Document:

Filed by Automated Filing Services Inc. (604) 609-0244 - Silverado Gold Mines Ltd. - Exhibit 10.

THIS WARRANT AND THE SECURITIES
TO BE ISSUED UPON ITS EXERCISE HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF
1933, AS AMENDED (THE “ACT”) AND HAVE BEEN
ISSUED IN RELIANCE UPON AN EXEMPTION
FROM THE REGISTRATION REQUIREMENT OF THE ACT
PROVIDED BY REGULATION S PROMULGATED
UNDER THE ACT. THIS WARRANT MAY NOT BE
EXERCISED BY OR ON BEHALF OF ANY U.S.
PERSON UNLESS REGISTERED
UNDER THE ACT OR AN EXEMPTION FROM
REGISTRATION IS AVAILABLE. THIS
WARRANT AND THE SECURITIES TO BE
ISSUED UPON ITS EXERCISE MAY NOT BE
REOFFERED FOR SALE OR RESOLD OR
OTHERWISE TRANSFERRED IN THE UNITED
STATES EXCEPT IN ACCORDANCE WITH THE
PROVISIONS OF REGULATION S, PURSUANT
TO AN EFFECTIVE REGISTRATION STATEMENT
UNDER THE ACT, OR PURSUANT TO AN
AVAILABLE EXEMPTION FROM REGISTRATION
UNDER THE ACT.THIS WARRANT AND THE
SECURITIES TO BE ISSUED UPON ITS
EXERCISE MAY BE RESOLD THROUGH
DESIGNATED OFFSHORE SECURITIES
MARKETS IN ACCORDANCE WITH THE
PROVISIONS OF REGULATION S. HEDGING
TRANSACTIONS INVOLVING THIS WARRANT OR
THE SECURITIES TO BE ISSUED UPON ITS
EXERCISE MAY NOT BE CONDUCTED UNLESS
IN COMPLIANCE WITH THE ACT. 

WARRANT CERTIFICATE NO.
_______________ 

SILVERADO GOLD MINES LTD.,

  A BRITISH COLUMBIA COMPANY 

  FORM OF COMMON SHARE PURCHASE WARRANT
  CERTIFICATE 

  ______________ , 2007 

THIS IS TO CERTIFY THAT for value,
  received , Name               ,
  Address                  ,  City      , 
  State  ,  Country        (the
  “Holder”), shall have the right to purchase from SILVERADO
  GOLD MINES LTD., a British Columbia company (the “Corporation”),
                               
  (NO. OF WARRANT SHARES ) fully paid and nonassessable
  common shares of the Corporation (the “Common Shares”), subject to
  further adjustment as set forth in Section 5 of the Terms and Conditions, at
  any time until 5:00 P.M., Pacific time, on the       Date     ,
  2007 (the “Expiration Date”) at an exercise price
  (the "Exercise Price") of $         
  US per share during the period from the date of issuance to the Expiration
  Date in accordance with the terms hereof and the Terms and Conditions set forth
  on the reverse of this Warrant Certificate, to which the Holder by acceptance
  of this Warrant Certificate agrees. 

IN WITNESS WHEREOF , the
Corporation has caused this Warrant Certificate to be duly executed and
delivered by its duly authorized officer. 

	  	SILVERADO GOLD MINES LTD. 
	  	  
	  	  
	  	  
	Attest: __________________________________________	By:  
      __________________________________________
	               
       John R. Mackay, Secretary 	           Garry
      L. Anselmo, President 

STATEMENT OF TERMS AND CONDITIONS 

1. Exercise of Warrants. This Warrant is exercisable in
whole or in partial allotments of no less than 1,000 shares at the Exercise
Price per share of Common Shares payable hereunder, payable in cash or by
certified or official bank check. Upon surrender of this Warrant Certificate
with the annexed Notice of Exercise Form duly executed, together with payment of
the Exercise Price for the shares of Common Shares purchased, the Holder shall
be entitled to receive a certificate or certificates for the shares of Common
Shares so purchased. Payment of the aggregate Exercise Price must be made in
cash or certified funds. No fractional shares shall be issued in connection with
any exercise of this Warrant. In lieu of the issuance of any fractional share,
the Corporation shall make a cash payment equal to the then fair market value of
such fractional share as determined by the Corporation’s Board of Directors.

