Document:

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                                                                    Exhibit 10.1

                            INDEMNIFICATION AGREEMENT

                  This Indemnification Agreement is made as of this ___ day of
__________, ____, by and between Aderis Pharmaceuticals, Inc., a Delaware
corporation (the "Company") and _______________ ("Indemnitee").

                              W I T N E S S E T H:

                  WHEREAS, the Company, in order to induce Indemnitee to serve
the Company as a _________, has agreed to provide Indemnitee with the benefits
contemplated by this Agreement;

                  WHEREAS, as a result of the provision of such benefits
Indemnitee has agreed to serve as a director of the Company;

                  WHEREAS, the By-laws of the Company and the Certificate of
Incorporation of the Company require the Company to indemnify its directors and
officers and others to the full extent permitted by law, and the Indemnitee has
agreed to serve as a director of the Company in part in reliance on such By-laws
and Certificate of Incorporation; and

                  WHEREAS, (x) in recognition of (A) Indemnitee's need for
protection against personal liability, in order to enhance Indemnitee's service
to the Company in an effective manner, and (B) Indemnitee's reliance on the
Company's By-laws and Certificate of Incorporation, and (y) in part to provide
Indemnitee with specific contractual assurance that the protection promised by
such By-laws and Certificate of Incorporation will be available to Indemnitee
(regardless of, among other things, any amendment to or revocation of such
By-laws or Certificate of Incorporation or any change in the composition of the
Board of Directors of the Company (the "Board") or Change of Control (as defined
in Section 1) of the Company), the Company wishes to provide in this Agreement
for the indemnification of and the advancing of expenses to Indemnitee to the
fullest extent (whether partial or complete) permitted by law and as set forth
in this Agreement, and, to the extent insurance is maintained, for the continued
coverage of Indemnitee under the Company's directors' and officers' liability
insurance policies;

                  NOW, THEREFORE, in consideration of these premises and of
Indemnitee's intention to serve the Company directly or, at the Company's
request (and with the Indemnitee's agreement), another enterprise, and,
intending to be legally bound hereby, the parties hereto agree as follows:

                  1.       Certain Definitions. The following terms shall have
the meanings set forth below when such terms are used in this Agreement.

                           (a)      "Beneficial Owner" shall have the meaning
given to such term in Rule 13d-3 under the Exchange Act (as hereinafter
defined); provided, however, that Beneficial Owner shall exclude any Person (as
hereinafter defined) otherwise becoming a Beneficial Owner by reason of the
shareholders of the Company approving a merger of the Company with another
entity.

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                           (b)      "Change of Control" means a change in
control of the Company of a nature that would be required to be reported in
response to Item 6(e) of Schedule 14A of Regulation 14A promulgated under the
Exchange Act, whether or not the Company is in fact required to comply
therewith; provided, that, without limitation, a change in control shall be
deemed to have occurred if:

                                    (i)      any Person or group of Persons,
         other than (A) a trustee or other fiduciary holding securities under an
         employee benefit plan of the Company, or (B) a corporation owned
         directly or indirectly by the stockholders of the Company in
         substantially the same proportions as their ownership of stock of the
         Company is or becomes the Beneficial Owner, directly or indirectly, of
         securities of the Company representing 15% or more of the combined
         voting power,

                                    (ii)     during any period of two
         consecutive years (not including any period prior to the execution of
         this Agreement), individuals who at the beginning of such period
         constitute the Board and any new director whose election by the Board
         or nomination for election by the Company's stockholders was approved
         by a vote of at least 2/3 of the directors then still in office who
         either were directors at the beginning of the period or whose election
         or nomination for election was previously so approved, cease for any
         reason to constitute a majority thereof,

                                    (iii)    the effective date of a merger or
         consolidation of the Company with any other entity, other than a merger
         or consolidation which would result in the Voting Securities (as
         hereinafter defined) of the Company outstanding immediately prior to
         such merger or consolidation continuing to represent (either by
         remaining outstanding or by being converted into Voting Securities of
         the surviving entity) more than fifty-one percent (51%) of the combined
         voting power of the Voting Securities of the surviving entity
         outstanding immediately after such merger or consolidation and with the
         power to elect at least a majority of the board of directors or other
         governing body of such surviving entity,

                                    (iv)     the stockholders of the Company
         approve or authorize a plan of complete liquidation of the Company or
         an agreement for the sale, lease, exchange, transfer or other
         disposition by the Company of (in one transaction or a series of
         transactions) all or substantially all of the Company's assets.

                           (c)      "Exchange Act" shall mean the Securities Act
of 1934, as amended.

                           (d)      "Expenses" means all expenses, liabilities
and losses (including, without limitation, attorneys' and experts' fees and
expenses, costs, obligations, judgments, fines, interest, ERISA excise taxes,
penalties or assessments and amounts paid in settlement) incurred or suffered by
Indemnitee in connection with any Indemnifiable Event (as hereinafter defined)
(including, without limitation, in connection with, investigating, defending,
being a witness in or participating in (including on appeal), or preparing to
defend, be a witness in or participate in, any Proceeding (as hereinafter
defined) relating to any Indemnifiable Event.

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                           (e)      "Independent Legal Counsel" means any
attorney or firm of attorneys, selected in accordance with the provisions of
Section 10, who shall not have otherwise performed services for the Company or
Indemnitee within the last five years (other than with respect to matters
concerning the rights of Indemnitee under this Agreement, or of other
Indemnitees under similar indemnity agreements).

                           (f)      "Person" shall have the meaning set forth in
Sections 13(d) and 14(d) of the Exchange Act; provided, however, that Person
shall exclude (i) the Company, (ii) any trustee or other fiduciary holding
securities under an employee benefit plan of the Company, and (iii) any
corporation owned, directly or indirectly, by the shareholders of the Company in
substantially the same proportions as their ownership of stock of the Company.

