Document:

Exhibit 4.8

   

  THE SECURITIES REPRESENTED BY THIS INSTRUMENT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR QUALIFIED UNDER APPLICABLE STATE SECURITIES LAWS AND HAVE BEEN TAKEN FOR INVESTMENT PURPOSES ONLY AND
    NOT WITH A VIEW TO OR FOR SALE IN CONNECTION WITH ANY DISTRIBUTION THEREOF. THE SECURITIES MAY NOT BE SOLD OR OTHERWISE TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION AND QUALIFICATION WITHOUT, EXCEPT UNDER CERTAIN SPECIFIC LIMITED CIRCUMSTANCES, AN
    OPINION OF COUNSEL FOR THE HOLDER OF THIS WARRANT, CONCURRED IN BY COUNSEL FOR THE COMPANY THAT SUCH REGISTRATION AND QUALIFICATION ARE NOT REQUIRED.

   

  [_______________]

   

  WARRANT

  

  

  TO PURCHASE SHARES OF SERIES F PREFERRED STOCK OF

  

  

  CASTLE BIOSCIENCES, INC.

   

  THIS CERTIFIES that, for value received, [__________] (the “Investor”), is entitled, upon the terms and subject to the conditions hereinafter set forth, at any time on or after the date set forth in Section 2 below and on or prior to the
    close of business on the fifth (5th) anniversary of the date hereof (the “Expiration Date”), but not thereafter, to subscribe for and purchase, from CASTLE BIOSCIENCES, INC., a
    Delaware corporation (the “Company”), [_______] shares of the Company’s Series F Preferred Stock (the “Shares”) at a purchase price of $[____] per share (the “Exercise Price”).  The Exercise Price and the number of Shares for which this Warrant is exercisable shall be subject to adjustment as provided herein.  This Warrant is one of the
    Warrants issued pursuant to that certain Second Series F Preferred Stock and Warrant Purchase Agreement of even date herewith by and among the Company and the Investors (as defined therein) (as may be amended from time to time, the ‘‘Purchase Agreement”).

   

  Immediately prior to the closing of the Company’s initial public offering of its Common Stock (the “IPO”), this warrant shall become exercisable for that number of shares of the Company’s Common Stock into which the Shares would then be convertible,
    so long as the Shares, if this warrant has been exercised prior to such offering, would have been converted into shares of the Company’s Common Stock pursuant to the automatic conversion provisions (or otherwise) of the Company’s Seventh Amended and
    Restated Certificate of Incorporation (as the same may be amended from time to time).

   

  1.          Title of Warrant.  Prior to the expiration hereof and subject to compliance with applicable laws, this Warrant and all rights hereunder are transferable, in
      whole or in part, at the office or agency of the Company, referred to in Section 2 hereof, by the registered holder of this Warrant (the “Holder”) in person or by duly authorized attorney, upon surrender of this Warrant together with the Assignment Form annexed hereto properly endorsed; provided that, if not already a party thereto, the transferee will agree in writing to be subject to the terms of the applicable Agreements (as defined in the Purchase Agreement) upon the
      acquisition of any Shares pursuant to the exercise of this Warrant.

  
    
      
 

  

  
  2.         Exercise of Warrant.

   

  (a)          The purchase
      rights represented by this Warrant are exercisable by the Holder, in whole or in part, at any time after the Closing (as defined in Purchase Agreement) and before close of business on the Expiration Date, by the surrender of the following to the
      Company at its office located in Friendswood, Texas (or such other office or agency of the Company as it may designate by notice in writing to the Holder):

   

  (i)          this Warrant;

   

  (ii)         an executed copy of the Notice of Exercise
      annexed hereto; and

   

  (iii)       payment of
      the Exercise Price (by cash or by check or bank draft payable to the order of the Company or by cancellation of indebtedness of the Company to the Holder, if any, at the time of exercise in an amount equal to the aggregate Exercise Price of the
      Shares thereby purchased).

   

  (b)          Upon the
      proper exercise of this Warrant, the Holder shall be entitled to receive a certificate for the number of Shares so purchased.  The Company agrees that if at the time of the surrender of this Warrant and purchase the Holder shall be entitled to
      exercise this Warrant, the Shares so purchased shall be and be deemed to be issued to such holder as the record owner of such Shares as of the close of business on the date on which this Warrant shall have been exercised as aforesaid.

   

  (c)          Certificates
      for the Shares purchased hereunder shall be delivered to the Holder within a reasonable time after the date on which this Warrant shall have been exercised as aforesaid.

   

  (d)          The Company
      covenants that the Shares which may be issued upon the exercise of rights represented by this Warrant will, upon exercise of the rights represented by this Warrant, be fully paid and nonassessable and free from all taxes, liens and charges in respect
      of the issue thereof.

   

  3.          Net Exercise.  Notwithstanding any provisions herein to the contrary, if the fair market value of one Share is greater than the Exercise Price (at the date
      of calculation as set forth below), in lieu of exercising this Warrant by payment as specified in Section 2(a)(iii) hereof, the Holder may elect to receive shares equal to the value (as determined below) of this Warrant (or the portion thereof being
      canceled) by surrender of this Warrant at the principal office of the Company together with the properly endorsed copy of the Notice of Exercise annexed hereto in which event the Company shall issue to the Holder a number of Shares computed using the
      following formula:

   

   X = Y (A-B)

  A

   

  Where 

   

    

  
    	

          	X =	
            the number of Shares to be issued to the Holder;

          

  

  
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          	Y =	
            the number of Shares purchasable under this Warrant or, if only a portion of this Warrant is being exercised, the portion of this Warrant being canceled (at the date of
              such calculation)

          

  

   

  
    	

          	A =	
            the fair market value of one Share (at the date of such calculation)

          

  

   

  
    	

          	B =	
            Exercise Price (as adjusted to the date of such calculation)

          

  

   

  For purposes of the above calculation, the fair market value of one Share shall be determined by the Company’s Board of Directors in good
    faith; provided, however, that in the event that this Warrant is exercised pursuant to this Section 3 in connection with the IPO, the fair
    market value per share shall be the product of (i) the per share offering price to the public of the IPO, and (ii) the number of shares of the Company’s Common Stock into which each Share is convertible at the time of such exercise.

