Document:

EX-10.1

 EXHIBIT 10.1 

SECOND AMENDED AND RESTATED 2005 EMPLOYMENT AGREEMENT 

This Second Amended and Restated 2005 Employment Agreement (this “Agreement”) is made as of the 20th day of May, 2014 by and between
Integra LifeSciences Holdings Corporation, a Delaware Corporation (the “Company”) and John B. Henneman, III (“Executive”). 

Background 
 The Company
and Executive previously entered into that certain Amended and Restated 2005 Employment Agreement, dated as of December 19, 2005, as amended by Amendment 2008-1, Amendment 2008-2, Amendment 2009-1 and Amendment 2010-1 thereto, and that certain
letter agreement dated as of February 22, 2012 (collectively, the “Original Agreement”) pursuant to which Executive serves as the Chief Financial Officer of the Company. Effective as of May 2, 2014 (the “Amended Effective
Date”), the Company desires to continue to employ Executive, and Executive desires to remain in the employ of the Company, as Corporate Vice President and Chief Administrative Officer of the Company, on the terms and conditions contained in
this Agreement. Executive has been and will continue to be substantially involved with the Company’s operations and management and has learned and will continue to learn trade secrets and other confidential information relating to the Company
and its customers; accordingly, the noncompetition covenant and other restrictive covenants contained in Section 16 of this Agreement constitute essential elements hereof. 

NOW, THEREFORE, in consideration of the premises and the mutual agreements contained herein and intended to be legally bound hereby, the
parties hereto agree as follows: 
 Terms 

1. Definitions. The following words and phrases shall have the meanings set forth below for the purposes of this Agreement (unless the
context clearly indicates otherwise): 
  

	 	(a)	“Base Salary” shall have the meaning set forth in Section 5. 

  

	 	(b)	“Board” shall mean the Board of Directors of the Company, or any successor thereto. 

  

	 	(c)	“Cause,” as determined by the Board in good faith, shall mean Executive has — 

  

	 	(1)	failed to perform his stated duties in all material respects, which failure continues for 15 days after his receipt of written notice of the failure; 

 

	 	(2)	intentionally and materially breached any provision of this Agreement and not cured such breach (if curable) within 15 days of his receipt of written notice of the breach; 

	 	(3)	demonstrated his personal dishonesty in connection with his employment by the Company; 

  

	 	(4)	engaged in a breach of fiduciary duty in connection with his employment with the Company; 

  

	 	(5)	engaged in willful misconduct that is materially and demonstrably injurious to the Company or any of its subsidiaries; or 

  

	 	(6)	conviction or plea of guilty or nolo contendere to a felony or to any other crime involving moral turpitude which conviction or plea is materially and demonstrably injurious to the Company or any of its subsidiaries.

  

	 	(d)	A “Change in Control” of the Company shall be deemed to have occurred: 

  

	 	(1)	if the “beneficial ownership” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934) of securities representing more than fifty percent (50%) of the combined voting power of Company Voting
Securities (as herein defined) is acquired by any individual, entity or group (a “Person”), other than the Company, any trustee or other fiduciary holding securities under any employee benefit plan of the Company or an affiliate thereof,
or any corporation owned, directly or indirectly, by the stockholders of the Company in substantially the same proportions as their ownership of stock of the Company (for purposes of this Agreement, “Company Voting Securities” shall mean
the then outstanding voting securities of the Company entitled to vote generally in the election of directors); provided, however, that any acquisition from the Company or any acquisition pursuant to a transaction which complies with clauses (i),
(ii) and (iii) of paragraph (3) of this definition shall not be a Change in Control under this paragraph (1); or 

  

	 	(2)	if individuals who, as of the date hereof, constitute the Board (the “Incumbent Board”) cease for any reason during any period of at least 24 months to constitute at least a majority of the Board; provided,
however, that any individual becoming a director subsequent to the date hereof whose election, or nomination for election by the Company’s stockholders, was approved by a vote of at least a majority of the directors then comprising the
Incumbent Board shall be considered as though such individual were a member of the Incumbent Board, but excluding, for this purpose, any such individual whose initial assumption of office occurs as a result of an actual or threatened election
contest with respect to the election or removal of directors or other actual or threatened solicitation of proxies or consents by or on behalf of a Person other than the Board; or 

  
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	 	(3)	upon consummation by the Company of a reorganization, merger or consolidation or sale or other disposition of all or substantially all of the assets of the Company or the acquisition of assets or stock of any entity (a
“Business Combination”), in each case, unless immediately following such Business Combination: (i) Company Voting Securities outstanding immediately prior to such Business Combination (or if such Company Voting Securities were
converted pursuant to such Business Combination, the shares into which such Company Voting Securities were converted) (x) represent, directly or indirectly, more than 50% of the combined voting power of the then outstanding voting securities
entitled to vote generally in the election of directors of the corporation resulting from such Business Combination (the “Surviving Corporation”), or, if applicable, a corporation which as a result of such transaction owns the Company or
all or substantially all of the Company’s assets either directly or through one or more subsidiaries (the “Parent Corporation”) and (y) are held in substantially the same proportions after such Business Combination as they were
immediately prior to such Business Combination; (ii) no Person (excluding any employee benefit plan (or related trust) of the Company or such corporation resulting from such Business Combination) beneficially owns, directly or indirectly, 50%
or more of the combined voting power of the then outstanding voting securities eligible to elect directors of the Parent Corporation (or, if there is no Parent Corporation, the Surviving Corporation) except to the extent that such ownership of the
Company existed prior to the Business Combination; and (iii) at least a majority of the members of the board of directors of the Parent Corporation (or, if there is no Parent Corporation, the Surviving Corporation) were members of the Incumbent
Board at the time of the execution of the initial agreement, or the action of the Board, providing for such Business Combination; or 

  

	 	(4)	upon approval by the stockholders of the Company of a complete liquidation or dissolution of the Company. 

  

	 	(e)	“Code” shall mean the Internal Revenue Code of 1986, as amended. 

  

	 	(f)	“Company” shall mean Integra LifeSciences Holdings Corporation and any corporation, partnership or other entity owned directly or indirectly, in whole or in part, by Integra LifeSciences Holdings Corporation.

  
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	 	(g)	“Definitive Agreement” means an agreement entered into by the Company which, if the transactions contemplated thereby were consummated, would result in a Change in Control. 

 

	 	(h)	“Disability” shall mean Executive’s inability to perform his duties hereunder by reason of any medically determinable physical or mental impairment which is expected to result in death or which has lasted
or is expected to last for a continuous period of not fewer than six months. 

  

	 	(i)	“Good Reason” shall mean: 

  

	 	(1)	a material breach of this Agreement by the Company which is not cured by the Company within 15 days of its receipt of written notice of the breach; 

 

	 	(2)	the relocation by the Company of Executive’s primary place of employment to a location more than forty (40) miles from Austin, Texas; 

 

	 	(3)	without Executive’s express written consent, the Company reduces Executive’s Base Salary or bonus opportunity, or materially reduces the aggregate fringe benefits provided to Executive (except to the extent
permitted by Sections 5, 6 or 7, respectively) or substantially alters Executive’s authority and/or title as set forth in Section 2 hereof in a manner reasonably construed to constitute a demotion, provided, Executive resigns within 90
days after the change objected to; 

  

	 	(4)	without Executive’s express written consent, Executive fails at any point during the one-year period following a Change in Control to hold the title and authority (as set forth in Section 2 hereof) with the
Parent Corporation (or if there is no Parent Corporation, the Surviving Corporation) that Executive held with the Company immediately prior to the Change of Control, provided Executive resigns within one year of the Change in Control; or

  

	 	(5)	the Company fails to obtain the assumption of this Agreement by any successor to the Company; 

provided, however, that, notwithstanding the foregoing, Executive hereby expressly consents to the amendments to the Original Agreement
contained in this Agreement, including, without limitation, the changes to his position, compensation and office location, and further agrees that neither such changes nor any action taken by the Company in connection therewith (including the
appointment of a new Chief Financial Officer of the Company) shall constitute a breach of, or “Good Reason” for purposes of, this Agreement or any other agreement between Executive and the Company or its affiliates. 

  
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	 	(j)	“Termination Date” shall mean the date specified in the Termination Notice. 

  

	 	(k)	“Termination Notice” shall mean a dated notice which: (i) indicates the specific termination provision in this Agreement relied upon (if any); (ii) sets forth in reasonable detail the facts and
circumstances claimed to provide a basis for the termination of Executive’s employment under such provision; (iii) specifies a Termination Date; and (iv) is given in the manner specified in Section 17(i). 

