Document:

<PAGE>   1
                                                                  EXHIBIT 10.10

                              SEPARATION AGREEMENT

     THIS SEPARATION AGREEMENT (this "Agreement"), is dated as of this 31st day
of December, 1999, by and between AutoNation, Inc., a Delaware corporation
("AutoNation"), and James O. Cole, a Florida resident ("Cole").

                              W I T N E S S E T H :

     WHEREAS, Cole has served AutoNation as Senior Vice President, General
Counsel and Secretary since June 2, 1997.

     WHEREAS, in accordance with this Agreement, Cole's employment as an
executive officer of AutoNation will be terminated by mutual agreement of the
parties.

     WHEREAS, Cole and AutoNation desire to set forth herein certain agreements
between them with respect to Cole's termination as an executive officer and
employee of AutoNation.

     NOW, THEREFORE, in consideration of the mutual promises and the covenants
contained herein and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto agree as
follows:

     1.   RESIGNATION OF EMPLOYMENT. The foregoing recitals are true and correct
and are part of this Agreement. The terms and conditions of this Agreement have
been approved by the Board of Directors of AutoNation, and this Agreement is
enforceable in accordance with its terms against the parties. For purposes of
this Agreement, the termination of Cole's employment by AutoNation shall be
effective (the "Effective Date") on December 31, 1999.

     2.   SEVERANCE COMPENSATION AND BENEFITS. Cole shall receive the following
severance compensation and benefits:

          (a)  So long as Cole is in compliance in all material respects with
the terms of paragraph 7 of this Agreement, as severance compensation,
AutoNation shall continue to pay Cole his current base salary at the rate of
$450,000 per year until June 30, 2001 (the "Severance Period"), payable in
biweekly or such other installments as is in accordance with AutoNation's normal
payroll practices, and subject to all applicable tax withholding requirements
and other deductions. Cole shall have no obligation to mitigate the severance
compensation by seeking other employment, and no amount of any other
compensation earned by Cole in any other capacity during the Severance Period
shall offset or reduce AutoNation's obligation to pay the severance compensation
to him.

          (b)  So long as Cole is in compliance in all material respects with
the terms of paragraph 7 of this Agreement, Cole shall not be entitled to any
bonuses during the Severance Period, except that he shall be eligible to receive
the portion of his bonus for 1999 to the extent it is related to his individual

<PAGE>   2

performance (i.e. 75% of his bonus), but the portion of his bonus related to
AutoNation's performance against its financial and/or business objectives (i.e.,
25% of his bonus) will be adjusted depending on AutoNation's success in meeting
its financial and/or business objectives in 1999. Cole's total bonus eligibility
will be 35% of his 1999 salary of $450,000. This bonus will be paid in the
course of AutoNation's regular payout schedule in the year 2000.

          (c)  Cole shall be eligible for continuation of AutoNation's group
medical and dental coverage as set forth in the Consolidated Omnibus Budget
Reconciliation Act of 1985. As of the Effective Date, Cole will no longer be
eligible to participate in the following associate benefit programs offered by
AutoNation: (i) vacation benefits, (ii) 401(k), (iii) short term or long term
disability benefits, (iv) travel and accident benefits, or life or dependent
life insurance.

          (d)  Cole has been granted options to purchase a total of 348,385
shares of common stock under AutoNation's various Stock Option Plans
(collectively, the "Plans"), 102,097 of which have previously vested, 87,096 of
which will vest between the Effective Date and June 30, 2000 in accordance with
their original vesting schedules (the "vested options"), and the balance of
159,192 will be canceled and not vest or be exercisable, as set forth below,
notwithstanding anything to the contrary in any of the Plans or stock option
agreements entered into by Cole at the time of the grants:

<TABLE>
<CAPTION>

                                                                      AS OF NEXT
                  NUMBER OF                             AS OF         APPLICABLE         AS OF
                   SHARES                             THE DATE         VESTING         EFFECTIVE
                   UNDER-                              HEREOF,        DATE; TOTAL        DATE,
                   LYING             PER SHARE        NUMBER OF        NUMBER OF       NUMBER OF
                   OPTIONS           EXERCISE          OPTIONS         OPTIONS          OPTIONS         EXPIRATION
GRANT DATE         GRANTED           PRICE($)           VESTED         CANCELED         CANCELED           DATE
----------      ------------        ----------        ---------      ------------    -------------      -----------
<S>               <C>                <C>              <C>               <C>             <C>              <C>
06/02/97          160,000            12.75              80,000          120,000           40,000          06/02/07
01/02/98           88,385            12.75              20,097           44,293           44,292          01/02/08
01/06/99          100,000            15.9375             -0-             25,000           75,000          01/06/09

</TABLE>

Notwithstanding Cole's termination of employment as provided hereunder, the
vested options as set forth above shall be eligible to be exercised by Cole for
the duration of their respective original terms (in each case, 10 years from the
date of grant thereof as set forth above), and shall not expire or be terminated
earlier as a result of the termination of Cole's employment with AutoNation
hereunder. During the Severance Period, Cole shall have the same rights with
regard to the vested options that active, then current executive officers as a
class have with respect to their outstanding stock options, including with
respect to any repricing of outstanding options. At all times, the vested
options shall be adjusted appropriately and automatically for any changes in the
securities underlying the vested options, including stock splits, dividends and
other reclassifications of any nature. Cole acknowledges that he has no further
claim or entitlement to be awarded any future additional grant of options under
the Plans or any other stock option plan of AutoNation. Cole also acknowledges
that the 159,192 options being canceled as of the Effective Date shall be

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forfeited. AutoNation agrees that it will not set off its obligations under the
Plans or this Agreement against any obligation which Cole may have under this
Agreement or otherwise to AutoNation, and AutoNation further agrees that it will
not cancel, forfeit or otherwise refuse to allow Cole to duly exercise his stock
options. Upon exercise by Cole of any of the vested stock options and payment in
full for the underlying shares, AutoNation shall deliver certificates for such
shares to Cole within five days to the address which he specifies in the
exercise notice.

