Document:

LEASE  CONTRACT  FOR  BUSINESS  ROOMS               Contract  No.:  69
                                                    Copy  for  Landlord/Tenant

The  lease  parties  are  referred  to  as  Landlord and Tenant even if they are
composed  of several, maybe legal persons. All persons mentioned in the contract
- in case of firms their legal representatives - must sign the Contract in their
own  hands.  Inapplicable  parts  of  the  Lease Contract must be deleted, empty
spaces  must  be filled in or deleted. If necessary, annex additional sheets and
sign  them.

The
RESEARCH  AND  DEVELOPMENT  CENTRE,  FEZ WITTEN GMBH, ALFRED-HERRHAUSEN-STR. 44,
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58455  WITTEN
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(Landlord)
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and

GLUKOMEDITECH  AG  WITTEN,  ALFRED-HERRHAUSEN-STR.  44,  58455  WITTEN
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(Tenant)
--------

conclude  the  following  Lease  Contract:

  1     LEASED  PROPERTY,  PURPOSE  OF  LEASE,  BEGIN  OF  LEASE

     1.     From  01  JANUARY  2000  on,  the  following  rooms  on the property
Alfred-Herrhausen-Str.  44,  58455  Witten  are  let:

     ON  THE  GROUND FLOOR, THE ROOMS NUMBERED E47, E48, E49, E50 AND E70 WITH A
MAIN  FLOOR  SPACE  OF 93.31 SQ.M. AS WELL  AS  A SHARE OF ANCILLARY FLOOR SPACE
AND CIRCULATION AREA  OF  23.33 SQ.M. THAT RESULTS IN  AN  OVERALL  LEASED  AREA
OF  116.64  SQ.M.

The  underlying  leased area comprises the areas enclosed by the enclosing walls
of  the  leased room, minus supports, if any, without deduction of inside walls.
Ancillary  floor  space  and circulation areas are added to the leased area as a
sq.m.  share  of  25  %  of  the leased rooms. The annexed site plan of the main
leased  rooms  is  a  part  of  this  Contract.

A  deviation  of the agreed leased area from the actual conditions in the leased
property  not  exceeding a range of tolerance of 3 % shall not create a right of
Landlord  or  Tenant  to  claim  a  change  of  the  rent.

For  the  operation  of
OFFICE  AND  LABORATORY  AREAS.
-------------------------------

In  addition,  there  are  let:
UNDERGROUND  PARKING  SPACES  NUMBERED  AS  FOLLOWS:  NONE
----------------------------------------------------------

2.     The  Tenant  is  entitled  to co-use the following parts of the building,
installations  and  technical  systems.

LIFT,  ENTRANCE HALL, STAIRCASE AREA AS WELL AS KITCHEN AND TOILET INSTALLATIONS
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ON  THE  RESPECTIVE  FLOOR  AND  IN
-----------------------------------
THE  RESPECTIVE  PART  OF  THE  BUILDING
----------------------------------------

3.     For  the term of lease, the following keys are handed over to the Tenant.
three  key  per  office  room.
     Upon  termination  of  the lease relationship, all keys must be returned to
the  Landlord.

4.     The  Landlord grants the use of the leased property in its condition upon
handing  over.  The  Tenant  releases  the  Landlord from no-fault liability for
initial  material  defects  (  538  of  the  BGB  -  German  Civil  Code)

5.     The  Landlord makes the following furniture and fittings available to the
Tenant:  NONE

6.     The  Landlord  grants  the  use  of  the leased rooms in the condition as
inspected by the Tenant. Unless otherwise provided in the inspection report, the
Tenant  recognizes  the  condition  of  the  leased  rooms  as  in line with the
contract.

7.     Obligations  imposed by competent authorities are to be met by the Tenant
at  its  own  costs;  the  rooms  may  only  be used for the purpose permissible
according  to  the  respective  government  regulations.

8.     This  Lease Contract is concluded under the condition subsequent that the
security  for rent must have been paid before the leased property is handed over
to  the  Tenant.

<PAGE>

  2     UTILISATION  OF  THE  LEASED ROOMS, ENVIRONMENTAL PROTECTION, SUBLETTING

1.     The  Tenant  may  use  the  leased  rooms  only for the business purposes
specified  in   1.  Any  changes  of  the  purpose  of  use  are  subject to the
Landlord's  approval.

2.     If  the Tenant stores on the property or uses within the framework of its
business  activities  any  substances  harmful  to  water,  the  Tenant  must,
irrespectively  of  an  existing  company  liability insurance, effect a special
insurance  with  regard  to  the storage or utilization of substances harmful to
water  and,  upon  request,  submit  it  to  the  Landlord.  The  same  applies
respectively  to  all  other  kinds  of  immission.  Claims for damages for soil
contamination  caused  by  the  Tenant  shall  become  due  as  soon  as  such
contamination  is  detected  by  an examination of the soil. The Tenant shall be
given  the  opportunity  to  attend  the  examination  of  the  soil.

3.     The  Tenant is responsible for insuring the furniture and fittings of the
leased  rooms  and any goods stored in them against fire, water and burglary. If
the  furniture  and  fittings  brought  in  by the Tenant or its stocks of goods
should cause any damage to the leased rooms, the Tenant shall be liable for such
damage.  The  Landlord  shall effect a suitable insurance against risks, such as
fire,  tap water, sewage or improper release of water from the sprinkler system.

4.     With regard to the insurance effected by the Landlord, in particular fire
insurance, the Tenant must not increase the risk or permit such increase of risk
by  a third party without written approval of the Landlord. The higher insurance
premium  costs  in  connection  with  an increase of risk  shall be borne by the
Tenant.

5.     In  addition to that, the Tenant must comply with any obligations imposed
in  connection  with the increase of risk or bear the costs of the fulfilment of
such  obligations

6.     Any  subletting to or other permission of use by a third party is subject
to  the  Landlord's  approval.

7.     In  case  of  an  unauthorized  subletting,  the Landlord can require the
Tenant  to  terminate  the  subletting relationship as soon as possible, but not
later  than  within  one month. If the Tenant fails to comply with that request,
the  Landlord  can  terminate  the  main lease relationship without notice. That
right  can  only  be  asserted  by  the  Landlord within one month after getting
knowledge  of  the  unauthorized  subletting.

8.     The Landlord is entitled to make its approval of a subletting conditional
upon  the  agreement  on  a  subletting  surcharge.

9.     In  case  of a subletting or other permission of use, the Tenant shall be
liable for any acts or omissions of the subtenant or the person permitted to use
the  leased  rooms,  as  if  it  were  its  own  fault.

10.     For  the  case  of  subletting,  the  Tenant  already now assigns to the
Landlord,  for  security  purposes, all claims due from the subtenant, including
any  right  of  lien,  up  to  the  amount  of  the  Landlord's  claims.