                           (g)      "Potential Change of Control" shall be
deemed to have occurred if:

                                    (i)      the Company enters into an
         agreement, the consummation of which would result in the occurrence of
         a Change of Control;

                                    (ii)     any Person, including the Company,
         publicly announces an intention to take or consider taking actions
         which if consummated would constitute a Change of Control;

                                    (iii)    any Person, other than the Company,
         any trustee or other fiduciary holding securities under an employee
         benefit plan of the Company or an corporation owned, directly or
         indirectly, by the stockholders of the Company in substantially the
         same proportions as their ownership of stock of the Company (A) is or
         becomes the Beneficial Owner, (B) discloses directly or indirectly to
         the Company or publicly a plan or intention to become the Beneficial
         Owner, or (C) makes a filing under the Hart-Scott-Rodino Antitrust
         Improvements Act of 1976, as amended, with respect to securities to
         become the Beneficial Owner, directly or indirectly, of securities
         representing 9.9% or more of the combined voting power of the
         outstanding Voting Securities of the Company; or

                                    (iv)     the Board adopts a resolution to
         the effect that, for purposes of this Agreement, a Potential Change of
         Control of the Company has occurred.

                           (h)      "Proceeding" means any threatened, pending
or completed (x) action, suit or proceeding, or (y) inquiry or investigation
that Indemnitee in good faith believes might lead to the institution of an
action, suit or proceeding, in each case, whether instituted by the Company or
any other party and whether civil, criminal, administrative, investigative or
other.

                           (i)      "Voting Securities" means any securities of
the Company which vote generally in the election of directors.

                  2.       Right to Indemnification. The Company shall indemnify
and hold harmless Indemnitee, as soon as practicable but in any event no later
than thirty days after written demand, in connection with any Proceeding to
which Indemnitee is a party or witness or

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in which Indemnitee is otherwise involved, by reason of the fact that Indemnitee
is to become, is or was a director, officer, employee, consultant, agent or
fiduciary of the Company, or is to serve or is or was serving at the request of
the Company as a director, officer, employee, consultant, agent or fiduciary of
another corporation or of a partnership, joint venture, trust or other
enterprise, including, without limitation, service with respect to an employee
benefit plan, or by reason of anything done or not done by Indemnitee in any
such capacity (each such event, occurrence or circumstance in which Indemnitee
is entitled to indemnification pursuant to this Agreement, an "Indemnifiable
Event"), in each case to the fullest extent permitted by applicable law, as the
same exists or may hereafter be amended (but, in the case of any such amendment,
only to the extent that such amendment permits the Company to provide broader
indemnification rights than permitted prior thereto), against all Expenses,
incurred, suffered or paid by Indemnitee in connection therewith, and such
indemnification shall continue after Indemnitee has ceased to be a director,
officer, employee, consultant, agent or fiduciary of the Company and shall inure
to the benefit of Indemnitee's heirs, executors and administrators; provided,
however, that, except as provided in Section 5 hereof with respect to
Proceedings to enforce rights to indemnification, the Company shall indemnify
Indemnitee in connection with a Proceeding (or part thereof) initiated by
Indemnitee only if such Proceeding (or part thereof) was authorized by the
Board.

                  3.       Right to Advancement of Expenses. The right to
indemnification conferred in Section 2 hereof shall include the right to be paid
by the Company (within 2 business days of a request by Indemnitee) the Expenses
incurred or suffered by Indemnitee in connection with defending any Proceeding
for which such right to indemnification is applicable in advance of its final
disposition (an "Advancement of Expenses"); provided, however, that, if, but
only if, the Delaware General Corporation Law ("DGCL") so requires, an
Advancement of Expenses for Indemnitee in his capacity as a director or officer
(and not in any other capacity in which service was or is rendered by
Indemnitee, including, without limitation, service to an employee benefit plan)
shall be made only upon delivery to the Company of an undertaking (an
"Undertaking"), by or on behalf of Indemnitee, to repay all amounts so advanced
if it shall ultimately be determined by final judicial decision from which there
is no further right to appeal (a "Final Adjudication") that Indemnitee is not
entitled to be indemnified for such Expenses under this Agreement or otherwise.

                  4.       Partial Indemnity, Etc. If Indemnitee is entitled
under any provision of this Agreement to indemnification by the Company for some
or a portion of any Expenses incurred or suffered by Indemnitee in connection
with any Proceeding but not, however, for all of the total amount thereof, the
Company shall nevertheless indemnify Indemnitee for the portion thereof to which
Indemnitee is entitled. Moreover, notwithstanding any other provision of this
Agreement, to the extent that Indemnitee has been successful on the merits or
otherwise in defense of any or all Proceedings relating in whole or in part to
an Indemnifiable Event or in defense of any issue or matter therein, including
dismissal without prejudice, Indemnitee shall be indemnified against all
Expenses incurred in connection therewith.

                  5.       Right of Indemnitee to Bring Suit.

                           (a)      If a claim under Section 2, 3 or 4 of this
Agreement is not paid in full by the Company within thirty days after a written
claim has been received by the Company,

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except in the case of a claim for an Advancement of Expenses, in which case the
applicable period shall be two days after a written request has been received by
the Company, Indemnitee may at any time thereafter bring suit against the
Company to recover the unpaid amount of such claim.

                           (b)      The Company shall indemnify and hold
harmless Indemnitee from and against any and all Expenses and, if requested by
Indemnitee, shall (within two business days of any such request) advance funds
to Indemnitee to cover such Expenses, which are incurred by Indemnitee in
connection with any action brought by Indemnitee for (i) indemnification or
advance payment of Expenses by the Company under this Agreement or any other
agreement or Company By-law now or hereafter in effect relating to Indemnifiable
Events and/or (ii) recovery under any directors' and officers' liability
insurance policies maintained by the Company, regardless of whether Indemnitee
ultimately is determined to be entitled to such indemnification, advance expense
payment or insurance recovery, as the case may be.

                           (c)      In any suit brought by Indemnitee to enforce
a right to indemnification hereunder (but not in a suit brought by Indemnitee to
enforce a right to an Advancement of Expenses) it shall be a defense that, and
(ii) in any suit brought by the Company to recover an Advancement of Expenses
pursuant to the terms of an Undertaking the Company shall be entitled to recover
such Expenses upon a Final Adjudication that, Indemnitee has not met any
applicable standard for indemnification required to be met pursuant to the DGCL.
Neither the failure of the Company (including its directors, Independent Legal
Counsel, or its stockholders) to have made a determination prior to the
commencement of such suit that indemnification of Indemnitee is proper in the
circumstances because Indemnitee has met the applicable standard of conduct set
forth in the DGCL, nor an actual determination by the Company (including its
directors, Independent Legal Counsel, or its stockholders) that Indemnitee has
not met such applicable standard of conduct, shall create a presumption that
Indemnitee has not met the applicable standard of conduct or, in the case of
such a suit brought by Indemnitee, be a defense to such suit.