2. Employment. Effective as of the Amended Effective Date, the Company hereby employs Executive as Corporate Vice President and Chief
Administrative Officer, and Executive hereby agrees to accept such employment and agrees to render services to the Company in such capacity (or in such other capacity in the future as the Board may reasonably deem equivalent to such position) on the
terms and conditions set forth in this Agreement. Executive’s primary place of employment shall be at the Company’s office located in Austin, Texas, and Executive shall report to the Chief Executive Officer. 

3. Term of Agreement. Unless earlier terminated by Executive or the Company as provided in Section 12 hereof, the term of
Executive’s employment under this Agreement shall commence on the Amended Effective Date and terminate on September 30, 2014 (the “Term”). Unless earlier terminated, Executive’s employment with the Company shall
automatically and without further action terminate on September 30, 2014. 
 4. Duties. Executive shall: 

 

	 	(a)	faithfully and diligently do and perform all such acts and duties, and furnish such services as are assigned to Executive as of the Amended Effective Date, and (subject to Section 2) such additional acts, duties
and services as the Chief Executive Officer or the Board may assign in the future; and 

  

	 	(b)	devote his full professional time, energy, skill and best efforts to the performance of his duties hereunder, in a manner that will faithfully and diligently further the business and interests of the Company, and shall
not be employed by or participate or engage in or in any manner be a part of the management or operations of any business enterprise other than the Company without the prior consent of the Chief Executive Officer or the Board, which consent may be
granted or withheld in his or its sole discretion; provided, however, that notwithstanding the foregoing, Executive may serve on civic or charitable boards or committees so long as such service does not materially interfere with Executive’s
obligations pursuant to this Agreement. 

 5. Compensation. As of the Amended Effective Date, Executive’s base
salary rate is equal to $561,000 per annum. Executive’s base salary, as determined in accordance with this Section 5 and as may be increased from time to time, is hereinafter referred to as his “Base Salary.” Executive’s
Base Salary shall be payable in periodic installments in accordance with the Company’s regular payroll practices in effect from time to time. Executive’s Base Salary shall be subject to annual reviews, but may not be decreased without
Executive’s express written consent. 

  
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 6. 2014 Bonus Opportunity. Provided that Executive remains employed by the Company until
September 30, 2014, for the Company’s 2014 fiscal year, Executive shall have the opportunity to receive an annual performance bonus (the “2014 Annual Bonus”) targeted at 90% of Executive’s Base Salary, payable based upon the
satisfaction of certain performance objectives as determined by the Compensation Committee of the Board (the “Compensation Committee”), in its sole discretion, pro-rated to reflect the number of days that Executive was employed by the
Company during the 2014 fiscal year. Payment of the 2014 Annual Bonus, to the extent it becomes payable, shall occur no later than March 15, 2015. 

7. Benefit Plans. Executive shall be entitled to participate in and receive benefits under any employee benefit plan of the Company in
accordance with their terms, and shall be eligible for any other plans and benefits covering executives of the Company, to the extent commensurate with his then duties and responsibilities fixed by the Board, Compensation Committee or Chief
Executive Officer. The Company shall not make any change in such plans or benefits that would adversely affect Executive’s rights thereunder, unless such change affects all, or substantially all, executive officers of the Company. 

8. Equity Compensation. 
  

	 	(a)	Outstanding Equity Awards. Effective as of the third business day following the date of this Agreement, (1) each outstanding time- vesting restricted stock award held by Executive as of the Amended Effective
Date shall vest in full, and (2) with respect to each outstanding award of performance stock held by Executive as of the Amended Effective Date, any continued employment or service requirements shall be deemed satisfied and each such award
shall remain outstanding and eligible to vest in accordance with the terms and conditions set forth in the applicable award agreement (other than terms and conditions relating to any continued employment or service requirements). 

 

	 	(b)	S-8. The Company agrees that for so long as it is required to file reports under Sections 13 or 15(d) of the Securities Exchange Act of 1934, it will maintain in effect a Form S-8 registration statement covering
the issuance to Executive of the shares underlying Executive’s then outstanding equity-based compensation awards. 

 9.
Vacation. Executive shall be entitled to paid annual vacation in accordance with the policies established from time to time by the Board, which shall in no event be fewer than four weeks per annum. 

  
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 10. Business Expenses. The Company shall reimburse Executive or otherwise pay for all
reasonable expenses incurred by Executive in furtherance of or in connection with the business of the Company, including, but not limited to, automobile and traveling expenses (including travel to the Company’s principal headquarters in New
Jersey) and all reasonable entertainment expenses, subject to such reasonable documentation and other limitations as may be established by the Company. 

11. Disability. In the event Executive incurs a Disability, Executive’s obligation to perform services under this Agreement will
terminate, and the Board may terminate this Agreement upon written notice to Executive. 
 12. Termination. 

 

	 	(a)	Termination for Cause or without Good Reason. In the event (i) Executive terminates his employment hereunder other than for Good Reason, or (ii) Executive’s employment is terminated by the Company
for Cause, Executive shall have no right to compensation or other benefits pursuant to this Agreement for any period after his last day of active employment. 

  

	 	(b)	Qualifying Termination (No Change in Control). Subject to Executive and the Company executing, within 30 days after the Termination Date, a mutual release that is mutually agreeable (provided, however, that
Executive shall not be required to execute such mutual release as a condition to the receipt of the payments and benefits described below unless the Company also executes such mutual release), (x) except as provided in subsection 12(d), in the
event (i) Executive’s employment is terminated by the Company for any reason other than Cause, (ii) Executive terminates his employment for Good Reason, or (iii) Executive’s employment is terminated upon the expiration of
the Term, or (y) in the event that Executive’s employment is terminated due to his death or Disability, then the Company shall: 

  

	 	(1)	pay Executive a severance amount equal to$1,065,900; the severance amount shall be paid in a single sum on the first regular payroll day of the month following the Termination Date; 

 

	 	(2)	pay to Executive, for the period ending on the earliest of (i) the first anniversary of the Termination Date, (ii) the date of Executive’s full-time employment by another employer,
(iii) Executive’s death, or (iv) the first month in which Executive does not pay to the Company the applicable monthly premium for COBRA insurance coverage under the Company’s group health plan, a monthly cash payment, payable on
the first business day of each month that follows the Termination Date, in an amount equal to the aggregate monthly premium cost for “COBRA” family health coverage under the Company’s group health plan; and 

  
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	 	(3)	pay to Executive, for the period ending on the earliest of (i) the first anniversary of the Termination Date, (ii) the date of Executive’s full-time employment by another employer, or
(iii) Executive’s death, a monthly cash payment, payable on the first business day of each month that follows the Termination Date, in an amount equal to the monthly premium cost that the Company would have paid on behalf of Executive to
cover Executive under the Company’s life and disability insurance plans if Executive’s employment with the Company had not terminated. 

  

	 	(c)	Qualifying Termination (Following Entry into Definitive Agreement but Prior to a Change in Control). In the event that (i) prior to the termination of Executive’s employment, the Company enters into a
Definitive Agreement with respect to a Change in Control that constitutes a “change in control event,” as defined in Treasury Regulation Section 1.409A-3(i)(5), (ii) following the Company’s entry into such Definitive
Agreement but prior to or on the consummation of such Change in Control, Executive terminates his employment for Good Reason, Executive’s employment is terminated by the Company for a reason other than death, Disability or Cause, or
Executive’s employment is terminated upon the expiration of the Term, and (iii) a Change in Control occurs within twelve months following the date of such Definitive Agreement, then, in addition to the amounts set forth in
Section 12(b) above, the Company shall pay Executive an amount equal to 1.99 times the amount that results from adding Executive’s Base Salary (determined without regard to any reduction in violation of Section 5) as of his last day
of active employment plus the target bonus under Section 6 (without pro ration), payable in a single sum upon the Change in Control. 

