Document:

Exhibit 4.6

 

WARRANT AGENT AGREEMENT

 

WARRANT AGENT AGREEMENT (this “Warrant
Agreement”) dated as of _________, 2016 (the “Issuance Date”) between Aytu Bioscience, Inc., a company
incorporated under the laws of the State of Delaware (the “Company”), and VStock Transfer, LLC (the “Warrant
Agent”).

 

WHEREAS, pursuant to the terms of that
certain Underwriting Agreement (“Underwriting Agreement”), dated _________, 2016, by and among the Company and
Joseph Gunnar & Co., LLC, as representative of the underwriters set forth therein, the Company is engaged in a public offering
(the “Offering”) of up to _________ shares (the “Shares”) of common stock, par value $0.0001
per share (the “Common Stock”) of the Company and up to _________ Warrants (the “Warrants”)
to purchase shares of Common Stock (the “Warrant Shares”), including Shares and Warrants issuable pursuant to
the underwriters over-allotment option;

  

WHEREAS, the Company has filed with the
Securities and Exchange Commission (the “Commission”) a Registration Statement, No. 333-213738, on Form S-1
(as the same may be amended from time to time, the “Registration Statement”), for the registration under the
Securities Act of 1933, as amended (the “Securities Act”), of the Shares, Warrants and Warrant Shares, and such
Registration Statement was declared effective on _______, 2016;

 

WHEREAS, the Company desires the Warrant
Agent to act on behalf of the Company, and the Warrant Agent is willing to so act, in accordance with the terms set forth in this
Warrant Agreement in connection with the issuance, registration, transfer, exchange and exercise of the Warrants;

 

WHEREAS, the Company desires to provide
for the provisions of the Warrants, the terms upon which they shall be issued and exercised, and the respective rights, limitation
of rights, and immunities of the Company, the Warrant Agent, and the holders of the Warrants; and

 

WHEREAS, all acts and things have been
done and performed which are necessary to make the Warrants the valid, binding and legal obligations of the Company, and to authorize
the execution and delivery of this Warrant Agreement.

 

NOW, THEREFORE, in consideration of the
mutual agreements herein contained, the parties hereto agree as follows:

 

1. Appointment of Warrant Agent.
The Company hereby appoints the Warrant Agent to act as agent for the Company with respect to the Warrants, and the Warrant Agent
hereby accepts such appointment and agrees to perform the same in accordance with the express terms and conditions set forth in
this Warrant Agreement (and no implied terms or conditions).

 

2. Warrants.

 

2.1 Form of Warrants. The Warrants
shall be registered securities and shall be evidenced by a global certificate (“Global Certificate”) in the
form of Annex A to this Warrant Agreement, which shall be deposited on behalf of the Company with a custodian
for The Depository Trust Company (“DTC”) and registered in the name of Cede & Co., a nominee of DTC. If
DTC subsequently ceases to make its book-entry settlement system available for the Warrants, the Company may instruct the Warrant
Agent regarding making other arrangements for book-entry settlement. In the event that the Warrants are not eligible for, or it
is no longer necessary to have the Warrants available in, book-entry form, the Company may instruct the Warrant Agent to provide
written instructions to DTC to deliver to the Warrant Agent for cancellation the Global Certificate, and the Company shall instruct
the Warrant Agent to deliver to DTC separate certificates evidencing Warrants (“Definitive Certificates” and,
together with the Global Certificate, “Warrant Certificates”) registered as requested through the DTC system.

 

     

     

    

 

2.2. Issuance and Registration
of Warrants.

 

2.2.1. Warrant Register. The
Warrant Agent shall maintain books (“Warrant Register”) for the registration of original issuance and the registration
of transfer of the Warrants.

 

2.2.2. Issuance of Warrants.
Upon the initial issuance of the Warrants, the Warrant Agent shall issue the Global Certificate and deliver the Warrants in the
DTC book-entry settlement system in accordance with written instructions delivered to the Warrant Agent by the Company. Ownership
of security entitlements in the Warrants shall be shown on, and the transfer of such ownership shall be effected through, records
maintained (i) by DTC and (ii) by institutions that have accounts with DTC (each, a “Participant”).

 

2.2.3. Beneficial Owner; Holder.
Prior to due presentment for registration of transfer of any Warrant, the Company and the Warrant Agent may deem and treat the
person in whose name that Warrant shall be registered on the Warrant Register (the “Holder”) as the absolute
owner of such Warrant for purposes of any exercise thereof, and for all other purposes, and neither the Company nor the Warrant
Agent shall be affected by any notice to the contrary. Notwithstanding the foregoing, nothing herein shall prevent the Company,
the Warrant Agent or any agent of the Company or the Warrant Agent from giving effect to any written certification, proxy or other
authorization furnished by DTC governing the exercise of the rights of a holder of a beneficial interest in any Warrant. The rights
of beneficial owners in a Warrant evidenced by the Global Certificate shall be exercised by the Holder or a Participant through
the DTC system, except to the extent set forth herein or in the Global Certificate.

 

2.2.4. Execution. The Warrant
Certificates shall be executed on behalf of the Company by any authorized officer of the Company (an “Authorized Officer”),
which need not be the same authorized signatory for all of the Warrant Certificates, either manually or by facsimile signature.
The Warrant Certificates shall be countersigned by an authorized signatory of the Warrant Agent, which need not be the same signatory
for all of the Warrant Certificates, and no Warrant Certificate shall be valid for any purpose unless so countersigned. In case
any Authorized Officer of the Company that signed any of the Warrant Certificates ceases to be an Authorized Officer of the Company
before countersignature by the Warrant Agent and issuance and delivery by the Company, such Warrant Certificates, nevertheless,
may be countersigned by the Warrant Agent, issued and delivered with the same force and effect as though the person who signed
such Warrant Certificates had not ceased to be such officer of the Company; and any Warrant Certificate may be signed on behalf
of the Company by any person who, at the actual date of the execution of such Warrant Certificate, shall be an Authorized Officer
of the Company authorized to sign such Warrant Certificate, although at the date of the execution of this Warrant Agreement any
such person was not such an Authorized Officer.

 

2.2.5. Registration of Transfer.
At any time at or prior to the Expiration Date (as defined below), a transfer of any Warrants may be registered and any Warrant
Certificate or Warrant Certificates may be split up, combined or exchanged for another Warrant Certificate or Warrant Certificates
evidencing the same number of Warrants as the Warrant Certificate or Warrant Certificates surrendered. Any Holder desiring to register
the transfer of Warrants or to split up, combine or exchange any Warrant Certificate shall make such request in writing delivered
to the Warrant Agent, and shall surrender to the Warrant Agent the Warrant Certificate or Warrant Certificates evidencing the Warrants
the transfer of which is to be registered or that is or are to be split up, combined or exchanged and, in the case of registration
of transfer, shall provide a signature guarantee. Thereupon, the Warrant Agent shall countersign and deliver to the person entitled
thereto a Warrant Certificate or Warrant Certificates, as the case may be, as so requested. The Company and the Warrant Agent may
require payment, by the Holder requesting a registration of transfer of Warrants or a split-up, combination or exchange of a Warrant
Certificate (but, for purposes of clarity, not upon the exercise of the Warrants and issuance of Warrant Shares to the Holder),
of a sum sufficient to cover any tax or governmental charge that may be imposed in connection with such registration of transfer,
split-up, combination or exchange, together with reimbursement to the Company and the Warrant Agent of all reasonable expenses
incidental thereto.

 

     

     

    

 

2.2.6. Loss, Theft and Mutilation
of Warrant Certificates. Upon receipt by the Company and the Warrant Agent of evidence reasonably satisfactory to them of the
loss, theft, destruction or mutilation of a Warrant Certificate, and, in case of loss, theft or destruction, of indemnity or security
in customary form and amount, and reimbursement to the Company and the Warrant Agent of all reasonable expenses incidental thereto,
and upon surrender to the Warrant Agent and cancellation of the Warrant Certificate if mutilated, the Warrant Agent shall, on behalf
of the Company, countersign and deliver a new Warrant Certificate of like tenor to the Holder in lieu of the Warrant Certificate
so lost, stolen, destroyed or mutilated. The Warrant Agent may charge the Holder an administrative fee for processing the replacement
of lost Warrant Certificates, which shall be charged only once in instances where a single surety bond obtained covers multiple
certificates. The Warrant Agent may receive compensation from the surety companies or surety agents for administrative services
provided to them.

  

2.2.7. Proxies. The Holder
of a Warrant may grant proxies or otherwise authorize any person, including the Participants and beneficial holders that may own
interests through the Participants, to take any action that a Holder is entitled to take under this Agreement or the Warrants; provided, however,
that at all times that Warrants are evidenced by a Global Certificate, exercise of those Warrants shall be effected on their behalf
by Participants through DTC in accordance the procedures administered by DTC.

 

3. Terms and Exercise of Warrants.

 

3.1. Exercise Price. Each Warrant
shall entitle the Holder, subject to the provisions of the applicable Warrant Certificate and of this Warrant Agreement, to purchase
from the Company the number of shares of Common Stock stated therein, at the price of $____ per whole share, subject to the subsequent
adjustments provided in Section 4 hereof. The term “Exercise Price” as used in this Warrant Agreement refers
to the price per share at which shares of Common Stock may be purchased at the time a Warrant is exercised.

 

3.2. Duration of Warrants.
Warrants may be exercised only during the period (“Exercise Period”) commencing on the Issuance Date and terminating
at 5:00 P.M., New York City time (the “close of business”) on ______, 2021 (“Expiration
Date”). Each Warrant not exercised on or before the Expiration Date shall become void, and all rights thereunder and
all rights in respect thereof under this Warrant Agreement shall cease at the close of business on the Expiration Date.

 

3.3. Exercise of Warrants.

 

3.3.1. Exercise and Payment.

 

(a) Subject to the
provisions of this Warrant Agreement, a Holder (or a Participant or a designee of a Participant acting on behalf of a Holder) may
exercise Warrants by delivering to the Warrant Agent, not later than 5:00 P.M., New York City time, on any business day during
the Exercise Period an election to purchase the Warrant Shares underlying the Warrants to be exercised (A) in the form included
in Annex B to this Warrant Agreement or (B) via an electronic warrant exercise through the DTC system (each, an “Election
to Purchase”). No later than one (1) Trading Day following delivery of an Election to Purchase, the Holder (or a Participant
acting on behalf of a Holder in accordance with DTC procedures) shall (i) (A) surrender of the Warrant Certificate evidencing the
Warrants to the Warrant Agent at its office designated for such purpose or (B) delivery of the Warrants to an account of the Warrant
Agent at DTC designated for such purpose in writing by the Warrant Agent to DTC from time to time, and (ii) deliver to the Company
the Exercise Price for each Warrant to be exercised, in lawful money of the United States of America by certified or official bank
check payable to the Company or bank wire transfer in immediately available funds to:

 

___________________

___________________

___________________

___________________

 

     

     

    

 

Any person so designated
by the Holder (or a Participant or designee of a Participant on behalf of a Holder) to receive Warrant Shares shall be deemed to
have become holder of record of such Warrant Shares as of the time that an appropriately completed and duly signed Election to
Purchase has been delivered to the Warrant Agent, provided that the Holder (or Participant on behalf of the Holder) makes delivery
of the deliverables referenced in the immediately preceding sentence by the date that is one (1) Trading Day after the delivery
of the Election to Purchase. If the Holder (or Participant on behalf of the Holder) fails to make delivery of such deliverables
on or prior to the Trading Day following delivery of the Election to Purchase, such Election to Purchase shall be void ab initio. 

 

(b) If any of (i) the
Warrants, (ii) the Election to Purchase, or (iii) the Exercise Price therefor, is received by the Warrant Agent on any date after
5:00 P.M., New York City time, or on a date that is not a Trading Day, the Warrants with respect thereto will be deemed to have
been received and exercised on the Trading Day next succeeding such date. “Business day” means a day other than
a Saturday or Sunday on which commercial Banks in New York City are open for the general conduct of banking business. The “Exercise
Date” will be the date on which the materials in the foregoing sentence are received by the Warrant Agent (if by 5:00
P.M., New York City time), or the following Trading Day (if after 5:00 P.M., New York City time), regardless of any earlier date
written on the materials. If the Warrants are received or deemed to be received after the Expiration Date, the exercise thereof
will be null and void and any funds delivered to the Company will be returned to the Holder or Participant, as the case may be,
as soon as practicable. In no event will interest accrue on any funds deposited with the Company in respect of an exercise or attempted
exercise of Warrants.

 

(c) [Reserved.]

 

(d) If less than all
the Warrants evidenced by a surrendered Warrant Certificate are exercised, the Warrant Agent shall split up the surrendered Warrant
Certificate and return to the Holder a Warrant Certificate evidencing the Warrants that were not exercised.

 

3.3.2. Issuance of Warrant Shares.
(a) The Warrant Agent shall, by 11:00 a.m., New York City time, on the Trading Day following the Exercise Date of any Warrant,
advise the Company, the transfer agent and registrar for the Company’s Common Stock, in respect of (i) the number of Warrant
Shares indicated on the Election to Purchase as issuable upon such exercise with respect to such exercised Warrants, (ii) the instructions
of the Holder or Participant, as the case may be, provided to the Warrant Agent with respect to the delivery of the Warrant Shares
and the number of Warrants that remain outstanding after such exercise and (iii) such other information as the Company or such
transfer agent and registrar shall reasonably request.

 

(b) The Company shall, by no later than
5:00 P.M., New York City time, on the third Trading Day following the Exercise Date of any Warrant and the clearance of the funds
in payment of the Exercise Price (such date and time, the “Delivery Time”), cause its registrar to electronically
transmit the Warrant Shares issuable upon that exercise to DTC by crediting the account of DTC or of the Participant, as the
case may be, through its Deposit Withdrawal Agent Commission system.

