Document:

Indenture, dated as of Nov 21,2006

 EXHIBIT 4.4 
 CHINA MEDICAL TECHNOLOGIES, INC. 
 3.50% CONVERTIBLE SENIOR SUBORDINATED NOTES
DUE 2011 
 INDENTURE 
 DATED AS OF NOVEMBER 21, 2006 
 WILMINGTON TRUST COMPANY 
 AS TRUSTEE 
 CITIBANK, N.A. 
 AS INITIAL AGENT 

 Table of Contents 
  

					
	 	    	 	  	Page
	ARTICLE 1 DEFINITIONS AND INCORPORATION BY REFERENCE	  	1
			
	 Section 1.01
	    	Definitions	  	1
	 Section 1.02
	    	Other Definitions	  	10
	 Section 1.03
	    	Trust Indenture Act Provisions	  	11
	 Section 1.04
	    	Rules of Construction	  	11
		
	ARTICLE 2 THE SECURITIES	  	12
			
	 Section 2.01
	    	Form and Dating	  	12
	 Section 2.02
	    	Execution and Authentication	  	13
	 Section 2.03
	    	Registrar, Transfer Agent, Paying Agent and Conversion Agent	  	14
	 Section 2.04
	    	Paying Agent to Hold Money in Trust	  	15
	 Section 2.05
	    	Lists of Holders of Securities	  	15
	 Section 2.06
	    	Transfer and Exchange	  	16
	 Section 2.07
	    	Replacement Securities	  	17
	 Section 2.08
	    	Outstanding Securities	  	17
	 Section 2.09
	    	Treasury Securities	  	18
	 Section 2.10
	    	Temporary Securities	  	18
	 Section 2.11
	    	Cancellation	  	18
	 Section 2.12
	    	Restricted Legend; Additional Transfer and Exchange Requirements	  	18
	 Section 2.13
	    	CUSIP Numbers	  	21
		
	ARTICLE 3 PURCHASE	  	21
			
	 Section 3.01
	    	Purchase of Securities at Option of the Holder upon a Fundamental Change	  	21
	 Section 3.02
	    	Effect of Fundamental Change Purchase Notice	  	24
	 Section 3.03
	    	Deposit of Fundamental Change Purchase Price	  	24
	 Section 3.04
	    	Repayment to the Company	  	25
	 Section 3.05
	    	Securities Purchased in Part	  	25
	 Section 3.06
	    	Compliance with Securities Laws upon Purchase of Securities	  	25
	 Section 3.07
	    	Purchase of Securities in Open Market	  	25
		
	ARTICLE 4 CONVERSION	  	26
			
	 Section 4.01
	    	Conversion Privilege and Conversion Rate	  	26
	 Section 4.02
	    	Conversion Procedure	  	28
	 Section 4.03
	    	Fractional Shares	  	30
	 Section 4.04
	    	Taxes on Conversion; Additional Amounts	  	30
	 Section 4.05
	    	Company to Provide Shares	  	31
	 Section 4.06
	    	Adjustment of Conversion Rate	  	32

  

 i 

					
	 Section 4.07
	    	No Adjustment.	  	40
	 Section 4.08
	    	Notice of Adjustment	  	40
	 Section 4.09
	    	Notice of Certain Transactions	  	41
	 Section 4.10
	    	Effect of Recapitalization, Reclassification, Consolidation, Merger or Sale	  	41
	 Section 4.11
	    	Trustee’s Disclaimer; Agents’ Disclamer	  	42
	 Section 4.12
	    	Voluntary Increase	  	42
	 Section 4.13
	    	Settlement in Cash, or a Combination of Cash and ADSs in Lieu of ADSs.	  	43
		
	ARTICLE 5 SUBORDINATION	  	44
			
	 Section 5.01
	    	Agreement of Subordination	  	44
	 Section 5.02
	    	Payments to Holders	  	44
	 Section 5.03
	    	Subrogation of Securities	  	47
	 Section 5.04
	    	Authorization to Effect Subordination	  	48
	 Section 5.05
	    	Notice to Trustee	  	48
	 Section 5.06
	    	Trustee’s Relation to Senior Indebtedness	  	49
	 Section 5.07
	    	No Impairment of Subordination	  	49
	 Section 5.08
	    	Certain Conversions Deemed Payment	  	49
	 Section 5.09
	    	Article Applicable to Paying Agents	  	50
	 Section 5.10
	    	Senior Indebtedness Entitled to Rely	  	50
		
	ARTICLE 6 COVENANTS	  	50
			
	 Section 6.01
	    	Payment of Securities	  	50
	 Section 6.02
	    	SEC and Other Reports	  	51
	 Section 6.03
	    	Compliance Certificates	  	51
	 Section 6.04
	    	Further Instruments and Acts	  	51
	 Section 6.05
	    	Maintenance of Corporate Existence	  	52
	 Section 6.06
	    	Rule 144A Information Requirement	  	52
	 Section 6.07
	    	Stay, Extension and Usury Laws	  	52
	 Section 6.08
	    	Payment of Additional Interest	  	52
	 Section 6.09
	    	Maintenance of Office or Agency	  	52
		
	ARTICLE 7 CONSOLIDATION; MERGER; CONVEYANCE; TRANSFER OR LEASE	  	53
			
	 Section 7.01
	    	Company May Consolidate, etc. only on Certain Terms	  	53
	 Section 7.02
	    	Successor Substituted	  	54
		
	ARTICLE 8 DEFAULT AND REMEDIES	  	54
			
	 Section 8.01
	    	Events of Default	  	54
	 Section 8.02
	    	Acceleration	  	56
	 Section 8.03
	    	Other Remedies	  	56
	 Section 8.04
	    	Waiver of Defaults and Events of Default	  	57
	 Section 8.05
	    	Control by Majority	  	57
	 Section 8.06
	    	Limitations on Suits	  	57

  

 ii 

					
	 Section 8.07
	    	Rights of Holders to Receive Payment and to Convert	  	58
	 Section 8.08
	    	Collection Suit by Trustee	  	58
	 Section 8.09
	    	Trustee may File Proofs of Claim	  	58
	 Section 8.10
	    	Priorities	  	59
	 Section 8.11
	    	Undertaking for Costs	  	59
		
	ARTICLE 9 TRUSTEE AND AGENTS	  	59
			
	 Section 9.01
	    	Obligations of Trustee and Agents	  	59
	 Section 9.02
	    	Rights of Trustee and Agents	  	61
	 Section 9.03
	    	Individual Rights of Trustee and Agents	  	62
	 Section 9.04
	    	Trustee’s and Agents’ Disclaimer	  	62
	 Section 9.05
	    	Notice of Default or Events of Default	  	62
	 Section 9.06
	    	Reports by Trustee to Holders	  	63
	 Section 9.07
	    	Compensation and Indemnity	  	63
	 Section 9.08
	    	Replacement of Trustee or Agents	  	64
	 Section 9.09
	    	Successor Trustee or Agent by Merger, etc	  	65
	 Section 9.10
	    	Eligibility; Disqualification	  	65
	 Section 9.11
	    	Preferential Collection of Claims against Company	  	65
		
	ARTICLE 10 SATISFACTION AND DISCHARGE OF INDENTURE	  	66
			
	 Section 10.01
	    	Satisfaction and Discharge of Indenture	  	66
	 Section 10.02
	    	Application of Trust Money	  	67
	 Section 10.03
	    	Repayment to Company	  	67
	 Section 10.04
	    	Reinstatement	  	67
		
	ARTICLE 11 AMENDMENTS; SUPPLEMENTS AND WAIVERS	  	67
			
	 Section 11.01
	    	Without Consent of Holders	  	67
	 Section 11.02
	    	With Consent of Holders	  	68
	 Section 11.03
	    	Compliance with Trust Indenture Act	  	69
	 Section 11.04
	    	Revocation and Effect of Consents	  	69
	 Section 11.05
	    	Notation on or Exchange of Securities	  	70
	 Section 11.06
	    	Trustee to Sign Amendments, etc	  	70
	 Section 11.07
	    	Effect of Supplemental Indentures	  	70
		
	ARTICLE 12 MISCELLANEOUS	  	70
			
	 Section 12.01
	    	Trust Indenture Act Controls	  	70
	 Section 12.02
	    	Notices	  	70
	 Section 12.03
	    	Communications by Holders with other Holders	  	72
	 Section 12.04
	    	Certificate and Opinion as to Conditions Precedent	  	72
	 Section 12.05
	    	Record Date for Vote or Consent of Holders of Securities	  	72
	 Section 12.06
	    	Rules by Trustee, Paying Agent, Registrar and Conversion Agent	  	73
	 Section 12.07
	    	Legal Holidays	  	73
	 Section 12.08
	    	Governing Law	  	73

  

 iii 

					
	 Section 12.09
	    	Submission to Jurisdiction	  	73
	 Section 12.10
	    	Judgment Currency	  	74
	 Section 12.11
	    	No Adverse Interpretation of other Agreements	  	74
	 Section 12.12
	    	No Recourse against Others	  	74
	 Section 12.13
	    	No Security Interest Created	  	74
	 Section 12.14
	    	Successors	  	74
	 Section 12.15
	    	Multiple Counterparts	  	74
	 Section 12.16
	    	Separability	  	74
	 Section 12.17
	    	Table of Contents, Headings, etc	  	74

  

 iv 

 CROSS REFERENCE TABLE* 
  

			
	 TIA Section
	  	Indenture Section
	 Section 310
	  	12.01
	             310(a)(1)
	  	9.10
	                   (a)(2)
	  	9.10
	                   (a)(3)
	  	N.A.**
	                   (a)(4)
	  	N.A.
	                   (a)(5)
	  	9.10
	                   (b)
	  	9.10
	                   (c)
	  	N.A.
	 Section 311
	  	12.01
	             311(a)
	  	9.11
	                   (b)
	  	9.11
	                   (c)
	  	N.A.
	 Section 312
	  	12.01
	             312(a)
	  	N.A
	                   (b)
	  	12.03
	                   (c)
	  	12.03
	 Section 313
	  	12.01
	             313(a)
	  	9.06(a)
	                   (b)(1)
	  	N.A.
	                   (b)(2)
	  	9.06(a)
	                   (c)
	  	9.06(a)
	 Section 314
	  	12.01
	             314(a)
	  	6.02(a)
	                   (b)
	  	N.A.
	                   (c)(1)
	  	N.A.
	                   (c)(2)
	  	N.A.
	                   (c)(3)
	  	N.A.
	                   (d)
	  	N.A.
	                   (e)
	  	N.A.
	                   (f)
	  	N.A.
	 Section 315
	  	12.01
	             315(a)
	  	9.01(b)
	                   (b)
	  	9.05
	                   (d)(1)
	  	9.01(d)
	                   (d)(2)
	  	9.01(d)
	                   (d)(3)
	  	9.01(d)
	                   (e)
	  	8.11
	 Section 316
	  	12.01
	             316(a)
	  	N.A.
	                   (b)
	  	N.A.
	                   (c)
	  	N.A.
	 Section 317
	  	12.01
	 Section 318(c)
	  	12.01

	*	This Cross-Reference Table shall not, for any purpose, be deemed a part of this Indenture. 

	**	N.A. means Not Applicable. 

  

 v 

 THIS INDENTURE dated as of November 21, 2006 is between China Medical Technologies, Inc., a company
organized under the laws of the Cayman Islands (the “Company”), Wilmington Trust Company, a Delaware banking corporation (the “Trustee”) and Citibank, N.A., a national banking association (the “Initial Agent”).

 In consideration of the purchase of the Securities (as defined herein) by the Holders thereof, both parties agree as follows for the
benefit of the other and for the equal and ratable benefit of the Holders of the Company’s 3.50% Convertible Senior Subordinated Notes Due November 15, 2011. 
 ARTICLE 1 
 DEFINITIONS AND INCORPORATION BY REFERENCE 
 Section 1.01 Definitions. 
 “Additional Interest” means the additional interest that will accrue at a rate per annum of one-quarter of one percent (0.25%) of the principal amount of the Securities then outstanding for the first 90-day period from the day
following the occurrence of any of the following: (a) a Shelf Registration Statement (as defined in the Registration Rights Agreement) is not filed with the SEC on or before the 120th calendar day following November 21, 2006, (b) a Shelf Registration Statement is not declared effective on or prior to the 210th calendar day following November 21, 2006, (c) after effectiveness, the Shelf Registration Statement ceases to be
effective or fails to be usable by the Holders without being succeeded within seven Business Days by a post-effective amendment or a report filed with the SEC pursuant to the Securities Exchange Act of 1934, as amended, that cures the failure to be
effective or usable, or (d) the prospectus that makes up part of the Shelf Registration Statement is unusable by the Holders for any reason, and the number of days for which the Shelf Registration Statement shall not be usable exceeds the
suspension period permitted under Section 2.5 of the Registration Rights Agreement. Additional Interest will accrue thereafter at a rate per annum of one-half of one percent (0.50%) of the principal amount of the Securities then outstanding;
provided that in no event shall Additional Interest accrue at a rate per annum exceeding one half of one percent (0.50%) of the principal amount of the Securities then outstanding; provided further that no Additional Interest shall
accrue after November 21, 2008. All references herein to interest accrued or payable as of any date shall include any Additional Interest accrued or payable as of such date as provided in the Registration Rights Agreement. 
 “ADSs” means the Company’s American Depositary Shares, each of which represents 10 Ordinary Shares (or the right to receive 10 Ordinary
Shares). 
 “ADS Price” means the price paid, or deemed to be paid, per Ordinary Share in connection with a Fundamental Change,
multiplied by the number of Ordinary Shares then represented by each ADS, as determined pursuant to Section 4.01(e). 
 “Affiliate” means, with respect to any specified person, any other person directly or indirectly controlling or controlled by or under direct or indirect common control with such specified person. For the purposes of this
definition, “control” when used with respect to any 

 person means the power to direct the management and policies of such person, directly or indirectly, whether through the
ownership of voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 
 “Agent” means any Registrar, Transfer Agent, Authenticating Agent, Paying Agent or Conversion Agent. 
 “Applicable Procedures” means, with respect to any transfer or exchange of beneficial ownership interests in a Global Security, the rules and procedures of the Depositary, to the extent applicable to such transfer or exchange.

 “Beneficial Ownership” means the definition such term is given in accordance with Rule 13d-3 promulgated by the SEC under the
Exchange Act. 
 “Board of Directors” means either the board of directors of the Company or any committee of the Board of Directors
authorized to act for it with respect to this Indenture. 
 “Business Day” means any weekday that is not a day on which banking
institutions in The City of New York are authorized or obligated to close. 
 “Capital Stock” of any Person means any and all
shares, interests, rights to purchase, warrants, options, participations or other equivalents of or interests in (however designated) equity of such Person, but excluding any debt securities convertible into such equity. 
 “Cash” or “cash” means such coin or currency of the United States as at any time of payment is legal tender for the payment of public
and private debts. 
 “Cash Settlement Averaging Period” means, in respect of a Conversion Date, the 20 consecutive Trading Day
period beginning on the Trading Day following the Retraction Date. 
 “Certificated Security” means a Security that is in
substantially the form attached as Exhibit A but that does not include the legend or the schedule called for by footnote 1 thereof. 
 “Change of Control” means the occurrence of any of the following after the date hereof: (i) the acquisition by any Person of Beneficial Ownership, directly or indirectly, through a purchase, merger or other acquisition
transaction or series of transactions, of shares of the Company’ Capital Stock entitling that Person to exercise 50% or more of the total voting power of all shares of the Company’s Capital Stock entitled to vote generally in elections of
directors, other than any acquisition by the Company, any of its subsidiaries or any of its employee benefit plans; or (ii) the consolidation or merger of the Company with or into any other Person, any merger of another Person into the Company,
or any conveyance, transfer, sale, lease or other disposition of all or substantially all of the Company’s properties and assets to another Person other than to one or more of the Company’s wholly-owned subsidiaries, provided that
this clause (ii) shall not apply to (A) any transaction (x) that does not result in any reclassification, conversion, exchange or cancellation of outstanding shares of the Company’s Capital Stock and (y) pursuant to which
holders of the Company’s Capital Stock immediately prior to the transaction have the entitlement to exercise, directly or indirectly, 50% or more of the total voting power of all shares of the Capital Stock entitled to vote generally in
elections of directors 
  

 2 

 of the continuing or surviving Person immediately after the transaction; or (B) any merger solely for the purpose of
changing the Company’s jurisdiction of incorporation and resulting in a reclassification, conversion or exchange of outstanding Ordinary Shares solely into shares of common stock of the surviving entity. Notwithstanding anything to the contrary
set forth herein, it will not otherwise constitute a Change of Control if 100% of the consideration for the Company’s shares (excluding cash payments for fractional shares and cash payments made in respect of dissenters’ appraisal rights)
in the transaction or transactions constituting a Change of Control consists of securities which are traded on a U.S. national securities exchange or quoted on the Nasdaq Global Select Market, or which will be so traded or quoted when issued or
exchanged in connection with the Change of Control, and as a result of such transaction or transactions the Securities become convertible solely into such securities; provided that, with respect to an entity organized under the laws of a
jurisdiction outside the United States, such entity has a worldwide total market capitalization of its equity securities of at least three times the market capitalization of the Company before giving effect to the consolidation or merger.

 “Closing Sale Price” means on any Trading Day, the reported closing sale price per ADS (or if no closing sale price is reported,
the average of the closing bid and ask prices per ADS or, if more than one in either case, the average of the average closing bid and the average closing ask prices per ADS) on such date reported by the Nasdaq Global Select Market or, if the ADSs
are not listed on the Nasdaq Global Select Market, as reported by the principal other United States national or regional securities exchange on which the ADSs are traded, or if the ADSs are not listed on a United States national or regional
securities exchange, as reported by the principal other market on which the ADSs are then traded. In the absence of the foregoing, the Closing Sale Price per ADS shall be an amount as determined in good faith by the Board of Directors (which
determination shall be conclusive to be the fair value of such ADSs) and shall be evidenced by an Officers’ Certificate delivered to the Trustee. 
 “Company” means the party named as such in the first paragraph of this Indenture until a successor replaces it pursuant to the applicable provisions of this Indenture, and thereafter “Company”
shall mean such successor Company. 
 “Conversion Price” per ADS as of any day means the result obtained by dividing
(i) $1,000 by (ii) the then applicable Conversion Rate, rounded to the nearest cent. 
 “Conversion Rate” means the rate
at which ADSs shall be delivered upon conversion, which rate shall be initially 31.0318 ADSs for each $1,000 principal amount of Securities, as adjusted from time to time pursuant to the provisions of this Indenture. 
 “Conversion Value” means, per $1,000 principal amount of Securities, an amount equal to the sum of the Daily Conversion Value Amounts for each
of the Trading Days in the Cash Settlement Averaging Period. 
 “Corporate Trust Office” means the office of the Trustee at which
at any particular time the trust created by this Indenture shall be administered, which initially will be the office of Wilmington Trust Company located at Rodney Square North, 1100 N. Market Street, Wilmington, Delaware 19890-0001, Attention:
Corporate Capital Market Services. 
  

 3 

 “Daily ADS Amount” means, for each Trading Day of the Cash Settlement Averaging Period and for
each $1,000 principal amount of Securities, the number of ADSs (but in no event less than zero) equal to (i) the amount of (a) the Closing Sale Price on such Trading Day multiplied by the Conversion Rate in effect on the Conversion Date,
less (b) $1,000; divided by (ii) the Closing Sale Price on such Trading Day multiplied by 20. 
 “Daily Conversion Value
Amount” means, for each Trading Day of the Cash Settlement Averaging Period and for each $1,000 principal amount of Securities, the amount equal to (i) the Closing Sale Price on such Trading Day multiplied by the Conversion Rate in effect
on such Trading Day; divided by (ii) 20. 
 “Default” means, when used with respect to the Securities, any event that is or,
after notice or passage of time, or both, would be, an Event of Default. 
 “Deposit Agreement” means the Deposit Agreement, dated
as of August 9, 2005, by and among the Citibank, N.A., as ADS depositary, the Company, and the holders and beneficial owners of ADSs issued thereunder, as supplemented by the Letter Agreement. 
 “Designated Senior Indebtedness” means the Company’s obligations under any particular Senior Indebtedness in which the instrument creating
or evidencing the same or the assumption or guarantee thereof (or related agreements or documents to which the Company is a party) expressly provides that such Indebtedness shall be “Designated Senior Indebtedness” for purposes of this
Indenture (provided that such instrument, agreement or other document may place limitations and conditions on the right of such Senior Indebtedness to exercise the rights of Designated Senior Indebtedness). If any payment made to any holder of any
Designated Senior Indebtedness or its representative with respect to such Designated Senior Indebtedness is rescinded or must otherwise be returned by such holder or representative of such holder upon the insolvency, bankruptcy or reorganization of
the Company or otherwise, the reinstated Indebtedness of the Company arising as a result of such rescission or return shall constitute Designated Senior Indebtedness effective as of the date of such rescission or return. 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, as in effect from
time to time. 
 “Final Maturity Date” means November 15, 2011. 
 “Fundamental Change” means the occurrence of a Change of Control or a Termination of Trading following the original issuance of the Securities.

 “Fundamental Change Effective Date” means the date on which any Fundamental Change becomes effective. 
 “Fundamental Change Purchase Price” of any Security, means 100% of the principal amount of the Security to be repurchased plus accrued and
unpaid interest, if any, and Additional Interest, if any, to, but excluding, the Fundamental Change Repurchase Date. 
 “GAAP”
means generally accepted accounting principles in the United States of America as in effect from time to time, including those set forth in (1) the opinions and pronouncements 
  

 4 

 of the Accounting Principles Board of the American Institute of Certified Public Accountants, (2) the statements and
pronouncements of the Public Company Accounting Oversight Board and the Financial Accounting Standards Board, (3) such other statements by such other entity as approved by a significant segment of the accounting profession and (4) the
rules and regulations of the SEC governing the inclusion of financial statements (including pro forma financial statements) in registration statements filed under the Securities Act and periodic reports required to be filed pursuant to
Section 13 of the Exchange Act, including opinions and pronouncements in staff accounting bulletins and similar written statements from the accounting staff of the SEC. 
 “Global Security” means a Security in global form that is in substantially the form attached as Exhibit A and that includes the legend
and schedule called for in footnote 1 thereof and which is deposited with the Depositary or its custodian and registered in the name of the Depositary or its nominee. 
 “Holder” or “Holder of a Security” means the person in whose name a Security is registered on the Registrar’s books. 
 “Indebtedness” means, with respect to any Person, without duplication: 
  

	 	(1)	all indebtedness, obligations and other liabilities (contingent or otherwise) for borrowed money (including obligations in respect of overdrafts, foreign exchange contracts,
currency exchange agreements, interest rate protection agreements, and any loans or advances from banks, whether or not evidenced by notes or similar instruments) or evidenced by credit or loan agreements, bonds, debentures, notes or similar
instruments (whether or not the recourse of the lender is to the whole of our assets or to only a portion thereof) (other than any trade accounts payable or other accrued current expense or liabilities incurred in the ordinary course of business in
connection with the obtaining of materials or services); 

  

	 	(2)	all reimbursement obligations and other liabilities (contingent or otherwise) with respect to letters of credit, bank guarantees, bankers’ acceptances;

  

	 	(3)	all obligations and liabilities (contingent or otherwise) 

  

	 	(A)	in respect of leases required, in conformity with GAAP, to be accounted for as capitalized lease obligations on its balance sheet, 

  

	 	(B)	as lessee under other leases for facilities equipment (and related assets leased together therewith), whether or not capitalized, entered into or leased for financing purposes (as
determined by such Person), or 

  

 5 

	 	(C)	under any lease or related document (including a purchase agreement) in connection with the lease of real property or improvements (or any personal property included as part of any
such lease) which provides that such Person is contractually obligated to purchase or cause a third party to purchase the leased property and thereby guarantee a minimum residual value of the leased property to the lessor and all obligations under
such lease or related document to purchase or to cause a third party to purchase such leased property (whether or not such lease transaction is characterized as an operating lease or a capitalized lease in accordance with GAAP, including without
limitation, synthetic leases); 

  

	 	(4)	all obligations (contingent or otherwise) with respect to an interest rate, currency or other swap, cap, floor or collar agreement, hedge agreement, forward contract, or other
similar instrument or foreign currency hedge, exchange, purchase or similar instrument or agreement; 

  

	 	(5)	all direct or indirect guarantees, agreements to be jointly liable or similar agreements in respect of, and obligations or liabilities (contingent or otherwise) to purchase or
otherwise acquire or otherwise assure a creditor against loss in respect of, indebtedness, obligations or liabilities of another person of the kind described in clauses (1) through (4); 

  

	 	(6)	any indebtedness or other obligations described in clauses (1) through (5) secured by any mortgage, pledge, lien or other encumbrance existing on property which is owned
or held by such Person, regardless of whether the indebtedness or other obligation secured thereby shall be assumed by such Person; and 

  

	 	(7)	any and all deferrals, renewals, extensions, refinancings and refundings of, or amendments, modifications or supplements to, any indebtedness, obligation or liability of the kind
described in clauses (1) through (6). 

 “Indenture” means this Indenture as amended or supplemented from time
to time pursuant to the terms of this Indenture, including the provisions of the TIA that are automatically deemed to be a part of this Indenture by operation of the TIA. 
 “Initial Agent” means Citibank, N.A., a national banking association. 
 “Initial
Purchaser” means Merrill Lynch & Co., Merrill Lynch, Pierce, Fenner & Smith Incorporated. 
  

 6 

 “Interest Payment Date” means May 15 and November 15 of each year, commencing
May 15, 2007. 
 “Issue Date” of any Security means the date on which the Security was originally issued or deemed issued as
set forth on the face of the Security. 
 “Letter Agreement” means the Letter Agreement dated as of November 21, 2006 by and
between the Company and Citibank, N.A., as ADS depositary. 
 “Master Restricted ADR” means the American Depositary Receipt issued
pursuant to the terms of the Deposit Agreement to represent any Restricted ADSs issuable upon any conversion of the Securities. 
 “Officer” means the Chairman or any Co-Chairman of the Board, any Vice Chairman of the Board, the Chief Executive Officer, the President, any Vice President, the Chief Financial Officer, the Controller, the Secretary, any
Assistant Controller or any Assistant Secretary of the Company. 
 “Officers’ Certificate” means a certificate signed on
behalf of the Company by two Officers; provided, however, that for purposes of Sections 4.11 and 6.03, “Officers’ Certificate” means a certificate signed by (a) the principal executive officer, principal financial officer
or principal accounting officer of the Company and (b) one other officer. 
 “Opinion of Counsel” means a written opinion from
legal counsel reasonably acceptable to the Trustee. The counsel may be an employee of or counsel to the Company. 
 “Ordinary
Shares” means the ordinary shares, par value US$0.10 per share, of the Company, as such shares exist on the date of this Indenture and any shares of any class or classes of Capital Stock of the Company resulting from any reclassification or
reclassifications thereof, or, in the event of a merger, consolidation or other similar transaction involving the Company that is otherwise permitted hereunder in which the Company is not the surviving corporation, the common stock, common equity
interests, ordinary shares or depositary shares or other certificates representing common equity interests of such surviving corporation or its direct or indirect parent corporation, and which have no preference in respect of dividends or of amounts
payable in the event of any voluntary or involuntary liquidation, dissolution or winding up of the Company and which are not subject to redemption by the Company; provided, however, that if at any time there shall be more than one such resulting
class, the shares of each such class then so issuable on conversion of Securities shall be substantially in the proportion which the total number of shares of such class resulting from all such reclassifications bears to the total number of shares
of all such classes resulting from all such reclassifications. 
 “Person” or “person” means any individual, corporation,
partnership, limited liability company, joint venture, association, joint-stock company, trust, unincorporated organization, government or any agency or political subdivision thereof or any syndicate or group that would be deemed to be a
“person” under Section 13(d)(3) of the Exchange Act or any other entity. 
 “Principal” or “principal” of
a debt security, including the Securities, means the principal of the security plus, when appropriate, the premium, if any, on the security. 
  

 7 

 “Registration Rights Agreement” means the Registration Rights Agreement, dated as of
November 21, 2006, between the Company and the Initial Purchaser, as amended from time to time in accordance with its terms. 
 “Regular Record Date” means, with respect to each Interest Payment Date, the May 1 or November 1, as the case may be, immediately preceding such Interest Payment Date. 
 “Resale Restriction Termination Date” means the date that is two (2) years after the final issuance of Securities under the Purchase
Agreement. 
 “Responsible Officer” means, when used with respect to the Trustee, any officer within the corporate trust services
department of the Trustee with direct responsibility for the administration of this Indenture and also means, with respect to a particular corporate trust matter, any other officer to whom such matter is referred because of such person’s
knowledge of and familiarity with the particular subject. 
 “Restricted ADSs” means that series of ADSs that are subject to
certain restrictions pursuant to and are issued in accordance with the terms and conditions of the Deposit Agreement. 
 “Restricted
Global Security” means a Global Security that is a Restricted Security. 
 “Restricted Security” means a Security required to
bear the restricted legend called for in footnote 2 thereof and in the form of Security annexed as Exhibit A. 
 “Rule 144” means
Rule 144 under the Securities Act or any successor to such Rule. 
 “Rule 144A” means Rule 144A under the Securities Act or any
successor to such Rule. 
 “SEC” means the Securities and Exchange Commission. 
 “Securities” means the up to $150,000,000 aggregate principal amount of 3.50% Convertible Senior Subordinated Notes due 2011, or any of them
(each a “Security”), as amended or supplemented from time to time, that are issued under this Indenture. 
 “Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder, as in effect from time to time. 
 “Securities Custodian” means the Registrar, as custodian with respect to the Securities in global form, or any successor thereto. 
 “Senior Indebtedness” means the principal of, premium, if any, interest (including all interest accruing subsequent to the commencement of any bankruptcy or similar proceeding, whether or not a claim for
post-petition interest is allowable as a claim in any such proceeding) and rent payable on or in connection with, and all fees, costs, expenses and other amounts accrued or due on or in connection with, Indebtedness of the Company, whether secured
or unsecured, absolute or contingent, due or to become due, outstanding on the date of this Indenture or thereafter created, incurred, assumed, guaranteed or in effect guaranteed by the 
  

 8 

 Company, including all deferrals, renewals, extensions or refundings of, or amendments, modifications or
supplements to, the foregoing, unless in the case of any particular Indebtedness the instrument creating or evidencing the same or the assumption or guarantee thereof expressly provides that such Indebtedness shall not be senior in right of payment
to the Securities or expressly provides that such Indebtedness is on the same basis or junior to the Securities. Senior Indebtedness does not include: 
  

	 	(1)	Indebtedness that expressly provides that such Indebtedness shall not be senior in right of payment to the Securities or expressly provides that such Indebtedness is on the same
basis or junior to the Securities; 

  

	 	(2)	any Indebtedness of the Company to any of its subsidiaries; 

  

	 	(3)	Indebtedness evidenced by the Securities; and 

  

	 	(4)	any obligation for federal, state, local or other taxes. 

 “Senior Subordinated Indebtedness” means, with respect to the Company, the Securities and any other Indebtedness of the Company that specifically provides that such Indebtedness is to have the same rank as the Securities in right
of payment and is not subordinated by its terms in right of payment to any Indebtedness of the Company that is not Senior Indebtedness. 
 “Subsidiary” means, in respect of any Person, any corporation, association, partnership or other business entity of which more than 50% of the total voting power of shares of Capital Stock entitled (without regard to the
occurrence of any contingency within the control of such Person to satisfy) to vote in the election of directors, managers, general partners or trustees thereof is at the time owned or controlled, directly or indirectly, by (i) such Person;
(ii) such Person and one or more Subsidiaries of such Person; or (iii) one or more Subsidiaries of such Person. 
 “Termination of Trading” means the termination (but not the temporary suspension) of trading of the ADSs, which will be deemed to have occurred if the ADSs are neither listed for trading on a United States national securities
exchange nor approved for listing on the Nasdaq Global Select Market or any United States system of automated dissemination of quotations of securities prices, or traded in over-the-counter securities markets, and the Company’s Ordinary Shares
are not so listed or approved for listing in the United States. 
 “TIA” means the Trust Indenture Act of 1939, as amended, and the
rules and regulations thereunder as in effect on the date of this Indenture, except to the extent that the Trust Indenture Act or any amendment thereto expressly provides for application of the Trust Indenture Act as in effect on another date.

 “Trading Day” means any day on which the Nasdaq Global Select Market or, if the ADSs are not listed on the Nasdaq Global Select
Market, the other principal United States national or regional securities exchange on which the ADSs are listed, is open for trading or, if the ADSs are not so listed, admitted for trading or quoted, any Business Day. A Trading Day only includes
those days that have a scheduled closing time of 4:00 p.m. (New York City time) or the then standard closing time for regular trading on the relevant exchange or trading system. 
  

 9 

 “Trustee” means the party named as such in the first paragraph of this Indenture until a
successor replaces it in accordance with the provisions of this Indenture, and thereafter means the successor. 
 “Trust Officer”
means, with respect to the Trustee, any officer assigned to the Corporate Trust Office, and also, with respect to a particular matter, any other officer to whom such matter is referred because of such officer’s knowledge of and familiarity with
the particular subject. 
 “Vice President” when used with respect to the Company, means any vice president, whether or not
designated by a number or a word or words added before or after the title “vice president.” 
 Section 1.02 Other
Definitions. 
  

