Document:

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                                                                    EXHIBIT 10.2
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NON-EXCLUSIVE LICENSE AGREEMENT
PAGE 1

ORCHID BIOSCIENCES, INC. HAS REQUESTED THAT THE MARKED PORTIONS OF THIS DOCUMENT
BE ACCORDED 406 CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 UNDER THE SECURITIES
ACT, AS AMENDED.

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

                        NON-EXCLUSIVE LICENSE AGREEMENT

     Effective June 12, 2000 (the "Effective Date"), Orchid BioSciences, Inc., a
Delaware corporation having a principal place of business at 303 College Road
East, Princeton, NJ 08540 (hereafter "Orchid"), and Amersham Pharmacia Biotech,
Inc., a Delaware corporation having a principal place of business at 800
Centennial Ave. Piscataway, NJ 08855 (hereafter "LICENSEE") agree as follows:

     WHEREAS, Orchid owns patents relating to Primer Extension regarding
detection of single nucleotide polymorphisms; and

     WHEREAS, LICENSEE desires to take a non-exclusive license to said patents
relating to the Primer Extension;

     WHEREAS, Orchid is willing to grant to LICENSEE a royalty-bearing,
nonexclusive license under said patents relating to Primer Extension under the
following terms;

     NOW, THEREFORE, the parties agree as follows:

                            ARTICLE I - DEFINITIONS

1.1  "Approved Instruments" mean instruments used for gel electrophoretic
     separation for nucleotide analysis that are approved by Orchid for the
     purposes of this license. [*]

1.2  "End User" means any Third Party licensed to use a Licensed Product
     pursuant to an End User License received in connection with the purchase by
     such Third Party of a Licensed Product.

1.3  "End User License" means a limited non-transferable license in form and
     substance as set forth in Appendix A, granted by Orchid to End Users to use
     only the material included in the Licensed Product in the Licensed Field to
     perform the specified number of Genotypes specified in the literature
     (packaging, product inserts, catalog listings, promotional items, etc)
     supplied by LICENSEE with each unit of Licensed Product.

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

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NON-EXCLUSIVE LICENSE AGREEMENT
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1.4  "Genotype" means the detection or quantification of an individual SNP
     within a single sample.

1.5  "Kit" means a product designed for performing Primer Extension comprising
     one or more Reagents, the sale or offer for sale of which, without the
     licenses granted herein, would infringe or contribute to the infringement
     of at least one claim of a Licensed Patent.

1.6  "Licensed Field" means the use of a Licensed Product on an Approved
     Instrument for Research Purposes only.

1.7  "Licensed Product" means a Kit  and an End User License.

1.8  "Licensed Patents" means US Patent No. 5,888,819 and 6,004,744 and any
     divisionals, continuations, reissues, and foreign counterparts thereof.  To
     date foreign patents include the Australian Patent No. 660,173.

1.9  "Primer Extension" means a nucleic acid template-dependent primer
     extension reaction to determine the identity of a single nucleotide base at
     a specific position in a nucleic acid of interest in which the reaction is
     performed in the presence of two or more terminators and in the absence of
     extendible nucleotide

1.10 "Reagent" means an enzyme, buffer, primer extension chain-terminating
     compound or other composition useful for Primer Extension.

1.11 "Related Company" means (a) any entity that, or an individual who, owns at
     least a 20% interest in LICENSEE by stock ownership or otherwise; (b) any
     entity in which LICENSEE owns at least a 20% interest by stock ownership or
     otherwise; or (c) any entity in which at least a 20% interest by stock
     ownership or otherwise is owned by any entity that, or an individual who,
     also owns at least at 20% interest in LICENSEE by stock ownership or
     otherwise.

1.12 Bona Fide Collaboration means a substantive research and/or development
     collaboration or agreement between an End-User and any Third Party which
     includes the ability for End-User to obtain samples from and share data
     with such Third Parties.  For the avoidance of doubt, End-Users shall not
     be allowed to charge such collaborators on a fee for service basis or
     perform genotyping services for such collaborators.

1.13 "Research Purposes" means the detection and analysis of SNPs in samples
     for research and development purposes only, either alone or in Bona Fide
     Collaborations with one or more Third Parties, and specifically excludes
     performing services for a Third Party, and further excludes any and all
     diagnostic or therapeutic uses.

1.14  "Sales Price" means the most recent list price of LICENSEE's United States
      list

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NON-EXCLUSIVE LICENSE AGREEMENT
PAGE 3

      price for a single unit of a Licensed Product, as set forth in the most
      recent LICENSEE catalogs or such other documentation as may be employed by
      Licensee (and provided by LICENSEE to Orchid from time to time), and, in
      the case that LICENSEE grants a discount on the Sales Price to an End
      User, then the Sales Price used to calculate the Royalty due under Section
      3 shall not be reduced more than [*] of the list price.

1.15  "SNP" means single nucleotide polymorphism.

1.16  "Third Party" means any person or entity other than Orchid and LICENSEE.

1.17  "Third Party Licensee" means any Third Party that has a valid license from
      Orchid to use Kits for purposes other than Research Purposes, as confirmed
      by Orchid pursuant to Section 2.2.

1.18  "Territory" means the entire world.

                           ARTICLE II - LICENSE GRANT

2.1   Non-exclusive License Grant. Orchid hereby grants to LICENSEE under the
      Licensed Patents a non-exclusive license, without the right to grant
      sublicenses, to research and develop, to make, have made (with prior
      notification to Orchid), sell, offer for sale or otherwise dispose of
      Licensed Products in the Territory solely for use in the Licensed Field.
      Under this license, LICENSEE may use the Licensed Product only to the
      extent necessary to perform research and development on Licensed Products
      for sale hereunder and/or quality control functions on lots of the
      Licensed Products, but under no circumstances may LICENSEE use the
      Licensed Products for Research Purposes or for any other purpose within or
      outside the Licensed Field.

2.2   Additional Limited License Grant.

      2.2.1  Orchid additionally grants to LICENSEE, under the Licensed Patents,
             a non-exclusive license, without the right to grant sublicenses, to
             research and develop, to make, have made (with prior notification
             to Orchid), sell, offer for sale or otherwise dispose of Kits in
             the Territory to a Third Party Licensee for use in the Licensed
             Field or otherwise consistent with such Third Party Licensee's
             license from Orchid. Under this license, LICENSEE may use the Kits
             only to the extent necessary for LICENSEE to perform research and
             development on Kits for sale hereunder and/or quality control
             functions on lots of the Kits, but under no circumstances may
             LICENSEE use the Kits for Research Purposes or for any other
             purpose within or outside the License Field.

     2.2.2   Prior to the promotion, sale, offer to sell or any other marketing
             activity by LICENSEE of a Kit to such Third Party Licensee,
             LICENSEE will have

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

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NON-EXCLUSIVE LICENSE AGREEMENT
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             requested and received from Orchid a written confirmation that such
             Third Party is, in fact, a Third Party Licensee pursuant to Section
             1.16. The validity and effectiveness of the license granted under
             Section 2.2.1 is subject to LICENSEE's compliance with Section
             2.2.2.

     2.2.3   Notwithstanding anything herein to the contrary, LICENSEE may
             recommend that its customers contact Orchid directly to explore the
             possibility of becoming Third Party Licensees.

     2.2.4   In all cases, LICENSEE will pay royalties pursuant to Section 3.2
             for all sales of Kits to Third Party Licensees. In all cases Orchid
             shall use reasonable efforts to cause Third Party Licensees to
             purchase Kits only from a licensed provider under similar terms.

2.3  Labeling.  LICENSEE shall label the Licensed Products sold hereunder in
     accordance with Article VI.  It is expressly understood, however, that
     LICENSEE has no responsibility to police its customers or otherwise ensure
     their compliance with the terms of the license granted hereunder.  All such
     policing and enforcement efforts shall be the responsibility of Orchid.

                   ARTICLE III - FEES, ROYALTIES, AND REPORTS

3.1  License Fee. Within twenty-one (21) days of the Effective Date of this
     Agreement, LICENSEE will pay to Orchid a License Fee of [*]

     3.1.1   [*]

3.2  Royalties. LICENSEE will pay Orchid a royalty of [*] of the Sales Price of
     all Licensed Products sold or otherwise disposed of.

     3.2.1   For purposes of this Article 3, the phrase "otherwise disposed of"
             as used in conjunction with a Licensed Product or Kit means (a) any
             Licensed Product or Kit not sold but delivered by LICENSEE to a
             Third Party regardless of the compensation paid to LICENSEE, if
             any.

     3.2.2   A Licensed Product or Kit will be considered sold on the date it is
             shipped or the date invoiced whichever is earlier. A Licensed
             Product or Kit will be considered otherwise disposed of on the date
             shipped. Only one Royalty Fee will be due for each Licensed Product
             or Kit.

3.3  Reports.  Within thirty (30) days after March 31, June 30, September 30,
     and

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

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NON-EXCLUSIVE LICENSE AGREEMENT
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     December 31 of each calendar year, LICENSEE will send to Orchid a
     written report setting forth the Licensed Products and Kits, and the
     Genotypes enabled thereby, sold or otherwise disposed of during the
     preceding three months.  The first such report will include all Licensed
     Products and Kits sold or otherwise disposed of since the Effective Date.
     A report will be sent to Orchid even when no Licensed Products or Kits were
     sold or otherwise disposed of during the period subject to the report.
     Each such report will be accompanied by payment of the Royalties due
     pursuant to Section 3.2 hereof.  A final report will be sent to Orchid
     within sixty (60) days after termination or expiration of this Agreement
     specifying Licensed Products and Kits sold or otherwise disposed of since
     the immediately preceding report and Licensed Products made but not sold or
     otherwise disposed of as of the date of termination or expiration, and
     payment for all such Licensed Products and Kits will accompany the final
     report.

