Document:

EX-10.20

 Exhibit 10.20 

***Text Omitted and Filed Separately 

with the Securities and Exchange Commission 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 

and 230.406 
 EXCLUSIVE
LICENSE AGREEMENT 
 Re: BCM BLG # 13-040 Entitled “Methods for Inducing Selective Apoptosis” 

This Exclusive License Agreement (hereinafter called “Agreement”), to be effective as of the 1st day of November, 2014 (hereinafter
called “Agreement Date”), is by and between Baylor College of Medicine (hereinafter called “BCM”), a Texas nonprofit corporation having its principal place of business at One Baylor Plaza, Houston, Texas 77030, and Bellicum
Pharmaceuticals, Inc., a corporation organized under the laws of Delaware and having a principal place of business at 2130 West Holcombe Blvd., Suite 850, Houston, TX 77030, and its Affiliates (hereinafter, collectively referred to as
“LICENSEE”). 
 WITNESSETH: 

WHEREAS, BCM’s mission is to advance human health through the integration of education, research, patient care and community service; and

 WHEREAS, BCM is the owner of Patent Rights as defined below; and 

WHEREAS, BCM is willing to grant a royalty bearing, worldwide, exclusive license to Patent Rights to LICENSEE on the terms set forth herein;
and 
 WHEREAS, LICENSEE desires to obtain said exclusive license under Patent Rights. 

NOW, THEREFORE, for and in consideration of the promises and other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the Parties hereto expressly agree as follows: 
  

	1.	DEFINITIONS AS USED HEREIN 

 1.1 The term “Affiliate” shall mean any
corporation, firm, limited liability company, partnership or other entity that directly controls or is controlled by or is under common control with LICENSEE. For purposes of this Section 1.1, “control” means the possession, directly
or indirectly, of the power to direct or cause the direction of the activities, management or policies of such entity, whether through the ownership of securities, by contract or otherwise. Without limitation, “control” shall be presumed
to exist when an entity (i) owns or directly controls fifty percent (50%) or more of the outstanding voting stock or other ownership interest of the other entity; or (ii) possesses directly or indirectly the power to elect or appoint
fifty percent (50%) or more of the members of the governing body of the other entity. 
 1.2 The term “BCM Confidential
Information” shall mean any proprietary and secret ideas, proprietary technical information, know-how and proprietary commercial information or other similar proprietary information that are owned by BCM. 

1.3 The term “Developers” shall mean [*...***...], employees of
BCM. 
 1.3 The term “Field” shall mean all fields. 

1.4 The term “Legal Costs” shall mean all legal fees and expenses, filing or maintenance fees, assessments and all other costs and
expenses reasonably incurred by BCM for prosecuting, obtaining and maintaining patent protection on the Patent Rights in the United States and foreign countries. 

  
  

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 1.5 The term “Licensed Product(s)” shall mean any product, process or service the
manufacture, use, sale, offer for sale or import of which, absent the rights and licenses granted by BCM to LICENSEE hereunder, would infringe a Valid Claim. 

1.6 The term “Net Sales” shall mean the gross amount of monies or cash equivalent or other consideration which is received for
sales, leases or other modes of transfer (excluding consideration received for the grant of a sublicense hereunder) of Licensed Products by LICENSEE or its sublicensee(s) to third parties (whether end users, wholesaler(s) or distributor(s)), less:

 (i) [*...***...]; 

(ii) [...***...]; 
 (iii) [...***...]; and 

(iv) [...***...]. 
 The term “Net Sales” in the
case of non-cash sales, shall mean the fair market value of the non-monetary consideration received by LICENSEE or sublicensees that is attributable to the sale, lease or other mode of transfer of Licensed Products to third parties. A sale of a
Licensed Product between LICENSEE and a sublicensee for resale to a third party shall not be considered a “sale” for the purpose of this Section 1.6, but the resale of such Licensed Product by such sublicensee or LICENSEE (as
applicable) to a third party shall be a “sale” under this Section 1.6. 
 1.7 The term “Party” shall mean either
LICENSEE or BCM, and “Parties” shall mean LICENSEE and BCM. 
 1.8 The term “Patent Rights” shall mean United States
Patent Application Serial No. 61/347,154, entitled “Methods for Inducing Selective Apoptosis” filed May 21, 2010, and (i) all patent applications (including provisional applications) that claim priority from Serial
No. 61/347,154, (ii) any and all divisions, reissues, re-examinations, renewals, continuations, continuations-in-part to the extent the claims are directed to subject matter specifically described in the aforementioned patent applications
and are dominated by the claims of the existing Patent Rights, and extensions thereof, (iii) any and all United States patents which issue from the foregoing described patent applications, and all other counterparts, pending or issued, and
patents in all other countries. Patent Rights shall specifically include the patents and/or patent applications identified in Appendix A. 

1.9 The term “Sublicensing Revenue” shall mean all cash and non-cash consideration, including, but not limited to, sublicensing
fees, milestone payments and sublicense maintenance fees, actually received by LICENSEE that is directly attributable to the grant of a sublicense under the license rights granted to LICENSEE hereunder; provided that in the event that LICENSEE
receives non-cash consideration, Sublicensing Revenue shall be calculated based on the fair market value of such non-cash consideration, assuming an arm’s length transaction made in the ordinary course of business, but expressly excluding the
following payments: 

  
  

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 (a) [...***...]; 

(b) [...***...]; 
 (c) [...***...]; 

(d) [...***...]; and 
 (e) [...***...]. 

1.10 The term “Territory” shall mean the entire world. 

1.11 The term “Valid Claim” shall mean a claim of a pending or an issued patent within the Patent Rights, which claim has not
expired, lapsed, been cancelled or become abandoned irrevocably and has not been declared invalid or unenforceable by an un-reversed and un-appealable decision or judgment of a court or other appropriate body of competent jurisdiction, and which has
not been admitted to be invalid or unenforceable through reissue, disclaimer or otherwise. 
  

	2.	GRANT OF LICENSE 

 2.1 License Grant. Subject to the restrictions set forth in
Sections 2.2 and 2.3, BCM hereby grants to LICENSEE an exclusive, worldwide, sublicensable license under the Patent Rights, to make, have made, use, market, sell, offer to sell, lease and import Licensed Products in the Field in the Territory. 

2.2 Restrictions on License. The grant in Section 2.1 shall be further subject to, restricted by and non-exclusive with respect
to: 
 (i) the making or use of the Subject Technology and Patent Rights by BCM for non-commercial research, patient care, teaching and other educationally
related purposes; 
 (ii) the making or use of the Subject Technology and Patent Rights by the Developers for non-commercial research purposes at academic
or research institutions; 
 (iii) any non-exclusive license of the Subject Technology and/or Patent Rights that BCM grants to other academic or research
institutions for non-commercial research purposes; 
 (iv) the making or use of the Subject Technology and Patent Rights by academic and research
institutions for non-commercial research purposes; and 

  
  

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 (v) any non-exclusive license of the Subject Technology and/or Patent Rights that BCM is required by law or
regulation to grant to the United States of America or to a foreign state pursuant to an existing or future treaty with the United States of America. 

(vi) any non-exclusive license of the Subject Technology and/or Patent Rights that BCM grants to
[*...***...] under [...***...] existing material transfer agreements with BCM. 

2.3 Government Reservation. Rights and licenses granted to LICENSEE under this Agreement are subject to rights required to be granted
to the Government of the United States of America pursuant to 35 USC Section 200-212, including a nonexclusive, nontransferable, irrevocable, paid-up license to practice or have practiced for or on behalf of the United States the subject
inventions throughout the world. 
  

	3.	DILIGENCE 

 LICENSEE shall itself use, or shall cause its sublicensees to use,
commercially reasonable efforts, consistent with sound and reasonable business practices and judgment, to diligently proceed to introduce at least one Licensed Product into the commercial market. Demonstration of such commercially reasonable efforts
shall include, but not be limited to: 
  

	 	(i)	Annual report provided to BCM describing LICENSEE’s or its sublicensees’ progress and activities related to research and development, securing regulatory approvals, manufacturing, sublicensing, marketing, and
sales of Licensed Products; 

  

	 	(ii)	Initiation of a first Phase II clinical trial of a first Licensed Product within [...***...] of the Agreement Date; 

  

	 	(iii)	Initiation of a first pivotal clinical trial and/or Phase III clinical trial of a first Licensed Product within [...***...] of the Agreement Date; and 

 

	 	(iv)	The production of the commercialized Licensed Products and the marketing and support of the commercialized Licensed Products with at least a substantially similar level of effort as LICENSEE employs for comparable
products and services marketed by LICENSEE. 

 Timely achievement of the foregoing items (i-iv) shall be deemed to satisfy and fully discharge
LICENSEE’s obligations under this Section 3. BCM recognizes that there are many uncertainties associated with the development and commercialization of therapeutic products and the regulatory process required by the FDA (and foreign
regulatory authorities that are equivalent to the FDA). Accordingly, in the event that LICENSEE can demonstrate to BCM its commercially reasonable efforts (with reasonable supporting documentation) to fulfill items (ii) and (iii) above,
LICENSEE and BCM will negotiate in good faith a reasonable revision to items (ii) and (iii) above; provided that BCM shall not unreasonably withhold such revision. If LICENSEE anticipates that it will not fulfill a revised item
(ii) or (iii), LICENSEE may obtain a [...***...] extension of time in which to achieve these milestones, by paying to BCM a one-time, [...***...] dollars ($[...***...] US) extension fee. 

 

	4.	PAYMENTS 

 4.1 License Execution Fee. As partial consideration for the license
rights conveyed by BCM under this Agreement, LICENSEE shall pay BCM a non-refundable license fee of TWENTY FIVE 

  
  

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 THOUSAND DOLLARS ($25,000.00 USD). Such payment shall be due within five (5) business days after complete
execution of this Agreement, and shall be paid and delivered to BCM in accordance with the invoice instructions provided below. 
 4.2
Annual Maintenance Fee. In addition to the foregoing license execution fee, LICENSEE agrees to pay to BCM, upon receipt of an invoice from BCM, an annual non-refundable maintenance fee of
[*...***...] DOLLARS ($[...***...] USD), due upon each anniversary of the Agreement Date, beginning on the second anniversary of the Agreement Date. The annual maintenance fee
obligation terminates upon the first commercial sale of a Licensed Product. 
 4.3 Responsibility for Legal Costs. In addition to the
foregoing license execution fee, LICENSEE shall be responsible for all Legal Costs incurred by BCM after the Agreement Date. 
 4.4
Royalty on Net Sales. In addition to the foregoing payments and responsibilities described in Sections 4.1-4.3, LICENSEE shall pay BCM a royalty of [...***...] percent ([...***...]%) of Net Sales. Collectively the royalty payments
that are the subject of this Section 4.4 are termed “Royalties” for purposes of this Agreement, and shall be due and payable as provided in Section 5 and shall be delivered to BCM in accordance with the invoice instructions
provided below. 
 4.5 Annual Minimum Royalty. In the event that the Royalties paid in any full calendar year after the first
commercial sale of a Licensed Product do not reach the minimum amount set out below for such year, then within [...***...] days after the end of such full calendar year LICENSEE shall pay an additional amount for the period ending
December 31 of such year, so that the total amount paid to BCM under Section 4.4 and this Section 4.5 for such year shall reach such minimum amount: 
  

	 	(i)	[...***...] DOLLARS ($[...***...] USD) in the first full calendar year following the first commercial sale of Licensed Product; 

 

	 	(ii)	[...***...] DOLLARS ($[...***...] USD) in the second full calendar year following the first commercial sale of a Licensed Product; and 

 

	 	(iii)	[...***...] DOLLARS ($[...***...] USD) in the third full calendar year following the first commercial sale of a Licensed Product and thereafter during the Term of this Agreement for each subsequent full
calendar year. 

 4.6 Milestone Payments. LICENSEE shall also pay BCM the following milestone payments set forth below:

  

	 	(i)	Initiation of a first Phase III clinical trial of a first Licensed Product, [...***...] DOLLARS ($[...***...] USD); and 

  

	 	(ii)	First Regulatory Agency – Approved Commercial Sale of a first Licensed Product, [...***...] DOLLARS ($[...***...] USD). 

LICENSEE shall notify BCM in writing within [...***...] days upon the achievement of each milestone, such notice to be accompanied by payment of the
appropriate milestone payment. Milestones are to be paid regardless of whether LICENSEE or LICENSEE’s sublicensee attains such milestone. 

4.7 Sublicense Revenue Payments. In the event LICENSEE grants a sublicense, grants access to, or allows the use of Patent Rights, under
this Agreement, LICENSEE agrees to pay to BCM 

  
  

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	 	(i)	[...***...] percent ([...***...]%) of all Sublicensing Revenue received by LICENSEE before the date of initiation of the first Phase II clinical
trial of a first Licensed Product; and 

  

	 	(ii)	[...***...] percent ([...***...]%) of all Sublicensing Revenue received by LICENSEE on or after the date of initiation of the first Phase II clinical trial of a first Licensed Product. 

4.8 Payment Addresses. Payments sent by check are to be made payable to “Baylor College of Medicine” and shall be sent to the
address below. If payments are sent by wire transfer, they shall be sent using wiring instructions provided in Appendix C. All payments shall reference BLG number(s) 13-040 (as listed on the front page of the Agreement). 

 

							
	BCM Tax ID #: 74-1613878	  		  	
	Baylor College of Medicine	  		  	
	Licensing Group	  		  	
	 P.O. Box 301503
 Dallas, Texas
75303-1503
	  		  	
				
	Telephone No.	 	 713-798-6821
	  		  	
	Facsimile No.	 	 713-798-1252
	  		  	
	E-Mail	 	 blg@bcm.tmc.edu
	  		  	

 Payments shall be deemed received only upon confirmation that all funds have been received by the LICENSING
GROUP as referenced above. LICENSEE hereby accepts responsibility for ensuring that each payment is addressed correctly. 
 Licensee
Payment Contact. For questions about payments, BCM can contact LICENSEE at the address below: 
  

							
	Title	 	 VP IP & Legal Affairs
	  		  	
	Name	 	 Ken Moseley
	  		  	
	Address	 	 Bellicum Pharmaceuticals, Inc.
	  		  	
		 	 2130 W. Holcombe Blvd.

Suite 850
 Houston, TX
77030
	  		  	
				
	Telephone No.	 	 832-384-1107
	  		  	
	Facsimile No.	 	 832-384-1150
	  		  	
	E-Mail	 	 kmoseley@bellicum.com
	  		  	

 4.9 Payment Conditions. All payments due hereunder are payable in United States dollars. No transfer,
exchange, collection or other charges, including any wire transfer fees, shall be deducted from such payments. For sales of Licensed Products in currencies other than the United States, LICENSEE shall use exchange rates published in
[...***...] on the last business day of the month preceding the calendar quarter for which such payment is due. 
 4.10 Late
Payments. Late payments that are overdue by thirty (30) days or more may be subject to a charge of [...***...] percent ([...***...]%) per month on the unpaid, undisputed amount, the interest being compounded annually. LICENSEE
shall calculate the correct late payment charge, and shall add it to each such late payment. LICENSEE’s payment of a late payment shall not negate or waive the right of BCM to seek any other remedy, legal or equitable, to which it may be
entitled because of the delinquency of any payment 

  
  

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	5.	REPORTING 

 5.1 Annual Progress Report. No later than [...***...] after December 31 of each calendar year, LICENSEE shall provide to BCM a written annual progress report describing progress on all research and development and commercial
activities related to Licensed Products, during the most recent twelve (12) month period ending December 31 and plans for the forthcoming year (“Annual Progress Report”). If multiple technologies are covered by the license
granted hereunder, the progress report shall provide the information set forth above for each technology. At BCM’s request, LICENSEE shall also provide any reasonable additional data BCM requires to evaluate LICENSEE’s or its
sublicensees’ diligence obligations under Section 3. 
 5.2 Notification of First Sale. LICENSEE shall notify BCM in
writing of the date on which LICENSEE or the sublicensees make a first commercial sale of a first Licensed Product, such notification to be delivered within [...***...] days of occurrence. 

5.3 Royalty Reports; Other Payment Reports. From and after the date of first commercial sale of a Licensed Product, LICENSEE shall
submit to BCM within [...***...] after March 31, June 30, September 30 and December 31, a written Royalty report on a form provided by BCM (a current version of which is attached as Appendix B) setting
forth for such calendar quarter at least the following information: 
 (i) the number of Licensed Products sold by LICENSEE and sublicensees; 

(ii) total gross amount of consideration received from sales of such Licensed Products; 

(iii) the identity of non-cash consideration which is received and reported pursuant to the foregoing clause (ii); 

(iv) deductions from the gross amount reported pursuant to the foregoing clause (ii), as expressly permitted herein to determine the Net Sales thereof; and

 (v) the amount of Royalties due thereon, or, if no Royalties are due to BCM for any reporting period after LICENSEE’s Royalty reporting obligation
under this Section 5.3 has commenced, the statement that no Royalties are due. 
 Both before and after the date of first commercial sale of a Licensed
Product, LICENSEE shall submit to BCM within [...***...] after March 31, June 30, September 30 and December 31, a written report of (a) the amount of Sublicensing Revenue received by LICENSEE, and the amount
owed thereon pursuant to Section 4.7; and (b) the amount of other payments that became due to BCM in such calendar quarter, including but not limited to, milestone payments pursuant to Section 4.6, minimum royalty payment (if any)
pursuant to Section 4.5, and annual maintenance fee payment (if applicable) pursuant to Section 4.2. 
 The Royalty report shall
be certified as correct by an officer of LICENSEE. After termination or expiration of this Agreement, LICENSEE will continue to submit Royalty reports and payments to BCM until all products that were Licensed Products under the Agreement at the time
of expiration or termination have been sold. 
 5.4 Payment to Accompany Royalty Reports. LICENSEE shall pay to BCM with each such
royalty report the amount of Royalties and other unpaid amounts then due with respect to such calendar quarter. LICENSEE shall include in each royalty report the applicable BLG number listed on the front page of the Agreement. 

  
  

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 5.5 Notification of Merger or Acquisition. In the event of acquisition, merger, change of
corporate name, or change of make-up, organization, or identity, LICENSEE shall notify BCM in writing within [...***...] days of such event. 

 

	6.	ENTITY STATUS 

 If LICENSEE or any sublicensee does not qualify as a “small entity” as
provided by the United States Patent and Trademark Office, LICENSEE must notify BCM promptly of such circumstance. 
  

	7.	RECORDS AND INSPECTION 

 7.1 Accounting Records. LICENSEE shall maintain, and
shall cause its sublicensees to maintain, complete and accurate records relating to any amounts payable to BCM in relation to this Agreement, which records shall contain sufficient information to permit BCM to confirm the accuracy of any financial
reports delivered to BCM. The relevant party (LICENSEE or sublicensee) shall retain such records for at least three (3) years following the end of the calendar year to which they pertain. 

7.2 Audit by BCM. During the Term of this Agreement as defined below and for a period of [...***...] thereafter, and upon no less
than thirty (30) days’ advance written notice, LICENSEE will permit a certified public accountant engaged by BCM and reasonable acceptable to LICENSEE, provided such acceptance shall not be unreasonably delayed, denied, or conditioned, to
inspect the financial books and records of LICENSEE to confirm the accuracy of any royalty reports delivered to BCM pursuant to Section 5.3. LICENSEE agrees to provide such BCM accountant reasonable access during ordinary working hours to
permit inspection of LICENSEE’s financial books, records, systems and processes, and shall reasonably cooperate with BCM’s accountant in support of his/her inspection activities. If BCM’s accountant reasonably determines, after any
such inspection of LICENSEE’s financial books, records, systems and processes, that the books and records of any sublicensee should be inspected, BCM may request in writing that LICENSEE conduct such inspection of LICENSEE’s sublicensee,
and LICENSEE shall conduct such inspection within sixty (60) days after LICENSEE receives such written request of BCM, and shall report the results of such inspection to BCM’s accountant. BCM’s accountant will enter into an
appropriate confidentiality agreement with LICENSEE that is satisfactory to LICENSEE. The accountant shall provide a copy of his/her inspection report to BCM and to LICENSEE. The accountant shall not disclose to BCM any information relating to the
business of LICENSEE or its sublicensees except that which is necessary to inform BCM of: (i) the accuracy or inaccuracy of LICENSEE’s royalty reports and payments under this Agreement; (ii) information concerning any payments owed by
LICENSEE for any period, in the case of failure of LICENSEE to report or make payment pursuant to this Agreement; and (iii) the extent of any such inaccuracy or payments owed. 

7.3 Payment Deficiency. If a payment deficiency is determined by BCM’s accountant pursuant to Section 7.2, and LICENSEE does
not dispute such finding of a payment deficiency, LICENSEE shall pay the outstanding deficient amount within [...***...] days of receiving written notice thereof, plus (if applicable and invoiced by BCM) interest on such outstanding deficient
amount as described in Section 4.10. 
 7.4 Responsibility for Audit Costs. BCM will pay for any audit done under
Section 7.2. However, in the event that the audit reveals an undisputed underpayment of Royalties or fees by more than [...***...] percent ([...***...]%) for the period being audited, then the reasonable, out-of-pocket cost of such
audit shall be paid by LICENSEE. 

  
  

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	8.	SUBLICENSES 

 All sublicenses granted by LICENSEE of its license rights hereunder shall
be subject to the terms of this Agreement. LICENSEE shall be responsible for its sublicensees and shall not grant any rights which are inconsistent with the rights granted to and obligations of LICENSEE hereunder. Any act or omission of a
sublicensee which would be a breach of this Agreement if performed by LICENSEE shall be deemed to be a breach by LICENSEE of this Agreement. No such sublicense agreement shall contain any provision which would cause it to extend beyond the Term of
this Agreement as defined below (except with respect to those terms and conditions which are specifically identified as surviving the termination or expiration of the Agreement). LICENSEE shall give BCM prompt notification of the identity and
address of each sublicensee with whom it concludes a sublicense agreement and shall supply BCM with a copy of each such sublicense agreement; provided that LICENSEE may redact portions of such sublicense agreement which do not pertain to a
sublicense of LICENSEE’s rights and obligations under this Agreement. 
  

	9.	PATENTS AND INFRINGEMENT 

 9.1 Patent Prosecution Responsibility. For the Term of
this Agreement as defined below, LICENSEE shall be responsible for filing, prosecuting and maintaining all patent applications and patents included in the Patent Rights, and LICENSEE agrees to pay all Legal Costs. BCM will reasonably cooperate with
LICENSEE regarding such activities related to the Patent Rights. Should BCM incur any Legal Costs, LICENSEE agrees to pay invoices for such Legal Costs within [...***...] days of
receipt. 
 9.2 Notification of Intent Not to Pursue. In the event that LICENSEE decides not to file, prosecute or maintain any
patent application or patent within the Patent Rights (a “Discontinued Patent”), LICENSEE shall timely notify BCM in writing thereof. LICENSEE’s right under this Agreement to practice the Discontinued Patent shall immediately
terminate upon the giving of such notice, and such Discontinued Patent shall be removed from the definition of Patent Rights. Thereafter, BCM may file, prosecute and/or maintain such Discontinued Patent, at its own expense, If LICENSEE fails to
notify BCM in reasonably sufficient time for BCM to assume such filing, prosecution and/or maintenance of said Discontinued Patent, LICENSEE shall be considered in default of this Agreement. 

9.3 Notification of Patent Prosecution Action. LICENSEE agrees to keep BCM fully informed, at [...***...]’s expense, of all
prosecutions and other actions pursuant to this Section 9, including submitting to BCM copies of all official actions in patent offices and responses thereto. 

9.4 Cooperation. BCM agrees to reasonably cooperate with LICENSEE to whatever extent is reasonably necessary to provide LICENSEE the
full benefit of the license granted herein. 
 9.5 Infringement Procedures. During the Term of this Agreement as defined below, each
Party shall promptly inform the other of any suspected infringement of any claims in the Patent Rights or the misuse, misappropriation, theft or breach of confidence of other proprietary rights in Patent Rights by a third party, and with respect to
such activities as are suspected. Any action or proceeding against such third party shall be instituted as following: 
 (i) BCM and LICENSEE may agree to
jointly institute an action for infringement, misuse, misappropriation, theft or breach of confidence of the proprietary rights against such third party (“Infringement Action”). Such joint Infringement Action shall be brought in the names
of both BCM and LICENSEE. LICENSEE and BCM shall agree to the manner in which they shall exercise control over any joint Infringement Action, providing however that if they cannot agree BCM shall have the right to 

  
  

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unilaterally decide on control (and in such event, LICENSEE may withdraw as a party to such Infringement Action). In such joint Infringement Action, the out-of-pocket costs shall be borne
equally, and any recovery or settlement shall be shared equally. 
 (ii) If LICENSEE does not agree to participate in a joint Infringement Action, then BCM
shall have the right, but not the obligation, to institute an Infringement Action on its own and in its own name. If BCM fails to bring such an Infringement Action within a period of three (3) months after receiving notice or otherwise having
knowledge of such infringement, then LICENSEE shall have the right, but not the obligation, to prosecute the same at its own expense and in its own name; BCM will reasonably cooperate with LICENSEE in such Infringement Action. In addition, if BCM
cooperates in such Infringement Action at LICENSEE’s request, such cooperation shall be at LICENSEE’s sole expense. 
 (iii) If BCM does not agree
to participate in a joint Infringement Action, then LICENSEE shall have the right, but not the obligation, to institute an Infringement Action on its own and in its own name. If LICENSEE fails to bring such an Infringement Action within a period of
three (3) months after receiving notice or otherwise having knowledge of such infringement, then BCM shall have the right, but not the obligation, to prosecute the same at its own expense and in its own name; LICENSEE will reasonably cooperate
with BCM in such Infringement Action. In addition, if LICENSEE cooperates in such Infringement Action at BCM’s request, such cooperation shall be at BCM’s sole expense. 

(iv) Should either BCM or LICENSEE commence an Infringement Action under the provisions of this Section 9.5 and thereafter elect to abandon the same, it
shall give timely notice to the other Party who may, if it so desires, continue prosecution of such Infringement Action. All recoveries, whether by judgment, award, decree or settlement, from infringement or misuse of Patent Rights shall be
apportioned as follows: (a) the Party bringing the Infringement Action shall first recover a reasonable amount equal the costs and expenses incurred by such Party directly related to the prosecution of such Infringement Action, (b) the
Party cooperating in such Infringement Action shall then recover reasonable costs and expenses incurred by such Party, if any, directly related to its cooperation in the prosecution of such Infringement Action and (c) the remainder shall be
divided equally between LICENSEE and BCM. 
 9.6 Consent to Settle. Neither BCM nor LICENSEE shall settle any Infringement Action
covered by Section 9.5 without first obtaining the consent of the other Party, which consent will not be unreasonably withheld, conditioned or delayed. 

9.7 Liability for Losses. BCM shall not be liable for any losses incurred as the result of an action for infringement brought by a
third party against LICENSEE as the result of LICENSEE’s exercise of any right granted under this Agreement. The decision to defend or not defend such third-party action for infringement shall be in LICENSEE’s sole discretion. 

9.8 Statement Regarding Patent Rights. To the knowledge of BCM’s Licensing Group, (i) BCM owns all right, title and interest
in and to the Patent Rights (with the exception of certain retained rights of the United States Government, as described in Section 2.3); (ii) inventors of the Patent Rights have been properly named; (iii) it has the authority to
enter into this Agreement and grant the licenses to LICENSEE as set forth hereunder. 
  

	10.	TERM  

 Unless sooner terminated as otherwise provided in Section 11, the license
to employ Patent Rights granted to LICENSEE herein shall expire on a country-by-country basis, on the date of expiration of the last of the Patent Rights to expire (“Term”). After such expiration, but not termination, LICENSEE shall have a
perpetual, paid-in-full (i.e., royalty free) license. 

  
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	11.	TERMINATION 

 11.1 Termination for Default. In the event of default or failure by
LICENSEE to perform any of the terms, covenants or provisions of this Agreement, including failure to make timely payment, LICENSEE shall have thirty (30) days after receipt of written notice from BCM describing such default or failure and
demanding its cure in which to correct such default or failure. If such default or failure is not corrected within the said thirty (30) day period, BCM shall have the right, at its option, to cancel and terminate this Agreement by delivery to
LICENSEE of a written notice of termination. The failure of BCM to exercise such right of termination, for non-payment of Royalties/ fees or other non-payment, after delivering a notice of default or failure shall not be deemed to be a waiver by BCM
of any other right BCM might have, nor shall such failure of BCM to exercise such right of termination preclude BCM from exercising or enforcing said right in accordance with this Section 11.1 upon any subsequent default or failure by LICENSEE.

 11.2 Termination for Default of Diligence Obligations. Notwithstanding anything to the contrary in Section 11.1, if LICENSEE
materially breaches or fails to perform one or more of its diligence obligations under Section 3, BCM may deliver to LICENSEE a written notice of default (which notice shall specify in reasonable detail the default). The Parties shall
thereafter consult concerning the alleged default, and BCM then may provide written notice of BCM’s intent to terminate LICENSEE’s rights under this Agreement, if the default has not been cured in full within ninety (90) days. In the
event of any default which is not reasonably capable of remedy within such ninety (90)-day period, LICENSEE shall provide to BCM a written proposal for such remedy (including a reasonable time period which shall not extend beyond one (1) year
for completion thereof), and then if LICENSEE has not commenced or has not diligently pursued such remedy within such reasonable time period, BCM may terminate this Agreement effective immediately upon receipt of written notice. 

11.3 Termination for Insolvency. BCM shall have the right, at its option, to cancel and terminate this Agreement in the event that
LICENSEE shall (i) become insolvent, undergo dissolution, or initiate bankruptcy or receivership proceedings affecting the operation of its business or (ii) make an assignment of all or substantially all of its assets for the benefit of
creditors, or in the event that (iii) a receiver or trustee is appointed for LICENSEE and LICENSEE shall, after the expiration of thirty (30) days following any of the events enumerated above, have been unable to secure a dismissal, stay
or other suspension of such proceedings. 
 11.4 Termination by Licensee. LICENSEE shall have the right in its sole discretion to
terminate this Agreement upon sixty (60) days’ written notice to BCM. 
 11.5 Effect of Termination. In the event of
termination of this Agreement, all rights to Patent Rights shall revert to BCM. At the date of any termination of this Agreement, LICENSEE shall immediately cease using and exploiting any Valid Claims; provided, however, that LICENSEE and its
sublicensees may sell any Licensed Products actually in the possession of LICENSEE or its sublicensees on the date of termination, provided that LICENSEE continues to submit royalty reports to BCM and pays to BCM the Royalties on all such sales in
accordance with Section 5.3 with respect thereto and otherwise complying with the terms of this Agreement. 
 11.6 Effect of
Termination on Sublicensees. Notwithstanding Section 11.5 to the contrary, at any time within thirty (30) days following termination of this Agreement, a sublicensee under this Agreement may notify BCM that it wishes to enter into a direct
license with BCM (with the same effective date as the date of termination of this Agreement) in order to retain its continuous rights to the Patent Rights granted to it under its sublicense with LICENSEE (such 30-day period following

  
 -11- 

 
termination, the “Initial Notice Period”). Following receipt of such notice, BCM and such sublicensee shall enter into a license agreement the terms of which shall be
substantially similar to the terms of this Agreement; provided, however, that the scope of such direct license, the licensed territory and/or the duration of the license grant may be more limited than the corresponding terms granted to LICENSEE
hereunder (for example, if such sublicense provided for such limited terms and/or if multiple sublicensees seek such direct licenses with BCM); and provided such sublicensee shall provide BCM in writing notification that such sublicensee is in good
standing with respect to the sublicensing rights; and further provided that such sublicensee will be granted at least the same scope of rights as it obtained under its sublicense. For the sake of clarity, the financial terms, including without
limitation, the royalty rate and milestone payments, shall be identical to the corresponding financial terms set forth in this Agreement; provided, however, that milestone payment amounts that would have been paid by LICENSEE to BCM under this
Agreement will be allocated in a pro rata fashion in the event that there are multiple sublicensees. 
 11.7 No Refund. In the event
this Agreement is terminated pursuant to this Section 11, or expires as provided for in Section 10, BCM is under no obligation to refund any payments made by LICENSEE to BCM, or due to BCM, prior to the effective date of such termination
or expiration. 
 11.8 Survival of Termination. No termination of this Agreement shall constitute a termination or a waiver of any
rights of either Party against the other Party accruing at or prior to the time of such termination. The obligations of Sections 4 (regarding payment obligations that accrued during the Term), 5.3, 5.4, 7, 11.5, 11.6, 11.7, 11.8, 13, 14, 15, 16, 17
and 18 shall survive expiration or termination of this Agreement. 
  

	12.	ASSIGNABILITY 

 Without the prior written approval of BCM, which will not be
unreasonably withheld, conditioned or delayed, this Agreement and LICENSEE’s rights and obligations hereunder shall not be assigned in whole or in part by LICENSEE to any person or entity whether voluntarily or involuntarily, by operation of
law or otherwise. Notwithstanding the foregoing, LICENSEE may assign this Agreement and its rights and obligations hereunder without BCM’s consent, (i) in connection with the transfer or sale of all or substantially all of its assets or
the business of LICENSEE to which this Agreement relates or (ii) to any Affiliate; so long as LICENSEE gives BCM prompt notice of such action and the successor entity or Affiliate, i.e., the assignee (as the case may be), acknowledges its
consent and agreement to the terms of this Agreement in writing within [...***...] business days of such assignment; and so long as such assignment is not entered into solely to
satisfy creditors of LICENSEE. This Agreement shall be binding upon and shall inure to the benefit of the respective successors, legal representatives and assignees of each of the Parties. 

 

	13.	GOVERNMENTAL COMPLIANCE 

 13.1 Compliance with Applicable Laws. LICENSEE shall at
all times during the Term of this Agreement and for so long as it shall use Valid Claims of Patent Rights, or sell Licensed Products, comply and cause its sublicensees to comply with all laws that may control the import, export, manufacture, use,
sale, marketing, distribution and other commercial exploitation of Patent Rights, Licensed Products or any other activity undertaken pursuant to this Agreement. 

