Document:

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                                                                    EXHIBIT 10.9

**CERTAIN CONFIDENTIAL MATERIAL CONTAINED IN THIS DOCUMENT HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO 17
C.F.R. SUBSECTION 200.80(B)(4), 200.83 AND 230.406.**

                     EXCLUSIVE LICENSE AND SUPPLY AGREEMENT

                                     BETWEEN

                            ICN PHARMACEUTICALS, INC.

                                       AND

                              SCHERING-PLOUGH LTD.

                                  JULY 28, 1995
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                                TABLE OF CONTENTS

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                                    ARTICLE I

DEFINITIONS ..............................................................     1
   1.1  "Affiliate" ......................................................     1
   1.2  "Cost of Goods" ..................................................     1
   1.3  "CPMP Opinion" ...................................................     2
   1.4  "Effective Date" .................................................     2
   1.5  "EU" .............................................................     2
   1.6  "Exclusive Period" ...............................................     2
   1.7  "FDA" ............................................................     2
   1.8  "ICN" ............................................................     2
   1.9  "ICN Facility" ...................................................     2
   1.10 "ICN Trademark" ..................................................     3
   1.11 "Improvements" ...................................................     3
   1.12 "Know-How" .......................................................     3
   1.13 "Labelling" ......................................................     3
   1.14 "License Period" .................................................     3
   1.15 "Major Market" ...................................................     3
   1.16 "Minimum Labelling" ..............................................     3
   1.17 "NDA" ............................................................     3
   1.18 "Net Sales" ......................................................     4
   1.19 "Product" ........................................................     4
   1.20 "Product Price" ..................................................     5
   1.21 "Product Specifications" .........................................     5
   1.22 "Regulatory Approval" ............................................     5
   1.23 "Schering" .......................................................     5
   1.24 "Schering Trademark" .............................................     5
   1.25 "Stock Purchase Agreement" .......................................     5
   1.26 "Territory" ......................................................     5

                                    ARTICLE 2

GRANT OF RIGHTS TO SCHERING ..............................................     5
   2.1  Grant of Exclusive License .......................................     5
   2.2  Acceptance of Appointment ........................................     6
   2.3  ICN Retained Rights ..............................................     6
   2.4  Prices ...........................................................     6
   2.5  Know-How .........................................................     7
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   2.6  Approvals; Effective Date ........................................     7

                                    ARTICLE 3

CERTAIN DEVELOPMENT AND REGULATORY MATTERS DURING EXCLUSIVE PERIOD .......     7
   3.1  Research and Development Activities ..............................     7
   3.2  Product Registrations ............................................     9
   3.3  Pricing and Reimbursement Approvals ..............................    12
   3.4  Failure to Obtain Approvals; Restrictions ........................    12
   3.5  Governmental Inspections .........................................    13
   3.6  Notice of Adverse Reactions ......................................    13
   3.7  Recalls and Market Withdrawals ...................................    14
   3.8  Additional Indications ...........................................    14
   3.9  Improvements .....................................................    15

                                    ARTICLE 4

CERTAIN OBLIGATIONS OF THE PARTIES DURING EXCLUSIVE PERIOD ...............    16
   4.1  Diligence in Marketing the Product ...............................    16
   4.2  Compliance with Laws .............................................    17
   4.3  Trademark Registration and Infringements .........................    17

                                    ARTICLE 5

MARKETING ACTIVITIES .....................................................    20
   5.1  Establishment of Scientific and Commercial Liaison Committees ....    20
   5.2  Product Labelling ................................................    21
   5.3  Product Sampling .................................................    22

                                    ARTICLE 6

COMPENSATION PAYABLE TO ICN; PAYMENT TERMS ...............................    22
    6.1  License Fee .....................................................    22
    6.2  Royalty Payment .................................................    23
    6.3  Royalty Reduction ...............................................    23
    6.4  Product Price to Schering .......................................    23
    6.5  Royalty Payment Dates ...........................................    24
    6.6  Direct Affiliate Licenses, Supporting Licenses and Compulsory
         Royalties .......................................................    25
    6.7  Place of Royalty Payment and Currency Conversions ...............    25
    6.8  Royalties on Resales ............................................    26
</TABLE>

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    6.9  Duration of Royalty Payments ....................................    26
    6.10 Maintenance of Royalty Records; Audit Rights ....................    26
    6.11 Equity Purchase .................................................    27
    6.12 Withholding Taxes, etc ..........................................    27

                                    ARTICLE 7

ICN'S MARKETING RIGHTS; DISTRIBUTION .....................................    28
    7.1  ICN's Marketing Rights ..........................................    28
    7.2  Distribution ....................................................    28
    7.3  Ireland Sales ...................................................    29

                                    ARTICLE 8

SUPPLY OF PRODUCT BY ICN DURING EXCLUSIVE PERIOD .........................    30
    8.1  Supply ..........................................................    30
    8.2  Forecasts and Procedures ........................................    30
    8.3  Schering's Right to Manufacture .................................    32
    8.4  Limited Warranty ................................................    34
    8.5  Rejection of Product ............................................    35

                                    ARTICLE 9

CONFIDENTIALITY ..........................................................    35
    9.1  Confidentiality .................................................    35
    9.2  No Publicity ....................................................    36

                                   ARTICLE 10

REPRESENTATIONS AND WARRANTIES ...........................................    37
   10.1  Representations and Warranties of Each Party ....................    37
   10.2  ICN'S Representations ...........................................    38
   10.3  Continuing Representations ......................................    39
   10.4  No Inconsistent Agreements ......................................    39

                                   ARTICLE 11

INDEMNIFICATION AND LIMITATION ON LIABILITY ..............................    40
   11.1  Indemnification by Schering .....................................    40
   11.2  Indemnification by ICN ..........................................    40
   11.3  Conditions to Indemnification....................................    40
   11.4  Settlements .....................................................    41
   11.5  Limitation of Liability .........................................    41
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       11.6  Insurance ...................................................    42

                                   ARTICLE 12

TERM AND TERMINATION .....................................................    42
      12.1  Term of Agreement ............................................    42
      12.2  Termination by Either Party ..................................    42
      12.3  Continuing Obligations .......................................    43
      12.4  Partial Termination of Territory by ICN ......................    43
      12.5  Effects of Termination by Schering ...........................    43
      12.6  Effects of Termination by ICN ................................    45
      12.7  Change of Control ............................................    45
      12.8  Remedy Not Exclusive .........................................    46

                                   ARTICLE 13

DISPUTE RESOLUTION .......................................................    46

                                   ARTICLE 14

PROVISION FOR INSOLVENCY .................................................    50

                                   ARTICLE 15

MISCELLANEOUS ............................................................    52
      15.1  Assignment ...................................................    52
      15.2  Governing Law ................................................    52
      15.3  Waiver .......................................................    52
      15.4  Independent Relationship .....................................    52
      15.5  Export Control ...............................................    52
      15.6  Entire Agreement; Amendment...................................    52
      15.7  Notices ......................................................    53
      15.8  Force Majeure ................................................    54
      15.9  Non-Solicitation .............................................    54
      15.10 Severability .................................................    54
      15.11 Counterparts .................................................    55

GUARANTEE ................................................................    57

EXHIBIT A ................................................................    A-1
      Cost of Goods ......................................................    A-1

EXHIBIT B ................................................................    B-1
      PRODUCT SPECIFICATIONS .............................................    B-1
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EXHIBIT C ................................................................   C-1
      STOCK PURCHASE AGREEMENT ...........................................   C-1

EXHIBIT D ................................................................   D-1
      RESEARCH AND DEVELOPMENT PLANS......................................   D-1

EXHIBIT E.................................................................   E-1
      ADVERSE EVENT REPORTING PROCEDURES..................................   E-1

EXHIBIT F.................................................................   F-1
      PUBLICATION PROCEDURES..............................................   F-1
EXHIBIT 2.1
      LICENSE AGREEMENTS..................................................
</TABLE>

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                     EXCLUSIVE LICENSE AND SUPPLY AGREEMENT

                  This EXCLUSIVE LICENSE AND SUPPLY AGREEMENT ("Agreement") is
made as of July 28, 1995, by and between ICN PHARMACEUTICALS, INC., a Delaware
corporation ("ICN"), and SCHERING-PLOUGH LTD., a corporation organized under the
laws of Switzerland ("Schering"), each on behalf of itself and its Affiliates.
ICN and Schering are sometimes referred to herein individually as a "Party" and
collectively as the "Parties."

                  WHEREAS, ICN has developed ribavirin, an oral antiviral
product; and WHEREAS, Schering wishes to obtain a license to use the know-how
and data developed by ICN concerning ribavirin; and

                  WHEREAS, Schering wishes to market, sell and distribute the
Product (as hereinafter defined) for the treatment of chronic hepatitis C under
the terms and conditions of this Agreement; and

                  WHEREAS, ICN wishes to grant Schering such right under the
terms and conditions of this Agreement and any and all exhibits hereto.

                  NOW, THEREFORE, in consideration of the mutual promises
contained herein and intending to be legally bound hereby, the Parties hereby
agree as follows:

                                    ARTICLE I

                                   DEFINITIONS

                  As used in this Agreement, the following capitalized terms
shall have the meanings set forth below. Capitalized terms in this Agreement
used in the plural shall have the meaning as for the singular and vice versa.

                  1.1 "Affiliate" means any individual or entity directly or
indirectly controlling, controlled by or under common control with, the
specified individual or entity. For purposes of this Agreement, the direct or
indirect ownership of over 50% of the outstanding voting securities of an
entity, or the right to receive over 50% of the profits or earnings of an entity
shall be deemed to constitute control. Such other relationship as in fact
results in actual control over the management, business and affairs of an
entity, shall also be deemed to constitute control.

                  1.2 "Cost of Goods" means the cost to ICN or Schering, as the
case may be, of Products shipped in finished bulk capsules. As used herein, the
cost of the Product means (i) in the case of products and services acquired from
third parties, payments made to such third parties, and (ii) in the case of
manufacturing services performed by the

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Parties, including manufacturing services in support of third party
manufacturing, the actual unit costs of manufacture in bulk form or final
manufacturing, as the case may be. Actual unit costs shall consist only of
direct material and direct labor costs plus manufacturing overhead directly
attributable to the Product at standard cost, all calculated in accordance with
reasonable cost accounting methods, consistently applied, of the party
performing the work, and as more fully set forth on Exhibit A hereto.

                  1.3 "CPMP Opinion" means a final, written majority or
unanimous positive opinion by the committee on Proprietary Medicinal Products of
the European Community ("CPMP"), or any successor to the CPMP.

                  1.4 "Effective Date" means the receipt of requisite boards of
directors' approvals and expiration or earlier termination of any notice and
waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976,
as amended.

                  1.5 "EU" means each of the countries of the European Union (or
its successor), which currently include Austria, Belgium, United Kingdom,
Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg,
Netherlands, Portugal, Spain and Sweden, as such membership may change from time
to time, and includes countries upon their admission for full membership (with
commercial rights and privileges substantially comparable to those of the
foregoing countries); provided, however, that for purposes of this Agreement, if
a country is or becomes a member of the European Union (or its successor) at any
time during the Exclusive Period, such country shall be deemed to be included in
the EU even if such country in fact withdraws from or is otherwise no longer a
member of the European Union (or its successor).

                  1.6 "Exclusive Period" means the period commencing on the
Effective Date and continuing until the earlier of (i) the tenth anniversary of
the first commercial sale of the Product in the last country in the Major Market
in which the Product was introduced into commerce, or (ii) the fifteenth
anniversary of the Effective Date, unless terminated earlier in accordance with
Section 12.2 hereof.

                  1.7 "FDA" means the United States Food and Drug Administration
or any corresponding foreign drug registration governmental authority, or its
successor agency.

                  1.8 "ICN" means ICN Pharmaceuticals, Inc.

                  1.9 "ICN Facility" means the facility or facilities (which may
be a third party facility or facilities) used by ICN for the manufacture of the
Product to meet Schering's supply requirements under this Agreement.

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                  1.10 "ICN Trademark" means Virazole and any and all variations
thereof and/or substitute marks proposed, chosen, owned or controlled by ICN or
its Affiliates for use with the Product in the Territory.

                  1.11 "Improvements" means any change with respect to the
Product for use in the treatment of chronic hepatitis C, including without
limitation, any change in formulation, dosage or mode of delivery, any
additional indications and any change in the Product resulting from a change in
the manufacturing process.

                  1.12 "Know-How" means all ideas, inventions, data,
instructions, package inserts, promotional materials (after commercial launch),
know-how, processes, formulas, expert opinion and information (whether or not
patented or patentable), technology and other intellectual property (including
patents and any pending patent applications, but excluding the ICN Trademark)
owned or controlled by ICN and its Affiliates, or under which ICN and its
Affiliates have the right to grant sublicenses, on the Effective Date or during
the Exclusive Period, as all of the foregoing relate to the discovery, research,
development, manufacture, marketing, use or sale of Product for the treatment of
chronic hepatitis C, including, without limitation, all biological, chemical,
pharmacological, toxicological, pharmaceutical, physical and analytical,
clinical, safety, manufacturing and quality control data and information related
thereto, all correspondence with the FDA relating to the Product and all other
documents pertaining to communications with the FDA (including, but not limited
to, minutes of any FDA communications relating to the Product) and all
applications for Regulatory Approval.

                  1.13 "Labelling" means the bottle label, the package inserts
and the packaging for the Product sold in the Territory, including, where
applicable the Minimum Labelling.

                  1.14 "License Period" means the period commencing on the
Effective Date and continuing in perpetuity thereafter.

                  1.15 "Major Market" means each of France, Germany, Italy,
Spain, the United Kingdom, the United States and Japan.

                  1.16 [REDACTED]
                        (i) [REDACTED].
                       (ii) [REDACTED].

                  1.17 "NDA" means a New Drug Application, Product License
Application or its equivalent in the United States or any corresponding foreign
application, registration or certification for approval to market the Product,
including where applicable, applications for pricing, pricing reimbursement
approval and Labelling.

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                  1.18 "Net Sales" means, with respect to each country in the
Territory, the proceeds actually received by Schering or its Affiliates on all
sales of Product to an unaffiliated third party (whether an end-user, a
distributor or otherwise) including prelicense sales of the Product made prior
to Regulatory Approval, and exclusive of intercompany transfers or sales in the
Territory, less the reasonable and customary accrual-basis deductions from such
gross amounts including: (i) normal and customary trade, cash and quantity
discounts, allowances and credits; (ii) credits or allowances actually granted
for damaged goods, returns or rejections of Product and retroactive price
reductions; (iii) sales or similar taxes (including duties or other governmental
charges levied on, absorbed or otherwise imposed on the sale of Product
including, without limitation, value added taxes or other governmental charges
otherwise measured by the billing amount, when included in billing); (iv)
freight, postage, shipping, customs duties and insurance charges; (v) with
respect to sales outside the EU only, charge back payments and rebates granted
to managed health care organizations or to federal, state and local governments,
their agencies, and purchasers and reimbursers or to trade customers, including
but not limited to, wholesalers and chain and pharmacy buying groups; and (vi)
commissions paid to third parties other than sales personnel and sale
representatives or sales agents. For purposes of calculating Net Sales under
this Agreement, all sales of Product hereunder, whether made for cash or
otherwise, shall be deemed to be made for cash, at the applicable fair market
value of the Product.

                  In the event that Product is sold in the form of a combination
product containing one or more active ingredients other than ribavirin
("Combination Product"), Net Sales for such Combination Product will be
calculated by multiplying actual Net Sales of such Combination Product by the
fraction A/(A+B) where A is the invoice price of the Product if sold separately
by Schering, an Affiliate or sublicensee and containing ribavirin as the only
active ingredient and B is the invoice price of any other active component or
components in the Combination Product if sold separately by Schering, an
Affiliate or sublicensee. In the event that the Product is sold in the form of a
Combination Product containing one or more active ingredients other than
ribavirin and one or more such active ingredients of the Combination Product are
not sold separately, then the above formula shall be modified such that A shall
be the total cost to Schering, its Affiliate or sublicensee of the Product and B
shall be the total cost to Schering, its Affiliate or sublicensee of any other
active component or components in the combination.

                  1.19 "Product" means any oral product containing as its sole
active ingredient ribavirin and any Improvements thereto. The term "Product"
also shall include any pharmaceutical product for the treatment of chronic
hepatitis C containing oral ribavirin in combination with another active
ingredient; provided, however, that nothing in this Agreement shall be deemed to
grant to ICN any rights or license to recombinant interferon alfa 2b.

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                  1.20 "Product Price" has the meaning specified in Section 6.4
hereof.

                  1.21 "Product Specifications" means the general specifications
for the Product set forth as Exhibit B hereto, as such may be modified to
reflect an Improvement. The Product Specifications also shall be supplemented
and/or modified from time to time to the extent required by any regulatory
authority in the Territory with respect to obtaining or maintaining a Regulatory
Approval, and may otherwise be modified only by the written agreement of ICN and
Schering. The Product Specifications and any supplements or modifications
thereto shall be documented in such reasonable level of detail as is customary
in the pharmaceutical industry

                  1.22 "Regulatory Approval" means the technical, medical and
scientific licenses, registrations, authorizations and/or approvals of the
Product for the treatment of chronic hepatitis C in combination therapy with
recombinant interferon alfa 2b or as monotherapy and the marketing
authorizations based upon such approvals (including any prerequisite
manufacturing approvals or authorizations related thereto) that are required or
deemed necessary by any national, supra-national (e.g., the European Commission
or the Council of the European Union), regional, state or local regulatory
agency, department, bureau or other governmental entity in the Territory,
including the CPMP Opinion, if applicable, and any pricing, third party
reimbursement approvals and Labelling approvals as necessary for the
manufacture, distribution, use or sale of Product in a regulatory jurisdiction.

                  1.23 "Schering" means Schering-Plough Ltd.

                  1.24 "Schering Trademark" means any and all trademarks
proposed, chosen, owned or controlled by Schering or its Affiliates for use with
the Product in the Territory.

                  1.25 "Stock Purchase Agreement" means the Stock Purchase
Agreement, in the form attached hereto as Exhibit C, providing for the purchase
by Schering-Plough Corporation of certain common stock of ICN.

                  1.26 "Territory" means the entire world.

                                    ARTICLE 2

                           GRANT OF RIGHTS TO SCHERING

                  2.1 Grant of Exclusive License. Subject to the other
applicable terms and conditions of this Agreement, ICN hereby grants to
Schering, as of the Effective Date, (a) the exclusive licenses, exclusive even
with respect to ICN, to make, have made, develop, use, sell and distribute
Product for the treatment of chronic hepatitis C, in each

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country in the Territory during the Exclusive Period (1) under the Know-How and
(2) at Schering's option, under either the ICN Trademark or the Schering
Trademark, and (b) the non-exclusive license in and to the Know-How to enable
Schering to make, have made, develop, use, sell and distribute the Product for
the treatment of chronic hepatitis C in the Territory during the License Period.
The exclusive licenses granted in this Section 2.1 (i) are subject to the rights
of ICN retained by or reserved to ICN under this Agreement, including without
limitation, the rights to manufacture the Product and to distribute, market and
sell the Product as provided for in Section 7.1 hereof; (ii) do not include the
right to sublicense, except to Affiliates of Schering; (iii) shall prohibit ICN
from selling the Product for the treatment of chronic hepatitis C through any
distributorship agreements, marketing arrangements or similar agreements other
than those in effect on the Effective Date and set forth in Exhibit 2.1 hereto;
and (iv) shall prohibit ICN from selling ribavirin in bulk form to any third
parties (except pursuant to agreements relating to respiratory syncytial virus
and those agreements set forth on Exhibit 2.1).

                  2.2 Acceptance of Appointment. Subject to the other applicable
terms and conditions of this Agreement, Schering hereby accepts the granted
licenses and agrees to serve as ICN's exclusive licensee of the Product in the
Territory during the Exclusive Period (except for ICN's rights under Sections
2.1 and 7.1), and as ICN's non-exclusive licensee of the Product in the
Territory during the License Period, to sell the Product in accordance with the
terms of this Agreement.

                  2.3 ICN Retained Rights. During the License Period, ICN
retains all rights to the Product in the Territory that are not explicitly
granted to Schering under this Agreement. Without in any way limiting the
foregoing, ICN retains, both during and after the License Period, all rights in
the Territory for products owned or controlled by it other than the Product,
including, without limitation, the right to distribute, market and sell any such
other product in the Territory (e.g. lyophilized ribavirin, or cream, ointment
or liquid ribavirin). Except for such retained rights or as expressly provided
elsewhere in this Agreement, nothing in this Section 2.3 shall be deemed to
compromise or limit the exclusive license granted to Schering under Section 2.1.

                  2.4 Prices. During the Exclusive Period, Schering shall have
the sole authority to determine the price, payment terms, discounts, allowances
and other terms of sale extended by Schering to third party purchasers of the
Product in the Territory. Nothing in this Section 2.4 or elsewhere in this
Agreement shall be deemed to limit or restrict ICN in any way with respect to
its sole authority to determine the price, payment terms, discounts, allowances
and other terms of sale extended by ICN to third party purchasers of the Product
in the EU.

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                  2.5 Know-How. ICN shall furnish Schering promptly after the
Effective Date all Know-How which is necessary or useful to enable Schering to
exploit its rights under this Agreement. ICN shall promptly identify to Schering
and disclose to Schering, during the Exclusive Period, all additional Know-How,
which could relate to making, developing, using or selling Product licensed
hereunder, to which ICN or its Affiliates have or obtain rights, and such
Know-How shall be automatically deemed to be within the scope of the licenses
herein granted without payment of any additional compensation. ICN shall provide
reasonable technical assistance at no additional cost to enable Schering to
utilize such additional Know-How if Schering elects to do so; provided that
Schering shall promptly reimburse ICN for any out-of-pocket expenses incurred by
ICN in providing such assistance.

                  2.6 Approvals; Effective Date.

                  (a) Promptly after execution of this Agreement, the Parties
shall proceed diligently to make all appropriate filings under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), and to
proceed to obtain necessary approvals under HSR, including but not limited to
the expiration or earlier termination of any and all applicable waiting periods
required by the HSR. In addition the Parties shall proceed to obtain any other
authorizations, approvals and permits, if any, required for the consummation of
the transactions contemplated by this Agreement and the Stock Purchase
Agreement.

                  (b) If the Effective Date does not occur by December 15, 1995,
then either Party (or Schering-Plough Corporation, in the case of the Stock
Purchase Agreement) may terminate this Agreement and the Stock Purchase
Agreement on five day's notice to the other Party, in which event each such
agreement shall be terminated and all provisions of each such agreement shall be
of no further force or effect.

                                    ARTICLE 3

       CERTAIN DEVELOPMENT AND REGULATORY MATTERS DURING EXCLUSIVE PERIOD

                  3.1 Research and Development Activities.

                  (a) Following the Effective Date, Schering or its Affiliates
shall assume and incur all costs and expenses in connection with the research
and development activities which in its sole judgment are necessary to obtain
any CPMP Opinion or Regulatory Approval for the Product for the chronic
hepatitis C indication in the Territory. ICN shall supply Schering with all of
its requirements of Product for such research and development activities in
finished bulk capsules, and bulk substance as necessary for preclinical studies,
[ REDACTED ]. During the Exclusive Period, Schering shall also be responsible,
at its cost and expense, for all preclinical studies, pre-marketing and

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compassionate use programs, clinical trials, chemistry/pharmacy data, any post
approval studies required as a condition of obtaining any CPMP Opinion or
Regulatory Approval for the Product for the chronic hepatitis C indication in
the Territory, and any other information and data required as a condition of
obtaining any CPMP Opinion or Regulatory Approval for the Product for the
chronic hepatitis C indication in the Territory. The studies which Schering
intends to undertake, together with preliminary timetables and preliminary
budgets, are set forth in Exhibit D attached hereto and incorporated herein by
reference. Schering shall commence, within 45 days after the Effective Date, the
activities necessary to obtain Regulatory Approval in the EU, and shall
diligently pursue and conduct such activities as may be necessary in order to
obtain regulatory Approval for the Product for the chronic hepatitis C
indication in each country in the Territory, in accordance with Section 3.2.

                  (b) During the Exclusive Period, ICN shall assist Schering
from time to time, at Schering's reasonable request, in the design and
implementation of clinical studies, if Schering chooses, to undertake such
studies for a CPMP Opinion or Regulatory Approval for the chronic hepatitis C
indication for the Product. ICN shall assist Schering at Schering's reasonable
request, in the identification of clinical study sites in the Territory, the
recruitment of investigators, the review of study protocols and the monitoring
of the clinical studies (to the extent feasible in conjunction with ICN's own
scheduled monitoring for studies related to its other products, without the need
for additional resources). Schering shall reimburse ICN for its reasonable
out-of-pocket costs and expenses (equitably prorated, if applicable, for
monitoring expenses) incurred in rendering such assistance, unless otherwise
agreed by ICN. ICN shall invoice Schering for such expenses, and, upon request,
shall provide documentation for the invoice. The invoice shall be payable to ICN
or its designee(s) thirty (30) days after receipt by Schering of the invoice.

                  (c) During the Exclusive Period, Schering shall be responsible
for any quality of life, cost-benefit, cost-effectiveness, pharmacoeconomic and
any other studies (or portions of studies) necessary or desirable for pricing
and reimbursement approvals in the Territory, as well as any pre-marketing
studies prior to Regulatory Approval and post-marketing studies conducted
following a Regulatory Approval. ICN shall assist Schering from time to time, at
Schering's reasonable request, with incidental support in the conduct of the
studies.

                  (d) All data obtained by Schering or ICN which is reasonably
available to be reported from any activities conducted under Section 3.1(a), (b)
or (c) shall be jointly owned by the Parties, and Schering and ICN shall each
have the right to use all such data for all purposes contemplated or permitted
by this Agreement. Notwithstanding such joint ownership, any such data shall be
subject to the publication procedures set forth in

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Exhibit F. ICN will use its reasonable efforts to apply such procedures to any
studies that commenced prior to and are planned as of the Effective Date.

                  (e) Schering shall have the right to use for all purposes in
connection with obtaining Regulatory Approval for the Product in the Territory
for the treatment of chronic hepatitis C, all existing data relating thereto
owned, controlled or in the possession of ICN as of the Effective Date.

                  (f) The Parties recognize that ICN's development studies with
respect to other indications of the Product should not interfere with the
development activities conducted by Schering with respect to the chronic
hepatitis C indication. Accordingly:

                     (i)   ICN shall promptly disclose to Schering all studies
                           in progress and planned as of the Effective Date
                           relating to the Product in connection with any
                           hepatitis indications;

                     (ii)  If Schering determines in its reasonable business
                           judgment that the continuation of any such studies by
                           ICN would significantly interfere with Schering's
                           studies with respect to chronic hepatitis C, Schering
                           may require ICN to postpone such studies for so long
                           as is necessary such that ICN's continuation of its
                           studies would not interfere with Schering's studies,
                           but such postponement shall not be more than
                           [REDACTED];

                     (iii) If after the Effective Date ICN wishes to commence a
                           clinical development program for the Product for a
                           hepatitis indication other than the chronic hepatitis
                           C indication, then ICN shall consult with Schering
                           with respect to the possible joint development of
                           such indication. If Schering declines or does not
                           agree within 30 days to participate in such a joint
                           development program, then ICN shall be free to
                           continue such development. If Schering determines in
                           its reasonable business judgment that the
                           continuation of any such studies by ICN would
                           significantly interfere with Schering's studies with
                           respect to chronic hepatitis C, Schering may require
                           ICN to postpone such studies for so long as is
                           necessary such that ICN's continuation of its studies
                           would not interfere with Schering's studies, but such
                           postponement shall not be more than [REDACTED].

