Document:

CONSENT OF LARRY LEGEL, CPA

I have issued my auditor's report dated August 29, 2000, accompanying the
financial statements of Triple A Homes, Inc. as of and for the period ended
December 31, 1999 and my accountant's review report for the six months ended
June 30, 2000 contained in the Registration Statement on Form SB-1 and
Prospectus. I consent to the use of the aforementioned reports in the
Registration Statement and Prospectus.

/s/ Larry Legel, CPA
------------------------------

Fort Lauderdale, Florida
September 20, 2000

                              Exhibit Number 10.2EXHIBIT 4.6

                      PRINCIPIA PHARMACEUTICAL CORPORATION

                          1999 EQUITY COMPENSATION PLAN

                     Amended and Restated September 8, 2000

         Principia   Pharmaceutical    Corporation,   a   Delaware   corporation
("Principia")  adopted  the  Principia  Pharmaceutical  Corporation  1999 Equity
Compensation Plan (the "Plan") to provide (i) designated  employees of Principia
and its subsidiaries (ii) certain consultants and advisors who performs services
for Principia or its subsidiaries and (iii) non-employee members of the Board of
Directors of Principia with the opportunity to receive grants of incentive stock
options, nonqualified stock options and restricted stock.

         Human Genome  Sciences,  Inc., a Delaware  corporation (the "Company"),
became  the  parent  corporation  of  Principia  pursuant  to  the  transactions
contemplated  in the  Agreement  and Plan of  Reorganization  by and  among  the
Company,  Principia,  the  stockholders  of Principia as listed in the signature
page of the Merger  Agreement,  and PCCA Inc.,  a  Delaware  corporation,  dated
September 8, 2000 (the "Merger  Agreement").  Pursuant to the Merger  Agreement,
the  Company  assumed and amended  and  restated  the Plan as set forth  herein,
effective September 8, 2000.

         1.       Administration

         (a) Committee.  The Plan shall be  administered  and interpreted by the
Board of Directors of the Company (the  "Board") or by a committee  appointed by
the Board.  After an initial public offering of the Company's stock as described
in Section  18(b) (a "Public  Offering"),  the Plan shall be  administered  by a
committee,  which may consist of "outside  directors"  as defined  under section
162(m) of the  Internal  Revenue  Code of 1986,  as amended  (the  "Code"),  and
related Treasury regulations and "non-employee  directors" as defined under Rule
16b-3 under the  Securities  Exchange  Act of 1934,  as amended  (the  "Exchange
Act").  However,  the  board  may  ratify  or  approve  any  grants  as it deems
appropriate.  If a committee administers the Plan, references in the Plan to the
"Board," as they relate to Plan administration,  shall be deemed to refer to the
committee.

         (b) Board  Authority.  The Board shall have the sole  authority  to (i)
determine  the  individuals  to whom grants  shall be made under the Plan,  (ii)
determine  the  type,  size and  terms  of the  grants  to be made to each  such
individual,  (iii)  determine  the  time  when the  grants  will be made and the
duration  of any  applicable  exercise  or  restriction  period,  including  the
criteria for exercisability  and the acceleration of exercisability,  (iv) amend
the terms of any  previously  issued grant,  and (v) deal with any other matters
arising under the Plan.

<PAGE>

         (c) Board Determinations. The Board shall have full power and authority
to administer  and interpret  the Plan,  to make factual  determinations  and to
adopt  or  amend  such  rules,  regulations,   agreements  and  instruments  for
implementing  the Plan and for the conduct of its business as it deems necessary
or advisable,  in its sole discretion.  The Board's  interpretations of the Plan
and all  determinations  made by the Board  pursuant to the powers  vested in it
hereunder  shall be conclusive and binding on all persons having any interest in
the Plan or in any awards  granted  hereunder.  All powers of the Board shall be
executed in its sole discretion,  in the best interest of the Company,  not as a
fiduciary,  and in  keeping  with  the  objectives  of the  Plan and need not be
uniform as to similarly situated individuals.

         2.       Grants

         Awards under the Plan may consist of grants of incentive  stock options
as  described  in Section 5  ("Incentive  Stock  Options"),  nonqualified  stock
options as  described in Section 5  ("Nonqualified  Stock  Options")  (Incentive
Stock Options and  Nonqualified  Stock Options are  collectively  referred to as
"Options") and restricted  stock as described in Section 6 ("Restricted  Stock")
(hereinafter  collectively referred to as "Grants"). All Grants shall be subject
to the terms  and  conditions  set  forth  herein  and to such  other  terms and
conditions  consistent with this Plan as the Board deems  appropriate and as are
specified in writing by the Board to the individual in a grant  instrument or an
amendment  to the grant  instrument  (the "Grant  Instrument").  The Board shall
approve  the  form and  provisions  to each  Grant  Instrument.  Grants  under a
particular Section of the Plan need not be uniform as among the grantees.