13.2 Requirement for U.S. Manufacture. To the extent required by 35 USC § 204 (if applicable), LICENSEE agrees that Licensed
Products embodying or produced through the use of an invention that is subject to the rights of the federal government of the United States of America and that are leased or sold in the United States shall be manufactured substantially in the United
States (unless a waiver under 35 USC § 204 or equivalent is granted by the appropriate United States government agency); provided that should LICENSEE decide to seek a waiver of this requirement, BCM shall reasonably cooperate with LICENSEE in
seeking such waiver. 

  
  

***Confidential Treatment Requested 

-12- 

 13.2.1 To the extent LICENSEE requests BCM to cooperate with LICENSEE in seeking such a waiver,
upon LICENSEE’s written request, and at LICENSEE’s expense, BCM shall use reasonable efforts to apply to the applicable United States governmental agency for a waiver to such requirements; provided, however, that all reasonable costs
incurred by BCM in the preparation and application of the waiver, including the reasonable costs of any action undertaken by BCM or its counsel that is necessary to satisfy any governmental agency’s request regarding such waiver, shall be
paid by LICENSEE within thirty (30) days following receipt of BCM’s invoice or BCM counsel’s invoice for such costs. LICENSEE agrees that it will reasonably cooperate with BCM in such application and provide any information
reasonably requested by BCM for such application. LICENSEE understands and agrees that such waivers are not guaranteed to be granted. 

13.3 Export Control Regulations. The Patent Rights are subject to, and LICENSEE agrees to comply in all respects with, all applicable
U.S. export laws, including but not limited to U.S. export controls under the Export Administration Regulations (15 C.F.R. Part 734 et seq.) and U.S. economic sanctions and embargoes codified in 31 C.F.R. Chapter V. LICENSEE agrees that LICENSEE
bears sole responsibility for understanding and complying with current U.S. trade controls laws and regulations as applicable to its activities subject to this Agreement. Without limitation on the general agreement to comply set forth in the first
sentence of this Section 13.3, LICENSEE agrees not to sell any goods, services, or technologies subject to this Agreement, or to release or disclose or re-export the same: (i) to any destination prohibited by U.S. law, including any
destination subject to U.S. economic embargo; (ii) to any end-user prohibited by U.S. law, including any person or entity listed on the U.S. government’s Specially Designated Nationals list, Denied Parties List, Debarred Persons List,
Unverified List, or Entities List; (iii) to any foreign national in the U.S. or abroad without prior license if required; or (iv) to any user, for any use, or to any destination without prior license if required by the US Government.
Furthermore, LICENSEE agrees that any transfer of Patent Rights from BCM to LICENSEE under this Agreement may be subject to U.S. export license authorization as may be required under U.S. law. 

 

	14.	DISPUTE RESOLUTION 

 14.1 Amicable Resolution. The Parties shall attempt to
settle any dispute or controversy between them (“Dispute”) amicably. To this end, a senior executive from each Party shall consult and negotiate to reach a resolution of such Dispute. The Parties agree that the period of amicable
resolution shall toll any otherwise applicable statute of limitations. 
 14.2 Failure to Amicably Resolve. If the senior executives
from each Party fail to meet or if the Dispute remains unresolved for a period of [...***...] days after commencing senior executive negotiations, then the Parties may mutually agree to resolve such Dispute through other informal
procedural means, including, but not limited to, referral to an independent, neutral third party expert, mediation, arbitration and/or any other procedure(s) upon which the Parties mutually agree. Each Party agrees that, prior to resorting to
litigation to resolve any Dispute, it will confer in good faith with the other Party to determine whether other procedures that are less expensive or less time consuming can be adopted to resolve the Dispute. 

14.3 Construction and Jurisdiction. This Agreement shall be governed by, and shall be construed and interpreted in accordance with, the
laws of the State of Texas. 

  
  

***Confidential Treatment Requested 

-13- 

	15.	NOTICES 

 15.1 Addresses for Notices. All notices, reports or other
communications pursuant to this Agreement shall be sent to such Party via (i) United States Postal Service first class postage prepaid, return receipt requested, or (ii) overnight courier, or (iii) personal delivery addressed to the
addressee Party at its address set forth below or as it shall designate by written notice given to the other Party. Notice shall be sufficiently made or given upon delivery to the addressee Party during normal hours of a business day. 

In the case of BCM: 
 Patrick
Turley 
 Associate General Counsel 

Baylor College of Medicine 
 One
Baylor Plaza, BCM210-600D 
 Houston, TX 77030 

Telephone No.    713-798-6821 

Facsimile No.     713-798-1252 

In the case of LICENSEE: 

Title      President & CEO 

Name    Thomas J. Farrell 

Address Bellicum Pharmaceuticals, Inc. 

              2130 W. Holcombe Blvd. Suite 850 

              Houston, TX 77030 

Telephone No.    832-384-1107 

Facsimile No.     832-384-1150 

15.2 Use of Reference Number. Each such report, notice or other communication shall include BLG number(s) 13-040 listed on the
front page of the Agreement. 
  

	16.	INDEMNITY, INSURANCE & WARRANTIES 

 16.1 Indemnity. 

(I) EACH PARTY SHALL NOTIFY THE OTHER OF ANY CLAIM, LAWSUIT OR OTHER PROCEEDING RELATED TO PATENT RIGHTS. LICENSEE AGREES THAT IT WILL DEFEND, INDEMNIFY
AND HOLD HARMLESS BCM, ITS FACULTY MEMBERS, SCIENTISTS, RESEARCHERS, EMPLOYEES, STUDENTS, OFFICERS, TRUSTEES AND AGENTS AND EACH OF THEM (THE “INDEMNIFIED PARTIES”), FROM AND AGAINST ANY AND ALL THIRD PARTY CLAIMS, CAUSES OF ACTION,
LAWSUITS OR OTHER PROCEEDINGS (THE “BCM CLAIMS”) FILED OR OTHERWISE INSTITUTED AGAINST ANY OF THE INDEMNIFIED PARTIES RELATED DIRECTLY TO OR ARISING OUT OF THE DESIGN, PROCESS, MANUFACTURE OR USE OF PATENT RIGHTS, LICENSED PRODUCTS OR ANY
OTHER EMBODIMENT OF PATENT RIGHTS (INCLUDING, BUT NOT LIMITED TO, THE PAYMENT OF ALL REASONABLE ATTORNEYS’ FEES AND COSTS OF LITIGATION OR OTHER DEFENSE); PROVIDED, HOWEVER, THAT SUCH INDEMNITY OBLIGATION SHALL NOT APPLY TO ANY BCM CLAIMS
ARISING FROM THE GROSS NEGLIGENCE OR INTENTIONAL MISCONDUCT OF ANY INDEMNIFIED PARTY. LICENSEE WILL ALSO ASSUME RESPONSIBILITY FOR ALL COSTS AND EXPENSES 

  
 -14- 

 
RELATED TO SUCH BCM CLAIMS FOR WHICH IT IS OBLIGATED TO INDEMNIFY THE INDEMNIFIED PARTIES PURSUANT TO THIS SECTION 16.1, INCLUDING, BUT NOT LIMITED TO, THE PAYMENT OF ALL REASONABLE
ATTORNEYS’ FEES AND COSTS OF LITIGATION OR OTHER DEFENSE. 
 (ii) LICENSEE SHALL HAVE SOLE DISCRETION IN ASSUMING THE DEFENSE OF A BCM CLAIM.
UPON CHOOSING TO ASSUME SUCH DEFENSE, LICENSEE SHALL SEND A NOTICE OF THE ASSUMPTION TO BCM. AFTER SENDING THE NOTICE, LICENSEE SHALL CHOOSE AND EMPLOY LEGAL COUNSEL OF REPUTABLE STANDING AND MAY CONTEST, PAY, SETTLE OR COMPROMISE THE BCM CLAIM AS
IT MAY DETERMINE, SUBJECT TO THE PROVISIONS OF SECTION 16.1(iv). LICENSEE’S ASSUMPTION OF THE DEFENSE OF THE BCM CLAIM DOES NOT CONSTITUTE AN ADMISSION BY LICENSEE THAT IT IS REQUIRED TO INDEMNIFY BCM FOR THE BCM CLAIM. 

(iii) LICENSEE SHALL HAVE NO OBLIGATION TO INDEMNIFY BCM UNDER THIS SECTION 16 IF BCM FAILS TO NOTIFY LICENSEE IN WRITING WITHIN TWENTY (20) BUSINESS
DAYS AFTER BCM’S RECEIPT OFWRITTEN NOTICE OF THE BCM CLAIM. 
 (iv) LICENSEE FURTHER AGREES NOT TO SETTLE ANY CLAIM AGAINST AN INDEMNIFIED PARTY
WITHOUT THE INDEMNIFIED PARTY’S WRITTEN CONSENT WHICH CONSENT SHALL NOT BE UNREASONABLY WITHHELD, CONDITIONED OR DELAYED. UPON BCM’S WRITTEN REQUEST, LICENSEE FURTHER AGREES TO KEEP THE INDEMNIFIED PARTIES REGULARLY APPRISED OF THE BCM
CLAIMS. 
 (v) FOR THE AVOIDANCE OF DOUBT AND NOTWITHSTANDING ANYTHING TO THE CONTRARY IN THIS AGREEMENT, LICENSEE SHALL HAVE NO INDEMNIFICATION
OBLIGATION WHATSOEVER FOR THE POSSESSION OR USE BY BCM, ITS FACULTY MEMBERS, DEVELOPERS, SCIENTISTS, RESEARCHERS, EMPLOYEES, STUDENTS, OFFICERS, TRUSTEES, AGENTS, TRANSFEREES OR COLLABORATORS OF LICENSED PRODUCTS OR ANY OTHER EMBODIMENT OF THE
PATENT RIGHTS. 
 16.2 Insurance. 

(i) Until LICENSEE receives commercialization approval from a national regulatory body for a Licensed Product, LICENSEE shall for so long as LICENSEE
manufactures or, uses any Licensed Product(s), maintain in full force and effect policies of (a) worker’s compensation insurance within statutory limits, (b) employers’ liability insurance with limits of not less than
[...***...] dollars ($[...***...]) per occurrence, (c) general liability insurance (with Broad Form General Liability endorsement) with limits of not less than [...***...] dollars ($[...***...]) per occurrence
with an annual aggregate of [...***...] dollars ($[...***...]) and (d) products liability insurance, with limits of not less than [...***...] dollars ($[...***...]) per occurrence with an annual aggregate of
[...***...] dollars ($[...***...]). 
 (ii) At such time that LICENSEE receives commercialization approval from a national regulatory body for a
Licensed Product, LICENSEE shall for so long as LICENSEE manufactures, uses or sells any such Licensed Product(s), maintain in full force and effect policies of (a) worker’s compensation insurance within statutory limits,
(b) employers’ liability insurance with limits of not less than [...***...] dollars ($[...***...]) per occurrence, (c) general liability insurance (with Broad Form General Liability endorsement) with

  
  

***Confidential Treatment Requested 

-15- 

 
limits of not less than [...***...] dollars ($[...***...]) per occurrence with an annual aggregate of [...***...] dollars ($[...***...]) and (d) products liability
insurance, with limits of not less than [...***...] dollars ($[...***...]) per occurrence with an annual aggregate of [...***...] dollars ($[...***...]). 

(iii) Such coverage(s) shall be purchased from a carrier or carriers having an A. M. Best rating of at least A- (A minus) and shall name BCM as an additional
insured. LICENSEE shall provide to BCM copies of certificates of insurance within [...***...] days after execution of this Agreement. Upon request by BCM, LICENSEE shall provide to BCM copies of said policies of insurance. It is the intention
of the Parties hereto that LICENSEE shall, throughout the Term of this Agreement, continuously and without interruption, maintain in force the required insurance coverages set forth in this Section 16.2. Failure of LICENSEE to comply with this
requirement shall constitute a default of LICENSEE allowing BCM, at its option, to immediately terminate this Agreement. 
 (iii) BCM reserves the right to
request additional policies of insurance where appropriate and reasonable in light of LICENSEE’s business operations and availability of coverage. 

16.3 DISCLAIMER OF WARRANTY. BCM MAKES NO WARRANTIES OR REPRESENTATIONS, EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, WARRANTIES OF
FITNESS OR MERCHANTABILITY, REGARDING OR WITH RESPECT TO PATENT RIGHTS OR LICENSED PRODUCTS AND BCM MAKES NO WARRANTIES OR REPRESENTATIONS, EXPRESS OR IMPLIED, OF THE PATENTABILITY OF PATENT RIGHTS OR LICENSED PRODUCTS OR OF THE ENFORCEABILITY OF
ANY PATENTS ISSUING THEREUPON, IF ANY, OR THAT PATENT RIGHTS OR LICENSED PRODUCTS ARE OR SHALL BE FREE FROM INFRINGEMENT OF ANY PATENT OR OTHER RIGHTS OF THIRD PARTIES. NOTHING IN THIS AGREEMENT SHALL BE CONSTRUED AS CONFERRING BY IMPLICATION,
ESTOPPEL OR OTHERWISE ANY LICENSE OR RIGHTS UNDER ANY PATENTS OF BCM OTHER THAN THE PATENT RIGHTS REGARDLESS OF WHETHER SUCH PATENTS ARE DOMINANT OR SUBORDINATE TO THE PATENT RIGHTS. 

 

	17.	CONFIDENTIALITY 

 17.1 Scope. The term “LICENSEE Confidential
Information” shall mean any proprietary and secret ideas, proprietary technical information, know-how and proprietary commercial information or other similar proprietary information that are owned by LICENSEE. Collectively, LICENSEE
Confidential Information and BCM Confidential Information may be referred to herein as “Confidential Information.” A receiving Party shall not disclose the other Party’s Confidential Information to any third party without the other
Party’s prior written consent, and shall not use such Confidential Information of the other Party except as permitted hereunder. Employees, agents or subcontractors of a receiving Party shall be given access to the other Party’s
Confidential Information only on a legitimate “need to know” basis and after agreeing to be bound in writing to not divulge or reveal the other Party’s Confidential Information. The public disclosure by a receiving Party with the
permission of the other Party of any one component of that which was identified as or constituted the other Party’s Confidential Information shall not prevent the other components from retaining their status as Confidential Information and the
property of the other Party 
 17.2 Exclusion. Such obligation of confidentiality imposed on the receiving Party shall not apply to
information which the receiving Party can demonstrate: (i) was at the time of disclosure in the public domain; (ii) has come into the public domain after disclosure through no act or omission of the receiving Party; (iii) was known to
the receiving Party prior to disclosure thereof by the other Party; (iv) was lawfully disclosed to the receiving Party on a non-confidential basis by a third party; (v) the receiving Party was compelled to disclose by law or legal process;
or (vi) was approved for public release by prior written permission of the other Party. 

  
  

***Confidential Treatment Requested 

-16- 

 17.3 Court Order. A receiving Party may make disclosures of the other Party’s
Confidential Information to the extent required by a Court Order or governmental body, provided the receiving Party first gives prompt, written advance notice to the other Party of such required disclosure to enable the other Party to seek a
protective order or otherwise prevent or restrict such disclosure, or to secure confidential treatment of its Confidential Information prior to its disclosure, and the receiving Party will disclose only for the sole purpose of and solely to the
extent required by law. 
 17.4 Confidentiality of Agreement. Unless otherwise provided for in this Agreement, the Parties agree that
this Agreement and its terms are to be considered Confidential Information of each Party and shall be treated as such. 
  

	18.	ADDITIONAL PROVISIONS 

 18.1 Use of Names. LICENSEE agrees that it shall not use
in any way the name of “Baylor College of Medicine” or any logotypes or symbols associated with BCM or the names of any of the scientists or other researchers at BCM without the prior written consent of BCM. BCM agrees that it shall not
use in any way the name of LICENSEE or any logotypes or symbols associated with LICENSEE or the names of any employees or agents of LICENSEE without the prior written consent of LICENSEE. 

18.2 Marking of Licensed Products. To the extent commercially feasible and consistent with prevailing business practices, LICENSEE
shall mark, and shall cause its sublicensees to mark, all Licensed Products that are manufactured or sold under this Agreement with the number of each issued patent under the Patent Rights that applies to such Licensed Product. 

18.3 BCM’s Disclaimers. Neither BCM, nor any of its faculty members, scientists, researchers, employees, students, officers,
trustees or agents assume any responsibility for the manufacture, product specifications, sale or use of Patent Rights or Licensed Products which are manufactured by or sold by LICENSEE. 

18.4 Independent Contractors. The Parties hereby acknowledge and agree that each is an independent contractor and that neither Party
shall be considered to be the agent, representative, master or servant of the other Party for any purpose whatsoever, and that neither Party has any authority to enter into a contract, to assume any obligation or to give warranties or
representations on behalf of the other Party. Nothing in this relationship shall be construed to create a relationship of joint venture, partnership, fiduciary or other similar relationship between the Parties. 

18.5 Non-Waiver. The Parties covenant and agree that if a Party fails or neglects for any reason to take advantage of any of the terms
provided for the termination of this Agreement or if a Party, having the right to declare this Agreement terminated, shall fail to do so, any such failure or neglect by such Party shall not be a waiver or be deemed or be construed to be a waiver of
any cause for the termination of this Agreement subsequently arising, or as a waiver of any of the terms, covenants or conditions of this Agreement or of the performance thereof. None of the terms, covenants and conditions of this Agreement may be
waived by a Party except by its written consent. 
 18.6 Reformation. The Parties hereby agree that neither Party intends to violate
any public policy, statutory or common law, rule, regulation, treaty or decision of any government agency or executive body thereof of any country or community or association of countries, and that if any word, sentence, paragraph or clause or
combination thereof of this Agreement is found, by a court or executive body with judicial powers having jurisdiction over this Agreement or any of the Parties hereto, in a final, unappealable order to be in violation of any such provision in any
country or community or association of countries, such words, 

  
 -17- 

 
sentences, paragraphs or clauses or combination shall be inoperative in such country or community or association of countries, and the remainder of this Agreement shall remain binding upon the
Parties hereto. In lieu of such inoperative words, sentences, paragraphs or clauses, or combination of clauses, there will be added automatically as part of this Agreement, a valid, enforceable and operative provision as close to the original
language as may be possible which preserves the economic benefits to the Parties. 
 18.7 Force Majeure. No liability hereunder shall
result to a Party by reason of delay in performance caused by force majeure, that is circumstances beyond the reasonable control of the Party, including, without limitation, acts of God, fire, flood, war, terrorism, civil unrest, labor unrest, or
shortage of or inability to obtain material or equipment. 
 18.8 Section and Paragraph Headings. The section and paragraph headings
used in this Agreement are intended for purposes of reference and convenience only, and shall not factor into any interpretation of the Agreement. 

18.8 Entire Agreement. The terms and conditions herein constitute the entire agreement between the Parties and shall supersede all
previous agreements, whether electronic, oral or written, between the Parties hereto with respect to the subject matter hereof. No agreement of understanding bearing on this Agreement shall be binding upon either Party hereto unless it shall be in
writing and signed by the duly authorized officer or representative of each of the Parties and shall expressly refer to this Agreement. Electronic communication between the Parties shall not constitute an agreement of understanding, unless it is
subsequently reduced to writing and signed by the duly authorized officer or representative of each of the Parties and shall expressly refer to this Agreement. 

18.9 No Effect on ARIAD MTAs. Nothing in this Agreement shall be construed as limiting ARIAD Pharmaceuticals’ rights under its
material transfer agreements with BCM. 

  
 -18- 

 IN WITNESS WHEREOF, the Parties hereto have executed and delivered this Agreement in multiple
originals by their duly authorized officers and representatives on the respective dates shown below, but effective as of the Agreement Date. 
  

																											
	BELLICUM PHARMACEUTICALS, INC.	 	BAYLOR COLLEGE OF MEDICINE	 	
														
	Name:  	 	 /s/ Thomas J. Farrell
	 		 		 		 		 		 	Name:  	 	 /s/ Adam Kuspa, Ph.D.
	 		 		 		 		 	
		 		 		 		 		 		 		 		 	Adam Kuspa, Ph.D.	 		 		 		 		 	
														
	Title:	 	 President & CEO
	 		 		 		 		 		 	Title:	 	Senior Vice President, Research	 		 		 		 		 	
														
	Date:	 	 11/11/14
	 		 		 		 		 		 	Date:	 	 11/6/14
	 		 		 		 		 	

 06.06.2014            Bellicum Pharmaceuticals,
Inc.            BLG # 13-040 

  
 -19- 

 Appendix A 

Patent Rights 
  

															
	 	 	 	 	 	 	 	 
	 Law

Firm Ref.  

No.
  

BCM

  Ref. No.   
  
	 	 Title and Patent Number

 
 (if issued)
	 	 Country 	 	 Inventor(s) 	 	Appln. No.	 	  Filing Date  	 	 Assignment 	 	Priority Information
	  BLG
13-   
  040   

 
	 	 Methods for Inducing Selective Apoptosis

 
	 	US	 	Malcolm Brenner	 	61/347,154	 	 May 21,

2010
	 	BCM	 	 
	  

 BLG 13-   

 040   
  
	 	 Methods for Inducing Selective Apoptosis

 
	 	PCT	 	 Malcolm  Brenner	 	PCT/ US2011/037381 	 	 May 20,

2011
	 	BCM	 	   61/347,154

 
   May 21, 2010

	  

 BLG 13-   

 040   
  
	 	 Methods for   Inducing Selective   Apoptosis

 
	 	US	 	Malcolm Brenner	 	13/112,739	 	 May 20,

2011
	 	BCM	 	   61/347,154

 
   May 21, 2010

	  

 BLG 13-   

 040   
  
	 	 Methods for Inducing Selective Apoptosis

 
	 	US	 	  Malcolm   Brenner	 	13/786,672	 	 March 6,

2013
	 	BCM	 	   61/347,154

 
   May 21, 2010

  
 -20- 

 Appendix B 

Royalty Report 
  

									
	BLG #:	 	 	 		 		 	
	Licensee:	 	 	 		 		 	
	Reporting Period:	 	 	 		 		 	
	Prepared By	 	 	 	Date:	 	 	 	
	Approved By	 	 	 	Date:	 	 	 	

 Please prepare a separate report for each product line. Then combine all product lines into a summary report. 

Product Line Code
(SKU):                                        
                             
  

															
	Country	  	
Units
 Sold
	  	Exchange
Rate	  	Gross
Amounts
Received
for Sales
(USD)	  	Less
Deductions*
(USD)	  	Net Sales
(USD)	  	Royalty
Rate	  	Royalty
Amount
	 	 	 	 	 	 	 	 
	
USA
	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	
Canada
	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	
Europe:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	
Japan
	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	
Other:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	 	 	 	 	 	 	 
	
Total
	  	 	  	 	  	 	  	 	  	 	  	 	  	$                    

		 
	     Third Party Royalty Payments (USD)
	  	$                    

	 	 
	
Net Royalty Payable (USD)
	  	$                    

	 	 
	
Sublicensing Revenue Payment (USD) 
	  	$                    

	 	 
	
Other Payments – Milestones, Minimum Royalties, Maintenance Fees (USD)
	  	 
	 	 
	
Total Payment Due (USD)
	  	$                    

 *Deduction Description: 

 APPENDIX C 

FORM OF INVOICE 
  

					
	

	 	
INVOICE                      
                  
  
	  	 Baylor Licensing Group

One Baylor Plaza
 BCM210-600D

Houston, TX 77030
 Phone:
713-798-6821
 Fax: 713-798-1252

 PLEASE NOTE CHANGE OF ADDRESS FOR ALL PAYMENTS 

DATE 
  

	RE:	    XXXXXXXXXXXXX Fee 

	    	BLG # 13-040 

 Dear: 

Please let this letter serve as an INVOICE for the XXXXXXXXXX fee of $XXXX for the above-referenced technology, as stated in the License
Agreement, between Bellicum Pharmaceuticals, Inc. and Baylor College of Medicine. 
 Please make the check payable to Baylor College of Medicine
Please address payment to the address listed below and include BLG ref 13-040 on all payments. 
 Should you choose to send payment via wire; I
have attached a copy of our wire transfer instructions for your convenience. 
 Baylor College of Medicine 

Licensing Group 
 P.O. Box 301503 

Dallas, Texas 75303-1503 
 I appreciate your attention to this
matter. 
 Best regards, 
 Nellie Villarreal 

Administrative Coordinator 
 /nv 

 ALL WIRE TRANSFER FEES ARE TO BE PAID BY THE SENDER 

(NOT BAYLOR COLLEGE OF MEDICINE). 

Wire Instructions (Incoming) 
  

					
	Company Information	  		  	
			
	Name of Company	  	Baylor College of Medicine	  	
			
	Address	  	One Baylor Plaza, M.S. BCM 203	  	
		  	 Houston, TX 77030
	  	
			
	Contact Person	  	 Linda Zoleta
	  	
			
	Phone	  	 713-798-4323
	  	
			
	BANK INFORMATION	  		  	
			
	Swift Code	  	 [*...***...] (International Wires)
	  	
			
	ABA Transit Routing Number (for wires) [...***...]	  		  	
	ABA Transit Routing Number (for ACH) [...***...]	  		  	
			
	Name of Recipient Bank	  	JPMorgan Chase Bank	  	
		  	 717 Travis, 8th Floor South
	  	
		  	 8-CBBS-302
	  	
		  	 Houston, TX 77002
	  	
			
	Bank Contact	  	 Lewis H. Gissel
	  	
	Phone	  	 713-216-0401
	  	
			
	Account Number	  	[...***...]	  	
			
	Further Credit to-	  	Baylor College of Medicine, General Acct.	  	
			
	Reference	  	Baylor Licensing Group —BLG# 13-040	  	

 PLEASE NOTE: 

Once the money is wired, we need prompt notification (email and/or fax) to the attention 

of Nellie Villarreal of the date and amount that was wired. The email is blg@bcm.edu, and 

the fax number is 713-798-1252. 

  
  

***Confidential Treatment RequestedEX-10.21

 Exhibit 10.21 

LEASE AGREEMENT 
 LIFE
SCIENCE PLAZA 
 2130 WEST HOLCOMBE BOULEVARD 

HOUSTON, TEXAS 
 BY AND
BETWEEN 
 SHERIDAN HILLS DEVELOPMENTS L.P. 

(“LANDLORD”) 

AND 
 BELLICUM
PHARMACEUTICALS, INC. 
 (“TENANT”) 

June 1, 2012 

 TABLE OF CONTENTS 
  

							
	 	  	 	  	Page	 
		
	 WITNESSETH:
	  	 	1	  
	 SEC. 1
	  	LEASED PREMISES	  	 	1	  
	 SEC. 2
	  	TERM:	  	 	3	  
	 SEC. 3
	  	USE:	  	 	3	  
	 SEC. 4
	  	SECURITY DEPOSIT:	  	 	3	  
	 SEC. 5
	  	BASE RENT:	  	 	4	  
	 SEC. 6
	  	ADDITIONAL RENT:	  	 	4	  
	 SEC. 7
	  	SERVICES AND UTILITIES:	  	 	10	  
	 SEC. 8
	  	MAINTENANCE, REPAIRS AND USE:	  	 	12	  
	 SEC. 9
	  	QUIET ENJOYMENT; RIGHTS RESERVED:	  	 	13	  
	 SEC. 10
	  	ALTERATIONS:	  	 	14	  
	 SEC. 11
	  	FURNITURE, FIXTURES AND PERSONAL PROPERTY:	  	 	15	  
	 SEC. 12
	  	SUBLETTING AND ASSIGNMENT:	  	 	16	  
	 SEC. 13
	  	FIRE AND OTHER CASUALTY:	  	 	18	  
	 SEC. 14
	  	CONDEMNATION:	  	 	18	  
	 SEC. 15
	  	DEFAULT BY TENANT:	  	 	19	  
	 SEC. 16
	  	REMEDIES OF LANDLORD:	  	 	20	  
	 SEC. 17
	  	LIEN FOR RENT:	  	 	22	  
	 SEC. 18
	  	NON-WAIVER:	  	 	22	  
	 SEC. 19
	  	LAWS AND REGULATIONS; RULES AND REGULATIONS:	  	 	22	  
	 SEC. 20
	  	ASSIGNMENT BY LANDLORD; LIMITATION OF LANDLORD’S LIABILITY:	  	 	22	  
	 SEC. 21
	  	SEVERABILITY:	  	 	22	  
	 SEC. 22
	  	SIGNS:	  	 	22	  
	 SEC. 23
	  	SUCCESSORS AND ASSIGNS:	  	 	23	  
	 SEC. 24
	  	SUBORDINATION:	  	 	23	  
	 SEC. 25
	  	TAX PROTEST:	  	 	24	  
	 SEC. 26
	  	HOLDING OVER:	  	 	24	  
	 SEC. 27
	  	INDEPENDENT OBLIGATION TO PAY RENT:	  	 	24	  
	 SEC. 28
	  	INDEMNITY; RELEASE AND WAIVER:	  	 	24	  
	 SEC. 29
	  	INSURANCE:	  	 	25	  
	 SEC. 30
	  	ENTIRE AGREEMENT:	  	 	25	  
	 SEC. 31
	  	NOTICES:	  	 	26	  
	 SEC. 32
	  	COMMENCEMENT DATE:	  	 	27	  
	 SEC. 33
	  	INTENTIONALLY DELETED:	  	 	27	  
	 SEC. 34
	  	BROKERS:	  	 	27	  
	 SEC. 35
	  	ESTOPPEL CERTIFICATES:	  	 	27	  
	 SEC. 36
	  	NAME CHANGE:	  	 	27	  
	 SEC. 37
	  	BANKRUPTCY:	  	 	27	  
	 SEC. 38
	  	TELECOMMUNICATIONS PROVIDERS:	  	 	28	  
	 SEC. 39
	  	HAZARDOUS SUBSTANCES:	  	 	28	  

  
 i 

							
	 SEC. 40
	  	NO MONEY DAMAGES FOR FAILURE TO CONSENT; WAIVER OF CERTAIN DAMAGES:	  	 	29	  
	 SEC. 41
	  	ACKNOWLEDGMENT OF NON-APPLICABILITY OF DTPA:	  	 	29	  
	 SEC. 42
	  	ATTORNEYS’ FEES:	  	 	29	  
	 SEC. 43
	  	AUTHORITY OF TENANT:	  	 	29	  
	 SEC. 44
	  	INABILITY TO PERFORM:	  	 	30	  
	 SEC. 45
	  	JOINT AND SEVERAL TENANCY:	  	 	30	  
	 SEC. 46
	  	EXECUTION OF THIS LEASE AGREEMENT:	  	 	30	  
	 SEC. 47
	  	WAIVER OF TRIAL BY JURY; COUNTERCLAIM:	  	 	30	  
	 SEC. 48
	  	CALCULATION OF TIME PERIODS:	  	 	30	  
	 SEC. 49
	  	ANTI-TERRORISM LAWS:	  	 	30	  
	 SEC. 50
	  	RENEWAL OPTIONS:	  	 	31	  
	 SEC. 51
	  	RIGHT OF FIRST REFUSAL:	  	 	31	  
	 SEC. 52
	  	PREFERENTIAL RIGHT TO LEASE:	  	 	33	  
	 SEC. 53
	  	CHASE SPACE:	  	 	34	  
	 SEC. 54
	  	BACK-UP GENERATOR:	  	 	34	  
	 SEC. 55
	  	FINANCIAL STATEMENTS:	  	 	35	  
	 SEC. 56
	  	LANDLORD DEFAULT:	  	 	35	  
	 SEC. 57
	  	EXHIBITS:	  	 	35	  

 EXHIBITS: 
  

	
	 EXHIBIT A - FLOOR PLAN OF THE LEASED PREMISES

	 EXHIBIT A-1 - FLOOR PLAN OF THE HOLD SPACE

	 EXHIBIT B - LEGAL DESCRIPTION OF THE LAND

	 EXHIBIT C - PARKING AGREEMENT

	 EXHIBIT D - RULES AND REGULATIONS

	 EXHIBIT E - ACCEPTANCE OF PREMISES MEMORANDUM

	 EXHIBIT F - TENANT’S ESTOPPEL CERTIFICAE

	 EXHIBIT G - LEASEHOLD IMPROVEMENTS

	 EXHIBIT H - AIR CONDITIONING AND HEATING SERVICES

	 EXHIBIT I - INSURANCE REQUIREMENTS

	 EXHIBIT J - PREVIOUSLY GRANTED ED EXCLUSIVE USES

	 EXHIBIT K - MODIFIED BOMA STANDARD

	 EXHIBIT L - LIST OF PREVIOUSLY GRANTED RENEWAL OPTIONS, EXPANSION OPTIONS, RIGHTS OF FIRST OFFER AND RIGHTS OF FIRST
REFUSAL

	 EXHIBIT M - FORM OF SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT

  
 ii 

 LEASE AGREEMENT 

Office Building 
 This
Lease Agreement (this “Lease Agreement”) is made and entered into as of the date set forth on the signature page between SHERIDAN HILLS DEVELOPMENTS L.P., a Texas limited partnership, hereinafter referred to as
“Landlord”, and BELLICUM PHARMACEUTICALS, INC., a Delaware corporation, hereinafter referred to as “Tenant”: 

WITNESSETH: 
 SEC. 1 LEASED PREMISES In
consideration of the mutual covenants as set forth herein, Landlord and Tenant hereby agree as follows: 
 A. Landlord hereby leases to
Tenant and Tenant hereby leases from Landlord for the rental and on the terms and conditions hereinafter set forth approximately 10,768 square feet of Net Rentable Area on the eighth
(8th) floor as indicated on the floor plan attached hereto as Exhibit A and made a part hereof for all purposes and known as Suite 850 (the “Leased Premises”)
in the medical office building located at 2130 West Holcombe Boulevard, Houston, Harris County, Texas 77030 (the “Building”) and situated on that certain tract or parcel of land more particularly described by metes and bounds on
Exhibit B attached hereto and made a part hereof for all purposes (the “Land”). Subject to Section 9.B below, Landlord hereby grants Tenant, its employees, invitees and other visitors, a nonexclusive license for
the Term of this Lease Agreement and all extensions and renewals thereof to use, for the purpose of ingress and egress to the Building and the Leased Premises, and in accordance with Section 19 below, the Common Areas (as hereinafter defined)
twenty-four hours a day, seven days a week (subject to temporary closures as necessary for repairs, maintenance or emergencies). Facilities and areas of the Building that are intended and designated by Landlord from time to time for the common,
general and non-exclusive use of all tenants of the Building, which include, without limitation, the Garage (as defined on Exhibit C), are called “Common Areas,” subject to the provisions of this Lease Agreement. Landlord has
the exclusive control over and right to manage the Common Areas. In addition, Landlord shall have the exclusive use and control over all other areas of the Building not designated as Common Areas nor leased exclusively to tenants of the Building,
which include, but are not limited to, all risers, horizontal and vertical shafts and telephone closets in the Building. 
 B. The term
“Net Rentable Area” shall mean the net rentable area measured according to standards based on but modified from those published by the Building Owners and Managers Association (BOMA) International, Publication ANSI/BOMA Z 65.1-2010,
both as may be amended or replaced from time to time (the “Modified BOMA Standard”). A copy of the current Modified BOMA Standard is attached hereto as Exhibit K and made a part hereof for all purposes. Within
thirty (30) days following the Commencement Date (the “NRA Notice Period”), if Landlord determines that the Net Rentable Area of the Leased Premises differs from that referenced in Section 1.A above, Landlord may
deliver a written notice to Tenant (the “NRA Notice”) specifying Landlord’s determination of the Net Rentable Area of the Leased Premises. If the Landlord does not deliver the NRA Notice during the NRA Notice Period, the
Net Rentable Area of the Leased Premises specified in Section 1.A above shall be deemed to be correct for all purposes under this Lease Agreement. If Landlord delivers the NRA Notice to Tenant within the NRA Notice Period, Tenant shall have the
next thirty (30) days (the “Response Period”) in which to have its architect verify the Net Rentable Area of the Leased Premises specified in the NRA Notice and notify Landlord in writing if Tenant disagrees with such
determination (the “NRA Response”). Tenant’s NRA Response must specify in detail the basis for Tenant’s disagreement with Landlord’s determination of the Net Rentable Area of the Leased Premises. Should Tenant fail to
deliver the NRA Response during the Response Period, the Net Rentable Area of the Leased Premises specified in the NRA Notice shall be deemed to be correct for all purposes under this Lease Agreement. If Tenant timely sends the NRA Response to
Landlord during the Response Period and Landlord’s architect and Tenant’s architect are unable to agree on the Net Rentable Area of the Leased Premises within the next thirty (30) days [such thirty (30) day period commencing
on the date of the NRA Response (the “Negotiation Period”)], the Net Rentable Area of the Leased Premises shall be determined by an independent third-party architect mutually selected by Landlord and Tenant in good faith within five
(5) business days of the expiration of the Negotiation Period (the fees of such architect being shared equally by Landlord and Tenant). Such independent third-party architect shall make the final and conclusive determination of the Net
Rentable Area of the Leased Premises within thirty (30) days of his/her appointment. All measurements of the 

  
 1 

 
Leased Premises and the Building shall be made in accordance with the Modified BOMA Standard. If the Building is ever demolished, altered, remodeled, renovated, expanded or otherwise changed
in such a manner as to alter the amount of space contained therein, then the Net Rentable Area of the Building shall be adjusted and recalculated by using the Modified BOMA Standard. 

