Document:

Sales Force Work Order

 Exhibit 10.45 
  
 AMENDED AND RESTATED SALES FORCE WORK ORDER # 8795 AND 
 TERMINATION OF WORK ORDER #8872 
  
 EFFECTIVE DATE: January 26, 2004 
  
 This Amended and Restated
Sales Force Work Order is entered into between Columbia Laboratories, Inc., (“Columbia”) and Innovex Inc. (“Innovex”), pursuant to the Master Services Agreement, having an effective date of July 31, 2002, between Columbia and
Innovex’s predecessor, Innovex LP, and is subject to all the terms and conditions set forth therein, except as may be otherwise expressly provided herein. Sales Force Work Order #8872 is hereby terminated and no longer in effect. 

  

	A.	BRIEF DESCRIPTION OF SALES FORCE PROJECT: 

  
 Sales Force 
  
 A full time sales force will be assigned to selling Prochieve® 8% Progesterone Gel (“Prochieve 8%”), Prochieve® 4% Progesterone Gel (“Prochieve 4%”), RepHresh® Vaginal Gel
(“RepHresh”), and Advantage-S® Bioadhesive Contraceptive Gel (“Advantage-S”) to a target list of obstetricians, gynecologists, and primary care physicians, and selling StriantTM Testosterone Buccal System (“Striant”) to a target list of endocrinologists,
urologists, and primary care physicians. Columbia’s and Innovex’s objective is to maximize the quality of the calls and to work the total office to support the full Columbia product line. 
  
 The parties acknowledge and agree that the grant of rights to Innovex hereunder is
non-exclusive and nothing herein shall limit or restrict Columbia’s right to market or promote the Products itself or through a third party, in Columbia’s sole discretion. 
  

	B.	PROJECT TEAMS: 

  

			
	Columbia Contact Person:	  	     Meg Coogan

	 	  	     Senior Vice President, Marketing and Sales

	address:	  	     354 Eisenhower Parkway

	 	  	     Livingston, NJ 07039

	phone:	  	     973-994-3999

	fax:	  	     973-994-3001

		
	Innovex Contact Person:	  	     Tony Yost

	 	  	     President

	address:	  	     10 Waterview Blvd.

	 	  	     Parsippany, NJ 07054

	phone:	  	     973-257-4500

	fax:	  	     973-257-4617

  

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 Routine correspondence relevant to the operation of the sales force should be sent to the above-named contact persons.
All notices or similar communications in regard to the terms of this Amended and Restated Sales Force Work Order are to be sent to the parties named in Section 16 of the Master Services Agreement. 
  

	C.	PROJECT TERM AND KEY DATES: 

  

			
	 Project Start Date
	 	 July 31, 2002

	 Last Innovex Sales Representative Field Day
	 	 October 31, 2005

	 Project End Date
	 	 October 31, 2005

  
 “Project Term” shall mean
the period of time beginning on the Project Start Date and ending on the Project End Date. 
  

	D.	DEFINITIONS 

  

	 	1.	“Day Worked” shall mean a day during which an Innovex Sales Representative Details or Presents to Prescribers, or attends scheduled Columbia training and/or specifically
designated home study. A “Day Worked” by an Innovex District Manager shall mean a day during which the Innovex District Manager performs duties and responsibilities described in this Amended and Restated Sales Force Work Order. A “Day
Worked” by an Innovex Field Coordinator shall mean a day during which the Innovex Field Coordinator performs duties and responsibilities described in this Amended and Restated Sales Force Work Order. Days Worked shall not include days on leave,
holidays, sick days, or vacations. 

  

	 	2.	“Detail” shall mean an interactive face-to-face contact by an Innovex Sales Representative with a Prescriber, during which a promotional message involving Prochieve 8%,
Prochieve 4%, or Striant is given in accordance with the Promotional Program. When used as “Detail,” “Details,” “Detailing” or “Detailed,” it shall mean to engage in a Detail as defined herein.

  

	 	3.	“Innovex District Manager” shall mean an Innovex employee who is a district manager and who, among other things, manages and supervises Innovex Sales Representatives.

  

	 	4.	“Innovex Field Coordinator” shall mean an Innovex employee who, among other things, manages and supervises Innovex Sales Representatives with respect to personnel matters.

  

	 	5.	“Innovex National Field Coordinator” shall mean the Innovex employee who, among other things, manages and supervises the Innovex Field Coordinators.

  

	 	6.	“Innovex Sales Force” shall mean the Innovex Sales Representatives, Innovex Field Coordinators and the Innovex National Field Coordinator, individually and as a group,
that have been assigned by Innovex to deliver Details and Presentations of Products in accordance with the terms of this Amended and Restated Sales Force Work Order. 

  

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	 	7.	“Innovex Sales Representative” shall mean an Innovex employee who has been trained and equipped to Detail and Present to Prescribers. 

  

	 	8.	“Off-limits Prescriber” shall mean one of the Prescribers specifically identified by Columbia within an Innovex Sales Representative’s Territory that the Innovex
Sales Representative is prohibited from contacting. 

  

	 	9.	“Prescriber” shall mean physicians and other health care professionals legally authorized to write prescriptions for pharmaceutical products. 

  

	 	10.	“Presentation” shall mean an interactive face-to-face contact by an Innovex Sales Representative with a Prescriber or the Prescriber’s staff, during which a
promotional message involving RepHresh or Advantage-S is given in accordance with the Promotional Program. When used as “Present,” “Presents,” “Presenting” or “Presented,” it shall mean to engage in a
Presentation as defined herein. 

  

	 	11.	“Product” shall mean, individually and collectively, Prochieve 4%, Prochieve 8%, Advantage-S, RepHresh and Striant. 

  

	 	12.	“Promotional Material” shall mean the Product labeling and package inserts, sales aids, Detailing materials, Presentation materials, and other promotional support items
provided by Columbia to Innovex for use in promotion of a Product. 

  

	 	13.	“Promotional Program” shall mean the marketing plan, strategy and promotional message for each Product, as provided by Columbia, which will include use of the Promotional
Material. 

  

	 	14.	“Referral Message” shall mean the promotional message, as provided by Columbia, that any patient who has not become pregnant after three (3) cycles of treatment using
clomiphene citrate together with Prochieve 8% should seek care of an assisted reproductive technology specialist for further treatment. 

  

	 	15.	“Target Prescriber” shall mean one of the specifically identified Prescribers within an Innovex Sales Representative’s Territory to be Detailed and Presented to by
the Innovex Sales Representative. 

  

	 	16.	“Territory” shall mean the United States and Puerto Rico. In connection with an individual Sales Representative, the Territory shall be the geographic area assigned to the
individual Sales Representative. 

  

	E.	INNOVEX RIGHTS, RESPONSIBILITIES AND OBLIGATIONS 

  

	 	1.	Innovex Continuing Sales Force. As of the Effective Date of this Amended and Restated Sales Force Work Order, Innovex will provide the Innovex Sales Force

  

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	 	  	composed of Innovex District Managers and Innovex Sales Representatives (the “Innovex Continuing Sales Force”) assigned to Work Orders #8795 and #8872 on the date
immediately preceding the Effective Date. The Innovex Continuing Sales Force will perform the obligations of Innovex pursuant to this Amended and Restated Sales Force Work Order until the establishment of the Columbia Re-Aligned Sales Force in
accordance with paragraph E(2) of this Amended and Restated Sales Force Work Order. 

