contribution, indemnification or any other form of reimbursement from any other
Borrower, or any other Person now or hereafter primarily or secondarily liable for any of the Obligations, for any payment made by a Borrower with respect to the Obligations in connection with this Agreement or otherwise and all rights that it might
have to benefit from, or to participate in, any security for the Obligations as a result of any payment made by a Borrower with respect to the Obligations in connection with this Agreement or otherwise. Any agreement providing for indemnification,
reimbursement or any other arrangement prohibited under this Section shall be null and void. If any payment is made to a Borrower in contravention of this Section, such Borrower shall hold such payment in trust for Lenders and such payment shall be
promptly delivered to Lenders for application to the Obligations, whether matured or unmatured. 

 12.10 Survival. All covenants, representations and warranties made in this Agreement continue in
full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) have been
satisfied. The obligation of each Borrower in Section 12.3 to indemnify Collateral Agent and each Lender shall survive until the statute of limitations with respect to such claim or cause of action shall have run. 
 12.11 Confidentiality. In handling any confidential information, Collateral Agent and each Lender shall exercise the same degree of care that it
exercises for its own proprietary information, but disclosure of information may be made: (a) to Lenders’ and Collateral Agent’s Subsidiaries or Affiliates; (b) to prospective transferees or purchasers of any interest in the
Credit Extensions (provided, however, Lenders and Collateral Agent shall use commercially reasonable efforts to obtain such prospective transferee’s or purchaser’s agreement to the terms of this provision); (c) as required by law,
regulation, subpoena, or other order; (d) to regulators or as otherwise required in connection with an examination or audit; and (e) as Collateral Agent considers appropriate in exercising remedies under the Loan Documents. Confidential
information does not include information that either: (i) is in the public domain or in Lenders’ and/or Collateral Agent’s possession when disclosed to Lenders and/or Collateral Agent, or becomes part of the public domain after
disclosure to Lenders and/or Collateral Agent; or (ii) is disclosed to Lenders and/or Collateral Agent by a third party, if Lenders and/or Collateral Agent does not know that the third party is prohibited from disclosing the information.

 Lenders and Collateral Agent may use confidential information for any purpose, including, without limitation, for the development of
client databases, reporting purposes, and market analysis, so long as Lenders and the Collateral Agent do not disclose either Borrower’s identity or the identity of any person associated with either Borrower unless otherwise expressly permitted
by this Agreement. The provisions of the immediately preceding sentence shall survive the termination of this Agreement. 
 12.12
Attorneys’ Fees, Costs and Expenses. In any action or proceeding between Borrowers, Collateral Agent and/or Lenders arising out of or relating to the Loan Documents, the prevailing party shall be entitled to recover its reasonable
attorneys’ fees and other costs and expenses incurred, in addition to any other relief to which it may be entitled. 
 12.13 Right of
Set Off. Each Borrower hereby grants to Collateral Agent and to each Lender, a lien, security interest and right of set off as security for all Obligations to Collateral Agent and each Lender hereunder, whether now existing or hereafter
arising upon and against all deposits, credits, Collateral and property, now or hereafter in the possession, custody, safekeeping or control of Collateral Agent or Lenders or any entity under the control of Collateral Agent or Lenders (including a
Collateral Agent affiliate) or in transit to any of them. At any time after the occurrence and during the continuance of an Event of Default, without demand or notice, Collateral Agent or Lenders may set off the same or any part thereof and apply
the same to any liability or obligation of Borrowers even though unmatured and regardless of the adequacy of any other Collateral securing the Obligations. ANY AND ALL RIGHTS TO REQUIRE COLLATERAL AGENT TO EXERCISE ITS RIGHTS OR REMEDIES WITH
RESPECT TO ANY OTHER COLLATERAL WHICH SECURES THE OBLIGATIONS, PRIOR TO EXERCISING ITS RIGHT OF SETOFF WITH RESPECT TO SUCH DEPOSITS, CREDITS OR OTHER PROPERTY OF BORROWERS ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY WAIVED. 
  

	 	13	DEFINITIONS 

 13.1 Definitions. As
used in this Agreement, the following terms have the following meanings: 
 “Account” is any “account” as defined
in the Code with such additions to such term as may hereafter be made, and includes, without limitation, all accounts receivable and other sums owing to a Borrower. 
 “Account Debtor” is any “account debtor” as defined in the Code with such additions to such term as may hereafter be made. 

 “Acquisition” is any sale, license, or other disposition of all or substantially all of
the assets of Parent, or any reorganization, consolidation, or merger of Parent where the holders of Parent’s securities before the transaction beneficially own less than fifty percent (50%) of the outstanding voting securities of the
surviving entity after the transaction. 
 “Affiliate” of any Person is a Person that owns or controls directly or
indirectly the Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited liability company,
that Person’s managers and members. 
 “Agreement” is defined in the preamble hereof. 
 “API” means Alphatec Pacific, Inc., a wholly owned Subsidiary of Parent organized under the laws of Japan. 
 “API Organizational Documents” means Articles of Incorporation of API (in Japanese and English), Regulations of the Board of Directors
of API (in Japanese and English), Share Handling Regulations of API, if any (in Japanese and English), Shareholder’s Register of API (in Japanese), Certified Copy of the Corporate Register of API (in Japanese and English), Seal Impression
Certificates of the Representative Certificate of API and Formalities Certificate (if necessary). 
 “API Share Pledge
Documents” means (i) the API Share Pledge Agreement and any related documents and (ii) resolutions of API authorizing such share pledge documents. 
 “Availability Amount” is (a) the lesser of (i) the Revolving Line or (ii) the amount available under the Borrowing Base minus (b) the amount of all outstanding Letters of Credit
(including drawn but unreimbursed Letters of Credit) plus an amount equal to the Letter of Credit Reserve, minus (c) the FX Reduction Amount, minus (d) any amounts used for Cash Management Services, and minus (e) the outstanding
principal balance of any Revolving Advances. 
 “Bank” is defined in the preamble hereof. 
 “Borrower” and “Borrowers” are defined in the preamble hereof. 
 “Borrower’s Books” are all of a Borrower’s books and records including ledgers, federal and state tax returns, records
regarding a Borrower’s assets or liabilities, the Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information. 
 “Borrowing Base” is (a) eighty percent (80%) of Eligible Accounts plus (b) the lesser of thirty percent (30%) of the
value of Alphatec’s Eligible Inventory (valued at the lower of cost or wholesale fair market value) or Three Million Dollars ($3,000,000), as determined by Lenders from Borrowers’ most recent Transaction Report; provided, however, that
Lenders may decrease the foregoing percentages in their good faith business judgment based on events, conditions, contingencies, or risks which, as determined by Lenders, may adversely affect Collateral. 
 “Borrowing Resolutions” are, with respect to any Person, those resolutions adopted by such Person’s Board of Directors and
delivered by such Person to Lenders approving the Loan Documents to which such Person is a party and the transactions contemplated thereby, together with a certificate executed by its secretary on behalf of such Person certifying that (a) such
Person has the authority to execute, deliver, and perform its obligations under each of the Loan Documents to which it is a party, (b) that attached as an exhibit to such certificate is a true, correct, and complete copy of the resolutions then
in full force and effect authorizing and ratifying the execution, delivery, and performance by such Person of the Loan Documents to which it is a party, (c) the name(s) of the Person(s) authorized to execute the Loan Documents on behalf of such
Person, together with a sample of the true signature(s) of such Person(s), and (d) that Lenders may conclusively rely on such certificate unless and until such Person shall have delivered to Lenders a further certificate canceling or amending
such prior certificate. 