 

3.3.3. Valid Issuance. All
Warrant Shares issued by the Company upon the proper exercise of a Warrant in conformity with this Warrant Agreement shall be validly
issued, fully paid and non-assessable.

 

3.3.4. No Fractional Exercise.
No fractional Warrant Shares will be issued upon the exercise of the Warrant. If, by reason of any adjustment made pursuant to
Section 4, a Holder would be entitled, upon the exercise of such Warrant, to receive a fractional interest in a share, the Company
shall, upon such exercise, round up or down, as applicable, to the nearest whole number the number of Warrant Shares to be issued
to such Holder.

 

3.3.5 No Transfer Taxes. The
Company shall not be required to pay any stamp or other tax or governmental charge required to be paid in connection with any transfer
involved in the issue of the Warrant Shares upon the exercise of Warrants; and in the event that any such transfer is involved,
the Company shall not be required to issue or deliver any Warrant Shares until such tax or other charge shall have been paid or
it has been established to the Company’s satisfaction that no such tax or other charge is due.

 

     

     

    

 

3.3.6 Date of Issuance. The
Company will treat an exercising Holder as a beneficial owner of the Warrant Shares as of the Exercise Date, except that, if the
Exercise Date is a date when the stock transfer books of the Company are closed, such person shall be deemed to have become the
holder of such shares at the open of business on the next succeeding date on which the stock transfer books are open.

 

3.3.7 Restrictive Legend Events;
Cashless Exercise Under Certain Circumstances.

 

(i) The Company shall use it reasonable
best efforts to maintain the effectiveness of the Registration Statement and the current status of the prospectus included therein
or to file and maintain the effectiveness of another registration statement and another current prospectus covering the Warrants
and the Warrant Shares at any time that the Warrants are exercisable. The Company shall provide to the Warrant Agent and each Holder
prompt written notice of any time that the Company is unable to deliver the Warrant Shares via DTC transfer or otherwise without
restrictive legend because (A) the Commission has issued a stop order with respect to the Registration Statement, (B) the Commission
otherwise has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, (C) the
Company has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, (D) the
prospectus contained in the Registration Statement is not available for the issuance of the Warrant Shares to the Holder or (E)
otherwise (each a “Restrictive Legend Event”). To the extent that the Warrants cannot be exercised as a result
of a Restrictive Legend Event or a Restrictive Legend Event occurs after a Holder has exercised Warrants in accordance with the
terms of the Warrants but prior to the delivery of the Warrant Shares, the Company shall, at the election of the Holder, which
shall be given within five (5) days of receipt of such notice of the Restrictive Legend Event, either (A) rescind the previously
submitted Election to Purchase and the Company shall return all consideration paid by registered holder for such shares upon such
rescission or (B) treat the attempted exercise as a cashless exercise as described in paragraph (ii) below and refund the cash
portion of the exercise price to the Holder.

 

(ii) If a Restrictive Legend Event has
occurred, the Warrant shall only be exercisable on a cashless basis. Notwithstanding anything herein to the contrary, the Company
shall not be required to make any cash payments or net cash settlement to the Holder in lieu of delivery of the Warrant Shares.
Upon a “cashless exercise”, the Holder shall be entitled to receive the number of Warrant Shares equal to the quotient
obtained by dividing (A-B) (X) by (A), where:

 

		(A)	=
the VWAP on the Trading Day immediately preceding the Exercise Date;

 

	 	(B)	= the Exercise Price of the Warrant, as adjusted as set forth herein; and

 

	 	(X)	= the number of Warrant Shares that would be issuable upon exercise of the Warrant in accordance with the terms of the Warrant if such exercise were by means of a cash exercise rather than a cashless exercise.

 

If the Warrant Shares are issued in such
a cashless exercise, the Company acknowledges and agrees that, in accordance with Section 3(a)(9) of the Securities Act, the Warrant
Shares shall take on the registered characteristics of the Warrants being exercised and the Company agrees not to take any position
contrary thereto. Upon receipt of an Election to Purchase for a cashless exercise, the Warrant Agent will promptly deliver a copy
of the Election to Purchase to the Company to confirm the number of Warrant Shares issuable in connection with the cashless exercise.
The Company shall calculate and transmit to the Warrant Agent in a written notice, and the Warrant Agent shall have no duty, responsibility
or obligation under this section to calculate, the number of Warrant Shares issuable in connection with any cashless exercise.
The Warrant Agent shall be entitled to rely conclusively on any such written notice provided by the Company, and the Warrant Agent
shall not be liable for any action taken, suffered or omitted to be taken by it in accordance with such written instructions or
pursuant to this Warrant Agreement.

  

     

     

    

 

3.3.8 Disputes. In the case
of a dispute as to the determination of the Exercise Price or the arithmetic calculation of the number of Warrant Shares issuable
in connection with any exercise, the Company shall promptly deliver to the Holder the number of Warrant Shares that are not disputed.

 

3.3.9 [Reserved.]

 

3.3.10 Beneficial Ownership Limitation.
A Holder shall not have the right to exercise any Warrants to the extent that after giving effect to the issuance of Warrant Shares
after exercise as set forth on the applicable Election to Purchase, such Holder or a person holding through such Holder (together
with such Holder’s or person’s Affiliates (as defined in Rule 405 under the Securities Act), and any other persons
acting as a group together with that Holder or person or any of that Holder’s or person’s Affiliates), would beneficially
own in excess of 4.99% (“Beneficial Ownership Limitation”) of the Company’s Common Stock. For purposes
of the foregoing sentence, the number of shares of Common Stock beneficially owned by a person shall include the number of Warrant
Shares that would be owned by that person issuable upon exercise of the Warrants with respect to which such determination is being
made, but shall exclude the number of shares of Common Stock (i) which would be issuable upon exercise of the remaining, non-exercised
Warrants beneficially owned by that person or any of its Affiliates and (ii) underlying any other securities of the Company held
by such Holder or its Affiliates that are exercisable or convertible into Common Stock and subject to a limitation on conversion
or exercise that is analogous to the limitation contained in this Section 3.3.10. Except as set forth in the preceding sentence,
for purposes of this Section 3.3.10, beneficial ownership shall be calculated in accordance with Section 13(d) of the Securities
Exchange Act of 1934, as amended (the “Exchange Act”) and the rules and regulations promulgated thereunder,
it being acknowledged by the Holder that neither the Warrant Agent nor the Company is representing to the Holder that such calculation
is in compliance with Section 13(d) of the Exchange Act and the Holder or beneficial owner is solely responsible for any schedules
required to be filed in accordance therewith. To the extent that the limitation contained in this Section 3.3.10 applies, the determination
of whether a Warrant is exercisable and of the number of Warrants that are exercisable shall be in the sole discretion of the Holder,
and the submission of an Election to Purchase shall be deemed to be the Holder’s determination of whether such Warrant is
exercisable and of the number of Warrants that are exercisable, and neither the Warrant Agent nor the Company shall have any obligation
to verify or confirm the accuracy of such determination and neither of them shall have any liability for any error made by the
Holder or any other person. In addition, a determination as to any group status as contemplated above shall be determined in accordance
with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section 3.3.10,
in determining the number of outstanding shares of Common Stock, a Holder or other person may rely on the number of outstanding
shares of Common Stock as reflected in (A) the Company’s most recent periodic or annual report filed with the Securities
and Exchange Commission, as the case may be, (B) a more recent public announcement by the Company or (C) a more recent written
notice by the Company or the Company’s transfer agent setting forth the number of shares of Common Stock outstanding. For
any reason at any time, upon the written or oral request of a person that represents that it is or is acting on behalf of a Holder,
the Company shall, within two (2) Trading Days, confirm orally or in writing or by e-mail to that person the number of shares of
Common Stock then outstanding. Upon delivery of a written notice to the Company, the Holder may from time to time increase or decrease
the Beneficial Ownership Limitation to any other percentage not in excess of 9.99% as specified in such notice, provided that any
increase in the Beneficial Ownership Limitation will not be effective until the sixty-first (61st) day after such notice
is delivered to the Company and any such increase or decrease will apply only to the Holder and its Affiliates and not to any other
holder of Warrants. The provisions of this Section 3.3.10 shall be construed and implemented in a manner otherwise than in strict
conformity with the terms of this Section 3.3.10 to correct this subsection (or any portion hereof) which may be defective or inconsistent
with the intended beneficial ownership limitation herein contained.

 

     

     

    

 

4. Adjustments.

 

4.1 Adjustment upon Subdivisions
or Combinations. If the Company at any time after the Issuance Date subdivides (by any stock split, stock dividend, recapitalization,
reorganization, scheme, arrangement or otherwise) its outstanding shares of Common Stock into a greater number of shares, the Exercise
Price in effect immediately prior to such subdivision will be proportionately reduced and the number of Warrant Shares will be
proportionately increased. If the Company at any time after the Issuance Date combines (by any stock split, stock dividend, recapitalization,
reorganization, scheme, arrangement or otherwise) its outstanding shares of Common Stock into a smaller number of shares, the Exercise
Price in effect immediately prior to such combination will be proportionately increased and the number of Warrant Shares will be
proportionately decreased. Any adjustment under this Section 4.1 shall become effective at the close of business on the date the
subdivision or combination becomes effective. The Company shall promptly notify Warrant Agent of any such adjustment and give specific
instructions to Warrant Agent with respect to any adjustments to the warrant register.

 

4.2 Adjustment for Other Distributions. In
the event the Company shall fix a record date for the making of a dividend or distribution to all holders of Common Stock of any
evidences of indebtedness or assets or subscription rights, options or warrants (excluding those referred to in Section 4.1 or
other dividends paid out of retained earnings), then in each such case the Holder will, upon the exercise of Warrants, be entitled
to receive, in addition to the number of Warrant Shares issuable thereupon, and without payment of any additional consideration
therefor, the amount of such dividend or distribution, as applicable, which such Holder would have held on the date of such exercise
had such Holder been the holder of record of such Warrant Shares as of the date on which holders of Common Stock became entitled
to receive such dividend or distribution. Such adjustment shall be made whenever any such distribution is made and shall become
effective immediately after the record date mentioned above.

 

4.3. Reclassification, Consolidation,
Purchase, Combination, Sale or Conveyance. If, at any time while the Warrants are outstanding, (i) the Company, directly or
indirectly, in one or more related transactions effects any merger or consolidation of the Company with or into another person,
(ii) the Company, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition
of all or substantially all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer,
tender offer or exchange offer (whether by the Company or another person) is completed pursuant to which holders of Common Stock
are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders
of 50% or more of the outstanding Common Stock (not including any Common Stock held by the other person or other persons making
or party to, or associated or affiliated with the other persons making, such purchase offer, tender offer or exchange offer), (iv)
the Company, directly or indirectly, in one or more related transactions effects any reclassification, reorganization or recapitalization
of the Common Stock or any compulsory share exchange pursuant to which the Common Stock is effectively converted into or exchanged
for other securities, cash or property, or (v) the Company, directly or indirectly, in one or more related transactions consummates
a stock or share purchase agreement or other business combination (including, without limitation, a reorganization, recapitalization,
spin-off or scheme of arrangement) with another person whereby such other person acquires more than 50% of the outstanding shares
of Common Stock (not including any shares of Common Stock held by the other person or other persons making or party to, or associated
or affiliated with the other persons making or party to, such stock or share purchase agreement or other business combination)
(each a “Fundamental Transaction”), then, upon any subsequent exercise of a Warrant, each Holder shall have
the right to receive, for each Warrant Share that would have been issuable upon such exercise immediately prior to the occurrence
of such Fundamental Transaction (without regard to any limitation in Section 3.3.10 on the exercise of the Warrants), the same
amount and kind of securities, cash or property, if any, of the successor or acquiring corporation or of the Company, if it is
the surviving corporation, and any additional consideration (the “Alternate Consideration”) receivable as a
result of such Fundamental Transaction by a holder of the number of shares of Common Stock for which each Warrant is exercisable
immediately prior to such Fundamental Transaction (without regard to any limitation in Section 3.3.10 on the exercise of the Warrants).
For purposes of any such exercise, the determination of the Exercise Price shall be appropriately adjusted to apply to such Alternate
Consideration based on the amount of Alternate Consideration issuable in respect of one share of Common Stock in such Fundamental
Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in a reasonable manner reflecting
the relative value of any different components of the Alternate Consideration. If holders of Common Stock are given any choice
as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder shall be given the same choice
as to the Alternate Consideration that such Holder receives upon any exercise of each Warrant following such Fundamental Transaction.
The Company shall cause any successor entity in a Fundamental Transaction in which the Company is not the survivor (the “Successor
Entity”) and for which stockholders received any equity securities of the Successor Entity and for which stockholders
received any equity securities of the Successor Entity, to assume in writing all of the obligations of the Company under this Warrant
Agreement in accordance with the provisions of this Section 4.3 pursuant to written agreements and shall, upon the written request
of such Holder, deliver to such Holder in exchange for the applicable Warrants created by this Warrant Agreement a security of
the Successor Entity evidenced by a written instrument substantially similar in form and substance to the Warrants which are exercisable
for a corresponding number of shares of capital stock of such Successor Entity (or its parent entity), if any, plus any Alternate
Consideration, receivable as a result of such Fundamental Transaction by a holder of the number of shares of Common Stock for which
the Warrants are exercisable immediately prior to such Fundamental Transaction, and with an exercise price which applies the Exercise
Price hereunder to such shares of capital stock, if any, plus any Alternate Consideration (but taking into account the relative
value of the shares of Common Stock pursuant to such Fundamental Transaction and the value of such shares of capital stock plus
Alternative consideration after that Fundamental Transaction for the purpose of protecting the economic value of such Warrant immediately
prior to the consummation of such Fundamental Transaction). Upon the occurrence of any such Fundamental Transaction the Successor
Entity shall succeed to, and be substituted for (so that from and after the date of such Fundamental Transaction, the provisions
of this Warrant Agreement and the Warrants referring to the “Company” shall refer instead to the Successor Entity),
and may exercise every right and power of the Company and shall assume all of the obligations of the Company under this Warrant
Agreement and the Warrants with the same effect as if such Successor Entity had been named as the Company herein and therein.

