Document:

Fourth Amendment to Development and Supply Agreement

 Exhibit 10.6 
 Confidential treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as [***]. A complete
version of this exhibit has been filed separately with the Securities and Exchange Commission. 
 [***] 

FOURTH AMENDMENT 
 TO DEVELOPMENT AND SUPPLY AGREEMENT 
 Effective as of
date of the last signature below, Abbott Laboratories, an Illinois corporation having a principal place of business at 100 Abbott Park Road, Abbott Park, Illinois 60064-3500 (“Abbott”), and Seattle Genetics, Inc., a Delaware corporation
having a principal place of business at 21823 – 30th
Drive Southeast in Bothell, Washington 98021 (“Seattle Genetics”) (individually the “Party” or collectively the “Parties”) agree to the following terms and conditions (“Fourth Amendment”) as set forth below.

 WHEREAS, the Parties entered into a Development and Supply Agreement with an Effective Date of February 23, 2004
for the manufacture of a chimeric anti-CD30 AC10 monoclonal antibody known as cAC10 Bulk Drug Substance (the “Original Agreement”), which also constitutes the antibody component of SGN-35 and the Parties subsequently entered into three
amendments to the Original Agreement (the “First Amendment”, “Second Amendment” and “Third Amendment”, collectively with the Original Agreement, hereinafter referred to as the “Agreement”); and 

WHEREAS, the Parties have agreed to conduct additional development and manufacturing work pursuant to the terms and conditions of
the Agreement; and 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements contained here and for
other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties agree as follows: 
 1. Incorporation of the Agreement. All capitalized terms which are used but not otherwise defined herein shall have the same meanings as set forth in the Agreement, and the Agreement, to the extent
not inconsistent with this Fourth Amendment, is incorporated herein by this reference as though the same was set forth in its entirety. To the extent any terms and provisions of the Agreement are inconsistent with the amendments set forth in
Paragraphs 2 and 3 below, such terms and provisions shall be deemed superseded hereby. Except as specifically set forth herein, the Agreement shall remain in full force and effect and its provisions shall be binding on the parties. 

2. Process Development Work. The Parties agree that Abbott shall perform the activities set forth in Stage 13 of Attachment 1
hereto pursuant to the terms and conditions of the Agreement. 
 3. Payment Schedule. As compensation for the activities
to be performed by Abbott pursuant to Attachment 1 hereto, Seattle Genetics shall pay to Abbott the price established for each project stage on the dates set forth in Attachment 2. Billings associated with this Fourth Amendment may be combined on
the same invoice with other, regular Payment Schedule charges. 
 4. Project References. All references to the Project
set forth in the Agreement, with the exception of the Payment Schedule and Facility Reservation Fee for the Project shall also be deemed to apply to the activities performed by Abbott, pursuant to this Fourth Amendment. 

5. Effectuation. The amendment to the Agreement contemplated by this Fourth Amendment shall be deemed effective as of the last
date written below upon the full execution of this Fourth Amendment and without any further action required by the parties hereto. There are no conditions precedent or subsequent to the effectiveness of this Fourth Amendment. All terms and

 
conditions set forth in Agreement that are not amended hereby shall remain in full force and effect. Any term of this Fourth Amendment may be amended with the written consent of both parties.
From the date hereof, any reference to the Agreement shall be deemed to refer to the Agreement as amended by this Fourth Amendment. 
 6. Counterparts. This Fourth Amendment may be executed in two or more counterparts, each of which shall be deemed to be an original, but all of which together shall constitute one and the same
instrument. One or more counterparts of this Fourth Amendment may be delivered by facsimile, with the intention that delivery by such means shall have the same effect as delivery of an original counterpart thereof. 

7. Entire Agreement. This Fourth Amendment and exhibits hereto are the product of both of the parties hereto, and together with
the Agreement and exhibits thereto constitute the entire agreement between such parties pertaining to the subject matter hereof, and merge all prior negotiations and drafts of the parties with regard to the transactions contemplated herein.

 IN WITNESS WHEREOF, the parties have executed this Fourth Amendment as of the dates set forth below. 

 

									
	ABBOTT LABORATORIES	 	 	 	SEATTLE GENETICS, INC.
					
	By:	 	 /s/ Steve Lichter
	 		 	By:	 	 /s/ Clay B. Siegall

					
	Name:	 	 Steve Lichter
	 		 	Name:	 	 Clay B. Siegall

					
	Title:	 	 Vice President, Pharmaceutical Manufacturing
	 		 	Title:	 	 President & CEO

					
	Date:	 	 4/18/2010
	 		 	Date:	 	 4/6/2010

  

					
	11/3/2011	  	2	  	CONFIDENTIAL

 ATTACHMENT 2 
 [***] 
 [***] Certain information on this page has been omitted and filed separately with the
Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

 Updated Payment Schedule 

[***] 
 [***] Certain information
on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  

					
	11/3/2011	  	4	  	CONFIDENTIALFifth Amendment to Development and Supply Agreement

