Document:

exv4w1

Exhibit 4.1

THE TJX COMPANIES, INC.,

as Issuer

and

U.S. Bank National Association,

as Trustee

FIRST SUPPLEMENTAL INDENTURE

Dated as of April 7, 2009

to the Indenture dated as of April 2, 2009

6.950% Notes due 2019

 

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 
	 	 	 	 	Page
	ARTICLE 1
	APPLICATION OF SUPPLEMENTAL INDENTURE
	 
	 	 	 	 	 	 
	Section 1.01.

	 	Application of First Supplemental Indenture	 	 	2	 
	 
	 	 	 	 	 	 
	ARTICLE 2
	DEFINITIONS
	 
	 	 	 	 	 	 
	Section 2.01.

	 	Certain Terms Defined in the Indenture
	 	 	2	 
	Section 2.02.

	 	Definitions
	 	 	2	 
	 
	 	 	 	 	 	 
	ARTICLE 3
	FORM AND TERMS OF THE NOTES
	 
	 	 	 	 	 	 
	Section 3.01.

	 	Form and Dating
	 	 	7	 
	Section 3.02.

	 	Terms of the Notes
	 	 	8	 
	Section 3.03.

	 	Optional Redemption
	 	 	8	 
	Section 3.04.

	 	Repurchase of Notes upon a Change of Control
	 	 	9	 
	Section 3.05.

	 	Certain Interest Payments
	 	 	10	 
	 
	 	 	 	 	 	 
	ARTICLE 4
	CERTAIN COVENANTS
	 
	 	 	 	 	 	 
	Section 4.01.

	 	Restrictions on Secured Debt
	 	 	11	 
	Section 4.02.

	 	Restrictions on Sale and Leaseback Transactions
	 	 	12	 
	Section 4.03.

	 	Exempted Debt
	 	 	13	 
	Section 4.04.

	 	Limitations Upon Permitting Restricted Subsidiaries to become
Non-Restricted Subsidiaries and Non-Restricted Subsidiaries to become
Restricted
Subsidiaries
	 	 	13	 
	 
	 	 	 	 	 	 
	ARTICLE 5
	MISCELLANEOUS
	 
	 	 	 	 	 	 
	Section 5.01.

	 	Trust Indenture Act Controls
	 	 	14	 
	Section 5.02.

	 	New York Law to Govern
	 	 	14	 
	Section 5.03.

	 	Counterparts
	 	 	14	 
	Section 5.04.

	 	Severability
	 	 	14	 
	Section 5.05.

	 	Ratification
	 	 	14	 
	Section 5.06.

	 	Effectiveness
	 	 	14	 
	Section 5.07.

	 	Trustee Makes No Representation
	 	 	14	 

 i

 

 

	 	 	 
	 

	 	Page
	EXHIBIT A — Form of 6.950% Note due 2019

	 	A-1

 ii

 

 

FIRST SUPPLEMENTAL INDENTURE

          FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), dated as of April 7, 2009,
between The TJX Companies, Inc., a Delaware corporation (the “Company”), and U.S. Bank National
Association, as Trustee (the “Trustee”).

RECITALS OF THE COMPANY

          WHEREAS, the Company and the Trustee executed and delivered an Indenture, dated as of April 2,
2009 (the “Base Indenture,” and together with the First Supplemental Indenture, the “Indenture”),
to provide for the issuance by the Company from time to time of Securities to be issued in one or
mores series as provided in the Indenture;

          WHEREAS, Section 9.1 of the Base Indenture provides, among other things, that the Company and
the Trustee may enter into indentures supplemental to the Base Indenture, without the consent of
any Holders of Securities, to establish the form of any Security, as permitted by Section 2.1 of
the Base Indenture, and to provide for the issuance of the Notes (as defined below), as permitted
by Section 3.1 of the Base Indenture, and to set forth the terms thereof;

          WHEREAS, the Company desires to execute this First Supplemental Indenture pursuant to Section
2.1 of the Base Indenture to establish the form, and pursuant to Section 3.1 of the Base Indenture
to provide for the issuance, of a series of its senior notes designated as its 6.950% Notes due
2019 (the “Notes”), in an initial aggregate principal amount of $375,000,000. The Notes are a
series of securities as referred to in Section 3.1 of the Base Indenture.

          WHEREAS, the Company has requested that the Trustee execute and deliver this First
Supplemental Indenture;

          WHEREAS, all things necessary have been done by the Company to make this First Supplemental
Indenture, when executed and delivered by the Company, a valid supplement to the Indenture; and

          WHEREAS, all things necessary have been done by the Company to make the Notes, when executed
by the Company and authenticated and delivered in accordance with the provisions of the Indenture,
the valid obligations of the Company;

          NOW, THEREFORE, in consideration of the premises stated herein and the purchase of the Notes
by the Holders thereof, the Company and the Trustee mutually covenant and agree for the equal and
proportionate benefit of the respective Holders from time to time of the Notes as follows:

1

 

ARTICLE 1

APPLICATION OF SUPPLEMENTAL INDENTURE

          Section 1.01. Application of First Supplemental Indenture.

          Notwithstanding any other provision of this First Supplemental Indenture, all provisions of
this First Supplemental Indenture are expressly and solely for the benefit of the Holders of the
Notes and any such provisions shall not be deemed to apply to any other securities issued under the
Indenture and shall not be deemed to amend, modify or supplement the Base Indenture for any purpose
other than with respect to the Notes. Unless otherwise expressly specified, references in this
First Supplemental Indenture to specific Article numbers or Section numbers refer to Articles and
Sections contained in this Supplemental Indenture as they amend or supplement the Base Indenture,
and not the Base Indenture or any other document. All Initial Notes and Additional Notes, if any,
shall be treated as a single class for all purposes of this Indenture, including waivers,
amendments, redemptions and offers to purchase.

ARTICLE 2

DEFINITIONS

          Section 2.01. Certain Terms Defined in the Indenture.

          For purposes of this First Supplemental Indenture, all capitalized terms used but not defined
herein shall have the meanings ascribed to such terms in the Base Indenture, as amended hereby.

          Section 2.02. Definitions.

          For the benefit of the Holders of the Notes, Section 1.1 of the Base Indenture shall be
amended by adding the following new definitions:

          “Additional Notes” has the meaning specified in Section 3.02(b) hereto.

          “Attributable Debt” in respect of a Sale and Leaseback Transaction means, at the time of
determination, the present value (discounted at the imputed rate of interest of such transaction
determined in accordance with generally accepted accounting principles) of the obligation of the
lessee for net rental payments during the remaining term of the lease included in such arrangement
(including any period for which such lease has been extended or may, at the option of the lessor,
be extended). The term “net rental payments” under any lease for any period shall mean the sum of
the rental and other payments required to be paid in such period by the lessee thereunder, not
including any amounts required to be paid by such lessee (whether or not designated as rental or
additional rental) on account of maintenance and repairs, insurance, taxes, assessments, water
rates or similar charges required to be paid by such lessee thereunder or any amounts required to
be paid by such lessee thereunder contingent upon the amount of sales, maintenance and repairs,
insurance, taxes, assessments, water rates or similar charges.

          “Capitalized Lease Obligations” means obligations created pursuant to leases that are required
to be shown on the liability side of a balance sheet in accordance with FASB

2

 

Statement No. 13, “Accounting for Leases,” as amended and interpreted, or any successor or
comparable accounting standard.

          “Change of Control” means the occurrence of any of the following: (1) the direct or indirect
sale, lease, transfer, conveyance or other disposition (other than by way of merger or
consolidation), in one or more series of related transactions, of all or substantially all of the
Company’s assets and the assets of its Subsidiaries, taken as a whole, to any person, other than
the Company or one of its Subsidiaries; (2) the consummation of any transaction (including, without
limitation, any merger or consolidation) the result of which is that any person (other than the
Company or one of its Wholly-Owned Subsidiaries) becomes the beneficial owner (as defined in Rules
13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s
outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is
reclassified, consolidated, exchanged or changed, measured by voting power rather than number of
shares; (3) the first day on which a majority of the members of the Company’s Board of Directors
are not Continuing Directors; or (4) the adoption of a plan relating to the Company’s liquidation
or dissolution.

          The term “person”, as used in this definition, has the meaning given thereto in Section
13(d)(3) of the Exchange Act.

          “Change of Control Triggering Event” means the occurrence of both a Change of Control and a
Rating Event.

          “Comparable Treasury Issue” means the United States Treasury security or securities selected
by an Independent Investment Banker as having an actual or interpolated maturity comparable to the
remaining term of the Notes to be redeemed that would be utilized, at the time of selection and in
accordance with customary financial practice, in pricing new issues of corporate debt securities
of a comparable maturity to the remaining term of such Notes.

          “Comparable Treasury Price” means, with respect to any Redemption Date, (A) the average of the
Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and
lowest such Reference Treasury Dealer Quotations, or (B) if the Company obtains fewer than four
such Reference Treasury Dealer Quotations, the average of all such quotations.

          “Consolidated Net Tangible Assets” means the total amount of assets (less depreciation and
valuation reserves and other reserves and items deductible from the gross book value of specific
asset accounts under generally accepted accounting principles) that under generally accepted
accounting principles would be included on the Company’s and its Restricted Subsidiaries’
consolidated balance sheet, after deducting therefrom (i) amounts that would, in conformity with
generally accepted accounting principles, be included as current liabilities on such consolidated
balance sheet (other than (x) the current portion of any Funded Debt or Capitalized Lease
Obligations, (y) the current portion of accrued interest and (z) the current portion of current and
deferred income taxes), (ii) all goodwill, trade names, trademarks, patents, unamortized debt
discount and expense and other like intangibles (other than leasehold costs), which in each such
case would be so included on such balance sheet, and (iii) all amounts which

3

 

would be so included on such balance sheet in respect of Investments (less applicable
reserves) in Non-Restricted Subsidiaries in excess of the amount of such Investments at January 31,
2009.

          “Continuing Directors” means, as of any date of determination, any members of the Company’s
Board of Directors who (1) were members of the Company’s Board of Directors on the date the Notes
were issued or (2) were nominated for election, elected or appointed to the Company’s Board of
Directors with the approval of a majority of the Continuing Directors who were members of the
Company’s Board of Directors at the time of such nomination, election or appointment (either by a
specific vote or by approval of the Company’s proxy statement in which such member was named as a
nominee for election as a director, without objection to such nomination).

          “Exchange Act” means the Securities Exchange Act of 1934, as amended.

          “Funded Debt” of any person means Indebtedness, whether incurred, assumed or guaranteed,
maturing by its terms more than one year from the date of creation thereof, or that is extendable
or renewable at the sole option of the obligor so that it may become payable more than one year
from the date of creation thereof; provided, however, that Funded Debt shall not include (i)
obligations created pursuant to leases, (ii) any Indebtedness or portion thereof maturing by its
terms within one year from the time of any computation of the amount of outstanding Funded Debt
unless such Indebtedness shall be extendable or renewable at the sole option of the obligor in such
manner that it may become payable more than one year from such time, or (iii) any Indebtedness for
the payment or redemption of which money in the necessary amount shall have deposited in trust
either at or before the maturity date thereof.

          “Global Note” means the Note in the form of Global Securities issued to the Depositary or its
nominee, substantially in the form of Exhibit A.

          “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the
Company.

          “Initial Notes” has the meaning specified in Section 3.02(b) hereto.

          “Investment” means and includes any investment in stock, evidences of indebtedness, loans or
advances, however made or acquired, but shall not include the Company’s or any Restricted
Subsidiary’s accounts receivable arising from transactions in the ordinary course of business, or
any evidences of indebtedness, loans or advances made in connection with the sale to any Subsidiary
of the Company’s or any Restricted Subsidiary’s accounts receivable arising from transactions in
the Company’s or any Restricted Subsidiary’s ordinary course of business.

          “Investment Grade Rating” means a rating equal to or higher than Baa3 (or the equivalent) by
Moody’s and BBB — (or the equivalent) by S&P, and the equivalent investment grade credit rating
from any replacement Rating Agency or Rating Agencies selected by the Company.

          “Moody’s” means Moody’s Investors Service, Inc., and its successors.

4

 

          “Mortgage” and “Mortgages” have the meaning specified in Section 4.01(a) hereto.

          “Net Proceeds” means the aggregate cash proceeds received by the Company or any of its
Restricted Subsidiaries in respect of any Sale and Leaseback Transaction, net of the direct costs
relating to such Sale and Leaseback Transaction, including (i) legal, accounting and investment
banking fees, and brokerage and sales commissions, (ii) any relocation expenses incurred as a
result thereof, (iii) taxes paid or payable as a result thereof (after taking into account any
available tax credits or deductions and any tax sharing arrangements), (iv) amounts required to be
applied to the repayment of principal, premium, if any, and interest on Indebtedness secured by the
Operating Property or Operating Assets disposed of and required to be paid as a result of such
transaction and (v) any deduction of appropriate amounts to be provided by the Company or any
Restricted Subsidiary as a reserve in accordance with generally accepted accounting principles
against any liabilities associated with the Operating Property or Operating Assets disposed of in
such transaction and retained by the Company or any Restricted Subsidiary after such sale or other
disposition thereof.

          “Non-Restricted Subsidiary” means any Subsidiary other than a Restricted Subsidiary.

          “Notes” has the meaning specified in the recitals hereto.

          “Operating Assets” means all merchandise inventories, furniture, fixtures and equipment
(including all transportation and warehousing equipment but excluding office equipment and data
processing equipment) owned by the Company or a Restricted Subsidiary.

          “Operating Property” means all real property and improvements thereon owned by the Company or
a Restricted Subsidiary constituting, without limitation, any store, warehouse, service center or
distribution center wherever located; provided that such term shall not include any store,
warehouse, service center or distribution center that the Company’s Board of Directors declares by
resolution not to be of material importance to the Company’s and its Restricted Subsidiaries’
business. Operating Property is treated as having been “acquired” on the day the Operating
Property is placed in operation by the Company or a Restricted Subsidiary after the later of
(a) its acquisition from a third party, including a Non-Restricted Subsidiary, (b) completion of
its original construction or (c) completion of its substantial reconstruction, renovation,
remodeling, expansion or improvement (whether or not constituting an Operating Property prior to
such reconstruction, renovation, remodeling, expansion or improvement).

          “Rating Agencies” means (1) each of Moody’s and S&P; and (2) if either of Moody’s or S&P
ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons
outside of the Company’s control, a “nationally recognized statistical rating organization” within
the meaning of Rule 15c3-1(c)(2)(vi)(F) under the Exchange Act selected by the Company as a
replacement agency for Moody’s or S&P, or both of them, as the case may be.