 “Business Day” is any day that is not a Saturday, Sunday or a day on which Bank is
closed. 
 “Cash Management Services” is defined in Section 2.1.5. 
 “Code” is the Uniform Commercial Code, as the same may, from time to time, be enacted and in effect in the State of California;
provided, that, to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such term contained in Article or Division 9
shall govern; provided further, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority of, or remedies with respect to, Collateral Agent’s and Lenders’ Lien on any Collateral
is governed by the Uniform Commercial Code in effect in a jurisdiction other than the State of California, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely for purposes on
the provisions thereof relating to such attachment, perfection, priority, or remedies and for purposes of definitions relating to such provisions. 
 “Collateral” is any and all properties, rights and assets of each Borrower described on Exhibit A. 
 “Collateral Account” is any Deposit Account, Securities Account, or Commodity Account. 
 “Collateral
Agent” means Silicon Valley Bank, not in its individual capacity, but solely in its capacity as agent on behalf of and for the benefit of the Lenders. 
 “Commodity Account” is any “commodity account” as defined in the Code with such additions to such term as may hereafter be made. 
 “Compliance Certificate” is that certain certificate in the form attached hereto as Exhibit D. 
 “Consigned Collateral” means raw materials, Equipment and Inventory that has been (i) consigned to Borrowers’ third party
distribution agents and/or direct sales agents in the ordinary course of Borrowers’ business, or (ii) transferred to a drop-ship location in the ordinary course of Borrowers’ business. 
 “Contingent Obligation” is, for any Person, any direct or indirect liability, contingent or not, of that Person for (a) any
indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation directly or indirectly guaranteed, endorsed, co-made, discounted or sold with recourse by that Person, or for which that Person is directly or
indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all obligations from any interest rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other
agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; but “Contingent Obligation” does not include endorsements in the ordinary course of business. The
amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum reasonably anticipated liability for it determined by the Person in good
faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement. 
 “Control
Agreement” is any control agreement entered into among the depository institution at which a Borrower maintains a Deposit Account or the securities intermediary or commodity intermediary at which a Borrower maintains a Securities Account or
a Commodity Account, such Borrower, and Collateral Agent pursuant to which Collateral Agent obtains control (within the meaning of the Code) for the benefit of the Lenders over such Deposit Account, Securities Account, or Commodity Account.

 “Credit Extension” is the Growth Capital Advance, any Revolving Advance, Letter of Credit, FX Forward Contract, amount
utilized for Cash Management Services, or any other extension of credit by Lenders for a Borrower’s benefit. 
 “Default” means any event which with notice or passage of time or both, would constitute an Event of Default. 

 “Default Rate” is defined in Section 2.4(b). 
 “Deposit Account” is any “deposit account” as defined in the Code with such additions to such term as may hereafter be made.

 “Designated Deposit Account” is Alphatec’s deposit account, account number 3300650019, maintained with Bank.

 “Dollars,” “dollars” and “$” each mean lawful money of the United States. 

“EBITDA” means earnings before interest, taxes, depreciation, amortization, realized and unrealized foreign exchange gain and loss
and non-cash charges related to equity-based compensation and cash and non-cash in-process research and development expenses. The cash-based in-process research and development add-back, for purposes of this calculation, shall be limited to
$1,000,000 in any given quarter; plus up to (i) $1,750,000 for an OsseoScrew development milestone payment; (ii) $1,500,000 for an OsseoFix FDA approval/clearance milestone payment; (iii) $200,000 for a neuromonitoring system
milestone payment; and (iv) $1,000,000 for a neuromonitoring system FDA approval/clearance milestone payment. Cash-based in-process R&D payments in excess of the amounts set forth in the preceding sentence shall not be included in the
calculation of EBITDA. 
 “Effective Date” is defined in the preamble of this Agreement. 
 “Eligible Accounts” means Accounts which arise in the ordinary course of a Borrower’s business that meet all Borrowers’
representations and warranties in Section 5.2. Lenders reserve the right at any time after the Effective Date to adjust any of the criteria set forth below and to establish new criteria in its good faith business judgment. Eligible
Accounts shall not include: 
 (a) Accounts that the Account Debtor has not paid within ninety (90) days of invoice date
regardless of invoice payment period terms; 
 (b) Accounts owing from an Account Debtor, fifty percent (50%) or more of
whose Accounts have not been paid within ninety (90) days of invoice date; 
 (c) Accounts billed in the United States
and owing from an Account Debtor which does not have its principal place of business in the United States or Canada unless such Accounts are otherwise Eligible Accounts and (i) covered in full by credit insurance satisfactory to Lenders, less
any deductible, (ii) supported by letter(s) of credit acceptable to Lenders, (iii) supported by a guaranty from the Export-Import Bank of the United States, or (iv) that Lenders otherwise approve of in writing.; 
 (d) Accounts billed and payable outside of the United States unless the Lenders have a first priority, perfected security interest or
other enforceable Lien in such Accounts; 
 (e) Accounts owing from an Account Debtor to the extent that either Borrower is
indebted or obligated in any manner to the Account Debtor (as creditor, lessor, supplier or otherwise—sometimes called “contra” accounts, accounts payable, customer deposits or credit accounts), with the exception of customary
credits, adjustments and/or discounts given to an Account Debtor by a Borrower in the ordinary course of its business; 
 (f)
Accounts for which the Account Debtor is a Borrower’s Affiliate, officer, employee, or agent; 
 (g) Accounts with credit
balances over ninety (90) days from invoice date; 
 (h) Accounts owing from an Account Debtor, including Affiliates,
whose total obligations to a Borrower exceed twenty-five (25%) of all Accounts, for the amounts that exceed that percentage, unless Lenders approve in writing; 

