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                                                                    Exhibit 10.5

                        FORM OF INDEMNIFICATION AGREEMENT

     This Agreement (the "Agreement"), made and entered into as of this __th day
of________, 20__ by and between PICIS, Inc., a Delaware corporation (the
"Company"), and _____________ (the "Indemnitee"):

     WHEREAS, it is essential to the Company that it be able to retain and
attract as directors the most capable persons available;

     WHEREAS, increased corporate litigation has subjected directors to
litigation risks and expenses, and the limitations on the availability of
directors and officers liability insurance have made it increasingly difficult
for the Company to attract and retain such persons;

     WHEREAS, the Company's By-Laws (the "By-Laws") require it to indemnify its
directors to the fullest extent permitted by law and permit it to make other
indemnification arrangements and agreements;

     WHEREAS, the Company desires to provide Indemnitee with specific
contractual assurance of Indemnitee's rights to full indemnification against
litigation risks and expenses (regardless, among other things, of any amendment
to or revocation of the Company's Certificate of Incorporation (the "Certificate
of Incorporation") or By-Laws or any change in the ownership of the Company or
the composition of its Board of Directors); and

     WHEREAS, the Company intends that this Agreement provide Indemnitee with
greater protection than that which is provided by the By-Laws.

     NOW, THEREFORE, in consideration of the promises and the covenants
contained herein, the Company and Indemnitee do hereby covenant and agree as
follows:

     1.   DEFINITIONS.

          (a)     "Corporate Status" describes the status of a person who is
          serving or has served (i) as a director of the Company, (ii) in any
          capacity with respect to any employee benefit plan of the Company, or
          (iii) as a director, partner, trustee, officer, employee, or agent of
          any other Entity at the request of the Company. For purposes of
          subsection (iii) of this Section 1(a), if Indemnitee is serving or has
          served as a director, partner, trustee, officer, employee or agent of
          a Subsidiary, Indemnitee shall be deemed to be serving at the request
          of the Company.

          (b)     "Entity" shall mean any corporation, partnership, limited
          liability company, joint venture, trust, foundation, association,
          organization or other legal entity.

          (c)     "Expenses" shall mean all fees, costs and expenses incurred by
          Indemnitee in connection with any Proceeding (as defined below),
          including, without limitation, attorneys' fees, disbursements and
          retainers (including, without limitation, any such fees, disbursements
          and retainers incurred by Indemnitee

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          pursuant to Sections 10 and 11(c) of this Agreement), fees and
          disbursements of expert witnesses, private investigators and
          professional advisors (including, without limitation, accountants and
          investment bankers), court costs, transcript costs, fees of experts,
          travel expenses, duplicating, printing and binding costs, telephone
          and fax transmission charges, postage, delivery services, secretarial
          services, and other disbursements and expenses.

          (d)     "Indemnifiable Expenses," "Indemnifiable Liabilities" and
          "Indemnifiable Amounts" shall have the meanings ascribed to those
          terms in Section 3(a) below.

          (e)     "Liabilities" shall mean judgments, damages, liabilities,
          losses, penalties, excise taxes, fines and amounts paid in settlement.

          (f)     "Proceeding" shall mean any threatened, pending or completed
          claim, action, suit, arbitration, alternate dispute resolution
          process, investigation, administrative hearing, appeal, or any other
          proceeding, whether civil, criminal, administrative, arbitrative or
          investigative, whether formal or informal, including a proceeding
          initiated by Indemnitee pursuant to Section 10 of this Agreement to
          enforce Indemnitee's rights hereunder.

          (g)     "Subsidiary" shall mean any corporation, partnership, limited
          liability company, joint venture, trust or other Entity of which the
          Company owns (either directly or through or together with another
          Subsidiary of the Company) either (i) a general partner, managing
          member or other similar interest or (ii) (A) 50% or more of the voting
          power of the voting capital equity interests of such corporation,
          partnership, limited liability company, joint venture or other Entity,
          or (B) 50% or more of the outstanding voting capital stock or other
          voting equity interests of such corporation, partnership, limited
          liability company, joint venture or other Entity.

     2.   SERVICES OF INDEMNITEE. In consideration of the Company's covenants
and commitments hereunder, Indemnitee agrees to serve or continue to serve as a
director of the Company. However, this Agreement shall not impose any obligation
on Indemnitee or the Company to continue Indemnitee's service to the Company
beyond any period otherwise required by law or by other agreements or
commitments of the parties, if any.

     3.   AGREEMENT TO INDEMNIFY. The Company agrees to indemnify Indemnitee as
follows:

          (a)     PROCEEDINGS OTHER THAN BY OR IN THE RIGHT OF THE COMPANY.
          Subject to the exceptions contained in Section 4 below, if Indemnitee
          was or is a party or is threatened to be made a party to any
          Proceeding (other than an action by or in the right of the Company) by
          reason of Indemnitee's Corporate Status, Indemnitee shall be
          indemnified by the Company against all Expenses and Liabilities
          incurred or paid by Indemnitee in connection with such Proceeding
          (referred to herein as

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          "Indemnifiable Expenses" and "Indemnifiable Liabilities,"
          respectively, and collectively as "Indemnifiable Amounts").

          (b)     PROCEEDINGS BY OR IN THE RIGHT OF THE COMPANY. Subject to the
          exceptions contained in Section 4 below, if Indemnitee was or is a
          party or is threatened to be made a party to any Proceeding by or in
          the right of the Company by reason of Indemnitee's Corporate Status,
          Indemnitee shall be indemnified by the Company against all
          Indemnifiable Expenses.

          (c)     CONCLUSIVE PRESUMPTION REGARDING STANDARD OF CARE. In making
          any determination required to be made under Delaware law with respect
          to entitlement to indemnification hereunder, the person, persons or
          entity making such determination shall presume that Indemnitee is
          entitled to indemnification under this Agreement if Indemnitee
          submitted a request therefor in accordance with Section 5 of this
          Agreement, and the Company shall have the burden of proof to overcome
          that presumption in connection with the making by any person, persons
          or entity of any determination contrary to that presumption.

     4.   INSURANCE PROCEEDS. Indemnitee shall be entitled to indemnification
under Sections 3(a) and 3(b) above in all circumstances other than with respect
to any specific claim, issue or matter involved in the Proceeding out of which
Indemnitee's claim for indemnification has arisen in which it has been finally
adjudicated by a court of competent jurisdiction that, in connection with such
specific claim, issue or matter, Indemnitee acted (i) with willful misconduct,
or (ii) knowing violation of criminal law. In addition, to the extent payment is
actually made to the Indemnitee under a valid and collectible insurance policy
in respect of Indemnifiable Amounts in connection with such specific claim,
issue or matter, Indemnitee shall not be entitled to payment of Indemnifiable
Amounts hereunder except in respect of any excess beyond the amount of payment
under such insurance.

     5.   PROCEDURE FOR PAYMENT OF INDEMNIFIABLE AMOUNTS. Indemnitee shall
submit to the Company a written request specifying the Indemnifiable Amounts for
which Indemnitee seeks payment under Section 3 of this Agreement and the basis
for the claim. The Company shall pay such Indemnifiable Amounts to Indemnitee
within sixty (60) calendar days of receipt of the request. At the request of the
Company, Indemnitee shall furnish such documentation and information as are
reasonably available to Indemnitee and necessary to establish that Indemnitee is
entitled to indemnification hereunder.

     6.   INDEMNIFICATION FOR EXPENSES OF A PARTY WHO IS WHOLLY OR PARTLY
SUCCESSFUL. Notwithstanding any other provision of this Agreement, and without
limiting any such provision, to the extent that Indemnitee is, by reason of
Indemnitee's Corporate Status, a party to and is successful, on the merits or
otherwise, in any Proceeding, Indemnitee shall be indemnified against all
Expenses reasonably incurred by Indemnitee or on Indemnitee's behalf in
connection therewith. If Indemnitee is not wholly successful in such Proceeding
but is successful, on the merits or otherwise, as to one or more but less than
all claims, issues or matters in such Proceeding, the Company shall indemnify
Indemnitee against all Expenses reasonably incurred

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by Indemnitee or on Indemnitee's behalf in connection with each successfully
resolved claim, issue or matter. For purposes of this Agreement, the termination
of any claim, issue or matter in such a Proceeding by dismissal, with or without
prejudice, by reason of settlement, judgment, order or otherwise, shall be
deemed to be a successful result as to such claim, issue or matter.

