Document:

EX-10.3

 Exhibit 10.3 

RELEASE AND SETTLEMENT AGREEMENT 

This Release and Settlement Agreement (“Agreement”) is entered into effective as of July 21, 2015 by and between
SCYNEXIS, Inc., a Delaware corporation (the “Company”), and Yves Ribeill (“Employee”). 
 WHEREAS,
Employee and the Company are parties to an Amended and Restated Employment Agreement executed January 15, 2008 by the Company and December 12, 2012 (the “Employment Agreement”) pursuant to which Employee has been employed by the
Company; 
 WHEREAS, Employee and the Company have agreed that Employee’s employment with the Company terminated on the Effective Date
and Employee and the Company now desire to fully and finally settle and resolve all matters arising, directly or indirectly, out of the Employment Agreement, Employee’s employment or the conclusion thereof according to the terms of this
Agreement; and 
 WHEREAS, the Bonus Letter describes benefits for Employee that Employee would not otherwise be entitled to under the
Employment Agreement or otherwise, and it is condition of the Bonus Letter that the consideration provided in the Bonus Letter is conditioned upon Employee entering into this Agreement, and as a partial inducement to the Company to grant such
consideration, Employee and the Company have agreed to enter into this Agreement. 
 NOW, THEREFORE, in consideration of the premises and
the mutual promises contained herein and the payment of the monies hereinafter recited, the receipt and adequacy of which are hereby acknowledged, the parties hereby agree as follows: 

1. Employee’s employment with the Company terminated as of the Effective Date. Employee hereby waives all rights to reemployment or
reinstatement from and after the Effective Date and Employee agrees that Employee will not reapply for employment with the Company. The Company will pay Employee all wages and accrued but unpaid vacation due Employee through the Effective Date on
the regularly scheduled payroll date of the Company following the Effective Date. The Company will also reimburse Employee for any reimbursable expenses incurred through the Effective Date that are submitted within 30 days of the Effective Date.
Except for such amounts, Employee agrees that Employee has been paid in full for all wages, bonuses, accrued vacation, commissions, severance, reimbursable expenses and any other amounts or benefits due to or promised to Employee by the Company,
other than those described in the Bonus Letter, which are contingent upon the execution, delivery and effectiveness of this Agreement. 
 2. (A) In
consideration of the execution of and compliance with all of the terms of this Agreement by Employee and specifically the release set forth in Section 2(B) below, the Company shall (i) pay Employee an amount equal to $100,000 (less all
applicable deductions) (the “Lump Sum Payment”) which payment will be made as set forth below, (ii) pay Employee an amount equal to $900,000 (less all applicable deductions) (the “Severance Payment”), which
payment will be made as set forth below, and (iii) will pay, on Employee’s behalf, directly to the insurance carrier (or to Company, as to self-insured plans) the current Company share of the costs of

 
coverage for continued health insurance coverage, at the same coverage level and on the same terms and conditions which applied immediately prior to the date of the Employee’s termination,
to continue Employee’s insurance coverage through January 31, 2016; provided that Employee first (1) executes this Agreement and does not revoke Employee’s release of the Preserved Claims (as defined in Section 3 and
(2) as to the benefits provided in subsection (iii) above, properly elects and maintains continued health insurance coverage through COBRA and provided further that such benefits continue to be offered under the Company sponsored plans.

 (B) In consideration of the good and valuable consideration provided to Employee as recited in Section 2(A) above, the receipt and
sufficiency of which are hereby acknowledged, Employee for Employee, Employee’s executors, heirs, administrators, assigns, and anyone claiming by, through, or under them, hereby irrevocably (except as specifically set forth below) and
unconditionally releases and forever discharges the Company and each of its past, present, and future officers, directors, employees, stockholders and representatives (the “Releasees”) from any and all claims, demands, lawsuits,
debts, defenses, actions or causes of action, obligations, damages, sums of money, loss of services, compensation, pain and suffering, attorneys’ fees, cost and expenses of suit, and liabilities whatsoever (“Employee Claims”),
which Employee had, now has or may have, whether the same be at law, in equity, or mixed, whether known or unknown, suspected or unsuspected, now existing or which may arise hereafter, arising out of or related to, any matter, cause, or event which
has happened, developed, or occurred before the execution of this Agreement, including without limitation, any and all suits in tort or contract, and any Employee Claims or suits relating to the breach of an oral or written contract,
misrepresentation, defamation, and interference with prospective economic advantage, interference with contract, intentional and negligent infliction of emotional distress, negligence, promissory estoppel, invasion of privacy, libel, slander, breach
of the covenant of good faith and fair dealing, any claims relating to or arising out of Employee’s right to purchase any shares of stock of the Company, including without limitation any claims for misrepresentation, fraud or securities fraud
under any state or federal law, and Employee Claims arising out of, based on, or connected with Employee’s employment by the Company and the termination of that employment including any causes of action or Employee Claims for unlawful
employment discrimination arising under or based on Title VII of the Civil Rights Act of 1964, as amended; the Employee Retirement Income Security Act of 1974, as amended; the Rehabilitation Act of 1973, as amended; the Americans with Disabilities
Act; the Occupational Safety and Health Act of 1970, as amended; the National Labor Relations Act of 1935, as amended; the Family and Medical Leave Act of 1993, as amended; the Age Discrimination in Employment Act, as amended; the Older Workers
Benefit Protection Act, as amended; Section 1981 of the Civil Rights Act of 1866; the Equal Pay Act of 1963; Section 1985 of the Civil Rights Act of 1871; and any other local, state or federal equal employment opportunity law, public
policy, order, or regulation affecting or relating to the claims or rights of employees, which Employee ever had, now has, or claims to have against the Company (including all officers, directors, partners, employees, stockholders, representatives
and affiliates thereof and all officers, directors, partners, employees, stockholders, representatives and affiliates of any subsidiary thereof), except as otherwise prohibited by law or such rights, benefits, and claims of Employee which expressly
accrue under and pursuant to this Agreement; provided that Employee and Company further agree that (i) Employee Claims pursuant to the Age Discrimination in Employment Act, as amended, which arise after the date of the execution of this
Agreement shall not be released and (ii) Employee expressly retains the right to file a charge or complaint or participate in an investigation 