   

  4.          No Fractional Shares or Scrip.  No fractional shares or scrip representing fractional shares shall be issued upon the exercise of this Warrant.  With
      respect to any fraction of a Share called for upon the exercise of this Warrant, an amount equal to such fraction multiplied by the Exercise Price shall be paid in cash to the Holder.

   

  5.          Charges, Taxes and Expenses. Issuance of certificates for the Shares issued upon the exercise of this Warrant shall be made without charge to the Holder for
      any issue or transfer tax or other incidental expense in respect of the issuance of such certificate, all of which taxes and expenses shall be paid by the Company, and such certificates shall be issued in the name of the Holder or in such name or
      names as may be directed by the Holder; provided, however, that in the event certificates for such Shares are to be issued in a name other
      than the name of the Holder, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form attached hereto duly executed by the Holder; and provided further, that upon any transfer involved in the issuance or delivery of any
      certificates for the Shares, the Company may require, as a condition thereto, the payment of a sum sufficient to reimburse it for any transfer tax incidental thereto.

   

  6.          No Rights as Stockholders.  This Warrant does not entitle the Holder to any voting rights or other rights as a stockholder of the Company prior to the
      exercise thereof.

   

  7.          Exchange and Registry of Warrant.  This Warrant is exchangeable, upon the surrender hereof by the Holder at the above-mentioned office or agency of the
      Company, for a new Warrant of like tenor and dated as of such exchange.

   

  The Company shall maintain at the above-mentioned office or agency a registry showing the name and address of the Holder.  This Warrant may
    be surrendered for exchange, transfer or exercise, in accordance with its terms, at such office or agency of the Company, and the Company shall be entitled to rely in all respects, prior to written notice to the contrary, upon such registry.

   

  8.          Loss, Theft, Destruction or Mutilation of Warrant.  Upon receipt by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or
      mutilation of this Warrant, and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it, and upon reimbursement to the Company of all reasonable expenses incidental thereto, and upon surrender and cancellation of
      this Warrant, if mutilated, the Company will make and deliver a new Warrant of like tenor and dated as of such cancellation, in lieu of this Warrant.

  
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  9.           Saturdays, Sundays, Holidays, etc.  If the last or appointed day for the taking of any action or the expiration of any right required or granted herein
      shall be a Saturday or a Sunday or shall be a legal holiday, then such action may be taken or such right may be exercised on the next succeeding day not a legal holiday.

   

  10.          Early Termination and Dilution.

   

  (a)          Merger, Sale of Assets, etc.  If at any time the Company proposes to (i) consolidate with merge with, sell or convey all or substantially all of its assets
      to any other corporation, or effect some other form of reorganization, or (ii) effect a registered public offering of its shares, then the Company shall give the Holder thirty (30) days notice of the proposed effective date of such transaction and if
      this Warrant has not been exercised by the effective date of such transaction this Warrant shall terminate.

   

  (b)          Reclassification, etc.  If the Company at any time shall, by subdivision, combination or reclassification of securities or otherwise, change any of the
      securities to which purchase rights under this Warrant exist into the same or a different number of securities of any class or classes, this Warrant shall thereafter be to acquire such number and kind of securities as would have been issuable as the
      result of such change with respect to the securities which were subject to the purchase rights under this Warrant immediately prior to such subdivision, combination, reclassification or other change.  If shares of the Company’s Series F Preferred
      Stock (the “Series F Preferred”) are subdivided or combined into a greater or smaller number of shares of the Series F
      Preferred, the Exercise Price shall be proportionately reduced in case of subdivision of shares or proportionately increased in the case of combination of shares, in both cases by the ratio which the total number of shares of Series F Preferred to be
      outstanding immediately after such event bears to the total number of shares of Series F Preferred outstanding immediately prior to such event.

   

  (c)          Cash Distributions.  No adjustment on account of cash dividends or interest on the Shares or other securities purchasable hereunder will be made to the
      Exercise Price.

   

  (d)          Authorized Shares.  The Company covenants that during the period in which this Warrant is outstanding and exercisable, it will reserve from its authorized
      and unissued Series F Preferred a sufficient number of shares to provide for the issuance of the Shares.  The Company further covenants that its issuance of this Warrant shall constitute full authority to its officers who are charged with the duty of
      executing stock certificates to execute and issue the necessary certificates for the Shares.

   

  11.          Miscellaneous.

   

  (a)          Issue Date.  The provisions of this Warrant shall be construed and shall be given effect in all respects as if it had been issued and delivered by the
      Company on the date hereof.  This Warrant shall be binding upon any successors or assigns of the Company.  This Warrant shall be governed by and construed under the laws of the State of Delaware, without regard to the conflicts of laws provisions
      thereof.

  
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  (b)          Restrictions.  The Holder acknowledges that the Shares may be subject to transfer and sale restrictions imposed by state and federal securities laws or
      pursuant to Company agreements.  The Holder understands and agrees that all certificates evidencing the shares of stock issuable hereunder may bear the following legend:

   

  “THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
    (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES.  THESE SECURITIES MAY NOT BE OFFERED, SOLD, OR OTHERWISE TRANSFERRED,
    PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO REGISTRATION OR AN EXEMPTION THEREFORM.  THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE ISSUER
    THAT SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION OTHERWISE COMPLIES WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS.”

