Document:

EX-10.1

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT

THIS FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Agreement”) is dated as of August
27, 2012, by and among EPICEPT CORPORATION, a Delaware corporation (“EpiCept”), MAXIM
PHARMACEUTICALS INC., a Delaware corporation (“Maxim”), CYTOVIA, INC., a Delaware corporation
(“Cytovia”, and collectively with EpiCept and Maxim, the “Borrowers”), MIDCAP FUNDING III, LLC, a
Delaware limited liability company in its capacity as agent (“Agent”) for the lenders under the
Loan Agreement (as defined below) (“Lenders”), and the Lenders.

W I T N E S S E T H:

WHEREAS, Borrowers, Lenders and Agent are parties to that certain Loan and Security Agreement,
dated as of May 27, 2011 (as amended, restated, supplemented or otherwise modified from time to
time, the “Loan Agreement”; capitalized terms used herein have the meanings given to them in the
Loan Agreement except as otherwise expressly defined herein), pursuant to which Lenders have agreed
to provide to Borrowers certain loans and other extensions of credit in accordance with the terms
and conditions thereof; and

WHEREAS, the Borrowers have requested that the Agent and Lenders amend the Loan Agreement in
certain respects and the undersigned Lenders and the Agent are willing to make such amendment, all
in accordance with, and subject to, the terms and conditions set forth in, this Agreement.

NOW, THEREFORE, in consideration of the premises, the covenants and agreements contained
herein, and other good and valuable consideration, the receipt and adequacy of which are hereby
acknowledged, Borrowers, Lenders and Agent hereby agree as follows:

1. Acknowledgment of Obligations. Each Borrower acknowledges and agrees that as of
the First Amendment Effective Date, but without giving effect to this Agreement, the aggregate
principal balance of the Term Loan is at least $5,270,967.80. The foregoing amount does not
include interest, fees, expense and other amounts that are chargeable or otherwise reimbursable
under the Loan Agreement and the other Loan Documents. Borrowers hereby acknowledge, confirm and
agree that all Term Loans made prior to the date hereof, together with interest accrued and
accruing thereon, and fees, costs, expenses and other charges owing by Borrowers to Agent and
Lenders under the Loan Agreement and the other Loan Documents, are unconditionally owing by
Borrowers to Agent and Lenders, without offset, defense or counterclaim of any kind, nature or
description whatsoever except as may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium or other similar laws relating to or affecting creditor’s rights
generally.

2. Amendments to the Loan Agreement. Subject to the terms and conditions of this
Agreement, including without limitation fulfillment of the conditions to effectiveness specified in
Section 8 below, the Loan Agreement is hereby amended as follows:

(a) Section 2.2(b) of the Loan Agreement shall be deleted in its entirety and the following
revised Section 2.2(b) shall be substituted in lieu thereof:

“(b) Interest Payments and Repayment. Commencing on the first (1st)
Payment Date following the Funding Date of Tranche One, and continuing on the Payment Date
of each successive month thereafter through and including the Maturity Date, Borrower shall
make monthly payments of interest to each Lender in accordance with its respective Pro Rata
Share, in arrears, and calculated as set forth in Section 2.3. In addition to the interest
payments in accordance with the immediately preceding sentence, Borrower shall make
principal payments with respect to the Term Loans as follows: (i) commencing on the
Amortization Date, and continuing on the Payment Date of each successive month thereafter
through the First Amendment Effective Date, Borrower shall make consecutive monthly payments
of principal to each Lender in accordance with its respective Pro Rata Share, as calculated
by Agent based upon: (A) the amount of such Lender’s Term Loans and (B) a straight-line
amortization schedule ending on the Maturity Date, (ii) on the First Amendment Effective
Date, Borrower shall make a principal payment of $1,200,000.00, which payment shall be
allocated and paid to each Lender in accordance with its Pro Rata Share, (iii) on January
15, 2013, and on each Payment Date thereafter beginning with February 1, 2013 through the
Maturity Date, Borrower shall make principal payments of $277,419.35 on each such date,
which payment shall be allocated and paid to each Lender in accordance with its Pro Rata
Share and (iv) Borrower shall pay the remaining outstanding balance of the Term Loan on the
Maturity Date. Without limiting the foregoing, all unpaid principal and accrued interest
with respect to the Term Loans is due and payable in full on the Maturity Date. The Term
Loans may be prepaid only in accordance with Sections 2.2(c) and 2.2(d).”

(b) Section 14 of the Loan Agreement shall be amended by adding thereto in appropriate
alphabetical order the following definition:

“‘First Amendment Effective Date’ has the meaning given such term in the First Amendment to
Loan and Security Agreement, dated as of August 27, 2012, among the Borrowers, Agent and
Lenders signatory thereto.”