         3.       Shares Subject to the Plan

        (a) Shares  Authorized.  Subject  to  adjustment as described below, the
aggregate number of shares of common stock of the Company ("Company Stock") that
may be  issued or  transferred  under the Plan is  24,682  shares.  The  maximum
aggregate number of shares of Company Stock that shall be subject to Grants made
under  the Plan to any  individual  during  any  calendar  year  shall be 24,682
shares,  subject to adjustment as described  below. The shares may be authorized
but unissued  shares of Company  Stock or  reacquired  shares of Company  Stock,
including shares purchased by the Company on the open market for purposes of the
Plan. If and to the extent Options granted under the Plan terminate,  expire, or
are canceled, forfeited,  exchanged or surrendered without having been exercised
or if any shares of Restricted  Stock are forfeited,  the shares subject to such
Grants shall again be available  for purposes of the Plan.  If shares of Company
Stock are used to pay the  exercise  price of an Option,  only the net number of
shares received by the grantee  pursuant to such exercise shall be considered to
have been issued or transferred under the Plan with respect to such Option,  and
the  remaining  number of shares  subject to the Option shall again be available
for purposes of the Plan.

         (b) Adjustments. If there is any change in the number or kind of shares
of  Company  Stock  outstanding  (i) by  reason of a stock  dividend,  spin-off,
recapitalization,  stock split,  or combination  or exchange of shares,  (ii) by
reason of a merger,  reorganization or consolidation in which the Company is the
surviving  corporation,  (iii) by reason of a reclassification  or change in par
value,  or (v) by reason of any other  extraordinary  or unusual event affecting
the  outstanding  Company  Stock as a class  without  the  Company's  receipt of
consideration,  or if the  value  of  outstanding  shares  of  Company  Stock is
substantially  reduced as a result of a spin-off or the Company's  payment of an
extraordinary dividend or distribution,  the maximum number of shares of Company
Stock  available for Grants,  the maximum number of shares of Company Stock that
any individual  participating in the Plan may be granted in any year, the number
of shares  covered by  outstanding  Grants,  the kind of shares issued under the
<PAGE>

Plan,  and the price per share of such Grants may be  appropriately  adjusted by
the Board to reflect any increase or decrease in the number of, or change in the
kind or value of,  issued  sharers of Company  Stock to preclude,  to the extent
practicable,  the  enlargement  or  dilution  of right and  benefits  under such
Grants;  provided,  however,  that any  fractional  shares  resulting  from such
adjustment shall be eliminated. Any adjustments determined by the Board shall be
final, binding and conclusive.

         4.       Eligibility for Participation

         (a) Eligible  Persons.  All employees of Principia and its subsidiaries
("Employees"),  and members of the Board of Directors of Principia  who were not
Employees  ("Non-Employee  Directors") were eligible to participate in the Plan.
Consultants  and advisors  who  performed  services for  Principia or any of its
subsidiaries  ("Key  Advisors")  were eligible to participate in the Plan if the
Key Advisors rendered bona fide services to Principia or its  subsidiaries,  the
services  were not in  connection  with the  offer and sale of  securities  in a
capital-raising transaction, and the Key Advisors did not directly or indirectly
promote or maintain a market for the Company's  securities.  Effective September
8, 2000, outstanding options granted under the Plan to purchase Principia common
stock are  cancelled  and are  replaced  by  options  granted  under the Plan to
purchase the Company  Stock,  and  outstanding  awards of  restricted  Principia
common stock granted under the Plan are replaced by awards of restricted Company
Stock, all pursuant to the terms of the Merger  Agreement.  No other awards will
be granted under the Plan after September 8, 2000.

         (b)  Selection  of  Grantees.  The Board  shall  select the  Employees,
Non-Employee  Directors and Key Advisors to receive  Grants and shall  determine
the number of shares of Company  Stock  subject  to a  particular  Grant in such
manner  as the  Board  determines.  Employees,  Key  Advisors  and  Non-Employee
Directors who receive Grants under this Plan shall hereinafter be referred to as
"Grantees".

         5.       Granting of Options

         (a) Number of Shares. The Board shall determine the number of shares of
Company  Stock that will be  subject  to each  Grant of  Options  to  Employees,
Non-Employee Directors and Key Advisors.

         (b)      Type of Option and Price

                  (i) The Board  may  grant  Incentive  Stock  Options  that are
intended to qualify as "incentive  stock options"  within the meaning of section
422 of the  Code or  Nonqualified  Stock  Options  that are not  intended  so to
qualify or any  combination of Incentive  Stock Options and  Nonqualified  Stock
Options,  all in  accordance  with the terms and  conditions  set forth  herein.
Incentive  Stock  Options may be granted only to Employees.  Nonqualified  Stock
Options may be granted to Employees, Non-Employee Directors and Key Advisors.

<PAGE>

                  (ii) The  purchase  price  (the  "Exercise  Price") of Company
Stock subject to an Option shall be determined by the Board and may be equal to,
greater than,  or less than the Fair Market Value (as defined  below) of a share
of Company Stock on the date the Option is granted; provided,  however, that (x)
the Exercise  Price of an  Incentive  Stock Option shall be equal to, or greater
than,  the  Fair  Market  Value  of a share  of  Company  Stock  on the date the
Incentive  Stock Option is granted and (y) an Incentive  Stock Option may not be
granted to an Employee  who, at the time of grant,  owns stock  possessing  more
than ten percent of the total  combined  voting power of all classes of stock of
the Company or any parent or  subsidiary  of the  Company,  unless the  Exercise
Price per share is not less than 110% of the Fair Market Value of Company  Stock
on the date of grant.

