Document:

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Exhibit 4.2

CERTIFICATE OF AMENDMENT

OF

CERTIFICATE OF INCORPORATION

New GulfMark International, Inc., a corporation organized and existing under and by virtue of the
General Corporation Law of the State of Delaware,

DOES HEREBY CERTIFY:

FIRST: That the Board of Directors of said corporation, by unanimous written consent of its members
filed with the minutes of the Board, adopted a resolution proposing and declaring advisable the
following amendment to the Certificate of Incorporation of said corporation:

     RESOLVED, that the Board of Directors hereby recommends to the Corporation’s sole shareholder
that article First of the Corporation’s Certificate of Incorporation be amended to read as follows:

          “FIRST. The name of the corporation (the “Corporation”) is GulfMark Offshore, Inc.”

     RESOLVED, that, upon approval by the Corporation’s sole shareholder, the Corporation’s
Certificate of Incorporation be amended to change the corporate name from New GulfMark
International, Inc. to GulfMark Offshore, Inc.

SECOND: That in lieu of a meeting and vote of stockholders, the sole stockholder has given its
written consent to the said amendment in accordance with the provisions of Section 228 of the
General Corporation Law of the State of Delaware.

THIRD: That the aforesaid amendment was duly adopted in accordance with the applicable provisions
of Sections 242 and 228 of the General Corporation Law of the State of Delaware.

IN WITNESS WHEREOF, said New GulfMark International, Inc. has caused this certificate to be signed
by Frank R. Pierce, its Executive Vice President, this 6th day of March, 1997.

	 	 	 	 	 
	 	NEW GULFMARK INTERNATIONAL, INC.

 	 
	 	By:  	/s/ Frank R. Pierce
 	 
	 	 	Frank R. Pierce, Executive Vice President 	 
	 	 	 	 

 

 

	 	 	 	 	 

STATE OF TEXAS

COUNTY OF HARRIS

     This instrument was acknowledged before me on the 6th day of March, 1997 by Frank R. Pierce as
Executive Vice President of New GulfMark International, Inc. Such person acknowledged to me that
this Certificate of Amendment of Certificate of Incorporation is the deed and act of New GulfMark
International, Inc. and that all facts stated herein are true.

     GIVEN UNDER MY HAND AND SEAL OF OFFICE this 6th day of March, 1997.

	 	 	 	 	 
	 	 	 
	 	                            /s/ Janis Buchanan
 	 
	 	Notary Public In and For 	 
	 	The State of Texasexv4w3

Exhibit 4.3

CERTIFICATE OF AMENDMENT

OF

CERTIFICATE OF INCORPORATION

GulfMark Offshore, Inc., a corporation organized and existing under and by virtue of the General
Corporation Law of the State of Delaware (the “Company”),

DOES HEREBY CERTIFY:

FIRST: That at the February 27, 2002 meeting of the Board of Directors of the Company, resolutions
were duly adopted setting forth a proposed amendment to the Certificate of Incorporation of the
Company, declaring said amendment to be advisable and recommending that the amendment be presented
to the shareholders of the Company for consideration thereof at the 2002 annual meeting of
shareholders. The proposed amendment is as follows:

     FOURTH. The total number of shares of stock which the Corporation shall have authority to
issue is 32,000,000, consisting of 2,000,000 shares of Preferred Stock, without par value
(hereinafter called “Preferred Stock”), and 30,000,000 shares of Common Stock, of the par value of
$0.01 per share (hereinafter called “Common Stock”).

SECOND: That thereafter, an annual meeting of the shareholders of the Company was duly called and
held upon notice in accordance with Section 222 of the General Corporation Law of the State of
Delaware, at which meeting the necessary number of shares as required by statute were voted in
favor of the amendment.

THIRD: That the aforesaid amendment was duly adopted in accordance with the applicable provisions
of Sections 242 of the General Corporation Law of the State of Delaware.

IN WITNESS WHEREOF, the Company has caused this certificate to be signed by Bruce A. Streeter, its
President, this 24th day of May, 2002.

	 	 	 	 	 
	 	 	GULFMARK OFFSHORE, INC.

