Document:

Form of Separation Agreement and Release dated September 30, 2010.

 Exhibit 10.49 
 SEPARATION AGREEMENT AND RELEASE 
 This Separation Agreement and Release
(the “Agreement”) is made by and between San Jose Water Company (the “Company”), and David A. Green (“Employee”) dated as of September 30, 2010. 

RECITALS 

A. Employee is an employee of the Company, serving as Chief Financial Officer and Treasurer. 

B. Employee serves as an Officer of San Jose Water Company, SJW Land Company, SJW Corp., SJWTX, Inc., and Texas Water Alliance Limited.

 C. The Company and Employee have agreed that Employee shall cease employment with the Company and will cease to serve as an
Officer of San Jose Water Company, SJW Land Company, SJW Corp., SJWTX, Inc., and Texas Water Alliance Limited. 
 NOW THEREFORE,
in consideration of the mutual promises made herein, the Company and Employee (each, a “Party” and collectively, the “Parties”) hereby agree as follows: 
 AGREEMENT 
 1. Separation. The Parties agree that Employee’s
employment with the Company will cease as of September 30, 2010 (the “Separation Date”). By that same date, Employee shall cease to serve as an Officer of San Jose Water Company, SJW Land Company, SJW Corp., SJWTX, Inc., and Texas
Water Alliance Limited and will no longer perform any further duties with such companies or render services in any other capacity to them. Accordingly on the Separation Date, Employee shall incur a separation from service for purposes of
Section 409A of the Internal Revenue Code (“Section 409A”). Employee acknowledges that Company has paid all salary, wages, bonuses, accrued vacation, commissions and any and all other benefits due to Employee through the Separation
Date. 
 2. Consideration. If and only if this Agreement is timely executed by the Employee and not revoked by the
Employee as set forth below, the Company agrees to pay Employee the following amounts which Employee hereby acknowledges and agrees would not otherwise be payable to him in the absence of the general release required of him under this Agreement:

 a. Cash Bonus. A special bonus of Sixty Five Thousand Dollars ($65,000.00), less applicable
withholdings and payable in a lump sum in April, 2011; 

  
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 b. Employee Benefits. The Company shall reimburse Employee for the
COBRA coverage costs he incurs for continued medical and dental care coverage under the Company’s employee group health plans through December 31, 2010. In order to obtain such reimbursement, Employee must submit appropriate evidence to
the Company of each periodic payment of such COBRA coverage costs within thirty (30) days after the required payment date for those coverage costs, and the Company shall within thirty (30) days after such submission reimburse Employee for
that payment. The amount of such COBRA coverage costs eligible for reimbursement in any one calendar year shall not affect the amount of such coverage costs eligible for reimbursement in any other calendar year; and Employee’s right to the
reimbursement of such COBRA coverage costs cannot be liquidated or exchanged for any other benefit. To the extent any such reimbursements constitute taxable income to Employee, those reimbursements will be subject to the Company’s collection of
the applicable withholding taxes. In no event shall the Company reimburse more than $16,500 of such COBRA coverage costs. 
 3.
Outstanding Equity Awards. Employee currently holds restricted stock unit awards granted in accordance with the SJW Corp. Long-Term Incentive Plan. Such restricted stock unit awards will continue to be governed by the terms and conditions of
the Long-Term Incentive Plan and relevant Restricted Stock Unit Issuance Agreements. All vesting of those restricted stock unit awards shall cease on the Separation Date, and those restricted stock unit awards, to the extent unvested at that time,
shall terminate and cease to entitle Employee to any additional shares of SJW Corp. common stock thereunder. 
 4. Return of
Property. Employee shall promptly return to the Company all property of SJW Corp. or its subsidiaries, including, without limitation, keys, pass cards, lap tops, cellular phones, company vehicle, all other company equipment, tangible proprietary
information, documents, books, records, reports, contracts, lists, computer disks (or other computer-generated files or data), or copies thereof, created on any medium, prepared or obtained by Employee in the course of or incident to his employment
with the Company. 
 5. Confidential Information. Employee shall continue to maintain the confidentiality of all
confidential and proprietary information of SJW Corp. or its subsidiaries and as required in the San Jose Water Company Employee Policies and Procedures, of which Employee acknowledged receipt. Specifically, Employee agrees that both during
employment by the Company and after termination, Employee shall keep in confidence and trust all Confidential Information and proprietary information of SJW Corp. or its subsidiaries and of any client, customer, licensor or vendor of SJW Corp. or
its subsidiaries (collectively “the Proprietary Information”), and shall not disclose such Proprietary Information or anything relating to such Proprietary Information without the prior written consent of the Company. 

