Document:

EX-4.3

 Exhibit 4.3 

INVESTOR RIGHTS AGREEMENT 

INVESTOR RIGHTS AGREEMENT (the “Agreement”) made and entered into as of February 20, 1998, by and among FIBROGEN, INC., a
Delaware corporation (the “Company”), and the parties who have executed this Agreement as Investors (the “Investors”). 
 THE PARTIES
AGREE AS FOLLOWS: 
 ARTICLE 1 

DEFINITIONS 
 As used in this
Agreement, the following terms shall have the following respective meanings: 
 1.1 “Commission” shall mean the Securities
and Exchange Commission or any other federal agency at the time administering the Securities Act. 
 1.2 “Holder” shall
mean any holder of outstanding Registrable Securities which have not been sold to the public but only if such holder is an Investor or an assignee or transferee of registration rights permitted by Section 2.10. 

1.3 “Piggy-back Registration” shall have the meaning set forth in Section 2.1. 

1.4 “Registration Expenses” shall have the meaning set forth in Section 2.5. 

1.5 “Registrable Securities” shall mean all Common Stock of the Company issued or issuable upon conversion of the
Company’s Series C Preferred Stock, including Common Stock issued pursuant to stock splits, stock dividends and similar distributions with respect to the Registrable Securities, and any securities of the Company granted registration rights
pursuant to Section 3.9 of this Agreement. 

 1.6 “Securities Act” shall mean the Securities Act of 1933, as amended, or any
similar federal statute, and the rules and regulations of the Commissioner thereunder, all as the same shall be in effect at the time. 

ARTICLE 2 
 REGISTRATION RIGHTS

 2.1 Piggy-back Registration. If at any time the Company proposes to file a registration statement under the Securities Act with
respect to an offering of its Common Stock (i) for the Company’s own account (other than a registration statement on Form S-4 or S-8 or any substitute form that may be adopted by the Commission or a registration statement with respect to
the first registered offering of the Company’s Common Stock to the public). or (ii) for the account of any holders of its Common Stock, then the Company shall give written notice of such proposed filing to each Holder as soon as
practicable (but in no event less than ten days before the anticipated filing date), and such notice shall offer each Holder the opportunity to register such number of shares of Registrable Securities as such Holder may request on the same terms and
conditions as the Company’s or such holder’s registration (a “Piggy-back Registration”); provided, that the Holders shall have this right only (i) after the Company’s initial public offering, and (ii) if the
underwriters for the primary offering approve that secondary shares be included. 

  
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 2.2 Underwriting. If the registration of which the Company gives notice is for a
registered public offering involving an underwriting, the Company shall so advise the Holders as a part of the written notice given pursuant to Section 2.1. In such event, the right of any Holder to registration pursuant to this Section 2
shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities
through such underwriting shall (together with the Company and the other holders of securities of the Company with registration rights to participate therein distributing their securities through such underwriting) enter into an underwriting
agreement in customary form with the representative of the underwriter or underwriters selected by the Company. 
 2.3 Reduction of
Offering. Notwithstanding anything contained herein, if the managing underwriter of an offering described in Section 2.2 hereof delivers a written opinion to the Company that the amount of Registrable Securities requested to be included in
such offering by the Holders, the Company and any other persons exceeds the amount of such Registrable Securities which can be successfully sold in such offering, then the amount of Registrable Securities to be offered for the account of each Holder
shall be reduced to the extent necessary to reduce the total amount of securities to be included in such offering to the amount recommended by such managing underwriter; provided, that the proportion by which the amount of such Registrable
Securities 