 	 
	 	By:  	/s/ Bruce A. Streeter
 	 
	 	 	Bruce A. Streeter, President 	 
	 	 	 	 

 

 

	 	 	 	 	 

STATE OF NEW YORK

COUNTY OF NEW YORK

     This instrument was acknowledged before me on the 24th day of May, 2002 by Bruce A. Streeter
as Executive Vice President of GulfMark Offshore, Inc. Such person acknowledged to me that this
Certificate of Amendment of Certificate of Incorporation is the deed and act of GulfMark Offshore,
Inc. and that all facts stated herein are true.

     GIVEN UNDER MY HAND AND SEAL OF OFFICE this 24th day of May, 2002.

	 	 	 	 	 
	 	 	 
	 	                            /s/ Maureen G. Scollo
 	 
	 	Notary Public In and For 	 
	 	The State of New Yorkexv10w1

Exhibit 10.1

SERIES 6-A PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT

     THIS SERIES 6-A PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT (the “Agreement”) is
made as of the ___day of                     , 2008 (the “Effective Date”) by and among Tri-Isthmus
Group, Inc., a Delaware corporation (the “Company”), and
                                                             (the “Purchaser”).

     The parties hereby agree as follows:

1. Authorization and Sale of Shares and Warrants.

     1.1 Authorization. The Company has duly authorized the sale and issuance of up to
5,000 shares (the “Shares”) of its Series 6-A Convertible Preferred Stock, par value $0.01
per share (the “Series 6-A Preferred”), and warrants to purchase up to 3,000,000 shares of
the Company’s common stock, par value $0.01 per share (the “Common Stock”), at an exercise
price of $0.50 per share substantially in the form attached hereto as Exhibit A (the
“Warrants”). For purposes of this Agreement, a “Unit” shall consist of one share
of Series 6-A Preferred and one Warrant to purchase 600 shares of Common Stock.

     1.2 Purchase and Sale. Upon the terms and subject to the conditions herein, and in
reliance on the representations, warranties and covenants set forth herein, upon Closing Purchaser
shall purchase from the Company, and the Company shall issue and sell to Purchaser,                     
Units, for a purchase price of $1,000.00 per Unit (the “Purchase Price”).

     1.3 Defined Terms Used in this Agreement. The following terms used in this Agreement
shall be construed to have the meanings set forth below.

          “Affiliate” means with respect to any person or entity (a “Person”), any
Person which, directly or indirectly, controls, is controlled by, or is under common control with
such Person, including, without limitation, any partner, officer, director, or member of such
Person.

          “Balance Sheet” means the Company’s balance sheet as of September 30, 2007 included in
the Company’s Annual Report on Form 10-K for the transition period ended September 30, 2007.

          “Code” means the Internal Revenue Code of 1986, as amended.

          “Exchange Act” means the Securities Exchange Act of 1934, as amended.

          “Material Adverse Effect” means a material adverse effect on the assets or liabilities
of the Company.

          “SEC” means the United States Securities and Exchange Commission.

          “Securities Act” means the Securities Act of 1933, as amended.

 

 

2. Closing; Deliveries.

     2.1 Closing. The purchase and sale of the Units shall occur upon the Company’s
execution of this Agreement and be effective as of the Effective Date (the “Closing”).

     2.2 Deliveries; Certificate of Designation.

          (a) Shares and Warrants; Purchase Price. At or after the Closing, the Company shall
deliver to Purchaser certificates representing the Shares and the Warrants being purchased by
Purchaser against payment of the Purchase Price to the Company.

          (b) Certificate of Designation. The Company has previously filed the Certificate of
Designation of the Company, in the form attached hereto as Exhibit B (the “Certificate
of Designation”), which establishes the rights and preferences of the Series 6-A Preferred.

3. Representations and Warranties of the Company. The Company hereby represents and
warrants to Purchaser that the following representations are true and correct as of the date
hereof. For purposes of these representations and warranties, the phrase “to the Company’s
knowledge” shall mean the actual knowledge of David Hirschhorn or Dennis Smith.