          (e)  In the event of Cole's death or incapacity during the Severance
Period, the severance compensation, benefits and the vested stock options
described above shall be paid or provided to, or be exercisable by, as the case
may be, Ada C. Cole, his wife, his estate, personal representative or guardian.

     3.   COOPERATION; RECORDS; CONFIDENTIALITY. During the Severance Period,
Cole agrees to make himself available to AutoNation and its officers for
consultation on a reasonable basis from time to time as to any and all matters
which he worked on while an officer of AutoNation, provided that AutoNation
shall reimburse Cole for his reasonable expenses incurred in providing such
consultation and making himself available, including attorney's fees and costs,
if necessary (e.g., if Cole is required to be deposed as a witness in any
litigation involving AutoNation). AutoNation acknowledges that Cole may engage
in other full-time employment and AutoNation agrees that it will use its best
efforts to attempt to minimize the amount of time which it shall require of him.
Cole agrees that all records, files, documents, books, security/access badge(s),
and other property of AutoNation (including, without limitation, any cellular
telephone, pager and/or laptop computer, etc.) shall remain in AutoNation's
possession and that he shall not remove any of the same from AutoNation's
premises, without the prior consent of AutoNation. The foregoing
notwithstanding, it is agreed that Cole may retain the computer installed in
Cole's home. At all times hereafter, Cole agrees to maintain the confidentiality
of all proprietary, secret, confidential and other non-public information
concerning AutoNation, including without limitation, any management, sales,
promotional or marketing plans, programs, techniques, practices or strategies,
any expansion plans in existing or new markets or for new or expanded products,
services or lines of business, and any financial statements, monthly operating
reports, budgets, projections and other financial information. Neither Cole nor
AutoNation shall publicly disclose the contents of this Agreement, except to the
extent required under applicable law.

     4.   NO RIGHT TO GIVE INTERVIEWS OR WRITE BOOKS, ETC. During the Severance
Period and the one year period thereafter, except as authorized by AutoNation,
Cole shall not give any interviews or speeches primarily concerning AutoNation,
nor shall Cole, directly or indirectly, prepare or assist any person or entity
in the preparation of any books, articles, television or motion picture
productions or other creations concerning AutoNation, including, without
limitation, any material concerning any person, whether or not fictional, whom
any member of the public might associate with AutoNation (regardless of whether
or not there shall appear any disclaimer purporting to disassociate such

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fictitious person from AutoNation). Notwithstanding the foregoing, Cole may
publicly state factual information about his employment with AutoNation in
providing others with background and resume information about himself, in public
filings with the SEC when required with respect to other issuers for which such
disclosure about him is required, and in similar contexts. During the Severance
Period and thereafter, Cole agrees that he shall not, in any communications with
any third party, criticize, ridicule or make any statement which disparages or
is derogatory of AutoNation or any of AutoNation's affiliates or any of its or
their officers, directors, agents or employees, and AutoNation agrees that it
shall not, in any communications with any third party, criticize, ridicule or
make any statement which disparages or is derogatory of Cole.

     5.   FULL SATISFACTION AND RELEASES. The parties agree that, except as
otherwise provided in this Agreement, this Agreement severs all relationships
between them and shall act as a mutual release of all claims of any nature which
each party may have against the other party as of the Effective Date, except
that the following claims shall not be released hereby: (i) claims by either
party against the other under or pursuant to this Agreement, (ii) claims by Cole
under applicable law in respect of statutory employment benefit rights (such as
COBRA or ERISA claims), and (iii) claims or rights of Cole under law or
AutoNation's certificate of incorporation and bylaws to indemnification against
third party claims arising with respect to his service as an officer and/or
director of AutoNation or any of its subsidiaries, affiliates and related
companies prior to the Effective Date. AutoNation agrees to maintain its
existing or substantially comparable directors and officers insurance coverage
in place for at least five years following the Effective Date, to the extent the
premiums therefor are not more than 200% of the cost of existing premiums, and
agrees to keep the same or broader indemnification rights in place under its
bylaws for at least five years following the Effective Date, to the extent
allowed by applicable law.

     6.   SEC FILING. Cole shall timely file a Form 4 with the Securities and
Exchange Commission reporting that he is no longer an executive officer of
AutoNation as of the Effective Date. After the Effective Date, AutoNation shall
cease to refer to or include Cole as an executive officer in any of its SEC
filings or press releases.

     7.   NON-COMPETE AND NON-SOLICITATION. Cole agrees that for a period of one
(1) year immediately following the Effective Date, except with the prior written
consent of AutoNation, Cole shall not directly or indirectly (whether
individually or as a partner, joint venturer, officer, director, employee,
consultant, agent, independent contractor or stockholder of or lender to any
company or business entity or otherwise), for any reason:

          (a)  engage in any retail automotive consumer business in any market
     in the United States (collectively, the "Automotive Business"); or

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          (b)  request, advise or induce any material customer or material
     vendor of AutoNation, its subsidiaries and related companies (collectively,
     the "AutoNation Group") to withdraw, curtail or cancel any such customer's
     or vendor's business with the AutoNation Group; or

          (c)(i) solicit for employment, or knowingly permit any company or
     business directly or indirectly controlled by him to solicit for
     employment, any person who is employed in Fort Lauderdale, Florida by the
     AutoNation Group at that time, or in any manner seek to induce any such
     person to leave his or her employment with the AutoNation Group, or (ii)
     employ, or permit any company or business directly or indirectly controlled
     by him to employ, any person who is employed in Fort Lauderdale, Florida by
     the AutoNation Group at that time or who was so employed within one year
     prior to that time, provided, however, that Cole, or any company or
     business directly or indirectly controlled by him, may employ any person at
     any time after such person has been terminated (with or without cause) by
     AutoNation. For purposes hereof, "controlled by or affiliated with" shall
     mean any company or business, for which and so long as Cole both (i)
     beneficially owns more than 50% of the outstanding equity, including for
     purposes of such calculation the underlying shares of all options,
     warrants, convertible securities and other rights to purchase securities
     held by Cole, AND (ii) is a general partner, director or executive officer.
     Cole agrees to have written policies in place at companies or businesses
     that are controlled by him that such companies or businesses are not to
     solicit or employ persons in contravention of this paragraph 7(c). In the
     event Cole or a company or business controlled by him hires a current or
     former employee of AutoNation in violation of this paragraph 7(c),
     AutoNation shall provide prompt written notice to Cole, and if such
     employee is not terminated by the company or business controlled by Cole
     within thirty (30) days following the date of such notice, then AutoNation
     shall have the right to seek injunctive and other relief, but shall not
     have the right to cause forfeiture of any of Cole's vested options
     hereunder or to cease payment of severance compensation hereunder.