          “Rating Event” means the rating on the Notes is lowered by both Rating Agencies and the Notes
are rated below an Investment Grade Rating by both Rating Agencies, in any case

5

 

on any day during the period (which period will be extended so long as the rating of the Notes
is under publicly announced consideration for a possible downgrade by any of the Rating Agencies)
commencing upon the first public notice of the occurrence of a Change of Control or the Company’s
intention to effect a Change of Control and ending 60 days following the consummation of the Change
of Control; provided that a Rating Event otherwise arising by virtue of a particular reduction in
rating shall not be deemed to have occurred in respect of a particular Change of Control (and thus
shall not be deemed a Rating Event for purposes of the definition of Change of Control Triggering
Event hereunder) if any of the Rating Agencies making the reduction in rating to which this
definition would otherwise apply does not announce or publicly confirm or inform the Trustee in
writing at its request that the reduction was the result, in whole or in part, of any event or
circumstance comprised of or arising as a result of, or in respect of, the applicable Change of
Control (whether or not the applicable Change of Control shall have occurred at the time of the
Rating Event).

          “Reference Treasury Dealer” means each of Banc of America Securities LLC, J.P. Morgan
Securities Inc., RBS Securities Inc. or their affiliates that are primary U.S. Government
securities dealers and two other primary U.S. Government securities dealers in the City of New York
selected by the Company, and their respective successors; provided, however, that if any of the
foregoing or their affiliates shall cease to be a primary U.S. Government securities dealer in The
City of New York, the Company shall substitute therefor another such primary U.S. Government
securities dealer.

          “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer
and any Redemption Date, the average, as determined by the Company, of the bid and asked prices for
the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount)
quoted in writing to the Company by such Reference Treasury Dealer at 3:30 p.m. New York time on
the third Business Day preceding such Redemption Date.

          “Restricted Subsidiary” means any Subsidiary so designated by the Company’s Board of Directors
or the Company’s duly authorized Officers in accordance with this First Supplemental Indenture
provided that (a) the Company’s Board of Directors or its duly authorized Officers may, subject to
certain limitations, designate any Non-Restricted Subsidiary as a Restricted Subsidiary and any
Restricted Subsidiary as a Non-Restricted Subsidiary and (b) any Subsidiary of which the majority
of the voting stock is owned directly or indirectly by one or more Non-Restricted Subsidiaries
shall be a Non-Restricted Subsidiary.

          “Sale and Leaseback Transaction” has the meaning specified in Section 4.02 hereto.

          “Senior Funded Debt” means all of the Company’s Funded Debt (except Funded Debt, the payment
of which is expressly subordinated to the payment of the Notes).

          “S&P” means Standard & Poor’s Rating Services, a division of The McGraw-Hill Companies, Inc.,
and its successors.

          “Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the
semiannual equivalent yield to maturity or interpolated maturity (on a day count

6

 

basis) of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue
(expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such
Redemption Date.

          “Voting Stock” means, with respect to any specified “person” (as that term is used in Section
13(d)(3) of the Exchange Act) as of any date, the capital stock of such person that is at the time
entitled to vote generally in the election of the board of directors of such person.

          “Wholly Owned Restricted Subsidiary” means any Restricted Subsidiary, all of the capital stock
of which, other than directors’ qualifying shares, is owned by the Company and its other Wholly
Owned Restricted Subsidiaries.

ARTICLE 3

FORM AND TERMS OF THE NOTES

          Section 3.01. Form and Dating.

          (a) The Notes and the Trustee’s certificate of authentication shall be substantially in the
form of Exhibit A attached hereto. The Notes shall be executed on behalf of the Company by
an Officer of the Company and attested by its Secretary or one of its Assistant Secretaries. The
Notes may have notations, legends or endorsements required by law, stock exchange rules or usage.
Each Note shall be dated the date of its authentication. The Notes and any beneficial interest in
the Notes shall be in minimum denominations of $2,000 and integral multiples of $1,000 in excess
thereof.

          (b) The terms and notations contained in the Notes shall constitute, and are hereby expressly
made, a part of the Indenture, and the Company and the Trustee, by their execution and delivery of
this First Supplemental Indenture, expressly agree to such terms and provisions and to be bound
thereby.

          (c) Global Note. The Notes shall be issued initially in the form of fully registered
Global Securities (the “Global Note”), which shall be deposited on behalf of the purchasers of the
Notes represented thereby with The Depository Trust Company, New York, New York (the “Depositary”)
and registered in the name of Cede & Co., the Depositary’s nominee, duly executed by the Company,
authenticated by the Trustee.

          (d) Book-Entry Provisions. This Section 3.01(d) shall apply only to the Global Note
deposited with or on behalf of the Depositary. The Company shall execute and the Trustee shall, in
accordance with this Section 3.01(d), authenticate and deliver the Global Note that shall be
registered in the name of the Depositary or the nominee of the Depositary and shall be delivered by
the Trustee to the Depositary or pursuant to the Depositary’s instructions.

          (e) Paying Agent. The Company initially appoints the Trustee as Paying Agent for the
payment of the principal of (and premium, if any) and interest on the Notes and the office of the
Trustee at U.S. Bank National Association, 100 Wall Street, 16th Floor, New York, New
York 10005, be and hereby is, designated as the Place of Placement where the Notes may be presented
for payment.

7

 

          Section 3.02. Terms of the Notes. The following terms relating to the Notes are
hereby established:

          (a) Title. The Notes shall constitute a series of Securities having the title “6.950%
Notes due 2019”.

          (b) Principal Amount. The aggregate principal amount of the Notes that may be
initially authenticated and delivered under the Indenture (the “Initial Notes”) shall be
$375,000,000 (except for Notes authenticated and delivered upon registration of, transfer of, or in
exchange for, or in lieu of, other Notes pursuant to Sections 3.4, 3.5, 3.6, 9.6 or 11.7 of the
Indenture). The Company may from time to time, without the consent of the Holders of Notes, issue
additional Notes (in any such case “Additional Notes”) having the same ranking and the same
interest rate, Maturity and other terms as the Initial Notes. Any Additional Notes and the Initial
Notes shall constitute a single series under the Indenture and all references to the Notes shall
include the Initial Notes and any Additional Notes unless the context otherwise requires.

          (c) Maturity Date. The entire outstanding principal amount of the Notes shall be
payable on April 15, 2019.

          (d) Interest Rate. The rate at which the Notes shall bear interest shall be 6.950%
per annum; the date from which interest shall accrue on the Notes shall be April 7, 2009, or the
most recent Interest Payment Date to which interest has been paid or provided for; the Interest
Payment Dates for the Notes shall be April 15 and October 15 of each year, beginning October 15,
2009; the interest so payable, and punctually paid or duly provided for, on any Interest Payment
Date, will be paid, in immediately available funds, to the Persons in whose names the Note (or
predecessor Note) is registered (which shall initially be the Depository) at the close of business
on the Regular Record Date for such interest, which shall be the April 1 or October 1, as the case
may be, next preceding such Interest Payment Date. Interest shall be computed on the basis of a
360-day year comprised of twelve 30-day months. For so long as the Notes are represented in global
form by one or more Global Securities, all payments of principal (and premium, if any) and interest
shall be made by wire transfer of immediately available funds to the Depositary or
its nominee, as the case may be, as the registered owner of the Global Security representing such
Notes. In the event that definitive Notes shall have been issued, all payments of principal (and
premium, if any) and interest shall be made by wire transfer of immediately
available funds to the accounts of the registered Holders thereof; provided, that the
Company may elect to make such payments at the office of the Paying Agent in The City of New York;
and provided further, that the Company may at its option pay interest by check to
the registered address of each Holder of a definitive Note.

          (e) Currency. The currency of denomination of the Notes is United States Dollars.
Payment of principal of and interest and premium, if any, on the Notes shall be made in United
States Dollars.

          (f) Sinking Fund. The Notes are not subject to any sinking fund.

          Section 3.03. Optional Redemption.

8

 

          (a) The provisions of Article 11 of the Base Indenture, as supplemented by the provisions of
this First Supplemental Indenture, shall apply to the Notes.

          (b) The Notes shall be redeemable as a whole or in part, at the Company’s option at any time,
at a Redemption Price equal to the greater of (i) 100% of the principal amount of the Notes to be
redeemed and (ii) the sum of the present values of the remaining scheduled payments of principal
and interest thereon (exclusive of interest accrued and unpaid to the date of redemption)
discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of
twelve 30-day months) at the Treasury Rate plus 50 basis points, plus, in each case, accrued and
unpaid interest thereon to, but not including, the date of redemption. Further, installments of
interest on the Notes to be redeemed that are due and payable on the Interest Payment Dates falling
on or prior to the Redemption Date shall be payable on the Interest Payment Date to the registered
Holders as of the close of business on the relevant Regular Record Date according to the Notes and
the Indenture.

          (c) Notice of any redemption shall be mailed at least 30 days but not more than 60 days before
the Redemption Date to each Holder of the Notes to be redeemed; provided that notice of
redemption may be mailed more than 60 days prior to the Redemption Date if the notice is issued in
connection with a defeasance of the Notes or a satisfaction and discharge of Notes. If less than
all of the Notes are to be redeemed, the Notes to be redeemed shall be selected by the Trustee by
lot or any other such method as the Trustee deems to be fair and appropriate.

          (d) Unless the Company defaults in payment of the Redemption Price, on and after the
Redemption Date interest shall cease to accrue on the Notes or portions thereof called for
redemption.

          Section 3.04. Repurchase of Notes upon a Change of Control.

          (a) If a Change of Control Triggering Event occurs with respect to the Notes, unless the
Company has exercised its option to redeem the Notes as provided in Section 3.03, the Company shall
make an offer (a “Change of Control Offer”) to each Holder of the Notes to repurchase all or any
part (equal to any integral multiple of $1,000, such that any remaining portion held be such Holder
is at least $2,000) of that Holder’s Notes on the terms set forth in this Section 3.04 and in the
Notes. In a Change of Control Offer, the Company shall offer payment in cash equal to 101% of the
aggregate principal amount of Notes repurchased, plus accrued and unpaid interest, if any, on the
Notes repurchased to the date of repurchase (a “Change of Control Payment”). Within 30 days
following any Change of Control Triggering Event or, at the Company’s option, prior to any Change
of Control, but after public announcement of the transaction that constitutes or may constitute the
Change of Control, a notice shall be mailed to Holders of the Notes, describing the transaction
that constitutes or may constitute the Change of Control Triggering Event and offering to
repurchase the Notes on the date specified in the applicable notice, which date shall be no earlier
than 30 days and no later than 60 days from the date such notice is mailed (a “Change of Control
Payment Date”). The notice shall, if mailed prior to the date of consummation of the Change of
Control, state that the Change of Control Offer is conditioned on the Change of Control Triggering
Event occurring on or prior to the applicable Change of Control Payment Date; provided, that the
expiration of the Change of Control Offer prior to consummation of such Change of Control shall not
relieve the

9

 

Company of its obligation under this Section 3.04 if such Change of Control subsequently
occurs.

          (b) On each Change of Control Payment Date, the Company shall, to the extent lawful:

     (i) accept for payment all Notes or portions of Notes properly tendered
pursuant to the applicable Change of Control Offer;

     (ii) deposit with the Paying Agent an amount equal to the Change of Control
Payment in respect of all Notes or portions of Notes properly tendered; and

     (iii) deliver or cause to be delivered to the Trustee the Notes properly
accepted together with an Officers’ Certificate stating the aggregate principal
amount of Notes or portions of Notes being repurchased.

          (c) The Company shall not be required to make a Change of Control Offer upon the occurrence of
a Change of Control Triggering Event if a third party makes such an offer in the manner, at the
times and otherwise in compliance with the requirements for an offer made by the Company and the
third party purchases all Notes properly tendered and not withdrawn under its offer. In addition,
the Company shall not repurchase any Notes if there has occurred and is continuing on the Change of
Control Payment Date an Event of Default under the Indenture, other than a default in the payment
of the Change of Control Payment.

          (d) The Company shall comply with the requirements of Rule 14e-1 under the Exchange Act, and
any other securities laws and regulations thereunder to the extent those laws and regulations are
applicable in connection with the repurchase of the Notes as a result of a Change of Control
Triggering Event. To the extent that the provisions of any securities laws or regulations conflict
with the Change of Control Offer provisions of the Notes, the Company shall comply with those
securities laws and regulations and shall not be deemed to have breached its obligations under the
Change of Control Offer provisions of the Notes by virtue of any such conflict and compliance.

          Section 3.05. Certain Interest Payments

          Installments of interest that are due and payable on Notes to be repurchased or redeemed on a
Change of Control Payment Date or Redemption Date, as the case may be, between a Regular Record
Date and an Interest Payment Date shall be payable on the Change of Control Payment Date or
Redemption Date, as the case may be, to the registered Holders as of the close of business on the
relevant Regular Record Date according to the Notes and the Indenture.

10

 

ARTICLE 4

CERTAIN COVENANTS

          The following covenants shall be applicable to the Company for so long as any of the Notes are
Outstanding. Nothing in this Article will, however, affect the Company’s rights or obligations
under any other provision of the Base Indenture or this First Supplemental Indenture.

