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                                                                   EXHIBIT 10.45

                                FIRST AMENDMENT
                                       TO
                          SECOND AMENDED AND RESTATED
                           PER-SE TECHNOLOGIES, INC.
                        NON-QUALIFIED STOCK OPTION PLAN

         THIS FIRST AMENDMENT TO THE SECOND AMENDED AND RESTATED PER-SE
TECHNOLOGIES, INC. NON-QUALIFIED STOCK OPTION PLAN is made as of February 24,
2000, by Per-Se Technologies, Inc., a Delaware corporation (the "Company").

                              W I T N E S S E T H:

         WHEREAS, the Company has previously adopted the Second Amended and
Restated Per-Se Technologies, Inc. Non-Qualified Stock Option Plan (the "Plan");
and

         WHEREAS, the Company desires to amend the Plan in order to prohibit
the repricing of options outstanding under the Plan.

         NOW, THEREFORE, the Plan is hereby amended by deleting Section 8
thereof in its entirety and substituting in lieu thereof the following new
Section 8:

                  "8.      Amendments.

                           (a)      Amendment of the Plan. The Plan may be
                  amended by the Committee from time to time to the extent that
                  the Committee deems necessary or appropriate except that the
                  Committee shall not amend the Plan, absent the approval of
                  the stockholders of the Company (i) to materially increase
                  (within the meaning of Rule 16b-3) the benefits accruing to
                  participants under the Plan, (ii) to materially increase
                  (within the meaning of Rule 16b-3) the number of securities
                  which may be issued under the Plan, or (iii) to materially
                  modify (within the meaning of Rule 16b-3) the requirements as
                  to eligibility for participation in the Plan; provided,
                  however, that if the amendment would not alter the rights of
                  any participant under the Plan who is subject to Rule 16b-3,
                  then the Committee may approve such amendment without
                  obtaining the approval of the stockholders of the Company;
                  and provided, further however, the Committee shall have the
                  authority, for any employee who is not subject to Rule 16b-3,
                  to modify the three (3) and six (6) month time periods set
                  forth in Section 5(f) of the Plan without obtaining the
                  approval of the stockholders of the Company.

                           (b)     Amendment of Outstanding Options.  The Board
                  of Directors, acting through the Committee shall have the
                  power to amend any outstanding option; provided, however,
                  that the Committee shall not

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                  have to power to amend any outstanding option that would
                  alter the rights of the holder of such option to the
                  detriment of such holder without such holder's prior written
                  consent and, provided further, that the Committee shall not
                  have the power to reprice any outstanding option."

                  FURTHER, except as specifically amended by this First
Amendment, the Plan shall remain in full force and effect as prior to this
First Amendment.

                  IN WITNESS WHEREOF, the Company has caused this First
Amendment to be executed as of the day and year first above written.

                                    PER-SE TECHNOLOGIES, INC.

                                    By:  /s/ ALLEN W. RITCHIE
                                         ---------------------
                                         Allen W. Ritchie
                                         President and Chief Executive Officer

ATTEST:

By:  /s/ RANDOLPH L. M. HUTTO
     ------------------------
     Randolph L. M. Hutto
     Secretary<PAGE>   1
                                                                   EXHIBIT 10.46

                                FOURTH AMENDMENT
                                       TO
                    NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN

         THIS FOURTH AMENDMENT (the "Fourth Amendment") is made effective as of
February 24, 2000, by PER-SE TECHNOLOGIES, INC., a Delaware corporation
formerly known as Medaphis Corporation (the "Company").

                              W I T N E S S E T H

         WHEREAS, the Company has previously adopted the Per-Se Technologies
Non-Employee Director Stock Option Plan, as amended (the "Plan");

         WHEREAS, the Board of Directors of the Company has duly authorized and
approved, subject to the approval of the Company's stockholders, the Third
Amendment to the Plan increasing the number of shares authorized to be issued
under the Plan to 283,333 shares;

         WHEREAS, the Board of Directors of the Company has duly authorized an
amendment of the Plan to grant the Board discretion in determining the number
of shares to be granted to non-employee directors of the Company and, subject
to approval by the Company's stockholders of the increase in shares authorized
to be issued under the Plan, to increase the initial and annual grants of
options to non-employee directors to 10,000 shares each, subject to the Board's
discretion to increase or decrease such awards from time to time or at any time
and to provide for a special one-time grant to existing directors in light of
the increase in the initial grant;

         NOW, THEREFORE, Section 1 of the Plan is amended by deleting the last
sentence thereof and substituting in lieu thereof the following:

         "This Plan is intended to comply with Rule 16b-3."