			
	 Term
	  	Defined in Section
	 “Additional Amounts”
	  	4.04
	 “Agent Members”
	  	2.01
	 “Authenticating Agent”
	  	2.02
	 “Bankruptcy Law”
	  	8.01
	 “Business Combination”
	  	4.10
	 “Company Order”
	  	2.02
	 “Conversion Agent”
	  	2.03
	 “Conversion Date”
	  	4.02
	 “Conversion Retraction Period”
	  	4.13
	 “DTC”
	  	2.01
	 “DTC Legend”
	  	2.01
	 “Depositary”
	  	2.01
	 “Determination Date”
	  	4.06
	 “Distributed Securities”
	  	4.06
	 “Event of Default”
	  	8.01
	 “Expiration Date”
	  	4.06
	 “Expiration Time”
	  	4.06
	 “Fundamental Change Company Notice”
	  	3.01
	 “Fundamental Change Purchase Date”
	  	3.01
	 “Fundamental Change Purchase Notice”
	  	3.01
	 “Legal Holiday”
	  	12.07
	 “Make Whole Premium”
	  	4.01
	 “Notice of Default”
	  	8.01
	 “Paying Agent”
	  	2.03
	 “Payment Blockage Notice”
	  	5.02
	 “Primary Registrar”
	  	2.03
	 “Purchase Agreement”
	  	2.01
	 “Purchased Shares”
	  	4.06
	 “QIB”
	  	2.01
	 “Receiver”
	  	8.01
	 “record date”
	  	4.06
	 “Registrar”
	  	2.03
	 “Relevant Jurisdiction”
	  	4.04
	 “Restricted Legend”
	  	2.12
	 “Retraction Date”
	  	4.13

  

 10 

			
	 Term
	  	Defined in Section
	 “Rights”
	  	4.06
	 “Rights Plan”
	  	4.06
	 “Spinoff Securities”
	  	4.06
	 “Spinoff Valuation Period”
	  	4.06
	 “tender offer”
	  	4.06
	 “Transfer Agent”
	  	2.03
	 “Triggering Distribution”
	  	4.06

 Section 1.03 Trust Indenture Act Provisions. 
 Whenever this Indenture refers to a provision of the TIA, that provision is incorporated by reference in and made a part of this Indenture. This Indenture
shall also include those provisions of the TIA required to be included herein by the provisions of the Trust Indenture Reform Act of 1990. The following TIA terms used in this Indenture have the following meanings: 
 “indenture securities” means the Securities; 
 “indenture security holder” means a Holder of a Security; 
 “indenture to be qualified”
means this Indenture; 
 “indenture trustee” or “institutional trustee” means the Trustee; and “obligor” on the
indenture securities means the Company or any other obligor on the Securities. 
 All other terms used in this Indenture that are defined in
the TIA, defined by TIA reference to another statute or defined by any SEC rule and not otherwise defined herein have the meanings assigned to them therein. 
 Section 1.04 Rules of Construction. 
 (a) Unless the context otherwise requires:

 (1) a term has the meaning assigned to it; 
 (2) an accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP; 
 (3) words in the singular include the plural, and words in the plural include the singular; provisions apply to successive events and
transactions; 
 (4) the term “merger” includes a statutory share exchange and the term “merged” has a
correlative meaning; 
 (5) the masculine gender includes the feminine and the neuter; 
 (6) references to agreements and other instruments include subsequent amendments thereto; and 
  

 11 

 (7) all “Article”, “Exhibit” and “Section” references are
to Articles, Exhibits and Sections, respectively, of or to this Indenture unless otherwise specified herein, and the terms “herein,” “hereof” and other words of similar import refer to this Indenture as a whole and not to any
particular Article, Section or other subdivision. 
 ARTICLE 2 
 THE SECURITIES 
 Section 2.01 Form and Dating. The Securities and
the Authenticating Agent’s certificate of authentication shall be substantially in the respective forms set forth in Exhibit A, which Exhibit is incorporated in and made part of this Indenture. The Securities may have notations, legends
or endorsements required by law, stock exchange or automated quotation system rule or regulation or usage. The Company shall provide any such notations, legends or endorsements to the Trustee and the Authenticating Agent in writing. Each Security
shall be dated the date of its authentication. The Securities are being offered and sold by the Company pursuant to a Purchase Agreement dated November 15, 2006 (the “Purchase Agreement”) among the Company and the Initial Purchaser,
in transactions exempt from, or not subject to, the registration requirements of the Securities Act. 
 (a) Restricted Global
Securities. All of the Securities are initially being offered and sold to qualified institutional buyers as defined in Rule 144A (collectively, “QIBS” or individually, each a “QIB”) in reliance on Rule 144A under the
Securities Act and shall be issued initially in the form of one or more Restricted Global Securities, which shall be deposited on behalf of the purchasers of the securities represented thereby with the Securities Custodian, as custodian for the
depositary, The Depository Trust Company (“DTC”, and such depositary, or any successor thereto, being hereinafter referred to as the “Depositary”), and registered in the name of its nominee, Cede & Co. (or any successor
thereto), for the accounts of participants in the Depositary, duly executed by the Company and authenticated by the Authenticating Agent as hereinafter provided. Subject to Section 2.02 hereof, the aggregate principal amount of the Restricted
Global Securities may from time to time be increased or decreased by adjustments made on the records of the Securities Custodian as hereinafter provided, subject in each case to compliance with the Applicable Procedures. 
 (b) Global Securities in General. Each Global Security shall represent such of the outstanding Securities as shall be specified therein and each
shall provide that it shall represent the aggregate amount of outstanding Securities from time to time endorsed thereon and that the aggregate amount of outstanding Securities represented thereby may from time to time be reduced or increased, as
appropriate, to reflect replacements, exchanges, purchases or conversions of such Securities. Any adjustment of the aggregate principal amount of a Global Security to reflect the amount of any increase or decrease in the amount of outstanding
Securities represented thereby shall be made on the records of the Securities Custodian, as custodian for the Depositary. 
 Members of, or
participants in, the Depositary (“Agent Members”) shall have no rights under this Indenture with respect to any Global Security held on their behalf by the Depositary or under the Global Security, and the Depositary (including, for this
purpose, its nominee) may be 
  

 12 

 treated by the Company, the Trustee, any Agent and any other agent of the Company, the Trustee or the Agents as the
absolute owner and Holder of such Global Security for all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall (1) prevent the Company, the Trustee, any Agent or any agent of the Company, the Trustee or the Agents from
giving effect to any written certification, proxy or other authorization furnished by the Depositary or (2) impair, as between the Depositary and its Agent Members, the operation of customary practices governing the exercise of the rights of a
Holder of any Security. 
 (c) Book Entry Provisions. The Company shall execute and the Authenticating Agent shall, in accordance with
this Section 2.01(c), authenticate and deliver initially one or more Global Securities that (1) shall be registered in the name of the Depositary or its nominee, (2) shall be delivered by the Authenticating Agent to the Depositary or
pursuant to the Depositary’s instructions and (3) shall bear legends (the “DTC Legend”) substantially to the following effect: 
 “UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME
OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY
OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND, UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A
NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.” 
 Section 2.02 Execution and Authentication. 
 (a) The aggregate principal amount of Securities which may be authenticated and delivered under this Indenture is limited to $150,000,000 aggregate principal amount, except as provided in Sections 2.06 and 2.07.

 (b) An Officer shall sign the Securities for the Company by manual or facsimile signature. Typographic and other minor errors or defects
in any such facsimile signature shall not affect the validity or enforceability of any Security that has been authenticated and delivered by the Authenticating Agent. 
  

 13 

 (c) If an Officer whose signature is on a Security no longer holds that office at the time the
Authenticating Agent authenticates the Security, the Security shall be valid nevertheless. 
 (d) A Security shall not be valid until an
authorized signatory of the Authenticating Agent by manual or facsimile signature signs the certificate of authentication on the Security. The signature shall be conclusive evidence that the Security has been authenticated under this Indenture.

 (e) The Authenticating Agent shall authenticate and make available for delivery Securities for original issue in the aggregate principal
amount of up to $150,000,000 aggregate principal amount upon receipt of a written order or orders of the Company signed by an Officer of the Company (a “Company Order”). The initial Company Order shall specify the amount of Securities to
be authenticated, shall provide that all such securities will be represented by a Restricted Global Security and the date on which each original issue of Securities is to be authenticated. 
 (f) Upon receipt of a Company Order, the Authenticating Agent shall authenticate Securities not bearing the Restricted Legend to be issued to the
transferee when sold pursuant to an effective registration statement under the Securities Act as set forth in Section 2.12. 
 (g)
Citibank, N.A. shall act as the initial authenticating agent (the “Authenticating Agent”). 
 (h) The Securities shall be issuable
only in registered form without coupons and only in denominations of $1,000 principal amount and any integral multiple thereof. 
 Section 2.03 Registrar, Transfer Agent, Paying Agent and Conversion Agent. 
 (a) The Company shall maintain one or more
offices or agencies where Securities may be presented for registration of transfer or for exchange (each, a “Transfer Agent”), one or more offices or agencies where the register of Securities and their transfer and exchange shall be kept
(each, a “Registrar”), one or more offices or agencies where Securities may be presented for payment (each, a “Paying Agent”), one or more offices or agencies where Securities may be presented for conversion (each, a
“Conversion Agent”) and one or more offices or agencies where notices and demands to or upon the Company in respect of the Securities and this Indenture may be served. The Company will at all times maintain a Paying Agent, Conversion
Agent, Transfer Agent, Registrar and an office or agency where notices and demands to or upon the Company in respect of the Securities and this Indenture may be served in the Borough of Manhattan, The City of New York. The Company shall provide
written notice to the Trustee of any Agent that is not also the Trustee. The term Registrar includes any co-Registrar; the term Paying Agent includes any additional Paying Agent; the term Transfer Agent includes any co-Transfer Agent; and the term
Conversion Agent includes any additional Conversion Agents. 
  

 14 

 (b) The Company shall enter into an appropriate agency agreement with any Agent not a party to this
Indenture, provided that the Agent may be an Affiliate of the Trustee or the Initial Agent. The agreement shall implement the provisions of this Indenture that relate to such Agent. The Company shall notify the Trustee of the name and address
of any Agent not a party to this Indenture. If the Company fails to maintain a Registrar, Transfer Agent, Paying Agent, Conversion Agent, or agent for service of notices and demands in any place required by this Indenture, or fails to give the
foregoing notice, the Trustee shall act as such. The Company or any Affiliate of the Company may act as Paying Agent (except for the purposes of Section 6.01 and Article 10). 
 (c) The Company hereby initially designates Citibank, N.A. as Paying Agent, Transfer Agent, Registrar, Securities Custodian and Conversion Agent, and
designates the Corporate Trust Office of the Trustee as an office or agency where notices and demands to or upon the Company in respect of the Securities and this Indenture shall be served. 
 Section 2.04 Paying Agent to Hold Money in Trust. 
 (a) Prior to 12:00 p.m. (noon), New York City time, on the Business Day prior to each due date of the payment of principal of, or interest on, any Securities, the Company shall deposit with the Paying Agent a sum
sufficient to pay such principal or interest so becoming due. Subject to Section 9.02, a Paying Agent shall hold in trust for the benefit of Holders of Securities or the Trustee all money held by the Paying Agent for the payment of principal
of, or interest on, the Securities, and shall notify the Trustee of any failure by the Company (or any other obligor on the Securities) to make any such payment. If the Company or an Affiliate of the Company acts as Paying Agent, it shall, before
12:00 p.m.(noon), New York City time, on each due date of the principal of, or interest on, any Securities, segregate the money and hold it as a separate trust fund. The Company at any time may require a Paying Agent to pay all money held by it to
the Trustee, and the Trustee may at any time during the continuance of any Default, upon written request to a Paying Agent, require such Paying Agent to pay forthwith to the Trustee all sums so held in trust by such Paying Agent. Upon doing so, the
Paying Agent (other than the Company) shall have no further liability for the money. 
 (b) The Paying Agent will not be liable to the
Company or any Holder or owner of a beneficial interest in the Securities for interest on funds deposited with it, except as agreed in writing with the Company. 
 Section 2.05 Lists of Holders of Securities. The Registrar shall preserve in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of Holders of
Securities. If the Initial Agent is not the Registrar, the Company shall furnish to the Trustee and the Initial Agent on or before each Interest Payment Date and at such other times as the Trustee or the Initial Agent may request in writing, a list
in such form and as of such date as the Trustee or the Initial Agent may reasonably require of the names and addresses of Holders of Securities. 
  

 15 

 Section 2.06 Transfer and Exchange. 
 (a) Subject to compliance with any applicable additional requirements contained in Section 2.12, when a Security is presented to a Transfer Agent
with a request to register a transfer thereof or to exchange such Security for an equal principal amount of Securities of other authorized denominations, the Transfer Agent shall make the exchange as requested and the Registrar shall register the
transfer or exchange as requested; provided, however, that every Security presented or surrendered for registration of transfer or exchange shall be duly endorsed or accompanied by an assignment form and, if applicable, a transfer certificate
each in the form included in Exhibit A, and completed in a manner satisfactory to the Transfer Agent and the Registrar and duly executed by the Holder thereof or its attorney duly authorized in writing. To permit registration of transfers and
exchanges, upon surrender of any Security for registration of transfer or exchange at an office or agency maintained pursuant to Section 2.03, the Company shall execute and the Authenticating Agent shall authenticate Securities of a like
aggregate principal amount at the Transfer Agent’s request. Any exchange or transfer shall be without charge, except that the Company or the Transfer Agent may require payment of a sum sufficient to cover any tax or other governmental charge
that may be imposed in relation thereto; provided that this sentence shall not apply to any exchange pursuant to Section 2.10, 2.12(a), 3.05, 4.02(e) or 11.05. 
 (b) Neither the Company, any Registrar, the Transfer Agent nor the Trustee shall be required to exchange or register a transfer of any Securities or
portions thereof in respect of which a Fundamental Change Purchase Notice has been delivered and not withdrawn by the Holder thereof (except, in the case of the purchase of a Security in part, the portion thereof not to be purchased). 
 (c) All Securities issued upon any transfer or exchange of Securities shall be valid obligations of the Company, evidencing the same debt and entitled to
the same benefits under this Indenture, as the Securities surrendered upon such transfer or exchange. 
 (d) Any Registrar appointed pursuant
to Section 2.03 shall provide to the Trustee and each Agent such information as the Trustee or such Agent may reasonably require in connection with the delivery by such Registrar of Securities upon transfer or exchange of Securities.

 (e) Each Holder of a Security agrees to indemnify and hold harmless the Company, each Agent and the Trustee against any liability that may
result from the transfer, exchange or assignment of such Holder’s Security in violation of any provision of this Indenture and/or applicable United States federal or state securities law. 
 (f) Neither the Trustee nor any Agent shall have an obligation or duty to monitor, determine or inquire as to compliance with any restrictions on
transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Security (including any transfers between or among Agent Members or other beneficial owners of interests in any Global Security) other
than to require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial compliance
as to form with the express requirements hereof. 
  

 16 

 Section 2.07 Replacement Securities. 
 (a) If any mutilated Security is surrendered to the Company, a Transfer Agent, a Registrar or the Trustee, and the Company, a Transfer Agent, a Registrar
and the Trustee receive evidence to their satisfaction of the destruction, loss or theft of any Security, and there is delivered to the Company, the applicable Transfer Agent and the Trustee such security or indemnity as will be required by them to
save each of them harmless, then, in the absence of notice to the Company, such Transfer Agent or the Trustee that such Security has been acquired by a bona fide purchaser, the Company shall execute, and upon the Company’s written request the
Authenticating Agent shall authenticate and deliver, in exchange for any such mutilated Security or in lieu of any such destroyed, lost or stolen Security, a new Security of like tenor and principal amount, bearing a number not contemporaneously
outstanding. 
 (b) If any such mutilated, destroyed, lost or stolen Security has become or is about to become due and payable, or is about
to be purchased by the Company pursuant to Article 3, or converted pursuant to Article 4, the Company in its discretion may, instead of issuing a new Security, pay, purchase or convert such Security, as the case may be. 
 (c) Upon the issuance of any new Securities under this Section 2.07, the Company may require the payment of a sum sufficient to cover any tax or
other governmental charge that may be imposed in relation thereto and any other reasonable expenses (including the reasonable fees and expenses of the Trustee or the Registrar) in connection therewith. 
 (d) Every new Security issued pursuant to this Section 2.07 in lieu of any mutilated, destroyed, lost or stolen Security shall constitute an
original additional contractual obligation of the Company, whether or not the mutilated, destroyed, lost or stolen Security shall be at any time enforceable by anyone, and shall be entitled to all benefits of this Indenture equally and
proportionately with any and all other Securities duly issued hereunder. 
 (e) The provisions of this Section 2.07 are (to the extent
lawful) exclusive and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Securities. 
 Section 2.08 Outstanding Securities. 
 (a) Securities outstanding at any time are all Securities authenticated by the Authenticating Agent, except for those canceled by it, those purchased pursuant to Article 3, those converted pursuant to Article 4, those accepted by the
Trustee for cancellation or surrendered for transfer or exchange and those described in this Section 2.08 as not outstanding. 
 (b) If
a Security is replaced pursuant to Section 2.07, it ceases to be outstanding unless the Company receives proof satisfactory to it that the replaced Security is held by a bona fide purchaser. 
 (c) If a Paying Agent (other than the Company or an Affiliate of the Company) holds in respect of the outstanding Securities on the Business Day
following a Fundamental Change Purchase Date or the Final Maturity Date money sufficient to pay the principal of (including premium, if any) and accrued interest on Securities (or portions thereof) 
  

 17 

 payable on that date, then on and after such Fundamental Change Purchase Date or Final Maturity Date, as the case may be,
such Securities (or portions thereof, as the case may be) shall cease to be outstanding and cash interest on them shall cease to accrue. 
 (d) Subject to the restrictions contained in Section 2.09, a Security does not cease to be outstanding because the Company or an Affiliate of the Company holds the Security. 
 Section 2.09 Treasury Securities. In determining whether the Holders of the required principal amount of Securities have concurred in any
notice, direction, waiver or consent, Securities owned by the Company or any other obligor on the Securities or by any Affiliate of the Company or of such other obligor shall be disregarded, except that, for purposes of determining whether the
Trustee shall be protected in relying on any such notice, direction, waiver or consent, only Securities which a Trust Officer of the Trustee with responsibility for this Indenture actually knows are so owned shall be so disregarded. Securities so
owned which have been pledged in good faith shall not be disregarded if the pledgee establishes to the satisfaction of the Trustee or an Agent, as applicable, the pledgee’s right so to act with respect to the Securities and that the pledgee is
not the Company or any other obligor on the Securities or any Affiliate of the Company or of such other obligor. If the pledgee’s right to so act is in dispute the Trustee or the applicable Agent may rely on the advice of counsel or an
Officer’s Certificate and shall have no liability for actions taken in reliance thereon. 
 Section 2.10 Temporary
Securities. Until definitive Securities are ready for delivery, the Company may prepare and execute, and, upon receipt of a Company Order, the Authenticating Agent shall authenticate and deliver, temporary Securities. Temporary Securities shall
be substantially in the form of definitive securities but may have variations that the Company with the consent of the Trustee considers appropriate for temporary Securities. Without unreasonable delay, the Company shall prepare and the
Authenticating Agent shall authenticate and deliver definitive Securities in exchange for temporary Securities. 
 Section 2.11
Cancellation. The Company at any time may deliver Securities to the Transfer Agent for cancellation. The Registrar, the Paying Agent and the Conversion Agent shall forward to the Transfer Agent or its agent any Securities surrendered to them
for transfer, exchange, purchase, payment or conversion. The Transfer Agent and no one else shall cancel, in accordance with its standard procedures, all Securities surrendered for transfer, exchange, purchase, payment, conversion or cancellation
and shall dispose of the cancelled Securities in accordance with its customary procedures or deliver the canceled Securities to the Company. All Securities which are purchased or otherwise acquired by the Company or any of its Subsidiaries prior to
the Final Maturity Date pursuant to Article 3 shall be delivered to the Transfer Agent for cancellation, and the Company may not hold or resell such Securities or issue any new Securities to replace any such Securities or any Securities that any
Holder has converted pursuant to Article 4. 
 Section 2.12 Restricted Legend; Additional Transfer and Exchange Requirements.

 (a) If Securities are issued upon the transfer, exchange or replacement of Securities subject to restrictions on transfer and bearing the
restricted legend set forth on the form of Securities attached as Exhibit A and called for by footnote 2 thereof (the “Restricted 
  

 18 

 Legend”), or if a request is made to remove the Restricted Legend on a Security, the Securities so issued shall bear
the Restricted Legend, or the Restricted Legend shall not be removed, as the case may be, unless (i) the requested transfer is after the Resale Restriction Termination Date, (ii) there is delivered to the Company, the Trustee, the Transfer
Agent and the Registrar such satisfactory evidence, which shall include an Opinion of Counsel if requested by the Company, the Trustee, the Transfer Agent or such Registrar, as may be reasonably required by the Company, the Trustee, the Transfer
Agent and the Registrar, that neither the Restricted Legend nor the restrictions on transfer set forth therein are required to ensure that transfers thereof comply with the Securities Act or that such Securities are not “restricted” within
the meaning of Rule 144 under the Securities Act, or (iii) such Security has been sold pursuant to an effective registration statement under the Securities Act and the Holder selling such Securities has delivered to the Registrar and the
Transfer Agent a notice in the form of Exhibit B hereto. Upon effectiveness, under the Securities Act, of the “Shelf Registration Statement” (as defined in the Registration Rights Agreement), the Company shall deliver to the Trustee
and the Agents a notice of effectiveness, a Global Security or Securities which does not bear the Restricted Legend, an authentication order in accordance with Section 2.02 and an Opinion of Counsel in the form of Exhibit C hereto, and,
if required by the Depositary, the Company shall deliver to the Depositary a letter of representations in a form reasonably acceptable to the Depositary. Upon the effectiveness of any post-effective amendment to the “Shelf Registration
Statement” and upon the effectiveness, under the Securities Act of any subsequent Shelf Registration Statement related to the Securities, the Company shall deliver to the Trustee and the Agents a notice of effectiveness and an Opinion of
Counsel in the form of Exhibit C hereto. Upon any sale, pursuant to a Shelf Registration Statement, of a beneficial interest in a Global Security that theretofore constituted a Restricted Security and delivery of appropriate evidence thereof
to the Trustee and the Agents, and upon any sale or transfer of a beneficial interest in connection with which the Restricted Legend will be removed in accordance with this Indenture, the appropriate Agent shall increase the principal amount of the
Global Security that does not constitute a Restricted Security by the principal amount of such sale or transfer and likewise reduce the principal amount of the Global Security that does constitute a Restricted Security. The Trustee and the Agents
shall not be liable for any action taken or omitted to be taken by it in good faith in accordance with the aforementioned Opinion of Counsel or registration statement. 
 (b) A Global Security may not be transferred, in whole or in part, to any Person other than the Depositary or a nominee or any successor thereof, and no such transfer to any such other Person may be registered;
provided that the foregoing shall not prohibit any transfer of a Security that is issued in exchange for a Global Security but is not itself a Global Security. No transfer of a Security to any Person shall be effective under this Indenture or
the Securities unless and until such Security has been registered in the name of such Person. Notwithstanding any other provisions of this Indenture or the Securities, transfers of a Global Security, in whole or in part, shall be made only in
accordance with this Section 2.12. 
 (c) Subject to Section 2.12(b) and in compliance with Section 2.12(d), every Security
shall be subject to the restrictions on transfer provided in the Legend. Whenever any Restricted Security other than a Restricted Global Security is presented or surrendered for registration of transfer or in exchange for a Security registered in a
name other than that of the Holder, such Security must be accompanied by a certificate in substantially the form set forth in Exhibit A, dated the date of such surrender and signed by the Holder of such Security, as to 
  

 19 

 compliance with such restrictions on transfer. The Registrar shall not be required to accept for such registration of
transfer or exchange any Security not so accompanied by a properly completed certificate. 
 As used in Sections 2.12(c), the term
“transfer” encompasses any sale, pledge, transfer, hypothecation or other disposition of any Security. 
 (d) The provisions below
shall apply only to Global Securities: 
 (1) Each Global Security authenticated under this Indenture shall be registered in
the name of the Depositary or a nominee thereof and delivered to such Depositary or a nominee thereof or custodian therefor, and each such Global Security shall constitute a single Security for purposes of this Indenture. 
 (2) Notwithstanding any other provisions of this Indenture or the Securities, a Global Security shall not be exchanged in whole or in part
for a Security registered, and no transfer of a Global Security in whole or in part shall be registered in the name of any Person other than the Depositary or one or more nominees thereof; provided that a Global Security may be exchanged for
securities registered in the names of any person designated by the Depositary in the event that (A) the Depositary has notified the Company that it is unwilling or unable to continue as Depositary for such Global Security or such Depositary has
ceased to be a “clearing agency” registered under the Exchange Act, and a successor Depositary is not appointed by the Company within 90 days after receiving such notice or becoming aware that the Depositary has ceased to be a
“clearing agency,” or (B) an Event of Default has occurred and is continuing with respect to the Securities. Any Global Security exchanged pursuant to subclause (A) above shall be so exchanged in whole and not in part, and any
Global Security exchanged pursuant to subclause (B) above may be exchanged in whole or from time to time in part as directed by the Depositary. Any Security issued in exchange for a Global Security or any portion thereof shall be a Global
Security; provided further that any such Security so issued that is registered in the name of a Person other than the Depositary or a nominee thereof shall not be a Global Security. 
 (3) Securities issued in exchange for a Global Security or any portion thereof shall be issued in definitive, fully registered form,
without interest coupons, shall have an aggregate principal amount equal to that of such Global Security or portion thereof to be so exchanged, shall be registered in such names and be in such authorized denominations as the Depositary shall
designate and shall bear the applicable legends provided for herein. Any Global Security to be exchanged in whole shall be surrendered by the Depositary to the Registrar. With regard to any Global Security to be exchanged in part, either such Global
Security shall be so surrendered for exchange or, if the Registrar is acting as custodian for the Depositary or its nominee with respect to such Global Security, the principal amount thereof shall be reduced, by an amount equal to the portion
thereof to be so exchanged, by means of an appropriate adjustment made on the records of the Securities Custodian. Upon any such surrender or adjustment, the Authenticating Agent shall authenticate and deliver the Security issuable on such exchange
to or upon the order of the Depositary or an authorized representative thereof. 
  

 20 

 (4) Subject to Section 2.01(b), the registered Holder may grant proxies and
otherwise authorize any Person, including Agent Members and Persons that may hold interests through Agent Members, to take any action which a Holder is entitled to take under this Indenture or the Securities. 
 (5) In the event of the occurrence of the events specified in clause (2) of this Section 2.12(d), the Company will promptly make
available to the Transfer Agent a reasonable supply of Certificated Securities in definitive, fully registered form, without interest coupons. 
 (6) At such time as all interests in a Global Security have been converted, cancelled or exchanged for Securities in certificated form, such Global Security shall, upon receipt thereof, be cancelled by the Transfer
Agent in accordance with standing procedures and instructions existing between the Depositary and the Securities Custodian, subject to Section 2.11 of this Indenture. At any time prior to such cancellation, if any interest in a Global Security
is converted, canceled or exchanged for Securities in certificated form, the principal amount of such Global Security shall, in accordance with the standing procedures and instructions existing between the Depositary and the Securities Custodian, be
appropriately reduced, and an endorsement shall be made on such Global Security, by the Securities Custodian, at the direction of the Transfer Agent, to reflect such reduction. 
 Section 2.13 CUSIP Numbers. The Company in issuing the Securities may use one or more “CUSIP” numbers (if then generally in use),
and, if so, the Trustee and the Agents shall use “CUSIP” numbers in notices of purchase as a convenience to Holders; provided that any such notice may state that no representation is made as to the correctness of such numbers either
as printed on the Securities or as contained in any notice of a purchase and that reliance may be placed only on the other identification numbers printed on the Securities, and any such purchase shall not be affected by any defect in or omission of
such numbers. The Company will promptly notify the Trustee and the Agents of any change in the “CUSIP” numbers. 
 ARTICLE 3

 PURCHASE 
 Section 3.01 Purchase of Securities at Option of the Holder upon a Fundamental Change. 
 (a) If a Fundamental Change
occurs prior to the Final Maturity Date, each Holder of a Security shall have the right, at the option of the Holder, to require the Company to repurchase for cash all or any portion of the Securities of such Holder equal to $1,000 principal amount
(or an integral multiple thereof) at the Fundamental Change Purchase Price, on the date that is not less than 30 days nor more than 45 days after the date of the Fundamental Change Company Notice pursuant to subsection 3.01(b) (the “Fundamental
Change Purchase Date”). 
 (b) As soon as practicable following the announcement of a Fundamental Change, but in no event later than 3
Trading Days prior to the anticipated Fundamental Change 
  

 21 

 Effective Date, the Company shall mail a written notice of the Fundamental Change and of the resulting repurchase right
to the Trustee, Paying Agent and to each Holder (and to beneficial owners as required by applicable law) (the “Fundamental Change Company Notice”). The Fundamental Change Company Notice shall include the form of a Fundamental Change
Purchase Notice to be completed by the Holder and shall state: 
 (1) the events causing such Fundamental Change; 

(2) the date (or expected date) of such Fundamental Change; 
 (3) the last date by which the Fundamental Change Purchase Notice must be delivered to elect the repurchase option pursuant to this
Section 3.01; 
 (4) the Fundamental Change Purchase Date; 
 (5) the Fundamental Change Purchase Price; 
 (6) the Holder’s right to require the Company to purchase the Securities; 
 (7) the name
and address of each Paying Agent and Conversion Agent; 
 (8) the then effective Conversion Rate and any adjustments to the
Conversion Rate resulting from such Fundamental Change; 
 (9) the procedures that the Holder must follow to exercise rights
under Article 4 and that Securities as to which a Fundamental Change Purchase Notice has been given may be converted into ADSs pursuant to Article 4 of this Indenture only to the extent that the Fundamental Change Purchase Notice has been withdrawn
in accordance with the terms of this Indenture; 
 (10) the procedures that the Holder must follow to exercise rights under
this Section 3.01; 
 (11) the procedures for withdrawing a Fundamental Change Purchase Notice; 
 (12) that, unless the Company fails to pay such Fundamental Change Purchase Price, Securities covered by any Fundamental Change Purchase
Notice will cease to be outstanding and interest and Additional Interest, if any, will cease to accrue on and after the Fundamental Change Purchase Date; and 
 (13) the CUSIP number of the Securities. 
 At the Company’s request, the Trustee shall give such Fundamental Change Purchase Notice in the Company’s name and at the Company’s expense; provided, that, in all cases, the text of such
Fundamental Change Purchase Notice shall be prepared by the Company. If any of the Securities is in the form of a Global Security, then the Company shall modify such notice to the extent necessary to accord with the Applicable Procedures relating to
the purchase of Global Securities. 
  

 22 

 (c) A Holder may exercise its rights specified in Section 3.01(a) upon delivery of a written notice
(which shall be in substantially the form attached as Exhibit A under the heading “Fundamental Change Purchase Notice” and which may be delivered by letter, overnight courier, hand delivery, facsimile transmission or in any other
written form and, in the case of Global Securities, may be delivered electronically or by other means in accordance with the Depositary’s Applicable Procedures) of the exercise of such rights (a “Fundamental Change Purchase Notice”)
to the Company or any Paying Agent at any time prior to the close of business in the City of New York on the Business Day next preceding the Fundamental Change Purchase Date, subject to extension to comply with applicable law. 
 (1) The Fundamental Change Purchase Notice shall state: (A) the certificate number (if such Security is held other than in global
form) of the Security which the Holder will deliver to be purchased (or, if the Security is held in global form, any other items required to comply with the Applicable Procedures), (B) the portion of the principal amount of the Security which
the Holder will deliver to be purchased and (C) that such Security shall be purchased as of the Fundamental Change Purchase Date pursuant to the terms and conditions specified in the Securities and in this Indenture. 
 (2) The delivery of a Security for which a Fundamental Change Purchase Notice has been timely delivered to any Paying Agent and not
validly withdrawn prior to, on or after the Fundamental Change Purchase Date (together with all necessary endorsements) at the office of such Paying Agent shall be a condition to the receipt by the Holder of the Fundamental Change Purchase Price
therefor. 
 (3) The Company shall only be obliged to purchase, pursuant to this Section 3.01, a portion of a Security if
the principal amount of such portion is $1,000 or an integral multiple of $1,000 (provisions of this Indenture that apply to the purchase of all of a Security also apply to the purchase of such portion of such Security). 
 (4) Notwithstanding anything herein to the contrary, any Holder delivering to a Paying Agent the Fundamental Change Purchase Notice
contemplated by this Section 3.01(c) shall have the right to withdraw such Fundamental Change Purchase Notice in whole or in a portion thereof that is a principal amount of $1,000 or in an integral multiple thereof at any time prior to the
close of business in the City of New York on the Business Day prior to the Fundamental Change Purchase Date by delivery of a written notice of withdrawal to the Paying Agent in accordance with Section 3.02. 
 (5) A Paying Agent shall promptly notify the Company of the receipt by it of any Fundamental Change Purchase Notice or written withdrawal
thereof. 
 (6) Anything herein to the contrary notwithstanding, in the case of Global Securities, any Fundamental Change
Purchase Notice may be delivered or withdrawn and such Securities may be surrendered or delivered for purchase in accordance with the Applicable Procedures as in effect from time to time. 
  

 23 

 Section 3.02 Effect of Fundamental Change Purchase Notice. 
 (a) Upon receipt by any Paying Agent of a properly completed Fundamental Change Purchase Notice from a Holder, the Holder of the Security in respect of
which such Fundamental Change Purchase Notice was given shall (unless such Fundamental Change Purchase Notice is withdrawn as specified in Section 3.02(b)) thereafter be entitled to receive the Fundamental Change Purchase Price with respect to
such Security, subject to the occurrence of the Fundamental Change Effective Date and an absence of an Event of Default, or a continuation thereof (other than a Default in the payment of the Fundamental Change Purchase Price). Such Fundamental
Change Purchase Price shall be paid to such Holder promptly following the later of (1) the Fundamental Change Purchase Date (provided that the conditions in Section 3.01 have been satisfied) and (2) the time of delivery of such
Security to a Paying Agent by the Holder thereof in the manner required by Section 3.01(c). Securities in respect of which a Fundamental Change Purchase Notice has been given by the Holder thereof may not be converted into ADSs pursuant to
Article 4 on or after the date of the delivery of such Fundamental Change Purchase Notice unless such Fundamental Change Purchase Notice has first been validly withdrawn in accordance with Section 3.02(b) with respect to the Securities to be
converted. 
 (b) A Fundamental Change Purchase Notice may be withdrawn by means of a written notice (which may be delivered by mail,
overnight courier, hand delivery, facsimile transmission or in any other written form and, in the case of Global Securities, may be delivered by other means in accordance with the Applicable Procedures) of withdrawal delivered by the Holder to a
Paying Agent at any time prior to the close of business in the City of New York on the Business Day immediately prior to the Fundamental Change Purchase Date, specifying (1) the principal amount of the Security or portion thereof (which must be
a principal amount of $1,000 or an integral multiple of $1,000 in excess thereof) with respect to which such notice of withdrawal is being submitted, (2) if certificated Securities have been issued, the certificate number of the Security being
withdrawn in whole or in withdrawable part (or if the Securities are not certificated, such written notice must comply with the Applicable Procedures) and (3) the portion of the principal amount of the Security that will remain subject to the
Fundamental Change Purchase Notice, which portion must be a principal amount of $1,000 or an integral multiple thereof. 
 Section 3.03
Deposit of Fundamental Change Purchase Price. 
 (a) On or before 12:00 p.m. (noon) New York City time on the Business Day following
the applicable Fundamental Change Purchase Date, the Company shall deposit with the Trustee or with a Paying Agent (or if the Company or an Affiliate of the Company is acting as the Paying Agent, shall segregate and hold in trust as provided in
Section 2.04) an amount of money (in immediately available funds if deposited on or after such Fundamental Change Purchase Date), sufficient to pay the aggregate Fundamental Change Purchase Price of all the Securities or portions thereof that
are to be purchased as of such Fundamental Change Purchase Date. 
 (b) If a Paying Agent or the Trustee holds, in accordance with the terms
hereof, money sufficient to pay the Fundamental Change Purchase Price of any Security for which a Fundamental Change Purchase Notice has been tendered and not withdrawn in 
  

 24 

 accordance with this Indenture then, on the Business Day following the applicable Fundamental Change Purchase Date, such
Security will cease to be outstanding, whether or not the Security is delivered to the Paying Agent or the Trustee, and interest shall cease to accrue, and the rights of the Holder in respect of the Security shall terminate (other than the right to
receive the Fundamental Change Purchase Price as aforesaid). The Company shall publicly announce the principal amount of Securities repurchased on or as soon as practicable after the Fundamental Change Purchase Date. 
 (c) The Paying Agent will promptly return to the respective Holders thereof any Securities with respect to which a Fundamental Change Purchase Notice has
been withdrawn in compliance with this Indenture. 
 (d) If a Fundamental Change Purchase Date falls after a Regular Record Date and on or
before the related Interest Payment Date, then interest on the Securities payable on such Interest Payment Date will be payable to the Holders in whose names the Securities are registered at the close of business on such Regular Record Date.