          Section 4.01. Restrictions on Secured Debt

          (a) The Company shall not, and shall not permit any Restricted Subsidiary to issue, assume or
guarantee any Indebtedness secured by any mortgage, security interest, pledge, lien or other
encumbrance (herein referred to as a “Mortgage” or “Mortgages”) upon any Operating Property or
Operating Assets of the Company or any Restricted Subsidiary, whether such Operating Property or
Operating Asset is now owned or hereafter acquired, without in any such case effectively providing
concurrently with the issuance, assumption or guarantee of any such Indebtedness that the Notes
(together with, if the Company shall so determine, any other Indebtedness ranking equally with the
Notes other than Securities not having the benefit of this Section 4.1) shall be secured equally
and ratably with such Indebtedness, except that the foregoing restrictions shall not apply to:

     (i) the giving, within 180 days after the later of the acquisition or completion of
construction or completion of substantial reconstruction, renovation, remodeling, expansion
or improvement (each a “substantial improvement”) of such property, and the placing in
operation of such property after the acquisition or completion of any such construction or
substantial improvement, of any purchase money Mortgage (including security for bankers
acceptances and similar inventory financings in the ordinary course of business and vendors’
rights under purchase contracts under an agreement whereby title is retained for the purpose
of securing the purchase price thereof), or the acquiring of property not theretofore owned
by the Company or such Restricted Subsidiary subject to any then existing Mortgage securing
Indebtedness (whether or not assumed) including Indebtedness incurred for reimbursement of
funds previously expended for any such purpose, provided that in each case (x) such Mortgage
is limited to such property, including accretions thereto and any such construction or
substantial improvement (or, with respect to bankers acceptances and similar inventory
financings in the ordinary course of business, any inventory acquired by the Company or such
Restricted Subsidiary during the 180-day period immediately preceding the date of creation
of such Mortgage); (y) the principal amount of the Indebtedness being incurred that is
secured by such Mortgage shall not exceed the cost of such acquired property, construction
or substantial improvement, as the case may be; and (z) the principal amount of the
Indebtedness secured by such Mortgage, together with all other Indebtedness to persons other
than the Company or a Restricted Subsidiary secured by Mortgages on such property, shall not
exceed the total cost of such property, including any such construction or substantial
improvement;

     (ii) the giving by the Company or a Restricted Subsidiary of a Mortgage on real
property that is the sole security for Indebtedness (w) incurred within three years

11

 

after the latest of (1) the date of acquisition of such real property or (2) the date
of completion of construction or substantial improvement made thereon by the Company or such
Restricted Subsidiary, (x) incurred for the purpose of reimbursing itself for the cost of
acquisition and/or the cost of improvement of such real property, (y) the amount of which
does not exceed the aggregate cost of such real property and improvements, and (z) the
Holder of which shall be entitled to enforce payment of such Indebtedness solely by
resorting to the security therefor, without any liability on the part of the Company or such
Restricted Subsidiary for any deficiency;

     (iii) any Mortgage on the Company’s or any Subsidiary’s assets existing on the date of
this First Supplemental Indenture or any Mortgage on the assets of any person on the date it
became a Subsidiary or is merged into or consolidated with the Company or any Subsidiary or
any Mortgage on the assets of a Subsidiary that is newly designated as a Restricted
Subsidiary, if such Mortgage was created while such Subsidiary was a Non- Restricted
Subsidiary, and such Mortgage would have been permitted under the provisions of this
paragraph if such Subsidiary had been a Restricted Subsidiary at the time such Mortgage was
created;

     (iv) any Mortgage incurred in connection with any refunding or extension of
Indebtedness secured by a Mortgage permitted under clauses (i) to (iii) above, provided that
the principal amount of the refinancing or extending Indebtedness does not exceed the
principal amount of the Indebtedness so refunded or extended and that such Mortgage applies
only to the same property or assets subject to the prior permitted Mortgage and fixtures and
building improvements thereon (and if the prior Mortgage was incurred under clause (ii)
above, the requirements of clause (z) thereof are satisfied); or

     (v) any Mortgage given in favor of the Company or any Wholly Owned Restricted
Subsidiary.

          Section 4.02. Restrictions on Sale and Leaseback Transactions

          The Company shall not, and shall not permit any Restricted Subsidiary to, enter into any
arrangement with any person providing for the leasing by the Company or any Restricted Subsidiary
of any Operating Property or Operating Asset that has been or is to be sold or transferred by the
Company or such Restricted Subsidiary to such person subsequent to the date of this First
Supplemental Indenture with the intention of taking back a lease of such property (a “Sale and
Leaseback Transaction”) unless the terms of such sale or transfer have been determined by the
Company to be fair and arm’s length and, within 180 days after the receipt of the proceeds of such
sale or transfer, the Company or any Restricted Subsidiary (1) apply an amount equal to the Net
Proceeds of such sale or transfer of such Operating Property or Operating Asset at the time of such
sale or transfer to the prepayment or retirement (other than any mandatory prepayment or
retirement) of Senior Funded Debt of the Company or Funded Debt of such Restricted Subsidiary or
(2) reinvest the Net Proceeds of such sale or transfer in assets used or useful for the Company’s
and its Restricted Subsidiaries’ business. The foregoing restriction shall not apply to (i) any
Sale and Leaseback Transaction for a term of not more than three years including renewals, (ii) any
Sale and Leaseback Transaction with respect to Operating Property if a binding commitment with
respect thereto is entered into within three

12

 

years after the date such property was acquired (as the term “acquired” is used in the
definition of Operating Property) or any Sale and Leaseback Transaction with respect to Operating
Assets if a binding commitment with respect thereto is entered into within 180 days after the later
of the date such property was acquired and, if applicable, the date such property was first placed
in operation, or (iii) any Sale and Leaseback Transaction between the Company and a Restricted
Subsidiary or between Restricted Subsidiaries provided that the lessor shall be the Company or a
Wholly Owned Restricted Subsidiary.

          Section 4.03. Exempted Debt

          Notwithstanding the restrictions on Mortgages and on Sale and Leaseback Transactions provided
in Sections 4.01 and 4.02, the Company and its Restricted Subsidiaries may create or assume
Mortgages, and renew, extend or replace such Mortgages, or enter into Sale and Leaseback
Transactions, provided that, after giving effect thereto, the aggregate principal amount of all
Indebtedness secured by Mortgages, which would otherwise be subject to Sections 4.01 and 4.02
(other than any Indebtedness secured by Mortgages permitted by clauses (i) through (v) of Section
4.01), together with all Attributable Indebtedness with respect to Sale and Leaseback Transactions,
which would otherwise be subject to these restrictions (other than with respect to Sale and
Leaseback Transactions that are permitted as provided under Section 4.02) does not exceed 15% of
Consolidated Net Tangible Assets.

          Section 4.04. Limitations Upon Permitting Restricted Subsidiaries to become Non-Restricted
Subsidiaries and Non-Restricted Subsidiaries to become Restricted Subsidiaries

          (a) The Company shall not permit any Restricted Subsidiary to be designated as or otherwise to
become a Non-Restricted Subsidiary unless immediately after such Restricted Subsidiary becomes a
Non-Restricted Subsidiary, it will not own, directly or indirectly, any capital stock of any other
Restricted Subsidiary or any Mortgage on property of any other Restricted Subsidiary.

          (b) The Company shall not permit any Non-Restricted Subsidiary that has previously been a
Restricted Subsidiary to be designated as a Restricted Subsidiary unless such Non-Restricted
Subsidiary shall not, at any time after it ceased to be a Restricted Subsidiary have participated
in any sale and leaseback transaction involving any Operating Property or Operating Asset owned by
such Subsidiary, the Company or any Restricted Subsidiary (other than in a transaction permitted
under Section 4.02 for such Subsidiary if it had been a Restricted Subsidiary at the time), unless
the Operating Property or Operating Asset involved in such transaction shall no longer be leased by
the Company or any Restricted Subsidiary or such Subsidiary or shall be owned by the Company or a
Wholly Owned Restricted Subsidiary.

          (c) Promptly after the adoption of any Board Resolution designating a Restricted Subsidiary as
a Non-Restricted Subsidiary or a Non-Restricted Subsidiary as a Restricted Subsidiary, or the
making of an election by duly authorized Officers of the Company to effect any such designation, a
copy of such Board Resolution or a written statement as to such designation signed by such Officers
shall be filed with the Trustee, together with an Officers’ Certificate stating that the provisions
of this Section 4.04 have been complied with in connection with such designation, and, in case of
the designation of a Restricted Subsidiary as a Non-

13

 

	 	 	Restricted Subsidiary, setting forth the name of each other Subsidiary (if any) that has
become a Non-Restricted Subsidiary as a result of such designation.

ARTICLE 5

MISCELLANEOUS

          Section 5.01. Trust Indenture Act Controls.

          If any provision of this First Supplemental Indenture limits, qualifies or conflicts with
another provision which is required to be included in this First Supplemental Indenture by the TIA,
the required provision shall control. If any provision of this First Supplemental Indenture
modifies or excludes any provision of the TIA which may be so modified or excluded, the latter
provision shall be deemed to apply to this First Supplemental Indenture as so modified or to be
excluded, as the case may be.

          Section 5.02. New York Law to Govern.

          The First Supplemental Indenture and the Notes shall be governed by and construed in
accordance with the laws of the State of New York.

          Section 5.03. Counterparts.

          This First Supplemental Indenture may be executed in any number of counterparts, each of which
so executed shall be deemed to be an original, but all such counterparts shall together constitute
but one and the same instrument.

          Section 5.04. Severability. If any provision of this First Supplemental Indenture or the
Notes shall be held to be illegal or unenforceable under applicable law, then the remaining
provisions hereof shall be construed as though such invalid, illegal or unenforceable provision
were not contained therein.

          Section 5.05. Ratification.

          The Base Indenture, as supplemented and amended by this First Supplemental Indenture, is in
all respects ratified and confirmed. The Indenture shall be read, taken and construed as one and
the same instrument. All provisions included in this First Supplemental Indenture supersede any
conflicting provisions included in the Base Indenture unless not permitted by law. The Trustee
accepts the trusts created by the Indenture, and agrees to perform the same upon the terms and
conditions of the Indenture.

          Section 5.06. Effectiveness.

          The provisions of this First Supplemental Indenture shall become effective as of the date
hereof.

          Section 5.07. Trustee Makes No Representation.

14

 

          The recitals contained herein are made by the Company and not by the Trustee, and the Trustee
assumes no responsibility for the correctness thereof. The Trustee makes no representation as to
the validity or sufficiency of this First Supplemental Indenture. All rights, protections,
privileges, indemnities and benefits granted or afforded to the Trustee under the Indenture shall
be deemed incorporated herein by this reference and shall be deemed applicable to all actions
taken, suffered or omitted by the Trustee in each of its capacities hereunder, and each agent,
custodian and other Person employed to act under this First Supplemental Indenture.

[Remainder of page intentionally left blank.]

15

 

          IN WITNESS WHEREOF, the parties hereto have caused this First Supplemental Indenture to be
duly executed as of the date first above written.

	 	 	 	 	 
	 	The TJX Companies, Inc.

 	 
	 	By:  	
/s/ Mary B. Reynolds	 
	 	 	Name:  	Mary B. Reynolds	 
	 	 	Title:  	Senior Vice President and Treasurer	 
	 

Attest:

	 	 	 	 	 
	By:
	 	/s/ Ann McCauley	 	 
	 

	 	 

Name: Ann McCauley
	 	 
	 

	 	Title: Executive Vice President, 

         General Counsel and Secretary	 	 

Signature Page to First Supplemental Indenture

 

 

	 	 	 	 	 
	 	U.S. Bank National Association

 	 
	 	By:  	/s/   Carolina D. Altomare
 	 
	 	 	Name:  	Carolina D. Altomare	 
	 	 	Title:  	Vice President	 
	 

Signature Page to First Supplemental Indenture

 

 

Exhibit A

THIS NOTE IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS
REGISTERED IN THE NAME OF A DEPOSITARY (AS DEFINED IN THE INDENTURE) OR A NOMINEE THEREOF. THIS
GLOBAL SECURITY IS EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF ANY PERSON OTHER THAN SUCH
DEPOSITARY OR ITS NOMINEE ONLY IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND, UNLESS AND
UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM, THIS GLOBAL SECURITY
MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY, OR BY A
NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY, OR BY THE
DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST
COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY (AS DEFINED BELOW) OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY SECURITY ISSUED IS REGISTERED IN THE NAME OF
CEDE & CO. OR IN SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY
PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO
ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

THE TJX COMPANIES, INC.

6.950% Note due 2019

	 	 	 	 	 
	No. 1

	 	Principal Amount

	CUSIP No. 872540 AM1

	 	 	$	375,000,000

     The TJX Companies, Inc., a Delaware corporation (hereinafter called the “Company”, which term
includes any successor Person under the Indenture referred to below), for value received, hereby
promises to pay to Cede & Co., or registered assigns, the principal sum of THREE HUNDRED
SEVENTY-FIVE MILLION U.S. Dollars (U.S. $375,000,000) on April 15, 2019 and to pay interest thereon
from April 7, 2009 or from the most recent Interest Payment Date to which interest has been paid or
duly provided for, semi-annually on April 15 and October 15 in each year (each an “Interest Payment
Date”), beginning October 15, 2009 at the rate of 6.950% per annum, until the principal hereof is
paid or duly made available for payment. The interest so payable and punctually paid or duly
provided for on any Interest Payment Date shall, as provided in such Indenture, be paid to the
Person in whose name this Note (or one or more Predecessor Securities) is registered at the close
of business on the Regular Record Date for such interest, which shall be the April 1 or October 1
(whether or not a Business Day), as the case may be, next preceding such Interest Payment Date.
Any such interest which is payable, but is not punctually paid or duly provided for, on any
Interest Payment Date shall forthwith cease to be payable to the Holder hereof on the relevant
Regular Record Date by virtue

6.950% Note due 2019

1

 

of having been such Holder, and may be paid to the Person in whose name this Note (or one or
more Predecessor Securities) is registered at the close of business on a Special Record Date for
the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to
Holders of the Notes not less than 10 days prior to such Special Record Date, or may be paid at any
time in any other lawful manner not inconsistent with the requirements of any securities exchange
on which the Notes may be listed, and upon such notice as may be required by such exchange, all as
more fully provided in said Indenture.

     Payment of the principal of (and premium, if any) and the interest on this Note shall be made
at the designated office of the Trustee (as defined below) at U.S. Bank National Association, 100
Wall Street, 16th Floor, New York, New York, 10005, in such currency of the United
States of America as at the time of payment is legal tender for payment of public and private
debts; provided, however, for so long as the Notes are represented in global form
by one or more Global Securities, all payments of principal (and premium, if any) and interest
shall be made by wire transfer of immediately available funds to the Depositary or
its nominee, as the case may be, as the registered owner of the Global Security representing such
Notes. In the event that definitive Notes shall have been issued, all payments of principal (and
premium, if any) and interest shall be made by wire transfer of immediately
available funds to the accounts of the registered Holders thereof; provided, that the
Company may at its option pay interest by check to the registered address of each Holder of a
definitive Note.

     This Note is one of the duly authorized series of Securities of the Company, designated as the
Company’s “6.950% Notes due 2019”, initially limited to an aggregate principal amount of
$375,000,000, all issued or to be issued under and pursuant to an Indenture (the “Base
Indenture”), dated as of April 2, 2009, between the Company and U.S. Bank National Association, as
Trustee (hereinafter referred to as the “Trustee”), as supplemented by the First Supplemental
Indenture thereto, dated as of April 7, 2009 (the “First Supplemental Indenture”, and together with
the Base Indenture, the “Indenture”). Reference is hereby made to the Indenture for a description
of the respective rights, limitation of rights, obligations, duties and immunities thereunder of
the Trustee, the Company and the Holders of the Notes.

     The Company may redeem the Notes as a whole or in part, at the Company’s option at any time,
at a Redemption Price equal to the greater of: (i) 100% of the principal amount of the Notes to be
redeemed; and (ii) the sum of the present values of the remaining scheduled payments of principal
and interest thereon (exclusive of interest accrued and unpaid to the date of redemption)
discounted to the Redemption Date on a semiannual basis (assuming a 360-day year consisting of
twelve 30-day months) at the Treasury Rate (as defined below), plus 50 basis points, plus in each
case accrued and unpaid interest thereon to, but not including, the date of redemption. Further,
installments of interest on the Notes to be redeemed that are due and payable on the Interest
Payment Dates falling on or prior to a Redemption Date shall be payable on the Interest Payment
Date to the registered Holders as of the close of business on the relevant Regular Record Date.