 Exhibit 10.7 
 Confidential treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as [***]. A complete
version of this exhibit has been filed separately with the Securities and Exchange Commission. 
 [***] 

FIFTH AMENDMENT 
 TO DEVELOPMENT AND SUPPLY AGREEMENT 
 Effective as of
date of the last signature below, Abbott Laboratories, an Illinois corporation having a principal place of business at 100 Abbott Park Road, Abbott Park, Illinois 60064-3500 (“Abbott”), and Seattle Genetics, Inc., a Delaware corporation
having a principal place of business at 21823 – 30th
Drive Southeast in Bothell, Washington 98021 (“Seattle Genetics”) (individually the “Party” or collectively the “Parties”) agree to the following terms and conditions (“Fifth Amendment”) as set forth below.

 WHEREAS, the Parties entered into a Development and Supply Agreement with an Effective Date of February 23, 2004
for the manufacture of a chimeric anti-CD30 AC10 monoclonal antibody known as cAC10 Bulk Drug Substance (the “Original Agreement”), which also constitutes the antibody component of SGN-35 and the Parties subsequently entered into four
amendments to the Original Agreement (the “First Amendment”, “Second Amendment”, “Third Amendment”, and “Fourth Amendment”, respectively. Collectively the Original Agreement, the First Amendment, the Second
Amendment, the Third Amendment and the Fourth Amendment are hereinafter referred to as the “Agreement”); and 

WHEREAS, the Parties desire to further amend the Agreement as herein provided as of the date hereof. 

NOW, THEREFORE, in consideration of the mutual covenants and agreements contained here and for other good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties agree as follows: 
 1. Incorporation
of the Agreement. All capitalized terms which are used but not otherwise defined herein shall have the same meanings as set forth in the Agreement, and the Agreement, to the extent not inconsistent with this Fifth Amendment, is incorporated
herein by this reference as though the same was set forth in its entirety. To the extent any terms and provisions of the Agreement are inconsistent with the amendments set forth in Paragraph 2 below, such terms and provisions shall be deemed
superseded hereby. Except as specifically set forth herein, the Agreement shall remain in full force and effect and its provisions shall be binding on the parties. 
 2. Amendment of the Agreement. The Agreement is hereby amended as follows: 

a. Section 1.55 is hereby added as follows: 
 “1.55 “[***]” means [***] of Bulk Drug Substance per [***].” 

b. Section 9.9 is hereby added as follows: 
 “9.9 [***]. [***]. [***].” 
 c. Section 12.8 is hereby
amended by adding the following to the end of the first sentence of Section 12.8: 
 “provided, however, if the amount
of commercial Bulk Drug Substance purchased by Seattle Genetics in the [***]. Seattle Genetics shall have [***] (a) [***] and (b) [***].” 
 d. Section 9.10 shall be added as follows: 
 “9.10 [***]. [***].”

 3. Bulk Drug Substance Pricing. Exhibit D shall hereby be deleted in its entirety and
replaced by the new Exhibit D attached to this Amendment. 
 4. Effectuation. The amendment to the Agreement contemplated
by this Fifth Amendment shall be deemed effective as of the last date written below upon the full execution of this Fifth Amendment and without any further action required by the parties hereto. There are no conditions precedent or subsequent to the
effectiveness of this Fifth Amendment. All terms and conditions set forth in Agreement that are not amended hereby shall remain in full force and effect. Any term of this Fifth Amendment may be amended with the written consent of both parties. From
the date hereof, any reference to the Agreement shall be deemed to refer to the Agreement as amended by this Fifth Amendment. 

5. Counterparts. This Fifth Amendment may be executed in two or more counterparts, each of which shall be deemed to be an
original, but all of which together shall constitute one and the same instrument. One or more counterparts of this Fifth Amendment may be delivered by facsimile, with the intention that delivery by such means shall have the same effect as delivery
of an original counterpart thereof. 
 6. Entire Agreement. This Fifth Amendment and exhibits hereto are the product of
both of the parties hereto, and together with the Agreement and exhibits thereto constitute the entire agreement between such parties pertaining to the subject matter hereof, and merge all prior negotiations and drafts of the parties with regard to
the transactions contemplated herein. 
 IN WITNESS WHEREOF, the parties have executed this Fifth Amendment as of the
dates set forth below. 
  

									
	ABBOTT LABORATORIES	 	 	 	SEATTLE GENETICS, INC.
					
	By:	 	 /s/ Keith A. Kentala
	 		 	By:	 	 /s/ Clay B. Siegall

					
	Name:	 	 Keith A. Kentala
	 		 	Name:	 	 Clay B. Siegall

					
	Title:	 	 GM, Commercial Operations
	 		 	Title:	 	 President & CEO

					
	Date:	 	 8/24/2010
	 		 	Date:	 	 8/20/2010

 [***] 
 EXHIBIT D 
 Bulk Drug Substance Pricing 

[***] 
 [***] Certain
information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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