Document:

EXHIBIT 10.16

                       REVOLVING CREDIT AND LOAN AGREEMENT

                          DATED AS OF DECEMBER 21, 1999

         KOS PHARMACEUTICALS, INC., a Florida corporation (the "Borrower"), and
MICHAEL JAHARIS, an individual residing in South Norwalk, Connecticut (the
"Lender"), agree as follows: ARTICLE I

                                   DEFINITIONS

         SECTION 1.01. ACQUISITION TRANSACTION shall mean (i) a merger or
consolidation, or any similar transaction, of Borrower into or with another
corporation or other entity (other than into or with a Related Company), (ii) a
purchase or other acquisition (including by way of merger, consolidation, share
exchange or otherwise) of securities representing 20% or more of the voting
power of Borrower; (iii) the sale of all or substantially all of the assets of
the Borrower, or (iv) any substantially similar transaction.

         SECTION 1.02. ADVANCES shall mean the advances made under the Note and
pursuant to this Agreement.

         SECTION 1.03. AMENDED AND RESTATED PATENT SECURITY AGREEMENT shall mean
the Amended and Restated Patent, Trademark and License Security Agreement of
even date herewith granted by Borrower to Lender as collateral security for the
Note and the

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September Note.

         SECTION 1.04. AMENDED AND RESTATED SECURITY AGREEMENT shall mean the
Amended and Restated Security Agreement of even date herewith granted by
Borrower to Lender as collateral security for the Note and the September Note.

         SECTION 1.05. AMENDED AND RESTATED STOCK PLEDGE AGREEMENT shall mean
the Amended and Restated Stock Pledge Agreement of even date herewith granted by
the Borrower to Lender as collateral security for the Note and the September
Note.

         SECTION 1.06. AMENDED AND RESTATED SUBSIDIARY GUARANTY shall mean the
Amended and Restated Guaranty of even date herewith granted by ATI to Lender
guaranteeing repayment of the Note and the September Note.

         SECTION 1.07. AMENDED AND RESTATED SUBSIDIARY SECURITY AGREEMENT shall
mean the Amended and Restated Subsidiary Security Agreement of even date
herewith granted by ATI to Lender as collateral security for the Amended and
Restated Subsidiary Guaranty.

         SECTION 1.08. ATI shall mean Aeropharm Technology, Inc., a Delaware
corporation which is a wholly owned subsidiary of Borrower.

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         SECTION 1.09. ATI STOCK PLEDGE AGREEMENT shall mean the Stock Pledge
Agreement of even date herewith granted by ATI to Lender as collateral security
for the Amended and Restated Subsidiary Guaranty.

         SECTION 1.10. BUSINESS DAY shall mean any day other than a Saturday,
Sunday or other day on which the Borrower's business is closed.

         SECTION 1.11. CLOSING DATE shall mean the date on which the closing for
this Loan is held.

         SECTION 1.12. COMMON STOCK shall mean the capital common stock of the
Borrower, consisting of 50,000,000 authorized shares $.01 par value.

         SECTION 1.13. COMPENSATION shall mean (i) any and all compensation,
including without limitation salaries, bonuses, commissions, fringe benefits,
deferred compensation, retirement benefit contributions and similar benefits,
paid to employees of the Borrower for services rendered, and (ii) any and all
compensation and payments, including without limitation payments reportable as
income to recipients on the various types of IRS Forms 1099, paid to recipients
for services rendered.

         SECTION 1.14. CREDIT FACILITY shall mean the $50,000,000.00

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revolving credit facility made available by the Lender pursuant to the Note.

         SECTION 1.15. DEBT shall mean the debt of any Person at any date,
without duplication in calculating the amount thereof, arising from:

                  (i) all obligations of such Person for borrowed money;

                  (ii) all obligations of such Person evidenced by bonds (other
         than performance bonds), debentures, notes or other similar
         instruments;

                  (iii) all trade credit and other obligations of such Person to
         pay the deferred purchase price of property or services;

                  (iv) all obligations of such Person as lessee under capital
         leases;

                  (v) all debt of others secured by a lien on any asset of such
         Person, whether or not such debt is assumed by such Person; and

                  (vi) all debt of others guaranteed by such Person.

         SECTION 1.16. ENVIRONMENTAL COMPLAINT shall mean any complaint, order,
citation or notice of violation of Environmental Laws with regard to air
emissions, water discharges, surface

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contamination, noise emissions or any other environmental, health or safety
matter affecting the Borrower or any of its real properties.

         SECTION 1.17. ENVIRONMENTAL LAWS means and includes the comprehensive
Environmental Response, Conservation and Liability Act of 1980, as amended, the
Resource Conservation and Recovery Act, the Superfund Amendments and
Reauthorization Act of 1986, as amended, the Toxic Substances Control Act, as
amended, the Clean Air Act, as amended, the Clean Water Act, as amended, any
other "Superfund" or "Superlien" law, or any other federal, state or local
statute, law, ordinance, code, rule, regulation, order or decree regulating,
relating to, or imposing liability or standards of conduct concerning any
Hazardous Materials, as now or at any time hereafter in effect.

         SECTION 1.18. ENVIRONMENTAL AND SAFETY REQUIREMENTS shall mean any and
all Environmental Laws and any other federal, state and local laws relating to
public health and safety, worker health and safety, and pollution or protection
of the environment, including, without limitation, laws relating to emissions,
discharges, releases or threatened releases of toxic or otherwise hazardous
materials, substances, or wastes into ambient air,

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surface water, groundwater, subsurface soil or lands or otherwise relating to
generation, the manufacture, processing, distribution, use, treatment, storage,
disposal, transport, or handling of toxic or otherwise hazardous materials,
substances or wastes.

         SECTION 1.19. EVENT OF DEFAULT shall mean an Event of Default under
Section 6.01.

         SECTION 1.20. EXCHANGE ACT shall mean the Securities Exchange Act of
1934, as amended from time to time.

         SECTION 1.21. HAZARDOUS DISCHARGE shall mean the happening of any event
involving the generation, use, spill, discharge or storage, disposal or cleanup
of any Hazardous Materials not in compliance with Environmental Laws.

         SECTION 1.22. HAZARDOUS MATERIAL shall mean any pollutant, contaminant,
toxic substance, hazardous waste, hazardous material, hazardous substance,
petroleum or petroleum product, asbestos, polychlorinated biphenyls, underground
storage tanks and the contents thereof including, without limitation, any such
materials defined in or regulated pursuant to the Resource Conservation and
Recovery Act, as amended, the Comprehensive Environmental Response, Conservation
and Liability Act, as amended, the Federal Clean Water Act as amended, the Toxic
Substances Control Act, as

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amended, the Hazardous Materials Transportation Act, as amended, or any other
Environmental Law, whether existing as of the date hereof, previously enforced,
or subsequently enacted.

         SECTION 1.23. IEP shall mean IEP Pharmaceutical Devices, Inc., a
Florida corporation which is a wholly owned subsidiary of Borrower.

         SECTION 1.24. IEP GUARANTY shall mean the Guaranty of even date
herewith granted by IEP to Lender guaranteeing repayment of the Note and the
September Note.

         SECTION 1.25. IEP SECURITY AGREEMENT shall mean the IEP Security
Agreement of even date herewith granted by IEP to Lender as collateral security
for the IEP Guaranty.

         SECTION 1.26. JULY CREDIT FACILITY shall mean the $30,000,000 revolving
credit facility made available by the Lender to the Borrower pursuant to that
certain Promissory Note by Borrower in favor of Lender dated as of July 1, 1998
and that certain Revolving Credit Facility and Loan Agreement between Borrower
and Lender dated as of July 1, 1998.

         SECTION 1.27. LOAN shall mean the loan made pursuant to Section 2.01
and the Note.

         SECTION 1.28. LOAN DOCUMENTS shall mean this Agreement, the

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Note, the Second Amended and Restated Registration Rights Agreement, the Amended
and Restated Security Agreement, the Amended and Restated Patent Security
Agreement, the Amended and Restated Stock Pledge Agreement, the Amended and
Restated Subsidiary Guaranty, the Amended and Restated Subsidiary Security
Agreement, the IEP Guaranty, the IEP Security Agreement, the UCC-1 financing
statements executed in connection with the security agreements, the Warrant
Agreement, and each and every other document executed or delivered in connection
with the closing of this transaction, each such document being referred to
individually as a "Loan Document".

         SECTION 1.29. MATURITY DATE shall mean June 30, 2005.

         SECTION 1.30. NOTE shall mean the promissory note referred to in
Section 2.01, substantially in the form of EXHIBIT I attached hereto and made a
part hereof.

         SECTION 1.31. PERMISSIBLE EQUIPMENT FINANCING INDEBTEDNESS shall mean
Debt incurred for equipment financing in the ordinary course of business (i) in
an amount not in excess of $250,000.00 in the aggregate for any one transaction,
or (ii) for the lease or purchase of automobiles for use by employees. For the
purpose of defining a transaction, all equipment orders from the same vendor

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or affiliated vendors made within a 30 day period for a group of similar or
interrelated items shall constitute one transaction.

         SECTION 1.32. PERMISSIBLE LETTER OF CREDIT INDEBTEDNESS shall mean Debt
incurred for the procurement of letters of credit (standby or documentary) in
the ordinary course of business in an amount not in excess of $2,000,000 in the
aggregate for all transactions at any one time. For the purpose of defining a
transaction, all letters of credit procured for the same underlying transaction
or a substantially related transaction shall constitute one transaction.

         SECTION 1.33. PERSON means any individual, joint venture, corporation,
company, limited liability company, voluntary association, partnership, limited
partnership, limited liability partnership, trust, joint stock company,
unincorporated organization, association, government, or any agency,
instrumentality, or political subdivision thereof, or any other form of entity.

         SECTION 1.34. RELATED COMPANY or RELATED COMPANIES shall mean (i) any
direct or indirect subsidiary of Borrower; (ii) Kos Investments, Inc., a
Delaware corporation, and all successors thereto; (iii) Kos Holdings, Inc., a
Delaware corporation, and all

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successors thereto.

         SECTION 1.35. RELATED PERSON or RELATED PERSONS shall mean any
stockholder of Kos Investments, Inc., a Delaware corporation, existing as of the
date of this Agreement.

         SECTION 1.36. REQUEST NOTICE shall mean a notice requesting an Advance
pursuant to Section 2.02 below, which notice shall be in the form and substance
attached hereto as EXHIBIT II hereto.

