Document:

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Exhibit
4.3

EXECUTION
VERSION

AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT

          THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as
of this 16th day of November, 2007, by and among:

Molecular Insight Pharmaceuticals, Inc., a Massachusetts corporation
(the “Company”), the former holders (the “Series A
Holders”) of the Series A Convertible Preferred Stock, par value
$0.01 per share, of the Company (the “Series A Preferred
Stock”) set forth on Schedule A attached hereto;

The former holders (the “Series B Holders”) of the Series B
Convertible Preferred Stock, par value $0.01 per share, of the Company
(the “Series B Preferred Stock”) set forth on Schedule
B attached hereto;

The former holders (the “Series C Holders” and together with
the Series A Holders and the Series B Holders, the “Preferred
Holders”) of the Series C Convertible Preferred Stock, par value
$0.01 per share, of the Company (the “Series C Preferred
Stock”) set forth on Schedule C attached hereto;

The former holders (the “Note Holders”) of those certain
Convertible Promissory Notes in aggregate principal amount of
$15,400,000.00 and dated March 29, 2005 set forth on Schedule
D attached hereto; and

The Bond Warrant Holders (as defined below and together with the
Series A Holders, the Series B Holders, the Series C Holders, the
Common Holders and the Note Holders, each, an “Investor” and
collectively, the “Investors”) of those certain Bond Warrants
and dated of even date herewith set forth on Schedule E
attached hereto.

RECITALS:

          A. Pursuant to the terms of a certain Stock Purchase Agreement dated March 29, 2005 by and
among the Company, Cerberus Partners, L.P. and Medcap Partners, L.P., as the lead investors, and
the other Series C Holders signatory thereto (as amended, restated, supplemented or otherwise
modified to date, the “Stock Purchase Agreement”), the Company issued to the Series C
Holders an aggregate of up to 148,515 shares (the “Series C Preferred Shares”) of its
Series C Preferred Stock; and

          B. Pursuant to the Stock Purchase Agreement, the parties entered into this Agreement to set
forth, among other things, the rights of the Investors with respect to the registration of shares
of Common Stock held by and issued to the Preferred Holders upon the prior conversion of the Series
A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock (the “Preferred
Stock”); and

          C. The Company and the Note Holders entered into a Securities Purchase Agreement dated
September 28, 2006 (the “Securities Purchase Agreement”) pursuant to which, among other
things, the Company issued Notes and Warrants to each Note Holder and, as a condition to the
issuance of such securities, the parties entered into this Agreement to set forth, among other
things, the rights of the Note Holders with respect to the registration of shares of Common Stock
held by and issued to the Note Holders upon the prior conversion of the Notes and held by and
issuable to the Note Holders

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upon the exercise of Warrants issued to each Note Holder pursuant to the Securities Purchase
Agreement; and

          D. The Company has issued Bond Warrants in connection with that certain Purchase Agreement of
even date herewith (the “Purchase Agreement”) to each Bond Warrant Holder and, as a
condition to the issuance of such securities, the parties hereto desire to enter into this
Agreement to set forth, among other things, the rights of the Bond Warrant Holders with respect to
the registration of shares of Common Stock issuable to the Bond Warrant Holders upon the exercise
of Bond Warrants issued to each Bond Warrant Holder pursuant to the Purchase Agreement; and

          E. The Company previously effected the Initial Public Offering, pursuant to which all shares
of Preferred Stock and all Notes were converted into shares of Common Stock so that the Preferred
Stock and the Notes are no longer outstanding but the rights available to such Preferred Holders
and Note Holders pursuant to this Agreement remain in effect.

          NOW, THEREFORE, in consideration of the foregoing and the respective covenants hereinafter set
forth, and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the Company and each Investor, severally and not jointly, hereby agree as
follows:

Article I Definitions.

     1.1 General Definitions. As used in this Agreement, unless the context otherwise
requires, the following terms shall have the respective meanings set forth below:

          “Affiliate” means, with respect to any Person, any other Person which directly or
indirectly Controls, is Controlled by, or is under common Control with, such Person.
Notwithstanding the foregoing, none of the Company, its owners, officers, directors, employees,
agents or advisors (or any of their family members) shall be deemed an “Affiliate” of a Preferred
Holder, Note Holder or Bond Warrant Holder, unless any such Person is otherwise (i.e., independent
of the Company) an Affiliate of such Preferred Holder, Note Holder or Bond Warrant Holder.

          “Agreement” shall have the meaning ascribed to it in the preamble to this Agreement.

          “Articles of Organization” means the Company’s Articles of Organization as in effect
and as amended, supplemented, restated or otherwise modified from time to time.

          “Board” means the Board of Directors of the Company.

          “Bond Warrant” shall mean any of those certain common stock warrants issued by the
Company to the initial holders of beneficial interests in the Bonds (as defined in the Indenture)
pursuant to which such holder (or any successor holder of such warrants) may acquire Common Stock
of the Company.

          “Bond Warrant Demand Registration” shall have the meaning ascribed to it in
Section 2.1(a)(iv).

          “Bond Warrant Holder” shall mean the holder of any Bond Warrant.

          “Bond Warrant Stock” shall mean any shares of Common Stock issued or issuable by the
Company to any Bond Warrant Holder upon the exercise of any Bond Warrant.

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          “Business Day” means a day, other than a Saturday or Sunday, on which banks in New
York, New York are open for the general transaction of business.

          “Cerberus” means Cerberus Capital Management, L.P., for itself and/or one or more of
its Affiliates and/or accounts managed by Cerberus Capital Management, L.P., including, without
limitation, Cerberus Partners, L.P.

          “Control” means the possession, direct or indirect, of the power to direct or cause
the direction of the management and policies of a Person, whether through the ownership of voting
securities, by contract or otherwise.

          “Co-Lead Investors” means Cerberus Partners, L.P. and MedCap Partners, L.P.

          “Commission” means the U.S. Securities and Exchange Commission or any other successor
federal agency then administering the Securities Act and other federal securities laws.

          “Common Stock” means the common stock, par value $.01 per share, of the Company, and
any other securities into which or for which such Common Stock may be converted or exchanged
pursuant to a plan of recapitalization, reorganization, merger, consolidation, sale of assets or
other similar transaction.

          “Company” shall have the meaning ascribed to it in the preamble to this Agreement.

          “Conversion Shares” means the shares of Common Stock issuable upon conversion of the
Series C Preferred Stock.

          “Exchange Act” means the Securities Exchange Act of 1934, as amended, or any successor
federal statute, and the rules and regulations of the Commission issued under such Act, as they
each may, from time to time, be in effect.

          “Highland” means Highland Capital Management, L.P., for itself and/or one or more of
its Affiliates and/or accounts managed by Highland Capital Management, L.P.

          “Indenture” means the Indenture, dated as of November 16, 2007, among Molecular
Insight Pharmaceuticals, Inc. and The Bank of New York Trust Company, N.A., as Trustee.

          “Initial Public Offering” means the Company’s first underwritten public offering of
its Common Stock pursuant to a Registration Statement declared effective as of February 1, 2007.

          “Initiating Stockholders” means the Investor(s) who cause a Demand Notice to be
delivered pursuant to Section 2.1.

          “Investor(s)” shall have the meaning ascribed to it in the preamble to this Agreement.

          “Note” shall mean any of those certain Convertible Promissory Notes issued by the
Company to a Note Holder in an aggregate principal amount of $15,400,000.00 pursuant to the
Securities Purchase Agreement.

          “Note Demand Registration” shall have the meaning ascribed to it in Section
2.1(a)(iii).

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          “Note and Warrant Stock” shall mean any shares of Common Stock issued or issuable by
the Company to any Note Holder or Warrant Holder upon the conversion of any Note or upon the
exercise of any Warrant, as the case may be.

          “Other Stockholders” shall have the meaning ascribed to it in Section 2.1(d).

          “Person” means an individual, corporation, partnership, limited liability company,
trust, business trust, association, joint stock company, joint venture, sole proprietorship,
unincorporated organization, governmental authority or any other form of entity not specifically
listed herein..

          “Preferred Holders” shall have the meaning ascribed to it in the preamble to this
Agreement.

          “Preferred Stock” shall have the meaning ascribed to it in the recitals to this
Agreement.

          “Prospectus” shall mean the prospectus included in any Registration Statement, as
amended or supplemented by any prospectus supplement, with respect to the terms of the offering of
any portion of the Registrable Securities covered by such Registration Statement and by all other
amendments and supplements to the prospectus, including post-effective amendments and all material
incorporated by reference in such prospectus.

          “Purchase Agreement” shall have the meaning ascribed to it in the recitals to this
Agreement.

          “Register,” “registered” and “registration” refer to a registration
made by preparing and filing a Registration Statement or similar document in compliance with the
Securities Act, and the declaration or ordering of effectiveness of such Registration Statement or
document.

          “Registering Stockholder” shall mean any Preferred Holder, Note Holder, Bond Warrant
Holder and any Other Stockholder that participates in any Registration pursuant to Section 2
hereof, including any Initiating Stockholder.

          “Registrable Securities” means: (i) the shares of Common Stock issued upon the
conversion of the Preferred Stock; (ii) any Note and Warrant Stock, (iii) any Bond Warrant Stock,
(iv) any and all shares of Common Stock issued or issuable in respect of the Warrants or the Bond
Warrants upon any stock split, reverse stock split, stock dividend, recapitalization,
reorganization, merger, consolidation, sale of assets or similar event; (iv) the shares of Common
Stock previously issued as payment-in-kind dividends on the Preferred Stock; and (v) any other
shares of Common Stock acquired by any of the Investors at any time. Notwithstanding the
foregoing, the term “Registrable Securities” shall not include any shares which have been (w) sold
to or through a broker or dealer or underwriter in a public distribution or a public securities
transaction, (x) sold in a transaction exempt from the registration and prospectus delivery
requirements of the Securities Act under Section 4(1) thereof so that all transfer restrictions and
restrictive legends with respect thereto are removed upon the consummation of such sale, (y)
registered under the Securities Act pursuant to an effective Registration Statement filed
thereunder or (z) publicly sold pursuant to Rule 144 under the Securities Act.

          “Registration Statement” means a Registration Statement filed by the Company with the
Commission for a public offering and sale of securities of the Company (other than a Registration
Statement on Form S-8 or Form S-4, or their successors, or any other form for a similar limited
purpose, or any Registration Statement covering only securities proposed to be issued in exchange
for securities or assets of another corporation).

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          “Requisite Bond Warrant Holders” shall mean (i) Highland and (ii) the holders of a
majority in principal amount of the outstanding Bond Warrants.

          “Requisite Note Holders” shall mean (i) Cerberus and (ii) the holders of a majority of
the Common Stock then issued and outstanding but not registered, which were issued upon conversion
of the Notes (excluding for this purpose the shares of Common Stock held by Cerberus).

          “Requisite Series AB Holders” means the holders of at least a majority of the Common
Stock then issued and outstanding but not registered, which were issued upon conversion of the
Series A Preferred Stock and Series B Preferred Stock.

          “Requisite Series C Holders” means Cerberus and Series C Holders holding at least a
majority of the Common Stock then issued and outstanding but not registered, which were issued upon
conversion of the Series C Preferred Stock.

          “Securities Act” means the Securities Act of 1933, as amended, or any successor
federal statute, and the rules and regulations of the Commission issued under such Act, as they
each may, from time to time, be in effect.

          “Series A Holders” shall have the meaning ascribed to it in the preamble to this
Agreement.

          “Series A Preferred Stock” shall have the meaning ascribed to it in the preamble to
this Agreement.

          “Series AB Demand Registration” shall have the meaning ascribed to it in Section
2.1(a)(ii).

          “Series AB Holders” means the Series A Holders and the Series B Holders.

          “Series B Holders” shall have the meaning ascribed to it in the preamble to this
Agreement.

          “Series B Preferred Stock” shall have the meaning ascribed to it in the preamble to
this Agreement.

          “Series C Demand Registration” shall have the meaning ascribed to it in Section
2.1(a)(i).

          “Series C Holders” shall have the meaning ascribed to it in the preamble to this
Agreement.

          “Series C Preferred Stock” shall have the meaning ascribed to it in the preamble to
this Agreement.

          “Warrant” shall mean those certain Common Stock Warrants issued by the Company to the
Note Holders pursuant to the Securities Purchase Agreement pursuant to which each Note Holder may
acquire Common Stock of the Company.

          “Warrant Holder” shall mean the holder of any Warrant.

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Article II  Registration Rights.

     2.1  Demand Registration.

          (a) At any time by delivery of written notice to the Company (a “Demand Notice”):

               (i) the Requisite Series C Holders may require the Company to register for sale under the
Securities Act all or any portion of the Registrable Securities held by the Series C Holders for
sale in the manner specified in such Demand Notice (a “Series C Demand Registration”). The
Requisite Series C Holders shall be entitled to only two (2) Series C Demand Registrations pursuant
to this Section 2.1(a)(i); provided, that, they may only make demand for
one such Series C Demand Registration in any twelve month period, unless any of them shall have had
any Registrable Securities excluded from a Registration Statement that was filed during such twelve
month period; and

               (ii) the Requisite Series AB Holders may require the Company to register for sale under the
Securities Act all or any portion of the Registrable Securities held by the Series AB Holders for
sale in the manner specified in such Demand Notice; provided, that (i) the portion
of the Registrable Securities required to be so registered equals at least 25% of the shares of
Common Stock issuable upon conversion of the shares of Series A Preferred Stock and Series B
Preferred Stock then outstanding and (ii) the aggregate proceeds from the sale of the shares so
registered is reasonably expected to exceed $30,000,000 (a “Series AB Demand
Registration”). The Requisite Series AB Holders shall be entitled to only two (2) Series AB
Demand Registrations pursuant to this Section 2.1(a)(ii); provided, that,
they may only make demand for one such Series AB Demand Registration in any twelve month period,
unless any of them shall have had any Registrable Securities excluded from a Registration Statement
that was filed during such twelve month period; and

               (iii) The Requisite Note Holders may require the Company to register for sale under the
Securities Act all or any portion of the Registrable Securities held by the Note Holders for sale
in the manner specified in such Demand Notice (a “Note Demand Registration”). The
Requisite Note Holders shall be entitled to only two (2) Note Demand Registrations pursuant to this
Section 2.1(a)(iii); provided, that, they may only make demand for one such
Note Demand Registration in any twelve month period, unless any of them shall have had any
Registrable Securities excluded from a Registration Statement that was filed during such twelve
month period;

               (iv) The Requisite Bond Warrant Holders may require the Company to register for sale under the
Securities Act all or any portion of the Registrable Securities held by the Bond Warrant Holders
for sale in the manner specified in such Demand Notice (a “Bond Warrant Demand
Registration”); provided, however, that a Bond Warrant Demand Registration may
not be made within 180 days after the date hereof. The Requisite Bond Warrant Holders shall be
entitled to only two (2) Bond Warrant Demand Registrations pursuant to this Section 2.1(a)(iv),
except as provided in Section 2.1(a)(v); provided, that, they may only make
demand for one such Bond Warrant Demand Registration in any twelve month period, unless any of them
shall have had any Registrable Securities excluded from a Registration Statement that was filed
during such twelve month period; and

               (v) if the Company is then a registrant entitled to use Form S-3 or any successor form thereto
to effect the distribution of such Registrable Securities for public sale or re-sale (as the case
may be), (aa) the Requisite Series C Holders may require the Company to register for sale or
re-sale under the Securities Act by filing a Registration Statement on Form S-3 or any comparable
or successor form thereto for a public offering of all or any portion of the Registrable Securities
held by them, (bb) the Requisite Series AB Holders may require the Company to register for sale or
re-sale under

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the Securities Act by filing a Registration Statement on Form S-3 or any comparable or
successor form thereto for a public offering of all or any portion of the of Registrable Securities
held by them, (cc) the Requisite Note Holders may require the Company to register for sale or
re-sale under the Securities Act by filing a Registration Statement on Form S-3 or any comparable
or successor form thereto for a public offering of all or any portion of the Registrable Securities
held by them, in each case, in accordance with the method of disposition specified in the Demand
Notice and (dd) the Requisite Bond Warrant Holders may require the Company to register for sale or
re-sale under the Securities Act by filing a Registration Statement on Form S-3 or any comparable
or successor form thereto for a public offering of all or any portion of the Registrable Securities
held by them, in each case, in accordance with the method of disposition specified in the Demand
Notice. Whenever the Company is required by this Section 2.1(a)(v) to effect the
registration of Registrable Securities, each of the procedures and requirements of Sections 2.1
and 2.4 shall apply to such registration, and the Company shall cause such Registration
Statement to be declared effective within one hundred eighty (180) days after the Company’s receipt
of the request for such registration. There shall be no limitation on the number of registrations
on Form S-3 which may be requested and obtained under this Section 2.1, and such requests
and registrations shall not reduce the number of Series C Demand Registrations, Series AB Demand
Registrations, Note Demand Registrations, or Bond Warrant Demand Registrations, as the case may be,
to which the Series C Holders, Series AB Holders, Note Holders or Bond Warrant Holders, as the case
may be, are entitled hereunder.

          (b) Following receipt of any Demand Notice under this Section 2.1, the Company shall
file a Registration Statement including the securities covered by such Demand Notice within thirty
(30) days after receipt of such Demand Notice (the “Filing Deadline”), and the Company
shall use its best efforts to effect the registration under the Securities Act as soon as
practicable, and in any event within one hundred eighty (180) days after receipt of such Demand
Notice (the “Effectiveness Deadline”), for public sale or re-sale in accordance with the
method of disposition specified in such Demand Notice of the number of Registrable Securities
specified in such Demand Notice. If a Registration Statement including the Registrable Securities
referenced in the Demand Notice is not (i) filed with the Commission on or prior to the applicable
Filing Deadline, or (ii) declared effective by the applicable Effectiveness Deadline, then the
Company shall make pro rata payments to each Investor whose securities are to be included in such
Registration Statement, as liquidated damages (and not as a penalty, as damages are impossible to
forecast or predict and these amounts are deemed reasonable in all respects), in an amount equal to
1.5% of the aggregate Market Price (as defined in the Articles of Organization) (as of the Filing
Deadline) of the Investor’s securities to be included in such Registration Statement for each
30-day period or pro rata for any portion thereof following the date by which such Registration
Statement should have been filed or declared effective, as the case may be, for which no
Registration Statement is filed or has not been declared effective, as the case may be, with
respect to the Registrable Securities. Such payments shall be in partial compensation to the
Investors, and shall not constitute the Investors’ exclusive remedy for such events. Such payments
shall be made to each Investor in cash. The amounts payable as liquidated damages pursuant to this
Section 2.1(b) shall be payable in lawful money of the United States, and amounts payable
as liquidated damages shall be paid within two (2) Business Days of the last day of each such
30-day period (or portion thereof if less than a full 30-day period) during which the Registration
Statement should have been filed or been declared effective, as the case may be, for which no
Registration Statement was filed or had not yet been declared effective, as the case may be, with
respect to the Registrable Securities. In the event the Company fails to make such payments in a
timely manner, such payments shall bear interest at the rate of 1.5% per 30-day period (prorated
for partial periods) until paid in full.

          (c) If the Initiating Stockholders intend to distribute the Registrable Securities covered by
their Demand Notice by means of an underwriting, the Initiating Stockholders shall so advise the
Company in their Demand Notice. If the method of disposition is an underwritten public offering,
the Initiating Stockholders may designate the managing underwriter of such offering, which
designation shall

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be subject to the Company’s approval, not to be unreasonably withheld. The Initiating
Stockholders may elect to include in such underwriting all or any part of the Registrable
Securities it holds, subject to the limitations required by the managing underwriter as provided
for in Section 2.1(d).

          (d) A Registration Statement filed pursuant to this Section 2.1 may, subject to the
following provisions and in addition to the Registrable Securities, include (i) shares of Common
Stock for sale by the Company for its own account; (ii) shares of Common Stock held by the
Requisite Series C Holders, the Requisite Note Holders and Requisite Bond Warrant Holders who are
not Initiating Stockholders (the “Non-Initiating Stockholders”); and (iii) shares of Common
Stock held by persons other than the Company, the Preferred Holders, the Note Holders and Bond
Warrant Holders (the “Other Stockholders”), in each case for sale in accordance with the
method of disposition specified by the Initiating Stockholders and subject to the exclusions
provided herein. If such registration shall be underwritten, the Company, the Preferred Holders,
the Note Holders, the Bond Warrant Holders and the Other Stockholders proposing to distribute their
shares through such underwriting shall enter into an underwriting agreement in customary form with
the representative of the underwriter or underwriters selected for such underwriting (the terms of
which shall not be more favorable to the Company, the Non-Initiating Stockholders, and such Other
Stockholders than the terms afforded therein to the Initiating Stockholders); provided, however,
that no Registering Stockholder shall be required to make any representations or warranties, or
provide any indemnity, in connection with any such Registration other than representations and
warranties (or indemnities with respect thereto) as to (A) such Registering Stockholder’s ownership
of its securities to be transferred pursuant to such underwriting agreement free and clear of all
liens, claims and encumbrances, (B) such Registering Stockholder’s power and authority to effect
the sale of such securities pursuant to such underwriting agreement, (C) such matters pertaining to
compliance with securities laws by such Registering Stockholder as may be reasonably requested by
the representative of the underwriter or underwriters and (D) such matters relating to written
information furnished to the Company by such Registering Stockholder specifically for use in the
registration statement and prospectus (and any related documents) to be used by the Company in
connection with such Registration; provided further, however, that the
obligation of such Registering Stockholder to indemnify any Person pursuant to any such
underwriting agreement shall be several, not joint and several, among the Registering Stockholders
selling securities in such Registration, and the liability of each such Registering Stockholder
will be in proportion thereto; and provided further, however, that such
liability will be limited to the net amount (after giving effect to underwriters discounts and
commissions) received by such Registering Stockholder from the sale of its securities pursuant to
such Registration. If and to the extent that the managing underwriter determines that marketing
factors require a limitation on the number of shares to be included in such registration, then the
shares of Common Stock sought to be registered by the Preferred Holders, the Note Holders, the Bond
Warrant Holders and the Other Stockholders and shares of Common Stock to be sold by the Company for
its own account shall be excluded from such registration to the extent so required by such managing
underwriter in the following order of priority: (1st) and unless the Other Stockholders and the
Company have otherwise agreed in writing, such exclusion shall be applied first to the shares
sought to be registered by the Other Stockholders to the extent any such reduction is required by
the managing underwriter; (2nd) then to the shares of Common Stock of the Company to be included
for its own account to
 the extent any such reduction is required by the managing underwriter; (3rd)
then to the shares sought to be registered by the Non-Initiating Stockholders; (4th)
then to the shares sought to be registered by the Series AB Holders who are Initiating Stockholders
and to the extent any such reduction is required by the managing underwriter; (5th) then to the
shares sought to be registered by the Series C Holders who are Initiating Stockholders and the Note
Holders who are Initiating Stockholders, ratably between them treating them as one class for the
purpose of this clause (d), to the extent any such reduction is required by the managing
underwriter; and (6th) then to the shares sought to be registered by the Bond Warrant Holders who
are Initiating Stockholders, to the extent any such reduction is required by the managing
underwriter. In any event, all securities to be sold other than Registrable Securities of the
Series C Holders, the Note Holders and Bond Warrant Holders shall be

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excluded prior to any exclusion of Registrable Securities of the Series C Holders, the Note
Holders and Bond Warrant Holders, if they are participating in such registration, whether or not
they are the Initiating Stockholders with respect to such registration. No Registrable Securities
or other securities, in either case, excluded from the underwriting by reason of the underwriter’s
marketing limitation shall be included in such registration. If any of the Preferred Holders, Note
Holders, Bond Warrant Holders or any of the Other Stockholders who has requested inclusion in such
registration as provided above, disapproves of the terms of the underwriting, then such Preferred
Holder(s), Note Holder(s), Bond Warrant Holder(s) or such Other Stockholder(s) may elect to
withdraw therefrom by written notice to the Company and the managing underwriter. The securities
so withdrawn shall thereupon be withdrawn from registration. If the Initiating Stockholder elects
to withdraw from such Registration, the initiation of such Registration shall not count as a demand
registration by such Initiating Stockholder for purposes hereof.