  3     MAXIMUM  FLOOR  LOAD

The  Tenant  must  not  exceed the maximum floor load permissible under building
law,  i.e.  500  KG  PER  SQ.M.

  4     ELECTRICITY,  GAS,  WATER

1.     The  existing  electricity,  gas and water networks shall only be used by
the Tenant to such an extent that no overload will occur. An additional need can
be  satisfied  by  the  Tenant by extending the supply lines at its own expense,
subject  to  the  prior  consent  of  the  Landlord.

2.     Water  shall  only  be  drawn  from the water line for the usual purposes
(drinking  water,  sanitary purposes). In case of water consumption for business
purposes,  the  Tenant  must  install, at its own expense, an intermediate water
meter  and  bear the water supply and sewage costs as indicated by the Landlord,
unless  the  Tenant  purchases  water  directly  from  the  waterworks.

3.     In  case  of  any failure or defects in the supply lines, the Tenant must
ensure  their immediate disconnection and shall be obliged to immediately inform
the  Landlord  or  its  agent.

4.     Any  changes in the energy supply, in particular a change of the voltage,
does  not  entitle  the Tenant to assert any claims for compensation against the
Landlord.

5.     If  the  electricity, gas or water supply or the sewerage are interrupted
by  a  condition that the Tenant is not responsible for or in case of inundation
or  other  disasters, the Tenant shall have no right to claim rent reduction and
compensation  against  the  Landlord.

<PAGE>

  5     REPAIR  WORK  AND  STRUCTURAL  ALTERATIONS  BY  THE  LANDLORD

1.     The  Landlord  is entitled, even without the Tenant's consent, to perform
repair work and structural alterations that become necessary for the maintenance
of the building or of the leased rooms, for averting imminent dangers or for the
repair  of  damage.  The same shall apply to any work that is not necessary, but
appropriate,  such  as  a modernization of building and leased rooms. The Tenant
shall  keep the affected rooms accessible and must not hinder or delay the work.

2.     The Landlord can convert the central heating or hot water supply to other
fuel types or have them connected to the distant heating system and install heat
counters,  heating  cost  distributors,  hot  water  meters,  hot  water  cost
distributors  and  thermostats.

  6     STRUCTURAL  ALTERATIONS  BY  THE  TENANT

1.     Any  structural  alterations by the Tenant, in particular conversions and
installations,  including  the  grating  of  windows  and  the  installation  or
modification  of  fireplaces,  may  only  be  performed  with the consent of the
Landlord.  If  the  Landlord gives such consent, the Tenant shall be responsible
for  obtaining  the  required  building  permit  and  bear  all  costs  of  such
alteration.

2.     Upon  termination of the lease relationship, the Landlord shall take over
all  structural  changes  made  by  the  Tenant without any compensation for the
Tenant.

  7     UTILIZATION  OF  THE  LIFTS

To the extent as the Tenant is entitled to use or co-use lift systems, it has no
right  to  uninterrupted  operation in case of failure of the system. The Tenant
undertakes  to  observe  all items of the lift regulations. There is no operator
provided for the lifts. Any failure must be immediately reported to the Landlord
or  its agent. Any damage caused by the use of the lifts shall only be made good
by the Tenant if it has caused such damage intentionally or by gross negligence.

  8     CHANGE  OF  THE  LEGAL  FORM,  SALE  OF  THE  BUSINESS

1.     In  case  of  a change of the legal form of the Tenant's business, of any
changes  in  the Commercial Register, in the registration of the trade or in any
other conditions relevant to the lease relationship, the Tenant must immediately
inform  the  Landlord  of  such  changes.

2.     In case of a sale of the Tenant's business in part or as a whole, a prior
agreement  with  the Landlord shall be required with regard to the assignment of
this Contract to the legal successor. There is no right to an assignment of this
Contract.

  9     LANDLORD'S  ACCESS  TO  THE  LEASED  ROOMS

1.     The  Landlord  and/or  its  agent  can  enter the leased rooms during the
business hours for an inspection of their state or for other good cause. In case
of  danger,  access  is  permitted  at  any  time,  day  or  night.

2.     If  the  Landlord  intents  to sell the property, the Landlord and/or its
agent  can  enter  the leased rooms together with the potential buyer during the
office  hours.  If the lease relationship is terminated, the Landlord and/or its
agent  can  enter the leased rooms together with the potential tenant during the
office  hours.

3.     The  Tenant  must  see  to  it  that  the rooms can be entered during its
absence.  During a prolonged absence (e.g. company holiday), it must deposit the
keys  at  an  easily  accessible  place  and  inform  the Landlord respectively.

<PAGE>
  10     RENT  AND  ANCILLARY  COSTS

1.     The BASIC NET RENT for the leased rooms according to   1 No. 1, exclusive
of  ancillary  costs (operating  and  heating  costs)  is

          DM  17.25  x  116.64  sq.m.     presently  per month      DM  2,012.00

1.1     In addition to the rent, there shall be paid an advance on operating and
heating  costs according to 13, determined on the basis of the Landlords last
accounting DM  5.50  x  116.64  sq.m.     presently per month      DM     641.51
1.3     Rent  for underground parking spaces     DM 50.00 x 0 pcs.
                                          presently per  month     DM       0.00
                                                                 ---------------
1.4     TOTAL  AMOUNT                     PRESENTLY  PER  MONTH    DM   2,653.50

1.5     plus  VAT  16  %                  presently  per  month    DM     424.56
---                                                                -------------

1.6     TOTAL  AMOUNT                     PRESENTLY  PER  MONTH    DM   3,078.05
                                                                    ------------

2.     The  operating  costs are the costs set out in   13 of this Contract. The
Tenant  shall bear the operating costs according to   13 on a pro-rata basis for
the overall space let to the Tenant (cf.   1 No. 1) in proportion to the overall
lettable  area  of  the  FEZ  (5,587.35  sq.m.).  The  ancillary costs for waste
disposal,  WC  cleaning  and  hygiene expenses shall be borne by the Tenant on a
pro-rata  basis  for  the  overall  space let to the Tenant in proportion to the
actually  let  area of the FEZ. For further details on operating costs, see   13
below.

3.     As far as operating costs increase, decrease, are newly incurred or cease
to  be incurred, this shall be taken into account in the pro-rata calculation of
the  cost  allocation. Accordingly, the Landlord shall be entitled to revise the
advance  on  operating costs when the advance does not cover the operating costs
incurred anymore. The Tenant, on its part, can demand a reduction of the advance
when  it  turns  out  to  bee  too  high.