 

     

     

    

 

The Company shall instruct the Warrant
Agent in writing to mail by first class mail, postage prepaid, to each Holder, written notice of the execution of any such amendment,
supplement or agreement with the Successor Entity. Any supplemented or amended agreement entered into by the successor corporation
or transferee shall provide for adjustments, which shall be as nearly equivalent as may be practicable to the adjustments provided
for in this Section 4.3. The Warrant Agent shall have no duty, responsibility or obligation to determine the correctness of any
provisions contained in such agreement or such notice, including but not limited to any provisions relating either to the kind
or amount of securities or other property receivable upon exercise of warrants or with respect to the method employed and provided
therein for any adjustments, and shall be entitled to rely conclusively for all purposes upon the provisions contained in any such
agreement. The provisions of this Section 4.3 shall similarly apply to successive reclassifications, changes, consolidations, mergers,
sales and conveyances of the kind described above.

 

4.4. [RESERVED].

 

4.5 Other Events. If any event
occurs of the type contemplated by the provisions of Section 4.1 or 4.2 but not expressly provided for by such provisions (including,
without limitation, the granting of stock appreciation rights, Adjustment Rights, phantom stock rights or other rights with equity
features to all holders of Common Stock for no consideration), then the Company's Board of Directors will, at its discretion and
in good faith, make an adjustment in the Exercise Price and the number of Warrant Shares or designate such additional consideration
to be deemed issuable upon exercise of a Warrant, so as to protect the rights of the registered Holder. No adjustment to the Exercise
Price will be made pursuant to more than one sub-section of this Section 4 in connection with a single issuance.

 

     

     

    

 

4.6. Notices of Changes in Warrant.
Upon every adjustment of the Exercise Price or the number of Warrant Shares issuable upon exercise of a Warrant, the Company shall
give written notice thereof to the Warrant Agent, which notice shall state the Exercise Price resulting from such adjustment and
the increase or decrease, if any, in the number of Warrant Shares purchasable at such price upon the exercise of a Warrant, setting
forth in reasonable detail the method of calculation and the facts upon which such calculation is based. Upon the occurrence of
any event specified in Sections 4.1 or 4.2, then, in any such event, the Company shall give written notice to each Holder, at the
last address set forth for such holder in the Warrant Register, as of the record date or the effective date of the event. Failure
to give such notice, or any defect therein, shall not affect the legality or validity of such event. The Warrant Agent shall be
entitled to rely conclusively on, and shall be fully protected in relying on, any certificate, notice or instructions provided
by the Company with respect to any adjustment of the Exercise Price or the number of shares issuable upon exercise of a Warrant,
or any related matter, and the Warrant Agent shall not be liable for any action taken, suffered or omitted to be taken by it in
accordance with any such certificate, notice or instructions or pursuant to this Warrant Agreement. The Warrant Agent shall not
be deemed to have knowledge of any such adjustment unless and until it shall have received written notice thereof from the Company.

 

5. Restrictive Legends; Fractional
Warrants.

 

In the event that a Warrant Certificate
surrendered for transfer bears a restrictive legend, the Warrant Agent shall not register that transfer until the Warrant Agent
has received an opinion of counsel for the Company stating that such transfer may be made and indicating whether the Warrants must
also bear a restrictive legend upon that transfer. The Warrant Agent shall not be required to effect any registration of transfer
or exchange which will result in the transfer of or delivery of a Warrant Certificate for a fraction of a Warrant.

 

 6. [RESERVED].

 

7. Other Provisions Relating to
Rights of Holders of Warrants.

 

7.1. No Rights as Stockholder.
Except as otherwise specifically provided herein, a Holder, solely in its capacity as a holder of Warrants, shall not be entitled
to vote or receive dividends or be deemed the holder of share capital of the Company for any purpose, nor shall anything contained
in this Warrant Agreement be construed to confer upon a Holder, solely in its capacity as the registered holder of Warrants, any
of the rights of a stockholder of the Company or any right to vote, give or withhold consent to any corporate action (whether any
reorganization, issue of stock, reclassification of share capital, consolidation, merger, conveyance or otherwise), receive notice
of meetings, receive dividends or subscription rights or rights to participate in new issues of shares, or otherwise, prior to
the issuance to the Holder of the Warrant Shares which it is then entitled to receive upon the due exercise of Warrants.

 

7.2. Reservation of Common Stock.
The Company shall at all times reserve and keep available a number of its authorized but unissued shares of Common Stock that will
be sufficient to permit the exercise in full of all outstanding Warrants issued pursuant to this Warrant Agreement.

 

8. Concerning the Warrant Agent
and Other Matters.

 

8.1. Any instructions given to the Warrant
Agent orally, as permitted by any provision of this Warrant Agreement, shall be confirmed in writing by the Company as soon as
practicable. The Warrant Agent shall not be liable or responsible and shall be fully authorized and protected for acting, or failing
to act, in accordance with any oral instructions which do not conform with the written confirmation received in accordance with
this Section 8.1.

 

8.2. (a) Whether or not any Warrants are
exercised, for the Warrant Agent’s services as agent for the Company hereunder, the Company shall pay to the Warrant Agent
such fees as may be separately agreed between the Company and Warrant Agent and the Warrant Agent’s out of pocket expenses
in connection with this Warrant Agreement, including, without limitation, the fees and expenses of the Warrant Agent’s counsel.
While the Warrant Agent endeavors to maintain out-of-pocket charges (both internal and external) at competitive rates, these charges
may not reflect actual out-of-pocket costs, and may include handling charges to cover internal processing and use of the Warrant
Agent’s billing systems.

 

     

     

    

 

(b) All amounts owed
by the Company to the Warrant Agent under this Warrant Agreement are due within 30 days of the invoice date. Delinquent payments
are subject to a late payment charge of one and one-half percent (1.5%) per month commencing 45 days from the invoice date. The
Company agrees to reimburse the Warrant Agent for any attorney’s fees and any other costs associated with collecting delinquent
payments.

 

(c) No provision of
this Warrant Agreement shall require Warrant Agent to expend or risk its own funds or otherwise incur any financial liability in
the performance of any of its duties under this Warrant Agreement or in the exercise of its rights.

 

8.3 As agent for the Company hereunder
the Warrant Agent:

 

(a) shall have no duties
or obligations other than those specifically set forth herein or as may subsequently be agreed to in writing by the Warrant Agent
and the Company;

 

(b) shall be regarded
as making no representations and having no responsibilities as to the validity, sufficiency, value, or genuineness of the Warrants
or any Warrant Shares;

 

(c) shall not be obligated
to take any legal action hereunder; if, however, the Warrant Agent determines to take any legal action hereunder, and where the
taking of such action might, in its judgment, subject or expose it to any expense or liability it shall not be required to act
unless it has been furnished with an indemnity reasonably satisfactory to it;

  

(d) may rely on and
shall be fully authorized and protected in acting or failing to act upon any certificate, instrument, opinion, notice, letter,
telegram, telex, facsimile transmission or other document or security delivered to the Warrant Agent and believed by it to be genuine
and to have been signed by the proper party or parties;

  

(e) shall not be liable
or responsible for any recital or statement contained in the Registration Statement or any other documents relating thereto;

 

(f) shall not be liable
or responsible for any failure on the part of the Company to comply with any of its covenants and obligations relating to the Warrants,
including without limitation obligations under applicable securities laws;

 

(g) may rely on and
shall be fully authorized and protected in acting or failing to act upon the written, telephonic or oral instructions with respect
to any matter relating to its duties as Warrant Agent covered by this Warrant Agreement (or supplementing or qualifying any such
actions) of officers of the Company, and is hereby authorized and directed to accept instructions with respect to the performance
of its duties hereunder from the Company or counsel to the Company, and may apply to the Company, for advice or instructions in
connection with the Warrant Agent’s duties hereunder, and the Warrant Agent shall not be liable for any delay in acting while
waiting for those instructions; any applications by the Warrant Agent for written instructions from the Company may, at the option
of the Agent, set forth in writing any action proposed to be taken or omitted by the Warrant Agent under this Warrant Agreement
and the date on or after which such action shall be taken or such omission shall be effective; the Warrant Agent shall not be liable
for any action taken by, or omission of, the Warrant Agent in accordance with a proposal included in such application on or after
the date specified in such application (which date shall not be less than five business days after the date such application is
sent to the Company, unless the Company shall have consented in writing to any earlier date) unless prior to taking any such action,
the Warrant Agent shall have received written instructions in response to such application specifying the action to be taken or
omitted;

 

     

     

    

 

 

(h) may consult with
counsel satisfactory to the Warrant Agent, including its in-house counsel, and the advice of such counsel shall be full and complete
authorization and protection in respect of any action taken, suffered, or omitted by it hereunder in good faith and in accordance
with the advice of such counsel;

 

(i) may perform any
of its duties hereunder either directly or by or through nominees, correspondents, designees, or subagents, and it shall not be
liable or responsible for any misconduct or negligence on the part of any nominee, correspondent, designee, or subagent appointed
with reasonable care by it in connection with this Warrant Agreement;

 

(j) is not authorized,
and shall have no obligation, to pay any brokers, dealers, or soliciting fees to any person and

 

(k) shall not be required
hereunder to comply with the laws or regulations of any country other than the United States of America or any political subdivision
thereof.

 

8.4. (a) In the absence of gross negligence
or willful or illegal misconduct on its part, the Warrant Agent shall not be liable for any action taken, suffered, or omitted
by it or for any error of judgment made by it in the performance of its duties under this Warrant Agreement. Anything in this Warrant
Agreement to the contrary notwithstanding, in no event shall Warrant Agent be liable for special, indirect, incidental, consequential
or punitive losses or damages of any kind whatsoever (including but not limited to lost profits), even if the Warrant Agent has
been advised of the possibility of such losses or damages and regardless of the form of action. Any liability of the Warrant Agent
will be limited in the aggregate to the amount of fees paid by the Company hereunder. The Warrant Agent shall not be liable for
any failures, delays or losses, arising directly or indirectly out of conditions beyond its reasonable control including, but not
limited to, acts of government, exchange or market ruling, suspension of trading, work stoppages or labor disputes, fires, civil
disobedience, riots, rebellions, storms, electrical or mechanical failure, computer hardware or software failure, communications
facilities failures including telephone failure, war, terrorism, insurrection, earthquakes, floods, acts of God or similar occurrences.

 

(b) In the event any
question or dispute arises with respect to the proper interpretation of the Warrants or the Warrant Agent’s duties under
this Warrant Agreement or the rights of the Company or of any Holder, the Warrant Agent shall not be required to act and shall
not be held liable or responsible for its refusal to act until the question or dispute has been judicially settled (and, if appropriate,
it may file a suit in interpleader or for a declaratory judgment for such purpose) by final judgment rendered by a court of competent
jurisdiction, binding on all persons interested in the matter which is no longer subject to review or appeal, or settled by a written
document in form and substance satisfactory to Warrant Agent and executed by the Company and each such Holder. In addition, the
Warrant Agent may require for such purpose, but shall not be obligated to require, the execution of such written settlement by
all the Holders and all other persons that may have an interest in the settlement.

  

8.5. The Company covenants to indemnify
the Warrant Agent and hold it harmless from and against any loss, liability, claim or expense (“Loss”) arising
out of or in connection with the Warrant Agent’s duties under this Warrant Agreement, including the costs and expenses of
defending itself against any Loss, unless such Loss shall have been determined by a court of competent jurisdiction to be a result
of the Warrant Agent’s gross negligence or willful misconduct.

 

8.6. Unless terminated earlier by the parties
hereto, this Agreement shall terminate 90 days after the earlier of the Expiration Date and the date on which no Warrants remain
outstanding (the “Termination Date”). On the business day following the Termination Date, the Agent shall deliver
to the Company any entitlements, if any, held by the Warrant Agent under this Warrant Agreement. The Agent’s right to be
reimbursed for fees, charges and out-of-pocket expenses as provided in this Section 8 shall survive the termination of this Warrant
Agreement.

 

    	 	 	 

     

    

 

8.7. If any provision of this Warrant Agreement
shall be held illegal, invalid, or unenforceable by any court, this Warrant Agreement shall be construed and enforced as if such
provision had not been contained herein and shall be deemed an Agreement among the parties to it to the full extent permitted by
applicable law.

 

8.8. The Company represents and warrants
that (a) it is duly incorporated and validly existing under the laws of its jurisdiction of incorporation, (b) the offer and sale
of the Warrants and the execution, delivery and performance of all transactions contemplated thereby (including this Warrant Agreement)
have been duly authorized by all necessary corporate action and will not result in a breach of or constitute a default under the
articles of association, bylaws or any similar document of the Company or any indenture, agreement or instrument to which it is
a party or is bound, (c) this Warrant Agreement has been duly executed and delivered by the Company and constitutes the legal,
valid, binding and enforceable obligation of the Company, (d) the Warrants will comply in all material respects with all applicable
requirements of law and (e) to the best of its knowledge, there is no litigation pending or threatened as of the date hereof in
connection with the offering of the Warrants.

 

8.9. In the event of inconsistency between
this Warrant Agreement and the descriptions in the Registration Statement, as they may from time to time be amended, the terms
of this Warrant Agreement shall control.

 

8.10. Set forth in Annex C hereto
is a list of the names and specimen signatures of the persons authorized to act for the Company under this Warrant Agreement (the
“Authorized Representatives”). The Company shall, from time to time, certify to you the names and signatures
of any other persons authorized to act for the Company under this Warrant Agreement.

