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Exhibit 10.5.2    
  

 
 

STOCK OPTION AGREEMENT    
  

        Pursuant to the Grant Notice and this Stock Option Agreement, the Company has granted you an option to purchase the number of shares of the Company's common stock
("Common Stock") indicated in the Grant Notice at the exercise price indicated in the Grant Notice. 

        Your
option is granted in connection with and in furtherance of the Company's 2002 Stock Option Plan (the "Plan") for the Company's employees (including officers), directors or
consultants. Defined terms not explicitly defined in this Stock Option Agreement but defined in the Plan shall have the same definitions as in the Plan. 

        The
details of your option are as follows: 

        1.    VESTING. Subject to the limitations contained herein, your option will vest as provided in the Grant Notice, provided that
vesting will cease upon the termination of your Continuous Status as an Employee, Director or Consultant. The vesting schedule requires continued employment or service through each applicable vesting
date as a condition to the vesting of the applicable installment of the options and the rights and benefits under this Stock Option Agreement. Employment or service, even if substantial, for only a
portion of a vesting period will not entitle you to any proportionate vesting or avoid or mitigate a termination of rights and benefits upon or following a termination of employment or service as
provided herein. 

        2.    METHOD OF PAYMENT. Payment of the exercise price by cash or check is due in full upon exercise of all or any part of your
option. 

        3.    WHOLE SHARES; RIGHTS WITH RESPECT TO SHARES. Your option may only be exercised for whole shares. You will have no rights
or privileges of a stockholder of the Company as to any shares underlying the option until the issuance and delivery of a certificate evidencing the shares registered in
your name following the exercise of the option. No adjustment will be made for dividends or other rights as to a stockholder for which a record date is prior to such date of delivery. 

        4.    SECURITIES LAW COMPLIANCE. Notwithstanding anything to the contrary contained herein, your option may not be exercised
unless the shares issuable upon exercise of your option are then registered under the Securities Act of 1933, as amended (the "Securities Act"), or, if such shares are not then so registered, the
Company has determined that such exercise and issuance would be exempt from the registration requirements of the Securities Act. 

        5.    TERM. Subject to Section 10 of the Plan, the term of your option commences on the Date of Grant and expires upon
the earliest of: 

          (i)  the
Expiration Date indicated in the Grant Notice; 

        (ii)  the
tenth (10th) anniversary of the Date of Grant; 

        (iii)  eighteen
(18) months after your death, if you die during, or within three (3) months after the termination of your Continuous Status as Employee,
Director or Consultant; 

        (iv)  twelve
(12) months after the termination of your Continuous Status as Employee, Director or Consultant due to disability; 

        (v)  immediately
after the termination of your Continuous Status as Employee, Director or Consultant for Cause; or 

        (vi)  three
(3) months after the termination of your Continuous Status as an Employee, Director or Consultant for any other reason, provided that if during any part of
such three (3)-month period the option is not exercisable solely because of the condition set forth in paragraph 4 (Securities Law Compliance), in which event the option shall not expire until
the earlier of the 

 

Expiration Date or until it shall have been exercisable for an aggregate period of three (3) months after the termination of Continuous Status as an Employee, Director or Consultant. 

        For
these purposes, "Cause" shall include, but not be limited to, the commission of any act of fraud, embezzlement or dishonesty, any unauthorized use or disclosure of confidential
information or trade secrets of the Company or any of its Affiliates, or any other intentional misconduct adversely affecting the business or affairs of the Company or any of its Affiliates in a
material manner. The foregoing definition shall not be deemed to be inclusive of all the acts or omissions which the Company may consider as ground for your dismissal or discharge. 

        In
all cases, the option, to the extent not exercisable on the date your Continuous Status as an Employee, Director or Consultant terminates (regardless of the reason), shall terminate
on that date. 

        6.    EXERCISE.

        (a)  You
may exercise the vested portion of your option during its term by delivering a notice of exercise (in a form designated by the Company) together with the exercise
price to the Secretary of the Company, or to such other person as the Company may designate, during regular business hours, together with such additional documents as the Company may then require. 

        (b)  By
exercising your option you agree that: as a condition to any exercise of your option, the Company may require you to enter an arrangement providing for the payment by
you to the Company of any tax withholding obligation of the Company (and/or any of its Affiliates) arising by reason of the exercise of your option. 

        7.    TRANSFERABILITY. Your option is not transferable, except by will or by the laws of descent and distribution, and is
exercisable during your life only by you. Notwithstanding the foregoing, by delivering written notice to the Company, in a form satisfactory to the Company, you may designate a third party who, in the
event of your death, shall thereafter be entitled to exercise your option. 

        8.    OPTION NOT A SERVICE CONTRACT. Your option is not an employment contract and nothing in your option shall be deemed to
create in any way whatsoever any obligation on your part to continue in the employ of the Company or one of its Affiliates, or of the Company and its Affiliates to continue your employment with the
Company or any of its Affiliates. In addition, nothing in your option shall obligate the Company, any Affiliate, and their respective shareholders, board of directors, officers or employees to
continue any relationship which you might have as a director or consultant for the Company or one of its Affiliates. 

        9.    NOTICES. Any notices provided for in your option or the Plan shall be given in writing and shall be deemed effectively
given upon receipt or, in the case of notices delivered by the Company to you, five (5) days after deposit in the United States mail, postage prepaid, addressed to you at the last address you
provided to the Company. 

        10.  GOVERNING PLAN DOCUMENT. Your option is subject to all the provisions of the Plan, the provisions of which are hereby
made a part of your option, including without limitation the provisions of the Plan relating to option provisions, and is further subject to all interpretations, amendments, rules and regulations
which may from time to time be promulgated and adopted pursuant to the Plan. In the event of any conflict between the provisions of your option and those of the Plan, the provisions of the Plan shall
control. Unless otherwise expressly provided in this Stock Option Agreement, provisions of the Plan that confer discretionary authority on the Board (or a committee thereof) do not (and shall not be
deemed to) create any additional rights for you not expressly set forth in this Stock Option Agreement. 