                  3.2 Product Registrations.

                  (a) Schering shall be responsible, at its cost and expense,
and in its sole judgment, for determining the appropriate regulatory strategy,
and for obtaining and

                                       9
<PAGE>   16
maintaining all Regulatory Approvals for the sale of the Product in the
Territory, except for costs and expenses to be borne by ICN with respect to its
own Regulatory Approval in the EU as provided in this Agreement. Schering shall
use its reasonable efforts to diligently obtain Regulatory Approvals with
Minimum Labelling within the Territory and in any event shall file for such
Regulatory Approvals in each country in the Major Market within nine months of
the completion of clinical trials and studies required in each such country for
Regulatory Approval, including any additional or supplemental clinical trials or
studies subsequently required by a regulatory authority for such Regulatory
Approval. For purposes of this Section 3.2, "completion of clinical trials"
shall in no event be deemed to occur sooner than the time of availability of the
integrated summary of safety reports and integrated summary of efficacy reports.
Schering shall use reasonable efforts to complete such reports promptly after
completion of treatment. With respect to countries in the Territory other than
the Major Market, Schering's efforts shall be commensurate with those efforts
used to pursue regulatory approval for its own products of similar potential,
value and status in such country or a comparable country in the Territory, as
the case may be, or, if Schering has no such similar products in a comparable
country, Schering's efforts shall be commensurate with the efforts that other
reputable pharmaceutical companies of comparable size and product portfolio
would use with respect to a product of similar potential, value and status in
such country. In connection with any health registration application of ICN
relating to the Product pending as of the Effective Date with the CPMP or FDA or
any successor to the CPMP or FDA, ICN shall, at Schering's request, provide to
Schering in a prompt manner, but in no event later than December 31, 1995,
responses to non-clinical questions which have been raised by the CPMP or FDA.
In addition, at the request of Schering, ICN shall provide to Schering
chemistry-pharmacy data and any other technical information which Schering may
reasonably require in order to obtain any CPMP Opinion or Regulatory Approval
for the Product in the Territory. At the request of Schering, ICN may agree to
continue its current efforts, and undertake where necessary and commercially
practicable additional efforts, including clinical trials in addition to those
already in progress, to maximize the opportunities of Schering to obtain
Regulatory Approval with Minimum Labelling in each country in the Territory at
the time of initial Regulatory Approval in such country, or as soon thereafter
as possible. All costs incurred by ICN in making such efforts shall be included
in the costs incurred in pursuing Regulatory Approval for purposes of Section
3.2(e). Notwithstanding the foregoing, ICN acknowledges that there can be no
assurance that Minimum Labelling will be obtained in any country in the
Territory. ICN shall advise and assist Schering, upon request, in the CPMP
process and the local registration process.

                  (b) Except as to the EU, each Regulatory Approval shall be
placed in Schering's name or the name of a designated Schering Affiliate unless
local law requires (whether because of the Product Labelling provisions of this
Agreement, pricing approval requirements, or otherwise), or ICN and Schering
otherwise agree, that a Regulatory

                                       10
<PAGE>   17
Approval be in the name of ICN or a designated ICN Affiliate. In such event,
Schering shall transfer the Regulatory Approval to ICN upon request at any time
that is commercially reasonable, or as soon thereafter as and to the extent
permitted by law. ICN agrees that notwithstanding such transfer of Regulatory
Approval from Schering to ICN, Schering shall retain the exclusive rights to
make, have made, develop, use, sell and distribute Product under the terms of
this Agreement.

                  (c) In the EU, the Parties shall each file applications for
Regulatory Approval in its own name and shall each be responsible for its own
filing fees. Schering shall use its reasonable efforts to provide ICN on a
timely basis with all reports, data, samples (if necessary), and, if
specifically requested by a regulatory authority, other information, necessary
to allow ICN to file for Regulatory Approval in the EU concurrently with
Schering.

                  (d) Prior to Regulatory Approval of the Product in each
country in the Territory, each Party shall promptly furnish to the other Party's
designated regulatory representative all data, and a copy of all material
correspondence and other material documents, received or sent to the FDA or a
regulatory authority in the Territory relevant to such Regulatory Approval.

                  (e) ICN shall reimburse Schering for [REDACTED], up to a
maximum amount of [REDACTED] to be reimbursed by ICN, of the reasonable costs
and expenses incurred by Schering in pursuing Regulatory Approval in the EU for
clinical and preclinical trials performed in the EU specifically required for EU
Regulatory Approval, and for regulatory costs required for EU Regulatory
Approval (other than each Party's filing fees, which shall be for the Parties'
respective accounts); provided, however, that such costs and expenses shall
exclude the cost of any studies performed in the EU or otherwise which are not
specifically required for EU Regulatory Approval. Schering shall invoice ICN
after the end of each calendar quarter commencing September 30, 1995, for ICN's
share of such costs and expenses, and shall provide ICN with a statement of such
costs and expenses, describing the costs and expenses in reasonable detail. If
ICN fails to pay any such invoice (or, in the event of a good faith dispute with
respect to such invoice, fails to pay the amount of the invoice into escrow in
accordance with the provisions of this Section 3.2(e)), by l7:00 Lucerne time on
the 90th day after the date on which it is received by ICN, then the royalties
that would otherwise be due to ICN for Net Sales of the Product in the EU shall
be permanently reduced to [REDACTED] of the amounts set forth in Article 6. If,
following such a failure to pay an invoice, ICN fails to pay a second invoice
(or, in the event of a good faith dispute with respect to such invoice, fails to
pay the amount of the invoice into escrow in accordance with the provisions of
this Section 3.2(e)), by 17:00 Lucerne time on the 90th day after the date on
which it is received by ICN, then at 17:00 Lucerne time on the 90th day day
after the date on which ICN received such second invoice, the rights granted to
Schering by this Agreement as to

                                       11
<PAGE>   18
the EU shall become exclusive, even as to ICN. In the event of a good faith
dispute as to any invoice rendered pursuant to this Section 3.2(e), ICN may
deposit the amount of the invoice with an independent third party escrow agent
mutually acceptable to the Parties, in an interest-bearing account, pending
resolution of such dispute. In such event, the Parties shall promptly negotiate
in good faith in an attempt to resolve any such dispute; provided, however, that
if the Parties are unable to resolve such dispute within 30 days after the date
on which payment of the invoice was due, such dispute shall be resolved in
accordance with the provisions of Article 13. Upon resolution of such dispute,
the interest, if any, earned on the amount held in escrow shall belong to the
Party entitled to receive the amount in escrow, appropriately allocated for any
allocation of the principal amount in escrow. ICN, through its independent
public accountants, shall have the right at reasonable times and on reasonable
notice to audit the books and records of Schering for the purpose of verifying
the costs and expenses charged to ICN under this Section 3.2(e) in accordance
with and subject to the procedures set forth in Section 6.10(a).

                  3.3 Pricing and Reimbursement Approvals.

                  (a) Schering shall be responsible for obtaining and
maintaining any pricing and reimbursement approvals required for the sale by
Schering of the Product in each country in the Territory. In the EU, ICN shall
be responsible for ICN's pricing and reimbursement approvals and structure.
Schering shall use its reasonable efforts to diligently obtain pricing and
reimbursement approvals for the Product in each country within the Territory
throughout the Exclusive Period, except as provided in the last sentence of
Section 4.1. Schering shall undertake reasonable efforts, including additional
studies of the type contemplated under Section 3.1(c), to diligently maximize
the opportunities to obtain commercially reasonable pricing for the Product in
each country in the Territory by the time of initial launch of the Product in
such country. Such efforts shall be commensurate with those efforts used for its
other products of similar potential, value and status in such country or, if
Schering has no comparable product in such country, a comparable country in the
Territory.

                  (b) Except as to the EU, each pricing and reimbursement
approval shall be placed in Schering's name or the name of a designated Schering
Affiliate unless local law requires, or ICN and Schering otherwise agree, that
such approval be in the name of ICN or a designated ICN Affiliate. In the EU,
pricing and reimbursement approvals shall be placed separately in the names of
ICN and Schering, or their respective designated Affiliates.

                  3.4 Failure to Obtain Approvals; Restrictions.

                  (a) If Schering does not file for Regulatory Approval in any
country or countries in the Major Market as required by Section 3.2(a), the
rights granted to Schering under this Agreement shall automatically terminate in
such country or countries. If Schering does not file for Regulatory Approval in
any country or countries in the

                                       12
<PAGE>   19
Territory (other than the Major Market) as required by Section 3.2(a), then ICN
at any time may notify Schering that ICN intends to pursue Regulatory Approval
in such country or countries within 90 days after the date of such notice by ICN
to Schering. Schering shall have the right, by giving notice to ICN within 30
days after receipt of such notice from ICN, to elect to pursue Regulatory
Approval in such country or countries; provided, however, that if Schering does
not file for Regulatory Approval in such country or countries as required by
Section 3.2 within 60 days after its notice to ICN, the rights granted to
Schering under this Agreement shall automatically terminate in such country or
countries. If Schering does not exercise its right to elect to pursue Regulatory
Approval as provided above, then ICN shall commence pursuing Regulatory Approval
in such country or countries within 90 days after the date of its notice to
Schering; if ICN does not do so, then the Parties shall have such rights as if
ICN did not provide an initial notice to Schering pursuant to this Section
3.4(a).

                  (b) If Schering at any time decides not to pursue Regulatory
Approval in any country or countries in the Territory, then Schering shall
notify ICN within 30 days of such decision. In such event, ICN at any time may
notify Schering that ICN intends to pursue Regulatory Approval in such country
or countries within 90 days after the date of such notice by ICN to Schering. If
ICN does not commence pursuing Regulatory Approval in such country or countries
within 90 days after the date of its notice to Schering, then the Parties shall
have such rights as if ICN did not provide an initial notice to Schering
pursuant to this Section 3.4(b).

                  3.5 Governmental Inspections. During the Exclusive Period,
each Party shall advise and provide a reasonable description to the other Party
of any governmental visits to, or written or oral inquiries about, any
facilities or procedures for the manufacture, storage or handling of Product,
promptly (but in no event later than five (5) calendar days) after such visit or
inquiry. Each Party shall furnish to the other Party, (a) within two (2) days
after receipt, any report or correspondence issued by the governmental authority
in connection with such visit or inquiry, including but not limited to, any FDA
Form 483 Establishment Inspection Reports, warning letters, and (b) at the same
it provides to a governmental authority, copies of any and all responses or
explanations relating to items set forth in Section 3.5(a), in each case purged
only of trade secrets of the receiving Party that are unrelated to the other
Party's activities under this Agreement and any information that is unrelated to
the Product.

                  3.6 Notice of Adverse Reactions. During the Exclusive Period,
either Party shall promptly report to the other Party any information regarding
adverse events related to the use of the Product in accordance with the Adverse
Event Reporting Procedures (as may be amended from time to time upon mutual
agreement) set forth as Exhibit E and incorporated herein by reference.

                                       13
<PAGE>   20
                  3.7 Recalls and Market Withdrawals.

                  (a) If at any time during the Exclusive Period (i) any
governmental or regulatory authority in the Territory issues a request,
directive, or order that the Product be recalled or withdrawn, or (ii) a court
of competent jurisdiction orders such a recall or withdrawal in the Territory,
or (iii) either Party determines in its sole discretion that the Product should
be recalled or withdrawn, the Parties shall take all appropriate corrective
actions. The final decision of a Party to recall pursuant to (iii) of this
subsection shall not be subject to arbitration under Article 13 of this
Agreement (or any other legal action, subject to Section 13(g)), although the
consequences to the other Party of any improper decision shall be subject to
arbitration.

                  (b) If the negligent act or omission by one Party or the
breach by one Party of an applicable product warranty (which, in the case of
Product manufactured by ICN shall be the warranty contained in Section 8.4(a))
is the proximate cause of a recall or withdrawal under any provision of Section
3.7(a), that Party shall be solely responsible for such costs and expenses for
its own account. If the negligent act or omission or breach of product warranty
by one Party is not the proximate cause of such a recall or withdrawal, (i) the
costs and expenses of notification and destruction or return of the recalled or
withdrawn Product in connection with a recall or withdrawal resulting from a
determination pursuant to Section 3.7(a)(iii), above shall be borne by the Party
making such determination, and (ii) the costs and expenses of notification and
destruction or return of the recalled or withdrawn Product in connection with a
recall or withdrawal pursuant to Section 3.7(a)(i) or (ii) shall be borne
equally by the Parties.

                  3.8 Additional Indications. In further recognition by the
Parties that ICN's development studies with respect to other indications of the
Product should not interfere with the development activities conducted by
Schering with respect to the chronic hepatitis C indication, if ICN pursues an
additional indication for the Product in any country in the Territory, then
(subject to compliance with Section 3.1(f) in the case of a hepatitis C
indication):

                     (i)   ICN may so notify Schering by providing Schering with
                           a description of ICN's development activities, all
                           associated preclinical and clinical data, ICN's
                           aggregate costs and expenses incurred in pursuing
                           such development activities to date, and the
                           estimated costs and expenses for remaining
                           activities, and such other information as Schering
                           may reasonably request. In such event, Schering shall
                           have the right, exercisable by notice to ICN given
                           not later than 75 days after receipt of the notice
                           from ICN, to elect to have such indication become
                           included in and subject to the terms and conditions
                           of this Agreement (including without limitation,

                                       14
<PAGE>   21
                           those relating to territory and royalties), and all
                           definitions shall be appropriately adjusted to
                           include such additional indication, effective upon
                           receipt by ICN of Regulatory Approval with respect to
                           such indication in any country in the Territory. If
                           Schering exercises such right, then (A) Schering
                           shall assume and be responsible for any and all
                           further development activities with respect to such
                           indication in accordance with the terms and
                           conditions of this Agreement, and (B) promptly after
                           receiving such Regulatory Approval, ICN shall notify
                           Schering of ICN's aggregate costs and expenses
                           incurred in pursuing Regulatory Approval for such
                           indication, and Schering shall reimburse ICN for such
                           costs and expenses within 45 days after receipt of an
                           invoice from ICN. Schering shall have the right to
                           audit such costs and expenses in accordance with the
                           provisions of Section 6.10(b).

                     (ii)  If ICN does not provide such notice to Schering or if
                           Schering declines to exercise such rights, then ICN
                           shall be free to pursue such indication without
                           further obligation to Schering, except as expressly
                           provided under this Agreement; provided, however,
                           that (i) ICN shall not sell the Product for any such
                           indication in any country in the Territory until five
                           years after the date of the first commercial sale in
                           such country by Schering of the Product for the
                           chronic hepatitis C indication, and (ii) ICN shall
                           not sublicense any third party to develop, make, have
                           made, use, sell or distribute the Product for such
                           indication in such countries and shall only sell the
                           Product in such countries directly or through its
                           direct or indirect subsidiaries, and only under the
                           brand name for the Product which ICN is then using
                           for the hepatitis C indication.

                  3.9 Improvements.

                  (a) Any Improvements relating to the Product made after the
Effective Date relating to the indication for chronic hepatitis C developed
during the Exclusive Period by or on behalf of a Party shall be deemed to be
included in the Product for all purposes under this Agreement. Without in any
way limiting the foregoing, each Party shall have the fully paid-up,
non-exclusive license to commercialize any such Improvements made by the other
Party during and after the Exclusive Period, in those countries of the Territory
where each Party has rights under this Agreement, subject to the other terms and
conditions of this Agreement; provided, however, if the non-exclusive licensee
breaches this Agreement, becomes insolvent or undergoes a change in control (as
defined in

                                       15
<PAGE>   22
Section 12.7) or Schering exercises its right under Section 12.2(a), no such
licenses to Improvements shall be granted.

                  (b) Any Improvements (other than those relating to the
indication for chronic hepatitis C) developed during the Exclusive Period by or
on behalf of a Party shall be owned by the Party or Parties whose employee(s),
contractee(s) or designee(s) would be deemed to be the inventor under U.S.
patent laws; provided, however, that (i) if Schering develops such an
Improvement then ICN shall have the right to commercialize any such Improvement
on such commercially reasonable terms as to which the Parties shall agree
following good faith negotiations, and (ii) if ICN develops such an Improvement
(other than an additional indication covered by Section 3.8) then Schering shall
have the right to commercialize any such Improvement for use in connection with
the treatment of hepatitis (other than hepatitis A and hepatitis B) on such
commercially reasonable terms as to which the Parties shall agree following good
faith negotiations.

                  (c) For the avoidance of doubt, ICN acknowledges that Schering
or its Affiliates are not granting any type of right or license to ICN under any
alpha-interferon patent rights or know-how owned, controlled or licensed to
Schering and its Affiliates.

                                    ARTICLE 4

                       CERTAIN OBLIGATIONS OF THE PARTIES
                             DURING EXCLUSIVE PERIOD

                  4.1 Diligence in Marketing the Product.

                  Schering agrees to make a commercial launch of Product in each
country within the Territory within six (6) months of obtaining Regulatory
Approval in each country (including, where applicable, pricing and third party
reimbursement approval). Schering shall use its reasonable efforts to diligently
promote, market and sell the Product in each country within the Territory
throughout the Exclusive Period. Such efforts shall be commensurate with those
efforts used to promote its own products of similar potential, value and status
in such country or a comparable country in the Territory, as the case may be,
or, if Schering has no such similar products in a comparable country,
commensurate with the efforts that other reputable pharmaceutical companies of
comparable size and product portfolio would use with respect to a product of
similar potential, value and status in such country. Both Parties recognize that
extenuating circumstances may arise that warrant a delay in launching the
Product, including but not limited to, unfavorable pricing, pricing
reimbursement or Labelling. The Parties agree that such circumstances shall be
considered in connection with excusing Schering from its obligation to launch
within the specified six (6) month period. Notwithstanding the foregoing,
however, Schering shall not be required to use reasonable efforts to diligently
launch, market or sell Product or pursue pricing and reimbursement approvals
under this Agreement in any country within

                                       16
<PAGE>   23
the Territory where a Regulatory Approval has been obtained that is less than
the Minimum Labelling for the Product. The Parties agree that if ICN makes a
commercial launch of the Product in any country of the EU prior to Schering
making such a launch in such country, and Schering has not made such launch
because of unfavorable pricing, pricing reimbursement or Labelling, then
Schering shall be relieved of its obligation to pay minimum royalties (as
described in Section 6.2) in all of the countries of the EU.

                  4.2 Compliance with Laws. During the Exclusive Period, each of
Schering and ICN shall comply with all material laws, rules and regulations
applicable to its respective activities under this Agreement.

                  4.3 Trademark Registrations and Infringements.

                  (a)      Notwithstanding the grant of rights to Schering under
                           Section 2.1, ICN acknowledges that Schering intends
                           to develop and use Schering Trademarks for the
                           Product in the Territory, and that Schering shall not
                           be required to use the ICN Trademark in connection
                           with the rights granted to Schering under this
                           Agreement and shall be free to use the Schering
                           Trademark, the use of the ICN Trademark being solely
                           at the election of Schering. Schering acknowledges
                           that ICN intends to use ICN Trademarks for the
                           Product in the EU, as provided in this Agreement.

                  (b)      Should Schering elect to use the ICN Trademark in any
                           country in the Territory, Schering shall notify ICN
                           in writing, and, if the ICN Trademark is filed or
                           registered there, ICN shall prosecute, maintain and
                           defend in its or an Affiliate's name, and at its own
                           cost and expense, the ICN Trademark in such country
                           relating to the marketing or sale of the Product. If
                           the ICN Trademark is not filed or registered in such
                           country, then ICN shall so notify Schering and, upon
                           Schering's written request, which shall not be
                           unreasonably refused, ICN shall file and prosecute
                           the ICN Trademark in such country, with the
                           reasonable out-of-pocket costs of ICN for such filing
                           and prosecution to be reimbursed to ICN by Schering.
                           In addition, Schering shall provide reasonable
                           cooperation to ICN so as to be entered as a
                           Registered User or recorded licensee of the ICN
                           Trademark in any country of the Territory, including
                           the execution of any documents pursuant to ICN's
                           reasonable request. Upon termination of this
                           Agreement for any reason, Schering shall also provide
                           reasonable cooperation to ICN, so as to be removed as
                           Registered User or recorded licensee of the ICN
                           Trademark in the Territory, including the execution
                           of any documents pursuant to

                                       17
<PAGE>   24
                           ICN's reasonable request, and this obligation shall
                           survive termination of this Agreement.

                  (c)      Schering and ICN each acknowledge the rights of the
                           other in their respective trademarks, trade names,
                           trade dress and logos used in connection with the
                           Product, and, except and to the extent expressly
                           provided in this Agreement, nothing in this Agreement
                           shall be deemed to give either Party during or after
                           the duration of this Agreement any right, title or
                           interest in the trademarks, trade names, trade dress
                           or logos of the other Party.

                  (d)      Neither Schering nor ICN shall use nor seek to
                           register any trademarks which are confusingly similar
                           to each others' respective trademarks, trade names,
                           trade dress or logos used in connection with the
                           Product, without the other Party's prior written
                           consent.

                  (e)      ICN agrees that, except for the rights retained by it
                           pursuant to this Agreement (including without
                           limitation, the rights to manufacture the Product and
                           to distribute, market and sell the Product in the EU
                           under the ICN Trademark), ICN shall neither use
                           itself, nor grant to a third party or to an
                           Affiliate, the right to the use of the ICN Trademark
                           in the Territory during the Exclusive Period for the
                           Product in any country where Schering has elected to
                           use the ICN Trademark as permitted by this Agreement
                           without the consent of Schering, which shall not be
                           unreasonably withheld.

                  (f)      Should Schering elect to use the ICN Trademark,
                           Schering shall submit to ICN, in writing, intended
                           formats for use on the ICN packaging and on
                           promotional and sales materials prior to the first
                           use thereof by Schering. Should ICN not provide a
                           reasonable basis for disapproval of the intended
                           formats within thirty (30) days of receipt, Schering
                           may then use the ICN Trademark in the formats
                           submitted on those and on subsequently developed
                           packaging and promotional materials. Schering agrees
                           that it will not thereafter implement any changes to
                           such formats unless the same has been submitted to
                           ICN in accordance with the procedure set forth in the
                           preceding sentence.

                  (g)      In any country of the Territory where Schering elects
                           to use the ICN Trademark, Schering shall notify ICN
                           promptly and in writing upon learning that the ICN
                           Trademark is actually or potentially infringed by a
                           third party, or if an allegation is made the ICN
                           Trademark may infringe the rights of a third party.
                           ICN shall be responsible for taking appropriate
                           action to stop the infringement or to defend the

                                       18
<PAGE>   25
                           right to the continued use of its trademark. Should
                           ICN decline to take action within thirty (30) days of
                           receipt of notice from Schering in a country of the
                           Territory where Schering has elected to use the ICN
                           Trademark, then Schering is not obligated to but may,
                           at its option, take reasonable action to stop the
                           infringement or to defend the right to the continued
                           use of the ICN Trademark. The Party bringing the
                           action shall be deemed the "Litigating Party" and the
                           other Party, the "Non-Litigating Party" for purposes
                           of this Section 4.3.

                  (h)      In any action brought pursuant to Section 4.3(g), the
                           costs of the action shall be borne and any recovery
                           shall be retained by the Litigating Party; provided,
                           however that if the Litigating Party recovers damages
                           attributable to (i) the profits of a third party
                           infringer; or (ii) lost profits or lost sales of the
                           Non-Litigating party; or (iii) punitive damages
                           against the third party infringer; then any net
                           recovery to the Litigating Party (i.e. total amount
                           of recovery, less court costs and attorneys' fees),
                           shall be divided equally between ICN and Schering. If
                           Schering is the Litigating Party in an action to
                           defend the right to the continued use of the ICN
                           Trademark and is successful in obtaining a final
                           judgment of a court of competent jurisdiction
                           defending the right to the continued use of the ICN
                           Trademark, then ICN shall reimburse Schering for half
                           of its reasonable out-of-pocket net costs in
                           obtaining the judgment (i. e. court costs and
                           reasonable attorneys' fees less any recoveries
                           received).

                  (i)      In any action brought pursuant to this Section 4.3,
                           the Non-Litigating Party shall provide reasonable
                           assistance and information to the Litigating Party
                           and shall be reimbursed for its reasonable
                           out-of-pocket costs and expenses.

                  (j)      Should for any reason the ICN Trademark, in any
                           country of the Territory where Schering has elected
                           to use it, or the Schering Trademark, in any country
                           of the Territory, be prevented from being used, then
                           the Parties shall consult as to a suitable other
                           trademark for use in connection with the Product for
                           purposes of this Agreement and in accordance with its
                           terms and conditions.

                  (k)      At the termination or expiration of the rights
                           granted by this Agreement or the Exclusive Period in
                           any country of the Territory for any reason, Schering
                           shall cease all use of the ICN Trademark, except for
                           any sell-off of Inventory of Product by Schering
                           following termination of this Agreement.

                                       19
<PAGE>   26
                                    ARTICLE 5

                              MARKETING ACTIVITIES

                  5.1 Establishment of Scientific and Commercial Liaison
Committees.

                  (a)      Promptly following the Effective Date, Schering and
                           ICN shall establish a Scientific Liaison Committee
                           and a Commercial Liaison Committee (the "Committees")
                           that shall be advisory committees only. Schering
                           shall promptly provide to the Committees material
                           data, reports and other information concerning
                           scientific and commercial matters relating to the
                           Product. Schering shall be the final decision-maker
                           as to the scope of the activities within the purview
                           of the Committees.

                  (b)      The activities set forth in Exhibit D, incorporated
                           herein by reference, among others, related to the
                           Product within the Territory during the Exclusive
                           Period shall be within the purview of the advisory
                           Scientific Liaison Committee. Notwithstanding the
                           foregoing, such activities, to the extent they relate
                           to the EU, shall not be within the purview of such
                           committee following Regulatory Approval in the EU.

                  (c)      The following activities, among others, related to
                           the Product within the Territory during the Exclusive
                           Period shall be within the purview of the advisory
                           Commercial Liaison Committee:

                           (i)      worldwide Product branding for promotional
                                    materials,

                           (ii)     consideration of positioning statements and
                                    detailing message for the Product for the
                                    Territory;

                           (iii)    planning market research and exchanging
                                    market research data;

                           (iv)     review of advertising and promotional
                                    materials;

                           (v)      coordination of international symposia and
                                    congresses;

                           (vi)     publication planning; and

                           (vii)    opinion leader development.

                           Notwithstanding the foregoing, such activities, to
                           the extent they relate to the EU, shall not be within
                           the purview of such committee following Regulatory
                           Approval in EU.

                  (d)      Schering shall be entitled to designate in writing to
                           ICN up to three (3) members of each Committee, and
                           ICN shall be entitled to designate in writing to
                           Schering up to three (3) members. A Party may change
                           its designated members at any time, upon written
                           notice

                                       20
<PAGE>   27
                           to the other Party. Each Party also shall be entitled
                           to bring a reasonable number of non-member attendees
                           to each meeting of the Committees. The chairs of the
                           Committees shall be designated by Schering during the
                           Exclusive Period.

                  (e)      The Committees shall meet from time to time, as
                           mutually agreed to by the members, but not fewer than
                           two times each calendar year during the Exclusive
                           Period, unless the members determine that fewer
                           meetings are required.