C. Landlord also leases to Tenant certain parking spaces on the terms and conditions set forth in Exhibit C attached hereto
and made a part hereof for all purposes. 
 D. The Leased Premises shall be delivered to Tenant and Tenant shall accept same, in its current
“AS IS, WHERE IS” condition subject to the construction of leasehold improvements set forth and described on Exhibit G attached hereto and made a part hereof for all purposes and the completion of any incomplete
or corrective items specified in a “punch list” approved by Landlord and Tenant pursuant to Exhibit G and latent defects, to the extent Tenant notifies Landlord thereof in writing within the first six (6) months
following the Commencement Date. Tenant acknowledges that no representations as to the repair of the Leased Premises or the Building, nor promises to alter, remodel or improve the Leased Premises or the Building, have been made by Landlord, except
as are expressly set forth in this Lease Agreement. 
 E. Tenant shall have the option (the “Hold Option”) to lease the
space located on the eighth (8th) floor of the Building containing approximately 3,642 square feet of Net Rentable Area, as indicated on the floor plan attached hereto as Exhibit A-1 and made a part hereof for all purposes,
or any portion thereof that is contiguous to the Leased Premises (the “Hold Space”). In the event that Tenant desires to exercise the Hold Option, Tenant must deliver written notice (the “Hold Option Exercise
Notice”) to Landlord in respect of the applicable portion of the Hold Space which the Tenant elects to lease, by 5:00 p.m., Central Time, on or before the two hundred seventieth (270th) day following the Commencement Date (the
“Hold Option Exercise Date”). In the event Tenant fails to deliver such written notice to Landlord on or before the Hold Option Exercise Date in respect of all of the Hold Space, the Hold Option will terminate and be of no further
force and effect with regard to the portion of the Hold Space not leased. If Tenant shall have elected (in accordance with and subject to the provisions of this Section 1.E) to exercise the Hold Option, the Hold Space shall be deemed to be part
of the Leased Premises for all purposes under this Lease Agreement, and the Hold Space shall be delivered to Tenant ten (10) days after Landlord’s receipt of the Hold Option Exercise Notice, hereinafter referred to as the “Hold Space
Delivery Date”, with the commencement date with respect to the applicable portion of the Hold Space to be the earlier to occur of (i) Tenant’s beneficial occupancy of such space for the purpose of conducting its business therein, or
(ii) sixty (60) days after the Hold Space Delivery Date for the purposes of Tenant undertaking leasehold improvement work therein (such earlier date, the “Hold Space Commencement Date”). The lease of the Hold Space shall
be upon, and subject to, all of the terms, covenants and conditions provided in this Lease Agreement with respect to the Leased Premises; provided, however, that Base Rent for the Hold Space shall be dated for purposes of rent increases per the
schedule set forth in Section 5.A. from the Commencement Date applicable to the original Leased Premises, not from the Hold Space Commencement Date (provided, however, Base Rent for any Hold Space shall not accrue until the Hold Space
Commencement Date for such space); and Tenant will be only be provided with a leasehold improvement allowance for such Hold Space equal to the product of (x) $45.00 per square foot of Net Rentable Area in the Hold Space and (y) a quotient,
the numerator of which is the number of months in the initial Term remaining from the Hold Space Commencement Date and the denominator of which is the number of months in the initial Term. This Lease Agreement shall be deemed to have been
automatically amended in accordance with this Section 1.E as of the date of the Hold Option Exercise Notice, and Tenant and Landlord shall thereafter promptly (but in no event longer than fifteen (15) days after Landlord’s submission
of the amendment to Tenant) execute and deliver an appropriate amendment of this Lease Agreement to evidence the foregoing. Notwithstanding any provision herein to the contrary, Tenant shall not have the right to lease the Hold Space pursuant to
this Section 1.E if, at the time Tenant exercises such Hold Option or on the applicable Hold Space Commencement Date, an Event of Default (as hereinafter defined) then exists under this Lease Agreement. Any termination of this Lease Agreement
shall also terminate the Hold Option. Tenant shall not have the right to assign the Hold Option to any subtenant of the Leased Premises or assignee of this Lease Agreement (other than a Permitted Transferee [hereinafter defined]), nor may any such
subtenant or assignee (other than a Permitted Transferee) exercise such Hold Option unless in connection with an assignment of Tenant’s entire interest in this Lease Agreement or a sublease of the entire Leased Premises. 

  
 2 

 SEC. 2 TERM: 

A. The term of this Lease Agreement (the “Term”) shall commence on the Leasehold Improvements Completion Date (as defined in
Exhibit G) which is anticipated to be November 1, 2012 (the “Estimated Leased Premises Delivery Date”), less the total number of days of Tenant Delay (as defined on Exhibit G) (such date being herein
referred to as the “Commencement Date”) and, unless sooner terminated or renewed and extended in accordance with the terms and conditions set forth herein, shall expire at 11:59 p.m. on the day preceding the fifth
(5th) anniversary of the Commencement Date (the “Expiration Date”). Notwithstanding any provision herein to the contrary, the Commencement Date shall not be prior to November 1, 2012. 

B. This Lease Agreement shall be effective as of the Effective Date (as hereinafter defined). Landlord hereby consents to Tenant and its
agents, employees or contractors entering the Leased Premises prior to the Commencement Date for purposes of undertaking alterations, additions and improvements therein, including, but not limited to, telephone, and data cabling and installation of
furniture systems, which entry shall be subject to the terms and conditions of this Lease Agreement, except that the Rent (as hereinafter defined) shall not commence to accrue as a result of such entry until the date specified in Section 5
below. 
 SEC. 3 USE: The Leased Premises shall be used and occupied by Tenant solely as (i) general office purposes and other uses customarily
associated therewith, (ii) a research laboratory up to and including Biosafety Level 2 and for no other purposes. In addition to the foregoing uses, in the event that Tenant exercises the Hold Option, Tenant’s Right of First Refusal set
forth in Section 51 below, or Tenant’s Preferential Right to Lease set forth in Section 52 below, Tenant shall be permitted to operate a vivarium (limited to mice only) in the Hold Space or such space obtained through Tenant’s
exercise of Tenant’s Right of First Refusal or Tenant’s Preferential Right to Lease. The Leased Premises shall not be used for any purpose which would tend to lower the first-class character of the Building, violate any other tenants’
exclusive use, if any, previously granted by Landlord, which exclusive use is identified in Exhibit J attached hereto and made a part hereof for all purposes, create unreasonable elevator loads or otherwise interfere with standard
Building operations. Tenant agrees specifically that no food, soft drink or other vending machine will be installed within the Leased Premises without the prior written consent of Landlord, which consent shall not be unreasonably withheld,
conditioned or delayed. Under no circumstances shall any abortions be performed in the Leased Premises (but the foregoing does not prohibit routine gynecological procedures). 

SEC. 4 SECURITY DEPOSIT: $27,144.33 payable on the Effective Date. Upon the occurrence of any Event of Default, Landlord may, from time to time,
without prejudice to any other remedy, use the security deposit paid to Landlord by Tenant as herein provided to the extent necessary to make good any arrears of Rent (as hereinafter defined) and any other damage, injury, expense or liability caused
to Landlord by such Event of Default. Following any such application of the security deposit, Tenant shall pay to Landlord within ten (10) days of demand the amount so applied in order to restore the security deposit to the amount thereof
existing prior to such application. Any remaining balance of the security deposit shall be returned by Landlord to Tenant within sixty (60) days after the termination of this Lease Agreement and after Tenant provides written notice to Landlord
of Tenant’s forwarding address; provided, however, Landlord shall have the right to retain and expend such remaining balance (a) to reimburse Landlord for any and all rentals or other sums due hereunder that have not been paid in full by
Tenant and/or (b) for cleaning and repairing the Leased Premises if Tenant shall fail to deliver same at the termination of this Lease Agreement in a neat and clean condition and in as good a condition as existed at the date of possession of
same by Tenant, ordinary wear and tear and casualty loss only excepted. Tenant shall not be entitled to any interest on the security deposit. Such security deposit shall not be considered an advance payment of rental or a measure of Landlord’s
damages in case of an Event of Default by Tenant. 

  
 3 

 SEC. 5 BASE RENT: 

A. As part of the consideration for the execution of this Lease Agreement, Tenant covenants and agrees and promises to pay Landlord base rent
according to the following schedule (the “Base Rent”): 
  

													
	Months Following the
Commencement Date	 	Annual Base Rent Rate Per
Square Foot of Net Rentable Area	 	 	Annual Base Rent	 	 	Monthly
Payment	 
	1-12	 	$	28.25	  	 	$	304,196.00	  	 	$	25,349.67	  
	13-24	 	$	28.75	  	 	$	309,580.00	  	 	$	25,798.33	  
	25-36	 	$	29.25	  	 	$	314,964.00	  	 	$	26,247.00	  
	37-48	 	$	29.75	  	 	$	320,348.00	  	 	$	26,695.66	  
	49-60	 	$	30.25	  	 	$	325,732.00	  	 	$	27,144.33	  

 The Base Rent shall be payable to Landlord at the address of the Landlord’s property manager set forth in
Section 31 below (or such other address as may be designated by Landlord in writing from time to time) in monthly installments in legal tender of the United States of America, in advance, without demand, set-off or counterclaim except as herein
expressly provided, on or before the first day of each calendar month during the Term hereof; provided, however, the first monthly payment of Base Rent shall be made on the Effective Date. If the Term of this Lease Agreement as described above
commences on other than the first day of a calendar month or terminates on other than the last day of a calendar month, then the installments of Base Rent for such month or months shall be prorated and the installment or installments so prorated
shall be paid in advance. The payment for such prorated month shall be calculated by multiplying the monthly installment by a fraction, the numerator of which shall be the number of days of the Term occurring during said commencement or termination
month, as the case may be, and the denominator of which shall be the total number of days occurring in said commencement or termination month. 

B. In addition to the foregoing Base Rent and the Additional Rent to be paid by Tenant pursuant to Section 6 below, Tenant agrees to pay
to Landlord as additional rent all charges for any services, goods or materials furnished by Landlord at Tenant’s request which are not required to be furnished by Landlord under this Lease Agreement, as well as other sums payable by Tenant
hereunder, within ten (10) days after Landlord renders a statement therefor to Tenant. All Rent (as hereinafter defined) shall bear interest from the date due until paid at the greater of (i) two percent (2%) above the “prime
rate” per annum of the JPMorgan Chase Bank, a New York banking corporation or its successor or such other “money center” bank as Landlord and Tenant may agree from time to time (“Chase”) in effect on said due date (or
if the “prime rate” be discontinued, the base reference rate then being used by Chase to define the rate of interest charged to commercial borrowers) or (ii) ten percent (10%) per annum; provided, however, in no event shall the
rate of interest hereunder exceed the maximum non-usurious rate of interest (hereinafter called the “Maximum Rate”) permitted by the applicable laws of the State of Texas or the United States of America, and to the extent that the
Maximum Rate is determined by reference to the laws of the State of Texas, the Maximum Rate shall be the weekly ceiling (as defined and described in Chapter 303 of the Texas Finance Code, as amended) at the applicable time in effect. 

C. If the Net Rentable Area of the Leased Premises is modified for any reason, the provisions of this Lease Agreement which are contingent
upon the size of the Leased Premises (including without limitation, Base Rental, Additional Rent, Tenant’s pro rata share, the Improvement Allowance and number of reserved Parking Spaces and number of unreserved Parking Spaces) shall be
automatically adjusted to reflect the modification of the Net Rentable Area of the Leased Premises, effective as of the date of the determination made in accordance with Section 1.B above. If the Net Rentable Area of the Building is modified
for any reason, the provisions of this Lease Agreement which are contingent upon the size of the Building (including, without limitation, Tenant’s pro rata share) shall automatically be adjusted to reflect the modification of the Net Rentable
Area of the Building, effective as of the date of the determination made in accordance with Section 1.B above. The parties shall memorialize all such adjustments in an amendment to this Lease Agreement as soon as reasonably possible thereafter.

 SEC. 6 ADDITIONAL RENT: 
 A. As part
of the consideration for the execution of this Lease Agreement, and in addition to the Base Rent specified above, Tenant covenants and agrees to pay, for each calendar year during the Term, as additional rent (the “Additional
Rent”), Tenant’s pro rata share of the Operating Expenses (as hereinafter defined) for that year. Tenant’s pro rata share shall be a fraction, the numerator of which is the Net Rentable Area in the Leased Premises and the
denominator of which is the Net Rentable Area in the Building. 
 B. All Operating Expenses shall be determined in accordance with generally
accepted accounting principles, consistently applied and shall be computed on the accrual basis. The term “Operating Expenses” as 

  
 4 

 
used herein shall mean all expenses, costs and disbursements in connection with the ownership, operation, management, maintenance and repair of the Building, the Land, related pedestrian
walkways, landscaping, fountains, roadways and parking facilities (including the Garage [as defined on Exhibit C]), and such additional facilities to service any of the foregoing in subsequent years as may be necessary or desirable in
Landlord’s reasonable discretion (the Building, the Land and said additional facilities being hereinafter sometimes referred to as the “Complex”), including but not limited to the following: 

 

	 	(1)	Wages and salaries of all employees engaged in the operation, security, cleaning and maintenance of the Complex, including customary taxes, insurance and benefits relating thereto, allocated based upon the time such
employees are engaged directly in providing such services, but not above the level of property manager. 

  

	 	(2)	All supplies, tools, equipment and materials used in operation and maintenance of the Complex. 

  

	 	(3)	Cost of all utilities for the Complex, including but not limited to the costs of water, electricity, gas, heating, lighting, air conditioning and ventilation; provided, however, in the event that Landlord elects to
meter or sub-meter any or all of the aforementioned utilities in accordance with Section 7.E hereof, Operating Expenses shall not include the cost of such metered or sub-metered utilities provided to the Leased Premises or the leased premises
of the other tenants in the Complex. 

  

	 	(4)	Cost of all janitorial service, maintenance and service agreements for the Complex and the equipment therein, including alarm service, security service, window cleaning, janitorial service, trash removal and elevator
maintenance. 

  

	 	(5)	Cost of all insurance relating to the Complex which Landlord may elect to obtain, including but not limited to casualty and liability insurance applicable to the Complex and Landlord’s personal property used in
connection therewith; the amount of the commercially reasonable deductible paid by Landlord or deducted from any insurance proceeds paid to Landlord shall also constitute an Operating Expense. 

 

	 	(6)	 Accounting costs and audit fees attributable to Landlord’s ownership of the Complex, including without limitation in connection with tax returns.
All taxes and assessments and other governmental charges (whether federal, state, county or municipal and whether they be by taxing districts or authorities presently taxing the Leased Premises or by others subsequently created or otherwise) and any
other taxes and improvement assessments attributable to the Complex, or its operation or the revenues or rents received therefrom (whether directly or indirectly through the use of a franchise, margin or other similar tax and whether or not such
taxes allow for the deduction of expenses in calculating the base amount on which the tax is levied) but excluding, however, federal and state taxes on income (collectively, “Taxes”); provided, however, that if at any time during
the Term, new taxes, assessments, levies, impositions or charges are imposed on the rents received from the Complex or the rents reserved herein or any part thereof (whether directly or indirectly through the use of a franchise, margin or other
similar tax), or the present method of taxation or assessment shall be so changed that the whole or any part of the taxes, assessments, levies, impositions or charges now levied, assessed or imposed on real estate and the improvements thereof shall
be discontinued and as a substitute therefor, or in lieu of an increase to the tax rate thereof, taxes, assessments, levies, impositions or charges shall be levied, assessed and/or imposed wholly or partially as a capital levy or otherwise on the
rents received from the Complex or the rents reserved herein or any part thereof (whether directly or indirectly through the use of a franchise, margin or similar tax and whether or not such taxes allow for the deduction of expenses in calculating
the base amount on which the tax is levied), then such substitute or additional taxes, assessments, levies, impositions or charges, to the extent so levied, assessed or imposed, shall be deemed to be included within Taxes to the extent that such

  
 5 

	 	
substitute or additional tax would be payable if the Complex were the only property of the Landlord subject to such tax. It is agreed that Tenant will also be responsible for ad valorem taxes on
its personal property and on the value of leasehold improvements to the extent that the same exceed standard building allowance, provided, however, that such amount(s) is(are) expressly set out in the tax statements from the taxing authorities, or
are reasonably determinable from tax statements that pertain specifically to the Leased Premises, even if no reference is made in such statements to “standard building allowance” or similar concepts. 

 

	 	(7)	Amortization of the cost of installation of capital investment items that have been (whether before or during the Term) or are hereafter installed for the purpose of reducing Operating Expenses or which may be required
by any laws, ordinances, orders, rules, regulations and requirements which are amended, become effective or are interpreted differently after the Commencement Date which impose any duty with respect to or otherwise relate to the use, condition,
occupancy, maintenance or alteration of the Complex. All such costs which relate to the installation of such capital investment items shall be amortized over the reasonable life of the capital investment item, with the reasonable life and
amortization schedule being determined in accordance with generally accepted accounting principles as reasonably determined by Landlord. 

  

	 	(8)	The property management fees incurred by Landlord, in no event to exceed four percent (4%) of the gross revenues (but expressly excluding parking revenues) received by Landlord on the Complex. 

 

	 	(9)	Cost of repairs and general maintenance (excluding repairs and general maintenance paid by proceeds of insurance or by Tenant or other third parties) for the Complex. 

 

	 	(10)	The reasonable rental value of the Building management office (which shall not exceed 3,000 square feet of Net Rentable Area). 

  

	 	(11)	All costs incurred by Landlord for the purpose of reducing Operating Expenses, including, without limitation, the cost of all tax protests (subject to the provisions set forth in Section 6.B(7) above.

 C. Notwithstanding anything contained in this Lease Agreement to the contrary, the following shall not be included in or
considered as Operating Expenses: 
  

	 	(1)	Except as set forth in Section 6.B(7) above, expenditures classified as capital expenditures, including without limitation, capital improvements, capital repairs, capital equipment and capital tools, under
generally accepted accounting principles consistently applied, including rental payments with respect to capital items, or any non-cash charges such as depreciation or amortization. All costs incurred for the acquisition and renovation, construction
and improving of the Complex and Garage, and readying same for occupancy and use, including without limitation tap fees or other one-time utility charges and initial installation of landscaping improvements, light fixtures and other items, even if
the replacement thereof is permitted to be included in Operating Expenses shall be excluded from Operating Expenses. 

  

	 	(2)	Advertising, promotional expenses, leasing commissions, attorneys fees, costs and disbursements and other expenses incurred in connection with the leasing of the Complex or negotiations or disputes relating to leasing
and lease interpretations with tenants or prospective tenants or other occupants of the Complex. Personnel costs of persons on-site and off-site to the extent same are engaged in leasing activities shall be excluded from Operating Expenses. Gifts,
meals and entertainment expenses incurred with tenants, tenant prospects and brokers shall be excluded from Operating Expenses. 

  
 6 

	 	(3)	The cost of repairs or other work occasioned by any casualty which is covered by insurance or coverable by standard all risk property insurance available in Texas, or by the exercise of the right of eminent domain or
otherwise reimbursed to Landlord from another source, net of deductibles carried by Landlord, and reasonable out-of-pocket cost of adjustment. 

  

	 	(4)	Landlord’s cost of HVAC, electricity, water, janitorial and other services or benefits sold or provided to tenants in the Complex and for which Landlord is entitled to be reimbursed by such tenants as a separate
additional charge or rental over and above the base rent or additional rent payments payable under the lease agreement with such tenant. The cost of providing HVAC services to other tenants at times or in quantities in excess of that made available
to Tenant without special charge under this Lease Agreement, and the cost of providing electricity, water, janitorial or other services to other tenants in quantities or at specifications in excess of that made available to Tenant without special
charge under this Lease Agreement, shall be excluded from Operating Expenses regardless of whether Landlord offers such services to other tenants without special charge under the terms of such other tenants’ leases. 

 

	 	(5)	All costs (including permit, license and inspection fees), however paid, in demolishing, removing, completing, fixturing, furnishing, renovating, decorating or otherwise altering or improving space for tenants or other
occupants of the Complex or for vacant space, or for any management office, including space planning, interior design and engineering work. 

  

	 	(6)	Except as set forth in Section 6.B(7) above, all costs incurred by Landlord in connection with the design or construction of the Complex or any equipment therein and related facilities, the correction of defects in
design, construction or in the discharge of Landlord’s obligations under Exhibit G attached to this Lease Agreement. 

  

	 	(7)	Except as set forth in Section 6.B(7) above, all costs of removing, remediating, encapsulating and/or monitoring any hazardous waste, substance or material, including, without limitation, asbestos containing
materials, but excluding automotive fuels discharged in driving and parking areas of the Complex. Notwithstanding Section 6.B(7) above, all operating and capital costs required by or incurred in connection with (i) the installation of any
capital improvement required by any law, ordinance or regulation enacted before the Effective Date, including, without limitation, the Americans with Disabilities Act, the Texas Architectural Barriers Act, the Houston Life Safety Ordinance, but
excluding any changes in interpretations, enforcement or ruling thereon after the Effective Date, (ii) the existence of chlorofluorocarbons (freon) in the Complex heating ventilation and air conditioning system or variable air volume system, or
(iii) any future asbestos abatement of the Complex shall be excluded from Operating Expenses. 

  

	 	(8)	All costs, including without limitation fines, penalties and legal fees, incurred or imposed in connection with any legal violation by Landlord or the property manager or any breach or default by Landlord under any loan
or mortgage instrument or any lease or license agreement. All costs, including without limitation interest, late charges, penalties and legal fees, incurred in connection with any late payment by Landlord. 

 

	 	(9)	Except as otherwise provided in Section 6.B(6) above, federal and state taxes on income and inheritance, estate and gift taxes of Landlord, the property manager and their respective affiliates, and all taxes
imposed on or calculated on the basis of any mortgage encumbering the Complex or Garage or in connection with any transfer of ownership of the Complex or Garage or beneficial interests therein. 

 

	 	(10)	 Ad valorem taxes attributable to the leasehold improvements of Tenant and the other tenants of the Complex in excess of Complex standard but only to
the extent (a) Landlord 

  
 7 

	 	
is reimbursed directly by such other tenants for any ad valorem taxes attributable to the above Building standard leasehold improvements of such other tenants or (b) a separate allocation is
made by the applicable taxing authority. 

  

	 	(11)	All payments to any affiliate of Landlord for services in excess of the costs of arms-length, third-party providers for services of comparable quality and scope. 

 

	 	(12)	Compensation paid to clerks, attendants or other persons in commercial concessions operated by Landlord or the property manager. 

  

	 	(13)	All costs incurred in connection with the operation, maintenance or repair of any antennae or satellite facilities, unless such services are being provided to all tenants of the Complex, including Tenant.

  

	 	(14)	Except as otherwise provided in Section 6.B(6) above, other costs (including consulting fees and related disbursements) incurred in connection with Landlord’s ownership of the Complex to the extent not
directly related to the operation, maintenance and repair thereof, including without limitation, costs of any disputes between Landlord and its employees or the property manager and costs of selling, syndicating, financing, mortgaging or
hypothecating any of the Landlord’s interest in the Complex and/or common areas, costs of defending Landlord’s title or interest in and to said property. 

 

	 	(15)	All contributions to charitable organizations. 

  

	 	(16)	All contributions to reserves for Operating Expenses. 

  

	 	(17)	Except as otherwise provided in Section 6.B(6) above, any special assessments of taxes from any city, county, state or federal governmental agency, including, but not limited to, such items as parking income taxes.

  

	 	(18)	Costs of repair or replacement for any item to the extent that Landlord is reimbursed for same pursuant to a warranty. 

  

	 	(19)	Costs which Landlord is reimbursed by its insurance carrier or by any tenant’s insurance carrier or by any other entity. 

  

	 	(20)	Any fines, costs, penalties or interest resulting from the negligence or willful misconduct of the Landlord or its agents, contractors or employees. 

 

	 	(21)	Any bad debt loss, rent loss or reserves for bad debt or rent loss. 

  

	 	(22)	All payments of principal, interest or other charges of any kind incurred in connection with any indebtedness secured by the Complex, and any payments under any ground lease or other underlying lease; provided that if
Landlord makes payment of ad valorem taxes to its lender, rather than to taxing authorities, then payment to the lender shall not be included in Operating Expenses, but payments by the lender to taxing authorities shall be considered payments by
Landlord, to be included in Operating Expenses to the extent otherwise provided for herein. 

  

	 	(23)	The cost of any additional casualty insurance premium for the Complex in excess of the standard rate payable by Landlord, which additional cost is attributable to: (a) the tenancy of a particular tenant or tenants
in the Complex other than Tenant or (b) the use of any part of the Complex by Landlord other than for purposes of providing general services to the Complex. 

  

	 	(24)	Accounting costs and audit fees attributable to Landlords ownership (as opposed to the operation) of the Complex, including in connection with Landlord’s income tax returns. 

  
 8 

 D. If the Term of this Lease Agreement commences or terminates on other than the first day of a
calendar year, Tenant’s Additional Rent shall be prorated for such commencement or termination year, as the case may be, by multiplying each by a fraction, the numerator of which shall be the number of days of the Term during the commencement
or termination year, as the case may be, and the denominator of which shall be 365, and the calculation described in Section 6.F below shall be made as soon as reasonably possible after the termination of this Lease Agreement, Landlord and
Tenant hereby agreeing that the provisions relating to said calculation shall survive the termination of this Lease Agreement. 
 E. On or
about January 1 of each calendar year during the Term, Landlord shall endeavor to deliver to Tenant Landlord’s good faith estimate of Tenant’s Additional Rent (the “Estimated Additional Rent”) for such year. The
Estimated Additional Rent shall be paid in equal installments in advance on the first day of each month. If Landlord does not deliver an estimate to Tenant for any year by January 1 of that year, Tenant shall continue to pay Estimated
Additional Rent based on the prior year’s estimate until Landlord’s estimate is delivered to Tenant. From time to time during any calendar year, but in no event more than twice in any calendar year, Landlord may revise its estimate of the
Additional Rent for that year based on either actual or reasonably anticipated increases in Operating Expenses, and the monthly installments of Estimated Additional Rent shall be appropriately adjusted for the remainder of that year in accordance
with the revised estimate so that by the end of the year, the total payments of Estimated Additional Rent paid by Tenant shall equal the amount of the revised estimate. 

F. Within one hundred fifty (150) days after the end of each calendar year during the Term, or as soon as reasonably practicable
thereafter, Landlord shall provide Tenant a statement showing the Operating Expenses for said calendar year, prepared in accordance with generally accepted accounting practices, and a statement prepared by Landlord comparing Estimated Additional
Rent paid by Tenant with actual Additional Rent. If the Estimated Additional Rent paid by Tenant, if any, exceeds the actual Additional Rent for said calendar year, Landlord shall pay Tenant an amount equal to such excess at Landlord’s option,
by either giving a credit against rentals next due, if any, or by direct payment to Tenant within thirty (30) days of the date of such statement. If the actual Additional Rent exceeds Estimated Additional Rent for said calendar year, Tenant
shall pay the difference to Landlord within thirty (30) days of receipt of the statement. The provisions of this paragraph shall survive the expiration or termination of this Lease Agreement. Any amount due to the Landlord as shown on
Landlord’s statement described above, whether or not disputed by Tenant as provided herein shall be paid by Tenant when due as provided above, without prejudice to any subsequent written exception made pursuant to Section 6.I. The
Base Rent, Additional Rent and all other sums of money that become due and payable under this Lease Agreement shall collectively be referred to herein as “Rent”. 

G. Notwithstanding any other provision herein to the contrary, it is agreed that if less than one hundred percent (100%) of the Net
Rentable Area of the Building is occupied during any calendar year or if less than one hundred percent (100%) of the Net Rentable Area of the Building is being provided with Building standard services during any calendar year, an adjustment
shall be made in computing each component of the Operating Expenses for that year which varies with the rate of occupancy of the Building (such as, but not limited to, utilities, management fees and janitorial services) so that the total Operating
Expenses shall be computed for such year as though the Building had been one hundred percent (100%) occupied during such year and as though one hundred percent (100%) of the Building had been provided with Building standard services during
that year. 
 H. All Additional Rent shall be paid by Tenant to Landlord contemporaneously with the required payment of Base Rent on the
first day of each calendar month, monthly in advance, for each month of the Term, in lawful money of the United States at the address of the Landlord’s property manager specified in Section 31 below (or such other address as may be
designated by Landlord in writing from time to time). No payment by Tenant or receipt by Landlord of an amount less than the amount of Rent herein stipulated to be paid shall be deemed to be other than on account of the stipulated Rent, nor shall
any endorsement on any check or any letter accompanying such payment of Rent be deemed an accord and satisfaction, but Landlord may accept such payment without prejudice to his rights to collect the balance of such Rent. 

  
 9 

 I. Landlord shall maintain full and complete records of Operating Expenses and exclusions
therefrom in accordance with generally accepted accounting principles and good commercial practice and sufficient to enable Tenant to audit Operating Expenses to confirm that Operating Expenses are being charged in accordance with this Lease
Agreement. Not more than once per calendar year, and only on or before the sixtieth (60th) day following the date Landlord delivered the statement described in Section 6.F above to
Tenant setting out the adjustment, if any, to the Estimated Additional Rent (the Estimated Additional Rent, as adjusted by such statement, is hereinafter referred to as the “Adjusted Additional Rent”), Tenant shall have the right,
directly or through agents or contractors, to commence an inspection and audit of Landlord’s books and records pertaining to Operating Expenses and exclusions therefrom for the period covered by the statement only, upon reasonable advance
notice to and coordination with Landlord; provided, however, in no event will Landlord be obligated to permit any such inspection or audit to be performed by a consultant or firm that is compensated by Tenant on a contingent fee or percentage of
recovery basis. If Tenant fails to commence such audit on or before the sixtieth (60th) day following the date Landlord delivered the statement described in Section 6.F above to Tenant
or to complete such audit and deliver the auditor’s report to Landlord before the ninetieth (90th) day following the delivery of such statement, then Tenant shall conclusively be deemed
to have accepted the Adjusted Additional Rent specified in such statement and to have waived any right to contest such amount in the future. The cost of any such review or audit by Tenant shall be borne solely by Tenant. Notwithstanding the
foregoing, if following such audit it is conclusively determined that the Adjusted Additional Rent exceeds the actual Additional Rent by more than five percent (5%) for the calendar year in question, Landlord shall reimburse Tenant for all of
Tenant’s reasonable out of pocket costs and expenses incurred by Tenant in connection with such audit. If following such audit, it is conclusively determined that the Adjusted Additional Rent paid by Tenant exceeds the actual Additional Rent
for said calendar year, Landlord shall pay Tenant an amount equal to such excess at Landlord’s option, by either giving a credit against rentals next due, if any, or by direct payment to Tenant within thirty (30) days of the date of such
determination. If as a result of such audit, it is conclusively determined that the actual Additional Rent exceeds the Adjusted Additional Rent for said calendar year, Tenant shall pay to Landlord within thirty (30) days of the date of such
determination, the positive difference between the amount that the actual Additional Rent exceeds the Adjusted Additional Rent for said calendar year. 