  

	 	2.	Columbia Re-Aligned Sales Force. Within thirty days of the Effective Date of this Amended and Restated Sales Force Work Order, Columbia, within its sole discretion but on the
basis of analyses and recommendations of [***], will determine the number and placement of districts and Territories for a nationwide sales force of Columbia district managers, Columbia sales representatives and Innovex Sales Representatives
(the “Columbia Re-Aligned Sales Force”) and the Steering Committee will agree on a date within such thirty day period to terminate those members of the Innovex Continuing Sales Force that will not be part of the Columbia Re-Aligned Sales
Force and institute the Columbia Re-Aligned Sales Force (the “Re-Alignment Date”). Columbia may, in its sole discretion and with no payment or other obligation to Innovex whatsoever (notwithstanding any other provision of this Amended and
Restated Sales Force Work Order), hire directly any Innovex District Manager in the Innovex Continuing Sales Force to be a Columbia district manager in the Columbia Re-Aligned Sales Force. Innovex will provide to Columbia pursuant to this Amended
and Restated Sales Force Work Order Innovex Sales Representatives equal in number to one-half the number of sales Territories established by Columbia on the Re-Alignment Date (the “Innovex Sales Representative Threshold”). The Innovex
Sales Force which will constitute part of the Re-Aligned Sales Force may be recruited from within or without the Innovex Continuing Sales Force and will be selected in accordance with the provisions of paragraph E(3), below. Columbia will hire
directly sales representatives for one-half the number of sales Territories established by Columbia on the Re-Alignment Date. Columbia will provide appropriate sales and marketing oversight of the Innovex Sales Force, including the provision of a
Columbia national sales director and district managers. Beginning on the Re-Alignment Date, Columbia shall be entitled, in its sole discretion, to select, appoint and hire all district managers. Innovex will provide Innovex Field Coordinators and an
Innovex National Field Coordinator for the Innovex Sales Force. Columbia may request that Innovex provide additional Innovex Sales Representatives for the Columbia Re-Aligned Sales Force by submitting a written request in substantially the form
attached hereto as Exhibit 1, (“Additional Innovex Sales Representative Request Form”). If after the Re-Alignment Date Columbia in its sole discretion reduces the number of Territories to be covered by the Columbia Re-Aligned Sales Force
below the number of Territories on the Re-Alignment Date, such reduction shall be allocated equally between the Innovex Sales Representatives and Columbia sales representatives. If after the Re-Alignment Date Columbia in its sole discretion
increases the number of Territories to be covered by the Columbia Re-Aligned Sales Force from the number of Territories on the Re-Alignment Date, such increase may be made solely by Columbia hiring new sales representatives directly,

  

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	 	  	with no obligation of Columbia to increase the number of Innovex Sales Representatives; provided, however, that (i) any increase in Territories made within the first three months
after the Re-Alignment Date shall be allocated equally between the Innovex Sales Representatives and Columbia sales representatives and the Innovex Sales Representative Threshold shall be increased by the number of Innovex Sales Representative so
added; or (ii) if the number of Innovex Sales Representatives at the time of such increase is less than the Innovex Sales Representative Threshold, then the increase shall be allocated equally between the Innovex Sales Representatives and Columbia
sales representatives until such time as the number of Innovex Sales Representatives equals the Innovex Sales Representative Threshold. As the total number of district managers changes for the Columbia Re-Aligned Sales Force, Innovex Field
Coordinators will also be added or removed in order to maintain a ratio Innovex Field Coordinators to district managers of no greater than 1:4 unless determined otherwise by the Steering Committee. 

  

	 	3.	Recruitment. 

  

	 	a.	Innovex shall be responsible for recruitment and re-recruitment (replacement) of the Innovex Sales Representatives and Innovex Field Coordinators in accordance with the Innovex
Sales Force Qualifications described below, subject to Columbia’s approval of each Innovex Sales Representative and Innovex Field Coordinator. Innovex shall be responsible for the cost of recruitment, background checks and drug screens.
Columbia shall approve or disapprove qualified candidates within five (5) business days after each qualified candidate is submitted to Columbia for final selection. A “qualified candidate” must meet the Innovex Sales Force Qualifications
set forth in paragraph E(4) of this Amended and Restated Sales Force Work Order and, in the reasonable judgment of Columbia, be capable of Detailing and Presenting the Products to Prescribers and their staffs in an effective manner.

  

	 	b.	At Columbia’s request, Innovex will provide recruiting services to Columbia with regard to Columbia’s recruitment of its own, directly employed, field sales force. The
scope and pricing of such services shall be determined by the Steering Committee. 

  

	 	4.	Innovex Sales Force Qualifications. Innovex will exercise best efforts to recruit from a diverse candidate base. A qualified candidate for Innovex Sales Representative shall
meet the following minimum qualifications: four-year college degree (B.A., B.S. or equivalent); minimum two years outside sales experience, preferably within pharmaceuticals and women’s health, endocrinology or urology. At least 50% of Innovex
Sales Representative candidates shall have a minimum of one year of pharmaceutical sales experience. 

  

	 	5.	Position Descriptions and Duties. Innovex shall evaluate the performance of the Innovex Sales Representatives, Innovex Field Coordinators, and the Innovex National Field
Coordinator in accordance with the responsibilities and duties identified below, 

  

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	 	    	giving at least 60% weight in the evaluation of Innovex Sales Representatives to the ability to generate sales within the assigned Territory. All Innovex Sales Force employees shall
demonstrate the following: work ethic and integrity; planning, organizing and territory management skills; strong interpersonal skills; excellent communication skills; critical thinking and analysis; problem solving; decisiveness; sound judgment;
Columbia-focused selling skills; basic computer skills; ability to listen and learn. 

  

	 	    	In addition, the responsibilities of the Innovex Sales Representatives, Innovex Field Coordinators and the Innovex National Field Coordinator shall include the following:

  
 Innovex Sales Representatives 

 

	 	•	Generate sales within the assigned Territory 

  

	 	•	Work a full 8 hours each field selling day 

  

	 	•	Achieve 90% or better on all product knowledge tests 

  

	 	•	Spend [***]of their Detailing time on Striant and [***] of their Detailing time on Prochieve 8% and Prochieve 4% 

  

	 	•	Make an average of [***] Details per day, calculated on a weekly basis, on the Target Prescribers within the Innovex Sales Representative’s call list for all products

  

	 	•	Make an average of [***] pharmacy calls per day, calculated on a weekly basis, on the pharmacy target list within the Innovex Sales Representative’s Territory

  

	 	•	Make an average of[***]calls per month on the [***]Striant Target Prescribers within the Innovex Sales Representative’s call list 

  

	 	•	Make an average of [***]calls per month on the [***]Prochieve 8% Target Prescribers within the Innovex Sales Representative’s call list 

 

	 	•	Make an average of [***]calls per month on the [***]Prochieve 4% Target Prescribers within the Innovex Sales Representative’s call list 

 

	 	•	Make one call per month on the remaining Target Prescribers within the Innovex Sales Representative’s call list up to the required call frequency 

  

	 	•	Make a full office staff Presentation (including OTC Products) on every call 

  

	 	•	Make laptop call note entries throughout each day (8:00 A.M—5:00 P.M.) 

  

	 	•	Synchronize his/her laptop a minimum of 1 time per day 

  

	 	•	Accurately document what takes place on every call, as well as specific plans for the next call. Maintain and update current and prospective Target Prescriber profiles. (Call notes
must be a succession of documentation, highlighting objectives, accomplishments, issues, objections and success planning.) 

  

	 	•	Check e-mail twice per day 

  

	 	•	Check voice mail three times per day 

  

	 	•	Avoid all contact whatsoever with Off-limits Prescribers 

  

	 	•	Keep current with market knowledge and competitive products 

  

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	 	•	Avoid any comparison or reference to Crinone® (progesterone gel) products marketed by Serono, Inc. 

