Document:

Third Amendment dated May 31, 2008 to Lease Agreement.

 Exhibit 10.63 
 THIRD AMENDMENT TO LEASE 
 THIS THIRD AMENDMENT TO LEASE (this “Third Amendment”) is
made as of October 24, 2008, by and between ARE-SAN FRANCISCO NO. 12, LLC, a Delaware limited liability company (“Landlord”), and EXELIXIS, INC., a Delaware corporation (“Tenant”). 
 RECITALS 
 A. Landlord and
Tenant entered into that certain Lease Agreement dated as of September 14, 2007, as amended by that certain First Amendment to Lease dated May 31, 2008, and as further amended by that certain Second Amendment to Lease dated
October 23, 2008 (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain Premises in a building located at 249 East Grand Avenue, South San Francisco, California. The Premises are more particularly described in
the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 
 B.
Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease to extend the date by which Tenant is required to elect to exercise the Expansion Right for the Expansion Space from December 31, 2008,
until December 31, 2009.  
 NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by
this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
  

	1.	Expansion of the Premises. Notwithstanding anything to the contrary contained in the Lease, all references in Sections 39(a) and (b) of the Lease to
December 31, 2008, are hereby deleted and the date of December 31, 2009, is inserted in its place. 

  

	2.	Miscellaneous. 

 a. This Third Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This Third Amendment may be
amended only by an agreement in writing, signed by the parties hereto. 
 b. This Third Amendment is binding upon and shall inure to
the benefit of the parties hereto, their respective agents, employees, representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 
 c. This Third Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken
together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart
identical thereto except having additional signature pages executed by other parties to this Third Amendment attached thereto. 
 d.
Except as amended and/or modified by this Third Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this Third Amendment. In the event of any
conflict between the provisions of this Third Amendment and the provisions of the Lease, the provisions of this Third Amendment shall prevail. Whether or not specifically amended by this Third Amendment, all of the terms and provisions of the Lease
are hereby amended to the extent necessary to give effect to the purpose and intent of this Third Amendment. 
 [Signatures are on the next
page.] 
  

 1 

 IN WITNESS WHEREOF, the parties hereto have executed this Third Amendment as of the day and year
first above written. 
  

													
	LANDLORD:	 		 	ARE-SAN FRANCISCO NO. 12, LLC,
		 		 	a Delaware limited liability company.
					
		 		 		 	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P.,
 a
Delaware limited partnership, managing member

						
		 		 		 		 	By:	 	ARE-QRS CORP.,
		 		 		 		 		 	a Maryland Corporation, general partner
							
		 		 		 		 		 	By:	 	/s/ Eric S. Johnson
		 		 		 		 		 	Its:	 	Assistant Vice President Real Estate Legal Affairs
			
	TENANT:	 		 	 EXELIXIS, INC.,
 a Delaware
corporation

					
		 		 		 	By:	 	/s/ Frank Karbe
		 		 		 	Its:	 	Executive Vice President and Chief Financial Officer

  

 2Second Amendment to the Contract Research Agreement.

 EXHIBIT 10.64 
 [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities
Exchange Act of 1934, as amended. 
 SECOND AMENDMENT TO THE 
 CONTRACT RESEARCH AGREEMENT 
 This SECOND AMENDMENT TO THE CONTRACT RESEARCH
AGREEMENT (the “Amendment”) is made and entered into by and between AGRIGENETICS, INC., a Delaware corporation having its principal place of business at 9330
Zionsville Road, Indianapolis, Indiana 46268 (“Agrigenetics”) and EXELIXIS PLANT SCIENCES, INC., a Delaware corporation having its principal place of business at
16160 SW Upper Boones Ferry Road, Portland, Oregon 97224 (“EPS”). Agrigenetics and EPS are sometimes referred to herein individually as a “Party” and collectively as the “Parties”. 
 RECITALS 
 A.
Agrigenetics, Mycogen Corporation, EPS and Exelixis, Inc. (“Exelixis”) are parties to a Contract Research Agreement effective as of September 4, 2007 as amended by the First Amendment effective as of January 1, 2008
(the “Agreement”), under which Agrigenetics engaged EPS to conduct certain research pursuant to a Research Plan. 
 B.
Agrigenetics and EPS desire to amend the Agreement in accordance with Section 14.10 of the Agreement to expand the Research Budget to include funding by Agrigenetics for [ * ]. 
 NOW, THEREFORE, the Parties agree as follows: 
  