          (e) The Company may delay or postpone for up to 45 consecutive days effecting a Series AB,
Series C Demand Registration, Note Demand Registration or Bond Warrant Demand Registration if the
Company has delivered a written certificate to each Investor stating that the Board, acting in good
faith, has resolved that pursuit of such demand registration during such 45-day period would have a
material adverse effect on the Company and its shareholders; provided, however,
that in the event of any such postponement, the Initiating Stockholders shall be entitled to
withdraw the request for such demand registration and, if such request is withdrawn, such request
shall not count as a demand registration hereunder; and provided, further, that the
Company may not exercise its rights under this Section 2.1(e) for more than a total of 60
days in any eighteen month period.

     2.2 Piggy-Back Registration.

          (a) If the Company at any time proposes to register any of its securities under the Securities
Act for sale to the public, whether for its own account or for the account of other shareholders of
the Company or both (except with respect to (i) an Initial Public Offering, (ii) Registration
Statements on Forms S-4, S-8 or any successor to such forms, (iii) any Registration Statement
including only securities issued pursuant to a dividend reinvestment plan, (iv) a Registration
Statement in which the only securities to be registered are securities issuable upon conversion of
debt securities or other convertible securities which are also being registered or (v) another form
of Registration Statement not available for registering the Registrable Securities for sale to the
public), each such time the Company shall promptly give written notice to the Preferred Holders,
the Note Holders and the Bond Warrant Holders of its intention to do so (each, a “Piggy-Back
Notice”). Upon the written request of the Requisite Series C Holders, Requisite Note Holders
and/or Requisite Bond Warrant Holders, received by the Company within twenty (20) days after the
date of delivery of a Piggy-Back Notice, in accordance with Section 3.4, to register any or
all of the Registrable Securities held by the Series C Holders, Note Holders and/or Bond Warrant
Holders as stated in such request, the Company shall use its best efforts to cause the Registrable
Securities as to which registration shall have been so requested to be included in such
Registration Statement. If the Registration Statement relates to an underwritten public offering,
the Company shall so advise the Preferred Holders, the Note Holders and Bond Warrant Holders as a
part of a Piggy-Back Notice. In such event, the Preferred Holders’, Note Holders’ and Bond Warrant
Holders’ right to include Registrable Securities in such registration shall be conditioned upon its
participation in such underwriting to the extent provided herein. The Preferred Holders, the Note
Holders and Bond Warrant Holders, if participating in such distribution, shall enter into an
underwriting agreement in customary form with the underwriter or underwriters selected for
underwriting by the Company (but if the Registration Statement was initiated by an Initiating
Stockholder, such underwriter shall be selected by such Initiating Stockholder, subject to the
Company’s approval, not to be unreasonably withheld), the terms of which shall be no less favorable
to the Preferred Holders, the Note Holders and the Bond Warrant Holders than the terms afforded
therein to the Company, provided, however, that no Registering Stockholder shall be required to
make any representations or warranties, or provide any indemnity, in connection with any such

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Registration other than representations and warranties (or indemnities with respect thereto)
as to (A) such Registering Stockholder’s ownership of its securities to be transferred pursuant to
such underwriting agreement free and clear of all liens, claims and encumbrances, (B) such
Registering Stockholder’s power and authority to effect the sale of such securities pursuant to
such underwriting agreement, (C) such matters pertaining to compliance with securities laws by such
Registering Stockholder as may be reasonably requested by the representative of the underwriter or
underwriters and (D) such matters relating to written information furnished to the Company by such
Registering Stockholder specifically for use in the registration statement and prospectus (and any
related documents) to be used by the Company in connection with such Registration; provided
further, however, that the obligation of such Registering Stockholder to indemnify
any Person pursuant to any such underwriting agreement shall be several, not joint and several,
among the Registering Stockholders selling securities in such Registration, and the liability of
each such Registering Stockholder will be in proportion thereto; and provided
further, however, that such liability will be limited to the net amount (after
giving effect to underwriters discounts and commissions) received by such Registering Stockholder
from the sale of its securities pursuant to such Registration.

          (b) Notwithstanding any other provision of this Section 2.2, if the managing
underwriter or underwriters in the registration giving rise to the Piggy-Back Notice (other than a
demand registration pursuant to Section 2.1) determine(s) that the number of shares to be
included in such registration (including any securities that the Company and the Other
Stockholders propose to be included that are not Registrable Securities) exceeds the largest number
of shares that can be sold without having an adverse effect on such offering (the “Maximum
Offering Size”), the Company will include in such registration, in the following priority, up
to the Maximum Offering Size:

               (i) first, that number of securities proposed to be registered by the Company if the Company
has initiated such registration;

               (ii) second, subject to Section 2.2(c) below, if the Maximum Offering Size has not
been exceeded pursuant to clause (i) in connection with a registration initiated by the Company,
that number of securities proposed to be registered for the account of the Bond Warrant Holders,
ratably between them treating them as one class for the purpose of this clause (ii);

               (iii) third, subject to Section 2.2(c) below, if the Maximum Offering Size has not
then been exceeded, that number of securities proposed to be registered for the account of the
Series C Holders and the Note Holders, ratably between them treating them as one class for the
purpose of this clause (iii);

               (iv) fourth, if the Maximum Offering Size has not then been exceeded, that number of
securities proposed to be registered for the account of the Series A and Series B Preferred Stock,
ratably between them treating them as one class for the purpose of this clause (iv);

               (v) fifth, if the Maximum Offering Size has not then been exceeded, that number of securities
proposed to be registered by the Company for its own account if the Company did not initiate such
registration; and

               (vi) sixth, if the Maximum Offering Size has not then been exceeded, any securities proposed
to be registered for the account of any other Persons (other than the Company and those Persons
described in clauses (ii), (iii) and (iv) immediately above) with such priorities among them as the
Company shall determine.

10

 

          (c) Notwithstanding the foregoing in Section 2.2(b), other than in the case of
offerings initiated by the Company, in no event shall the number of securities proposed to be
registered for the account of the Bond Warrant Holders, Series C Holders and the Note Holders
pursuant to Section 2.2(b)(ii) and (iii) above be reduced below thirty percent
(30%) of the total number of securities included in such registration.

          (d) Any request by a Preferred Holder, Note Holder or Bond Warrant Holder for inclusion in any
registration may be withdrawn, in whole or in part, at any time prior to the effective date of the
Registration Statement for such offering. No request for inclusion of, nor the inclusion of,
Registrable Securities by a Series C Holder, Note Holder or Bond Warrant Holder shall be deemed a
Series C Demand Registration, Note Demand Registration or Bond Warrant Demand Registration, as the
case may be, that reduces the number of such Series C Demand Registrations, Note Demand
Registrations or Bond Warrant Demand Registrations, as the case may be, to which the Series C
Holders, Note Holders or Bond Warrant Holders, as the case may be, are entitled hereunder.

          (e) The Company shall have the right to terminate or withdraw any registration contemplated
under this Section 2.2 prior to the effectiveness of such registration, whether or not the
Series C Holders, Note Holders or Bond Warrant Holders, as the case may be, have elected to include
securities in such registration.

          (f) There shall be no limitation on the number of registrations a Preferred Holder, Note
Holder or Bond Warrant Holder may participate in under this Section 2.2, and any such
participation shall not reduce the number of Series C Demand Registrations, Note Demand
Registrations or Bond Warrant Demand Registrations, as the case may be, to which the Series C
Holders, Note Holders and Bond Warrant Holders, respectively, are entitled hereunder.

     2.3 Limitation on Registration. Notwithstanding anything herein to the contrary, the
Company shall not be required to file a Registration Statement pursuant to Section 2.1 that
would: (i) require the Company to execute a general consent to service of process in any
jurisdiction in order to effect such registration if the Company is not already subject to service
in such jurisdiction, or (ii) subject the Company to taxation in a jurisdiction where the Company
is not otherwise subject to taxation.

     2.4 Registration Procedures. If and whenever the Company is required by the
provisions of Section 2.1 or 2.2 to effect the registration of any Registrable Securities
under the Securities Act, the Company shall, as expeditiously as possible:

          (a) Prepare and file with the Commission a Registration Statement on the applicable form with
respect to such securities and use its best efforts to cause such Registration Statement to become
and remain effective until the earlier of (i) the sale of all of the Registrable Securities covered
thereby and (ii) the first date when all Registrable Securities covered thereby are eligible for
sale under Rule 144(k) (or any successor rule) without regard to any volume or manner of sale
limitations; provided, however, that, as soon as practicable but in no event later
than five (5) Business Days before filing such Registration Statement, any related prospectus or
any amendment or supplement thereto (other than any amendment or supplement made solely as a result
of incorporation by reference of documents filed with the Commission subsequent to the filing of
such Registration Statement), the Company shall furnish to the Preferred Holders, the Note Holders,
the Bond Warrant Holders and the underwriters, if any, copies of all such documents proposed to be
filed, which documents shall be subject to review by the Preferred Holders, Note Holders, Bond
Warrant Holders and any such underwriters; the Company shall not file any Registration Statement or
amendment thereto or any prospectus or any supplement thereto (other than any amendment or
supplement made solely as a result of incorporation by reference of documents filed with the
Commission subsequent to the filing of such Registration Statement) to which the managing

11

 

underwriters of the applicable offering, if any, or either of the Co-Lead Investors or
Highland shall have reasonably objected in writing, within four (4) Business Days after receipt of
such documents, to the effect that such Registration Statement or amendment thereto or prospectus
or supplement thereto does not comply in all material respects with the requirements of the
Securities Act and specifying in reasonable detail the reasons therefor (provided that the
foregoing shall not limit a Preferred Holder’s, Note Holder’s or Bond Warrant Holder’s right to
reasonably object, within four (4) Business Days after receipt of such documents, to any particular
information that is to be contained in such Registration Statement, amendment, prospectus or
supplement and relates specifically to such Preferred Holder, Note Holder and/or Bond Warrant
Holder, as the case may be, including without limitation any information describing the manner in
which the Preferred Holder, Note Holder or Bond Warrant Holder acquired such Registrable Securities
and the intended method of distribution of such Registrable Securities), and if the Company is
unable to file any such document due to the objections of such underwriters or either of the
Co-Lead Investors or Highland, the Company shall use its best efforts to cooperate with such
underwriters and each of the Co-Lead Investors and Highland to prepare, as soon as practicable, a
document that is responsive in all material respects to the reasonable objections of any of the
Co-Lead Investors and Highland;

          (b) Permit a single law firm designated by the Co-Lead Investors to represent all of the
Series C Holders, a single law firm designated by the Requisite Note Holders to represent all of
the Note Holders, a single law firm designated by the Requisite Bond Warrant Holders to represent
all of the Bond Warrant Holders and a single law firm designated by the Requisite Series AB Holders
to represent the Series AB Holders, to review and comment on the Registration Statement which
includes their respective Registrable Securities and all amendments and supplements for a
reasonable period prior to filing and to respond to any reasonable objections raised by such
counsel;

          (c) Prepare and file with the Commission such amendments and supplements to such Registration
Statement and the prospectus used in connection therewith as may be necessary to keep such
Registration Statement effective for the period specified herein and comply with the provisions of
the Securities Act with respect to the disposition of all Registrable Securities covered by such
Registration Statement in accordance with the intended method of disposition set forth in such
Registration Statement for such period; provided, that, the Company shall comply
with the provisions of Section 2.4(a) above;

          (d) Furnish to the Preferred Holders, the Note Holders, the Bond Warrant Holders and to each
underwriter copies of the Registration Statement and each such amendment and supplement thereto
(together with all exhibits thereto) and the prospectus included therein and any other prospectus
filed under Rule 424 or Rule 434 (or any successor rule) under the Securities Act as the Preferred
Holders, the Note Holders, the Bond Warrant Holders and such underwriter reasonably may request in
order to facilitate the disposition of the Registrable Securities covered by such Registration
Statement;

          (e) Use its best efforts to register or qualify the Registrable Securities covered by such
Registration Statement under the securities or “blue sky” laws of such jurisdictions as the sellers
of the Registrable Securities or, in the case of an underwritten public offering, the managing
underwriter reasonably shall request; provided, however, that the Company shall not
be required to (i) qualify to transact business as a foreign corporation in any jurisdiction where
it is not so qualified, (ii) consent to general service of process in effecting such Registration,
unless the Company is already subject to service of process in such jurisdiction or (iii) submit to
taxation in any such jurisdiction, unless the Company is already subject to service or subject to
taxation in such jurisdiction;

          (f) Use its best efforts to list or qualify the Registrable Securities covered by such
Registration Statement on any securities exchange or quotation system on which the Common Stock is

12

 

then listed or if they are not so listed, on such exchanges as the Initiating Stockholders may
reasonably request;

          (g) Comply in all material respects with all applicable rules and regulations under the
Securities Act and Exchange Act;

          (h) Immediately notify the Preferred Holders, the Note Holders, the Bond Warrant Holders and
each underwriter under such Registration Statement, at any time when a prospectus relating thereto
is required to be delivered under the Securities Act, of the happening of any event which has
resulted or would result in the prospectus contained in such Registration Statement, as then in
effect, to include an untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary to make the statements therein, in light of the circumstances
under which they were made, not misleading, and promptly prepare and furnish to such Investor and
underwriter an updated prospectus;

          (i) If the offering is underwritten, and at each Preferred Holder’s, Note Holder’s and Bond
Warrant Holder’s request, use its best efforts to furnish on the date that Registrable Securities
are delivered to the underwriters for sale pursuant to such registration (i) an opinion, dated such
date, of counsel to the Company, addressed to the underwriters, the Preferred Holders, the Note
Holders and the Bond Warrant Holders, to such effect as reasonably may be requested by the
underwriters, and (ii) a letter, dated such date, from the independent public accountants retained
by the Company, addressed to the underwriters and, if applicable, the Preferred Holders, the Note
Holders and the Bond Warrant Holders, stating that they are independent public accountants within
the meaning of the Securities Act and that, in the opinion of such accountants, the financial
statements of the Company included in the Registration Statement or the prospectus, or any
amendment or supplement thereof, comply as to form in all material respects with the applicable
accounting requirements of the Securities Act, and such letter shall additionally cover such other
financial matters (including information as to the period ending no more than five (5) Business
Days prior to the date of such letter) with respect to such registration as such underwriters
reasonably may request, and deliver copies of such letter to the Investor;

          (j) For the purpose of participating in any Registration Statement, upon reasonable notice and
at reasonable times during normal business hours, make available for inspection by the Preferred
Holders, the Note Holders, the Bond Warrant Holders, any underwriter participating in any
distribution pursuant to such Registration Statement, and any attorney, accountant or other agent
retained by the Preferred Holders or the Note Holders or the Bond Warrant Holders or such
underwriter, reasonable access to all financial and other records, pertinent corporate documents
and properties of the Company, as such parties may reasonably request, and cause the Company’s
officers, directors and employees to supply all information reasonably requested by any of the
Preferred Holders, the Note Holders, the Bond Warrant Holders, such underwriter, attorney,
accountant or agent in connection with such Registration Statement; provided,
however, the Company shall neither disclose the existence or content of any material,
non-public information concerning the Company at a time when possession of such information by a
Preferred Holder, Note Holder or Bond Warrant Holder would, under applicable law, prohibit the
Preferred Holder, Note Holder or Bond Warrant Holder from trading in the Company’s securities;

          (k) Notify the Preferred Holders, the Note Holders and Bond Warrant Holders (i) when the
prospectus or any prospectus supplement or post-effective amendment has been filed, and, with
respect to such Registration Statement or any post-effective amendment, when the same has become
effective, such notice to be given no later than 9:00 a.m. (New York time) of the morning on the
Business Day immediately after the declaration of effectiveness by the Commission, (ii) immediately
of any request by the Commission for amendments or supplements
to such Registration Statement or to amend or supplement such prospectus or for additional
information, (iii) immediately of the issuance by the

13

 

Commission of any stop order suspending the effectiveness of such Registration Statement or
the initiation of any proceeding for that purpose and (iv) immediately of the suspension of the
qualification of securities covered by such registration for offering or sale in any jurisdiction,
or of the initiation of any proceeding for any of such purposes;

          (l) Take such other actions as the Preferred Holders, the Note Holders, the Bond Warrant
Holders or the underwriters reasonably request in order to expedite or facilitate the disposition
of the Registrable Securities, including, without limitation, preparing for, and participating in,
such number of “road shows” and all such other customary selling efforts as the Preferred Holders,
the Note Holders, the Bond Warrant Holders or the underwriters reasonably request in order to
expedite or facilitate such disposition;

          (m) Use its reasonable best efforts to prevent the issuance of any stop order or other
suspension of effectiveness and, if such order is issued, obtain the withdrawal of any such order
at the earliest possible moment; and

          (n) Otherwise use its reasonable best efforts to comply with all applicable rules and
regulations of the Commission under the Securities Act and the Exchange Act and take such other
actions as may be reasonably necessary to facilitate the registration of the Registrable Securities
hereunder; and make available to its security holders, as soon as reasonably practicable, but not
later than the Availability Date (as defined below), an earnings statement covering a period of at
least twelve (12) months, beginning after the effective date of each Registration Statement, which
earnings statement shall satisfy the provisions of Section 11(a) of the Securities Act (for the
purpose of this Section 2.4(n), “Availability Date” means the 45th day following
the end of the fourth fiscal quarter that includes the effective date of such Registration
Statement, except that, if such fourth fiscal quarter is the last quarter of the Company’s fiscal
year, “Availability Date” means the 90th day after the end of such fourth fiscal quarter).

     2.5 Expenses. The Company shall bear all reasonable expenses incurred in complying
with Sections 2.1, 2.2 and 2.4, including, without limitation, all
registration and filing fees, printing expenses, fees and disbursements of counsel and independent
public accountants for the Company, fees and expenses (including counsel fees) incurred in
connection with complying with state securities or “blue sky” laws, reasonable fees and
disbursements of one law firm designated by the Co-Lead Investors, one law firm designated by the
Note Holders, one law firm designated by the Bond Warrant Holders and one law firm designated by
the Series AB Holders, of transfer agents and registrars and costs of any insurance which might be
obtained by the Company with respect to the offering by the Company.

     2.6 Indemnification and Contribution.

          (a) The Company shall indemnify and hold harmless, to the fullest extent permitted by law,
each Preferred Holder, Note Holder, Bond Warrant Holder and its respective Affiliates and the
directors, officers, employees, investors, partners and agents (including lawyers and accountants)
of each Preferred Holder, Note Holder, Bond Warrant Holder and its respective Affiliates, from and
against any and all losses, claims, damages, liabilities and expenses (including without limitation
reasonable attorney fees and disbursements and other expenses incurred in connection with
investigating, preparing or defending any action, claim or proceeding, pending or threatened and
the costs of enforcement hereof) (collectively, “Losses”) to which any such Person may become
subject, arising out of or based upon any untrue statement or alleged untrue statement of a
material fact contained in any Registration Statement covering any Registrable Securities, any
related prospectus or preliminary prospectus, or any amendment or supplement thereto, or any
omission or alleged omission to state in any thereof a material fact required to be stated therein
or necessary to make the statements therein (in the case of a prospectus or prospectus
supplement, in light of the circumstances under which they were made) not misleading or any
violation by

14

 

the Company of the Securities Act, the Exchange Act or any state securities law or any
rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities
laws in connection with the offering covered by such Registration; provided, however, that the
Company will not be liable in any such case to the extent any Losses arise out of or are based upon
an untrue statement of a material fact or an omission to state a material fact in such Registration
Statement, prospectus, preliminary prospectus, amendment or supplement, as the case may be, made or
omitted, as the case may be, in express reliance upon and in strict conformity with written
information furnished to the Company by the Preferred Holder, Note Holder or Bond Warrant Holder
expressly for use therein who is requesting such indemnification. This indemnity is in addition to
any liability that the Company may otherwise have. The Company shall also indemnify any
underwriters of the Registrable Securities, selling brokers, dealer managers and similar securities
industry professionals participating in the distribution and their officers and directors and each
Person who controls such underwriters or other Persons (within the meaning of the Securities Act)
to the same extent as provided above with respect to the indemnification of the Preferred Holder,
Note Holder, Bond Warrant Holder and its respective Affiliates as described above, if so required
by the underwriting agreement entered into in connection with the registration of such Registrable
Securities.

          (b) In connection with any Registration Statement covering Registrable Securities, each
Preferred Holder, Note Holder and Bond Warrant Holder whose Registrable Securities were included in
such Registration Statement shall furnish to the Company in writing such information with respect
to the Preferred Holder, the Note Holder or Bond Warrant Holder as the Company reasonably requests
for use in connection with such Registration Statement, any related Prospectus or preliminary
prospectus, or any amendment or supplement thereto, and, severally and jointly, shall indemnify, to
the fullest extent permitted by law, the Company, the Company’s directors, officers, employees and
agents, each Person who controls the Company (within the meaning of the Securities Act), against
all Losses arising out of or based upon any untrue statement of a material fact contained in any
Registration Statement covering any Registrable Securities, any related Prospectus or preliminary
prospectus, or any amendment or supplement thereto, or any omission to state in any such
prospectus, amendment or supplement, a material fact required to be stated therein or necessary to
make the statements therein (in the case of a prospectus or prospectus supplement, in light of the
circumstances under which they were made) not misleading, in each case to the extent, and only to
the extent, that the Losses arise out of or are based upon an untrue statement of a material fact
or an omission to state a material fact in such Registration Statement or in such related
Prospectus, preliminary prospectus, amendment or supplement, as the case may be, made or omitted,
as the case may be, in express reliance upon and in strict conformity with written information
furnished to the Company by such Preferred Holder, Note Holder or Bond Warrant Holder expressly for
use therein. Notwithstanding anything in this Agreement to the contrary, in no event shall the
Preferred Holder’s, Note Holder’s or Bond Warrant Holder’s indemnification obligation exceed the
dollar amount of the net proceeds actually received (after giving effect to underwriters discounts
and commissions) by such Preferred Holder, Note Holder or Bond Warrant Holder from the sale of the
Registrable Securities under the Registration Statement giving rise to such obligation.

          (c) Promptly after receipt by any Person (the “Indemnified Person”) of notice of any
demand, claim or circumstances which would or might give rise to a claim or the commencement of any
action, proceeding or investigation in respect of which indemnity may be sought pursuant to
Section 2.6, such Indemnified Person shall promptly notify the party obligated to provide
indemnification under this Section 2.6 in respect thereof (an “Indemnifying Party”)
and the Indemnifying Party shall assume the control and defense thereof, including the employment
of counsel reasonably satisfactory to such Indemnified Person, and shall assume the payment of all
fees and expenses in connection with such defense and such counsel; provided,
however, that the failure of any Indemnified Person to so notify the Indemnifying Party
shall not relieve the Indemnifying Party of its obligations hereunder except to the extent that the
Indemnifying Party is actually and materially prejudiced by such failure to notify. In any
such proceeding, any Indemnified Person shall have the right to retain its own counsel, but
the fees and

15

 

expenses of such counsel shall be at the expense of such Indemnified Person unless:
(i) the Indemnifying Party and the Indemnified Person shall have mutually agreed to the retention
of such counsel; or (ii) in the reasonable judgment of counsel to such Indemnified Person (x)
representation of both parties by the same counsel would be inappropriate due to actual or
potential differing interests between them or (y) if there are one or more defenses available to
such Indemnified Person that is/are not available to the Indemnifying Party. Without the prior
written consent of the Indemnified Person, which consent shall not be unreasonably withheld,
delayed or conditioned, the Indemnifying Party shall not effect any settlement of any pending or
threatened action, claim or proceeding with respect to any Indemnified Person, unless such
settlement includes an unconditional release of such Indemnified Person from all liability arising
out of such proceeding.