     3.1 Organization, Good Standing, Corporate Power and Qualification. The Company is a
corporation duly organized, validly existing and in good standing under the laws of the State of
Delaware and has all requisite corporate power and authority to carry on its business as presently
conducted and as proposed to be conducted. The Company is duly qualified to transact business and
is in good standing in each jurisdiction in which the failure to so qualify would have a Material
Adverse Effect.

     3.2 Capitalization. The authorized capital stock of the Company consists of (i)
100,000,000 shares of Common Stock, 8,177,629 shares of which are issued and outstanding, and (ii)
5,000,000 shares of preferred stock, of which (a) 67,600 shares of Series 1-A Preferred Stock, par
value $0.01 per share, (b) 3,900 shares of Series 2-A Preferred Stock, par value $0.01 per share,
(c) 7,462 shares of Series 5-A Preferred Stock, par value $0.01 per share, and (d) 3,585 shares of
Series 6-A Preferred are issued and outstanding. Except as disclosed on Schedule 3.2 and
as contemplated hereby, there are no outstanding subscriptions, options, warrants, commitments,
agreements or arrangements for or relating to the issuance, or sale of, or outstanding securities
convertible into or exchangeable for, any shares of capital stock of any class or other equity
interests of the Company. As of the Closing, and after giving effect to the transactions
contemplated hereby, all of the outstanding shares of capital stock of the Company will have been
duly and validly authorized and issued and will be fully paid and non-assessable and will have been
offered, issued, sold and delivered in compliance with applicable federal and state securities laws
and not subject to any preemptive rights. When issued in accordance with the terms of the Series
6-A Preferred and the Warrants, the shares of Common Stock issuable upon exercise of Series 6-A
Preferred and the Warrants will be validly issued, fully paid and non-assessable. The terms
relating to the Warrants are as set forth in Exhibit A attached hereto. The relative
rights, preferences and other terms relating to the Series 6-A Preferred are as set

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

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forth in Exhibit B attached hereto. There are no preemptive rights, rights of first
refusal, put or call rights or obligations or any other purchase or redemption obligations or
anti-dilution rights with respect to the Company’s capital stock or any interests therein, other
than as disclosed on Schedule 3.2 or rights set forth herein or in the Company’s
Certificate of Incorporation or the Certificates of Designation establishing such capital stock.
Other than as set forth herein, there are no rights to have the Company’s capital stock registered
for sale to the public in connection with the laws of any jurisdiction, and there are no agreements
relating to the voting of the Company’s voting securities or restrictions on the transfer of the
Company’s capital stock.

     3.3 Authorization; No Conflict. The execution, delivery and performance by the
Company of this Agreement, and the consummation by the Company of the transactions contemplated
hereby, have been duly authorized by all necessary corporate action. This Agreement has been duly
executed and delivered by the Company and constitutes the valid and binding obligation of the
Company enforceable in accordance with its terms. The execution of and performance of the
transactions contemplated by this Agreement and the compliance with its provisions by the Company
will not (a) conflict with or violate any provision of the Certificate of Incorporation or Bylaws
of the Company, (b) conflict with, result in a breach of, constitute (with or without due notice or
lapse of time or both) a default under, result in the acceleration of, create in any party the
right to accelerate, terminate, modify or cancel, or require any notice, consent or waiver under,
any material contract, lease, sublease, license, sublicense, franchise, permit, indenture,
agreement or mortgage for borrowed money, instrument of indebtedness, Security Interest (as defined
below) or other arrangement to which the Company is a party or by which the Company is bound or to
which its assets are subject, (c) result in the imposition of any Security Interest upon any assets
of the Company or (d) violate any order, writ, injunction, decree, statute, rule or regulation
applicable to the Company or any of its properties or assets. For purposes of this Agreement,
“Security Interest” means any mortgage, pledge, security interest, encumbrance, charge, or
other lien (whether arising by contract or by operation of law).