 
or procedure with the Equal Employment Opportunity Commission, but waives any and all right to receipt of damages resulting from any charge or complaint brought by Employee, the Equal Employment
Opportunity Commission or anyone else. Employee further agrees not to institute any complaint, or lawsuit to challenge the validity of this Agreement or the circumstances surrounding its execution. It is expressly agreed and understood that the
release contained herein is a GENERAL RELEASE. Employee agrees that the amount specified in Section 2(A) above as the consideration for the release granted in this Section 2(B) is valid consideration to which Employee is not otherwise
entitled. 
 The Company will pay the Lump Sum Payment in a single installment on the first regularly scheduled pay date processed after the
eighth day after Employee delivers an executed copy of this Agreement to the Company and does not revoke it as set forth below. 
 The
Company will pay the Severance Payment in 24 installments of $37,500 in accordance with the regularly scheduled payroll of the Company, commencing on the first pay date processed after the eighth day after Employee delivers an executed copy of this
Agreement to the Company and does not revoke it as set forth below. 
 (C) The Company and Employee acknowledge and agree that the Company
has issued to the Employee options to purchase an aggregate of 267,881 shares of the common stock of the Company. All options that are not vested by their terms as of the Effective Date will be fully vested as of the Effective Date. In addition, the
exercise period for all vested options (excluding options from the 1999 Plan but including those that vest pursuant to this paragraph) shall extend through July 31, 2019. All other terms and conditions of such options shall be as set forth in
that the Incentive Stock Option Agreement(s) pursuant to which options were granted (the “Stock Option Agreement”). 
 3.
The Company hereby advises Employee to consult with an attorney prior to executing this Agreement. Employee is also advised that Employee has at least forty-five (45) days to consider the meaning and effect of this Agreement. If Employee elects
to sign this Agreement and return it to the Company before forty-five (45) days have elapsed from the date Employee has received this Agreement, Employee acknowledges that any such election is a knowing and voluntary waiver of the right to take
forty-five (45) days to consider this Agreement and that Employee has made this decision after receiving advice from legal counsel or after rejecting the Company’s recommendation that Employee obtain the advice of counsel. Employee further
understands that Employee may revoke the releases granted by Employee in Section 2(B) of this Agreement relating to the Age Discrimination in Employment Act and the Older Workers Benefit Protection Act, (the “Preserved
Claims”), for a period of seven (7) days following the date Employee executes this Agreement (the “Revocation Period”). This Agreement shall become effective and enforceable with respect to the Preserved Claims once
the Revocation Period has expired without exercise by Employee of Employee’s revocation rights described in this Section 3. If Employee shall exercise the revocation rights contemplated in this Section, Employee shall retain, and not
release, his/her respective rights with respect to the Preserved Claims. Any revocation within the Revocation Period must be submitted in writing to the Company and shall state, “I, Yves J. Ribeill, hereby revoke my acceptance of the release
by me of the Preserved Claims as described 

 
in our Agreement which I signed and dated on July 23, 2015.” Any such revocation shall be delivered personally to the Company or sent to the Company by fax at 919-544-8668 to the
attention of the Chief of Staff, and received within seven (7) days of execution of this Agreement. If Employee elects to accept this Agreement, Employee must execute and return it to the Company on or before July 27, 2015. Employee
acknowledges receiving this Agreement on July 21, 2015. This Agreement may not be executed by Employee prior to the Effective Date. Employee acknowledges that the waivers and releases contained herein are made knowingly, consciously, and
with full appreciation that Employee will be forever foreclosed from pursuing any of the rights so waived and released. 
 4. Employee
hereby represents and warrants to the Company that Employee is the sole and exclusive owner of the claims or causes of action being released by this Agreement, that Employee has not conveyed or assigned any interest in such claims or causes of
action to any person or entity, and that such claims and causes of action have been fully and effectively released for all purposes. Employee further represents and warrants that Employee has no claims, lawsuits or actions pending in his/her own
name or on behalf of any other person or entity against any of the Releasees and does not intend to bring any claims on behalf of Employee or any other person against any of the Releasees. Employee further represents and warrants that Employee has
no cause to believe any violation of any local, state or federal law has occurred with regard to Employee’s employment or separation. Employee further represents and warrants that Employee will not participate or provide assistance to any
person or entity who files a claim or intends to file a claim against the Company, unless ordered to do so by a court of competent jurisdiction or otherwise allowed by law. 