2. Reservation of Shares. The Corporation hereby agrees
that at all times during the term of this Warrant there shall be reserved for
issuance upon exercise of this Warrant such number of shares of its Common
Shares as shall be required for issuance upon exercise of this Warrant (the
“Warrant Shares”). 

3. Mutilation or Loss of Warrant. Upon receipt by the
Corporation of evidence satisfactory to it of the loss, theft, destruction or
mutilation of this Warrant, and (in the case of loss, theft or destruction)
receipt of reasonably satisfactory indemnification, and (in the case of
mutilation) upon surrender and cancellation of this Warrant, the Corporation
will execute and deliver a new Warrant of like tenor and date and any such lost,
stolen, destroyed or mutilated Warrant shall thereupon become void. 

4. Rights of the Holder. The Holder shall not, by virtue
hereof, be entitled to any rights of a stockholder in the Corporation, either at
law or equity, and the rights of the Holder are limited to those expressed in
this Warrant and are not enforceable against the Corporation except to the
extent set forth herein. 

5. Protection Against Dilution. The Exercise Price and
the number of shares which can be purchased by the Holder upon the exercise of
this Warrant shall be subject to adjustment in the events and in the manner
following: (1) If and whenever the shares at any time outstanding shall be
subdivided into a greater or consolidated into a lesser number of shares, the
Exercise Price shall be decreased or increased proportionately as the case may
be; upon any such subdivision or consolidation, the number of shares which can
be purchased upon the exercise of this warrant certificate shall be increased or
decreased proportionately as the case may be. (2) In case of any capital
reorganization or of any reclassification of the capital of the Corporation or
in case of the consolidation, merger or amalgamation of the Corporation with or
into any other company, this Warrant shall after such capital reorganization,
reclassification of capital, consolidation, merger or amalgamation confer the
right to purchase the number of shares or other securities of the Corporation or
of the Corporation resulting from such capital reorganization, reclassification,
consolidation, merger or amalgamation, as the case may be, to which the Holder
of the shares deliverable at the time of such capital reorganization,
reclassification of capital, consolidation, merger or amalgamation, upon the
exercise of this Warrant would have been entitled. On such capital
reorganization, reclassification, consolidation, merger or amalgamation
appropriate adjustments shall be made in the application of the provisions set
forth herein with respect to the rights and interest thereafter of the Holder of
this Warrant so that the provisions set forth herein shall thereafter be
applicable as nearly as may reasonably be in relation to any shares or other
securities thereafter deliverable on the exercise of this Warrant. (3) The
rights of the Holder evidenced hereby are to purchase shares prior to or on the
date set out on the face of this Warrant. If there shall, prior to the exercise
of any of the rights evidenced hereby, be any reorganization of the authorized
capital of the Corporation by way of consolidation, merger, subdivision,
amalgamation or otherwise, or the payment of any stock dividends, then there
shall automatically be an adjustment in either or both of the number of shares
which may be purchased pursuant hereto or the price at which such shares may be
purchased so that the rights evidenced hereby shall thereafter as reasonably as
possible be equivalent to those originally granted hereby. The Corporation shall
have the sole and exclusive power to make such adjustments as it considers
necessary and desirable. (4) The adjustments provided for herein in the
subscription rights represented by this Warrant are cumulative. 