4.     Upon  request  of the Landlord, the Tenant of the rooms used for business
or  independent  freelance  purposes  shall  pay, in addition to the rent, value
added  tax at the respectively applicable rate if the Landlord has opted for the
duty  to  pay  VAT  according to   9 of the USTG (turnover tax law). The parties
know  the  regulations  of  the  turnover tax law. In such case, the Landlord is
obliged  to  issue  the  required  input  tax  receipts  to  the  Tenant.

5.     The  interior  decorative  repairs  shall  be  paid  by  THE  TENANT.
     The  party obliged must have the interior decorative repairs performed in a
regular  and  professional  manner.

6.     Minor  maintenance  and  repair  of  all  of the installations inside its
leased  rooms  up  to a value of DM 300.00 plus VAT per individual case shall be
paid  by  THE  TENANT,  however  only  up  to  the  amount  of one monthly rent.
     The  party  obliged  must have the work performed in a professional manner.
(see  also   14  Subsec.  6).

  11     TERM  OF  LEASE,  OPTION,  TERMINATION

     The  lease  relationship  starts  on                01  JANUARY  2000
     It  is  for  a  DEFINITE  PERIOD  and  ends  on     31  MARCH  2003
     The  Tenant  has  a  non-recurring  option  right  to  continue  the  lease
relationship  for  another  term  of  5  years.
     That  right  must be asserted not later than 6 months before the expiration
of  the  Contract.

2.     A termination, objection as well the exercise of the option right must be
made  in  WRITING  and  must be received by the respective other party not later
than  on  the  last  working  day  before  the  begin  of  the  notice  period.

3.     During  the  termination  period,  the  Tenant  must permit the fixing of
"rooms  to  let"  posters  on  the  windows  and  other  suitable  places.

4.     The  Landlord  can  terminate  the  Lease  Contract  for  good cause with
immediate  effect  without  observing  a  notice  period  if the Tenant fails to
perform  its  contractual  obligations  (e.g. payment in arrears of at least two
monthly  rents,  substantial arrears of operating costs and/or heating costs and
substantial  nuisance to the Landlord and other tenants despite written warning,
utilization  in  breach  of the contract, unauthorized letting to a third party,
etc.)

5.     In  case  of  a  termination  by  the Landlord without observing a notice
period, the Tenant shall be liable for any losses of rent, ancillary charges and
other  services.

6.     The  Contract  shall  not  be  annulled  by the death of the Tenant. Both
parties  waive  the  right  of  early  termination  under   569  of  the  BGB.

7.     Upon  expiration  of  the  term  of  lease,   568 of the BGB shall not be
applicable  to  the  parties.

<PAGE>

  12     CENTRAL  HEATING  AND  HOT  WATER  SUPPLY

1.     The Landlord is obliged to operate the central heating as far as required
by  the  outside temperatures, however at least during the period from 1 October
to  30 April. On Saturdays, Sundays and public holidays the Tenant does not have
a  right  to  a  provision  of  central  heating.

2.     The  Tenant is obliged to pay pro-rata operating and maintenance costs. A
partial  or  complete  discontinuation  of  the  heating  caused by a local fuel
shortage does not entitle the Tenant to claim any reduction or damages. The same
shall  apply  to  any  kind  of  necessary  interruptions  of  the  supply.

3.     The  costs  of  the  central  heating  shall be allocated by the Landlord
within  the  bounds  of  the  legal  regulations as to accounting criteria, e.g.
according  to usable floor space or enclosed space. If there exist heat counters
or  heating cost distributors, a part of the costs of not less than 50 % and not
more  than 70 % shall be allocated on the basis of the consumption (according to
the  Regulation on Heating Cost Accounting of 23 February 1981, BGBl. I p. 261).
Monthly advance shall be paid on the allocated amount for the heating costs, the
amount of such advance being adequately determined by the Landlord and accounted
for  after  the  end  of  the  heating period. Upon the existence of appropriate
reasons,  the  Landlord  shall be entitled to change the allocation criteria for
future  accounting  periods.

4.     If  instantaneous  water  heaters  or  boilers for the preparation of hot
water  are  installed  in the leased rooms, the Tenant shall bear all operating,
maintenance  and  cleaning  costs,  in accordance with Appendix 3 of   27 of the
Second  Calculation Regulation. Maintenance and cleaning shall be done annually.

  13     ACCOUNTING  OF  OPERATING  AND  ANCILLARY  COSTS

1.     Operating  costs comprise the following costs for which a monthly advance
shall  be  paid:

The current public charges, in particular all property charges, such as property
tax,  street  cleaning
Refuse  collection
Costs  of  central  heating  and  its  maintenance
Electricity  supply  and  maintenance  of  the  electric  systems
Sewerage, including the costs of the operation and maintenance of drainage pumps
Monitoring,  operation  and  maintenance  of  the  lift  systems
House  cleaning  and  vermin  control,  general  house  cleaning
Intruder  alarm  system  and  its  maintenance
Hygiene  costs  (WC,  materials,  disposal  and  ventilation)
Gardening  as  well  as  maintenance of the outside installations, including the
replacement  of  plants  and  trees
Lighting  costs
Chimney  cleaning
Costs  of  water supply, in particular costs of water consumption, basic charges
and  the  meter  rent,  current  costs  of the use of intermediate meters (incl.
gauging  fees),  costs  of  operation  and maintenance of the house water supply
system.
Building,  property  and  liability  insurance
Caretaker  and  house  inspection
Building  and  glass  cleaning
Winter  service
Guarding  of  the  building
Maintenance  of  doors  and  windows
Fire  protection  and  maintenance,  inc.  fire  extinguishers

Further operating and maintenance costs of all above and non mentioned technical
installations  of  the  building,  in particular parking installations, entrance
doors,  barrier  systems,  ventilation  and  air-conditioning systems, emergency
power  units and illumination, bell and intercom systems, smoke control systems,
sprinkler  systems, fire alarm systems as well as any other security systems and
hot-water  supply  systems.

2.     The  advance  on  operating  and  ancillary  expenses (see   10) shall be
accounted  for  annually.  The Tenant is entitled to inspect the books within an
appropriate period after the receipt of the account.  - In case of a move of the
Tenant  during the accounting period, the allocation shall be made upon the next
regular  accounting for the remaining time of lease compared with the accounting
period.

  14     MAINTENANCE  OF  THE  ROOMS

1.     Any  damage  on  or  inside  the building and in the leased rooms must be
immediately  reported  to  the Landlord or its agent. The Tenant shall be liable
for  further  damage  caused  by  delayed  notification.

2.     The  Tenant  shall  be  liable  to  the Landlord for any damage caused by
culpable  failure  to  exercise  the  proper  care  incumbent  on the Tenant, in
particular  if  supply  and sewerage lines, toilets, heating installations, etc.
are  improperly  treated,  the  rooms are not sufficiently ventilated, heated or
protected  against  frost. Line clogging up to the main pipe shall be removed by
the  Tenant  at  its  expense  in  any  case.