2

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Exhibit 10.5.2

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Exhibit 10.12.3    
  

Execution Copy 

 
 
 

THIRD AMENDMENT AGREEMENT    
  

        THIS THIRD AMENDMENT AGREEMENT dated as of January 28, 2003 (this "Amendment Agreement"), by and between  VERSICOR INC., a Delaware corporation (the "Company"), and FLEET NATIONAL
BANK (the "Bank"). 

        WHEREAS,
the Bank and the Company wish to modify the provisions of the Loan Agreement (as defined herein) to add a new equipment loan, modify the terms of the Term Loan, and modify
certain financial covenants and other provisions of the Loan Agreement as set forth herein. 

        NOW,
THEREFORE, in consideration of the foregoing and the agreements contained herein, the parties hereby agree as follows: 

        1.    Reference to Loan Agreement.

        Reference
is made to that certain Revolving Credit, Term Loan and Security Agreement dated as of December 31, 1996, as amended by the First Amendment Agreement dated as of
December 30, 1997 and the Second Amendment Agreement dated as of October 22, 2001, and as extended by that certain Extension Letter dated as of December 27, 2002 (as the same may
be further amended, restated, supplemented or otherwise modified from time to time, the "Loan Agreement"), by and between the Company and the Bank.
Capitalized terms used herein which are defined in the Loan Agreement have the same meanings herein as therein, except to the extent that such meanings are amended hereby. 

        2.    Amendments.

        The
Company and the Bank agree that the Loan Agreement is hereby amended, effective as of the date hereof, as follows: 

        (a)  Additions to Section 1.1 of the Loan Agreement.    The following definitions are hereby added to
Section 1.1 of the Loan Agreement: 

        Annualized Cash Burn.    For any fiscal quarter of the Company, four times the Cash Burn for such fiscal quarter. For any fiscal
month of the Company, twelve times the Cash Burn for such fiscal month. 

        BI Acquisition.    See Section 6.6. 

        Biosearch Italia.    Biosearch Italia S.p.A., an Italian joint stock company. 

        Cash Burn.    For any fiscal period, the net loss of the Company and its Subsidiaries (determined on a consolidated basis
without duplication in accordance with GAAP) during such period, plus amortization and depreciation, minus  taxes paid in cash and Non-Financed Capital
Expenditures. 

        Cash Collateral Amount.    An amount equal to: 

        (1)  90%
of the notes, bonds or other obligations of the United States of America or any agency thereof that as to principal and interest constitute direct obligations of or
are guaranteed by the United States of America, and 

        (2)  cash,

each
held in a separate collateral account maintained by the Company at the Bank for the sole purpose of securing the outstanding principal amount of the Loans and in which the Bank has a perfected
first priority security interest. 

 

        Equipment Loan II Availability Period.    The period commencing on the date of the Second Amendment Agreement and ending on
December 31, 2003. 

        Equipment Loan II Commitment Amount.    One Million Five Hundred Thousand Dollars ($1,500,000). 

        Equipment Loan II Maturity Date.    December 31, 2005. 

        Foreign Subsidiary.    A corporation, partnership or limited liability company organized under the laws of any jurisdiction
other than the United States that becomes a Subsidiary of the Company. 

        Funded Senior Indebtedness.    The sum, for the Company and its Subsidiaries (determined on a consolidated basis without
duplication in accordance with GAAP), of all Indebtedness for borrowed money other than Subordinated Indebtedness. 

        Hedging Agreement.    Any interest rate protection agreement, foreign currency exchange agreement, commodity price protection
agreement or other interest or currency exchange rate or commodity price hedging arrangement. 

        Third Amendment Agreement.    The Third Amendment Agreement dated as of January 28, 2003 between the Bank and the
Company. 

        Total Liabilities.    As at any date, any and all liabilities of the Company and its Subsidiaries on such date on a consolidated
basis determined in accordance with GAAP, minus obligations of the Company to the Bank to the extent of the Cash Collateral Amount. 

        (b)  Modifications to Section 1.1 of the Loan Agreement.

            i.  The
definition of "Cash Equivalent Amount" is replaced by the following: "Cash Equivalent Amount. The sum of the
following, without duplication, none of which may be subject to any Encumbrances except for Encumbrances in favor of the Bank or any of its Affiliates: (1) cash held by the Company in the
United States, plus (2) Qualified Investments of the Company held in the United States, minus
(3) cash or Qualified Investments pledged to the Bank or any issuer of a letter of credit to secure the Company's reimbursement obligation with respect to such letter of credit." 

          ii.  The
definition of "Debt Service Coverage Ratio" is hereby modified to delete the words "twelve consecutive months" from such definition and replace them with the words
"four consecutive quarters". 

          iii.  The
definition of "Loans" is replaced by the following: "Loans. The Term Loan, the Equipment Loans and the Equipment Loans II." 

          iv.  The
definition of "Notes" is replaced by the following: "Notes. Collectively, the Term Note, the Equipment Note and the
Equipment Note II, each individually, a "Note."' All references in the Agreement to the "Term Notes" are hereby replaced by the "Term Note." 

          v.  The
definition of "Obligations" is modified by inserting the words "and Hedging Agreements" immediately after the word "Notes". 