5. Employee acknowledges that Employee has read this Agreement and fully understands its meaning and intent, and has executed this Agreement
knowingly and voluntarily, as a free and voluntary act, without duress, coercion, or undue influence exerted by or on behalf of any person or entity. 

6. Neither the Company nor Employee shall be regarded as a prevailing party for any purpose, including, but not limited to, determining
responsibility for or entitlement to attorneys’ fees or costs under any statute or otherwise. The Company and Employee expressly waive, as to each other, any and all claims for attorneys’ fees or costs. 

7. This Agreement will not be used or construed by any person or entity as an admission of liability or finding or admission that any
party’s rights were in any way violated by any other party and this Agreement may not be offered or received in evidence in any action or proceeding as an admission or concession of liability or wrongdoing on the part of any party. 

8. Each of the Company and Employee will keep the terms of this Agreement strictly confidential and shall not disclose any information
concerning the terms of this Agreement or provide a copy of the same to anyone except the party’s spouse (if applicable), legal or tax advisor, unless otherwise required by a court of competent jurisdiction. The Company shall be permitted to
disclose information concerning this Agreement and provide a copy to persons under an obligation of confidentiality for business purposes it deems legitimate and further may be permitted to disclosure this Agreement pursuant to any obligation under
law, including the Securities Exchange Act of 1934, as amended. If required by law to produce a copy or to make such disclosure, Employee will give the Company reasonable advance notice prior to such production or disclosure. 

 9. Except as required by law, Employee will not do or say anything that a reasonable person would
expect at the time would have the effect of diminishing or constraining the goodwill and good reputation of the Company or the Releasees or the Company’s business, products or services. This obligation will include, but shall not be limited to
refraining from making negative statements about the Releasees or the Company’s methods of doing business, the effectiveness of its business policies, or the quality of any of its services or personnel. This is a continuing obligation that
shall survive this Agreement. 
 10. Except as required or permitted by law, Employee will keep strictly confidential and not use for
personal benefit or disclose to others any confidential or proprietary business or financial information or trade secrets of the Company, or other technical, business, or financial information, the use or disclosure of which may be contrary to the
Company’s interests. This obligation shall remain in effect as to any confidential business or financial information or trade secrets of the Company for so long as such confidential business or financial information or such trade secrets shall
remain confidential and protected information of the Company under applicable law. Without limiting the generality of the foregoing, Employee hereby acknowledges and agrees that Employee will continue to be bound by the terms of the
Confidentiality, Inventions and Non-Competition Agreement between Employee and the Company dated on July 11, 2000 (the “Proprietary Information Agreement”), which terms are in full force and effect and will survive
Employee’s termination of employment with the Company. 
 11. Employee will return all property of the Company to the Company wherever
located on or before August 1, 2015, unless extended at the Company’s discretion, including, without limitation, all reports, files, memoranda, records, computer hardware and software, laptop computer and accessories, credit cards,
telephone calling cards, card-key passes, identification badges, door, file, vehicle and other keys, computer access codes, disks and instructional manuals, calculators, cellular telephones, and other physical or personal property which have been
provided for Employee’s use in connection with his/her employment with the Company. Notwithstanding anything to the contrary, the Company’s obligation to provide Employee with the consideration specified in this Agreement shall be
contingent upon Employee returning all Company property on or before the above date. 
 12. This Agreement shall be binding upon and inure
to the benefit of each of the Company and Employee and their respective predecessors, successors, assigns, heirs, executors, and administrators. Employee shall not assign this Agreement or delegate Employee’s obligations hereunder without the
prior written consent of the Company. 
 13. The Company and Employee acknowledge that this Agreement is intended to be a binding contract
between them and shall not be modified except by writing signed by each of the Company and Employee. Employee acknowledges that Employee has not relied on any representation or statement by any of the Releasees or by any of the Releasees’
agents, representatives or attorneys regarding the subject matter, basis or effect of this Agreement. The Company and Employee acknowledge that this Agreement, the Proprietary Information Agreement 

 
and the Stock Option Agreement contain and comprise the entire agreement and understanding of the parties with respect to the subject matter hereof and thereof and supersede any and all prior
oral and written agreements and understandings, and that there are no agreements or understandings other than those contained herein and in the Proprietary Information Agreement and the Stock Option Agreement. 

