Document:

EX-10.13

 Exhibit 10.13 

NANOSTRING TECHNOLOGIES, INC. 

WAYNE BURNS EMPLOYMENT AGREEMENT 

This Agreement is entered into as of June 8, 2009 (this “Agreement”) by and between NanoString Technologies, Inc., a
Delaware corporation (the “Company”), and Wayne Burns (“Executive”). 
 1. Position. 

(a) Title. Executive will serve as the Chief Financial Officer of the Company and, until the Company hires a Chief Executive Officer,
acting Chief Executive Officer of the Company. Executive will render such business and professional services in the performance of his duties, consistent with Executive’s position within the Company, as shall reasonably be assigned to him by
the Company’s Board of Directors (the “Board”). The period of Executive’s employment under this Agreement is referred to herein as the “Employment Term.” 

(b) Obligations. Executive agrees to the best of his ability and experience that he will at all times loyally and conscientiously
perform all of the duties and obligations required of and from him pursuant to the express and implicit terms hereof, and to the reasonable satisfaction of the Company. During the Employment Term, Executive further agrees that he will devote all of
his business time and attention to the business of the Company; the Company will be entitled to all of the benefits and profits arising from or incident to all such work services and advice; he will not render commercial or professional services of
any nature to any person or organization, whether or not for compensation, including but not limited to sitting on the Board of Directors of any for-profit corporation without the prior written consent of the Board; and he will not directly or
indirectly engage or participate in any business that is competitive in any manner with the business of the Company. Nothing in this Agreement will prevent Executive from accepting speaking or presentation engagements in exchange for honoraria or
from serving on boards of charitable organizations, or from owning no more than one percent (1%) of the outstanding equity securities of a corporation whose stock is listed on a national stock exchange. 

2. At-Will Employment. The parties agree that Executive’s employment with the Company is “at-will” employment and may be
terminated at any time with or without cause or notice. Executive understands and agrees that neither his job performance nor promotions, commendations, bonuses or the like from the Company give rise to or in any way serve as the basis for
modification, amendment, or extension, by implication or otherwise, of his employment with the Company. 
 3. Compensation. 

(a) Base Salary. During the Employment Term, the Company will pay Executive as compensation for his services a base salary at the
annualized rate of two hundred fifty thousand dollars ($250,000) (the “Base Salary”). The Base Salary will be paid periodically in accordance with the Company’s normal payroll practices and be subject to the usual, required
withholding, and shall be subject to annual review by the Board for any appropriate adjustment. 

 (b) Chief Executive Officer Bonus. In addition to the Base Salary, if the Company hires a
Chief Executive Officer during the Employment Term, the Company shall pay Executive a bonus equal to one (1) month of salary at the Base Salary rate, less applicable withholding (the “CEO Bonus”). The CEO Bonus shall be paid on
the first regularly scheduled payroll date following the date of such hiring and shall only be payable with respect to the first Chief Executive Officer hired after the date of this Agreement and not successor Chief Executive Officers, if any. 

(c) Bonus. Executive shall be entitled to receive an annual, performance-based, cash bonus of up to 25% of Executive’s Base
Salary for each calendar year, which bonus shall be awarded in the Board’s sole discretion, shall be based on Executive’s performance in the prior calendar year against metrics established for such year by the Company, and shall be paid by
no later than March 15 following the calendar year to which the bonus corresponds. If Executive is terminated by or leaves the Company prior to the end of a given calendar year, then the Company shall have no obligation to pay a bonus to
Executive for such year. 
 (d) Equity grant. At the first Board meeting following the execution of this Agreement and the Company
having received an independent valuation of the Company’s Common Stock in accordance with the provisions of Section 409A of the Internal Revenue Code, the Company shall award Executive an incentive stock option exercisable for a total of
one million two hundred fifty thousand (1,250,000) shares of common stock of the Company (the “Stock Option”), with an exercise price that is at least equal to the fair market value of the Company’s Common Stock on the
date of grant, a vesting commencement date that is the same as the date on which this agreement is entered into and on such terms and conditions as may be established by the Board in its reasonable discretion pursuant to the Company’s 2004
Stock Option Plan (the “Plan”). In the event that there is a Change in Control (as such term is defined in the Plan), and the Executive is terminated from employment without Cause (as defined below) or resigns for a Good Reason (as
defined below) on or within twelve months after the effective date of such Change in Control, then one hundred percent (100%) of the unvested portion of the Stock Option shall vest and become exercisable at the time of his termination from
employment. Executive shall be required to execute the Company’s standard form of stock option agreement. For the avoidance of doubt, with respect to the Executive’s prior grant of incentive stock options exercisable for a total of seven
hundred fifty thousand shares of common stock of the Company granted on May 25, 2007 (the “Prior Grant”), one hundred percent (100%) of the shares subject to the Prior Grant shall immediately vest and become exercisable
upon a Change of Control in accordance with the terms of the Prior Grant, whether or not Executive is terminated in connection with such Change of Control. 

4. Employee Benefits. During the Employment Term, Executive will be entitled to participate in the employee benefit plans currently and
hereafter maintained by the Company of general applicability to other senior executives of the Company, including, without limitation, the Company’s medical plans. The Company reserves the right to cancel or change the benefit plans and
programs it offers to its employees at any time. Executive shall also be entitled to take paid vacation consistent with the Company’s vacation policy approved by the Board. 

  
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 5. Severance Benefits. 

(a) Involuntary Termination. If Executive’s employment with the Company terminates as a result of an Involuntary Termination (as
defined below), and Executive signs and does not revoke a standard release of claims with the Company by no later than sixty (60) days after the date of termination, then, subject to Executive’s compliance with Section 8, Executive
shall receive severance pay (less applicable withholding taxes) at a rate equal to his Base Salary rate, as then in effect, for a period of six (6) months from the date such release of claims becomes effective (such payments shall be paid
periodically in accordance with the Company’s normal payroll policies). 
 (b) Voluntary Termination; Termination for Cause. If
Executive’s employment with the Company is terminated voluntarily by Executive or for Cause by the Company, then (i) all vesting of any unvested stock options or shares of restricted stock held by Executive as of the date of
Executive’s termination of employment will terminate immediately, (ii) all payments of compensation by the Company to Executive hereunder will terminate immediately (except as to amounts already earned) and (iii) Executive will only
be eligible for severance benefits in accordance with the Company’s established policies as then in effect. 
 (c) Termination by
Reason of Death or Disability. If Executive’s employment with the Company terminates as a result of Executive’s death or Disability (as defined in Section 6 below), Executive or Executive’s estate or representative will
receive all salary accrued (plus any other amounts payable as determined by the Board in its sole discretion) as of the date of Executive’s death or Disability and any other benefits payable under the Company’s then existing benefit plans
and policies in accordance with such plans and policies in effect on the date of death or Disability and in accordance with applicable law, Such payments shall be made by the Company periodically in accordance with the Company’s normal payroll
policies with respect to each element of such payments. 
 6. Definitions. 

(a) Cause. For purposes of this Agreement, “Cause” is defined as (i) a violation of a material written Company
policy that is communicated by the Board to Executive and that continues uncured for thirty (30) days, (ii) an act of dishonesty made by Executive in connection with Executive’s responsibilities as an employee,
(iii) Executive’s conviction of, or plea of nolo contendere to, a felony, (iv) Executive’s gross misconduct, (v) the failure or refusal of Executive to follow the lawful and proper directives of the Board that are
within the scope of the Executive’s duties set forth in Section 1 above and that is not corrected within thirty (30) days after written notice from the Board to Executive identifying such failure or refusal or
(vi) Executive’s material breach of the PIIA (as defined below) or Section 8(b) hereof. 

  
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 (b) Disability. For purposes of this Agreement, “Disability” shall mean
that Executive has been unable to perform his duties hereunder as the result of his incapacity due to physical or mental illness, and such inability, which continues for at least 120 consecutive calendar days or 150 calendar days during any
consecutive twelve-month period, is determined to be total and permanent by a physician selected by the Company and its insurers and acceptable to Executive or to Executive’s legal representative (with such agreement on acceptability not to be
unreasonably withheld). 
 (c) Good Reason. For purposes of this Agreement, “Good Reason” shall mean if
(A) there is (1) a material, adverse and permanent change in Executive’s position as set forth in Section 1(a) of this Agreement causing such position to be of materially reduced stature or responsibility (other than changes
related to Executive’s termination as the Chief Executive Officer), (2) a reduction of more than five percent (5%) in Executive’s Base Salary then in effect (other than any such reduction applicable to officers of the Company
generally), (3) a material reduction by the Company in the kind or level of employee benefits (other than Base Salary) to which Executive is entitled immediately prior to such reduction with the result that Executive’s overall benefits
package (other than Base Salary) is substantially reduced (other than any such reduction applicable to officers of the Company generally), (4) any material breach by the Company of any material provision of this Agreement which continues
uncured for thirty (30) days following notice by Executive thereof, or (5) a refusal by Executive, following a request by the Company, to relocate to a facility or location more than forty (40) miles from the Company’s current
location, and (B) Executive provides notice to the Company within thirty (30) days after the initial occurrence of the condition or event described above, the Company fails to cure or remedy any such condition or event within the
thirty (30) day period following its receipt of the notice, and Executive thereafter elects to terminate his employment voluntarily within thirty (30) days after the expiration of the period for correcting such condition or event;
provided, however, that none of the foregoing shall constitute Good Reason to the extent that Executive has agreed in writing to such material change, reduction, breach or refusal, and provided further that any change in Executive’s job
function or responsibilities in order to accommodate a disability under the Americans with Disabilities Act, the Family Medical Leave Act or any analogous statute or law shall not constitute a basis for Executive to involuntarily terminate his
employment hereunder. 
 (d) Involuntary Termination. For purposes of this Agreement, an “Involuntary Termination”
shall be deemed to occur if: (i) Executive’s employment with the Company is terminated by the Company for any reason other than Cause (and for a reason other than Executive’s death or Disability); or (ii) Executive terminates his
employment with the Company for Good Reason. 
 7. Proprietary Information and Inventions Agreement. Executive acknowledges that he
is and will continue to be bound by the terms and conditions of the Proprietary Information and Inventions Agreement (the “PIIA”), a copy of which is attached hereto as Exhibit A. 

  
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 8. Conditional Nature of Severance Payments. 

(a) Non-Solicitation; Non-Competition. Executive agrees and acknowledges that Executive’s right to receive the severance benefits
set forth in Section 5 (to the extent Executive is otherwise entitled to such benefits) shall be conditioned upon Executive’s continued compliance with Section 8 (Non-Solicitation) and Section 9 (Non-Competition) of the PIIA and
Section 8(b) of this Agreement. Upon any breach of this section, all severance benefits pursuant to this Agreement shall immediately cease including, without limitation, Executive’s right to exercise any stock options on a date that is
more than ninety (90) days after the date that Executive’s employment was terminated. 
 (b) Non-Disparagement. During and
after the Employment Term, Executive agrees to refrain from any defamation, libel or slander of the Company and its officers, directors, employees, agents, investors, stockholders, administrators, affiliates, divisions, subsidiaries, predecessor and
successor corporations, and assigns, and any tortious interference with the contracts, relationships and prospective economic advantage of any of the foregoing persons and entities. 

(c) Understanding of Covenants. Executive represents that he (i) is familiar with the covenants set forth in Section 8 and
Section 9 of the PIIA, and (ii) is fully aware of his obligations hereunder, including, without limitation, the reasonableness of the length of time, scope and geographic coverage of such covenants. 

9. Confidentiality of Terms. Executive agrees to follow the Company’s strict policy that employees must not disclose, either
directly or indirectly, any information, including any of the terms of this Agreement to any person, including other employees of the Company; provided, however, that Executive may discuss such terms with members of Executive’s
immediate family and any legal, tax or accounting specialists who provide Executive with individual legal, tax or accounting advice. 
 10.
Assignment. This Agreement will be binding upon and inure to the benefit of (a) the heirs, executors and legal representatives of Executive upon Executive’s death and (b) any successor of the Company. Any such successor of the
Company will be deemed substituted for the Company under the terms of this Agreement for all purposes. For this purpose, “successor” means any person, firm, corporation or other business entity which at any time, whether by purchase,
merger or otherwise, directly or indirectly acquires all or substantially all of the assets or business of the Company. None of the rights of Executive to receive any form of compensation payable pursuant to this Agreement may be assigned or
transferred except by will or the laws of descent and distribution. Any other attempted assignment, transfer, conveyance or other disposition of Executive’s right to compensation or other benefits will be null and void. 

  
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 11. Notices. All notices, requests, demands and other communications called for hereunder
shall be in writing and shall be deemed given (a) on the date of delivery if delivered personally, (b) one (1) day after being sent by a well established commercial overnight service, or (c) four (4) days after being mailed
by registered or certified mail, return receipt requested, prepaid and addressed to the parties or their successors at the following addresses, or at such other addresses as the parties may later designate in writing: 

If to the Company: 
 NanoString
Technologies, Inc. 
 530 Fairview Ave. N., Suite 2000 

Seattle, WA 98109 
 Attn: CEO 

If to Executive: 
 to the last
residential address known by the Company. 
 12. Severability. In the event that any provision hereof becomes or is declared by a
court of competent jurisdiction to be illegal, unenforceable or void, this Agreement will continue in full force and effect without said provision. 

13. Application of 409A. Notwithstanding anything to the contrary set forth herein, any payments and benefits provided under this
Agreement that constitute “deferred compensation” within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) and the regulations and other guidance thereunder and any state law of
similar effect (collectively, the “Section 409A”) shall not commence in connection with Executive’s termination of employment unless and until Executive has also incurred a “separation from service” (as such term
is defined in Treasury Regulation Section 1.409A-1(h) (the “Separation From Service”), unless the Company reasonably determines that such amounts may be provided to Executive without causing Executive to incur the
additional 20% tax under Section 409A. 
 It is intended that each installment of severance pay provided for in this Agreement is a
separate “payment” for purposes of Treasury Regulation Section 1.409A-2(b)(2)(i). For the avoidance of doubt, it is intended that severance payments set forth in this Agreement satisfy, to the greatest extent possible, the exceptions
from the application of Section 409A provided under Treasury Regulation Sections 1.409A-1(b)(4), 1.409A-1(b)(5), and 1.409A-1(b)(9). 

If the Company (or, if applicable, the successor entity thereto) determines that any payments or benefits constitute “deferred
compensation” under Section 409A and Executive is, on the termination of service, a “specified employee” of the Company or any successor entity thereto, as such term is defined in Section 409A(a)(2)(B)(i) of the Code, then,
solely to the extent necessary to avoid the incurrence of the adverse personal tax consequences under Section 409A, the timing of the payments and benefits shall be delayed until the earlier to occur of: (a) the date that is six months and
one day after Executive’s Separation From Service, or (b) the date of Executive’s death (such applicable date, the “Specified Employee Initial Payment Date”). On the Specified Employee Initial Payment Date, the Company (or
the successor entity thereto, as applicable) shall (i) pay to Executive a lump sum amount equal to the sum of the payments and benefits that Executive would otherwise have received through the Specified Employee Initial Payment Date if the
commencement of the payment of such amounts had not been so delayed pursuant to this Section and (ii) commence paying the balance of the payments and benefits in accordance with the applicable payment schedules set forth in this Agreement.

  
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 14. Arbitration. 

(a) General. In consideration of Executive’s service to the Company, his promise to arbitrate all employment related disputes and
Executive’s receipt of the compensation, pay raises and other benefits paid to Executive by the Company, at present and in the future, Executive agrees that any and all controversies, claims, or disputes with anyone (including the Company and
any employee, officer, director, stockholder or benefit plan of the Company in their capacity as such or otherwise) arising out of, relating to, or resulting from Executive’s service to the Company under this Agreement or otherwise or the
termination of Executive’s service with the Company, including any breach of this Agreement, shall be subject to binding arbitration under the Arbitration Rules set forth in the Revised Code of Washington Chapter 7.04 (the
“Rules”) and pursuant to Washington law. Disputes which Executive agrees to arbitrate, and thereby agrees to waive any right to a trial by jury, include any statutory claims under state or federal law, including, but not limited to,
claims under Title VII of the Civil Rights Act of 1964, the Americans with Disabilities Act of 1990, the Age Discrimination in Employment Act of 1967, the Older Workers Benefit Protection Act, claims of harassment, discrimination or wrongful
termination. Executive further understands that this Agreement to arbitrate also applies to any disputes that the Company may have with Executive. 

(b) Procedure. Executive agrees that any arbitration will be administered by the American Arbitration Association
(“AAA”) and that a neutral arbitrator will be selected in a manner consistent with its National Rules for the Resolution of Employment Disputes. The arbitration proceedings will allow for discovery according to the rules set forth
in the National Rules for the Resolution of Employment Disputes or the Washington Code of Civil Procedure. Executive agrees that the arbitrator shall have the power to decide any motions brought by any party to the arbitration, including
motions for summary judgment and/or adjudication and motions to dismiss and demurrers, prior to any arbitration hearing. Executive agrees that the arbitrator shall issue a written decision on the merits with findings of fact and conclusions of law.
Executive also agrees that the arbitrator shall have the power to award any remedies, including attorneys’ fees and costs, available under applicable law. Executive understands the Company will pay for any administrative or hearing fees charged
by the arbitrator or AAA except that Executive shall pay the first $200.00 of any filing fees associated with any arbitration Executive initiates. Executive agrees that the arbitrator shall administer and conduct any arbitration in a manner
consistent with the Rules and that to the extent that the AAA’s National Rules for the Resolution of Employment Disputes conflict with the Rules, the Rules shall take precedence. 

(c) Remedy. Except as provided by the Rules, arbitration shall be the sole, exclusive and final remedy for any dispute between
Executive and the Company. Accordingly, except as provided for by the Rules, neither Executive nor the Company will be permitted to pursue court action regarding claims that are subject to arbitration. Notwithstanding, the arbitrator will not have
the authority to disregard or refuse to enforce any lawful Company policy, and the arbitrator shall not order or require the Company to adopt a policy not otherwise required by law which the Company has not adopted. 

  
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 (d) Availability of Injunctive Relief. In addition to the right under the Rules to
petition the court for provisional relief, Executive agrees that any party may also petition the court for injunctive relief where either party alleges or claims a violation of this Agreement or the PIIA or any other agreement regarding trade
secrets, confidential information, non-competition, non-solicitation or non-disparagement. In the event either party seeks injunctive relief, the prevailing party shall be entitled to recover reasonable costs and attorneys’ fees. 

(e) Administrative Relief. Executive understands that this Agreement does not prohibit Executive from pursuing an administrative claim
with a local, state or federal administrative body such as the Washington State Human Rights Commission, Equal Employment Opportunity Commission or the workers’ compensation board. This Agreement does, however, preclude Executive from pursuing
court action regarding any such claim. 
 (f) Voluntary Nature of Agreement. Executive acknowledges and agrees that Executive is
executing this Agreement voluntarily and without any duress or undue influence by the Company or any other person. Executive further acknowledges and agrees that Executive has carefully read this Agreement and that Executive has asked any questions
needed for Executive to understand the terms, consequences and binding effect of this Agreement and fully understand it, including that Executive is waiving Executive’s right to a jury trial. Finally, Executive agrees that Executive has been
provided an opportunity to seek the advice of an attorney of Executive’s choice before signing this Agreement. 
 15.
Integration. This Agreement, any stock option and restricted stock agreements between the Company and Executive and the PIIA represent the entire agreement and understanding between the parties as to the subject matter herein and supersede
all prior or contemporaneous agreements whether written or oral. No waiver, alteration, or modification of any of the provisions of this Agreement will be binding unless in writing and signed by duly authorized representatives of the parties hereto.

 16. Tax Withholding. All payments made pursuant to this Agreement will be subject to withholding of applicable taxes. 

17. Governing Law. This Agreement will be governed by the laws of the State of Washington, without giving effect to principles of
conflict of laws. 

  
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 IN WITNESS WHEREOF, the parties have executed this Agreement as of the day and year first above
written. 
  

			
	COMPANY:
	
	NANOSTRING TECHNOLOGIES, INC.
		
	By:		 /s/ Charles Waite

			
		
	Print Name:		 CHARLES WAITE

			
		
	Title:		 CFO

  

			
	EXECUTIVE:		
	
	 /s/ Wayne Burns

	Wayne Burns

 EXHIBIT A 

PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 

 NANOSTRING TECHNOLOGIES, INC. 

PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 

(WASHINGTON EMPLOYEES) 
 In
consideration for my becoming employed (or my employment being continued), or retained as a consultant (or my consulting relationship being continued), by NanoString Technologies, Inc. or any of its current or future subsidiaries, affiliates,
successors or assigns (collectively, the “Company”), the Company and I hereby agree as follows: 
 1. Duties.
I will perform for the Company such duties as may be designated by the Company from time to time. During my period of employment or consulting relationship with the Company, I will devote my best efforts to the interests of the Company and will not
engage in other employment or in any activities detrimental to the best interests of the Company without the prior written consent of the Company. 

2. Confidentiality Obligation. I understand and agree that all Proprietary Information (as defined below) shall be the sole
property of the Company and its assigns, including all trade secrets, patents, copyrights and other rights in connection therewith. I hereby assign to the Company any rights I may acquire in such Proprietary Information. I will hold in confidence
and not directly or indirectly) .use or disclose, both during my employment by or consulting relationship with the Company and after its termination (irrespective of the reason for such termination), any Proprietary Information I obtain or create
during the period of my employment or consulting relationship, whether or not during working hours, except to the extent authorized by the Company, until such Proprietary Information becomes generally known. I agree not to make copies of such
Proprietary Information except as authorized by the Company. Upon termination of my employment or consulting relationship or upon an earlier request of the Company, I will return or deliver to the Company all tangible forms of such Proprietary
Information in my possession or control, including but not limited to drawings, specifications, documents, records, devices, models or any other material and copies or reproductions thereof. 

3. Ownership of Physical Property. All document, apparatus, equipment and other physical property in any form, whether or
not pertaining to Proprietary Information, furnished to me by the Company or produced by me or others in connection with my employment or consulting relationship shall be and remain the sole property of the Company. I shall return to the Company all
such documents, materials and property as and when requested by the Company, except only (i) my personal copies of records relating to my compensation; (ii) if applicable, my personal copies of any materials evidencing shares of the
Company’s capital stock purchased by me and/or options to purchase shares of the Company’s capital stock granted to me; (iii) my copy of this Agreement and (iv) my personal property and personal documents I bring with me to the
Company and any personal correspondence and personal materials that I accumulate and keep at my office during my employment (my “Personal Documents”). Even if the Company does not so request, I shall return all such documents,
materials and property upon termination of my employment or consulting relationship, and, except for my Personal Documents, I will not take with me any such documents, material or property or any reproduction thereof upon such termination.

 4. Assignment of Inventions. 

(a) Without further compensation, I hereby agree promptly to disclose to the Company, all Inventions (as defined below) which I may solely or
jointly develop or reduce to practice during the period of my employment or consulting relationship with the Company which (i) pertain to any line of business activity of the Company, (ii) are aided by the use of time, material or
facilities of the Company, whether or not during working hours or (iii) relate to any of my work during the period of my employment or consulting relationship with the Company, whether or not during normal working hours (“Company
Inventions”). During the term of my employment or consultancy, all Company Inventions that I conceive, reduce to practice, develop or have developed (in whole or in part, either alone or jointly with others) shall be the sole property of
the Company and its assigns to the maximum extent permitted by law (and to the fullest extent permitted by law shall be deemed “works made for hire”), and the Company and its assigns shall be the sole owner of all patents, copyrights,
trademarks, trade secrets and other rights in connection therewith. I hereby assign to the Company any rights that I may have or acquire in such Company Inventions. 

(b) I attach hereto as Exhibit A a complete list of all Inventions, if any, made by me prior to my employment or consulting relationship
with the Company that are relevant to the Company’s business, and I represent and warrant that such list is complete. If no such list is attached to this Agreement, I represent that I have no such Inventions at the time of signing this
Agreement. If in the course of my employment or consultancy (as the case may be) with the Company, I use or incorporate into a product or process an Invention not covered by Section 4(a) of this Agreement in which I have an interest, the
Company is hereby granted a nonexclusive, fully paid-up, royalty-free, perpetual, worldwide license of my interest to use and sublicense such Invention without restriction of any kind. 

NOTICE REQUIRED BY REVISED CODE OF WASHINGTON 49.44.140: 

Any assignment of Inventions required by this Agreement does not apply to an Invention for which no equipment, supplies, facility or trade
secret information of the Company was used and which was developed entirely on the employee’s own time, unless (a) the Invention relates (i) directly to the business of the Company or (ii) to the Company’s actual or
demonstrably anticipated research or development or (b) the Invention results from any work performed by the employee for the Company. 

5. Further Assistance: Power of Attorney. I agree to perform, during and after my employment or consulting relationship, all
acts deemed necessary or desirable by the Company to permit and assist it, at its expense, in obtaining and enforcing the full benefits, enjoyment, rights and title throughout the world in the Inventions assigned to the Company as set forth in
Section 4 above. Such acts may include, but are not limited to, execution of documents and assistance or cooperation in legal proceedings. I hereby irrevocably designate the Company and its duly authorized officers and agents as my agent and
attorney-in fact, to execute and file on my behalf any such applications 

  
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and to do all other lawful acts to further the prosecution and issuance of patents, copyright and mask work registrations related to such Inventions. This power of attorney shall not be affected
by my subsequent incapacity. 
 6. Inventions. As used in this Agreement, the term “Inventions” means discoveries,
developments, concepts, designs, ideas, know-how, improvements, inventions, trade secrets and/or original works of authorship, whether or not patentable, copyrightable or otherwise legally protectable. This includes, but is not limited to, any new
product, machine, article of manufacture, biological material, method, procedure, process, technique, use, equipment, device, apparatus, system, compound, formulation, composition of matter, design or configuration of any kind, or any improvement
thereon. 
 7. Proprietary Information. As used in this Agreement, the term “Proprietary Information” means
information or physical material not generally known or available outside the Company or information or physical material entrusted to the Company by third parties. This includes, but is not limited to, Inventions, confidential knowledge,
copyrights, product ideas, techniques, processes, formulas, object codes, biological materials, mask works and/or any other information of any type relating to documentation, laboratory notebooks, data, schematics, algorithms, flow charts,
mechanisms, research, manufacture, improvements, assembly, installation, marketing, forecasts, sales, pricing, customers, the salaries, duties, qualifications, performance levels and terms of compensation of other employees, and/or cost or other
financial data concerning any of the foregoing or the Company and its operations. Proprietary Information may be contained in material such as drawings, samples, procedures, specifications, reports, studies, customer or supplier lists, budgets, cost
or price lists, compilations or computer programs, or may be in the nature of unwritten knowledge or know-how. 
 8. Solicitation of
Employees. Consultants and Other Parties. During the term of my employment or consulting relationship with the Company, and for a period of one year following the termination of my relationship with the Company for any reason, I will not
directly or indirectly solicit, induce, recruit or encourage any of the Company’s employees or consultants to terminate their relationship with the Company, or attempt any of the foregoing, either for myself or any other person or entity.
Further, at any time following termination of my relationship with the Company for any reason, I shall not use any Proprietary Information of the Company to attempt to negatively influence any of the Company’s clients or customers from
purchasing any of the Company’s products or services, or solicit any licensor to or customer of the Company or licensee of the Company’s products, that are known to me, with respect to any business, products or services that are
competitive to the products or services offered by the Company or under development as of the date of termination of my relationship with the Company. 

9. Noncompetition. During the term of my employment or consulting relationship with the Company and for one year following the
termination of my relationship with the Company for any reason, I will not, without the Company’s prior written consent, directly or indirectly work on any products or services that are competitive with products or services (a) being
commercially developed or exploited by the Company during my employment or consultancy and (b) on which I worked or about which I learned Proprietary Information during my employment or consultancy with the Company. 

  
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 10. No Conflicts. I represent that my performance of all the terms of this
Agreement as an employee of or consultant to the Company does not and will not breach any agreement to keep in confidence proprietary information, knowledge or data acquired by me in confidence or in trust prior to my becoming an employee or
consultant of the Company, and I will not disclose to the Company, or induce the Company to use, any confidential or proprietary information or material belonging to any previous employer or others. I agree not to enter into any written or oral
agreement that conflicts with the provisions of this Agreement. 
 11. No Interference. I certify that, to the best of my
information and belief, I am not a party to any other agreement which will interfere with my full compliance with this Agreement. 
 12.
Effects of Agreement. This Agreement (a) shall survive for a period of five years beyond the termination of my employment by or consulting relationship with the Company, (b) inures to the benefit of successors and assigns of
the Company and (c) is binding upon my heirs and legal representatives. 
 13. At-Will Relationship. I understand and
acknowledge that my employment or consulting relationship with the Company is and shall continue to be at-will, as defined under applicable law, meaning that either I or the Company may terminate the relationship at any time for any reason or no
reason, without further obligation or liability. 
 14. Injunctive Relief. I acknowledge that violation of this Agreement by
me may cause irreparable injury to the Company, and I agree that the Company will be entitled to seek extraordinary relief in court, including, but not limited to, temporary restraining orders, preliminary injunctions and permanent injunctions
without the necessity of posting a bond or other security and without prejudice to any other rights and remedies that the Company may have for a breach of this Agreement. 

15. Miscellaneous. This Agreement supersedes any oral, written or other communications or agreements concerning the subject
matter of this Agreement, and may be amended or waived only by a written instrument signed by me and the Chief Executive Officer of the Company. This Agreement shall be governed by the laws of the State of Washington applicable to contracts entered
into and performed entirely within the State of Washington, without giving effect to principles of conflict of laws. If any provision of this Agreement is held to be unenforceable under applicable law, then such provision shall be excluded from this
Agreement only to the extent unenforceable, and the remainder of such provision and of this Agreement shall be enforceable in accordance with its terms. 

16. Acknowledgement. I certify and acknowledge that I have carefully read all of the provisions of this Agreement and that I
understand and will fully and faithfully comply with such provisions. 

  
 -4- 

 [Signature Page Follows] 

  
 -5- 

 The undersigned have executed this Proprietary information and Inventions Agreement as of the
date set forth below. 
  

					
	NANOSTRING TECHNOLOGIES, INC.				Wayne Burns, an Individual
			
	 /s/ H. Perry Fell
				 /s/ Wayne Burns

	Signature				Signature
	H. Perry Fell, President & CEO				
			
	Dated: 4/11/07				Date: April 10, 2007

 SIGNATURE PAGE TO NANOSTRING TECHNOLOGIES, INC. 

PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 

 Exhibit A 

Nanostring Technologies, Inc. 

201 Elliott Ave West, Suite 300 

Seattle, WA 98119 
 Ladies and
Gentlemen: 
 1. The following is a complete list of all Inventions relevant to the subject matter of my employment by the Company that have
been made or conceived or first reduced to practice by me, alone or jointly with others or which has become known to me prior to my employment by the Company. I represent that such list is complete. 

NONE 
 2. I propose to bring to
my employment or consultancy the following materials and documents of a former employer: 

x  No materials or documents. 

 ̈  See below: 

 

			
	By:		 /s/ Wayne Burns

			 Wayne Burns

			[Please Print Name]

 NANOSTRING TECHNOLOGIES, INC. 

AMENDMENT TO WAYNE BURNS EMPLOYMENT AGREEMENT 

This Amendment to Wayne Burns Employment Agreement (this “Amendment”) dated as of February 5, 2010 is by and between
NanoString Technologies, Inc., a Delaware corporation (the “Company”) and Wayne Burns (“Executive”). This Amendment amends the NanoString Technologies, Inc. Wayne Burns Employment Agreement dated June 8, 2009
(the “Original Agreement”) by and between the Company and Executive. All capitalized terms used but not defined in this Amendment shall have the meanings assigned to such terms in the Original Agreement. 

RECITALS 
 WHEREAS, the
Company and Executive desire to amend the Original Agreement to, among other things, (i) increase the CEO Bonus (as defined in the Original Agreement) payable to Executive pursuant to Section 3(b) of the Original Agreement from one
(1) month of salary to two (2) months of salary and (ii) increase the severance benefits payable to Executive following Executive’s Involuntary Termination (as defined in the Original Agreement) from six (6) months Base
Salary (as defined in the Original Agreement) then in effect to one (1) year Base Salary then in effect. 
 NOW THEREFORE, in
consideration of the foregoing promises and certain other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

AGREEMENT 
 1.
Amendment to Section 3(b). Section 3(b) of the Original Agreement is hereby amended and restated in its entirety to read as follows: 

“Chief Executive Officer Bonus. In addition to the Base Salary, if the Company hires a Chief Executive Officer during the Employment Term,
the Company shall pay Executive a bonus equal to two (2) months salary at the Base Salary rate, less applicable withholding (the “CEO Bonus”). The CEO Bonus shall be paid on the first regularly scheduled payroll date following
the date of such hiring and shall only be payable with respect to the first Chief Executive Officer hired after the date of this Agreement and not successor Chief Executive Officers, if any.” 

2. Amendment to Section 5(a). Section 5(a) of the Original Agreement is hereby amended and restated in its entirety to read
as follows: 
 “Involuntary Termination. If Executive’s employment with the Company terminates as a result of an Involuntary
Termination (as defined below), and Executive signs and does not 

 
revoke a standard release of claims with the Company by no later than sixty (60) days after the date of termination, then, subject to Executive’s compliance with Section 8,
Executive shall receive severance pay (less applicable withholding taxes) at a rate equal to his Base Salary rate, as then in effect, for a period of one (1) year from the date such release of claims becomes effective (such payments shall be
paid periodically in accordance with the Company’s normal payroll policies).” 
 3. Effect of Amendment. Except as set
forth in this Amendment, the provisions of the Original Agreement shall remain unchanged and shall continue in full force and effect. 
 4.
Entire Agreement. This Amendment and the Original Agreement constitute the full and entire understanding and agreement between the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the
subject matter hereof existing between the parties are expressly canceled. 
 5. Counterparts; Facsimile. This Amendment may be
executed and delivered by facsimile signature and in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

6. Governing Law. This Amendment and any controversy arising out of or relating to this Amendment shall be governed by and construed in
accordance with the internal laws of the State of Washington without regard to conflict of law principles that would result in the application of any law other than the law of the State of Washington. 

IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first written above. 

 

			
	COMPANY:
	
	NANOSTRING TECHNOLOGIES, INC.
		
	By:		 /s/ Nick Galakatos

	Name:		Nick Galakatos
	Title:		Director

  

			
	EXECUTIVE:
	
	WAYNE BURNS
	
	 /s/ Wayne Burns

  
 -2- 

 NANOSTRING TECHNOLOGIES, INC. 

AMENDMENT TO EMPLOYMENT AGREEMENT 

This amendment (the “Amendment”) is made by and between Wayne Burns (“Executive”) and NanoString
Technologies, Inc. (the “Company,” and together with Executive, the “Parties”) on the dates set forth below. 

WHEREAS, the Parties entered into an employment agreement effective June 8, 2009 (the “Employment Agreement”);

 WHEREAS, the Company and Executive desire to amend certain provisions of the Employment Agreement in order to clarify the timing
of the severance payment, as set forth below, in accordance with Section VI.B.3 of Internal Revenue Service Notice 2010-6, as amended by Internal Revenue Service Notice 2010-80. 

NOW, THEREFORE, for good and valuable consideration, Executive and the Company agree that the Employment Agreement is hereby amended as
follows. 
 1. Section 409A. Section 13 of the Employment Agreement is hereby amended to insert the following paragraph immediately
following the first paragraph thereof: 
 “Any severance payments or benefits under this Agreement that would be
considered “deferred compensation” under Section 409A will be paid on, or, in the case of installments, will not commence until, the sixtieth (60th) day following Executive’s
Separation From Service, of, if later, such time is required by the final paragraph of this Section 13. Except as required by the final paragraph of this Section 13, any installment payments that would have been made to Executive during the 60 day
period immediately following Executive’s Separation From Service but for the preceding sentence will be paid to Executive on the sixtieth (60th) day following Executive’s Separation
from Service and the remaining payments shall be made as provided in this Agreement.” 
 2. Full Force and Effect. To the extent
not expressly amended hereby, the Agreement shall remain in full force and effect. 
 3. Entire Agreement. This Amendment and the
Agreement constitute the full and entire understanding and agreement between the Parties with regard to the subjects hereof and thereof. This Amendment may be amended at any time only by mutual written agreement of the Parties. 

4. Counterparts. This Amendment may be executed in counterparts, all of which together shall constitute one instrument, and each of
which may be executed by less than all of the parties to this Amendment. 

 5. Governing Law. This Amendment will be governed by the laws of the State of Washington
(with the exception of its conflict of laws provisions). 
 IN WITNESS WHEREOF, each of the Parties has executed this Amendment, in
the case of the Company by its duly authorized officer, on the dates set forth below. 
  

							
	NANOSTRING TECHNOLOGIES, INC.				Wayne Burns
			
	 /s/ Brad Gray
				 /s/ Wayne Burns

				
	By:		 Brad Gray
				
				
	Date:		 12/26/12
				 12/26/12

  
 -2-EX-10.14

 Exhibit 10.14 

EXECUTION VERSION 

LEASE 
 by and between 

BMR-530 FAIRVIEW AVENUE LLC, 

a Delaware limited liability company 

and 
 NANOSTRING TECHNOLOGIES,
INC., 
 a Delaware corporation 

 LEASE 

THIS LEASE (this “Lease”) is entered into as of this 19th day of October, 2007 (the “Execution Date”), by
and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
WHEREAS, Landlord owns certain real property (the “Property”) located at 530 Fairview Avenue in Seattle, Washington, and intends to construct a building located thereon (the “Building”) in which the Premises (as
defined below) shall be located; and 
 B. WHEREAS, Landlord wishes to lease to Tenant, and Tenant desires to lease from Landlord, certain
premises (the “Premises”) consisting of (a) the entire second floor of the Building and (b) storage rooms 107 and 109 of the Building (the “Storage Rooms”) pursuant to the terms and conditions of this
Lease, as detailed below. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Lease of
Premises. Effective on the Term Commencement Date, Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, the Premises, as shown on Exhibit A attached hereto for use by Tenant in accordance with the Permitted Use
(as defined below) and no other uses. The Premises comprise the entire second (2nd) floor of the Building. The Property and all landscaping, parking facilities and other improvements and appurtenances related thereto, including, without
limitation, the Building, are hereinafter collectively referred to as the “Project.” All portions of the Project that are for the non-exclusive use of tenants of the Building, including,
without limitation, driveways, sidewalks, parking areas, landscaped areas, service corridors, stairways, elevators, public restrooms and public lobbies, are hereinafter referred to as “Common Area.” 

Tenant and Cell Therapeutics, Inc. (“CTI”) are parties to that certain Sublease dated October 6, 2004, as amended, under
which Tenant subleases from CTI certain premises located at 201 Elliott Avenue West, Seattle, Washington (“Sublease Premises”). CTI leases the Sublease Premises from BMR-201 Elliot Avenue LLC
(“Master Landlord”). This Lease is contingent upon the simultaneous full execution by Tenant and Master Landlord of an agreement in the form of the attached Exhibit J. 

 2. Basic Lease Provisions. For convenience of the parties, certain basic provisions of
this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 

2.1 This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the
provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 

2.2 In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and
Tenant’s Pro Rata Share are both subject to adjustment as provided in this Lease. 
  

					
	 Definition or Provision
	  	Means the Following (As of the Term
Commencement Date)	 
		
	 Approximate Rentable Area of Premises (without the Expansion Premises)
	  	 	16,852 square feet	  
		
	 Approximate Rentable Area of Building
	  	 	95,849 square feet	  
		
	 Approximate Tenant’s Pro Rata Share of Building (without the Expansion Premises)
	  	 	17.60	% 

 2.3 Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square foot
of Rentable Area of the Premises, subject to adjustment under this Lease. Initial monthly and annual installments of Basic Annual Rent as of the Rent Commencement Date, subject to adjustment under this Lease: 

 

													
	 	  	Rentable Area	  	Per S.F. of
Rentable Area	  	Approximate
Total Annual	 	  	Approximate
Total Monthly	 
	 Premises (without the Expansion Premises)
	  	Approximately
16,852 square feet	  	$51.00 annually	  	$	859,452	  	  	$	71,621.00	  

 2.4 Estimated Delivery Date: June 1, 2008 

2.5 Term Commencement Date: The later to occur of (i) Substantial Completion (as defined below) of the Core and Shell Work and the Tenant
Improvements, or (ii) July 1, 2008 
 2.6 Term Expiration Date: Five (5) years after the Rent Commencement Date; provided,
however, Tenant shall have the option to extend this Lease as provided in Article 42 
 2.7 Rent Commencement Date: One hundred
eighty (180) days after the Term Commencement Date 

  
 -2- 

 2.8 Security Deposit: An amount equal to Basic Annual Rent for the first full month after the
Rent Commencement Date ($67,681.25), subject to increase in accordance with the terms hereof 
 2.9 Permitted Use: 

(a) Second Floor Portion of Premises: General office and laboratory use in conformity with Applicable Laws (as defined below) 

(b) Storage Rooms Portion of Premises: General storage use 
  

					
			2.10 Address for Rent Payment:		BMR-530 Fairview Avenue LLC
					17140 Bernardo Center Drive, Suite 222
					San Diego, California 92128

  

					
			2.11 Address for Notices to Landlord:		 BMR-530 Fairview Avenue LLC

17140 Bernardo Center Drive, Suite 222
 San Diego, California
92128
 Attn: General Counsel/Real Estate

 2.12 Address for Notices to Tenant: 
  

			
	Prior to the Term Commencement Date:		Nanostring Technologies, Inc.
			201 Elliot Avenue West
			Seattle, Washington
			Attn: CFO
		
	With a copy to:		Heller Ehrman
			701 Fifth Avenue
			Suite 6100
			Seattle, Washington
			Attn: Sonya Erikson
		
	After the Term Commencement Date		Nanostring Technologies, Inc.
			Suite 2000
			530 Fairview Avenue
			Seattle, WA
			Attn: CFO
		
	With a copy to:		Heller Ehrman
			701 Fifth Avenue
			Suite 6100
			Seattle, Washington
			Attn: Sonya Erikson

  
 -3- 

 2.13 The following Exhibits are attached hereto and incorporated herein by reference: 

 

			
	Exhibit A		Premises
	Exhibit B		Acknowledgement of Term Commencement Date and Term Expiration Date
	Exhibit C		[Intentionally Deleted]
	Exhibit D		Rules and Regulations
	Exhibit E		Form of Estoppel Certificate
	Exhibit F		[Intentionally Deleted]
	Exhibit G		Work Letter
	Exhibit H		Form of Letter of Credit
	Exhibit I		Form of Additional TI Allowance Acceptance Letter
	Exhibit J		Form of Holdover Side Letter
	Exhibit K		[Intentionally Deleted]
	Exhibit L		Warm Shell Costs

 3. Term. 

3.1 The actual term of this Lease (the “Term”) shall be that period from the actual Term Commencement Date (as defined in
Section 2.5 above) through the Term Expiration Date, subject to earlier termination of this Lease as provided herein. 
 4.
Core and Shell Work and Tenant Improvements. 
 4.1 Shell and Core Construction of Building. 