J. Landlord and Tenant hereby each acknowledge and agree that they are knowledgeable and experienced in commercial transactions and
further hereby acknowledge and agree that the provisions of this Lease Agreement for determining Operating Expenses and other charges are commercially reasonable and valid even though such methods may not state precise mathematical formulae for
determining such Operating Expenses. ACCORDINGLY, TENANT HEREBY VOLUNTARILY AND KNOWINGLY WAIVES ALL RIGHTS AND BENEFITS TO WHICH TENANT MAY BE ENTITLED UNDER SECTION 93.012 OF THE TEXAS PROPERTY CODE, AS ENACTED BY HOUSE BILL 2186, 77TH LEGISLATURE, AS SUCH SECTION NOW EXISTS OR AS SAME MAY BE HEREAFTER AMENDED OR SUCCEEDED. 
 SEC.
7 SERVICES AND UTILITIES: 
 A. Provided no Event of Default has occurred and is continuing hereunder, and subject to the
provisions of Sections 7.B and 7.C below, Landlord shall furnish the following services and amenities (collectively, the “Required Services”) to Tenant (and its assignees and sublessees permitted hereunder) while occupying the
Leased Premises: 
  

	 	(1)	Domestic water at those points of supply provided for general use of the tenants of the Building; 

  

	 	(2)	Chilled water piping to the west mechanical room on the eighth (8th) floor of the Building for central heat, ventilation and air conditioning in season,
twenty-four (24) hours per day, seven (7) days per week, all as more particularly described on Exhibit H attached hereto and made a part hereof for all purposes; 

 

	 	(3)	Electric lighting service for all public areas and special service areas of the Building in the manner and to the extent deemed by Landlord to be in keeping with the standards of other comparable medical office
buildings in and in the vicinity of the Texas Medical Center area of Houston, Texas; 

  
 10 

	 	(4)	Janitor service on a five (5) day week basis, in the manner and to the extent deemed standard by Landlord during the periods and hours as such services are normally furnished to tenants in the Building and such
window-washing as may from time to time in Landlord’s judgment reasonably be required, all in keeping with the standards of other comparable medical office buildings in and in the vicinity of the Texas Medical Center area of Houston, Texas;

  

	 	(5)	On-site security personnel and equipment for the Building; provided, however, that Tenant agrees that Landlord shall not be responsible for the adequacy or effectiveness of such security provided that (i) Landlord
has exercised reasonable care in the selection of the security contractor and equipment, and (ii) the scope and extent of the security services contracted for by Landlord are in keeping with the standards of other comparable medical office
buildings in and in the vicinity of the Texas Medical Center area of Houston, Texas; 

  

	 	(6)	Electrical facilities to furnish 24 hours a day, seven days a week (i) power to operate typewriters, personal computers, calculating machines, photocopying machines and other equipment that operates on 120/208
volts (collectively, the “Low Power Equipment”); provided, however, total rated connected load by the Low Power Equipment shall not exceed an annual average of four (4) watts per square foot of Net Rentable Area of the Leased
Premises and (ii) power to operate Tenant’s lighting and Tenant’s equipment that operates on 277/480 volts (collectively, the “High Power Equipment”); provided, however, total rated connected load by the High Power
Equipment shall not exceed an annual average of two (2) watts per square foot of Net Rentable Area of the Leased Premises. In the event that the Tenant’s connected loads for low electrical consumption (120/208 volts) and high electrical
consumption (277/480 volts) are in excess of those loads stated above, as determined by an independent utility consultant, and Landlord agrees to provide such additional load capacities to Tenant (such determination to be made by Landlord in its
sole discretion), then Landlord may install and maintain, at Tenant’s expense, electrical submeters, wiring, risers, transformers, and electrical panels, and other items required by Landlord, in Landlord’s discretion, to accommodate
Tenant’s design loads and capacities that exceed those loads stated above, including, without limitation, the installation and maintenance thereof. 

  

	 	(7)	All Building standard fluorescent bulb replacement and all incandescent bulb replacement in the Common Areas of the Complex; and 

  

	 	(8)	Non-exclusive passenger elevator service to the Leased Premises twenty-four (24) hours per day and non-exclusive freight elevator service during normal business hours of the Building. 

B. The obligation of Landlord to provide the Required Services shall be subject to governmental regulation thereof (i.e., rationing,
temperature control, etc.) and any such regulation that impairs Landlord’s ability to provide the Required Services as herein stipulated shall not constitute an Event of Default hereunder but rather providing the applicable Required Services to
the extent allowed pursuant to such regulations shall be deemed to be full compliance with the obligations and agreements of Landlord hereunder. 

C. To the extent any of the Required Services require electricity, gas and water supplied by public utilities or others, Landlord’s
covenants hereunder shall only impose on Landlord the obligation to use its good faith efforts to cause the applicable public utilities or other providers to furnish the same. Failure by Landlord to furnish any of the Required Services to any
extent, or any cessation thereof, due to failure of any public utility or other provider to furnish service to the Building, or any other cause beyond the reasonable control of Landlord, shall not render Landlord liable in any respect for damages to
either person or property, nor be construed as an eviction of Tenant, nor work an abatement of Rent, nor relieve Tenant from fulfillment of any covenant or agreement hereof. As used herein, the phrase “cause beyond the reasonable control of
Landlord” shall include, without limitation, acts of the public enemy, restraining of government, unavailability of materials, strikes, civil riots, floods, hurricanes, 

  
 11 

 
tornadoes, earthquakes and other severe weather conditions or acts of God. In the event of any failure by Landlord to furnish any of the Required Services to any extent, or any cessation thereof,
due to malfunction of any equipment or machinery, or any other cause within the reasonable control of Landlord, Tenant shall have no claim for rebate of Rent or damages on account thereof, except as provided herein, provided that Landlord utilizes
its reasonable efforts to promptly repair said equipment or machinery and to restore said Required Services as soon thereafter as is reasonably practicable. If the interruption of Essential Required Services (as defined herein) is caused by the
negligence or willful misconduct of Landlord, its employees, contractors, subcontractors or agents or lies within Landlord’s reasonable control and such interruption renders any portion of the Leased Premises, as applicable, unusable by Tenant
for its intended purpose, then if such Essential Required Services are not restored within five (5) consecutive days following the initial interruption of Essential Required Services, Tenant shall receive an abatement of all Base Rent and
Additional Rent as to the portion of the Leased Premises, as applicable, rendered unusable for its intended purpose beginning on the sixth (6th) consecutive day following the initial interruption of Essential Required Services until such
Essential Required Services are restored. Furthermore, if such interruption of Essential Required Services renders the Leased Premises unusable for its intended purpose for more than sixty (60) consecutive days and Landlord fails to commence to
cure and thereafter diligently pursue the cure of such interruption within such sixty (60) consecutive day period, then Tenant may terminate this Lease Agreement by delivering written notice to Landlord at any time after the expiration of such
60-day period unless Landlord has commenced to cure such interruption. The foregoing Rent abatement and termination rights shall be Tenant’s sole recourse in the event of an interruption of an Essential Required Service. Landlord in no event
shall be liable for damages by reason of loss of profits, business interruption or other consequential damages. The provisions of this Section 7.C do not apply in the case of a casualty or condemnation under Sections 13 and 14 hereof, which
provisions shall govern in such circumstances. As used herein, the term “Essential Required Services” means any one or more of the following services to the extent Landlord is required to provide such service to Tenant under this
Lease Agreement: HVAC, electricity, water, and/or elevator service. 
 D. Tenant hereby acknowledges and agrees that Landlord is obligated
to provide only the Required Services under this Lease Agreement, and that Landlord, its agents and representatives, have made no representations whatsoever of any additional services or amenities to be provided by Landlord now or in the future
under this Lease Agreement. Notwithstanding the foregoing, Tenant recognizes that Landlord may, at Landlord’s sole option, elect to provide additional services or amenities for the tenants of the Building from time to time, and hereby agrees
that Landlord’s discontinuance of any provision of any such additional services or amenities shall not constitute a default of Landlord under this Lease Agreement nor entitle Tenant to any abatement of or reduction in Rent. 

E. Notwithstanding anything contained in this Section 7 to the contrary, Landlord shall have the right to install, at Tenant’s sole
cost and expense, meters or sub-meters within the Leased Premises for the purpose of metering or sub-metering water, electricity or any other utility provided to the Leased Premises, and may install, at its sole discretion and at Tenant’s sole
cost and expense, meters or sub-meters for the purpose of metering or sub-metering heating, air conditioning and ventilation. In the event that Landlord installs one or more of the aforementioned meters or sub-meters, Landlord shall provide an
invoice to Tenant for the utilities provided to the Leased Premises on a monthly basis in arrears based on the actual costs charged to Landlord for providing such utilities to the Leased Premises, which shall be paid by Tenant as Additional Rent on
or before the first day of the following calendar month, along with the remainder of the Additional Rent then due and owing by Tenant. In the alternative, Landlord shall have the continuing right to require Tenant to procure water, electricity
and/or any other utility directly from a reputable third party service provider (“Provider”) for Tenant’s own account in which case Tenant shall be responsible for the payment of such utilities directly to such Provider. In
such event, Tenant shall require each Provider to comply with the Building’s rules and regulations, all applicable laws, and Landlord’s reasonable policies and practices for the Building. Tenant acknowledges Landlord’s current policy
that requires all Providers utilizing any area of the Complex outside the Premises to be approved by Landlord and to enter into a written agreement reasonably acceptable to Landlord prior to gaining access to, or making any installations in or
through, such area. Accordingly, Tenant shall give Landlord written notice sufficient for such purposes. 
 SEC. 8 MAINTENANCE, REPAIRS AND USE: 

A. Landlord shall provide for the cleaning and maintenance of the public portions of the Building including painting and landscaping
surrounding the Building. Unless otherwise expressly stipulated herein, 

  
 12 

 
Landlord shall not be required to make any improvements or repairs of any kind or character on the Leased Premises during the Term, except such repairs as may be required by normal maintenance
operations to the exterior walls, corridors, windows, roof and other structural elements and equipment of the Building. 
 B. Landlord, its
officers, agents, designees and representatives shall have the right to enter all parts of the Leased Premises at all reasonable hours upon at least 24 hours’ advance notice (except in the event of an emergency or to provide janitorial service,
in which case no notice is required) for the purposes of: (i) inspecting same for compliance with Tenant’s obligations hereunder, (ii) cleaning, making repairs, alterations or additions to the Building or Leased Premises which it may
deem necessary or desirable, (iii) to provide any service which it is obligated to furnish to Tenant, or (iv) showing the Leased Premises to prospective purchasers, mortgagees, or prospective tenants (but with prospective tenants only,
during the last 6 months of the Term), and Tenant shall not be entitled to any abatement or reduction of Rent by reason thereof; provided, however, Landlord shall use commercially reasonable efforts not to disturb Tenant’s use of the Leased
Premises and accommodate Tenant’s preferred time of entry to the extent reasonable under the circumstances. Further, Tenant may elect to have a Tenant representative escort Landlord, its officers, agents, designees and representatives through
the Leased Premises provided such election shall not delay Landlord’s entry into the Leased Premises. Landlord shall use commercially reasonable efforts to cause all parties entering the Leased Premises on Landlord’s behalf or invitation
to keep all information learned about Tenant’s business operations during any such visit to the Leased Premises confidential and shall not disclose any such information to a third party. 

C. Landlord may, at its option and at the cost and expense of Tenant, repair or replace any damage or injury done to the Complex or any part
thereof, caused by Tenant, Tenant’s agents, employees, licensees, invitees or visitors; Tenant shall pay the reasonable cost thereof to Landlord within 30 days of demand. Tenant further agrees to maintain and keep the interior of the Leased
Premises in good repair and condition at Tenant’s expense. Tenant agrees not to commit or allow any waste or damage to be committed on any portion of the Leased Premises, and at the termination of this Lease Agreement, by lapse of time or
otherwise, to deliver up the Leased Premises to Landlord in as good condition as on the Leasehold Improvements Completion Date, ordinary wear and tear and casualty and condemnation damage alone excepted, and upon such termination of this Lease
Agreement, Landlord shall have the right to re-enter and resume possession of the Leased Premises. 
 D. Tenant will not use, occupy or
permit the use or occupancy of the Leased Premises for any purpose which is directly or indirectly forbidden by law, ordinance or governmental or municipal regulation or order, or which may be dangerous to life, limb or property; or permit the
maintenance of any public or private nuisance; or do or permit any other thing which may unreasonably interfere with, annoy or disturb the quiet enjoyment of any other tenant of the Building; or keep any substance or carry on or permit any operation
which might emit offensive odors or conditions into other portions of the Complex; or use any apparatus which might make undue noise or set up vibrations in the Complex; or permit anything to be done which would increase the fire and extended
coverage insurance rate on the Building or contents and if there is any increase in such rates by reason of acts of Tenant, then Tenant agrees to pay such increase promptly upon demand therefor by Landlord. In the event Tenant fails to correct, cure
or discontinue such prohibited or dangerous use within five (5) days following notice from the Landlord, such failure shall constitute an Event of Default by Tenant hereunder and Landlord shall have all of its remedies as set forth in this
Lease Agreement. 
 SEC. 9 QUIET ENJOYMENT; RIGHTS RESERVED: 

A. Tenant, on paying the said Rent and performing the covenants herein agreed to be by it performed, shall and may peaceably and quietly have,
hold and enjoy the Leased Premises for the said Term. 
 B. Notwithstanding anything herein to the contrary, provided no such actions
materially adversely affect Tenant’s access to or use of the Leased Premises or the Garage, Landlord hereby expressly reserves the right in its sole discretion to (i) temporarily or permanently change the location of, close, block or
otherwise alter any streets, driveways, entrances, corridors, doorways or walkways leading to or providing access to the Complex or any part thereof or otherwise restrict the use of same provided such activities do not unreasonably impair
Tenant’s access to the Leased Premises, or reduce the size or configuration of the Leased Premises, (ii) improve, remodel, add additional floors to or otherwise alter the Building, (iii) construct, alter, remodel or repair one or more
parking facilities (including garages) on the Land, and (iv) convey, transfer or dedicate portions of the Land. In addition, 

  
 13 

 
Landlord shall have the right, in its sole discretion, at any time during the Term to attach to any or all of the Building windows a glazing, coating or film or to install storm windows for the
purpose of improving the Building’s energy efficiency. Tenant shall not remove, alter or disturb any such glazing, coating or film. The addition of such glazing, coating or film, or the installation of storm windows or the exercise of any of
Landlord’s rights pursuant to this Section 9, shall in no way reduce Tenant’s obligations under this Lease Agreement or impose any liability on Landlord and it is agreed that Landlord shall not incur any liability whatsoever to Tenant
as a consequence thereof and such activities shall not be deemed to be a breach of any of Landlord’s obligations hereunder. Landlord agrees to exercise good faith in notifying Tenant within a reasonable time in advance of any alterations,
modifications or other actions of Landlord under this Section 9. Any diminution or shutting off of light, air or view by any structure which is now or may hereafter be effected on lands adjacent to the Building shall in no way affect this Lease
Agreement or impose any liability on Landlord. Noise, dust or vibration or other incidents caused by or arising out of any work performed pursuant to the exercise of Landlord’s rights reserved in this Section 9 or new construction of
improvements on lands adjacent to the Building, whether or not owned by Landlord, or on the Land shall in no way affect this Lease Agreement or impose any liability on Landlord. Tenant agrees to cooperate with Landlord in furtherance of
Landlord’s exercise of any of the rights specified in this Section 9. 
 SEC. 10 ALTERATIONS: 

A. Tenant shall not make or allow to be made (except as otherwise provided in this Lease Agreement) any alterations or physical additions
(including fixtures) in or to the Leased Premises (which for the purposes hereof includes the placement of safes, vaults and other heavy furniture or equipment), without first obtaining the written consent of Landlord; provided, however,
Landlord’s consent to (i) any alterations or physical additions (including fixtures) to the Leased Premises which do not affect the HVAC, plumbing, electrical or mechanical systems or structural elements of the Leased Premises or the
Building or (ii) the placement of safes, vaults or other heavy furniture or equipment within the Leased Premises, shall not be unreasonably withheld, conditioned or delayed. In addition, Tenant shall not be permitted to take x-rays or core
drill or penetrate the floor of the Leased Premises or any other floor of the Building without first obtaining the Landlord’s consent, which consent shall not be unreasonably withheld, conditioned or delayed. However, notwithstanding the
foregoing, Landlord acknowledges and agrees that Tenant may drill into the floor slab for plumbing associated with drainage, the location and scheduling thereof to be consented to by Landlord, which consent shall not be unreasonably withheld,
conditioned or delayed. The cost of any consultant or engineer hired by Landlord in connection with such work undertaken by Tenant shall be paid for by Tenant as additional rent hereunder. Tenant shall submit requests for consent to make alterations
or physical additions together with copies of the plans and specifications for such alterations. Subsequent to obtaining Landlord’s consent and prior to commencement of construction of the alterations or physical additions, Tenant shall deliver
to Landlord the building permit, a copy of the executed construction contract covering the alterations and physical additions and evidence of contractor’s and subcontractor’s insurance, such insurance being with such companies, for such
periods and in such amounts as Landlord may reasonably require, naming the Landlord Parties (as defined on Exhibit I) as additional insureds. Tenant shall pay to Landlord upon demand a review fee in the amount of Landlord’s actual
costs incurred to compensate Landlord for the cost of review and approval of the plans and specifications and for additional administrative costs incurred in monitoring the construction of the alterations, all such charges to Tenant to be
reasonable. Tenant shall deliver to Landlord a copy of the “as-built” plans and specifications for all alterations or physical additions so made in or to the Leased Premises, and shall reimburse Landlord for the cost incurred by Landlord
to update its current architectural plans for the Building. 
 B. Tenant shall indemnify, defend (with counsel reasonably acceptable to
Landlord) and hold harmless the Landlord Parties from and against all costs (including reasonable attorneys’ fees and costs of suit), losses, liabilities, or causes of action arising out of or relating to any alterations, additions or
improvements made by Tenant to the Leased Premises, including but not limited to any mechanics’ or materialmen’s liens asserted in connection therewith. 

C. Tenant shall not be deemed to be the agent or representative of Landlord in making any such alterations, physical additions or improvements
to the Leased Premises, and shall have no right, power or authority to encumber any interest in the Complex in connection therewith other than Tenant’s leasehold estate under this Lease Agreement. However, should any mechanics’ or other
liens be filed against any portion of the Complex or any interest therein (other than Tenant’s leasehold estate hereunder) by reason of Tenant’s acts or omissions or 

  
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because of a claim against Tenant or its contractors, Tenant shall cause the same to be canceled or discharged of record by bond or otherwise within twenty (20) days after notice by
Landlord. If Tenant shall fail to cancel or discharge said lien or liens, within said twenty (20) day period, which failure shall be deemed to be an Event of Default hereunder without the necessity of any further notice, Landlord may, at its
sole option and in addition to any other remedy of Landlord hereunder, cancel or discharge the same and upon Landlord’s demand, Tenant shall promptly reimburse Landlord for all costs incurred in canceling or discharging such lien or liens. 

D. Tenant shall cause all alterations, physical additions, and improvements (including fixtures), constructed or installed in the Leased
Premises by or on behalf of Tenant to comply with all applicable governmental codes, ordinances, rules, regulations and laws. Tenant acknowledges and agrees that neither Landlord’s review and approval of Tenant’s plans and specifications
nor its observation or supervision of the construction or installation thereof shall constitute any warranty or agreement by Landlord that same comply with such codes, ordinances, rules, regulations and laws or release Tenant from its obligations
under this Section 10.D. 
 E. Tenant shall be wholly responsible for any accommodations or alterations that are required by applicable
governmental codes, ordinances, rules, regulations and laws to be made to the Leased Premises to accommodate disabled employees and customers of Tenant, including, without limitation, compliance with the Americans with Disabilities Act (42 U.S.C.
§§ 12101 et seq.) and the Texas Architectural Barriers Act (Texas Government Code, Chapter 469) (collectively, the “Accommodation Laws”) to the extent interpreted and enforced from time to time, as well as all applicable
regulatory requirements promulgated by the Centers for Medicare and Medicaid Services (“CMS”), the State of Texas, Occupational Safety and Health Administration and the administrative regulations promulgated thereunder and all other
federal, state and local statutory and regulatory requirements and building codes, including, without limitation, state hospital licensing standards and CMS certification regulations (collectively, the “Healthcare Laws”). Except to
the extent provided below, Landlord shall be responsible for making all accommodations and alterations to the Common Areas of the Building necessary to comply with the Accommodation Laws and any other federal, state and local statutory and
regulatory requirements and building codes. Notwithstanding the foregoing, Landlord may perform, at Tenant’s sole cost and expense, any accommodations or alterations that are required by the Accommodation Laws and/or Healthcare Laws or that are
required by any governmental official acting pursuant to the Accommodation Laws and/or Healthcare Laws to any area outside of the Leased Premises which are triggered by any alterations or additions to the Leased Premises or by the proposed use of
the Premises as described in Section 3 and Tenant shall reimburse Landlord for such cost and expense within thirty (30) days of demand. 
 SEC.
11 FURNITURE, FIXTURES AND PERSONAL PROPERTY: Tenant may remove its trade fixtures, office supplies and movable office furniture and equipment not attached to the Building provided: (a) such removal is made prior to the termination of this
Lease Agreement; (b) Tenant is not in default of any obligation or covenant under this Lease Agreement at the time of such removal; and (c) Tenant promptly repairs all damage caused by such removal. All other property at the Leased
Premises and any alterations or additions to the Leased Premises (including wall-to-wall carpeting, paneling or other wall covering) and any other article attached or affixed to the floor, wall or ceiling of the Leased Premises (excluding lab
benches which will be considered movable equipment not attached to the Building and which may be removed by Tenant in accordance with the first sentence of this Section 11) shall become the property of Landlord and shall remain upon and be
surrendered with the Leased Premises as a part thereof at the termination of the Lease Agreement by lapse of time or otherwise, Tenant hereby waiving all rights to any payment or compensation therefor. Tenant will, prior to termination of this Lease
Agreement, remove any and all alterations, additions, fixtures, equipment and property placed or installed by Tenant in the Leased Premises and will repair any damage caused by such removal; provided, however, Tenant shall not be obligated to remove
any alterations or physical additions that affect the Leased Premises or the Building if at such time as Landlord approves any such alterations or physical additions pursuant to Section 10 above, Landlord notifies Tenant in writing that
Landlord requires such items not be removed upon the expiration or termination of this Lease Agreement. In addition, Tenant shall be required prior to the termination of this Lease Agreement to remove all of its telecommunications equipment,
including, but not limited to, all switches, cabling, wiring, conduit, racks and boards, whether located in the Leased Premises or in the Common Areas. If Tenant does not complete all removals prior to the termination of this Lease Agreement,
Landlord may remove such items (or contract for the removal of such items), Tenant shall reimburse Landlord upon demand for the reasonable costs incurred by Landlord in connection therewith and Tenant shall be deemed to be holding over pursuant to
Section 26 below until such time as such items have been removed from the Leased Premises. This Section 11 shall survive the expiration or termination of this Lease Agreement. 

  
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 SEC. 12 SUBLETTING AND ASSIGNMENT: 

A. In the event Tenant should desire to assign this Lease Agreement or sublet the Leased Premises or any part thereof or allow same to be used
or occupied by others, Tenant shall give Landlord written notice (which shall specify the duration of said desired sublease or assignment, the date same is to occur, the exact location of the space affected thereby, the proposed rentals on a square
foot basis chargeable thereunder and sufficient information of the proposed sublessee or assignee regarding its intended use, financial condition and business operations) of such desire at least fifteen (15) days in advance of the date on which
Tenant desires to make such assignment or sublease or allow such a use or occupancy. Landlord shall then have a period of ten (10) days following receipt of such notice within which to notify Tenant in writing that Landlord elects: 

 

	 	(1)	in the event such assignee or sublessee fails to meet the conditions set forth in subparagraph (3) below, to refuse to permit Tenant to assign this Lease Agreement or sublet such space, and in such case this Lease
Agreement shall continue in full force and effect in accordance with the terms and conditions hereof; or 

  

	 	(2)	to terminate this Lease Agreement as to the space so affected as of the date so specified by Tenant in which event Tenant shall be relieved of all obligations hereunder as to such space arising from and after such date;
provided, however, that if Landlord elects to terminate this Lease Agreement pursuant to this Section 12.A(2), Tenant shall have ten (10) days after receipt of written notice of Landlord’s election during which Tenant may, if it so
desires, withdraw its request for Landlord’s consent to such assignment or sublease, in which event this Lease Agreement shall remain in full force and effect as if such request for Landlord’s consent had not been made; or

  

	 	(3)	 to permit Tenant to assign this Lease Agreement or sublet such space for the duration specified in such notice, such approval not to be unreasonably
withheld, conditioned or delayed, if (a) the nature and character of the proposed assignee or sublessee and the principals thereof; their business and activities and intended use of the Leased Premises are in Landlord’s reasonable judgment
consistent with the current standards of the Building and the floor or floors on which the Leased Premises are located, (b) neither the proposed assignee or sublessee (nor any party which, directly or indirectly, controls or is controlled by or
is under common control with the proposed assignee or sublessee) is a department, representative or agency of any governmental body or then an occupant of any part of the Building or a party with whom Landlord is then negotiating to lease space in
the Building or in any adjacent Building owned by Landlord or an affiliate of Landlord in and in the vicinity of the Texas Medical Center area of Houston, Texas, (c) the form and substance of the proposed sublease or instrument of assignment
are acceptable to Landlord (which acceptance by Landlord shall not be unreasonably withheld, conditioned or delayed) and is expressly subject to all of the terms and provisions of this Lease Agreement and to any matters to which this Lease Agreement
is subject, (d) the proposed occupancy would not (1) increase Landlord’s cleaning requirements, (2) impose an extra burden upon the services to be supplied by Landlord to Tenant hereunder, (3) violate the current rules and
regulations of the Building, (4) violate the provisions of any other leases of tenants in the Building or (5) cause alterations or additions to be made to the Building (excluding the Leased Premises), (e) Tenant enters into a written
agreement with Landlord whereby it is agreed that fifty percent (50%) of any rent realized by Tenant as a result of said sublease or assignment in excess of the Base Rent and Additional Rent payable to Landlord by Tenant under this Lease
Agreement and any and all sums and other considerations of whatsoever nature paid to Tenant by the assignee or sublessee for or by reason of such assignment or sublease, including, but not limited to, sums paid for the sale of Tenant’s
fixtures, leasehold improvements, equipment, furniture, furnishings or other personal property in excess of the fair market value thereof (that is, after 

  
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deducting and giving Tenant credit for Tenant’s reasonable costs directly associated therewith, including reasonable brokerage fees, reasonable marketing costs, reasonable attorney’s
fees and the reasonable cost of remodeling or otherwise improving the Leased Premises for said assignee or sublessee but excluding any free rentals or the like offered to any such sublessee or assignee) shall be payable to Landlord such payments are
actually received by Tenant, (f) the granting of such consent will not constitute a default under any other agreement to which Landlord is a party or by which Landlord is bound and (g) the creditworthiness of the proposed assignee or
sublessee and the principals thereof is acceptable to Landlord, in Landlord’s reasonable discretion. 

 B. No assignment
or subletting by Tenant shall be effective unless Tenant shall execute, have acknowledged and deliver to Landlord, and cause each sublessee or assignee to execute, have acknowledged and deliver to Landlord, an instrument in form and substance
reasonably acceptable to Landlord in which (i) such sublessee or assignee adopts this Lease Agreement and assumes and agrees to perform jointly and severally with Tenant, all of the obligations of Tenant under this Lease Agreement, as to the
space transferred to it, (ii) Tenant and such sublessee or assignee agree to provide to Landlord, at their expense, direct access from a public corridor in the Building to the transferred space, (iii) such sublessee or assignee agrees to
use and occupy the transferred space solely for the purpose specified in Section 3 and otherwise in strict accordance with this Lease Agreement and (iv) Tenant acknowledges and agrees that, notwithstanding such subletting or assignment,
Tenant remains directly and primarily liable for the performance of all the obligations of Tenant hereunder (including, without limitation, the obligation to pay Rent), and Landlord shall be permitted to enforce this Lease Agreement against Tenant
or such sublessee or assignee, or both, without prior demand upon or proceeding in any way against any other persons. Tenant shall, upon demand, reimburse Landlord for all reasonable out-of-pocket expenses incurred by Landlord in connection with a
request made by Tenant pursuant to this Section 12, including, without limitation, any investigations as to the acceptability of the proposed assignee or sublessee, and all legal costs reasonably incurred in connection with the granting of any
requested consent. 
 C. Any consent by Landlord to a particular assignment or sublease shall not constitute Landlord’s consent to any
other or subsequent assignment or sublease, and any proposed sublease or assignment by any assignee or sublessee shall be subject to the provisions of this Section 12 as if it were a proposed sublease or assignment by Tenant. The prohibition
against an assignment or sublease described in this Section 12 shall be deemed to include a prohibition against (i) Tenant’s mortgaging or otherwise encumbering its leasehold estate, (ii) an assignment or sublease which may occur
by merger or operation of law and (iii) permitting the use or occupancy of the Leased Premises, or any part thereof, by anyone other than Tenant, each of which shall be ineffective and void and shall constitute an Event of Default under this
Lease Agreement unless consented to by Landlord in writing in advance, which consent shall not be unreasonably withheld, conditioned or delayed. For purposes hereof, the transfer of the ownership or voting rights in a controlling interest of the
voting stock of Tenant (if Tenant is a corporation) or the transfer of a general partnership interest or a majority of the limited partnership interest in Tenant (if Tenant is a partnership), at any time throughout the Term, shall be deemed to be an
assignment of this Lease Agreement. 
 D. Notwithstanding anything to the contrary contained herein, Tenant may assign this Lease Agreement
or sublet the Leased Premises or any part thereof, without the prior consent of Landlord, to (i) an Affiliate (as defined below) of Tenant, (ii) an entity into which Tenant is merged, consolidated or converted (or the resulting entity in
any merger of any other entity into or with Tenant), or (iii) an entity to which fifty percent (50%) or more of Tenant’s assets are transferred (each a “Permitted Transferee”); provided, however, (a) Tenant shall
give Landlord written notice (which shall specify the assignee or sublessee, the duration of said assignment or sublease, the effective date of such assignment or subletting, the financial information necessary for Landlord to confirm the net worth
test set forth below has been satisfied and the exact location of the space affected thereby and the rentals on a square foot basis to be charged thereunder) of such assignment or sublease at least ten (10) business days prior to such
assignment or sublease, and (b) the assignee or successor entity must carry on the same use from the Leased Premises as Tenant and have a net worth as determined by generally accepted accounting principles (“GAAP”) on the date
following such sale of assets or merger at least equal to the GAAP net worth of Tenant as of the day preceding such assignment, sublease, sale or merger. In the event of any subletting or assignment to a Permitted Transferee, one hundred percent
(100%) of the rent received from such Permitted Transferee shall be retained by Tenant. Further, any Permitted Transferee under an assignment of the Lease Agreement or the 

  
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subletting of all of the Leased Premises shall have the right to exercise Tenant’s Right of First Refusal, Tenant’s Preferential Right, the Renewal Option and any rights to the
Hold Space. As used herein, (1) the term “Affiliate” means any person or entity controlled by, under common control with, or which controls, the Tenant, and (2) the term “control” means the possession,
directly or indirectly, of the power to direct or cause the direction of the management and policies of the entity referred to, whether through ownership of voting securities, by contract or otherwise, and the terms “controlling”
and “controls” have meanings correlative to the foregoing. 
 SEC. 13 FIRE AND OTHER CASUALTY: 

A. In the event of a fire or other casualty in the Leased Premises, Tenant shall immediately give notice thereof to Landlord. If the Leased
Premises shall be partially destroyed by fire or other casualty so as to render the Leased Premises untenantable in whole or in part. Rent shall abate thereafter as to the portion of the Leased Premises rendered untenantable until such time as the
Leased Premises are made tenantable as reasonably determined by Landlord and Landlord agrees to commence and prosecute such repair work promptly and with all due diligence; provided, however, in the event such destruction (i) results in total
or substantial damages to or destruction of the Building and Landlord shall decide not to rebuild or (ii) results in the Leased Premises being untenantable in whole or in substantial part and the reasonable estimation of a responsible
contractor selected by Landlord as to the amount of time necessary to rebuild or restore such destruction to the Leased Premises and all other portions of the Building exceeds six (6) months from the time such work is commenced, then in either
event, Landlord shall have a right to terminate this Lease Agreement effective as of the date of casualty or destruction, and upon such termination, all Rent owed up to the time of such destruction or termination shall be paid by Tenant. Subject to
reasonable delays for insurance adjustments, Landlord shall give Tenant written notice of its decisions, estimates or elections under this Section 13 within sixty (60) days after any such damage or destruction. If any portion of Rent is
abated under this Section 13, Landlord may elect to extend the expiration date of the Term of this Lease Agreement for the period of the abatement. Notwithstanding any provision herein to the contrary, if such casualty to the Leased Premises
occurs during the last 12 months of the Term, or the repairs required will, in the reasonable estimation of the contractor selected by Landlord, take twelve (12) months or longer to repair, Tenant may terminate this Lease Agreement by
delivering written notice to Landlord within thirty (30) days of Landlord’s delivery to Tenant of the estimation of the time period necessary to make the repairs, such termination to be effective as of the date of casualty or destruction,
and upon such termination, all Rent owed up to the time of such destruction or termination shall be paid by Tenant. 
 B. Notwithstanding
anything in this Lease Agreement to the contrary, if the Leased Premises are damaged by fire or other casualty resulting from the gross negligence or willful misconduct of Tenant, or the agents, employees, licensees, customers or invitees of Tenant,
such damage shall be repaired by and at the expense of Tenant under the direction and supervision of Landlord, and this Lease Agreement shall not be terminated and Rent shall continue without abatement. 