  

	 	•	Maintain a professional image for Columbia and Columbia Products 

  

	 	•	Participate in all training and sales meetings 

  

	 	•	Plan and organize Territory to meet sales and call Target Prescribers 

  

	 	•	Make sales presentations (Details and Presentations) – individual, one-on-one, in-services 

  

	 	•	Deliver the Referral Message with each Detail of Prochieve 8% 

  

	 	•	Comply with the Prescription Drug Marketing Act and other applicable laws 

  

	 	•	Make complete, accurate and timely submission of all time-keeping, call activity and expense reports 

  

	 	•	Meet all specified timelines for submitting weekly reports, expense reports, and all other project specific reports 

  

	 	•	Comply with Promotional Program, and proper use of Promotional Materials 

  

	 	•	Participate or coordinate “Lunch & Learns,” dinner programs, weekend events, as appropriate 

  

	 	•	Have appropriate interaction with co-promotional partners or counterparts 

  
 Innovex Field Coordinators 
  

	 	•	Assist with recruitment of Innovex Sales Representatives and Columbia Sales Representatives 

  

	 	•	Handle initial 120 day and annual performance reviews, personnel issues, discipline and termination of Innovex Sales Representatives 

  

	 	•	Review and approve expense reports; monitor compliance with expense policies 

  

	 	•	Assess and monitor field activity and work schedules; monitor and manage field reporting; implement performance or disciplinary plans. 

  

	 	•	Communicate with Columbia district managers on a regular and timely basis 

  

	 	•	Assist with the planning and delivery of training, and periodic sales meetings 

  

	 	•	Monitor time-keeping and attendance 

  

	 	•	Monitors compliance with the Prescription Drug Marketing Act, other applicable laws and sample accountability procedures as applicable 

  
 Innovex National Field Coordinator 
  

	 	•	Manage and supervise Innovex Field Coordinators 

  

	 	•	Monitor compliance with Innovex Sales Representative re-recruitment process, including maintaining recruit profile integrity and ensuring Columbia review of recruits

  

	 	•	Track call activity 

  

	 	•	Ensure appropriate billing (both estimates and actuals) 

  

	 	•	Draft, compile and deliver monthly reports 

  

	 	•	Serve as Columbia’s main point of contact 

  

	 	•	Ensure appropriate follow-up on personnel and performance related issues 

  

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	 	6.	Innovex Sales Force Compensation; Benefits. Innovex shall administer the compensation plan for the Innovex Sales Force with a combination of salary and variable incentive
(bonus). The Steering Committee shall establish a target average salary and salary matrix, which recognizes greater experience and training, and preferred selection criteria. The terms and conditions of a variable incentive compensation plan for the
Innovex Sales Force (“Incentive Plan”) shall be determined by Columbia, including eligibility criteria and performance targets. The plan may also include incentive awards such as trips and prizes. Innovex shall administer the Incentive
Plan and pay the incentive compensation and awards in accordance with the Incentive Plan. Innovex Sales Force employees shall be eligible to receive an auto allowance, and shall be entitled to participate in the Innovex employee benefit plans for
health and dental care, 401K, in accordance with Innovex eligibility criteria. 

  

	 	7.	Training and Periodic Sales Meetings. Innovex shall facilitate the participation of the Innovex Sales Force in Columbia’s training of the Innovex Sales Force,
backfill training of replacement Innovex Field Coordinators and Innovex Sales Representatives and all follow-up training, including periodic sales meetings. Columbia may request Innovex’s participation in the delivery of training and Innovex
will provide such services on a time and materials basis as the parties may agree. In all cases, Innovex may have other appropriate personnel monitor and observe Columbia training (solely for purposes relating to the marketing of Products hereunder)
at Innovex’s sole cost and expense. Innovex may have Innovex Sales Force members participate in the Innovex Leadership Development Program at Innovex’s sole cost and expense. 

  

	 	8.	Promotional Activities. Columbia shall be responsible for managing and monitoring the promotional activities of the Innovex Sales Force. The Innovex Sales Force shall engage
in promotional activities in strict adherence to the Promotional Program and using only the Promotional Materials provided by Columbia. Innovex Sales Representatives shall not be permitted to develop, create or use any other promotional material or
literature in connection with the promotion of the Products. The Innovex Sales Representatives will be required to immediately cease the use of any Promotional Materials when instructed to do so by Columbia. Columbia shall monitor that Promotional
Materials are not changed, (including, without limitation, by underlining or otherwise highlighting any text or graphics or adding any notes thereto) by the Innovex Sales Representatives. Innovex Sales Representatives shall be required to limit
their statements and claims regarding Product, including as to efficacy and safety, to those which are consistent with the Product labels, package inserts and Promotional Materials. The Innovex Sales Representatives shall not be permitted to add,
delete or modify claims of the efficacy or safety in the promotion of the Products, nor shall the Innovex Sales Representatives be permitted to make any untrue or misleading statements or comments about the Products or any Columbia competitors or
competitor products. Innovex Sales Representatives shall be prohibited from (i) contacting Off-limits Prescribers and (ii) making comparisons or references to Crinone® products. 

  

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	 	9.	Project Reports. Innovex shall provide Columbia a monthly Project Report in respect of the activities of the Innovex Sales Force, which shall include: (i) headcount, reported
nationally, by district and Territory; vacancy rates, turnover, personnel transfers to Columbia, status of recruitment/hiring update; (ii) project status, milestones, and progress toward achieving objectives; (iii) call averages by district and
nationally, (iv) financial accountability, tracking expenses against budget; and (v) call reporting on a Territory-by-Territory basis, including reach and frequency, calls during the period on [***]Striant physicians, [***]Prochieve 8%
physicians, [***]Prochieve 4% physicians, pharmacies; office calls vs. physician calls; and times of call note entries. 

  

	 	10.	Reporting by Innovex Sales Representatives. Innovex Sales Representatives shall be required to report all field activities and expenditures to district managers and Innovex
Field Coordinators in a manner that is timely, accurate and honest, and in accordance with policies and procedures for the applicable reporting systems. Columbia district managers and Innovex Field Coordinators shall routinely reinforce the
importance of compliance with the reporting guidelines and policies (e.g. sample accountability, call reporting, promotional budget expenditures, travel expenses). Newly hired Innovex Sales Representatives shall receive training on the reporting
systems, guidelines and policies during the initial sales training program. 

  

	 	11.	SFA and Call Reporting. Innovex shall provide a sales force automation tool, including automated call reporting functions. Innovex shall equip the Innovex Sales Force with
computer hardware and software, and shall bear the cost of database and system administration, licenses, access to data/replication lines, help desk support, and training of the Innovex Sales Force in proper use of the computers and software.

  

	 	12.	Management and Discipline of the Innovex Sales Force. Columbia shall be responsible for managing the sales and marketing activities of the Innovex Sales Force. Innovex, in
light of its human resources responsibilities, shall have sole authority to remove employees from the Innovex Sales Force. The Steering Committee may establish minimum sales criteria for an Innovex Sales Representative to continue employment on the
Innovex Sales Force. In conformance with Innovex policy, Innovex shall provide appropriate employee counseling and discipline, up to and including termination, on its own initiative and upon the reasonable request of Columbia, to Innovex Sales Force
members who violate employment rules and who are otherwise under performing their job responsibilities. Innovex will promptly follow-up on any reports made by Columbia of Innovex Sales Force member non-compliance and will apply such counseling or
discipline as may be warranted in Innovex’s judgment consistent with Innovex’s prior employment practices and the reasonable requests of Columbia. 

  

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	 	13.	Business Cards; Detail Bags. Innovex shall supply the Innovex Sales Force with business cards, the content of which shall be subject to approval by Columbia, such approval
not to be unreasonably withheld. Innovex shall supply the Innovex Sales Force with Detail bags. Columbia shall provide Innovex with camera ready artwork of Columbia’s logo or other content Columbia wishes to include on the business cards.

  

	 	14.	Innovex Sales Force Performance. If the average number of combined prescriptions for Prochieve 4%, Prochieve 8% and Striant in September, 2004, for the Innovex Sales
Representatives based upon monthly IMS data is less than [***], the parties will meet on or before October 31, 2004, to discuss corrective measures or termination of this Amended and Restated Sales Force Work Order. The parties shall consider
all relevant factors, including, but not limited to, the analogous performance of the Columbia sales representatives, overall sales of the Products, entry of competitors (generic or branded), etc. 