4.1.1 Commencement of Core and Shell Work. Landlord shall, at Landlord’s sole cost and expense (except that Tenant shall pay (as
a deduction against the TI Allowance) Tenant’s Pro Rata Share of the costs incurred by Landlord in performing, or causing to be performed, the work described on, or necessary to cause the Building to comply with the requirements set forth on,
or the depiction of the warm shell which is attached hereto as Exhibit L, including the costs of design, permitting and construction in connection therewith (such costs, the “Warm Shell Costs”)), cause Landlord’s
contractor, M.A. Mortenson or such replacement thereof as Landlord may make from time to time (“Core and Shell Contractor”), to diligently prosecute the construction of the core and shell of the Building to completion pursuant to
the Approved Core and Shell Plans (as defined in the Work Letter), subject only to Core and Shell Permitted Changes (as defined in the Work Letter attached hereto as Exhibit G), (all such construction, collectively, “Core and
Shell Work”). Core and Shell Work shall be performed in a workmanlike manner, and shall confoun with Applicable Laws. The commencement and completion of Core and Shell Work shall be subject to delays resulting from acts of Tenant or Force
Majeure. “Force Majeure” shall mean acts of God; acts of terrorism; adverse weather conditions; war; invasion; insurrection; acts of a public enemy; terrorism; riot; mob violence; civil commotion; sabotage; strikes, lockouts or
other labor disputes; inability to procure or general shortage of labor, materials, facilities, equipment or supplies on the open market; delay in transportation; laws, rules, regulations or orders of any

  
 -4- 

 
Governmental Authority; moratorium or other governmental action; inability to obtain permits or approvals, including, without limitation, city and public utility approvals; the acts or inaction
of the contractor and subcontractors, if any; or any other cause beyond the reasonable control of Landlord, financial ability excepted, whether similar or dissimilar to the foregoing. 

4.1.2 Completion of Construction. Core and Shell Work shall be deemed “Substantially Complete” or there shall be
“Substantial Completion” if Landlord has (a) completed all of the Core and Shell Work identified on the Approved Core and Shell Plans (subject only to such incomplete or defective work as will not materially or adversely impact
Tenant’s use of the Premises (collectively, the “Punchlist Items”)) and (b) received a temporary or other certificate of occupancy from the applicable municipal authority(ies) or a certificate of substantial completion
from the architect. Landlord and Tenant shall work together in the thirty (30) days following Landlord’s Substantial Completion of the Core and Shell Work to develop the list of Punchlist Items, which Landlord shall use good faith,
diligent efforts to complete diligently. Landlord shall endeavor in good faith to cause the Contractor to fix any defects in the Core and Shell Work. 

4.2 Tenant Improvements. Landlord shall cause the Core and Shell Contractor or another Contractor designated by Landlord and approved
by Tenant, such consent not to be unreasonably withheld or delayed (“TI Contractor”, and together with Core and Shell Contractor, “Contractor”) to commence and thereafter diligently prosecute the construction of the
tenant improvements in the Premises pursuant to the Work Letter (the “Tenant Improvements”); provided, however, that before performing the Tenant Improvements, Landlord shall prepare in good faith an estimated budget
for the construction of the Tenant Improvements and deliver such budget to Tenant for Tenant’s written approval prior the start of construction (the “Budget”). Landlord and Tenant shall work together cooperatively and in good
faith to achieve a mutually acceptable Budget. Landlord shall update the Budget for Tenant’s review and approval at reasonable intervals and shall notify Tenant in writing if the Budget is likely to be exceeded. If there is an indication that
the Budget is likely to be exceeded, Landlord and Tenant shall work together cooperatively, if required by Tenant, to modify the scope of the Tenant Improvements to bring the same in line with a budget reasonably acceptable to Tenant. The Tenant
Improvements shall be performed in a workmanlike manner and shall substantially conform with Applicable Laws and the Approved TI Plans (as defined in the Work Letter). Tenant shall pay all TI Costs, except that Landlord shall pay for TI Costs that
do not exceed the TI Allowance. The “TI Allowance” shall mean (a) One Hundred Twenty Five Dollars ($125.00) per rentable square foot of the Premises (the “Initial TI Allowance”), together with (b) the
Additional Allowance. The “TI Costs” shall mean all Tenant Core and Shell Costs (as defined in the Work Letter) and all costs and expenses of performing the TI Work, including without limitation the hard and soft costs of
(i) construction, (ii) the Construction Management Fee (as such term is defined in the Work Letter) and any Project or construction management fees paid by Tenant to an unaffiliated third party (such fees not to exceed three percent
(3%) of the TI Allowance), (iii) space planning, design, architect, engineering, data and phone cabling and other related services, (iv) costs and expenses for labor, material, equipment, data and phone cabling and fixtures
(including, without limitation, any of the Attached Property (as defined in Section 18.5), (v) building permits and other taxes, fees, charges and levies by governmental and quasi-governmental agencies for permits or for inspections of the
Tenant Improvements, and (vi) the 

  
 -5- 

 
Warm Shell Costs. In no event shall the TI Allowance be used for: (w) the purchase of any furniture, personal property or other non-building system
equipment, (x) costs resulting from a Tenant Delay, (y) costs resulting from any default by Tenant of its obligations under this Lease, or (z) costs that are recoverable or reasonably recoverable by Tenant from a third party (e.g.,
insurers, warrantors, or tortfeasors). In the event the estimated total TI Costs (as set forth in the Budget) exceed the TI Allowance, Tenant shall deposit with Landlord such overage (the “TI Allowance Excess”), within five
(5) business days of receiving the Budget (the “TI Deposit”). In the event Landlord determines the estimate of the TI Costs set forth in the Budget underestimates the amount of TI Costs so that the TI Deposit will not be
sufficient to cover the TI Allowance Excess, then Landlord shall communicate the same to Tenant and, if required by Tenant, the parties shall discuss revisions to the Budget and Tenant may make a TI Tenant Change Order Request to reduce TI Costs,
and unless the TI Costs are reduced to be within the Budget and previously paid TI Deposit, Tenant shall promptly pay the additional amount to Landlord, and such additional amount shall be added to the TI Deposit. If the sum of the TI Allowance plus
the TI Deposit is not sufficient to cover the TI Costs, Tenant shall reimburse Landlord the difference between (a) the TI Costs and (b) the sum of the TI Allowance and the TI Deposit. However, Landlord shall be solely responsible for any
costs related to the Tenant Improvements to the extent the same result from Landlord’s gross negligence, intentional misconduct or breach of Lease. Landlord and Tenant shall work together cooperatively at no cost or risk to Landlord to maximize
Tenant’s ability, to the extent reasonably possible, to obtain the benefit of any applicable research and development tax credits with respect to the Tenant Improvements. 

4.2.1 Architects, Contractors and Consultants. The architect, engineering consultants, design team, general contractor and
subcontractors responsible for the construction of the Tenant Improvements shall be selected by Landlord and approved by Tenant, which approval Tenant shall not unreasonably withhold, condition or delay. Landlord shall supervise all such entities
and endeavor in good faith to ensure that the same design and construct the Core and Shell Work and the Tenant Improvements in compliance with this Lease. 

4.2.2 Completion of Tenant Improvements. The Tenant Improvements for the Premises shall be deemed “Substantially
Complete” or there shall be “Substantial Completion” if Landlord has completed all of the respective Tenant Improvements identified on the Approved TI Plans (subject only to the Punchlist Items) for such Phase. Landlord and
Tenant shall work together in the thirty (30) days following Landlord’s Substantial Completion of the Tenant Improvements to develop the list of Punchlist Items, which Landlord shall use diligent, good faith efforts to complete diligently.
Notwithstanding anything to the contrary, Landlord shall be responsible, at its sole cost, to promptly correct any defects or violations of law with respect to the Tenant Improvements throughout the Term. 

4.2.3 Additional Allowance. Landlord shall, at Tenant’s request, provide an additional tenant improvement allowance not to exceed
Fifty Dollars ($50.00) per rentable square foot of the Premises (the “Additional Allowance”), which amount may be used by Tenant to increase the scope of Core and Shell Work or the Tenant Improvements pursuant to the terms and
conditions contained in the Work Letter. In the event Tenant elects to use the Additional Allowance, Tenant 

  
 -6- 

 
shall pay to Landlord, as Rent, an amount equal to the drawn portion of the Additional Allowance, amortized over the initial Term at an interest rate of ten percent (10%) per annum. Tenant
shall make payments in respect of the Additional Allowance plus interest thereon in equal monthly installments so that the full amount shall be paid on or before the expiration of the initial Term. Tenant shall pay such amounts with the payment of
Basic Annual Rent for each month. If Tenant has not paid the full amount of the Additional Allowance plus interest thereon at the expiration or earlier termination of this Lease (unless such termination is due to an event of casualty or condemnation
for which Landlord receives sufficient insurance or condemnation proceeds with respect to the Tenant Improvements to fully compensate Landlord for the amortized value thereof as determined by Landlord in good faith), then upon the expiration or
termination of this Lease Tenant shall immediately pay the unpaid portion of such amount to Landlord. The payments Tenant is required to make in respect of the Additional Allowance shall constitute “Additional Rent” in accordance
with Section 6.2 hereof. Tenant shall be entitled to prepay the Additional Allowance at any time, without penalty. 
 4.3
Warranties. Landlord shall diligently endeavor to cause Contractor to complete with reasonable promptness the Punchlist Items and repair with reasonable promptness all defects in the construction of (x) Core and Shell Work in accordance
with the Approved Core and Shell Plans, and (y) the Tenant Improvements in accordance with the Approved TI Plans, each as to which Tenant notifies Landlord in writing (which notice Tenant shall give within nine (9) months after the Term
Commencement Date). Except for such items, and except as otherwise set forth in this Lease, Tenant shall be deemed to have accepted the Premises in the condition delivered to it “As Is,” and Landlord shall have no liability to correct
other claimed defects; provided, however, except as to those items that Landlord is required to correct pursuant to this section, Landlord shall partially assign to Tenant (but without prejudice to any of Landlord’s rights of enforcement) all
warranties that it has received under the architect contracts, construction contracts or any subcontract, or from any material supplier. Landlord agrees to administer any claims in connection with such warranties in a reasonable manner. 

Notwithstanding the foregoing, Landlord further warrants that as of the Term Commencement Date the Premises shall (a) substantially
comply with all Applicable Laws (defined below); (b) be constructed substantially in conformance with the Approved TI Plans and Approved Core and Shell Plans; and (c) be watertight. To the extent any of the warranties set forth in the
preceding sentence are violated, Landlord shall promptly correct the same at its sole cost. 
 4.4 Expiration of TI Allowance
Obligations. So long as no uncured Default by Tenant exists, Tenant shall have until June 30, 2009 to expend the unused portion of the TI Allowance, after which date Landlord’s obligation to fund the TI Allowance shall expire.
Tenant’s right to use the unused portion of the TI Allowance will terminate if Tenant Defaults and fails to cure such Default prior to the expiration of any applicable cure period. 

5. Possession and Rent Commencement Date. 

5.1 Tenant’s Access. From and after the day that is thirty (30) days before the day when Landlord then expects the Term
Commencement Date to occur, Landlord shall permit Tenant 

  
 -7- 

 
to enter the Premises in order to inspect the same, move equipment and personal property into the Premises and perform installation or improvement work, so long as Tenant does not interfere with
Landlord’s installation and completion of the Core and Shell Work or Tenant Improvements; provided, however, Tenant shall furnish to Landlord evidence satisfactory to Landlord that insurance coverages required of Tenant under the
provisions of Article 22 are in effect, and such entry shall be subject to all the terms and conditions of this Lease other than the payment of Basic Annual Rent and Operating Expenses. 

5.2 Premises. Landlord shall endeavor to tender possession of the Premises (with the Tenant Improvements and the Core and Shell Work
Substantially Complete) to Tenant on or before the Estimated Delivery Date. If Core and Shell Work or the Tenant Improvements as required pursuant to the terms of the Work Letter are not Substantially Complete on or before the Estimated Delivery
Date for any reason whatsoever, then this Lease shall not be void or voidable, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom and the Term Commencement Date shall not occur until Substantial Completion of Core and
Shell Work and the Tenant Improvements occurs; provided, however, if the satisfaction of the requirements for Substantial Completion of Core and Shell Work or the Tenant Improvements have been delayed by any Tenant Delay, Substantial Completion of
Core and Shell Work and the Tenant Improvements shall be deemed to occur when (as reasonably determined by Landlord) Substantial Completion of Core and Shell Work and the Tenant Improvements would have occurred if such Tenant Delay had not occurred.
Within thirty (30) days after Substantial Completion of Core and Shell Work and the Tenant Improvements, Landlord’s architect shall calculate and certify in writing to Landlord and Tenant the Rentable Area of the Premises in accordance
with Article 9, which calculation must be approved by Landlord and Tenant (both hereby agreeing to act reasonably with respect to granting such approval). “Tenant Delay” shall mean any delay in the commencement or
completion of the Core and Shell Work or the TI Work that results from or arises out of any of the following: (1) delays or failure of Tenant to deliver items in accordance with the Work Letter attached hereto as Exhibit G;
(2) Tenant’s failure to fulfill its obligations as set forth in this Lease or the Work Letter (including any failure to review or approve or disapprove any items in accordance with the Work Letter); (3) delays caused by Tenant Change
Order Requests (as defined in the Work Letter) or TI Tenant Change Order Requests (as defined in the Work Letter); (4) unavailability of materials, components or finishes for Core and Shell Work or the Tenant Improvements that differ from
Landlord’s standard work or that have an unusually long lead-time for delivery; (5) a willful or negligent act or omission of Tenant or Tenant’s Agents that interferes with the progress of the work; (6) failure of Landlord and
Tenant to agree (for any reason, provided Landlord acts in good faith and diligently to work with Tenant with respect to the Budget) on a mutually agreeable Budget within ten (10) calendar days after Landlord delivers a draft Budget to Tenant
or any request by Tenant that the scope of the Tenant Improvements be modified in connection with the Budget; or (7) delays caused by any revision to the Budget or TI Tenant Change Order Request. Landlord shall endeavor in good faith to provide
Tenant with at least thirty (30) days prior written notice of the date when Landlord believes the Term Commencement Date will occur. 

5.3 Acknowledgement. Landlord and Tenant shall each execute and deliver to the other written acknowledgment of the actual Term
Commencement Date and the Term Expiration 

  
 -8- 

 
Date when such is established, and shall attach it to this Lease as Exhibit B. Failure to execute and deliver such acknowledgement, however, shall not affect the Rent Commencement
Date or Landlord’s or Tenant’s liability hereunder. Failure by Tenant to obtain validation by any medical review board or other similar governmental licensing of the Premises required for the Permitted Use by Tenant shall not serve to
extend the Term Commencement Date. 
 6. Rent. 

6.1 Commencing on the Rent Commencement Date, Tenant shall pay to Landlord as Basic Annual Rent for the Premises the sums set forth in
Section 2.3, subject to the rental adjustments provided in Article 7 hereof. Basic Annual Rent shall be paid in equal monthly installments as set forth in Section 2.3, subject to the rental adjustments provided in
Article 7 hereof, each in advance on the first day of each and every calendar month during the Term. 
 6.2 In addition to Basic
Annual Rent, from and after the Term Commencement Date, Tenant shall pay to Landlord as additional rent (“Additional Rent”) at times hereinafter specified in this Lease (a) Tenant’s pro rata share, as set forth in
Section 2.2 (“Tenant’s Pro Rata Share”), of Operating Expenses as provided in Article 8 and (b) any other amounts that Tenant assumes or agrees to pay under the provisions of this Lease that are
owed to Landlord, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure on Tenant’s part to comply with the agreements, terms, covenants and conditions of this Lease to be
performed by Tenant, after notice and the lapse of any applicable cure periods. 
 6.3 Basic Annual Rent and Additional Rent shall together
be denominated “Rent.” Rent shall be paid to Landlord, without abatement, deduction or offset (except as otherwise set forth in this Lease), in lawful money of the United States of America at the office of Landlord as set forth in
Section 2.10 or to such other person or at such other place as Landlord may from time designate in writing. In the event the Term commences or ends on a day other than the first day of a calendar month, then the Rent for such fraction of
a month shall be prorated for such period on the basis of a thirty (30) day month and shall be paid at the then-current rate for such fractional month. 

7. Rent Adjustments. The Basic Annual Rent shall be subject to an annual upward adjustment of three percent (3%) of the
then-current Basic Annual Rent. The first such adjustment shall become effective commencing with that monthly rental installment that is due on or after the first (1st) annual anniversary of the Rent Commencement Date and subsequent adjustments
shall become effective on every successive annual anniversary for so long as this Lease continues in effect. 
 8. Operating
Expenses. 
 8.1 As used herein, the term “Operating Expenses” shall include: 

(a) Government impositions including, without limitation, property tax costs consisting of real and personal property taxes and assessments
(including amounts due under any improvement bond upon the Building or the Project, including the parcel or parcels of real 

  
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property upon which the Building and areas serving such Building are located or assessments in lieu thereof imposed by any federal, state, regional, local or municipal governmental authority,
agency or subdivision (each, a “Governmental Authority”) are levied); taxes on or measured by gross rentals received from the rental of space in the Building; taxes based on the square footage of the Premises, the Building or the
Project, as well as any parking charges, utilities surcharges or any other costs levied, assessed or imposed by, or at the direction of, or resulting from Applicable Laws (as defined below) or interpretations thereof, promulgated by any Governmental
Authority in connection with the use or occupancy of the Building or the parking facilities serving the Building; taxes on this transaction or any document to which Tenant is a party creating or transferring an interest in the Premises; any fee for
a business license to operate an office building; and any expenses, including the reasonable cost of attorneys or experts, reasonably incurred by Landlord in seeking reduction by the taxing authority of the applicable taxes, less tax refunds
obtained as a result of an application for review thereof. Operating Expenses shall not include any net income, franchise, capital stock, estate or inheritance taxes, or taxes that are the personal obligation of Tenant or of another tenant of the
Project; and 
 (b) All other costs of any kind paid or incurred by Landlord in connection with the operation or maintenance of the
Building and the Project including, by way of example and not of limitation, costs of repairs and replacements to improvements within the Project as appropriate to maintain the Project as required hereunder, including costs of funding such
reasonable reserves as Landlord, consistent with good business practice, may establish to provide for future repairs and replacements; costs of utilities furnished to the Common Areas; sewer fees; cable television; trash collection; cleaning,
including windows; heating; ventilation; air-conditioning; maintenance of landscaping and grounds; maintenance of drives and parking areas; maintenance of the root security services and devices; building
supplies; maintenance or replacement of equipment utilized for operation and maintenance of the Project; license, permit and inspection fees; sales, use and excise taxes on goods and services purchased by Landlord in connection with the operation,
maintenance or repair of the Project or Building systems and equipment; telephone, postage, stationery supplies and other expenses incurred in connection with the operation, maintenance or repair of the Project; accounting, legal and other
professional fees and expenses incurred in connection with the Project; costs of furniture, draperies, carpeting, landscaping and other customary and ordinary items of personal property provided by Landlord for use in Common Areas or in the Building
office; Building office rent or rental value for a commercially reasonable amount of space, to the extent an office used for Building operations is maintained at the Building; capital expenditures; costs of complying with all federal, state,
municipal and local laws, codes, ordinances, rules and regulations of Governmental Authorities, committees, associations, or other regulatory committees, agencies or governing bodies having jurisdiction over the Property, the Project, the Building,
the Premises, Landlord or Tenant, including both statutory and common law and hazard waste rules and regulations (“Applicable Laws”); reasonable insurance premiums, including premiums for public liability, property casualty,
earthquake, terrorism and environmental coverages; portions of insured losses paid by Landlord as part of any commercially reasonable deductible portion of a loss pursuant to the terms of insurance policies; service contracts; costs of services of
independent contractors retained to do work of a nature referenced above; and costs of compensation (including employment taxes and fringe benefits) of all persons who perform regular and recurring 

  
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duties connected with the day-to-day operation and maintenance of the Project, its equipment, the adjacent walks,
landscaped areas, drives and parking areas, including, without limitation, janitors, floor waxers, window washers, watchmen, gardeners, sweepers and handymen. 

Notwithstanding the foregoing, Operating Expenses shall not include any leasing commissions; expenses that relate to preparation of rental
space for a tenant; expenses of initial development and construction, including, but not limited to, initial costs of tools and equipment provided for the initial commencement of operations, grading, paving, landscaping and decorating (as
distinguished from maintenance, repair and replacement of the foregoing); legal expenses relating to other tenants; costs of repairs to the extent reimbursed by payment of insurance proceeds received by Landlord; interest upon loans to Landlord or
secured by a mortgage or deed of trust covering the Project or a portion thereof (provided that interest upon a government assessment or improvement bond payable in installments shall constitute an Operating Expense under
Subsection 8.1(a)); salaries of executive officers of Landlord; depreciation claimed by Landlord for tax purposes (provided that this exclusion of depreciation is not intended to delete from Operating Expenses actual costs of
repairs and replacements and reasonable reserves in regard thereto that are provided for in Subsection 8.1(b) and otherwise allowable under this Lease); and taxes of the types that are excluded from Operating Expenses by the last
sentence of Subsection 8.1(a); fees and costs, advertising and promotional expenses and other costs incurred in procuring tenants or in selling the Building or Project; legal fees incurred in connection with approvals from and contract
disputes with suppliers; costs of renovating or otherwise improving or decorating space for any tenant or other occupant of the Building or Project, including Tenant, or relocating any tenant; financing costs including interest and principal
amortization of debts and the costs of providing the same; rental on ground leases or other underlying leases and the costs of providing the same; wages, bonuses and other compensation of employees above the grade of Building Manager; any
liabilities, costs or expenses associated with or incurred in connection with the removal, enclosure, encapsulation of, and the cost of defending against claims in regard to the existence or release of, Hazardous Substances or materials at the
Building or Project which result from Landlord’s gross negligence or willful misconduct (except with respect to those costs for which Tenant is otherwise responsible pursuant to the express terms of this Lease); costs of any items for which,
and to the extent, Landlord is paid or reimbursed by insurance; increased insurance or Real Estate Taxes which are paid by any tenant of the Building or Project or for which Landlord is reimbursed from any other tenant; charges for electricity,
water, or other utilities, services or goods and applicable taxes for which Tenant or any other tenant, occupant, person or other party reimburses Landlord or pays to third parties; any violation of Applicable Laws to the extent that such violation
exists as of the Term Commencement Date; cost of any HVAC, janitorial or other services provided to tenants on an extra cost basis after regular business hours and for which such tenants reimburse Landlord; cost of installing, operating and
maintaining any specialty service, such as an observatory, broadcasting facilities, child or daycare, luncheon club or athletic or recreation club; any costs, expenses or fees associated with the initial construction of the Building or Project; cost
of any work or service performed on an extra cost basis for any tenant in the Building or Project to a materially greater extent or in a materially more favorable manner than furnished generally to the tenants and other occupants; cost of any work
or services performed for any facility other than the Building or Project; any cost representing an amount paid to a person, firm, corporation or other entity related to Landlord that is in excess of the

  
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amount which would have been paid in the absence of such relationship; any cost of painting or decorating any interior parts of the Building or Project other than Common Areas; any cost
associated with operating an on-or off-site management office for the Building or Development; Landlord’s general overhead and any other expense not directly
attributable to operation and management of the Building and Project (e.g., the activities of Landlord’s officers and executives or professional development expenditures); cost of initial cleaning and rubbish removal from the Building or
Project to be performed before final completion of the base building or tenant space; cost of initial landscaping of the Building or Project; attorneys’ fees, accounting fees and other expenditures incurred in connection with negotiations,
disputes and claims of other tenants or occupants of the Building or Project; late fees or charges incurred by Landlord due to late payment of expenses resulting from Landlord’s negligence or willful misconduct; cost of acquiring, securing,
cleaning or maintaining sculptures, paintings and other works of art; taxes on Landlord’s business (such as income, excess profits, franchise, capital stock, estate, inheritance, etc.); charitable or political contributions; costs and expenses
incurred in connection with compliance with or the contesting or settlement of any claimed violation of law or requirements of law; costs incurred because of any failure of the Project to comply with Applicable Laws, which failure exists as of the
Term Commencment Date; direct costs or allocable costs associated with parking operations if there is a separate charge to Tenant, other tenants or the public for parking; and all other items for which another party compensates or pays so that
Landlord shall not recover any item of cost more than once. 
 Furthermore, Operating Costs shall not include the cost of capital
improvements (but shall include costs of capital repairs and replacements), except for (A) the annual amortization (amortized over the lesser of ten (10) years or the useful life as reasonably determined by Landlord) of costs incurred by
Landlord after the Commencement Date for any capital improvements installed or paid for by Landlord and required by any laws, rules or regulations of any governmental or quasi-governmental authority due to a violation that does not exist on the Term
Commencement Date of any such law, rule or regulation; (B) the annual amortization (amortized over the lesser of ten (10) years or the useful life as reasonably determined by Landlord) of costs of any equipment, device or capital
improvement purchased or incurred as a labor-saving measure or to effect other economics in the operation or maintenance of the Building; or (C) minor capital improvements, tools or expenditures to the extent each such improvement or
acquisition costs less than Fifty Thousand Dollars ($50,000.00). 
 Landlord shall at all times use commercially reasonable efforts to
endeavor to operate the Building and Project in an economically reasonable manner at costs not disproportionately higher than those experienced by other comparable buildings in the Seattle area. 

8.2 Tenant shall pay to Landlord on the first day of each calendar month of the Term, as Additional Rent, (a) the Property Management Fee
(as defined below) and (b) Landlord’s estimate of Tenant’s Pro Rata Share of Operating Expenses with respect to the Building for such month. 

  
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 (x) The “Property Management Fee” shall equal three percent (3%) of the
Basic Annual Rent due from Tenant. 
 (y) Within ninety (90) days after the conclusion of each calendar year (or such longer period as
may be reasonably required by Landlord), Landlord shall furnish to Tenant a statement showing in reasonable detail the actual Operating Expenses and Tenant’s Pro Rata Share of Operating Expenses for the previous calendar year. Any additional
sum due from Tenant to Landlord shall be due and payable within thirty (30) days. If the amounts paid by Tenant pursuant to this Section 8.2 exceed Tenant’s Pro Rata Share of Operating Expenses for the previous calendar year,
then Landlord shall credit the difference against the Rent next due and owing from Tenant; provided that, if the Lease term has expired, Landlord shall accompany said statement with payment for the amount of such difference. 

(z) Any amount due under this Section 8.2 for any period that is less than a full month shall be prorated (based on a thirty (30)-day month) for such fractional month. 
 8.3 Landlord’s annual statement shall be final and
binding upon Tenant unless Tenant, within ninety (90) days after Tenant’s receipt thereof, shall contest any item therein by giving written notice to Landlord, specifying each item contested and the reasons therefor. If, during such ninety
(90)-day period, Tenant reasonably and in good faith questions or contests the correctness of Landlord’s statement of Tenant’s Pro Rata Share of Operating Expenses, Landlord shall provide Tenant with
reasonable access to review Landlord’s books and records to the extent relevant to determination of Operating Expenses, and such information as Landlord reasonably determines to be responsive to Tenant’s written inquiries regarding the
same. In the event that, after Tenant’s review of such information, Landlord and Tenant (both acting in good faith) cannot agree upon the amount of Tenant’s Pro Rata Share of Operating Expenses, then Tenant shall have the right to have an
independent public accounting firm hired by Tenant on an hourly basis and not on a contingent-fee basis (at Tenant’s sole cost and expense except as provided below), subject to a reasonable
confidentiality agreement and approved by Landlord (which approval Landlord shall not unreasonably withhold or delay) audit and review such of Landlord’s books and records for the year in question as directly relate to the determination of
Operating Expenses for such year (the “Independent Review”). Landlord shall make such books and records available at the location where Landlord maintains them in the ordinary course of its business. Landlord need not provide copies
of any books or records. Tenant shall commence the Independent Review within thirty (30) days after the date Landlord has given Tenant access to Landlord’s books and records for the Independent Review. Tenant shall complete the Independent
Review and notify Landlord in writing of Tenant’s specific objections to Landlord’s calculation of Operating Expenses (including a written statement of the basis, nature and amount of each proposed adjustment) no later than ninety
(90) days after Landlord has first given Tenant access to Landlord’s books and records for the Independent Review. Landlord shall review the results of any such Independent Review. The parties shall endeavor in good faith to agree promptly
and reasonably upon Operating Expenses taking into account the results of such Independent Review. If, as of sixty (60) days after Tenant has submitted the Independent Review to Landlord, the parties have not agreed on the appropriate
adjustments to Operating Expenses, then the parties shall engage a mutually agreeable independent 

  
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third party accountant with at least ten (10) years’ experience in commercial real estate accounting in the Seattle, Washington area (the “Accountant”). If the parties
cannot agree on the Accountant, each shall within ten (10) days after such impasse appoint an Accountant (different from the accountant and accounting firm that conducted the Independent Review) and, within ten (10) days after the
appointment of both such Accountants, those two Accountants shall select a third (which cannot be the accountant and accounting firm that conducted the Independent Review). If either party fails to timely appoint an Accountant, then the Accountant
the other party appoints shall be the sole Accountant. Within ten (10) days after appointment of the Accountant(s), Landlord and Tenant shall each simultaneously give the Accountants (with a copy to the other party) its determination of
Operating Expenses, with such supporting data or information as each submitting party determines appropriate. Within ten (10) days after such submissions, the Accountants shall by majority vote select either Landlord’s or Tenant’s
determination of Operating Expenses. The Accountants may not select or designate any other determination of Operating Expenses. The determination of the Accountant(s) shall bind the parties. If the parties agree or the Accountant(s) determine that
Tenant’s Pro Rata Share of Operating Expenses actually paid for the calendar year in question exceeded Tenant’s obligations for such calendar year, then Landlord shall, at Tenant’s option, either (a) credit the excess to the next
succeeding installments of estimated Additional Rent or (b) pay the excess to Tenant within thirty (30) days after delivery of such results. If the parties agree or the Accountant(s) determine that Tenant’s payments of Tenant’s
Pro Rata Share of Operating Expenses for such calendar year were less than Tenant’s obligation for the calendar year, then Tenant shall pay the deficiency to Landlord within thirty (30) days after delivery of such results. If it is finally
agreed or determined that Landlord’s annual statement for any year overcharges Tenant by 5% or more, then Landlord shall reimburse Tenant all reasonable costs of such review (including without limitation the cost of third party auditors) within
thirty (30) days of Landlord’s receipt of an invoice therefor. 
 8.4 Tenant shall not be responsible for Operating Expenses
attributable to the time period prior to the Term Commencement Date; provided, however, that if Landlord shall permit Tenant possession of the Premises prior to the Term Commencement Date, Tenant shall be responsible for Operating
Expenses from such earlier date of possession. Tenant’s responsibility for Tenant’s Pro Rata Share of Operating Expenses shall continue to the latest of (a) the date of termination of the Lease, (b) the date Tenant has fully
vacated the Premises or (c) if termination of the Lease is due to a default by Tenant, the date of rental commencement of a replacement tenant. 

8.5 Operating Expenses for the calendar year in which Tenant’s obligation to share therein commences and for the calendar year in which
such obligation ceases shall be prorated on a basis reasonably determined by Landlord. Expenses such as taxes, assessments and insurance premiums that are incurred for an extended time period shall be prorated based upon the time periods to which
they apply so that the amounts attributed to the Premises relate in a reasonable manner to the time period wherein Tenant has an obligation to share in Operating Expenses. 

8.6 Within seven (7) business days after the end of each calendar month, Tenant shall submit to Landlord an invoice, or, in the event an
invoice is not available, an itemized list, of all costs and expenses that (a) Tenant has incurred (either internally or by employing third parties) 

  
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during the prior month and (b) for which Tenant reasonably believes it is entitled to reimbursements from Landlord pursuant to the terms of this Lease or that Tenant reasonably believes is
the responsibility of Landlord pursuant to this Lease or the Work Letter. 
 9. Rentable Area. 

9.1 The term “Rentable Area” as set forth in Article 2 and as referenced within the Work Letter, and as may
otherwise be referenced within this Lease, shall reflect such areas as reasonably calculated by Landlord’s architect. 
 9.2 The
“Rentable Area” of the Building is generally determined by making separate calculations of Rentable Area applicable to each floor within the Building and totaling the Rentable Area of all floors within the Building. The Rentable
Area of a floor is computed by measuring to the outside finished surface of the permanent outer Building walls. The full area calculated as previously set forth is included as Rentable Area, without deduction for columns and projections or vertical
penetrations, including stairs, elevator shafts, flues, pipe shafts, vertical ducts and the like, as well as such items’ enclosing walls. Rentable Area throughout the Building shall be determined by Landlord via a consistent methodology. 

9.3 Except as set forth in Section 9.6, the term “Rentable Area,” when applied to the Premises, is that area equal to
the usable area of the Premises, plus an equitable allocation of Rentable Area within the Building that is not then utilized or expected to be utilized as usable area, including, but not limited to, that portion of the Building devoted to corridors,
equipment rooms, restrooms, elevator lobby, atrium and mailroom. In making such allocations, consideration shall be given to tenants benefited by space allocated such that the area that primarily serves tenants of only one floor, such as corridors
and restrooms upon such floor, shall be allocated to usable area of the Building, as a whole. Landlord shall provide Tenant with a detailed summary of its calculation of the Premises Rentable Area. 

9.4 Review of allocations of Rentable Areas as between tenants of the Building and the Project shall be made as frequently as Landlord deems
appropriate in order to facilitate an equitable apportionment of Operating Expenses. 
 9.5 Final measurement of the Rentable Area of the
Premises and the Building shall be determined by Landlord or Landlord’s architect and confirmed by Tenant with respect to this Lease. To the extent that the actual Premises as finally measured are larger or smaller than the approximate Rentable
Area set forth in Section 2.2 of this Lease, the Basic Annual Rent, Tenant’s Pro Rata Share of the Building, the amount of the Security Deposit, the TI Allowance and Additional Allowance of the Premises (and such other variables in
this Lease as are a function of Rentable Area) shall all be adjusted accordingly. If Tenant notifies Landlord within fifteen (15) days after receiving the final determination of the Rentable Area and supporting documentation for the same that
Tenant disagrees with the determination of the Rentable Area as calculated by Landlord or Landlord’s architect, the matter shall be arbitrated by a single arbitrator in accordance with Commercial Arbitration Rules of the American Arbitration
Association. The arbitrator’s decision shall be limited to determining the square footage of the Rentable Area. The arbitrator shall have no 

  
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authority to make any other rulings or fashion any remedy. The decision of the arbitrator shall be final. The party losing the arbitration shall reimburse the prevailing party for all of the
prevailing party’s fees, costs and expenses of the arbitration, including attorneys’ fees and the arbitrator’s fees. 
 9.6
Landlord and Tenant intend to include the Storage Rooms within the Premises, but intend that Tenant will occupy the Storage Rooms without paying Basic Annual Rent for, or a share of Operating Expenses allocated to, the Storage Rooms, and that the TI
Allowance will be calculated without regard to the Storage Rooms. As such, the Storage Rooms shall be excluded from the Rentable Area of the Premises for purposes of determining the Basic Annual Rent, Tenant’s Pro Rata Share of the Building and
the amount of the TI Allowance, and the amounts set forth in Sections 2.2 and 2.3 have been calculated on that basis. 

10. Security Deposit. 

10.1 Tenant shall deposit with Landlord within five (5) days of the Execution Date a security deposit in the amount set forth in
Section 2.8 (the “Security Deposit”), which Security Deposit shall be held by Landlord as security for the faithful performance by Tenant of all of the terms, covenants and conditions of this Lease to be kept and
performed by Tenant during the period commencing on the Execution Date and ending upon the expiration or termination of this Lease. If Tenant defaults with respect to any provision of this Lease, including, but not limited to, any provision relating
to the payment of Rent, then Landlord may (but shall not be required to) use, apply or retain all or any part of the Security Deposit for the payment of any Rent or any other sum in default, or to compensate Landlord for any other loss or damage
that Landlord may suffer by reason of Tenant’s default. If any portion of the Security Deposit is so used or applied, then Tenant shall, within ten (10) days following demand therefor, increase the amount of the L/C Security or deposit
cash with Landlord in an amount sufficient to restore the Security Deposit to its required amount, and Tenant’s failure to do so shall be a material breach of this Lease. The provisions of this Article 10 shall survive the
expiration or earlier termination of this Lease. 
 10.2 In the event of bankruptcy or other debtor-creditor proceedings against Tenant, the
Security Deposit shall be deemed to be applied first to the payment of Rent and other charges due Landlord for all periods prior to the filing of such proceedings. 

10.3 Landlord may deliver to any purchaser of Landlord’s interest in the Premises the funds deposited hereunder by Tenant, and thereupon
Landlord shall be discharged from any further liability with respect to such deposit. This provision shall also apply to any subsequent transfers. 

10.4 If Tenant shall fully and faithfully perform every provision of this Lease to be performed by it, then the Security Deposit, or any
balance thereof, shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) days after the expiration or earlier termination of this Lease. 

  
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 10.5 The Security Deposit may be in the form of cash, a letter of credit or any other security
instrument acceptable to Landlord in its sole discretion. Tenant may at any time, except during Default, deliver a letter of credit (the “L/C Security”) as the entire Security Deposit, as follows. 

(a) If Tenant elects to deliver L/C Security, then Tenant shall provide Landlord, and maintain in full force and effect throughout the Term,
a letter of credit in the form of Exhibit H issued by an issuer reasonably satisfactory to Landlord, in the amount of the Security Deposit, with an initial term of at least one year. If, at the Term Expiration Date, any Rent remains
uncalculated or unpaid, then: (i) Landlord shall with reasonable diligence complete any necessary calculations; and (ii) Tenant shall extend the expiry date of such L/C Security from time to time as Landlord reasonably requires (not to
exceed 30 days). Tenant shall reimburse Landlord’s reasonable legal costs (as reasonably estimated by Landlord’s counsel) in handling Landlord’s acceptance of L/C Security or its replacement or extension. 

(b) If Tenant delivers to Landlord satisfactory L/C Security in place of the entire Security Deposit, Landlord shall remit to Tenant any cash
Security Deposit Landlord previously held. 
 (c) Landlord may draw upon the L/C Security, and hold and apply the proceeds in the same
manner and for the same purposes as the Security Deposit, if: (i) an uncured Default exists; (ii) as of the date 45 days before any L/C Security expires (even if such scheduled expiry date is after the Term Expiration Date) Tenant has not
delivered to Landlord an amendment or replacement for such L/C Security, reasonably satisfactory to Landlord, extending the expiry date to the earlier of (1) six (6) months after the then-current Term Expiration Date or (2) the date
one year after the then-current expiry date of the L/C Security; (iii) the L/C Security provides for automatic renewals, Landlord requests that the issuer confirm the current L/C Security expiry date (with a copy of such request to Tenant), and
the issuer fails to do so within fifteen (15) business days after Tenant and the issuer each receives such request; (iv) Tenant fails to pay (when and as Landlord reasonably requires) any bank charges for Landlord’s transfer of the
L/C Security; or (v) the issuer of the L/C Security ceases, or announces that it will cease, to maintain an office in the city where Landlord may present drafts under the L/C Security. This paragraph does not limit any other provisions of this
Lease allowing Landlord to draw the L/C Security under specified circumstances. If Landlord draws on the Security L/C, any amount that is not applied in accordance with Section 10.1 hereof shall be held as a cash Security Deposit. 

(d) Tenant shall not seek to enjoin, prevent, or otherwise interfere with Landlord’s draw under L/C Security, even if it violates this
Lease. Landlord shall hold the proceeds of any draw in the same manner and for the same purposes as a cash Security Deposit. In the event of a wrongful draw, the parties shall cooperate to allow Tenant to post replacement L/C Security simultaneously
with the return to Tenant of the wrongfully drawn sums, and Landlord shall upon request confirm in writing to the issuer of the L/C Security that Landlord’s draw was erroneous. 

(e) If Landlord transfers its interest in the Premises, then Tenant shall at Tenant’s expense, within fifteen (15) business days
after receiving a request from Landlord, deliver (and, if the issuer requires, Landlord shall consent to) an amendment to the L/C Security naming Landlord’s grantee as substitute beneficiary. If the required Security changes while L/C Security
is in force, then Tenant shall deliver (and, if the issuer requires, Landlord shall consent to) a corresponding amendment to the L/C Security. 

  
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 11. Use. 

11.1 Tenant shall use the Premises for the purpose set forth in Section 2.9, and shall not use the Premises, or permit or suffer
the Premises to be used, for any other purpose without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion. 

11.2 Tenant shall not use or occupy the Premises in violation of Applicable Laws; zoning ordinances; or the certificate of occupancy issued
for the Building, and shall, upon five (5) days’ written notice from Landlord, discontinue any use of the Premises that is declared or claimed by any Governmental Authority having jurisdiction to be a violation of any of the above, or that
in Landlord’s reasonable opinion violates any of the above. Tenant shall comply with any direction of any Governmental Authority having jurisdiction that shall, by reason of the nature of Tenant’s use or occupancy of the Premises, impose
any duty upon Tenant or Landlord with respect to the Premises or with respect to the use or occupation thereof. 
 11.3 Tenant shall not do
or permit to be done anything that will invalidate or increase (unless Tenant pays the increase for the duration of the increase (even if after the end of the Term)) the cost of any fire, environmental, extended coverage or any other insurance
policy covering the Building and the Project, and shall comply with all rules, orders, regulations and requirements of the insurers of the Building and the Project, and Tenant shall promptly, upon demand, reimburse Landlord for any additional
premium charged for such policy by reason of Tenant’s failure to comply with the provisions of this Article. 
 11.4 Tenant shall keep
all doors opening onto public corridors closed, except when in use for ingress and egress. 
 11.5 No additional locks or bolts of any kind
shall be placed upon any of the doors or windows by Tenant, nor shall any changes be made to existing locks or the mechanisms thereof without Landlord’s prior written consent, which shall not be unreasonably withheld, conditioned or delayed.
Tenant shall, upon termination of this Lease, return to Landlord all keys to offices and restrooms either furnished to or otherwise procured by Tenant. In the event any key so furnished to Tenant is lost, Tenant shall pay to Landlord the cost of
replacing the same or of changing the lock or locks opened by such lost key if Landlord shall deem it necessary to make such change. 
 11.6
No awnings or other projections shall be attached to any outside wall of the Building. No curtains, blinds, shades or screens shall be attached to or hung in, or used in connection with, any window or door of the Premises other than Landlord’s
standard window coverings without Landlord’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. Neither the interior nor exterior of any windows shall be coated or otherwise sunscreened without
Landlord’s prior written consent, which shall not be unreasonably withheld, conditioned or delayed. No equipment, furniture or other items of personal property shall be placed on any exterior balcony without Landlord’s prior written
consent, which shall not be unreasonably withheld, conditioned or delayed. 

  
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 11.7 No sign, advertisement or notice (“Signage”) shall be exhibited, painted or
affixed by Tenant on any part of the Premises or the Building without Landlord’s prior written consent, which shall not be unreasonably withheld, conditioned or delayed. Directory and suite entry identification for Tenant shall be provided for
Tenant by Landlord at Landlord’s sole cost and expense, and shall be of a size, color and type and be located in a place acceptable to Landlord. The directory tablet shall be provided exclusively for the display of the name and location of
tenants only. Tenant shall not place anything on the exterior of the corridor walls or corridor doors other than Landlord’s standard lettering without Landlord’s prior written consent, which shall not be unreasonably withheld, conditioned
or delayed. Tenant shall have Signage rights for the Premises substantially consistent with the Signage permitted for other comparable Tenants in the Project, as Landlord reasonably determines, including without limitation space on any monument sign
should one be constructed. At Landlord’s option, Landlord may install any such Signage, and Tenant shall pay all actual costs associated with such installation within thirty (30) days after demand therefor. 

11.8 Tenant shall use reasonable efforts consistent with a laboratory user to minimize the sounds or vibrations from equipment or machinery
installed by Tenant in the Premises that extend into the Common Areas or other offices in the Building. Further, Tenant shall only place equipment within the Premises with floor loading consistent with the structural design of the Building (unless
Tenant otherwise obtains Landlord’s prior written approval, which shall not be unreasonably withheld, conditioned or delayed) and such equipment shall be placed in a location designed to carry the weight of such equipment. 