        (c)  Modifications to Section 2 of the Loan Agreement.

            i.  Section 2.1(a)
of the Loan Agreement is hereby deleted and replaced by the following: 

        (a)  General Provisions.    Upon the terms and subject to the conditions set forth in the Third Amendment Agreement,
and in reliance upon the representations, warranties and covenants of the Company made herein and therein, the Bank agrees to make a term loan (the "Term
Loan") to 

2

 

the Company in the original principal amount of $2,801,500 for the purpose of refinancing the Term Loans made by the Bank to the Company on the date of the First Amendment Agreement. 

          ii.  Section 2.1(b)
of the Loan Agreement is hereby deleted and replaced by the following: 

        (b)  Term Note.    The Term Loan shall be evidenced by a Term Note, in the form attached hereto as  Exhibit F, payable to the order of the Bank in
the original principal amount of $2,801,500. The Term Note shall be dated the date of the Third
Amendment Agreement and shall have the blanks therein appropriately filled in. The Term Note shall bear interest at the rate or rates, and such interest shall be payable in the dates specified in
Section 2.8. 

          iii.  Section 2.4(c)
of the Loan Agreement is hereby deleted and replaced by the following: 

        (c)  The
outstanding principal amount of the Term Loan shall be payable in eight (8) equal quarterly installments, each such installment of principal equal to
$350,187.50, on the last Business Day of each calendar quarter commencing on March 31, 2003 with the final payment of the balance (together with any accrued interest and all other amounts due
hereunder by reason of the Term Loan) on December 31, 2004 or such earlier date that the balance shall have been reduced to zero.

          iv.  Section 2.8
of the Loan Agreement is hereby deleted and replaced by the following: 

        2.8  Interest.    The Notes shall bear interest on the unpaid principal amount thereof until paid in full at the
rate or rates per annum determined (on the basis of the actual number of days elapsed over a 360-day year) and payable as follows: 

        (a)  The
rate of interest for any portion of the outstanding principal amount of the Loans which, when added to the aggregate outstanding principal amount of all Loans, is
less than or equal to the Cash Collateral Amount and is not then subject to an exercised LIBOR Option under Section 2.9 shall be computed at the Prime Rate. 

        (b)  The
rate of interest for any portion of the outstanding principal amount of the Loans which, when added to the aggregate outstanding principal amount of all Loans,
exceeds the Cash Collateral Amount and is not then subject to an exercised LIBOR Option under Section 2.9 shall be computed at the Prime Rate  plus one-half percent 
(1/2%). 

        (c)  The
rate for any LIBOR Portion of the Loans which, when added to the aggregate outstanding principal amount of all Loans, is less than or equal to the Cash Collateral
Amount shall be computed at a rate equal to the applicable LIBOR Rate plus one percent (1%). 

        (d)  The
rate for any LIBOR Portion of the Loans which, when added to the aggregate outstanding principal amount of all Loans, exceeds the Cash Collateral Amount shall be
computed at a rate equal to the applicable LIBOR Rate plus three and one-quarter percent (31/4%). 

        (e)  If
at any time while Loans are outstanding and accruing interest under Sections 2.8(a) and/or 2.8(c), the aggregate principal amount of all Loans outstanding shall
exceed the Cash Collateral Amount or the Cash Collateral Amount shall be reduced to less than the aggregate principal amount of all Loans outstanding, the portion of the principal amount of Loans
accruing interest under Section 2.8(a) or 2.8(c) in excess of the then current Cash Collateral Amount shall, in the Bank's sole discretion, accrue interest under Section 2.8(b) or
2.8(d). 

        (f)    Interest
on the Notes shall be payable as follows: (i) interest on any Prime Rate Loan shall be payable monthly in arrears on the first Business Day of each
month, commencing on the first Business Day of March, 2003 and at maturity (whether by acceleration or otherwise); (ii) interest on any LIBOR Portion of the Loans in respect of any LIBOR Period
shall be payable on the last day of such LIBOR Period and at maturity (whether by acceleration or otherwise). A change in the rate of interest payable on any portion of the outstanding principal
balance of any 

3

 

Loan which is not then subject to a LIBOR Option shall take effect simultaneously with the corresponding change in the Prime Rate. 

          v.  Section 2.9
of the Loan Agreement is hereby deleted and replaced by the following: 

        2.9    Certain LIBOR Provisions.

        (a)  LIBOR Option.    Subject to the provisions of Section 2, 2A and 2B, as applicable, the Company shall
have the right to have the interest on all or any portion of the principal amount of any Loan based on a LIBOR Rate. 

        (b)  Certain Definitions.    As used herein, the following terms have the following respective meanings: 

        Banking Day.    (i) When used with respect to the LIBOR Option, a day on which transactions may be effected in deposits
of U.S. dollars in the London interbank foreign currency deposits market and on which banks may conduct business in London, England and Boston, Massachusetts and (ii) when used with respect to
the other provisions of this Agreement, any day excluding Saturday and Sunday and excluding any other day which shall be in Boston, Massachusetts, a legal holiday or a day on which banking
institutions are authorized by law to close. 

        Board.    The Board of Governors of the Federal Reserve System of the United States. 

        Legal Requirement.    Any requirement imposed upon the Bank by any law of the United States of America or the United Kingdom or
by any regulation, order, interpretation, ruling or official directive (whether or not having the force of law) of the Board, the Bank of England or any other board, central bank or governmental or
administrative agency, institution or authority of the United States of America, the United Kingdom or any political subdivision of either thereof. 

        LIBOR Option.    The option granted pursuant to this Section 2 to have the interest on all or a portion of the principal
amount of the Loans based on a LIBOR Rate. 

        LIBOR Period.    Any period, as provided below in this Section 2.9, of 30, 60 or 90 days, commencing on any
Banking Day; provided, however, that (i) no LIBOR Period with respect to any LIBOR Portion of the Term Loan shall extend beyond the Term Loan
Maturity Date, (ii) no LIBOR Period with respect to any LIBOR Portion of any Equipment Loan shall extend beyond the Equipment Loan Maturity Date, and (iii) no LIBOR Period with respect
to any LIBOR Portion of any Equipment Loan II shall extend beyond the Equipment Loan II Maturity Date. If any LIBOR Period so selected would otherwise end on a date which is not a Banking Day, such
LIBOR Period shall instead end on the next preceding or succeeding Banking Day as determined by the Bank in accordance with the then current banking practice in London. Each determination by the Bank
of any LIBOR Period shall, in the absence of manifest error, be conclusive, and at the Company's request the Bank shall demonstrate the basis for such determination. 

