Document:

Exhibit 10.3

 

LEASE AMENDMENT AGREEMENT

 

Between

 

FIDIA FARMACEUTICI S.P.A. with registered office in Abano Terme (PD), via

Ponte della Fabbrica 3/A, Italy, V.A.T. No. 00204260285 (hereinafter "Fidia")

 

and

 

FIDIA ADVANCED BIOPOLYMERS S.r.l. with registered office in Abano Terme

(PD), via Ponte della Fabbrica 3/B, Italy, V.A.T. No. 03641500289 (hereinafter "FAB")

 

(hereinafter jointly referred to as the "Parties" and each one as a
"Party")

 

WHEREAS

 

on December 30, 2009, Fidia and FAB entered into a lease agreement (the "Agreement")
related to the lease of certain Property (as defined in the Agreement);

 

 

Fidia and FAB hereby agree as follows:

 

		1)	Definitions included in the Agreement shall have the same meaning in this Lease Amendment Agreement.

 

		2)	With effect as of September 20, 2010, Annex A to the Agreement is replaced by the revised Annex A attached to this Lease Amendment
Agreement.

 

		3)	With effect as of September 20, 2010, Recital (C) to the Agreement is hereby amended as follows:

 

"the Lessor is the owner of the premises located at Abano Terme (PD),
Via Ponte della Fabbrica 3/A and 3/B, registered with the NCT F. 10 mapp. 632 and NCEU F. 10 mapp. 632, as described
by the extract from the Land Registry and maps as per Annex A hereto and identified as follows (the "Property"):

 

		(1)	portion of the building named F2 ("Building F2 – Maps 0008_59 e 0008_02") per mq 380 for warehouse use;

 

		(2)	portion of the building named "Istituto di Ricerca" (LR1 – Maps 0005 e 0006) for mq 1,174 for laboratories
and production facility Tissue Tech and for mq 1,268 for office (ground floor and first floor);".

 

    	-1-

     

    

 

		4)	With effect as of September 20, 2010:

		a)	the table in Section 3.1, is replaced by the following table:

 

	Area	Mq.	
        Monthly rent/mq

        (Euro)
	
        Monthly rent

        (Euro)

	
        Istituto di Ricerca

        (LR1 - Maps 0005 e 006) - Offices

        Warehouse ("Building F2 –Map 0008_59")
	1,268	14.29	18,119
	373	5.11	1,906
	
        Warehouse

        (“Building F2 – Map 0008_02”)
	7	14.29	100
	Istituto di Ricerca (LR1 - Map 0005)- Research Laboratories	655	17.05	11,168
	Istituto di Ricerca (LR1 - Map 006)- Production facility Tissue Tech	519	17.05	8,849
	Amount	2,822	 	41,042

 

And, b) the total amount in line to of Section 31 from September 20, 2010
is Euro 41,042.

 

 

    	-2-

     

    

 

IN WITNESS WHEREOF, the parties have executed or caused this Lease Amendment Agreement
to be executed.

 

Abano Terme, September 20, 2010

 

 

FIDIA FARMACEUTICI S.P.A.

 

By: /s/ Antonio Germani

Antonio Germani, Chief Executive Officer

 

 

FIDIA ADVANCED BIOPOLYMERS S.R.L.

 

By: /s/ Charles H. Sherwood, Ph.D.

Charles Sherwood, President

 

 

 

 

-3-Exhibit 10.4

 

AMENDMENT

TO THE LEASE AGREEMENT (Reg.ne 39 series 3T)

 

By and between

 

FIDIA FARMACEUTICI S.P.A. with legal domicile in Abano Terme
(PD) via Ponte della Fabbrica 3/A, Italy, VAT Code 00204260285 (hereinafter “Fidia”)

 

and

 

ANIKA THERAPEUTICS S.r.l. with legal domicile in Abano Terme
(PD) via Ponte della Fabbrica 3/B, Italy, VAT Code 03641500289 (hereinafter “Anika”)

 

(which shall hereinafter be jointly referred to as the “Parties,”
and individually as a “Party”)

 

WHEREAS

 

on December 30, 2009, Fidia and Anika (formerly FAB S.r.l.) entered
into a lease agreement (the “Agreement”), subsequently amended, in respect of leasing a certain Property (as defined
in the Agreement).