          (d) (i) If the indemnification provided for in this Section 2.6 from the Indemnifying
Party is unavailable to an Indemnified Person hereunder or is inadequate in respect of any Losses
for which indemnification is provided under this Section 2.6, then the Indemnifying Party,
in lieu of indemnifying such Indemnified Person, shall contribute to the amount paid or payable by
such Indemnified Person as a result of such Losses in such proportion as is appropriate to reflect
the relative fault of the Indemnifying Party, on the one hand, and Indemnified Person(s), on the
other hand, in connection with the actions that resulted in such Losses, as well as any other
relevant equitable considerations. The relative fault of such Indemnifying Party and Indemnified
Person shall be determined by reference to, among other things, whether any action in question,
including any untrue or alleged untrue statement of a material fact or omission or alleged omission
to state a material fact, has been made by, or relates to information supplied by, such
Indemnifying Party or Indemnified Persons, and the parties’ relative intent, knowledge, access to
information and opportunity to correct or prevent such action. The amount paid or payable by a
party as a result of the Losses referred to above shall be deemed to include, subject to the
limitations set forth in Sections 2.6(b) and 2.6(c), any legal or other fees or
expenses reasonably incurred by such party in connection with any investigation or proceeding.

               (ii) The parties hereto agree that it would not be just and equitable if contribution pursuant
to this Section 2.6(d) were determined by pro rata allocation or by any other method of
allocation that does not take account of the equitable considerations referred to in Section
2.6(d)(i). Notwithstanding any other provision of this Agreement, in no event shall any
Investor’s contribution obligation exceed the excess of (A) the dollar amount of the proceeds
received by the Investor upon the sale of the Registrable Securities giving rise to such
contribution obligation over (B) the dollar amount of any damages that such Investor has otherwise
been required to pay by reason of the untrue or alleged untrue statement or omission or alleged
omission giving rise to such obligation. No Person guilty of fraudulent misrepresentation (within
the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any
Person who was not guilty of such fraudulent misrepresentation.

               (iii) If indemnification is available under this Section 2.6, the Indemnifying Parties
shall indemnify each Indemnified Person to the fullest extent provided in Section 2.6(a)
and Section 2.6(b) without regard to the relative fault of said Indemnifying Party or
Indemnified Person or any other equitable consideration provided for in this Section
2.6(d).

               (iv) If any provision of an indemnification or contribution clause in an underwriting
agreement or agency agreement executed by or on behalf of the Investor differs from a provision in
this Section 2.6, such provision in the underwriting agreement shall determine the
Investor’s rights in respect thereof; provided, however, that the terms set forth in any such
underwriting with respect to the Investor’s indemnification obligations shall be subject to the
restrictions on such obligations set forth in this Agreement.

16

 

          (e) Notwithstanding anything in this Agreement to the contrary, the indemnities and
obligations provided in this Section 2.6 shall survive the transfer of any Registrable
Securities by the Investor.

     2.7 Reporting. With a view to making available the benefits of certain rules and
regulations of the Commission which may at any time permit the sale of the Registrable Securities
to the public without registration, so long as the Company is subject to the reporting requirements
of the Exchange Act, the Company shall:

          (a) make and keep public information available, as contemplated in Rule 144(c) under the
Securities Act (or any successor rule);

          (b) use its best efforts to file with the Commission in a timely manner all reports and other
documents required of the Company under the Securities Act and the Exchange Act to, among other
things, remain eligible to use Form S-3 (or any successor thereto); and

          (c) so long as an Investor owns any Registrable Securities, furnish to such Investor, upon
request, (i) a written statement by the Company as to its compliance with the reporting
requirements of Rule 144 (or any successor rule), and of the Securities Act and the Exchange Act,
(ii) a copy of the most recent annual or quarterly report of the Company and such other reports and
documents so filed by the Company if such reports are not otherwise available on the EDGAR system;
and (iii) such other information as may be reasonably requested to permit the Investors to sell
such securities pursuant to Rule 144 without registration.

     2.8 Furnishing Information.

               (a) The Company shall make available, during normal business hours, for inspection and review
by each of the Investors whose Registrable Securities are to be included in a Registration
Statement, and their respective advisors and representatives (who may or may not be Affiliated with
such Investor), and any underwriter participating in any disposition of Common Stock on behalf of
the such Investors pursuant to a Registration Statement or amendments or supplements thereto or any
blue sky, NASD or other filing, all financial and other records, all filings with the Commission,
and all other corporate documents and properties of the Company as may be reasonably necessary for
the purpose of such review, and cause the Company’s officers, directors and employees, within a
reasonable time period, to supply all such information reasonably requested by such Investors or
any such representative, advisor or underwriter in connection with such Registration Statement
(including, without limitation, in response to all questions and other inquiries reasonably made or
submitted by any of them), prior to the filing and effectiveness of the Registration Statement for
the sole purpose of enabling such Investors and such representatives, advisors and underwriters and
their respective accountants and attorneys to conduct initial due diligence with respect to the
Company and the accuracy of such Registration Statement. Notwithstanding the foregoing, the
Company shall not disclose material nonpublic information to the Investors, or to advisors to or
representatives of the Investors, unless prior to disclosure of such information the Company
identifies such information as being material nonpublic information and provides the Investors,
such advisors and representatives with the opportunity to accept or refuse to accept such material
nonpublic information for review.

               (b) It shall be a condition precedent to the obligations of the Company to take any action
pursuant to this Article II that each Preferred Holder, Note Holder or Bond Warrant Holder, as the
case may be, furnish to the Company in writing such information regarding such Preferred Holder,

17

 

Note Holder or Bond Warrant Holder, as the case may be, the Registrable Securities held by it
and the intended method of disposition of such securities as shall be required to effect the
registration thereof.

     2.9 Additional Registration Rights. As of the date hereof, neither the Company nor
any of its security holders (other than as set forth on Schedule 2.9 attached hereto) has any right
to include securities of the Company in a Registration Statement other than the Registrable
Securities, and the Company shall not, after the date hereof, enter into any agreement providing
any rights to be included with a Registration Statement to any of its security holders or potential
security holders, without the prior written consent of the Requisite Series C Holders, the
Requisite Note Holders and the Requisite Bond Warrant Holders. Until after the effective date of a
Registration Statement which includes Registrable Securities owned by Series C Holders, Note
Holders and Bond Warrant Holders, the Company shall not file any other Registration Statement
solely with respect to shares to be offered by the Company or any Series AB Holder, including,
without limitation, a Registration Statement on Form S-1, S-3, S-4 or S-8 or any successor form to
any of the foregoing, without the consent of the Requisite Series C Holders, the Requisite Note
Holders and the Requisite Bond Warrant Holders.

     2.10 Lock Up. Each Series AB Holder shall, in connection with any registration of the
Company’s securities, upon the request of the Company or the underwriters managing any underwritten
offering of the Company’s securities, agree in writing not to effect any sale, transfer,
disposition or distribution of any of its Registrable Securities (other than that included in such
registration) without the prior written consent of the Company or such underwriters, as the case
may be, for such period of time not to exceed one hundred eighty (180) days from the effective date
of such registration as the Company or the underwriters may specify.

Article III Miscellaneous.

     3.1 Successors and Assigns. This Agreement may not be assigned by a party hereto
without the prior written consent of the Company and, with regards to the Common Stock issued upon
the conversion of the Notes or Series C Preferred Stock, Cerberus, and, with regard to the Common
Stock issued or issuable upon exercise of the Bond Warrants, Highland, and, if such assignment
materially adversely affects the Series AB Holders, the Requisite Series AB Holders;
provided, however, that a Preferred Holder, a Note Holder or a Bond Warrant Holder
may assign its rights and delegate its duties hereunder in whole or in part, without the prior
written consent of any other party, to an Affiliate and to any Person to whom such Preferred
Holder, Note Holder or Bond Warrant Holder, as the case may be, transfers any of the Registrable
Securities, or in the case of a Bond Warrant Holder, a Bond Warrant, provided, that, no such
assignment shall be effective or confer any right on any such assignee unless, prior to such
assignment, the assignee agrees in writing that such assignee will be bound by all provisions
binding on such Preferred Holder, Note Holder or Bond Warrant Holder, as the case may be. The
provisions of this Agreement shall inure to the benefit of and be binding upon the respective
permitted successors and assigns of the parties. Except for any other provisions of this Agreement
expressly to the contrary, nothing in this Agreement, express or implied, is intended to confer
upon any party other than the parties hereto or their respective successors and assigns any rights,
remedies, obligations, or liabilities under or by reason of this Agreement.

     3.2 Counterparts; Faxes. This Agreement may be executed in two or more counterparts,
each of which shall be deemed an original, but all of which together shall constitute one and the
same instrument. This Agreement may also be executed via facsimile, which shall be deemed an
original.

     3.3 Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement.

18

 

     3.4 Notices. Unless otherwise provided, any notice required or permitted under this
Agreement shall be given in writing and shall be deemed effectively given as hereinafter described:
(i) if given by personal delivery, then such notice shall be deemed given upon such delivery; (ii)
if given by fax, then such notice shall be deemed given upon receipt of confirmation of complete
transmittal with a confirming copy to be sent by email or first class mail; (iii) if given by mail,
then such notice shall be deemed given upon the earlier of (A) receipt of such notice by the
recipient or (B) three (3) days after such notice is deposited in first class mail, postage
prepaid; and (iv) if given by an internationally recognized overnight air courier, then such notice
shall be deemed given one (1) Business Day after delivery to such carrier. All notices shall be
addressed to the party to be notified at the address as follows, or at such other address as such
party may designate by ten (10) days’ advance written notice to the other party:

If to the Company:

Molecular Insight Pharmaceuticals, Inc.

160 Second Street

Cambridge, Massachusetts 02142

Attn: David Barlow

Fax: (617) 492-5664

With a copy to:

Foley & Lardner LLP

111 Huntington Avenue

26th Floor

Boston, Massachusetts 02199

Attn: Gabor Garai, Esq.

Fax: (617) 342-4001

If to any of the Investors:

to the addresses set forth on the signature pages attached hereto.

If to any Series AB Holder:

to the addresses set forth on Schedule A attached hereto.

or to such other address as any party hereto shall notify the other parties hereto (as provided
above) from time to time.

     3.5 Expenses. In the event that legal proceedings are commenced by any party to this
Agreement against another party to this Agreement in connection with this Agreement, the party or
parties which do not prevail in such proceedings shall severally, but not jointly, pay their pro
rata share of the reasonable attorneys’ fees and other reasonable out-of-pocket costs and expenses
incurred by the prevailing party in such proceedings.

     3.6 Amendments and Waivers. This Agreement shall not be amended without the prior
written consent of (i) the Requisite Series C Holders, the Requisite Note Holders and the Requisite
Bond Warrant Holders and (ii) if such amendment materially adversely affects the Series AB Holders,
the Requisite Series AB Holders. The Company may take any action herein prohibited, or omit to
perform any act herein required to be performed by it, only if the Company shall have obtained the
written consent

19

 

to such amendment, action or omission to act, of (i) the Requisite Series C Holders, the
Requisite Note Holders and the Requisite Bond Warrant Holders and (ii) if such amendment, action or
omission to act materially adversely affects the Series AB Holders, the Requisite Series AB
Holders.

     3.7 Publicity. No public release or announcement concerning the transactions
contemplated by this Agreement shall be issued by the Company, any of the Preferred Holders, Note
Holders or Bond Warrant Holders without, in the case of a release or announcement by any of the
Preferred Holders, the Note Holders or the Bond Warrant Holders, the prior written consent of the
Company, and, in the case of a release or announcement by the Company, prior written consent of the
Requisite Series C Holders, the Requisite Note Holders and the Requisite Bond Warrant Holders,
which in each case, shall not be unreasonably withheld; provided, however, in the case of any
release or announcement that may be required by law, such release or announcement may be made
without prior consent, but the Company or the Requisite Series C Holders or the Requisite Note
Holders or the Requisite Bond Warrant Holders, as the case may be, shall allow the other, to the
extent reasonably practicable in the circumstances, reasonable time to comment on such release or
announcement in advance of its dissemination.

     3.8 Severability. Any provision of this Agreement that is prohibited or unenforceable
in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such
prohibition or unenforceability without invalidating the remaining provisions hereof but shall be
interpreted as if it were written so as to be enforceable to the maximum extent permitted by
applicable law, and any such prohibition or unenforceability in any jurisdiction shall not
invalidate or render unenforceable such provision in any other jurisdiction. To the extent
permitted by applicable law, the parties hereby waive any provision of law which renders any
provision hereof prohibited or unenforceable in any respect.

     3.9 Entire Agreement. This Agreement, including Schedules, constitutes the entire
agreement among the parties hereof with respect to the subject matter hereof and thereof and
supersede all prior agreements and understandings, both oral and written, between the parties with
respect to the subject matter hereof and thereof.

     3.10 Further Assurances. The parties shall execute and deliver all such further
instruments and documents and take all such other actions as may reasonably be required to carry
out the transactions contemplated hereby and to evidence the fulfillment of the agreements herein
contained.

     3.11 Governing Law; Consent to Jurisdiction. This Agreement shall be governed by, and
construed in accordance with, the internal laws of the State of New York without regard to the
choice of law principles thereof (other than Section 5-1401 and Section 5-1402 of the New York
General Obligations Law). Each of the parties hereto irrevocably submits to the jurisdiction of
the courts of the State of New York located in New York County and the United States District Court
for the Southern District of New York for the purpose of any suit, action, proceeding or judgment
relating to or arising out of this Agreement and the transactions contemplated hereby. Service of
process in connection with any such suit, action or proceeding may be served on each party hereto
anywhere in the world by the same methods as are specified for the giving of notices under this
Agreement. Each of the parties hereto irrevocably consents to the jurisdiction of any such court
in any such suit, action or proceeding and to the laying of venue in such court. Each party hereto
irrevocably waives any objection to the laying of venue of any such suit, action or proceeding
brought in such courts and irrevocably waives any claim that any such suit, action or proceeding
brought in any such court has been brought in an inconvenient forum. THE COMPANY AND EACH OF THE
INVESTORS, SERIES A HOLDERS AND SERIES B HOLDERS HEREBY IRREVOCABLY WAIVES ANY AND ALL RIGHT TO
TRIAL BY JURY
IN ANY LEGAL PROCEEDING RELATING TO OR ARISING OUT OF THIS AGREEMENT

20

 

OR ANY OTHER TRANSACTION
DOCUMENT AND THE TRANSACTIONS CONTEMPLATED HEREBY AND THEREBY.

     3.12 Independent Nature of Investors’ Obligations and Rights. Except as expressly
provided herein and therein, the obligations of each Investor under this Agreement are several and
not joint with the obligations of any other Investor, and no Investor shall be responsible in any
way for the performance of the obligations of any other Investor under this Agreement. Nothing
contained herein, and no action taken by any Investor (including, without limitation, any of the
Co-Lead Investors) pursuant hereto or thereto, shall be deemed to constitute the Investors as a
partnership, an association, a joint venture or any other kind of entity, or create a presumption
that the Investors are in any way acting in concert or as a group with respect to such obligations
or the transactions contemplated by this Agreement. Each Investor acknowledges that no other
Investor (including, without limitation, any of the Co-Lead Investors) has acted as agent for such
Investor in connection with this Agreement or in making its investment in the Company and that no
Investor (including, without limitation, any of the Co-Lead Investors) will be acting as agent of
such Investor in connection with monitoring its investment in the Company or enforcing its rights
under this Agreement. Each Investor shall be entitled to independently protect and enforce its
rights, including, without limitation, the rights arising out of this Agreement, and it shall not
be necessary for any other Investor to be joined as an additional party in any proceeding for such
purpose. Notwithstanding anything contained in this Agreement to the contrary, neither of the
Co-Lead Investors shall have any duty, fiduciary or otherwise, to any other Investor by virtue of
such Investor serving as a Co-Lead Investor or otherwise.

     3.13 Injunctive Relief. It is acknowledged that it will be impossible to measure the
damages that would be suffered by an Investor if the Company fails to comply with the provisions of
this Agreement and that in the event of any such failure, the Investor will not have an adequate
remedy at law. The Investor shall, therefore, be entitled to obtain specific performance of any of
the Company’s obligations hereunder and to obtain immediate injunctive relief. The Company shall
not argue, as a defense to any proceeding for such specific performance or injunctive relief, that
the Investor has an adequate remedy at law.

[Remainder of Page Intentionally Left Blank]

21

 

[Company Signature Page]

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement or caused this Agreement
to be executed by their duly authorized representatives, as of the date first written above.

	 	 	 	 	 
	 	THE COMPANY:

MOLECULAR INSIGHT PHARMACEUTICALS, INC.

 	 
	 	By:  	/s/ John E. McCray
 	 
	 	 	Name:  	John E. McCray 	 
	 	 	Title:  	COO 	 

22

 

[Series A Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES A HOLDER:

James W. [illegible] Revocable Trust

 	 
	 	By:  	/s/ James W. [illegible]
 	 
	 	 	Name:  	James W. [illegible] 	 
	 	 	Title:  	Trustee 	 
	 
	 	 	 	 
	 
	Address:  	 	3100 Springhead Court	 
	 
	 	 	Narcoossee, FL 34771	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

23

 

[Series A Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES A HOLDER:

Patricia T. [illegible] Revocable Trust

 	 
	 	By:  	/s/ Patricia T. [illegible] 	 
	 	 	Name:  	Patricia T. [illegible] 	 
	 	 	Title:  	Trustee 	 
	 
	 	 	 	 
	 
	Address: 	3100 Springhead Court	 
	 
	 	 	Narcoossee, FL 34771	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

24

 

[Series A Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES A HOLDER:

 	 
	 	By:  	/s/ [illegible] 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 
	 	 	 	 
	 
	Address:  	 
	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

25

 

[Series A Holder Signature Page]

     IN WITNESS
WHEREOF, the undersigned has executed this Agreement as of the date first above written.

	 	 	 	 	 
	 	NAME OF SERIES A HOLDER:

 	 
	 	By:  	/s/ [illegible] M. Barber 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 
	 	 	 	 
	 
	Address: 	44 [Illegible]	 
	 
	 	 	Wellesley, MA [illegible]	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

26

 

[Series A Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES A HOLDER:

Meythaler Investment Partners, LC

 	 
	 	By:  	/s/ L. Charles Meythaler 	 
	 	 	Name:  	L. Charles Meythaler 	 
	 	 	Title:  	Managing Shareholder 	 
	 
	 	 	 	 
	 
	Address:  	399 Wahackme Road	 
	 
	 	 	New Canaan, CT 06840	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

27

 

[Series A Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES A HOLDER:

Meythaler Investors, LLC

 	 
	 	By:  	/s/ L. Charles Meythaler 	 
	 	 	Name:  	L. Charles Meythaler 	 
	 	 	Title:  	Manager 	 
	 
	 	 	 	 
	 
	Address:  	399 Wahackme Road	 
	 
	 	 	New Canaan, CT 06840	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

28

 

[Series B Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES B HOLDER:

CERBERUS PARTNERS, L.P.

 	 
	 	By:  	Cerberus Associates, LLC 	 
	 	 	Its General Partner 	 
	 
	 	 	 	 
	 	By:  	/s/ Jeffrey L. Lemasky 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 
	 	 	 	 
	 
	Address:  	299 Park Avenue	 
	 
	 	 	New York, NY	 
	 
	 	 	10171	 	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

29

 

[Series B Holder Signature Page]

     IN WITNESS
WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES B HOLDER:

CERBERUS AMERICA SERIES TWO HOLDINGS, LLC

 	 
	 	By:  	Cerberus Institutional Partners (America), L.P. — Series Two Its Managing Member 	 
	 
	 	 	 	 
	 	 	 
	 	By:  	Cerberus Institutional Associates (America), L.L.C. Its General Partner 	 
	 
	 	 	 	 
	 	 	 
	 	By:  	/s/ Jeffrey L. Lemasky 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 
	 	 	 	 
	 
	Address:  	299 Park Avenue	 
	 
	 	 	New York, NY	 
	 
	 	 	10171	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

30

 

[Series B Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES B HOLDER:

CERBERUS SERIES THREE HOLDINGS, LLC.

 	 
	 	By:  	Cerberus Institutional Partners, L.P. — Series Three	 
	 	 	Its Managing Member 	 
	 	 	 
	 	By:  	Cerberus Institutional 	 
	 	 	Associates, L.L.C 	 
	 	 	 
	 	By:  	/s/ Jeffrey L. Lemasky 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 
	 	 	 	 
	 
	Address: 	299 Park Avenue	 
	 
	 	 	New York, NY	 
	 
	 	 	10171	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

31

 

[Series B Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES B HOLDER:

Meythaler Investors, LLC

 	 
	 	By:  	/s/ L. Charles Meythaler 	 
	 	 	Name:  	L. Charles Meythaler 	 
	 	 	Title:  	Manager 	 
	 
	 	 	 	 
	 
	Address: 	399 Wahackme Road	 
	 
	 	 	New Canaan, CT 06840	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

32

 

[Series B Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES B HOLDER:

Meythaler Investment Partners, LC

 	 
	 	By:  	/s/ L. Charles Meythaler 	 
	 	 	Name:  	L. Charles Meythaley 	 
	 	 	Title:  	Managing Shareholder 	 
	 
	 	 	 	 
	 
	Address: 	399 Wahackme Road	 
	 
	 	 	New Canaan, CT 06840	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

33

 

[Series B Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES B HOLDER:

Daniel R. Frank

 	 
	 	By:  	/s/ Daniel Frank 	 
	 	 	Name:  	Daniel Frank 	 
	 	 	Title:  	 	 
	 
	 	 	 	 
	 
	Address: 	19 [illegible] Road	 
	 
	 	 	Darien, CT 06720	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

34

 

[Series C Holder Signature Page]

     IN WITNESS
WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

Patricia T. [ineligible] Revocable Trust

 	 
	 	By:  	/s/ Patricia T. [ineligible] 	 
	 	 	Name:  	Patricia T. [ineligible] 	 
	 	 	Title:  	Trustee 	 
	 
	 	 	 	 
	 
	Address:	3100 Springhead Court	 
	 
	 	 	Narcoossee, FL 34771	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

35

 

[Series C Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

James W. [ineligible] Revocable Trust

 	 
	 	By:  	/s/ James W. [ineligible] 	 
	 	 	Name:  	James W. [ineligible] 	 
	 	 	Title:  	Trustee 	 
	 
	 	 	 	 
	 
	Address:  	3100 Springhead Court	 
	 
	 	 	Narcoossee, FL 34771	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

36

 

[Series C Holder Signature Page]

     IN WITNESS
WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

MEYTHALER INVESTMENT PARTNERS LC

 	 
	 	By:  	/s/ L. Charles Meythaler 	 
	 	 	Name:  	L. Charles Meythaler 	 
	 	 	Title:  	Managing Shareholder 	 
	 
	 
	Address:  	399 Wahackme Road	 
	 
	 	 	New Canaan, CT 06840	 
	 
	 	 	 	 
	 
	 	 	 
	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 
	 
	 	 	 	 
	 
	 
	 

37

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:
 	 
	 	By:  	/s/ James T. Lenehan 	 
	 	 	Name:  	James T. Lenehan 	 
	 	 	Title:  	 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	1586 Hampton Road
	 	 
	 

	 	 	 	Rydal, PA 19046	 	 
	 

	 	 	 	215-896-3287	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 
	 
	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 

38

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

DANIEL R. FRANK

 	 
	 	By:  	/s/ Daniel Frank
 	 
	 	 	Name:  	Daniel R. Frank 	 
	 	 	Title:  	 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:

	 	
19 Whaling Road
	 	 
	 

	 	 	 	Darien, CT	 	 
	 

	 	 	 	06820	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):	 
	 
	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 

39

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

International Durham, Ltd.