14. Each of the parties acknowledges and recognizes that a violation of this Agreement and its covenants will cause irreparable damage to the
other party and that the other party will have no adequate remedy at law for such violation. Accordingly, each of the parties agrees that the other party will be entitled, as a matter of right, to an injunction from any court of competent
jurisdiction restraining any further violation of the Agreement or covenant. This right to injunctive relief will be cumulative and in addition to whatever remedies the parties may otherwise have at law. 

15. The parties agree that the Company’s past, present, and future officers, directors, agents, stockholders, debt holders, employees,
and representatives are each beneficiaries of this Agreement, and may rely on it directly for enforcement of the release set forth in Section 2(B) and the other benefits contained herein. 

16. If one or more of the provisions, or portions thereof, of this Agreement are determined to be illegal or unenforceable, the remainder of
this Agreement will not be affected by that determination and each remaining provision, or portion thereof, will continue to be valid and effective and will be enforceable to the fullest extent permitted by law. 

17. This Agreement is made and entered into in the State of North Carolina and shall be governed by and construed in accordance with the laws
of the State of North Carolina, except with regard to the conflict of laws rules of such State. 
 PLEASE READ
CAREFULLY. THIS AGREEMENT INCLUDES A RELEASE OF ALL KNOWN AND UNKNOWN CLAIMS. 
 [Signature page follows] 

 IN WITNESS WHEREOF, the parties hereto, intending to be legally bound hereby, have executed this
RELEASE AND SETTLEMENT AGREEMENT as of the date below to be effective as of the Effective Date. 
  

			
	EMPLOYEE:
		
	Signature:	 	 /s/ Yves J. Ribeill, Ph.D.

		 	Yves J. Ribeill, Ph.D.
		
	Date:	 	 July 23, 2015

	
	SCYNEXIS, INC.
		
	By:	 	 /s/ Amanda S. Mancuso

Amanda S. Mancuso

		
	Its:	 	 Chief of Staff

		
	Date:	 	 July 23, 2015EX-10.1

 Exhibit 10.1 

SECOND AMENDMENT TO LEASE 

THIS SECOND AMENDMENT TO LEASE (hereinafter referred to as the “Amendment”) is dated as of this 20th day of July, 2015 by and
between FOREST CITY 88 SIDNEY STREET, LLC, a Delaware limited liability company (“Landlord”) and AGIOS PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). Capitalized terms used herein and not otherwise defined
shall have the meaning ascribed to such term in the Lease. 
 W I T NE S S E T H 

WHEREAS, Landlord and Tenant entered into that certain Lease dated as of September 15, 2014 (the “Original Lease”), as amended
by that certain First Amendment to Lease (the “First Amendment”) dated as of November 21, 2014 (the Original Lease and First Amendment shall be referred to collectively as, the “Lease”) with respect to certain premises
located at 88 Sidney Street, Cambridge, Massachusetts (the “Premises”); and 
 WHEREAS, Landlord and Tenant desire to amend the
Lease to expand the definition of Premises to include the fifth floor of the Building (the “Fifth Floor Expansion Space”), provide for an additional improvement allowance, and for other purposes, as set forth in this Amendment. 

NOW, THEREFORE, in consideration of the promises and mutual covenants hereinafter contained and other valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
  

	1.	Premises. Effective as of the date hereof, the term “Premises” set forth on Exhibit A of the Lease is deleted in its entirety and replaced with the following: 

“Premises: The Premises shall be comprised of approximately 146,034 rentable square feet as follows: 

 

					
	Floor 1 Suite 100A:	  	 	418 rsf	  
	Floor 1 Suite 100B:	  	 	340 rsf	  
	Floor 1 Suite 100:	  	 	7,086 rsf	  
	Floor 1 Suite 150:	  	 	4,928 rsf	  
	Floor 2 Suite 200:	  	 	33,452 rsf	  
	Floor 3 Suite 300:	  	 	33,464 rsf	  
	Floor 4 Suite 400:	  	 	33,530 rsf	  
	Floor 5 Suite 500:	  	 	32,816 rsf	  

 All as more particularly shown on the floor plans attached to this Lease as Exhibit B.” 

 

	2.	Annual Fixed Rent. Effective as of the date hereof, the term “Annual Fixed Rent for the Term” set forth on Exhibit A of the Lease shall be deleted in its entirety and replaced with the following:

 “Annual Fixed Rent: With respect to Suite 100A, Suite 100, Suite 300 and Suite 400: $57.25 per rsf, as adjusted per the
terms of Section 3.1 hereof. With respect to Suite 100B, Suite 150 and Suite 200: $60.00 per rsf, as adjusted per the terms of Section 3.1 hereof. With respect to Suite 500: $65.00 per rsf, as adjusted per the terms of Section 3.1
hereof.” 

  
 - 1 - 

	3.	Additional Rent. Tenant shall not be obligated to pay Additional Rent with respect to the Fifth Floor Expansion Space prior to the Rent Commencement Date for the Fifth Floor Expansion Space. 