a. “Confidential Information” includes any information and documents relating to or concerning business
information, business plans, revenue 

  
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plans or projections, business methodology, financial plans, technical information, strategic planning, actual or intended product features, know-how, show-how, processes, formulas, data,
techniques, statistics, specifications, service design, rate plans and pricing, financial information, financial projections, trade secrets, ideas, sketches, drawings, models, software programs, improvements, inventions, techniques, source code,
engineering information, strategies, forecasts, computer programs, copyrightable material, customer lists, clients, methodology, market research, market surveys, distribution plans, patentable inventions, current, future and proposed services or
products and marketing strategies conceived by, owned, created, designed by, or pertaining to SJW Corp. or its subsidiaries, or any client, customer, licensor or vendor of the Company. 

b. At all times, both during the remaining duration of employment and after termination Employee shall not use any
Proprietary Information or anything relating to such Proprietary Information without the prior written consent of the Company, except as strictly necessary to perform the services required by the Company prior to the effective date of your
termination from the Company. All documents, records, magnetic storage media and information thereon, apparatus, equipment and other physical property, whether or not pertaining to Proprietary Information, furnished by the Company or produced by the
Employee or others in connection with the employment with the Company shall be and remain the sole property of the Company and shall be returned to it immediately as and when requested by the Company. 

c. Employee shall return and deliver all such property upon termination of employment and Employee will not retain, remove
or take any such property or any reproduction of such property upon such termination. Without limiting the foregoing, Employee shall return all of Proprietary Information, and all copies of any Proprietary Information, including without limitation
notes, memoranda and other documents concerning the Proprietary Information, to the Company, upon termination of employment and within five business days after request therefore by the Company. 

6. Release of Claims. In consideration of the covenants and promises set forth in this Agreement, Employee forever releases and
discharges the Company and the Company’s officers, directors, employees, agents, parents, investors, stockholders, administrators, affiliates, divisions, subsidiaries, predecessor and successor corporations, and assigns, the Company’s
parent corporation, SJW Corp., and its officers, directors, employees, agents, parents, investors, stockholders, administrators, affiliates, divisions, subsidiaries, predecessor and successor corporations, and assigns, and any affiliated entities of
the Company and/or SJW Corp., including but not limited to SJW Land Company, SJWTX, Inc., and Texas Water Alliance Limited, and those entities’ officers, directors, employees, agents, parents, investors, stockholders, administrators,
affiliates, divisions, subsidiaries, predecessor and successor corporations, and assigns (the “Releasees”), from, and agree not to sue or otherwise initiate legal or dispute resolution proceedings against the Releasees concerning, any
claim, duty, obligation or cause of action relating to any matters of any kind, whether presently known or unknown, 

  
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suspected or unsuspected, that the Employee may possess arising from any omissions, acts or facts that have occurred up until and including the Separation Date of this Agreement, including but
not limited to: 
 a. any and all claims relating to or arising from Employee’s employment relationship with
the Company and the termination of that relationship; 
 b. any and all claims relating to, or arising from,
Employee’s right to purchase, or actual purchase of shares of stock of SJW Corp. whether pursuant to stock options or otherwise, including, without limitation, any claims for fraud, misrepresentation, breach of fiduciary duty, breach of duty
under applicable state corporate law, and securities fraud under any state or federal law; 
 c. any and all
claims for wrongful discharge of employment; termination in violation of public policy; discrimination; harassment; breach of contract, both express and implied; breach of a covenant of good faith and fair dealing, both express and implied;
promissory estoppel; negligent or intentional infliction of emotional distress; negligent or intentional misrepresentation; negligent or intentional interference with contract or prospective economic advantage; unfair business practices; defamation;
libel; slander; disparaging statements; negligence; personal injury; assault; battery; invasion of privacy; false imprisonment; conversion; and workers compensation and disability; 

d. any and all claims for violation of any federal, state or municipal statute, including, but not limited to,
Title VII of the Civil Rights Act of 1964, the Civil Rights Act of 1991, the Age Discrimination in Employment Act of 1967 (the “ADEA”), the Americans with Disabilities Act of 1990, the Fair Labor Standards Act, the Employee
Retirement Income Security Act of 1974, The Worker Adjustment and Retraining Notification Act, Older Workers Benefit Protection Act; the Family and Medical Leave Act; the California Family Rights Act; the California Fair Employment and Housing Act,
and the California Labor Code, including, but not limited to, California Labor Code Sections 1400 – 1408; 

e. any and all claims for violation of the federal, or any state, constitution; 

f. any and all claims arising out of any other laws and regulations relating to employment or employment discrimination;
and 
 g. any and all claims for attorneys’ fees and costs. 