  

	 	(d)	Qualifying Termination (Following a Change in Control). Notwithstanding anything to the contrary set forth in subsection 12(b), and subject to Executive and the Company executing, within 30 days after the
Termination Date, a mutual release that is mutually agreeable (provided, however, that Executive shall not be required to execute such mutual release as a condition to the receipt of the payments and benefits described below unless the Company also
executes such mutual release), in the event within twelve months after a Change in Control: (i) Executive terminates his employment for Good Reason, or (ii) Executive’s employment is terminated by the Company for a reason other than
death, Disability or Cause, or (iii) Executive’s employment is terminated upon the expiration of the Term, then the Company shall: 

  

	 	(1)	pay Executive a severance amount equal to 2.99 times the amount that results from adding Executive’s Base Salary (determined without regard to any reduction in violation of Section 5) as of his last day of
active employment plus the target bonus under Section 6 (without pro ration); the severance amount shall be paid in a single sum on the first business day of the month following the Termination Date; 

  
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	 	(2)	pay to Executive, for the period ending on the earliest of (i) December 19 of the year following the year in which the Termination Date occurs, or (ii) Executive’s death, or (iii) the earlier of
(A) during the COBRA continuation period, the first month in which Executive does not pay to the Company the applicable monthly premium for COBRA insurance coverage under the Company’s group health plan, or (B) following the
expiration of the COBRA continuation period, the first month in which Executive does not provide the Company with evidence that he is receiving health insurance coverage from another insurance provider, a monthly cash payment, payable on the first
business day of each month that follows the Termination Date, in an amount equal to the aggregate monthly premium cost for “COBRA” family health coverage under the Company’s group health plan; 

 

	 	(3)	pay to Executive, for the period ending on the earliest of (i) December 19 of the year following the year in which the Termination Date occurs, or (ii) Executive’s death, a monthly cash payment,
payable on the first business day of each month that follows the Termination Date, in an amount equal to the monthly premium cost that the Company would have paid on behalf of Executive to cover Executive under the Company’s life and disability
insurance plans if Executive’s employment with the Company had not terminated; and 

  

	 	(4)	pay to Executive all reasonable legal fees and expenses incurred by Executive during his lifetime as a result of such termination of employment (including all fees and expenses, if any, incurred by Executive in
contesting or disputing any such termination or in seeking to obtain to enforce any right or benefit provided to Executive by this Agreement whether by arbitration or otherwise). The foregoing limitation shall not preclude Executive’s estate or
heirs from recovering reasonable legal fees (and related expenses) in accordance with the provisions hereof in the event that Executive’s estate or heirs initiate or continue any dispute or controversy arising under or in connection with this
Agreement after Executive’s death; provided, however, that such reasonable legal fees (and related expenses) are incurred within the six (6)-year period following the date of Executive’s death. The reimbursement shall be made within ninety
(90) days following the resolution of such contest or dispute (whether or not appealed), but not later than the end of the calendar year following the year in which the contest or dispute is resolved, to the extent the Company receives
reasonable written evidence of such fees and expenses. 

  
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	 	(e)	Termination Notice. Except in the event of Executive’s death, a termination under this Agreement shall be effected by means of a Termination Notice. 

 

	 	(f)	Payment Delay. Notwithstanding any provision to the contrary herein, if at the time of Executive’s termination of employment the Company’s stock is publicly traded and Executive is a “specified
employee” (as such term is defined in section 409A(2)(B)(i) of the Code and its corresponding regulations), then all cash payments to Executive pursuant to this Section 12 that are deemed as deferred compensation subject to the
requirements of section 409A of the Code shall not be paid to Executive until as soon as administratively practicable following the expiration of the six month period following the date of Executive’s Termination Date, but not later than the
first Company payroll date that occurs after the end of such six month period. Any postponed amounts shall be paid to Executive in a lump sum within thirty (30) days after the date that is six (6) months following Executive’s Date of
Termination, and any amounts payable to Executive after the expiration of such six (6) month period under this Agreement shall continue to be paid to Executive in accordance with the terms of this Agreement. If Executive dies during such
six-month period and prior to the payment of the postponed cash amounts hereunder, the amounts withheld on account of section 409A of the Code shall be paid to the personal representative of Executive’s estate within thirty (30) days after
the date of Executive’s death. If any of the cash payments payable pursuant to this Section 12 are deferred due to such requirements, there shall be added to such payments interest during the deferral period at a rate, per annum, equal to
the applicable federal short-term deferral rate (compounded monthly) in effect under section 1274(d) of the Code on Executive’s Termination Date. 

  

	 	(g)	Transfer of Mobile Phone Number. Upon the termination of Executive’s employment, the Company will release Executive’s mobile phone number and shall cooperate in transferring such phone number to a
mobile phone and service designated by Executive. 

 13. Withholding. The Company shall have the right to withhold from
all payments made pursuant to this Agreement any federal, state, or local taxes and such other amounts as may be required by law to be withheld from such payments. 

14. Assignability. The Company may assign this Agreement and its rights and obligations hereunder in whole, but not in part, to any
entity to which the Company may transfer all or substantially all of its assets, if in any such case said entity shall expressly in writing assume all obligations of the Company hereunder as fully as if it had been originally made a party hereto.
The Company may not otherwise assign this Agreement or its rights and obligations hereunder. This Agreement is personal to Executive and his rights and duties hereunder shall not be assigned except as expressly agreed to in writing by the Company.

  
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 15. Death of Executive. Any amounts due Executive under this Agreement (not including any
Base Salary not yet earned by Executive) unpaid as of the date of Executive’s death shall be paid to Executive’s surviving spouse, or if none, to the duly appointed personal representative of his estate. 

16. Restrictive Covenants. 
  

	 	(a)	Covenant Not to Compete. During the term of this Agreement and for a period of one year following the Termination Date of Executive’s employment, Executive shall not, without the express written consent of
the Company, directly or indirectly: (I) engage, anywhere within the geographical areas in which the Company is conducting business operations or providing services as of the date of Executive’s termination of employment, in the tissue
engineering business (the use of implantable absorbable materials, with or without a bioactive component, to attempt to elicit a specific cellular response in order to regenerate tissue or to impede the growth of tissue or migration of cells) (the
“Tissue Engineering Business”), neurosurgery business (the use of surgical instruments, implants, monitoring products or disposable products to treat the brain or central nervous system) (“Neurosurgery Business”), instrument
business (general surgical handheld instruments used for general purposes in surgical procedures) (“Instrument Business”), reconstruction business (bone fixation devices for foot and ankle reconstruction procedures) (“Reconstruction
Business”) or in any other line of business the revenues of which constituted at least 50% of the Company’s revenues during the six (6) month period prior to the Termination Date (together with the Tissue Engineering Business,
Neurosurgery Business, Instrument Business and Reconstruction Business, the “Business”); (II) be or become a stockholder, partner, owner, officer, director or employee or agent of, or a consultant to or give financial or other assistance
to, any person or entity engaged in the Business; (III) seek in competition with the Business to procure orders from or do business with any customer of the Company; (IV) solicit, or contact with a view to the engagement or employment by any person
or entity of, any person who is an employee of the Company; (V) seek to contract with or engage (in such a way as to adversely affect or interfere with the business of the Company) any person or entity who has been contracted with or engaged to
manufacture, assemble, supply or deliver products, goods, materials or services to the Company; or (VI) engage in or participate in any effort or act to induce any of the customers, associates, consultants, or employees of the Company to take any
action which might be disadvantageous to the Company; provided, however, that nothing herein shall prohibit Executive and his affiliates from owning, as passive investors, in the aggregate not more than 5% of the outstanding publicly traded stock of
any corporation so engaged and provided, further, however, that nothing set forth in this Section 16(a) shall prohibit Executive from becoming an employee or agent of, or consultant to, any entity that is engaged in the Business so long as
Executive does not engage in any activities in the Business in any capacity for said entity. 

  
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	 	(b)	Confidentiality. Executive acknowledges a duty of confidentiality owed to the Company and shall not, at any time during or after his employment by the Company, retain in writing, use, divulge, furnish, or make
accessible to anyone, without the express authorization of the Board, any trade secret, private or confidential information or knowledge of the Company obtained or acquired by him while so employed. All computer software, business cards, telephone
lists, customer lists, price lists, contract forms, catalogs, the Company books, records, files and know-how acquired while an employee of the Company are acknowledged to be the property of the Company and shall not be duplicated, removed from the
Company’s possession or premises or made use of other than in pursuit of the Company’s business or as may otherwise be required by law or any legal process, or as is necessary in connection with any adversarial proceeding against the
Company and, upon termination of employment for any reason, Executive shall deliver to the Company all copies thereof which are then in his possession or under his control. No information shall be treated as “confidential information” if
it is generally available public knowledge at the time of disclosure or use by Executive. 

  

	 	(c)	Inventions and Improvements. Executive shall promptly communicate to the Company all ideas, discoveries and inventions which are or may be useful to the Company or its business. Executive acknowledges that all
such ideas, discoveries, inventions, and improvements which heretofore have been or are hereafter made, conceived, or reduced to practice by him at any time during his employment with the Company heretofore or hereafter gained by him at any time
during his employment with the Company are the property of the Company, and Executive hereby irrevocably assigns all such ideas, discoveries, inventions and improvements to the Company for its sole use and benefit, without additional compensation.
The provisions of this Section 16(c) shall apply whether such ideas, discoveries, inventions, or improvements were or are conceived, made or gained by him alone or with others, whether during or after usual working hours, whether on or off the
job, whether applicable to matters directly or indirectly related to the Company’s business interests (including potential business interests), and whether or not within the specific realm of his duties. Executive shall, upon request of the
Company, but at no expense to Executive, at any time during or after his employment with the Company, sign all instruments and documents reasonably requested by the Company and otherwise cooperate with the Company to protect its right to such ideas,
discoveries, inventions, or improvements including applying for, obtaining and enforcing patents and copyrights thereon in such countries as the Company shall determine. 

