Document:

<PAGE>

                                                                    Exhibit 10.5

                                    CONTRACT

                                     between

                     Bruker - Analytical X-Ray Systems GmbH

                         Ostliche Rheinbruckestrasse 50
                                 76187 Karlsruhe
                                     GERMANY

                                    - "AXS" -

                                       and

                     GKSS Forschungszentrum Geesthacht GmbH
                         Institut fur Werkstoffforschung
                               Max-Planck-Strasse
                                21502 Geesthacht

                                   - "GKSS" -

                              GKSS No. P3.3.02.F.02

                                    regarding

               the Purchase of Gradient Multi-layer X-ray Mirrors

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS
EXHIBIT, WHICH PORTIONS HAVE BEEN OMITTED AND REPLACED WITH [**] AND FILED
SEPARATELY WITH THE COMMISSION.

<PAGE>

1.       CONTRACT PRODUCTS

         "Contract products" are the X-ray mirrors defined in APPENDIX 1 to this
         Contract.

         GKSS agrees not to sell contract products to third parties. AXS agrees
         to make contract products available to the market at unfair [SIC]
         conditions.

2.       ORDERS

2.1      GKSS shall supply AXS on the basis of individual purchase orders
         ("orders") according to the conditions of this Contract.

2.2      Each order shall list the necessary information, such as item delivered
         (type of mirror, parameters, and quantity), delivery date, and contract
         number. GKSS shall immediately confirm each order in writing.

2.3      Unless otherwise expressly agreed in this Contract or in the respective
         order, the AXS terms and conditions of orders Appendixed to this
         Contract as APPENDIX 2 shall apply to orders. General GKSS terms and
         conditions of business that differ from the aforementioned terms and
         conditions shall not apply.

2.4      The prices established in APPENDIX 3 of this Contract shall be used as
         a basis for calculating charges; these are fixed prices until September
         30, 1999. Changes in price shall be made by mutual agreement and
         specified in writing. GKSS is prepared to renegotiate the prices in the
         event of an increase in the ordered quantity or a reduction of the
         market price.

2.5      Delivery shall be ex works, including packaging. GKSS shall ensure that
         the contract products are packed with consideration of all normal
         transportation risks.

2.6      Payment shall be made within 30 (thirty) days after delivery and upon
         receipt and verification of the invoice.

2.7      The delivery time for orders less than or equal to 15 units shall be 6
         (six) weeks, beginning with receipt of the commercially and technically
         cleared order by GKSS and confirmation of the order by GKSS. GKSS shall
         confirm the commercially and technically cleared order within two (2)
         weeks. The delivery period for subsequent orders shall be six (6) weeks
         after the delivery of each previous order.

3.       REQUIREMENTS FORECAST

         AXS shall first determine its projected needs for the contract products
         over a period of 12 (twelve) months, beginning on the effective date of
         this Contract.

<PAGE>

         This requirements forecast shall be adjusted and updated quarterly for
         each subsequent 12 (twelve) month period (revolving requirements
         forecast). The requirements forecast is intended to ensure the fewest
         interruptions in product deliveries to AXS and shall have no binding
         effect.

4.       RIGHT TO EMERGENCY PRODUCTION

4.1      GKSS recognizes that the continuous availability of the contract
         products is of the utmost importance to AXS. To ensure the continuous
         availability of the contract products for AXS, GKSS and AXS agree upon
         a right to emergency production as stipulated in Item 4.2 below.

4.2      If and to the extent that GKSS for any reason ceases production of the
         contract products or fails to fulfill its delivery obligations for a
         period of more than one (1) month, AXS may demand that GKSS enable AKS
         (particularly through the immediate provision by GKSS of technical
         information and documents, including software, needed for the
         production and testing of the contract products) to manufacture the
         contract products itself or to have contract products manufactured and
         distributed for it, and that GKSS grant the necessary rights (including
         relevant patent rights of GKSS).

         If the right to emergency production is exercised, then GKSS shall be
         entitled to an appropriate licensing fee for the use of its technical
         information and documents/software-programs and/or patent rights.

