Document:

Exhibit 10.7

 

CONFIDENTIAL TREATMENT REQUESTED UNDER RULE 406 UNDER THE
SECURITIES ACT OF 1933, AS AMENDED.

 

[*] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL
TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 

UNANIMOUS SHAREHOLDERS AGREEMENT

 

This Agreement dated as of the 27th day
of March, 2014.

 

AMONG:

 

ADVANCED ACCELERATOR APPLICATIONS
CANADA INC., a corporation incorporated under the laws of Canada

 

(Hereinafter called “AAA Holdco")

 

OF THE FIRST PART;

 

- and-

 

4549694 CANADA INC., a corporation
incorporated under the laws of Canada

 

(Hereinafter called “Exchangeco")

 

OF THE SECOND PART;

 

- and-

 

7329563 CANADA INC., a corporation
incorporated under the laws of Canada

 

(Hereinafter called “Atreus Holdco")

 

OF THE THIRD PART;

 

- and-

 

ATREUS PHARMACEUTICALS
CORPORATION, a Corporation incorporated under the laws of Canada

 

(Hereinafter called the "Corporation")

 

OF THE FOURTH PART.

 

    	 

    	 

    

  

WHEREAS:

 

		1.	The authorized capital of the Corporation consists of an unlimited number of common shares, of
which 1,000 common shares are issued and outstanding and held by the shareholders set out in Schedule A hereto;

 

		2.	The parties wish to enter into this Agreement to provide for the conduct of the business and affairs
of the Corporation, to provide for restrictions on the transfer and ownership of their shares of the Corporation and to govern
their relationship as shareholders of the Corporation.

 

NOW THEREFORE THIS
AGREEMENT WITNESSES THAT, in consideration of the mutual covenants and agreement herein contained and other good and valuable
consideration, the parties hereto agree as follows:

 

ARTICLE 1

 

INTERPRETATION

 

		1.1	Definitions

 

Unless the subject matter or context otherwise
requires:

 

		(a)	"Act" means the Canada Business Corporations Act and any statute that may be substituted therefore, as from
time to time amended, and the regulations thereto and any regulations that may be substituted therefore, as from time to time amended;

 

		(b)	"Affiliate" has the meaning assigned to such term in the Act;

 

		(c)	"thisAgreement"the"Agreement","hereto","hereof',"herein","hereby","hereunder"
and similar expressions mean or refer to this Agreement as amended , from time to time, any indenture, agreement or instrument
supplemental or ancillary hereto or in the implementation hereof, and the expressions "Section", "subsection"
and "paragraph" followed by a number or letter refer to the specified section, subsection or paragraph of
this Agreement;

 

		(d)	"Annual Budget" means the detailed financial
and cash budget of the projected businessactivities and operations of the Corporation, including estimates of proposed and
committed operating and capital expenditures and the subject matter of each expenditure and all sources of revenue, cash
and financing of the Corporation for the subject period;

 

    	~ 2 ~

    	 

    

  

		(e)	"Articles” means the articles of incorporation
                                         of the Corporation, as amended from time to time;

 

		(f)	"Board of Directors” means the board of directors of the Corporation which shall be constituted in accordance
with the provisions of subsection 2.2 hereof

 

		(g)	"Business Day" means any day other than a Saturday, Sunday or statutory holiday in the Province of Ontario
or France;

 

		(h)	"Common Shares" means the common shares in the capital of the Corporation and any other shares that may henceforth
be issued having the same rights, privileges and restrictions as such common shares;

 

		(i)	"Control” has the meaning assigned to such term
                                         in the Act;

 

		(j)	"Fiscal Year" means the fiscal year of the Corporation which ends on December31 in each year;

 

		(k)	"Milestone" means the Corporation obtaining the IND by the FDA to proceed with a clinical trial with Tc-Annexin,
for the indication on Rheumatoid Arthritis;

 

		(1)	"Person" means any individual, company, corporation, partnership, firm, trust, sole proprietorship, government
or entity howsoever designated or constituted;

 

		(m)	"Public Offering" means an underwritten
public offering of its Common Shares pursuant to a registration statement that has been declared effective under the UnitedStates
Securities Act of 1933 or a prospectus filed under applicable Canadian securities laws in respect of which a (final) receipt has
been obtained, accompanied by the listing of the Common Shares on the Toronto Stock Exchange and/or the Nasdaq National Market
and/or the New York Stock Exchange and/or any other stock exchange or market approved by Special Shareholder Approval;

 

		(n	"Share" means any share in the capital of the Corporation;

 

		(0)	"Shareholder” means any party to this Agreement who is a holder of Shares; and

 

		(p)	"Special Shareholder Approval" means the approval of the holders of Shares representing not less than sixty-six
and two-thirds percent (66 2/3%) of the votes attaching to the outstanding shares in the Corporation.

 

		1.2	Schedules

 

The following are the
schedules attached to and forming part of this Agreement

 

 Schedule A - Shareholders
and Issued Capital of the Corporation

 

    	~ 3 ~

    	 

    

 

		1.3	Extended Meanings

 

Words importing the singular
number include the plural and vice versa and words importing the masculine gender include the feminine and neuter genders and vice
versa.

 

		1.4	Interpretation Not Affected by Headings

 

The division of this Agreement
into sections and insertion of headings are for convenience of reference only and shall not affect the construction or Interpretation
of this Agreement.

 

		1.5	Applicable Law

 

This Agreement shall be interpreted
in accordance with and be governed by the laws of Ontario and the laws of Canada applicable therein.

 

		1.6	Entire Agreement

 

This Agreement constitutes the
entire agreement among the parties with respect to the subject matter hereof and contains all the representations, undertakings
and agreements of the respective parties.

 

		1.7	Funds

 

All dollar amounts referred to in this Agreement are
in the lawful money of the United States of America.

 

		1.8	Paramountcy

 

If any provision of this Agreement
conflicts with the Articles or by-laws of the Corporation or any agreement among the Corporation and/or any of the Shareholders
and/or any officers or directors of the Corporation concerning matters which are the subject matter of this Agreement, the provisions
of this Agreement shall prevail.

 

		1.9	Invalidity

 

If any provision of this Agreement
shall be held invalid or unenforceable in any jurisdiction, such invalidity or unenforceability shall attach only to such provision
such jurisdiction and shall not in any manner affect or render invalid or unenforceable such provision 111 any other jurisdiction
or any other provision of this Agreement in any jurisdiction.

 

		1.10	Calculation of Time

 

Where in this Agreement a period
of time is given for the doing of any act following the giving of a notice the date on which the notice is given shall be excluded
from the calculation of the time period. When any period of time for the performance of any act expires on a Saturday, Sunday or
a national statutory holiday the period shall be deemed to expire on the next following Business Day. Notwithstanding anything
herein contained to the contrary, the Corporation shall have the right, at its sole option, to postpone any date provided for herein
to a date not exceeding three Business days after such date.

 

    	~ 4 ~

    	 

    

  

		1.11	Privity

 

This Agreement shall be binding
upon all Persons executing these presents, and all Persons who subsequently become holders of Shares, each of whom shall execute
a counterpart of this Agreement. Any agreement to be bound hereby and any other agreement among the parties hereto with respect
to the Corporation or the Shares may be effectively delivered by one party to each of the others by delivery of an executed counterpart
of this Agreement to the Corporation.

 

ARTICLE 2

 

CONDUCT OF THE AFFAIRS OF THE CORPORATION

 

		2.1	Business and Affairs of the Company

 

The Shareholders shall cause
such meeting to be held, votes to be cast, resolutions to be passed, by-laws to be made and confirmed, documents to be executed
and all other things and acts to be done to ensure that, at all times, the following provisions are in effect or are complied with,
or with respect to any provision which is not entirely within the control or power of the Shareholders to cause compliance therewith,
the Shareholders .shall use their best efforts to cause such compliance to occur.

 

		2.2	Directors of the Corporation

 

(a)     The
Shareholders, by majority vote, will determine from time to time the number of directors to be elected.

 

(b)    The
Shareholders will from time to time so act and vote (to the extent that each is able to do so on account of its respective shareholdings
or otherwise) so that the board of directors (the "Board") of the Corporation shall consist of at least one nominee of
AAA Holdco and at least one nominee of Atreus Holdco; provided that, such right shall terminate in respect of each such Shareholder
if AAA Holdco and Exchangeco, on the one hand, or Atreus Holdco, on the other hand, shall cease to hold Shares in the capital of
the Corporation representing at least 5% of the votes attaching to the outstanding shares in the Corporation.

 

(c)    Each
of AAA Holdco and Atreus Holdco shall be entitled at any time to require the removal of any director nominated by it and to provide
for a successor nominee by written notice to the Corporation and to the other Shareholders. No Shareholder other than a shareholder
having nomination rights shall use its voting rights to remove a director who is a nominee of AAA Holdco or Atreus Holdco. If a
director nominated by AAA Holdco or Atreus Holdco ceases to be a director for any reason, the Shareholders shall, if necessary,
fill the

 

    	~ 5 ~

    	 

    

  

vacancy thereby created by appointing,
as soon as reasonably possible, the individual who is nominated by AAA Holdco or Atreus Holdco, as the case may be.

 

(d)     A
quorum for a meeting of directors of the Corporation shall be a nominee of each of the Shareholders; provided that, if a nominee
is not able to attend two (2) successive properly called board meetings, then the next meetings may proceed without such nominee
being present, so long as a majority of directors are present.

 

(e)    Notice
of meetings of the Board shall be accompanied by an agenda together with copies of documents to be considered at such meetings.
AAA Holdco and Atreus Holdco shall make best efforts to convene board meetings at least [quarterly] during the year. Each of AAA
Holdco and Atreus Holdco may bring one observer to board meetings, but such observer shall have no right to vote. Any additional
observers shall require the approval of the other board members.

