Document:

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                                                                     EXHIBIT 4.2

THIS WARRANT AND THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE OFFERED, SOLD,
ASSIGNED OR TRANSFERRED, IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT
UNDER SAID ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL
REASONABLY SATISFACTORY TO THE COMPANY THAT REGISTRATION UNDER SAID ACT IS NOT
REQUIRED.

                                                                  Warrant No. W-

                          COMMON STOCK PURCHASE WARRANT

                       To Purchase ____________ Shares of
                            Common Stock of SPECTRUM
                              PHARMACEUTICALS, INC.

         THIS IS TO CERTIFY THAT _______________, or registered assigns (the
"Holder"), is entitled, during the Exercise Period (as hereinafter defined), to
purchase from Spectrum Pharmaceuticals, Inc., a Delaware corporation (the
"Company"), the Warrant Stock (as hereinafter defined and subject to adjustment
as provided herein), in whole or in part, at a purchase price of $10.00 per
share, all on and subject to the terms and conditions hereinafter set forth.

         1. Definitions. As used in this Warrant, the following terms have the
respective meanings set forth below:

         "Affiliate" means any person or entity that, directly or indirectly
through one or more intermediaries, controls or is controlled by or is under
common control with a person or entity, as such terms are used in and construed
under Rule 144 under the Securities Act. With respect to a Holder of Warrants,
any investment fund or managed account that is managed on a discretionary basis
by the same investment manager as such Holder will be deemed to be an Affiliate
of such Holder.

         "Appraised Value" means, in respect of any share of Common Stock on any
date herein specified, the fair saleable value of such share of Common Stock
(determined without giving effect to the discount for (i) a minority interest or
(ii) any lack of liquidity of the Common Stock or to the fact that the Company
may have no class of equity registered under the Exchange Act) as of the last
day of the most recent fiscal month ending prior to such date specified, based
on the value of the Company on a fully-diluted basis, as determined by a
nationally recognized investment banking firm selected by the Company's Board of
Directors and having no prior relationship with the Company.

         "Business Day" means any day except Saturday, Sunday and any day which
shall be a legal holiday or a day on which banking institutions in the State of
California generally are authorized or required by law or other government
actions to close.
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         "Change of Control" means the (i) acquisition by an individual or legal
entity or group (as set forth in Section 13(d) of the Exchange Act) of more than
one-half of the voting rights or equity interests in the Company; or (ii) sale,
conveyance, or other disposition of all or substantially all of the assets,
property or business of the Company or the merger into or consolidation with any
other corporation (other than a wholly owned subsidiary corporation) or
effectuation of any transaction or series of related transactions where holders
of the Company's voting securities prior to such transaction or series of
transactions fail to continue to hold at least 50% of the voting power of the
Company (or, if other than the Company, the successor or acquiring entity)
immediately following such transaction.

         "Closing Date" means April 21, 2004.

         "Commission" means the Securities and Exchange Commission or any other
federal agency then administering the Securities Act and other federal
securities laws.

         "Common Stock" means (except where the context otherwise indicates) the
Common Stock, $0.001 par value per share, of the Company as constituted on the
Closing Date, and any capital stock into which such Common Stock may thereafter
be changed or converted, and shall also include (i) capital stock of the Company
of any other class (regardless of how denominated) issued to the holders of
shares of Common Stock upon any reclassification thereof which is also not
preferred as to dividends or assets on liquidation over any other class of stock
of the Company and which is not subject to redemption and (ii) shares of common
stock of any successor or acquiring corporation received by or distributed to
the holders of Common Stock of the Company in the circumstances contemplated by
Section 4.3.

         "Current Market Price" means, in respect of any share of Common Stock
on any date herein specified,

         (1) if there shall not then be a public market for the Common Stock,
the higher of

                  (a) the book value per share of Common Stock at such date, and

                  (b) the Appraised Value per share of Common Stock at such
         date,

         or

         (2) if there shall then be a public market for the Common Stock, the
average of the daily market prices for the five (5) consecutive trading days
immediately preceding such date. The daily market price for each such trading
day shall be (i) the closing bid price on such day on the principal stock
exchange (including the NASDAQ Stock Market) on which such Common Stock is then
listed or admitted to trading, or quoted, as applicable, (ii) if no sale takes
place on such day on any such exchange, the last reported closing bid price on
such day as officially quoted on any such exchange (including the NASDAQ Stock
Market), (iii) if the Common Stock is not then listed or admitted to trading on
any stock exchange, the last reported closing bid price on such day in the
over-the-counter market, as furnished by the National Association of Securities
Dealers Automatic Quotation System or the National Quotation Bureau, Inc., (iv)
if neither such corporation at the time is engaged in the business of reporting
such prices, as furnished by any similar firm then engaged in such business, or
(v) if there is no such firm, as

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furnished by any member of the NASD selected mutually by the holder of this
Warrant and the Company or, if they cannot agree upon such selection, as
selected by two such members of the NASD, one of which shall be selected by
holder of this Warrant and one of which shall be selected by the Company.

         "Current Warrant Price" means, in respect of a share of Common Stock at
any date herein specified, the price at which a share of Common Stock may be
purchased pursuant to this Warrant on such date. Unless and until the Current
Warrant Price is adjusted pursuant to the terms herein, the initial Current
Warrant Price shall be $10.00 per share of Common Stock.

         "Exchange Act" means the Securities Exchange Act of 1934, as amended,
or any similar federal statute, and the rules and regulations of the Commission
thereunder, all as the same shall be in effect from time to time.

         "Exercise Period" means the period during which this Warrant is
exercisable pursuant to Section 2.1.

         "Expiration Date" means April 20, 2009.

         "GAAP" means generally accepted accounting principles in the United
States of America as from time to time in effect.

         "NASD" means the National Association of Securities Dealers, Inc., or
any successor corporation thereto.

         "Other Property" has the meaning set forth in Section 4.3.

         "Person" means any individual, sole proprietorship, partnership, joint
venture, trust, incorporated organization, association, corporation, limited
liability company, institution, public benefit corporation, entity or government
(whether federal, state, county, city, municipal or otherwise, including,
without limitation, any instrumentality, division, agency, body or department
thereof).

         "Purchase Agreement" means that certain Common Stock and Warrant
Purchase Agreement dated as of April 20, 2004 among the Company and the other
parties named therein, pursuant to which this Warrant was originally issued.

         "Restricted Common Stock" means shares of Common Stock which are, or
which upon their issuance upon the exercise of any Warrant would be required to
be, evidenced by a certificate bearing the restrictive legend set forth in
Section 3.2.

         "Securities Act" means the Securities Act of 1933, as amended, or any
similar federal statute, and the rules and regulations of the Commission
thereunder, all as the same shall be in effect at the time.

         "Trading Day" means any day on which the primary market on which shares
of Common Stock are listed is open for trading.

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         "Transfer" means any disposition of any Warrant or Warrant Stock or of
any interest in either thereof, which would constitute a sale thereof within the
meaning of the Securities Act.

         "Warrants" means this Warrant and all warrants issued upon transfer,
division or combination of, or in substitution for, any thereof. All Warrants
shall at all times be identical as to terms and conditions and date, except as
to the number of shares of Common Stock for which they may be exercised.

         "Warrant Price" means an amount equal to (i) the number of shares of
Common Stock being purchased upon exercise of this Warrant pursuant to Section
2.1, multiplied by (ii) the Current Warrant Price.

         "Warrant Stock" means the ____________ shares of Common Stock to be
purchased upon the exercise hereof, subject to adjustment as provided herein.

         2. Exercise of Warrant.

         2.1. Manner of Exercise. From and after the first anniversary of the
Closing Date, and until 5:00 P.M., New York time, on the Expiration Date (the
"Exercise Period"), the Holder may exercise this Warrant, on any Business Day,
for all or any part of the number of shares of Warrant Stock purchasable
hereunder.

         In order to exercise this Warrant, in whole or in part, the Holder
shall deliver to the Company at its principal office or at the office or agency
designated by the Company as described in Section 10, (i) a written notice of
Holder's election to exercise this Warrant, which notice shall specify the
number of shares of Warrant Stock to be purchased, and which notice shall be
substantially in the form of the subscription form appearing at the end of this
Warrant as Exhibit A, duly executed by the Holder or its agent or attorney, (ii)
an investment representation letter in form and substance acceptable to the
Company and substantially in the form attached as Exhibit C executed by the
Holder, (iii) payment of the Warrant Price as provided herein and (iv) this
Warrant. Upon receipt thereof, the Company shall, as promptly as practicable,
and in any event within three Business Days thereafter, execute or cause to be
executed and deliver or cause to be delivered to the Holder a certificate or
certificates representing the aggregate number of full shares of Warrant Stock
issuable upon such exercise, together with cash in lieu of any fraction of a
share, as hereinafter provided. The stock certificate or certificates so
delivered shall be, to the extent possible, in such denomination or
denominations as the Holder shall request in the notice and shall be registered
in the name of the Holder or if permitted pursuant to the terms of this Warrant
such other name as shall be designated in the notice. This Warrant shall be
deemed to have been exercised and such certificate or certificates shall be
deemed to have been issued, and the Holder or any other Person so designated to
be named therein shall be deemed to have become a Holder of record of such
shares for all purposes, as of the date when the notice, together with the
payment of the Warrant Price and this Warrant, is received by the Company as
described above. If this Warrant shall have been exercised in part, the Company
shall, at the time of delivery of the certificate or certificates representing
Warrant Stock, deliver to the Holder a new Warrant evidencing the rights of the
Holder to purchase the unpurchased shares of Common Stock called for by this
Warrant, which new Warrant shall in all other respects be identical with this
Warrant, or at the request of the Holder, appropriate notation may be made on
this Warrant

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and the same returned to the Holder.

         Payment of the Warrant Price may be made at the option of the Holder
by: (i) certified or official bank check payable to the order of the Company or
(ii) wire transfer of immediately available funds to the account of the Company.
All shares of Common Stock issuable upon the exercise of this Warrant pursuant
to the terms hereof shall be validly issued and, upon payment of the Warrant
Price, shall be fully paid and nonassessable and not subject to any preemptive
rights.

         2.2. Fractional Shares. The Company shall not be required to issue a
fractional share of Common Stock upon exercise of any Warrant. As to any
fraction of a share which the Holder of one or more Warrants, the rights under
which are exercised in the same transaction, would otherwise be entitled to
purchase upon such exercise, the Company shall pay an amount in cash equal to
the Current Market Price per share of Common Stock on the date of exercise
multiplied by such fraction.

         2.3. Restrictions on Exercise Amount.

         Unless a Holder delivers to the Company irrevocable written notice
prior to the date of issuance hereof or sixty-one days prior to the effective
date of such notice that this Section 2.3 shall not apply to such Holder, the
Holder may not acquire a number of shares of Warrant Stock to the extent that,
upon such exercise, the number of shares of Common Stock then beneficially owned
by such holder and its Affiliates and any other persons or entities whose
beneficial ownership of Common Stock would be aggregated with the Holder's for
purposes of Section 13(d) of the Exchange Act (including shares held by any
"group" of which the holder is a member, but excluding shares beneficially owned
by virtue of the ownership of securities or rights to acquire securities that
have limitations on the right to convert, exercise or purchase similar to the
limitation set forth herein) exceeds 4.99% of the total number of shares of
Common Stock of the Company then issued and outstanding. For purposes hereof,
"group" has the meaning set forth in Section 13(d) of the Exchange Act and
applicable regulations of the Commission, and the percentage held by the holder
shall be determined in a manner consistent with the provisions of Section 13(d)
of the Exchange Act. The Company shall have no obligation to verify compliance
with this Section 2.3, other than to issue shares of Warrant Stock in accordance
with the exercise notice of each Holder. It shall be the responsibility of each
Holder to determine such Holder's compliance with this Section 2.3, and each
delivery of a notice of exercise by a Holder will constitute a representation by
such Holder that it has evaluated the limitation set forth in this paragraph and
determined, based on the most recent public filings by the Company with the
Commission, that the issuance of the full number of shares of Warrant Stock
requested in such notice of exercise is permitted under this paragraph.

         3. Transfer, Division and Combination.

         3.1. Transfer. This Warrant and the Warrant Stock issuable upon
exercise of this Warrant shall be freely transferable, subject to compliance
with this Section 3.1 and all applicable laws, including, but not limited to the
Securities Act. If, at the time of the surrender of this Warrant in connection
with any transfer of this Warrant or the resale of the Warrant Stock, this
Warrant or the Warrant Stock, as applicable, shall not be registered under the

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Securities Act, the Company may require, as a condition of allowing such
transfer (i) that the Holder or transferee of this Warrant or the Warrant Stock
as the case may be, furnish to the Company a written opinion of counsel that is
reasonably acceptable to the Company to the effect that such transfer may be
made without registration under the Securities Act, (ii) that the Holder or
transferee execute and deliver to the Company an investment representation
letter in form and substance acceptable to the Company and substantially in the
form attached as Exhibit C hereto and (iii) that the transferee be an
"accredited investor" as defined in Rule 501(a) promulgated under the Securities
Act. Transfer of this Warrant and all rights hereunder, in whole or in part, in
accordance with the foregoing provisions, shall be registered on the books of
the Company to be maintained for such purpose, upon surrender of this Warrant at
the principal office of the Company referred to in Section 2.1 or the office or
agency designated by the Company pursuant to Section 10, together with a written
assignment of this Warrant substantially in the form of Exhibit B hereto duly
executed by the Holder or its agent or attorney and funds sufficient to pay any
transfer taxes payable upon the making of such transfer. Upon such surrender
and, if required, such payment, the Company shall execute and deliver a new
Warrant or Warrants in the name of the assignee or assignees and in the
denomination specified in such instrument of assignment, and shall issue to the
assignor a new Warrant evidencing the portion of this Warrant not so assigned,
and this Warrant shall promptly be cancelled. Following a transfer that complies
with the requirements of this Section 3.1, the Warrant may be exercised by a new
Holder for the purchase of shares of Common Stock regardless of whether the
Company issued or registered a new Warrant on the books of the Company.

         3.2. Restrictive Legends. Each certificate for Warrant Stock initially
issued upon the exercise of this Warrant, and each certificate for Warrant Stock
issued to any subsequent transferee of any such certificate, unless, in each
case, such Warrant Stock is eligible for resale without registration pursuant to
Rule 144(k) under the Exchange Act, or has been sold pursuant to and in
compliance with Rule 144 or an effective registration statement under the
Securities Act, shall bear the following legend:

"THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 AS AMENDED, AND MAY NOT BE OFFERED OR SOLD IN THE ABSENCE
OF AN EFFECTIVE REGISTRATION STATEMENT UNDER SAID ACT UNLESS, IN THE OPINION OF
COUNSEL REASONABLY SATISFACTORY TO THE COMPANY, SUCH REGISTRATION IS NOT
REQUIRED."

                  In addition, the legend set forth above shall be removed and
the Company shall issue a certificate without such legend to the holder of any
Warrant Stock upon which it is stamped, if, unless otherwise required by
applicable state securities laws, such Warrant Stock is eligible for resale
without registration pursuant to Rule 144(k) under the Exchange Act, or has been
sold pursuant to and in compliance with Rule 144 or an effective registration
statement filed under the Securities Act.

         3.3. Division and Combination; Expenses; Books. This Warrant may be
divided or combined with other Warrants upon presentation hereof at the
aforesaid office or agency of the Company, together with a written notice
specifying the names and denominations in which new Warrants are to be issued,
signed by the Holder or its agent or attorney. Subject to compliance with
Section 3.1 as to any transfer which may be involved in such division or
combination, the

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Company shall execute and deliver a new Warrant or Warrants in exchange for the
Warrant or Warrants to be divided or combined in accordance with such notice.
The Company shall prepare, issue and deliver at its own expense the new Warrant
or Warrants under this Section 3. The Company agrees to maintain, at its
aforesaid office or agency, books for the registration and the registration of
transfer of the Warrants.

         4. Adjustments. The number of shares of Common Stock for which this
Warrant is exercisable, and the price at which such shares may be purchased upon
exercise of this Warrant, shall be subject to adjustment from time to time as
set forth in this Section 4. The Company shall give the Holder notice of any
event described below which requires an adjustment pursuant to this Section 4 in
accordance with Sections 5.1 and 5.2.