 Section 3.04 Repayment to the Company. To the extent that the aggregate amount of cash deposited by the Company pursuant to
Section 3.03 exceeds the aggregate Fundamental Change Purchase Price of the Securities or portions thereof that the Company is obligated to purchase, then promptly after the Fundamental Change Purchase Date the Trustee or a Paying Agent, as the
case may be, shall return any such excess cash to the Company. 
 Section 3.05 Securities Purchased in Part. Any Security that is
to be purchased only in part shall be surrendered at the office of a Paying Agent, and promptly after the Fundamental Change Purchase Date, the Company shall execute and the Authenticating Agent shall authenticate and deliver to the Holder of such
Security, without service charge, a new Security or Securities, of such authorized denomination or denominations as may be requested by such Holder (which must be equal to $1,000 principal amount or any integral thereof), in aggregate principal
amount equal to, and in exchange for, the portion of the principal amount of the Security so surrendered that is not purchased. 
 Section 3.06 Compliance with Securities Laws upon Purchase of Securities. In connection with any offer to purchase of Securities under Section 3.01, the Company shall (a) comply with Rule 13e-4 and Rule 14e-1 (or any
successor to either such Rule), and any other tender offer rules, if applicable, under the Exchange Act, (b) file the related Schedule TO (or any successor or similar schedule, form or report) if required under the Exchange Act, and
(c) otherwise comply with all federal and state securities laws in connection with such offer to purchase or purchase of Securities, all so as to permit the rights of the Holders and obligations of the Company under Sections 3.01 through 3.04
to be exercised in the time and in the manner specified therein. To the extent that compliance with any such laws, rules and regulations would result in a conflict with any of the terms hereof, this Indenture is hereby modified to the extent
required for the Company to comply with such laws, rules and regulations. 
 Section 3.07 Purchase of Securities in Open Market.
The Company may repurchase Securities in the open market, by tender at any price or by negotiated transactions. The Company may surrender any Security purchased by the Company pursuant to this Article 3 to 
  

 25 

 the Transfer Agent for cancellation. Any securities surrendered to the Transfer Agent for cancellation may not be
reissued or resold by the Company and will be canceled promptly in accordance with Section 2.11. 
 ARTICLE 4 
 CONVERSION 
 Section 4.01
Conversion Privilege and Conversion Rate. 
 (a) Subject to and upon compliance with the provisions of this Article 4, at the option of
the Holder thereof, any Security or portion thereof that is an integral multiple of $1,000 principal amount may be converted into fully paid and non-assessable ADSs (calculated as to each conversion to the nearest 1/100th of an ADS) of the Company at any time prior to the close of business on the Business Day immediately preceding the Final
Maturity Date or such earlier date set forth in this Article 4, unless purchased by the Company at the Holder’s option, at the Conversion Rate in effect at such time, determined as hereinafter provided. Upon conversion of a Security pursuant to
the provisions of this Article 4, in lieu of delivering ADSs, the Company may, pursuant to Section 4.13, satisfy its conversion obligations hereunder with cash or a combination of cash and ADSs. 
 (b) Provisions of this Indenture that apply to conversion of all of a Security also apply to conversion of a portion of a Security. 
 (c) A Holder of Securities is not entitled to any rights of a holder of ADSs until such Holder has converted its Securities into ADSs, and only to the
extent such Securities are deemed to have been converted into ADSs pursuant to this Article 4. 
 (d) The Conversion Rate shall be adjusted
in certain instances as provided in Section 4.01(e) and Section 4.06. 
 (e) If there shall have occurred a Fundamental Change, the
Company shall pay a “Make Whole Premium” to the Holders of the Securities who convert their Securities during the period beginning 10 Trading Days before the date the Company announces as the anticipated Fundamental Change Effective Date
and ending at the close of business on the Trading Day immediately preceding the Fundamental Change Purchase Date by issuing additional ADSs for such Securities. The number of additional ADSs per $1,000 principal amount of Securities constituting
the Make Whole Premium shall be determined by the Company by reference to the table below, based on the Fundamental Change Effective Date and the ADS Price of such Fundamental Change; provided that if the ADS Price or Fundamental Change
Effective Date are not set forth on the table: (i) if the actual ADS Price on the Fundamental Change Effective Date is between two ADS Prices on the table or the actual Fundamental Change Effective Date is between two Fundamental Change
Effective Dates on the table, the Make Whole Premium will be determined by a straight-line interpolation between the Make Whole Premiums set forth for the two ADS Prices and the two Fundamental Change Effective Dates on the table based on a 365-day
year, as applicable, (ii) if the ADS Price on the Fundamental Change Effective Date exceeds $100.00 per ADS, subject to adjustment as set forth 
  

 26 

 herein, no Make Whole Premium will be paid, and (iii) if the ADS Price on the Fundamental Change Effective Date is
less than $25.78 per ADS, subject to adjustment as set forth herein, no Make Whole Premium will be paid. If Holders of Ordinary Shares receive only cash in the Fundamental Change, the ADS Price shall be the cash amount paid per Ordinary Share in
connection with the Fundamental Change, multiplied by the number of Ordinary Shares then represented by each ADS. Otherwise, the ADS Price shall be equal to the average Closing Sale Prices of the ADSs for each of the 10 Trading Days immediately
preceding, but not including, the applicable Fundamental Change Effective Date. 
 Make Whole Premium upon a Fundamental Change

 (Number of Additional ADSs) Effective Date 
  

													
	 ADS Price
	  	November 21,
2006	  	November 15,
2007	  	November 15,
2008	  	November 15,
2009	  	November 15,
2010	  	November 15,
2011
	 $25.78
	  	7.7579	  	7.7579	  	7.7579	  	7.7579	  	7.7579	  	0.0000
	 $27.50
	  	6.8579	  	6.3793	  	5.8868	  	5.3930	  	4.9558	  	0.0000
	 $30.00
	  	5.8540	  	5.3049	  	4.7017	  	4.0284	  	3.2360	  	0.0000
	 $35.00
	  	4.5348	  	3.9507	  	3.2865	  	2.5098	  	1.5322	  	0.0000
	 $40.00
	  	3.7320	  	3.1768	  	2.5463	  	1.8199	  	0.9566	  	0.0000
	 $45.00
	  	3.1981	  	2.6899	  	2.1168	  	1.4727	  	0.7533	  	0.0000
	 $50.00
	  	2.8212	  	2.3537	  	1.8451	  	1.2764	  	0.6588	  	0.0000
	 $55.00
	  	2.5409	  	2.1148	  	1.6554	  	1.1443	  	0.5951	  	0.0000
	 $60.00
	  	2.3157	  	1.9262	  	1.5070	  	1.0429	  	0.5447	  	0.0000
	 $65.00
	  	2.1305	  	1.7714	  	1.3866	  	0.9603	  	0.5027	  	0.0000
	 $70.00
	  	1.9744	  	1.6413	  	1.2853	  	0.8908	  	0.4667	  	0.0000
	 $75.00
	  	1.8406	  	1.5299	  	1.1985	  	0.8309	  	0.4355	  	0.0000
	 $100.00
	  	1.3773	  	1.1443	  	0.8977	  	0.6220	  	0.3265	  	0.0000

 The ADS Prices set forth in the first column of the table above will be adjusted as of any date on
which the Conversion Rate of the Securities is adjusted. The adjusted ADS Prices will equal the ADS Prices applicable immediately prior to such adjustment multiplied by a fraction, the numerator of which is the Conversion Rate immediately prior to
the adjustment giving rise to the ADS Price adjustment and the denominator of which is the Conversion Rate as so adjusted. The number of additional ADSs set forth in the table above will be adjusted in the same manner as the Conversion Rate as set
forth in Section 4.06 hereof, other than as a result of an adjustment of the Conversion Rate by adding the Make Whole Premium as described above. 
 Notwithstanding the foregoing paragraph, in no event will the total number of ADSs issuable upon conversion of a Security exceed 38.7897 per $1,000 principal amount of Securities, subject to proportional
adjustment in the same manner as the Conversion Rate as set forth in clauses (1) through (4) of Section 4.06(a) hereof. 
 The
additional ADSs issuable pursuant to this Section 4.01(e) shall be delivered upon the later of (i) the settlement date for the conversion and (ii) promptly following the Fundamental Change Effective Date. 
 (f) By delivering to the depositary under the Deposit Agreement the number of Ordinary Shares represented by the ADSs issuable on conversion of the
Securities and/or cash in lieu of such Ordinary Shares, together with any cash payment for such Holder’s fractional ADSs, if any, the Company will be deemed to have satisfied its obligation to pay the principal 
  

 27 

 amount of the Securities so converted and its obligation to pay accrued and unpaid interest, and Additional Interest, if
any, attributable to the period from the most recent Interest Payment Date through the Conversion Date (which amount will be deemed paid in full rather than cancelled, extinguished or forfeited). 
 (g) The Trustee and the Paying Agent may conclusively rely on the Company’s calculations of the Make Whole Premium. 
 (h) If the Company’s ADS facility maintained with the ADS depositary pursuant to the terms of the Deposit Agreement is terminated for any reason,
but does not constitute a Termination of Trading because the Ordinary Shares are then listed for trading on a U.S. national securities exchange or approved for listing on the Nasdaq Global Select Market or any U.S. system of automated dissemination
of quotations of securities prices, or traded in over-the-counter securities markets, the Securities shall become convertible into, at the discretion of the Company, cash, Ordinary Shares or a combination of Ordinary Shares. In all such case, all
reference to ADSs in this Indenture shall be deemed to refer to Ordinary Shares, all references to the Closing Sale Price of the ADSs will be deemed to refer to the Closing Sale Price of the Ordinary Shares, and other appropriate adjustments will be
made hereunder to reflect such change. If the ADS facility maintained with the ADS depositary pursuant to the terms of the Deposit Agreement is terminated for any reason and such event does constitute a Termination of Trading, then the provisions of
Section 3.01 and Section 4.01(e) of this Indenture shall apply. 
 Section 4.02 Conversion Procedure. 
 (a) To convert a Security, a Holder must (1) complete and manually sign the conversion notice on the back of the Security, copies of which will be
available from the Conversion Agent and deliver a copy of such notice by facsimile with an original to follow to the Conversion Agent, (2) surrender the Security to the Conversion Agent either at its principal corporate office if the Security
has been certificated or by means of electronic book entry transfer, (3) furnish appropriate endorsements and transfer documents if required by a Registrar or a Conversion Agent, (4) if required, deliver interest as set forth in
Section 4.02(c) to the Conversion Agent, (5) if required, furnish to the ADS depositary written acknowledgements, certification and agreements in connection with the issuance of ADSs by the ADS depositary upon deposit of Ordinary Shares,
(6) pay to the appropriate authorities all transfer or similar taxes, if required pursuant to Section 4.04 and (7) prior to the issuance of ADSs, pay the applicable fees of the ADS depositary as described under the Deposit Agreement.
The date on which the Holder satisfies all of those requirements is the “Conversion Date.” Upon the conversion of a Security, the Company will pay the cash and/or deliver the requisite documentation and the Ordinary Shares to the
depositary for the ADS facility, as applicable, as promptly as practicable after the later of the Conversion Date and the date that all calculations necessary to make such payment and delivery have been made, but in no event later than five Business
Days after the later of those dates. Anything herein to the contrary notwithstanding, in the case of Global Securities, conversion notices may be delivered and such Securities may be surrendered for conversion in accordance with the Applicable
Procedures as in effect from time to time. 
  

 28 

 (b) The ADS depositary shall be deemed to be a holder of record of Ordinary Shares deposited upon
conversion on the Conversion Date; provided, however, that no surrender of a Security on any Conversion Date when the share transfer books of the Company shall be closed shall be effective to constitute the ADS depositary entitled to receive
the Ordinary Shares deposited upon conversion as the record holder of such Ordinary Shares on such date, but such surrender shall be effective to constitute such ADS depositary entitled to receive such Ordinary Shares as the record holder thereof
for all purposes at the close of business on the next succeeding day on which such share transfer books are open; provided further that such conversion shall be at the Conversion Rate in effect on the Conversion Date as if the share transfer
books of the Company had not been closed. Upon conversion of a Security, such person shall no longer be a Holder of such Security. Except as set forth in this Indenture, no payment or adjustment will be made for dividends or distributions declared
or made on the Ordinary Shares represented by ADSs issued upon conversion of a Security prior to the issuance of such shares. 
 (c) Holders
of Securities surrendered for conversion (in whole or in part) at the close of business on any Regular Record Date will receive the interest payable on such Securities on the corresponding Interest Payment Date notwithstanding the conversion of such
Securities at any time after the close of business on the applicable Regular Record Date. However, upon surrender of any such Securities for conversion during the period from the close of business on any Regular Record Date to the opening of
business on the next succeeding Interest Payment Date, unless (1) such Securities have been surrendered for conversion following the Regular Record Date immediately preceding the Final Maturity Date, (2) the Company has specified a
Fundamental Change Purchase Date that falls on or after a Regular Record Date and on or prior to the corresponding Interest Payment Date, or (3) to the extent of overdue interest, if any, which exists at the time of the Conversion with respect
to such Security, such Securities shall also be accompanied by payment in funds acceptable to the Company of an amount equal to the interest payable on such corresponding Interest Payment Date. Except as otherwise provided in this
Section 4.02(c), no payment or adjustment will be made for accrued interest on a converted Security. 
 (d) Subject to
Section 4.02(c), nothing in this Section shall affect the right of a Holder in whose name any Security is registered at the close of business on a Regular Record Date to receive the interest payable on such Security on the related Interest
Payment Date in accordance with the terms of this Indenture, the Securities and the Registration Rights Agreement. If a Holder converts more than one Security at the same time, the number of ADSs issuable upon the conversion, if any, (and the amount
of any cash in lieu of fractional shares pursuant to Section 4.03) shall be based on the aggregate principal amount of all Securities so converted. 
 (e) In the case of any Security which is converted in part only, upon such conversion the Company shall execute and the Authenticating Agent shall authenticate and deliver to the Holder thereof, without service
charge, a new Security or Securities of authorized denominations in an aggregate principal amount equal to the, and in exchange for, unconverted portion of the principal amount of such Security. A Security may be converted in part, but only if the
principal amount of such part is an integral multiple of $1,000 and the principal amount of such Security to remain outstanding after such conversion is equal to $1,000 or any integral multiple of $1,000 in excess thereof. 
  

 29 

 Section 4.03 Fractional Shares. The Company will not issue fractional ADSs or securities
representing fractional ADSs upon conversion of Securities. If more than one Security shall be surrendered for conversion at one time by the same Holder, the number of full ADSs that shall be issuable upon conversion shall be computed on the basis
of the aggregate principal amount of the Securities (or specified portions thereof to the extent permitted hereby) so surrendered. In lieu of any fractional ADSs, the Company will pay an amount in cash for the current market value of the fractional
ADSs. The current market value of a fractional ADS shall be determined by multiplying the average of the Closing Sale Price of the ADS on the Trading Day immediately preceding the Conversion Date by such fractional ADS and rounding the product to
the nearest whole cent. 
 Section 4.04 Taxes on Conversion; Additional Amounts. If a Holder converts a Security, the Holder
shall pay any documentary, transfer, stamp or similar taxes or duties related to the issue or delivery of ADSs upon such conversion. The Holder shall also pay any such tax with respect to cash received in lieu of fractional ADSs. In addition, the
Holder shall pay any such tax which is due because the Holder requests the ADSs to be issued in a name other than the Holder’s name. The Conversion Agent may refuse to deliver any certificate, if applicable, representing the ADS being issued in
a name other than the Holder’s name until the Conversion Agent receives certification that all taxes due including any tax which will be due because the ADSs are to be issued in a name other than the Holder’s name have been paid. Nothing
herein shall preclude any tax withholding required by law or regulation within any jurisdiction in which the Company or any successor are organized or resident for tax purposes (each, as applicable, a “Relevant Jurisdiction”), unless such
withholding or deduction is required by law or by regulation or governmental policy having the effect of law. In the event that any such withholding or deduction is so required, the Company shall pay to the Holder of each Security such additional
amounts (“Additional Amounts”) as may be necessary to ensure that the net amount received by the Holder after such withholding or deduction (and after deducting any taxes on the Additional Amounts) shall equal the amounts which would have
been received by such Holder had no such withholding or deduction been required, except that no Additional Amounts shall be payable: 
 (a)
for or on account of: 
 (1) any tax, duty, assessment or other governmental charge that would not have been imposed but for:

 (A) the existence of any present or former connection between the Holder or beneficial owner of such Security, and the
Relevant Jurisdiction other than merely holding such Security or the receipt of payments thereunder, including, without limitation, such Holder or beneficial owner being or having been a national, domiciliary or resident of such Relevant
Jurisdiction or treated as a resident thereof or being or having been physically present or engaged in a trade or business therein or having or having had a permanent establishment therein; 
 (B) the presentation of such Security (in cases in which presentation is required) more than 30 days after the later of the date on which
the payment of the principal of, premium, if any, and interest on, such Security became due and payable pursuant to the terms thereof or was made or duly provided for; or 
  

 30 

 (C) the failure of the Holder or beneficial owner to comply with a timely request from
the Company or any successor, addressed to the Holder or beneficial owner, as the case may be, to provide information concerning such Holder’s or beneficial owner’s nationality, residence, identity or connection with the Relevant
Jurisdiction, if and to the extent that due and timely compliance with such request is required by law, regulation or administrative practice of the Relevant Jurisdiction to reduce or eliminate any withholding or deduction as to which Additional
Amounts would have otherwise been payable to such Holder; 
 (2) any estate, inheritance, gift, sale, transfer, capital gains,
excise, personal property or similar tax, assessment or other governmental charge; 
 (3) any tax, duty, assessment or other
governmental charge that is payable otherwise than by withholding from payments under or with respect to the Securities; or 
 (4) any combination of taxes, duties, assessments or other governmental charges referred to in the preceding clauses (1), (2) or (3); or 
 (b) with respect to any payment of the principal of, or premium, if any, or interest on, such Security to a Holder, if the Holder is a fiduciary, partnership or person other than the sole beneficial owner of any
payment to the extent that such payment would be required to be included in the income under the laws of the Relevant Jurisdiction, for tax purposes, of a beneficiary or settlor with respect to the fiduciary, a member of that partnership or a
beneficial owner who would not have been entitled to such Additional Amounts had that beneficiary, settlor, partner or beneficial owner been the Holder thereof. 
 Whenever there is mentioned in any context the payment of principal of, and any premium or interest on, any Security, such mention shall be deemed to include payment of Additional Amounts provided for in this
Indenture to the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof. 
 Section 4.05
Company to Provide Shares. 
 (a) The Company shall, prior to issuance of any Securities hereunder, and from time to time as may be
necessary, reserve, out of its authorized but unissued share capital, a sufficient number of Ordinary Shares to be represented by ADSs to permit the conversion of all outstanding Securities into ADSs. 
 (b) All Ordinary Shares delivered to the ADS depositary for issuance of the ADSs by such depositary upon conversion of the Securities shall be newly
issued Ordinary Shares, and such Ordinary Shares and ADSs shall be duly authorized, validly issued, fully paid and nonassessable and shall be free from preemptive or similar rights and free of any lien or adverse claim as the result of any action by
the Company. 
  

 31 

 (c) The Company will endeavor promptly to comply with all foreign, United States federal and state
securities laws regulating the offer and delivery of Ordinary Shares represented by ADSs upon conversion of Securities. 
 Section 4.06
Adjustment of Conversion Rate. 
 (a) The Conversion Rate shall be adjusted from time to time by the Company as follows;
provided that to the extent that the number of Ordinary Shares represented by each ADS is changed, appropriate adjustments to the Conversion Rate adjustments made herein (which may include ignoring such provision, if appropriate) will be made
to reflect such change: 
 (1) If the Company shall pay a dividend or make a distribution to all holders of outstanding
Ordinary Shares in Ordinary Shares, the Conversion Rate in effect immediately prior to the record date for the determination of shareholders entitled to receive such dividend or other distribution shall be increased so that the same shall equal the
rate determined by the Company according to the following formula: 
  

											
	 Adjusted Conversion Rate
	 	=	  	CR	  	x	  	 OSO + DS
	  	
	 	  	  	  	OSO	  	

 Where: 
  

					
	CR	  	=	  	the Conversion Rate in effect immediately prior to such record date;
			
	OSO	  	=	  	the number of Ordinary Shares outstanding at the close of business on such record date;
			
	DS	  	=	  	the total number of Ordinary Shares constituting such dividend or other distribution

 Such adjustment shall be made successively whenever any such dividend or distribution is made and
shall become effective immediately after such record date. If any dividend or distribution of the type described in this clause is declared but not so paid or made, the Conversion Rate shall again be adjusted to the Conversion Rate that would then
be in effect if such dividend or distribution had not been declared. 
 (2) If the Company shall subdivide its outstanding
Ordinary Shares into a greater number of shares, or combine its outstanding Ordinary Shares into a smaller number of shares, the Conversion Rate in effect immediately prior to the day upon which such subdivision or combination becomes effective
shall be, in the case of a subdivision of Ordinary Shares, proportionately increased and, in the case of a combination of Ordinary Shares, proportionately reduced according to the following formula: 
  

											
	 Adjusted Conversion Rate
	 	=	  	CR	  	x	  	 OSO +/- ASN
	  	
	 	  	  	  	OSO	  	

  

 32 

					
	Where:
	CR	  	=	  	the Conversion Rate in effect immediately prior to such record date;
			
	OSO	  	=	  	the number of Ordinary Shares outstanding at the close of business on such record date;
			
	ASN	  	=	  	adjusted share number equaling the number of additional Ordinary Shares as a result of such subdivision or the total number of decreased Ordinary Shares as a result of such combination, as
applicable Such adjustment shall be made successively whenever any such subdivision or combination of the Ordinary Shares occurs and shall become effective immediately after the date upon which such subdivision or combination becomes
effective.

 (3) If the Company shall issue rights or warrants to all holders of its outstanding
Ordinary Shares entitling them (for a period expiring within 60 days after such issuance) to subscribe for or purchase Ordinary Shares (or securities convertible into Ordinary Shares) at a price per Ordinary Share (or having a conversion price per
share) less than one-tenth of the average Closing Sale Price of the ADSs for the five consecutive Trading Days immediately preceding the first public announcement of the issuance of such (as determined in accordance with clause (9) of this
Section 4.06(a)) rights or warrants, the Conversion Rate in effect immediately prior thereto shall be adjusted so that the same shall equal the rate determined according to the following formula: 
  

											
	 Adjusted Conversion Rate
	 	=	  	CR	  	x	  	 OSO + AOS
	  	
	 	  	  	  	OSO + SOS	  	

  

					
	Where:
			
	CR	  	=	  	the Conversion Rate in effect immediately prior to the date of the first public announcement of such issuance;
			
	OSO	  	=	  	the number of Ordinary Shares outstanding at the close of business on such date;
			
	AOS	  	=	  	the number of additional Ordinary Shares that such rights or warrants entitle holders thereof to subscribe for or purchaser (or into which such convertible securities are
convertible);
			
	SOS	  	=	  	the number of shares which the aggregate offering price of the total number of Ordinary Shares so offered for subscription or purchase (or the aggregate conversion price of the convertible
securities so offered for subscription or purchase, which shall be determined by multiplying the number of Ordinary Shares issuable upon conversion of such convertible securities by the conversion price per Ordinary Share pursuant to the
terms

  

 33 

 of such convertible securities) would purchase at one-tenth of the average Closing Sale Price of the ADSs
for five consecutive Trading Days immediately preceding the first public announcement of the issuance. 
 Such adjustment shall be made
successively whenever any such rights or warrants (or convertible securities) are issued, and shall become effective immediately after such date. To the extent that Ordinary Shares (or securities convertible into Ordinary Shares) are not delivered
after the expiration of such rights or warrants, the Conversion Rate shall be readjusted to the Conversion Rate that would then be in effect had the adjustments made upon the issuance of such rights or warrants been made on the basis of delivery of
only the number of Ordinary Shares (or securities convertible into Ordinary Shares) actually delivered. If such rights or warrants are not so issued, the Conversion Rate shall again be adjusted to be the Conversion Rate that would then be in effect
if the date for the determination of shareholders entitled to receive such rights or warrants had not been fixed. In determining whether any rights or warrants entitle the shareholders to subscribe for or purchase Ordinary Shares at a price less
than one-tenth of the average Closing Sale Price of the ADSs for the 5 consecutive Trading Days immediately preceding the first public announcement of the issuance and in determining the aggregate offering price of the total number of Ordinary
Shares so offered, there shall be taken into account any consideration received by the Company for such rights or warrants and any amount payable on exercise or conversion thereof, the value of such consideration, if other than cash, to be
determined by the Board of Directors. 
 (4) If the Company shall make a dividend or other distribution to all holders of its
Ordinary Shares, other than Ordinary Shares, or evidences of indebtedness or other assets of the Company, including securities (excluding (x) any issuance of rights or warrants for which an adjustment was made pursuant to
Section 4.06(a)(3), (y) dividends or distributions in connection with a reclassification, change, consolidation, merger, combination, liquidation, dissolution, winding up, sale or conveyance resulting in a change in the conversion
consideration pursuant to Section 4.10, or pursuant to any Rights Plan or (z) any dividend or distribution paid exclusively in cash for which an adjustment was made pursuant to Section 4.06(a)(6)) (the “Distributed
Securities”), then in each such case (unless the Company distributes such Distributed Securities for distribution to the Holders of Securities on such dividend or distribution date as if each Holder had converted such Security into ADSs
immediately prior to the record date with respect to such distribution) the Conversion Rate in effect immediately prior to the record date fixed for the determination of shareholders entitled to receive such dividend or distribution shall be
adjusted so that the same shall equal the rate determined according to the following formula: 
  

											
	 Adjusted Conversion Rate
	 	=	  	CR	  	x	  	 0.10 x CMP
	  	
	 	  	  	  	(0.10 x CMP) – FMV	  	

 Where: 
  

					
	CR	  	=	  	the Conversion Rate in effect immediately prior to such record date;

  

 34 

					
	CMP	  	=	  	Current Market Price per ADS on such record date;
			
	FMV	  	=	  	the fair market value (as determined in good faith by the Board of Directors, whose determination shall be conclusive evidence of such fair market value and which shall be evidenced by an
Officer’s Certificate delivered to the Trustee) on such record date of the portion of the Distributed Securities so distributed applicable to one Ordinary Share (determined on the basis of the number of Ordinary Shares outstanding at the close
of business on such record date).

 Such adjustment shall be made successively whenever any such distribution is made and shall become
effective immediately after the record date for the determination of shareholders entitled to receive such distribution. In the event that such dividend or distribution is not so paid or made, the Conversion Rate shall again be adjusted to be the
Conversion Rate that would then be in effect if such dividend or distribution had not been declared. 
 If the fair market value (as so
determined) of the portion of the Distributed Securities so distributed applicable to one Ordinary Share is equal to or greater than one-tenth of the average Closing Sale Price per ADS for the five consecutive Trading Days immediately preceding such
record date, in lieu of the foregoing adjustment, adequate provision shall be made so that each holder of a Security shall have the right to receive upon conversion the amount of Distributed Securities so distributed that such Holder would have
received had such Holder converted each Security on such record date. If the Board of Directors determines the fair market value of any distribution for purposes of this Section 4.06(a)(4) by reference to the actual or when issued trading
market for any securities, it must in doing so consider the prices in such market over the same period used in computing the average Closing Sale Price of the ADSs. 
 Notwithstanding the foregoing, if the securities distributed by the Company to all holders of its Ordinary Shares consist of Capital Stock of, or similar equity interests in, a Subsidiary or other business unit of the
Company (the “Spinoff Securities”), the Conversion Rate shall be adjusted, unless the Company makes an equivalent distribution to the Holders of the Securities, so that the same shall be equal to the rate determined by multiplying the
Conversion Rate in effect on the record date fixed for the determination of shareholders entitled to receive such distribution by a fraction, the numerator of which shall be the sum of (A) one-tenth of the average Closing Sale Price of one ADS
over the twenty consecutive Trading Day period (the “Spinoff Valuation Period”) commencing on and including the fifth Trading Day after the date on which ex-dividend trading commences for such distribution on the Nasdaq Global Select
Market or such other U.S. national or regional exchange or market on which the ADSs are then listed or quoted and (B) the average of one-tenth of the Closing Sale Prices over the Spinoff Valuation Period of the Spinoff Securities multiplied by
the number of Spinoff Securities distributed in respect of one Ordinary Share and the denominator of which shall be one-tenth of the average Closing Sale Price of one ADS over the Spinoff Valuation Period, such adjustment to become effective
immediately prior to the opening of business on the fifteenth Trading Day after the date on which ex-dividend trading commences; provided, however, that the Company may in lieu of the foregoing adjustment elect to make adequate provision so
that each Holder of Securities shall have the right to receive upon conversion thereof the amount of such Spinoff 
  

 35 

 Securities that such Holder of Securities would have received if such Securities had been converted on the record date
with respect to such distribution. 
 (5) With respect to any rights or warrants (the “Rights”) that may be issued
or distributed pursuant to any rights plan of the Company currently in effect or that the Company implements after the date of this Indenture (a “Rights Plan”), or if the Company’s current Rights Plan is still in effect, in lieu of
any adjustment required by any other provision of this Section 4.06 upon conversion of the Securities into ADSs, to the extent that such Rights Plan is in effect upon such conversion, the Holders of Securities will receive, with respect to the
ADSs (or the Ordinary Shares represented thereby) issued upon conversion, the Rights described therein (whether or not the Rights have separated from the ADSs (or the Ordinary Shares represented thereby) at the time of conversion), subject to the
limitations set forth in and in accordance with any such Rights Plan; provided that in the case of the Company’s current Rights Plan or a future Rights Plan to the extent applicable, if, at the time of conversion, however, the Rights
have separated from the ADSs (or the Ordinary Shares represented thereby) in accordance with the provisions of the Rights Plan so that Holders would not be entitled to receive any rights in respect of the ADSs issuable upon conversion of the
Securities as a result of the timing of the Conversion Date, the Conversion Rate will be adjusted as if the Company distributed to all holders of ADSs Distributed Securities constituting such rights as provided in the first paragraph of clause
(4) of this Section 4.06(a), subject to appropriate readjustment in the event of the expiration, termination, repurchase or redemption of the Rights. Any distribution of rights or warrants pursuant to a Rights Plan complying with the
requirements set forth in the immediately preceding sentence of this paragraph shall not constitute a distribution of rights or warrants pursuant to this Section 4.06(a). Other than as specified in this clause (5) of this
Section 4.06(a), there will not be any adjustment to the Conversion Rate as the result of the issuance of any Rights, the distribution of separate certificates representing such Rights, the exercise or redemption of such Rights in accordance
with any Rights Plan or the termination or invalidation of any Rights. 
 (6) If the Company shall, by dividend or otherwise,
at any time distribute (a “Triggering Distribution”) to all holders of its Ordinary Shares a payment consisting exclusively of cash (excluding any dividend or distribution in connection with the liquidation, dissolution or winding up of
the Company, whether voluntary or involuntary) the Conversion Rate shall be increased so that the same shall equal the rate determined according to the following formula: 
  

											
	 Adjusted Conversion Rate
	 	=	  	CR	  	x	  	 0.10 x CMP
	  	
	 	  	  	  	(0.10 x CMP) - FMV	  	

 Where: 
  

					
	CR	  	=	  	the Conversion Rate in effect immediately prior to the close of business on the record date for such Triggering Distribution (a “Determination Date”);

  

 36 

					
	CMP	  	=	  	Current Market Price per ADS on such Determination Date;
			
	CD	  	=	  	the amount of such cash dividend or distribution applicable to one Ordinary Share (determined on the basis of the number of Ordinary Shares outstanding at the close of business on the
Determination Date).

 Such increase is to become effective immediately prior to the opening of business on the day
following the date on which the Triggering Distribution is paid. If the amount of cash dividend or distribution applicable to one Ordinary Share is equal to or greater than one-tenth of the average Closing Sale Price per ADS for the 5 consecutive
Trading Days immediately preceding the Determination Date, in lieu of the foregoing adjustment, adequate provision shall be made so that each Holder of a Security shall have the right to receive upon conversion the amount of cash so distributed that
such Holder would have received had such Holder converted each Security on such Determination Date. In the event that such dividend or distribution is not so paid or made, the Conversion Rate shall again be adjusted to be the Conversion Rate that
would then be in effect if such divided or distribution had not been declared. 
 (7) If any tender offer made by the Company
or any of its Subsidiaries for all or any portion of their Ordinary Shares shall expire, then, if the tender offer shall require the payment to shareholders of consideration per Ordinary Share having a fair market value (determined as provided
below) that exceeds one-tenth of the Closing Sale Price per ADS on the Trading Day next succeeding the last date (the “Expiration Date”) tenders could have been made pursuant to such tender offer (as it may be amended) (the last time at
which such tenders could have been made on the Expiration Date is hereinafter sometimes called the “Expiration Time”), the Conversion Rate shall be increased so that the same shall equal the rate determined by multiplying the Conversion
Rate in effect immediately prior to the close of business on the Expiration Date by a fraction of which the numerator shall be the sum of (A) the fair market value of the aggregate consideration (the fair market value as determined in good
faith by the Board of Directors, whose determination shall be conclusive evidence of such fair market value and which shall be evidenced by an Officer’s Certificate delivered to the Trustee and the Conversion Agent) payable to shareholders
based on the acceptance (up to any maximum specified in the terms of the tender offer) of all shares validly tendered and not withdrawn as of the Expiration Time (the shares deemed so accepted, up to any such maximum, being referred to as the
“Purchased Shares”) and (B) the product of the number of Ordinary Shares outstanding (less any Purchased Shares) at the Expiration Time and one-tenth of the Closing Sale Price per ADS on the Trading Day next succeeding the Expiration
Date and the denominator of which shall be the product of the number of Ordinary Shares outstanding (including Purchased Shares but excluding any shares held in the treasury of the Company) at the Expiration Time multiplied by one-tenth of the
Closing Sale Price per ADS on the Trading Day next succeeding the Expiration Date, such increase to become effective immediately prior to the opening of business on the day following the Expiration Date. In the event that the Company is obligated to
purchase shares pursuant to any such tender offer, but the Company is permanently prevented by applicable law from effecting any or all such purchases or any or all such purchases are rescinded, the Conversion Rate shall again be adjusted to be the
Conversion Rate which would have been in effect based upon the number of shares actually purchased, if any. If 
  

 37 

 the application of this clause (7) of Section 4.06(a) to any tender offer would result in a
decrease in the Conversion Rate, no adjustment shall be made for such tender offer under this clause (7). 
 (8) For purposes
of this Section 4.06, the term “tender offer” shall mean and include both tender offers and exchange offers, all references to “purchases” of shares in tender offers (and all similar references) shall mean and include both
the purchase of shares in tender offers and the acquisition of shares pursuant to exchange offers, and all references to “tendered shares” (and all similar references) shall mean and include shares tendered in both tender offers and
exchange offers. 
 (9) For purposes of any computation of average Closing Sale Prices under this Section 4.06, if

 (A)(the “ex” date (as hereinafter defined) for any event (other than the issuance or distribution requiring such
computation) that requires an adjustment to the Conversion Rate pursuant to Section 4.06(a) (1), (2), (3), (4), (5), (6) or (7) occurs during such 5 consecutive Trading Days, the Closing Sale Price for each Trading Day prior to the
“ex” date for such other event shall be adjusted by dividing such Closing Sale Price by the same fraction by which the Conversion Rate is so required to be adjusted as a result of such other event; 
 (B) the “ex” date for any event (other than the issuance or distribution requiring such computation) that requires an adjustment
to the Conversion Rate pursuant to Section 4.06(a) (1), (2), (3), (4), (5), (6) or (7) occurs on or after the “ex” date for the issuance or distribution requiring such computation and prior to the day in question, the
Closing Sale Price for each Trading Day on and after the “ex” date for such other event shall be adjusted by dividing such Closing Sale Price by the reciprocal of the fraction by which the Conversion Rate is so required to be adjusted as a
result of such other event; and 
 (C) the “ex” date for the issuance or distribution requiring such computation is
prior to the day in question, after taking into account any adjustment required pursuant to the immediately preceding clause (A) or (B) of this Section 4.06(a)(9), the Closing Sale Price for each Trading Day on or after such
“ex” date shall be adjusted by adding thereto the amount of any cash and the fair market value (as determined in good faith by the Board of Directors in a manner consistent with any determination of such value for purposes of
Section 4.06(a)(4) or (7), whose determination shall be conclusive and set forth in a Board Resolution) of the evidences of indebtedness, shares of capital stock or assets being distributed applicable to one ADS as of the close of business on
the day before such “ex” date. 
 For purposes of any computation under Section 4.06(a)(7), if the “ex” date for any
event (other than the tender offer that is the subject of the adjustment pursuant to Section 4.06(a)(7)) that requires an adjustment to the Conversion Rate pursuant to Section 4.06(a)(1), (2), (3), (4), (5) or (6) occurs on the
date of the Expiration Time for the tender or exchange offer requiring 
  

 38 

 such computation or on the Trading Day next following the Expiration Time, the Closing Sale Price for each Trading Day on
and after the “ex” date for such other event shall be adjusted by dividing such Closing Sale Price by the reciprocal of the fraction by which the Conversion Rate is so required to be adjusted as a result of such other event. For purposes
of this Section 4.06(a)(9) the term “ex” date, when used: 
 (A) with respect to any issuance or distribution,
means the first date on which the ADSs trade regular way on the relevant exchange or in the relevant market from which the Closing Sale Price was obtained without the right to receive such issuance or distribution; 
 (B) with respect to any subdivision or combination of Ordinary Shares, means the first date on which the ADS trade regular way on such
exchange or in such market after the time at which such subdivision or combination becomes effective, and 
 (C) with respect
to any tender or exchange offer, means the first date on which the ADSs trade regular way on such exchange or in such market after the Expiration Time of such offer. 
 Notwithstanding the foregoing, whenever successive adjustments to the Conversion Rate are called for pursuant to this Section 4.06, such adjustments shall be made to the Current Market Price as may be necessary
or appropriate to effectuate the intent of this Section 4.06 and to avoid unjust or inequitable results as determined in good faith by the Board of Directors and evidenced by an Officer’s Certificate delivered to the Trustee. 