 

(f)    The
Board shall appoint a Chairperson (who shall not have a casting vote in the event of an equality of votes on any matter among members
of the Board), who shall initially be ■.

 

		2.3	Directors' Compensation and Indemnity

 

The Corporation will pay all
reasonable out-of pocket expenses incurred by the directors to attend meetings of the Board of Directors. Directors shall be indemnified
by the Corporation with respect to their actions as directors to the maximum extent, and subject to the limitations, permitted
by law. The Board will determine what, if any, compensation will be paid to any external director

 

		2.4	Shareholders' Right of Inspection and Inquiry

 

The Corporation shall permit
Persons designated by the Shareholders to visit and inspect any properties of the Corporation, to examine the books and financial
records of the Corporation and to discuss with management its affairs, finances and accounts all during normal business hours and
as often as may be reasonably requested, with prior notice and at times reasonably convenient to management. The Persons designated
pursuant to this provision may include accountants (including the auditors of the Corporation) or management consultants or
others appointed to examine all or any aspect of the operations of the Corporation, and the Corporation agrees to cause management
to answer fully and fairly and to the best of their ability any reasonable inquiries which such Persons may have. The Corporation
agrees that such Persons may, in the course of their investigations, discuss the business and affairs of the Corporation with the
officers and directors and with the auditors of the Corporation.

 

		2.5	Annual Financial Statements

 

Within 90 days after the end
of the Fiscal Year, the Corporation shall prepare and furnish or cause to be prepared and furnished to the Shareholders unaudited
consolidated financial statements in respect of the Corporation, including a balance sheet and statements of changes in financial
position and profit and loss, together with a comparison of the actual

 

    	~ 6 ~

    	 

    

 

budgeted results, each of the end of such Fiscal Year and
prepared in accordance with Canadian generally accepted accounting principles applied on a consistent basis from time to time and
certified by the President of the Corporation. The Shareholders agree to waive the right to receive audited financial statements
as permitted in the Act; provided however, that a Shareholder may retract such waiver in respect of a fiscal year of the Corporation
and prior to the commencement of such fiscal year if (i) such Shareholder agrees to pay the full incremental costs of conducting
such audit; and (ii) such audit can be completed without unduly interfering with the business operations of the Corporation.

 

		2.6	Additional Financial Reporting

 

The Corporation shall provide
the Shareholders with the following data:

 

(a)     Quarterly
financial report, within 30 days of the end of each calendar quarter;

 

(b)     6
months balance sheet, income statement and cash flow statement for the Corporation, its Subsidiaries and on a consolidated basis,
within 40 days after the end of each semester; and

 

(c)     budget
for the year including income statement balance sheet and cash flow statements and capital expenditure plans of the Corporation,
its subsidiaries and on a consolidated basis, within thirty (30) days of the end of each fiscal year of the Corporation.

 

		2.7	Board of Directors Consent/Special Shareholder
Approval Respecting Certain Matters

 

Save and except as expressly
provided in this Agreement, no action shall be taken by the Corporation in respect of any of the matters described below without
prior Special Shareholder Approval, which approval shall be in addition to any other approvals that may be required by the
Act;

 

(a)     the
approval of the Corporation's annual budget;

 

(b)     any
significant deviation from the Corporation's current business plan;

 

(c)     any
redemption or repurchase of Shares not effected on a pro-rata basis.

 

		2.8	Licensing of IP Almexin rights in the USA and Japan

 

Any decisions with respect to
the licensing of IP Annexin rights in the USA and Japan shall be on terms determined by Atreus Holdco; provided that:

 

(i)     Atreus
Holdco shall consult with AAA Holdco prior to any such agreement being entered into;

 

(ii)     Atreus
Holdco shall provide an execution copy of the proposed license agreement to AAA Holdco not less than fifteen (15) days prior to
the execution of any such agreement, during which time AAA Holdco shall have the right to provide a written opinion thereon which
shall be considered in good faith by Atreus Holdco; and

 

    	~ 7 ~

    	 

    

  

(iii)     The
terms of such license agreement shall be commercially reasonable and consistent with the fiduciary obligations of the directors
of the Corporation.

 

ARTICLE 3

 

RESTRICTIONS ON TRANSFER OF SHARES

 

		3.1	Restrictions on Transfer of Shares

 

No Shareholder shall, except
as expressly provided herein, directly or indirectly, sell assign or otherwise transfer or encumber by pledge, assignment, mortgage,
charge or otherwise, any Shares from time to time held by it. Any attempted sale, assignment, transfer or other disposition of
Shares in violation of this Agreement shall be void and of no force and effect and the Corporation shall not recognize any such
attempted disposition.

 

A transfer of a controlling interest
in AAA Holdco or Atreus Holdco shall be subject to the provisions of this Article 3.

 

		3.2	Pledge of Shares

 

Each of the Shareholders may
mortgage, hypothecate, pledge or charge its Shares to a commercial lending institution as security for an operating or term loan
provided by that institution to the Corporation, provided that each of the Shareholders consents in advance to such transaction
and provided further that the Person to whom such Shares are mortgage, hypothecated, pledge or charged agrees in writing to be
bound by the provision of this Agreement with respect to such Shares and, in the event of the realization on such Shares, such
Person shall become a party to this Agreement.

 

		3.3	Permitted Transfers

 

Notwithstanding the terms of
this Agreement, a Shareholder shall be entitled to sell, assign, transfer or otherwise dispose of all or any shares in the capital
of the Corporation beneficially owned by such Shareholder to an Affiliate, provided that, prior to the completion of such sale,
assignment, transfer or other disposition, the transferee agrees to be bound by the terms of this Agreement.

 

		3.4	Piggyback/ Drag-Along

 

		(a)	Offer - If an independent third party (the "Third
Party") shall make a bona fide offer (the "Offer") to purchase all or a majority of the Shares of the
Corporation which the holders of not less than sixty-six and two-thirds (66 2/3rds) of the Shares (the "Super Majority")
wish to accept, then, the Super Majority shall give notice (the "Notice of Sale") to the other Shareholders (the
"Other Shareholder(s)") specifying therein the number of Shares which Super Majority desires to sell (the "Offered
Shares") and the terms upon which and the price at which it desires to sell the Offered Shares, including the identity
of the proposed purchaser (the "Selling Price").

 

    	~ 8 ~

    	 

    

  

		(b)	Rejection, Third Party Sale and Piggyback - The Super Majority may, at any time and from
time to time during the period of 90 days next following the delivery of the Notice of Sale, sell the Offered Shares to the Third
Party at a price which is not less than the Selling Price and on terms not less favourable to the Super Majority than those set
out in the Notice of Sale, provided that the Third Party shall have offered by notice given to each of the Other Shareholders to
purchase from each of the Other Shareholders all the Shares owned by such of the Other Shareholders at the price and upon the terms
and conditions set forth in the offer from the Third Party.

 

		(c)	Time for Sale - If the Super Majority does not effect a sale to the Third Party during the
90-day period referred to in paragraph (b), then the foregoing provisions hereof shall again apply thereto and so on from time
to time.

 

		(d)	Drag-Along - In the event that any of the Other Shareholders do not wish to accept the Third
Party offer under paragraph (b) above, the Super Majority may, if the Third Party Offer is an offer to acquire all of the Shares,
by notice in writing given to the Other Shareholders who do not wish to sell at any time ten (l0) days or more prior to the expiry
of the Offer, require the Other Shareholders to sell their Shares pursuant to the Offer at the same price specified in the Offer:

 

Notwithstanding the foregoing,
no Shareholder is required to comply with the terms of this Section 3.4 if:

 

		(i)	consideration under the Offer is not payable in cash or securities of a publicly traded entity
(or shares exchangeable into shares of a publicly traded entity);

 

		(ii)	the liability of such Shareholder under the purchase agreement in respect of the Offer (including,
without limitation, liability for a breach of representation or warranty or for a claim under an indemnity) exceeds with respect
to such Shareholder the lesser of such Shareholder's (A.) pro rata share of any claim; and (B,) the purchase price payable to such
Investor; or

 

		(iii)	any representation and warranty to be given by a Shareholder is to be given on a joint and several
basis.

 

		(e)	Power of Attorney - Each of the Other Shareholders hereby appoints, in the event that circumstances
give rise to this Section 3.4, the President of the Corporation as the Shareholder's attorney, with full power of substitution,
in the name of the Shareholder, to execute and deliver all deeds, transfers, assignments and assurances necessary to effectively
transfer the interest being sold in the Corporation under this Section 3.4.Such appointment, being coupled with an interest, is
irrevocable by each 

 

    	~ 9 ~

    	 

    

  

Shareholder and shall not
be revoked by the insolvency, bankruptcy, death incapacity, dissolution, liquidation or other termination of the existence of the
Shareholder and the Shareholder agrees to ratify and confirm all that the Corporation may do or cause to be done pursuant to the
foregoing. The Shareholder consents to any transfer of shares made pursuant to the foregoing.

 

		3.5	Right of First Refusal

 

		(a)	Unless the provisions of Section 3.4(d) apply, in the
event that any Shareholder (hereinafter in this Section 3.5 referred to as the "Selling Shareholder") receives
a bona fide offer from a person, firm or corporation dealing at arm's length with such Shareholder (including another Shareholder)
(hereinafter in this Section 3 referred to as the "Offer") to purchase any or all of the Shares owned or
controlled by the Selling Shareholder, which the Selling Shareholder is prepared to accept, then the Selling Shareholder shall
forthwith give to the Corporation and to each of the other Shareholders who owns more than one percent (1%) of the outstanding
Common Shares (hereinafter in this Section 3.5 referred to as the "Offeree Shareholders") notice in writing of
its desire or intention to sell such Shares accompanied by a copy of the entire Offer which, without limiting the generality of
the foregoing, shall fully identify the offeror.