 (i) Accounts owing from an Account Debtor which is a United States government entity or
any department, agency, or instrumentality thereof unless the applicable Borrower has assigned its payment rights to Lenders and the assignment has been acknowledged under the Federal Assignment of Claims Act of 1940, as amended; 
 (j) Accounts for demonstration or promotional equipment, or in which goods are consigned, or sold on a “sale guaranteed”,
“sale or return”, “sale on approval”, or other terms if Account Debtor’s payment may be conditional; 
 (k) Accounts owing from an Account Debtor that has not been invoiced or where goods or services have not yet been rendered to the Account Debtor (sometimes called memo billings or pre-billings); 
 (l) Accounts subject to contractual arrangements between a Borrower and an Account Debtor where payments shall be scheduled or due
according to completion or fulfillment requirements where the Account Debtor has a right of offset for damages suffered as a result of a Borrower’s failure to perform in accordance with the contract (sometimes called contracts accounts
receivable, progress billings, milestone billings, or fulfillment contracts); 
 (m) Accounts owing from an Account Debtor the
amount of which may be subject to withholding based on the Account Debtor’s satisfaction of a Borrower’s complete performance (but only to the extent of the amount withheld; sometimes called retainage billings); 
 (n) Accounts subject to trust provisions, subrogation rights of a bonding company, or a statutory trust; 
 (o) Accounts owing from an Account Debtor that has been invoiced for goods that have not been shipped to the Account Debtor unless
Lenders, the applicable Borrower, and the Account Debtor have entered into an agreement acceptable to Lenders in their sole discretion wherein the Account Debtor acknowledges that (i) it has title to and has ownership of the goods wherever
located, (ii) a bona fide sale of the goods has occurred, and (iii) it owes payment for such goods in accordance with invoices from the applicable Borrower (sometimes called “bill and hold” accounts); 
 (p) Accounts owing from an Account Debtor with respect to which a Borrower has received Deferred Revenue (but only to the extent of such
Deferred Revenue); 
 (q) Accounts for which the Account Debtor has not been invoiced; 
 (r) Accounts that represent non-trade receivables or that are derived by means other than in the ordinary course of a Borrower’s
business; 
 (s) Accounts for which a Borrower has permitted Account Debtor’s payment to extend beyond 90 days;

 (t) Accounts subject to chargebacks or others payment deductions taken by an Account Debtor (but only to the extent the
chargeback is determined invalid and subsequently collected by a Borrower); 
 (u) Accounts in which the Account Debtor
disputes liability or makes any claim (but only up to the disputed or claimed amount), or if the Account Debtor is subject to an Insolvency Proceeding, or becomes insolvent, or goes out of business; and 
 (v) Accounts for which Lenders in their good faith business judgment determines collection to be doubtful. 
 “Eligible Inventory” means Inventory that meets in all material respects all of Borrowers’ representations and warranties in
Section 5.2 and is finished goods Inventory located at Borrower’s leased facilities located at 5818 El Camino Real, Carlsbad, CA 92008, 6110 Corto Del Cedro, Carlsbad, CA 92008 and 5830 El Camino Real, Carlsbad, CA 92008. 

 “Equipment” is all “equipment” as defined in the Code with such additions to
such term as may hereafter be made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), personal computers, laptops, workstations, routers and other computer equipment, and any interest
in any of the foregoing 
 “ERISA” is the Employee Retirement Income Security Act of 1974, and its regulations. 

“Event of Default” is defined in Section 8. 
 “Foreign Currency” means lawful money of a country other than the United States. 
 “Funding Date” is any date on which a Credit Extension is made to or on account of a Borrower which shall be a Business
Day. 
 “FX Business Day” is any day when (a) Bank’s Foreign Exchange Department is conducting its normal
business and (b) the Foreign Currency being purchased or sold by a Borrower is available to Bank from the entity from which Bank shall buy or sell such Foreign Currency. 
 “FX Forward Contract” is defined in Section 2.1.4. 
 “FX Reduction Amount” is defined in Section 2.1.4. 
 “FX Reserve” is
defined in Section 2.1.4. 
 “GAAP” is generally accepted accounting principles set forth in the opinions and pronouncements
of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other Person as may be approved by a
significant segment of the accounting profession, which are applicable to the circumstances as of the date of determination. 
 “GE” means GE Business Financial Services, Inc. 
 “General Intangibles” is all “general
intangibles” as defined in the Code in effect on the date hereof with such additions to such term as may hereafter be made, and includes without limitation, all copyright rights, copyright applications, copyright registrations and like
protections in each work of authorship and derivative work, whether published or unpublished, any patents, trademarks, service marks and, to the extent permitted under applicable law, any applications therefor, whether registered or not, any trade
secret rights, including any rights to unpatented inventions, payment intangibles, royalties, contract rights, goodwill, franchise agreements, purchase orders, customer lists, route lists, telephone numbers, domain names, claims, income and other
tax refunds, security and other deposits, options to purchase or sell real or personal property, rights in all litigation presently or hereafter pending (whether in contract, tort or otherwise), insurance policies (including without limitation key
man, property damage, and business interruption insurance), payments of insurance and rights to payment of any kind. 
 “Governmental
Approval” is any consent, authorization, approval, order, license, franchise, permit, certificate, accreditation, registration, filing or notice, of, issued by, from or to, or other act by or in respect of, any Governmental Authority.

 “Governmental Authority” is any nation or government, any state or other political subdivision thereof, any agency,
authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative functions of or pertaining to government, any securities exchange and any
self-regulatory organization. 

 “Growth Capital Advance” is defined in Section 2.1.1(a). 
 “Growth Capital Amortization Date” means November 1, 2009. 
 “Growth Capital Commitment Percentage” means forty percent (40%) with respect to Bank, and sixty percent (60%) with respect to
Oxford. 
 “Growth Capital Final Payment” is a payment (in addition to and not a substitution for the regular monthly
payments of principal plus accrued interest) due on the earlier to occur of (a) the Growth Capital Maturity Date, (b) the acceleration of the Growth Capital Advance, or (c) the prepayment of the Growth Capital Advance, in the amount
of Seven Hundred Fifty Thousand Dollars ($750,000), to be shared pro rata among the Lenders according to their respective Growth Capital Commitment Percentages. 
 “Growth Capital Funding Date” is the date on which the Growth Capital Advance is made to or on account of Borrowers, which shall be the Effective Date or as soon thereafter as practical. 

“Growth Capital Interest Only Period” means, for the Growth Capital Advance, the period of time commencing on the Growth Capital
Funding Date through the day before the Growth Capital Amortization Date. 
 “Growth Capital Loan Commitment” is Fifteen
Million Dollars ($15,000,000). 
 “Growth Capital Maturity Date” is the earliest of (a) April 1, 2012, or
(b) the occurrence of an Event of Default. 
 “Growth Capital Repayment Period” is a period of time equal to thirty
(30) consecutive months commencing on the Growth Capital Amortization Date. 
 “Guarantor” means any guarantor of the
Obligations, including NexMed, Inc., a California corporation and wholly-owned Subsidiary of Parent. 
 “Guaranty” means
that certain Guaranty executed by Guarantor in favor of Lenders dated as of December 5, 2008. 
 “Indebtedness” is
(a) indebtedness for borrowed money or the deferred price of property or services, such as reimbursement and other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar
instruments, (c) capital lease obligations, and (d) Contingent Obligations. 
 “Insolvency Proceeding” is any
proceeding by or against any Person under the United States Bankruptcy Code, or any other bankruptcy or insolvency law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking
reorganization, arrangement, or other relief. 
 “Inventory” is all “inventory” as defined in the Code in effect
on the date hereof with such additions to such term as may hereafter be made, and includes without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including without
limitation such inventory as is temporarily out of a Borrower’s custody or possession or in transit and including any returned goods and any documents of title representing any of the above. 
 “Investment” is any beneficial ownership interest in any Person (including stock, partnership interest or other securities), and any
loan, advance or capital contribution to any Person. 
 “Lender” is any one of the Lenders. 
 “Lenders” shall mean the Persons identified in the preamble of this Agreement and each assignee that becomes a party to this Agreement
pursuant to Section 12.2. 