 	 
	 	By:  	/s/ [ineligible]
 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

	 	 	 	 	 
	 
	 	Address:	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 
	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 

	 	 

40

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

American Durham, L.P.

 	 
	 	By:  	/s/ [ineligible]
 	 
	 	 	Title:  	 
	 	 	Name: 	 
	 

	 	 	 	 	 
	 
	 	Address:	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 
	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 

	 	 

41

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

CERBERUS SERIES THREE HOLDINGS, LLC.

 	 
	 	By:  	Cerberus Institutional Partners,
 	 
	 	 	L.P. -- Series Three
	 	 	Its Managing Member
	 
	 	By:  	Cerberus Institutional 	 
	 	 	Associates, L.L.C
	 	 	Its General Partner
	 
	 	By:  	/s/ Jeffrey L. Lemasky
 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	299 Park Avenue
	 	 
	 

	 	 	 	New York, NY	 	 
	 

	 	 	 	10171	 	 

	 	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 

42

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

CERBERUS AMERICA SERIES TWO HOLDINGS, LLC

 	 
	 	By:  	Cerberus Institutional Partners
 	 
	 	 	(America), L.P. -- Series Two
	 	 	Its Managing Member
	 
	 	By:  	Cerberus Institutional 	 
	 	 	Associates (America), L.L.C.
	 	 	Its General Partner
	 
	 	By:  	/s/ Jeffrey L. Lemasky 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	299 Park Avenue
	 	 
	 

	 	 	 	New York, NY	 	 
	 

	 	 	 	10171	 	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 

	 	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 

	 	 

43

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

CERBERUS PARTNERS, L.P.
 	 
	 	By:  	Cerberus Associates, L.L.C. 	 
	 	 	Its General Partner 	 
	 
	 	By:  	/s/ Jeffrey L. Lemasky 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 

	 	 	 	 	 
	 
	 	Address:	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):	 	 
	 
	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 
	 
	 	 	 	 
	 

	 	 	 

44

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

CERBERUS INTERNATIONAL, LTD.

BY: Partridge Hill Overseas

Management, LLC

Its Investment Manager

 	 
	 	By:  	/s/ Jeffrey L. Lemasky 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 
	 	 	 	 
	 
	Address: 	299 Park Avenue 	 
	 
	 	 	New York, NY	 
	 
	 	 	10171	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 
	 
	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 
	 	 

45

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

Institutional Benchmarks Series
(Master Feeder) Limited, acting solely
in respect of the Canopus series

 	 
	 	By:  	/s/ Didier Centis
 	 
	 	 	Name: Didier Centis	 	 
	 	 	Title: Authorized Signatory	 	 
	 

	 	 	 	 	 
	 

	Address:
	 	 
	 

	140 East
45th Street, 16th Floor	 	 
	 

	New York, NY 10017	 	 

	 	 	 	 	 
	 

	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 
	 	 	 	 
	 

	 	 
	 
	 	 	 	 
	 

	 	 

46

 

[Series C Holder Signature Page]

      IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 	NAME OF SERIES C HOLDER:

MedCap Partners L.P.

 	 
	 	By:  	/s/ [ineligible] Tumay
 	 
	 	 	Name: [ineligible] Tumay 	 
	 	 	Title:  	Managing Member of the GP 	 
	 
	 	 	 	 
	 
	Address:	500 3rd Street  #535	 
	 
	 	 	[ineligible], CA 94107	 
	 
	 	 	 	 
	 
	With a copy to (which shall not be deemed notice for purposes of the
Agreement):	 
	 
	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 
	 	 
	 
	 	 	 	 
	 
	 	 

47

 

[Series C Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first above
written.

	 	 	 	 	 
	 

	 	NAME OF SERIES C HOLDER:

Siemens Venture Capital GmbH	 	 
	 
	 	 	 	 
	 

	 	By:  /s/ Dr. Ralf Schnell
	 	/s/  Thomas Kolbinger
	 	 	 
	 

	 	Name:  Dr. Ralf Schnell
	 	Name:  Thomas Kolbinger
	 

	 	Title:  CEO
	 	Title:  CFO

	 	 	 	 	 	 	 
	 

	 	Address:
	 	Siemens Venture Capital GmbH
	 	 
	 

	 	 	 	Wittelsbacherplatz 2	 	 
	 

	 	 	 	80200 Munich	 	 
	 
	 	 	 	 	 	 
	 	 	With a copy to (which shall not be deemed notice for purposes of the Agreement):
	 
	 	 	 	 	 	 
	 	 	Andrew Jay	 	 
	 	 	Siemens Venture Capital, Inc.	 	 
	 	 	Boston MA 02116	 	 
	 	 	USA	 	 

48

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

International Durham, Ltd.

 	 
	 	By:  	/s/ [ineligible] 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

	 	 	 	 	 
	 

	 	Address:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 

	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

49

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

 American Durham, L.P.

 	 
	 	By:  	/s/ [ineligible]
 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

	 	 	 	 	 
	 

	 	Address:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 

	 	 	 	 

	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

50 

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

Bear Creek [ineligible] Ltd

 	 
	 	By:  	/s/ Andrew R. Midler 	 
	 	 	Name:  	Andrew R. Midler 	 
	 	 	Title:  	Director 	 
	 

	 	 	 	 	 
	 

	 	Address:
	 	Andrew R. Miller
	 

	 	 	 	6501 Red Rock Place
	 

	 	 	 	Suite 201
	 

	 	 	 	St. Thomas, USVI
	 

	 	 	 	00802  

	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

51 

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

JONATHAN GALLEN

 	 
	 	By:  	/s/ Jonathan Gallen 	 
	 	 	Name:  	Jonathan Gallen 	 
	 	 	Title:  	President, Ahab Capital
Management, Inc.
Investment Advisor, Ahab
International, Ltd. 	 
	 

Address:

Ahab International, Ltd.

299 Park Avenue

17th Floor

New York, NY

10171

	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

52 

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

JONATHAN GALLEN

 	 
	 	By:  	/s/ Jonathan Gallen 	 
	 	 	Name:  	Jonathan Gallen 	 
	 	 	Title:  	Managing Member, Pequod LLC,
Investment Advisor, Ahab Partners, L.P. 	 

Address:

Ahab Partners, L.P.

299 Park Avenue

17th Floor

New York, NY

10171

	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

53

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

CERBERUS SERIES THREE HOLDINGS, LLC.

 	 
	 	By:  	Cerberus Institutional Partners,
 	 
	 	 	L.P. — Series Three 	 
	 	 	Its Managing Member 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	Cerberus Institutional 	 
	 	 	Associates, L.L.C 	 
	 	 	Its General Partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	/s/ Jeffrey L. Lemasky 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 

	 	 	 	 	 
	 

	 	Address:
	 	299 Park Avenue
	 

	 	 	 	New York, NY
	 

	 	 	 	10171  

	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

	 
	 	 
	 

	 	 

54

 

[Note Holder Signature Page]

     IN WITNESS
WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

CERBERUS AMERICA SERIES TWO HOLDINGS, LLC

 	 
	 	By:  	Cerberus Institutional Partners (America), L.P. — Series Two	 
	 	 	Its Managing Member 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	Cerberus Institutional Associates (America), L.L.C.
 	 
	 	 	Its General Partner 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Jeffrey L. Lemasky
 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	299 Park Avenue
	 	 
	 

	 	 	 	New York, NY
	 	 
	 

	 	 	 	10171	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 

55

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

CERBERUS PARTNERS, L.P.

 	 
	 	By:  	Cerberus Associates, L.L.C.
 	 
	 	 	Its General Partner 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                      /s/ Jeffrey L. Lemasky
 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	299 Park Avenue
	 	 
	 

	 	 	 	New York, NY
	 	 
	 

	 	 	 	10171	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 

56

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

CERBERUS INTERNATIONAL, LTD.

BY: Partridge Hill Overseas

Management, LLC

Its Investment Manager
 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Jeffrey L. Lemasky
 	 
	 	 	Name:  	Jeffrey L. Lemasky 	 
	 	 	Title:  	Senior Managing Director 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	299 Park Avenue
	 	 
	 

	 	 	 	New York, NY
	 	 
	 

	 	 	 	10171	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 

57

 

[Note Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement or caused this Agreement to be
executed by its duly authorized representative, as of the date first written above.

	 	 	 	 	 
	 	NAME OF NOTE HOLDER:

Institutional Benchmarks Series

(Master Feeder) Limited, acting solely

in respect of the Canopus series

 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Didier Centis
 	 
	 	 	Name:  	Didier Centis 	 
	 	 	Title:  	Authorized Signatory 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	140 East 45th Street,
	 	 
	 

	 	 	 	16th Floor	 	 
	 

	 	 	 	New York, NY 10017	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 

58

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

Morgan Stanley & Co. Incorporated

 	 
	 	By:  	/s/ Dan Allen
 	 
	 	 	Name:  	Dan Allen 	 
	 	 	Title:  	Authorized Signatory 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	1585 Broadway, 2nd Floor
	 	 
	 

	 	 	 	New York, NY 10036	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):

	 
	 

	 	Daniel Yarsky

1585 Broadway, 2nd Floor

New York, NY 10036

212-761-2989

212-507-0626 (fax)

	 
	 

	 	Gina Walsh

1585 Broadway, 10th Floor

New York, NY 10036

212-761-1036

212-507-0473 (fax)
	 	 

59

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

Highland Crusader Offshore Partners,

L.P.

 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	Highland Crusader Fund GP, L.P.,
 	 
	 	 	its general partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	 Highland Crusader GP, LLC, its
 	 
	 	 	general partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	Highland Capital Management, L.P.,
 	 
	 	 	its sole member 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	Strand Advisors, Inc., its general
 	 
	 	 	partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Ken McGovern
 	 
	 	 	Name:  	Ken McGovern, Treasurer 	 
	 	 	Strand Advisors, Inc., General
Partner of Highland Capital
management, L.P. 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	13455 Noel Road, Suite 800
	 	 
	 

	 	 	 	Dallas, TX 75240	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 

60

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

Highland Credit Strategies Master

Fund, L.P.

 	 
	 

	 	 	 	 	 
	 	By: Highland General Partner, L.P.,

its general partner

 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	Highland GP Holdings LLC, its 	 
	 	 	general partner 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     Highland Capital Management, L.P.,
 	 
	 	 	its sole member 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     Strand Advisors, Inc., its general
 	 
	 	 	partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Ken McGovern
 	 
	 	 	Name:  	Ken McGovern, Treasurer 	 
	 	 	Strand Advisors, Inc., General
Partner of Highland Capital
Management, L.P. 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	13455 Noel Road, Suite 800
	 	 
	 

	 	 	 	Dallas, TX 75240	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 

61

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

Highland Credit Opportunities CDO, L.P.

 	 
	 	 	 
	 	 	 
	 	 	 
	 

	 	 	 	 	 
	 	By:  	Highland Credit Opportunities CDO GP, L.P., its general partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	Highland GP Holdings LLC, its
 	 
	 	 	general partner 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	 Highland Credit Opportunities CDO 	 
	 	 	GP, LLC, its general partner 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     Highland Capital Management, L.P.,
 	 
	 	 	its sole member 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     Strand Advisors, Inc., its general
 	 
	 	 	partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Ken McGovern
 	 
	 	 	Name:  	Ken McGovern, Treasurer 	 
	 	 	Strand Advisors, Inc., General Partner of Highland Capital Management, L.P. 	 
	 

	 	 	 	 	 	 	 
	 
	 	Address:	 	13455 Noel Road, Suite 800	 	 
	 
	 	 	 	Dallas, TX 75240	 	 

	 	 	 	 	 
	 
	 	With a copy to (which shall not be
deemed notice for purposes of the Agreement):	 	 
	 
	 	 	 	 
	 
	 	 
	 	 
	 
	 	 	 	 
	 
	 	 
	 	 
	 
	 	 	 	 
	 
	 	 
	 	 

62

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

QVT Fund LP

 	 
	 	By:  	QVT Associates GP LLC, its general
 	 
	 	 	partner 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Tracy Fu
 	 
	 	 	Name:  	Tracy Fu 	 
	 	 	Its: Managing Member 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	c/o QVT Financial LP
	 	 
	 

	 	 	 	1177 Avenue of the American	 	 
	 

	 	 	 	New York, NY 10036	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 

	 	 	 	 	 
	 

	 	/s/ Arthur Chu
	 	 
	 

	 	 	 	 
	 

	 	By: Arthur Chu	 	 
	 

	 	 	 	 
	 

	 	Its: Authorized Signatory	 	 
	 

	 	 	 	 

63

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

Quintessence Fund LP

 	 
	 	By:  	QVT Associates GP LLC, its general
 	 
	 	 	partner 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Tracy Fu
 	 
	 	 	Name:  	Tracy Fu 	 
	 	 	Its: Managing Member 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	c/o QVT Financial LP
	 	 
	 

	 	 	 	1177 Avenue of the American	 	 
	 

	 	 	 	New York, NY 10036	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 

	 	 	 	 	 
	 

	 	/s/ Arthur Chu
	 	 
	 

	 	 	 	 
	 

	 	By: Arthur Chu	 	 
	 

	 	 	 	 
	 

	 	Its: Authorized Signatory	 	 
	 

	 	 	 	 

64 

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

Taconic Opportunity Fund LP

 	 
	 	By:  	Taconic Capital Advisors LP, as
 	 
	 	 	Investment Advisor 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Joshua Miller
 	 
	 	 	Name:  	Joshua Miller 	 
	 	 	Title:  	Principal 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	Taconic Opportunity Fund LP
	 	 
	 

	 	 	 	Att: Josh Miller	 	 
	 

	 	 	 	450 Park Anenue,	 	 
	 

	 	 	 	9th Floor	 	 
	 

	 	 	 	New York, NY 10022	 	 

65 

 

[Bond Warrant Holder Signature Page]

     IN WITNESS WHEREOF, the undersigned has executed this Agreement as of the date first written
above.

	 	 	 	 	 
	 	NAME OF BOND WARRANT HOLDER:

McDonnell Investment Loan Opportunity Ltd.

 	 
	 	By:  	McDonnell Investment Management,
 	 
	 	 	LLC, as Investment Manager 	 
	 

	 	 	 	 	 
	 	 	 
	 	By:  	                                                     /s/ Kathleen A. Zarn
 	 
	 	 	Name:  	Kathleen A. Zarn 	 
	 	 	Title:  	Vice President 	 
	 

	 	 	 	 	 	 	 
	 

	 	Address:
	 	McDonnell Investment Management
	 	 
	 

	 	 	 	Alternative Credit Strategies	 	 
	 

	 	 	 	1515 W. 22nd Street — 11th	 	 
	 

	 	 	 	Floor	 	 
	 

	 	 	 	Oak Brook, IL 60523	 	 

	 	 	 	 	 
	 

	 	With a copy to (which shall not be
deemed notice for purposes of the
Agreement):
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 
	 
	 	 	 	 
	 

	 	 
	 	 

66exv4w4

 

EXHIBIT
4.4

EXECUTION VERSION

 

PLEDGE AND SECURITY AGREEMENT

dated as of November 16, 2007

Among

THE ENTITIES LISTED ON

SCHEDULE A HERETO,

as Pledgors

and

THE BANK OF NEW YORK TRUST COMPANY, N.A.,

as Collateral Agent

 

 

 

Table of Contents

	 	 	 	 	 	 	 	 	 
	 	 	Page	 	 	 	 	 
	ARTICLE 1

	SECURITY INTEREST

	 
	 	 	 	 	 	 	 	 
	Section 1.01 Grant of Security Interest
	 	 	1	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 1.02 Validity and Priority of Security Interest
	 	 	1	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 1.03 Maintenance of Status of Security Interest, Collateral and Rights
	 	 	1	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 1.04 Evidence of Status of Security Interest
	 	 	2	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 1.05 Pledgors Remain Obligated; Collateral Agent and Other Secured
Parties Not Obligated
	 	 	2	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	ARTICLE 2

	DISPOSITION OF COLLATERAL PROCEEDS

	 
	 	 	 	 	 	 	 	 
	Section 2.01 Rights of Collateral Agent
	 	 	2	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 2.02 Default
	 	 	3	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 2.03 Interest on Collateral
	 	 	3	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	ARTICLE 3

	CERTAIN REPRESENTATIONS AND WARRANTIES

	 
	 	 	 	 	 	 	 	 
	Section 3.01 Accuracy of Security Agreement Questionnaire
	 	 	3	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 3.02 Required Taxes
	 	 	3	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 3.03 Intellectual Property
	 	 	3	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 3.04 Corporate Governance
	 	 	4	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	ARTICLE 4

	CERTAIN COVENANTS

	 
	 	 	 	 	 	 	 	 
	A. General
	 	 	4	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 4.01 Certain Matters Relating to Preservation of Status of Security Interest
	 	 	4	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 4.02 Ownership and Defense of Collateral
	 	 	5	 	 	 	 	 

i

 

	 	 	 	 	 
	 	 	Page
	Section 4.03 Security Questionnaire
	 	 	5	 
	 
	 	 	 	 
	Section 4.04 Requested Information
	 	 	5	 
	 
	 	 	 	 
	Section 4.05 Collection of Collateral Obligations
	 	 	6	 
	 
	 	 	 	 
	Section 4.06 New Pledgors
	 	 	6	 
	 
	 	 	 	 
	B. Receivables
	 	 	6	 
	 
	 	 	 	 
	Section 4.07 Modification of Terms
	 	 	6	 
	 
	 	 	 	 
	Section 4.08 Verification
	 	 	6	 
	 
	 	 	 	 
	Section 4.09 Information
	 	 	6	 
	 
	 	 	 	 
	C. General Intangibles
	 	 	7	 
	 
	 	 	 	 
	Section 4.10 Performance of Terms
	 	 	7	 
	 
	 	 	 	 
	Section 4.11 Modification of Terms
	 	 	9	 
	 
	 	 	 	 
	Section 4.12 No Dispositions of General Intangibles
	 	 	10	 
	 
	 	 	 	 
	Section 4.13 Verification
	 	 	10	 
	 
	 	 	 	 
	Section 4.14 Schedule of Certain General Intangibles
	 	 	10	 
	 
	 	 	 	 
	Section 4.15 Other Patents and Copyrights
	 	 	10	 
	 
	 	 	 	 
	D. Inventory
	 	 	10	 
	 
	 	 	 	 
	Section 4.16 Location of Inventory
	 	 	10	 
	 
	 	 	 	 
	E. Equipment and Other Goods
	 	 	11	 
	 
	 	 	 	 
	Section 4.17 Location of Equipment and Other Goods
	 	 	11	 
	 
	 	 	 	 
	Section 4.18 Evidence of Ownership of Equipment and Other Goods
	 	 	11	 
	 
	 	 	 	 
	F. Investment Property Collateral and Instruments
	 	 	11	 
	 
	 	 	 	 
	Section 4.19 Status of Securities; Instruments Collateral
	 	 	11	 
	 
	 	 	 	 
	Section 4.20 Certain Rights of Collateral Agent and Pledgors
	 	 	12	 
	 
	 	 	 	 
	Section 4.21 No Amendments, etc., of Investment Property; Instruments Collateral
	 	 	12	 
	 
	 	 	 	 
	Section 4.22 No Disposition of Investment Property Collateral; Instruments
	 	 	13	 

 ii

 

	 	 	 	 	 	 	 	 	 
	 	 	Page	 	 	 	 	 
	Section 4.23 No Consent to Liens
	 	 	13	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 4.24 Jurisdictions of Securities and Commodity Intermediaries
	 	 	13	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 4.25 Information
	 	 	13	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 4.26 Certain Agreements of Pledgors As Issuers and Holders of Equity Interests
	 	 	13	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	G. Materiality Qualifications
	 	 	14	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 4.27 Requirement of Material Adverse Effect
	 	 	14	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	ARTICLE 5

	EVENT OF DEFAULT

	 	 	 	 	 	 	 	 	 
	A. Proceeds
	 	 	14	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 5.01 Application of Proceeds
	 	 	14	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	B. Remedies
	 	 	15	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 5.02 General
	 	 	15	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 5.03 Collateral Proceeds
	 	 	16	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 5.04 Inventory; Equipment and Other Goods
	 	 	17	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 5.05 Intellectual Property
	 	 	18	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 5.06 Restricted Offering Dispositions

	 	 	18	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Section 5.07 Notice of Disposition of Collateral
	 	 	18	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	ARTICLE 6

	MISCELLANEOUS

	 	 	 	 	 
	Section 6.01 Expenses of Each Pledgor’s Agreements and Duties
	 	 	18	 
	 
	 	 	 	 
	Section 6.02 Collateral Agent’s Right to Perform on a Pledgor’s Behalf
	 	 	19	 
	 
	 	 	 	 
	Section 6.03 Collateral Agent’s Right to Use Agents and to Act in Name of the Pledgors
	 	 	19	 
	 
	 	 	 	 
	Section 6.04 No Interference, Compensation or Expense
	 	 	19	 
	 
	 	 	 	 
	Section 6.05 Limitation of Obligations with Respect to Collateral
	 	 	19	 

 iii

 

	 	 	 	 	 
	 
	 	Page
	Section 6.06 Rights of Collateral Agent under UCC and Applicable Law
	 	 	19	 
	 
	 	 	 	 
	Section 6.07 Waivers of Rights Inhibiting Enforcement
	 	 	19	 
	 
	 	 	 	 
	Section 6.08 Power of Attorney
	 	 	20	 
	 
	 	 	 	 
	Section 6.09 Nature of Pledgor’s Obligations
	 	 	21	 
	 
	 	 	 	 
	Section 6.10 No Release of Pledgors
	 	 	21	 
	 
	 	 	 	 
	Section 6.11 Certain Other Waivers
	 	 	22	 
	 
	 	 	 	 
	Section 6.12 Independent Credit Evaluation
	 	 	23	 
	 
	 	 	 	 
	Section 6.13 Limitation on Amount of Obligations Secured
	 	 	23	 
	 
	 	 	 	 
	Section 6.14 Continuance and Acceleration of Secured Obligations upon Certain Events
	 	 	23	 
	 
	 	 	 	 
	Section 6.15 Recovered Payments
	 	 	23	 
	 
	 	 	 	 
	Section 6.16 Evidence of Secured Obligations
	 	 	24	 
	 
	 	 	 	 
	Section 6.17 Binding Nature of Certain Adjudications
	 	 	24	 
	 
	 	 	 	 
	Section 6.18 Subordination of Rights Against the Borrower, Guarantors and
Other Collateral
	 	 	24	 
	 
	 	 	 	 
	Section 6.19 Termination of Security Interest
	 	 	24	 
	 
	 	 	 	 
	Section 6.20 Designation of Notice
	 	 	25	 
	 
	 	 	 	 
	Section 6.21 Extension of Payment Dates
	 	 	25	 
	 
	 	 	 	 
	Section 6.22 GOVERNING LAW
	 	 	25	 
	 
	 	 	 	 
	Section 6.23 LIMITATION OF LIABILITY
	 	 	25	 
	 
	 	 	 	 
	Section 6.24 Counterparts
	 	 	26	 
	 
	 	 	 	 
	Section 6.25 Entire Agreement
	 	 	26	 
	 
	 	 	 	 
	Section 6.26 Successors and Assigns
	 	 	26	 
	 
	 	 	 	 
	Section 6.27 Delivery of Opinions Authorized
	 	 	26	 
	 
	 	 	 	 
	Section 6.28 Rights of Collateral Agent
	 	 	26	 

 iv

 

	 	 	 	 	 	 	 
	 	 	 	 	Page
	ARTICLE 7

	INTERPRETATION

	 
	 	Section 7.01 Definitional Provisions	 	 	26	 
	 
	 	 	 	 	 	 
	 
	 	Section 7.02 Other Interpretative Provisions	 	 	35	 
	 
	 	 	 	 	 	 
	 
	 	Section 7.03 Representations and Warranties	 	 	35	 

	 	 	 
	Schedule A List of Pledgors

	Schedule 1.03

	 	Schedule of Required Action
	Schedule 3.02

	 	Schedule of Required Recording and Other Taxes and Recording, Filing and Other Fees and Charges
	Schedule 3.03

	 	Intellectual Property
	Schedule 4.19(a)

	 	Schedule of Initial Investment Property and Instruments Collateral
	Schedule 4.21

	 	Schedule of Restrictions
	Schedule 5.07

	 	Notice of Disposition of Collateral
	Schedule 7.01(b)-1

	 	Schedule of Bank Accounts
	Schedule 7.01(b)-2

	 	Schedule of Commercial Tort Claims
	Schedule 7.01(b)-3

	 	Schedule of Constituent Collateral
	Schedule 7.01(b)-4

	 	Schedule of Letters of Credit
	 
	 	 
	Exhibit A

	 	Form of Security Agreement Questionnaire
	Exhibit B

	 	Form of Security Agreement Joinder

 v

 

PLEDGE AND SECURITY AGREEMENT

Dated as of November 16, 2007

     In consideration of the purchase of the Bonds (as hereinafter defined) issued under the
Indenture by and among Molecular Insight Pharmaceuticals, Inc. and The Bank of New York Trust
Company, N.A., as Trustee, Molecular Insight Pharmaceuticals, Inc., a Massachusetts corporation and
each of the Subsidiary Guarantors party from time to time thereto (each a “Pledgor” and
collectively the “Pledgors”) hereby agree with The Bank of New York Trust Company, N.A., as
Collateral Agent, as follows (with certain terms used herein being defined in Article 7):

ARTICLE 1

SECURITY INTEREST

     Section 1.01 Grant of Security Interest. To secure the payment, observance and
performance of the Secured Obligations, each Pledgor hereby mortgages, pledges and assigns the
Collateral to the Collateral Agent, and grants to the Collateral Agent a continuing and, except as
expressly permitted by this Agreement or the Indenture, first priority security interest in, and a
continuing lien upon, the Collateral.