(b) In any case in which this Section 4.06 shall require that an adjustment be made following a record date, a Determination Date or Expiration
Date, as the case may be, established for the purposes specified in this Section 4.06, the Company may elect to defer (but only until five Business Days following the filing by the Company with the Trustee of the certificate described in
Section 4.08) issuing to the Holder of any Security converted after such record date, Determination Date or Expiration Date the ADSs issuable upon such conversion over and above the ADSs (or other cash, property or securities, as applicable)
issuable upon such conversion only on the basis of the Conversion Rate prior to adjustment; and, in lieu of any cash, property or securities the issuance of which is so deferred, the Company shall issue or cause its transfer agents to issue due
bills or other appropriate evidence prepared by the Company of the right to receive such cash, property or securities. If any distribution in respect of which an adjustment to the Conversion Rate is required to be made as of the record date,
Determination Date or Expiration Date therefore is not thereafter made or paid by the Company for any reason, the Conversion Rate shall be readjusted to the Conversion Rate which would then be in effect if such record date had not been fixed or such
record date, Determination Date or Expiration Date had not occurred. 
 (c) For purposes of this Section 4.06, “record date”
shall mean, with respect to any dividend, distribution or other transaction or event in which the holders of Ordinary Shares have the right to receive any cash, securities or other property or in which the Ordinary Shares (or other applicable
security) are exchanged or converted into any combination of cash, 
  

 39 

 securities or other property, the date fixed for determination of shareholders entitled to receive such cash, security or
other property (whether or not such date is fixed by the Board of Directors or by statute, contract or otherwise). 
 (d) If one or more
event occurs requiring an adjustment be made to the Conversion Rate for a particular period, adjustments to the Conversion Rate shall be determined by the Company’s Board of Directors to reflect the combined impact of such Conversion Rate
adjustment events, as set out in this Section 4.06, during such period. 
 (e) Notwithstanding the provisions set forth in
Section 4.06(a), in no event shall the total number of ADSs issuable upon conversion of a Security exceed 38.7897 per $1,000 principal amount of Securities, subject to proportional adjustments in the same manner as the Conversion Rate as
set forth in clauses (1) through (4) of Section 4.06(a). 
 Section 4.07 No Adjustment. 
 (a) No adjustment in the Conversion Rate shall be required if Holders may participate in the transactions set forth in Section 4.06 above (to the
same extent as if the Securities had been converted into ADSs immediately prior to such transactions) without converting the Securities held by such Holders. 
 (b) No adjustment in the Conversion Rate shall be required unless such adjustment would require an increase or decrease of at least 1% in the Conversion Rate as last adjusted; provided, however, that any
adjustments which would be required to be made but for this Section 4.07(b) shall be carried forward and taken into account in any subsequent adjustment. Notwithstanding the foregoing sentence, upon any conversion or at the Final Maturity Date,
all adjustments not previously made will be made on the Conversion Date or Maturity Date, as applicable. All calculations under this Article 4 shall be made to the nearest cent or to the nearest one-ten thousandth of an ADS, as the case may be, with
one half cent and 0.00005 of a share, respectively, being rounded upward. 
 (c) No adjustment in the Conversion Rate shall be required for
issuances of Ordinary Shares pursuant to a Company plan for reinvestment of dividends or interest or for a change to a par value of the Ordinary Shares. 
 (d) To the extent that the Securities become convertible into the right to receive cash, no adjustment need be made thereafter as to the cash. 
 Section 4.08 Notice of Adjustment. Whenever the Conversion Rate or conversion privilege is required to be adjusted pursuant to this
Indenture, the Company shall promptly mail to Holders a notice of the adjustment and file with the Trustee and the Conversion Agent an Officers’ Certificate briefly stating the facts requiring the adjustment and the manner of computing it.
Failure to mail such notice or any defect therein shall not affect the validity of any such adjustment. Unless and until the Trustee and the Conversion Agent shall receive an Officers’ Certificate setting forth an adjustment of the Conversion
Rate, the Trustee may assume without inquiry that the Conversion Rate has not been adjusted and that the last Conversion Rate of which it has knowledge remains in effect. 
  

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 Section 4.09 Notice of Certain Transactions. In the event that there is a dissolution or
liquidation of the Company, the Company shall mail to Holders and file with the Trustee and the Conversion Agent a notice stating the proposed effective date. The Company shall mail such notice at least 10 days before such proposed effective date.
Failure to mail such notice or any defect therein shall not affect the validity of any transaction referred to in this Section 4.09. 
 Section 4.10 Effect of Recapitalization, Reclassification, Consolidation, Merger or Sale. If any of following events occur (each, a “Business Combination”): 
 (1) any recapitalization, reclassification or change of the Ordinary Shares, other than changes resulting from a subdivision or a
combination, 
 (2) a consolidation, merger or combination involving the Company, 
 (3) a sale, conveyance or lease to another corporation of all or substantially all of the property and assets of the Company, other than
one or more of the Company’s subsidiaries, or 
 (4) any statutory share exchange, 
 in each case as a result of which holders of Ordinary Shares (including Ordinary Shares represented by ADSs) are entitled to receive shares, stock, other securities,
other property or assets (including cash or any combination thereof) with respect to or in exchange for Ordinary Shares (including Ordinary Shares represented by ADSs), the Company or the successor or purchasing corporation, as the case may be,
shall execute with the Trustee a supplemental indenture (which shall comply with the TIA as in force at the date of execution of such supplemental indenture if such supplemental indenture is then required to so comply) providing that the Holders of
the Securities then outstanding will be entitled thereafter to convert such Securities into the kind and amount of shares, stock, other securities or other property or assets (including cash or any combination thereof) which they would have owned or
been entitled to receive upon such Business Combination had such Securities been converted into Ordinary Shares (including Ordinary Shares represented by ADSs) immediately prior to such Business Combination, except that such Holders will not receive
the Make Whole Premium if such Holder does not convert its Securities “in connection with” the relevant Fundamental Change. A conversion of the Securities by a Holder will be deemed for these purposes to be “in connection with” a
Fundamental Change if the notice of such conversion is provided in compliance with Section 4.02(a) to the Conversion Agent on or subsequent to the date that is the 10th Trading Day prior to the date announced by the Company as the anticipated Fundamental Change Effective Date but before the close of business on the Business
Day immediately preceding the related Fundamental Change Repurchase Date. In the event holders of Ordinary Shares (including Ordinary Shares represented by ADSs) have the opportunity to elect the form of consideration to be received in such Business
Combination, the Company shall make adequate provision whereby the Holders of the Securities shall have a reasonable opportunity to determine the form of consideration into which all of the Securities, treated as a single class, shall be convertible
from and after the effective date of such Business Combination. Such determination shall be (i) based on the weighted average of elections made by Holders of the Securities who participate in such determination, (ii) subject to any
limitations to which all of the holders of the Ordinary Shares 
  

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 (including Ordinary Shares represented by ADSs) are subject, such as pro-rata reductions applicable to any portion of the
consideration payable in such Business Combination and (iii) conducted in such a manner as to be completed by the date which is the earliest of (a) the deadline for elections to be made by shareholders of the Company, and (b) two
Trading Days prior to the anticipated effective date of the Business Combination. The Company shall provide notice of the opportunity to determine the form of such consideration, as well as notice of the determination made by Holders of the
Securities (and the weighted average of elections), by posting such notice with DTC and providing a copy of such notice to the Trustee. In the event the effective date of the Business Combination is delayed beyond the initially anticipated effective
date, Holders of the Securities shall be given the opportunity to make subsequent similar determinations in regard to such delayed effective date. The Company may not become a party to any such transaction unless its terms are consistent with the
provisions of this Section 4.10. Such supplemental indenture shall provide for adjustments which shall be as nearly equivalent as may be practicable to the adjustments provided for in this Article 4. If, in the case of any such Business
Combination, the shares, stock or other securities and assets receivable thereupon by a holder of Ordinary Shares includes shares or stock or other securities and assets of a corporation other than the successor or purchasing corporation, as the
case may be, in such Business Combination, then such supplemental indenture shall also be executed by such other corporation and shall contain such additional provisions to protect the interests of the Holders of the Securities as the Board of
Directors shall reasonably consider necessary by reason of the foregoing, including to the extent practicable the provisions providing for the Repurchase Rights set forth in Article 3 hereof. Notwithstanding anything contained in this Section, and
for the avoidance of doubt, this Section shall not affect the right of a Holder to convert its Securities into ADSs prior to the effective date of the Business Combination. 
 Section 4.11 Trustee’s Disclaimer; Agents’ Disclaimer. 
 (a) Neither the Trustee nor any Agent shall have a duty to determine when an adjustment under this Article 4 should be made, how it should be made or what
such adjustment should be, but may accept as conclusive evidence of that fact or the correctness of any such adjustment, and shall be protected in relying upon, an Officers Certificate and/or an Opinion of Counsel, including the Officers’
Certificate with respect thereto which the Company is obligated to file with the Trustee and the Conversion Agent pursuant to Section 4.08. Neither the Trustee nor any Agent makes any representation as to the validity or value of any securities
or assets issued upon conversion of Securities, and neither the Trustee nor any Agent shall be responsible for the Company’s failure to comply with any provisions of this Article 4. 
 (b) Neither the Trustee nor any Agent shall be under any responsibility to determine the correctness of any provisions contained in any supplemental
indenture executed pursuant to Section 4.10, but may accept as conclusive evidence of the correctness thereof, and shall be fully protected in relying upon, the officers, Certificate and Opinion of Counsel, with respect thereto which the
Company is obligated to file with the Trustee and the Agents pursuant to Section 12.04. 
 Section 4.12 Voluntary Increase.
The Company from time to time may increase the Conversion Rate, to the extent permitted by law, by any amount for any period of time if the period is at least 20 days, and the Company provides 15 days prior written notice to any increase 

 

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 in the Conversion Rate to the Trustee, the Conversion Agent and Holders. The Company may also make such an increase to
the Conversion Rate as the Board of Directors determines would avoid or diminish U.S. federal income tax to holders of Ordinary Shares in connection with a dividend or distribution of shares or stock (or rights to acquire stock) or from any event
treated as such for U.S. federal income tax purposes. 
 Notwithstanding the foregoing paragraph, in no event will the total number of ADSs
issuable upon conversion of a Security exceed 38.7897 per $1,000 principal amount, subject to proportional adjustment in the same manner as the Conversion Rate as set forth in clauses (1) through (4) of Section 4.06(a) hereof.

 Section 4.13 Settlement in Cash, or a Combination of Cash and ADSs in Lieu of ADSs. 
 (a) Upon notice to the Holders no later than the second Trading Day immediately following the related Conversion Date, in lieu of delivery of all of the
ADSs otherwise issuable upon conversion of any Securities, the Company may elect to deliver cash or a combination of cash and ADSs. If the Company elects to satisfy any portion of its conversion obligation in cash, it shall specify the amount to be
satisfied in cash as a fixed dollar amount. The Company shall treat all Holders converting on the same Trading Day in the same manner. The Company shall not, however, have any obligation to settle its conversion obligations arising on different
trading days in the same manner. If the Company elects to satisfy any portion of its conversion obligation in cash, other than cash in lieu of fractional ADSs or upon the Company’s election to always settle, the Holders may retract their
conversion notice at any time during the two Trading Day period beginning on the Trading Day after the Company notified the Holders of its method of settlement (the “Conversion Retraction Period”, with the last Trading Day in the
Conversion Retraction Period the “Retraction Date”) by delivery of a written notice of retraction to the Conversion Agent. The Company will deliver any cash, ADSs, or combination thereof, to Holders in accordance with Section 4.02(a).
If a settlement is made entirely in ADSs, such settlement shall occur as soon as practicable after the third Trading Day following the Conversion Date. If a settlement is made entirely or partially in cash, such settlement, including cash, and, if
applicable, ADSs) will occur on the third Trading Day following the final Trading Day of the Cash Settlement Averaging Period. 
 (b) The
settlement amount shall be computed as follows: 
 (1) If the Company elects to satisfy the entire conversion obligation in
ADSs, the Company shall deliver to the Holder, in respect of each $1,000 principal amount of Securities surrendered for conversion, a number of ADSs equal to the Conversion Rate then in effect (provided that the Company shall deliver cash in lieu of
fractional ADSs, in accordance with Section 4.03). 
 (2) If the Company elects to satisfy the entire conversion
obligation in cash, the Company shall deliver to the Holder, in respect of each $1,000 principal amount of Securities surrendered for conversion, cash in an amount equal to the Conversion Value. 
  

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 (3) If the Company elects to satisfy the conversion obligation in a combination of cash
and ADSs, the Company shall deliver to the Holder, in respect of each $1,000 principal amount of Securities surrendered for conversion: (i) an amount in cash equal to the lesser of (A) the Conversion Value and (B) $1,000; and
(ii) if the Conversion Value is greater than $1,000, a number of ADSs per $1,000 principal amount of Securities to be converted equal to the sum of the Daily ADS Amounts for each of the Trading Days in the Cash Settlement Averaging Period. If
an event requiring an anti-dilution adjustment occurs subsequent to any Trading Day and prior to delivery of the Daily ADS Amount for such share upon settlement, such Daily ADS Amount will be appropriately adjusted. 
 ARTICLE 5 
 SUBORDINATION

 Section 5.01 Agreement of Subordination. The Company covenants and agrees, and each Holder of Securities issued hereunder
by its acceptance thereof likewise covenants and agrees, that all Securities shall be issued subject to the provisions of this Article 5; and each Person holding any Security, whether upon original issue or upon transfer, assignment or exchange
thereof, accepts and agrees to be bound by such provisions. 
 The payment of the principal of, premium, if any, and interest on, all
Securities (including, but not limited to, the Fundamental Change Purchase Price with respect to the Securities subject to purchase in accordance with Article 3 as provided in this Indenture) issued hereunder shall, to the extent and in the manner
hereinafter set forth, be subordinated and subject in right of payment to the prior payment in full in cash, or other payment satisfactory to the holders of Senior Indebtedness, of all Senior Indebtedness, whether outstanding at the date of this
Indenture or thereafter incurred. The payment of the principal of, premium, if any, and any interest amount on the Securities will rank equally in right of payment with any future Senior Subordinated Indebtedness. 
 No provision of this Article 5 shall prevent the occurrence of any default or Event of Default hereunder. 
 Section 5.02 Payments to Holders. The Company shall not make any payment with respect to the principal of, or premium, if any, or interest on
the Securities (including, but not limited to, the Fundamental Change Purchase Price with respect to the Securities subject to purchase in accordance with Article 3 as provided in this Indenture), except payments and distributions made by the
Trustee and the Paying Agent as permitted by the first or second paragraph of Section 5.05, and shall not purchase or otherwise acquire for value any Securities if: 
 (a) a default in the payment of principal, premium, interest, rent or other obligations due on any Senior Indebtedness occurs and is continuing (or, in the case of Senior Indebtedness for which there is a period of
grace, in the event of such a default that continues beyond the period of grace, if any, specified in the instrument or lease evidencing such Senior 
  

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 Indebtedness), unless and until such default shall have been cured or waived or shall have ceased to exist and notice
thereof has been given to the Trustee and the Agents ; or 
 (b) a default, other than a payment default, on Designated Senior Indebtedness
occurs and is continuing that then permits holders of such Designated Senior Indebtedness to accelerate its maturity and the Trustee and the Agents receive a notice of the default (a “Payment Blockage Notice”) from the Company. 

The Company may and shall resume payments on and distributions in respect of the Securities upon: 
 (1) in the case of a payment default of Senior Indebtedness, upon the date on which such default is cured or waived or otherwise ceases to
exist; and 
 (2) in the case of a non-payment default on Designated Senior Indebtedness referred to in clause (b) above,
the earlier of (i) 179 days after the date on which a Payment Blockage Notice is received by the Trustee and the Agents, and (ii) the date on which the non-payment default is cured or waived or otherwise ceases to exist, unless this
Article 5 otherwise prohibits the payment or distribution at the time of such payment or distribution. 
 Subject to the provisions of
Section 5.05, no subsequent Payment Blockage pursuant to this Section 5.02 may be commenced unless (i) at least 365 days shall have elapsed since the receipt by the Trustee and the Agents of the immediately prior Payment Blockage
Notice and (ii) all scheduled payments of principal, premium or interest on the Securities that have come due have been paid in full in cash. No nonpayment default that existed or was continuing on the date of delivery of any Payment Blockage
Notice to the Trustee and the Agents (unless such default was waived, cured or otherwise ceased to exist and thereafter subsequently reoccurred) shall be, or be made, the basis for a subsequent Payment Blockage Notice. 
 Upon any payment by the Company, or distribution of assets of the Company of any kind or character, whether in cash, property or securities, to creditors
upon any dissolution or winding-up or liquidation or reorganization of the Company (whether voluntary or involuntary) or in bankruptcy, insolvency, receivership or similar proceedings, all amounts due or to become due upon all Senior Indebtedness
shall first be paid in full in cash, or other payment satisfactory to the holders of Senior Indebtedness (except payments made pursuant to Article 10 from monies deposited with the Paying Agent pursuant thereto prior to commencement of proceedings
for such dissolution, winding-up, liquidation or reorganization); and upon any such dissolution or winding-up or liquidation or reorganization of the Company or bankruptcy, insolvency, receivership or other similar proceeding, any payment by the
Company, or distribution of assets of the Company of any kind or character, whether in cash, property or securities, to which the Holders of the Securities, the Trustee or any Agents would be entitled, except for the provision of this Article 5,
shall (except as aforesaid) be paid by the Company or by any receiver, trustee in bankruptcy, liquidating trustee, agent or other Person making such payment or distribution, or by the Holders of the Securities or by the Trustee or any Agents under
this Indenture if received by them or it, directly to the holders of Senior Indebtedness (pro rata to such holders on the basis of the respective amounts of Senior Indebtedness held by such holders, or as otherwise required by 
  

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 law or a court order) or their representative or representatives, or to the trustee or trustees under any indenture
pursuant to which any instruments evidencing any Senior Indebtedness may have been issued, as their respective interests may appear, to the extent necessary to pay all Senior Indebtedness in full in cash, or other payment satisfactory to the holders
of Senior Indebtedness, after giving effect to any concurrent payment or distribution to or for the holders of Senior Indebtedness, before any payment or distribution is made to the Holders of the Securities or to the Trustee or any Agent.

 In the event of the acceleration of the Securities because of an Event of Default, no payment or distribution shall be made to the
Trustee, any Agent or any Holder of Securities in respect of the principal of, premium, if any, or interest on the Securities (including, but not limited to, the Fundamental Change Purchase Price with respect to the Securities subject to purchase in
accordance with Article 3 as provided in this Indenture), except payments and distributions made by the Trustee and the Paying Agent as permitted by the first or second paragraph of Section 5.05, until all Senior Indebtedness has been paid in
full in cash or other payment satisfactory to the holders of Senior Indebtedness or such acceleration is rescinded in accordance with the terms of this Indenture. If payment of the Securities is accelerated because of an Event of Default, the
Company shall promptly notify holders of Senior Indebtedness of such acceleration. 
 In the event that, notwithstanding the foregoing
provisions, any payment or distribution of assets of the Company of any kind or character, whether in cash, property or securities (including, without limitation, by way of setoff or otherwise), prohibited by the foregoing, shall be received by the
Trustee, any Agent or the Holders of the Securities before all Senior Indebtedness is paid in full, in cash or other payment satisfactory to the holders of Senior Indebtedness, or provision is made for such payment thereof in accordance with its
terms in cash or other payment satisfactory to the holders of Senior Indebtedness, such payment or distribution shall be held in trust for the benefit of and shall be paid over or delivered to the holders of Senior Indebtedness or their
representative or representatives, or to the trustee or trustees under any indenture pursuant to which any instruments evidencing any Senior Indebtedness may have been issued, as their respective interests may appear, as calculated by the Company,
for application to the payment of all Senior Indebtedness remaining unpaid to the extent necessary to pay all Senior Indebtedness in full, in cash or other payment satisfactory to the holders of Senior Indebtedness, after giving effect to any
concurrent payment or distribution to or for the holders of such Senior Indebtedness. 
 Nothing in this Section 5.02 shall apply to
claims of, or payments to, the Trustee or any Agent under or pursuant to Section 9.07. This Section 5.02 shall be subject to the further provisions of Section 5.05. 
 For purposes of this Article 5, the words, “cash, property or securities” shall not be deemed to include shares or stock of the Company as
reorganized or readjusted, or securities of the Company or any other corporation provided for by a plan of reorganization or readjustment, the payment of which is subordinated at least to the extent provided in this Article 5 with respect to the
Securities to the payment of all Senior Indebtedness which may at the time be outstanding; provided that (i) the Senior Indebtedness is assumed by the new corporation, if any, resulting from any reorganization or readjustment, and
(ii) the rights of the holders of Senior Indebtedness 
  

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 (other than leases which are not assumed by the Company or the new corporation, as the case may be) are not, without the
consent of such Holders, altered by such reorganization or readjustment. The consolidation of the Company with, or the merger of the Company into, another corporation or the liquidation or dissolution of the Company following the conveyance or
transfer of its property as an entirety, or substantially as an entirety, to another corporation upon the terms and conditions provided for in Article 7 shall not be deemed a dissolution, winding-up, liquidation or reorganization for the purposes of
this Section 5.02 if such other corporation shall, as a part of such consolidation, merger, conveyance or transfer, comply with the conditions stated in Article 7. 
 Section 5.03 Subrogation of Securities. Subject to the payment in full, in cash or other payment satisfactory to the holders of Senior Indebtedness, of all Senior Indebtedness, the rights of the Holders of
the Securities shall be subrogated to the extent of the payments or distributions made to the holders of such Senior Indebtedness pursuant to the provisions of this Article 5 (equally and ratably with the holders of all indebtedness of the Company
which by its express terms is subordinated to other indebtedness of the Company to substantially the same extent as the Securities are subordinated and is entitled to like rights of subrogation) to the rights of the holders of Senior Indebtedness to
receive payments or distributions of cash, property or securities of the Company applicable to the Senior Indebtedness until the principal, premium, if any, and interest on the Securities shall be paid in full in cash or other payment satisfactory
to the holders of Senior Indebtedness. For the purposes of such subrogation, no payments or distributions to the holders of the Senior Indebtedness of any cash, property or securities to which the Holders of the Securities, the Trustee or any Agent
would be entitled except for the provisions of this Article 5, and no payment pursuant to the provisions of this Article 5, to or for the benefit of the holders of Senior Indebtedness by Holders of the Securities or the Trustee, shall, as between
the Company, its creditors other than holders of Senior Indebtedness, and the Holders of the Securities, be deemed to be a payment by the Company to or on account of the Senior Indebtedness. No payments or distributions of cash, property or
securities to or for the benefit of the Holders of the Securities, pursuant to the subrogation provisions of this Article 5, which would otherwise have been paid to the holders of Senior Indebtedness shall be deemed to be a payment by the Company to
or for the account of the Securities. It is understood that the provisions of this Article 5 are and are intended solely for the purposes of defining the relative rights of the Holders of the Securities, on the one hand, and the holders of the
Senior Indebtedness, on the other hand. 
 Nothing contained in this Article 5 or elsewhere in this Indenture or in the Securities is
intended to or shall impair, as among the Company, its creditors other than the holders of Senior Indebtedness, and the Holders of the Securities, the obligation of the Company, which is absolute and unconditional, to pay to the Holders of the
Securities the principal of, and premium, if any, and interest on the Securities as and when the same shall become due and payable in accordance with their terms, or is intended to or shall affect the relative rights of the Holders of the Securities
and creditors of the Company other than the holders of the Senior Indebtedness, nor shall anything herein or therein prevent the Trustee, any Agent or the Holder of any Security from exercising all remedies otherwise permitted by applicable law upon
default under this Indenture, subject to the rights, if any, under this Article 5 of the holders of Senior Indebtedness in respect of cash, property or securities of the Company received upon the exercise of any such remedy. 
  

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 Upon any payment or distribution of assets of the Company referred to in this Article 5, the Trustee and
the Agents, subject to the provisions of Section 9.01, and the Holders of the Securities shall be entitled to rely upon any order or decree made by any court of competent jurisdiction in which such bankruptcy, dissolution, winding-up,
liquidation or reorganization proceedings are pending, or a certificate of the receiver, trustee in bankruptcy, liquidating trustee, agent or other person making such payment or distribution, delivered to the Trustee, any Agent or to the Holders of
the Securities, for the purpose of ascertaining the persons entitled to participate in such distribution, the holders of the Senior Indebtedness and other indebtedness of the Company, the amount thereof or payable thereon and all other facts
pertinent thereto or to this Article 5. 
 Section 5.04 Authorization to Effect Subordination. Each Holder of a Security by the
Holder’s acceptance thereof authorizes and directs the Trustee or any Agent on the Holder’s behalf to take such action as may be necessary or appropriate to effectuate the subordination as provided in this Article 5 and appoints the
Trustee to act as the Holder’s attorney-in-fact for any and all such purposes. If the Trustee does not file a proper proof of claim or proof of debt in the form required in any proceeding referred to in Section 5.03 hereof at least 30 days
before the expiration of the time to file such claim, the holders of any Senior Indebtedness or their representatives are hereby authorized to file an appropriate claim for and on behalf of the Holders of the Securities. 
 Section 5.05 Notice to Trustee. The Company shall give prompt written notice in the form of an Officers’ Certificate to a Trust Officer
of the Trustee and to any Paying Agent of (a) all Senior Indebtedness incurred by the Company, including the names of representatives of such holders (if actually known by the Company) of holders of Senior Indebtedness and (b) any fact
known to the Company which would prohibit the making of any payment of monies to or by the Trustee or any Paying Agent in respect of the Securities pursuant to the provisions of this Article 5. Notwithstanding the provisions of this Article 5 or any
other provision of this Indenture, the Trustee and the Agents shall not be charged with knowledge of the existence of any facts which would prohibit the making of any payment of monies to or by the Trustee and the Agents in respect of the Securities
pursuant to the provisions of this Article 5, unless and until a Trust Officer of the Trustee and the Agents shall have received written notice thereof at the Corporate Trust Office or at the address for notice set forth in Section 12.02
hereof, respectively, from the Company (in the form of an Officers’ Certificate); and before the receipt of any such written notice, the Trustee and the Agents, subject to the provisions of Section 9.01, shall be entitled in all respects
to assume that no such facts exist; provided that if on a date not fewer than one Business Day prior to the date upon which by the terms hereof any such monies may become payable for any purpose (including, without limitation, the payment of
the principal of, or premium, if any, or interest on any Security) the Trustee and the Agents shall not have received, with respect to such monies, the notice provided for in this Section 5.05, then, anything herein contained to the contrary
notwithstanding, the Trustee and the Agents shall have full power and authority to receive such monies and to apply the same to the purpose for which they were received, and shall not be affected by any notice to the contrary which may be received
by it on or after such prior date. Notwithstanding anything in this Article 5 to the contrary, nothing shall prevent any payment by the Trustee and the Agents to the Holders of monies deposited with it pursuant to Article 10, and any such payment
shall not be subject to the provisions of Article 5. 
  

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 In the event that the Trustee or any Agent determines in good faith that further evidence is required
with respect to the right of any person as a holder of Senior Indebtedness to participate in any payment or distribution pursuant to this Article 5, the Trustee or any Agent may request such Person to furnish evidence to the reasonable satisfaction
of the Trustee or such Agent as to the amount of Senior Indebtedness held by such Person, the extent to which such Person is entitled to participate in such payment or distribution and any other facts pertinent to the rights of such Person under
this Article 5, and if such evidence is not furnished the Trustee or any Agent may defer any payment to such Person pending judicial determination as to the right of such Person to receive such payment. 
 Section 5.06 Trustee’s Relation to Senior Indebtedness. The Trustee and the Agents, respectively, in their individual capacities shall
be entitled to all the rights set forth in this Article 5 in respect of any Senior Indebtedness at any time held by it, to the same extent as any other holder of Senior Indebtedness, and nothing in Section 9.11 or elsewhere in this Indenture
shall deprive the Trustee or any such Agents of any of its rights as such holder. 
 With respect to the holders of Senior Indebtedness, the
Trustee and the Agents undertake to perform or to observe only such of its covenants and obligations as are specifically set forth in this Article 5, and no implied covenants or obligations with respect to the holders of Senior Indebtedness shall be
read into this Indenture against the Trustee or the Agents. Neither the Trustee nor any Agent shall be deemed to owe any fiduciary duty to the holders of Senior Indebtedness and neither the Trustee nor any Agent shall be liable to any holder of
Senior Indebtedness if it shall pay over or deliver to Holders of Securities, the Company or any other person money or assets to which any holder of Senior Indebtedness shall be entitled by virtue of this Article 5 or otherwise. 
 Section 5.07 No Impairment of Subordination. No right of any present or future holder of any Senior Indebtedness to enforce subordination as
herein provided shall at any time in any way be prejudiced or impaired by any act or failure to act on the part of the Company or by any act or failure to act, in good faith, by any such holder, or by any noncompliance by the Company with the terms,
provisions and covenants of this Indenture, regardless of any knowledge thereof which any such holder may have or otherwise be charged with. 
 Section 5.08 Certain Conversions Deemed Payment. For the purposes of this Article 5 only, (1) the issuance and delivery of junior securities upon conversion of Securities in accordance with Article 4 shall not be deemed to
constitute a payment or distribution on account of the principal of (or premium, if any) or interest on Securities or on account of the purchase or other acquisition of Securities, and (2) the payment, issuance or delivery of cash (except in
satisfaction of fractional shares pursuant to Section 4.03), property or securities (other than junior securities) upon conversion of a Security shall be deemed to constitute payment on account of the principal of such Security. For the
purposes of this Section 5.08, the term “junior securities” means (a) shares of any class of the Company, or (b) securities of the Company which are subordinated in right of payment to all Senior Indebtedness which may be
outstanding at the time of issuance or delivery of such securities to substantially the same extent as, or to a greater extent than, the Securities are so subordinated as provided in this Article. Nothing contained in this Article 5 or elsewhere in
this Indenture or in the Securities is intended to or shall impair, as among the Company, its creditors other than holders of Senior Indebtedness and the Holders, the right, which is absolute and unconditional, of the Holder of any Security to
convert such Security in accordance with Article 4. 
  

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 Section 5.09 Article Applicable to Paying Agents. If at any time any Paying Agent other than
the Trustee shall have been appointed by the Company and be then acting hereunder, the term “Trustee” as used in this Article shall (unless the context otherwise requires) be construed as extending to and including such Paying Agent within
its meaning as fully for all intents and purposes as if such Paying Agent were named in this Article in addition to or in place of the Trustee; provided, however, that the first paragraph of Section 5.05 shall not apply to the Company or
any Affiliate of the Company if it or such Affiliate acts as Paying Agent. 
 Section 5.10 Senior Indebtedness Entitled to Rely.
The holders of Senior Indebtedness (including, without limitation, Designated Senior Indebtedness) shall have the right to rely upon this Article 5, and no amendment or modification of the provisions contained herein shall diminish the rights of
such holders unless such holders shall have agreed in writing thereto. 
 ARTICLE 6 
 COVENANTS 
 Section 6.01
Payment of Securities. 
 (a) The Company shall promptly make all payments in respect of the Securities on the dates and in the manner
provided in the Securities and this Indenture. A payment of principal or interest or Additional Interest, if any, shall be considered paid on the date it is due if the Paying Agent (other than the Company) holds by 12:00 p.m. (noon), New York City
time, on that date money, deposited by or on behalf of the Company, deposited for and sufficient to make the payment. Subject to Section 4.02, accrued and unpaid interest on any Security that is payable, and is punctually paid or duly provided
for, on any Interest Payment Date shall be paid to the Person in whose name that Security is registered at the close of business on the Regular Record Date for such interest at the office or agency of the Company maintained for such purpose.
Principal, Fundamental Change Purchase Price, and interest and Additional Interest, if any, in each case if payable, shall be considered paid on the applicable date due if on such date (or, in the case of Fundamental Change Purchase Price, on the
Business Day following the applicable Fundamental Change Purchase Date) the Trustee or the Paying Agent holds, in accordance with this Indenture, money sufficient to pay all such amounts then due. The Company shall, to the fullest extent permitted
by law, pay interest in immediately available funds on overdue principal amount and interest at the annual rate borne by the Securities compounded semiannually, which interest shall accrue from the date such overdue amount was originally due to the
date payment of such amount, including interest thereon, has been made or duly provided for. All such interest shall be payable on demand. 
 (b) Payment of the principal of and interest, if any, on the Securities shall be made at the office or agency of the Company maintained for that purpose (which shall initially be at the address set forth in Section 12.02) in such coin
or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by check 
  

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 mailed to the address of the Person entitled thereto as such address appears in the records of the Registrar; provided
further that a Holder with an aggregate principal amount in excess of $2,000,000 will be paid by wire transfer in immediately available funds at the election of such Holder if such Holder has provided wire transfer instructions to the Trustee or
the Paying Agent at least 10 Business Days prior to the payment date. Any wire transfer instructions received by the Trustee or the Paying Agent will remain in effect until revoked by the Holder. Notwithstanding the foregoing, so long as this
Security is registered in the name of a Depositary or its nominee, all payments hereon shall be made by wire transfer of immediately available funds to the account of the Depositary or its nominee. 
 (c) All amounts to be paid by the Paying Agent hereunder shall be deposited with the Paying Agent by 12:00 p.m. (noon) New York City time one Business
Day prior to the due date for such payment. The Paying Agent shall have no obligation to make payments required hereunder until it has on deposit an amount sufficient to fund the full amount of any such payment. 
 Section 6.02 SEC and Other Reports. 
 (a) The Company shall file all reports and other information and documents which it is required to file with the SEC pursuant to Section 13 or 15(d) of the Exchange Act, and within 15 days after it files them with the SEC, the Company
shall file copies of all such reports, information and other documents with the Trustee; provided that any such reports, information and documents filed with the SEC pursuant to its Electronic Data Gathering, Analysis and Retrieval (or EDGAR)
system shall be deemed to be filed with the Trustee. The Company also shall comply with the provisions of TIA Section 314(a). 
 (b)
Delivery of such reports, information and documents to the Trustee is for informational purposes only and the Trustee’s receipt of such shall not constitute constructive notice of any information contained therein or determinable from
information contained therein, including the Company’s compliance with any of its covenants hereunder (as to which the Trustee and Agents are entitled to rely exclusively on Officers’ Certificates). 
 Section 6.03 Compliance Certificates. The Company shall deliver to the Trustee or any Agent, within 180 days after the end of each fiscal
year of the Company (beginning with the fiscal year ending March 31, 2007), an Officers’ Certificate as to the signer’s knowledge of the Company’s compliance with all conditions and covenants on its part contained in this
Indenture and stating whether or not the signer knows of any Default or Event of Default. If such signer knows of such a Default or Event of Default, the Officers’ Certificate shall describe the Default or Event of Default and the efforts to
remedy the same. For the purposes of this Section 6.03, compliance shall be determined without regard to any grace period or requirement of notice provided pursuant to the terms of this Indenture. 
 Section 6.04 Further Instruments and Acts. Upon request of the Trustee or any Agent, the Company will execute and deliver such further
instruments and do such further acts as may be reasonably necessary or proper to carry out more effectively the purposes of this Indenture. 
  