<PAGE>

3.     In  the  same  manner, the Tenant shall be liable for any damage culpably
caused by its members, employees, subtenants, visitors, suppliers and craftsmen.

4.     Any damaged panes of glass and mirrors shall be replaced by the Tenant at
its  expense  in  any  case.  The Landlord assigns claims against culpable third
parties,  if any, to the Tenant. The Landlord shall not be obliged, but entitled
to insure all panes of glass and mirrors. The costs of such insurance, including
subsequent  insurance,  shall  be  borne  by  the  Tenant.

5.     Any  germination  of the leased property must be removed by the Tenant at
its  expense.  The  same  applies  to  any  free  spaces  leased  or  used.

6.     Minor maintenance/repairs shall be carried out by the party obliged (  10
Subsec.  8)  at  its  expense,  unless the damage was caused by the respectively
other  party.  Minor  maintenance/repairs  include the repair of minor damage as
well  as  the maintenance of lines and installations for water, electricity, gas
and  heating, of sanitary facilities, locks of windows, doors, shutters, blinds,
awnings  and  similar  installations.

7.     The  Tenant  must immediately fix any damage that its is responsible for.
If  the  Tenant  fails to comply with that obligation even within an appropriate
period  after receiving a respective notice, the Landlord can have the necessary
work  performed  at  the Tenant's expense. In case of imminent danger or unknown
whereabouts  of  the Tenant, a written notice and the granting of a period shall
not  be  required.

8.     The  tenant expressly indemnifies the Landlord against any liability with
regard  to  the leased property, unless such liability is culpably caused by the
Landlord.

  15     END  OF  THE  TERM  OF  LEASE

At  the  end of the term of lease, the Tenant must hand the leased rooms over to
the Landlord in a completely cleared, clean and freshly renovated condition. The
walls  shall  be  painted  uniformly  in  the  colour  type  Taiga 18. All keys,
including  any  additionally purchased keys, must be handed over to the Landlord
without  claim  for  compensation.  Otherwise, the Landlord shall be entitled to
have  the  leased  rooms opened, cleaned and painted and have new locks and keys
made  at  the  Tenant's  expense.

  16     OTHER  STIPULATIONS

1.     Landlord  and/or  Tenant  shall be jointly and severally liable as far as
they  are  formed by several persons. A notice of the Landlord shall be regarded
as  effective  when  it  is  given  to  one  of  the  Tenants.

2.     Should  any  provision  of  this Contract be or become legally invalid in
part or as a whole, this shall not affect the validity of the remaining parts of
the  contract. The contracting parties undertake to newly agree upon any invalid
provisions  in  a  legally  perfect  form  upon  the request of the other party.

3.     Any alterations of or additions to this Contract must be made in writing.

4.     The  place  of  performance  and  of  jurisdiction  is  Witten.

  17     PAYMENT  OF  RENT  AND  ANCILLARY  COSTS

Rent and ancillary costs shall be paid monthly in advance, not later than by the
3rd  working  day of the respective month, free of charge, to the Landlord or to
the  person  or  body  authorized  by  the  Landlord  to  receive  it.

     RENT  AND  ANCILLARY  COSTS  SHALL  BE  PAID  INTO  THE  ACCOUNT  NO. 49163
     AT  STADTSPARKASSE  WITTEN  (BANK  CODE  NO.  452  500  35)

The  timeliness  of the payment does not depend on the date of transmission, but
on  the  date  of  receipt  of  the  money.

In  case of late payment, the Landlord shall be entitled to charge dunning costs
to  an  amount  of  DM  50.00  per  dunning  notice, notwithstanding any default
interest.

<PAGE>
  18     LANDLORD'S  LIEN  -  PROVISION  OF  SECURITY

1.     The  Tenant declares that the items brought in upon moving into the rooms
are  its  free  property  and  that  they  are  not  seized  or  pledged,

     with  the  exception  of  the  following  items:    NONE

2.     The  Tenant  is  obliged  to  immediately  inform  the  Landlord about an
attachment  of  items  brought  in,  indicating  the  bailiff  and the attaching
creditor.

3.     Provision  of  security

     The  Tenant  HAS  ALREADY provided the Landlord with the a security for the
performance  of  its  obligations
     and/or for the payment of claims for damages to the amount of 2 monthly net
rent  payments

4.     From  the  date  of  receipt  of  the security on, the Landlord shall pay
interest  on  it at the usual rate for saving deposits with three months' period
of  notice.  -  The  interest shall increase the security. The security shall be
paid  before the leased rooms are handed over. - The security can be replaced by
a  bank  guarantee  at  any  time.

5.     The  guarantee,  together  with  the  interest, shall be paid back to the
Tenant  upon  termination of the lease relationship, provided it is certain that
there  are  no  claims  against  the  Tenant.

6.     The  rent  shall  remain  unchanged  until  31  March  2003.

  19     ADVERTISING  MEASURES  /  OUTDOOR  ADVERTISING

     The Tenant is entitled to fix advertising signs to the following areas:  as
agreed

     In  case  there exist or are installed collective sign carriers, the Tenant
shall  be  obliged  to use such systems and assume     pro-rata costs. (see also
the  House  Rules).

  20     PROTECTION  AGAINST  COMPETITION

     PROTECTION  OF  THE  TENANT  AGAINST  COMPETITION  IS  EXCLUDED.

  21     FURTHER  PROVISIONS

1.     In  performing  its  business  activities,  the  Tenant  must observe all
applicable  regulations  with  regard  to  environmental  protection.

2.     The  agreements  included in this Lease Contract, in particular the House
Rules,  are  essential  parts  of  this  Contract.

3.     Every  Tenant  is  jointly and severally liable for all obligations under
this  Lease  Contract.

Witten,  13  April  2000                         Witten,  06  June  2000

/signature/                                      /signature/
RESEARCH  AND  DEVELOPMENT  CENTRE
FEZ  WITTEN  GMBH                                SANGUIBIOTECH  AG
 (Landlord)                                     (Tenant)

                    I HEREBY CERTIFY THAT THIS IS A TRUE AND
                      COMPLETE TRANSLATION OF THE PRESENTED
                        GERMAN DOCUMENT. THIS TRANSLATION
                    COMPRISES 1 PAGES (including this page).