6. Transfer to Comply with the Securities Act of 1933, as
amended, and Other Applicable Securities Legislation. This Warrant and the
Warrant Shares have not been registered under the Securities Act of 1933, as
amended, (the "Act") and have been issued to the Holder pursuant to Regulation S
of the Act on the representations of the Holder in a subscription agreement
executed by the Holder in favor of the Corporation. Neither this Warrant nor any
of the Warrant Shares or any other security issued or issuable upon exercise of
this Warrant may be sold, transferred, pledged or hypothecated in the absence of
an effective registration statement under the Act relating to such security or
an opinion of counsel reasonably satisfactory to the Corporation that
registration is not required under the Act. Each certificate for the Warrant,
the Warrant Shares and any other security issued or issuable upon exercise of
this Warrant shall contain a legend on the face thereof, in form and substance
satisfactory to counsel for the Corporation, setting forth the restrictions on
transfer contained in this Section. By acceptance of this certificate, the
Holder acknowledges and agrees that: (1) The Holder will only sell the Warrants
and the shares issuable upon exercise of the Warrants (the “Warrant Shares")
only in accordance with the provisions of Regulation S of the Act, pursuant to
registration under the Act, or pursuant to an available exemption from
registration pursuant to the Act; (2) The Corporation will refuse to register
any transfer of the Warrants and the Warrant Shares not made in accordance with
the provisions of Regulation S of the Act, pursuant to registration under the
Act, or pursuant to an available exemption from registration; (3) The Holder
will not engage in hedging transactions except in accordance with the Act. All
certificates representing the Warrant Shares will be endorsed with the following
legend: 

“The Securities Represented By This Certificate Have Not
Been Registered Under The Securities Act Of 1933, as amended (The "Act"), And
Have Been Issued In Reliance Upon An Exemption From The Registration
Requirements Of The Act Provided By Regulation S Promulgated Under The Act. Such
Securities May Not Be Reoffered For Sale Or Resold Or Otherwise Transferred
Except In Accordance With The Provisions Of Regulation S, Pursuant To An
Effective Registration Under The Act, Or Pursuant To An Available Exemption From
Registration Under The Act. Hedging Transactions Involving The Securities May
Not Be Conducted Unless In Compliance With The Act.” 

In addition, the Holder will comply with all other applicable
securities legislation in addition to the Act to which the Holder is subject in
selling or transferring any Warrants or Warrant Shares and the Corporation may
refuse to register any sale or transfer not in compliance with such other
securities legislation. 

7. Payment of Taxes. The Corporation shall not be
required to pay any tax or other charge imposed in connection with the exercise
of this Warrant or a permissible transfer involved in the issuance of any
certificate for shares issuable under this Warrant in the name other than that
of the Holder, and in any such case, the Corporation shall not be required to
issue or deliver any stock certificate until such tax or other charge has been
paid or it has been established to the Corporation’s satisfaction that no such
tax or other charge is due. 

8. Notices. Any notice required or permitted hereunder
shall be given in writing and shall be deemed effectively given upon, (a) by
personal delivery or telecopy, or (ii) one business day after deposit with a
nationally recognized overnight delivery service such as Federal Express, with
postage and fees prepaid, addressed to each of the other parties thereunto
entitled at the following addresses, or at such other addresses as a party may
designate by written notice to each of the other parties hereto. 

HOLDER: At the address set forth
above.; CORPORATION: SILVERADO GOLD MINES LTD.,
Attn: Mr. Garry L. Anselmo, President, Suite 1820, 1111 W. Georgia St.,
Vancouver, BC, Canada V6E 4M3, Fax: 604-682-3519; with a copy to: RICHARDSON
& PATEL LLP, Attn: Mr. Mark Abdou, 10900 Wilshire Boulevard, Suite 500, Los
Angeles, CA, USA 90024, Fax: (310) 208-1182. 

9. Governing Law. This Warrant shall be deemed to be a
  contract made under the laws of the Province of British Columbia and for all
  purposes shall be governed by and construed in accordance with the laws of the
  Province of British Columbia applicable to contracts to be made and performed
  entirely within the Province of British Columbia. 