     Notwithstanding the foregoing, (i) Cole's beneficial ownership of less than
five percent (5%) of the outstanding shares of stock of any corporation having a
class of equity securities actively traded on a national securities exchange or
over-the-counter market, including for purposes of such calculation the
underlying shares of all options, warrants, convertible securities and other
rights to purchase securities held by Cole, shall not be deemed, in and of
itself, to violate the prohibitions of paragraph 7(a), and (ii) if any business
or company (on a consolidated basis with all of its majority-owned subsidiaries)
derives less than five percent (5%) of its annual revenue from the Automotive
Business as defined above, such business or company shall not be deemed for
purposes of paragraph 7(a) to be engaged in the Automotive Business. Also,
Cole's representation as a lawyer of any entity or person engaged in the
Automotive Business shall not be deemed a violation of paragraph 7(a).

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     8.   MISCELLANEOUS.

          (a)  ENTIRE AGREEMENT. This Agreement constitutes the entire agreement
between the parties hereto with respect to the subject matter hereof. It
supersedes all prior negotiations, letters, agreements and understandings
relating to the subject matter hereof.

          (b)  CHOICE OF LAW. This Agreement will be interpreted, construed and
enforced in accordance with the laws of the State of Florida.

          (c)  EFFECT OF WAIVER. The failure of any party at any time or times
to require performance of any provision of this Agreement will in no manner
affect the right to enforce the same. The waiver by any party of any breach of
any provision of this Agreement will not be construed to be a waiver by any such
party of any succeeding breach of that provision or a waiver by such party of
any breach of any other provision.

          (d)  SEVERABILITY. The invalidity, illegality or unenforceability of
any provision or provisions of this Agreement will not affect any other
provision of this Agreement, which will remain in full force and effect, nor
will the invalidity, illegality or unenforceability of a portion of any
provision of this Agreement affect the balance of such provision. In the event
that any one or more of the provisions contained in this Agreement or any
portion thereof shall for any reason be held to be invalid, illegal or
unenforceable in any respect, this Agreement shall be reformed, construed and
enforced as if such invalid, illegal or unenforceable provision had never been
contained herein.

          (e)  EXCLUSIVE VENUE AND JURISDICTION. In the event of a claimed
breach by either party, the non-breaching party may seek injunctive or other
relief from a court of law, but AutoNation shall not have the right to cause
forfeiture of the vested options or to cease payment of severance compensation,
except in accordance with a judgment entered by a court of competent
jurisdiction. Any suit, action or proceeding with respect to this Agreement
shall be brought in the courts of Broward County in the State of Florida or in
the U.S. District Court for the Southern District of Florida. The parties hereto
hereby accept the exclusive jurisdiction of those courts for the purpose of any
such suit, action or proceeding.

          (f)  BINDING NATURE. This Agreement will be binding upon the parties
and will inure to the benefit of any successor or successors of AutoNation. This
Agreement is not assignable by Cole.

          (g)  COUNTERPARTS. This Agreement may be executed in one or more
counterparts, each of which will be deemed an original and all of which together
will constitute one and the same instrument.

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          (h)  NOTICES. All notices which either party shall be required or
permitted to make or give under this Agreement shall be in writing and shall be
sufficiently made or given if sent by personally delivery, by certified mail,
return receipt requested or by nationally recognized overnight courier service,
addressed as set forth below, unless a notice of a change of address has been
previously given in accordance with the foregoing:

         If to Cole:           James O. Cole
                               10 Nurmi Drive
                               Fort Lauderdale, FL 33301

         If to AutoNation:     AutoNation, Inc.
                               110 S.E. 6th Street
                               Fort Lauderdale, FL 33301
                               Attn: Chief Executive Officer

          (i)  PRESS RELEASE. Cole and AutoNation shall mutually agree on the
text of any press release to be issued regarding the termination of Cole's
employment but Cole acknowledges that AutoNation shall have final control over
the time of any press release and comment. All subsequent press releases and
public comment shall be consistent with the mutually agreed upon language of the
initial press release.

          (j)  ARM'S LENGTH NEGOTIATIONS. Each party herein expressly represents
and warrants to the other that (a) before executing this Agreement, said party
has fully informed itself of the terms, contents, conditions and effects of this
Agreement; (b) said party has relied solely and completely upon its own judgment
in executing this Agreement; (c) said party has had the opportunity to seek and
has obtained the advice of its own counsel before executing this Agreement; (d)
said party has acted voluntarily and of its own free will in executing this
Agreement; (e) said party is not acting under duress, whether economic or
physical, in executing this Agreement; and (f) this Agreement is the result of
arm's length negotiations conducted by and among the parties and their
respective counsel.

                            [signatures on next page]

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     IN WITNESS WHEREOF, the parties hereto have executed this Agreement on the
date first written above.

                                AUTONATION, INC.