11.9 Tenant shall not (a) do or permit anything to be done in or about the Premises that shall in any way unreasonably obstruct or
interfere with the rights of other tenants or occupants of the Building or the Project, or injure or annoy them, (b) use or allow the Premises to be used for immoral, unlawful or objectionable purposes, (c) cause, maintain or permit any
nuisance or waste in, on or about the Premises, the Building or the Project or (d) take any other action that would in Landlord’s reasonable determination in any manner materially adversely affect other tenants’ quiet use and
enjoyment of their space or adversely impact their ability to conduct business in a professional and suitable work environment. 
 11.10
Notwithstanding any other provision herein to the contrary, but subject to Landlord’s obligations and warranties under this Lease (including without limitation Section 4.3) Tenant shall be responsible for all liabilities, costs and
expenses arising out of or in connection with the compliance of the Premises with the Americans with Disabilities Act, 42 U.S.C. § 12101, et seq. (together with regulations promulgated pursuant thereto, the “ADA”), and
Tenant shall indemnify, defend and hold harmless Landlord from and against any loss, cost, liability or expense (including reasonable attorneys’ fees and disbursements) arising out of any failure of the Premises to comply with the ADA. The
provisions of this Section 11.10 shall survive the expiration or earlier termination of this Lease. 

  
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 12. Brokers. 

12.1 Tenant represents and warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of
this Lease other than The Staubach Company (“Tenant’s Broker”), and that it knows of no other real estate broker or agent that is or might be entitled to a commission in connection with this Lease (other than Landlord’s
Broker, as set forth in Section 12.2 hereof). Landlord shall compensate Tenant’s Broker in relation to this Lease pursuant to a separate agreement between Landlord and Tenant’s Broker. 

12.2 Landlord represents and warrants that it has had no dealing with any real estate broker or agent in connection with the negotiation of
this Lease other than EDG Commercial Real Estate (“Landlord’s Broker”) and that it knows of no other real estate broker or agent that is or might be entitled to a commission in connection with this Lease (other than
Tenant’s Broker, as set forth in Section 12.1 hereof). Landlord shall compensate Landlord’s Broker in relation to this Lease pursuant to a separate agreement between Landlord and Landlord’s Broker. 

12.3 Tenant represents and warrants that no broker or agent has made any representation or warranty relied upon by Tenant in Tenant’s
decision to enter into this Lease, other than as contained in this Lease. 
 12.4 Tenant acknowledges and agrees that the employment of
brokers by Landlord is for the purpose of solicitation of offers of leases from prospective tenants and that no authority is granted to any broker to furnish any representation (written or oral) or warranty from Landlord unless expressly contained
within this Lease. Landlord is executing this Lease in reliance upon Tenant’s representations, warranties and agreements contained within Sections 12.1 and 12.3. 

12.5 Tenant agrees to indemnify, defend and hold Landlord harmless from any and all cost or liability for compensation claimed by any other
broker or agent, other than Tenant’s Broker, employed or engaged by it or claiming to have been employed or engaged by Tenant. Landlord agrees to indemnify, defend and hold Tenant harmless from any and all cost or liability for compensation
claimed by any other broker or agent, other than Landlord’s Broker, employed or engaged by it or claiming to have been employed or engaged by Landlord. 

13. Holding Over. 
 13.1
If, with Landlord’s prior written consent, Tenant holds possession of all or any part of the Premises after the Term, Tenant shall become a tenant from month to month after the expiration or earlier termination of the Term, and in such case
Tenant shall continue to pay (a) the Basic Annual Rent in accordance with Article 6, as adjusted in accordance with Article 7, and (b) Tenant’s Pro Rata Share of Operating Expenses. Any such month-to-month tenancy shall be subject to every other term, covenant and agreement contained herein. 

13.2 Notwithstanding the foregoing, if Tenant remains in possession of the Premises after the expiration or earlier termination of the Term
without Landlord’s prior written consent, Tenant shall become a tenant at sufferance subject to the terms and conditions of this Lease, except that the monthly rent shall be equal to one hundred fifty percent (150%) of the Rent in effect
during the last thirty (30) days of the Term. 

  
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 13.3 Acceptance by Landlord of Rent after the expiration or earlier termination of the Term shall
not result in an extension, renewal or reinstatement of this Lease. 
 13.4 The foregoing provisions of this Article 13 are in
addition to and do not affect Landlord’s right of reentry or any other rights of Landlord hereunder or as otherwise provided by Applicable Laws. 

14. Taxes on Tenant’s Property. 

14.1 Tenant shall pay prior to delinquency any and all taxes levied against any personal property or trade fixtures placed by Tenant in or
about the Premises. 
 14.2 If any such taxes on Tenant’s personal property or trade fixtures are levied against Landlord or
Landlord’s property or, if the assessed valuation of the Building or the Property is increased by inclusion therein of a value attributable to Tenant’s personal property or trade fixtures, and if Landlord, after written notice to Tenant,
pays the taxes based upon any such increase in the assessed valued of the Building or the Project, then Tenant shall, upon demand, repay to Landlord the taxes so paid by Landlord. 

14.3 If any improvements in or Alterations to the Premises, whether owned by Landlord or Tenant and whether or not affixed to the real
property so as to become a part thereof, are assessed for real property tax purposes at a valuation higher than the valuation at which improvements conforming to Landlord’s building standards (the “Building Standard”) in other
spaces in the Building are assessed, then the real property taxes and assessments levied against Landlord or the Building by reason of such excess assessed valuation shall be deemed to be taxes levied against personal property of Tenant and shall be
governed by the provisions of Section 14.2 above. Any such excess assessed valuation due to improvements in or alterations to space in the Building leased by other tenants of Landlord shall not be included in the Operating Expenses
defined in Article 8, but shall be treated, as to such other tenants, as provided in this Section 14.3. If the records of the County Assessor are available and sufficiently detailed to serve as a basis for deteunining whether
said Tenant improvements or alterations are assessed at a higher valuation than the Building Standard, then such records shall be binding on both Landlord and Tenant. 

15. Condition of Premises. Tenant acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty
with respect to the condition of the Premises, the Building or the Project, or with respect to the suitability of the Premises, the Building or the Project for the conduct of Tenant’s business, except as otherwise set forth in this Lease.
Tenant acknowledges that subject to Landlord’s representations, warranties and obligations set forth in this Lease (a) it agrees to take the Premises in their condition “as is” as of the Temi Commencement Date, except as
otherwise set forth in this Lease and (b) Landlord shall have no obligation to alter, repair or otherwise prepare the Premises for Tenant’s occupancy or to pay for or construct any improvements to the Premises, except as otherwise set
forth in this Lease. 

  
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 16. Common Areas and Parking Facilities. 

16.1 Tenant shall have the non-exclusive right, in common with others, to use the Common Areas,
subject to the rules and regulations adopted by Landlord and attached hereto as Exhibit D, together with such other reasonable and nondiscriminatory rules and regulations as are hereafter promulgated by Landlord in writing in its
reasonable discretion (the “Rules and Regulations”). Tenant shall faithfully observe and comply with the Rules and Regulations. Landlord shall not be responsible to Tenant for the violation or
non-performance by any other tenant or any agent, employee or invitee thereof of any of the Rules and Regulations. 

16.2 Tenant shall be entitled to rent from Landlord on a monthly basis from time to time throughout the Term an amount of parking spaces not
to exceed one (1) parking space (located in the Building garage) per One Thousand rentable square feet of the Premises (“Tenant’s Parking Space Allowance”) on an unreserved basis at a rate of One Hundred Seventy Five
Dollars ($175.00) per parking space per month, which rate shall be subject to annual market-based increases not greater than three percent (3%) per calendar year. Notwithstanding the foregoing, Landlord shall provide Tenant with Tenant’s
Parking Space Allowance for the first twelve (12) months following the Rent Commencement Date at no cost to Tenant. 
 16.3 Landlord
reserves the right to modify the Common Areas, including the right to add or remove exterior and interior landscaping and to subdivide real property, so long as such modifications do not materially adversely interfere with Tenant’s use and
enjoyment of the Premises. Tenant acknowledges that Landlord specifically reserves the right to allow the exclusive use of corridors and restroom facilities located on specific floors to one or more tenants occupying such floors; provided,
however, that Tenant shall not be deprived of the use of the corridors reasonably required to serve the Premises or of restroom facilities serving the floor upon which the Premises are located. 

17. Utilities and Services. 

17.1 Tenant shall pay for all water (including the cost to service, repair and replace reverse osmosis,
de-ionized and other treated water), gas, heat, light, power, telephone, internet service, cable television, other telecommunications and other utilities supplied to the Premises together with any fees,
surcharges and taxes thereon. If any such utility is not separately metered to Tenant, Tenant shall pay a reasonable proportion (to be determined by Landlord) of all charges of such utility jointly metered with other premises as part of
Tenant’s Pro Rata Share of Operating Expenses or, in the alternative, Landlord may, at its option, monitor the usage of such utilities by Tenant and charge Tenant with the cost of purchasing, installing and monitoring such metering equipment,
which cost shall be paid by Tenant as Additional Rent. 
 17.2 Landlord shall not be liable for, nor shall any eviction of Tenant result
from, the failure to furnish any utility or service, whether or not such failure is caused by accident, breakage, repair, Force Majeure or Tenant’s negligence or gross negligence. Tenant shall provide written notice to Landlord of any
interruption of a utility or service, and Landlord shall use commercially reasonable efforts to correct any such interruption within five (5) business days after receipt of such notice. In the event that such failure continues for such five
(5) business day period after Landlord’s receipt of such written notice from Tenant, Tenant shall be entitled to a full 

  
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abatement of Rent during the period beginning at the end of such five (5) business day period for the duration of any such interruption to the extent that the same materially interferes with
Tenant’s use of the Premises and to the extent that the same is due to Landlord’s gross negligence or intentional misconduct. 

17.3 Tenant shall pay for, prior to delinquency of payment therefor, any utilities and services that may be furnished to the Premises during
or, if Tenant occupies the Premises after the expiration or earlier termination of the Term, after the Term. 
 17.4 Tenant shall not,
without Landlord’s prior written consent (which shall not be unreasonably withheld, conditioned or delayed), use any device in the Premises (including, without limitation, data processing machines) that will in any way (a) increase the
amount of ventilation, air exchange, gas, steam, electricity or water beyond the existing capacity of the Building as proportionately allocated to the Premises based upon Tenant’s Pro Rata Share as usually furnished or supplied for the use set
forth in Section 2.9 or (b) exceed Tenant’s Pro Rata Share of the Building’s capacity to provide such utilities or services, unless Tenant installs additional equipment or installations with respect to such device that
prevent any adverse effect on the Building. 
 17.5 Tenant shall have the right to use the Building loading dock and freight elevator in
common with other tenants in the Building in a manner and with frequency proportionate to Tenant’s Pro Rata Share. 
 17.6 If Tenant
shall require utilities or services in excess of those usually furnished or supplied for tenants in similar spaces in the Building by reason of Tenant’s equipment or extended hours of business operations, then Tenant shall first procure
Landlord’s consent for the use thereof, which consent Landlord may reasonably condition upon the availability of such excess utilities or services, and Tenant shall pay as Additional Rent an amount equal to the cost of providing such excess
utilities and services. 
 17.7 Utilities and services provided by Landlord to the Premises that are separately metered shall be paid by
Tenant directly to the supplier of such utility or service if the same is practical; otherwise the same shall be paid to Landlord. 
 17.8
Landlord shall provide water in Common Areas for lavatory and water fountain purposes only. Tenant shall be entitled to use water in its Premises consistent with a laboratory user, and Landlord shall install a water meter to measure Tenant’s
water consumption for such purposes. Throughout the duration of Tenant’s occupancy of the Premises, Tenant shall keep said meter and installation equipment in good working order and repair at Tenant’s sole cost and expense. If Tenant fails
to so maintain such meter and equipment, Landlord may repair or replace the same and shall collect the costs therefor from Tenant. Tenant agrees to pay for water consumed, as shown on said meter, as and when bills are rendered. If Tenant fails to
timely make such payments, Landlord may pay such charges and collect the same from Tenant. Any such costs or expenses incurred, or payments made by Landlord for any of the reasons or purposes hereinabove stated, shall be deemed to be Additional Rent
payment by Tenant and collectible by Landlord as such. 

  
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 17.9 Landlord reserves the right to stop service of the elevator, plumbing, ventilation, air
conditioning and electric systems, when Landlord deems necessary or desirable, due to accident, emergency or the need to make repairs, alterations or improvements, until such repairs, alterations or improvements shall have been completed, and
Landlord shall further have no responsibility or liability for failure to supply elevator facilities, plumbing, ventilation, air conditioning or electric service when prevented from doing so by Force Majeure or a failure by a third party to deliver
gas, oil or another suitable fuel supply, or Landlord’s inability by exercise of reasonable diligence to obtain gas, oil or another suitable fuel; provided that Landlord shall use reasonable efforts to provide at least one (1) business day
advance written notice to Tenant (except in the event of an emergency) of any stop in service, repair, alteration or improvement that Landlord in good faith anticipates will materially and adversely impact Tenant, and Landlord further agrees to use
reasonable efforts to perform such work in a manner that keeps any disruption to Tenant to a reasonable level. Without limiting the foregoing, it is expressly understood and agreed that any covenants on Landlord’s part to furnish any service
pursuant to any of the terms, covenants, conditions, provisions or agreements of this Lease, or to perform any act or thing for the benefit of Tenant, shall not be deemed breached if Landlord is unable to furnish or perform the same by virtue of
Force Majeure. 
 18. Alterations. 

18.1 Tenant shall make no alterations, additions or improvements in or to the Premises or engage in any construction, demolition,
reconstruction, renovation, or other work (whether major or minor) of any kind in, at, or serving the Premises (“Alterations”) without Landlord’s prior written approval, which approval Landlord shall not unreasonably withhold,
condition or delay; provided, however, that in the event any proposed Alteration adversely affects (a) any structural portions of the Building, including exterior walls, roof, foundation or core of the Building, (b) the
exterior of the Building or (c) any Building systems, including elevator, plumbing, air conditioning, heating, electrical, security, life safety and power, then Landlord may withhold its approval with respect thereto in its sole and absolute
discretion. Tenant shall, in making any such Alterations, use only those architects, contractors, suppliers and mechanics of which Landlord has given prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed.
In seeking Landlord’s approval, Tenant shall provide Landlord, at least fourteen (14) days in advance of any proposed construction, with plans, specifications, bid proposals, work contracts, requests for laydown areas and such other
information concerning the nature and cost of the Alterations as Landlord may reasonably request. Notwithstanding the foregoing, Tenant shall not be required to seek Landlord’s prior consent to cosmetic Alterations in the Premises that cost
less than $50,000 in any one instance; provided, however, that in the event any proposed Alteration adversely affects (a) any structural portions of the Building, including exterior walls, roof, foundation or core of the Building,
(b) the exterior of the Building or (c) any Building systems, including elevator, plumbing, air conditioning, heating, electrical, security, life safety and power, then Tenant must obtain Landlord’s approval, and Landlord may withhold
such approval in its sole and absolute discretion. 

  
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 18.2 Tenant shall not construct or permit to be constructed partitions or other obstructions that
might interfere with free access to mechanical installation or service facilities of the Building, or interfere with the moving of Landlord’s equipment to or from the enclosures containing such installations or facilities, without first
obtaining Landlord’s approval, which shall not be unreasonably withheld, conditioned or delayed. 
 18.3 Tenant shall accomplish any
work performed on the Premises or the Building in such a manner as to permit any fire sprinkler system and fire water supply lines to remain fully operable at all times. 

18.4 Any work performed on the Premises or the Building by Tenant or Tenant’s contractors shall be done at such times and in such manner
as Landlord may from time to time reasonably designate. Tenant covenants and agrees that all work done by Tenant or Tenant’s contractors shall be performed in full compliance with Applicable Laws. Within thirty (30) days after completion
of any Alterations, if applicable, Tenant shall provide Landlord with complete “as-built” drawing print sets and electronic CADD files on disc (or files in such other current format in common use as
Landlord reasonably approves or requires) showing any changes in the Premises. Within sixty (60) days of the Term Commencement Date, Landlord shall provide Tenant with complete “as-built”
drawing print sets and electronic CADD files on disc (or files in such other current format in common use as Landlord reasonably approves or requires) for the Building, and agrees to provide Tenant with updates to the same to the extent necessary
for Tenant to efficiently provide Landlord with the deliverables required by the prior sentence. 
 18.5 All Tenant Improvements,
Alterations, attached equipment, decorations, fixtures, trade fixtures, additions and improvements, subject to Sections 18.8 and 20.3, attached to or built into the Premises, made by either of the Parties, including, without
limitation, all floor and wall coverings, built-in cabinet work and paneling, sinks and related plumbing fixtures, built-in laboratory benches, exterior venting fume
hoods and walk-in freezers and refrigerators, ductwork, conduits, electrical panels and circuits (collectively, “Attached Property”), shall (unless, prior to such construction or installation,
Landlord elects otherwise in writing) become the property of Landlord upon the expiration or earlier termination of the Term, and shall remain upon and be surrendered with the Premises as a part thereof. The Premises shall at all times remain the
property of Landlord and shall be surrendered to Landlord upon the expiration or earlier termination of this Lease. Notwithstanding the foregoing, upon termination of this Lease, Tenant shall have the right to remove any equipment,
laboratory/research equipment, decorations, trade fixtures and personal property from the Premises that was paid for entirely by Tenant and that is not affixed to the Building or the Property in a manner that removal of the same would require
substantial alteration (for example, trade fixtures that are merely bolted to the Building would not require substantial alteration to remove; but an item such as an installed walk-in freezer would require
substantial alterations to remove) (“Tenant’s Personal Property”); provided, however, Tenant shall repair any damage to the Premises associated with such removal. 

18.6 Before commencing any work, Tenant shall give Landlord at least fourteen (14) days’ prior written notice of the proposed
commencement of such work and shall, if required by Landlord, secure, at Tenant’s own cost and expense, a completion and lien indemnity bond satisfactory to Landlord for said work. 

  
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 18.7 Tenant shall repair any damage to the Premises caused by Tenant’s removal of any
property from the Premises. During any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. The provisions of this Section shall survive the expiration or earlier
termination of this Lease. 
 18.8 If Tenant shall fail to remove any of its property from the Premises prior to termination of this Lease,
then Landlord may, at its option, remove the same in any manner that Landlord shall choose and store said effects without liability to Tenant for loss thereof or damage thereto, and Tenant shall pay Landlord, upon demand, any costs and expenses
incurred due to such removal and storage or Landlord may, at its sole option and without notice to Tenant, sell such property or any portion thereof at private sale and without legal process for such price as Landlord may obtain and apply the
proceeds of such sale against any (a) amounts due by Tenant to Landlord under this Lease and (b) any expenses incident to the removal, storage and sale of said personal property. 

18.9 Notwithstanding any other provision of this Article 18 to the contrary, in no event shall Tenant remove any improvement from
the Premises as to which Landlord contributed payment, including, without limitation, the Tenant Improvements made pursuant to the Work Letter without Landlord’s prior written consent, which consent Landlord may withhold in its sole and
absolute discretion. 
 18.10 Tenant shall reimburse Landlord for any extra expenses incurred by Landlord by reason of faulty work done by
Tenant or its contractors, or by reason of delays caused by such work, or by reason of inadequate clean-up. 

18.11 Within sixty (60) days after final completion of the Tenant Improvements (or any other Alterations performed by Tenant with respect
to the Premises), Tenant shall pay to Landlord an amount equal to four percent (4%) of the cost to Tenant of all Alterations installed by Tenant or its contractors or agents to cover Landlord’s overhead and expenses for plan review,
coordination, scheduling and supervision thereof (the “Alteration Fee”); provided, however, that no Alteration Fee shall be payable for any Alterations which do not require any plan review, coordination, scheduling or
supervision; and provided, further, that the parties agree that the Alteration Fee shall not apply to the Tenant Improvements since Landlord will receive the Construction Management Fee as described in the Work Letter. For purposes of
payment of such sum, Tenant shall submit to Landlord copies of all bills, invoices and statements covering the costs of such charges, accompanied by payment to Landlord of the fee set forth in this Section. Tenant shall reimburse Landlord for any
extra expenses incurred by Landlord by reason of faulty work done by Tenant or its contractors, or by reason of delays caused by such work, or by reason of inadequate clean-up. 

  
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 18.12 Tenant shall require its contractors and subcontractors performing work on the Premises to
name Landlord and its affiliates and lenders (so long as Landlord notifies Tenant in writing of the identity of the same) as additional insureds on their respective insurance policies. 

19. Repairs and Maintenance. 

19.1 Landlord shall repair and maintain in good working condition the structural and exterior portions and Common Areas of the Building and
the Project and all Building systems and utilities, including, without limitation, roofing and covering materials, foundations, exterior walls, plumbing, fire sprinkler systems (if any), heating, ventilating, air conditioning, elevators, and
electrical systems installed or furnished by Landlord. Any costs related to the repair or maintenance activities specified in this Section 19.1 shall be included as a part of Operating Expenses to the extent allowable under
Article 8, unless such repairs or maintenance is required in whole or in part because of any act, neglect, fault or omissions of Tenant, its agents, servants, employees or invitees, in which case Tenant shall pay to Landlord the cost of such
repairs and maintenance. 
 19.2 Except for services of Landlord, if any, required by Section 19.1, Tenant shall at
Tenant’s sole cost and expense maintain and keep the Premises and every part thereof in good condition and repair, damage thereto from ordinary wear and tear excepted. Tenant shall, upon the expiration or sooner termination of the Term,
surrender the Premises to Landlord in as good of a condition as when received, ordinary wear and tear and casualty excepted. Landlord shall have no obligation to alter, remodel, improve, repair, decorate or paint the Premises or any part thereof,
other than pursuant to the terms and provisions of the Work Letter or this Lease. 
 19.3 Landlord shall not be liable for any failure to
make any repairs or to perform any maintenance that is an obligation of Landlord unless such failure shall persist for an unreasonable time after Tenant provides Landlord with written notice of the need of such repairs or maintenance. Tenant waives
its rights under Applicable Laws now or hereafter in effect to make repairs at Landlord’s expense. 
 19.4 Repairs under this
Article 19 that are obligations of Landlord are subject to allocation among Tenant and other tenants as Operating Expenses, except as otherwise provided in this Article 19. 

19.5 This Article 19 relates to repairs and maintenance arising in the ordinary course of operation of the Building and the
Project and any related facilities. In the event of fire, earthquake, flood, vandalism, war, terrorism, natural disaster or similar cause of damage or destruction, Article 23 shall apply in lieu of this Article 19. 

20. Liens. 
 20.1 Subject
to the immediately succeeding sentence, Tenant shall keep the Premises, the Building and the Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Tenant further covenants and agrees that
any mechanic’s lien filed against the Premises, the Building or the Project for work claimed to have been done for, or materials claimed to have been furnished to, shall be discharged or bonded by Tenant within fifteen (15) days after the
filing thereof, at Tenant’s sole cost and expense. 

  
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 20.2 Should Tenant fail to discharge or bond against any lien of the nature described in
Section 20.1, Landlord may, at Landlord’s election but following five (5) day’s prior written notice, pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title, and Tenant
shall immediately reimburse Landlord for the costs thereof as Additional Rent. 
 20.3 In the event that Tenant leases or finances the
acquisition of office equipment, furnishings, laboratory/research equipment, trade fixtures or other personal property utilized by Tenant in the operation of Tenant’s business (collectively, “Equipment”), Tenant warrants that
any Uniform Commercial Code financing statement executed by Tenant shall, upon its face or by exhibit thereto, indicate that such financing statement is applicable only to Equipment of Tenant located within the Premises. In no event shall the
address of the Building be furnished on a financing statement without qualifying language as to applicability of the lien only to Equipment located in an identified suite leased by Tenant. Should any holder of a financing statement authorized by
Tenant record or place of record a financing statement that appears to constitute a lien against any interest of Landlord in the real property or against equipment that may be located other than within an identified suite leased by Tenant, Tenant
shall, within ten (10) days after filing such financing statement, cause (a) a copy of the lender security agreement or other documents to which the financing statement pertains (subject to confidentiality requirements in such agreement or
other documents) to be furnished to Landlord to facilitate Landlord’s ability to demonstrate that the lien of such financing statement is not applicable to Landlord’s interest and (b) Tenant’s lender to amend such financing
statement and any other documents of record to clarify that any liens imposed thereby are not applicable to any interest of Landlord in the Premises, the Building or the Project. Notwithstanding anything to the contrary in this Lease, all
Tenant’s Personal Property and which may be moved without material damage to the Premises that is situated in or installed by Tenant in the Premises shall at all times remain Tenant’s property and Tenant may remove and replace any
Equipment at any time during the Term, provided that Tenant promptly repair any damage caused by the same. In no event shall Landlord have any common law or statutory lien or other security interest in any of Tenant’s Equipment, and Landlord
hereby expressly waives and releases any lien or security interest however created or arising. 
 21. Indemnification and
Exculpation. 
 21.1 Tenant agrees to indemnify, defend and save Landlord harmless from and against any and all demands, claims,
liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses (including, without limitation, reasonable attorneys’ fees, charges and disbursements) incurred in investigating or resisting the
same (collectively, “Claims”) arising from injury or death to any person or damage to any property occurring within or about the Premises, the Building or the Property arising directly or indirectly out of Tenant’s or
Tenant’s employees’, agents’ or guests’ use or occupancy of the Premises or a breach or default by Tenant in the performance of any of its obligations hereunder except to the extent

  
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caused by Landlord’s breach of Lease, willful misconduct or gross negligence. Subject to Section 21.2, Landlord agrees to indemnify, defend and save Tenant harmless from and
against any and all Claims arising from injury or death to any person or damage to any property occurring within or about the Premises, the Building or the Property to the extent that the same arise directly or indirectly out of the breach of Lease,
willful misconduct or gross negligence of Landlord or Landlord’s employees, agents or guests, except to the extent caused by Tenant’s breach of Lease, willful misconduct or negligence. 

21.2 Notwithstanding any provision of Section 21.1 to the contrary, Landlord shall not be liable to Tenant for, and Tenant assumes
all risk of, damage to personal property or scientific research, including, without limitation, loss of records kept by Tenant within the Premises and damage or losses caused by fire, electrical malfunction, gas explosion or water damage of any type
(including, without limitation, broken water lines, malfunctioning fire sprinkler systems, roof leaks or stoppages of lines), except to the extent that any such loss is due to Landlord’s gross negligence or willful disregard of written notice
by Tenant of need for a repair that Landlord is responsible to make for an unreasonable period of time. Tenant further waives any claim for injury to its business or loss of income relating to any such damage or destruction of personal property as
described in this Section 21.2. 
 21.3 Landlord shall not be liable for any damages arising from any act, omission or neglect
of any other tenant in the Building or the Project, or of any other third party. 
 21.4 Tenant acknowledges that security devices and
services, if any, while intended to deter crime, may not in given instances prevent theft or other criminal acts. Landlord shall not be liable for injuries or losses caused by criminal acts of third parties, and Tenant assumes the risk that any
security device or service may malfunction or otherwise be circumvented by a criminal. If Tenant desires protection against such criminal acts, then Tenant shall, at Tenant’s sole cost and expense, obtain appropriate insurance coverage. 

21.5 The provisions of this Article 21 shall survive the expiration or earlier termination of this Lease. 

21.6 The indemnity from Tenant in this Article 21 is intended to specifically cover actions brought by Tenant’s own employees, with
respect to acts or omissions during the term of this Lease. In that regard, with respect to Landlord, Tenant waives any immunity it may have under Washington’s Industrial Insurance Act, RCW Title 51, to the extent necessary to provide
Landlord with a full and complete indemnity from claims made by Tenant and its employees, to the extent of their negligence. If losses, liabilities, damages, liens, costs and expenses covered by Tenant’s indemnity are caused by the sole
negligence Landlord or by the concurrent negligence of both Landlord and Tenant, or their respective employees, agents, invitees and licensees, then Tenant shall indemnify Landlord only to the extent of Tenant’s own negligence or that of its
officers, agents, employees, guests or invitees. LANDLORD AND TENANT ACKNOWLEDGE THAT THE INDEMNIFICATION PROVISIONS OF THIS ARTICLE 21 WERE SPECIFICALLY NEGOTIATED AND AGREED UPON BY THEM. 

  
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 22. Insurance; Waiver of Subrogation. 

22.1 Landlord shall maintain insurance for the Building and the Project, including the Tenant Improvements, in amounts equal to full
replacement cost (exclusive of the costs of excavation, foundations and footings, and without reference to depreciation taken by Landlord upon its books or tax returns) or such lesser coverage as Landlord may elect, provided that the
deductibles for such insurance coverage shall be commercially reasonable; and provided further that the limits of such coverage shall not be less than ninety percent (90%) of such full replacement cost or the amount of such
insurance Landlord’s lender, mortgagee or beneficiary (each, a “Lender”), if any, requires Landlord to maintain, providing protection against any peril generally included within Special Form property insurance. Landlord,
subject to availability thereof, shall further insure, if Landlord deems it appropriate, coverage against flood, environmental hazard, earthquake, loss or failure of building equipment, rental loss during the period of repairs or rebuilding,
workmen’s compensation insurance and fidelity bonds for employees employed to perform services. Notwithstanding the foregoing, Landlord may, but shall not be deemed required to, provide insurance for any improvements installed by Tenant or that
are in addition to the Tenant Improvements, without regard to whether or not such are made a part of or are affixed to the Building. Any costs incurred by Landlord pursuant to this Section 22.1 shall constitute a portion of Operating
Expenses. 
 22.2 In addition, Landlord shall carry commercial general liability insurance with a single limit of not less than One Million
Dollars ($1,000,000) for death or bodily injury, or property damage with respect to the Project. Any costs incurred by Landlord pursuant to this Section 22.2 shall constitute a portion of Operating Expenses. 

22.3 Tenant shall, at its own cost and expense, procure and maintain in effect, beginning on the Term Commencement Date or the date of
occupancy, whichever occurs first, and continuing throughout the Term (and occupancy by Tenant, if any, after termination of this Lease) commercial general liability insurance with limits of not less than One Million Dollars ($1,000,000) per
occurrence and Two Million Dollars ($2,000,0000) general aggregate for death or bodily injury and property damage with respect to the Premises (including $100,000 fire legal liability (each loss)). 

22.4 The liability insurance required to be purchased and maintained by Tenant pursuant to this Lease shall name Landlord, BioMed Realty,
L.P., BioMed Realty Trust, Inc., Landlord’s constituent partners and the Building Lenders (if disclosed by Landlord to Tenant in writing) (“Landlord Parties”) as additional insureds. All insurance carried by either Landlord or
Tenant as required under this Lease shall be with companies having a rating of not less than policyholder rating of A- and financial category rating of at least Class VII in “Best’s Insurance
Guide.” Tenant shall obtain for Landlord from the insurance companies or cause the insurance companies to furnish certificates of coverage to Landlord. No such policy shall be cancelable or subject to reduction of coverage or other modification
or cancellation except after thirty (30) days’ prior written notice to Landlord from the insurer (except in the event of non-payment of premium, in which case ten (10) days written notice shall
be given). All such policies shall be written as primary 

  
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policies, not contributing with and not in excess of the coverage that Landlord may carry. Tenant’s policy may be a “blanket policy” that specifically provides that the amount of
insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, prior to the expiration of such policies, furnish Landlord with renewals or binders. Tenant agrees that if Tenant does not take out and maintain such insurance,
Landlord may (but shall not be required to) procure said insurance on Tenant’s behalf and at its cost to be paid by Tenant as Additional Rent. 

22.5 Tenant assumes the risk of damage to any fixtures, goods, inventory, merchandise, equipment and leasehold improvements, and Landlord
shall not be liable for injury to Tenant’s business or any loss of income therefrom, relative to such damage, all as more particularly set forth within this Lease. Tenant shall, at Tenant’s sole cost and expense, carry such insurance as
Tenant desires for Tenant’s protection with respect to personal property of Tenant or business interruption. 
 22.6 In each instance
where insurance is to name Landlord Parties as additional insureds, Tenant shall, upon Landlord’s written request, also designate and furnish certificates evidencing such Landlord Parties as additional insureds to (a) any Lender of
Landlord holding a security interest in the Building or the Project, (b) the landlord under any lease whereunder Landlord is a tenant of the real property upon which the Building is located if the interest of Landlord is or shall become that of
a tenant under a ground lease rather than that of a fee owner, and (c) any management company retained by Landlord to manage the Project. 

22.7 Landlord and Tenant each hereby waive any and all rights of recovery against the other or against the officers, directors, employees,
agents and representatives of the other on account of loss or damage occasioned by such waiving party or its property or the property of others under such waiving party’s control, in each case to the extent that such loss or damage is insured
against under any Special Form insurance policy that either Landlord or Tenant may have in force at the time of such loss or damage or are required to carry by this Lease, whichever is greater. Landlord and Tenant, upon obtaining the policies of
insurance required or permitted under this Lease, shall give notice to the insurance carrier or carriers that the foregoing mutual waiver of subrogation is contained in this Lease. If the release of either Landlord or Tenant, as set forth in the
first sentence of this Section 22.7, shall contravene Applicable Laws, then the liability of the party in question shall be deemed not released but shall be secondary to the other party’s insurer. 

22.8 Landlord may require insurance policy limits required under this Lease to be raised to conform with reasonable requirements of
Landlord’s Lender or, following the initial Term, to bring coverage limits to levels then being required of new tenants within the Project. 

23. Damage or Destruction. 

23.1 In the event of a partial destruction of the Building or the Project by fire or other perils covered by extended coverage insurance not
exceeding twenty-five percent (25%) of the full insurable value thereof, and provided that (a) the damage thereto is such that the Building or the Project may be repaired, reconstructed or restored within a period of twelve
(12) months from the date of the happening of such casualty and (b) Landlord shall receive insurance proceeds sufficient 

  
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to cover the cost of such repairs (except for any deductible amount provided by Landlord’s policy, which deductible amount, if paid by Landlord, shall constitute an Operating Expense),
Landlord shall commence and proceed diligently with the work of repair, reconstruction and restoration of the Building or the Project, as applicable, and this Lease shall continue in full force and effect. 

23.2 In the event of any damage to or destruction of the Building or the Project other than as described in Section 23.1, Landlord
may elect to repair, reconstruct and restore the Building or the Project, as applicable, in which case this Lease shall continue in full force and effect. If Landlord elects not to repair the Building or the Project, as applicable, then this Lease
shall terminate as of the date of such damage or destruction. 
 23.3 Landlord shall give written notice to Tenant within sixty
(60) days following the date of damage or destruction of its election whether to repair, reconstruct or restore the Building or the Project, as applicable, and in such notice, Landlord shall indicate Landlord’s good faith estimate of the
time to complete such repairs. If the expected time to complete repairs exceeds twelve (12) months, then Tenant may terminate this Lease upon written notice given to Landlord within thirty (30) days after receipt of Landlord’s notice.

 23.4 Upon any termination of this Lease under any of the provisions of this Article 23, the parties shall be released thereby
without further obligation to the other from the date possession of the Premises is surrendered to Landlord, except with regard to (a) items occurring prior to the damage or destruction and (b) provisions of this Lease that, by their
express terms, survive the expiration or earlier termination hereof. All property insurance proceeds (except with respect to Tenant’s personal property and removable equipment that Tenant purchased without any contribution from Landlord) shall
be paid to Landlord. 
 23.5 In the event of repair, reconstruction and restoration as provided in this Article 23, all Rent to
be paid by Tenant under this Lease shall be abated proportionately based on the extent to which Tenant’s use of the Premises is impaired during the period of such repair, reconstruction or restoration, unless Landlord at its sole cost provides
Tenant with other space during the period of repair that, in Tenant’s reasonable opinion, is suitable for the temporary conduct of Tenant’s business; provided, however, that the amount of such abatement shall be reduced by the
proceeds of business interruption insurance actually received by Tenant with respect to the Premises. 
 23.6 Notwithstanding anything to
the contrary contained in this Article 23, should Landlord be delayed or prevented from completing the repair, reconstruction or restoration of the damage or destruction to the Premises after the occurrence of such damage or destruction
by Force Majeure, then the time for Landlord to commence or complete repairs shall be extended on a day-for-day basis. 

23.7 If Landlord is obligated to or elects to repair, reconstruct or restore as herein provided, then Landlord shall be obligated to make such
repair, reconstruction or restoration only with regard to those portions of the Premises, the Building or the Property that were originally provided at Landlord’s expense. The repair, reconstruction or restoration of improvements not originally
provided by Landlord or at Landlord’s expense shall be the obligation of Tenant. In the 

  
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event Tenant has elected to upgrade certain improvements from the Building Standard, Landlord shall, upon the need for replacement due to an insured loss, provide only the Building Standard
(except with respect to improvements paid for out of the TI Allowance), unless Tenant again elects to upgrade such improvements and pay any incremental costs related thereto, except to the extent that excess insurance proceeds, if received, are
adequate to provide such upgrades, in addition to providing for basic repair, reconstruction and restoration of the Premises, the Building and the Project. 

23.8 Notwithstanding anything to the contrary contained in this Article 23, Landlord shall not have any obligation whatsoever to
repair, reconstruct or restore the Premises if the damage resulting from any casualty covered under this Article 23 occurs during the last twelve (12) months of the Term or any extension hereof, or to the extent that insurance
proceeds are not available therefor (provided Landlord carried insurance required under this Lease). Furthermore, if the damage resulting from any casualty covered under this Article 23 occurs during the last twelve (12) months of
the Term or any extension hereof, Tenant shall be entitled to terminate this Lease upon written notice to Landlord. 
 23.9 Landlord’s
obligation, should it elect or be obligated to repair or rebuild, shall be limited to the Property and the Building; provided that Tenant shall, at its expense, replace or fully repair all of Tenant’s personal property and any
Alterations installed by Tenant existing at the time of such damage or destruction. If the Property or the Building is to be repaired in accordance with the foregoing, Landlord shall make available to Tenant any portion of insurance proceeds it
receives that are allocable to the Alterations constructed by Tenant pursuant to this Lease, provided Tenant is not then in default beyond applicable notice and cure periods under this Lease. 

24. Eminent Domain. 

24.1 In the event the whole of the Premises, or such part thereof as shall substantially interfere with Tenant’s use and occupancy
thereof, shall be taken for any public or quasi-public purpose by any lawful power or authority by exercise of the right of appropriation, condemnation or eminent domain, or sold to prevent such taking, Tenant or Landlord may terminate this Lease
effective as of the date possession is required to be surrendered to said authority. 
 24.2 In the event of a partial taking of the
Building or the Project, or of drives, walkways or parking areas serving the Building or the Project for any public or quasi-public purpose by any lawful power or authority by exercise of right of appropriation, condemnation, or eminent domain, or
sold to prevent such taking, then, without regard to whether any portion of the Premises occupied by Tenant was so taken, Landlord may elect to terminate this Lease as of such taking if such taking is, in Landlord’s reasonable opinion, of a
material nature such as to make it uneconomical to continue use of the unappropriated portion for purposes of renting office or laboratory space. 

24.3 Tenant shall be entitled to any award that is specifically awarded as compensation for (a) the taking of Tenant’s personal
property that was installed solely at Tenant’s expense and (b) the costs of Tenant moving to a new location. Except as set forth in the previous sentence, any award for such taking shall be the property of Landlord. 

  
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 24.4 If, upon any taking of the nature described in this Article 24, this Lease
continues in effect, then Landlord shall promptly proceed to restore the Premises, the Building and the Project, as applicable, to substantially their same condition prior to such partial taking to the extent such restoration is feasible, as
determined by Landlord in its sole and absolute discretion. The Rent shall be decreased proportionately to reflect the loss of any portion of the Premises no longer available to Tenant. 

25. Defaults and Remedies. 

25.1 Late payment by Tenant to Landlord of Rent and other sums due shall cause Landlord to incur costs not contemplated by this Lease, the
exact amount of which shall be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges that may be imposed on Landlord by the terms of any mortgage or trust
deed covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within three (3) business days after Tenant’s receipt of written notice from Landlord regarding such overdue amount (provided
that Tenant shall only be entitled to one (1) such written notice in a consecutive twelve (12) month period), Tenant shall pay to Landlord an additional sum of five percent (5%) of the overdue Rent as a late charge. The parties agree
that this late charge represents a fair and reasonable estimate of the costs that Landlord shall incur by reason of late payment by Tenant. 

25.2 No payment by Tenant or receipt by Landlord of a lesser amount than the Rent payment herein stipulated shall be deemed to be other than
on account of the Rent, nor shall any endorsement or statement on any check or any letter accompanying any check or payment as Rent be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to
Landlord’s right to recover the balance of such Rent or pursue any other remedy provided in this Lease or in equity or at law. If a dispute shall arise as to any amount or sum of money to be paid by Tenant to Landlord hereunder, Tenant shall
have the right to make payment “under protest,” such payment shall not be regarded as a voluntary payment, and there shall survive the right on the part of Tenant to institute suit for recovery of the payment paid under protest. 

25.3 If Tenant fails to pay any sum of money required to be paid by it hereunder, or shall fail to perform any other act on its part to be
performed hereunder, Landlord may, without waiving or releasing Tenant from any obligations of Tenant, but shall not be obligated to, make such payment or perform such act; provided that such failure by Tenant continues for three
(3) days after Landlord delivers notice to Tenant demanding performance by Tenant; or provided that such failure by Tenant unreasonably interfered with the use of the Building by any other tenant or with the efficient operation of the
Building, or resulted or could have resulted in a violation of Applicable Laws or the cancellation of an insurance policy maintained by Landlord. Notwithstanding the foregoing, in the event of an emergency, Landlord shall have the right to enter the
Premises and act in accordance with its rights as provided elsewhere in this Lease. In addition to the late charge described in Section 25.1, Tenant shall pay to Landlord as Additional Rent all sums so paid or

  
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incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal to twelve percent (12%) per annum or the highest rate permitted
by Applicable Laws, whichever is less. 
 25.4 The occurrence of any one or more of the following events shall constitute a
“Default” hereunder by Tenant: 
 (a) The vacation of the Premises by Tenant without the intention to continue to perform
obligations; 
 (b) The failure by Tenant to make any payment of Rent, as and when due, where such failure shall continue for a period of
three (3) business days after Tenant’s receipt of written notice thereof from Landlord; 
 (c) The failure by Tenant to observe
or perform any obligation or covenant contained herein (other than described in Subsection 25.4(a)) to be performed by Tenant, where such failure shall continue for a period of thirty (30) days after written notice thereof from
Landlord to Tenant; provided that, if the nature of Tenant’s default is such that it reasonably requires more than thirty (30) days to cure, Tenant shall not be deemed to be in default if Tenant shall commence such cure within said
thirty (30) day period and thereafter diligently prosecute the same to completion; 
 (d) Tenant makes an assignment for the benefit
of creditors; 
 (e) A receiver, trustee or custodian is appointed to or does take title, possession or control of all or substantially all
of Tenant’s assets; 
 (f) Tenant files a voluntary petition under the United States Bankruptcy Code or any successor statute (the
“Bankruptcy Code”); 
 (g) Any involuntary petition if filed against Tenant under any chapter of the Bankruptcy Code and
is not dismissed within one hundred twenty (120) days; 
 (h) The failure by Tenant to deliver an estoppel certificate in accordance
with Article 30 where such failure shall continue for a period of three (3) business days after Tenant’s receipt of written notice thereof from Landlord; 

(i) The failure by Tenant to subordinate its interest under this Lease in accordance with Section 35.3 hereof where such failure
shall continue for a period of three (3) business days after Tenant’s receipt of written notice thereof from Landlord; and 
 (j)
Tenant’s interest in this Lease is attached, executed upon or otherwise judicially seized and such action is not released within one hundred twenty (120) days of the action. 

