Document:

<PAGE>

                                                                   Exhibit 10.62
                                                                Execution Copy I

                       INCARA PHARMACEUTICALS CORPORATION
                          REGISTRATION RIGHTS AGREEMENT
                          -----------------------------

          THIS REGISTRATION RIGHTS AGREEMENT (the "Agreement") is made as of
                                                   ---------
December 21, 2000, by and among Incara Pharmaceuticals Corporation, a Delaware
corporation (the "Company"), Elan International Services, Ltd., a Bermuda
                  -------
exempted limited liability company ("EIS"), and Elan Pharma International
                                     ---
Limited, an Irish private limited liability company ("EPIL").
                                                      ----

                                R E C I T A L S:

          A.   Pursuant to a Securities Purchase Agreement dated as of the date
hereof by and among the Company, EIS and EPIL (the "Purchase Agreement"), (i)
                                                    ------------------
EIS has acquired, or will acquire in the future, (a) certain shares of common
stock, par value $0.001 per share of the Company (the "Common Stock"), (b)
                                                       ------------
Series C Convertible Exchangeable Preferred Stock of the Company (the "Series C
                                                                       --------
Preferred Stock") convertible into shares of Series B Preferred Stock of the
---------------
Company, which, in turn, is convertible into shares of Common Stock, (c) certain
shares of Series B Convertible Preferred Stock of the Company (the "Series B
                                                                    --------
Preferred Stock") and (d) a warrant (the "Warrant") to purchase certain shares
---------------                           -------
of Series B Preferred Stock, and (ii) EPIL has acquired a certain note of the
Company (the "Note") convertible into shares of Series B Preferred Stock.  The
              ----
Common Stock, the Series B Preferred Stock, the Series C Preferred Stock, the
Warrant and the Note collectively are referred to herein as the "Securities."
                                                                 ----------

          B.   The execution of the Purchase Agreement has occurred as of the
date hereof and it is a condition to the closing of the transactions
contemplated thereby that the parties execute and deliver this Agreement.

          C.   The parties desire to set forth herein their agreement on the
terms and subject to the conditions set forth herein related to the granting of
certain registration rights to the Holders (as defined below) relating to the
Common Stock issuable upon conversion or exercise of the Securities by such
Holders.

                               A G R E E M E N T:

          The parties hereto agree as follows:

     1.   Certain Definitions. As used in this Agreement, the following terms
          -------------------
shall have the following respective meanings:

          "Commission" shall mean the U.S. Securities and Exchange Commission.
           ----------
<PAGE>

          "Exchange Act" shall mean the U.S. Securities Exchange Act of 1934, as
           ------------
amended, and the rules and regulations of the Commission thereunder, all as the
same shall be in effect from time to time.

          "Holders" or "Holders of Registrable Securities" shall mean EIS, EPIL
           -------      ---------------------------------
and any Person who shall have acquired Registrable Securities from EIS or EPIL
as permitted herein and in the Purchase Agreement, either individually or
jointly, as the case may be, in a transaction pursuant to which registration
rights are transferred pursuant to Section 10 hereof.

          "Person" shall mean an individual, a partnership, a limited liability
           ------
company, company, a corporation, an association, a joint stock company, a trust,
a joint venture, an unincorporated organization or a governmental or quasi-
governmental entity, or any department, agency or political subdivision thereof.

          "Registrable Securities" means (i) any shares of Common Stock
           ----------------------
subscribed for, (ii) any shares of Common Stock issued or issuable upon
conversion or exercise of any of the other Securities; and (iii) any shares of
Common Stock issued or issuable in respect of the securities referred to in
clauses (i) and (ii) above, until, in the case of any such security, it is
effectively registered under the Securities Act and disposed of in accordance
with the registration statement covering it; excluding in all cases, however,
any Registrable Securities that may be sold under Rule 144(k) promulgated under
the Securities Act, as such rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission, and Registrable
Securities sold by a Person in a transaction (including a transaction pursuant
to a registration statement under this Agreement and a transaction pursuant to
Rule 144 promulgated under the Securities Act) in which registration rights are
not transferred pursuant to Section 10 hereof. Whenever a number or percentage
of Registrable Securities is to be determined pursuant to this Agreement, each
then outstanding Security that is convertible into or exercisable for shares of
Common Stock will be deemed to be equal to the number of shares of Common Stock
for which such Security is then so convertible or exercisable.

          The terms "register," "registered" and "registration" refer to a
                     --------    ----------       ------------
registration effected by preparing and filing a registration statement in
compliance with the Securities Act.

          "Registration Expenses" shall mean all expenses, other than Selling
           ---------------------
Expenses, incurred by the Company in complying with Sections 2 or 3 hereof,
including without limitation, all registration, qualification and filing fees,
exchange listing fees, printing expenses, escrow fees, fees and disbursements of
counsel for the Company, blue sky fees and expenses, the expense of any special
audits incident to or required by any such registration.

          "Securities Act" shall mean the Securities Act of 1933, as amended.
           --------------

          "Selling Expenses" shall mean all underwriting discounts, selling
           ----------------
commissions and stock transfer taxes and the costs, fees and expenses of any
accountants, attorneys or other experts retained by the Holders.