 

8.11. Except as expressly set forth elsewhere
in this Warrant Agreement, all notices, instructions and communications under this Agreement shall be in writing, shall be effective
upon receipt and shall be addressed, if to the Company, to its address set forth beneath its signature to this Agreement, or, if
to the Warrant Agent, to VStock Transfer, LLC 18 Lafayette Place, Woodmere, New York 11598, or to such other address of which
a party hereto has notified the other party.

 

8.12. (a) This Warrant Agreement shall
be governed by and construed in accordance with the laws of the State of New York. All actions and proceedings relating to or arising
from, directly or indirectly, this Warrant Agreement may be litigated in courts located within the Borough of Manhattan in the
City and State of New York. The Company hereby submits to the personal jurisdiction of such courts and consents that any service
of process may be made by certified or registered mail, return receipt requested, directed to the Company at its address last specified
for notices hereunder. Each of the parties hereto hereby waives the right to a trial by jury in any action or proceeding arising
out of or relating to this Warrant Agreement.

 

(b) This Warrant Agreement
shall inure to the benefit of and be binding upon the successors and assigns of the parties hereto. This Warrant Agreement may
not be assigned, or otherwise transferred, in whole or in part, by either party without the prior written consent of the other
party, which the other party will not unreasonably withhold, condition or delay; except that (i) consent is not required for an
assignment or delegation of duties by Warrant Agent to any affiliate of Warrant Agent and (ii) any reorganization, merger, consolidation,
sale of assets or other form of business combination by Warrant Agent or the Company shall not be deemed to constitute an assignment
of this Warrant Agreement.

 

(c) No provision of
this Warrant Agreement may be amended, modified or waived, except in a written document signed by both parties. The Company and
the Warrant Agent may amend or supplement this Warrant Agreement without the consent of any Holder for the purpose of curing any
ambiguity, or curing, correcting or supplementing any defective provision contained herein or adding or changing any other provisions
with respect to matters or questions arising under this Agreement as the parties may deem necessary or desirable and that the parties
determine, in good faith, shall not adversely affect the interest of the Holders.  All other amendments and supplements
shall require the vote or written consent of Holders of at least 50.1% of the then outstanding Warrants, provided that adjustments
may be made to the Warrant terms and rights in accordance with Section 4 without the consent of the Holders.

 

    	 	 	 

     

    

 

8.13 Payment of Taxes. The
Company will from time to time promptly pay all taxes and charges that may be imposed upon the Company or the Warrant Agent in
respect of the issuance or delivery of Warrant Shares upon the exercise of Warrants, but the Company may require the Holders to
pay any transfer taxes in respect of the Warrants or such shares. The Warrant Agent may refrain from registering any transfer of
Warrants or any delivery of any Warrant Shares unless or until the persons requesting the registration or issuance shall have paid
to the Warrant Agent for the account of the Company the amount of such tax or charge, if any, or shall have established to the
reasonable satisfaction of the Company and the Warrant Agent that such tax or charge, if any, has been paid. 

  

8.14 Resignation of Warrant Agent.

 

8.14.1. Appointment of Successor
Warrant Agent. The Warrant Agent, or any successor to it hereafter appointed, may resign its duties and be discharged from
all further duties and liabilities hereunder after giving thirty (30) days’ notice in writing to the Company, or such shorter
period of time agreed to by the Company. The Company may terminate the services of the Warrant Agent, or any successor Warrant
Agent, after giving thirty (30) days’ notice in writing to the Warrant Agent or successor Warrant Agent, or such shorter
period of time as agreed. If the office of the Warrant Agent becomes vacant by resignation, termination or incapacity to act or
otherwise, the Company shall appoint in writing a successor Warrant Agent in place of the Warrant Agent. If the Company shall fail
to make such appointment within a period of 30 days after it has been notified in writing of such resignation or incapacity by
the Warrant Agent, then the Warrant Agent or any Holder may apply to any court of competent jurisdiction for the appointment of
a successor Warrant Agent at the Company’s cost. Pending appointment of a successor to such Warrant Agent, either by the
Company or by such a court, the duties of the Warrant Agent shall be carried out by the Company. Any successor Warrant Agent (but
not including the initial Warrant Agent), whether appointed by the Company or by such court, shall be a person organized and existing
under the laws of any state of the United States of America, in good standing, and authorized under such laws to exercise corporate
trust powers and subject to supervision or examination by federal or state authority. After appointment, any successor Warrant
Agent shall be vested with all the authority, powers, rights, immunities, duties, and obligations of its predecessor Warrant Agent
with like effect as if originally named as Warrant Agent hereunder, without any further act or deed, and except for executing and
delivering documents as provided in the sentence that follows, the predecessor Warrant Agent shall have no further duties, obligations,
responsibilities or liabilities hereunder, but shall be entitled to all rights that survive the termination of this Warrant Agreement
and the resignation or removal of the Warrant Agent, including but not limited to its right to indemnity hereunder. If for any
reason it becomes necessary or appropriate or at the request of the Company, the predecessor Warrant Agent shall execute and deliver,
at the expense of the Company, an instrument transferring to such successor Warrant Agent all the authority, powers, and rights
of such predecessor Warrant Agent hereunder; and upon request of any successor Warrant Agent the Company shall make, execute, acknowledge,
and deliver any and all instruments in writing for more fully and effectually vesting in and confirming to such successor Warrant
Agent all such authority, powers, rights, immunities, duties, and obligations.

 

8.14.2. Notice of Successor Warrant
Agent. In the event a successor Warrant Agent shall be appointed, the Company shall give notice thereof to the predecessor
Warrant Agent and the transfer agent for the Common Stock not later than the effective date of any such appointment.

 

8.14.3. Merger or Consolidation
of Warrant Agent. Any person into which the Warrant Agent may be merged or converted or with which it may be consolidated or
any person resulting from any merger, conversion or consolidation to which the Warrant Agent shall be a party or any person succeeding
to the shareowner services business of the Warrant Agent or any successor Warrant Agent shall be the successor Warrant Agent under
this Warrant Agreement, without any further act or deed. For purposes of this Warrant Agreement, “person” shall mean
any individual, firm, corporation, partnership, limited liability company, joint venture, association, trust or other entity, and
shall include any successor (by merger or otherwise) thereof or thereto.

 

    	 	 	 

     

    

 

9. Miscellaneous Provisions.

 

9.1. Persons Having Rights under
this Warrant Agreement. Nothing in this Warrant Agreement expressed and nothing that may be implied from any of the provisions
hereof is intended, or shall be construed, to confer upon, or give to, any person or corporation other than the parties hereto
and the Holders any right, remedy, or claim under or by reason of this Warrant Agreement or of any covenant, condition, stipulation,
promise, or agreement hereof.

 

9.2. Examination of the Warrant
Agreement. A copy of this Warrant Agreement shall be available at all reasonable times at the office of the Warrant Agent designated
for such purpose for inspection by any Holder. Prior to such inspection, the Warrant Agent may require any such holder to provide
reasonable evidence of its interest in the Warrants.

 

9.3. Counterparts. This Warrant
Agreement may be executed in any number of original, facsimile or electronic counterparts and each of such counterparts shall for
all purposes be deemed to be an original, and all such counterparts shall together constitute but one and the same instrument.

 

9.4. Effect of Headings. The
Section headings herein are for convenience only and are not part of this Warrant Agreement and shall not affect the interpretation
thereof.

 

10. Certain Definitions.

 

As used herein, the following terms shall
have the following meanings:

 

(i) “Adjustment Right”
means any right granted with respect to any securities issued in connection with, or with respect to, any issuance, sale or delivery
(or deemed issuance, sale or delivery in accordance with Section 4) of Common Stock (other than rights of the type described in
Section 4.2 and 4.3 hereof) that could result in a decrease in the net consideration received by the Company in connection with,
or with respect to, such securities (including, without limitation, any cash settlement rights, cash adjustment or other similar
rights) but excluding anti-dilution and other similar rights (including pursuant to Section 4.4 of this Agreement).

 

(ii) “Approved Stock Plan”
means any employee benefit plan which has been approved by the board of directors of the Company prior to or subsequent to the
date hereof pursuant to which Common Stock and options to purchase Common Stock may be issued to any employee, consultant, officer
or director or other service provider for services provided to the Company in their capacity as such.

 

(iii) “Convertible Securities”
means any notes, rights, warrants or other securities (other than Options) that are at any time and under any circumstances, directly
or indirectly, convertible into, exercisable or exchangeable for, or which otherwise entitles the holder thereof to acquire, shares
of Common Stock.

 

    	 	 	 

     

    

 

(iv). “Excluded Securities”
means (1) Common Stock or options or other rights to purchase Common Stock or other awards issued to directors, officers, employees,
consultants or other service providers of the Company in their capacity as such pursuant to an Approved Stock Plan, provided that
(A) all such issuances (taking into account the Common Stock issuable upon exercise of such options) after the date hereof pursuant
to this clause (i) do not, in the aggregate, exceed more than 30% of the Common Stock issued and outstanding immediately prior
to the date hereof; provided however, that such issuances to consultants or other service providers do not, in each instance in
the aggregate, exceed more than 5% of the Common Stock issued and outstanding immediately prior to the date hereof, and (B) the
exercise price of any such options is not lowered, none of such options are amended to increase the number of shares issuable thereunder
in each case other than pursuant to the terms hereof (including any anti-dilution provisions contained therein) and none of the
terms or conditions of any such options are otherwise materially changed in any manner that adversely affects any of the holders
of Warrants; (2) Common Stock issued upon the conversion or exercise of Convertible Securities (other than options or other rights
to purchase Common Stock issued pursuant to an Approved Stock Plan that are covered by clause (i) above) issued prior to the date
hereof, provided that the conversion price of any such Convertible Securities (other than options or other rights to purchase Common
Stock issued pursuant to an Approved Stock Plan that are covered by clause (1) above) is not lowered through the amendment or waiver
of such Convertible Security, none of such Convertible Securities (other than options or other rights to purchase Common Stock
issued pursuant to an Approved Stock Plan that are covered by clause (1) above) are amended to increase the number of shares issuable
thereunder and none of the terms or conditions of any such Convertible Securities (other than options or other rights to purchase
Common Stock issued pursuant to an Approved Stock Plan that are covered by clause (1) above) are otherwise materially changed in
any manner that adversely affects any of the holders of Warrants; (3) Common Stock issuable upon exercise of the Warrants; and
(4) securities issuable in connection with strategic license agreements, other partnering arrangements or acquisitions or mergers
where the purchaser or acquirer of the securities in such issuance solely consists of (A) either (x) the actual participants in
such strategic license, strategic alliance, strategic partnership or other partnering arrangements, (y) the actual owners of such
assets or securities acquired in such acquisition or merger or (z) the stockholders, partners or members of the foregoing persons
or entities and (B) number or amount of securities issued to such person or entity by the Company shall not be disproportionate
(as determined in good faith by the Board of Directors of the Company) to either (x) the fair market value of such person’s
or entity’s actual contribution to such strategic alliance or strategic partnership or (y) the proportional ownership of
such assets or securities to be acquired by the Company, as applicable; provided, that, notwithstanding the foregoing, such purchaser
or acquirer of the securities in such issuance shall not include any person regularly engaged in the business of buying or selling
securities.

 

(v) [RESERVED].

 

(vi) “New Issuance Price”
means a price (calculated to the nearest cent) determined in accordance with the following formula:

 

EP2 = EP1* (A
+ B) ÷ (A + C).

 

For purposes of the foregoing formula,
the following definitions shall apply:

 

	 	(a)	“EP2” shall mean the adjusted Exercise Price;

 

	 	(b)	“EP1” shall mean the Exercise Price in effect immediately prior to such issuance of Common Stock;

 

	 	(c)	“A” shall mean the number of shares of Common Stock outstanding immediately prior to such issue of additional Common Stock including the issuance, sale or delivery of Common Stock owned or held by or for the account of the Company, (treating for this purpose as outstanding all shares of Common Stock issuable upon exercise of Options outstanding immediately prior to such issue or upon conversion or exchange of Convertible Securities outstanding (assuming exercise of any outstanding Options therefor) immediately prior to such issue);  

 

	 	(d)	“B” shall mean the number of shares of Common Stock that would have been issued if such additional shares of Common Stock had been issued at an Exercise Price equal to EP1 (determined by dividing the aggregate consideration received by the Company in respect of such issue by EP1); and

 

	 	(e)	“C” shall mean the number of such additional shares of Common Stock issued in such transaction.

 

(vii) “Options” means
any rights, warrants or options to subscribe for or purchase Common Stock or Convertible Securities.

 

    	 	 	 

     

    

 

(viii) Reserved.

 

(ix) “Trading Day” means
any day on which the Common Stock is traded on the Trading Market, or, if the Trading Market is not the principal trading market
for the Common Stock, then on the principal securities exchange or securities market in the United States on which the the Common
Stock is then traded, provided that “Trading Day” shall not include any day on which the Common Stock is are scheduled
to trade on such exchange or market for less than 4.5 hours or any day that the Common Stock is suspended from trading during the
final hour of trading on such exchange or market (or if such exchange or market does not designate in advance the closing time
of trading on such exchange or market, then during the hour ending at 4:00 P.M., New York City time).

 

(x) “Trading Market”
means NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market or the New York Stock Exchange.

 

(xi) “VWAP” means, for
any date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed or quoted
on a Trading Market, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding date)
on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P. (based on a Trading Day
from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)), (b) the volume weighted average price of the Common Stock
for such date (or the nearest preceding date) on the OTC Bulletin Board, (c) if the Common Stock are not then listed or quoted
for trading on the OTC Bulletin Board and if prices for the Common Stock are then reported in the OTCQB maintained by OTC Markets
Group, Inc. (or a similar organization or agency succeeding to its functions of reporting prices), the most recent bid price per
share of Common Stock so reported, or (d) in all other cases, the fair market value of the Common Stock as determined by an independent
appraiser selected in good faith by the Company, the fees and expenses of which shall be paid by the Company.

