Document:

Exhibit
10.21

 

NEITHER
THIS CONVERTIBLE PROMISSORY NOTE NOR ANY SECURITIES THAT MAY BE ISSUED UPON CONVERSION HEREOF HAVE BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR ANY SIMILAR STATE LAW. NO OFFER, SALE OR OTHER DISPOSITION MAY BE EFFECTED EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER SUCH ACT OR LAW, UNLESS SUCH REGISTRATION IS NOT REQUIRED THEREBY. AN OPINION OF COUNSEL FOR THE HOLDER
REASONABLY SATISFACTORY TO THE COMPANY MAY BE REQUIRED TO OFFER, SELL OR OTHERWISE DISPOSE OF THIS CONVERTIBLE PROMISSORY NOTE OR ANY
SECURITIES THAT MAY BE ISSUED UPON CONVERSION HEREOF.

 

CONVERTIBLE
PROMISSORY NOTE

 

	$30,000	February
    23, 2021
	 	Seattle,
    Washington

 

For
value received EMulate Therapeutics, Inc., a Washington corporation formerly known
as Nativis, Inc. (the “Company”), promises to pay to Lucky Good Dog, LLC or its permitted assigns (the “Holder”)
the principal sum of $30,000, with simple interest on the outstanding principal amount at the rate of 10.0% per annum. Interest shall
commence with the date hereof and shall continue on the outstanding principal until paid in full or converted. Interest shall be computed
on the basis of a year of 365 days for the actual number of days elapsed.

 

1.
Notes; Convertible Note Purchase Agreement. This note (this “Note”) is issued pursuant to the terms of
the Convertible Note Purchase Agreement (the “Agreement”) dated as of September 6, 2019 (the “Agreement
Date”) as part of a series of Notes (as defined in the Agreement) to be issued to the person(s) and/or entities listed
on the Schedule of Purchasers thereto (collectively, the “Holders”).

 

2.
Payments; Prepayment. All payments of interest and principal shall be in lawful money of the United States of America and shall be
made pro rata among all the Holders. All payments shall be applied first to accrued interest, and thereafter to principal. The Company
may prepay this Note with the consent of the Company’s Board of Directors and the Majority Holders (as defined below).

 

3.
Certain Definitions. For purposes of this Note, the following terms have the means set forth below. Capitalized terms used but not
defined herein have the meanings ascribed to them in the Agreement.

 

“Common
Stock” means the Company’s Common Stock.

 

“Conversion
Price” means of 85% of the Price Per Share.

 

“Deemed
Liquidation” has the same meaning as provided in Article II, Section 2(b)(iv) of the Restated Articles.

 

“Equity
Securities” means the Company’s capital stock, whether authorized and/or issued on or after the Agreement Date.

 

“Financing”
means an offering of Equity Securities for cash with the principal purpose of raising capital.

 

“Majority
Holders” means the Holders of a majority of the then-outstanding principal balance under the Notes.

 

    	EMulate Therapeutics, Inc.	Confidential	Page 1 of
                                                                                                                                                                                                                                                                                                                                                 4
	Convertible Promissory Note	 	 

     

    

 

“Maturity
Date” means the earlier to occur of: (a) the 24-month anniversary of the Agreement Date and (b) the consummation of a Deemed
Liquidation.

 

“Nonqualified
Financing” means a Financing that is not a Qualified Financing (as defined below).

 

“Outstanding
Balance” means the sum of the unpaid principal balance of this Note and the amount of accrued and unpaid interest on this
Note.

 

“Price
Per Share” means the highest price per share of the Qualified Equity Securities sold in the Qualified Financing to other
investors.

 

“Qualified
Equity Securities” means the Equity Securities sold in a Qualified Financing.

