Document:

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                                                                   EXHIBIT 10.40
                                 PROMISSORY NOTE

                          __________12/18/03__________

                                     (DATE)

FOR VALUE RECEIVED, LA JOLLA PHARMACEUTICAL COMPANY a corporation located at the
address stated below ("MAKER") promises, jointly and severally if more than one,
to pay to the order of GENERAL ELECTRIC CAPITAL CORPORATION or any subsequent
holder hereof (each, a "PAYEE") at its office located at 401 MERRITT 7 SUITE 23,
NORWALK, CT 06851-1177 or at such other place as Payee or the holder hereof may
designate, the principal sum of EIGHTY THREE THOUSAND ONE HUNDRED FORTY THREE
AND 11/100 DOLLARS ($83,143.11), with interest on the unpaid principal balance,
from the date hereof through and including the dates of payment, at a fixed
interest rate of Eight and Twenty Seven Hundredths percent (8.27%) per annum, to
be paid in lawful money of the United States, in Forty-Two (42) consecutive
monthly installments of principal and interest as follows:

<TABLE>
<CAPTION>
  Periodic
 Installment        Amount
--------------   -----------
<S>              <C>
Thirty-Six (36)  $ 2,296.20
Five (5)         $ 2,095.98
</TABLE>

each ("Periodic Installment") and a final installment which shall be in the
amount of the total outstanding principal and interest. The first Periodic
Installment shall be due and payable on 1/1/04 and the following Periodic
Installments and the final installment shall be due and payable on the same day
of each succeeding month (each, a "Payment Date"). Such installments have been
calculated on the basis of a 360 day year of twelve 30-day months. Each payment
may, at the option of the Payee, be calculated and applied on an assumption that
such payment would be made on its due date.

The acceptance by Payee of any payment which is less than payment in full of all
amounts due and owing at such time shall not constitute a waiver of Payee's
right to receive payment in full at such time or at any prior or subsequent
time.

The Maker hereby expressly authorizes the Payee to insert the date value is
actually given in the blank space on the face hereof and on all related
documents pertaining hereto.

This Note may be secured by a security agreement, chattel mortgage, pledge
agreement or like instrument (each of which is hereinafter called a "SECURITY
AGREEMENT").

Time is of the essence hereof. If any installment or any other sum due under
this Note or any Security Agreement is not received within ten (10) days after
its due date, the Maker agrees to pay, in addition to the amount of each such
installment or other sum, a late payment charge of five percent (5%) of the
amount of said installment or other sum, but not exceeding any lawful maximum.
If (i) Maker fails to make payment of any amount due hereunder within ten (10)
days after the same becomes due and payable; or (ii) Maker is in default under,
or fails to perform under any term or condition contained in any Security
Agreement, then the entire principal sum remaining unpaid, together with all
accrued interest thereon and any other sum payable under this Note or any
Security Agreement, at the election of Payee, shall immediately become due and
payable, with interest thereon at the lesser of eighteen percent (18%) per annum
or the highest rate not prohibited by applicable law from the date of such
accelerated maturity until paid (both before and after any judgment).

Notwithstanding anything to the contrary contained herein or in the Security
Agreement, Maker may not prepay in full or in part any indebtedness hereunder
without the express written consent of Payee in its sole discretion.