  

IN WITNESS WHEREOF, this Warrant Agent
Agreement has been duly executed by the parties hereto as of the day and year first above written.

 

	 	AYTU BIOSCIENCE INC.
	 	 
	 	By:	 
	 	Name:
	 	Title:
	 	 
	 	Address for notices:
	 	Aytu Bioscience, Inc.
	 	373 Inverness Parkway, Suite 206
	 	Englewood, CA 80112
	 	Attention:
	 	Telephone:
	 	Facsimile:
	 	E-mail:
	 	 	 
	 	VStock Transfer, LLC
	 	As Warrant Agent
	 	 	 
	 	By:	 
	 	Name:
	 	Title:

 

Annex A Form of Warrant Certificates

Annex B Election to Purchase

Annex C Authorized Representatives

 

     

     

    

  

ANNEX A

 

[TO
BE INCLUDED IN THE GLOBAL CERTIFICATE]

 

[UNLESS
THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”),
TO ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME
OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO
CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE, OR OTHER
USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO.,
HAS AN INTEREST HEREIN.]

 

AYTU BIOSCIENCE INC.

WARRANT CERTIFICATE

NOT EXERCISABLE AFTER ______, 20__

 

This certifies that
the person whose name and address appears below, or registered assigns, is the registered owner of the number of Warrants set forth
below. Each Warrant entitles its registered holder to purchase from Aytu Bioscience Inc., a company incorporated under the laws
of the State of Delaware (the “Company”), at any time prior to 5:00 P.M. (New York City time) on ________, 20__,
one share of common stock, par value $0.0001 per share, of the Company (each, a “Warrant Share” and collectively,
the “Warrant Shares”), at an exercise price of $___ per share, subject to possible adjustments as provided in
the Warrant Agreement (as defined below).

 

This Warrant Certificate,
with or without other Warrant Certificates, upon surrender at the designated office of the Warrant Agent, may be exchanged for
another Warrant Certificate or Warrant Certificates evidencing the same number of Warrants as the Warrant Certificate or Warrant
Certificates surrendered. A transfer of the Warrants evidenced hereby may be registered upon surrender of this Warrant Certificate
at the designated office of the Warrant Agent by the registered holder in person or by a duly authorized attorney, properly endorsed
or accompanied by proper instruments of transfer, a signature guarantee, and such other and further documentation as the Warrant
Agent may reasonably request and duly stamped as may be required by the laws of the State of New York and of the United States
of America.

 

The terms and conditions
of the Warrants and the rights and obligations of the holder of this Warrant Certificate are set forth in the Warrant Agent Agreement
dated as of _______, 2016 (the “Warrant Agreement”) between the Company and VStock Transfer, LLC (the “Warrant
Agent”). A copy of the Warrant Agreement is available for inspection during business hours at the office of the Warrant
Agent.

 

This Warrant Certificate
shall not be valid or obligatory for any purpose until it shall have been countersigned by an authorized signatory of the Warrant
Agent.

 

WITNESS the facsimile signature of a proper
officer of the Company.

 

	 	AYTU BIOSCIENCE INC.
	 	 	 
	 	By:	 
	 	 	Name:
	 	 	Title:

 

     

     

    

 

	Dated: ______, 2016
	Countersigned:
	 
	VStock Transfer, LLC,
	as Warrant Agent

 

	By:	 	 
	Name:	 
	Title:	 

 

PLEASE DETACH HERE

——————————————————————————————————————

 

Certificate No.:_________ Number of Warrants:__________

 

WARRANT CUSIP NO.: ___________

  

	 	AYTU BIOSCIENCE INC.
	 	 
	[Name & Address of Holder]	_______________, Warrant

Agent
	 	 
	 	By mail:
	 	 
	 	_____________
	 	 
	 	By hand or overnight courier:
	 	 
	 	_____________

  

     

     

    

 

ANNEX B

 

[Form of Election to Purchase]

 

(To Be Executed Upon Exercise Of Warrants
not evidenced by a Global Certificate)

 

The undersigned hereby irrevocably elects
to exercise the right, represented by Warrants evidenced by this Warrant Certificate, to receive                 
Warrant Shares and herewith tenders payment for such Warrant Shares to the order of ___________, in the amount of $             
in accordance with the terms hereof.

 

OR

 

[In cases where cashless exercise is permitted
under the Warrant Agreement] — The undersigned hereby irrevocably elects to exercise the right, represented by Warrants evidenced
by this Warrant Certificate, to receive                Warrant
Shares (before giving effect to the cashless exercise provisions) and herewith agrees to make payment therefor pursuant to the
cashless exercise provisions of the Warrant Agreement, all on the terms and the conditions specified in the Warrant Agent Agreement.

 

The undersigned requests that a certificate
for such Warrant Shares be registered in the name of                     ,
whose address is                     
and that such certificate be delivered to                     ,
whose address is                                         .
If the number of Warrants being exercised hereby is less than all the Warrants evidenced by this Warrant Certificate, the undersigned
requests that a new Warrant Certificate representing the remaining unexercised Warrants be registered in the name of                                         ,
whose address is                                         ,
and that such Warrant Certificate be delivered to                whose
address is                                         .

 

	 	 	Signature
	 	 	 
	Date:	 	 
	 	 	 
	 	 	Signature Guaranteed

 

Signatures must be guaranteed by an “eligible guarantor
institution” meeting the requirements of the Warrant Agent, which requirements include membership or participation in the
Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may
be determined by the Warrant Agent in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange
Act of 1934, as amended.

 

     

     

    

  

ANNEX C

 

AUTHORIZED REPRESENTATIVES

 

	Name	 	Title	 	Signature
	Zvi Ben David	 	Chief Financial Officer	 	 
	Ronen Raviv	 	ControllerEX-10.1

 Exhibit 10.1 

Execution Version 
  

 
  

SECOND AMENDMENT TO 

CREDIT AGREEMENT 

dated as of October 19, 2016 

among 

RICE MIDSTREAM PARTNERS LP, 

as Parent Guarantor, 

RICE MIDSTREAM OPCO LLC, 

as Borrower, 
 The
Guarantors Party Hereto, 
 WELLS FARGO BANK, N.A., 

as Administrative Agent, 

and 
 The Lenders Party
Hereto 
 BARCLAYS BANK PLC, 

as Syndication Agent 

WELLS FARGO SECURITIES, LLC, 

and 

BARCLAYS BANK PLC, 

as Joint Lead Arrangers and Joint Bookrunners 
  

 
  

 SECOND AMENDMENT TO CREDIT
AGREEMENT 
 This SECOND AMENDMENT TO
CREDIT AGREEMENT (this “Second Amendment”), dated as of October 19, 2016 (the “Second Amendment Effective Date”), is among RICE MIDSTREAM
OPCO LLC, a Delaware limited liability company (the “Borrower”); RICE MIDSTREAM PARTNERS LP, a Delaware limited partnership, as a parent guarantor (the
“Parent”); each of the other undersigned guarantors (including the Vantage Midstream Entities (as defined below), the “Guarantors”, and together with the Parent and the Borrower, the “Credit
Parties”); each of the Lenders that is a signatory hereto; and WELLS FARGO BANK, N.A., as administrative agent for the Lenders (in such capacity, together with its successors in such capacity,
the “Administrative Agent”). 
 Recitals 

A. The Borrower, the Administrative Agent and the Lenders are parties to that certain Credit Agreement dated as of December 22, 2014 (as
amended or otherwise modified prior to the date hereof, the “Credit Agreement”), pursuant to which the Lenders have, subject to the terms and conditions set forth therein, made certain credit available to and on behalf of the
Borrower. 
 B. The Borrower has advised the Administrative Agent and the Lenders that (i) REI has entered into a Purchase and Sale
Agreement dated as of September 26, 2016 (the “Vantage Acquisition Agreement”) with Vantage Energy Investment LLC, Vantage Energy Investment II LLC, Vantage Energy, LLC and Vantage Energy II, LLC (all such parties to the
Vantage Acquisition Agreement other than REI, collectively, the “Vantage Parties”), pursuant to which REI and/or its subsidiaries will acquire the Company Interests (as defined in the Vantage Acquisition Agreement), (ii) the
Parent has entered into a Purchase and Sale Agreement dated as of September 26, 2016 (the “Midstream Dropdown Agreement”) with REI pursuant to which, contemporaneously with but immediately following REI’s direct or
indirect acquisition of the Company Interests described in the foregoing clause (i), REI will convey, or cause to be conveyed, to Rice Poseidon 100% of the outstanding Equity Interests in each of Vantage Energy II Access, LLC, a Delaware limited
liability company, and Vista Gathering, LLC, a Delaware limited liability company (such entities, collectively, the “Vantage Midstream Entities”, the Midstream Properties owned by the Vantage Midstream Entities, the “Vantage
Midstream Assets”, and the Borrower’s direct or indirect acquisition of the Equity Interests in the Vantage Midstream Entities and the Vantage Midstream Assets, the “Vantage Midstream Acquisition”), and (iii) upon
consummation of the Vantage Midstream Acquisition, each of the Vantage Midstream Entities will become Restricted Subsidiaries and Guarantors under the Credit Agreement. 

C. The parties hereto desire to amend certain terms of the Credit Agreement as set forth herein to, among other things, increase the aggregate
Commitments of the Lenders under the Credit Agreement from $450,000,000 to $850,000,000 in connection with the Vantage Midstream Acquisition. 

D. The Borrower has requested that Citizens Bank NA, JPMorgan Chase Bank, N.A., Deutsche Bank AG New York, The Huntington National Bank and
ABN AMRO Capital USA 

  
 Page 1 

 
LLC (each, a “New Lender” and, collectively, the “New Lenders”) become Lenders under the Credit Agreement with a Commitment in the amount as shown on Annex I to
the Credit Agreement (as amended hereby). 
 NOW, THEREFORE, in consideration of the premises and the mutual covenants herein contained, for
good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

Section 1. Defined Terms. Each capitalized term which is defined in the Credit Agreement, but which is not defined in this Second
Amendment, shall have the meaning ascribed such term in the Credit Agreement, as amended hereby. Unless otherwise indicated, all section references in this Second Amendment (including in the recitals hereto) refer to the Credit Agreement. 

Section 2. Amendments. In reliance on the representations, warranties, covenants and agreements contained in this Second
Amendment, and subject to the satisfaction of the conditions precedent set forth in Section 3 hereof, the Credit Agreement shall be amended effective as of the Second Amendment Effective Date in the manner provided in this
Section 2. 
 2.1 Additional Definitions. Section 1.02 of the Credit Agreement is hereby amended to add thereto in
alphabetical order the following definitions which shall read in full as follows: 
 “Bail-In Action” means
the exercise of any Write-Down and Conversion Powers by the applicable EEA Resolution Authority in respect of any liability of an EEA Financial Institution. 

“Bail-In Legislation” means, with respect to any EEA Member Country implementing Article 55 of Directive
2014/59/EU of the European Parliament and of the Council of the European Union, the implementing law for such EEA Member Country from time to time which is described in the EU Bail-In Legislation Schedule. 

“EEA Financial Institution” means (a) any credit institution or investment firm established in any EEA
Member Country which is subject to the supervision of an EEA Resolution Authority, (b) any entity established in an EEA Member Country which is a parent of an institution described in clause (a) of this definition, or (c) any
financial institution established in an EEA Member Country which is a subsidiary of an institution described in clauses (a) or (b) of this definition and is subject to consolidated supervision with its parent. 

“EEA Member Country” means any of the member states of the European Union, Iceland, Liechtenstein, and Norway.

 “EEA Resolution Authority” means any public administrative authority or any person entrusted with public
administrative authority of any EEA Member Country (including any delegee) having responsibility for the resolution of any EEA Financial Institution. 

  
 Page 2 

 “EU Bail-In Legislation Schedule” means the EU Bail-In
Legislation Schedule published by the Loan Market Association (or any successor person), as in effect from time to time. 

“Second Amendment” means that certain Second Amendment to Credit Agreement dated as of October 19, 2016
among the Parent, the Borrower, the other Guarantors party thereto, the Administrative Agent and the Lenders party thereto. 

“Second Amendment Effective Date” means October 19, 2016. 

“Vantage Midstream Acquisition” has the meaning given to such term in the Second Amendment. 

“Write-Down and Conversion Powers” means, with respect to any EEA Resolution Authority, the write-down and
conversion powers of such EEA Resolution Authority from time to time under the Bail-In Legislation for the applicable EEA Member Country, which write-down and conversion powers are described in the EU Bail-In Legislation Schedule. 

2.2 Amended Definitions. The following definitions contained in Section 1.02 of the Credit Agreement are hereby amended and
restated in their entirety to read in full as follows: 
 “Anti-Corruption Laws” means all state or federal
laws, rules, and regulations applicable to the Parent, the Borrower or any of their Affiliates from time to time concerning or relating to money-laundering, bribery or corruption, including the FCPA. 