                                       2
<PAGE>

     2.   Demand Registrations.
          --------------------

          (a)  Requests for Registration. From and after the date hereof, any
               -------------------------
Holder or Holders who collectively hold Registrable Securities representing at
least 5% of the Registrable Securities then outstanding shall have the right
(subject to the limitations below) to request registration under the Securities
Act of all or part of their Registrable Securities on Form S-1 or S-3 (or any
successor form to Form S-1 or S-3, or any similar short-form registration
statement) (each, a "Demand Registration"). The request for the Demand
                     -------------------
Registration shall specify the approximate number of Registrable Securities
requested to be registered, which must have a minimum expected aggregate
offering price to the public of at least U.S.$1,000,000. Within 10 days after
receipt of any such request, the Company will give written notice of such
requested registration to all other Holders of Registrable Securities. The
Company shall include such other Holders' Registrable Securities in such
offering if they have responded affirmatively within 10 days after the receipt
of the Company's notice. The Holders shall in the aggregate be permitted a total
of one Demand Registration hereunder. A registration will not count as a
permitted Demand Registration until it has become effective (unless such Demand
Registration has not become effective due solely to the fault of the Holders
requesting such registration, including a request by such Holders that such
registration be withdrawn).

          (b)  Priority on Demand Registrations. If a Demand Registration is an
               --------------------------------
underwritten offering and the managing underwriters advise the Company in
writing that in their opinion the number of Registrable Securities and, if
permitted hereunder, other securities requested to be included in such offering,
exceeds the number of Registrable Securities and other securities, if any, which
can be sold in such offering without adversely affecting the marketability of
the offering, the Company will include in such registration:

          (i)  first, the Registrable Securities requested to be included in
     such registration by the Holders (if necessary, such Registrable Securities
     pro rata among the Holders thereof based upon the number of Registrable
     --- ----
     Securities owned by each such Holder); and

          (ii) thereafter, other securities requested to be included in such
     registration, as determined by the Company.

          (c)  Restrictions on Demand Registration. The Company may postpone or
               -----------------------------------
suspend for up to three months in any 12-month period the filing or the
effectiveness of a registration statement for a Demand Registration if the
Company determines in good faith that such Demand Registration (i) would
reasonably be expected to have a material adverse effect on (x) any proposal or
plan by the Company to engage in any financing, acquisition or disposition of
assets (other than in the ordinary course of business) or (y) any merger,
consolidation, tender offer or similar transaction or (ii) would require
disclosure of any information that the board of directors of the Company
reasonably and determines in good faith would be detrimental to the Company;
provided, however, that in such event, the Holders initially requesting such
--------  -------
Demand Registration will be entitled to withdraw such request and, if such
request is withdrawn, such Demand Registration will not count as a permitted
Demand Registration hereunder and the Company will pay any Registration Expenses
in connection with such registration.

                                       3
<PAGE>

          (d)   Selection of Underwriters. The Holders will have the right to
                -------------------------
select the investment banker(s) and manager(s) to administer an offering
pursuant to the Demand Registration, subject to the Company's prior written
approval, which will not be unreasonably withheld, delayed or conditioned.

          (e)   Other Registration Rights. Except as provided in this Agreement,
                -------------------------
so long as any Holder owns any Registrable Securities, the Company will not
grant to any Persons the right to require the Company to register any equity
securities of the Company, or any securities convertible or exchangeable into or
exercisable for such securities, which conflicts with the rights granted to the
Holders hereunder, without the prior written consent of the Holders of at least
50% of the Registrable Securities.

     3.   Piggyback Registrations.
          -----------------------

          (a)   Right to Piggyback. Except with respect to any registration
                ------------------
statements filed on or before January 19, 2001, if at any time the Company shall
propose to register shares of Common Stock under the Securities Act (other than
an existing or proposed registration statement as disclosed in the Purchase
Agreement, or in a registration statement on Form S-3 relating to sales of
securities to participants in a Company dividend reinvestment plan, or Form S-4
or S-8 or any successor form or in connection with an acquisition or exchange
offer or an offering of securities solely to the existing shareholders or
employees of the Company) (each, a "Piggyback Registration"), the Company (i)
                                    ----------------------
will give prompt written notice to all Holders of Registrable Securities of its
intention to effect such a registration and (ii) subject to Section 3(b) and the
other terms of this Agreement, will include in such registration all Registrable
Securities which are permitted under applicable securities laws to be included
in the form of registration statement selected by the Company and with respect
to which the Company has received written requests for inclusion therein within
30 days after the receipt of the Company's notice.  The Holders will be
permitted to withdraw all or any part of the Registrable Securities from a
Piggyback Registration at any time prior to the effective date of such Piggyback
Registration.

          (b)   Priority on Piggyback Registrations. If a Piggyback Registration
                -----------------------------------
is to be an underwritten offering, and the managing underwriters advise the
Company in writing that in their opinion the number of securities requested to
be included in such registration exceeds the number which can be sold in such
offering without adversely affecting the marketability of the offering, the
Company will include in such registration:

          (i)   first, the securities the Company proposes to sell;

          (ii)  second, the Registrable Securities requested to be included in
     such registration by the Holders and any securities requested to be
     included in such registration by any other Person, other than Persons
     having a lower priority of registration than the Holders, pro rata among
                                                               --- ----
     the Holders of such Registrable Securities and such other Persons, on the
     basis of the number of securities requested to be included in such
     registration by each of such Holders and such other Persons; and

          (iii) thereafter, other securities requested to be included in such
     registration, as determined by the Company.

                                       4
<PAGE>

          The Holders of any Registrable Securities included in such an
underwritten offering will execute an underwriting agreement in customary form
and in form and substance satisfactory to the managing underwriters.