   

  (c)          Waivers and Amendments.  With the consent of the Record Holders (as defined below) holding rights to purchase more than fifty percent (50%) of the shares
      issuable upon exercise of the then outstanding Series F Warrants (as defined below), the obligations of the Company and the rights of the Record Holders may be waived (either generally or in a particular instance, either retroactively or
      prospectively and either for a specified period of time or indefinitely), and with the same consent the Company may enter into a supplementary agreement for the purpose of adding any provisions to or changing in any manner or eliminating any of the
      provisions of the Warrants; provided, however, that no such waiver or supplemental agreement shall reduce the aforesaid percentage which is required for consent to any waiver or supplemental agreement, without the consent of all of the Record Holders
      of the then outstanding Warrants.  As used in this paragraph 10(c), (i) “Series F Warrants” shall mean the “Series F Warrants” as issued pursuant to and defined in the Purchase Agreement, and (ii) the “Record Holders” shall be the record holders of
      all outstanding Warrants.

   

  (d)          Market Stand-Off Agreement.  The Holder shall not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or
      enter into any hedging or similar transaction with the same economic effect as a sale, any Shares (or other securities) held by such Holder, for a period of time specified by the representative of the underwriters of the Company’s Common Stock (or
      other securities) not to exceed 180 days following the effective date of a registration statement of the Company filed under the Act (or such longer period as necessary to permit compliance with NASD Rule 2711 or NYSE Member Rule 472 and similar or
      successor regulatory rules and regulations).  The Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company and/or the managing underwriter(s) which are consistent with the foregoing or which are
      necessary to give further effect thereto.  In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to the Shares (or other securities) held by such Holder until the end of such period.  The
      underwriters of the Company’s stock are intended third party beneficiaries of this Section 10(d) and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto.

  
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  IN WITNESS WHEREOF, CASTLE BIOSCIENCES, INC, has caused this Stock Purchase Warrant to be executed by its officer thereunto duly authorized
    as of the date first set forth above,

   

  
    	
             

          	
            CASTLE BIOSCIENCES, INC.

          
	
             

          	
             

          	
             

          
	
             

          	
            By 

          	
             

          
	
             

          	
             

          	
             

          
	 	Name: 
	 	
            Title:

          

    

    

    
      	
              AGREED AND ACKNOWLEDGED:

            	 
	 	 	 
	
              [________________]

            	 
	 	 	 
	
              By:

            	 	 
	 	 	 
	
              Name:

            	 	 
	 	

            	 
	
              Title:

            	 	 
	 	 	 
	Address: 	 

      

      

      
        Castle Biosciences, Inc.

        Signature Page To Warrant To Purchase Series F Preferred Stock

        
          
            
 

        

      

    

  

  NOTICE OF EXERCISE

   

  To:          CASTLE BIOSCIENCES, INC.

   

  (1)          The
      undersigned hereby elects to purchase _________ shares of Series F Preferred Stock of CASTLE BIOSCIENCES, INC. pursuant to the terms of the attached Warrant, and tenders herewith payment of the aggregate purchase price of such shares of Series F
      Preferred Stock in full, together with all applicable transfer taxes, if any.

   

  (2)          Please issue a certificate of
      certificates representing said shares of Series F Preferred Stock in the name of the undersigned or in such other name as is specified below:

   

   

  

   

  

  
    	
             

          	
             (Name)

          	
             

          
	
             

          	
             

          	
             

          
	
             

          	
             

          	
             

          
	
             

          	
             (Address)

          	
             

          

  

  

  (3)          The
      undersigned represents that the aforesaid shares of Series F Preferred Stock are being acquired for the account of the undersigned for investment and not with a view to, or for resale in connection with, the distribution thereof and that the
      undersigned has no present intention of distributing or reselling such shares.

  
    	 	 	 
	
            [________________]

          	 
	 	 	 
	
            By:

          	 	 
	 	 	 
	
            Name:

          	 	 
	 	

          	 
	
            Title:

          	 	 
	 	 	 
	Date:	 	 

  

  
    
      
 

  

  
    ASSIGNMENT FORM

     

    (To assign the foregoing warrant, execute this form and supply required information. Do not use this form to purchase shares.)

     

    FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned to

     

     

    

    
      	
              (Please Print)

            

    

    

    

    
      	
              whose address is

            	
               

            

    

    
      (Please Print)

       

    

    
      	
               

            

    

    

    Dated: __________________________________ , 20__

     

    
      	
               

            	
              Holder’s Signature:

            	
               

            
	 	 	 
	 	Holder’s Address:	 
	 	 	 
	 	 	 

    

    

    

    
      	
              Signature Guaranteed:

            	
               

            

    

  

   
    NOTE:  The signature to this Assignment Form must correspond with the name as it appears on the face of the Warrant, without alteration or enlargement or any
      change whatever, and must be guaranteed by a bank or trust company. Officers of corporations and those acting in a fiduciary or other representative capacity should file proper evidence of authority to assign the foregoing Warrant.Exhibit 10.2

     

    CASTLE BIOSCIENCES, INC.

     

    2008 STOCK PLAN

     

    1.           Purposes of the Plan. The purposes of this Plan are to attract and retain the best available personnel for positions of substantial responsibility, to provide additional incentive
        to Employees, Directors and Consultants and to promote the success of the Company’s business. The Plan permits the grant of Options and Restricted Stock as the Administrator may determine.

     

    2.            Definitions. As used herein, the following definitions shall apply:

     

    (a)          “Administrator” means the Board or any of its Committees as shall be administering the Plan in accordance with Section 4 hereof.