 

		(b)	Such notice shall provide that the Corporation shall
be entitled to purchase any or all of the offered Shares and each Offeree Shareholder shall be entitled to purchase such number
of the offered Shares not purchased by the Corporation as nearly as may be in proportion to the number of Shares of the class
of offered Shares held by it at the date of the Offer on the same terms as specified in the Offer and shall also state that any
Offeree Shareholder who desires to purchase a number of Shares so offered in excess of its proportion shall in its reply state
how many Shares in excess of its proportion it desires to purchase. Such notice shall also provide that if the Corporation or
Offeree Shareholder do not accept such offer from the Selling Shareholder within thirty (30) days after the date of notice of
the Offer, it will be deemed to have been declined. The Corporation shall notify the Selling Shareholder and each Offeree Shareholder
within fifteen (15) days of receipt of notice of the Offer whether it intends to purchase any of the Shares.

 

		(c)	If all the Offeree Shareholders do not claim their respective proportions, the unclaimed Shares
so offered shall be used for satisfying the claims of Offeree Shareholders for Shares in excess of their proportions and if the
claims in excess are more than sufficient to exhaust such unclaimed Shares, the unclaimed Shares shall be divided pro rata among
the Offeree Shareholders desiring excess Shares in proportion to their existing holdings of Shares of the class of offered Shares;
provided that no Offeree Shareholder shall be bound to take any Shares in excess of the amount which it desires.

 

		(d)	If any Shares shall not be capable of being offered to or divided among the Offeree Shareholders
in proportion to their existing holdings of Shares without

 

    	~ 10 ~

    	 

    

  

division into fractions of shares,
the same shall be offered to or divided among the Offeree Shareholders as nearly as may be in proportion to the number of Shares
of the class of offered Shares held by them respectively at the date of such Offer as may be determined by the Board.

 

		(e)	If by the time limited by the Offer, the Corporation
and the Offeree Shareholders have not agreed to purchase all the Shares offered thereby on the terms specified in the Offer, the
Selling Shareholder shall be under no obligation to sell any Shares to the Corporation and the Offeree Shareholders or any of
them and the Selling Shareholder may, within ninety (90) days from the date of the Offer, sell all and not less than all of the
Shares specified in the Offer pursuant to the provisions of this Section 3.5 to the bona fide purchaser at a price not less than
the share price set out in the Offer and on the other terms and conditions set out in the Offer; provided that such person or
persons to whom the Selling Shareholder sells the Shares, contemporaneously with the purchase of such Shares, shall covenant and
agree with all the other Shareholders to be bound by the terms and conditions of this Agreement as if it were an original party
thereto by signing an acknowledgment to become bound by the terms of this Agreement. After the expiration of the said ninety
(90) days, no sale of Shares shall be made except without again complying with the provisions of this Section 3.5.

 

ARTICLE 4

 

ADDITIONAL ISSUE OF SHARES

 

		4.1	Pre-Emptive Right

 

Subject to the provisions of
Section 4.2 hereof, in the event the Corporation wishes at any time to issue any Shares (except for the granting of options to
employees not to exceed 10% of the issued and outstanding shares of the Corporation) it shall offer them for purchase by the Shareholders
by notice given to each Shareholder. Such notice shall be given within 10 days of the approval of the Board of Directors of a proposal
to issue Shares to raise funds and shall set forth a description of the Shares to be offered, the purchase price and the purchase
date which shall be a date not earlier than twenty (20) days after the date of such notice. Upon receipt of such notice, each such
Shareholder shall have the right to subscribe for and purchase a number of such Shares determined by multiplying the total
number of Share offered by a fraction, the numerator of which shall be the number of Common Shares owned by such Shareholder at
the date of such notice and the denominator of which shall be the total number of Conunon Shares outstanding as at the date of
such notice. Such right shall be exercised by the Shareholder by giving notice of acceptance to the Corporation within twenty (20)
days after the receipt of the notice from the Corporation. In the event that the Shareholder does exercise such right it shall
subscribe, purchase and pay for such Shares on the purchase date set forth in the notice of the Corporation. If all the Shareholders
do not subscribe for their respective proportions, the unsubscribed Shares shall be used to satisfy the subscriptions of such Shareholders
for Shares in excess of their proportion and,

 

    	~ 11 ~

    	 

    

 

if the subscriptions in excess are more than sufficient to exhaust such unsubscribed
Shares, the unsubscribed Shares shall be divided pro rata among the Shareholders desiring Shares as nearly as may be in proportion
to the number of Common Shares held by them respectively at the date of such notice, but no Shareholder shall be bound to take
any such Shares in excess of the amount it desires. It shall be a condition to the issuance of any new shares that the new Shareholder
become party to this Agreement or, if agreed by the Board, another shareholder or share restriction agreement approved by the Board.

 

    	~ 12 ~

    	 

    

  

		4.2	Right of AAA Holdco to Increase Shareholdings

 

Notwithstanding the provisions
of Section 4,1 hereof, and provided AAA Holdco and Exchangeco together own more than 50% of the Shares in Atreus and have no obligation
to return Shares to the Corporation that would leave it with less than 50% of the Shares, AAA Holdco shall have the right, exercisable
by a written offer to the Corporation, with a copy to Atreus Holdco, any time after the day which is eighteen (18) months after
the date of this Agreement, to subscribe for such number of additional Common Shares to permit it to reach up to a 65% shareholding
in the Corporation, at a price per share determined in AAA Holdco's sole discretion (the "AAA Holdco Offer").
In case such an offer is made in writing to the Corporation, the Corporation, and Atreus Holdco, shall have the right to find investors
to subscribe to substantially the same amount of shares that are the subject matter of the AAA Holdco Offer at a price [*] higher
than the price offered by AAA Holdco (the "Higher Price"), within [*] months from receipt by the Corporation of
the AAA Holdco Offer. Atreus Holdco shall be permitted to disclose relevant information about the Corporation to prospective investors
considering making an investment in the Corporation based on the AAA Holdco Offer, subject to the execution of a confidentiality
and non-disclosure agreement in a form approved by AAA Holdco.

 

In case one or more investors
place a bona fide binding offer at a Higher Price as set out above within the above mentioned [*] months period, then the investors'
offer will be deemed accepted and the offering investor shall have the obligation to subscribe to the offered shares at a Higher
Price and AAA Holdco shall have the right, but not the obligation, to subscribe to the same amount of shares that are the subject
matter of the AAA Holdco Offer, at the Higher Price. In any case, AAA Holdco shall have the right to subscribe for additional shares
at the Higher Price in order to maintain majority.

 

In case the Corporation and Atreus
Holdco do not find other investors within the above mentioned [*] months period, then AAA Holdco shall have the right to complete
the AAA Holdco Offer within [*] ([*]) days after the expiry of such [*] month period, and the Corporation shall fully cooperate
in order to complete such transaction.

 

ARTICLE 5

 

PAYMENT AND CLOSING PROVISIONS

 

		5.1	Payment and Closing Provisions

 

In the event of the sale of Shares
as provided in Article 3 hereof, the party selling shall in this subsection 5.1 be called the "Vendor" and the
party purchasing shall be in this subsection 5.1 be called the "Purchaser" and the following provisions shall apply:

 

Certain confidential information has been omitted from this
document, as indicated by the notation “[*]”. The omitted information has been filed on a confidential basis with the
Securities and Exchange Commission pursuant to a request for confidential treatment.

 

    	~ 13 ~

    	 

    

 

(a)     Payment
of Purchase Price and Delivery of Certificates - The purchase price shall be paid in such a manner as the Vendor and the Purchaser
may agree or as specified pursuant to the relevant provision of this Agreement, as the case may be, against receipt by the Purchaser
of the share certificate or certificates representing the Shares being purchased and sold, duly endorsed in blank for transfer
together with signed and dated resignations by the Vendor or its nominee as a director and officer of the Corporation.

 

(b)     Closing
- closing shall take place at 10:00 a.m. on the closing date at the office of the solicitors for the Corporation.

 

(c)     Title
- The Vendor shall warrant that it has good and marketable title to the Shares being sold subject only to the terms of this Agreement,
and shall deliver to the Purchaser all such documents, instruments and releases and shall take all such steps and do all such acts
and things as may be necessary or desirable to vest title in the Shares to the Purchaser and the Purchaser shall be bound by all
the terms of this Agreement as if he had been a party hereto.

 

(d)     Failure
to Complete Sale - If on the date of closing the Vendor shall have failed, neglected or refused to complete the sale, the
Purchaser shall have the right to deposit the purchase price for the account of the Vendor in the Corporation's bank and thereafter
to execute and deliver such deeds, transfers of share certificates, resignations, releases and other documents that may be necessary
or desirable in order to complete the transaction with respect to such purchase; and the Purchaser is hereby irrevocably constituted
and appointed as the attorney of the Vendor to so execute and deliver.

 

(e)     Vendor
Indebted to Corporation - If at the time of such sale the Vendor shall be indebted to the Corporation, the Purchaser shall
at the Vendor's option pay, satisfy and discharge suchindebtedness out of the purchase price payable for the Shares.

 

(f)     Assignment
of Indebtedness - If at the time of sale the Corporation shall be indebted to the Vendor, the Purchaser shall, at the Vendor's
option, upon the closing of such sale, purchase from the Vendor that proportion of the indebtedness that the number of Shares to
be sold bears to the total number of Shares held by the Vendor for a price equal to the amount thereof and shall pay such price
to the Vendor on closing by certified cheque against the delivery of a valid assignment to the Purchaser of such indebtedness.
Alternatively, if the Purchaser and the non-selling Shareholders if any agree, the Purchaser may cause the Corporation to repay
such indebtedness or portion thereof to the Vendor.

 

(g)     Liability
as Guarantor  - If at the time of sale, the Vendor shall be liable or responsible as a guarantor for any debts, liabilities
or obligations of the Corporation, the Purchaser shall use its best efforts to cause any and all such guarantees to be released
on or before the date of closing and, in the event that the Purchaser shall be unable to deliver up such guarantees, the Purchaser
shall indemnify and save harmless the Vendor from all claims arising out of such guarantees.