          (c)  Right to Terminate Registration. If at any time after giving
               -------------------------------
written notice of its intention to register any of its securities as set forth
in Section 3(a) and prior to the effective date of the registration statement
filed in connection with such registration, the Company shall determine for any
reason not to register such securities, the Company may, at its election, give
written notice of such determination to each Holder of Registrable Securities
and thereupon be relieved of its obligation to register any Registrable
Securities in connection with such registration (but not from its obligation to
pay the Registration Expenses in connection therewith as provided herein).

          (d)  Selection of Underwriters. The Company will have the right to
               -------------------------
select the investment banker(s) and manager(s) to administer an offering
pursuant to a Piggyback Registration, subject to the approval of the holders of
a majority of the Registrable Securities, which approval will not be
unreasonably withheld, delayed or conditioned.

     4.   Expenses of Registration.
          ------------------------

          Except as otherwise provided herein or as may otherwise be prohibited
by applicable law, all Registration Expenses incurred in connection with all
registrations pursuant to Sections 2 and 3 hereof shall be borne by the Company.
All Selling Expenses relating to securities registered on behalf of the Holders
of Registrable Securities shall be borne by such Holders pro rata according to
their relative ownership percentages of such securities.

     5.   Holdback Agreements.
          -------------------

          (a)  The Company agrees (i) not to effect any public sale or
distribution of its equity securities, or any securities convertible into or
exchangeable or exercisable for such securities, during the 10-day period prior
to, and during the 90-day period following, the effective date of any
underwritten Demand Registration or any underwritten Piggyback Registration
(except as part of such underwritten registration or pursuant to registration
statements on Form S-4 or Form S-8 or any successor form), unless the
underwriters managing the registered public offering otherwise agree, and (ii)
to use all reasonable efforts to cause its officers and directors and each
holder of at least 5% (on a fully-diluted basis) of its outstanding shares of
Common Stock, or any securities convertible into or exchangeable or exercisable
for shares of Common Stock, purchased from the Company at any time after the
date of this Agreement (other than in a registered public offering) to agree not
to effect any public sale or distribution (including sales pursuant to Rule 144)
of any such securities during such periods (except as part of such underwritten
registration, if otherwise permitted), unless the underwriters managing the
registered public offering otherwise agree.

          (b)  Each Holder agrees, if requested by the managing underwriters in
an underwritten offering of Common Stock or securities convertible for Common
Stock of the Company (including without limitation the Company's initial public
offering of Common Stock), not to effect any offer, sale, distribution or
transfer, including a sale pursuant to Rule 144

                                       5
<PAGE>

(or any similar provision then effect) under the Securities Act (except as part
of such underwritten registration), during the 10-day period prior to, and
during the 180-day period in the case of the Company's initial public offering
or a 90-day period in the case of any other offering of Common Stock (or, in
each case, such shorter period as may be agreed to in writing by the Company and
the Holders of at least 50% of the Registrable Securities) following, the
effective date of such Registration Statement; provided, however, that no Holder
                                               --------  -------
shall be required to enter into more than one such agreement in any 12-month
period.

     6.   Registration Procedures.
          -----------------------

          Whenever the Holders of Registrable Securities have requested that any
Registrable Securities be registered pursuant to this Agreement, the Company
will use reasonable best  efforts to effect the registration and the sale of
such Registrable Securities in accordance with the intended method or methods of
distribution thereof, and pursuant thereto the Company will as expeditiously as
possible:
          (a)  subject to Section 2(c) hereof, prepare and file with the
     Commission a registration statement on any appropriate form for which the
     Company qualifies with respect to such Registrable Securities and use all
     reasonable efforts to cause such registration statement to become effective
     (provided that before filing a registration statement or prospectus or any
      --------
     amendments or supplements thereto, the Company will (i) furnish to the
     counsel selected by the selling Holders copies of all such documents
     proposed to be filed, which documents will be subject to the review of such
     counsel, and (ii) notify each Holder of Registrable Securities covered by
     such registration of any stop order issued or threatened by the
     Commission);

          (b)  subject to Section 2(c) hereof, prepare and file with the
     Commission such amendments and supplements to such registration statement
     and the prospectus used in connection therewith as may be reasonably
     necessary to keep such registration statement effective for a period equal
     to the shorter of (i) six months and (ii) the time by which all securities
     covered by such registration statement have been sold, and comply with the
     provisions of the Securities Act with respect to the disposition of all
     securities covered by such registration statement during such period in
     accordance with the intended methods of disposition by the sellers thereof
     set forth in such registration statement;

          (c)  furnish to each seller of Registrable Securities such number of
     copies of such registration statement, each amendment and supplement
     thereto, the prospectus included in such registration statement (including
     each preliminary prospectus) and such other documents as such seller may
     reasonably request in order to facilitate the disposition of the
     Registrable Securities owned by such seller;

          (d)  use all reasonable efforts to register or qualify such
     Registrable Securities under the securities or blue sky laws of such
     jurisdictions as any seller reasonably requests and do any and all other
     acts and things which may be reasonably necessary or advisable to enable
     such seller to consummate the disposition in such jurisdictions of the
     Registrable Securities owned by such seller (provided that the Company will
                                                  --------
     not be required to (i) qualify generally to do business in any jurisdiction
     where it would not

                                       6
<PAGE>

     otherwise be required to qualify but for this Section 6(d), (ii) subject
     itself to taxation in any jurisdiction or (iii) take any action that would
     subject it to general service of process in any such jurisdiction);