     For purposes of the optional redemption provisions of this Note, the following terms shall be
applicable:

6.950% Note due 2019

2

 

     “Comparable Treasury Issue” means the United States Treasury security or securities selected
by an Independent Investment Banker as having an actual or interpolated maturity comparable to the
remaining term of the Notes to be redeemed that would be utilized, at the time of selection and in
accordance with customary financial practice, in pricing new issues of corporate debt securities
of a comparable maturity to the remaining term of such Notes.

     “Comparable Treasury Price” means, with respect to any Redemption Date, (A) the average of the
Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and
lowest such Reference Treasury Dealer Quotations, or (B) if the Company obtains fewer than four
such Reference Treasury Dealer Quotations, the average of all such quotations.

     “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the
Company.

     “Reference Treasury Dealer” means each of Banc of America Securities LLC, J.P. Morgan
Securities Inc., RBS Securities Inc. or their affiliates that are primary U.S. Government
securities dealers and two other primary U.S. Government securities dealers in the City of New York
selected by the Company, and their respective successors; provided, however, that if any of the
foregoing or their affiliates shall cease to be a primary U.S. Government securities dealer in The
City of New York, the Company shall substitute therefor another such primary U.S. Government
securities dealer.

     “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer
and any Redemption Date, the average, as determined by the Company, of the bid and asked prices for
the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount)
quoted in writing to the Company by such Reference Treasury Dealer at 3:30 p.m. New York time on
the third Business Day preceding such Redemption Date.

     “Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the
semiannual equivalent yield to maturity or interpolated maturity (on a day count basis) of the
Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a
percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption
Date.

     Notice of any redemption shall be mailed at least 30 days but not more than 60 days before the
Redemption Date to each Holder of Notes to be redeemed; provided that notice of redemption may be
mailed more than 60 days prior to a Redemption Date if the notice is issued in connection with a
defeasance of the Notes or a satisfaction and discharge of Notes.

     If less than all of the Notes are to be redeemed, the Notes to be redeemed shall be selected
by the Trustee by lot or any other such method as the Trustee deems to be fair and appropriate.

     Unless the Company defaults in payment of the Redemption Price, on and after the Redemption
Date, interest shall cease to accrue on the Notes or portions thereof called for redemption.

6.950% Note due 2019

3

 

     If a Change of Control Triggering Event (as defined below) occurs with respect to the Notes,
unless the Company has exercised its option to redeem the Notes as described above, the Company
shall make an offer (a “Change of Control Offer”) to each Holder of the Notes to repurchase all or
any part (equal to any integral multiple of $1,000, such that any remaining portion held be such
Holder is at least $2,000) of that Holder’s Notes on the terms set forth herein. In a Change of
Control Offer, the Company shall offer payment in cash equal to 101% of the aggregate principal
amount of Notes repurchased, plus accrued and unpaid interest, if any, on the Notes repurchased to
the date of repurchase (a “Change of Control Payment”).

     Within 30 days following any Change of Control Triggering Event or, at the Company’s option,
prior to any Change of Control (as defined below), but after public announcement of the transaction
that constitutes or may constitute the Change of Control, a notice shall be mailed to Holders of
the Notes, describing the transaction that constitutes or may constitute the Change of Control
Triggering Event and offering to repurchase the Notes on the date specified in the applicable
notice, which date shall be no earlier than 30 days and no later than 60 days from the date such
notice is mailed (a “Change of Control Payment Date”). The notice shall, if mailed prior to the
date of consummation of the Change of Control, state that the Change of Control Offer is
conditioned on the Change of Control Triggering Event occurring on or prior to the applicable
Change of Control Payment Date; provided, that the expiration of the Change of Control Offer prior
to consummation of such Change of Control will not relieve the Company of its obligation herein if
such Change of Control subsequently occurs.

     On each Change of Control Payment Date, the Company shall, to the extent lawful:

	 	(i)	 	accept for payment all Notes or portions of Notes properly
tendered pursuant to the applicable Change of Control Offer;
	 
	 	(ii)	 	deposit with the Paying Agent an amount equal to the Change of
Control Payment in respect of all Notes or portions of Notes properly tendered;
and
	 
	 	(iii)	 	deliver or cause to be delivered to the Trustee the Notes
properly accepted, together with an Officers’ Certificate stating the aggregate
principal amount of Notes or portions of Notes being repurchased.

     The Company shall not be required to make a Change of Control Offer upon the occurrence of a
Change of Control Triggering Event if a third party makes such an offer in the manner, at the times
and otherwise in compliance with the requirements for an offer made by the Company and the third
party purchases all Notes properly tendered and not withdrawn under its offer. In addition, the
Company shall not repurchase any Notes if there has occurred and is continuing on the Change of
Control Payment Date an Event of Default under the Indenture, other than a default in the payment
of the Change of Control Payment.

     The Company shall comply with the requirements of Rule 14e-1 under the Securities Exchange Act
of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations thereunder,
to the extent those laws and regulations are applicable in

6.950% Note due 2019

4

 

connection with the repurchase of the Notes as a result of a Change of Control Triggering
Event. To the extent that the provisions of any securities laws or regulations conflict with the
Change of Control Offer provisions of the Notes, the Company shall comply with those securities
laws and regulations and shall not be deemed to have breached its obligations under the Change of
Control Offer provisions of the Notes by virtue of any such conflict and compliance.

     Installments of interest that are due and payable on Notes to be repurchased on a Change of
Control Payment Date between a Regular Record Date and an Interest Payment Date shall be payable on
the Change of Control Payment Date to the registered Holders as of the close of business on the
relevant Regular Record Date according to this Note and the Indenture.

     For purposes of the Change of Control Offer provisions of the Notes, the following terms shall
be applicable:

     “Change of Control” means the occurrence of any of the following:

	 	(1)	 	the direct or indirect sale, lease, transfer, conveyance or
other disposition (other than by way of merger or consolidation), in one or
more series of related transactions, of all or substantially all of the
Company’s assets and the assets of its Subsidiaries, taken as a whole, to any
person, other than the Company or one of its Subsidiaries;
	 
	 	(2)	 	the consummation of any transaction (including, without
limitation, any merger or consolidation) the result of which is that any person
(other than the Company or one of its Wholly Owned Subsidiaries) becomes the
beneficial owner (as defined in Rules 13d-3 and 13d-5 under the Exchange Act),
directly or indirectly, of more than 50% of the Company’s outstanding Voting
Stock or other Voting Stock into which the Company’s Voting Stock is
reclassified, consolidated, exchanged or changed, measured by voting power
rather than number of shares;
	 
	 	(3)	 	the first day on which a majority of the members of the
Company’s Board of Directors are not Continuing Directors; or
	 
	 	(4)	 	the adoption of a plan relating to the Company’s liquidation or
dissolution.

     The term “person,” as used in this definition, has the meaning given thereto in Section
13(d)(3) of the Exchange Act.

     “Change of Control Triggering Event” means the occurrence of both a Change of Control and a
Rating Event.

     “Continuing Directors” means, as of any date of determination, any members of the Company’s
Board of Directors who (1) were members of the Company’s Board of Directors on the date the Notes
were issued; or (2) were nominated for election, elected or appointed to the Company’s Board of
Directors with the approval of a majority of the Continuing Directors who were members of the
Company’s Board of Directors at the time of such nomination, election or appointment (either by a
specific vote or by approval of the Company’s proxy statement in

6.950% Note due 2019

5

 

which such member was named as a nominee for election as a director, without objection to such
nomination).

     “Investment Grade Rating” means a rating equal to or higher than Baa3 (or the equivalent) by
Moody’s and BBB- (or the equivalent) by S&P, and the equivalent investment grade credit rating from
any replacement Rating Agency or Rating Agencies selected by the Company.

     “Moody’s” means Moody’s Investors Service, Inc. and its successors.

     “Rating Agencies” means (1) each of Moody’s and S&P; and (2) if either of Moody’s or S&P
ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons
outside of the Company’s control, a “nationally recognized statistical rating organization” within
the meaning of Rule 15c3-1(c)(2)(vi)(F) under the Exchange Act, selected by the Company as a
replacement agency for Moody’s or S&P, or both of them, as the case may be.

     “Rating Event” means the rating on the Notes is lowered by both Rating Agencies and the Notes
are rated below an Investment Grade Rating by both Rating Agencies, in any case on any day during
the period (which period shall be extended so long as the rating of the Notes is under publicly
announced consideration for a possible downgrade by any of the Rating Agencies) commencing upon the
first public notice of the occurrence of a Change of Control or the Company’s intention to effect a
Change of Control and ending 60 days following the consummation of the Change of Control; provided
that a Rating Event otherwise arising by virtue of a particular reduction in rating shall not be
deemed to have occurred in respect of a particular Change of Control (and thus shall not be deemed
a Rating Event for purposes of the definition of Change of Control Triggering Event hereunder) if
any of the Rating Agencies making the reduction in rating to which this definition would otherwise
apply does not announce or publicly confirm or inform the Trustee in writing at its request that
the reduction was the result, in whole or in part, of any event or circumstance comprised of or
arising as a result of, or in respect of, the applicable Change of Control (whether or not the
applicable Change of Control shall have occurred at the time of the Rating Event).

     “S&P” means Standard & Poor’s Rating Services, a division of The McGraw-Hill Companies, Inc.,
and its successors.

     “Voting Stock” means, with respect to any specified “person” (as that term is used in Section
13(d)(3) of the Exchange Act) as of any date, the capital stock of such person that is at the time
entitled to vote generally in the election of the board of directors of such person.

     The Notes are not subject to any sinking fund.

     If an Event of Default with respect to the Notes shall occur and be continuing, the principal
of the Notes may be declared due and payable in the manner and with the effect provided in the
Indenture.

     The Indenture permits, with certain exceptions as therein provided, the amendment thereof and
the modification of the rights and obligations of the Company and the

6.950% Note due 2019

6

 

rights of the Holders of the Securities of each series to be affected under the Indenture at
any time by the Company and the Trustee with the consent of the Holders of not less than a majority
in aggregate principal amount of the Securities at the time Outstanding of each series affected
thereby. The Indenture also contains provisions permitting the Holders of specified percentages in
aggregate principal amount of the Securities of any series at the time Outstanding, on behalf of
the Holders of all Securities of such series, to waive compliance by the Company with certain
provisions of the Indenture and certain past defaults under the Indenture and their consequences.
Any such consent or waiver by the Holder of this Note shall be conclusive and binding upon such
Holder and upon all future Holders of this Note and of any Note issued upon the registration of
transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent
or waiver is made upon this Note.

     No reference herein to the Indenture and no provision of this Note or of the Indenture shall
alter or impair the right of the Holder of this Note, which is absolute and unconditional, to
receive payment of the principal of and, subject to certain qualifications in the Indenture,
interest on this Note at the times herein and in the Indenture prescribed and to institute suit for
the enforcement of any such payment unless the Holder of this Note shall have consented to the
impairment of such right.

     As provided in the Indenture and subject to certain limitations set forth therein, the
transfer of this Note may be registered in the Security Register, upon surrender of this Note for
registration of transfer at the office or agency of the Company in any place where the principal of
(and premium, if any) and interest on this Note are payable, duly endorsed by, or accompanied by a
written instrument of transfer in form satisfactory to the Company and the Security Registrar duly
executed by, the Holder hereof or by his attorney duly authorized in writing, and thereupon one or
more new Notes of this series and of any authorized denominations and of a like aggregate principal
amount and tenor, shall be issued to the designated transferee or transferees.

     The Notes are issuable only in registered form without coupons in denominations of $2,000 and
integral multiples of $1,000 in excess thereof. Subject to certain limitations therein set forth
in the Indenture and in this Note, the Notes are exchangeable for a like aggregate principal amount
of Notes of this series in different authorized denominations, as requested by the Holders
surrendering the same.

     No service charge shall be made for any such registration of transfer or for exchange of this
Note, but the Company or the Trustee may require payment of a sum sufficient to cover any tax or
other governmental charge that may be imposed in connection with any registration of transfer or
exchange of a Note, other than in certain cases provided in the Indenture.

     Prior to due presentment of this Note for registration of transfer, the Company, the Trustee
and any agent of the Company or the Trustee may treat the Person in whose name this Note is
registered as the owner hereof for all purposes, whether or not this Note be overdue, and neither
the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

6.950% Note due 2019

7

 

     The Indenture contains provisions whereby (i) the Company may be discharged from its
obligations with respect to the Notes (subject to certain exceptions) or (ii) the Company may be
released from its obligations under specified covenants and agreements in the Indenture, in each
case if the Company irrevocably deposits with the Trustee money or U.S. Government Obligations
sufficient to pay and discharge the entire indebtedness on all Notes of this series, and satisfies
certain other conditions, all as more fully provided in the Indenture.

     This Note shall be governed by and construed in accordance with the laws of the State of New
York.

     All terms used in this Note which are defined in the Indenture shall have the meanings
assigned to them in the Indenture.

     Unless the certificate of authentication hereon has been executed by or on behalf of the
Trustee under the Indenture by the manual signature of one of its authorized signatories, this Note
shall not be entitled to any benefits under the Indenture or be valid or obligatory for any
purpose.

6.950% Note due 2019

8

 

     IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

Dated: April 7, 2009

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	THE TJX COMPANIES, INC.
	 
	 	 	 	 	 	 	 	 
	Attest:

	 	 	 	 	 	By:	 	 
	 

	 	 
	 	 	 	 	 	 
	 

	 	Name:
	 	 	 	 	 	Name:
	 

	 	Title:
	 	 	 	 	 	Title:

6.950% Note due 2019

Signature Page

 

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

     This is one of the Securities of the series designated therein referred to in the
within-mentioned Indenture.

Dated: April 7, 2009

	 	 	 	 	 
	 	 	U.S. BANK NATIONAL
	 	 	ASSOCIATION, as
	 	 	Trustee
	 
	 	 	 	 
	 

	 	By:	 	 
	 

	 	 	 	 
	 

	 	 	 	Authorized Signatory

6.950% Note due 2019

Signature Page

 

 

ABBREVIATIONS

     The following abbreviations, when used in the inscription on the face of this instrument,
shall be construed as though they were written out in full according to applicable laws or
regulations.

	 	 	 	 	 	 	 	 	 
	TEN COM – as tenants	 	 	 	UNIF GIFT MIN ACT - . . .Custodian
	 

	 	          in common
	 	 	 	 	 	          (Cust) (Minor)
	TEN ENT - as tenants by	 	 	 	 	 	          Under Uniform Gifts to
	 

	 	          the entireties
	 	 	 	 	 	          Minor Act
	JT TEN - as joint tenants	 	 	 	 	 	 
	 

	 	          with right of	 	 	 	 	 	 
	 

	 	          survivorship and
	 	 	 	 	 	                                        
	 

	 	          not as tenants in
	 	 	 	 	 	          (State)
	 

	 	          common	 	 	 	 	 	 

Additional abbreviations may also be used though not in the above list.