EXERCISE FORM 

TO: SILVERADO GOLD MINES LTD., A British Columbia
company (the “Corporation”) 

The undersigned Holder of the foregoing Warrant (the
“Subscriber”) hereby exercises the right to purchase and hereby subscribes for
the number of common shares of SILVERADO GOLD MINES LTD. set forth below (the
“Warrant Shares”) in accordance with the Terms and Conditions of this Warrant
Certificate and hereby makes payment by cash, certified check or bank draft of
the purchase price in full for the Warrant Shares. Please deliver a warrant
certificate in respect of the warrants referred to in the Warrant Certificate
surrendered herewith but not presently subscribed for to the Subscriber. 

The Subscriber represents and warrants to the Corporation that:

     1. The Subscriber is not a “U.S.
Person” as defined by Regulation S of the Securities Act of 1933, as amendee
(the “Act”) and is not exercising the Warrant or acquiring the Warrant Shares
for the account or benefit of a U.S. Person. 

     2. The Subscriber was not in the
United States at the time the Warrant was exercised or acquired.

     3. The Subscriber acknowledges
that the Warrant Shares are “restricted securities” within the meaning of the
Act and will be issued to the Subscriber in accordance with Regulation S of the
Act. 

     4. The Subscriber agrees not to
engage in hedging transactions with regard to the Warrant Shares unless in
compliance with the Act. 

     5. The Subscriber agrees that the
Corporation will refuse to register any transfer of the Warrant Shares not made
in accordance with the provisions of Regulation S of the Act, pursuant to
registration under the Act, pursuant to an available exemption from
registration, or pursuant to this Agreement. The Subscriber acknowledges that
the Subscriber has no right to require the Corporation to register the Warrant
Shares under the Act. 

     6. The Subscriber agrees to
resell the Warrant Shares only in accordance with the provisions of Regulation S
of the Act, pursuant to registration under the Act, or pursuant to an available
exemption from registration pursuant to the Act.

     7. The Subscriber acknowledges
that any exercise of this Warrant requires a written opinion of counsel to the
effect that the Warrant and the securities delivered upon exercise thereof have
been registered under the Act or are exempt from registration thereunder. 

     8. The Subscriber acknowledges
and agrees that all certificates representing the Warrant Shares will be
endorsed with the legend required by the Terms and Conditions specified by the
Warrant Certificate.

DATED this __________ day of ____________________________,
_____________________. 

Number of Shares Subscribed For:     
  _________________________________________________________________________________

Signature of Subscriber:                       
  _________________________________________________________________________________

Name of Subscriber (please print):      
  _________________________________________________________________________________

Address of Subscriber:                         
  _________________________________________________________________________________Filed by Automated Filing Services Inc. (604) 609-0244 -  Medicure Inc. - Exhibit 4.1

MEDICURE INC. 

STOCK OPTION PLAN 
Amended and
Restated as of October 2, 2007 

	1. 	
      Purpose. The purpose of the Stock Option Plan (the
      “Plan”) of Medicure Inc. (the “Corporation”), a Corporation
      incorporated under the federal laws of Canada, is to advance the interests
      of the Corporation by encouraging its directors, management, consultants
      and employees to acquire shares in the Corporation, thereby increasing
      their proprietary interest in the Corporation, encouraging them to remain
      associated with the Corporation and furnishing them with additional
      incentive in their efforts on behalf of the Corporation in the conduct of
      its affairs.

	 	 
	2. 	
      Administration. The Plan shall be administered by
      the board of directors of the Corporation (the “Board”).

	 	 
		
      Subject to the provisions of the Plan, the Board shall
      have authority to construe and interpret the Plan and all Option
      Agreements entered into thereunder, to define the terms used in the Plan
      and in all Option Agreements entered into thereunder, to prescribe, amend
      and rescind rules and regulations relating to the Plan, subject to any
      necessary regulatory approvals of the Toronto Stock Exchange
      (“TSX”), and to make all other determinations necessary or
      advisable for the administration of the Plan. All determinations and
      interpretations made by the Board shall be binding and conclusive on all
      participants in the Plan and on their legal personal representatives and
      beneficiaries.

	 	 
		
      Each option granted hereunder (an “Option”)
      shall be evidenced by an agreement (an “Option Agreement”), signed
      on behalf of the Corporation and by the optionee, in such form as the
      directors shall approve. Each such agreement shall recite that it is
      subject to the provisions of this Plan.