     Section 1.02 Validity and Priority of Security Interest. Each Pledgor agrees that (a)
the Security Interest shall at all times be valid, perfected and enforceable against such Pledgor
and all third parties, in accordance with the terms hereof, as security for the Secured
Obligations, and (b) the Collateral shall not, nor shall any financial asset that is the subject of
any security entitlement that is Investment Property Collateral, at any time be subject to any
Lien, other than a Permitted Lien, that is prior to, on a parity with or junior to such Security
Interest, except that, unless an Event of Default exists, this Section 1.02 shall not apply
to (i) (A) payments under Payment Rights and Ordinary Distributions that such Pledgor is entitled
to, and does, receive and retain, and (B) withdrawals from Bank Accounts that such Pledgor is
entitled to make, and makes, pursuant to Section 2.02 (but this Section shall apply to any
asset that would otherwise constitute Collateral acquired with such Collateral or its proceeds) and
(ii) Collateral disposed of in a disposition that is permitted under the Financing Documents (but
this Section shall apply to any asset that would otherwise constitute Collateral acquired with such
Collateral or its proceeds).

     Section 1.03 Maintenance of Status of Security Interest, Collateral and Rights.

          (a) Required Action. Each Pledgor shall take all action, including the actions
specified on Schedule 1.03, that may be necessary or desirable, or that may be required by
applicable
law (i) to maintain at all times the validity, perfection, enforceability and priority of the
Security Interest in the Collateral in conformity with the requirements of Section 1.02,
(ii) to protect and preserve the Collateral at all times and (iii) to protect and preserve, and to
enable the exercise or enforcement of, the rights of the Collateral Agent therein and hereunder and
under the other Collateral Documents at all times.

 

 

          (b) Authorized Action. The Collateral Agent is hereby authorized to file one or more
financing or continuation statements or amendments thereto without the signature of or in the name
of any Pledgor, including the filing of a financing statement describing the Collateral as “all
assets”, “all personal property of the Pledgor now owned or hereafter acquired” or “all assets now
owned or hereafter acquired by the Pledgor or in which Pledgor otherwise has rights” or words to
that effect and will provide copies of such filings within ten (10) Business Days of filing. A
carbon, photographic or other reproduction of this Agreement or of any financing statement filed in
connection with this Agreement shall be sufficient as a financing statement. The filing by the
Collateral Agent in good faith of a financing statement which inadvertently covers property that is
not Collateral shall nonetheless be deemed an authorized filing; provided however
that the Collateral Agent shall correct such filing within ten (10) Business Days after being
notified in writing of the error. Notwithstanding anything to the contrary herein, the Collateral
Agent shall have no responsibility for the preparing, recording, filing, re-recording, or re-filing
of any financing statement, continuation statement or other instrument in any public office.

     Section 1.04 Evidence of Status of Security Interest. Each Pledgor shall at its own
expense and from time to time, upon the reasonable request of the Collateral Agent, deliver to the
Collateral Agent such file search reports from the UCC and other filing and recording offices.

     Section 1.05 Pledgors Remain Obligated; Collateral Agent and Other Secured Parties Not
Obligated. The grant by each Pledgor to the Collateral Agent of the Security Interest shall
not (a) relieve such Pledgor of any Liability to any Person under or in respect of any of the
Collateral or (b) impose on the Collateral Agent or the other Secured Parties any such Liability or
any Liability for any act or omission on the part of such Pledgor relative thereto.

ARTICLE 2

DISPOSITION OF COLLATERAL PROCEEDS

     Section 2.01 Rights of Collateral Agent.

          Subject to each Pledgor’s rights under Section 2.02 and except in the case of proceeds
of Collateral as to which a different disposition is expressly provided for herein or in any other
Financing Document, the Collateral Agent shall be entitled to
receive and retain all proceeds of Collateral, including all Extraordinary Distributions.
Subject to its rights under Section 2.02, each Pledgor shall, should it receive any such
proceeds, hold all such proceeds in trust for the Collateral Agent, not commingle the same with
other property or funds of such Pledgor and, unless the Collateral Agent shall have otherwise
instructed such Pledgor, deliver the same or cause the same to be delivered in the exact form
received, together with any necessary endorsements, to the Collateral Agent or to such Person or
Persons as the Collateral Agent may designate. The Collateral Agent is hereby irrevocably
authorized, either in the name and on behalf of any Pledgor or in its own name, to endorse and
deposit, or cause to be deposited, for collection, present, draw upon or under, or otherwise take
action to realize upon, all Instruments, Chattel Paper, Securities, Letters of Credit and Documents
that are Collateral for the purpose of holding and disposing of the proceeds thereof in accordance
with the terms hereof.

2

 

     Section 2.02 Default. Except during an Event of Default, (a) each Pledgor shall be
entitled to (i) receive and retain, or have delivered to it upon request, all payments under
Payment Rights and Ordinary Distributions and (ii) make withdrawals from all Bank Accounts and
retain such withdrawals, and (b) all Instruments, Chattel Paper, Securities, Letters of Credit and
Documents that are Collateral and being held by or on behalf of the Collateral Agent shall be made
available to such Pledgor upon request for purposes of presentation, collection or renewal (any
such arrangement to be effected to the extent deemed appropriate by the Collateral Agent against a
trust receipt or like document). Each request under clause (a)(i) or clause (b) and each
withdrawal under clause (a)(ii) of the preceding sentence shall constitute a Representation and
Warranty by such Pledgor that no Event of Default is continuing. No delivery of any Collateral
pursuant to such clause (b) of the preceding sentence shall terminate the Security Interest therein
and each Pledgor shall, within 18 days of its receipt of any such Collateral, either return such
Collateral or its proceeds to the Collateral Agent or such other Person as the Collateral Agent may
designate or, should the Security Interest in any such proceeds not be perfectible by possession,
take such other action as may be required by Section 1.03(a) to continue the perfection of
the Security Interest therein. During an Event of Default, the Collateral Agent shall have with
respect to all Collateral held by or for its account all of the rights afforded it under
Article 5.

     Section 2.03 Interest on Collateral. No Collateral held by the Collateral Agent
(other than amounts held in Bank Accounts invested in Cash Equivalents) shall bear interest, except
to the extent specifically agreed to in writing by the Collateral Agent and, unless otherwise so
agreed, any such interest shall be Collateral.

ARTICLE 3

CERTAIN REPRESENTATIONS AND WARRANTIES 

     Each Pledgor represents and warrants as follows:

     Section 3.01 Accuracy of Security Agreement Questionnaire. The Security Agreement
Questionnaire related to such Pledgor is, as of the date hereof, complete and correct in all
material respects.

     Section 3.02 Required Taxes. Except for those specified on Schedule 3.02, no
recording or other taxes or recording, filing or other fees or charges are payable in connection
with, arise out of, or are in any way related to, the execution, delivery, performance, filing or
recordation of any of the Collateral Documents or the creation or perfection of the Security
Interest.

     Section 3.03 Intellectual Property. As of the date hereof, (a) Schedule 3.03
lists all Patents that are registered or are subject to an application for registration, Trademarks
which are registered or are subject to an application for registration, Copyrights which are
registered or are subject to an application for registration, and any Patent, Patent License,
Trademark, Trademark License, Copyright and Copyright License that is material to or necessary in
the operation of such Pledgor’s business (b) each of such Patents, Patent Licenses, Trademarks,
Trademark Licenses, Copyrights and Copyright Licenses listed on Schedule 3.03 is
subsisting, valid and

3

 

enforceable against third Persons, and (c) each Pledgor is the sole and
exclusive owner or joint owner as indicated of the entire right, title and interest in and to each
of such Patents, Trademarks and Copyrights or has rights thereto, subject to the Patent, Trademark
and Copyright Licenses listed on Schedule 3.03.

     Section 3.04 Corporate Governance. Each Pledgor is a corporation, validly existing
and in good standing under the laws of the jurisdiction of its incorporation and qualified to do
business in all other jurisdictions where the nature of its business requires it to so qualify
except where the absence of such qualification would not have a Material Adverse Effect. Each
Pledgor has the requisite corporate power, as the case may be, to execute and deliver the Financing
Documents to which it is a party and to perform its obligations under the same. The execution,
delivery and performance by each Pledgor of its respective obligations under the Financing
Documents to which such entity is a party have been duly authorized by all necessary corporate
action on the part of each respective Pledgor. Each Pledgor has duly executed and delivered each
Financing Document to which it is a party. The execution, delivery and performance by each Pledgor
of the Financing Documents to which it is a party do not violate or conflict with such Pledgor’s
certificate or articles of incorporation or bylaws. No authorization, approval, or other action
by, and no notice to, consent of, order of, or filing with, any governmental authority or
securities exchange is
required in connection with the execution, delivery or performance by each Pledgor of the
Financing Documents to which it is a party.

ARTICLE 4

CERTAIN COVENANTS 

     Subject, in the case of each Section referred to therein, to the materiality qualifications
contained in the provisions of Section 4.27:

     A. General.

     Section 4.01 Certain Matters Relating to Preservation of Status of Security Interest.
(a) Each Pledgor shall (i) remain a Person of the type specified in the Security Agreement
Questionnaire and (ii) will not dissolve or merge or consolidate with, or into, any Person, except
for, to the extent permitted under the Indenture, mergers after which the Security Interest
complies with the requirements of Section 1.02.

          (b) Change of Location, Organizational Number, Name, Identity, etc. Each Pledgor
shall not change its (i) Location, (ii) organizational identification number from that specified in
the Security Agreement Questionnaire (or, if no such number is specified, adopt any such number) or
(ii) name, identity or corporate structure or jurisdiction of incorporation, unless, in any case,
(A) the Collateral Agent shall have had not less than 20 nor more than 75 days prior written notice
thereof, and (B) thereafter (1) no Default exists, and (2) the Security Interest complies with the
requirements of Section 1.02.

          (c) Chief Executive Office. Each Pledgor which is not a registered company shall
maintain its chief executive office and, if different from its chief executive office, each office
where the books and records relating to any Receivables or General Intangibles are kept

4

 

only at,
and shall keep a copy of its books and records at or in transit to, (i) a location specified
therefor in the Security Agreement Questionnaire or (ii) any other location provided that
(A) the Collateral Agent has received not less than 20 days prior notice of such location, (B) such
location is within one of the 50 States of the United States or the District of Columbia and (C)
(1) the Security Interest, with respect to any Collateral at such location, or affected by the
situs of such location, conforms to the requirements of Section 1.02 and (2) the Collateral
Agent shall have received acknowledgment copies of financing statements and opinions of counsel.

          (d) Trade Names. Without giving 5 days’ prior notice to the Collateral Agent, each Pledgor shall not do
business under any name, trade name or trade style not listed on the Security Agreement
Questionnaire.

          (e) Other Financing Statements. Except with respect to Permitted Liens, each Pledgor
shall not file or suffer to be on file, or authorize or permit to be filed or to be on file, in any
jurisdiction, any financing statement or like instrument with respect to the Collateral in which
the Collateral Agent is not named as the sole secured party.

     Section 4.02 Ownership and Defense of Collateral. Each Pledgor shall at all times (a)
have Rights to each asset that is Collateral free from any right, title or interest of any third
Person and (b) defend the Collateral against the claims and demands of all third Persons, except
that this Section 4.02 shall not apply to (i) but for only so long as such Lien is a
Permitted Lien, the interest in the Collateral and the claims and demands of a holder of a
Permitted Lien or (ii) Collateral to which Section 1.02 does not apply.

     Section 4.03 Security Questionnaire. Each Pledgor shall provide to the Collateral
Agent a completed Security Questionnaire, duly executed by an Authorized Officer of such Pledgor,
together with all schedules required to be delivered in connection therewith (a) on the date hereof
as required pursuant to the Financing Documents, (b) on each date required pursuant to Section
4.03 of the Indenture, and (c) on the date that any additional Pledgor becomes a party to this
Agreement pursuant to Section 4.06. In addition, if any information contained in any
Security Questionnaire previously delivered to the Collateral Agent shall become untrue or
incorrect in any material respect, or if any Pledgor acquires or disposes of any of the Collateral
such that any previously delivered Security Questionnaire is no longer accurate or complete in all
material respects, then within ten Business Days after such information becoming untrue, incorrect,
inaccurate or incomplete, such Pledgor shall execute and deliver a new Security Questionnaire to
the Collateral Agent, provided that the delivery of such new Security Questionnaire shall not serve
to cure, or constitute a waiver of, any Default or Event of Default that may have occurred as a
result of such information becoming untrue, incorrect, inaccurate or incomplete.

     Section 4.04 Requested Information. In addition to such other information as shall be
specifically provided for herein, each Pledgor shall furnish to the Collateral Agent such other
information with respect to the Collateral as the Collateral Agent or any Secured Party may
reasonably request from time to time, in each case in form and substance and certified in a manner
satisfactory to the Person requesting such information.

5

 

     Section 4.05 Collection of Collateral Obligations. Subject to the rights of the Collateral Agent hereunder, each Pledgor shall endeavor to
collect from the Collateral Debtor of each Collateral Obligation, when due, all amounts owing
thereunder, except that, unless an Event of Default shall exist, this Section 4.05 shall
not require such Pledgor to take any action not in accordance with sound business judgment and its
customary collection practices as in effect from time to time.

     Section 4.06 New Pledgors. Pursuant to Section 4.31 of the Indenture, if a
Pledgor shall at any time form or acquire any new Subsidiary which is not a Pledgor hereunder, such
Pledgor shall (i) promptly deliver to the Collateral Agent a supplement to this Agreement,
substantially in the form of Exhibit B to this Agreement, duly completed and executed and
(ii) promptly cause such Subsidiary to complete and deliver a Security Agreement Questionnaire
substantially in the form of Exhibit A to this Agreement.

     B. Receivables.

     Section 4.07 Modification of Terms.

          (a) Each Pledgor shall not enter into any agreement providing for any deduction from any
Receivable except for agreements that are made in the ordinary course of business.

          (b) Each Pledgor shall not rescind or cancel any obligation evidenced by any Receivable or
modify any term thereof or make any adjustment with respect thereto, or extend or renew the same,
or compromise or settle any dispute, claim, suit or legal proceeding relating thereto, without the
prior written consent of the Collateral Agent, except that, unless an Event of Default shall exist,
such Pledgor may, with respect to any Receivable, but only in the ordinary course of its business
and in accordance with sound business judgment and its customary collection practices as in effect
from time to time (i) extend the time of payment thereof, (ii) in the case of a Receivable, grant a
refund or credit with respect thereto for returned, damaged or non-complying merchandise and (iii)
settle the same for an amount less than the then unpaid balance thereof.

     Section 4.08 Verification. If an Event of Default exists, the Collateral Agent shall
have the right, in the name and on the stationery of any Pledgor or in such name as the Collateral
Agent may select, to verify the validity, amount or any other matter relating to any Receivable by
mail, telephone or any other means.

     Section 4.09 Information. 

          (a) Master Address List and Other Documents. Each Pledgor shall (i) each fiscal
quarter and, if a Default shall have occurred and is continuing, upon the request of the Collateral
Agent deliver to the Collateral Agent and each Secured Party a master address list and an open items statement of
each Collateral Debtor with respect to its Receivables and (ii) if a Default has occurred and is
continuing, deliver copies of invoices, proofs of delivery, repayment histories, present status
reports, and such other information relating to the Receivables and their status as the Collateral
Agent or any Secured Party may request.

6

 

          (b) Material Contracts. Each Pledgor shall at least annually and, if a Default shall
have occurred and is continuing, upon the request of the Collateral Agent (i) supply the Collateral
Agent with such information with respect to each Material Contract as the Collateral Agent may
reasonably request, (ii) give the Collateral Agent a list of each Material Contract entered into
after the date hereof, and (iii) deliver to the Collateral Agent complete and correct copies of
each Material Contract.

     C. General Intangibles.

     Section 4.10 Performance of Terms.

          (a) All General Intangibles Other than Intellectual Property. Each Pledgor shall duly
fulfill all obligations on its part to be fulfilled under or in connection with all General
Intangibles, other than Intellectual Property, and shall do nothing to impair the rights of the
Collateral Agent therein.

          (b) Patents.

          (i) Each Pledgor will not, and will not permit any licensee or sublicensee to, take
any action or omit to take any action whereby any Patent or Patent License may become
invalid, unenforceable or dedicated to the public.

          (ii) Each Pledgor will notify the Collateral Agent immediately in writing if it knows,
or has reason to know, (A) that any Patent or Patent License is or may become invalid or
unenforceable, and (B) of the institution of, or any determination or material development
in, any proceeding, wherever pending, affecting adversely any such Patent or Patent License
or its rights thereunder.

          (iii) Whenever a Pledgor, either by itself or through any agent, employee, licensee or
designee, shall file an application for a Patent with any Intellectual Property Recording
Office, such Pledgor shall report such filing in writing to the Collateral Agent within the
later of (1) five Business Days after the last day of the month in which such filing occurs
or (2) fifteen days after such filing, and it shall take all necessary and reasonable steps
to maintain and pursue each such application and maintain each issued Patent including
making timely filings of applications for renewal, affidavits of use, affidavits of
incontestability and payment of maintenance fees, and to initiate opposition, interference
and cancellation proceedings against third parties consistent with Pledgor’s sound business
judgment.

          (iv) Each Pledgor will take all action that such Pledgor determines is reasonable and
necessary to preserve and maintain its rights in, to and under all Patents and Patent
Licenses including continuing to mark any Product with the relevant patent number as
necessary and sufficient to establish and preserve its maximum rights under applicable
patent laws.

          (v) In the event that any Patent is infringed by a third party, each Pledgor shall
promptly notify the Collateral Agent in writing after it learns thereof and shall, unless
such Pledgor shall reasonably determine, and promptly notify the Collateral Agent

7

 

in
writing, that such Patent is no longer material to its business, promptly take such actions
as such Pledgor shall reasonably deem appropriate under the circumstances to protect such
Patent.

          (vi) Upon the occurrence and during the continuance of an Event of Default, each
Pledgor shall use its best efforts to obtain all requisite consents or approvals by the
licensor of each Patent License to effect the assignment of all of such Pledgor’s right,
title and interest thereunder to the Collateral Agent, for the ratable benefit of the Bond
holders.

          (c) Trademarks.

          (i) Each Pledgor (either itself or through licensees) will (A) use each Trademark on
each and every class of goods or services to which such Trademark is applicable so as to
maintain such Trademark in full force and free from any claim of abandonment or invalidity
for non-use, (B) maintain the quality of goods and services offered under such Trademark,
(C) employ such Trademark with the appropriate notice of registration (whether U.S. or
non-U.S. registration), (D) not adopt or use any mark which is confusingly similar to or a
colorable imitation of such Trademark, unless such mark is subject to the Security Interest
and the Security Interest with respect to such mark conforms to the requirements of
Section 1.02, and (E) not (and will not permit any licensee or sublicensee thereof
to) take any action or omit to take any action whereby any Trademark may become invalid.

          (ii) Each Pledgor will notify the Collateral Agent immediately in writing, if it
knows, or has reason to know, (A) that any application or registration relating to any
Trademark or Trademark License may be opposed or cancelled by a third party or become
abandoned, cancelled, expired or dedicated, and (B) of the institution of, or any
determination or material development in, any proceeding, wherever pending, affecting
adversely such Pledgor’s ownership of any Trademark or its right to register the same or to
keep and maintain the same.

          (iii) Whenever a Pledgor, either by itself or through any agent, employee, licensee or
designee, shall file an application for the registration of any Trademark with any
Intellectual Property Recording Office, such Pledgor shall report such filing in writing to
the Collateral Agent within the later of (1) five Business Days after the last day of the month in which such filing occurs or (2)
fifteen days after such filing.

          (iv) Each Pledgor will take all action that such Pledgor determines is reasonable and
necessary to preserve and maintain all rights in, to and under all Trademarks and Trademark
Licenses including continuing to mark any Product or any other written material with any
such notation as is necessary and sufficient to establish and preserve its maximum rights
under applicable trademark laws.

          (v) In the event that any Trademark is infringed, misappropriated or diluted by any
Person, or if any Pledgor has reason to believe that any Trademark is about to be
infringed, misappropriated or diluted by any Person, each Pledgor shall

8

 

promptly notify the
Collateral Agent in writing after it learns thereof and shall, unless such Pledgor shall
reasonably determine, and promptly notify the Collateral Agent in writing, that such
Trademark is no longer material to its business, promptly take such actions as such Pledgor
shall reasonably deem appropriate under the circumstances to protect such Trademark.

          (d) Copyrights.

          (i) Each Pledgor will not, and will not permit any licensee or sublicensee to, take
any action or omit to take any action whereby any Copyright may become invalidated or be
injected into the public domain.

          (ii) Each Pledgor shall notify the Collateral Agent immediately in writing if it
knows, or has reason to know, (A) that any Copyright or Copyright License has or may become
invalid or has been or may be injected into the public domain, and (B) of the institution
of, or any determination or material development in, any proceeding, wherever pending,
affecting such Pledgor’s ownership or the validity of any Copyright or Copyright License.

          (iii) Whenever a Pledgor, either by itself or through any agent, employee, licensee or
designee, shall file an application for the registration of any Copyright with any
Intellectual Property Recording Office, such Pledgor shall report such filing to the
Collateral Agent within the later of (1) five Business Days after the last day of the month
in which such filing occurs or (2) fifteen days after such filing.

          (iv) Each Pledgor will take all action such Pledgor determines is reasonable and
necessary to preserve and maintain all rights in, to and under all Copyrights and Copyright
Licenses.

          (v) In the event that any Copyright is infringed by any Person, or if any Pledgor has
reason to believe that any Copyright is about to be infringed, each Pledgor shall promptly
notify the Collateral Agent in writing after it learns thereof and shall, unless such
Pledgor shall reasonably determine, and promptly notify the Collateral Agent in writing,
that such Copyright is no longer material to
its business, promptly take such actions as such Pledgor shall reasonably deem
appropriate under the circumstances to protect such Copyright.