         SECTION 1.37. SECOND AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT
shall mean the Second Amended and Restated Registration Rights Agreement of even
date herewith entered into by Borrower in favor of Lender with respect to the
Common Stock to be issued upon exercise of warrants issued to Lender pursuant to
the Warrant Agreement or upon conversion of the September Note pursuant to
Article IV of the September Credit Agreement.

         SECTION 1.38. SECURITIES ACT shall mean the Securities Act of 1933, as
amended from time to time.

         SECTION 1.39. SEPTEMBER CREDIT AGREEMENT shall mean that certain
Revolving Credit and Loan Agreement between Borrower and Lender dated as of
September 1, 1999.

         SECTION 1.40. SEPTEMBER CREDIT FACILITY shall mean the $50,000,000
revolving credit facility made available by the Lender

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pursuant to the September Note and the September Credit Agreement.

         SECTION 1.41. SEPTEMBER NOTE shall mean that certain Promissory Note by
Borrower in favor of Lender dated as of September 1, 1999 in the principal
amount of $50,000,000.

         SECTION 1.42. SUBSIDIARIES shall mean ATI and IEP.

         SECTION 1.43. TAKE-OVER ATTEMPT shall mean any of the following
occurrences:

         (a) Any person (other than a Related Company or a Related Person) shall
have acquired beneficial ownership or the right to acquire beneficial ownership
of securities representing 20% or more of the aggregate voting power of Borrower
or any Related Company (the term "beneficial ownership" for purposes of this
Agreement having the meaning assigned thereto in Section 13(d) of the Exchange
Act, and the rules and regulations thereunder); or

         (b) Any person shall have engaged in an Acquisition Transaction.

         SECTION 1.44. TERMINATION DATE shall mean June 30, 2002.

         SECTION 1.45. WARRANT shall mean that certain warrant to purchase 6
million shares of Common Stock at a price of $5.00 per share.

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                                   ARTICLE II

                                    THE LOAN

         SECTION 2.01. THE LOAN. The Lender agrees, on the terms and conditions
hereinafter set forth, to make a Loan to the Borrower in an amount not to exceed
Fifty Million Dollars ($50,000,000.00) on the terms and conditions set forth
herein and in the Note.

         SECTION 2.02. MAKING ADVANCES. Upon the terms and subject to the
conditions herein set forth, the Lender shall from time to time make Advances to
the Borrower under the Loan up to an aggregate principal amount at any one time
outstanding not to exceed an amount equal to the Credit Facility. Any sums
advanced pursuant to this Section and subsequently repaid may be re-borrowed
from time to time, subject to the requirements of Section 2.02.

         (a) Borrower may use loan proceeds for any business purpose of
Borrower.

         (b) Nothing herein shall obligate the Lender to make any Advance in
excess of the maximum amount of the Credit Facility, the making of any or all
Advances in excess of the maximum amount

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of the Credit Facility to be in the sole and absolute discretion of the Lender.
If at any time an excess shall exist for any reason other than as specifically
authorized by Lender, the Borrower shall repay to the Lender forthwith, without
notice or demand, such amount as shall be necessary to eliminate such excess.

         (c) The Borrower shall give the Lender written or telegraphic notice of
its request for an Advance by submitting a Request Notice at least three (3)
Business Days prior to the requested date of the Advance. Each Request Notice
shall specify the date and the amount of the requested Advance. Each Advance
shall be in the minimum amount of $5,000.00 and in integral multiples of
$1,000.00. The Lender shall make each Advance in immediately available funds by
wire transfer to a deposit account designated by Borrower at its financial
institution, as soon as practicable, but in no event later than 3 business days
following the receipt by Lender of a Request Notice.

         (d) The Lender shall not be obligated to make Advances aggregating in
excess of $12,000,000 during any fiscal quarter of Borrower.

         SECTION 2.03. TERMINATION. Except as otherwise provided in

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this Agreement, the provisions of Section 2.02 relating to the making of
Advances under the Note shall remain in effect until the Termination Date, and
shall be terminated at such time unless otherwise renewed or extended by the
Lender. Notwithstanding any such termination, and subject to Lender's right to
exercise its rights and remedies under the Loan Documents upon the occurrence of
an Event of Default or otherwise, all of the provisions of this Loan Agreement
shall remain in effect while any part of the Loan remains outstanding, such
termination affecting only those provisions relating to the making of Advances.
All obligations of the Borrower in respect of the Note shall become due and
payable on the Maturity Date, without notice or demand.

         SECTION 2.04. EXCESS ADVANCES. Any Advances made at any time during the
term of the Loan by the Lender to the Borrower in excess of the face amount of
the Note shall, while outstanding, be deemed part of the indebtedness of
Borrower owed to the Lender under the Note and shall be equally subject to all
of the terms and provisions of this Agreement and the Loan Documents. Any
reference in any Loan Documents to the indebtedness or amounts owed under this
Agreement and the Note is hereby deemed to include such excess Advances.

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         SECTION 2.05. INCREASE IN LOAN AMOUNT. The amount of the Loan may be
increased from time to time by the execution and delivery of an amendment to
this Agreement setting forth the amount of such increase, duly executed by the
Lender and the Borrower, and the execution and delivery by the Borrower of a
note in substantially the form of EXHIBIT I attached hereto in the principal
amount of such increase. Upon execution and delivery of any such note, any
reference to the term "Loan Documents" herein or in any Loan Document shall be
deemed to include reference to such note.

         SECTION 2.06. PAYMENTS AND COMPUTATIONS. The Borrower shall make each
payment under any Loan Document not later than 3:00 p.m. (New York City time) on
the day when due in lawful money of the United States of America to the Lender
at its address referred to in Section 8.02 in immediately available funds. All
computations of interest under the Note shall be made by the Lender on the basis
of a 360-day year, for the actual number of days (including the first day but
excluding the last day) elapsed.

         SECTION 2.07. PAYMENT ON NON-BUSINESS DAYS. Whenever any payment to be
made hereunder or under the Note shall be stated to

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be due on a day which is not a Business Day, such payment may be made on the
next succeeding Business Day, and such extension of time shall in such case be
included in the computation of payment of interest.

         SECTION 2.08. TERMINATION OF FACILITY. The Lender's obligation to make
available to the Borrower the Credit Facility and to make Advances thereunder
shall terminate, at the Lender's option, upon the occurrence of any of the
following events:

                  (i) termination of the availability of the Credit Facility
         pursuant to Section 2.03; or

                  (ii) an Event of Default.

                                   ARTICLE III
                              CONDITIONS OF LENDING

         SECTION 3.01. CONDITIONS PRECEDENT TO CLOSING. The obligation of the
Lender to close the Loan and make any Advances hereunder at closing shall be
subject to the condition precedent that the Lender shall have received on or
before the Closing Date the following, each dated the Closing Date, in form and
substance satisfactory to the Lender:

         (a) The Note, duly executed by the Borrower;

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         (b) The Second Amended and Restated Registration Rights Agreement, duly
executed by the Borrower;

         (c) The Amended and Restated Security Agreement, duly executed by the
Borrower;

         (d) The Amended and Restated Patent Security Agreement, duly executed
by the Borrower;

         (e) The Amended and Restated Subsidiary Security Agreement, duly
executed by ATI;

         (f) The Amended and Restated Subsidiary Guaranty, duly executed by ATI;

         (g) The IEP Guaranty, duly executed by IEP;

         (h) The IEP Security Agreement, duly executed by IEP;

         (i) The ATI Stock Pledge Agreement, duly executed by ATI;

         (j) UCC-1 financing statements with respect to the security interests
granted to Lender by IEP under the Loan Documents for such locations as the
Lender may deem necessary to perfect the Lender's security interests, duly
executed by IEP;

         (k) The Warrant, duly executed by the Borrower.

         (l) The Amended and Restated Stock Pledge Agreement, duly executed by
the Borrower;

         (m) A conditional assignment of Borrower's lease(s) of real

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property, together with a written consent to such assignment from Borrower's
landlord(s) and a written waiver by such landlord(s) of certain rights of
landlord under its lease(s) in furtherance of the exercise by Lender of its
rights under the Amended and Restated Security Agreement, all in form and
substance satisfactory to Lender;

         (n) A binder of an endorsement to Borrower's fire, hazard and extended
coverage insurance policy (with a long form endorsement) with respect to the
assets given as collateral pursuant to the Amended and Restated Security
Agreement showing the Lender as loss payee in form satisfactory to the Lender
and to Borrower's comprehensive liability policy (with a long form endorsement)
and Borrower's product liability policy (with a long form endorsement) with
respect to Borrower's business showing the Lender as an additional insured under
such policy;

         (o) A binder of an endorsement to business interruption coverage
insurance policy (with a long form endorsement) with respect to Borrower's
business showing the Lender as loss payee in form satisfactory to the Lender;

         (p) A certified copy of the resolutions of the board of directors of
the Borrower approving this transaction in the form

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attached as EXHIBIT III;

         (q) A certificate of the secretary or an assistant secretary of the
Borrower certifying the names and true signatures of the officers of the
Borrower authorized to sign each Loan Document to which it is a party and the
other documents to be delivered by it hereunder;

         (r) Copies of consents of third parties necessary for the consummation
of this transaction;

         (s) A favorable opinion of counsel for the Borrower, in substantially
the form of EXHIBIT IV and as to such other matters as the Lender may reasonably
request; and

         (t) Such other documents and information as the Lender may reasonably
request.

         SECTION 3.02. CONDITIONS PRECEDENT TO ADVANCES. The obligation of the
Lender to make any Advances under the Note is subject to the condition precedent
that the Lender shall have received at least three Business Days before the date
of such Advance, in form and substance satisfactory to the Lender:

         (a) A Request Notice, the representations and warranties contained
within which shall be true and accurate as of the date of the Advance being
requested;

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         (b) The representations and warranties contained in Section 5.0l below
shall be true and correct on and as of the date of such requested Advance as
though made on and as of such date;

         (c) As of the date of such requested Advance, no event shall have
occurred and be continuing, or would result from the Advance requested thereby,
which would constitute an Event of Default or would constitute an Event of
Default but for the requirement that notice be given or time elapse, or both;

         (d) As of the date of such requested Advance, there shall not have
occurred any material adverse change in the business or financial operations or
condition of the Borrower or in its management;

         (e) As of the date of such requested Advance, all loan proceeds
available under the September Credit Facility shall have been advanced to
Borrower and shall remain outstanding, except to the extent that any portion of
the outstanding balance under the September Credit Facility is converted
pursuant to the terms of the September Note and the September Credit Agreement.