  
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	 	(d)	Breach of Covenant. Executive expressly acknowledges that damages alone will be an inadequate remedy for any breach or violation of any of the provisions of this Section 16 and that the Company, in addition
to all other remedies, shall be entitled as a matter of right to equitable relief, including injunctions and specific performance, in any court of competent jurisdiction. If any of the provisions of this Section 16 are held to be in any respect
unenforceable, then they shall be deemed to extend only over the maximum period of time, geographic area, or range of activities as to which they may be enforceable. 

17. Miscellaneous. 
  

	 	(a)	Amendment. No provision of this Agreement may be amended unless such amendment is signed by Executive and such officer as may be specifically designated by the Board to sign on the Company’s behalf.

  

	 	(b)	Section 409A. 

  

	 	(1)	This Agreement shall be interpreted to avoid any penalty sanctions under section 409A of the Code. If any payment or benefit cannot be provided or made at the time specified herein without incurring sanctions under
section 409A, then such benefit or payment shall be provided in full at the earliest time thereafter when such sanctions will not be imposed. All payments to be made upon a termination of employment under this Agreement may only be made upon a
“separation from service” under section 409A of the Code. For purposes of section 409A of the Code, each payment made under this Agreement shall be treated as a separate payment. In no event may Executive, directly or indirectly, designate
the calendar year of payment. 

  

	 	(2)	All reimbursements provided under this Agreement shall be made or provided in accordance with the requirements of section 409A, including, where applicable, the requirement that (i) any reimbursement is for
expenses incurred during Executive’s lifetime (or during a shorter period of time specified in this Agreement), (ii) the amount of expenses eligible for reimbursement during a calendar year may not affect the expenses eligible for
reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or before the last day of the calendar year following the year in which the expense is incurred, and (iv) the right to reimbursement
is not subject to liquidation or exchange for another benefit. If expenses are incurred in connection with litigation, any reimbursements under the Agreement shall be paid not later than the end of the calendar year following the year in which the
litigation is resolved. 

  
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	 	(c)	Nature of Obligations. Nothing contained herein shall create or require the Company to create a trust of any kind to fund any benefits which may be payable hereunder, and to the extent that Executive acquires a
right to receive benefits from the Company hereunder, such right shall be no greater than the right of any unsecured general creditor of the Company. 

  

	 	(d)	Executive Representations and Acknowledgements. 

  

	 	(1)	Executive represents and warrants that his acceptance of employment with the Company has not breached, and the performance of his duties hereunder will not breach, any duty owed by him to any prior employer or other
person. 

  

	 	(2)	Executive acknowledges that Executive has consulted with or has had the opportunity to consult with independent counsel of his own choice concerning this Agreement and have been advised to do so by the Company. Without
limiting the generality of the foregoing, Executive acknowledges that he has had the opportunity to consult with his own independent legal counsel to review this Agreement for purposes of compliance with the requirements of section 409A of the Code
or an exemption therefrom, and that he is relying solely on the advice of his independent legal counsel for such purposes. 

  

	 	(e)	Headings. The Section headings contained in this Agreement are for reference purposes only and shall not affect in any way the meaning or interpretation or this Agreement. In the event of a conflict between a
heading and the content of a Section, the content of the Section shall control. 

  

	 	(f)	Gender and Number. Whenever used in this Agreement, a masculine pronoun is deemed to include the feminine and a neuter pronoun is deemed to include both the masculine and the feminine, unless the context clearly
indicates otherwise. The singular form, whenever used herein, shall mean or include the plural form where applicable. 

  

	 	(g)	Severability. If any provision of this Agreement or the application thereof to any person or circumstance shall be invalid or unenforceable under any applicable law, such event shall not affect or render invalid
or unenforceable any other provision of this Agreement and shall not affect the application of any provision to other persons or circumstances. 

  

	 	(h)	Binding Effect. This Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective successors, permitted assigns, heirs, executors and administrators. 

  
 14 

	 	(i)	Notice. For purposes of this Agreement, notices and all other communications provided for in this Agreement shall be in writing and shall be deemed to have been duly given if hand-delivered, sent by documented
overnight delivery service or by certified or registered mail, return receipt requested, postage prepaid, addressed to the respective addresses set forth below: 

To the Company: 

Integra LifeSciences Holdings Corporation 

311 Enterprise Drive 

Plainsboro, New Jersey 08536 

Attn: President 

With a copy to: 

The Company’s General Counsel 

To Executive: 

John B. Henneman, III 

c/o Integra LifeSciences Holdings Corporation 

311 Enterprise Drive 

Plainsboro, New Jersey 08536 
  

	 	(j)	Entire Agreement. As of the Amended Effective Date, this Agreement sets forth the entire understanding of the parties and supersedes all prior agreements, arrangements and communications, whether oral or written,
pertaining to the subject matter hereof, including the Original Agreement. 

  

	 	(k)	Governing Law. The validity, interpretation, construction and performance of this Agreement shall be governed by the laws of the United States where applicable and otherwise by the laws of the State of New
Jersey. 

  
 15 

 IN WITNESS WHEREOF, this Agreement has been executed as of the date first above written. 

 

							
	INTEGRA LIFESCIENCES HOLDINGS CORPORATION	  		  	EXECUTIVE
				
	By:	  	 /s/ Peter Arduini
	  		  	 /s/ John B. Henneman, III

	Name: Peter Arduini	  		  	John B. Henneman, III
			
	Its: President and Chief Executive OfficerEX-10.1

 Exhibit 10.1 

EMPLOYMENT AGREEMENT 

This EMPLOYMENT AGREEMENT (this “Agreement”), dated May 19, 2014 and effective as of the Commencement Date (as defined
in Section 1.2), is by and between REGADO BIOSCIENCES, INC., a Delaware corporation (the “Company”) and Nicholas J. Pelliccione, Ph.D. (the “Executive”). 

W I T N E S S E T H: 

WHEREAS, the Company desires to employ the Executive as its Senior Vice-President, Regulatory Affairs and Quality Assurance and the
Executive desires to accept such employment, on the terms and conditions set forth in this Agreement; and 
 NOW, THEREFORE,
in consideration of the promises and the mutual covenants and agreements contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound
hereby, agree as follows: 
 ARTICLE 1 

EMPLOYMENT; TERM OF AGREEMENT 

Section 1.1. Employment and Acceptance. During the Term (as defined in Section 1.2), the Company shall employ the
Executive, and the Executive shall accept such employment and continue to serve the Company, in each case, subject to the terms and conditions of this Agreement. 

Section 1.2. Term. The employment relationship hereunder shall be for the period (such period of the employment relationship shall
be referred to herein as the “Term”) commencing on May 19, 2014 (the “Commencement Date”) and ending upon the termination of this Agreement and the Executive’s employment hereunder by either party hereto
pursuant to the terms of Section 4.1, Section 4.2, Section 4.3 or Section 4.4. In the event that the Executive’s employment with the Company terminates, the Company’s obligation to continue
to pay, after the Termination Date (as defined in Section 4.2(b)), Base Salary (as defined in Section 3.1(a)), Annual Bonus (as defined in Section 3.1(b)) and other unaccrued benefits shall terminate, except as
may be provided for in ARTICLE 4. 
 ARTICLE 2 

TITLE; DUTIES AND OBLIGATIONS; LOCATION 

Section 2.1. Title. The Company shall employ the Executive to render exclusive and full-time services to the Company. The
Executive shall serve in the capacity of Senior Vice-President, Regulatory Affairs and Quality Assurance. 
 Section 2.2. Duties. The
Executive shall report to the Company’s Chief Executive Officer (the “CEO”) and be subject to the lawful direction of the Company’s Board of Directors (the “Board”) and/or the CEO. The Executive agrees to
perform to the best of his ability, experience and talent those acts and duties, consistent with the position of Senior Vice-President, Regulatory Affairs and Quality Assurance, as the Board and/or the CEO shall from time to time

  
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direct. During the Term, the Executive also shall serve in such other executive-level positions or capacities as may, from time to time, be reasonably requested by the Board and/or the CEO,
including, without limitation (subject to election, appointment, re-election or re-appointment, as applicable) as (a) a member of the Board and/or as a member of the board of directors or similar governing body of any of the Company’s
subsidiaries or other Affiliates (as defined below), (b) an officer of any of the Company’s subsidiaries or other Affiliates, and/or (c) a member of any committee of the Company and/or any of its subsidiaries or other Affiliates, in
each case, for no additional compensation. As used in this Agreement, “Affiliate” of any individual or entity means any other individual or entity that directly or indirectly controls, is controlled by, or is under common control
with, the individual or entity. 
 Section 2.3. Compliance with Policies, etc. During the Term, the Executive shall be bound by,
and comply fully with, all of the Company’s policies and procedures for employees and officers in place from time to time, including, but not limited to, all terms and conditions set forth in the Company’s employee handbook, compliance
manual, codes of conduct and any other memoranda and communications applicable to the Executive and that have been provided to the Executive pertaining to the policies, procedures, rules and regulations, as currently in effect and as may be amended
from time to time. These policies and procedures include, among other things and without limitation, the Executive’s obligations to comply with the Company’s rules regarding confidential and proprietary information and trade secrets. 