         FURTHER, the Plan is hereby amended by deleting Section 2 of the Plan
in its entirety and substituting in lieu thereof the following:

                  2.       Administration. This Plan shall be administered by
         the Board of Directors of the Company (the "Board"). The Board shall
         have no authority, discretion or power to select the Non-Employee
         Directors who will receive options (the "Options") to purchase shares
         of voting common stock, par value $.01 per share, of the Company (the
         "Common Stock") hereunder or to set or re-set the exercise price of
         such Option or the period within which such Option may be exercised,
         except in the sense of administering this Plan pursuant to its express
         terms. The Board shall have the authority, discretion and power to set
         the number of shares of Common Stock to be covered by each Option
         granted hereunder, and to set the timing of the grant of any option
         hereunder and to make

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         special grants in addition to the initial and annual grants from time
         to time and at any time. Subject to the foregoing and the provisions
         of Section 16b) of the Exchange Act, and Rule 16b-3, the Board shall
         have the authority to interpret and construe the provisions of this
         Plan and of any agreements issued hereunder and make determinations
         pursuant to any Plan provision or agreement. The Board shall interpret
         and administer the provisions of this Plan or any agreement issued
         hereunder in a manner consistent with the intentions referred to in
         Section 1 hereof and any provisions of this Plan or any such agreement
         inconsistent therewith shall be inoperative and shall not affect the
         validity of this Plan. The Board shall have the power to place
         transfer and other restrictions on the Options as may be required by
         federal and state securities laws. Each interpretation, determination
         or other action made or taken pursuant to the Plan by the Board shall
         be final, conclusive and binding on all persons.

         FURTHER, the Plan is hereby amended by deleting the figure 5,000 in
the first line of Section 5(b)(1) of the Plan and substituting in lieu thereof
the figure 10,000.

         FURTHER, the Plan is hereby amended by deleting Section 5(b)(2) in its
entirety and substituting in lieu thereof the following:

                  (2)      Annual Grants. An Option to purchase 10,000 Shares or
         such other number of Shares as the Board may determine in its
         discretion (an "Annual Grant") shall be granted each year immediately
         following the Annual Meeting, or at such other time as the Board in
         its discretion may determine, to each Non-Employee Director serving as
         such, other than a Non-Employee Director then receiving an Initial
         Grant under Section 5(b)(1)(ii)(1) hereof.

         FURTHER, the Plan is hereby amended by adding to Section 5(b) a new
subsection 5(b)(3) as follows:

                  (3)      Special Grant. An Option to purchase 10,000 Shares
         shall be granted to each Director eligible to participate in this Plan
         as of February 24, 2000, such Option to be granted as of such date
         with an exercise price equal to the average of the Fair Market
         Values of the Common Stock for the five (5) trading days prior to
         February 24, 2000.

provided, however, that the increase in the Initial and Annual Grants and the
Special Grant reflected in the foregoing amendment shall be subject to and
conditioned upon approval by the stockholders of the Company at the 2000 Annual
Meeting of Stockholders or any adjournment thereof of the increase in shares
available for grant reflected in the Third Amendment to the Plan.

         FURTHER, except as specifically amended by this Fourth Amendment, the
Plan shall remain in full force and effect as prior to this Fourth Amendment.

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         IN WITNESS WHEREOF, the Company has caused this Fourth Amendment to be
executed as of the day and year first above written.

                                           PER-SE TECHNOLOGIES, INC.

                                           By: /s/ ALLEN W. RITCHIE
                                               -----------------------
                                               Allen W. Ritchie, President and
                                               Chief Executive Officer
ATTEST:

By: /s/ RANDOLPH L. M. HUTTO
    ---------------------------
    Randolph L. M. Hutto
    Secretary

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