         4.1. Stock Dividends, Subdivisions and Combinations. If at any time
while this Warrant is outstanding the Company shall:

                  (i) declare a dividend or make a distribution on its
outstanding shares of Common Stock payable in shares of Common Stock,

                  (ii) subdivide its outstanding shares of Common Stock into a
larger number of shares of Common Stock, or

                  (iii) combine its outstanding shares of Common Stock into a
smaller number of shares of Common Stock, then:

         (1) the number of shares of Common Stock acquirable upon exercise of
this Warrant immediately after the occurrence of any such event shall be
adjusted to equal the number of shares of Common Stock which a record holder of
the same number of shares of Common Stock that would have been acquirable under
this Warrant immediately prior to the record date for such dividend or
distribution or the effective date of such subdivision or combination would own
or be entitled to receive after such record date or the effective date of such
subdivision or combination, as applicable, and

         (2) the Current Warrant Price shall be adjusted to equal:

                  (A) the Current Warrant Price in effect at the time of the
         record date for such dividend or distribution or of the effective date
         of such subdivision or combination, multiplied by the number of shares
         of Common Stock into which this Warrant is exercisable immediately
         prior to the adjustment, divided by

                  (B) the number of shares of Common Stock into which this
         Warrant is exercisable immediately after such adjustment.

         Any adjustment made pursuant to clause (i) of this paragraph shall
become effective immediately after the record date for the determination of
stockholders entitled to receive such dividend or distribution, and any
adjustment pursuant to clauses (ii) or (iii) of this paragraph shall become
effective immediately after the effective date of such subdivision or
combination.

         4.2. Other Provisions Applicable to Adjustments. The following
provisions shall be

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applicable to the making of adjustments of the number of shares of Common Stock
into which this Warrant is exercisable and the Current Warrant Price provided
for in Section 4:

                  (a) When Adjustments to Be Made. The adjustments required by
Section 4 shall be made whenever and as often as any specified event requiring
an adjustment shall occur, except that any that would otherwise be required may
be postponed (except in the case of a subdivision or combination of shares of
the Common Stock, as provided for in Section 4.1) up to, but not beyond the date
of exercise if such adjustment either by itself or with other adjustments not
previously made adds or subtracts less than 1% of the shares of Common Stock
into which this Warrant is exercisable immediately prior to the making of such
adjustment. Any adjustment representing a change of less than such minimum
amount (except as aforesaid) which is postponed shall be carried forward and
made as soon as such adjustment, together with other adjustments required by
this Section 4 and not previously made, would result in a minimum adjustment or
on the date of exercise. For the purpose of any adjustment, any specified event
shall be deemed to have occurred at the close of business on the date of its
occurrence.

                  (b) Fractional Interests. In computing adjustments under this
Section 4, fractional interests in Common Stock shall be taken into account to
the nearest 1/100th of a share.

                  (c) When Adjustment Not Required. If the Company undertakes a
transaction contemplated under this Section 4 and as a result takes a record of
the holders of its Common Stock for the purpose of entitling them to receive a
dividend or distribution or subscription or purchase rights or other benefits
contemplated under this Section 4 and shall, thereafter and before the
distribution to stockholders thereof, legally abandon its plan to pay or deliver
such dividend, distribution, subscription or purchase rights or other benefits
contemplated under this Section 4, then thereafter no adjustment shall be
required by reason of the taking of such record and any such adjustment
previously made in respect thereof shall be rescinded and annulled.

                  (d) Escrow of Stock. If after any property becomes
distributable pursuant to Section 4 by reason of the taking of any record of the
holders of Common Stock, but prior to the occurrence of the event for which such
record is taken, a holder of this Warrant exercises the Warrant during such
time, then such holder shall continue to be entitled to receive any shares of
Common Stock issuable upon exercise hereunder by reason of such adjustment and
such shares or other property shall be held in escrow for the holder of this
Warrant by the Company to be issued to holder of this Warrant upon and to the
extent that the event actually takes place. Notwithstanding any other provision
to the contrary herein, if the event for which such record was taken fails to
occur or is rescinded, then such escrowed shares shall be canceled by the
Company and escrowed property returned to the Company.

         4.3. Reorganization, Reclassification, Merger, Consolidation or
Disposition of Assets.

                  (a) If there shall occur a Change of Control during the period
beginning on the date hereof and ending on the Expiration Date, and, pursuant to
the terms of such Change of Control, shares of common stock of the successor or
acquiring corporation, or any cash, shares of stock or other securities or
property of any nature whatsoever (including warrants or other subscription or
purchase rights) in addition to or in lieu of common stock of the successor or
acquiring corporation ("Other Property"), are to be received by or distributed
to the holders of

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Common Stock of the Company, then the Holder of this Warrant shall have the
right thereafter to receive, upon the exercise of the Warrant, the number of
shares of common stock of the successor or acquiring corporation or of the
Company, if it is the surviving corporation, and the Other Property receivable
upon or as a result of such Change of Control by a holder of the number of
shares of Common Stock into which this Warrant is exercisable immediately prior
to such event.

                  (b) In case of any such Change of Control described in Section
4.3(a) above, the resulting, successor or acquiring entity (if not the Company)
and, if an entity different from the successor or acquiring entity, the entity
whose capital stock or assets the holders of the Common Stock are entitled to
receive as a result of such Change of Control, shall assume by written
instrument all of the obligations of this Warrant, subject to such modifications
as may be deemed appropriate (as determined by resolution of the Board of
Directors of the Company) in order to provide for adjustments of shares of the
Common Stock into which this Warrant is exercisable which shall be as nearly
equivalent as practicable to the adjustments provided for in Section 4. For
purposes of Section 4, common stock of the successor or acquiring corporation
shall include stock of such corporation of any class which is not preferred as
to dividends or assets on liquidation over any other class of stock of such
corporation and which is not subject to redemption and shall also include any
evidences of indebtedness, shares of stock or other securities which are
convertible into or exchangeable for any such stock, either immediately or upon
the arrival of a specified date or the happening of a specified event and any
warrants or other rights to subscribe for or purchase any such stock. The
foregoing provisions of this Section 4 shall similarly apply to successive
Change of Control transactions.

         4.4. Other Action Affecting Common Stock. In case at any time or from
time to time the Company shall take any action in respect of its Common Stock,
other than the payment of cash dividends payable out of earnings or earned
surplus legally available for the payment of dividends under the laws of the
jurisdiction of incorporation of the Company or any action described in Section
4, then, unless such action will not have a materially adverse effect upon the
rights of the holder of this Warrant, the number of shares of Common Stock or
other stock into which this Warrant is exercisable and/or the purchase price
thereof shall be adjusted in such manner as may be equitable in the
circumstances.

         4.5. Certain Limitations. Notwithstanding anything herein to the
contrary, the Company agrees not to enter into any transaction which, by reason
of any adjustment hereunder, would cause the Current Warrant Price to be less
than the par value per share of Common Stock.

         4.6. Stock Transfer Taxes. The issue of stock certificates upon
exercise of this Warrant shall be made without charge to the holder for any tax
in respect of such issue. The Company shall not, however, be required to pay any
tax which may be payable in respect of any transfer involved in the issue and
delivery of shares in any name other than that of the holder of this Warrant,
and the Company shall not be required to issue or deliver any such stock
certificate unless and until the person or persons requesting the issue thereof
shall have paid to the Company the amount of such tax or shall have established
to the satisfaction of the Company that such tax has been paid.

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         5.       Notices to Warrant Holders.

         5.1. Certificate as to Adjustments. Upon the occurrence of each
adjustment or readjustment of the Current Warrant Price, the Company, at its
expense, shall promptly compute such adjustment or readjustment in accordance
with the terms hereof and prepare and furnish to the Holder of this Warrant a
certificate setting forth such adjustment or readjustment and showing in detail
the facts upon which such adjustment or readjustment is based. The Company
shall, upon the written request at any time of the Holder of this Warrant,
furnish or cause to be furnished to such Holder a like certificate setting forth
(i) such adjustments and readjustments, (ii) the Current Warrant Price at the
time in effect and (iii) the number of shares of Common Stock and the amount, if
any, or other property which at the time would be received upon the exercise of
Warrants owned by such Holder.

         5.2. Notice of Corporate Action. If at any time:

                  (a) the Company shall take a record of the holders of its
Common Stock for the purpose of entitling them to receive a dividend or other
distribution, or any right to subscribe for or purchase any evidences of its
indebtedness, any shares of stock of any class or any other securities or
property, or to receive any other right, or

                  (b) there shall be any capital reorganization of the Company,
any reclassification or recapitalization of the capital stock of the Company or
any consolidation or merger of the Company with, or any sale, transfer or other
disposition of all or substantially all the property, assets or business of the
Company to, another corporation, or

                  (c) there shall be a voluntary or involuntary dissolution,
liquidation or winding up of the Company; or

                  (d) the Company shall cause the holders of its Common Stock to
be entitled to receive (i) any dividend or other distribution of cash, (ii) any
evidences of its indebtedness, or (iii) any shares of stock of any class or any
other securities or property or assets of any nature whatsoever (other than cash
or additional shares of Common Stock as provided in Section 4.1 hereof); or (iv)
any warrants or other rights to subscribe for or purchase any evidences of its
indebtedness, any shares of stock of any class or any other securities or
property or assets of any nature whatsoever;

then, in any one or more of such cases, the Company shall give to the Holder (i)
at least 15 days' prior written notice of the record date selected for such
dividend, distribution or right or for determining rights to vote in respect of
any such reorganization, reclassification, merger, consolidation, sale,
transfer, disposition, dissolution, liquidation or winding up, and (ii) in the
case of any such reorganization, reclassification, merger, consolidation, sale,
transfer, disposition, dissolution, liquidation or winding up, at least 15 days'
prior written notice of the date when the same shall take place. Such notice in
accordance with the foregoing clause also shall specify (i) the date on which
any such record is to be taken for the purpose of such dividend, distribution or
right, the date on which the holders of Common Stock shall be entitled to any
such dividend, distribution or right, and the amount and character thereof, and
(ii) the date on which any such reorganization, reclassification, merger,
consolidation, sale, transfer, disposition, dissolution, liquidation or winding
up is to take place and the time, if any such time is to be fixed, as of which
the holders of Common Stock shall be entitled to exchange their

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shares of Common Stock for securities or other property deliverable upon such
reorganization, reclassification, merger, consolidation, sale, transfer,
disposition, dissolution, liquidation or winding up. Each such written notice
shall be sufficiently given if addressed to the Holder at the last address of
the Holder appearing on the books of the Company and delivered in accordance
with Section 12.2. The failure to give any notice required by this Section 5.2
shall not invalidate any such corporate action.

         5.3. No Rights as Stockholder. This Warrant does not entitle the Holder
to any voting or other rights as a stockholder of the Company prior to exercise
and payment for the Warrant Price in accordance with the terms hereof.

         6. No Impairment. The Company shall not by any action, including,
without limitation, amending its certificate of incorporation or through any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities or any other voluntary action, avoid or seek to avoid the
observance or performance of any of the terms of this Warrant, but will at all
times in good faith assist in the carrying out of all such terms and in the
taking of all such actions as may be necessary or appropriate to protect the
rights of the Holder against impairment. Without limiting the generality of the
foregoing, the Company will (a) not increase the par value of any shares of
Common Stock receivable upon the exercise of this Warrant above the amount
payable therefor upon such exercise immediately prior to such increase in par
value, (b) take all such action as may be necessary or appropriate in order that
the Company may validly and legally issue fully paid and nonassessable shares of
Common Stock upon the exercise of this Warrant, and (c) use its best efforts to
obtain all such authorizations, exemptions or consents from any public
regulatory body having jurisdiction thereof as may be necessary to enable the
Company to perform its obligations under this Warrant. Upon the request of the
Holder, the Company will at any time during the period this Warrant is
outstanding acknowledge in writing, in form satisfactory to the Holder, the
continuing validity of this Warrant and the obligations of the Company
hereunder.

         7. Reservation and Authorization of Common Stock; Registration With
Approval of Any Governmental Authority. From and after the Closing Date, the
Company shall at all times reserve and keep available for issue upon the
exercise of Warrants such number of its authorized but unissued shares of Common
Stock as will be sufficient to permit the exercise in full of all outstanding
Warrants (without regard to any ownership limitations provided in Section 2.3).
All shares of Common Stock which shall be so issuable, when issued upon exercise
of any Warrant and payment therefor in accordance with the terms of such
Warrant, shall be duly and validly issued and fully paid and nonassessable, and
not subject to preemptive rights. Before taking any action which would cause an
adjustment reducing the Current Warrant Price below the then par value, if any,
of the shares of Common Stock issuable upon exercise of the Warrants, the
Company shall take any corporate action which may be necessary in order that the
Company may validly and legally issue fully paid and non-assessable shares of
such Common Stock at such adjusted Current Warrant Price. Before taking any
action which would result in an adjustment in the number of shares of Common
Stock for which this Warrant is exercisable or in the Current Warrant Price, the
Company shall obtain all such authorizations or exemptions thereof, or consents
thereto, as may be necessary from any public regulatory body or bodies having
jurisdiction thereof. If any shares of Common Stock required to be reserved for
issuance upon exercise of Warrants require registration or qualification with
any governmental authority

                                       11
<PAGE>
under any federal or state law before such shares may be so issued (other than
as a result of a prior or contemplated distribution by the Holder of this
Warrant), the Company will in good faith and as expeditiously as possible and at
its expense endeavor to cause such shares to be duly registered.

         8. Taking of Record; Stock and Warrant Transfer Books. In the case of
all dividends or other distributions by the Company to the holders of its Common
Stock with respect to which any provision of Section 4 refers to the taking of a
record of such holders, the Company will in each such case take such a record
and will take such record as of the close of business on a Business Day. The
Company will not at any time, except upon dissolution, liquidation or winding up
of the Company, close its stock transfer books or Warrant transfer books so as
to result in preventing or delaying the exercise or transfer of any Warrant.

         9. Loss or Mutilation. Upon receipt by the Company from the Holder of
evidence reasonably satisfactory to it of the ownership of and the loss, theft,
destruction or mutilation of this Warrant and indemnity or security reasonably
satisfactory to it and reimbursement to the Company of all reasonable expenses
incidental thereto and in case of mutilation upon surrender and cancellation
hereof, the Company will execute and deliver in lieu hereof a new Warrant of
like tenor to the Holder; provided, however, that in the case of mutilation, no
indemnity shall be required if this Warrant in identifiable form is surrendered
to the Company for cancellation.

         10. Office of the Company. As long as any of the Warrants remain
outstanding, the Company shall maintain an office or agency (which may be the
principal executive offices of the Company) where the Warrants may be presented
for exercise, registration of transfer, division or combination as provided in
this Warrant.

         11. Limitation of Liability. No provision hereof, in the absence of
affirmative action by the Holder to purchase shares of Common Stock, and no
enumeration herein of the rights or privileges of the Holder hereof, shall give
rise to any liability of the Holder for the purchase price of any Common Stock,
whether such liability is asserted by the Company or by creditors of the
Company.

         12.      Miscellaneous.

         12.1. Nonwaiver and Expenses. No course of dealing or any delay or
failure to exercise any right hereunder on the part of the Holder shall operate
as a waiver of such right or otherwise prejudice the Holder's rights, powers or
remedies. If the Company fails to make, when due, any payments provided for
hereunder, or fails to comply with any other material provision of this Warrant,
the Company shall pay to the Holder such amounts as shall be sufficient to cover
any third party costs and expenses including, but not limited to, reasonable
attorneys' fees, including those of appellate proceedings, incurred by the
Holder in collecting any amounts due pursuant hereto or in otherwise enforcing
any of its rights, powers or remedies hereunder.

         12.2. Notice Generally. Any and all notices or other communications or
deliveries required or permitted to be provided hereunder shall be in writing
and shall be deemed given and effective on the earliest of (a) the date of
transmission, if such notice or communication is delivered via facsimile at the
facsimile number specified on the signature pages attached hereto

                                       12
<PAGE>
prior to 5:00 p.m. (New York City time) on a Trading Day, (b) the next Trading
Day after the date of transmission, if such notice or communication is delivered
via facsimile at the facsimile number included with the address for the
recipient as provided herein on a day that is not a Trading Day or later than
5:00 p.m. (New York City time) on any Trading Day, (c) the Trading Day following
the date of mailing, if sent by U.S. nationally recognized overnight courier
service, or (d) upon actual receipt by the party to whom such notice is required
to be given. The address for such notices and communications shall be as
follows:

         If to the Purchasers, at each Purchaser's address set forth in the
books and records of the Company, or with respect to the Company, addressed to:

              Spectrum Pharmaceuticals, Inc.
              157 Technology Drive
              Irvine, California 92618
              Attention: CEO
              Facsimile No.: (949) 788-6706

or to such other address or addresses or facsimile number or numbers as any such
party may most recently have designated in writing to the other parties hereto
by such notice. Copies of notices to the Company shall be sent to:

              Latham & Watkins LLP
              650 Town Center Drive, Suite 2000
              Costa Mesa, California 92626
              Attention:  Alan W. Pettis
              Facsimile No.: (714) 755-8290

         12.3. Successors and Assigns. Subject to compliance with the provisions
of Section 3.1, this Warrant and the rights evidenced hereby shall inure to the
benefit of and be binding upon the successors of the Company and the successors
and assigns of the Holder. The provisions of this Warrant are intended to be for
the benefit of all Holders from time to time of this Warrant, and shall be
enforceable by any such Holder.