 “Lenders’ Expenses” are all audit fees and expenses, costs, and expenses (including
reasonable attorneys’ fees and expenses) for preparing, amending, negotiating, administering, defending and enforcing the Loan Documents and the Warrants (including, without limitation, those incurred in connection with appeals or Insolvency
Proceedings) or otherwise incurred with respect to a Borrower. 
 “Letter of Credit” means a standby letter of credit issued
by Bank or another institution based upon an application, guarantee, indemnity or similar agreement on the part of Bank as set forth in Section 2.1.3. 
 “Letter of Credit Application” is defined in Section 2.1.3(a). 
 “Letter of
Credit Reserve” has the meaning set forth in Section 2.1.3(g). 
 “Lien” is a claim, mortgage, lien, deed of trust,
levy, charge, pledge, security interest or other encumbrance. 
 “Loan Documents” are, collectively, this Agreement, the
Perfection Certificate, the Milverton Share Pledge Documents, the API Share Pledge Documents any Note, or Notes or guaranties and/or security agreements executed by a Borrower or any guarantor (including the Guaranty and the Security Agreement), and
any other present or future agreement, other than the Warrants, between a Borrower, any guarantor and/or for the benefit of Collateral Agent and/or any Lender in connection with this Agreement, all as amended, restated, or otherwise modified.

 “Material Adverse Change” is (a) a material impairment in the perfection or priority of Collateral Agent’s Lien
in the Collateral or in the value of such Collateral; (b) a material adverse change in the business, operations, or condition (financial or otherwise) of a Borrower; (c) a material impairment of the prospect of repayment of any portion of
the Obligations. or (d) Lenders determine, based upon information available to them and in their reasonable judgment, that there is a reasonable likelihood that Borrowers shall fail to comply with one or more of the financial covenants in
Section 6 during the next succeeding financial reporting period. 
 “Milverton” means Milverton Ltd., a wholly owned
subsidiary of Parent organized under the laws of Hong Kong. 
 “Milverton Organizational Documents” means the certified
Memorandum and Articles of Association (including all amendments), details of the directors and shareholders of Milverton and adjudicated declarations of trust (if any). 
 “Milverton Pledge Documents” means (i) that certain Equitable Mortgage Over Shares executed by Parent and Milverton and (ii) resolutions of Milverton authorizing the Equitable Mortgage Over
Shares. 
 “Net Income” means the consolidated net income of Borrowers and their Subsidiaries, determined in accordance with
GAAP. 
 “Note” means for the Growth Capital Advance and the Revolving Advances, one of the secured promissory notes of
Borrowers substantially in the form of Exhibit E. 
 “Obligations” are each Borrower’s obligation to pay when
due any debts, principal, interest, Lenders’ Expenses, Prepayment Fee, Growth Capital Final Payment, Growth Capital Loan Fee, Revolving Commitment Fee, Unused Revolving Line Facility Fee, Revolving Line Termination Fee and other amounts a
Borrower owes Lenders now or later, whether under this Agreement, the Loan Documents, or otherwise, including, without limitation, all obligations relating to letters of credit (including reimbursement obligations for drawn and undrawn letters of
credit), Cash Management Services, and foreign exchange contracts, if any, and including interest accruing after Insolvency Proceedings begin (whether or not allowed) and debts, liabilities, or obligations of a Borrower assigned to Lenders and/or
Collateral Agent, and the performance of each Borrower’s duties under the Loan Documents. 

 “Operating Documents” are, for any Person, such Person’s formation documents, as
certified with the Secretary of State of such Person’s state of formation on a date that is no earlier than 30 days prior to the Effective Date, and, (a) if such Person is a corporation, its bylaws in current form, (b) if such Person
is a limited liability company, its limited liability company agreement (or similar agreement), and (c) if such Person is a partnership, its partnership agreement (or similar agreement), each of the foregoing with all current amendments or
modifications thereto. 
 “Overadvance” is defined in Section 2.2. 
 “Payoff Letter” means that certain Payoff Letter executed by GE and Borrowers dated on or about the Effective Date. 
 “Payment” means all checks, wire transfers and other items of payment received by any Lender (including proceeds of Accounts and payment
of the Obligations in full) for credit to Borrowers’ outstanding Credit Extensions or, if the balance of the Credit Extensions has been reduced to zero, for credit to its Deposit Accounts. 
 “Payment/Advance Form” is that certain form attached hereto as Exhibit B. 
 “Perfection Certificate” is defined in Section 5.1. 
 “Permitted Indebtedness” is: 
 (a) Each Borrower’s Indebtedness to Lenders and Collateral Agent under this Agreement and the other Loan Documents; 
 (b) Indebtedness existing on the Effective Date and shown on the Perfection Certificate; 
 (c) Subordinated Debt; 
 (d) unsecured Indebtedness to trade creditors and with respect to surety bonds and similar
obligations incurred in the ordinary course of business; 
 (e) Indebtedness secured by Permitted Liens; 
 (f) extensions, refinancings, modifications, amendments and restatements of any items of Permitted Indebtedness (a) through
(e) above, provided that the then-outstanding principal amount thereof is not increased or the terms thereof are not modified to impose more burdensome terms upon a Borrower or its Subsidiary, as the case may be. 
 “Permitted Investments” are: 
 (a) Investments shown on the Perfection Certificate and existing on the Effective Date; 
 (b)
any Investments permitted by a Borrower’s investment policy, as amended from time to time, provided that such investment policy (and any such amendment thereto) has been approved by Lenders; 
 (c) Investments consisting of the endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary
course of a Borrower; 
 (d) Investments accepted in connection with Transfers permitted by Section 7.1;

 (e) Investments by a Borrower in a Guarantor or another Borrower and investments by a Guarantor in a Borrower; 