“Applicable Margin” means, for any day, with respect to any ABR Loan or Eurodollar Loan, or with respect to
the Commitment Fee Rate, as the case may be, the rate per annum set forth in the grid below based upon the Consolidated Total Leverage Ratio, determined as provided below in this definition: 

 

															
	 Level
	  	 Consolidated Total Leverage
Ratio
	  	Eurodollar
Loans	 	 	ABR
Loans	 	 	Commitment
Fee Rate	 
	1	  	Less than 3.00 to 1.00	  	 	2.000	% 	 	 	1.000	% 	 	 	0.375	% 
	2	  	Greater than or equal to 3.00 to 1.00 but less than 3.50 to 1.00	  	 	2.250	% 	 	 	1.250	% 	 	 	0.375	% 
	3	  	Greater than or equal to 3.50 to 1.00 but less than 4.00 to 1.00	  	 	2.500	% 	 	 	1.500	% 	 	 	0.500	% 
	4	  	Greater than or equal to 4.00 but less than 4.50 to 1.00	  	 	2.750	% 	 	 	1.750	% 	 	 	0.500	% 
	5	  	Greater than or equal to 4.50 to 1.00	  	 	3.00	% 	 	 	2.00	% 	 	 	0.500	% 

  
 Page 3 

 For purposes of this definition, the Consolidated Total Leverage Ratio shall be
calculated quarterly, as of the last day of each fiscal quarter of the Borrower. Each change in the Applicable Margin resulting from a calculation of the Consolidated Total Leverage Ratio shall become effective on and after the date on which
financial statements for such fiscal quarter and a compliance certificate showing such calculation are delivered to the Lenders pursuant to Section 8.01(a), (b) or (c) and shall remain in effect until the next
such financial statements and compliance certificate are so delivered; provided, however, that (x) if at any time the Parent and the Borrower fail to deliver any financial statements or a compliance certificate required by
Section 8.01(a), (b) or (c), as applicable, then, for the period commencing on the date of such Default and ending on the date on which such Default is cured, the “Applicable Margin” means the rate per
annum set forth on the grid when the Consolidated Total Leverage Ratio is at level “5” in the grid set forth above and (y) subject to the foregoing clause (x), for the period commencing on the Second Amendment Effective Date and until
the date on which the financial statements and compliance certificate for the fiscal quarter ending on September 30, 2016 are delivered pursuant to Section 8.01(b) and (c), the “Applicable Margin” means the rate per
annum set forth on the grid when the Consolidated Total Leverage Ratio is at level “1” in the grid set forth above. In the event that any financial statement or compliance certificate delivered pursuant to Section 8.01(a),
(b) or (c) is shown to be inaccurate (regardless of whether this Agreement or the Commitments are in effect when such inaccuracy is discovered), and such inaccuracy, if corrected, would have led to the application of a higher
Applicable Margin for any period (an “Applicable Period”) than the Applicable Margin applied for such Applicable Period, and only in such case, then the Parent and the Borrower shall immediately (i) deliver to the
Administrative Agent a corrected compliance certificate for such Applicable Period, (ii) determine the Applicable Margin for such Applicable Period based upon the corrected compliance certificate, and (iii) immediately pay to the
Administrative Agent the accrued additional interest owing as a result of such increased Applicable Margin for such Applicable Period, which payment shall be promptly applied by the Administrative Agent in accordance with Section 4.01.
The preceding sentence is in addition to rights of the Administrative Agent and Lenders with respect to Sections 3.02(c), 10.01 and 10.02 and other of their respective rights under this Agreement. 

“Commitment” means, with respect to each Lender, the commitment of such Lender to make Loans and to acquire
participations in Letters of Credit hereunder, expressed as an amount representing the maximum aggregate amount of such Lender’s Revolving Credit Exposure hereunder, as such commitment may be modified from time to time pursuant to
Section 2.06 and modified from time to time pursuant to assignments by or to such Lender pursuant to Section 12.04(b). The initial amount of each Lender’s Commitment is set forth on Annex I hereto, in the
Assignment and Assumption pursuant to which such Lender shall have assumed its Commitment or in the Additional Lender Agreement pursuant to which any Additional Lender shall have provided any Additional Commitment, as applicable. The aggregate
amount of the Lenders’ Commitments on the Second Amendment Effective Date is $850,000,000. 

  
 Page 4 

 “Continuing Director” means, at any date, an individual
(a) who is a director of the General Partner on the Effective Date, (b) who, as of the date of determination, has been a director of the General Partner for at least the twelve preceding months, (c) who has been nominated to be a
director of the General Partner, directly or indirectly, by REI and/or its subsidiaries or Persons nominated by REI and/or its subsidiaries, (d) who is nominated, appointed or approved for consideration by shareholders for election by the board
of directors of the General Partner, or (e) who is appointed by directors so nominated, appointed or approved. 

“Federal Funds Effective Rate” means, for any day, the weighted average of the rates on overnight Federal
funds transactions with members of the Federal Reserve System arranged by Federal funds brokers, as published on the next succeeding Business Day by the Federal Reserve Bank of New York, or, if such rate is not so published for any day that is a
Business Day, the average of the quotations for such day for such transactions received by the Administrative Agent from three Federal funds brokers of recognized standing selected by it; provided that if such rate shall be less than zero,
such rate shall be deemed to be zero for purposes of this Agreement. 
 “Loan Documents” means this
Agreement, the First Amendment, the Second Amendment, the Notes, the Fee Letter, the Letter of Credit Agreements, the Letters of Credit, any Intercreditor Agreement and the Security Instruments. 

“Sanctioned Country” means, at any time, a country, territory or region which is itself, or whose government
is, the subject or target of any Sanctions (including, at the time of this Agreement, Cuba, Iran, North Korea, Sudan and Syria). 
 2.3
Amendment to Definition of “Defaulting Lender”. Clause (d) immediately prior to the proviso of the definition of “Defaulting Lender” contained in Section 1.02 of the Credit Agreement is hereby amended and
restated in its entirety to read in full as follows: 
 (d) has, or has a direct or indirect parent company that has,
(i) become the subject of a proceeding under any bankruptcy or insolvency law, (ii) had appointed for it a receiver, custodian, conservator, trustee, administrator, assignee for the benefit of creditors or similar Person charged with
reorganization or liquidation of its business or assets, including the Federal Deposit Insurance Corporation or any other state or federal regulatory authority acting in such a capacity, or (iii) become subject to a Bail-In Action; 

2.4 Amendment to Section 2.06(c) of the Credit Agreement. Section 2.06(c)(iv)(A) of the Credit Agreement is hereby amended
and restated in its entirety to read as follows: 
 (A) such increase shall not be less than $50,000,000 unless the

  
 Page 5 

 
Administrative Agent otherwise consents, and no such increase shall be permitted if after giving effect thereto the aggregate value of all increases to the Commitments following the Second
Amendment Effective Date and during the remainder of the Availability Period would exceed $200,000,000; 
 2.5 Amendment to
Section 4.04 of the Credit Agreement. The last sentence of Section 4.04(a)(iv) of the Credit Agreement is hereby amended and restated in its entirety as follows: 

Subject to Section 12.17, no reallocation hereunder shall constitute a waiver or release of any claim of any party
hereunder against a Defaulting Lender arising from that Lender having become a Defaulting Lender, including any claim of a Non-Defaulting Lender as a result of such Non-Defaulting Lender’s increased exposure following such reallocation. 

2.6 Amendment to Section 7.20 of the Credit Agreement. Section 7.20 of the Credit Agreement is hereby amended and restated in
its entirety to read as follows: 
 Section 7.20 Use of Loans and Letters of Credit. The proceeds of the Loans
and the Letters of Credit shall be used 2.7 to fund Capital Expenditures and permitted investments, 2.8 to provide working capital, and 2.9 for general business purposes, including fees and expenses. The Parent and the Restricted Subsidiaries
are not engaged principally, or as one of its or their important activities, in the business of extending credit for the purpose, whether immediate, incidental or ultimate, of buying or carrying margin stock (within the meaning of Regulation T, U or
X of the Board). No part of the proceeds of any Loan or Letter of Credit will be used for any purpose which violates the provisions of Regulations T, U or X of the Board. The Borrower will not request any Borrowing or Letter of Credit, and the
Borrower shall not use, and the Parent and the Borrower shall procure that its Subsidiaries and its or their respective directors, officers, employees and agents shall not use, or lend, contribute or otherwise make available, the proceeds of any
Borrowing or Letter of Credit to any subsidiary, joint venture partner or any other Person (a) in furtherance of an offer, payment, promise to pay, or authorization of the payment or giving of money, or anything else of value, to any Person in
violation of any Anti-Corruption Laws, (b) for the purpose of funding, financing or facilitating any activities, business or transaction of or with any Sanctioned Person, or in any Sanctioned Country, or (c) in any manner that would
knowingly or negligently result in the violation of any Sanctions applicable to any party hereto (whether as underwriter, advisor, investor, lender, hedge provider, facility or security agent or otherwise). 

2.7 New EU Bail-In Representation and Warranty. A new Section 7.26 is hereby added to the Credit Agreement immediately following
Section 7.25 thereof, which new Section 7.26 shall read in full as follows: 

  
 Page 6 

 Section 7.26 EEA Financial Institutions. None of the Parent, the
Borrower and the Restricted Subsidiaries is an EEA Financial Institution. 
 2.8 Amendment to Section 8.03 of the Credit
Agreement. Section 8.03 of the Credit Agreement is hereby amended by adding a new sentence at the end of such Section, which new sentence shall read in full as follows: 

Parent and the Borrower will, and will cause each Restricted Subsidiary to maintain its legal existence in Delaware, another
State within the United States of America or the District of Columbia. 
 2.9 Amendments to Articles VIII and IV of the Credit
Agreement. The lead-in sentence of Article VIII and Article IX of the Credit Agreement are hereby amended by (a) deleting the phrase “all Letters of Credit have expired” and (b) inserting in place of such phrase, the phrase
“all Letters of Credit have expired (without any pending drawings thereon)”. 
 2.10 Amendment to Section 12.05(a) of the
Credit Agreement. Section 12.05(a) of the Credit Agreement is hereby amended by (a) deleting the phrase “any Letter of Credit is outstanding” and (b) inserting in place of such phrase, the phrase “any Letter of
Credit is outstanding (or any drawing is pending on any Letter of Credit)”. 
 2.11 New EU Bail-In Agreement and
Acknowledgement. A new Section 12.17 is hereby added to the Credit Agreement immediately following Section 12.16 thereof, which new Section 12.17 shall read in full as follows: 

Section 12.17 Acknowledgement and Consent to Bail-In of EEA Financial Institutions. Notwithstanding anything to the
contrary in any Loan Document or in any other agreement, arrangement or understanding among any such parties, each party hereto acknowledges that any liability of any EEA Financial Institution arising under any Loan Document, to the extent such
liability is unsecured, may be subject to the Write-Down and Conversion Powers of an EEA Resolution Authority and agrees and consents to, and acknowledges and agrees to be bound by: 

(a) the application of any Write-Down and Conversion Powers by an EEA Resolution Authority to any such liabilities arising
hereunder which may be payable to it by any party hereto that is an EEA Financial Institution; and 
 (b) the effects of any
Bail-In Action on any such liability, including, if applicable: 
 (i) a reduction in full or in part or cancellation of any
such liability; 
 (ii) a conversion of all, or a portion of, such liability into shares or other instruments of ownership in
such EEA Financial Institution, its parent undertaking, or a bridge institution that may be issued to it or otherwise conferred on it, and that such shares or other instruments of ownership will be accepted by it in lieu of any rights with respect
to any such liability under this Agreement or any other Loan Document; or 

  
 Page 7 

 (iii) the variation of the terms of such liability in connection with the
exercise of the Write-Down and Conversion Powers of any EEA Resolution Authority. 
 The provisions of this
Section 12.17 are intended to comply with, and shall be interpreted in light of, Article 55 of Directive 2014/59/EU of the European Parliament and of the Council of the European Union. 

2.12 Replacement of Annex I. Annex I to the Credit Agreement is hereby replaced in its entirety with Annex I attached hereto and
Annex I attached hereto shall be deemed to be attached as Annex I to the Credit Agreement. After giving effect to this Second Amendment and any Borrowings made on the Second Amendment Effective Date, (a) each Lender who holds Loans in an
aggregate amount less than its Applicable Percentage (after giving effect to this Second Amendment) of all Loans shall advance new Loans which shall be disbursed to the Administrative Agent and used to repay Loans outstanding to each Lender who
holds Loans in an aggregate amount greater than its Applicable Percentage of all Loans, (b) each Lender’s participation in each Letter of Credit, if any, shall be automatically adjusted to equal its Applicable Percentage (after giving
effect to this Second Amendment), (c) such other adjustments shall be made as the Administrative Agent shall specify so that the Revolving Credit Exposure applicable to each Lender equals its Applicable Percentage (after giving effect to this
Second Amendment) of the aggregate Revolving Credit Exposure of all Lenders and (d) upon request by each applicable Lender, the Borrower shall be required to make any break funding payments owing to such Lender that are required under
Section 5.02 of the Credit Agreement as a result of the Loans and adjustments described in this Section 2.12. For the avoidance of doubt, the increase in the aggregate Commitments of the Lenders effected by this Second Amendment
shall not be deemed to be an exercise by the Borrower of Section 2.06(c) of the Credit Agreement, and immediately after giving effect to this Second Amendment, the amount by which the Borrower may optionally increase the Commitments under
Section 2.06(c) of the Credit Agreement during the remainder of the Availability Period (subject to the conditions set forth in Section 2.06(c)(ii) of the Credit Agreement) remains $200,000,000. 

2.13 Replacement of Schedule 7.14. Schedule 7.14 to the Credit Agreement is hereby replaced in its entirety with Schedule 7.14
attached hereto and Schedule 7.14 attached hereto shall be deemed to be attached as Schedule 7.14 to the Credit Agreement. 

Section 3. Conditions Precedent. The effectiveness of this Second Amendment is subject to the following: 

3.1 The Administrative Agent shall have received counterparts of this Second Amendment from the Credit Parties, each New Lender, each other
Lender whose Commitment is increasing in connection with this Second Amendment, and, in any event, from Lenders constituting the Majority Lenders (with the determination of “Majority Lenders” occurring immediately prior to giving effect to
this Second Amendment). 