                              Berlin, 28 July 2000

                                  Jochen Wendt
         Graduate Interpreter/Translator for German, English, Portuguese
        Generally Sworn Interpreter for the Courts and Notaries of BerlinLEASE  CONTRACT  FOR  BUSINESS  ROOMS               Contract  No.:  68
                                                    Copy  for  Landlord/Tenant

The  lease  parties  are  referred  to  as  Landlord and Tenant even if they are
composed  of several, maybe legal persons. All persons mentioned in the contract
- in case of firms their legal representatives - must sign the Contract in their
own  hands.  Inapplicable  parts  of  the  Lease Contract must be deleted, empty
spaces  must  be filled in or deleted. If necessary, annex additional sheets and
sign  them.

The
RESEARCH  AND  DEVELOPMENT  CENTRE,  FEZ WITTEN GMBH, ALFRED-HERRHAUSEN-STR. 44,
--------------------------------------------------------------------------------
58455  WITTEN
-------------
(Landlord)
----------

and

SANGUIBIOTECH  AG  WITTEN,  ALFRED-HERRHAUSEN-STR.  44,  58455  WITTEN
----------------------------------------------------------------------
(Tenant)
--------

conclude  the  following  Lease  Contract:

  1     LEASED  PROPERTY,  PURPOSE  OF  LEASE,  BEGIN  OF  LEASE

     1.     From  01  JANUARY  2000  on,  the  following  rooms  on the property
Alfred-Herrhausen-Str.  44,  58455  Witten  are  let:

     ON  THE  GROUND  FLOOR, THE ROOMS NUMBERED E51, E52, E54 TO E66 WITH A MAIN
FLOOR  SPACE  OF  287.63  SQ.M.  AS
     WELL  AS  A  SHARE  OF  ANCILLARY FLOOR SPACE AND CIRCULATION AREA OF 71.91
SQ.M.  THAT  RESULTS  IN  AN  OVERALL  LEASED
     AREA  OF  359.54  SQ.M.

The  underlying  leased area comprises the areas enclosed by the enclosing walls
of  the  leased room, minus supports, if any, without deduction of inside walls.
Ancillary  floor  space  and circulation areas are added to the leased area as a
sq.m.  share  of  25  %  of  the leased rooms. The annexed site plan of the main
leased  rooms  is  a  part  of  this  Contract.

A  deviation  of the agreed leased area from the actual conditions in the leased
property  not  exceeding a range of tolerance of 3 % shall not create a right of
Landlord  or  Tenant  to  claim  a  change  of  the  rent.

For  the  operation  of
OFFICE  AND  LABORATORY  AREAS.
-------------------------------

In  addition,  there  are  let:
UNDERGROUND  PARKING  SPACES  NUMBERED  AS  FOLLOWS:  NONE
----------------------------------------------------------

2.     The  Tenant  is  entitled  to co-use the following parts of the building,
installations  and  technical  systems.

LIFT,  ENTRANCE HALL, STAIRCASE AREA AS WELL AS KITCHEN AND TOILET INSTALLATIONS
--------------------------------------------------------------------------------
ON  THE  RESPECTIVE  FLOOR  AND  IN  THE  RESPECTIVE  PART  OF  THE  BUILDING
-----------------------------------------------------------------------------

3.     For  the term of lease, the following keys are handed over to the Tenant.
three  key  per  office  room.
     Upon  termination  of  the lease relationship, all keys must be returned to
the  Landlord.

4.     The  Landlord grants the use of the leased property in its condition upon
handing  over.  The  Tenant  releases  the  Landlord from no-fault liability for
initial  material  defects  (  538  of  the  BGB  -  German  Civil  Code)

5.     The  Landlord makes the following furniture and fittings available to the
Tenant:  NONE

6.     The  Landlord  grants  the  use  of  the leased rooms in the condition as
inspected by the Tenant. Unless otherwise provided in the inspection report, the
Tenant  recognizes  the  condition  of  the  leased  rooms  as  in line with the
contract.

7.     Obligations  imposed by competent authorities are to be met by the Tenant
at  its  own  costs;  the  rooms  may  only  be used for the purpose permissible
according  to  the  respective  government  regulations.

8.     This  Lease Contract is concluded under the condition subsequent that the
security  for rent must have been paid before the leased property is handed over
to  the  Tenant.

<PAGE>

  2     UTILISATION  OF  THE  LEASED ROOMS, ENVIRONMENTAL PROTECTION, SUBLETTING

1.     The  Tenant  may  use  the  leased  rooms  only for the business purposes
specified  in   1.  Any  changes  of  the  purpose  of  use  are  subject to the
Landlord's  approval.

2.     If  the Tenant stores on the property or uses within the framework of its
business  activities  any  substances  harmful  to  water,  the  Tenant  must,
irrespectively  of  an  existing  company  liability insurance, effect a special
insurance  with  regard  to  the storage or utilization of substances harmful to
water  and,  upon  request,  submit  it  to  the  Landlord.  The  same  applies
respectively  to  all  other  kinds  of  immission.  Claims for damages for soil
contamination  caused  by  the  Tenant  shall  become  due  as  soon  as  such
contamination  is  detected  by  an examination of the soil. The Tenant shall be
given  the  opportunity  to  attend  the  examination  of  the  soil.

3.     The  Tenant is responsible for insuring the furniture and fittings of the
leased  rooms  and any goods stored in them against fire, water and burglary. If
the  furniture  and  fittings  brought  in  by the Tenant or its stocks of goods
should cause any damage to the leased rooms, the Tenant shall be liable for such
damage.  The  Landlord  shall effect a suitable insurance against risks, such as
fire,  tap water, sewage or improper release of water from the sprinkler system.

4.     With regard to the insurance effected by the Landlord, in particular fire
insurance, the Tenant must not increase the risk or permit such increase of risk
by  a third party without written approval of the Landlord. The higher insurance
premium  costs  in  connection  with  an increase of risk  shall be borne by the
Tenant.

5.     In  addition to that, the Tenant must comply with any obligations imposed
in  connection  with the increase of risk or bear the costs of the fulfilment of
such  obligations

6.     Any  subletting to or other permission of use by a third party is subject
to  the  Landlord's  approval.

7.     In  case  of  an  unauthorized  subletting,  the Landlord can require the
Tenant  to  terminate  the  subletting relationship as soon as possible, but not
later  than  within  one month. If the Tenant fails to comply with that request,
the  Landlord  can  terminate  the  main lease relationship without notice. That
right  can  only  be  asserted  by  the  Landlord within one month after getting
knowledge  of  the  unauthorized  subletting.

8.     The Landlord is entitled to make its approval of a subletting conditional
upon  the  agreement  on  a  subletting  surcharge.

9.     In  case  of a subletting or other permission of use, the Tenant shall be
liable for any acts or omissions of the subtenant or the person permitted to use
the  leased  rooms,  as  if  it  were  its  own  fault.

10.     For  the  case  of  subletting,  the  Tenant  already now assigns to the
Landlord,  for  security  purposes, all claims due from the subtenant, including
any  right  of  lien,  up  to  the  amount  of  the  Landlord's  claims.