     7.   EFFECT OF CERTAIN RESOLUTIONS. Neither the settlement or termination
of any Proceeding nor the failure of the Company to award indemnification or to
determine that indemnification is payable shall create a presumption that
Indemnitee is not entitled to indemnification hereunder. In addition, the
termination of any proceeding by judgment, order, settlement, conviction, or
upon a plea of nolo contendere or its equivalent shall not create a presumption
that Indemnitee did not act in good faith and in a manner which Indemnitee
reasonably believed to be in or not opposed to the best interests of the Company
or, with respect to any criminal Proceeding, had reasonable cause to believe
that Indemnitee's action was unlawful.

     8.   AGREEMENT TO ADVANCE EXPENSES; UNDERTAKING. The Company shall advance
all Expenses incurred by or on behalf of Indemnitee in connection with any
Proceeding, including a Proceeding by or in the right of the Company, in which
Indemnitee is involved by reason of such Indemnitee's Corporate Status within
thirty (30) calendar days after the receipt by the Company of a written
statement from Indemnitee requesting such advance or advances from time to time,
whether prior to or after final disposition of such Proceeding. To the extent
required by Delaware law, Indemnitee hereby undertakes to repay any and all of
the amount of Indemnifiable Expenses paid to Indemnitee if it is finally
determined by a court of competent jurisdiction that Indemnitee is not entitled
under this Agreement to indemnification with respect to such Expenses. This
undertaking is an unlimited general obligation of Indemnitee.

     9.   PROCEDURE FOR ADVANCE PAYMENT OF EXPENSES. Indemnitee shall submit to
the Company a written request specifying the Indemnifiable Expenses for which
Indemnitee seeks an advancement under Section 8 of this Agreement, together with
documentation evidencing that Indemnitee has incurred such Indemnifiable
Expenses (which shall include invoices received by Indemnitee in connection with
such Indemnifiable Expenses but, in the case of invoices in connection with
legal services, any reference to legal work performed or to expenditures made
that would cause Indemnitee to waive any privilege accorded by applicable law
shall not be included with the invoice). Payment of Indemnifiable Expenses under
Section 8 shall be made no later than thirty (30) calendar days after the
Company's receipt of such request.

     10.  REMEDIES OF INDEMNITEE.

          (a)     RIGHT TO PETITION COURT. In the event that Indemnitee makes a
          request for payment of Indemnifiable Amounts under Sections 3 and 5
          above or a request for an advancement of Indemnifiable Expenses under
          Sections 8 and 9 above and the Company fails to make such payment or
          advancement in a timely manner pursuant to the terms of this
          Agreement, Indemnitee may petition the Delaware Chancery Court to
          enforce the Company's obligations under this Agreement.

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          (b)     BURDEN OF PROOF. In any judicial proceeding brought under
          Section 10(a) above, the Company shall have the burden of proving that
          Indemnitee is not entitled to payment of Indemnifiable Amounts
          hereunder.

          (c)     EXPENSES. The Company agrees to reimburse Indemnitee in full
          for any Expenses incurred by Indemnitee in connection with
          investigating, preparing for, litigating, defending or settling any
          action brought by Indemnitee under Section 10(a) above, or in
          connection with any claim or counterclaim brought by the Company in
          connection therewith, if Indemnitee is successful in whole or in part
          in connection with any such action.

          (d)     FAILURE TO ACT NOT A DEFENSE. The failure of the Company
          (including its Board of Directors or any committee thereof,
          independent legal counsel, or stockholders) to make a determination
          concerning the permissibility of the payment of Indemnifiable Amounts
          or the advancement of Indemnifiable Expenses under this Agreement
          shall not be a defense in any action brought under Section 10(a)
          above, and shall not create a presumption that such payment or
          advancement is not permissible.

     11.  DEFENSE OF THE UNDERLYING PROCEEDING.

          (a)     NOTICE BY INDEMNITEE. Indemnitee agrees to notify the Company
          promptly upon being served with any summons, citation, subpoena,
          complaint, indictment, information, or other document relating to any
          Proceeding that may result in the payment of Indemnifiable Amounts or
          the advancement of Indemnifiable Expenses hereunder; provided,
          however, that the failure to give any such notice shall not disqualify
          Indemnitee from the right, or otherwise affect in any manner any right
          of Indemnitee, to receive payments of Indemnifiable Amounts or
          advancements of Indemnifiable Expenses unless the Company's ability to
          defend in such Proceeding is materially and adversely prejudiced
          thereby.

          (b)     DEFENSE BY COMPANY. Subject to the provisions of the last
          sentence of this Section 11(b) and of Section 11(c) below, the Company
          shall have the right to defend Indemnitee in any Proceeding that may
          give rise to the payment of Indemnifiable Amounts hereunder; provided,
          however that the Company shall notify Indemnitee of any such decision
          to defend within thirty (30) calendar days of receipt of notice of any
          such Proceeding under Section 11(a) above. The Company shall not,
          without the prior written consent of Indemnitee, consent to the entry
          of any judgment against Indemnitee or enter into any settlement or
          compromise that (i) includes an admission of fault of Indemnitee or
          (ii) does not include, as an unconditional term thereof, the full
          release of Indemnitee from all liability in respect of such
          Proceeding, which release shall be in form and substance reasonably
          satisfactory to Indemnitee. This Section 11(b) shall not apply to a
          Proceeding brought by Indemnitee under Section 10(a) above or pursuant
          to Section 19 below.

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          (c)     INDEMNITEE'S RIGHT TO COUNSEL. Notwithstanding the provisions
          of Section 11(b) above, if in a Proceeding to which Indemnitee is a
          party by reason of Indemnitee's Corporate Status, (i) Indemnitee
          reasonably concludes that he or she may have separate defenses or
          counterclaims to assert with respect to any issue which may not be
          consistent with the position of other defendants in such Proceeding,
          (ii) a conflict of interest or potential conflict of interest exists
          between Indemnitee and the Company, or (iii) if the Company fails to
          assume the defense of such proceeding in a timely manner, Indemnitee
          shall be entitled to be represented by separate legal counsel of
          Indemnitee's choice at the expense of the Company. In addition, if the
          Company fails to comply with any of its obligations under this
          Agreement or in the event that the Company or any other person takes
          any action to declare this Agreement void or unenforceable, or
          institutes any action, suit or proceeding to deny or to recover from
          Indemnitee the benefits intended to be provided to Indemnitee
          hereunder, Indemnitee shall have the right to retain counsel of
          Indemnitee's choice, at the expense of the Company, to represent
          Indemnitee in connection with any such matter.

     12.  REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company hereby
represents and warrants to Indemnitee as follows:

          (a)     AUTHORITY. The Company has all necessary power and authority
          to enter into, and be bound by the terms of, this Agreement, and the
          execution, delivery and performance of the undertakings contemplated
          by this Agreement have been duly authorized by the Company.

          (b)     ENFORCEABILITY. This Agreement, when executed and delivered by
          the Company in accordance with the provisions hereof, shall be a
          legal, valid and binding obligation of the Company, enforceable
          against the Company in accordance with its terms, except as such
          enforceability may be limited by applicable bankruptcy, insolvency,
          moratorium, reorganization or similar laws affecting the enforcement
          of creditors' rights generally.

     13.  INSURANCE. The Company shall, from time to time, make the good faith
determination whether or not it is practicable for the Company to obtain and
maintain a policy or policies of insurance with a reputable insurance company
providing the Indemnitee with coverage for losses from wrongful acts. For so
long as Indemnitee shall remain a director of the Company and with respect to
any such prior service, in all policies of director and officer liability
insurance, Indemnitee shall be named as an insured in such a manner as to
provide Indemnitee the same rights and benefits as are accorded to the most
favorably insured of the Company's officers and directors. Notwithstanding the
foregoing, the Company shall have no obligation to obtain or maintain such
insurance if the Company determines in good faith that such insurance is not
reasonably available, if the premium costs for such insurance are
disproportionate to the amount of coverage provided, or if the coverage provided
by such

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insurance is limited by exclusions so as to provide an insufficient benefit. The
Company shall promptly notify Indemnitee of any good faith determination not to
provide such coverage.