     3.4 Valid Issuance of Shares. The Shares, when issued, sold and delivered in
accordance with the terms and for the consideration set forth in this Agreement, will be validly
issued, fully paid and non-assessable and free of restrictions on transfer other than restrictions
on transfer under applicable state and federal securities laws and liens or encumbrances created by
or imposed by Purchaser. Assuming the accuracy of the representations of Purchaser in Section
4 of this Agreement and subject to the filings described in Section 3.5 below, the
Shares will be issued in compliance with all applicable federal and state securities laws. The
Common Stock issuable upon conversion of the Shares and exercise of the Warrants has been duly
reserved for issuance, and upon issuance, will be validly issued, fully paid and non-assessable and
free of restrictions on transfer other than restrictions on transfer under applicable federal and
state securities laws and liens or encumbrances created by or imposed by Purchaser. Based in part
upon the representations of the Purchaser in Section 4 of this Agreement, and subject to
Section 3.5 below, the Common Stock issuable upon conversion of the Shares and exercise of
the Warrants will be issued in compliance with all applicable federal and state securities laws.

     3.5 Governmental Consents and Filings. Assuming the accuracy of the representations
made by the Purchaser in Section 4 of this Agreement, no consent, approval, order or
authorization of, or registration, qualification, designation, declaration or filing with,

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

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any federal, state or local governmental authority is required on the part of the Company in
connection with the consummation of the transactions contemplated by this Agreement, except such
filings as shall have been made prior to and shall be effective on and as of the Closing and such
filings required to be made after the Closing under applicable federal and state securities laws.

     3.6 Subsidiaries. The Company’s subsidiaries are as set forth in the Company’s Annual
Report on Form 10-K for the transition period ended September 30, 2007.

     3.7 Compliance with Laws. The Company has complied in all material respects with all
laws, regulations and orders applicable to its present and currently proposed business and has all
material permits and licenses required thereby, except where the failure to have such permits or
licenses would not have a Material Adverse Effect.

     3.8 Absence of Litigation. Except as disclosed in the Company’s periodic reports
filed with the Securities and Exchange Commission (the “SEC Filings”), there is no action,
suit or proceeding pending or, to the Company’s knowledge, threatened, against the Company which
questions the validity of this Agreement or the right of the Company to enter into it, or which
might result, either individually or in the aggregate, in a Material Adverse Effect.

     3.9 Absence of Liabilities. The Company does not have any material liabilities or
obligations, whether accrued, absolute, contingent or otherwise, of the type required to be
disclosed on a balance sheet other than (i) such matters as are specifically and expressly set
forth on the Balance Sheet or (ii) those which have been incurred by the Company in the ordinary
course of business during the period from the date of the Balance Sheet to the date hereof.

     3.10 Material Contracts and Obligations. Except as disclosed in the Company’s SEC
Filings or as disclosed on Schedule 3.10, the Company is not a party to, nor is it bound by
any of the following types of agreements: (a) any agreement which requires future expenditures by
the Company in excess of $25,000 or which might result in payments to the Company in excess of
$25,000, (b) any agreement with any current officer or director of the Company, or any “affiliate”
or “associate” of such persons (as such terms are defined in the rules and regulations promulgated
under the Securities Act), including without limitation any agreement or other arrangement
providing for the furnishing of services by, rental of real or personal property from, or otherwise
requiring payments to, any such Person, (c) any agreement under which the Company is restricted
from carrying on any business or other services anywhere in the world, (d) any agreement for the
disposition of a material portion of the Company’s assets or (e) any agreement for the acquisition
of the business or shares of another party.

     3.11 Changes. Except as disclosed in the Company’s SEC Filings, and in Schedule
3.11, since September 30, 2007, there has not been:

          (a) any material change in the assets or liabilities of the Company from that reflected on the
Balance Sheet, except changes in the ordinary course of business that have not caused, in the
aggregate, a Material Adverse Effect;

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

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          (b) any damage, destruction or loss, whether or not covered by insurance, that would have a
Material Adverse Effect;

          (c) any waiver or compromise by the Company of a valuable right or of a material debt owed to
it;

          (d) any satisfaction or discharge of any lien, claim, or encumbrance or payment of any
obligation by the Company, except in the ordinary course of business and the satisfaction or
discharge of which would not have a Material Adverse Effect;

          (e) any material change to a material contract or agreement by which the Company or any of its
assets is bound or subject;

          (f) any material change in any compensation arrangement or agreement with any employee,
officer, director or stockholder;