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 Section 6.05 Maintenance of Corporate Existence. Subject to Article 7, the Company will do or
cause to be done all things necessary to preserve and keep in full force and effect its corporate existence. 
 Section 6.06 Rule
144A Information Requirement. Within the period prior to the expiration of the holding period applicable to sales thereof under Rule 144(k) under the Securities Act (or any successor provision), the Company covenants and agrees that it shall,
during any period in which it is not subject to Section 13 or 15(d) under the Exchange Act, upon the request of any Holder or beneficial holder of the Securities make available to such Holder or beneficial holder of Securities or any ADSs
issued upon conversion thereof which continue to be Restricted Securities in connection with any sale thereof and any prospective purchaser of Securities or such ADSs designated by such Holder or beneficial holder, the information required pursuant
to Rule 144A(d)(4) under the Securities Act and it will take such further action as any Holder or beneficial holder of such Securities or such ADSs may reasonably request, all to the extent required from time to time to enable such Holder or
beneficial holder to sell its Securities or ADSs without registration under the Securities Act within the limitation of the exemption provided by Rule 144A, as such Rule may be amended from time to time. Whether a person is a beneficial holder shall
be determined by the Company. 
 Section 6.07 Stay, Extension and Usury Laws. The Company covenants (to the extent that it may
lawfully do so) that it shall not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law or other law which would prohibit or forgive the Company from paying all or any
portion of the principal of or accrued but unpaid interest or Additional Interest, if any, on the Securities as contemplated herein, wherever enacted, now or at any time hereafter in force, or which may affect the covenants or the performance of
this Indenture, and the Company (to the extent it may lawfully do so) hereby expressly waives all benefit or advantage of any such law and covenants that it will not, by resort to any such law, hinder, delay or impede the execution of any power
herein granted to the Trustee or any Agent, but will suffer and permit the execution of every such power as though no such law had been enacted. 
 Section 6.08 Payment of Additional Interest. If Additional Interest is payable by the Company pursuant to the Registration Rights Agreement, the Company shall deliver to the Trustee and the Paying Agent an Officers’
Certificate to that effect stating (i) the amount of such Additional Interest that is payable, (ii) the reason why such Additional Interest is payable and (iii) the date on which such Additional Interest is payable. Unless and until a
Trust Officer of the Trustee and the Paying Agent receive such a certificate, the Trustee and the Paying Agent may assume without inquiry that no such Additional Interest is payable. If the Company has paid Additional Interest directly to the
Persons entitled to such Additional Interest, the Company shall deliver to the Trustee and the Paying Agent a certificate setting forth the particulars of such payment. The Trustee may conclusively rely on the correctness of the Additional Interest
calculations provided by the Company without investigation. 
 Section 6.09 Maintenance of Office or Agency. The Company will
maintain an office or agency of the Trustee, Transfer Agent, Registrar, Conversion Agent and Paying Agent where securities may be presented or surrendered for payment, where Securities may be surrendered for registration of transfer or purchase,
where Securities may be surrendered for conversion and 
  

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 where notices and demands to or upon the company in respect of the Securities and this Indenture may be served. The
address for the Initial Agent set forth in Section 12.02 shall initially be one such office or agency for all of the aforesaid purposes. The Company shall give prompt written notice to the Trustee and all other Agents of the location, and of
any change in the location, of any such office or agency (other than a change in the location of the office of the Trustee). If at any time the Company shall fail to maintain any such required office or agency or shall fail to furnish the Trustee
with the address thereof, such presentations, surrenders, notices and demands may be made or served at the address of the Trustee set forth in Section 12.02. 
 The Company may also from time to time designate one or more other offices or agencies where the Securities may be presented or surrendered for any or all such purposes and may from time to time rescind such
designations; provided, however, that no such designation or rescission shall in any manner relieve the Company of its obligation to maintain an office or agency. 
 ARTICLE 7 
 CONSOLIDATION; MERGER; CONVEYANCE; TRANSFER OR LEASE 
 Section 7.01 Company May Consolidate, etc. only on Certain Terms. The Company may not consolidate with or merge into any Person (unless the
Company is the surviving corporation) or convey, transfer or lease the property and assets, substantially as an entity, of the Company to another Person, other than to one or more of the Company’s wholly-owned subsidiaries, unless: 

(1) the Person (if other than the Company) formed by such consolidation or into which the Company is merged, or the Person which
acquires by conveyance, transfer or lease all or substantially all of the properties and assets of the Company, shall (i) be a corporation, limited liability company, partnership, trust or other business entity organized and existing under the
laws of the Cayman Islands, the British Virgin Islands, Bermuda, Hong Kong, or the United States of America, or any State thereof or the District of Columbia and (ii) such Person (if other than the Company) expressly assumes, by an indenture
supplemental hereto, executed and delivered to the Trustee, in form satisfactory to the Trustee, the obligations of the Company under the Securities and this Indenture and the performance or observance of every covenant and provision of this
Indenture and the Securities required on the part of the Company to be performed or observed and the conversion rights shall be provided for in accordance with Article 4, by supplemental indenture satisfactory in form to the Trustee, executed and
delivered to the Trustee, by the Person (if other than the Company) formed by such consolidation or into which the Company shall have been merged or by the Person which shall have acquired the Company’s assets; 
 (2) after giving effect to such transaction, no Event of Default, and no event which, after notice or lapse of time or both, would become
an Event of Default, shall have occurred and be continuing; and 
 (3) if the Company will not be the resulting or surviving
corporation, the Company shall have, at or prior to the effective date of such consolidation, merger or 
  

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 transfer, delivered to the Trustee an Officers’ Certificate and an Opinion of Counsel, each stating
that such consolidation, merger or transfer complies with this Section 7.01 and, if a supplemental indenture is required in connection with such transaction, such supplemental indenture complies with this Article, and that all conditions
precedent herein provided for relating to such transaction have been complied with. 
 Section 7.02 Successor Substituted. Upon
any consolidation of the Company with, or merger of the Company into, any other Person or any conveyance, transfer or lease substantially as an entity, of the properties and assets of the Company and its Subsidiaries, taken as a whole, in accordance
with Section 7.01, the successor Person formed by such consolidation or into which the Company is merged or to which such conveyance, transfer or lease is made shall succeed to, and be substituted for, and may exercise every right and power of,
the Company under this Indenture with the same effect as if such successor Person had been named as the Company herein, and thereafter, except in the case of a lease, and except for obligations the predecessor Person may have under a supplemental
indenture, the predecessor Person shall be relieved of all obligations and covenants under this Indenture and the Securities. 
 ARTICLE 8

 DEFAULT AND REMEDIES 
 Section 8.01 Events of Default. 
 (a) An “Event of Default” shall occur if: 
 (1) the Company shall fail to pay when due the Principal or any Fundamental Change Purchase Price of any Security, including any
Make-Whole Premium, when the same becomes due and payable whether at the Final Maturity Date, upon repurchase, acceleration or otherwise, whether or not such payment is prohibited by Article 5 of this Indenture; or 
 (2) the Company shall fail to pay an installment of interest or Additional Interest, if any, on any of the Securities, which failure
continues for 30 days after the date when due, whether or not such payment is prohibited by Article 5 of this Indenture; or 
 (3) the Company shall fail to deliver when due all ADSs and any cash (or any combination thereof), deliverable upon conversion of the Securities, which failure continues for 15 days after such delivery date, whether or not such delivery is
prohibited by Article 5 of this Indenture; or 
 (4) the Company shall fail to perform or observe (or obtain a waiver
with respect to) any other term, covenant or agreement contained in the Securities or this Indenture for a period of 60 days after receipt by the Company of a Notice of Default specifying such failure; or 
 (5) the Company shall fail to pay any principal by the end of any applicable grace period or resulting in acceleration of other
Indebtedness of the Company 
  

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 for borrowed money where the aggregate principal amount with respect to which the default or acceleration
has occurred exceeds $15 million and such acceleration has not been rescinded or annulled or such Indebtedness repaid within a period of 30 days after receipt of a Notice of Default (as defined below), provided that if any such default
is cured, waived, rescinded or annulled, then the Event of Default by reason thereof would be deemed not to have occurred; or 
 (6) the Company pursuant to or within the meaning of any Bankruptcy Law: 
 (A) commences as a debtor a voluntary
case or proceeding; or 
 (B) consents to the entry of an order for relief against it in an involuntary case or proceeding or
the commencement of any case against it; 
 (C) consents to the appointment of a Receiver of it or for all or substantially
all of its property; or 
 (D) makes a general assignment for the benefit of its creditors; 
 (E) files a petition in bankruptcy or answer or consent seeking reorganization or relief; or 
 (F) consents to the filing of such a petition or the appointment of or taking possession by a Receiver; or 
 (7) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 
 (A) grants relief against the Company in an involuntary case or proceeding or adjudicates the Company insolvent or bankrupt; 

(B) appoints a Receiver of the Company or for all or substantially all of the property of the Company; or 
 (C) orders the winding up or liquidation of the Company; 
 and in each case the order or decree remains unstayed and in effect for 60 consecutive days. 
 The term
“Bankruptcy Law” means Title 11 of the United States Code (or any successor thereto) or any similar foreign, federal or state law for the relief of debtors. The term “Receiver” means any receiver, trustee, assignee, liquidator,
sequestrator or similar official under any Bankruptcy Law. 
 (b) Notwithstanding Section 8.01(a), no Event of Default under clauses
(4) or (5) of Section 8.01(a) shall occur until the Trustee notifies the Company in writing upon the written direction of the Holders of at least 25% in aggregate principal amount of the Securities 
  

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 then outstanding, or the Holders of at least 25% in aggregate principal amount of the Securities then outstanding notify
the Company and the Trustee in writing, of the Default (a “Notice of Default”), and the Company does not cure the Default within the time specified in clause (4) or (5) of Section 8.01(a), as applicable, after receipt of
such notice. A notice given pursuant to this Section 8.01 shall be given by registered or certified mail, must specify the Default, demand that it be remedied and state that the notice is a Notice of Default. When any Default under this
Section 8.01 is cured, it ceases. 
 (c) The Company will deliver to the Trustee, within five Business Days after becoming aware of the
occurrence of a Default or Event of Default, written notice thereof. 
 The Trustee shall not be charged with knowledge of any Event of
Default unless written notice thereof shall have been given to a Trust Officer with responsibility for this Indenture at the Corporate Trust Office of the Trustee by the Company, a Paying Agent, any Holder or any agent of any Holder or unless a
Trust Officer with responsibility for this Indenture acquires actual knowledge of such Event of Default in the course of performing other duties pursuant to this Indenture. 
 Section 8.02 Acceleration. If an Event of Default (other than an Event of Default specified in clause (6) or (7) of
Section 8.01(a)) occurs and is continuing with respect to the Company, the Trustee may, by notice to the Company, and shall upon the written direction of the Holders of at least 25% in aggregate principal amount of the Securities then
outstanding, declare the principal amount and accrued and unpaid interest, if any, and accrued and unpaid Additional Interest, if any, through the date of declaration on all the Securities to be immediately due and payable. Upon such a declaration,
such principal amount and such accrued and unpaid interest, if any, and such accrued and unpaid Additional Interest, if any, shall be due and payable immediately. If an Event of Default specified in Section 8.01(a)(6) or (7) occurs in
respect of the Company and is continuing, the principal amount and accrued but unpaid interest, if any, and accrued and unpaid Additional Interest, if any, on all the Securities shall become and be immediately due and payable without any declaration
or other act on the part of the Trustee or any Holders of Securities. The Holders of a majority in aggregate principal amount of the Securities then outstanding by notice to the Trustee may rescind an acceleration and its consequences if
(a) all existing Events of Default, other than the nonpayment of the principal of the Securities which have become due solely by such declaration of acceleration, have been cured or waived; (b) to the extent the payment of such interest is
lawful, interest (calculated at the rate per annum borne by the Securities) on overdue installments of interest and overdue principal, which has become due otherwise than by such declaration of acceleration, has been paid; (c) the rescission
would not conflict with any judgment or decree of a court of competent jurisdiction; and (d) all payments due to the Trustee, the Agents and any predecessor Trustee or Agent under Section 9.07 have been made. No such rescission shall
affect any subsequent Default or impair any right consequent thereto. 
 Section 8.03 Other Remedies. 
 (a) If an Event of Default occurs and is continuing, the Trustee may, but shall not be obligated to, pursue any available remedy by proceeding at law or
in equity to collect payment of the principal amount and accrued and unpaid interest, if any, and accrued and unpaid Additional Interest, if any, on the Securities or to enforce the performance of any provision of the Securities or this Indenture.

  

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 (b) The Trustee may maintain a proceeding even if it does not possess any of the Securities or does not
produce any of them in the proceeding. A delay or omission by the Trustee or any Holder in exercising any right or remedy accruing upon an Event of Default shall not impair the right or remedy or constitute a waiver of or acquiescence in the Event
of Default. No remedy is exclusive of any other remedy. All available remedies are cumulative to the extent permitted by applicable law. 
 Section 8.04 Waiver of Defaults and Events of Default. Subject to Sections 8.02, 8.07 and 11.02, the Holders of a majority in aggregate principal amount of the Securities then outstanding by notice to the Trustee may waive an
existing Default or Event of Default and its consequences, except an uncured Default or Event of Default in the payment of the principal of, premium, if any, or any accrued but unpaid interest on any Security, an uncured failure by the Company to
convert any Securities into ADSs or cash, or a combination thereof or any Default or Event of Default in respect of any provision of this Indenture or the Securities which, under Section 11.02, cannot be modified or amended without the consent
of the Holder of each Security affected. When a Default or Event of Default is waived, it is cured and ceases to exist. 
 Section 8.05
Control by Majority. The Holders of a majority in aggregate principal amount of the Securities then outstanding may direct the time method and place of conducting any proceeding for any remedy available to the Trustee or exercising any trust
or power conferred on it. However, the Trustee may refuse to follow, without liability, any direction that conflicts with law or this Indenture, that the Trustee determines may be unduly prejudicial to the rights of another Holder or the Trustee, or
that may involve the Trustee in personal liability unless the Trustee is offered security or indemnity satisfactory to it; provided, however, that the Trustee may take any other action deemed proper by the Trustee which is not inconsistent
with such direction. 
 Section 8.06 Limitations on Suits. 
 (a) A Holder may not pursue any remedy with respect to this Indenture or the Securities (except actions for payment of overdue principal, premium, if any,
or interest or for the conversion of the Securities pursuant to Article 4) unless: 
 (1) the Holder gives to the Trustee
written notice of a continuing Event of Default; 
 (2) the Holders of at least 25% in aggregate principal amount of the then
outstanding Securities make a written request to the Trustee to pursue the remedy; 
 (3) such Holder or Holders offer to the
Trustee security or indemnity acceptable to the Trustee against any loss, liability or expense; 
 (4) the Trustee does not
comply with the request within 60 days after receipt of the request and the offer of security or indemnity; and 
  

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 (5) no direction inconsistent with such written request has been given to the Trustee
during such 60-day period by the Holders of a majority in aggregate principal amount of the Securities then outstanding. 
 (b) No Holder of
a Security shall have any right under any provision of this Indenture or the Securities to affect, disturb, or prejudice the rights of another Holder of a Security or to obtain a preference or priority over another Holder of a Security. 

Section 8.07 Rights of Holders to Receive Payment and to Convert. Notwithstanding any other provision of this Indenture, the right of any
Holder of a Security to receive payment of the principal amount, Fundamental Change Purchase Price, or Make-Whole Premium and interest, if any or Additional Interest, if any, in respect of the Securities held by such Holder, on or after the
respective due dates expressed in the Securities and this Indenture, (whether upon repurchase or otherwise), and to convert such Security in accordance with Article 4, and to bring suit for the enforcement of any such payment on or after such
respective due dates or for the right to convert in accordance with Article 4, is, subject to compliance with the provisions of Section 8.06, absolute and unconditional and shall not be impaired or affected without the consent of the Holder.

 Section 8.08 Collection Suit by Trustee. If an Event of Default described in clause (1) or (2) of
Section 8.01(a) occurs and is continuing, the Trustee may recover judgment in its own name and as trustee of an express trust against the Company or another obligor on the Securities for the whole amount owing with respect to the Securities and
such further amount as shall be sufficient to cover the costs and expenses of collection, including the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel. 
 Section 8.09 Trustee may File Proofs of Claim. The Trustee may file such proofs of claim and other papers or documents as may be necessary or
advisable in order to have the claims of the Trustee (including any claim for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel) and the Holders allowed in any judicial proceedings relative to
the Company (or any other obligor on the Securities), its creditors or its property and shall be entitled and empowered to collect and receive any money or other property payable or deliverable on any such claims and to distribute the same, and any
Receiver in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee and, in the event that the Trustee shall consent to the making of such payments directly to the Holders, to pay to the Trustee any
amount due to it for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 9.07, and to the extent that such payment of the reasonable
compensation, expenses, disbursements and advances in any such proceedings shall be denied for any reason, payment of the same shall be secured by a lien on, and shall be paid out of, any and all distributions, dividends, money, securities and other
property which the Holders may be entitled to receive in such proceedings, whether in liquidation or under any plan of reorganization or arrangement or otherwise. Nothing herein contained shall be deemed to authorize the Trustee to authorize or
consent to, or, on behalf of any Holder, to authorize, accept or adopt any plan of reorganization, arrangement, adjustment or composition affecting the Securities or the rights of any Holder thereof, or to authorize the Trustee to vote in respect of
the claim of any Holder in any such proceeding. 
  

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 Section 8.10 Priorities. 
 (a) If the Trustee collects any money pursuant to this Article 8, it shall pay out the money in the following order: 
 (1) First, to the Trustee and the Agents for amounts due under Section 9.07; 
 (2) Second, to the Holders of Senior Indebtedness to the extent required by Article 5; 
 (3) Third, to Holders for amounts due and unpaid on the Securities for the principal amount, interest, and Additional Interest, as
applicable, ratably, without preference or priority of any kind, according to such respective amounts due and payable on the Holders’ Securities; 
 (4) Fourth, to such other Person or Persons, if any, to the extent entitled thereto; and 
 (5) Fifth, the balance, if any, to the Company. 
 (b) The Trustee may fix a record date and payment date for any payment to Holders
pursuant to this Section 8.10. 
 Section 8.11 Undertaking for Costs. In any suit for the enforcement of any right or remedy
under this Indenture or in any suit against the Trustee for any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in the suit of an undertaking to pay the costs of the suit, and the
court in its discretion may assess reasonable costs, including reasonable attorneys’ fees and expenses (whether incurred before trial, at trial, on appeal or in any bankruptcy or arbitration or other administrative proceeding), against any
party litigant in the suit, having due regard to the merits and good faith of the claims or defenses made by the party litigant. This Section 8.11 does not apply to a suit made by the Trustee, a suit by a Holder pursuant to Section 8.07,
or a suit by Holders of more than 10% in aggregate principal amount of the Securities then outstanding. This Section 8.11 shall be in lieu of Section 315(e) of the TIA and such Section 315(e) is hereby expressly excluded from this
Indenture, as permitted by the TIA. 
 ARTICLE 9 
 TRUSTEE AND AGENTS 
 Section 9.01 Obligations of Trustee and Agents. 
 (a) If an Event of Default of which a Responsible Officer of the Trustee shall have actual knowledge has occurred and is continuing, the Trustee may (and
shall upon the written direction of the Holders of at least 25% in aggregate principal amount of the Securities then outstanding and being furnished with indemnity acceptable to it) exercise such of the rights and powers vested in it by this
Indenture. If an Event of Default of which a Responsible Officer 
  

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 of the Trustee shall have actual knowledge has occurred and is continuing, the Trustee shall use the same degree of care
and skill in its exercise as a prudent person would exercise or use under the circumstances in the conduct of his or her own affairs. 
 (b)
The Trustee, except during the continuance of an Event of Default of which a Responsible Officer of the Trustee shall have actual knowledge, and the Agents need perform only those duties as are specifically set forth in this Indenture and no others.

 This Section 9.01(b) shall be in lieu of Section 315(a) of the TIA and such Section 315(a) is hereby expressly excluded
from this Indenture, as permitted by the TIA. 
 (c) In the absence of bad faith on their part, the Trustee and the Agents may conclusively
rely, as to the truth of the statements and the correctness of the opinions expressed therein, upon certificates or opinions furnished to the Trustee and the Agents and conforming to the requirements of this Indenture. The Trustee and the Agents,
however, shall examine any certificates and opinions which by any provision hereof are specifically required to be delivered to the Trustee or the Agents to determine whether or not they conform on their face to the requirements of this Indenture,
but need not confirm or investigate the accuracy of mathematical calculations or other facts stated therein 
 (d) Neither the Agents nor the
Trustee may be relieved from liability for their own gross negligent action, their own negligent failure to act, or their own willful misconduct, except that: 
 (1) this paragraph does not limit the effect of Section 9.01(b); 
 (2) the Trustee shall not be liable for any error of judgment made in good faith by a Responsible Officer, unless it is proved that the
Trustee was negligent in ascertaining the pertinent facts; and 
 (3) the Trustee shall not be liable with respect to any
action it takes or omits to take in good faith in accordance with this Indenture or a direction received by it pursuant to Section 8.05. 
 This Section 9.01(d) shall be in lieu of Sections 315(d)(1), 315(d)(2) and 315(d)(3) of the TIA and such Sections are hereby expressly excluded from this Indenture as permitted by the TIA. 
 (e) No provision of this Indenture shall require the Trustee or any Agent to expend or risk its own funds or otherwise incur any financial liability in
the performance of any of its duties hereunder or in the exercise of any of its rights or powers unless the Trustee or any such Agent shall have received adequate security or indemnity in its opinion against potential costs and liabilities incurred
by it relating thereto. 
 (f) Every provision of this Indenture that in any way relates to the Trustee or an Agent is subject to subsections
(a), (b), (c), (d) and (e) of this Section 9.01. 
  

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 (g) Neither the Trustee nor any Agent shall be liable for interest on any money received by it except as
the Trustee or any Agent may agree in writing with the Company. Money held in trust by the Trustee or any Agent need not be segregated from other funds except to the extent required by law. 
 (h) Neither the Trustee nor any Agent shall be liable for any delays occurring as a result of force majeure. 
 Section 9.02 Rights of Trustee and Agents. 
 (a) Subject to Section 9.01: 
 (1) The Trustee and the Agents may rely conclusively and
shall be protected in acting or refraining from acting upon any document believed by any of them to be genuine and to have been signed or presented by the proper person. Neither the Trustee nor the Agents need investigate any fact or matter stated
in the document. 
 (2) Before the Trustee or any Agent acts or refrains from acting, it may require at the expense of the
Company an Officers’ Certificate or an Opinion of Counsel. Neither the Trustee nor the Agents shall be liable for any action any of them takes or omits to take in good faith in reliance on such Officers’ Certificate or Opinion of Counsel.

 (3) Each of the Agents and the Trustee may act or perform any duties hereunder either directly or by or through agents,
attorneys or custodians, and neither the Trustee nor any Agent shall be responsible for any misconduct or negligence on the part of any such agent, attorney or custodian appointed by the Trustee or any Agent with due care. 
 (4) Neither the Trustee nor any Agent shall be liable for any action any of them takes or omits to take in good faith which any of them
believes to be authorized or within its rights or powers. 
 (5) Each of the Agents and the Trustee may consult with counsel
of their selection, and the advice or opinion of such counsel as to matters of law shall be full and complete authorization and protection in respect of any such action taken, omitted or suffered by any of them hereunder in good faith and in
accordance with the advice or opinion of such counsel. 
 (6) The Trustee shall be under no obligation to exercise any of the
rights or powers vested in it by this Indenture or to institute, conduct or defend any litigation hereunder or in relation hereto at the request or direction of any of the Holders pursuant to this Indenture, unless such Holders shall have offered to
the Trustee security or indemnity satisfactory to the Trustee against the costs, expenses and liabilities which might be incurred by it in compliance with such request or direction. 
 (7) Neither the Agents nor the Trustee shall be bound to make any investigation into the facts or matters stated in any resolution,
certificate, statement, 
  

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 instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other
evidence of indebtedness or other paper or document, but the Trustee or any Agent, in its discretion, may make such further inquiry or investigation into such facts or matters as it may see fit, and, if the Trustee or any Agent shall determine to
make such further inquiry or investigation, it shall be entitled to examine the books, records and premises of the Company, personally or by agent or attorney at the sole cost of the Company, and shall incur no liability or additional liability of
any kind by reason of such inquiry or investigation. 
 (8) Neither the Trustee nor the Agents shall be deemed to have notice
or knowledge of any Default or Event of Default, or Fundamental Change unless a Responsible Officer of both the Trustee and the Agents have actual knowledge thereof or unless written notice of any event which is in fact such a Default is received by
the Trustee at the Corporate Trust Office and the Agents at their respective addresses set forth in Section 12.02 hereof, and such notice references the Securities and this Indenture. The Agents and the Trustee agree to notify each other if
they have actual knowledge of a Default or Event of Default or Fundamental Change. In the absence of receipt of such notice or actual knowledge, the Trustee and the Agents may conclusively assume that there is no Default, Event of Default, or
Fundamental Change. 
 (9) The rights, privileges, protections, immunities and benefits given to the Trustee and the Agents,
including, without limitation, their right to be indemnified, are extended to, and shall be enforceable by, the Trustee and the Agents in each of their respective capacities hereunder, including, without limitation as Paying Agent, Authenticating
Agent, Registrar, Transfer Agent and Conversion Agent, and to each agent, custodian and other Person employed to act hereunder. 
 (10) Neither the Trustee nor the Agents shall have any duty to inquire as to the performance of the Company of its covenants and other obligations hereunder. 
 Section 9.03 Individual Rights of Trustee and Agents. The Trustee in its individual or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the Company or an
Affiliate of the Company with the same rights it would have if it were not Trustee. Any Agent may do the same with like rights. However, the Trustee is subject to Sections 9.10 and 9.11. 
 Section 9.04 Trustee’s and Agents’ Disclaimer. Neither the Trustee nor the Agents make any representation as to the validity or
adequacy of this Indenture or the Securities. They shall not be accountable for the Company’s use of the proceeds from the Securities and they shall not be responsible for any statement in the Securities other than the Authenticating Agent for
its certificate of authentication. 
 Section 9.05 Notice of Default or Events of Default. If a Default or an Event of Default
occurs and is continuing and if it is known to a Responsible Officer of the Trustee, the Trustee shall mail to each Holder of a Security notice of all uncured Defaults or Events of Default known to it within 90 days after it occurs or, if later,
within 30 days after it becomes known to the Trustee. However, the Trustee may withhold the notice if and for so long as a committee of its 
  

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 Trust Officers in good faith determines that withholding notice is in the interests of Holders of Securities, except in
the case of a Default or an Event of Default in payment of the principal of, or premium, if any, or interest on any Security when due or in the payment of any purchase obligation, or the Company’s failure to convert Securities when obligated to
convert them. This Section 9.05 is in lieu of section 315(b) of the TIA and such provision is expressly excluded from this Indenture as permitted by the TIA. 
 Section 9.06 Reports by Trustee to Holders. 
 (a) If a report is required by TIA
Section 313, within 60 days after each May 15, beginning with the May 15 following the date of this Indenture, the Trustee shall mail to each Holder of Securities a brief report dated as of such May 15 that complies with TIA
Section 313(a). If required by TIA Section 313, the Trustee also shall comply with TIA Sections 313(b)(2) and (c). 
 (b) A copy of
each report at the time of its mailing to Holders of Securities shall be mailed to the Company and, to the extent required by the TIA, filed with the SEC, and each stock exchange, if any, on which the Securities are listed. The Company shall notify
the Trustee whenever the Securities become listed on any stock exchange or listed or admitted to trading on any quotation system and any changes in the stock exchanges or quotation systems on which the Securities are listed or admitted to trading
and of any delisting thereof. 
 Section 9.07 Compensation and Indemnity. 
 (a) The Company shall pay to the Trustee and the Agents from time to time such compensation (as agreed to from time to time by the Company and the Trustee
and the Company and each Agent in writing) for their services (which compensation shall not be limited by any provision of law in regard to the compensation of a trustee of an express trust). The Company shall reimburse the Trustee and the Agents
upon request for all reasonable disbursements, expenses and advances incurred or made by them. Such expenses may include the reasonable compensation, disbursements and expenses of the agents and counsel of the Trustee and the Agents. 
 (b) The Company shall indemnify and hold harmless the Trustee and each Agent or any predecessor Trustee or any Agent (which for purposes of this
Section 9.07 shall include their officers, directors, employees and agents) for, and hold them harmless against, any and all loss, liability or expense including taxes (other than franchise taxes and taxes based upon, measured by or determined
by the income of the Trustee or any Agent), incurred by them in connection with the acceptance or administration of their duties under this Indenture or any action or failure to act as authorized or within the discretion or rights or powers
conferred upon the Trustee or any Agent hereunder including the reasonable costs and expenses of the Trustee or any Agent and their counsel in defending (including reasonable legal fees and expenses whether incurred before trial, at trial, on appeal
or in any bankruptcy or arbitration or other administrative proceeding) itself against any claim or liability in connection with the exercise or performance of or failure to exercise or perform any of its powers or duties hereunder. Each of the
Trustee and each Agent shall notify the Company promptly of any claim asserted against the Trustee or any Agent for which any of them may seek indemnity. The Company need not pay for any settlement effected without its prior written consent, which
shall not be unreasonably withheld. 
  

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 (c) The Company need not reimburse the Trustee or any Agent for any expense or indemnify any of them
against any loss or liability incurred by any of them resulting from their gross negligence, willful misconduct or bad faith. 
 (d) To
secure the Company’s payment obligations in this Section 9.07, the Trustee and each Agent shall have a senior claim to which the Securities are hereby made subordinate on all money or property held or collected by the Trustee or any Agent.
The obligations of the Company under this Section 9.08 shall survive the satisfaction and discharge of this Indenture or the resignation or removal of the Trustee or any Agent. 
 (e) When the Trustee or an Agent incurs expenses or renders services after an Event of Default specified in clause (7) or (8) of
Section 8.01(a) occurs, the expenses and the compensation for the services are intended to constitute expenses of administration under any Bankruptcy Law. The provisions of this Section 9.07 shall survive the termination of this Indenture
and the resignation or removal of the Trustee or any Agent. 
 (f) To the extent permissible by the TIA, in no event shall the Trustee or any
Agent be liable for special, indirect, punitive or consequential losses or damages of any kind whatsoever (including, without limitation, lost profits) even if such losses or damages were forseeable. 
 Section 9.08 Replacement of Trustee or Agents. 
 (a) The Trustee and each Agent may resign by so notifying the Company. The Holders of a majority in aggregate principal amount of the Securities then outstanding may remove the Trustee by so notifying the Trustee and
the Company and may, with the Company’s written consent, appoint a successor Trustee. The Company may remove the Trustee or any Agent at any time, so long as no Default or Event of Default has occurred and is continuing, and appoint a successor
Trustee or successor Agent in accordance with this Section 9.08 if (i) the Trustee or the applicable Agent fails to comply with Section 9.10; (ii) the Trustee or the applicable Agent, as applicable, is adjudged bankrupt or
insolvent; (iii) a receiver or other public officer takes charge of the Trustee or the applicable Agent, as applicable, or its property; or (iv) the Trustee or the applicable Agent, as applicable, becomes incapable of acting. 

(b) If the Trustee or an Agent resigns or is removed or if a vacancy exists in the office of Trustee or in any Agent capacity for any reason, the
Company shall promptly appoint a successor Trustee or successor Agent, as applicable. The resignation or removal of a Trustee shall not be effective until a successor Trustee or successor Agent, as the case may be, shall have delivered the written
acceptance of its appointment as described below. 
 (c) If a successor Trustee or Agent, as applicable, does not take office within 45 days
after the retiring Trustee or Agent resigns or is removed, the retiring Trustee or Agent, as applicable, the Company or the Holders of 10% in principal amount of the Securities then outstanding may petition any court of competent jurisdiction for
the appointment of a successor Trustee or Agent, as applicable, at the expense of the Company. 
  

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 (d) If the Trustee or an Agent fails to comply with Section 9.10, any Holder may petition any court
of competent jurisdiction for the removal of the Trustee or Agent, as applicable, and the appointment of a successor Trustee or Agent. 
 (e)
A successor Trustee or successor Agent, as applicable, shall deliver a written acceptance of its appointment to the retiring Trustee or retiring Agent, as applicable, and to the Company. Immediately after that, the retiring Trustee or retiring
Agent, as applicable, shall transfer all property held by it as Trustee or Agent to the successor Trustee or successor Agent, as applicable, and be released from its obligations (exclusive of any liabilities that the retiring Trustee or the retiring
Agent, as applicable, may have incurred while acting as Trustee or Agent) hereunder, the resignation or removal of the retiring Trustee or retiring Agent, as applicable, shall become effective, and the successor Trustee or successor Agent shall have
all the rights, powers and duties of the Trustee or Agent, as applicable, under this Indenture. A successor Trustee or successor Agent, as applicable, shall mail notice of its succession to each Holder. 
 (f) A retiring Trustee or retiring Agent shall not be liable for the acts or omissions of any successor Trustee or successor Agent, as applicable, after
its succession. 
 (g) Notwithstanding replacement of the Trustee or an Agent pursuant to this Section 9.08, the Company’s
obligations under Section 9.07 shall continue for the benefit of the retiring Trustee or Agent. 
 Section 9.09 Successor
Trustee or Agent by Merger, etc. If the Trustee or an Agent consolidates with, merges or converts into, or transfers all or substantially all of its corporate trust business (including the administration of this Indenture) to, another
corporation, the resulting, surviving or transferee corporation, without any further act, shall be the successor Trustee or Agent; provided such transferee corporation qualify and be eligible under Section 9.10. Such successor Trustee or
Agent shall promptly distribute notice of its succession to the Company and each Holder. 
 Section 9.10 Eligibility;
Disqualification. The Trustee and the Agents shall always satisfy the requirements of paragraphs (1), (2) and (5) of TIA Section 310(a). The Trustee and the Agents (or their parent holding company) shall have a combined capital
and surplus of at least $50,000,000 as set forth in its most recent published annual report of condition. If at any time the Trustee or the Agents shall cease to satisfy any such requirements, it shall resign immediately in the manner and with the
effect specified in this Article 9. The Trustee and the Agents shall be subject to the provisions of TIA Section 310(b). Nothing herein shall prevent the Trustee from filing with the SEC the application referred to in the penultimate paragraph
of TIA Section 310(b). 
 Section 9.11 Preferential Collection of Claims against Company. The Trustee shall comply with TIA
Section 311(a), excluding any creditor relationship listed in TIA Section 311(b). A Trustee who has resigned or been removed shall be subject to TIA Section 311(a) to the extent indicated therein. 
  