         12.4. Amendment. This Warrant may be modified or amended or the
provisions of this Warrant waived with the written consent of both the Company
and the Holder.

         12.5. Severability. Wherever possible, each provision of this Warrant
shall be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Warrant shall be prohibited by or
invalid under applicable law, such provision shall be modified to the extent of
such prohibition or invalidity, without invalidating the remainder of such
provision or the remaining provisions of this Warrant.

         12.6. Headings. The headings used in this Warrant are for the
convenience of reference only and shall not, for any purpose, be deemed a part
of this Warrant.

         12.7. Governing Law. This Warrant and the transactions contemplated
hereby shall be deemed to be consummated in the State of New York and shall be
governed by and interpreted in

                                       13
<PAGE>
accordance with the local laws of the State of New York without regard to the
provisions thereof relating to conflicts of laws. The Company hereby irrevocably
consents to the exclusive jurisdiction of the State and Federal courts located
in New York City, New York in connection with any action or proceeding arising
out of or relating to this Warrant. In any such litigation the Company agrees
that the service thereof may be made by certified or registered mail directed to
the Company pursuant to Section 12.2.

                            [Signature Page Follows]

                                       14
<PAGE>

         IN WITNESS WHEREOF, Spectrum Pharmaceuticals, Inc. has caused this
Warrant to be executed by its duly authorized officer and attested by its
Secretary.

Dated: April 21, 2004

                                             SPECTRUM PHARMACEUTICALS, INC.

                                             By:    /s/ Rajesh C. Shrotriya
                                                    -----------------------
                                             Name:  Rajesh C. Shrotriya, M.D.
                                             Title: Chairman, CEO and President

Attest:

By:    /s/ Shyam Kumaria
       --------------------
Name:  Shyam Kumaria
Title: Secretary

 See Schedule 1 to the Common Stock and Warrant Purchase Agreement dated as of
            April 20, 2004 (filed as Exhibit 10.1 to this Form 8-K)
               for name of each purchaser receiving warrants and
                the number of warrants issued to each Purchaser.

                                       15
<PAGE>
                                    EXHIBIT A

                                SUBSCRIPTION FORM

                 [To be executed only upon exercise of Warrant]

         1. The undersigned registered owner of this Warrant hereby elects to
exercise this Warrant to purchase shares of the Common Stock of Spectrum
Pharmaceuticals, Inc. pursuant to the terms of the attached Warrant, and tenders
herewith payment of the purchase price of such shares in full.

         2. By signing below, the undersigned hereby certifies that the exercise
of the Warrant for the number of shares of Common Stock indicated above will not
violate the limitation on the number of shares that may be acquired upon
exercise of the Warrant set forth in Section 2.3 of the Warrant.

         3. Please issue a certificate or certificates representing said shares
of Common Stock in the name of the undersigned or in such other name as is
specified below:

                                                  ------------------------------
                                                            (Name)

                                                  ------------------------------

                                                  ------------------------------

                                                  ------------------------------
                                                          (Address)

         [and, if such shares of Common Stock shall not include all of the
shares of Common Stock issuable as provided in this Warrant, that a new Warrant
of like tenor and date for the balance of the shares of Common Stock issuable
hereunder be delivered to the undersigned.]

-------------------------------------
(Name of Registered Owner)

-------------------------------------
(Signature of Registered Owner)

-------------------------------------
(Street Address)

-------------------------------------
(State) (Zip Code)

NOTICE: The signature on this subscription must correspond with the name as
written upon the face of the Warrant in every particular, without alteration or
enlargement or any change whatsoever.

                                       16
<PAGE>
                                    EXHIBIT B

                                 ASSIGNMENT FORM

FOR VALUE RECEIVED the undersigned registered owner of this Warrant for the
purchase of shares of common stock of Spectrum Pharmaceuticals, Inc. hereby
sells, assigns and transfers unto the Assignee named below all of the rights of
the undersigned under this Warrant, with respect to the number of shares of
common stock set forth below:

---------------------------------------

---------------------------------------

---------------------------------------
(Name and Address of Assignee)

---------------------------------------
(Number of Shares of Common Stock)

and does hereby irrevocably constitute and appoint ____________ attorney-in-fact
to register such transfer on the books of the Company, maintained for the
purpose, with full power of substitution in the premises.

Dated:_________________________________

--------------------------------------
(Print Name and Title)

--------------------------------------
(Signature)

--------------------------------------
(Witness)

NOTICE: The signature on this assignment must correspond with the name as
written upon the face of the Warrant in every particular, without alteration or
enlargement or any change whatsoever.

                                       17
<PAGE>
                                    EXHIBIT C

                    FORM OF INVESTMENT REPRESENTATION LETTER

In connection with the acquisition of [warrants (the "Warrants") to purchase
____ shares of common stock of Spectrum Pharmaceuticals, Inc. (the "Company"),
par value $0.001 per share (the "Common Stock")][___shares of common stock of
Spectrum Pharmaceuticals, Inc. (the "Company"), par value $0.001 per share (the
"Common Stock") upon the exercise of warrants by ________], by _______________
(the "Holder") from _____________, the Holder hereby represents and warrants to
the Company as follows:

The Holder (i) is an "Accredited Investor" as that term is defined in Rule 501
of Regulation D promulgated under the Securities Act of 1933, as amended (the
"Act"); (ii) has the ability to bear the economic risks of such Holder's
prospective investment, including a complete loss of Holder's investment in the
Warrants and the shares of Common Stock issuable upon the exercise thereof
(collectively, the "Securities"); and (iii) is acquiring the securities such
Holder's own account for investment and not with a view to, or for sale in
connection with, any distribution thereof, nor with the intention of
distributing or reselling the same, provided, however, that by making the
representation herein, the Holder does not agree to hold any of the Securities
for any minimum or other specific term and reserves the right to dispose of the
Securities at any time in accordance with or pursuant to a registration
statement or an exemption from registration under the Securities Act..

 [The Holder acknowledges that (i) the Securities have not been registered under
the Act, (ii) the Securities are "restricted securities" and the certificate(s)
representing the Securities shall bear the following legend, or a similar legend
to the same effect, until (i) in the case of the shares of Common Stock
underlying the Warrants, such shares shall have been registered for resale by
the Holder under the Act and effectively been disposed of in accordance with a
registration statement that has been declared effective; (ii) such Securities
have been sold pursuant to and in accordance with Rule 144 under the Act; or
(iii) such Securities may be sold pursuant to and in accordance with Rule 144(k)
under the Act:

"THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 AS AMENDED, AND MAY NOT BE OFFERED OR SOLD IN THE ABSENCE
OF AN EFFECTIVE REGISTRATION STATEMENT UNDER SAID ACT UNLESS, IN THE OPINION OF
COUNSEL REASONABLY SATISFACTORY TO THE COMPANY, SUCH REGISTRATION IS NOT
REQUIRED."

                                       18
<PAGE>
IN WITNESS WHEREOF, the Holder has caused this Investment Representation Letter
to be executed this __ day of __________ 200_.

[Name]

By:______________________________
Name:
Title:

                                       19<PAGE>

                                                                    EXHIBIT 10.1

  -----------------------------------------------------------------------------

                   COMMON STOCK AND WARRANT PURCHASE AGREEMENT

                                  by and among

                         Spectrum Pharmaceuticals, Inc.

                                       and

              the parties named herein on Schedule 1, as Purchasers

                                 April 20, 2004

  -----------------------------------------------------------------------------
<PAGE>
      This COMMON STOCK AND WARRANT PURCHASE AGREEMENT (this "Agreement") is
dated as of April 20, 2004, among Spectrum Pharmaceuticals, Inc., a Delaware
corporation (the "Company"), and the purchasers identified on Schedule 1 hereto
(each a "Purchaser" and collectively the "Purchasers").

      WHEREAS, subject to the terms and conditions set forth in this Agreement,
the Company desires to issue and sell to the Purchasers, and the Purchasers,
severally and not jointly, desire to purchase from the Company in the aggregate,
3,220,005 shares of Common Stock and Warrants to purchase 1,127,005 shares of
Common Stock.

      NOW, THEREFORE, in consideration of the mutual covenants contained in this
Agreement, and for other good and valuable consideration the receipt and
adequacy of which are hereby acknowledged, the Company and each Purchaser agree
as follows:

                                    ARTICLE I

                                   DEFINITIONS

      1.1 DEFINITIONS.

      In addition to the terms defined elsewhere in this Agreement, for all
purposes of this Agreement, the following terms have the meanings indicated in
this Section 1.1:

      "Affiliate" means any Person that, directly or indirectly through one or
more intermediaries, controls or is controlled by or is under common control
with a Person, as such terms are used in and construed under Rule 144. With
respect to a Purchaser, any investment fund or managed account that is managed
on a discretionary basis by the same investment manager as such Purchaser will
be deemed to be an Affiliate of such Purchaser.

      "Agreement" shall have the meaning ascribed to such term in the Preamble.

      "Business Day" means any day except Saturday, Sunday and any day which
shall be a federal legal holiday or a day on which banking institutions in the
State of California are authorized or required by law or other governmental
action to close.

      "Closing" shall have the meaning ascribed to such term in Section 2.1(a).

      "Closing Date" shall have the meaning ascribed to such term in Section
2.1(a).

      "Commission" means the Securities and Exchange Commission.

      "Common Stock" means the common stock of the Company, $0.001 par value per
share, and any securities into which such common stock may hereafter be
reclassified.

      "Common Stock Equivalents" means any securities of the Company or the
Subsidiaries which would entitle the holder thereof to acquire at any time
shares of Common Stock, including without limitation, any debt, preferred stock,
rights, options, warrants or other instrument that is
<PAGE>
at any time convertible into or exchangeable for, or otherwise entitles the
holder thereof to receive, Common Stock.

      "Company" shall have the meaning ascribed to such term in the Preamble.

      "Disclosure Schedules" means the Disclosure Schedules concurrently
delivered herewith.

      "Effective Date" means the date that the Registration Statement is first
declared effective by the Commission.

      "Environmental Laws" shall have the meaning ascribed to such term in
Section 3.25.

      "Exchange Act" means the Securities Exchange Act of 1934, as amended.

      "FDC Act" shall have the meaning ascribed to such term in Section 3.26.

      "GAAP" shall have the meaning ascribed to such term in Section 3.7.

      "Governmental Authorizations" shall have the meaning ascribed to such term
in Section 3.26(a).

      "Hazardous Substances" shall have the meaning ascribed to such term in
Section 3.25.

      "Indemnified Party" shall have the meaning ascribed to such term in
Section 6.3.

      "Indemnifying Party" shall have the meaning ascribed to such term in
Section 6.3.

      "Intellectual Property" shall have the meaning ascribed to such term in
Section 3.15.

      "Investor Rights Agreement" means the Investor Rights Agreement, dated as
of the date of this Agreement, between the Company and each of the Purchasers,
in the form of Exhibit A hereto.

      "Lien" means a lien, charge, security interest, encumbrance, right of
first refusal or other restriction, except for a lien for current taxes not yet
due and payable and a minor imperfection of title, if any, not material in
nature or amount and not materially detracting from the value or impairing the
use of the property subject thereto or impairing the operations or proposed
operations of the Company.

      "Material Adverse Effect" shall have the meaning ascribed to such term in
Section 3.1.

      "Per Share Purchase Price" equals $7.75.

      "Person" means an individual or corporation, partnership, trust,
incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof)
or other entity of any kind.

      "Premises" shall have the meaning ascribed to such term in Section 3.25.

                                       3
<PAGE>
      "Purchaser" shall have the meaning ascribed to such term in the Preamble.

      "Registration Statement" means a registration statement meeting the
requirements set forth in the Investor Rights Agreement and covering the resale
by the Purchasers of the Shares and the Warrant Shares.

      "Rights" shall have the meaning ascribed to such term in Section 3.15.

      "Rule 144" means Rule 144 promulgated by the Commission pursuant to the
Securities Act, as such Rule may be amended from time to time, or any similar
rule or regulation hereafter adopted by the Commission having substantially the
same effect as such Rule.

      "SEC Documents" shall have the meaning ascribed to such term in Section
3.6.

      "Securities" means the Shares, the Warrants and the Warrant Shares.

      "Securities Act" means the Securities Act of 1933, as amended.

      "Shares" means the shares of Common Stock issued to each Purchaser
pursuant to this Agreement.

      "Subscription Amount" means, as to each Purchaser, the amount set forth
beside such Purchaser's name on Schedule 1 hereto, in United States dollars and
in immediately available funds.

      "Subsidiary" means, with respect to any entity, any corporation or other
organization of which securities or other ownership interest having ordinary
voting power to elect a majority of the board of directors or other persons
performing similar functions, are directly or indirectly owned by such entity or
of which such entity is a partner or is, directly or indirectly, the beneficial
owner of 50% or more of any class of equity securities or equivalent profit
participation interests.

      "Trading Day" means (i) a day on which the Common Stock is traded on a
Trading Market, or (ii) if the Common Stock is not listed on a Trading Market, a
day on which the Common Stock is traded on the over-the-counter market, as
reported by the OTC Bulletin Board, or (iii) if the Common Stock is not quoted
on the OTC Bulletin Board, a day on which the Common Stock is quoted in the
over-the-counter market as reported by the National Quotation Bureau
Incorporated (or any similar organization or agency succeeding to its functions
of reporting prices); provided, that in the event that the Common Stock is not
listed or quoted as set forth in (i), (ii) and (iii) hereof, then Trading Day
shall mean a Business Day.

      "Trading Market" means the following markets or exchanges on which the
Common Stock is listed or quoted for trading on the date in question: the
American Stock Exchange, the New York Stock Exchange, the NASDAQ National Market
or the NASDAQ SmallCap Market.

      "Transaction Documents" means this Agreement, the Investor Rights
Agreement, the Warrants and any other documents or agreements executed in
connection with the transactions contemplated hereunder.

                                       4
<PAGE>
      "Warrants" means the Common Stock Purchase Warrants, in the form of
Exhibit B hereto. SG Cowen Securities Corporation (the "Placement Agent") and/or
its designees are also receiving placement agent warrants as compensation for
services rendered in connection with the transaction set forth herein as
provided on Schedule 1 attached hereto, which warrants shall be in the form of
Exhibit C hereto. Such placement agent warrants shall also constitute "Warrants"
for all purposes hereunder and the Placement Agent and/or its designees and such
other persons or entities shall constitute "Purchasers" for all purposes
hereunder.

      "Warrant Shares" means the shares of Common Stock issuable upon exercise
of the Warrants.

                                   ARTICLE II

                                PURCHASE AND SALE

      2.1 CLOSING.

      (a) The closing of the transactions contemplated under this Agreement (the
"Closing") will take place as promptly as practicable, but no later than two (2)
Business Days following satisfaction or waiver of the conditions set forth in
Sections 2.2 and 2.3 (other than those conditions which by their terms are not
to be satisfied or waived until the Closing), at the offices of Wiggin and Dana
LLP, 400 Atlantic Street, Stamford, CT 06901 (or remotely via exchange of
documents and signatures) or at such other place or day as may be mutually
acceptable to the Purchasers and the Company. The date on which the Closing
occurs is the "Closing Date".

      (b) At the Closing, the Purchasers shall purchase, severally and not
jointly, and the Company shall issue and sell, in the aggregate, 3,220,005
shares of Common Stock and Warrants to purchase 1,127,005 shares of Common Stock
on the Closing Date. Each Purchaser shall purchase from the Company, and the
Company shall issue and sell to each Purchaser, a number of Shares equal to such
Purchaser's Subscription Amount divided by the Per Share Purchase Price and a
Warrant to purchase 35% of the number of Shares purchased by such Purchaser.