The Parties agree that the release set forth in this section shall be and remain in effect in all respects as a complete general release as to the
matters released. This release does not extend to any obligations incurred under this Agreement. This release also does not release claims that cannot be released as a matter of law, including, but not limited to: (1) Employee’s right to
file a charge with or participate in a charge by the Equal Employment 

  
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Opportunity Commission, or any other local, state, or federal administrative body or government agency that is authorized to enforce or administer laws related to employment, against the Company
(with the understanding that any such filing or participation does not give Employee the right to recover any monetary damages against the Company; Employee’s release of claims herein bars Employee from recovering such monetary relief from the
Company); (2) claims under Division 3, Article 2 of the California Labor Code (which includes California Labor Code section 2802 regarding indemnity for necessary expenditures or losses by employee); (3) claims prohibited from release as
set forth in California Labor Code section 206.5 (specifically “any claim or right on account of wages due, or to become due, or made as an advance on wages to be earned, unless payment of such wages has been made”), (4) claims
relating to payments and benefits to be provided Employee pursuant to the express terms of this Agreement, (5) claims for workers’ compensation benefits or unemployment compensation, (6) health insurance benefits under the
Consolidated Omnibus Budget Reconciliation Act (COBRA) and (7) claims that, as a matter of applicable law, are not waivable or otherwise subject to release. 
 7. Acknowledgment of Waiver of Claims under ADEA. Employee acknowledges that he is waiving and releasing any rights he may have under the ADEA and that this waiver and release is knowing and
voluntary. Employee and the Company agree that this waiver and release does not apply to any rights or claims that may arise under ADEA after the Effective Date of this Agreement. Employee acknowledges that the consideration given for this waiver
and release Agreement is in addition to anything of value to which Employee was already entitled. Employee further acknowledges that he has been advised by this writing that: 

a. He should consult with an attorney prior to executing this Agreement; 

b. He has twenty-one (21) days from the date he was presented with this Agreement within which to consider this
Agreement; 
 c. He has seven (7) days following his execution of this Agreement to revoke this Agreement;

 d. This Agreement shall not be effective until after the revocation period has expired; 

e. Nothing in this Agreement prevents or precludes Employee from challenging or seeking a determination in good faith of
the validity of this waiver under the ADEA, nor does it impose any condition precedent, penalties, or costs for doing so, unless specifically authorized by federal law. 
 In the event Employee signs this Agreement and returns it to the Company in less than the 21-day period identified above, Employee hereby acknowledges that he has freely and voluntarily chosen to waive
the time period allotted for considering this Agreement. 

  
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 8. Civil Code Section 1542. The Parties represent that they are not aware of any
claim they have against each other, other than the claims that are released by this Agreement. The Parties acknowledge that they have been advised by legal counsel and are familiar with the provisions of California Civil Code Section 1542,
which provides as follows: 
 A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN
HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM OR HER MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR. 
 Employee, being aware of said code section, agrees to expressly waive any rights he may have thereunder, as well as under any other statutory or common law principles of similar effect. 

9. No Pending or Future Lawsuits. Each Party represents that it/he has no lawsuits, claims, or actions pending in its/his name, or
on behalf of any other person or entity, against the other Party or any other person or entity referred to herein. Each Party also represents that it/he does not intend to bring any claims on its/his own behalf or on behalf of any other person or
entity against the other Party or any other person or entity referred to herein. Employee further agrees to waive any right to re-employment with the Company. 
 10. Non-Disparagement. The Parties agree that it/he shall make no negative statements to third parties concerning, or take any action that disparages or denigrates the other Party, or its
services, products, reputation, administration, employees, financial status, or operations, or take any action that damages or interferes with any of the other Party’s existing or prospective business relationships. 