<PAGE>

It is the intention of the parties hereto to comply with the applicable usury
laws; accordingly, it is agreed that, notwithstanding any provision to the
contrary in this Note or any Security Agreement, in no event shall this Note or
any Security Agreement require the payment or permit the collection of interest
in excess of the maximum amount permitted by applicable law. If any such excess
interest is contracted for, charged or received under this Note or any Security
Agreement, or if all of the principal balance shall be prepaid, so that under
any of such circumstances the amount of interest contracted for, charged or
received under this Note or any Security Agreement on the principal balance
shall exceed the maximum amount of interest permitted by applicable law, then in
such event (a) the provisions of this paragraph shall govern and control, (b)
neither Maker nor any other person or entity now or hereafter liable for the
payment hereof shall be obligated to pay the amount of such interest to the
extent that it is in excess of the maximum amount of interest permitted by
applicable law, (c) any such excess which may have been collected shall be
either applied as a credit against the then unpaid principal balance or refunded
to Maker, at the option of the Payee, and (d) the effective rate of interest
shall be automatically reduced to the maximum lawful contract rate allowed under
applicable law as now or hereafter construed by the courts having jurisdiction
thereof. It is further agreed that without limitation of the foregoing, all
calculations of the rate of interest contracted for, charged or received under
this Note or any Security Agreement which are made for the purpose of
determining whether such rate exceeds the maximum lawful contract rate, shall be
made, to the extent permitted by applicable law, by amortizing, prorating,
allocating and spreading in equal parts during the period of the full stated
term of the indebtedness evidenced hereby, all interest at any time contracted
for, charged or received from Maker or otherwise by Payee in connection with
such indebtedness; provided, however, that if any applicable state law is
amended or the law of the United States of America preempts any applicable state
law, so that it becomes lawful for the Payee to receive a greater interest per
annum rate than is presently allowed, the Maker agrees that, on the effective
date of such amendment or preemption, as the case may be, the lawful maximum
hereunder shall be increased to the maximum interest per annum rate allowed by
the amended state law or the law of the United States of America.

The Maker and all sureties, endorsers, guarantors or any others (each such
person, other than the Maker, an "OBLIGOR") who may at any time become liable
for the payment hereof jointly and severally consent hereby to any and all
extensions of time, renewals, waivers or modifications of, and all substitutions
or releases of, security or of any party primarily or secondarily liable on this
Note or any Security Agreement or any term and provision of either, which may be
made, granted or consented to by Payee, and agree that suit may be brought and
maintained against any one or more of them, at the election of Payee without
joinder of any other as a party thereto, and that Payee shall not be required
first to foreclose, proceed against, or exhaust any security hereof in order to
enforce payment of this Note. The Maker and each Obligor hereby waives
presentment, demand for payment, notice of nonpayment, protest, notice of
protest, notice of dishonor, and all other notices in connection herewith, as
well as filing of suit (if permitted by law) and diligence in collecting this
Note or enforcing any of the security hereof, and agrees to pay (if permitted by
law) all expenses incurred in collection, including Payee's actual attorneys'
fees. Maker and each Obligor agrees that fees not in excess of twenty percent
(20%) of the amount then due shall be deemed reasonable.

THE MAKER HEREBY UNCONDITIONALLY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM
OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF, DIRECTLY OR INDIRECTLY, THIS
NOTE, ANY OF THE RELATED DOCUMENTS, ANY DEALINGS BETWEEN MAKER AND PAYEE
RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS,
AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED BETWEEN MAKER AND PAYEE. THE
SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES
THAT MAY BE FILED IN ANY COURT (INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS,
TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY
CLAIMS.) THIS WAIVER IS IRREVOCABLE MEANING THAT IT MAY NOT BE MODIFIED EITHER
ORALLY OR IN WRITING, AND THE WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS,
RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS NOTE, ANY RELATED DOCUMENTS, OR
TO ANY OTHER DOCUMENTS OR AGREEMENTS

<PAGE>

RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. IN THE EVENT OF
LITIGATION, THIS NOTE MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.

This Note and any Security Agreement constitute the entire agreement of the
Maker and Payee with respect to the subject matter hereof and supercedes all
prior understandings, agreements and representations, express or implied.

No variation or modification of this Note, or any waiver of any of its
provisions or conditions, shall be valid unless in writing and signed by an
authorized representative of Maker and Payee. Any such waiver, consent,
modification or change shall be effective only in the specific instance and for
the specific purpose given.

Any provision in this Note or any Security Agreement which is in conflict with
any statute, law or applicable rule shall be deemed omitted, modified or altered
to conform thereto.