                           (d)      In any suit brought by Indemnitee to enforce
a right to indemnification or to an Advancement of Expenses hereunder, or by the
Company to recover an Advancement of Expenses pursuant to the terms of an
Undertaking, the burden of proving that Indemnitee is not entitled to be
indemnified, or to such Advancement of Expenses, under this Agreement or
otherwise, shall be on the Company.

                  6.       Settlement. The Company shall have no obligation to
indemnify Indemnitee under this Agreement for any amounts paid in settlement of
any Proceeding effected without the Company's prior written consent. The Company
shall not settle any Proceeding in any manner that would impose any fine or any
obligation on Indemnitee without Indemnitee's prior written consent and no
settlement of any Proceeding shall be entered into unless, if applicable, in
Indemnitee's discretion, such settlement includes, as an unconditional term
thereof, the delivery by the claimant or plaintiff in such Proceeding to
Indemnitee of a duly executed written release of Indemnitee from all liability
or obligation in respect of such Proceeding, which release shall be reasonably
satisfactory in form and substance to Indemnitee and Indemnitee's counsel. The
Company shall not unreasonably withhold its consent to any proposed settlement.

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                  7.       Rights Not Exclusive. The rights provided under this
Agreement shall not be deemed exclusive of any other rights which Indemnitee may
be entitled under the Company's By-laws, the Company's Certificate of
Incorporation, the DGCL, any Agreement, any vote of stockholders or of
disinterested directors or otherwise, both as to action in his official capacity
and as to action in any other capacity, and shall continue after Indemnitee
ceases to serve the Company as a director, officer, employee, consultant, agent
or fiduciary (or person named as a prospective director) of the Company. To the
extent that a change in the DGCL (whether by statute or judicial decision)
permits greater indemnification by agreement than would be afforded currently
under the Company's By-laws, the Company's Certificate of Incorporation and this
Agreement, it is the intent of the parties hereto that Indemnitee shall enjoy by
this Agreement the greater benefits so afforded by such change. Unless otherwise
required by law, the Company shall not adopt any amendment to its By-laws or
Certificate of Incorporation the effect of which would be to deny, diminish or
encumber the Indemnitee's rights to indemnification pursuant to this Agreement,
the Company's Certificate of Incorporation, the Company's By-laws, the DGCL or
any other applicable law as applied to any act or failure to act occurring in
whole or in part.

                  8.       Severability. The provisions of this Agreement shall
be severable in the event that any of the provisions hereof (including any
provision within a single section, paragraph or sentence) are held by a court of
competent jurisdiction to be invalid, void or otherwise unenforceable in any
respect, and the validity and enforceability of any such provision in every
other respect and of the remaining provisions hereof shall not be in any way
impaired and shall remain enforceable to the fullest extent permitted by law.

                  9.       Choice of Law. This Agreement shall be governed by
and construed and enforced in accordance with the laws of the State of Delaware,
without giving effect to any conflict of laws, provisions or principles.

                  10.      Change of Control. The Company agrees that if there
is a Change of Control of the Company, then with respect to all matters
thereafter arising concerning the rights of Indemnitee to indemnity payments and
Advancement of Expenses under this Agreement or any other agreement or Company
By-law now or hereafter in effect relating to Indemnifiable Events, the Company
shall seek legal advice only from Independent Legal Counsel selected by
Indemnitee and approved by the Company (which approval shall not be unreasonably
withheld). Such counsel, among other things, shall render its written opinion to
the Company and Indemnitee as to whether and to what extent the Indemnitee would
be permitted to be indemnified under applicable law. The Company agrees to pay
the reasonable fees of the Independent Legal Counsel referred to above and to
indemnify fully such counsel against any and all expenses (including attorneys'
fees), claims, liabilities and damages arising out of or relating to this
Agreement or its engagement pursuant thereto.

                  11.      Establishment of Trust. In the event of a Potential
Change in Control, the Company may create a trust for the benefit of the
Indemnitee (either alone or together with one or more other indemnitees) and
from time to time fund such trust in such amounts as the Board may determine to
satisfy Expenses reasonably anticipated to be incurred in connection with
investigating, preparing for and defending any claim relating to an
Indemnifiable Event, and all judgments, fees, fines, penalties and settlement
amounts of all claims relating to an Indemnifiable Event from time to time paid
or claimed, reasonably anticipated or proposed to be

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paid. The terms of any trust established pursuant hereto shall provide that upon
a Change in Control (i) the trust shall not be revoked or the principal thereof
invaded, without the written consent of the Indemnitee, (ii) the trustee shall
advance, within ten business days of a request by the Indemnitee, all Expenses
to the Indemnitee, (iii) the trustee shall promptly pay to the Indemnitee all
amounts for which the Indemnitee shall be entitled to indemnification pursuant
to this Agreement or otherwise, and (iv) all unexpended funds in such trust
shall revert to the Company upon a final determination by a court of competent
jurisdiction, as the case may be, that the Indemnitee has been fully indemnified
under the terms of this Agreement. The trustee shall be a person or entity
satisfactory to the Indemnitee. Nothing in this Section 11 shall relieve the
Company of any of its obligations under this Agreement.

                  12.      Burden of Proof. In connection with any determination
as to whether Indemnitee is entitled to be indemnified hereunder the burden of
proof shall be on the Company to establish that Indemnitee is not so entitled.

                  13.      No Presumptions. For purposes of this Agreement, the
termination of any Proceeding, by judgment, order, settlement (whether with or
without court approval) or conviction, or upon a plea of nolo contendere, or its
equivalent, shall not create a presumption that Indemnitee did not meet any
particular standard of conduct or have any particular belief or that a court has
determined that indemnification is not permitted by applicable law.

                  14.      Liability Insurance. The Company is maintaining
(pursuant to a policy or policies, true and complete copies of which have been
made available to Indemnitee), and shall maintain, an insurance policy or
policies providing directors' and officers' liability insurance. Indemnitee
shall be covered by such policy or policies, for proposing to become, serving as
or having served as a director, officer, employee, consultant, agent or
fiduciary (or person named as a prospective director) of the Company, or, at the
request of the Company, of another corporation or of a partnership, joint
venture, trust or other enterprise, to the maximum extent of the coverage
available for any person in such capacity. The Company shall maintain the
Company's insurance policy providing directors' and officers' liability
insurance that is in place as of the date hereof for a period from the date
hereof until six years after the last date on which Indemnitee ceases to be a
director, officer, employee, consultant, agent or fiduciary of the Company (or
person named as a prospective director) or, at the request of the Company, of
another corporation, partnership, joint venture, employee benefit plan, trust or
other enterprise; provided, however, that the Company may substitute therefor
policies of substantially similar coverage and amounts containing material terms
no less advantageous to the Indemnitee.