 

“Qualified
Financing” means a Financing: (a) that (i) results in the Company’s receipt of gross cash proceeds of at least $10,000,000,
excluding the conversion of any indebtedness (including any indebtedness evidenced by the Notes) and (ii) is accomplished in one or more
closings as part of a single plan of financing based upon a single set of stock purchase agreements and ancillary documentation; or (b)
as otherwise approved by the Majority Holders. If the Qualified Equity Securities are sold at more than one closing, such Qualified Financing
shall be deemed to be consummated on the date of the earliest closing at which the gross cash proceeds received by the Company, together
with the gross cash proceeds received by the Company at any prior closings, equal or exceed $10,000,000, or on such earlier date as determined
by the Majority Holders.

 

“Restated
Articles” means the Company’s Amended and Restated Articles of Incorporation, as amended and in effect as of the
Agreement Date.

 

4.
Conversion.

 

(a)
Conversion into Capital Stock.

 

(i)
Qualified Financing. If the Company consummates a Qualified Financing prior to the Maturity Date, then, upon the closing of such
Qualifying Financing, the Outstanding Balance shall automatically convert into that number of shares of such Qualified Equity Securities
obtained by dividing the Outstanding Balance by the Conversion Price, rounded down to the nearest whole share. The Qualified Equity Securities
received upon conversion of the Notes shall have rights, preferences, and privileges equal to the other Qualified Equity Securities issued
in the Qualified Financing.

 

(ii)
Voluntary Conversion. At any time the Notes are outstanding prior to the Maturity Date, the Holder may elect to convert the Outstanding
Balance into Equity Securities pursuant either subclause (1) or (2) below by delivering notice of such election to the Company pursuant
to Section 6.5 of the Agreement (a “Voluntary Conversion”).

 

(1)
Nonqualified Equity Securities. The Outstanding Balance may be converted into that number of shares of the Equity Securities issued
in the Company’s most recent Nonqualified Financing prior to the date of conversion (the “Nonqualified Equity Securities”)
obtained by dividing the Outstanding Balance by a conversion price equal to the highest cash price paid for the Nonqualified Equity Securities,
rounded down to the nearest whole share. The Nonqualified Equity Securities received upon conversion of the Notes shall have rights,
preferences, and privileges equal to the other Nonqualified Equity Securities issued in the Nonqualified Financing.

 

    	EMulate Therapeutics, Inc.	Confidential	Page 2 of
                                                                                                                                                                                                                                                                                                                                                 4
	Convertible Promissory Note	 	 

     

    

 

(2)
Common Stock. The Outstanding Balance may be converted into that number of shares of Common Stock obtained by dividing the Outstanding
Balance by a conversion price equal to the fair market value per share of Common Stock as of date of conversion, as determined by the
higher of the price per share for the most recent (A) sale of Common Stock to a third party investor by the Company on or prior to the
date of conversion, or (B) grant of options to purchase Common Stock or similar equity awards to an employee or service provider of the
Company on or prior to the date of conversion, in either case rounded down to the nearest whole share.

 

(iii)
Maturity Date Conversion. In the event the Notes have not been repaid or converted prior to the Maturity Date, then upon the Maturity
Date, the Outstanding Balance shall automatically convert into that number of shares of Common Stock determined by dividing the Outstanding
Balance by a price per share equal to the lesser of (1) the fair market value per share of Common Stock on the Maturity Date, as determined
by the higher of the price per share for the most recent (A) sale of Common Stock to a third party investor by the Company on or prior
to the Maturity Date or (B) grant of options or other similar equity awards to an employee or service provider of the Company to purchase
Common Stock on or prior to the Maturity Date, or (2) $9.00, in any case rounded down to the nearest whole share.

 

(b)
Fractional Shares. Notwithstanding any other provision of this Note, no fractional shares shall be issued upon conversion of this
Note pursuant to Section 4, and the Holder hereby agrees to waive its rights with respect to such fractional share or any payment therefore.
Upon conversion of this Note pursuant to Section 4, the shares of capital stock received will be fully paid and non-assessable.

 

(c)
Shareholder Agreements. Upon conversion of this Note pursuant to Section 4, the Holder has agreed to execute counterpart signature
pages to all applicable shareholder agreements and thereafter be bound by such agreements in the same manner as the other holders of
the Equity Securities into which this Note is converted (including in the case of conversion pursuant to Section 4(a)(i) to be automatically
deemed to have executed such agreements pursuant to an irrevocable power of attorney granted by the Holder in the Agreement).