  
 Page 8 

 3.2 The Administrative Agent shall have received all fees and other amounts due and payable on or
prior to the Second Amendment Effective Date including, without limitation, the amendment consent fees described in Section 3.3 below and the Commitment increase fees described in Section 3.4 below, in each case to the extent
invoiced at least two Business Days prior to the Second Amendment Effective Date (or such later late as the Borrower may agree in its sole discretion). 

3.3 The Administrative Agent shall have received, for the account of each of the Consenting Lenders (as defined below), amendment consent fees
in an aggregate amount for each such Consenting Lender equal to five basis points (0.05%) of such Consenting Lender’s Commitment that was in effect immediately prior to giving effect to Section 2.12 hereof. As used herein,
“Consenting Lender” means each Lender that was party to the Credit Agreement immediately prior to the Second Amendment Effective Date that has executed and delivered this Second Amendment on or prior to the Second Amendment
Effective Date. 
 3.4 The Administrative Agent shall have received, for the account of each of the Increasing Lenders (as defined below),
Commitment increase fees in an aggregate amount for each such Increasing Lender equal to fifty basis points (0.50%) of the amount of such Increasing Lender’s Increased Commitment (as defined below). As used herein, “Increasing
Lender” means each Lender (including the New Lenders) whose Commitment after giving effect to Section 2.12 hereof exceeds such Lender’s Commitment, if any, that was in effect immediately prior to giving effect to
Section 2.12 hereof, and “Increased Commitment” means the amount of such excess. 
 3.5 The Administrative
Agent shall have received duly executed Notes payable to each Lender (including each New Lender) that has requested a Note on or prior to the Second Amendment Effective Date in a principal amount equal to its Commitment (as amended hereby) dated as
of the Second Amendment Effective Date. 
 3.6 The Administrative Agent shall have received a certificate of a Responsible Officer of the
Borrower certifying: (a) that the Credit Parties, REI and the Vantage Parties have each received all consents and approvals necessary for the consummation of the Vantage Midstream Acquisition to the extent the failure to obtain such consents
and approvals would permit REI, the Parent or the Borrower to terminate the Vantage Acquisition Agreement or the Midstream Dropdown Agreement, as applicable, (b) that concurrently with the effectiveness of this Second Amendment and the
Borrowings to be made on the Second Amendment Effective Date, (i) REI is consummating the transactions contemplated by the Vantage Acquisition Agreement and (ii) the Credit Parties are consummating the Vantage Midstream Acquisition, in
each case substantially in accordance with the terms of the Vantage Acquisition Agreement and Midstream Dropdown Agreement, as applicable (without waiver or amendment of any term or condition of either such agreement in any manner materially adverse
to the interests of the Lenders without the prior written consent of the Administrative Agent, such consent not to be unreasonably withheld, conditioned or delayed)), (c) as to the final purchase price (and form of consideration, which shall
all be in cash) being paid by the Credit Parties to REI as consideration for the Vantage Midstream Acquisition after giving effect to all adjustments (if any) as of the closing date contemplated by the Midstream Dropdown Agreement, (d) that the
Parent shall have issued Equity Interests in accordance with Section 3.7 below, (e) the Credit Parties do not have any Debt for borrowed money other than Debt under the Loan Documents and Debt permitted under the Credit Agreement,
and (f) since September 26, 2016, the Credit Parties have not disposed of Collateral having a fair market value in excess of $5,000,000 in the aggregate. 

  
 Page 9 

 3.7 The Administrative Agent shall have received evidence reasonably satisfactory to it that,
during the period beginning on September 26, 2016 and ending on the Second Amendment Effective Date, the Parent shall have issued common Equity Interests in a private offering resulting in not less than $250,000,000 of gross cash proceeds to
Parent. 
 3.8 The Administrative Agent shall have received evidence reasonably satisfactory to it (including mortgage releases and UCC-3
financing statement terminations) that (a) all Liens on the Vantage Midstream Assets and the Equity Interests in each of the Vantage Midstream Entities (other than Permitted Liens) associated with any credit facilities and funded Debt have been
released or terminated, subject only to the filing of applicable terminations and releases (or arrangements for such release and termination reasonably satisfactory to the Administrative Agent have been made) and (b) all documents and
instruments evidencing financing arrangements of the Vantage Parties set forth on Annex II hereto, and any other Debt of the Vantage Midstream Entities (other than Debt permitted under the Credit Agreement) have been, or substantially concurrently
with the closing of the Vantage Midstream Acquisition shall be, redeemed, defeased or satisfied and discharged. 
 3.9 The Administrative
Agent shall have received duly executed counterparts of (a) an assumption agreement executed by each of the Vantage Midstream Entities pursuant to which each such Vantage Midstream Entity will become a Guarantor and become party to the Guaranty
and Collateral Agreement, (b) new mortgages executed by the applicable Vantage Midstream Entities covering the Midstream Properties, Deeds and Rights of Way comprising the Vantage Midstream Assets (but excluding all Buildings and Manufactured
(Mobile) Homes (each as defined in the applicable Flood Insurance Regulations)), and (c) mortgage amendments to reflect the increase in the aggregate Commitments effectuated pursuant to this Second Amendment and the exclusion of all Buildings
and Manufactured (Mobile) Homes (each as defined in the applicable Flood Insurance Regulations) from the Mortgaged Properties covered by the mortgages previously delivered by the Credit Parties prior to the Second Amendment Effective Date, in each
case in form and substance reasonably satisfactory to the Administrative Agent. In connection with the execution and delivery of such Security Instruments and other documents, the Administrative Agent shall be reasonably satisfied that it will have,
upon the recording of such Security Instruments and the requisite UCC financing statements, as applicable, first priority, perfected Liens (subject only to Permitted Liens) on (i) substantially all of the Vantage Midstream Assets, (ii) all
other Property of the Vantage Midstream Entities purported to be pledged as Collateral pursuant to the Guaranty and Collateral Agreement and (iii) all of the Equity Interests issued by each of the Vantage Midstream Entities (and to the extent
any such Equity Interests are certificated, the Borrower shall also have caused the applicable Credit Party to deliver the original stock certificates evidencing such Equity Interests together with an appropriate undated stock power for each
certificate duly executed in blank by the registered owner thereof). The Lenders hereby authorize and consent to the Administrative Agent’s execution and delivery of the mortgage amendments referred to in clause (c) above. 

3.10 To the extent reasonably requested in writing by the Administrative Agent at least 10 Business Days prior to the Second Amendment
Effective Date, the Administrative Agent 

  
 Page 10 

 
shall have received, not less than three Business Days prior to the Second Amendment Effective Date, from the Credit Parties, all documentation and other information required by regulatory
authorities under applicable “know your customer” and anti-money laundering rules and regulations, including the USA PATRIOT Act. 

3.11 The Administrative Agent shall have received a certificate of the Secretary, Assistant Secretary or a Responsible Officer of or with
respect to each Credit Party, including the Vantage Midstream Entities (which may be given by an officer of the General Partner on behalf of itself and the Parent and any other Credit Parties), setting forth (a) resolutions of the members,
board of directors or other appropriate governing body with respect to the authorization of such Credit Party to execute and deliver each Loan Document to which it is a party and to enter into the transactions contemplated in those documents,
(b) specimen signatures of authorized officers of such Credit Party, and (c) the limited liability company agreement, the articles or certificate of incorporation or formation and bylaws (or comparable organizational documents) of such
Credit Party, certified as being true and complete. 
 3.12 The Administrative Agent shall have received an opinion
of Thompson & Knight LLP, special counsel to the Borrower and the other Credit Parties, and of local counsel in the Commonwealth of Pennsylvania, in each case in form and substance reasonably satisfactory to the Administrative Agent.

 3.13 The Administrative Agent shall have received title information reasonably satisfactory to it with respect to the Vantage Midstream
Assets. 
 3.14 The Administrative Agent shall have received a certificate of a Responsible Officer of the Parent certifying that the Parent
and its Consolidated Restricted Subsidiaries, on a consolidated basis after giving effect to the Vantage Midstream Acquisition and the other transactions contemplated by this Second Amendment, are solvent. 

3.15 The Administrative Agent shall have received or shall have available on-line through the “Electronic Data Gathering, Analysis and
Retrieval” system (or any successor system thereof) maintained by the SEC (or any succeeding governmental authority) (a) audited consolidated balance sheets and related statements of income, stockholders’ equity and cash flows of the
Parent and its Consolidated Restricted Subsidiaries, for the three most recently completed fiscal years ended at least 105 days before the Second Amendment Effective Date, (b) unaudited consolidated balance sheets and related statements of
income, stockholders’ equity and cash flows of the Parent and its Consolidated Subsidiaries, for each subsequent fiscal quarter (other than the fourth fiscal quarter of any fiscal year) ended at least 55 days before the Second Amendment
Effective Date (in each case, together with the corresponding comparative period from the prior fiscal year), (c) audited consolidated balance sheets as of December 31, 2013, December 31, 2014 and December 31, 2015 and the
related statements of income, stockholders’ equity and cash flows of (A) Vantage Energy, LLC, (B) Vantage Energy II, LLC and (C) Vista Gathering, LLC, in each case, for the fiscal years ended December 31,
2013, December 31, 2014 and December 31, 2015, (d) unaudited consolidated balance sheets and related statements of income, stockholders’ equity and cash flows of (A) Vantage Energy, LLC, (B) Vantage Energy II, LLC
and (C) Vista Gathering, LLC, in each case, for each subsequent interim fiscal period (other than the fourth fiscal quarter of any fiscal year) ended at least 45 days before the Second 

  
 Page 11 

 
Amendment Effective Date (in each case, together with the corresponding comparative period from the prior fiscal year), and (e) (i) a pro forma consolidated balance sheet of the Parent
as of the Second Amendment Effective Date and (ii) pro forma consolidated projected statements of income, stockholders’ equity and cash flows for the Parent prepared on a quarterly basis for the fiscal years ending December 31, 2016
and December 31, 2017, in each case, prepared after giving effect to the Vantage Midstream Acquisition and the other transactions contemplated by this Second Amendment. 

3.16 As of the Second Amendment Effective Date, after giving effect to the amendments to the Credit Agreement contained in this Second
Amendment and to the consummation of the Vantage Midstream Acquisition, the total Commitments shall exceed the total Revolving Credit Exposure by not less than $300,000,000. 

3.17 The Administrative Agent shall have received certificates of the appropriate state agencies with respect to the existence, qualification
and good standing of the Borrower and each other Credit Party. 
 3.18 The Administrative Agent shall have received a certificate of
insurance coverage of each of the Vantage Midstream Entities evidencing that the Vantage Midstream Entities are carrying insurance in accordance with Section 7.12 of the Credit Agreement. 

3.19 The Administrative Agent shall have received a Borrowing Request in accordance with Section 2.03 of the Credit Agreement in
connection with any Borrowing to be made by the Borrower to fund a portion of the consideration being paid by the Credit Parties to REI and/or its subsidiaries in connection with the Vantage Midstream Acquisition. 

3.20 The Purchase Agreement Representations (as defined below) shall be true and correct and the Specified Representations (as defined below)
shall be true and correct in all material respects (except in the case of any Specified Representation which expressly relates to a given date or period, such representation and warranty shall be true and correct in all material respects as of the
respective date or for the respective period, as the case may be); provided, that to the extent that any Specified Representation is qualified by or subject to a “material adverse effect”, “material adverse change” or
similar term or qualification, the same shall be true and correct in all respects. As used herein, “Purchase Agreement Representations” means the representations made by or on behalf of the Vantage Parties in the Vantage Acquisition
Agreement (including those contained in Article IV thereof) as are material to the interests of the Lenders (in their capacities as such), but only to the extent that REI has the right to terminate its obligations under the Vantage Acquisition
Agreement or decline to consummate the transactions contemplated by the Vantage Acquisition Agreement as a result of a breach of such representations in the Vantage Acquisition Agreement, and “Specified Representations” means the
representations and warranties contained in Sections 7.01, 7.02, 7.03 (solely with respect to clause (b) thereof), 7.08, 7.20, 7.21 (with respect to solvency of the Parent and its Consolidated Restricted Subsidiaries, on a consolidated basis
after giving effect to the Vantage Midstream Acquisition and the other transactions contemplated by this Second Amendment) and 7.22 of the Credit Agreement. 

3.21 Since December 31, 2015, there shall not have occurred a Material Adverse Effect (as defined in the Vantage Acquisition Agreement)
or a Rice Material Adverse Effect (as defined in the Midstream Dropdown Agreement). 

  
 Page 12 

 Section 4. New Lenders. Each New Lender hereby joins in, becomes a party to, and
agrees to comply with and be bound by the terms and conditions of the Credit Agreement as a Lender thereunder and under each and every other Loan Document to which any Lender is required to be bound by the Credit Agreement, to the same extent as if
such New Lender were an original signatory thereto. Each New Lender hereby appoints and authorizes the Administrative Agent to take such action as agent on its behalf and to exercise such powers and discretion under the Credit Agreement as are
delegated to the Administrative Agent by the terms thereof, together with such powers and discretion as are reasonably incidental thereto. Each New Lender represents and warrants that (a) it has full power and authority, and has taken all
action necessary, to execute and deliver this Second Amendment, to consummate the transactions contemplated hereby and to become a Lender under the Credit Agreement, (b) it has received a copy of the Credit Agreement and copies of the most
recent financial statements delivered pursuant to Section 8.01 thereof, and such other documents and information as it has deemed appropriate to make its own credit analysis and decision to enter into this Second Amendment and to become a
Lender on the basis of which it has made such analysis and decision independently and without reliance on the Administrative Agent or any other Lender, and (c) from and after the Second Amendment Effective Date, it shall be a party to and be
bound by the provisions of the Credit Agreement and the other Loan Documents and have the rights and obligations of a Lender thereunder. 