                  (iii) If the Company Stock is publicly  traded,  then the Fair
Market  Value per share shall be  determined  as follows:  (x) if the  principal
trading  market for the Company Stock is a national  securities  exchange or the
NASDAQ  National  Market,  the last  reported sale price thereof on the relevant
date or (if there were no trades on that date) the  latest  preceding  date upon
which a sale was reported, or (y) if the Company Stock is not principally traded
on such exchange or market, the mean between the last reported "bid" and "asked"
prices of Company  Stock on the relevant  date, as reported on NASDAQ or, if not
so reported,  as reported by the National  Daily  Quotation  Bureau,  Inc. or as
reported in a customary  financial  reporting service,  as applicable and as the
Board  determines.  If the Company Stock is not publicly  traded or, if publicly
traded, is not subject to reported  transactions or "bid" or "asked"  quotations
as set forth above,  the Fair Market Value per share shall be as  determined  by
the Board.

         (c) Option Term. The Board shall determine the term of each Option. The
term of any Option  shall not exceed ten years from the date of grant.  However,
an  Incentive  Stock  Option that is granted to an Employee  who, at the time of
grant,  owns stock possessing more than ten percent of the total combined voting
power of all classes of stock of the Company, or any parent or subsidiary of the
Company, may not have a term that exceeds five years from the date of grant.

         (d)  Exercisability  of Options.  Options shall become  exercisable  in
accordance with such terms and  conditions,  consistent with the Plan, as may be
determined  by the Board and  specified in the Grant  Instrument.  The Board may
accelerate the exercisability of any or all outstanding  Options at any time for
any reason.

<PAGE>

         (e)      Termination of Employment, Disability or Death

                  (i) Except as provided  below, an Option may only be exercised
while the Grantee is  employed  by, or  providing  service to, the Company as an
Employee, Key Advisor or member of the Board. In the event that a Grantee ceases
to be employed by, or provide  service to, the Company for any reason other than
Disability,  death,  or  termination  for Cause,  any Option  which is otherwise
exercisable by the Grantee shall terminate unless exercised within 90 days after
the date on which the Grantee  ceases to be employed by, or provide  service to,
the  Company  (or within such other  period of time as may be  specified  by the
Board),  but in any event no later  than the date of  expiration  of the  Option
term.  Except as otherwise  provided by the Board, any of the Grantee's  Options
that are not otherwise exercisable as of the date on which the Grantee ceases to
be employed by, or provide  service to, the Company  shall  terminate as of such
date.

                  (ii) In the event the  Grantee  ceases to be  employed  by, or
provide  service  to, the Company on account of a  termination  for Cause by the
Company,  any Option  held by the  Grantee  shall  terminate  as of the date the
Grantee  ceases to be  employed  by, or  provide  service  to, the  Company.  In
addition,  notwithstanding  any other provisions of this Section 5, if the Board
determines that the Grantee has engaged in conduct that constitutes Cause at any
time while the Grantee is employed by, or  providing  service to, the Company or
after the Grantee's termination of employment or service, any Option held by the
Grantee shall immediately terminate, and the Grantee shall automatically forfeit
all shares  underlying any exercised  portion of an Option for which the Company
has not yet delivered the share certificates,  upon refund by the Company of the
Exercise  Price paid by the Grantee  for such  shares.  Upon any  exercise of an
Option,  the  Company  may  withhold  delivery  of  share  certificates  pending
resolution of an inquiry that could lead to a finding resulting in a forfeiture.

                  (iii) In the event the Grantee  ceases to be  employed  by, or
provide  service to, the Company  because  the Grantee is  Disabled,  any Option
which is otherwise  exercisable by the Grantee shall terminate  unless exercised
within one year after the date on which the Grantee ceases to be employed by, or
provide  service to, the Company (or within such other  period of time as may be
specified by the Board),  but in any event no later dm the date of expiration of
the Option term. Except as otherwise provided by the Board, any of the Grantee's
Options which are not otherwise  exercisable as of the date on which the Grantee
ceases to be employed by, or provide  service to, the Company shall terminate as
of such date.

                  (iv) If the  Grantee  dies  while  employed  by, or  providing
service  to, the  Company or within 90 days after the date on which the  Grantee
ceases to be employed or provide  service on account of a termination  specified
in  Section  5(e)(i)  above  (or  within  such  other  period  of time as may be
specified by the Board), any Option that is otherwise exercisable by the Grantee
shall  terminate  unless  exercised  within one year after the date on which the
Grantee ceases to be employed by, or provide  service to, the Company (or within
such other period of time as may be specified by the Board), but in any event no
later  than the date of  expiration  of the  Option  term.  Except as  otherwise
provided  by the Board,  any of the  Grantee's  Options  that are not  otherwise
exercisable  as of the date on which the Grantee  ceases to be  employed  by, or
provide service to, the Company shall terminate as of such date.

                  (v)      For purposes of this Section 5(e) and Section 6:

                  (A) The term  "Company"  shall mean the Company and its parent
         and subsidiary  corporations  or other  entities,  as determined by the
         Board.
<PAGE>

                  (B)  "Employed by, or provide  service to, the Company"  shall
         mean employment or service as an employee, key advisor or member of the
         Board of Director of the Company or Principia (so that, for purposes of
         exercising Options and satisfying conditions with respect to Restricted
         Stock, a Grantee shall not be considered to have terminated  employment
         or service until the Grantee  ceases to be an employee,  key advisor or
         member of the Board of Director of the  Company or  Principia),  unless
         the Board determines otherwise.