	 	 
	3. 	
      Shares Subject to Plan. Subject to adjustment as
      provided in Section 14 hereof, the shares to be offered under the Plan
      shall consist of common shares of the Corporation (“Shares”) which
      shall be issued from treasury for purposes of the Plan. The aggregate
      number of Shares that may be reserved for issuance at any time pursuant to
      Options granted under this Plan shall not exceed 10% of the total number
      of Shares issued and outstanding at the date of any grant made hereunder.
      Any exercise of an Option granted under the Plan will result in an
      additional grant being available under the Plan. If any Option shall
      expire or terminate for any reason without having been exercised in full,
      the unpurchased Shares subject thereto shall again be available for the
      purpose of this Plan.

	 	 
	4. 	
      Maintenance of Sufficient Capital. The Corporation
      shall at all times during the term of this Plan reserve and keep available
      such numbers of Shares as will be sufficient to satisfy the requirements
      of the Plan.

	5. 	
      Eligibility and Participation. Directors,
      officers, management, consultants and employees of the Corporation shall
      be eligible for selection to participate in the Plan (such persons
      hereinafter collectively referred to as “Participants”). The Board
      shall determine to whom Options shall be granted, the terms and provisions
      of the respective Option Agreements, the time or times at which such
      Options shall be granted, and the number of Shares to be subject to each
      Option. An individual who has been granted an Option may, if he is
      otherwise eligible, and if permitted under the policies of the stock
      exchange or stock exchanges on which the Shares are to be listed, be
      granted an additional Option or Options if the directors shall so
      determine.

	 	 	 
	6. 	
      Exercise Price

	 	 	 
		(a) 	
      The exercise price of the Shares covered by each Option
      shall be determined by the Board. Subject to the provisions of Section
      6(b), the exercise price shall be not less than the closing price of the
      Shares on the primary stock exchange on which the Shares are listed on the
      last trading day immediately preceding the day on which the Option is
      granted.

	 	 	 
		(b) 	
      If an Option is granted within six months of a public
      distribution of the Shares by way of prospectus, then the minimum exercise
      price of such Option shall, if the policy of such stock exchange or stock
      exchanges requires, be the greater of the price determined pursuant to
      Section 6(a) and the price per Share paid by the investing public for
      Shares acquired by the public during such public distribution, determined
      in accordance with the policy of such stock exchange or stock
      exchanges.

	 	 	 
	7. 	
      Number of Optioned Shares.

	 	 	 
		(a) 	
      The number of Shares issuable to Insiders, at any time,
      under all security based compensation arrangements, cannot exceed 10% of
      the issued and outstanding Shares.

	 	 	 
		(b) 	
      The number of Shares issued to Insiders, within any one
      year period, under all security based compensation arrangements, cannot
      exceed 10% of the issued and outstanding Shares.

	 	 	 
		(c) 	
      “Insider” means any insider of the Corporation (as
      such term is defined in subsection 1(1) of the Securities Act
      (Ontario) as amended from time to time), other than a person who falls
      within that definition solely by virtue of being a director or officer of
      a subsidiary of the Corporation, and includes any “associate” of any
      insider (as such term is defined in the said subsection as amended from
      time to time).

	8. 	
      Duration of Option.

	 	 	 
		(a) 	
      Each Option and all rights thereunder shall be expressed
      to expire on the date set out in the Option Agreements and shall be
      subject to earlier termination as provided in paragraphs 10 and
  11.

	 	 	 
		(b) 	
      Notwithstanding any other provision of this Plan, no
      Option shall terminate, become void and of no effect or cease to be
      exercisable, whether as a result of the expiry of the term fixed for
      exercise of the Option or as a result of the termination or cessation of
      employment of an optionee, prior to 5:00 p.m. (Toronto time) on the tenth
      business day following the cessation of any Trading Blackout applicable to
      such optionee in effect at the time such Option would otherwise expire or
      terminate or if a Trading Blackout is not then in effect, prior to 5:00
      p.m. (Toronto time) on the tenth business day following cessation of the
      most recent Trading Blackout applicable to such optionee prior to the
      Expiry Date.