                  15.      Subrogation. In the event of any payment under this
Agreement, the Company shall be subrogated to the extent of such payment to all
of the rights of recovery of Indemnitee, who shall execute all papers required
and take all action necessary to secure such rights, including execution of such
documents as are necessary to enable the Company to bring suit to enforce such
rights.

                  16.      Period of Limitations. No legal action shall be
brought and no cause of action shall be asserted by or in the right of the
Company against Indemnitee, Indemnitee's spouse, heirs, executors or personal or
legal representatives after the expiration of two years from the date of accrual
of such cause of action, and any claim or cause of action of the Company

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shall be extinguished and deemed released unless asserted by the timely filing
of a legal action within such two-year period; provided, however, that if any
shorter period of limitations is otherwise applicable to any such cause of
action such shorter period shall govern.

                  17.      Successor and Assignments; Effectiveness of
Agreement. This Agreement shall be (i) binding upon all successors and assigns
of the Company (including any transferee of all or substantially all of its
assets and any successor by merger or otherwise by operation of law) and (ii)
shall be binding on and inure to the benefit of the heirs, personal
representatives and estate of Indemnitee. This Agreement shall continue in
effect regardless of whether Indemnitee becomes a director, officer, employee,
consultant, agent or fiduciary (or person named as a prospective director) of
the Company, or continues to serve as a director, officer, employee, consultant,
agent or fiduciary (or person named as a prospective director) of the Company or
of any other corporation, partnership, joint venture or other enterprise at the
request of the Company.

                  18.      Amendment. No amendment, modification, termination or
cancellation of this Agreement shall be effective unless made in a writing
signed by each of the parties hereto.

                  19.      Notices. All notices, requests, demands and other
communications under this Agreement shall be in writing and shall be deemed to
have been duly given (a) if delivered by hand and receipted for by the party to
whom said notice or other communication shall have been directed, or (b) mailed
by certified or registered mail with postage prepaid, on the third business day
after the date on which it is so mailed:

                           (a)      If to Indemnitee:

                                    --------------------
                                    --------------------
                                    --------------------

or such other address as Indemnitee shall provide to the Company.

                           (b)      If to the Company to:

                                    Aderis Pharmaceuticals, Inc.
                                    85 Main Street
                                    Hopkinton, MA 01748
                                    Attention: Chief Executive Officer

or such other address as may have been furnished to Indemnitee by the Company.

               [Remainder of this page intentionally left blank.]

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                  IN WITNESS WHEREOF, the Company and Indemnitee have executed
this Agreement as of the day and year first above written.

                                                 ADERIS PHARMACEUTICALS, INC.,
                                                 a Delaware corporation

                                                 By:____________________________
                                                 Name:__________________________
                                                 Title:_________________________

                                                 -------------------------------

                                        9<PAGE>

                                                                    EXHIBIT 10.2

                          DISCOVERY THERAPEUTICS, INC.

                             1995 STOCK OPTION PLAN

                           ADOPTED AND APPROVED BY THE

                         STOCKHOLDERS ON MARCH 29, 1995

1.       PURPOSES.

         (a)      The purpose of the Plan is to provide a means by which
selected Employees and Directors of and Consultants to the Company, and its
Affiliates, may be given an opportunity to purchase stock of the Company.

         (b)      The Company, by means of the Plan, seeks to retain the
services of persons who are now Employees or Directors of or Consultants to the
Company or its Affiliates, to secure and retain the services of new Employees,
Directors and Consultants, and to provide incentives for such persons to exert
maximum efforts for the success of the Company and its Affiliates.

         (c)      The Company intends that the Options issued under the Plan
shall, in the discretion of the Board or any Committee to which responsibility
for administration of the Plan has been delegated pursuant to subsection 3(c),
be either Incentive Stock Options or Nonstatutory Stock Options. All Options
shall be separately designated Incentive Stock Options or Nonstatutory Stock
Options at the time of grant, and in such form as issued pursuant to Section 6,
and a separate certificate or certificates will be issued for shares purchased
on exercise of each type of Option.

2.       DEFINITIONS.

         (a)      "Affiliate" means any parent corporation or subsidiary
corporation, whether now or hereafter existing, as those terms are defined in
Sections 424(e) and (f) respectively, of the Code.

         (b)      "Board" means the Board of Directors of the Company.

         (c)      "Code" means the Internal Revenue Code of 1986, as amended.

         (d)      "Committee" means a Committee appointed by the Board in
accordance with subsection 3(c) of the Plan.

         (e)      "Company" means Discovery Therapeutics, Inc., a Delaware
corporation.

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         (f)      "Consultant" means any person, including any advisor, engaged
by the Company or an Affiliate to render consulting services and who is
compensated for such services, provided that the term "Consultant" shall not
include Directors who are paid only a director's fee by the Company or who are
not compensated by the Company for their services as Directors.

         (g)      "Continuous Status as an Employee, Director or Consultant"
means the employment or relationship as a Director or Consultant is not
interrupted or terminated. The Board, in its sole discretion, may determine
whether Continuous Status as an Employee, Director or Consultant shall be
considered interrupted in the case of: (i) any leave of absence approved by the
Board, including sick leave, military leave, or any other personal leave; or
(ii) transfers between locations of the Company or between the Company,
Affiliates or their successors.

         (h)      "Covered Employee" means the Chief Executive Officer and the
four (4) other highest compensated officers of the Company.

         (i)      "Director" means a member of the Board.

         (j)      "Disinterested Person" means a Director who either (i) was not
during the one year prior to service as an administrator of the Plan granted or
awarded equity securities pursuant to the Plan or any other plan of the Company
or any of its affiliates entitling the participants therein to acquire equity
securities of the Company or any of its affiliates except as permitted by Rule
16b-3(c)(2)(i); or (ii) is otherwise considered to be a "disinterested person"
in accordance with Rule 16b-3(c)(2)(i), or any other applicable rules,
regulations or interpretations of the Securities and Exchange Commission.