                  (C) "Disability"  shall mean a Grantee's becoming disabled
         within the meaning of section 22(e)(3) of the Code.

                  (D)  "Cause"  shall  mean,  except  to  the  extent  specified
         otherwise by the Board, a finding by the Board that the Grantee (i) has
         breached his or her  employment  or service  contract with the Company,
         (ii) has  engaged in  disloyalty  to the  Company,  including,  without
         limitation,  fraud,  embezzlement,  theft,  commission  of a felony  or
         proven  dishonesty  in the course of his or her  employment or service,
         (iii) has disclosed  trade secrets or  confidential  information of the
         Company to persons not entitled to receive such information or (iv) has
         engaged in such other  behavior  detrimental  to the  interests  of the
         Company as the Board determines.

         (f)  Exercise  of Options.  A Grantee  may  exercise an Option that has
become  exercisable,  in whole or in part, by delivering a notice of exercise to
the Company  with  payment of the  Exercise  Price.  The  Grantee  shall pay the
Exercise Price for an Option as specified by the Board (x) in cash, (y) with the
approval  of the  Board,  by  delivering  shares of Company  Stock  owned by the
Grantee  (including Company Stock acquired in connection with the exercise of an
Option,  subject to such restrictions as the Board deems appropriate) and having
a Fair Market Value on the date of exercise  equal to the  Exercise  Price or by
attestation  (on a form  prescribed  by the  Board)  to  ownership  of shares of
Company  Stock having a Fair Market  Value on the date of exercise  equal to the
Exercise Price, or (z) by such other method as the Board may approve,  including
(after a Public Offering) payment through a broker in accordance with procedures
permitted by Regulation T of the Federal Reserve Board.  The Board may authorize
loans by the Company to Grantees in  connection  with the exercise of an Option,
upon such terms and  conditions  as the  Board,  in its sole  discretion,  deems
appropriate.  Shares of Company Stock used to exercise an Option shall have been
held by the Grantee for the requisite period of time to avoid adverse accounting
consequences  to the Company with respect to the Option.  The Grantee  shall pay
the  Exercise  Price and the  amount of any  withholding  tax due  (pursuant  to
Section 7) at the time of exercise.

         (g) Limits on Incentive  Stock  Options.  Each  Incentive  Stock Option
shall provide that, if the aggregate  Fair Market Value of the stock on the date
of the grant with respect to which  Incentive  Stock Options are exercisable for
the first time by a Grantee  during  any  calendar  year,  under the Plan or any
other  stock  option  plan of the  Company  or a parent or  subsidiary,  exceeds
$100,000,  then the Option, as to the excess, shall be treated as a Nonqualified
Stock option.  An Incentive  Stock Option shall not be granted to any person who
is not an Employee of the Company or a parent or subsidiary  (within the meaning
of section 424(f) of the Code).
<PAGE>

         6.       Restricted Stock Grants

         The Board may issue or transfer shares of Company Stock to an Employee,
Non-Employee  Director or Key Advisor  under a Grant of Restricted  Stock,  upon
such  terms  as the  Board  deems  appropriate.  The  following  provisions  are
applicable to Restricted Stock:

         (a) General Requirements. Shares of Company Stock issued or transferred
pursuant  to  Restricted   Stock  Grants  may  be  issued  or  transferred   for
consideration  or  for no  consideration,  and  subject  to  restrictions  or no
restrictions,  as  determined by the Board.  The Board may establish  conditions
under which restrictions on shares of Restricted Stock shall lapse over a period
of time or according to such other criteria as the Board deems appropriate.  The
period  of time  during  which the  Restricted  Stock  will  remain  subject  to
restrictions  will be  designated in the Grant  Instrument  as the  "Restriction
Period."

         (b) Number of Shares. The Board shall determine the number of shares of
Company Stock to be issued or transferred  pursuant to a Restricted  Stock Grant
and the restrictions applicable to such.

         (c)  Requirement of Employment or Service.  If the Grantee ceases to be
employed  by, or provide  service to, the  Company (as defined in Section  5(e))
during a period designated in the Grant Instrument as the Restriction Period, or
if other  specified  conditions  are not met, the  Restricted  Stock Grant shall
terminate  as to all shares  covered  by the Grant as to which the  restrictions
have not lapsed, and those shares of Company Stock must be immediately  returned
to the  Company.  The Board  may,  however,  provide  for  complete  or  partial
exceptions to this requirement as it deems appropriate.

         (d)  Restrictions on Transfer and Legend on Stock  Certificate.  During
the Restriction  Period,  a Grantee may not sell,  assign,  transfer,  pledge or
otherwise  dispose  of the  shares of  Restricted  Stock  except to a  Successor
Grantee under Section 8(a).  Each  certificate  for a share of Restricted  Stock
shall  contain a legend giving  appropriate  notice of the  restrictions  in the
Grant.  The Grantee shall be entitled to have the legend  removed from the stock
certificate covering the shares subject to restrictions when all restrictions on
such shares have lapsed. The Board may determine that the Company will not issue
certificates  for shares of  Restricted  Stock  until all  restrictions  on such
shares have lapsed,  or that the Company will retain  possession of certificates
for shares of  Restricted  Stock  until all  restrictions  on such  shares  have
lapsed.