Section 2.4. Time Commitment. During the Term, the Executive shall use his best efforts to promote the interests of the Company
(including its subsidiaries and other Affiliates) and shall devote all of his business time, ability and attention to the performance of his duties for the Company and shall not, directly or indirectly, render any services to any other person or
organization, whether for compensation or otherwise, except with the CEO’s prior written consent, provided that the foregoing shall not prevent the Executive from (i) participating in charitable, civic, educational, professional, community
or industry affairs, (ii) managing the Executive’s passive personal investments, or (iii) with prior notice to the CEO, serving on the boards of directors (or similar governing bodies) and/or advisory boards of not more than two
companies, so long as such activities individually or in the aggregate do not materially interfere or conflict with the Executive’s duties hereunder or create a potential business or fiduciary conflict (in each case, as determined by the Board)
and as approved by the CEO. 
 Section 2.5. Location. The Executive’s principal place of business for the performance of
his duties under this Agreement shall be at the principal executive office of the Company (currently located in Basking Ridge, New Jersey). Notwithstanding, the foregoing, the Executive shall be required to travel as necessary to perform his duties
hereunder. 
 ARTICLE 3  

COMPENSATION AND BENEFITS; EXPENSES 

Section 3.1. Compensation and Benefits. For all services rendered by the Executive in any capacity during the Term (including,
without limitation, serving as an officer, director or member of any committee of the Company or any of its subsidiaries or other Affiliates), the Executive shall be compensated as follows (subject, in each case, to the provisions of ARTICLE
4 below): 
 (a) Base Salary. During the Term, the Company shall pay the Executive a base salary (the “Base
Salary”) at the annualized rate of $275,000, which shall be subject to customary withholdings and authorized deductions and be payable in equal installments in accordance with the Company’s customary payroll practices in place from
time to time. The Executive’s Base salary shall be subject to periodic adjustments as the Board and/or the Compensation Committee of the Board (the “Compensation Committee”) shall in its/their discretion deem appropriate. As
used in this Agreement, the term “Base Salary” shall refer to Base Salary as may be adjusted from time to time. 

  
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 (b) Annual Bonus. For each calendar year ending during the Term (beginning with the
calendar year ending December 31, 2014), the Executive shall be eligible to receive an annual bonus (the “Annual Bonus”) with a target amount equal to thirty-five percent (35%) of the Base Salary earned by the Executive
for such calendar year (the “Target Annual Bonus”). The Annual Bonus will be prorated for the current year (2014) according to the number of months remaining in the year, following the Commencement Date, and based on the
Executive’s length of employment during such year. The actual amount of each Annual Bonus will be based upon the level of achievement of the Company’s corporate objectives and the Executive’s individual objectives, in each case, as
established by the Board or the Compensation Committee (taking into account the input of the CEO with respect to the establishment of the Executive’s individual objectives) for the calendar year with respect to which such Annual Bonus relates.
The determination of the level of achievement of the corporate objectives and the Executive’s individual performance objectives for a year shall be made by the Board or the Compensation Committee (taking into account the input of the CEO with
respect to the level of achievement of the Executive’s individual objectives), in its reasonable discretion. Each Annual Bonus for a calendar year, to the extent earned, will be paid in a lump sum in the following calendar year, within the
first 75 days of such following year. Except as otherwise provided in this Agreement, the Annual Bonus shall not be deemed earned until the date that it is paid. Accordingly, except as otherwise provided in this Agreement, in order for the Executive
to receive an Annual Bonus, the Executive must be actively employed by the Company at the time of such payment. No partial or prorated bonuses will be provided (other than for 2014, if at all, as stated above). 

(c) Equity Compensation. 

(i) Initial Option Grant. Subject to formal approval by the Compensation Committee of the Board, and as a material inducement to the
Executive’s employment, at the next meeting of the Compensation Committee held on or following the Commencement Date, the Executive will be granted options (the “Initial Option Grant”) to purchase up to 100,000 shares of the
Company’s common stock (at a per share exercise price equal to fair market value per share of the Company’s common stock as of the date of grant). The Initial Option Grant shall be subject to the terms and conditions established within any
plan that may be adopted by the Company providing for the issuance of inducement awards pursuant to NASDAQ Listing Rule 5635(c)(4) or any successor equity compensation plan as may be in place from time to time (the “Inducement
Plan”) and the separate stock option agreement between the Company and the Executive (the “Initial Stock Option Agreement”). The Initial Stock Option Agreement will provide that, among other things: (A) 25,000 of such
shares shall vest on the one (1) year anniversary of the date of the Initial Option Grant (the “Initial Vesting Date”), and (B) the remaining shares shall vest ratably in equal monthly installments over the following three
(3)

  
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year period, commencing with the one (1) month anniversary of the Initial Vesting Date and continuing on the same day of each calendar month thereafter through and including the thirty-six
(36) month anniversary of the Initial Vesting Date, in each case, subject to the Executive’s continued employment with the Company on the applicable vesting date. 

(ii) The Executive also shall be eligible to receive from time to time additional Stock Options, Stock Units, Performance Shares, Performance
Units, Incentive Bonus Awards, Other Cash-Based Awards and/or Other Stock-Based Awards (as such capitalized terms are defined in the Company’s 2013 Equity Compensation Plan), in amounts, if any, to be approved by the Board or the Compensation
Committee in its discretion. 
 (d) Benefit Plans. The Executive shall be entitled to participate in all employee benefit plans and
programs (excluding severance plans, if any) generally made available by the Company to senior executives of the Company, to the extent permissible under the general terms and provisions of such plans or programs and in accordance with the
provisions thereof. The Company may amend, modify or rescind any employee benefit plan or program and/or change employee contribution amounts to benefit costs without notice in its discretion. 

(e) Paid Vacation. The Executive shall be entitled to paid vacation days in accordance with the Company’s vacation policies in
effect from time to time for its executive team; provided, however, that Executive shall be entitled to no less than twenty (20) paid vacation days per calendar year during the Term. 

ARTICLE 4  
 TERMINATION
OF EMPLOYMENT 
 Section 4.1. Termination Without Cause. 

(a) The Company may terminate the Executive’s employment hereunder at any time without Cause (other than by reason of death or
Disability) upon written notice to the Executive. 
 (b) As used in this Agreement, “Cause” means: (i) a material act,
or act of fraud, committed by the Executive that results in a material injury (whether financial or otherwise) to the business or reputation of the Company or any of its Affiliates; (ii) the Executive’s commission of a felony or any
misdemeanor involving moral turpitude, deceit, dishonesty or fraud (including entry of a nolo contendere plea); (iii) gross negligence or willful misconduct by the Executive, or failure by the Executive to perform the duties or
obligations reasonably assigned to the Executive by the Board or the CEO from time to time, which is not cured upon ten (10) days prior written notice (unless such negligence, misconduct or failure is not susceptible to cure, as determined in
the reasonable discretion of the Board); (iv) the Executive’s breach of this Agreement, the Covenants Agreement (as defined in Section 5.1 below) or any Company policy, which is not cured upon ten (10) days prior written
notice (unless such breach is not susceptible to cure, as determined in the reasonable discretion of the Board); or (v) the Executive’s misappropriation or embezzlement of the property of the Company or its Affiliates (whether or not a
misdemeanor or felony). 

  
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 (c) If the Executive’s employment is terminated pursuant to Section 4.1(a), the
Executive shall, in full discharge of all of the Company’s obligations to the Executive, be entitled to receive, and the Company’s sole obligation to the Executive under this Agreement or otherwise shall be to pay or provide to the
Executive, the following: 
 (i) the Accrued Obligations (as defined in Section 4.2(b)); and 

(ii) subject to Section 4.5 and Section 4.6: 

(A) payments equal to the sum of twelve (12) months of the Executive’s Base Salary (at the rate in effect immediately
prior to the Termination Date) and the Executive’s Target Bonus for the calendar year in which the Termination Date occurs (in each case, less applicable withholdings and authorized deductions), to be paid semi-monthly in accordance with the
Company’s customary payroll practices, commencing sixty (60) days following such termination of employment (the “Severance Payments”) until the full amount due under this clause (A) has been fully paid; and 

(B) if the Executive then participates in the Company’s medical and/or dental plans and the Executive timely elects to
continue and maintain group health plan coverage pursuant to the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”), the Company will pay monthly, on the Executive’s behalf, a portion of the cost of
such coverage for the twelve (12) months after the Termination Date, which payments will be equal to the amount of the monthly premium for such coverage, less the amount that the Executive would have been required to pay if the Executive had
remained an active employee of the Company (the “COBRA Assistance”); provided, however, that if and to the extent that the Company may not provide such COBRA Assistance without incurring tax penalties or violating any
requirement of the law, the Company shall use its commercially reasonable best efforts to provide substantially similar assistance in an alternative manner provided that the cost of doing so does not exceed the cost that the Company would have
incurred had the COBRA Assistance been provided in the manner described above or cause a violation of Section 409A (as defined in Section 5.16). 