      2.2 CONDITIONS TO OBLIGATIONS OF PURCHASERS TO EFFECT THE CLOSING.

      The obligations of each Purchaser to effect the Closing and the
transactions contemplated by this Agreement shall be subject to the satisfaction
at or prior to the Closing of each of the following conditions, any of which may
be waived, in writing, by such Purchaser:

      (a) At the Closing (unless otherwise specified below) the Company shall
deliver or cause to be delivered to each Purchaser the following:

            (i) this Agreement, duly executed by the Company;

            (ii) a certificate evidencing a number of Shares equal to such
Purchaser's Subscription Amount divided by the Per Share Purchase Price as set
forth on Schedule 1 hereto, registered in the name of such Purchaser;

                                       5
<PAGE>
            (iii) a Warrant, registered in the name of such Purchaser, pursuant
to which such Purchaser shall have the right to acquire up to the number of
shares of Common Stock equal to 35% of the Shares to be issued to such Purchaser
at such Closing, as set forth on Schedule 1 hereto;

            (iv) the Investor Rights Agreement, duly executed by the Company;

            (v) a legal opinion of Latham & Watkins LLP, counsel to the Company,
in the form of Exhibit E hereto; and

            (vi) a certificate of the Secretary of the Company (the "Secretary's
Certificate"), attaching a true copy of the Certificate of Incorporation and
Bylaws of the Company, as amended to the Closing Date, and attaching true and
complete copies of the resolutions of the Board of Directors of the Company
authorizing the execution, delivery and performance of this Agreement and the
other Transaction Documents.

      (b) All representations and warranties of the Company contained herein
shall remain true and correct as of the Closing Date as though such
representations and warranties were made on such date (except those
representations and warranties that address matters only as of a particular date
will remain true and correct as of such date).

      (c) As of the Closing Date, there shall have been no Material Adverse
Effect with respect to the Company since the date hereof.

      2.3. CONDITIONS TO OBLIGATIONS OF THE COMPANY TO EFFECT THE CLOSING.

      (a) The obligations of the Company to effect the Closing and the
transactions contemplated by this Agreement shall be subject to the satisfaction
at or prior to the Closing of each of the following conditions, any of which may
be waived, in writing, by the Company. At the Closing, each Purchaser shall
deliver or cause to be delivered to the Company the following:

            (i) this Agreement, duly executed by such Purchaser;

            (ii) such Purchaser's Subscription Amount, by wire transfer of
immediately available funds to the Company at the following account:

            Bank: UBS AG, Stamford, Connecticut
            ABA Number: 026007993
            Account Number: 101-WA258640-000
            For credit to: MA 48352 Spectrum Pharmaceuticals, Inc.
            ; and

            (iii) the Investor Rights Agreement, duly executed by such
Purchaser.

      (b) All representations and warranties of each of the Purchasers contained
herein shall remain true and correct as of the Closing Date as though such
representations and warranties were made on such date.

                                       6
<PAGE>
                                   ARTICLE III

                    REPRESENTATIONS AND WARRANTIES OF COMPANY

      For purposes of this Article III, all references to the Company and its
Subsidiaries shall be deemed to include all their respective predecessor
entities, if any. The Company represents, warrants and covenants to the
Purchasers, except as set forth on the Company's Disclosure Schedule attached
hereto as Schedule 3 specifically identifying the applicable section of this
Article III, it being understood that information disclosed under a particular
section of Schedule 3 shall be deemed disclosed only for purposes of such
section and not for purposes of or with respect to any other section of this
Article III, as of the date hereof, as follows:

      3.1 CORPORATE EXISTENCE AND POWER; SUBSIDIARIES. The Company and its
Subsidiaries are corporations duly incorporated, validly existing and in good
standing under the laws of the state in which they are incorporated, and have
all corporate powers required to carry on their business as now conducted. The
Company and its Subsidiaries are duly qualified to do business as a foreign
corporation and are in good standing in each jurisdiction where the character of
the property owned or leased by them or the nature of their activities makes
such qualification necessary, except for those jurisdictions where the failure
to be so qualified would not have a Material Adverse Effect on the Company or
any of its Subsidiaries. For purposes of this Agreement, the term "Material
Adverse Effect" means, with respect to any person or entity, a material adverse
effect on its or its Subsidiaries' condition (financial or otherwise), business,
properties, assets, liabilities (including contingent liabilities), and results
of operations. True and complete copies of the Company's Certificate of
Incorporation, as amended, and Bylaws, as amended (the "Charter" and "Bylaws"
respectively, or collectively, the "Charter and Bylaws") have previously been
provided to the Purchasers. The Company has no Subsidiaries other than as set
forth in Exhibit 21 to the Company's annual report on Form 10-K for the fiscal
year ended December 31, 2003.

      3.2 CORPORATE AUTHORIZATION; RIGHTS PLAN. (a) The execution, delivery and
performance by the Company of this Agreement and the other Transaction
Documents, and the consummation of the transactions contemplated hereby and
thereby (including, but not limited to, the sale and delivery of the Shares and
the Warrants, and the subsequent issuance of the Warrant Shares upon exercise of
the Warrants, have been duly authorized, and no additional corporate action is
required for the approval of this Agreement or the Transaction Documents. The
Shares and the Warrant Shares have been duly reserved for issuance by the
Company. This Agreement and the Transaction Documents have been or, to the
extent contemplated hereby or by the Transaction Documents, will be duly
executed and delivered and constitute the legal, valid and binding agreement of
the Company, enforceable against the Company in accordance with their terms,
except as may be limited by bankruptcy, reorganization, insolvency, moratorium
and similar laws of general application relating to or affecting the enforcement
of rights of creditors, and except as enforceability of its obligations
hereunder are subject to general principles of equity.

            (b) The Shares that will be issued to the Purchasers at Closing will
have been duly and validly reserved for issuance and, when issued and delivered
in accordance with the terms hereof, will be duly authorized, validly issued,
fully paid and non-assessable and free

                                       7
<PAGE>
of restrictions on transfer other than applicable state and federal securities
laws. The Common Stock issuable upon exercise of the Warrants has been duly and
validly reserved for issuance, and upon issuance in accordance with the terms of
the Warrants, will be duly authorized, validly issued, fully paid and
non-assessable and free of restrictions on transfer other than applicable
federal and state securities laws and, assuming the accuracy of the
representations and warranties of the Purchasers, will be issued in compliance
with all applicable federal and state securities laws.

            (c) The issuance of the Shares, the Warrants, or the Common Stock
upon exercise of the Warrants, as applicable, will not result in or obligate the
Company to (i) issue or offer to issue, with or without consideration, any
securities or rights to acquire any securities to any person, whether as a
pre-emptive right, or pursuant to any rights plan, or pursuant to any agreement,
undertaking or other obligation of any nature, or (ii) adjust the number or kind
of securities held by or issuable (with or without the payment of any
consideration) to any person.

      3.3 CORPORATE RECORDS. The minute books of the Company and its
Subsidiaries contain complete and accurate records of all meetings and other
corporate actions of the board of directors, committees of the board of
directors, incorporators and shareholders of the Company and its Subsidiaries
from the date of their incorporation to the date hereof. All material corporate
decisions and actions have been validly made or taken. The Company's share
transfer register complies with applicable laws and regulations and has been
regularly updated through the date hereof. Such books fully and correctly
reflect all the decisions of the shareholders. The Company maintains complete
and correct books and records of the Company and its Subsidiaries which fairly
present, in all material respects, the financial position and the results of
operations and cash flows of the Company and its Subsidiaries as of the dates
and for the periods indicated therein, subject to customary and usual audit
adjustments consistently applied.

      3.4 GOVERNMENTAL AUTHORIZATION; NASD AND NASDAQ. Except as otherwise
specifically contemplated in this Agreement and the Transaction Documents, and
except for: (i) the filing of the Registration Statement with the Commission and
(ii) any filings required under SEC Regulation D or any state securities laws
that are permitted to be made after the date hereof, including but not limited
to filings pursuant to Section 25102(f) of the California Corporate Securities
Law of 1968, as amended, and the rules thereunder, the execution, delivery and
performance by the Company of this Agreement and the Transaction Documents, and
the consummation of the transactions contemplated hereby and thereby (including,
but not limited to, the sale and delivery of the Shares and Warrants and the
subsequent issuance of the Warrant Shares upon exercise of the Warrants) by the
Company require no action by or in respect of, or filing with, any governmental
body, agency, official or authority (including the NASD and the NASDAQ Stock
Market).

      3.5 NON-CONTRAVENTION. The execution, delivery and performance by the
Company and its Subsidiaries, as applicable, of this Agreement and the
Transaction Documents, and the consummation by the Company of the transactions
contemplated hereby and thereby (including, but not limited to, the issuance of
the Shares and Warrant Shares) do not and will not (a) violate or conflict with
the Charter and Bylaws of the Company and its Subsidiaries or any material
agreement (which, for purposes of this Agreement, means any agreement, contract
or

                                       8
<PAGE>
other document which the Company would be required to disclose pursuant to SEC
Regulation S-K, Item 601, Exhibits 1, 2, 3, 4, 9 or 10) to which the Company or
any of its Subsidiaries is a party or bound; (b) violate or conflict with or
constitute a material violation of any provision of any law, regulation,
judgment, injunction, order or decree binding upon or applicable to the Company
or any of its Subsidiaries; (c) constitute a default under or give rise to a
right of termination, cancellation or acceleration or loss of any benefit under
any material agreement, contract or other instrument binding upon the Company or
any of its Subsidiaries or under any material license, franchise, permit or
other similar authorization held by the Company or any of its Subsidiaries; or
(d) result in the creation or imposition of any Lien (as defined below) on any
material asset of the Company or any of its Subsidiaries. For purposes of this
Agreement, the term "Lien" means, with respect to any asset, any mortgage, lien,
pledge, charge, security interest, claim or encumbrance of any kind in respect
of such asset.

      3.6 SEC DOCUMENTS. The Company is obligated under the Securities Exchange
Act of 1934, as amended (the "Exchange Act") to file reports pursuant to
Sections 13 and 15(d) thereof (all such reports filed or required to be filed by
the Company, including all exhibits thereto or incorporated therein by
reference, and all documents filed by the Company under the Securities Act are
hereinafter called the "SEC Documents"). The Company has filed all reports or
other documents required to be filed under the Exchange Act. All SEC Documents
filed by the Company (i) were prepared in all material respects in accordance
with the requirements of the Exchange Act and the Securities Act and (ii) did
not at the time they were filed (or, if amended or superseded by a filing prior
to the date hereof, then on the date of such filing) contain any untrue
statement of a material fact or omit to state a material fact required to be
stated therein or necessary in order to make the statements therein, in light of
the circumstances under which they were made, not misleading. The Company has
previously delivered or made available (including via the SEC's EDGAR filing
system) to the Purchaser a correct and complete copy of each report which the
Company filed with the Securities and Exchange Commission (the "SEC" or the
"Commission") under the Exchange Act for any period ending on or after December
31, 2003 (the "Recent Reports," which term includes all exhibits thereto and all
exhibits and other information incorporated by reference into the Recent
Reports). All of the information about the Company or its Subsidiaries which has
been disclosed to the Purchasers herein or in the course of discussions and
negotiations with respect hereto which is material to the Company has been
disclosed in the Recent Reports.

      3.7 FINANCIAL STATEMENTS. Each of the Company's consolidated balance sheet
and related consolidated statements of income, cash flows and changes in
stockholders' equity (including the related notes), as contained in the Recent
Reports (collectively, the "Company's Financial Statements" or the "Financial
Statements") (x) present fairly in all material respects the financial position
of the Company and its consolidated Subsidiaries as of the dates thereof and the
results of operations, cash flows and stockholders' equity as of and for each of
the periods then ended, except that any unaudited financial statements are
subject to normal year-end adjustments, and (y) were prepared in accordance with
United States generally accepted accounting principles ("GAAP") applied on a
consistent basis throughout the periods involved, in each case, except as
otherwise indicated in the notes thereto.

      3.8 COMPLIANCE WITH LAW. The Company and its Subsidiaries are in
compliance and have conducted their business so as to comply in all respects
with all laws, rules and

                                       9
<PAGE>
regulations, judgments, decrees or orders of any court, administrative agency,
commission, self regulatory organization, regulatory authority or other
governmental authority or instrumentality, domestic or foreign, applicable to
its operations except as could not individually or in the aggregate have or
result in a Material Adverse Effect. There are no judgments or orders,
injunctions, decrees, stipulations or awards (whether rendered by a court or
administrative agency or by arbitration), including, without limitation, any
such actions relating to affirmative action claims or claims of discrimination,
against the Company or its Subsidiaries or against any of their properties or
businesses.

      3.9 NO DEFAULTS. The Company and its Subsidiaries are not, nor will they
be with the passage of time, giving of notice, or both, (i) in violation of any
provision of their Charter and Bylaws (ii) in default or violation of any term,
condition or provision of (A) any judgment, decree, order, injunction or
stipulation applicable to the Company or its Subsidiaries or (B) any material
agreement, note, mortgage, indenture, contract, lease or instrument, permit,
concession, franchise or license to which the Company or its Subsidiaries are a
party or by which the Company or its Subsidiaries or their properties or assets
may be bound, and no circumstances exist which would entitle any party to any
material agreement, note, mortgage, indenture, contract, lease or instrument to
which the Company or its Subsidiaries are a party, to terminate such as a result
of the Company or its Subsidiaries, having failed to meet any provision thereof
including, but not limited to, meeting any applicable milestone under any
material agreement or contract.

      3.10 LITIGATION. Except as disclosed in Item 3 of the Company's Annual
Report on Form 10-K for the year ended December 31, 2003, there is no action,
suit, proceeding, judgment, claim or investigation pending or, to the best
knowledge of the Company, threatened against the Company and any of its
Subsidiaries which could, individually or in the aggregate, reasonably be
expected to have a Material Adverse Effect on the Company or its Subsidiaries.
There is no action, suit, proceeding, judgment, claim or investigation pending
or, to the best knowledge of the Company, threatened, which in any manner
challenges or seeks to prevent, enjoin, alter or delay any of the transactions
contemplated hereby, and, to the Company's knowledge, there is no basis for the
assertion of any of the foregoing. There are no claims or complaints existing
or, to the knowledge of the Company or its Subsidiaries, threatened for product
liability in respect of any product of the Company or its Subsidiaries, and the
Company and its Subsidiaries are not aware of any basis for the assertion of any
such claim.

      3.11 ABSENCE OF CERTAIN CHANGES. Since December 31, 2003, the Company has
conducted its business only in the ordinary course and there has not occurred,
except as set forth in the Recent Reports:

      (a) Any event that could reasonably be expected, individually or in the
aggregate, to have a Material Adverse Effect on the Company or any of its
Subsidiaries;

      (b) Any amendments or changes in the Charter or Bylaws of the Company and
its Subsidiaries;

                                       10
<PAGE>
      (c) Any damage, destruction or loss, whether or not covered by insurance,
that would, individually or in the aggregate, have a Material Adverse Effect on
the Company and its Subsidiaries;

      (d) Any

      (i) (A) issuance or sale of any stock, bond or other corporate security or
(B) issuance or sale of any securities convertible into or exchangeable for
securities of the Company, in each case, other than to directors, employees and
consultants pursuant to existing equity compensation or stock purchase plans of
the Company in accordance with past business practices; or

      (ii) sale, assignment or transfer any of its intangible assets except in
the ordinary course of business, or cancellation of any debt or claim except in
the ordinary course of business all in accordance with past practices.

      (e) Any creation, sufferance or assumption by the Company or any of its
Subsidiaries of any Lien on any asset or any making of any loan, advance or
capital contribution to or investment in any Person in an aggregate amount which
exceeds $25,000 outstanding at any time;

      (f) Any entry into, amendment of, relinquishment, termination or
non-renewal by the Company or its Subsidiaries of any material contract,
license, lease, transaction, commitment or other right or obligation, other than
in the ordinary course of business; or

      (g) Any transfer or grant of a right with respect to the patents, patent
applications, patent licenses, trademarks, trade names, service marks, trade
secrets, copyrights or other intellectual property rights owned or licensed by
the Company or its Subsidiaries, except as among the Company and its
Subsidiaries.