     

    (b)          “Applicable Laws” means the requirements relating to the administration of equity compensation plans under U.S. state corporate laws, U.S. federal and state securities laws, the
        Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and the applicable laws of any other country or jurisdiction where Awards are granted under the Plan.

     

    (c)          “Award” means, individually or collectively, a grant under the Plan of Options or Restricted Stock.

     

    (d)          “Award Agreement” means the written or electronic agreement setting forth the terms and provisions applicable to each Award granted under the Plan. The Award Agreement is subject to
        the terms and conditions of the Plan.

     

    (e)          “Board” means the Board of Directors of the Company.

     

    (f)          “Change in Control” means the occurrence of any of the following events:

     

    (i)           Change in Ownership of the Company. A change in the ownership of the Company which occurs on the date that any one person, or more than one person acting as a group (“Person”),
        acquires ownership of the stock of the Company that, together with the stock held by such Person, constitutes more than 50% of the total voting power of the stock of the Company, except that any change in the ownership of the stock of the Company
        as a result of a private financing of the Company that is approved by the Board will not be considered a Change in Control; or

     

    (ii)          Change in Effective Control of the Company. If the Company has a class of securities registered pursuant to Section 12 of the Exchange Act, a change in the effective control of the
        Company which occurs on the date that a majority of members of the Board is replaced during any twelve (12) month period by Directors whose appointment or election is not endorsed by a majority of the members of the Board prior to the date of the
        appointment or election. For purposes of this clause (ii), if any Person is considered to be in effective control of the Company, the acquisition of additional control of the Company by the same Person will not be considered a Change in Control; or

    
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    (iii)         Change in Ownership of a Substantial Portion of the Company’s Assets. A change in the ownership of a substantial portion of the Company’s assets which occurs on the date that any
        Person acquires (or has acquired during the twelve (12) month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value equal to or more than 50% of the
        total gross fair market value of all of the assets of the Company immediately prior to such acquisition or acquisitions. For purposes of this subsection (iii), gross fair market value means the value of the assets of the Company, or the value of
        the assets being disposed of, determined without regard to any liabilities associated with such assets.

     

    For purposes of this Section 2(f), persons will be considered to be acting as a group if they are owners of a corporation that enters
      into a merger, consolidation, purchase or acquisition of stock, or similar business transaction with the Company.

     

    Notwithstanding the foregoing, a transaction shall not be deemed a Change in Control unless the transaction qualifies as a change in
      control event within the meaning of Section 409A of the Code, as it has been and may be amended from time to time, and any proposed or final Treasury Regulations and Internal Revenue Service guidance that has been promulgated or may be promulgated
      thereunder from time to time.

     

    Further and for the avoidance of doubt, a transaction shall not constitute a Change in Control if: (i) its sole purpose is to change the
      state of the Company’s incorporation, or (ii) its sole purpose is to create a holding company that shall be owned in substantially the same proportions by the persons who held the Company’s securities immediately before such transaction.

     

    (g)          “Code” means the Internal Revenue Code of 1986, as amended. Any reference to a section of the Code herein shall be a reference to any successor or amended section of the Code.

     

    (h)          “Committee” means a committee of Directors or of other individuals satisfying Applicable Laws appointed by the Board, or by the compensation committee of the Board, in accordance
        with Section 4 hereof.

     

    (i)           “Common Stock” means the Common Stock of the Company.

     

    (j)           “Company” means Castle Biosciences, Inc., a Delaware corporation.

     

    (k)          “Consultant” means any person who is engaged by the Company or any Parent or Subsidiary to render consulting or advisory services to such entity.

     

    (l)           “Director” means a member of the Board.

     

    (m)          “Disability” means total and permanent disability as defined in Section 22(e)(3) of the Code.

     

    (n)          “Employee” means any person, including officers and Directors, employed by the Company or any Parent or Subsidiary of the Company. Neither service as a Director nor payment
      of a director’s fee by the Company shall be sufficient to constitute “employment” by the Company.

    
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    (o)          “Exchange Act” means the Securities Exchange Act of 1934, as amended.

     

    (p)          “Exchange Program” means a program under which (i) outstanding Options are surrendered or cancelled in exchange for Options of the same type (which may have lower or higher exercise
        prices and different terms), Options of a different type, and/or cash, and/or (ii) the exercise price of an outstanding Option is reduced. The terms and conditions of any Exchange Program shall be determined by the Administrator in its sole
        discretion.

     

    (q)          “Fair Market Value” means, as of any date, the value of Common Stock determined as follows:

     

    (i)           If the Common Stock is
        listed on any established stock exchange or a national market system, including without limitation the Nasdaq Global Market, the Nasdaq Global Select Market or the Nasdaq Capital Market, its Fair Market Value shall be the closing sales price for
        such stock (or, if no closing sales price was reported on that date, as applicable, on the last trading date such closing sales price was reported) as quoted on such exchange or system on the day of determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable;

     

    (ii)          If the Common Stock is
        regularly quoted by a recognized securities dealer but selling prices are not reported, its Fair Market Value shall be the mean between the high bid and low asked prices for the Common Stock on the day of determination (or, if no bids and asks were
        reported on that date, as applicable, on the last trading date such bids and asks were reported); or

     

    (iii)         In the absence of an
        established market for the Common Stock, the Fair Market Value thereof shall be determined in good faith by the Administrator.

     

    (r)          “Incentive Stock Option” means an Option that by its terms qualifies and is otherwise intended to qualify as an incentive stock option within the meaning of Section 422 of the Code
        and the regulations promulgated thereunder.

     

    (s)          “Nonstatutory Stock Option” means an Option that by its terms does not qualify or is not intended to qualify as an Incentive Stock Option.