 

Through this Amendment Fidia and Anika establish the following:

 

		1)	The definitions contained in the Agreement shall have the same meanings in this Amendment to the
Lease Agreement.

 

		2)	Effective January 1, 2012, Annex A to the Agreement is replaced by Annex A attached to this Amendment
to the Lease Agreement.

 

		3)	Effective January 1, 2012, recital C) of the Agreement is amended as follows:

 

			“The Lessor is the owner of the leased premises in Abano Terme (PD), via Ponte della Fabbrica
3/A and 3/B, registered in the NCT.F. 10 map 632 and NCEU F. 10 map 632, as described in the registry search and plans as attached
in Annex A hereto and identified as follows (the “Property”)

 

		(1)	a portion of the building called F2 (“Building F2 – plans 0008_59 and 0008_02”),
with 423 m2 to be used as a warehouse;

 

		(2)	a portion of the building called “Research Institute” (LR1 – plans 0005 and 0006),
with 1,174 m2 to be used as laboratories and Tissue Tech production facilities, and 1,268 m2 for office use (ground floor and first
floor);

 

 

    	-1-

     

    

 

		4)	Effective from January 1, 2012 to March 31, 2012:

 

		a)	the table contained in Section 3.1 is replaced by the following table which takes into account
the ISTAT indexation at December 2011:

 

	Area	M2	
        Monthly rent / m2

        (euros)
	
        Monthly rent

        (euros)

	
        Research Institute

        (LR1 – plans 0005 and 0006) – Offices

        Warehouse (“Building F2 – plans 0008_59”)
	1,268	14.63	18,551
	373	5.23	1,951
	
        Warehouse

        (“Building F2 – plans 0008_02”)
	50	14.63	732
	
        Research Institute

        (LR1 – plan 0005) – Research Laboratories
	655	17.46	11,436
	
        Research Institute

        (LR1 – plan 0006) – Tissue Tech Production Facilities
	519	17.46	9,062
	Totals	2,865	 	41,732

 

and b) the total amount of
the monthly rent in line with the provisions of Section 3.1, effective from January 1, 2012 to 03.31.2012, is 41,732 euros.

 

    	-2-

     

    

 

		5)	Effective April 1, 2012, the premises leased to Anika are reduced and therefore the spaces being
leased are the ones indicated in Annex B of this Amendment to the Lease Agreement.

 

		6)	Effective from April 1, 2012, recital C) of the Agreement is amended as follows:

 

			“The Lessor is the owner of the leased premises in Abano Terme (PD), via Ponte della Fabbrica
3/A and 3/B, registered in the NCT.F. 10 map 632 and NCEU F. 10 map 632, as described in the registry search and plans as attached
in Annex A hereto and identified as follows (the “Property”)

 

		(3)	a portion of the building called F2 (“Building F2 – plans 0008_59 and 0008_02”),
with 423 m2 to be used as a warehouse;

 

		(4)	a portion of the building called “Research Institute” (LR1 – plans 0005 and 0006),
with 1,054 m2 to be used as laboratories and Tissue Tech production facilities, and 1,125 m2 for office use (ground floor and first
floor);

 

		7)	Effective from April 1, 2012, the table contained in Section 3.1 is replaced by the following table:

 

	Area	M2	
        Monthly rent / m2

        (euros)
	
        Monthly rent

        (euros)

	
        Research Institute

        (LR1 – plans 0005 and 0006) – Offices

        Warehouse (“Building F2 – plans 0008_59”)
	1,125	14.63	16,459
	373	5.23	1,951
	
        Warehouse

        (“Building F2 – plans 0008_02”)
	50	14.63	732
	
        Research Institute

        (LR1 – plan
	535	17.46	9,341

 

    	-3-

     

    

 

	0005) – Research Laboratories	 	 	 
	
        Research Institute

        (LR1 – plan 0006) – Tissue Tech Production Facilities
	519	17.46	9,062
	Totals	2,602	 	37,545

 

 

			Therefore, the total amount of the monthly rent in line with the provisions of Section 3.1 effective
from April 1, 2012, is 37,545 euros.