      3.12 NO UNDISCLOSED LIABILITIES. The Company and its Subsidiaries do not
have any direct or indirect indebtedness, liabilities, claim, loss, damage,
deficiency, obligation or responsibility, known or unknown, fixed or contingent,
choate or inchoate, liquidated or unliquidated, secured or unsecured, absolute,
accrued or otherwise, whether or not of a kind required by GAAP to be set forth
in financial statements, including but not limited to off-balance sheet
financings, guarantees and similar transactions ("Liabilities") which are not
fully and adequately reflected in the Financial Statements. To the knowledge of
the Company, there are no existing circumstances, conditions, events or
arrangements which may hereafter give rise to any Liabilities of the Company or
its Subsidiaries except in the ordinary course of business.

      3.13 TAXES. All tax returns and tax reports required to be filed with
respect to the income, operations, business or assets of the Company and its
Subsidiaries have been timely filed (or appropriate extensions have been
obtained) with the appropriate governmental agencies in all jurisdictions in
which such returns and reports are required to be filed, and all of the
foregoing as filed are correct and complete and, in all material respects,
reflect accurately all liability for taxes of the Company and its Subsidiaries
for the periods to which such returns relate, and all amounts shown as owing
thereon have been paid. All income, profits, franchise, sales, use, value added,
occupancy, property, excise, payroll, withholding, FICA, FUTA and

                                       11
<PAGE>
other taxes (including interest and penalties), if any, collectible or payable
by the Company and its Subsidiaries or relating to or chargeable against any of
its material assets, revenues or income or relating to any employee, independent
contractor, creditor, stockholder or other third party through the Closing Date,
were fully collected and paid by such date if due by such date or provided for
by adequate reserves in the Financial Statements as of and for the periods ended
December 31, 2003 (other than taxes accruing after such date) and all similar
items due through the Closing Date will have been fully paid by that date or
provided for by adequate reserves, whether or not any such taxes were reported
or reflected in any tax returns or filings. No taxation authority has sought to
audit the records of the Company or any of its Subsidiaries for the purpose of
verifying or disputing any tax returns, reports or related information and
disclosures provided to such taxation authority, or for the Company's or any of
its Subsidiaries' alleged failure to provide any such tax returns, reports or
related information and disclosure. To the knowledge of Company and its
Subsidiaries, no material claims or deficiencies have been asserted against or
inquiries raised with the Company or any of its Subsidiaries with respect to any
taxes or other governmental charges or levies which have not been paid or
otherwise satisfied, including claims that, or inquiries whether, the Company or
any of its Subsidiaries has not filed a tax return that it was required to file,
and there exists no reasonable basis for the making of any such claims or
inquiries. Neither the Company nor any of its Subsidiaries has waived any
restrictions on assessment or collection of taxes or consented to the extension
of any statute of limitations relating to taxation. Neither the Company nor any
of its Subsidiaries is a party to any tax sharing or indemnification agreement,
and none of them is liable for the taxes of any other Person (other than
Subsidiaries) whether as a transferee, successor, by contract or otherwise.

      3.14 INTERESTS OF OFFICERS, DIRECTORS AND OTHER AFFILIATES. The
description of any material interest held, directly or indirectly, by any
officer, director or other Affiliate of Company in any property, real or
personal, tangible or intangible, used in or pertaining to Company's business,
including any interest in the Company's Intellectual Property (as defined in
Section 3.15 hereof), as set forth in the Recent Reports, is true and complete,
and no officer, director or, to the Company's knowledge, other Affiliate of the
Company has any interest in any property, real or personal, tangible or
intangible, used in or pertaining to the Company's business, including the
Company's Intellectual Property, other than as set forth in the Recent Reports.

      3.15 INTELLECTUAL PROPERTY. Other than as set forth in the Recent Reports:
(a) the Company or a Subsidiary thereof has the right to use or is the sole and
exclusive owner of all right, title and interest in and to all foreign and
domestic patents, patent rights, patent applications, trademarks, service marks,
trade names, brands and copyrights (whether or not registered and, if
applicable, including pending applications for registration) owned, used or
controlled by the Company and its Subsidiaries (collectively, the "Rights") and
in and to each material invention, software, trade secret, technology, product,
composition, formula, method of process used by the Company and any intangible
property and assets that are material to the business of the Company or its
Subsidiaries (the Rights and such other items, the "Intellectual Property"), and
has the right to use the same, free and clear of any claim or conflict with the
rights of others; (b) no royalties or fees (license or otherwise) are payable by
the Company or its Subsidiaries to any Person by reason of the ownership or use
of any of the Intellectual Property except as set forth on Schedule 3.15; (c) to
the Company's knowledge, there have been no claims

                                       12
<PAGE>
made against the Company or any Subsidiary asserting the invalidity, abuse,
misuse, or unenforceability of any of the Intellectual Property, and, to each of
their knowledge, there are no reasonable grounds for any such claims; (d)
neither the Company nor any subsidiary has made any claim of any violation or
infringement by others of its rights in the Intellectual Property, and to the
best of their knowledge, no reasonable grounds for such claims exist; and (e)
neither the Company nor any Subsidiary has received any notice that it is in
conflict with or infringing upon the asserted rights of others in connection
with the Intellectual Property, and to the best of their knowledge, no
reasonable grounds for such claims exist. Each of the Company and its
Subsidiaries has taken security measures designed to enable it to assert trade
secret protection in its non-patented technology.

      3.16 RESTRICTIONS ON BUSINESS ACTIVITIES. Other than as set forth in the
Recent Reports, there is no agreement, judgment, injunction, order or decree
binding upon the Company or its Subsidiaries which has or could reasonably be
expected to have the effect of prohibiting or materially impairing any business
practice of the Company or its Subsidiaries, any acquisition of property by the
Company or its Subsidiaries or the conduct of business by the Company or its
Subsidiaries as currently conducted or as currently proposed to be conducted by
the Company or its Subsidiaries.

      3.17 PREEMPTIVE RIGHTS. No Person possesses any preemptive rights,
registration rights or anti-dilution rights, in respect of the Shares or Warrant
Shares to be issued to the Purchasers upon exercise of the Warrants.

      3.18 INSURANCE. The insurance policies providing insurance coverage to the
Company or its Subsidiaries, including for product liability, provide adequate
and customary coverage for the business conducted by the Company and its
Subsidiaries and are sufficient for compliance by the Company and its
Subsidiaries with all requirements of law and all material agreements to which
the Company or its Subsidiaries are a party or by which any of their assets are
bound. All of such policies are with financially sound and reputable insurers
having an "A" rating or better from Best's Rating Service (or any successor
thereto), are in full force and effect and are valid and enforceable in
accordance with their terms, and the Company and its Subsidiaries have complied
with all material terms and conditions of such policies, including, without
limitation, premium payments. None of the insurance carriers has indicated to
the Company or its Subsidiaries an intention to cancel or refuse to renew any
such policy.

      3.19 SUBSIDIARIES AND INVESTMENTS. Except as set forth in the Recent
Reports or on Schedule 3.19, the Company has no Subsidiaries or Investments. For
purposes of this Agreement, the term "Investments" shall mean, with respect to
any Person, all advances, loans or extensions of credit to any other Person, all
purchases or commitments to purchase any stock, bonds, notes, debentures or
other securities of any other Person, and any other investment in any other
Person, including partnerships or joint ventures (whether by capital
contribution or otherwise) or other similar arrangement (whether written or
oral) with any Person, including but not limited to arrangements in which (i)
the Person shares profits and losses, (ii) any such other Person has the right
to obligate or bind the Person to any third party, or (iii) the Person may be
wholly or partially liable for the debts or obligations of such partnership,
joint venture or other arrangement.

                                       13
<PAGE>
      3.20 CAPITALIZATION. (a) The authorized capital stock of the Company
consists of 50,000,000 shares of common stock, $0.001 par value per share, of
which 10,010,048 shares are issued and outstanding as of the date hereof, and
5,000,000 shares of preferred stock, issuable in one or more classes or series,
with such relative rights and preferences as the Board of Directors may
determine, none of which has been authorized for issuance or designated and
provided with terms, other than as follows:

      (i) 400 shares have been designated 5% Series A Preferred Stock, of which
no shares are outstanding and as to which there is no obligation (including any
contingent obligation) to issue any such shares;

      (ii) 200,000 shares have been designated Series B Junior Participating
Preferred Stock, of which no shares are outstanding and as to which there is no
obligation (including any contingent obligation) to issue any such shares, other
than pursuant to the Rights Agreement by and between the Company and U.S. Stock
Transfer Corporation (the "Rights Plan");

      (iii) 200 shares have been designated 7% Series C Preferred Stock, of
which no shares are outstanding and as to which there is no obligation
(including any contingent obligation) to issue any such shares;

      (iv) 600 shares have been designated Series D 8% Cumulative Convertible
Voting Preferred Stock (the "Series D Preferred Stock"), of which 265 shares are
outstanding and as to which there is no obligation (including any contingent
obligation) to issue any such shares; and

      (v) 2000 shares have been designated as the Series E Convertible Voting
Preferred Stock (the "Series E Preferred Stock"), of which 486 shares are
outstanding and as to which there is no obligation (including any contingent
obligation) to issue any such shares.

      (b) All shares of the Company's issued and outstanding capital stock have
been duly authorized, are validly issued and outstanding, and are fully paid and
nonassessable. No securities issued by the Company from January 1, 2000 to the
date hereof were issued in violation of any statutory, contractual or common law
preemptive rights. There are no dividends which have accrued or been declared
but are unpaid on the capital stock of the Company other than dividends on the
Series D Preferred Stock. All taxes required to be paid by Company in connection
with the issuance and any transfers of the Company's capital stock have been
paid. All permits or authorizations required to be obtained from or
registrations required to be effected with any Person in connection with any and
all issuances of securities of the Company from January 1, 2000, to the date
hereof have been obtained or effected, and all securities of the Company issued
on or after January 1, 2000, have been issued in accordance with the provisions
of all applicable securities or other laws.

      3.21 OPTIONS, WARRANTS, RIGHTS. Except as set forth on Schedule 3.21,
there are no outstanding (a) securities, notes or instruments convertible into
or exercisable for any of the capital stock or other equity interests of the
Company or its Subsidiaries; (b) options, warrants, subscriptions or other
rights to acquire capital stock or other equity interests of the Company or its
Subsidiaries; or (c) commitments, agreements or understandings of any kind,
including employee benefit arrangements, relating to the issuance or repurchase
by the Company or its

                                       14
<PAGE>
Subsidiaries of any capital stock or other equity interests of the Company or
its Subsidiaries, any such securities or instruments convertible into or
exercisable for securities or any such options, warrants or rights. Except as
set forth on Schedule 3.21, neither the Company nor any Subsidiary has granted
anti-dilution rights to any person or entity in connection with any option,
warrant, subscription or any other instrument convertible into or exercisable
for the securities of the Company or any of its Subsidiaries. Other than the
rights granted to the Purchasers under the Investor Rights Agreement, there are
no outstanding rights which permit the holder thereof to cause the Company or
the Subsidiaries to file a registration statement under the Securities Act or
which permit the holder thereof to include securities of the Company or any of
its Subsidiaries in a registration statement filed by the Company or any of its
Subsidiaries under the Securities Act, and there are no outstanding agreements
or other commitments which otherwise relate to the registration of any
securities of the Company or any of its Subsidiaries for sale or distribution in
any jurisdiction, except as set forth on Schedule 3.21.

      3.22 EMPLOYEES, EMPLOYMENT AGREEMENTS AND EMPLOYEE BENEFIT PLANS. (a)
Except as set forth in the Recent Reports or on Schedule 3.22, there are no
material employment, consulting, severance or indemnification arrangements,
agreements, or understandings between the Company or its Subsidiaries and any
officer, director, consultant or employee of the Company or its Subsidiaries
(the "Employment Agreements"). Except as set forth in the Recent Reports or on
Schedule 3.22, no Employment Agreement provides for the acceleration or change
in the award, grant, vesting or determination of options, warrants, rights,
severance payments, or other contingent obligations of any nature whatsoever of
the Company or its Subsidiaries in favor of any such parties in connection with
the transactions contemplated by this Agreement. Except as disclosed in the
Recent Reports or on Schedule 3.22, the terms of employment or engagement of all
directors, officers, employees, agents, consultants and professional advisors of
the Company and its Subsidiaries are such that their employment or engagement
may be terminated upon not more than two weeks' notice given at any time without
liability for payment of compensation or damages and the Company and its
Subsidiaries have not entered into any agreement or arrangement for the
management of their business or any part thereof other than with their directors
or employees.

      (b) Except as set forth on Schedule 3.22, the Company and its Subsidiaries
have no pension, retirement, stock purchase, stock bonus, stock ownership, stock
option, profit sharing, savings, medical, disability, hospitalization,
insurance, deferred compensation, bonus, incentive, welfare or any other
employee benefit plan, policy, agreement, commitment, arrangement or practice
currently or previously maintained or contributed to by the Company or its
Subsidiaries for any of its directors, officers, consultants, employees or
former employees (the "Company Plans"). The Company has previously made
available to the Purchasers, to the extent applicable, (i) a true and complete
copy of all of the Company Plans (or, if oral, a true and complete written
summary thereof); (ii) a current summary plan description (plus summaries of any
subsequent modifications thereto) for each Company Plan; (iii) the latest IRS
determination letter obtained with respect to any Company Plan qualified under
Section 401 or 501 of the Code; and (iv) Forms 5500 for the last three (3) plan
years for each Company Plan required to file such form. Except as set forth on
Schedule 3.22, none of the Company Plans is subject to the Employee Retirement
Income Security Act of 1974, as amended ("ERISA"), and, except as set forth on
Schedule 3.22, neither the Company nor any of its Subsidiaries has established,
maintained, made or been required to make any contributions to, or terminated,
and has no

                                       15
<PAGE>
liability with respect to, any "employee benefit plan" within the meaning of
ERISA. The Company and its Subsidiaries have not incurred any liability to the
Pension Benefit Guaranty Corporation (the "PBGC"), and, to the Company's
knowledge, no facts or circumstances exist which might give rise to any
liability of the Company or its Subsidiaries to the PBGC or which could
reasonably be anticipated to result in any claims being made against the
Purchaser, the Company or their Subsidiaries by the PBGC. To the Company's
knowledge, no facts or circumstances exist which might give rise to any
liability of any Company Plan to any other Person, other than in the ordinary
course of the Company's business. The Company and its Subsidiaries have paid all
amounts required under applicable law and any Company Plan to be paid as a
contribution to any Company Plan through the date hereof. The Company has set
aside adequate reserves to meet contributions which are not yet due under any
Company Plan. Neither the Company, nor its Subsidiaries nor, to the Company's
knowledge, any other Person has engaged in any transaction with respect to any
Company Plan which would subject the Company to any tax, penalty or liability
for prohibited transactions. No director, officer or employee of the Company or
its Subsidiaries, to the extent he or she is a fiduciary with respect to any
Company Plan, has breached any of his/her responsibilities or obligations
imposed upon fiduciaries or which could result in any claim being made under, by
or on behalf of any Company Plan. No Company Plan provides post-employment
medical, health, or life insurance benefits for present or future retirees or
present or future terminated employees, except for continuation coverage
provided pursuant to the requirements of Section 4980B of the Code or Sections
601-608 of ERISA or a similar state law.

      (c) No material labor dispute with employees of the Company exists or, to
the best knowledge of the Company is imminent.

      3.23 ABSENCE OF CERTAIN BUSINESS PRACTICES. Neither the Company, nor any
Affiliate of the Company (including, but not limited to, its Subsidiaries), nor
any agent or employee of the Company, any other Person acting on behalf of or
associated with the Company, or any individual related to any of the foregoing
Persons, acting on behalf of the Company alone or together, has: (a) received,
directly or indirectly, any rebates, payments, commissions, promotional
allowances or any other economic benefits, regardless of their nature or type,
from any customer, supplier, trading company, shipping company, governmental
employee or other Person with whom the Company or its Subsidiaries has done
business directly or indirectly; or (b) directly or indirectly, given or agreed
to give any gift or similar benefit to any customer, supplier, trading company,
shipping company, governmental employee or other Person who is or may be in a
position to help or hinder the business of the Company or its Subsidiaries (or
assist the Company or its Subsidiaries in connection with any actual or proposed
transaction) which (i) may subject the Company or its Subsidiaries to any damage
or penalty in any civil, criminal or governmental litigation or proceeding, (ii)
if not given in the past, may have had an adverse effect on the Company or its
Subsidiaries or (iii) if not continued in the future, may adversely affect the
assets, business, operations or prospects of the Company or its Subsidiaries or
subject the Company or its Subsidiaries to suit or penalty in any private or
governmental litigation or proceeding.