  

	F.	COLUMBIA RIGHTS, RESPONSIBILITIES AND OBLIGATIONS 

  

	 	1.	Promotional Program and Promotional Materials. Columbia shall be responsible for providing a Promotional Program and Promotional Materials that (i) will not involve the
counseling or promotion of a business arrangement that violates federal or state law; (ii) will be in compliance with the PhRMA Code on Interactions with Healthcare Professionals; and (iii) shall not require or encourage the Innovex Sales
Representatives to offer, pay, solicit or receive any remuneration from or to Prescribers to induce referrals or to purchase Product. 

  

	 	2.	Training and Periodic Sales Meetings. 

  
 Columbia shall be responsible for the following: 
  

	 	•	Programming, materials and facilities for initial Innovex Sales Force training. The initial training agenda shall include time designated for Innovex training regarding personnel
management, compensation and benefits and field administration. 

  

	 	•	Programming, materials and facilities for periodic sales meetings or product launch meetings as designated by Columbia. 

  
 Any reasonable, documented and approved expenses incurred by Innovex in
conjunction with the Innovex Sales Force training shall be a Pass-Through Expense to Columbia. 
  

	 	3.	Sales Data. Columbia shall be solely responsible for obtaining historic and ongoing sales data regarding the Products. Columbia shall be solely responsible for paying any
applicable per representative fee required by any third party. Upon execution of this Amended and Restated Sales Force Work Order, Innovex will provide Columbia with the historic data used to size and structure the Innovex Sales Force. Columbia
shall provide Innovex with on going monthly IMS Xponent Data at the territory level for all sales representatives, Innovex and Columbia. 

  

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	 	4.	Innovex Sales Force Travel Expenses. Columbia shall be responsible for all reasonable Innovex Sales Force travel, lodging and meal expenses, when necessary, documented, and
actually incurred by the Innovex Sales Force. 

  

	 	5.	No Recruitment. Through the Project End Date and for one year thereafter, neither party shall attempt to actively recruit or solicit any personnel of the other party without
the prior written consent of such party; except as otherwise provided herein and provided that, notwithstanding the foregoing, a party shall be permitted to engage in general recruitment through advertisements or recruiting through head-hunters so
long as Innovex employees and personnel or Columbia employees and personnel, as the case may be, are not specifically targeted. 

  

	 	6.	Ancillary Services. Columbia may, upon 60 days prior notice to Innovex, assume direct responsibility for call reporting, sample accountability and reporting, and computers
and support services related to the Innovex Sales Force. 

  

	G.	FEES AND PASS-THROUGH EXPENSES 

  

	 	1.	Daily Fees. As of the Effective Date of this Amended and Restated Sales Force Work Order, Columbia shall pay Innovex a Daily Fee for each Day Worked by an Innovex Sales
Representative of [***], and each Day Worked by an Innovex District Manager of [***]. As of the Re-Alignment Date, Columbia shall pay Innovex a Daily Fee for each Day Worked during the Project Term by each Innovex Sales Representative,
each Innovex Field Coordinator, and the Innovex National Field Coordinator respectively as follows: [***]. In order to adjust for Innovex’s unamortized expenses incurred, the parties agree to renegotiate the Sales Representative Daily
Fee when and if the number of Innovex Sales Representatives becomes [***]above or below the Innovex Sales Representative Threshold. 

  
 The estimated Days Worked per year for each Innovex Sales Representative and Innovex Field Coordinator is [***]days. The Daily Fees may be
increased only with the prior written approval of Columbia; provided, however, that Innovex shall have no obligation to raise Innovex Sales Force salaries without Columbia’s agreement to raise the amount of such Daily Fees. 
  
 Salary Adjustments. The parties hereto hereby acknowledge and agree
that the Daily Fees set forth above are based upon an assumed average annual salary per Innovex Sales Representative of [***]. To the extent the Innovex Sales Representatives average salary is above or below [***] (annualized) in any
calendar month (or part thereof), Columbia shall pay to, or receive a credit from, Innovex in an amount equal to (i) the amount by which the average salary compensation earned by the Innovex Sales Representatives is greater or less than that amount,
plus (ii) an amount equal to [***]of such amount for Innovex’s employer costs (payroll taxes, benefits). 
  

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	 	2.	Recruiting Fee. For each Sales Force Member recruited by Innovex for backfill, Columbia shall pay Innovex a recruiting fee of [***], up to a maximum of [***].
After this backfill maximum fee is reached, further backfill recruiting shall be at Innovex’s sole cost and expense. Notwithstanding anything else herein to the contrary, the [***]fee shall always be due where the backfill is
necessitated by Columbia’s hiring of a member of the Innovex Sales Force or for any recruiting to fill a newly established Territory and the fee in such cases shall not be subject to, or counted against, the maximum fee set forth herein.

  

	 	3.	Take-On Fee. 

  

	 	a.	Individual Innovex Sales Force Members. Innovex may charge Columbia a fee for each Innovex Sales Force member that becomes employed by Columbia or an affiliate during the
Project Term (or six months thereafter if Columbia does not exercise its rollover rights with respect to such member under paragraph G(2)(b) of this Amended and Restated Sales Force Work Order), provided however, that Columbia may only hire an
Innovex Sales Force member during such period upon providing Innovex 15 days notice of Columbia’s desire to so hire and, in the case of Innovex Sales Representatives only upon Innovex express consent. For each such hire, Columbia shall pay
Innovex a one-time fee consisting of the following: [***] before October 31, 2004, and [***] thereafter, respectively, of the employee’s Innovex annual salary, as in effect immediately prior to such employee’s hiring by
Columbia. These amounts shall be included in Innovex’s regular invoicing. 

  

	 	(i)	Use of Take-on Fees. Innovex, in its sole discretion, may make the fees paid by Columbia under paragraph G(2)(a) of this Amended and Restated Sales Force Work Order available
for the Innovex Sales Force retention initiatives as may be warranted and prudent during the Project Term. The Steering Committee may make recommendations to Innovex on such expenditures. 

  

	 	b.	Innovex Sales Force Rollover. Columbia may hire directly any member of the Innovex Sales Force contemporaneously with the Project End Date by providing Innovex 90 days notice
and without any payment to Innovex, whatsoever. 

  

	 	4.	Pass-Through Expenses. Attachment A to this Amended and Restated Sales Force Work Order sets forth certain expenses which are “Pass Through Expenses.” Columbia
shall reimburse Innovex for any such Pass Through Expenses in accordance with the terms and conditions of this Amended and Restated Sales Force Work Order. 

  

	 	5.	Incentive Plan Administration. Columbia shall pay Innovex an amount equal to (i) the amount of all non-salary compensation earned by Innovex Sales Force members in accordance
with the terms of the Incentive Plan or the amount of other compensation 

  

 12 
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 SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

	 	    	otherwise requested by Columbia to be paid to the Innovex Sales Force; and (ii) an amount equal to [***]of such non-salary compensation for Innovex’s employer costs
(payroll taxes, benefits). 

  

	 	6.	SFA Fees. For Innovex’s provision of SFA services as set forth in paragraph E(11) of this Amended and Restated Sales Force Work Order, Columbia shall pay a monthly
service fee in the amount of [***]per Innovex Sales Representative, Innovex Field Coordinator, and the Innovex National Field Coordinator on staff during such month through the Project End Date. Columbia shall also pay Innovex [***]per
month for each Columbia sales representative, Columbia district manager and other employee of Columbia using the SFA system during such month. Provided, however, that the parties agree to renegotiate the monthly fee of [***], when and if the
number of monthly users (i) is reduced to fewer than 60, or (ii) increased to more than 135. 