     14.  CONTRACT RIGHTS NOT EXCLUSIVE. The rights to payment of Indemnifiable
Amounts and advancement of Indemnifiable Expenses provided by this Agreement
shall be in addition to, but not exclusive of, any other rights which Indemnitee
may have at any time under applicable law, the Company's Certificate of
Incorporation or By-laws, or any other agreement, vote of stockholders or
directors (or a committee of directors), or otherwise, both as to action in
Indemnitee's official capacity and as to action in any other capacity as a
result of Indemnitee's serving as a director of the Company.

     15.  SUCCESSORS. This Agreement shall be (a) binding upon all successors
and assigns of the Company (including any transferee of all or a substantial
portion of the business, stock and/or assets of the Company and any direct or
indirect successor by merger or consolidation or otherwise by operation of law)
and (b) binding on and shall inure to the benefit of the heirs, personal
representatives, executors and administrators of Indemnitee. This Agreement
shall continue for the benefit of Indemnitee and such heirs, personal
representatives, executors and administrators after Indemnitee has ceased to
have Corporate Status.

     16.  SUBROGATION. In the event of any payment of Indemnifiable Amounts
under this Agreement, the Company shall be subrogated to the extent of such
payment to all of the rights of contribution or recovery of Indemnitee against
other persons, and Indemnitee shall take, at the request of the Company, all
reasonable action necessary to secure such rights, including the execution of
such documents as are necessary to enable the Company to bring suit to enforce
such rights.

     17.  CHANGE IN LAW. To the extent that a change in Delaware law (whether by
statute or judicial decision) shall permit broader indemnification or
advancement of expenses than is provided under the terms of the By-laws and this
Agreement, Indemnitee shall be entitled to such broader indemnification and
advancements, and this Agreement shall be deemed to be amended to such extent.

     18.  SEVERABILITY. Whenever possible, each provision of this Agreement
shall be interpreted in such a manner as to be effective and valid under
applicable law, but if any provision of this Agreement, or any clause thereof,
shall be determined by a court of competent jurisdiction to be illegal, invalid
or unenforceable, in whole or in part, such provision or clause shall be limited
or modified in its application to the minimum extent necessary to make such
provision or clause valid, legal and enforceable, and the remaining provisions
and clauses of this Agreement shall remain fully enforceable and binding on the
parties.

     19.  INDEMNITEE AS PLAINTIFF. Except as provided in Section 10(c) of this
Agreement and in the next sentence, Indemnitee shall not be entitled to payment
of Indemnifiable Amounts or advancement of Indemnifiable Expenses with respect
to any Proceeding brought by Indemnitee against the Company, any Entity which it
controls, any director or officer thereof, or any third party, unless the Board
of Directors of the Company has consented to the initiation of

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such Proceeding. This Section shall not apply to counterclaims or affirmative
defenses asserted by Indemnitee in an action brought against Indemnitee.

     20.  MODIFICATIONS AND WAIVER. Except as provided in Section 17 above with
respect to changes in Delaware law which broaden the right of Indemnitee to be
indemnified by the Company, no supplement, modification or amendment of this
Agreement shall be binding unless executed in writing by each of the parties
hereto. No waiver of any of the provisions of this Agreement shall be deemed or
shall constitute a waiver of any other provisions of this Agreement (whether or
not similar), nor shall such waiver constitute a continuing waiver.

     21.  GENERAL NOTICES. All notices, requests, demands and other
communications hereunder shall be in writing and shall be deemed to have been
duly given (a) when delivered by hand, (b) when transmitted by facsimile and
receipt is acknowledged, or (c) if mailed by certified or registered mail with
postage prepaid, on the third business day after the date on which it is so
mailed:

          (i)     If to Indemnitee, to:

                  ______________________

                  ______________________

                  ______________________

                  ______________________

          (ii)    If to the Company, to:

                  PICIS, Inc.
                  100 Quannapowitt Pkwy Suite 405
                  Wakefield, MA 01880
                  Facsimile: (781) 557-3140

or to such other address as may have been furnished in the same manner by any
party to the others.

     22.  GOVERNING LAW. This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware without regard to its rules of
conflict of laws.

                            [signature page follows]

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     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the day and year first above written.

                                        PICIS, INC.

                                        By:
                                           ----------------------------------
                                           Name:
                                           Title:

                                        INDEMNITEE

                                        -------------------------------------

                  [Signature Page to Indemnification Agreement]<Page>

                                                                    Exhibit 10.6

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                 (AMENDED AND RESTATED EFFECTIVE JUNE 27, 2006)

     1. OBJECTIVES. The PICIS, Inc. 2000 Stock Option Plan is designed to
attract and retain certain selected officers, key employees, non-employee
directors and consultants whose skills and talents are important to the
Company's operations, and reward them for making major contributions to the
success of the Company. These objectives are accomplished by making awards under
the Plan, thereby providing Participants with a proprietary interest in the
growth and performance of the Company.

     2. DEFINITIONS.

            (a) "Award" shall mean the grant of a Stock Option to a Plan
     Participant pursuant to such terms, conditions, performance requirements,
     and limitations as the Committee may establish in order to fulfill the
     objectives of the Plan.

            (b) "Award Agreement" shall mean an agreement between PICIS, Inc.
     and a Participant that sets forth the terms, conditions, performance
     requirements, and limitations applicable to an Award.

            (c) "Board" shall mean the Board of Directors of PICIS, Inc.

            (d) "Cause shall mean, with respect to any Participant, one of the
     following:

                     (i)  Cause shall have the meaning assigned to such term in
            an employment agreement in effect between the Company and a
            Participant; or

                     (ii) If 2(d)(i), above, is not applicable, Cause shall have
            the meaning assigned to that term under any statute which governs a
            Participant's employment with the Company; or

                     (iii) If neither 2(d)(i) nor 2(d)(ii), above, are
            applicable, Cause shall mean termination of a Participant's
            employment with the Company or service as a director for (a) any
            failure of the Participant to substantially perform his duties with
            the Company (other than by reason of illness) which occurs after the
            Company has delivered to the Participant a demand for performance
            which specifically identifies the manner in which the Company
            believes the Participant has failed to perform his duties, and the
            Participant fails to resume performance of his duties on a
            continuous basis within 14 days after receiving such demand, (b) the
            commission by the Participant of any act of dishonesty or disloyalty
            involving the Company or its business, or (c) the conviction of the
            Participant of a felony or misdemeanor which, in the reasonable
            judgment of the Committee, is

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            substantially related to the employee's position with the Company or
            substantially impairs the Participant's ability to perform his
            duties with the Company.

            (e) "Change in Control" shall mean any of the following events:

                     (i)  the acquisition by an individual, entity or group
            (within the meaning of Section 13(d)(2) of the Securities Exchange
            Act of 1934, as amended (the "Exchange Act")), (a "Person"), after
            the date hereof, of beneficial ownership (within the meaning of Rule
            13d-3 promulgated under the Exchange Act) of 35% or more of either
            (a) the then outstanding shares of common stock of PICIS, Inc. (the
            "Outstanding Company Common Stock") plus the then outstanding shares
            of preferred stock of PICIS, Inc., on an as converted basis or (b)
            the combined voting power of the then outstanding voting securities
            of PICIS, Inc. entitled to vote generally in the election of
            directors (the "Outstanding Company Voting Securities"); provided,
            however, that for purposes of this subsection (i), the following
            acquisitions shall not constitute a Change of Control: (a) any
            acquisition directly from PICIS, Inc., (b) any acquisition by the
            Company, (c) any acquisition by any employee benefit plan (or
            related trust) sponsored or maintained by the Company, or (d) any
            acquisition by any corporation pursuant to a transaction which
            complies with clauses (a), (b) and (c) of subsection (iii) of this
            Section 2(e); and provided, further, that for purposes of this
            subsection and subsection (iii), below, none of the stockholders of
            PICIS, Inc., and/or any person who becomes a stockholder of PICIS,
            Inc. in the private placement being conducted by PICIS, Inc.,
            concurrently herewith shall be aggregated and treated as members of
            a group constituting a single "Person"; or