          (g) any mortgage, pledge, transfer of a security interest in, or lien, created by the Company,
with respect to any of its material properties or assets, except liens for taxes not yet due or
payable and liens that arise in the ordinary course of business and do not materially impair the
Company’s ownership or use of such property or assets;

          (h) any loans or guarantees made by the Company to or for the benefit of its employees,
officers or directors, or any members of their immediate families, other than travel advances and
other advances made in the ordinary course of its business;

          (i) any declaration, setting aside or payment or other distribution in respect of any of the
Company’s capital stock, or any direct or indirect redemption, purchase, or other acquisition of
any of such stock by the Company;

          (j) to the Company’s knowledge, any other event or condition of any character, other than
events affecting the economy or the Company’s industry generally, that could reasonably be expected
to result in a Material Adverse Effect; or

          (k) any agreement or commitment by the Company to do any of the foregoing.

     3.12 Employees. The Company’s only current employees are David Hirschhorn, Dennis
Smith, and Karla Soto.

     3.13 Tax Returns and Payments. There are no federal, state, county, local or foreign
taxes due and payable by the Company which have not been timely paid. There are no accrued and
unpaid federal, state, country, local or foreign taxes of the Company which are due, whether or not
assessed or disputed. There have been no examinations or audits of any tax returns or reports by
any applicable federal, state, local or foreign governmental agency. The Company has duly filed
all federal, state, county, local and foreign tax returns required to have been filed by it and
there are in effect no waivers of applicable statutes of limitations with respect to taxes for any
year.

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

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     3.14 No Stop Order. No stop order suspending or prohibiting the transactions
contemplated by this Agreement has been issued by the SEC or the regulatory authorities of any
state and, to the Company’s knowledge, no proceeding for that purpose has been initiated or is
threatened or contemplated by the SEC or the regulatory authorities of any state.

     3.15 Quotation of Common Stock. The Company’s Common Stock continues to be quoted on
the OTC Bulletin Board under the ticker symbol, “TISG.PK”.

     3.16 Directors and Officer’s Liability Insurance. The Company has made all payments
under its existing policy of directors and officers’ liability insurance on a timely basis.

4. Representations and Warranties of the Purchaser. Purchaser hereby represents and
warrants to the Company, that:

     4.1 Authorization. The Purchaser has full power and authority to enter into this
Agreement. This Agreement, when executed and delivered by the Purchaser, will constitute the valid
and legally binding obligation of the Purchaser, enforceable in accordance with its terms.

     4.2 Purchase for Own Account; Accredited Investor. This Agreement is made with the
Purchaser in reliance upon the Purchaser’s representation to the Company, which by the Purchaser’s
execution of this Agreement, the Purchaser hereby confirms, that the Shares to be acquired by the
Purchaser will be acquired for investment for the Purchaser’s own account, not as a nominee or
agent, and not with a view to the resale or distribution of any part thereof, and that the
Purchaser has no present intention of selling, granting any participation in, or otherwise
distributing the same. By executing this Agreement, the Purchaser further represents that the
Purchaser does not presently have any contract, undertaking, agreement or arrangement with any
Person to sell, transfer or grant participations to such Person or to any third Person, with
respect to any of the Shares. The Purchaser has not been formed for the specific purpose of
acquiring the Shares. The Purchaser is an “accredited investor” as that term is defined in Rule
501(a) of Regulation D promulgated under the Securities Act.

     4.3 Experience. The Purchaser has carefully reviewed the representations concerning
the Company contained in this Agreement and has made detailed inquiry concerning the Company, its
business and its personnel. The officers of the Company have made available to the Purchaser any
and all information which the Purchaser has requested and have answered to the Purchaser’s
satisfaction all inquiries made by the Purchaser; and the Purchaser has sufficient knowledge and
experience in finance and business that it is capable of evaluating the risks and merits of its
investment in the Company and the Purchaser is able financially to bear the risks thereof.