         (f) As of the date of such requested Advance, there shall not be any
pending, or to the best of its knowledge, threatened action or proceeding
affecting the Borrower before any court,

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governmental agency or arbitrator which is likely to have a materially adverse
effect on the financial condition or operations of the Borrower;

         (g) The Borrower shall waive any claim or defense based upon the
occurrence of any action or inaction of Lender on or prior to the date of such
requested Advance which Borrower believes at such time may (i) be actionable
against Lender, or (ii) give rise to a defense to payment under the Loan
Agreement or the Note for any reason, including without limitation, commission
of a tort or violation of any contractual duty or duty implied at law;

         (h) As of the date of such requested Advance, the death of Lender shall
not have occurred;

         (i) The Lender, together with Lender's spouse and children and any
entity of which Lender owns a majority interest, shall continue to own directly
and indirectly at least forty percent (40%) of the outstanding shares of Common
Stock of the Borrower; and

         (j) Such approvals, opinions and documents as the Lender may reasonably
request.

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                                   ARTICLE IV
                         REPRESENTATIONS AND WARRANTIES

         SECTION 4.01. REPRESENTATIONS AND WARRANTIES OF THE BORROWER. Except as
otherwise disclosed in a schedule or schedules attached hereto and made a part
hereof, the Borrower represents and warrants as follows:

         (a) The Borrower is a corporation duly incorporated, validly existing
and its status is active under the laws of the State of Florida, has the
requisite power and authority to own its properties and assets and to carry on
its business as now conducted, and is duly qualified to do business as a foreign
corporation and is in good standing in each jurisdiction in which failure to so
qualify would have a material adverse effect on the transaction contemplated
hereby.

         (b) The authorized capital stock of the Borrower consists exclusively
of (A) 50,000,000 shares of Common Stock, par value $.01 per share, of which
18,020,752 shares are issued and outstanding as of December 20, 1999, and (B)
10,000,000 shares of preferred stock, par value $.01 per share, of which no
shares are issued and outstanding. All issued and outstanding shares of the

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capital stock of the Borrower and of each of its subsidiaries have been fully
paid, were duly authorized and validly issued, are nonasesssable and have been
issued pursuant to an effective registration statement under the Securities Act
or an appropriate exemption from registration under the Securities Act and were
not issued in violation of the preemptive rights of any shareholder.

         (c) The execution, delivery and performance by the Borrower of this
Agreement, the Note and each other Loan Document to which the Borrower is a
party have been duly authorized by all necessary corporate action and do not and
will not:

                  (i) require any consent or approval of the share-holders of
         the Borrower not already obtained;

                  (ii) contravene the Borrower's governing documents;

                  (iii) violate any provision of any law, rule, regulation
         (including, without limitation, Regulation X of the Board of Governors
         of the Federal Reserve System), order, writ, judgment, injunction,
         decree, determination or award presently in effect having applicability
         to the Borrower;

                  (iv) result in a breach of or constitute a default under any
         indenture or loan or credit agreement or any other agreement, lease or
         instrument to which the Borrower is a

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         party or by which it or its properties may be bound or affected; or

                  (v) result in, or require, the creation or imposition of any
         mortgage, deed of trust, pledge, lien, security interest or other
         charge or encumbrance of any nature (other than arising under a Loan
         Document) upon or with respect to any of the properties now owned or
         hereafter acquired by the Borrower;

and the Borrower is not in default under any such law, rule, regulation, order,
writ, judgment, injunction, decree, determination or award or any such
indenture, agreement, lease or instrument.

         (d) No authorization or approval or other action by, and no notice to
or filing with, any governmental authority or regulatory body is required for
the due execution, delivery and performance by the Borrower of any Loan Document
to which it is or will be a party.

         (e) This Agreement is, and each other Loan Document to which the
Borrower will be a party when delivered hereunder will be, legal, valid and
binding obligations of the Borrower enforceable against the Borrower in
accordance with their respective terms,

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and there has not occurred any action or inaction of Lender which Borrower
believes may (i) be actionable against Lender, or (ii) give rise to a defense,
to payment hereunder or under the Note for any reason, including without
limitation, commission of a tort or violation of any contractual duty or duty
implied at law.

         (f) The consolidated balance sheet of the Borrower as of December 31,
1998, and the related consolidated statements of operations, shareholders'
equity and cash flows for the fiscal year then ended, audited by Arthur
Andersen, LLP, and the consolidated balance sheet of the Borrower as of
September 30, 1999, and the related consolidated statements of operations,
shareholders' equity and cash flows for the quarter then ended, copies of which
have been furnished to the Lender, fairly present the financial condition of the
Borrower as at such date and its results of operations for the year then ended
in accordance with generally accepted accounting principles, consistently
applied, and since December 31, 1998 and September 30, 1999, there has been no
material adverse change in such condition or operations.

         (g) There is no pending, or to the best of its knowledge, threatened
action or proceeding affecting the Borrower before any court, governmental
agency or arbitrator which may materially

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adversely affect the financial condition or operations of the Borrower.

         (h) The Borrower is not engaged in the business of extending credit for
the purpose of purchasing or carrying margin stock (within the meaning of
Regulation U issued by the Board of Governors of the Federal Reserve System),
and no proceeds of the Loan will be used to purchase or carry any margin stock
or to extend credit to others for the purpose of purchasing or carrying any
margin stock.

         (i) There are no recorded and/or perfected mortgages, deeds of trust,
liens, security interests or, to the best of its knowledge, other charges and
encumbrances (including liens or the retained titles of conditional vendors) of
any nature whatsoever on any properties of the Borrower other than those
permitted under Section 5.02(a) hereof.

         (j) The Borrower has filed all tax returns (federal, state and local)
required to be filed and has paid all taxes shown thereon to be due, including
interest and penalties, or provided adequate reserves for payment thereof.

         (k)  ENVIRONMENTAL MATTERS.

                  (i) The Borrower has obtained all material permits,

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         licenses and other authorizations required under Environmental and
         Safety Requirements, except for any licenses, permits or authorizations
         the failure to obtain which would not reasonably be expected to have a
         material adverse effect on the operations or financial condition of the
         Company.

                  (ii) The Borrower is in material compliance with all material
         terms and conditions of any required material permits, licenses, and
         authorizations and with all other material limitations, restrictions,
         conditions, standards, prohibitions, requirements, obligations,
         schedules and timetables contained in any Environmental and Safety
         Requirements or any notice or demand letters issued, entered,
         promulgated or approved thereunder, except where the failure to so
         comply would not reasonably be expected to have a material adverse
         effect on the operations or financial condition of Borrower.

                  (iii) The Borrower has not received any material written
         notice, demand, complaint, or order from any governmental authority or
         private party relating to material environmental impairments or
         liabilities with respect to the

                                       27
<PAGE>

         operation of its businesses or any of its real properties or advising
         the Borrower that it is potentially responsible for material response
         costs or remediation with respect to a release or threatened release of
         Hazardous Materials, any of which, if adversely resolved, would
         reasonably be expected to have a material adverse effect on the
         operations or financial condition of the Borrower.

                  (iv) None of the real property owned or leased by the Borrower
         is subject to a private or governmental lien arising under
         Environmental Laws.

         (l) No information, exhibit or report furnished by the Borrower to the
Lender in connection with the negotiation of this Agreement or any other Loan
Document or any representations and warranties herein contains or contained any
material misstatement of fact or omitted to state a material fact necessary to
make the statements contained therein not misleading. Borrower acknowledges that
the Lender is relying upon these representations and warranties in making the
loan contemplated herein.

                                    ARTICLE V
                            COVENANTS OF THE BORROWER

                                       28
<PAGE>

         SECTION 5.01. AFFIRMATIVE COVENANTS. So long as the Note shall remain
unpaid, the Borrower will, unless the Lender shall otherwise consent in writing:

         (a) COMPLIANCE WITH LAWS, ETC. Comply in all material respects with all
applicable laws, rules, regulations and orders, such compliance to include,
without limitation, paying before the same become delinquent all taxes,
assessments and governmental charges imposed upon it or upon its property except
to the extent contested in good faith.

         (b) MAINTENANCE OF INSURANCE. Maintain insurance with responsible and
reputable insurance companies or associations in such amounts and covering such
risks as is usually carried by companies engaged in similar businesses and
owning similar properties in the same general areas in which the Borrower
operates.

         (c) MAINTENANCE OF PROPERTIES, ETC. Maintain and preserve all of its
properties, necessary or useful in the proper conduct of its business, in good
working order and condition, ordinary wear and tear excepted.

         (d) KEEPING OF RECORDS AND BOOKS OF ACCOUNT. Keep adequate

                                       29
<PAGE>

records and books of account, in which complete entries will be made in
accordance with generally accepted accounting principles consistently applied,
reflecting all financial transactions of the Borrower.

         (e) PRESERVATION OF CORPORATE EXISTENCE, ETC. Preserve and maintain its
corporate existence, rights, franchises and privileges in the jurisdiction of
its incorporation, and qualify and remain qualified as a foreign corporation in
each jurisdiction in which such qualification is necessary in view of its
business and operations or the ownership of its properties and in which the
failure to qualify would have a material adverse effect on Borrower's business
or prospects.

         (f) ACCESS TO RECORDS. At any reasonable time and from time to time,
upon at least three days' oral or written notice (unless the Borrower is in
default, in which case no notice shall be necessary), permit the Lender or any
agents or representatives thereof during normal business hours to examine and at
Borrower's expense make copies of and abstracts from the records and books of
account of, and to visit the properties of, the Borrower and to discuss the
affairs, finances and accounts of the Borrower with any of its officers or
directors; provided, however, that prior to

                                       30
<PAGE>

the occurrence of an Event of Default no such actions by the Lender shall be
taken in a manner that would disrupt Borrower in the conduct of its business.
Until such time as Lender enforces its rights and exercises it remedies upon or
after an Event of Default, Lender shall keep confidential any information which
it obtains in the course of such examination and investigation and shall not
disclose such information to anyone other than agents, representatives and
advisors of Lender, except that this obligation to keep information confidential
shall not apply to information that (i) is already in Lender's possession,
provided that such information is not known by Lender to be subject to another
confidentiality agreement with or other obligation of secrecy to the Borrower or
another party, (ii) becomes generally available to the public other than as a
result of a disclosure by Lender or Lender's agents, representatives or advisors
or (iii) becomes available to Lender on a nonconfidential basis from a source
other than the Borrower or its advisors, provided that such source is not known
by Lender to be bound by a confidentiality agreement with or other obligation of
secrecy to the Borrower or another party.