     

    (t)          “Option” means a stock option granted pursuant to the Plan.

     

    (u)          “Parent” means a “parent corporation,” whether now or hereafter existing, as defined in Section 424(e) of the Code.

     

    (v)          “Participant” means the holder of an outstanding Award.

     

    (w)          “Plan” means this 2008 Stock Plan.

    
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    (x)          “Restricted Stock” means Shares issued pursuant to a Restricted Stock award under Section 7 of the Plan, or issued pursuant to the early exercise of an Option.

     

    (y)          “Restricted Stock Purchase Agreement” means a written or electronic agreement between the Company and the Participant evidencing the terms and restrictions applying to Shares
        purchased under a Restricted Stock award. The Restricted Stock Purchase Agreement is subject to the terms and conditions of the Plan and the notice of grant.

     

    (z)          “Securities Act” means the Securities Act of 1933, as amended.

     

    (aa)        “Service Provider” means an Employee, Director or Consultant.

     

    (bb)        “Share” means a share of the Common Stock, as adjusted in accordance with Section 11 below.

     

    (cc)        “Subsidiary” means a “subsidiary corporation,” whether now or hereafter existing, as defined in Section 424(f) of the Code.

     

    3.            Stock Subject to the Plan. Subject to the provisions of Section 11 of the Plan, the maximum aggregate number of Shares that may be subject to Awards and sold under the Plan is
        449,010 Shares. The Shares may be authorized but unissued, or reacquired Common Stock.

     

    If an Award expires or becomes unexercisable without having been exercised in full, or is surrendered pursuant to an Exchange Program,
      the unpurchased Shares that were subject thereto shall become available for future grant or sale under the Plan (unless the Plan has terminated). However, Shares that have actually been issued under the Plan, upon exercise of an Award, shall not be
      returned to the Plan and shall not become available for future distribution under the Plan, except that if unvested Shares of Restricted Stock are repurchased by the Company at their original purchase price, such Shares shall become available for
      future grant under the Plan. Notwithstanding the foregoing and, subject to adjustment provided in Section 11, the maximum number of Shares that may be issued upon the exercise of Incentive Stock Options shall equal the aggregate Share number stated
      in the first paragraph of this Section, plus, to the extent allowable under Section 422 of the Code, any Shares that become available for issuance under the Plan under this second paragraph of this Section.

     

    4.            Administration of the Plan.

     

    (a)          Administrator. The Plan shall be administered by the Board or a Committee appointed by the Board, which Committee shall be constituted to comply with Applicable Laws.

     

    (b)          Powers of the Administrator. Subject to the provisions of the Plan and, in the case of a Committee, the specific duties delegated by the Board to such Committee, and subject to the
        approval of any relevant authorities, the Administrator shall have the authority in its discretion:

     

    (i)           to determine the Fair
        Market Value;

     

      

    (ii)          to select the Service
        Providers to whom Awards may from time to time be granted hereunder;

    
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    (iii)         to determine the number of
        Shares to be covered by each such Award granted hereunder;

     

    (iv)         to approve forms of
        agreement for use under the Plan;

     

    (v)          to determine the terms and
        conditions of any Award granted hereunder. Such terms and conditions include, but are not limited to, the exercise price, the time or times when Awards may be exercised (which may be based on performance criteria), any vesting acceleration or
        waiver of forfeiture restrictions, and any restriction or limitation regarding any Award or the Common Stock relating thereto, based in each case on such factors as the Administrator, in its sole discretion, shall determine;

     

    (vi)         to institute an Exchange
        Program;

     

    (vii)        to prescribe, amend and
        rescind rules and regulations relating to the Plan, including rules and regulations relating to sub-plans established for the purpose of satisfying applicable foreign laws;

     

    (viii)       to modify or amend each
        Award (subject to Section 19(c) of the Plan) including but not limited to the discretionary authority to extend the post-termination exercise period of Awards and to extend the maximum term of an Option (subject to Section 6(a) regarding Incentive
        Stock Options);

     

    (ix)         to authorize any person to
        execute on behalf of the Company any instrument required to effect the grant of an Award previously granted by the Administrator; and

     

    (x)          to construe and interpret
        the terms of the Plan and Awards granted pursuant to the Plan.

     

    (c)          Effect of Administrator’s Decision. All decisions, determinations and interpretations of the Administrator shall be final and binding on all Participants.

     

    5.            Eligibility. Nonstatutory Stock Options and Restricted Stock may be granted to Service Providers. Incentive Stock Options may be granted only to Employees.

     

    6.            Stock Options.

     

    (a)          Term of Option. The term of each Option shall be stated in the Award Agreement; provided, however, that the term shall be no more than ten (10) years from the date of grant
        thereof. In the case of an Incentive Stock Option granted to a Participant who, at the time the Option is granted, owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or
        Subsidiary, the term of the Option shall be five (5) years from the date of grant or such shorter term as may be provided in the Award Agreement.

    
      -5-

      
        
 

    

    (b)          Option Exercise Price and Consideration.

    

     

    (i)           Exercise Price. The per share exercise price for the Shares to be issued upon exercise of an Option shall be such price as is determined by the Administrator, but shall be subject
        to the following:

     

    (A)          In the case of an Incentive
        Stock Option

     

    a)          granted to an Employee who,
        at the time of grant of such Option, owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the exercise price shall be no less than one hundred and ten percent
        (110%) of the Fair Market Value per Share on the date of grant.

     

    b)          granted to any other
        Employee, the per Share exercise price shall be no less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant.

     

    (B)          In the case of a
        Nonstatutory Stock Option, the per Share exercise price shall be no less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant.

     

    (C)          Notwithstanding the
        foregoing, Options may be granted with a per Share exercise price other than as required above in accordance with and pursuant to a transaction described in Section 424 of the Code.