                     (ii) individuals who, as of the date hereof, constitute the
            Board (the "Incumbent Board") cease for any reason to constitute at
            least a majority of the Board; provided, however, that any
            individual becoming a director subsequent to the date hereof whose
            election, or nomination for election by PICIS, Inc.'s shareholders,
            was approved by a vote of at least a majority of the directors then
            constituting the Incumbent Board shall be considered as though such
            individual were a member of the Incumbent Board, but excluding, for
            this purpose, any such individual whose initial assumption of office
            occurs as a result of an actual or threatened election contest with
            respect to the election or removal of directors or other actual or
            threatened solicitation of proxies or consents by or on behalf of a
            person other than the Board; or

                     (iii) consummation of a reorganization, merger or
            consolidation or sale or other disposition of all or substantially
            all of the assets of the Company for which approval of the
            shareholders of PICIS, Inc. is required (a "Business Combination"),
            in each case, unless, immediately following such Business
            Combination, (a) all or substantially all of the individuals and
            entities who were the beneficial owners, respectively, of the
            Outstanding Company Common Stock and Outstanding Company Voting
            Securities immediately prior to such Business

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            Combination beneficially own, directly or indirectly, more than 60%
            of, respectively, the then outstanding shares of common stock and
            the combined voting power of the then outstanding voting securities
            entitled to vote generally in the election of directors, as the case
            may be, of the corporation resulting from such Business Combination
            (including, without limitation, a corporation which as a result of
            such transaction owns PICIS, Inc. or all or substantially all of the
            Company's assets either directly or through one or more
            subsidiaries) in substantially the same proportions as their
            ownership, immediately prior to such Business Combination of the
            Outstanding Company Common Stock and Outstanding Company Voting
            Securities, as the case may be, (b) no Person (excluding any
            employee benefit plan (or related trust) of the Company or such
            corporation resulting from such Business Combination) beneficially
            owns, directly or indirectly, 35% or more of, respectively, the then
            outstanding common stock of the corporation resulting from such
            Business Combination or the combined voting power of the then
            outstanding voting securities of such corporation except to the
            extent that such ownership existed prior to the Business Combination
            and (c) at least a majority of the members of the Board of Directors
            of the corporation resulting from such Business Combination were
            members of the Incumbent Board at the time of the execution of the
            initial agreement, or of the action of the Board, providing for such
            Business Combination; or

                     (iv) approval by the shareholders of PICIS, Inc. of a
            complete liquidation or dissolution of PICIS, Inc.

     Notwithstanding the foregoing, in no event will an initial public offering
     of the stock of the Company constitute a Change in Control.

            (f) "Common Stock" shall mean the authorized and issued or unissued
     $.01 par value common stock of PICIS, Inc.

            (g) "Code" shall mean the Internal Revenue Code of 1986, as amended
     from time to time.

            (h) "Committee" shall mean the compensation committee of the Board
     which shall be comprised of at least two non-employee directors or, if
     there is no such committee, the Board.

            (i) "Company" shall mean PICIS, Inc. and its subsidiaries including
     subsidiaries of subsidiaries and partnerships and other business ventures
     in which PICIS, Inc. has a significant equity interest, as determined in
     the sole discretion of the Committee.

                                        3
<Page>

            (j) "Fair Market Value" shall mean, as of any date, the value of
     Common Stock determined as follows:

                     (i)  If the Common Stock is listed on any established stock
            exchange or national market system, its Fair Market Value shall be
            the closing sales price for such stock (or the closing bid, if no
            sales were reported) as quoted on such exchange or system for the
            last market trading day prior to the time of determination, as
            reported in THE WALL STREET JOURNAL or such other source as the
            Committee deems reliable.

                     (ii) If the Common Stock is regularly quoted by a
            recognized securities dealer but selling prices are not reported,
            its Fair Market Value shall be the mean between the high bid and low
            asked prices for the Common Stock on the last market trading day
            prior to the day of determination; or

                     (iii) In the absence of an established market for the
            Common Stock, the Fair Market Value thereof shall be determined in
            good faith by the Committee, with the Committee's determination
            being binding on the Company and the Participants for all purposes.

            (k) "Participant" shall mean a current or prospective employee,
     non-employee director, consultant or other person who provides services to
     the Company to whom an Award has been made under the Plan.

            (l) "Plan" shall mean the PICIS, Inc. 2000 Stock Option Plan.

            (m) "Retirement" shall mean termination of employment with the
     Company or service as a member of the Board on or after the attainment of
     age 65 or such other time as the Committee shall provide.

            (n) "Stock Option" shall mean a grant of a right to purchase a
     specified number of shares of Common Stock, the purchase price of which
     shall be determined by the Committee. A stock option may be in the form of
     a nonqualified stock option or an incentive stock option ("ISO"). A
     nonqualified stock option is an option that does not meet the criteria of
     an ISO. An ISO, in addition to being subject to applicable terms,
     conditions and limitations established by the Committee, complies with
     Section 422 of the Code which, among other limitations, provides that the
     aggregate Fair Market Value (determined at the time the option is granted)
     of Common Stock for which ISOs are exercisable for the first time by a
     Participant during any calendar year shall not exceed $100,000; that ISOs
     shall be priced at not less than 100% of the Fair Market Value on the date
     of the grant (110% in the case of a Participant who is a 10% shareholder of
     the Company within the meaning of Section 422 of the Code); and that ISOs
     shall be exercisable for a period of not more than ten years (five years in
     the case of a Participant who is a 10% shareholder of the Company).

                                        4
<Page>

     3. ELIGIBILITY. Current and prospective employees, non-employee
directors, consultants or other persons who provide services to the Company
eligible for an Award under the Plan are those who hold, or will hold, positions
of responsibility and whose performance, in the judgment of the Committee or the
management of the Company (if such responsibility is delegated pursuant to
Section 6 hereof), can have a significant effect on the success of the Company.
However, incentive stock options within the meaning of Section 422 of the Code
may only be issued to employees of the Company and its subsidiary corporations
within the meaning of Section 424(f) of the Code.

     4. COMMON STOCK AVAILABLE FOR AWARDS. Subject to adjustment as provided
in Section 14 hereof, the number of shares that may be issued under the Plan for
Awards during the term of the Plan is 3,731,300 shares of Common Stock, all of
which may be in the form of incentive stock options. Any shares subject to an
Award which are used, with the Company's consent, in settlement of tax
withholding obligations shall be deemed not to have been issued for purposes of
determining the maximum number of shares available for issuance under the Plan.
Likewise, if any Stock Option is exercised by tendering shares, either actually
or by attestation, to the Company as full or partial payment for such exercise
under this Plan, only the number of shares issued net of the shares tendered
shall be deemed issued for purposes of determining the maximum number of shares
available for issuance under the Plan. No individual shall be eligible to
receive Awards aggregating more than 300,000 shares of Common Stock reserved
under the Plan in any one calendar year, subject to adjustment as provided in
Section 13 hereof.

     5. ADMINISTRATION. The Plan shall be administered by the Committee, which
shall have full and exclusive power to interpret the Plan, to determine which
current and prospective employees, non-employee directors and consultants are
Plan Participants, to grant waivers of Award restrictions, to determine the
provisions of Award Agreements and to adopt such rules, regulations and
guidelines for carrying out the Plan as it may deem necessary or proper, all of
which powers shall be executed in the best interests of the Company and in
keeping with the objectives of the Plan. All decisions of the Committee shall be
final, conclusive and binding on all persons, including the Company,
Participants, and their estates and beneficiaries.

     6. DELEGATION OF AUTHORITY. Except to the extent prohibited by applicable
law or the applicable rules of a stock exchange, the Committee may delegate to
the chief executive officer and to other senior officers of the Company its
duties under the Plan pursuant to such conditions or limitations as the
Committee may establish. Any such delegation may be revoked by the Committee at
any time.

     7. AWARDS. The Committee shall set forth in the related Award Agreement
the terms, conditions, and limitations applicable to each Award including, but
not limited to, continuous service with the Company, and conditions under which
acceleration of vesting will occur.