  
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 Notices given under this Section 25.4 shall specify the alleged default and shall
demand that Tenant perform the provisions of this Lease or pay the Rent that is in arrears, as the case may be, within the applicable period of time, or quit the Premises. No such notice shall be deemed a forfeiture or a termination of this Lease
unless Landlord elects otherwise in such notice. The foregoing notice and cure provisions shall be inclusive of and not in addition to the notices and cure periods provided for in RCW 59.12, as now or hereafter amended, or any legislation in lieu or
substitution thereof. 
 25.5 In the event of a Default by Tenant, and at any time thereafter, with or without notice or demand and without
limiting Landlord in the exercise of any right or remedy that Landlord may have, Landlord shall be entitled to terminate Tenant’s right to possession of the Premises by any lawful means, in which case this Lease shall terminate and Tenant shall
immediately surrender possession of the Premises to Landlord. In such event, Landlord shall have the immediate right to re-enter and remove all persons and property, and such property may be removed and stored
in a public warehouse or elsewhere at the cost and for the account of Tenant, all without service of notice or resort to legal process and without being deemed guilty of trespass or becoming liable for any loss or damage that may be occasioned
thereby, except to the extent of Landlord’s gross negligence or intentional misconduct. In the event that Landlord shall elect to so terminate this Lease, then Landlord shall be entitled to recover from Tenant all damages incurred by Landlord
by reason of Tenant’s default, including, without limitation: 
 (a) The worth at the time of award of any unpaid Rent that had
accrued at the time of such termination; plus 
 (b) The worth at the time of award of the amount by which the unpaid Rent that would have
accrued during the period commencing with termination of the Lease and ending at the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord’s reasonable satisfaction
could have been reasonably avoided; plus 
 (c) The worth at the time of award of the amount by which the unpaid Rent for the balance of
the Term after the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord’s reasonable satisfaction could have been reasonably avoided; plus 

(d) Any other amount necessary to compensate Landlord for all the detriment caused by Tenant’s failure to perform its obligations under
this Lease or that in the ordinary course of things would be likely to result therefrom, including, without limitation, the cost of restoring the Premises to the condition required under the terms of this Lease; plus 

(e) At Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by
Applicable Laws. 
 As used in Subsections 25.5(a) and 25.5(b), “worth at the time of award” shall be computed by allowing
interest at the rate specified in Section 25.1. As used in Subsection 25.5(c) above, the 

  
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“worth at the time of the award” shall be computed by taking the present value of such amount, using the discount rate of the Federal Reserve Bank of San Francisco at the time of the
award plus one (1) percentage point. 
 25.6 In addition to any other remedies available to Landlord at law or in equity and under this
Lease, Landlord may continue this Lease in effect after Tenant’s Default and abandonment and recover Rent as it becomes due, provided Tenant has the right to sublet or assign, subject only to reasonable limitations). In addition,
Landlord shall not be liable in any way whatsoever for its failure or refusal to relet the Premises. For purposes of this Section 25.6, the following acts by Landlord will not constitute the termination of Tenant’s right to
possession of the Premises: 
 (a) Acts of maintenance or preservation or efforts to relet the Premises, including, but not limited to,
alterations, remodeling, redecorating, repairs, replacements or painting as Landlord shall consider advisable for the purpose of reletting the Premises or any part thereof; or 

(b) The appointment of a receiver upon the initiative of Landlord to protect Landlord’s interest under this Lease or in the Premises.

 Notwithstanding the foregoing, in the event of a Default by Tenant, Landlord may elect at any time to terminate this Lease and to recover damages to
which Landlord is entitled. If Landlord does not elect to terminate this Lease as provided in Section 25.5, then Landlord may, from time to time, recover all Rent as it becomes due under this Lease. 

25.7 In the event Landlord elects to terminate this Lease and relet the Premises, Landlord may execute any new lease in its own name. Tenant
hereunder shall have no right or authority whatsoever to collect any Rent from such tenant. The proceeds of any such reletting shall be applied as follows: 

(a) First, to the payment of any indebtedness other than Rent due hereunder from Tenant to Landlord, including, without limitation, storage
charges or brokerage commissions owing from Tenant to Landlord as the result of such reletting; 
 (b) Second, to the payment of the costs
and expenses of reletting the Premises, including (i) alterations and repairs that Landlord deems reasonably necessary and advisable and (ii) reasonable attorneys’ fees, charges and disbursements incurred by Landlord in connection
with the retaking of the Premises and such reletting; 
 (c) Third, to the payment of Rent and other charges due and unpaid hereunder; and

 (d) Fourth, to the payment of future Rent and other damages payable by Tenant under this Lease. 

  
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 25.8 All of Landlord’s rights, options and remedies hereunder shall be construed and held to
be nonexclusive and cumulative. Landlord shall have the right to pursue any one or all of such remedies, or any other remedy or relief that may be provided by Applicable Laws, whether or not stated in this Lease. No waiver of any default of Tenant
hereunder shall be implied from any acceptance by Landlord of any Rent or other payments due hereunder or any omission by Landlord to take any action on account of such default if such default persists or is repeated, and no express waiver shall
affect defaults other than as specified in said waiver. 
 25.9 Landlord’s termination of (a) this Lease or (b) Tenant’s
right to possession of the Premises shall not relieve Tenant of any liability to Landlord that has previously accrued or that shall arise based upon events that occurred prior to the later to occur of (i) the date of Lease termination or
(ii) the date Tenant surrenders possession of the Premises. 
 25.10 To the extent permitted by Applicable Laws, Tenant waives any and
all rights of redemption granted by or under any present or future Applicable Laws if Tenant is evicted or dispossessed for any cause, or if Landlord obtains possession of the Premises due to Tenant’s default hereunder or otherwise. 

25.11 Landlord shall not be in default under this Lease unless Landlord fails to perform obligations required of Landlord within a reasonable
time, but in no event shall such failure continue for more than thirty (30) days after written notice from Tenant specifying the nature of Landlord’s failure; provided, however, that if the nature of Landlord’s
obligation is such that more than thirty (30) days are required for its performance, then Landlord shall not be in default if Landlord commences performance within such thirty (30) day period and thereafter diligently prosecutes the same
to completion. 
 25.12 In the event of any default by Landlord, Tenant shall give notice by registered or certified mail to any
(a) beneficiary of a deed of trust or (b) mortgagee under a mortgage covering the Premises, the Building or the Project and to any landlord of any lease of land upon or within which the Premises, the Building or the Project is located, and
shall offer such beneficiary, mortgagee or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Building by power of sale or a judicial action if such should prove necessary to effect a cure;
provided that Landlord shall furnish to Tenant in writing the names and addresses of all such persons who are to receive such notices. 

26. Assignment or Subletting. 

26.1 Except as hereinafter expressly permitted, Tenant shall not, either voluntarily or by operation of Applicable Laws, directly or
indirectly sell, hypothecate, assign, pledge, encumber or otherwise transfer this Lease, or sublet the Premises (each, a “Transfer”), without Landlord’s prior written consent, which consent Landlord may not unreasonably
withhold, condition or delay. Tenant shall have the right to Transfer without Landlord’s prior written consent the Lease or any portion thereof or the Premises or any part thereof to any person or entity that as of the date of determination and
at all times thereafter directly, or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with Tenant, to any entity resulting from the 

  
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merger, consolidation, acquisition or restructuring of Tenant, or to the purchaser in connection with the sale of substantially all of the assets used in connection with the business operated by
Tenant at the Building (“Tenant’s Affiliate”), provided Tenant shall notify Landlord in writing at least thirty (30) days prior to the effectiveness of such Transfer to Tenant’s Affiliate (an “Exempt
Transfer”) and otherwise comply with the requirements of this Lease regarding such Transfer. For purposes of Exempt Transfers, “control” requires both (a) owning (directly or indirectly) more than fifty percent (50%) of
the stock or other equity interests of another person and (b) possessing, directly or indirectly, the power to direct or cause the direction of the management and policies of such person. Notwithstanding anything to the contrary, the following
Sections 26.2, 26.3 and 26.9 of the Lease shall not be applicable to any Exempt Transfer. 
 26.2 In the event
Tenant desires to effect a Transfer, then, at least forty-five (45) but not more than ninety (90) days prior to the date when Tenant desires the assignment or sublease to be effective (the “Transfer Date”), Tenant shall
provide written notice to Landlord (the “Transfer Notice”) containing information (including references) concerning the character of the proposed transferee, assignee or sublessee; the Transfer Date; any ownership or commercial
relationship between Tenant and the proposed transferee, assignee or sublessee; and the consideration and all other material terms and conditions of the proposed Transfer, all in such detail as Landlord shall reasonably require. Tenant shall also
tender to Landlord reasonable attorney’s fees and other costs or overhead expenses incurred by Landlord in reviewing Tenant’s request for such Transfer (not to exceed $3,000). 

26.3 Landlord, in determining whether consent should be given to a proposed Transfer, may give consideration to (a) the financial
strength of such transferee, assignee or sublessee (notwithstanding Tenant remaining liable for Tenant’s performance), (b) any change in use that such transferee, assignee or sublessee proposes to make in the use of the Premises and
(c) Landlord’s desire to exercise its rights under Section 26.9 to cancel this Lease. 
 26.4 In no event shall
Landlord be deemed to be unreasonable for declining to consent to a Transfer to a transferee, assignee or sublessee of poor reputation, lacking financial qualifications or seeking a change in the Permitted Use, or jeopardizing directly or indirectly
the status of Landlord or any of Landlord’s affiliates as a Real Estate Investment Trust under the Internal Revenue Code of 1986. Notwithstanding anything contained in this Lease to the contrary, (w) no Transfer shall be consummated on any
basis such that the rental or other amounts to be paid by the occupant, assignee, manager or other transferee thereunder would be based, in whole or in part, on the income or profits derived by the business activities of such occupant, assignee,
manager or other transferee; (x) Tenant shall not furnish or render any services to an occupant, assignee, manager or other transferee with respect to whom transfer consideration is required to be paid, or manage or operate the Premises or any
capital additions so transferred, with respect to which transfer consideration is being paid; (y) Tenant shall not consummate a Transfer with any person in which Landlord owns an interest, directly or indirectly (by applying constructive
ownership rules set forth in Section 856(d)(5) of the Internal Revenue Code (“Revenue Code”); and (z) Tenant shall not consummate a Transfer with any person or in any manner that could cause any portion of the amounts
received by Landlord pursuant to this Lease or any sublease, license or other arrangement 

  
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for the right to use, occupy or possess any portion of the Premises to fail to qualify as “rents from real property” within the meaning of Section 856(d) of the Revenue Code, or
any similar or successor provision thereto or which could cause any other income of Landlord to fail to qualify as income described in Section 856(c)(2) of the Revenue Code. 

26.5 As conditions precedent to Tenant subleasing the Premises or to Landlord considering a request by Tenant to Tenant’s transfer of
rights or sharing of the Premises, Landlord may require any or all of the following: 
 (a) Tenant shall remain fully liable under this
Lease during the unexpired Term; 
 (b) Tenant shall provide Landlord with evidence reasonably satisfactory to Landlord that the value of
Landlord’s interest under this Lease shall not be diminished or reduced by the proposed Transfer. Such evidence shall include, without limitation, evidence respecting the relevant business experience and financial responsibility and status of
the proposed transferee, assignee or sublessee; 
 (c) If Tenant’s transfer of rights or sharing of the Premises provides for the
receipt by, on behalf of or on account of Tenant of any consideration of any kind whatsoever (including, without limitation, a premium rental for a sublease or lump sum payment for an assignment, but excluding Tenant’s reasonable costs in
marketing and subleasing the Premises) in excess of the rental and other charges due to Landlord under this Lease, Tenant shall pay fifty percent (50%) of all of such excess to Landlord, provided that Tenant may first recover transaction costs
incurred by Tenant, including marketing expenses, tenant improvement allowances actually provided by Tenant, construction costs, alterations, cash concessions, brokerage commissions, attorneys’ fees and free rent. If said consideration consists
of cash paid to Tenant, payment to Landlord shall be made upon receipt by Tenant of such cash payment; 
 (d) The proposed transferee,
assignee or sublessee shall agree that, in the event Landlord gives such proposed transferee, assignee or sublessee notice that Tenant is in default under this Lease, such proposed transferee, assignee or sublessee shall thereafter make all payments
otherwise due Tenant directly to Landlord, which payments shall be received by Landlord without any liability being incurred by Landlord, except to credit such payment against those due by Tenant under this Lease, and any such proposed transferee,
assignee or sublessee shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however, that in no event shall Landlord or its Lenders, successors or assigns be obligated
to accept such attornment; 
 (e) Landlord’s consent to any such Transfer shall be effected on Landlord’s forms; 

(f) Tenant shall not then be in default beyond applicable notice and cure periods hereunder in any respect; 

  
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 (g) Such proposed transferee, assignee or sublessee’s use of the Premises shall be the same
as the Permitted Use; 
 (h) Landlord shall not be bound by any provision of any agreement pertaining to the Transfer, except for
Landlord’s written consent to the same; 
 (i) Tenant shall pay all transfer and other taxes (including interest and penalties)
assessed or payable for any Transfer; 
 (j) Landlord’s consent (or waiver of its rights) for any Transfer shall not waive
Landlord’s right to consent to any later Transfer; 
 (k) Tenant shall deliver to Landlord one executed copy of any and all written
instruments evidencing or relating to the Transfer; and 
 (l) A list of Hazardous Materials (as defined in Section 40.8
below), certified by the proposed transferee, assignee or sublessee to be true and correct, that the proposed transferee, assignee or sublessee intends to use or store in the Premises. Additionally, Tenant shall deliver to Landlord, on or before the
date any proposed transferee, assignee or sublessee takes occupancy of the Premises, all of the items relating to Hazardous Materials of such proposed transferee, assignee or sublessee as described in Section 40.2. 

26.6 Any Transfer that is not in compliance with the provisions of this Article 26 shall be void and shall, at the option of
Landlord, terminate this Lease. 
 26.7 The consent by Landlord to a Transfer shall not relieve Tenant or proposed transferee, assignee or
sublessee from obtaining Landlord’s consent to any further Transfer, nor shall it release Tenant or any proposed transferee, assignee or sublessee of Tenant from full and primary liability under this Lease. 

26.8 Notwithstanding any Transfer, Tenant shall remain fully and primarily liable for the payment of all Rent and other sums due or to become
due hereunder, and for the full performance of all other terms, conditions and covenants to be kept and performed by Tenant. The acceptance of Rent or any other sum due hereunder, or the acceptance of performance of any other term, covenant or
condition thereof, from any person or entity other than Tenant shall not be deemed a waiver of any of the provisions of this Lease or a consent to any Transfer. 

26.9 If Tenant delivers to Landlord a Transfer Notice indicating a desire to assign the Lease or otherwise Transfer this Lease or all or
substantially all of the Premises to a proposed transferee, assignee or sublessee for all or substantially all of the Term (other than an Exempt Transfer), then Landlord shall have the option, exercisable by giving notice to Tenant at any time
within ten (10) days after Landlord’s receipt of such Transfer Notice, to terminate this Lease as of the date specified in the Transfer Notice as the Transfer Date, except for those provisions that, by their express terms, survive the
expiration or earlier termination hereof. For purposes of the preceding sentence, “substantially all of the Term” shall mean that the proposed transfer would 

  
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expire during the last one (1) year of the Term. If Landlord exercises such option, then Tenant shall have the right to withdraw such Transfer Notice by delivering to Landlord written notice
of such election within five (5) days after Landlord’s delivery of notice electing to exercise Landlord’s option to terminate this Lease. In the event Tenant withdraws the Transfer Notice as provided in this Section 26.8,
this Lease shall continue in full force and effect. No failure of Landlord to exercise its option to terminate this Lease shall be deemed to be Landlord’s consent to a proposed Transfer. 

26.10 If Tenant sublets the Premises or any portion thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for
Tenant’s obligations under this Lease, all rent from any such subletting, and appoints Landlord as assignee for Tenant, and Landlord (or a receiver for Tenant appointed on Landlord’s application) may collect such rent and apply it toward
Tenant’s obligations under this Lease; provided that, until the occurrence of a Default by Tenant, Tenant shall have the right to collect such rent. 

27. Attorneys’ Fees. If either party commences an action against the other party arising out of or in connection with this Lease,
then the substantially prevailing party shall be entitled to have and recover from the other party reasonable attorneys’ fees, charges and disbursements and costs of suit. 

28. Bankruptcy. In the event a debtor, trustee or debtor in possession under the Bankruptcy Code, or another person with similar
rights, duties and powers under any other Applicable Laws, proposes to cure any default under this Lease or to assume or assign this Lease and is obliged to provide adequate assurance to Landlord that (a) a default shall be cured,
(b) Landlord shall be compensated for its damages arising from any breach of this Lease and (c) future performance of Tenant’s obligations under this Lease shall occur, then such adequate assurances shall include any or all of the
following, as designated by Landlord in its sole and absolute discretion: 
 28.1 Those acts specified in the Bankruptcy Code or other
Applicable Laws as included within the meaning of “adequate assurance,” even if this Lease does not concern a shopping center or other facility described in such Applicable Laws; 

28.2 A prompt cash payment to compensate Landlord for any monetary defaults or actual damages arising directly from a breach of this Lease;

 28.3 A cash deposit in an amount at least equal to the then-current amount of the Security Deposit; or 

28.4 The assumption or assignment of all of Tenant’s interest and obligations under this Lease. 

29. Definition of Landlord. With regard to obligations imposed upon Landlord pursuant to this Lease, the term
“Landlord,” as used in this Lease, shall refer only to Landlord or Landlord’s then-current successor-in-interest. In the event of any transfer,
assignment or conveyance of Landlord’s interest in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as 

  
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applicable, Landlord herein named (and in case of any subsequent transfers or conveyances, the subsequent Landlord) shall be automatically freed and relieved, from and after the date of such
transfer, assignment or conveyance, from all liability for the performance of any covenants or obligations contained in this Lease thereafter to be performed by Landlord (except for return of the Security if Landlord’s assignee does not assume
the obligation to repay the Security Deposit to Landlord) and, without further agreement, the transferee, assignee or conveyee of Landlord’s in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as applicable,
shall be deemed to have assumed and agreed to observe and perform any and all covenants and obligations of Landlord hereunder during the tenure of its interest in the Lease or the Property. Landlord or any subsequent Landlord may transfer its
interest in the Premises or this Lease without Tenant’s consent. 
 30. Estoppel Certificate. Tenant shall, within ten
(10) days of receipt of written notice from Landlord, execute, acknowledge and deliver a statement in writing substantially in the form attached to this Lease as Exhibit E, or on any other form reasonably requested by a proposed
Lender or purchaser, (a) certifying that this Lease is unmodified and in full force and effect (or, if modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to
which rental and other charges are paid in advance, if any, (b) acknowledging that there are not, to Tenant’s knowledge, any uncured defaults on the part of Landlord hereunder, or specifying such defaults if any are claimed, and
(c) setting forth such further reasonable information with respect to this Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any prospective purchaser or encumbrancer of all or any portion of the real
property of which the Premises are a part such that Tenant shall be stopped from arguing facts contrary to the express assertions of the estoppel. If Tenant fails to deliver such statement within such prescribed time, then such estoppel shall be
binding upon Tenant that the Lease is in full force and effect and without modification except as may be represented by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution. 

31. Joint and Several Obligations. If more than one person or entity executes this Lease as Tenant, then: 

31.1 Each of them is jointly and severally liable for the keeping, observing and performing of all of the terms, covenants, conditions,
provisions and agreements of this Lease to be kept, observed or performed by Tenant; and 
 31.2 The term “Tenant” as used
in this Lease shall mean and include each of them, jointly and severally. The act of, notice from, notice to, refund to, or signature of any one or more of them with respect to the tenancy under this Lease, including, without limitation, any
renewal, extension, expiration, termination or modification of this Lease, shall be binding upon each and all of the persons executing this Lease as Tenant with the same force and effect as if each and all of them had so acted, so given or received
such notice or refund, or so signed. 
 32. Limitation of Landlord’s Liability. 

32.1 If Landlord is in default under this Lease and, as a consequence, Tenant recovers a monetary judgment against Landlord, the judgment
shall be satisfied only out of (a) the 

  
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proceeds of sale received on execution of the judgment and levy against the right, title and interest of Landlord in the Building and the Project of which the Premises are a part, (b) rent,
insurance proceeds or other income from such real property receivable by Landlord or (c) the consideration received by Landlord from the sale, financing, refinancing or other disposition of all or any part of Landlord’s right, title or
interest in the Building or the Project of which the Premises are a part. 
 32.2 Landlord shall not be personally liable for any deficiency
under this Lease. If Landlord is a partnership or joint venture, then the partners of such partnership shall not be personally liable for Landlord’s obligations under this Lease, and no partner of Landlord shall be sued or named as a party in
any suit or action, and service of process shall not be made against any partner of Landlord except as may be necessary to secure jurisdiction of the partnership or joint venture. If Landlord is a corporation, then the shareholders, directors,
officers, employees and agents of such corporation shall not be personally liable for Landlord’s obligations under this Lease, and no shareholder, director, officer, employee or agent of Landlord shall be sued or named as a party in any suit or
action, and service of process shall not be made against any shareholder, director, officer, employee or agent of Landlord. If Landlord is a limited liability company, then the members of such limited liability company shall not be personally liable
for Landlord’s obligations under this Lease, and no member of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any member of Landlord except as may be necessary to secure
jurisdiction of the limited liability company. No partner, shareholder, director, employee, member or agent of Landlord shall be required to answer or otherwise plead to any service of process, and no judgment shall be taken or writ of execution
levied against any partner, shareholder, director, employee or agent of Landlord. 
 32.3 Each of the covenants and agreements of this
Article 32 shall be applicable to any covenant or agreement either expressly contained in this Lease or imposed by Applicable Laws and shall survive the expiration or earlier termination of this Lease. 

33. Project Control by Landlord. 

33.1 Landlord reserves full control over the Building and the Project to the extent not inconsistent with Tenant’s enjoyment of the
Premises as provided by this Lease. This reservation includes, without limitation, Landlord’s right to subdivide the Project, convert the Building to condominium units, grant easements and licenses to third parties, and maintain or establish
ownership of the Building separate from fee title to the Property. 
 33.2 Tenant shall, at Landlord’s request, promptly execute such
further reasonable documents as may be reasonably appropriate to assist Landlord in the performance of its obligations hereunder; provided that Tenant need not execute any document that creates additional liability for Tenant, that materially
adversely affects Tenant or that deprives Tenant of the quiet enjoyment and use of the Premises as provided by this Lease. 
 33.3 Landlord
may, at any and all reasonable times during non-business hours (or during business hours if Tenant so requests), and upon one (1) business day prior written or facsimile notice (provided that no
time restrictions shall apply or advance notice be required if an 

  
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emergency necessitates immediate entry), enter the Premises to (a) inspect the same and to determine whether Tenant is in compliance with its obligations hereunder, (b) supply any
service Landlord is required to provide hereunder, (c) show the Premises to prospective purchasers or tenants during the final year of the Term, (d) post notices of nonresponsibility, (e) access the telephone equipment, electrical
substation and fire risers and (f) alter, improve or repair any portion of the Building other than the Premises for which access to the Premises is reasonably necessary. For any such access to the Premises, Landlord shall, except in an
emergency, permit a representative of Tenant to accompany Landlord, and at all times agrees to comply with Tenant’s reasonable security and safety rules that are orally communicated to Landlord’s representative accessing the Premises at
the time or access and/or provided to Landlord in writing. In connection with any such alteration, improvement or repair as described in Subsection 33.3(f) above, Landlord may erect in the Premises or elsewhere in the Project scaffolding
and other structures reasonably required for the alteration, improvement or repair work to be performed. In no event shall Tenant’s Rent abate as a result of Landlord’s activities pursuant to this Section 33.3; provided,
however, that all such activities shall be conducted in such a manner so as to cause as little interference to Tenant as is reasonably possible. Landlord shall at all times retain a key with which to unlock all of the doors in the Premises.
If an emergency necessitates immediate access to the Premises, Landlord may use whatever force is necessary to enter the Premises, and any such entry to the Premises shall not constitute a forcible or unlawful entry to the Premises, a detainer of
the Premises, or an eviction of Tenant from the Premises or any portion thereof. 
 34. Quiet Enjoyment. So long as Tenant is not in
default beyond applicable notice and cure periods under this Lease, Landlord or anyone acting through or under Landlord shall not disturb Tenant’s occupancy of the Premises, except as permitted by this Lease. 

35. Subordination and Attornment. 

35.1 This Lease shall be subject and subordinate to the lien of any mortgage, deed of trust, or lease in which Landlord is tenant now or
hereafter in force against the Building or the Project (each an “Encumbrance”) and to all advances made or hereafter to be made upon the security thereof without the necessity of the execution and delivery of any further instruments on the
part of Tenant to effectuate such subordination, according to the following terms and conditions. 
 35.2 Landlord shall endeavor, no later
than twenty (20) days after the date of full execution of this Lease, to provide Tenant, without cost or charge, with commercially reasonable subordination, non-disturbance and attornment agreements
(“SNDA”) in favor of Tenant from any ground lessors, mortgage holders or lien holders (each, a “Superior Mortgagee”) then in existence. Without limitation, the SNDA shall provide that the Superior Mortgagee shall
recognize this Lease, and in the event of any default under such Encumbrance or any foreclosure action, forced sale, or other proceeding in connection therewith, the rights of Tenant under this Lease, and Tenant’s possession of the Premises
shall not be disturbed, Tenant shall not be named as defendant in any such proceedings, and that in the event such Superior Mortgagee becomes owner of the Premises, Building, Project or any part thereof, such holder shall accept Tenant as Tenant
under this Lease, and, notwithstanding the foregoing, any such SNDA shall include customary limitations on such 

  
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holder’s obligations to Tenant. Said SNDA shall be in recordable form and may be recorded at Tenant’s election and expense. In the event Landlord fails to provide such commercially
reasonable SNDA within the time frame set forth in this Section, Tenant shall have the right, as its sole and exclusive remedy, exercisable no later than thirty (30) days after the date of full execution of this Lease, to terminate this Lease
upon ten (10) business days written notice to Landlord. In the event Tenant elects to terminate this Lease and Landlord does not provide Tenant with the applicable SNDA within such ten (10) day period, this Lease shall terminate and
Landlord shall reimburse Tenant all of Tenant’s pre-paid rent. This provision shall survive the termination of this Lease. 

35.3 Notwithstanding the foregoing, Tenant’s subordination as provided above with respect to any Encumbrances arising after the date of
this Lease shall be conditioned upon Landlord providing Tenant with a commercially reasonable SNDA that without limitation complies with the preceding paragraph. Said SNDA shall be in recordable form and may be recorded at Tenant’s expense.

 35.4 Notwithstanding the foregoing, Tenant shall execute and deliver upon demand such further reasonable instrument or instruments
evidencing such subordination of this Lease to the lien of any such mortgage or mortgages or deeds of trust or lease in which Landlord is tenant as may be required by Landlord so long as the same are consistent with this Article 35.
However, if any such mortgagee, beneficiary or Landlord under lease wherein Landlord is tenant so elects, this Lease shall be deemed prior in lien to any such lease, mortgage, or deed of trust upon or including the Premises regardless of date and
Tenant shall execute a statement in writing to such effect at Landlord’s request. 
 35.5 Upon written request of Landlord and
opportunity for Tenant to review, Tenant agrees to execute any Lease amendments not materially altering the terms of this Lease, if required by a mortgagee or beneficiary of a deed of trust encumbering real property of which the Premises constitute
a part incident to the financing of the real property of which the Premises constitute a part. Any change materially affecting or changing Tenant’s use of the Premises, materially increasing Tenant’s costs or liabilities, affecting the
amount or timing of the consideration to be paid by Tenant or modifying the Term of this Lease shall be deemed as materially altering the terms hereof. 

35.6 In the event any proceedings are brought for foreclosure, or in the event of the exercise of the power of sale under any mortgage or deed
of trust made by Landlord covering the Premises, Tenant’s use and enjoyment of the Premises shall not be disturbed and Tenant shall attorn to the purchaser upon any such foreclosure or sale and recognize such purchaser as Landlord under this
Lease. 
 36. Surrender. 

36.1 At lease ten (10) days prior to Tenant’s surrender of possession of any part of the Premises, Tenant shall provide Landlord
with (a) a facility decommissioning and Hazardous Materials closure plan for the Premises (“Exit Survey”), and (b) written evidence of all appropriate governmental releases obtained by Tenant in accordance with Applicable
Laws, including, without 

  
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limitation, laws pertaining to the surrender of the Premises. In addition, Tenant agrees to remain responsible after the surrender of the Premises for the remediation of any recognized
environmental conditions set forth in the Exit Survey and compliance with any recommendations set forth in the Exit Survey. Tenant’s obligations under this Section 36.1 shall survive the expiration or earlier termination of the
Lease. 
 36.2 No surrender of possession of any part of the Premises shall release Tenant from any of its obligations hereunder, unless
such surrender is accepted in writing by Landlord. 
 36.3 The voluntary or other surrender of this Lease by Tenant shall not effect a
merger with Landlord’s fee title or leasehold interest in the Premises, the Building or the Property, unless Landlord consents in writing, and shall, at Landlord’s option, operate as an assignment to Landlord of any or all subleases. 

36.4 The voluntary or other surrender of any ground or other underlying lease that now exists or may hereafter be executed affecting the
Building or the Project, or a mutual cancellation thereof or of Landlord’s interest therein by Landlord and its lessor shall not effect a merger with Landlord’s fee title or leasehold interest in the Premises, the Building or the Property
and shall, at the option of the successor to Landlord’s interest in the Building or the Project, as applicable, operate as an assignment of this Lease. 

37. Waiver and Modification. No provision of this Lease may be modified, amended or supplemented except by an agreement in writing
signed by Landlord and Tenant. The waiver by Landlord or Tenant of any breach by the other of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of the same or any other term, covenant or
condition herein contained. 
 38. Waiver of Jury Trial and Counterclaims. The parties waive trial by jury in any action, proceeding
or counterclaim brought by the other party hereto related to matters arising out of or in any way connected with this Lease; the relationship between Landlord and Tenant; Tenant’s use or occupancy of the Premises, the Building or the Project;
or any claim of injury or damage related to this Lease or the Premises, the Building or the Project. 
 39. Intentionally deleted. 

40. Hazardous Materials. 

40.1 Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be brought upon, kept or used in or about the
Premises, the Building or the Project in violation of Applicable Laws by Tenant, its agents, employees, contractors or invitees. If Tenant breaches such obligation, or if the presence of Hazardous Materials as a result of such a breach results in
contamination of the Premises, the Building, the Project or any adjacent property, or if contamination of the Premises by Hazardous Materials otherwise occurs during the Term of this Lease or any extension or renewal hereof or holding over
hereunder, then Tenant shall indemnify, save, defend and hold Landlord, its agents and contractors harmless from and against any and all 

  
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claims, judgments, damages, penalties, fines, costs, liabilities and losses (including, without limitation, diminution in value of the Premises, the Building, the Project or any portion thereof;
damages for the loss or restriction on use of rentable or usable space or of any amenity of the Premises or Project; damages arising from any adverse impact on marketing of space in the Premises, the Building or the Project; and sums paid in
settlement of claims, attorneys’ fees, consultants’ fees and experts’ fees) that arise during or after the Term as a result of such breach or contamination. This indemnification of Landlord by Tenant includes, without limitation,
costs incurred in connection with any investigation of site conditions or any cleanup, remedial, removal or restoration work required by any Governmental Authority because of Hazardous Materials present in the air, soil or groundwater above, on or
under the Premises. Without limiting the foregoing, if the presence of any Hazardous Materials in, on, under or about the Premises, the Building, the Project or any adjacent property caused or permitted by Tenant results in any contamination of the
Premises, the Building, the Project or any adjacent property, then Tenant shall promptly take all actions at its sole cost and expense as are necessary to return the Premises, the Building, the Project and any adjacent property to their respective
condition existing prior to the time of such contamination; provided that Landlord’s written approval of such action shall first be obtained, which approval Landlord shall not unreasonably withhold; and provided, further,
that it shall be reasonable for Landlord to withhold its consent if such actions could have a material adverse long-term or short-term effect on the Premises, the Building or the Project. 

40.2 Landlord acknowledges that it is not the intent of this Article 40 to prohibit Tenant from operating its business as
described in Section 2.9 above. Tenant may operate its business according to the custom of Tenant’s industry so long as the use or presence of Hazardous Materials is strictly and properly monitored according to Applicable Laws. As a
material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the Term Commencement Date a list identifying each type of Hazardous Material to be present on
the Premises and setting forth any and all governmental approvals or permits required in connection with the presence of such Hazardous Material on the Premises (the “Hazardous Materials List”). Tenant shall deliver to Landlord an
updated Hazardous Materials List promptly after any material changes to the types or amounts of Hazardous Materials used by Tenant in the Premises. Tenant shall deliver to Landlord true and correct copies of the following documents (hereinafter
referred to as the “Documents”) relating to the handling, storage, disposal and emission of Hazardous Materials prior to the Term Commencement Date or, if unavailable at that time, concurrent with the receipt from or submission to
any Governmental Authority: permits; approvals; reports and correspondence; storage and management plans; notices of violations of Applicable Laws; plans relating to the installation of any storage tanks to be installed in or under the Premises, the
Building or the Project (provided that installation of storage tanks shall only be permitted after Landlord has given Tenant its written consent to do so, which consent Landlord may withhold in its sole and absolute discretion); and all
closure plans or any other documents required by any and all Governmental Authorities for any storage tanks installed in, on or under the Premises, the Building or the Project for the closure of any such storage tanks. Tenant shall not be required,
however, to provide Landlord with any portion of the Documents containing information of a proprietary nature that, in and of themselves, do not contain a reference to any Hazardous Materials or activities related to Hazardous Materials. Upon
Landlord’s written request, 

  
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Tenant agrees that it shall enter into a reasonable written agreement with other tenants of the Building and the Project concerning the equitable allocation of fire control areas (as defined in
the Uniform Building Code as adopted by the city or municipality(ies) in which the Project is located (the “UBC”)) within the Building and the Project for the storage of Hazardous Materials. In the event that Tenant’s use of
Hazardous Materials is such that it utilizes fire control areas in the Building or the Project in excess of Tenant’s Pro Rata Share of the Building or the Project, as applicable, as set forth in Section 2.2, Tenant agrees that it
shall, at its sole cost and expense and upon Landlord’s written request, establish and maintain a separate area of the Premises classified by the UBC as an “H” occupancy area for the use and storage of Hazardous Materials or take such
other action as is necessary to ensure that its share of the fire control areas of the Building and the Project is not greater than Tenant’s Pro Rata Share of the Building or the Project, as applicable. 

40.3 Notwithstanding the provisions of Section 40.1 above, if Tenant (a) has been required by any prior landlord, Lender or
Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property if the contamination resulted from such party’s action or omission or use of the property in question, or (b) is subject to an
enforcement order issued by any Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, then Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute discretion (with respect
to any such matter involving Tenant) at any time within one hundred eighty (180) days after the date Landlord actually becomes aware of such requirement or order, as applicable; provided, however, that unless such property is the
Property, this Section 40.3 shall not apply to any assignee of Tenant that (x) purchases all or substantially all of the assets of Tenant, and (y) has a net worth of at least $100,000,000. 

40.4 Notwithstanding the provisions of Section 40.1 above, if any proposed transferee, assignee or sublessee of Tenant
(a) has been required by any prior landlord, Lender or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property if the contamination resulted from such party’s action or omission or use
of the property in question, or (b) is subject to an enforcement order issued by any Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, then it shall not be unreasonable for Landlord to withhold its
consent to any proposed transfer, assignment or subletting (with respect to any such matter involving such proposed transferee, assignee or sublessee); provided, however, that this Section 40.4 shall not apply in the case
of any assignment of this Lease by Tenant to any assignee that (x) purchases all or substantially all of the assets of Tenant, and (y) has a net worth of at least $100,000,000. 

40.5 At any time, and from time to time, prior to the expiration of the Term, if Landlord has a reasonable basis to believe that Tenant has
violated this Article 40, Landlord shall have the right to conduct appropriate tests of the Premises, the Building and the Project to demonstrate that Hazardous Materials are present or that contamination has occurred due to Tenant or
Tenant’s agents, employees or invitees. Tenant shall pay all reasonable costs of such tests of the Premises if a violation by Tenant is found to have occurred. 

  
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 40.6 If underground or other storage tanks storing Hazardous Materials are located on the
Premises or are hereafter placed on the Premises by any party, Tenant shall monitor the storage tanks, maintain appropriate records, implement reporting procedures, properly close any underground storage tanks, and take or cause to be taken all
other steps necessary or required under the Applicable Laws. 
 40.7 Tenant’s obligations under this Article 40 shall
survive the expiration or earlier termination of the Lease. During any period of time needed by Tenant or Landlord after the termination of this Lease to complete the removal from the Premises of any such Hazardous Materials, Tenant shall continue
to pay Rent in accordance with this Lease, which Rent shall be prorated daily. 
 40.8 As used herein, the term “Hazardous
Material” means any hazardous or toxic substance, material or waste that is or becomes regulated by any Governmental Authority. 

41. Miscellaneous. 
 41.1
Where applicable in this Lease, the singular includes the plural and the masculine or neuter includes the masculine, feminine and neuter. The section headings of this Lease are not a part of this Lease and shall have no effect upon the construction
or interpretation of any part hereof. 
 41.2 Submission of this instrument for examination or signature by Tenant does not constitute a
reservation of or option for a lease, and shall not be effective as a lease or otherwise until execution by and delivery to both Landlord and Tenant. 

41.3 Time is of the essence with respect to the performance of every provision of this Lease in which time of performance is a factor. 

41.4 Each provision of this Lease performable by Tenant or Landlord shall be deemed both a covenant and a condition. 

41.5 Whenever consent or approval of either party is required, that party shall not unreasonably withhold, condition or delay such consent or
approval, except as may be expressly set forth to the contrary. 
 41.6 The terms of this Lease are intended by the parties as a final
expression of their agreement with respect to the terms as are included herein, and may not be contradicted by evidence of any prior or contemporaneous agreement. 

41.7 Any provision of this Lease that shall prove to be invalid, void or illegal shall in no way affect, impair or invalidate any other
provision hereof, and all other provisions of this Lease shall remain in full force and effect and shall be interpreted as if the invalid, void or illegal provision did not exist. 

  
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 41.8 Landlord may, but shall not be obligated to, record this Lease or a short form memorandum
hereof if approved by Tenant, which consent shall not be unreasonably withheld, conditioned or delayed. Neither party shall record this Lease. Landlord shall be responsible for the cost of recording any memorandum of this Lease, including any
transfer or other taxes incurred in connection with said recordation. 
 41.9 The language in all parts of this Lease shall be in all cases
construed as a whole according to its fair meaning and not strictly for or against either Landlord or Tenant. 
 41.10 Each of the
covenants, conditions and agreements herein contained shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs; legatees; devisees; executors; administrators; and permitted successors,
assigns, sublessees. Nothing in this Section 41.10 shall in any way alter the provisions of this Lease restricting assignment or subletting. 

41.11 Any notice, consent, demand, bill, statement or other communication required or permitted to be given hereunder shall be in writing and
shall be given by personal delivery, overnight delivery with a reputable nationwide overnight delivery service, or certified mail (return receipt requested), and if given by personal delivery, shall be deemed delivered upon receipt; if given by
overnight delivery, shall be deemed delivered one (1) day after deposit with a reputable nationwide overnight delivery service; and, if given by certified mail (return receipt requested), shall be deemed delivered three (3) business days
after the time the notifying party deposits the notice with the United States Postal Service. Any notices given pursuant to this Lease shall be addressed to Tenant at the Premises, or to Landlord or Tenant at the addresses shown in
Sections 2.11 and 2.12, respectively. Either party may, by notice to the other given pursuant to this Section, specify additional or different addresses for notice purposes. 

41.12 This Lease shall be governed by, construed and enforced in accordance with the laws of the State in which the Premises are located,
without regard to such State’s conflict of law principles. 
 41.13 Each of Landlord and Tenant warrant to the other that the
respective individual or individuals signing this Lease on its behalf has the power, authority and legal capacity to sign this Lease on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers or
other organizations and entities on whose behalf said individual or individuals have signed. 
 41.14 Tenant agrees that it shall promptly
furnish to Landlord, from time to time, upon Landlord’s written request, the most recent audited year-end financial statements reflecting Tenant’s current financial condition or, to the extent
audited financial statements are not available, year-end financial statements certified by Tenant’s chief financial officer as prepared in conformance with GAAP as it is related to accrued liabilities and
fairly representing Tenant’s current financial condition. Tenant represents and warrants that all financial statements, records and information furnished by Tenant to Landlord in connection with this Lease are true, correct and complete in all
material respects. 

  
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 41.15 This Lease may be executed in one or more counterparts, each of which, when taken together,
shall constitute one and the same document. 
 41.16 Landlord warrants that there are no recorded covenants, conditions or restrictions on
the Project or Property (the “CC&Rs”) that materially interfere with Tenant’s ability to use the Premises for the Permitted Use. 

42. Option to Extend Term. Tenant shall have the option (“Option”) to extend the Term of this Lease by five
(5) years (the “Extension Term”) as to the entire Premises (and no less than the entire Premises) upon the following terms and conditions. Any extension of the Term pursuant to the Option shall be on all the same terms and
conditions as this Lease, except as follows: 
 42.1 Basic Annual Rent shall be adjusted on the first (1st) day of the Extension Term
and each anniversary date thereof in accordance with Article 7. The Basic Annual Rent during the Extension Term shall equal the greater of: (a) ninety-five percent (95%) of the Fair Market Value for the Extension Term; and
(b) 103% of the then-current Basic Annual Rent at the end of the then-current Term, and shall be adjusted in accordance with Article 7 hereof. “Fair Market Value” means the then-prevailing average annual rate that
comparable landlords have accepted in current transactions from new, non-equity (i.e., not being offered equity in the Building), nonrenewal, nonexpansion and nonaffiliated tenants of similar financial
strength for comparable space in comparable laboratory buildings comparably located, with comparable size, quality and floor height in a first class office building, or as appropriate, a laboratory building, taking into consideration all relevant
factors, including, without limitation, the proposed lease term, the tenant inducements, free rent, brokerage commissions, allowances or concessions, if any, and excluding specialized tenant improvements or tenant paid improvements for a comparable
term, with the determination of Fair Market Value to take into account all relevant factors, including tenant inducements, allowances or concessions, if any, the extent of the services provided or to be provided to the Premises, and contraction and
expansion options. In the event the tenant inducements, allowances or concessions granted differ from the terms contained in this Lease, an adjustment to the Fair Market Value shall be made on a basis consistent with the adjustments commonly made in
the market for comparable differences and concession packages. If Landlord and Tenant cannot agree on the Fair Market Value for purposes of the Extension Term then they shall engage a mutually agreeable independent third party appraiser with at
least ten (10) years’ experience in appraising the rental value of leased commercial premises (for research and development and laboratory uses) in the Seattle, Washington area (the “Appraiser”). If the parties cannot
agree on the Appraiser, each shall within ten (10) days after such impasse appoint an Appraiser and, within ten (10) days after the appointment of both such Appraisers, those two Appraisers shall select a third. If either party fails to
timely appoint an Appraiser, then the Appraiser the other party appoints shall be the sole Appraiser. Within ten (10) days after appointment of all Appraiser(s), Landlord and Tenant shall each simultaneously give the Appraisers (with a copy to
the other party) its determination of Fair Market Value, with such supporting data or information as each submitting party determines appropriate. Within ten (10) days after such submissions, the Appraisers shall by majority vote select either
Landlord’s or Tenant’s Fair Market Value. The Appraisers may not select or designate any other Fair Market Value. The determination of the Appraiser(s) shall bind the parties. 