                                LA JOLLA PHARMACEUTICAL COMPANY

/s/ Lisa Peraza                 By: /s/ Gail A. Sloan
---------------------------     ---------------------------
(Witness)
Lisa Peraza                     Name: Gail A. Sloan
(Print name)
6455 Nancy  Ridge Drive         Title: Senior Director of Finance and Controller
San Diego, CA 92121
(Address)

                                Federal Tax ID #: 330361285

                                Address:   6455 Nancy Ridge Drive, San Diego,
                                San Diego County, CA 92121<PAGE>

                                                                   EXHIBIT 10.59

                            TAX INDEMNITY AGREEMENT

        This TAX INDEMNITY AGREEMENT, dated as of February 9, 2004 (this
"Agreement"), is entered into by and between Gary Lyons ("Indemnitor") and
Neurocrine Biosciences, Inc., a Delaware corporation ("Neurocrine").

                                    RECITALS

        WHEREAS, Indemnitor previously transferred options to purchase shares of
Neurocrine common stock granted under the Neurocrine Biosciences 1992 Incentive
Stock Plan (the "Options") to GEL, LLC, and in reliance on professional advice
received at the time of such exercise, Neurocrine has not withheld any sums, or
paid any amounts, for any federal, state, or local taxing authorities
(hereinafter collectively "Taxing Authorities") in connection with such
transfers or upon exercise of such Options by GEL, LLC;

        WHEREAS, Indemnitor and Neurocrine agree that it was implicit that
Indemnitor would bear responsibility for any adverse tax consequences suffered
by Neurocrine in connection with the transfer of the Options or the exercise of
the Options by GEL, LLC, and Indemnitor and Neurocrine are entering into this
Agreement to formalize Indemnitor's implicit promise to indemnify Neurocrine if
Neurocrine becomes obligated to pay taxes (other than Neurocrine's share of
employment taxes to the extent not greater than the amount Neurocrine would have
paid at the time had it treated the issuance and/or exercise of the Options as
taxable compensation), interest and/or penalties (including penalties on
Neurocrine's share of employment taxes) as a result of its not withholding sums
for, or paying any amounts to, any Taxing Authorities in connection with such
transfers and option exercises;

        WHEREAS, Neurocrine is agreeing not to take certain actions with respect
to employment taxes that it may otherwise have taken.

                                    AGREEMENT

        NOW, THEREFORE, in consideration of the foregoing recitals and the
covenants, promises and representations set forth in this Agreement, and for
other good and valuable consideration, the parties agree as follows:

1. Indemnitor Responsible for Taxes and Related Amounts. Indemnitor and
Neurocrine agree that Indemnitor is responsible for the payment of (a) all
income taxes, (b) the employee's share of Social Security and Medicare taxes
under the Federal Insurance Contributions Act ("FICA"), (c) any penalties
assessed against Neurocrine by reason of nonpayment of unemployment taxes under
the Federal Unemployment Tax Act ("FUTA"), and (d) the employee's share of all
employment taxes and withholdings under applicable state laws (including state
disability insurance) that have been incurred or may ever be incurred in each of
(a) through (c) above in so far as such amount are payable respect to the
transfer or the exercise

<PAGE>

of the Options, as well as for certain interest, penalties, and other amounts as
defined in Section 2, below that are related to such taxes.

        2. Indemnity. Indemnitor agrees to indemnify and reimburse Neurocrine
and hold it harmless from (a) taxes, interest and penalties, that Neurocrine may
be required to pay, or in fact pays in accordance with Section 4 below, any
Taxing Authority because Neurocrine has not withheld and paid to the Taxing
Authorities personal income taxes of the Indemnitor or Indemnitor's share of
FICA taxes or (b) interest and penalties that Neurocrine or its subsidiaries may
be required to pay by reason of Neurocrine's nonpayment of FUTA taxes with
respect to the transfer of the Options by Indemnitor to GEL, LLC, and/or the
exercise of the Options by GEL, LLC, or any other transferee; and (c) any
interest, penalties, other additions to tax, or other charges that Neurocrine,
or its subsidiaries may be required to pay, or in fact pays in accordance with
Section 4 below, to any Taxing Authorities because Neurocrine has not paid to
the Taxing Authorities the employer's share of FICA taxes or unemployment taxes
under the Federal Unemployment Tax Act (other than the FUTA tax otherwise
payable by Neurocrine) with respect to the transfer of the Options by Indemnitor
to GEL, LLC, and/or the exercise of the Options by GEL, LLC, or any other
transferee. Subject to Section 4 below, Indemnitor shall immediately pay to
Neurocrine, upon its request, any amounts Indemnitor is required to pay
Neurocrine pursuant to this Section 2. Indemnitor's obligation to indemnify
shall exist regardless of whether Neurocrine is required to pay the
aforementioned taxes, penalties or interest because a Taxing Authority contends
that Neurocrine was legally required to withhold or pay such amounts or whether
Neurocrine is required to pay such taxes, interest or penalties because of
Indemnitor's non-payment or underpayment of such taxes, interest or penalties.