  3     MAXIMUM  FLOOR  LOAD

The  Tenant  must  not  exceed the maximum floor load permissible under building
law,  i.e.  500  KG  PER  SQ.M.

  4     ELECTRICITY,  GAS,  WATER

1.     The  existing  electricity,  gas and water networks shall only be used by
the Tenant to such an extent that no overload will occur. An additional need can
be  satisfied  by  the  Tenant by extending the supply lines at its own expense,
subject  to  the  prior  consent  of  the  Landlord.

2.     Water  shall  only  be  drawn  from the water line for the usual purposes
(drinking  water,  sanitary purposes). In case of water consumption for business
purposes,  the  Tenant  must  install, at its own expense, an intermediate water
meter  and  bear the water supply and sewage costs as indicated by the Landlord,
unless  the  Tenant  purchases  water  directly  from  the  waterworks.

3.     In  case  of  any failure or defects in the supply lines, the Tenant must
ensure  their immediate disconnection and shall be obliged to immediately inform
the  Landlord  or  its  agent.

4.     Any  changes in the energy supply, in particular a change of the voltage,
does  not  entitle  the Tenant to assert any claims for compensation against the
Landlord.

5.     If  the  electricity, gas or water supply or the sewerage are interrupted
by  a  condition that the Tenant is not responsible for or in case of inundation
or  other  disasters, the Tenant shall have no right to claim rent reduction and
compensation  against  the  Landlord.

<PAGE>

  5     REPAIR  WORK  AND  STRUCTURAL  ALTERATIONS  BY  THE  LANDLORD

1.     The  Landlord  is entitled, even without the Tenant's consent, to perform
repair work and structural alterations that become necessary for the maintenance
of the building or of the leased rooms, for averting imminent dangers or for the
repair  of  damage.  The same shall apply to any work that is not necessary, but
appropriate,  such  as  a modernization of building and leased rooms. The Tenant
shall  keep the affected rooms accessible and must not hinder or delay the work.

2.     The Landlord can convert the central heating or hot water supply to other
fuel types or have them connected to the distant heating system and install heat
counters,  heating  cost  distributors,  hot  water  meters,  hot  water  cost
distributors  and  thermostats.

  6     STRUCTURAL  ALTERATIONS  BY  THE  TENANT

1.     Any  structural  alterations by the Tenant, in particular conversions and
installations,  including  the  grating  of  windows  and  the  installation  or
modification  of  fireplaces,  may  only  be  performed  with the consent of the
Landlord.  If  the  Landlord gives such consent, the Tenant shall be responsible
for  obtaining  the  required  building  permit  and  bear  all  costs  of  such
alteration.

2.     Upon  termination of the lease relationship, the Landlord shall take over
all  structural  changes  made  by  the  Tenant without any compensation for the
Tenant.

  7     UTILIZATION  OF  THE  LIFTS

To the extent as the Tenant is entitled to use or co-use lift systems, it has no
right  to  uninterrupted  operation in case of failure of the system. The Tenant
undertakes  to  observe  all items of the lift regulations. There is no operator
provided for the lifts. Any failure must be immediately reported to the Landlord
or  its agent. Any damage caused by the use of the lifts shall only be made good
by the Tenant if it has caused such damage intentionally or by gross negligence.

  8     CHANGE  OF  THE  LEGAL  FORM,  SALE  OF  THE  BUSINESS

1.     In  case  of  a change of the legal form of the Tenant's business, of any
changes  in  the Commercial Register, in the registration of the trade or in any
other conditions relevant to the lease relationship, the Tenant must immediately
inform  the  Landlord  of  such  changes.

2.     In case of a sale of the Tenant's business in part or as a whole, a prior
agreement  with  the Landlord shall be required with regard to the assignment of
this Contract to the legal successor. There is no right to an assignment of this
Contract.

  9     LANDLORD'S  ACCESS  TO  THE  LEASED  ROOMS

1.     The  Landlord  and/or  its  agent  can  enter the leased rooms during the
business hours for an inspection of their state or for other good cause. In case
of  danger,  access  is  permitted  at  any  time,  day  or  night.

2.     If  the  Landlord  intents  to sell the property, the Landlord and/or its
agent  can  enter  the leased rooms together with the potential buyer during the
office  hours.  If the lease relationship is terminated, the Landlord and/or its
agent  can  enter the leased rooms together with the potential tenant during the
office  hours.

3.     The  Tenant  must  see  to  it  that  the rooms can be entered during its
absence.  During a prolonged absence (e.g. company holiday), it must deposit the
keys  at  an  easily  accessible  place  and  inform  the Landlord respectively.

<PAGE>
  10     RENT  AND  ANCILLARY  COSTS

1.     The BASIC NET RENT for the leased rooms according to   1 No. 1, exclusive
--
of  ancillary  costs
     (operating  and  heating  costs)  is

          DM  17.25  x  359.54  sq.m.     presently  per month      DM  6,202.02

1.1     In addition to the rent, there shall be paid an advance on operating and
heating  costs
     according to   13, determined on the basis of the Landlords last accounting
          DM  5.50  x  359.54  sq.m.     presently  per month       DM  1,977.46
1.3     Rent  for underground parking spaces     DM 50.00 x 0 pcs.
                                         presently per  month       DM      0.00
                                                                 ---------------
1.4     TOTAL  AMOUNT                    PRESENTLY  PER  MONTH      DM  8,179.48

1.5     plus  VAT  16  %                 presently  per  month      DM  1,308.72
---                                                                 ------------

1.6     TOTAL  AMOUNT                    PRESENTLY  PER  MONTH      DM  9.488.19
                                                                    ------------

2.     The  operating  costs are the costs set out in   13 of this Contract. The
Tenant  shall bear the operating costs according to   13 on a pro-rata basis for
the overall space let to the Tenant (cf.   1 No. 1) in proportion to the overall
lettable  area  of  the  FEZ  (5,587.35  sq.m.).  The  ancillary costs for waste
disposal,  WC  cleaning  and  hygiene expenses shall be borne by the Tenant on a
pro-rata  basis  for  the  overall  space let to the Tenant in proportion to the
actually  let  area of the FEZ. For further details on operating costs, see   13
below.

3.     As far as operating costs increase, decrease, are newly incurred or cease
to  be incurred, this shall be taken into account in the pro-rata calculation of
the  cost  allocation. Accordingly, the Landlord shall be entitled to revise the
advance  on  operating costs when the advance does not cover the operating costs
incurred anymore. The Tenant, on its part, can demand a reduction of the advance
when  it  turns  out  to  bee  too  high.