  
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 42.2 The Option is not assignable separate and apart from this Lease except that it shall be
exercisable by a Tenant’s Affiliate to which this Lease has been assigned in accordance herewith. 
 42.3 The Option is conditional
upon Tenant giving Landlord written notice of its election to exercise the Option at least nine (9) months prior to the end of the expiration of the initial Term of this Lease. Time shall be of the essence as to Tenant’s exercise of the
Option. Tenant assumes full responsibility for maintaining a record of the deadlines to exercise the Option. Tenant acknowledges that it would be inequitable to require Landlord to accept any exercise of the Option after the date provided for in
this paragraph. 
 42.4 Notwithstanding anything contained in this Article 42, Tenant shall not have the right to exercise the
Option: 
 (a) During the time commencing from the date Landlord delivers to Tenant a written notice that Tenant is actually in default
under any provisions of this Lease and continuing until Tenant has cured the specified default to Landlord’s reasonable satisfaction; or 

(b) At any time after any Default as described in Article 25 of the Lease and continuing until Tenant cures any such Default, if
such Default is susceptible to being cured; or 
 (c) In the event that Tenant has defaulted (beyond applicable notice and cure periods) in
the performance of its obligations under this Lease two (2) or more times and a service or late charge has become payable under Section 25.1 for each of such defaults during the twelve (12)-month period immediately prior to the date
that Tenant intends to exercise the Option, whether or not Tenant has cured such defaults. 
 42.5 The period of time within which Tenant
may exercise the Option shall not be extended or enlarged by reason of Tenant’s inability to exercise such Option because of the provisions of Section 42.4. 

42.6 All of Tenant’s rights under the provisions of the Option shall terminate and be of no further force or effect even after
Tenant’s due and timely exercise of the Option if, after such exercise, but prior to the commencement date of the new term, (a) Tenant fails to pay to Landlord a monetary obligation of Tenant for a period of twenty (20) days after
written notice from Landlord to Tenant, (b) Tenant fails to commence to cure a default (other than a monetary default) within thirty (30) days after the date Landlord gives notice to Tenant of such default or (c) Tenant has defaulted
(beyond applicable notice and cure periods) under this Lease two (2) or more times and a service or late charge under Section 25.1 has become payable for any such default, whether or not Tenant has cured such defaults. 

43. Right of First Refusal. Tenant shall have a continuing right of first refusal (“ROFR”) as to any premises on the
first and third floors of the Building for which Landlord is seeking a tenant (“Available Premises”) from time to time during the Term and extensions thereof. To the extent that Landlord renews or extends a then-existing lease with
any then-existing tenant of any space, or 

  
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enters into a new lease with such then-existing tenant for the same premises, the affected space shall not be deemed to be Available Premises. In addition, space that has not been rented since
the completion of the Building shall be Available Premises. In the event Landlord makes to a third party, or receives from a third party, a offer to lease Available Premises that Landlord is willing to accept, Landlord shall provide written notice
thereof to Tenant (the “Notice of Offer”), specifying the terms and conditions of a proposed lease to Tenant of the Available Premises. 

43.1 Within ten (10) days following its receipt of a Notice of Offer, Tenant shall advise Landlord in writing whether Tenant elects to
lease the Available Premises on the terms and conditions set forth in such Notice of Offer. If Tenant fails to notify Landlord of Tenant’s election within said ten (10) day period, then Tenant shall be deemed to have elected not to lease
the Available Premises. 
 43.2 If Tenant timely notifies Landlord that Tenant elects to lease the Available Premises on the terms and
conditions set forth in the Notice of Offer, then Landlord shall lease the Available Premises to Tenant upon the terms and conditions set forth in the Notice of Offer. 

43.3 If Tenant notifies Landlord that Tenant elects not to lease the Available Premises on the terms and conditions set forth in the Notice of
Offer, or if Tenant fails to notify Landlord of Tenant’s election within the ten (10)-day period described above, then Landlord shall have the right to consummate the lease of the Available Premises on
the same terms as are in the Notice of Offer, or on terms that, in Landlord’s reasonable, good faith judgment, are more favorable to Landlord or on other terms than are set forth in the Notice of Offer (provided that each of (a) the size
of any prospective subject space to be let, (b) the aggregate economic value based on the discounted present value (to be calculated with an eight percent (8%) annual interest factor) of the net rent and other amounts to be paid by the
tenant and the Landlord over the term of the lease of such space and the amount of the tenant improvement allowance, and (c) the length of the term of such prospective lease does not vary by more than seven and
one-half percent (7.5%) from those set forth in the Notice of Offer), within one hundred twenty (120) days following Tenant’s election (or deemed election) not to lease the Available Premises.
If Landlord does not lease the Available Premises within said one hundred twenty (120)-day period, then Tenant’s ROFR shall be fully reinstated with respect to the specific Available Premises, and
Landlord shall not thereafter lease the Available Premises without first complying with the procedures set forth in this Article 43. 

43.4 Notwithstanding anything in this Article 43 to the contrary, Tenant shall not exercise the ROFR during such period of time
that Tenant is in default beyond applicable notice and cure periods under any provision of this Lease. Any attempted exercise of the ROFR during a period of time in which Tenant is so in default shall be void and of no effect. In addition, Tenant
shall not be entitled to exercise the ROFR if Tenant has been in default (beyond applicable notice and cure periods) two (2) or more times during the twelve (12) month period prior to the date on which Tenant seeks to exercise the ROFR.

 43.5 Notwithstanding anything in this Lease to the contrary, Tenant shall not assign or transfer the ROFR, either separately or in
conjunction with an assignment or transfer of Tenant’s interest in the Lease, without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion; provided that this ROFR shall be
exercisable by Tenant’s Affiliate to which this Lease has been assigned in accordance with the terms hereof. 

  
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 43.6 If Tenant exercises the ROFR, Landlord does not guarantee that the Available Premises will
be available on the anticipated commencement date for the lease thereof if the then-existing occupants of the Additional Space shall hold over, or for any other reason beyond Landlord’s reasonable control. 

43.7 Notwithstanding anything in this Lease to the contrary, if the Available Premises consists of all or any portion of the first
(1St) floor, Tenant at its sole discretion may elect to exercise this ROFR with respect to all of such space on the first (1st) floor or with respect to only such portion thereof as Tenant may elect (so long as the portion of the first
(1st) floor that Tenant does not elect to lease is, in Landlord’s reasonable judgment, reasonably marketable). 
 44. Expansion
Option. 
 44.1 Subject to the conditions set forth in this Article 44, Tenant shall have the right, but not the obligation,
to expand the Premises (the “Expansion Option”) to include space in the basement or on the first floor of the Building (the “Potential Expansion Area”). The portion of the Potential Expansion Area added to the
Premises by exercise of the Expansion Option shall herein be referred to as the “Expansion Premises”. 
 44.2 Tenant may
exercise its Expansion Option under this Article 44 for any portion of the Potential Expansion Area that remains Available Space by providing Landlord with written notice (the “Expansion Option Exercise Notice”) that
Tenant has elected to exercise its Expansion Option for such space. A portion of the space in the Building shall be deemed “Available Space” if such portion is vacant and Tenant has not received a Notice of Offer in accordance with
Article 43 with respect to such portion. 
 44.3 Tenant acknowledges that Landlord shall have the right at any time in its sole
and absolute discretion to make improvements in addition to the Core and Shell Work to any portion of the Potential Expansion Area for which Tenant has not exercised its Expansion Option such that such portion of the Potential Expansion Area will be
ready for tenant occupancy (even if such portion of the Potential Expansion Area will not be suitable for Tenant’s use) (such improvements, “Spec Improvements”). If Landlord intends to make Spec Improvements to any portion of
the Potential Expansion Area, then Landlord shall endeavor to provide written notice to Tenant when Landlord applies for a building permit for the Spec Improvements, which notice shall state Landlord’s intent to complete such Spec Improvements
in such portion of the Potential Expansion Area (such portion of the Potential Expansion Area that is described in a Spec Space Notice (as defined below) as the portion that will be so improved, a “Spec Space Area”), and specify the
general nature of the Spec Improvements and the Spec Space Area (such notice, a “Spec Space Notice”). If Tenant desires to lease less than all of the Spec Space Area, then the Expansion Premises shall be determined in accordance
with Section 44.4, and such Spec Space Area shall be the Expansion Premises hereunder. If Tenant delivers an Expansion Option Exercise Notice with respect to any Spec Space Area before Landlord commences the Spec Improvements in such
Spec 

  
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Space Area, then, in its Expansion Option Exercise Notice, Tenant may clearly and explicitly notify Landlord that Tenant does not desire Landlord to complete the Spec Improvements (a
“Non-Spec Election”), and if Tenant timely provides such notice to Landlord, then Landlord shall not perform the Spec Improvements in such Spec Space Area, and instead the improvement of such Spec Space shall be governed by
Section 44.5. If Tenant does not make a Non-Spec Election in Tenant’s Expansion Option Exercise Notice, then Landlord shall perform the Spec Improvements in such Spec Space Area (a
“Leased Spec Area”), and shall not be required to perform any improvements in addition to the Core and Shell Work and the Spec Improvements, and Tenant shall not be entitled to any TI Allowance for the Leased Spec Area. 

44.4 If Tenant exercises its Expansion Option in accordance with Section 44.2 hereof with respect to: 

(a) any Spec Space Area, then Tenant shall, in its Expansion Option Exercise Notice, specify the number of square feet of Rentable Area of
Spec Space Area that Tenant requires. It Tenant requests less than the entire Rentable Area of Spec Space Area in its Expansion Option Exercise Notice, then Landlord shall subsequently designate as the Expansion Premises a portion of such Spec Space
Area, reasonably suitable for leasing and comprised of a number of square feet of Rentable Area that is approximately the same as the number of square feet of Rentable Area that is specified by Tenant in its Expansion Option Exercise Notice, but
only if there is Spec Space Area that meets each of the following requirements: 
 (i) The Rentable Area of such space is approximately the
same as the Rentable Area designated by Tenant in its Expansion Option Exercise Notice; and 
 (ii) Landlord can separately demise such
space in a reasonable manner so that (i) such space and (ii) the remaining space located on such floor of the Building (if any) are of a commercially reasonable and marketable configuration and are suitable for leasing, including having
access to the common areas on the applicable floor (in the case of (ii) above, without reducing the rent per square foot that such remaining space would be expected to attain on the open market). 

(b) any portion of the Potential Expansion Area for which Landlord has not delivered a Spec Space Notice and which is Available Space
(“Available Non-Spec Space”), then Tenant shall, in its Expansion Option Exercise Notice, specify the number of square feet of Rentable Area of Available
Non-Spec Space that Tenant requires. Landlord shall subsequently designate as the Expansion Premises a portion of the Potential Expansion Area that is Available Non-Spec
Space, reasonably suitable for leasing and comprised of a number of square feet of Rentable Area that is approximately the same as the number of square feet of Rentable Area that is specified by Tenant in its Expansion Option Exercise Notice, but
only if there is Potential Expansion Area that meets each of the following requirements: 
 (i) The Rentable Area of such space is
approximately the same as the Rentable Area designated by Tenant in its Expansion Option Exercise Notice; 

  
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 (ii) Landlord can separately demise such space in a reasonable manner so that (i) such
space and (ii) the remaining space located on such floor of the Building (if any) are of a commercially reasonable and marketable configuration and are suitable for leasing, including having access to the common areas on the applicable floor
(in the case of (ii) above, without reducing the rent per square foot that such remaining space would be expected to attain on the open market); 

(iii) Such space is Available Non-Spec Space; and 

(iv) Landlord has not delivered a Spec Space Notice with respect to such space. 

Tenant shall pay all costs and expenses of separately demising the Expansion Premises. 

44.5 In the event Tenant exercises its Expansion Option in accordance with the terms of this Article 44 with respect to Available Non-Spec Space or any Spec Space Area for which Tenant has made a Non-Spec Election, Tenant may, by providing written notice to Landlord at any time during the twelve
(12) month period (the “Expansion Tenant Improvement Election Period”) immediately following the later of the date of the Expansion Option Exercise Notice provided by Tenant to Landlord for such space or Substantial Completion
of the Core and Shell Work, request in writing (the “Expansion Premises TI Notice”) that Landlord construct tenant improvements to such Expansion Premises in accordance with the terms of Article 4 of this Lease and the
Work Letter (with such modifications thereto as may reasonably be necessary to reflect that the Tenant Improvements for such Expansion Premises will be governed by this Article 44 to the extent inconsistent with Article 44);
provided, however, Tenant shall deliver its Draft Plans for the Expansion Premises Tenant Improvements to Landlord within sixty (60) days after Tenant provides its Expansion Premises TI Notice for such Expansion Premises to
Landlord; provided, further, that the TI Allowance for such Expansion Premises shall be treated separately for such Expansion Premises and determined based on the rentable square footage of the Expansion Premises; provided,
further, that Tenant shall have until the earlier of (a) the occurrence of a Default after notice and the lapse of any applicable cure periods (which shall be the notice and cure periods specified in Article 25 and not
additional notice or cure periods) or (b) the expiration of the Expansion Tenant Improvement Election Period, to expend the unused portion of any TI Allowance with respect to such Expansion Premises, after which date Landlord’s obligation
to fund the TI Allowance for such Expansion Premises shall expire, and any Tenant Improvements made by Landlord to the applicable Expansion Premises after such date shall be made at Tenant’s sole cost and expense. Tenant and Landlord shall
amend the Work Letter to incorporate any additional tenant improvements requested by Tenant in accordance with this Section 44.5 within ten (10) days following Tenant’s provision of such notice to Landlord. 

44.6 Within ten (10) days after exercising the Expansion Option, Tenant and Landlord shall enter into a written amendment to this Lease
(the “Amendment”), which Amendment shall provide, unless otherwise agreed in writing: 
 (a) that the term commencement
date for the Expansion Premises (the “Expansion Space Term Commencement Date”) shall be the later of (i) the date of Substantial Completion of the Core and Shell Work and Tenant Improvements (or Spec Improvements in lieu of
Tenant Improvements for any Leased Spec Area) for the Expansion Premises or (ii) the Term Commencement Date for the initial Premises; 

  
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 (b) that the Premises under this Lease shall be increased to include the Expansion Premises as
of the Expansion Space Term Commencement Date; 
 (c) that the Rentable Area of the Premises shall be increased to reflect the inclusion of
the Rentable Area of the Expansion Premises as of the Expansion Space Term Commencement Date; 
 (d) the new Basic Annual Rent, with the
Expansion Premises increasing the Basic Annual Rent as set forth in Section 44.8 hereof, provided, however, that if a Fair Market Rental Value determination is required in connection with such increase and the new Basic
Annual Rent is therefore not known at the time of execution of the Amendment, the Amendment shall indicate that the new Basic Annual Rent shall be determined in accordance with Section 44.8 of this Lease; 

(e) unless such Expansion Premises are Leased Spec Area, that Tenant shall commence paying Basic Annual Rent, and Tenant’s Share of
Operating Expenses, for any Expansion Premises commencing upon the later of (i) ten (10) days following the date of the Expansion Option Exercise Notice provided by Tenant to Landlord with respect to the Expansion Premises, or
(ii) eight (8) months following the the later of (A) the date of the Expansion Option Exercise Notice provided by Tenant to Landlord with respect to the Expansion Premises, or (B)the Substantial Completion of the Core and Shell Work
for such Expansion Premises, or (iii) the Rent Commencement Date; 
 (f) if such Expansion Premises are Leased Spec Area, that Tenant
shall commence paying Basic Annual Rent, and Tenant’s Share of Operating Expenses, for any Expansion Premises commencing upon the later of (i) ten (10) days following the date of the Expansion Option Exercise Notice provided by Tenant
to Landlord with respect to the Expansion Premises, or (ii) Substantial Completion of the Spec Improvements for the Leased Spec Area, or (iii) the Rent Commencement Date; 

(g) Tenant’s new Pro Rata Share of Operating Expenses based upon the addition of the Rentable Area of the Expansion Premises to the
Premises; 
 (h) the proportionate increase to the Security Deposit (which increase shall be payable to Landlord upon execution of the
Amendment); and 
 (i) the amount of the Initial TI Allowance and Additional TI Allowance (which amount shall exclude any TI Allowance for
Leased Spec Space). 

  
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 44.7 Landlord shall endeavor to tender possession of the Expansion Premises (with the Tenant
Improvements thereto (or Spec Improvements in lieu of Tenant Improvements for any Leased Spec Area) Substantially Complete) to Tenant on or before the estimated delivery date for the Expansion Premises (the “Expansion Estimated Delivery
Date”). If the Tenant Improvements (or Spec Improvements in lieu of Tenant Improvements for any Leased Spec Area) are not Substantially Complete on or before the Expansion Estimated Delivery Date for any reason whatsoever, then this Lease
shall not be void or voidable, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and the Expansion Space Term Commencement Date shall not occur until Substantial Completion of the Tenant Improvements for the
Expansion Premises occurs. Substantial Completion of Tenant Improvements for the Expansion Premises shall be determined separately from Substantial Completion for the remainder of the Premises. 

44.8 The initial Basic Annual Rent for the Expansion Premises shall be calculated as follows: 

(a) Unless the Expansion Premises is Leased Spec Area: 

(i) if the Expansion Option is exercised from and after the Execution Date until the Term Commencement Date, then the initial Basic Annual
Rent for such Expansion Premises shall be the rental rate per square foot of Rentable Area of the Expansion Premises set forth in Section 2.3 hereof; 

(ii) if the Expansion Option is exercised from and after the Teen Commencement Date until the first anniversary of the Term Commencement
Date, then the initial Basic Annual Rent for such Expansion Premises shall be the Fair Market Rental Value of the Expansion Premises (not to exceed 110% of the initial Basic Annual Rent per square foot of Rentable Area set forth in
Section 2.3 hereof); 
 (iii) if the Expansion Option is exercised after the first anniversary of the Term Commencement Date,
then the initial Basic Annual Rent for such Expansion Premises shall be the Fair Market Rental Value of the Expansion Premises; and 
 (b)
If the Expansion Premises is Leased Spec Space, then the initial Basic Annual Rent for such Expansion Premises shall be the Fair Market Rental Value for such space and improvements thereto with respect to such space, in which case Tenant shall not
be entitled to any TI Allowance in connection with such Expansion Premises. 
 Basic Annual Rent for the Expansion Premises shall escalate in accordance
with Article 7 of this Lease. 
 For purposes of this Article 44, the term “Fair Market Rental Value” of
the Expansion Premises is the greater of (a) the rental rate per square foot of Rentable Area of the Expansion Premises set forth in Section 2.3 hereof, or (b) the rental rate, determined in accordance with this
Article 44, at which tenants are leasing Comparable Space on the Expansion Space Term Commencement Date. For this purpose, “Comparable Space” shall mean office and laboratory

  
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space that is (v) not subleased, (w) not subject to another tenant’s expansion rights, (x) comparable in size, location and quality to the Expansion Premises, (y) leased
for a term comparable to Tenant’s lease of the Expansion Premises and (z) located in the Building and in other comparable office and laboratory projects located in the Seattle, Washington area. In determining the rental rate of Comparable
Space, the parties shall exclude brokerage commissions and shall include all escalations and take into consideration the following concessions: (i) rental abatement concessions, if any, being granted to tenants in connection with the Comparable
Space and (ii) tenant improvements or allowances provided or to be provided for the Comparable Space, taking into account the TI Allowance for, or value of the Spec Improvements in, the Expansion Premises, as the case may be. 

For any portion of the Expansion Premises for which Tenant has exercised its Expansion Option Exercise Notice and for which Basic Annual Rent
will be determined based on the Fair Market Rental Value of the Expansion Premises, Landlord shall provide written notice to Tenant of Landlord’s determination of the Fair Market Rental Value (“LL FMV Notice”) within fifteen
(15) business days following Landlord’s receipt of such Expansion Option Exercise Notice from Tenant. If Tenant disagrees with Landlord’s determination of the Fair Market Rental Value of the portion of the Expansion Premises as set
forth in the LL FMV Notice, then Tenant shall provide written notice to Landlord within ten (10) days following Tenant’s receipt of the LL FMV Notice notifying Landlord thereof (“Tenant FMV Objection Notice”). 

If Tenant does not deliver its Tenant FMV Objection Notice to Landlord by the end of such ten (10) day period, then the Fair Market
Rental Value of the Expansion Premises shall conclusively be determined to be the Fair Market Rental Value set forth in the LL FMV Notice. 

If Tenant does deliver its Tenant FMV Objection Notice to Landlord by the end of such ten (10) day period, then Landlord and Tenant shall
diligently attempt in good faith to agree upon the Fair Market Rental Value for such portion of the Expansion Premises on or before the fifth (5th) business day after Landlord’s receipt of the Tenant FMV Objection Notice. If Landlord and
Tenant fail to reach agreement on or before such date, the matter shall be arbitrated by a single arbitrator in accordance with Commercial Arbitration Rules of the American Arbitration Association. The arbitrator’s decision shall be limited to
determining the Fair Market Rental Value of such portion of the Expansion Premises. The arbitrator shall have no authority to make any other rulings or fashion any other remedy. The decision of the arbitrator shall be final. The party losing the
arbitration shall reimburse the prevailing party for all of the prevailing party’s reasonable fees, costs and expenses of the arbitration, including reasonable attorneys’ fees and the arbitrator’s fees. 

44.9 Landlord shall use good faith efforts to cause Contractor to repair any defects in the Expansion Premises identified by Tenant to
Landlord within nine (9) months of Tenant’s occupation of the Expansion Premises. Notwithstanding the foregoing, Landlord warrants that as of the Expansion Space Tenn Commencement Date (a) the Expansion Premises shall substantially
comply with all Applicable Laws; (b) any portion of the Expansion Premises consisting of Spec Space Area shall be constructed substantially in conformance with Landlord’s plans for such Spec Space Area, (c) any portion of the
Expansion Premises consisting of Available Non-Spec Space or for which Tenant makes a Non-Spec Election shall be constructed substantially in accordance with

  
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the Approved TI Plans and the Approved Core and Shell Plans for such space; and (d) the Expansion Premises shall be watertight. To the extent any of the warranties set forth in the preceding
sentence are violated, Landlord shall promptly correct the same at its sole cost. 
 44.10 Notwithstanding anything in this
Article 44 to the contrary, Tenant shall not exercise the Expansion Option during such period of time that Tenant is in default under any provision of this Lease after notice and the lapse of any applicable cure periods. Any attempted
exercise of the Expansion Option during a period of time in which Tenant is so in default shall be void and of no effect. In addition, Tenant shall not be entitled to exercise the Expansion Option if Landlord has given Tenant two (2) or more
notices of default under this Lease, whether or not the defaults are cured prior to the date on which Tenant seeks to exercise the Expansion Option. 

45. Tenant Option to Terminate. Tenant shall have the option to terminate this Lease (the “Termination Option”) with
no further rights or obligations hereunder in the event that Tenant (a) enters into a new lease for space in another building which is directly or indirectly owned or controlled by BioMed Realty Trust, Inc. (each, a “BioMed
Entity”) and (b) notifies Landlord and such BioMed Entity at least five (5) business days before Tenant executes such new Lease that Tenant is exercising such Termination Option and that Tenant intends to terminate this Lease.
Tenant shall exercise the Termination Option, if at all, within three (3) business days after Tenant enters into such a new lease. If Tenant enters into such a new lease and exercises the Termination Option in such a manner, then this Lease
shall be deemed to expire fifteen (15) days after Tenant commences to pay rent under such other lease, subject to all of the terms and conditions of this Lease with respect to the obligations of Landlord and Tenant upon expiration of this
Lease. Nothing in this Lease is intended to provide Tenant with any rights in any other such building, including any right to lease space in such a building, and neither Landlord nor any affiliate of Landlord (including any BioMed Entity) shall have
any obligation to negotiate with or otherwise entertain offers from Tenant with respect to any such space. The Termination Option shall not entitle Tenant to terminate the Lease with respect to less than all of the Premises. 

46. Authority. Tenant hereby covenants and warrants that (a) Tenant is duly incorporated or otherwise established or formed and
validly existing under the laws of its state of incorporation, establishment or formation, (b) Tenant has and is duly qualified to do business in the state in which the Property is located, (c) Tenant has full corporate, partnership,
trust, association or other appropriate power and authority to enter into this Lease and to perform all Tenant’s obligations hereunder and (d) each person (and all of the persons if more than one signs) signing this Lease on behalf of
Tenant is duly and validly authorized to do so. 
 47. Confidentiality. Tenant shall not disclose any terms or conditions of this
Lease (including Rent) or give a copy of this Lease to any third party, and Landlord shall not release to any third party any nonpublic financial information or nonpublic information about Tenant’s ownership structure, business or research
(“Tenant Information”), except (a) if required by Applicable Laws or in any judicial proceeding, provided that the releasing party has given the other party reasonable notice of such requirement, if feasible, (b) to
a party’s attorneys, accountants, brokers and other bona fide consultants or advisers, provided such third parties agree to be bound by this paragraph or (c) to bona fide prospective assignees or subtenants of this Lease. Landlord
shall not use any nonpublic Tenant Information in connection with any trading by Landlord of the capital stock of Tenant. 

  
 -61- 

 48. Odors and Exhaust. Tenant acknowledges that Landlord would not enter into this Lease
with Tenant unless Tenant assured Landlord that under no circumstances will any other occupants of the Building or Project (including persons legally present in any outdoor areas of the Project) be subjected to reasonably offensive odors or fumes
(whether or not noxious), and that the Building and Project will not be damaged by any exhaust, in each case from Tenant’s operations. Landlord acknowledges that Tenant is a laboratory user, and that as such there may be odors and exhaust
generated that differ from those generated by an office user. Landlord and Tenant therefore agree as follows: 
 48.1 Tenant shall not cause
or permit (or conduct any activities that would cause) any release of any reasonably offensive odors or fumes of any kind from the Premises. 

48.2 The Building has a ventilation system that in Landlord’s judgment (and taking Tenant’s Permitted Use of the Premises into
account) is adequate, suitable, and appropriate to vent the Premises in a manner that does not release odors affecting any indoor or outdoor part of the Project, and Tenant agrees to vent the Premises through such system. The placement and
configuration of any further ventilation exhaust pipes, louvers and other equipment shall be subject to Landlord’s reasonable approval. Subject to the foregoing, Tenant acknowledges Landlord’s legitimate desire to maintain the Project
(indoor and outdoor areas) in a reasonably odor-free manner (taking into account that the Building is a laboratory building), and Landlord may reasonably require Tenant to abate and remove all odors in a manner that goes beyond the requirements of
Applicable Laws. 
 48.3 If Tenant’s activities in the Premises generate odors that are not vented by the Building’s ventilation
system (as described in the prior paragraph), and if such odors are reasonably offensive to other tenants, then Tenant shall, at Tenant’s sole cost and expense, provide odor eliminators and other devices (such as filters, air cleaners,
scrubbers and whatever other equipment may in Landlord’s reasonable judgment be necessary or appropriate from time to time) to reasonably abate any odors, fumes or other substances in Tenant’s exhaust stream that, in Landlord’s
reasonable judgment, emanate from Tenant’s Premises. Any work Tenant performs under this paragraph shall constitute Alterations. 

48.4 Tenant’s responsibility to abate odors, fumes and exhaust shall continue throughout the Term. Landlord’s approval of the Tenant
Improvements shall not preclude Landlord from requiring additional measures to eliminate odors, fumes and other adverse impacts of Tenant’s exhaust stream (as Landlord may designate in Landlord’s reasonable discretion). Tenant shall
install additional equipment as Landlord reasonably requires from time to time under the preceding sentence. Such installations shall constitute Alterations. 

48.5 If Tenant fails to install satisfactory odor control equipment within twenty (20) business days after Landlord’s demand (as set
forth above) made at any time, then Landlord may, without limiting Landlord’s other rights and remedies, require Tenant to cease and suspend any 

  
 -62- 

 
operations in the Premises that, in Landlord’s determination, cause odors, fumes or exhaust. For example, if Landlord reasonably determines that Tenant’s production of a certain type of
product causes odors, fumes or exhaust, and Tenant does not install satisfactory odor control equipment within twenty (20) business days after Landlord’s request, then Landlord may require Tenant to stop producing such type of product in
the Premises unless and until Tenant has installed odor control equipment satisfactory to Landlord. 
 49. HVAC. For the Premises,
Landlord shall (a) maintain and operate the heating, ventilating and air conditioning systems used for typical laboratory use (“HVAC”), and (b) subject to clause (a) above, furnish HVAC as reasonably required (except
as this Lease otherwise provides or as to any special requirements that arise from Tenant’s particular use of the Premises for other than typical laboratory use) for reasonably comfortable occupancy of the Premises twenty-four (24) hours a
day, 365 or 366 days a year. If Tenant will require HVAC outside normal business hours of business days (as reasonably designated by Landlord) in the Premises (“Overtime HVAC”), then Landlord shall be obligated to provide Overtime
HVAC only if Tenant requests it by 4 p.m. on the immediately preceding business day. Notwithstanding anything to the contrary in this paragraph, Landlord shall have no liability, and Tenant shall have no right or remedy, on account of any
interruption or impairment in HVAC services, except as otherwise set forth in this Lease, and provided that Landlord diligently endeavors to cure any such interruption or impairment. 

50. Excavation. If any excavation shall be made upon land adjacent to or under the Building, or shall be authorized to be made, Tenant
shall afford to the person causing or authorized to cause such excavation, reasonable license to enter the Premises for the purpose of performing such work as said person shall deem necessary or desirable to preserve and protect the Building from
injury or damage and to support the same by proper foundations, without any claim for damages or liability against Landlord and without reducing or otherwise affecting Tenant’s obligations under this Lease so long as Tenant’s use and
enjoyment of the Premises is not materially interfered with. 
 51. Names. Landlord reserves the right to change the name of the
Project or the Building in its sole discretion. 
 52. Good Faith. As used herein, the term “good faith” shall be
subjective in nature (based on the perspective of the person or entity that is acting). A decision shall be deemed to be made in “good faith” if the person who makes the decision believes (without regard to whether such belief is
reasonable) that it is appropriate and is made without dishonesty or fraud; and “good faith efforts” shall mean such efforts as the person or entity that takes such actions believes (without regard to whether such belief is reasonable) are
appropriate under the circumstances or likely to achieve the desired result. 
 53. Substantially Conform or Comply. References in
this Lease to “substantially conform” or “substantially comply” shall mean that the item in question complies but for issues that do not result in material additional incremental costs to Tenant or materially interfere with
Tenant’s ability to use or enjoy the Premises in accordance with the Lease. 
 [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
 -63- 

 IN WITNESS WHEREOF, the parties hereto have executed this Lease as of the date first above
written. 
  

			
	LANDLORD:
	
	 BMR-530 FAIRVIEW AVENUE LLC,

a Delaware limited liability company

		
	By:		 /s/ Kent Griffin

	Name:		 Kent Griffin

	Title:		 CFO

	
	TENANT:
	
	 NANOSTRING TECHNOLOGIES, INC.,
 a
Delaware corporation

		
	By:		 /s/ Wayne Burns

	Name:		 Wayne Burns

	Title:		 CFO

  
 [SIGNATURE PAGE TO
LEASE] 

 NOTARIZATION (required in the State of Washington) 

STATE OF CALIFORNIA) 

                          
  : ss. 
 COUNTY OF San Diego) 

I certify that I know or have satisfactory evidence that Kent Griffin is the person who appeared before me, and s/he acknowledged that
s/he signed this instrument, on oath stated that s/he was authorized to execute the instrument and acknowledged it as the Chief Financial Officer of BMR-530 Fairview LLC, a corporation, to be the
free and voluntary act of such corporation for the uses and purposes mentioned in the instrument. 
 Dated this 25 day of
October, 2007. 
  

	
	 /s/ Christy D. Bartlett

	[Signature of Notary]
	
	 Christy D. Bartlett

	[Print Name of Notary]

 STATE OF WASHINGTON) 

                          
  : ss. 
 COUNTY OF King) 
 I
certify that I know or have satisfactory evidence that Wayne Burns is the person who appeared before me, and s/he acknowledged that s/he signed this instrument, on oath stated that s/he was authorized to execute the instrument and
acknowledged it as the Chief Financial Officer of NanoString Technologies, a corporation, to be the free and voluntary act of such corporation for the uses and purposes mentioned in the instrument. 

Dated this 19 day of October, 2007. 

 

	
	 /s/ Susan R. Van Den Ameele

	[Signature of Notary]
	
	 Susan R. Van Den Ameele

	[Print Name of Notary]
	
	Notary Public in and for the State of
	Washington, residing at Seattle.
	My commission expires: 09.21.11.

  
 [SIGNATURE PAGE TO
LEASE] 

 EXHIBIT A 

PREMISES 
 SECOND FLOOR

  
 

 

  
 

 

 EXHIBIT B 

ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE 

AND TERM EXPIRATION DATE 

THIS ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE AND TERM EXPIRATION DATE is entered into as of
[            ], 20[    ], with reference to that certain Lease (the “Lease”) dated as of October 19, 2007, by NANOSTRING TECHNOLOGIES, INC., a
Delaware corporation (“Tenant”), in favor of BMR-350 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”). All capitalized terms used herein without
definition shall have the meanings ascribed to them in the Lease. 
 Tenant hereby confirms the following: 

1. Tenant accepted possession of the Premises on [            ],
20[    ]. 
 2. To the best of Tenant’s knowledge after reasonable investigation, the Premises are in good order,
condition and repair. 
 3. To the best of Tenant’s knowledge after reasonable investigation, the Tenant Improvements required to be
constructed by Landlord under the Lease have been substantially completed. 
 4. To the best of Tenant’s knowledge after reasonable
investigation, all conditions of the Lease to be performed by Landlord as a condition to the full effectiveness of the Lease have been satisfied, and Landlord has fulfilled all of its duties in the nature of inducements offered to Tenant to lease
the Premises. Tenant acknowledges that the Term Commencement Date shall not be delayed as a result of any issues discovered by Tenant during such investigation. 

5. Notwithstanding the failure of any conditions to the occurrence of the Term Commencement Date, in accordance with the provisions of
Section 4.2 of the Lease, the Term Commencement Date is [            ], 20[    ], and, unless the Lease is terminated prior to the Term Expiration Date
pursuant to its terms, the Term Expiration Date shall be [            ], 20[    ]. 

6. Tenant commenced occupancy of the Premises for the Permitted Use on
[            ], 20[    ]. 
 7. The Lease is in full force
and effect, and the same represents the entire agreement between Landlord and Tenant concerning the Premises[, except [            ]]. 

8. To the best of Tenant’s knowledge after reasonable investigation, Tenant has no existing defenses against the enforcement of the Lease
by Landlord, and there exist no offsets or credits against Rent owed or to be owed by Tenant. 

  
 B-1 

 9. The obligation to pay Rent is presently in effect and all Rent obligations on the part of
Tenant under the Lease commenced to accrue on [            ], 20[    ]. 

10. The undersigned Tenant has not made any prior assignment, transfer, hypothecation or pledge of the Lease or of the rents thereunder or
sublease of the Premises or any portion thereof. 
 [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
 B-2 

 IN WITNESS WHEREOF, the parties hereto have executed this Acknowledgment of Term Commencement
Date and Term Expiration Date as of [            ], 20[    ]. 
  

			
	TENANT:
	
	 NANOSTRING TECHNOLOGIES, INC.
 a
Delaware corporation

		
	By:		  

	Name:		  

	Title:		  

  
 B-3 

 EXHIBIT C 

[INTENTIONALLY DELETED] 

  
 C-1 

 EXHIBIT D 

RULES AND REGULATIONS 
 NOTHING IN
THESE RULES AND REGULATIONS (“RULES AND REGULATIONS”) SHALL SUPPLANT ANY PROVISION OF THE LEASE. IN THE EVENT OF A CONFLICT OR INCONSISTENCY BETWEEN THESE RULES AND REGULATIONS AND THE LEASE, THE LEASE SHALL PREVAIL. 

1. Except as specifically provided in the Lease to which these Rules and Regulations are attached, no sign, placard, picture, advertisement,
name or notice shall be installed or displayed on any part of the outside of the Premises or the Building without Landlord’s prior written consent. Landlord shall have the right to remove, at Tenant’s sole cost and expense and without
notice, any sign installed or displayed in violation of this rule. 
 2. If Landlord objects in writing to any curtains, blinds, shades,
screens or hanging plants or other similar objects attached to or used in connection with any window or door of the Premises or placed on any windowsill, which window, door or windowsill is (a) visible from the exterior of the Premises and
(b) not included in plans approved by Landlord, then Tenant shall promptly remove said curtains, blinds, shades, screens or hanging plants or other similar objects at its sole cost and expense. 

3. Tenant shall not obstruct any sidewalks or entrances to the Building, or any halls, passages, exits, entrances or stairways within the
Premises, in any case that are required to be kept clear for health and safety reasons. 
 4. No deliveries shall be made that impede or
interfere with other tenants in or the operation of the Project. 
 5. Tenant shall not place a load upon any floor of the Premises that
exceeds the load per square foot that (a) such floor was designed to carry or (b) that is allowed by Applicable Laws. Fixtures and equipment that cause noises or vibrations that may be transmitted to the structure of the Building to such a
degree as to be objectionable to other tenants shall be placed and maintained by Tenant, at Tenant’s sole cost and expense, on vibration eliminators or other devices sufficient to eliminate such noises and vibrations to levels reasonably
acceptable to Landlord and other tenants of the Building. 
 6. Tenant shall not use any method of heating or air conditioning other than
that shown in the Tenant Improvement plans. 
 7. Tenant shall not install any radio, television or other antenna, cell or other
communications equipment, or any other devices on the roof or exterior walls of the Premises except to the extent shown on approved Tenant Improvements plans. Tenant shall not interfere with radio, television or other communications from or in the
Premises or elsewhere. 

  
 D-1 

 8. Canvassing, peddling, soliciting and distributing handbills or any other written material
within, on or around the Project (other than within the Premises) are prohibited and Tenant shall cooperate to prevent such activities. 

9. Tenant shall store all of its trash, garbage and Hazardous Materials within its Premises or in designated receptacles outside of the
Premises. Tenant shall not place in any such receptacle any material that cannot be disposed of in the ordinary and customary manner of trash, garbage and Hazardous Materials disposal. 

10. The Premises shall not be used for any improper, immoral or objectionable purpose. No cooking shall be done or permitted on the Premises;
provided, however, that Tenant may use (a) equipment approved in accordance with the requirements of insurance policies that Landlord or Tenant is required to purchase and maintain pursuant to the Lease for brewing coffee, tea,
hot chocolate and similar beverages, (b) microwave ovens for employees’ use and (c) equipment shown on Tenant Improvement plans approved by Landlord; provided, further, that any such equipment and microwave ovens are used in
accordance with Applicable Laws. 
 11. Tenant shall not, without Landlord’s prior written consent, use the name of the Project, if
any, in connection with or in promoting or advertising Tenant’s business except as Tenant’s address. 
 12. Tenant shall comply
with all safety, fire protection and evacuation procedures and regulations established by Landlord or any Governmental Authority. 
 13.
Tenant assumes any and all responsibility for protecting the Premises from theft, robbery and pilferage, which responsibility includes keeping doors locked and other means of entry to the Premises closed. 

14. Landlord may waive any one or more of these Rules and Regulations for the benefit of Tenant or any other tenant, but no such waiver by
Landlord shall be construed as a waiver of such Rules and Regulations in favor of Tenant or any other tenant, nor prevent Landlord from therafter enforcing any such Rules and Regulations against any or all of the tenants of the Project, including
Tenant. 
 15. These Rules and Regulations are in addition to, and shall not be construed to in any way modify or amend, in whole or in
part, the terms covenants, agreements and conditions of the Lease. 
 16. Landlord reserves the right to make such other and reasonable
rules and regulations as, in its judgment, may from time to time be needed for safety and security, the care and cleanliness of the Project, or the preservation of good order therein; provided, however, that Landlord shall provide
written notice to Tenant of such rules and regulations prior to them taking effect. Tenant agrees to abide by these Rules and Regulations and any additional reasonable rules and regulations issued or adopted by Landlord. 

  
 D-2 

 17. Tenant shall be responsible for the observance of these Rules and Regulations by
Tenant’s employees, agents, clients, customers, invitees and guests. 

  
 D-3 

 EXHIBIT E 

FORM OF ESTOPPEL CERTIFICATE 
  

			
	To:		BMR-530 FAIRVIEW AVENUE LLC
			17140 Bernardo Center Drive, Suite 222
			San Diego, CA 92128
			Attention: General Counsel/Real Estate
		
			BioMed Realty, L.P.
			c/o BioMed Realty Trust, Inc.
			17140 Bernardo Center Drive, Suite 222
			San Diego, CA 92128
		
	Re:		Fairview Research Center (the “Premises”) at 530 Fairview Avenue, Seattle, Washington (the “Property”)

 The undersigned tenant (“Tenant”) hereby certifies to you as follows: 

1. Tenant is a tenant at the Property under a lease (the “Lease”) for the Premises dated as of October 19, 2007. The
Lease has not been cancelled, modified, assigned, extended or amended [except as follows: [            ]], and there are no other agreements, written or oral, affecting or relating to
Tenant’s lease of the Premises or any other space at the Property. The lease term expires on [            ], 20[    ]. 

2. Tenant took possession of the Premises, currently consisting of [            ]
square feet, on [            ], 20[    ], and commenced to pay rent on [            ],
20[    ]. Tenant has full possession of the Premises, has not assigned the Lease or sublet any part of the Premises, and does not hold the Premises under an assignment or sublease[, except as follows:
[            ]]. 
 3. All base rent, rent escalations and additional rent under
the Lease have been paid through [            ], 20[    ]. There is no prepaid rent[, except
$[            ][, and the amount of security deposit is $[            ][in cash] [in the form of a letter of credit]]. Tenant
currently has no right to any future rent abatement under the Lease. 
 4. Base rent is currently payable in the amount of
$[            ] per month. 
 5. Tenant is currently paying estimated payments
of additional rent of $[            ] per month on account of real estate taxes, insurance, management fees and common area maintenance expenses. 

6. All work to be performed for Tenant under the Lease has been performed as required under the Lease and has been accepted by Tenant[, except
[            ]], and all allowances to be paid to Tenant, including allowances for tenant improvements, moving expenses or other items, have been paid. 

  
 E-1 

 7. To the best of Tenant’s knowledge after due investigation, the Lease is in full force and
effect, free from default and free from any event that could become a default under the Lease, and Tenant has no claims against the landlord or offsets or defenses against rent, and there are no disputes with the landlord. Tenant has received no
notice of prior sale, transfer, assignment, hypothecation or pledge of the Lease or of the rents payable thereunder[, except [            ]]. 

8. [Tenant has the following expansion rights or options for the Property:
[            ]. [Tenant has no rights or options to purchase the Property.] 

9. To the best of Tenant’s knowledge, no hazardous wastes have been generated, treated, stored or disposed of by or on behalf of Tenant
in, on or around the Premises or the Project in violation of any environmental laws. 
 10. The undersigned has executed this Estoppel
Certificate with the knowledge and understanding that [INSERT NAME OF LANDLORD, PURCHASER OR LENDER, AS APPROPRIATE] or its assignee is acquiring the Property in reliance on this certificate and that the undersigned shall be bound by this
certificate. The statements contained herein may be relied upon by [INSERT NAME OF PURCHASER OR LENDER, AS APPROPRIATE], BMR-530 Fairview Avenue LLC, BioMed Realty, L.P., BioMed Realty Trust, Inc., and any
mortgagee of the Property and their respective successors and assigns. 
 Any capitalized terms not defined herein shall have the respective
meanings given in the Lease. 
 Dated this [    ] day of [            ],
20[    ]. 
  