Section 4.2. Termination for Cause; Voluntary Termination. 

(a) The Company may terminate the Executive’s employment hereunder at any time for Cause upon written notice to the Executive. The
Executive may voluntarily terminate his employment hereunder at any time for any reason or no reason upon ninety (90) days prior written notice to the Company; provided, however, the Company reserves the right, upon written notice
to the Executive, to accept the Executive’s notice of resignation and to accelerate such notice and make the Executive’s resignation effective immediately, or on such other date prior to Executive’s intended last day of work as the
Company deems appropriate. It is understood and agreed that the Company’s election to accelerate Executive’s notice of resignation shall not be deemed a termination by the Company without Cause for purposes of Section 4.1 of
this Agreement or otherwise or constitute Good Reason (as defined in Section 4.3) for purposes of Section 4.3 of this Agreement or otherwise. 

  
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 (b) If the Executive’s employment is terminated pursuant to Section 4.2(a), the
Executive shall, in full discharge of all of the Company’s obligations to the Executive, be entitled to receive, and the Company’s sole obligation under this Agreement or otherwise shall be to pay or provide to the Executive, the following
(collectively, the “Accrued Obligations”): 
 (i) the Executive’s earned, but unpaid, Base Salary
through the final date of the Executive’s employment by the Company (the “Termination Date”), payable in accordance with the Company’s standard payroll practices; 

(ii) the Executive’s Annual Bonus for the prior calendar year, if and to the extent that (A) the Termination Date is
after the 75th day of the calendar year and (B) such Annual Bonus had not been paid to the Executive on or prior to the 75th day of the
calendar year in which the Termination Date occurs; 
 (iii) the Executive’s accrued, but unused, vacation (in
accordance with the Company’s policies); 
 (iv) expenses reimbursable under Section 3.2 above incurred on
or prior to the Termination Date, but not yet reimbursed; and 
 (v) any amounts or benefits that are vested amounts or
vested benefits or that the Executive is otherwise entitled to receive under any plan, program, policy or practice (with the exception of those, if any, relating to severance) on the Termination Date, in accordance with such plan, program, policy,
or practice. 
  

	 	Section 4.3.	Termination for Good Reason within 12 Months following a Change in Control. 

 (a)
Notwithstanding the provisions of Section 4.2, if the Executive resigns for Good Reason within twelve (12) months following a Change in Control of the Company, the provisions of this Section 4.3 shall control. 

(b) As used in this Agreement, “Change in Control” means (x) a change in ownership of the Company under clause
(i) below or (y) a change in the ownership of a substantial portion of the assets of the Company under clause (ii) below: 

(i) Change in the Ownership of the Company. A change in the ownership of the Company shall occur on the date that any
one person, or more than one person acting as a group (as defined in clause (iii) below), acquires ownership of capital stock of the Company that, together with capital stock held by such person or group, constitutes more than 50 percent of the
total fair market value or total voting power of the capital stock of the Company. However, if any one person or more than one person acting as a group, is considered to own more than 50 percent of the total fair market value or total voting power
of the capital stock of the Company, the acquisition of additional capital stock by the same person or persons shall not be considered to be a change in the ownership of the Company. An increase in the percentage of capital stock owned by any one
person, or persons acting as a group, as a result of a transaction in which the Company acquires capital stock in the Company in exchange for property will be treated as an acquisition of stock for purposes of this paragraph. 

  
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 (ii) Change in the Ownership of a Substantial Portion of the Company’s
Assets. A change in the ownership of a substantial portion of the Company’s assets shall occur on the date that any one person, or more than one person acting as a group (as defined in clause (iii) below), acquires (or has acquired
during the 12-month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value equal to or more than 80 percent of the total gross fair market value of all of
the assets of the Company immediately prior to such acquisition or acquisitions. For this purpose, gross fair market value means the value of the assets of the Company, or the value of the assets being disposed of, determined without regard to any
liabilities associated with such assets. There is no Change in Control under this clause (ii) when there is a transfer to an entity that is controlled by the shareholders of the Company immediately after the transfer, as provided below in this
clause (ii). A transfer of assets by the Company is not treated as a change in the ownership of such assets if the assets are transferred to (a) a shareholder of the Company (immediately before the asset transfer) in exchange for or with
respect to its capital stock, (b) an entity, 50 percent or more of the total value or voting power of which is owned, directly or indirectly, by the Company, (c) a person, or more than one person acting as a group, that owns, directly or
indirectly, 50 percent or more of the total value or voting power of all the outstanding capital stock of the Company, or (d) an entity, at least 50 percent of the total value or voting power of which is owned, directly or indirectly, by a
person described in clause (ii)(c) of this paragraph. For purposes of this clause (ii), a person’s status is determined immediately after the transfer of the assets. 

(iii) Persons Acting as a Group. For purposes of clauses (i) and (ii) above, persons will not be considered
to be acting as a group solely because they purchase or own capital stock or purchase assets of the Company at the same time. However, persons will be considered to be acting as a group if they are owners of a corporation that enters into a merger,
consolidation, purchase or acquisition of assets or capital stock, or similar business transaction with the Company. If a person, including an entity, owns stock in both corporations that enter into a merger, consolidation, purchase or acquisition
of assets or capital stock, or similar transaction, such shareholder is considered to be acting as a group with other shareholders in a corporation only with respect to the ownership in that corporation before the transaction giving rise to the
change and not with respect to the ownership interest in the other corporation. For purposes of this paragraph, the term “corporation” shall have the meaning assigned such term under Treasury Regulation section 1.280G-1, Q&A-45. 

(iv) Each of clauses (i) through (iii) above shall be construed and interpreted consistent with the requirements of
Section 409A and any Treasury Regulations or other guidance issued thereunder. 

  
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 (c) As used in this Agreement, “Good Reason” means the occurrence of any of the
following: (1) a material breach by the Company of the terms of this Agreement; (2) a material reduction in the Executive’s Base Salary; (3) a material diminution in the Executive’s authority, duties or responsibilities; or
(4) a relocation by the Company of the Executive’s principal place of business for the performance of his duties under this Agreement to a location that is anywhere outside of a 50 mile radius of Basking Ridge, New Jersey; provided,
however, that the Executive must notify the Company within ninety (90) days of the occurrence of any of the foregoing conditions that he considers it to be a “Good Reason” condition and provide the Company with at least thirty
(30) days in which to cure the condition. If the Executive fails to provide this notice and cure period prior to his resignation, or resigns more than six (6) months after the initial existence of the condition, his resignation will not be
deemed to be for “Good Reason.” 
 (d) If the Executive’s employment terminates pursuant to Section 4.3(a)
(i.e., the Executive resigns for Good Reason within twelve (12) months following a Change in Control of the Company), the Executive shall, in full discharge of all of the Company’s obligations to the Executive, be entitled to
receive, and the Company’s sole obligation to the Executive under this Agreement or otherwise shall be to pay or provide to the Executive, the following: 

(i) the Accrued Obligations; and 

(ii) subject to Section 4.5 and Section 4.6: 

(a) the Severance Payments, payable in accordance with the terms of Section 4.1(c)(ii)(A); and 

(b) if the Executive then participates in the Company’s medical and/or dental plans and the Executive timely elects to continue and
maintain group health plan coverage pursuant to COBRA, the Company will provide the COBRA Assistance, which COBRA Assistance will be payable in accordance with, and subject to the terms set forth in, Section 4.1(c)(ii)(B). 

Section 4.4. Termination Resulting from Death or Disability. 

(a) As the result of any Disability suffered by the Executive, the Company may, upon five (5) days prior notice to the Executive,
terminate the Executive’s employment under this Agreement. The Executive’s employment shall automatically terminate upon his death. 

(b) “Disability” means a determination by the Company in accordance with applicable law that as a result of a physical or
mental injury or illness, the Executive is unable to perform the essential functions of his job with or without reasonable accommodation for a period of (i) ninety (90) consecutive days; or (ii) one hundred twenty (120) days
during any twelve (12) month period. 
 (c) If the Executive’s employment is terminated pursuant to Section 4.4(a),
the Executive or the Executive’s estate, as the case may be, shall be entitled to receive, and the Company’s sole obligation under this Agreement or otherwise shall be to pay or provide to the Executive or the Executive’s estate, as
the case may be, the Accrued Obligations. 