 

    	~ 14 ~

    	 

    

  

(h)    Payment
of Declared Dividends - Prior to the closing of any sale of Shares any declared and unpaid dividends in respect of the Shares
to be sold shall be paid in full to the Vendor

 

ARTICLE 6

 

CONFIDENTIALITY

 

		6.1	Confidentiality

 

For so long as the Corporation carries
on business, each Shareholder shall keep confidential any trade secret, patent, know-how or secret, technical expertise, customer
list or non-public information of any sort relating to the business carried on by the Corporation, as may from time to time be
acquired by it by virtue of being a Shareholder, officer, agent, director or employee of the Corporation, and shall use its best
efforts to prevent communication of such information to others, even after such Shareholder ceases to own, directly or indirectly,
Shares, provided that a party's obligations to disclose information requested pursuant to applicable laws shall supersede its obligations
pursuant to this provision. The provisions hereof are in addition to and not in substitution for any confidentiality agreement
executed by any party hereto.

 

ARTICLE 7

 

GENERAL

 

		7.1	Share Certificates

 

All certificates representing Shares shall
have endorsed thereon the following notation:

 

"The shares represented
by this certificate are subject to the terms of a Shareholders Agreement dated ■ as amended from time to time, among the
shareholders of the Corporation and the Corporation and others. Such shares may not be sold, transferred, pledged, hypothecated
or otherwise disposed of except in accordance with the provisions thereof herewith."

 

		7.2	Assignment and Enurement

 

This Agreement is not assignable
by any party except insofar as its benefit and burden pass with the Shares transferred in accordance with the provisions of this
Agreement. This Agreement shall enure to the benefit of and be binding upon the successors and permitted assigns of the parties
hereto.

 

		7.3	Notices

 

Any instrument, notice, consent, request
or election required or permitted to be given under this Agreement shall be in writing and delivered personally or transmitted
by telecopier or other form of recorded communication or, except in the event of disruption or threatened disruption of postal
service, mailed by prepaid registered mail addressed to the party to whom it is to be given at his address as shown below and such
notice shall be deemed to have been given on the next day after delivery or transmission or on the fourth business day after mailing
as aforesaid, as the case may be,

 

    	~ 15 ~

    	 

    

  

	if to AAA Holdco or Exchangeco:	■	 
	 	 	 
	 	■	 
	 	 	 
	 	Attention:	■
	 	 	 
	 	Fax:	■
	 	 	 
	if to Atreus Holdco: 	■	 
	 	 	 
	 	■	 
	 	 	 
	 	Attention:	■
	 	 	 
	 	Fax:	■
	 	 	 
	if to the Corporation:	 	 
	 	 	 
	 	Attention:	■
	 	 	 
	 	Fax	■

 

Notice of change of address may be given
to any party in the same manner.

 

		7.4	Time of Essence

 

Time shall be of the
essence of this Agreement.

 

		7.5	Further Assurances

 

The parties hereto hereby' agree
to execute or cause to be executed such other documents, instruments and certificates as may be required to effectively carry out
the terms and conditions of this Agreement.

 

		7.6	CounterpaIis

 

This Agreement may be executed
in one or more counterparts each of which shall be deemed to be an original and such counterparts together shall constitute but
one and the same instrument.

 

		7.7	Waivers - In this Agreement:

 

(a)    Not
a Waiver of Other Rights - A waiver by any party of its rights hereunder or of the performance by any other party of any of
its obligations hereunder shall be without prejudice to all or any of the other rights hereunder of the party so waiving and shall
not constitute a waiver of any other such rights or, in any other instances, of the rights so waived or a waiver of performance
by the party of any of its other obligations hereunder or the performance, in any other instance, of the obligations so waived.

 

    	~ 16 ~

    	 

    

  

(b)    In
Writing - No waiver on behalf of any party of the breach of any of the covenants, conditions and provisions herein contained
shall be effective or binding upon such other party unless the same shall be expressed in writing.

 

		7.8	Termination

 

This Agreement terminates
upon the first to occur of:

 

(a)     
the date this Agreement is terminated by the written approval by Shareholders holding at least sixty-six and two-thirds percent
(66 2/3%) of the outstanding shares of the Corporation;

 

(b)     the
date that is immediately prior to a Public Offering by the Corporation;

 

(c)     the
date that the Corporation is wound-up, liquidated or dissolved, whether voluntarily or involuntarily; and

 

(d)     that
date that one Person becomes the beneficial owner of all of the Shares.

 

		7.9	Amendment

 

No amendment, supplement or modification
of this Agreement and, unless otherwise specified, no waiver, consent or approval by any Party, is binding unless approved by the
Board, and approved in writing by Shareholders holding at least sixty-six and two-thirds percent (66 2/3 %) of the outstanding
shares of the Corporation and any amendment, supplement, modification, waiver, consent or approval so approved shall be binding
upon each of the Parties, but only if no Shareholder, without its consent, is materially and adversely affected by any such amendment,
supplement, modification, waiver, consent or approval in any maimer in which the other Shareholders are not likewise adversely
affected.

 

		7.10	Facsimile Delivery

 

This Agreement may be delivered
upon the provision of telefaxed execution pages provided that the party delivering such telefaxed execution pages shall as soon
as practicable thereafter deliver to the other parties an originally executed execution page.

 

[The remainder of this page has been
left blank intentionally}

 

    	~ 17 ~

    	 

    

  

IN WITNESS WHEREOF the parties hereto
have executed this Agreement on the date set out above.

 

	 	ADVANCED ACCELERATOR
	 	 
	 	APPLICATIONS CANADA INC.
	 	 	 
	 	By: 	/s/ Stefano Buono
	 	 	 
	 	Name: 	 Stefano Buono
	 	 	 
	 	Title:	 President

  

 

	 	4549694 CANADA INC.
	 	 	 
	 	By: 	/s/ Stefano Buono
	 	 	
	 	Name:  	Stefano Buono
	 	 	 
	 	Title:	President

  

 

	 	7329563  CANADA  INC.
	 	 
	 	By: 	 

  

	 	Name:  
	 	 
	 	Title
	 	 	 
	 	ATREUS  PHARMACEUTICALS
	 	 
	 	CORPORATION

  

	 	By: 	 

  

	 	Name: 
	 	 	 
	 	Title:

 

    	~ 18 ~EX-4.1

 Exhibit 4.1 

EXECUTION VERSION 
  

 
 FOURTH SUPPLEMENTAL INDENTURE

 GILEAD SCIENCES, INC. 

AND 
 WELLS FARGO BANK,
NATIONAL ASSOCIATION, 
 AS TRUSTEE 

Fourth Supplemental Indenture 

Dated as of November 17, 2014 

Supplementing the Indenture 

Dated as of March 30, 2011 

2.350% Senior Notes due 2020 

3.500% Senior Notes due 2025 

4.500% Senior Notes due 2045 
  

 

 FOURTH SUPPLEMENTAL INDENTURE, dated as of November 17, 2014 (this “Fourth
Supplemental Indenture”), between Gilead Sciences, Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”), and Wells Fargo Bank, National Association, a national banking
association, as Trustee (herein called the “Trustee”); 
 RECITALS: 

WHEREAS, the Company and the Trustee have heretofore executed and delivered an Indenture, dated as of March 30, 2011 (as
heretofore supplemented, the “Base Indenture” and, together with the Fourth Supplemental Indenture, the “Indenture”), providing for the issuance from time to time of the Company’s debentures, notes or other
evidences of indebtedness (herein and therein called the “Securities”), to be issued in one or more series as provided in the Base Indenture;  

WHEREAS, Section 12.1 of the Base Indenture permits the Company and the Trustee to enter into an indenture supplemental to the Base
Indenture to establish the form and terms of any series of Securities; 
 WHEREAS, Section 2.1 of the Base Indenture permits the form
of Securities of any series to be established in an indenture supplemental to the Base Indenture; 
 WHEREAS, Section 3.1 of the Base
Indenture permits certain terms of any series of Securities to be established pursuant to an indenture supplemental to the Base Indenture; 

WHEREAS, pursuant to Sections 2.1 and 3.1 of the Base Indenture, the Company desires to provide for the establishment of three new series of
Securities under the Base Indenture, the form and substance of such Securities and the terms, provisions and conditions thereof to be set forth as provided in the Base Indenture and this Fourth Supplemental Indenture; and 

WHEREAS, all things necessary to make this Fourth Supplemental Indenture a valid agreement of the Company, in accordance with its terms, have
been done. 
 NOW, THEREFORE, for and in consideration of the foregoing and the purchase of the Securities of three new series
established by this Fourth Supplemental Indenture by the holders thereof (the “Holders”), it is mutually agreed, for the equal and proportionate benefit of all such Holders, as follows:  

ARTICLE 1 

DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 

Section 1.01 Relation to Base Indenture. This Fourth Supplemental Indenture constitutes a part of the Base Indenture
(the provisions of which, as modified by this Fourth Supplemental Indenture, shall apply to each series of Notes (as defined in Section 4.01(a))) in respect of such series of Notes but shall not modify, amend or otherwise affect the Base
Indenture insofar as it relates to any other series of Securities or modify, amend or otherwise affect in any manner the terms and conditions of the Securities of any other series. 