3.4  Records.  LICENSEE will keep good and accurate books of account sufficient
     to permit determination of the Royalties due hereunder and will make such
     books of account available for inspection by an independent auditor, who
     shall be a Certified Public Accountant, designated by Orchid and reasonably
     acceptable to LICENSEE.  Such inspections will be no more frequent than
     once each calendar year during the term hereof and once within six months
     after termination of this Agreement.  The designated auditor will retain in
     confidence the information in the books of account and will report to
     Orchid only the accuracy or inaccuracy of the reports rendered pursuant to
     Section 3.3 hereof.  Such inspections will be at Orchid's expense unless
     the designated accountant identifies underpayment of Royalties due to
     Orchid by five percent (5%) or more, in which event LICENSEE will pay for
     such inspection.  Orchid's failure to inspect will not constitute a waiver
     of Orchid's right to object to the accuracy of the reports rendered or
     payments made under this Agreement.

                       ARTICLE IV - TERM AND TERMINATION

4.1  Term. The term of this agreement begins on the Effective Date and will
     expire on the last day of the last to expire Licensed Patents.

4.2  Termination for Breach.  Either party may terminate this Agreement for a
     material breach of the provisions of this Agreement.  Such termination will
     be effective if the breach has not been cured in fourteen (14) days, if
     breach is for failure to make any payment (other than payment of the
     License Fee), or in sixty (60) days, if the breach is for any other reason,
     after written notice of said breach.

4.3  Surviving Rights.  In the event of termination of this Agreement, LICENSEE
     will have the right to complete all contracts for the sale or disposition
     of Licensed Products or Kits under which LICENSEE is obligated on the date
     of termination provided LICENSEE pays the associated Royalties on such
     sales or dispositions as required in Article III hereof and provided all
     such sales or dispositions are

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NON-EXCLUSIVE LICENSE AGREEMENT
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     completed within three (3) months after the date of termination.

4.4  Remedies.  The right of either party to terminate under the provisions of
     this Article will not be an exclusive remedy, and either party will be
     entitled, if the circumstances warrant, alternatively or cumulatively, to
     damages for breach of this Agreement, to an order requiring performance of
     the obligations of this Agreement, or to any other legally available
     remedy.

             ARTICLE V - FURTHER LICENSES AND TECHNICAL ASSISTANCE

5.1  No Implied License. The license granted herein is limited to the Licensed
     Patents in the Licensed Field, and under this Agreement no license is
     granted under any other patent or technology now or hereafter owned by
     Orchid for practice in the Licensed Field or any other purpose, other than
     the limited license granted by Orchid to LICENSEE with respect to Third
     Party Licensees pursuant to Section 2.2.

5.2  Technical Information.  Orchid has no obligation to provide to LICENSEE
     with any manufacturing or technical information or any other technical
     assistance regarding the Licensed Products or Kits.

                              ARTICLE VI - MARKING

6.1  Patent Marking.  LICENSEE will prominently display on all Licensed Products
     and Kits on a visible surface thereof or, if impractical, on tags, labels,
     manuals, and other materials with which Licensed Products and Kits are
     sold, with the applicable numbers of the Licensed Patents under applicable
     law to enable the patent rights to be enforced to their full extent in any
     country where the Licensed Products or Kits are made, used or sold.

6.2  License Marking.

     6.2.1  LICENSEE will prominently display on the outside of each unit of
            Licensed Product (1) an End User License; (2) a label license
            limiting the use of the Licensed Products to a specified number of
            Genotypes; (3) a label license indicating that the Licensed Product
            may not be used outside the Field; and (4) the fact that U.S. Patent
            Nos. 5,888,819 and 6,004,704 and their foreign counterparts are
            owned by Orchid BioSciences, Inc.

     6.2.2  LICENSEE will prominently display on each Kit (1) a label license
            indicating that the Kit may not be used outside the field for which
            the Third Party has a license from Orchid; and (2) the fact that
            U.S. Patent Nos. 5,888,819 and 6,004,704 and their foreign
            counterparts are owned by Orchid BioSciences, Inc.

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NON-EXCLUSIVE LICENSE AGREEMENT
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                            ARTICLE VII - ASSIGNMENT

7.1  LICENSEE Assignment.  This Agreement has been entered into by Orchid in
     reliance on the particular qualifications of LICENSEE and is personal to
     LICENSEE.  Neither this Agreement nor any rights or obligations hereunder
     may be assigned, pledged, or encumbered by LICENSEE without the express
     prior written approval of Orchid.

                           ARTICLE VIII- INFRINGEMENT

8.1  Infringement.  LICENSEE will use reasonable efforts to promptly notify
     Orchid of any Third Party LICENSEE believes may be infringing a Licensed
     Patent and will, to the greatest extent possible, provide to Orchid any
     information LICENSEE has in support of such belief.  Orchid will have the
     right, but not the obligation, to use such information in an infringement
     action against such Third Party. LICENSEE agrees to cooperate with Orchid
     in any action for infringement of a Licensed Patent brought by Orchid, and
     Orchid will reimburse LICENSEE for all reasonable costs incurred by it in
     providing cooperation requested by Orchid.

           ARTICLE IX - PRODUCT SPECIFICATIONS & LITERATURE REPORTING

9.1  Copies of Literature. LICENSEE will provide Orchid with copies of product
     specification sheets, product inserts, user manuals, user bulletins, and
     user product updates and any other customer materials such as copies of web
     pages or other electronic information relating to Licensed Products and
     Kits at least 10 (ten) days prior to the public release of such
     information.  The copies of such customer materials provided to Orchid need
     not be identical to the customer materials supplied to customers and the
     public, provided the material supplied to Orchid by LICENSEE is
     substantially the same as the actual customer materials with respect to (1)
     the markings required by Article VI of this agreement, (2) the suggested
     uses for the Licensed Products and Kits, and (3) the number of Genotypes
     enabled by Licensed Products and Kits.

9.2  Promotion.  LICENSEE agrees that it will not promote by any means the
     Licensed Products or Kits to any Third Party in contradiction to the End
     User License, except in the single situation permitted by Section 2.2.3 in
     the case of Kits.

     [*]

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

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NON-EXCLUSIVE LICENSE AGREEMENT
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                   ARTICLE XI - REPRESENTATIONS & WARRANTIES

11.1 No Representations.  Nothing in this Agreement will be construed as:

     11.1.1  A warranty or representation by Orchid as to the validity or scope
             of any Licensed Patent;

     11.1.2  A warranty or representation by Orchid that anything made, used,
             sold, or otherwise disposed of under the license granted in this
             Agreement will not infringe patents of third parties;

     11.1.3  A requirement that Orchid will file any patent application, secure
             any patent, or maintain any patent in force; or

     11.1.4  An obligation of Orchid to bring or prosecute actions or suits
             against third parties for infringement of any patent; or

11.2  Orchid Authority. Orchid warrants and represents that it has the full
      right and power to make promises and grant the licenses and covenants set
      forth in this Agreement and that there are no outstanding agreements,
      assignments, or encumbrances inconsistent with the provisions of this
      Agreement.

11.3  LICENSEE Authority. LICENSEE warrants and represents that it has the full
      right and power to make promises and grant the licenses and covenants set
      forth in this Agreement and that there are no outstanding agreements,
      assignments, or encumbrances inconsistent with the provisions of this
      Agreement.

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NON-EXCLUSIVE LICENSE AGREEMENT
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11.4  Disclaimer. EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT, ORCHID MAKES
      NO OTHER REPRESENTATION OR WARRANTY OF ANY KIND, EITHER EXPRESSED OR
      IMPLIED, INCLUDING WARRANTIES AS TO MERCHANTABILITY OR FITNESS FOR A
      PARTICULAR PURPOSE.

                         ARTICLE XII - INDEMNIFICATION

12.1  LICENSEE Indemnification. LICENSEE agrees to indemnify, defend and hold
      harmless Orchid, its subsidiaries or affiliates, their agents, directors,
      officers, employees and assigns ("Orchid Indemnitees"), from and against
      all losses, liabilities, damages, demands and expenses (including
      reasonable attorneys' fees and expenses) arising out of (i) the negligent
      actions of LICENSEE, its employees or any third party acting on behalf of
      or under authority of LICENSEE in the performance of this Agreement, (ii)
      any representation or warranty of LICENSEE in this Agreement; (iii) any
      sale or use by LICENSEE of a Licensed Product or Kit; (iv) any use of a
      Licensed Product by an End User; and (v) any use of a Kit by a Third Party
      Licensee.

12.2  Limitation of Liability. NEITHER PARTY WILL BE LIABLE FOR ANY INCIDENTAL,
      SPECIAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE LICENSE GRANTED
      PURSUANT TO THIS AGREEMENT OR FROM THE USE OR COMMERCIAL DEVELOPMENT OF
      THE LICENSED PRODUCT OR KIT.

                          ARTICLE XIII - MISCELLANEOUS

13.1  Entire Agreement. This Agreement constitutes the entire agreement and
      understanding of the parties with regard to the subject matter hereof and
      merges and supersedes all prior discussions, negotiations, understandings,
      and agreements between the parties concerning the subject matter hereof.
      Neither party will be bound by any definition, condition, warranty, right,
      duty, or covenant other than as expressly stated in this Agreement or as
      subsequently set forth in a written document signed by both parties.

13.2  Choice of Laws. This Agreement will be interpreted and construed, and the
      legal relations created herein will be determined, in accordance with the
      laws of the State of California (excluding conflicts of laws) and of the
      United States.