	 	 	 
		(c) 	
      “Trading Blackout” means any restricted trading
      period imposed by the Corporation during which the directors and officers
      of the Corporation and specified employees are prohibited from trading in
      the securities of the Corporation.

	 	 	 
	9. 	
      Option Period, Consideration and
Payment.

	 	 	 
		(a) 	
      The Option Period shall be a period of time fixed by the
      Board, not to exceed ten years from the date the Option is granted,
      provided that the Option Period shall be reduced with respect to any
      Option as provided in Sections 10 and 11 covering cessation as a director,
      officer, consultant or employee of the Corporation or death of the
      Participant.

	 	 	 
		(b) 	
      An Option shall vest and may be exercised (in each case
      to the nearest full Share) during the Option Period in such manner as the
      Board may fix by resolution. Options which have vested may be exercised in
      whole or in part at any time and from time to time during the Option
      Period.

	 	 	 
		(c) 	
      Except as set forth in Section 10 and 11, no Option may
      be exercised unless the Participant is at the time of such exercise a
      director, officer, manager, consultant, or employee of the Corporation. In
      the case of a consultant, where the Option has been granted for a specific
      service, the Option may be exercised only upon completion of that
      service.

	 	 	 
		(d) 	
      The exercise of any Option will be contingent upon
      receipt by the Corporation at its head office of a written notice of
      exercise, specifying the number of Shares with respect to which the Option
      is being exercised, accompanied by cash payment, certified cheque or bank
      draft for the full purchase price of such Shares with respect to which the
      Option is exercised. No Participant or his
legal

			representatives, legatees or distributes will be, or
      will deemed to be, a holder of any Shares subject to an Option under this
      Plan, unless and until the certificate for such Shares are issued to him
      or them under the terms of the Plan.
	 	 	 
	10. 	
      Ceasing to Be a Director, Consultant, Officer,
      Manager, Consultant or Employee.

	 	 	 
		
      If a Participant shall cease to be a director, officer,
      manager, consultant or employee of the Corporation or a company for any
      reason (other than death), he may, but only within the earlier of the
      original expiry date and 90 days next succeeding his ceasing to be a
      director, officer, manager, consultant, or employee, exercise his Option
      to the extent that he was entitled to exercise it at the date of such
      cessation.

	 	 	 
		
      Nothing contained in the Plan, nor in any Option granted
      pursuant to the Plan, shall as such confer upon any Participant any right
      with respect to continuance as a director, officer, manager, consultant or
      employee of the Corporation or of any affiliate.

	 	 	 
	11. 	
      Death of Participant. In the event of the death of
      a Participant, the Option previously granted to him shall be exercisable
      only by the earlier of the original expiry date and the date that is
      twelve months after the date of death and then only:

	 	 	 
		(a) 	
      by the person or persons to whom the Participant’s rights
      under the Option shall pass by the Participant’s will or the laws of
      descent and distribution; and

	 	 	 
		(b) 	
      if and to the extent that he was entitled to exercise the
      Option at the date of his death.

	 	 	 
	12. 	
      Right of Optionee. No person entitled to exercise
      any Option granted under the Plan shall have any of the rights or
      privileges of a shareholder of the Corporation in respect of any Shares
      issuable upon exercise of such Option until certificates representing such
      Shares shall have been issued and delivered.

	 	 	 
	13. 	
      Proceeds from Sales of Shares. The proceeds from
      sales of Shares issued upon the exercise of Options shall be added to the
      general funds of the Corporation and shall thereafter be used from time to
      time for such corporate purposes as the Board may determine and
    direct.