11. Confidentiality of Agreement. Until such time as the existence of this Agreement is disclosed by the Company as required by
law, the Parties hereto each agree to maintain in confidence the existence of this Agreement, the contents and terms of this Agreement and the consideration for this Agreement (hereinafter collectively referred to as “Settlement
Information”). During such period of non-disclosure, (i) each Party hereto agrees to take every reasonable precaution to prevent disclosure of any Settlement Information to third parties, and each agrees that there will be no publicity,
directly or indirectly, concerning any Settlement Information and (ii) each Party hereto agrees to take every precaution to disclose Settlement Information only to those employees, officers, directors, attorneys, accountants, governmental
entities, and family members who have a reasonable need to know of such Settlement Information. 
 12. No Cooperation.
The Parties agree that they will not counsel or assist any attorneys or their clients in the presentation or prosecution of any disputes, differences, 

  
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grievances, claims, charges, or complaints by any third party against the other Party to this Agreement and/or any officer, director, employee, agent, representative, stockholder or attorney of
the other Party, unless under a subpoena or other court order to do so. 
 13. Nondisclosure Agreement by the Company.
Unless authorized in writing by Employee, Company agrees that it will make no disclosures concerning the Employee’s employment or other information regarding the Employee except for confirming employment, job title, dates of service, and rate
of pay, plus additional information as, and only as, required pursuant to subpoena or otherwise required by law. 
 14. No
Admission of Liability. The Parties understand and acknowledge that this Agreement constitutes a compromise and settlement of disputed claims. No action taken by the Parties hereto, or either of them, either previously or in connection with this
Agreement shall be deemed or construed to be (a) an admission of the truth or falsity of any claims heretofore made or (b) an acknowledgment or admission by either party of any fault or liability whatsoever to the other party or to any
third party. 
 15. Arbitration. 
 a. The Parties agree that any and all disputes arising out of, relating to, or in connection with this Agreement, the interpretation, validity, construction, performance, breach, or termination hereof or
any of the matters herein released, shall be subject to binding arbitration in Santa Clara County, California in accordance with the National Rules for the Resolution of Employment Disputes then in effect of the American Arbitration Association (the
“Rules”). The Parties agree that the prevailing party in any arbitration shall be entitled to injunctive relief in any court of competent jurisdiction to enforce the arbitration award. The Parties agree that each party in any
arbitration shall be responsible for such party’s costs. 
 b. EMPLOYEE HAS READ AND UNDERSTANDS THIS
SECTION 15, WHICH DISCUSSES ARBITRATION. EMPLOYEE UNDERSTANDS THAT BY SIGNING THIS AGREEMENT, EMPLOYEE AGREES TO SUBMIT ANY CLAIMS ARISING OUT OF, RELATING TO, OR IN CONNECTION WITH THIS AGREEMENT, THE INTERPRETATION, VALIDITY, CONSTRUCTION,
PERFORMANCE, BREACH OR TERMINATION THEREOF, OR ANY OF THE MATTERS HEREIN TO BINDING ARBITRATION, AND THAT THIS ARBITRATION CLAUSE CONSTITUTES A WAIVER OF EMPLOYEE’S RIGHT TO A JURY TRIAL AND RELATES TO THE RESOLUTION OF ALL DISPUTES RELATING TO
ALL ASPECTS OF THIS SEVERANCE AGREEMENT AND RELEASE OF ALL CLAIMS. 
 16. Authority. The Company represents and warrants
that the undersigned has the authority to act on behalf of the Company and to bind the Company and all who may claim through it to the terms and conditions of this Agreement. Employee represents and warrants that he has the capacity to act on his
own behalf and on behalf of all who 

  
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might claim through him to bind them to the terms and conditions of this Agreement. Each Party warrants and represents that there are no liens or claims of lien or assignments in law or equity or
otherwise of or against any of the claims or causes of action released herein. 
 17. Successors and Assigns. Any
references to the Company shall be interpreted to include a reference to any successor or resultant company in the event of a merger or acquisition or sale of substantially all of the Company’s assets. Any such successor or resultant company
shall be and remain liable for all of Company’s responsibilities and obligations hereunder. 
 18. No
Representations. Each party represents that it has had the opportunity to consult with an attorney, and has carefully read and understands the scope and effect of the provisions of this Agreement. Neither party has relied upon any
representations or statements made by the other party hereto which are not specifically set forth in this Agreement. 
 19.
Severability. In the event that any provision hereof becomes or is declared by a court of competent jurisdiction to be illegal, unenforceable or void, this Agreement shall continue in full force and effect without said provision. 

20. Entire Agreement. This Agreement represents the entire agreement and understanding between the Company and Employee concerning
Employee’s employment with, and separation from the Company, and supersedes and replaces any and all prior agreements and understandings concerning Employee’s relationship with the Company and his compensation by the Company. This
Agreement supersedes in its entirety any offer letter or other employment agreement which shall be of no further force or effect. 
 21. No Oral Modification. This Agreement may only be amended in writing signed by Employee and the President or Chief Executive Officer of the Company following approval of such amendment by the
Company’s Board of Directors or the Executive Compensation Committee thereof. 
 22. Governing Law. This Agreement
shall be governed by the internal substantive laws, but not the choice of law rules of the State of California. 
 23.
Effective Date. If Employee timely signs the Agreement within the twenty-one (21) day period provided in section 7 above, Employee has seven (7) days after he signs the Agreement to revoke it. In order to revoke the acceptance of
the agreement effectively, Employee must provide written notice to W. Richard Roth, President and CEO, on or before that date. This Agreement will become effective on the eighth (8th) day after Employee signed this Agreement, so long as it has
been signed by the Employee and has not been revoked by Employee before that date (the “Effective Date”). 