          (e)  notify each seller of such Registrable Securities, at any time
     when a prospectus relating thereto is required to be delivered under the
     Securities Act, of the happening of any event as a result of which the
     prospectus included in such registration statement contains an untrue
     statement of a material fact or omits any fact necessary to make the
     statements therein not misleading, and, at the request of any such seller,
     the Company will prepare a supplement or amendment to such prospectus so
     that, as thereafter delivered to the purchasers of such Registrable
     Securities, such prospectus will not contain an untrue statement of a
     material fact or omit to state any fact necessary to make the statements
     therein not misleading; provided, however, that the Company shall not be
                             --------  -------
     required to amend the registration statement or supplement the Prospectus
     for a period of up to six months if the board of directors determines in
     good faith that to do so would reasonably be expected to have a material
     adverse effect on any proposal or plan by the Company to engage in any
     financing, acquisition or disposition of assets (other than in the ordinary
     course of business) or any merger, consolidation, tender offer or similar
     transaction or would require the disclosure of any information that the
     board of directors determines in good faith the disclosure of which would
     be detrimental to the Company, it being understood that the period for
     which the Company is obligated to keep the Registration Statement effective
     shall be extended for a number of days equal to the number of days the
     Company delays amendments or supplements pursuant to this provision.  Upon
     receipt of any notice pursuant to this Section 6(e), the Holders shall
     suspend all offers and sales of securities of the Company and all use of
     any prospectus until advised by the Company that offers and sales may
     resume, and shall keep confidential the fact and content of any notice
     given by the Company pursuant to this Section 6(e);

          (f)  cause all such Registrable Securities to be listed on each
     securities exchange, if any, on which similar securities issued by the
     Company are then listed;

          (g)  provide a transfer agent and registrar for all such Registrable
     Securities not later than the effective date of such registration
     statement;

          (h)  enter into such customary agreements (including underwriting
     agreements in customary form) and take all such other actions as the
     Holders of a majority of the Registrable Securities being sold or the
     underwriters, if any, reasonably request in order to expedite or facilitate
     the disposition of such Registrable Securities;

          (i)  make available for inspection by a representative of the Holders
     of Registrable Securities included in the registration statement, any
     underwriter participating in any disposition pursuant to such registration
     statement and any attorney, accountant or other agent retained by any such
     Holder or underwriter, all pertinent financial and other records, pertinent
     corporate documents and properties of the Company, and cause the Company's
     officers, directors, employees and independent accountants to supply all

                                       7
<PAGE>

     information reasonably requested by any such Holder, underwriter, attorney,
     accountant or agent in connection with such registration statement;

          (j)  otherwise use its reasonable efforts to comply with all
     applicable rules and regulations of the Commission, and make available to
     its security holders, as soon as reasonably practicable, an earnings
     statement covering the period of at least 12 months beginning with the
     first day of the Company's first full calendar quarter after the effective
     date of the registration statement, which earnings statement shall satisfy
     the provisions of Section 11(a) of the Securities Act and Rule 158
     thereunder;

          (k)  in the event of the issuance of any stop order suspending the
     effectiveness of a registration statement, or of any order suspending or
     preventing the use of any related prospectus or suspending the
     qualification of any shares of Common Stock included in such registration
     statement for sale in any jurisdiction, use all reasonable efforts promptly
     to obtain the withdrawal of such order; and

          (l)  if the registration is an underwritten offering, use all
     reasonable efforts to obtain a so-called "cold comfort" letter from the
     Company's independent public accountants in customary form and covering
     such matters of the type customarily covered by cold comfort letters.

     7.   Obligations of Holders.
          ----------------------

          Whenever the Holders of Registrable Securities sell any Registrable
Securities pursuant to a Demand Registration or a Piggyback Registration, such
Holders shall be obligated to comply with the applicable provisions of the
Securities Act, including the prospectus delivery requirements thereunder, and
any applicable state securities or blue sky laws.  In addition, each Holder of
Registrable Securities will be deemed to have agreed by virtue of its
acquisition of such Registrable Securities that, upon receipt of any notice
described in Section 6(e), such Holder will forthwith discontinue disposition of
such Registrable Securities covered by such registration statement or prospectus
until such Holder's receipt of the copies of the supplemented or amended
prospectus contemplated by Section 6(e), or until it is advised in writing by
the Company that the use of the applicable prospectus may be resumed, and has
received copies of any additional or supplemental filings that are incorporated
or deemed to be incorporated by reference in such prospectus.

     8.   Indemnification.
          ---------------

          (a)  The Company agrees to indemnify, to the fullest extent permitted
by applicable law, each Holder of Registrable Securities, its officers and
directors and each Person who controls such Holder (within the meaning of the
Securities Act) against all losses, claims, damages, liabilities, expenses or
any amounts paid in settlement of any litigation, investigation or proceeding
commenced or threatened (collectively, "Claims") to which each such indemnified
                                        ------
party may become subject under the Securities Act insofar as such Claim arose
out of (i) any untrue or alleged untrue statement of material fact contained, on
the effective date thereof, in any registration statement, prospectus or
preliminary prospectus or any amendment thereof or supplement thereto or (ii)
any omission or alleged omission to state therein a material fact

                                       8
<PAGE>

required to be stated therein or necessary to make the statements therein not
misleading, except insofar as the same are caused by or contained in any
information furnished in writing to the Company by such Holder expressly for use
therein, by such Holder's failure to deliver a copy of the registration
statement or prospectus or any amendments or supplements thereto after the
Company has furnished such Holder with a sufficient number of copies of the same
or by such Holder's failure to comply with applicable securities laws. In
connection with an underwritten offering, the Company will indemnify the
underwriters, their officers and directors and each Person who controls the
underwriters (within the meaning of the Securities Act) to the same extent as
provided above with respect to the indemnification of the Holders of Registrable
Securities.