 

	4.	Annual Increases to Annual Fixed Rent. Effective as of the date hereof, Section 3.1 shall be amended by deleting the second paragraph thereof and replacing it with the following: 

“On the first anniversary of the Rent Commencement Date, and on each anniversary thereafter, Annual Fixed Rent for Suites 100A, 100, 300
and 400 shall increase to an amount equal to one hundred two percent (102%) of the Annual Fixed Rent immediately preceding such anniversary. On the first anniversary of the Rent Commencement Date, and on each anniversary thereafter, Annual
Fixed Rent for Suites 100B, 150 and 200 shall increase to an amount equal to one hundred three percent (103%) of the Annual Fixed Rent immediately preceding such anniversary. On the first anniversary of the Rent Commencement Date for Fifth
Floor Expansion Space, and on each anniversary thereafter, Annual Fixed Rent for Suite 500 shall increase to an amount equal to one hundred three percent (103%) of the Annual Fixed Rent immediately preceding such anniversary.” 

 

	5.	Operating Expenses. Section 3.3 of the Lease is hereby amended by adding the following thereto: 

“Annual Estimates. Landlord shall deliver to Tenant a written estimate of Operating Expenses for each calendar year during the
Term (the “Annual Estimate”), which may be revised by Landlord no more than twice during such calendar year to reflect actual known or reasonably anticipated increases in Operating Expenses for that calendar year. Landlord
shall use reasonable efforts to deliver the Annual Estimate to Tenant by 60 days prior to the end of each calendar year, and shall take into account any comments by Tenant which are consistent with the rights and obligations of the parties under
this Lease. Landlord shall use good faith efforts to meet with Tenant from time to time prior to November 1st of each calendar year during the Term upon Tenant’s request to discuss
the Annual Estimate for the upcoming calendar year and Landlord’s budget for Operating Expenses for the Property for such year . The Annual Estimate shall include reasonably detailed line-item costs.” 

 

	6.	Tax Protest. Section 3.2 of the Lease is hereby amended by adding the following thereto: 

“Upon Tenant’s reasonable request, the Landlord shall use reasonable efforts to contest or seek abatement of any Real Estate Taxes
affecting the Premises. Should the Landlord contest or seek abatement of such taxes, then it shall do so with diligence and shall keep the Tenant appropriately informed, in the Landlord’s reasonable discretion, as to such action. Upon
Tenant’s request, Landlord shall provide Tenant with a copy of any notice of the assessed valuation of the Property and/or the Building received by Landlord, as well as copies of all tax bills and tax notices received by Landlord, and copies of
all papers filed by Landlord in connection with any such Tax Protest or Tax Proceeding. Tenant’s rights under this Section may be exercised only in respect of Tax Years occurring subsequent to the Commencement Date.” 

  
 - 2 - 

	7.	Tenant Personnel. Tenant shall have the right to station its own security or other personnel in the lobby of the Building and upon reasonable advance notice to utilize its own contractors or personnel for
cleaning, maintenance and other similar services in the Building, excluding, however, HVAC or other systems which may be shown as Landlord’s responsibility on the Tenant/Landlord Responsibility Matrix attached as Exhibit H-1. In the event
Tenant utilizes its own personnel or contractors for any such security, cleaning, maintenance or other similar services, Tenant shall pay all costs directly and the same shall not be included in Landlord’s costs for purposes calculating
Operating Expenses for the Property. 

  

	8.	Condition of Fifth Floor Expansion Space/Landlord’s Work. Landlord shall be responsible, at its sole cost and expense, to deliver the base building mechanical systems (HVAC, electrical, life safety and
plumbing), including, without limitation, the hot water heater, and the Shared Laboratory Systems (as defined in Section 2.3(c) of the Lease) that service the Fifth Floor Expansion Space in good operating condition and repair, and shall
maintain the same in accordance with Section 5.1 of the Lease. Except as provided in this Section 7, the parties hereby acknowledge and agree that all work performed by Tenant or required to be performed by Tenant under the Lease has been
performed to the satisfaction of Landlord. Landlord shall remain responsible, at its sole cost and expense, for all work to be performed by Landlord under the Lease (except as otherwise provided in this Second Amendment), including, without
limitation, final completion of all of Landlord’s Work pursuant to Section 2.1(c) of the Lease. 

  

	9.	Lease Commencement Date for Fifth Floor Expansion Space. The Lease Commencement Date for Fifth Floor Expansion Space shall be the date of this Amendment. 

 

	10.	Rent Commencement Date for Fifth Floor Expansion Space. The following shall be added as a definition on Exhibit A after the definition of Rent Commencement Date: 

 

			
	“Rent Commencement Date		
	for Fifth Floor Expansion		
	Space:		November 1, 2015.”

  

	11.	Tenant/Landlord Responsibility Matrix for the Building. Exhibit H-1 attached hereto shall be attached to the Lease as a new Exhibit H-1 and shall be referred to as the Tenant/Landlord Responsibility Matrix for
the Building. 