         (e) Right to Vote and to  Receive  Dividends.  During  the  Restriction
Period,  the Grantee shall have the right to vote shares of Restricted Stock and
to receive any dividends or other distributions paid on such shares,  subject to
any restrictions deemed appropriate by the Board.

         (f) Lapse of Restrictions. All restrictions imposed on Restricted Stock
shall lapse upon the  expiration of the  applicable  Restriction  Period and the
satisfaction of all conditions imposed by the Board. The Board may determine, as
to any or all Restricted Stock Grants, that the restrictions shall lapse without
regard to any Restriction Period.
<PAGE>

         7.       Withholding of Taxes

         (a) Required Withholding. All Grants under the Plan shall be subject to
applicable   federal   (including   FICA),   state  and  local  tax  withholding
requirements. The Company may require that the Grantee or other person receiving
or  exercising  Grants pay to the  Company the amount of any  federal,  state or
local  taxes that the  Company is  required  to  withhold  with  respect to such
Grants,  or the  Company  may deduct  from other  wages paid by the  Company the
amount of any withholding taxes due with respect to such Grants.

         (b) Election to Withhold Shares. If the Board so permits, a Grantee may
elect to satisfy the Company's income tax withholding obligation with respect to
a Grant by having  shares  withheld  up to an amount  that does not  exceed  the
Grantee's minimum applicable  withholding tax rate for federal (including FICA),
state and local  tax  liabilities.  The  election  must be in a form and  manner
prescribed by the Board and may be subject to the prior approval of the Board.

         8.       Transferability of Grants

         (a)  Nontransferability  of Grants.  Except as provided below, only the
Grantee may  exercise  rights  under a Grant during the  Grantee's  lifetime.  A
Grantee  may not  transfer  those  rights  except  by the  laws of  descent  and
distribution  or, with respect to Grants other than Incentive Stock Options,  if
permitted in any specific  case by the Board,  pursuant to a domestic  relations
order (as defined  under the Code or Title I of the Employee  Retirement  Income
Security Act of 1974, as amended, or the regulations thereunder). When a Grantee
dies,  the personal  representative  or other person  entitled to succeed to the
rights  of the  Grantee  ("Successor  Grantee")  may  exercise  such  rights.  A
Successor  Grantee must furnish proof  satisfactory to the Company of his or her
right to receive the Grant under the Grantee's will or under the applicable laws
of descent and distribution.

         (b)  Transfer  of  Nonqualified  Stock  Options.   Notwithstanding  the
foregoing,  the Board may  provide,  in a Grant  Instrument,  that a Grantee may
transfer  Nonqualified Stock Options to family members, or one or more trusts or
other entities for the benefit of or owned by family  members,  consistent  with
applicable  securities laws, according to such terms as the Board may determine;
provided  that the Grantee  receives  no  consideration  for the  transfer of an
Option and the transferred Option shall continue to be subject to the same terms
and conditions as were applicable to the Option immediately before the transfer.

         9.       Right of First Refusal; Repurchase Right

         (a) Offer.  Prior to a Public  Offering,  if at any time an  individual
desires to sell, encumber,  or otherwise dispose of shares of Company Stock that
were  issued  or  distributed  to  him or her  under  this  Plan  and  that  are
transferable, the individual may do so only pursuant to a bona fide arm's length
written offer, and the individual shall first offer the shares to the Company by
giving the  Company  written  notice  disclosing:  (a) the name of the  proposed
transferee of the Company Stock; (b) the certificate number and number of shares
of Company Stock  proposed to be  transferred  or  encumbered;  (c) the proposed
price; (d) all other terms of the proposed  transfer;  and (e) a written copy of
the proposed  offer.  Within 60 days after  receipt of such notice,  the Company
shall have the option to purchase all or part of such Company  Stock at the then
current Fair Market Value (as defined in Section 5(b)) and may pay such price in
installments  over a period not to exceed four years,  at the  discretion of the
Board.
<PAGE>

         (b) Sale.  In the event the Company  (or a  stockholder,  as  described
below) does not  exercise  the option to  purchase  Company  Stock,  as provided
above,  the  individual  shall have the right to sell,  encumber,  or  otherwise
dispose of the shares of Company Stock  described in subsection (a) on the terms
of the transfer set forth in the written  notice to the Company,  provided  such
transfer is effected  within 15 days after the  expiration of the option period.
The Committee  may require that the  transferee of such shares agree to be bound
by the terms of this  Section 9 or a  stockholder's  agreement  as  described in
subsection (e) below.  If the transfer is not effected  within such period,  the
Company must again be given an option to purchase, as provided above.

         (c) Assignment of Rights. The Board, in its sole discretion, may waive,
in whole or in part, the Company's  right of first refusal and repurchase  right
under this Section 9. In the event of such a waiver,  the Board may, in its sole
discretion,  assign to the  Company's  stockholders,  as described  below,  that
portion of the Company's  right of first refusal and  repurchase  right that has
been so  waived,  in which case such  portion  shall be  assigned  to the "Large
Stockholders" (as that term is defined in the Stockholders' Agreement,  dated as
of July 14,  1999,  among the  Company  and  certain  of its  stockholders  (the
"Stockholders  Agreement")) and the holders of Series A-2 Preferred Stock of the
Company (collectively, the "assignee stockholders").  The rights so assigned may
be exercised by the assignee  stockholders in the same proportion that each such
assignee  stockholder's stock ownership bears to the stock ownership of all such
assignee  stockholders.  If the assignee stockholders do not exercise all of the
rights so assigned to them,  the Board may, in its sole  discretion,  assign the
unexercised  rights  to  any or all of  the  stockholders  of the  Company  (the
"subsequent  assignee  stockholders")  in the same  proportion  that  each  such
subsequent  assignee  stockholder's stock ownership bears to the stock ownership
of all the subsequent assignee stockholders of the Company, as determined by the
Board. To the extent that a subsequent assignee  stockholder has been given such
right and does not purchase his or her allotment,  the other subsequent assignee
stockholders shall have the right to purchase such allotment on that same basis.