         In the event that it exercises its right to emergency production, AXS
         may require that GKSS make available at appropriate terms and
         conditions any special tools and/or equipment that would otherwise be
         unobtainable. If GKSS is unable to comply with this requirement, then
         it shall enable AXS to construct copies these special tools and/or
         equipment to the extent possible.

4.3      The right to emergency production shall end as soon as the circumstance
         requiring the right to emergency production has been permanently
         rectified. If a third party is used during emergency production, then
         this third party shall be required to enter into a confidentiality
         agreement.

         In the event of delay or inability to comply, any existing legal claims
         that exceed the terms of Item 4 shall remain unaffected thereby.

5.       WARRANTY AND LIABILITY

5.1      GKSS warrants that the contract products correspond to the
         specifications as defined in APPENDIX 1.

         The warranty period shall be 12 (twelve) months, beginning with
         acceptance of the contract products by AXS. The contract products must
         be accepted no later

<PAGE>

         than eight (8) weeks after delivery by GKSS. If acceptance is not
         expressly refused within this period, then the contract products shall
         be considered as accepted.

         Complaints regarding defects must be promptly communicated to GKSS in
         writing. GKSS shall have the right to choose whether to repair the
         defect or to replace the defective contract product with a
         non-defective contract product within 20 (twenty) working days after
         the defective contract products have been received by GKSS. If the
         defects are not remedied, AXS shall have the right to demand at its
         discretion either a reduction of the price or cancellation of the
         Contract for the delivery about which a complaint has been made. Any
         further warranty claims shall be precluded in this case.

         The warranty period shall be three (3) months for any repaired or
         replaced contract products delivered, although it shall continue at
         least until the expiration of the original warranty period.

5.2      Liability of GKSS, its legal representatives, and its agents due to
         breach of contract or tort shall be limited to willful misconduct,
         gross negligence, lack of a guaranteed quality, and violation of an
         obligation if such violation would endanger the object of the Contract.
         Liability shall be limited to DM 500,000 (five hundred thousand
         Deutsche marks).

5.3      AXS shall indemnify GKSS against all product liability claims made by
         third parties due to faulty contract products.

6.       PROTECTION OF INDUSTRIAL PROPERTY RIGHTS

         If a third party exercises legitimate claims against AXS based upon or
         related to patent rights due to the method of manufacturing the
         contract products, then GKSS shall be obligated to choose between the
         following actions, to be performed at its own expense:

         - to obtain a right of use for AXS from the owner of the patent rights,
           or

         - to change the parts of the contract products relevant to the patent
           rights, or

         - to replace the parts relevant to the patent rights with parts not
           subject to the patent rights, or

         - to take back the corresponding contract products in exchange for a
           refund of the purchase price.

         A prerequisite for this is that AXS must immediately advise GKSS of
         all claims made, as well as all subsequent proceedings.

<PAGE>

         Any further claims resulting from infringement of patent rights owned
         by third parties shall be precluded.

7.       CONFIDENTIALITY

         Each contracting party shall maintain confidentiality regarding
         technical documents and information, as well as special knowledge of
         each other's internal matters, and shall divulge such information to
         third parties only with the explicit consent of the other contracting
         party, if and to the extent that this information is not generally
         known through publication or some other form without breaching this
         obligation of confidentiality.

         Any third parties that may become involved in this Contract must also
         be explicitly subjected to this obligation. This obligation shall
         continue in effect even after termination of this Contract.

8.       CONTRACTUAL PERIOD

         This Contract shall come into effect upon signing.
         AXS shall be obligated to purchase mirrors in a cumulative total volume
         of DM 360,000 during the period of October 1, 1998 to September 30,
         2001. The Contract may be terminated no earlier than September 30, 2000
         with a 12-month period of notice. In the event of this premature
         termination, AXS shall be obligated to purchase mirrors valued at no
         less then DM 240,000.

9.       OTHER PROVISIONS

9.1      No ancillary agreements exist. Changes and additions to this Contract
         must be made in writing.

9.2      Should individual provisions of this Contract be or become invalid,
         then the remaining provisions of this Agreement shall be unaffected
         thereby. In such an event, both sides shall replace the invalid
         provision with a valid provision that achieves the purpose of the
         affected provision to the extent possible. A similar procedure must be
         applied should a loophole become apparent in the course of completing
         the Contract.