  

	12.	Leasehold Improvement Allowance. The defined term “Leasehold Improvements Allowance” set forth on Exhibit A shall be amended by deleting “$16,189,047.00” and replacing it with
“$20,126,967.00”. Additionally, the third sentence of Section 3 of Exhibit E to the Lease is hereby deleted in its entirety and replaced with the following: 

“The Tenant must apply to Landlord for reimbursement from the Leasehold Improvements Allowance applicable to the Fifth Floor Expansion
Space in the amount of Three Million Nine Hundred Thirty-Seven Thousand Nine Hundred Twenty and 00/100 Dollars ($3,937,920.00) (the “Fifth Floor Leasehold Improvement Allowance”) within twenty-four (24) months after the Rent
Commencement Date for the Fifth Floor Expansion Space. Tenant may use a portion of the Fifth Floor Improvement Allowance towards improvements on any floor in the Building, but only after Tenant has improved the Fifth Floor Expansion Space as
approved by Landlord.” 

  
 - 3 - 

	13.	Parking Privileges. The first sentence of the term “Parking Privileges” set forth on Exhibit A shall be deleted in its entirety and replaced with the following: 

“During the Term, Tenant shall be entitled to use and shall pay for two hundred eighteen (218) parking passes in accordance with
Section 2.4 of the Lease; provided, however, that from the Rent Commencement Date until the Rent Commencement Date for Fifth Floor Expansion Space, Tenant shall have the option to use and pay for a minimum of one hundred fifty-two
(152) parking passes, and from the Rent Commencement Date for Fifth Floor Expansion Space until the first anniversary of the Rent Commencement Date, Tenant shall have the option to use and pay for a minimum of two hundred one (201) parking
passes. Commencing with the first anniversary of the Rent Commencement Date, Tenant shall be obligated to pay for two hundred eighteen (218) parking passes.” 
  

	14.	Security Deposit. The defined term “Security Deposit” set forth on Exhibit A shall be amended by deleting “$2,189,270.17” and replacing it with “$2,900,283.50”. Upon execution of
this Amendment, Tenant shall deposit Seven Hundred Eleven Thousand Thirteen and 33/100 Dollars ($711,013.33) with the Landlord as an additional Security Deposit, so that the total amount of the Security Deposit set forth on Exhibit A shall be Two
Million Nine Hundred Thousand Two Hundred eighty three and 50/100 Dollars ($2,900,283.50). At Tenant’s election, such increase in the Security Deposit shall be effectuated by a substitution of a single new Letter of Credit. 

 

	15.	Floor Plans Showing Premises. Exhibit B to the Lease shall be deleted and replaced with a new Exhibit B attached hereto. 

  

	16.	Landlord Entity. The parties acknowledge that the Original Lease and the First Amendment both stated the name of the Landlord entity incorrectly. The correct name of the Landlord entity is “Forest City 88
Sidney Street, LLC”. 

  

	17.	Counterparts. This Amendment may be executed in any number of counterparts, each of which shall be deemed an original and all of which together shall constitute one and the same instrument. 

 

	18.	Brokers. Landlord and Tenant represent and warrant that they have had no dealings with any broker or agent in connection with this Amendment other than Colliers International New England, LLC and CBRE/New England
and each party shall indemnify and hold harmless the other party from claims for any brokerage commission. Landlord shall pay Colliers International New England, LLC and CBRE/New England a brokerage commission pursuant to the terms of a separate
agreement. 

  

	19.	Ratification. The Lease, as amended hereby, is in full force and effect, and is ratified and confirmed, and there are no other amendments or modifications thereto. 

 

	20.	Governing Law. This Amendment will be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts. 

  
 - 4 - 

	21.	Consents. This Amendment shall be subject to the prior written consent of the Ground Lessor, The Massachusetts Institute of Technology, and Landlord will use good faith best efforts to obtain such consent.

  

	22.	Due Authority. Each of Landlord and Tenant, for itself, warrants and represents that this Amendment is its duly adopted, approved and authorized act and that the person signing this Amendment has full authority
to bind, and to execute this Amendment on behalf of, the party he or she represents. 

  
 - 5 - 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment under seal, as of the day, month and year
first above written. 
  