         (k)      "Employee" means any person, including Officers and Directors,
employed by the Company or any Affiliate of the Company. Neither service as a
Director nor payment of a director's fee by the Company shall be sufficient to
constitute "employment" by the Company.

         (l)      "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

         (m)      "Fair Market Value" means the value of the common stock as
determined in good faith by the Board.

         (n)      "Incentive Stock Option" means an Option intended to qualify
as an incentive stock option within the meaning of Section 422 of the Code and
the regulations promulgated thereunder.

         (o)      "Nonsatutory Stock Option" means an Option not intended to
qualify as an Incentive Stock Option.

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         (p)      "Officer" means a person who is an officer of the Company
within the meaning of Section 16 of the Exchange Act and the rules and
regulations promulgated thereunder.

         (q)      "Option" means a stock option granted pursuant to the Plan.

         (r)      "Option Agreement" means a written agreement between the
Company and an Optionee evidencing the terms and conditions of an individual
Option grant. Each Option Agreement shall be subject to the terms and conditions
of the Plan.

         (s)      "Optionee" means an Employee, Director or Consultant who holds
an outstanding Option.

         (t)      "Outside Director" means a Director who either (i) is not a
current employee of the Company or an "affiliated corporation" (as defined in
the Treasury regulations promulgated under Section 162(m) of the Code), is not a
former employee of the Company or an affiliated corporation receiving
compensation for prior services (other than benefits under a tax qualified
pension plan), was not an officer of the Company or an affiliated corporation at
any time, and is not currently receiving compensation for personal services in
any capacity other than as a Director, or (ii) is otherwise considered an
"outside director" for purposes of Section 162(m) of the Code.

         (u)      "Plan" means this Discovery Therapeutics, Inc. Stock Option
Plan.

         (v)      "Rule 16b-3" means Rule 16b-3 of the Exchange Act or any
successor to Rule 16b-3, as in effect when discretion is being exercised with
respect to the Plan.

3.       ADMINISTRATION.

         (a)      The Plan shall be administered by the Board unless and until
the Board delegates administration to a Committee, as provided in subsection
3(c).

         (b)      The Board shall have the power, subject to, and within the
limitations of, the express provisions of the Plan:

                  (1)      To determine from time to time which of the persons
eligible under the Plan shall be granted Options; when and how each Option shall
be granted; whether an Option will be an Incentive Stock Option or a
Nonstatutory Stock Option; the provisions of each Option granted (which need not
be identical), including the time or times such Option may be exercised in whole
or in part; and the number of shares for which an Option shall be granted to
each such person.

                                       3

<PAGE>

                  (2)      To construe and interpret the Plan and Options
granted under it, and to establish, amend and revoke rules and regulations for
its administration. The Board, in the exercise of this power, may correct any
defect, omission or inconsistency in the Plan or in any Option Agreement, in a
manner and to the extent it shall deem necessary or expedient to make the Plan
fully effective.

                  (3)      To amend the Plan as provided in Section 11.

                  (4)      Generally, to exercise such powers and to perform
such acts as the Board deems necessary or expedient to promote the best
interests of the Company.

         (c)      Board may delegate administration of the Plan to a committee
composed of not fewer than two (2) members (the "Committee"), all of the members
of which Committee shall be Disinterested Persons and may also be, in the
discretion of the Board, Outside Directors. If administration is delegated to a
Committee, the Committee shall have, in connection with the administration of
the Plan, the powers theretofore possessed by the Board (and references in this
Plan to the Board shall thereafter be to the Committee), subject, however, to
such resolutions, not inconsistent with the provisions of the Plan, as may be
adopted from time to time by the Board. The Board may abolish the Committee at
any time and revest in the Board the administration of the Plan. Additionally,
prior to the date of the first registration of an equity security of the Company
under Section 12 of the Exchange Act, and notwithstanding anything to the
contrary contained herein, the Board may delegate administration of the Plan to
any person or persons and the term "Committee" shall apply to any person or
persons to whom such authority has been delegated. Notwithstanding anything in
this Section 3 to the contrary, the Board or the Committee may delegate to a
committee of one or more members of the Board the authority to grant Options to
eligible persons who (1) are not then subject to Section 16 of the Exchange Act
and/or (2) are either (i) not then Covered Employees and are not expected to be
Covered Employees at the time of recognition of income resulting from such
Option, or (ii) not persons with respect to whom the Company wishes to comply
with Section 162(m) of the Code.

         (d)      Any requirement that an administrator of the Plan be a
Disinterested Person shall not apply (i) prior to the date of the first
registration of an equity security of the Company under Section 12 of the
Exchange Act, or (ii) if the Board or the Committee expressly declares that such
requirement shall not apply. Any Disinterested Person shall otherwise comply
with the requirements of Rule 16b-3.

                                       4

<PAGE>

4.       SHARES SUBJECT TO THE PLAN.

         (a)      Subject to the provisions of Section 10 relating to
adjustments upon changes in stock, the stock that may be sold pursuant to
Options shall not exceed in the aggregate Five Hundred Thousand (500,000) shares
of the Company's common stock. If any Option shall for any reason expire or
otherwise terminate, in whole or in part, without having been exercised in full,
the stock not purchased under such Option shall revert to and again become
available for issuance under the Plan.

         (b)      The stock subject to the Plan may be unissued shares or
reacquired shares, bought on the market or otherwise.

5.       ELIGIBILITY.

         (a)      Incentive Stock Options may be granted only to Employees.
Nonstatutory Stock Options may be granted only to Employees, Directors or
Consultants.

         (b)      A Director shall in no event be eligible for the benefits of
the Plan unless at the time discretion is exercised in the selection of the
Director as a person to whom Options may be granted, or in the determination of
the number of shares which may be covered by Options granted to the Director:
(i) the Board has delegated its discretionary authority over the Plan to a
Committee which consists solely of Disinterested Persons; or (ii) the Plan
otherwise complies with the requirements of Rule 16b-3. The Board shall
otherwise comply with the requirements of Rule 16b-3. This subsection 5(b) shall
not apply (i) prior to the date of the first registration of an equity security
of the Company under Section 12 of the Exchange Act, or (ii) if the Board or
Committee expressly declares that it shall not apply.