4.     Upon  request  of the Landlord, the Tenant of the rooms used for business
or  independent  freelance  purposes  shall  pay, in addition to the rent, value
added  tax at the respectively applicable rate if the Landlord has opted for the
duty  to  pay  VAT  according to   9 of the USTG (turnover tax law). The parties
know  the  regulations  of  the  turnover tax law. In such case, the Landlord is
obliged  to  issue  the  required  input  tax  receipts  to  the  Tenant.

5.     The  interior  decorative  repairs  shall  be  paid  by  THE  TENANT.
     The  party obliged must have the interior decorative repairs performed in a
regular  and  professional  manner.

6.     Minor  maintenance  and  repair  of  all  of the installations inside its
leased  rooms  up  to a value of DM 300.00 plus VAT per individual case shall be
paid  by  THE  TENANT,  however  only  up  to  the  amount  of one monthly rent.
     The  party  obliged  must have the work performed in a professional manner.
(see  also   14  Subsec.  6).

  11     TERM  OF  LEASE,  OPTION,  TERMINATION

     The  lease  relationship  starts  on                01  JANUARY  2000
     It  is  for  a  DEFINITE  PERIOD  and  ends  on     31  MARCH  2003
     The  Tenant  has  a  NON-RECURRING  OPTION  RIGHT  to  continue  the  lease
relationship  for  another  term  of  5  years.
     That  right  must be asserted not later than 6 months before the expiration
of  the  Contract.

2.     A termination, objection as well the exercise of the option right must be
made  in  WRITING  and  must be received by the respective other party not later
than  on  the  last  working  day  before  the  begin  of  the  notice  period.

3.     During  the  termination  period,  the  Tenant  must permit the fixing of
"rooms  to  let"  posters  on  the  windows  and  other  suitable  places.

4.     The  Landlord  can  terminate  the  Lease  Contract  for  good cause with
immediate  effect  without  observing  a  notice  period  if the Tenant fails to
perform  its  contractual  obligations  (e.g. payment in arrears of at least two
monthly  rents,  substantial arrears of operating costs and/or heating costs and
substantial  nuisance to the Landlord and other tenants despite written warning,
utilization  in  breach  of the contract, unauthorized letting to a third party,
etc.)

5.     In  case  of  a  termination  by  the Landlord without observing a notice
period, the Tenant shall be liable for any losses of rent, ancillary charges and
other  services.

6.     The  Contract  shall  not  be  annulled  by the death of the Tenant. Both
parties  waive  the  right  of  early  termination  under   569  of  the  BGB.

7.     Upon  expiration  of  the  term  of  lease,   568 of the BGB shall not be
applicable  to  the  parties.

<PAGE>

  12     CENTRAL  HEATING  AND  HOT  WATER  SUPPLY

1.     The Landlord is obliged to operate the central heating as far as required
by  the  outside temperatures, however at least during the period from 1 October
to  30 April. On Saturdays, Sundays and public holidays the Tenant does not have
a  right  to  a  provision  of  central  heating.

2.     The  Tenant is obliged to pay pro-rata operating and maintenance costs. A
partial  or  complete  discontinuation  of  the  heating  caused by a local fuel
shortage does not entitle the Tenant to claim any reduction or damages. The same
shall  apply  to  any  kind  of  necessary  interruptions  of  the  supply.

3.     The  costs  of  the  central  heating  shall be allocated by the Landlord
within  the  bounds  of  the  legal  regulations as to accounting criteria, e.g.
according  to usable floor space or enclosed space. If there exist heat counters
or  heating cost distributors, a part of the costs of not less than 50 % and not
more  than 70 % shall be allocated on the basis of the consumption (according to
the  Regulation on Heating Cost Accounting of 23 February 1981, BGBl. I p. 261).
Monthly advance shall be paid on the allocated amount for the heating costs, the
amount of such advance being adequately determined by the Landlord and accounted
for  after  the  end  of  the  heating period. Upon the existence of appropriate
reasons,  the  Landlord  shall be entitled to change the allocation criteria for
future  accounting  periods.

4.     If  instantaneous  water  heaters  or  boilers for the preparation of hot
water  are  installed  in the leased rooms, the Tenant shall bear all operating,
maintenance  and  cleaning  costs,  in accordance with Appendix 3 of   27 of the
Second  Calculation Regulation. Maintenance and cleaning shall be done annually.

  13     ACCOUNTING  OF  OPERATING  AND  ANCILLARY  COSTS

1.     Operating  costs comprise the following costs for which a monthly advance
shall  be  paid:

The current public charges, in particular all property charges, such as property
tax,  street  cleaning
Refuse  collection
Costs  of  central  heating  and  its  maintenance
Electricity  supply  and  maintenance  of  the  electric  systems
Sewerage, including the costs of the operation and maintenance of drainage pumps
Monitoring,  operation  and  maintenance  of  the  lift  systems
House  cleaning  and  vermin  control,  general  house  cleaning
Intruder  alarm  system  and  its  maintenance
Hygiene  costs  (WC,  materials,  disposal  and  ventilation)
Gardening  as  well  as  maintenance of the outside installations, including the
replacement  of  plants  and  trees
Lighting  costs
Chimney  cleaning
Costs  of  water supply, in particular costs of water consumption, basic charges
and  the  meter  rent,  current  costs  of the use of intermediate meters (incl.
gauging  fees),  costs  of  operation  and maintenance of the house water supply
system.
Building,  property  and  liability  insurance
Caretaker  and  house  inspection
Building  and  glass  cleaning
Winter  service
Guarding  of  the  building
Maintenance  of  doors  and  windows
Fire  protection  and  maintenance,  inc.  fire  extinguishers

Further operating and maintenance costs of all above and non mentioned technical
installations  of  the  building,  in particular parking installations, entrance
doors,  barrier  systems,  ventilation  and  air-conditioning systems, emergency
power  units and illumination, bell and intercom systems, smoke control systems,
sprinkler  systems, fire alarm systems as well as any other security systems and
hot-water  supply  systems.

2.     The  advance  on  operating  and  ancillary  expenses (see   10) shall be
accounted  for  annually.  The Tenant is entitled to inspect the books within an
appropriate period after the receipt of the account.  - In case of a move of the
Tenant  during the accounting period, the allocation shall be made upon the next
regular  accounting for the remaining time of lease compared with the accounting
period.

  14     MAINTENANCE  OF  THE  ROOMS

1.     Any  damage  on  or  inside  the building and in the leased rooms must be
immediately  reported  to  the Landlord or its agent. The Tenant shall be liable
for  further  damage  caused  by  delayed  notification.

2.     The  Tenant  shall  be  liable  to  the Landlord for any damage caused by
culpable  failure  to  exercise  the  proper  care  incumbent  on the Tenant, in
particular  if  supply  and sewerage lines, toilets, heating installations, etc.
are  improperly  treated,  the  rooms are not sufficiently ventilated, heated or
protected  against  frost. Line clogging up to the main pipe shall be removed by
the  Tenant  at  its  expense  in  any  case.