3. Final Payment Fee. Borrower acknowledges and agrees that, notwithstanding any of
the amendments or other modifications set forth herein or in any other documentation or
correspondence related to the Loan Agreement or Loan Documents, or any other action taken by
Borrower, Agent or any Lender, the Final Payment remains due and payable, in full and without
counterclaim or offset of any kind, on the Maturity Date.

4. Additional Covenants. Until such time as Agent has indicated otherwise in writing,
Borrower agrees as follows:

(a) Pursuit of Acceptable Sale or Partnering Transaction. Borrower shall, and shall
cause each of its agents, representatives, officers, directors, employees and advisors, to use its
best efforts to (i) negotiate and enter into a definitive agreement with respect to an Acceptable
Sale or Partnering Transaction (as defined below) as soon as practical but in any event no later
than October 15, 2012 and (ii) consummate such Acceptable Sale or Partnering Transaction as soon as
practical but in any event no later than January 15, 2013. An “Acceptable Sale or Partnering
Transaction” shall mean (i) a sale, merger or similar transaction with respect to Borrower and/or
(ii) a partnering transaction in connection with the Borrower’s drug AmiKet (formerly known as
EpiCept NP-1), in the case of either or both clause (i) and (ii) on terms and conditions and
subject to documentation satisfactory to Agent in its sole discretion, which either (x) provides
for the payment in full of the Obligations by not later than January 15, 2013 or (y) provides for
the Loans and Loan Documents to remain outstanding on terms and conditions and pursuant to
documentation satisfactory to Agent in its sole discretion; provided, that, nothing in this
Agreement shall constitute Agent’s or any Lender’s consent to any such transaction or any
documentation entered into in connection with any such transaction, all of which remains subject to
future consent by Agent and the Lenders.

(b) Cooperation and Deliverables Relating to Acceptable Sale or Partnering
Transaction. Borrower shall deliver to Agent on the first Business Day of each week an
officer’s certificate, in form and substance satisfactory to Agent, executed by Borrower’s Chief
Financial Officer, that includes (i) a status update and detailed summary with respect to (A) any
potential or ongoing partnering transactions in connection with the Borrower’s drug AmiKet
(formerly known as EpiCept NP-1), and (B) any transaction or potential transaction with respect to
a sale or merger involving the Borrower, in all cases under clause (A) or (B), whether or not the
same would constitute an Acceptable Sale or Partnering Transaction and (ii) a certification by
Borrower’s Chief Financial Officer, that there have been no adverse changes in connection with
discussions, negotiations and circumstances surrounding any such potential transaction, including
any circumstances that would either (A) cause such transaction not to constitute an Acceptable Sale
or Partnering Transaction or (B) affect in any way the possibility that such transaction is
documented by not later than October 15, 2012 or consummated by not later than January 15, 2013.
Borrower shall, at the request of Agent, cause all officers, management personnel or other
representatives of Borrower (as requested by Agent) to make themselves available to participate in
a telephonic or in person meeting to discuss such weekly status update and any such potential
transaction.

(c) Budget Matters. Borrower shall (i) (A) on or prior to the First Amendment
Effective Date, deliver to Agent an operating budget in form, substance and methodology
satisfactory to Agent, which shall reflect Borrower’s good faith projection of all cash receipts
and disbursements on a week-by-week basis in connection with the operating of its business through
October 31, 2012, (B) for each month (each a “Subject Month”) beginning with the month ending
November 30, 2012 and continuing for each month ended thereafter, on or prior to the date that is
ten (10) days prior to the beginning of such Subject Month, deliver to Agent an operating budget in
form, substance and methodology satisfactory to Agent, which shall reflect Borrower’s good faith
projection of all cash receipts and disbursements on a week-by-week basis in connection with the
operating of its business for, and through the end of, the Subject Month (the budgets delivered
pursuant to clauses (A) and (B) of this Section 4(c)(i) shall be collectively referred to
as the “Budget”) and (C) on Monday of each week following the First Amendment Effective Date,
deliver to Agent an expense report for the immediately preceding week along with a comparison
against the budget amount of expenses for that week in accordance with the Budget, and (ii) during
any given week, cause its expenditures to be in line with its Budget for such week in all material
respects and, in furtherance of the foregoing, with respect to line items in the Budget in excess
of $25,000, shall not make expenditures with respect to any line item on the Budget in excess of
five percent (5.0%) (or such greater percentage as may be consented to in writing in advance by
Agent in its sole discretion (the determination of whether Agent is willing to grant such consent
not to be unreasonably delayed)) of the amount set forth on the Budget for such expenditure.