	1.	SECOND AMENDMENT OF THE AGREEMENT 

 The parties hereby agree to amend the terms of the Agreement as provided below, retroactively effective as of October 27, 2008 (the “Second
Amendment Effective Date”). Where the Agreement is not explicitly amended, the terms of the Agreement will remain in force. Capitalized terms used in this Amendment that are not otherwise defined herein shall have the same meanings as such
terms are given in the Agreement. 

	 	1.1	Section 8.8 is added to the Agreement to read in its entirety as follows: 

 “8.8 [ * ]: 
 Pursuant to the SECOND AMENDMENT TO THE CONTRACT RESEARCH AGREEMENT EFFECTIVE AS OF
OCTOBER 27, 2008 (the “Second Amendment”), EPS agrees to [ * ]. The attached Exhibit 2A provides a description of the [ * ]. The Parties hereby agree that [ * ]. As such, the rights and obligations of the
Parties that pertain to Key Personnel, including without limitation the rights and obligations set forth in Article 8 of the CRA, shall apply to such individuals. While Agrigenetics desires EPS to [ * ], EPS may hire people for such positions in its
discretion based on program needs as long as [ * ] as is specified below in Section 6.2(a), as amended by the Second Amendment.” 
  

	 	1.2	Section 6.2(a)(i)(2) is amended by adding the following sentence: 

 “On or before [ * ], Agrigenetics shall pay EPS [ * ] for the [ * ];” 
 Section 6.2(a)(i)(3) is replaced in its entirety with the following: 
 “(3) the Estimated Annual FTE Payment for the third Contract Year shall be [ * ] for the approximately [ * ] FTEs engaged in
the Research Program;” 
 Section 6.2(a)(i)(4) is replaced in its entirety with the following: 
 “(4) the Estimated Annual FTE Payment for the forth Contract Year shall be [ * ] for the approximately [ * ] FTEs engaged in
the Research Program; and” 
 Section 6.2(a)(i)(5) is replaced in its entirety with the following: 
 “(5) the Estimated Annual FTE Payment for the fifth Contract Year shall be [ * ] for the approximately [ * ] FTEs engaged in
the Research Program.” 
  

	2.	MISCELLANEOUS 

  

	 	2.1	Full Force and Effect. This Amendment amends the terms of the Agreement and is deemed incorporated into the Agreement. The provisions of the Agreement, as amended by this
Amendment, remain in full force and effect. 

  

	 	2.2	Entire Agreement. The Transactional Agreements, including the Agreement as amended by this Amendment, set forth the entire understanding of the parties hereto relating to the
subject matter thereof and supersede all prior agreements and understandings among or between any of the parties hereto relating to the subject matter thereof. 

  

 [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed
separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

	 	2.3	Counterparts. This Amendment may be executed in two (2) counterparts, each of which shall constitute an original and both of which, when taken together, shall constitute
one agreement. The exchange of a fully executed Amendment (in counterparts or otherwise) by electronic transmission, including by email, or facsimile shall be sufficient to bind the Parties to the terms and conditions of this Amendment.

 IN WITNESS WHEREOF, Agrigenetics and EPS have executed
this Amendment by their respective duly authorized representatives as of the Amendment Effective Date. 
  

									
	AGRIGENETICS, INC.	 		 	EXELIXIS PLANT SCIENCES, INC.
					
	By:	 	/s/ William A. Kleschick, Ph.D.	 		 	By:	 	/s/ George Scangos
		 	William A. Kleschick, Ph.D.	 		 	Name:	 	George Scangos
		 	Global Leader, Discovery Research	 		 	Title:	 	President and Chief Executive Officer

  

 [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed
separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

 Exhibit 2A 
 [ * ] 
  

 [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed
separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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