     8. STOCK OPTION EXERCISE. The price at which shares of Common Stock may
be purchased under a Stock Option shall be paid in full at the time of the
exercise in cash or by any other means permitted by the Committee, including by
means of tendering shares of Common Stock, which have been held by the
Participant for more than six months and have not been used

                                        5
<Page>

within the prior six-month period to exercise an option, either directly or by
attestation, valued at Fair Market Value on the date of exercise, or any
combination thereof.

     9. TAX WITHHOLDING. The Company may defer making delivery with respect to
Common Stock obtained pursuant to the exercise of an Award hereunder until the
Participant has paid to the Company an amount equal to any income or employment
tax withholding amounts imposed on current or former employees as a result of
the exercise of the Award. If the Committee allows Common Stock to be used to
satisfy any such tax withholding obligations, such stock shall be valued based
on the Fair Market Value when the tax withholding is required to be made.

     10. AMENDMENT OR TERMINATION OF THE PLAN. The Board may, at any time, amend
or terminate the Plan; provided, however, that

            (a) subject to Section 13 hereof, no amendment or termination may,
     in the absence of written consent to the change by the affected Participant
     (or, if the Participant is not then living, the affected beneficiary),
     adversely affect the rights of any Participant or beneficiary under any
     Award granted under the Plan prior to the date such amendment is adopted by
     the Board; and

            (b) without further approval of the shareholders of the Company, no
     amendment shall increase the number of shares of Common Stock which may be
     delivered pursuant to Awards hereunder, except for increases resulting from
     Section 13 hereof.

     11. TERMINATION OF SERVICE. If the employment of a Participant terminates,
or a non-employee director no longer serves on the Board, all unvested Awards
shall immediately terminate and all vested but unexercised, deferred or unpaid
Awards shall terminate 90 days after such termination of employment or service,
except as provided in paragraphs 11 (a) and (b), below, and during such 90-day
period shall be exercisable only to the extent provided in the Award Agreement.
Notwithstanding the foregoing, the Committee may provide in an Award Agreement
that if a Participant's employment is terminated for Cause, to the extent the
Award is not effectively exercised or has not vested prior to such termination,
it shall lapse or be forfeited to the Company immediately upon termination. In
all events, an Award will not be exercisable after the end of its term as set
forth in the Award Agreement.

            (a) RETIREMENT. When a Participant's employment or service
     terminates as a result of Retirement, or early retirement with the consent
     of the Committee, the Committee (in the form of an Award Agreement or
     otherwise) may permit Awards to continue in effect beyond the date of
     Retirement, or early retirement, and/or the exercisability and vesting of
     any Award may be accelerated.

            (b) DEATH OR DISABILITY OF A PARTICIPANT.

                     (i)  In the event of a Participant's death, the
            Participant's estate or beneficiaries shall have a period of six (6)
            months (unless otherwise specified in his Award Agreement) within
            which to exercise any outstanding Award held by

                                        6
<Page>

            the Participant under such terms, and to the extent, as may be
            specified in the applicable Award Agreement. Rights to any such
            outstanding Awards shall pass by will or the laws of descent and
            distribution. Subject to subparagraph (iii) below, Awards so passing
            shall be exercised at such times and in such manner as if the
            Participant were living.

                     (ii) In the event a Participant is deemed by the Company to
            have suffered a long-term disability within the meaning of the
            long-term disability coverage which the Company provides to its
            employees, or if there is no such coverage, a total and permanent
            disability (a "Disability"), the Award shall be exercisable pursuant
            to the terms of the applicable Award Agreement and for a period of
            six (6) months (unless otherwise specified in his Award Agreement).
            Awards may be exercised by the Participant, if legally competent, or
            a legally designated guardian or representative if the Participant
            is legally incompetent by virtue of such Disability.

                     (iii) After the death or Disability of a Participant, the
            Committee may in its sole discretion at any time (1) terminate
            restrictions in Award Agreements and (2) accelerate any or all
            installments and rights.

                     (iv) In the event of uncertainty as to interpretation of or
            controversies concerning this paragraph (b) of Section 11, the
            Committee's determinations shall be binding and conclusive.

            (c) NO EMPLOYMENT RIGHTS. The Plan shall not confer upon any
     Participant any right with respect to continuation of employment by the
     Company or service on the Board, nor shall it interfere in any way with the
     right of the Company to terminate any Participant's employment or service
     on the Board at any time.

     12. NONASSIGNABILITY. Except as provided in subsection (b) of Section 11
and this Section 12, no Award under the Plan shall be assignable or
transferable, or exercisable by anyone other than the Participant to whom it was
granted. Notwithstanding the foregoing, the Committee (in the form of an Award
Agreement or otherwise) may permit Awards, other than incentive stock options
within the meaning of Section 422 of the Code, to be transferred to members of
the Participant's immediate family, to trusts for the benefit of the Participant
and/or such immediate family members, and to partnerships or other entities in
which the Participant and/or such immediate family members own all the equity
interests. For purposes of the preceding sentence, "immediate family" shall mean
a Participant's spouse, issue, and spouses of his issue.

     13. ADJUSTMENTS. In the event of any change in the outstanding Common Stock
of the Company by reason of a stock split, stock dividend, combination or
reclassification of shares, recapitalization, merger, or similar event, the
Committee may adjust proportionally (a) the number of shares of Common Stock (i)
reserved under the Plan, (ii) for which Awards may be granted to an individual
Participant, and (iii) covered by outstanding Awards; (b) the stock prices

                                        7
<Page>

related to outstanding Awards; and (c) the appropriate Fair Market Value and
other price determinations for such Awards. In the event of any other change
affecting the Common Stock or any distribution (other than normal cash
dividends) to holders of Common Stock, such adjustments as may be deemed
equitable by the Committee, including adjustments to avoid fractional shares,
shall be made to give proper effect to such event. In the event of a corporate
merger, consolidation, acquisition of property or stock, separation,
reorganization or liquidation, the Committee shall be authorized to issue or
assume Stock Options, whether or not in a transaction to which Section 424(a) of
the Code applies, by means of substitution of new Stock Options for previously
issued Stock Options or an assumption of previously issued Stock Options.

     14. NOTICE. Any notice to the Company required by any of the provisions of
the Plan shall be addressed to the director of finance of the Company in
writing, and shall become effective when it is received by his office.

     15. GOVERNING LAW. The Plan and all determinations made and actions taken
pursuant hereto shall be governed by the laws of the State of Delaware, without
giving effect to principles of conflicts of laws, and construed accordingly.

     16. EFFECTIVE AND TERMINATION DATES. The effective date of the Plan is June
9, 2000. The Plan shall terminate on June 8, 2010 subject to earlier termination
by the Board pursuant to Section 10, after which no Awards may be made under the
Plan, but any such termination shall not affect Awards then outstanding or the
authority of the Committee to continue to administer the Plan.

     17. OTHER BENEFIT AND COMPENSATION PROGRAMS. Payments and other benefits
received by a Participant pursuant to an Award shall not be deemed a part of
such Participant's regular, recurring compensation for purposes of the
termination, indemnity or severance pay law of any country and shall not be
included in, nor have any effect on, the determination of benefits under any
other employee benefit plan, contract or similar arrangement, unless the
Committee expressly determines otherwise.

     18. DISSOLUTION OR LIQUIDATION OF THE COMPANY. Should dissolution or
liquidation of the Company be envisaged, the Committee shall be entitled, at its
sole discretion, to authorize all Participants to exercise their Awards within a
period which it shall determine, exempting them from the provisions of their
Award Agreements pertaining to the exercise period of the Awards. All Awards not
exercised during such period shall lapse upon the expiration of such period. In
the absence of such authorization, any unvested Awards shall lapse upon the
occurrence of the dissolution or liquidation.

     19. MERGER, SPLIT-UP OR TRANSFER OF ASSETS OF THE COMPANY. In the event of
a merger or a split-up of the Company, or the sale of substantially all the
assets of the Company, the acquiring or transferee company, or one of its
affiliates, shall replace the Company as regards its obligations vis a vis the
Participants. In relation thereto, depending on the circumstances, it may be
provided that:

                                        8
<Page>

            (a) either the Awards will be exercisable for shares of the
     acquiring or transferee company, in which case the number and price of
     shares governed by the Awards shall be calculated on the basis of the
     exchange ratio applicable to the transaction.