        3. Indemnitor to Provide Notice of Tax Directive. If any Taxing
Authority notifies Indemnitor that it has reached a conclusion regarding the
appropriate tax treatment of the transfer of Options to GEL, LLC, or exercise of
Options by GEL, LLC, and indicates as part of such notice that Neurocrine was
required to withhold any sums for, or pay any amounts to, such Taxing Authority
in connection with any such transfer or exercise, Indemnitor shall promptly
advise Neurocrine of such notice and provide to Neurocrine copies of any written
correspondence relating to Neurocrine's obligations.

        4. Neurocrine's Obligations.

        (a) Neurocrine agrees that, prior to a determination by any court of
competent jurisdiction that Neurocrine should have withheld and/or paid any of
the taxes, interest, or penalties described in Sections 1 and 2 above, it will
not (except as otherwise contemplated by this Agreement) withhold any sums for,
or pay any amounts to, any Taxing Authority or otherwise demand payment from
Indemnitor for any amounts payable by such Indemnitor pursuant to Section 2
above unless Indemnitor requests that Neurocrine withhold or pay such amounts,
or consents to Neurocrine's taking such action; provided, however, that
Neurocrine may withhold and/or pay any such amounts to any Taxing Authority that
claims such payments are owed unless Indemnitor pays Neurocrine's out-of-pocket
costs and expenses, including reasonable attorneys' fees, incurred in connection
with contesting any such claim, to the extent provided in Section 4(b) below. In
this regard, Indemnitor shall not be responsible for

                                       2
<PAGE>

reimbursing any out-of-pocket costs or expenses of Neurocrine if Neurocrine
determines, pursuant to the fifth sentence of this Section 4, to make a payment
to a Taxing Authority rather than oppose such claim. (If Neurocrine initially
opposes such a claim by a Taxing Authority but then decides to make a payment,
Indemnitor shall be responsible for Neurocrine's out-of-pocket costs and
expenses incurred in connection with the opposition, but not after a
determination has been made to make the payment.) Indemnitor agrees to pay any
amounts that are subject to this Agreement immediately upon the earlier of (i) a
determination by any court that Neurocrine should have withheld and/or paid any
of the taxes, interest, or penalties subject to Section 2, (ii) Indemnitor's
requesting that Neurocrine withhold or pay such amounts or Indemnitor's
consenting to Neurocrine's taking such action, and (iii) as requested by
Neurocrine pursuant to the following sentence. Notwithstanding anything herein
to the contrary, the parties understand and agree that (a) at no time will
Neurocrine be required to advance any sums to, or extend any credit on behalf
of, Indemnitor, and (b) to the extent that (1) an actual demand for payment has
been made to Neurocrine by a Taxing Authority, (2) a decision to withhold or
otherwise make payment to such Taxing Authority on behalf of Neurocrine has been
made by the Board of Directors of Neurocrine based on its determination of the
best interests of the stockholders of Neurocrine; and (3) prior to making such a
decision, there has been notice to the Indemnitor and an opportunity for
Indemnitor and his or her counsel to make a presentation to the Board regarding
such matters, Neurocrine shall have the right to immediately demand payment from
the Indemnitor, and the Indemnitor shall have the obligation to immediately pay
the amount so demanded (and upon receipt by Neurocrine that portion of such
amounts representing taxes, interest and penalties shall be remitted to such
Taxing Authority), and further, Neurocrine also shall have the right, but not
the obligation, to pay any amounts demanded by any Taxing Authority directly and
to obtain immediate reimbursement from the Indemnitor, plus interest.