  

	 	7.	Payment Schedule. Innovex shall send Columbia an itemized list of estimated costs for each month ten (10) days in advance, including all incentive compensation and related
employer costs, a list of the estimated billable Innovex Sales Force personnel and the estimated total number of Days Worked multiplied by the respective Daily Fee rate and all estimated Daily Fees, Take-on Fees and Pass-Through Expenses on a
Territory-by-Territory basis, and a district by district basis. Columbia shall pay the estimated monthly charge on the first day of the month by wire transfer to the account designated by Innovex. At the end of each calendar month Innovex shall
provide Columbia with an itemized list of the actual billable Innovex Sales Force personnel and the actual total number of Days Worked multiplied by the respective Daily Fee rate and all Daily Fees, Take-on Fees and Pass-Through Expenses on a
Territory-by-Territory basis, and a district-by-district basis. Innovex shall add any underpayment to, and deduct any overpayment from, the next estimate sent to Columbia, with a final true-up payment to be made with respect to the last month of the
Project Term 30 days after the Project End Date. The format of the Innovex estimates and invoices should conform in all respects, except invoices shall also contain full details of all expenses reported by Innovex employees other than Innovex Sales
Representatives. The parties shall use good faith efforts to reconcile any disputed amount as soon as practicable. One half of any amount in dispute for more than 30 days shall be credited against the next estimate (provided the amount in dispute
was paid by Columbia based on a previous estimate) sent to Columbia and remain as a credit until the dispute is resolved. 

  

	 	8.	Fourth Quarter 2003 Rates. On or before January 31, 2004, Innovex shall credit Columbia with an amount equal to [***]of the aggregate amount of Daily Fees in Innovex
invoices for services rendered from October 1, 2003 through December 31, 2003, for Work Orders #8795 and #8872, which shall be no less than [***]. 

  

	 	9.	June 2004 Performance Bonus. If the average number of combined prescriptions for Prochieve 4%, Prochieve 8% and Striant in June 2004 for the Innovex Sales Representatives
based upon monthly IMS data is [***]or greater, Columbia will make a payment to Innovex on or before August 15, 2004, in an amount equal to [***]. 

  

 13 
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 SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

	 	10.	Changes in Scope; Additional Services. All prices and costs contained in this Amended and Restated Sales Force Work Order are subject to revision as agreed by Columbia and
Innovex to reflect changes in the scope of services being provided by Innovex. Additional services will be provided at Innovex’s normal and customary rates. 

  

	 	11.	Expense Allocation Chart. The financial responsibility of Innovex and Columbia for expenses and costs of Innovex Sales Force operation shall be allocated in accordance with
the terms of this Work Order, which are summarized for illustrative purposes in the “Innovex Sales Force Expense Allocation” chart (Attachment A). On or before February 27, 2004, Innovex shall make an accounting for, and credit to,
Columbia all phone, postage, supplies, miscellaneous charges, and auto costs in the Territories that were paid by Columbia under Work Orders #8795 and #8872 if, and to the extent, such costs and expenses exceed [***]and such expenses were not
otherwise approved by Columbia. 

  

	H.	ADDITIONAL TERMS 

  

	 	1.	Steering Committee. Columbia shall make all decisions with respect to the strategy for the marketing and promotion of the Products. However, other issues may arise under the
terms of this Amended and Restated Sales Force Work Order or between the parties while operating under this Amended and Restated Sales Force Work Order which are appropriate for consultation between the parties to ensure maximum productivity of the
Innovex Sales Force, including, but not limited to, the establishment of work rules or the response to greater than expected Innovex Sales Force turnover or lower than expected Innovex Sales Force performance, and other changing market conditions.
The parties shall, therefore, establish a Steering Committee, chaired by Columbia and consisting of up to three (3) members from each party. The chairperson’s duties shall include site selection, logistics, agenda and facilitation; provided
however, that an Innovex Committee member may submit agenda items to the Chair and such items shall be included in the next regular meeting of the Steering Committee. The initial Innovex members are Tony Yost, Daryl Gaugler, and Ed Heimers, and the
initial Columbia members are Fred Wilkinson (chair), Meg Coogan, and Bill Reggio. A member of the Committee may be removed and replaced at any time, with or without cause, and replaced by the party that appointed such member. The Committee shall
meet at least monthly, or otherwise at the call of the chairperson to review, coordinate, and discuss issues regarding the Project. In addition, the Committee shall review and attempt to resolve issues pertaining to this Amended and Restated Sales
Force Work Order. The members of the Committee will use reasonable efforts to reach consensus on all decisions. For decisions concerning the day-to-day operations of the Re-Aligned Sales Force (such as discretionary spending for promotional expense
monies, incentive compensation payments, revision of Sales Force responsibilities), for which the Steering Committee cannot reach consensus, the chair shall cast the deciding vote. Notwithstanding anything else to the contrary, the Steering
Committee shall have no authority to alter the basic economic terms of this Amended and Restated Work Order, including the pricing terms, the number of members of the Innovex Sales Force, and the Project End Date. 

  

 14 
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 SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

 In Witness Whereof, Columbia and Innovex have each caused this Amended and Restated Sales Force Work Order #8795 to be
duly executed on their behalf by their authorized representatives and made effective as of Effective Date of Work Order appearing above. 
  
 Accepted and Agreed to by: 
  
  

							
	COLUMBIA LABORATORIES, INC.	 	INNOVEX, INC.
		
	 /S/ Fred Wilkinson

	 	 /S/ Anthony J Yost

	 By:
	 	 Fred Wilkinson
	 	 By:
	 	 Anthony J Yost

	 Title:
	 	 President & CEO
	 	 Title:
	 	 President

	 Date:
	 	 January 26, 2004
	 	 Date:
	 	 January 26, 2004

  

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 SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

 Attachment A to Sales Force Work Order  
 SALES FORCE EXPENSE ALLOCATION  
 Project # 8795 
  

							
	 Category

	  	 Innovex
 Direct
 Expenses

	  	PassThrough
Expenses

	  	 Columbia
 Direct
 Expenses

				
	Salary, including payroll taxes, for Innovex Sales Representatives, Innovex Field Coordinators and the Innovex National Field Coordinator. Incentive compensation for Innovex Field Coordinators,
compensation for the Innovex National Field Coordinator.	  	X	  	 	  	 
				
	Incentive compensation (bonus) for Innovex Sales Representatives, plus [***]	  	 	  	X	  	 
				
	Benefits package, including (401k), medical, dental, Rx, vacation, holidays	  	X	  	 	  	 
				
	Auto Costs in Territory, including monthly allowance, mileage reimbursement, parking and tolls.	  	X	  	 	  	 
				
	Basic Business Expenses in Territory, including phone, paper supplies, postage and voice mail.	  	X	  	 	  	 
				
	Business Cards & Detail Bags for Innovex Sales Force members	  	X	  	 	  	 
				
	Call Reporting; SFA	  	X	  	 	  	 
				
	Computers for Innovex Sales Representatives, including software, helpdesk support, data/replication lines	  	X	  	 	  	 
				
	Computers for FCs, NFC, including software, helpdesk support, data/replication lines	  	X	  	 	  	 
				
	Infrastructure support (operations, HR, finance, legal)	  	X	  	 	  	 
				
	Liability Insurance: employment, workers comp, E & O, CGL, auto	  	X	  	 	  	 
				
	Recruitment and re-recruitment, includes drug screens, background and motor vehicle checks	  	X	  	 	  	 
				
	Meetings: Columbia national, regional and district meetings; product launches	  	 	  	X	  	 
				
	Access Money, Lunch and Learn and Speaker Programs	  	 	  	X	  	 
				
	Promotional Program and Promotional Materials (sales aids)	  	 	  	 	  	X
				
	Promotional marketing expenses, including sales data	  	 	  	 	  	X
				
	Training program, materials and facilities; initial and follow-up	  	 	  	 	  	X
				
	 Travel Expenses (air, hotel, meals, T&E) for Innovex Sales Representatives, Innovex Field Coordinators, and the Innovex National Field
Coordinator

 *  Interviewing
 *  Territory travel for field management purposes
	  	 	  	X	  	 

  

 16 
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 SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

 EXHIBIT 1 to Amended and Restated Sales Force Work Order 
 ADDITIONAL INNOVEX SALES REPRESENTATIVE REQUEST FORM 
  
 This Request for Additional Innovex Sales Representative is issued pursuant to the Master Sales Services Agreement between Columbia and Innovex LP, dated as of July 31,
2002, and Amended and Restated Sales Force Work Order #8795, dated as of January 16, 2004. 
  