 

5.
Default. If there shall be any Event of Default hereunder, at the option and upon the declaration of the Majority Holders and upon
written notice to the Company (which election and notice shall not be required in the case of an Event of Default under Section 6(c)
or 6(d)), this Note shall accelerate and all principal and unpaid accrued interest shall become due and payable. The occurrence of any
one or more of the following shall constitute an “Event of Default”:

 

(a)
The Company fails to pay timely any of the principal amount due under this Note on the date the same becomes due and payable or any
accrued interest or other amounts due under this Note on the date the same becomes due and payable;

 

(b)
The Company shall default in its performance of any covenant under the Agreement and such default shall constitute a material breach
of the Agreement;

 

(c)
The Company files any petition or action for relief under any bankruptcy, reorganization, insolvency or moratorium law or any other
law for the relief of, or relating to, debtors, now or hereafter in effect, or makes any assignment for the benefit of creditors or takes
any corporate action in furtherance of any of the foregoing; or

 

(d)
An involuntary petition is filed against the Company (unless such petition is dismissed or discharged within sixty (60) days under
any bankruptcy statute now or hereafter in effect, or a custodian, receiver, trustee, assignee for the benefit of creditors (or other
similar official) is appointed to take possession, custody or control of any property of the Company.

 

    	EMulate Therapeutics, Inc.	Confidential	Page 3 of
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	Convertible Promissory Note	 	 

     

    

 

6.
Waiver. The Company hereby waives demand, notice, presentment, protest and notice of dishonor.

 

7.
Governing Law. This Note shall be governed by and construed under the laws of the State of Washington, as applied to agreements among
Washington residents, made and to be performed entirely within the State of Washington, without giving effect to conflicts of laws principles.

 

8.
Senior Indebtedness. The indebtedness evidenced by this Note is subordinated in right of payment to the prior payment in full of
any Senior Indebtedness. “Senior Indebtedness” means, unless expressly subordinated to or made on a parity
with the amounts due under this Note, all amounts due now or in the future in connection with (a) indebtedness of the Company to banks
or other lending institutions regularly engaged in the business of lending money (excluding venture capital, investment banking or similar
institutions and their affiliates that sometimes engage in lending activities but that are primarily engaged in investments in equity
securities), and (b) any such indebtedness or any debentures, notes or other evidence of indebtedness issued in exchange for such Senior
Indebtedness, or any indebtedness arising from the satisfaction of such Senior Indebtedness by a guarantor.

 

9.
Amendment; Waiver. Any term of this Note may be amended or waived in accordance with the terms of Section 6.6 of the Agreement.

 

10.
Transfer. This Note may be transferred only upon its surrender to the Company for registration of transfer, duly endorsed, or accompanied
by a duly executed written instrument of transfer in form satisfactory to the Company. Thereupon, this Note shall be reissued to, and
registered in the name of, the transferee, or a new Note for like principal amount and interest shall be issued to, and registered in
the name of, the transferee. Interest and principal shall be paid solely to the registered holder of this Note. Such payment shall constitute
full discharge of the Company’s obligation to pay such interest and principal.

 

11.
Titles and Subtitles. The titles and subtitles used in this Note are used for convenience only and are not to be considered in construing
or interpreting this Note.

 

12.
ORAL AGREEMENTS OR ORAL COMMITMENTS TO LOAN MONEY, EXTEND CREDIT, OR TO FORBEAR FROM ENFORCING PAYMENT OF A DEBT ARE NOT ENFORCEABLE
UNDER WASHINGTON LAW.

 

	 	EMulate
    Therapeutics, Inc.
	 	 	 