									
	LANDLORD:
	
	 Forest City 88 Sidney Street, LLC,

a Delaware limited liability company

		
	By:		FC HCN 88 Holding, LLC,
			a Delaware limited liability company,
			Its sole member
			
			By:		FC HCN University Park, LLC,
					a Delaware limited liability company,
					Its sole member
				
					By:		Forest City University Park, LLC,
							a Delaware limited liability company
							Its managing member
					
							By:		/s/ Michael Farley
							Name:		Michael Farley
							Its:		Vice President

  

			
	TENANT:
	
	 AGIOS PHARMACEUTICALS, INC.,
 a
Delaware corporation

		
	By:		/s/ Glenn Goddard
	Name:		Glenn Goddard
	Title:		SVP, Finance

  
 - 6 - 

 EXHIBIT B 

Floor Plans Showing the Premises 

SEE ATTACHED 

  
 - 7 - 

 

 

  
 - 8 - 

 

 

  
 - 9 - 

 

 

  
 - 10 - 

 

 

  
 - 11 - 

 

 

  
 - 12 - 

 Exhibit H-1 

Tenant / Landlord Responsibility Matrix for the Fifth Floor Expansion Space 

Agios 
 88 Sidney Street 

Cambridge, MA 
 Tenant / Landlord Responsibility Matrix

 June 11, 2015 
  

					
	 Description
	  	 Landlord
	  	 Tenant

	SITEWORK	  		  	
	Domestic sanitary sewer connection to street	  	X	  	
	Lab waste sewer connection to individual tenant pH neutralization system	  	X	  	
	Roof storm drainage	  	X	  	
	Nstar primary and secondary electrical service	  	X	  	
	Nstar gas service	  	X	  	
	Domestic water service to Building	  	X	  	
	Fire protection water service to Building	  	X	  	
	STRUCTURE	  		  	
	Structural enhancements for specific Tenant load requirements	  		  	X
	Structural framing dunnage above roof for Base Building equipment	  	X	  	
	Structural framing dunnage above roof for Tenant equipment (subject to Landlord review and approval).	  		  	X
	Framed openings for Base Building utility risers	  	X	  	
	Framed openings for Tenant utility risers in addition	  		  	X
	Miscellaneous metals items and/or concrete pads for Base Building equipment	  	X	  	
	Miscellaneous metals items and/or concrete pads for Tenant equipment	  		  	X
	ROOFING	  		  	
	Single ply EPDM roofing system with rigid insulation	  	X	  	
	Roofing penetrations for Base Building equipment/systems	  	X	  	
	Roofing penetrations for Tenant equipment/systems by LL’s roofer to LL Spec	  		  	X
	Walkway pads to Base Building equipment	  	X	  	
	Walkway pads to Tenant equipment	  		  	X
	Roofing alterations due to Tenant changes	  		  	X
	EXTERIOR	  		  	
	Building exterior consisting of precast concrete and windows	  	X	  	
	Main Building entrances	  	X	  	
	Loading dock with loading dock elevator and stairwell	  		  	X
	Acoustic screening of Base Building rooftop equipment	  	X	  	
	Acoustic screening of Tenant rooftop equipment (space available within base building screening	  		  	X

  
 - 13 - 

					
	ELEVATORS	  		  	
	Three (2) passenger elevators, one (1) service with a capacity of 4,000 lbs.	  	X	  	
	WINDOW TREATMENT	  		  	
	Furnish and install Building standard blinds for all windows	  		  	X
	TENANT AREAS	  		  	
	Finishes at inside face of exterior walls	  		  	X
	Finishes at inside face at Tenant side of core partitions	  		  	X
	Toilet rooms within Tenant Premises in addition to those provided by base building	  		  	X
	Electrical closets within Tenant Premises	  		  	X
	Tel/data rooms for interconnection with Tenant tel/data	  		  	X
	Tenant kitchen areas	  		  	X
	Modifications to core areas to accommodate Tenant requirements	  		  	X
	Partitions, ceilings, flooring, painting, finishes, doors, frames, hardware, millwork, casework, equipment, and build out.	  		  	X
	Fixed or movable casework.	  		  	X
	Laboratory Equipment including but not limited to biosafety cabinets, autoclaves, glass washers.	  		  	X
	Chemical Fume Hoods, bench fume hood	  		  	X
	Shaft enclosures for Base Building systems’ risers	  	X	  	
	Shaft enclosures for Tenant risers (in addition to risers put in place for tenant use)	  		  	X
	FIRE PROTECTION	  		  	
	Fire service entrance including fire department connection, alarm valve, and flow protection	  	X	  	
	Core area distribution piping and sprinkler heads	  	X	  	
	Stair distribution piping and sprinkler heads	  	X	  	
	All run outs, drop heads, and related equipment within Tenant premises	  		  	X
	Modification of sprinkler piping and head locations to suit Tenant layout and hazard index	  		  	X
	Specialized extinguishing systems or containment for tenant program areas	  		  	X
	Preaction dry-pipe systems	  		  	X
	Fire extinguisher cabinets at core common areas	  	X	  	
	Fire extinguisher cabinets in Tenant Premises	  		  	X
	PLUMBING	  		  	
	Domestic water service with backflow prevention and Base Building risers	  	X	  	
	Domestic water distribution within Tenant Premises	  		  	X
	Tenant restroom plumbing fixtures compliant with accessibility requirements (in addition to those provided by the Base Building)	  		  	X
	Wall hydrants in common core areas (where required by code)	  	X	  	
	Tenant metering and sub-metering at Tenant connection	  		  	X
	Storm drainage system	  	X	  	
	Sanitary waste and vent service	  	X	  	
	Two stage active pH neutralization system (individual tenant system)	  		  	X
	Lab waste and vent pipe distribution	  		  	X