      3.24 PRODUCTS AND SERVICES. There exists no set of facts (i) which could
furnish a basis for the withdrawal, suspension or cancellation of any
registration, license, permit or other governmental approval or consent of any
governmental or regulatory agency issued to the

                                       16
<PAGE>
Company with respect to any component of any product being developed by, or that
is material to and used by, the Company or its Subsidiaries, or (ii) which could
have a Material Adverse Effect on the continued development of any product
candidate of the Company or its Subsidiaries or which could otherwise cause the
Company or its Subsidiaries to withdraw, suspend or cancel development of any
such product, it being understood that the Company is not presently offering any
product or service for sale and has never in the past offered any product or
service for sale, and that the Company's product candidates will require, before
they can be offered for commercial sale, certain governmental or regulatory
licenses, permits or approvals which have not been issued.

      3.25 ENVIRONMENTAL MATTERS. None of the premises or any other property
owned, occupied or leased by the Company or its Subsidiaries (the "Premises") in
the past has been used by the Company or its Subsidiaries, or to the Company's
knowledge, by any other Person, to manufacture, treat, utilize, store, or
dispose of any waste, pollutant or toxic or hazardous substance (including,
without limitation, asbestos, radioactive material and pesticides) or any other
substance that has been designated to be a "hazardous substance" under
Environmental Laws ("Hazardous Substances") other than substances customarily
used in the Company's or its Subsidiaries' businesses and in accordance with
applications laws and regulations. The Company and its Subsidiaries have not
disposed of, discharged, emitted or released any Hazardous Substances which
would require, under applicable Environmental Laws, remediation, investigation
or similar response activity. No Hazardous Substances are present as a result of
the actions of the Company or its Subsidiaries or, to the Company's or its
Subsidiaries' knowledge, any other Person, in, on or under the Premises which
would give rise to any liability or clean-up obligations of the Company or its
Subsidiaries under applicable Environmental Laws. The Company and its
Subsidiaries and, to the Company's and its Subsidiaries' knowledge, any other
Person for whose conduct it may be responsible, are in material compliance with
all laws, regulations and other federal, state or local governmental
requirements, and all applicable judgments, orders, writs, notices, decrees,
permits, licenses, approvals, consents or injunctions in effect on the
applicable Closing Date relating to the generation, management, handling,
transportation, treatment, disposal, storage, delivery, discharge, release or
emission of any waste, pollutant or toxic or hazardous substance (including,
without limitation, asbestos, radioactive material and pesticides) or to any
other actions, omissions or conditions affecting the environment (the
"Environmental Laws"). Neither the Company nor its Subsidiaries nor, to the
Company's or its Subsidiaries' knowledge, any other Person for whose conduct it
may be responsible has received any complaint, notice, order, or citation of any
actual, threatened or alleged noncompliance with any of the Environmental Laws,
and there is no proceeding, suit or investigation pending or, to the Company's
or its Subsidiaries knowledge, threatened against the Company or its
Subsidiaries or any such Person with respect to any violation or alleged
violation of the Environmental Laws, and there is no basis for the institution
of any such proceeding, suit or investigation.

      3.26 LICENSES; COMPLIANCE WITH FDA AND OTHER REGULATORY REQUIREMENTS.

      (a) GENERAL. The Company and its Subsidiaries hold all authorizations,
consents, approvals, franchises, licenses and permits required under applicable
law or regulation for the operation of the business of the Company and its
Subsidiaries as presently operated (the "Governmental Authorizations"). All the
Governmental Authorizations have been duly issued or

                                       17
<PAGE>
obtained and are in full force and effect, and the Company and its Subsidiaries
are in compliance with the terms of all the Governmental Authorizations. The
Company and its Subsidiaries have not engaged in any activity that could cause
revocation or suspension of any such Governmental Authorizations. The Company
and its Subsidiaries have no knowledge of any facts which could reasonably be
expected to cause them to believe that the Governmental Authorizations will not
be renewed by the appropriate governmental authorities in the ordinary course.
Neither the execution, delivery nor performance of this Agreement will adversely
affect the status of any of the Governmental Authorizations.

      (b) FDA. Without limiting the generality of the representations and
warranties made in paragraph (a) above, the Company represents and warrants that
(i) the Company and each of its Subsidiaries is in compliance in all material
respects with all applicable provisions of the United States Federal Food, Drug,
and Cosmetic Act (the "FDC Act"), (ii) the Company and each of its Subsidiaries
is in compliance with the following specific requirements: (A) all of the
products used by the Company and its Subsidiaries comply in all material
respects with any conditions of approval and the terms of the applications, if
any, submitted by or on behalf of the Company to the United States Food and Drug
Administration (the "FDA"); (B) all adverse events that were required to be
reported by Company or its Subsidiaries to the FDA have been reported to the FDA
in a timely manner; (C) neither the Company nor any of its Subsidiaries is, to
their knowledge, employing or utilizing the services of any individual who has
been debarred under the FDC Act; (D) all stability studies required to be
performed by or on behalf of the Company for products used by the Company or any
of its Subsidiaries have been completed or are ongoing in accordance with the
applicable FDA requirements; and (E) any substances exported by the Company or
any of its Subsidiaries have been exported in compliance in all material
respects with the FDC Act. Without limiting the generality of the
representations and warranties made in paragraph (a) above, the Company and its
Subsidiaries are in compliance in all material respects with all applicable
provisions of the Controlled Substances Act.

      3.27 BROKERS. Except as set forth in Schedule 3.27 hereto, no broker,
finder or investment banker is entitled to any brokerage, finder's or other fee
or commission in connection with the transactions contemplated by this
Agreement, based upon any arrangement made by or on behalf of the Company or any
of its Affiliates.

      3.28 SECURITIES LAWS. Neither the Company nor its Subsidiaries nor any
agent acting on behalf of the Company or its Subsidiaries has taken or will take
any action which might cause this Agreement or any of the Securities to violate
the Securities Act or the Exchange Act or any rules or regulations promulgated
thereunder, or any applicable state securities laws, as in effect on the Closing
Date. All offers and sales of capital stock, securities and notes of the Company
were conducted and completed in compliance with the Securities Act, the rules
and regulations promulgated thereunder and applicable state securities laws. All
shares of capital stock and other securities issued by the Company and its
Subsidiaries prior to the date hereof have been issued in transactions that were
either registered offerings or were exempt from the registration requirements
under the Securities Act and all applicable state securities laws and in
compliance with all applicable corporate laws.

      3.29 DISCLOSURE. No representation or warranty made by the Company in this
Agreement, nor in any document, written information, financial statement,
certificate, schedule

                                       18
<PAGE>
or exhibit prepared and furnished by the Company pursuant hereto or in
connection with the transactions contemplated hereby, contains or will contain
any untrue statement of a material fact, or omits to state a material fact
necessary to make the statements or facts contained herein or therein not
misleading in light of the circumstances under which they were made.

      3.30 CHANGE IN CONTROL. Assuming that there are no contractual agreements
(other than this Agreement) among any two or more of the Purchasers with respect
to the purchase, sale or other disposition, or voting of the equity securities
of the Company, the execution, delivery and performance of this Agreement and
the Transaction Documents, and the consummation of the transactions contemplated
hereby and thereby (including the exercise of some or all of the Warrants and
the issuance of the Warrant Shares) do not and will not constitute a change in
control under or give rise to a right of termination, cancellation, severance or
similar payments, or acceleration or loss of any benefit under any material
agreement, contract or other instrument binding upon the Company or any of its
Subsidiaries, under any material license, franchise, permit or other similar
authorization held by the Company or any of its Subsidiaries or under any
agreement or arrangement between the Company or any of its Subsidiaries and
their directors, officers, employees or consultants.

      3.31 APPLICATION OF TAKEOVER PROTECTION. The Company and its board of
directors have taken all necessary action in order to render inapplicable, and
have rendered inapplicable, any control share acquisition, business combination,
poison pill (including any distribution under a rights agreement) or other
similar anti- takeover provision under the Charter, the By-laws, the laws of the
state of its incorporation or any rights plan or similar arrangement which is or
could become applicable as a result of the transactions contemplated by this
Agreement, including, without limitation, the Company's issuance of the
Securities and the Purchasers' ownership of the Shares, the Warrants or the
Warrant Shares.

      3.32 NASDAQ COMPLIANCE. The Common Stock is registered pursuant to Section
12(g) of the Exchange Act, and is listed on the NASDAQ SmallCap Market (the
"NASDAQ Stock Market"), and the Company has taken no action designed to, or
which to its knowledge is likely to have the effect of, terminating the
registration of the Common Stock under the Exchange Act or delisting the Common
Stock from the NASDAQ Stock Market. The issuance of the Securities does not
require stockholder approval, including, without limitation, pursuant to the
NASDAQ Marketplace Rules as in effect on the Closing Date, including without
limitation all Interpretive Materials issued on or before the Closing Date. No
order ceasing or suspending trading in any securities of Company or prohibiting
the issuance and/or sale of the Shares, Warrants or Warrant Shares is in effect
and no proceedings for such purpose are pending or, to the Company's knowledge,
threatened.

      3.33 MATERIAL CONTRACTS. Each of the Company's and its Subsidiaries
material contracts (which, for purposes of this Agreement, means any agreement,
contract or other document which the Company would be required to disclose
pursuant to SEC Regulation S-K, Item 601, Exhibits 1, 2, 3, 4, 9 or 10) are
listed as exhibits to the Recent Reports and are in full force and effect on the
date hereof, and none of the Company, its Subsidiaries nor, to the Company's or
any Subsidiary's knowledge, any other party to such contracts is in breach of or
default under any of such contracts. The Company is not required to file and
will not be required to file any agreement, note, lease, mortgage, deed or other
instrument entered into by the

                                       19
<PAGE>
Company or any Subsidiary prior to the date hereof which has not been previously
filed as an exhibit to its Recent Reports.

      3.34 TITLE TO AND CONDITION OF PERSONAL PROPERTY; NO LIENS. The Company
and its Subsidiaries have good and valid title to, or, in the case of leased
properties and assets, valid leasehold interests in, all of their tangible
properties and assets, real, personal and mixed, used in their business, free
and clear of any Liens, except as set forth on Schedule 3.34. All tangible
personal property owned by the Company and its Subsidiaries is in good operating
condition and in a good state of maintenance and repair, and is adequate for the
business conducted and proposed to be conducted by the Company and its
Subsidiaries. Except for the Leases specifically identified in Schedule 3.34,
there are no assets owned by any third party which are material to the operation
of the business of the Company or its Subsidiaries, as presently conducted or
proposed to be conducted.

                                   ARTICLE IV

                  REPRESENTATIONS AND WARRANTIES OF PURCHASERS

      Each Purchaser, for itself, hereby severally, and not jointly, represents
and warrants to the Company as follows:

      4.1 EXISTENCE AND POWER. The Purchaser is duly organized, validly existing
and in good standing under the laws of the jurisdiction of such Purchaser's
organization. The Purchaser has all powers required to carry on such Purchaser's
business as now conducted.

      4.2 AUTHORIZATION. The execution, delivery and performance by the
Purchaser of this Agreement, the Transaction Documents to which such Purchaser
is a party, and the consummation by the Purchaser of the transactions
contemplated hereby have been duly authorized, and no additional action is
required for the approval of this Agreement. This Agreement and the Transaction
Documents to which the Purchaser is a party have been or, to the extent
contemplated hereby, will be duly executed and delivered and constitute valid
and binding agreements of the Purchaser, enforceable against such Purchaser in
accordance with their terms, except as may be limited by bankruptcy,
reorganization, insolvency, moratorium and similar laws of general application
relating to or affecting the enforcement of rights of creditors and except that
enforceability of their obligations thereunder are subject to general principles
of equity.

      4.3 INVESTMENT. The Purchaser is acquiring the Securities for its own
account for investment and not with a view to, or for sale in connection with,
any distribution thereof, nor with the intention of distributing or reselling
the same, provided, however, that by making the representation herein, the
Purchaser does not agree to hold any of the securities for any minimum or other
specific term and reserves the right to dispose of the Securities at any time in
accordance with or pursuant to a registration statement or an exemption under
the Securities Act. The Purchaser is aware that none of the Securities has been
registered under the Securities Act or under applicable state securities or blue
sky laws. The Purchaser is an "Accredited Investor" as such term is defined in
Rule 501 of Regulation D, as promulgated under the Securities Act.

                                       20
<PAGE>
      4.4 NONCONTRAVENTION. Neither the execution and the delivery of this
Agreement, nor the consummation of the transactions contemplated hereby, will
violate any constitution, statute, regulation, rule, injunction, judgment,
order, decree, ruling, charge, or other restriction of any government,
governmental agency, or court to which Purchaser is subject or any provision of
its charter or bylaws or other similar governing instruments.

      4.5 NO REGISTRATION. The Purchaser understands that the Shares and
Warrants are being offered and sold to such Purchaser in reliance upon specific
exemptions from the registration requirements of United States federal and state
securities laws and that the Company is relying upon the truth and accuracy of,
and such Purchaser's compliance with, the representations, warranties,
agreements, acknowledgments and understandings of such Purchaser set forth
herein in order to determine the availability of such exemptions and the
eligibility of such Purchaser to acquire the Securities.

      4.6 BUSINESS OR FINANCIAL EXPERTISE. Purchaser has, by reason of
Purchaser's business or financial expertise or the business or financial
experience of its professional advisors who are unaffiliated with and who are
not, to such Purchaser's knowledge, compensated by the Company or any affiliate
or selling agent of the Company, directly or indirectly, the capacity to protect
its own interests in connection with its acquisition of the Securities.
Purchaser has had the opportunity to ask questions about the Company's business
affairs and financial condition, and has acquired sufficient information about
the Company to reach an informed and knowledgeable decision to acquire the
Securities.

      4.7 SHORT SELLING. Neither Purchaser nor any Affiliate of such Purchaser
which: (i) had knowledge of the transactions contemplated hereby; (ii) has or
shares discretion relating to such Purchaser's investments or trading or
information concerning such Purchaser's investments, including in respect of the
Securities; or (iii) is subject to such Purchaser's review or input concerning
such Affiliate's investments or trading, has made or will make, directly or
indirectly, any net short sale of the Company's Common Stock for the period
beginning on the fifteenth (15th) day prior to the date of this Agreement and
ending on the earlier of (a) the Closing Date or (b) the date that the
transactions contemplated by this Agreement are publicly announced. For purposes
of this Section 4.7, a "net short sale" by any Purchaser shall mean a sale of
Common Stock by such Purchaser that is marked as a short sale and that is made
at a time when there is no equivalent offsetting long position in Common Stock
held by such Purchaser, where an "equivalent offsetting long position" includes
all shares of Common Stock held by such Purchaser and all underlying shares of
Common Stock which are issuable upon conversion, exercise or exchange of
convertible securities, warrants, options or other rights to subscribe for or to
purchase or exchange for shares of Common Stock.

      4.8 BROKERS' FEES. Purchaser has no liability or obligation to pay any
fees or commissions to any broker, finder, or agent with respect to the
transactions contemplated by this Agreement for which the Company could become
liable or obligated.

                                       21
<PAGE>
                                    ARTICLE V

                         OTHER AGREEMENTS OF THE PARTIES

      5.1 TRANSFER RESTRICTIONS.

      (a) The Securities may only be disposed of in compliance with state and
federal securities laws. In connection with any transfer of Securities other
than pursuant to an effective registration statement, to the Company, to an
Affiliate of a Purchaser (who is an accredited investor and executes a customary
representation letter) or in connection with a pledge as contemplated in Section
5.1(b), the Company may require the transferor thereof to provide to the Company
an opinion of counsel reasonably satisfactory to the Company selected by the
transferor, the form and substance of which opinion shall be reasonably
satisfactory to the Company, to the effect that such transfer does not require
registration of such transferred Securities under the Securities Act, provided,
however, that in the case of a transfer pursuant to Rule 144, no opinion shall
be required if the transferor provides the Company with a customary seller's
representation letter, and if such sale is not pursuant to subsection (k) of
Rule 144, a customary broker's representation letter and a Form 144. Any such
transferee that agrees in writing to be bound by the terms of this Agreement and
the Investor Rights Agreement shall have the rights of a Purchaser under this
Agreement and the Investor Rights Agreement. Except as required by this
Agreement, federal securities laws and the securities law of any state or other
jurisdiction within the United States, the Securities may be transferred, in
whole or in part, by any of the Purchasers at any time. The Company shall
reissue certificates evidencing the Securities upon surrender of certificates
evidencing the Securities being transferred in accordance with this Section
5.1(a).