 

		8)	With the return of the R&D spaces, Anika shall reimburse Fidia the sum of €24,666.00 pursuant
to Art. 4 of the Lease Agreement of June 18, 2010.

 

		9)	The other provisions of the agreement remain unchanged.

 

    	-4-

     

    

IN WITNESS WHEREOF, the Parties have signed this Amendment to the
Lease Agreement on

 

Abano Terme, April 16, 2012

 

 

FIDIA FARMACEUTICI S.P.A.

 

By: /s/ Antonio Germani

Antonio Germani, Managing Director

 

ANIKA THERAPEUTICS S.r.l.

 

By: /s/ Charles H. Sherwood, Ph.D.

Charles Sherwood, President

 

 

 

 

-5-Exhibit 10.5

 

AMENDMENT

TO THE LEASE AGREEMENT (Reg. 39 series 3T)

 

Between

 

FIDIA FARMACEUTICI S.P.A. with headquarters in Abano Terme (PD), via Ponte della
Fabbrica 3/A, Italy, VAT No. 00204260285 (hereinafter “Fidia”)

 

and

 

ANIKA THERAPEUTICS S.r.l. with headquarters in Abano Terme (PD), via Ponte della
Fabbrica 3/B, Italy, VAT No. 03641500289 (hereinafter “Anika”)

 

(hereinafter jointly referred to as the “Parties” and singularly referred
to as a “Party”)

 

WHEREAS

 

On December 30, 2009, Fidia and Anika (formerly FAB S.r.l.) entered into a lease agreement
(the “Agreement”), subsequently amended, regarding the lease of a certain Property (as defined in the Agreement)

 

In this Amendment, Fidia and Anika establish the following:

 

		1)	The definitions contained in the Agreement shall have the same meaning in this Amendment to the Lease Agreement.

 

		2)	Effective January 1, 2016, the locations leased to Anika are those indicated in Attachment B to this Amendment to the Lease
Agreement, i.e.:

 

		(1)	portion of the building called F2 (“Building F2 – plans 0008_59 and 0008_02”) with 155 m2 for
warehouse use and 80 m2 for cold storage;

 

		(2)	portion of the building called “Research Institute” (LR1 – plans 0005 and 0006) with 535 m2 for
laboratory use and 1,125 m2 for office use (ground floor and first floor);

 

		3)	As of January 1, 2016, the table included in Section 3.1 shall be replaced by the following table:

 

 

    	-1-

     

    

 

	Area	m2	
        Monthly rent/m2

         

        (Euro)
	
        Monthly rent

         

        (Euro)

         

	
        Research Institute (LR1 – plans 0005 and 006 [sic])
        – Offices

         

        Warehouse (“Building F2 – plan 0008_59”)

         
	1,125	14.96	16,830.00
	155	5.34	827.70
	
        Warehouse

         

        (“Building F2 – plan 0008_02”)
	80	14.96	1,196.80
	
        Research Institute

        (LR1 – plan 0005) – Research Laboratories
	535	17.86	9,555.10
	Totals	1,895	 	28,409.60

 

Therefore, the total amount of rent/month in accordance with the provisions of Section
3.1 beginning on January 1, 2016, is 28,409.60 euros.

 

		4)	The other provisions of the Agreement remain unchanged.

 

IN WITNESS WHEREOF, the Parties have signed this Amendment to the Lease Agreement on

 

Abano Terme, February 26, 2016

 

 

FIDIA FARMACEUTICI S.P.A.ANIKA THERAPEUTICS S.r.l.

 

	By: 	/s/ Giorgio Foresti	 	By:
     	/s/ Charles H. Sherwood
	 	Giorgio Foresti, Chief Executive Officer	 	 	Charles Sherwood, President
	 	 	 	 	 

 

 

 

 

-2-

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