C. Notwithstanding anything contained in this Section 13, in no event shall Landlord be required to expend more to reconstruct, restore
and repair the Building than the amount actually received by Landlord from the proceeds of the property insurance carried by Landlord and Landlord (or which would have been received had Landlord carried the insurance required to be carried
hereunder) shall have no duty to repair or restore any portion of any alterations, additions, installation or improvements in the Leased Premises or the decorations thereto except to the extent that the proceeds of the insurance carried by Tenant
are timely received by Landlord. If Tenant desires any other additional repairs or restoration, and if Landlord consents thereto, it shall be done at Tenant’s sole cost and expense subject to all of the applicable provisions of this Lease
Agreement. Tenant acknowledges that Landlord shall be entitled to the full proceeds of any insurance coverage whether carried by Landlord or Tenant, for damage to any alterations, addition, installation, improvements or decorations which would
become the Landlord’s property upon the termination of this Lease Agreement. 
 SEC. 14 CONDEMNATION: If all of the Complex is taken or
condemned, or acquired under threat of condemnation, by or at the direction of any governmental authority (a “Taking” or “Taken”, as the context requires), or if so much of the Complex is Taken that, in
Landlord’s opinion, the remainder cannot be restored to an economically viable, quality office building, or if the awards payable to Landlord as a result of any Taking are, in Landlord’s opinion, inadequate to restore the remainder to an
economically viable, quality office building, Landlord may, at its election, exercisable by the giving of written notice to Tenant within sixty (60) days after the date of the 

  
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Taking, terminate this Lease Agreement as of the date of the Taking or the date Tenant is deprived of possession of the Leased Premises (whichever is later). If this Lease Agreement is not
terminated as a result of a Taking, Landlord shall restore the Leased Premises remaining after the Taking to a Building standard condition. During the period of restoration, Base Rent shall be abated to the extent the Leased Premises are rendered
untenantable and, after the period of restoration, Base Rent and Tenant’s pro rata share shall be reduced in the proportion that the area of the Leased Premises Taken or otherwise rendered untenantable bears to the area of the Leased Premises
just prior to the Taking. If any portion of Base Rent is abated under this Section 14, Landlord may elect to extend the expiration date of the Term for the period of the abatement. All awards, proceeds, compensation or other payments from or
with respect to any Taking of the Complex or any portion thereof shall belong to Landlord, Tenant hereby assigning to Landlord all of its right, title, interest and claim to same. Tenant shall have the right to assert a claim for and recover from
the condemning authority, but not from Landlord, such compensation as may be awarded on account of Tenant’s moving and relocation expenses, and depreciation to and loss of Tenant’s movable personal property. 

SEC. 15 DEFAULT BY TENANT: The occurrence of any one or more of the following shall constitute an “Event of Default” under this Lease
Agreement: 
 A. The failure of Tenant to pay any Rent as and when due under this Lease Agreement and such failure continues for five
(5) business days after Landlord gives Tenant written notice of such failure; provided, however, that once Landlord has given Tenant two (2) such notices during any calendar year of this Lease Agreement for any payments that are not made
when due hereunder, Landlord shall not be required to give further notice or any notice at all with respect to subsequent defaults in such payments in such calendar year, and the failure or refusal by Tenant to timely make any payment thereafter due
hereunder during such calendar year shall immediately constitute an Event of Default entitling Landlord to pursue its remedies without notice or demand; 

B. The failure of Tenant to perform, comply with or observe any of the other covenants or conditions contained in this Lease Agreement and the
continuance of such failure for the period of time as may be specified elsewhere in this Lease Agreement for such specific covenant or condition, or should no period of time be specified elsewhere in this Lease Agreement with respect to such
specific covenant or condition, a period of thirty (30) days after written notice to Tenant; or, if such failure cannot reasonably be cured within said thirty (30) day period despite Tenant’s diligent good faith efforts, the failure
of Tenant to promptly commence its diligent good faith efforts to cure such failure within said thirty (30) day period and/or the continuance of such failure for a period of ninety (90) days notwithstanding Tenant’s efforts to cure;

 C. Tenant shall fail to execute and acknowledge or otherwise respond in good faith and in writing within ten (10) days after
submission to Tenant of a request for confirmation of the subordination of this Lease Agreement pursuant to Section 24 or an estoppel certificate pursuant to Section 35; 

D. Intentionally Deleted; 
 E.
The filing of a petition by or against Tenant or any guarantor of Tenant’s obligations under this Lease Agreement (i) naming Tenant or any guarantor as debtor in any bankruptcy or other insolvency proceeding, (ii) for the appointment
of a liquidator or receiver for all or substantially all of Tenant’s or any guarantor’s property or for Tenant’s interest in this Lease Agreement, or (iii) to reorganize or modify Tenant’s or any guarantor’s capital
structure; 
 F. The admission by Tenant or any guarantor in writing of its inability to meet its obligations as they become due or the
making by Tenant or any guarantor of an assignment for the benefit of its creditors; 
 G. The attempt by Tenant to assign this Lease
Agreement or to sublet all or any part of the Leased Premises to other than a Permitted Transferee (or to a Permitted Transferee in a manner that does not comply with Section 12.D.) without the prior written consent of Landlord in accordance
with Section 12; 
 H. Any holding over by Tenant in accordance with Section 26 with respect to all or any portion of the Leased
Premises after the expiration or termination of the Lease Agreement; or 
 I. The failure by Tenant to comply with the insurance
requirements set forth in Exhibit I. 

  
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 SEC. 16 REMEDIES OF LANDLORD: Upon any Event of Default, Landlord may exercise any one or more of the
following described remedies, in addition to all other rights and remedies provided at law or in equity: 
 A. Terminate this Lease
Agreement by written notice to Tenant and forthwith repossess the Leased Premises and be entitled to recover forthwith as damages a sum of money equal to the total of (i) the cost of recovering the Leased Premises (including reasonable
attorneys’ fees and costs of suit), (ii) the reasonable cost of removing and storing any personal property, (iii) the unpaid Rent earned at the time of termination, plus interest thereon at the rate described in Section 5,
(iv) the present value (discounted at the rate of eight percent (8%) per annum) of the balance of the Rent for the remainder of the Term less the present value (discounted at the same rate) of the fair market rental value of the Leased
Premises for said period, taking into account the period of time the Leased Premises will remain vacant until a new tenant is obtained, and the reasonable cost to prepare the Leased Premises for occupancy and the other reasonable costs (such as
leasing commissions, tenant improvement allowances and attorneys’ fees) to be incurred by Landlord in connection therewith, and (v) any other sum of money and damages owed by Tenant to Landlord under this Lease Agreement. 

B. Terminate Tenant’s right of possession (but not this Lease Agreement) and may repossess the Leased Premises by forcible detainer suit
or otherwise, without thereby releasing Tenant from any liability hereunder and without demand or notice of any kind to Tenant and without terminating this Lease Agreement. Landlord shall use reasonable efforts under the circumstances to relet the
Leased Premises on such terms and conditions as Landlord in its sole discretion may determine (including a term different than the Term, rental concessions, alterations and repair of the Leased Premises); provided, however, Landlord hereby reserves
the right (i) to lease any other comparable space available in the Building or in any adjacent building owned by Landlord prior to offering the Leased Premises for lease, and (ii) to refuse to lease the Leased Premises to any potential
tenant which does not meet Landlord’s standards and criteria for leasing other comparable space in the Building. Landlord shall not be liable for, nor shall Tenant’s obligations hereunder be diminished because of, Landlord’s failure
or refusal to relet the Leased Premises or collect rent due in respect of such reletting. For the purpose of such reletting Landlord shall have the right to decorate or to make any repairs, changes, alterations or additions in or to the Leased
Premises as may be reasonably necessary or desirable. In the event that (i) Landlord shall fail or refuse to relet the Leased Premises, or (ii) the Leased Premises are relet and a sufficient sum shall not be realized from such reletting
(after first deducting therefrom, for retention by Landlord, the unpaid Rent due hereunder earned but unpaid at the time of reletting plus interest thereon at the rate specified in Section 5, the reasonable cost of recovering possession
(including reasonable attorneys’ fees and costs of suit), all of the reasonable costs and expenses of such decorations, repairs, changes, alterations and additions, the reasonable expense of such reletting and the reasonable cost of collection
of the rent accruing therefrom) to satisfy the Rent, then Tenant shall pay to Landlord as damages a sum equal to the amount of such deficiency. Any such payments due Landlord shall be made upon demand therefor from time to time and Tenant agrees
that Landlord may file suit to recover any sums falling due under the terms of this Section 16 from time to time. No delivery to or recovery by Landlord of any portion due Landlord hereunder shall be any defense in any action to recover any
amount not theretofore reduced to judgment in favor of Landlord, nor shall such reletting be construed as an election on the part of Landlord to terminate this Lease Agreement unless a written notice of such intention be given to Tenant by Landlord.
Notwithstanding any such termination of Tenant’s right of possession of the Leased Premises, Landlord may at any time thereafter elect to terminate this Lease Agreement. In any proceedings to enforce this Lease Agreement under this
Section 16, Landlord shall be presumed to have used its reasonable efforts to relet the Leased Premises, and Tenant shall bear the burden of proof to establish that such reasonable efforts were not used. 

C. Alter any and all locks and other security devices at the Leased Premises, and if it does so Landlord shall not be required to provide a
new key or other access right to Tenant unless Tenant has cured all Events of Default; provided, however, that in any such instance, during Landlord’s normal business hours and at the convenience of Landlord, and upon the written request of
Tenant accompanied by such written waivers and releases as Landlord may require, Landlord will escort Tenant or its authorized personnel to the Leased Premises to retrieve any personal belongings or other property of Tenant not subject to the
Landlord’s lien or security interest described in Section 17. The provisions of this Section 16.0 are intended to override and control any conflicting provisions of the Texas Property Code. 

  
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 D. All agreements and provisions to be performed by Tenant under any of the terms of this Lease
Agreement shall be at Tenant’s sole cost and expense and without any abatement of Rent, except as otherwise provided in this Lease Agreement. If Tenant shall fail to pay any sum of money, other than Base Rent, required to be paid by it
hereunder or shall fail to cure any default and such failure shall continue for ten (10) days after notice thereof by Landlord, then Landlord may, but shall not be obligated so to do, and without waiving or releasing Tenant from any
obligations, make any such payment or perform any such act on Tenant’s part. All sums so paid by Landlord and all reasonable costs incurred by Landlord in taking such action shall be deemed Additional Rent hereunder and shall be paid to
Landlord on demand, and Landlord shall have (in addition to all other rights and remedies of Landlord) the same rights and remedies in the event of the non-payment thereof by Tenant as in the case of default by Tenant in the payment of Rent. 

E. In connection with the exercise by Landlord of its rights and remedies in respect of any Event of Default on the part of Tenant, to the
extent (but no further) that Landlord is required by applicable Texas law to mitigate damages, or to use efforts to do so, and such requirement cannot be lawfully and effectively waived (it being the intention of Landlord and Tenant that such
requirements be and are hereby WAIVED to the maximum extent permitted by applicable law), Tenant agrees in favor of Landlord that Landlord shall not be deemed to have failed to mitigate damages, or to have used the efforts required by law to do so,
because: 
  

	 	(1)	Landlord leases other space in the Building prior to re-letting the Leased Premises; 

  

	 	(2)	Landlord refuses to relet the Leased Premises to any Affiliate of Tenant, or any principal of Tenant, or any Affiliate of such principal; 

 

	 	(3)	Landlord refuses to relet the Leased Premises to any person or entity whose creditworthiness Landlord in good faith deems unacceptable; 

 

	 	(4)	Landlord refuses to relet the Leased Premises to any person or entity because the use proposed to be made of the Leased Premises by such prospective tenant is not of a type and nature consistent with that of the other
tenants in the Building or the floor where the Leased Premises are situated as of the date Tenant defaults under this Lease Agreement, or because such use would, in the good faith opinion of Landlord, impose unreasonable or excessive demands upon
the Building; 

  

	 	(5)	Landlord refuses to relet the Leased Premises to any person or entity, or any affiliate of such person or entity, who has been engaged in litigation with, or who has threatened litigation against, Landlord or any of its
affiliates, or whom Landlord in good faith deems to be unreasonably or excessively litigious; 

  

	 	(6)	Landlord refuses to relet the Leased Premises because the tenant or the terms and provisions of the proposed lease are not approved by the holders of any liens or security interests in the Building or any part thereof,
or would cause Landlord to breach or be in default of, or to be unable to perform any of its covenants under, any agreements between Landlord and any third party; 

 

	 	(7)	Landlord refuses to relet the Leased Premises because the proposed tenant is unwilling to execute and deliver Landlord’s standard lease form without substantial tenant-oriented modifications or such tenant requires
improvements to the Leased Premises to be paid at Landlord’s cost and expense; or 

  

	 	(8)	Landlord refuses to relet the Leased Premises to a person or entity whose character or reputation, or the nature of whose business, Landlord in good faith deems unacceptable; 

and it is further agreed that each and all of the grounds for refusal set forth in clauses (1) through (8) above, both inclusive, of
this sentence are reasonable grounds for Landlord’s refusal to relet the Leased Premises, or (as to all other provisions of this Lease Agreement) for Landlord’s refusal to issue any approval, or take any other action, 

  
 21 

 of any nature whatsoever under this Lease Agreement. In the event the waiver set forth in this Section 16.E
shall be ineffective, Tenant further agrees in favor of Landlord, to the maximum extent to which it may lawfully and effectively do so, that the following efforts to mitigate damages if made by Landlord (and without obligating Landlord to render
such efforts) shall be conclusively deemed reasonable, and that Landlord shall be conclusively deemed to have used the efforts to mitigate damages required by applicable law if: Landlord places the Leased Premises on its inventory of available space
in the Building; Landlord makes such inventory available to brokers who request same; and Landlord shows the Leased Premises to prospective tenants (or their brokers) who request to see it. 

SEC. 17 LIEN FOR RENT: LANDLORD HEREBY WAIVES ANY STATUTORY LANDLORD’S LIEN TO WHICH LANDLORD MAY OTHERWISE BE ENTITLED. 

SEC. 18 NON-WAIVER: Neither acceptance of Rent by Landlord nor failure by Landlord to exercise available rights and remedies, whether singular or
repetitive, shall constitute a waiver of any of Landlord’s rights hereunder. Waiver by Landlord of any right for any Event of Default of Tenant shall not constitute a waiver of any right for either a subsequent Event of Default of the same
obligation or any other Event of Default. No act or thing done by Landlord or its agent shall be deemed to be an acceptance or surrender of the Leased Premises and no agreement to accept a surrender of the Leased Premises shall be valid unless it is
in writing and signed by a duly authorized officer or agent of Landlord. 
 SEC. 19 LAWS AND REGULATIONS; RULES AND REGULATIONS: Tenant shall comply
with, and Tenant shall use commercially reasonable efforts to cause its visitors, employees, contractors, agents, invitees and licensees to comply with, all laws, ordinances, orders, rules and regulations of any state, federal, municipal and other
agencies or bodies having any jurisdiction thereof relating to the use, condition or occupancy of the Leased Premises, including, without limitation, all Healthcare Laws. Such reasonable written rules and regulations applying to all tenants in the
Building as may be hereafter adopted by Landlord for the safety, care and cleanliness of the premises and the preservation of good order thereon, are hereby made a part hereof for all purposes and Tenant agrees to comply with all such rules and
regulations. Landlord shall have the right at all times to change such rules and regulations or to amend them in any reasonable manner as may be deemed advisable by Landlord (provided such changes do not materially adversely affect Tenant’s use
of the Leased Premises for the uses set forth in Section 3), all of which changes and amendments will be sent by Landlord to Tenant in writing and shall be thereafter carried out and observed by Tenant. The current rules and regulations of the
Building are set forth in Exhibit D attached hereto and made a part hereof for all purposes. Landlord shall use commercially reasonable efforts to enforce the rules and regulations in a non-discriminatory manner. 

SEC. 20 ASSIGNMENT BY LANDLORD; LIMITATION OF LANDLORD’S LIABILITY: Landlord shall have the right to transfer and assign, in whole or in part, all
its rights and obligations hereunder and in the Complex, and in such event and upon such transferee’s assumption of all obligations of Landlord accruing after the date of such transfer, no further liability or obligation shall thereafter accrue
against Landlord hereunder. Furthermore, Tenant specifically agrees to look solely to Landlord’s interest in the Complex for the recovery of any judgment from Landlord, it being agreed that the Landlord Parties shall never be personally liable
for any such judgment. 
 SEC. 21 SEVERABILITY: This Lease Agreement shall be construed in accordance with the laws of the State of Texas. If any
clause or provision of this Lease Agreement is illegal, invalid or unenforceable, under present or future laws effective during the Term hereof, then it is the intention of the parties hereto that the remainder of this Lease Agreement shall not be
affected thereby, and it is also the intention of both parties that in lieu of each clause or provision that is illegal, invalid or unenforceable, there be added as part of this Lease Agreement a clause or provision as similar in terms to such
illegal, invalid or unenforceable clause or provision as may be possible and be legal, valid and enforceable. 
 SEC. 22 SIGNS: No signs of any kind
or nature, symbol or identifying mark shall be put on the Building, in the halls, elevators, staircases, entrances, parking areas or upon the doors or walls, whether plate glass or otherwise, of the Leased Premises or within the Leased Premises so
as to be visible from the public areas or exterior of the Building without the prior written approval of Landlord, which approval shall not be unreasonably withheld, conditioned or delayed. All signs or lettering shall conform in all respects to the
sign and/or lettering criteria established by Landlord in writing. Landlord, at its sole cost and expense, shall provide Building standard signage on the north public corridor wall immediately adjacent to Tenant’s entrance opposite the elevator
lobby on the north side of the eighth (8th) floor. 

  
 22 

 SEC. 23 SUCCESSORS AND ASSIGNS: Landlord and Tenant agree that all provisions hereof are to be construed
as covenants and agreements as though the words imparting such covenants were used in each separate paragraph hereof, and that, except as restricted by the provisions of Section 12, this Lease Agreement and all the covenants herein contained
shall be binding upon the parties hereto, their respective heirs, legal representatives, successors and assigns. 
 SEC. 24 SUBORDINATION: 

A. Tenant covenants and agrees with Landlord that this Lease Agreement is subject and subordinate to any mortgage, deed of trust, ground lease
and/or security agreement which may now or hereafter encumber the Complex or any interest of Landlord therein and/or the contents of the Building, and to any advances made on the security thereof and to any and all increases, renewals,
modifications, consolidations, replacements and extensions thereof; provided any such subordination to a mortgage, deed of trust, ground lease and/or security agreement executed after the Effective Date shall be upon the express condition that this
Lease Agreement shall be recognized by the mortgagee or ground lessor and that the rights of Tenant shall remain in full force and effect during the Term so long as Tenant shall continue to perform all the covenants and conditions of this Lease
Agreement. In confirmation of such subordination, however, at Landlord’s request Tenant shall execute promptly any appropriate certificate or instrument that Landlord may request, provided such subordination includes a commercially reasonable
non-disturbance provision. hi the event of the enforcement by the ground lessor, the trustee, the beneficiary or the secured party under any such ground lease, mortgage, deed of trust or security agreement of the remedies provided for by law or by
such ground lease, mortgage, deed of trust or security agreement, Tenant will automatically become the Tenant of such ground lessor or successor in interest without any change in the terms or other provisions of this Lease Agreement; provided,
however, that such ground lessor or successor in interest shall not be (a) bound by any payment of Rent for more than one month in advance except prepayments in the nature of security for the performance by Tenant of its obligations under this
Lease Agreement to the extent such prepayments have been delivered to such successor in interest, (b) bound by any amendment or modification of this Lease Agreement made without the written consent of such ground lessor or such successor in
interest (c) liable for any previous act or omission of the Landlord, (d) subject to any credit, demand, claim, counterclaim, offset or defense which theretofore accrued to Tenant against the Landlord, (e) required to account for any
security deposit of Tenant other than any security deposit actually delivered to lender by Landlord and (f) responsible for any monies owing by Landlord to Tenant. Upon request by such ground lessor or successor in interest, whether before or
after the enforcement of its remedies, Tenant shall execute and deliver an instrument or instruments confirming and evidencing the attornment herein set forth. Notwithstanding anything contained in this Lease Agreement to the contrary, in the event
of any default by Landlord in performing its covenants or obligations hereunder which would give Tenant the right to terminate this Lease Agreement, Tenant shall not exercise such right unless and until (a) Tenant gives written notice of such
default (which notice shall specify the exact nature of said default and how the same may be cured) to the lessor under any such land or ground lease and the holder(s) of any such mortgage or deed of trust or security agreement who has theretofore
notified Tenant in writing of its interest and the address to which notices are to be sent, and (b) said lessor and holder(s) fail to cure or cause to be cured said default within thirty (30) days from the receipt of such notice from
Tenant. This Lease Agreement is further subject to and subordinate to all matters of record in Harris County, Texas. 
 B. Additionally,
within thirty (30) days of the Effective Date of this Lease Agreement, Landlord will use commercially reasonable efforts to cause all mortgagees, lenders, ground lessors and other parties currently holding a security interest affecting the
Leased Premises or the Complex to execute a subordination, nondisturbance and attornment agreement substantially in the form attached hereto as Exhibit M (the “SNDA”). Consequently, if Landlord fails for any reason
whatsoever, other than the failure of Tenant to provide Landlord for forwarding to the lender with such information regarding Tenant, its operations, finances, and principals, as the lender may request, or to act reasonably in respect of the
proposed wording of the SNDA, or to act expeditiously to execute the SNDA, to obtain and deliver to Tenant the SNDA signed by such lender within thirty (30) days after the Effective Date of this Lease Agreement, Tenant shall have the right, in
its sole discretion by written notice to Landlord, to terminate this Lease Agreement at any time prior to Tenant’s receipt of the SNDA executed by such lender. 

C. Notwithstanding anything to the contrary set forth above, any beneficiary under any deed of trust may at any time subordinate its deed of
trust to this Lease Agreement in whole or in part, without any need to obtain Tenant’s consent, by execution of a written document subordinating such deed of trust to the Lease Agreement to the extent set forth in such document and thereupon
the Lease Agreement shall be deemed prior to such deed of trust to the extent set forth in such document without regard to their respective dates of execution, delivery and/or recording. In that event, to the extent set forth in such document, such
deed of trust shall have the same rights with respect to this Lease Agreement as would have existed if this Lease Agreement had been executed, and a memorandum thereof, recorded prior to the execution, delivery and recording of the deed of trust.

  
 23 

 SEC. 25 TAX PROTEST: Tenant waives all rights under the Texas Property Tax Code, now or hereafter in
effect, including all rights under Sections 41.413 and 42.015 thereof, granting to tenants of real property or lessees of tangible personal property the right to protest the appraised value, or receive notice of reappraisal, of all or any part of
the Complex, irrespective of whether Landlord has elected to protest such appraised value. To the extent such waiver is prohibited, Tenant appoints Landlord as its attorney-in-fact, coupled with an interest, to appear and take all actions on behalf
of Tenant which Tenant may take under the Texas Property Tax Code. 
 SEC. 26 HOLDING OVER: In the event of holding over by Tenant with respect to
all or any portion of the Leased Premises after the expiration or termination of the Lease Agreement, such holding over shall constitute a tenancy at sufferance relationship between Landlord and Tenant and all of the terms and provisions of this
Lease Agreement shall be applicable during such period, except that as monthly rental, Tenant shall pay to Landlord for each month (or any portion thereof) during the period of such hold over an amount equal to one hundred fifty percent
(150%) of the Rent payable by Tenant for the month immediately preceding the holdover period. The rental payable during such hold over period shall be payable to Landlord on demand. No holding over by Tenant, whether with or without consent of
Landlord, shall operate to extend this Lease Agreement except as herein provided. In the event of any unauthorized holding over, Tenant shall also indemnify, defend (with counsel reasonably acceptable to Landlord) and hold harmless the Landlord
Parties (as defined on Exhibit I) against all claims for damages against the Landlord Parties as a result of Tenant’s possession of the Leased Premises, including, without limitation, claims for damages by any other party to which
Landlord may have leased, or entered into an agreement to lease, all or any part of the Leased Premises effective upon the termination of this Lease Agreement. Notwithstanding anything herein to the contrary, Landlord and Tenant specifically
agree that no notice to terminate Tenant’s tenancy hereunder will be required from and after the expiration of the Term of this Lease Agreement under Section 91.001 or Section 24.005 of the Texas Property Code before Landlord files a
forcible detainer suit on grounds that Tenant is holding over beyond the end of the Term or renewal period (if any) hereof; and any sublease hereunder shall not be approved unless it also contains a specific comparable waiver by the subtenant
thereunder. 
 SEC. 27 INDEPENDENT OBLIGATION TO PAY RENT: 

A. It is the intention of the parties hereto that the obligations of Landlord and Tenant hereunder shall be separate and independent covenants
and agreements, that the Rent and all other sums payable by Tenant hereunder shall continue to be payable in all events and that the obligations of Tenant hereunder shall continue unaffected, unless the requirement to pay or perform the same shall
have been terminated pursuant to an express provision of this Lease Agreement. 
 B. Except as otherwise expressly provided herein, Tenant
waives the right (a) to quit, terminate or surrender this Lease Agreement or the Leased Premises or any part thereof, or (b) to any abatement, suspension, deferment or reduction of the rent or any other sums payable under this Lease
Agreement. 
 SEC. 28 INDEMNITY; RELEASE AND WAIVER: 

A. Tenant hereby agrees to indemnify, protect, defend and hold the Landlord Parties harmless from and against any and all liabilities, claims,
causes of action, fines, damages, suits and expenses, including reasonable attorneys’ fees and necessary litigation expenses (collectively, the “Claims”), arising from Tenant’s use, occupancy or enjoyment of the Leased
Premises and its facilities for the conduct of its business or from any activity, work or thing done, permitted, omitted or suffered by Tenant and its partners, officers, directors, employees, agents, servants, contractors, customers, licensees and
invitees in or about the Complex, INCLUDING ANY CLAIMS RESULTING FROM THE NEGLIGENCE OF THE LANDLORD PARTIES, BUT NOT TO THE EXTENT 

  
 24 

 
CAUSED BY THE GROSS NEGLIGENCE OR WILLFUL MISCONDUCT OF THE LANDLORD PARTIES and Tenant further agrees to indemnify, protect, defend and hold the Landlord Parties harmless from and against
any and all Claims arising from any breach or default in the performance of any obligation on Tenant’s part to be performed under the terms of this Lease Agreement or arising from any negligence, or willful misconduct of Tenant or any of its
partners, officers, directors, employees, agents, servants, contractors, customers, licensees and invitees, INCLUDING ANY CLAIMS RESULTING FROM THE NEGLIGENCE OF THE LANDLORD PARTIES, BUT NOT TO THE EXTENT CAUSED BY THE GROSS NEGLIGENCE OR
WILLFUL MISCONDUCT OF THE LANDLORD PARTIES. In case any action or proceeding shall be brought against the Landlord Parties by reason of any such Claim, Tenant, upon notice from Landlord, shall provide a separate defense to same at Tenant’s
sole cost and expense by counsel reasonably satisfactory to Landlord. The indemnity obligations of Tenant under this Section 28.A shall survive the expiration or earlier termination of this Lease Agreement. 

B. Tenant hereby releases the Landlord Parties from any and all claims or causes of action whatsoever which Tenant might otherwise now or
hereafter possess resulting in or from or in any way associated with any loss covered or which would have been covered by insurance required to be carried by Tenant under this Lease Agreement, REGARDLESS OF CAUSE OR ORIGIN OF SUCH LOSS OR DAMAGE,
INCLUDING, WITHOUT LIMITATION, SOLE, JOINT, OR CONCURRENT NEGLIGENCE OF THE LANDLORD PARTIES, including the deductible and/or uninsured portion thereof, maintained and/or required to be maintained by Tenant pursuant to this Lease Agreement. 

C. Landlord shall not be liable or responsible to Tenant for (a) any loss or damage to any property or person occasioned by theft,
criminal act, fire, act of God, public enemy, injunction, riot, strike, insurrection, war, court order, requisition or order of governmental body or authority, or any cause beyond Landlord’s control, or (b) any damage or inconvenience
which may arise through repair or alteration of any part of the Building made necessary by virtue of any such cause; provided, however, Landlord shall use commercially reasonable efforts to minimize such damage or inconvenience to Tenant. 

D. Subject to Tenant’s indemnification obligations set forth in Section 28.A above, which shall not be limited, negated or lessened
in any way by the indemnity obligations set forth in this Section 28.D, Landlord hereby agrees to indemnify, protect, defend and hold the (a) Tenant, (b) its shareholders, members, partners, affiliates and subsidiaries, successors and
assigns, and (c) any directors, officers, employees, agents, or contractors of such persons or entities (collectively, the “Tenant Parties”) harmless from and against any and all Claims, arising from Landlord’s ownership
or operation of the Complex (excluding Claims arising from Tenant’s use, occupancy or enjoyment of the Leased Premises and Tenant’s use of the Parking Spaces) or from any activity, work or thing done, permitted or suffered by the Landlord
Parties in or about the Complex (excluding the Leased Premises and Tenant’ s Parking Spaces), EXCLUDING ANY PORTION OF ANY CLAIM TO THE EXTENT IT RESULTS FROM THE NEGLIGENCE, GROSS NEGLIGENCE OR WILLFUL MISCONDUCT OF THE TENANT PARTIES
and Landlord further agrees to indemnify, protect, defend and hold the Tenant Parties harmless from and against any and all Claims arising from any breach or default in the performance of any obligation on Landlord’s part to be performed under
the terms of this Lease Agreement or arising from any negligence or willful misconduct of the Landlord Parties, EXCLUDING ANY CLAIMS RESULTING FROM THE NEGLIGENCE, GROSS NEGLIGENCE OR WILLFUL MISCONDUCT OF THE TENANT PARTIES. In case any
action or proceeding shall be brought against the Tenant Parties by reason of any such Claim, Landlord, upon notice from Tenant, shall provide a separate defense to same at Landlord’s sole cost and expense by counsel reasonably satisfactory to
Tenant. The indemnity obligations of Landlord under this Section 28.D shall survive the expiration or earlier termination of this Lease Agreement. 

SEC. 29 INSURANCE: Landlord and Tenant shall satisfy the insurance requirements as more particularly described on Exhibit I attached
hereto and made a part hereof for all purposes. In no event shall Tenant’s liability under this Lease Agreement be limited by the amount of insurance required to be carried under Exhibit I. 

SEC. 30 ENTIRE AGREEMENT: This instrument and any attached addenda or exhibits signed by the parties constitute the entire agreement between Landlord
and Tenant with respect to the subject matter hereof; no prior written or prior or contemporaneous oral promises or representations shall be binding. This Lease Agreement shall not be amended, changed or extended except by written instrument signed
by both parties hereto. Section captions herein are for Landlord’s and Tenant’s convenience only, and neither limit nor amplify the provisions of this instrument. Tenant agrees, at Landlord’s request, to execute a recordable
memorandum of this Lease Agreement. 

  
 25 

 SEC. 31 NOTICES: Whenever in this Lease Agreement it shall be required or permitted that notice,
notification or demand be given or served by either party to this Lease Agreement to or on the other, such notice or demand shall be given or served and shall not be deemed to have been given or served unless in writing and (i) delivered
personally, (ii) forwarded by facsimile, (iii) sent by Certified or Registered Mail, postage prepaid, with a copy also sent by facsimile or (iv) sent by a reputable common carrier guaranteeing next-day delivery, addressed as follows:

  

			
	To the Landlord:	  	Sheridan Hills Developments L.P.
		  	c/o The Metrontario Group
		  	601-1 Yorkdale Road
		  	Toronto, Ontario
		  	Canada M6A 3A1
		  	Attention: Mr. Matt Fisher
		  	Telephone: (416) 785-6000x228
		  	Facsimile: (416) 785-7000
		
	With a copy to:	  	Andrews Kurth LLP
		  	600 Travis, Suite 4200
		  	Houston, TX 77002
		  	Attn: Darren S. Inoff, Esq.
		  	Telephone: (713) 220-3841
		  	Facsimile: (713) 238-7134
		
	With a copy to:	  	Jones Lang LaSalle
		  	Americas, Inc.
		  	1400 Post Oak Boulevard, Suite 1100
		  	Houston, Texas 77056
		  	Attention: Mary Stanton
		  	Telephone: (713) 888-4009
		  	Facsimile: (713) 888-4040
		
	With a copy to:	  	Property Management Office
		  	2301 West Holcombe Blvd., Suite 1300
		  	Houston, Texas 77030
		  	Attention: Property Manager
		  	Telephone: (713) 592-5433
		  	Facsimile: (713) 660-0295
		
	To the Tenant:	  	At the address noted for Tenant on the signature page hereof until the Commencement Date, at which time it shall become the Address of the Leased Premises.
		
	With a copy to:	  	DuBois, Bryant & Campbell, LLP
		  	700 Lavaca, Suite 1300
		  	Austin, Texas 78701
		  	Attention: Kim Shraibati
		  	Telephone: (512) 457-8000
		  	Facsimile: (512) 457-8008

 Such addresses may be changed from time to time by either party by serving written notice as above provided. Any such notice
or demand shall be deemed to have been given on the date of receipted delivery, refusal to accept delivery or when delivery is first attempted but cannot be made due to a change of address for which no notice is given, five (5) business days
after it shall have been mailed as provided in this Section 31 or if sent by facsimile, upon electronic or telephonic confirmation of receipt from the receiving facsimile machine, whichever is earlier. 

  
 26 

 SEC. 32 COMMENCEMENT DATE: Tenant shall, if requested by Landlord, execute and deliver to Landlord within
ten (10) days of Landlord’s request an Acceptance of Premises Memorandum of the Leased Premises, the form of which is attached as Exhibit E attached hereto and made a part hereof for all purposes. 