9.3      Two (2) copies of the Contract shall be prepared, with each contracting
         party receiving one copy.

Geesthacht, October 1, 1998                  Karlsruhe, October 1, 1998
GKSS Forschungszentrum                       Bruker-AXS-Analytical X-Ray Systems
Geesthacht GmbH                              GmbH

---------------------------                  -----------------------------------

<PAGE>

Appendix 1
                                 Specifications

<TABLE>
<CAPTION>
<S>                             <C>                <C>         <C>         <C>        <C>          <C>         <C>             <C>
-----------------------------------------------------------------------------------------------------------------------------------
C79298A3208C30                  Sl-Cu-S-40-P       [**]        [**]        [**]       [**]         [**]        [**]           [**]
-----------------------------------------------------------------------------------------------------------------------------------
C79298A208C31                   Sl-Cu-S-60-P       [**]        [**]        [**]       [**]         [**]        [**]           [**]
-----------------------------------------------------------------------------------------------------------------------------------
C79298A3208C32                  Sl-Cu-L-60-P       [**]        [**]        [**]       [**]         [**]        [**]           [**]
-----------------------------------------------------------------------------------------------------------------------------------
C79298A3208C33                  Sl-Co-S-40-P       [**]        [**]        [**]       [**]         [**]        [**]           [**]
-----------------------------------------------------------------------------------------------------------------------------------
C79298A3208C34                  Sl-Co-S-60-P       [**]        [**]        [**]       [**]         [**]        [**]           [**]
-----------------------------------------------------------------------------------------------------------------------------------
C79298A3208C35                  Sl-Co-L-60-P       [**]        [**]        [**]       [**]         [**]        [**]           [**]
-----------------------------------------------------------------------------------------------------------------------------------
Custom design according to
specifications to be determined
-----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

Dimensional tolerances:          [**]
Error of curvature:              [**]
Substrate material:              [**]
Material combination:            [**]
Coating material:                [**]

The procedure for determining the radioscopic mirror parameters is as follows:
(A) Measurements:
    On the [**] mirror, [**] measurements are performed [**] gradient using
    [**]. [**] measurements are made at [**] along the gradient. [**], the
    measurement points should lie [**] from each other, and [**], they should
    be at a distance of [**]. The [**] area to be measured should be chosen in
    such a way that the [**] can still be [**].
(B) Determination of mean reflectivity:
    The mean reflectivity is calculated from the measured [**] to the
    intensity [**].
(C) Determination of the mean lattice constant:
    The lattice constant is calculated by [**] measurements and [**].
(D) Determination of the mean gradient:
    The mean gradient is determined from the mean lattice constants [**].

[**] Indicates that information has been omitted and filed separately with the
Commission pursuant to a request for confidential treatment.

<PAGE>

APPENDIX 2

                             CONDITIONS OF PURCHASE

I. PURCHASE ORDER AND ORDER CONFIRMATION
(1) Bruker AXS Analytical X-Ray Systems GmbH (purchaser) may cancel the purchase
order if the supplier has not provided written confirmation (order confirmation)
within two weeks after receipt.
(2) If the order confirmation differs from the purchase order, the purchaser
shall be bound only if he has agreed to the difference in writing. Specifically,
the purchaser shall be bound by the supplier's general terms and conditions of
business only to the extent that these terms and conditions are in accordance
with the purchaser's terms and conditions, or if the purchaser agrees to them in
writing. Acceptance of product deliveries or services, as well as payments, do
not constitute an agreement.
(3) Changes or additions to the purchase order shall be valid only if they are
confirmed in writing by the purchaser.

II. DELIVERY TIME
(1) Timeliness of product deliveries shall be determined based upon their
arrival at the receiving location specified by the purchaser, and the timeliness
of product deliveries involving assembly or installation, as well as services,
shall be based upon their acceptance.
(2) In the event of a discernible delay of a product delivery or service, the
purchaser must be notified of this delay immediately and his decision regarding
further action must be obtained.

