Document:

Exhibit
4.4

    

    ZIOPHARM
Oncology, Inc.

    

    Amendment
No. 3 to

    2003
Stock Option Plan

    

    This Amendment No. 3 to 2003 Stock
Option Plan (the “Amendment”) dated as of June
4, 2009, amends the 2003 Stock Option Plan (the “2003 Plan”) of ZIOPHARM Oncology,
Inc. (the “Company”).  Except
as otherwise explicitly set forth herein, all provisions of the 2003 Plan shall
remain in full force and effect.  Capitalized terms used in this
Amendment without definition shall have the meanings set forth in the 2003
Plan.

    

    WHEREAS, the 2003 Plan
provides that the number of shares of Common Stock which may be issued under the
Plan shall not exceed 4,002,436 shares; and

    

    WHEREAS,  an
amendment to the 2003 Plan increasing the number of shares of Common Stock which
may be issued under the Plan to 6,002,436 was adopted by the Company pursuant to
resolutions of the Board of Directors on December 3, 2008 and approved by the
Company’s stockholders at a meeting of the stockholders held on June 4,
2009.

    

    NOW, THEREFORE, the 2003 Plan
is hereby amended as follows:

    

    1.           Increase in Number of Shares Subject
to the Plan.  Section 5.1 of the 2003 Plan is hereby amended in
its entirety to read as follows:

    

    “5.1.     Number of Shares.
Subject to adjustment as provided in Section 10.6, the number of shares of
Common Stock which may be issued under the Plan shall not exceed 6,002,436
shares of Common Stock.  Shares of Common Stock that are issued under
the Plan or are subject to outstanding Incentives will be applied to reduce the
maximum number of shares of Common Stock remaining available for issuance under
the Plan.”

     

    2.           Effective Date. This Amendment
shall be effective upon the date first written above.

    

    IN WITNESS WHEREOF, the
Company has caused this Amendment to be executed by the undersigned officer,
thereunto duly authorized pursuant to the resolutions of the Board of
Directors.

    

    
      
        
          
            
              	
                      ZIOPHARM
      Oncology, Inc.:

                    
	 
      	 
      
	
                      By:

                    	
                      /s/
      Richard E. Bagley

                    
	
                       

                    	      
                      Richard
      E. Bagley, President,
      Chief

                      Operating
      Officer and
TreasurerASSIGNMENT  AGREEMENT

    

    This
Agreement is made effective (the “Effective Date”) as of the 24th day of June,
2009.

    

    BETWEEN:

     

    QELE
RESOURCES, INC. (changing its name to Brand Neue Corp or such other name
approved by its directors), with its address for notices at 105 SE
Executive Drive, Suite 13, Bentonville, Arkansas,
USA   72712

    

    (the
“Assignee”)

    

    AND:

    

    WORLD
SOURCING & SUPPLIER DEVELOPMENT INC., a company established under
the laws of Arkansas, and having its address for notices hereof at 105 SE
Executive Drive, Suite 13, Bentonville, Arkansas,
USA   72712

    

    (the
“Assignor”)

    

    (the
Assignor and the Assignee being hereinafter singularly also referred to as a
“Party” and
collectively referred to as the “Parties” as the context so
requires).

    

    WHEREAS:

    

    
      	
              A.  

            	
              The
      Assignee wishes to acquire all interest in and to a license agreement
      (“License Agreement”) made June 1, 2009 between the Assignor and Gizmo
      Packaging Ltd. of Scotland whereby the Assignor acquired rights to a
      bottle capping device called the “Gas Cap”
;

            

    

    

    NOW
THEREFORE THIS AGREEMENT WITNESSETH that in consideration of
the mutual promises, covenants and agreements herein contained, THE
PARTIES HERETO COVENANT AND AGREE WITH EACH OTHER as
follows:

    

    Article
1

    

    ASSIGNMENT OF THE LICENSE
AGREEMENT

    

    1.1                      Assignment.   The
Assignee hereby purchases and the Assignor hereby sells and transfers 100% of
the Assignor’s right, title and interest in and to the License Agreement, and
the Assignee hereby assumes all obligations thereof, in consideration
of:

    

    
      	
              (a)    

            	
              a
      ten (10%) profit interest of all revenue of the products of the License
      Agreement but that in no event shall such profit interest be less than a
      3% gross sales/revenue royalty.  Revenue shall be calculated
      from all sources including sales, royalties, fees, or any other revenue
      source.  The profit interest shall be calculated from all costs
      of goods, third party costs, warehousing, transport and any other direct
      costs plus an administrative cost of 10%  and no other costs, in
      particular costs of other
businesses;

            

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        -2-

      

    

     

    
      	
              (b)    

            	
              in
      the event that the Assignee shall grant licenses or assign rights to the
      product of the License Agreement or to the License Agreement or assign the
      entire License Agreement then the Assignor shall receive 50% of the
      consideration for such assignment;

            

    

    
      	
              (c)    

            	
              payment
      of disbursements by the Assignor or its principals in respect to the
      License Agreement, such payments estimated at approximately
      $400,000US.  Such disbursements shall be supported by
      documentary proof and shall be paid on or before December 31,
      2009

            

    

    

    1.2                      License
Agreement Title.   The Assignor warrants and represents
that the License Agreement is owned 100% by the Assignor, that it has not
encumbered or transferred any interest in the same and that the License
Agreement is in good standing and that all payments required thereunder to date
have been paid.