 (f) (i) Investments of Subsidiaries which are not Guarantors in or to other Subsidiaries
which are not Guarantor or a Borrower; and (ii) Investments by a Borrower in Subsidiaries which are not Guarantors not to exceed One Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year; 
 (g) Investments consisting of (i) travel advances and employee relocation loans and other employee loans and advances in the ordinary
course of business, and (ii) loans to employees, officers or directors relating to the purchase of equity securities of a Borrower or its Subsidiaries pursuant to employee stock purchase plans or agreements approved by a Borrower’s Board
of Directors which do not exceed Two Hundred Fifty Thousand Dollars ($250,000) in the aggregate in any year, provided that no cash loans under this clause (ii) may be made if an Event of Default is then occurring or would otherwise upon the
making thereof; 
 (h) Investments (including debt obligations) received in connection with the bankruptcy or reorganization
of customers or suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of business; and 
 (i) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers who are
not Affiliates, in the ordinary course of business; provided that this paragraph (i) shall not apply to Investments of a Borrower in any Subsidiary. 
 Notwithstanding the foregoing, Permitted Investments shall not include, and each Borrower and each Subsidiary is prohibited from purchasing, purchasing participations in, entering into any type of swap or other
equivalent derivative transaction, or otherwise holding or engaging in any ownership interest in any type of debt instrument, including, without limitation, any corporate or municipal bonds with a long-term nominal maturity for which the interest
rate is reset through a dutch auction and more commonly referred to as an “auction rate security.” 
 “Permitted
Liens” are: 
 (a) Liens existing on the Effective Date and shown on the Perfection Certificate or arising under this
Agreement and the other Loan Documents; 
 (b) Liens for taxes, fees, assessments or other government charges or levies,
either not delinquent or being contested in good faith and for which a Borrower maintains adequate reserves on its Books, if they have no priority over any of Collateral Agent’s and/or Lenders’ Liens; 
 (c) statutory Liens securing claims or demands of materialmen, mechanics, carriers, warehousemen, landlords and other Persons imposed
without action of such parties, provided, they have no priority over any of Collateral Agent’s and/or Lenders’ Liens and the aggregate amount of such Liens does not at any time exceed Two Million Dollars ($2,000,000) at all times through
June 30, 2009 and Two Hundred Fifty Thousand Dollars ($250,000) at all times thereafter; 
 (d) Liens to secure payment
of workers’ compensation, employment insurance, old-age pensions, social security and other like obligations incurred in the ordinary course of business, provided, they have no priority over any of Collateral Agent’s and/or Lenders’
Liens and the aggregate amount of the Indebtedness secured by such Liens does not at any time exceed One Hundred Thousand Dollars ($100,000); 
 (e) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (e), but any extension, renewal or replacement Lien must be limited to the property
encumbered by the existing Lien and the principal amount of the indebtedness may not increase; 
 (f) Easements, reservations,
rights-of-way, restrictions, minor defects or irregularities in title and similar charges or encumbrances affecting real property not constituting or reasonable likely to have a Material Adverse Change; 
 (g) Leases or subleases of real property granted in the ordinary course of business, and leases, subleases, non-exclusive licenses or
sublicenses of property (other than real property or intellectual property) granted in the ordinary course of a Borrower’s business, if the leases, subleases, licenses and sublicenses do not prohibit granting Collateral Agent and/or
Lenders a security interest; 

 (h) Liens arising from judgments, decrees or attachments in circumstances not
constituting an Event of Default under Section 8.4 or 8.7; 
 (i) Liens in favor of other financial institutions
arising in connection with a Borrower’s deposit and/or securities accounts held at such institutions, provided that such Borrower has complied with Section 6.8 hereof; and 
 (j) Purchase money Liens (i) on Equipment acquired or held by a Borrower incurred in connection with financing the acquisition of the
Equipment or (ii) existing on Equipment when acquired, if the Lien is confined to the property and improvements and the proceeds of the Equipment, in both cases, collectively, securing no more than One Million Dollars ($1,000,000) in the
aggregate amount outstanding. 
 “Person” is any individual, sole proprietorship, partnership, limited liability company,
joint venture, company, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or government agency. 
 “Prepayment Fee” shall be an additional fee payable to the Collateral Agent, for the ratable benefit of the Lenders according to their
respective Growth Capital Commitment Percentages, in amount equal to (i) three percent (3.00%) of the Growth Capital Advance if such prepayment occurs on or prior to the first anniversary of the Effective Date, (ii) two percent
(2.00%) of the Growth Capital Advance if such prepayment occurs after the first anniversary of the Effective Date, but on or prior to the second anniversary of the Effective Date or (iii) one percent (1.00%) of the Growth Capital
Advance if such prepayment occurs after the second anniversary of the Effective Date but on or prior to the third anniversary of the Effective Date. 
 “Prime Rate” is Bank’s most recently announced “prime rate,” even if it is not Bank’s lowest rate. 
 “Registered Organization” is any “registered organization” as defined in the Code with such additions to such term as may hereafter be made 
 “Requirement of Law” is as to any Person, the organizational or governing documents of such Person, and any law (statutory or common),
treaty, rule or regulation or determination of an arbitrator or a court or other Governmental Authority, in each case applicable to or binding upon such Person or any of its property or to which such Person or any of its property is subject.

 “Reserves” means, as of any date of determination, such amounts as Lenders may from time to time establish and revise in
their good faith business judgment, reducing the amount of Advances and other financial accommodations which would otherwise be available to a Borrower (a) to reflect events, conditions, contingencies or risks which, as determined by Lenders in
their good faith business judgment, do or may adversely affect (i) the Collateral or any other property which is security for the Obligations or its value (including without limitation any increase in delinquencies of Accounts), (ii) the
assets, business or prospects of a Borrower or any Guarantor, or (iii) the security interests and other rights of any Lender in the Collateral (including the enforceability, perfection and priority thereof); or (b) to reflect Lenders’
good faith belief that any collateral report or financial information furnished by or on behalf of a Borrower or any Guarantor to Lenders is or may have been incomplete, inaccurate or misleading in any material respect; or (c) in respect of any
state of facts which any Lender determines in good faith constitutes an Event of Default or may, with notice or passage of time or both, constitute an Event of Default. 
 “Responsible Officer” is any of the Chief Executive Officer, President, Chief Financial Officer and Secretary of each Borrower. 
 “Revenue” means the consolidated revenue of Borrowers and their Subsidiaries, determined in accordance with GAAP. 

 “Revolving Advance” or “Revolving Advances” means an advance (or
advances) under the Revolving Line. 
 “Revolving Commitment Percentage” means sixty percent (60%) with respect to SVB
and forty percent (40%) with respect to Oxford. 
 “Revolving Line” is a Revolving Advance or Revolving Advances in an
amount equal to Fifteen Million Dollars ($15,000,000). 
 “Revolving Line Maturity Date” is April 1, 2012. 

“Revolving Line Termination Fee” is defined in Section 12.1. 
 “Securities Account” is any “securities account” as defined in the Code with such additions to such term as may hereafter be
made. 
 “Security Agreement” means that certain Security Agreement executed by Guarantor, Collateral Agent, for the ratable
benefit of Lenders and Lenders dated as of December 5, 2008. 
 “Shares” means (i) sixty-five percent
(65%) of the issued and outstanding capital stock, membership units or other securities owned or held of record by a Borrower in any Subsidiary of such Borrower which is not an entity organized under the laws of the United States or any
territory thereof, and (ii) one hundred percent (100%) of the issued and outstanding capital stock, membership units or other securities owned or held of record by a Borrower in any Subsidiary of such Borrower which is an entity organized
under the laws of the United States or any territory thereof. 
 “Subordinated Debt” is indebtedness incurred by a Borrower
subordinated to all of such Borrower’s now or hereafter indebtedness to Lenders (pursuant to a subordination, intercreditor, or other similar agreement in form and substance satisfactory to Collateral Agent and Lenders entered into between
Collateral Agent, the applicable Borrower or Borrowers and the other creditor), on terms acceptable to and negotiated in good faith by Collateral Agent and Lenders. 
 “Subsidiary” means, with respect to any Person, any Person of which more than fifty percent (50%) of the voting stock or other equity interests is owned or controlled, directly or indirectly, by
such Person or one or more Affiliates of such Person. 
 “Transaction Report” is that certain report of transactions and
schedule of collections in the form attached hereto as Exhibit C. 
 “Transfer” is defined in
Section 7.1. 
 “Unused Revolving Line Facility Fee” is defined in Section 2.5(c). 
 “Warrants” are that certain Warrant to Purchase Stock dated on or about the Effective Date executed by Parent in favor of Bank and that
certain Warrant to Purchase Stock dated on or about the Effective Date executed by Parent in favor of Oxford. 
 [Balance of Page
Intentionally Left Blank] 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
Effective Date. 
  