  
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 Section 4.5. Release Agreement. In order to receive the Severance Payments or the
COBRA Assistance set forth in Section 4.1 or Section 4.3 (in each case, if eligible), the Executive must timely execute (and not revoke) a separation agreement and general release (the “Release Agreement”) in
a customary form as is determined to be reasonably necessary by the Company in its good faith and reasonable discretion. If the Executive is eligible for Severance Payments and COBRA Assistance pursuant to Section 4.1 or
Section 4.3, the Company will deliver the Release Agreement to the Executive within seven (7) calendar days following the Termination Date. The Severance Payments and COBRA Assistance are subject to the Executive’s execution of
such Release Agreement within 45 days of the Executive’s receipt of the Release Agreement and the Executive’s non-revocation of such Release Agreement. 

Section 4.6. Post-Termination Breach. Notwithstanding anything to the contrary contained in this Agreement, the Company’s
obligations to provide the Severance Payments and the COBRA Assistance will immediately cease if the Executive breaches any of the provisions of the Covenants Agreement, the Release Agreement or any other agreement the Executive has with the
Company, or if any provision of those agreements is determined to be unenforceable, to any extent, by a court or arbitration panel, whether by preliminary or final adjudication. 

Section 4.7. Removal from any Boards and Position. If the Executive’s employment is terminated for any reason under this
Agreement, he shall be deemed (without further action, deed or notice) to resign (i) if a member, from the Board or board of directors (or similar governing body) of any Affiliate of the Company or any other board to which he has been appointed
or nominated by or on behalf of the Company and (ii) from all other positions with the Company or any subsidiary or other Affiliate of the Company, including, but not limited to, as an officer of the Company and any of its subsidiaries or other
Affiliates. 
 ARTICLE 5  

GENERAL PROVISIONS 

Section 5.1. Company Proprietary Information, Inventions, and Noncompetition Agreement. The Executive agrees to execute and be
bound by the Proprietary Information, Inventions, and Noncompetition Agreement (“Covenants Agreement”) attached hereto as Schedule A, the terms of which are incorporated herein by reference. The Covenants Agreement shall
survive the termination of this Agreement and the Executive’s employment by the Company for the applicable period(s) set forth therein. 

Section 5.2. Expenses. Each of the Company and the Executive shall bear its/his own costs, fees and expenses in connection with
the negotiation, preparation and execution of this Agreement. 
 Section 5.3. Entire Agreement. This Agreement and the Covenants
Agreement contain the entire agreement of the parties hereto with respect to the terms and conditions of the Executive’s employment during the Term and activities following termination of this Agreement and the Executive’s employment with
the Company and supersede any and all prior agreements and understandings, whether written or oral, between the parties hereto with respect to the subject matter of this Agreement and the Covenants Agreement. Each party hereto acknowledges that no
representations, inducements, promises or agreements, whether oral or in writing, have 

  
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been made by any party, or on behalf of any party, which are not embodied herein or in the Covenants Agreement. No agreement, promise or statement not contained in this Agreement or the Covenants
Agreement shall be valid and binding, unless agreed to in writing and signed by the parties sought to be bound thereby. 
 Section 5.4.
No Other Contracts. The Executive represents and warrants to the Company that neither the execution and delivery of this Agreement by the Executive nor the performance by the Executive of the Executive’s obligations hereunder, shall
constitute a default under or a breach of the terms of any other agreement, contract or other arrangement, whether written or oral, to which the Executive is a party or by which the Executive is bound, nor shall the execution and delivery of this
Agreement by the Executive nor the performance by the Executive of his duties and obligations hereunder give rise to any claim or charge against either the Executive, the Company or any Affiliate, based upon any other contract or other arrangement,
whether written or oral, to which the Executive is a party or by which the Executive is bound. The Executive further represents and warrants to the Company that he is not a party to or subject to any restrictive covenants, legal restrictions or
other agreement, contract or arrangement, whether written or oral, in favor of any entity or person which would in any way preclude, inhibit, impair or limit the Executive’s ability to perform his obligations under this Agreement, including,
but not limited to, non-competition agreements, non-solicitation agreements or confidentiality agreements. The Executive shall defend, indemnify and hold the Company harmless from and against all claims, actions, losses, liabilities, damages, costs
and expenses (including reasonable attorney’s fees and amounts paid in settlement in good faith) arising from or relating to any breach of the representations and warranties made by the Executive in this Section 5.4. 

Section 5.5. Notices. Any notice or other communication required or permitted hereunder shall be in writing and shall be delivered
personally or sent by nationally recognized overnight courier service (with next business day delivery requested). Any such notice or communication shall be deemed given and effective, in the case of personal delivery, upon receipt by the other
party, and in the case of a courier service, upon the next business day, after dispatch of the notice or communication. Any such notice or communication shall be addressed as follows: 

If to the Company, to: 

Regado Biosciences, Inc. 

120 Mountain View Boulevard 

Basking Ridge, NJ 07920 

Attn: Board of Directors 

With a copy to: 

Cooley LLP 

500 Boylston St. 

Boston, MA 02116 

Attn: Michael N. Sheetz, Esq. 

If to the Executive, to: 

Nicholas J. Pelliccione, Ph.D. 

665 E. 17 Street 

Brooklyn, NY 11230-1703 

  
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 Any person named above may designate another address or fax number by giving notice in accordance with this
Section to the other persons named above. 
 Section 5.6. Governing Law; Jurisdiction. This Agreement shall be governed by, and
construed in accordance with, the laws of the State of New Jersey, without regard to principles of conflicts of law. Any and all actions arising out of this Agreement or Employee’s employment by Company or termination therefrom shall be brought
and heard in the state and federal courts of the State of New Jersey and the parties hereto hereby irrevocably submit to the exclusive jurisdiction of any such courts. THE COMPANY AND THE EXECUTIVE HEREBY WAIVE THEIR RESPECTIVE RIGHT TO TRIAL BY
JURY IN ANY ACTION CONCERNING THIS AGREEMENT OR ANY AND ALL MATTERS ARISING DIRECTLY OR INDIRECTLY HEREFROM AND REPRESENT THAT THEY HAVE CONSULTED WITH COUNSEL OF THEIR CHOICE OR HAVE CHOSEN VOLUNTARILY NOT TO DO SO SPECIFICALLY WITH RESPECT TO THIS
WAIVER. 
 Section 5.7. Waiver. Either party hereto may waive compliance by the other party with any provision of this
Agreement. The failure of a party to insist on strict adherence to any term of this Agreement on any occasion shall not be considered a waiver or deprive that party of the right thereafter to insist upon strict adherence to that term or any other
term of this Agreement. No waiver of any provision shall be construed as a waiver of any other provision. Any waiver must be in writing. 

Section 5.8. Severability. If any one or more of the terms, provisions, covenants and restrictions of this Agreement shall be
determined by a court of competent jurisdiction to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full force and effect and shall in no way be affected,
impaired or invalidated and the parties will attempt to agree upon a valid and enforceable provision which shall be a reasonable substitute for such invalid and unenforceable provision in light of the tenor of this Agreement, and, upon so agreeing,
shall incorporate such substitute provision in this Agreement. In addition, if any one or more of the provisions contained in this Agreement shall for any reason be determined by a court of competent jurisdiction to be excessively broad as to
duration, geographical scope, activity or subject, it shall be construed, by limiting or reducing it, so as to be enforceable to the extent compatible with then applicable law. 

Section 5.9. Counterparts. This Agreement may be executed in any number of counterparts and each such duplicate counterpart shall
constitute an original, any one of which may be introduced in evidence or used for any other purpose without the production of its duplicate counterpart. Moreover, notwithstanding that any of the parties did not execute the same counterpart, each
counterpart shall be deemed for all purposes to be an original, and all such counterparts shall constitute one and the same instrument, binding on all of the parties hereto. 

  
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 Section 5.10. Advice of Counsel. Both parties hereto acknowledge that they have had
the opportunity to seek and obtain the advice of counsel before entering into this Agreement and have done so to the extent desired, and have fully read the Agreement and understand the meaning and import of all the terms hereof. 