	 	 	 
	14. 	
      Adjustments. If the outstanding Shares of the
      Corporation are increased, decreased, changed into or exchanged for a
      different number or kind of shares of securities of the Corporation
      through re-organization, merger, re-capitalization, re-classification,
      stock dividend, subdivision or consolidation, an appropriate and
      proportionate adjustment shall be made in the maximum number of kind of
      shares as to which Options may be granted under the Plan. A corresponding
      adjustment changing the number or kind of shares allocated to unexercised
      Options or portions thereof, which shall have been granted prior to any
      such change, shall likewise be made. Any such adjustment in the
      outstanding Options shall be made without change in the aggregate purchase
      price applicable to the

unexercised portion of the Option but
with a corresponding adjustment in the price for each share or other unit of any
security covered by the Option. 

Upon the liquidation or dissolution of
the Corporation or upon a re-organization, merger or consolidation of the
Corporation with one or more corporations as a result of which the Corporation
is not the surviving corporation, or upon the sale of substantially all of the
property or more than eighty (80%) percent of the then outstanding Shares of the
Corporation to another corporation, the Plan shall terminate, and any Options
theretofore granted hereunder shall terminate unless provision is made in
writing in connection with such transaction for the continuance of the Plan and
for the assumption of Options theretofore granted, or the substitution for such
Options of new options covering the shares of a successor employer corporation,
or a parent or subsidiary thereof, with appropriate adjustments as to number and
kind of shares and prices, in which event the Plan and Options theretofore
granted shall continue in the manner and upon the terms so provided. If the Plan
and outstanding Options shall terminate pursuant to the foregoing sentence, then
immediately prior to consummation of the event which results in the termination
of the Plan and outstanding Options, the Board may determine that all of the
Options of an optionee vest and become exercisable for such period as the Board
specifies. Options not exercised within the specified period will terminate.

Adjustments under this Section shall be
made by the Board, subject to the approval of the primary stock exchange on
which the shares of the Corporation are listed, whose determination as to what
adjustments shall be made, and the extent thereof, shall be final, binding and
conclusive. No fractional share shall be issued under the Plan on any such
adjustment. 

14.1 Change of Control. If a
bona fide offer (the “Offer”) for voting or equity shares is made to
shareholders of the Corporation generally, or to a class of shareholders of the
Corporation which, if Options were exercised, would include the Participants,
and which Offer, if accepted in whole or in part, would result in the offeror
exercising control over the Corporation within the meaning of subsection 1(3) of
the Securities Act (Ontario) then, notwithstanding Sections 8 and 9 but
subject to the other provisions hereof: 

	 	(a) 	
      The Board may give its express consent to the exercise of
      any Options which are outstanding although not yet exercisable at the time
      of the Offer in the manner hereinafter provided.

	 	 	 
	 	(b) 	
      If the Board has so consented to the exercise of any
      Options outstanding at the time of the Offer, the Corporation shall,
      immediately after such consent has been given, notify each Participant
      currently holding an Option of the Offer, with full particulars thereof,
      together with a notice stating that, in order to permit the Participant to
      participate in the Offer, the Participant may, during the period that the
      Offer is open for acceptance (or, if no such period is specified, the
      period of 30 days following the date

	 		
      of such notice), exercise all or any portion of any such
      Option held by the Participant.

	 	 	 	 
	 	(c) 	
      In the event that the Participant so exercises any such
      Option, such exercise shall be in accordance with Sections 6, 7 and 9(d)
      hereof; provided that, if necessary in order to permit the Participant to
      participate in the Offer, such Option shall be deemed to have been
      exercised, and the issuance of Shares received upon such exercise (the
      “Optioned Shares”) shall be deemed to have occurred, effective as
      of the first day prior to the date on which the Offer was made.

	 	 	 	 
	 	(d) 	
      If, upon the expiry of the applicable period referred to
      in subsection (b) above, the Offer is completed, and:

	 	 	 	 
	 		(i) 	
      the Participant has not exercised the entire or any
      portion of such Option then, as of and from the expiry of such period, the
      Participant’s right to purchase the Shares covered by such Option shall
      not be exercisable, and shall expire and be null and void; and

	 	 	 	 
	 		(ii) 	
      the Participant has exercised the entire or any portion
      of such Option, but has not tendered the Shares received in connection
      with such exercise to the Offer, then, as and from the expiry of such
      period, the Corporation may require the Participant to sell to the
      Corporation such Optioned Shares for a purchase price of $.001 per
      Optioned Share.