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 ARTICLE 10 
 SATISFACTION AND DISCHARGE OF INDENTURE 
 Section 10.01 Satisfaction and Discharge of
Indenture. 
 (a) This Indenture shall cease to be of further force and effect (except as to any surviving rights of conversion,
registration of transfer or exchange of Securities herein expressly provided for and except as further provided below), and the Trustee, on demand of and at the expense of the Company, shall execute proper instruments acknowledging satisfaction and
discharge of this Indenture, when either: 
 (A) all Securities theretofore authenticated and delivered (other than
(i) Securities which have been destroyed, lost or stolen and which have been replaced as provided in Section 2.07 and (ii) Securities for whose payment money has theretofore been deposited in trust and thereafter repaid to the Company
as provided in Section 10.03) have been delivered to the Transfer Agent for cancellation; or 
 (B) all such Securities
not theretofore delivered to the Transfer Agent for cancellation, 
 (i) have become due and payable, or 
 (ii) will become due and payable at the Final Maturity Date within one year; provided in the case of clause (B), that 
 (1) the Company has deposited with the Trustee or a Paying Agent (other than the Company or any of its Affiliates) as trust funds in
trust for the purpose of and in an amount sufficient to pay and discharge all indebtedness related to such Securities not theretofore delivered to the Transfer Agent for cancellation, for principal and interest to the date of such deposit (in the
case of Securities which have become due and payable) or to the Final Maturity Date, as the case may be; 
 (2) the Company
has paid or caused to be paid all other sums payable hereunder by the Company; and 
 (3) the Company has delivered to the
Trustee an Officers’ Certificate and an Opinion of Counsel, each stating that all conditions precedent herein relating to the satisfaction and discharge of this Indenture have been complied with. 
 (b) Notwithstanding the satisfaction and discharge of this Indenture, the obligations of the Company with respect to the conversion privilege and the
Conversion Rate of the Securities pursuant to Article 4, the obligations of the Company to the Trustee under Section 9.07 and, if money shall have been deposited with the Trustee pursuant to clause (1) of Section 10.01(a), the
provisions of Sections 2.03, 2.04, 2.05, 2.06, 2.07, 2.12, 6.01 and 12.05, Article 4, and this Article 10, shall survive until the Securities have been paid in full. 
  

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 Section 10.02 Application of Trust Money. Subject to the provisions of Section 10.03,
the Trustee or a Paying Agent shall hold in trust, for the benefit of the Holders, all money deposited with it pursuant to Section 10.01 and shall apply the deposited money in accordance with this Indenture and the Securities to the payment of
the principal of and interest on the Securities. 
 Section 10.03 Repayment to Company. 
 (a) The Trustee and each Paying Agent shall promptly pay to the Company upon request by the Company any excess money identified by the Company in writing
(1) deposited with them pursuant to Section 10.01 and (2) held by them at any time. 
 (b) The Trustee and each Paying Agent
shall, subject to applicable abandonment property laws, pay to the Company upon request any money held by them for the payment of principal or interest that remains unclaimed for two years after a right to such money has matured; provided,
however, that the Trustee or such Paying Agent, before being required to make any such payment, may at the expense of the Company cause to be mailed to each Holder entitled to such money notice that such money remains unclaimed and that after a
date specified therein, which shall be at least 30 days from the date of such mailing, any unclaimed balance of such money then remaining will be repaid to the Company. After payment to the Company, Holders entitled to money must look to the Company
for payment as general creditors unless an applicable abandoned property law designates another person. 
 Section 10.04
Reinstatement. If the Trustee or any Paying Agent is unable to apply any money in accordance with Section 10.02 by reason of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining,
restraining or otherwise prohibiting such application, then the Company’s obligations under this Indenture and the Securities shall be revived and reinstated as though no deposit had occurred pursuant to Section 10.01 until such time as
the Trustee or such Paying Agent is permitted to apply all such money in accordance with Section 10.02; provided, however, that if the Company has made any payment of the principal of or interest on any Securities because of the
reinstatement of its obligations, the Company shall be subrogated to the rights of the Holders of such Securities to receive any such payment from the money held by the Trustee or such Paying Agent. 
 ARTICLE 11 
 AMENDMENTS; SUPPLEMENTS
AND WAIVERS 
 Section 11.01 Without Consent of Holders. 
 (a) The Company, the Trustee and the Agents may amend or supplement this Indenture or the Securities without notice to or consent of any Holder of a
Security for the purpose of: 
 (1) evidencing a successor to the Company and the assumption by that successor of the
Company’s obligations under this Indenture and the Securities; 
  

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 (2) adding to the Company’s covenants for the benefit of the Holders or surrendering
any right or power conferred upon the Company; 
 (3) securing the Company’s obligations or adding guarantees in respect
of the Securities and the Indenture; 
 (4) evidencing and providing for the acceptance of the appointment of a successor
trustee or agent in accordance with Article 9; 
 (5) making any change to comply with the requirements of the SEC in order to
effect or maintain the qualification of this Indenture under the TIA, as contemplated by this Indenture or otherwise; 
 (6)
curing any ambiguity, omission, defect or inconsistency in this Indenture; or 
 (7) making any changes to the Indenture of a
formal, minor or technical nature or that are necessary to correct a manifest error or to comply with mandatory provisions of applicable law as evidenced by an opinion of counsel, so long as such change does not adversely affect the rights of the
Holders in any material respect. 
 Section 11.02 With Consent of Holders. 
 (a) The Company, the Trustee and the Agents may amend or supplement this Indenture or the Securities with the written consent of the Holders of at least a
majority in aggregate principal amount of the Securities then outstanding. However, subject to Section 11.04, without the written consent of each Holder affected, an amendment, supplement or waiver may not: 
 (1) alter the manner of calculation or rate of accrual of interest on, or any Additional Interest with respect to, any Security or change
the time of payment of any installment of interest on any Security; 
 (2) make any of the Securities payable in money or
securities other than that stated in the Securities; 
 (3) change the stated maturity of any Security; 
 (4) reduce the principal amount or Fundamental Change Purchase Price (including any Make Whole Premium payable) (as applicable) with
respect to any of the Securities, or any Additional Interest, or the amount payable upon purchase pursuant to Article 3, with respect to any Security; 
 (5) make any change that adversely affects the rights of Holders to require the Company to purchase Securities at the option of Holders; 
  

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 (6) impair the right to institute suit for the enforcement of any payment on or with
respect to any Security or with respect to the conversion of any Security; 
 (7) change the currency of payment of principal
of, or interest on, the Securities; 
 (8) except as otherwise permitted or contemplated by Section 4.11, adversely
affect the conversion rights of the Securities; 
 (9) modify the subordination provisions of the Securities in a manner
adverse to the Holders; or 
 (10) change the percentage in aggregate principal amount of Securities outstanding necessary to
modify or amend this Indenture or to waive any past Default. 
 (b) Without limiting the provisions of Section 11.02(a) hereof, the
Holders of a majority in principal amount of the Securities then outstanding may, on behalf of all the Holders of all Securities, (i) waive compliance by the Company with the restrictive provisions of this Indenture, and (ii) waive any
past Default of Event of Default under this Indenture and its consequences, except an uncured failure to pay when due the principal amount, accrued and unpaid interest, accrued and unpaid Additional Interest or Fundamental Change Purchase Price, or
in the obligation to deliver ADSs, cash, or a combination thereof, if any and as applicable, or in respect of any provision which under this Indenture cannot be modified or amended without the consent of the Holder of each outstanding Security
affected. 
 (c) After an amendment, supplement or waiver under this Section 11.02 becomes effective, the Company shall promptly mail to
the Holders affected thereby a notice briefly describing the amendment, supplement or waiver. Any failure of the Company to mail such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such amendment,
supplement or waiver. 
 Section 11.03 Compliance with Trust Indenture Act. Every amendment to or supplement of this Indenture or
the Securities shall comply with the TIA as in effect at the date of such amendment or supplement. 
 Section 11.04 Revocation and
Effect of Consents. 
 (a) Until an amendment, supplement or waiver becomes effective, a consent to it by a Holder is a continuing consent
by the Holder and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting Holder’s Security, even if notation of the consent is not made on any Security. However, any such Holder or
subsequent Holder may revoke the consent as to its Security or portion of a Security if the Trustee receives the notice of revocation before the date the amendment, supplement or waiver becomes effective. 
 (b) After an amendment, supplement or waiver becomes effective, it shall bind every Holder of a Security. 
  

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 Section 11.05 Notation on or Exchange of Securities. If an amendment, supplement or waiver
changes the terms of a Security, the Trustee may require the Holder of the Security to deliver it to the Transfer Agent. The Transfer Agent may place an appropriate notation on the Security about the changed terms and return it to the Holder.
Alternatively, if the Company or the Trustee so determines, the Company in exchange for the Security shall issue and the Authenticating Agent shall authenticate a new Security that reflects the changed terms. 
 Section 11.06 Trustee to Sign Amendments, etc. The Trustee and the Agents shall sign any amendment or supplemental indenture authorized
pursuant to this Article 11 if the amendment or supplemental indenture does not adversely affect the rights, duties, liabilities or immunities of the Trustee or the Agents. If it does, the Trustee and the Agents may, in their sole discretion, but
need not sign it. In signing or refusing to sign such amendment or supplemental indenture, the Trustee and the Agents shall be entitled to receive and, subject to Section 9.01, shall be fully protected in relying upon, an Opinion of Counsel
stating that such amendment or supplemental indenture is authorized or permitted by this Indenture. The Company may not sign an amendment or supplemental indenture until the Board of Directors approves it. 
 Section 11.07 Effect of Supplemental Indentures. Upon the execution of any supplemental indenture under this Article 11, this Indenture shall
be modified in accordance therewith, and such supplemental indenture shall form a part of this Indenture for all purposes; and every Holder of Securities theretofore or thereafter authenticated and delivered hereunder shall be bound thereby.

 ARTICLE 12 
 MISCELLANEOUS 
 Section 12.01 Trust Indenture Act Controls. If any provision of this Indenture limits, qualifies
or conflicts with the duties imposed by any of Sections 310 to 317, inclusive, of the TIA through operation of Section 318(c) thereof, such imposed duties shall control. 
 Section 12.02 Notices. Any demand, authorization notice, request, consent or communication shall be given in writing and delivered in person
or mailed by first-class mail, postage prepaid, addressed as follows or transmitted by facsimile transmission (confirmed by delivery in person or mail by first-class mail, postage prepaid, or by guaranteed overnight courier) to the following
facsimile numbers: 
 If to the Company, to: 
 China Medical Technologies, Inc. 
 No. 24 Yong Chang North Road, 
 Beijing Economic-Technological Development Area 
 Beijing 100176, China 
 Attention: Chief Financial Officer 
 Fax: +86-10-6788-9588 
  

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 with a copy to: 
 Simpson Thacher & Bartlett LLP 
 35/F, ICBC Tower 
 3 Garden Road 
 Central Hong Kong 

China 
 Attention: Chris Lin 
 Fax: +852-2869-7694 
 if to the Trustee, to:

 Wilmington Trust Company 
 Rodney Square North 
 1100 N. Market Street 
 Wilmington, Delaware 19890-0001 
 Attention: Corporate Capital Markets Services 
 (China Medical Technologies, Inc. 3.50% Convertible Senior Subordinated Notes due 2011) 
 Fax: 302-636-4145 
 if to the Initial Agent:

 Citibank, N.A. 
 388 Greenwich
Street 
 New York, New York 10013 
 Attention: Agency and Trust 
 Fax: 212-657-1020 
 Such notices or communications shall be effective when received. 
 The Company or the Trustee by notice to
the other may designate additional or different addresses for subsequent notices or communications. Notice to or from the Trustee shall not be via electronic mail. Notices to the Trustee via facsimile shall promptly be followed by the original
written notice. 
 Any notice or communication mailed to a Holder of a Security shall be mailed by first-class mail or delivered by an
overnight delivery service to it at its address shown on the register kept by the Registrar. 
 Failure to mail a notice or communication to
a Holder of a Security or any defect in it shall not affect its sufficiency with respect to other Holders of Securities. If a notice or communication to a Holder of a Security is mailed in the manner provided above, it is duly given, whether or not
the addressee receives it. 
 If the Company mails any notice to a Holder of a Security, it shall mail a copy to the Trustee and each Agent.

  

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 Section 12.03 Communications by Holders with other Holders. Holders of Securities may
communicate pursuant to TIA Section 312(b) with other Holders of Securities with respect to their rights under this Indenture or the Securities. The Company, the Trustee, the Agents and any other person shall have the protection of TIA
Section 312(c). 
 Section 12.04 Certificate and Opinion as to Conditions Precedent. 
 (a) Upon any request or application by the Company to the Trustee or any Agent to take any action under this Indenture, the Company shall furnish to the
Trustee or the Agents at the request of the Trustee or the Agents: 
 (1) an Officers’ Certificate stating that, in the
opinion of the signers, all conditions precedent (including any covenants, compliance with which constitutes a condition precedent), if any, provided for in this Indenture relating to the proposed action have been complied with; and 
 (2) an Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent (including any covenants, compliance
with which constitutes a condition precedent) have been complied with. 
 (b) Each Officers’ Certificate and Opinion of Counsel with
respect to compliance with a condition or covenant provided for in this Indenture shall include: 
 (1) a statement that the
person making such certificate or opinion has read such covenant or condition; 
 (2) a brief statement as to the nature and
scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based; 
 (3) a statement that, in the opinion of such person, he or she has made such examination or investigation as is necessary to enable him or her to express an informed opinion as to whether or not such covenant or condition has been complied
with; and 
 (4) a statement as to whether or not, in the opinion of such person, such condition or covenant has been complied
with; 
 provided, however, that with respect to matters of fact an Opinion of Counsel may rely on an Officers’ Certificate or certificates of
public officials. 
 Section 12.05 Record Date for Vote or Consent of Holders of Securities. The Company (or, in the event
deposits have been made pursuant to Section 10.01, the Trustee) may set a record date for purposes of determining the identity of Holders entitled to vote or consent to any action by vote or consent authorized or permitted under this Indenture,
which record date shall not be more than 30 days prior to the date of the commencement of solicitation of such action. Notwithstanding the provisions of Section 11.04, if a record date is fixed, those persons who were Holders of Securities at
the close of business on such record date (or their duly designated 
  

 72 

 proxies), and only those persons, shall be entitled to take such action by vote or consent or to revoke any vote or
consent previously given, whether or not such persons continue to be Holders after such record date. 
 Section 12.06 Rules by
Trustee, Paying Agent, Registrar and Conversion Agent. The Trustee may make reasonable rules (not inconsistent with the terms of this Indenture) for action by or at a meeting of Holders. Any Agent may make reasonable rules for its functions.

 Section 12.07 Legal Holidays. A “Legal Holiday” is a Saturday, Sunday or a day on which state or federally chartered
banking institutions in New York, New York, Wilmington, Delaware are authorized or obligated to close. If a payment date is a Legal Holiday, payment shall be made on the next succeeding day that is not a Legal Holiday, and no interest shall accrue
for the intervening period. If a Regular Record Date is a Legal Holiday, the record date shall not be affected. 
 Section 12.08
Governing Law. This Indenture and the Securities shall be governed by, and construed in accordance with, the laws of the State of New York. 
 Section 12.09 Submission to Jurisdiction. The parties hereby submit to the non-exclusive jurisdiction of any United States Federal or New York State court sitting in the Borough of Manhattan in the City of New York solely for
the purpose of any legal action or proceeding brought to enforce their obligations hereunder or with respect to any Security. 
 As long as
any of the Securities remain outstanding or the parties hereto have any obligation under this Indenture, the Company shall have an authorized agent upon whom process may be served in any such legal action or proceeding. Service of process upon such
agent and written notice of such service mailed or delivered to the Company shall to the extent permitted by law be deemed in every respect effective service of process upon the Company in any such legal action or proceeding and, if it fails to
maintain such an agent, any such process or summons may be served by mailing a copy thereof by registered mail, or a form of mail substantially equivalent thereto, addressed to it at its address as provided for notices hereunder. The Company hereby
appoints CT Corporation System at 111 Eighth Avenue, New York, New York 10011, as its agent for such purposes, and covenants and agrees that service of process in any legal action or proceeding may be made upon it at such office of such agent.

 The Company irrevocably waives, to the fullest extent permitted by law, any objection that it may now or hereafter have to the laying of
venue of any such action or proceeding in the Supreme Court of the State of New York, County of New York or the United States District Court for the Southern District of New York and any claim that any such action or proceeding brought in any such
court has been brought in an inconvenient forum. 
 The Company irrevocably agrees that, should any such action or proceeding be brought
against it arising out of or in connection with this Indenture, no immunity (to the extent that it may now or hereafter exist, whether on the ground of sovereignty or otherwise) from such action or proceeding, from attachment (whether in aid of
execution, before judgment or otherwise) of its property, assets or revenues, or from execution or judgment wherever brought or made, shall be claimed by it or on its behalf or with respect to its property, assets or revenues, any such immunity
being hereby irrevocably waived by the Company to the fullest extent permitted by law. 
  

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 Section 12.10 Judgment Currency. In respect of any judgment or order given or made for any
amount due hereunder that is expressed and paid in a currency (the “judgment currency”) other than United States dollars, the Company will indemnify the Trustee and the Agents against any loss incurred by the Trustee or any Agent as a
result of any variation as between (a) the rate of exchange at which the United States dollar amount is converted into the judgment currency for the purpose of such judgment or order and (b) the rate of exchange at which the Trustee or any
Agent is able to purchase United States dollars with the amount of the judgment currency actually received by the Trustee or any Agent. The foregoing indemnity shall constitute a separate and independent obligation of the Company and shall continue
in full force and effect notwithstanding any such judgment or order as aforesaid. The term “rate of exchange” shall include any premiums and costs of exchange payable in connection with the purchase of or conversion into United States
dollars. 
 Section 12.11 No Adverse Interpretation of other Agreements. This Indenture may not be used to interpret another
indenture, loan or debt agreement of the Company or a Subsidiary of the Company. Any such indenture, loan or debt agreement may not be used to interpret this Indenture. 
 Section 12.12 No Recourse against Others. All liability described in paragraph 17 of the Securities of any director, officer, employee or shareholder, as such, of the Company hereby is waived and released
by each of the Holders. 
 Section 12.13 No Security Interest Created. Nothing in this Indenture or in the Securities, express or
implied, shall be construed to constitute a security interest under the Uniform Commercial Code or similar legislation, now in effect or hereafter enacted and made effective, in any jurisdiction. 
 Section 12.14 Successors. All agreements of the Company in this Indenture and the Securities shall bind its successor. All agreements of the
Trustee in this Indenture shall bind its successor. 
 Section 12.15 Multiple Counterparts. The parties may sign multiple
counterparts of this Indenture. Each signed counterpart shall be deemed an original, but all of them together represent the same agreement. 
 Section 12.16 Separability. If any provisions in this Indenture or in the Securities shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be
affected or impaired thereby. 
 Section 12.17 Table of Contents, Headings, etc. The table of contents, cross-reference sheet and
headings of the Articles and Sections of this Indenture have been inserted for convenience of reference only, are not to be considered a part hereof, and shall in no way modify or restrict any of the terms or provisions hereof. 
 [SIGNATURE PAGE FOLLOWS] 
  

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 IN WITNESS WHEREOF, the parties hereto have hereunto set their hands as of the date and year first above
written. 
  

			
	CHINA MEDICAL TECHNOLOGIES, INC.
		
	By:	 	 /s/ Takyung Tsang

	Name:	 	Takyung Tsang
	Title:	 	Chief Financial Officer
	
	 WILMINGTON TRUST COMPANY,
 a Delaware banking
corporation, as Trustee

		
	By:	 	 /s/ Geoffrey J. Lewis

	Name:	 	Geoffrey J. Lewis
	Title:	 	Financial Services Officer
	
	 CITIBANK, N.A.,
 a national banking
association, as Initial Agent

		
	By:	 	 /s/ John J. Byrnes

	Name:	 	John J. Byrnes
	Title:	 	Vice President

 Signature Page to the Indenture 

 EXHIBIT A 
 [FORM OF FACE OF SECURITY] 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF
THE DEPOSITORY TRUST COMPANY TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF
FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED
IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITARY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND, UNLESS AND
UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER
NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.1 
 THIS SECURITY AND THE AMERICAN DEPOSITARY SHARES ISSUABLE UPON CONVERSION OF THIS SECURITY, INCLUDING THE
ORDINARY SHARES REPRESENTING SUCH AMERICAN DEPOSITARY SHARES, HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY STATE SECURITIES LAWS. NEITHER THIS SECURITY, THE AMERICAN DEPOSITARY
SHARES, INCLUDING THE ORDINARY SHARES REPRESENTING SUCH AMERICAN DEPOSITARY SHARES, ISSUABLE UPON CONVERSION OF THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN OR THEREIN MAY BE REOFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR
OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, REGISTRATION UNDER THE SECURITIES ACT.2 
 BY ITS ACQUISITION HEREOF, THE HOLDER AGREES TO OFFER, SELL OR OTHERWISE TRANSFER SUCH
SECURITY PRIOR TO THE DATE THAT IS TWO YEARS AFTER THE LATER OF THE ISSUE DATE OF THIS SECURITY (“THE RESALE 
  

	1	This paragraph should be included only if the Security is a Global Security. 

	2	This paragraph to be included only if the Security is a Restricted Security. 

  

 A-2 

 RESTRICTION TERMINATION DATE”) ONLY (A) TO CHINA MEDICAL TECHNOLOGIES, INC. (THE “COMPANY”) OR ANY
SUBSIDIARY THEREOF, (B) PURSUANT TO A REGISTRATION STATEMENT WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A, TO A PERSON IT REASONABLY BELIEVES IS
A QUALIFIED INSTITUTIONAL BUYER AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A, OR (D) PURSUANT
TO ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO THE COMPANY’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSE (D) PRIOR TO THE RESALE
RESTRICTION TERMINATION DATE TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATIONS AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM, AND IN EACH OF THE FOREGOING CASES, TO REQUIRE THAT A CERTIFICATE OF TRANSFER IN THE FORM APPEARING
ON THE OTHER SIDE OF THIS SECURITY IS COMPLETED AND DELIVERED BY THE TRANSFEROR TO THE TRUSTEE. 
 THE AMERICAN DEPOSITARY SHARES ISSUABLE
UPON CONVERSION OF THE SECURITY, INCLUDING THE ORDINARY SHARES REPRESENTING SUCH AMERICAN DEPOSITARY SHARES, ARE SUBJECT TO THE DEPOSIT AGREEMENT (AS SUPPLEMENTED) DATED AUGUST 9, 2005 BETWEEN THE COMPANY AND CITIBANK, N.A., AS DEPOSITARY. IN
CERTAIN CIRCUMSTANCES, THE AMERICAN DEPOSITARY SHARES ISSUABLE UPON CONVERSION OF THE SECURITY WILL BE ISSUED AND DELIVERED IN THE FORM OF RESTRICTED AMERICAN DEPOSITARY SHARES AND WILL BE SUBJECT TO TRANSFER RESTRICTIONS AS SET FORTH IN THE DEPOSIT
AGREEMENT (AS SUPPLEMENTED). 
 THE HOLDER OF THIS SECURITY IS ENTITLED TO THE BENEFITS OF A REGISTRATION RIGHTS AGREEMENT (AS SUCH TERM IS
DEFINED IN THE INDENTURE REFERRED TO ON THE REVERSE HEREOF) AND, BY ITS ACCEPTANCE HEREOF, AGREES TO BE BOUND BY AND TO COMPLY WITH THE PROVISIONS OF SUCH REGISTRATION RIGHTS AGREEMENT.3 
  

	3	This paragraph to be included only if the Security is a Restricted Security. 

  

 A-3 

 CHINA MEDICAL TECHNOLOGIES, INC. 
 3.50% Convertible Senior Subordinated Notes due 2011 
  

			
	No. [     ]:	  	CUSIP: [     ]

 China Medical Technologies, Inc., a company organized under the laws of the Cayman Islands,
promises to pay to [Cede & Co./            ] or registered assigns the principal amount of
                    
($                    ) on November 15, 2011. 
 This Security shall bear interest as specified on the other side of this Security. This Security is convertible as specified on the other side of this Security. 
 Additional provisions of this Security are set forth on the other side of this Security. 
 Dated: 
 SIGNATURE PAGE FOLLOWS 
  

 A-4 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 
  

			
	CHINA MEDICAL TECHNOLOGIES, INC.
		
	By:	 	  

	Name:	 	
	Title:	 	

 Dated: 
 Authenticating Agent’s Certificate of Authentication: 
 This is one of the Securities referred to 
 in the within-mentioned Indenture. 
  

			
	 CITIBANK, N.A.
 as Authenticating
Agent

		
	By:	 	  

		 	Authorized Signatory

  

 A-5 

 [FORM OF REVERSE SIDE OF SECURITY] 
 CHINA MEDICAL TECHNOLOGIES, INC. 
 3.50% CONVERTIBLE SENIOR SUBORDINATED NOTES DUE 2011

 1. INTEREST 
 China Medical
Technologies, Inc., a company organized under the laws of the Cayman Islands (the “Company”, which term shall include any successor corporation under the Indenture hereinafter referred to), promises to pay interest on the principal amount
of this Security at the rate of 3.50% per annum. The Company shall pay interest semiannually on May 15 and November 15 of each year (each an “Interest Payment Date”), commencing May 15, 2007. Each payment of interest
will include interest accrued through the day before the relevant Interest Payment Date (or purchase date, as the case may be). Cash interest will be computed on the basis of a 360-day year comprised of twelve 30-day months. Any payment required to
be made on a day that is not a Business Day shall be made on the next succeeding Business Day. Any reference herein to interest accrued or payable as of any date shall include any Additional Interest accrued or payable on such date as provided in
the Registration Rights Agreement. 
 No sinking fund is provided for the Securities. 
 2. METHOD OF PAYMENT 
 The Company shall pay
interest on this Security (except defaulted interest) to the person who is the Holder of this Security at the close of business on May 1 or November 1, as the case may be, (each, a “Regular Record Date”) next preceding the
related Interest Payment Date. The Holder must surrender this Security to a Paying Agent to collect payment of principal. The Company will pay principal and interest in money of the United States that at the time of payment is legal tender for
payment of public and private debts. The Company may pay principal and interest in respect of any Certificated Security by check or wire payable in such money; provided, however, that a Holder with an aggregate principal amount in excess of
$2,000,000 will be paid by wire transfer in immediately available funds at the election of such Holder if such Holder has provided wire transfer instructions to the Trustee at least 10 Business Days prior to the Payment Date. The Company may mail an
interest check to the Holder’s registered address. Notwithstanding the foregoing, so long as this Security is registered in the name of a Depositary or its nominee, all payments hereon shall be made by wire transfer of immediately available
funds to the account of the Depositary or its nominee. 
 Any wire transfer instructions received by the Trustee will remain in effect until
revoked by the Holder. 
 3. PAYING AGENT, TRANSFER AGENT, REGISTRAR, AUTHENTICATING AGENT AND CONVERSION AGENT 
 Initially, Citibank, N.A. will act as Paying Agent, Transfer Agent, Registrar, Authenticating Agent and Conversion Agent. The Company may change any
Paying Agent, Transfer Agent, Registrar, Authenticating Agent or Conversion Agent without notice to the Holder. The Company or any of its Subsidiaries may, subject to certain limitations set forth in the Indenture, act as Paying Agent. 

 

 A-6 

 4. INDENTURE, LIMITATIONS 
 This Security is one of a duly authorized issue of Securities of the Company designated as its 3.50% Convertible Senior Subordinated Notes Due 2011 (the “Securities”), issued under an Indenture dated as of
November 21, 2006 (together with any supplemental indentures thereto, the “Indenture”), between the Company, the Trustee and the Initial Agent. The terms of this Security include those stated in the Indenture and those required by or
made part of the Indenture by reference to the Trust Indenture Act of 1939, as amended, as in effect on the date of the Indenture. This Security is subject to all such terms, and the Holder of this security is referred to the Indenture and the TIA
for a statement of them. Capitalized terms not defined herein have the meaning ascribed to such terms in the Indenture. 
 The Securities are
unsecured, subordinated obligations of the Company limited to $150,000,000 aggregate principal amount. The Indenture does not limit other debt of the Company or its Subsidiaries, secured or unsecured. 
 5. PURCHASE OF SECURITIES AT OPTION OF HOLDER UPON A FUNDAMENTAL CHANGE 
 If a Fundamental Change occurs prior to the Final Maturity Date, at the option of the Holder and subject to the terms and conditions of the Indenture, the Company shall become obligated to purchase for cash, subject
to certain exceptions described in the Indenture all or any part specified by the Holder (so long as the principal amount of such part is $1,000 or an integral multiple of $1,000) of the Securities held by such Holder on a date specified by the
Company that is not less than 30 nor more than 45 days after the date of the Fundamental Change Company Notice, at a purchase price equal to 100% of the principal amount thereof together with accrued and unpaid interest, if any, and Additional
Interest, if any, to, but excluding, the Fundamental Change Repurchase Date. The Holder shall have the right to withdraw any Fundamental Change Repurchase Notice (in whole or in a portion thereof that is $1,000 or an integral multiple of $1,000) at
any time prior to the close of business on the Business Day next preceding the Fundamental Change Repurchase Date by delivering a written notice of withdrawal to the Paying Agent in accordance with the terms of the Indenture. 
 6. CONVERSION 
 Subject to and upon
compliance with the provisions of the Indenture, a Holder may surrender for conversion into the Company’s ADSs any Security that is $1,000 principal amount or integral multiples thereof. In lieu of delivering ADSs, the Company may satisfy its
conversion obligation with cash or a combination of cash and ADSs. Holders who convert their Securities in connection with certain Fundamental Changes may be entitled to a Make Whole Premium upon conversion in some circumstances. 
  

 A-7 

 7. SENIOR SUBORDINATION 
 To the extent provided in the Indenture, the Securities are subordinated to Senior Indebtedness, of the Company. To the extent provided in the Indenture, Senior Indebtedness must be paid in full before the Securities
may be paid. The Company agrees, and each Security holder by accepting a Security agrees, to the subordination provisions contained in the Indenture and authorizes the Trustee to give it effect and appoints the Trustee as attorney-in-fact for such
purpose. The Securities will be equal in right of payment to our other Senior Subordinated Indebtedness. 
 8. DENOMINATIONS, TRANSFER,
EXCHANGE 
 The Securities are in registered form, without coupons, in denominations of $1,000 principal amount and integral multiples of
$1,000 principal amount. A Holder may register the transfer of or exchange Securities in accordance with the Indenture. The Transfer Agent may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and to
pay any taxes or other governmental charges that may be imposed in relation thereto by law or permitted by the Indenture. 
 9. PERSONS
DEEMED OWNERS 
 The Holder of a Security may be treated as the owner of it for all purposes. 
 10. UNCLAIMED MONEY 
 If money for the
payment of principal or interest remains unclaimed for two years, the Trustee and any Paying Agent will pay the money back to the Company at its written request, subject to applicable unclaimed property law and the provisions of the Indenture. After
that, Holders entitled to money must look to the Company for payment as general creditors unless an applicable abandoned property law designates another person. 
 11. AMENDMENT, SUPPLEMENT AND WAIVER 
 Subject to certain exceptions, the Indenture or the Securities may be
amended or supplemented with the consent of the Holders of at least a majority in aggregate principal amount of the Securities then outstanding, and an existing Default or Event of Default and its consequence or compliance with any provision of the
Indenture or the Securities may be waived in a particular instance with the consent of the Holders of a majority in aggregate principal amount of the Securities then outstanding. Without the consent of or notice to any Holder, the Company and the
Trustee may amend or supplement the Indenture or the Securities as provided in the Indenture. 
 12. SUCCESSOR ENTITY 
 When a successor corporation assumes all the obligations of its predecessor under the Securities and the Indenture in accordance with the terms and
conditions of the Indenture, the predecessor corporation (except in certain circumstances specified in the Indenture) shall be released from those obligations. 
  

 A-8 

 13. DEFAULTS AND REMEDIES 
 Under the Indenture, an Event of Default shall occur if: 
 (1) the Company shall fail to pay when due the
Principal or any Fundamental Change Purchase Price of any Security, including any Make-Whole Premium, when the same becomes due and payable whether at the Final Maturity Date, upon repurchase, acceleration or otherwise, whether or not such payment
is prohibited by the subordination provisions of the Indenture; or 
 (2) the Company shall fail to pay an installment of interest or
Additional Interest, if any, on any of the Securities, which failure continues for 30 days after the date when due, whether or not such payment is prohibited by the subordination provisions of the Indenture; or 
 (3) the Company shall fail to deliver when due all ADSs and any cash (or combination thereof), if any, deliverable upon conversion of the Securities,
which failure continues for 15 days after such delivery date, whether or not such payment is prohibited by the subordination provisions of the Indenture; or 
 (4) the Company shall fail to perform or observe (or obtain a waiver with respect to) any other term, covenant or agreement contained in the Securities or the Indenture for a period of 60 days after receipt by the
Company of a Notice of Default specifying such failure; or 
 (5) the Company shall fail to pay any principal by the end of any applicable
grace period or resulting in acceleration of other Indebtedness of the Company for borrowed money where the aggregate principal amount with respect to which the default or acceleration has occurred exceeds $15 million and such acceleration has not
been rescinded or annulled or such Indebtedness repaid within a period of 30 days after receipt of a Notice of Default, provided that if any such default is cured, waived, rescinded or annulled, then the Event of Default by reason thereof would be
deemed not to have occurred; or 
 (6) the Company pursuant to or within the meaning of any Bankruptcy Law: 
 (A) commences as a debtor a voluntary case or proceeding; or 
 (B) consents to the entry of an order for relief against it in an involuntary case or proceeding or the commencement of any case against
it; 
 (C) consents to the appointment of a Receiver of it or for all or substantially all of its property; or 
 (D) makes a general assignment for the benefit of its creditors; 
 (E) files a petition in bankruptcy or answer or consent seeking reorganization or relief; or 
 (F) consents to the filing of such a petition or the appointment of or taking possession by a Receiver; or 
  

 A-9 

 (7) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:

 (A) grants relief against the Company in an involuntary case or proceeding or adjudicates the Company insolvent or
bankrupt; 
 (B) appoints a Receiver of the Company or for all or substantially all of the property of the Company; or

 (C) orders the winding up or liquidation of the Company; 
 and in each case the order or decree remains unstayed and in effect for 60 consecutive days. 
 The term
“Bankruptcy Law” means Title 11 of the United States Code (or any successor thereto) or any similar foreign, United State federal or state law for the relief of debtors. The term “Receiver” means any receiver, trustee, assignee,
liquidator, sequestrator or similar official under any Bankruptcy Law. 
 Notwithstanding the above, no Event of Default under clauses
(4) or (5) above shall occur until the Trustee notifies the Company in writing upon the written direction of the Holders of at least 25% in aggregate principal amount of the Securities then outstanding, or the Holders of at least 25% in
aggregate principal amount of the Securities then outstanding notify the Company and the Trustee in writing, of the Default (a “Notice of Default”), and the Company does not cure the Default within the time specified in clause (4) or
(5), as applicable, after receipt of such notice. 
 If an Event of Default (other than an Event of Default specified in clause (6) or
(7) above) occurs and is continuing with respect to the Company, the Trustee may, by notice to the Company, and shall upon the written direction of the Holders of at least 25% in aggregate principal amount of the Securities then outstanding,
declare the principal amount and accrued and unpaid interest, if any, and accrued and unpaid Additional Interest, if any, through the date of declaration on all the Securities to be immediately due and payable. Upon such a declaration, such
principal amount and such accrued and unpaid interest, if any, and such accrued and unpaid Additional Interest, if any, shall be due and payable immediately. If an Event of Default specified in clauses (6) or (7) occurs in respect of the
Company and is continuing, the principal amount and accrued but unpaid interest, if any, and accrued and unpaid Additional Interest, if any, on all the Securities shall become and be immediately due and payable without any declaration or other act
on the part of the Trustee or any Holders of Securities. The Holders of a majority in aggregate principal amount of the Securities then outstanding by notice to the Trustee may rescind an acceleration and its consequences if (a) all existing
Events of Default, other than the nonpayment of the principal of the Securities which have become due solely by such declaration of acceleration, have been cured or waived; (b) to the extent the payment of such interest is lawful, interest
(calculated at the rate per annum borne by the Securities) on overdue installments of interest and overdue principal, which has become due otherwise than by such declaration of acceleration, has been paid; (c) the rescission would not conflict
with any judgment or decree of a court of competent jurisdiction; and (d) all payments due to the Trustee and any predecessor Trustee under the Indenture have been made. No such rescission shall 
  

 A-10 

 affect any subsequent Default or impair any right consequent thereto. Holders may not enforce the Indenture or the
Securities except as provided in the Indenture. The Trustee may require indemnity satisfactory to it before it enforces the Indenture or the Securities. Subject to certain limitations, Holders of a majority in aggregate principal amount of the
Securities then outstanding may direct the Trustee in its exercise of any trust or power. The Trustee may withhold from Holders notice of any continuing Default (except a Default in payment of principal or interest) if and so long as it determines
that withholding notice is in their interests. The Company is required to file periodic certificates with the Trustee as to the Company’s compliance with the Indenture and knowledge or status of any Default. 
 14. TRUSTEE DEALINGS WITH THE COMPANY 
 Wilmington Trust Company, the initial Trustee under the Indenture and Citibank, N.A., the Initial Agent under the Indenture, in their individual or any other capacity, may make loans to, accept deposits from and perform services for the
Company or an Affiliate of the Company, and may otherwise deal with the Company or an Affiliate of the Company, as if it were not the Trustee or Agent. 
 15. NO RECOURSE AGAINST OTHERS 
 A director, officer, employee or shareholder, as such, of the Company shall
not have any liability for any obligations of the Company under the Securities or the Indenture nor for any claim based on, in respect of or by reason of such obligations or their creation. The Holder of this Security by accepting this Security
waives and releases all such liability. The waiver and release are part of the consideration for the issuance of this Security. 
 16.
AUTHENTICATION 
 This Security shall not be valid until the Authenticating Agent manually signs the certificate of authentication on the
other side of this Security. 
 17. ABBREVIATIONS AND DEFINITIONS 
 Customary abbreviations may be used in the name of the Holder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the
entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian) and UGMA (= Uniform Gifts to Minors Act). 
 18. INDENTURE TO CONTROL; GOVERNING LAW 
 In the case of any conflict between the provisions of this Security
and the Indenture, the provisions of the Indenture shall control. This Security and the Indenture shall be governed by, and construed in accordance with, the laws of the State of New York. 
 The Company will furnish to any Holder, upon written request and without charge, a copy of the Indenture. Requests may be made to: China Medical
Technologies, Inc., No. 24 Yong Chang North Road, Beijing Economic-Technological Development Area, Beijing 100176, China, Attention: Chief Financial Officer (Fax: +86-10-6788-9588). 
  