	 	 	 
	 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto

	 	 
	

	 	 
	 

(Please insert Assignee’s legal name)

	 	 
	

	 	 
	 

(Please insert Social Security or other identifying number of Assignee)

	 	 
	

	 	 
	 

	 	 
	

	 	 
	 

(Please print or typewrite name and address including postal zip code of Assignee)

	 	 

the within Note of THE TJX COMPANIES, INC. and does hereby irrevocably constitute
and appoint                                         attorney to transfer the
said Note on the books of the Company, with full power of substitution in the
premises.

Dated:                                                            

	 	 	 	 	 
	 	 	Your Signature:
	 

	 	 	 	 
	 

	 	 	 	(Sign exactly as your name appears
	 

	 	 	 	on the face of this Note)
	                    
	 	 	 	 

[NOTICE: The signature to this assignment must correspond with the name as written upon the face
of the within instrument in every particular, without alteration or enlargement or any change
whatever.]

6.950% Note due 2019exv4w1

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    THIS
    AGREEMENT IS NOT AN OFFER WITH RESPECT TO ANY SECURITIES OR

    A SOLICITATION OF ANY KIND. SUCH AN OFFER OR SOLICITATION WILL
    BE

    MADE ONLY IN COMPLIANCE WITH ALL APPLICABLE SECURITIES
    LAWS
    

 

    RESTRUCTURING
    SUPPORT AGREEMENT

 

    RESTRUCTURING SUPPORT AGREEMENT, dated as of April 6, 2009, by
    and among EPIX Pharmaceuticals, Inc., a Delaware corporation
    (the “Company”), and
    (i) each of the undersigned beneficial owners of (or
    investment managers or advisors for accounts or funds that
    beneficially own) Notes (as defined below), and (ii) each
    other beneficial owner of (or investment manager or advisor for
    accounts or funds that beneficially own) Notes that executes a
    counterpart signature page to this Agreement after the date of
    this Agreement as provided herein (together with their
    applicable transferees, successors and assigns, each a
    “Noteholder” and, collectively, the
    “Noteholders”).

 

    WHEREAS, the Company has issued and outstanding
    $100 million aggregate principal amount of its
    3.00% Convertible Senior Notes due June 15, 2024 (the
    “Notes”) issued under that certain
    Indenture, dated as of June 7, 2004 by and between the
    Company and U.S. Bank, National Association, as Trustee, as
    amended by the First Supplemental Indenture, dated as of
    January 5, 2001 (as amended, the
    “Indenture”);

 

    WHEREAS, in the Exchange Offer (as defined below) the Company
    intends to offer to exchange (i) a cash payment of $180.00,
    (ii) 3391

    shares of the Company’s common stock, par value $0.01 per
    share (the “Common Stock”), and
    (iii) one (1) contingent value right
    (“Contingent Value Right” or
    “CVR”) which represents the contractual right
    to the consideration set forth in the Contingent Value Rights
    Agreement (as defined below), for each $1,000 of aggregate
    principal amount outstanding of its Notes;

 

    WHEREAS, concurrently with the Exchange Offer, in the Consent
    Solicitation (as defined below) the Company intends to solicit
    consents from the holders of the outstanding Notes to adopt the
    Proposed Amendments (as defined below) to the Indenture to
    modify certain provisions of the Indenture that may be amended
    by the written consent of holders of a majority in aggregate
    principal amount of the Notes (these proposed amendments to the
    Indenture, together with the agreements giving effect to such
    amendments, the “Proposed Amendments”).
    The Company is not offering to pay any separate or additional
    payment for the consents to the Proposed Amendments;

 

    WHEREAS, the Company and the Noteholders have engaged in good
    faith negotiations with the objective of consummating the
    Exchange Offer, the Consent Solicitation and related
    transactions, including (i) the issuance of the Common
    Stock in the Exchange Offer and (ii) the approval of the
    Proposed Amendments substantially in the form set forth in
    Exhibit A hereto, as the foregoing may
    be amended in accordance with the terms hereof; and

 

    WHEREAS, the Company and the Noteholders desire that the Company
    conduct the Exchange Offer and the Consent Solicitation as soon
    as reasonably practicable.

 

    NOW, THEREFORE, in consideration of the mutual covenants and
    agreements set forth in this Agreement, and for other good and
    valuable consideration, the receipt and sufficiency of which are
    hereby acknowledged, each of the parties signatory to this
    Agreement hereby agrees as follows:

 

    1.  Definitions.   Capitalized
    terms used and not defined in the body of this Agreement have
    the meaning ascribed to them in the respective Annex hereto, and
    the following terms shall have the following meanings:

 

    “Affiliate” means, with respect to any Person,
    any other Person that directly or indirectly through one or more
    intermediaries, controls, is controlled by, or is under common
    control with, such Person. For purposes of this definition,
    “control” of a Person means the power, directly or
    indirectly, to direct or cause the direction of the

 

 

    1 To

    be determined by using a price equal to the arithmetic average
    of the Volume Weighted Average Price of the Common Stock for the
    fifteen (15) trading day period ending on the trading day
    immediately prior to signing this Agreement.

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    management and policies of such Person whether through holding
    beneficial ownership interests in such other Person, by contract
    or otherwise.

 

    “Agreement” means this Restructuring Support
    Agreement, including the Schedules and Annexes hereto.

 

    “Business Day” means any day that is not a
    Saturday, a Sunday or a day on which banks in the State of New
    York are generally closed for business.

 

    “Buyer” means Lantheus Medical Imaging, Inc.

 

    “Buyer Parties” mean the Buyer and its present
    or former officers, directors, agents, employees, shareholders
    and affiliates, in each case, in their capacity as such, and the
    successors and assigns of any of the foregoing.

 

    “Buyer Party Provisions” means, collectively,
    Sections 3(b), 5(c), 10, 12, 16, 17, 18, 19, 20, 25 and 26
    and any applicable definitions of the capitalized terms used in
    the foregoing sections, in each case, to the extent and solely
    to the extent that such provisions benefit, or otherwise relate
    to the rights of, the Buyer Parties contained in Section 10.

 

    “Commission” means the Securities and Exchange
    Commission, or any other federal agency at the time
    administering the Securities Act or the Exchange Act.

 

    “Consent Solicitation” means that certain
    consent solicitation described in the Draft Schedule TO.

 

    “Draft Schedule TO” means that certain
    draft Schedule TO of the Company, a copy of which is
    attached hereto.

 

    “Exchange Act” means the Securities Exchange
    Act of 1934, and any successor to such statute, and the rules
    and regulations of the Commission issued under such Act, as they
    each may, from time to time, be amended and in effect.

 

    “Escrow Agreement” means that certain Escrow
    Agreement, dated as of the date hereof, by and between the
    Company and U.S. Bank, National Association, as Escrow
    Agent.

 

    “Exchange Documents” means this Agreement and
    any other documents to be executed and delivered in connection
    with the consummation of the Exchange Offer.

 

    “Exchange Offer” means that certain exchange
    offer described in the Draft Schedule TO.

 

    “Person” means any individual, partnership,
    corporation, limited liability company, association, trust,
    joint venture, unincorporated organization, governmental unit or
    other entity.

 

    “Product” means the injectable intravascular
    magnetic resonance angiography contrast agent currently known as
    Vasovist®.

 

    “Proposed Amendments” means those proposed
    amendments to the Indenture set forth on
    Exhibit A hereto, together with the
    indenture supplement and any other agreements giving effect to
    such amendments.

 

    “Purchase Agreement” means that certain Asset
    Purchase Agreement, dated as of the date hereof, a copy of which
    is attached hereto as Exhibit B,
    between the Company and the Buyer, pursuant to which, among
    other things, the Company has agreed to sell, transfer and
    assign to the Buyer the Purchased Assets.

 

    “Purchased Assets” means, collectively, the
    Product, as well as all intellectual property, regulatory
    filings, data, information, records, contracts, claims, and
    other materials related to the Product and as more specifically
    set forth in the Purchase Agreement.

 

    “Required Noteholders” means holders of
    outstanding Notes representing at least seventy-five percent
    (75%) in aggregate principal amount of the Notes.

 

    “Securities Act” means the Securities Act of
    1933, as amended, and the rules and regulations promulgated
    thereunder.

    

    2

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    “Tender Notes” means the face amount of Notes
    to be tendered by each Noteholder in the Exchange as set forth
    in Schedule A hereto.

 

    “Transfer” means to, directly or indirectly,
    (i) sell, assign or transfer, (ii) pledge, encumber,
    create any participation or grant any proxy or option, in each
    case such as would prevent, preclude, hinder or delay the
    ability of the Person engaging in such Transfer from fulfilling
    any of such Person’s obligations under this Agreement,
    including, without limitation, Section 3 hereof, or
    (iii) enter into any agreement, commitment or other
    arrangement to do any of the foregoing. Notwithstanding the
    foregoing, the parties acknowledge that certain Noteholders may
    hold the Tender Notes in margin accounts and may continue to so
    hold; provided that in no event shall this affect such
    Noteholders obligations under the terms of this Agreement.

 

    “Transaction Documents” means the Exchange
    Documents, the Registration Rights Agreement, the Contingent
    Value Rights Agreement and the Proposed Amendments.

 

    2.  Agreements of the Company.

 

    (a) Subject to the terms and conditions of this Agreement,
    the Company agrees as follows:

 

    (i)  Commencement of the Exchange Offer and the
    Consent Solicitation:  The Company shall
    commence the Exchange Offer and the Consent Solicitation within
    two (2) Business Days of the date hereof, pursuant to which
    (A) with respect to the Exchange Offer, the Company will
    offer to exchange for each $1,000 in principal amount of Notes
    (including all accrued but unpaid interest thereon through the
    consummation of the Exchange Offer) (1) $180.00 in cash,
    (2) 339 shares of Common Stock and (3) one Contingent
    Value Right (the consideration referenced in clauses (1),
    (2) and (3), the “Exchange
    Consideration”), which shares of Common Stock and
    CVRs will be issued in a transaction exempt from registration
    pursuant to Section 3(a)(9) of the Securities Act, and
    assuming that all Notes are tendered in the Exchange Offer, will
    result in an aggregate cash payment by the Company of
    $18,000,000 (including all accrued and unpaid interest through
    the consummation of the Exchange Offer), the issuance of
    33,900,000 shares of Common Stock and issuance of 100,000
    CVRs and (B) with respect to the Consent Solicitation, the
    Company will solicit consents from the holders of the
    outstanding Notes to adopt the Proposed Amendments. For the
    avoidance of doubt, the Company and the Noteholders acknowledge
    and agree that no portion of the Exchange Consideration is in
    payment of any accrued and unpaid interest on the Notes.

 

    (ii)  Expiration of the Exchange Offer and the
    Consent Solicitation:  The Exchange Offer and
    the Consent Solicitation shall expire on the date which is
    twenty (20) Business Days from the date of commencement of
    the Exchange Offer and the Consent Solicitation, provided that
    the Company may extend such expiration date with the written
    consent of the Required Noteholders.

 

    (iii)  Exchange Offer Minimum Tender
    Condition:  The Company may not consummate the
    Exchange Offer or the Proposed Amendments unless holders of at
    least ninety-three percent (93%) of the aggregate principal
    amount of Notes shall have (a) validly tendered and not
    withdrawn their Notes in the Exchange Offer and (b) consent
    to the Proposed Amendments, provided that, subject to
    Section 4, such conditions may be modified by the Company
    with the written consent of the Required Noteholders or if and
    as necessary in order to comply with applicable law.

 

    (iv)  Affiliates’ Registration Rights
    Agreement:  In the event the Exchange Offer is
    consummated, the Company will enter into a Registration Rights
    Agreement substantially in the form of
    Exhibit C attached hereto (the
    “Registration Rights Agreement”) with
    any requesting holders of Notes who may be deemed affiliates (as
    defined under Rule 144 of the Securities Act) of the
    Company following the consummation of the Exchange Offer.

 

    (v)  Contingent Value Rights
    Agreement.  Immediately prior to the
    consummation of the Exchange Offer, the Company will enter into
    a Contingent Value Rights Agreement substantially in the form of
    Exhibit D attached hereto (the
    “Contingent Value Rights Agreement”)
    with U.S. Bank, National Association, as rights agent, in
    favor of each tendering holder of Notes.

 

    (vi)  Vasovist
    Transaction:  Concurrently with the execution
    of this Agreement, the Company shall provide to Schulte
    Roth & Zabel LLP, as counsel to the Noteholders, fully
    executed copies of the Purchase Agreement.

    

    3

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    (vii)  Deposit of
    Proceeds.  The Company shall direct the Buyer
    to deposit with U.S. Bank, National Association, as Escrow
    Agent (the “Escrow Agent”), on the date
    hereof in immediately available funds, the full amount of the
    net proceeds to be received by the Company pursuant to the
    Purchase Agreement, which amount shall not be less than
    $17,000,000 (the “Net Proceeds”), and as
    soon as practicable, but in no event later than three
    (3) Business Days after the date hereof, the Company shall
    deposit with the Escrow Agent in immediately available funds an
    amount equal to $18,000,000 less the Net Proceeds. The amounts
    deposited with the Escrow Agent pursuant to this
    Section 2(a)(vii) will be used for the payment of the cash
    portion of the Exchange Consideration to be disbursed as set
    forth in Escrow Agreement.

 

    (b) Notwithstanding anything to the contrary in this
    Agreement, to the extent (i) in the Exchange Offer the
    Company pays any consideration to any tendering holder of Notes
    in addition to the Exchange Consideration, each Noteholder shall
    receive such additional consideration in amount proportional to
    the principal amount of Tender Notes tendered by such Noteholder
    and/or
    (ii) in the Consent Solicitation the Company pays any
    consideration in exchange for any consent (including, without
    limitation, any early consent fee), each Noteholder shall
    receive such consideration in amount proportional to the
    principal amount of Tender Notes to which such Noteholder has
    given consent hereunder.

 

    (c) In the event of a stock split, stock dividend or
    distribution, or any change in the Common Stock by reason of a
    stock split, reverse stock split, recapitalization, combination,
    reclassification, readjustment, exchange of shares or the like,
    the term “Exchange Consideration” shall
    be deemed to refer to and include such shares as well as all
    such stock dividends and distributions and any securities into
    which or for which any or all of such shares may be changed or
    exchanged.