(d) Cash Management. Without limiting the requirements in the Loan Agreement with
respect to Borrower’s Collateral Accounts or otherwise:

	 	(i)	 	On or prior to the First Amendment Effective Date (and
thereafter with respect to any new Receipts (as defined below), Borrower shall
deposit with Agent all of its cash, Cash Equivalents and other items of payment
or receipts (such cash, Cash Equivalents and other items of payment or
receipts, collectively, the “Receipts”) to be held by Agent subject to
distribution into the Specified Controlled Operating Account or the Specified
Controlled Deposit Account as set forth below.

	 	(ii)	 	By not later than August 31, 2012, Borrower shall establish or
designate a deposit account in the name of Borrower (the “Specified Controlled
Operating Account”) with a depositary institution satisfactory to Agent and
shall have entered into and caused such depositary institution to enter into a
Control Agreement with Agent that governs such Specified Controlled Operating
Account, which Control Agreement shall provide that Agent has sole dominion and
control over such Specified Controlled Operating Account and that such
depositary institution shall, after depositary has received notice from Agent,
accept only instructions from Agent, and not Borrower, with respect to the
Specified Controlled Operating Account and any and all Receipts on deposit or
to be deposited therein. Upon satisfaction of the requirements set forth in
the immediately preceding sentence of this subclause (ii) in Agent’s
discretion, Agent shall deposit in the Specified Controlled Operating Account a
deposit of $675,000 (or such lesser amount as may be on deposit with Agent) of
Borrower’s Receipts on deposit with Agent (the “Initial Budget Expense Funds”),
which shall be maintained on deposit in the Specified Controlled Operating
Account except as permitted to be used by Borrower in accordance with
Section 4(d)(v) below. Borrower shall not be permitted to deposit any
other Receipts into the Specified Controlled Operating Account other than the
Specified Funds (as defined below) at such times and for such purposes as are
set forth below.

	 	(iii)	 	On or prior to September 7, 2012, Borrower shall have
established a deposit account (the “Specified Controlled Deposit Account”; and
together with the Specified Controlled Operating Account, collectively, the
“Specified Controlled Accounts”), which shall be separate from the Specified
Controlled Operating Account, with a depositary institution satisfactory to
Agent and shall have entered into and caused such depositary institution to
enter into a Control Agreement with Agent that governs such Specified
Controlled Deposit Account, which Control Agreement shall provide that Agent
has sole dominion and control over such Specified Controlled Deposit Account
and that such depositary institution shall, at all times, accept only
instructions from Agent, and not Borrower, with respect to the Specified
Controlled Deposit Account and any and all Receipts on deposit or to be
deposited therein. Upon satisfaction of the requirements set forth in the
immediately preceding sentence of this subclause (iii) in Agent’s discretion,
Agent shall deposit the remaining balance of Borrower’s Receipts that are on
deposit with the Agent into the Specified Controlled Deposit Account. Borrower
shall cause any and all future Receipts (other than the Specified Funds (as
defined below) used in accordance with the terms of this Agreement) to be
deposited into the Specified Controlled Deposit Account.

	 	(iv)	 	Beginning on the first Business Day of the week ending November
9, 2012 and on the first Business Day of each week thereafter (each such week,
a “Draw Week”), so long as (i) no Default or Event of Default shall have
occurred and (ii) so long as no event or circumstances exist or have arisen
which could reasonably be expected to have a Material Adverse Change, Borrower
may request, once during such Draw Week, up to an additional $200,000 (or such
lesser amount as may be on deposit with Agent) (the “Specified Funds”) to be
transferred from the Specified Controlled Deposit Account to the Specified
Controlled Operating Account to be used solely to reimburse Borrower for
expenses actually incurred and disbursements actually made in accordance with
and as set forth in the Budget for the week ended immediately prior to the Draw
Week. If such Specified Funds are available, following such request and a
determination by Agent in its discretion that such expenses have been incurred
or disbursements made in accordance with the Budget, Agent shall instruct the
depositary bank where the Specified Controlled Deposit Account is located to
transfer the Specified Funds to the Specified Controlled Operating Account. To
the extent that any Specified Funds are not used to satisfy such expenses or
disbursements, Borrower shall cause such excess funds to be deposited back into
the Specified Controlled Deposit Account by the first Business Day of the week
immediately succeeding the Draw Week.

	 	(v)	 	Borrower shall use the Initial Budget Expense Funds and the
Specified Funds solely to satisfy the expenses and disbursements set forth in
the Budget and then only in accordance with the procedures set forth in this
Agreement. Without limiting the foregoing, Borrower agrees that it shall not,
under any circumstances, use any of its Receipts, including without limitation,
the Initial Budget Expense Funds and the Specified Funds, to challenge (A) any
of Agent’s or any Lender’s Liens under the Loan Agreement and other Loan
Documents, (B) any right or remedy Agent or any Lender may have under the Loan
Documents or pursuant to applicable law, or (C) the enforceability of any of
the Loan Documents.