                                By: /s/ MICHAEL J. JACKSON
                                   ----------------------------------------
                                       Michael J. Jackson,
                                       Chief Executive Officer

                                  /s/ JAMES O. COLE
                                  ------------------------------------------
                                  JAMES O. COLE

                                       8<PAGE>   1

                                                                    EXHIBIT 10.3

                    AMENDED AND RESTATED EMPLOYMENT AGREEMENT
                  BETWEEN CYTRX CORPORATION AND JACK J. LUCHESE

<PAGE>   2

                              AMENDED AND RESTATED
                              EMPLOYMENT AGREEMENT

                                     BETWEEN

                                CYTRX CORPORATION

                                       AND

                                 JACK J. LUCHESE

         This Amended and Restated Employment Agreement ("Agreement") is made
and executed this 1st day of September, 1999 (the "Effective Date"), by and
between CYTRX CORPORATION ("CytRx" or the "Company"), a Delaware Corporation
having its principal place of business at 154 Technology Parkway, Technology
Park/Atlanta, Norcross, Georgia 30092, and JACK J. LUCHESE ("Mr. Luchese") who
currently resides at 3915 River Hollow Run, Duluth, Georgia 30096.

         WHEREAS, CytRx originally employed Mr. Luchese as its President and
Chief Executive Officer pursuant to an Employment Agreement dated March 13,
1989. After several amendments, the original Employment Agreement was amended
and restated effective as of January 1, 1995. That amended and restated
agreement was subsequently amended by Amendment No. 1 dated April 16, 1997,
Amendment No. 2 dated August 28, 1997, and Amendment No. 3 dated April 8, 1998
(collectively, the "1995 Agreement").

         WHEREAS, the Compensation Committee of the Board of Directors of the
Company at its meeting on September 1, 1999, approved certain changes to the
terms of the employment of Mr. Luchese with the Company.

         WHEREAS, as a result of the foregoing, both the Company and Mr. Luchese
concluded that the 1995 Agreement should be amended and restated so as to
incorporate all prior amendments and reflect the most recent amendments.

         WHEREAS, this Agreement amends and restates the 1995 Employment
Agreement.

         WHEREAS, the Board has authorized the execution of this Agreement.

         NOW, THEREFORE, in consideration of the mutual covenants and promises
made in this Agreement, the parties do hereby agree as follows:

1.       EMPLOYMENT. CytRx agrees to and does hereby engage and employ Mr.
Luchese as President and Chief Executive Officer of CytRx Corporation for the
term and upon the

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terms and conditions set forth herein, and Mr. Luchese accepts such offer of
employment. It is also understood and agreed that Mr. Luchese will serve as a
director of the Company, without additional compensation, for any term he is
elected to serve. During the term of this Agreement, the Board of Directors will
take such actions as may be required to nominate and recommend Mr. Luchese for
election as a director by the shareholders. Mr. Luchese agrees to discharge his
duties hereunder in accordance with the direction of the Board of Directors of
CytRx and to follow diligently and implement faithfully all management policies
and decisions communicated to him by the Board of Directors. During the
employment of Mr. Luchese by CytRx, Mr. Luchese shall devote his full and
undivided time, attention, energies and loyalty to the Company's business but
the foregoing shall not be construed to prevent Mr. Luchese from making
investments in other businesses or enterprises or engaging in any other business
activity that does not interfere with Mr. Luchese's duties under this Agreement,
or conflict with his obligations under Paragraph 10 hereof or otherwise
represent a conflict of interest with his duties to CytRx. Notwithstanding the
above, Mr. Luchese may serve on the Board of Directors of companies not
affiliated with CytRx, and receive compensation in connection therewith, if such
position is approved by the Board of Directors of CytRx.

2.       TERM AND RENEWAL. The term of Mr. Luchese's employment hereunder will
be for a period commencing on the Effective Date and continuing until December
31, 2002 (the "Expiration Date"), unless Mr. Luchese's employment is terminated
by either party pursuant to Paragraph 7 of this Agreement.

3.       SALARY.

         (a)      For services provided hereunder, Mr. Luchese will be paid an
annual base salary. Mr. Luchese's base salary as of the Effective Date is Three
Hundred Fifty Thousand Dollars ($350,000). The base salary shall be reviewed by
the Board of Directors of the Company no less than once each 18 months. The base
salary will be increased from time to time consistent with the average overall
merit increases, if any, granted to all employees as a whole for such year, but
will not be decreased. If the base salary is increased, then the increased
amount shall be deemed the "base salary" for all purposes under this Agreement.

         (b)      It is understood and contemplated that, in addition to the
foregoing annual base salary, Mr. Luchese will be eligible to receive cash
bonuses in each calendar year during the term of this Agreement in such amounts,
if any, as shall be determined from time to time by the Board of Directors of
the Company in its sole discretion. The bonus for each year shall accrue, and
become due and payable, on January 1 of the following year, or any later time
requested by Mr. Luchese. If this Agreement expires on the Expiration Date, then
the obligation of the Company to pay a bonus to Mr. Luchese on January 1, 2003,
shall survive such expiration, and the Company shall pay such bonus to Mr.
Luchese as if this Agreement remained in full force and effect.

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<PAGE>   4

4.       FRINGE BENEFITS. Mr. Luchese, during the period of his employment
hereunder, will receive fringe benefits such as insurance, vacation leave, sick
leave and participation in any retirement plan as may exist from time to time
for all other executive officers of the Company; provided, however, that, during
the term of this Agreement, the Company shall maintain at its expense a
long-term disability policy for the benefit of Mr. Luchese, which will provide
coverage equal to a percentage of Mr. Luchese's base salary consistent with the
percentage coverage provided to the other executive officers of the Company.
Such insurance shall include any group long-term disability insurance on Mr.
Luchese that the Company maintains for the benefit of its senior executives. Mr.
Luchese will not receive an automobile or automobile expense allowance. Mr.
Luchese shall be entitled to six weeks of vacation leave, annually, which shall
be paid at his base salary, and shall accrue and be used in accordance with the
policies and procedures of the Company.

5.       REIMBURSEMENT OF BUSINESS EXPENSES. The Company will promptly reimburse
Mr. Luchese for all business expenses incurred by him in connection with the
business of the Company in accordance with regular Company policy regarding the
nature and amount of expenses and the maintenance and submission of receipts and
records necessary for the Company to document them as proper business expenses.