        LIBOR Portion.    That portion of the Loans specified in a LIBOR Request, (i) which is not less than Two Hundred Dollars
($250,000), (ii) which is an integral multiple of Ten Thousand Dollars ($10,000), (iii) which does not exceed the outstanding balance of the Loans not already subject to an exercised
LIBOR Option, (iv) which, as of the date of the LIBOR Request specifying such LIBOR Portion, has met the conditions for basing interest on the LIBOR Rate in Section 2.9A of this
Agreement and (v) the LIBOR Period of which has commenced and not terminated. 

        LIBOR Premium.    With respect to the prepayment of any LIBOR Portion of any Loan, whether voluntary or as a result of
acceleration, an amount equal to the product of (i) the excess, if any, of the rate of interest on the principal amount so prepaid over the rate of interest on debt securities issued by the
Treasury of the United States of America on a date approximating the date 

4

 

of payment of such principal amount and having a maturity date approximating the last Banking Day of the applicable LIBOR Period, multiplied by (ii) the principal amount so prepaid, multiplied
by (iii) a fraction, the numerator of which is the number of days remaining in the related LIBOR Period and the denominator of which is 360. 

        LIBOR Rate.    With respect to any LIBOR Portion for the related LIBOR Period, an interest rate per annum (rounded upwards, if
necessary, to the next higher 1/8 of 1%) equal to the product of (a) the Base LIBOR Rate (as hereinafter defined) and (b) Statutory Reserves. For purposes of this definition, the term
"Base LIBOR Rate" shall mean the rate (rounded to the nearest 1/8 of 1% or, if there is no nearest 1/8 of 1%, the next higher 1/8 of 1%) at which
deposits of U.S. dollars approximately equal in principal amount to the LIBOR Portion and for a maturity equal to the applicable LIBOR Period are offered to the Bank in the London interbank foreign
currency deposits market at approximately 11:00 a.m., London time, two (2) Banking Days prior to the commencement of such LIBOR Period, for delivery on the first day of such LIBOR
Period. Each determination by the Bank of any LIBOR Rate shall, in the absence of manifest error, be conclusive, and at the Company's request, the Bank shall demonstrate the basis for such
determination. 

        LIBOR Request.    Notice in writing (or by telephonic communications confirmed by telex, telecopy or other facsimile
transmission on the same day as the telephone request) from the Company to the Bank requesting that interest on a LIBOR Portion be based on the LIBOR Rate, specifying: (i) the first day of the
LIBOR Period, (ii) the length of the LIBOR Period consistent with the definition of that term and (iii) a dollar amount of the LIBOR Portion consistent with the definition of that term. 

        Statutory Reserves.    A fraction, the numerator of which is the number one and the denominator of which is the number one minus
the aggregate of the maximum reserve percentages (including, without limitation, any marginal, special, emergency or supplemental reserves), expressed as a decimal, established by the Board and any
other banking authority to which the Bank is subject for Eurocurrency Liabilities (as defined in Regulation D of the Board). Such reserve percentages shall include, without limitation, those
imposed under such Regulation D. LIBOR Portions of the Loans shall be deemed to constitute Eurocurrency Liabilities and as such shall be deemed to be subject to such reserve requirements
without benefit of or credit for proration, exceptions or offsets which may be available from time to time to the Bank under such Regulation D. Statutory Reserves shall be adjusted
automatically on and as of the effective date of any change in any reserve percentage. 

        Tax.    In relation to any LIBOR Portion and the applicable LIBOR Rate, any tax, levy, impost, duty, deduction, withholding or
other charges of whatever nature required by any Legal Requirement (i) to be paid by the Bank and/or (ii) to be withheld or deducted from any payment otherwise required hereby to be made
by the Company to the Bank, provided that the term "Tax" shall not include any taxes imposed upon the net income of the Bank by the United States of
America or any political subdivision thereof (including state and local governmental authorities). 

        (d)  Additions to Section 2 of the Loan Agreement.    Sections 2.9A, 2.9B, 2.9C, and 2.9D of the Loan
Agreement as set forth below are hereby added to the Loan Agreement immediately following Section 2.9: 

        2.9A    Conditions for Basing Interest on the LIBOR Rate.    Upon the condition that: 

        (a)  The
Bank shall have received a LIBOR Request from the Company prior to noon at least three (3) Banking Days prior to the first day of the LIBOR Period requested; 

5

 

        (b)  There
shall have occurred no change in applicable law which would make it unlawful for the Bank to obtain deposits of U.S. dollars in the London interbank foreign
currency deposits market; 

        (c)  As
of the date of the LIBOR Request and the first day of the LIBOR Period, there shall exist no Event of Default, nor any Default, which has not been waived by the Bank; 

        (d)  The
Bank shall not have determined in good faith that it is unable to determine the LIBOR Rate in respect of the requested LIBOR Period or that it is unable to obtain
deposits of U.S. dollars in the London interbank foreign currency deposits market in the applicable amounts and for the requested LIBOR Period; and 

        (e)  As
of the first date of the LIBOR Period specified in such LIBOR Request, and after having given effect thereto, there shall be no more than an aggregate of five
(5) LIBOR Portions outstanding; 

then
interest on the LIBOR Portion requested during the LIBOR Period requested will be at the applicable LIBOR Rate. 

        2.9B Indemnification for Funding and Other Losses.    Each LIBOR Request shall be irrevocable and binding on the
Company. Without limiting the generality of Section 2.9C, the Company shall indemnify the Bank against any loss or expense incurred by the Bank as a result of any failure on the part of the
Company to fulfill, on or before the date specified in any LIBOR Request, the applicable conditions set forth in this Agreement, including, without limitation, any loss (including loss of anticipated
profits) or expense incurred by reason of the liquidation or redeployment of deposits or other funds acquired by the Bank to fund or maintain the requested LIBOR Portion when interest on such LIBOR
Portion, as a result of such failure on the part of the Company, is not based on the applicable LIBOR for the requested LIBOR Period. The Bank shall determine the amount of such loss or expense
incurred by it, and absent manifest error such determination shall be conclusive, and at the Company's request the Bank shall demonstrate the basis for such determination. 