13.3  Press Releases. The press release attached as Appendix B may be released
      on the Effective Date of this agreement. Otherwise, no press releases
      about this Agreement may be made without the mutual written consent of
      both LICENSEE and Orchid.

13.4  Notices. Any and all notices or other communications required or permitted
      by this Agreement or by law to be served on or given to either party
      hereto by the

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NON-EXCLUSIVE LICENSE AGREEMENT
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      other party will be in writing and delivered or sent to the addresses
      specified in the preamble of this Agreement. Each party may change its
      address for purposes of this Agreement by written notice to the other
      party. All notices or other communications will be deemed duly served and
      given on the date when personally delivered to the party to whom it is
      directed, when transmitted electronically by telex or facsimile, or when
      deposited for delivery in an expedited service such as Federal Express,
      DHL, and the like.

13.5  Confidentiality.  Neither party may disclose the terms of this Agreement
      to any Third Party without the prior written consent to the other party.

13.6  Headings. The headings used in this Agreement are for convenience of
      reference only and are not intended to be a part of or to affect the
      meaning or interpretation of this Agreement.

13.7  Amendment.  No amendment or modification hereof shall be valid or binding
      upon the parties unless made in writing and signed by both parties.

13.8  Force Majeure. Any delays in performance by any party under this Agreement
      (other than the payment of monies due) shall not be considered a breach of
      this Agreement if and to the extent caused by occurrences beyond the
      reasonable control of the party affected, including but not limited to,
      acts of God, embargoes, governmental restrictions, strikes or other
      concerted acts of workers, fire, flood, explosion, riots, wars, civil
      disorder, rebellion or sabotage. The party suffering such occurrence shall
      immediately notify the other party and any time for performance hereunder
      shall be extended by the actual time of delay caused by the occurrence.

13.9  Independent Contractors. In making and performing this Agreement, Orchid
      and LICENSEE act and shall act at all times as independent contractors and
      nothing contained in this Agreement shall be construed or implied to
      create an agency, partnership or employer and employee relationship
      between Orchid and LICENSEE. At no time shall one party make commitments
      or incur any charges or expenses for or in the name of the other party
      except as specifically provided herein.

13.10 Severability. If any term, condition or provision of this Agreement is
      held to be unenforceable for any reason, it shall, if possible, be
      interpreted rather than voided, in order to achieve the intent of the
      parties to this Agreement to the extent possible. In any event, all other
      terms, conditions and provisions of this Agreement shall be deemed valid
      and enforceable to the full extent.

13.11 Waiver. None of the terms, covenants, and conditions of this Agreement can
      be waived except by the written consent of the party waiving compliance.

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NON-EXCLUSIVE LICENSE AGREEMENT
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     IN WITNESS WHEREOF, duly authorized officers of Orchid and LICENSEE have
executed this Agreement in duplicate on the signature page hereof.

Orchid Biosciences, Inc.
     AMERSHAM PHARMACIA BIOTECH, INC.

/s/ Donald R. Marvin                   Name  /s/ Peter B. Loggins
-----------------------------                ----------------------------
Name                                         Name

SVP, COO & CFO                               VP Drug Discovery
-----------------------------                ----------------------------
Title                                        Title

June 12, 2000                                June 7, 2000
-----------------------------                ----------------------------
Date                                         Date

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                                   APPENDIX A

                                END USER LICENSE

"The purchase price of this product includes a limited, non-transferable license
under U.S. Patent Nos. 5,888,819, 6,004,744 and their foreign counterparts owned
by Orchid BioSciences, Inc. of Princeton, New Jersey, to perform only the number
of Genotypes listed on the packaging for this product (For purposes of this End
User License, Genotyping means the detection or quantification of an individual
SNP within a single sample.) solely for the detection and analysis of SNPs in
samples for research and development purposes, either alone or in bona fide
research collaborations with one or more third parties,  only and only on an
instrument used for gel electrophoretic separation for nucleotide analysis. This
license specifically excludes performing services for a third party and any and
all diagnostic or therapeutic uses.   Information about purchasing licenses to
practice primer extension technology covered by Orchid BioSciences, Inc. patents
for any other use may be obtained by contacting the Senior Director for Business
Development at Orchid BioSciences, Inc., Princeton, New Jersey, U.S.A., at (609)
750-2200.

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                                  Appendix B

                                 Press Release

                                       13<PAGE>

                                                                   Exhibit 10.3

ORCHID BIOSCIENCES, INC. HAS REQUESTED THAT THE MARKED PORTIONS OF THIS DOCUMENT
BE ACCORDED 406 CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 UNDER THE SECURITIES
ACT, AS AMENDED.

[*]  CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
     COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

            LICENSE AND SUPPLY AGREEMENT FOR AUTOMATED SNP ANALYSIS

     THIS AGREEMENT, dated June 12, 2000 (the "Effective Date"), is between
ORCHID BIOSCIENCES, INC., a corporation organized and existing under the laws of
the State of Delaware, having a principal place of business at 303 College Road
East, Princeton, New Jersey 08543 ("Orchid"), and BRISTOL-MYERS SQUIBB COMPANY,
a corporation organized and existing under the laws of the State of Delaware,
having a principal place of business at Route 206 and Province Line Road,
Princeton, New Jersey 08543-4000 ("CUSTOMER").

     WHEREAS, Orchid develops and /or manufactures SNPstream Instruments(TM),
Software Packages, Consumables and Systems to perform automated SNP analysis;

     WHEREAS, Orchid makes its SNPstream Instruments, Software Packages,
Consumables, and Intellectual Property available for purchase or license both
separately and as part of Systems that provide turnkey ability for performing
automated SNP analysis; and

     WHEREAS, CUSTOMER desires to have Orchid provide it with a turnkey System
for performing automated SNP analysis;

     NOW THEREFORE, the parties agree as follows:

1.  Definitions

     For all purposes of this Agreement, the following terms have the meanings
set forth below:

     1.1  "Affiliate" means any legal entity directly or indirectly controlling,
          controlled by or under common control with a party to this Agreement.
          For purposes of this Agreement, "control" means the direct or indirect
          ownership of more than fifty percent (50%) of the outstanding voting
          securities of the legal entity, or the right to receive more than
          fifty percent (50%) of the profits or earnings of the legal entity, or
          the right to direct the policy decisions of the legal entity.

     1.2  "Analytic Software" means software for the analysis of data generated
          by the SNPstream Instrument.

     1.3  "Assay Data" means all CUSTOMER assay or research plans, methods,
          objectives, results or analyses, DNA sequences, polymorphisms, genes,
          experimental protocols, genotyping results and other information
          relating to CUSTOMER's use of the System.

     1.4  "Authorized Representative" means a company or individual who is
          authorized by Orchid to perform certain limited obligations under this
          Agreement.

     1.5  "Consumables" means SNP Assay Kits and other items listed on Schedule
          1.5 as amended from time to time.

<PAGE>

     1.6  "Improvements" means any and all new and useful processes,
          manufactures, compositions of matter or methods of use, first
          conceived, reduced to practice or developed after the Effective Date,
          and during the term of this Agreement, by CUSTOMER or its employees,
          consultants or contractors.

     1.7  "Intellectual Property" means the patents, patent applications,
          copyrights and Know How relating to SNPstream Instruments, Software
          Packages, Consumables and Systems for performance of SNP-IT, owned by
          or licensed to Orchid.

     1.8  "Know How" means Orchid's non-patented, proprietary information as of
          the Effective Date for performing automated SNP-IT.

     1.9  "Operator's Manual" means the instructional manual and sheets for the
          proper operation and maintenance of the SNPstream Instrument provided
          by Orchid with each SNPstream Instrument as may be amended or
          supplemented by Orchid from time to time.

     1.10 "Operation Software" means the software for the operation of the
          SNPstream Instrument.

     1.11 "SNP Identification Technology" or "SNP-IT" means an assay that
          identifies one and only one base position of a target nucleic acid.

     1.12 "SNPstream Instrument" means the platform for performing automated
          SNP-IT conforming to the Specifications.

     1.13 "SNP Assay Kit" means the GenoPak(TM) preformatted consumable SNP
          assay kits containing validated and quality controlled reagents or
          similar kits for genotyping.

     1.15 "Software Package" means Analytic Software and Operation Software.

     1.16 "Specifications" means the features of the SNPstream Instrument,
          Software Package and Consumables as described on Schedule 1.15.

     1.17 "System" means SNPstream Instrument, Software Package, Consumables,
          and Intellectual Property to perform automated SNP analysis.

     1.18 "Technical Data" means all data and other information relating to the
          accuracy, speed, throughput rates, usage, duration of operations,
          downtime, disruptions in use, ease of use, errors, problems,
          solutions, and all other information regarding the performance of the
          SNPstream Instrument or Software Package, but not including any Assay
          Data.

2.   SNPstream Instrument

     2.1  Supply, Delivery and Assembly of SNPstream Instrument

                                       2
<PAGE>

          2.1.1  Orchid will provide to CUSTOMER, for the term of this
                 Agreement, one SNPstream Instrument pursuant to the terms of
                 attached Schedule 2.1.1 for CUSTOMER to use in the manner
                 specified in this Agreement.

          2.1.2  Orchid will use reasonable commercial efforts to deliver,
                 assemble and install the SNPstream Instrument at the
                 location(s) and on the date(s) designated by CUSTOMER pursuant
                 to Schedule 2.1.1, without charge to CUSTOMER, in accordance
                 with its Standard Terms and Conditions of Delivery and
                 Installation set forth in attached Schedule 2.1.2.