     

    (ii)           Forms of Consideration. The consideration to be paid for the Shares to be issued upon exercise of an Option, including the method of payment, shall be determined by the
        Administrator (and, in the case of an Incentive Stock Option, shall be determined at the time of grant). Such consideration may consist of, without limitation, (1) cash, (2) check, (3) promissory note, to the extent permitted by Applicable Laws,
        (4) other Shares, provided that such Shares have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which such Option shall be exercised and provided that accepting such Shares, in the sole
        discretion of the Administrator, shall not result in any adverse accounting consequences to the Company, (5) consideration received by the Company under a cashless exercise program implemented by the Company in connection with the Plan, (6) such
        other consideration and method of payment for the issuance of Shares to the extent permitted by Applicable Laws, or (7) any combination of the foregoing methods of payment. In making its determination as to the type of consideration to accept, the
        Administrator shall consider if acceptance of such consideration may be reasonably expected to benefit the Company.

     

    (c)          Exercise of Option.

     

    (i)           Procedure for Exercise; Rights as a Stockholder. Any Option granted hereunder shall be
        exercisable according to the terms hereof at such times and under such conditions as determined by the Administrator and set forth in the Award Agreement. An Option may not be exercised for a fraction of a Share.

     

    An Option shall be deemed exercised when the Company receives (i) written or electronic notice of exercise (in accordance with the Award
      Agreement) from the person entitled to exercise the Option, and (ii) full payment for the Shares with respect to which the Option is exercised, together with any applicable withholding taxes. Full payment may consist of any consideration and method
      of payment authorized by the Administrator and permitted by the Award Agreement and the Plan. Shares issued upon exercise of an Option shall be issued in the name of the Participant or, if requested by the Participant, in the name of the Participant
      and his or her spouse. Until the Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or receive dividends or any other rights as a stockholder
      shall exist with respect to the Shares, notwithstanding the exercise of the Option. The Company shall issue (or cause to be issued) such Shares promptly after the Option is exercised. No adjustment shall be made for a dividend or other right for
      which the record date is prior to the date the Shares are issued, except as provided in Section 11 of the Plan.

    
      -6-

      
        
 

    

    Exercise of an Option in any manner shall result in a decrease in the number of Shares thereafter available, both for purposes of the
      Plan and for sale under the Option, by the number of Shares as to which the Option is exercised.

     

    (ii)          Termination of Relationship as a Service Provider. If a Participant ceases to be a Service Provider, such Participant may exercise his or her Option within such period of time as
        is specified in the Award Agreement, to the extent that the Option is vested on the date of termination (but in no event later than the expiration of the term of the Option as set forth in the Award Agreement). In the absence of a specified time in
        the Award Agreement, the Option shall remain exercisable for three (3) months following the Participant’s termination. Unless the Administrator provides otherwise, if on the date of termination the Participant is not vested as to his or her entire
        Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Participant does not exercise his or her Option within the time specified by the Administrator, the Option shall terminate, and
        the Shares covered by such Option shall revert to the Plan.

     

    (iii)          Disability of Participant. If a Participant ceases to be a Service Provider as a result of the Participant’s Disability, the Participant may exercise his or her Option within such
        longer period of time as is specified in the Award Agreement, to the extent the Option is vested on the date of termination (but in no event later than the expiration of the term of such Option as set forth in the Award Agreement). In the absence
        of a specified time in the Award Agreement, the Option shall remain exercisable for twelve (12) months following the Participant’s termination. Unless the Administrator provides otherwise, if on the date of termination the Participant is not vested
        as to his or her entire Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Participant does not exercise his or her Option within the time specified herein, the Option shall
        terminate, and the Shares covered by such Option shall revert to the Plan.

     

    (iv)          Death of Participant. If a Participant dies while a Service Provider, the Option may be exercised within such longer period of time as is specified in the Award Agreement, to the
        extent that the Option is vested on the date of death (but in no event later than the expiration of the term of such Option as set forth in the Award Agreement) by the Participant’s designated beneficiary, provided such beneficiary has been
        designated prior to the Participant’s death in a form acceptable to the Administrator. If no such beneficiary has been designated by the Participant, then such Option may be exercised by the personal representative of the Participant’s estate or by
        the person(s) to whom the Option is transferred pursuant to the Participant’s will or in accordance with the laws of descent and distribution. In the absence of a specified time in the Award Agreement, the Option shall remain exercisable
      for twelve (12) months following the Participant’s termination. If, at the time of death, the Participant is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall immediately revert to the Plan. If
      the Option is not so exercised within the time specified herein, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan.

    
      -7-

      
        
 

    

    (v)          Incentive Stock Option Limit. Each Option shall be designated in the Award Agreement as either an Incentive Stock Option or a Nonstatutory Stock Option. However, notwithstanding
        such designation, to the extent that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock Options are exercisable for the first time by the Participant during any calendar year (under all plans of the Company and any
        Parent or Subsidiary) exceeds one hundred thousand dollars ($100,000), such Options shall be treated as Nonstatutory Stock Options. For purposes of this Section 6(c)(v), Incentive Stock Options shall be taken into account in the order in which they
        were granted. The Fair Market Value of the Shares shall be determined as of the time the Option with respect to such Shares is granted.

     

    7.            Restricted Stock.

     

    (a)          Rights to Purchase. Restricted Stock may be issued either alone, in addition to, or in tandem with other awards granted under the Plan and/or cash awards made outside of the Plan.
        After the Administrator determines that it shall offer Restricted Stock under the Plan, it shall advise the offeree in writing or electronically of the terms, conditions and restrictions related to the offer, including the number of Shares that
        such person shall be entitled to purchase, the price to be paid (if any), and the time within which such person must accept such offer.