                  (f)      The chairs of the Committees shall designate the
                           location of the meetings of the Committees, but
                           unless ICN otherwise agrees, at least half of the
                           meetings shall take place in California. All travel,
                           lodging and similar expenses incurred by a member in
                           attending meetings of the Committees shall be borne
                           by the corresponding Party.

                  (g)      During the Exclusive Period, the members designated
                           by ICN and Schering shall be entitled to provide
                           input and comments with respect to the activities of
                           the Committees. It is understood that the Committees
                           are to serve as forums for information and input by
                           ICN as to the activities outlined in subsections (b)
                           and (c) above, but it is further understood that
                           Schering is not required to empower the Committees to
                           make final decisions as to such matters.

                  5.2 Product Labelling.

                  (a)      During the Exclusive Period, the Labelling shall, if
                           Schering elects to use the ICN Trademark, contain the
                           ICN Trademark and shall otherwise be consistent in
                           format (but not substance) with the Labelling for
                           Schering's other pharmaceutical products sold in the
                           corresponding country within the Territory at the
                           time in question. Unless prohibited by applicable
                           law, if Schering elects to use the ICN Trademark, the
                           Labelling shall indicate that the Product is under
                           license from ICN.

                  (b)      To the extent Schering elects to use the ICN
                           Trademark, Schering shall not change the Labelling in
                           format (but not substance) during the Exclusive
                           Period without the prior written authorization of ICN
                           (which shall not be unreasonably withheld), except
                           that ICN's consent is not required if Schering, at
                           its own cost and expense, desires to change the
                           colors and other elements of trade dress to conform
                           to the trade dress of Schering's other pharmaceutical
                           products, provided that such change does not affect
                           the other applicable Labelling requirements of this
                           Section 5.2.

                                       21
<PAGE>   28
                  5.3 Product Sampling.

                  (a)      Schering may provide sampling for the Product for use
                           in the treatment of chronic hepatitis C in a country
                           within the Territory, in reasonable quantities
                           comparable to the sampling conducted for its other
                           anti-viral and/or oncology products in that country;
                           provided, however, that subsequent to commercial
                           launch of the Product in any country, the amount of
                           such sampling in such country shall be limited to
                           [REDACTED]. The free use of Product prior to
                           commercial launch for the treatment of chronic
                           hepatitis C in (i) pre-marketing programs (where
                           permitted by applicable law) and compassionate
                           programs, and (ii) other marketing and Phase IV
                           studies, shall all be deemed sampling of the Product.
                           All samples of the Product shall be purchased at a
                           price equal to [REDACTED].

                  (b)      Subsequent to commercial launch of the Product by ICN
                           in any country, the amount of sampling in such
                           country by ICN shall be limited to [REDACTED]. If the
                           amount of such sampling by ICN in any such country
                           exceeds [REDACTED], then ICN shall pay to Schering an
                           amount equal to the [REDACTED], determined in
                           accordance with the provisions of Section 6.2.

                  (c)      The distribution of Product by Schering during the
                           [REDACTED] preceding the date on which Schering
                           reasonably expects to receive Regulatory Approval
                           shall be consistent with the Research and Development
                           Plan set forth as Exhibit D and with Schering's
                           previous historical compassionate use programs for
                           ribavirin in connection with the treatment of chronic
                           hepatitis C. Schering shall not engage in
                           pre-approval distribution of the Product (other than
                           for clinical trials, which are those with protocols
                           and case report forms) in a manner that could
                           reasonably be expected to compromise the distribution
                           by ICN of the Product in the EU following Regulatory
                           Approval.

                                    ARTICLE 6

                   COMPENSATION PAYABLE TO ICN; PAYMENT TERMS

                  6.1 License Fee. On the Effective Date, Schering shall pay ICN
a license fee in the amount of $23.0 million, by wire transfer of immediately
available funds to an account designated by ICN.

                                       22
<PAGE>   29
                  6.2 Royalty Payment. In partial consideration of the grant of
rights to Schering by ICN under this Agreement, Schering shall pay ICN a royalty
in the following amount:

                  (a)    with respect to sales of Product in the EU, [REDACTED]
                         of Net Sales, [REDACTED], but in no event less than
                         [REDACTED] of Net Sales; and

                  (b)    with respect to sales of Product in the Territory,
                         other than in the EU:
                                        [REDACTED];
                                        [REDACTED]; and
                                        [REDACTED];

provided, however, that in no event shall the royalty on sales of the Product in
any country in the Territory (including the EU) be less than [REDACTED] per
capsule sold based on a [REDACTED], [REDACTED] per capsule sold based on a
[REDACTED], and [REDACTED] sold based on a [REDACTED], such amounts to be
proportionately adjusted based on a scale of [REDACTED] for other capsule sizes
less than [REDACTED] and based on a scale of [REDACTED] for other capsule sizes
in excess of [REDACTED]; provided further, however, that if in any country in
the Territory ICN is also marketing the Product, and if at any time ICN's
current actual net selling price for the Product is less than [REDACTED] of
Schering's current actual net selling price for the Product (based on the same
capsule size and comparable terms and conditions, and other than due to
increases in price by Schering), then such minimum royalty shall no longer apply
to sales of the Product by Schering in such country (and such minimum royalty
shall not be reinstated). In the event any third party is also marketing oral
ribavirin in any country in the Territory, then Schering shall not be obligated
to pay the minimum royalty provided for in this Section 6.2 for that country.
[REDACTED] For purposes of this Section 6.2, the current actual net selling
price shall be determined on a country-by-country basis, for each calendar
quarter, by dividing the Net Sales of capsules of a particular capsule strength
by the total number of capsules of the same strength that were sold and sampled
in such country during such period. Each Party shall have the right to audit the
books and records of the other Party for the purpose of verifying the current
actual net selling price, in accordance with the procedures set forth in Section
6.10.

                  6.3 Royalty Reduction. The royalty payable by Schering
pursuant to this Agreement shall be reduced by [REDACTED] until the cumulative
royalty that would otherwise be payable but for such reduction equals [REDACTED]
million.

                  6.4 Product Price to Schering.

                  (a)      The price to be charged to Schering for supplies of
                           finished bulk Product furnished pursuant to Article
                           8, FOB ICN's plant, shall be

                                       23
<PAGE>   30
                           the greater of (i) [REDACTED] of Net Sales,
                           calculated on a country-by-country basis, or (ii)
                           ICN's Cost of Goods plus [REDACTED]. Schering shall
                           have the right to verify ICN's cost price of Product
                           pursuant to the procedures set forth in Section 6.10
                           hereof.

                  (b)      Schering shall establish an estimated sales price per
                           unit ("Estimated Selling Price") for the Product in
                           each country of the Territory. Schering agrees to
                           apply the same policy in establishing the Estimated
                           Selling Price for the Product as Schering would do in
                           the case of its own products of similar status.
                           Schering shall pay for all Product purchased under
                           this Agreement within 30 days after receipt of an
                           invoice from ICN, which shall be rendered upon
                           shipment, based on the Estimated Selling Price,
                           subject to adjustment for the final price as provided
                           in Section 6.4(e).

                  (c)      Schering may change its Estimated Selling Price on a
                           quarterly basis by notifying ICN at least fifteen
                           (15) days prior to the beginning of any calendar
                           quarter and such Estimated Selling Price shall then
                           apply for the calculation of the price at which
                           Schering shall purchase Product from ICN and all
                           orders of Product delivered to Schering in that
                           quarter shall be effected at said purchase price,
                           subject to adjustment for the final price as provided
                           in Section 6.4(e).

                  (d)      The price to be invoiced to Schering at time of
                           shipment for supplies of finished bulk Product shall
                           be equal to [REDACTED] of the Estimated Selling Price
                           of the Product in the Territory, plus relevant
                           customs duties, shipping, bulk packaging and
                           insurance costs, which shall be the responsibility of
                           and shall be duly paid by Schering.

                  (e)      Reconciliations of the price paid to ICN for Product
                           based on the Estimated Selling Prices as against
                           actual Net Sales (in order to arrive at the
                           [REDACTED] calculation of Net Sales), shall be made
                           by Schering on a quarterly basis within ninety (90)
                           days of the end of each calendar quarter.

                  6.5 Royalty Payment Dates. Within 60 days after the end of
each March, June, September and December in each and every calendar year during
the Exclusive Period, following the commencement of marketing of Product,
Schering shall furnish and deliver to ICN a full and true accounting of its
worldwide Net Sales of Product hereunder during the three (3) month period
ending with the previous March 31st, June 30th, September 30th and December 31st
and shall simultaneously pay to ICN, for the account of Schering or the
applicable Affiliate or sublicensee, as the case may be, a sum equal to the
aggregate of the royalty due thereon as calculated pursuant to Section

                                       24
<PAGE>   31
6.2 hereof (reconciled for any previous overpayments or underpayments), to such
account as ICN shall have designated from time to time in writing to Schering.

                  6.6 Direct Affiliate Licenses, Supporting Licenses and
Compulsory Royalties.

                  (a)      Whenever Schering shall reasonably demonstrate to ICN
                           that, in order to facilitate direct royalty payments
                           by an Affiliate, it is desirable that a separate
                           license agreement be entered into between ICN and
                           such Affiliate, ICN will grant such licenses directly
                           to such Affiliate by means of an agreement which
                           shall be consistent with all of the provisions
                           hereof, provided that Schering guarantees the
                           Affiliate's obligations thereunder or otherwise
                           provides to ICN assurances of performance
                           satisfactory to ICN in its sole discretion.

                  (b)      If Schering, its Affiliates or sublicensees are
                           legally obliged by any governmental authority in any
                           country in the Territory to grant licenses under the
                           Know-How to any third party to make, use, or sell
                           Product at royalty rates less than those payable
                           pursuant to this Agreement, then the royalty payable
                           prospectively hereunder with respect to Net Sales in
                           such country shall be reduced to such lesser rate as
                           long as such reduced royalty remains effective.

                  6.7 Place of Royalty Payment and Currency Conversions. All
royalties, with the exception of those payable on sales to customers in the
United States, shall be paid by Schering from its office in Lucerne,
Switzerland. Royalties payable on U.S. sales shall be paid directly to ICN by
Schering Corporation from its offices in Kenilworth, New Jersey. All royalty
payments shall be made in United States dollars to the extent that free
conversion to United States dollars is permitted. Royalties payable on sales in
countries other than the United States shall be calculated by multiplying the
appropriate royalty rate times the sales in each currency in which they are made
and converting the resulting amount into United States dollars at the rates of
exchange used by Schering for reporting such sales for United States financial
statement purposes. If, due to restrictions or prohibitions imposed by a
national or international authority, payments cannot be made as aforesaid, the
Parties shall consult with a view to finding a prompt and acceptable solution,
and Schering will, from time to time, deal with such monies as ICN may lawfully
direct at no additional out-of-pocket expense to Schering. Notwithstanding the
foregoing, if royalties cannot be remitted to ICN for any reason within six (6)
months after the end of the calendar quarter during which they are earned, then
Schering shall be obligated to deposit the royalties in a bank account in
Switzerland in the name of ICN. Royalties payable by Schering shall be net of
any foreign withholding taxes due, it being understood that such withholding
taxes are the obligation of ICN. Schering shall forward to ICN in a timely
manner all tax receipts relating to such withholding taxes.

                                       25
<PAGE>   32
                  6.8 Royalties on Resales. No earned royalty shall be payable
in respect of sales between and among Schering, its Affiliates and sublicensees,
it being understood that royalties are to be paid on resale of Product to
independent third parties.

                  6.9 Duration of Royalty Payments. With respect to Net Sales of
any Product in any country in the Territory, royalties shall be paid hereunder
with respect to Net Sales of such Product until [REDACTED] from the date of
first commercial sale after Regulatory Approval of such Product in such country,
but no longer than the duration of the Exclusive Period.

                  6.10 Maintenance of Royalty Records; Audit Rights.

                  (a)      Schering shall maintain and cause its Affiliates to
                           maintain books of account and adequate records of all
                           Net Sales of Product, including those made by
                           sublicensees. ICN shall have the right, following
                           written request by ICN, by its regularly employed
                           independent certified public accounting firm of
                           national standing, and at its own expense, during
                           normal business hours, to examine pertinent books and
                           records of Schering at all reasonable times (but no
                           later than forty-five (45) days after written request
                           is made and not more often than once each calendar
                           year) for the purpose of verifying and reporting to
                           ICN as to the computation of the royalty payments
                           made hereunder; it being understood that the right to
                           conduct such examination and the actual examination
                           with respect to any quarterly accounting period
                           hereunder shall take place not later than two (2)
                           years years following the expiration of said period.
                           Said accounting firm shall only report as to the
                           computation of the royalty payments made to ICN and
                           shall not disclose to ICN any other information. The
                           accounting firm representatives shall execute
                           customary confidential agreements prior to any
                           examination.

                  (b)      ICN shall maintain at a location in the United States
                           accurate books and records in accordance with
                           generally accepted accounting principles, in
                           sufficient detail to enable ICN's Cost of Goods
                           hereunder to be verified. All such records shall be
                           maintained for three (3) years after the submission
                           of each report required to be provided under this
                           Agreement. The independent certified public
                           accountant of Schering shall have access, subject to
                           a customary confidentiality agreement, during normal
                           business hours and following reasonable prior notice
                           to ICN, to the books and records of ICN to conduct a
                           review or audit thereof to verify the calculation of
                           ICN's Cost of Goods. Such access shall be available
                           not more than once each calendar year and for
                           eighteen (18) months after the

                                       26
<PAGE>   33
                           expiration or termination of this Agreement, but in
                           no event shall Schering be entitled to review or
                           audit ICN's Cost of Goods calculation occurring more
                           than three years before the requested date of the
                           review or audit.

                  (c)      If Schering manufactures Product pursuant to this
                           Agreement, then Schering shall maintain accurate
                           books and records in accordance with generally
                           accepted accounting principles, in sufficient detail
                           to enable Schering's Cost of Goods hereunder to be
                           verified. All such records shall be maintained for
                           three (3) years after the submission of each report
                           required to be provided under this Agreement. The
                           independent certified public accountant of ICN shall
                           have access, subject to a customary confidentiality
                           agreement, during normal business hours and following
                           reasonable prior notice to Schering, to the books and
                           records of Schering to conduct a review or audit
                           thereof to verify the calculation of Schering's Cost
                           of Goods. Such access shall be available not more
                           than once each calendar year and for eighteen (18)
                           months after the expiration or termination of this
                           Agreement, but in no event shall ICN be entitled to
                           review or audit Schering's Cost of Goods calculation
                           occurring more than three years before the requested
                           date of the review or audit.

                  (d)      Nothing in this Section 6.10 shall limit the rights
                           of any Party to obtain any and all relevant
                           information for purposes of an ADR (as defined in
                           Article 13) or otherwise pursuant to legal process in
                           the event of a dispute under this Agreement.

                  6.11 Equity Purchase. ICN and Schering-Plough Corporation are
contemporaneously with this Agreement entering into the Stock Purchase
Agreement.

                  6.12 Withholding Taxes, etc. If at any time during or after
the Agreement, any jurisdiction within the Territory requires that taxes be
withheld from any payment (or portion thereof) of ICN's compensation under this
Article 6, Schering may deduct such amount from the corresponding payment, or,
if applicable, ICN will promptly reimburse Schering or its designee(s) such
amounts. Schering shall provide ICN with documentation of such withholding and
payment in a manner that is satisfactory for purposes of the U.S. Internal
Revenue Service. Any withholdings paid when due hereunder shall be for the
account of ICN and shall not be included in the calculation of Net Sales. ICN
shall be liable for any deficiency, and any fine, assessment or penalty imposed
by any taxing authority in the Territory for any deficiency in the amount of any
such withholding or the failure to make such withholding payment; if Schering is
required to pay any such deficiency, or any fine, assessment or penalty for any
such deficiency, ICN shall promptly reimburse Schering for such payments, which
shall not be included in

                                       27
<PAGE>   34
the calculation of Net Sales. Notwithstanding the foregoing, in no event shall
ICN be liable for any deficiency, fine, assessment or penalty resulting from
Schering's failure to withhold the proper amount in accordance with the written
instructions of ICN to Schering given in accordance with Section 15.7 hereof.

                                    ARTICLE 7

                      ICN'S MARKETING RIGHTS; DISTRIBUTION

                  7.1 ICN's Marketing Rights. Notwithstanding the rights granted
to Schering under this Agreement, ICN shall have the right at any time following
ICN's receipt of Regulatory Approval in the EU to distribute, market, use and
sell the Product for the treatment of chronic hepatitis C, at ICN's expense, in
the EU; provided, however, that ICN shall not sell the Product to any entity in
the EU that could reasonably be expected to resell the Product outside the EU,
except for resales to non-EU countries that are members of the European Economic
Area. In addition, in recognition of ICN's current sales of the Product for the
treatment of chronic hepatitis C pursuant to a Regulatory Approval in Egypt, ICN
shall have the right under its existing contractual obligations (on a
semi-exclusive basis with Schering) at any time to distribute, market, use and
sell the Product for the treatment of chronic hepatitis C, at ICN's expense, in
Egypt; provided, however, that ICN shall not sell the Product to any entity in
Egypt that could reasonably be expected to resell the Product outside Egypt.

                  7.2 Distribution. In furtherance of the rights granted to
Schering to distribute Product throughout the Territory as and to the extent
provided in this Agreement:

                  (a)      Promptly after the Effective Date, ICN shall deliver
                           to Schering a report of sales of Product by ICN in
                           the Territory during each of the four most recently
                           ended fiscal quarters of ICN.

                  (b)      ICN shall provide to Schering a sales report on a
                           quarterly basis showing all sales and all units
                           shipped of Product by ICN in the Territory during the
                           preceding quarter.

                  (c)      As promptly as practicable following sales of the
                           Product to new customers by ICN, ICN shall provide to
                           Schering a report of such new customers for the
                           Product.

                  (d)      If, at any time, Schering determines, based on the
                           quarterly reports provided pursuant to Section
                           7.2(b), that there has been a significant change in
                           purchasing patterns by any customer or customers of
                           ICN, then Schering may require ICN to provide to
                           Schering, in advance of acceptance by ICN, all orders
                           from such customer or customers, and

                                       28
<PAGE>   35
                           Schering shall have the right to require ICN to
                           reject any such orders as to which Schering
                           reasonably concludes that the Product covered by such
                           orders are likely to be resold for use for chronic
                           hepatitis C outside the country from which the order
                           was placed. For purposes of this Section 7.2(d), a
                           "significant change in purchasing patterns" means
                           [REDACTED]. Schering shall not be entitled to require
                           ICN to reject any order as to which ICN reasonably
                           believes is justifiable in light of new indications,
                           changed labelling, outbreaks of disease or similar
                           circumstances.

                  (e)      ICN shall notify its existing distributors and
                           customers that it intends to restrict orders for
                           off-label and similar purposes.

                  (f)      If Schering has required ICN to provide it with all
                           orders prior to acceptance as provided above, then
                           ICN shall cause its independent auditors to certify
                           to Schering after the end of each calendar quarter,
                           that ICN has provided to Schering all such orders for
                           such quarter.

                  (g)      ICN's obligations under this Section 7.2 shall
                           terminate as to each country in the EU upon ICN's
                           receipt of Regulatory Approval in each such country
                           of the EU.

                  7.3 Ireland Sales. In furtherance of the rights granted to
Schering to distribute Product throughout the Territory as and to the extent
provided in this Agreement, ICN grants to Schering the right to, and Schering
shall, at its option, assume, perform or discontinue, and ICN shall cease, until
receipt by Schering of Regulatory Approval of the Product in the EU, the
distribution, marketing and sale of the Product currently being conducted by ICN
or any Affiliate of ICN in Ireland (including without limitation, any
obligations of ICN under distribution and other marketing agreements and
arrangements relating to Ireland). Schering shall pay to ICN, during each year
during the Exclusive Period (other than any year during the Exclusive Period
during which ICN actually sells the Product in Ireland, with the permission of
Schering) until receipt by Schering of Regulatory Approval of the Product in the
EU, an amount determined by [REDACTED] for sale of Product in Ireland in 1994,
[REDACTED], times [REDACTED], payable annually on January 10 of each year.
Schering shall have the right to audit the books and records of ICN once, within
[REDACTED] after the Effective Date, solely to verify such [REDACTED], and
otherwise in accordance with the provisions of Section 6.10(b).

                                       29
<PAGE>   36
                                    ARTICLE 8

                SUPPLY OF PRODUCT BY ICN DURING EXCLUSIVE PERIOD

                  8.1 Supply.

                  (a)      Subject to the provisions of Section 8.3, Schering
                           shall purchase the Product from ICN, and ICN shall
                           supply all of Schering's requirements of the Product
                           (including, but not limited to, research and
                           development requirements, including placebos, which
                           shall be in accordance with reasonable procedures for
                           ordering and production as agreed by the Parties) in
                           finished bulk capsules, or bulk substance as
                           necessary, subject to the terms and conditions of
                           this Article 8. If at any time ICN experiences a
                           shortage of Product supply and the available supplies
                           are not sufficient to satisfy all of Schering's
                           requirements for the Product in the Territory, ICN
                           shall allocate its available worldwide supplies
                           (including inventory in excess of customary supplies)
                           equitably among its own requirements and Schering's,
                           based on the purchasing history of such entities
                           during the prior six-month period.

                  (b)      For so long as ICN is supplying Product to Schering,
                           ICN shall furnish Schering with all information
                           related to the pre-approval inspections for the
                           Product and shall promptly resolve, at ICN's expense,
                           any manufacturing deficiencies in order to receive
                           timely Regulatory Approval. ICN shall thereafter be
                           solely responsible, at ICN's expense, for compliance
                           with current Good Manufacturing Practices as
                           determined by the FDA. ICN shall promptly address and
                           remedy any deficiencies noted in any Form 483 reports
                           or warning letters issued by the FDA.

                  8.2 Forecasts and Procedures.

                  (a)      Product will be supplied by ICN to Schering in
                           finished bulk capsules and only against receipt of
                           Schering's written purchase order and ICN's written
                           confirmation of the same. The delivery shall be
                           within [REDACTED] from the receipt of Schering's firm
                           purchase order if the quantity ordered does not
                           exceed the current forecast provided in accordance
                           with Section 8.2(b) by more than [REDACTED], and
                           within [REDACTED] if the ordered quantity exceeds the
                           current forecast by more than [REDACTED] but less
                           than [REDACTED]. The Parties shall discuss and
                           mutually agree on delivery schedules if the quantity
                           ordered exceeds the current forecast by more than
                           [REDACTED]. ICN shall within five days of receipt of
                           any Schering written purchase order confirm receipt
                           of

                                       30
<PAGE>   37
                           such purchase order (via facsimile to a facsimile
                           number supplied by Schering for this purpose).

                  (b)      To better enable ICN to plan its Product production
                           program for the Territory, Schering agrees to provide
                           ICN monthly its then current forecast for the
                           quantities of the Product that Schering will require
                           during the successive eighteen (18) months. Schering
                           shall break down each forecast indicating the
                           quantity and a requested delivery date by month for
                           the first successive twelve (12) months followed by
                           the next six (6) months indicated in two (2)
                           quarterly aggregates. Each monthly forecast issued
                           shall reflect a continuously rolling/progressive
                           eighteen (18) month cycle. Each current monthly
                           forecast shall be deemed to be a binding purchase
                           order. Schering shall purchase from ICN at least
                           [REDACTED] of the sum of its estimated Product orders
                           for the second calendar quarter indicated in the
                           latest forecast; provided, however, that if, for the
                           third and fourth calendar quarters indicated in such
                           monthly forecast, Schering does not purchase at least
                           [REDACTED] of the sum of its estimated Product
                           orders, Schering shall pay to ICN, at the time of
                           payment for Product purchased for such quarters, an
                           amount equal to ICN's carrying cost (including
                           warehousing, finance costs and similar items) of the
                           amount of inventory (including bulk substance and
                           finished capsules) reflected in such estimated
                           Product orders in excess of the amount of Product
                           purchased for such quarters. ICN shall not be under
                           any obligation to accept any order of the Product
                           which is in excess of [REDACTED] of the latest
                           forecast relating to Schering's requirement for the
                           first twelve (12) months.

                  (c)      Schering shall place orders in increments of single
                           batches equivalent to [REDACTED]; provided, however,
                           that solely for purposes of clinical trials the
                           minimum batch size shall be [REDACTED]. ICN will use
                           reasonable efforts to provide capsules having the
                           longest available shelf life for purposes of such
                           clinical trials.

                  (d)      ICN may reject Schering's purchase order if the
                           purchase order fails to substantially comply with the
                           requirements of this Article 8. In the event of any
                           discrepancy between a purchase order for the Product
                           and this Agreement, the terms of this Agreement shall
                           govern. ICN shall use commercially reasonable efforts
                           to meet any Product requirements of Schering.

                                       31
<PAGE>   38
                  (e)      All Product shall be packed for air freight shipment
                           and storage in accordance with Schering's
                           specifications as mutually agreed upon and in
                           accordance with applicable laws and regulations.

                  (f)      Schering shall be responsible for the costs,
                           including customs duties, freight and insurance, that
                           may be required to ship the Product from ICN's plant
                           to any destination.

                  (g)      Risk of loss and damage to the Product shall pass to
                           Schering upon tender of the Product at ICN's plant.

                  (h)      ICN shall prepare, obtain, and transmit to Schering
                           such documents as shall be required for Schering to
                           take over customs clearance and to satisfy other
                           import formalities into the Territory. Schering shall
                           use diligent efforts to promptly clear shipments of
                           Product through customs and shall handle and store
                           the Product thereafter in a manner which maintains
                           the integrity of the Product.

                  (i)      At the reasonable request of Schering at any time
                           during the Exclusive Period, ICN shall promptly enter
                           into a written supply agreement for supply of Product
                           to a Schering Affiliate (located within the
                           Territory) designated by Schering on terms and
                           conditions consistent with those contained in this
                           Agreement as well as any additional terms as may be
                           required by applicable law and any customary
                           additional terms as shall be agreed to by the Parties
                           (such consent not to be unreasonably withheld). If
                           there is any inconsistency between this Agreement and
                           such supply agreement, the terms of this Agreement
                           shall control.

                  (j)      ICN shall provide to Schering, at the commencement of
                           Schering's purchases of Product from ICN, and shall
                           update from time to time, the test methodologies used
                           by ICN in preparing the certificates of analysis
                           referred to in Section 8.4, and any differences
                           between the then-current specifications for the
                           Product and the Product Specifications.

                  8.3 Schering's Right to Manufacture.

                  (a)      Within 24 months after the Effective Date, Schering
                           shall notify ICN as to whether Schering elects to
                           continue to purchase Product from ICN or to
                           discontinue all or, if agreed to by ICN, a part of
                           Schering's purchase of Product from ICN, and to
                           manufacture Product itself or have Product
                           manufactured for it by a third party. If Schering
                           elects to continue to purchase Product from ICN, then
                           the Parties shall negotiate in good faith as to any
                           capacity requirements, and the cost of any related
                           capital investment, required to meet Schering's
                           requirements. Subject to agreement of the Parties as
                           to such matters,

                                       32
<PAGE>   39
                           from the Effective Date, ICN shall only be required
                           to supply Schering to the extent of ICN's current
                           available capacity, taking into account ICN's own
                           requirements and commitments with respect to Product.
                           ICN represents that ICN has adequate capacity to
                           supply Schering's requirements of Product for
                           clinical programs for Regulatory Approval. If, after
                           deciding to manufacture or have manufactured the
                           Product, Schering wishes to again purchase Product
                           from ICN, Schering shall give ICN not less than 6
                           months' notice. ICN may, but shall not be required
                           to, supply Product to Schering, on such terms to
                           which the Parties may agree.