6.       THE EXECUTIVE WARRANTS.

         (a)      Current Status. Exhibit A hereto contains a list of all of the
warrants to acquire CytRx common stock ("Executive Warrants") held by Mr.
Luchese as of September 1, 1999, including with respect to each such warrant:
the grant date, the expiration date, the number of shares, the exercise price
and the vesting status or schedule.

         (b)      Other Registration, Vesting and Exercise Rights.

                  (1)      In addition to any other registration rights Mr.
Luchese may have, the Company has filed or shall file with the Securities and
Exchange Commission a registration statement to register the shares of CytRx
common stock to be acquired under Executive Warrants under the Securities Act of
1933, and shall use its best efforts to keep such registration statement
effective and current for as long as Mr. Luchese has the right to exercise the
Executive Warrants and for a period of six (6) months thereafter, if such
additional period is required to allow Mr. Luchese to dispose of the acquired
shares in an orderly fashion.

                  (2)      All rights to purchase CytRx stock pursuant to the
Executive Warrants that have vested prior to or upon the termination of Mr.
Luchese's employment with the Company may be exercised by Mr. Luchese at any
time until the expiration of such rights under the applicable warrant agreement,
even after Mr. Luchese's employment with the Company has been terminated. All
rights to purchase CytRx stock pursuant to the Executive Warrants that by their
terms vest after the termination of Mr. Luchese's

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<PAGE>   5

employment with the Company shall terminate on the effective date of the
termination of Mr. Luchese's employment.

                  (3)      For all purposes of this Agreement and the Executive
Warrants, (A) in the event of the death of Mr. Luchese, the Executive Warrants
may be exercised by his personal representative, executor, or heirs (whether by
will or by the laws of descent and distribution), and (B) in the event of the
incapacity of Mr. Luchese, the Executive Warrants may be exercised by his duly
appointed attorney-in-fact or other authorized person, in each case, to the same
extent such warrants have vested and are exercisable by the Holder (as defined
in the Executive Warrants) in accordance with the terms thereof.

7.       TERMINATION OF EMPLOYMENT AND THIS AGREEMENT.

         (a)      If Mr. Luchese's employment is terminated by the Company for
cause (as hereinafter defined) or if Mr. Luchese voluntarily leaves the
employment of the Company prior to the Expiration Date, the Company will pay Mr.
Luchese the equivalent of three (3) months' salary at the base salary, and three
(3) months continuation of fringe benefits then being received by Mr. Luchese.
For purposes of this Agreement, termination "for cause" means termination of Mr.
Luchese's employment by action of a majority of the members of the Board of
Directors who are not employees of CytRx or any subsidiary, because of:

                  (1)      material breach of contract,

                  (2)      failure or inability to carry out reasonable
         directives of the Board of Directors,

                  (3)      conviction of Mr. Luchese for a felony, even if such
         conviction is subject to appeal,

                  (4)      uncontroverted evidence of falsification of records
         or statements of the Company,

                  (5)      uncontroverted evidence of intentional misuse of
         Company funds or property, or

                  (6)      other substantial misconduct which, in the reasonable
         judgment of the Board, results in material adverse effect, discredit or
         disrepute to the Company.

         A termination of employment for any cause listed in clauses (1), (2) or
(6) above shall be effective only if Mr. Luchese has first been given notice by
the Board of Directors of the alleged breach, failure to perform or misconduct
and such breach, failure to perform or misconduct continues for fifteen days
following the date of such notice.

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         (b)      If this Agreement expires on the Expiration Date, or if the
sooner termination of Mr. Luchese's employment and this Agreement is not for
cause, not because of Mr. Luchese's death or disability and not because of his
voluntary termination of employment, then the Company will continue to make
semi-monthly base salary payments for a period of one year after the Expiration
Date or the earlier effective date of termination; provided, however, that (1)
in the case of the expiration of this Agreement on the Expiration Date, the
one-year salary continuation period shall be reduced by the period of time
before the Expiration Date that the Board of Directors gives Mr. Luchese written
notice that it intends to allow the Agreement to expire, or not to pay the full
salary continuation obligation if negotiations to renew the Agreement are
unsuccessful, and (2) in all cases, Mr. Luchese's rights to receive salary
continuation payments are contingent upon his using his best efforts to find a
new job commensurate with his position as the chief executive officer and member
of the Board of Directors of the Company. If Mr. Luchese obtains a position
during the one-year salary continuation period (whether commensurate with his
position with the Company or not) the obligation for salary continuation
hereunder shall be limited to an amount equivalent to the difference, if any,
between the base salary under this Agreement and the base salary paid to him by
his new employer. Fringe benefits provided during employment shall be continued
until Mr. Luchese finds another job as provided for under this Subparagraph or
until the end of the one-year salary continuation period, whichever first
occurs.

         (c)      If Mr. Luchese's employment and thereby this Agreement is
terminated because of Mr. Luchese's death, CytRx shall pay any compensation then
due him under this Agreement as of the date of his death to his surviving
spouse, or if there is no surviving spouse, to his estate, and shall make to
such spouse or his estate, as above, semi-monthly payments of salary based on
the annual rate which then would have been applicable to Mr. Luchese's
employment for six (6) months after his death, and provide six (6) months'
continuation of fringe benefits available to his dependents covered for such
benefits at the time of Mr. Luchese's death. If Mr. Luchese becomes permanently
disabled or subject to long term disability during the period of his employment
hereunder, and CytRx terminates this Agreement other than pursuant to Paragraph
7(a), Mr. Luchese's employment shall be deemed to have been terminated without
cause pursuant to Paragraph 7(b); provided, however, that (1) Mr. Luchese shall
not be required to find a new job, and (2) instead of the one-year salary
continuation, an amount equal to his base salary for one year shall be paid to
Mr. Luchese in variable monthly installments until such amount is exhausted,
with each installment being equal to the amount that when combined with payments
received during such month by Mr. Luchese from the Company under its short-term
disability policy, or from one or more insurance companies under long term
disability insurance policies maintained by the Company pursuant to Paragraph 4,
equals the amount of base salary (calculated on a pre-tax basis) that Mr.
Luchese would have received during such month if this Agreement had not been
terminated. For example, if (1) CytRx terminates this Agreement because Mr.
Luchese becomes permanently disabled at a time when his annual base salary is
$350,000, (2) Mr. Luchese