			
	BORROWERS:
	
	ALPHATEC SPINE, INC.
		
	By	 	/s/ Peter C. Wulff
	Name:	 	Peter C. Wulff
	Title:	 	CFO, VP and Treasurer
	
	ALPHATEC HOLDINGS, INC.
		
	By	 	/s/ Peter C. Wulff
	Name:	 	Peter C. Wulff
	Title:	 	CFO, VP and Treasurer
	
	COLLATERAL AGENT:
	
	SILICON VALLEY BANK
		
	By	 	/s/ Andre P. Pelletier
	Name:	 	Andre P. Pelletier
	Title:	 	Senior Relationship Manager
	
	LENDERS:
	
	SILICON VALLEY BANK
		
	By	 	/s/ Andre P. Pelletier
	Name:	 	Andre P. Pelletier
	Title:	 	Senior Relationship Manager
	
	OXFORD FINANCE CORPORATION
		
	By	 	/s/ T.A. Lox
	Name:	 	T.A. Lox
	Title:	 	COO

 [Signature Page to Loan and Security Agreement] 

 EXHIBIT A 
 The Collateral consists of all of Borrower’s right, title and interest in and to the following personal property: 
 All goods, Accounts (including health-care receivables), Equipment, Inventory, contract rights or rights to payment of money, leases, license agreements, franchise agreements, General Intangibles (except as provided
below), commercial tort claims, documents, instruments (including any promissory notes), chattel paper (whether tangible or electronic), cash, deposit accounts, certificates of deposit, fixtures, letters of credit rights (whether or not the letter
of credit is evidenced by a writing), securities, and all other investment property, supporting obligations, and financial assets, whether now owned or hereafter acquired, wherever located; and all Borrower’s Books relating to the foregoing,
and any and all claims, rights and interests in any of the above and all substitutions for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of any or all of the
foregoing. 
 Notwithstanding the foregoing, the Collateral does not include any of the following, whether now owned or hereafter acquired,
any copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work, whether published or unpublished, any patents, patent applications and like protections, including
improvements, divisions, continuations, renewals, reissues, extensions, and continuations-in-part of the same, trademarks, service marks and, to the extent permitted under applicable law, any applications therefor, whether registered or not, and the
goodwill of the business of Borrower connected with and symbolized thereby, know-how, operating manuals, trade secret rights, rights to unpatented inventions, and any claims for damage by way of any past, present, or future infringement of any of
the foregoing; provided, however, the Collateral shall include all Accounts, license and royalty fees and other revenues, proceeds, or income arising out of or relating to any of the foregoing. 
 Pursuant to the terms of a certain negative pledge arrangement with Collateral Agent and Lenders, Borrower has agreed not to encumber any of its
copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work, whether published or unpublished, any patents, patent applications and like protections, including improvements,
divisions, continuations, renewals, reissues, extensions, and continuations-in-part of the same, trademarks, service marks and, to the extent permitted under applicable law, any applications therefor, whether registered or not, and the goodwill of
the business of Borrower connected with and symbolized thereby, know-how, operating manuals, trade secret rights, rights to unpatented inventions, and any claims for damage by way of any past, present, or future infringement of any of the foregoing,
without Collateral Agent’s prior written consent. 

 EXHIBIT B 
 Loan Payment/Advance Request Form 
 DEADLINE FOR
SAME DAY PROCESSING IS NOON P.S.T. 
  

	 Fax To: 
	 Date: _____________________ 

 LOAN PAYMENT: 
 ALPHATEC SPINE, INC. and ALPHATEC HOLDINGS, INC. 
  

			
	From Account #______________________________	  	To Account #______________________________________
	                                        
(Deposit Account #)	  	                                        
            (Loan Account #)
		
	Principal $__________________________________	  	and/or Interest $_____________________________________
		
	Authorized Signature: ________________________	  	Phone Number: _____________________________________
		
	  
 Print Name/Title: _____________________________
	  	

 LOAN ADVANCE: 
 Complete Outgoing Wire Request section below if all or a portion of the funds from this loan advance are for an outgoing wire. 
  

			
	From Account #______________________________	  	To Account #______________________________________
	                                        
(Loan Account #)	  	                                        
            (Deposit Account #)
		
	Amount of Advance $__________________________	  	

 All Borrowers’ representations and warranties in the Loan and Security Agreement are true, correct and
complete in all material respects on the date of the request for an advance; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in
the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date: 
  

			
	Authorized Signature: ________________________	  	Phone Number: _____________________________________
		
	  
 Print Name/Title: _____________________________
	  	

 OUTGOING WIRE REQUEST: 
 Complete only if all or a portion of funds from the loan advance above is to be wired. 
 Deadline for same day processing is noon, P.S.T. 
  

			
	Beneficiary Name: ______________________________	  	Amount of Wire: $__________________________________
		
	Beneficiary Lender: ______________________________	  	Account Number: ___________________________________
		
	City and State: ___________________________________	  	
		
	Beneficiary Lender Transit (ABA) #: ________________	  	Beneficiary Lender Code (Swift, Sort, Chip, etc.): __________
		  	            (For International Wire Only)
		
	Intermediary Lender: _____________________________	  	Transit (ABA) #: ____________________________________
	
	For Further Credit to: _____________________________________________________________________________________
	
	Special Instruction: _______________________________________________________________________________________

 By signing below, I (we) acknowledge and agree that my (our) funds transfer request shall be processed in
accordance with and subject to the terms and conditions set forth in the agreements(s) covering funds transfer service(s), which agreements(s) were previously received and executed by me (us). 
  

			
	Authorized Signature: _____________________________	  	2nd Signature (if required): ______________________________
		
	Print Name/Title: _________________________________	  	Print Name/Title: _____________________________________
		
	Telephone #: ____________________________________	  	Telephone #: _________________________________________

 EXHIBIT C 
 Transaction Report 
 [Excel spreadsheet to be provided from Lenders] 

 EXHIBIT D 
 COMPLIANCE CERTIFICATE 
  

	TO:	SILICON VALLEY BANK, as Collateral Agent 

	Date:	                         

	FROM: 	ALPHATEC SPINE, INC. and ALPHATEC HOLDINGS, INC. 

 The
undersigned authorized officer of ALPHATEC SPINE, INC. (“Alphatec”) certifies on behalf of Alphatec and ALPHATEC HOLDINGS, INC. (“Parent” and together with Alphatec each a “Borrower” and collectively,
“Borrowers”) that under the terms and conditions of the Loan and Security Agreement between Borrowers, Collateral Agent and the Lenders (the “Agreement”), (1) Each Borrower is in complete compliance for the period ending
                         with all required covenants except as noted below, (2) there are no Events of Default,
(3) all representations and warranties in the Agreement are true and correct in all material respects on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any representations and
warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material
respects as of such date, (4) Each Borrower, and each of its Subsidiaries, has timely filed all required tax returns and reports, and each Borrower has timely paid all foreign, federal, state and local taxes, assessments, deposits and
contributions owed by such Borrower except as otherwise permitted pursuant to the terms of Section 5.8 of the Agreement, and (5) no Liens have been levied or claims made against either Borrower or any of their Subsidiaries relating
to unpaid employee payroll or benefits of which such Borrower has not previously provided written notification to Collateral Agent. Attached are the required documents supporting the certification. The undersigned certifies that these are prepared
in accordance with generally GAAP consistently applied from one period to the next except as explained in an accompanying letter or footnotes. The undersigned acknowledges that no borrowings may be requested at any time or date of determination that
Borrowers are not in material compliance with any of the terms of the Agreement, and that compliance is determined not just at the date this certificate is delivered. Capitalized terms used but not otherwise defined herein shall have the meanings
given them in the Agreement. 
 Please indicate compliance status by circling Yes/No under “Complies” column. 
  