<PAGE>

3.     In  the  same  manner, the Tenant shall be liable for any damage culpably
caused by its members, employees, subtenants, visitors, suppliers and craftsmen.

4.     Any damaged panes of glass and mirrors shall be replaced by the Tenant at
its  expense  in  any  case.  The Landlord assigns claims against culpable third
parties,  if any, to the Tenant. The Landlord shall not be obliged, but entitled
to insure all panes of glass and mirrors. The costs of such insurance, including
subsequent  insurance,  shall  be  borne  by  the  Tenant.

5.     Any  germination  of the leased property must be removed by the Tenant at
its  expense.  The  same  applies  to  any  free  spaces  leased  or  used.

6.     Minor maintenance/repairs shall be carried out by the party obliged (  10
Subsec.  8)  at  its  expense,  unless the damage was caused by the respectively
other  party.  Minor  maintenance/repairs  include the repair of minor damage as
well  as  the maintenance of lines and installations for water, electricity, gas
and  heating, of sanitary facilities, locks of windows, doors, shutters, blinds,
awnings  and  similar  installations.

7.     The  Tenant  must immediately fix any damage that its is responsible for.
If  the  Tenant  fails to comply with that obligation even within an appropriate
period  after receiving a respective notice, the Landlord can have the necessary
work  performed  at  the Tenant's expense. In case of imminent danger or unknown
whereabouts  of  the Tenant, a written notice and the granting of a period shall
not  be  required.

8.     The  tenant expressly indemnifies the Landlord against any liability with
regard  to  the leased property, unless such liability is culpably caused by the
Landlord.

  15     END  OF  THE  TERM  OF  LEASE

At  the  end of the term of lease, the Tenant must hand the leased rooms over to
the Landlord in a completely cleared, clean and freshly renovated condition. The
walls  shall  be  painted  uniformly  in  the  colour  type  Taiga 18. All keys,
including  any  additionally purchased keys, must be handed over to the Landlord
without  claim  for  compensation.  Otherwise, the Landlord shall be entitled to
have  the  leased  rooms opened, cleaned and painted and have new locks and keys
made  at  the  Tenant's  expense.

  16     OTHER  STIPULATIONS

1.     Landlord  and/or  Tenant  shall be jointly and severally liable as far as
they  are  formed by several persons. A notice of the Landlord shall be regarded
as  effective  when  it  is  given  to  one  of  the  Tenants.

2.     Should  any  provision  of  this Contract be or become legally invalid in
part or as a whole, this shall not affect the validity of the remaining parts of
the  contract. The contracting parties undertake to newly agree upon any invalid
provisions  in  a  legally  perfect  form  upon  the request of the other party.

3.     Any alterations of or additions to this Contract must be made in writing.

4.     The  place  of  performance  and  of  jurisdiction  is  Witten.

  17     PAYMENT  OF  RENT  AND  ANCILLARY  COSTS

Rent and ancillary costs shall be paid monthly in advance, not later than by the
3rd  working  day of the respective month, free of charge, to the Landlord or to
the  person  or  body  authorized  by  the  Landlord  to  receive  it.

     RENT  AND  ANCILLARY  COSTS  SHALL  BE  PAID  INTO  THE  ACCOUNT  NO. 49163
     AT  STADTSPARKASSE  WITTEN  (BANK  CODE  NO.  452  500  35)

The  timeliness  of the payment does not depend on the date of transmission, but
on  the  date  of  receipt  of  the  money.

In  case of late payment, the Landlord shall be entitled to charge dunning costs
to  an  amount  of  DM  50.00  per  dunning  notice, notwithstanding any default
interest.

<PAGE>
  18     LANDLORD'S  LIEN  -  PROVISION  OF  SECURITY

1.     The  Tenant declares that the items brought in upon moving into the rooms
are  its  free  property  and  that  they  are  not  seized  or  pledged,

     with  the  exception  of  the  following  items:    NONE

2.     The  Tenant  is  obliged  to  immediately  inform  the  Landlord about an
attachment  of  items  brought  in,  indicating  the  bailiff  and the attaching
creditor.

3.     Provision  of  security

     The  Tenant  HAS  ALREADY provided the Landlord with the a security for the
performance  of  its  obligations
     and/or for the payment of claims for damages to the amount of 2 monthly net
rent  payments

4.     From  the  date  of  receipt  of  the security on, the Landlord shall pay
interest  on  it at the usual rate for saving deposits with three months' period
of  notice.  -  The  interest shall increase the security. The security shall be
paid  before the leased rooms are handed over. - The security can be replaced by
a  bank  guarantee  at  any  time.

5.     The  guarantee,  together  with  the  interest, shall be paid back to the
Tenant  upon  termination of the lease relationship, provided it is certain that
there  are  no  claims  against  the  Tenant.

6.     The  rent  shall  remain  unchanged  until  31  March  2003.

  19     ADVERTISING  MEASURES  /  OUTDOOR  ADVERTISING

     The Tenant is entitled to fix advertising signs to the following areas:  as
agreed

     In  case  there exist or are installed collective sign carriers, the Tenant
shall  be  obliged  to use such systems and assume     pro-rata costs. (see also
the  House  Rules).

  20     PROTECTION  AGAINST  COMPETITION

     PROTECTION  OF  THE  TENANT  AGAINST  COMPETITION  IS  EXCLUDED.

  21     FURTHER  PROVISIONS

1.     In  performing  its  business  activities,  the  Tenant  must observe all
applicable  regulations  with  regard  to  environmental  protection.

2.     The  agreements  included in this Lease Contract, in particular the House
Rules,  are  essential  parts  of  this  Contract.

3.     Every  Tenant  is  jointly and severally liable for all obligations under
this  Lease  Contract.

4.     The  additional  agreements  of 09 April 1998 and 10 November 1998 to the
Lease  Contract  remain  in  force.

Witten,  13  April  2000                         Witten,  06  June  2000

/signature/                                      /signature/
RESEARCH  AND  DEVELOPMENT  CENTRE
FEZ  WITTEN  GMBH                                SANGUIBIOTECH  AG
 (Landlord)                                      (Tenant)

                    I HEREBY CERTIFY THAT THIS IS A TRUE AND
                      COMPLETE TRANSLATION OF THE PRESENTED
                        GERMAN DOCUMENT. THIS TRANSLATION
                    COMPRISES 1 PAGES (including this page).

                              Berlin, 27 July 2000

                                  Jochen Wendt
         Graduate Interpreter/Translator for German, English, Portuguese
        Generally Sworn Interpreter for the Courts and Notaries of Berlin

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