         (d) Purchase by the Company.  Prior to a Public Offering,  if a Grantee
ceases to be employed by, or provide service to, the Company,  the Company shall
have  the  right  to  purchase  all or  part  of any  Company  Stock  issued  or
distributed  to him or her under this Plan at its then current Fair Market Value
(as defined in Section  5(b)) (or at such other price as may be  established  in
the Grant Instrument);  provided, however, that such repurchase shall be made in
accordance  with  applicable   accounting  rules  to  avoid  adverse  accounting
treatment.

         (e)  Stockholder's  Agreement.  Notwithstanding  the provisions of this
Section  9,  if the  Board  requires  that a  Grantee  execute  a  stockholder's
agreement  with respect to any Company Stock issued or  distributed  pursuant to
this Plan,  the  provisions  of this  Section 9 shall not apply to such  Company
Stock.

         10.      Change of Control of the Company

         As used herein,  a "Change in Control" shall be deemed to have occurred
if:
<PAGE>

         (a) Any "person"  (as such term is used in Sections  13(d) and 14(d) of
the Exchange Act) (other than persons who are stockholders on the effective date
of the Plan)  becomes a  "beneficial  owner" (as defined in Rule 13d-3 under the
Exchange Act), directly or indirectly, of securities of the Company representing
more than 50% of the  voting  power of the then  outstanding  securities  of the
Company;  provided  that a Change of  Control  shall not be deemed to occur as a
result of a change of ownership resulting from the death of a stockholder, and a
Change of Control shall not be deemed to occur as a result of a  transaction  in
which the Company  becomes a subsidiary of another  corporation and in which the
stockholders  of  the  Company,  immediately  prior  to  the  transaction,  will
beneficially  own,  immediately  after the  transaction,  shares  entitling such
stockholders  to more  than 50% of all votes to which  all  stockholders  of the
parent  corporation  would be entitled in the  election  of  directors  (without
consideration  of the  rights  of any  class of stock  to elect  directors  by a
separate class vote); or

         (b)  The  stockholders  of the  Company  approve  (or,  if  stockholder
approval is not required, the Board approves) an agreement providing for (i) the
merger or  consolidation  of the  Company  with  another  corporation  where the
stockholders of the Company,  immediately  prior to the merger or consolidation,
will not beneficially own, immediately after the merger or consolidation, shares
entitling  such  stockholders  to  more  than  50% of all  votes  to  which  all
stockholders of the surviving  corporation  would be entitled in the election of
directors  (without  consideration  of the rights of any class of stock to elect
directors by a separate class vote),  (ii) the sale or other  disposition of all
or  substantially  all of the assets of the Company,  or (iii) a liquidation  or
dissolution of the Company.

         11.      Consequences of a Change in Control

         (a) Assumption of Grants. Upon a Change of Control where the Company is
not the  surviving  corporation  (or survives  only as a  subsidiary  of another
corporation),  unless the Board determines  otherwise,  all outstanding  Options
that are not exercised shall be assumed by, or replaced with comparable  options
by  the  surviving  corporation,  and  outstanding  Restricted  Stock  shall  be
converted to restricted stock of the surviving corporation.

         (b) Other  Alternatives.  Notwithstanding  the  foregoing,  subject  to
subsection  (c) below,  in the event of a Change of Control,  the Board may take
any of the following actions with respect to any or all outstanding  Grants: the
Board may (i) determine that outstanding Options shall automatically  accelerate
and  become  fully  exercisable  and that the  restrictions  and  conditions  on
outstanding Restricted Stock shall immediately lapse, (ii) require that Grantees
surrender their outstanding Options in exchange for a payment by the Company, in
cash or Company  Stock as  determined  by the Board,  in an amount  equal to the
amount by which the then  Fair  Market  Value of the  shares  of  Company  Stock
subject to the Grantee's  unexercised  Options exceeds the Exercise Price of the
Options  or (iii)  after  giving  Grantees  an  opportunity  to  exercise  their
outstanding  Options,  terminate any or all unexercised  Options at such time as
the Board deems  appropriate.  Such surrender or termination shall take place as
of the date of the  Change  of  Control  or such  other  date as the  Board  may
specify.  The  Board  shall  have no  obligation  to take  any of the  foregoing
actions,  and,  in the  absence of any such  actions,  outstanding  Options  and
Restricted  Stock shall continue in effect  according to their terms (subject to
any assumption pursuant to subsection (a)).
<PAGE>

         (c) Limitations.  Notwithstanding anything in the Plan to the contrary,
in the event of a Change of Control,  the Board shall not have the right to take
any  actions  described  in  the  Plan  (including  without  limitation  actions
described  in  subsection  (b)  above)  that  would  make the  Change of Control
ineligible for pooling of interests  accounting treatment or that would make the
Change of Control  ineligible  for desired tax  treatment  if, in the absence of
such  right,  the Change of Control  would  qualify for such  treatment  and the
Company intends to use such treatment with respect to the Change of Control.