			
	NANOSTRING TECHNOLOGIES, INC.,
	a Delaware corporation
		
	By:		  

	Name:		  

	Title:		  

  
 E-2 

 EXHIBIT F 

[INTENTIONALLY DELETED] 

 EXHIBIT G 

WORK LETTER 
 This
Work Letter (the “Work Letter”) is made and entered into as of the 19th day of October, 2007, by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company
(“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation (“Tenant”), and is attached to and made a part of that certain Lease dated as of October 19, 2007 (the “Lease”), by and
between Landlord and Tenant for the Premises located at 530 Fairview Avenue in Seattle, Washington. All capitalized terms used but not otherwise defined herein shall have the meanings given them in the Lease. 

1. General Requirements. 
 1.1
Tenant’s Authorized Representative. Tenant designates Wayne Burns (“Tenant’s Authorized Representative”) as the person authorized to initial all plans, drawings, changes orders and approvals pursuant to this Work
Letter. Landlord shall not be obligated to respond to or act upon any such item until such item has been initialed by Tenant’s Authorized Representative. 

1.2 Core and Shell Work Schedule. The schedule for the design and development of Core and Shell Work (as defined in the Lease),
including, without limitation, the time periods for preparation and review of construction documents, approvals and performance, shall be in accordance with that certain schedule prepared by Landlord and Tenant attached as Exhibit A-1 to this Work Letter (the “Core and Shell Work Schedule”). The Core and Shell Work Schedule shall be subject to adjustment as mutually agreed upon in writing by the parties,
or as provided in this Work Letter. 
 1.3 Tenant Improvements Schedule. The schedule for the design and development of Tenant
Improvements (as defined in the Lease), including, without limitation, the time periods for preparation and review of construction documents, approvals and performance, shall be in accordance with that certain schedule prepared by Landlord and
Tenant attached as Exhibit A-2 to this Work Letter (the “Tenant Improvements Schedule”). The Tenant Improvements Schedule shall be subject to adjustment as mutually agreed
upon in writing by the parties, or as provided in this Work Letter. 
 1.4 Architects and Consultants. The architect, engineering
consultants, design team, general contractor and subcontractors responsible for the construction of Landlord’s Work shall be selected by Landlord and approved by Tenant, which approval Tenant shall not unreasonably withhold, condition or delay.
Tenant hereby approves of Mithun Incorporated as Landlord’s architect and M.A. Mortenson Company as Landlord’s general contractor for the Core and Shell Work. 

1.5 Construction Management Fee. Tenant shall pay Landlord a construction management fee in exchange for Landlord’s performance of
the Tenant Improvements pursuant to Section 3 hereof equal to the lesser of (a) three percent (3%) of the TI Costs, and (b) Forty Thousand Dollars ($40,000) (the “Construction Management Fee”). 

  
 G-1 

 2. Core and Shell Work. 

2.1 Core and Shell Work. Core and Shell Work shall be performed by Landlord at Landlord’s sole cost and expense in accordance with
the Approved Core and Shell Plans (as defined below) and the Core and Shell Work Schedule, subject only to changes approved in accordance with Section 2.3. 

2.2 Approved Core and Shell Plans. Landlord shall prepare final plans and specifications for Core and Shell Work that are:
(a) consistent with and are logical evolutions of the Design Development Drawings attached as Exhibit B which have been approved by the parties, (b) incorporate Core and Shell Permitted Changes, and (c) incorporate any
other Landlord-requested Core and Shell Changes that do not materially adversely impact Tenant (provided that if any such change increases Tenant’s costs, the same shall be borne by Landlord). As soon as such final plans and
specifications (“Final Core and Shell Plans”) are completed, Landlord shall deliver the same to Tenant for Tenant’s approval, which approval may be withheld only if: (i) the Final Core and Shell Plans are not consistent
with or logical evolutions of the approved Design Development Drawings, (ii) Tenant requests changes to the Final Core and Shell Plans in accordance with Section 2.3(a)(i), or (iii) Tenant objects to any Landlord requested Core
and Shell Change (other than Core and Shell Permitted Changes). Such Final Core and Shell Plans shall be approved or disapproved by Tenant within ten (10) days after delivery to Tenant. Tenant shall not unreasonably withhold its approval of the
Final Core and Shell Plans. If Tenant fails to notify Landlord of disapproval within this ten (10) day period, then the Final Core and Shell Plans shall be deemed approved. If the Final Core and Shell Plans are disapproved by Tenant, Tenant
shall notify Landlord in writing of its objections to such Final Core and Shell Plans and shall submit any requested Core and Shell Changes through a Core and Shell Tenant Change Order Request (as defined below), and the parties shall confer and
negotiate in good faith to reach agreement on the Final Core and Shell Plans. Promptly after the Final Core and Shell Plans are approved by Landlord and Tenant, two (2) copies of such Final Core and Shell Plans shall be initialed and dated by
Landlord and Tenant as soon as approved by Landlord and Tenant, Landlord shall promptly submit such Final Core and Shell Plans to all appropriate governmental agencies for approval. The Final Core and Shell Plans so approved, and all change orders
specifically permitted by this Agreement, are referred to herein as the “Approved Core and Shell Plans” and shall become part of this Lease as though set forth in full. 

  
 G-2 

 2.3 Changes to Core and Shell Work. Any changes to the Final Core and Shell Plans or the
Approved Core and Shell Plans (each, a “Core and Shell Change”) requested by Landlord or Tenant (other than Core and Shell Permitted Changes made by Landlord) shall be requested and instituted in accordance with the provisions of this
Article 2 and shall be subject to the written approval of the other party in accordance with this Work Letter. 
 (a) Core
and Shell Changes Requested by Tenant. 
 (i) Core and Shell Tenant Change Order Request. Tenant may request Core and Shell
Changes to the Final Core and Shell Plans or the Approved Core and Shell Plans by notifying Landlord thereof in writing in substantially the same form as the AIA standard change order form (a “Core and Shell Tenant Change Order
Request”), which Core and Shell Tenant Change Order Request shall detail the nature and extent of any requested Core and Shell Changes, including, without limitation, (a) the Core and Shell Change, (b) the party required to
perform the Core and Shell Change, and (c) any modification of the Final Core and Shell Plans or the Approved Core and Shell Plans, as applicable, and the Core and Shell Work Schedule necessitated by the Core and Shell Change. If the
nature of a Core and Shell Change required by Tenant requires revisions to the Final Core and Shell Plans or the Approved Core and Shell Plans, as applicable, or the Core and Shell Work Schedule, then Tenant shall be solely responsible for the cost
and expense of such revisions and all additional costs or expenses incurred by Landlord to complete the Core and Shell Work (collectively, the “Tenant Core and Shell Costs”), which Tenant may elect to pay out of the TI Allowance. If
the estimated increase in TI Costs that results from such Core and Shell Change causes the estimated TI Costs to exceed the TI Allowance, Tenant shall deposit with Landlord the amount of such excess, as reasonably estimated by Landlord, within ten
(10) days of receiving Landlord’s approval of such Core and Shell Change. 
 (ii) Landlord’s Approval of Core and Shell
Changes. If Landlord does not notify Tenant in writing of Landlord’s decision either to approve or disapprove any Tenant requested Core and Shell Change within ten (10) days after receipt of a Core and Shell Tenant Change Order
Request, then such Core and Shell Tenant Change Order Request shall be deemed approved by Landlord, and Tenant shall be permitted to alter Core and Shell Work as contemplated by such Core and Shell Tenant Change Order Request. Landlord may withhold
in it sole and absolute discretion its approval of any Core and Shell Tenant Change Order Request; provided, however, Landlord shall not unreasonably withhold its approval to any Core and Shell Change requested by Tenant that is a Core
and Shell Permitted Change. 
 (b) Changes Requested by Landlord. 

(i) Core and Shell Landlord Change Order Request. Tenant’s consent shall not be required in connection with Core and Shell
Permitted Changes to Core and Shell Work. Other than Core and Shell Permitted Changes, Landlord may request Core and Shell Changes to Core and Shell Work by notifying Tenant thereof in writing in substantially the same form as the AIA standard
change order font! (a “Core and Shell Landlord Change Order Request”), which Core and Shell Landlord Change Order Request shall detail the nature and extent of any requested Core and Shell Changes, including, without limitation,
(a) the Core and Shell Change, (b) the party required to perform the Core and Shell Change, and (c) any modification of the Approved Core and Shell Plans and the Core and Shell Work Schedule necessitated by the Core and Shell
Change. 
 (ii) Tenant’s Approval of Core and Shell Change. Tenant shall have ten (10) days after receipt of a Core and
Shell Landlord Change Order Request to notify Landlord in writing of Tenant’s approval or rejection of the Landlord-requested Core and Shell Change, which approval shall not be unreasonably withheld. Tenant’s failure to respond within such
ten (10) day period shall be deemed approval by Tenant. 

  
 G-3 

 (c) Core and Shell Permitted Changes. For purposes of this Work Letter, a “Core
and Shell Permitted Change” shall mean: (a) minor field changes; (b) changes required by Governmental Authority; (c) any other changes that: (1) do not materially and adversely affect the building structure, roof, or
building service equipment to be constructed as part of Core and Shell Work, and (2) do not materially change the size, cost, configuration, or overall appearance of the Building or Landlord’s ability to construct Core and Shell Work or
Tenant’s ability to operate its business in the Building, or materially and adversely affect the Tenant Improvements or materially increase Tenant’s costs (unless such increase in cost is consented to by Tenant or Landlord elects to pay
such increased costs); and (d) ordinary development of the Approved Core and Shell Plans in a manner not inconsistent with the Approved Core and Shell Plans. 

3. Tenant Improvements. 
 3.1 Work
Plans. The Tenant Improvements, shall be performed by Landlord at Tenant’s sole cost and expense and without cost to Landlord (except for the TI Allowance) and in accordance with the Approved TI Plans (as defined below). The design
drawings, plans and specifications listed on Exhibit C to this Work Letter (the “Tenant Work Plans”) are the initial list of plans that Tenant shall develop and submit to Landlord for approval. Tenant shall prepare and
submit to Landlord for approval (such approval not to be unreasonably withheld, conditioned or delayed) schematics covering the Tenant Improvements prepared in conformity with the applicable provisions of this Work Letter (the “Draft
Plans”). The Draft Plans shall contain sufficient information and detail to accurately describe the proposed design to Landlord and such other information as Landlord may reasonably request. Tenant shall be solely responsible for ensuring
that the Tenant Work Plans and the Draft Plans satisfy Tenant’s obligations for the Tenant Improvements. 
 3.2 Landlord Approval of
Plans. Landlord shall notify Tenant in writing within ten (10) days after receipt of the Draft Plans whether Landlord approves or objects to the Draft Plans and of the manner, if any, in which the Draft Plans are unacceptable. If Landlord
reasonably objects to the Draft Plans, then Tenant shall revise the Draft Plans and cause Landlord’s objections to be remedied in the revised Draft Plans. Tenant shall then resubmit the revised Draft Plans to Landlord for approval.
Landlord’s approval of or objection to revised Draft Plans and Tenant’s correction of the same shall be in accordance with this Section 3.2, until Landlord has approved the Draft Plans in writing. The iteration of the Draft
Plans that is approved by Landlord without objection shall be referred to herein as the “Approved Draft Plans.” 
 3.3
Design Development Plans. Landlord shall prepare design development plans for the Tenant Improvements that: (a) are consistent with and are logical evolutions of the Approved Draft Plans, (b) incorporate TI Permitted Changes, and
(c) incorporate any other Landlord-requested TI Changes that are consented to by Tenant. As soon as such design development plans (the “Design Development Plans”) are completed, Landlord shall deliver the same to Tenant for
Tenant’s approval, which approval may be reasonably withheld only if the Design Development Plans are not consistent with or logical evolutions of the Approved Draft Plans. Such Design Development Plans

  
 G-4 

 
shall be approved or disapproved by Tenant within ten (10) days after delivery to Tenant. If Tenant fails to notify Landlord of disapproval within this ten (10) day period, the Design
Development Plans shall be deemed approved. If the Design Development Plans are disapproved by Tenant, then Tenant shall notify Landlord in writing of its objections to such Design Development Plans and the parties shall confer and negotiate in good
faith to reach agreement on the Design Development Plans. 
 3.4 Approved TI Plans. Landlord shall prepare final plans and
specifications for the Tenant Improvements that: (a) are consistent with and are logical evolutions of the Design Development Plans, (b) incorporate TI Permitted Changes, and (c) incorporate any other Landlord-requested TI Changes to
which Tenant consents. As soon as such final plans and specifications (“Final TI Plans”) are completed, Landlord shall deliver the same to Tenant for Tenant’s approval, which approval may be reasonably withheld only if:
(i) the Final TI Plans are not consistent with or logical evolutions of the Design Development Plans, or (ii) Tenant objects to any Landlord requested TI Change (other than TI Permitted Changes). Such Final TI Plans shall be approved or
disapproved by Tenant within ten (10) days after delivery to Tenant. If Tenant fails to notify Landlord of disapproval within this ten (10) day period, the Final TI Plans shall be deemed approved. If the Final TI Plans are disapproved by
Tenant, then Tenant shall notify Landlord in writing of its objections to such Final TI Plans and shall submit any requested TI Changes through a TI Tenant Change Order Request (as defined below), and the parties shall confer and negotiate in good
faith to reach agreement on the Final TI Plans. Promptly after the Final TI Plans are approved by Landlord and Tenant, two (2) copies of such Final TI Plans shall be initialed and dated by Landlord and Tenant as soon as approved by Landlord and
Tenant, Landlord shall promptly submit such Final TI Plans to all appropriate governmental agencies for approval. The Final TI Plans so approved, and all change orders specifically permitted by this Agreement, are referred to herein as the
“Approved TI Plans” and shall become part of this Lease as though set forth in full 
 3.5 Changes to Tenant
Improvements. Any changes to the Final TI Plans or the Approved TI Plans (each, a “TI Change”) requested by Landlord or Tenant (other than TI Permitted Changes made by Landlord) shall be requested and instituted in accordance
with the provisions of this Article 3 and shall be subject to the written approval of the other party in accordance with this Work Letter and the provisions of Article 44 of the Lease. 

(a) TI Changes Requested by Tenant. 

(i) TI Tenant Change Order Request. Tenant may request TI Changes after Tenant approves the Final TI Plans or the Approved TI Plans,
as applicable, by notifying Landlord thereof in writing in substantially the same form as the AIA standard change order form (a “TI Tenant Change Order Request”), which TI Tenant Change Order Request shall detail the nature and
extent of any requested TI Changes, including, without limitation, (a) the TI Change, (b) the party required to perform the TI Change, and (c) any modification of the Final TI Plans or the Approved TI Plans, as applicable, or the
respective Schedule necessitated by the TI Change. If the nature of a TI Change requires revisions to the Final TI Plans or the Approved TI Plans, as applicable, then Tenant shall be solely responsible for the cost and expense of such revisions but

  
 G-5 

 
may apply the TI Allowance to the same. Tenant shall deposit with Landlord the additional cost and expense payable by Landlord, as reasonably estimated by Landlord, to complete the Tenant
Improvements due to a Tenant-requested TI Change within ten (10) days of receiving Landlord’s approval of such TI Change (the “TI Deposit”) if the TI Allowance is exhausted. In the event such deposit is not sufficient to
cover the approved TI Change, Tenant shall reimburse Landlord the difference between the actual cost of such TI Change and the TI Deposit. Tenant shall have the right to apply the Additional Allowance towards the TI Deposit. TI Tenant Change Order
Requests shall be signed by Tenant’s Authorized Representative. 
 (ii) Landlord’s Approval of TI Changes. All
Tenant-requested TI Changes shall be subject to Landlord’s prior written approval, which shall not be unreasonably withheld, conditioned or delayed. Landlord shall have ten (10) days after receipt of a TI Tenant Change Order Request to
notify Tenant in writing of Landlord’s approval or disapproval of any such Tenant-requested TI Change. If Landlord does not disapprove in writing a TI Tenant Change Order Request, then such TI Tenant Change Order Request shall be deemed
approved. 
 (b) TI Changes Requested by Landlord. 

(i) TI Landlord Change Order Request. Tenant’s consent shall not be required in connection with Landlord-requested TI Permitted
Changes to the Tenant Improvements. Other than TI Permitted Changes, Landlord may request TI Changes after Tenant approves the Approved TI Plans by notifying Tenant thereof in writing in substantially the same form as the AIA standard change order
form (a “TI Landlord Change Order Request”), which TI Landlord Change Order Request shall detail the nature and extent of any requested TI Changes, including, without limitation, (a) the TI Change, (b) the party required
to perform the TI Change, and (c) any modification of the Approved TI Plans or the respective Schedule necessitated by the TI Change. If the nature of a TI Change requires revisions to the Approved TI Plans, then Landlord shall be solely
responsible for the cost and expense of such revisions. 
 (ii) Tenant’s Approval of TI Change. Tenant shall have ten
(10) days after receipt of a TI Landlord Change Order Request to notify Landlord in writing of Tenant’s approval or rejection of the Landlord-requested TI Change, which approval shall not be unreasonably withheld, conditioned or delayed.
Tenant’s failure to respond within such ten (10) day period shall be deemed approval by Tenant. 
 (c) TI Permitted
Changes. For purposes of this Work Letter, a “TI Permitted Change” shall mean: (a) minor field changes; (b) changes required by Governmental Authority; (c) any other changes that: (1) do not materially and
adversely affect Tenant’s requirements for the Tenant Improvements or the building structure, roof, or building service equipment to be constructed as part of the Tenant Improvements, and (2) do not materially change the size, cost,
configuration, or overall appearance of the Tenant Improvements or Tenant’s ability to operate its business in the Building or use the Premises for the Permitted Use; and (d) ordinary development of the Approved TI Plans in a manner not
inconsistent with the Approved TI Plans. In no event may Landlord make any change whatsoever to the TI Plans if the same increases Tenant’s costs, unless consented to by Tenant. 

  
 G-6 

 4. Requests for Consent. Except as otherwise provided in this Work Letter, Tenant shall respond to all
requests for consents, approvals or directions made by Landlord pursuant to this Work Letter within (10) days following Tenant’s receipt of such request. Tenant’s failure to respond within such ten (10) day period shall be deemed
approval by Tenant. 
 5. Miscellaneous. 

5.1 Headings, Etc. Where applicable in this Work Letter, the singular includes the plural and the masculine or neuter includes the
masculine, feminine and neuter. The section headings of this Work Letter are not a part of this Work Letter and shall have no effect upon the construction or interpretation of any part hereof. 

5.2 Time of the Essence. Time is of the essence with respect to the performance of every provision of this Work Letter in which time of
performance is a factor. 
 5.3 Covenants. Each provision of this Work Letter performable by Landlord or Tenant shall be deemed both
a covenant and a condition. 
 5.4 Consent. Whenever consent or approval of either party is required, that party shall not
unreasonably withhold such consent or approval, except as may be expressly set forth to the contrary. 
 5.5 Entire Agreement. The
terms of this Work Letter are intended by the parties as a final expression of their agreement with respect to the terms as are included herein, and may not be contradicted by evidence of any prior or contemporaneous agreement, other than the Lease.

 5.6 Invalid Provisions. Any provision of this Work Letter that shall prove to be invalid, void or illegal shall in no way affect,
impair or invalidate any other provision hereof, and all other provisions of this Work Letter shall remain in full force and effect and shall be interpreted as if the invalid, void or illegal provision did not exist. 

5.7 Construction. The language in all parts of this Work Letter shall be in all cases construed as a whole according to its fair
meaning and not strictly for or against either Landlord or Tenant. 
 5.8 Assigns. Each of the covenants, conditions and agreements
herein contained shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs; legatees; devisees; executors; administrators; and permitted successors, assigns, sublessees. Nothing in this
Section 5.8 shall in any way alter the provisions of the Lease restricting assignment or subletting. 
 5.9 Authority.
Each of Tenant and Landlord warrant that the individual or individuals signing this Work Letter on its behalf have the power, authority and legal capacity to sign this Work Letter on behalf of and to bind all entities, corporations, partnerships,
limited liability companies, joint venturers or other organizations and entities on whose behalf said individual or individuals have signed. 

  
 G-7 

 5.10 Counterparts. This Work Letter may be executed in one or more counterparts, each of
which, when taken together, shall constitute one and the same document. 
 IN WITNESS WHEREOF, Landlord and Tenant have executed this Work
Letter to be effective on the date first above written. 
  

			
	LANDLORD:
	
	 BMR-530 FAIRVIEW AVENUE LLC,

a Delaware limited liability company

		
	By:		  

	Name:		  

	Title:		  

	
	TENANT:
	
	 NANOSTRING TECHNOLOGIES, INC.,
 a
Delaware corporation

		
	By:		  

	Name:		  

	Title:		  

  
 G-8 

 EXHIBIT A-1 

CORE AND SHELL WORK SCHEDULE 
  

 

 EXHIBIT A-2 

TENANT IMPROVEMENTS SCHEDULE 
  

 

 EXHIBIT B 

PLANS AND SPECIFICATIONS 
 The
Contract Documents include the following: 
 Geotechnical Report: 

Geotechnical Report by Terra Associates dated November 7, 2005 

Specifications: 
 Fairview Research Center Project
Manual dated 9/22/06 
  
 

 

 

 

 

 

  
 

 

  
 

 

 EXHIBIT C 

TENANT WORK PLANS 

Tenant shall provide a full set of design drawings, plans and specifications as reasonably required by Landlord. 

 EXHIBIT H 

FORM OF LETTER OF CREDIT 

[On letterhead or L/C letterhead of Issuer.] 

LETTER OF CREDIT 
 Date:
            , 200     
  

					
	  
		(the “Beneficiary”)
	  
		
	  
		
	Attention:		  
		
	L/C. No.:		  
		
	Loan No. :		  
		

 Ladies and Gentlemen: 

We establish in favor of Beneficiary our irrevocable and unconditional Letter of Credit numbered as identified above (the
“L/C”) for an aggregate amount of $        , expiring at     :00 p.m. on          or, if such day is not a Banking Day, then the
next succeeding Banking Day (such date, as extended from time to time, the “Expiry Date”). “Banking Day” means a weekday except a weekday when commercial banks in
             are authorized or required to close. 
 We authorize Beneficiary to
draw on us (the “Issuer”) for the account of              (the “Account Party”), under the terms and conditions of this L/C. 

Funds under this L/C are available by presenting the following documentation (the “Drawing Documentation”): (a) the
original L/C and (b) a sight draft substantially in the form of Exhibit A, with blanks filled in and bracketed items provided as appropriate. No other evidence of authority, certificate, or documentation is required. 

Drawing Documentation must be presented at Issuer’s office at
                     on or before the Expiry Date by personal presentation, courier or messenger service, or fax. Presentation by fax shall be
effective upon electronic confirmation of transmission as evidenced by a printed report from the sender’s fax machine. After any fax presentation, but not as a condition to its effectiveness, Beneficiary shall with reasonable promptness deliver
the original Drawing Documentation by any other means. Issuer will on request issue a receipt for Drawing Documentation. 
 We agree,
irrevocably, and irrespective of any claim by any other person, to honor drafts drawn under and in conformity with this L/C, within the maximum amount of this L/C, presented to us on or before the Expiry Date, provided we also receive (on or before
the Expiry Date) any other Drawing Documentation this L/C requires. 

  
 H-1 

 We shall pay this L/C only from our own funds by check or wire transfer, in compliance with the
Drawing Documentation. 
 If Beneficiary presents proper Drawing Documentation to us on or before the Expiry Date, then we shall pay under
this L/C at or before the following time (the “Payment Deadline”): (a) if presentment is made at or before noon of any Banking Day, then the close of such Banking Day; and (b) otherwise, the close of the next Banking Day.
We waive any right to delay payment beyond the Payment Deadline. If we determine that Drawing Documentation is not proper, then we shall so advise Beneficiary in writing, specifying all grounds for our determination, within one Banking Day after the
Payment Deadline. 
 Partial drawings are permitted. This L/C shall, except to the extent reduced thereby, survive any partial drawings.

 We shall have no duty or right to inquire into the validity of or basis for any draw under this L/C or any Drawing Documentation. 

The Expiry Date shall automatically be extended by one year (but never beyond
             the “Outside Date”) unless, on or before the date sixty (60) days before any Expiry Date, we have given Beneficiary notice that the Expiry Date shall not
be so extended (a “Nonrenewal Notice”). We shall promptly upon request confirm any extension of the Expiry Date under the preceding sentence by issuing an amendment to this L/C, but such an amendment is not required for the
extension to be effective. We need not give any notice of the Outside Date. 
 Beneficiary may from time to time without charge transfer
this L/C, in whole but not in part, to any transferee (the “Transferee”). Issuer shall look solely to Account Party for payment of any fee for any transfer of this L/C. Such payment is not a condition to any such transfer.
Beneficiary or Transferee shall consummate such transfer by delivering to Issuer the original of this L/C and a Transfer Notice substantially in the form of Exhibit B, purportedly signed by Beneficiary, and designating Transferee. Issuer
shall promptly reissue or amend this L/C in favor of Transferee as Beneficiary. Upon any transfer, all references to Beneficiary shall automatically refer to Transferee, who may then exercise all rights of Beneficiary. Issuer expressly consents to
any transfers made from time to time in compliance with this paragraph. 
 Any notice to Beneficiary shall be in writing and delivered by
hand with receipt acknowledged or by overnight delivery service such as FedEx (with proof of delivery) at the above address, or such other address as Beneficiary may specify by written notice to Issuer. A copy of any such notice shall also be
delivered, as a condition to the effectiveness of such notice, to:              (or such replacement as Beneficiary designates from time to time by written notice). 

No amendment that adversely affects Beneficiary shall be effective without Beneficiary’s written consent. 

  
 H-2 

 This L/C is subject to and incorporates by reference: (a) the Uniform Customs and Practice
for Documentary Credits, International Chamber of Commerce Publication No. 500 (the “UCP”); and (b) to the extent not inconsistent with the UCP, Article 5 of the Uniform Commercial Code of the State of New
York. 
  

	
	Very truly yours,
	
	[Issuer Signature]

  
 H-3 

 EXHIBIT A 

FORM OF SIGHT DRAFT 
 [BENEFICIARY
LETTERHEAD] 
 TO: 
 [Name and Address of Issuer] 

SIGHT DRAFT 
 AT SIGHT, pay to the Order
of                     , the sum of
                     United States Dollars ($        ). Drawn under [Issuer] Letter of Credit No.
         dated                     . 

[Issuer is hereby directed to pay the proceeds of this Sight Draft solely to the following account:
                            -] 

[Name and signature block, with signature or purported signature of Beneficiary] 
  

			
	Date:		  

  
 H-4 

 EXHIBIT B 

FORM OF TRANSFER NOTICE 

[BENEFICIARY LETTERHEAD] 
 TO: 

[Name and Address of Issuer] (the “Issuer”) 

TRANSFER NOTICE 
 By signing below, the
undersigned, Beneficiary (the “Beneficiary”) under Issuer’s Letter of Credit No.          dated
                     (the “L/C”), transfers the L/C to the following transferee (the “Transferee”): 

[Transferee Name and Address] 
 The original L/C is enclosed.
Beneficiary directs Issuer to reissue or amend the L/C in favor of Transferee as Beneficiary. Beneficiary represents and warrants that Beneficiary has not transferred, assigned, or encumbered the L/C or any interest in the L/C, which transfer,
assignment, or encumbrance remains in effect. 
 [Name and signature block, with signature or purported signature of Beneficiary] 

 

			
	Date:		  

  
 H-5 

 EXHIBIT I 

FORM OF ADDITIONAL TI ALLOWANCE ACCEPTANCE LETTER 

[TENANT LETTERHEAD] 
 BMR-530 Fairview Avenue LLC 
 17140 Bernardo Center Drive, Suite 222 

San Diego, California 92128 
 Attn: General Counsel/Real Estate

 [Date] 
 Re: Additional
Allowance 
 To Whom It May Concern: 

This letter concerns that certain Lease dated as of October 19, 2007 (the “Lease”), between BMR-530 FAIRVIEW AVENUE LLC (“Landlord”) and NANOSTRING TECHNOLOGIES, INC., (“Tenant”). Capitalized terms not otherwise defined herein shall have the meanings given them in the
Lease. 
 Tenant hereby notifies Landlord that it wishes to exercise its right to utilize $        
of the Additional Allowance pursuant to Section 4.2.3 of the Lease. 
 If you have any questions, please do not hesitate to call
[            ] at ([            ])
[            ]-[            ] 
  

	
	Sincerely,
	
	[Name]
	[Title of Authorized Signatory]

  

			
	Cc:		Greg Lubushkin
			John Wilson
			Kevin Simonsen

  
 I-1 

 EXHIBIT J 

FORM OF HOLDOVER SIDE LETTER 

  
 J-1 

 BMR-201 Elliott Avenue LLC 

17140 Bernardo Center Drive, Suite 222 

San Diego, California 92128 
 Phone:
(858) 485-9840 
 Facsimile: (858) 485-9843 

October 19, 2007 
 Nanostring Technologies,
Inc. 
 201 Elliott Ave, W. Suite 300 
 Seattle, Washington
98119 
 Attn: Wayne Burns 
 Re: Leases for
Fairview Research Center and 201 Elliott Avenue 
 Dear Mr. Burns: 

This letter agreement is written in connection with (a) that certain lease dated as of the date hereof for the building to be constructed
at 530 Fairview Avenue, Seattle, Washington (the “New Building Lease”) by and between BMR-530 Fairview Avenue LLC, as landlord (“Landlord”), and Nanostring Technologies, Inc., as tenant
(“Tenant”), (b) that certain Lease Agreement (the “Existing Master Lease”) dated August 20, 2002 by and between BMR¬201 Elliott Avenue LLC
(successor-in-interest to Elliott Park LLC), as landlord (“Master Landlord”) and Cell Therapeutics, Inc., as tenant (“Cell Therapeutics”), and
(c) that certain Sublease (the “Existing Sublease”) dated as of October 6, 2004, as amended, and Service Agreement (“Service Agreement) with an effective date of October 15, 2004, both by and between Cell Therapeutics,
as sublessor, and Tenant, as sublessee. 
 Master Landlord currently leases certain space on the first, third, fourth and fifth floors of
the building (the “Building”) located at 201 Elliott Avenue, W. Suite 300, Seattle, Washington (the “Master Leased Premises”) to Cell Therapeutics pursuant to the Master Lease, and Cell Therapeutics currently subleases a certain
portion of the Master Leased Premises located on the third floor of such building (the “Existing Premises”) to Nanostring Technologies, Inc. pursuant to the Existing Sublease. Pursuant to the Existing Master Lease and the Existing
Sublease, the Existing Master Lease and the Existing Sublease will expire on January 31, 2008 (the “Existing Lease Expiration Date”). 

Notwithstanding the foregoing, and in consideration of Tenant’s entering into the New Building Lease (Master Landlord acknowledges that
it will receive a direct or indirect benefit from Tenant’s entering into the New Building Lease), Master Landlord shall permit Tenant to continue to occupy and use the Existing Premises for the time period (such time period being referred to
herein as the “Gap Period”) beginning on the Existing Lease Expiration Date and ending on the “Term Commencement Date” (as such term is defined in, and may be adjusted under, the New Building Lease) on the same terms and
conditions as the Existing Sublease (as if the Existing Sublease were a direct lease between Tenant and Master Landlord); provided, however, that Tenant shall not be 

 
obligated to pay any Base Rent (as such term is defined in the Existing Sublease) for the Gap Period; provided, further, if the New Building Lease terminates before the Term Commencement Date,
then Tenant’s right to occupy the Existing Premises shall terminate effective on the later of (a) fifteen days after the New Building Lease terminates or (b) the Existing Lease Expiration Date; provided that if such termination is
primarily due to Landlord’s default or breach of the New Building Lease, then such right of Tenant to occupy the Existing Premises shall terminate on the date that is twelve (12) months after the date of termination of the New Building
Lease. For the avoidance of doubt, the parties agree that Tenant shall remain obligated during the Gap Period to perform the following obligations, among other obligations, as set forth in the Sublease (except that such obligations shall be
performed for the benefit of Master Landlord rather than Cell Therapeutics): (i) to pay Tenant’s pro rata share of all Taxes and Operating Costs (as such terms are defined in the Existing Sublease) for the Existing Premises (with the
exception of any Taxes or Operating Costs for the Existing Premises directly or indirectly and primarily attributable to Master Landlord’s planned improvements to the Existing Premises) as required by Section 2.3 of the Existing Sublease
during the Gap Period (except that Tenant should pay such amounts to Landlord rather than Cell Therapeutics), (ii) to maintain the insurance required by Section 5.4 of the Existing Sublease and (iii) to satisfy any other obligations
under the Existing Sublease related to Tenant’s occupancy of the Existing Premises during the Gap Period. Similarly, during the Gap Period, Master Landlord shall continue to provide for the benefit of Tenant rather than Cell Therapeutics all
services that Master Landlord is required to provide to Cell Therapeutics under the Existing Master Lease with respect to the Existing Premises (as if the time of the Master Lease were extended for the Gap Period), and Tenant shall enjoy and be
entitled to all of the benefits and rights to which Cell Therapeutics is entitled under the Existing Master Lease (as if the term of the Master Lease were extended for the Gap Period), including without limitation (i) all rights and protections
benefiting the tenant under Section 6 of the Existing Master Lease; (ii) all services and utilities as required by Section 7 of the Existing Master Lease (including without limitation the provision of electrical, water, HVAC,
janitorial and security services), (iii) the audit right set forth in Section 8.4 of the Existing Master Lease, (iv) the waiver of subrogation set forth in Section 12 of the Existing Master Lease, (v) the indemnification
provisions of Section 13 of the Existing Master Lease, (vi) the default and remedy provisions of Section 19.10 of the Existing Master Lease, and (vii) parking spaces as required by Section 29 of the Existing Master Lease.

 The parties further understand, agree and acknowledge that Master Landlord may make certain improvements to the Building (other than the
Existing Premises) during the Gap Period (the “Improvements”), and that the nature of the Improvements may interfere with Tenant’s use of the Existing Premises as permitted by the terms of the Existing Sublease, including through the
introduction of noise, vibration and dirt into the Existing Premises; provided, however, Master Landlord shall not unnecessarily disturb Tenant’s access to the Existing Premises. Tenant knowingly and voluntarily assumes the risk
of, and agrees that Master Landlord shall not be liable to Tenant for, any consequential or other damages arising in connection with the Improvements, and Tenant further waives any claim for injury, loss of income or other damages relating to the
Improvements. Landlord will endeavor to keep Tenant informed of the progress of the Improvements to the extent they may interfere with Landlord’s operations and to reasonably cooperate with Tenant to avoid unnecessary disruption to
Tenant’s operations. 

 So long as Tenant is not in default beyond applicable notice and cure periods under the Existing
Sublease, Tenant’s peaceable and quiet enjoyment of the Existing Premises shall not be disturbed by Master Landlord or anyone claiming by or through Master Landlord. 

Notwithstanding anything to the contrary, upon the expiration of the Gap Period, Tenant shall surrender the Existing Premises to Landlord in
its as-is condition, without any obligation to remove or restore any improvements or alterations to the Existing Premises. Tenant shall be entitled to remove any equipment, fixtures or trade fixtures from the
Existing Premises at Tenant’s election. At least ten (10) days prior to Tenant’s surrender of possession of the Existing Premises, Tenant shall provide Landlord with a facility decommissioning report for the Existing Premises
(“Exit Survey”) in order to verify that Tenant has left the Existing Premises free of environmental conditions in violation of applicable laws. Tenant agrees to remain responsible after the surrender of the Existing Premises for the
remediation of any environmental conditions in the Existing Premises in violation of law that are set forth in the Exit Survey as well as compliance with any reasonable recommendations set forth in the Exit Survey. However, notwithstanding the
foregoing, Tenant shall not be responsible for environmental conditions in the Existing Premises that were not caused by Tenant or Tenant’s agents, contractors or employees. Tenant’s obligations under this paragraph shall survive the
expiration or earlier termination of the New Building Lease or this letter agreement. 
 If legal proceedings are initiated to enforce any
term of this letter agreement or for the breach of any covenant or condition of this letter agreement, the prevailing party shall be entitled to recover reasonable attorneys’ fees and costs of suit to be fixed by the court. 

Please cause an authorized representative of Tenant to execute this Letter Agreement in the place provided below to indicate Tenant’s
agreement with the terms and conditions set forth herein. 
  

			
	Very truly yours,
	
	 BMR-201 ELLIOTT AVENUE LLC,
 a
Delaware limited liability, company

		
	By:		 /s/ Kent Griffin

	Name:		 Kent Griffin

	Title:		 CFO

  

			
	ACCEPTED AND AGREED:
	
	 NANOSTRING TECHNOLOGIES, INC.
 a
Delaware corporation

		
	By:		 /s/ Wayne Burns

	Name:		 Wayne Burns

	Title:		 CFO

  

			
	cc:		Steven Levine, Esq.
			Kevin Simonsen
			Chris Elmendorf

 EXHIBIT K 

[INTENTIONALLY DELETED] 

 EXHIBIT L 

WARM SHELL WORK 
  

	
	 Roofing

	Miscellaneous roofing as needed
	Walkway pads to base building mechanical equipment
	 Common Areas

	Finished first floor lobby
	Parking level 1 restroom/shower and janitor closet
	Finished exit stairways
	 Tenant Areas

	Rated shafts per plans
	 Plumbing

	Sanitary waste system and risers tee’d and capped at each floor
	Domestic water distribution - a domestic water riser will be provided with a T connection that will be valved and capped to each floor
	Lab water distribution - Lab hot and cold water systems will be provided with a T connection that will be valved and capped to each floor.
	 Gas

	Gas riser to penthouse
	 H.V.A.C

	Central HVAC system providing 100% outside air for tenant use. A base design of 1 CFM/sf to support lab or office use is available to each floor.
	Exhaust capacity for common areas & toilets per code
	Exhaust capacity for office and lab
	Supply and exhaust duct risers provided
	Hydronic systems - Hot and cold hydronic connections will be provided with a T connection that will be valved and capped to each floor.
	Automatic temperature control system - Building Management System is installed for the base building systems
	Network communication riser provided for tenant access to Building Management System
	 Electrical

	400 amp 480/277 Volt panel is provided on each floor.
	Electrical closets on tenant floors
	A central fire alarm system is provided with a connection J-box at each floor for tenant use
	Empty telephone/data conduits from telecom room distributed to each floor
	 Security

	Card access at bldg entries and w/in elevators, and stairwells
	Security system for base bldg area

 Many of the warm shell improvements identified above are illustrated in the sets of plans from Mithun Architects, entitled
Warm Shell Revision dated August 6, 2007. Tenant shall have access to said plans upon request. 
 Landlord may include other improvements (“Warm
Shell Additions”), not described above, in the Warm Shell Work, so long as the Warm Shell Additions are (i) of common service to all floors in the building and (ii) do not exceed, in the aggregate, a cost of $5.00 per rentable square
foot of the building. 

 FIRST AMENDMENT TO LEASE 

THIS FIRST AMENDMENT TO LEASE (this “Amendment”) is entered into as of this
21st day of May, 2009, by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING
TECHNOLOGIES, INC. (“Tenant”). 
 RECITALS 

A. WHEREAS, Landlord and Tenant entered into that certain Lease dated as of October 19, 2007 (as the same may have been amended,
supplemented or otherwise modified from time to time, the “Lease”), whereby Tenant leases certain premises (the “Premises”) from Landlord at 530 Fairview Avenue in Seattle, Washington (the
“Building”); and 
 B. WHEREAS, Landlord and Tenant desire to modify and amend the Lease only in the respects and on the
conditions hereinafter stated. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions.
For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Lease unless otherwise defined herein. The Lease, as amended by this Amendment, shall be referred to herein as the “Amended Lease.”

 2. Sales Tax. 
 a.
Retail sales tax otherwise applicable to portions of construction of the Building and Tenant Improvements and other improvements made or requested by Tenant may be eligible for deferral pursuant to RCW 82.63 (the “Sales Tax
Deferral”) as a result of the uses of the Premises intended by Tenant. Landlord shall make application with the Washington State Department of Revenue (the “State”) for the Sales Tax Deferral with respect to work to be
performed and paid for by Landlord pursuant to the Amended Lease. When the State has determined the final amount of the sales tax which Landlord may defer pursuant to the Sales Tax Deferral Program, Landlord will provide Tenant with written notice
of such amount. 
 b. Tenant agrees if a subsequent audit by the State determines that (a) because Tenant’s use of the Premises
has changed or (b) for any other reason, any of the sales tax previously deferred pursuant to the Sales Tax Deferral is now due and owing to the State, then Tenant shall pay to Landlord, within ten (10) days following the date Landlord
notifies Tenant of any such determination by the State, an amount equal to the amount required to be paid to the State, including any penalties and interest due to the State; provided that Tenant may conduct a good faith contest of any such
determination by the State in accordance with appropriate administrative procedures so long as payment of the amount claimed by the State is stayed during the conduct of the contest. If Tenant desires to dispute the amount claimed by the

 

 
  

 SECOND AMENDMENT TO LEASE 

THIS SECOND AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 16 day of June, 2010, by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
WHEREAS, Landlord and Tenant entered into that certain Lease dated as of October 19, 2007, as amended by that certain First Amendment to Lease dated as of May 21, 2009 (collectively, the “Lease”), whereby Tenant leases
certain premises from Landlord at 530 Fairview Avenue in Seattle, Washington (the “Building”); 
 B. WHEREAS, Tenant
received from Landlord a Notice of Offer pursuant to Article 43 of the Lease and elected to exercise its Right of First Refusal with respect to the Available Premises (as defined in the Lease) on the first floor of the Building, subject
to the modification of such Notice of Offer pursuant to the terms and conditions provided herein; and 
 C. WHEREAS, Tenant desires to lease
from Landlord and Landlord desires to lease to Tenant the 1st Floor Premises (as defined below); and 
 D. WHEREAS, Landlord and Tenant
desire to modify and amend the Lease only in the respects and on the conditions hereinafter stated. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions.
For purposes of this Second Amendment, capitalized terms shall have the meanings ascribed to them in the Lease unless otherwise defined herein. 

2. Original Premises. Pursuant to Section 9.5 of the Lease, Landlord has made a reconciliation measurement of the Original
Premises and the parties acknowledge and agree that the Original Premises contain seventeen thousand seven hundred fifty-six (17,756) square feet of Rentable Area. The foregoing total rentable area of the
Original Premises includes a nine hundred four (904) square foot increase to the Rentable Area of the Original Premises. Landlord and Tenant acknowledge that Landlord’s obligation to expend the TI Allowance has expired and therefore shall
not be adjusted in accordance with the reconciliation measurement of the Premises. 
 3. 1st Floor Premises. Effective as of the 1st
Floor Premises Commencement Date (as defined below), Landlord hereby leases to Tenant and Tenant hereby leases from Landlord approximately five thousand six hundred seventy-seven (5,677) square feet of Rentable Area, located on the first floor
of the Building as shown on Exhibit A attached hereto (the “1st Floor Premises”), but during the Interim Term, Tenant shall pay Basic Annual Rent and Tenant’s Pro

  
 BMR form dated 8/21/09

 CALIFORNIA ALL-PURPOSE 

CERTIFICATE OF ACKNOWLEDGMENT 
 State of
California 
 County of San Diego 
 On Feb. 8, 2011 before me,
Christy Bartlett, Notary Public 
 (Here insert name and title of the officer) 

personally appeared Kevin Simonsen 
 who proved to me on the
basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by his/her /their signature(s)
on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 
 I certify under PENALTY OF PERJURY
under the laws of the State of California that the foregoing paragraph is true and correct. 
  

					
	WITNESS my hand and official seal.	 		 	 