          (b)  In connection with any registration statements in which a Holder
of Registrable Securities is participating, each such Holder will, to the
fullest extent permitted by applicable law, indemnify the Company, its directors
and officers and each Person who controls the Company (within the meaning of the
Securities Act) against any and all Claims to which each such indemnified party
may become subject under the Securities Act insofar as such Claim arose out of
(i) any untrue or alleged untrue statement of material fact contained, on the
effective date thereof, in any registration statement, prospectus or preliminary
prospectus or any amendment thereof or supplement thereto, (ii) any omission or
alleged omission to state therein a material fact required to be stated therein
or necessary to make the statements therein not misleading or (iii) any failure
to comply with applicable securities laws; provided that with respect to a Claim
                                           --------
arising pursuant to clause (i) or (ii) above, the material misstatement or
omission is contained in the written information such Holder provided to the
Company pursuant to Section 11 hereof; provided, further, that the obligation to
                                       --------  -------
indemnify will be individual to each Holder and will be limited to the amount of
proceeds received by such Holder from the sale of Registrable Securities
pursuant to such registration statement.

          (c)  Any Person entitled to indemnification hereunder will (i) give
prompt written notice to the indemnifying party of any claim with respect to
which it seeks indemnification (but the failure to provide such notice shall not
release the indemnifying party of its obligation under paragraphs (a) and (b),
unless and then only to the extent that, the indemnifying party has been
prejudiced by such failure to provide such notice) and (ii) unless in such
indemnified party's reasonable judgment, based on written advice of counsel, a
conflict of interest between such indemnified and indemnifying parties may exist
with respect to such claim, permit such indemnifying party to assume the defense
of such claim with counsel reasonably satisfactory to the indemnified party. An
indemnifying party who is not entitled to, or elects not to, assume the defense
of a claim will not be obligated to pay the fees and expenses of more than one
counsel for all parties indemnified by such indemnifying party with respect to
such claim, unless in the reasonable judgment of any indemnified party, based on
written advice of counsel, a conflict of interest may exist between such
indemnified party and any other of such indemnified parties with respect to such
claim.

          (d)  The indemnifying party shall not be liable to indemnify an
indemnified party for any settlement, or consent to judgment of any such action
effected without the indemnifying party's written consent (but such consent will
not be unreasonably withheld, delayed or conditioned). Furthermore, the
indemnifying party shall not, except with the prior written approval of each
indemnified party, consent to entry of any judgment or enter into any

                                       9
<PAGE>

settlement which does not include as an unconditional term thereof the giving by
the claimant or plaintiff to each indemnified party of a release from all
liability in respect of such claim or litigation without any payment or
consideration provided by each such indemnified party.

          (e)  If the indemnification provided for in this Section 8 is
unavailable to an indemnified party under clauses (a) and (b) above in respect
of any Claims, then each indemnifying party, in lieu of indemnifying such
indemnified party, shall contribute to the amount paid or payable by such
indemnified party as a result of such Claims in such proportion as is
appropriate to reflect not only the relative benefits received by the Company,
the underwriters, the sellers of Registrable Securities and any other sellers
participating in the registration statement from the sale of shares pursuant to
the registered offering of securities for which indemnity is sought but also the
relative fault of the Company, the underwriters, the sellers of Registrable
Securities and any other sellers participating in the registration statement in
connection with the misstatement or omission which resulted in such Claims, as
well as any other relevant equitable considerations. The relative benefits
received by the Company, the underwriters, the sellers of Registrable Securities
and any other sellers participating in the registration statement shall be
deemed to be based on the relative relationship of the total net proceeds from
the offering (before deducting expenses) to the Company, the total underwriting
commissions and fees from the offering (before deducting expenses) to the
underwriters and the total net proceeds from the offering (before deducting
expenses) to the sellers of Registrable Securities and any other sellers
participating in the registration statement. The relative fault of the Company,
the underwriters, the sellers of Registrable Securities and any other sellers
participating in the registration statement shall be determined by reference to,
among other things, whether the untrue or alleged untrue statement of a material
fact or the omission or alleged omission to state a material fact relates to
information supplied by the Company or by the sellers of Registrable Securities
and the parties' relative intent, knowledge, access to information and
opportunity to correct or prevent such statement or omission; provided that in
                                                              --------
no event shall the liability of any selling Holder hereunder be greater in
amount than the dollar amount of the proceeds received by such Holder upon the
sale of the Registrable Securities giving rise to such indemnification
obligation.

          (f)  The indemnification provided for under this Agreement will remain
in full force and effect regardless of any investigation made by or on behalf of
the indemnified party or any officer, director or controlling person of such
indemnified party and will survive the transfer of the Registrable Securities.

     9.   Participation in Underwritten Registrations.
          -------------------------------------------

          No Holder may participate in any registration hereunder which is
underwritten unless such Holder (a) agrees to sell such Holder's securities on
the basis provided in any underwriting arrangements approved by the Holder or
Holders entitled hereunder to approve such arrangements, (b) as expeditiously as
possible notifies the Company of the occurrence of any event as a result of
which any prospectus contains an untrue statement of material fact or omits to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading and (c) completes and executes all
questionnaires, powers of attorney, indemnities, underwriting agreements and
other documents reasonably required under the terms of such underwriting
arrangements.