Section 5. Limited Conditionality Provisions with respect to Funding of Loans on Second Amendment Effective Date. Notwithstanding
anything to the contrary contained in this Second Amendment or the Credit Agreement, the Lenders party hereto agree that (a) Section 6.02 of the Credit Agreement shall not be applicable solely to the making of any Loans on the Second
Amendment Effective Date to be used to consummate the Vantage Midstream Acquisition and (b) the only conditions to the effectiveness of this Second Amendment and to the making of such Loans on the Second Amendment Effective Date are those set
forth in Section 3 hereof. 
 Section 6. Post-Second Amendment Effective Date Deliverables. 

6.1 Flood Information and Flood Insurance. On or prior to the date that is ninety (90) days following the Second Amendment
Effective Date (or such later date as the Administrative Agent may agree in its sole discretion and notwithstanding any applicable deadlines for these deliverables set forth in Section 8.14(a) of the Credit Agreement), the Borrower shall have
delivered to the Administrative Agent (i) a certificate of a Responsible Officer of the Parent certifying as to a true, correct and complete list, as of the date of such certificate, of all “Buildings” and “Manufactured (Mobile)
Homes” (each as defined by the applicable Flood Insurance Regulations) located on real property that is subject to Liens created by the Security Instruments (which list shall specify the number of buildings at each location and shall include a
full legal description sufficient to obtain the flood determinations described in the following clause (ii)), (ii) a life of loan flood hazard determination with respect to all Midstream Properties on which there exists a Building,
(iii) if such real property is located in a special flood hazard area, evidence of flood insurance in such amounts as are acceptable to the Administrative Agent and in compliance with all applicable Flood Insurance Regulations, and
(iv) such other certificates or notices reasonably required by the Administrative Agent to facilitate compliance with Governmental Requirements, each in form and substance reasonably satisfactory to the Administrative Agent. 

  
 Page 13 

 6.2 Mortgages. On or prior to the date that is ninety (90) days following the Second
Amendment Effective Date (or such later date as the Administrative Agent may agree in its sole discretion and notwithstanding any applicable deadlines for these deliverables set forth in Section 8.14(a) of the Credit Agreement), the Borrower
shall deliver to the Administrative Agent mortgages (or amendments to existing mortgages) and other Security Instruments sufficient to create first priority, perfected Liens (subject only to Permitted Liens) on all “Buildings” and
“Manufactured (Mobile) Homes” (each as defined in the applicable Flood Insurance Regulations) located on real property that is subject to Liens created by the Security Instruments. 

6.3 Control Agreements. On or prior to the date that is sixty (60) days following the Second Amendment Effective Date (or such
later date as the Administrative Agent may agree in its sole discretion and notwithstanding any applicable deadlines for these deliverables set forth in the Guaranty and Collateral Agreement), the Borrower shall deliver to the Administrative Agent
duly executed Control Agreements with respect to each Deposit Account, Securities Account and Commodity Account (other than, in each case, De Minimis Accounts) maintained by any Vantage Midstream Entity. Each capitalized term used in this
Section 6.3 and not otherwise defined in this Second Amendment shall have the meaning given to such term in the Guaranty and Collateral Agreement. 

The Borrower’s failure to timely comply with this Section 6, after giving effect to any extension contemplated in this
Section 6 and agreed to by the Administrative Agent in its sole discretion, shall constitute an immediate Event of Default without notice or cure periods. 

Section 7. Miscellaneous. 

7.1 Confirmation and Effect. The provisions of the Credit Agreement (as amended by this Second Amendment) shall remain in full force
and effect in accordance with its terms following the effectiveness of this Second Amendment, and this Second Amendment shall not constitute a waiver of any provision of the Credit Agreement or any other Loan Document, except as expressly provided
for herein. Each reference in the Credit Agreement to “this Agreement”, “hereunder”, “hereof’, “herein”, or words of like import shall mean and be a reference to the Credit Agreement as amended hereby, and
each reference to the Credit Agreement in any other document, instrument or agreement executed and/or delivered in connection with the Credit Agreement shall mean and be a reference to the Credit Agreement as amended hereby. 

7.2 Ratification and Affirmation of Credit Parties. Each of the Credit Parties hereby expressly (i) acknowledges the terms of this
Second Amendment, (ii) ratifies and affirms its obligations under the Guaranty and Collateral Agreement and the other Loan Documents to which it is a party, (iii) acknowledges, renews and extends its continued liability under the Guaranty
and Collateral Agreement and the other Loan Documents to which it is a party, (iv) agrees that its guarantee under the Guaranty and Collateral Agreement and the other Loan Documents to which it is a party remains in full force and effect with
respect to the Obligations as amended hereby, (v) represents and warrants to the Lenders and the Administrative Agent that 

  
 Page 14 

 
each representation and warranty of such Credit Party contained in the Credit Agreement and the other Loan Documents to which it is a party is true and correct in all material respects as of the
date hereof and after giving effect to the amendments set forth in Section 2 hereof except (A) to the extent any such representations and warranties are expressly limited to an earlier date, in which case, on and as of the date
hereof, such representations and warranties shall continue to be true and correct as of such specified earlier date, and (B) to the extent that any such representation and warranty is expressly qualified by materiality or by reference to
Material Adverse Effect, such representation and warranty (as so qualified) shall continue to be true and correct in all respects, (vi) represents and warrants to the Lenders and the Administrative Agent that the execution, delivery and
performance by such Credit Party of this Second Amendment are within such Credit Party’s corporate, limited partnership or limited liability company powers (as applicable), have been duly authorized by all necessary action and that this Second
Amendment constitutes the valid and binding obligation of such Credit Party enforceable in accordance with its terms, except as the enforceability thereof may be limited by bankruptcy, insolvency or similar laws affecting creditor’s rights
generally, and (vii) represents and warrants to the Lenders and the Administrative Agent that, immediately before, and after giving effect to this Second Amendment, no Event of Default exists. 

7.3 Counterparts. This Second Amendment may be executed by one or more of the parties hereto in any number of separate counterparts,
and all of such counterparts taken together shall be deemed to constitute one and the same instrument. Delivery of this Second Amendment by facsimile or electronic (e.g. pdf) transmission shall be effective as delivery of a manually executed
original counterpart hereof. 
 7.4 No Oral Agreement. THIS WRITTEN SECOND
AMENDMENT, THE CREDIT AGREEMENT AND THE OTHER LOAN DOCUMENTS EXECUTED IN
CONNECTION HEREWITH AND THEREWITH REPRESENT THE FINAL AGREEMENT BETWEEN THE PARTIES
AND MAY NOT BE CONTRADICTED BY EVIDENCE OF PRIOR, CONTEMPORANEOUS, OR
UNWRITTEN ORAL AGREEMENTS OF THE PARTIES. THERE ARE NO SUBSEQUENT ORAL
AGREEMENTS BETWEEN THE PARTIES THAT MODIFY THE AGREEMENTS OF THE PARTIES
IN THE CREDIT AGREEMENT AND THE OTHER LOAN DOCUMENTS. 

7.5 Governing Law. THIS SECOND AMENDMENT (INCLUDING, BUT
NOT LIMITED TO, THE VALIDITY AND ENFORCEABILITY HEREOF) SHALL BE GOVERNED
BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF
NEW YORK. 
 7.6 Payment of Expenses. The Borrower agrees to pay or reimburse the Administrative Agent
for all of its reasonable out-of-pocket costs and expenses incurred in connection with this Second Amendment, any other documents prepared in connection herewith and the transactions contemplated hereby, in each case to the extent required under
Section 12.03 of the Credit Agreement. 
 7.7 Severability. Any provision of this Second Amendment which is prohibited or
unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such prohibition or unenforceability in any
jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. 

  
 Page 15 

 7.8 Successors and Assigns. This Second Amendment shall be binding upon and inure to the
benefit of the parties hereto and their respective successors and assigns. 
 [Signature Pages Follow.] 

  
 Page 16 

 The parties hereto have caused this Second Amendment to be duly executed as of the day and year
first above written. 
  

							
	    PARENT:	 		 	RICE MIDSTREAM PARTNERS LP,
		 		 	a Delaware limited partnership
			
		 		 	 By: Rice Midstream Management LLC,

a Delaware limited liability company, its
 general
partner

				
		 		 	By:	 	 /s/ Grayson T. Lisenby

		 		 	Name:	 	Grayson T. Lisenby
		 		 	Title:	 	Senior Vice President and Chief
		 		 		 	Financial Officer
			
	    BORROWER:	 		 	RICE MIDSTREAM OPCO LLC,
		 		 	a Delaware limited liability company
				
		 		 	By:	 	 /s/ Grayson T. Lisenby

		 		 	Name:	 	Grayson T. Lisenby
		 		 	Title:	 	Senior Vice President and Chief
		 		 		 	Financial Officer

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

							
	GUARANTORS:	 		 	RICE POSEIDON MIDSTREAM LLC,
		 		 	a Delaware limited liability company
				
		 		 	By:	 	 /s/ Grayson T. Lisenby

		 		 	Name:	 	Grayson T. Lisenby
		 		 	Title:	 	Senior Vice President and Chief
		 		 		 	Financial Officer
			
		 		 	 RICE WATER SERVICES (OH) LLC,

a Delaware limited liability company

				
		 		 	 By:
	 	 /s/ Grayson T. Lisenby

		 		 	 Name:
	 	Grayson T. Lisenby
		 		 	 Title:
	 	Senior Vice President and Chief
		 		 		 	Financial Officer
			
		 		 	 RICE WATER SERVICES (PA) LLC,

a Delaware limited liability company

				
		 		 	By:	 	 /s/ Grayson T. Lisenby

		 		 	Name:	 	Grayson T. Lisenby
		 		 	Title:	 	Senior Vice President and Chief
		 		 		 	Financial Officer
			
		 		 	 VANTAGE ENERGY II ACCESS, LLC,

a Delaware limited liability company

				
		 		 	By:	 	 /s/ Grayson T. Lisenby

		 		 	Name:	 	Grayson T. Lisenby
		 		 	Title:	 	Senior Vice President and Chief
		 		 		 	Financial Officer
			
		 		 	 VISTA GATHERING, LLC,
 a
Delaware limited liability company

				
		 		 	By:	 	 /s/ Grayson T. Lisenby

		 		 	Name:	 	Grayson T. Lisenby
		 		 	Title:	 	Senior Vice President and Chief
		 		 		 	Financial Officer

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
					
	WELLS FARGO BANK, N.A., as Administrative Agent and as a Lender
			
		 	By: 	 	 /s/ Matthew W. Coleman

		 	Name:    Matthew W. Coleman
		 	Title:      Director

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	BARCLAYS BANK PLC, as a Lender
		
	By: 	 	 /s/ Vanessa A. Kurbatsky

	Name:    Vanessa A. Kurbatsky
	Title:      Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	BMO HARRIS BANK N.A., as a Lender
		
	By: 	 	 /s/ Gumaro Tijerina

	Name:    Gumaro Tijerina
	Title:      Managing Director

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	CITIBANK, N.A., as a Lender
		
	By: 	 	 /s/ Peter Kardos

	Name:    Peter Kardos
	Title:      Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	FIFTH THIRD BANK, as a Lender
		
	By:	 	 /s/ Justin Bellamy

	Name:    Justin Bellamy
	Title:      Director

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	ROYAL BANK OF CANADA, as a Lender
		
	By: 	 	 /s/ Evans Swann, Jr.

	Name:    Evans Swann, Jr.
	Title:      Authorized Signatory

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	 CAPITAL ONE, NATIONAL

ASSOCIATION, as a Lender

		
	By: 	 	 /s/ Kristin N. Oswald

	Name:    Kristin N. Oswald
	Title:      Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	COMERICA BANK, as a Lender
		
	By: 	 	 /s/ William B. Robinson

	Name:    William B. Robinson
	Title:      Senior Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	 PNC BANK, NATIONAL

ASSOCIATION, as a Lender

		
	By: 	 	 /s/ Jessica McGuire

	Name:     Jessica McGuire
	Title:       Assistant Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	SUNTRUST BANK, as a Lender
		
	By: 	 	 /s/ Chulley Bogle

	Name:     Chulley Bogle
	Title:       Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	COMPASS BANK, as a Lender
		
	By: 	 	 /s/ Les Werme

	Name:     Les Werme
	Title:       Director

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	 U.S. BANK NATIONAL ASSOCIATION,

as a Lender

		
	By: 	 	 /s/ Heather Han

	Name:     Heather Han
	Title:       Senior Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	 ZB, N.A. DBA AMEGY BANK, as a

Lender

		
	By: 	 	 /s/ John Moffitt

	Name:     John Moffitt
	Title:       Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	CITIZENS BANK NA,
	as a Lender
		
	By: 	 	 /s/ Scott Donaldson

	Name:    Scott Donaldson
	Title:      Senior Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	JPMORGAN CHASE BANK, N.A.,
	as a Lender
		
	By: 	 	 /s/ Justin Crawford

	Name:    Justin Crawford
	Title:      Authorized Signatory

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	DEUTSCHE BANK AG NEW YORK,
	as a Lender
		
	By: 	 	 /s/ Chris Chapman

	Name:    Chris Chapman
	Title:      Director
		
	By:	 	 /s/ Susan Fornies

	Name:    Susan Fornies
	Title:      Assistant Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	THE HUNTINGTON NATIONAL BANK,
	as a Lender
		
	By: 	 	 /s/ Jason A. Zilewicz

	Name:     Jason A. Zilewicz
	Title:       Vice President

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC] 

 
			
	ABN AMRO CAPITAL USA LLC,
	as a Lender
		
	By: 	 	 /s/ Darrell Holley

	Name:     Darrell Holley
	Title:       Managing Director
		
	By:	 	 /s/ David Montgomery

	Name:     David Montgomery
	Title:       Executive Director

  
 [SIGNATURE
PAGE TO SECOND AMENDMENT TO CREDIT AGREEMENT – RICE MIDSTREAM OPCO LLC]

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