          2.1.3  If the premises of CUSTOMER are not prepared for assembly and
                 installation of the SNPstream Instrument as required by
                 Orchid's Standard Terms and Conditions of Delivery and
                 Installation as of the scheduled assembly and installation
                 date, CUSTOMER will reimburse all reasonable costs and
                 expenses, including travel expenses, incurred by Orchid or its
                 Authorized Representative, in any delay of the assembly or
                 installation resulting therefrom.

     2.2  Training and Support

          2.2.1  Only employees of CUSTOMER who have been trained by Orchid in
                 the proper operation of the SNP Instrument may operate it.
                 Orchid will provide, at no cost to CUSTOMER, reasonable
                 technical training to CUSTOMER's employees on the proper
                 operation of the SNPstream Instrument at CUSTOMER's site or at
                 Orchid's or another site in accordance with its Standard Terms
                 and Conditions of Training set forth in attached Schedule
                 2.2.1. CUSTOMER is solely responsible for the expenses of its
                 employees in connection with such training.

          2.2.2  Orchid will provide, at no cost to CUSTOMER, reasonable
                 technical support to CUSTOMER in its operation of the SNPstream
                 Instrument in accordance with its Standard Terms and Conditions
                 of Support set forth in attached Schedule 2.2.2.

          2.2.3  If CUSTOMER desires training or support in addition to that
                 provided by Orchid under paragraphs 2.2.1 and 2.2.2, CUSTOMER
                 will reimburse Orchid at Orchid's then prevailing rate for such
                 training and support, including the travel and per diem
                 expenses of the employees of Orchid traveling to CUSTOMER's
                 site at CUSTOMER's request, in accordance with CUSTOMER's non-
                 employee travel policy. CUSTOMER is solely responsible for the
                 expenses of its employees in connection with such training or
                 support.

     2.3  Service and Repair

          2.3.1  CUSTOMER will permit Orchid or an Authorized Representative
                 reasonable access during normal business hours to periodically
                 service, repair and inspect the SNPstream Instrument. At
                 CUSTOMER's request,

                                       3
<PAGE>

                 Orchid and/or any such Authorized Representative shall execute
                 a non-disclosure agreement, in form and substance reasonably
                 acceptable to CUSTOMER, prior to being granted such access.
                 CUSTOMER is not authorized to, and agrees not to, service or
                 repair, or to have a third party not authorized by Orchid,
                 service or repair, the SNPstream Instrument.

          2.3.2  Orchid will, at its option, repair or replace any SNPstream
                 Instrument or any component thereof that does not meet
                 Specifications or is otherwise materially defective in
                 materials or workmanship, provided that CUSTOMER has at all
                 times (1) operated and maintained the SNPstream Instrument in
                 full accordance with the Operator's Manual, as same may be
                 amended by Orchid from time to time, (2) used only those
                 Consumables delivered to it by Orchid (or those supplied by
                 CUSTOMER or an authorized third party pursuant to paragraph
                 4.5.3), and (3) has had all service, repair or replacement of a
                 component of the SNPstream Instrument performed by Orchid.

          2.3.3  CUSTOMER is solely responsible for any repair, replacement,
                 loss or damage resulting from (1) any operation or maintenance
                 of the SNPstream Instrument, or any component thereof, not in
                 full accordance with the Operator's Manual, (2) use of any
                 Consumable not delivered to it by Orchid (and not manufactured
                 by CUSTOMER or an authorized third party pursuant to paragraph
                 4.5.3), or (3) service, repair or replacement of a component of
                 the SNPstream Instrument other than by Orchid or an Authorized
                 Representative. CUSTOMER must reimburse Orchid for all costs
                 and expenses resulting from such repair, replacement, loss or
                 damage to Orchid.

     2.4  Records

          2.4.1  CUSTOMER will use reasonable commercial efforts to keep
                 accurate and complete records as to quantity of usage,
                 performance, reliability, and operation of the SNPstream
                 Instrument and other Technical Data, and will periodically make
                 such records and Technical Data available to Orchid; provided,
                 however, that CUSTOMER shall not be required to disclose any
                 Assay Data.

          2.4.2  Orchid is free to use and disclose any Technical Data and other
                 information received from CUSTOMER under this Agreement without
                 any obligation to CUSTOMER.

     2.5  Return of SNPstream Instrument

          At the end of the term of this Agreement, Orchid will remove the
          SNPstream Instrument, without charge to CUSTOMER, in accordance with
          its Standard Terms and Conditions of Removal set forth in attached
          Schedule 2.5.

     2.6  No License

                                       4
<PAGE>

          2.6.1  Orchid retains all right, title, and interests to the SNPstream
                 Instrument and related materials and information provided under
                 this paragraph 2. Acquisition or operation of the SNPstream
                 Instrument does NOT provide any right or license, express or
                 implied, in or to any patent, copyright, trademark, trade
                 secret, or other proprietary right, foreign or domestic, of
                 Orchid or any third party, except to the limited extent
                 necessary for CUSTOMER's operating the System and its
                 components in accordance with the terms of this Agreement.

          2.6.2  CUSTOMER will use the SNPstream Instrument, Software Package,
                 Consumables, and Know How solely for internal research and
                 development use and only for the detection of genetic
                 polymorphisms by SNP-IT and NOT for diagnostic or therapeutic
                 use, or for or on behalf of any third party, except its
                 Affiliates and its bona fide research collaborators.

          2.6.3  The rights provided herein are personal to CUSTOMER and may not
                 be sublicensed or otherwise transferred without the prior
                 express written approval of Orchid.

     2.7  Further Restrictions

          2.7.1  CUSTOMER will not sell or offer for sale, assign, mortgage,
                 pledge, or allow any lien to be created upon the SNPstream
                 Instrument; and will duly and punctually pay all rents, rates,
                 taxes, charges and impositions payable in respect of the
                 premises of CUSTOMER wherein the SNPstream Instrument is
                 situated, subject to CUSTOMER's legal rights to offset, contest
                 and protect same.

          2.7.2  CUSTOMER will not remove, alter, deface or cover any labels,
                 markings, warnings, instructions, icons, serial numbers, model
                 numbers, trademarks, trade names, or logos affixed or applied
                 by Orchid to the SNPstream Instrument.

3.   Software

     3.1  Supply of Software

          3.1.1  Orchid will provide to CUSTOMER, at no cost and on the terms
                 and conditions of this Agreement, one (1) copy of the Software
                 Package for use with and as part of each SNPstream Instrument.

     3.2  Limited License

          3.2.1  Orchid and/or its licensor(s) retains all right, title, and
                 interests to the SNPstream Software Package.

                                       5
<PAGE>

          3.2.2  CUSTOMER agrees to use the Software Package only with and as
                 part of the SNPstream Instrument; such use being limited to the
                 storing, loading, installing, executing or displaying of the
                 Operation Software on a single computer, processor or
                 controller; the storing, loading, installing, executing or
                 displaying of the Analytic Software on the dedicated
                 computer(s) provided by Orchid; and the making of one (1) copy
                 of the Software Package for archival or backup purposes only.

          3.2.3  Additional site licenses for the Analytic Software are
                 available to CUSTOMER and its Affiliates from Orchid on payment
                 of a license fee.

          3.2.4  CUSTOMER will not modify or make derivative works of the
                 Software Package or reverse engineer, disassemble, or decompile
                 any of the Software Package.

          3.2.5  Upon expiration or termination of this Agreement, CUSTOMER must
                 cease use of the Analytic Software and promptly return it and
                 all copies, including any and all copies acquired under
                 paragraph 3.2.3, to Orchid.

          3.2.6  Upon expiration or termination of this Agreement, CUSTOMER must
                 cease use of the Operation Software and promptly return it and
                 all copies to Orchid.

          3.2.7  This paragraph 3 survives any termination or expiration of this
                 Agreement.

4.   Consumables

     4.1  Supply Of Consumables

          4.1.1  During the term of this Agreement, Orchid will sell to
                 CUSTOMER, and CUSTOMER will purchase from Orchid, all of
                 CUSTOMER's requirements of Consumables, except as provided in
                 paragraphs 4.1.3 and 4.5.3.

          4.1.2  CUSTOMER will issue written purchase orders to Orchid for
                 Consumables. The purchase orders are subject to the terms and
                 provisions of this Agreement which, if other or different than
                 those of the purchase order, will be controlling even if the
                 purchase order is accepted and filled by Orchid.

          4.1.3  Orchid will use all commercially reasonable efforts to supply
                 CUSTOMER's reasonable requirements of Consumables. All purchase
                 orders will be accepted unless Orchid notifies CUSTOMER within
                 ten (10) business days of receipt of the purchase order that
                 Orchid cannot fill the purchase order. Unless Orchid notifies
                 CUSTOMER within ten (10) business days after the delivery of
                 any such notice that Orchid is, in fact, able to fill such
                 purchase order, the Minimum Throughput/yr. described

                                       6
<PAGE>

                 in Schedule 2.1.1 shall be reduced in the amount of Consumables
                 Orchid is unable to supply.

          4.1.4  CUSTOMER may defer or cancel delivery of Consumables specified
                 in a purchase order by notifying Orchid at least twenty (20)
                 business days prior to the requested delivery date.

          4.1.5  All permitted cancellations are subject to cancellation charges
                 of ten percent (10%) of the purchase price. A request by
                 CUSTOMER to defer delivery of Consumables for more than sixty
                 (60) days after the date provided on the original invoice will
                 be considered a cancellation for purposes of this paragraph
                 4.1.5.