  
 1 

 Section 1.02 Definitions. For all purposes of this Fourth
Supplemental Indenture, the capitalized terms used herein (i) which are defined in this Section 1.02 have the respective meanings assigned hereto in this Section 1.02 and (ii) which are defined in the Base Indenture (and which
are not defined in this Section 1.02) have the respective meanings assigned thereto in the Base Indenture. For all purposes of this Fourth Supplemental Indenture:  

(a) Unless the context otherwise requires, any reference to an Article or Section refers to an Article or Section, as the case may be, of this
Fourth Supplemental Indenture; 
 (b) The words “herein,” “hereof” and “hereunder” and words of similar import
refer to this Fourth Supplemental Indenture as a whole and not to any particular Article, Section or other subdivision; 
 (c) Headings are
for convenience of reference only and do not affect interpretations; and 
 (d) The terms defined in this Section 1.02(d) have the
meanings assigned to them in this Section and include the plural as well as the singular: 
 “Notes” has the meaning set
forth in Section 4.01(a). 
 ARTICLE 2 

GENERAL TERMS AND CONDITIONS OF THE 2020 NOTES  

Section 2.01 Terms of the 2020 Notes. Pursuant to Sections 2.1 and 3.1 of the Base Indenture, there is hereby
established a new series of Securities, the terms of which shall be as follows:  
 (a) Designation. There is hereby authorized
and established a new series of Securities under the Base Indenture, known and designated as the “2.350% Senior Notes due 2020” (the “2020 Notes”) of the Company. This series of 2020 Notes is unlimited in aggregate principal
amount. The initial aggregate principal amount of the 2020 Notes to be issued under this Fourth Supplemental Indenture shall be $500,000,000. Any additional amounts of the 2020 Notes to be issued shall be set forth in a Company Order. 

(b) Form and Denominations. The 2020 Notes will be issued only in fully registered form, and the authorized denominations of the 2020
Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2020 Notes will initially be issued in the form of one or more Global Securities substantially in the form of Exhibit A attached hereto,
with such modifications thereto as may be approved by the authorized officer executing the same. The 2020 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and interest will be made in U.S. dollars. 

(c) Maturity Date. The Stated Maturity of principal for the 2020 Notes shall be payable in full on February 1, 2020 (the
“2020 Notes Maturity Date”). 

  
 2 

 (d) Interest. Interest payable on any 2020 Notes Interest Payment Date (as defined below),
the 2020 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately preceding 2020 Notes Interest Payment Date
in respect of which interest has been paid or duly provided for (or from and including the original issue date of November 17, 2014 if no interest has been paid or duly provided for with respect to the 2020 Notes) to but excluding such 2020
Notes Interest Payment Date, 2020 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2020 Notes Interest Period”). The 2020 Notes will bear interest at the rate of 2.350% per year from the
original issue date thereof to the 2020 Notes Maturity Date. Interest on the 2020 Notes shall be payable semi-annually in arrears on February 1 and August 1 of each year, beginning on August 1, 2015 (each such date, a “2020
Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2020 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the event any 2020 Notes Interest Payment
Date on or before the 2020 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall accrue as a result of such postponement.

 In the event the 2020 Notes Maturity Date or a Redemption Date for any Note falls on a day that is not a Business Day, then the related
payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional interest will accumulate on the amount payable for the period from and after the 2020 Notes Maturity Date for such
2020 Note). Interest due on the 2020 Notes Maturity Date or a Redemption Date (in each case, whether or not a 2020 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2020 Notes is payable. 

(e) Sinking Fund; Holder Repurchase Right. The 2020 Notes shall not be subject to any sinking fund or analogous provision or be
redeemable at the option of the Holders. 
 (f) Forms. The 2020 Notes shall be substantially in the form of Exhibit A
attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g) Appointment of
Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2020 Notes. 
 (h) Defeasance. Until the
applicable 2020 Notes Maturity Date, the 2020 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 
 (i) Further
Issues. The Company may from time to time, without the consent of the Holders of 2020 Notes, issue additional 2020 Notes. Any such additional 2020 Notes will have the same ranking, interest rate, maturity date and other terms as the 2020 Notes.
Any such additional 2020 Notes, together with the 2020 Notes herein provided for, will constitute a single series of Securities under the Indenture. 

  
 3 

 ARTICLE 3 

GENERAL TERMS AND CONDITIONS OF THE 2025 NOTES  

Section 3.01 Terms of the 2025 Notes. Pursuant to Sections 2.1 and 3.1 of the Base Indenture, there is hereby
established a new series of Securities, the terms of which shall be as follows:  
 (a) Designation. There is hereby authorized
and established a new series of Securities under the Base Indenture, known and designated as the “3.500% Senior Notes due 2025” (the “2025 Notes”) of the Company. This series of 2025 Notes is unlimited in aggregate
principal amount. The initial aggregate principal amount of the 2025 Notes to be issued under this Fourth Supplemental Indenture shall be $1,750,000,000. Any additional amounts of the 2025 Notes to be issued shall be set forth in a Company Order.

 (b) Form and Denominations. The 2025 Notes will be issued only in fully registered form, and the authorized denominations of the
2025 Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2025 Notes will initially be issued in the form of one or more Global Securities substantially in the form of Exhibit B attached
hereto, with such modifications thereto as may be approved by the authorized officer executing the same. The 2025 Notes will be denominated in U.S. dollars and payments of principal, premium, if any, and interest will be made in U.S. dollars. 

(c) Maturity Date. The Stated Maturity of principal for the 2025 Notes shall be payable in full on February 1, 2025 (the
“2025 Notes Maturity Date’’). 
 (d) Interest. Interest payable on any 2025 Notes Interest Payment Date (as
defined below), the 2025 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately preceding 2025 Notes
Interest Payment Date in respect of which interest has been paid or duly provided for (or from and including the original issue date of November 17, 2014 if no interest has been paid or duly provided for with respect to the 2025 Notes) to but
excluding such 2025 Notes Interest Payment Date, 2025 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2025 Notes Interest Period”). The 2025 Notes will bear interest at the rate of
3.500% per year from the original issue date thereof to the 2025 Notes Maturity Date. Interest on the 2025 Notes shall be payable semi-annually in arrears on February 1 and August 1 of each year, beginning on August 1, 2015 (each
such date, a “2025 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2025 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the event any
2025 Notes Interest Payment Date on or before the 2025 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall accrue as a
result of such postponement. 
 In the event the 2025 Notes Maturity Date or a Redemption Date for any Note falls on a day that is not a
Business Day, then the related payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional 

  
 4 

 
interest will accumulate on the amount payable for the period from and after the 2025 Notes Maturity Date for such 2025 Note). Interest due on the 2025 Notes Maturity Date or a Redemption Date
(in each case, whether or not a 2025 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2025 Notes is payable. 

(e) Sinking Fund; Holder Repurchase Right. The 2025 Notes shall not be subject to any sinking fund or analogous provision or be
redeemable at the option of the Holders. 
 (f) Forms. The 2025 Notes shall be substantially in the form of Exhibit B
attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 
 (g) Appointment of
Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2025 Notes. 
 (h) Defeasance. Until the
applicable 2025 Notes Maturity Date, the 2025 Notes will be subject to Sections 11.2 and 11.3 of the Base Indenture. 
 (i) Further
Issues. The Company may from time to time, without the consent of the Holders of 2025 Notes, issue additional 2025 Notes. Any such additional 2025 Notes will have the same ranking, interest rate, maturity date and other terms as the 2025 Notes.
Any such additional 2025 Notes, together with the 2025 Notes herein provided for, will constitute a single series of Securities under the Indenture. 

ARTICLE 4 

GENERAL TERMS AND CONDITIONS OF THE 2045 NOTES  

Section 4.01 Terms of the 2045 Notes. Pursuant to Sections 2.1 and 3.1 of the Base Indenture, there is hereby
established a new series of Securities, the terms of which shall be as follows:  
 (a) Designation. There is hereby authorized
and established a new series of Securities under the Base Indenture, known and designated as the “4.500% Senior Notes due 2045” (the “2045 Notes” and, together with the 2020 Notes and 2025 Notes, the
“Notes”) of the Company. This series of 2045 Notes is unlimited in aggregate principal amount. The initial aggregate principal amount of the 2045 Notes to be issued under this Fourth Supplemental Indenture shall be $1,750,000,000.
Any additional amounts of the 2045 Notes to be issued shall be set forth in a Company Order. 
 (b) Form and Denominations. The 2045
Notes will be issued only in fully registered form, and the authorized denominations of the 2045 Notes shall be $2,000 principal amount and any integral multiple of $1,000 in excess thereof. The 2045 Notes will initially be issued in the form of one
or more Global Securities substantially in the form of Exhibit C attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. The 2045 Notes will be denominated in U.S. dollars and
payments of principal, premium, if any, and interest will be made in U.S. dollars. 

  
 5 

 (c) Maturity Date. The Stated Maturity of principal for the 2045 Notes shall be payable in
full on February 1, 2045 (the “2045 Notes Maturity Date”). 
 (d) Interest. Interest payable on any 2045 Notes
Interest Payment Date (as defined below), the 2045 Notes Maturity Date, or if applicable, the Redemption Date (as determined in accordance with Section 4.2 of the Base Indenture) shall be the amount accrued from, and including, the immediately
preceding 2045 Notes Interest Payment Date in respect of which interest has been paid or duly provided for (or from and including the original issue date of November 17, 2014 if no interest has been paid or duly provided for with respect to the
2045 Notes) to but excluding such 2045 Notes Interest Payment Date, 2045 Notes Maturity Date or, if applicable, Redemption Date, as the case may be (each, a “2045 Notes Interest Period”). The 2045 Notes will bear interest at the
rate of 4.500% per year from the original issue date thereof to the 2045 Notes Maturity Date. Interest on the 2045 Notes shall be payable semi-annually in arrears on February 1 and August 1 of each year, beginning on August 1,
2015 (each such date, a “2045 Notes Interest Payment Date”). The amount of interest payable for any semi-annual 2045 Notes Interest Period will be computed on the basis of a 360-day year consisting of twelve 30-day months. In the
event any 2045 Notes Interest Payment Date on or before the 2045 Notes Maturity Date falls on a day that is not a Business Day, the interest payment due on that date will be postponed to the next day that is a Business Day and no interest shall
accrue as a result of such postponement. 
 In the event the 2045 Notes Maturity Date or a Redemption Date for any Note falls on a day that
is not a Business Day, then the related payments of principal, premium, if any, and interest may be made on the next succeeding date that is a Business Day (and no additional interest will accumulate on the amount payable for the period from and
after the 2045 Notes Maturity Date for such 2045 Note). Interest due on the 2045 Notes Maturity Date or a Redemption Date (in each case, whether or not a 2045 Notes Interest Payment Date) will be paid to the Person to whom principal of such 2045
Notes is payable. 
 (e) Sinking Fund; Holder Repurchase Right. The 2045 Notes shall not be subject to any sinking fund or analogous
provision or be redeemable at the option of the Holders. 
 (f) Forms. The 2045 Notes shall be substantially in the form of
Exhibit C attached hereto, with such modifications thereto as may be approved by the authorized officer executing the same. 