         (g) REPORTING REQUIREMENTS. Furnish to the Lender:

                                       31
<PAGE>

                  (i) as soon as available and in any event within forty-five
         (45) days after the end of each quarter of each fiscal year of the
         Borrower other than the fourth quarter, a consolidated balance sheet of
         the Borrower as of the end of such quarter and the related consolidated
         statements of operations and cash flows for the period commencing at
         the end of the previous fiscal year and ending with the end of such
         quarter, certified as to fairness of presentation, generally accepted
         accounting principles and consistency by the chief accounting officer
         of the Borrower, together with a certificate of such chief accounting
         officer stating that as of the date of such certificate there is no
         continuing Event of Default or event which, with notice or lapse of
         time or both, would constitute an Event of Default, or, if an Event of
         Default or such an event has occurred and is continuing, a statement as
         to the nature thereof and the action which the Borrower has taken or
         proposes to take with respect thereto;

                  (ii) as soon as available and in any event within ninety (90)
         days after the end of each fiscal year of the Borrower, a consolidated
         balance sheet of the Borrower as of the end of such fiscal year and the
         related consolidated

                                       32
<PAGE>

         statements of operations, shareholders' equity and cash flows for such
         fiscal year, certified without material qualification by the Company's
         independent public accountants acceptable to the Lender, which shall be
         one of the six largest national public accounting firms;

                  (iii) as soon as possible and in any event within five (5)
         days after the Borrower has knowledge of the occurrence of each Event
         of Default, continuing on the date of such statement, the statement of
         the chief accounting officer of the Borrower setting forth details of
         such Event of Default or event and the action which the Borrower has
         taken or proposes to take with respect thereto;

                  (iv) as soon as available, and in any event within five (5)
         days thereafter, notification of any proposed or pending change of
         executive officers of the Borrower (as defined in the rules and
         regulations of the Securities and Exchange Commission);

                  (v) promptly after the commencement thereof, notice of all
         actions, suits and proceedings before any court or governmental
         department, commission, board, bureau, agency or instrumentality,
         domestic or foreign, affecting the Borrower

                                       33
<PAGE>

         of the type described in Section 4.01(g) hereof;

                  (vi) promptly after the furnishing thereof, copies of any
         statement or report furnished to any financial institution or other
         lender pursuant to the terms of any loan or credit or similar agreement
         and not otherwise required to be furnished to the Lender pursuant to
         any other clause of this subsection (g);

                  (vii) as soon as available, and in any event within five (5)
         days thereafter, notification of (X) any bona fide proposal to Borrower
         or its shareholders, by public announcement or written communication
         that is or becomes the subject of public disclosure, to engage in an
         Acquisition Transaction, or (B) the commencement (as such term is
         defined in Rule 14d-2 under the Exchange Act) of, or the filing of a
         registration statement under the Securities Act with respect to, a
         tender offer or exchange offer to purchase any shares of Common Stock
         such that, upon consummation of such offer, such person would own or
         control securities representing 10% or more of the aggregate voting
         power of Borrower or any Related Company; and

                  (viii) such other information respecting the condition

                                       34
<PAGE>

         or operations, financial or otherwise, of the Borrower as the Lender
         may from time to time reasonably request.

         SECTION 5.02. NEGATIVE COVENANTS. So long as the Note shall remain
unpaid, the Borrower will not, without the written consent of the Lender:

         (a) LIENS, ETC. Create or suffer to exist any lien, security interest
or other charge or encumbrance, or any other type of preferential arrangement,
upon or with respect to any of its properties, whether now owned or hereafter
acquired, or assign any right to receive income, in each case to secure any Debt
of any Person, except that the foregoing restrictions shall not apply to
mortgages, deeds of trust, pledges, liens, security interests or other charges
or encumbrances:

                  (i) existing as of the date hereof and listed in SCHEDULE A
         attached hereto and made a part hereof;

                  (ii) for taxes, assessments or governmental charges or levies
         on property of the Borrower if the same shall not at the time be
         delinquent or thereafter can be paid without penalty, or are being
         contested in good faith and by appropriate proceedings;

                  (iii) imposed by law, such as carriers, landlord's,

                                       35
<PAGE>

         warehousemen's and mechanics' liens and other similar liens arising in
         the ordinary course of business;

                  (iv) arising out of pledges or deposits under workmen's
         compensation laws, unemployment insurance, old age pensions, or other
         social security or retirement benefits, or similar legislation; or

                  (v) securing Permissible Equipment Financing Indebtedness or
         Permissible Letter of Credit Indebtedness.

         (b) DEBT. Create or suffer to exist any Debt, except:

                  (i) Debt existing as of the date hereof and listed in SCHEDULE
         A attached hereto;

                  (ii) Debt under the Loan Documents;

                  (iii) Permissible Equipment Financing Indebtedness

                  (iv) Permissible Letter of Credit Indebtedness, including
         without limitation the $3,000,000 Letter of Credit Agreement dated July
         17, 1999 with First Union National Bank; provided that the indebtedness
         thereunder shall at no time exceed the $2,000,000 limitation set forth
         in Section 1.32 above; and

                  (v) Debt authorized under subsection 5.02(c).

         (c) ASSUMPTIONS, GUARANTIES, ETC. OF INDEBTEDNESS OF OTHER

                                       36
<PAGE>

PERSONS. Assume, guarantee, endorse or otherwise become directly or contingently
liable (including, without limitation, liable by way of agreement, contingent or
otherwise, to purchase, to provide funds for payment, to supply funds to or
otherwise invest in the debtor or otherwise to assure the creditor against loss)
in connection with any Debt or indebtedness, except guaranties by endorsement of
negotiable instruments for deposit or collection or similar transactions in the
ordinary course of business.

         (d) LOANS AND INVESTMENTS. Lend or advance money, credit or property to
any Person or invest (by capital contribution or otherwise) in any Person, or
purchase or repurchase of the stock or indebtedness or all or a substantial part
of the assets or properties of any Person, or agree to do any of the foregoing,
except for:

                  (i) direct obligations of, or obligations the principal of and
         interest on which are unconditionally guaranteed by, the United States
         of America and which mature within one year from the date of
         acquisition thereof;

                  (ii) investments in commercial paper of any corporation with a
         maturity not in excess of thirty days from the date of acquisition
         thereof and rated P-1 or better by Moody's

                                       37
<PAGE>

         Investors services Inc., or A-1 or better by Standard & Poor's
         Corporation;

                  (iii) investments in certificates of deposit with a maturity
         not in excess of ninety days from the date of acquisition thereof,
         issued by any commercial bank organized and existing under the laws of
         the United States of America or under any state of the United States of
         America and having a combined capital and undivided surplus of not less
         than $100,000,000, provided, however, that certificates of deposit at
         any one bank shall at no time exceed ten percent (10%) of the undivided
         capital and surplus of such bank;

                  (iv) accounts receivable owing to the Borrower, if created or
         acquired in the ordinary course of business in connection with the sale
         by the Borrower of inventory and payable or dischargeable in accordance
         with customary trade terms; commission advances and other advances to
         officers and employees for travel and other business-related expenses,
         each in the ordinary course of business; and

                  (v) Loans and advances in each instance in an amount of not
         more than $10,000 and in the aggregate with respect to such loans and
         advances in an amount of not more than

                                       38
<PAGE>

         $100,000.

         (e) MERGERS, ETC. Merge or consolidate with any Person in a transaction
after which the holders of voting shares of Borrower (or of any class of voting
shares of Borrower) immediately prior to such transaction fail to own at least a
majority of the voting shares of the surviving entity (or of the shares of such
class of voting shares of the surviving entity) following such transaction.

         (f) SALES, ETC. OF ASSETS. Sell, assign, lease or otherwise dispose of
(whether in one transaction or in a series of transactions) substantially all of
its assets (whether now owned or hereafter acquired), or of substantially all of
the assets of any direct or indirect subsidiary of Borrower, to an unaffiliated
Person.

         (g) CHANGE IN BOARD CONTROL. Enter into a transaction after which the
members of the board of directors of Borrower immediately prior to such
transaction fail to constitute at least a majority of the board of directors of
the surviving entity following such transaction.

         (h) CHANGE IN NATURE OF BUSINESS. Make any material change in the
nature of the business of the Borrower, taken as a whole, as carried on at the
date hereof.

                                       39
<PAGE>

         (i) PURCHASE OF SECURITIES. Purchase, acquire, redeem or retire, or
make any commitment to purchase, acquire, redeem or retire, any of its capital
stock, whether now or hereafter outstanding.

         (j) ISSUANCE OF SECURITIES. Issue any stock or other securities in
addition to, in substitution for or in respect of its currently outstanding
capital stock, or raise capital or funds from the capital markets in
consideration for the present or future issuance of any form of securities of
the Borrower.

         (k) PROHIBITED TRANSFERS. Transfer, in any manner, either directly or
indirectly, any cash, property, or other assets to any parent or any of its
affiliates or subsidiaries, other than sales made in the ordinary course of
business and for fair consideration on terms no less favorable than if such sale
had been an arms-length transaction between the Borrower and an unaffiliated
entity.

         (l) CHARTER AMENDMENTS. Amend its articles or certificate of
incorporation without the prior written consent of Lender.

         SECTION 5.03. FINANCIAL COVENANTS. So long as the Note shall remain
unpaid, the Borrower will not fail, without the prior

                                       40
<PAGE>

written consent of the Lender, to comply with the financial covenants set forth
in SCHEDULE B.