                                       5
<PAGE>   7

is eligible immediately to receive monthly short term disability payments from
the Company equal to $29,167 (100% of his base salary) and (3) Mr. Luchese will
be eligible after one month to receive long term disability payments from the
insurance carrier equal to $17,500 (60% of his base salary), then CytRx will not
be obligated to make any payment to Mr. Luchese for the first month and will be
obligated to pay Mr. Luchese $11,667 per month (40% of his base salary) for the
next 2.5 years (30 months). If, in the above example, Mr. Luchese ceased for any
reason to qualify for the insurance company payments after the first 11 months,
then the Company shall be obligated to make monthly payments of $29,167 (100% of
his base salary) for the following 8 months ($350,000 less the $116,668 already
paid divided by $29,167), subject to the salary adjustment described in
Paragraph 7(b) if Mr. Luchese obtains a position during the 8 month period.

         It is understood that permanently disabled and subject to long term
disability shall mean such sickness, as well as physical or mental disability,
that qualifies or, with the passage of time (not to exceed 90 calendar days),
will qualify Mr. Luchese to receive benefit payments under at least one of the
long-term disability policies maintained by the Company for Mr. Luchese in
accordance with Paragraph 4. In the event of a dispute as to Mr. Luchese's
ability to perform his duties, the Company may refer Mr. Luchese to a licensed
practicing physician of CytRx's choice and reasonably satisfactory to Mr.
Luchese, and Mr. Luchese agrees to submit to such tests and examinations as such
physician shall deem appropriate. The determination by the physician as to
whether or not Mr. Luchese is unable to perform substantially his normal duties
shall conclusively determine such facts for the purposes of this Paragraph 7(c).
Short term illness or injury not amounting to long term disability shall be
treated in accordance with any benefit provided under Paragraph 4 of this
Agreement.

         It is also understood that, if CytRx becomes obligated to make payments
to Mr. Luchese pursuant to this Paragraph 7(c) because of Mr. Luchese's
disability and, within a reasonable period of time after Mr. Luchese's
termination, a majority of the members of the Board of Directors of the Company
who are not employees of CytRx or any subsidiary determine in good faith that
Mr. Luchese should have been terminated for cause in accordance with Paragraph
7(a), then the obligations of the Company under this Paragraph 7(c) shall cease
after the Company has paid to Mr. Luchese an amount equal to the amount due him
pursuant to Paragraph 7(a) and continued Mr. Luchese's fringe benefits for the
period of time required by Paragraph 7(a); provided, however, that in no event
shall Mr. Luchese be required to repay the Company any amounts paid to him under
this Paragraph 7(c).

8.       NO RESTRICTIONS ON MR. LUCHESE'S EMPLOYMENT BY CYTRX. Mr. Luchese
represents as a condition of this Agreement that he is not under any existing
employment agreement, noncompetition agreement or other legally binding
agreement which would prohibit or in any manner restrict his employment
hereunder with CytRx.

                                       6
<PAGE>   8

9.       EMPLOYEE CONFIDENTIALITY AND INVENTION ASSIGNMENT AGREEMENT. Mr.
Luchese and the Company are parties to a confidentiality and invention
assignment letter agreement dated November 3, 1994, which shall be deemed to be
incorporated into this Agreement as if fully set forth in this Paragraph 9.

10.      RESTRICTIONS ON COMPETITION.

         (a)      During Employment. In order to protect CytRx's investment,
which includes but is not limited to, time, money and proprietary information,
and in recognition of the unique character of the Trade Secrets and other
Confidential Information which are the basis of CytRx's business and future
business opportunities, in recognition of the worldwide geographic scope of
CytRx's business and/or potential business opportunities and Mr. Luchese's
contemplated role, responsibilities and knowledge therefor, for the entire
period of Mr. Luchese's employment by CytRx, Mr. Luchese agrees that he will not
work as a consultant for or directly or indirectly perform services anywhere in
the world for himself or any other person, firm or corporation in competition
with CytRx. A business in competition with CytRx includes any business activity
being actively investigated or contemplated by CytRx during the period of Mr.
Luchese's employment by CytRx. Without limitation on the foregoing, but by way
of example, businesses currently contemplated by CytRx as being in competition
with it include pharmaceutical businesses engaged in or considering engaging in
manufacture, marketing or development of commercial products in any and all of
the following areas:

                  (1)      Immune system stimulating compounds and methods;

                  (2)      Growth stimulation of animals;

                  (3)      all formulations and methods using the surface-active
                           copolymers described in U.S. Patent No. 4,801,452,
                           U.S. Patent Application Serial No. 291,925, U.S.
                           Patent Application Serial No. 107,358, U.S. Patent
                           Application Serial No. 208,335, and U.S. Patent
                           Application Serial No. 150,731.

                  (4)      Mycobacterial and antiviral chemotherapy; and

                  (5)      Vaccine adjuvants.

         (b)      For two (2) years after termination of employment. In order to
protect CytRx's investment, which includes but is not limited to, time, money
and proprietary information and in recognition of the unique character of the
Trade Secrets and other Confidential Information which are the basis of CytRx's
business and future business opportunities, in recognition of the worldwide
geographic scope of CytRx's business and/or potential business opportunities and
Mr. Luchese's contemplated role, responsibilities and knowledge therefor, for a
period of two (2) years following the

                                       7
<PAGE>   9

termination of Mr. Luchese's employment with CytRx, regardless of the reason
therefor, Mr. Luchese agrees that he will not work as a consultant for or
directly or indirectly perform services anywhere in the world for himself or any
other person, firm or corporation in any capacity involving the study,
development, use, manufacture or marketing of all formulations and methods using
the surface-active copolymers described in U.S. Patent No. 4,801,452, U.S.
Patent Application Serial No. 291,925, U.S. Patent Application Serial No.
107,358, U.S. Patent Application Serial No. 208,335, and U.S. Patent Application
Serial No. 150,731.