            (b) or that each Award will be replaced by the acquiring or
     transferee company with an equivalent right. A right shall be deemed to be
     equivalent if it entitles its holder to the same compensation, regardless
     of the form thereof (shares, cash or otherwise), as that received by
     holders of Common Stock, it being specified that once the shareholders of
     the Company have been offered a choice of more than one form of
     compensation, the compensation to which the Participants shall be entitled
     shall be that which as been chosen by the holders of the majority of
     existing shares of Common Stock of the Company.

     However, as an alternative to the above-mentioned substitution of the
acquiring or transferee company for the Company, the Committee shall be entitled
to accelerate the vesting of all unvested Awards. In this case, the Committee
shall inform the Participants in writing that all of their Awards may be
exercised within a period of fifteen (15) days from the date of said notice and
that Awards not exercised within said period shall lapse.

                                        9
<Page>

                                   APPENDIX A

                  PROVISIONS APPLICABLE TO CALIFORNIA RESIDENTS

Notwithstanding anything in the Plan or any Award Agreement to the contrary, the
following provisions shall apply to any Award granted under the Plan to a
resident of the State of California made prior to a public offering of capital
stock of the Company that is effected pursuant to a registration statement filed
with, and declared effective by, the Securities and Exchange Commission under
the Securities Act of 1933, as amended, and only to the extent required by
applicable law and, in the event of any conflict or inconsistency between the
following provisions and the provisions otherwise appearing in the Plan, the
following provisions shall control, solely with respect to Stock Options or
other awards granted under the Plan to residents of the State of California:

1.   At no time shall the total number of shares of Company stock issuable upon
     exercise of all outstanding Stock Options granted pursuant to this Plan and
     the total number of shares provided for under any bonus or similar plan or
     agreement of the Company exceed the limitations set forth in Rule
     260.140.45 promulgated under the California Code, based on the number of
     shares of the Company which are outstanding at the time the calculation is
     made.

2.   The exercise price of a Stock Option granted to a California resident may
     not be less than 85% of the "fair value" (as defined by Rule 260.140.50
     promulgated under the California Code) of the Company's Common Stock at the
     time the Stock Option is granted (or 110% of the "fair value" in the case
     of any person who owns stock possessing more than 10% of the total combined
     voting power of all classes of stock of the Company or its parent or
     subsidiary corporations at the time of such grant).

3.   The exercise period of a Stock Option granted to a California resident
     shall be no longer than 120 months from the date the Stock Option is
     granted.

4.   The number of securities purchasable and the exercise price thereof under
     the Stock Options will be adjusted proportionately in the event of a stock
     split, reverse stock split, stock dividend, recapitalization, combination,
     reclassification or other distribution of the Company's equity securities
     without receipt of consideration by the Company, of or on the Company's
     class or series of securities underlying the Stock Option.

5.   A Stock Option granted to a California resident shall not be transferable,
     other than by will or the laws of descent and distribution, or as permitted
     by Rule 701 of the Securities Act of 1933, as amended.

6.   A Stock Option granted to a California resident shall become exercisable at
     the rate of at least 20% per year over 5 years from the date the Stock
     Option is granted, subject to reasonable conditions such as continued
     employment. However, in the case of a Stock Option granted to a California
     resident who is an officer, director, or consultant of the

                                       10
<Page>

     Company or any of its affiliates, the Stock Option may become fully
     exercisable, subject to reasonable conditions such as continued employment,
     at any time or during any period established by the Company.

7.   Unless employment is terminated for cause as defined by applicable law, the
     terms of the Plan or Award Agreement or a contract of employment, the right
     to exercise a Stock Option granted to a California resident in the event of
     termination of such Participant's employment (to the extent that such
     Participant is otherwise entitled to exercise on the date of termination of
     employment) shall terminate as follows:

        (a) At least 6 months from the date of termination if termination was
        caused by death or disability; or

        (b) At least 30 days from the date of termination if termination was
        caused by an event other than death or disability.

8.   The Plan shall terminate on the earlier of ten years after the date the
     Plan is adopted or the date the Plan is approved by the shareholders of the
     Company

9.   The Plan shall be available to California residents only if the
     shareholders of the Company approve the Plan within 12 months before or
     after the date the Plan is adopted. Any Stock Option exercised by a
     California resident before such stockholder approval is obtained shall be
     rescinded if such stockholder approval is not subsequently obtained and
     such shares shall not be counted in determining whether the required
     stockholder approval is obtained.

10.  Each California resident participating in the Plan will be provided with a
     copy of the Company's annual financial statements (which need not be
     audited) in accordance with Section 260.140.46 of Title 10 of the
     California Code of Regulations. The Company shall not be required to
     provide such statements to key employees whose duties with the Company
     assure access to equivalent information.

11.  The Company will comply with Section 260.140.1 of Title 10 of the
     California Code of Regulations with respect to the voting rights of Common
     Stock and similar equity securities.

12.  At the discretion of the Committee, the Company may reserve to itself
     and/or its assignee(s) in the Award Agreement a right to repurchase
     securities held by an Award recipient upon such Award recipient's
     termination of employment at any time within 90 days after such Award
     recipient's termination date (or in the case of securities issued upon
     exercise of a Stock Option after the termination date, within 90 days after
     the date of such exercise) for cash or cancellation of purchase money
     indebtedness, at:

        (a) no less than the Fair Market Value of such securities as of the date
        of the Award recipient's termination of employment, PROVIDED, that such
        right to repurchase securities terminates when the Company's securities
        have become publicly traded; or

        (b) the Award recipient's original purchase price, PROVIDED, that such
        right to repurchase securities at the original purchase price lapses at
        the rate of at least 20% of the securities

                                       11
<Page>

        per year over 5 years from the date the Stock Option is granted (without
        respect to the date the Stock Option was exercised or became
        exercisable).

        The securities held by an officer, director, manager or consultant of
        the Company or an affiliate may be subject to additional or greater
        restrictions.

13.  The Plan is intended to comply with Section 25102(o) of the California
     Corporations Code. Any provision of this Plan which is inconsistent with
     Section 25102(o), including without limitation any provision of this Plan
     that is more restrictive than would be permitted by Section 25102(o) as
     amended from time to time, shall, without further act or amendment by the
     Board, be reformed to comply with the provisions of Section 25102(o). If at
     any time the Committee determines that the delivery of Common Stock under
     the Plan is or may be unlawful under the laws of any applicable
     jurisdiction, or federal or state securities laws, the right to exercise a
     Stock Option or receive shares of Common Stock pursuant to a Stock Option
     shall be suspended until the Committee determines that such delivery is
     lawful. The Company shall have no obligation to effect any registration or
     qualification of the Common Stock under federal or state laws.

                                       12
<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART I

                         NOTICE OF GRANT OF STOCK OPTION

     We are pleased to inform you that you have been granted a Stock Option to
purchase shares of Common Stock of PICIS, Inc., subject to the terms and
conditions of the PICIS, Inc. 2000 Stock Option Plan (the "Plan") and of this
Award Agreement. Unless otherwise defined herein, all terms used in this Award
Agreement shall have the same meanings as set forth in the Plan.

     Award Number:

     Date of Award:

     Exercise price per share:

     Total number of shares:

     Total exercise price:

     1. INCENTIVE STOCK OPTIONS. It is intended that all or a portion of the
Stock Option that vests in any calendar year shall qualify as an incentive stock
option pursuant to Section 422 of the Code to the extent it meets the
requirements thereof, including the $100,000 per year limitation contained in
Code Section 422(d).

     2. VESTING SCHEDULE. The Stock Option granted pursuant to this Award will
vest according to the following schedule, PROVIDED, HOWEVER, that you must be
employed by the Company on each vesting date for that portion of the Stock
Option to vest:

<Table>
<Caption>
  Number of Shares of Common Stock                  Vesting Date
--------------------------------------------------------------------------------
<S>                                                 <C>

</Table>

<Page>

     3. ACCELERATED VESTING. If a Change in Control occurs while you are
employed by the Company and either (a) the company acquiring the assets or stock
of the Company does NOT assume the Company's obligations under this Award
Agreement in their totality (other than adjustments to the number of shares and
the exercise price which still maintain the economics of the Stock Option) as
provided in Section 19 of the Plan or (b) your employment is terminated by the
acquiring or transferee company after the Change in Control, any unvested
options will become immediately vested and exercisable upon the first to occur
of subparagraphs (a) or (b).