					
	 Reporting Covenant
	  	 Required
	  	Complies
			
	 Monthly A/R and A/P agings, reconciliations and
 Transaction Report, deferred revenue schedule, inventory report and Consigned Collateral report
	  	Monthly within 20 days	  	Yes  No
			
	Monthly financial statements with Compliance Certificate	  	Monthly within 30 days	  	Yes  No
			
	Annual financial statement (CPA Audited) + CC	  	FYE within 180 days	  	Yes  No
			
	Annual projections	  	60 days after FYE	  	Yes  No
			
	Transaction Report (when no Advances outstanding)	  	More frequent of weekly or with each request for an Advance	  	Yes  No
			
	10-Q, 10-K and 8-K	  	Within 5 days after filing with SEC	  	Yes  No

 Revenue for two prior quarters (to determine interest rate for Revolving Advances) 
 Revenue for quarter ending
              $                     
 Revenue for quarter ending
              $                     

 The following are the exceptions with respect to the certification above: (If no exceptions exist, state “No
exceptions to note.”) 
 The following analysis and information set forth in Schedule 1 attached hereto are true and accurate as of the date of this
Certificate. 
  
  
  
  
  
  
  
  

									
	ALPHATEC SPINE, INC.	 		 	LENDERS’ USE ONLY
					
		 		 		 	Received by:	 	 
	By:	 	 	 		 		 	AUTHORIZED SIGNER
	Name:	 	 	 		 	Date:	 	 
	Title:	 	 	 		 		 	
		 		 		 	Verified:	 	 
		 		 		 		 	AUTHORIZED SIGNER
		 		 		 	Date:	 	 
				
		 		 		 	Compliance Status:     Yes  No

 Schedule 1 to Compliance Certificate 
 EBITDA is calculated as follows: 
  

						
	A.	  	 Earnings of Borrowers and their Subsidiaries
	  	$	_______
			
	B.	  	 Interest paid by Borrowers and their Subsidiaries
	  	$	_______
			
	C.	  	 Taxes paid by Borrowers and their Subsidiaries
	  	$	_______
			
	D.	  	 Depreciation attributable to Borrowers and their Subsidiaries
	  	$	_______
			
	E.	  	 Amortization attributable to Borrowers and their Subsidiaries
	  	$	_______
			
	F.	  	 Non-cash charges related to equity-based compensation
	  	$	_______
			
	G.	  	 Cash and Non-cash charges related to in-process research and development
	  	$	_______
			
	H.	  	 Realized and unrealized foreign exchange gain or loss
	  	$	_______
			
	I.	  	 EBITDA (line A plus line B plus line C plus line D plus line E plus line F plus line G plus line H)
	  	$	_______

 Is line I equal to or greater than the amounts required below? 
  ̈  Yes, in
compliance                                        
                                      ̈
  No, not in compliance. 

 ANNEX I 
 (Projections) 
 [hard copy to be inserted] 

 EXHIBIT E 
 SECURED PROMISSORY NOTE 
  

			
	$________	  	Dated: December 5, 2008

 FOR VALUE RECEIVED, the undersigned, ALPHATEC SPINE, INC., a California corporation and ALPHATEC
HOLDINGS, INC., a Delaware corporation (each a “Borrower” and collectively, “Borrower”), HEREBY PROMISE TO PAY to the order of [SILICON VALLEY BANK][OXFORD FINANCE CORPORATION] (“Lender”) the
principal amount of [            Dollars ($            )] or such lesser amount as shall equal the outstanding
principal balance of the [Growth Capital][Revolving] Advance] made to Borrowers by Lender, plus interest on the aggregate unpaid principal amount of the [Growth Capital][Revolving] Advance, at the rates and in accordance with the terms of the Loan
and Security Agreement by and between Borrowers and Silicon Valley Bank, as Collateral Agent, and the Lenders, including without limitation, Oxford Finance Corporation (as amended, restated, supplemented or otherwise modified from time to time, the
“Loan Agreement”). If not sooner paid, the entire principal amount and all accrued interest hereunder and under the Loan Agreement shall be due and payable on [Growth Capital][Revolving] Maturity Date as set forth in the Loan Agreement

 Principal, interest and all other amounts due with respect to the [Growth Capital][Revolving] Advance, are payable in lawful money of the
United States of America to Lender as set forth in the Loan Agreement. The principal amount of this Note and the interest rate applicable thereto, and all payments made with respect thereto, shall be recorded by Lender and, prior to any transfer
hereof, endorsed on the grid attached hereto which is part of this Note. 
 This Note is one of the Notes referred to in, and is entitled to
the benefits of, the Loan and Security Agreement, dated as of December 5, 2008, to which Borrowers and Lender are parties (the “Loan Agreement”). The Loan Agreement, among other things, (a) provides for the making of this
secured Growth Capital Advance to Borrowers, and (b) contains provisions for acceleration of the maturity hereof upon the happening of certain stated events. 
 This Note may not be prepaid except as provided in the Loan Agreement. This Note and the obligation of Borrowers to repay the unpaid principal amount of the [Growth Capital][Revolving] Advance, interest on the [Growth
Capital][Revolving] Advance and all other amounts due Lenders under the Loan Agreement is secured under the Loan Agreement. 
 Presentment
for payment, demand, notice of protest and all other demands and notices of any kind in connection with the execution, delivery, performance and enforcement of this Note are hereby waived. 
 Borrowers shall pay all reasonable fees and expenses, including, without limitation, reasonable attorneys’ fees and costs, incurred by Lenders in
the enforcement or attempt to enforce any of Borrowers’ obligations hereunder not performed when due. This Note shall be governed by, and construed and interpreted in accordance with, the laws of the State of California. 
 [Remainder of page left intentionally blank; signature page follows] 

 IN WITNESS WHEREOF, each Borrower has caused this Note to be duly executed by one of its officers
thereunto duly authorized on the date hereof. 
  

			
	ALPHATEC SPINE, INC.
		
	By:	 	 
		
	Name:	 	 
		
	Title:	 	 
	
	ALPHATEC HOLDINGS, INC.
		