                                       10
<PAGE>

     10.  Transfer of Registration Rights.
          -------------------------------

          The rights granted to any Holder under this Agreement may be assigned
to any permitted transferee of Registrable Securities, in connection with any
transfer or assignment of Registrable Securities by a Holder; provided, however,
                                                              --------  -------
that: (a) such transfer is otherwise effected in accordance with applicable
securities laws, (b) such transfer is permitted by the Purchase Agreement, (c)
if not already a party hereto, the assignee or transferee agrees in writing
prior to such transfer to be bound by the provisions of this Agreement
applicable to the transferor and (d) EIS shall act as agent and representative
for such Holder for the giving and receiving of notices hereunder.

     11.  Information by Holder.
          ---------------------

          Each Holder shall furnish to the Company such written information
regarding such Holder and any distribution proposed by such Holder as the
Company may reasonably request in writing and as shall be reasonably required in
connection with any registration, qualification or compliance referred to in
this Agreement and shall promptly notify the Company of any changes in such
information.

     12.  Exchange Act Compliance.
          -----------------------

          The Company shall comply with all of the reporting requirements of the
Exchange Act then applicable to it, if any, and shall comply with all other
public information reporting requirements of the Commission which are conditions
to the availability of Rule 144 for the sale of the Registrable Securities. The
Company shall cooperate with each Holder in supplying such information as may be
necessary for such Holder to complete and file any information reporting forms
presently or hereafter required by the Commission as a condition to the
availability of Rule 144.

     13.  Termination of Registration Rights.
          ----------------------------------

          All registration rights and obligations (including, without
limitation, under Section 5) under this Agreement shall terminate and be of no
further force and effect, as to any particular Holder, at such time as all
Registrable Securities held by such Holder are eligible to be sold without
compliance with the registration requirements of the Securities Act pursuant to
Rule 144(k) promulgated thereunder or have been resold pursuant to a
registration statement hereunder.

     14.  Miscellaneous.
          -------------

          (a)  No Inconsistent Agreements. The Company will not hereafter enter
               --------------------------
into any agreement with respect to its securities which is inconsistent with or
violates the rights granted to the Holders of Registrable Securities in this
Agreement without the prior written consent of a majority in interest of such
Registrable Securities.

          (b)  Remedies. Any Person having rights under any provision of this
               --------
Agreement will be entitled to enforce such rights specifically to recover
damages caused by reason of any breach of any provision of this Agreement and to
exercise all other rights granted

                                       11
<PAGE>

by law. The parties hereto agree and acknowledge that money damages may not be
an adequate remedy for any breach of the provisions of this Agreement and that
any party may in its sole discretion apply to any court of law or equity of
competent jurisdiction (without posting any bond or other security) for specific
performance and for other injunctive relief in order to enforce or prevent
violation of the provisions of this Agreement; provided, however, that in no
                                               --------  -------
event shall any Holder have the right to enjoin, delay or interfere with any
offering of securities by the Company.

          (c)  Amendments and Waivers. Except as otherwise provided herein, the
               ----------------------
provisions of this Agreement may be amended or waived only with the prior
written consent of the Company and Holders of at least 50% of the Registrable
Securities; provided, however, that without the prior written consent of all the
            --------  -------
Holders, no such amendment or waiver shall reduce the foregoing percentage
required to amend or waive any provision of this Agreement.

          (d)  Successors and Assigns. This Agreement and all of the provisions
               ----------------------
hereof shall be binding upon and inure to the benefit of the parties and their
respective successors and permitted assigns. This Agreement may be transferred
by EIS, EPIL and their permitted assigns and transferees to their respective
affiliates and subsidiaries, as well as any special purpose financing or similar
vehicle established by EIS or EPIL. Other than as set forth above, no party
shall transfer or assign this Agreement without the prior written consent of the
other party, which will not be unreasonably withheld, delayed or conditioned. In
addition, whether or not any express assignment has been made, the provisions of
this Agreement which are for the benefit of Holders of Registrable Securities
are also for the benefit of, and enforceable by, any permitted transferee of
Registrable Securities, in accordance with Section 10 hereof.

          (e)  Severability. In case any provision of this Agreement shall be
               ------------
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions shall not be in any way affected or impaired thereby.

          (f)  Counterparts and Facsimile. This Agreement may be executed in any
               --------------------------
number of counterparts, and each such counterpart hereof shall be deemed to be
an original instrument, but all such counterparts together shall constitute one
agreement.  This Agreement may be signed and delivered to the other party by
facsimile transmission; such transmission shall be deemed a valid signature.

          (g)  Descriptive Headings. The section and paragraph headings
               --------------------
contained in this Agreement are for reference purposes only and shall not affect
in any way the meaning or interpretation of this Agreement.

          (h)  Governing Law; Disputes. This Agreement shall be governed by and
               -----------------------
construed in accordance with the internal laws of the State of New York, without
giving effect to principles of conflicts of laws. Any dispute under this
Agreement that is not settled by mutual consent may be finally adjudicated by
any federal or state court sitting in the City, County and State of New York,
and each party consents to the non-exclusive jurisdiction of such courts (or any
appellate court therefrom) over any such dispute. Nothing contained in this
Section shall prevent the adjudication of any dispute under this Agreement by
any other state or federal court, regardless of location, so long as such court
has jurisdiction and is located in a proper venue.