        2.9C     Change in Applicable Laws, Regulations, etc.    If any Legal Requirement shall make it unlawful
for the Bank to fund through the purchase of U.S. dollar deposits any LIBOR Portion, or otherwise to give effect to its obligations as contemplated hereby, or shall impose on the Bank any costs based
on or measured by the excess above a specified level of the amount of a category of deposits or other liabilities of the Bank, which includes deposits by reference to which the LIBOR Rate is
determined as provided herein or a category of extensions of credit or other assets of the Bank which includes any LIBOR Portion, or shall impose on the Bank any restrictions on the amount of such a
category of liabilities or assets which the Bank may hold, (a) the Bank may by notice thereof to the Company terminate the LIBOR Option, (b) any LIBOR Portion subject thereto shall
immediately bear interest thereafter at the rate provided for in Section 2.8(a) or (b), as applicable, and (c) the Company shall indemnify the Bank against any loss, penalty or expense
incurred by the Bank by reason of the liquidation or redeployment of deposits or other funds acquired by the Bank to fund or maintain such LIBOR Portion, as provided in Section 2.9B. 

        2.9D    Taxes.    It is the understanding of the Company and the Bank that the Bank shall receive
payments of amounts of principal of and interest on the Loans with respect to the LIBOR Portions from time to time subject to a LIBOR Option free and clear of, and without deduction for, any Taxes. If
(a) the Bank shall be subject to any such Tax in respect of any such LIBOR Portion or part thereof or (b) the Company shall be required to withhold or deduct any such Tax from any such
amount, and (c) such Tax shall not have existed as of the date of the applicable LIBOR Request, the LIBOR applicable to such LIBOR Portion shall be adjusted by the Bank to reflect all
additional costs incurred by the Bank in connection with the payment by the Bank or 

6

 

the withholding by the Company of such Tax and the Company shall provide the Bank with a statement detailing the amount of any such Tax actually paid by the Company. Determination by the Bank of the
amount of such costs shall, in the absence of manifest error, be conclusive, and at the Company's request, the Bank shall demonstrate the basis of such determination. If after any such adjustment, any
part of any Tax paid by any Bank is subsequently recovered by the Bank, the Bank shall reimburse the Company to the extent of the amount so recovered. A certificate of an officer of the Bank setting
forth the amount of such recovery and the basis therefor shall, in the absence of manifest error, be conclusive. 

        (e)  Modifications to Sections 2A.

            i.  Section 2A.1(b)
of the Credit Agreement is hereby modified to delete the reference to Section 2A.7 from such Section and replace it with a reference to
Section 2.8. 

          ii.  Section 2A.1(c)
of the Credit Agreement is hereby modified to delete the reference to Section 2A.9 from such Section and replace it with a reference to
Section 2.9A. 

          iii.  Section 2A.6(a)
of the Credit Agreement is hereby modified to delete the reference to Section 2A.7 from such Section and replace it with a reference to
Section 2.8. 

          iv.  Sections
2A.7, 2A.8, 2A.9, 2A.10. 2A.11, and 2A.12 of the Loan Agreement are hereby deleted. 

        (f)    Addition of Section 2B of the Loan Agreement.    Section 2B of the Loan Agreement as set forth
below is hereby added to the Loan Agreement immediately following Section 2:- 

SECTION 2B

DESCRIPTION OF EQUIPMENT LOANS II  

        2B.1 The Equipment Loans II.

        (a)  General Provisions.    Upon the terms and subject to the conditions of set forth in the Third Amendment
Agreement, and in reliance upon the representations, warranties and covenants of the Company made herein and therein, the Bank agrees, during the Equipment Loan II Availability Period, to make one or
more equipment loans (the "Equipment Loans II") to the Company, for the purpose of financing the acquisition of capital and laboratory equipment,
including, without limitation, software; provided that (1) the aggregate principal amount of Equipment Loans II advanced by the Bank to the
Company shall not exceed the Equipment Loan II Commitment Amount, and (2) no Equipment Loan II shall be less than $250,000; provided that in
addition to any requested Equipment Loans II in the principal amount of $250,000 or more, not more often than once during each fiscal quarter of the Company, the Company may request an Equipment Loan
II in the principal amount of not less than $5,000, and (3) at the time the Company requests an Equipment Loan II and after giving effect to the making thereof there has not occurred and is not
continuing any Default or Event of Default. Equipment Loans II which are repaid may not be reborrowed. 

        (b)  Equipment Note II.    The Equipment Loans II shall be evidenced by an Equipment Note II, in the
form attached hereto as Exhibit G, payable to the order of the Bank in the original principal amount of $1,500,000. The Equipment Note II
shall be dated the date of the Third Amendment Agreement and shall have the blanks therein appropriately filled in. The Equipment Note II shall bear interest at the rate or rates, and such
interest shall be payable on the dates, specified in Section 2.8. 

        (c)  Notices of Borrowing.    Prior to 12:00 noon (Boston time) one Business Day prior to the proposed Equipment
Loan II request date, an Authorized Officer shall submit to the Bank a 

7

 

Notice of Borrowing, with the proposed date of borrowing and the principal amount requested; provided that with respect to any Equipment Loan II with interest based on the LIBOR Rate, the conditions
of Section 2.9A shall also be satisfied. No Notice of Borrowing shall be revocable by the Company. 

        (d)  Invoices; Limitation on Equipment Loan Advances.

            i.  At
the time of the delivery of a Notice of Borrowing for an Equipment Loan II hereunder and as a condition to such Equipment Loan II, the Company shall deliver to the
Bank invoices, in form and substance satisfactory to the Bank, for the equipment to be financed with such Equipment Loan II, which invoices shall be dated no more than 90 days prior to the date
of the requested Equipment Loan II; provided that on the date of the closing of the Third Amendment Agreement, the Company may include equipment with invoices dated no earlier than March 31,
2002. 

          ii.  No
Equipment Loan II shall exceed 90% of the purchase price of the equipment to be financed therewith (exclusive of soft costs and the costs of any delivery,
installation, brokerage or maintenance fees and any taxes) as set forth on such invoices. 