    

    1.3                      Assignee
Obligations.   The Assignee warrants that all costs,
obligations and any other burden or liability of the License Agreement is
assumed by the Assignee hereby.

    

    Article
2

    

    
      	
              CONFIDENTIAL
      INFORMATION AND ASSIGNEE
QUALIFICATION

            

    

    

    2.1                      Confidential
Information.   No information in respect to this Agreement
or furnished by any Party hereto in respect of the activities carried out in
connection with or related to this Agreement or the License Agreement shall be
published or disclosed to third parties by any Party without the prior written
consent of the other Party, but such consent in respect of the reporting of
factual data shall not be unreasonably withheld, and shall not be withheld in
respect of information required to be publicly disclosed pursuant to applicable
laws or court orders.

    

    Article
3

    

    
      	
              GENERAL
      PROVISIONS

            

    

    

    3.1                      Entire
Agreement.   This Agreement constitutes the entire
agreement between the Parties hereto and supersedes every previous agreement,
communication, expectation, negotiation, representation or understanding,
whether oral or written, express or implied, statutory or otherwise, between the
Parties with respect to the subject matter of this Agreement.

    

    3.2                      Enurement,
Capacity and Assignment.   This Agreement will enure to
the benefit of and will be binding upon the Parties, their respective heirs,
executors, administrators and assigns.  The Parties hereto have full
legal right and capacity to enter into and effect the terms of this Agreement
and have each sought counsel as to their obligations and their capacity, under
prevailing securities law or otherwise, to effect the Agreement hereby
contained.  Neither this Agreement nor any rights hereunder may be
assigned by any Party except with the written permission of the other Party,
which permission may be with held without reason.

    

    3.3                      Notice.   Each
notice, demand or other communication required or permitted to be given under
this Agreement shall be in writing and shall be delivered to the Party or
Parties entitled to receive the same, at the address for such Party or Parties
specified above.  The deemed date of receipt of such notice, demand or
other communication shall be the second business day following the date of
actual delivery thereof if electronically or physically delivered.  If
delivered by mail then the deemed date of delivery shall be the tenth day
following mailing of notice, absent postal disruptions in which event it shall
be the actual date of delivery to the recipient.  Any Party may at any
time and from time to time notify the other Party in writing of a change of
address and the new address to which notice shall be given to it thereafter
until further change.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        -3-

      

    

    
3.4                      Applicable
Law.   This Agreement will be governed exclusively by and
construed and enforced in accordance with the laws prevailing in Arkansas and in
the courts thereof.

    

    3.5                      Further
Assurances.   The Parties hereto hereby, jointly and
severally, covenant and agree to forthwith, upon request, execute and deliver,
or cause to be executed and delivered, such further and other deeds, documents,
assurances and instructions as may be required by the Parties hereto or their
respective counsel in order to carry out the true nature and intent of this
Agreement.

    

    3.6                      Counterparts
and Facsimile.   This Agreement may be signed by the
Parties hereto in as many counterparts as may be necessary, each of which so
signed shall be deemed to be an original, and may be exchanged by facsimile and
such counterparts and facsimiles together shall constitute one and the same
instrument and notwithstanding the date of execution will be deemed to bear the
Effective Date as set forth on the front page of this Agreement.

    

    

    IN
WITNESS WHEREOF the Parties have hereunto set their hands and given their
agreement as of the Effective Date.

    

    

    
      	
              QELE RESOURCES,
      INC.

            	 	
              )

            
	
              by
      its authorized signatory:

            	 	
              )

            
	 
      	 	
              )

            
	   	 	
              )

            
	
              Authorized
      Signatory

            	 	
              )

            
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	 
      	 	 
      
	
              WORLD SOURCING
      &

            	 	
              )

            
	
              SUPPLIER DEVELOPMENT,
      INC.,

            	 	
              )

            
	
              by
      its authorized signatory:

            	 	
              )

            
	 
      	 	
              )

            
	 
      	 	
              )

            
	    
      	 	
              )

            
	
              Authorized
      Signatory

            	 	
              )

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