SEC. 33 INTENTIONALLY DELETED: 
 SEC. 34 BROKERS:
Each of Landlord and Tenant warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of this Lease Agreement, excepting only PinPoint Commercial, L.P. and Cushman & Wakefield of Texas,
Inc. (“Broker”) and that it knows of no other real estate broker(s) or agent(s) who is(are) or might be entitled to a commission in connection with this Lease Agreement. Landlord shall agree to pay all real estate commissions due in
connection with this Lease Agreement only to the broker(s) named herein, provided Landlord and such broker have entered into a separate commission agreement. Tenant agrees to indemnify, defend (with counsel reasonably acceptable to Landlord) and
hold harmless the Landlord Parties from and against any liability from all other claims for commissions, finder’s fee or other compensation arising from the negotiation of this Lease Agreement on Tenant’s behalf. Landlord agrees to
indemnify, defend (with counsel reasonably acceptable to Tenant) and hold Tenant harmless from and against any liability from all other claims for commissions, finder’s fee or other compensation arising from the negotiation of this Lease
Agreement on Landlord’s behalf. 
 SEC. 35 ESTOPPEL CERTIFICATES: From time to time after the Effective Date, within ten (10) days after
request in writing therefor from Landlord, Tenant agrees to execute and deliver to Landlord, or to such other addressee or addresses as Landlord may designate (and Landlord and any such addressee may rely thereon), a statement in writing in the form
of Exhibit F attached hereto and made a part hereof for all purposes or in such other form and substance satisfactory to Landlord (herein called “Tenant’s Estoppel Certificate”), certifying to all or any part of
the information provided for in Exhibit F as is requested by Landlord and any other information reasonably requested by Landlord. 
 SEC.
36 NAME CHANGE: Landlord and Tenant mutually covenant and agree that Landlord hereby reserves and shall have the right at any time and from time to time to change the name of the Building or the address of the Building as Landlord may deem
advisable, and Landlord shall not incur any liability whatsoever to Tenant as a consequence thereof. 
 SEC. 37 BANKRUPTCY: If a petition is filed by
or against Tenant for relief under Title 11 of the United States Code, as amended (the “Bankruptcy Code”), and Tenant (including for purposes of this Section Tenant’s successor in bankruptcy, whether a trustee or Tenant as
debtor in possession) assumes and proposes to assign, or proposes to assume and assign, this Lease Agreement pursuant to the provisions of the Bankruptcy Code to any person or entity who has made or accepted a bona fide offer to accept an assignment
of this Lease Agreement on terms acceptable to Tenant, then notice of the proposed assignment setting forth (a) the name and address of the proposed assignee, (b) all of the terms and conditions of the offer and proposed assignment, and
(c) the adequate assurance to be furnished by the proposed assignee of its future performance under the Lease Agreement, shall be given to Landlord by Tenant no later than twenty (20) days after Tenant has made or received such offer, but
in no event later than ten (10) days prior to the date on which Tenant applies to a court of competent jurisdiction for authority and approval to enter into the proposed assignment. Landlord shall have the prior right and option, to be
exercised by notice to Tenant given at any time prior to the date on which the court order authorizing such assignment becomes final and non-appealable, to receive an assignment of this Lease Agreement upon the same terms and conditions, and for the
same consideration, if any, as the proposed assignee, less any brokerage commissions which may otherwise be payable out of the consideration to be paid by the proposed assignee for the assignment of this Lease Agreement. If this Lease Agreement is
assigned pursuant to the provisions of the Bankruptcy Code, Landlord: (i) may require from the assignee a deposit or other security for the performance of its obligations under the Lease Agreement in an amount substantially the same as would
have been required by Landlord upon the initial leasing to a tenant similar to the assignee; and (ii) shall receive, as additional rent, the sums and economic consideration described in Section 12.A(3)(e). Any person or entity to which
this Lease Agreement is assigned pursuant to the provisions of the Bankruptcy Code shall be deemed, without further act or documentation, to have assumed all of the Tenant’s obligations arising under this Lease Agreement on and after the date
of such assignment. Any such assignee shall, upon demand, execute and deliver to Landlord an instrument confirming such assumption. No provision of this Lease Agreement shall be deemed a waiver of Landlord’s rights or remedies under the
Bankruptcy Code to oppose 

  
 27 

 
any assumption and/or assignment of this Lease Agreement, to require a timely performance of Tenant’s obligations under this Lease Agreement, or to regain possession of the Leased Premises
if this Lease Agreement has neither been assumed or rejected within sixty (60) days after the date of the order for relief or within such additional time as a court of competent jurisdiction may have fixed. Notwithstanding anything in this
Lease Agreement to the contrary, all amounts payable by Tenant to or on behalf of Landlord under this Lease Agreement, whether or not expressly denominated as rent, shall constitute rent for the purposes of Section 502(b)(6) of the Bankruptcy
Code. 
 SEC. 38 TELECOMMUNICATIONS PROVIDERS: In the event Tenant wishes to use, at anytime during the Term of this Lease Agreement, the services of
a telecommunications provider whose equipment or service is not then in the Building, no such provider shall be entitled to enter the Building or commence providing such service without first obtaining the prior written consent of Landlord, which
consent shall not be unreasonably withheld, conditioned or delayed. Landlord may condition its consent on such matters as Landlord reasonably deems appropriate including, without limitation, (i) such provider agreeing to an easement or license
agreement in form and substance reasonably satisfactory to Landlord, (ii) Landlord having been provided and approved the plans and specifications for the equipment to be installed in the Building, (iii) Landlord having received, prior to
the commencement of such work, such indemnities, bonds or other financial assurances as Landlord may require, (iv) the provider agreeing to abide by all Building rules and regulations, and agreeing to provide Landlord an “as built”
set of plans and specifications, (v) the provider agreeing to pay Landlord such compensation as Landlord determines to be reasonable, and (vi) Landlord having determined that there is adequate space in the Building for the placement of all
of such provider’s lines and equipment. 
 SEC. 39 HAZARDOUS SUBSTANCES: 

A. Tenant shall not cause or permit any Hazardous Substance (as hereinafter defined) to be used, stored, generated, contained or disposed of
on or in the Complex by Tenant, Tenant’s agents, employees, contractors or invitees in violation of Environmental Laws (as hereinafter defined). Landlord acknowledges and agrees that as part of Tenant’s use of the Leased Premises as a
research laboratory, Tenant shall be permitted to use lab alcohols, acids, radioactive agents, liquid nitrogen (including installation of liquid nitrogen freezers) and other related medical research items as are necessary to the operation of a
research laboratory up to and including Biosafety Level 2, provided Tenant must use and store such materials in compliance with all applicable laws, rules and regulations, including, without limitation, all Environmental Laws. All bio-hazardous
waste shall be removed, at Tenant’s sole cost and expense, and at Tenant’s risk, by a third party company following any and all Environmental Laws, insurance requirements and industry disposal regulations regarding said waste. If Hazardous
Substances are used, stored, generated, contained or disposed of on or in the Complex in violation of Environmental Laws, or if the Complex becomes contaminated with Hazardous Substances in any manner due to the actions or omissions of Tenant or its
agents, employees, contractors or invitees, Tenant shall indemnify, defend (with counsel reasonably acceptable to Landlord) and hold the Landlord Parties harmless from any and all claims, damages, fines, judgments, penalties, costs, liabilities and
losses (including, without limitation, a decrease in value of the Complex, damages caused by loss or restriction of rentable or usable space or any damages caused by adverse impact on marketing of the space and any and all sums paid for settlement
of claims, attorneys’ fees, consultant and expert fees) arising during or after the Term and as a result of such use, storage, generation, disposal or contamination in violation of Environmental Laws. This indemnification includes, without
limitation, any and all costs incurred because of any investigation of the site or any cleanup, removal or restoration mandated by a federal, state or local agency or political subdivision. Without limitation of the foregoing, if Tenant causes or
permits the presence of any Hazardous Substance on the Complex in violation of Environmental Laws that results in contamination, Tenant shall promptly, at its sole expense, take any and all necessary actions to return the Complex to the condition
existing prior to the presence of any such Hazardous Substance on the Complex; provided, however, Tenant must obtain Landlord’s prior written approval for any such remedial action. Tenant shall be responsible for the application for and
maintenance of all required permits, the submittal of all notices and reports, proper labeling, training and record keeping, and timely and appropriate response to any release or other discharge by Tenant of a Hazardous Substance under Environmental
Laws. The indemnity obligations of Tenant under this Section 39 shall survive the expiration or earlier termination of this Lease Agreement. Notwithstanding the foregoing to the contrary, Tenant acknowledges that the Building will be used by
various tenants for medical-related purposes and as such, certain Hazardous Substances will be present in the Complex from time to time. To Landlord’s current actual knowledge, without the duty of investigation or injury, as of the Effective
Date, no Hazardous Substances are in, on, under or about the Leased Premises in violation of any Environmental Law, or requiring any notice, investigation, clean-up, 

  
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or other response and Landlord shall indemnify, defend (with counsel reasonably acceptable to Tenant) and hold the Tenant and its officers, directors, agents and employees harmless from any and
all claims, damages, fines, judgments, penalties, costs, liabilities and losses arising during or after the Term as a result of Landlord’s breach of such representation and warranty. Landlord’s obligations set forth in this Section 39
shall survive the expiration or termination of this Lease Agreement. 
 B. As used herein, “Hazardous Substance” means
(i) any substance that is toxic, ignitable, reactive or corrosive or that is regulated by any local, state or federal law, and includes any and all material or substances that are defined as “hazardous waste”, “extremely
hazardous waste”, “hazardous substance” or a “hazardous material” pursuant to any such laws and includes, but is not limited to, asbestos, polychlorobiphenyls and petroleum and any fractions thereof, (ii) any substance
which is now or hereafter considered a biological contaminant or which could adversely impact air quality, including mold, fungi and other bacterial agents and (iii) all biohazardous, infectious and medical waste. Notwithstanding anything in
this Section 39 to the contrary, “Hazardous Substances” shall not include materials commonly used in the ordinary operations of a general office building, provided that (1) such materials are used and properly stored in the
Leased Premises in quantities ordinarily used and stored in comparable medical space, (2) such materials are not introduced into the Building’s plumbing systems or are not otherwise released or discharged in the Leased Premises or the
Building and (3) such materials are in strict compliance with local, state or federal law. As used herein, “Environmental Laws” means all applicable federal, state or local laws, regulations, orders, judgments and decrees
regarding health, safety or the environment. 
 SEC. 40 NO MONEY DAMAGES FOR FAILURE TO CONSENT; WAIVER OF CERTAIN DAMAGES: Wherever in this Lease
Agreement Landlord’s consent or approval is required, if Landlord refuses to grant such consent or approval, whether or not Landlord expressly agreed that such consent or approval would not be unreasonably withheld, conditioned or delayed,
Tenant shall not make, and Tenant hereby waives, any claim for money damages (including any claim by way of set-off, counterclaim or defense) based upon Tenant’s claim or assertion that Landlord unreasonably withheld, conditioned or delayed its
consent or approval. Tenant’s sole remedy shall be an action or proceeding to enforce such provision, by specific performance, injunction or declaratory judgment. Except as otherwise permitted by Section 26 of this Lease Agreement, IN
NO EVENT SHALL THE EITHER PARTY HERETO BE LIABLE FOR, AND EACH PARTY HEREBY WAIVES ANY CLAIM FOR, ANY INDIRECT, CONSEQUENTIAL, EXEMPLARY OR PUNITIVE DAMAGES, INCLUDING LOSS OF PROFITS OR BUSINESS OPPORTUNITY, ARISING UNDER OR IN CONNECTION WITH THIS
LEASE AGREEMENT. 
 SEC. 41 ACKNOWLEDGMENT OF NON-APPLICABILITY OF DTPA: It is the understanding and intention of the parties that Tenant’s
rights and remedies with respect to the transactions provided for and contemplated in this Lease Agreement (collectively, this “Transaction”) and with respect to all acts or practices of Landlord, past, present or future, in
connection with this Transaction, are and shall be governed by legal principles other than the Texas Deceptive Trade Practices - Consumer Protection Act (the “DTPA”). Accordingly, Tenant hereby (a) agrees that under
Section 17.49(f) of the DTPA this Transaction is not governed by the DTPA and (b) certifies, represents and warrants to Landlord that (i) Tenant has been represented by legal counsel in connection with this Transaction who has not
been directly or indirectly identified, suggested or selected by the Landlord and Tenant has conferred with Tenant’s counsel concerning all elements of this Lease Agreement (including, without limitation, this Section 41) and this
Transaction and (ii) the Leased Premises will not be occupied by Tenant as Tenant’s family residence. Tenant expressly recognizes that the total consideration as agreed to by Landlord has been predicated upon the inapplicability of the
DTPA to this Transaction and that Landlord, in determining to proceed with the entering into of this Lease Agreement, has expressly relied on the inapplicability of the DTPA to this Transaction. 

SEC. 42 ATTORNEYS’ FEES: In the event either party defaults in the performance of any of the terms, agreements or conditions contained in this
Lease Agreement and the other party places the enforcement of this Lease Agreement, or any part thereof, or the collection of any rent due or to become due hereunder, or recovery of the possession of the Leased Premises, in the hands of an attorney
who files suit upon the same, and should such non-defaulting party prevail in such suit, the defaulting party agrees to pay the other party’s reasonable attorneys’ fees and other disbursements or costs thereby incurred. 

SEC. 43 AUTHORITY OF TENANT: If Tenant is a corporation, partnership or other entity, Tenant warrants and represents unto Landlord that (a) Tenant
is a duly organized and existing legal entity, in good standing in the State of 

  
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Texas, (b) Tenant has full right and authority to execute, deliver and perform this Lease Agreement, (c) the person executing this Lease Agreement was authorized to do so and
(d) upon written request of Landlord, such person will deliver to Landlord satisfactory evidence of his or her authority to execute this Lease Agreement on behalf of Tenant. 

SEC. 44 INABILITY TO PERFORM: Whenever a period of time is prescribed for the taking of an action by Landlord or Tenant, the period of time for the
performance of such action shall be extended by the number of days or months that the performance is actually delayed due to strikes, acts of God, shortages of labor or materials, war, terrorist attacks (including bio-chemical attacks), civil
disturbances and other causes beyond the reasonable control of the Landlord or Tenant, as the case may be (“Force Majeure”); provided, however, Force Majeure shall not excuse Tenant’s obligation to pay any sums of money due
hereunder, including without limitation, the obligation to pay Rent. 
 SEC. 45 JOINT AND SEVERAL TENANCY: If more than one person executes this
Lease Agreement as Tenant, their obligations hereunder are joint and several, and any act or notice of or to, or refund to, or the signature of any one or more of them, in relation to the renewal or termination of this Lease Agreement, or under or
with respect to any of the terms hereof shall be fully binding on each and all of the persons executing this Lease Agreement as a Tenant. 
 SEC. 46
EXECUTION OF THIS LEASE AGREEMENT: The submission of an unsigned copy of this Lease Agreement to Tenant for Tenant’s consideration does not constitute an offer to lease the Leased Premises or an option to or for the Leased Premises. This
Lease Agreement shall become effective and binding only upon the execution and delivery of this Lease Agreement by both Landlord and Tenant. 
 SEC. 47
WAIVER OF TRIAL BY JURY; COUNTERCLAIM: LANDLORD AND TENANT HEREBY WAIVE TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM BROUGHT BY EITHER PARTY AGAINST THE OTHER ON ANY MATTERS IN ANY WAY ARISING OUT OF OR CONNECTED WITH THIS LEASE
AGREEMENT, THE RELATIONSHIP OF LANDLORD AND TENANT, TENANT’S USE OR OCCUPANCY OF THE LEASED PREMISES, OR THE ENFORCEMENT OF ANY REMEDY UNDER ANY APPLICABLE LAW, RULE, STATUTE, ORDER, CODE OR ORDINANCE. If Landlord commences any legal proceeding
against Tenant, Tenant shall not interpose any counterclaim of any nature or description in any such proceeding (unless failure to impose such counterclaim would preclude Tenant from asserting in a separate action the claim which is the subject of
the counterclaim), and will not seek to consolidate any such proceeding with any other action which may have been or will be brought in any other court by Tenant. 

SEC. 48 CALCULATION OF TIME PERIODS: Should the calculation of any of the various time periods provided for herein result in an obligation becoming due
on a Saturday, Sunday or legal holiday (such day which is neither Saturday, Sunday or legal holiday, a “business day”), then the due date of such obligation or scheduled time of occurrence of such event shall be delayed until the next
business day. 
 SEC. 49 ANTI-TERRORISM LAWS: Tenant represents and warrants to and covenants with Landlord that (i) neither Tenant nor any of
its owners or affiliates currently are, or shall be at any time during the Term, in violation of any laws relating to terrorism or money laundering (collectively, the “Anti-Terrorism Laws”), including without limitation Executive
Order No. 13224 on Terrorist Financing, effective September 24, 2001, and regulations of the U.S. Treasury Department’s Office of Foreign Assets Control (OFAC) related to Specially Designated Nationals and Blocked Persons (SDN’s
OFAC Regulations), and/or the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001 (Public Law 107-56) (the “USA Patriot Act”); (ii) neither Tenant nor any of
its owners, affiliates, investors, officers, directors, employees, vendors, subcontractors or agents is or shall be during the term hereof a “Prohibited Person” which is defined as follows: (1) a person or entity owned or
controlled by, affiliated with, or acting for or on behalf of, any person or entity that is identified as a Specially Designated National and Blocked Person on the then-most current list published by OFAC at its official website, h
http;//www.treas.gov/offices/eotffc/ofac/sdn/t 11 sdn.pdf, or at any replacement website or other replacement official publication of such list, and (2) a person or entity who is identified as or affiliated with a person or entity
designated as a terrorist, or associated with terrorism or money laundering pursuant to regulations promulgated in connection with the USA Patriot Act; and (iii) Tenant has taken appropriate steps to understand its legal obligations under the
Anti-Terrorism Laws and has implemented appropriate procedures to assure its continued 

  
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compliance with such laws. Tenant hereby agrees to defend, indemnify, and hold harmless Landlord, its officers, directors, agents and employees, from and against any and all claims, damages,
losses, risks, liabilities and expenses (including attorney’s fees and costs) arising from or related to any breach of the foregoing representations, warranties and covenants. At any time and from time-to-time during the Term, Tenant shall
deliver to Landlord within ten (10) days after receipt of a written request therefor, a written certification or such other evidence reasonably acceptable to Landlord evidencing and confirming Tenant’s compliance with this Section 49.

 SEC. 50 RENEWAL OPTIONS: Tenant shall have, and is hereby granted, the options (the “Renewal Options”) to extend the Term of this
Lease Agreement for five (5) additional periods of one (1) year each (as applicable, the “Extended Term”) upon and subject to the following terms, conditions and provisions: 

A. The Renewal Options may only be exercised by Tenant giving irrevocable written notice thereof to Landlord no later than nine
(9) months and one (1) day prior to the commencement of the Extended Term arising from the Renewal Option being exercised. If Tenant fails to give Landlord such written notice of exercise of such Renewal Option within such specified time
period, Tenant shall be deemed to have elected not to exercise, and to have waived, such Renewal Option and the unexercised Renewal Options shall automatically terminate and expire and be of no further force and effect. It is expressly agreed that
Tenant shall not have the option to extend the Term of this Lease Agreement beyond the Extended Term. If Tenant exercises any of the Renewal Options, such Extended Term shall commence immediately upon the expiration of the then current Term of this
Lease Agreement (as applicable, the “Extended Term Commencement Date”). 
 B. If Tenant exercises any of the Renewal
Options (in accordance with and subject to the provisions of this Section 50), the Extended Term shall be upon, and subject to, all of the terms, covenants and conditions provided in this Lease Agreement except for any terms, covenants and
conditions that are expressly or by their nature inapplicable to the Extended Term (including, without limitation, the right to renew the Term of this Lease Agreement beyond the final Extended Term) and except that (i) the annual Base Rent
during the applicable Extended Term shall increase $0.50 per square foot of Net Rentable Area in the Leased Premises in each year of the Extended Term over the Base Rent in effect at the expiration of the previous year and (ii) the Leased
Premises and all leasehold improvements relating thereto will be provided in the condition they exist (i.e., “AS IS” and “WITH ALL FAULTS”) on the Extended Term Commencement Date, and this Lease Agreement shall be deemed to have
been automatically amended as of the Extended Term Commencement Date in accordance with this Section 50. Tenant and Landlord shall promptly (but in no event longer than fifteen (15) days after Landlord’s submission of the amendment to
Tenant) execute and deliver an appropriate amendment of this Lease Agreement to evidence such terms as will apply following commencement of the Extended Term. 

C. Notwithstanding any provision herein to the contrary, Tenant shall not have the right to extend the Term of this Lease Agreement pursuant
to this Section 50 and such right shall automatically terminate and be of no further force and effect if, at the time Tenant exercises such Renewal Option or on the Extended Term Commencement Date, an Event of Default then exists under this
Lease Agreement. Tenant shall not have the right to assign the Renewal Options to any sublessee or assignee of the Leased Premises other than a Permitted Transferee, nor may any such sublessee or assignee (other than a Permitted Transferee) exercise
the Renewal Options unless in connection with an assignment of Tenant’s entire interest in this Lease Agreement or a sublease of the entire Leased Premises. 

D. For all purposes under this Lease Agreement, the Extended Term (if exercised) shall be deemed to be included in and part of the Term. 

SEC. 51 RIGHT OF FIRST REFUSAL: 
 A.
Subject only to the renewal options, expansion options, rights of first offer and rights of first refusal of other tenants in the Building granted by Landlord prior to the Effective Date (as listed on Exhibit L attached hereto and made
a part hereof for all purposes) or which are included in any lease executed after the Effective Date as to which Tenant failed or elected not to exercise its right of refusal under this Section 51, Tenant shall have a continuing right of first
refusal (the “Right of First Refusal”) during the Term with respect to any available space in the Building that is located on the eighth (8th) floor of the Building
(“ROFR Space”); provided, however, if a Lease Offer (as hereinafter defined) includes the ROFR Space plus any other space in the Building 

  
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(the “Excess Space”) and Landlord gives Tenant the option to lease the Excess Space in addition to the ROFR Space, all as more particularly described in an Availability Notice
(as hereinafter defined), then Tenant must also lease such Excess Space in order to exercise the Right of First Refusal granted herein. 

B. In the event Landlord desires to accept an offer to lease any of the ROFR Space from any third party (a “Lease Offer”), as
evidenced by a term sheet or letter of intent, signed by the third-party prospect (subject to any confidentiality requirements of such third-party prospect prohibiting disclosure of its name), Landlord shall give Tenant written notice thereof (the
“Availability Notice”), which notice shall include the Lease Offer. If such Availability Notice is delivered to Tenant, Tenant shall have three (3) business days from the date of receipt of the Availability Notice to either
(i) irrevocably elect to lease said space under the Terms of the Lease Offer, by delivering written notice thereof (the “Election Notice”) to Landlord within such three (3) business day period, or (ii) notify Landlord that
it does not desire to lease said space. In the event Tenant (i) notifies Landlord that it does not desire to lease said space or (ii) fails to deliver the Election Notice to Landlord within said three (3) business day period, Tenant
shall be deemed to have elected not to lease said space, and Landlord shall have a period of one hundred eighty (180) days thereafter to lease such ROFR Space to such third-party tenant prospect upon the terms set forth in the Availability
Notice, except that (i) the space actually leased may be greater or up to ten percent (10%) smaller than that set forth in the Lease Offer, and (ii) the lease may be different from the Lease Offer in other immaterial respects. If
Landlord does not enter into such a lease of such ROFR Space with such third-party tenant prospect within said one hundred eighty (180) day period, or if Landlord desires to enter into a lease of the ROFR Space with another party or with such
third-party tenant prospect in which (i) the space actually leased is more than ten percent (10%) smaller than the square footage specified in the Availability Notice or (ii) the lease terms vary in respects that are material (such as
the addition of an early termination provision) or decrease the rent per square foot or other economic obligations of the tenant reflected in the Lease Offer, Tenant shall again have a right of refusal on such ROFR Space as set forth in this Section
51. 
 C. If Tenant exercises a Right of First Refusal, then effective as of the date that is the earlier to occur of (1) the date
Tenant occupies all or any portion of the ROFR Space for the purpose of conducting its business therein, or (2) sixty (60) days following the date Landlord delivers possession of the ROFR Space to Tenant (the “ROFR Space Delivery
Date”), such ROFR Space shall become a part of the Leased Premises, the annual Additional Rent and Base Rent per square foot of Net Rentable Area for such ROFR Space shall be equal to the Additional Rent and Base Rent stated in the Lease
Offer, and such ROFR Space shall be subject to all of the terms, provisions and conditions of the Lease Offer and this Lease Agreement, other than any terms, covenants and conditions that are expressly or by their nature inapplicable to such ROFR
Space, except that (i) Base Rent and Tenant’s Additional Rent with respect to such ROFR Space shall commence to accrue on the earlier to occur of (1) the date Tenant occupies all or any portion of such ROFR Space for the purpose of
conducting its business therein, or (2) sixty (60) days after Landlord’s delivery of the ROFR Space to Tenant, (ii) such ROFR Space and any and all leasehold improvements therein will be provided in the condition they exist
(i.e. “AS IS” and “WITH ALL FAULTS”) on such delivery date; and (iii) the Term of this Lease Agreement insofar as it relates to such ROFR Space shall be equal to the longer of (1) the Term with respect to the
Leased Premises or (2) the term set forth in the Availability Notice. Notwithstanding any provision to the contrary in this Lease Agreement, if the term set forth in the Availability Notice is longer than the Term with respect to the Leased
Premises, Tenant may elect to extend the Term of the Leased Premises to be coterminous with the term set forth in the Availability Notice, in which event the extended term for the Leased Premises shall be on the terms which would otherwise apply to
a Renewal Option as set forth in Section 50, except that the Base Rent per square foot shall be the greater of the Base Rent that would be payable upon the exercise of a Renewal Option and the Base Rent set forth in the Availability Notice.
This Lease Agreement shall be deemed to have been automatically amended in accordance with this Section 51.0 as of the date of the Election Notice, and Tenant and Landlord shall thereafter promptly (but in no event longer than fifteen
(15) days after Landlord’s submission of the amendment to Tenant) execute and deliver an appropriate amendment of this Lease Agreement to evidence the foregoing. 

D. Notwithstanding any provision herein to the contrary, Tenant shall not have the right to lease the ROFR Space pursuant to this
Section 51 if, at the time Tenant exercises such Right of First Refusal or on the applicable ROFR Space Delivery Date, an Event of Default then exists under this Lease Agreement. Any termination of this Lease Agreement shall also terminate the
Right of First Refusal. Tenant shall not have the right to assign the Right of First Refusal to any subtenant of the Leased Premises or assignee of this Lease Agreement other than a Permitted Transferee, nor may any such subtenant or assignee (other
than a Permitted Transferee) exercise such Right of First Refusal unless in connection with an assignment of Tenant’s entire interest in this Lease Agreement or a sublease of the entire Leased Premises. 

  
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 SEC. 52 PREFERENTIAL RIGHT TO LEASE: 

A. Subject only to the renewal options, expansion options, rights of first offer and rights of first refusal of other tenants in the Building
granted by Landlord prior to the Effective Date (as listed on Exhibit L attached hereto and made a part hereof for all purposes) or which are included in any lease executed after the Effective Date as to which Tenant failed or elected
not to exercise its Right of First Refusal under Section 51, and provided no less than twenty-four (24) months remain in the then-remaining Term, including any Extended Term or Terms created through Renewal Options exercised previously or
contemporaneously, Tenant shall have a continuing and recurring right, more specifically described below, to lease any space which shall be or become available for “direct” lease on the eighth (8th) floor of the Building (the
“Preferential Right to Lease”). The Preferential Right to Lease is not a “right of first offer”, but rather (absent a prospect for the space, as to which the Right of First Refusal provisions shall apply) the right on the
part of Tenant to give written notice to Landlord of its desire to lease additional space on the eighth (8th) floor of the Building (a “Tenant’s Preferential Notice”), which shall include (i) the approximate amount of
additional space which Tenant desires to lease, and (ii) the desired commencement date for such space, it being understood and agreed that the term of the lease for such additional space shall be coterminous with the then existing Term. Within
ten (10) business days of receipt of Tenant’s Preferential Notice, Landlord shall give written notice to Tenant of (a) all such space availabilities on the eighth (8th) floor of the Building (including space that Landlord
believes may become available during the six (6) month period before and after Tenant’s date of desired commencement) (the “Available Space”), (b) an existing-condition floor plan(s) of the Available Space, and
(c) the applicable leasehold improvement allowance (a “Landlord’s Preferential Right Notice”). Space for which Landlord has a lease proposal out, or is actively negotiating a letter of intent, lease or similar agreement
with a third party, shall not be deemed “Available Space”. Within ten (10) business days of receipt of Landlord’s Preferential Right Notice, Tenant shall give Landlord written notice of its intent to lease all or a portion
(contiguous to the Leased Premises as they are then constituted) of the Available Space. The lease of such Available Space shall be on the same terms and conditions as the initial Leased Premises (including the termination date, the Rent then
applicable under this Lease Agreement and the dates of rental increases); provided, however, Tenant will be only be provided with a leasehold improvement allowance for such Available Space equal to the product of (x) $45.00 per square foot of
Net Rentable Area in the Available Space and (y) a quotient, the numerator of which is the number of months in the initial Term remaining from the commencement date for such Available Space and the denominator of which is the number of months
in the initial Term), and the Term with respect to such Available Space shall commence on the date which is the earlier to occur of (A) Tenant’s beneficial occupancy of the space for the purposes of conducting its business therein, or
(B) sixty (60) days after Landlord tenders such space in its entirety to Tenant. If any of the Available Space which Tenant intends to lease is occupied by a tenant whose lease is expiring, then notwithstanding anything herein contained,
Landlord shall be entitled to accept an offer from, or make an offer to, the existing tenant to extend its lease on such terms as Landlord considers appropriate, and in the event that the said tenant and Landlord agree on the terms of an extension,
Tenant’s notice of intent to lease such Available Space shall be of no force or effect, and Tenant shall be entitled to revoke its notice in respect of the other Available Space it intended to lease. If Tenant elects to lease only a portion of
the Available Space on a given floor, then the location and configuration of the space which Tenant desires to lease must be reasonably acceptable to Landlord, including as to the marketability of the remaining space on the floor. 

B. This Lease Agreement shall be deemed to have been automatically amended in accordance with this Section 52 as of the date the
Available Space is delivered to Tenant, and Tenant and Landlord shall thereafter promptly (but in no event longer than fifteen (15) days after Landlord’s submission of the amendment to Tenant) execute and deliver an appropriate amendment
of this Lease Agreement to evidence the foregoing. Notwithstanding any provision herein to the contrary, Tenant shall not have the right to lease the Available Space pursuant to this Section 52 if, at the time Tenant exercises its right to
lease such Available Space, an Event of Default then exists under this Lease Agreement. Any termination of this Lease Agreement shall also terminate the Preferential Right to Lease. Tenant shall not have the right to assign the Preferential Right to
Lease to any subtenant of the Leased Premises or assignee of this Lease Agreement other than a Permitted Transferee, nor may any such subtenant or assignee (other than a Permitted Transferee) exercise such Preferential Right to Lease unless in
connection with an assignment of Tenant’s entire interest in this Lease Agreement or a sublease of the entire Leased Premises. 
 C.
Subject to the requirements of prospective tenants, any leasing done by Landlord on the eighth (8th) floor of the Building shall begin at the northeast corner of the floor and progress first
in a southerly direction, and then in a westerly direction. 

  
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 SEC. 53 CHASE SPACE: At no cost to Tenant for such right during the Term, Tenant shall have the right to
use (on a non-exclusive basis), its pro rata share (based on the percentage of the total Net Rentable Area of the Building comprising the Leased Premises) of the chase space located either (i) on the south side of the Building towards the
southwest corner of the 8th floor, or (ii) the chase space located in the core of the Building, such chase space to be used solely by Tenant for uses associated with the laboratory in the Leased Premises (such as venting of a fume hood), which
uses shall be subject to the prior written approval of the Landlord. In the event Tenant needs to penetrate surfaces within the Building for such installations, immediately after the completion of such work, Tenant will conceal such work and/or the
surface finish will be returned to its condition at the time Tenant commenced such work. All such work will be at Tenant’s sole cost and expense and be subject to Landlord’s prior approval as to location, time, manner and nature of such
work and such work must comply with the terms and provisions of this Lease Agreement. 
 SEC. 54 BACK-UP GENERATOR: 

A. Tenant shall be permitted, at its sole cost and expense, to install, connect to the Building, operate and maintain a diesel back-up
electrical generator and all related equipment switching gear, conduit and equipment mounts (collectively, “Generator”) screened from public view to be located in a location in the Complex mutually agreed upon by Landlord and
Tenant. The installation of the Generator shall be subject to all conditions and requirements as provided for in Section 10 hereof. Landlord reserves the right to relocate the Generator from time to time at Landlord’s cost and expense, and
to install its own generator providing back-up power to the Common Areas and emergency lighting in the Complex in the same area as Tenant’s Generator. 

B. The installation, maintenance, repair, replacement, removal and repair of any damage relating to the Generator, and all related costs,
shall be the sole responsibility of Tenant, subject to Landlord’s reasonable direction and control. Landlord shall supply diesel fuel for the Generator from the central tank at the Building which the Landlord shall maintain at its sole cost and
expense, but with the diesel fuel drawn from same by Tenant to be at Tenant’s sole cost and expense based on a meter (also to be installed and maintained at Tenant’s sole cost and expense). Notwithstanding anything to the contrary
contained herein, in no event shall Tenant be permitted to install or maintain on or about the Leased Premises or the Building any underground fuel storage tanks or any diesel fuel tanks of its own. 

C. Upon the expiration or termination of this Lease Agreement, or at such time as Tenant decides that it no longer wishes to maintain the
Generator, Tenant shall be obligated to remove the Generator and all related or ancillary equipment, wiring, and the like, and Tenant shall repair any damage caused by the installation and use of the Generator and by such removal in a manner and
method reasonably satisfactory to Landlord. 
 D. The Generator shall be used solely for the generation of emergency power in the event of
and only for the duration of a power outage or “brownout”, or interruption of electrical service to the Building. Tenant shall be permitted to periodically test the Generator to confirm that it is in good working order. The Generator shall
be used solely for purposes of Tenant’s business in the Leased Premises. The use and operation of the Generator shall comply with all applicable provisions of this Lease Agreement. In no event shall the maintenance, use and operation of the
Generator interfere with any of the systems of the Building. Tenant shall comply with all laws applicable to the use and operation of the Generator. Tenant shall be responsible for obtaining all licenses, permits and approvals for the use and
operation of the Generator. 
 E. Parking Spaces occupied by the Generator shall be considered unreserved Parking Spaces (as defined on
Exhibit C) utilized by Tenant and shall be paid for by Tenant in accordance with the terms and provisions of Exhibit C. 