        2B.2 Loan Account; Notations.

        (a)  The
Bank shall enter the Equipment Loans II as debits in the Loan Account. The Bank shall also record in the Loan Account all payments made by the Company on account of
the Equipment Loans II, and may also record therein, in accordance with customary accounting practices, other debits and credits, and all interest, fees, charges and expenses related to the Equipment
Loan II chargeable to the Company under this Agreement. The debit balance of the Loan Account shall reflect the amount of the Company's Obligations to the Bank from time to time by reason of the
Equipment Loan II and other appropriate charges hereunder. Periodically, the Bank shall render a statement of account showing as of the date of such statement the debit balance of the Loan Account
with respect to the Equipment Loan II which, unless notice to the contrary is received by the Bank from the Company within thirty (30) days of such date, and absent manifest error, shall be
considered correct and accepted by the Company and conclusively binding upon it. 

        (b)  The
Bank shall, and is hereby irrevocably authorized by the Company to, enter on the schedule forming a part of the Equipment Note II or otherwise in its records
appropriate notations evidencing the date and the amount of the Equipment Loans II, the interest rate applicable thereto and the date and amount of each payment of principal made by the Company with
respect thereto; and in the absence of manifest error, such notations shall constitute conclusive evidence thereof. The Bank is hereby irrevocably authorized by the Company to attach to and make a
part of the Equipment Note II a continuation of any such schedule as and when required. No failure on the part of the Bank to make
any notation as provided in this subsection (b) shall in any way affect the Equipment Loan II or the rights or obligations of the Bank or the Company with respect thereto. 

        2B.3 Advances.    Subject to the terms and conditions of this Agreement, the Bank shall make an Equipment Loan II
on the disbursement date specified therefor in a Notice of Borrowing by crediting the amount of the Equipment Loan II to the Company's demand deposit account with the Bank or as otherwise instructed
in writing by the Company. 

        2B.4 Prepayments and Payments of the Equipment Loans II.    (a) The Company shall not have any right to
prepay the principal amount of any Equipment Loan II other than as provided in this Section 2B.4. 

8

 

        (b)  On
at least one (1) Business Day prior written notice to the Bank, with respect to Equipment Loans II based on the Prime Rate, and three (3) Business Days
prior written notice to the Bank, with respect to any LIBOR Portion, the Company may, at its option, prepay the Equipment Loans II, in whole at any time or in part from time to time, without penalty
or premium; provided, that any prepayment of any LIBOR Portion shall be made together with the applicable LIBOR Premium. Any interest accrued on the
amounts so prepaid to the date of such payment must be paid at the time of any such payment. Any optional prepayment of the Equipment Loans II shall be applied to installments of principal payable on
the Equipment Loans II in the inverse order of maturity. 

        (c)  Commencing
on March 31, 2004, the Company hereby unconditionally promises to pay to the Bank quarterly principal payments on the Equipment Loans II on the last
Business Day of each calendar quarter in an amount equal to the amount of principal which would amortize the principal amount of the Equipment Loans II outstanding on December 31, 2003 in eight
equal installments. 

        (d)  To
the extent not previously paid, all unpaid principal and accrued interest on the Equipment Loans II shall be due and payable in full on the Equipment Loan II Maturity
Date. 

        2B.5 Method of Payment.    All payments and prepayments of principal and all payments of interest on the Equipment
Loans II shall be made by the Company to the Bank at 100 Federal Street, Boston, Massachusetts 02110, in immediately available funds, on or before 11:00 a.m. on the due date thereof, free and
clear of, and without any deduction or withholding for, any taxes or other payments. The Bank may, and the Company hereby authorizes the Bank to, debit the amount of any payment not made by such time
to the demand deposit account of the Company with the Bank. 

        2B.6 Interest upon an Event of Default; Overdue Payments.    (a) Upon the occurrence and during the
continuance of an Event of Default, interest on the outstanding principal amount of the Equipment Note II and (to the extent permitted by law) on accrued but unpaid interest shall thereafter be
payable on demand at a rate per annum equal to two percent (2%) above the interest rate otherwise in effect with respect to such Equipment Loan II. Upon the cure of an Event of Default and the payment
of interest at the default rate through the date of such cure, the interest rate shall revert to that provided for in Section 2.8. 

        (b)  If
a payment of principal or interest on the Equipment Loans II hereunder is not made in full within 10 days of date when due, the Company will pay to the Bank a
late fee equal to five percent (5%) of the amount of such payment. Nothing in the preceding sentence shall affect the Bank's right to exercise any of its rights or remedies, including those provided
in Section 8.2, if an Event of Default has occurred. 

        (g)  Amendment to Section 4.    Section 4.13 is hereby amended by deleting subsection (b) and
replacing it with the following subsections (b) and (c): 

        (b)  The
proceeds of the Equipment Loans shall be used exclusively for the purpose of financing the acquisition of capital and laboratory equipment, including, without
limitation, software and leasehold improvements. The proceeds of the Equipment Loans II shall be used exclusively for the purpose of financing the acquisition of capital and laboratory equipment,
including, without limitation, software. The Company may use the initial Equipment Loans II (to be advanced on or before January 31, 2003) to finance equipment previously acquired by the
Company under invoices dated no earlier than March 31, 2002. 

        (c)  The
proceeds of the Term Loan shall be used exclusively for the purpose of refinancing of existing Indebtedness. 