                                       12
<PAGE>

          (i)     Notices. All notices, demands and requests of any kind to be
                  -------
delivered to any party in connection with this Agreement shall be in writing and
shall be deemed to have been duly given if personally or hand delivered or if
sent by internationally-recognized overnight courier or by registered or
certified mail, return receipt requested and postage prepaid, or by facsimile
transmission, addressed as follows:

          (i)     if to the Company, to:

                  Incara Pharmaceuticals Corporation
                  Post Office Box 14287
                  3200 East Highway 54
                  Cape Fear Building, Suite 300
                  Research Triangle Park, North Carolina 27709
                  Attention: Chief Executive Officer
                  Facsimile: (919) 544-1245

                  with a copy to:

                  Wyrick Robbins Yates & Ponton LLP
                  4101 Lake Boone Trail
                  Suite 300
                  Raleigh, North Carolina 27607
                  Attention: Larry Robbins
                  Facsimile: (919) 781-4865

          (ii)(a) if to EIS, to:

                  Elan International Services, Ltd.
                  102 St. James Court
                  Flatts, Smiths Parish
                  Bermuda FL 04
                  Attention: Chief Executive Officer
                  Facsimile: (441) 292-2224

              (b) if to EPIL, to:

                  Elan Pharma International Limited
                  Wil House
                  Shannon Business Park
                  Shannon, Co. Clare
                  Ireland
                  Attention: Secretary
                  Facsimile: 011-353-61-362097

          with a copy, in the case of (a) or (b) above, to:

                  Brock Silverstein LLC
                  800Third Avenue

                                       13
<PAGE>

               21/st/ Floor
               New York, NY 10022
               Attention: Kim E. Lefkowitz
               Facsimile: (212) 371-5500

or to such other address as the party to whom notice is to be given may have
furnished to the other party hereto in writing in accordance with provisions of
this Section 14(i). Any such notice or communication shall be deemed to have
been effectively given (i) in the case of personal or hand delivery, on the date
of such delivery, (ii) in the case of an internationally-recognized overnight
delivery courier, on the second business day after the date when sent, (iii) in
the case of mailing, on the fifth business day following that day on which the
piece of mail containing such communication is posted and (iv) in the case of
facsimile transmission, on the date of telephone confirmation of receipt.

          (j)  Entire Agreement. This Agreement constitutes the full and entire
               ----------------
understanding and agreement of the parties with regard to the subject matter
hereof and supersedes all prior agreements and understandings among the parties
with respect thereto.

                           [Signature page follows]

                                       14
<PAGE>

          IN WITNESS WHEREOF, the parties have executed this Registration Rights
Agreement as of the date first written above.

                               INCARA PHARMACEUTICALS CORPORATION

                               By: /s/ Clayton I. Duncan
                                   --------------------------------------------

                                   Name:  Clayton I. Duncan
                                   Title: President and Chief Executive Officer

                                   ELAN INTERNATIONAL SERVICES, LTD.

                               By: /s/ Kevin Insley
                                   --------------------------------------------
                                   Name:  Kevin Insley
                                   Title: President and Chief Financial Officer

                               ELAN PHARMA INTERNATIONAL LIMITED

                               By: /s/ Kevin Insley
                                   --------------------------------------------
                                   Name:  Kevin Insley
                                   Title: Authorized Signatory

                                       1EXHIBIT 10.1(d)

                                FOURTH AMENDMENT

              FOURTH AMENDMENT (this "Amendment"), dated as of January 26, 2001,
among ACG HOLDINGS, INC., a Delaware corporation ("Holdings"), AMERICAN COLOR
GRAPHICS, INC., a New York corporation (the "Borrower"), the lenders party to
the Credit Agreement referred to below (the "Lenders") and BANKERS TRUST
COMPANY, as Administrative Agent (in such capacity, the "Administrative Agent").
All capitalized terms used herein and not otherwise defined herein shall have
the respective meanings provided such terms in the Credit Agreement referred to
below.

                              W I T N E S S E T H :
                              - - - - - - - - - -

              WHEREAS, Holdings, the Borrower, the Lenders, General Electric
Capital Corporation, as Documentation Agent, Morgan Stanley Senior Funding,
Inc., as Syndication Agent, and the Administrative Agent are parties to a Credit
Agreement, dated as of August 15, 1995 and amended and restated as of May 8,
1998 (as so amended and restated and as the same has been further amended,
modified and/or supplemented to, but not including, the date hereof, the "Credit
Agreement"); and

              WHEREAS, the parties hereto wish to amend the Credit Agreement as
herein provided;

              NOW, THEREFORE, it is agreed:

              1. Section 8.12 of the Credit Agreement is hereby amended by (i)
inserting the text "this subclause (x) of" immediately prior to the text "this
clause (i)" appearing in the proviso in subclause (x) of clause (i) of said
Section and (ii) deleting the amount "$5,000,000" appearing in subclause (y) of
clause (i) of said Section and inserting the amount "$15,000,000" in lieu
thereof.