	 	By:	 
	 	Name:
    	Chris
    E. Rivera
	 	Title:
    	President
    and Chief Executive Officer

 

    	EMulate Therapeutics, Inc.	Confidential	Page 4 of 4
	Convertible Promissory NoteExhibit 10.22

 

NEITHER
THIS CONVERTIBLE PROMISSORY NOTE NOR ANY SECURITIES THAT MAY BE ISSUED UPON CONVERSION HEREOF HAVE BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR ANY SIMILAR STATE LAW. NO OFFER, SALE OR OTHER DISPOSITION MAY BE EFFECTED EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER SUCH ACT OR LAW, UNLESS SUCH REGISTRATION IS NOT REQUIRED THEREBY. AN OPINION OF COUNSEL FOR THE HOLDER
REASONABLY SATISFACTORY TO THE COMPANY MAY BE REQUIRED TO OFFER, SELL OR OTHERWISE DISPOSE OF THIS CONVERTIBLE PROMISSORY NOTE OR ANY
SECURITIES THAT MAY BE ISSUED UPON CONVERSION HEREOF.

 

CONVERTIBLE
PROMISSORY NOTE

 

	$600,000	 	July 20, 2021
	 	 	Seattle,
Washington

 

For
value received EMulate Therapeutics, Inc., a Washington corporation formerly known
as Nativis, Inc. (the “Company”), promises to pay to Lucky Good Dog, LLC or its permitted assigns (the “Holder”)
the principal sum of $600,000 (“Principal Amount”), with simple interest on the outstanding Principal Amount
at the rate of 10.0% per annum. Such interest shall commence with the date hereof and shall continue on the outstanding principal until
paid in full or converted. Interest shall be computed on the basis of a year of 365 days for the actual number of days elapsed.

 

1.
Prior Note. The parties acknowledge and agree that (a) this Note cancels and supersedes in its entirety that certain Promissory Note
dated April 4, 2018, made by the Company in favor of Andrew Daniels (the owner of Holder) in the amount of $500,000 (“Prior
Note”), (b) the Prior Note shall have no force or effect from and after the date of this Note, and (c) the Company shall
have no obligation or liability to Holder or to Andrew Daniels whatsoever under the Prior Note.

 

2.
Additional Payment Obligation. The parties agree, as further consideration for the parties’ mutual agreements under this Note,
that the Company is indebted, and shall be obligated to pay, to Holder an additional amount equal to $ 148,562 (“Additional
Amount”). The Additional Amount shall not be deemed to be either principal or interest under this Note; provided, however,
that for purposes of any conversion election by Holder pursuant to Section 4 below, the Additional Amount shall be treated in the same
way as the Outstanding Balance is treated under such sections.

 

3.
Certain Definitions. For purposes of this Note, the following terms have the meanings set forth below.

 

“Common
Stock” means the Company’s Common Stock.

 

“Conversion
Price” means of 85% of the Price Per Share.

 

“Deemed
Liquidation” has the same meaning as provided in Article II, Section 2(b)(iv) of the Restated Articles.

 

    	EMulate Therapeutics, Inc.
Convertible Promissory Note – Blain Trust
	Confidential	Page 1 of 5

     

    

 

“Equity
Securities” means the Company’s capital stock, whether authorized and/or issued on or after the date of this Note.

 

“Financing”
means any form of transaction resulting in a determination of the Company’s valuation, including but not limited to a merger, SPAC
merger, or any other form of financing, whether debt or common or preferred stock.

 

“Maturity
Date” means the earlier to occur of: (a) December 31, 2022, and (b) the consummation of a Deemed Liquidation.

 

“Outstanding
Balance” means the sum of the unpaid principal balance of this Note and the amount of accrued and unpaid interest on this
Note.

 

“Price
Per Share” means the price per share of the Company’s Equity Securities determined in the Financing.

 

“Restated
Articles” means the Company’s Amended and Restated Articles of Incorporation, as amended and in effect as of the
date of this Note.

 

4.
Conversion.

 

(a)
Conversion into Capital Stock.

 

(i)
Financing. If the Company consummates a Financing prior to the Maturity Date, then the Outstanding Balance shall be converted into
that number of shares of such Equity Securities obtained by dividing the Elected Balance by the Conversion Price, rounded down to the
nearest whole share.