     4. EXPIRATION DATE. In all events, and notwithstanding anything herein
contained to the contrary, this Stock Option shall expire no later than DATE.

     By your signature and the signature of the Company's representative below,
you and the Company agree that the Stock Option which has been awarded to you
under this Award Agreement is subject to the terms and conditions of the Plan
which is attached hereto as Exhibit A. As provided in the Plan, you hereby agree
to accept as binding any decision of the Committee with respect to the
interpretation of the Plan and this Award Agreement, or any other matters
associated therewith. You further agree to notify the Company as soon as
possible upon any change in your residential address. By your signature below,
you certify that you do not hold more than 10% of the voting rights of any type
of securities issued by the Company, and that consequently the Stock Option
awarded pursuant to the Award Agreement may be considered an incentive stock
option, if all of the requirements of Code Section 422 are met.

     By your signature below, you acknowledge the confidential nature of the
grant made to you hereby, and you agree not to disclose to any person (other
than those members of the company's management charged with the administration
of the Plan and to your independent legal, tax and financial advisors provided
they abide by this paragraph) the number of shares subject to this Award and the
vesting schedule pursuant to which such shares may be purchased. You further
agree that any disclosure made by you in violation of this paragraph may, at the
Company's option, result in your forfeiture of this Award.

<Page>

     IN WITNESS WHEREOF, the Company has caused these presents to be executed as
of DATE.

                                        PICIS, INC.

                                        By:
                                            ------------------------------------
                                            Todd Cozzens
                                            INSERT AUTO SIG

     The undersigned Participant hereby accepts the foregoing Stock Option and
agrees to the several terms and conditions of this Award Agreement and of the
Plan.

                                        ----------------------------------------
                                        [typed name]

<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART II

                     TERMS AND CONDITIONS OF AWARD AGREEMENT

                                    ARTICLE I
                              AWARD OF STOCK OPTION

     1.1. GRANT OF STOCK OPTION. The Company hereby grants to the Participant
named in the Notice of Grant attached hereto as Part I of this Award Agreement a
Stock Option giving the right to purchase all or any part of the aggregate
number of shares of Common Stock as set forth in the Notice of Grant, at the
exercise price per share set forth in the Notice of Grant, subject to the terms
and conditions of the PICIS, Inc. 2000 Stock Option Plan.

     1.2 TIME LIMITATIONS ON EXERCISE OF STOCK OPTION. Except as otherwise
provided in the Plan, and subject to Section 1.3., below, the Stock Option
granted pursuant to this Award Agreement is exercisable, in whole or in part,
from the vesting date to the expiration date as set forth in the Notice of
Grant. In all events, the Stock Option will become fully vested and immediately
exercisable if the Participant is employed by the Company or its affiliates, or
if the Participant is currently serving as a director on the Board, upon a
Change in Control.

     1.3 TERMINATION OF EMPLOYMENT. The Stock Option shall be exercisable upon
the termination of the Participant's employment relationship with the Company
and its affiliates or upon the Participant's ceasing to serve as a director on
the Board only in the manner and to the extent provided in Section 11 of the
Plan, as modified herein. This Stock Option, to the extent vested on termination
of employment or service as a director, shall remain exercisable for a period of
six (6) months after the Participant's death or Disability as defined in Section
11(b) of the Plan. In all other cases, the Stock Option, to the extent vested on
termination of employment or service as a director, shall be exercisable for
ninety (90) days following the termination of the Participant's employment or
service for any reason other than Cause. If a Participant's employment or
service is terminated for Cause, the Stock Option shall expire immediately. Any
unvested portion of this Stock Option shall expire immediately upon
Participant's termination of employment for any reason. In all events, and
notwithstanding anything herein contained to the contrary, this Stock Option
shall expire no later than the expiration date as indicated in the Notice of
Grant.

     1.4. METHOD OF EXERCISING STOCK OPTION. The Stock Option may be exercised
in whole or in part by delivery to the Company, at its offices in Wakefield, MA,
of (a) a written notice in the form attached hereto as EXHIBIT B identifying the
Stock Option and stating the number of shares with respect to which it is being
exercised, and (b) payment in full of the exercise price of the shares then
being acquired in the form permitted by Section 1.5 of this Award Agreement. The
written notice shall be signed by the Participant and shall be delivered to the
Company in

<Page>

person, by certified mail with return receipt requested, or by facsimile to be
immediately confirmed by certified mail with return receipt requested. The
Company shall have the right to delay the issue or delivery of any shares to be
delivered hereunder until (a) the completion of such registration or
qualification of such shares under federal, state or foreign law, ruling or
regulation as the Company shall deem to be necessary or advisable, (b) receipt
from the Participant of such documents and information as the Company may deem
necessary or appropriate in connection with such registration or qualification
or the issuance of shares hereunder, and (c) arrangements satisfactory to the
Company have been made with regard to any tax withholding obligations the
Company believes is required as a result of the exercise of the Stock Option.

     1.5. METHODS OF PAYMENT. Payment of the exercise price for the shares of
Common Stock which are being purchased pursuant to the exercise of the Stock
Option shall be made using any of the following means of payment, at the
election of the Participant:

            (1) wire transfer;

            (2) check;

            (3) a tender of shares of Common Stock, either directly or by
     attestation, which have been held by the Participant for more than six
     months and have not been used within the prior six-month period to exercise
     a Stock Option, valued at Fair Market Value on the date of exercise; or

            (4) any combination of the foregoing means of payment.

     1.6. PROHIBITIONS AGAINST TRANSFER. The Stock Option, and the rights and
privileges conferred hereby, may not be transferred, assigned, pledged or
hypothecated in any way (whether by operation of law or otherwise) by the
Participant, or be subject to execution, attachment or similar process, and
shall be exercisable only by the Participant, except as provided in Section
11(b) of the Plan.

     1.7. PARTICIPANT'S REPRESENTATIONS. In the event the shares have not been
registered under the Securities Act of 1933, as amended (the "Securities Act"),
at the time this Stock Option is exercised, the Participant shall, if required
by the Company, concurrently with the exercise of all or any portion of this
Stock Option, deliver to the Company his or her Investment Representation
Statement in form attached hereto as EXHIBIT B.

     1.8. LOCK-UP PERIOD. If so requested by the Company or any representative
of the underwriters (the "Managing Underwriter") in connection with any
registration of the offering of any securities of the Company under the
Securities Act, the Participant shall not sell or otherwise transfer any shares
or other securities of the Company during the 180-day period (or such other
period as may be requested in writing by the Managing Underwriter and agreed to
in writing by the Company) (the "Market Standoff Period") following the
effective date of a registration statement of the Company filed under the
Securities Act. Such restriction shall apply only to the first registration
statement of the Company to become effective under the Securities Act that

                                        2
<Page>

includes securities to be sold on behalf of the Company to the public in an
underwritten public offering under the Securities Act. The Company may impose
stop-transfer instructions with respect to securities subject to the foregoing
restrictions until the end of such Market Standoff Period.

                                   ARTICLE II
                                  MISCELLANEOUS

     2.1. PROVISIONS OF THE PLAN CONTROL. This Award Agreement shall be governed
by the provisions of the Plan, the terms and conditions of which are
incorporated herein by reference. In the event that the provisions of this Award
Agreement and the Plan conflict, the Plan shall control. The Plan empowers the
Committee to make interpretations, rules and regulations thereunder, and, in
general, provides that determinations of such Committee with respect to the Plan
shall be binding upon the Participant.

     2.2. TAXES. The Company may require payment or reimbursement of or may
withhold any tax that it believes is required as a result of the exercise of the
Stock Option, and the Company may defer making delivery with respect to shares
for which the Stock Option was exercised until arrangements satisfactory to the
Company have been made with respect to such withholding obligations.