     4.2  Delivery

          4.2.1  Orchid will use reasonable efforts to deliver to CUSTOMER
                 Consumables on or before the date requested in CUSTOMER's
                 purchase order (but will have no obligation to deliver
                 Consumables in less than thirty (30) business days from receipt
                 of the purchase order). A purchase order can be placed only
                 after conversion of a marker site into a validated genotyping
                 assay, as described in the attached Schedule 1.15.

          4.2.2  Orchid will ship Consumables F.O.B. Orchid's manufacturing
                 plant, or its supplier's plant, freight prepaid, to the address
                 specified in CUSTOMER's purchase order. CUSTOMER will be
                 invoiced for all shipping charges, freight, insurance, special
                 handling (where required) and similar costs, import permits and
                 duties (if applicable) and all taxes assessed. Title and the
                 risk of loss with respect to Consumables will transfer to
                 CUSTOMER at this time. Unless otherwise agreed or specified by
                 CUSTOMER in the applicable purchase order, Orchid may select
                 the carrier or freight forwarder; however, the carrier or
                 freight forwarder must be at all times an agent of CUSTOMER.
                 Orchid will not be liable for any damages, loss or penalty for
                 delay in delivery caused by the carrier or freight forwarder or
                 for failure of the carrier or freight forwarder to give
                 CUSTOMER notice of any delay.

     4.3  Price

          4.3.1  CUSTOMER has selected the price schedule for Consumables
                 indicated on attached Schedule 2.1.1. Therefore, the prices for
                 Consumables to be delivered by Orchid under this Agreement are
                 as CUSTOMER selected on Schedule 2.1.1.

          4.3.2  Subject to the provisions of paragraphs 4.1.3 and 4.5.3, in the
                 event that the quantity of Consumables actually purchased by
                 CUSTOMER in any period is less than the committed quantity,
                 CUSTOMER will pay to Orchid the shortfall fee set forth in
                 CUSTOMER's selected price schedule

                                       7
<PAGE>

                 within thirty (30) days of receipt of Orchid's invoice
                 therefor. Orchid shall be permitted to deliver such invoices
                 only once per year.

          4.3.3  Notwithstanding the provisions of paragraph 4.3.1, Orchid may
                 at any time after one (1) year from the Effective Date of this
                 Agreement, further increase its prices (and amend Schedule
                 2.1.1 accordingly) if  [*]

     4.4  Payment

          4.4.1  Payment of the Access Fee set forth in Schedule 2.2.1 will be
                 made upon the sooner of (i) the tenth (10th) business day after
                 the commissioning and validation of the SNPstream Instrument
                 and completion of the initial training to be provided by Orchid
                 hereunder, or (ii) September 29, 2000; provided, however, that
                 if such commissioning, validation and training are not complete
                 by September 29, 2000 for reasons that are within Orchid's
                 ability to control, then such payment shall be delayed until
                 such commissioning, validation and training are complete. Such
                 payment will be made in United States Dollars, by wire transfer
                 of funds to an account designated by Orchid or by delivery of
                 an irrevocable cashier's check to Orchid. The following is wire
                 transfer information for Orchid's bank:

                 [*]

                 All other payments will be made in United States Dollars and
                 within forty-five (45) days of receipt of Orchid's invoice.

          4.4.2  If payment is not received by the due date, a service charge
                 will be added at the rate of 10% per year or the maximum legal
                 rate, whichever is less, to unpaid invoices from the due date
                 thereof.

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

                                       8
<PAGE>

     4.5  Forecasts and Allocation

          4.5.1  Within thirty (30) days after the Effective Date of this
                 Agreement and at the beginning of each calendar quarter
                 thereafter, CUSTOMER will provide Orchid with a written
                 forecast of its requirements for Consumables for a minimum of
                 the next four (4) calendar quarters. The first calendar quarter
                 of such forecast represents a firm commitment to purchase such
                 Consumables in that quarter (subject to the cancellation and
                 deferral provisions of paragraphs 4.1.4 and 4.1.5). The
                 remaining portion of each forecast represents a non-binding
                 projection on which Orchid will base its material procurement
                 and manufacturing plans.

          4.5.2  In the event that demand for any Consumable should at any time
                 exceed Orchid's capacity to fill and deliver all of its
                 CUSTOMER's orders (and its own need for Consumables), Orchid
                 will notify CUSTOMER of the excess demand. Until such time as
                 the excess demand abates or Orchid's capacity becomes
                 sufficient to meet such demand Orchid will have the right,
                 subject to paragraphs 4.1.3 and 4.5.3, to equitably allocate,
                 in any reasonable manner, its available supplies, manufacturing
                 capacity, inventory and other resources, among CUSTOMER, itself
                 and its other customers, including those not then under
                 contract.

          4.5.3  Further to paragraph 4.5.2, in the event Orchid is unable, or
                 expects to be unable, to reasonably supply CUSTOMER 's total
                 requirements of Consumables for  [*]  consecutive business
                 days, CUSTOMER may self-supply or obtain from any other source,
                 reasonably acceptable to Orchid, that portion of its
                 requirements for Consumables which Orchid is unable to
                 reasonably supply for so long as Orchid is unable or expects to
                 be unable to supply such portion of CUSTOMER's requirements.
                 Any such third party alternate source will supply only
                 Consumables that conform to Specifications and are of the same
                 or better quality as those supplied by Orchid. Orchid will
                 provide CUSTOMER with Know How and technical assistance and
                 information as may be reasonably required by CUSTOMER to
                 establish an alternate source of Consumables, including a
                 license under any patent which Orchid has rights to license on
                 the method of manufacture of the Consumables or on the method
                 of use of the Consumables authorized in this Agreement. Any
                 Consumable that, when ordered by CUSTOMER in accordance with
                 the terms of this Agreement, Orchid is unable to supply shall
                 count toward satisfaction of CUSTOMER's Minimum Through-
                 put/year obligation under Schedule 2.1.1.

     4.6  Inspection and Acceptance

          4.6.1  CUSTOMER may conduct acceptance testing upon receipt of
                 Consumables to verify conformance with Specifications. In the
                 absence of written notice to Orchid of nonconformance and
                 nonacceptance within

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

                                       9
<PAGE>

                 thirty (30) business days of delivery, the Consumables will be
                 deemed accepted.

          4.6.2  If Orchid disputes CUSTOMER's notice that a Consumable fails to
                 conform to Specifications, such dispute will be resolved by an
                 independent laboratory, selected by Orchid and reasonably
                 acceptable to CUSTOMER, whose determination will be final and
                 binding, absent manifest error. All fees and disbursements
                 incurred in connection with the independent determination will
                 be borne by the party which incorrectly determined that the
                 Consumable did or did not conform to the Specifications and
                 shall be shared equally by the parties if it is determined that
                 the Consumables conformed in part and failed to conform in
                 part.

          4.6.3  Orchid promptly will replace any Consumable not conforming to
                 the Specifications, at its expense; or, if unable to make
                 prompt replacement, refund any payment made on the
                 nonconforming Consumable. The amount of any nonconforming
                 Consumables that are not replaced within thirty (30) days after
                 final determination of nonconformity shall be deducted from the
                 Minimum Throughput/yr. described in Schedule 2.1.1. CUSTOMER
                 shall not be required to pay for any non-conforming
                 Consumables.

     4.7  Limited License

          4.7.1  Orchid grants to CUSTOMER, for the term of this Agreement, a
                 non-exclusive license to use the Consumables (both those
                 provided under Section 4 and those provided under section 4.5.3
                 hereof) in connection with CUSTOMER's use of the System as
                 provided herein. CUSTOMER acknowledges that Consumables
                 delivered and sold to CUSTOMER are under license from Orchid
                 solely for the uses specified in paragraph 2.6.2. Orchid
                 acknowledges that it has no right to limit, and that no such
                 limitation of use shall apply to, CUSTOMER Assay Data. No other
                 license is intended or granted through sale of Consumables to
                 CUSTOMER.

          4.7.2  Purchase by CUSTOMER of Consumables does not include or carry
                 any right to resell or transfer Consumables, either as a stand
                 alone product or as a component of another product, or to
                 disassemble and use any component or part of any Consumable
                 separate from its other components and parts, or to otherwise
                 commercially exploit the Consumables. Any use of Consumables
                 other than the licensed use without the prior, express written
                 authorization of Orchid is strictly prohibited.

5.   Warranties

     5.1  Generally

                                       10
<PAGE>

          5.1.1  Orchid warrants that for a period of  [*]  after
                 commissioning and validation hereunder (i) all SNPstream
                 Instruments and all Analytic Software delivered to CUSTOMER
                 shall conform to their respective Specifications, and (ii) all
                 SNPstream Instruments delivered to CUSTOMER shall be free from
                 defects in materials and workmanship. In addition, Orchid
                 warrants that, to the best of its knowledge, the Analytic
                 Software and any media used to distribute same shall contain no
                 computer instructions, circuitry or other technological means
                 the purpose of which is to disrupt, damage or interfere with
                 Customer's use of its computer and telecommunications
                 facilities for Customer's business purposes.

          5.1.2  Orchid warrants that all Consumables, when delivered to
                 CUSTOMER, shall conform to their Specifications and shall be
                 free from defects in materials and workmanship.

          5.1.3  Orchid makes no warranties concerning the Operation Software,
                 which Orchid has licensed and/or otherwise acquired from a
                 third party(ies), but Orchid shall assign to CUSTOMER, and
                 reasonably assist CUSTOMER in recovering under, any
                 manufacturer or vendor warranties that Orchid receives in
                 connection with the Operation Software.

     5.2  THERE ARE NO OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY
          WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE AND
          NONE IS CREATED, WHETHER UNDER THE UNIFORM COMMERCIAL CODE, CUSTOM OR
          USAGE IN THE INDUSTRY OR THE COURSE OF DEALINGS BETWEEN THE PARTIES.