         (c)      No person shall be eligible for the grant of an Incentive
Stock Option if, at the time of grant, such person owns (or is deemed to own
pursuant to Section 424(d) of the Code) stock possessing more than ten percent
(10%) of the total combined voting power of all classes of stock of the Company
or of any of its Affiliates unless the exercise price of such Option is at least
one hundred ten percent (110%) of the Fair Market Value of such stock at the
date of grant and the Option is not exercisable after the expiration of the five
(5) years from the date of grant.

                                       5

<PAGE>

6.       OPTION PROVISIONS.

         Each Option shall be in such form and shall contain such terms and
conditions as the Board shall deem appropriate. The provisions of separate
Options need not be identical, but each Option shall include (through
incorporation of provisions hereof by reference in the Option or otherwise) the
substance of each of the following provisions:

         (a)      Term. No Option shall be exercisable after the expiration of
ten (10) years from the date it was granted.

         (b)      Price. The exercise price of each Incentive Stock Option shall
be not less than one hundred percent (100%) of the Fair Market Value of the
stock subject to the Option on the date the Option is granted. The exercise
price of each Nonstatutory Stock Option shall be not less than eighty-five
percent (85%) of the Fair Market Value of the stock subject to the Option on the
date the Option is granted.

         (c)      Consideration. The purchase price of stock acquired pursuant
to an Option shall be paid, to the extent permitted by applicable statues and
regulations, either (i) in cash at the time the Option is exercised, or (ii) at
the discretion of the Board or the Committee, either at the time of the grant or
exercise of the Option, (A) by delivery to the Company of other common stock of
the Company, (B) according to a deferred payment or other arrangement (which may
include, without limiting the generality of the foregoing, the use of other
common stock of the Company) with the person to whom the Option is granted or to
whom the Option is transferred pursuant to subsection 6(d), or (C) in any other
form of legal consideration that may be acceptable to the Board.

         In the case of any deferred payment arrangement, interest shall be
payable at least annually and shall be charged at the minimum rate of interest
necessary to avoid the treatment as interest, under any applicable provisions of
the Code, of any amounts other than amounts stated to be interest under the
deferred payment arrangement.

         (d)      Transferability. An Option shall not be transferable except by
will or by the laws of descent and distribution, and shall be exercisable during
the lifetime of the person to whom the Option is granted only by such person. A
Nonstatutory Stock Option shall not be transferable except by will or by the
laws of descent and distribution or pursuant to a qualified domestic relations
order satisfying the requirements of Rule 16b-3 and the rules thereunder (a
"QDRO"), and shall be exercisable during the lifetime of the person to whom the
Option is

                                       6

<PAGE>

granted only by such person or any transferee pursuant to a QDRO. The person to
whom the Option is granted may, by delivering written notice to the Company, in
a form satisfactory to the Company, designate a third party who, in the event of
the death of the Optionee, shall thereafter be entitled to exercise the Option.

         (e)      Vesting. The total number of shares of stock subject to an
Option may, but need not, be allotted in periodic installments (which may, but
need not, be equal). The Option Agreement may provide that from time to time
during each of such installment periods, the Option may become exercisable
("vest") with respect to some or all of the shares allotted to that period and
may be exercised with respect to some or all of the shares allotted to such
period and/or any prior period as to which the Option became vested but was not
fully exercised. The Option may be subject to such other terms and conditions on
the time or times when it may be exercised (which may be based on performance or
other criteria) as the Board may deem appropriate. The vesting provisions of
individual Options may vary but in each case will provide for vesting of at
least twenty percent (20%) per year of the total number of shares subject to the
Option. The provisions of this subsection 6(e) are subject to any Option
provisions governing the minimum number of shares as to which an Option may be
exercised.

         (f)      Securities Law Compliance. The Company may require any
Optionee, or any person to whom an Option is transferred under subsection 6(d),
as a condition of exercising any such Option, (1) to give written assurances
satisfactory to the Company as to the Optionee's knowledge and experience in
financial and business matters and/or to employ a purchaser representative
reasonably satisfactory to the Company who is knowledgeable and experienced in
financial and business matters, and that he or she is capable of evaluating,
alone or together with the purchaser representative, the merits and risks of
exercising the Option; and (2) to give written assurances satisfactory to the
Company stating that such person is acquiring the stock subject to the Option
for such person's own account and not with any present intention of selling or
otherwise distributing the stock. The foregoing requirements, and any assurances
given pursuant to such requirements, shall be inoperative if (i) the issuance of
the shares upon the exercise of the Option has been registered under a then
currently effective registration statement under the Securities Act of 1933, as
amended (the "Securities Act"), or (ii) as to any particular requirement, a
determination is made by counsel for the Company that such requirement need not
be met in the circumstances under the then applicable securities laws. The
Company may,

                                       7

<PAGE>

upon advice of counsel to the Company, place legends on stock certificates
issued under the Plan as such counsel deems necessary or appropriate in order to
comply with applicable securities laws, including, but not limited to, legends
restricting the transfer of the stock.

         (g)      Termination of Employment or Relationship as a Director or
Consultant. In the event an Optionee's Continuous Status as an Employee,
Director or Consultant terminates (other than upon the Optionee's death or
disability), the Optionee may exercise his or her Option (to the extent that the
Optionee was entitled to exercise it at the date of termination) but only within
such period of time ending on the earlier of (i) the date three (3) months after
the termination of the Optionee's Continuous Status as an Employee, Director or
Consultant (or such longer or shorter period specified in the Option Agreement),
or (ii) the expiration of the term of the Option as set forth in the Option
Agreement. If, after termination, the Optionee does not exercise his or her
Option within the time specified in the Option Agreement, the Option shall
terminate, and the shares covered by such Option shall revert to and again
become available for issuance under the Plan.

         (h)      Disability of Optionee. In the event an Optionee's Continuous
Status as an Employee, Director or Consultant terminates as a result of the
Optionee's disability, the Optionee may exercise his or her Option (to the
extent that the Optionee was entitled to exercise it at the date of
termination), but only within such period of time ending on the earlier of (i)
the date twelve (12) months following such termination (or such longer or
shorter period specified in the Option Agreement), or (ii) the expiration of the
term of the Option as set forth in the Option Agreement. If, at the date of
termination, the Optionee is not entitled to exercise his or her entire Option,
the shares covered by the unexercisable portion of the Option shall revert to
and again become available for issuance under the Plan. If, after termination,
the Optionee does not exercise his or her Option within the time specified
herein, the Option shall terminate, and the shares covered by such Option shall
revert to and again become available for issuance under the Plan.