     4.4 Restricted Securities. The Purchaser understands that the issuance of the Shares
and the Warrants and the Common Stock issuable upon conversion of the Shares and exercise of the
Warrants have not been registered under the Securities Act, by reason of a specific exemption from
the registration provisions of the Securities Act which depends upon, among other things, the bona
fide nature of the investment intent and the accuracy of the Purchaser’s representations as
expressed herein. The Purchaser understands that the Shares, the Warrants and the Common

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

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Stock issuable upon conversion of the Shares and exercise of the Warrants are “restricted
securities” under applicable U.S. federal and state securities laws and that, pursuant to these
laws, the Purchaser must hold the Shares, the Warrants and such Common Stock indefinitely unless
the resales of same are registered with the SEC and qualified by state authorities, or an exemption
from such registration and qualification requirements is available. The Purchaser acknowledges
that, except as otherwise provided herein, the Company has no obligation to register or qualify the
resale of the Shares, the Warrants or the Common Stock issuable upon conversion of the Shares or
exercise of the Warrants for resale. The Purchaser further acknowledges that if an exemption from
registration or qualification is available, it may be conditioned on various requirements
including, but not limited to, the time and manner of sale, the holding period for the Shares, the
Warrants and the Common Stock issuable upon conversion of the Shares and exercise of the Warrants,
and on requirements relating to the Company which are outside of the Purchaser’s control, and which
the Company is under no obligation and may not be able to satisfy.

     4.5 Legends. The Purchaser understands that the Shares, the Warrants and any
securities issued in respect of or exchange for the Shares or exercise of the Warrants, may bear
one or all of the following legends:

          (a) “THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH,
THE SALE OR DISTRIBUTION THEREOF. NO SUCH TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE
REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.”

          (b) Any legend required by the securities laws of any state to the extent such laws are
applicable to the Shares and the Warrants represented by the certificate so legended.

5. Directors’ and Officers’ Insurance and Indemnification. From and after the Closing and
for a period of six years, the Company will provide standard and customary directors’ and officers’
liability insurance coverage commercially consistent with the then-applicable size of the Company
and its operations to current and former officers and directors of the Company (all such directors
and officers are referred to herein as the “Covered Persons”), including run-off for past acts.
From and after the Closing, the Company will fulfill and honor in all respects the obligations of
the Company pursuant to any indemnification obligations of the Company with respect to each of the
Covered Persons, and any indemnification provisions under the Company’s certificate of
incorporation and bylaws will contain provisions with respect to exculpation and indemnification
that are at least as favorable to the Covered Persons as those contained in the certificate of
incorporation and bylaws of the Company as in effect on the date hereof, which provisions will not
be amended, repealed or otherwise modified for a period of six years from the Closing in any manner
that would adversely affect the rights of the Covered Persons, unless such modification is required
by law. This covenant shall be enforceable by the Covered Persons as third party beneficiaries,
and shall be binding on all successors and assigns of the Company.

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6. Registration Rights.

     6.1 Registration Obligations. Upon demand by holders of Series 6-A Preferred owning
at least Fifty Percent (50%) of the outstanding Shares, the Company shall include the shares of
Common Stock issuable upon conversion of the Series 6-A Preferred and exercise of the Warrants (the
“Registrable Securities”) in a registration statement prepared by the Company and filed
with the SEC within thirty (30) days of such demand (the “Registration Statement”);
provided, that no demand shall be made by Purchaser sooner than the six month anniversary
of the Closing and the Purchaser shall be entitled to only one demand to register the resale of the
Registrable Securities pursuant to this Section 6.1. The Registration Statement will be on
Form SB-2 or other appropriate form (as the Company shall determine in its sole discretion) and
will permit the Registrable Securities to be offered on a continuous basis. The Company shall use
its commercially reasonable efforts to cause the Registration Statement to be declared effective
under the Securities Act by the SEC as promptly as possible after the filing thereof. The Company
shall use its commercially reasonable efforts to keep the Registration Statement continuously
effective under the Securities Act until the date which is the earliest of (a) the date on which
all Registrable Securities have been sold, (b) the date on which all Registrable Securities may be
sold immediately without registration under the Securities Act and without volume restrictions
pursuant to Rule 144(k) of the Securities Act or (c) two years from the date the Registration
Statement is declared effective by the SEC.