III. TRANSFER OF RISK, SHIPPING
(1) For services and product deliveries involving assembly or installation, risk
shall be transferred upon acceptance; for product deliveries without setup or
assembly, risk shall be transferred upon their arrival at the receiving location
specified by the purchaser.
(2) Unless otherwise agreed, the supplier shall bear the costs for shipping and
packaging. In the case of pricing ex works or from the supplier's sales
warehouse, shipments must be made at the lowest possible cost in each case,
unless the purchaser has specified a particular mode of shipment. The supplier
shall bear additional costs incurred due to a failure to comply with shipping
regulations. The purchaser may also specify the mode of shipment for pricing
free consignee. The supplier shall bear the additional costs of any accelerated
shipment needed in order to comply with his delivery deadline.
(3) Each delivery shall be accompanied by a packing slip or delivery receipt
containing details of the contents as well as the complete purchase order
identification code. An immediate notification of the shipment must be sent with
this same information.

IV. INVOICES

Invoices must specify the purchase order identification code as well as the
numbers for each individual item. Invoices are not payable so long as this
information is missing. Copies of invoices must be identified as duplicates.

<PAGE>

V. PAYMENTS

(1) Unless otherwise agreed, payments shall be made
within 14 days minus a 3% discount, or within 30 days minus a 2% discount, or
within 90 days net.
(2) The payment period shall begin as soon as the product delivery or service
has been completed and the properly issued invoice has been received. If the
supplier must provide material tests, inspection logs, quality documents, or
other documents, the receipt of these documents shall also be a prerequisite for
the completeness of the product delivery or service. A discount deduction shall
also be permitted if the purchaser offsets or withholds payments in an
appropriate amount due to defects; the payment period shall begin following
complete remedy of the defect or defects.
(3) Payments do not constitute recognition of the products or services as
complying with the Contract.

VI. LIABILITY FOR DEFECTS

(1) The supplier must provide a one-year warranty for his products and services.
The warranty period shall begin with the transfer of risk (Item III, Para. 1).
In the event of product deliveries to locations where the purchaser is
conducting projects outside of his factories or facilities, the warranty period
shall begin with the acceptance by the party for whom the purchaser is
conducting the project or projects. The warranty period shall end no later than
two years following transfer of risk.
(2) If defects are determined before or upon transfer of risk or appear during
the warranty period, then the supplier must bear the costs for either
eliminating the defect or delivering a new non-defective product or service,
based upon the purchaser's choice. This shall also apply to product deliveries
in which inspection is limited to random samples. The purchaser shall make a
decision based upon his own reasonable discretion.
(3) If the supplier fails to remedy the defect or provide a new product delivery
or service within an appropriate time period determined by the purchaser, then
the purchaser shall have the right to withdraw fully or partially from the
Contract without compensation, or to require a reduction of the price, or to
demand that the supplier perform or have performed at his own cost repairs or
new product deliveries, or to demand compensation for nonperformance. This shall
also apply if the supplier declares that he is unable to remedy the defect or to
deliver a new product or service within an appropriate period of time.
(4) Repairs may be performed at supplier's cost without the specification of a
time period if delivery is made following the onset of a delay and the purchaser
has an interest in immediate repair in order to avoid a delay or for other
reasons of urgency.
(5) The rights described above shall expire one year after the defect is
reported.
(6) More extensive legal rights, especially regarding reimbursement of costs for
useless work or processing, shall remain unaffected.

<PAGE>

(7) Complaints regarding defects may be raised within one month of product
delivery or performance of service or, if the defect is noticed only during
work, processing or utilization, with one month from the time that the defect is
detected.
(8) The aforementioned arrangements shall apply similarly for services performed
to remedy defects.
(9) The supplier shall bear the costs and risks for the return of defective
delivered products.

VII. SUBCONTRACTING ORDERS TO THIRD PARTIES

Orders may not be subcontracted to third parties without the written consent of
the purchaser, and such subcontracting shall entitle the purchaser to fully or
partly withdraw from the Contract or to demand compensation for damages.