     5.3  ORCHID MAKES NO WARRANTY OR REPRESENTATION TO CUSTOMER THAT USE OF ANY
          SNPSTREAM INSTRUMENT, SOFTWARE PACKAGE, CONSUMABLE, OR KNOW HOW, OR
          ANY PRODUCT PRODUCED BY SUCH USE, WILL NOT INFRINGE ANY PATENT,
          COPYRIGHT, TRADE SECRET, OR OTHER PROPRIETARY RIGHT, FOREIGN OR
          DOMESTIC, OF ANY THIRD PARTY TO WHICH ORCHID HAS NOT OBTAINED RIGHTS.
          NOTWITHSTANDING THE FOREGOING, HOWEVER, ORCHID WARRANTS THAT IT IS NOT
          AWARE OF ANY SUCH INFRINGEMENT AND HAS NOT RECEIVED ANY NOTICE OF
          POSSIBLE INFRINGEMENT.

     5.4  EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT AND THE SCHEDULES
          HERETO, ORCHID DOES NOT WARRANT, GUARANTEE OR MAKE ANY REPRESENTATION
          REGARDING THE USE, OR THE RESULTS OF THE USE, OR THE PERFORMANCE OF
          THE SNPSTREAM INSTRUMENT, SOFTWARE PACKAGE, CONSUMABLE, OR KNOW HOW.
          CUSTOMER REPRESENTS AND WARRANTS THAT ANY STATEMENTS HERETOFORE OR
          HEREAFTER MADE BY ORCHID OR ANY AUTHORIZED REPRESENTATIVE RELATIVE TO
          THE USE, RESULTS OF THE

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

                                       11
<PAGE>

          USE OR PERFORMANCE OF THE SNPSTREAM INSTRUMENT, SOFTWARE PACKAGE,
          CONSUMABLE, OR KNOW HOW WERE AND WILL ALWAYS BE INDEPENDENTLY VERIFIED
          BY CUSTOMER AND CUSTOMER AGREES THAT ITS ACCEPTANCE AND/OR USE OF SUCH
          STATEMENTS IS ENTIRELY AT ITS OWN RISK.

     5.5  EXCEPT AS EXPRESSLY PROVIDED IN PARAGRAPHS 5.1, 5.3 AND 6.1, ORCHID
          WILL NOT BE LIABLE TO CUSTOMER, CUSTOMER'S AFFILIATES, CUSTOMER'S
          SUCCESSORS OR ASSIGNS OR ANY THIRD PARTY WITH RESPECT TO ANY USE OF
          THE SNPSTREAM INSTRUMENT, SOFTWARE PACKAGE, CONSUMABLE, OR KNOW HOW BY
          CUSTOMER OR ANY AGENT OR EMPLOYEE OF CUSTOMER, OR ANY LOSS, CLAIM,
          DAMAGE OR LIABILITY OF ANY KIND OR NATURE WHICH MAY ARISE FROM OR IN
          CONNECTION WITH THE USE, HANDLING, STORAGE, OR DISPOSAL OF THE
          SNPSTREAM INSTRUMENT, SOFTWARE PACKAGE, CONSUMABLE, OR KNOW HOW, OR
          ANY PRODUCTS RESULTING FROM SUCH USE; OR ANY CLAIM FOR LOSS OF
          PROFITS, LOSS OR INTERRUPTION OF BUSINESS, OR FOR INDIRECT, SPECIAL OR
          CONSEQUENTIAL DAMAGES OF ANY KIND.

6.   Indemnification

     6.1  Orchid agrees to indemnify, defend, and hold harmless CUSTOMER, its
          Affiliates and their respective directors, officers, agents,
          employees, representatives and assigns, from and against all
          liabilities, demands, damages, expenses and losses (including
          reasonable attorney fees and costs), arising out of (i) the negligent
          actions or willful misconduct of Orchid, its employees or any third
          party acting on behalf or under authority of Orchid in the performance
          of this Agreement (including, without limitation, any Authorized
          Representative) and (ii) any actual or alleged act of patent
          infringement, contributory patent infringement, inducing patent
          infringement, copyright infringement, or trade secret misappropriation
          resulting from CUSTOMER's use of the SNPstream Instruments, Software
          Package, Consumables, Know How or any information and materials
          received hereunder, in a manner permitted under this Agreement. At any
          time during the course of any action involving a SNPstream Instrument,
          Software Package or Consumable, or if in Orchid's opinion a SNPstream
          Instrument, Software Package or Consumable is likely to become the
          subject of a patent infringement claim, Orchid may at its option and
          expense, (i) procure for CUSTOMER the right to continue using the
          SNPstream Instrument, Software Package or Consumable, (ii) replace or
          modify the SNPstream Instrument, Software Package or Consumable so
          that it becomes noninfringing or (iii) accept return of the SNPstream
          Instrument, Software Package or Consumable, refund the purchase price
          for same and the Access Fee, pro rata from the date CUSTOMER was
          prohibited from using the SNPstream Instrument, Software Package
          and/or Consumables due to such action, and terminate this Agreement.
          In the event Orchid is not successful in its efforts under clause (i)
          and/or (ii) of the preceding

                                       12
<PAGE>

          sentence within three (3) months after any such claim arises, Orchid
          shall, at CUSTOMER's request undertake an action set forth in clause
          (iii).

     6.2  Orchid will not be liable to CUSTOMER under paragraph 6.1 if the
          patent or copyright infringement claim is based on an alteration or
          modification of the SNPstream Instrument, Software Package or
          Consumable or a use of the SNPstream Instrument, Software Package or
          Consumable not authorized by Orchid.

     6.3  CUSTOMER agrees to indemnify, defend and hold harmless Orchid, its
          Affiliates, Authorized Representatives and their respective directors,
          officers, agents, employees, and assigns, from and against all
          liabilities, demands, damages, expenses and losses (including
          reasonable attorney fees and costs) arising out of (i) CUSTOMER's use,
          handling, storage and disposal of each SNPstream Instrument, Software,
          Consumables, Know How and any information and materials received from
          Orchid other than in accordance with Orchid's or its Authorized
          Representative's instructions, except with respect to those resulting
          from Orchid's (or its employees' or agents') negligence or willful
          misconduct, (ii) any products developed or made by CUSTOMER as a
          result of the use of the SNPstream Instrument, Software Package,
          Consumables, Know How and any information and materials received from
          Orchid and (iii) any actual or alleged act of patent infringement,
          contributory patent infringement, inducing patent infringement,
          copyright infringement or trade secret misappropriation resulting from
          CUSTOMER's use of the SNPstream Instruments, Software Package,
          Consumables, Know How and any information and materials received, in
          any manner not  permitted under this Agreement or in CUSTOMER's
          manufacture, use or sale of any product resulting from such use;
          provided, however, that CUSTOMER shall not have any obligation under
          this paragraph 6.3 with respect to any such liabilities, demands,
          damages, expenses or losses to the comparative extent that Orchid has
          an obligation to indemnify CUSTOMER under paragraph 6.1 with respect
          thereto.

     6.4  Any person entitled to and seeking indemnification under this
          Agreement will give prompt written notice to the indemnifying party of
          the commencement of any action (and any prior claims relating to such
          action) for which such person seeks indemnification.  An indemnifying
          party will have no liability or responsibility of any kind to the
          person seeking indemnification if it is not promptly notified and does
          not have adequate opportunity to defend.  The indemnifying party will
          have sole control of the defense of the action and of all negotiations
          for its settlement or compromise, except that the indemnifying party
          shall not agree to any settlement or compromise that adversely affects
          the person being indemnified and/or the other party without the prior
          written consent of such person or other party.  Each indemnified party
          shall cooperate with the indemnifying party under this section 6.

     6.5  This section 6 survives any termination or expiration of this
          Agreement.

                                       13
<PAGE>

7.   Improvements

     7.1  Upon, or before, delivery of CUSTOMER's initial order of Consumables,
          and subject to paragraph 8, Orchid will disclose in confidence to
          CUSTOMER its Know How regarding the ordered Consumables.

     7.2  CUSTOMER hereby assigns to Orchid all CUSTOMER's rights to, and will
          cause its employees, consultants and contractors to assign to Orchid
          all their rights to, any direct Improvements to any of the hardware or
          software comprising, or any biochemical assays used in, the SNPstream
          Instrument, Software Package and Consumables.  Orchid's rights under
          this paragraph 7.2 shall not extend to (i) inventions, discoveries and
          improvements in the field of genetic marker identification generally
          or SNP analysis that are made by CUSTOMER's employees, consultants and
          contractors, or (ii) any Assay Data, all of which shall be owned by
          CUSTOMER exclusively.  This paragraph survives any termination or
          expiration of this Agreement.

     7.3  At any time, whether during the term of this Agreement or after
          termination of this Agreement, Orchid may request CUSTOMER to (and to
          cause its employees, consultants and contractors to) execute,
          acknowledge and deliver all papers, including applications for
          patents, and to perform such other acts as, in the reasonable opinion
          of Orchid, may be necessary or desirable to obtain or maintain patents
          or copyrights or other proprietary rights for the Technical Data and
          Improvements to which Orchid has rights under paragraph 7.2 in any and
          all countries and to vest title thereto in Orchid, its successors,
          assigns or nominees. CUSTOMER agrees to perform these acts without
          charge to Orchid, but at Orchid's expense.  This paragraph survives
          any termination or expiration of this Agreement.