Section 5.11. Assignment. This Agreement shall inure to the benefit of the Company and its successors and assigns (including,
without limitation, the purchaser of all or substantially all of its assets) and shall be binding upon the Company and its successors and assigns. This Agreement is personal to the Executive, and the Executive shall not assign or delegate his rights
or duties under this Agreement, and any such assignment or delegation shall be null and void. 
 Section 5.12. Agreement to Take
Actions. Each party to this Agreement shall execute and deliver such documents, certificates, agreements and other instruments, and shall take all other actions, as may be reasonably necessary or desirable in order to perform his or its
obligations under this Agreement. 
 Section 5.13. No Attachment. Except as required by law, no right to receive payments under
this Agreement shall be subject to anticipation, commutation, alienation, sale, assignment, encumbrance, charge, pledge, or hypothecation or to execution, attachment, levy or similar process or assignment by operation of law, and any attempt,
voluntary or involuntary, to effect any such action shall be null, void and of no effect; provided, however, that nothing in this Section 5.13 shall preclude the assumption of such rights by executors, administrators or
other legal representatives of the Executive or the Executive’s estate and their assigning any rights hereunder to the person or persons entitled thereto. 

Section 5.14. Source of Payment. Except as otherwise provided under the terms of any applicable employee benefit plan, all
payments provided for under this Agreement shall be paid in cash from the general funds of Company. The Company shall not be required to establish a special or separate fund or other segregation of assets to assure such payments, and, if the Company
shall make any investments to aid it in meeting its obligations hereunder, the Executive shall have no right, title or interest whatever in or to any such investments except as may otherwise be expressly provided in a separate written instrument
relating to such investments. Nothing contained in this Agreement, and no action taken pursuant to its provisions, shall create or be construed to create a trust of any kind, or a fiduciary relationship, between Company and the Executive or any
other person. To the extent that any person acquires a right to receive payments from Company hereunder, such right, without prejudice to rights which employees may have, shall be no greater than the right of an unsecured creditor of Company. The
Executive shall not look to the owners of the Company for the satisfaction of any obligations of the Company under this Agreement. 

Section 5.15. Tax Withholding. The Company or other payor is authorized to withhold from any benefit provided or payment due
hereunder, the amount of withholding taxes due any federal, state or local authority in respect of such benefit or payment and to take such other action as may be necessary in the opinion of the Board to satisfy all obligations for the payment of
such withholding taxes. The Executive will be solely responsible for all taxes assessed against him with respect to the compensation and benefits described in this Agreement, other than typical employer-paid taxes such as FICA, and the Company makes
no representations as to the tax treatment of such compensation and benefits. 

  
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 Section 5.16. 409A Compliance. All payments under this Agreement are intended to
comply with or be exempt from the requirements of Section 409A of the Code and regulations promulgated thereunder (“Section 409A”). As used in this Agreement, the “Code” means the Internal Revenue Code of 1986,
as amended. To the extent permitted under applicable regulations and/or other guidance of general applicability issued pursuant to Section 409A, the Company reserves the right to modify this Agreement to conform with any or all relevant
provisions regarding compensation and/or benefits so that such compensation and benefits are exempt from the provisions of 409A and/or otherwise comply with such provisions so as to avoid the tax consequences set forth in Section 409A and to
assure that no payment or benefit shall be subject to an “additional tax” under Section 409A. To the extent that any provision in this Agreement is ambiguous as to its compliance with Section 409A, or to the extent any provision
in this Agreement must be modified to comply with Section 409A, such provision shall be read in such a manner so that no payment due to the Executive shall be subject to an “additional tax” within the meaning of
Section 409A(a)(1)(B) of the Code. If necessary to comply with the restriction in Section 409A(a)(2)(B) of the Code concerning payments to “specified employees,” any payment on account of the Executive’s separation from
service that would otherwise be due hereunder within six (6) months after such separation shall be delayed until the first business day of the seventh month following the Termination Date and the first such payment shall include the cumulative
amount of any payments (without interest) that would have been paid prior to such date if not for such restriction. Each payment in a series of payments hereunder shall be deemed to be a separate payment for purposes of Section 409A. In no
event may the Executive, directly or indirectly, designate the calendar year of payment. All reimbursements provided under this Agreement shall be made or provided in accordance with the requirements of Section 409A, including, where
applicable, the requirement that (i) any reimbursement is for expenses incurred during the Executive’s lifetime (or during a shorter period of time specified in this Agreement), (ii) the amount of expenses eligible for reimbursement
during a calendar year may not affect the expenses eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or before the last day of the calendar year following the year in which the
expense is incurred, and (iv) the right to reimbursement is not subject to liquidation or exchange for another benefit. Notwithstanding anything contained herein to the contrary, the Executive shall not be considered to have terminated
employment with the Company for purposes of Section 4.1 or 4.3 unless the Executive would be considered to have incurred a “termination of employment” from the Company within the meaning of Treasury Regulation
§1.409A-1(h)(1)(ii). In no event whatsoever shall the Company be liable for any additional tax, interest or penalty that may be imposed on the Executive by Section 409A or damages for failing to comply with Section 409A. 

Section 5.17. 280G Modified Cutback. 

(a) If any payment, benefit or distribution of any type to or for the benefit of the Executive, whether paid or payable, provided or to be
provided, or distributed or distributable pursuant to the terms of this Agreement or otherwise (collectively, the “Parachute Payments”) would (i) constitute a “parachute payment” within the meaning of
Section 280G of the Code, and (ii) subject the Executive to the excise tax imposed under Section 4999 of the Code (the “Excise 

  
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Tax”), the Parachute Payments shall be reduced so that the maximum amount of the Parachute Payments (after reduction) shall be one dollar ($1.00) less than the amount which would cause the
Parachute Payments to be subject to the Excise Tax; provided that the Parachute Payments shall only be reduced to the extent the after-tax value of amounts received by the Executive after application of the above reduction would exceed the after-tax
value of the amounts received without application of such reduction. For this purpose, the after-tax value of an amount shall be determined taking into account all federal, state, and local income, employment and excise taxes applicable to such
amount. Unless the Executive shall have given prior written notice to the Company to effectuate a reduction in the Parachute Payments if such a reduction is required, which notice shall be consistent with the requirements of Section 409A to
avoid the imputation of any tax, penalty or interest thereunder, then the Company shall reduce or eliminate the Parachute Payments by first reducing or eliminating any cash payments (with the payments to be made furthest in the future being reduced
first), then by reducing or eliminating accelerated vesting of stock options or similar awards, and then by reducing or eliminating any other remaining Parachute Payments; provided, that no such reduction or elimination shall apply to any
non-qualified deferred compensation amounts (within the meaning of Section 409A) to the extent such reduction or elimination would accelerate or defer the timing of such payment in manner that does not comply with Section 409A. 

(b) An initial determination as to whether (x) any of the Parachute Payments received by the Executive in connection with the occurrence
of a change in the ownership or control of the Company or in the ownership of a substantial portion of the assets of the Company shall be subject to the Excise Tax, and (y) the amount of any reduction, if any, that may be required pursuant to
the previous paragraph, shall be made by an independent accounting firm selected by the Company (the “Accounting Firm”) prior to the consummation of such change in the ownership or effective control of the Company or in the
ownership of a substantial portion of the assets of the Company. The Company will bear all expenses with respect to the determinations by such Accounting Firm required to be made hereunder. The Executive shall be furnished with notice of all
determinations made as to the Excise Tax payable with respect to the Executive’s Parachute Payments, together with the related calculations of the Accounting Firm, promptly after such determinations and calculations have been received by the
Company. 
 (c) For purposes of this Section 5.17, (i) no portion of the Parachute Payments the receipt or enjoyment of
which the Executive shall have effectively waived in writing prior to the date of payment of the Parachute Payments shall be taken into account; (ii) no portion of the Parachute Payments shall be taken into account which in the opinion of the
Accounting Firm does not constitute a “parachute payment” within the meaning of Section 280G(b)(2) of the Code; (iii) the Parachute Payments shall be reduced only to the extent necessary so that the Parachute Payments (other than
those referred to in the immediately preceding clause (i) or (ii)) in their entirety constitute reasonable compensation for services actually rendered within the meaning of Section 280G(b)(4) of the Code or are otherwise not subject to
disallowance as deductions, in the opinion of the auditor or tax counsel referred to in such clause (ii); and (iv) the value of any non-cash benefit or any deferred payment or benefit included in the Parachute Payments shall be determined by
the Company’s independent auditors based on Sections 280G and 4999 of the Code and the regulations for applying those sections of the Code, or on substantial authority within the meaning of Section 6662 of the Code. 

  
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 [Signature Page Follows] 

  
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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year
first above written. 
  

			
	COMPANY
	
	 Regado Biosciences, Inc.

		
	By:	 	 /s/ David J. Mazzo, Ph.D.

	Name:	 	David J. Mazzo, Ph.D.
	Title:	 	Chief Executive Officer
	
	EXECUTIVE
	
	 /s/ Nicholas J. Pelliccione, Ph.D.

	Nicholas J. Pelliccione, Ph.D.

 [SIGNATURE PAGE TO EMPLOYMENT
AGREEMENT] 

 SCHEDULE A 

Proprietary Information, Inventions, and Noncompetition Agreement

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