VIII. MATERIAL PROVIDED BY THE PURCHASER

(1) Material provided by the purchaser shall remain the property of the
purchaser and must be separately stored, marked, and managed at no cost.
Provided material may be used only for the purchaser's orders. The supplier must
compensate the purchaser in the event of depreciation in value or loss. This
shall also apply for the authorized transfer of use of material associated with
the order.
(2) The material shall be processed or transformed for the purchaser. The
purchaser shall become the owner of the new or transformed item. If this is not
possible for legal reasons, then the purchaser and the supplier agree that the
purchaser shall become the owner of the new item at every point in time during
the processing and transformation. The supplier shall store the new item free of
charge for the purchaser, exercising due and proper care.

IX. TOOLS, MOLDS, SAMPLES, SECRECY, ETC.

Tools, molds, samples, models, sections, drawings, standards, printed materials,
and manuals provided by the purchaser, as well as items manufactured based upon
these materials, shall not without the written consent of the purchaser be
passed on to a third party nor used for purposes other than those specified in
the Contract. They shall be safeguarded against unauthorized inspection or use.
The purchaser may demand their return without prejudice to his other rights if
the supplier violates these obligations.

The supplier shall not disclose to third parties any information acquired from
the purchaser unless it is generally known or the supplier has legitimately
acquired knowledge of it in some other way.

X. ASSIGNMENT OF RECEIVABLES

No receivables shall be assigned without the purchaser's written consent.

<PAGE>

XI. ADDITIONAL PROVISIONS

Where points arise that are not covered by these conditions, the statutory
provisions shall apply.

XII. VENUE, APPLICABLE LAW

(1) If the supplier is listed in the Commercial Register, the venue shall be the
place from which the purchase order was issued.
(2) This Contract shall be subject to German law, excluding the United Nations
Convention on Contracts for the International Sale of Goods signed on April
11, 1980.

XIII. INSURANCE POLICIES

The product deliveries shall be insured for transportation by Bruker AXS
Analytical X-Ray Systems GmbH. The supplier must inform the carriers of the
SVS/RVS restrictions. The supplier must bear the costs of any SVS/RVS premiums.

<PAGE>

APPENDIX 3

                                   PRICE LIST

<TABLE>
<CAPTION>
-------------------------------------- ------------------------------------------- ------------------------------
      Purchase Order Number                           Price Basis                           Price / DM
             AXS                                                                        plus applicable VAT
-------------------------------------- ------------------------------------------- ------------------------------
<S>                                    <C>                                         <C>

C79298-A3208-Cxx(*1)                   [**]unit quantities                         [**]
(glued, bent, inspected)
                                                                                   to be negotiated

                                                                                   per agreement
custom designs
(to be specified)
-------------------------------------- ------------------------------------------- ------------------------------
</TABLE>

(*1) = C30,C31, C32, C33, C34, C35 and multi-layer with similar specifications.

Both parties reserve the right to price adjustments to compensate for cost
increases as well as in response to changes in the market price.

[**] Indicates that information has been omitted and filed separately with the
Commission pursuant to a request for confidential treatment.

<PAGE>

                          ACKNOWLEDGMENT OF TRANSLATION

                                 August 14, 2001

         The undersigned officer of the Registrant hereby acknowledges on behalf
of the Registrant that the foregoing translation of the Supply Agreement between
Bruker AXS GmbH and GKSS Forschungszentrum Geesthacht GmbH is a fair and
accurate English translation from German of the original executed agreement.

                                           BRUKER AXS INC.

                                           By: /s/ Martin Haase
                                              ----------------------------------
                                              Martin Haase, President and Chief
                                              Executive Officer

<Page>

BRUKER
   AXS

GKSS Forschungszentrum                                  Name: Barbara Schimmel
Mr. C. Schroder                                         Department: AXS EK
BTT/VJD                                                 Telephone: 0721/595-5521
Max-Planck-Strasse                                      Fax: 0721/595-2111
21502 Geesthacht                                        Your letter:
                                                        Our
                                                        Date: May 30, 2001

MULTILAYER X-RAY MIRROR CONTRACT GKSS NO. P 3.3.02.F.02

Dear Mr. Schroder:

We hereby propose amending clause 8 of the above-referenced contract (term of
contract) to read as follows:

Bruker AXS GmbH agrees, from 10/01/01 to 09/30/03, to purchase at least [**] of
x-ray mirrors. The contract may be cancelled at earliest on 09/30/03 with 3
months notice. Thereafter, it will be renewed [automatically] for one year,
unless it is cancelled 3 months prior to expiration.