	 	(vi)	 	Borrower hereby authorizes Agent and Lenders to debit any
Specified Controlled Account for payment when due of any and all Obligations,
including without limitation, principal payments, interest payments, fees and
Lenders’ Expenses, due to Agent or any Lender pursuant to the Loan Documents.

(e) General Cooperation and Disclosure. Without limiting anything in clauses (a)
through (d) above or otherwise in this Agreement, Borrower shall, and shall cause its officers,
directors, employees and advisors to, cooperate fully with Agent in furnishing information as and
when reasonably requested by Agent or any other Lender regarding the Collateral, Borrower’s
financial affairs, finances, financial condition, business and operations or any other matters
related to the Borrower or otherwise contemplated in this Agreement. Borrower authorizes Agent to
meet and/or have discussions with any of its officers, directors, employees and advisors from time
to time as reasonably requested by Agent to discuss any matters regarding the Collateral,
Borrower’s or any other Credit Party’s financial affairs, finances, financial condition, business
and operations, or any other matters related to the Borrower or otherwise contemplated in this
Agreement and shall direct and authorize all such persons and entities to fully disclose to Agent
all information reasonably requested by Agent regarding the foregoing. Borrower waives and
releases any such officer, director, employee and advisor from the operation and provisions of any
confidentiality agreement with Borrower, as the case may be, such that such person or entity is not
prohibited from providing any of the foregoing information to Agent or any Lender.

5. Additional Events of Default. Any of the following shall constitute an immediate
Event of Default hereunder and under the Loan Agreement: (a) the failure by Borrower to comply with
any term, condition or covenant set forth in this Agreement, (b) the failure of any representation
or warranty made by Borrower under or in connection with this Agreement to be true, correct and
complete as of the date when made or any other breach of any such representation or warranty, (c)
the repudiation and/or assertion of any defense by any Borrower with respect to this Agreement or
any Loan Document or the pursuit by Borrower or any person related to Borrower against the Agent or
any Indemnified Person, (d) the failure by Borrower to deliver the officer’s certificate set forth
in Section 4(b) of this Agreement, or the failure of such certificate to include the
certifications relating to any possible transaction that could constitute an Acceptable Sale or
Partnering Transaction as required by Section 4(b) of this Agreement or (e) a determination
by Agent in its sole discretion that (i) discussions, negotiations or progress relating to any
potential Acceptable Sale or Partnering Transaction have ceased or slowed or other circumstances or
developments have arisen that make it unlikely that such sale or partnering transaction will be
consummated or (ii) it is unlikely that Borrower shall be able to document or consummate an
Acceptable Sale or Partnering Transaction in a time period acceptable to Agent.

6. No Other Amendments or Consents, Waivers, Etc.; Reservation of Rights. Except for
the amendments and other modifications set forth and referred to in Sections 2 thru
5 above, the Loan Agreement and the other Loan Documents shall remain unchanged and in full
force and effect. Nothing in this Agreement is intended, or shall be construed, to constitute a
novation or an accord and satisfaction of any of Borrowers’ Obligations or to modify, affect or
impair the perfection or continuity of Agent’s security interests in, security titles to or other
liens, for the benefit of itself and the Lenders, on any Collateral for the Obligations. Without
limiting the foregoing, except as expressly set forth herein, the execution, delivery and
effectiveness of this Agreement shall not directly or indirectly (i) create any obligation to make
any further loans, advances or other financial accommodations or to continue to defer any
enforcement action after the occurrence of any Default or Event of Default, whether such Default or
Event of Default has occurred or occurs in the future, (ii) constitute a consent or waiver of any
past, present or future violations of any provisions of the Loan Agreement or any other Loan
Documents nor constitute a novation of any of the Obligations under the Loan Agreement or other
Loan Documents, (iii) amend, modify or operate as a waiver of any provision of the Loan Agreement
or any other Loan Documents or any right, power or remedy of any Lender, (iv) constitute a consent
to any merger or other transaction or to any sale, restructuring or refinancing transaction or (v)
constitute a course of dealing or other basis for altering any Obligations or any other contract or
instrument. Except as expressly set forth herein, each Lender reserves all of its rights, powers,
and remedies under the Loan Agreement, the other Loan Documents and applicable law. All of the
provisions of the Loan Agreement and the other Loan Documents, including, without limitation, the
time of the essence provisions, are hereby reiterated, and if ever waived, are hereby reinstated.