(g) Appointment of Agent. The Trustee will initially be the Registrar and Paying Agent with respect to the 2045 Notes. 

(h) Defeasance. Until the applicable 2045 Notes Maturity Date, the 2045 Notes will be subject to Sections 11.2 and 11.3 of the Base
Indenture. 
 (i) Further Issues. The Company may from time to time, without the consent of the Holders of 2045 Notes, issue
additional 2045 Notes. Any such additional 2045 Notes will have the same ranking, interest rate, maturity date and other terms as the 2045 Notes. Any such additional 2045 Notes, together with the 2045 Notes herein provided for, will constitute a
single series of Securities under the Indenture. 

  
 6 

 ARTICLE 5 

EVENTS OF DEFAULT 

Section 5.01. Events of Default. Pursuant to Section 7.1 of the Base Indenture, the term “Event of Default”
with respect to each series of Notes shall include, in addition to those otherwise set forth in Section 7.1 of the Base Indenture, the following: the occurrence with respect to any Debt of the Company individually or in the aggregate in excess
of $100,000,000 of (a) an event of default that results in such Debt becoming due and payable prior to its scheduled maturity (after giving effect to any applicable grace period) or (b) the failure to make any payment when due (including
any applicable grace period) which results in the acceleration of the maturity of such Debt, in each case without such acceleration having been rescinded, annulled or otherwise cured. 

ARTICLE 6 

REDEMPTION OF THE NOTES 

Section 6.01 Optional Redemption by Company. Each series of Notes may be redeemed at the option of the Company on the terms
and conditions set forth in the form of Note as set forth as Exhibit A, Exhibit B or Exhibit C, as applicable. 

ARTICLE 7 

CHANGE OF CONTROL 

Section 7.01 Offer to Purchase Upon Change of Control Triggering Event. Upon the occurrence of a Change of Control
Triggering Event (as defined in the form of Note set forth as Exhibit A, Exhibit B or Exhibit C, as applicable), except with respect to any series of Notes for which the Company has exercised its option to redeem the Notes
of such series in full pursuant to Section 6.01, the Company shall be required to make an offer to each Holder of the applicable series of Notes to repurchase all or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof)
of that Holder’s applicable series of Notes on the terms and conditions set forth in the form of Note set forth as Exhibit A, Exhibit B or Exhibit C, as applicable. 

ARTICLE 8 

MISCELLANEOUS 

Section 8.01 Relationship to Existing Base Indenture. This Fourth Supplemental Indenture is a supplemental
indenture within the meaning of the Base Indenture. The Base Indenture, as supplemented and amended by this Fourth Supplemental Indenture, is in all respects ratified, confirmed and approved and, with respect to each series of Notes, the Base
Indenture, as supplemented and amended by this Fourth Supplemental Indenture, shall be read, taken and construed as one and the same instrument. 

  
 7 

 Section 8.02 Modification of the Existing Base Indenture. Except
as expressly modified by this Fourth Supplemental Indenture, the provisions of the Base Indenture shall govern the terms and conditions of each series of Notes.  

Section 8.03 Governing Law. This Fourth Supplemental Indenture shall be governed by and construed in
accordance with the laws of the State of New York. 
 Section 8.04 Counterparts. This Fourth
Supplemental Indenture may be executed in any number of counterparts, each of which when so executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument.  

Section 8.05 Trustee Makes No Representation. The recitals contained herein are made by the Company and not
by the Trustee, and the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no representation as to the validity or sufficiency of this Fourth Supplemental Indenture (except for its execution thereof and its certificates
of authentication of any series of Notes).  
 Section 8.06 Separability. In case any provision in the Base
Indenture, this Fourth Supplemental Indenture or any series of Notes shall for any reason be held to be invalid, illegal or unenforceable, the validity, legality or enforceability of the remaining provisions shall not in any way be affected or
impaired thereby. 
 [Signature page follows] 

  
 8 

 IN WITNESS WHEREOF, the parties hereto have caused this Fourth Supplemental Indenture to
be duly executed and attested all as of the day and year first above written.  
 Date: November 17, 2014 

 

					
	GILEAD SCIENCES, INC.,
	as Issuer
		
	 By:
	 	 /s/ Robin L. Washington

		 	 Name:
	 	Robin L. Washington
		 	 Title:
	 	Executive Vice President and Chief
		 		 	Financial Officer

  

					
	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,

	as Trustee
		
	 By:
	 	 /s/ Martin Reed

		 	 Name:
	 	Martin Reed
		 	 Title:
	 	Vice President

 [Fourth Supplemental Indenture] 

 EXHIBIT A 

FORM OF 2020 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

			
	No.     	  	 CUSIP NO. 375558 AY9

$            

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of              DOLLARS ($        ), as revised by the Schedule of Increases or Decreases in Global Security attached
hereto, on February 1, 2020 and to pay interest thereon from November 17, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually on February 1 and August 1 in each
year, commencing August 1, 2015, at the rate of 2.350% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the January 15 or July 15
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the 

  
 A-1 

 
Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special
Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other
lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Trustee maintained
for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Authentication. Unless the certificate of authentication hereon has
been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.  

  
 A-2 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

					
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	 Name:
 Title:
	 	

 [Global 2020 Note] 

  
 A-3 

 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

							
	Date of authentication:	 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as Trustee

				
		 		 	By:	 	  

		 		 		 	Authorized Signatory

  
 A-4 

 [FORM OF REVERSE OF 2020 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fourth Supplemental Indenture dated as of November 17, 2014 (herein called the “Fourth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $500,000,000. The Company may at any time issue additional securities under the Indenture in unlimited
amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject to
redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 12.5 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 A-5 

 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 
 “Independent
Investment Banker” means the Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer”
means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC, their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to
be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

In the event of redemption of this Security in part only, a new Security or Securities of this series and of like tenor for the unredeemed
portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 
 Change of Control. If a
Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000
in excess thereof), of each Holder’s Securities pursuant to the offer described below (the “Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment
in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the
rights of Holders of Securities on the relevant record date to receive interest due on the relevant Interest Payment Date. 

Within 30 days following any Change of Control Triggering Event or, at the Company’s option, prior to any Change of Control but
after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the transaction or transactions that constitute or may constitute the Change of Control Triggering
Event and offering to repurchase the Securities on the date specified in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”),
pursuant to the procedures required herein and described in such notice. The Company must comply with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other
securities  

  
 A-6 

 
laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To
the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be required to comply with the applicable securities laws and regulations and will not be deemed to have
breached its obligations under the Change of Control provisions herein by virtue of such conflicts. 
 On the Change of Control Payment
Date, the Company will be required, to the extent lawful, to: 
 (a) accept for payment all Securities or portions of Securities properly
tendered, and not validly withdrawn, pursuant to the Change of Control Offer; 
 (b) deposit with the Paying Agent an amount equal to the
Change of Control Payment in respect of all Securities or portions of Securities properly tendered and not validly withdrawn; and 
 (c)
deliver or cause to be delivered to the Trustee the Securities properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such
Securities and the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any;
provided that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof.  

Notwithstanding the foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the
occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for such an offer made by the Company and the third party purchases all such
Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 

For purposes of the foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 

“Capital Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such
capital stock shall be limited to a fixed sum or percentage with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of
such corporation.  

  
 A-7 

 “Change of Control” means the occurrence of any of the following: 

(a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other
than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the “beneficial owner” (as defined in Rule
13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; 
 (c) the Company consolidates, or merges with or into any person, or any person
consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property,
other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any
direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 
 (d) the first day on which
a majority of the Company’s members of its board of directors are not Continuing Directors; or 
 (e) the adoption of a plan relating
to the Company’s liquidation or dissolution. 
 Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be
considered to be a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the
holding company are substantially the same as the holders of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more
than 50% of the Voting Stock of such holding company. 
 “Change of Control Triggering Event” means the occurrence of both
a Change of Control and a Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member
of the Company’s board of directors who (a) was a member of such board of directors on November 17, 2014 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the
Continuing Directors who were members of such board of directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a
director). 

  
 A-8 

 “Investment Grade” means a rating of Baa3 or better by Moody’s (or
its equivalent under any successor rating categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional
Rating Agency or Rating Agencies selected by the Company.  
 “Moody’s” means Moody’s Investors Service,
Inc., a subsidiary of Moody’s Corporation, and its successors. 
 “Rating Agencies” means (a) each of
Moody’s and S&P; and (b) if any of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized
statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or
S&P, or both of them, as the case may be. 
 “Rating Event” means, with respect to the Securities, the rating on
the Securities is lowered below Investment Grade by each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice
of the occurrence of the Change of Control (which 60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and
its successors.  
 “Voting Stock” means, with respect to any specified person as of any date, the Capital
Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The
Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth
in the Indenture, which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No
reference herein to the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security
at the respective due dates, place and rate, and in the Currency herein prescribed. 
 Default and Remedies. If an Event of Default
with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be  

  
 A-9 

 
affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time outstanding, on behalf of the
Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security
shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or
waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the Indenture and subject to certain
limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and
any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or the Holder’s attorney duly
authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.  