                  (b)      In the event that Schering elects to manufacture
                           Product itself or have Product manufactured for it by
                           a third party, then so long as this Agreement remains
                           in effect, Schering shall, at the request of ICN,
                           supply Product to ICN at a price and on other terms
                           and conditions consistent with the terms and
                           conditions on which ICN supplies Product to Schering
                           under this Agreement. Schering shall only be required
                           to supply ICN to the extent of Schering's available
                           capacity, taking into account Schering's own
                           requirements and commitments with respect to Product.
                           For so long as Schering is supplying Product to ICN,
                           Schering shall furnish ICN with all information
                           related to the pre-approval inspections for the
                           Product and shall promptly resolve, at Schering's
                           expense, any manufacturing deficiencies in order to
                           receive timely Regulatory Approval. Schering shall
                           thereafter be solely responsible, at Schering's
                           expense, for compliance with current Good
                           Manufacturing Practices as determined by the FDA.
                           Schering shall promptly address and remedy any
                           deficiencies noted in any Form 483 reports or warning
                           letters issued by the FDA.

                  (c)      If Schering elects to purchase Product from ICN, ICN
                           shall maintain its production facilities (including
                           those of any third party supplier) used to
                           manufacture the Product, so as to permit the
                           importation and supply of Product in a timely manner
                           under this Agreement in all applicable countries in
                           the Territory. So long as Schering is purchasing
                           Product from ICN, ICN will permit Schering
                           representatives to inspect the Product-related
                           portion of its production facilities, at Schering's
                           cost and expense, at any time during normal business
                           hours and upon reasonable prior notice. Any such
                           inspection that involves third party facilities shall
                           be subject to such limitations (including
                           confidentiality obligations) as may be imposed under
                           the applicable agreement between ICN and the third
                           party.

                                       33
<PAGE>   40
                  8.4 Limited Warranty.

                  (a)      ICN warrants that each shipment of the Product
                           supplied to Schering pursuant to this Agreement, when
                           shipped from the ICN Facility, shall conform to the
                           Product Specifications, shall be manufactured by ICN
                           and supplied to Schering in accordance with the
                           requirements of applicable law in the country of
                           manufacture and any other applicable regulatory legal
                           requirements in the Territory, including, without
                           limitation, any current Good Manufacturing Practices
                           requirements, and shall be of substantially
                           equivalent quality as the Product produced by ICN for
                           its own use. ICN shall provide to Schering
                           concurrently with each shipment of Product a
                           Certificate of Analysis which contains analytical
                           results and specifications of the batch. THE WARRANTY
                           PROVIDED FOR IN THIS SECTION 8.4(a) IS EXCLUSIVE AND
                           IN LIEU OF ALL OTHER WARRANTIES, EXPRESS OR IMPLIED,
                           INCLUDING WARRANTIES OF MERCHANTABILITY AND FITNESS
                           FOR A PARTICULAR PURPOSE, WHETHER PERTAINING TO THE
                           PRODUCT AND WHETHER ARISING BY LAW, CUSTOM, CONDUCT,
                           OR USAGE OR TRADE, AND THE RIGHTS AND REMEDIES
                           PROVIDED IN SECTION 8.4(b) ARE EXCLUSIVE AND IN LIEU
                           OF ALL OTHER RIGHTS AND REMEDIES (EXCEPT AS PROVIDED
                           IN SECTION 8.4(d)).

                  (b)      Subject to Section 3.7(b) if any Product is shown to
                           be in breach of ICN's warranty ("Non-Conforming
                           Product") contained in Section 8.4(a), Schering's
                           exclusive remedy shall be to return to ICN the
                           Non-Conforming Product and to receive a credit (with
                           ICN paying related transportation costs) in the
                           amount paid to ICN hereunder for such Non-Conforming
                           Product and related transportation costs (including
                           costs of returning such Non-Conforming Product) or to
                           have ICN replace such Non-Conforming Product.

                  (c)      EXCEPT FOR ICN'S OBLIGATION TO REFUND OR REPLACE
                           NON-CONFORMING PRODUCT AS SET FORTH IN SECTION 8.4(b)
                           ABOVE, ICN SHALL NOT BE LIABLE TO SCHERING FOR, AND
                           SCHERING WAIVES ANY AND ALL CLAIMS AGAINST ICN FOR,
                           ALL DAMAGES, INCLUDING SPECIAL, INDIRECT,
                           CONSEQUENTIAL OR INCIDENTAL DAMAGES, WHICH MAY BE
                           CAUSED BY, OR IN ANY WAY RESULT FROM, THE PRODUCT OR
                           THEIR DELIVERY UNDER THIS AGREEMENT, INCLUDING
                           DAMAGES RESULTING FROM DELAYS IN DELIVERY, OR FAILURE
                           TO DELIVER, ANY

                                       34
<PAGE>   41
                           PRODUCT WHETHER BASED ON BREACH OF WARRANTY, STRICT
                           LIABILITY OR ANY OTHER CAUSE OF ACTION.

                  (d)      NOTHING IN THIS SECTION SHALL BE DEEMED IN ANY WAY TO
                           LIMIT SCHERING'S RIGHTS OF INDEMNIFICATION PURSUANT
                           TO SECTIONS 11.2(a)(ii) AND 11.2(b)

                  8.5 Rejection of Product.

                  (a)      Schering may reject any shipment of Product from ICN
                           that does not meet ICN's warranty set forth in
                           Section 8.4, upon notice to ICN delivered within
                           forty five (45) days after receipt by Schering of
                           such shipment or, in the case of any latent defect,
                           after Schering discovered or had a reasonable basis
                           for discovering such defect. Any shipment of Product
                           that is not rejected by Schering within such period
                           shall be deemed accepted. In no event shall ICN be
                           liable for any nonconformity of the Product resulting
                           from the shipment, storage or handling of the Product
                           after tender by ICN in accordance with Section 8.2(g)
                           (unless resulting from the fault of ICN, such as not
                           shipping in accordance with agreed specifications),
                           or the tampering, alteration or mishandling of the
                           Product by any person (including any customer of
                           Schering) following such tender.

                  (b)      Upon the request of ICN, Schering shall furnish
                           evidence of nonconformity of the shipment of Product.
                           If ICN confirms the nonconformity, ICN will use
                           diligent efforts to, at Schering's request, either
                           promptly replace the Product at no additional charge
                           to Schering with a conforming shipment (which may
                           include rework of the Product if feasible), or issue
                           a credit to Schering (pro rated, if less than a full
                           shipment is rejected) for the Product Price and any
                           other costs and expenses incurred by Schering in
                           shipping the rejected Product to ICN. If ICN
                           disagrees with Schering's determination, the Parties
                           shall promptly submit the dispute to a mutually
                           acceptable laboratory for a binding determination (in
                           lieu of the procedures described in Article 13) of
                           the conformance or nonconformity of the Product and
                           ICN shall submit as part of its documentation
                           retained manufacturing samples. The non-prevailing
                           Party shall pay the costs and expenses of the
                           laboratory tests.

                                    ARTICLE 9

                                 CONFIDENTIALITY

                  9.1 Confidentiality. ICN and Schering shall use only in
accordance with this Agreement and shall not disclose to any third party any
confidential or proprietary

                                       35
<PAGE>   42
information, whether patentable or not, related to the subject matter of this
Agreement furnished by the other Party pursuant to this Agreement or otherwise,
without the prior written consent of the other Party. The foregoing obligations
shall survive the expiration or termination of this Agreement for a period of
twenty (20) years. These obligations shall not apply to:

                  (a)      Information that is known to the receiving Party
                           prior to the time of disclosure, to the extent
                           evidenced by written records of the receiving Party;

                  (b)      Information disclosed to the receiving Party by a
                           third party which has a right to make such
                           disclosure;

                  (c)      Information that is at the time of disclosure or
                           thereafter becomes published or otherwise part of the
                           public domain without breach of this Agreement by the
                           receiving Party;

                  (d)      Information which is independently developed by
                           employees of the receiving Party or its Affiliates
                           and such independent development can be properly
                           demonstrated by the receiving Party; or

                  (e)      Information that is required to be disclosed by law,
                           regulation, rule, act or order of the FDA or similar
                           authority or agency or a court of competent
                           jurisdiction; provided that the receiving Party gives
                           the other Party sufficient advance notice to permit
                           it to seek a protective order or other similar order
                           with respect to such information and thereafter
                           discloses only the minimum information required to be
                           disclosed in order to comply with the request,
                           whether or not a protective order or other similar
                           order is obtained by the other Party.

                  9.2 No Publicity. A Party may not use the name of the other
Party in any publicity or advertising and, except as provided in section 9.1,
may not issue a press release or otherwise publicize or disclose any information
related to this Agreement or the terms or conditions hereof, without the prior
written consent of the other Party. The Parties shall agree on a form of initial
press release that may be used by either Party to describe this Agreement.
Nothing in the foregoing, however, shall prohibit a Party from making such
disclosures to the extent deemed necessary under applicable federal or state
securities laws or any rule or regulation of any nationally recognized
securities exchange; in such event, however, the disclosing Party shall use good
faith efforts to consult with the other Party prior to such disclosure and,
where applicable, shall request confidential treatment to the extent available.

                                       36
<PAGE>   43
                                   ARTICLE 10

                         REPRESENTATIONS AND WARRANTIES

                  10.1 Representations and Warranties of Each Party. Each of ICN
and Schering hereby represents, warrants and covenants to the other Party hereto
as follows:

                  (a)      It is a corporation duly organized and validly
                           existing under the laws of the state or other
                           jurisdiction of incorporation or formation;

                  (b)      The execution, delivery and performance of this
                           Agreement by such Party has been duly authorized by
                           all requisite corporate action, subject only to
                           receipt of requisite boards of directors' approvals;

                  (c)      It has the power and authority to execute and deliver
                           this Agreement and to perform its obligations
                           hereunder;

                  (d)      The execution, delivery and performance by such Party
                           of this Agreement and its compliance with the terms
                           and provisions hereof does not and will not conflict
                           with or result in a breach of any of the terms and
                           provisions of or constitute a default under (i) a
                           loan agreement, guaranty, financing agreement,
                           agreement affecting a product or other agreement or
                           instrument binding or affecting it or its property;
                           (ii) the provisions of its charter documents or
                           bylaws; or (iii) any order, writ, injunction or
                           decree of any court or governmental authority entered
                           against it or by which any of its property is bound;

                  (e)      Except for the governmental and regulatory approvals
                           required to market the Product in the Territory, the
                           execution, delivery and performance of this Agreement
                           by such Party does not require the consent, approval
                           or authorization of, or notice, declaration, filing
                           or registration with, any governmental or regulatory
                           authority and the execution, delivery or performance
                           of this Agreement will not violate any law, rule or
                           regulation applicable to such Party;

                  (f)      This Agreement has been duly authorized, executed and
                           delivered and constitutes such Party's legal, valid
                           and binding obligation enforceable against it in
                           accordance with its terms subject, as to enforcement,
                           to bankruptcy, insolvency, reorganization and other
                           laws of general applicability relating to or
                           affecting creditors' rights and to the availability
                           of particular remedies under general equity
                           principles; and

                  (g)      It shall comply with all applicable material laws and
                           regulations relating to its activities under this
                           Agreement.

                                       37
<PAGE>   44
                  10.2 ICN'S Representations. ICN hereby represents, warrants
and covenants to Schering as follows:

                  (a)      ICN owns or has sufficient rights in and to the
                           Know-How and ICN Trademark, free and clear of any
                           liens or encumbrances, to grant the rights to
                           Schering as contained in this Agreement;

                  (b)      ICN is not aware of any existing third party
                           trademark, trade name or other intellectual property
                           rights in the Territory that might be infringed by
                           the import, distribution, marketing, use or sale of
                           the Product in the Territory under the ICN Trademark
                           or through the use of the ICN name;

                  (c)      During the Exclusive Period, ICN will use diligent
                           efforts not to diminish the right under its Know-How
                           and ICN Trademark granted to Schering hereunder,
                           including without limitation by not committing or
                           permitting any acts or omissions which would cause
                           the breach of any agreements between itself and third
                           parties which provide for intellectual property
                           rights applicable to the development, manufacture,
                           use or sale of Product. ICN agrees to provide
                           Schering promptly with notice of any such alleged
                           breach. ICN is in compliance in all material respects
                           with any such agreements with third parties;

                  (d)      Data summaries provided to Schering by ICN prior to
                           the Effective Date relating to the clinical trials of
                           the Product, taken as a whole, accurately represent
                           the underlying raw data;

                  (e)      ICN has provided to Schering a summary of all adverse
                           events known to ICN relating to the Product;

                  (f)      ICN has disclosed to Schering all information known
                           to ICN concerning (i) patents owned by third parties
                           that might be infringed by Schering's use of the
                           Product to treat chronic hepatitis C; or (ii) patent
                           applications owned, or reasonably believed by ICN to
                           be owned, by third parties that, if issued as a
                           patent, might be infringed by Schering's use of the
                           Product to treat chronic hepatitis C;

                  (g)      ICN has no knowledge of any circumstances that (i)
                           would adversely affect the commercial utility of the
                           use of the Product to treat chronic hepatitis C; or
                           (ii) that would render Schering liable to a third
                           party for patent infringement as a consequence of
                           Schering's use of the Product to treat chronic
                           hepatitis C; and

                  (h)      (i) ICN has disclosed to Schering all distributorship
                           agreements, marketing arrangements or similar
                           agreements whereby ICN is

                                       38
<PAGE>   45
                           selling, distributing or supplying the Product
                           (including directly or through Affiliates of ICN) or
                           whereby ICN has authorized third parties to make,
                           sell, distribute or supply the Product (collectively
                           "License Agreements"); (ii) Exhibit 2.1 sets forth a
                           list of all License Agreements; (iii) no contract,
                           agreement or understanding, either oral or in
                           writing, modifies, amends or supplements the License
                           Agreements; and (iv) ICN shall not enter into any
                           License Agreements between the date hereof and the
                           Effective Date.

                  (i)      Except as set forth in Exhibit 2.1, ICN has not
                           granted any rights under the Know-How to any third
                           party to either make, sell, distribute or supply the
                           Product.

                  (j)      As soon as practicable following the Effective Date,
                           ICN shall at its sole cost and expense (A) terminate
                           (and not renew, where applicable), or allow to
                           expire, the License Agreements listed on Exhibit
                           2.1(A); (B) terminate (by agreement with the other
                           Party thereto, or otherwise) the License Agreements
                           listed on Exhibit 2.1(B); and (C) use reasonable
                           efforts to amend the License Agreements listed on
                           Exhibit 2.1(C) to prohibit the other party from
                           making, selling, distributing or supplying any oral
                           formulation of the Product in the Territory in
                           derogation of Schering's rights under this Agreement.
                           Except as previously disclosed to Schering or as
                           contemplated by Article 7, Article 8 or this Section
                           10.2(j), during the Exclusive Period, ICN shall not
                           distribute, market, sell or supply the Product
                           (including directly or through Affiliates of ICN) in
                           any country in the Territory.

                  (k)      Neither ICN nor any officer of ICN or Affiliate of
                           such officer is currently engaged in any research or
                           development programs for any other products for the
                           treatment of hepatitis C (including directly or
                           through Affiliates of ICN).

                  10.3 Continuing Representations. The representations and
warranties of each Party contained in Sections 10.1 and 10.2 shall survive the
execution of this Agreement and shall remain true and correct after the date
hereof with the same effect as if made as of the date hereof.

                  10.4 No Inconsistent Agreements. Neither Party has in effect
and after the Effective Date neither Party shall enter into any oral or written
agreement or arrangement that would be inconsistent with its obligations under
this Agreement.

                                       39
<PAGE>   46
                                   ARTICLE 11

                   INDEMNIFICATION AND LIMITATION ON LIABILITY

                  11.1 Indemnification by Schering.

                  (a)      Schering shall indemnify, defend and hold harmless
                           ICN and its Affiliates, and each of its and their
                           respective employees, officers, directors and agents
                           (each, a "ICN Indemnified Party") from and against
                           any and all liability, loss, damage, cost, and
                           expense (including reasonable attorneys' fees),
                           subject to the limitations in section 11.5
                           (collectively, a "Liability") which the ICN
                           Indemnified Party may incur, suffer or be required to
                           pay resulting from or arising in connection with (i)
                           the breach by Schering of any covenant,
                           representation or warranty contained in this
                           Agreement, (ii) any negligent act or omission or
                           willful misconduct of Schering (or any Affiliate
                           thereof) in the promotion, marketing and sale of the
                           Product or any other activity conducted by Schering
                           under this Agreement which is the proximate cause of
                           injury, death or property damage to a third party, or
                           (iii) the successful enforcement by an ICN
                           Indemnified Party of any of the foregoing.

                  (b)      Schering also shall indemnify, defend and hold
                           harmless each ICN Indemnified Party from and against
                           any Liability which the ICN Indemnified Party may
                           incur, suffer or be required to pay resulting from or
                           arising in connection with any negligent act or
                           omission or willful misconduct of Schering (or any
                           Affiliate thereof) in the manufacture, promotion or
                           marketing of the Product or any other activity
                           conducted by Schering under this Agreement after the
                           Exclusive Period which is the proximate cause of
                           injury, death or property damage to a third party.

                  11.2 Indemnification by ICN.

                  (a)      ICN shall indemnify, defend and hold harmless
                           Schering and its Affiliates, and each of its and
                           their respective employees, officers, directors and
                           agents (each, an "Schering Indemnified Party") from
                           and against any Liability which the Schering
                           Indemnified Party may incur, suffer or be required to
                           pay resulting from or arising in connection with (i)
                           the breach by ICN of any covenant, representation or
                           warranty contained in this Agreement, (ii) any
                           negligent act or omission or willful misconduct of
                           ICN (or any Affiliate thereof) in providing the
                           Know-How or in the manufacture, promotion, marketing
                           or sale of the Product or any other activity
                           conducted by ICN under this Agreement which is the
                           proximate

                                       40
<PAGE>   47
                           cause of injury, death or property damage to a third
                           party, or (iii) the successful enforcement by an
                           Schering Indemnified Party of any of the foregoing.
                  (b)      ICN also shall indemnify, defend and hold harmless
                           each Schering Indemnified Party from and against any
                           Liability which the Schering Indemnified Party may
                           incur, suffer or be required to pay resulting from or
                           arising in connection with any negligent act or
                           omission or willful misconduct of ICN (or any
                           Affiliate thereof) in the manufacture, promotion or
                           marketing of the Product or any other activity
                           conducted by ICN under this Agreement after the
                           Exclusive Period which is the proximate cause of
                           injury, death or property damage to a third party.

                  11.3 Conditions to Indemnification. The obligations of the
indemnifying Party under paragraphs 11.1 and 11.2 are conditioned upon the
delivery of written notice to the indemnifying Party of any potential Liability
promptly after the indemnified Party becomes aware of such potential Liability.
The indemnifying Party shall have the right to assume the defense of any suit or
claim related to the Liability if it has assumed responsibility for the suit or
claim in writing; however, if in the reasonable judgment of the indemnified
Party, such suit or claim involves an issue or matter which could have a
materially adverse effect on the business operations or assets of the
indemnified Party, the indemnified Party may waive its rights to indemnity under
this Agreement and control the defense or settlement thereof, but in no event
shall any such waiver be construed as a waiver of any indemnification rights
such Party may have at law or in equity. If the indemnifying party defends the
suit or claim, the indemnified Party may participate in (but not control) the
defense thereof at its sole cost and expense.

                  11.4 Settlements. Neither Party may settle a claim or action
related to a Liability without the consent of the other Party, if such
settlement would impose any monetary obligation on the other Party or require
the other Party to submit to an injunction or otherwise limit the other Party's
rights under this Agreement. Any payment made by a Party to settle any such
claim or action shall be at its own cost and expense.

                  11.5 Limitation of Liability. With respect to any claim by one
Party against the other arising out of the performance or failure of performance
of the other Party under this Agreement, the Parties expressly agree that the
liability of such Party to the other Party for such breach shall be limited
under this Agreement or otherwise at law or equity to direct damages only and in
no event shall a Party be liable for, punitive, exemplary or consequential
damages.

                                       41
<PAGE>   48
                  11.6 Insurance. Each Party acknowledges that they each
maintain and shall, during the term of this Agreement, maintain a self-insurance
program for liability insurance, including products liability and contractual
liability insurance, adequately covering such Party's obligations under this
Agreement. Each Party shall provide the other Party with evidence of such
self-insurance program, upon request.

                                   ARTICLE 12

                              TERM AND TERMINATION

                  12.1 Term of Agreement. The term of this Agreement shall begin
on the Effective Date and shall continue in perpetuity unless terminated earlier
in accordance with this Article 12. Upon the expiration of the Exclusive Period,
(a) Schering shall be granted a worldwide, perpetual, fully-paid up,
non-exclusive license in and to the Know-How to enable Schering to develop,
make, have made, use, sell and distribute Product in the Territory, and (b)
Schering shall grant ICN reference to any Regulatory Approvals and pricing or
reimbursement approvals relating to the Product in the Territory.

                  12.2 Termination by Either Party. This Agreement may be
terminated upon written notice to the other Party in the event of any of the
following:

                  (a)      unilaterally by Schering at any time, with or without
                           cause, upon [REDACTED] written notice;

                  (b)      by either Party upon nonpayment of any properly due
                           and payable amount that is continuing for twenty (20)
                           business days after the defaulting Party has received
                           written notice from the non-defaulting Party of such
                           nonpayment;

                  (c)      by either Party upon material breach by the other
                           Party of any provision herein that is continuing
                           forty-five (45) days after the non-breaching Party
                           gives the breaching Party notice of such breach
                           specifying in reasonable detail the particulars of
                           the alleged breach; or

                  (d)      by either Party in the event the other Party becomes
                           insolvent, or voluntary or involuntary proceedings
                           are instituted by or against the other Party and are
                           not dismissed within 60 days, or a receiver or
                           custodian is appointed for such Party's business, or
                           a substantial portion of such Party's business is
                           subject to attachment or similar process, or the
                           other Party is unable to satisfy its obligations as
                           they become due, enters into any composition or
                           arrangement with its creditors or enters into
                           liquidation.

                                       42
<PAGE>   49
                  12.3 Continuing Obligations. Neither ICN nor Schering shall be
relieved of their respective obligations to pay any sums of money due or payable
or accrued under this Agreement as of the effective date of such termination.
All accounts between ICN and Schering shall be settled in full within ninety
(90) days following the expiration or termination of this Agreement. Articles 9,
10 and 13 and Sections 3.1(d), 3.9, 4.3(b), 4.3(k), 6.10, Article 11, 12.7(a),
15.9, this Section 12.3 and any other provision which by its terms is stated to
survive this Agreement, shall survive the termination or expiration of this
Agreement. In addition, any other provision required to interpret and enforce
the Parties' rights and obligations under this Agreement also shall survive to
the extent required for the full observation and performance of this Agreement
by the Parties hereto.

                  12.4 Partial Termination of Territory by ICN. Subject to the
terms and conditions of Section 3.4 hereof, ICN may terminate Schering's rights
with respect to a particular country within the Territory, effective upon sixty
(60) days' written notice to Schering if Schering has failed to make any
commercial sale of the Product in such country within six (6) months following
Regulatory Approval with the Minimum Labelling with respect to the Product in
such country. Upon such termination, Schering shall grant ICN reference to all
applicable Regulatory Approvals and pricing or reimbursement approvals related
to the Product in order to enable ICN to market, sell or promote the Product in
such country, or appoint any agent, distributor or other entity to do so,
without liability to Schering.

                  12.5 Effects of Termination by Schering.

                  (a)      In the event of termination of this Agreement by
                           Schering under Section 12.2 (a), and if termination
                           occurs prior to Regulatory Approval of the Product in
                           any country of the Territory then the following shall
                           occur: (i) Schering shall be granted a worldwide,
                           perpetual, non-exclusive license in and to the
                           Know-How to enable Schering to make, have made, use
                           and sell Product in the Territory; (ii) Schering
                           shall provide to ICN all reports, data, samples (if
                           necessary), and, if specifically required by a
                           regulatory authority, other information, necessary to
                           allow ICN to file for Regulatory Approval in any such
                           country either concurrently with Schering or, if
                           Schering is not then pursuing Regulatory Approval in
                           such country, within a reasonable time period; (iii)
                           Schering shall pay to ICN the royalties (including
                           minimum royalties) provided for under and in
                           accordance with Section 6.2 hereof with respect to
                           any and all sales of Product by Schering in the
                           Territory; and (iv) Schering-Plough Corporation shall
                           have no obligation to make the purchases of common
                           stock of ICN as set forth in the Stock Purchase
                           Agreement which are triggered by Regulatory Approval
                           in the United States and

                                       43
<PAGE>   50
                           the EU if the relevant Regulatory Approval has not
                           occurred as of the termination by Schering.

                  (b)      In the event of termination of this Agreement by
                           Schering under Section 12.2(a) and if termination
                           occurs after Regulatory Approval of the Product in
                           any country of the Territory then the following shall
                           occur: (i) Schering shall be granted a worldwide,
                           perpetual, non-exclusive license and in to the
                           Know-How to enable Schering to make, have made, use
                           and sell Product in the Territory; (ii) Schering
                           shall grant ICN reference to any Regulatory Approvals
                           and pricing or reimbursement approvals relating to
                           the Product outside of the EU; (iii) Schering shall
                           provide to ICN all reports, data, samples (if
                           necessary), and, if specifically required by a
                           regulatory authority, other information, necessary to
                           allow ICN to file for Regulatory Approval in the
                           Territory; (iv) Schering shall pay to ICN the
                           royalties (including minimum royalties) provided for
                           and in accordance with the terms of Section 6.2
                           hereof with respect to any and all sales of Product
                           by Schering in the Territory; and (v) Schering-Plough
                           Corporation shall have no obligation to make the
                           purchases of common stock of ICN as set forth in the
                           Stock Purchase Agreement which are triggered by
                           Regulatory Approval in the United States and the EU
                           if the relevant Regulatory Approval has not occurred
                           as of the termination by Schering.

                  (c)      In the event of termination of this Agreement by
                           Schering under Section 12.2(a), unless Schering fully
                           complies with the provisions of Sections 12.5(a) and
                           12.5(b) above, Schering shall not manufacture, use or
                           sell the Product in the Territory for a period of
                           three years from the date of termination of this
                           Agreement.

                  (d)      In the event of termination of this Agreement by
                           Schering under Sections 12.2(b), (c) or (d), without
                           limiting any other rights or remedies Schering may
                           have, the following shall occur: (i) Schering shall
                           retain a worldwide, perpetual, fully-paid up,
                           exclusive license (exclusive even as to ICN,
                           including in the EU) in and to the Know-How to enable
                           Schering to develop, make, have made, use, sell and
                           distribute Product in the Territory; (ii) Schering
                           shall be obligated to pay to ICN any royalties (other
                           than any minimum royalties) provided for under
                           Section 6.2 hereof with respect to any and all sales
                           of Product by Schering in the Territory; provided,
                           however, that such royalties shall be offset and/or
                           reduced to reflect damage suffered by Schering in the
                           event of a breach of this Agreement giving rise to
                           Schering's right to terminate, to the extent
                           determined

                                       44
<PAGE>   51
                           by the neutral in accordance with the provisions of
                           Article 13; and (iii) Schering-Plough Corporation
                           shall have no obligation to make the purchases of
                           common stock of ICN as set forth in the Stock
                           Purchase Agreement which are triggered by Regulatory
                           Approval in the United States and the EU if the
                           relevant Regulatory Approval has not occurred as of
                           the termination by Schering.