      (b) The Purchasers agree to the imprinting, so long as is required by this
Section 5.1(b), of a legend on any of the Securities in substantially the
following form:

      "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE OFFERED OR SOLD IN THE
ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER SAID ACT UNLESS, IN THE
OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY, SUCH REGISTRATION IS
NOT REQUIRED."

      The Company acknowledges and agrees that a Purchaser may from time to time
pledge pursuant to a bona fide margin agreement with a registered broker-dealer
or grant a security interest in some or all of the Securities to a financial
institution that is an "accredited investor" as defined in Rule 501(a) under the
Securities Act and, if required under the terms of such arrangement, such
Purchaser may transfer pledged or secured Securities to the pledgees or secured
parties. Such a pledge or transfer would not be subject to approval of the
Company and no legal opinion of legal counsel of the pledgee, secured party or
pledgor shall be required in connection therewith; provided, however, that such
Purchaser shall provide the Company with such documentation as is reasonably
requested by the Company to ensure that the pledge is pursuant to a bona fide
margin agreement with a registered broker-dealer or a security interest in some
or all of the Securities to a financial institution that is an "accredited
investor" as defined in Rule 501(a) under the Securities Act. The Company will
execute and deliver such documentation as a pledgee or secured party of
Securities may reasonably request in connection

                                       22
<PAGE>
with a pledge or transfer of the Securities, including the preparation and
filing of any required prospectus supplement under Rule 424(b)(3) under the
Securities Act or other applicable provision of the Securities Act to
appropriately amend the list of selling stockholders thereunder.

      (c) Certificates evidencing the Shares and Warrant Shares shall not
contain any legend (including the legend set forth in Section 5.1(b)), (i)
following any sale of such Shares or Warrant Shares pursuant to Rule 144, or
(ii) if such Shares or Warrant Shares are eligible for sale under Rule 144(k),
or (iii) if such legend is not required under applicable requirements of the
Securities Act (including judicial interpretations and pronouncements issued by
the Staff of the Commission). The Company shall, if required by the Company's
transfer agent in order to remove such legend as provided in the preceding
sentence and subject to the receipt from the Purchaser of the Necessary
Documentation (as defined below), (x) cause its counsel to issue a legal opinion
to the Company's transfer agent promptly upon the occurrence of any of the
events in clauses (i), (ii) or (iii) above to effect the removal of the legend
hereunder and (y) provide such other instructions or documentation as may be
necessary from the Company for such purpose. The Company shall also cause its
counsel to issue a legal opinion to the Company's transfer agent promptly after
the Effective Date, (or from time to time after the Effective Date, if
necessary) if required by the Company's transfer agent, and shall provide such
other instructions or documentation as may be necessary from the Company to
allow sales pursuant to an effective Registration Statement, provided that the
Purchaser shall represent with respect to each sale that it makes, that it has
complied with the prospectus delivery requirements under the Securities Act. The
Company agrees that at such time as such legend is no longer required under this
Section 5.1(c), it will, no later than three Trading Days following the delivery
by a Purchaser to the Company or the Company's transfer agent of a certificate
representing Shares or Warrant Shares, as the case may be, issued with a
restrictive legend, deliver or cause to be delivered to such Purchaser a
certificate representing such Securities that is free from all restrictive and
other legends. The Company may not make any notation on its records or give
instructions to any transfer agent of the Company that enlarge the restrictions
on transfer set forth in this Section. "Necessary Documentation" means (A) with
respect to sales described in Section 5.1(c)(i), a customary broker's
representation letter and a customary seller's representation letter, (B) with
respect to sales described in Section 5.1(c)(ii), a customary 144(k) seller's
representation letter, or (C) with respect to Section 5.1(c)(iii), such
documentation as may be necessary to establish the satisfaction of the
conditions to removal of the legend.

      (d) Each Purchaser, severally and not jointly, agrees that the removal of
the restrictive legend from certificates representing Securities as set forth in
this Section 5.1 is predicated upon the Company's reliance on, and the
Purchaser's agreement that, and each Purchaser hereby agrees that, the Purchaser
will not sell any Securities except pursuant to either the registration
requirements of the Securities Act, including any applicable prospectus delivery
requirements, or an exemption therefrom.

      5.2 FURNISHING OF INFORMATION.

      As long as the Purchasers collectively own at least 5% of the Shares sold
pursuant to this Agreement and Warrants or Warrant Shares representing at least
5% of the Warrant Shares originally issuable upon exercise of all Warrants
issued pursuant to this Agreement, if the Company is not required to file
reports pursuant to the Exchange Act, it will prepare and furnish

                                       23
<PAGE>
to the Purchasers and make publicly available in accordance with Rule 144(c),
such information as is required for the Purchasers to sell the Securities under
Rule 144. The Company further covenants that it will take such further action as
any holder of Securities may reasonably request, all to the extent required from
time to time to enable such Person to sell such Securities without registration
under the Securities Act within the limitation of the exemptions provided by
Rule 144.

      5.3 INTEGRATION.

      The Company shall not sell, offer for sale or solicit offers to buy or
otherwise negotiate in respect of any security (as defined in Section 2 of the
Securities Act) that would be integrated with the offer or sale of the
Securities in a manner that would require the registration under the Securities
Act of the sale of the Securities to the Purchasers or that would be integrated
with the offer or sale of the Securities for purposes of the rules and
regulations of any Trading Market.

      5.4 PUBLICITY.

      The Company shall, within two Business Days following the Closing Date,
file a Current Report on Form 8-K, disclosing the transactions contemplated
hereby and make such other filings and notices in the manner and time required
by the Commission. The Company and the Placement Agent shall consult with each
other in issuing any press releases with respect to the transactions
contemplated hereby, and neither the Company nor any Purchaser nor the Placement
Agent shall issue any such press release or otherwise make any such public
statement without the prior consent of the Company, with respect to any press
release of any Purchaser or the Placement Agent, or without the prior consent of
the Placement Agent, with respect to any press release of the Company, except if
such disclosure is required by law, in which case the disclosing party shall
promptly provide the other party with prior notice of such public statement or
communication.

      5.5 NON-PUBLIC INFORMATION.

      The Company covenants and agrees that neither it nor any other Person
acting on its behalf will provide any Purchaser or its agents or counsel with
any information that the Company believes constitutes material non-public
information, unless prior thereto such Purchaser shall have executed a written
agreement regarding the confidentiality and use of such information. The Company
understands and confirms that each Purchaser shall be relying on the foregoing
representations in effecting transactions in securities of the Company.

      5.6 USE OF PROCEEDS.

      The Company covenants and agrees that the proceeds from the sale of the
Common Stock and Warrants shall be used by the Company for working capital and
general corporate purposes.

      5.7 RESERVATION OF COMMON STOCK.

      As of the date hereof, the Company has reserved and the Company shall
continue to reserve and keep available at all times, free of preemptive rights,
a sufficient number of shares of

                                       24
<PAGE>
Common Stock for the purpose of enabling the Company to issue Shares pursuant to
this Agreement and Warrant Shares pursuant to the Warrants.

      5.8 LISTING OF COMMON STOCK.

      The Company hereby agrees to use best efforts to list the Shares and
Warrant Shares on any Trading Market on which the Common Stock is listed as of
the Closing Date. The Company further agrees, if the Company applies to have the
Common Stock traded on any other Trading Market, it will include in such
application the Shares and the Warrant Shares, and will take such other action
as is necessary to cause the Shares and Warrant Shares to be listed on such
other Trading Market as promptly as possible.

      5.9 SECURITIES LAW COMPLIANCE.

      (a) SECURITIES ACT. The Company shall timely prepare and file with the
Securities and Exchange Commission the form of notice of the sale of securities
pursuant to the requirements of Regulation D regarding the sale of the Common
Stock and Warrants under this Agreement.

      (b) STATE SECURITIES LAW COMPLIANCE -- SALE. The Company shall timely
prepare and file such applications, consents to service of process (but not
including a general consent to service of process) and similar documents and
take such other steps and perform such further acts as shall be required by the
state securities law requirements of each jurisdiction where a Purchaser
resides, as indicated on Schedule 1, with respect to the sale of the Common
Stock and Warrants under this Agreement.

      (c) STATE SECURITIES LAW COMPLIANCE --RESALE. Beginning no later than 30
days following the date of this Agreement and continuing until either (i) the
purchasers have sold all of their Shares and Warrant Shares under a registration
statement pursuant to the Investor Rights Agreement or (ii) the Common Stock
becomes a "covered security" under Section 18(b)(1)(A) of the Securities Act,
the Company shall maintain within either Moody's Industrial Manual or Standard
and Poor's Standard Corporation Descriptions (or any successors to these manuals
which are similarly qualified as "recognized securities manuals" under state
Blue Sky laws) an updated listing containing (i) the names of the officers and
directors of the Company, (ii) a balance sheet of the Company as of a date that
is at no time older than eighteen months and (iii) a profit and loss statement
of the Company for either the preceding fiscal year or the most recent year of
operations.

      5.10 SHORT SALES.

      Each Purchaser agrees that it will not use any of the Shares or Warrant
Shares acquired pursuant to this Agreement to cover any short position in the
Common Stock if doing so would be in violation of applicable securities laws.
Each Purchaser acknowledges that it is aware that the Commission has published
its position that covering a short position established prior to effectiveness
of a resale registration statement with shares included in such registration
statement would be a violation of Section 5 of the Securities Act.

                                       25
<PAGE>

                                   ARTICLE VI

                    INDEMNIFICATION, TERMINATION AND DAMAGES

      6.1 SURVIVAL OF REPRESENTATIONS.

      Except as otherwise provided herein, the representations and warranties of
the Company and the Purchasers contained in or made pursuant to this Agreement
shall survive the execution and delivery of this Agreement and the Closing Date
and shall continue in full force and effect for a period of two (2) years from
the Closing Date. The Company's and the Purchasers' warranties and
representations shall in no way be affected or diminished in any way by any
investigation of (or failure to investigate) the subject matter thereof made by
or on behalf of the Company or the Purchasers.

      6.2 INDEMNIFICATION.

      (a) The Company agrees to indemnify and hold harmless the Purchasers,
their Affiliates, each of their officers, directors, employees and agents and
their respective successors and assigns, from and against any losses, damages,
or expenses (net of any related insurance proceeds) due to any third party
actions, suits, proceedings, claims, demands, judgments, costs and expenses
(including reasonable legal fees and expenses)(collectively, "Third Party
Claims") which are caused by or arise out of (i) any breach or default in the
performance by the Company of any covenant or agreement made by the Company in
this Agreement or in any of the Transaction Documents or (ii) any breach of
warranty or representation made by the Company in this Agreement or in any of
the Transaction Documents.

      (b) The Purchasers, severally and not jointly, agree to indemnify and hold
harmless the Company, its Affiliates, each of their officers, directors,
employees and agents and their respective successors and assigns, from and
against any Third Party Claims which are caused by or arise out of (i) any
breach or default in the performance by the Purchasers of any covenant or
agreement made by the Purchasers in this Agreement or in any of the Transaction
Documents or (ii) any breach of warranty or representation made by the
Purchasers in this Agreement or in any of the Transaction Documents; provided,
however, that a Purchaser's liability under this Section 6.2(b) shall not exceed
the Purchase Price paid by such Purchaser hereunder.

      6.3 INDEMNITY PROCEDURE.

      A party or parties hereto agreeing to be responsible for or to indemnify
against any matter pursuant to this Agreement is referred to herein as the
"Indemnifying Party" and the other party or parties claiming indemnity is
referred to as the "Indemnified Party". An Indemnified Party under this
Agreement shall, with respect to claims asserted against such party by any third
party, give written notice to the Indemnifying Party of any liability which
might give rise to a claim for indemnity under this Agreement within sixty (60)
Business Days of the receipt of any written claim from any such third party, but
not later than twenty (20) days prior to the date any answer or responsive
pleading is due, and with respect to other matters for which the Indemnified
Party may seek indemnification, give prompt written notice to the Indemnifying
Party of any liability which might give rise to a claim for indemnity; provided,
however, that any

                                       26
<PAGE>
failure to give such notice will not waive any rights of the Indemnified Party
except to the extent the rights of the Indemnifying Party are materially
prejudiced.

      The Indemnifying Party shall have the right, at its election, to take over
the defense or settlement of such claim by giving written notice to the
Indemnified Party at least fifteen (15) days prior to the time when an answer or
other responsive pleading or notice with respect thereto is required. If the
Indemnifying Party makes such election, it may conduct the defense of such claim
through counsel of its choosing (subject to the Indemnified Party's approval of
such counsel, which approval shall not be unreasonably withheld), shall be
solely responsible for the expenses of such defense and shall be bound by the
results of its defense or settlement of the claim. The Indemnifying Party shall
not settle any such claim without prior notice to and consultation with the
Indemnified Party, and no such settlement involving any equitable relief or
which might have an adverse effect on the Indemnified Party may be agreed to
without the written consent of the Indemnified Party (which consent shall not be
unreasonably withheld). So long as the Indemnifying Party is diligently
contesting any such claim in good faith, the Indemnified Party may pay or settle
such claim only at its own expense and the Indemnifying Party will not be
responsible for the fees of separate legal counsel to the Indemnified Party,
unless the named parties to any proceeding include both parties or
representation of both parties by the same counsel would be inappropriate in the
reasonable opinion of the Indemnified Party, due to conflicts of interest or
otherwise. If the Indemnifying Party does not make such election, or having made
such election does not, in the reasonable opinion of the Indemnified Party
proceed diligently to defend such claim, then the Indemnified Party may (after
written notice to the Indemnifying Party), at the expense of the Indemnifying
Party, elect to take over the defense of and proceed to handle such claim in its
discretion and the Indemnifying Party shall be bound by any defense or
settlement that the Indemnified Party may make in good faith with respect to
such claim, subject to the Indemnifying Party's approval of such defense or
settlement, which approval shall not be unreasonably withheld or delayed. In
connection therewith, the Indemnifying Party will fully cooperate with the
Indemnified Party should the Indemnified Party elect to take over the defense of
any such claim. The parties agree to cooperate in defending such third party
claims and the Indemnified Party shall provide such cooperation and such access
to its books, records and properties as the Indemnifying Party shall reasonably
request with respect to any matter for which indemnification is sought
hereunder; and the parties hereto agree to cooperate with each other in order to
ensure the proper and adequate defense thereof.

      With regard to claims of third parties for which indemnification is
payable hereunder, such indemnification shall be paid by the Indemnifying Party
upon the earlier to occur of: (i) the entry of a judgment against the
Indemnified Party and the expiration of any applicable appeal period, or if
earlier, five (5) days prior to the date that the judgment creditor has the
right to execute the judgment; (ii) the entry of an unappealable judgment or
final appellate decision against the Indemnified Party; or (iii) a settlement of
the claim. Notwithstanding the foregoing, the reasonable expenses of counsel to
the Indemnified Party shall be reimbursed on a current basis by the Indemnifying
Party, to the extent such expenses are required to be paid pursuant to this
Agreement. With regard to other claims for which indemnification is payable
hereunder, such indemnification shall be paid promptly by the Indemnifying Party
upon demand by the Indemnified Party.

                                       27
<PAGE>
                                   ARTICLE VII

                                  MISCELLANEOUS

      7.1 FEES AND EXPENSES.

      The Company shall be responsible for the payment of the Purchasers'
reasonable and documented legal fees and other third-party expenses relating to
the preparation, negotiation and execution of this Agreement and the Transaction
Documents and the consummation of the transactions contemplated herein, not to
exceed $26,500 without the Company's prior approval.

      7.2 ENTIRE AGREEMENT.

      The Transaction Documents, together with the exhibits and schedules
thereto, contain the entire understanding of the parties with respect to the
subject matter hereof and supersede all prior agreements and understandings,
oral or written, with respect to such matters, which the parties acknowledge
have been merged into such documents, exhibits and schedules.