7. Representations and Warranties. To induce Agent and Lenders to enter into this
Agreement, each Borrower does hereby warrant, represent and covenant to Agent and Lenders that (i)
each representation or warranty of Borrowers set forth in the Loan Agreement is hereby restated and
reaffirmed as true and correct in all material respects on and as of the date hereof as if such
representation or warranty were made on and as of the date hereof (except to the extent that any
such representation or warranty expressly relates to a prior specific date or period) and (ii) each
Borrower has the power and is duly authorized to enter into, deliver and perform this Agreement and
this Agreement is the legal, valid and binding obligation of each Borrower enforceable against such
Borrower in accordance with its terms.

8. Condition Precedent to Effectiveness of this Agreement. This Agreement shall
become effective as of the date (the “First Amendment Effective Date”) upon which Agent shall have
received the following, each in form and, in form and substance satisfactory to Agent and Lenders:

(a) one or more counterparts of this Agreement duly executed and delivered by Borrowers, Agent
and Lenders

(b) the principal payment payable on the First Amendment Effective Date as set forth in
Section 2.2(b) of the Loan Agreement (as amended by this Agreement);

(c) satisfaction, in Agent’s sole discretion, by Borrower of all of the conditions set forth
in Section 4 of this Agreement that are required to be satisfied on or prior to the First
Amendment Effective Date; and

(d) such other documents, instruments, agreements and opinions as the Agent shall request.

9. Release.

(a) In consideration of the agreements of Agent and Lenders contained herein and for other
good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, each
Borrower, on behalf of itself and its successors, assigns, and other legal representatives, hereby
absolutely, unconditionally and irrevocably releases, remises and forever discharges Agent and each
Lender and their respective successors and assigns, and their respective present and former
shareholders, affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys,
employees, agents and other representatives (Agent, Lenders and all such other persons being
hereinafter referred to collectively as the “Releasees” and individually as a “Releasee”), of and
from all demands, actions, causes of action, suits, covenants, contracts, controversies,
agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other
claims, counterclaims, defenses, rights of set-off, demands and liabilities whatsoever
(individually, a “Claim” and collectively, “Claims”) of every name and nature, known or unknown,
suspected or unsuspected, both at law and in equity, which any Borrower or any of its successors,
assigns, or other legal representatives may now or hereafter own, hold, have or claim to have
against the Releasees or any of them for, upon, or by reason of any circumstance, action, cause or
thing whatsoever which arises at any time on or prior to the First Amendment Effective Date,
including, without limitation, for or on account of, or in relation to, or in any way in connection
with the Loan Agreement or any of the other Loan Documents or transactions thereunder or related
thereto.

(b) Each Borrower understands, acknowledges and agrees that its release set forth above may be
pleaded as a full and complete defense and may be used as a basis for an injunction against any
action, suit or other proceeding which may be instituted, prosecuted or attempted in breach of the
provisions of such release.

(c) Each Borrower agrees that no fact, event, circumstance, evidence or transaction which
could now be asserted or which may hereafter be discovered shall affect in any manner the final,
absolute and unconditional nature of the release set forth above.

10. Covenant Not To Sue. Each Borrower, on behalf of itself and its successors,
assigns, and other legal representatives, hereby absolutely, unconditionally and irrevocably,
covenants and agrees with and in favor of each Releasee that it will not sue (at law, in equity, in
any regulatory proceeding or otherwise) any Releasee on the basis of any Claim released, remised
and discharged by Borrowers pursuant to Section 9 above. If any Borrower or any of its
successors, assigns or other legal representatives violates the foregoing covenant, Borrowers, for
themselves and their successors, assigns and legal representatives, agree to pay, in addition to
such other damages as any Releasee may sustain as a result of such violation, all attorneys’ fees
and costs incurred by any Releasee as a result of such violation.

11. Indemnification. Borrower hereby agrees to indemnify, defend and hold harmless
Agent and each Lender in accordance with Section 12.2 of the Loan Agreement, the terms of which are
incorporated herein by reference.

12. Advice of Counsel. Each of the parties represents to each other party hereto that
it has discussed this Agreement with its counsel.

13. Severability of Provisions. In case any provision of or obligation under this
Agreement shall be invalid, illegal or unenforceable in any applicable jurisdiction, the validity,
legality and enforceability of the remaining provisions or obligations, or of such provision or
obligation in any other jurisdiction, shall not in any way be affected or impaired thereby.

14. Counterparts. This Agreement may be executed in multiple counterparts, each of
which shall be deemed to be an original and all of which when taken together shall constitute one
and the same instrument.

15. GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE
WITH, THE INTERNAL LAWS OF THE STATE OF MARYLAND APPLICABLE TO CONTRACTS MADE AND PERFORMED IN SUCH
STATE WITHOUT REGARD TO THE PRINCIPLES THEREOF REGARDING CONFLICTS OF LAWS.

16. Entire Agreement. The Loan Agreement and the other Loan Documents as and when
modified through this Agreement embody the entire agreement between the parties hereto relating to
the subject matter thereof and supersede all prior agreements, representations and understandings,
if any, relating to the subject matter thereof.