	 	 	 	 
	 	(e) 	
      If:

	 	 	 	 
	 		(i) 	
      the Offer is not completed (within the time specified
      therein, if applicable);

	 	 	 	 
	 			
      or

	 	 	 	 
	 		(ii) 	
      all of the Optioned Shares tendered by the Participant
      pursuant to the Offer are not taken up and paid for by the offeror in
      respect thereof;

	 	 	 	 
	 		
      then the Optioned Shares or, in the case of paragraph
      (ii) above, the portion thereof that is not taken up and paid for by such
      offeror, shall be returned by the Holder to the Corporation for
      cancellation and the terms of the Option as set forth herein shall again
      apply to such Option, or the remaining portion thereof, as the case may
      be.

	 	 	 	 
	 	(f) 	
      If any Optioned Shares are returned to the Corporation
      pursuant to subsection (e) above, the Corporation shall refund the Option
      price to the Participant in respect of such Optioned
  Shares.

		
       
	(g) 	
       In no event shall the Participant be entitled to
      sell the Optioned Shares otherwise than pursuant to the Offer, except as
      provided in paragraph (d)(ii) above.

	 	 	 
	15. 	
      Transferability. All benefits, rights and Options
      accruing to any Participant in accordance with the terms and conditions of
      the Plan shall not be transferable or assignable unless specifically
      provided herein. During the lifetime of a Participant any benefits, rights
      and Options may only be exercised by the Participant.

	 	 	 
	16. 	
      Amendment and Termination of Plan.

	 	 	 
		(a) 	
      The Board may, at any time, suspend or terminate the Plan
      or amend or revise the terms of the Plan, provided that no such amendment
      or revisions shall alter the terms of any Options theretofore granted
      under the Plan. Subject to Section 16(b) and subject to any necessary
      approval of the TSX or any other Stock Exchange on which the Shares may be
      listed, the Board may, from time to time, and without the approval of the
      Company’s shareholders: (i) amend the Plan and the terms and the
      conditions of any Options thereafter to be granted; and (ii) with the
      consent of the affected holder of an Option, amend the Plan and the terms
      and conditions of any Options which have been theretofore
  granted.

	 	 	 
		(b) 	
      The shareholders of the Company shall approve any
      amendment to the Plan or any Option which (i) reduces the exercise price
      of an Option granted to an Insider; (ii) extends the period
      available to exercise an Option granted to an Insider other than as
      provided in Section 8(b); or (iii) increases the number of shares reserved
      for issuance under the Plan (other than pursuant to the provisions of
      Section 14 hereof).

	 	 	 
	17. 	
      Necessary Approvals. The obligation of the
      Corporation to issue and deliver Shares in accordance with the Plan is
      subject to any approvals which may be required from any regulatory
      authority or stock exchange having jurisdiction over the securities of the
      Corporation. If any Shares cannot be issued to any Participant for
      whatever reason, the obligation of the Corporation to issue such Shares
      shall terminate and any Option exercise price paid to the Corporation will
      be returned to the Participant.

	 	 	 
	18. 	
      Stock Exchange Rules. The rules of any stock
      exchange upon which the Corporation’s Shares are listed shall be
      applicable relative to Options granted to Participants.

	 	 	 
	19. 	
      Effective Date of Plan. The Plan has been adopted
      by the Board of the Corporation subject to the approval of the stock
      exchange or stock exchanges on which the Shares of the Corporation are to
      be listed and, if so approved, the Plan shall became effective upon such
      approvals being obtained.

	20. 	
      Interpretation. The Plan will be governed by and
      construed in accordance with the laws of
Canada.

	 	MEDICURE INC. 
	 	 
	 	Per: 	/s/ Albert D. Friesen 
	 	 	 
	 	Per: 	/s/ Derek Reimer

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