The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral multiple of $1,000 in excess
thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different authorized
denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for any such registration of
transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 
 All terms used in this Security and not defined
herein shall have the meanings assigned to them in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform
Security Identification Procedures, the Company has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers
as printed on the Securities, and reliance may be placed only on the other identification numbers printed hereon. 

  
 A-10 

 Unless the certificate of authentication hereon has been executed by or on behalf of the Trustee
by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 A-11 

 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 
   

 
 (Please Print or Typewrite Name and Address, including
Zip Code, of Assignee) 
  
   

 
 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint 
  

  
  

Attorney to transfer said Security on the books of the within-named Company with full power of substitution in the premises 

 

			
	 Dated:
	 	  

  

			
	 Signature
	 	  

 NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security
in every particular, without alteration or enlargement or any change whatever. 
  

			
	 Signature
	 	
	 Guaranteed:
	 	  

 NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or
participant in a “signature guarantee program” (e.g., the Securities Transfer Agents Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program). 

  
 A-12 

 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of

Exchange
	  	Amount of increase in
Principal Amount of
this Global Security	  	Amount of decrease
in Principal Amount
of this Global Security	  	Principal Amount of
this Global Security
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee
		  		  		  		  	

  
 A-13 

 EXHIBIT B 

FORM OF 2025 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.  
 GILEAD SCIENCES, INC. 

 

					
	 No.     
	  	 	CUSIP NO. 375558 AZ6	  

 $             

Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the State of Delaware (herein called
the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered assigns, the principal sum of
            DOLLARS ($            ), as revised by the Schedule of Increases or Decreases in Global Security attached hereto, on
February 1, 2025 and to pay interest thereon from November 17, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually on February 1 and August 1 in each year,
commencing August 1, 2015, at the rate of 3.500% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the January 15 or July 15
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the

  
 B-1 

 
Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special
Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other
lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Trustee maintained
for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Authentication. Unless the certificate of authentication hereon has
been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.  

  
 B-2 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	 By:
	 	  

		 	 Name:
 Title:

 [Global 2025 Note] 

  
 B-3 

 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

							
	Date of authentication:	 		 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as Trustee

				
		 		 	By:	 	  

		 		 		 	Authorized Signatory

  
 B-4 

 [FORM OF REVERSE OF 2025 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fourth Supplemental Indenture dated as of November 17, 2014 (herein called the “Fourth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,750,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 20 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 B-5 

 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 
 “Independent
Investment Banker” means the Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer”
means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC, their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to
be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

The Securities of this series are also subject to redemption at the Company’s option, at any time on or after November 1, 2024, in
whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the records of the Registrar, at a Redemption Price equal to 100% of the principal amount
of the Securities to be redeemed, plus accrued and unpaid interest to the Redemption Date. 
 In the event of redemption of this Security in
part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 

Change of Control. If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem
the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof), of each Holder’s Securities pursuant to the offer described below (the
“Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued
and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the rights of Holders of Securities on the relevant record date to receive interest due on the
relevant Interest Payment Date. 
 Within 30 days following any Change of Control Triggering Event or, at the Company’s option,
prior to any Change of Control but after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the 

  
 B-6 

 
transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Securities on the date specified in the notice, which date
will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required herein and described in such notice. The Company must comply
with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in
connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be
required to comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control provisions herein by virtue of such conflicts.  

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(a) accept for payment all Securities or portions of Securities properly tendered, and not validly withdrawn, pursuant to the Change of Control
Offer; 
 (b) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities or portions of
Securities properly tendered and not validly withdrawn; and 
 (c) deliver or cause to be delivered to the Trustee the Securities properly
accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such
Securities and the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any;
provided that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof.  

Notwithstanding the foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the
occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for such an offer made by the Company and the third party purchases all such
Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 

For purposes of the foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 

“Capital Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such
capital stock shall be limited to a fixed sum or percentage with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of
such corporation.  

  
 B-7 

 “Change of Control” means the occurrence of any of the following: 

(a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other
than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the “beneficial owner” (as defined in Rule
13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; 
 (c) the Company consolidates, or merges with or into any person, or any person
consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property,
other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any
direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 
 (d) the first day on which
a majority of the Company’s members of its board of directors are not Continuing Directors; or 
 (e) the adoption of a plan relating
to the Company’s liquidation or dissolution. 
 Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be
considered to be a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the
holding company are substantially the same as the holders of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more
than 50% of the Voting Stock of such holding company. 
 “Change of Control Triggering Event” means the occurrence of both
a Change of Control and a Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member
of the Company’s board of directors who (a) was a member of such board of directors on November 17, 2014 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the
Continuing Directors who were members of such board of  

  
 B-8 

 
directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a
director). 
 “Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any
successor rating categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency or Rating
Agencies selected by the Company.  
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of
Moody’s Corporation, and its successors. 
 “Rating Agencies” means (a) each of Moody’s and S&P;
and (b) if any of Moody’s or S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating
organization” within the meaning of Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or S&P, or both
of them, as the case may be. 
 “Rating Event” means, with respect to the Securities, the rating on the Securities
is lowered below Investment Grade by each of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the
occurrence of the Change of Control (which 60-day period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and
its successors.  
 “Voting Stock” means, with respect to any specified person as of any date, the Capital
Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The
Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth
in the Indenture, which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No
reference herein to the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security
at the respective due dates, place and rate, and in the Currency herein prescribed. 
 Default and Remedies. If an Event of Default
with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

  
 B-9 

 Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as
therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee
with the consent of the Holders of a majority in principal amount of the Securities at the time outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of
the Securities of each series at the time outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their
consequences. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange
herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 
 Denominations;
Transfer and Exchange. As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer
at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the
Registrar duly executed by, the Holder hereof or the Holder’s attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal
amount, will be issued to the designated transferee or transferees.  
 The Securities of this series are issuable only in registered
form in denominations of $2,000 and any integral multiple of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal
amount of Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. 

No service charge shall be made to a Holder for any such registration of transfer or exchange, but the Company may require payment of a sum
sufficient to cover any tax or other governmental charge payable in connection therewith. 
 Persons Deemed Owners. Prior to due
presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this
Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.  

Miscellaneous. The Indenture and the Securities, including this Security, shall be governed by and construed in accordance
with the laws of the State of New York. 
 All terms used in this Security and not defined herein shall have the meanings assigned to
them in the Indenture. 

  
 B-10 

 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification
Procedures, the Company has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers as printed on the
Securities, and reliance may be placed only on the other identification numbers printed hereon. 
 Unless the certificate of authentication
hereon has been executed by or on behalf of the Trustee by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 B-11 

 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 
  

(Please Print or Typewrite Name and Address, including Zip Code, of Assignee) 
  

 
 the within Security of Gilead Sciences, Inc. and
                     hereby does irrevocably constitute and appoint 
  

 
 Attorney to transfer said Security on the books of the
within-named Company with full power of substitution in the premises 
  

			
	 Dated:
	 	  

  

			
	 Signature
	 	  

 NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security
in every particular, without alteration or enlargement or any change whatever. 
  

			
	 Signature
	 	
	 Guaranteed:
	 	  

 NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or
participant in a “signature guarantee program” (e.g., the Securities Transfer Agents Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program). 

  
 B-12 

 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of Exchange
	  	Amount of increase in
Principal Amount of
this Global Security	  	Amount of decrease
in Principal Amount
of this Global
Security	  	Principal Amount of
this Global Security
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee
		  		  		  		  	

  
 B-13 

 EXHIBIT C 

FORM OF 2045 SENIOR NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY
OR A NOMINEE OF THE DEPOSITARY WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE OR ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS SECURITY FOR ALL PURPOSES. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 GILEAD SCIENCES, INC. 

 

			
	No.     	  	 CUSIP NO. 375558 BA0

$            

 Interest. Gilead Sciences, Inc., a corporation duly incorporated and existing under the laws of the
State of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co., or registered
assigns, the principal sum of                     DOLLARS ($        ), as revised by the Schedule of
Increases or Decreases in Global Security attached hereto, on February 1, 2045 and to pay interest thereon from November 17, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for,
semi-annually on February 1 and August 1 in each year, commencing August 1, 2015, at the rate of 4.500% per annum, until the principal hereof is paid or made available for payment.  

Method of Payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the January 15 or July 15
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the 

  
 C-1 

 
Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special
Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other
lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Trustee maintained
for that purpose in New York, New York, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Authentication. Unless the certificate of authentication hereon has
been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.  

  
 C-2 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

			
	GILEAD SCIENCES, INC.
		
	By:	 	  

		 	 Name:
 Title:

 [Global 2045 Note] 

  
 C-3 

 [FORM OF CERTIFICATION OF AUTHENTICATION] 

CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

 

					
	Date of authentication:	 	 WELLS FARGO BANK,

NATIONAL ASSOCIATION,
 as Trustee

			
		 	By:	 	  

		 		 	Authorized Signatory

  
 C-4 

 [FORM OF REVERSE OF 2045 NOTE] 

Indenture. This Security is one of a duly authorized issue of securities of the Company (herein called the
“Securities”), issued and to be issued in one or more series under an Indenture, dated as of March 30, 2011 (as heretofore supplemented, herein called the “Base Indenture”, which term shall have the meaning
assigned to it in such instrument), as supplemented by a Fourth Supplemental Indenture dated as of November 17, 2014 (herein called the “Fourth Supplemental Indenture”, and together with the Base Indenture, the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to
the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,750,000,000. The Company may at any time issue additional securities under the Indenture in
unlimited amounts having the same terms as the Securities.  
 Optional Redemption. The Securities of this series are subject
to redemption at the Company’s option, at any time and from time to time, in whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the
records of the Registrar, on any date prior to their Stated Maturity at a Redemption Price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption
Date or (ii) as determined by an Independent Investment Banker (as defined below), the sum of the present values of the remaining scheduled payments of principal and interest thereon (not including any portion of such payments of interest
accrued as of the Redemption Date) discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 25 basis points, plus in each case accrued and
unpaid interest thereon to the Redemption Date; provided that unless the Company defaults in payment of the Redemption Price, on or after the Redemption Date, interest will cease to accrue on the Securities or portions thereof called for
redemption. 
 For purposes of determining the optional redemption price, the following definitions are applicable: 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent
yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. The semi-annual equivalent
yield to maturity of the Comparable Treasury Issue will be computed as of the third business day immediately preceding the Redemption Date.  