         (i)      Death of Optionee. In the event of the death of an Optionee
during, or within a period specified in the Option after the termination of, the
Optionee's Continuous Status as an Employee, Director or Consultant, the Option
may be exercised (to the extent the Optionee was entitled to exercise the Option
at the date of death) by the Optionee's estate, by a person who acquired the
right to exercise the Option by bequest or inheritance or by a person designated
to

                                       8

<PAGE>

exercise the Option upon the Optionee's death pursuant to subsection 6(d), but
only within the period ending on the earlier of (i) the date eighteen (18)
months following the date of death (or such longer or shorter period specified
in the Option Agreement), or (ii) the expiration of the term of such Option as
set forth in the Option Agreement. If, at the time of death, the Optionee was
not entitled to exercise his or her entire Option, the shares covered by the
unexercisable portion of the Option shall revert to and again become available
for issuance under the Plan. If, after death, the Option is not exercised within
the time specified herein, the Option shall terminate, and the shares covered by
such Option shall revert to and again become available for issuance under the
Plan.

         (j)      Early Exercise. The Option may, but need not, include a
provision whereby the Optionee may elect at any time while an Employee, Director
or Consultant to exercise the Option as to any part or all of the shares subject
to the Option prior to the full vesting of the Option. Any unvested shares so
purchased may be subject to a repurchase right in favor of the Company or to any
other restriction the Board determines to be appropriate.

         (k)      Withholding. To the extent provided by the terms of an Option
Agreement, the Optionee may satisfy any federal, state or local tax withholding
obligation relating to the exercise of such Option by any of the following means
or by a combination of such means: (1) tendering a cash payment; (2) authorizing
the Company to withhold shares from the shares of the common stock otherwise
issuable to the participant as a result of the exercise of the Option; or (3)
delivering to the Company owned and unencumbered shares of the common stock of
the Company.

7.       COVENANTS OF THE COMPANY.

         (a)      During the terms of the Options, the Company shall keep
available at all times the number of shares of stock required to satisfy such
Options.

         (b)      The Company shall seek to obtain from each regulatory
commission or agency having jurisdiction over the Plan such authority as may be
required to issue and sell shares of stock upon exercise of the options;
provided, however, that this undertaking shall not require the Company to
register under Securities Act either the Plan, any Option or any stock issued or
issuable pursuant to any such Option. If, after reasonable efforts, the Company
is unable to obtain from any such regulatory commission or agency the authority
which counsel for the

                                       9

<PAGE>

Company deems necessary for the lawful issuance and sale of stock under the
Plan, the Company shall be relieved from any liability for failure to issue and
sell stock upon exercise of such Options unless and until such authority is
obtained.

8.       USE OF PROCEEDS FROM STOCK.

         Proceeds from the sale of stock pursuant to Options shall constitute
general funds of the Company.

9.       MISCELLANEOUS.

         (a)      The Board shall have the power to accelerate the time at which
an Option may first be exercised or the time during which an Option or any part
thereof will vest pursuant to subsection 6(e), notwithstanding the provisions in
the Option stating the time at which it may first be exercised or the time
during which it will vest.

         (b)      Neither an Optionee nor any person to whom an Option is
transferred under subsection 6(d) shall be deemed to be the holder of, or to
have any of the rights of a holder with respect to, any shares subject to such
Option unless and until such person has satisfied all requirements for exercise
of the Option pursuant to its terms.

         (c)      Nothing in the Plan or any instrument executed or Option
granted pursuant thereto shall confer upon any Employee, Director, Consultant or
Optionee any right to continue in the employ of the Company or any Affiliate (or
to continue acting as a Director or Consultant) or shall affect the right of the
Company or any Affiliate to terminate the employment or relationship as a
Director or Consultant of any Employee, Director, Consultant or Optionee with or
without cause.

         (d)      To the extent that the aggregate Fair Market Value (determined
at the time of grant) of stock with respect to which Incentive Stock Options
granted after 1986 are exercisable for the first time by any Optionee during any
calendar year under all plans of the Company and its Affiliates exceeds one
hundred thousand dollars ($100,000), the Options or portions thereof which
exceed such limit (according to the order in which they were granted) shall be
treated as Nonstatutory Stock Options.

         (e)      The Board or the Committee shall have the authority to effect,
at any time and from time to time (i) the repricing of any outstanding Options
under the Plan and/or (ii) with the

                                       10

<PAGE>

consent of the affected holders of Options, the cancellation of any outstanding
Options and the grant in substitution therefor of new Options under the Plan
covering the same or different numbers of shares of Common Stock, but having an
exercise price per share not less than eighty-five percent (85%) of the Fair
Market Value (in the case of an Incentive Stock Option one hundred percent
(100%) of the Fair Market Value unless the holder thereof is a ten percent (10%)
stockholder (as defined in subsection 5(c)), in which case not less than one
hundred and ten percent (110%) of the Fair Market Value) per share of Common
Stock on the new grant date.

10.      ADJUSTMENTS UPON CHANGES IN STOCK.

         (a)      If any change is made in the stock subject to the Plan, or
subject to any Option (through merger, consolidation, reorganization,
recapitalization, stock dividend, dividend in property other than cash, stock
split, liquidating dividend, combination of shares, exchange of shares, change
in corporate structure or otherwise), the Plan and outstanding Options will be
appropriately adjusted in the class(es) and maximum number of shares subject to
the Plan and the class(es) and number of shares and price per share of stock
subject to outstanding Options.

         (b)      In the event of: (1) a dissolution, liquidation or sale of
substantially all of the assets of the Company; (2) a merger or consolidation in
which the Company is not the surviving corporation; or (3) a reverse merger in
which the Company is the surviving corporation but the shares of the Company's
common stock outstanding immediately preceding the merger are converted by
virtue of the merger into other property, whether in the form of securities,
cash or otherwise, then to the extent permitted by applicable law: (i) any
surviving corporation shall assume any Options outstanding under the Plan or
shall substitute similar Options for those outstanding under the Plan, or (ii)
such Options shall continue in full force and effect. In the event any surviving
corporation refuses to assume or continue such Options, or to substitute similar
options for those outstanding under the Plan, then, with respect to Options held
by persons then performing services as Employees, Directors or Consultants, the
time during which such Options may be exercised shall be accelerated and the
Options terminated if not exercised prior to such event.