  
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 24. Expiration of Agreement. This Agreement is executable until October 21,
2010 (the “Expiration Date”). This Agreement is null and void if the Company has not received a copy of the Agreement executed by the Employee on or before the Expiration Date. 

25. Counterparts. This Agreement may be executed in counterparts, and each counterpart shall have the same force and effect as an
original and shall constitute an effective, binding agreement on the part of each of the undersigned. 
 26. Voluntary
Execution of Agreement. This Agreement is executed voluntarily and without any duress or undue influence on the part or behalf of the Parties hereto, with the full intent of releasing all claims. The Parties acknowledge that: 

a. They have read this Agreement; 
 b. They have been represented in the preparation, negotiation, and execution of this Agreement by legal counsel of their own choice or that they have voluntarily declined to seek such counsel; 

c. They understand the terms and consequences of this Agreement and of the releases it contains; 

d. They are fully aware of the legal and binding effect of this Agreement; and 

e. This release offer will expire on October 21, 2010 if the Company has not received a copy of the Agreement
executed by Employee as of that date. 
 IN WITNESS WHEREOF, the Parties have executed this Agreement on the respective dates set forth below.

  

							
		 		 	SAN JOSE WATER COMPANY
				
	Dated:     10/20/2010    	 		 	By:	 	 /s/ W. Richard Roth

		 		 		 	W. Richard Roth, President and CEO
			
		 		 	EMPLOYEE
				
	Dated:     10/20/2010    	 		 		 	 /s/ David A. Green

		 		 		 	David A. Green

  
 - 9 -Amended and Restated Change of Control Agreement

 Exhibit 10.28 
 AMENDED AND RESTATED 
 CHANGE OF CONTROL AGREEMENT 

This Amended and Restated Change of Control Agreement (the “Agreement”) is made and entered into by and
between GIANNA M. BOSKO (the “Executive”) and XENOPORT, INC., a Delaware corporation (the “Company”), effective as of
February 25, 2011 (the “Effective Date”). From and following the Effective Date, this Agreement shall replace and supersede that certain Change of Control Agreement between the Executive and the Company dated September 3, 2010
(the “Prior Agreement”). The Company and the Executive desire to amend and restate the terms of the terms of the Prior Agreement to eliminate the tax gross-up payment with respect to the excise tax liability, if any, under
Section 4999 of the Internal Revenue Code of 1986, as amended (the “Code”) related to any excess parachute payment under Section 280G of the Code and to make other clarifying changes. 

RECITALS 
 It is expected that the Company from time to time may consider the possibility of an acquisition by another company or other change of control. The Board of Directors of the Company (the
“Board”) recognizes that such consideration can be a distraction to the Executive and can cause the Executive to consider alternative employment opportunities. The Board has determined that it is in the best interests of the Company
and its stockholders to assure that the Company will have the continued dedication and objectivity of the Executive, notwithstanding the possibility, threat or occurrence of a Change of Control (as defined below) of the Company. 

The Board believes that it is in the best interests of the Company and its stockholders to provide the Executive with an
incentive to continue her employment and to motivate the Executive to maximize the value of the Company upon a Change of Control for the benefit of its stockholders. 

Certain capitalized terms used in the Agreement are defined in Section 5 below. 

The parties hereto agree as follows: 
 1. Term of Agreement. This Agreement shall terminate upon the date that all obligations of the parties hereto with respect to this Agreement have been satisfied. 

2. At-Will Employment. The Company and the Executive acknowledge that the Executive’s employment is and shall continue to be
at-will. If the Executive’s employment terminates for any reason, including (without limitation) any termination prior to a Change of Control, the Executive shall not be entitled to any payments, benefits, damages, awards or compensation other
than as provided by this Agreement, or as may otherwise be available in accordance with written plans or agreements with the Company. 

  
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 3. Termination Following a Change of Control. 