All other clauses of the contract remain valid as they stand.

Sincerely,
/s/  Barbara Schimmel

Bruker AXS GmbH

                                  [letterhead]

[**]     Indicates that information has been omitted and filed separately with
         the Commission pursuant to a request for confidential treatment.

<PAGE>

                                                                            GKSS
                                                               FORSCHUNGSZENTRUM

GKSS P.O. Box [illeg.] D-21502 Geesthacht

GKSS Forschungszentrum
Max-Planck-Strasse
D-21502 Geesthacht
Telephone, main office: 04152/87 - 0
Fax, main office: 04152/87 - 1403
Internet: http://www.gkss.de

Bruker AXS GmbH
Ms. Barbara Schimmel
P.O. Box
76181 Karlsruhe

Your reference/ Our reference       Phone extension  Fax extension    Date
Your message    BTT/VJD(beta)Scho   04152-87-1722    04152-87-1818[?] [illeg.]
05/30/01

MULTILAYER X-RAY MIRROR CONTRACT GKSS NO. P 3.3.02.F.02 - NEW: 3.T4.00.F.03

Dear Ms. Schimmel:

We are hereby pleased to confirm that we agree with the proposal you make in
your letter of 05/08/01 to amend clause 8 of our contract regarding term and
cancellation options, while the rest of the contract continues to be valid,
though with amended annexes 1 and 3. For the above, please refer our letter of
05/30/01.

Sincerely,

GKSS Forschungszentrum Geesthacht GmbH
/s/ C. Scherg                  /s/ C/ Schroder
(Chr. Scherf)                  (C. Schroder)

                                  [letterhead]

<PAGE>

                          ACKNOWLEDGMENT OF TRANSLATION

                                 October 6, 2001

         The undersigned officer of the Registrant hereby acknowledges on behalf
of the Registrant that the foregoing translation of the letters of extension
relating to the Supply Agreement between Bruker AXS GmbH and GKSS
Forschungszentrum Geesthacht GmbH is a fair and accurate English translation
from German of the original executed agreement.

                                          BRUKER AXS INC.
                                          By: /s/ MARTIN HAASE
                                             -----------------------------------
                                             Martin Haase, President and Chief
                                             Executive Officer<PAGE>

                                                                   Exhibit 10.15

                          STRATEGIC ALLIANCE AGREEMENT

         This Strategic Alliance Agreement ("Agreement") is made and entered
into as of October 2, 2001 by and between Bruker AXS Inc., a Delaware
corporation with its principal place of business in Madison, Wisconsin
("BAXS") and GeneFormatics Incorporated, a California corporation with its
principal place of business in San Diego, California ("GFI").

                                   WITNESSETH:

         WHEREAS, GFI is a leading structural proteomics company which intends
to conduct a round of financing with respect to GFI's Series C Preferred Stock
("Series C Financing") and to purchase from BAXS X-ray single crystal
diffraction ("XSCD") systems and related equipment ("XSCD Products");

         WHEREAS, BAXS is a leading XSCD company which desires to (i) sell to
GFI XSCD Products and to provide certain support and maintenance services
relating thereto, and (ii) make a One Million Dollar ($1,000,000) investment
in GFI as part of the Series C Financing ("BAXS Investment"); and

         WHEREAS, the parties desire to work together with respect to XSCD for
structural proteomics;

         NOW, THEREFORE, in consideration of the foregoing and the mutual
covenants contained herein, the parties hereto hereby agree as follows:

         1.0 TECHNOLOGICAL COLLABORATION

         The parties shall work together in the following areas as may be
mutually agreed from time to time:

CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS
EXHIBIT, WHICH PORTIONS HAVE BEEN OMITTED AND REPLACED WITH [**] AND FILED
SEPARATELY WITH THE COMMISSION.

<PAGE>

             1.1 GFI shall make a material investment in XSCD. GFI is in the
process of developing a specific XSCD strategy in conjunction with Tony
Kossiakoff, Ph.D., a world class XSCD scientist at the University of Chicago
and an exclusive consultant to GFI in the fields of structural genomics and
structural proteomics.