8.   Confidentiality

     8.1  CUSTOMER agrees not to disclose publicly or to any third party, and to
          keep in strictest confidence, all (i) prices and price schedules, (ii)
          Technical Data, (iii) Know How, (iv) Improvements, and (v) all
          information identified by Orchid as being secret or confidential. If
          any information under clause (v) is disclosed in written or electronic
          format, it must be prominently labeled "Confidential," "Proprietary,"
          etc.  If any information under clause (v) is disclosed in visual
          and/or oral format, it must be stated to be confidential at the time
          of disclosure and summarized in a writing sent to CUSTOMER within
          thirty (30) days thereafter.

     8.2  The obligation of confidentiality under this paragraph 8 does not
          apply to information which CUSTOMER can demonstrate is known publicly,
          is in the public domain or enters into the public domain without the
          fault of CUSTOMER, was known to CUSTOMER prior to the Effective Date
          of this Agreement, is disclosed to CUSTOMER by a third party not under
          obligation of confidence, is independently developed by employees or
          agents of CUSTOMER without access

                                       14
<PAGE>

          to, or use of, Orchid's confidential information, or which CUSTOMER is
          required to disclose in order to comply with any applicable law,
          regulation or governmental order.

     8.3  The obligations of this paragraph 8 survive and continue for a period
          of five (5) years after any termination or expiration of this
          Agreement.

9.   Term and Termination

     9.1  This Agreement will expire and terminate at the end of the price
          schedule selected by CUSTOMER on attached Schedule 2.1.1; provided,
          however, that CUSTOMER shall have the right to extend the term of this
          Agreement, for a like period, up to three (3) times, upon notice and
          payment to Orchid at least ninety (90) days in advance of the then
          current expiration date. CUSTOMER shall pay Orchid an annual renewal
          fee in connection with each such extension.  The amount of such
          renewal fee shall be determined by the parties, in good faith, after
          delivery of CUSTOMER's renewal notice and shall be (i) based
          CUSTOMER's past level of usage of Orchid's support and maintenance
          services, and (ii) competitive with renewal fees Orchid is then
          charging other similarly situated customers.  The price of Consumables
          during each successive extension period shall, notwithstanding
          paragraph 4.3.3, decrease by at least  [*].

     9.2  Orchid and CUSTOMER have the right to terminate this Agreement if the
          other fails to make any payment due and owing, or commits a breach of
          any material provision of this Agreement and fails to make such
          payment within thirty (30) days or remedy such breach within sixty
          (60) days after receiving written notice of such default or breach.
          This right of termination, however, cannot be exercised if at any time
          during said time period, the party accused of default or breach cures
          such default or breach or provides proof that such party is not in
          default or has not committed such breach. In such event Orchid and
          CUSTOMER will negotiate in good faith to resolve the disputed payment
          or breach before taking any other action to resolve same.

     9.3  Subject to applicable law (including the U.S. Bankruptcy Code), Orchid
          and CUSTOMER each have the right to terminate this Agreement if any
          proceeding is instituted by or against the other party seeking to
          adjudicate it bankrupt or insolvent, or seeking liquidation, winding
          up, reorganization, arrangement, adjustment, protection, relief or
          composition of it or its debts under any law relating to bankruptcy,
          insolvency or reorganization or relief of debtors, or seeking an entry
          of an order for relief or the appointment of a receiver, trustee or
          other similar official for it or any substantial part of its property
          or taking any action to authorize any of the foregoing or similar
          actions.  No assignee for the benefit of creditors, receiver,
          liquidator, sequestrator, trustee in bankruptcy, sheriff or any other
          officer of the court or official charged with taking over custody of
          CUSTOMER's assets or business will have any right to continue the
          performance of this Agreement.  Notwithstanding any other provision of
          this Agreement, Orchid acknowledges and agrees that this Agreement
          constitutes a

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

                                       15
<PAGE>

          license with respect to the SNPstream Instrument, Software Package,
          Consumables and Know How for the purposes of this paragraph 9.3.

     9.4  In the event this Agreement is terminated by CUSTOMER pursuant to the
          provisions of paragraph 9.2 or 9.3, upon written notice from CUSTOMER,
          Orchid will remove the SNPstream Instrument(s), at no cost to
          CUSTOMER, in accordance with its Standard Terms and Conditions of
          Removal set forth in attached Schedule 2.5.  In addition Orchid shall
          refund to CUSTOMER that portion of the then current Access Fee or
          renewal fee, as the case may be, applicable, on a pro rata basis, to
          the portion of the initial term or any renewal term of this Agreement,
          as the case may be, from and after the effective date of any such
          termination.  This paragraph survives any termination or expiration of
          this Agreement.

     9.5  In the event this Agreement is terminated by Orchid pursuant to the
          provisions of paragraph 9.2 or 9.3, upon written notice to CUSTOMER,
          Orchid may remove the SNPstream Instrument, at CUSTOMER's expense, in
          accordance with its Standard Terms and Conditions of Removal set forth
          in attached Schedule 2.5; and, CUSTOMER will pay to Orchid, within
          thirty (30) days of such termination, the early termination fee set
          forth in the price schedule of attached Schedule 2.1.1. This paragraph
          survives any termination or expiration of this Agreement.

     9.6  Upon expiration or termination of this Agreement for any cause or
          reason neither CUSTOMER nor Orchid will be released from any
          obligation theretofore accrued.  The parties' respective rights and
          obligations under the following provisions shall survive pay
          termination or expiration of this Agreement:  Paragraphs 2.4.2, 2.6.1,
          3.2.1, 3.2.5, 3.2.6, 4.3.3, 4.6, 5, 6, 8, 9.5, 9.6, 9.7, 10.2, 10.3
          and 10.9.

10.  Miscellaneous

     10.1 The relationship of Orchid and CUSTOMER under this Agreement is that
          of both licensor and licensee and seller and buyer. The provisions of
          this Agreement may not be construed to create between Orchid and
          CUSTOMER the relationship of principal and agent, joint venturers, co-
          partners or any other similar relationship, the existence of which is
          hereby denied by Orchid and CUSTOMER. Neither party hereto is liable
          in any way for any engagement, obligation, liability, contract,
          representation or warranty of the other party to or with any third
          party. Orchid is not an agent for CUSTOMER and CUSTOMER is not an
          agent for Orchid for any purpose whatsoever and each party has no
          right or authority to assume or create any obligations, express or
          implied, on behalf or in the name of the other party.

     10.2 Orchid, in its performance of this Agreement, may delegate its
          obligations or duties to one or more Authorized Representatives as
          agent(s) for Orchid under this Agreement.  However, no Authorized
          Representative has the right or authority to make any representation
          or warranty to CUSTOMER, or to assume or

                                       16
<PAGE>

          create any obligations with or for CUSTOMER, whether express or
          implied, on behalf or in the name of Orchid except as expressly set
          forth in this Agreement. Notwithstanding any such delegation, Orchid
          shall remain liable for the performance of such obligations and duties
          and for the performance of any Authorized Representatives to which
          Orchid may delegate performance of same.

     10.3 During the term of this Agreement and for a period of one year
          thereafter, neither Orchid nor CUSTOMER will actively solicit for
          employment any of the other's technical personnel.

     10.4 No waiver of any breach of any provision of this Agreement will
          constitute a waiver of any prior, concurrent or subsequent breach of
          the same or any other provision of this Agreement; and no waiver will
          be effective unless in writing.

     10.5 Any notice required or permitted under this Agreement will be deemed
          to have been sufficiently provided and effectively made if sent by
          facsimile and either hand-delivered or sent by overnight express
          courier (e.g., Federal Express), signature required, and addressed to
          the receiving party at its respective address as follows:

     Orchid Biosciences, Inc.           Bristol-Myers Squibb Company
                                        P.O. Box 4000
     303 College Road East              Route 206 & Province Line Road
     Princeton, NJ  08540               Princeton, NJ  08543-4000
     Facsimile:  (609) 750-2250         Facsimile:  (609) 452-4232
     Attn:  Kevin Nash                  Attn:  Vice-President & Senior Counsel
                                        Pharmaceutical Research Institute and
                                        Worldwide Business Development

     With a courtesy copy to:
     Kalow Springut & Bressler LLP
     488 Madison Avenue
     New York, NY  10016
     Facsimile:  (212) 813-9600
     Attn:  David A. Kalow

           or such other address of which the receiving party has given notice
           pursuant to this paragraph 10.5.  The effective date of the notice is
           the date of receipt of the hand or courier delivery.

     10.6  In the event that the performance of this Agreement or of an
           obligation hereunder, other than the payment of money, is prevented,
           restricted or interfered with by reason of any cause not within the
           control of the respective party, and which could not by reasonable
           diligence have been avoided by such party, the party so affected,
           upon the giving of prompt notice to the other party, as to the nature
           and probable duration of such event, is excused from such performance
           to the extent and for the duration of such prevention, restriction or
           interference, provided that

                                       17
<PAGE>

           the party so affected uses its reasonable efforts to avoid or remove
           such cause of non-performance and continues performance under this
           Agreement whenever and to the extent such cause or causes are
           removed. For the purpose of this paragraph 10.6, but without limiting
           the generality hereof, the following will be considered as not being
           within the control of a party: acts of God; acts or omissions of a
           governmental agency or body; compliance with requests,
           recommendations, rules, regulations, or orders of any governmental
           authority or any officer, department, agency, or instrument thereof;
           flood; storm; earthquake; fire; war; insurrection; riot; accidents;
           acts of the public enemy; invasion; quarantine restrictions; strike;
           labor lockout; differences with workmen; embargoes; delays or
           failures in transportation; and acts of a similar nature.