                                   ARTICLE VI
                                EVENTS OF DEFAULT

         SECTION 6.01. EVENTS OF DEFAULT. The occurrence of any of the following
events shall constitute an Event of Default hereunder:

         (a) The Borrower shall, unless the Lender otherwise consents in
writing, fail to pay any installment of principal of, or interest on, the Note
within ten (10) days after such payment is due; or

         (b) Any representation or warranty made by the Borrower (or any of its
officers) under or in connection with any Loan Document or any other document
delivered in connection therewith shall prove to have been incorrect in any
material respect when made; or

         (c) The Borrower shall fail to perform or observe any other term,
covenant or agreement contained in any Loan Document, or in any other document
delivered in connection therewith, on its part to be performed or observed and,
in the case of a term, covenant or agreement other than one requiring payment of
funds to Lender,

                                       41
<PAGE>

any such failure shall remain unremedied for thirty (30) days after written
notice thereof shall have been given to such Borrower by the Lender; provided,
however, that if by the end of such thirty day period the Borrower has
substantially cured the applicable failure, and such failure has not caused, and
is not expected to immediately cause, a material adverse effect on the Borrower
or its subsidiaries, the Borrower shall have an additional thirty (30) days to
remedy the failure; or

         (d) The Borrower shall:

                  (i) fail to pay any Debt of such Borrower to the Lender
         (excluding Debt evidenced by the Note), or any interest or premium
         thereon, when due (whether by scheduled maturity, required prepayment,
         acceleration, demand or otherwise) and such failure shall continue
         after the applicable grace period, if any, specified in the agreement
         or instrument relating to such Debt, or

                  (ii) fail to pay any other Debt in excess of $250,000.00
         (excluding Debt owed to the Lender) of such Borrower, or any interest
         or premium thereon, when due (whether by scheduled maturity, required
         prepayment, acceleration, demand or otherwise) and such failure shall

                                       42
<PAGE>

         continue after the applicable grace period, if any, specified in the
         agreement or instrument relating to such Debt, or

                  (iii) fail to perform or observe any term, covenant or
         condition on its part to be performed or observed under any agreement
         or instrument relating to any Debt, when required to be performed or
         observed, and such failure shall continue after the applicable grace
         period, if any, specified in such agreement or instrument, if the
         effect of such failure to perform or observe is to accelerate (or, in
         the case of Debt owed to Lender, is to entitle Lender to accelerate)
         the maturity of such Debt; or any such Debt shall be declared to be due
         and payable, or required to be prepaid (other than by a regularly
         scheduled required prepayment) prior to the stated maturity thereof; or

         (e) The Borrower shall admit in writing its inability to pay its debts,
or shall make a general assignment for the benefit of creditors; or any
proceeding shall be instituted by or against the Borrower seeking to adjudicate
it a bankrupt or insolvent, or seeking reorganization, arrangement, adjustment,
or composition of it or its debts under any law relating to bankruptcy,
insolvency or reorganization or relief of debtors, or seeking appointment of

                                       43
<PAGE>

a receiver, trustee, or other similar official for it or for any substantial
part of its property, which proceeding is not dismissed within thirty (30) days
after being instituted; or the Borrower shall take any corporate action to
authorize any of the actions set forth above in this subsection (e); or

         (f) A non-appealable final judgment or order for the payment of money
shall be rendered against the Borrower to the extent to which such judgment or
order exceeds $250,000.00 (or, in the case of insurance coverage for such
payment, exceeds such insurance payment by $250,000.00); or

         (g) Any provision of any Loan Document after delivery thereof shall for
any reason cease to be valid and binding on the Borrower which is a party
thereto, or the Borrower shall so state in writing; or

         (h) Any material adverse change in the financial condition or business
operations of the Borrower shall occur and be continuing; provided, however,
that in no event shall the lack of Borrower's working capital constitute such a
material adverse change; or

         (i) The dissolution or liquidation of the Borrower; or

         (j) The occurrence of an Acquisition Transaction; or

         (k) A Take-Over Attempt.

                                       44
<PAGE>

         SECTION 6.02. REMEDIES UPON DEFAULT. Upon the occurrence of an Event of
Default, the Lender may, at its option, either separately or cumulatively:

         (a) declare the Note, all interest thereon and all other amounts
payable under this Agreement to be forthwith due and payable, whereupon the
Note, all such interest and all such amounts shall become and be forthwith due
and payable, without presentment, demand, protest or further notice of any kind,
all of which are hereby expressly waived by the Borrower;

         (b) exercise any or all of its rights or remedies permitted by
applicable law of a secured party under the Amended and Restated Security
Agreement or the Amended and Restated Patent Security Agreement;

         (c) if such Event of Default occurs prior to the Termination Date,
notify the Borrower in writing of the termination of the making of Advances
under Section 2.02, upon which notification the Borrower shall no longer be
entitled to Advances under the Note; and

         (e) exercise any or all of its rights or remedies permitted by
applicable law in any capacity under the Loan Documents or applicable law.

                                       45
<PAGE>

                                   ARTICLE VII
              INDEMNIFICATION AND LIMITATION ON LIABILITY OF LENDER

         SECTION 7.01. COSTS, EXPENSES AND TAXES. The Borrower agrees to pay on
demand all costs and expenses in connection with the preparation, execution,
delivery, filing, and recording of the Loan Documents, and the other documents
to be delivered under the Loan Documents, including, without limitation, the
reasonable fees and out-of-pocket expenses of legal counsel for the Lender and
fees and out-of-pocket expenses of Lender's advisors with respect thereto, and
all costs and expenses, if any, including, without limitation, the reasonable
fees and out-of-pocket expenses of legal counsel for the Lender, in connection
with the enforcement of the Loan Documents and the other documents to be
delivered under the Loan Documents, the filing or recording of financing
statements and other documents (including all taxes in connection therewith) in
public offices, the payment or discharge of any taxes, insurance premiums or
encumbrances, or in defending or prosecuting any actions or proceedings arising
out of or related to this Agreement or any other Loan Document or any
obligations of

                                       46
<PAGE>

Borrower to the Lender and the amount of all claims in connection therewith. In
addition, the Borrower shall pay any and all documentary or similar taxes and
fees payable or determined to be payable in connection with the execution,
delivery, filing and recording of the Loan Documents and the other documents to
be delivered under the Loan Documents, in connection with the making of Advances
and in connection with the issuance of Common Stock pursuant to the exercise of
any Warrants and the registration of such stock under the securities laws, and
agrees to save the Lender harmless from and against any and all liabilities with
respect to or resulting from any delay in paying or omission to pay such taxes
and fees.

         SECTION 7.02. GENERAL INDEMNIFICATION. Except as otherwise provided in
the Second Amended and Restated Registration Rights Agreement, Borrower hereby
agrees to defend the Lender and its officers, directors, agents, employees, and
counsel from, and hold each of them harmless against, any and all losses,
liabilities, claims, damages, interests, judgments, costs and expenses incurred
by any of them, including without limitation reasonable attorneys fees and
disbursements, arising out of or in connection with the making, administration,
or enforcement of the Loan or the

                                       47
<PAGE>

execution of this Agreement or any other Loan Document, other than as such may
be caused by Lender's or such other Person's willful misconduct. All obligations
provided for in this Section 8.02 shall survive any termination of this
Agreement and any other Loan Document.

         SECTION 7.03. ENVIRONMENTAL INDEMNIFICATION.

         (a) Borrower hereby agrees to defend the Lender and its officers,
directors, agents, employees, and counsel from, and hold each of them harmless
against, any and all losses, liabilities, claims, damages, interests, judgments,
costs (including without limitation cleanup costs) and expenses incurred by any
of them, including without limitation reasonable attorneys fees and
disbursements, arising out of or in connection with (i) the presence on or under
or the escape, seepage, leakage, spillage, discharge, emission, discharging or
release from, any real property owned or leased by the Borrower of any Hazardous
Materials caused by, or within the control of, the Borrower or claims asserted
or arising under any Environmental Laws, which may require the remediation of
such Hazardous Materials by the Borrower or the Lender or any successors or
assigns thereof, or (ii) any representation or warranty by the Borrower
contained in

                                       48
<PAGE>

Section 4.01(k) being false or untrue in any material respect.

         (b) If the Borrower receives any written notice of (i) a Hazardous
Discharge affecting the Borrower or its real properties or (ii) an Environmental
Complaint from any Person, including, without limitation, the United States
Environmental Protection Agency or any agency, department or authority of the
State of Florida, then the Borrower will give, within ten (10) Business Days,
oral and written notice of same to the Lender.

         (c) Without limitation of its rights under this Agreement, the Lender
shall have the right, but not the obligation after providing written notice to
Borrower and a reasonable opportunity for Borrower to respond, to enter onto any
of Borrower's real properties or in the event Borrower fails to act or respond,
to take such other reasonable actions as it deems reasonably necessary or
advisable to cleanup, remove, resolve or minimize the impact of, or otherwise
comply with Environmental Laws, or participate in such actions, in coordination
with Borrower for so long as no Event of Default exists, with respect to any
such Hazardous Discharge or Environmental Complaint upon its receipt of any
formal written notice from any Person, including, without

                                       49
<PAGE>

limitation, the United States Environmental Protection Agency, asserting the
existence of any Hazardous Discharge or Environmental Complaint on or pertaining
to any of the Borrower's real properties which, if true, could reasonably be
expected to result in an order, suit or other action against the Borrower
affecting any part of its real properties by any governmental agency or
otherwise and which could reasonably be expected to have a material adverse
effect on Borrower's operations or financial condition. All reasonable costs and
expenses incurred by the Lender in the exercise of any such rights herein shall
be payable by the Borrower upon demand, together with interest thereon at a rate
equal to the interest rate payable under the Note.

         (d) The indemnity obligations of the Borrower under this Section 7.03
shall survive payment of the Note.

         SECTION 7.04. LIMITATION ON LIABILITY OF LENDER. The Borrower hereby
waives any claim or defense arising out of or in any way related to the Loan
based upon the occurrence of any action or inaction of Lender on or prior to the
Closing Date which Borrower believes may (i) be actionable against Lender, or
(ii) give rise to a defense to payment hereunder or under the Note for any
reason, including without limitation, commission of a tort or

                                       50
<PAGE>

violation of any contractual duty or duty implied at law. Lender shall not be
responsible for any lost profits of Borrower arising from any breach of
contract, tort or any other wrong arising from the establishment, administration
or collection of the Loan.

                                  ARTICLE VIII
                                  MISCELLANEOUS

         SECTION 8.01. AMENDMENTS, ETC. No amendment or waiver of any provision
of any Loan Document, this Agreement or the Note, nor consent to any departure
by the Borrower therefrom, shall in any event be effective unless the same shall
be in writing and signed by the Lender, and then such waiver or consent shall be
effective only in the specific instance and for the specific purpose for which
given.