              2. In order to induce the Lenders to enter into this Amendment,
each of Holdings and the Borrower hereby represents and warrants that:

              (a) no Default or Event of Default exists as of the Fourth
         Amendment Effective Date (as defined below), both before and after
         giving effect to this Amendment;

              (b) all of the representations and warranties contained in the
         Credit Agreement or the other Credit Documents are true and correct in
         all material respects on the Fourth Amendment Effective Date both
         before and after giving effect to this Amendment, with the same effect
         as though such representations and warranties had been made on and as
         of the Fourth Amendment Effective Date (it being understood that any
         representation or

                                       24
<PAGE>

         warranty made as of a specific date shall be true and correct in all
         material respects as of such specific date);

              3. This Amendment is limited as specified and shall not constitute
a modification, acceptance or waiver of any other provision of the Credit
Agreement or any other Credit Document.

              4. This Amendment may be executed in any number of counterparts
and by the different parties hereto on separate counterparts, each of which
counterparts when executed and delivered shall be an original, but all of which
shall together constitute one and the same instrument. A complete set of
counterparts shall be lodged with the Borrower and the Administrative Agent.

              5. THIS AMENDMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES
HEREUNDER SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAW OF THE
STATE OF NEW YORK.

              6. This Amendment shall become effective on the date (the "Fourth
Amendment Effective Date") when Holdings, the Borrower, the Administrative Agent
and the Lenders constituting the Required Lenders shall have signed a
counterpart hereof (whether the same or different counterparts) and shall have
delivered (including by way of facsimile transmission) the same to the
Administrative Agent at its Notice Office.

              7. From and after the Fourth Amendment Effective Date, all
references in the Credit Agreement and each of the Credit Documents to the
Credit Agreement shall be deemed to be references to the Credit Agreement as
amended hereby.

                                      * * *

                                       25
<PAGE>

              IN WITNESS WHEREOF, each of the parties hereto has caused a
counterpart of this Amendment to be duly executed and delivered as of the date
first above written.

                                  ACG HOLDINGS, INC.

                                  By: /s/ Joseph M. Milano
                                     -----------------------------------------
                                     Name:  Joseph M. Milano
                                     Title: Executive Vice President and Chief
                                            Financial Officer

                                  AMERICAN COLOR GRAPHICS, INC.

                                  By: /s/ Joseph M. Milano
                                     -----------------------------------------
                                     Name:  Joseph M. Milano
                                     Title: Executive Vice President and Chief
                                            Financial Officer

                                  BANKERS TRUST COMPANY,
                                    Individually and as Administrative Agent

                                  By: /s/ Susan L. Le Fevre
                                     -----------------------------------------
                                     Name:  Susan L. Le Fevre
                                     Title: Director

                                  GENERAL ELECTRIC CAPITAL CORPORATION,
                                    Individually and as Documentation Agent

                                  By: /s/ Anne Kennelly Kratky
                                     -----------------------------------------
                                     Name:  Anne Kennelly Kratky
                                     Title: Manager-Operations

                                       26

<PAGE>

                                  MORGAN STANLEY SENIOR FUNDING, INC.,
                                    Individually and as Syndication Agent

                                  By: /s/ T.M. Edwards
                                     ------------------------------------
                                     Name:  T. Morgan Edwards II
                                     Title: Vice President

                                  CYPRESSTREE INVESTMENT
                                    MANAGEMENT COMPANY, INC.,
                                    as Attorney-in-Fact and on behalf of First
                                    Allmerica Financial Life Insurance Company,
                                    as Portfolio Manager

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  CYPRESSTREE INVESTMENT
                                    PARTNERS 1, LTD.,
                                    By: CypressTree Investment Management
                                    Company, Inc., as Portfolio Manager

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  DEUTSCHE FINANCIAL SERVICES CORPORATION

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                       27
<PAGE>

                                  FINOVA CAPITAL CORPORATION

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  FREMONT FINANCIAL CORPORATION

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  OAK HILL SECURITIES FUND, L.P.

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  PILGRIM AMERICA PRIME RATE TRUST
                                      By: Pilgrim America Investments, Inc.,
                                          as its Investment Manager

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                       28
<PAGE>

                                  PPM AMERICA SPECIAL INVESTMENTS FUND, L.P.
                                      By: PPM America, Inc.

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  PPM AMERICA SPECIAL INVESTMENTS CBO II, L.P.
                                      By: PPM America, Inc.

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  FLEET BUSINESS CREDIT CORPORATION

                                  By: /s/ Michael Kerneklian
                                     ------------------------------------
                                     Name:  Michael Kerneklian
                                     Title: Vice President

                                  TRANSAMERICA BUSINESS CREDIT CORPORATION

                                  By: /s/ Stephen Goetschius
                                     ------------------------------------
                                     Name:  Stephen Goetschius
                                     Title: Senior Vice President

                                       29
<PAGE>

                                  KZH CYPRESSTREE-1 LLC

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  KZH HIGHLAND-2 LLC

                                  By:
                                     ------------------------------------
                                     Name:
                                     Title:

                                  ORIX BUSINESS CREDIT, INC.

                                  By: /s/ Michael J. Cox
                                     ------------------------------------
                                     Name:  Michael J. Cox
                                     Title: Senior Vice President

                                  EMERALD ORCHARD LIMITED

                                  By: /s/ Susan K. Strong
                                     ------------------------------------
                                     Name:  Susan K. Strong
                                     Title: Attorney-in-Fact

                                  HIGHLAND LEGACY LIMITED
                                      By: Highland Capital Management, L.P.
                                          as Collateral Manager

                                  By: /s/ Mark K. Okada
                                     ------------------------------------
                                     Name:  Mark K. Okada CPA
                                     Title: Executive Vice President

                                       30

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00020-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00020-of-00352.parquet"}]]