        (b) This Agreement is one of several Tax Indemnity Agreements in similar
form entered into between Neurocrine and employees of Neurocrine arising from
similar transactions. Indemnitor shall be responsible for only his or her pro
rata share of the out-of-pocket costs and expenses reimburseable under Section
4(a), which initially is deemed to be 48.32%. Such percentage limitation shall
not apply to amounts payable by Neurocrine to Taxing Authorities and otherwise
due by Indemnitor under this Agreement. In the event one or more of the other
individuals who signed Tax Indemnity Agreements in similar form is no longer
contesting claims made by Taxing Authorities, but Neurocrine continues to
contest claims made by Taxing Authorities at the request of Indemnitor,
Indemnitor's share of Neurocrine's out-of-pocket costs and expenses shall be
increased to his or her then-current pro rata share as among all such
individuals who continue to contest such claims.

        5. Security for Indemnitor's Obligations. In the event Indemnitor's
employment with Neurocrine shall terminate, at Neurocrine's request, Indemnitor
and Neurocrine will enter into a mutually acceptable arrangement for security of
Indemnitor's obligations hereunder in an amount sufficient to cover Indemnitor's
reasonable potential liability under this Agreement.

        6. Miscellaneous.

                                       3
<PAGE>

               (a) Modification and Amendment. This Agreement may not be
altered, amended, modified, or otherwise changed in any way except by a written
instrument signed by each party.

               (b) Headings. The headings and titles of the provisions of this
Agreement are inserted for convenience only and shall not affect the
construction or interpretation of any provision.

               (c) Cumulative Remedies. The right of any party to be indemnified
pursuant to this Agreement shall be cumulative and in addition to every other
right, power or remedy available to such party, whether available at law, in
equity or otherwise. Indemnitor's obligations hereunder may not be reduced by
set-off.

               (d) Governing Law; Arbitration; Waiver of Jury Trial.

                        (i) This Agreement shall be governed and construed in
                accordance with the laws of the State of California, without
                regard to the laws that might be applicable under conflicts of
                laws principles.

                        (ii) All disputes, controversies or claims between
                Indemnitor and Neurocrine arising, directly or indirectly, out
                of or relating to this Agreement shall be resolved by final,
                binding arbitration conducted by a single arbitrator in
                accordance with the Rules of the American Arbitration
                Association as then in effect, except as provided herein. Unless
                the parties otherwise agree, any arbitration shall be held in
                San Diego County, California. The parties shall be entitled to
                discovery sufficient to adequately arbitrate the claims and
                defenses, including access to essential documents and witnesses,
                as determined by the arbitrator. Costs and fees of the
                arbitrator shall be borne by the non-prevailing party. The award
                of the arbitrator, which may include equitable relief, shall be
                final and not subject to appeal, and judgment may be entered
                upon it in accordance with the applicable law in any court
                having jurisdiction thereof. Any demand for arbitration shall be
                in writing and must be made within a reasonable time after the
                claim, dispute or other matter in question has arisen. In no
                event shall the demand for arbitration be made after the date
                that institution of legal or equitable proceedings based upon
                such claim dispute or other matter would be barred by the
                applicable statue of limitations. In no event shall this clause
                (ii) of Section 6(d) be deemed to preclude a party hereto from
                instituting legal action seeking relief in the nature of a
                restraining order, an injunction or the like in order to protect
                his, her or its rights pending the outcome of an arbitration
                hereunder and, if any party hereto shall resort to legal action
                for such types of relief pending the outcome of any such
                arbitration proceeding or prior to the initiation thereof, such
                party shall not be deemed to have waived its rights to cause
                such matter or any other matter to be referred to arbitration
                pursuant to this Section 6(d).