         12.      Requirements for Issuance or Transfer of Shares

         (a)  Stockholder's  Agreement.  The  Board may  require  that a Grantee
execute  a  stockholder's  agreement,   with  such  terms  as  the  Board  deems
appropriate, with respect to any Company Stock issued or distributed pursuant to
this Plan.

         (b)  Limitations  on Issuance or Transfer of Shares.  No Company  Stock
shall be issued or transferred in connection with any Grant hereunder unless and
until all legal  requirements  applicable  to the  issuance  or transfer of such
Company  Stock have been  complied with to the  satisfaction  of the Board.  The
Board shall have the right to condition any Grant made to any Grantee  hereunder
on such Grantee's undertaking in writing to comply with such restrictions on his
or her subsequent disposition of such shares of Company Stock as the Board shall
deem necessary or advisable,  and certificates  representing  such shares may be
legended to reflect any such restrictions.  Certificates  representing shares of
Company  Stock  issued or  transferred  under the Plan will be  subject  to such
stop-transfer  orders and other  restrictions  as may be required by  applicable
laws,  regulations and interpretations,  including any requirement that a legend
be placed thereon.

         (c)  Lock-Up   Period.   If  so   requested   by  the  Company  or  any
representative  of the underwriters  (the "Managing  Underwriter") in connection
with any registration of the offering of any securities of the Company under the
Securities Act of 1933, as amended (the "Securities  Act"), a Grantee (including
any  successor or assigns)  shall not sell or  otherwise  transfer any shares or
other  securities  of the  Company  during  the  180-day  period  following  the
effective  date of a  registration  statement  of the  Company  filed  under the
Securities  Act (or such  other  period as may be  requested  in  writing by the
Managing  Underwriter  and  agreed to in writing by the  Company)  (the  "Market
Standoff  Period").  Such restriction shall apply only to the first registration
statement  of the  Company to become  effective  under the  Securities  Act that
includes  securities  to be sold on behalf of the  Company  to the  public in an
underwritten  public  offering under the Securities  Act. The Company may impose
stop-transfer  instructions with respect to securities  subject to the foregoing
restrictions until the end of such Market Standoff Period.

         (d)  Certain Prohibited Transfers.  Notwithstanding any other provision
of the Plan:

                  (i) Until a registration  statement with respect to an initial
public  offering  of the  Company's  stock is declared  effective  by the United
States  Securities  and Exchange  Commission,  a Grantee shall not in any manner
transfer  or sell any shares of  Company  Stock to any person who is listed as a
prohibited  sublicensee  in the  License  Agreement  dated  July 14,  1999  (the
"License Agreement"),  among the Company,  Centeon L.L.C.,  Centeon Pharma GmbH,
Centeon Bio-Services, Inc. and Delta Biotechnology Limited.
<PAGE>

                  (ii) Each  certificate  for shares of Company  Stock held by a
Grantee  shall  contain a legend giving  appropriate  notice of the  restriction
imposed by this Section 12(d).

                  (iii) The provisions of this  subsection (d) shall survive the
termination  of the Plan  and  shall  continue  to  apply  until a  registration
statement with respect to an initial public  offering of the Company's  stock is
declared effective by the United States Securities and Exchange Commission.

         13.      Amendment and Termination of the Plan

         (a)  Amendment.  The Board may amend or terminate the Plan at any time;
provided,  however,  that the Board shall not amend the Plan without stockholder
approval  if such  approval is required  in order for  Incentive  Stock  Options
granted or to be granted under the Plan to meet the  requirements of section 422
of the Code or, after a Public  Offering,  such approval is required in order to
exempt compensation under the Plan from the deduction limit under section 162(m)
of the Code.

         (b)   Termination  of  Plan.  The  Plan  shall  terminate  on  the  day
immediately  preceding the tenth  anniversary of its effective date,  unless the
Plan is  terminated  earlier by the Board or is  extended  by the Board with the
approval of the stockholders.

         (c) Termination and Amendment of Outstanding  Grants.  A termination or
amendment  of the Plan that  occurs  after a Grant is made shall not  materially
impair the rights of a Grantee  unless the Grantee  consents or unless the Board
acts under Section 18(b). The termination of the Plan shall not impair the power
and authority of the Board with respect to an outstanding Grant.  Whether or not
the plan has terminated, an outstanding Grant may be terminated or amended under
Section  19(b) or may be amended by  agreement  of the  Company  and the Grantee
consistent with the Plan.

         (d) Governing  Document.  The Plan shall be the  controlling  document.
No other statements, representations, explanatory materials or examples, oral or
written,  may amend the Plan in any  manner.  The Plan shall be binding  upon an
enforceable against the Company and its successors and assigns.