F. Tenant shall defend, indemnify and hold the Landlord Parties harmless from and against all Claims and liabilities of every kind or nature
related to the existence and operation of the Generator, except to the extent that such claims and liabilities are the result of the gross negligence or willful misconduct of any of the Landlord Parties. 

G. Throughout the Term, Landlord shall maintain a separate back-up power generator serving the Common Areas and emergency lighting in the
Complex. 

  
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 SEC. 55 FINANCIAL STATEMENTS: Tenant shall from time to time during the Term, but not more than twice in
any 12 month period, provide to Landlord an up to date true and accurate unaudited financial statement, balance sheet, and income and expense statement covering Tenant and any guarantor of Tenant’s obligations under this Lease Agreement, within
twenty (20) days after written request therefor is made by Landlord to Tenant. Except as may be required by law, Landlord agrees to keep any financial information provided pursuant to this Section 55 (the “Confidential
Information”) confidential; provided, however that (a) Landlord may make any disclosure of the Confidential Information to which Tenant has consented in writing in advance, and (b) any of the Confidential Information may be
disclosed to employees, partners, agents, successors, affiliates, assigns and representatives of Landlord, including, but not limited to, its auditors, attorneys, and lenders and potential purchasers and lenders of the Building in connection with
any financing or sale of the Building who (i) need to know the Confidential Information in connection therewith, (ii) shall have been informed by Landlord of the confidential nature of the Confidential Information, and (iii) shall
have agreed to treat the Confidential Information confidentially and to use it only for the purpose described above. 
 SEC. 56 LANDLORD DEFAULT: The
failure of Landlord to promptly and faithfully keep and perform each and every covenant, agreement, and stipulation herein on the part of Landlord to be kept and performed and the continuance of such failure for a period of thirty (30) days
after written notice to Landlord; or, if such failure cannot reasonably be cured within said thirty (30) day period despite Landlord’s diligent good faith efforts, the failure of Landlord to promptly commence its diligent good faith
efforts to cure such failure within said thirty (30) day period shall, at the option of Tenant, constitute a default by Landlord under this Lease Agreement. In the case of any breach or default of this Lease Agreement by Landlord, Tenant shall
have all of the remedies, rights, and authority against and with respect to Landlord provided by law, or in equity specifically including the right to injunctive relief. In the event of such failure by Landlord which continues for a period of ninety
(90) days notwithstanding Landlord’s efforts to cure, Tenant shall have the right at the end of such ninety (90) day period to deliver to Landlord written notice to terminate this Lease Agreement, which shall take effect thirty
(30) days after the date of such notice, except that Tenant’s right to terminate shall be null and void if the failure is cured during such thirty (30) day period. 

SEC. 57 EXHIBITS: Exhibits A through M are attached hereto and made a part of this Lease Agreement for all purposes. 

[END OF TEXT] 

  
 35 

 IN WITNESS WHEREOF, Landlord and Tenant, acting herein by duly authorized individuals, have
caused these presents to be executed in multiple counterparts (by facsimile, pdf or otherwise), each of which shall have the force and effect of an original on this 1st day of June, 2012 (the
“Effective Date”). 
  

					
	LANDLORD:
	
	 Sheridan Hills Developments L.P.,
 a
Texas limited partnership

		
	By:	 	Pouncet Sheridan Inc., an Ontario,
		 	Canada corporation, its general partner
			
		 	By:	 	 /s/ L. Lubin

		 	Name:	 	 L. Lubin

		 	Title:	 	 V.P.

  

			
	TENANT:
	
	Bellicum Pharmaceuticals, Inc., a Delaware corporation
		
	By:	 	 /s/ Thomas J. Farrell

	Name:	 	 Thomas J. Farrell

	Title:	 	 President & CEO

	
	ADDRESS:
	
	Prior to Commencement Date:
	410 Pierce Street
	Houston, Texas 77002
	
	Following the Commencement Date:
	At the Leased Premises

  
 36 

 EXHIBIT A 

FLOOR PLAN OF THE LEASED PREMISES 

See Attached 

  
 A-1 

  
 

 

 EXHIBIT A-1 

FLOOR PLAN OF THE HOLD SPACE 

See Attached 

  
 A-1-1 

  
 

 

 EXHIBIT B 

LEGAL DESCRIPTION OF THE LAND 
 All that
certain 2.3391 acres being all of Restricted Reserve “A”, Block 1, Twenty-One Thirty West Holcombe Boulevard Replat No. 1 according to the plat thereof as filed in Film Code Number 595196, Harris County Map Records, in the P. W. Rose
Survey, Abstract - 645, Houston, Harris County, Texas, and being more particularly described by metes and bounds as follows (bearings based on Texas Coordinate System of 1983, South Central Zone); 

Commencing at Harris County Floodplain Reference Mark Number 040110 being a brass disc stamped “040110” having published coordinates of (X:
3,110,377.78) and (Y: 13,820,307.50) from which Harris County Floodplain Reference Mark Number 040115 being a brass disc stamped “D100 BM16” bears S 70° 42’ 24” W - 1,730.12’ for reference; Thence N 36° 12’
56” W - 1,995.95’ to a found 3/4” iron pipe with cap (stamped C.L. DAVIS RPLS 4464) marking the southeast corner of said Restricted Reserve “A” from which a found 3/4” iron pipe bears N 79°
32’ 53” E - 0.69’ for reference and marking the POINT OF BEGINNING of herein described tract; 
 1. Thence S 87° 49’ 11” W
- 932.20’ with the north right-of-way line of West Holcombe Boulevard (120’ wide) to a found 1” iron pipe marking the southwest corner of said Restricted Reserve “A”; 

2. Thence N 02° 10’ 49” W - 104.62’ with the east right-of-way line of Mont Clair Drive (60’ wide) to a 1” pinch top pipe marking
the southwest corner of Lot 22, Block 7, Replat of Southgate Addition Section No. 3 according to the plat thereof as filed in Volume 26, Page 16, Harris County Map Records; 

3. Thence N 87° 52’ 11” E - 798.90’ north line of said Reserve “A” to a found 5/8” iron rod for corner; 

4. Thence N 59° 45’ 09” E - 151.07’ with the south line of Lots 9 - 11, Block 7 of said Replat of Southgate Addition, Section No. 3 to
a found 5/8’ iron rod for corner; 
 5. Thence S 02° 10’ 49” E - 175.00’ with the west line of that certain tract described in a
deed dated 06-30-1986 from Miller Hotel Development, Incorporated to Burger King Corporation as filed in Official Records of Real Property of Harris County at Clerk’s File Number K-700805, Film Code 056-71-1646 to the POINT OF BEGINNING and
containing 2.3391 (101,892 square feet) of land more or less. 

  
 B-1 

 EXHIBIT C 

PARKING AGREEMENT 

Landlord hereby agrees to make available to Tenant during the Term, as Tenant elects, up to four (4) unreserved parking passes for each
1,000 square feet of Net Rentable Area of the Leased Premises from time to time. Tenant shall be entitled from time to time to take and pay for all or any of such unreserved parking passes (and the parking spaces it is thereby entitled to use shall
be hereinafter collectively referred to as the “Parking Spaces”) for use in the Building parking garage (hereinafter referred to as the “Garage”), upon the following terms and conditions: 

 

	1.	Tenant shall pay as rental for the Parking Spaces the rates charged from time to time by the operator of the Garage, plus all taxes applicable thereto. The initial monthly rate for each of the Parking Spaces for
reserved parking shall be $240.00 plus taxes and for unreserved parking shall be $165.00 plus taxes. The charges for up to thirty-nine (39) unreserved Parking Spaces shall be abated for the first six (6) months following the Commencement
Date. Said rentals shall be due and payable to Landlord or its parking manager, as designated in writing by Landlord at the address of the Landlord’s property manager specified in Section 31 of this Lease Agreement (or such other address
as may be designated by Landlord in writing from time to time), as additional rent on the first day of each calendar month during the Term. 

  

	2.	In the event Tenant so desires, and upon ten (10) days’ prior written notice to Landlord, Tenant may convert up to ten percent (10%) of its Parking Spaces for unreserved parking to Parking Spaces for
reserved parking. In the event Tenant elects to convert such unreserved Parking Spaces to reserved Parking Spaces in accordance with this Paragraph 2, Landlord shall provide said Parking Spaces for reserved parking to Tenant during the balance of
the Term at the rates charged from time to time for reserved Parking Spaces in the Garage plus all taxes applicable thereto. From and after the date Tenant commences leasing such parking spaces for reserved parking, the term “Parking
Spaces” shall be deemed to include such reserved Parking Spaces. 

  

	3.	Notwithstanding anything contained in this Exhibit C to the contrary, Landlord shall have the right to recapture any Parking Space not utilized by Tenant for six (6) consecutive months beginning after
the first twelve (12) calendar months of the Term, and in the event Landlord exercises such right, Landlord shall have no further obligations to Tenant with respect to such Parking Spaces and the number of reserved or unreserved Parking Spaces,
as the case may be, referred to above in this Exhibit C shall be correspondingly reduced. 

  

	4.	Landlord will issue to Tenant parking tags, stickers or access cards for the Parking Spaces, or will provide a reasonable alternative means of identifying and controlling vehicles authorized to park in the contract
Garage. Tenant shall surrender each such tag, sticker or other identifying device to Landlord upon termination of the Parking Space related thereto. 

  

	5.	Landlord, at its discretion, shall have the right from time to time, upon written notice to Tenant, to designate the area(s) within which vehicles may be parked. Tenant agrees that although Landlord shall mark with
signage Tenant’s reserved Parking Spaces, Landlord shall have no obligation to enforce such reservation by ticketing, towing or affixing a notice to cars parked in Tenant’s reserved Parking Spaces by those who are not Tenant’s
customers, guests, invitees and employees; provided, however, Landlord will use commercially reasonable efforts to direct tenants at the Complex to abide by the parking rules. 

 

	6.	If for any reason beyond Landlord’s reasonable control Landlord fails or is unable to provide any of the Parking Spaces to Tenant at any time during the Term or any renewals or extensions hereof, and such
failure continues for two (2) business days after Tenant gives Landlord written notice thereof, Tenant’s obligation to pay rental for any Parking Space which is not provided by Landlord shall be abated for so long as Tenant
does not have the use thereof and Landlord shall use its diligent good faith efforts to provide alternative parking arrangements in the Garage or within a one-half (1/2) mile radius of the Building for the number of vehicles equal to the
number of Parking Spaces not provided by Landlord. Tenant shall pay for any alternative parking provided by Landlord so long as Tenant is not paying rent for the Parking 

  
 C-1 

	 	
Spaces. This abatement and good faith effort to provide alternative parking arrangements shall be in full settlement of all claims that Tenant might otherwise have against Landlord by reason of
Landlord’s failure or inability to provide Tenant with the Parking Spaces. 

  

	7.	If the Term commences on other than the first day of a calendar month or terminates on other than the last day of a calendar month, then rentals for the Parking Spaces shall be prorated on a daily basis.

  

	8.	Tenant shall indemnify, defend (with counsel reasonably acceptable to Landlord) and hold harmless the Landlord Parties from and against all liabilities, obligations, losses, damages, penalties, claims, actions, suits,
costs, expenses and disbursements (including court costs and reasonable attorneys’ fees) resulting directly or indirectly from the use of the Parking Spaces, unless caused by the gross negligence or willful misconduct of Landlord or the
Landlord Parties. 

  

	9.	Landlord may provide parking in the Garage or in surface lots for visitors to the Building in an area designated by Landlord and in a capacity determined by Landlord to be appropriate for the Building. Landlord reserves
the right to charge and collect a fee for parking in the visitor Garage or in the surface lots in an amount determined by Landlord or the operator of the Garage to be appropriate. Provided that no Event of Default has occurred, Landlord agrees to
allow Tenant to validate the parking ticket of Tenant’s visitors with a stamp or other means approved in advance by Landlord, and to bill Tenant for the parking charges so validated by Tenant on a monthly basis. Said visitor parking charges
shall be due and payable to Landlord as additional rent within ten (10) days after Tenant’s receipt of such statement. Alternatively, Landlord may establish a parking validation program whereby tenants may, at their option, purchase
prepaid parking validation stickers or other means of identification for specific increments of visitor parking charges, which the tenants may then distribute to their visitors and invitees to be submitted to the Garage attendant as payment for the
applicable increment of visitor parking charge. 

  

	10.	Upon the occurrence of an Event of Default, Landlord shall have the right (in addition to all other rights, remedies and recourse hereunder and at law) to terminate Tenant’s use of the Parking Spaces without prior
notice or warning to Tenant. 

  

	11.	Landlord shall have the right to relocate the Garage to any future parking facilities Landlord may construct on the Land, provided Tenant has use of at least 4 parking spaces for each 1,000 square feet of Net Rentable
Area of the lased Premises. 

 A condition of any parking shall be compliance by the parker with Garage rules and regulations, including any
sticker or other identification system established by Landlord. The following rules and regulations are in effect until notice is given to Tenant of any change. Landlord reserves the right to modify and/or adopt such other reasonable rules and
regulations for the Garage as it deems necessary for the operation of the Garage. Landlord may refuse to permit any person who violates the rules to park in the Garage, and any violation of the rules shall subject the car to removal. 

  
 C-2 

 PARKING RULES AND REGULATIONS 

 

	1.	Cars must be parked entirely within the stall lines painted on the floor. 

  

	2.	All directional signs and arrows and signs designating wheelchair accessible parking spaces must be observed. 

  

	3.	The speed limit shall be five (5) miles per hour. 

  

	4.	Parking prohibited: 

  

	 	(a)	in areas not striped for parking 

  

	 	(b)	in aisles 

  

	 	(c)	where “no parking” signs are posted 

  

	 	(d)	on ramps where indicated 

  

	 	(e)	in cross-hatched areas in spaces reserved for exclusive use by designated lessees 

  

	 	(g)	in such other areas as may be designated by Landlord or Landlord’s agent(s). 

  

	5.	Parking stickers or any other device or form of identification supplied by Landlord shall remain the property of Landlord and shall not be transferable. There will be a replacement charge payable by Tenant equal to the
amount posted from time to time by Landlord for loss of any parking card or parking sticker. 

  

	6.	Garage managers and attendants are not authorized to make or allow any exceptions to these Rules and Regulations. 

  

	7.	Every parker is required to park and lock his own car. All responsibility for loss or damage to cars and contents, property or persons is assumed by the parker. 

 

	8.	Tenant is required to give Landlord, on a quarterly basis, a list of employees parking in the Garage which shall include year, make and model of car and license number. 

 

	9.	In order to protect Landlord’s property, Landlord shall have the right, but not the obligation, to install cameras in the Garage. 

 

	10.	Landlord is entitled to limit the size of the parked vehicles by weight, height or width without constituting a breach of its obligation to provide parking hereunder. 

Failure to promptly pay the rent required hereunder or persistent failure on the part of Tenant or Tenant’s designated parkers to observe the Rules and
Regulations above shall give Landlord the right to terminate Tenant’s right to use the parking structure. No such termination shall create any liability on Landlord or be deemed to interfere with Tenant’s right to quiet possession of its
Leased Premises. 

  
 C-3 

 EXHIBIT D 

RULES AND REGULATIONS 
 The following
standards shall be observed by Tenant for the common safety, cleanliness and convenience of all occupants of the Building. These rules are subject to change from time to time, as specified in the Lease Agreement. 

 

	1.	All tenants will refer all contractors’ representatives and installation technicians who are to perform any work within the Building to Landlord for Landlord’s supervision, approval (which approval shall
not be unreasonably withheld, conditioned or delayed) and control before the performance of any such work. This provision shall apply to all work performed in the Building including, but not limited to, installations of telephones, computer
equipment, electrical devices and attachments, and any and all installations of every nature affecting floors, walls, woodwork, trim, windows, ceilings, equipment and any other physical portion of the Building. Tenant shall not mark, paint,
drill into, or in any way deface any part of the Building or the Leased Premises, except with the prior written consent of the Landlord, and as the Landlord may direct; provided, however, Tenant may hang pictures, bulletin boards, white boards and
the like within the Leased Premises without prior consent of or notice to Landlord. 

  

	2.	The work of the janitorial or cleaning personnel shall not be hindered by Tenant after 5:30 p.m., and such work may be done at any time when the offices are vacant. The windows, doors and fixtures may be cleaned at any
time. Tenant shall provide adequate waste and rubbish receptacles, cabinets, book cases, map cases, etc., necessary to prevent unreasonable hardship to Landlord in discharging its obligations regarding cleaning service. 

 

	3.	Prior to the commencement of any construction in the Leased Premises, Tenant shall deliver evidence of its contractor’s and subcontractor’s insurance, such insurance being with such companies, for such periods
and in such amounts as Landlord may reasonably require, naming the Landlord Parties as additional insureds. 

  

	4.	No sign, advertisement or notice shall be displayed, painted or affixed by Tenant, its agents, servants or employees, in or on any part of the outside or inside of the Building or Leased Premises without prior written
consent of Landlord, and then only of such color, size, character, style and material and in such places as shall be approved and designated by Landlord. Signs on doors and entrances to the Leased Premises shall be placed thereon by Landlord.

  

	5.	Except as otherwise provided in this Lease Agreement and for such items as are installed as part of the Leasehold Improvements, Tenant shall not place, install or operate on the Leased Premises or in any part of the
Building any engine, refrigerating, heating or air conditioning apparatus, stove or machinery, or conduct mechanical operations, or place or use in or about the Leased Premises any inflammable, explosive, hazardous or odorous solvents or materials
without the prior written consent of Landlord. No portion of the Leased Premises shall at any time be used for cooking, sleeping or lodging quarters. Tenant may use coffee pots, refrigerators and microwaves in Leased Premises. 

 

	6.	Tenant shall not make or permit any loud or improper noises in the Building or otherwise interfere in any way with other tenants. 

  

	7.	Landlord will not be responsible for any lost or stolen personal property or equipment from the Leased Premises or public areas, regardless of whether such loss occurs when the area is locked against entry or not.

  

	8.	Tenant, or the employees, agents, servants, visitors or licensees of Tenant, shall not, at any time or place, leave or discard rubbish, paper, articles, plants or objects of any kind whatsoever outside the doors of the
Leased Premises or in the corridors or passageways of the Building or attached Parking Areas. No animals (other than mice in any vivarium), bicycles or vehicles of any description shall be brought into or kept in or about the Building, except for
Landlord designated bicycle parking areas. 

  
 D-4 

	9.	No additional lock or locks shall be placed by Tenant on any door in the Building unless written consent of Landlord shall have first been obtained. Two (2) keys will be furnished by Landlord for the Leased
Premises, and any additional key required must be obtained from Landlord. A charge will be made for each additional key furnished. All keys shall be surrendered to Landlord upon termination of tenancy. 

 

	10.	None of the entries, passages, doors, hallways or stairways in the Building shall be blocked or obstructed. 

  

	11.	Landlord shall have the right to determine and prescribe the weight and proper position of any unusually heavy equipment, including computers, safes, large files, etc., that are to be placed in the Building, and only
those which in the exclusive judgment of the Landlord will not do damage to the floors, structure and/or elevators may be moved into the Building. Any damage caused by installing, moving or removing such aforementioned articles in the Building shall
be paid for by Tenant. 

  

	12.	All holiday and other decorations must be constructed of flame retardant materials. Live Christmas trees are not permitted in the Leased Premises. 

 

	13.	Tenant shall provide Landlord with a list of all personnel authorized to enter the Building after hours (6:00 p.m. to 7:00 a.m. Monday through Friday, and 24 hours a day on Saturdays, Sundays and Holidays).

  

	14.	The following dates shall constitute “Holidays” as said term is used in this Lease Agreement: New Year’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving, the Friday following
Thanksgiving Day and Christmas and any other holiday recognized and taken by tenants cumulatively occupying at least one-half (1/2) of the Net Rentable Area of office space of the Building. The Holidays set forth herein may not be changed by
Landlord during the Term. 

  

	15.	The following hours shall constitute the normal business hours of the Building: between 7:00 a.m. and 6:00 p.m. from Monday through Friday and between 8:00 a.m. and 12:00 noon on Saturdays, all exclusive of Holidays.
The aforementioned hours of operation may not be changed by Landlord during the Term. 

  

	16.	Movement of furniture or office equipment in or out of the Building, or dispatch or receipt by Tenant of any heavy equipment, bulky material or merchandise which requires use of elevators or stairways, or movement
through the Building’s service dock or lobby entrance shall be restricted to such hours as Landlord shall designate. All such movement shall be in a manner to be agreed upon between Tenant and Landlord in advance. Such prior arrangements shall
be initiated by Tenant. The time, method and routing of movement and limitations for safety or other concern which may prohibit any article, equipment or other item from being brought into the Building shall be subject to Landlord’s reasonable
discretion and control. Any hand trucks, carryalls or similar appliances used for the delivery or receipt of merchandise or equipment shall be equipped with rubber tires, side guards and such other safeguards as the Building shall require. Although
Landlord or its personnel may participate in or assist in the supervision of such movement, Tenant assumes full responsibility for all risks as to damage to articles moved and injury to persons or property engaged in such movement, including
equipment, property and personnel of Landlord if damaged or injured as a result of acts in connection with carrying out this service for Tenant, from the time of entering the property to completion of work. Landlord shall not be liable for the acts
of any person engaged in, or any damage or loss to any of said property or persons resulting from any act in connection with such service performed for Tenant. 

  

	17.	Landlord shall designate one elevator to be the freight elevator to be used to handle packages and shipments of all kinds. The freight elevator shall be available to handle such deliveries from 9:00 a.m. to 11:00 a.m.
and 2:00 p.m. to 3:30 p.m. weekdays. Parcel Post, express, freight or merchants’ deliveries can be made anytime within these hours. No furniture or freight shall be handled outside the above hours, except by previous arrangement.

  

	18.	Any additional services as are routinely provided to tenants, not required by the Lease Agreement to be performed by Landlord, which Tenant requests Landlord to perform, and which are performed by Landlord, shall be
billed to Tenant at Landlord’s cost plus five percent (5%). 

  
 D-5 

	19.	All doors leading from public corridors to the Leased Premises are to be kept closed when not in use. 

  

	20.	Canvassing, soliciting or peddling in the Building is prohibited and Tenant shall cooperate to prevent same. 

  

	21.	Tenant shall give immediate notice to the Building Manager in case of accidents in the Leased Premises or in the Building or of defects therein or in any fixtures or equipment, or of any known emergency in the Building.

  

	22.	Tenant shall not use the Leased Premises or permit the Leased Premises to be used for photographic, multilith or multigraph reproductions, except in connection with its own business. 

 

	23.	The requirements of Tenant will be attended to only upon application to the Building Manager. Employees of Landlord shall not perform any work or do anything outside of their regular duties, unless under special
instructions from the Building Manager. 

  

	24.	Tenant shall place or have placed solid pads under all rolling chairs such as may be used at desks or tables. Any damages caused to carpet by not having same shall be repaired or replaced at the expense of Tenant.

  

	25.	Tenant, or the employees, agents, servants, visitors or licensees of Tenant shall abide by the rules and regulations for the Parking Areas included in the Parking Agreement attached hereto as Exhibit C.

  

	26.	Except as otherwise noted, Landlord reserves the right to rescind any of these Rules and Regulations of the Building, and to make such other and further rules and regulations as in its reasonable judgment shall from
time to time be needful for the safety, protection, care and cleanliness of the Building, the Leased Premises and the Parking Areas, the operation thereof, the preservation of good order therein and the protection and comfort of the other tenants in
the Building and their agents, employees and invitees, which rules and regulations, when made and written notice thereof is given to Tenant, shall be binding upon Tenant in like manner as if originally herein prescribed, provided such changes do not
unreasonably interfere with Tenant’s use or occupancy of or access to the Leased Premises. 

  

	27.	Landlord will provide 4.0 cardkeys or other access devices per 1,000 square feet of Net Rentable Area of the Leased Premises during the Term to Tenant and Tenant agrees to return all of these cardkeys and other access
devices to Landlord upon expiration or termination of this Lease Agreement. All others will be furnished to Tenant at a cost of Fifty and 00/100 Dollars ($50.00) per card or a mutually agreed upon price for each other access device. Any future
increase in the cost of cardkeys and other access devices will be passed on to Tenant for any additional cardkeys and other access devices required. 

  

	28.	Tenant, or its employees, agents, servants, visitors, invitees or licensees of Tenant, shall not smoke or permit to be smoked cigarettes, cigars or pipes within the Leased Premises or Building. Smoking shall be confined
to area(s) designated by Landlord but shall in no event be closer than twenty-five feet (25’) to any entrance to the Building. Landlord shall have no obligation to Tenant for failure of another tenant, its employees, agents, servants,
visitors, invitees or licensees to comply with this paragraph. 

  

	29.	Tenant shall not attempt to adjust wall-mounted thermostats in the Building. If there is any damage to wall-mounted thermostats due to attempts by Tenant to adjust thermostats, Landlord may repair such damage at the
sole cost and expense of the Tenant. 

  
 D-6 

 EXHIBIT E 

ACCEPTANCE OF PREMISES MEMORANDUM 
 This
Memorandum is an amendment to the Lease Agreement for space in 2130 West Holcombe Boulevard, Suite 850 Houston, Harris County, Texas 77030, executed on the      day of June, 2012 between Sheridan Hills Developments L.P., a Texas
limited partnership, as Landlord and Bellicum Pharmaceuticals, Inc., a Delaware corporation, as Tenant. 
 Landlord and Tenant hereby agree that: 

 

	1.	The Leased Premises consists of          square feet of Net Rentable Area. 

  

	2.	Except for those items shown on the attached “punch list”, if any, which Landlord will remedy within 30 days hereof, Landlord has fully completed the construction work required under the terms of the Lease
Agreement. 

  

	3.	The Leased Premises are tenantable, the Landlord has no further obligation for construction (except as specified above), and Tenant acknowledges that both the Building and the Leased Premises are satisfactory in all
respects. 

  

	4.	The Commencement Date of the Lease Agreement is hereby agreed to be the      day of             , 201    .

  

	5.	The Expiration Date of the Lease Agreement is hereby agreed to be the      day of              201    ,

 All other terms and conditions of the Lease Agreement are hereby ratified and acknowledged to be unchanged. 

Agreed and Executed this      day of             ,
201    . 
  

					
	Landlord:
	
	 Sheridan Hills Developments L.P.,
 a
Texas limited partnership

		
	By:	 	Pouncet Sheridan Inc., an Ontario,
		 	Canada corporation, its general partner
			
		 	By:	 	  

		 	Name:	 	  

		 	Title:	 	  

	
	Tenant:
	
	Bellicum Pharmaceuticals, Inc.
		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 E-1 

 EXHIBIT F 

TENANT’S ESTOPPEL CERTIFICATE 

(Addressee) 
  

	RE:	                    Houston, Texas 

Gentlemen: 
 The undersigned (“Tenant”)
has executed and entered into that certain lease agreement (“Lease Agreement”) attached hereto as Exhibit A and made a part hereof for all purposes with respect to those certain premises (“Leased
Premises”) which are located in the above-referenced project (“Project”) and are more fully described in the Lease Agreement. Tenant understands that the entity to whom this letter is addressed
(“Addressee”) has committed to loan or invest a substantial sum of money in reliance upon this certification by the undersigned, which certification is a condition precedent to making such loan or investment, or that Addressee
intends to take some other action in reliance upon this certification. 
 With respect to the Lease Agreement, Tenant certifies to you the following,
with the intention that you may rely fully thereon: 
  

	1.	A true and correct copy of the Lease Agreement, including any and all amendments and modifications thereto, is attached hereto as Exhibit A; 

 

	2.	The original Lease Agreement is dated             , 201    , and has been assigned, modified, supplemented or amended only in the following
respects: 

 (Please write “None” above or, on a separate sheet of paper, state the effective date of and describe
any oral or written modifications, supplements or amendments to the Lease Agreement and attach a copy of such modifications, supplements or amendments, with the Lease Agreement as Exhibit A); 

 

	3.	Tenant is in actual occupancy of the Leased Premises under the Lease Agreement; the Leased Premises are known as Suite         , of the Project; and the Leased Premises contain
approximately                       square feet; 

  

	4.	The initial term of the Lease Agreement commenced on             , 201    , and ends at 11:59 p.m. on
            , 201    , at a monthly base rent of $        ,and no rentals or other payments in advance of the current calendar
month have been paid by Tenant, except as follows: 

 (Please write “None” above or describe such payments on a
separate sheet of paper); 
  

	5.	Base Rent with respect to the Lease Agreement has been paid by Tenant through             , 201    ; all additional rents and other charges
have been paid for the current periods; 

  

	6.	There are no unpaid concessions, bonuses, free months’ rent, rebates or other matters affecting the rent for Tenant, except as follows: 

(Please write “None” above or describe such matters on a separate sheet of paper); 

  
 F-1 

	7.	No security or other deposit has been paid by Tenant with respect to the Lease Agreement, except as follows: 

(Please write “None” above or describe such deposits on a separate sheet of paper); 

 

	8.	The Lease Agreement is in full force and effect and, to Tenant’s current actual knowledge, there are no events or conditions existing which, with notice or the lapse of time or both, could constitute a monetary or
other default of the Landlord under the Lease Agreement, or entitle Tenant to any offset or defense against the prompt current payment of rent or constitute a default by Tenant under the Lease Agreement, except as follows: 

(Please write “None” above or describe such default on a separate sheet of paper); 

 

	9.	All improvements required to be made by Landlord under the terms of the Lease Agreement have been satisfactorily completed and accepted by Tenant as being in conformity with the Lease Agreement, except as follows:

 (Please write “None” above or describe such improvements on a separate sheet of paper); 

 

	10.	Tenant has no option to expand or rent additional space within the Project or any right of first refusal with regard to any additional space within the Project, other than the Leased Premises, except as follows:

 (Please write “None” above or describe such right or option on a separate sheet of paper); 

 

	11.	Tenant has no right or option to renew the Lease Agreement for any period of time after the expiration of the initial term of the Lease Agreement, except as follows: 

(Please write “None” above or describe such right on a separate sheet of paper); 

 

	12.	To Tenant’s current actual knowledge, any and all broker’s leasing and other commissions relating to and/or resulting from Tenant’s execution of the Lease Agreement and occupancy of the Leased Premises
have been paid in full and no broker’s leasing or other commissions will be or become due or payable in connection with or as a result of either Tenant’s execution of a new Lease Agreement covering all or any portion of the Leased Premises
or any other space within the Project or Tenant’s renewal of the Lease Agreement, except as follows: 

 (Please write
“None” above or describe such right on a separate sheet of paper); 
  

	13.	To Tenant’s current actual knowledge, the use, maintenance or operation of the Leased Premises complies with, and will at all times comply with, all applicable federal, state, county or local statutes, laws, rules
and regulations of any governmental authorities relating to environmental, health or safety matters (being hereinafter collectively referred to as the “Environmental Laws”); 

 

	14.	[intentionally deleted]; 

  

	15.	Tenant has not received any notices, written or oral, of violation of any Environmental Law or of any allegation which, if true, would contradict anything contained herein and there are not writs, injunctions, decrees,
orders or judgments outstanding, no lawsuits, claims, proceedings or investigations pending or threatened, relating to the use, maintenance or operation of the Leased Premises, nor is Tenant aware of a basis for any such proceeding;

  

	16.	There are no actions, whether voluntary or otherwise, pending against Tenant under the bankruptcy or insolvency laws of the United States or of any state. 

 

	17.	Tenant has no right of refusal or option to purchase the Leased Premises or the Project. 

  

	18.	Tenant understands that the Lease Agreement may be assigned to Addressee and Tenant agrees to attorn to Addressee in all respects in accordance with the Lease Agreement. 

  
 F-2 

 Dated:             , 201    .

  

			
	Very truly yours,
	
	Bellicum Pharmaceuticals, Inc.
		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 F-3 

 EXHIBIT G 

LEASEHOLD IMPROVEMENTS 

1. Work by Landlord. Landlord shall cause to be constructed and/or installed in the Leased Premises the permanent leasehold
improvements and tenant finish desired by Tenant and approved by Landlord, which approval shall not be unreasonably withheld, conditioned or delayed (the “Leasehold Improvements”). The leasehold construction will be performed
pursuant to a cost plus contract entered into by Landlord with a general contractor agreed on by Landlord and Tenant. 
 2. Planning and
Construction. 
 (a) Landlord and Tenant shall cooperate in good faith in the planning and construction of the Leasehold Improvements,
it being agreed and understood that it is the intent and desire of the parties that the Leased Premises be ready for Tenant’s occupancy on or before the Estimated Leased Premises Delivery Date. Tenant shall respond within five (5) business
days to any request from Landlord or Landlord’s architect or contractor for Tenant’s approval of any particular aspect thereof. To the extent Tenant engages Landlord’s consultants as Tenant’s mechanical/electrical/plumbing and/or
structural engineering consultants, Landlord shall not require reimbursement of third-party fee charges to Landlord for review of Tenant’s plans and documents by the consultants so engaged. 