             1.2 In conjunction with developing such strategy, GFI shall work
with BAXS to incorporate BAXS' capabilities into such strategy. This shall
include, among other items, the following:

                 1.2.1 It is anticipated that GFI will initially [**]from
BAXS.

                 1.2.2 It is anticipated that, as part of a second phase, GFI
may expand its technology platforms for protein structure and function
discovery by [**].

             1.3 The XSCD lab at GFI may serve as a test site for future
capabilities.

             1.4 GFI may provide BAXS access to GFI's experimental protocols and
methods for automated crystallization and sample purification and preparation.

         2.0 INVESTMENT

             GFI intends to undergo a Series C Financing during the calendar
year 2001. BAXS shall make the BAXS Investment in cash and stock as part of
the Series C Financing; provided, however, that such investment is required
to be made by BAXS only if GFI closes the Series C Financing during the 2001
calendar year and GFI receives at least [**] in such Series C Financing
(including the BAXS Investment and the investments of any affiliates of
BAXS). The BAXS

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

                                       2
<PAGE>

Investment shall be comprised of $500,000 of cash and $500,000 of BAXS stock.
The BAXS stock shall be valued at (a) if the Series C Financing closes prior
to September 15, 2001, $7.00 per share; and (b) if the Series C Financing
closes after September 15, 2001, (i) the fair market value thereof as
determined by the BAXS Board of Directors in agreement with GFI if the
initial public offering of BAXS has not yet been declared effective, or (ii)
the average closing price over the ten (10) NASDAQ trading days ending three
(3) days prior to the closing date of the Series C Financing, if the initial
public offering of BAXS has been declared effective. BAXS' completion of the
BAXS Investment is subject to the following:

             2.1 BAXS shall invest at a valuation and on terms and conditions no
less favorable than those provided to any other investor in GFI's Series C
Preferred Stock.

             2.2 If such Series C Financing is not closed on or before December
31, 2001, this Section 2.0 shall be of no further force or effect.

         3.0 SALE AND PURCHASE OF XSCD PRODUCTS

             Subject to closing of the BAXS Investment, GFI may from time to
time submit purchase orders for XSCD Products.

         4.0 PREFERRED CUSTOMER STATUS

             Given the parties' desire to create a strategic alliance
hereunder, BAXS shall sell XSCD Products and support to GFI at [**] prices,
terms, and other conditions; provided, however, GFI acknowledges that this
also has to be a win-win situation for BAXS, and that BAXS needs to receive
its [**] margins on any purchases of XSCD Products and support by GFI.

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

                                       3
<PAGE>

         5.0 EXPENSES

             Each party shall be responsible for its own expenses in connection
with the execution of, and performance under, this Agreement.

         6.0 EXCLUSIVITY

             Subject to the terms and conditions contained herein and except for
XSCD Products not offered by BAXS, for the term of this Agreement, including any
extension thereof, BAXS shall be the sole and exclusive supplier of XSCD
Products to GFI.

         7.0 TERM

             7.1 The term of this Agreement shall commence as of the date of
this Agreement and continue for three (3) years thereafter, unless terminated
earlier as set forth herein. Upon mutual written agreement of the parties
prior to each expiration date, the term of this Agreement may be extended for
a series of successive two (2) year periods.

             7.2 Either party may terminate this Agreement effective immediately
and without liability upon written notice to the other party if any one of the
following events occurs: (a) the other party files a voluntary petition in
bankruptcy or otherwise seeks protection under any law for the protection of
debtors; (b) a proceeding is instituted against the other party under any
provision of the Federal Bankruptcy Code or equivalent legislation of a foreign
jurisdiction which is not dismissed within ninety (90) days; (c) the other party
is adjudicated bankrupt; (d) a court assumes jurisdiction of the assets of the
other party under a federal reorganization act or equivalent legislation of a
foreign jurisdiction; (e) a trustee or receiver is appointed by a court for all
or a substantial portion of the assets of the other party; (f) the other party
becomes insolvent, ceases or suspends

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

                                       4
<PAGE>

business; (g) the other party makes an assignment of the majority of its assets
for the benefit of its creditors, or (h) the BAXS Investment is not made in
calendar year 2001.