         SECTION 8.02. NOTICES, ETC. All notices and other communications
provided for hereunder shall be in writing (including telegraphic communication)
and mailed certified, return receipt requested, or telegraphed or delivered, if
to the Borrower, at its address at 1001 Brickell Bay Drive, 25th Floor, Miami,
FL 33131, Attention: President; if to the Lender, at its

                                       51
<PAGE>

address at Michael Jaharis, c/o Steven K. Aronoff, P.C., 475 Park Avenue South,
23rd Floor, New York, New York 10016, with a copy to Steven K. Aronoff, Esq. at
such address, or, as to each party, at such other address as shall be designated
by such party in a written notice to the other parties.

         SECTION 8.03. NO WAIVER; REMEDIES. No failure on the part of the Lender
to exercise, and no delay in exercising, any right under any Loan Document shall
operate as a waiver thereof; nor shall any single or partial exercise of any
right under any Loan Document preclude any other or further exercise thereof or
the exercise of any other right. The remedies provided in the Loan Documents are
cumulative and not exclusive of any remedies provided by law.

         SECTION 8.04. ACCOUNTING TERMS. Except as otherwise stated herein, all
accounting terms not specifically defined herein or in any schedule or exhibit
hereto shall be construed in accordance with generally accepted accounting
principles, applied on a consistent basis with those of the period ended
December 31, 1998, modified to reflect those changes in generally accepted
accounting principles as may be mutually accepted by Lender and Borrower for the
purposes of this Agreement.

                                       52
<PAGE>

         SECTION 8.05. RIGHT OF SET-OFF. Upon the occurrence and during the
continuance of any Event of Default, the Lender is hereby authorized at any time
and from time to time, without notice to the Borrower (any such notice being
expressly waived by the Borrower), to set-off and apply any and all indebtedness
at any time owing by the Lender to or for the credit or the account of the
Borrower against any and all of the obligations of the Borrower now or hereafter
existing under this Agreement and the Note, irrespective of whether or not the
Lender shall have made any demand under this Agreement or the Note. The Lender
agrees promptly to notify the Borrower after any such set-off and application
made by the Lender, provided that the failure to give such notice shall not
affect the validity of such set-off and application. The rights of the Lender
under this Section are in addition to other rights and remedies (including,
without limitation, other rights of set-off) which the Lender may have.

         SECTION 8.06. BINDING EFFECT; GOVERNING LAW. This Agreement shall
become effective when it shall have been executed by the Borrower and the Lender
and shall be binding upon and inure to the benefit of the Borrower, the Lender
and their respective successors and assigns, except that the Borrower shall not
have

                                       53
<PAGE>

the right to assign its rights hereunder or any interest herein without the
prior written consent of the Lender. This Agreement and the Note shall be
governed by, and construed in accordance with, the laws of the State of
Connecticut.

         SECTION 8.07. EXECUTION IN COUNTERPARTS. This Agreement may be executed
in any number of counterparts and by different parties hereto in separate
counterparts, each of which when so executed shall be deemed to be an original
and all of which when taken together shall constitute one and the same
agreement.

         SECTION 8.08. PARTIAL INVALIDITY. If any provision of this Agreement is
held to be invalid or unenforceable, such invalidity or unenforceability shall
not invalidate this Agreement as a whole but this Agreement shall be construed
as though it did not contain the particular provision or provisions held to be
invalid or unenforceable and the rights and obligations of the parties shall be
construed and enforced only to such extent as shall be permitted by law.

         SECTION 8.09. CONFLICTS. In the event that any provision of this
Agreement conflicts with any of the Loan Documents delivered in connection with
the transaction contemplated herein, the terms of this Agreement shall control,
notwithstanding any

                                       54
<PAGE>

such conflicts.

         SECTION 8.10. SURVIVAL. The representations and warranties contained
herein shall survive the execution of this Agreement by the parties herein.

         SECTION 8.11. WAIVER OF RIGHTS. BORROWER ACKNOWLEDGES THAT THE
TRANSACTION OF WHICH THIS NOTE IS A PART IS A COMMERCIAL TRANSACTION. BORROWER
HEREBY WAIVES, TO THE EXTENT PERMITTED BY LAW, THE BENEFITS OF ALL VALUATION,
APPRAISEMENT, HOMESTEAD, EXEMPTION, STAY, REDEMPTION AND MORATORIUM LAWS, NOW IN
FORCE OR WHICH MAY HEREAFTER BECOME LAW.

         SECTION 8.12. SUBMISSION TO JURISDICTION; WAIVER OF BOND. THE BORROWER
HEREBY CONSENTS TO THE JURISDICTION OF ANY LOCAL, STATE, OR FEDERAL COURT
LOCATED WITHIN THE STATE OF CONNECTICUT OR FLORIDA AND WAIVES ANY OBJECTION
WHICH THE BORROWER MAY HAVE BASED ON IMPROPER VENUE OR FORUM NON CONVENIENS, TO
THE CONDUCT OF ANY PROCEEDING IN ANY SUCH COURT AND WAIVES PERSONAL SERVICE OF
ANY AND ALL PROCESS UPON BORROWER, AND CONSENTS THAT ALL SUCH SERVICE OF PROCESS
BE MADE BY MAIL OR MESSENGER DIRECTED TO BORROWER AT THE ADDRESS SET FORTH IN
SECTION 8.02 ABOVE AND THAT SERVICE SO MADE SHALL BE DEEMED TO BE COMPLETED UPON
THE EARLIER OF ACTUAL RECEIPT OR THREE (3) DAYS AFTER THE SAME SHALL HAVE BEEN
POSTED TO

                                       55
<PAGE>

THE BORROWER'S ADDRESS. THE BORROWER WAIVES ANY BOND OR SURETY OR SECURITY UPON
SUCH BOND WHICH, MIGHT, BUT FOR THIS WAIVER, BE REQUIRED OF THE LENDER. NOTHING
CONTAINED IN THIS SECTION AFFECTS THE RIGHT OF THE LENDER TO SERVE LEGAL PROCESS
IN ANY OTHER MANNER PERMITTED BY LAW OR AFFECTS THE RIGHT OF THE LENDER TO BRING
ANY ACTION OR PROCEEDING AGAINST THE BORROWER OR BORROWER'S PROPERTY IN THE
COURTS OF ANY OTHER JURISDICTION.

         SECTION 8.13. WAIVER OF JURY TRIAL. THE BORROWER WAIVES, TO THE EXTENT
PERMITTED BY LAW, ANY RIGHT TO TRIAL BY JURY WHICH BORROWER MAY HAVE IN ANY
PROCEEDING BETWEEN LENDER AND BORROWER.

         SECTION 8.14. WAIVER OF PLAINTIFF'S RIGHT. THE BORROWER HEREBY AGREES
NOT TO COMMENCE ANY LEGAL PROCEEDING AGAINST THE LENDER IN THE JURISDICTION OF
ANY LOCAL, STATE OR FEDERAL COURT LOCATED WITHIN THE STATE OF FLORIDA UNLESS THE
LENDER EXPRESSLY CONSENTS THERETO IN WRITING.

                                       56
<PAGE>

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed by their respective officers thereunto duly authorized, as of the date
first above given.

                                                KOS PHARMACEUTICALS, INC.

                                                By:____________________________
                                                    Name:   Daniel M. Bell
                                                    Title:  President

                                                _______________________________
                                                MICHAEL JAHARIS

<PAGE>

STATE OF             )
                     )  ss.:
COUNTY OF            )

         On the ______ day of ___________, _____, before me came Daniel M. Bell,
to me known, who, being by me duly sworn, did depose and say that he resides at
No.________________ _______________________________________________; that he is
the President of Kos Pharmaceuticals, Inc., the corporation described in and
which executed, the foregoing instrument; that the foregoing instrument was
executed without corporate seal by order of the Board of Directors of said
corporation; that he signed his name thereto by like order.

                                                _______________________________
                                                Notary Public
                                                My commission expires:

STATE OF             )
                     )  ss.:
COUNTY OF            )

         On the ____ day of _________, ____, before me came Michael Jaharis, to
me known to be the individual described in, and who executed the foregoing
instrument, and acknowledged that he executed the same.

                                                _______________________________
                                                Notary Public
                                                My commission expires:

<PAGE>

                         LIST OF SCHEDULES AND EXHIBITS

SCHEDULES

A        -        LIST OF DEBTS AND LIENS

B        -        FINANCIAL COVENANTS

EXHIBITS

I        -        NOTE

II       -        REQUEST NOTICE

III      -        CORPORATE RESOLUTIONS OF BORROWER

IV       -        OPINION LETTER OF BORROWER'S COUNSEL

<PAGE>

                                   SCHEDULE B

                               FINANCIAL COVENANTS

         1. So long as the Note shall remain unpaid, the Borrower will not,
without the prior written consent of the Lender:

         (a) OPERATING EXPENSES. Incur operating expenses in any fiscal year
(exclusive of license fee payments) in excess of the following amounts
(determined on a cumulative basis):

                     -----------------------------------------------------------
                     AT END OF
                     -----------------------------------------------------------

                     -----------------------------------------------------------
                     1st Quarter                          $ 25,000,000
                     -----------------------------------------------------------
                     2nd Quarter                          $ 48,000,000
                     -----------------------------------------------------------
                     3rd Quarter                          $ 72,000,000
                     -----------------------------------------------------------
                     4th Quarter                          $ 95,000,000
                     -----------------------------------------------------------

         (b) CURRENT LIABILITIES. Permit the total of accounts payable and
accrued expenses to exceed $12,000,000 for a continuous period of more than 30
days or to exceed $14,000,000 at any one time.EXHIBIT 10.17

                           SECOND AMENDED AND RESTATED
                          REGISTRATION RIGHTS AGREEMENT

         This Second Amended and Restated Registration Rights Agreement (this
"Agreement") is made and entered into effective as of December 21, 1999, by and
between Kos Pharmaceuticals, Inc., a Florida corporation (the "Company"), Kos
Holdings, Inc., a Florida corporation ("Holdings"), Kos Investments, Inc., a
Florida corporation ("Investments"), and Michael Jaharis, an individual residing
in South Norwalk, Connecticut ("Jaharis") and effectively amends and restates
the Amended and Restated Registration Rights Agreement entered into by the
Company, Holdings and Investments dated as of September 1, 1999.

                                    RECITALS

         A.       Holdings has acquired 10,000,000 shares (the "Holdings
                  Shares") of the Company's common stock, par value $.01 per
                  share (the "Common Stock"), under the terms of an Assignment
                  and Assumption Agreement dated as of June 30, 1996 between the
                  Company and Holdings (the "Assignment Agreement"). Pursuant to
                  the Assignment Agreement, the Company has agreed to grant
                  Holdings certain registration rights in accordance with the
                  terms of this Agreement.