  
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intended to be offered for the account of each participating Holder is reduced shall not exceed the proportion by which the amount of such securities intended to be offered for the account of
each other Holder or person is reduced. 
 2.4 Plan of Distribution. The Company may require, as a condition precedent to its
registration obligations under this Article 2, that each Holder promptly furnish in writing to the Company such information regarding such Holder, the plan of distribution of the Registrable Securities and other information as the Company may from
time to time reasonably request or as may be legally required in connection with such registration. 
 2.5 Registration Expenses. All
expenses incurred by the Company in connection with the Company’s performance of or compliance with this Article 2, including, without limitation: (i) all registration and filing fees (including for filings with the Commission or the
National Association of Securities Dealers, Inc.), (ii) fees and expenses of compliance with securities or blue sky laws (including reasonable fees and disbursements of counsel in connection with blue sky qualifications of the Registrable
Securities), (iii) printing expenses, (iv) fees and expenses incurred in connection with the listing of the Registrable Securities, and (v) fees and expenses of counsel and independent certified public accountants for the Company (all
such expenses being herein called “Registration Expenses”), shall be paid by the Company except as otherwise expressly provided in this Section 2.5. Each participating Holder shall pay any underwriting fees, discounts or commissions
attributable to the 

  
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sale of Registrable Securities and any out-of-pocket expenses of such Holder. 
 2.6
Indemnification by the Company. The Company hereby agrees to indemnify, to the extent permitted by law, each Holder, its partners, officers and directors, if any, and each person, if any, who controls such Holder within the meaning of the
Securities Act, against all losses, claims, damages, liabilities and expenses (under the Securities Act, applicable state securities laws, common law or otherwise) caused by any untrue statement or alleged untrue statement of a material fact
contained in any registration statement or prospectus (and as amended or supplemented if the Company has furnished any amendments or supplements thereto) or any preliminary prospectus, which registration statement, prospectus or preliminary
prospectus shall be prepared in connection with Piggy-back Registration, or caused by any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, except
insofar as such losses, claims, damages, liabilities or expenses are caused by any untrue statement or alleged untrue statement contained in or by any omission or alleged omission from information furnished in writing to the Company by such Holder
in connection with a Piggy-back Registration, provided the Company will not be liable pursuant to this Section 2.6 if such losses, claims, damages, liabilities or expenses have been caused by (a) any Holder’s failure to deliver a copy
of the registration statement or prospectus, or any amendments or supplements 

  
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thereto, after the Company has furnished such Holder with a sufficient amount of copies of the same or (b) any untrue statement or omission based upon information furnished to the Company by
such Holder or controlling person for use in connection with the offering of securities. 
 2.7 Indemnification by the Holders of
Registrable Securities. In connection with any registration statement in which a Holder is participating, each such Holder shall furnish to the Company in writing such information as is reasonably requested by the Company for use in any such
registration statement or prospectus and shall indemnify, to the extent permitted by law, the Company, its directors and officers and each person, if any, who controls the Company within the meaning of the Securities Act, against any losses, claims,
damages, liabilities and expenses resulting from any untrue statement or alleged untrue statement of a material fact or any omission or alleged omission of a material fact required to be stated in the registration statement or prospectus or any
amendment thereof or supplement thereto or necessary to make the statements therein not misleading, but only to the extent such losses, claims, damages, liabilities or expenses are caused by an untrue statement or alleged untrue statement contained
in or by an omission or alleged omission from information so furnished in writing by such holder in connection with the Piggy-back Registration; provided that no such Holder shall be liable under this Section 2.7 for any amounts exceeding the
product of (i) the offering price per share of Registrable Securities pursuant to 

  
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the registration statement in which such Holder is participating, multiplied by (ii) the number of shares of Registrable Securities being sold by such Holder pursuant to such registration
statement. If the offering pursuant to any such registration is made through underwriters, each such Holder agrees to enter into an underwriting agreement in customary form with such underwriters and to indemnify such underwriters, their officers
and directors, if any, and each person who controls such underwriters within the meaning of the Securities Act to the same extent as hereinabove provided with respect to indemnification by such Holder of the Company. 