     6.2 Suspension of Registration Obligations. The Company’s obligations under this
Section 8 shall be suspended if (a) the fulfillment of such obligations would require the
Company to make a disclosure that would be detrimental to the Company and the Company’s Board of
Directors determines that it is in the best interests of the Company to defer such obligations or
(b) the fulfillment of such obligations would require the Company to prepare financial statements
not required to be prepared by the Company to comply with its obligations under the Exchange Act at
the time the Registration Statement is proposed to be filed (the period during which either of the
preceding conditions is in effect is referred to as a “Permitted Black-Out Period”). A
Permitted Black-Out Period will end, as applicable, upon the making of the relevant disclosure by
the Company (or, if earlier, when such disclosure would no longer be necessary or detrimental) or
as soon as it would no longer be necessary to prepare such financial statements to comply with the
Securities Act.

     6.3 Expenses; Indemnification. The Company shall pay all costs and expenses incurred
by the Company in connection with the preparation and filing of the Registration Statement, other
than selling commissions and fees which shall be the sole responsibility of the Purchaser. The
Company and Purchaser shall provide each other with customary indemnification rights in connection
with the Registration Statement prepared and filed with the SEC pursuant to this Section 6.

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7. Indemnification.

     7.1 Indemnification by the Company. The Company shall indemnify and hold harmless
Purchaser and its officers, directors, agents, Affiliates, principal shareholders, successors and
assigns from and against any and all claims, demands, liabilities, obligations, damages, costs, and
expenses (including reasonable attorneys’ fees) (collectively, “Losses”) arising out of any
breach of the Company’s representations, warranties, covenants or agreements set forth herein;
provided, however, that (a) the Company shall not indemnify Purchaser for any
Losses resulting from Purchaser’s negligence or intentional misconduct or any breach of Purchaser’s
representations, warranties, covenants or agreements hereunder; and (b) the Company’s total
liability under this Section 7.1 shall not exceed the aggregate consideration paid to the
Company by Purchaser for the Units issued and sold pursuant to this Agreement.

     7.2 Indemnification by the Purchaser. Purchaser will indemnify and hold harmless the
Company and its officers, directors, agents, Affiliates, principal shareholders, successors and
assigns from and against any and all Losses arising out of any breach of the Purchaser’s
representations, warranties, covenants or agreements set forth herein; provided,
however, that the Purchaser shall not indemnify the Company for any Losses resulting from
the Company’s negligence or intentional misconduct or any breach of the Company’s representations,
warranties, covenants or agreements hereunder.

8. Miscellaneous.

     8.1 Survival of Representations and Warranties. The representations and warranties of
the Company and the Purchaser contained in or made pursuant to this Agreement shall survive the
execution and delivery of this Agreement and the Closing for a period of one year following the
Closing.

     8.2 Successors and Assigns; No Third Party Beneficiaries. The terms and conditions of
this Agreement shall inure to the benefit of and be binding upon the respective successors and
assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon
any party other than the parties hereto or their respective successors and assigns any rights,
remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly
provided in this Agreement.

     8.3 Governing Law. This Agreement shall be governed by and construed in accordance
with the internal substantive laws of the State of Delaware, without regard to its principles of
conflicts of laws.

     8.4 Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute one and the same
instrument. This Agreement may also be executed and delivered by facsimile signature and in two or
more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

9

 

     8.5 Notices. All notices and other communications given or made pursuant to this
Agreement shall be in writing and shall be deemed effectively given: (a) upon personal delivery to
the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during
normal business hours of the recipient, and if not so confirmed, then on the next business day, (c)
five (5) days after having been sent by registered or certified mail, return receipt requested,
postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier,
specifying next day delivery, with written verification of receipt. All communications shall be
sent to the respective parties at their address as set forth on the signature page, or to such
e-mail address, facsimile number or address as subsequently modified by written notice given in
accordance with this Section 8.5. If notice is given to the Company, a copy shall also be
sent to K&L Gates LLP, 1717 Main Street, Suite 2800, Dallas, Texas 75201, Attention: I. Bobby
Majumder.