	By:	 	 
		
	Name:	 	 
		
	Title:	 	 

 [Signature Page to Secured Promissory Note] 

 LOAN INTEREST RATE AND PAYMENTS OF PRINCIPAL 
  

									
	Date	  	Principal
Amount	  	Interest Rate	  	Scheduled
Payment Amount	  	Notation By
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	

 BORROWING RESOLUTIONS 
 CORPORATE BORROWING CERTIFICATE 
  

							
	BORROWER:	    	ALPHATEC SPINE, INC.	 		  	DATE: December 5, 2008
		
	LENDERS:	    	Silicon Valley Bank (“Bank”) and Oxford Finance Corporation (collectively, “Lenders”)

 I hereby certify as follows, as of the date set forth above: 
 1. I am the Secretary, Assistant Secretary or other officer of Borrower. My title is as set forth below. 
 2. Borrower’s exact legal name is set forth above. Borrower is a corporation existing under the laws of the State of California. 
 3. Attached hereto are true, correct and complete copies of Borrower’s Articles/Certificate of Incorporation (including amendments), as filed with the Secretary of State of the state in which Borrower is
incorporated as set forth in paragraph 1 above. Such Articles/Certificate of Incorporation have not been amended, annulled, rescinded, revoked or supplemented, and remain in full force and effect as of the date hereof. 
 4. The following resolutions were duly and validly adopted by Borrower’s Board of Directors at a duly held meeting of such directors (or pursuant to a unanimous
written consent or other authorized corporate action). Such resolutions are in full force and effect as of the date hereof and have not been in any way modified, repealed, rescinded, amended or revoked, and Bank may rely on them until Bank receives
written notice of revocation from Borrower. 
 RESOLVED, that any one of the following officers or
employees of Borrower, whose names, titles and signatures are below, may act on behalf of Borrower: 
  

											
	 Name
	  	  	  	 Title
	  	  	  	 Signature
	  	 Authorized to
Add or Remove
Signatories

						
	 	  		  	 	  		  	 	  	 ̈
						
	 	  		  	 	  		  	 	  	 ̈
						
	 	  		  	 	  		  	 	  	 ̈
						
	 	  		  	 	  		  	 	  	 ̈

 RESOLVED FURTHER, that any one of the persons
designated above with a checked box beside his or her name may, from time to time, add or remove any individuals to and from the above list of persons authorized to act on behalf of Borrower. 
 RESOLVED FURTHER, that such individuals may, on behalf of Borrower: 
 Borrow Money. Borrow money from Lenders. 
 Execute Loan Documents. Execute any loan documents any Lender requires. 
 Grant Security. Grant Lenders a security
interest in any of Borrower’s assets. 
 Negotiate Items. Negotiate or discount all drafts, trade acceptances, promissory notes,
or other indebtedness in which Borrower has an interest and receive cash or otherwise use the proceeds. 
 Letters of Credit. Apply for
letters of credit from Bank. 
 Foreign Exchange Contracts. Execute spot or forward foreign exchange contracts. 

 Further Acts. Designate other individuals to request advances, pay fees and costs and execute
other documents or agreements (including documents or agreement that waive Borrowers right to a jury trial) they believe to be necessary to effectuate such resolutions. 
 RESOLVED FURTHER, that all acts authorized by the above resolutions and any prior acts relating thereto are ratified. 
 5. The persons listed above are Borrower’s officers or employees with their titles and signatures shown next to their names. 
  

			
	By:	 	 
	Name:	 	 
	Title:	 	 

 *** If the Secretary, Assistant Secretary or other certifying officer executing above is
designated by the resolutions set forth in paragraph 4 as one of the authorized signing officers, this Certificate must also be signed by a second authorized officer or director of Borrower. 
  

	
	 I, the __________________________ of Borrower, hereby certify as to paragraphs 1 through 5 above, as of the date

	 [print title]

	set forth above.

  

			
	By:	 	 
	Name:	 	 
	Title:	 	 

 BORROWING RESOLUTIONS 
 CORPORATE BORROWING CERTIFICATE 
  

							
	BORROWER:	    	ALPHATEC HOLDINGS, INC.	 		  	DATE: December 5, 2008
		
	LENDERS:	    	Silicon Valley Bank (“Bank”) and Oxford Finance Corporation (collectively, “Lenders”)

 I hereby certify as follows, as of the date set forth above: 
 1. I am the Secretary, Assistant Secretary or other officer of Borrower. My title is as set forth below. 
 2. Borrower’s exact legal name is set forth above. Borrower is a corporation existing under the laws of the State of Delaware. 
 3. Attached hereto are true, correct and complete copies of Borrower’s Articles/Certificate of Incorporation (including amendments), as filed with the Secretary of State of the state in which Borrower is incorporated as set forth in
paragraph 1 above. Such Articles/Certificate of Incorporation have not been amended, annulled, rescinded, revoked or supplemented, and remain in full force and effect as of the date hereof. 
 4. The following resolutions were duly and validly adopted by Borrower’s Board of Directors at a duly held meeting of such directors (or pursuant to a unanimous
written consent or other authorized corporate action). Such resolutions are in full force and effect as of the date hereof and have not been in any way modified, repealed, rescinded, amended or revoked, and Bank may rely on them until Bank receives
written notice of revocation from Borrower. 
 RESOLVED, that any one of the following officers or
employees of Borrower, whose names, titles and signatures are below, may act on behalf of Borrower: 
  

											
	 Name
	  	  	  	 Title
	  	  	  	 Signature
	  	 Authorized to
Add or Remove
Signatories

						
	 	  		  	 	  		  	 	  	 ̈
						
	 	  		  	 	  		  	 	  	 ̈
						
	 	  		  	 	  		  	 	  	 ̈
						
	 	  		  	 	  		  	 	  	 ̈

 RESOLVED FURTHER, that any one of the persons
designated above with a checked box beside his or her name may, from time to time, add or remove any individuals to and from the above list of persons authorized to act on behalf of Borrower. 
 RESOLVED FURTHER, that such individuals may, on behalf of Borrower: 
 Borrow Money. Borrow money from Lenders. 
 Execute Loan Documents. Execute any loan documents any Lender requires. 
 Grant Security. Grant Lenders a security
interest in any of Borrower’s assets. 
 Negotiate Items. Negotiate or discount all drafts, trade acceptances, promissory notes,
or other indebtedness in which Borrower has an interest and receive cash or otherwise use the proceeds. 
 Letters of Credit. Apply for
letters of credit from Bank. 
 Foreign Exchange Contracts. Execute spot or forward foreign exchange contracts. 
 Issue Warrants. Issue warrants for Borrower’s capital stock. 

 Further Acts. Designate other individuals to request advances, pay fees and costs and execute
other documents or agreements (including documents or agreement that waive Borrowers right to a jury trial) they believe to be necessary to effectuate such resolutions. 
 RESOLVED FURTHER, that all acts authorized by the above resolutions and any prior acts relating thereto are ratified. 
 5. The persons listed above are Borrower’s officers or employees with their titles and signatures shown next to their names. 
  

			
	By:	 	 
	Name:	 	 
	Title:	 	 

 *** If the Secretary, Assistant Secretary or other certifying officer executing above is
designated by the resolutions set forth in paragraph 4 as one of the authorized signing officers, this Certificate must also be signed by a second authorized officer or director of Borrower. 
  

	
	 I, the __________________________ of Borrower, hereby certify as to paragraphs 1 through 5 above, as of the date

	 [print title]

	set forth above.

  

			
	By:	 	 
	Name:	 	 
	Title:

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