     Section 4.11 Modification of Terms. Each Pledgor shall not rescind or cancel any
obligation due to it evidenced by any General Intangible or modify any term thereof or make any
adjustment with respect thereto, or extend or renew the same, or compromise or settle any dispute,
claim, suit or legal proceeding relating thereto, without the prior written consent of the
Collateral Agent, except that, unless an Event of Default shall exist, such Pledgor may, with
respect to any General Intangible, but only in the ordinary course of its business and in
accordance with sound business judgment and its customary collection practices as in effect from
time to time (i) extend the time of payment thereof, (ii) settle the same for an amount less than
the then unpaid balance thereof and (iii) amend or otherwise modify the terms thereof.

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     Section 4.12 No Dispositions of General Intangibles. Each Pledgor shall not sell or
otherwise dispose of any General Intangible or any interest therein, or grant any license or
sublicense thereunder, except to the extent expressly permitted by the terms of the Indenture.

     Section 4.13 Verification. If an Event of Default exists, the Collateral Agent shall
have the right, in the name and on the stationery of any Pledgor or in such name as the Collateral
Agent may select, to verify the validity, amount or any other matter relating to any General
Intangible by mail, telephone or any other means.

     Section 4.14 Schedule of Certain General Intangibles. Each Pledgor shall deliver to
the Collateral Agent, (1) quarterly, and, after the occurrence and continuation of a Default, as
the Collateral Agent or any Secured Party may request from time to time, (a) a schedule showing, as
to each General Intangible that is a Collateral Obligation, (i) the name and address of the
Collateral Debtor, (ii) the nature of such Collateral Obligation, (iii) whether it is (A) fixed or
contingent or (B) liquidated or unliquidated and (iv) if liquidated, the amount thereof and (b) a
schedule showing the identity (in the case of patents, by patent number and issue date, in the case
of patent applications, by serial number and filing date, in the case of registered trademarks, by
registration number, registration date and description of goods and/or services covered, in the
case of trademark applications, by serial number, filing date and description of goods and/or
services covered, in the case of registered copyrights, by registration number, registration date,
title, and brief description of material covered, and in the case of copyright applications, date
of creation and first publication, title and brief description of material covered) of each patent,
patent application, trademark, trademark application, copyright and copyright application issued
to, applied for or pending by such Pledgor and not previously so identified to the Collateral Agent
in writing and (2) promptly after granting or acquiring the same, copies, not previously delivered
to the
Collateral Agent, of all licenses and sub-licenses relating to any of the foregoing for which
such Pledgor is a party thereto.

     Section 4.15 Other Patents and Copyrights. In accordance with Section 4.03,
within 15 days of the acquisition of any Patent which is registered or is subject to an application
for registration, any Trademark which is registered or is subject to an application for
registration, any Copyright which is registered or is subject to an application for registration,
and any Patent, Patent License, Trademark, Trademark License, Copyright and Copyright License that
is material to or necessary in the operation of such Pledgor’s business, the relevant Pledgor shall
deliver to the Collateral Agent an updated Security Agreement Questionnaire, together with a copy
of such Patent, Patent License, Trademark, Trademark License, Copyright and Copyright License, as
the case may be, with a grant of security as to such Patent, Patent License, Trademark, Trademark
License, Copyright and Copyright License, as the case may be, confirming the grant thereof
hereunder.

     D. Inventory.

     Section 4.16 Location of Inventory. Each Pledgor shall keep its Inventory only at, or
in transit to, (a) a location specified in the Security Agreement Questionnaire as a current
location for Inventory or (b) any other location provided that (i) the Security Interest in
Inventory at such location conforms to the requirements of Section 1.02, (ii) in the case
of any location where the Inventory is within the possession or control of any third Person, if
required by the Indenture,

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such Person shall have acknowledged and agreed with the Collateral
Agent, in a writing satisfactory in all respects thereto, that all Inventory at any time in its
possession or control is subject to the Security Interest and is to be held for the account of, and
is only to be released or transferred upon instructions of, the Collateral Agent, and (iii) in the
case of any Inventory located on premises leased to or mortgaged by a Pledgor, if required by the
Indenture, such Pledgor shall have delivered to the Collateral Agent a waiver from each applicable
lessor or mortgagee substantially in the form of Exhibit F to the Indenture or otherwise
reasonably acceptable to the Collateral Agent and received a waiver of any applicable
warehouseman’s lien (subject to the terms of Section 6.02(m) of the Indenture).

     E. Equipment and Other Goods.

     Section 4.17 Location of Equipment and Other Goods. Each Pledgor shall maintain its
Equipment and Other Goods only at, or in transit to, (a) a location specified in the Security
Agreement Questionnaire as a current location for Equipment and Other Goods or (b) any other
location provided that (i) the Security Interest in Equipment and Other Goods at such
location conforms to the requirements of Section 1.02, (ii) in the case of any location
where the Equipment and Other Goods is within the possession or control of any third Person, such
Person shall have acknowledged and agreed with the Collateral Agent, in a writing satisfactory in
all respects thereto, that all Equipment and Other Goods at any time in its possession or control
is subject to the Security Interest and is to be held for the benefit of, and is only to be
released or transferred upon instructions of, the Collateral Agent and (iii) in the case of any
Equipment and Other Goods located on premises leased to or mortgaged by a Pledgor, such Pledgor
shall have delivered to the Collateral Agent a waiver from each applicable lessor or mortgagee
substantially in the form of Exhibit F to the Indenture or otherwise reasonably acceptable
to the Collateral Agent and received a waiver of any applicable warehouseman’s lien (subject to the
terms of Section 6.02(m) of the Indenture).

     Section 4.18 Evidence of Ownership of Equipment and Other Goods. Each Pledgor shall,
upon request by the Collateral Agent or any Secured Party, deliver to the Collateral Agent and each
Secured Party evidence of ownership of any of the Inventory, Equipment and Other Goods, including
certificates of title, bills of sale and bills of lading.

     F. Investment Property Collateral and Instruments.

     Section 4.19 Status of Securities; Instruments Collateral. (a) Each Pledgor
represents and warrants that as of the date hereof that (a) the shares or other units of Equity
Interests, and the principal amounts of Indebtedness listed on Schedule 4.19(a) represent
the respective percentages of, in the case of such Equity Interests required to be pledged
hereunder, the outstanding shares or other units of such Equity Interests and, in the case of such
Indebtedness, the outstanding principal amounts of the Securities that are Indebtedness or
Instruments, that are set forth on such Schedule, and (b) it owns the Equity Interests,
Indebtedness which are securities and Instruments free and clear of all Liens and any agreements
which would affect the pledge of such Collateral or its sale or disposition.

     Each Pledgor shall, if such Pledgor has, as a result of its ownership of the Equity Interest,
become entitled to receive or shall receive any stock or other certificate

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(including, without limitation, any certificate representing a dividend or a distribution in
connection with any reclassification, increase or reduction of capital or any certificate issued in
connection with any reorganization), option or rights, whether in addition to, in substitution for,
as a conversion of, or in exchange for any shares or units of the Equity Interest, or otherwise in
respect thereof, accept the same as the Collateral Agent’s agent, hold the same in trust for the
Collateral Agent and deliver the same forthwith to the Collateral Agent in the exact form received,
duly indorsed by the Pledgor to the Collateral Agent, if required, together with an undated stock
power or limited liability company interest power covering such certificate duly executed in blank
and with, if the Collateral Agent so requests, signature guaranteed, to be held by the Collateral
Agent, subject to the terms hereof as additional collateral security for the Secured Obligations.
Any sums paid upon or in respect of the Equity Interest upon the liquidation or dissolution of a
Pledgor shall be paid over to the Collateral Agent as additional collateral security for the
Secured Obligations unless otherwise required under the Indenture, and in case any distribution of
capital shall be made on or in respect of the Equity Interest or any property shall be distributed
upon or with respect to the Equity Interest pursuant to the recapitalization or reclassification of
the capital of such Pledgor or pursuant to the reorganization thereof, unless otherwise required
under the Indenture, the property so distributed shall be delivered to the Collateral Agent,
subject to the terms hereof, as additional collateral security for the Secured Obligations. If any
sums of money or property so paid or distributed in respect of the Equity Interest shall be
received by such Pledgor, such Pledgor shall, until such money or property is paid or delivered to
the Collateral Agent and unless otherwise required under the Indenture, hold such money or property
in trust for the Collateral Agent segregated from other funds of the Pledgor, as additional
collateral security for the Secured Obligations.

     Section 4.20 Certain Rights of Collateral Agent and Pledgors. (a) At any time and
from time to time, the Collateral Agent may, and is hereby authorized to, transfer into or register
in its name or the name of its nominee any or all of the Securities and Instruments that are
Collateral. Each Pledgor shall promptly give the Collateral Agent and each Secured Party copies of
all notices and other communications received by such Pledgor with respect to any Securities and
Instruments that are Collateral registered in the name of such Pledgor.

          (b) During an Event of Default, the Collateral Agent, after a notice to a Pledgor that it
intends to exercise its rights under this Section 4.20(b), may, from time to time, in its
own or such Pledgor’s name, exercise any and all rights, powers and privileges with respect to the
Securities and Instruments that are Collateral, and with the same force and effect, as could such
Pledgor.

          (c) Unless and until the Collateral Agent exercises its rights under Section 4.20(b),
each Pledgor may, with respect to any of the Securities and Instruments that are Collateral, vote
and give consents, ratifications and waivers with respect thereto, except to the extent that any
such would be for a purpose that would constitute or result in a Default.

     Section 4.21 No Amendments, etc., of Investment Property; Instruments Collateral.
Subject to Section 4.20(c), each Pledgor shall not make or consent to any amendment or
other modification or waiver with respect to any Investment Property or Instruments that are
Collateral or enter into or permit to exist any restriction with respect to the transferability of
or any rights

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under or in respect of such Collateral other than restrictions arising under the
Financing Documents or set forth on Schedule 4.21.

     Section 4.22 No Disposition of Investment Property Collateral; Instruments. Except as
otherwise permitted under the Indenture, each Pledgor shall not, sell, lease, transfer or otherwise
dispose of any Instruments or Investment Property Collateral, including, if the Collateral includes
any securities accounts or commodity accounts, any financial asset or commodity contract carried
therein, or, if the Investment Property Collateral includes any security entitlements, any
financial asset subject thereto, or any interest therein, except that this Section shall not apply
to any Ordinary Distributions that such Pledgor is entitled to, and does, receive and retain
pursuant to Section 2.02.

     Section 4.23 No Consent to Liens. Each Pledgor shall not agree with any securities or
commodity intermediary that such intermediary, or suffer any agreement to exist pursuant to which
any such intermediary, may grant a Lien on any investment property or financial asset (a) that is
or is to be Collateral or (b) that is the subject of any security entitlement that is or is to be
Collateral.

     Section 4.24 Jurisdictions of Securities and Commodity Intermediaries. Each Pledgor
shall not, after the date hereof, enter into any Contract with any securities intermediary or with
any commodity intermediary with respect to any investment property or financial asset that is or is
to be Collateral, unless such Contract or another agreement specifies effectively with respect to
such Collateral that such securities intermediary’s or commodity intermediary’s Jurisdiction shall
be a Revised Article 8 State.

     Section 4.25 Information.

          (a) New Accounts. Each Pledgor shall give to the Collateral Agent not less than 15
days’ prior notice of the opening of each new securities account or commodity account that itself
will be Collateral, or to which in the case of a securities account, financial assets are to be
credited (or with respect to which there will be security entitlements), or in which, in the case
of a commodity account, commodity contracts are to be carried, that are or are to be Collateral,
specifying, as appropriate, the securities intermediary or the commodity intermediary maintaining
such account, the account number and the Jurisdiction of each such Person.

          (b) Change of Jurisdiction. Each Pledgor shall give to the Collateral Agent prompt
notice after such Pledgor learns of, but in any event within 60 days after such Pledgor learns of,
any change of the Jurisdiction of a securities intermediary or a commodity intermediary maintaining
a securities account or commodity account that itself is Collateral, or to which investment
property or financial assets are credited (or with respect to which there are security
entitlements), or in which commodity contracts are carried, that are Collateral, specifying such
new Jurisdiction.

     Section 4.26 Certain Agreements of Pledgors As Issuers and Holders of Equity Interests.

          (a) In the case of each Pledgor which is an issuer of Investment Property Collateral, such
Pledgor agrees to be bound by the terms of this Agreement relating to the

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Investment Property Collateral issued by it and will comply with such terms insofar as such terms are applicable to it.

          (b) In the case of each Pledgor which is a partner, shareholder or member, as the case may be,
in a partnership, limited liability company or other entity, such Pledgor hereby consents to the
extent required by the applicable Organizational Document to the pledge by each other Pledgor,
pursuant to the terms hereof, of the Securities in such partnership, limited liability company or
other entity and, upon the occurrence and during the continuance of an Event of Default, to the
transfer of such Securities to any Collateral Agent or its nominee and to the substitution of any
Collateral Agent or its nominee as a substituted partner, shareholder or member in such
partnership, limited liability company or other entity with all the rights, powers and duties of a
general partner, limited partner, shareholder or member, as the case may be.

     G. Materiality Qualifications.

     Section 4.27 Requirement of Material Adverse Effect. Unless an Event of Default shall
exist, Section 4.05, Section 4.07, Section 4.10, Section 4.11,
Section 4.12 and Section 4.19(a) shall not apply in any circumstances where
noncompliance, together with all other noncompliances with this Agreement will not have (a) a
Material Adverse Effect on the Company or its Subsidiaries or (b) a Product MAE on any Primary
Product.

ARTICLE 5

EVENT OF DEFAULT 

     During an Event of Default, and in each such case:

     A. Proceeds.

     Section 5.01 Application of Proceeds. All cash proceeds received by the Collateral
Agent upon any sale of, collection of, or other realization upon, all or any part of the Collateral
and all cash held by the Collateral Agent as Collateral shall, subject to the Collateral Agent’s
right to continue to hold the same as cash Collateral, be applied as follows:

     First: To the payment of all out-of-pocket costs and expenses incurred by the
Collateral Agent or any other Secured Party in connection with the sale of or other
realization upon Collateral, including attorneys’ fees and disbursements;

     Second: To the payment of the Secured Obligations owing to the Collateral
Agent in such order as the Collateral Agent may elect (with the Pledgors remaining liable
for any deficiency);

     Third: To the payment of the other Secured Obligations in such order as
required by the terms of the Indenture (with the Pledgors remaining liable for any
deficiency); and

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     Fourth: To the extent of the balance (if any) of such proceeds, to the payment
to the Pledgors, subject to applicable Law and to any duty to pay such balance to the holder
of any subordinate Lien in the Collateral.

     B. Remedies.

     Section 5.02 General.

          (a) Collateral Agent’s Actions. In exercising rights and remedies with respect to the
Collateral after the occurrence and during the continuance of any Event of Default, the Collateral
Agent shall, pursuant to the terms of Section 6.01 of the Indenture, enforce (or refrain
from enforcing) the provisions of the Collateral Documents in respect of the Collateral and
exercise (or refrain from exercising) remedies thereunder or any such rights and remedies, all in
such order and in such manner as the Collateral Agent may determine in accordance with Section
6.01 of the Indenture.

          (b) Use of Premises and Intellectual Property. The Collateral Agent or its designee
may (i) enter any Pledgor’s premises and, until the Collateral Agent completes the enforcement of
its rights in the Collateral, take exclusive possession of such premises or place custodians in
exclusive control thereof, remain on such premises and use the same and the Equipment for the
purpose of (A) completing any work in process, preparing Collateral for disposition and disposing
thereof and (B) collecting Collateral Obligations, and (ii) in the exercise of its rights under
this Agreement (x) use any Pledgor’s Intellectual Property to the extent of the rights of such
Pledgor therein, and each Pledgor hereby grants a license to the Collateral Agent for such purpose,
subject to the consent, if required, of any licensor, franchisor or other third Person or (y) on
demand cause the security interest in such Intellectual Property to become an assignment, transfer
and conveyance of such Intellectual Property to the Collateral Agent.

          (c) Directors, Officers and Employees. The Collateral Agent may retain any Pledgor’s
directors, officers and employees, in each case upon such terms as the Collateral Agent and any
such Person may agree, notwithstanding the provisions of any employment, confidentiality or
non-disclosure agreement between any such Person and such Pledgor and such Pledgor hereby waives
its rights under any such agreement and consents to each such retention.

          (d) Power of Sale. The Collateral Agent (i) may sell the Collateral in one or more
parcels at public or private sale, at any of its offices or elsewhere, for cash, on credit or for
future delivery, and at such price or prices and upon such other terms as it may deem commercially
reasonable, (ii) shall not be obligated to make any sale of Collateral regardless of notice of sale
having been given, (iii) restrict the prospective bidders or purchasers to persons who will
represent and agree that they are purchasing the Investment Property for their own account and not
with a view to the distribution of the same, and (iv) may adjourn any public or private sale from
time to time by announcement at the time and place fixed therefor, and such sale may, without
further notice, be made at the time and place to which it was so adjourned. Any secured party may
bid or purchase to the extend permitted by law free from any right held by a Pledgor the Collateral
or any part thereof offered for sale and may pay for the same by

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offsetting any claim against such Pledgor held by the secured party against the purchase price without further liability to such
Pledgor.

          (e) Foreclosure. The Collateral Agent, instead of exercising the power of sale
conferred upon it by Section 5.02(d) and applicable Law, may proceed by a suit or suits at
law or in equity to foreclose the Security Interest and sell the Collateral, or any portion
thereof, under a judgment or a decree of a court or courts of competent jurisdiction.

          (f) Receiver. The Collateral Agent may obtain the appointment of a receiver of the
Collateral and each Pledgor consents to and waives any right to notice of such appointment.

          (g) Bank Accounts. The Collateral Agent, with respect to all Bank Accounts, and each
Bank Account Bank, with respect to the Bank Account maintained with that Bank Account Bank, may do
either or both of the following: (i) refuse to permit further withdrawals and transfers (including
withdrawals and transfers of cash, securities, instruments and other property, but excluding all
withdrawals for payment of wages earned and related withholding and benefit amounts to be paid to
third parties as required by law) from such accounts and (ii) exercise all other rights hereunder
with respect thereto and with respect to the property that is credited to such accounts that the
Collateral Agent could exercise with respect to other Collateral, including, in the case of each
Bank Account Bank, rights, including those under Section 5.03(c), that such Bank Account
Bank would have with respect to a Bank Account maintained with it if such Bank Account Bank were
the Collateral Agent. In exercising such rights, each such Bank Account Bank shall be entitled to
all of the rights of the Collateral Agent under the Collateral Documents.

     Section 5.03 Collateral Proceeds.

          (a) Collections by Pledgors. The Collateral Agent may, by notice to a Pledgor, direct
it to, and thereupon such Pledgor shall, receive all proceeds of Collateral in trust for the
Collateral Agent, not commingle the same with any other property or funds of such Pledgor and,
unless the Collateral Agent shall have otherwise instructed such Pledgor, deliver or cause to be
delivered all such proceeds in the exact form received, together with any necessary endorsements,
to the Collateral Agent or to such Person or Persons as the Collateral Agent may designate.

          (b) Notification. The Collateral Agent may notify, or request a Pledgor to notify, in
writing or otherwise, (i) each Collateral Debtor to make payment directly to the Collateral Agent
and (ii) each Person maintaining any Bank Account or Securities Account subject to a Control
Agreement or similar arrangement, including the BNY Securities Account, to hold or otherwise
dispose of all amounts then or thereafter credited to, deposited in or made subject to such Bank
Account, Securities Account, BNY Securities Account or other arrangement as the Collateral Agent
may direct. If, notwithstanding the giving of any notice, any such Person shall make payments to
such Pledgor, such Pledgor shall hold all such payments it receives in trust for the Collateral
Agent, without commingling the same with other funds or property of such Pledgor or any other
Person, and shall deliver the same to the Collateral Agent immediately upon receipt by such Pledgor
in the identical form received, together with any necessary endorsements.

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          (c) Collateral Agent’s Rights with Respect to Proceeds and Other Collateral. All
payments and other deliveries received by or for the account of the Collateral Agent from time to
time pursuant to Section 5.03(a) or (b), together with the proceeds of all other
Collateral from time to time held by or for the account of the Collateral Agent (whether as a
result of the exercise by the Collateral Agent its rights under Section 5.02(d) or
(e), or Section 5.06 pursuant to the applicable Control Agreement, the Indenture or
otherwise) and all Bank Accounts (including all amounts credited from time to time thereto and all
cash, securities, instruments and other property represented by such credits) may, at the election
of the Collateral Agent, (i) be or continue to be held by the Collateral Agent, or any Person
designated by the Collateral Agent to receive or hold the same, as Collateral, (ii) be applied as
provided in Section 5.01 or (iii) be disposed of as provided in Section 5.02(d) and
(e) and Section 5.06.

          (d) Enforcement by Collateral Agent. The Collateral Agent may, without notice to the
Pledgors and at such time or times as the Collateral Agent in its sole discretion may determine,
exercise any or all of a Pledgor’s rights in, to and under, or in any way connected with or related
to, any or all of the Collateral, including (i) demanding and enforcing payment and performance of,
and exercising any or all of such Pledgor’s rights and remedies with respect to the collection,
enforcement or prosecution of, any or all of the Collateral Obligations, in each case by legal
proceedings or otherwise, (ii) settling, adjusting, compromising, extending, renewing, discharging
and releasing any or all of, and any legal proceedings brought to collect or enforce any or all of,
the Collateral Obligations, (iii) preparing, filing and signing the name of such Pledgor on (A) any
proof of claim or similar document to be filed in any bankruptcy or similar proceeding involving
any Collateral Debtor and (B) any notice of lien, assignment or satisfaction of lien, or similar
document in connection with any Collateral Obligation, and (iv) using the information recorded on
or contained in any data processing equipment and computer hardware and software relating to the
Collateral Obligations to which such Pledgor has access.

          (e) Adjustments. The Collateral Agent may settle or adjust disputes and claims
directly with Collateral Debtors for amounts and on terms that the Collateral Agent (subject to the
terms of Section 6.02(m) of the Indenture) considers advisable and in all such cases only
the net amounts received by the Collateral Agent in payment of such amounts, after deduction of
out-of-pocket costs and expenses of collection, including reasonable attorney’s fees, shall be
subject to the other provisions of this Agreement. Each Pledgors shall have no further right under
Section 4.07, Section 4.11 or otherwise to make any such settlements or adjustments
or to accept any returns of merchandise.

     Section 5.04 Inventory; Equipment and Other Goods.

          (a) Entry. The Collateral Agent may enter upon any premises in which any Inventory or
Equipment or Other Goods may be located and take, or place custodians in, exclusive, physical
possession of any or all thereof and maintain such possession on such premises or move the same or
any part thereof to such other place or places as the Collateral Agent shall choose.

          (b) Assembly. Upon the request of the Collateral Agent, each Pledgor shall assemble
the Inventory, Equipment and the Other Goods and maintain or deliver it into the possession of the
Collateral Agent or of any other Person designated by the Collateral Agent at

17

 

such place or places as the Collateral Agent or such other Person may designate and as are reasonably convenient to both
the Collateral Agent or such other Person and such Pledgor.

          (c) Warehousing. The Collateral Agent may cause any or all of the Inventory and the
Equipment and the Other Goods to be placed in a public or field warehouse.

     Section 5.05 Intellectual Property. The Collateral Agent may exercise any or all of
any Pledgor’s rights in, to and under, or in any way connected with or related to, any or all
Intellectual Property, including (a) pursuing any or all pending Intellectual Property applications
and (b) on a worldwide or such other basis as the Collateral Agent may determine, granting or
issuing exclusive and non-exclusive licenses relating to any or all of the Intellectual Property.
Each Pledgor agrees to cooperate with the Collateral Agent and provide the Collateral Agent with
any relevant facts or documents necessary for carrying out the purposes of this Section
5.05.