2.8 Conduct of Indemnification Proceedings. Promptly after receipt by an indemnified party under Section 2.6 or Section 2.7
of notice of the commencement of any action or proceeding, such indemnified party will, if a claim in respect thereof is made against the indemnifying party under such Section, notify the indemnifying party in writing of the commencement thereof;
but the omission so to notify the indemnifying party will not relieve it from any liability which it may have to any indemnified party otherwise than under such Section. In case any such action or proceeding is brought against any indemnified party,
and it notifies the indemnifying party of the commencement thereof, the indemnifying party will be entitled to participate therein, and, to the extent that it wishes, jointly with any other indemnifying party similarly notified, to assume the
defense thereof, with counsel reasonably satisfactory to such indemnified party, and after notice from the 

  
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indemnifying party to such indemnified party of its election so to assume the defense thereof, the indemnifying, party will not be liable to such indemnified party under such Section for any
legal or any other expenses subsequently incurred by such indemnified party in connection with the defense thereof (other than reasonable costs of investigation) unless incurred at the written request of the indemnifying party. Notwithstanding the
above, the indemnified party will have the right to employ counsel of its own choice in any such action or proceeding if the indemnified party has reasonably concluded that there may be defenses available to it which are different from or additional
to those of the indemnifying party, or counsel to the indemnified party is of the opinion that it would not be desirable for the same counsel to represent both the indemnifying party and the indemnified party because such representation might result
in a conflict of interest (in either of which cases the indemnifying party will not have the right to assume the defense of any such action or proceeding on behalf of the indemnified party or parties and such legal and other expenses will be borne
by the indemnifying party). An indemnifying party will not be liable to any indemnified party for any settlement of any such action or proceeding effected without the consent of such indemnifying party. 

2.9 Contribution. If the indemnification provided for in Section 2.6 or Section 2.7 is unavailable under applicable law to an
indemnified party in respect of any losses, claims, damages or liabilities referred to therein, then each applicable 

  
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indemnifying party, in lieu of indemnifying such indemnified party, shall contribute to the amount paid or payable by such indemnified party as a result of such losses, claims, damages or
liabilities in such proportion as is appropriate to reflect the relative fault. 
 2.10 Transfer of Registration Rights. The
registration rights of any Holder under this Article 2 may be transferred by such Holder to a transferee of its Registrable Securities who agrees in writing to be bound by the provisions of this Agreement (a) if such transferee acquires at
least 20% of such Holder’s Registrable Securities (or, if the transferring Holder acquired registration rights through a transfer pursuant to this Section 2.10, at least 20% of the Registrable Securities held by the original party to this
Agreement), or (b) if such transferee is a partner or stockholder of such Holder, without restriction as to the minimum amount acquired. 

ARTICLE 3 
 MISCELLANEOUS 

3.1 Successors and Assigns. Subject to the exceptions specifically set forth in this Agreement, the terms and conditions of this
Agreement shall inure to the benefit of and be binding upon the respective executors, administrators, heirs, successors and assigns of the parties. 

3.2 Governing Law. Except to the extent that the Delaware General Corporation Law shall be applicable with respect to matters relating
to the internal corporate affairs of the Company, this Agreement and (unless otherwise provided) all 

  
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amendments, supplements, waivers and consents relating thereto or hereto shall be governed by and construed in accordance with the laws of the State of California. 

3.3 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed to be an original, but all
of which together shall constitute one and the same instrument. 
 3.4 Headings. The headings of the Articles and Sections of this
Agreement are for convenience and shall not by themselves determine the interpretation of this Agreement. 
 3.5 Notices. Any notice
required or permitted hereunder shall be given in writing and shall be conclusively deemed effectively given upon personal delivery, or five business days after deposit in the United States mail, by first class mail, postage prepaid, and addressed
(i) if to the Company, as set forth below the Company’s name on the signature page of this Agreement, and (ii) if to an Investor, at such Investor’s address as set forth in the books of the Company, or at such other addresses as
the Company or such Investor may designate by ten days’ advance written notice to the Investor or the Company, respectively. Investors with addresses outside of the United States shall be given such notice by facsimile at such Investor’s
facsimile number as set forth in the books of the Company, or at such other facsimile number as the Investor may designate by ten (10) days’ written notice to the Company. 