	/s/ Christy D. Bartlett	 		 
	Signature of Notary Public	 		 	(Notary Seal)

  
  

ADDITIONAL OPTIONAL INFORMATION 

 

	
	  

DESCRIPTION OF THE ATTACHED DOCUMENT

 

(Title or description of attached document)

 
 (Title or description of attached document
continued)
  
 Number of Pages     
Document Date                                 

 
 (Additional information)

 

 

CAPACITY CLAIMED BY THE SIGNER 
  

	 	 ̈	Individual (s) 

  

	 	 ̈	Corporate Officer 

 _________________ 

                    
    (Title) 
  

	 	 ̈	Partner(s) 

  

	 	 ̈	Attorney-in-Fact 

  

	 	 ̈	Trustee(s) 

  

	 	 ̈	Other
                                         
    

 

 INSTRUCTIONS FOR COMPLETING THIS FORM 

Any acknowledgment completed in California must contain verbiage exactly as appears above in the notary section or a separate acknowledgment form must be
properly completed and attached to that document. The only exception is if a document is to be recorded outside of California. In such instances, any alternative acknowledgment verbiage as may be printed on such a document so long as the verbiage
does not require the notary to do something that is illegal for a notary in California (i.e. certifying the authorized capacity of the signer). Please check the document carefully for proper notarial wording and attach this form if required.

  

	 	•	 	State and County information must be the State and County where the document signer(s) personally appeared before the notary public for acknowledgment. 

	 	•	 	Date of notarization must be the date that the signer(s) personally appeared which must also be the same date the acknowledgment is completed. 

	 	•	 	The notary public must print his or her name as it appears within his or her commission followed by a comma and then your title (notary public). 

	 	•	 	Print the name(s) of document signer(s) who personally appear at the time of notarization. 

	 	•	 	Indicate the correct singular or plural forms by crossing off incorrect forms (i.e. he/she/they, is /are) or circling the correct forms. Failure to correctly indicate this information may lead to rejection of document
recording. 

	 	•	 	The notary seal impression must be clear and photographically reproducible. Impression must not cover text or lines. If seal impression smudges, re-seal if a sufficient area permits, otherwise complete a different
acknowledgment form. 

	 	•	 	Signature of the notary public must match the signature on file with the office of the county clerk. 

	 	v	Additional information is not required but could help to ensure this acknowledgment is not misused or attached to a different document. 

	 	v	Indicate title or type of attached document, number of pages and date. 

	 	v	Indicate the capacity claimed by the signer. If the claimed capacity is a corporate officer, indicate the title (i.e. CEO, CFO, Secretary). 

	 	•	 	Securely attach this document to the signed document 

 

 THIRD AMENDMENT TO LEASE 

THIS THIRD AMENDMENT TO LEASE (this “Amendment”) is entered into as of this
4th day of February, 2011 (the “Execution Date”), by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company
(“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation (“Tenant”). 
 RECITALS

 A. WHEREAS, Landlord and Tenant entered into that certain Lease dated as of October 19, 2007 (the “Original
Lease”), as amended by that certain First Amendment to Lease dated as of May 21, 2009 (the “First Amendment”), and that certain Second Amendment to Lease dated as of June 16, 2010 (collectively, and as the same
may have been further amended, supplemented or modified from time to time, the “Lease”), whereby Tenant leases certain premises (the “Original Premises”) from Landlord at 530 Fairview Avenue in Seattle, Washington
(the “Building”); 
 B. WHEREAS, Landlord desires to lease additional premises to Tenant; 

C. WHEREAS, Landlord and Tenant desire to extend the Term; 

D. WHEREAS, Tenant desires to surrender the 1st Floor Premises; and 

E. WHEREAS, Landlord and Tenant desire to modify and amend the Lease only in the respects and on the conditions hereinafter stated. 

AGREEMENT 
 NOW,
THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as
follows: 
 1. Definitions. For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Lease unless otherwise
defined herein. The Lease, as modified by this Amendment, is referred to herein as the “Amended Lease.” 
 2. 3rd Floor Premises. Effective as of the dates specified in Section 5 below (the “Commencement Dates”), Landlord leases to Tenant and Tenant leases from Landlord eighteen
thousand five hundred twelve (18,512) square feet of Rentable Area, consisting of the entire 3rd floor of the Building, as depicted on Exhibit A attached hereto (the “3rd Floor Premises”). From and after each Commencement Date, the term “Premises,” as used in the Amended Lease, shall mean the Original Premises (subject to deletion of the 1st Floor Premises pursuant to Section 8 below) plus the applicable portion(s) of the 3rd Floor Premises. For the sake of clarity,
(a) Tenant shall be entitled to lease from Landlord on a monthly basis from time to time throughout the Term (as extended hereby) up to one (1) parking space (located in the Building garage) per one thousand (1,000) square feet of
Rentable Area of the 3rd Floor Premises, in accordance with Section 16.2 of the Original Lease, and (b) the Option shall apply to all Premises then leased pursuant to the Amended
Lease. 

  
 BMR form dated 12/21/10

  
 

 

 FOURTH AMENDMENT TO LEASE 

THIS FOURTH AMENDMENT TO LEASE (this “Fourth Amendment”) is entered into as of this 28th day of May, 2012, by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING TECHNOLOGIES,
INC., a Delaware corporation (“Tenant”). 
 RECITALS 

A. WHEREAS, Landlord and Tenant entered into that certain Lease dated as of October 19, 2007 (the “Original Lease”), as
amended by that certain First Amendment to Lease dated as of May 21, 2009 (the “First Amendment”), that certain Second Amendment to Lease dated as of June 16, 2010 (the “Second Amendment”) and that certain
Third Amendment to Lease dated as of February 4, 2011 (the “Third Amendment,” and together with the Original Lease, First Amendment and Second Amendment, and as the same may have been further amended, amended and restated,
supplemented or modified from time to time, the “Lease”), whereby Tenant leases certain premises (the “Premises”) from Landlord at 530 Fairview Avenue in Seattle, Washington (the “Building”); 

B. WHEREAS, the “Premises” currently consist of approximately twenty-eight thousand five hundred sixty-seven (28,567) square
feet of Rentable Area, comprised of the following spaces: (i) approximately seventeen thousand seven hundred fifty-six (17,756) square feet of Rentable Area, which is the entire second (2nd) floor of the Building (the “Original Premises”), (ii) storage rooms 107 and 109 which are located on the first
(1st) floor of the building (the “Storage Rooms”), but the square footage of such Storage Rooms is not included in the Rentable Area of the Premises, and
(iii) approximately ten thousand eight hundred eleven (10,811) square feet of Rentable Area located on the third (3rd) floor of the Building (the “3rd Floor Premises Phase 1”); 
 C. WHEREAS, Tenant has leased additional space from
Landlord which shall be included as part of the “Premises” but the term of which has not yet commenced: (i) approximately four thousand twenty-eight (4,028) square feet of Rentable Area located on the third (3rd) floor of the Building (the “3rd Floor Premises Phase 2”), the term of which shall commence on August 12, 2012 and
(ii) approximately three thousand six hundred seventy-three (3,673) square feet of Rentable Area located on the third (3rd) floor of the Building (the 443rd Floor Premises Phase
3”), the term of which shall commence on February 12, 2013. The 3rd Floor Premises Phase 1, the 3rd Floor Premises Phase 2 and
the 3rd Floor Premises Phase 3 are collectively referred to as the “3rd Floor Premises”; 

D. WHEREAS, Tenant desires to lease from Landlord and Landlord desires to lease to Tenant approximately six hundred seventeen
(617) square feet of space located in the basement of the Building, as shown on Exhibit A attached hereto (the “Basement Storage Premises”); and 

E. WHEREAS, Landlord and Tenant desire to modify and amend the Lease only in the respects and on the conditions hereinafter stated. 

  
 BMR form dated 10/12/11

 IN WITNESS WHEREOF, Tenant has executed this Acknowledgment of Basement Storage Premises
Commencement Date and Term Expiration Date as of the date first written above. 
  

			
	TENANT:
	
	 NANOSTRING TECHNOLOGIES, INC.,
 a
Delaware corporation

		
	By:		  

	Name:		  

	Title:		  

  
 C-3 

 FIFTH AMENDMENT TO LEASE 

THIS FIFTH AMENDMENT TO LEASE (this “Fifth Amendment”) is entered into as of this 9th day of July, 2013, by and between
BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
WHEREAS, Landlord and Tenant entered into that certain Lease dated as of October 19, 2007 (the “Original Lease”), as amended by that certain First Amendment to Lease dated as of May 21, 2009, that certain Second Amendment
to Lease dated as of June 16, 2010 (the “Second Amendment”), that certain Third Amendment to Lease dated as of February 4, 2011 (the “Third Amendment”) and that certain Fourth Amendment to Lease dated as
of May 31, 2012 (the “Fourth Amendment,” and together with the Original Lease, First Amendment, Second Amendment and Third Amendment, and, collectively, as the same may have been heretofore further amended, amended and
restated, supplemented or modified from time to time, the “Lease”), whereby Tenant leases certain premises (the “Premises”) from Landlord at 530 Fairview Avenue in Seattle, Washington (the
“Building”); 
 B. WHEREAS, Landlord desires to allow Tenant the ability to use a portion of the remaining 3rd Floor
TI Allowance notwithstanding the fact that the deadline to use such funds has expired; and 
 C. WHEREAS, Landlord and Tenant desire to
modify and amend the Lease only in the respects and on the conditions hereinafter stated. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions.
For purposes of this Fifth Amendment, capitalized terms shall have the meanings ascribed to them in the Lease unless otherwise defined herein. The Lease, as amended by this Fifth Amendment, is referred to herein as the “Amended
Lease.” 
 2. 3rd Floor TI Allowance. Tenant desires to install a cooling unit in Tenant’s server room within the
Premises on the second floor of the Building (the “Cooling Unit Work”) and desires to use a portion of the 3rd Floor TI Allowance to perform the Cooling Unit Work. Landlord and Tenant acknowledge that, pursuant to the Work Letter
attached as Exhibit C to the Third Amendment (the “Third Amendment Work Letter”) and Section 6.1 of the Third Amendment, the deadline for Tenant to apply for any portion of the 3rd Floor TI Allowance has passed.
Notwithstanding the foregoing, Tenant shall have until July 31, 2013 to submit an Advance Request (as defined in the Third Amendment Work Letter), along with all other documentation required by Section 6.3 of the Third Amendment
Work Letter, to apply for up to Twenty Thousand Seven 

  
 -10- 

 
Hundred Seventeen and 40/100 Dollars ($20,717.40) only (the “Cooling Unit Work Amount”) of the unused 3rd Floor TI Allowance for costs incurred in performance of the Cooling
Unit Work; provided, however, that the Cooling Unit Work shall constitute Tis (as defined in Section 4.2 of the Third Amendment) and shall be performed by Tenant pursuant to and in accordance with the Third Amendment Work Letter
and Article 4 of the Third Amendment. If Tenant has not submitted an Advance Request, along with all other documentation required by Section 6.3 of the Third Amendment Work Letter, for any portion of the Cooling Unit Work Amount
by July 31, 2013, Landlord’s obligation to fund such costs shall expire. In no event shall any unused 3rd Floor TI Allowance (including the Cooling Unit Work Amount) entitle Tenant to a credit against Rent payable under the Amended Lease.
Subject to the modifications in this Section, any disbursement by Landlord of the Cooling Unit Work Amount shall be subject to and governed by the Third Amendment Work Letter and Article 4 of the Third Amendment (for purposes of clarity,
the Cooling Unit Work Amount shall constitute part of the 3rd Floor TI Allowance). 
 3. Authorized Representative. Landlord’s
Authorized Representative, as defined in Section 1.1(a) of the Third Amendment Work Letter, is hereby amended to mean (a) Mike Ruhl as the person authorized to initial plans, drawings and approvals and to sign change orders pursuant
to the Third Amendment Work Letter and (b) an officer of Landlord as the person authorized to sign any amendments to the Third Amendment Work Letter or the Amended Lease. 

4. Broker. Tenant represents and warrants that it has not dealt with any broker or agent in the negotiation for or the obtaining of
this Fifth Amendment and agrees to indemnify, defend and hold Landlord harmless from any and all cost or liability for compensation claimed by any such broker or agent employed or engaged by it or claiming to have been employed or engaged by it.

 5. No Default. Tenant represents, warrants and covenants that, to the best of Tenant’s knowledge, Landlord and Tenant are not
in default of any of their respective obligations under the Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by either Landlord or Tenant thereunder. 

6. Notices. Tenant confirms that, notwithstanding anything in the Lease to the contrary, notices delivered to Tenant pursuant to the
Amended Lease should be sent to: 
 Nanostring Technologies, Inc. 

Suite 2000 

530 Fairview Avenue 

Seattle, Washington 98109 

Attn: Wayne Bums, Senior Vice President Operations/Administration; 

with a copy to: 

Wilson Sonsini Goodrich & Rosati 

Suite 5100 

701 Fifth Avenue 

Seattle, Washington 98104 

Attn: Patrick Schultheis. 

  
 -11- 

 7. Effect of Amendment. Except as modified by this Fifth Amendment, the Lease and all the
covenants, agreements, terms, provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions and conditions contained in this Fifth Amendment shall bind and
inure to the benefit of the parties hereto and their respective successors and, except as otherwise provided in the Lease, their respective assigns. In the event of any conflict between the terms contained in this Fifth Amendment and the Lease, the
terms herein contained shall supersede and control the obligations and liabilities of the parties. From and after the date hereof, the term “Lease” as used in the Lease shall mean the Lease, as modified by this Fifth Amendment. 

8. Miscellaneous. This Fifth Amendment becomes effective only upon execution and delivery hereof by Landlord and Tenant. The captions
of the paragraphs and subparagraphs in this Fifth Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All exhibits hereto are incorporated herein by
reference. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease, lease amendment or otherwise until execution by and delivery to both
Landlord and Tenant. 
 9. Counterparts. This Fifth Amendment may be executed in one or more counterparts, each of which, when taken
together, shall constitute one and the same document. 
 [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
 -12- 

 IN WITNESS WHEREOF, Landlord and Tenant have hereunto set their hands as of the date and year
first above written, and acknowledge that they possess the requisite authority to enter into this transaction and to execute this Fifth Amendment. 

LANDLORD: 
 BMR-530 FAIRVIEW AVENUE LLC, 

a Delaware limited liability company 
  

			
		
	By:		/s/ Kevin M. Simonsen
		
	Name:		Kevin M. Simonsen
		
	Title:		VP, Real Estate Legal

 TENANT: 

NANOSTRING TECHNOLOGIES, INC., 
 a Delaware corporation 

 

			
		
	By:		/s/ Wayne D. Burns
		
	Name:		Wayne D. Burns
		
	Title:		Sr. VP, Operations & Administration

  
 -13- 

 SIXTH AMENDMENT TO LEASE 

THIS SIXTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this
11th day of September, 2014, by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware
corporation (“Tenant”). 
 RECITALS 

A. WHEREAS, Landlord and Tenant entered into that certain Lease dated as of October 19, 2007 (the “Original Lease”);

 B. WHEREAS, the Original Lease was amended by that certain First Amendment to Lease dated May 21, 2009 (“First
Amendment”), that certain Second Amendment to Lease dated June 16, 2010 (“Second Amendment”), that certain Third Amendment to Lease dated February 4, 2011 (“Third Amendment”), that certain Fourth
Amendment to Lease dated May 31, 2012 (“Fourth Amendment”), and that certain Fifth Amendment to Lease dated July 9, 2013 (“Fifth Amendment”; and together with the Original Lease, the First Amendment, the
Second Amendment, the Third Amendment, and the Fourth Amendment, as the same may have been previously amended, amended and restated, supplemented or otherwise modified from time to time, the “Lease”); 

C. WHEREAS, pursuant to the Lease, Tenant leases certain premises from Landlord in the building located at 530 Fairview Avenue North in
Seattle, Washington (the “Building”), which premises are more particularly described in the Lease (the “Premises”); 

D. WHEREAS, Landlord and Tenant acknowledge and agree that the Building and Premises may be remeasured, and the Rentable Area of each of them
is subject to adjustment in accordance therewith; 
 E. WHEREAS, BMR-500 Fairview Avenue LLC, a Delaware limited liability company (together
with its successors and assigns, “Adjacent Building Landlord”), an affiliate of Landlord, intends (but is not obligated) to construct a building (“Adjacent Building”) on the land adjacent to the Building, which
adjacent land is located at 500 Fairview Avenue North in Seattle, Washington (“Adjacent Property”); and 
 F. WHEREAS, in
connection with the planned construction of the Adjacent Building, Landlord and Tenant desire to, among other things, to clarify certain provisions regarding remeasurement of the Project (as defined below), Operating Expenses and the Project, and
surrender of certain portions of the Premises, all on the terms and conditions as more particularly set forth herein. 

  
 -14- 

 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions.
For purposes of this Amendment, capitalized terms shall have the meanings ascribed to them in the Lease unless otherwise defined herein. The Lease, as amended by this Amendment, is referred to herein as the “Amended Lease.” 

2. Effectiveness. Completion of the Adjacent Building, as reasonably determined by Landlord, is a condition precedent to the
effectiveness of Sections 3, 4, 5, and 6 of this Amendment, and such Sections of this Amendment are effective on the date that Landlord so determines that completion of the Adjacent Building occurs
(“Adjacent Building Completion Date”), and not until then. 
 3. Project Common Area. The defined term
“Project” under the Lease is hereby amended and restated to mean the Property, the Adjacent Property, and all landscaping, parking facilities, private drives and other improvements and appurtenances related thereto, including the
Building and, from and after the Adjacent Building Completion Date, the Adjacent Building. All portions of the Building that are from time to time designated by Landlord as being for the non-exclusive use of the tenants (or other occupants) of the
Building only, and not the tenants (or other occupants) of the Project generally, such as service corridors, stairways, elevators, public restrooms and public lobbies (all to the extent located in the Building), are hereinafter referred to as
“Building Common Area.” All portions of the Project that are from time to time designated by the owner or ground lessee of such portion of the Project as being for the non-exclusive use of tenants of the Project generally, including
driveways, sidewalks, parking areas, landscaped areas, service corridors, stairways, elevators, public restrooms and public lobbies (but excluding Building Common Area and areas from time to time designated by such owner or ground lessee as being
for the exclusive use of tenants (or other occupants) of such portion of the Project), are hereinafter referred to as “Project Common Area.” The defined term “Common Area” under the Lease is hereby amended and
restated so as to reference the Building Common Area and Project Common Area, collectively. 
 4. Pro Rata Share. 

(a) Tenant acknowledges that some or all of the Project, including the Building, may be remeasured in connection with the completion of
construction of the Adjacent Building. In connection with any such remeasurement, the table in Section 2.2 of the Lease will be deleted and replaced with an appropriate replacement table with appropriate numbers to be completed by
Landlord. Base Rent shall be neither increased nor decreased with respect to the Premises as a result of any remeasurement. 
 (b) Effective
on the Adjacent Building Completion Date, Section 9.2 of the Lease is hereby amended by adding the following language at the end of such Section: “The Rentable Area of each other building in the Project will be determined in a
similar manner.” 

  
 -15- 

 (c) Effective on the Adjacent Building Completion Date, the Lease is hereby amended by adding the
following language as new Section 9.7: 
 “9.7 The Rentable Area of the Project is the total Rentable Area of all buildings
within the Project.” 
 5. Operating Expenses. Section 8.1(a) of the Lease is hereby amended by replacing the second
and third instances of the word, “Building”, with the word “Project”, and by adding the following language after the final paragraph thereof: 

“Since the Project consists of multiple buildings, certain Operating Expenses may pertain to a particular building(s) and
other Operating Expenses to the Project as a whole. Landlord reserves the right in its sole discretion to allocate any such costs applicable to any particular building within the Project to such building, and other such costs applicable to the
Project to each building or certain buildings in the Project (which may include the Building), with the tenants in each building being responsible for paying their respective proportionate shares of such building costs to the extent required under
their leases. Landlord shall allocate such costs to such buildings (including the Building) in a reasonable, non-discriminatory manner, and such allocation shall be binding on Tenant.” 

6. Indemnity. Section 21.1 of the Lease is hereby replaced in its entirety with the following: 

“Tenant agrees to indemnify, defend and save Landlord and Adjacent Building Landlord harmless from and against any and all
demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses (including, without limitation, reasonable attorneys’ fees, charges and disbursements) incurred in investigating
or resisting the same (collectively, “Claims”) arising from injury or death to any person or damage to any property occurring within or about the Premises, the Building, the Property, or the Project arising directly or indirectly
out of Tenant’s or Tenant’s employees’, agents’ or guests’ use or occupancy of the Premises, the Building, the Property, or the Project or a breach or default by Tenant in the performance of any of its obligations hereunder
except to the extent caused by Landlord’s breach of Lease, willful misconduct or gross negligence. Subject to Section 21.2, Landlord agrees to indemnify, defend and save Tenant harmless from and against any and all Claims arising from
injury or death to any person or damage to any property occurring within or about the Premises, the Building or the Property to the extent that the same arise directly or indirectly out of the breach of Lease, willful misconduct or gross negligence
of Landlord or Landlord’s employees, agents or guests, except to the extent caused by Tenant’s breach of Lease, willful misconduct or negligence.” 

7. Work at the Project; Surrender of a Portion of the Premises. Tenant acknowledges and agrees that certain work may be performed at
the Project, at Landlord’s sole 

  
 -16- 

 
and absolute discretion, with respect to construction and development of the Adjacent Building and additional Common Areas. Such work may be noisy and disruptive, and may create dust. Further,
upon Landlord’s written notice thereof, that certain portion of the Premises which is more particularly depicted on Exhibit A hereto (“Surrendered Space”) shall be surrendered to Landlord and, at such time:
(a) the Amended Lease shall terminate with respect to the Surrendered Space only; (b) the Surrendered Space shall no longer be deemed to be within the Premises; (c) the Surrendered Space shall be deemed to be Common Area; and
(d) appropriate adjustments shall be made to the Amended Lease to reflect the foregoing, except that the Rentable Area of the Building, Premises and Project, Tenant’s Pro Rata Share of the Building and Project, and Additional Rent shall
not be adjusted until the remeasurement contemplated by Section 4(a) is completed; further, Base Rent shall neither increase nor decrease with respect to the Premises as a result of such surrender or any remeasurement. In connection with
all of the foregoing, Tenant hereby waives and releases Landlord from any and all claims or causes of action with respect to or otherwise arising from such work or the surrender of the Surrendered Space. Tenant acknowledges and agrees that no such
disruption, noise, or surrender will be deemed a breach of the Amended Lease by Landlord, nor shall it be deemed a nuisance or interference with Tenant’s right to quiet enjoyment of the Premises or rights to the Common Area. In furtherance of
the foregoing, in no event shall such work or surrender (x) cause Rent to abate under the Amended Lease (except as expressly set forth in this Section 7), (y) give rise to any claim by Tenant for damages or (z) constitute
a forcible or unlawful entry, a detainer or an eviction of Tenant. 
 8. Broker. Tenant represents and warrants that it has not dealt
with any broker or agent in the negotiation for or the obtaining of this Amendment and agrees to indemnify, defend and hold Landlord harmless from and against any and all costs or liabilities for compensation claimed by any such broker or agent
employed or engaged by Tenant or claiming to have been employed or engaged by Tenant. Landlord agrees to indemnify, defend and hold Tenant harmless from any and all costs or liabilities for compensation claimed by any broker or agent, employed or
engaged by Landlord or claiming to have been employed or engaged by Landlord. 
 9. No Default. Tenant represents, warrants and
covenants that, to the best of Tenant’s actual knowledge, Tenant is not in default of any of its respective obligations under the Lease and no event has occurred that, with the passage of time or the giving of notice (or both), would constitute
a default by Tenant thereunder. 
 10. Effect of Amendment. Except as modified by this Amendment, the Lease and all of the covenants,
agreements, terms, provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions and conditions contained in this Amendment shall bind and inure to the
benefit of the parties hereto and their respective successors and, except as otherwise provided in the Lease, their respective assigns. In the event of any conflict between the terms contained in this Amendment and the Lease, the terms herein
contained shall supersede and control the obligations and liabilities of the parties. From and after the date hereof, the term “Lease” as used in the Amended Lease shall mean the Amended Lease. Except as set forth in the immediately
preceding sentence, capitalized terms used in the Amended Lease that are defined herein will (effective as of the date hereof, or if the Amendment specifies a later date for the effectiveness of the provision that includes such definition, then as
of such later date), have the meanings specified herein, even if such terms are defined in the Lease to have different meanings. 

  
 -17- 

 11. Miscellaneous. No provision of this Amendment becomes effective before execution and
delivery hereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All
exhibits hereto are incorporated herein by reference. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease, lease amendment or
otherwise until execution by and delivery to both Landlord and Tenant. 
 12. Counterparts. This Amendment may be executed in one or
more counterparts, each of which, when taken together, shall constitute one and the same document. 
 [REMAINDER OF THIS PAGE INTENTIONALLY
LEFT BLANK] 

  
 -18- 

 IN WITNESS WHEREOF, Landlord and Tenant have hereunto set their hands as of the date and year
first above written, and acknowledge that they possess the requisite authority to enter into this transaction and to execute this Amendment. 

LANDLORD: 
 BMR-530 FAIRVIEW AVENUE
LLC, 
 a Delaware limited liability company 
  

			
		
	By:		/s/ Kevin M. Simonsen
		
	Name:		Kevin M. Simonsen
		
	Title:		VP, Real Estate Legal

 State of California) 
 County of
San Diego) 
 On
                                 before me,
                                , personally appeared
                                , who proved to me on the basis of satisfactory
evidence to be the person(s) whose name(s)is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the
person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 
 I certify under PENALTY OF PERJURY under the laws of the
State of California that the foregoing paragraph is true and correct. 
 WITNESS my hand and official seal. 

Signature
                                         
        (Seal) 

  
 -19- 

 TENANT: 

NANOSTRING TECHNOLOGIES, INC., 
 a Delaware corporation 

 

			
		
	By:		/s/ Wayne Burns
		
	Name:		 
		
	Title:		 

 State of WA) 
 County of King)

 On 10 September 2014 before me, Wayne Burns , personally appeared before me, who proved to me on the basis of satisfactory
evidence to be the person(s) whose name(s)is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the
person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 
 I certify under PENALTY OF PERJURY under the laws of the
State of California that the foregoing paragraph is true and correct. 
 WITNESS my hand and official seal. 

Signature /s/ Susan R. Van Den Ameele (Seal) 
  

 

  
 -20- 

 EXHIBIT A 

SURRENDERED SPACE 

  
 -21- 

	
	 

  
 -22- 

  

	
	

  
 -23- 

							
	 State of California
				)		California All-Purpose
Certificate of Acknowledgement
	 County of San Diego
		 ____________________________
		)	

 On September 12, 2014 before me, Kristen M. White, Notary
Public,                                        
                                 

(here insert name and title of the officer) 

personally appeared Kevin Simonsen, Vice President, Real Estate
Counsel                                        
                     

                          
                                         
                                         
                                         
                               , 

who proved to me on the basis of satisfactory evidence to be the person whose name is subscribed to the within instrument and acknowledged to me that he
executed the same in his authorized capacity, and that by his signature on the instrument of the person, or the entity upon behalf of which the person acted, executed the instrument. 

 

			
	I certify under PENALTY OF PERJURY under the laws of the State of California that the foregoing paragraph is true and correct.		

 WITNESS my hand and official seal. 

Signature /s/ Kristen M.
White                                        
                                         
        (Seal) 
  

					
	 		OPTIONAL INFORMATION		 
				

 Although the information in this section is not required by law, It could prevent fraudulent removal and reattachment of
this acknowledgment to an unauthorized document and may prove useful to persons relying on the attached document. 
  
 

 

  
 -24- 

 SEVENTH AMENDMENT TO LEASE 

THIS SEVENTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this
22nd day of December, 2014 (“Execution Date”), by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING
TECHNOLOGIES, INC., a Delaware corporation (“Tenant”). 
 RECITALS 

A. WHEREAS, Landlord and Tenant entered into that certain Lease dated as of October 19, 2007 (the “Original Lease”);

 B. WHEREAS, the Original Lease was amended by that certain First Amendment to Lease dated May 21, 2009 (“First
Amendment”), that certain Second Amendment to Lease dated June 16, 2010 (“Second Amendment”), that certain Third Amendment to Lease dated February 4, 2011 (“Third Amendment”), that certain Fourth
Amendment to Lease dated May 31, 2012 (“Fourth Amendment”), that certain Fifth Amendment to Lease dated July 9, 2013 (“Fifth Amendment”; and that certain Sixth Amendment to Lease dated September 11,
2014 (“Sixth Amendment”). As used herein, the “Existing Lease” shall mean the Original Lease as amended by the First Amendment, the Second Amendment, the Third Amendment, the Fourth Amendment, the Fifth Amendment,
and the Sixth Amendment; 
 C. WHEREAS, pursuant to the Existing Lease, Tenant leases certain premises from Landlord in the building located
at 530 Fairview Avenue North in Seattle, Washington (the “Building”), which premises are more particularly described in Exhibit A attached hereto (the “Premises”); 

D. WHEREAS, Landlord and Tenant desire to extend the Term of the Existing Lease to be coterminous with that certain Lease dated of even date
herewith (the “Adjacent Building Lease”) between Landlord’s affiliate, BMR-500 Fairview Avenue LLC, a Delaware limited liability company, and Tenant for certain premises located in the Adjacent Building (as defined in Recital E
of the Sixth Amendment) (the “Adjacent Building Premises”), and otherwise amend the Existing Lease as set forth herein; and 

E. WHEREAS, Landlord and Tenant desire to modify and amend the Existing Lease only in the respects and on the conditions hereinafter stated.

 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the Recitals set forth above which are incorporated herein by this reference, and in
consideration of mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 

  
 -25- 

 1. Definitions. For purposes of this Amendment, capitalized terms shall have the meanings
ascribed to them in the Existing Lease unless otherwise defined herein. The Existing Lease, as amended by this Amendment, is referred to collectively herein as the “Lease.” 

2. Extension of Term. Effective as of the Execution Date, the Term of the Lease is hereby extended by the period (the “Extended
Term”) commencing upon the first day of the first full month after the full execution and delivery of this Amendment and the Adjacent Building Lease (the “Extended Term Commencement Date”) and expiring on the date that is
the “Term Expiration Date” under the Adjacent Building Lease (the “Extended Term Expiration Date”). Tenant shall execute and deliver to Landlord written acknowledgment of the actual Extended Term Commencement Date and the
Extended Term Expiration Date within ten (10) business days after the Adjacent Building Lease Term Commencement Date (as hereinafter defined), in the form attached as Exhibit B hereto. From and after the Execution Date, all
references in the Lease to the “Term” shall mean and refer to the Term, as extended by the Extended Term, and all references in the Lease to the “Term Expiration Date” shall mean and refer to the Extended Term Expiration Date.
The “Adjacent Building Lease Term Commencement Date” shall be the date that is the “Term Commencement Date” under the Adjacent Building Lease. 

3. Rentable Areas and Tenant’s Pro Rata Shares. Effective as of the Execution Date, the Rentable Area of the Premises and the
Building and Tenant’s Pro Rata Share of the Building, for all purposes under the Lease, are as follows: 
  

					
	 Definition or Provision
	  	Means the Following (as of the
Execution Date)	 
	 Approximate Rentable Area of Premises
	  	 	36,268	  
	 Approximate Rentable Area of Building
	  	 	96,188	  
	 Tenant’s Pro Rata Share of Building
	  	 	37.71	% 

 Effective upon the Adjacent Building Completion Date (as defined in Section 2 of the Sixth Amendment), the
Rentable Area of the Project and Tenant’s Pro Rata Share of the Project, for all purposes under the Lease, shall be as follows: 
  

					
	 Definition or Provision
	  	Means the Following (as of the
Adjacent Building Completion Date)	 
	 Approximate Rentable Area of Project
	  	 	223,820	  
	 Tenant’s Pro Rata Share of Project
	  	 	16.20	% 

  
 -26- 

 4. Basic Annual Rent. Effective as of the Extended Term Commencement Date, the initial
Basic Annual Rent for the Premises during the Extended Term shall be as follows, subject to adjustment as set forth in Section 5 below: 
  

																	
	 Dates of Extended Term
	  	Square Feet
of Rentable
Area	 	  	Basic Annual Rent
per Square Foot of
Rentable Area	 	  	Basic Monthly
Rent	 	  	Basic Annual
Rent	 
	 Months 1 — 12
	  	 	36,268	  	  	$	49.75 annually	  	  	$	150,361.08	  	  	$	1,804,333.00	  

 5. Rent Adjustments. Basic Annual Rent shall be subject to an annual upward adjustment of three percent
(3%) of the then-current Basic Annual Rent. The first such adjustment shall become effective commencing on the first (1st) annual anniversary of the Extended Term Commencement Date, and
subsequent adjustments shall become effective on every successive annual anniversary during the Extended Term. 
 6. Extension Tenant
Improvements and Extension TI Allowance. 
 6.1 Landlord shall make available to Tenant a tenant improvement allowance in an amount not
to exceed One Million Eighty-Eight Thousand Forty and No/100 Dollars ($1,088,040.00) (based upon Thirty and No/100 Dollars ($30.00) per square foot of Rentable Area of the Premises) (the “Extension TI Allowance”) to fund appropriate
improvements to the Premises consistent with the Permitted Use (the “Extension Tenant Improvements”) in accordance with the work letter attached as Exhibit C hereto (the “Extension Work Letter”). Tenant
shall cause the Extension Tenant Improvements to be constructed in the Premises pursuant to the Extension Work Letter at a cost to Landlord not to exceed the Extension TI Allowance. The Extension TI Allowance may be applied to the costs of
(a) construction, (b) project review by Landlord (which fee shall equal two percent (2%) of the cost of the Extension Tenant Improvements, including the Extension TI Allowance, but shall not exceed Twenty Thousand and No/100 Dollars
($20,000.00)), (c) commissioning of mechanical, electrical and plumbing systems by a licensed, qualified commissioning agent hired by Tenant, and review of such party’s commissioning report by a licensed, qualified commissioning agent
hired by Landlord, (d) space planning, architect, engineering and other related services performed by third parties unaffiliated with Tenant, (e) building permits and other taxes, fees, charges and levies by Governmental Authorities for
permits or for inspections of the Extension Tenant Improvements, and (f) costs and expenses for labor, material, equipment and fixtures. In no event shall the Extension TI Allowance be used for (g) the cost of work that is not authorized
by the Approved Plans (as defined in the Extension Work Letter) or otherwise approved in writing by Landlord, which approval shall not be unreasonably withheld, conditioned or delayed, (h) payments to Tenant or any affiliates of Tenant,
(i) the purchase of any furniture, personal property or other non-building system equipment, (j) costs resulting from any default by Tenant of its obligations under the Lease or (k) costs that are recovered by Tenant from a third
party (e.g., insurers, warrantors, or tortfeasors). Notwithstanding anything to the contrary in the Lease (including but not limited to Section 18.11 in the Original Lease), Landlord shall not

  
 -27- 

 
charge Tenant any plan or construction review, oversight, supervision or management fees in relation to the Extension Tenant Improvements other than the amount set forth in
Section 6.1(b) above. In addition to the Extension TI Allowance, Landlord shall contribute up to Five Thousand Four Hundred Forty and 20/100 Dollars ($5,440.20) (based upon 15/100 Dollars ($0.15) per square foot of Rentable Area of the
Premises) to pay the cost of developing a test fit plan for the Premises (the “Extension Test Fit Allowance”), which shall be disbursed by Landlord in accordance with the Extension Work Letter. 

6.2 Tenant shall have until the date that is two (2) years after the Extended Term Commencement Date (the “Extension TI
Deadline”), to expend the unused portion of the Extension Test Fit Allowance and Extension TI Allowance, after which date Landlord’s obligation to fund such costs shall expire. Notwithstanding the foregoing, if the cost of the tenant
improvements to be performed by Tenant in the Adjacent Building Premises in accordance with the Adjacent Building Lease (the “500 Tenant Improvements”) exceeds the amount of the tenant improvement allowance available for the 500
Tenant Improvements pursuant to the Adjacent Building Lease, then Tenant shall have the right (the “TI Allowance Reallocation Right”) to reallocate a portion of any unused Extension TI Allowance (the “Reallocated TI
Allowance Amount”) to pay such excess cost of constructing the 500 Tenant Improvements (subject to the limitations set forth in the Adjacent Building Lease), on the terms and conditions set forth in the TI Allowance Reallocation Agreement
attached as Exhibit D hereto (the “TI Reallocation Agreement”). Upon Tenant’s exercise of the TI Allowance Reallocation Right, the Extension TI Allowance shall be permanently reduced by the Reallocated TI Allowance
Amount, and Landlord shall have no further obligation to fund the Reallocated TI Allowance Amount. 
 6.3 Tenant shall be solely responsible
for any costs related to the Extension Tenant Improvements in excess of the Extension TI Allowance (the “Excess Costs”). In no event shall any unused Extension TI Allowance entitle Tenant to a credit against Rent payable under this
Lease. If the amount of the Approved Budget is greater than the Extension TI Allowance (plus any amount of the tenant improvement allowance from the Adjacent Building Lease that is allocated to the costs of the Extension Tenant Improvements pursuant
to the TI Reallocation Agreement), but less than or equal to one hundred ten percent (110%) of the Extension TI Allowance, then Landlord shall first pay the entire Extension TI Allowance, and after the entire Extension TI Allowance (plus any
amount of the tenant improvement allowance from the Adjacent Building Lease that is allocated to the costs of the Extension Tenant Improvements pursuant to the TI Reallocation Agreement) has been expended, Tenant shall pay the Excess Costs. If the
amount of the Approved Budget (as defined in Exhibit C) exceeds one hundred ten percent (110%) of the Extension TI Allowance (plus any amount of the tenant improvement allowance from the Adjacent Building Lease that is allocated to
the costs of the Extension Tenant Improvements), then Tenant shall deposit an amount equal to the Excess Costs with Landlord no less than ten (10) Business Days before commencing work on the Extension Tenant Improvements. In such case
Tenant’s funds shall be disbursed by Landlord on a pari pasu basis with the Extension TI Allowance as set forth in the attached Exhibit C. Following disbursement of the Extension TI Allowance and any Tenant funds deposited with
Landlord, Tenant shall pay for all remaining Costs of the Work, within ten (10) Business Days after written notice from Landlord of the amount due from Tenant. At the option of Landlord, amounts payable by Tenant pursuant to this paragraph
shall be paid directly to Contractor or such other party as Landlord may reasonably designate in writing. 

  
 -28- 

 6.4 Prior to commencing the Extension Tenant Improvements, Tenant shall furnish to Landlord
evidence satisfactory to Landlord that insurance coverages required of Tenant under the provisions of Exhibit C-1 are in effect. 

6.5 Landlord and Tenant shall mutually agree upon the selection of the architect, engineer, general contractor and major subcontractors, and
Landlord and Tenant shall each participate in the review of the competitive bid process. Landlord shall not unreasonably withhold consent, but may refuse to use any architects, consultants, contractors, subcontractors or material suppliers that
Landlord reasonably believes could cause labor disharmony. 
 7. Operating Expenses. 

7.1 During the Extended Term, Tenant shall continue to be responsible for Tenant’s Share of Operating Expenses in accordance with the
Lease. In the event that the Building or Project is less than fully occupied during a calendar year, Tenant acknowledges that Landlord may extrapolate Operating Expenses that vary depending on the occupancy of the Building or Project, as applicable,
to equal Landlord’s reasonable estimate of what such Operating Expenses would have been had the Building or Project, as applicable, been ninety-five percent (95%) occupied during such calendar year; provided, however, that Landlord shall
not recover more than one hundred percent (100%) of Operating Expenses. 
 7.2 The paragraph added under Section 5 of the
Sixth Amendment is revised as follows (new language underlined; deleted language crossed out): 
 Since the Project consists of multiple
buildings, certain Operating Expenses may pertain to a particular building(s) and other Operating Expenses to the Project as a whole. Landlord reserves the right in its sole reasonable discretion to allocate any such costs applicable to any
particular building within the Project to such building, and other such costs applicable to the Project to each building or certain buildings in the Project (which may include the Building), with the tenants in each building being responsible for
paying their respective proportionate shares of such building costs to the extent required under their leases. If Landlord allocates certain costs to other building(s) in the Project, said costs shall not be included in the Operating Expenses for
the Project as a whole; if Landlord allocates certain Operating Expenses to the Building only, Tenant shall only be responsible for that amount of Operating Expenses equal to Tenant’s Pro Rata Share of the Building. Landlord shall allocate such
costs to such buildings (including the Building) in a reasonable, non-discriminatory manner, and such allocation shall be binding on Tenant. 

8. Hours of Operation; Tenant’s Access. The Project’s hours of operation are currently 7:00 am to 6:00 pm Monday through
Friday. Tenant shall have access to the Premises twenty-four (24) hours a day, seven (7) days a week, every day of the year. 

  
 -29- 

 9. Renewal Options. Section 42 of the Original Lease is hereby deleted in its
entirety. Effective as of the Execution Date, Tenant shall have two (2) options (each, an “Option”) to further extend the Term by five (5) years each as to the entire Premises (and no less than the entire Premises) upon the
following terms and conditions. Any extension of the Term pursuant to an Option shall be on all the same terms and conditions as the Lease, except as follows: 

9.1 Basic Annual Rent at the commencement of each Option term shall equal the then-current fair market value for comparable office and
laboratory space in the Seattle market of comparable age, quality, level of finish and proximity to amenities and public transit including market rate annual adjustments (“FMV”), but in no event be less than the Basic Annual Rent in
effect immediately prior to the Option term for the first year of the Option term. Tenant may, no more than twelve (12) months prior to the date the Term is then scheduled to expire, request Landlord’s estimate of the FMV for the next
Option term. Landlord shall, within fifteen (15) days after receipt of such request, give Tenant a written proposal of such FMV. If Tenant gives written notice to exercise an Option, such notice shall specify whether Tenant accepts
Landlord’s proposed estimate of FMV. If Tenant does not accept the FMV, then the parties shall endeavor to agree upon the FMV, taking into account all relevant factors, including (v) the size of the Premises, (w) the length of the
Option term, (x) rent in comparable buildings in the relevant market, including concessions offered to new tenants, such as free rent, tenant improvement allowances, leasing commissions, and moving allowances, (y) Tenant’s
creditworthiness and (z) the quality and location of the Building and the Project. In the event that the parties are unable to agree upon the FMV within thirty (30) days after Tenant notifies Landlord that Tenant is exercising an Option,
then either party may request that the same be determined as follows: a senior officer of a nationally recognized leasing brokerage firm with local knowledge of the Seattle laboratory/research and development leasing market (the “Baseball
Arbitrator”) shall be selected and paid for jointly by Landlord and Tenant. If Landlord and Tenant are unable to agree upon the Baseball Arbitrator, then the same shall be designated by the local chapter of the Judicial Arbitration and
Mediation Services or any successor organization thereto (the “JAMS”). The Baseball Arbitrator selected by the parties or designated by JAMS shall (i) have at least ten (10) years’ experience in the leasing of
laboratory/research and development space in the Seattle market and (ii) not have been employed or retained by either Landlord or Tenant or any affiliate of either for a period of at least ten (10) years prior to appointment pursuant
hereto. Each of Landlord and Tenant shall submit to the Baseball Arbitrator and to the other party its determination of the FMV. The Baseball Arbitrator shall grant to Landlord and Tenant a hearing and the right to submit evidence. The Baseball
Arbitrator shall determine which of the two (2) FMV determinations more closely represents the actual FMV. The Baseball Arbitrator may not select any other FMV for the Premises other than one submitted by Landlord or Tenant. The FMV selected by
the Baseball Arbitrator shall be binding upon Landlord and Tenant and shall serve as the basis for determination of Basic Annual Rent payable for the applicable Option term. If, as of the commencement date of an Option term, the amount of Basic
Annual Rent payable during the Option term shall not have been determined, then, pending such determination, Tenant shall pay Basic Annual Rent equal to the Basic Annual Rent payable with respect to the last year of the then-current Term. After the
final determination of Basic Annual Rent payable for the Option term, the parties shall promptly execute a written amendment to the Lease specifying the amount of Basic Annual Rent to be paid during the applicable Option term. Any failure of the
parties to execute such amendment shall not affect the validity of the FMV determined pursuant to this Section. 