                                       4
<PAGE>

                        (iii) EACH PARTY IRREVOCABLY WAIVES ITS RIGHTS TO A JURY
                TRIAL OF ANY DISPUTE, CLAIM OR CAUSE OF ACTION RELATED TO OR
                ARISING OUT OF THIS AGREEMENT. THE SCOPE OF THIS WAIVER IS
                INTENDED TO INCLUDE ANY AND ALL DISPUTES, CLAIMS OR CAUSES OF
                ACTION, INCLUDING WITHOUT LIMITATION, CONTRACT CLAIMS, TORT
                CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND
                STATUTORY CLAIMS. EACH SUCH PARTY FURTHER WARRANTS AND
                REPRESENTS THAT IT HAS HAD THE OPPORTUNITY TO HAVE LEGAL COUNSEL
                REVIEW THIS WAIVER.

               (e) Severability. If any provision of this Agreement is found or
held to be invalid or unenforceable by any tribunal of competent jurisdiction,
then the meaning of such provision will be construed, to the extent feasible, so
as to render the provision enforceable, and if no feasible interpretation would
save such provision, it will be severed from the remainder of this Agreement.
The remainder of this Agreement will remain in full force and effect.

               (f) Counterparts. To facilitate execution, this Agreement may be
executed in as many counterparts as may be required. It shall not be necessary
that the signatures on behalf of all parties appear on each counterpart of this
Agreement. All counterparts of this Agreement shall collectively constitute a
single agreement. Signatures to this Agreement may be transmitted by facsimile
and such signatures shall be deemed to be originals.

               (g) Assignment. The Indemnitor may not assign this Agreement
without the prior written consent of the other parties, and any such prohibited
assignment shall be void. Subject to the foregoing, this Agreement shall be
binding upon and inure to the benefit of the respective legal representatives,
successors, assigns, heirs, and devisees of the parties.

               (h) Legal Fees. If any party to this Agreement brings an action
in arbitration or a court of competent jurisdiction to enforce its rights under
this Agreement, the prevailing party shall be entitled to recover its costs and
expenses, including without limitation reasonable attorneys' fees, incurred in
connection with such action.

               (i) Time is of the Essence. Time is of the essence with respect
to every provision of this Agreement.

               (j) Construction. The parties have participated jointly in the
negotiation and drafting of this Agreement. In the event an ambiguity or
question of intent or interpretation arises, this Agreement shall be construed
as if drafted jointly by all parties and no presumption or burden of proof shall
arise favoring or disfavoring any party by virtue of the authorship of any of
the provisions of this Agreement. The use of the word "including" shall not be
deemed to be limited and shall be read as "including but not limited to." The
fundamental premise of this Agreement is that in all events Neurocrine shall
incur no obligation or expense in connection with the items identified in
Section 2, above, and further that this Agreement shall be interpreted
consistently with that intent.

                                       5
<PAGE>

               (k) Entire Agreement; No Inconsistent Agreements. This Agreement,
together with any exhibits hereto, contains the entire agreement between the
parties and supersedes any prior written or oral agreement between said parties
concerning the subject matter contained herein. There are no representations,
agreements, arrangements or understandings, oral or written, between or among
the parties relating to the subject matter contained in this Agreement, which
are not fully expressed herein. The parties also agree that Indemnitor's
obligations and responsibilities under this Agreement shall not be limited or
subject to indemnity or insurance by Neurocrine through any other agreement or
policy relating to the Indemnitor, including any general indemnity agreements or
any insurance policy Neurocrine may have.

               (l) Further Assurances. Each party hereby agrees to promptly sign
any additional instruments or documents which are necessary or appropriate to
carry out the purpose of this Agreement.

                            {Signature Page Follows}

                                       6
<PAGE>

        The parties have entered into this Agreement as of the date first set
forth above.

                                      NEUROCRINE BIOSCIENCES, INC.

                                      By: /s/ Margaret Valeur-Jensen
                                          --------------------------------------
                                      Name:
                                      Its:

                                      Address:
                                      10555 Science Center Drive
                                      San Diego, California 92121
                                      Telephone: (858) 658-7600
                                      Fax:

                                      /s/ Gary Lyons
                                      ------------------------------------------
                                      GARY LYONS

                                      Address:

                                      Telephone:
                                      Fax:

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