         B.       The Company has issued a Promissory Note dated July 1, 1996
                  (the "Investments Note"), to Investments for an aggregate
                  principal amount of $15,000,000, which has been converted to
                  shares of Common Stock (the "Investments Shares"). The Company
                  has granted Investments certain registration rights in
                  accordance with the terms of this Agreement.

         C.       The Company has issued a Promissory Note dated September 1,
                  1999 (the "September Jaharis Note") to Jaharis for an
                  aggregate principal amount of $50,000,000, which is
                  convertible to shares of Common Stock (the "Convertible Note
                  Shares"). Under the terms of the Jaharis Note, the Company has
                  granted Jaharis certain registration rights in accordance with
                  the terms of this Agreement.

         D.       The Company is issuing a Promissory Note of even date herewith
                  (the "January Jaharis Note") to Jaharis for an aggregate
                  principal amount of $50,000,000. In connection with the
                  January Jaharis Note, the Company

<PAGE>

                  is issuing a Warrant Agreement of even date herewith (the
                  "Warrant Agreement") pursuant to which Jaharis will receive
                  warrants to purchase shares of common stock (the "Warrant
                  Shares", and, together with the Holdings Shares, the
                  Investments Shares, the Convertible Note Shares, the "Shares")
                  Under the terms of the Warrant Agreement, the Company will
                  grant Jaharis certain registration rights in accordance with
                  the terms of this Agreement.

         NOW, THEREFORE, in consideration of the mutual promises and covenants
set forth herein, the parties hereto agree as follows:

         1. DEFINITIONS. The following terms shall have the meanings set forth
below:

               a. "COMMISSION" means the Securities and Exchange Commission, or
any other Federal agency at the time administering the Federal securities laws.

               b. "CONVERSION" means Jaharis' right to convert indebtedness
owing under the September Jaharis Note into the Convertible Note Shares as
provided in the September Loan Agreement and the September Jaharis Note.

               c. "CUTBACK REGISTRATION" means any registration in connection
with an underwritten public offering in which the managing underwriter advises
the Company that marketing factors require a limitation of the number of the
Company's securities to be underwritten in such public offering (including a
limitation to zero).

               d. "1933 ACT" means the Securities Act of 1933, as amended, or
any similar Federal statute, and the rules and regulations of the Commission
issued under such Act, as they each may, from time to time, be in effect.

               e. "1934 ACT" means the Securities Exchange Act of 1934 or any
similar Federal statute, and the rules and regulations of the Commission issued
under such Act, as they each may, from time to time, be in effect.

               f. "REGISTRATION RIGHTS HOLDER" means either Holdings,
Investments, or Jaharis, individually (collectively referred to as the
"Registration Rights Holders").

                                       2
<PAGE>

               g. "REGISTRATION STATEMENT" means a registration statement filed
by the Company with the Commission for a public offering and sale of securities
of the Company (other than any registration statement on Form S-4 or Form S-8,
or their successors, or any other form for a limited purpose, or any
registration statement covering only securities proposed to be issued in
exchange for securities or assets of another corporation or entity).

               h. "REGISTRATION EXPENSES" means the expenses described in
Section 4.

               i. "REGISTRABLE SHARES" means all of the Shares, and any other
shares of Common Stock or other securities of the Company or any other issuer
issued or issuable in respect of such Shares (because of stock splits, stock
dividends, reclassifications, recapitalizations, mergers, combinations or
similar events, if applicable); provided, HOWEVER, that the Shares which are
Registrable Shares shall cease to be Registrable Shares upon any sale or
transfer of such shares pursuant to a Registration Statement, Section 4(1) of
the 1933 Act, Rule 144 under the 1933 Act or otherwise, except that the Shares
which are Registrable Shares shall remain Registrable Shares notwithstanding any
transfer of the shares by Holdings or Investments to Jaharis or any of his
affiliates or by Jaharis or such affiliates to any member of Jaharis' immediate
family or to a trust established for the benefit of Jaharis or any family member
of Jaharis or to any corporation or other entity which is wholly owned by
Jaharis, such affiliates, such family members, or such trusts (Jaharis, such
affiliates, such family members such trusts and such entities referred to herein
collectively as "Permitted Transferees"). As a condition to effecting any
registration pursuant to this Agreement, the Company may require that Holdings,
Investments, Jaharis, or any Permitted Transferees, on whose behalf a
registration hereunder is being effected, execute an agreement further
acknowledging their obligations under Section 7 of this Agreement. All
references in this Agreement to the term "Holdings", "Investments" or "Jaharis"
shall be read to include any Permitted Transferee that owns or holds any
Registrable Shares.

               j. "SEPTEMBER LOAN AGREEMENT" shall mean that certain Revolving
Credit and Loan Agreement dated as of September 1, 1999 between the Company and
Jaharis providing for an extension of credit by Jaharis to the Company in the
principal amount of $50,000,000.

                                       3
<PAGE>

         2. REGISTRATION RIGHTS.

            a. REQUIRED REGISTRATIONS.

               i. Subject to the other provisions of this Agreement, Holdings,
Investments, and Jaharis shall each have the right to require the Company, upon
demand, whether before or after any indebtedness evidenced by the Investments
Note or the September Jaharis Note shall become convertible into Common Stock of
the Company, or whether before or after Jaharis shall exercise any warrants
pursuant to the Warrant Agreement, or whether before or after Investments or
Jaharis shall have become a holder of any Common Stock issued upon conversion
without registration under the 1933 Act, to effect unlimited registrations with
respect to the Registrable Shares (each such registration being a " Required
Registration"). To effect a Required Registration, a Registration Rights Holder
shall make a written request (a "Request Notice") to the Company with respect to
his or its Shares which shall describe in detail the contemplated sale of
Registerable Securities, including the number of Registerable Securities to be
registered. The Company shall be entitled to include in any Required
Registration shares of Common Stock to be sold by holders of either Common Stock
or rights to acquire Common Stock to whom the Company has previously granted or
in the future does grant any registration rights and shares of Common Stock to
be sold by the Company for its own account, provided that such inclusion shall
not limit the number of Registrable Shares included in such Registration
Statement.

               ii. Each Registration Rights Holder may revoke its Request Notice
in the event of a Cutback Registration that would limit the total number of
Registrable Shares that can be sold pursuant to such Requested Registration to a
number that is less than 90% of the number of the Registrable Shares specified
to be sold in the Request Notice.

               iii. The Company shall, as soon as practicable, but in no event
more than 120 days after receipt of a Request Notice, file a Registration
Statement covering the Registrable Shares to be included in the registration
requested by such Request Notice and cause such Registration Statement to become
effective as soon as practicable thereafter.

                                       4
<PAGE>

            b. PIGGYBACK REGISTRATION.

               i. At any time and from time to time after the date of this
Agreement, whenever the Company proposes to file a Registration Statement, the
Company will prior to such filing give written notice to all Registration Rights
Holders of its intention to do so and, upon the written request of any
Registration Rights Holders given within fifteen (15) days after the Company
provides such notice, the Company shall use its good faith efforts to cause all
Registrable Shares of such Registration Rights Holder which the Company has been
requested by such Registration Rights Holder to register, to be registered under
the 1933 Act to the extent necessary to permit their sale or other disposition
in accordance with the intended methods of distribution specified in the request
of such Registration Rights Holder; provided that the Company shall have the
right to postpone or withdraw any registration effected pursuant to this Section
2.b. without obligation to any Registration Rights Holder.

               ii. In connection with any registration under Section 2.b.
involving an underwritten offering of the Company's securities, the Company
shall not be required to include any Registrable Shares of a Registration Rights
Holder in such underwriting unless such Registration Rights Holder accepts the
terms of the underwriting as agreed upon between the Company and the
underwriters selected by it, and then only in such quantity as will not, in the
sole discretion of the underwriters, jeopardize the success of the offering by
the Company. If in the sole discretion of the managing underwriter or
underwriters the registration of all, or part of, the Registrable Shares which a
Registration Rights Holder has requested to be included would adversely affect
such public offering, then the Company shall be required to include in the
underwriting only that number of Registrable Shares, if any, which the managing
underwriter or underwriters believe may be sold without causing such adverse
effect. If the number of Registrable Shares to be included in the underwriting
in accordance with the foregoing is less than the total number of shares which
such Registration Rights Holder has requested to be included, then such
Registration Rights Holder shall participate in the underwriting pro rata based
upon such Registration Rights Holder's total ownership of Registrable Shares
compared to the total number of shares held by any other Registration Rights
Holder or other affiliates of the Company for which registration has been
requested whether or not such shares are the subject of separate agreements with
the Company concerning registration rights.

                                       5
<PAGE>

         3. REGISTRATION PROCEDURES. When the Company is required by the
provisions of this Agreement to effect the registration of any of the
Registrable Shares under the 1933 Act, the Company shall:

               a. file with the Commission a Registration Statement with respect
to such Registrable Shares and use its best efforts to cause that Registration
Statement to become and remain effective;

               b. as expeditiously as possible prepare and file with the
Commission any amendments and supplements to the Registration Statement and the
prospectus included in the Registration Statement as may be necessary to keep
the Registration Statement effective until the earlier to occur of (i) such time
as all Registrable Shares included therein have been sold or (ii) the expiration
of two years;

               c. as expeditiously as possible furnish to those Registration
Rights Holders whose Shares are being registered such reasonable numbers of
copies of the prospectus, including a preliminary prospectus and any amended or
supplemental prospectus, in conformity with the requirements of the 1933 Act,
and such other documents as such Registration Rights Holders may each reasonably
request in order to facilitate the public sale or other disposition of such
Registration Rights Holder's Registrable Shares; and

               d. as expeditiously as possible use its best efforts to register
or qualify the Registrable Shares covered by the Registration Statement under
the securities or Blue Sky laws of such states as the Registration Rights
Holders shall reasonably request, and do any and all other acts and things that
may be necessary or desirable to enable the Registration Rights Holders to
consummate the public sale or other disposition of the Registrable Shares owned
by the Registration Rights Holders in such jurisdiction; PROVIDED, HOWEVER, that
the Company shall not be required in connection with this Section 3 to qualify
as a foreign corporation in any jurisdiction nor register or qualify the
securities in any state which as a condition to such registration or
qualification would impose material restrictions or other material conditions on
the Company or any of its officers, directors or shareholders (including with
respect to any shares held by such persons or entities) unless such restrictions
or other conditions are approved by the party adversely affected.