         The foregoing shall not preclude (1) the employment of Mr. Luchese,
whether as a director, officer, employee, consultant or otherwise, by a research
partner, joint venture partner, licensee or other person, or corporation or
entity that at such time is authorized by CytRx to have rights in or to
restricted products, or (2) the ownership by Mr. Luchese of investment
securities representing not more than three (3) per cent of the outstanding
voting securities of company engaged in a pharmaceutical business, whose stock
and/or securities are traded on a national stock exchange or national quotations
system, provided that such investment is passive and not with the intention of
controlling such business.

         (c)      Mr. Luchese will notify the Company at least three (3) weeks
before he is to begin any employment or activity which is described in
Subparagraph (b) of this Paragraph if such employment or activity would commence
within two (2) years after the termination of his employment with CytRx. Such
notice shall be in writing and shall contain a complete description of such
offer, including the position and the responsibilities involved.

         (d)      Mr. Luchese agrees and acknowledges that the restrictions on
competition contained herein including their geographic and product scope are
necessary and reasonable to protect the interests of CytRx and that the
Company's Trade Secrets and other Confidential Information of which he will
become acquainted, if used anywhere in the world during the period in which he
has agreed not to use them or to disclose them would cause CytRx serious and
irreparable damage and harm. Mr. Luchese represents and admits that upon the
termination of his employment with CytRx, his experience and capabilities are
such that he can obtain employment engaged in other lines of endeavor and that
the enforcement of this Agreement would not prevent him from earning a
livelihood.

11.      ACKNOWLEDGMENTS.

         (a)      It is understood and contemplated by the parties that if the
obligations undertaken herein in Paragraphs 9 and 10 were breached in any way,
irreparable harm to the Company should be presumed. Damages might be difficult
if not impossible to ascertain, and the faithful observance of the terms of this
Agreement during and after termination of Mr. Luchese's employment is an
essential condition to his employment with the Company. In light of these
considerations, Mr. Luchese agrees that a court of

                                       8
<PAGE>   10

competent jurisdiction may immediately enjoin any breach or threatened breach of
Paragraphs 9 and 10 to this Agreement, without waiver of any other rights and
remedies which the Company may have at law.

         (b)      The obligations undertaken in Paragraphs 9 and 10 of this
Agreement survive the termination of Mr. Luchese's employment hereunder for the
period specified in each such Paragraph and the termination of this Agreement,
regardless of the reason therefor.

         The obligations of CytRx to Mr. Luchese following his termination of
employment as set forth in Paragraphs 3(b), 6, and 7 shall survive the
termination of this Agreement until satisfied in accordance with the terms
thereof.

         (c)      The rights of Mr. Luchese under this Agreement are in addition
to any other rights or remedies he may have in law or in equity in the event
CytRx breaches this Agreement, all of which rights and remedies are preserved in
full. Without limiting the foregoing, the rights of Mr. Luchese under Paragraph
7 herein do not limit any right he would have upon termination of employment
caused by a breach of CytRx. However, any damages he may sustain shall be
reduced by the payments required to be made under this Agreement.

12.      CONSTRUCTION OF AGREEMENT.

         (a)      It is the intention of the parties to this Agreement that any
construction of this Agreement or Paragraph thereof shall be in favor of its
legality and enforceability and that any construction causing illegality or
unenforceability should yield to a construction favoring legality and
enforceability. Further, the parties agree that should any portion of this
Agreement be judicially held invalid, unenforceable or void, such holding shall
not have the effect of invalidating or voiding any remaining portion of this
Agreement not so declared and that any portion held to be invalid, unenforceable
or void shall, if possible, be deemed amended or reduced in scope, otherwise to
be stricken from this Agreement, but only to the extent required for purposes of
maintaining the legality, validity and enforceability of this Agreement and all
portions thereof in the jurisdiction so holding.

         (b)      It is understood that use of the word "and" herein included
the disjunctive as well as its injunctive meaning whenever such meaning would
broaden the protection to the Company in the context in which it is used.

13.      NO WAIVER. No waiver of any breach of this Agreement may be construed
or deemed as a waiver of any succeeding breach of this Agreement.

14.      PERSONAL SERVICES. It is understood and contemplated that this
Agreement provides for personal services of Mr. Luchese to the Company.

                                       9
<PAGE>   11

15.      NO INTERFERENCE. For two (2) years following the termination of Mr.
Luchese's employment hereunder, regardless of the reason therefor, Mr. Luchese
will not intentionally disrupt or attempt to disrupt the Company's business
relationship with its customers or suppliers, nor solicit any of the Company's
employees to terminate their employment with CytRx.

16.      CERTIFICATION BY EMPLOYEE. Mr. Luchese certifies that he has received a
copy of this Agreement for review and study before being asked to execute it,
that he has read this Agreement carefully, that he has had a sufficient
opportunity before executing this Agreement to ask questions about it and to
receive answers to any such questions and that he understands the obligations
and rights provided hereunder.

17.      ENTIRE AGREEMENT. This Agreement hereto supersedes any and all other
agreements, both oral and in writing, between the parties hereto with respect to
the employment and terms and conditions thereof of Mr. Luchese by CytRx, and it
contains all of the parties' representations, covenants and agreements with
respect to such matters. The terms of this Agreement may not be changed orally
but only by a subsequent writing signed by the party against whom enforcement of
such modification is sought.

18.      CAPTIONS. Paragraph captions used herein are for convenience of
reference only and shall not change the meaning of the terms of this Agreement.

19.      SUCCESSORS AND ASSIGNS. The terms of this Agreement shall inure to the
benefit of any successors and assigns of the Company.

20.      GOVERNING LAW. This Agreement shall be construed and governed in
accordance with the laws of the State of Georgia.