			
	PART 1	  	 To be completed by Columbia
  
 Attach any relevant, helpful information

	 NUMBER OF SALES REPS. REQUESTED
	  	 
		
	 TERRITORY LOCATION(S)
	  	 
		
	 REQUESTED START DATE
	  	 
		
	 AUTHORIZED COLUMBIA REPRESENTATIVE SUBMITTING REQUEST
	  	 Signature:
                                        
    
 Name:
 Title:
 Date:
 Phone:
 Fax:

		
	PART 2	  	 To Be Completed by Innovex
 Innovex shall respond within ten (10) business days after receipt of the Additional Innovex Sales Representatives Request.

		
	 This Additional Innovex Sales Representative Request Form was Received by Innovex on the following date:
  

	  	 Request is Accepted, and Recruitment shall begin immediately:
  

 (sign and date)
 Contact Person:
 Phone:

		
	 	  	 Request is Not Accepted (identify above information which must be clarified or changed before Request may be accepted by
Innovex):
  
  
  

 (sign and date)
 Contact Person:
 Phone:

  

 17 
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 SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.Form of Indemnification

 Exhibit 10.46 
  
 INDEMNIFICATION AGREEMENT 
  
 This Agreement is made and entered into this              day of
                    , 2004 (“Agreement”) by and between Columbia Laboratories, Inc., a Delaware corporation
(“Corporation”) and                      (“Indemnitee”). 
  
 WHEREAS the Board of Directors (the “Board”) has determined that the best interests of the Corporation require
that persons serving as directors of, and in other capacities for, the Corporation receive better protection from the risk of claims and actions against them arising out of their service to and activities on behalf of such corporations; and

  
 WHEREAS, this Agreement is a supplement to and in furtherance
of Article VI of the amended and restated by-laws of the Corporation, any rights granted by the Certification of Incorporation of the Corporation and any resolutions adopted pursuant thereto and shall not be deemed to be a substitute therefore nor
to diminish or abrogate any rights of the Indemnitee thereunder; and 
  
 WHEREAS, Indemnitee is willing to serve, continue to serve and take on additional service for or on behalf of the Corporation on the condition that Indemnitee be indemnified according to the terms of this Agreement; 
  
 NOW, THEREFORE, in consideration of the premises and the covenants contained
herein, the Corporation and Indemnitee do hereby covenant and agree as follows: 
  
 Section 1. Definitions. 
  
 For purposes
of this Agreement: 
  
 (a) “Change in Control” shall be
deemed to have occurred if (a) there shall have consummated (i) any consolidation or merger of Company in which Company is not the continuing or surviving entity or pursuant to which shares of Company’s common stock would be converted to cash,
securities or other property, other than a merger of Company in which the holders of Company’s common stock immediately prior to the merger have the same proportionate ownership of common stock of the surviving entity immediately after the
merger, or (ii) any sale, lease, exchange or transfer (in one transaction or a series of related transactions) of all, or substantially all, of the assets of the company; or (b) the stockholders of the Company approve a plan or proposal for the
liquidation or dissolution of the Company; or (c) any person (as that term is used in Sections 13(d) and 14(d)(z) of the Securities and Exchange Act, as amended (the “Exchange Act”)) shall become a beneficial owner (within the meaning of
Rule 13d-2 under the Exchange Act) of 40% or more of Company’s outstanding common stock; or (d) during any period of two consecutive years, individuals who at the beginning of such period constitute the entire Board shall cease for any reason
to constitute a majority thereof unless the election, or the nomination for election by Company’s stockholders, of each new director was approved by a vote of at least 50% of the directors eligible to vote who were directors at the beginning of
the period. 

 (b) “Disinterested Director” means a director of the Corporation who is not and was not a party
to the Proceeding in respect of which indemnification is sought by Indemnitee. 
  
 (c) “Effective Date” means                     . 
  
 (d) “Expenses” mean all reasonable attorneys’ fees, retainers,
court costs, transcript costs, fees of experts, witness fees, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees and all other disbursements and expenses of the type customarily incurred
in connection with prosecuting, defending, preparing to prosecute or defend, investigating, or being or preparing to be a witness in a Proceeding. 
  
 (e) “Independent Counsel” means a law firm, or a member of a law firm, that is experienced in matters of corporation law and neither presently
is, nor in the past five years has been, retained to represent: (i) the Corporation or Indemnitee in any other matter material to either such party, or (ii) any other party to the Proceeding giving rise to a claim for indemnification hereunder.
Notwithstanding the foregoing, the term “Independent Counsel” shall not include any person who, under the applicable standards of professional conduct then prevailing, would have a conflict of interest in representing either the
Corporation or Indemnitee in an action to determine Indemnitee’s rights under this Agreement. 
  
 (f) “Proceeding” means an action, suit, arbitration, alternate dispute resolution mechanism, investigation, administrative hearing or any other
proceeding, whether civil, criminal, administrative or investigative, except one initiated by an Indemnitee pursuant to Section 11 of this Agreement to enforce Indemnitee’s rights under this Agreement. 
  
 Section 2. Services by Indemnitee. 
  
 Indemnitee agrees to serve as an officer or director of the corporation,
and, at its request, as a director, officer, employee, agent or fiduciary of certain other corporations and entities. Indemnitee may at any time and for any reason resign from any such position (subject to any other contractual obligation or any
obligation imposed by operation of law). 
  
 Section 3. Indemnification -
General. 
  
 The Corporation shall indemnify, and advance
Expenses to, Indemnitee as provided in this Agreement to the fullest extent permitted by applicable law in effect on the date hereof and to such greater extent as applicable law may thereafter from time to time permit. The rights of Indemnitee
provided under the preceding sentence shall include, but shall not be limited to, the rights set forth in the other Sections of this Agreement. 
  
 Section 4. Proceeding Other Than Proceedings by or in the Right of the Corporation. 
  
 Indemnitee shall be entitled to the rights of indemnification provided in this Section if, by reason of Indemnitee’s
employment or service as an officer or director, Indemnitee is, or is threatened to be made, a party to any threatened, pending or completed Proceeding, other than a 
  

 2 

 Proceeding brought by or in the right of the Corporation to procure a judgment in its favor. Pursuant to this Section,
Indemnitee shall be indemnified against Expenses, judgments, penalties, fines and amounts paid in settlement, actually and reasonable incurred by Indemnitee or on Indemnitee’s behalf in connection with any such Proceeding if Indemnitee acted in
good faith and in a manner Indemnitee reasonably believed to be in or not opposed to the best interests of the Corporation, and, with respect to any criminal Proceeding, had no reasonable cause to believe Indemnitee’s conduct was unlawful.

  
 Section 5. Proceedings by or in the Right of the Corporation.

  
 Indemnitee shall be entitled to the rights of
indemnification provided in this Section if, by reason of his Corporate Status, Indemnitee is, or is threatened to be made, a party to any threatened, pending or completed Proceeding brought by or in the right of the Corporation to procure a
judgment in its favor. Pursuant to this Section, Indemnitee shall be indemnified against Expenses, judgments, penalties, fines and amounts paid in settlement, actually and reasonably incurred by Indemnitee or on Indemnitee’s behalf in
connection with any such Proceeding if Indemnitee acted in good faith and in a manner Indemnitee reasonably believed to be in or not opposed to the best interests of the Corporation. Notwithstanding the foregoing, no indemnification against such
Expenses shall be made in respect of any claim, issue or matter in any such Proceeding as to which Indemnitee shall have been adjudged to be liable to the Corporation if applicable law prohibits such indemnification unless the Court of Chancery of
the State of Delaware, or the court in which such Proceeding shall have been brought or is pending, shall determine that indemnification against Expenses may nevertheless be made by the Corporation. 
  