 A-11 

 ASSIGNMENT FORM 
 To assign this Security, fill in the form below: 
 I or we assign and transfer this Security to 
  

	
	  
  

	(Insert assignee’s soc. sec. or tax I.D. no.)
	  
  

	  
  

	  
  

	(Print or type assignee’s name, address and zip code)
	and irrevocably appoint
	  

	agent to transfer this Security on the books of the Company. The agent may substitute another to act for him or her.

  

					
		  		  	Your Signature
	Date: ______________________	  		  	  

		  		  	 (Sign exactly as your name appears on the other
 side
of this Security)

 * Signature guaranteed by: 
  

			
	 By:
	 	  

  

	*	If required by the Transfer Agent, the signature shall be guaranteed by an institution which is a member of one of the following recognized signature guaranty programs: (i) the
Securities Transfer Agent Medallion Program (STAMP); (ii) the New York Stock Exchange Medallion Program (MSP); (iii) the Stock Exchange Medallion Program (SEMP); or (iv) such other guaranty program acceptable to the Trustee.

  

 A-12 

 CONVERSION NOTICE 
  

	To:	Citibank, N.A., as Conversion Agent 

 388 Greenwich Street,
14th Floor 
 New York, NY 10013 
 Fax: 212-657-1020 
 Reference is made to the Indenture, dated as of November 21, 2006, by and among China Medical Technologies, Inc., Wilmington Trust Company, as Trustee and Citibank, N.A., as Initial Agent (the
“Indenture”). Defined terms used herein shall have the meanings ascribed thereto in the Indenture. 
 The undersigned owner of this
Security hereby irrevocably exercises the option to convert this Security, or the portion thereof designated below, in accordance with the terms of the Indenture referred to in this Security and as specified below. In the event that the undersigned
exercises such option on and after a Regular Record Date to and including the immediately following Interest Payment Date, the exercise of such option is subject to the undersigned including together with this note the amount of interest to be paid
on this Security on such Interest Payment Date. The undersigned hereby certifies that all taxes due to any governmental authority in connection with the exercise of this conversion option have been or will be, promptly paid. 
 The undersigned hereby requests the following: 
  

	
	 Total principal amount of Global Securit[y][ies]* to be converted:

	 Serial or identifying number of the Rule 144A Global Securit[y][ies]*:

	
	 CUSIP number:

  

	*	Delete bracketed language not applicable. 

 The undersigned owner of this
Security (i) agrees to receive, pursuant to the terms of the Indenture, upon conversion Restricted ADSs and (ii) directs that such Restricted ADSs deliverable upon conversion and any Securit(y)(ies) representing any unconverted principal
amount hereof, be issued and delivered to the registered holder hereof as set forth below. 
 Fill in for: registration of ADSs, if to be delivered, and of
Securities if to be issued, in either case otherwise than to and in the name of the registered holder. 
 Social Security or Other Taxpayer Identifying
Number 
 (Name) 
 (Street Address) 
  

 A-13 

 (City, State and Zip Code) 
 (Please print name and address) 
 Fill in the following additional information for the conversion into ADSs: 
  

	
	 DTC participant account number:

	
	Account number for investor or DTC participant (f/b/o information):
	
	 Contact person at DTC participant:

	
	Daytime telephone number of contact person at DTC participant:
	
	 Email of contact person at DTC participant:

  

	
	Dated:
	
	Signature of Authorized Signer:
	
	Name:
	
	Fax:

 * Signature guaranteed by: 
  

			
	 By:
	 	  

  

	*	If required by the Conversion Agent, the signature shall be guaranteed by an institution which is a member of one of the following recognized signature guaranty programs:
(i) the Securities Transfer Agent Medallion Program (STAMP); (ii) the New York Stock Exchange Medallion Program (MSP); (iii) the Stock Exchange Medallion Program (SEMP); or (iv) such other guaranty program acceptable to the
Trustee. 

  

 A-14 

 FUNDAMENTAL CHANGE PURCHASE NOTICE 
  

	To:	China Medical Technologies, Inc. 

 The undersigned
registered owner of this Security hereby irrevocably acknowledges receipt of a notice from China Medical Technologies, Inc. (the “Company”) as to the occurrence of a Fundamental Change with respect to the Company and requests and instructs
the Company to purchase the entire principal amount of this Security, or the portion thereof (which is $1,000 or an integral multiple thereof) below designated, in accordance with the terms of the Security and the Indenture referred to in the
Security at the Fundamental Change Purchase Price, together with accrued and unpaid interest and Additional Interest, if any, to, but excluding, such date, to the registered Holder hereof. 
  

					
	Dated: ____________________	  		  	  

		  		  	Signature(s)
			
		  		  	If required by the Paying Agent, signature(s) shall be guaranteed by a qualified guarantor institution with membership in an approved signature guarantee program pursuant to Rule 17Ad-15
under the Securities Exchange Act of 1934.
			
		  		  	  

		  		  	Signature Guaranty

 Principal amount to be redeemed 
 (in an integral multiple of $1,000, 
 if less than all): 
 NOTICE: The signature to the foregoing Election must correspond to the Name as written upon the face of this Security in every particular, without any alteration or change whatsoever. 
  

 A-15 

 SCHEDULE OF EXCHANGES OF SECURITIES4 
 The following exchanges, purchases or
conversions of a part of this Global Security have been made: 
  

							
	 Principal Amount of this
 Global Note
Following
 Such Decrease Date of
 Exchange (or Increase)
	  	Authorized Signatory of
Securities Custodian	  	Amount of Decrease in
Principal Amount of this
Global Note	  	 Amount of Increase in
 Principal Amount of
 this Global
Note

  

	4	This schedule should be included only if the Security is a Global Security. 

  

 A-16 

 CERTIFICATE TO BE DELIVERED UPON EXCHANGE OR REGISTRATION 
 OF TRANSFER OF RESTRICTED SECURITIES 
  

	Re:	3.50% Convertible Senior Subordinated Notes Due 2011 (the “Securities”) of China Medical Technologies, Inc. 

 This certificate relates to $                     principal amount of
Securities owned in (check applicable box) 
  

			
	  ̈        book-entry or
	  	  ̈        definitive form by (the “Transferor”).

 The Transferor has requested a Registrar or the Trustee to exchange or register the transfer of
such Securities. 
 In connection with such request and in respect of each such Security, the Transferor does hereby certify that the
Transferor is familiar with transfer restrictions relating to the Securities as provided in Section 2.12 of the Indenture dated as of November 21, 2006 between China Medical Technologies, Inc., Wilmington Trust Company, as trustee, and
Citibank, N.A., as initial agent (the “Indenture”), and the transfer of such Security is being made pursuant to an effective registration statement under the Securities Act of 1933, as amended (the “Securities Act”) or the
transfer or exchange, as the case may be, of such Security does not require registration under the Securities Act because (check applicable box): 
  

	 ̈	Such Security is being acquired for the Transferor’s own account, without transfer. 

  

	 ̈	Such Security is being transferred to the Company or a Subsidiary (as defined in the Indenture) of the Company. 

  

	 ̈	Such security is being transferred to a person the Transferor reasonably believes is a “qualified institutional buyer” (as defined in Rule 144A or any successor provision
thereto (“Rule 144A”) under the Securities Act) that is purchasing for its own account or for the account of a “qualified institutional buyer”, in each case to whom notice has been given that the transfer is being made in
reliance on such Rule 144A, and in each case in reliance on Rule 144A. 

  

	 ̈	Such Security is being transferred pursuant to and in compliance with an exemption from the registration requirements under the Securities Act in accordance with Rule 144 (or any
successor thereto) (“Rule 144”) under the Securities Act. 

  

	 ̈	Such Security is being transferred to a non-U.S. Person in an offshore transaction in compliance with Rule 904 of Regulation S under the Securities Act (or any successor thereto).

  

	 ̈	Such Security is being transferred pursuant to and in compliance with an exemption from the registration requirements of the Securities Act (other than an exemption referred to
above) and as a result of which such Security will, upon such transfer, cease to be a “restricted security” within the meaning of Rule 144 under the Securities Act. 

  

 A-17 

	 ̈	The Transferor acknowledges and agrees that, if the transferee will hold any such Securities in the form of beneficial interests in a Global Note which is a “restricted
security” within the meaning of Rule 144 under the Securities Act, then such transfer can be made only (i) to the Company or any Subsidiary thereof, (ii) pursuant to a registration statement which has been declared effective under the
Securities Act, (iii) pursuant to Rule 144A under the Securities Act and such transferee must be a “qualified institutional buyer” (as defined in Rule 144A) or (iv) pursuant to any other available exemption from the registration
requirements of the Securities Act. 

  

					
	 Date: ____________________
	  		  	  

		  		  	(Insert Name of Transferor)

  

 A-18 

 EXHIBIT B 
 Form of Notice of Transfer Pursuant to Registration Statement 
                     , 200         
 Wilmington Trust Company 
 Rodney Square North 
 1100 N. Market Street 
 Wilmington, DE 19890-0001 
 Attention: Corporate Capital Market Services 
 Citibank, N.A. 
 388 Greenwich Street 
 14th Floor 
 New York, New York 10013 
 Attention: Agency and Trust Services 
  

	 	Re:	China Medical Technologies, Inc. (the “Company”) 3.50% Convertible 

 Senior Subordinated Notes due 2011 (the “Securities”) 
 Ladies and Gentlemen: 
 Please be advised that                      has
transferred $                      aggregate principal amount of the Securities pursuant to an effective Shelf Registration Statement on Form
F-3 (File No. 333-            ). Defined terms used but not defined herein shall have the meanings ascribed thereto in the Indenture, dated as of November 21, 2006, by and
among the Company, Wilmington Trust Company and Citibank, N.A. 
 We hereby certify that the prospectus delivery requirements, if any, of the
Securities Act of 1933 as amended, have been satisfied with respect to the transfer described above and that the above-named beneficial owner of the Securities is named as a “Selling Security Holder” in the Prospectus dated
                    , or in amendments or supplements thereto, and that the aggregate principal amount of the Securities transferred are [a
portion of] the Securities listed in such Prospectus, as amended or supplemented, opposite such owner’s name. 
  

	
	Very truly yours,
	  
  

	             (Name)

  

 B-1 

 EXHIBIT C 
 Form of Opinion of Counsel in Connection with Registration of Securities 
 Wilmington Trust Company 
 Rodney Square North 
 1100 N. Market Street 
 Wilmington, DE 19890-0001 
 Attention: Corporate Capital Market Services

 Citibank, N.A. 
 388 Greenwich Street 
 14th Floor 
 New York, New York 10013 
 Attention: Agency and Trust Services 
  

	 	Re:	China Medical Technologies, Inc. (the “Company”) 3.50% Convertible 

 Senior Subordinated Notes due 2011 (the “Securities”) 
 Ladies and Gentlemen: 
 Reference is made to the Securities issued pursuant to a certain Indenture dated as of November 21, 2006 by and among the Company, Wilmington Trust
Company, as trustee (the “Trustee”), and Citibank, N.A., as Initial Agent (the “Initial Agent”). The Company issued $150,000,000 principal amount of Securities on November 21, 2006 in transactions exempt from
registration under the Securities Act of 1933, as amended (the “Securities Act”). The Company has filed with the Securities and Exchange Commission (the “SEC”) [a] [Amendment No. [    ] to
the] Registration Statement on Form F-3 (File No. 333-            ) (the “Registration Statement”) relating to the registration under the Securities Act of $
                     principal amount of the Securities and the American Depositary Shares of the Company (the “ADSs”)
issuable upon conversion of the Securities being registered. The Registration Statement was declared effective by order of the SEC dated
                    . 
 We have
acted as counsel for the Company in connection with the issuance of the Securities and the preparation and filing of the Registration Statement and are familiar with the Securities, the Indenture, the Registration Statement, the above-mentioned SEC
order and such other documents as are necessary to render this opinion. 
 Based on the foregoing, it is our opinion that (1) the
Registration Statement has become effective under the Securities Act and, to our knowledge, no stop order suspending the effectiveness of the Registration Statement has been issued, (2) assuming that the Securities covered by the Registration
Statement are sold by a relevant Holder specified in the Registration Statement in a manner specified in the Registration Statement, such sale of the Securities will have been duly registered under the Securities Act and (3) the Indenture has
been duly qualified under the Trust Indenture Act of 1939, as amended. 
 Yours truly, 
  

 C-1Registration Rights Agreement, dated as of Nov 21,2006

 EXHIBIT 4.6 
  

 Registration Rights Agreement

 Dated as of November 21, 2006 
 between 
 China Medical Technologies, Inc. 
 and 
 Merrill Lynch, Pierce, Fenner
& Smith 
 Incorporated 
  

 REGISTRATION RIGHTS AGREEMENT 
 This Registration Rights Agreement (the “Agreement”) is made and entered into this 21st day of November, 2006, between China Medical Technologies, Inc., a company incorporated under the laws of the Cayman Islands (the “Company”), and
Merrill Lynch, Pierce, Fenner & Smith Incorporated (“Merrill Lynch”). 
 This Agreement is made pursuant to the Purchase
Agreement (the “Purchase Agreement”), dated November 21, 2006, between the Company and Merrill Lynch, which provides for the sale by the Company to Merrill Lynch of $125,000,000 aggregate principal amount (or $150,000,000 aggregate
principal amount if Merrill Lynch exercises its over-allotment option in full) of the Company’s 3.50% Convertible Senior Subordinated Notes due 2011 (the “Notes” and together with the American Depositary Shares (“ADSs”) of
the Company, each of which represents ten of the Company’s ordinary shares, par value $0.10 per share (“Ordinary Shares”), into which the Notes are convertible, the “Securities”). In order to induce Merrill Lynch to enter
into the Purchase Agreement, the Company has agreed to provide to Merrill Lynch and its direct and indirect transferees the registration rights set forth in this Agreement. The execution of this Agreement is a condition to the closing under the
Purchase Agreement. 
 In consideration of the foregoing, the parties hereto agree as follows: 
 1. Definitions. 
 As used in this
Agreement, the following capitalized defined terms shall have the following meanings: 
 “1933 Act” shall
mean the Securities Act of 1933, as amended from time to time. 
 “1934 Act” shall mean the Securities
Exchange Act of l934, as amended from time to time. 
 “1939 Act” shall mean the Trust Indenture Act of 1939,
as amended from time to time. 
 “Additional Interest” shall have the meaning set forth in Section 2.4
herein. 
 “ADSs” shall have the meaning set forth in the preamble. 
 “Automatic Shelf Registration Statement” shall have the meaning set forth in Rule 405 of the 1933 Act. 
 “Business Day” shall mean any weekday that is not a day on which banking institutions in The City of New York are
authorized or obligated to close. 
 “Closing Date” shall mean the Initial Closing Time as defined in the
Purchase Agreement. 

 “Company” shall have the meaning set forth in the preamble and shall
also include the Company’s successors. 
 “Depositary” shall mean Citibank, N.A., or any other
depositary appointed by the Company, provided, however, that such depositary must have an address in the Borough of Manhattan, in the City of New York. 
 “Effectiveness Period” shall have the meaning set forth in Section 2.1(b) herein. 
 “Holder” shall mean Merrill Lynch, for so long as it owns any Registrable Securities, and its successors, assigns and
direct and indirect transferees who become registered owners of Registrable Securities under the Indenture. 
 “Indenture” shall mean the Indenture relating to the Securities, dated as of the date hereof, between the Company and Wilmington Trust Company, as Trustee, as the same may be amended, supplemented, waived or otherwise
modified from time to time in accordance with the terms thereof. 
 “Issuer Free Writing Prospectus” shall
have the meaning set forth in Section 2.1(f) herein. 
 “Majority Holders” shall mean the Holders of a
majority of the aggregate principal amount of outstanding Registrable Securities; provided that, for purposes of this definition, (1) a Holder of ADSs that constitutes Registrable Securities which were issued upon conversion of the Notes
shall be deemed to hold an aggregate principal amount at maturity of Registrable Securities (in addition to the principal amount at maturity of any Registrable Securities held by such Holder) equal to the principal amount at maturity of Registrable
Securities which were converted into such ADSs and (2) such Registrable Securities which were converted into such ADSs shall be deemed to be outstanding; provided further, that whenever the consent or approval of Holders of a specified
percentage of Registrable Securities is required hereunder, Registrable Securities held by the Company or any Affiliate (as defined in the Indenture) of the Company shall be disregarded in determining whether such consent or approval was given by
the Holders of such required percentage amount. 
 “Merrill Lynch” shall have the meaning set forth in the
preamble. 
 “Offering Memorandum” shall mean the offering memorandum of the Company, dated November 15,
2006, related to the Securities. 
 “Ordinary Shares” shall have the meaning set forth in the preamble.

 “Person” shall mean an individual, partnership (general or limited), corporation, limited liability
company, trust or unincorporated organization, or a government or agency or political subdivision thereof. 
 “Prospectus” shall mean the prospectus relating to the Securities included in a Shelf Registration Statement, including any preliminary prospectus, and any such 
  

 2 

 prospectus as amended or supplemented by any prospectus supplement, including any such prospectus
supplement with respect to the terms of the offering of any portion of the Registrable Securities covered by a Shelf Registration Statement, and by all other amendments and supplements to a prospectus, including post-effective amendments, and in
each case including all materials incorporated by reference therein. 
 “Purchase Agreement” shall have the
meaning set forth in the preamble. 
 “Questionnaire” shall have the meaning set forth in Section 2.1(d)
herein. 
 “Registrable Securities” shall mean all or any of the Securities; provided, however,
that any such Securities shall cease to be Registrable Securities when (i) a Shelf Registration Statement with respect to such Securities shall have been declared effective under the 1933 Act and such Securities shall have been disposed of
pursuant to such Shelf Registration Statement, (ii) such Securities have been sold to the public pursuant to Rule 144 or may be sold or transferred pursuant to Rule l44(k) (or any similar provision then in force, but not Rule 144A) under the
1933 Act, or (iii) such Securities shall have ceased to be outstanding. 
 “Registration Default” shall
have the meaning set forth in Section 2.4 herein. 
 “Registration Expenses” shall mean any and all
expenses incident to performance of or compliance by the Company with this Agreement, whether or not a Shelf Registration Statement becomes effective, including without limitation: (i) all SEC, stock exchange or National Association of
Securities Dealers, Inc. (the “NASD”) registration and filing fees, including, if applicable, the reasonable and documented fees and expenses of any “qualified independent underwriter” (and its counsel) that is required to
be retained by any holder of Registrable Securities in accordance with the rules and regulations of the NASD, (ii) all fees and expenses incurred by the Company in connection with compliance with state securities or blue sky laws and compliance
with the rules of the NASD (including reasonable and documented fees and disbursements of counsel for any underwriters or Holders in connection with blue sky qualification of any of the Registrable Securities and any filings with the NASD),
(iii) all expenses of the Company in preparing or assisting in preparing, word processing, printing and distributing any Shelf Registration Statement, any Prospectus, any amendments or supplements thereto, any securities sales agreements and
other documents relating to the performance of and compliance with this Agreement, (iv) all fees and expenses incurred by the Company in connection with the listing, if any, of any of the Registrable Securities on any securities exchange or
exchanges, (v) all rating agency fees incurred by the Company, if any, (vi) the fees and disbursements of counsel for the Company and of the independent public accountants of the Company, including the expenses of any special audits or
“comfort” letters required by or incident to such performance and compliance, (vii) the reasonable and documented fees and expenses of the Trustee, and any escrow agent or custodian, and (viii) any fees and expenses of any
special experts retained by the Company in connection with any Shelf Registration Statement, but excluding any underwriting discounts and commissions and transfer taxes, if any, relating to the sale or disposition of Registrable Securities by a
Holder and the fees and expenses of any counsel and other professionals to the Holders, except as provided for in clause (viii) above. 
  

 3 

 “SEC” shall mean the Securities and Exchange Commission or any successor
agency or government body performing the functions currently performed by the United States Securities and Exchange Commission. 
 “Shelf Registration” shall mean a registration effected pursuant to Section 2.1 hereof. 
 “Shelf Registration Statement” shall mean a “shelf” registration statement of the Company pursuant to the provisions of Section 2.1 of this Agreement which covers all of the Registrable Securities on an
appropriate form under Rule 415 under the 1933 Act, or any similar rule that may be adopted by the SEC, and all amendments and supplements to such registration statement, including post-effective amendments, in each case including the Prospectus
contained therein, all exhibits thereto and all materials incorporated by reference therein. 
 “Suspension
Period” shall have the meaning set forth in Section 2.5 herein. 
 “Trustee” shall mean the
trustee with respect to the Securities under the Indenture. 
 “Well-Known Seasoned Issuer” shall have the
meaning set forth in Rule 405 of the 1933 Act. 
 2. Registration Under the 1933 Act. 
 2.1 Shelf Registration. 
 (a) The
Company shall, at its cost, no later than 120 days after the Closing Date, file with the SEC, and thereafter shall use its commercially reasonable efforts to cause to be declared effective as promptly as practicable but no later than 210 days after
the Closing Date, a Shelf Registration Statement relating to the offer and sale of the Registrable Securities by the Holders that have provided the information pursuant to Section 2.1(d). If the Company is a Well-Known Seasoned Issuer at the
time of filing the Shelf Registration Statement with the SEC, such Shelf Registration Statement shall be designated by the Company as an Automatic Shelf Registration Statement. 
 (b) The Company shall, at its cost, use its commercially reasonable efforts, subject to Section 2.5, to keep the Shelf Registration Statement
continuously effective in order to permit the Prospectus forming part thereof to be usable by Holders (i) for a period of two years from the date the Shelf Registration Statement is declared effective by the SEC, or (ii) for such shorter
period that will terminate (A) when all Registrable Securities covered by the Shelf Registration Statement have been sold pursuant to the Shelf Registration Statement, (B) when the Holders, other than “affiliates” (as defined in
Rule 144 under the 1933 Act) of the Company, are able to sell or transfer to the public all Registrable Securities immediately without restriction pursuant to Rule 144 (or any similar provision then in force, including Rule 144(k) but not Rule 144A)
under the 1933 Act or (C) when all Registrable Securities cease to be outstanding or otherwise cease to be Registrable Securities (the “Effectiveness Period”). 
  

 4 

 (c) Notwithstanding any other provisions hereof, the Company shall use its commercially reasonable
efforts to provide that (i) any Shelf Registration Statement and any amendment thereto and any Prospectus forming part thereof and any supplement thereto complies in all material respects with the 1933 Act and the rules and regulations
thereunder, (ii) any Shelf Registration Statement and any amendment thereto does not, when it becomes effective, contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make
the statements therein not misleading and (iii) any Prospectus forming part of any Shelf Registration Statement, and any supplement to such Prospectus (as amended or supplemented from time to time), does not include an untrue statement of a
material fact or omit to state a material fact necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. 
 (d) Notwithstanding any other provision hereof, no Holder of Registrable Securities may include any of its Registrable Securities in the Shelf
Registration Statement pursuant to this Agreement unless the Holder furnishes to the Company a fully completed notice and questionnaire in the form attached as Annex A to the Offering Memorandum (the “Questionnaire”) and such other
information in writing as the Company may reasonably request in writing for use in connection with the Shelf Registration Statement or Prospectus included therein and in any application to be filed with or under state securities laws. At least 30
days prior to the filing of the Shelf Registration Statement, the Company will provide notice to the Holders of its intention to file the Shelf Registration Statement. In order to be named as a selling securityholder in the Prospectus at the time of
effectiveness of the Shelf Registration Statement, each Holder must, before the filing of the Shelf Registration Statement and no later than the 20th day after being notified of the Company’s intention to file, furnish the completed
Questionnaire and such other information that the Company may reasonably request in writing, if any, to the Company in writing and the Company shall include the information from the completed Questionnaire and such other information, if any, in the
Shelf Registration Statement and the Prospectus in a manner so that upon effectiveness of the Shelf Registration Statement the Holder will be permitted to deliver the Prospectus to purchasers of the Holder’s Registrable Securities. From and
after the date that the Shelf Registration Statement is first declared effective by the SEC, upon receipt of a completed Questionnaire and such other information that the Company may reasonably request in writing, if any, the Company will use its
commercially reasonable efforts to file any amendments or supplements to the Shelf Registration Statement necessary for such Holder to be named as a selling securityholder in the Prospectus contained therein to permit such Holder to deliver the
Prospectus to purchasers of the Holder’s Securities (subject to the Company’s right to suspend the Shelf Registration Statement as described in Section 2.5 below); provided, however, that the Company shall not be
required to file more than one such amendment to the Shelf Registration Statement in any calendar quarter for all such Holders. Holders that do not deliver a completed written Questionnaire and such other information, as provided for in this
Section 2.1(d), will not be named as selling securityholders in the Prospectus. Each Holder named as a selling securityholder in the Prospectus agrees to promptly furnish to the Company in writing all information required to be disclosed in
order to make information previously furnished to the Company by the Holder not materially misleading and any other information regarding such Holder and the distribution of such Holder’s Registrable Securities as the Company may from time to
time reasonably request in writing. 
  

 5 

 (e) Each Holder agrees that if such Holder wishes to sell Registrable Securities pursuant to a Shelf
Registration Statement and related Prospectus it will do so only in accordance with Section 2.1(d) and subject to Section 2.5. Each Holder agrees not to sell any Registrable Securities pursuant to the Shelf Registration Statement without
delivering, or causing to be delivered, a Prospectus to the purchaser thereof and, following termination of the Effectiveness Period, to notify the Company, within ten days of a written request by the Company, of the amount of Registrable Securities
sold pursuant to the Shelf Registration Statement and, in the absence of a response within such period, the Company may assume that all of such Holder’s Registrable Securities have been so sold; provided that the Company shall use reasonable
efforts to confirm that all of such Holder’s Registrable Securities have been so sold prior to making such assumption. 
 (f) The
Company agrees that it will not, unless it obtains the prior consent of the Holders of a majority of the Registrable Securities that are registered under the Shelf Registration Statement at such time or the consent of the managing underwriter in
connection with any underwritten offering of Registrable Securities, and each Holder agrees that it will not, unless it obtains the prior written consent of the Company and any such underwriter, make any offer relating to the Securities that would
constitute, as the case may be, an “issuer free writing prospectus,” as defined in Rule 433 under the 1933 Act (an “Issuer Free Writing Prospectus”), or a “free writing prospectus,” as defined in Rule 405 under
the 1933 Act, required to be filed with the SEC. The Company represents that any Issuer Free Writing Prospectus will not include any information that conflicts with the information contained in the Shelf Registration Statement or Prospectus and that
any Issuer Free Writing Prospectus, when taken together with the information in the Shelf Registration Statement and the Prospectus, will not include any untrue statement of a material fact or omit to state any material fact necessary in order to
make the statements therein, in light of the circumstances under which they were made, not misleading. 
 The Company agrees to supplement or
amend the Shelf Registration Statement if required by the rules, regulations or instructions applicable to the registration form used by the Company if required by the 1933 Act, or to the extent the Company does not reasonably object, as reasonably
requested in writing by Merrill Lynch with respect to information relating to Merrill Lynch or by the Trustee on behalf of the Holders with respect to information relating to the Holders, and to furnish to the Holders of Registrable Securities that
are covered under such Shelf Registration Statement copies of any such supplement or amendment promptly after its being used or filed with the SEC in such amounts as they may reasonably request. 
 2.2 Expenses. The Company shall pay all Registration Expenses in connection with the registration pursuant to Section 2.1. Each Holder shall
pay all underwriting discounts and commissions, agency fees, brokers commissions and transfer taxes, if any, relating to the sale or disposition of such Holder’s Registrable Securities pursuant to the Shelf Registration Statement. 

 

 6 

 2.3 Effectiveness. (a) The Company will be deemed not to have used its commercially
reasonable efforts to cause the Shelf Registration Statement to become, or to remain, effective during the requisite period (subject to Section 2.5) if the Company voluntarily takes any action that would, or omits to take any action which
omission would, result in any such Shelf Registration Statement not being declared effective or in the Holders of Registrable Securities covered thereby not being able to offer and sell such Registrable Securities during that period as and to the
extent contemplated hereby, unless such action is required by applicable law. 
 (b) A Shelf Registration Statement pursuant to
Section 2.1 hereof will not be deemed to have become effective unless it has been declared effective by the SEC or have become automatically effective under the 1933 Act; provided, however, that if, after it has been declared
effective, the offering of Registrable Securities pursuant to a Shelf Registration Statement is interfered with by any stop order, injunction or other order or requirement of the SEC or any other governmental agency or court, such Shelf Registration
Statement will be deemed not to have become effective during the period of such interference, until the offering of Registrable Securities pursuant to such Shelf Registration Statement may legally resume. 
 2.4 Interest. In the event that (a) a Shelf Registration Statement is not filed with the SEC on or before the 120th calendar day following the Closing Date, (b) a Shelf Registration Statement is not declared effective on or prior to the
210th calendar day following the Closing Date, (c) after effectiveness, subject to Section 2.5, the Shelf
Registration Statement ceases to be effective or fails to be usable by the Holders without being succeeded within seven Business Days by a post-effective amendment or a report filed with the SEC pursuant to the 1934 Act that cures the failure to be
effective or usable, or (d) the Prospectus is unusable by the Holders for any reason, and the number of days for which the Shelf Registration Statement shall not be usable exceeds the Suspension Period (as defined in Section 2.5 hereof)
(each such event being a “Registration Default”), additional interest (“Additional Interest”) will accrue at a rate per annum of one-quarter of one percent (0.25%) of the principal amount of the Notes then
outstanding for the first 90-day period from the day following the Registration Default, and thereafter at a rate per annum of one-half of one percent (0.50%) of the principal amount of the Notes then outstanding; provided that in no event
shall Additional Interest accrue at a rate per annum exceeding one half of one percent (0.50%) of the principal amount of the Notes then outstanding; provided further that no Additional Interest shall accrue after the second anniversary of
the Closing Date; provided further that Additional Interest shall not accrue under clauses (a), (b) and (c) above with respect to any Holder that (x) does not submit a properly completed Questionnaire and other information, if
any, requested pursuant to Section 2.1(d) above, and (y) is not named as a selling securityholder in the Shelf Registration Statement. Notwithstanding the foregoing, in no event will Additional Interest be payable in connection with a
failure to register the ADSs into which the Notes are convertible; for the avoidance of doubt, if none of the Securities are registered, then Additional Interest will only be payable in connection with the Registration Default relating to the
failure to register the Notes. Upon the cure of all Registration Defaults then continuing, the accrual of Additional Interest will automatically cease and the interest rate borne by the Securities will revert to the original interest rate at such
time. Additional Interest shall be computed based on the actual number of days elapsed in each 90-day period in which the Shelf Registration Statement or the Prospectus is not effective or is unusable. Holders who have converted Securities into ADSs
will not be entitled to receive any Additional Interest with respect to such ADSs or the principal amount of the Notes converted. 
  

 7 

 The Company shall notify the Trustee within five Business Days after each and every date on which an
event occurs in respect of which Additional Interest is required to be paid. Additional Interest shall be paid by depositing with the Trustee, in trust, for the benefit of the Holders of Registrable Securities, on or before the applicable semiannual
interest payment date, in immediately available funds in sums sufficient to pay the Additional Interest then due. The Additional Interest due shall be payable in arrears on each interest payment date to the record Holder of Registrable Securities
entitled to receive the interest payment to be paid on such date as set forth in the Indenture. Each obligation to pay Additional Interest shall be deemed to accrue from and including the day following the Registration Default to but excluding the
day on which the Registration Default is cured. 
 A Registration Default under clause (a) above shall be cured on the date that the
Registration Statement is filed with the SEC. A Registration Default under clause (b) above shall be cured on the date that the Shelf Registration Statement is declared effective by the SEC or deemed to become automatically effective under the
1933 Act. A Registration Default under clauses (c) or (d) above shall be cured on the date an amended Shelf Registration Statement is declared effective by the SEC or deemed to become automatically effective under the 1933 Act, or the
Company otherwise declares the Shelf Registration Statement and the Prospectus useable, as applicable. The Company will have no liabilities for monetary damages other than the Additional Interest with respect to any Registration Default. 