 

    3.  Agreements of the
    Noteholders.  Subject to the terms and
    conditions of this Agreement:

 

    (a) Each Noteholder agrees with the Company, in connection
    with the consummation of the Exchange Offer and the Consent
    Solicitation and when solicited in accordance with applicable
    securities law, to:

 

    (i) tender (or cause to be tendered) its Tender Notes in
    exchange for the amount of Exchange Consideration applicable to
    such Tender Notes on or prior to the date on which the Exchange
    Offer expires, in accordance with the terms thereof;

 

    (ii) consent to adopt the Proposed Amendments on or prior
    to the date on which the Consent Solicitation expires, in
    accordance with the terms thereof; and

 

    (iii) not withdraw or revoke (or cause not to be withdrawn
    or revoked) any of the foregoing unless and until this Agreement
    is terminated in accordance with its terms.

 

    (b) Each Noteholder agrees, so long as this Agreement
    remains in effect, not to Transfer any of its Tender Notes, in
    whole or in part, unless the transferee agrees in writing to be
    bound by the terms of this Agreement to the same extent as the
    Tender Notes of a Noteholder hereunder. In the event that any
    Noteholder Transfers any of the Tender Notes owned or
    beneficially held as of the date hereof, as a condition
    precedent to such Transfer, such Noteholder agrees to cause the
    transferee to execute and deliver an acknowledgement, in the
    form attached hereto as Exhibit E,
    whereby such transferee agrees to be bound by the terms of this
    Agreement. Such acknowledgement shall be delivered to the
    Company immediately following the consummation of such Transfer,
    and the Company shall deliver such acknowledgement to the Buyer
    Parties immediately following the receipt thereof. Any Transfer
    of Tender Notes to a person not party to this Agreement in
    violation of this Section 3(b) shall be deemed void.
    Notwithstanding the foregoing, any Noteholder may Transfer its
    Tender Notes to an Affiliate or another Noteholder so long as
    (i) such Tender Notes constitute Additional Notes pursuant
    to Section 23 hereof and, as a result, become
    subject to the terms of this Agreement, and (ii) the
    transferring Noteholder delivers written notice of such Transfer
    to the Company prior to or within two (2) Business Days
    following such Transfer. Notwithstanding the foregoing, the
    parties acknowledge that certain Noteholders may hold Tender
    Notes in margin accounts and may continue to so hold; provided
    that in no event shall this affect such Noteholders’
    obligations under the terms of this Agreement.

    

    4

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    (c) So long as this Agreement remains in effect, no
    Noteholder will enter into any voting agreement with any person
    or entity with respect to any of its Tender Notes, grant any
    person or entity any proxy (revocable or irrevocable) or power
    of attorney with respect to any of its Tender Notes, deposit any
    of its Tender Notes in a voting trust or otherwise enter into
    any agreement or arrangement with any person or entity limiting
    or affecting such Noteholder’s legal power, authority or
    right to vote its Tender Notes and agree to the amendments to
    the terms of the Exchange Offer, the Consent Solicitation or
    this Agreement.

 

    (d) Subject to the provisions of Section 28,
    each Noteholder agrees that it will permit public disclosure,
    including in a press release and in the documents filed with the
    Commission for the Exchange Offer and the Consent Solicitation,
    of this Agreement, including, but not limited to, the
    commitments contained in this Section 3; provided,
    however, that such Noteholders and its counsel shall be given a
    reasonable opportunity to review and comment on any such
    disclosure, and the Company shall give reasonable consideration
    to any comments made by the Noteholders and their counsel. The
    Company shall provide the Noteholders and their counsel with
    (i) any comments or other communications, whether written
    or oral, that the Company or its counsel may receive from time
    to time from the Commission or its staff with respect to the
    Exchange Documents promptly after receipt of those comments or
    other communications and (ii) a reasonable opportunity to
    participate in the response of the Company to those comments
    that relate in any material respect to any of the Noteholders
    and to provide comments on that response (to which reasonable
    consideration shall be given).

 

    (e) Each Noteholder further agrees, until the earlier of
    the consummation of the Exchange Offer and Consent Solicitation
    or the termination of this Agreement that it will not:

 

    (i) object to, or otherwise commence or support any
    proceeding or action to oppose, the Exchange Offer, the Consent
    Solicitation or the other actions of the Company contemplated by
    this Agreement and shall not take any action or otherwise
    commence or support any action or proceeding that would
    constitute a breach of any of its representations, warranties
    and agreements set forth herein or would unreasonably delay the
    consummation of the Exchange Offer or the Consent Solicitation
    including, but not limited to (A) the filing of an
    involuntary petition against the Company, or (B) taking any
    action in connection with any default or Event of Default under
    and as defined in the Indenture; or

 

    (ii) directly or indirectly seek, solicit, support, or
    encourage any other plan, sale, proposal, or offer of winding
    up, liquidation, reorganization, merger, amalgamation,
    consolidation, dissolution or restructuring of the Company.

 

    (f) In addition, for so long as this Agreement has not been
    terminated, each Noteholder shall refrain, in its capacity as a
    Noteholder of Tender Notes, from directly or indirectly taking
    any action, or permitting any of its affiliates, representatives
    or agents from taking any action, that would materially impede,
    interfere with, delay, postpone, discourage or materially and
    adversely affect the consummation of the Exchange Offer and the
    Consent Solicitation.

 

    4.  Amendments to the Exchange Offer and the
    Consent Solicitation.

 

    (a) The Company shall not:

 

    (i) amend, modify, alter or waive any of the material terms
    and conditions of the Exchange Offer or the Consent Solicitation
    in a manner adverse to the Noteholders or otherwise reduce the
    amount of cash or Common Stock to be paid in the Exchange Offer
    per $1,000 principal amount of tendered Notes or otherwise take
    or fail to take any action that would reasonably be expected to
    impede, interfere with, delay, postpone, discourage or
    materially and adversely affect the timely consummation of the
    Exchange Offer or the Consent Solicitation;

 

    (ii) extend the Exchange Offer or the Consent Solicitation
    except to the extent required by applicable law, without the
    prior written consent of the Required Noteholders;

 

    (iii) modify the valid tender of the holders that hold, in
    the aggregate, at least ninety-three percent (93%) of the
    outstanding principal amount of the Notes in the Exchange Offer
    or the consent of the holders that hold, in the

    

    5

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    aggregate, at least ninety-three percent (93%) of the
    outstanding principal amount of the Notes in the Consent
    Solicitation, without the prior written consent of the Required
    Noteholders; or

 

    (iv) reduce the percentage in principal amount of Notes set
    forth in the definition of “Required Holders” that is
    required for the consent or waiver of any provision of this
    Agreement.

 

    (b) Except as provided in Section 4(a), and to
    the extent not requiring extension of the Exchange Offer or the
    Consent Solicitation under applicable law, the Company may waive
    any of the conditions to the Exchange Offer or the Consent
    Solicitation.

 

    5.  Termination of Agreement.

 

    (a) Notwithstanding anything to the contrary set forth in
    this Agreement, unless the Exchange Offer and the Consent
    Solicitation have been consummated as provided in this
    Agreement, this Agreement and all of the obligations and
    undertakings of the parties set forth in this Agreement shall
    terminate and expire upon the earliest to occur of:

 

    (i) mutual written consent of the Company and each
    Noteholder;

 

    (ii) without any action by the Company or any Noteholder,
    if the Exchange Offer and the Consent Solicitation are not
    consummated on or before May 11, 2009, provided that no
    party may terminate this Agreement under this clause (ii)
    if the failure to consummate the Exchange Offer or the Consent
    Solicitation is the result of the material breach of this
    Agreement by such party;

 

    (iii) by the Required Noteholders, if the Exchange Offer
    and the Consent Solicitation are not commenced on or before
    April 9, 2009;

 

    (iv) by the Required Noteholders, if the Company breaches
    the provisions of Section 4;

 

    (v) without action by the Company or any Noteholder, if the
    Company commences, or an order for relief is entered against it,
    in a case under Title 11 of the United States Code or the
    Company shall otherwise be adjudicated bankrupt or insolvent
    under applicable law;

 

    (vi) without any action by the Company or any Noteholder,
    if the Company makes an assignment for the benefit of creditors
    or any proceeding relating to the Company under any
    reorganization, arrangement, insolvency, readjustment of debt,
    dissolution, liquidation or similar proceeding of any
    jurisdiction is filed or commenced against the Company; or

 

    (vii) without any action by either the Company or any
    Noteholder, if (1) the Exchange Offer shall expire or be
    terminated without the exchange of the requisite Notes and
    (2) the Consent Solicitation shall expire or be terminated
    without the Proposed Amendments being adopted.

 

    (b) Notwithstanding the foregoing or any other provision of
    this Agreement, neither the termination of this Agreement nor
    any other circumstance shall relieve a party from liability for
    the willful breach of its obligations hereunder.

 

    (c) The provisions of this Section 5(c),
    Sections 10, 12, 16, 17, 18, 19, 20, 25 and 26, and any
    applicable definition of the capitalized terms used in any of
    the foregoing sections shall survive any termination of this
    Agreement.

 

    6.  Representations, Warranties and
    Covenants.

 

    (a) The Company represents and warrants to each Noteholder,
    and each Noteholder represents and warrants to the Company as
    follows:

 

    (i) if an entity, it is duly organized, validly existing
    and in good standing under the laws of the jurisdiction of its
    organization and has all requisite corporate, partnership or
    other power and authority to enter into each Transaction
    Document to which it is a party and to carry out the
    transactions contemplated by, and perform its respective
    obligations under, each Transaction Document to which it is a
    party;

    

    6

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    (ii) the execution, delivery and performance by it of each
    Transaction Document to which it is a party does not and shall
    not (A) violate any provision of law, order, rule or
    regulation applicable to it or any of its affiliates or its
    certificate of incorporation or bylaws or other organizational
    documents or those of any of its subsidiaries or
    (B) conflict with, result in the breach of or constitute
    (with due notice or lapse of time or both) a default under any
    material contractual obligations to which it or any of its
    affiliates is a party or under its certificate of incorporation,
    bylaws or other governing instruments;

 

    (iii) the execution, delivery and performance by it of each
    Transaction Document to which it is a party does not and shall
    not require any registration or filing with, the consent or
    approval of, notice to, or any other action with respect to, any
    Federal, state or other governmental authority or regulatory
    body, except for (A) the registration under the Securities
    Act contemplated by the Registration Rights Agreement and such
    consents, approvals, authorizations, registrations or
    qualifications as may be required under the state securities or
    Blue Sky laws in connection with the issuance of the Exchange
    Shares, (B) the filing with the Commission of a Tender
    Offer Statement on Schedule TO with respect to the Exchange
    Offer and the Consent Solicitation, including the exhibits
    thereto, and (C) such other filings as may be necessary or
    required by the Commission;

 

    (iv) each Transaction Document to which it is a party has
    been duly authorized, executed and delivered and, assuming the
    due execution and delivery of such Transaction Document by each
    of the other parties thereto, each such Transaction Document is
    the legally valid and binding obligation of it, enforceable
    against it in accordance with its terms, except as
    enforceability may be limited or affected by applicable
    bankruptcy, insolvency, moratorium, reorganization or other laws
    of general application relating to or affecting creditors’
    rights generally; and

 

    (v) it has been represented by counsel in connection with
    the Transaction Documents and the transactions contemplated by
    the Transaction Documents.

 

    (b) Each of the Noteholders further represents and warrants
    to the Company that:

 

    (i) as of the date of this Agreement, such Noteholder
    (together with its Affiliates) is the beneficial owner of, or
    the investment adviser or manager for the beneficial owners of,
    the aggregate principal amount of Tender Notes set forth
    opposite such Noteholder’s name on
    Schedule A hereto, which represents
    all of the Notes held by such Noteholder (other than with
    respect to the Notes representing an aggregate principal amount
    of $655,000 held by certain discretionary accounts managed by
    Loomis, Sayles & Company, L.P. which Loomis,
    Sayles & Company, L.P. agrees to use commercially
    reasonable efforts to tender in the Exchange), with the
    requisite power and authority to vote and dispose of such Tender
    Notes, and such Tender Notes are owned free and clear of any
    liens, encumbrances, equities or claims, other than those under
    securities laws or any ordinary course claims, including,
    without limitation, in connection with pledges in connection
    with bona fide margin accounts or other loan or financing
    agreement secured by the Tender Notes;

 

    (ii) as of the date of this Agreement and through the date
    of acquisition of the Tender Notes pursuant to the Exchange
    Offer, such Noteholder has full legal power, authority and right
    (A) to exchange its Tender Notes then held of record or
    beneficially owned by it and (B) to consent to the Proposed
    Amendments with respect to its Tender Notes then held of record
    or beneficially owned by it, in each case without the consent,
    approval of, or any other action on the part of, any other
    person or entity; and such Noteholder has not entered into any
    voting agreement (other than this Agreement) with any person or
    entity with respect to any of its Tender Notes, granted to any
    person or entity any of its Tender Notes, deposited any of its
    Tender Notes in a voting trust or entered into any arrangement
    or agreement with any person or entity limiting or affecting its
    legal power, authority or right to vote such Tender Notes on any
    matter; and

 

    (iii) such Noteholder has reviewed, or has had the
    opportunity to review, with the assistance of professional and
    legal advisors of its choosing, sufficient information necessary
    for such Noteholder to decide to (A) exchange its Tender
    Notes pursuant to the Exchange Offer and (B) consent to the
    Proposed Amendments pursuant to the Consent Solicitation.

    

    7

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    (c) The Company further represents, warrants, covenants and
    agrees to the Noteholders as follows:

 

    (i) as of the date of this Agreement, the capitalization of
    the Company is as set forth in the Company’s Annual Report
    on Form 10-K
    filed with the Commission on March 13, 2009 (the
    “Annual Report”), other than
    (A) exercises of outstanding options, warrants and other
    rights after the date set forth in the Annual Report and
    (B) grants of options, warrants and other rights after the
    date set forth in the Annual Report;

 

    (ii) that the Exchange Shares are duly authorized and, upon
    issuance will be duly and validly issued and free from all
    taxes, liens and charges with respect to the issue thereof and
    the Exchange Shares shall be fully paid and nonassessable;

 

    (iii) that the Company has reserved from its duly
    authorized capital stock the maximum number of Exchange Shares
    issuable in the Exchange Offer;

 

    (iv) from and after the date hereof until the consummation
    or termination of the Exchange Offer and the Consent
    Solicitation, the Company shall not issue any additional shares
    of Common Stock, or any options, warrants and other rights
    (including pursuant to convertible securities) to acquire Common
    Stock or shares of any other capital of the Company or any
    subsidiary of the Company, except (A) pursuant to options,
    warrants and other rights (including pursuant to convertible
    securities) outstanding on the date of this Agreement, and
    (B) for grants or awards under the Company’s existing
    equity incentive plan in accordance with the Company’s past
    practice;

 

    (v) the Company shall comply with all applicable law in
    connection with the Exchange Offer and Consent Solicitation;

 

    (vi) assuming that the information set forth in the
    questionnaire, in the form of Exhibit F
    attached hereto (the
    “Questionnaire”) delivered by each
    Noteholder to the Company on or prior to the date hereof (the
    “Completed Questionnaire”) is true and
    correct as of the consummation of the Exchange Offer,
    (A) such Noteholder will not be an affiliate (as defined
    under Rule 144 of the Securities Act) of the Company
    following the consummation of the Exchange Offer, (B) the
    Exchange Shares will be issued to such Noteholder without any
    restrictive legend by electronic delivery at the balance account
    at The Depository Trust Company specified by such
    Noteholder and (C) subject to the provisions of
    Section 9 below, to the Company’s knowledge the
    Exchange Shares will be freely saleable without restriction or
    limitation pursuant to Rule 144 and without the requirement
    to be in compliance with Rule 144(c)(1) (or any successor
    thereto) promulgated under the Securities Act; and

 

    (vii) the Company shall cause all shares of Common Stock
    issued in the Exchange Offer to be listed on each securities
    exchange or other securities market, if any, on which the Common
    Stock is then listed.