     8.6 No Finder’s Fees. Each party represents that it neither is nor will be obligated
for any finder’s fee or commission in connection with the transactions contemplated by this
Agreement. Purchaser agrees to indemnify and to hold harmless the Company from any liability for
any commission or compensation in the nature of a finder’s fee arising out of the transactions
contemplated hereby (and the costs and expenses of defending against such liability or asserted
liability) for which Purchaser or any of its officers, employees, or representatives is
responsible. The Company agrees to indemnify and hold harmless Purchaser from any liability for
any commission or compensation in the nature of a finder’s or broker’s fee arising out of the
transactions contemplated hereby (and the costs and expenses of defending against such liability or
asserted liability) for which the Company or any of its officers, employees or representatives
is responsible.

     8.7 Fees and Expenses. All fees and expenses incurred in connection with the
transactions contemplated by this Agreement shall be paid by the party incurring such fees or
expenses.

     8.8 Amendments and Waivers. Except as otherwise expressly set forth in this
Agreement, any term of this Agreement may be amended, terminated or waived only with the written
consent of the Company and the holders of at least a majority of the then-outstanding Shares. Any
amendment or waiver effected in accordance with this Section 8.8 shall be binding upon the
Purchaser and each transferee of the Shares (or the Common Stock issuable upon conversion thereof),
each future holder of all such securities, and the Company.

     8.9 Severability. The invalidity or unenforceability of any provision hereof shall in
no way affect the validity or enforceability of any other provision.

     8.10 Delays or Omissions. No delay or omission to exercise any right, power or remedy
accruing to any party under this Agreement, upon any breach or default of any other party under
this Agreement, shall impair any such right, power or remedy of such non-breaching or
non-defaulting party nor shall it be construed to be a waiver of any such breach or default, or an
acquiescence therein, or of or in any similar breach or default thereafter occurring; nor shall any
waiver of any single breach or default be deemed a waiver of any other breach or default
theretofore or thereafter occurring. Any waiver, permit, consent or approval of any kind or

SERIES 6-A PREFERRED STOCK AND

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10

 

character on the part of any party of any breach or default under this Agreement, or any
waiver on the part of any party of any provisions or conditions of this Agreement, must be in
writing and shall be effective only to the extent specifically set forth in such writing. All
remedies, either under this Agreement or by law or otherwise afforded to any party, shall be
cumulative and not alternative.

     8.11 Acknowledgement. Each party hereto acknowledges that: (a) it has read this
Agreement; (b) it has been represented in the preparation, negotiation and execution of this
Agreement by legal counsel of its own choice or has voluntarily declined to seek such counsel; and
(c) it understands the terms and consequences of this Agreement and is fully aware of the legal and
binding effect of this Agreement.

     8.12 Entire Agreement. This Agreement (including the Exhibits hereto) constitutes the
full and entire understanding and agreement among the parties with respect to the subject matter
hereof, and any other written or oral agreement relating to the subject matter hereof existing
among the parties is expressly canceled.

[SIGNATURE PAGES FOLLOW]

SERIES 6-A PREFERRED STOCK AND

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     IN WITNESS WHEREOF, the parties have executed this Series 6-A Preferred Stock and Warrant
Purchase Agreement as of the Effective Date.

	 	 	 	 	 	 	 
	 	 	COMPANY:	 	 
	 
	 	 	 	 	 	 
	 	 	TRI-ISTHMUS GROUP, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

DAVID HIRSCHHORN, CEO
	 	 
	 
	 	 	 	 	 	 
	 	 	Address:	 	 
	 
	 	 	 	 	 	 
	 	 	9663 Santa Monica Blvd., #959	 	 
	 	 	Beverly Hills, California 90210	 	 

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

1

 

[Purchaser Signature Page]

	 	 	 	 	 	 	 
	 	 	PURCHASER:	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

	 	 
	 
	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	 	 	 

	 	 
	 
	 	 	 	 	 	 
	 	 	Company name (if applicable):	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	Title (if applicable):	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	Address:	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 

SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

2

 

EXHIBIT A

Form of Warrant

(See Attached)

EXHIBIT A TO SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

A-1

 

EXHIBIT B

Form of Certificate of Designation

(See Attached)

EXHIBIT B TO SERIES 6-A PREFERRED STOCK AND

WARRANT PURCHASE AGREEMENT

B-1

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