 

(ii)
Other Voluntary Conversion. At any time this Note is outstanding prior to the Maturity Date, the Holder may elect to convert such
part of the Outstanding Balance as the Holder may elect (“Elected Balance”) into Equity Securities by delivering
notice of such election to the Company in writing. The Elected Balance may be converted into that number of shares of Common Stock obtained
by dividing the Elected Balance by a conversion price equal to 85% of the fair market value per share of Common Stock as of date of conversion,
as determined by the higher of the price per share for the most recent (A) sale of Common Stock to a third party investor by the Company
on or prior to the date of conversion, or (B) grant of options to purchase Common Stock or similar equity awards to an employee or service
provider of the Company on or prior to the date of conversion, in either case rounded down to the nearest whole share.

 

(b)
Fractional Shares. Notwithstanding any other provision of this Note, no fractional shares shall be issued upon conversion of this
Note pursuant to Section 4, and the Holder hereby agrees to waive their rights with respect to such fractional share or any payment therefor.
Upon conversion of this Note pursuant to Section 4, the shares of capital stock received will be fully paid and non-assessable.

 

    	EMulate Therapeutics, Inc.
Convertible Promissory Note – Lucky Good Dog
	Confidential	Page 2 of 5

     

    

 

(c)
Shareholder Agreements. The Holder agrees and covenants that at any time and from time to time it will promptly execute and deliver
to the Company such further instruments and documents and take such further action as the Company may reasonably require in order to
carry out the full intent and purpose of this Note and to comply with state or federal securities laws or other regulatory approvals.
Upon conversion of a Note pursuant to Section 4, the Holder agrees to execute counterpart signature pages to all applicable shareholder
agreements and thereafter be bound by such agreements in the same manner as the other holders of the Equity Securities into which such
Note is converted. In the event of a conversion of this Note pursuant to Section 4(a) hereof, the Holder shall automatically be deemed
to have executed such agreements and hereby grants an irrevocable power of attorney to any officer of the Company to execute such agreements
on the Holder’s behalf. This power of attorney shall be deemed to be coupled with an interest.

 

5.
Default. If there shall be any Event of Default hereunder, upon written notice to the Company (which notice shall not be required
in the case of an Event of Default under Section 5(c) or 5(d)), this Note shall accelerate and all principal and unpaid accrued interest
shall become due and payable. The occurrence of any one or more of the following shall constitute an “Event of Default”:

 

(a)
The Company files any petition or action for relief under any bankruptcy, reorganization, insolvency or moratorium law or any other
law for the relief of, or relating to, debtors, now or hereafter in effect, or makes any assignment for the benefit of creditors or takes
any corporate action in furtherance of any of the foregoing; or

 

(b)
An involuntary petition is filed against the Company (unless such petition is dismissed or discharged within sixty (60) days) under
any bankruptcy statute now or hereafter in effect, or a custodian, receiver, trustee, assignee for the benefit of creditors (or other
similar official) is appointed to take possession, custody or control of any property of the Company.

 

6.
Waiver. The Company hereby waives demand, notice, presentment, protest and notice of dishonor.

 

7.
Market Standoff Agreement. The Holder shall not sell, dispose of, transfer, make any short sale of, grant any option for the purchase
of, or enter into any hedging or similar transaction with the same economic effect as a sale, any common stock (or other securities,
including without limitation the Equity Securities) of the Company held by such Purchaser pursuant to this Note, for a period of time
specified in the terms of any Financing following the effective date of a registration statement of the Company filed under the Act in
connection with the Company’s initial public offering or listing on a United States stock exchange. Holder agrees to execute and
deliver such other agreements as may be reasonably requested by the Company and/or the managing underwriter(s) which are consistent with
the foregoing or which are necessary to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose
stop-transfer instructions with respect to such common stock (or other securities) until the end of such period.

 

8.
Governing Law. This Note shall be governed by and construed under the laws of the State of Washington, as applied to agreements among
Washington residents, made and to be performed entirely within the State of Washington, without giving effect to conflicts of laws principles.