(a) Termination Without Cause or Voluntary Termination For Good Reason. In the event that a Change of Control (as
defined below) of the Company occurs, and during the period beginning on the closing date of the transaction giving rise to such Change of Control and ending twelve (12) months after such closing date, the Executive’s employment with the
Company (or the successor entity in such Change of Control transaction) is either (1) terminated by the Company (or its successor entity) without Cause (as defined below) or (2) terminated by the Executive for Good Reason (as defined
below), then the Executive shall be entitled to receive Termination Benefits (as defined below); provided, however, that in order for the Executive to terminate for Good Reason, (i) the Executive must provide written notice to the
Company (or the successor entity in the Change of Control transaction) of the existence of the Good Reason condition within ninety (90) days following the initial existence of the Good Reason condition, and (ii) the Company (or the
successor entity in the Change of Control transaction) shall not be required to provide Termination Benefits if it remedies the Good Reason condition within a period of thirty (30) days following such notice. 

(b) Payment of Termination Benefits. Notwithstanding anything to the contrary herein, the following provisions
apply to the extent Termination Benefits provided herein are subject to Section 409A of the Code and the regulations and other guidance thereunder and any state law of similar effect (collectively “Section 409A”). Termination
Benefits shall not commence until Executive has a “separation from service” for purposes of Section 409A. If the Executive becomes entitled to receive Termination Benefits pursuant to Section 3(a), the continued payments of base
salary, to the extent of payments made from the date of the Executive’s termination of employment through March 15 of the calendar year following such termination, are intended to constitute separate payments for purposes of
Section 1.409A-2(b)(2) of the Treasury Regulations and thus payable pursuant to the “short-term deferral” rule set forth in Section 1.409A-1(b)(4) of the Treasury Regulations; to the extent such payments are made following said
March 15, they are intended to constitute separate payments for purposes of Section 1.409A-2(b)(2) of the Treasury Regulations made upon an involuntary termination from service and payable pursuant to Section 1.409A-1(b)(9)(iii) of
the Treasury Regulations, to the maximum extent permitted by such provision, with any excess amount being regarded as subject to the distribution requirements of Section 409A(a)(2)(A) of the Code, including, without limitation, the requirement
of Section 409A(a)(2)(B)(i) of the Code that payment be delayed until the earlier of six (6) months after the Executive’s termination of employment if the Executive is a “specified employee” within the meaning of
Section 409A(a)(2)(B)(i) of the Code at the time of such termination, or the Executive’s death. 
 4. Certain
Additional Payments by the Company. 
 If any payment or benefit the Executive would receive pursuant to a
Change of Control from the Company or otherwise would (i) constitute a “parachute payment” within the meaning of Section 280G of the Code (collectively, the “Payment”) and (ii) but for this sentence, be
subject to the excise tax imposed by Section 4999 of the Code or any interest or penalties payable 

  
 2 

 
with respect to such excise tax (such excise tax, together with any such interest and penalties, are hereinafter collectively referred to as the “Excise Tax”), then such Payment
shall be reduced to the Reduced Amount. The “Reduced Amount” shall be either (x) the largest portion of the Payment that would result in no portion of the Payment being subject to the Excise Tax or (y) the largest portion,
up to and including the total, of the Payment, whichever amount, after taking into account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal rate), results in
Executive’s receipt, on an after-tax basis, of the greater economic benefit notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in payments or benefits constituting “parachute
payments” is necessary so that the Payment equals the Reduced Amount, the reduction shall occur in the manner that results in the greatest economic benefit for Executive. If more than one method of reduction will result in the same economic
benefit, the items so reduced will be reduced pro rata. Within any category of payments and benefits (such as cash payments; accelerated vesting of equity awards other than stock options; accelerated vesting of stock options; and other benefits paid
to the Executive), a reduction shall occur first with respect to amounts that are not “deferred compensation” within the meaning of Section 409A and then with respect to amounts that are “deferred compensation”. 

In the event it is subsequently determined by the Internal Revenue Service that some portion of the Reduced Amount as
determined pursuant to clause (x) in the preceding paragraph is subject to the Excise Tax, Executive agrees to promptly return to the Company a sufficient amount of the Payment so that no portion of the Reduced Amount is subject to the Excise
Tax. For the avoidance of doubt, if the Reduced Amount is determined pursuant to clause (y) in the preceding paragraph, Executive will have no obligation to return any portion of the Payment pursuant to the preceding sentence. 