                  12.6 Effects of Termination by ICN.

                  (a)      In the event of termination of this Agreement by ICN
                           under Sections 12.2(b) or (d) then all of the rights
                           granted to Schering under this Agreement shall
                           terminate. Except as set forth immediately below in
                           Section 12.6(b), in the event of termination of this
                           Agreement by ICN pursuant to 12.2(c), all of the
                           rights granted to Schering under this Agreement shall
                           terminate.

                  (b)      In the event of a material breach by Schering of its
                           obligations under Section 3.1(a) (research and
                           development obligations), or Section 4.1 (diligence
                           in marketing the Product), which material breach is
                           continuing after the cure period provided for in
                           Section 12.2(c), then the rights granted to Schering
                           under this Agreement shall terminate on a
                           country-by-country basis relative to the country of
                           the Territory in which Schering's breach occurred.

                  12.7 Change of Control.

                  (a)      Schering agrees not to effect or in any way
                           participate in or facilitate a change of control of
                           ICN for a period of [REDACTED] following the date of
                           this Agreement, unless requested by ICN's board of
                           directors.

                  (b)      For purposes of this Section 12.7, a "change of
                           control" means (i) a merger, consolidation or
                           combination in which a Party to this Agreement is not
                           the surviving corporation, (ii) any "person" (within
                           the meaning of Section 13(d) and Section 14(d) (2) of
                           the Securities Exchange Act of 1934) is or becomes
                           the beneficial owner, directly or indirectly, of
                           securities of the Party representing [REDACTED] or
                           more of the combined voting power of the Party's
                           then-outstanding securities; or (iii) during any
                           period of two consecutive years, individuals who at
                           the beginning of such period constitute the Board of
                           Directors cease for any reason to constitute at least
                           a majority thereof, unless the election of each new
                           director by the Party's stockholders was approved by
                           a vote of at least two-thirds of the directors then
                           still in office who were directors at the beginning
                           of the period.

                                       45
<PAGE>   52
                  12.8 Remedy Not Exclusive. The exercise by a Party of any
right of termination under this Agreement shall be in addition to, and shall not
constitute a waiver of, any other right or remedy the Party may have at law or
in equity.

                                   ARTICLE 13

                               DISPUTE RESOLUTION

                  (a)      The Parties recognize that a bona fide dispute as to
                           certain matters may from time to time arise during
                           the Exclusive Period which relate to either Party's
                           rights and/or obligations hereunder. In the event of
                           the occurrence of such a dispute, either Party may,
                           by written notice to the other Party, have such
                           dispute referred to their respective officers
                           designated below or their successors, for attempted
                           resolution by good faith negotiations within thirty
                           (30) days after such notice is received. Said
                           designated officers are as follows:

<TABLE>
<S>                                          <C>
                           For ICN           [REDACTED] - President
                           For Schering      [REDACTED] - President
</TABLE>

In the event the designated officers are not able to resolve such dispute
through good faith negotiations within such (30) thirty-day period, either Party
may invoke the provisions of paragraph (b) below any time within such thirty day
period.

                  (b)      Except for Schering's unilateral right to terminate
                           this Agreement pursuant to Section 12.2(a), which
                           shall not be subject to the dispute resolution
                           process set forth in this Article 13, any dispute,
                           controversy or claim arising out of or relating to
                           the validity, construction, enforceability or
                           performance of this Agreement including disputes
                           relating to an alleged breach or termination of this
                           Agreement shall be settled by binding Alternative
                           Dispute Resolution ("ADR") in the manner described
                           below; provided, however, that in resolving any such
                           dispute the neutral referred to below shall give
                           effect to the provisions of this Agreement and shall
                           not adjust, modify or change the effects of
                           termination as set forth in Sections 12.5 and 12.6:
                           58

                           (i)      If a Party intends to begin an ADR to
                                    resolve a dispute, such Party shall provide
                                    written notice (the "ADR Request") by
                                    certified or registered mail or properly
                                    documented overnight delivery to the other
                                    Party informing such other Party of such
                                    intention and the issues to be resolved. The
                                    notice shall explain the nature of the
                                    complaint and refer to the relevant sections
                                    of

                                       46
<PAGE>   53
                                    the Agreement upon which the complaint is
                                    based. The complaining Party shall also set
                                    forth a proposed solution to the problem,
                                    including a suggested time frame within
                                    which the Parties must act.

                           (ii)     The non-complaining Party must respond in
                                    writing within forty-five (45) of receiving
                                    the notice with an explanation, including
                                    references to the relevant provisions of the
                                    Agreement and a response to the proposed
                                    solution and suggested time frame for
                                    action. The non-complaining Party may add
                                    additional issues to be resolved.

                           (iii)    Within fifteen (15) days of receipt of the
                                    response from the non-complaining Party, the
                                    Parties shall meet and discuss options for
                                    resolving the dispute. The complaining Party
                                    must initiate the scheduling of this
                                    resolution meeting. Each Party shall make
                                    available all appropriate personnel to meet
                                    and confer with the other Party within the
                                    fifteen (15) days period following the
                                    complaining Party's receipt of the response
                                    by the non-complaining Party.

                           (iv)     Any and all disputes that cannot be resolved
                                    pursuant to Section 13(b)(iii) shall be
                                    submitted to a neutral who shall be selected
                                    by the then-President of the Center for
                                    Public Resources ("CPR"), 680 Fifth Avenue,
                                    New York, New York 10019. The neutral shall
                                    be an individual who shall preside over and
                                    resolve any disputes between the Parties.
                                    The neutral selected shall be a former judge
                                    of a state or federal court selected from
                                    the Judicial Panel of the CPR and shall not
                                    be an employee, director or shareholder of,
                                    or otherwise have any current or previous
                                    relationship with, either Party or of an
                                    Affiliate of any Party. Either Party shall
                                    have ten (10) business days from the date
                                    the neutral is selected to object in good
                                    faith to the selection of that person. If
                                    either Party makes such an objection, the
                                    Parties shall instruct the then-President of
                                    the CPR to select, as soon as possible
                                    thereafter and in any event within ten (10)
                                    days, another neutral under the same
                                    conditions set forth above. This second
                                    selection shall be final. The ADR shall be
                                    conducted in accordance with the rules of
                                    the CPR then in effect, subject to the time
                                    periods and other provisions of this Article
                                    13.

                           (v)      Consistent with the time schedule
                                    established pursuant to Section 13(b)(vi),
                                    the neutral shall hold a hearing to resolve

                                       47
<PAGE>   54
                                    each of the issues identified by the Parties
                                    and shall render the award as expeditiously
                                    thereafter as possible but in no event more
                                    than thirty (30) days after the close of
                                    hearings. In making the award the neutral
                                    shall rule on each disputed issue and shall
                                    adopt in whole or in part the proposed
                                    ruling of one of the Parties on each
                                    disputed issue.

                           (vi)     During the meeting referred to in Section
                                    13(b)(iii), the Parties shall negotiate in
                                    good faith the scope and schedule of
                                    discovery, relating to depositions, document
                                    production and other discovery devices,
                                    taking into account the nature of the
                                    dispute submitted for resolution. If the
                                    Parties are unable to reach agreement as to
                                    the scope and schedule of discovery, the
                                    neutral may order such discovery as he deems
                                    necessary. To the extent practicable taking
                                    into account the nature of the dispute
                                    submitted for resolution, such discovery
                                    shall be completed within sixty (60)days
                                    from the date of selection of the neutral.
                                    At the hearing, which shall commence within
                                    twenty (20) days after completion of
                                    discovery unless the neutral otherwise
                                    orders, the Parties may present testimony
                                    (either by live witness or deposition),
                                    subject to cross-examination, and
                                    documentary evidence. To the extent
                                    practicable taking into account the nature
                                    of the dispute submitted for resolution and
                                    the availability of the neutral, the hearing
                                    shall be conducted over thirty (30)
                                    consecutive business days, with each Party
                                    entitled to approximately half of the
                                    allotted time unless otherwise ordered by
                                    the neutral. The hearing shall be held in
                                    the United States at such place as agreed
                                    upon by the Parties or if they are unable to
                                    agree at a place designated by the neutral.
                                    Each Party shall have the right to be
                                    represented by counsel. The neutral shall
                                    have sole discretion with regard to the
                                    admissibility of any evidence and all other
                                    matters relating to the conduct of the
                                    hearing. The neutral shall, in rendering his
                                    decision, apply the substantive law of New
                                    Jersey. The decision of the neutral shall be
                                    final and not appealable, except in cases of
                                    fraud or bad faith on the part of the
                                    neutral or any Party to the ADR proceeding
                                    in connection with the conduct of such
                                    proceedings.

                           (vii)    At least twenty (20) business days prior to
                                    the date set for the hearing, each Party
                                    shall submit to each other Party and the
                                    neutral a list of all documents on which
                                    such Party intends to rely in any oral or
                                    written presentation to the neutral and a
                                    list

                                       48
<PAGE>   55
                                    of all witnesses, if any, such Party intends
                                    to call at such hearing and a brief summary
                                    of each witness' testimony. At least five
                                    (5) business days prior to the hearing, each
                                    Party must submit to the neutral and serve
                                    on each other Party a proposed findings of
                                    fact and conclusions of law on each issue to
                                    be resolved. Following the close of
                                    hearings, the Parties shall each submit such
                                    post-hearing briefs to the neutral
                                    addressing the evidence and issues to be
                                    resolved as may be required or permitted by
                                    the neutral.

                  (c)      The neutral shall determine the proportion in which
                           the Parties shall pay the costs and fees of the ADR.
                           Each Party shall pay its own costs (including,
                           without limitation, attorneys fees) and expenses in
                           connection with such ADR; provided, however, that if
                           the neutral determines that the action of any Party
                           was arbitrary, frivolous or in bad faith, the neutral
                           may award such costs (including, without limitation,
                           attorneys fees) and expenses to the prevailing Party.

                  (d)      The ADR proceeding shall be confidential and, except
                           as required by law, neither Party shall make (or
                           instruct the neutral to make) any public announcement
                           with respect to the proceedings or decision of the
                           neutral without the prior written consent of the
                           other Party. The existence of any dispute submitted
                           to ADR, and the award of the neutral, shall be kept
                           in confidence by the Parties and the neutral, except
                           as required in connection with the enforcement of
                           such award or as otherwise required by applicable
                           law.

                  (e)      For the purposes of this Article 13, the Parties
                           acknowledge their diversity and agree to accept the
                           jurisdiction of the Federal District Court in Newark,
                           New Jersey for the purposes of enforcing awards
                           entered pursuant to this Article and for enforcing
                           the agreements reflected in this Article.

                  (f)      Nothing contained herein shall be construed to permit
                           the arbitrator(s) or any court or any other forum to
                           award punitive, exemplary or any similar damages. By
                           entering into this Agreement to arbitrate, the
                           Parties expressly waive any claim for punitive,
                           exemplary or any similar damages. The only damages
                           recoverable under this Agreement are compensatory
                           damages.

                  (g)      The procedures specified in this Article 13 shall be
                           the sole and exclusive procedures for the resolution
                           of disputes between the Parties arising out of or
                           relating to this Agreement; provided, however, that a
                           Party, without prejudice to the above procedures,

                                       49
<PAGE>   56
                           may seek a preliminary injunction or other
                           provisional judicial relief (which may include an
                           order of specific performance), if in its sole
                           judgment such action is necessary to avoid
                           irreparable damage or to preserve the status quo
                           (including, without limitation, in the event of a
                           breach by Schering of Section 12.7(a)). If a
                           preliminary injunction is granted, the Parties agree
                           that the final relief, including but not limited to,
                           the issuance of a permanent injunction, will be
                           decided by the neutral according to the procedures
                           outlined in this Article 13. If a preliminary
                           injunction is denied, the preliminary injunction
                           action will be discontinued and the neutral shall be
                           responsible for deciding the issue that was the
                           subject of the preliminary injunction action, and all
                           costs and expenses incurred by the prevailing Party
                           in defending such a preliminary injunction action
                           shall be reimbursed by the non-prevailing Party.
                           Despite the preliminary injunction action the Parties
                           will continue to participate in good faith in the ADR
                           according to the procedures specified in this Article
                           13.

                                   ARTICLE 14

                            PROVISION FOR INSOLVENCY

                  (a)      All rights and licenses granted under or pursuant to
                           this Agreement by ICN to Schering are, for all
                           purposes of Section 365(n) of Title 11 of the U.S.
                           Code ("Title 11"), licenses of rights to intellectual
                           property as defined in Title 11. ICN agrees during
                           the Exclusive Period to maintain and preserve any
                           current copies of all such intellectual property
                           which are in existence and in its possession as of
                           the commencement of a case under Title 11 by or
                           against ICN. If a case is commenced by or against ICN
                           under Title 11, then, unless and until this Agreement
                           is rejected as provided in Title 11, ICN (in any
                           capacity, including debtor-in-possession) and its
                           successors and assigns (including, without
                           limitation, a Title 11 Trustee) shall, as Schering
                           may elect in a written request, immediately upon such
                           request (A) (i) perform all of the obligations
                           provided in this Agreement to be performed by ICN, or
                           (ii) provide to Schering all such intellectual
                           property (including all embodiments thereof) held by
                           ICN and such successors and assigns as of the
                           commencement of a case under Title 11 by or against
                           ICN and from time to time thereafter, and (B) not
                           interfere with the rights of Schering as provided in
                           this Agreement, or any agreement supplementary
                           hereto, to such intellectual property (including all
                           such embodiments

                                       50
<PAGE>   57
                           thereof, including any right of Schering to obtain
                           such intellectual property (or such embodiment) from
                           any other entity.

                  (b)      If a Title 11 case is commenced by or against ICN,
                           this Agreement is rejected as provided in Title 11
                           and Schering elects to retain its rights hereunder as
                           provided in Title 11, then ICN (in any capacity,
                           including debtor-in-possession) and its successors
                           and assigns (including, without limitation, a Title
                           11 Trustee) shall provide to Schering all such
                           intellectual property (including all embodiments
                           thereof) held by ICN and such successors and assigns
                           immediately upon Schering's written request therefor.
                           Whenever ICN or any of its successors or assigns
                           provides to Schering any of the intellectual property
                           licensed hereunder (or any embodiment thereof)
                           pursuant to this Article 14, Schering shall have the
                           right to perform the obligations of ICN hereunder
                           with respect to such intellectual property, but
                           neither such provision nor such performance by
                           Schering shall release ICN from any such obligation
                           or liability for failing to perform it; provided,
                           however, that in such event Schering shall not be
                           entitled to compel specific performance by ICN under
                           this Agreement except to the extent of enforcing the
                           exclusivity of the license granted hereunder.

                  (c)      All rights, powers, remedies, obligations and
                           conditions of Schering provided herein are in
                           addition to and not in substitution for any and all
                           other rights, powers, remedies, obligations and
                           conditions of ICN or Schering now or hereafter
                           existing at law or in equity (including, without
                           limitation, Title 11) in the event of the
                           commencement of a Title 11 case by or against ICN.
                           Schering, in addition to the rights, power and
                           remedies expressly provided herein, shall be subject
                           to all obligations and conditions, and shall be
                           entitled to exercise all other such rights and powers
                           and resort to all other such remedies as may now or
                           hereafter exist at law or in equity (including,
                           including, without limitation, Title 11) in such
                           event. The Parties agree that they intend the
                           foregoing rights and obligations of Schering to apply
                           to the maximum extent permitted by law, including
                           without limitation for purposes of Title 11, (i) the
                           right of access to any intellectual property
                           (including all embodiments thereof) of ICN, or any
                           third party with whom ICN contracts to perform an
                           obligation of ICN under this Agreement, and, in the
                           case of the third party, which is necessary for the
                           development, registration and manufacture of Product,
                           and (ii) the right to contract directly with any
                           third party described in clause (i) in this sentence
                           to complete the contracted work.

                                       51
<PAGE>   58

                                  ARTICLE 15

                                MISCELLANEOUS

            15.1 Assignment. Neither this Agreement nor any or all of the rights
and obligations of a Party hereunder shall be assigned, delegated, sold,
transferred, sublicensed or otherwise disposed of, by operation of law or
otherwise, to any third party other than an Affiliate of such Party, without the
prior written consent of the other Party, and any attempted assignment,
delegation, sale, transfer, sublicense or other disposition, by operation of law
or otherwise, of this Agreement or of any rights or obligations hereunder
contrary to this Section 15.1 shall be a material breach of this Agreement by
the attempting Party, and shall be void and without force or effect. This
Agreement shall be binding upon, and inure to the benefit of, each Party, its
Affiliates, and its permitted successors and assigns. Each Party shall be
responsible for the compliance by its Affiliates with the terms and conditions
of this Agreement.

            15.2 Governing Law. This Agreement shall be governed, interpreted
and construed in accordance with the laws of the State of New Jersey, without
giving effect to conflict of law principles.

            15.3 Waiver. A waiver of any breach or any provision of this
Agreement shall not be construed as a continuing waiver of other breaches of the
same or other provisions of this Agreement.

            15.4 Independent Relationship. Nothing herein contained shall be
deemed to create an employment, agency, joint venture or partnership
relationship between the Parties hereto or any of their agents or employees, or
any other legal arrangement that would impose liability upon one Party for the
act or failure to act of the other Party. Neither Party shall have any power to
enter into any contracts or commitments or to incur any liabilities in the name
of, or on behalf of, the other Party, or to bind the other Party in any respect
whatsoever.

            15.5 Export Control. This Agreement is made subject to any
restrictions concerning the export of products or technical information from the
United States of America which may be imposed upon or related to ICN or Schering
from time to time by the government of the United States of America.
Furthermore, Schering agrees that it will not export, directly or indirectly,
any technical information acquired from ICN under this Agreement or any products
using such technical information to any country for which the United States
government or any agency thereof at the time of export requires an export
license or other governmental approval, without first obtaining the written
consent to do so from the Department of Commerce or other agency of the United
States government when required by an applicable statute or regulation.

            15.6 Entire Agreement; Amendment. This Agreement, including the
Exhibits hereto, sets forth the complete,

                                       52
<PAGE>   59
final and exclusive agreement and all the covenants, promises, agreements,
warranties, representations, conditions and understandings between the Parties
hereto and supersedes and terminates all prior agreements and understandings
between the Parties. There are no covenants, promises, agreements, warranties,
representations, conditions or understandings, either oral or written, between
the Parties other than as are set forth herein and therein. No subsequent
alteration, amendment, change or addition to this Agreement shall be binding
upon the Parties unless reduced to writing and signed by an authorized officer
of each Party.

            15.7 Notices. Each notice required or permitted to be given or sent
under this Agreement shall be given by facsimile transmission (with confirmation
copy by registered first-class mail) or by registered or overnight courier
(return receipt requested), to the Parties at the addresses and facsimile
numbers indicated below.

                  If to ICN, to:

                  ICN Pharmaceuticals, Inc.
                  ICN Plaza
                  330 Hyland Avenue
                  Costa Mesa, California 92626
                  Attention: President
                  Facsimile Number (714) 641-7276

                  If to Schering, to:

                  Schering-Plough Ltd.
                  Toepferstrasse 5
                  CH-6004 Lucerne,
                  Switzerland
                  Attention: President
                  FAX: 41-41-52-1626

                  with copies to:

                  Schering-Plough International
                  2000 Galloping Hill Road
                  Kenilworth, NJ 07033
                  Attention: President
                  FAX: (908) 298-5379

                   and

                                       53
<PAGE>   60
                  Schering Corporation
                  1 Giralda Farms
                  Madison, NJ 07940
                  Attention: Joseph C.  Connors,
                  Senior Vice President and
                  General Counsel
FAX: (201) 822-1960

Any such notice shall be deemed to have been received on the earlier of the date
actually received and the date five (5) days after the same was posted. Either
Party may change its address or its FAX number by giving the other Party written
notice, delivered in accordance with this Section.

            15.8 Force Majeure. Failure of any Party to perform its obligations
under this Agreement (except the obligation to make payments when properly due)
shall not subject such Party to any liability or place them in breach of any
term or condition of this Agreement to the other Party if such failure is caused
by any cause beyond the reasonable control of such non-performing Party,
including without limitation acts of God, fire, explosion, flood, drought, war,
riot, sabotage, embargo, strikes or other labor trouble, failure in whole or in
part of suppliers to deliver on schedule materials, equipment or machinery,
interruption of or delay in transportation, a national health emergency or
compliance with any order or regulation of any government entity acting with
color of right. If a condition constituting force majeure as defined herein
exists for more than ninety (90) consecutive days, the Parties shall meet to
negotiate a mutually satisfactory solution to the problem, if practicable.

            15.9 Non-Solicitation. To the maximum extent permitted by applicable
law, during the Exclusive Period and for one (1) year thereafter, neither Party
shall, directly or indirectly, solicit any individual who is then an employee of
a Party or its Affiliate within the Territory and who was involved in the
manufacturing, marketing, distribution or sale of the Product under this
Agreement, unless consented to in writing by the other Party.

            15.10 Severability. If any provision of this Agreement is declared
invalid or unenforceable by a court having competent jurisdiction, it is
mutually agreed that this Agreement shall endure except for the part declared
invalid or unenforceable by, order of such court. The Parties shall consult and
use their best efforts to agree upon a valid and enforceable provision which
shall be a reasonable substitute for such invalid or unenforceable provision in
light of the intent of this Agreement.

                                       54
<PAGE>   61
            15.11 Counterparts. This Agreement shall become binding when any one
or more counterparts hereof, individually or taken together, shall bear the
signatures of each of the Parties hereto. This Agreement may be executed in any
number of counterparts, each of which shall be an original as against either
Party whose signature appears thereon, but all of which taken together shall
constitute but one and the same instrument.

                                       55
<PAGE>   62
            IN WITNESS WHEREOF, the Parties hereto have caused their duly
authorized officers to execute this Agreement.

                        ICN PHARMACEUTICALS, INC.

                         By: /s/ DAVID C.  WATT
                             ----------------------------
                         Name: David C.  Watt
                         Title: Executive Vice President,
                         General Counsel & Corporate Secretary

                        SCHERING-PLOUGH LTD.

                         By: /s/ DAVID POORVIN, Ph.D.
                             ----------------------------
                         Name: David Poorvin, Ph.D.
                         Title: Prokurist

                                       56
<PAGE>   63
                                    GUARANTEE

            In consideration of ICN's execution of the foregoing Exclusive
License and Supply Agreement dated the date hereof ("Agreement"), Schering
Corporation ("Schering") hereby guarantees to ICN as principal and not as surety
the performance by Schering-Plough Ltd. and any Affiliate of Schering-Plough
Ltd. of all of Schering-Plough Ltd.'s obligations under the Agreement.

            Schering hereby consents to the jurisdiction of the courts
(including the Federal courts) in the State of California with respect to any
and all disputes, claims, actions or proceedings arising out of the execution,
delivery or performance of this Guarantee and waives all rights it might
otherwise have to object to venue before, and the jurisdiction of, such courts.
Nothing herein shall in any way detract from or limit the obligation of the
Parties to submit any dispute arising under the Agreement to arbitration and to
be bound by any decision of the neutral rendered in accordance with the dispute
resolution procedures set forth in Article 13 of the Agreement.

            This Guarantee shall survive the expiration or other termination of
the Agreement and shall survive and apply regardless of any amendments, waivers,
extensions, modifications or other changes in the obligations of Schering-Plough
Ltd. under the Agreement.

July 28, 1995           SCHERING CORPORATION

                        By: /s/ David Poorvin
                            ------------------------
                        Its:  Vice President

                                       57
<PAGE>   64
                                    EXHIBIT A

ICN shall not be required to supply Product at a price less than ICN's Cost of
Goods plus five percent.

Cost of Goods, if ICN or any Affiliate or third party is the manufacturer of
finished Product, shall include the following categories:

1.    Direct Materials

      Materials used in the manufacturing process that are traced directly to
      the completed Product, including, but not limited to:

      -     Inert raw materials or excipients

      -     Active substances/ingredients

      -     Packaging components such as bottles, caps, labels, etc.

2.    Direct Labor

      The Cost of employees engaged in production activities that are directly
      identifiable with Product costs. Excludes supervision (which is included
      in indirect labor) and production support activities such as inspection,
      plant and equipment maintenance labor, and material handling personnel.
      Direct Labor cost includes:

      -     Base pay, overtime, vacation and holidays, illness, personal time
            with pay, and shift differential.

      -     Cost of employee fringe benefits such as health and life insurance
            payroll taxes, welfare, pension and profit sharing.

3.    Indirect Manufacturing Costs

      Costs which are ultimately allocated to Product based on an appropriate
      method such as standard direct labor hours, tank hours, grams, vials, etc.
      of the operating departments. These costs include:

      -     Indirect Production Labor - salaries of employees engaged in
            production activities who are not classified as direct labor,
            including supervision, clerical, etc.

                                       58
<PAGE>   65
      -     Costs of certain direct labor - employees not utilized for the
            manufacturing of Product, such as training, downtime and general
            duties.

      -     Indirect Materials - supplies and chemicals which are used in the
            manufacturing process and are not assigned to specific Product but
            are included in manufacturing overhead costs. Includes supplies for
            which direct assignment to Product is not practical.

      -     Utilities - expenses incurred for communications, fuel, electricity
            and water in providing power for production and other plant
            equipment.

      -     Maintenance and repairs - amount of expense incurred in-house or
            purchased to provide services for plant maintenance and repairs of
            facilities and equipment.

      -     Other services - purchased outside services and rentals, such as the
            cost of security, ground maintenance, etc.

      -     Depreciation of plant and equipment utilizing the straight-line
            method of calculation.

      -     Insurance - cost of comprehensive and other insurance necessary for
            the safeguard of manufacturing plant and equipment.

      -     Taxes - expense incurred for taxes on real and personal property
            (manufacturing site, buildings and the fixed assets of equipment,
            furniture and fixtures, etc.). If manufacturing site includes other
            operations (marketing, R&D, etc.), taxes are allocated to
            manufacturing on the basis of total real and personal property.

      -     Cost of manufacturing service departments such as (where
            applicable):

            -     Packaging Engineering

            -     Manufacturing Maintenance

            -     Industrial Engineering

            -     Receiving and Warehousing

            -     Production Scheduling

            -     Inventory Scheduling

            -     Plant Materials management

            -     Central Weigh

                                       59
<PAGE>   66
            -     Manufacturing Administration

            -     Purchasing

            -     Accounting

      -     Allocated costs of services provided to manufacturing including:
            (where applicable):

            -     Cafeteria

                  -      Personnel Operations

                  -     Health and Safety Services

            -     Division Engineering and Operations Services

            -     Plant Services (housekeeping)

            -     Manufacturing Information Services

            -     Plant Power

            -     Office of VP Manufacturing

Various basis are used for allocating these costs to manufacturing operating
departments including head count, square feet, metered utilities use, estimated
services rendered, EDP computer hours, etc.

4.    Quality Assurance Costs - direct labor and indirect costs for Quality
      Assurance departments' testing and approving materials used in
      manufacturing and completed manufacturing batches and finished Product.
      This includes all manufacturing in-process testing and testing of finished
      materials. Excluded from Product costs are QA costs related to research
      and development, stability testing, etc.

The following are not included in manufacturing costs:

      (a)   Inventory Carrying Costs

      (b)   Regulatory Affairs costs

      (c)   Pilot plant costs - research batches and other similar costs prior
            to turnover to manufacturing. This excludes commercial goods
            produced by a research facility.