      7.3 NOTICES.

      Any and all notices or other communications or deliveries required or
permitted to be provided hereunder shall be in writing and shall be deemed given
and effective on the earliest of (a) the date of transmission, if such notice or
communication is delivered via facsimile at the facsimile number specified on
Schedule 1 attached hereto prior to 5:00 p.m. (New York City time) on a Trading
Day, (b) the next Trading Day after the date of transmission, if such notice or
communication is delivered via facsimile at the facsimile number on Schedule 1
attached hereto on a day that is not a Trading Day or later than 5:00 p.m. (New
York City time) on any Trading Day, (c) the Trading Day following the date of
mailing, if sent by U.S. nationally recognized overnight courier service, or (d)
upon actual receipt by the party to whom such notice is required to be given.
The address for such notices and communications shall be as follows:

      If to the Purchasers, at each Purchaser's address set forth under its name
on Schedule 1 attached hereto, or with respect to the Company, addressed to:

                  Spectrum Pharmaceuticals, Inc.
                  157 Technology Drive
                  Irvine, California 92618
                  Attention: CEO
                  Facsimile No.: (949) 788-6706

or to such other address or addresses or facsimile number or numbers as any such
party may most recently have designated in writing to the other parties hereto
by such notice. Copies of notices to the Company shall be sent to:

                  Latham & Watkins LLP
                  650 Town Center Drive, Suite 2000
                  Costa Mesa, California 92626

                                       28
<PAGE>
                  Attention: Alan W. Pettis
                  Facsimile No.: (714) 755-8290

Copies of notices to any Purchaser shall be sent to the addresses, if any,
listed on Schedule 1 attached hereto.

      7.4 AMENDMENTS; WAIVERS.

      No provision of this Agreement may be waived or amended except in a
written instrument signed, in the case of an amendment, by the Company and each
Purchaser or, in the case of a waiver, by the party against whom enforcement of
any such waiver is sought. No waiver of any default with respect to any
provision, condition or requirement of this Agreement shall be deemed to be a
continuing waiver in the future or a waiver of any subsequent default or a
waiver of any other provision, condition or requirement hereof, nor shall any
delay or omission of either party to exercise any right hereunder in any manner
impair the exercise of any such right.

      7.5 CONSTRUCTION.

      The headings herein are for convenience only, do not constitute a part of
this Agreement and shall not be deemed to limit or affect any of the provisions
hereof. The language used in this Agreement will be deemed to be the language
chosen by the parties to express their mutual intent, and no rules of strict
construction will be applied against any party. Any form of the word "include"
as used in this Agreement shall be deemed to be followed by the phrase "without
limitation".

      7.6 SUCCESSORS AND ASSIGNS.

      This Agreement shall be binding upon and inure to the benefit of the
parties and their successors and permitted assigns. The Company may not assign
this Agreement or any rights or obligations hereunder without the prior written
consent of each Purchaser. Any Purchaser may assign any or all of its rights
under this Agreement to any Person, provided such transferee agrees in writing
to be bound, with respect to the transferred Securities, by the provisions
hereof that apply to the Purchasers.

      7.7 NO THIRD-PARTY BENEFICIARIES.

      This Agreement is intended for the benefit of the parties hereto and their
respective successors and permitted assigns and is not for the benefit of, nor
may any provision hereof be enforced by, any other Person, except as otherwise
set forth in Article VI.

      7.8 GOVERNING LAW.

      All questions concerning the construction, validity, enforcement and
interpretation of the Transaction Documents shall be governed by and construed
and enforced in accordance with the internal laws of the State of New York,
without regard to the principles of conflicts of law thereof.

                                       29
<PAGE>
      7.9 JURISDICTION; VENUE; SERVICE OF PROCESS.

      This Agreement shall be subject to the exclusive jurisdiction of the
Federal District Court, Southern District of New York and if such court does not
have proper jurisdiction, the State Courts of New York County, New York. The
parties to this Agreement agree that any breach of any term or condition of this
Agreement shall be deemed to be a breach occurring in the State of New York by
virtue of a failure to perform an act required to be performed in the State of
New York and irrevocably and expressly agree to submit to the jurisdiction of
the Federal District Court, Southern District of New York and if such court does
not have proper jurisdiction, the State Courts of New York County, New York for
the purpose of resolving any disputes among the parties relating to this
Agreement or the transactions contemplated hereby. The parties irrevocably
waive, to the fullest extent permitted by law, any objection which they may now
or hereafter have to the laying of venue of any suit, action or proceeding
arising out of or relating to this Agreement, or any judgment entered by any
court in respect hereof brought in New York County, New York, and further
irrevocably waive any claim that any suit, action or proceeding brought in
Federal District Court, Southern District of New York and if such court does not
have proper jurisdiction, the State Courts of New York County, New York has been
brought in an inconvenient forum. Each of the parties hereto consents to process
being served in any such suit, action or proceeding, by mailing a copy thereof
to such party at the address in effect for notices to it under this Agreement
and agrees that such service shall constitute good and sufficient service of
process and notice thereof. Nothing in this Section 7.9 shall affect or limit
any right to serve process in any other manner permitted by law.

      7.10 EXECUTION.

      This Agreement may be executed in two or more counterparts, all of which
when taken together shall be considered one and the same agreement and shall
become effective when counterparts have been signed by each party and delivered
to the other party, it being understood that both parties need not sign the same
counterpart. In the event that any signature is delivered by facsimile or other
electronic image transmission, such signature shall create a valid and binding
obligation of the party executing (or on whose behalf such signature is
executed) with the same force and effect as if such facsimile or electronic
image of the signature page were an original thereof.

      7.11 SEVERABILITY.

      If any provision of this Agreement is held to be invalid or unenforceable
in any respect, the validity and enforceability of the remaining terms and
provisions of this Agreement shall not in any way be affected or impaired
thereby and the parties will attempt to agree upon a valid and enforceable
provision that is a reasonable substitute therefor, and upon so agreeing, shall
incorporate such substitute provision in this Agreement.

      7.12 REPLACEMENT OF SECURITIES.

      If any certificate or instrument evidencing any Shares or Warrant Shares
is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be
issued in exchange and substitution for and upon cancellation thereof, or in
lieu of and substitution therefor, a new

                                       30
<PAGE>
certificate or instrument, but only upon receipt of evidence reasonably
satisfactory to the Company of such loss, theft or destruction and customary and
reasonable indemnity, if requested by the Company.

      7.13 PAYMENT SET ASIDE.

      To the extent that the Company makes a payment or payments to any
Purchaser pursuant to any Transaction Document or a Purchaser enforces or
exercises its rights thereunder, and such payment or payments or the proceeds of
such enforcement or exercise or any part thereof are subsequently invalidated,
declared to be fraudulent or preferential, set aside, recovered from, disgorged
by or are required to be refunded, repaid or otherwise restored to the Company,
a trustee, receiver or any other person under any law (including, without
limitation, any bankruptcy law, state or federal law, common law or equitable
cause of action), then to the extent of any such restoration the obligation or
part thereof originally intended to be satisfied shall, to the extent
permissible under applicable law, be revived and continued in full force and
effect as if such payment had not been made or such enforcement or setoff had
not occurred.

      7.14 INDEPENDENT NATURE OF PURCHASERS' OBLIGATIONS AND RIGHTS.

      The obligations of each Purchaser under any Transaction Document are
several and not joint with the obligations of any other Purchaser, and no
Purchaser shall be responsible in any way for the performance of the obligations
of any other Purchaser under any Transaction Document. Nothing contained herein
or in any Transaction Document, and no action taken by any Purchaser pursuant
thereto, shall be deemed to constitute the Purchasers as a partnership, an
association, a joint venture or any other kind of entity, or create a
presumption that the Purchasers are in any way acting in concert or as a group
with respect to such obligations or the transactions contemplated by the
Transaction Document. Each Purchaser shall be entitled to independently protect
and enforce its rights, including without limitation, the rights arising out of
this Agreement or out of the other Transaction Documents, and it shall not be
necessary for any other Purchaser to be joined as an additional party in any
proceeding for such purpose. Each Purchaser acknowledges that it has been
represented by its own separate legal counsel in their review and negotiation of
the Transaction Documents. For reasons of administrative convenience only,
Purchasers and their respective counsel have chosen to communicate with the
Company through Wiggin and Dana LLP, but each Purchaser acknowledges that such
counsel does not represent any of the Purchasers in this transaction other than
SDS Capital Group, SPC, Ltd.

      7.15 FURTHER ASSURANCES.

      Each party agrees to cooperate fully with the other parties and to execute
such further instruments, documents and agreements and to give such further
written assurances as may be reasonably requested by any other party to better
evidence and reflect the transactions described herein and contemplated hereby
and to carry into effect the intents and purposes of this Agreement, and further
agrees to take promptly, or cause to be taken, all actions, and to do promptly,
or cause to be done, all things necessary, proper or advisable under applicable
law to consummate and make effective the transactions contemplated hereby, to
obtain all necessary waivers, consents and approvals, to effect all necessary
registrations and filings, and to remove any injunctions or other impediments or
delays, legal or otherwise, in order to consummate and

                                       31
<PAGE>
make effective the transactions contemplated by this Agreement for the purpose
of securing to the parties hereto the benefits contemplated by this Agreement.

                            [Signature Page Follows]

                                       32
<PAGE>
      IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the date first above written.

                              COMPANY:

                              SPECTRUM PHARMACEUTICALS, INC.

                              By:  /s/ Rajesh C. Shrotriya
                                   ----------------------------------
                              Name: Rajesh C. Shrotriya, M.D.
                              Title: Chief Executive Officer

                                       33
<PAGE>
                              PURCHASER:

                              Print Exact
                              Name:__________________________________________

                              By:____________________________________________
                              Name:
                              Title:

                              Address:________________________________________

                             _________________________________________________

                             _________________________________________________

                              Telephone:______________________________________

                              Facsimile:_______________________________________

                              Email:__________________________________________

                              SSN/EIN:_______________________________________

                              Amount of

                              Investment:$___________________________

    [Omnibus Spectrum Pharmaceuticals, Inc. Common Stock and Warrant Purchase
                            Agreement Signature Page]

                                       34
<PAGE>
                                   SCHEDULE 1
                                       TO
                            STOCK PURCHASE AGREEMENT
          PURCHASERS AND SHARES OF COMMON STOCK AND WARRANTS PURCHASED

<TABLE>
<CAPTION>
NAME, ADDRESS, FAX NUMBER OF          SHARES OF     COMMON STOCK
PURCHASER AND COPIES OF NOTICES TO:  COMMON STOCK    UNDERLYING      PURCHASE
                                      PURCHASED       WARRANTS         PRICE
                                      ---------       --------         -----
<S>                                  <C>            <C>             <C>
BayStar Capital II LP                   65,000         22,750       $503,750.00
80 E. Sir Francis Drake Blvd.
Suite 2B
Larkspur, CA  94939
Attn: Steven M. Lamar, Managing
Partner

Bristol Investment Fund, Ltd.           83,872         29,355       $650,008.00
c/o Bristol Capital Advisors, LLC
6363 Sunset Blvd., 5th Floor
Hollywood, CA  90028
Attn: Amy Wang, Esq.

Cranshire Capital, L.P.                193,548         67,742      $1,499,997.00
666 Dundee Road, Suite 1901
Northbrook, IL 60062
Attn: Mitchell Kopin, President

C.S.L. Associates L.P.                  40,000         14,000       $310,000.00
399 Park Avenue, 37th Floor
New York, NY  10022
Attn:  Charles S. Lipson, General
Partner

Galleon Captain's Offshore, Ltd.       118,350         41,423       $917,212.50
135 East 57th Street, 16th Floor
New York, NY  10022
Attn: George Lau, Managing
Director

Galleon Captain's Partners, L.P.        31,650         11,078       $245,287.50
135 East 57th Street, 16th Floor
New York, NY  10022
Attn: George Lau, Managing
Director
</TABLE>

                                       35
<PAGE>
<TABLE>
<CAPTION>
NAME, ADDRESS, FAX NUMBER OF          SHARES OF     COMMON STOCK
PURCHASER AND COPIES OF NOTICES TO:  COMMON STOCK    UNDERLYING      PURCHASE
                                      PURCHASED       WARRANTS         PRICE
                                      ---------       --------         -----
<S>                                  <C>            <C>            <C>
Galleon Healthcare Offshore, Ltd.      350,400         122,640     $2,715,600.00
135 East 57th Street, 16th Floor
New York, NY  10022
Attn: George Lau, Managing
Director

Galleon Healthcare Partners, L.P.       49,600         17,360       $384,400.00
135 East 57th Street, 16th Floor
New York, NY  10022
Attn: George Lau, Managing
Director

J.W. Focused Growth Fund, LP            4,516           1,581       $34,999.00
46 Windmill Road
Armonk, NY 10504
Attn: Jason Wild, President

J. Wild Fund, LP                        5,161           1,806       $39,997.75
46 Windmill Road
Armonk, NY 10504
Attn: Jason Wild, President

LEBA Investments, LP                    20,000          7,000       $155,000.00
1645 Village Center Circle, #170
Las Vegas, NV 89134

MAIL ALL DOCUMENTS TO:

c/o Smith Barney
1000 E. Hallandale Beach Blvd.
Hallendale, FL 33009
Attn: Allan Yarkin
Mulligan BioCapital AG                 129,032         45,161       $999,998.00
Stubbenhuk 7
20459 Hamburg, Germany
Attn: Hans Hermann Munchmeyer,
Managing Director

North Sound Legacy Fund LLC             27,500          9,625       $213,125.00
53 Forest Avenue, #202
Old Greenwich, CT 06870
Attn: Thomas E. McAuley, Managing
Member
</TABLE>

                                       36
<PAGE>
<TABLE>
<CAPTION>
NAME, ADDRESS, FAX NUMBER OF          SHARES OF     COMMON STOCK
PURCHASER AND COPIES OF NOTICES TO:  COMMON STOCK    UNDERLYING      PURCHASE
                                      PURCHASED       WARRANTS         PRICE
                                      ---------       --------         -----
<S>                                  <C>            <C>            <C>
North Sound Legacy Institutional       396,000         138,600      $3,069,000
Fund LLC
53 Forest Avenue, #202
Old Greenwich, CT 06870
Attn: Thomas E. McAuley, Managing
Member

North Sound Legacy International       676,500         236,775     $5,242,875.00
LTD
53 Forest Avenue, #202
Old Greenwich, CT 06870
Attn: Thomas E. McAuley, Managing
Member

Off Sands Point, LTD                    62,500         21,875       $484,375.00
280 Park Avenue, 39th Floor
New York, NY 10017
Attn: Stuart Z. Feldman, COO

Omicron Master Trust                   193,548         67,742      $1,499,997.00
810 7th Avenue, 39th Floor
New York, NY 10019
Attn: Bruce Bernstein, Managing
Partner

ProMed Offshore Fund, Ltd.              14,930          5,226       $115,707.50
237 Park Avenue, 9th Floor
New York, NY 10017
Attn: Barry Kurokawa, Managing
Director

ProMed Partners, L.P.                   92,210         32,274       $714,627.50
237 Park Avenue, 9th Floor
New York, NY 10017
Attn: Barry Kurokawa, Managing
Director

ProMed Partners II, L.P.                25,770          9,020       $199,717.50
237 Park Avenue, 9th Floor
New York, NY 10017
Attn: Barry Kurokawa, Managing
Director
</TABLE>

                                       37
<PAGE>
<TABLE>
<CAPTION>
NAME, ADDRESS, FAX NUMBER OF          SHARES OF     COMMON STOCK
PURCHASER AND COPIES OF NOTICES TO:  COMMON STOCK    UNDERLYING      PURCHASE
                                      PURCHASED       WARRANTS         PRICE
                                      ---------       --------         -----
<S>                                  <C>            <C>           <C>
Sands Point Partners, LP                62,500         21,875       $484,375.00
280 Park Avenue, 39th Floor
New York, NY 10017
Attn: Stuart Z. Feldman, COO

Schottenfeld Qualified Associates,      51,612         18,064       $399,993.00
LP
399 Park Avenue, 37th Floor
New York, NY 10022
Attn: Richard Schottenfeld,
Managing Member

SDS Capital Group, SPC, Ltd            200,000         70,000      $1,550,000.00
53 Forest Avenue, Suite 203
Old Greenwich, CT 06870
Attn: Steve Derby, Managing Member

COPIES OF NOTICES TO:
Michael Grundei, Esq.
Wiggin & Dana LLP
400 Atlantic Street
Stamford, CT 06901

Wheaton HealthCare Partners LP          25,806          9,032        $199,996.50
212 Durham Avenue,
Bldg. 1, Suite 201
Metuchen, NJ 08840
Attn: Jerry Treppel

Xmark Fund, LTD.                       146,670         51,335      $1,136,692.50
152 West 57th Street, 21st Floor
New York, NY 10019
Attn: Mitchell D. Kaye, CIO

Xmark Fund, L.P.                       153,330         53,666      $1,188,307.50
152 West 57th Street, 21st Floor
New York, NY 10019
Attn: Mitchell D. Kaye, CIO

TOTALS:                                                           $24,955,038.75
</TABLE>

                                       38

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