     Section 5.06 Restricted Offering Dispositions. 

          In connection with any sale of any of the Securities and Instruments that are Collateral, the
Collateral Agent may, at its election, comply with any limitation or restriction (including any
restrictions on the number of prospective bidders and purchasers or any requirement that they have
certain qualifications or that they represent and agree that they are purchasing for their own
account for investment and not with a view to the distribution or resale of such Securities and
Investments) as it may be advised by its counsel or the Holders (pursuant to Section
6.02(m) of the Indenture) is necessary in order to avoid any violation of applicable Law or to
obtain any Governmental Approval, and such compliance shall not result in such sale being
considered or deemed not to have been made in a commercially reasonable manner notwithstanding that
absent such restrictions a higher price might otherwise have been obtained, nor shall any Secured
Party be liable nor accountable to any Pledgor for any discount allowed by reason of the fact that
such Securities and Instruments are sold in compliance with any such limitation or restriction. A
private sale of which notice shall have been published in accordance with applicable “no action”
letters published by the SEC, and that otherwise complies with such letters, shall be deemed to
constitute a “public disposition” within the meaning of Section 9-610(c)(1) of the UCC. The
Collateral Agent has no obligation whatsoever to file any registration statement with any
securities regulatory authority.

     Section 5.07 Notice of Disposition of Collateral. Any notice to the Pledgors of
disposition of Collateral may be in the form of Schedule 5.07.

ARTICLE 6

MISCELLANEOUS

     Section 6.01 Expenses of Each Pledgor’s Agreements and Duties. Subject to the terms
of the Financing Documents, the terms, conditions, covenants and agreements to be observed or
performed by each Pledgor under the Collateral Documents shall be observed or performed by it at
its sole cost and expense.

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     Section 6.02 Collateral Agent’s Right to Perform on a Pledgor’s Behalf. If a Pledgor
shall fail to observe or perform any of the terms, conditions, covenants and agreements to be
observed or performed by it under the Collateral Documents, the Collateral Agent may (but shall not
be obligated to) do the same or cause it to be done or performed or observed, either in its name or
in the name and on behalf of such Pledgor, and such Pledgor hereby authorizes the Collateral Agent
so to do.

     Section 6.03 Collateral Agent’s Right to Use Agents and to Act in Name of the
Pledgors. The Collateral Agent may exercise its rights and remedies under the Collateral
Documents through an agent or other designee and, in the exercise thereof, the Collateral Agent or
any such other Person may act in its own name or in the name and on behalf of any Pledgor.

     Section 6.04 No Interference, Compensation or Expense. The Collateral Agent may
exercise its rights and remedies under the Collateral Documents (a) without resistance or
interference by the Pledgors, (b) without payment of any rent, license fee or compensation of any
kind to the Pledgors and (c) for the account, and at the expense, of the Pledgors.

     Section 6.05 Limitation of Obligations with Respect to Collateral. (a) Neither the
Collateral Agent nor any other Secured Party shall have any obligation to protect or preserve any
Collateral or to preserve rights pertaining thereto other than the obligation to use reasonable
care in the custody and preservation of any Collateral in its actual possession. The Collateral
Agent shall be deemed to have exercised reasonable care in the custody and preservation of any
Collateral in its possession if such Collateral is accorded treatment substantially equal to that
which the Collateral Agent accords its own property. The Collateral Agent shall be relieved of all
responsibility for any Collateral in its possession upon surrendering it, or tendering surrender of
it, to the Pledgors.

          (b) Nothing contained in the Collateral Documents shall be construed as requiring or
obligating the Collateral Agent or any other Secured Party, and neither the Collateral Agent nor
any other Secured Party shall be required or obligated, to (i) make any demand, or to make any
inquiry as to the nature or sufficiency of any payment received by it, or to present or file any
claim or notice or take any action, with respect to any Collateral Obligation or any other
Collateral or the monies due or to become due thereunder or in connection therewith, (ii) ascertain
or take action with respect to calls, conversions, exchanges, maturities, tenders, offers or other
matters relating to any Collateral, whether or not the Collateral Agent or any other Secured Party
has or is deemed to have knowledge or notice thereof, (iii) take any necessary steps to preserve
rights against any prior parties with respect to any Collateral or (iv) notify the Pledgors of any
decline in the value of any Collateral.

     Section 6.06 Rights of Collateral Agent under UCC and Applicable Law. The Collateral
Agent shall have, with respect to the Collateral, in addition to all of its rights and remedies
under the Collateral Documents, (a) the rights and remedies of a secured party under the UCC,
whether or not the UCC would otherwise apply to the Collateral in question, and (b) the rights and
remedies of a secured party under all other applicable Law.

     Section 6.07 Waivers of Rights Inhibiting Enforcement. Each Pledgor waives (a) any
claim that, as to any part of the Collateral, a public sale, should the Collateral Agent elect so
to

19

 

proceed, is, in and of itself, not a commercially reasonable method of sale for such Collateral,
(b) the right to assert in any action or proceeding between it and the Collateral Agent any offsets
or counterclaims that it may have, (c) except as otherwise provided in any of the Collateral
Documents, TO THE EXTENT PERMITTED BY APPLICABLE LAW, NOTICE OR JUDICIAL HEARING IN CONNECTION WITH
THE COLLATERAL AGENT’S TAKING POSSESSION OR DISPOSITION OF ANY OF THE COLLATERAL INCLUDING ANY AND
ALL PRIOR NOTICE AND HEARING FOR ANY PREJUDGMENT REMEDY OR REMEDIES AND ANY SUCH RIGHT THAT SUCH
PLEDGOR WOULD OTHERWISE HAVE UNDER THE CONSTITUTION OR ANY STATUTE OF THE UNITED STATES OR OF ANY
STATE, AND ALL OTHER REQUIREMENTS AS TO THE TIME, PLACE AND TERMS OF SALE OR OTHER REQUIREMENTS
WITH RESPECT TO THE ENFORCEMENT OF THE COLLATERAL AGENT’S RIGHTS HEREUNDER, (d) all rights (i) of
redemption, appraisement, valuation, stay and extension or moratorium and (ii) to the marshalling
of assets and (e) all other rights the exercise of which would, directly or indirectly, prevent,
delay or inhibit the enforcement of any of the rights or remedies under the Collateral Documents or
the absolute sale of the Collateral, now or hereafter in force under any applicable Law, and each
Pledgor, for itself and all who may claim under it, insofar as it or they now or hereafter lawfully
may, hereby waive the benefit of all such laws and rights.

     Section 6.08 Power of Attorney. (a) In addition to the other powers granted to the
Collateral Agent by each Pledgor under the Collateral Documents, each Pledgor hereby appoints the
Collateral Agent, and any other Person that the Collateral Agent may designate, as such Pledgor’s
attorney-in-fact to act, in the name, place and stead of such Pledgor, only during an Event of
Default, in any way in which such Pledgor itself could do, with respect to each of the following:
(i) endorsing such Pledgor’s name on (A) any checks, notes, acceptances, money orders, drafts or
other forms of payment, (B) any proxies, documents, instruments, notices, freight bills, bills of
lading or other documents or agreements relating to the Collateral, (C) schedules and assignments
of Collateral Obligations and (D) notices of assignment, financing statements and other public
records; (ii) claiming for, adjusting, and instituting legal proceedings to collect, any amounts
payable under insurance, and applicable loss payable endorsements, required to be maintained under
any of the Collateral Documents; (iii) taking any actions or exercising any rights, powers or
privileges that such Pledgor is entitled to take or exercise and that, under the terms of any of
the Collateral Documents, the Collateral Agent is authorized to take or exercise; (iv) doing or
causing to be done any or all things necessary or, in the determination of the Collateral Agent or
the Secured Parties, desirable to observe or perform the terms, conditions, covenants and
agreements to be observed or performed by such Pledgor under the Collateral Documents and otherwise
to carry out the provisions of the Collateral Documents; and (v) notifying the post office
authorities to change the address for delivery of such Pledgor’s mail to an address designated by
the Collateral Agent, and receiving, opening and disposing of all mail addressed to such Pledgor
(with all mail not constituting, evidencing or relating to the Collateral to be forwarded by the
Collateral Agent to such Pledgor). Each Pledgor hereby ratifies and approves all acts of the
attorney.

          (b) To induce any third Person to act under this Section 6.08, each Pledgor hereby
agrees that any third Person receiving a duly executed copy or facsimile of this Agreement may act
under this Section 6.08, and that the termination of this Section 6.08 shall be
ineffective as to such third Person unless and until actual notice or knowledge of such

20

 

termination shall have been received by such third Person, and such Pledgor, on behalf of itself and its
successors and assigns, hereby agrees to indemnify and hold harmless any such third Person from and
against any and all claims that may arise against such third Person by reason of such third Person
having relied on the provisions of this Section 6.08.

     Section 6.09 Nature of Pledgor’s Obligations. Each Pledgor’s grant of the Security
Interest as security for the Secured Obligations (a) is absolute and unconditional, (b) is
unlimited in amount except as provided in Section 6.13, (c) shall be a continuing security
interest securing all present and future Secured Obligations and all promissory notes and other
documentation given in extension or renewal or substitution for any of the Secured Obligations and
(d) shall be irrevocable.

     Section 6.10 No Release of Pledgors. The Security Interest shall not be limited or
terminated, nor shall the Secured Obligations secured thereby be reduced or limited, nor shall any
Pledgor be discharged of any of its Obligations under the Collateral Documents, for any reason
whatsoever (other than, subject to Section 6.13, 6.15 and 6.19, the
payment, observance and performance of the Secured Obligations), including (and whether or not the
same shall have occurred or failed to occur once or more than once and whether or not such Pledgor
shall have received notice thereof):

          (a) (i) any increase in the principal amount of, or interest rate applicable to, (ii) any
extension of the time of payment, observance or performance of, (iii) any other amendment or
modification of any of the other terms and provisions of, (iv) any release, composition or
settlement (whether by way of acceptance of a plan of reorganization or otherwise) of, (v) any
subordination (whether present or future or contractual or otherwise) of, or (vi) any discharge,
disallowance, invalidity, illegality, voidness or other unenforceability of, the Secured
Obligations;

          (b) (i) any failure to obtain, (ii) any release, composition or settlement of, (iii) any
amendment or modification of any of the terms and provisions of, (iv) any subordination of, or (v)
any discharge, disallowance, invalidity, illegality, voidness or other unenforceability of, any
guaranties of the Secured Obligations;

          (c) (i) any failure to obtain or any release of, (ii) any failure to protect or preserve,
(iii) any release, compromise, settlement or extension of the time of payment of any obligations
constituting, (iv) any failure to perfect or maintain the perfection or priority of any Lien upon,
(v) any subordination of any Lien upon, or (vi) any discharge, disallowance, invalidity,
illegality, voidness or other unenforceability of any Lien or intended Lien upon, any collateral
now or hereafter securing the Secured Obligations or any guaranties thereof;

          (d) any termination of or change in any relationship between any Pledgor and the Borrower,
including any such termination or change resulting from a change in ownership of such Pledgor or
the Borrower or from the cessation of any commercial relationship between the Pledgor and the
Borrower;

          (e) any exercise of, or any election not or failure to exercise, delay in the exercise of,
waiver of, or forbearance or other indulgence with respect to, any right, remedy or

21

 

power available to the Collateral Agent or any other Secured Party, including (i) any election not or failure to
exercise any right of setoff, recoupment or counterclaim, (ii) any election of remedies effected by
the Secured Parties, including the foreclosure upon any real estate constituting collateral,
whether or not such election affects the right to obtain a deficiency judgment, and (iii) any
election by the Secured Parties in any proceeding under the Bankruptcy Code of the application of
Section 1111(b)(2) of such Code; and

          (f) Any other act or failure to act or any other event or circumstance that (i) varies the
risk of any Pledgor hereunder or (ii) but for the provision hereof, would, as a matter of statute
or rule of Law or equity, operate to limit or terminate the Security Interest or to reduce or limit
the Secured Obligations secured thereby or to discharge any Pledgor from any of its Obligations
under the Collateral Documents.

     Section 6.11 Certain Other Waivers. Each Pledgor waives:

          (a) any requirement, and any right to require, that any right or power be exercised or any
action be taken against the Borrower, any guarantor or any collateral for the Secured Obligations;

          (b) all defenses to, and all setoffs, counterclaims and claims of recoupment against, the
Secured Obligations that may at any time be available to the Borrower or any guarantor;

          (c) (i) notice of acceptance of and intention to rely on the Collateral Documents, (ii) notice
of the incurrence or renewal of any Secured Obligations, (iii) notice of any of the matters
referred to in Section 6.10 and (iv) all other notices that may be required by applicable
Law or otherwise to preserve any rights against each Pledgor under the Collateral Documents,
including any notice of default, demand, dishonor, presentment and protest;

          (d) diligence on the part of the Collateral Agent or any Secured Party in exercising its
remedies hereunder;

          (e) any defense based upon, arising out of or in any way related to (i) any claim that any
sale or other disposition of any collateral for the Secured Obligations was not conducted in a
commercially reasonable fashion or that a public sale, should the Collateral Agent have elected to
so proceed, was, in and of itself, not a commercially reasonable method of sale, (ii) any claim
that any election of remedies by the Secured Parties, including the exercise by the Collateral
Agent or any other Secured Party of any rights against any collateral, impaired, reduced, released
or otherwise extinguished any right that such Pledgor might otherwise have had against the Borrower
or any guarantor or against any collateral, including any right of subrogation, exoneration,
reimbursement or contribution or right to obtain a deficiency judgment, (iii) any claim based upon,
arising out of or in any way related to any of the matters referred to in Section 6.10 and
(iv) any claim that the Collateral Documents should be strictly construed against the Secured
Parties; and

          (f) ALL OTHER DEFENSES UNDER APPLICABLE LAW THAT WOULD, BUT FOR THIS CLAUSE (f), BE AVAILABLE
TO ANY PLEDGOR AS (i) A DEFENSE AGAINST THE ENFORCEMENT OF THE SECURITY INTEREST, (ii) A REDUCTION
OR

22

 

LIMITATION OF THE SECURED OBLIGATIONS SECURED THEREBY OR (iii) A DEFENSE AGAINST ITS OBLIGATIONS
UNDER THE COLLATERAL DOCUMENTS.

     Section 6.12 Independent Credit Evaluation. Each Pledgor has independently, and
without reliance on any information supplied by the Secured Parties, taken, and will continue to
take, whatever steps it deems necessary to evaluate the financial condition and affairs of the
Borrower, and neither the Collateral Agent nor any other Secured Party shall have any duty to
advise such Pledgor of information at any time known to it regarding such financial condition or
affairs.

     Section 6.13 Limitation on Amount of Obligations Secured. It is the intention of each
Pledgor and the Collateral Agent that the Secured Obligations secured by the Security Interest and
the obligations of such Pledgor under the Collateral Documents shall be in, but not in excess of,
the maximum amount permitted by applicable Law. To that end, but only to the extent that the
Security Interest would otherwise be void, voidable or otherwise unenforceable, the amount of the
Secured Obligations secured by the Security Interest shall be limited to the maximum amount that
would not make the Security Interest void, voidable or otherwise unenforceable. This Section
6.13 is intended to preserve the rights of the Collateral Agent under the Collateral Documents
to the maximum extent permitted by applicable Law, and neither a Pledgor nor any other Person shall
have any right under this Section 6.13 that it would not otherwise have under applicable
Law.

     Section 6.14 Continuance and Acceleration of Secured Obligations upon Certain Events.
If:

          (a) any Event of Default that the Indenture states is to result in the automatic acceleration
of any Secured Obligations shall occur;

          (b) any injunction, stay or the like that enjoins any acceleration, or demand for the payment,
observance or performance, of any Secured Obligations that would otherwise be required or permitted
under the Financing Documents shall become effective; or

          (c) any Secured Obligations shall be or be determined to be or become discharged, disallowed,
invalid, illegal, void or otherwise unenforceable (whether by operation of any present or future
law or by order of any court or governmental agency);

          (d) then (i) such Secured Obligations shall, for all purposes of the Collateral Documents, be
deemed (A) in the case of clause (c), to continue to be outstanding and in full force and effect
notwithstanding the unenforceability thereof and (B) if such is not already the case, to have
thereupon become immediately due and payable and to have commenced bearing interest at the Default
Rate and (ii) the Collateral Agent may, with respect to such Secured Obligations, exercise all of
the rights and remedies under the Collateral Documents that would be available to it during an
Event of Default.

     Section 6.15 Recovered Payments. The Secured Obligations shall be deemed not to have
been paid, observed or performed, and each Pledgor’s obligations under the Collateral Documents in
respect thereof shall continue and not be discharged, to the extent that any payment, observance or
performance thereof by the Borrower or any guarantor, or out of the

23

 

proceeds of any other collateral, is recovered from or paid over by or for the account of any Secured Party for any
reason, including as a preference or fraudulent transfer or by virtue of any subordination (whether
present or future or contractual or otherwise) of the Secured Obligations, whether such recovery or
payment over is effected by any judgment, decree or order of any court or governmental agency, by
any plan of reorganization or by settlement or compromise by any Secured Party (whether or not
consented to by the Borrower, a Pledgor or any guarantor) of any claim for any such recovery or
payment over. Each Pledgor hereby expressly waives the benefit of any applicable statute of
limitations and agrees that it shall be obligated hereunder with respect to any Secured Obligations
whenever such a recovery or payment over thereof occurs.

     Section 6.16 Evidence of Secured Obligations. The records of each Secured Party shall
be conclusive evidence of the Secured Obligations owing to it and of all payments, observances and
performances in respect thereof.

     Section 6.17 Binding Nature of Certain Adjudications. Each Pledgor shall be
conclusively bound by the adjudication in any action or proceeding, legal or otherwise, involving
any controversy arising under, in connection with, or in any way related to, any of the Secured
Obligations, and by a judgment, award or decree entered therein.

     Section 6.18 Subordination of Rights Against the Borrower, Guarantors and Other
Collateral.

          (a) Release of “Claims” Against the Borrower Resulting from the Collateral Documents.
Each Pledgor hereby releases the Borrower from all “claims” (as defined in section 101(4) of the
Bankruptcy Code) that such Pledgor might otherwise have against the Borrower, including any such
claims to which such Pledgor may be entitled as a result of any right of subrogation, exoneration
or reimbursement.

          (b) Subordination of Other Rights. All rights that each Pledgor may at any time have
against the Borrower, any guarantor or any other collateral for the Secured Obligations (including
rights of subrogation, exoneration, reimbursement and contribution and whether arising under
applicable Law or otherwise) are hereby expressly subordinated to the prior payment, observance and
performance in full of the Secured Obligations. Each Pledgor shall not enforce any of the rights,
or attempt to obtain payment or performance of any of the obligations, subordinated pursuant to
this Section 6.18(b) until the Secured Obligations have been paid, observed and performed
in full, except that such prohibition shall not apply to routine acts, such as the giving of
notices and the filing of continuation statements, necessary to preserve any such rights. If any
amount shall be paid to or recovered by such Pledgor (whether directly or by way of setoff,
recoupment or counterclaim) on account of any right or obligation subordinated pursuant to this
Section 6.18(b), such amount shall be held in trust by such Pledgor for the benefit of the
Secured Parties, not commingled with any of such Pledgor’s other funds and forthwith paid over to
the Collateral Agent, in the exact form received, together with any necessary endorsements, to be
applied and credited against, or held as security for, the Secured Obligations.

     Section 6.19 Termination of Security Interest. (a) The Security Interest in (i)
Collateral that each Pledgor is entitled to, and does, receive and retain, or withdraw, pursuant to

24

 

Section 2.02 and (ii) Collateral disposed of by such Pledgor in a disposition to which a
Section of this Agreement, by its express terms, does not apply shall terminate, and such item of
Collateral shall be released therefrom, immediately upon such receipt, withdrawal or disposition,
without any further action by the Collateral Agent; provided, however, that such
release shall not apply to any other Collateral, including the proceeds of the item of Collateral
so disposed of.

          (b) Security Interest and all of each Pledgor’s obligations under Article 1, Article 4 and
Article 5 shall terminate upon the latest of (a) the repayment, to the extent due, and, to the
extent not due, the satisfaction or securing, in a manner acceptable to the Collateral Agent, of
the Secured Obligations, (b) the maturity of the Bonds and (c) the discharge, dismissal with
prejudice, settlement, release or other termination of any other Financing Document Related Claims
that may be pending or threatened against the Indemnified Parties.

          (c) In the absence of a Default or an Event of Default, the Collateral Agent shall be fully
justified in failing or refusing to take any action under this Agreement or any other Collateral
Document unless it shall first receive legal advice or the concurrence of the Holders pursuant to
Section 6.02(m) of the Indenture prior to the discharge of obligations, in accordance with
the terms hereof and the Indenture, or it shall first be indemnified or receive security to its
satisfaction by the Secured Parties against any and all liability and expense that may be incurred
by it by reason of taking or continuing to take any such action.

     Section 6.20 Designation of Notice. No notice shall be effective under Section
4.01(a), (b), (c) or (d) unless it is specifically designated, in the
case of a notice under Section 4.01(a), “Notice of Proposed Merger” and in the case of a
notice under Section 4.01(b) “Notice of Change of Organizational Identification Number,
Name, Identity or Corporate Structure”.

     Section 6.21 Extension of Payment Dates. Whenever any payment to any Secured Party
under the Collateral Documents would otherwise be due (except by reason of acceleration) on a day
that is not a Business Day, such payment shall instead be due on the next succeeding Business Day.
If the date any payment under the Collateral Documents is due is extended (whether by operation of
any Collateral Document, applicable Law or otherwise), such payment shall bear interest for such
extended time at the rate of interest applicable hereunder.

     Section 6.22 GOVERNING LAW. THIS AGREEMENT SHALL, PURSUANT TO NEW YORK GENERAL
OBLIGATIONS LAW SECTION 5-1401, BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAW OF THE
STATE OF NEW YORK.

     Section 6.23 LIMITATION OF LIABILITY. NEITHER THE COLLATERAL AGENT NOR ANY OTHER
SECURED PARTY SHALL HAVE ANY LIABILITY WITH RESPECT TO, AND EACH PLEDGOR HEREBY WAIVES, RELEASES
AND AGREES NOT TO SUE FOR:

          ANY LOSS OR DAMAGE SUSTAINED BY SUCH PLEDGOR, OR ANY LOSS, DAMAGE, DEPRECIATION OR OTHER
DIMINUTION IN THE VALUE OF ANY COLLATERAL, THAT MAY OCCUR AS A RESULT OF, IN CONNECTION WITH, OR
THAT IS IN ANY WAY RELATED TO, (i) ANY ACT OR FAILURE TO ACT REFERRED

25

 

TO IN SECTION 6.10 OR (ii) ANY EXERCISE OF ANY RIGHT OR REMEDY UNDER THE COLLATERAL DOCUMENTS, EXCEPT, IN THE CASE OF
CLAUSE (ii), FOR ANY SUCH LOSS, DAMAGE, DEPRECIATION OR DIMINUTION TO THE EXTENT THAT THE SAME IS
DETERMINED BY A JUDGMENT OF A COURT THAT IS BINDING ON SUCH PLEDGOR AND SUCH SECURED PARTY, FINAL
AND NOT SUBJECT TO REVIEW ON APPEAL, TO BE THE RESULT OF ACTS OR OMISSIONS ON THE PART OF SUCH
SECURED PARTY CONSTITUTING (x) WILLFUL MISCONDUCT, (y) KNOWING VIOLATIONS OF LAW OR (z) SUCH
PERSON’S FAILURE TO OBSERVE ANY OTHER STANDARD APPLICABLE TO IT UNDER ANY OF THE OTHER PROVISIONS
OF THE COLLATERAL DOCUMENTS OR, BUT ONLY TO THE EXTENT NOT WAIVABLE THEREUNDER, APPLICABLE LAW.