17. No Strict Construction, Etc. The parties hereto have participated jointly in the
negotiation and drafting of this Agreement. In the event an ambiguity or question of intent or
interpretation arises, this Agreement shall be construed as if drafted jointly by the parties
hereto and no presumption or burden of proof shall arise favoring or disfavoring any party by
virtue of the authorship of any provisions of this Agreement. Time is of the essence for this
Agreement.

18. Loan Document. For the avoidance of doubt, this Agreement constitutes a Loan
Document.

19. Costs and Expenses. Each Borrower absolutely and unconditionally agrees to pay or
reimburse upon demand for all reasonable fees, costs and expenses incurred by Agent and the Lenders
that are Lenders on the Closing Date in connection with the preparation, negotiation, execution and
delivery of this Agreement and any other Loan Documents or other agreements prepared, negotiated,
executed or delivered in connection with this Agreement or transactions contemplated hereby.

[Remainder of page intentionally blank; signature pages follow.]

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed and
delivered as of the day and year specified at the beginning hereof.

BORROWERS:

EPICEPT CORPORATION

By:       

Name:       

Title:       

MAXIM PHARMACEUTICALS INC.

By:       

Name:       

Title:       

CYTOVIA, INC.

By:       

Name:       

Title:       

AGENT AND LENDER:

MIDCAP FUNDING III, LLC

By:       

Name:       

Title: Authorized SignatoryEX-10.1

EXHIBIT 10.1

AMENDMENT NO. 7 TO CONSIGNMENT AGREEMENT

THIS AMENDMENT NO. 7

TO CONSIGNMENT AGREEMENT (this “Amendment”) is made as of August 24, 2012, by and
among CANADIAN IMPERIAL BANK OF COMMERCE, a Canadian chartered bank (the “PM Lender”); CIBC
WORLD MARKETS INC., an Ontario corporation and subsidiary of the PM Lender (the “Copper
Lender” and together with the PM Lender, the “Metal Lenders”); MATERION CORPORATION
(f/k/a Brush Engineered Materials Inc.), an Ohio corporation (“BEM”); MATERION ADVANCED
MATERIALS TECHNOLOGIES AND SERVICES INC. (f/k/a Williams Advanced Materials Inc.), a New York
corporation (“WAM”); MATERION TECHNICAL MATERIALS INC. (f/k/a Technical Materials, Inc.),
an Ohio corporation (“TMI”); MATERION BRUSH INC. (f/k/a Brush Wellman Inc.), an Ohio
corporation (“BWI”); MATERION TECHNOLOGIES INC. (f/k/a Zentrix Technologies Inc.), an
Arizona corporation (“ZTI”); MATERION BREWSTER LLC (f/k/a Williams Acquisition, LLC), a New
York limited liability company d/b/a Pure Tech (“Pure Tech”); MATERION PRECISION OPTICS AND
THIN FILM COATINGS CORPORATION (f/k/a Thin Film Technology, Inc.), a California corporation
(“TFT”); MATERION LARGE AREA COATINGS LLC (f/k/a Techni-Met, LLC), a Delaware limited
liability company (“TML”); MATERION ADVANCED MATERIALS TECHNOLOGIES AND SERVICES CORP.
(f/k/a Academy Corporation), a New Mexico corporation (“AC”); MATERION ADVANCED MATERIALS
TECHNOLOGIES AND SERVICES LLC (f/k/a Academy Gallup, LLC), a New Mexico limited liability company
(“AG”); and such other Subsidiaries of BEM who may from time to time become parties by
means of their execution and delivery with the Metal Lender of a Joinder Agreement under the
Precious Metals Agreement (as defined below). BEM, WAM, TMI, BWI, ZTI, Pure Tech, TFT, TML, AC, AG
and such Subsidiaries are herein sometimes referred to collectively as the “Customers” and
each individually as a “Customer”.

WITNESSETH:

WHEREAS, the Metal Lenders and the Customers are parties to a certain Consignment Agreement,
dated as of October 2, 2009, as amended by that certain (i) Amendment No. 1 to Consignment
Agreement, dated as of March 10, 2010, (ii) Omnibus Amendment to Metal Documents, dated as of June
10, 2010, (iii) Amendment No. 3 to Consignment Agreement, dated as of September 30, 2010, (iv)
Amendment No. 4 to Consignment Agreement, dated as of November 10, 2010, (v) Amendment No. 5 to
Consignment Agreement, dated as of March 7, 2011, and (vi) Amendment No. 6 to Consignment
Agreement, dated as of September 13, 2011 (as amended, the “Consignment Agreement”); and

WHEREAS, the parties hereto desire to amend the Consignment Agreement as set forth herein;

NOW, THEREFORE, for value received and for other good and valuable consideration, the receipt
and adequacy of which are hereby acknowledged, the parties hereto hereby agree as follows:

1. Defined Terms. Initially capitalized terms used but not defined in this Amendment
have the meanings given to such terms in the Consignment Agreement.