             7.3 Either party may terminate this Agreement effective
immediately and without liability upon written notice to the other party if a
party breaches a material obligation hereunder and does not cure such breach
within [**] after receiving notice of such breach from the other party.

             7.4 The provisions of Sections 5, 7.4, 8, 10 and 11 shall survive
termination or expiration of this Agreement.

         8.0 CONFIDENTIALITY

             Each party shall itself, and shall cause its employees to, keep
confidential and refrain from using, except to the extent necessary to perform
the obligations set forth under this Agreement, all technology and all
confidential business and technical information disclosed to such party by the
other party. The foregoing shall not apply to such information that a party can
demonstrate (i) was known to such party before it was disclosed to such party,
(ii) was known to the public at the time of disclosure, or subsequently becomes
so known through no act or omission of such party, (iii) is received by such
party from a third party not under any obligation of confidentiality, (iv) is
owned by such party or (v) is developed by such party independently of any
disclosure hereunder. A party shall disclose such confidential information of
the other party only to those of its employees having a need to know and who
have agreed to be bound by duties of confidentiality no less protective than
those contained herein.

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

                                       5
<PAGE>

         9.0 PUBLICITY

             Promptly upon the execution of this Agreement, the parties shall
issue a mutually agreeable joint press release which shall refer to the parties'
strategic relationship and BAXS' equity investment in GFI.

         10.0 OWNERSHIP

              10.1 This Agreement shall not give either party any ownership
interest in or rights to the patent rights, copyrights, trade secrets or any
other intellectual property rights ("IP Rights") of the other party, and all IP
Rights that are owned or controlled by a party at the commencement of this
Agreement shall remain under the ownership or control of such party.

              10.2 Each party shall own the entire right, title and interest in
any inventions, discoveries, improvements, works of authorship, computer
software, algorithms, or the like it may invent, make, author, or otherwise
develop under or in connection with this Agreement, including all IP Rights
relating thereto. Such party shall have the sole authority to determine what
intellectual property protection, if any, it desires to seek for such items.

              10.3 The parties [**] all inventions, discoveries,
improvements, works of authorship, computer software, algorithms, or the like
they [**] invent, make, author, or otherwise develop under or in connection
with this Agreement, and [**] determine what intellectual property
protection, if any, they desire to seek for such items.

         11.0 MISCELLANEOUS PROVISIONS

              11.1 This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware.

[**] Indicates that information has been omitted and filed separately with
the Commission pursuant to a request for confidential treatment.

                                       6
<PAGE>

              11.2 Nothing contained herein shall be construed as constituting a
joint venture, partnership or other form of business organization. The parties
have entered into this Agreement solely as independent contractors, and neither
party shall have any authority to bind or commit the other party.

              11.3 All notices given hereunder shall be in writing, sent by
certified mail, return receipt requested, addressed as follows, provided that a
party may change its address for notices by notice thereof:

                  If to BAXS:     Bruker AXS Inc.
                                  5465 E. Cheryl Parkway
                                  Madison, WI 53711
                                  Attn.:  President

                  If to GFI:      GeneFormatics Incorporated
                                  5830 Oberlin Drive, Suite 200
                                  San Diego, CA 92121-3754
                                  Attn.:  President and Chief Executive Officer

              11.4 This Agreement shall be binding upon and inure to the benefit
of the parties hereto and their respective successors and assigns.

              11.5 This Agreement constitutes the entire agreement between the
parties concerning its subject matter and supersedes any prior or
contemporaneous agreements and understandings in connection therewith,
including, without limitation, that certain Non-Binding Letter of Intent for
Strategic Partnership in Structural Proteomics by and among GFI, BAXS and
certain affiliates of BAXS. This Agreement may be amended or waived only by a
written instrument executed by both parties.

                                       7
<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first written above.

GENEFORMATICS INCORPORATED                 BRUKER AXS INC.

By: /s/ John P. Schmid                     By: /s/ Martin Haase
   --------------------------                  -------------------------------

Title: Chief Financial Officer             Title: President and
      -----------------------                       Chief Executive Officer
                                                  ----------------------------

                                       8

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