         (e) Certain Amendments Prohibited. Notwithstanding any other provisions
of the Plan:

                  (i) Until the first to occur of (A) the date that the  holders
of Series A-2 Preferred Stock of the Company (the "Series A-2 Stockholders") own
less  than 3% of the  Company  Stock  or (B) the date of a First  Approval  of a
Licensed  Product in a Major Territory (as such terms are defined in the License
Agreement),  no modification,  amendment or waiver,  temporary or permanent,  of
Section 9(c) or 12(d) or this  Section  13(e) which is adverse to the Series A-2
Preferred Stock may be made without the written consent of (x) the Board and (y)
the  holders  of a  majority  of the  voting  power of the  shares of Series A-2
Preferred Stock then  outstanding.  The percentage of Company Stock owned by the
Series A-2 Stockholders  shall be computed in the manner set forth in Section 13
of the Stockholders Agreement.
<PAGE>

                  (ii) Any  modification,  amendment  or  waiver,  temporary  or
permanent,  of  Section  9(c) or 12(d)  or this  Section  13(e)  that (A) is not
adverse  to the  Series  A-2  Stockholders  or (B) is  adverse to the Series A-2
Stockholders  but arises after the  occurrence of either event (A) or (B) listed
in the first  sentence of  subsection  (e)(i) above may be made only pursuant to
the  written  consent of (x) the Board and (y) the  holders of a majority of the
voting power of the Series A Preferred Stock of the Company.

         14.      Funding of the Plan

         This Plan shall be  unfunded.  The  Company  shall not be  required  to
establish  any  special or  separate  fund or to make any other  segregation  of
assets to assure the  payment of any Grants  under this Plan.  In no event shall
interest  be paid or accrued  on any Grant,  including  unpaid  installments  of
Grants.

         15.      Rights of Participants

         Nothing  in  this  Plan  shall  entitle  any  Employee,   Key  Advisor,
Non-Employee  Director  or other  person to any  claim or right to be  granted a
Grant under this Plan. Neither this Plan nor any action taken hereunder shall be
construed as giving any individual any rights to be retained by or in the employ
of the Company or any other employment rights.

         16.      No Fractional Shares

         No  fractional  shares of Company  Stock  shall be issued or  delivered
pursuant to the Plan or any Grant. The Board shall determine whether cash, other
awards or other  property  shall be  issued  or paid in lieu of such  fractional
shares  or  whether  such  fractional  shares  or any  rights  thereto  shall be
forfeited or otherwise eliminated.

         17.      Headings

         Section  headings are for  reference  only.  In the event of a conflict
between a title and the content of a Section,  the content of the Section  shall
control.

         18.      Effective Date of the Plan

         (a) Effective Date.  Subject to approval by the Company's stockholders,
the Plan shall be effective on September 8, 1999.

         (b) Public Offering.  The provisions of the Plan that refer to a Public
Offering,  or that refer to, are applicable to persons subject to, section 16 of
the Exchange Act or section 162(m) of the Code,  shall be effective,  if at all,
upon the initial  registration  of the Company  Stock under section 12(g) of the
Exchange Act, and shall remain effective thereafter for so long as such stock is
so registered.
<PAGE>

         19.      Miscellaneous

         (a) Grants in Connection  with  Corporate  Transactions  and Otherwise.
Nothing  contained in this Plan shall be construed to (i) limit the right of the
Board to make Grants  under this Plan in  connection  with the  acquisition,  by
purchase,  lease, merger,  consolidation or otherwise, of the business or assets
of any corporation,  firm or association,  including Grants to employees thereof
who become Employees of the Company, or for other proper corporate purposes,  or
(ii) limit the right of the Company to grant stock  options or make other awards
outside of this Plan. Without limiting the foregoing, the Board may make a Grant
to an  employee  of another  corporation  who becomes an Employee by reason of a
corporate   merger,   consolidation,   acquisition   of   stock   or   property,
reorganization  or liquidation  involving the Company or any of its subsidiaries
in  substitution  for a stock  option or  restricted  stock  grant  made by such
corporation. The terms and conditions of the substitute grants may vary from the
terms and  conditions  required  by the Plan and from  those of the  substituted
stock  incentives.  The Board shall  prescribe the  provisions of the substitute
grants.

         (b)  Compliance  with Law.  The Plan,  the  exercise of Options and the
obligations  of the Company to issue or transfer  shares of Company  Stock under
Grants  shall  be  subject  to  all  applicable  laws  and to  approvals  by any
governmental  or regulatory  agency as may be required.  With respect to persons
subject to section 16 of the  Exchange  Act,  after a Public  Offering it is the
intent of the Company that the Plan and all  transactions  under the Plan comply
with a applicable  provisions of Rule 16b-3 or its successors under the Exchange
Act. In addition,  it is the intent of the Company that the Plan and  applicable
Grants under the Plan comply with the applicable provisions of section 162(m) of
the Code,  after a Public  Offering,  and section 422 of the Code. To the extent
that any legal  requirement  of section 16 of the Exchange Act or section 162(m)
or 422 of the Code as set forth in the Plan ceases to be required  under section
16 of the Exchange Act or section 162(m) or 422 of the Code, that Plan provision
shall cease to apply. The Board may revoke any Grant if it is contrary to law or
modify a Grant  to  bring  it into  compliance  with  any  valid  and  mandatory
government regulation.  The Board may also adopt rules regarding the withholding
of taxes on payments to Grantees.  The Board may, in its sole discretion,  agree
to limit its authority under this Section.

         (c)  Governing  Law. The  validity,  construction,  interpretation  and
effect of the Plan and Grant Instruments issued under the Plan shall be governed
and construed by and determined in accordance with the laws of the  Commonwealth
of  Pennsylvania,  without  giving  effect to the  conflict  of laws  provisions
thereof.

<PAGE>

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