The accounting firm engaged by the Company for general audit purposes as of the day prior to the effective date of the
Change of Control shall perform the foregoing calculations. If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group effecting the Change of Control, the Company shall appoint a
nationally recognized accounting firm to make the determinations required hereunder. The Company shall bear all expenses with respect to the determinations by such accounting firm required to be made hereunder. The accounting firm engaged to make
the determinations hereunder shall provide its calculations, together with detailed supporting documentation, to the Company and the Executive within fifteen (15) calendar days after the date on which the Executive’s right to a Payment is
triggered (if requested at that time by the Company or the Executive) or such other time as requested by the Company or the Executive. If the accounting firm determines that no Excise Tax is payable with respect to a Payment, either before or after
the application of the Reduced Amount, it shall furnish the Company and the Executive with an opinion reasonably acceptable to the Executive that no Excise Tax will be imposed with respect to such Payment. Any good faith determinations of the
accounting firm made hereunder shall be final, binding and conclusive upon the Company and the Executive. 

  
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 5. Definition of Terms. The following terms referred to in this Agreement shall have
the following meanings: 
 “Cause” shall mean either: (i) any act of personal dishonesty
taken by the Executive in connection with her responsibilities as an Executive and intended to result in substantial personal enrichment of the Executive; (ii) the conviction of a felony; (iii) a willful act by the Executive that
constitutes gross misconduct and that is injurious to the Company; or (iv) following delivery to the Executive of a written demand for performance from the Company that describes the basis for the Company’s belief that the Executive has
not substantially performed her duties, continued violations by the Executive of the Executive’s obligations to the Company that are demonstrably willful and deliberate on the Executive’s part. 

“Change of Control” means the completion by the Company of a reorganization, merger or consolidation, in
each case with respect to which persons who were the stockholders of the Company immediately prior to such reorganization, merger or consolidation would not immediately thereafter own more than 50% of, respectively, the capital stock and the
combined voting power entitled to vote generally in the election of directors of the reorganized, merged or consolidated corporation’s then-outstanding voting securities, or of a liquidation or dissolution of the Company or of the sale of all
or substantially all of the assets of the Company. For purposes hereof, such Change of Control shall be deemed to have occurred on the date on which the transaction closes. 

“Good Reason” shall mean any of the following conditions arising without the Executive’s express
written consent: 
 (i) an assignment to the Executive of material duties or a material reduction of the
Executive’s duties, either of which results in a significant diminution in the Executive’s position or responsibilities in effect immediately prior to the closing date of the Change of Control transaction, or the removal of the Executive
from such position and responsibilities; 
 (ii) a material reduction by the Company (or the successor entity
in the Change of Control transaction) in the base compensation of the Executive as in effect immediately prior to such reduction; or 
 (iii) a relocation of the Executive’s principal place of employment to a facility or a location more than 40 miles from the Executive’s then present location. 

“Stock Rights” shall mean all of the Executive’s options, restricted stock, restricted stock units,
performance stock units or rights to acquire vested ownership of shares of Common Stock of the Company under plans, agreements or arrangements that are compensatory in nature, including, without limitation, the Company’s 1999 Stock Plan, the
Company’s 2005 Equity Incentive Plan, the Company’s 2010 Inducement Award Plan and Restricted Stock Purchase Agreements between the Company and the Executive. 

  
 4 

 “Termination Benefits” shall mean (1) all unvested
Stock Rights (as defined above) shall become fully vested as of the effective date of such termination of employment described in Section 3(a), and (2) the Executive shall continue to receive for a period of twelve (12) months
following the effective date of such termination of employment described in Section 3(a) continued payment of the greater of the Executive’s base salary in effect immediately prior to (i) such termination or (ii) the closing date
of the transaction giving rise to a Change of Control. In addition, the Executive shall have the right to continue her health insurance benefits pursuant to the Consolidated Omnibus Budget Reconciliation Act of 1985 (“COBRA”) and
any analogous provisions of applicable state law. Should the Executive so elect, the Company shall pay the Executive’s COBRA group health insurance premiums for the Executive and her eligible dependents for a period of twelve (12) months
following the effective date of such termination of employment described in Section 3(a) (the “COBRA Payment Period”). References to COBRA premiums shall not include any amounts payable by Executive under an Internal Revenue
Code Section 125 health care reimbursement plan. Notwithstanding the foregoing, if the Company determines, in its sole discretion, that the Company cannot provide the COBRA premium benefits without potentially incurring financial costs or
penalties under applicable law (including, without limitation, Section 2716 of the Public Health Service Act), the Company shall in lieu thereof pay Executive a taxable cash amount, which payment shall be made regardless of whether Executive or
Executive’s eligible family members elect health care continuation coverage (the “Health Care Benefit Payment”). The Health Care Benefit Payment shall be paid in monthly installments on the same schedule that the COBRA Premiums
would otherwise have been paid to the insurer. The Health Care Benefit Payment shall be equal to the amount that the Company would have otherwise paid for COBRA insurance premiums (which amount shall be calculated based on the premium for the first
month of coverage), and shall be paid until the expiration of the COBRA Payment Period. 
 6. Successors. 