 

    (d) For the purposes of Rule 144 of the Securities
    Act, the Company acknowledges that the holding period of the
    Exchange Shares may be tacked onto the holding period of the
    Tender Notes, and the Company agrees not to take any position
    contrary to this Section 6(d). The Company agrees to
    take all actions, including, without limitation, the issuance by
    its legal counsel of any necessary legal opinions, necessary to
    issue the Exchange Shares without restriction and not containing
    any restrictive legend without the need for any action by any
    Noteholder provided that such Noteholder’s Completed
    Questionnaire is true and correct as of the consummation of the
    Exchange Offer.

 

    (e) The Company shall use its commercially reasonable
    efforts to file the reports required to be filed by it under the
    Securities Act and the Exchange Act in a timely manner and, if
    at any time the Company is not required to file such reports, it
    will, upon the written request of any Noteholder, make publicly
    available other information as necessary to permit sales of such
    Noteholder’s Exchange Shares pursuant to Rule 144.

 

    7.  Disclosure of Transactions and Other
    Material Information.  On or before
    9:30 a.m., New York City time, on the second
    (2nd)

    Business Day following the date of this Agreement, the Company
    shall issue a press release and file a Current Report on
    Form 8-K
    describing the terms of the transactions contemplated by the
    Transaction Documents and the Purchase Agreement in the form
    required by the Exchange Act and attaching the material
    transaction documents (including, without limitation, this
    Agreement, the Registration Rights Agreement, the Contingent
    Value Rights Agreement, the Proposed Amendments and the Purchase
    Agreement as exhibits to such filing (including all attachments,
    the

    

    8

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    “8-K
    Filing”). The Company acknowledges and agrees that from
    and after the filing of the
    8-K Filing
    with the SEC, no Noteholder shall be in possession of any
    material, nonpublic information received from the Company, any
    of its Subsidiaries or any of their respective officers,
    directors, employees or agents. The Company shall not, and shall
    cause each of its Subsidiaries and its and each of their
    respective officers, directors, employees and agents, not to,
    provide any Noteholder with any material, nonpublic information
    regarding the Company or any of its Subsidiaries from and after
    the filing of the
    8-K Filing
    with the Commission without the express written consent of such
    Noteholder. Subject to the foregoing and Section 28,
    neither the Company, nor its Subsidiaries shall issue any press
    releases or any other public statements with respect to the
    transactions contemplated hereby; provided, however, that the
    Company shall be entitled, without the prior approval of any
    Noteholder, to make any press release or other public disclosure
    with respect to such transactions (i) in substantial
    conformity with the
    8-K Filing
    and contemporaneously therewith and (ii) as is required by
    applicable law and regulations. Without the prior written
    consent of such Noteholder, and except as contemplated by the
    preceding sentence, neither the Company nor any of its
    Subsidiaries or affiliates shall disclose the name of a
    Noteholder in any announcement or release.

 

    8.  Reserved.

 

    9.  Lock-Up.  Each Noteholder
    hereby agrees that from the date of consummation of the Exchange
    Offer and ending on the date that is ninety (90) days after
    the date of consummation of the Exchange Offer (the
    “Lock-Up
    Period”), such Noteholder will not, without the
    prior written consent of the Company, directly or indirectly,
    (i) offer, sell, assign, transfer, pledge, contract to
    sell, or otherwise dispose of, any shares of Common Stock issued
    to such Noteholder in connection with the Exchange Offer (such
    shares, the “Exchange Shares”), or
    (ii) enter into any swap, hedge or similar agreement or
    arrangement that transfers, in whole or in part, the economic
    risk of ownership of the Exchange Shares; provided, however,
    that (A) a Noteholder shall be permitted to transfer its
    Exchange Shares without obtaining such prior consent to any
    Affiliate of the Noteholder or to any holder of equity interests
    in, or any general or limited partner or member of, such
    Noteholder, provided that prior to any such transfer any such
    transferee agrees in writing to be bound by the terms of this
    Section 9, (B) a Noteholder shall be permitted
    to transfer its Exchange Shares pursuant to a merger, tender
    offer or exchange offer or other business combination,
    acquisition of assets or similar transaction or change of
    control of the Company and (C) a Noteholder shall receive
    the benefits of any release or modification of this
    Section 9 for any other Noteholder subject to this Section.
    Notwithstanding the foregoing, each Noteholder shall be
    permitted to transfer its respective Exchange Shares in the
    following amounts and on the following dates during the
    Lock-Up
    Period: (1) beginning thirty (30) days after the
    consummation of the Exchange Offer, up to 33.33% of such
    Exchange Shares and (2) beginning sixty (60) days
    after the consummation of the Exchange Offer, up to 66.66% of
    such Exchange Shares. Notwithstanding anything to the contrary
    in this Agreement, the Company shall be entitled to take all
    reasonable and necessary actions to enforce compliance with the
    provisions of this Section 9, including, without
    limitation, the issuance of a stop-transfer instruction.

 

    10.  Consent and Acknowledgement Regarding
    Vasovist Transaction.

 

    (a) Each Noteholder hereby acknowledges and agrees that it
    will not take a position contrary to the position that the sale
    by the Company of the Purchased Assets (as defined in the
    Purchase Agreement) and the consummation of the transactions
    contemplated by the Purchase Agreement (collectively, the
    “Vasovist Transaction”) does not
    (i) constitute a Change in Control (as defined in the
    Indenture) or a Designated Event (as defined in the Indenture)
    under the Indenture, the Notes or any related documents
    (collectively, the “Indenture
    Documents”), (ii) constitute a breach of, and
    is not otherwise in contravention of, any provision of the
    Indenture Documents (including, without limitation,
    Sections 7.1 and 13.1 of the Indenture), or
    (iii) require or result in an obligation to offer to
    repurchase or assume the indebtedness relating to or evidenced
    by the Indenture Documents as a result of the consummation of
    the Vasovist Transaction.

 

    (b) Each Noteholder hereby acknowledges that it has no
    reason to believe based on the provisions of the Purchase
    Agreement that it has, and shall not assert, any claims, causes
    of action, rights or demands whatsoever, or of any kind or
    nature, whether known or unknown, actual or potential
    (collectively, “Claims”) against the
    Buyer Parties under the Indenture Documents, or under any
    applicable law or in equity, including without limitation, in
    the nature of any

    

    9

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    fraudulent conveyance, preference claim or similar Claims,
    arising from or related to the consummation of the Vasovist
    Transaction.

 

    (c) Each Noteholder (on behalf of itself, each of its
    affiliates and each successor and assign of the foregoing)
    hereby fully, finally, absolutely, unconditionally and
    irrevocably releases, acquits and forever discharges each of the
    Buyer Parties from any and all past, present and future claims,
    actions, causes of action, suits, rights, obligations, promises,
    liabilities, debts, agreements, damages, injuries, losses,
    costs, expenses (including legal fees and disbursements) and
    demands whatsoever, of any kind, character, description or
    nature whatsoever, whether known or unknown to such Noteholder,
    suspected or unsuspected, reported or unreported, fixed or
    contingent, accrued or unaccrued, liquidated or unliquidated,
    foreseen or unforeseen, actual or potential, whether arising
    prior to, as of, or following, the consummation of the Vasovist
    Transaction, whether grounded in law or equity or sounding in
    tort or contract or otherwise (including without limitation in
    the nature of any fraudulent conveyance, preference claim or
    similar claims), that such Noteholder ever had, owned or held or
    claimed to have, own or hold, now has, owns or holds or claims
    to have, own or hold, or in the future may have, own or hold or
    claim to have, own, or hold, against any of the Buyer Parties,
    arising directly or indirectly out of, based upon, or in any way
    related to or in connection with, the Vasovist Transaction.

 

    11. Good Faith.  Each of the
    signatories to this Agreement agrees to cooperate in good faith
    with each other to facilitate the performance by the parties of
    their respective obligations hereunder and the purposes of this
    Agreement.

 

    12.  Amendments and
    Modifications.  Except as otherwise expressly
    provided in this Agreement, this Agreement shall not be amended,
    changed, supplemented, waived or otherwise modified or
    terminated except by instrument in writing signed by each of the
    parties hereto. Notwithstanding the foregoing, Section 10,
    Section 25 (other than the first sentence thereof) and this
    sentence shall not be amended, modified or supplemented without
    the prior written consent of the Buyer Parties, which consent
    may be withheld or delayed for any reason in their sole
    discretion, and none of the other Buyer Party Provisions shall
    be amended, modified or supplemented without the prior written
    consent of the Buyer Parties solely to the extent that such
    amendments, modifications or supplements would adversely affect
    the Buyer Parties’ rights to enforce Section 10 of
    this Agreement.

 

    13.  No Waiver; Release Upon Consummation of the
    Exchange Offer and the Consent
    Solicitation.  Each of the signatories to this
    Agreement expressly acknowledges and agrees that, except as
    expressly provided in this Agreement, nothing in this Agreement
    is intended to, or does, in any manner waive, limit, impair or
    restrict the ability of any party to this Agreement to protect
    and preserve all of its rights, remedies and interests,
    including, without limitation, with respect to its claims
    against and interests in the Company. In connection with the
    Exchange Offer and the Consent Solicitation, and upon
    consummation thereof, the holders of Notes who tender Notes in
    the Exchange Offer and have such Notes so tendered accepted for
    payment therefor by the Company shall, at such time, release
    claims against the Company and others Persons as and to the
    extent set forth in the Exchange Offer and the Consent
    Solicitation materials in respect of their Tender Notes.

 

    14.  Further Assurances.  Each
    of the signatories to this Agreement hereby further covenants
    and agrees to execute and deliver all further documents and
    agreements and take all further action that may be reasonably
    necessary or desirable in order to enforce and effectively
    implement the terms and conditions of this Agreement, the
    Exchange Offer and the Consent Solicitation.

 

    15.  Complete Agreement.  The
    Transaction Documents, including the Schedules, Annexes and
    Exhibits thereto, constitute the complete agreement between the
    signatories to this Agreement with respect to the subject matter
    hereof and supersedes all prior and contemporaneous
    negotiations, agreements and understandings with respect to the
    subject matter hereof. The provisions of the Transaction
    Documents shall be interpreted in a reasonable manner to effect
    the intent of the signatories to this Agreement.

 

    16.  Notices.  All notices,
    requests, demands, claims and other communications hereunder
    shall be in writing and shall be (a) transmitted by hand
    delivery, (b) mailed by first class, registered or
    certified mail, postage prepaid,

    

    10

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    (c) transmitted by overnight courier, or
    (d) transmitted by telecopy, and in each case, if to the
    Company, at the address set forth below:

 

    EPIX Pharmaceuticals, Inc.

    4 Maguire Road

    Lexington, MA 02421

    Attention: Chief Financial Officer

    Facsimile:
    (781) 761-7632

    Telephone:
    (781) 761-7600

 

    with a copy to:

 

    Goodwin Procter LLP

    Exchange Place

    53 State Street

    Boston, MA 02109

    Facsimile:
    (617) 523-1231

    Telephone:
    (617) 570-1000

    Attention: Edward A. King, Esq.

 

    if to a Noteholder, to the address set forth on the signature
    pages to this Agreement, with a copy to the Noteholders’
    counsel:

 

    Schulte Roth & Zabel LLP

    919 Third Avenue

    New York, New York 10022

    Facsimile:
    (212) 593-5955

    Telephone:
    (212) 756-2000

    Attention: Eleazer N. Klein, Esq.

 

    if to the Buyer Parties, to the address set forth below, with a
    copy to the Buyer Parties’ counsel:

 

    Lantheus Medical Imaging, Inc.

    331 Treble Cove Road

    North Billerica, MA  01862

    Attn:  Michael Duffy, Esq.

    Facsimile: (978) 671-8724

 

    Weil, Gotshal & Manges LLP

    767 Fifth Avenue

    New York, NY 10153

    Attn:  David Blittner, Esq.

    Facsimile: (212) 310-8007

 

    Notices mailed or transmitted in accordance with the foregoing
    shall be deemed to have been given upon receipt.

 

    17.  Governing Law.  This
    Agreement, the rights of the parties and all claims, actions,
    causes of action, suits, litigation, controversies, hearings,
    charges, complaints or proceedings arising in whole or in part
    under or in connection herewith, will be governed by and
    construed in accordance with the domestic substantive laws of
    the State of New York, without giving effect to any choice or
    conflict of law provision or rule that would cause the
    application of the laws of any other jurisdiction.

 

    18.  Jurisdiction; Waiver of Jury
    Trial.  By its execution and delivery of this
    Agreement, each of the signatories to this Agreement irrevocably
    and unconditionally agrees that any legal action, suit or
    proceeding against it with respect to any matter under or
    arising out of or in connection with this Agreement or for
    recognition or enforcement of any judgment rendered in any such
    action, suit or proceeding, shall be brought exclusively in a
    federal or state court of

    

    11

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    competent jurisdiction in the State of New York in the Borough
    of Manhattan. By its execution and delivery of this Agreement,
    each of the signatories to this Agreement irrevocably accepts
    and submits itself to the jurisdiction of a court of competent
    jurisdiction in the State of New York, as applicable under the
    preceding sentence, with respect to any such action, suit or
    proceeding. Each of the signatories to this Agreement waives any
    right it may have, and agrees not to request, trial by jury in
    any suit, action or proceeding with respect to this Agreement
    and the transactions contemplated hereby.

 

    19.  Consent to Service of
    Process.  Each of the signatories to this
    Agreement irrevocably consents to service of process by mail at
    the address listed with the signature of each such party on the
    signature pages to this Agreement. Each of the signatories to
    this Agreement agrees that its submission to jurisdiction and
    consent to service of process by mail is made for the express
    benefit of each of the other signatories to this Agreement.
    Nothing contained herein shall be deemed to limit in any way any
    right to serve process in any manner permitted by law.