3.6 Amendment of Agreement. Any provision of this Agreement may be amended only by a written instrument signed by

  
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the Company and by persons holding at least fifty-one percent of the Registrable Securities then outstanding. 

3.7 Severability. If any provision of this Agreement is held to be unenforceable for any reason, it shall be adjusted rather than
voided, if possible, in order to achieve the intent of the parties to the extent possible. In any event, all other provisions of this Agreement shall be deemed valid and enforceable to the full extent possible. 

3.8 Entire Agreement; Effectiveness of Agreement; Termination of Prior Agreements. This Agreement constitutes the entire contract
between the Company and the Investors relative to the subject matter hereof. This Agreement shall become effective with respect to each Investor upon the execution of this Agreement by such Investor. 

 

	 	3.9	Additional Parties. From and after the date of this Agreement, the Company may grant registration rights under this Agreement to any holder or prospective holder of securities of the Company. Upon execution of a
signature page to this Agreement by any such additional party and by the Company, such additional party shall be considered an Investor for all purposes of this Agreement. 

  
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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year
first above written. 
  

					
	 THE COMPANY:
	 	FIBROGEN, INC.
			
		 	By:	 	 /s/ Thomas B. Neff

		 	Title:	 	 CEO

		 	Address: 225 Gateway Blvd.
		 	South San Francisco , California 94080
		 		 	Attention: President
		
	THE INVESTORS:	 	  

		 	(Print name of Investor)
		
		 	  

		 	(Signature)
		
		 	  

		 	(Name and title of signatory if Investor is not an individual)

  
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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year
first above written. 
  

					
	 THE COMPANY:
	 	FIBROGEN, INC.
			
		 	By:	 	  

		 	Title:	 	  

		 	Address: 225 Gateway Blvd.
		 	South San Francisco , California 94080
		 		 	Attention: President
		
	THE INVESTORS:	 	 Wagner & Brown, Ltd.

		 	(Print name of Investor)
		
		 	 /s/ Adam C. Wagner

		 	(Signature)
		
		 	 Adam c. Wagner

Vice President, Investments

		 	(Name and title of signatory if Investor is not an individual)

  
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 Exhibit 4.4 

INVESTORS’ RIGHTS AGREEMENT 

THIS INVESTORS’ RIGHTS AGREEMENT (the “Agreement”) is made as of the 12th day of May, 2000 by and among FibroGen, Inc., a
Delaware corporation (the “Company”), and the purchasers of the Company’s Series E Preferred Stock (the “Series E Preferred”) listed on the signature pages hereto (the “Investors”). 

RECITALS 
 WHEREAS, the
Investors are parties to the Preferred Stock Purchase Agreement of even date herewith among the Company and the Investors (the “Purchase Agreement”), which provides that as a condition to the closing of the sale of shares of the
Company’s Series E Preferred, this Agreement must be executed and delivered by the Investors and the Company; 
 WHEREAS, the Company
wishes to provide a further inducement to the Investors to purchase the Series E Preferred pursuant to the Purchase Agreement; and 

WHEREAS, the Company desires to grant, and the Investors desire to be granted, the rights created herein. 

NOW, THEREFORE, in consideration of the mutual promises and covenants set forth herein, the parties hereto agree as follows: 

1. Registration Rights. The Company covenants and agrees as follows: 

1.1 Definitions. For purposes of this Section 1: 

(a) The term “Act” means the Securities Act of 1933, as amended. 

(b) The term “Form S-3” means such form under the Act as in effect on the date hereof or any registration form under the Act
subsequently adopted by the SEC that permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC. 

(c) The term “Holder” means any person owning Registrable Securities or any assignee thereof in accordance with Section 1.11
hereof and the Purchase Agreement. 
 (d) The term “Initial Offering” means the Company’s first firm commitment underwritten
public offering of its Common Stock under the Act. 
 (e) The term “1934 Act” means the Securities Exchange Act of 1934, as
amended. 
 (f) The term “register,” “registered,” and “registration” refer to a registration effected by
preparing and filing a registration statement or similar document in 

  
 1. 

 
compliance with the Act, and the declaration or ordering of effectiveness of such registration statement or document. 