 Section 6. Indemnification for Expenses of a Party Who is Wholly or Partly
Successful. 
  
 Notwithstanding any other provision of
this Agreement, to the extent that Indemnitee is, by reason of Indemnitee’s employment or service as an officer or director, a party to and is successful, on the merits or otherwise, in any Proceeding, Indemnitee shall be indemnified against
all Expenses actually and reasonably incurred by Indemnitee or on Indemnitee’s behalf in connection therewith. If Indemnitee is not wholly successful in such Proceeding but is successful, on the merits or otherwise, as to one or more but less
than all claims, issues or matters in such Proceeding, the Corporation shall indemnify Indemnitee against all Expenses actually and reasonably incurred by Indemnitee or on Indemnitee’s behalf in connection with each successfully resolved claim,
issue or matter. For the purposes of this Section and without limiting the foregoing, the termination of any claim, issue or matter in any such Proceeding by dismissal, with or without prejudice, shall be deemed to be a successful result as to such
claim, issue or matter. 
  
 Section 7. Indemnification for Expenses of a
Witness. 
  
 Notwithstanding any other provision of this
Agreement, to the extent that Indemnitee is, by reason of Indemnitee’s employment or service as an officer or director, a witness in any Proceeding, Indemnitee shall be indemnified against all Expenses actually and reasonably incurred by
Indemnitee or on Indemnitee’s behalf in connection therewith. 
  

 3 

 Section 8. Advancement of Expenses. 
  
 The Corporation shall advance all Expenses incurred by or on behalf of Indemnitee in connection with any Proceeding within
thirty (30) days after the receipt by the Corporation of a statement or statement from Indemnitee requesting such advance or advances from time to time, whether prior to or after final disposition of such Proceeding. Such statement or statements
shall reasonably evidence the Expenses incurred by Indemnitee and shall include or be preceded or accompanied by an undertaking by or on behalf of Indemnitee to repay any Expenses advanced if it shall ultimately be determined that Indemnitee is not
entitled to be indemnified against such Expenses. 
  
 Section 9. Procedure
for Determination of Entitlement to Indemnification. 
  
 (a) To obtain indemnification under this Agreement in connection with any Proceeding, and for the duration thereof, Indemnitee shall submit to the Corporation a written request, including therein or therewith such documentation and
information as is reasonably available to Indemnitee and is reasonably necessary to determine whether and to what extent Indemnitee is entitled to indemnification. The Secretary of the Corporation shall, promptly upon receipt of any such request for
indemnification, advise the board in writing that Indemnitee has requested indemnification. 
  
 (b) Upon written request by Indemnitee for indemnification pursuant to Section 9(a) hereof, a determination, if required by applicable law, with respect to Indemnitee’s entitlement thereto shall be made in such
case: (i) if a Change in Control shall have occurred, by Independent Counsel (unless Indemnitee shall request that such determination be made by the Board or the stockholders in the manner provided for in clauses (ii) or (iii) or this Section 9(b))
in written opinion to the Board, a copy of which shall be delivered to Indemnitee; (ii) if a Change of Control shall not have occurred, (A) by the Board by a majority vote of a quorum consisting of Disinterested Directors, or (B) if a quorum of the
Board consisting of Disinterested Directors is not obtainable, or even if such quorum is obtainable, if such quorum of Disinterested Directors so directs, either (x) by Independent Counsel in a written opinion to the Board, a copy of which shall be
delivered to Indemnitee, or (y) by the stockholders of the Corporation, as determined by such quorum of Disinterested Directors, or a quorum of the Board, as the case may be; or (iii) as provided in Section 10(b) of this Agreement. If it is so
determined that Indemnitee is entitled to indemnification, payment to Indemnitee shall be made within thirty (30) days after such determination. Indemnitee shall cooperate with the persons or entity making such determination with respect to
Indemnitee’s entitlement to indemnification, including providing to such persons or entity upon request any documentation or information which is not privileged or otherwise protected from disclosure and which is reasonably available to
Indemnitee and reasonably necessary to such determination. Any costs or expenses (including attorneys’ fees and disbursements) incurred by Indemnitee in so cooperating with the persons or entity making such determination shall be borne by the
Corporation (irrespective of the determination as to Indemnitee’s entitlement to indemnification) and the Corporation hereby indemnifies and agrees to hold Indemnitee harmless therefrom. 
  

 4 

 (c) If required, Independent Counsel shall be selected as follows: (i) if a Change of Control shall not
have occurred, Independent Counsel shall be selected by the Board by a majority vote of a quorum consisting of Disinterested Directors and the Corporation shall give written notice to Indemnitee advising Indemnitee of the identity of Independent
Counsel so selected; or (ii) if a Change of Control shall have occurred, Independent Counsel shall be selected by Indemnitee (unless Indemnitee shall request that such selection be made by the Board, in which event (i) shall apply), and Indemnitee
shall give written notice to the Corporation advising it of the identity of Independent Counsel so selected. In either event, Indemnitee or the Corporation, as the case may be, may, within seven (7) days after such written notice of selection shall
have been given, deliver to the Corporation or to Indemnitee, as the case may be, a written objection to such selection. Such objection may be asserted only on the ground that Independent Counsel so selected does not meet the requirements of
“Independent Counsel” as defined in Section 1 of this Agreement, and the objection shall set forth with particularity the factual basis of such assertion. If such written objection is made, Independent Counsel so selected may not serve as
Independent Counsel unless and until a court has determined that such objection is without merit. If, within twenty (20) days after submission by Indemnitee of a written request for indemnification pursuant to Section 9(a) hereof, no Independent
Counsel shall have been selected and not objected to, either the Corporation or Indemnitee may petition the Court of Chancery of the State of Delaware, or any court in the State of New Jersey in which such petition would be cognizable, for
resolution of any objection which shall have been made by the Corporation or Indemnitee to the other’s selection of Independent Counsel and/or for the appointment as Independent Counsel of a person selected by such court or by such other person
as such court shall designate, and the person with respect to whom an objection is so resolved or the person so appointed shall act as Independent Counsel under Section 9(b) hereof. The Corporation shall pay any and all reasonable fees and expenses
incurred by such Independent Counsel in connection with its actions pursuant to this Agreement, and the Corporation shall pay all reasonable fees and expenses incident to the procedures of this Section 9(c) regardless of the manner in which such
Independent Counsel was selected or appointed. Upon the due commencement date of any judicial proceeding pursuant to Section 11(a)(iii) of this Agreement, Independent Counsel shall be discharged and relieved of any further responsibility in such
capacity (subject to the applicable standards of professional conduct then prevailing). 
  
 Section 10. Presumptions and Effects of Certain Proceedings. 
  
 (a) If a Change in Control shall have occurred, in making a determination with respect to entitlement to indemnification hereunder, the person or persons or entity making such determination shall presume that
Indemnitee is entitled to indemnification under this Agreement if Indemnitee has submitted a request for indemnification in accordance with Section 9(a) of this Agreement, and the Corporation shall have the burden of proof to overcome that
presumption in connection with the making by any person, persons or entity of any determination contrary to that presumption. 
  
 (b) The person or entity empowered or selected under Section 8 of this Agreement shall make the determination of whether Indemnitee is entitled to
indemnification as soon as practicable after receipt by the Corporation of the request therefore. 
  

 5 

 (c) The termination of any Proceeding or of any claim, issue or matter therein, by judgment, order,
settlement or conviction, or upon a plea of nolo contendere or its equivalent, shall not (except as otherwise expressly provided in this Agreement) of itself adversely affect the right of Indemnitee to indemnification or create a presumption
that Indemnitee did not act in good faith and in a manner which Indemnitee reasonably believed to be in or not opposed to the best interests of the Corporation or, with respect to any criminal Proceeding, that Indemnitee had reasonable cause to
believe that Indemnitee’s conduct was unlawful. 
  
 Section 11.
Remedies of Indemnitee. 
  