  
 - 14 - 

					
	Hot water generation for core restrooms	  	X	  	
	Non-potable Hot water generation for Tenant use	  		  	X
	Central lab air compressor and piping risers	  	X	  	
	Compressed air pipe distribution in Tenant Premises for specific points of use	  		  	X
	Central lab vacuum system and pipe risers	  		  	X
	Lab vacuum pipe distribution in Tenant Premises for specific points of use	  		  	X
	Tepid water generator and pipe risers	  		  	X
	Tepid water pipe distribution in Tenant Premises	  		  	X
	RO/DI water generator and pipe risers	  		  	X
	RO/DI water pipe distribution in Tenant Premises for specific points of use	  		  	X
	Manifolds, piping, and other requirements including cylinders, not specifically mentioned above	  		  	X
	NATURAL GAS	  		  	
	Natural gas service to Building and piping to Base Building boilers and Base Building generator	  	X	  	
	Natural gas service, pressure regulator and meter for Tenant equipment	  		  	X
	Natural gas piping from Tenant meter to Tenant Premises or Tenant equipment area.	  		  	X
	Natural gas pipe distribution within Tenant Premises	  		  	X
	Natural gas pressure regulator vent pipe riser from valve location through roof	  		  	X
	HEATING, VENTILATION, AIR CONDITIONING	  		  	
			
	Once-through supply air handling units with 30% prefilters, 85% final filters, with corresponding heating and cooling. Units are sized for approximately 1.5 cfm per square foot of lab space. 65%/35% lab/office ratio.	  	X	  	
	Boiler capacity for hot water reheats at lab/office space	  	X	  	
	Hot water reheat distribution to reheat coils	  		  	X
	Vertical supply air duct distribution	  		  	X
	Tenant Space Supply air duct distribution, VAV terminals, equipment connections, insulation, air terminals, dampers, hangers,	  		  	X
	Roof mounted laboratory exhaust fans	  		  	X
	Vertical exhaust air duct risers for general lab exhaust	  		  	X
	Roof mounted laboratory exhaust fans for specialty exhaust systems.	  		  	X
	Exhaust air duct distribution, exhaust air valves, equipment connections, insulation, air terminals, dampers, hangers, etc. within Tenant Premises.	  		  	X
	Exhaust air duct distribution, exhaust air valves, equipment connections, insulation, air terminals, dampers, hangers, etc.	  		  	X
	General Exhaust for Tenant Spaces from Risers	  		  	X
	Restroom exhaust for core area restrooms	  	X	  	
	Restroom exhaust for restrooms within Tenant Premises	  		  	X
	Electric room ventilation system for electrical closets within Tenant premises	  		  	X
	Sound attenuation for Tenant equipment to comply with Cambridge Noise Ordinance	  		  	X
	Additional/ dedicated cooling for Tenant requirements.	  		  	X

  
 - 15 - 

					
	ELECTRICAL	  		  	
	Electrical utility service to switchgear in main electrical vault	  	X	  	
	Provide the tenant with a proportionate share of the available power based on a sqft allocation	  	X	  	
	Standby power distribution within Tenant Premises 100% of existing service	  		  	X
	Lighting and power distribution for core areas	  	X	  	
	Lighting and power distribution for Tenant Premises	  		  	X
	Tenant Check Meter (s) for Tenant Connected Loads	  		  	X
	Common area life safety emergency lighting/signage	  	X	  	
	Tenant Premises life safety emergency lighting/signage	  		  	X
	Tenant panels, transformers, etc. in addition to Base Building	  		  	X
	Tenant UPS system, battery backup, and associated equipment/distribution	  		  	X
	FIRE ALARM	  		  	
	Base Building fire alarm system with devices in core areas	  	X	  	
	Fire alarm sub panels and devices for Tenant Premises with integration into Base Building system	  		  	X
	Alteration to fire alarm system to facilitate Tenant program	  		  	X
	TELEPHONE/DATA	  		  	
	Tel Data Riser Conduit from demark to each floor	  		  	X
	Tenant tel/data rooms	  		  	X
	Pathways from demarcation room directly into Tenant tel/data rooms	  		  	X
	Tel/Data cabling from demarcation room Tenant tel/data room.	  		  	X
	Fiber optic service for Tenant use	  		  	X
	Tel/data infrastructure including but not limited to servers, computers, phone systems, switches, routers, MUX panels, equipment racks, ladder racks, etc.	  		  	X
	Provisioning of circuits and service from service providers	  		  	X
	Audio visual systems and support	  		  	X
	Station cabling from Tenant tel/data room to all Tenant locations, within the suite and exterior to the suite, if needed	  		  	X
	SECURITY	  		  	
	Card access at Building entries	  		  	X
	Card access into or within Tenant Premises on separate Tenant installed and managed system	  		  	X

  
 - 16 -

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00247-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00247-of-00352.parquet"}]]