(b) Tenant will cause its architect and engineers (the “Design Professionals”) to prepare a set of space plans
(the “Proposed Space Plans”) for the Leasehold Improvements and submit same to Landlord for its review and approval within fourteen (14) days following the Effective Date. Within ten (10) business days after delivery of
the Proposed Space Plans to Landlord, Landlord shall either approve (which approval shall not be unreasonably withheld, conditioned or delayed) the Proposed Space Plans or notify Tenant of the item(s) of the Proposed Space Plans that Landlord
disapproves and the reason(s) therefor. If Landlord disapproves the Proposed Space Plans, Tenant shall cause the Design Professionals to revise and resubmit same to Landlord for approval within five (5) business days (the “Revised
Space Plans”). Within five (5) business days after delivery of the Revised Space Plans to Landlord, Landlord shall either approve the Revised Space Plans or notify Tenant of the item(s) of the Revised Space Plans which Landlord
disapproves and the reason(s) therefor. If Landlord disapproves the Revised Space Plans, Tenant shall cause the Design Professionals to further revise and resubmit same to Landlord for approval within five (5) business days, which process
shall continue until the plans are approved. Landlord shall have five (5) business days after delivery of each set of Revised Space Plans to either approve the Revised Space Plans or notify Tenant of the item(s) of the Revised Space Plans which
Landlord disapproves and the reason(s) therefor. The Proposed Space Plans or Revised Space Plans, as approved by Landlord, are hereinafter referred to as the “Space Plans”. 

(c) Upon Landlord’s approval of the Space Plans, Tenant shall cause the Design Professionals to prepare construction drawings
(in accordance with the Space Plans) and specifications including complete sets of detailed architectural, structural, mechanical, electrical and plumbing working drawings (the “Proposed Construction Drawings”) for the Leasehold
Improvements and shall deliver the Proposed Construction Drawings to Landlord for approval (which approval shall not be unreasonably withheld, conditioned or delayed). Within ten (10) business days after delivery of the Proposed Construction
Drawings to Landlord, Landlord shall either approve the Proposed Construction Drawings or notify Tenant of the item(s) of the Proposed Construction Drawings that Landlord disapproves and the reason(s) therefor. If Landlord disapproves the Proposed
Construction Drawings, Tenant shall cause the Design Professionals to revise and resubmit same to Landlord for approval within five (5) business days (the “Revised Construction Drawings”). Within five (5) business days
after delivery of the Revised Construction Drawings to Landlord, Landlord shall either approve the Revised Construction Drawings or notify Tenant of the item(s) of the Revised Construction Drawings which Landlord disapproves and the reason(s)
therefor. If Landlord disapproves the Revised Construction Drawings, Tenant shall cause the Design Professionals to further revise and resubmit same to Landlord for approval within five (5) business days, which process shall continue until the
plans are approved. Landlord shall have five (5) business days after delivery of each set of Revised Construction Drawings to either approve the Revised Construction Drawings or notify Tenant of the item(s) of the Revised Construction Drawings
which Landlord disapproves and the reason(s) therefor. The Proposed Construction Drawings or Revised Construction Drawings, as approved by Landlord, are hereinafter referred to as the “Construction Drawings”. 

  
 G-1 

 3. Quality of Work. Landlord shall supervise the construction of the Leasehold
Improvements in conformance with the Construction Drawings and shall use its diligent good faith efforts to cause same to be constructed and installed in a good and workmanlike manner in accordance with good industry practice. 

4. Completion of Construction. The “Leasehold Improvements Completion Date” shall mean the date upon which the Leasehold
Improvements are substantially complete in accordance with the Construction Drawings. The phrase “substantially complete” shall mean that all construction debris has been removed from the Leased Premises and the Leased Premises are
reasonably clean, the Leasehold Improvements have been completed in substantial accordance with the Construction Drawings therefor, except for the completion of Punch List Items (hereinafter defined), and Landlord shall have obtained and delivered
to Tenant a temporary certificate of occupancy for the Leased Premises. Landlord will give Tenant ten (10) days’ advance written notice of the date on which Landlord expects the Leased Premises to be substantially complete and ready for
occupancy. If the Leased Premises are not ready for occupancy by the Estimated Leased Premises Delivery Date for any reason, Landlord shall not be liable or responsible for any claims, damages or liabilities in connection therewith or by reason
thereof. The term “Punch List Items” shall mean details of construction, decoration and mechanical adjustment which, in the aggregate, are relatively minor in character and do not materially interfere with the use or enjoyment of the
Leased Premises for the uses permitted in Section 3 of this Lease Agreement. The Punch List Items shall be set forth in a list prepared during a walkthrough inspection of the Leased Premises, such inspection to be performed by Tenant’s and
Landlord’s representatives within ten (10) days after Landlord shall advise Tenant that substantial completion of the Leasehold Improvements in the Leased Premises has occurred or is imminent. Landlord shall use its commercially reasonable
efforts to cause the Punch List Items to be substantially completed within thirty (30) days after said walkthrough inspection and Landlord and Tenant’s agreement on the Punch List Items. Additionally, Landlord shall use its commercially
reasonable efforts to obtain and deliver to Tenant a final (permanent) certificate of occupancy for the Leased Premises within ninety (90) after substantial completion. 

5. Tenant Delay. As used herein, “Tenant Delay” shall mean the sum of (i) the number of days of delay beyond the
5-business day response period in responding to Landlord’s request for approval of any documentation in connection with the Leasehold Improvements, (ii) the number of days of delay in preparing any of such documentation caused by changes
requested by Tenant to any aspect of the Leasehold Improvements which were reflected in the documentation theretofore approved by Tenant, (iii) the number of days of delay in completing the Leasehold Improvements caused by the Tenant’s
early entry into the Leased Premises pursuant to Section 2.B of the Lease Agreement and (iv) the positive difference, if any, between the increase and decrease in the number of days required to complete the Leasehold Improvements caused by
changes requested by Tenant to the working drawings after Tenant’s approval thereof, in all instances net of any delay on the part of Landlord, its employees, agents or contractors. 

6. Disclaimer of Warranty. TENANT ACKNOWLEDGES THAT THE CONSTRUCTION AND INSTALLATION OF THE LEASEHOLD IMPROVEMENTS WILL BE
PERFORMED BY AN UNAFFILIATED CONTRACTOR OR CONTRACTORS AND THAT ACCORDINGLY LANDLORD HAS MADE AND WILL MAKE NO WARRANTIES TO TENANT WITH RESPECT TO THE QUALITY OF CONSTRUCTION THEREOF OR AS TO THE CONDITION OF THE LEASED PREMISES, EITHER EXPRESS OR
IMPLIED, AND THAT LANDLORD EXPRESSLY DISCLAIMS ANY IMPLIED WARRANTY THAT THE LEASED PREMISES ARE OR WILL BE SUITABLE FOR TENANT’S INTENDED COMMERCIAL PURPOSE. AS SET FORTH IN SECTION 27 OF THE LEASE, TENANT’S OBLIGATION TO PAY BASE AND
ADDITIONAL RENTAL HEREUNDER IS NOT DEPENDENT UPON THE CONDITION OF THE LEASED PREMISES OR THE BUILDING OR THE PERFORMANCE BY LANDLORD OF ITS OBLIGATIONS HEREUNDER, AND TENANT SHALL CONTINUE TO PAY THE BASE AND ADDITIONAL RENT WITHOUT ABATEMENT,
SETOFF OR DEDUCTION, NOTWITHSTANDING ANY BREACH BY LANDLORD OF ITS DUTIES OR OBLIGATIONS HEREUNDER, WHETHER EXPRESS OR IMPLIED, EXCEPT AS OTHERWISE PROVIDED IN THIS LEASE AGREEMENT. However, Landlord agrees that in the event that any defect in
the construction of the Leasehold Improvements are discovered, Landlord will diligently pursue and seek to enforce any warranties of the contractor(s) and/or the manufacturer of any defective materials incorporated therein. 

  
 G-2 

 7. Cost of Leasehold Improvements. Landlord shall pay all costs and expenses of the
Leasehold Improvements (including labor, materials, construction management, architectural and engineering costs) up to the aggregate amount of $45.00 per square foot of Net Rentable Area of the Leased Premises (the “Improvement
Allowance”). Landlord shall pay any invoices for consultants engaged directly by Tenant out of the Improvement Allowance within thirty (30) days after delivery. In the event that the cost and expense of constructing and installing any
portion of the Leasehold Improvements exceeds the Improvement Allowance (the “Excess Cost”), then prior to Landlord’s awarding of the construction contract with respect to the Leasehold Improvements or, as applicable, Landlord
performing any change order work, Tenant shall deposit with Landlord, one hundred ten percent (110%) of the amount of Landlord’s good faith, reasonable estimate of any Excess Cost, or security therefor in a form reasonably acceptable to
Landlord. No more frequently than monthly, Landlord shall invoice Tenant for the portion of the Excess Cost expended by Landlord and unpaid by Tenant. Tenant shall pay the invoiced amount within ten (10) business days thereafter. Tenant shall
be entitled to authorize Landlord to draw on its security for the invoice amount (plus any costs incurred by Landlord as a result of the draw), provided that the remaining security shall at all times be at least one hundred ten percent
(110%) of the then-projected Excess Cost not yet expended. If Tenant pays the invoice amount, Landlord shall approve a reduction in the amount of the security, to an amount equal to one hundred ten percent (110%) of the then-projected
Excess Cost not yet expended. In the event that any portion of the Improvement Allowance remains unused on the Leasehold Improvements Completion Date, Tenant shall have the option to have such unused amounts applied to Base Rent first due under this
Lease Agreement. Notwithstanding anything in this Paragraph 7 to the contrary, the Improvement Allowance shall be reduced by an amount equal to the actual, reasonable cost (including labor, materials, construction management, architectural and
engineering costs) of two (2) replacement restrooms to be constructed by Landlord on the eighth (8th) floor outside the Leased Premises, which replacement restrooms will be substantially similar in finish-out to the existing restrooms on
the eighth (8th) floor and meet all applicable governmental codes, laws and regulations. 
 8. Construction Management Fee.
Tenant acknowledges and agrees to pay Landlord a construction management fee equal to five percent (5%) of the total costs and expenses of the Leasehold Improvements, excluding “soft” costs incurred by Tenant, such as Tenant’s
interior architect and third-party consultants retained directly by Tenant. Such construction management fee may be paid for by Tenant out of the Improvement Allowance. 

9. Builder’s Risk Insurance. Landlord shall cause the general contractor to obtain and maintain Builder’s Risk insurance on
an “all risk” basis and on a completed value form including a Permission to Complete and Occupy endorsement, for full replacement value of the Leasehold Improvements, such policy naming Landlord and Tenant as additional insureds. The cost
of such insurance shall be paid for out of the Improvement Allowance. 

  
 G-3 

 EXHIBIT H 

AIR CONDITIONING AND HEATING SERVICES 

Landlord will furnish Building standard chilled water for air conditioning and heating at such temperatures and in such amounts as are
considered to be standard for other comparable medical office buildings in and in the vicinity of the Texas Medical Center area of Houston, Texas, twenty-four (24) hours per day, seven (7) days per week, to be paid for by Tenant as
described below. Landlord shall install, as part of the Leasehold Improvements, to be paid for out of the Improvement Allowance, separate metering for all of Tenant’s HVAC air handling units, heat exchangers and fan coil units (such HVAC air
handling units, heat exchangers and fan coil units are hereinafter collectively referred to as the “HVAC Equipment” and such meters are hereinafter referred to as the “BTU Meters”). Tenant shall maintain and repair
the HVAC Equipment and BTU Meters at Tenant’s expense. The BTU Meters measure the energy consumed by the HVAC Equipment in British Thermal Units (“BTUs”). Tenant will pay Landlord the cost of the energy consumed by the
HVAC Equipment (the “Submetered BTU Charges”), which cost shall be the product of (x) the BTUs (in millions) consumed during such month by the HVAC Equipment (as evidenced by the BTU Meters), multiplied by (y) the
then-current per million BTU amount charged by Landlord in the Building generally to tenants leasing space in the tower portion of the Building, which amount shall be determined using the formula shown on Exhibit H-1 attached hereto
and made a part hereof for all purposes. Tenant acknowledges that Exhibit II-I applies the formula to the information available to Landlord as of the Effective Date, and that the amounts will be adjusted as of the Commencement Date
based on updated information and thereafter from time to time based on the Kilowatt Hour Rate (as defined below). The “Kilowatt Hour Rate” shall mean the actual average cost per kilowatt hour charged by the utility company providing
electricity to Landlord in the Building or, if said utility company shall cease charging for electricity on the basis of a kilowatt hour, then the Kilowatt Hour Rate shall mean the actual average cost per unit of measurement substituted therefor by
said utility company. Tenant acknowledges that, during the Term, the Kilowatt Hour Rate is subject to fluctuation as prescribed by the applicable utility company. Landlord shall provide an invoice to Tenant for the Submetered BTU Charges on a
monthly basis in arrears, which shall be paid by Tenant as Additional Rent on or before the first day of the calendar month following the month the invoice is provided, along with the remainder of the Additional Rent then due and owing by Tenant.

  
 H-1 

 EXHIBIT H – I 

HVAC CALCULATIONS 
  

					
	Summary Calculations	  		 	Last updated: 4/16/2012
	Assumed Electrical Rate, $/KWHr	  	$0.07919	 	Last printed: 4/16/2012

  

																									
	 Power consumption at Full load
	  	kw/ton	 	  	horsepower/
ton	 	  	watts/ton	 	  	kw/ton	 	  	kwh cost	 	  	Cost/ton
per hour	 
	 Chillers
	  	 	0.6505	  	  				  				  	 	0.6505	  	  	$	0.792	  	  	$	0.0515	  
	 Condenser water pumps
	  				  	 	0.0833	  	  	 	62.25	  	  	 	0.0623	  	  	$	0.792	  	  	$	0.0049	  
	 Cooling towers
	  				  	 	0.0694	  	  	 	51.875	  	  	 	0.0519	  	  	$	0.792	  	  	$	0.0041	  
	 Chilled water pumps
	  				  	 	0.1111	  	  	 	83	  	  	 	0.0830	  	  	$	0.792	  	  	$	0.0066	  
	 Accessories and misc, items
	  				  				  	 	4	  	  	 	0.0040	  	  	$	0.792	  	  	$	0.0003	  
		  				  				  				  	  
	  
	 	  				  	  
	  
	 
		  				  				  				  	 	0.8516	  	  				  	$	0.0674	  

  

																					
	 Depreciation of Equipment
	  	Years of
service	 	  	Standard
Hours/year	 	  	Total hours of
service	 	  	Cost/ton	 	  	Cost/ton
per hour	 
	 Chillers
	  	 	20	  	  	 	8,760	  	  	 	175,200	  	  	$	1,000	  	  	$	0.0057	  
	 Cooling towers
	  	 	20	  	  	 	8,760	  	  	 	175,200	  	  	$	500	  	  	$	0.0029	  
	 Air handling units
	  	 	20	  	  	 	8,760	  	  	 	175,200	  	  	$	1,250	  	  	$	0.0071	  
	 Piping & ductwork
	  	 	30	  	  	 	8,760	  	  	 	262,800	  	  	$	600	  	  	$	0.0023	  
	 Controls
	  	 	10	  	  	 	8,760	  	  	 	87,600	  	  	$	900	  	  	$	0.0103	  
		  				  				  				  	  
	  
	 	  	  
	  
	 
		  				  				  				  	$	4,250	  	  	$	0.0283	  

  

																					
	 Return on Investment
	  	ROI goal	 	 	Standard
Hours/year	 	  	Cost/ton	 	  	Aver, Cost/
ton/year	 	  	Cost/ton
per hour	 
	 Chillers
	  	 	6.75	% 	 	 	8760	  	  	$	1,000	  	  	$	67.50	  	  	$	0.0077	  
	 Cooling towers
	  	 	6.75	% 	 	 	8760	  	  	$	500	  	  	$	33.75	  	  	$	0.0039	  
	 Air handling units
	  	 	6.75	% 	 	 	8760	  	  	$	1,250	  	  	$	84.38	  	  	$	0,0096	  
	 Piping & ductwork
	  	 	6.75	% 	 	 	8760	  	  	$	600	  	  	$	40.50	  	  	$	0.0046	  
	 Controls
	  	 	6.75	% 	 	 	8760	  	  	$	900	  	  	$	60.75	  	  	$	0.0069	  
		  				 				  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
		  				 				  	$	4,250	  	  	$	286.88	  	  	$	0.0327	  

  

																	
	 Make up and Blow down Water
	  	Cost/year	 	  	Standard
Hours/year	 	  	Plant tonnes	 	  	Cost/ton
per hour	 
	 Water cost, yr. 2011
	  	$	60,15	  	  	 	8,760	  	  	 	720	  	  	$	0.0096	  

  

													
	 Total Costs
	  	Cost/ton
per hour	 	  	BTU/ton	 	  	Cost of MBTU	 
	 Power consumption
	  	$	0.0674	  	  	 	12,000	  	  	$	5.62	  
	 Depreciation
	  	$	0.0283	  	  	 	12,000	  	  	$	2.35	  
	 Return on Investment
	  	$	0.0327	  	  	 	12,000	  	  	$	2.73	  
	 Make up and Blow down water
	  	$	0.0096	  	  	 	12,000	  	  	$	0.80	  
		  	  
	  
	 	  				  	  
	  
	 
		  	$	0.1380	  	  				  	$	11.50	  
		  	  
	  
	 	  				  	  
	  
	 

  
 H-1-1 

 EXHIBIT I 

INSURANCE REQUIREMENTS 
  

	1.	Tenant’s Insurance. 

 a. Tenant, at its expense, shall obtain and keep in full force and
effect during the Term: 
 i. a policy of commercial general liability insurance on an occurrence basis against claims for
personal injury, bodily injury, death and/or property damage occurring in or about the Complex, under which Tenant is named as the insured and (a) Landlord, (b) Landlord’s property manager, (c) any lender whose loan is secured by
a lien against the Complex, (d) their respective shareholders, members, partners, affiliates and subsidiaries, successors and assigns, and (e) any directors, officers, employees, agents, or contractors of such persons or entities are named
as additional insureds (collectively, the “Landlord Parties”). Such insurance shall provide primary coverage without contribution from any other insurance carried by or for the benefit of the Landlord Parties, and Tenant shall
obtain blanket broad-form contractual liability coverage to insure its indemnity obligations set forth in Section 28 of the Lease Agreement. The minimum limits of liability applying exclusively to the Leased Premises shall be a combined single
limit with respect to each occurrence in an amount of not less than $5,000,000; provided, however, that Landlord shall retain the right to require Tenant to increase such coverage from time to time to that amount of insurance which in
Landlord’s reasonable judgment is then being customarily required by landlords for similar office space in buildings comparable to the Building. The deductible or self insured retention amount for such policy shall not exceed $10,000; 

ii. insurance against loss or damage by fire, and such other risks and hazards as are insurable under then available standard
forms of “Special Form Causes of Loss” or “All Risk” property insurance policies with extended coverage, insuring Tenant’s movable fixtures and movable partitions, telephone and other equipment, computer systems, trade
fixtures, furniture, furnishings, and other items of personal property which are removable without material damage to the Building (“Tenant’s Property”) and all alterations and improvements to the Leased Premises (including the
Leasehold Improvements constructed pursuant to Exhibit G to the Lease Agreement) to the extent such alterations and improvements exceed the cost of the improvements typically performed in connection with the initial occupancy of tenants
in the Building (“Building Standard Installations”), for the full insurable value thereof or replacement cost thereof, having a deductible amount (or self-insured retention amount), not in excess of $25,000; 

iii. during the performance of any alteration made after the Commencement Date, until completion thereof, Builder’s Risk
insurance on an “all risk” basis and on a completed value form including a Permission to Complete and Occupy endorsement, for full replacement value covering the interest of Landlord and Tenant (and their respective contractors and
subcontractors) in all work incorporated in the Building and all materials and equipment in or about the Leased Premises; 

iv. Workers’ Compensation Insurance, as required by law; 

v. Business Interruption Insurance in an amount equal to at least one year’s Rent; and 

vi. such other insurance in such amounts as the Landlord Parties may reasonably require from time to time. 

b. All insurance required to be carried by Tenant (i) shall contain a provision that (x) no act or omission of Tenant shall affect
or limit the obligation of the insurance company to pay the amount of any loss sustained, and (y) it shall be noncancellable and/or no material change in coverage shall be made thereto unless the Landlord Parties receive thirty
(30) days’ prior notice of the same via US mail, and (ii) shall be effected under valid and enforceable policies issued by reputable insurers permitted to do business in the State of Texas and rated in Best’s Insurance Guide, or
any successor thereto as having a “Best’s Rating” of at least “A-” and a “Financial Size Category” of at least “X” or, if such ratings are not then in effect, the equivalent thereof or such other
financial rating as Landlord may at any time consider appropriate. 

  
 I-1 

 c. On or prior to the Commencement Date, Tenant shall deliver to Landlord appropriate policies of
insurance, including evidence of waivers of subrogation required to be carried pursuant to this Exhibit I and that the Landlord Parties are named as additional insureds (the “Policies”). Evidence of each renewal or
replacement of the Policies shall be delivered by Tenant to Landlord at least ten (10) days prior to the expiration of the Policies. In lieu of the Policies, Tenant may deliver to Landlord a certification from Tenant’s insurance company
(on the form currently designated “Acord 27” (Evidence of Property Insurance) and “Acord 25-S” (Certificate of Liability Insurance), or the equivalent, provided that attached thereto
is an endorsement to Tenant’s commercial general liability policy naming the Landlord Parties as additional insureds) which shall be binding on Tenant’s insurance company, and which shall expressly provide that such certification conveys
to the Landlord Parties all the rights and privileges afforded under the Policies as primary insurance. Tenant will notify Landlord immediately upon receipt of any notice from its insurance carrier of cancellation or non-renewal of the coverages
required under this Lease Agreement. 
  

	2.	Landlord’s Insurance. 

 a. Landlord shall keep the Building insured against damage and
destruction by fire, vandalism, and other perils in the amount of the full replacement value of the Building (as determined for insurance purposes) as the value may exist from time to time, exclusive of foundations and footings, or such lesser
amount as will avoid coinsurance. 
 b. Landlord shall maintain contractual and commercial general liability insurance, including bodily
injury and property damage, with a minimum combined single limit of liability of $1,000,000 for bodily injury or death of any person occurring in or about the Building and $3,000,000 for injury, death, or damages resulting to more than one person in
any one occurrence. 
 c. Notwithstanding the foregoing, in the event Landlord is an institutional owner, then Landlord may elect to
self-insure with respect to the insurance coverages required by the terms of the Lease Agreement. 
  

	3.	Waiver of Subrogation. 

 Landlord and Tenant shall each procure an appropriate clause in or
endorsement to any property insurance covering the Complex and personal property, fixtures and equipment located therein, wherein the insurer waives subrogation or consents to a waiver of right of recovery, and Landlord and Tenant agree not to make
any claim against, or seek to recover from, the other for any loss or damage to its property or the property of others resulting from fire or other hazards to the extent covered by the property insurance that was required to be carried by that party
under the terms of the Lease Agreement. Tenant acknowledges that Landlord shall not carry insurance on, and shall not be responsible for, (i) damage to any alterations or improvements exceeding Building Standard Installations,
(ii) Tenant’s Property, and (iii) any loss suffered by Tenant due to interruption of Tenant’s business. 

  
 I-2 

 EXHIBIT J 

PREVIOUSLY GRANTED EXCLUSIVE USES 
  

	1.	A full service health club and fitness facility offering such fitness programs, recreational facilities, personal training and other related services as Tenant may determine which may include, without limitation, the
following primary permitted uses: a jogging track, weight and aerobic training, racquetball and other racquet sports, gymnasiums, basketball, swimming pool, jacuzzi, sauna and whirlpool facilities, steam rooms, aerobics and/or floor exercise,
strength training, cardio fitness training, free weights, exercise machinery and equipment, martial arts, spinning, boxing, yoga, circuit training and personal training. 

 

	2.	A long term acute care hospital. 

  

	3.	A first class delicatessen style sandwich shop. 

  

	4.	A medical facility having in the Building a linear accelerator, CT scan imaging equipment, PET scan imaging equipment and/or MRI equipment, all for oncological diagnosis and treatment purposes. 

  
 J-1 

 EXHIBIT K 

MODIFIED BOMA STANDARD 
 Life Science
Plaza Modified BOMA Standards 
 The following items constitute the “Modified BOMA Standard” as noted in the Lease Agreement. For the items
not addressed in this modification, the BOMA standard BOMA Z65.1-2010 or its successor shall prevail. A copy of the BOMA standards will be available for review in the management office located on the Penthouse floor, suite 1300 at Life
Science Plaza. 
 The following are the modifications to the BOMA standard. Page numbers refer o the original BOMA document. 

 

	1.	Definition: Major Vertical Penetrations, pg.2 shall read: 

 ‘Major vertical penetrations shall mean stairs,
elevator shafts, flues, pipe shafts, vertical ducts and the like, and their enclosing walls. Atria, light-wells and similar penetrations above the finished floor are included in this definition. Not included, however, are vertical penetrations built
for the private use of a tenant occupying office areas. These major vertical penetrations shall be considered private. Exclusive use of these spaces shall be directed by the Owner. If the tenant uses part of any or all of the vertical penetrations,
the area used shall viewed as leasable/rentable space. Not withstanding the above, structural columns, openings for vertical electrical cable or telephone distribution are not considered to be major vertical penetrations.’ 

 

	2.	Definition: Office Area, pg.2 shall read: 

 ‘Office area shall mean the area where a tenant normally houses
personnel, furniture, equipment and/or other items for the exclusive use of the tenant.’ 
  

	3.	Definition: Measuring Usable Area, pg.16 shall read: 

 ‘Usable area of an interior office area, interior
store area or interior building common area shall be computed by the measuring the area enclosed by: the center line of the corridor and other permanent walls; tenant spaces abutting building common areas are measured to the centerline of walls that
separate them; the dominant portion or a major vertical penetration; and the center of partitions that separate the area being measured from adjoining office areas, store areas and/or building common areas.’ 

 

	4.	Definition: Calculating Store Area, pg.20 shall read: 

 ‘Store area shall be computed by measuring the area
enclosed by: the building line in the case of all exterior outside face/ façade wall surfaces; the center-line surface of the store area side of the corridor and other permanent walls; and the center of interior partitions that separate the
store area from adjoining interior store areas, interior office areas and/or interior building common areas’. 

  
 K-1 

 EXHIBIT L 

LIST OF PREVIOUSLY GRANTED RENEWAL OPTIONS, EXPANSION OPTIONS, 

RIGHTS OF FIRST OFFER AND RIGHTS OF FIRST REFUSAL, 
  

	1.	Renewal Option granted to Houston Diagnostic Cath Lab, LP 

  
 L-1 

 EXHIBIT M 

FORM OF SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT 

SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT 

MassMutual Loan No. 0642101 
 Massachusetts
Mutual Life Insurance Company 
 c/o Cornerstone Real Estate Advisers 

One Financial Plaza 
 Hartford, Connecticut 06103 

Attention: Finance Group Loan Servicing 
 Re: Life Science Plaza
located at 2130 West Holcombe Boulevard, Houston, Texas 77030 
 The undersigned, Bellicum Pharmaceuticals, Inc.,
(“Tenant”) understands that Massachusetts Mutual Life Insurance Company (“Lender”) has made or will be making a loan (the “Loan”) to Sheridan Hills Developments L.P.
(“Landlord”) secured by a mortgage or deed of trust (the “Mortgage”) encumbering the real property (the “Property”) described on Exhibit A, attached hereto and made a part hereof.
Tenant and Landlord entered into a lease agreement (the “Lease”) dated June 1, 2012 by which Tenant leased from Landlord certain premises commonly known as Suite 850 located on the eighth (8th) floor of that certain medical office building located at 2130 West Holcombe Boulevard, Houston, Harris County, Texas 77030 (the “Leased Premises”), and constituting a portion
of the Property. Tenant desires to be able to obtain the advantages of the Lease and occupancy thereunder in the event of foreclosure of the Mortgage and Lender wishes to have Tenant confirm the priority of the Mortgage over the Lease. 

NOW, THEREFORE, in consideration of the mutual covenants and conditions set forth herein, the parties hereto agree as follows: 

 

	1.	Tenant hereby subordinates all of its right, title and interest under the Lease to the lien, operation and effect of the Mortgage s (as the same may be modified and/or extended from time to time) now or hereafter in
force against the Property, and to any and all existing and future advances made under such Mortgage. 

  

	2.	In the event that Lender becomes the owner of the Property by foreclosure, deed in lieu of foreclosure, or otherwise, Tenant agrees to unconditionally attorn to Lender and to recognize it as the owner of the
Property and the Landlord under the Lease. The Lender agrees not to terminate the Lease or disturb or interfere with Tenant’s possession of the Leased Premises during the term of the Lease, or any extension or renewal thereof, so long as
Tenant is not in default under the Lease beyond applicable notice, grace and cure periods, if any. 

  

	3.	Tenant agrees to commence paying all rents, revenues and other payments due under the Lease directly to Lender after Lender notifies Tenant that Lender is the owner and holder of the Loan and is invoking Lender’s
rights under the Loan documents to directly receive from Tenant all rents, revenues and other payments due under the Lease. By making such payments to Lender, Tenant shall be deemed to have satisfied all such payment obligations to Landlord under
the Lease. 

  

	4.	This Agreement shall inure to the benefit of and be binding upon Lender’s affiliates, agents, co-lenders and participants, and each of their respective successors and assigns (each a “Lender Party”
and collectively, the “Lender Parties”). 

  
 M-1 

 IN WITNESS WHEREOF, the parties hereto have caused this Subordination, Non-Disturbance and
Attornment Agreement to be duly executed as of the      day of June, 2012. 
  

					
	TENANT:
	
	Bellicum Pharmaceuticals, Inc.
		
	By:	 	  

	Name:	 	  

	Title:	 	  

	
	LANDLORD:
	
	 Sheridan Hills Developments L.P.,
 a
Texas limited partnership

		
	By:	 	Pouncet Sheridan Inc., an Ontario,
		 	Canada corporation, its general partner
			
		 	By:	 	  

		 	Name:	 	  

		 	Title:	 	  

	
	LENDER:
	
	MASSACHUSETTS MUTUAL LIFE INSURANCE COMPANY
	
	By: Cornerstone Real Estate Advisers LLC,
	its authorized agent
			
		 	By:	 	  

		 		 	Name: 
		 		 	Title:

  
 M-2 

 NOTARY ACKNOWLEDGEMENTS 

 

			
	STATE OF                            	  	)
		  	) ss.
	COUNTY OF                        	  	)

 On this, the day of June, 2012, before me, the undersigned party, personally appeared
                                         who
acknowledged himself/herself to be the                              of Bellicum Pharmaceuticals, Inc., a
Delaware corporation, and that he/she as such                     , being authorized to do so, executed the foregoing Subordination, Non-disturbance
and Attornment Agreement for the purposes therein contained by signing the name of the                      by himself/herself as
                                        . 

IN WITNESS WHEREOF, I hereunto set my hand and official seal. 

 

	
	  

	Notary Public
	My Commissions Expires:

  

			
	STATE OF                            	  	)
		  	) ss.
	COUNTY OF                        	  	)

 On this, the      day of June, 20    , before me, the undersigned
party, personally appeared
                                         who
acknowledged himself/herself to be the                             
of                            , a
                            , and that he/she as such
                    , being authorized to do so, executed the foregoing Subordination, Non-disturbance and Attornment Agreement for the purposes
therein contained by signing the name of the                      by himself/herself as
                            . 

IN WITNESS WHEREOF, I hereunto set my hand and official seal. 

 

	
	  

	Notary Public
	My Commissions Expires:

  

			
	STATE OF                            	  	)
		  	) ss.
	COUNTY OF                        	  	)

 On this, the      day of June, 20    , before me, the undersigned
party, personally appeared
                                         who
acknowledged himself/herself to be the                              of Cornerstone Real Estate Advisoers LLC,
a Delaware limited liability company, and that he/she as such                              , being authorized
to do so, executed the foregoing Subordination, Non-disturbance and Attornment Agreement for the purposes therein contained by signing the name of the corporation by himself/herself as
                                        . 

IN WITNESS WHEREOF, I hereunto set my hand and official seal. 

 

	
	  

	Notary Public

 My Commissions Expires: 

  
 M-3 

 EXHIBIT A 

LEGAL DESCRIPTION 
 All that certain
2.3391 acres being all of Restricted Reserve “A”, Block 1, Twenty-One Thirty West Holcombe Boulevard Replat No. 1 according to the plat thereof as filed in Film Code Number 595196, Harris County Map Records, in the P. W. Rose Survey,
Abstract - 645, Houston, Harris County, Texas, and being more particularly described by metes and bounds as follows (bearings based on Texas Coordinate System of 1983, South Central Zone); 

Commencing at Harris County Floodplain Reference Mark Number 040110 being a brass disc stamped “040110” having published coordinates of (X:
3,110,377.78) and (Y: 13,820,307.50) from which Harris County Floodplain Reference Mark Number 040115 being a brass disc stamped “D100 BM16” bears S 70° 42’ 24” W - 1,730.12’ for reference; Thence N 36° 12’
56” W - 1,995.95’ to a found 3/4” iron pipe with cap (stamped C.L. DAVIS RPLS 4464) marking the southeast corner of said Restricted Reserve “A” from which a found 3/4” iron pipe bears N 79°
32’ 53” E - 0.69’ for reference and marking the POINT OF BEGINNING of herein described tract; 
 1. Thence S 87° 49’
11” W - 932.20’ with the north right-of-way line of West Holcombe Boulevard (120’ wide) to a found 1” iron pipe marking the southwest corner of said Restricted Reserve “A”; 

2. Thence N 02° 10’ 49” W - 104.62’ with the east right-of-way line of Mont Clair Drive (60’ wide) to a 1” pinch top pipe marking
the southwest corner of Lot 22, Block 7, Replat of Southgate Addition Section No. 3 according to the plat thereof as filed in Volume 26, Page 16, Harris County Map Records; 

3. Thence N 87° 52’ 11” E - 798.90’ north line of said Reserve “A” to a found 5/8” iron rod for corner; 

4. Thence N 59° 45’ 09” E - 151.07’ with the south line of Lots 9 - 11, Block 7 of said Replat of Southgate Addition, Section No. 3 to
a found 5/8’ iron rod for corner; 
 5. Thence S 02° 10’ 49” E - 175.00’ with the west line of that certain tract described in a
deed dated 06-301986 from Miller Hotel Development, Incorporated to Burger King Corporation as filed in Official Records of Real Property of Harris County at Clerk’s File Number K-700805, Film Code 056-71-1646 to the POINT OF BEGINNING and
containing 2.3391 (101,892 square feet) of land more or less. 

  
 M-4

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