                                       6
<PAGE>

         If the Company advises a Registration Rights Holder that any
preliminary or final prospectus is no longer in compliance with the requirements
of the 1933 Act, or that at such time it is otherwise a violation of any
applicable securities laws to offer or sell securities pursuant to a preliminary
or final prospectus, such Registration Rights Holder shall immediately cease
offering or selling the Registrable Securities and, if requested, return all old
prospectus to the Company. Such Registration Rights Holder may recommence offers
and sales of Registrable Securities upon receipt from the Company of an amended
prospectus, if applicable, or receipt of ratification from the Company that the
offer and sale of Registrable Securities may resume.

         4. ALLOCATION OF EXPENSES. The Company will pay all Registration
Expenses of all registrations under this Agreement. The term "Registration
Expenses" shall mean all expenses incurred by the Company in complying with this
Agreement, including, without limitation, all registration and filing fees,
exchange listing fees, printing expenses, fees and disbursements of counsel for
the Company, state Blue Sky fees and expenses, and the expense of any special
audits incident to or required by any such registration, but excluding
underwriting discounts and selling commissions attributable to the Registrable
Shares and the fees and expenses of each Registration Rights Holder's own
counsel and accountants, which shall be borne by such Registration Rights
Holder.

         5. INFORMATION BY REGISTRATION RIGHTS HOLDERS. Each Registration Rights
Holder shall promptly furnish to the Company such information regarding such
Registration Rights Holder and the distribution proposed by such Registration
Rights Holder as the Company may request in writing and as shall be required in
connection with any registration, qualification or compliance referred to in
this Agreement.

         6. "LOCK-UP" AGREEMENT. If requested by an underwriter in connection
with an underwritten offering of Common Stock or other securities of the
Company, each Registration Rights Holder shall agree not to sell or otherwise
transfer or dispose of any Registrable Shares or other securities of the Company
held by such Registration Rights Holder for a specified period of time before
and/or after the effective date of a Registration Statement, PROVIDED that the
same request shall have been made of other holders of the Company's Common Stock
or other securities (including affiliates of the Company) and such other holders
have complied with such request. Such agreement shall

                                       7
<PAGE>

be in writing in a form satisfactory to the Company and any such underwriter.
The Company may impose stop transfer instructions with respect to the
Registrable Shares or other securities subject to the foregoing restriction
until the end of the lock-up period.

         7. INDEMNIFICATION.

            a. BY THE COMPANY. In the event of any registration of any of the
Registrable Shares under the 1933 Act pursuant to this Agreement, the Company
will indemnify and hold harmless the sellers of such Registrable Shares against
any losses, claims, damages or liabilities, joint or several, to which such
sellers may become subject under the 1933 Act, 1934 Act, state securities laws
or otherwise, insofar as such losses, claims, damages or liabilities (or actions
in respect thereof) arise out of or are based upon any untrue statement of any
material fact contained in any Registration Statement under which such
Registrable Shares were registered under the 1933 Act, any preliminary
prospectus or final prospectus contained in the Registration Statement, or any
amendment or supplement to such Registration Statement, or arise out of or are
based upon the omission to state a material fact required to be stated therein
or necessary to make the statements therein not misleading; and the Company will
reimburse such sellers for any legal or any other expenses reasonably incurred
by such sellers in connection with investigating and defending any such loss,
claim, damage, liability or action; PROVIDED, HOWEVER, that the Company will not
be liable in any such case to the extent that any such loss, claim, damage,
liability or expense arises out of or is based upon any untrue statement or
omission made in such Registration Statement, preliminary prospectus or
prospectus, or any such amendment or supplement, in reliance upon and in
conformity with information furnished to the Company by or on behalf of such
sellers, specifically for use in the preparation thereof, or as a result of the
failure of such sellers, or any agent of such sellers, to deliver any amendments
and supplements to any Registration Statement and the prospectus included in any
such Registration Statement (provided such amended or supplemental prospectus
has been delivered to sellers or their agent).

            b. BY SELLERS OF REGISTRABLE SHARES. In the event of any
registration of any of the Registrable Shares under the 1933 Act pursuant to
this Agreement, each seller of Registrable Shares, severally and not jointly,
will indemnify and hold harmless the Company, each of its directors and officers
and each underwriter (if any) and each person, if any, who controls

                                       8
<PAGE>

the Company or any such underwriter within the meaning of the 1933 Act or the
1934 Act, against any losses, claims, damages or liabilities, joint or several,
to which the Company, such directors and officers, underwriter or controlling
person may become subject under the 1933 Act, 1934 Act, state securities laws or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon any untrue statement of a
material fact contained in any Registration Statement under which such
Registrable Shares were registered under the 1933 Act, any preliminary
prospectus or final prospectus contained in the Registration Statement, or any
amendment or supplement to the Registration Statement, or arise out of or are
based upon any omission or alleged omission to state a material fact required to
be stated therein or necessary to make the statements therein not misleading,
and each seller of Registrable Shares will reimburse the Company, each of its
directors and officers, each underwriter and each controlling person, severally
and not jointly, for any legal or other expenses reasonably incurred by the
Company, each director and officer, each underwriter and each controlling person
in connection with investigating and defending any such loss, claim, damage,
liability or action, if the statement or omission was made in reliance upon and
in conformity with information furnished to the Company by or on behalf of such
seller, specifically for use in connection with the preparation of such
Registration Statement, prospectus, amendment or supplement.

            c. CLAIMS. Each party entitled to indemnification under this Section
7 (the "Indemnified Party") shall give notice to the party required to provide
indemnification (the "Indemnifying Party") promptly after such Indemnified Party
has actual knowledge of any claim as to which indemnity may be sought, and shall
permit the Indemnifying Party to assume the defense of any such claim or any
litigation resulting therefrom; PROVIDED, that counsel for the Indemnifying
Party, who shall conduct the defense of such claim or litigation, shall be
approved by the Indemnified Party (whose approval shall not be unreasonably
withheld); and, PROVIDED, further, that the failure of any Indemnified Party to
give notice as provided herein shall not relieve the Indemnifying Party of its
obligations under this Section 7. The Indemnified Party may participate in such
defense at such party's expense. No Indemnifying Party, in the defense of any
such claim or litigation, except with the consent of the Indemnified Party,
shall consent to entry of any judgment or enter into any settlement, which does
not include as an unconditional term thereof the giving by the claimant or

                                       9
<PAGE>

plaintiff to such Indemnified Party of a release from all liability in respect
of such claim or litigation.

         8. MERGERS, ETC.

            The Company shall not, directly or indirectly, enter into any
merger, consolidation or reorganization in which the Company shall not be the
surviving corporation unless the proposed surviving corporation shall, prior to
such merger, consolidation or reorganization, agree in writing to assume the
obligations of the Company under this Agreement, and for that purpose references
hereunder to "Registrable Shares" shall be deemed to be references to the
securities which either Registration Rights Holder would be entitled to receive
in exchange for Registrable Shares under any such merger, consolidation or
reorganization; provided, however, that the provisions of this Section 8 shall
not apply in the event of any merger, consolidation or reorganization in which
the Company is not the surviving corporation if all Registration Rights Holders
and all other holders of Common Stock of the Company are entitled to receive in
exchange for their Registrable Shares consideration consisting solely of (i)
cash, (ii) securities of the acquiring corporation which may be immediately sold
to the public without registration under the Securities Act, or (iii) securities
of the acquiring corporation which the acquiring corporation has agreed to
register within 90 days of completion of the transaction for resale to the
public pursuant to the Securities Act.

         9. MISCELLANEOUS.

            a. GOVERNING LAW. This Agreement shall be governed in all respects
by the laws of the state of Connecticut.

            b. SUCCESSORS AND ASSIGNS. Except as otherwise expressly provided
herein, the provisions hereof shall inure to the benefit of, and be binding
upon, the successors, assigns, heirs, executors and administrators of the
parties hereto.

            c. ENTIRE AGREEMENT; AMENDMENT; WAIVER. This Agreement constitutes
the full and entire understanding and agreement between the parties with regard
to the subjects hereof. Neither this Agreement nor any term hereof may be
amended, waived, discharged or terminated, except by a written instrument signed
by the Company, and each Registration Rights Holder affected by such change. No
waivers of or exceptions to any term, condition or provision of this Agreement,
in any one

                                       10
<PAGE>

or more instances, shall be deemed to be, or construed as, a further or
continuing waiver of any such term, condition or provision.

            d. NOTICES, ETC. All notices and other communications required or
permitted hereunder shall be in writing and shall be mailed by United States
first-class certified or registered mail, return receipt requested, postage
prepaid, or delivered personally by hand or nationally recognized courier
addressed as follows:

         If to Holdings:

                           C/o Steven J. Aronoff, P.C.,
                           475 Park Avenue South, 23rd Floor
                           New York, New York 10016

         If to Investments:

                           C/o Steven J. Aronoff, P.C.,
                           475 Park Avenue South, 23rd Floor
                           New York, New York 10016

         If to Jaharis:

                           Michael Jaharis
                           C/o Steven J. Aronoff, P.C.,
                           475 Park Avenue South, 23rd Floor
                           New York, New York 10016

         If to the Company:

                           Kos Pharmaceuticals, Inc.
                           1001 Brickell Bay Drive
                           Suite 2502
                           Miami, Florida 33131
                           Facsimile No.  (305) 577-4596
                           Attention:  Daniel M. Bell, President

or at such other address as a party shall have furnished to the other party in
writing. All such notices and other written communications shall be effective on
the earlier of the date of mailing or delivery.

            e. SEVERABILITY. In case any provision of this Agreement shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions shall not in any way be affected or impaired thereby.

                                       11
<PAGE>

            f. TITLES AND SUBTITLES. The titles of the paragraphs and
subparagraphs of this Agreement are for convenience of reference only and are
not to be considered in construing this Agreement.

            g. COUNTERPARTS. This Agreement may be executed in any number of
counterparts, each of which shall be an original, and all of which together
shall constitute one instrument.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement
effective as of the day and year first above written.

                                     COMPANY

                                     KOS PHARMACEUTICALS, INC.

                                     By:________________________________________
                                            Daniel M. Bell, President

                                     KOS HOLDINGS, INC.

                                     By:________________________________________

                                     KOS INVESTMENTS, INC.

                                     By:________________________________________

                                       _________________________________________
                                       MICHAEL JAHARIS

                                       12

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