2.5 Suspension. Notwithstanding any other provision hereof, the Company may suspend the use of any Prospectus, without incurring or accruing
any obligation to pay Additional Interest pursuant to Section 2.4 hereof or being deemed in violation of any other provision hereof, for a period not to exceed 90 consecutive calendar days or an aggregate of 120 calendar days in any
twelve-month period (each, a “Suspension Period”) if the Board of Directors of the Company shall have determined in good faith that because of valid business reasons (not including avoidance of the Company’s obligations
hereunder), including without limitation proposed or pending corporate developments and similar events or because of filings with the SEC, it is in the best interests of the Company to suspend such use, and prior to suspending such use the Company
provides the Holders with written notice of such suspension, which notice need not specify the nature of the event giving rise to such suspension (and, upon receipt of such notice, each Holder agrees in writing not to sell any Registrable Securities
pursuant to the Shelf Registration Statement until the earlier of (a) the date on which such Holder is advised in writing that the Prospectus may be used or (b) the expiration of the applicable 90-day or 120-day Suspension Period. Each
Holder shall keep confidential any communications received by it from the Company regarding the suspension of the use of the Prospectus (including, without limitation, the fact of the suspension), except as required by applicable law. 
 3. Registration Procedures. 
 In
connection with the obligations of the Company with respect to the Shelf Registration, the Company shall, subject to the rights of the Company to invoke and maintain a 
  

 8 

 Suspension Period in accordance with Section 2.5 without being in violation of any of the provisions hereunder:

 (a) prepare and file with the SEC a Shelf Registration Statement, within the relevant time period specified in Section 2, on the
appropriate form under the 1933 Act, which form (i) shall be selected by the Company, (ii) shall be available for the sale of the Registrable Securities by the selling Holders thereof, (iii) shall comply as to form in all material
respects with the requirements of the applicable form and include or incorporate by reference all financial statements required by the SEC to be filed therewith or incorporated by reference therein, and (iv) shall comply in all respects with
the applicable requirements of Regulation S-T under the 1933 Act, if any, and use commercially reasonable efforts to cause such Shelf Registration Statement to become effective and remain effective in accordance with Section 2 hereof;

 (b) prepare and file with the SEC such amendments and post-effective amendments to the Shelf Registration Statement as may be necessary
under applicable law to keep the Shelf Registration Statement effective for the Effectiveness Period, subject to Section 2.5; and cause each Prospectus to be supplemented by any required prospectus supplement, and as so supplemented to be filed
pursuant to Rule 424 (or any similar provision then in force) under the 1933 Act and use commercially reasonable efforts to comply during the Effectiveness Period with the provisions of the 1933 Act, the 1934 Act and the rules and regulations
thereunder required to enable the disposition of all Registrable Securities covered by the Shelf Registration Statement in accordance with the intended method or methods of distribution (as provided to the Company in the Questionnaire) by the
selling Holders thereof; 
 (c)(i) notify each Holder of Registrable Securities of the filing of a Shelf Registration Statement with
respect to the Registrable Securities; (ii) furnish to each Holder of Registrable Securities that has provided the information required by Section 2.1(d) and to each underwriter of an underwritten offering of Registrable Securities, if
any, without charge, electronic copies of each Prospectus, including each preliminary Prospectus, and any amendment or supplement thereto and such other documents as such Holder or underwriter may reasonably request in writing, including financial
statements and schedules and, if the Holder so requests, all exhibits in order to facilitate the unrestricted sale or other disposition of the Registrable Securities; and (iii) subject to Section 2.5 hereof and to any notice by the Company
in accordance with Section 3(e) hereof of the existence of any fact of the kind described in Sections 3(e)(ii), (iii), (iv), (v) and (vi) hereof, hereby consent to the use of the Prospectus or any amendment or supplement thereto by
each of the selling Holders of Registrable Securities that has provided the Questionnaire and the other information required by Section 2.1(d) in connection with the offering and sale of the Registrable Securities covered by such Prospectus or
any amendment or supplement thereto in the manner set forth therein; 
 (d) use commercially reasonable efforts to register or qualify the
Registrable Securities under all applicable state securities or “blue sky” laws of such jurisdictions as any Holder of Registrable Securities covered by a Shelf Registration Statement and each underwriter of an underwritten offering of
Registrable Securities shall reasonably request in writing, and do any and all other acts and things which may be reasonably necessary or advisable to enable each such Holder and underwriter to consummate the disposition in each 
  

 9 

 such jurisdiction of such Registrable Securities owned by such Holder; provided, however, that the Company
shall not be required to (i) qualify as a foreign corporation or as a dealer in securities in any jurisdiction where it would not otherwise be required to qualify but for this Section 3(d), or (ii) take any action which would subject
it to general service of process or taxation in any such jurisdiction where it is not then so subject; 
 (e) notify as promptly as
reasonably practicable each Holder of Registrable Securities under a Shelf Registration Statement that has provided the Questionnaire and the other information required by Section 2.1(d) promptly (i) when a Shelf Registration Statement has
become effective and when any post-effective amendments thereto have become effective, (ii) of any request by the SEC or any state securities authority for post-effective amendments and supplements to a Shelf Registration Statement and
Prospectus or for additional information relating thereto after the Shelf Registration Statement has become effective, (iii) of the issuance by the SEC or any state securities authority of any stop order suspending the effectiveness of a Shelf
Registration Statement or the initiation of any proceedings for that purpose, (iv) of the happening of any event or the discovery of any facts during the period a Shelf Registration Statement is effective which makes any statement made in such
Shelf Registration Statement or the related Prospectus untrue in any material respect or which requires the making of any changes in such Shelf Registration Statement or Prospectus in order to make the statements therein (in the case of the
Prospectus in light of the circumstances under which they were made) not misleading (provided, however, that no notice by the Company shall be required pursuant to this clause (iv) in the event that the Company either promptly files a
Prospectus supplement to update the Prospectus or other appropriate 1934 Act report that is incorporated by reference into the Shelf Registration Statement, which, in either case, contains the requisite information that results in such Shelf
Registration Statement no longer containing any untrue statement of material fact or omitting to state a material fact necessary to make the statements therein not misleading, (v) of the receipt by the Company of any notification with respect
to the suspension of the qualification of the Registrable Securities for sale in any jurisdiction or the initiation or threatening of any proceeding for such purpose and (vi) of any determination by the Company that a post-effective amendment
to such Shelf Registration Statement would be appropriate, other than a post-effective amendment solely to add selling Holders; 
 (f)
furnish to Merrill Lynch on behalf of the Holders of Registrable Securities and to one special counsel to Merrill Lynch (i) copies of any comment letters received from the SEC with respect to a Shelf Registration Statement, and, if requested,
with respect to any documents incorporated therein and (ii) any other request by the SEC or any state securities authority for amendments or supplements to a Shelf Registration Statement and Prospectus or for additional information with respect
to the Shelf Registration Statement and Prospectus; 
 (g) use commercially reasonable efforts to obtain the withdrawal of any order
suspending the effectiveness of a Shelf Registration Statement at the earliest practicable moment or, if any such order or suspension is made effective during any Suspension Period, at the earliest practicable moment after the Suspension Period, and
provide prompt notice to each Holder of the withdrawal of such order; 
  

 10 

 (h) furnish to each Holder of Registrable Securities that has provided the information required by
Section 2.1(d), and each underwriter, if any, without charge, at least one conformed copy of each Shelf Registration Statement and any post-effective amendment thereto, including financial statements and schedules (without documents
incorporated therein by reference and all exhibits thereto, unless requested); 
 (i) if electronic global certificates for the Registrable
Securities are not then available, cooperate with the selling Holders of Registrable Securities to facilitate the timely preparation and delivery of certificates representing Registrable Securities to be sold and not bearing any restrictive legends
(other than as required by applicable law); and enable such Registrable Securities to be in such denominations (consistent with the provisions of the Indenture) and registered in such names as the selling Holders or the underwriters, if any, may
reasonably request at least three Business Days prior to the closing of any sale of Registrable Securities; 
 (j) upon the occurrence of
any event or the discovery of any facts, each as contemplated by Sections 3(e)(ii), (iii), (iv), (v) and (vi) hereof, as promptly as practicable after the occurrence of such an event, use commercially reasonable efforts to prepare a
supplement or post-effective amendment to the Shelf Registration Statement or the related Prospectus or any document incorporated therein by reference or file any other required document so that, as thereafter delivered to the purchasers of the
Registrable Securities, such Prospectus will not contain at the time of such delivery any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in light of the circumstances under which they
were made, not misleading or will remain so qualified. At such time as such public disclosure is otherwise made or the Company determines that such disclosure is not necessary, in each case to correct any misstatement of a material fact or to
include any omitted material fact, the Company agrees promptly to notify each Holder that has provided the Questionnaire and the other information required by Section 2.1(d) of such determination and to furnish each Holder such number of copies
of the Prospectus as amended or supplemented, as such Holder may reasonably request; 
 (k) no less than three Business Days prior to the
filing of any Shelf Registration Statement, any Prospectus, any amendment to a Shelf Registration Statement or amendment or supplement to a Prospectus (other than amendments and supplements that do nothing more than name Holders and provide
information with respect thereto), provide copies of such document to Merrill Lynch on behalf of such Holders, and make representatives of the Company, as shall be reasonably requested by special counsel to the Holders of Registrable Securities or
Merrill Lynch on behalf of such Holders, available for discussion of such document; 
 (l) obtain CUSIP numbers for all Registrable
Securities not later than the effective date of the Shelf Registration Statement and provide the Trustee with printed certificates for the Registrable Securities in a form eligible for deposit with the Depositary; 
 (m)(i) cause the Indenture to be qualified under the 1939 Act in connection with the registration of the Registrable Securities, (ii) cooperate
with the Trustee and the Holders to effect such changes to the Indenture as may be required for the Indenture to be so 
  

 11 

 qualified in accordance with the terms of the 1939 Act, and (iii) execute, and use commercially reasonable efforts
to cause the Trustee to execute, all documents as may be required to effect such changes, and all other forms and documents required to be filed with the SEC to enable the Indenture to be so qualified in a timely manner; 
 (n) enter into such customary agreements (including, if requested, an underwriting agreement in customary form) and take all other customary and
appropriate actions, if any, as the Majority Holders shall reasonably request in writing in order to expedite or facilitate the disposition of such Registrable Securities, including, but not limited to: 
 (i) obtaining opinions of counsel to the Company and updates thereof addressed to each selling Holder and the underwriters, if any,
covering the matters set forth in the opinions of such counsel delivered at the Closing Date as are customarily covered in legal opinions in connection with underwritten offering of securities; 
 (ii) obtaining “comfort” letters and updates thereof from the Company’s independent certified public accountants (and, if
necessary, any other independent certified public accountants of the subsidiary of the Company or of any business acquired by the Company for which financial statements are, or are required to be, included in the Shelf Registration Statement)
addressed to the underwriters, if any, and use reasonable efforts to have such letter addressed to the selling Holders of Registrable Securities (to the extent consistent with Statement on Auditing Standards No. 72 of the American Institute of
Certified Public Accounts), such letters substantially in the form and covering the matters covered in the comfort letter delivered on the Closing Date; 
 (iii) if an underwriting agreement is entered into, causing the same to set forth indemnification provisions and procedures substantially equivalent to the indemnification provisions and procedures set forth in
Section 4 hereof with respect to the underwriters and all other parties to be indemnified pursuant to said Section or, at the request of any underwriters, in the form customarily provided to such underwriters in similar types of transactions;
and 
 (iv) delivering such documents and certificates as may be reasonably requested and as are customarily delivered in
similar offerings to the Holders of a majority in principal amount of the Registrable Securities being sold and the managing underwriters, if any. 
 The
above shall be done only in connection with any underwritten offering of Registrable Securities using such Shelf Registration Statement pursuant to an underwriting or similar agreement as and to the extent required thereunder, and as reasonably
requested by the Majority Holders thereto; provided, however, that in no event will an underwritten offering of Registrable Securities be made without the prior written agreement of the Company. The Company will not be required to pay the costs and
expenses of any professional advisors engaged by the underwriters thereof or the Holders in connection with the offering of the Registrable Securities. 
  

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 (o) if reasonably requested in connection with a disposition of Registrable Securities, make reasonably
available for inspection during business hours by representatives of the Holders of the Registrable Securities, any underwriters participating in any disposition pursuant to a Shelf Registration Statement and any counsel or accountant retained by
any of the foregoing, all relevant financial and other records, pertinent corporate documents and properties of the Company reasonably requested in writing by any such persons, and cause the respective officers, directors, employees, and any other
agents of the Company to make reasonably available for inspection during normal business hours all relevant information reasonably requested by any such representative, underwriter, special counsel or accountant in connection with a Shelf
Registration Statement, and make such representatives of the Company available for discussion of such documents as shall be reasonably requested by Merrill Lynch, in each case as is customary for “due diligence” investigations;
provided that, to the extent the Company, in its reasonable discretion, agrees to disclose material non-public information, such persons shall first agree in writing with the Company that any such non-public information shall be kept
confidential by such persons and shall be used solely for the purposes of exercising rights under this Agreement and such person shall not engage in trading any securities of the Company until such material non-public information becomes properly
publicly available, unless (i) disclosure of such information is required by court or administrative order or is necessary to respond to inquiries of regulatory authorities, (ii) disclosure of such information is required by law (including
any disclosure requirements pursuant to federal securities laws in connection with the filing of any Shelf Registration Statement or the use of any Prospectus referred to in this Agreement upon a customary opinion of counsel for such persons
delivered and reasonably satisfactory to the Company), (iii) such information becomes generally available to the public other than as a result of a disclosure or failure to safeguard by any such person, (iv) such information becomes
available to any such person from a source other than the Company and such source is not bound by a confidentiality agreement, or (v) such non-public information ceases to be material; provided further, that, the foregoing inspection and
information gathering shall, to the greatest extent possible, be coordinated on behalf of all the Holders and the other parties entitled thereto by special counsel to the Holders; 
 (p) if requested in writing by any selling Holder of Registrable Securities that has provided the information required by Section 2.1(d), a
reasonable time prior to filing the Shelf Registration Statement, any Prospectus forming a part thereof, any amendment to the Shelf Registration Statement or amendment or supplement to such Prospectus (other than amendments and supplements that do
nothing more than name Holders and provide information with respect thereto), (i) provide copies of such document to the Holders of Registrable Securities that have provided the information required by Section 2.1(d), to Merrill Lynch, to
special counsel for the Holders and to the underwriter or underwriters of an underwritten offering of Registrable Securities, if any, (ii) make such changes in any such document prior to the filing thereof as Merrill Lynch, the special counsel
to the Holders or the underwriter or underwriters reasonably agree should be included therein and provide to the Company in writing for inclusion therein within three business days of delivery of such copies, (iii) if requested by any selling
Holder of Registrable Securities that has provided the information required by Section 2.1(d), not file any such document in a form (A) to which the Majority Holders, Merrill Lynch on behalf of the Holders of Registrable Securities,
special counsel for the Holders of Registrable Securities or any underwriter shall not have previously been advised and furnished a copy of or (B) to which the Majority Holders, Merrill Lynch on behalf of the Holders of Registrable Securities,
special 
  

 13 

 counsel to the Holders of Registrable Securities or any underwriter shall reasonably object within three business days of
delivery of such copies, and (iv) make the representatives of the Company available for discussion of such document as shall be reasonably requested in writing by the Holders of Registrable Securities, Merrill Lynch on behalf of such Holders,
special counsel for the Holders of Registrable Securities or any underwriter; provided, however, that the foregoing discussion shall be coordinated on behalf of the parties entitled thereto by the special counsel to the Holders; 
 (q) if requested by any selling Holder or the underwriters, if any, incorporate in the Shelf Registration Statement or Prospectus, pursuant to a
supplement or post-effective amendment if necessary, such information as such selling Holder or underwriter, if any, may reasonable request in writing to have included therein with respect to the name or names of such selling Holder, the number of
shares of Common Stock or principal amount of Securities owned by such Holder, the plan of distribution of the Registrable Securities (as required by Item 508 of Regulation S-K), the principal amount of Securities or number of shares of Common
Stock being sold, the purchase price being paid therefor, and any other terms of the offering of the Registrable Securities to be sold in such offering; 
 (r) use commercially reasonable efforts to cause all Registrable Securities to be listed on any securities exchange or inter-dealer quotation system on which similar debt securities issued by the Company are then
listed if requested by the Majority Holders, or if requested by the underwriter or underwriters of an underwritten offering of Registrable Securities, if any; 
 (s) otherwise comply with all applicable rules and regulations of the SEC and make available to its security holders, as soon as reasonably practicable, an earnings statement covering at least 12 months (which are not
required to be audited) satisfying the provisions of Section 11(a) of the 1933 Act and Rule 158 thereunder; and 
 (t) cooperate and
assist in any filings required to be made with the NASD and in the performance of any due diligence investigation by any underwriter and its counsel (including any “qualified independent underwriter” that is required to be retained in
accordance with the rules and regulations of the NASD). 
 Without limiting the provisions of Section 2.1(d), the Company may (as a
condition to such Holder’s participation in the Shelf Registration) require each Holder of Registrable Securities to furnish to the Company such information regarding the Holder and the proposed distribution by such Holder of such Registrable
Securities as the Company may from time to time reasonably request in writing. Each Holder agrees promptly to furnish to the Company in writing all information required to be disclosed in order to make the information previously furnished to the
Company by such Holder not misleading, any other information regarding such Holder and the distribution of such Registrable Securities as may be required to be disclosed in the Prospectus or Shelf Registration Statement under applicable law or
pursuant to SEC comments and any information otherwise reasonably required by the Company to comply with applicable law or regulations. 
  

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 Each Holder agrees that, upon receipt of any notice from the Company of the happening of any event or the
discovery of any facts, each of the kind described in Section 3(e)(ii), (iii), (iv), (v) or (vi) hereof, such Holder will forthwith discontinue disposition of Registrable Securities pursuant to the Prospectus included in the Shelf
Registration Statement until such Holder’s receipt of the copies of the supplemented or amended Prospectus contemplated by Section 3(j) hereof or written notice from the Company that the Shelf Registration Statement is again effective and
no amendment or supplement is needed, and, if so directed by the Company, such Holder will deliver to the Company (at its expense) all copies in such Holder’s possession, other than permanent file copies then in such Holder’s possession,
of the Prospectus covering such Registrable Securities current at the time of receipt of such notice. 
 If any of the Registrable Securities
covered by any Shelf Registration Statement are to be sold in an underwritten offering, the underwriter or underwriters and manager or managers that will manage such offering will be selected by the Majority Holders of such Registrable Securities
included in such offering and shall be acceptable to the Company. No Holder of Registrable Securities may participate in any underwritten registration hereunder unless such Holder (a) agrees to sell such Holder’s Registrable Securities on
the basis provided in any underwriting arrangements approved by the persons entitled hereunder to approve such arrangements and (b) completes and executes all questionnaires, powers of attorney, indemnities, underwriting agreements and other
documents required under the terms of such underwriting arrangements. 
 4. Indemnification; Contribution. 
 (a) The Company agrees to indemnify and hold harmless Merrill Lynch, each Holder, each Person who participates as an underwriter, if any (any such Person
being an “Underwriter”) and each Person, if any, who controls any such Holder or Underwriter within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act as follows: 
 (i) against any and all loss, liability, claim, damage and expense whatsoever, as incurred, arising out of any untrue statement or
alleged untrue statement of a material fact contained in any Shelf Registration Statement (or any amendment or supplement thereto) pursuant to which Registrable Securities were registered under the 1933 Act, including all documents incorporated
therein by reference, or the omission or alleged omission therefrom of a material fact required to be stated therein or necessary to make the statements therein not misleading, or arising out of any untrue statement or alleged untrue statement of a
material fact contained in any Prospectus (or any amendment or supplement thereto) or any Issuer Free Writing Prospectus (or any amendment or supplement thereto) or the omission or alleged omission therefrom of a material fact necessary in order to
make the statements therein, in the light of the circumstances under which they were made, not misleading; 
 (ii) against
any and all loss, liability, claim, damage and expense whatsoever, as incurred, to the extent of the aggregate amount paid in settlement of any litigation, or any investigation or proceeding by any governmental agency or body, commenced or
threatened, or of any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission; provided that (subject to Section 4(d) below) any such settlement is effected with the written
consent of the Company; and 
  

 15 

 (iii) against any and all expense whatsoever, as incurred (including the reasonable and
documented fees and disbursements of counsel chosen by any indemnified party), reasonably incurred and documented in investigating, preparing or defending against any litigation, or any investigation or proceeding by any governmental agency or body,
commenced or threatened, or any claim whatsoever based upon any such untrue statement or omission, or any such alleged untrue statement or omission, to the extent that any such expense is not paid under subparagraph (i) or (ii) above;

 provided, however, that this indemnity agreement shall not apply to any loss, liability, claim, damage or expense to the extent arising out
of (A) any untrue statement or omission or alleged untrue statement or omission made in reliance upon and in conformity with written information furnished to the Company by or on behalf of any Holder or Underwriter, if any, expressly for use in
a Shelf Registration Statement (or any amendment thereto), any Prospectus (or any amendment or supplement thereto) or any Issuer Free Writing Prospectus (or any amendment or supplement thereto), (B) use of a Prospectus during a period when use
of such Prospectus has been validly suspended pursuant to Section 2.5 hereof, provided that such Holder has received prior notice of such suspension or (C) failure of such Holder to deliver a prospectus, as then amended or supplemented, as
required by applicable laws, provided that the Company shall have delivered to such Holder such Prospectus, as then amended or supplemented. 
 (b) Each Holder, severally, but not jointly, agrees to indemnify and hold harmless the Company, Merrill Lynch, each Underwriter, if any, and the other selling Holders, and each of their respective directors and officers, and each Person, if
any, who controls the Company, Merrill Lynch, any Underwriter or any other selling Holder within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act, against any and all loss, liability, claim, damage and expense
described in the indemnity contained in Section 4(a) hereof, as incurred and documented, but only with respect to untrue statements or omissions, or alleged untrue statements or omissions, made in the Shelf Registration Statement (or any
amendment thereto) or any Prospectus included therein (or any amendment or supplement thereto) or any Issuer Free Writing Prospectus in reliance upon and in conformity with written information with respect to such Holder furnished to the Company by
or on behalf of such Holder expressly for use in the Shelf Registration Statement (or any amendment thereto) or such Prospectus (or any amendment or supplement thereto) or any Issuer Free Writing Prospectus; provided, however, that no
such Holder shall be liable for any claims hereunder in excess of the amount of net proceeds received by such Holder from the sale of Registrable Securities pursuant to such Shelf Registration Statement. 
 (c) Each indemnified party shall give notice as promptly as reasonably practicable to each indemnifying party of any action or proceeding commenced
against it in respect of which indemnity may be sought hereunder, but failure to so notify an indemnifying party shall not relieve such indemnifying party from any liability hereunder to the extent it is not materially prejudiced as a result thereof
and in any event shall not relieve it from any liability which it may have otherwise than on account of this indemnity agreement. An indemnifying 
  

 16 

 party may participate at its own expense in the defense of such action; provided, however, that counsel to
the indemnifying party shall not (except with the consent of the indemnified party) also be counsel to the indemnified party. In no event shall the indemnifying party or parties be liable for the reasonable and documented fees and expenses of more
than one counsel (in addition to any local counsel) separate from their own counsel for all indemnified parties in connection with any one action or separate but similar or related actions in the same jurisdiction arising out of the same general
allegations or circumstances. No indemnifying party shall (i) without the prior written consent of the indemnified parties (which consent shall not be unreasonably withheld), settle or compromise or consent to the entry of any judgment with
respect to any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever in respect of which indemnification or contribution could be sought under this Section 4 (whether
or not the indemnified parties are actual or potential parties thereto), unless such settlement, compromise or consent (A) includes an unconditional release of each indemnified party from all liability arising out of such litigation,
investigation, proceeding or claim and (B) does not include a statement as to or an admission of fault, culpability or a failure to act by or on behalf of any indemnified party or (ii) be liable for any settlement of any such action
effected without its prior written consent (which consent shall not be unreasonably withheld). 
 (d) Notwithstanding clause (ii) of
Section 4(c), if at any time an indemnified party shall have requested an indemnifying party to reimburse the indemnified party for fees and expenses of counsel, such indemnifying party agrees that it shall be liable for any settlement of the
nature contemplated by Section 4(a)(ii) effected without its written consent if (i) such settlement is entered into more than 45 days after receipt by such indemnifying party of the aforesaid request, (ii) such indemnifying party
shall have received notice of the terms of such settlement at least 30 days prior to such settlement being entered into and (iii) such indemnifying party shall not have reimbursed such indemnified party in accordance with such request prior to
the date of such settlement. 
 (e) If the indemnification provided for in this Section 4 is for any reason unavailable to or
insufficient to hold harmless an indemnified party in respect of any losses, liabilities, claims, damages or expenses referred to therein, then each indemnifying party shall contribute to the aggregate amount of such losses, liabilities, claims,
damages and expenses incurred by such indemnified party, as incurred, in such proportion as is appropriate to reflect the relative fault of the Company on the one hand and the Holders and Merrill Lynch on the other hand in connection with the
statements or omissions which resulted in such losses, liabilities, claims, damages or expenses, as well as any other relevant equitable considerations. 
 The relative fault of the Company on the one hand and the Holders and Merrill Lynch on the other hand shall be determined by reference to, among other things, whether any such untrue or alleged untrue statement of a
material fact or omission or alleged omission to state a material fact relates to information supplied by the Company, or by the Holders or Merrill Lynch and the parties’ relative intent, knowledge, access to information and opportunity to
correct or prevent such statement or omission. 
 The Company, the Holders and Merrill Lynch agree that it would not be just and equitable if
contribution pursuant to this Section 4 were determined by pro rata allocation or by 
  

 17 

 any other method of allocation which does not take account of the equitable considerations referred to above in this
Section 4. The aggregate amount of losses, liabilities, claims, damages and expenses incurred and documented by an indemnified party and referred to above in this Section 4 shall be deemed to include any legal or other expenses reasonably
incurred by such indemnified party in investigating, preparing or defending against any litigation, or any investigation or proceeding by any governmental agency or body, commenced or threatened, or any claim whatsoever based upon any such untrue or
alleged untrue statement or omission or alleged omission. 
 Notwithstanding the provisions of this Section 4, Merrill Lynch shall not
be required to contribute any amount in excess of the amount by which the total price at which the Securities sold by it were offered exceeds the amount of any damages which Merrill Lynch has otherwise been required to pay by reason of such untrue
or alleged untrue statement or omission or alleged omission. 
 No Person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the 1933 Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. 
 For purposes of this Section 4, each Person, if any, who controls Merrill Lynch or Holder within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act shall have the same rights to contribution as Merrill
Lynch or Holder, and each director of the Company, and each Person, if any, who controls the Company within the meaning of Section 15 of the 1933 Act or Section 20 of the 1934 Act shall have the same rights to contribution as the Company.
The obligations of the Company, Merrill Lynch and the Holders pursuant to this Section 4 shall be in addition to any liability that such party may otherwise have. 
 5. Miscellaneous. 
 5.1 Rule 144 and Rule 144A. For so long as the Company is subject to the
reporting requirements of Section 13 or 15(d) of the 1934 Act, the Company covenants that it will file the reports required to be filed by it under Section 13 of 15(d) of the 1934 Act and the rules and regulations adopted by the SEC
thereunder. If the Company ceases to be so required to file such reports, the Company covenants that it will upon the request of any Holder of Registrable Securities (a) make publicly available such information as is necessary to permit sales
pursuant to Rule 144 under the 1933 Act, (b) deliver such information to a prospective purchaser as is necessary to permit sales pursuant to Rule 144A under the 1933 Act and it will take such further action as any Holder of Registrable
Securities may reasonably request for such purpose, and (c) take such further action that is reasonable in the circumstances, in each case, to the extent required from time to time to enable such Holder to sell its Registrable Securities
without registration under the 1933 Act within the limitation of the exemptions provided by (i) Rule 144 under the 1933 Act, as such Rule may be amended from time to time, (ii) Rule 144A under the 1933 Act, as such Rule may be amended from
time to time, or (iii) any similar rules or regulations hereafter adopted by the SEC. Upon the request of any Holder of Registrable Securities, the Company will deliver to such Holder a written statement as to whether it has complied with such
requirements. 
  

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 5.2 No Inconsistent Agreements. The Company has not entered into and the Company shall not, after
the date of this Agreement, enter into any agreement which is inconsistent with the rights granted to the Holders of Registrable Securities in this Agreement or otherwise conflicts with the provisions hereof. The rights granted to the Holders
hereunder do not and will not for the term of this Agreement in any way conflict with the rights granted to the holders of any of the Company’s other issued and outstanding securities under any such agreements. 
 5.3 No Adverse Actions Affecting Registration Rights. Subject to the rights of the Company to invoke and maintain a Suspension Period, the Company
shall not, directly or indirectly, intentionally take any action with respect to the Registrable Securities as a class that would adversely affect the ability of the Holders of Registrable Securities to include such Registrable Securities in a
registration undertaken pursuant to this Agreement. 
 5.4 Amendments and Waivers. The provisions of this Agreement, including the
provisions of this sentence, may not be amended, modified or supplemented, and waivers or consents to departures from the provisions hereof may not be given unless the Company has obtained the written consent of Holders of at least a majority in
aggregate principal amount of the outstanding Registrable Securities (with Holders of Securities deemed to be the Holders, for purposes of this Section 5.4, of the number of outstanding shares of Common Stock into which such Registrable
Securities are or could be convertible on the date that consent would be required) affected by such amendment, modification, supplement, waiver or departure. Notwithstanding the foregoing, this Agreement may be amended by a written agreement between
the Company and Merrill Lynch, without the consent of the Holders of the Registrable Securities, in order to cure any ambiguity or to correct or supplement any provision contained herein, provided that no such amendment shall adversely affect the
interest of the Holders of Registrable Securities. Each Holder of Registrable Securities outstanding at the time of any amendment, modification, waiver or consent pursuant to this Section 5.4, shall be bound by such amendment, modification,
waiver or consent, whether or not any notice or writing indicating such amendment, modification, waiver or consent is delivered to such Holder. 
 5.5 Notices. All notices and other communications provided for or permitted hereunder shall be made in writing by hand delivery, registered first-class mail, facsimile, or any courier guaranteeing overnight delivery (a) if to a
Holder, at the most current address given by such Holder to the Company in a Questionnaire or by means of a notice given in accordance with the provisions of this Section 5.5, which address initially is the address set forth in the Purchase
Agreement with respect to Merrill Lynch; and (b) if to the Company, initially at the Company’s address set forth in the Purchase Agreement, and thereafter at such other address of which notice is given in accordance with the provisions of
this Section 5.5. 
 All such notices and communications shall be deemed to have been duly given: at the time delivered by hand, if
personally delivered; two Business Days after being deposited in the mail, postage prepaid, if mailed; when receipt is acknowledged, if sent by facsimile; and on the next Business Day if timely delivered to an overnight courier. 
  

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 Copies of all such notices, demands, or other communications shall be concurrently delivered by the
person giving the same to the Trustee under the Indenture, at the address specified in such Indenture. 
 5.6 Successors and Assigns.
This Agreement shall inure to the benefit of and be binding upon the successors, assigns and transferees of each of the parties, including, without limitation and without the need for an express assignment, subsequent Holders; provided that
nothing herein shall be deemed to permit any assignment, transfer or other disposition of Registrable Securities in violation of the terms of the Purchase Agreement or the Indenture. If any transferee of any Holder shall acquire Registrable
Securities, in any manner, whether by operation of law or otherwise, such Registrable Securities shall be held subject to all of the terms of this Agreement, and by taking and holding such Registrable Securities such person shall be conclusively
deemed to have agreed to be bound by and to perform all of the terms and provisions of this Agreement, including the restrictions on resale set forth in this Agreement and, if applicable, the Purchase Agreement, and such person shall be entitled to
receive the benefits hereof. Merrill Lynch shall have no liability or obligation to the Company with respect to any failure by a Holder, other than Merrill Lynch, to comply with, or breach by any Holder, other than Merrill Lynch, of, any of the
obligations of such Holder under this Agreement. 
 5.7 Third Party Beneficiaries. Merrill Lynch (even if Merrill Lynch is not a
Holder of Registrable Securities) shall be a third party beneficiary to the agreements made hereunder between the Company, on the one hand, and the Holders, on the other hand, and shall have the right to enforce such agreements directly to the
extent it deems such enforcement necessary or advisable to protect its rights or the rights of Holders hereunder. Each Holder of Registrable Securities shall be a third party beneficiary to the agreements made hereunder between the Company, on the
one hand, and Merrill Lynch, on the other hand, and shall have the right to enforce such agreements directly to the extent it deems such enforcement necessary or advisable to protect its rights hereunder. 
 5.8 Specific Enforcement. Without limiting the remedies available to Merrill Lynch and the Holders, the Company acknowledges that any failure by
the Company to comply with its obligations under Section 2.1 hereof may result in material irreparable injury to Merrill Lynch or the Holders for which there is no adequate remedy at law, that it may not be possible to measure damages for such
injuries precisely and that, in the event of any such failure, Merrill Lynch or any Holder may seek such relief as may be required to specifically enforce the Company’s obligations under Section 2.1 hereof. 
 5.9 Counterparts. This Agreement may be executed in any number of counterparts and by the parties hereto in separate counterparts, each of which
when so executed shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. 
 5.10
Headings. The headings in this Agreement are for convenience of reference only and shall not limit or otherwise affect the meaning hereof. 
 5.11 GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE 
  

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 STATE OF NEW YORK (INCLUDING SECTIONS 5-1401 AND 5-1402 OF THE NEW YORK GENERAL OBLIGATIONS LAW BUT EXCLUDING ALL
OTHER CHOICE OF LAW AND CONFLICT OF LAW RULES). 
 5.12 Submission to Jurisdiction. Except as set forth below, no claim,
counterclaim or dispute of any kind or nature whatsoever arising out of or in any way relating to this Agreement (a “Claim”) may be commenced, prosecuted or continued in any court other than a federal or state court in the State of New
York, County of New York, which shall have jurisdiction over the adjudication of such matters, and the Company consents to the jurisdiction of such courts and personal service with respect thereto. The Company hereby consents to personal
jurisdiction, service and venue in any court in which any Claim arising out of or in any way relating to this Agreement is brought by any third party against Merrill Lynch or any indemnified party. Each of Merrill Lynch and the Company (on its
behalf and, to the extent permitted by applicable law, on behalf of its shareholders and affiliates) waives all right to trial by jury in any action, proceeding or counterclaim (whether based upon contract, tort or otherwise) in any way arising out
of or relating to this Agreement. The Company agrees that a final judgment in any such action, proceeding or counterclaim brought in any such court shall be conclusive and binding upon it and may be enforced in any other courts to the jurisdiction
of which it is or may be subject, by suit upon such judgment. The Company hereby appoints, without power of revocation, CT Corporation System at 111 Eighth Avenue, New York, New York 10011, as its agent to accept and acknowledge on its behalf
service of any and all process which may be served in any action, proceeding or counterclaim in any way relating to or arising out of this Agreement. 
 5.13 Judgment Currency. In respect of any judgment or order given or made for any amount due hereunder that is expressed and paid in a currency (the “judgment currency”) other than United States
dollars, the Company will indemnify Merrill Lynch against any loss incurred by Merrill Lynch as a result of any variation as between (a) the rate of exchange at which the United States dollar amount is converted into the judgment currency for
the purpose of such judgment or order and (b) the rate of exchange at which Merrill Lynch is able to purchase United States dollars with the amount of the judgment currency actually received by Merrill Lynch. The foregoing indemnity shall
constitute a separate and independent obligation of the Company and shall continue in full force and effect notwithstanding any such judgment or order as aforesaid. The term “rate of exchange” shall include any premiums and costs of
exchange payable in connection with the purchase of or conversion into United States dollars 
 5.14 Severability. In the event that
any one or more of the provisions contained herein, or the application thereof in any circumstance, is held invalid, illegal or unenforceable, the validity, legality and enforceability of any such provision in every other respect and of the
remaining provisions contained herein shall not be affected or impaired thereby. 
 5.15 Entire Agreement. This Agreement is intended
by the parties as a final expression of their agreement and intended to be a complete and exclusive statement of the agreement and understanding of the parties hereto in respect of the subject matter contained herein. There are no restrictions,
promises, warranties or undertakings, other than those set forth or referred to herein with respect to the registration rights granted by the Company with respect to the Registrable Securities. This Agreement supersedes all prior agreements and
understandings between the parties with respect to such subject matter. 
  

 21 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above.

  

			
	CHINA MEDICAL TECHNOLOGIES, INC.
		
	By:	 	 /s/ Takyung Tsang

	Name:	 	Takyung Tsang
	Title:	 	Chief Financial Officer

 Confirmed and accepted as 
     of the date first above written: 
  

			
	 MERRILL LYNCH, PIERCE, FENNER & SMITH
                         INCORPORATED

		
	By:	 	 /s/ Samuel Thong

	Name:	 	Samuel Thong
	Title:	 	Director

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