      (d)   Costs incurred for special projects to establish and certify new
            production processes, batch sizes, product line improvements and new
            vendor certification of equipment and primary materials components.

                                       60
<PAGE>   67
      (e)   Manufacturing start-up costs and initial one-time extraordinary
            manufacturing costs incurred prior to plant operations and
            achievement of a normal production activity level. Includes costs
            training, testing, qualification/validation of new equipment and
            facilities and initial trial batches.

      (f)   Significant idle capacity is eliminated from factory overhead and
            Product cost.
      (g)   Shipping and other distribution costs.

      (h)   Product liability and/or business interruption insurance
            expenses.

                                       61
<PAGE>   68
                                    EXHIBIT B

                                   [REDACTED]

                             PRODUCT SPECIFICATIONS

                                       62
<PAGE>   69
                                    EXHIBIT C

                            STOCK PURCHASE AGREEMENT

                                 BY AND BETWEEN

                            ICN PHARMACEUTICALS, INC.

                                       AND

                           SCHERING-PLOUGH CORPORATION

                                  JULY 28, 1995

                                       63
<PAGE>   70
                                TABLE OF CONTENTS

<TABLE>
<S>                                                                           <C>
1.    Purchase and Sale of Shares...........................................    1
      1.1   Purchase of Shares..............................................    1
      1.2   Closing dates; Delivery.........................................    3

2.    Representations and Warranties of the Company.........................    3
      2.1   Organization and Corporate Power................................    3
      2.2   Authorization...................................................    3
      2.3   Capitalization..................................................    4
      2.4   Subsidiaries....................................................    4
      2.5   Financial Statements............................................    4
      2.6   Absence of Undisclosed Liabilities..............................    4
      2.7   Absence of Certain Developments.................................    5
      2.8   Title to Properties.............................................    5
      2.9   Tax Matters.....................................................    5
      2.10  Intellectual Property...........................................    5
      2.11  Effect of Transactions..........................................    6
      2.12  No Governmental Consent or Approval Required....................    6
      2.13  Litigation......................................................    6
      2.14  Securities Laws.................................................    7
      2.15  Business........................................................    7
      2.16  Brokerage.......................................................    7
      2.17  Insurance.......................................................    7
      2.18  Environmental and Safety Laws...................................    7
      2.19  Retirement Obligations, etc.....................................    8
      2.20  Investment Company..............................................    8
      2.21  Registration Rights.............................................    8
      2.22  Employees.......................................................    8
      2.23  Absence of Certain Business Practices...........................    8
      2.24  Disclosure......................................................    9

3.    Representations and Warranties of Schering and Other Agreements.......    9

      3.1   Representations and Warranties..................................    9
      3.2   Further Provisions Regarding Disposition........................   11
      3.3   Legends.........................................................   11

4.    Conditions to Schering's Obligations at Closing.......................   11

      4.1   Initial Milestone Closing.......................................   11
      4.2   U.S.  Milestone Closing.........................................   13
</TABLE>
<PAGE>   71
<TABLE>
<S>                                                                           <C>
      4.3   EU Milestone Closing............................................   14

5.    Conditions of the Company's Obligations at Closing....................   15

      5.1   Initial Milestone Closing.......................................   15
      5.2   U.S.  Milestone Closing.........................................   16
      5.3   EU Milestone Closing............................................   16

6.    Registration of Common Stock; Covenants of the Company; Other
      Agreements............................................................   17
      6.1   Definitions.....................................................   17
      6.2   Demand Registration.............................................   18
      6.3   "Piggyback" Registration........................................   19
      6.4   Registration Expenses...........................................   21
      6.5   Registration Procedures.........................................   21
      6.6   Form S-3 Registration...........................................   23
      6.7   Indemnification.................................................   24
      6.8   Reports Under Exchange Act......................................   26
      6.9   Transferability.................................................   27
      6.10  Cross Default...................................................   27
      6.11  Limitation of Liability.........................................   28

7.    Miscellaneous.........................................................   28
      7.1   Survival of Warranties..........................................   28
      7.2   Incorporation by Reference......................................   28
      7.3   Parties in Interest.............................................   28
      7.4   Amendments and Waivers..........................................   28
      7.5   Governing Law...................................................   28
      7.6   Notices.........................................................   28
      7.7   Counterparts....................................................   29
      7.8   Effect of Headings..............................................   29
      7.9   Entire Agreement................................................   29
      7.10  Publicity.......................................................   29
      7.11  Severability....................................................   29
</TABLE>
<PAGE>   72
                            STOCK PURCHASE AGREEMENT

            This STOCK PURCHASE AGREEMENT (the "Agreement") is made as of this
28th day of July, 1995, by and between ICN Pharmaceuticals, Inc., a Delaware
corporation (the "Company") and Schering-Plough Corporation, a New Jersey
corporation ("Schering").

                                    RECITAL

            The Company and Schering are entering into this Agreement as an
inducement for the Company to enter into that certain Exclusive License and
Supply Agreement dated of even date herewith (the "License Agreement"). Pursuant
to this Agreement, Schering intends to invest in the Company and the proceeds of
such investment will be used by the Company for general corporate purposes.
Other than the right of Schering to vote its shares of Company common stock as
Schering deems appropriate, nothing contained in this Agreement is intended to
confer, or be deemed to confer, on Schering the power to direct, influence or
control the management, policies or operations of the Company.

                        THE PARTIES AGREE AS FOLLOWS:

            1. Purchase and Sale of Shares. Subject to the terms and conditions
of this Agreement and on the basis of the representations and warranties set
forth herein, the Company agrees to sell to Schering, and Schering agrees to
purchase from the Company, shares of the Company's common stock (the "Common
Stock"), as set forth below. The shares of Common Stock being purchased
hereunder are hereinafter referred to as the "Shares."

            1.1   Purchase of Shares.

            (a) On the Initial Milestone Closing Date (as defined below), the
Company shall sell to Schering and Schering shall purchase from the Company, for
a total consideration of [REDACTED], that number of Shares which equals (A)
[REDACTED] divided by (B) the average closing price of the Common Stock as
quoted on the New York Stock Exchange ("NYSE") for the 20 trading days ending on
the day immediately preceding the Initial Milestone Closing Date (or, if a stock
split or recapitalization occurred during such 20 day trading day period, then
for the 20 trading day period ending on the date of such stock split or
recapitalization).

            (b) On the U.S. Milestone Closing Date (as defined below), the
Company shall sell to Schering and Schering shall purchase from the Company, for
a total

                                      C-1
<PAGE>   73
consideration of [REDACTED], that number of Shares which equals (A) [REDACTED]
divided by (B) the average closing price of the Common Stock as quoted on the
NYSE for the 20 trading days ending on the day immediately preceding the U.S.
Milestone Closing Date (or, if a stock split or recapitalization occurred during
such 20 trading day period period, then for the 20 trading day period ending on
the date of such stock split or recapitalization).

            (c) On the EU Milestone Closing Date (as defined below), the Company
shall sell to Schering and Schering shall purchase from the Company, for a total
consideration of [REDACTED] that number of Shares which equals (A) [REDACTED]
divided by (B) the lower of (i) [REDACTED] (adjusted for stock splits,
recapitalizations, reclassifications or similar events occurring after the date
hereof and prior to the EU Milestone Closing Date) or (ii) the average closing
price of the Common Stock as quoted on the NYSE for the 20 trading day period
ending on the day immediately preceding the EU Milestone Closing Date (or, if a
stock split or recapitalization occurred during such 20 trading day period, then
for the 20 trading day period ending on the date of such stock split or
recapitalization).

            (d) Within 30 days following the satisfaction of the conditions set
forth in Section 4.1 below, the closing of the purchase and sale of Shares
hereunder as set forth in Section 1.1(a) above (the "Initial Milestone Closing")
shall be held at the offices of Schering-Plough Corporation (or such other place
as the parties shall mutually agree) at such time as the parties shall mutually
agree (the date of the Initial Milestone Closing is referred to herein as the
"Initial Milestone Closing Date"). At the Initial Milestone Closing, the Company
shall deliver to Schering a certificate or certificates, registered in
Schering's name, representing the Shares purchased at the Initial Milestone
Closing, and Schering shall pay the total consideration for such Shares by wire
transfer in immediately available funds to an account designated by the Company.

            (e) Within 30 days following the satisfaction of the conditions set
forth in Section 4.2 below, the closing of the purchase and sale of Shares
hereunder as set forth in Section 1.1(b) above (the "U.S. Milestone Closing")
shall be held at the offices of Schering-Plough Corporation (or such other place
as the parties shall mutually agree) at such time as the parties shall mutually
agree (the date of the U.S. Milestone Closing is referred to herein as the "U.S.
Milestone Closing Date"). At the U.S. Milestone Closing, the Company shall
deliver to Schering a certificate or certificates, registered in Schering's
name, representing the Shares purchased at the U.S. Milestone Closing, and
Schering shall pay the total consideration for such Shares by wire transfer in
immediately available funds to an account designated by the Company.

                                      C-2
<PAGE>   74
            1.2   Closing dates; Delivery.

            (a) Within 30 days following the satisfaction of the conditions set
forth in Section 4.3 below, the closing of the purchase and sale of Shares
hereunder as set forth in Section 1.1(c) above (the "EU Milestone Closing")
shall be held at the offices of Schering-Plough Corporation (or such other place
as the parties shall mutually agree) at such time as the parties shall mutually
agree (the date of the EU Milestone Closing is referred to herein as the "EU
Milestone Closing Date"). At the EU Milestone Closing, the Company shall deliver
to Schering a certificate or certificates, registered in Schering's name,
representing the Shares purchased at the EU Milestone Closing, and Schering
shall pay the total consideration for such Shares by wire transfer in
immediately available funds to an account designated by the Company.

            2. Representations and Warranties of the Company. Company hereby
represents and warrants to Schering that:

            2.1 Organization and Corporate Power. The Company is a corporation
duly organized, validly existing and in good standing under the laws of the
State of Delaware and is qualified to do business as a foreign corporation in
each jurisdiction where failure to so qualify would have a Material Adverse
Effect on the Company. For purposes of this Agreement, a "Material Adverse
Effect" or a "Material Adverse Change" shall mean, with respect to the Company,
any adverse effect or change in the condition (financial or other), business,
results of operations, assets, liabilities or operations of the Company or on
the ability of the Company to consummate any of the transactions contemplated
hereby, or any event or condition that would, with or without the passage of
time, constitute a "Material Adverse Effect" or "Material Adverse Change." The
Company has full power and authority to own its property, to carry on its
business as presently conducted and to carry out the transactions contemplated
hereby. The copies of the Certificate of Incorporation and Bylaws of the
Company, as amended to date, which have been furnished to Schering by the
Company, are correct and complete.

            2.2 Authorization. The Company has full power to execute, deliver
and perform this Agreement and each other agreement entered into by the Company
in connection with this Agreement. Each such agreement has been duly executed
and delivered by the Company and is the legal, valid and, assuming due execution
by the other parties hereto and thereto, binding obligation of the Company,
enforceable against the Company in accordance with its terms, subject to
applicable bankruptcy, insolvency, moratorium, reorganization or similar laws
affecting creditors, rights generally, and to general equitable principles. The
execution, delivery and performance of this Agreement, including the sale,
issuance and delivery of the Shares and each other agreement entered into by the
Company in connection with this Agreement, has been duly authorized by all
necessary corporate action of the Company.

                                      C-3
<PAGE>   75
            2.3 Capitalization. The entire authorized capital stock of the
Company consists of 100,000,000 shares of Common Stock, of which 29,188,829
shares are issued and outstanding, and 1,000,000 shares of Series A Preferred
Stock, none of which are issued and outstanding. The shares of Common Stock
outstanding are duly authorized, validly issued and outstanding, fully paid and
nonassessable, and were issued in compliance with all applicable federal and
state securities laws. No shares of Common Stock are held in the Company's
treasury. When issued in accordance with the terms of this Agreement, the Shares
will be duly authorized, validly issued and outstanding, fully paid and
nonassessable, free of any preemptive rights or rights of first refusal and will
be issued in compliance with all applicable federal and state securities laws.
Except as disclosed in the Financial Statements and SEC Filings (each as defined
below), there are no outstanding warrants, rights of first refusal, options or
other rights to purchase or acquire, or exchangeable for or convertible into,
any shares of Common Stock. The Company has reserved 5,333,000 shares of Common
Stock under its stock option plans. There are no preemptive rights with respect
to the issuance or sale by the Company of any of its securities. Upon
consummation of the transactions contemplated hereby, Schering will acquire good
and valid title to the Shares, free and clear of any encumbrances, liens,
claims, charges or assessments of any nature whatsoever.

            2.4 Subsidiaries. The Company has no subsidiaries, except as set
forth in Schedule 2.4.

            2.5 Financial Statements. The Company has delivered to Schering a
copy of the Company's Annual Report on Form 10-K for the fiscal year ended
December 31, 1994 (the "1994 10-K"), containing audited balance sheets,
statements of operations and cash flows for the Company for the fiscal years
ended December 31, 1994, December 31, 1993, and December 31, 1992 (the
"Financial Statements") and copies of the Company's Quarterly Reports on Form
10-Q for the quarters ended March 31, 1994, June 30, 1994, September 30, 1994
and March 31, 1995 (collectively, together with the 1994 10-K, the "SEC
Filings"). The Financial Statements are complete and correct in all matters and
respects, are in accordance with the books and records of the Company, have been
prepared in accordance with generally accepted accounting principles,
consistently applied, and fairly present the financial position of the Company
as of each such date and the results of operations for each such period then
ended.

            2.6 Absence of Undisclosed Liabilities. Except as and to the extent
reflected or stated in the SEC Filings and the Financial Statements, and except
for liabilities arising in the ordinary course of its business and consistent
with past practice, and liabilities not required to be set forth in the
Financial Statements, the Company has no material debts, liabilities or
obligations of any nature, whether accrued, contingent or absolute, assigned or
otherwise, or whether due or to become due.

                                      C-4
<PAGE>   76
            2.7 Absence of Certain Developments. Since January 1, 1995, except
as disclosed in the Financial Statements, there has not been (a) any Material
Adverse Change with respect to the Company, (b) any declaration, setting aside
or payment of any dividend or other distribution with respect to the capital
stock of the Company, (c) loss, destruction or damage to any property of the
Company, whether or not insured, which had or may have a Material Adverse Effect
on the Company, (d) any issuance of any stock, bonds or other securities of the
Company or options, warrants or rights or agreements or commitments to purchase
or issue such securities or grant such options, warrants or rights, or (e) any
change in the accounting methods or practices by the Company.

            2.8 Title to Properties. Except as disclosed in the Financial
Statements, the Company has good and marketable title to, or has a valid
leasehold interest in, or a valid license for, all of the material properties
and assets reflected in the Financial Statements, free and clear of all
mortgages, security interests, liens, restrictions or encumbrances other than
(i) the lien of current taxes not yet due and payable, and (ii) possible minor
liens and encumbrances which do not in any case, individually or in the
aggregate, materially detract from the value of the property subject thereto or
materially impair the operations of the Company, and would not result in the
occurrence of a Material Adverse Change, and which have not arisen otherwise
than in the ordinary course of business.

            2.9 Tax Matters. The provisions for taxes in the Financial
Statements are sufficient for the payment of all accrued and unpaid federal,
state, county and local taxes of the Company.

            2.10  Intellectual Property.

            (a) The Company has good title to and ownership of, free and clear
of all liens, claims and encumbrances of any nature, or a valid license to, all
patents, patent rights, patent applications, inventions, trademarks, service
marks, trade names, copyrights and information, proprietary rights and processes
necessary to the proper conduct of its business as described in the SEC Filings
and the Financial Statements (the "Proprietary Rights"); and (ii) to the best
knowledge of the Company, such business does not conflict with or constitute an
infringement of the rights of others.

            (b) The Company has not received any communications alleging that,
and has no knowledge that the Company has violated or, by conducting its
business, would violate any of the patents, patent applications, inventions,
trademarks, service marks, trade names, copyrights or trade secrets,
information, proprietary rights or processes of any other person or entity.

            (c) No other firm, corporation, association or person (i) has
notified the Company that such firm, corporation, association or person is
claiming any ownership of

                                      C-5
<PAGE>   77
or right to use any of the Proprietary Rights or (ii) to the best of the
Company's knowledge, is infringing upon any such Proprietary Rights in any way
that could reasonably be expected to have a Material Adverse Effect on the
Company.

            2.11 Effect of Transactions. The execution, delivery and performance
of this Agreement and the transactions contemplated hereby, and compliance with
the provisions hereof by the Company, do not and will not, with or without the
passage of time or the giving of notice or both, (a) violate, in any material
respect, any provision of law, statute, rule or regulation or any ruling, writ,
injunction, order, judgment or decree of any court, administrative agency or
other governmental body or (b) conflict with or result in any breach of any of
the terms, conditions or provisions of, or constitute a default (or give rise to
any right of termination, cancellation or acceleration) under, or result in the
creation of any lien, security interest, charge or encumbrance upon any of the
properties or assets of the Company under the Certificate of Incorporation or
Bylaws, as amended to date, of the Company or any material note, indenture,
mortgage, lease, agreement, contract, purchase order or other material
instrument, document or agreement to which the Company is a party or by which it
or any of its properties or assets is bound or affected, except as would not
have a Material Adverse Effect on the Company.

            2.12 No Governmental Consent or Approval Required. Based in part on
the representations made by Schering in Section 3 of this Agreement, no
authorization, consent, approval or other order of, declaration to, or
registration, qualification, designation or filing with, any federal, state or
local governmental agency or body is required for or in connection with the
valid and lawful authorization, execution and delivery by the Company of this
Agreement or any other agreement entered into by the Company in connection with
this Agreement, and the consummation of the transactions contemplated hereby or
thereby, or for or in connection with the valid and lawful authorization,
issuance, sale and delivery of the Shares other than the qualification (or
taking of such action as may be necessary to secure an exemption from
qualification if available) of the offer and sale of the Shares under the
applicable state securities laws, which filings and qualifications, if required,
will be accomplished in a timely manner so as to comply with such qualification
or exemption from qualification requirements.

            2.13 Litigation. Except as disclosed in the SEC Filings, there is no
claim, arbitration, action, suit, proceeding, investigation or inquiry pending,
or to the best knowledge of the Company, threatened against the Company, which
questions the validity of this Agreement or any other agreement entered into by
the Company in connection with this Agreement or the right of the Company to
enter into any such agreements or to consummate the transactions contemplated
hereby or thereby, or which might result, either individually or in the
aggregate, in any Material Adverse Effect on the Company, or any change in the
current equity ownership of the Company. The information described on Schedule
2.13 is not material to the business, assets or

                                      C-6
<PAGE>   78
operations of the Company or its subsidiaries (taken as a whole), no Current
Report on Form 8-K need be filed with the Securities and Exchange Commission
(the "SEC") to report such information, and such information will be disclosed
in the Company's Quarterly Report on Form 10-Q for the second quarter to be
filed with the SEC on or before August 14, 1995. The Company is not a party to,
or subject to the provisions of, any order, writ, injunction, judgment or decree
of any court or governmental agency or instrumentality which would have a
Material Adverse Effect on the Company.

            2.14 Securities Laws. Assuming that Schering's representations and
warranties contained in Section 3 of this Agreement are true and correct, the
offer, issuance and sale of the Shares are and will be exempt from the
registration and prospectus delivery requirements of the Securities Act of 1933,
as amended (the "1933 Act"), and have been registered or qualified (or are
exempt from registration and qualification) under the registration, permit or
qualification requirements of all applicable state securities laws.

            2.15 Business. The Company has all franchises, permits, governmental
licenses and other governmental rights and privileges necessary to permit it to
own its properties and to conduct its present business or its business as
proposed to be conducted, except where the failure to hold such franchises,
permits, governmental licenses or other rights would not have a Material Adverse
Effect on the Company.

            2.16 Brokerage. There are no claims for brokerage commissions or
finder's fees or similar compensation in connection with the transactions
contemplated by this Agreement based on any arrangement made by or on behalf of
the Company and the Company agrees to indemnify and hold Schering harmless
against any damages incurred as a result of any such claim.

            2.17 Insurance. The Company maintains in full force such types and
amounts of insurance issued by issuers of recognized responsibility insuring the
Company, with respect to its liability, workers' compensation, business and
properties, in such amounts and against such losses and risks as are adequate
against risks usually insured against by other corporations, entities or persons
operating similar businesses and properties.

            2.18 Environmental and Safety Laws. To the best of the Company's
knowledge, except with respect to the Portland facility as previously described
to Schering (which to the best knowledge of the Company will not have a Material
Adverse Effect on the Company), the Company is in substantial compliance with
every applicable statute, law or regulation relating to the environment or
occupational health and safety, and no material expenditures are required in
order to comply with any such existing

                                      C-7
<PAGE>   79
statute, law or regulation, except in each case as would not have a Material
Adverse Effect on the Company.

            2.19 Retirement Obligations, etc. The Company does not have any
Employee Benefit Plan, as defined in the Employee Retirement Income Security Act
of 1974 other than as disclosed in the SEC Filings or the Financial Statements.

            2.20 Investment Company. The Company is not an "investment company"
within the meaning of the Investment Company Act of 1940, as amended and will
not, as a result of the transactions contemplated hereby, become an "investment
company."

            2.21 Registration Rights. Except with respect to the obligations of
the Company to register its securities on Form S-8 in connection with its stock
option plans, the Company is not under any contractual obligation to register
any of its currently outstanding securities or any of its securities that may
hereafter be issued.

            2.22 Employees. The Company has complied in all material respects
with all applicable state and federal laws and regulations respecting employment
and employment practices, terms and conditions of employment, wages and hours
and other laws related to employment.

            2.23 Absence of Certain Business Practices. To the best of the
Company's knowledge, none of the Company, or any agent of the Company, or any
other person or entity acting on behalf of or associated with the Company,
acting alone or together, has: (a) received, directly or indirectly, any
rebates, payments, commissions, promotional allowances or any other economic
benefits, regardless of their nature or type, from any customer, supplier,
employee or agent of any customer or supplier, official or employee of any
government (domestic or foreign) or other person; or (b) directly or indirectly,
given or agreed to give any money, gift or similar benefit to any customer,
supplier, employee or agent of any customer or supplier, official or employee of
any government (domestic or foreign), or any political party or candidate for
office (domestic or foreign) or other person or entity who was, is or may be in
a position to help or hinder the business of the Company (or assist the Company
in connection with any actual or proposed transaction) which (i) may subject the
Company to any damage or penalty in any civil, criminal or governmental
litigation or proceeding, (ii) if not continued in the future, may have a
Material Adverse Effect on the Company or subject the Company to suit or penalty
in any private or governmental litigation or proceeding. The Company's existing
accounting controls and procedures are sufficient to cause it to materially
comply with the Foreign Corrupt Practices Act of 1977, as amended ("FCPA"), in
all areas, except as to operations in the former country of Yugoslavia where, to
the best of the Company's knowledge (without the benefit of an internal audit),
it believes that its

                                      C-8
<PAGE>   80
existing accounting controls and procedures are sufficient to cause it to
materially comply with the FCPA.

            2.24 Disclosure. The Company has provided Schering with all the
information that it has requested for deciding whether to purchase the Shares.
Neither the SEC Filings, nor the representations and warranties of the Company
contained in this Agreement and schedules delivered in connection herewith,
contain any untrue statement of a material fact or omit to state a material fact
necessary to make the statements herein or therein, at the time and in light of
the circumstances under which they were made, not misleading.

            3. Representations and Warranties of Schering and Other Agreements.

            3.1 Representations and Warranties. Schering hereby represents and
warrants to the Company that:

            (a) Organization and Corporate Power. Schering is a corporation duly
organized, validly existing and in good standing under the laws of the State of
New Jersey and is qualified to do business as a foreign corporation in each
jurisdiction where failure to so qualify would have a Material Adverse Effect on
Schering. Schering has full power and authority to own its property, to carry on
its business as presently conducted and to carry out the transactions
contemplated hereby.

            (b) Authorization. Schering has full power to execute, deliver and
perform this Agreement and each other agreement entered into by Schering in
connection with this Agreement. Each such agreement has been duly executed and
delivered by Schering and is the legal, valid and, assuming due execution by the
other parties hereto and thereto, binding obligation of Schering, enforceable
against Schering in accordance with its terms, subject to applicable bankruptcy,
insolvency, moratorium, reorganization or similar laws affecting creditors,
rights generally, and to general equitable principles. The execution, delivery
and performance of this Agreement and each other agreement entered into by
Schering in connection with this Agreement, has been duly authorized by all
necessary corporate action of Schering.

            (c) No Governmental Consent or Approval Required. No authorization,
consent, approval or other order of, declaration to, or registration,
qualification, designation or filing with, any federal, state or local
governmental agency or body is required for or in connection with the valid and
lawful authorization, execution and delivery by Schering of this Agreement or
any other agreement entered into by Schering in connection with this Agreement,
and the consummation of the transactions contemplated hereby or thereby.

                                      C-9
<PAGE>   81
            (d) Litigation. Except as disclosed in Schering's filings with the
Securities and Exchange Commission, there is no claim, arbitration, action,
suit, proceeding or investigation pending, or to the best knowledge of Schering,
threatened against Schering, which questions the validity of this Agreement or
any other agreement entered into by Schering in connection with this Agreement
or the right of Schering to enter into any such agreements or to consummate the
transactions contemplated hereby or thereby, or which might result, either
individually or in the aggregate, in any Material Adverse Effect on Schering.
Schering is not a party to, or subject to the provisions of, any order, writ,
injunction, judgment or decree of any court or governmental agency or
instrumentality which would have a Material Adverse Effect on Schering.

            (e) Purchase Entirely for Own Account. The Shares to be received by
Schering will be acquired for investment for Schering's own account, not as a
nominee or agent and not with a view to the distribution of any portion thereof.
Schering has no present intention of selling, granting any participation in, or
otherwise distributing the Shares. Schering does not have any contract,
undertaking, agreement or arrangement with any person to sell, transfer, or
grant participation to such person or to any third person, with respect to any
of the Shares.

            (f) Restrictions on Disposition. Schering covenants that in no event
will it dispose of any of the Shares (other than pursuant to Rule 144
promulgated under the 1933 Act ("Rule 144") or pursuant to a registration
statement filed with the Securities and Exchange Commission (the "SEC") pursuant
to the 1933 Act) unless and until (i) Schering shall have notified the Company
of the proposed disposition and shall have furnished the Company with a
statement of the circumstances surrounding the proposed disposition; and (ii) if
requested by the Company, Schering shall have furnished the Company with an
opinion of Schering's counsel, reasonably satisfactory in form and substance to
the Company and the Company's counsel, to the effect that (a) such disposition
will not require registration under the 1933 Act or (b) appropriate action
necessary for compliance with the 1933 Act and any applicable state, local or
foreign law has been taken. The restrictions on transfer imposed by this Section
3.1(f) shall cease and terminate as to the Shares when: (i) such securities
shall have been effectively registered under the 1933 Act and sold by the holder
thereof in accordance with such registration; or (ii) an opinion of the kind
described in the preceding sentence states that all future transfers of such
securities by the holder thereof would be exempt from registration under the
1933 Act. Each certificate evidencing the Shares shall bear an appropriate
restrictive legend as set forth in Section 3.3 below, except that such
certificate shall not be required to bear such legend after a transfer thereof
if the transfer was made in compliance with Rule 144 or pursuant to a
registration statement or, if the opinion of counsel referred to above is issued
and provides that such legend is not required in order to establish compliance
with any provisions of the 1933 Act.