(g) The term “Registrable Securities” means (1) the Common Stock issuable or issued upon conversion of the Company’s
Series E Preferred, (2) any securities issued pursuant to Section 2.4(b) hereof, (3) the Additional Shares issued pursuant to Section 1.12 hereof, and (4) any Common Stock of the Company issued as (or issuable upon the
conversion or exercise of any warrant, right or other security that is issued as) a dividend or other distribution with respect to, or in exchange for, or in replacement of, the shares referenced in (1), (2) and (3) above, excluding in all
cases, however, any Registrable Securities sold by a person (x) in a transaction in which his rights under this Section 1 are not assigned, (y) pursuant to a registration statement that has been declared effective and such Registrable
Securities have been disposed of pursuant to such effective registration statement, or (z) in a transaction in which such Registrable Securities are sold pursuant to Rule 144 (or any similar provision then in force) under the Act. 

(h) The number of shares of “Registrable Securities then outstanding” shall be determined by the number of shares of Common Stock
outstanding that are, and the number of shares of Common Stock issuable pursuant to then exercisable or convertible securities that are, Registrable Securities. 

(i) The term “SEC” shall mean the Securities and Exchange Commission. 

(j) The term “Significant Holder” shall mean the Holder of (1) shares of Registrable Securities having an aggregate original
purchase price of at least $1,000,000, or (2) any Common Stock of the Company issued as (or issuable upon the conversion or exercise of any warrant, right or other security that is issued as) a dividend or other distribution with respect to, or
in exchange for, or in replacement of, the shares referenced in (1) above. 
 (k) The term “Subsequent Series E Offering”
shall have the meaning set forth in the Purchase Agreement. 
 1.2 Request for Registration. 

(a) Subject to the conditions of this Section 1.2, if the Company shall receive at any time eighteen (18) months after the date of
this Agreement a written request from the Holders of fifty percent (50%) or more of the Registrable Securities then outstanding (the “Initiating Holders”) that the Company file a registration statement under the Act covering the
registration of Registrable Securities, then the Company shall, within twenty (20) days of the receipt thereof, give written notice of such request to all Holders, and subject to the limitations of this Section 1.2, use best efforts to
effect, as soon as practicable, the registration under the Act of all Registrable Securities that the Holders request to be registered in a written request received by the Company within twenty (20) days of the mailing of the Company’s
notice pursuant to this Section 1.2(a). 

 (b) If the Initiating Holders intend to distribute the Registrable Securities covered by their
request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 1.2 and the Company shall include such information in the written notice referred to in this Section 1.2(b). In
such event the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the
underwriting (unless otherwise mutually agreed by a majority in interest of the Initiating Holders and such Holder) to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall enter into an
underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by a majority in interest of the Initiating Holders (which underwriter or underwriters shall be reasonably acceptable to the Company);
provided, that if the registration statement relates to the Company’s Initial Offering, then underwriter or underwriters shall be selected for such underwriting by the Company (which underwriter or underwriters shall be reasonably acceptable to
a majority in interest of the Initiating Holders). 
 (c) Notwithstanding any other provision of this Section 1.2, if the underwriter
advises the Company that marketing factors require (i) a limitation of the number of securities underwritten or (ii) the exclusion of all or any portion of the Registrable Securities in the Initial Offering, then the Company shall so
advise all Holders of Registrable Securities that would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting, if any, shall be allocated to the Holders of such Registrable Securities on a pro
rata basis based on the number of (x) Registrable Securities held by all such Holders (including the Initiating Holders) and (y) securities of the Company held by other holders that have the right as of the date hereof (or hereafter
pursuant to Section 1.12 hereof) to require the Company to register securities on a registration statement filed pursuant to this Section 1.2; provided, that no Registrable Securities (or securities referred to in clause (y) above)
shall be excluded unless and until all other securities of the Company, including securities issued for the account of the Company, have been excluded, and provided further that, if a Registration Statement filed pursuant to this Section 1.2
relates to the Initial Offering, then Registrable Securities may be excluded from the offering hereunder before any securities issued for the account of the Company. Any Registrable Securities excluded or withdrawn from such underwriting shall be
withdrawn from the registration. 
 (d) The Company shall not be required to effect a registration pursuant to this Section 1.2: 