9

 

        (h)  Amendments to Section 5.

            i.  Section 5.1(b1)
is hereby amended by inserting the following immediately before the first word in such section: 

        "at
any time when the Company's Cash Equivalent Amount shall not be greater than $25,000,000," 

          ii.  Section 5.1(d)
is hereby deleted and replaced by the following: 

        (d)  concurrently
with the delivery of each financial statement of the Company pursuant to subsections 5.1(a), 5.1(b) and 5.1(b1) and at any time reasonably requested by the
Bank, a completed compliance certificate substantially in the form of Exhibit C hereto signed on behalf of the Company by an Authorized Officer; 

          iii.  Section 5.1(e)
is hereby deleted and replaced by the following: 

        (e)  concurrently
with the delivery of each financial statement pursuant to subsection (a), projections for the Company and its Subsidiaries on a consolidating and
consolidated basis for the current fiscal year, including projected balance sheets, income statements, cash flow statements and such other statements as the Bank may reasonably request and in form and
substance satisfactory to the Bank, all prepared in good faith and based on assumptions which were reasonable when made; 

          iv.  Sections
5.10, 5.11 and 5.12 of the Loan Agreement are hereby deleted and replaced by the following provisions: 

        5.10 Minimum Liquidity Ratio.    The Company shall maintain at all times a Cash Equivalent Amount equal to or
greater than 150% of its Total Liabilities. 

        5.11 Minimum Tangible Capital Base.    The Company shall maintain at all times a Tangible Capital Base of not less
than $40,000,000. 

        5.12 Minimum Debt Service Coverage Ratio/Minimum Cash or Equivalents.    The Company shall maintain at all times
(a) a Debt Service Coverage Ratio of not less than 1.50 to 1.00, or (b) a Cash Equivalent Amount equal to or greater than the greatest of: (i) $10,000,000, (ii) 200% of the
Funded Senior Indebtedness, (iii) the Annualized Cash Burn; and (iv) the projected Cash Burn for the period of four consecutive fiscal quarters immediately succeeding such date of
determination. 

          v.  The
following Section 5.13 is hereby added to the Loan Agreement: 

        5.13 Subsidiary Guarantees.    In the event that the Borrower or any of its Subsidiaries shall form or acquire any
new domestic Subsidiary after the date hereof (or became the subsidiary of a holding company), as applicable, the Borrower or such Subsidiary will cause such new Subsidiary (or holding company) within
five Business Days after such formation or acquisition to execute and deliver to the Bank a guaranty agreement, satisfactory in form and substance to the Bank, guarantying all the Loans and other
obligations of the Borrower hereunder and under the other Loan Documents. 

        (i)    Amendments to Section 6.

            i.  Section 6.6
is hereby deleted and replaced by the following: 

        6.6.  Merger; Consolidation; Sale or Lease of Assets.    Neither the Company nor any of its Subsidiaries shall,
without the prior written consent of the Bank, sell, lease or otherwise dispose of assets or properties, other than sales or leases of inventory in the ordinary course of business; or liquidate, merge
or consolidate into or with or acquire any other Person or entity, provided that any Subsidiary of the Company may merge or consolidate into or with
(i) the Company if no 

10

 

Default or Event of Default has occurred and is continuing or would result from such merger and if the Company is the surviving company or (ii) any other wholly-owned Subsidiary of the
Company; provided further, that the Company may acquire all or substantially all of the assets or the capital stock of, or other equity interests in
Biosearch Italia, or Biosearch Italia may be merged with or into the Company (the "BI Acquisition"), subject to satisfaction of the following conditions: 

        (a)  immediately
prior to the BI Acquisition and after giving effect thereto, no Default or Event of Default shall have occurred and be continuing or will arise on a  pro forma basis and the Company shall have provided
the Bank evidence satisfactory to it, in its sole discretion, to such effect (including, without
limitation, a compliance certificate demonstrating pro forma compliance with the financial covenants contained in Sections 5.10, 5.11 and 5.12); 

        (b)  if
the BI Acquisition is consummated (i) by way of merger or consolidation, the Company shall be the surviving entity, or (ii) by way of asset sale, the
assets so acquired shall be transferred free and clear of any Encumbrances (except to the extent permitted by Section 6.4), or (iii) by way of acquisition in which Biosearch Italia
becomes a domestic Subsidiary of the Company, or the Company forms a domestic Subsidiary for the purpose of acquiring the assets of Biosearch Italia, the Bank shall have received a Guaranty Agreement
in the form of Exhibit J attached hereto executed by Biosearch Italia or such newly-formed domestic Subsidiary; 

        (c)  no
Indebtedness in excess of $2,000,000 shall be incurred, guaranteed, assumed or consolidated in connection with the BI Acquisition (except to the extent permitted by
Section 6.1); 

        (d)  the
Bank shall have received lien searches reasonably satisfactory to the Bank with respect to the assets of, and equity interests in, Biosearch Italia; 

        (e)  the
representations and warranties of the Company set forth in Section 4 shall be true and correct on the date of the BI Acquisition as if made on such date
(except to the extent that such representations and warranties expressly relate to an earlier date), after giving effect to the BI Acquisition on a pro
forma basis; 

        (f)    to
the extent any representation or warranty herein makes reference to one or more of the schedules to this Agreement, and as result of the BI Acquisition a new schedule
should be created, the Company shall create, or make revisions to such schedules, in each case as of the date of the consummation of the BI Acquisition and notwithstanding that such representation or
warranty may expressly state that it is made as of an earlier date, reasonably acceptable to the Bank, solely to take into account the consummation of the BI Acquisition; 

        (g)  the
Bank shall have received copies of the merger agreement pursuant to which the BI Acquisition will be consummated; and 

        (h)  the
Bank shall have received any other information reasonably requested by the Bank with respect to the BI Acquisition. 

          iii.  Addition of Section 6.13 of the Loan Agreement.    Section 6.13 of the Loan Agreement as set
forth below is hereby added to the Loan Agreement immediately following Section 6.12: 

        6.13 Restrictive Agreements.    The Company will not, directly or indirectly, enter into, incur or permit to exist
any agreement or other arrangement that prohibits, restricts or imposes any condition upon the ability of the Company to create, incur or permit to exist any Encumbrance upon any of its property or
assets, or provided that the foregoing shall not apply to (a) restrictions and conditions imposed by law or by this Agreement,
(b) restrictions and conditions existing on the date hereof identified on Schedule 6.13 (but shall apply to any extension or renewal of, or any amendment or modification expanding the
scope of, any such restriction or condition), (c) restrictions or conditions imposed by any agreement relating to secured Indebtedness permitted 

11

 

by this Agreement if such restrictions or conditions apply only to the property or assets securing such Indebtedness, (d) customary provisions in leases, license agreements and other contracts
now existing or hereafter entered into restricting the assignment thereof. 