                                      C-10
<PAGE>   82
            (g) Receipt of Information. Schering has been furnished access to
the business records of the Company and all such additional information and
documents Schering has requested and has been afforded an opportunity to ask
questions of and receive answers from representatives of the Company concerning
the terms and conditions of this Agreement and the purchase of the Shares. (h)
BROKERAGE. There are no claims for brokerage commissions or finder's fees or
similar compensation in connection with the transactions contemplated by this
Agreement based on any arrangement or agreement made by or on behalf of
Schering, and Schering agrees to indemnify and hold the Company harmless against
any damages incurred as a result of any such claims.

            3.2 Further Provisions Regarding Disposition.

            (a) Transfer to Affiliates. Notwithstanding the provisions of
Section 3.1(f) above, no registration statement or opinion of counsel shall be
necessary for a transfer by Schering of the Shares to a subsidiary, shareholder
or affiliate of Schering, if the transferee agrees in writing to be subject to
the terms hereof to the same extent as if such transferee were Schering
hereunder. (b) NEW CERTIFICATES. Whenever the restrictions imposed by Section
3.1(f) shall terminate as herein provided, the holder of the securities as to
which such restrictions have terminated shall be entitled to receive from the
Company, without expense, one or more new certificates not bearing restrictive
legends and not containing any reference to the restrictions imposed by this
Agreement.

            3.3 Legends. Subject to Sections 3.1(f) and 3.2(b), the certificates
evidencing the Shares shall bear substantially the following legends:

            (a) THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN
THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES
UNDER SUCH ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH
REGISTRATION IS NOT REQUIRED OR UNLESS SOLD PURSUANT TO RULE 144 OF SUCH ACT.

            (b) Any legend required by the laws of any other applicable
jurisdiction.

            4. Conditions to Schering's Obligations at Closing.

            4.1 Initial Milestone Closing. The obligation of Schering under
Section 1.1(a) of this Agreement to purchase the Shares at the Initial Milestone
Closing is subject to the fulfillment on or before the Initial Milestone Closing
of each of the following conditions:

                                      C-11
<PAGE>   83
            (a) Representations and Warranties. The representations and
warranties of the Company contained in Section 2 above shall be true on and as
of the Initial Milestone Closing Date with the same effect as though such
representations and warranties had been made on and as of the Initial Milestone
Closing Date.

            (b) Performance. The Company shall have performed and complied with
all agreements, obligations, and conditions contained in this Agreement that are
required to be performed or complied with by it on or before the Initial
Milestone Closing Date.

            (c) Qualifications. All authorizations, approvals, or permits, if
any, of any governmental authority or regulatory body of the United States or of
any state that are required for consummation of the transactions contemplated by
this Agreement shall have been duly obtained, including, without limitation, the
expiration or earlier termination of any notice and waiting period under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and shall be
effective on and as of the Initial Milestone Closing Date.

            (d) Proceedings and Documents. All corporate and other proceedings
in connection with the transactions contemplated at the Initial Milestone
Closing and all documents incident thereto shall be reasonably satisfactory in
form and substance to Schering and Schering's counsel, and they shall have
received all such counterpart original and certified or other copies of such
documents as they may reasonably request.

            (e) Other Agreements. The License Agreement shall have been executed
and delivered by the Company.

            (f) Opinion of Company Counsel. Schering shall have received from
counsel for the Company an opinion addressed to Schering substantially covering
the matters set forth in Sections 2.1, 2.2, 2.3 (as to the due authorization,
valid issuance, full payment and nonassessability of the Shares), 2.12, 2.13 and
2.14 (as to federal law).

            (g) Compliance Certificate. The Chief Executive Officer of the
Company shall deliver to Schering at the Initial Milestone Closing a certificate
certifying that the conditions specified in Sections 4.1(a), 4.1(b), and 4.1(c)
hereof have been fulfilled and stating that there has been no Material Adverse
Change in the Company since January 1, 1995.

            (h) Approval. This Agreement, the License Agreement and the
transactions contemplated hereby and thereby shall have been approved by the
board of directors of Schering.

            (i) [Redacted]

                                      C-12
<PAGE>   84
            4.2 U.S. Milestone Closing. The obligation of Schering under Section
1.1(b) of this Agreement to purchase the Shares at the U.S. Milestone Closing is
subject to the fulfillment of each of the following conditions:

            (a) Representations and Warranties. The representations and
warranties of the Company contained in Section 2 shall be true on and as of the
U.S. Milestone Closing Date with the same effect as though such representations
and warranties had been made on and as of the U.S. Milestone Closing Date.

            (b) Performance. The Company shall have performed and complied with
all agreements, obligations, and conditions contained in this Agreement that are
required to be performed or complied with by it on or before the U.S. Milestone
Closing Date.

            (c) Qualifications. All authorizations, approvals, or permits, if
any, of any governmental authority or regulatory body of the United States or of
any state that are required for consummation of the transactions contemplated by
this Agreement shall have been duly obtained, including, without limitation, the
expiration or earlier termination of any notice and waiting period under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and shall be
effective on and as of the U.S. Milestone Closing Date.

            (d) Proceedings and Documents. All corporate and other proceedings
in connection with the transactions contemplated at the U.S. Milestone Closing
and all documents incident thereto shall be reasonably satisfactory in form and
substance to Schering and Schering's counsel, and they shall have received all
such counterpart original and certified or other copies of such documents as
they may reasonably request.

            (e) Opinion of Company Counsel. Schering shall have received from
counsel for the Company an opinion addressed to Schering substantially covering
the matters set forth in Sections 2.1, 2.2, 2.3 (as to the due authorization,
valid issuance, full payment and nonassessability of the Shares to be purchased
at the U.S. Milestone Closing), 2.12, 2.13 and 2.14 (as to federal law).

            (f) Compliance Certificate. The Chief Executive Officer of the
Company shall deliver to Schering at the U.S. Milestone Closing a certificate
certifying that the conditions specified in Sections 4.2(a), 4.2(b), and 4.2(c)
hereof have been fulfilled and stating that there has been no Material Adverse
Change in the Company since the Initial Closing.

            (g) License Agreement Milestone. The earlier of (i) the Regulatory
Approval of the Product with Minimum Labelling (as defined in the License
Agreement) by the United States Food and Drug Administration, or (ii) the date
on which, following any 12 month period, the royalties for that 12 month period
due to the Company on sales

                                      C-13
<PAGE>   85
in the United States after Regulatory Approval (as defined in the License
Agreement) in the United States exceed [REDACTED], shall have occurred.

            (h) Approval. This Agreement, the License Agreement and the
transactions contemplated hereby and thereby shall have been approved by the
board of directors of Schering.

            4.3 EU Milestone Closing. The obligation of Schering under Section
1.1(c) of this Agreement to purchase the Shares at the EU Milestone Closing is
subject to the fulfillment of each of the following conditions:

            (a) Representations and Warranties. The representations and
warranties of the Company contained in Section 2 shall be true on and as of the
date of the EU Milestone Closing Date with the same effect as though such
representations and warranties had been made on and as of the date of the EU
Milestone Closing Date.

            (b) Performance. The Company shall have performed and complied with
all agreements, obligations, and conditions contained in this Agreement that are
required to be performed or complied with by it on or before the EU Milestone
Closing Date.

            (c) Qualifications. All authorizations, approvals, or permits, if
any, of any governmental authority or regulatory body of the United States or of
any state that are required for consummation of the transactions contemplated by
this Agreement shall have been duly obtained, including, without limitation, the
expiration or earlier termination of any notice and waiting period under the
Hart-Scott-Rodino Antitrust Improvement Act of 1976, as amended, and shall be
effective on and as of the EU Milestone Closing Date.

            (d) Proceedings and Documents. All corporate and other proceedings
in connection with the transactions contemplated at the EU Milestone Closing and
all documents incident thereto shall be reasonably satisfactory in form and
substance to Schering and Schering's counsel, and they shall have received all
such counterpart original and certified or other copies of such documents as
they may reasonably request.

            (e) Opinion of Company Counsel. Schering shall have received from
counsel for the Company an opinion addressed to Schering substantially covering
the matters set forth in Sections 2.1, 2.2, 2.3 (as to the due authorization,
valid issuance, full payment and nonassessability of the Shares to be purchased
at the EU Milestone Closing), 2.12, 2.13 and 2.14 (as to federal law).

            (f) Compliance Certificate. The Chief Executive Officer of the
Company shall deliver to Schering at the EU Milestone Closing a certificate
certifying that the conditions specified in Sections 4.3(a), 4.3(b), and 4.3(c)
hereof have been fulfilled and

                                      C-14
<PAGE>   86
stating that there has been no Material Adverse Change in the Company, since the
Initial Closing.

            (g) License Agreement Milestone. The Regulatory Approval of the
Product in the European Union (including, as applicable, the CPMP or the
European Agency for the Evaluation of Medicinal Products) with Minimum Labelling
(as defined in the License Agreement) in at least [REDACTED] of the [REDACTED],
shall have occurred.

            (h) Approval. This Agreement, the License Agreement and the
transactions contemplated hereby and thereby shall have been approved by the
board of directors of Schering.

            5. Conditions of the Company's Obligations at Closing.

            5.1 Initial Milestone Closing. The obligations of the Company under
Section 1.1(a) of this Agreement are subject to the fulfillment on or before the
Initial Milestone Closing of each of the following conditions:

            (a) Representations and Warranties. The representations and
warranties of Schering contained in Section 3 shall be true on and as of the
Initial Milestone Closing Date with the same effect as though such
representations and warranties had been made on and as of the Initial Milestone
Closing Date.

            (b) Performance. Schering shall have performed and complied with all
agreements, obligations and conditions contained in this Agreement that are
required to be performed or complied with by it on or before the Initial
Milestone Closing Date.

            (c) Qualifications. All authorizations, approvals, or permits, if
any, of any governmental authority or regulatory body of the United States or of
any state that are required for consummation of the transactions contemplated by
this Agreement shall have been duly obtained, including, without limitation, the
expiration or earlier termination of any notice and waiting period under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and shall be
effective on and as of the Initial Milestone Closing Date.

            (d) Other Agreements. The License Agreement shall have been executed
and delivered by Schering-Plough Ltd.

            (e) Opinion of Schering Counsel. The Company shall have received
from counsel for Schering an opinion addressed to the Company covering the
matters set forth in Sections 3.1(a), (b), (c) and (d).

                                      C-15
<PAGE>   87
            (f) Compliance Certificate. An officer of Schering shall deliver to
the Company at the Closing a certificate certifying that the conditions
specified in Sections 5.1(a), 5.1(b), and 5.1(c) hereof have been fulfilled.

            (g) Approval. This Agreement, the License Agreement and the
transactions contemplated hereby and thereby shall have been approved by the
board of directors of the Company.

            5.2 U.S. Milestone Closing. The obligations of the Company under
Section 1.1(b) of this Agreement are subject to the fulfillment on or before the
U.S. Milestone Closing of each of the following conditions:

            (a) Representations and Warranties. The representations and
warranties of Schering contained in Section 3 shall be true on and as of the
U.S. Milestone Closing Date with the same effect as though such representations
and warranties had been made on and as of the U.S. Milestone Closing Date.

            (b) Performance. Schering shall have performed and complied with all
agreements, obligations and conditions contained in this Agreement that are
required to be performed or complied with by it on or before the U.S. Milestone
Closing Date.

            (c) QUALIFICATIONS. ALL AUTHORIZATIONS, APPROVALS, OR PERMITS, IF
ANY, OF ANY GOVERNMENTAL AUTHORITY OR REGULATORY BODY OF THE UNITED STATES OR OF
ANY STATE THAT ARE REQUIRED FOR CONSUMMATION OF THE TRANSACTIONS CONTEMPLATED BY
THIS AGREEMENT, SHALL HAVE BEEN DULY OBTAINED, INCLUDING, WITHOUT LIMITATION,
THE EXPIRATION OR EARLIER TERMINATION OF ANY NOTICE AND WAITING PERIOD UNDER THE
HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976, AS AMENDED, AND SHALL BE
EFFECTIVE ON AND AS OF THE U.S. MILESTONE CLOSING DATE.

            5.3 EU Milestone Closing. The obligations of the Company under
Section 1.1(c) of this Agreement are subject to the fulfillment on or before the
EU Milestone Closing of each of the following conditions:

            (a) Representations and Warranties. The representations and
warranties of Schering contained in Section 3 shall be true on and as of the EU
Milestone Closing Date with the same effect as though such representations and
warranties had been made on and as of the date of the EU Milestone Closing Date.

            (b) Performance. Schering shall have performed and complied with all
agreements, obligations and conditions contained in this Agreement that are
required to be performed or complied with by it on or before the EU Milestone
Closing Date.

                                      C-16
<PAGE>   88
            (c) Qualifications. All authorizations, approvals, or permits, if
any, of any governmental authority or regulatory body of the United States or of
any state that are required for consummation of the transactions contemplated by
this Agreement, shall have been duly obtained, including, without limitation,
the expiration or earlier termination of any notice and waiting period under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and shall be
effective on and as of the EU Milestone Closing Date.

            6. Registration of Common Stock; Covenants of the Company; Other
Agreements.

            6.1 Definitions. Unless the context otherwise requires, the terms
defined in this Section 6 shall have the meanings herein specified for all
purposes of this Agreement, applicable to both the singular and plural forms of
any of the terms herein defined.

            "Board" means the Board of Directors of the Company.

            "HOLDER" of any security means the record or beneficial owner of
such security or any permitted assignee thereof.

            "Person" means any natural person, corporation, trust, association,
company, partnership, joint venture or other entity or any government,
governmental agency, instrumentality or political subdivision.

            The terms "Register", "Registered" and "Registration" refer to a
registration effected by preparing and filing a registration statement in
compliance with the 1933 Act, and the declaration for ordering of the
effectiveness of such registration statement.

            "Registrable Securities" means (i) the shares of Common Stock sold
pursuant to this Agreement and (ii) any Common Stock issued or issuable (either
directly or upon the conversion of or exercise of any warrant, right or other
security) with respect to the Common Stock referred to in clause (i) above by
way of a stock dividend or stock split or in connection with a combination of
shares, reclassification, recapitalization, merger or consolidation or
reorganization; provided, however that such shares of Common Stock shall only be
treated as Registrable Securities if and so long as they have not been (x) sold
to or through a broker or dealer or underwriter in a public distribution or a
public securities transaction, or (y) sold in a transaction exempt from the
registration and prospectus delivery requirements of the 1933 Act pursuant to
Rule 144 thereunder so that all the transfer registrations and restrictive
legends with respect to such Common Stock are removed upon the consummation of
such sale and the Company receives an opinion of counsel for the Company (with a
copy to the seller of such Common Stock), which shall be in form and content
reasonably satisfactory to the Company, to the effect

                                      C-17
<PAGE>   89
that such Common Stock in the hands of the purchaser is freely transferable
without restriction or registration under the 1933 Act in any public or private
transaction.

            6.2   Demand Registration.

            (a) If and whenever the Company shall receive at any time after
[REDACTED] after the earlier to occur of the Initial Milestone Closing Date, the
U.S. Milestone Closing Date or the EU Milestone Closing Date hereunder, a
written request therefor from the Holders of at least 30 percent of the
Registrable Securities then outstanding, the Company agrees to prepare and file
promptly a registration statement under the 1933 Act covering the shares of
Registrable Securities which are the subject of such request and agrees to use
its best efforts to cause such registration statement to become effective as
expeditiously as possible. Upon the receipt of such request, the Company agrees
to give prompt written notice to all Holders of Registrable Securities that such
registration is to be effected. The Company agrees to include in such
registration statement such shares of Registrable Securities for which it has
received a written request to register such shares by the Holders thereof within
twenty (20) days after the receipt by the Holders of the written notice from the
Company.

            (b) The Company shall be obligated to prepare, file and cause to
become effective only [REDACTED] registration statements pursuant to this
Section 6.2. A registration required to be effected by the Company pursuant to
this Section 6.2 shall not be deemed to have been effected even though a
registration statement with respect thereto has become effective (i) if, after
it has become effective, such registration is interfered with by any stop order,
injunction, or other order or requirement of the SEC or other governmental
agency or court, for any reason not attributable to the Holders initiating the
registration request hereunder (the "Initiating Holders") with respect to such
registration statement, and has not thereafter become effective or (ii) if the
conditions to closing specified in the underwriting agreement, if any, entered
into in connection with such registration are not satisfied or waived, other
than by reason of a failure on the part of the Initiating Holders with respect
to such registration statement.

            (c) If the Initiating Holders intend to distribute the Registrable
Securities covered by their request by means of an underwriting, they agree to
provide the Company with the name of the managing underwriter or underwriters
(the "Managing Underwriter") that the Initiating Holders holding a majority of
the Shares to be included in the registration propose to employ, as part of
their request made pursuant to this Section 6.2, and the Company agrees to
include such information in its written notice referred to in Section 6.2(a). In
such event, the right of any Holder to registration pursuant to this Section 6.2
shall be conditioned upon such Holder's participation in such underwriting and
the inclusion of such Holder's Registrable Securities in the underwriting
(unless otherwise mutually agreed by the Holders of a majority of the shares of

                                      C-18
<PAGE>   90
Registrable Securities to be included in such registration and such Holder). All
Holders proposing to distribute their securities through such underwriting agree
to enter into (together with the Company) an underwriting agreement with the
underwriter or underwriters elected for such underwriting, in the manner set
forth above, provided that such underwriting agreement is in customary form and
is reasonably acceptable to the Holders of a majority of the shares of
Registrable Securities to be included in such registration.

            (d) Notwithstanding the foregoing, if the Managing Underwriter of an
underwritten distribution advises the Company and the Holders of Registrable
Securities participating in such registration in writing that in its good faith
judgment the number of shares of Registrable Securities and the other securities
requested to be included in such registration exceeds the number of shares of
Registrable Securities and the other securities which can be sold in such
offering, then (i) the other securities so requested to be included in such
registration shall initially be reduced and the number of shares of Registrable
Securities so requested to be included in such registration shall subsequently
be reduced, together to that number of shares which in the good faith judgment
of the Managing Underwriter can be sold in such offering and (ii) the reduced
number of Registrable Securities to be included in the underwriting shall be
allocated pro rata among all Holders of Registrable Securities. Those
Registrable Securities which are excluded from the underwriting by reason of the
Managing Underwriter's marketing limitation shall not be included in such
registration and shall be withheld from the market by the Holders thereof for a
period not in excess of 120 days, which the Managing Underwriter reasonably
determines is necessary to effect the underwritten public offering.

            (e) Notwithstanding any other provision of this Section 6.2, if
within ten (10) days following receipt of a request to file a demand
registration statement under this Section 6.2, the Company shall furnish to
Schering and the Holders a certificate signed by the Chief Executive Officer of
the Company stating that in the good faith judgment of the Board of the Company
it would be seriously detrimental to the Company or its shareholders for a
registration statement to be filed in the near future, then the Company's
obligation to file a registration statement under this Section 6.2 shall be
deferred for a period not to exceed three (3) months; provided, however, that
the Company shall not obtain such a deferral to file any registration statement
under this Section 6.2 more than once in any 12-month period.

            6.3 "Piggyback" Registration

            (a) Each time the Company shall determine to file a registration
statement under the 1933 Act (other than pursuant to Section 6.2 hereof and
other than on Form S-4, S-8 or a registration statement on Form S-1 covering
solely any employee benefit plan) in connection with the proposed offer and sale
for money of any of its securities either for its

                                      C-19
<PAGE>   91
own account or on behalf of any other security holder, the Company agrees to
give prompt written notice of its determination to all Holders of Registrable
Securities. Upon the written request of a Holder of any shares of Registrable
Securities given within twenty (20) days after the receipt of such written
notice from the Company, the Company agrees to cause all such Registrable
Securities, the Holders of which have so requested registration thereof, to be
included in such registration statement and to use its best efforts to cause
such registration statement to become effective under the 1933 Act, all to the
extent requisite to permit the sale or other disposition by the prospective
seller or sellers of the Registrable Securities to be so registered. In the
event that the proposed registration by the Company is, in whole or in part, an
underwritten public offering of securities of the Company, any request pursuant
to this Section 6.3(a) to register Registrable Securities may specify that such
securities are to be included in the underwriting (i) on the same terms and
conditions as the shares of Common Stock, if any, otherwise being sold through
underwriters, under such registration, or (ii) on terms and conditions
comparable to those normally applicable to offerings of Common Stock in
reasonably similar circumstances in the event that no shares of Common Stock
other than Registrable Securities are being sold through underwriters in such
registration.

            (b) If the registration of which the Company gives written notice
pursuant to Section 6.3(a) is for an underwritten public offering, the Company
agrees to so advise the Holders as a part of its written notice. In such event
the right of any Holder to registration pursuant to this Section 6.3 shall be
conditioned upon such Holder's participation in such underwriting and the
inclusion of such Holder's Registrable Securities in the underwriting to the
extent provided herein. All Holders proposing to distribute their Registrable
Securities through such underwriting agree to enter into (together with the
Company and the other Holders distributing their securities through such
underwriting) an underwriting agreement with the underwriter or underwriters
selected for such underwriting by the Company.

            (c) Notwithstanding any other provision of this Section 6.3, if the
Managing Underwriter of an underwritten distribution advises the Company and the
Holders of the Registrable Securities requesting participation in such
registration in writing that in its good faith judgment the number of shares of
Registrable Securities and the other securities requested to be registered under
this Section 6.3 exceeds the number of shares of Registrable Securities and
other securities which can be sold in such offering, then (i) the number of
shares of Registrable Securities and other securities so requested to be
included in the offering shall be reduced to that number of shares which in the
good faith judgment of the Managing Underwriter can be sold in such offering
(except for shares to be issued by the Company in a public offering, which shall
have priority over the Registrable Securities), and (ii) such reduced number of
shares shall be allocated among all participating Holders of Registrable
Securities and holders of other securities in proportion, as nearly as
practicable, to the respective number of shares of Registrable

                                      C-20
<PAGE>   92
Securities and other securities requested to be registered held by such Holders
at the time of filing the registration statement. All Registrable Securities and
other securities which are excluded from the underwriting by reason of the
Managing Underwriters's marketing limitation and all other Registrable
Securities not originally requested to be so included shall not be included in
such registration and shall be withheld from the market by the Holders thereof
for a period, not in excess of 120 days, which the Managing Underwriter
reasonably determines is necessary to effect the underwritten public offering.

            6.4 Registration Expenses.

            (a) The Company shall pay all expenses incurred in effecting the
registration of Registrable Securities pursuant to Section 6 including, without
limitation, all federal and state registration, qualification and filing fees,
printing expenses, fees and disbursements of counsel for the Company, reasonable
fees and disbursements of one counsel for the participating Holders together,
blue sky fees and expenses, and the expense of any special audits incident to or
required by any such registration, but not including underwriting discounts,
commissions and expenses.

            (b) Notwithstanding the foregoing, in the event that a registration
pursuant to Section 6.2 is requested by the Initiating Holders and such request
is withdrawn prior to the filing of a registration statement by the Company, or
such Holders cause the Company to withdraw a registration statement prior to its
effectiveness, then either (i) the Initiating Holders and other Holders
requesting inclusion of their shares in such registration shall bear pro rata
all fees, costs and expenses of the registration and preparation of the
registration statement or (ii) such requested registration shall be deemed to be
one of the registrations the Company is required to effect pursuant to Section
6.2 hereof; provided however, if at the time of the withdrawal, the Initiating
Holders and the other Holders have learned of a Material Adverse Change with
respect to the Company which was not known to such Holders at the time of their
request, then such Holders shall not be required to pay any of such registration
expenses and shall retain their rights pursuant to Section 6.2.

            6.5 Registration Procedures. If and whenever the Company is required
by the provisions of Section 6 to effect the registration of Registrable
Securities under the 1933 Act, the Company will, as expeditiously as possible:

            (a) prepare and file with the SEC a registration statement which
includes the Registrable Securities and use its best efforts to cause such
registration statement to become and remain effective until the distribution
described in the registration statement has been completed;

            (b) prepare and file with the SEC such amendments and supplements to
such registration statement and the prospectus used in connection therewith as
may be

                                      C-21
<PAGE>   93
necessary to keep such registration statement effective and to comply with the
provisions of the 1933 Act with respect to the sale or other disposition of
Registrable Securities covered by such registration statement whenever a Holder
shall desire to sell or otherwise dispose of the same;

            (c) furnish to each participating Holder (and to each underwriter,
if any, of Registrable Securities) such number of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the
1933 Act, and such other documents, as such Holder may reasonably request in
order to facilitate the public sale or other disposition of the Registrable
Securities;

            (d) use its best efforts to register or qualify the Registrable
Securities covered by such registration statement under such state securities or
blue sky laws of such jurisdiction as each participating Holder shall reasonably
request and do any and all other acts and things which may be necessary under
such securities or blue sky laws to enable such Holder to consummate the public
sale or other disposition of the Registrable Securities in such jurisdictions,
except that the Company shall not for any purpose be required to consent
generally to service of process or qualify to do business as a foreign
corporation in any jurisdiction wherein it is not so qualified;

            (e) before filing the registration statement or prospectus or
amendments or supplements thereto, furnish to counsel selected by the
participating Holders copies of such documents proposed to be filed which shall
be subject to the reasonable approval of such counsel;

            (f) enter into and perform its obligations under an underwriting
agreement, in usual and customary form, with the Managing Underwriter of such
offer;

            (g) notify the participating Holders at any time when a prospectus
relating to any Registrable Securities covered by such registration statement is
required to be delivered under the 1933 Act, of the happening of any event as a
result of which the prospectus included in such registration statement, as then
in effect, includes an untrue statement of a material fact or omits to state a
material fact required to be stated therein or necessary to make the statements
therein not misleading in light of the circumstances then existing and promptly
file such amendments and supplements as may be necessary so that, as thereafter
delivered to such Holders of such Registrable Securities, such prospectus shall
not include an untrue statement of a material fact or omit to state a material
fact required to be stated therein or necessary to make the statements therein
not misleading in light of the circumstances then existing and use its best
efforts to cause each such amendment and supplement to become effective;

            (h) furnish at the request of the participating Holders on the date
that such Registrable Securities are delivered to the underwriters for sale in
connection with a

                                      C-22
<PAGE>   94
registration pursuant to Section 6 (i) an opinion addressed to the underwriters,
if any, and to such Holders, dated such date, of the counsel representing the
Company for purposes of such registration in form and substance as is
customarily given by company counsel to the underwriters in an underwritten
public offering, and (ii) a letter dated such date addressed to the
underwriters, if any, and to such Holders, from the independent certified public
accountants of the Company, in form and substance as is customarily given by
independent certified public accountants to underwriters in an underwritten
public offering; and

            (i) use its best efforts to cause all such Registrable Securities to
be listed on the securities exchange, if any, or the NMS, on which the Common
Stock is then listed.