     10.7  If any provision of this Agreement is held to be invalid, illegal,
           unenforceable or void, such will be without effect on the validity,
           legality and enforceability of the remaining provisions or this
           Agreement as a whole. Both parties will endeavor to replace the
           invalid, illegal, unenforceable or void provision with a valid and
           enforceable one which in its equitable effect is most consistent with
           the prior provision.

     10.8  The paragraph headings are for convenience only and cannot have any
           effect on the interpretation or construction of this Agreement.

     10.9  The laws of the State of New Jersey, excluding the principles of
           conflicts of laws, govern this Agreement.

     10.10 This Agreement is binding upon and inures to the benefit of the
           heirs, successors and assigns of the parties hereto, provided that
           this Agreement, in whole or in part, is not assignable by either
           party without the prior written consent of the other party, such
           consent not to be unreasonably withheld, except that Orchid may
           assign this Agreement to an Affiliate of Orchid without any such
           consent. As a condition precedent to any such permitted assignment,
           the assignee shall agree, in writing, to be bound by the provisions
           of this Agreement applicable to its assignor. Any effort to assign in
           violation hereof is considered void. In the event of any assignment,
           the assigning party must provide the other party with appropriate
           documentation of the assignment.

     10.11 Each party acknowledges that it has read this Agreement, understands
           it, and agrees to be bound by its terms and further agrees that it
           constitutes the complete and exclusive understanding between the
           parties, which supersedes and merges all prior proposals,
           understandings and all other agreements, oral and written, between
           the parties regarding the subject matter of this Agreement; and no
           party has relied on any representation not expressly set forth or
           referred to in this Agreement.

     10.12 No amendment, variation, waiver or modification of any of the terms
           or provisions of this Agreement will be effected unless set forth in
           writing,

                                       18
<PAGE>

           specifically referencing this Agreement, and duly signed by an
           authorized officer of the party to be bound thereby.

     10.13 Except as expressly provided herein, nothing in this Agreement shall
           create or imply any license or grant of rights to either party under,
           or act as a waiver as of, any rights that the other party may have to
           prevent infringement or misappropriation of any patents, patent
           applications, trademarks, copyrights, trade secrets, know how or
           other intellectual property rights owned or controlled by such other
           party or any of its Affiliates.

     10.14 Except with the express written consent of a party in each instance,
           neither party nor its Affiliates, officers or employees will at
           anytime include such party's name (or that of any of its Affiliates,
           shareholders, officers, directors, employees or personnel) in any
           written material, marketing or advertising brochures, bids,
           contracts, proposals, applications or otherwise, except as may be
           required by law, or in any way represent or imply that such party or
           its Affiliates, shareholders, officers, directors, employees or
           personnel have endorsed the other party or its business.

     10.15 This Agreement may be executed in two or more counterparts, all of
           which constitute one and the same legal instrument.

     10.16 CUSTOMER and Orchid agree to execute, acknowledge, and deliver such
           further instruments and to do all such other acts as may be necessary
           or appropriate to effect the purpose and intent of this Agreement.

     10.17 Each party hereby represents and warrants to the other that: (i)
           such party is duly organized and validly existing under the laws of
           the state of its incorporation and has full corporate power and
           authority to enter into this Agreement and to carry out the
           provisions hereof; (ii) such party has the requisite power and
           authority and the legal right, and has taken all necessary actions on
           its part, to enter into this Agreement and to perform its obligations
           and grant the rights extended by it hereunder; (iii) this Agreement
           has been duly executed and delivered on such party's behalf, is a
           legal and valid obligation binding upon it and is enforceable in
           accordance with its terms; (iv) the execution, delivery and
           performance of this Agreement by such party do not conflict with any
           agreement, instrument or understanding, oral or written, to which it
           is a party or by which it may be bound, nor violate any law or
           regulation of any court, governmental body or administrative or other
           agency having authority over it; and (v) all necessary consents,
           approvals and authorizations of all governmental authorities and
           other persons required to be obtained by such party in connection
           with the execution and performance of this Agreement have been
           obtained.

                                       19
<PAGE>

IN WITNESS WHEREOF, the parties have executed this Agreement as of the Effective
Date.

BRISTOL-MYERS SQUIBB COMPANY    ORCHID BIOSCIENCES, INC.

By: /s/ Marilyn Hartig          By: /s/ Donald R. Marvin
    ------------------              --------------------

Title: VP, External             Title: SVP, COO and CFO
Science & Tech.                        ----------------
-------------------

                                      20
<PAGE>

                            Schedules To Be Attached
                            ------------------------

1.5   Consumables List

1.15  Specifications for SNPstream Instrument, Software Package and Consumables

2.1.1 Terms for providing SNPstream Instrument including delivery and
      installation date, price schedule, termination date, short fall fee and
      termination fee

2.1.2 Standard Terms and Conditions of Delivery and Installation

2.2.1 Standard Terms and Conditions of Training

2.2.2 Standard Terms and Conditions of Support

2.5   Standard Terms and Conditions of Removal

                                       21
<PAGE>

                         SNPSTREAM CONTRACT SCHEDULES:

1.5   [*]

1.15  Specifications for SNPstream Instrument, Software Package and Consumables:

[*]

[*]

[*]

SNPstream Consumables Specifications:
-------------------------------------

Reagent Kit Specifications: See schedule 1.5.

[*]

[*]

[*]

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

<PAGE>

2.1.1  Terms for providing SNPstream Instrument including delivery and
installation timelines, purchase option, price schedule, termination date, short
fall fee and terminations fee.

A SNPstream System will be provided to customer for the purpose of automated SNP
analysis under the following terms:

Delivery and Installation:
--------------------------

[*]

[*]

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

<PAGE>

2.1.2  Standard Terms and Conditions of Delivery and Installation:

Orchid or its Authorized Representative will install the SNPstream instrument at
a site designated by the client.   The client must have the designated location
for installation prequalified by Orchid or an Authorized Representative to meet
certain criteria defined as such:

 .  Space Requirements

     The 3m ORCA will require a working surface space of 180" (457cm) x 90"
          (229cm).  It is also recommended to include a 36" (91cm) access space
          around the entire system.  The entire floor spacing surrounding the
          system should be completely unobstructed from any plumbing,
          electrical, conduits, chases, other mechanical features, etc.

 .  Air Requirements

     The Multimek system requires clean, filtered air regulated to 85 psi to the
          system for use.  The air supply should terminate at the system with a
          1/4" NPT FEMALE fitting. If house air is not available, a compressor
          will be provided with the SNPstream Instrument.

 .  Electrical Requirements

     The minimum requirement for this system is four 15Amp circuits, or three
     20Amp circuits for power.  The optimal case is four 20 amp circuits.  For
     each of the 6 optical tables required there should be a 6-outlet power
     strip.  Each of these outlet strips is then connected to the provided
     circuits.

<TABLE>
<CAPTION>
----------------------------------------------------------------------------------------------------------------------
DEVICE                                    ELEC. CUR. @ 120V            AIR        VAC               COMMENTS
                                                (amps)
----------------------------------------------------------------------------------------------------------------------
<S>                                 <C>                             <C>        <C>        <C>
Host Computers                                    3
----------------------------------------------------------------------------------------------------------------------
Host Monitors                                    1.5
----------------------------------------------------------------------------------------------------------------------
ORCA Robot                                        6
----------------------------------------------------------------------------------------------------------------------
96-Channel Pipettor                              3.5                    Y
----------------------------------------------------------------------------------------------------------------------
Deck Controller                                  1.5                    Y          Y
----------------------------------------------------------------------------------------------------------------------
Ambient Carousel                                 1.5
----------------------------------------------------------------------------------------------------------------------
Master Flex Console Drive                        3.0
----------------------------------------------------------------------------------------------------------------------
LabLine Shaker                                    1
----------------------------------------------------------------------------------------------------------------------
EL405 Microplate Washer                          6.3                    Y*         Y*         * Unless provided by P/V
                                                                                                pump.
----------------------------------------------------------------------------------------------------------------------
EL405 Microplate Washer                           5
 Pressure/Vacuum
----------------------------------------------------------------------------------------------------------------------
Bar Code Reader                                  0.5
----------------------------------------------------------------------------------------------------------------------
BMG FLUOstar 97                                   2
----------------------------------------------------------------------------------------------------------------------
Best UPS                                          12                                          Provides 1.4 kVA of
                                                                                              battery backup
----------------------------------------------------------------------------------------------------------------------
Multidrop 384                                     .6
----------------------------------------------------------------------------------------------------------------------
</TABLE>

<PAGE>

 .    Plumbing Requirements

     This system includes a tip-wash station, refillable reservoirs, waste
          reservoirs, and plate washers.  Use of any of these components will
          require tubing routing and some regard to placement of the system, as
          these require regular maintenance in the form of filling and/or
          emptying.

     Orchid or an Authorized Representative will perform installation of the
     SNPstream Instrument after delivery.  Installation will require
     approximately 10 days to complete. Commissioning, verification of the
     SNPstream functionality for GBA-based SNP genotyping, will occur within the
     installation time frame and the installation shall not be considered
     complete until such functionality is verified to CUSTOMER's reasonable
     satisfaction.

<PAGE>

2.2.1  Standard Terms and Conditions of Training:

[*]

[*]

[*]

[*] CONFIDENTIAL MATERIAL OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION. ASTERISKS DENOTE SUCH OMISSIONS.

<PAGE>

ORCA and Multimek are trademarks of Beckman Coulter Inc.
EL405 Microplate Washer is a trademark of Bio-Tek Instruments
FLUOstar 97 is a trademark of BMG Lab Technologies, Inc.
Windows is a registered trademark of Microsoft Corp

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