 (a) In the event that (i) a
determination is made pursuant to Section 9 or 10 of this Agreement that Indemnitee is not entitled to indemnification under this Agreement, (ii) advancement of Expenses is not timely made pursuant to Section 8 of this Agreement, (iii) the
determination of entitlement to indemnification is made by Independent Counsel pursuant to Section 9 of this Agreement and such determination shall not have been made and delivered in a written opinion within ninety (90) days after receipt by the
Corporation of the request for indemnification, (iv) or (iv) payment of indemnification is not made within thirty (30) days after such determination has been made that Indemnitee is entitled to indemnification or such determination is deemed to have
been made pursuant to Sections 9 or 10 of this Agreement, Indemnitee shall be entitled to an adjudication in an appropriate court of the State of Delaware or the State of New Jersey, of Indemnitee’s entitlement to such indemnification or
advancement of Expenses. Indemnitee shall commence such proceeding seeking an adjudication or an award within one hundred eighty (180) days following the date on which Indemnitee first has the right to commence such proceeding pursuant to this
Section 11(a). 
  
 (b) In the event that a determination shall
have been made pursuant to Section 9 of this Agreement that Indemnitee is not entitled to indemnification, any judicial proceeding commenced pursuant to this Section shall be conducted in all respects as a de novo trial and Indemnitee shall
not be prejudiced by any reason of that adverse determination. If a Change of Control shall have occurred, in any judicial proceeding commenced pursuant to this Section the Corporation shall have the burden of proving that Indemnitee is not entitled
to indemnification or advancement of Expenses, as the case may be. 
  
 (c) If a determination shall have been made or deemed to have been made pursuant to Section 9 or 10 of this Agreement that Indemnitee is entitled to indemnification, the Corporation shall be bound by such determination in any judicial
proceeding commenced pursuant to this Section, absent (i) a misstatement by Indemnitee or Indemnitee’s representative of a material fact, or an omission of any material fact necessary to make Indemnitee’s or Indemnitee’s
representative’s statement not materially misleading, in connection with the request for indemnification, or (ii) prohibition of such indemnification under applicable law. 
  
 (d) The Corporation shall be precluded from asserting in any judicial proceeding commenced pursuant to this Section that the
procedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate in any such court that the Corporation is bound by all the provisions of this Agreement. 
  

 6 

 (e) In the event that Indemnitee, pursuant to this Section, seeks a judicial adjudication of
Indemnitee’s rights under, or to recover damages for breach of, this Agreement, Indemnitee shall be entitled to recover from the Corporation and shall be indemnified by the Corporation against, any and all expenses (of the kinds described in
the definition of Expenses) actually and reasonably incurred by Indemnitee in such judicial adjudication, but only if Indemnitee prevails therein. If it shall be determined that Indemnitee is entitled to receive part but not all of the
indemnification or advancement of expenses sought, the expenses incurred by Indemnitee in connection with such judicial adjudication shall be appropriately prorated. 
  
 Section 12. Non-Exclusivity; Survival of Rights; Insurance Subrogation. 
  
 (a) The rights of indemnification and to receive advancement of Expenses as
provided by this Agreement shall not be deemed exclusive of any other rights to which Indemnitee may at any time be entitled under applicable law, the certificate of incorporation or by-laws of the Corporation, any agreement, a vote of stockholders
or resolution of directors or otherwise. No amendment, alteration or repeal of this Agreement or any provision hereof shall be effective as to any Indemnitee with respect to any action taken or omitted by such Indemnitee in Indemnitee’s
employment or service as an officer or director prior to such amendment, alteration or repeal. 
  
 (b) To the extent that the corporation maintains an insurance policy or policies providing liability insurance for directors, officers, employees, agents or fiduciaries of the corporation or of any other corporation,
partnership, joint venture, trust, employee benefit plan or other enterprise which such person serves at the request of the Corporation, Indemnitee shall be covered by such policy or policies in accordance with its or their terms to the maximum
extent of the coverage available for any such director, officer, employee, agent or fiduciary under such policy or policies. 
  
 (c) In the event of any payment under this Agreement, the Corporation shall be subrogated to the extent of such payment to all of the rights of recovery
of Indemnitee who shall execute all papers required and take all action necessary to secure such rights, including execution of such documents as are necessary to enable the Corporation to bring suit to enforce such rights. 
  
 (d) The Corporation shall not be liable under this Agreement to make any
payment of amounts otherwise indemnifiable hereunder if and to the extent that Indemnitee has otherwise actually received such payment under any insurance policy, contract, agreement or otherwise. 
  
 Section 13. Duration of Agreement. 
  
 This Agreement shall continue until and terminate upon the later of: (a) ten
(10) years after the date that Indemnitee shall have ceased to serve as a director, officer, employee, agent or fiduciary of the Corporation or of any other corporation, partnership, joint venture, trust, employee benefit plan or other enterprise
which Indemnitee served at the request of the Corporation; (b) the final termination of all pending Proceedings in respect of which Indemnitee 
  

 7 

 is granted rights of indemnification or advancement of Expenses hereunder and of any proceeding commenced by Indemnitee
pursuant to Section 11 of this Agreement. This Agreement shall be binding upon the Corporation and its successors and assigns and shall inure to the benefit of Indemnitee and Indemnitee’s heirs. 
  
 Section 14. Severability. 
  
 If any provision or provisions of this Agreement shall be held to be
invalid, illegal or unenforceable for any reason whatsoever: (a) the validity, legality and enforceability of the remaining provisions of this Agreement (including, without limitation, each portion of any Section of this Agreement containing any
such provision held to be invalid, illegal or unenforceable, that is not itself invalid, illegal unenforceable) shall not in any way be affected or impaired thereby; and (b) to the fullest extent possible, the provisions of this Agreement
(including, without limitation, each portion of any Section of this Agreement containing any such provision held to be invalid, illegal or unenforceable, that is not itself invalid, illegal or unenforceable) shall be construed so as to give effect
to the intent manifested by the provision held invalid, illegal or unenforceable. 
  
 Section 15. Exception to Right of Indemnification or Advancement of Expenses. 
  
 Except as provided in Section 11(e), Indemnitee shall not be entitled to indemnification or advancement of Expenses under this Agreement with respect to
any Proceeding, or any claim therein, brought or made by Indemnitee against the Corporation. For the purposes of this Section 15, a Proceeding in the right of the Corporation shall not be deemed to constitute a Proceeding brought or made by the
Corporation. 
  
 Section 16. Identical Counterparts. 
  
 This Agreement may be executed in one or more counterparts, each of which
shall for all purposes be deemed to be an original but all of which together shall constitute one and the same Agreement. Only one such counterpart signed by the party against whom enforceability is sought needs to be produced to evidence the
existence of this Agreement. 
  
 Section 17. Headings. 

 
 The headings of the paragraphs of this Agreement are inserted for
convenience only and shall not be deemed to constitute part of this Agreement or to affect the construction thereof. 
  
 Section 18. Modification and Waiver. 
  
 No supplement, modification or amendment to this Agreement shall be binding unless executed in writing by both of the parties hereto. No waiver of any of
the provisions of this Agreement shall be deemed or shall constitute a waiver of any other provisions hereof (whether or not similar) nor shall such waiver constitute a continuing waiver. 
  

 8 

 Section 19. Notice by Indemnitee. 
  
 Indemnitee agrees promptly to notify the Corporation in writing upon being served with any summons, citation, subpoena,
complaint, indictment, information or other document relating to any Proceeding or matter which may be subject to indemnification or advancement of Expenses covered hereunder. 
  

									
	 	 	 	 	 	 	 COLUMBIA LABORATORIES, INC.

					
	 	 	  

	 	 	 	 By:
	 	  

	 	 	                     , Indemnitee
	 	 	 	 	 	 Name:

	 	 	 	 	 	 	 	 	 Title:

  
 I, [name], [title], certify that the
Board of Directors has authorized the Corporation to enter into this Agreement by a resolution unanimously passed at its [date] meeting. 
  

			
	  

	 Name:

	 Title:

  

 9

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