  
 -30- 

 9.2 The Option is not assignable separate and apart from the Lease except that it shall be
exercisable by a Tenant’s Affiliate as a result of a Transfer of this Lease to a Tenant’s Affiliate in accordance herewith. 
 9.3
An Option is conditional upon Tenant giving Landlord written notice of its election to exercise such Option not more than sixteen (16) months and not less than ten (10) months prior to the end of the expiration of the then-current Term.
Time shall be of the essence as to Tenant’s exercise of an Option. Tenant assumes full responsibility for maintaining a record of the deadlines to exercise an Option. Tenant acknowledges that it would be inequitable to require Landlord to
accept any exercise of an Option after the date provided for in this Section. 
 9.4 Notwithstanding anything contained in this Article to
the contrary, Tenant shall not have the right to exercise an Option: 
 (a) During the time commencing from the date Landlord delivers to
Tenant a written notice that Tenant is actually in default under any provisions of the Lease and continuing until Tenant has cured the specified default to Landlord’s reasonable satisfaction; or 

(b) Intentionally deleted; or 

(c) In the event that Tenant has defaulted (beyond applicable notice and cure periods) in the performance of either a material monetary
obligation or material non-monetary obligations under the Lease two (2) or more times during the Extended Term or Option Term (as applicable). 

9.5 The period of time within which Tenant may exercise an Option shall not be extended or enlarged by reason of Tenant’s inability to
exercise such Option because of the provisions of Section 9.4 above. 
 9.6 All of Tenant’s rights under the provisions of
an Option shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of such Option if, after such exercise, but prior to the commencement date of the new term, (a) Tenant fails to pay to Landlord a
material monetary obligation of Tenant for a period of twenty (20) days after written notice from Landlord to Tenant, (b) Tenant fails to commence to cure a material non-monetary default (other than a material monetary default) within
thirty (30) days after the date Landlord gives written notice to Tenant of such default or (c) Tenant has defaulted (beyond applicable notice and cure periods) with respect to either a material monetary obligation or its material
non-monetary obligations under the Lease two (2) or more times during the Extended Term or Option Term (as applicable). 
 10.
Parking. At Tenant’s sole option, Tenant shall continue to be entitled to rent from Landlord on a monthly basis from time to time throughout the Term an amount of parking spaces not to exceed Tenant’s Parking Space Allowance on an
unreserved basis, provided that, as of the 

  
 -31- 

 
Execution Date, the rate for such parking spaces shall be One Hundred Ninety Dollars ($190.00) per parking space per month, which rate shall be subject to annual market-based increases not
greater than three percent (3%) per calendar year. 
 11. Right of First Offer. The parties hereto acknowledge that
Tenant’s Right of First Offer set forth in Section 14 of the Third Amendment remains available and in full force and effective throughout the Extended Term and any further extension of the same. 

12. Permitted Use. Section 2.9 of the Original Lease shall be amended to add light manufacturing in compliance with
Applicable Laws to the Permitted Use. 
 13. Condition of Premises. Subject to Landlord’s representations, warranties and
obligations under the Lease, Tenant acknowledges that (a) it is in possession of and is fully familiar with the condition of the Premises and agrees to take the same in its condition “as is” as of the Extended Term Commencement Date,
and (b) Landlord shall have no obligation to alter, repair or otherwise prepare the Premises for Tenant’s continued occupancy for the Extended Term or to pay for any improvements to the Premises, except for Landlord’s obligation to
disburse the Extension TI Allowance and the Extension Test Fit Allowance in accordance with this Amendment. 
 14. Financials.
Notwithstanding anything to the contrary in the Lease, so long as Tenant is a publicly traded company that periodically publishes its financial statements, Tenant shall not be required to provide additional statements to Landlord. 

15. Insurance. The last sentence of Section 22.3 of the Original Lease is amended to read as follows: 

Tenant, at Tenant’s sole cost and expense, carry Commercial Property insurance covering property damage to the full replacement cost
value. Covered property shall not include permanent improvements in the Premises installed by Tenant or furnished by Landlord which shall be insured by Landlord pursuant to Section 22.1, but shall include Tenant’s Property including
personal property, furniture, fixtures, machinery, equipment, stock, inventory and improvements and betterments, which may be owned by Tenant and required to be insured hereunder, or which may be leased, rented, borrowed or in the care custody or
control of Tenant, or Tenant’s agents, employees or subcontractors. Such insurance, with respect only to all Tenant Improvements, Alterations or other work performed on the Premises by Tenant (collectively, “Tenant Work”),
shall name Landlord and Landlord’s current and future mortgagees as loss payees as their interests may appear. Such insurance shall be written on an “all risk” of physical loss or damage basis including the perils of fire, extended
coverage, electrical injury, mechanical breakdown, windstorm, vandalism, malicious mischief, sprinkler leakage, back-up of sewers or drains, earthquake, terrorism and such other additional risks Landlord may from time to time designate that are
generally required by landlords of similar properties in accordance with prudent business practices, for the full replacement cost value of the covered items with an agreed amount endorsement with no co-insurance. 

  
 -32- 

 16. Brokers. Each party represents and warrants to the other that it has had no dealings
with any real estate broker or agent in connection with the negotiation of this Amendment other than Flinn Ferguson and CBRE (“Brokers”). Each party agrees to reimburse, indemnify, save, defend (at the other party’s option and
with counsel reasonably acceptable to the other party, at its sole cost and expense) and hold harmless the other party and its affiliates and their respective shareholders, members, partners, directors, officers and employees and their respective
successors and assigns (the “Indemnitees”) for, from and against any and all cost or liability for compensation claimed by any such broker or agent, other than Brokers, employed or engaged by it or claiming to have been employed or
engaged by it. Brokers are entitled to leasing commissions in connection with the making of this Amendment, and Landlord shall pay such commissions to Brokers pursuant to separate agreements between Landlord and each Broker. 

17. No Default. Tenant represents and warrants that, to the best of Tenant’s knowledge, neither Landlord nor Tenant is in default
of any of their respective obligations under the Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by either Landlord or Tenant thereunder. Landlord represents and warrants
that, to the best of Landlord’s knowledge, neither Landlord nor Tenant is in default of any of their respective obligations under the Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would
constitute a default by either Landlord or Tenant thereunder. 
 18. Notices. Tenant confirms that, notwithstanding anything in the
Lease to the contrary, notices delivered to Tenant pursuant to the Lease should be sent to: 
 Nanostring Technologies, Inc., 

530 Fairview Avenue, Suite 2000 

Seattle, WA 98109 
 Attn: Wayne
Burns, Senior Vice President Operations/Administration 
 with a copy to: 

Nanostring Technologies, Inc., 

530 Fairview Avenue, Suite 2000 

Seattle, WA 98109 
 Attn: General
Counsel 
 19. Effect of Amendment. Except as modified by this Amendment, the Existing Lease and all the covenants, agreements,
terms, provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. In the event of any conflict between the terms contained in this Amendment and the Existing Lease, the terms herein contained shall
supersede and control the obligations and liabilities of the parties. From and after the date hereof, the term “Lease” as used in the Lease shall mean the Existing Lease, as modified by this Amendment. 

  
 -33- 

 20. Successors and Assigns. Each of the covenants, conditions and agreements contained in
this Amendment shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs, legatees, devisees, executors, administrators and permitted successors and assigns and sublessees. Nothing in this
section shall in any way alter the provisions of the Lease restricting assignment or subletting. 
 21. Miscellaneous. This Amendment
becomes effective only upon execution and delivery hereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in
construing the provisions hereof. All exhibits hereto are incorporated herein by reference. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective
as a lease, lease amendment or otherwise until execution by and delivery to both Landlord and Tenant. 
 22. Authority. Landlord and
Tenant each guarantee, warrant and represent to the other that the individual or individuals signing this Amendment have the power, authority and legal capacity to sign this Amendment on behalf of and to bind all entities, corporations,
partnerships, limited liability companies, joint venturers or other organizations and entities on whose behalf such individual or individuals have signed. Each party further guarantees, warrants and represents to the other that no third-party
consent or approval is required in connection with this Amendment, or if such consent or approval is required, it has been obtained. 
 23.
Counterparts; Facsimile and PDF Signatures. This Amendment may be executed in one or more counterparts, each of which, when taken together, shall constitute one and the same document. A facsimile or portable document format (PDF) signature on
this Amendment shall be equivalent to, and have the same force and effect as, an original signature 
 [REMAINDER OF THIS PAGE INTENTIONALLY
LEFT BLANK] 

  
 -34- 

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as of the date and year
first above written. 
 LANDLORD: 
 BMR-530
FAIRVIEW AVENUE LLC, 
 a Delaware limited liability company 
  

			
		
	By:		/s/ Kevin Simonsen
		
	Name:		Kevin M. Simonsen
		
	Title:		VP, Real Estate Legal

  

			
	STATE OF CALIFORNIA		}
			ss.
	COUNTY OF SAN DIEGO		

 On 12/19 , 2014, before me, Fern M
Kissel                                        
                                         
                , a Notary Public in and for said County and State, personally appeared Kevin M Simonsen, Vice President, Real Estate
Legal                                        
                                     , 

 

			
	 who proved to me on the basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and
acknowledged to me that he/she/they executed the same in his/her/their authorized capacit(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the
instrument.
  
 I certify under PENALTY OF PERJURY under the laws of the State of
California that the foregoing paragraph is true and correct.
		FOR NOTARY SEAL OR STAMP

 WITNESS my hand and official seal. 

Signature /s/ Fern M
Kissel                                        
     
  

  
 -35- 

 TENANT: 

NANOSTRING TECHNOLOGIES, INC., 
 a Delaware corporation 

 

			
		
	By:		/s/ Wayne D. Burns
		
	Name:		Wayne D. Burns
		
	Title:		Sr. VP, Operations & Administration

  

			
	STATE OF WASHINGTON		)
			)  ss.
	COUNTY OF KING		)

 On this 22nd day of December, 2014, before
me, the undersigned, a Notary Public in and for the State of Washington, duly commissioned and sworn personally appeared WAYNE
BURNS                                        
 , known to me to be the SVP Operations                         of NANOSTRING TECHNOLOGIES, INC., the corporation, that executed the foregoing instrument, and acknowledged the said instrument to be the free and voluntary act and deed of said corporation, for the purposes therein mentioned, and on oath stated that
he/she was authorized to execute said instrument. 
 I certify that I know or have satisfactory evidence that the person appearing before me
and making this acknowledgment is the person whose true signature appears on this document. 
 WITNESS my hand and official seal hereto
affixed the day and year in the certificate above written. 
  

	
	
	/s/ Julia Chandler
	Signature
	
	 Julia Chandler

	Print Name
	 NOTARY PUBLIC in and for the State of

Washington, residing at Seattle .
 My commission
expires 9-12-18 .

  
 -36- 

 EXHIBIT A 

PREMISES 
 LOTS 1, 2 AND 3 IN BLOCK
5 OF SORENSON’S ADDITION TO THE CITY OF SEATTLE, AS PER PLAT RECORDED IN VOLUME 1 OF PLATS, PAGE 218, RECORDS OF KING COUNTY; 
 EXCEPT THE EAST 2 FEET
THEREOF CONVEYED TO THE CITY OF SEATTLE BY DEED RECORDED UNDER RECORDING NO. 20000928001403; 
 SITUATE IN THE CITY OF SEATTLE, COUNTY OF KING, STATE OF
WASHINGTON. 

  
 -37- 

 EXHIBIT B 

ACKNOWLEDGEMENT OF EXTENDED TERM COMMENCEMENT DATE 

AND EXTENDED TERM EXPIRATION DATE 

THIS ACKNOWLEDGEMENT OF EXTENDED TERM COMMENCEMENT DATE AND EXTENDED TERM EXPIRATION DATE is entered into as of
[                ], 20[__], with reference to that certain Seventh Amendment to Lease (the “Amendment”) dated as of
December [    ], 20[__], by NANOSTRING TECHNOLOGIES, INC., a Delaware corporation (“Tenant”), in favor of BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company
(“Landlord”). All capitalized terms used herein without definition shall have the meanings ascribed to them in the Lease dated as of October 19, 2007 (as amended, including by this Amendment, the “Lease”)
between Landlord and Tenant for the premises located at 530 Fairview Avenue North in Seattle, Washington, as depicted in Exhibit A to the Amendment (the “Premises”). 

Tenant hereby confirms the following: 
 1. In
accordance with the provisions of Section 2 of the Amendment, the Extended Term Commencement Date is [                ], 20[__], and, unless the Lease
is terminated prior to the Extended Term Expiration Date pursuant to its terms, the Extended Term Expiration Date shall be [                ], 20[__]. 

2. The Lease is in full force and effect, and the same represents the entire agreement between Landlord and Tenant concerning the Premises[, except
[                                ]]. 

3. To the best of Tenant’s knowledge, Tenant has no existing defenses against the enforcement of the Lease by Landlord, and there exist no offsets or
credits against Rent owed or to be owed by Tenant. 
 4. The obligation to pay Rent is presently in effect, with Basic Annual Rent payable on the dates and
amounts set forth in the chart below: 
  

																	
	 Dates of Extended Term
	  	Square Feet of
Rentable Area	 	  	Basic Annual Rent
per Square Foot of
Rentable Area	 	  	Basic Monthly
Rent	 	  	Basic Annual
Rent	 
	 Months 1 - 12
	  	 	36,268	  	  	$	49.75 annually	  	  	$	150,361.08	  	  	$	1,804,333.00	  

 5. The undersigned Tenant has not made any prior assignment, transfer, hypothecation or pledge of the Lease or of the rents
thereunder or sublease of the Premises or any portion thereof. 
 [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
 -38- 

 IN WITNESS WHEREOF, Tenant has executed this Acknowledgment of Extended Term Commencement Date
and Extended Term Expiration Date as of the date first written above. 
 TENANT: 
  

			
	 NANOSTRING TECHNOLOGIES, INC.,
 a
Delaware corporation

		
	By:		 
		
	Name:		 
		
	Title:		 

  
 -39- 

 EXHIBIT C 

EXTENSION WORK LETTER 

This Extension Work Letter (this “Extension Work Letter”) is made and entered into as of the 22nd day of December, 2014, by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation
(“Tenant”), and is attached to and made a part of that certain Seventh Amendment to Lease dated of even date herewith (the “Amendment”), amending that certain Lease dated as of October 19, 2007 (as the same may
have been or may be amended, amended and restated, supplemented or otherwise modified from time to time, including by the Amendment, the “Lease”), by and between Landlord and Tenant for the Premises located at 530 Fairview Avenue
North in Seattle, Washington. All capitalized terms used but not otherwise defined herein shall have the meanings given them in the Lease. 
 1. General
Requirements. 
 1.1 Authorized Representatives. 

(a) Landlord designates, as Landlord’s authorized representative (“Landlord’s Authorized Representative”),
(i) John Moshy as the person authorized to initial plans, drawings, approvals and to sign change orders pursuant to this Extension Work Letter and (ii) an officer of Landlord as the person authorized to sign any amendments to this
Extension Work Letter or the Lease. Tenant shall not be obligated to respond to or act upon any such item until such item has been initialed or signed (as applicable) by the appropriate Landlord’s Authorized Representative. Landlord may change
either Landlord’s Authorized Representative upon one (1) business day’s prior written notice to Tenant. 
 (b) Tenant
designates Wayne Burns (“Tenant’s Authorized Representative”) as the person authorized to initial and sign all plans, drawings, change orders and approvals pursuant to this Extension Work Letter. Landlord shall not be obligated
to respond to or act upon any such item until such item has been initialed or signed (as applicable) by Tenant’s Authorized Representative. Tenant may change Tenant’s Authorized Representative upon one (1) business day’s prior
written notice to Landlord. 
 1.2 Schedule. The schedule for design and development of the Extension Tenant Improvements, including
the time periods for preparation and review of construction documents, approvals and performance, shall be in accordance with a schedule to be prepared by Tenant (the “Schedule”). Tenant shall prepare the Schedule so that it is
a reasonable schedule for the completion of the Extension Tenant Improvements. As soon as the Schedule is completed, Tenant shall deliver the same to Landlord for Landlord’s approval, which approval shall not be unreasonably withheld,
conditioned or delayed. Such Schedule shall be approved or disapproved by Landlord within ten (10) business days after delivery to Landlord. Landlord’s failure to respond within such ten (10) business day period shall be deemed
approval by Landlord. If Landlord disapproves the Schedule, 

  
 -40- 

 
then Landlord shall notify Tenant in writing of its objections to such Schedule, and the parties shall confer and negotiate in good faith to reach agreement on the Schedule. The
Schedule shall be subject to adjustment as mutually agreed upon in writing by the parties, or as provided in this Extension Work Letter. 

1.3 Tenant’s Architects, Contractors and Consultants. The architect, engineering consultants, design team, general contractor,
general contractor team and subcontractors responsible for the construction of the Extension Tenant Improvements shall be selected by Tenant and approved by Landlord, which approval Landlord shall not unreasonably withhold, condition or delay.
Landlord may refuse to use any architects, consultants, contractors, subcontractors or material suppliers that Landlord reasonably believes could cause labor disharmony. All Tenant contracts related to the Extension Tenant Improvements shall provide
that Tenant may assign such contracts and any warranties with respect to the Extension Tenant Improvements to Landlord at any time. 
 2. Extension
Tenant Improvements. All Extension Tenant Improvements shall be performed by Tenant’s contractor, at Tenant’s sole cost and expense (subject to Landlord’s obligations with respect to any portion of the Extension TI Allowance) and
in accordance with the Approved Plans (as defined below), the Lease and this Extension Work Letter. If Tenant fails to pay, or is late in paying, any sum due to Landlord under Section 4 of the Amendment or this Extension Work Letter,
then Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including the right to interest and the right to assess a late charge), and for purposes of any litigation instituted with regard to such amounts
the same shall be considered Rent. All material and equipment furnished by Tenant or its contractors as the Extension Tenant Improvements shall be new or “like new;” the Extension Tenant Improvements shall be performed in a first-class,
workmanlike manner; and the quality of the Extension Tenant Improvements shall be of a nature and character not less than the Building Standard. Tenant shall take, and shall require its contractors to take, commercially reasonable steps to protect
the Premises during the performance of any Extension Tenant Improvements, including covering or temporarily removing any window coverings so as to guard against dust, debris or damage. 

2.1 Work Plans. Tenant shall prepare and submit to Landlord for approval (such approval not to be unreasonably withheld, conditioned or
delayed) schematics covering the Extension Tenant Improvements prepared in conformity with the applicable provisions of this Extension Work Letter (the “Draft Schematic Plans”). The Draft Schematic Plans shall contain sufficient
information and detail to accurately describe the proposed design to Landlord and such other information as Landlord may reasonably request. Landlord shall notify Tenant in writing within ten (10) business days after receipt of the Draft
Schematic Plans whether Landlord approves or objects to the Draft Schematic Plans and of the manner, if any, in which the Draft Schematic Plans are unacceptable. Landlord’s failure to respond within such ten (10) business day period shall
be deemed approval by Landlord. If Landlord reasonably objects to the Draft Schematic Plans, then Tenant shall revise the Draft Schematic Plans and cause Landlord’s objections to be remedied in the revised Draft Schematic Plans. Tenant shall
then resubmit the revised Draft Schematic Plans to Landlord for approval, such approval not to be unreasonably withheld, conditioned or delayed. Landlord’s approval of or objection to revised Draft Schematic Plans and Tenant’s correction
of the 

  
 -41- 

 
same shall be in accordance with this Section until Landlord has approved the Draft Schematic Plans in writing or been deemed to have approved them. The iteration of the Draft Schematic
Plans that is approved or deemed approved by Landlord without objection shall be referred to herein as the “Approved Schematic Plans.” 

2.2 Construction Plans. Tenant shall prepare final plans and specifications for the Extension Tenant Improvements that (a) are
consistent with and are logical evolutions of the Approved Schematic Plans and (b) incorporate any other Tenant-requested (and Landlord-approved) Changes (as defined below). As soon as such final plans and specifications (“Construction
Plans”) are completed, Tenant shall deliver the same to Landlord for Landlord’s approval, which approval shall not be unreasonably withheld, conditioned or delayed. Such Construction Plans shall be approved or disapproved by Landlord
within ten (10) business days after delivery to Landlord. Landlord’s failure to respond within such ten (10) business day period shall be deemed approval by Landlord. If the Construction Plans are disapproved by Landlord, then
Landlord shall notify Tenant in writing of its objections to such Construction Plans, and the parties shall confer and negotiate in good faith to reach agreement on the Construction Plans. Promptly after the Construction Plans are approved by
Landlord and Tenant, two (2) copies of such Construction Plans shall be initialed and dated by Landlord and Tenant, and Tenant shall promptly submit such Construction Plans to all appropriate Governmental Authorities for approval. The
Construction Plans so approved, and all change orders specifically permitted by this Extension Work Letter, are referred to herein as the “Approved Plans.” 

2.3 Changes to the Extension Tenant Improvements. Any changes to the Approved Plans (each, a “Change”) shall be
requested and instituted in accordance with the provisions of this Article 2 and shall be subject to the written approval of the non-requesting party in accordance with this Extension Work Letter. 

(a) Change Request. Either Landlord or Tenant may request Changes after Landlord approves the Approved Plans by notifying the other
party thereof in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request shall detail the nature and extent of any requested Changes, including (i) the Change,
(ii) the party required to perform the Change and (iii) any modification of the Approved Plans and the Schedule, as applicable, necessitated by the Change. If the nature of a Change requires revisions to the Approved Plans, then the
requesting party shall be solely responsible for the cost and expense of such revisions and any increases in the cost of the Extension Tenant Improvements as a result of such Change; provided that if Tenant requests the Change, then Tenant
may utilize the Extension TI Allowance. Change Requests shall be signed by the requesting party’s Authorized Representative. 
 (b)
Approval of Changes. All Change Requests shall be subject to the other party’s prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed. The non-requesting party shall have five (5) business
days after receipt of a Change Request to notify the requesting party in writing of the non-requesting party’s decision either to approve or object to the Change Request. The non-requesting party’s failure to respond within such five
(5) business day period shall be deemed approval by the non-requesting party. 

  
 -42- 

 2.4 Preparation of Estimates. Tenant shall, before proceeding with any Change, using its
best efforts, prepare as soon as is reasonably practicable (but in no event more than five (5) business days after delivering a Change Request to Landlord or receipt of a Change Request) an estimate of the increased costs or savings that would
result from such Change, as well as an estimate on such Change’s effects on the Schedule. Landlord shall have five (5) business days after receipt of such information from Tenant to (a) in the case of a Tenant-initiated Change
Request, approve or reject such Change Request in writing, or (b) in the case of a Landlord-initiated Change Request, notify Tenant in writing of Landlord’s decision either to proceed with or abandon the Landlord-initiated Change Request.

 3. Completion of Extension Tenant Improvements. Tenant, at its sole cost and expense (except for the Extension TI Allowance and the Extension Test
Fit Allowance), shall perform and complete the Extension Tenant Improvements in all respects (a) in substantial conformance with the Approved Plans, (b) otherwise in compliance with provisions of the Lease and this Extension Work Letter
and (c) in accordance with Applicable Laws, the requirements of Tenant’s insurance carriers, the requirements of Landlord’s insurance carriers (to the extent Landlord provides its insurance carriers’ requirements to Tenant prior
to the signing of a contract with the general contractor) and the board of fire underwriters having jurisdiction over the Premises. “Substantial Completion” shall be deemed to have occurred upon Tenant’s providing the following
to Landlord: (i) evidence reasonably satisfactory to Landlord that the Extension Tenant Improvements have been paid for in full, which shall be evidenced by the architect’s certificate of completion and the general contractor’s and
each subcontractor’s and material supplier’s final unconditional waivers and releases of liens, each in a form reasonably acceptable to Landlord; provided, however, with respect to subcontractors and material suppliers providing less than
$50,000 in the aggregate of labor, materials or services, Tenant shall not be required to provide lien waivers and releases so long as the total amount of the unpaid labor, services and materials for all subcontractors for which no lien releases
have been obtained, is less than $50,000 in the aggregate, (ii) a certificate of occupancy for the Premises issued by the City of Seattle, (iii) a Certificate of Substantial Completion in the form of the American Institute of Architects
document G704 or other reasonable form, executed by the project architect and the general contractor, (iv) any and all liens related to the Extension Tenant Improvements have either been discharged of record (by payment, bond, order of a court
of competent jurisdiction or otherwise) or waived by the party filing such lien, (v) an affidavit from Tenant’s architect certifying that all work performed in, on or about the Premises is substantially in accordance with the Approved
Plans, (vi) a complete “as built” drawing print sets, project specifications and shop drawings and electronic CADD files on disc (showing the Extension Tenant Improvements as an overlay on the Building “as built” plans
(provided that Landlord provides the Building “as-built” plans provided to Tenant) of all contract documents for work performed by their architect and engineers in relation to the Extension Tenant Improvements, (vii) a
commissioning report prepared by a licensed, qualified commissioning agent hired by Tenant and reasonably acceptable to Landlord for all new or affected mechanical, electrical and plumbing systems, and (viii) such other “close out”
materials as Landlord reasonably requests consistent with Landlord’s own requirements for its contractors, such as copies of manufacturers’ warranties, operation and maintenance manuals and the like. 

  
 -43- 

 4. Insurance. 

4.1 Property Insurance. At all times during the period beginning with commencement of construction of the Extension Tenant Improvements
and ending with final completion of the Extension Tenant Improvements, Tenant shall maintain, or cause to be maintained (in addition to the insurance required of Tenant pursuant to the Lease), property insurance coverage with respect to the general
contractor’s and any subcontractors’ machinery, tools and equipment. Coverage shall be carried on a primary basis by such general contractor or the applicable subcontractor(s). Tenant agrees to pay any deductible, and Landlord is not
responsible for any deductible, for a claim under such insurance, except to the extent caused by Landlord’s negligence or intentional misconduct. Tenant shall use reasonable efforts to require that such property insurance shall contain an
express waiver of any right of subrogation by the insurer against Landlord and the Landlord Parties, and shall name Landlord and its affiliates as loss payees as their interests may appear. 

4.2 Workers’ Compensation Insurance. At all times during the period of construction of the Extension Tenant Improvements, Tenant
shall, or shall cause its contractors or subcontractors to, maintain statutory workers’ compensation insurance as required by Applicable Laws. 
 5.
Liability. Except to the extent caused by Landlord’s negligence or intentional misconduct or covered by property insurance actually carried by Landlord (or that would have been covered by Landlord’s property insurance had Landlord
carried the property insurance required under the Lease), Tenant assumes sole responsibility and liability for any and all injuries or the death of any persons, including Tenant’s contractors and subcontractors and their respective employees,
agents and invitees, and for any and all damages to property caused by, resulting from or arising out of any act or omission on the part of Tenant, Tenant’s contractors or subcontractors, or their respective employees, agents and invitees in
the prosecution of the Extension Tenant Improvements. Tenant agrees to indemnify, save, defend (at Landlord’s option and with counsel reasonably acceptable to Landlord) and hold the Landlord Indemnitees harmless from and against all Claims due
to, because of or arising out of any and all such injuries, death or damage, whether real or alleged, and Tenant and Tenant’s contractors and subcontractors shall assume and defend at their sole cost and expense all such Claims;
provided, however, that nothing contained in this Extension Work Letter shall be deemed to indemnify or otherwise hold Landlord harmless from or against liability caused by Landlord’s negligence or willful misconduct. Any
deficiency in design or construction of the Extension Tenant Improvements shall be solely the responsibility of Tenant, notwithstanding the fact that Landlord may have approved of the same in writing. 

6. Extension TI Allowance. 
 6.1
Application of Extension Test Fit Allowance and Extension TI Allowance. Landlord shall contribute the Extension Test Fit Allowance towards the cost of a test fit plan for the Premises, and Landlord shall contribute the Extension TI Allowance
toward the costs and expenses incurred in connection with the performance of the Extension Tenant Improvements, all in accordance with Section 6 of the Amendment. Subject to Tenant’s TI Allowance Reallocation Right, if the entire
Extension Test Fit Allowance is not applied toward the cost of the test fit plan, or if the entire Extension TI Allowance is not applied toward or reserved for the costs of the Extension Tenant 

  
 -44- 

 
Improvements, then Tenant shall not be entitled to a credit of such unused portion of the Extension Test Fit Allowance or the Extension TI Allowance. Tenant may apply the Extension Test Fit
Allowance for the payment of the test fit plan costs and may apply the Extension TI Allowance for the payment of construction and other costs, in accordance with the terms and provisions of the Lease. 

6.2 Approval of Budget for the Extension Tenant Improvements. Notwithstanding anything to the contrary set forth elsewhere in this
Extension Work Letter or the Lease, Landlord shall not have any obligation to expend any portion of the Extension TI Allowance until Landlord and Tenant shall have approved in writing the budget for the Extension Tenant Improvements (the
“Approved Budget”). Prior to Landlord’s approval of the Approved Budget, Tenant shall pay all of the costs and expenses incurred in connection with the Extension Tenant Improvements as they become due. Landlord shall not be
obligated to reimburse Tenant for costs or expenses relating to the Extension Tenant Improvements that exceed the amount of the Extension TI Allowance. Landlord shall not unreasonably withhold, condition or delay its approval of any budget for
Extension Tenant Improvements that is proposed by Tenant. 
 6.3 Fund Requests. 

(a) Extension Test Fit Allowance. Upon submission by Tenant to Landlord of an itemized invoice for the test fit plan costs, then
Landlord shall, within thirty (30) days following receipt of such invoice, pay to the applicable architect the amount of the test fit plan costs, up to the amount of the Extension Test Fit Allowance. 

(b) Extension TI Allowance. Tenant may periodically (but no more frequently than monthly) submit written requests for disbursements of
the Extension TI Allowance. Each request for funding (a “Fund Request”) shall include the following: (i) the total amount of the Extension TI Allowance requested, (ii) a summary of the Extension Tenant Improvements
performed using AIA standard form Application for Payment (G 702) executed by the general contractor and by the architect or other reasonable form, (iii) invoices from the general contractor, the architect, and any subcontractors, material
suppliers and other parties requesting payment with respect to the amount of the Extension TI Allowance then being requested, (iv) unconditional lien releases from the general contractor and each subcontractor and material supplier with respect
to previous payments made by either Landlord or Tenant for the Extension Tenant Improvements in a form reasonably acceptable to Landlord and complying with Applicable Laws, and (v) conditional lien releases from the general contractor and each
subcontractor and material supplier with respect to the Extension Tenant Improvements performed that correspond to the Fund Request, each in a form reasonably acceptable to Landlord and complying with Applicable Laws; provided, however, for purposes
of clauses (iv) and (v) above, with respect to subcontractors and material suppliers providing less than $50,000 in the aggregate of labor, materials or services, Tenant shall not be required to provide lien releases so long as the total
amount of the unpaid labor, services and materials for all subcontractors for which no lien releases have been obtained, is less than $50,000 in the aggregate. Within thirty (30) days following receipt by Landlord of a Fund Request and the
accompanying materials required by this Section, Landlord shall pay to (as elected by Tenant) the 

  
 -45- 

 
applicable contractors, subcontractors and material suppliers or Tenant the amount of Extension Tenant Improvement costs set forth in such Fund Request; provided, however, that
Landlord shall not be obligated to make any payments under this Section until the budget for the Extension Tenant Improvements is approved in accordance with Section 6.2, and any Fund Request under this Section shall be subject
to the payment limits set forth in Section 6.2 above and Section 6 of the Amendment. 
 6.4 Accrual Information. In
addition to the other requirements of this Section 6, Tenant shall, no more often than once every calendar quarter during construction of the Extension Tenant Improvements, provide Landlord with a written summary of all work performed by
Tenant or its agents, employees or contractors for which a Fund Request has not yet been issued to Landlord, including the following: the amount that Tenant will seek from Landlord related to such work and the dates on which such work was performed.
Such information shall be provided to Landlord within ten (10) business days after Landlord’s request therefor. 
 7. Miscellaneous. 

7.1 Incorporation of Lease Provisions. Sections 18.1 through 18.3, Section 18.5,
Sections 18.7 through 18.10, Sections 41.1, 41.3 through 41.7, 41.9 through 41.13, and 41.15 of the Lease are incorporated into this Extension Work Letter by reference, and shall
apply to this Extension Work Letter in the same way that they apply to the Lease. 
 7.2 General. Except as otherwise set forth in
the Lease or this Extension Work Letter, this Extension Work Letter shall not apply to improvements performed in any additional premises added to the Premises at any time or from time to time, whether by any options under the Lease or otherwise; or
to any portion of the Premises or any additions to the Premises in the event of a renewal or extension of the original Term, whether by any options under the Lease or otherwise, unless the Lease or any amendment or supplement to the Lease expressly
provides that such additional premises are to be delivered to Tenant in the same condition as the initial Premises. 
 [REMAINDER OF THIS
PAGE INTENTIONALLY LEFT BLANK] 

  
 -46- 

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Extension Work Letter to be effective
on the date first above written. 
 LANDLORD: 
 BMR-530
FAIRVIEW AVENUE LLC, 
 a Delaware limited liability company 
  

			
		
	By:		/s/ Kevin Simonsen
		
	Name:		Kevin M. Simonsen
		
	Title:		VP, Real Estate Legal

 TENANT: 
 NANOSTRING
TECHNOLOGIES, INC., 
 a Delaware corporation 
  

			
		
	By:		/s/ Wayne D. Burns
		
	Name:		Wayne D. Burns
		
	Title:		Sr. VP, Operations & Administration

  
 -47- 

 EXHIBIT C-1 

TENANT WORK INSURANCE SCHEDULE 

Tenant shall be responsible for requiring all of Tenant contractors doing construction or renovation work to purchase and maintain such insurance as shall
protect it from the claims set forth below which may arise out of or result from any Extension Tenant Improvements (collectively, “Tenant Work”) whether such Tenant Work is completed by Tenant or by any Tenant contractors or by any
person directly or indirectly employed by Tenant or any Tenant contractors, or by any person for whose acts Tenant or any Tenant contractors may be liable: 

1. Claims under workers’ compensation, disability benefit and other similar employee benefit acts which are applicable to the Tenant Work to be
performed. 
 2. Claims for damages because of bodily injury, occupational sickness or disease, or death of employees under any applicable employer’s
liability law. 
 3. Claims for damages because of bodily injury, or death of any person other than Tenant’s or any Tenant contractors’ employees.

 4. Claims for damages insured by usual personal injury liability coverage which are sustained (a) by any person as a result of an offense directly
or indirectly related to the employment of such person by Tenant or any Tenant contractors or (b) by any other person. 
 5. Claims for damages, other
than to the Tenant Work itself, because of injury to or destruction of tangible property, including loss of use therefrom. 
 6. Claims for damages because
of bodily injury or death of any person or property damage arising out of the ownership, maintenance or use of any motor vehicle. 
 Tenant
contractors’ Commercial General Liability Insurance shall include premises/operations (including explosion, collapse and underground coverage if such Tenant Work involves any underground work), elevators, independent contractors, products and
completed operations, and blanket contractual liability on all written contracts, all including broad form property damage coverage. 

Tenant contractors’ Commercial General, Automobile, Employers and Umbrella Liability Insurance shall be written for not less than limits
of liability as follows: 
  

					
	a.        		 Commercial General Liability:
 Bodily Injury and
Property
 Damage
		Commercially reasonable amounts, but in any event no less than $1,000,000 per occurrence and $2,000,000 general aggregate, with $2,000,000 products and completed operations
aggregate.

  
 -48- 

					
			
	b.		 Commercial General Liability:
 Bodily Injury and
Property
 Damage
		$1,000,000 per accident
			
	c.		 Employer’s Liability:
  

        Each Accident
  

        Disease – Policy Limit
  

        Disease – Each Employee
		 $500,000
  

$500,000
  

$500,000

			
	d.		Umbrella Liability:		Commercially reasonable amounts (excess of coverages a, b and c above), but in any event no less than $5,000,000 per occurrence / aggregate.

 All subcontractors for Tenant contractors shall carry the same coverages and limits as specified above, unless different
limits are reasonably approved by Landlord. The foregoing policies shall contain a provision that coverages afforded under the policies shall not be canceled or not renewed until at least thirty (30) days’ prior written notice has been
given to the Landlord. Certificates of insurance including required endorsements showing such coverages to be in force shall be filed with Landlord prior to the commencement of any Tenant Work and prior to each renewal. Coverage for completed
operations must be maintained for the lesser of ten (10) years and the applicable statue of repose following completion of the Tenant Work, and certificates evidencing this coverage must be provided to Landlord. The minimum A.M. Best’s
rating of each insurer shall be A- VII. Landlord and its mortgagees shall be named as an additional insureds under Tenant contractors’ Commercial General Liability, Commercial Automobile Liability and Umbrella Liability Insurance policies as
respects liability arising from work or operations performed, or ownership, maintenance or use of autos, by or on behalf of such contractors. Each contractor and its insurers shall provide waivers of subrogation with respect to any claims covered or
that should have been covered by valid and collectible insurance, including any deductibles or self-insurance maintained thereunder. 
 If any
contractor’s work involves the handling or removal of asbestos (as determined by Landlord in its sole and absolute discretion), such contractor shall also carry Pollution Legal Liability insurance. Such coverage shall include bodily injury,
sickness, disease, death or mental anguish or shock sustained by any person; property damage, including physical injury to or destruction of tangible property (including the resulting loss of use thereof), clean-up costs and the loss of use of
tangible property that has not been physically injured or destroyed; and defense costs, charges and expenses incurred in the investigation, adjustment or defense of claims for such damages. Coverage shall apply to both sudden and non-sudden
pollution conditions including the discharge, dispersal, release or escape of smoke, vapors, soot, fumes, acids, alkalis, toxic chemicals, liquids or gases, waste materials or other irritants, contaminants or pollutants into or upon land, the
atmosphere or any watercourse or body of water. Claims-made coverage is permitted, provided the policy retroactive 

  
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date is continuously maintained prior to the Term Commencement Date, and coverage is continuously maintained during all periods in which Tenant occupies the Premises. Coverage shall be maintained
with limits of not less than $1,000,000 per incident with a $2,000,000 policy aggregate. 

  
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 EXHIBIT D 

TI ALLOWANCE REALLOCATION AGREEMENT 

THIS TI ALLOWANCE REALLOCATION AGREEMENT (this “Agreement”) is entered into as of this ___ day of December, 2014, by and between
BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), BMR-500 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“500 Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware
corporation (“Tenant”), and is attached to and made a part of that certain Seventh Amendment to Lease dated of even date herewith by and between Landlord and Tenant, amending that certain Lease dated as of October 19, 2007 (as
the same may have been or may be amended, amended and restated, supplemented or otherwise modified from time to time, including by the Amendment, the “Lease”), for the Premises located at 530 Fairview Avenue North, Seattle,
Washington 98109. All capitalized terms used but not otherwise defined herein shall have the meanings given them in the Lease. 

RECITALS 
 A.
WHEREAS, pursuant to the Lease, Landlord has agreed to contribute a tenant improvement allowance in the amount of One Million Eighty-Eight Thousand Forty and No/100 Dollars ($1,088,040.00) (the “Extension TI Allowance”) to be used
for the construction of certain tenant improvements (the “Extension Tenant Improvements”) in the Premises by Tenant; and 

B. WHEREAS, pursuant to the Adjacent Building Lease, 500 Landlord has agreed to contribute a tenant improvement allowance in the amount of Two
Million Five Hundred Ninety Thousand Five Hundred Ten and No/100 Dollars ($2,590,510.00) (the “500 TI Allowance”) to be used for the construction of the 500 Tenant Improvements in the Adjacent Building Premises by Tenant; and 

C. WHEREAS, Tenant has requested, and Landlord and 500 Landlord have agreed to grant to Tenant, the TI Allowance Reallocation Right, on the
terms and conditions set forth in the Lease and in this Agreement. 
 AGREEMENT 

NOW, THEREFORE, Landlord, 500 Landlord and Tenant, in consideration of the Recitals set forth above which are incorporated herein by this
reference, and in consideration of mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 

1. Reallocation of Extension TI Allowance. If the cost of the 500 Tenant Improvements exceeds the amount of the 500 TI Allowance, then Tenant shall
have the right (the “TI Allowance Reallocation Right”) to reallocate a portion of any unused Extension TI Allowance to pay such excess cost of the 500 Tenant Improvements up to three (3) times (subject to the limitations set
forth in the Adjacent Building Lease Amendment), provided, however, that all of the following conditions must be satisfied at the time that Tenant exercises the Extension TI Allowance Relocation Right: 

(a) Tenant shall have expended all of the 500 TI Allowance; 

  
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 (b) Tenant shall have delivered to Landlord, no later than the Extension TI Deadline, a written
request to reallocate a portion of the unused Extension TI Allowance to pay the remaining cost to complete the construction of the 500 Tenant Improvements, setting forth the amount of the Extension TI Allowance that Tenant desires to reallocate (the
“Reallocated TI Allowance Amount”); and 
 (c) Tenant shall not be in default beyond any applicable notice and cure periods
under either the Lease or the Adjacent Building Lease. 
 2. Effect of Extension TI Allowance Reallocation. Immediately upon
Tenant’s exercise of the TI Allowance Reallocation Right in accordance with Section 1 above, (a) the Extension TI Allowance shall be reduced by the Reallocated TI Allowance Amount, and Landlord shall have no further obligation
to fund the Reallocated TI Allowance Amount for the performance of the Extension Tenant Improvements, and (b) the 500 TI Allowance shall be increased by the Reallocated TI Allowance Amount, and 500 Landlord shall be obligated to disburse the
Reallocated TI Allowance Amount to pay the cost of the 500 Tenant Improvements in accordance with and subject to the limitations of the Adjacent Building Lease. 

3. Time of the Essence. Time shall be of the essence with respect to Tenant’s exercise of the TI Allowance Reallocation Right.
Tenant acknowledges that it would be inequitable to require Landlord to accept any exercise of the TI Allowance Reallocation Right after the Extension TI Deadline. The period of time within which Tenant may exercise the TI Allowance Reallocation
Right shall not be extended or enlarged by reason of Tenant’s inability to exercise the TI Allowance Reallocation Right due to a failure of any of the conditions set forth in Section 1 above. 

4. Incorporation of Lease Provisions. Sections 41.1, 41.3 through 41.7, 41.9 through 41.13, and
41.15 of the Lease are incorporated into this Agreement by reference, and shall apply to this Agreement in the same way that they apply to the Lease. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, Landlord, 500 Landlord and Tenant have executed this Agreement to be
effective on the date first above written. 
 LANDLORD: 

BMR-530 FAIRVIEW AVENUE LLC, 
 a Delaware limited liability
company 
  

			
		
	By: 		 
		
	Name: 		 
		
	Title: 		 

 500 LANDLORD: 
 BMR-500
FAIRVIEW AVENUE LLC, 
 a Delaware limited liability company 
  

			
		
	By: 		 
		
	Name: 		 
		
	Title: 		 

 TENANT: 
 NANOSTRING
TECHNOLOGIES, INC., 
 a Delaware corporation 
  

			
		
	By: 		 
		
	Name:		 
		
	Title: 		 

  
 -53-

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