 

    20.  Specific Performance.  It
    is understood and agreed by each of the signatories to this
    Agreement that money damages would not be a sufficient remedy
    for any breach of this Agreement by any party and each
    non-breaching party shall be entitled to specific performance,
    injunctive, recessionary or other equitable relief as remedy for
    any such breach, without the requirement to post any bond or
    security.

 

    21.  Headings.  The headings
    of the sections, paragraphs and subsections of this Agreement
    are inserted for convenience only and shall not affect the
    interpretation hereof.

 

    22.  Successors and
    Assigns.  This Agreement is intended to bind
    and inure to the benefit of the signatories to this Agreement
    and their respective successors, permitted assigns, heirs,
    executors, administrators and representatives. The agreements,
    representations and obligations of the undersigned parties under
    this Agreement are, in all respects, several and not joint.

 

    23.  Additional Notes.  If,
    after the date hereof and prior to expiration of the Exchange
    Offer, a Noteholder acquires (including in a transaction with
    another Noteholder permitted by Section 3(b) hereof)
    beneficial or record ownership of any additional Notes for
    itself or any account or fund managed by such Noteholder which
    is not restricted in its ability to tender any such additional
    Notes in accordance with the terms of this Agreement and the
    Exchange Offer (any such Notes, “Additional
    Notes”), such Noteholder shall promptly
    notify the Company of such acquisition and the provisions of
    this Agreement shall be applicable to such Additional Notes as
    if such Additional Notes had been Tender Notes owned by such
    Noteholder as of the date hereof. The provisions of the
    immediately preceding sentence shall be effective with respect
    to Additional Notes without action by any person or entity
    immediately upon the acquisition by such Noteholder of
    beneficial or record ownership of such Additional Notes.

 

    24.  Counterparts.  This
    Agreement may be executed in one or more counterparts, each of
    which shall be deemed an original and all of which shall
    constitute one and the same agreement. Delivery of an executed
    counterpart of a signature page by facsimile shall be as
    effective as delivery of a manually executed counterpart.

 

    25.  No Third-Party
    Beneficiaries.  Except as provided below, this
    Agreement shall be solely for the benefit of the signatories to
    this Agreement, and no other Person or entity shall be a
    third-party beneficiary hereof. Each of the Noteholders and the
    Company acknowledges and agrees that, notwithstanding anything
    to the contrary in this Agreement, the Buyer Parties have relied
    on the Buyer Party Provisions and are express third party
    beneficiaries thereof with the express right and ability to
    enforce the obligations of each of the Noteholders and the
    Company thereunder directly against each of the Noteholders and
    the Company to the full extent thereof; provided however, that
    the Buyer Parties shall constitute third party beneficiaries to
    Section 12 for purposes of the previous sentence solely
    in the event and to the extent that any amendments, changes or
    supplements to or waivers, modifications or terminations of the
    Buyer Party Provisions would adversely affect (i) Section
    10 in any way or (ii) any of the other Buyer Party
    Provisions in a way that adversely affects the Buyer
    Party’s ability to enforce Section 10. The Company shall
    not in any way hinder, compromise or delay the Buyer
    Parties’ right and ability to enforce the obligations of
    any of the Noteholders under the Buyer Party Provisions directly
    against such Noteholders to the extent set forth in the
    immediately preceding sentence (including, for the sake of
    clarity, the proviso thereto).

    

    12

 

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    26.  Severability.  If any
    provision of this Agreement is found by any court of competent
    jurisdiction to be invalid or unenforceable, the provision that
    would otherwise be prohibited, invalid or unenforceable shall be
    deemed amended to apply to the fullest extent that it would be
    valid and enforceable, and the invalidity or unenforceability of
    such provision shall not affect the validity of the remaining
    provisions of this Agreement so long as this Agreement as so
    modified continues to express, without material change, the
    original intentions of the parties as to the subject matter
    hereof and the prohibited nature, invalidity or unenforceability
    of the provision(s) in question does not substantially impair
    the respective expectations or reciprocal obligations of the
    parties or the practical realization of the benefits that would
    otherwise be conferred upon the parties. The parties will
    endeavor in good faith negotiations to replace the prohibited,
    invalid or unenforceable provision(s) with a valid provision(s),
    the effect of which comes as close as possible to that of the
    prohibited, invalid or unenforceable provision(s).

 

    27.  Consideration.  It is
    hereby acknowledged by each of the signatories to this Agreement
    that no consideration (other than the obligations of the other
    parties under this Agreement and the other Exchange Documents)
    has been paid or shall be due or paid to the parties for their
    agreement to support the Exchange Offer and Consent Solicitation
    in accordance with the terms and conditions of this Agreement.

 

    28.  Disclosure of Individual
    Holdings.  Unless required by applicable law,
    the Company shall not disclose the face amount of Tender Notes
    held by a Noteholder without the prior written consent of such
    Noteholder; provided, however, that if such disclosure is
    required by law, the Company shall afford such Noteholder a
    reasonable opportunity to review and comment upon any such
    disclosure prior to the release or publication thereof. The
    foregoing shall not prohibit the Company from disclosing the
    aggregate face amount of the Tender Notes held by the
    Noteholders as a group.

 

    29.  Independent Nature of Each
    Noteholder’s Obligations and Rights.  The
    obligations of each Noteholder hereunder are several and not
    joint with the obligations of any other Noteholder hereunder,
    and no Noteholder shall be responsible in any way for the
    performance of the obligations of any other Noteholder
    hereunder. Nothing contained herein or in any other agreement or
    document, and no action taken by any Noteholder pursuant hereto
    or thereto, shall be deemed to constitute the Noteholders as a
    group, a partnership, an association, a joint venture or any
    other kind of entity, or create a presumption that the
    Noteholders are in any way acting in concert or as a group with
    respect to such obligations or the transactions contemplated by
    this Agreement. Each Noteholder shall be entitled to protect and
    enforce its rights, including, without limitation, the rights
    arising out of this Agreement, and it shall not be necessary for
    any other Noteholder to be joined as an additional party in any
    proceeding for such purpose.

 

    30.  Fees and Expenses.  The
    Company shall pay all of its expenses incurred in connection
    with the preparation, execution and delivery of the Transaction
    Documents and related documents and the consummation of the
    transactions contemplated thereby.

 

    [SIGNATURES
    BEGIN ON NEXT PAGE]
    

    

    13

 

    IN WITNESS WHEREOF, the parties hereto have caused this
    Restructuring Support Agreement to be duly executed as of the
    date first set forth above.

 

 

    THE COMPANY:

 

    EPIX PHARMACEUTICALS, INC.

 

			
	 	    By: 
	
    /s/  Elkan
    Gamzu, Ph.D.

    Name:     Elkan Gamzu, Ph.D.

			
	 	    Title: 
	
    Chief Executive Officer

 

 

    NOTEHOLDERS:

 

	 	 	 
	

    Name of Holder:

	
 
	
    Loomis, Sayles & Company, L.P.,

    as investment manager for one or more

    discretionary accounts

    

    By: Loomis, Sayles & Company,

    Incorporated, its General Partner

	
 
	
 
	
 

	

    Signatory:

	
 
	
    /s/  
Thomas
    H. Day

    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    Thomas H. Day

    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	

    Title:

	
 
	
    Assistant General Counsel

    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    Address For Notice:

	
 
	
 
	
 

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
    Loomis, Sayles & Company, L.P.

    One Financial Center

    Boston, MA 02111

    Facsimile: (617) 951-2430

    Telephone: (617) 346-9786

    Attention: Deirdre A. Walsh

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

 

    [SIGNATURE PAGES TO RESTRUCTURING SUPPORT AGREEMENT]

    

    14

 

 

    NOTEHOLDERS
    (CONTINUED):
    

 

	 	 	 
	

    Name of Holder:

	
 
	
    Pioneer Funds — US High Yield (LUX)

    GE Singapore Life Insurance Fund 

    Pioneer High Yield Fund

    ING Pioneer High Yield Portfolio

    Pioneer High Yield VCT Portfolio

	
 
	
 
	
 

	
 
	
 
	

    By: Pioneer Investment Management, Inc., its Advisor

	
 
	
 
	
 

	

    Signatory:

	
 
	
    /s/ Kenneth J. Taubes

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    Kenneth J. Taubes

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	

    Title:

	
 
	
    Senior Vice President

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    Address For Notice:

	
 
	
 
	
 

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
    Pioneer Investment Management

    60 State Street

    Boston, MA 02109

    Facsimile: (617) 422-4276

    Telephone: (617) 422-4598

    Attention: David Brecht, CFA

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

 

    [SIGNATURE PAGES TO RESTRUCTURING SUPPORT AGREEMENT]

    

    15

 

 

    NOTEHOLDERS
    (CONTINUED):
    

 

	 	 	 
	

    Name of Holder:

	
 
	
    Highbridge International LLC

	
 
	
 
	
 

	
 
	
 
	

    By: Highbridge Capital Management, LLC,

    as Trading Advisor.

	
 
	
 
	
 

	

    Signatory:

	
 
	
    /s/ Mark Vanacore

    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    Mark Vanacore

    

	
 
	
 
	
 

	

    Title:

	
 
	
    Managing Director

    

	
 
	
 
	
 

	
 
	
 
	
    Address For Notice:

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
    Highbridge Capital Management

    9 West
    57th Street,

    27th Floor

    New York, New York  10019

    Facsimile: (212) 755-4250

    Telephone: (212) 287-4672

    Attention: Jonathan Dorfman

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

 

    [SIGNATURE PAGES TO RESTRUCTURING SUPPORT AGREEMENT]

    

    16

 

			
	 	
	
    NOTEHOLDERS (CONTINUED):

 

	 	 	 
	

    Name of Holder:

	
 
	
    Putnam Convertible Income-Growth Trust

	
 
	
 
	
    Putnam High Income Securities Fund

	
 
	
 
	
    Putnam Income Strategies Fund

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	

    By:  Putnam Investment Management, LLC

	
 
	
 
	
 

	

    Signatory:

	
 
	
    /s/ James F. Clark

    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    James F. Clark

    

	
 
	
 
	
 

	

    Title:

	
 
	
    Senior Vice President

    

	
 
	
 
	
 

	
 
	
 
	
    Address For Notice:

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
    Putnam Investments 

    One Post Office Square

    Boston, MA 02109

    Facsimile: (617) 760-1625Telephone:  (617) 760-1000

    Attention: General Counsel

 

    Each of the Putnam funds identified on this signature page shall
    be referred to herein as a “Fund”. Under this
    Agreement, each Fund is acting on its own behalf separately from
    any other Fund and neither jointly nor jointly and severally
    with any other Fund or any other person. A copy of the
    Declaration of Trust of each Fund is on file with the Secretary
    of State of the Commonwealth of Massachusetts and notice is
    given that this Agreement is executed on behalf of the trustees
    of each Fund as trustees and not individually and that the
    obligations of this Agreement are not binding on any of the
    trustees or officers or shareholders individually, but are
    binding only on the assets and property of each Fund with
    respect to its obligations hereunder.

    

    17

 

 

	 	 	 
	

    Name of Holder:

	
 
	

Franklin & Marshall College

LGT Capital Invest (SC3) Limited - U.S.
High Yield Convertible

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	

    By:  The Putnam Advisory Company, LLC

	
 
	
 
	
 

	

    Signatory:

	
 
	
    /s/ James F. Clark

    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    James F. Clark

    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	

    Title:

	
 
	
    Senior Vice President

    

	
 
	
 
	
 

	
 
	
 
	
    Address For Notice:

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
    Putnam Investments

    One Post Office Square

    Boston, MA 02109

    Facsimile: (617) 760,1625

    Telephone:  (617) 760-1000

    Attention: General Counsel

	
 
	
 
	
    

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
 

	
 
	
 
	
    

 

    [SIGNATURE PAGES TO RESTRUCTURING SUPPORT AGREEMENT]

    

    18

 

    Confidential —
    For Discussion and Settlement Purposes Only 

    Subject to Federal Rule of Evidence 408

 

    SCHEDULE A

 

    TO THE RESTRUCTURING SUPPORT AGREEMENT

 

    Noteholder and Face Amount of Notes to be Tendered

 

	 	 	 	 	 
	
 
	
 
	
    Face Amount of Notes to be

    
	
 

	

    Name

	
 
	
    Tendered
	
 

	 

	

    Loomis, Sayles & Company, Incorporated (as investment
    manager for one or more discretionary accounts)

	
 
	
    $
	
    25,667,000
	
 

	

    Pioneer Investment Management, Inc., (as advisor on behalf of
    entities listed on its signature page hereto)

	
 
	
    $
	
    33,000,000
	
 

	

    Highbridge International LLC

	
 
	
    $
	
    13,099,000
	
 

	

    Putnam Investment Management, LLC and The

	
 
	
 
	
 
	
 

	

    Putnam Advisory Company, LLC, (as investment manager on behalf
    of their respective client accounts)

	
 
	
    $
	
    10,778,000
	
 

	
 
	
 
	
 
	
 
	
 

	

    Total

	
 
	
    $
	
    82,544,000
	
 

 

 

    Schedule A
    

 

    EXHIBITS

    TO THE RESTRUCTURING SUPPORT AGREEMENT

 

    Exhibit A: Proposed Amendments

 

    Exhibit B: Purchase Agreement

 

    Exhibit C: Form of Registration Rights Agreement

 

    Exhibit D: Form of Contingent Value Rights Agreement

 

    Exhibit E: Form of Acknowledgement of Transfer

 

    Exhibit F: Form of Noteholder Questionnaire

 

    EXHIBIT E

    TO THE RESTRUCTURING SUPPORT AGREEMENT

 

    Form of Acknowledgement of Transfer

 

    EPIX Pharmaceuticals, Inc.

    4 Maguire Road

    Lexington, MA 02421

    Attn:
    [          ]

 

    Ladies and Gentlemen:

 

    Reference is made to that certain Restructuring Support
    Agreement, dated as of April 6, 2009 (the
    “Agreement”), by and among EPIX
    Pharmaceuticals, Inc. (the “Company”)
    and certain beneficial owners of (or investment managers or
    advisors for accounts that own) the 3.00% Convertible
    Senior Notes due June 15, 2024 (the
    “Notes”) of the Company.

 

    [Name of the transferor] intends to transfer
    [insert amount] in aggregate principal amount of
    Notes to the undersigned.

 

    The undersigned acknowledges and agrees that the foregoing
    [Notes] will be transferred to the undersigned
    subject to the terms and conditions of the Agreement and that
    the undersigned shall be bound by the terms and conditions of
    the Agreement as to the foregoing Notes as a Noteholder
    thereunder. In furtherance of the foregoing, as a condition to
    such transfer, by signing below the undersigned hereby affirms
    each of the representations, warranties, covenants and
    agreements of the Noteholders contained in the Agreement.

 

    Very truly yours,

 

    [Transferee]

 

			
	 	    By: 
	
        

			
	 	    Name: 
	

			
	 	    Title:

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00157-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00157-of-00352.parquet"}]]