2. Amendments.

(a) The definition of “Maturity Date” appearing in Section 1 of the Consignment Agreement is
hereby amended and restated in its entirety to read as follows:

“Maturity Date” means September 30, 2013. Any
obligations of the Customers under this Agreement that are not paid
when due on or before the Maturity Date shall remain subject to the
provisions of this Agreement until all Obligations are paid and
performed in full.

(b) Section 2.6 of the Consignment Agreement is hereby amended and restated in its
entirety to read as follows:

Section 2.6 Inability to Determine Fixed Consignment Fee.

In the event, prior to the commencement of any Fixed Rate
Period relating to any Fixed Rate Consignment, the applicable Metal
Lender shall determine in good faith that adequate and reasonable
methods do not exist for ascertaining the Fixed Consignment Fee that
would otherwise determine the Fixed Rate Consignment during any
Fixed Rate Period, the applicable Metal Lender shall forthwith give
notice of such determination (which shall be conclusive and binding
on the Customer) to the Customer. In such event, (a) any request
for a Fixed Rate Consignment shall be automatically withdrawn and
shall be deemed a request for a Floating Rate Consignment; (b) each
Fixed Rate Consignment will automatically on the last day of the
then current Fixed Rate Period thereof, become a Floating Rate
Consignment; and (c) the obligations of the applicable Metal Lender
to make Fixed Rate Consignments shall be suspended until the
circumstances giving rise to such suspension no longer exist,
whereupon the applicable Metal Lender shall so notify the Customers.

(c) Section 9.1(c) of the Consignment Agreement is hereby amended and restated in its
entirety to read as follows:

(c) concurrently with any delivery of financial statements
under Section 9.1(a) or 9.1(b) above, a certificate
of an executive officer of Materion (i) showing the calculations
necessary to determine compliance with this Agreement, and (ii)
certifying as to whether a Default has occurred and, if a Default
has occurred, specifying the details thereof and any action taken or
proposed to be taken with respect thereto;

(d) Section 9.3 of the Consignment Agreement is hereby amended and restated in its entirety to
read as follows:

Section 9.3 Notices.

Each Customer through the Customer Agent, will give prompt notice in
writing to the Metal Lenders of: (a) the occurrence of any Default;
(b) the filing or commencement of any action, suit or proceeding by
or before any arbitrator or governmental authority against or
affecting any Customer that, if adversely determined, could
reasonably be expected to result in a Material Adverse Effect; (c)
any Lien (other than Permitted Metal Liens) attaching or asserted
against any material portion of the Collateral; (d) any loss,
damage, or destruction to the Collateral in the amount of $500,000
or more, whether or not covered by insurance; (e) the occurrence of
any “Default” under the Senior Credit Agreement or any “Event of
Default” under any Permitted Metals Agreement which is subject to
the Metal Intercreditor Agreement; (f) the occurrence of any
“Default” or “Event of Default” under any other Permitted Metal
Agreement not described in the preceding clause (e) which has
resulted in the exercise or commencement of any creditor remedies
thereunder against Metal in the possession, custody or control of
any Customer; (g) any other development that results in, or could
reasonably be expected to result in, a Material Adverse Effect; and
(h) any amendment, supplement or restatement of the Senior Credit
Agreement, together with a copy thereof. Each notice delivered
under this Section 9.3 shall be accompanied by a statement
of an executive officer of BEM setting forth the details of the
event or development requiring such notice and any action taken or
proposed to be taken with respect thereto.

(e) Section 9.21 of the Consignment Agreement is hereby amended by (i) adding (a)
immediately prior to the existing paragraph and (ii) adding the following new clauses:

(b) No Customer shall obtain Metal on a secured basis (whether
styled as a consignment, loan, conditional sale or other secured
financing) from any supplier, lender, consignor or financial
institution other than the Metal Lenders unless (i) no Metal is
outstanding on Consignment to any Customer under Section 2
hereof, or (ii) such other supplier, lender, consignor or financial
institution executes and delivers to the Collateral Agent a
counterpart or joinder to the Metal Intercreditor Agreement in form
and substance acceptable to the Collateral Agent.

(c) For the avoidance of doubt, each Customer shall be entitled to
(i) purchase Metal for cash from any Person, (ii) enter into hedging
transactions with any Person, and (iii) enter into Client-Customer
Arrangements in the ordinary course of such Customer’s business.