     Section 6.24 Counterparts. Each Collateral Document may be signed in any number of
counterparts, each of which shall be an original, with the same effect as if the signatures thereto
were upon the same instrument.

     Section 6.25 Entire Agreement. This Agreement embodies the entire agreement among the
Pledgors, the Collateral Agent and the Secured Parties relating to the subject matter hereof and
supersedes all prior agreements, representations and understandings, if any, relating to the
subject matter hereof.

     Section 6.26 Successors and Assigns. All of the provisions of each Collateral
Document shall be binding upon and inure to the benefit of the Pledgors, the Collateral Agent and
the other Secured Parties and their respective successors and assigns.

     Section 6.27 Delivery of Opinions Authorized. Each Pledgor hereby acknowledges and
agrees that each Person that has rendered or may render an opinion, report or similar
communication, including legal opinions and accountant’s reports, to any Person in connection with
the Collateral Documents, has been and is hereby authorized and directed to so deliver such
opinion, report or communication.

     Section 6.28 Rights of Collateral Agent. In the performance of its obligations
hereunder, the Collateral Agent shall be entitled to all of the rights, benefits, protections and
immunities afforded to it pursuant to the Indenture and this Agreement. In no event shall the
Collateral Agent be liable for special, indirect or consequential loss or damage of any kind
whatsoever (including, but not limited to, lost profits), even if the Collateral Agent has been
advised of the likelihood of such loss or damage and regardless of the form of action.

ARTICLE 7

INTERPRETATION

     Section 7.01 Definitional Provisions.

          (a) Certain Terms Defined by Reference. (i) Except where the context clearly
indicates a different meaning, all terms defined in Article 1, 2A, 5, 8 or 9 of the UCC, as in
effect on the date of this Agreement, are used herein with the meanings therein ascribed to them;
such

26

 

terms include “account”, “chattel paper”, “commercial tort claim”, “commodity account”,
“commodity contract”, “control”, “deposit account”, “document”, “equipment”, “financial asset”,
“general intangibles”, “goods”, “instrument”, “inventory”, “investment property”, “leasehold
interest”, “lessor’s residual interest”, “letter of credit”, “letter-of-credit right”, “money”,
“payment intangible”, “proceeds”, “promissory note”, “registered organization”, “securities
account”, “security”, “security entitlement” and “security interest”. In addition, the terms
“account”, “collateral” and “security interest”, when capitalized, have the meanings specified in
subsection (b) below and the term “deposit account” includes an account evidenced by a certificate
of deposit.

          (ii) Except in the case of “Agreement”, “Collateral”, “Intellectual Property” and
“Security Interest” and as otherwise specified herein, all terms defined in the Indenture
are used herein with the meanings therein ascribed to them.

          (b) Other Defined Terms. For purposes of this Agreement:

          “Account” means an account.

          “Account Debtor” means a Person obligated on an Account.

          “Account Proceeds” means proceeds of an Account other than an Account representing the
sale or other disposition of Equipment pursuant to Section 4.21 of the Indenture.

          “Agreement” means this Pledge and Security Agreement, including all schedules, annexes
and exhibits hereto.

          “Bank Account” means (i) a deposit, custody, or other account (whether, in any case,
time or demand or interest or non-interest bearing and whether maintained at a branch or office
located within or without the United States) of each Pledgor listed on Schedule 7.01(b)-1,
(ii) all amounts from time to time credited to such account, (iii) all cash, financial assets and
other investment property, instruments, documents, chattel paper, general intangibles, accounts and
other property from time to time credited to such account or representing investments and
reinvestments of amounts from time to time credited to such account and (iv) all interest,
principal payments, dividends and other distributions payable on or with respect to, and all
proceeds of, (A) all property so credited or representing such investments and reinvestments and
(B) such account.

          “Bank Account Bank” means a Person with whom a Bank Account that is Collateral is
maintained.

          “BNY Securities Account” means the Securities Account (as defined in the Indenture)
described in Section 4.15(b) of the Indenture.

          “Bonds” shall refer to the $150,000,000 aggregate principal amount of Senior Secured
Floating Rate Bonds due 2012.

          “Chattel Paper” means chattel paper.

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          “Collateral” means each Pledgor’s Rights, WHETHER SUCH RIGHTS ARE NOW OR HEREAFTER
EXISTING, in each of the following items of property, whether, in the case of any item (a) NOW OR
HEREAFTER EXISTING, (b) SUCH PLEDGOR NOW OR HEREAFTER HAS RIGHTS THEREIN, (c) IT IS NOW
CONTEMPLATED, ANTICIPATED OR FORESEEABLE THAT SUCH ITEM WOULD BE COLLATERAL, (d) it is subject to
Article 8 or 9 of the UCC or is Collateral by reason of one or more than one of the following
clauses, AND WHEREVER THE SAME MAY BE LOCATED:

     (i) all Receivables;

     (ii) all General Intangibles;

     (iii) all Inventory;

     (iv) all Equipment;

     (v) all Other Goods;

     (vi) all Instruments;

     (vii)
all Investment Property Collateral;

     (viii)
all Chattel Paper;

     (ix) all Documents;

     (x) all (A) Letters of Credit and (B) Letter-of-Credit Rights;

     (xi)
all Commercial Tort Claims;

     (xii) all Material Contracts;

     (xiii) all Bank Accounts;

     (xiv) the BNY Securities Account;

     (xv) all rights (contractual and otherwise and whether constituting accounts, general
intangibles or investment property or financial assets) constituting, arising under,
connected with, or in any way related to, any or all Collateral;

     (xvi) all books, records, ledgercards, files, correspondence, computer programs, tapes,
disks and related data processing software (owned by each Pledgor or in which it has an
interest) that at any time evidence or contain information relating to any Collateral or are
otherwise necessary or helpful in the collection thereof or realization thereupon;

     (xvii) all goods and other property, whether or not delivered, (A) the sale, lease or
furnishing of which gives or purports to give rise to any Receivable, including all
merchandise returned or rejected by or repossessed from customers, or (B) securing any

28

 

Receivable, including all of each Pledgor’s rights as an unpaid vendor or lienor, including
stoppage in transit, replevin and reclamation with respect to such goods and other
properties;

     (xviii) all documents of title, policies and certificates of insurance, securities,
chattel paper and other documents or instruments evidencing or pertaining to any Collateral;

     (xix) all supporting obligations and other Liens on real or personal property, leases
and other agreements and property that in any way secure or relate to any Collateral, or are
acquired for the purpose of securing and enforcing any item thereof;

     (xx) all claims (including the right to sue or otherwise recover on such claims) (A) to
items referred to in the definition of Collateral, (B) under warranties relating to any
Collateral and (C) against third parties for (1)(aa) loss, destruction, requisition,
confiscation, condemnation, seizure, forfeiture or infringement of, or damage to, any
Collateral, (bb) payments due or to become due under leases, rentals and hires of any
Collateral, (cc) proceeds payable under or unearned premiums with respect to policies of
insurance relating to any Collateral and (2) breach of any Contract constituting Collateral;
and

     (xxi) all products and proceeds of Collateral in whatever form;

provided, that, if, under applicable Law, the attachment of the Security Interest in any
Contract would require the consent of any party thereto, other than a Pledgor, or would give any
such other party the right to terminate its obligations thereunder, such Contract shall (so long as
such consent has not been obtained) be deemed not to be Collateral, if, and only if, such other
party has notified each applicable Pledgor in writing that such other party intends to assert its
rights under such Contract that result from such attachment, and such Pledgor has given the
Collateral Agent a copy of such notice and of such Contract; provided further, that
in the absence of any such notice, such Contract shall continue to constitute Collateral; and
provided, finally, that the first proviso shall not affect, limit, restrict
or impair the grant by such Pledgor of, or the attachment of the Security Interest in, any property
with respect to which such required consent would be ineffective under applicable Law.

          The inclusion of “proceeds” of Collateral in the definition of “Collateral” shall not be
deemed a consent by the Collateral Agent to any sale or other disposition of any Collateral not
otherwise specifically permitted by the terms hereof.

          “Collateral Agent” means The Bank of New York Trust Company, N.A., acting for the
benefit of itself as Collateral Agent and as the agent for and representative (within the meaning
of Section 9-102(a)(72)(E) of the UCC) of the other Secured Parties.

          “Collateral Debtor” means a Person (including an issuer of any share of capital stock
or other unit of ownership interest constituting Investment Property Collateral) obligated on,
bound by, or subject to, a Collateral Obligation.

29

 

          “Collateral Documents” means (i) this Agreement and (ii) all other agreements,
documents and instruments related to, arising out of, or in any way connected with, (A) this
Agreement, (B) any other agreement, document or instrument referred to in this clause (ii), or (C)
any of the transactions contemplated by this Agreement, the Indenture, the Bonds, the Purchase
Agreements or any Subsidiary Guarantee.

          “Collateral Obligation” means a Liability that is Collateral and includes any such
constituting or arising under any Receivable, General Intangible, Instrument, Investment Property
Collateral or Letter-of-Credit Rights and all supporting obligations..

          “Commercial Tort Claim” means a commercial tort claim listed on Schedule
7.01(b)-2.

          “Commodity Account” means (i)(A) each commodity account listed on Schedule
4.19(a) and (B) each commodity account, whether or not listed on Schedule 4.19(a),
under the control of the Collateral Agent, (ii) each commodity account that is a successor to (A) a
commodity account referred to in clause (i) or (B) a Commodity Account which is such by virtue of
this clause (ii) and (iii) all cash, financial assets, instruments, documents, chattel paper,
general intangibles, accounts and other property from time to time credited to a Commodity Account.

          “Commodity Contract” means (i) a commodity contract listed on Schedule
4.19(a), and (ii) a commodity contract, whether or not listed on Schedule 4.19(a), of
the same class or series and payable by one of the same Persons as those listed on Schedule
4.19(a) under the control of the Collateral Agent.

          “Constituent Collateral” means in the case of Collateral that is Investment Property,
Collateral that consists of commodity accounts, commodity contracts, securities, securities
accounts and security entitlements that are identified as Constituent Collateral on Schedule
7.01(b)-3.

          “Contract” means (i) any agreement (whether bi-lateral or uni-lateral or executory or
non-executory and whether a Person entitled to rights thereunder is so entitled directly or as a
third-party beneficiary), including an indenture, lease or license, (ii) any deed or other
instrument of conveyance, (iii) any certificate of incorporation or charter and (iv) any bylaw.

          “Control Agreement” means, as applied to any Investment Property, Bank Account or
Letter-of-Credit Right, a Contract, substantially in the form of Exhibit I to the Indenture
or in form and substance approved by the Collateral Agent in its sole discretion (in accordance
with Section 6.02(m) of the Indenture), pursuant to which the Collateral Agent is granted
control over such Investment Property.

          “Copyrights” means (i) (A) all copyrights now existing or hereafter created or
acquired, (B) all registrations and recordings thereof and (C) all applications in connection
therewith pending, at the time in question, in any Intellectual Property Recording Office,
including the Copyrights listed on Schedule 3.03 and (ii) all reissues, divisions,
continuations, continuations-in-part, extensions and renewals of each Copyright, including
Copyrights which are such by virtue of this clause (ii).

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          “Copyright Licenses” means all Contracts naming a Pledgor as licensor or licensee and
granting any right under any Copyright.

          “Documents” means documents.

          “Equipment” means all equipment.

          “Extraordinary Distributions” means (in each case whether or not in cash) all
dividends, interest, principal payments and other distributions and other payments (including cash
and securities payable in connection with calls, conversions, redemptions and the like) on or in
respect of, and all proceeds (including cash and securities receivable in connection with tender or
other offers) of, Investment Property Collateral other than Ordinary Distributions.

          “Financing Document Related Claim” means any claim or dispute (whether arising under
applicable Law, under contract or otherwise, and, in the case of any proceeding relating to any
such claim or dispute, whether civil, criminal, administrative or otherwise) in any way arising out
of, related to, or connected with, the Financing Documents, the relationships established
thereunder or any actions or conduct thereunder or with respect thereto, whether such claim or
dispute arises or is asserted before or after the date of this Agreement or before or after the
date on which all Obligations have been paid or satisfied in full.

          “General Intangibles” means all general intangibles.

          “Governmental Approval” means any authorization, consent, approval, license or
exemption (or the like) of or from, or action by, any Governmental Authority.

          “Indenture” means the Indenture, dated as of November 16, 2007, among Molecular
Insight Pharmaceuticals, Inc., the subsidiary guarantors party from time to time thereto and The
Bank of New York Trust Company, N.A., as Trustee and Collateral Agent.

          “Instrument” means (i)(A) each instrument listed on Schedule 4.19(a) and (B)
each instrument acquired by a Pledgor pursuant to its obligations under Section 4.19, (ii)
each instrument, whether or not listed on Schedule 4.19(a), of the same class or series and
payable by one of the same makers or drawers as those listed on Schedule 4.19(a), in the
possession of (A) the Collateral Agent, or (B) a Person acting on behalf of the Collateral Agent or
who has acknowledged that it holds such instrument for the Collateral Agent, and (iii) each
instrument whether or not listed on Schedule 4.19(a), of the same class or series and
payable by one of the same makers or drawers as those listed on Schedule 4.19(a), delivered
to or for the account of such Pledgor by the Collateral Agent or any such Person for a purpose
contemplated by Section 9-312(g) of the UCC.

          “Intellectual Property” means (i) (A) Patents and Patent Licenses, (B) Trademarks and
Trademark Licenses, and (C) Copyrights and Copyright Licenses, in each case whether registered,
unregistered or pending registration and whatever the Intellectual Property Recording Office at
which the same may be registered or pending, (ii) all reissues, divisions, continuations,
continuations-in-part and extensions of any Intellectual Property referred to in clause
(i) or this clause (ii), and (iii) all rights relating to all Intellectual Property which is such by virtue of
clause

31

 

(i), (ii) or this clause (iii), including rights under applications wherever pending and
licenses relating thereto.

          “Intellectual Property Recording Office” means, as appropriate, the United States
Patent and Trademark Office, the United States Copyright Office or any similar office or agency of
the United States, any state thereof, or any other country or political subdivision thereof.

          “Inventory” means all inventory.

          “Investment Property” means all investment property.

          “Investment Property Collateral” means: (i) (A) all Securities; (B) all Securities
Accounts; (C) all Security Entitlements; (D) all Commodity Accounts; (E) all Commodity Contracts;
(F) all Investment Property; (ii) all replacements and substitutions for any Investment Property
Collateral that is (whether by virtue of clause (i) or this clause (ii)) Investment Property
Collateral; and (iii) the certificates, if any, representing any of the foregoing.

          “Jurisdiction” means, in the case of a securities intermediary, its jurisdiction
determined in accordance with Section 8-110(e), and, in the case of a commodity intermediary, its
jurisdiction determined in accordance with Section 9-305(b), of the UCC.

          “Letter of Credit” means a letter of credit listed on Schedule 7.01(b)-4.

          “Letter-of-Credit Right” means a letter-of-credit right under a letter of credit
listed on Schedule 7.01(b)-4.

          “Liability” of any Person means (in each case, whether with full or limited recourse)
any indebtedness, liability, obligation, covenant or duty of or binding upon, or any term or
condition to be observed by or binding upon, such Person or any of its assets, of any kind, nature
or description, direct or indirect, absolute or contingent, due or not due, contractual or
tortious, liquidated or unliquidated, whether arising under Contract, applicable Law, or otherwise,
whether now existing or hereafter arising, and whether for the payment of money or the performance
or non-performance of any act.

          “Location” means, in the case of each Pledgor, its location as determined in
accordance with Section 9-307 of the UCC.

          “Material Contract” means, with respect to any Person, each contract to which such
Person is a party (other than the Financing Documents) for which (a) aggregate payments exceed
$1,000,000 per year or $5,000,000 in the aggregate or (b) breach, nonperformance, cancellation or
failure to renew could reasonably be expected to have a Material Adverse Effect, or (c) has a Fair
Market Value in excess of $1,000,000 in the aggregate and relates to a Primary Product.

          “Ordinary Distributions” means cash dividends to the extent paid out of retained
earnings, and interest paid in cash, in each case with respect to Investment Property Collateral,
except to the extent that any such dividend is made in connection with partial or total liquidation

32

 

or a reduction of capital, or any such interest is penalty interest, or, in each case, to the
extent the same is not in the ordinary course.

          “Other Goods” means all goods other than Inventory and Equipment.

          “Patents” means (i) (A) all patents and patentable inventions, now existing or
hereafter acquired or invented, (B) all registrations and recordings thereof and (C) all
applications in connection therewith pending, at the time in question, in any Intellectual Property
Recording Office, including the Patents listed on Schedule 3.03 and (ii) all reissues,
divisions, continuations, continuations-in-part, extensions and renewals of each Patent, including
Patents which are such by virtue of this clause (ii).

          “Patent Licenses” means all Contracts naming any Pledgor as licensor or licensee and
granting any right to use any Patent.

          “Payment Intangible” means a payment intangible.

          “Payment Right” means all rights to the payment of money under, but only in each case
to the extent the same constitutes Collateral, (i) Accounts (other than Accounts representing the
sale or other disposition of Equipment and Other Goods pursuant to Section 4.21of the
Indenture, (ii) Payment Intangibles, and (iii) Letter-of-Credit Rights.

          “Pledgor” has the meaning set forth in the recitals hereto.

          “Receivable” means an Account.

          “Representation and Warranty” means each representation or warranty made pursuant to
or under (i) Article 2, Article 3 or any other provision of this Agreement, (ii)
any of the other Collateral Documents or (iii) any amendment to, or waiver of rights under, this
Agreement or any of the other Collateral Documents, WHETHER OR NOT, IN THE CASE OF ANY
REPRESENTATION OR WARRANTY REFERRED TO IN CLAUSE (i), (ii) OR (iii) OF THIS DEFINITION (EXCEPT, IN
EACH CASE, TO THE EXTENT OTHERWISE EXPRESSLY PROVIDED), THE INFORMATION THAT IS THE SUBJECT MATTER
THEREOF IS WITHIN THE KNOWLEDGE OF THE RELEVANT PLEDGOR.

          “Revised Article 8 State” means one of the States of the United States in which UCC,
Revised Article 8, Investment Securities (with Conforming and Miscellaneous Amendments to Articles
1, 3, 4, 5, 9 and 10) 1994 Official Text has been adopted and is in effect.

          “Rights”, as applied to Collateral, means each Pledgor’s rights in that Collateral,
WHATEVER THE NATURE OF THOSE RIGHTS and, in any event, INCLUDING SUCH PLEDGOR’S POWER TO TRANSFER
RIGHTS IN SUCH COLLATERAL TO THE COLLATERAL AGENT.

          “Secured Obligations” means all advances to, and debts, liabilities, obligations,
covenants and duties of, any Pledgor arising under any Financing Document or otherwise with respect
to any Bonds, whether direct or indirect (including those acquired by assumption),

33

 

absolute or contingent, due or to become due, now existing or hereafter arising and including interest and fees
that accrue after the commencement by or against any Pledgor or any Affiliate thereof of any
proceeding under any Bankruptcy Laws naming such Person as the debtor in such proceeding,
regardless of whether such interest and fees are allowed claims in such proceeding.

          “Secured Parties” means all Persons that are, or at any time were, the Collateral
Agent, the Trustee, a Holder or any other Indemnified Party.

          “Securities Account” means (i) (A) each securities account listed on Schedule
4.19(a) and (B) each securities account, whether or not listed on Schedule 4.19(a),
under the control of the Collateral Agent, (ii) each securities account that is a successor to (A)
a securities account referred to in clause (i) or (B) a Securities Account which is such by virtue
of this clause (ii) and (iii) all cash, financial assets, instruments, documents, chattel paper,
general intangibles, accounts and other property from time to time credited to a Securities
Account.

          “Security” means (i)(A) each security listed on Schedule 4.19(a) and (B) each
security acquired by a Pledgor pursuant to its obligations under Section 4.19, (ii) each
security, whether or not listed on Schedule 4.19(a), of the same class or series and issued
by one of the same issuers as those listed on Schedule 4.19(a), in the possession of (A)
the Collateral Agent, or (B) a Person acting on behalf of the Collateral Agent or who has
acknowledged that it holds such security for the Collateral Agent, and (iii) each security, whether
or not listed on Schedule 4.19(a), of the same class or series and issued by one of the
same issuers as those listed on Schedule 4.19(a), delivered to or for the account of such
Pledgor by the Collateral Agent or any such Person for a purpose contemplated by Section 9-312(g)
of the UCC.

          “Security Agreement Questionnaire” means the Security Agreement Questionnaire in the
form attached hereto as Exhibit B executed and delivered by each Pledgor to the Collateral
Agent in connection with this Agreement.

          “Security Entitlement” means (i) (A) each security entitlement to a specified
financial asset credited to (1) securities account listed on Schedule 4.19(a) or (2) each
securities account (a “successor securities account”) that is a successor to (aa) a securities
account referred to in clause (1) or (bb) any other successor securities account (including one
that is such by virtue of this clause (2)), and (B) each security entitlement, whether or not so
credited, under the control of the Collateral Agent and (ii) all financial assets that are the
subject of each Securities Entitlement, including financial assets acquired by a Pledgor pursuant
to its obligations under Section 4.19 of the Agreement.

          “Security Interest” means the mortgages, pledges and assignments to the Collateral
Agent of, the continuing security interest of the Collateral Agent in, and the continuing lien of
the Collateral Agent upon, the Collateral intended to be effected by the terms of this Agreement or
any of the other Collateral Documents.

          “Trademarks” means (i) (A) all trademarks, trade names, corporate names, company
names, business names, fictitious business names, trade styles, service marks, logos and other
source or business identifiers, now existing or hereafter adopted or acquired, (B) the goodwill
associated therewith, (C) all registrations and recordings thereof, and (D) all

34

 

applications in connection therewith pending, at the time in question, in any Intellectual Property Recording
Office, including the Trademarks listed on Schedule 3.03 and (ii) all reissues, divisions,
continuations, continuations-in-part, extensions and renewals of each Trademark, including
Trademarks which are such by virtue of this clause (ii).

          “Trademark Licenses” means all Contracts naming any Pledgor as licensor or licensee
and granting any right to use any Trademark.

     Section 7.02 Other Interpretative Provisions.

     The interpretive provisions specified in Section 1.02 of the Indenture shall be
applicable to this Agreement. If any conflict or inconsistency exists between this Agreement and
the Indenture, the Indenture shall govern.

     Section 7.03 Representations and Warranties. All Representations and Warranties shall
be deemed made (a) in the case of any Representation and Warranty contained in this Agreement at
the time of its initial execution and delivery, at and as of the date hereof, (b) in the case of
any Representation and Warranty contained in this Agreement or any other document at the time any
Bonds are issued, at and as of such time and (c) in the case of any particular Representation and
Warranty, wherever contained, at such other time or times as such Representation and Warranty is
made or deemed made in accordance with the provisions of this Agreement or the document pursuant
to, under or in connection with which such Representation and Warranty is made or deemed made.

[Signature Pages Follow]

35

 

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed by
their duly authorized officers all as of the date first above written.

	 	 	 	 	 	 	 
	 	 	MOLECULAR INSIGHT	 	 
	 	 	PHARMACEUTICALS, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By	 	/s/ John E. McCray	 	 
	 

	 	 	 	 

	 	 
	 

	 	 	 	Name: John E. McCray

Title: COO	 	 

 

	 	 	 	 	 	 	 
	 	 	THE BANK OF NEW YORK TRUST	 	 
	 	 	COMPANY, N.A.,	 	 
	 	 	as Collateral Agent	 	 
	 
	 	 	 	 	 	 
	 
	 	By	 	/s/ Diana J. Kenneally	 	 
	 

	 		 	 
Name: Diana J. Kenneally	 	 
	 
	 		 	Title: VP

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