“Comparable Treasury Issue” means the United States Treasury security or securities selected by the Independent
Investment Banker as having a maturity comparable to the remaining term of the Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of the Securities.  

  
 C-5 

 “Comparable Treasury Price” means, with respect to any Redemption Date,
(1) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Independent Investment Banker obtains fewer than four
Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 
 “Independent
Investment Banker” means the Reference Treasury Dealer appointed by the Company. 
 “Reference Treasury Dealer”
means Merrill Lynch, Pierce, Fenner & Smith Incorporated and J.P. Morgan Securities LLC, their successors and two other nationally recognized investment banking firms; provided, however, that, if the foregoing shall cease to
be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company shall substitute therefor another nationally recognized investment banking firm that is a Primary Treasury Dealer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the Securities (expressed in each case as a percentage of its principal amount) quoted in writing to the Independent
Investment Banker by such Reference Treasury Dealer at 3:30 p.m., New York City time, on the third Business Day preceding such Redemption Date.  

The Securities of this series are also subject to redemption at the Company’s option, at any time on or after August 1, 2044, in
whole or in part, upon not less than 30 nor more than 60 days’ notice mailed to each Holder of Securities to be redeemed at his address as it appears in the records of the Registrar, at a Redemption Price equal to 100% of the principal amount
of the Securities to be redeemed, plus accrued and unpaid interest to the Redemption Date. 
 In the event of redemption of this Security in
part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 

Change of Control. If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem
the Securities as described above, it will be required to make an offer to repurchase all, or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof), of each Holder’s Securities pursuant to the offer described below (the
“Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Securities repurchased plus accrued
and unpaid interest, if any, on the Securities repurchased, to the date of repurchase (the “Change of Control Payment”), subject to the rights of Holders of Securities on the relevant record date to receive interest due on the
relevant Interest Payment Date. 
 Within 30 days following any Change of Control Triggering Event or, at the Company’s option,
prior to any Change of Control but after the public announcement of the pending Change of Control, the Company will be required to mail a notice to Holders of Securities describing the 

  
 C-6 

 
transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Securities on the date specified in the notice, which date
will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required herein and described in such notice. The Company must comply
with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in
connection with the repurchase of the Securities as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions herein, the Company will be
required to comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control provisions herein by virtue of such conflicts.  

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(a) accept for payment all Securities or portions of Securities properly tendered, and not validly withdrawn, pursuant to the Change of Control
Offer; 
 (b) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities or portions of
Securities properly tendered and not validly withdrawn; and 
 (c) deliver or cause to be delivered to the Trustee the Securities properly
accepted together with an Officers’ Certificate stating the aggregate principal amount of Securities or portions of Securities being purchased by the Company. 

The Paying Agent will be required to mail promptly to each Holder who properly tendered Securities the purchase price for such
Securities and the Trustee will be required to authenticate and mail (or cause to be transferred by book entry) promptly to each such Holder a new Security equal in principal amount to any unpurchased portion of the Securities surrendered, if any;
provided that each new Security will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof.  

Notwithstanding the foregoing, the Company will not be required to make a Change of Control Offer with respect to the Securities upon the
occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for such an offer made by the Company and the third party purchases all such
Securities properly tendered and not validly withdrawn under its offer. Further, the Company will not be required to repurchase any Securities if there has occurred and is continuing on the Change of Control Payment Date an Event of Default. 

For purposes of the foregoing discussion of a repurchase at the option of Holders, the following definitions are applicable: 

“Capital Stock” means the capital stock of every class whether now or hereafter authorized, regardless of whether such
capital stock shall be limited to a fixed sum or percentage  

  
 C-7 

 
with respect to the rights of the holders thereof to participate in dividends and in the distribution of assets upon the voluntary or involuntary liquidation, dissolution or winding up of such
corporation. 
 “Change of Control” means the occurrence of any of the following: 

(a) the direct or indirect sale, lease, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the Company’s assets and the assets of its Subsidiaries, taken as a whole, to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other
than the Company or one of its Subsidiaries; 
 (b) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries, becomes the “beneficial owner” (as defined in Rule
13d-3 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s then outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; 
 (c) the Company consolidates, or merges with or into any person, or any person
consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of its Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property,
other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any
direct or indirect parent company of the surviving person immediately after giving effect to such transaction; 
 (d) the first day on which
a majority of the Company’s members of its board of directors are not Continuing Directors; or 
 (e) the adoption of a plan relating
to the Company’s liquidation or dissolution. 
 Notwithstanding paragraphs (a), (b) and (c) above, a transaction will not be
considered to be a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company and (b)(x) immediately following that transaction, the direct or indirect holders of the Voting Stock of the
holding company are substantially the same as the holders of the Company’s Voting Stock immediately prior to that transaction or (y) immediately following that transaction, no person is the beneficial owner, directly or indirectly, of more
than 50% of the Voting Stock of such holding company. 
 “Change of Control Triggering Event” means the occurrence of both
a Change of Control and a Rating Event. 
 “Continuing Directors” means, as of any date of determination, any member of the
Company’s board of directors who (a) was a member of such board of directors on November 

  
 C-8 

 
17, 2014 or (b) was nominated for election, elected or appointed to such board of directors with the approval of a majority of the Continuing Directors who were members of such board of
directors at the time of such nomination, election or appointment (either by a specific vote or by approval of a proxy statement in which such member was named as a nominee for election as a director). 

“Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating categories
of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected by the
Company. 
 “Moody’s” means Moody’s Investors Service, Inc., a subsidiary of Moody’s Corporation, and its
successors. 
 “Rating Agencies” means (a) each of Moody’s and S&P; and (b) if any of Moody’s or
S&P ceases to rate the Securities or fails to make a rating of the Securities publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of
Section 3(a)(62) of the Exchange Act that is selected by the Company (as certified by a resolution of the Company’s board of directors) as a replacement agency for Moody’s or S&P, or both of them, as the case may be. 

“Rating Event” means, with respect to the Securities, the rating on the Securities is lowered below Investment Grade by each
of the Rating Agencies on any date beginning on the date of public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the occurrence of the Change of Control (which 60-day
period shall be extended so long as the rating of the Securities is under publicly announced consideration for possible downgrade by any of the Rating Agencies). 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and its
successors. 
 “Voting Stock” means, with respect to any specified person as of any date, the Capital Stock of such person
that is at the time entitled to vote generally in the election of the board of directors of such person. 
 The Indenture contains
provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture,
which provisions apply to this Security. This Security is not subject to repayment at the Holder’s option. 
 No reference herein to
the Indenture and no provision of this Security or the Indenture shall affect or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of, premium, if any, and interest on this Security at the respective due
dates, place and rate, and in the Currency herein prescribed. 

  
 C-9 

 Default and Remedies. If an Event of Default with respect to Securities of this series
shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture.  

Amendment, Modification and Waiver. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of the Securities at the time outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time
outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by
the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not
notation of such consent or waiver is made upon this Security. 
 Denominations; Transfer and Exchange. As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the records of the Registrar, upon surrender of this Security for registration of transfer at the office or agency of the Company in any
place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or
the Holder’s attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or
transferees.  
 The Securities of this series are issuable only in registered form in denominations of $2,000 and any integral
multiple of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor
of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made to a Holder for
any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Persons Deemed Owners. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.  
 Miscellaneous. The Indenture and the Securities, including this Security, shall be
governed by and construed in accordance with the laws of the State of New York. 

  
 C-10 

 All terms used in this Security and not defined herein shall have the meanings assigned to them
in the Indenture. 
 Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company
has caused “CUSIP” numbers to be printed on the Securities as a convenience to the Holders of the Securities. No representation is made as to the correctness or accuracy of such CUSIP numbers as printed on the Securities, and reliance may
be placed only on the other identification numbers printed hereon. 
 Unless the certificate of authentication hereon has been executed by
or on behalf of the Trustee by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 C-11 

 ASSIGNMENT FORM 

FOR VALUE RECEIVED, the undersigned hereby 

sells, assigns and transfers unto 
 PLEASE INSERT
SOCIAL 
 SECURITY OR OTHER IDENTIFYING 
 NUMBER OF ASSIGNEE

  
  

 
  

(Please Print or Typewrite Name and Address, including Zip Code, of Assignee) 
  

 
 the within Security of Gilead Sciences, Inc. and
                    hereby does irrevocably constitute and appoint 
  

 
 Attorney to transfer said Security on the books of the
within-named Company with full power of substitution in the premises 
  

			
	 Dated:
	 	  

  

			
	 Signature
	 	  

 NOTICE: The signature to this assignment must correspond with the name as it appears on the first page of the within Security
in every particular, without alteration or enlargement or any change whatever. 
  

			
	 Signature
	 	
	 Guaranteed:
	 	  

 NOTICE: Signature(s) must be guaranteed by an “eligible guarantor institution” that is a member or
participant in a “signature guarantee program” (e.g., the Securities Transfer Agents Medallion Program, the Stock Exchange Medallion Program and the New York Stock Exchange Medallion Program). 

  
 C-12 

 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Global Security have been made: 

 

									
	 Date of Exchange
	  	Amount of increase in
Principal Amount of
this Global Security	  	Amount of decrease
in Principal Amount
of this Global
Security	  	Principal Amount of
this Global Security
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee
		  		  		  		  	

  
 C-13

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00237-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00237-of-00352.parquet"}]]