            6.6 Form S-3 Registration. In case the Company shall at any time
after [REDACTED] after the earlier to occur of the Initial Milestone Closing
Date, the U.S. Milestone Closing Date or the EU Milestone Closing Date
hereunder, receive from any Holder or Holders a written request or requests that
the Company effect a registration on Form S-3 and any related qualification or
compliance with respect to all or a part of the Registrable Securities owned by
such Holder or Holders, the Company shall:

            (a) promptly give written notice of the proposed registration, and
any related qualification or compliance, to all other Holders; and

            (b) as soon as practicable, file a registration statement and effect
such registration and all such qualifications and compliances as may be so
requested and as would permit or facilitate the sale and distribution of all or
such portion of such Holder's or Holders' Registrable Securities as are
specified in such request, together with all or such portion of the Registrable
Securities of any other Holder or Holders joining in such request as are
specified, in a written request given within 15 business days after receipt of
such written notice from the Company, provided, however, that the Company shall
not be obligated to effect any such registration, qualification or compliance
pursuant to this Section 6.6: (i) if Form S-3 is not available for such offering
by the Holders; (ii) if the Holders, together with the holders of any other
securities of the Company entitled to inclusion in such registration, propose to
sell Registrable Securities and such other securities (if any) at an aggregate
price to the public (net of any underwriters' discounts or commissions) of less
than Five Hundred Thousand Dollars ($500,000); (iii) if the Company shall
furnish to the Holders a certificate signed by the President or Chief Executive
Officer of the Company stating that in the good faith judgment of the Board, it
would be seriously detrimental to the Company and its stockholders for such Form
S-3 Registration to be effected at such time, in which event the Company shall
have the right to defer the filing of the Form S-3 Registration Statement for a
period of not more than 60 days after receipt of the request of the Holder or
Holders under this Section 6.6; provided,

                                      C-23
<PAGE>   95
however, that the Company shall not utilize this right more than once in any
12-month period; (iv) if the Company has, within the 12-month period preceding
the date of such request, already effected two registrations on Form S-3 for the
Holders pursuant to this Section 6.6; or (v) in any particular jurisdiction in
which the Company would be required to qualify to do business or to execute a
general consent to service of process in effecting such registration,
qualification or compliance.

            (c) Registrations effected pursuant to this Section 6.6 shall be
counted as demands for purposes of the number of registrations effected pursuant
to Section 6.2.

            6.7 Indemnification. In the event Registrable Securities are
registered pursuant to this Section 6:

            (a) To the extent permitted by law, the Company will indemnify and
hold harmless each Holder of Registrable Securities which are included in a
registration statement pursuant to the provisions of this Agreement and any
underwriter (within the meaning of the 1933 Act) with respect to the Registrable
Securities, and each officer, director, employee and agent thereof and each
person, if any, who otherwise controls such Holder or underwriter (within the
meaning of the 1933 Act), against any losses, claims, damages, expenses or
liabilities, joint or several, to which they may become subject under the 1933
Act, the Securities Exchange Act of 1934, as amended (the "Exchange Act") or
other federal or state law, or otherwise, insofar as such losses, claims,
damages, expenses or liabilities (or actions in respect thereof) arise out of or
are based upon any untrue or allegedly untrue statement of any material fact
contained in the registration statement for the Registrable Securities,
including any preliminary prospectus or final prospectus contained therein or
any amendments or supplements thereto, or any document incident to the
registration or qualification of any Registrable Securities, or arise out of or
are based upon the omission or alleged omission to state therein a material fact
required to be stated therein or allegedly necessary to make the statements
therein not misleading or arise out of any violation or alleged violation by the
Company of the 1933 Act, the Exchange Act, any state securities law or any rule
or regulation promulgated under the 1933 Act, the Exchange Act or any state
securities law; and will reimburse such Holder, any underwriter, officer,
director, employee, agent or controlling person for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any
such loss, claim, damage, liability or action; provided, however, that the
indemnity agreement contained in this Section 6.7(a) shall not apply to amounts
paid in settlement of any such loss, claim, damage, expense, liability or action
if such settlement is effected without the written consent of the Company, which
shall not be unreasonably withheld, nor shall the Company be liable under this
Section 6.7(a) to such Holder, such underwriter, officer, director, employee,
agent or controlling person for any such loss, claim, damage, expense, liability
or action to the extent that it arises out of, or is based upon, an untrue
statement or allegedly untrue statement or omission or alleged omission

                                      C-24
<PAGE>   96
made in connection with such registration statement, preliminary prospectus,
final prospectus, or amendments or supplements thereto, in reliance upon and in
conformity with information furnished in writing expressly for use in connection
with such registration by such Holder, such underwriter, officer, director,
employee, agent or such controlling person.

            (b) To the extent permitted by law, each Holder of Registrable
Securities which are included in a registration statement pursuant to the
provisions of this Agreement will indemnify and hold harmless the Company, each
of its employees, agents, directors and officers, each person, if any, who
otherwise controls the Company (within the meaning of the 1933 Act), and any
underwriter (within the meaning of the 1933 Act) against any losses, claims,
damages, expenses or liabilities to which the Company or any such person or
underwriter may become subject under the 1933 Act, the Exchange Act or other
federal or state law or otherwise, insofar as such losses, claims, damages,
expenses or liabilities (or actions in respect thereof) arise out of, or are
based upon any untrue or allegedly untrue statement of any material fact
contained in a registration statement for the Registrable Securities, including
any preliminary prospectus or final prospectus contained therein or any
amendments or supplements thereto, or any document incident to the registration
or qualification of any Registrable Securities, or arise out of or are based
upon the omission or alleged omission to state therein a material fact required
to be stated therein or allegedly necessary to make the statements therein not
misleading; in each case to the extent that such untrue statement or allegedly
untrue statement or omission or alleged omission was made in such registration
statement, preliminary prospectus, or amendments or supplements thereto, in
reliance upon and in conformity with information furnished in writing by such
Holder expressly for use in connection with such registration; provided,
however, that the indemnity agreement contained in this Section 6.7(b) shall not
apply to amounts paid in settlement of any such loss, claim, damage, expense,
liability or action if such settlement is effected without the written consent
of such Holder, which shall not be unreasonably withheld; and such Holder will
reimburse the Company or any such person or underwriter for any legal or other
expenses reasonably incurred by the Company or any such person or underwriter in
connection with investigating or defending such loss, claim, damage, liability,
expense or action.

            (c) Promptly after receipt by an indemnified party under this
Section 6.7 of notice of the commencement of any action, such indemnified party
will, if a claim in respect thereof is to be made against any indemnifying party
under this Section 6.7, notify the indemnifying party in writing of the
commencement thereof and generally summarize such action. The indemnifying party
shall have the right to participate in and to assume the defense thereof with
counsel mutually satisfactory to the parties. An indemnifying party shall not
have the right to direct the defense of such an action on behalf of an
indemnified party if such indemnified party has reasonably concluded that there
may be

                                      C-25
<PAGE>   97
defenses available to it that are different from or additional to those
available to the indemnifying party; provided, however, that in such event, the
indemnifying party shall bear the fees and expenses of only one (1) separate
counsel for all indemnified parties. The failure to notify an indemnifying party
promptly of the commencement of any such action if prejudicial to the ability to
defend such action, shall relieve such indemnifying party of any liability to
the indemnified party under this Section 6.7, but the omission so to notify the
indemnifying party will not relieve such party of any liability that such party
may have to any indemnified party otherwise than under this Section 6.7.

            (d) To the extent permitted by law, the indemnification provided for
under this Section 6.7 will remain in full force and effect regardless of any
investigation made by or on behalf of the indemnified party or any officer,
director or controlling person (within the meaning of the 1933 Act) of such
indemnified party and will survive the transfer of any securities.

            (e) If for any reason the foregoing indemnity is unavailable to, or
is insufficient to hold harmless an indemnified party, then the indemnifying
party shall contribute to the amount paid or payable by the indemnified party as
a result of such losses, claims, damages, expenses or liabilities (i) in such
proportion as is appropriate to reflect the relative benefits received by the
indemnifying party on the one hand and the indemnified party on the other or
(ii) if the allocation provided by clause (i) above is not permitted by
applicable law, or provides a lesser sum to the indemnified party than the
amount representing such proportion as is appropriate to reflect not only the
relative benefits received by the indemnifying party on the one hand and the
indemnified party on the other but also the relative fault of the indemnifying
party and the indemnified party as well as any other relevant equitable
considerations. Notwithstanding the foregoing, no underwriter, if any, shall be
required to contribute any amount in excess of the amount by which the total
price at which the securities underwritten by it and distributed to the public
were offered to the public exceeds the amount of any damages which underwriter
has otherwise been required to pay by reason of such untrue or alleged untrue
statement or omission or alleged omission. No person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the 1933 Act) shall be
entitled to contribution from any person who was not guilty of such fraudulent
misrepresentation. The obligation of any underwriters to contribute pursuant to
this Section 6.7(e) shall be several in proportion to their respective
underwriting commitments and not joint.

            6.8 Reports Under Exchange Act. With a view to making available to
the Holders the benefits of Rule 144 promulgated under the 1933 Act and any
other rule or regulation of the SEC that may at any time permit a Holder to sell
Registrable Securities to the public without registration, and with a view to
making it possible for any such Holder to register the Registrable Securities
pursuant to a registration on Form S-3, the Company agrees to:

                                      C-26
<PAGE>   98
            (a) make and keep public information available at all times, as
those terms are understood and defined in Rule 144;

            (b) take such action as is necessary to enable a Holder to utilize
Form S-3 for the sale of Registrable Securities;

            (c) file with the SEC in a timely manner all reports and other
documents required of the Company under the 1933 Act and the Exchange Act; and

            (d) furnish to a Holder owning any Registrable Securities upon
request (i) a written statement by the Company that it has complied with the
reporting requirements of Rule 144, the 1933 Act and the Exchange Act, or that
it qualifies as a registrant whose Registrable Securities may be resold pursuant
to Form S-3 (at any time after it so qualifies), (ii) a copy of the most recent
annual or quarterly report of the Company and such other reports and documents
so filed by the Company, and (iii) such other information as may be reasonably
required in availing any Holder of Registrable Securities of any rule or
regulation of the SEC which permits the selling of any such Registrable
Securities without registration or pursuant to such form.

            6.9 Transferability. The right to cause the Company to register
Registrable Securities granted by the Company to the Holders under this
Agreement may be assigned by any Holder to a transferee or assignee of any
Registrable Securities, provided that the Company must receive written notice
prior to or at the time of said transfer, stating the name and address of said
transferee or assignee and identifying the securities with respect to which such
rights are being assigned. The limitations set forth in this Section 6 with
respect to registration rights shall apply to all transferees or assignees of
Registrable Securities.

            6.10 Cross-Default. The termination, expiration or failure of the
License Agreement to become effective for any reason other than a breach thereof
by Schering-Plough Ltd. or any of its affiliates shall terminate this Agreement
as of the date of such termination (or, if Schering-Plough Ltd. terminates the
License Agreement without cause, as of the date Schering-Plough Ltd. provides
Company with notice of such termination). In the event of the termination of the
License Agreement by the Company upon the breach thereof by Schering-Plough,
Ltd., then such breach shall be deemed to be a material breach of this Agreement
and this Agreement shall also terminate. Any such termination shall be without
prejudice to any other rights the Company may have. The Company's obligations
and the rights of Schering and other Holders of Registrable Securities under
this Article 6 shall survive any termination of this Agreement with respect to
Registrable Securities owned by Schering and other Holders as of the date of
such termination.

                                      C-27
<PAGE>   99
            6.11 Limitation of Liability. With respect to any claim by one party
against the other arising out of the performance or failure of performance of
the other party under this Agreement, the parties expressly agree that the
liability of such party to the other party for such breach shall be limited
under this Agreement or otherwise at law or equity to direct damages only and in
no event shall a party be liable for, punitive, exemplary or consequential
damages.

            7. Miscellaneous.

            7.1 Survival of Warranties. The warranties, representations,
agreements, covenants and undertakings of the Company or Schering contained in
or made pursuant to this Agreement shall survive the execution and delivery of
this Agreement and the Initial Closing, the U.S. Milestone Closing and the EU
Milestone Closing, as the case may be, and shall in no way be affected by an
investigation of the subject matter thereof made by or on behalf of Schering or
the Company.

            7.2 Incorporation by Reference. All schedules appended to this
Agreement are herein incorporated by reference and made a part hereof.

            7.3 Parties in Interest. All terms, covenants, agreements,
representations, warranties and undertakings in this Agreement made by and on
behalf of any of the parties hereto shall bind and inure to the benefit of the
respective successors and assigns of the parties hereto (including transferees
of any Shares), subject to Section 6.9 hereof.

            7.4 Amendments and Waivers. Changes in or additions to this
Agreement may be made or compliance with any term, covenant, agreement,
condition or provision set forth herein may be omitted or waived, only upon the
written consent of the Company and Schering.

            7.5 Governing Law. This Agreement shall be deemed a contract made
under the laws of the State of New Jersey and, together with the rights or
obligations of the parties hereunder, shall be construed under and governed by
the laws of such State.

            7.6 Notices. All notices, requests, consents and demands shall be in
writing and shall be deemed given when (i) personally delivered, (ii) mailed in
a registered or certified envelope, postage prepaid or (iii) sent by Federal
Express or another nationally recognized overnight delivery service (paid by
sender):

to the Company at:

                          ICN Pharmaceuticals, Inc.
                          ICN Plaza

                                      C-28
<PAGE>   100
                          330 Hyland Avenue
                          Costa Mesa, CA 92626
                          Attention: President
                          Facsimile Number: (714) 641-7276

or to Schering at:

                          Schering-Plough Corporation
                          2000 Galloping Hill Road
                          Kenilworth, NJ 07033
                          Attention: President
                          Facsimile Number: (908) 298-5379

            or such other address as may be furnished in writing by a party
to the other party hereto.

            7.7 Counterparts. This Agreement may be executed in counterparts,
all of which together shall constitute one and the same instrument.

            7.8 Effect of Headings. The section and paragraph headings herein
are for convenience only and shall not affect the construction hereof.

            7.9 Entire Agreement. This Agreement, the Supply Agreement and the
schedules hereto and thereto constitute the entire agreement between the Company
and Schering with respect to the subject matter hereof. There are no
representations, warranties, covenants or undertakings with respect to the
subject matter hereof other than those expressly set forth herein. This
Agreement supersedes all prior agreements between the parties with respect to
the Shares purchased hereunder and the subject matter hereof.

            7.10 Publicity. No party shall originate any publicity, news
release, or other announcement, written or oral, relating to this Agreement, or
to performance hereunder or the existence of an arrangement between the parties
hereto without the prior written approval of the other. Nothing contained herein
shall prevent any party from at any time furnishing any information to any
governmental authority which it is by law so obligated to disclose or from
making any disclosure which its counsel deems necessary or advisable in order to
fulfill such party's disclosure obligations under applicable law or the rules of
the New York Stock Exchange.

            7.11 Severability. The invalidity or unenforceability of any
provision hereof shall in no way affect the validity or enforceability of any
other provision.

            IN WITNESS WHEREOF, this Agreement has been executed as of the date
first above written, by the duly authorized representatives of parties hereto.

                                      C-29
<PAGE>   101
                                    ICN PHARMACEUTICALS, INC.

                                    By: /s/ DAVID C.  WATT
                                        --------------------------
                                        Name:  David C.  Watt
                                        Title: Executive Vice President,
                                               General Counsel and Corporate
                                               Secretary

                                     SCHERING-PLOUGH CORPORATION

                                    By: /s/ David Poorvin, Ph.D.
                                        --------------------------
                                        Name:  David Poorvin, Ph.D.
                                        Title: Authorized Signatory

                                      C-30
<PAGE>   102
                                  SCHEDULE 2.13

            In the Company's Form 10-Q for the period ended March 31, 1995,
under Item 3, "Legal Proceedings," reference was made to various actions,
including securities class actions (the "Securities Actions") and shareholder
derivative actions (the "Federal Derivative Actions") filed in February and
March 1995 in the United States District Court for the Central District of
California, alleging, INTER ALIA, that the Company and certain of its officers
and directors had made various deceptive and untrue statements of material fact
and omitted to state material facts in connection with information it received
from the U.S. Food and Drug Administration ("FDA") regarding the Company's New
Drug Application ("NDA") for the use of Virazole(R) for the treatment of chronic
hepatitis C (the "Hepatitis C NDA"), and that certain officers of the Company
had allegedly engaged in illegal insider trading.

            By order dated May 2, 1995, the Securities Actions were consolidated
and directed to be coordinated with the related Federal Derivative Actions.
PURSUANT TO THE TIME SCHEDULES SET FORTH IN THE MAY 2 ORDER, ON JUNE 15 AN
AMENDED CONSOLIDATED COMPLAINT WAS SERVED IN THE SECURITIES ACTIONS, AND AN
AMENDED CONSOLIDATED COMPLAINT WAS SERVED IN THE FEDERAL DERIVATIVE ACTIONS.
PURSUANT TO THE ORDER, DEFENDANTS HAVE UNTIL AUGUST 1 TO ANSWER OR MOVE WITH
RESPECT THERETO.

            In May 1995, an additional securities class action was filed against
the Company and its chairman in the Central District of California alleging
that, INTER ALIA, the proxy materials and prospectus prepared in connection with
the merger of ICN Pharmaceuticals, Inc. ("Old ICN"), SPI Pharmaceuticals, Inc.
("SPI"), Viratek, Inc. and ICN Biomedicals, Inc. ("Biomedicals"), effective
November 10, 1994 ("the Merger"), contained false and misleading information
regarding the potential approval by the FDA of Virazole(R) for the Hepatitis C
indication, and that defendants had therefore established an excessive value for
the shares of Viratek in setting the exchange ratios for the four companies in
connection with the Merger. Plaintiff further alleges that the Company's
chairman had engaged in illegal insider trading of the Company's common stock.
On behalf of a purported class of individuals who exchanged their shares of Old
ICN, SPI or Biomedicals for newly issued shares of New ICN, plaintiff seeks
damages and related relief. Counsel for defendants has agreed with counsel for
the plaintiffs to adjourn defendants' time to answer or move with respect to the
complaint until August 1, 1995. This action was consolidated with the Securities
Actions as described above.

            Pursuant to an Order Directing Private Investigation Officers to
Take Testimony, entitled IN THE MATTER OF ICN PHARMACEUTICALS, INC., (P-177)
(the "Order"), a private investigation is being conducted by the SEC with
respect to

                                      C-1
<PAGE>   103
certain matters pertaining to the status and disposition of the Company's
Hepatitis C NDA. As set forth in the Order, the investigation concerns whether,
during the period June 1994, through February 1995, the Company, persons or
entities associated with it and others, in the offer and sale or in connection
with the purchase and sale of ICN common stock, engaged in possible violations
of Section 17(a) of the Securities Act of 1933 and Section 10(b) of the
Securities and Exchange Act of 1934 and Rule 10b-5 thereunder, by having
possibly (i) made false or misleading statements or omitted to state material
facts with respect to the status and disposition of the Hepatitis C NDA, or (ii)
purchased or sold ICN common stock while in possession of material, non-public
information concerning the status and disposition of the Hepatitis C NDA or
(iii) conveyed material, non-public information concerning the status and
disposition of the Hepatitis C NDA to other persons who may have purchased or
sold ICN stock. The Company is cooperating with the SEC in its investigation.

                                      C-2
<PAGE>   104
                                    EXHIBIT D

                                   [REDACTED]

                                      D-3
<PAGE>   105
                                    EXHIBIT E

                       ADVERSE EVENT REPORTING PROCEDURES

The Parties hereby agree that the following terms will govern disclosures of
each Party to the other with respect to adverse event reporting relating to the
Product as clinically tested or marketed by or on behalf of either Party.

         1.       An Adverse Event ("AE) is defined as:

                  (a) any experience which is adverse, including what are
commonly described as adverse or undesirable experiences, adverse events,
adverse reactions, side effects, or death due to any cause associated with or
observed in conjunction with the use of a drug, biological product, or devise in
humans, whether or not considered related to the use of that product:

                  -     occurring in the course of the use of the drug,
                        biological product or device,

                  -     associated with, or observed in conjunction with product
                        overdose, whether accidental or intentional,

                  -     associated with, or observed in conjunction with product
                        abuse, and/or

                  -     associated with, or observed in conjunction with product
                        withdrawal.

                  (b) Any significant failure of expected pharmacological or
biologic therapeutical action (with the exception of in clinical trials).

         2.       Serious or Non-Serious is defined as:

                  (a) A Serious AE is one that is life threatening or fatal,
permanently disabling, requires or prolongs in-patient hospitalization or
prolonged hospitalization, or is a congenital anomaly, cancer or overdose. In
addition, end organ toxicity, including hematological, renal, hepatic, and
central nervous system AE's, may be considered serious. In laboratory tests in
animals, a serious AE includes any experience suggesting significant risk for
human subjects.

                  (b) A Non-Serious AE is any AE which does not meet the
criteria for a serious AE.

                                       4
<PAGE>   106

         3.       Life-threatening is defined as: the patient is at immediate
risk of death from the AE as it occurs.

         4.       End-Organ Toxicity is defined as: A medically significant
event or lab value change in which a patient may not necessarily be
hospitalized or disabled, but is clinically significant enough to warrant
monitoring (e.g.  seizures, blood dyscrasias).

         5.       Expected or unexpected to defined as:

                  (a) Expected AE - An AE which is listed in the Investigator's
Brochure for clinical trials, included in local labelling (e.g., Summary of
Product Characteristics) for Marketed Drugs, or in countries with no local
labelling, in the Corporate Standard Prescribed Document.

                  (b) Unexpected AE - An AE that does not meet the criteria for
an expected AE or an AE which is listed but differs from that event in terms of
severity or specificity.

         6.       Associated with or related to the use of the drug is
defined as: A reasonable possibility exists that the AE was caused by the
drug.

         7.       Un-associated or unrelated to the use of the drug is
defined as: A reasonable possibility exists that the AE may not have been
caused by the drug.

         8.       NDA Holder is defined as: An "Applicant" as defined in 21 CFR
Part 314.3(b), for regulatory approval of a Product in any regulatory
jurisdiction, including a holder of a foreign equivalent thereto.

         9.       NDA Holder is defined as: A "Sponsor" as defined in 21 CFR
Part 312.3(b) of an investigational new drug in any regulatory jurisdiction,
including a holder of a foreign equivalent thereto.

         10.      Capitalized terms not defined in this Exhibit shall have the
meaning assigned thereto in the Exclusive License and Supply Agreement (the
"Agreement").

         11.      With respect to the Product, the Parties agree as follows:

                  All initial reports and any follow-up information (oral or
                  written) for any and all Serious AEs as defined above, (other
                  than with respect to animal studies) which become known to
                  either Party (other than from disclosure) by or on behalf of
                  the other Party must be communicated by telephone, telefax, or
                  electronically directly to the other Party and/or the NDA
                  Holder, IND Holder (individually and collectively referred to
                  as "Holders") within forty-eight hours of

                                       5
<PAGE>   107
                  receipt of the information. Written confirmation of the
                  Serious AE received by such Party should be sent to the other
                  Party and/or the Holders as soon as it becomes available, but
                  in any event within forty eight hours of initial report of the
                  Serious AE by such Party.

                  Both Parties shall exchange Medwatch and/or CIOMS forms and
                  other health authority reports within forty eight hours of
                  submission to any regulatory agency.

                  All initial reports and follow-up information received for all
                  Non-Serious AEs for marketed Product which become known to a
                  Party (other than from disclosure by or on behalf of the other
                  Party) must be communicated in writing, by telefax or
                  electronically to the other Party on a monthly basis.

                                       6
<PAGE>   108
                                    EXHIBIT F

                             PUBLICATION PROCEDURES

                                       1<PAGE>   1

                                                                   EXHIBIT 10.10

         **CERTAIN CONFIDENTIAL MATERIAL CONTAINED IN THIS DOCUMENT HAS BEEN
OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION
PURSUANT TO 17 C.F.R. SUBSECTION 200.80(B)(4), 200.83 AND 230.406.**

           AMENDMENT TO EXCLUSIVE LICENSE AND SUPPLY AGREEMENT BETWEEN
                            ICN PHARMACEUTICALS. INC.

                                       AND

                              SCHERING-PLOUGH LTD.
                               DATED JULY 28, 1995

                  This Amendment, effective as of the last date below, to the
Exclusive License and Supply Agreement between ICN Pharmaceuticals, Inc. ("ICN")
and Schering-Plough Ltd. ("Schering") dated July 28, 1995 (the "Agreement") is
entered into by and between the parties hereto with reference to the facts
below. Terms with initial capitals which are not specifically defined in this
Amendment shall have the defined meaning set forth in the Agreement.

                  WHEREAS, Section 3.2(c) of the Agreement provides for each
Party to file applications for Regulatory Approval and for Schering to provide
the required information necessary to allow ICN to file for Regulatory Approval
in the EU concurrently with Schering; and

                  WHEREAS, the parties wish to modify the Agreement to provide
for a more orderly process for Regulatory Approval in the EU; and

                  WHEREAS, the parties also wish to modify certain provisions of
the Agreement respecting the supply of product.

                  NOW, THEREFORE, in consideration of the foregoing premises and
the mutual covenants and obligations below, the Parties agree as follows:

                  1.       Section 1.2 of the Agreement shall be modified by
inserting a replacement sentence as the first sentence of that section:

                           "1.2     "Cost of Goods" means the cost to ICN or
                                    Schering, as the case may be, of Products
                                    [REDACTED] as applicable."
<PAGE>   2
                  2.       Section 3.2(c) of the Agreement shall be deleted in
its entirety and replaced with the following text:

                           "(c) In the EU, Schering shall be responsible for
                           filing applications for Regulatory Approval in the
                           name of each of the Parties. Schering shall be the
                           contact company for both applications, both at the
                           supra-national (e.g. EMEA) level and the local
                           country level. Schering shall have the responsibility
                           to manage the Regulatory Approval process for each of
                           the applications until all requisite approvals
                           necessary for successful commercialization, including
                           approval for pricing and third party reimbursement
                           approvals, are obtained. Neither Party shall
                           commercially enter the market until the other Party
                           has obtained substantially similar pricing and third
                           party (including applicable government) reimbursement
                           approvals, provided, however, that either Party shall
                           be permitted to enter the market if the other Party
                           chooses to delay market introduction for any other
                           reason."

                  3.       Section 6.4(b) of the Agreement shall be modified by
inserting the following text after the second sentence of that section:

                           "Prior to commercial launch in any country of the
                           Territory, the Estimated Selling Price for that
                           country shall be set at an amount equal to
                           [REDACTED]."

                  4.       Section 8.3(b) of the Agreement shall be modified by
inserting the following text after the first sentence of that section:

                           "However, unless otherwise specified in ICN's written
                           purchase requisition, Schering shall supply Product
                           to ICN in the form of capsules branded and blister
                           packed in cartons with ICN trade dress, labeled in
                           all EU languages and quality-control released in the
                           EU, such that Product so supplied will be suitable
                           for immediate sale to end users in the EU."

                  5.       This Amendment to the Agreement is incorporated
therein and expressly made a part thereof.

                  6.       This Amendment to the extent set forth herein,
amends, modifies and supplements the Agreement. Except as expressly modified
herein, all of the terms and provisions of the Agreement remain in full force
and effect and cannot be amended, modified or changed in any way whatsoever
except by a written instrument duly executed by the Parties hereto.

                                      -2-
<PAGE>   3
                  IN WITNESS WHEREOF, the Parties have executed this Amendment
effective as of the last date below.

SCHERING-PLOUGH LTD.                        ICN PHARMACEUTICALS, INC.

By:       /s/ David Poorvin                 By:       /s/ David C. Waft
          -------------------------                   --------------------------
          David Poorvin                               David C. Waft

Title:    Prokurist                         Title:    Executive Vice President
                                                      General Counsel &
                                                      Corporate Secretary

Date:     10 December 1997                  Date:     1/20/98
          -------------------------                   --------------------------

                                      -3-

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