                                       11

<PAGE>

11.      AMENDMENT OF THE PLAN.

         (a)      The Board at any time, and from time to time, may amend the
Plan. However, except as provided in Section 10 relating to adjustments upon
changes in stock, no amendment shall be effective unless approved by the
stockholders of the company within twelve (12) months before or after the
adoption of the amendment, where the amendment will:

                  (1)      Increase the number of shares reserved for Options
under the Plan;

                  (2)      Modify the requirements as to eligibility for
participation in the Plan (to the extent such modification requires stockholder
approval in order for the Plan to satisfy the requirements of Section 422 of the
Code); or

                  (3)      Modify the Plan in any other way if such modification
requires stockholder approval in order for the Plan to satisfy the requirements
of Section 422 of the Code or to comply with the requirements of Rule 16b-3.

         (b)      The Board may in its sole discretion submit any other
amendment to the Plan for stockholder approval, including, but not limited to,
amendments to the Plan intended to satisfy the requirements of Section 162(m) of
the Code and the regulations promulgated thereunder regarding the exclusion of
performance-based compensation from the limit on corporate deductibility of
compensation paid to certain executive officers.

         (c)      It is expressly contemplated that the Board may amend the Plan
in any respect the Board deems necessary or advisable to provide Optionees with
the maximum benefits provided or to be provided under the provisions of the Code
and the regulations promulgated thereunder relating to Incentive Stock Options
and/or to bring the Plan and/or Incentive Stock Options granted under it into
compliance therewith.

         (d)      Rights and obligations under any Option granted before
amendment of the Plan shall not be altered or impaired by any amendment of the
Plan unless (i) the Company requests the consent of the person to whom the
Option was granted and (ii) such person consents in writing.

12.      TERMINATION OR SUSPENSION OF THE PLAN.

         (a)      The Board may suspend or terminate the Plan at any time.
Unless sooner terminated, the Plan shall terminate on March 28, 2005, which
shall be within ten (10) years from the date the Plan is adopted by the Board or
approved by the stockholders of the Company,

                                       12

<PAGE>

whichever is earlier. No Options may be granted under the Plan while the Plan is
suspended or after it is terminated.

         (b)      Rights and obligations under any Option granted while the Plan
is in effect shall not be altered or impaired by suspension or termination of
the Plan, except with the consent of the person to whom the Option was granted.

13.      EFFECTIVE DATE OF PLAN.

         The Plan shall become effective as determined by the Board, but no
Options granted under the Plan shall be exercised unless and until the Plan has
been approved by the stockholders of the Company, which approval shall be within
twelve (12) months before or after the date the Plan is adopted by the Board.

                                       13

<PAGE>

                             FIRST AMENDMENT TO THE
                            1995 STOCK OPTION PLAN OF
                          DISCOVERY THERAPEUTICS, INC.

         This First Amendment (this "Amendment") to the Discovery Therapeutics,
Inc. 1995 Stock Option Plan, (the "Plan") of Discovery Therapeutics, Inc. is
hereby adopted by Discovery Therapeutics, Inc., a Delaware corporation (the
"Company"), effective as of June 7, 1999.

                                    RECITALS

         A.       The Plan was originally adopted by the Board of Directors and
stockholders of the Company on March 29, 1995.

         B.       Effective as of June 7, 1999, the Board of Directors of the
Company approved this Amendment.

                                  THE AMENDMENT

         1.       Shares Subject to the Plan. Section 4(a) of the Plan is hereby
amended in its entirety to read as follows:

         "(a)     Subject to the provisions of Section 10 relating to
adjustments upon changes in stock, the stock that may be sold pursuant to
Options shall not exceed in the aggregate One Million (1,000,000) shares of the
Company's common stock. If any Option shall for any reason expire or otherwise
terminate, in whole or in part, without having been exercised in full, the stock
not purchased under such Option shall revert to and again become available for
issuance under the Plan."

                                    * * * * *

<PAGE>

         The undersigned, Kenneth L. Rice, Jr., Secretary of the Company, hereby
certifies that the Board of Directors approved this Amendment.

         Executed this 3rd day of January 3, 2002.

                                            DISCOVERY THERAPEUTICS, INC.,
                                            a Delaware corporation

                                            By: /s/ Kenneth L. Rice, Jr.
                                                -------------------------
                                                Kenneth L. Rice, Jr.
                                                Secretary

<PAGE>

                             SECOND AMENDMENT TO THE
                            1995 STOCK OPTION PLAN OF
                          DISCOVERY THERAPEUTICS, INC.

         This Second Amendment (this "Amendment") to the Discovery Therapeutics,
Inc. 1995 Stock Option Plan, as amended on June 7, 1999 (the "Plan") of
Discovery Therapeutics, Inc. is hereby adopted by Discovery Therapeutics, Inc.,
a Delaware corporation (the "Company"), effective as of August 10, 2001.

                                    RECITALS

         A.       The Plan was originally adopted by the Board of Directors and
stockholders of the Company on March 29, 1995.

         B.       The Plan was amended on June 7, 1999 to raise the number of
shares of the Company's common stock issuable under the Plan to One Million
(1,000,000) shares.

         C.       Effective as of August 10, 2001, the Board of Directors of the
Company approved this Amendment.

                                  THE AMENDMENT

         1.       Shares Subject to the Plan. Section 4(a) of the Plan is hereby
amended in its entirety to read as follows:

                  "(a)     Subject to the provisions of Section 10 relating to
         adjustments upon changes in stock, the stock that may be sold pursuant
         to Options shall not exceed in the aggregate One Million, Five Hundred
         Thousand (1,500,000) shares of the Company's common stock. If any
         Option shall for any reason expire or otherwise terminate, in whole or
         in part, without having been exercised in full, the stock not purchased
         under such Option shall revert to and again become available for
         issuance under the Plan."

                                    * * * * *

<PAGE>

         The undersigned, Kenneth L. Rice, Jr., Secretary of the Company, hereby
certifies that the Board of Directors approved this Amendment.

         Executed this 3rd day of January, 2002.

                                         DISCOVERY THERAPEUTICS, INC.,
                                         a Delaware corporation

                                         By: /s/ Kenneth L. Rice, Jr.
                                             -----------------------------
                                             Kenneth L. Rice, Jr.
                                             Secretary

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