(a) Company’s Successors. Any successor to the Company (whether direct or indirect and whether by purchase,
merger, consolidation, liquidation or otherwise) to all or substantially all of the Company’s business and/or assets shall assume the obligations under this Agreement and agree expressly to perform the obligations under this Agreement in the
same manner and to the same extent as the Company would be required to perform such obligations in the absence of a succession. For all purposes under this Agreement, the term “Company” shall include any successor to the Company’s
business and/or assets that executes and delivers the assumption agreement described in this Section 6(a) or that becomes bound by the terms of this Agreement by operation of law. 

(b) Executive’s Successors. The terms of this Agreement and all rights of the Executive hereunder shall inure
to the benefit of, and be enforceable by, the Executive’s personal or legal representatives, executors, administrators, successors, heirs, distributees, devisees and legatees. 

7. Notice. 

  
 5 

 (a) General. Notices and all other communications contemplated by
this Agreement shall be in writing and shall be deemed to have been duly given when personally delivered or when mailed by U.S. registered or certified mail, return receipt requested and postage prepaid. In the case of the Executive, mailed notices
shall be addressed to the Executive at her home address most recently communicated to the Company in writing. In the case of the Company, mailed notices shall be addressed to its corporate headquarters, and all notices shall be directed to the
attention of its Secretary. 
 (b) Notice of Termination. Any termination by the Company for Cause or by
the Executive as a result of a voluntary resignation shall be communicated by a notice of termination to the other party hereto given in accordance with Section 7(a) of this Agreement. Such notice shall indicate the specific termination
provision in this Agreement relied upon, shall set forth in reasonable detail the facts and circumstances claimed to provide a basis for termination under the provision so indicated, and shall specify the termination date (which shall be not more
than 30 days after the giving of such notice). 
 8. Miscellaneous Provisions. 

(a) No Duty to Mitigate. Except as set forth in Section 4, the Executive shall not be required to mitigate
the amount of any payment contemplated by this Agreement, nor shall any such payment be reduced by any earnings that the Executive may receive from any other source. 

(b) Amendment; Waiver. No provision of this Agreement shall be amended, modified, waived or discharged unless the
amendment, modification, waiver or discharge is agreed to in writing and signed by the Executive and by an authorized officer of the Company (other than the Executive). No waiver by either party of any breach of, or of compliance with, any condition
or provision of this Agreement by the other party shall be considered a waiver of any other condition or provision or of the same condition or provision at another time. 

(c) Whole Agreement. No agreements, representations or understandings (whether oral or written and whether express
or implied) that are not expressly set forth in this Agreement have been made or entered into by either party with respect to the subject matter hereof. This Agreement represents the entire understanding of the parties hereto with respect to the
subject matter hereof and supersedes all prior arrangements and understandings regarding same, including that certain Change of Control Agreement, dated as of November 7, 2007, the provisions set forth in Section 9 of that certain offer
letter for Executive, dated July 26, 2005, and the Prior Agreement. 
 (d) Choice of Law. The
validity, interpretation, construction and performance of this Agreement shall be governed by the laws of the State of California as applied to agreements entered into among California residents to be performed entirely within California, without
regard to conflict of laws rules. 

  
 6 

 (e) Severability. The invalidity or unenforceability of any provision
or provisions of this Agreement shall not affect the validity or enforceability of any other provision hereof, which shall remain in full force and effect. 
 (f) Counterparts. This Agreement may be executed in counterparts, each of which shall be deemed an original, but all of which together will constitute one and the same instrument. 

  
 7 

 IN WITNESS WHEREOF, each of the parties has executed this Agreement, in the
case of the Company by its duly authorized officer, as of the day and year set forth below. 
  

					
	 COMPANY:
	 	 XENOPORT, INC.

			
		 	 By:
	 	 /s/ Ronald W. Barrett, PhD

		 		 	 Ronald W. Barrett, PhD

		 		 	 Chief Executive Officer

			
	 EXECUTIVE:
	 		 	 GIANNA M. BOSKO

			
		 	 /s/
	 	 Gianna M. Bosko

		 		 	 Gianna M. Bosko

		 		 	 Sr. VP, Chief Administrative Officer, General Counsel & Secretary

 Signature Page to XenoPort, Inc. Amended and Restated Change of Control Agreement

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