3. Representations and Warranties. To induce the Metal Lenders to enter into
this Amendment, each Customer hereby represents and warrants to the Metal Lenders that: (a) such
Customer has full power and authority, and has taken all action necessary, to execute and deliver
this Amendment and to fulfill its obligations hereunder and to consummate the transactions
contemplated hereby; (b) the making and performance by such Customer of this Amendment do not and
will not violate any law or regulation of the jurisdiction of its organization or any other law or
regulation applicable to it; (c) this Amendment has been duly executed and delivered by such
Customer and constitutes the legal, valid and binding obligation of such Customer, enforceable
against it in accordance with its terms, except as enforceability may be limited by bankruptcy,
insolvency or similar laws affecting the enforcement of creditors’ rights generally and except as
the same may be subject to general principles of equity; and (d) on and as of the date hereof,
after giving effect to this Amendment, no Default or Event of Default exists under the Consignment
Agreement.

4. Governing Law. This Amendment shall be governed by and construed in accordance
with the laws of the State of New York applicable to contracts made and performed in such State.

5. Integration of Amendment into Consignment Agreement. The Consignment Agreement, as
amended hereby, together with the other Metal Documents, is intended by the parties as the final,
complete and exclusive statement of the transactions evidenced by the Consignment Agreement. All
prior or contemporaneous promises, agreements and understandings, whether oral or written, are
deemed to be superseded by the Consignment Agreement, as amended hereby, and no party is relying on
any promise, agreement or understanding not set forth in the Consignment Agreement, as amended
hereby. The Consignment Agreement, as amended hereby, may not be amended or modified except by a
written instrument describing such amendment or modification executed by the Customers and the
Metal Lenders. The parties hereto agree that this Amendment shall in no manner affect or impair
the liens and security interests evidenced or granted by the Consignment Agreement or in connection
therewith. Except as amended hereby, the Consignment Agreement shall remain in full force and
effect and is in all respects hereby ratified and affirmed.

6. Expenses. The Customers covenant and agree jointly and severally to pay all
reasonable out-of-pocket expenses, costs and charges incurred by the Metal Lenders (including
reasonable fees and disbursement of counsel) in connection with the review and implementation of
this Amendment.

7. Signatures. This Amendment may be executed by the parties hereto in several
counterparts hereof and by the different parties hereto on separate counterparts hereof, each of
which shall be an original and all of which shall together constitute one and the same agreement.
Delivery of an executed signature page of this Amendment by electronic transmission shall be
effective as an in hand delivery of an original executed counterpart hereof.

IN WITNESS WHEREOF, the undersigned parties have caused this Amendment to be executed by
their duly authorized officers as of the date first written above.

	 	 	 
	CUSTOMERS:	 	 
	MATERION CORPORATION

By:/s/ Michael C. Hasychak

Michael C. Hasychak

Vice President, Treasurer and Secretary

	 	MATERION ADVANCED MATERIALS TECHNOLOGIES

AND SERVICES INC.

By: /s/ Michael C. Hasychak

—

Michael C. Hasychak

Vice President, Treasurer and Secretary
	MATERION TECHNICAL MATERIALS INC.

By:/s/ Michael C. Hasychak

Michael C. Hasychak

Vice President, Treasurer and Secretary

	 	MATERION BRUSH INC.

By:/s/ Michael C. Hasychak

Michael C. Hasychak

Vice President, Treasurer and Secretary
	MATERION TECHNOLOGIES INC.

By: /s/ Michael C. Hasychak

	 	MATERION BREWSTER LLC

By: /s/ Michael C. Hasychak
	 

	 	 
	Michael C. Hasychak

Chief Financial Officer and Secretary

	 	Michael C. Hasychak

Treasurer
	MATERION PRECISION OPTICS AND THIN FILM

COATINGS CORPORATION

By: /s/ Gary W. Schiavoni

Gary W. Schiavoni

Secretary

	 	MATERION LARGE AREA COATINGS LLC

By: /s/ Gary W. Schiavoni

—

Gary W. Schiavoni

Asst. Secretary and Asst. Treasurer

	MATERION ADVANCED MATERIALS TECHNOLOGIES

AND SERVICES CORP.

By: /s/ Richard W. Sager

Richard W. Sager

	 	MATERION ADVANCED MATERIALS TECHNOLOGIES

AND SERVICES LLC

By: /s/ Richard W. Sager
	
 
	 	 
	President

	 	Richard W. Sager

Manager
	METAL LENDERS:

	 	

	CANADIAN IMPERIAL BANK OF COMMERCE

By: /s/ Eoin Roche

Name: Eoin Roche

	 	CIBC WORLD MARKETS INC.

By: /s/ Eoin Roche

Name: Eoin Roche
	 

	 	 
	Title: Executive Director

	 	Title: Executive Director

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