 

    	EMulate Therapeutics, Inc.
Convertible Promissory Note – Lucky Good Dog
	Confidential	Page 3 of 5

     

    

 

9.
Senior Indebtedness. The indebtedness evidenced by this Note is subordinated in right of payment to the prior payment in full of
any Senior Indebtedness. “Senior Indebtedness” means, unless expressly subordinated to or made on a parity
with the amounts due under this Note, all amounts due now or in the future in connection with (a) indebtedness of the Company to banks
or other lending institutions regularly engaged in the business of lending money (excluding venture capital, investment banking or similar
institutions and their affiliates that sometimes engage in lending activities but that are primarily engaged in investments in equity
securities), and (b) any such indebtedness or any debentures, notes or other evidence of indebtedness issued in exchange for such Senior
Indebtedness, or any indebtedness arising from the satisfaction of such Senior Indebtedness by a guarantor.

 

10.
Amendment; Waiver. No modification or waiver of any provision of this Note or consent to departure therefrom shall be effective unless
in writing and approved by the Company and the Holder.

 

11.
Transfer. This Note may be transferred only upon its surrender to the Company for registration of transfer, duly endorsed, or accompanied
by a duly executed written instrument of transfer in form satisfactory to the Company. Thereupon, this Note shall be reissued to, and
registered in the name of, the transferee, or a new Note for like principal amount and interest shall be issued to, and registered in
the name of, the transferee. Interest and principal shall be paid solely to the registered holder of this Note. Such payment shall constitute
full discharge of the Company’s obligation to pay such interest and principal.

 

12.
Notices. Any notice required or permitted by this Note shall be given in writing and shall be deemed effectively given (a) upon personal
delivery to the party to be notified, (b) upon confirmation of receipt by fax by the party to be notified, (c) one business day after
deposit with a reputable overnight courier, prepaid for overnight delivery and addressed as set forth in (d) or (d) three days after
deposit with the United States Post Office, postage prepaid, registered or certified with return receipt requested and addressed to the
party to be notified at the address indicated below, or at such other address as such party may designate by 10 days’ advance written
notice to the other party given in the foregoing manner.

 

	 	Address
    of Debtor:	 	EMulate
    Therapeutics, Inc.
	 	 	 	425
    Pontius Avenue North
	 	 	 	Suite
    200
	 	 	 	Seattle,
    WA 98109

 

	 	Address
    of Holder:	 	Lucky
    Good Dog, LLC
	 	 	 	340
    9th Street North
	 	 	 	Unit
    249
	 	 	 	Naples,
    FL 34102

 

13.
Titles and Subtitles. The titles and subtitles used in this Note are used for convenience only and are not to be considered in construing
or interpreting this Note.

 

14.
Entire Agreement. This Note constitutes the full and entire understanding and agreement between the parties with regard to the subject
matter hereof and no party shall be liable or bound to any other party in any manner by any representations, warranties, covenants and
agreements except as specifically set forth herein.

 

    	EMulate Therapeutics, Inc.
Convertible Promissory Note – Lucky Good Dog
	Confidential	Page 4 of 5

     

    

 

15.
ORAL AGREEMENTS OR ORAL COMMITMENTS TO LOAN MONEY, EXTEND CREDIT, OR TO FORBEAR FROM ENFORCING PAYMENT OF A DEBT ARE NOT ENFORCEABLE
UNDER WASHINGTON LAW.

 

	 	EMULATE THERAPEUTICS, INC.
	 	 	 
	 	By:	/s/ Chris
    E. Rivera
	 	Name:	Chris E. Rivera
	 	Title:	President and Chief Executive Officer

 

	HOLDER:	 
	 	 	 
	Lucky Good Dog, LLC	 
	 	 	 
	 	 
	Name:	 Andrew Daniels	 
	Title:
    	Manager	 

 

    	EMulate Therapeutics, Inc.
Convertible Promissory Note – Lucky Good Dog
	Confidential	Page 5 of 5

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