     

    (b)          Repurchase Option. Unless the Administrator determines otherwise, the Restricted Stock Purchase Agreement shall grant the Company a repurchase option exercisable within ninety (90)
        days of the voluntary or involuntary termination of the purchaser’s service with the Company for any reason (including death or Disability). Unless the Administrator provides otherwise, the purchase price for Shares repurchased pursuant to the
        Restricted Stock Purchase Agreement shall be the original price paid by the purchaser and may be paid by cancellation of any indebtedness of the purchaser to the Company. The repurchase option shall lapse at such rate as the Administrator may
        determine.

     

    (c)          Other Provisions. The Restricted Stock Purchase Agreement shall contain such other terms, provisions and conditions not inconsistent with the Plan as may be determined by the
        Administrator in its sole discretion.

     

    (d)          Rights as a Stockholder. Once the Restricted Stock is purchased or otherwise issued, the purchaser shall have rights equivalent to those of a stockholder and shall be a stockholder
        when his or her purchase is entered upon the records of the duly authorized transfer agent of the Company. No adjustment shall be made for a dividend or other right for which the record date is prior to the date the Restricted Stock is purchased or
        otherwise issued, except as provided in Section 11 of the Plan.

    
      -8-

      
        
 

    

    8.            Tax Withholding. Prior to the delivery of any Shares pursuant to an Award (or exercise thereof), the Company shall have the power and the right to deduct or withhold, or require a
        Participant to remit to the Company, an amount sufficient to satisfy federal, state, local, foreign or other taxes (including the Participant’s FICA obligation) required to be withheld with respect to such Award (or exercise thereof). The
        Administrator, in its sole discretion and pursuant to such procedures as it may specify from time to time, shall determine in what manner it shall allow a Participant to satisfy such tax withholding obligation and may permit the Participant to
        satisfy such tax withholding obligation, in whole or in part by one (1) or more of the following: (a) paying cash (or by check), (b) electing to have the Company withhold otherwise deliverable Shares having a Fair Market Value equal to the minimum
        amount statutorily required to be withheld, or (c) selling a sufficient number of such Shares otherwise deliverable to a Participant through such means as the Company may determine in its sole discretion (whether through a broker or otherwise)
        equal to the minimum amount statutorily required to be withheld.

     

    9.            Limited Transferability of Awards. Unless determined otherwise by the Administrator, Awards may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any
        manner other than by will or the laws of descent and distribution, and may be exercised during the lifetime of the Participant, only by the Participant.

     

    10.          Leaves of Absence; Transfers.

     

    (a)          Unless the Administrator
        provides otherwise, or except as otherwise required by Applicable Laws, vesting of Awards granted hereunder shall be suspended during any unpaid leave of absence.

     

    (b)          A Service Provider shall not
        cease to be a Service Provider in the case of (i) any leave of absence approved by the Company, or (ii) transfers between locations of the Company or between the Company, its Parent, any Subsidiary, or any successor.

     

    (c)          For purposes of Incentive
        Stock Options, no such leave may exceed three (3) months, unless reemployment upon expiration of such leave is guaranteed by statute or contract. If reemployment upon expiration of a leave of absence approved by the Company is not so guaranteed,
        then six (6) months following the first (1st) day of such leave, any Incentive Stock Option held by the Participant shall cease to be treated as an Incentive Stock
        Option and shall be treated for tax purposes as a Nonstatutory Stock Option.

    
      -9-

      
        
 

    

    11.          Adjustments; Dissolution or Liquidation; Merger or Change in Control.

     

    (a)          Adjustments. In the event that any dividend or other distribution (whether in the form of cash, Shares, other securities, or other property), recapitalization, stock split, reverse
        stock split, reorganization, merger, consolidation, split-up, spin-off, combination, repurchase, or exchange of Shares or other securities of the Company, or other change in the corporate structure of the Company affecting the Shares occurs, the
        Administrator, in order to prevent diminution or enlargement of the benefits or potential benefits intended to be made available under the Plan, shall adjust the number and class of Shares that may be delivered under the Plan and/or the number,
        class, and price of Shares covered by each outstanding Award.

     

    (b)          Dissolution or Liquidation. In the event of the proposed dissolution or liquidation of the Company, the Administrator shall notify each Participant as soon as practicable prior to
        the effective date of such proposed transaction. To the extent it has not been previously exercised, an Award shall terminate immediately prior to the consummation of such proposed action.

     

    (c)          Merger or Change in Control. In the event of a merger or Change in Control, each outstanding Award shall be treated as the Administrator determines, including, without limitation,
        that each Award be assumed or an equivalent award substituted by the successor corporation or a Parent or Subsidiary of the successor corporation. The Administrator shall not be required to treat all Awards similarly in the transaction.

     

    Notwithstanding the foregoing, in the event of a Change in Control in which the successor corporation does not assume or substitute for
      the Award, the Participant shall fully vest in and have the right to exercise his or her outstanding Awards, including Shares as to which such Award would not otherwise be vested or exercisable, and restrictions on all of the Participant’s Restricted
      Stock shall lapse. In addition, if an Award is not assumed or substituted in the event of a merger or Change in Control, the Administrator shall notify the Participant in writing or electronically that the Award shall be fully vested and exercisable
      for a period of time determined by the Administrator in its sole discretion, and any Award not assumed or substituted for shall terminate upon the expiration of such period for no consideration, unless otherwise determined by the Administrator.