21.      CORPORATE AUTHORITY. The Company represents and warrants that this
Agreement including the issuance of the warrants (1) has been duly authorized,
executed and delivered by the Company, (2) constitutes a legal, valid and
binding obligation of the Company enforceable in accordance with its terms, and
(3) does not conflict with or result in a violation of the Company's Certificate
of Incorporation, By-laws, or any contract, agreement or instrument to which the
Company is a party or is otherwise bound.

                         (signatures on following page)

                                       10
<PAGE>   12

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement
under seal on the date hereof, to be effective as of the Effective Date.

                                  JACK J. LUCHESE:

                                  ----------------------------

Attest:                           CYTRX CORPORATION:

-------------------               ----------------------------
Corporate Secretary               By:    William B. Fleck
(CORPORATE SEAL)                  Title: Vice President, Human Resources

                                  ----------------------------
                                  By:    Herbert H. McDade, Jr.
                                         Chairman, CytRx Compensation Committee

<PAGE>   13

                                                                       EXHIBIT A

                               Executive Warrants

         Mr. Luchese has the following Executive Warrants as of September 1,
1999(1):

<TABLE>
<CAPTION>
WARRANT     GRANT       EXPIRATION      WARRANT       EXERCISE    VESTING
ID NO.      DATE        DATE            SHARES        PRICE       STATUS

<S>         <C>         <C>             <C>           <C>         <C>
WI/II-1     2/20/95(2)  12/31/04        500,000       $ 1.00      100%
WI/II-2     2/20/95(3)  02/22/01         50,000       $ 1.00      100%
WIII-2      2/20/95(4)  03/24/03         32,427       $ 1.00      100%
WIV-2       2/20/95(5)  12/31/04        100,000       $ 1.00      100%
None        3/26/96(6)  03/25/06        200,000       $ 1.00      See schedule
                                                                  (A) below
None        6/6/97(7)   06/05/07         50,000       $ 1.00      See schedule
                                                                  (B) below
None        4/8/98(8)   04/07/08        450,000       $ 1.00      100%
None        9/1/99      08/31/09        500,000       $2.125      See schedule
                                                                  (C) below
</TABLE>

-----------------------
(1) The Warrant numbers and prices have been adjusted to reflect the reverse
stock split occurring on February 5, 1996.

(2) First amended by Amendment No. 1 on April 16, 1997, to provide that it is
fully vested. Last amended by Amendment No. 2 on September 15, 1998, to reduce
the exercise price from $4.50 to $1.00.

(3) First amended by Amendment No. 1 on April 16, 1997, to provide that it is
fully vested. Last amended by Amendment No. 2 on September 15, 1998, to reduce
the exercise price from $4.50 to $1.00.

(4) First amended by Amendment No. 1 on April 16, 1997, to provide that it is
fully vested. Last amended by Amendment No. 2 on September 15, 1998, to reduce
the exercise price from $7.00 to $1.00.

(5) First amended by Amendment No. 1 on April 16, 1997, to amend vesting
schedule. Now fully vested. Last amended by Amendment No. 2 on September 15,
1998, to reduce the exercise price from $7.00 to $1.00.

(6) First amended by Amendment No. 1 on April 16, 1997 to provide for full
vesting upon a Change in Control, as defined. Later amended by Amendment No. 2
on April 8, 1998 to change the vesting schedule by changing the price target
from $15 to $7.50. Last amended by Amendment No. 2 on September 15, 1998, to
reduce the exercise price from $4.50 to $1.00.

(7) First amended by Amendment No. 1 on April 8, 1998, to change the vesting
schedule by changing the price target from $20 to $12. Last amended by Amendment
No. 2 on September 15, 1998, to reduce the exercise price from $4.125 to $1.00.

(8) Amended by Amendment No. 1 on September 15, 1998, to reduce the exercise
price from $2.9375 to $1.00, and to reduce the vesting target stock prices from
$5 to $1.50, $7.50 to $2.00, and $10 to $2.50, respectively.

<PAGE>   14

SCHEDULE (A) - VESTING SCHEDULE FOR 1996 WARRANTS

         25,000 on sale/IPO of Vaxcel by December 31, 1998 EXPIRED

         25,000 on sale/IPO of VetLife by December 31, 1998 VESTED

         25,000 on sale/IPO of Proceutics by December 31, 1998 VESTED

         25,000 on third-party funding of RheothRx by December 31, 1998 EXPIRED

         50,000 on significant business transaction by December 31, 1998 EXPIRED

         50,000 on market price sustaining $7.50 by December 31, 1998 EXPIRED

         OR 100% on a Change in Control, as defined.

SCHEDULE (B) - VESTING SCHEDULE FOR 1997 WARRANTS

         6,250 on each of March 31, 1999; June 30, 1999; September 30, 1999 and
         December 31, 1999 or earlier on death, disability or termination of
         employment without cause before 12/31/99 or upon a Change in Control.

         25,000 if on or before December 31, 1999 the stock price averages $12
         for 10 days or there is a Change in Control.

SCHEDULE (C) - VESTING SCHEDULE FOR 1999 WARRANTS

         25,000 on each of March 31, 2000, June 30, 2000, September 30, 2000;
December 31, 2000, March 31, 2001, June 30, 2001, September 30, 2001; December
31, 2001, March 31, 2002, June 30, 2002, September 30, 2002; and December 31,
2002, or as to all 300,000 shares upon a Change of Control on or before December
31, 2002.

         50,000 if the stock price reaches $5.00 on or before July 1, 2000 or
upon a Change of Control on or before July 1, 2000.

         75,000 on (i) the successful completion of a significant merger,
acquisition or strategic alliance on or before December 31, 2002, (ii)
successfully raising a total of $15,000,000 on or before December 31, 2000, or
(iii) a Change of Control on or before December 31, 2002.

         75,000 on (i) the successful NDA/PLA regulatory (FDA) approval of
FLOCOR on or before December 31, 2002, or (ii) a Change of Control on or before
December 31, 2002.

                                      -2-

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