     2.3. NOTICES. Any notice to be given to the Company under the terms of this
Award Agreement shall be given in writing to the Company in care of its
Secretary at 100 Quannapowitt Parkway, Suite 405, Wakefield MA 01880. Any notice
to be given to the Participant may be addressed to him at his address as it
appears on the payroll or other records of the Company or any affiliate thereof.
Any such notice shall be deemed to have been duly given if and when actually
received by the party to whom it is addressed, as evidenced by a written receipt
to that effect.

     2.4. GOVERNING LAW. This Award Agreement and all questions arising
hereunder or in connection herewith shall be determined in accordance with the
laws of the State of Delaware, without giving effect to the principles of
conflicts of laws.

                                        3

<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART I

                         NOTICE OF GRANT OF STOCK OPTION

     We are pleased to inform you that you have been granted a Stock Option to
purchase shares of Common Stock of PICIS, Inc., subject to the terms and
conditions of the PICIS, Inc. 2000 Stock Option Plan (the "Plan") and of this
Award Agreement. Unless otherwise defined herein, all terms used in this Award
Agreement shall have the same meanings as set forth in the Plan.

     Award Number:

     Date of Award:

     Exercise price per share:

     Total number of shares:

     Total exercise price:

     1. NONQUALIFIED STOCK OPTION. The Stock Option granted pursuant to this
Award is intended to be a nonqualified stock option and therefore, shall not
qualify as an incentive stock option pursuant to Section 422 of the Code.

     2. VESTING SCHEDULE. The Stock Option granted pursuant to this Award is
immediately vested.

     3. EXPIRATION DATE. In all events, and notwithstanding anything herein
contained to the contrary, this Stock Option shall expire no later than DATE
[FIVE YEARS FROM DATE OF AWARD]

     By your signature and the signature of the Company's representative below,
you and the Company agree that the Stock Option which has been awarded to you
under this Award Agreement is subject to the terms and conditions of the Plan
which is attached hereto as Exhibit A. As provided in the Plan, you hereby agree
to accept as binding any decision of the Committee with respect to the
interpretation of the Plan and this Award Agreement, or any other matters
associated therewith. You further agree to notify the Company as soon as
possible upon any change in your residential address.

<Page>

     IN WITNESS WHEREOF, the Company has caused these presents to be executed as
of DATE.

                                        PICIS, INC.

                                        By:
                                            ----------------------------------
                                            Todd Cozzens
                                            INSERT AUTO SIG

     The undersigned Participant hereby accepts the foregoing Stock Option and
agrees to the several terms and conditions of this Award Agreement and of the
Plan.

                                        ---------------------------------------
                                        [typed name]

<Page>

                                   PICIS, INC.
                             2000 STOCK OPTION PLAN
                                 AWARD AGREEMENT

                                     PART II

                     TERMS AND CONDITIONS OF AWARD AGREEMENT

                                    ARTICLE I
                              AWARD OF STOCK OPTION

     1.1. GRANT OF STOCK OPTION. The Company hereby grants to the Participant
named in the Notice of Grant attached hereto as Part I of this Award Agreement a
Stock Option giving the right to purchase all or any part of the aggregate
number of shares of Common Stock as set forth in the Notice of Grant, at the
exercise price per share set forth in the Notice of Grant, subject to the terms
and conditions of the PICIS, Inc. 2000 Stock Option Plan.

     1.2 TIME LIMITATIONS ON EXERCISE OF STOCK OPTION. Except as otherwise
provided in the Plan, the Stock Option granted pursuant to this Award Agreement
is exercisable, in whole or in part, from the vesting date to the expiration
date as set forth in the Notice of Grant.

     1.3. METHOD OF EXERCISING STOCK OPTION. The Stock Option may be exercised
in whole or in part by delivery to the Company, at its offices in Wakefield, MA,
of (a) a written notice in the form attached hereto as EXHIBIT B identifying the
Stock Option and stating the number of shares with respect to which it is being
exercised, and (b) payment in full of the exercise price of the shares then
being acquired in the form permitted by Section 1.4 of this Award Agreement. The
written notice shall be signed by the Participant and shall be delivered to the
Company in person, by certified mail with return receipt requested, or by
facsimile to be immediately confirmed by certified mail with return receipt
requested. The Company shall have the right to delay the issue or delivery of
any shares to be delivered hereunder until (a) the completion of such
registration or qualification of such shares under federal, state or foreign
law, ruling or regulation as the Company shall deem to be necessary or
advisable, (b) receipt from the Participant of such documents and information as
the Company may deem necessary or appropriate in connection with such
registration or qualification or the issuance of shares hereunder, and (c)
arrangements satisfactory to the Company have been made with regard to any tax
withholding obligations the Company believes is required as a result of the
exercise of the Stock Option.

     1.4. METHODS OF PAYMENT. Payment of the exercise price for the shares of
Common Stock which are being purchased pursuant to the exercise of the Stock
Option shall be made using any of the following means of payment, at the
election of the Participant:

            (1) wire transfer;

            (2) check;

<Page>

            (3) a tender of shares of Common Stock, either directly or by
     attestation, which have been held by the Participant for more than six
     months and have not been used within the prior six-month period to exercise
     a Stock Option, valued at Fair Market Value on the date of exercise; or

            (4) any combination of the foregoing means of payment.

     1.5. PROHIBITIONS AGAINST TRANSFER. The Stock Option, and the rights and
privileges conferred hereby, may not be transferred, assigned, pledged or
hypothecated in any way (whether by operation of law or otherwise) by the
Participant, or be subject to execution, attachment or similar process, and
shall be exercisable only by the Participant, except as provided in Section
11(b) of the Plan.

     1.6. PARTICIPANT'S REPRESENTATIONS. In the event the shares have not been
registered under the Securities Act of 1933, as amended (the "Securities Act"),
at the time this Stock Option is exercised, the Participant shall, if required
by the Company, concurrently with the exercise of all or any portion of this
Stock Option, deliver to the Company his or her Investment Representation
Statement in form attached hereto as EXHIBIT C.

     1.7. LOCK-UP PERIOD. If so requested by the Company or any representative
of the underwriters (the "Managing Underwriter") in connection with any
registration of the offering of any securities of the Company under the
Securities Act, the Participant shall not sell or otherwise transfer any shares
or other securities of the Company during the 180-day period (or such other
period as may be requested in writing by the Managing Underwriter and agreed to
in writing by the Company) (the "Market Standoff Period") following the
effective date of a registration statement of the Company filed under the
Securities Act. Such restriction shall apply only to the first registration
statement of the Company to become effective under the Securities Act that
includes securities to be sold on behalf of the Company to the public in an
underwritten public offering under the Securities Act. The Company may impose
stop-transfer instructions with respect to securities subject to the foregoing
restrictions until the end of such Market Standoff Period.

                                   ARTICLE II
                                  MISCELLANEOUS

     2.1. PROVISIONS OF THE PLAN CONTROL. This Award Agreement shall be governed
by the provisions of the Plan, the terms and conditions of which are
incorporated herein by reference. In the event that the provisions of this Award
Agreement and the Plan conflict, the Plan shall control. The Plan empowers the
Committee to make interpretations, rules and regulations thereunder, and, in
general, provides that determinations of such Committee with respect to the Plan
shall be binding upon the Participant.

     2.2. TAXES. The Company may require payment or reimbursement of or may
withhold any tax that it believes is required as a result of the exercise of the
Stock Option, and the Company may defer making delivery with respect to shares
for which the Stock Option was

                                        2
<Page>

exercised until arrangements satisfactory to the Company have been made with
respect to such withholding obligations.

     2.3. NOTICES. Any notice to be given to the Company under the terms of this
Award Agreement shall be given in writing to the Company in care of its
Secretary at 100 Quannapowitt Parkway, Suite 405, Wakefield MA 01880. Any notice
to be given to the Participant may be addressed to him at his address as it
appears on the records of the Company or any affiliate thereof. Any such notice
shall be deemed to have been duly given if and when actually received by the
party to whom it is addressed, as evidenced by a written receipt to that effect.

     2.4. GOVERNING LAW. This Award Agreement and all questions arising
hereunder or in connection herewith shall be determined in accordance with the
laws of the State of Delaware, without giving effect to the principles of
conflicts of laws.

                                        3

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