     

    For the purposes of this Section 11(c), the Award shall be considered assumed if, following the merger or Change in Control, the option
      or right confers the right to purchase or receive, for each Share subject to the Award immediately prior to the merger or Change in Control, the consideration (whether stock, cash, or other securities or property) received in the merger or Change in
      Control by holders of Common Stock for each Share held on the effective date of the transaction (and if holders were offered a choice of consideration, the type of consideration chosen by the holders of a majority of the outstanding Shares);
      provided, however, that if such consideration received in the merger or Change in Control is not solely common stock of the successor corporation or its Parent, the Administrator may, with the consent of the successor corporation, provide for the
      consideration to be received upon the exercise of the Award, for each Share subject to the Award, to be solely common stock of the successor corporation or its Parent equal in fair market value to the per share consideration received by holders of
      common stock in the merger or Change in Control.

    
      -10-

      
        
 

    

    12.          Time of Granting Awards. The date of grant of an Award shall, for all purposes, be the date on which the Administrator makes the determination granting such Award, or such later
        date as is determined by the Administrator. Notice of the determination shall be given to each Service Provider to whom an Award is so granted within a reasonable time after the date of such grant.

     

    13.          No Effect on Employment or Service. Neither the Plan nor any Award shall confer upon any participant any right with respect to continuing the Participant’s relationship as a
        Service Provider with the Company, nor shall it interfere in any way with his or her right or the Company’s right to terminate such relationship at any time, with or without cause, and with or without notice.

     

    14.          Conditions Upon Issuance of Shares.

     

    (a)          Legal Compliance. Shares shall not be issued pursuant to the exercise of an Award unless the exercise of such Award and the issuance and delivery of such Shares shall comply with
        Applicable Laws and shall be further subject to the approval of counsel for the Company with respect to such compliance.

     

    (b)          Investment Representations. As a condition to the exercise of an Award, the Administrator may in its discretion require the person exercising such Award to represent and warrant at
        the time of any such exercise that the Shares are being purchased only for investment and without any present intention to sell or distribute such Shares.

     

    15.          Inability to Obtain Authority. The inability of the Company to obtain authority from any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to
        be necessary to the lawful issuance and sale of any Shares hereunder, shall relieve the Company of any liability in respect of the failure to issue or sell such Shares as to which such requisite authority shall not have been obtained.

     

    16.          Reservation of Shares. The Company, during the term of this Plan, shall at all times reserve and keep available such number of Shares as shall be sufficient to satisfy the
        requirements of the Plan.

     

    17.          Stockholder Approval. The Plan shall be subject to approval by the stockholders of the Company within twelve (12) months after the date the Plan is adopted. Such stockholder
        approval shall be obtained in the degree and manner required under Applicable Laws.

     

    18.          Term of Plan. Subject to stockholder approval in accordance with Section 17, the Plan shall become effective upon its adoption by the Board. Unless sooner terminated under Section
        19, it shall continue in effect for a term of ten (10) years from the later of (a) the effective date of the Plan, or (b) the earlier of the most recent Board or stockholder approval of an increase in the number of Shares reserved for issuance
        under the Plan.

     

    19.          Amendment and Termination of the Plan.

     

    (a)          Amendment and Termination. The Board may at any time amend, alter, suspend or terminate the Plan.

    
      -11-

      
        
 

    

    (b)          Stockholder Approval. The Board shall obtain stockholder approval of any Plan amendment to the extent necessary and desirable to comply with Applicable Laws.

     

    (c)          Effect of Amendment or Termination. No amendment, alteration, suspension or termination of the Plan shall impair the rights of any Participant, unless mutually agreed otherwise
        between the Participant and the Administrator, which agreement must be in writing (which may include e-mail) and signed by the Participant and the Company. Termination of the Plan shall not affect the Administrator’s ability to exercise the powers
        granted to it hereunder with respect to Options granted under the Plan prior to the date of such termination.

    
      -12-

      
        
 

    

  

  
  
    

    

     

    CERTIFICATE OF AMENDMENT TO THE

    CASTLE BIOSCIENCES INC. 2008 STOCK PLAN

     

    WHEREAS, Castle Biosciences, Inc., a Delaware corporation (the “Company”), adopted the Company’s 2008 Stock Plan (as amended to date, the
      “Plan”) to, among other things, attract and retain the best available personnel for positions of substantial responsibility, to provide additional incentive to Employees, Directors and Consultants and to promote the success of the Company’s business;
      and

     

    WHEREAS, the Board of Directors and stockholders have authorized the Company to amend the Plan to increase the number of Shares that may
      be issued under the Plan from 1,008,826 to 1,608,826 and have authorized the Administrator to increase the number of Shares reserved for issuance under the Plan, Capitalized terms used but not defined herein shall have the meanings ascribed to such
      terms in the Plan.

     

    NOW, THEREFORE, the undersigned herby certifies that:

     

    
      		1.	
              The first paragraph of Section 3 of the Plan has been amended in its entirety as follows:

            

    

     

    “          3.          Stock Subject to the Plan. Subject to the provisions of Section 11 of the Plan, the maximum
        aggregate number of Shares that may be subject to Awards and sold under the Plan is 1,608,826 Shares, The Shares may be authorized but unissued, or reacquired Common Stock.

     

    2.            The foregoing amendment to
        the Plan was adopted by the Board of Directors of the Company on. July 14, 2015 and approved by stockholders of the Company as of July 14, 2015.

     

    3.            Except as otherwise
        expressly set forth herein, all terms and conditions of the Plan shall remain in full force and effect.

     

    IN WITNESS WHEREOF, the undersigned has hereunto set his hand this 14th day of July, 2015.

     

    
      	
               

            	
              Castle Biosciences, Inc.

            
	
               

            	
               

            	
               

            
	
               

            	
              By:

            	
              /s/ Derek Maetzold

            
	
               

            	
               

            	
              Derek Maetzold

            
	
               

            	
               

            	
              President and Chief Executive Officer

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