        (j)    Amendment to Exhibit C.    Exhibit C is replaced by Exhibit C attached hereto. 

        3.    No Default; Representations and Warranties, etc.

        The
Company hereby confirms that: (a) except as set forth on the Disclosure Schedule attached hereto, the representations and warranties of the Company contained in
Section 4 of the Loan Agreement are true on and as of the date hereof as if made on such date (except to the extent that such representations and warranties expressly relate to an earlier
date); (b) the Company is in compliance in all material respects with all of the terms and provisions set forth in the Loan Agreement on its part to be observed or performed thereunder; and
(c) after giving effect to this Amendment Agreement, no Event of Default specified in Section 8 of the Loan Agreement, nor any event which with the giving of notice or expiration of any
applicable grace period or both would constitute such an Event of Default, shall have occurred and be continuing. 

        4.    Conditions to the Effectiveness of this Amendment Agreement.

        Concurrently
herewith (and as conditions to the Bank's consent to this Amendment Agreement), the Company will furnish the Bank with the following: 

        (a)  This
Amendment Agreement duly executed by the Company; 

        (b)  The
Term Note duly executed by the Company; 

        (c)  The
Equipment Note II duly executed by the Company; 

        (d)  A
Perfection Certificate in the form of Exhibit H duly completed and executed by the Company; 

        (e)  A
Pledged Account Agreement in the form of Exhibit I attached hereto executed by the Company to perfect the Bank's
security interest in the collateral described therein; 

        (f)    A
certificate of the Secretary or an Assistant Secretary of the Company certifying: (i) the resolutions of the Company's board of directors authorizing the
execution and delivery of this Amendment Agreement, the Equipment Note II, (ii) the identity of the officer(s) authorized to execute, deliver and take all other actions required under
this Amendment Agreement, and the specimen signatures of such officers, (iii) the true, correct and complete copy of the certificate of incorporation of the Company
(together with all amendments thereto), and (iv) the true, correct and complete copy of the Bylaws of the Company (together with all amendments thereto); 

        (g)  A
certificate of the Secretary of State of the State of Delaware, as to legal existence and good corporate standing of the Company in such state and listing all
documents on file in the office of said Secretary of State; 

        (h)  A
certificate of the Secretary of State of the State of California, as to the qualification of the Company to transact business in such state; 

        (i)    A
certificate of the Secretary of the Commonwealth of Pennsylvania, as to the qualification of the Company to transact business in such commonwealth; 

        (j)    Lien
searches against the Company in all appropriate jurisdictions; 

        (k)  A
landlord's consent and estoppel with respect to the Company's leasehold properties located in Fremont, California and King of Prussia, Pennsylvania, each in a form
satisfactory to the Bank and its counsel; 

12

 

        (l)    The
Bank's security interest in the Collateral (as defined in Section 7.1 as amended by this Amendment Agreement) shall continue to be a first priority perfected
security interest subject only to Permitted Encumbrances and such UCC-1 financing statements or UCC-3 continuation statements as may be necessary to maintain such first
priority perfected security interest shall have been filed in all appropriate filing offices; 

        (m)  Opinion
of O'Melveney & Myers LLP, reasonably acceptable in form and substance to the Bank and its counsel; 

        (n)  Payment
of the $50,000 facility fee by the Company to the Bank; 

        (o)  Payment
of all invoiced fees and expenses (including legal fees and disbursements) incurred by the Bank in connection with this Amendment Agreement and the transactions
contemplated hereby; and 

        (p)  Such
other documents and instruments as the Bank may reasonably require in order to put this Amendment Agreement into full force and effect. 

        5.    Miscellaneous.

        (a)  Except
to the extent specifically amended hereby, the Loan Agreement, Loan Documents and all related documents shall remain in full force and effect. Whenever the terms
or sections amended hereby shall be referred to in the Loan Agreement, the Loan Documents or such other documents (whether directly or by incorporation into other defined terms), such defined terms
shall be deemed to refer to those terms or sections as amended by this Amendment Agreement. All references in the Loan Agreement, Loan Documents or such other documents to the Notes shall be deemed to
refer to the Term Note, the Equipment Note and the Equipment Note II. 

        (b)  This
Amendment Agreement may be executed in any number of counterparts, each of which, when executed and delivered, shall be an original, but all counterparts shall
together constitute one instrument. 

        (c)  The
Company shall pay all reasonable expenses, including reasonable legal fees and disbursements incurred by the Bank in connection with this Amendment Agreement and the
transactions contemplated hereby and any other expenses, reasonable legal fees and disbursements incurred by the Bank. 

        (d)  This
Amendment Agreement shall be governed by the laws of the Commonwealth of Massachusetts and shall be binding upon and inure to the benefit of the parties hereto and
their respective successors and assigns. 

[The
remainder of this page is intentionally left blank.] 

13

 

        IN
WITNESS WHEREOF, the parties hereto have executed this Amendment Agreement which shall be deemed to be a sealed instrument as of the date first above written. 

	 	 	VERSICOR INC.
	

 	
 	

By:	
 	

/s/  DOV GOLDSTEIN      
 Name: Dov A. Goldstein, M.D.

Title: VP, Finance & CFO
	

 	
 	

FLEET NATIONAL BANK
	

 	
 	

By:	
 	

/s/  KIMBERLY MARTONE      
 Name: Kimberly Martone

Title: Managing Director

14

QuickLinks

Exhibit 10.12.3

THIRD AMENDMENT AGREEMENT TO TERM LOAN

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