(i) in any particular jurisdiction in which the Company would be required to execute a general consent to service of process in effecting
such registration, unless the Company is already subject to service in such jurisdiction and except as may be required under the Act; or 

(ii) after the Company has effected two (2) registrations pursuant to this Section 1.2, and such registrations have been declared
or ordered effective (not including any registration in which more than 50% of the Registrable Securities that Holders 

 
request to be registered pursuant to Section 1.2(a) are excluded from such registration pursuant to Section 1.2(c)) ; or 

(iii) during the period starting with the date ninety (90) days prior to the Company’s good faith estimate of the date of the
filing of, and ending on a date one hundred eighty (180) days following the effective date of, a Company-initiated registration subject to Section 1.3 below, provided that the Company is actively employing in good faith all reasonable
efforts to cause such registration statement to become effective; or 
 (iv) if the Initiating Holders propose to dispose of Registrable
Securities that may be registered on Form S-3 pursuant to Section 1.4 hereof; or 
 (v) if the Company shall furnish to Holders
requesting a registration pursuant to this Section 1.2, a certificate signed by the Company’s Chief Executive Officer or Chairman of the Board stating that in the good faith judgment of the Board of Directors of the Company, it would be
seriously detrimental to the Company and its stockholders for such registration to be effected at such time, in which event the Company shall have the right to defer such filing for a period of not more than ninety (90) days after receipt of
the request of the Initiating Holders, provided that such right to delay a request shall be exercised by the Company not more than once in any twelve (12)-month period and provided further, that the Company shall not register any other of its shares
during such ninety (90) day period; or 
 (vi) if the Company has already effected any registration statement for the Holders within
the six (6) month period preceding the date of such request. 
 1.3 Company Registration. 

(a) If (but without any obligation to do so) the Company proposes to register (including for this purpose a registration effected by the
Company for stockholders other than the Holders) any of its capital stock under the Act in connection with the public offering of such securities (other than a registration relating solely to the sale of securities to participants in a Company stock
plan, a registration relating to a corporate reorganization or other transaction under Rule 145 of the Act, a registration on any form (including Form S-4 and Form S-8) that does not include substantially the same information as would be required to
be included in a registration statement covering the sale of the Registrable Securities, or a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered),
the Company shall, at such time, promptly give each Holder written notice of such registration. Upon the written request of each Holder given within twenty (20) days after mailing of such notice by the Company, the Company shall, subject to the
provisions of Section 1.3(c), use its best efforts to cause a registration statement to become effective, which includes all of the Registrable Securities that each such Holder has requested to be registered. 

(b) The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 1.3 prior to the
effectiveness of such registration whether or not any Holder has elected to include securities in such registration. The expenses of 

 
such withdrawn registration shall be borne by the Company in accordance with Section 1.7 hereof. 

(c) In connection with any offering involving an underwriting of shares of the Company’s capital stock, the Company shall not be
required under this Section 1.3 to include any of the Holders’ securities in such underwriting unless they accept the terms of the underwriting as agreed upon between the Company and the underwriters selected by it (or by other persons
entitled to select the underwriters) and enter into an underwriting agreement in customary form with an underwriter or underwriters selected by the Company. If (1) the total amount of securities requested by stockholders to be included in such
offering exceeds the amount of securities sold other than by the Company that the underwriters determine in their sole discretion is compatible with the success of the offering or (2) solely in the case of the Initial Offering, if the
underwriters determine that inclusion of the Registrable Securities will materially jeopardize the success of the Initial Offering, then the Company shall be required to include in the offering only that number of such securities, including
Registrable Securities, if any, that the underwriters determine in their sole discretion will not materially jeopardize the success of the offering. The securities included in such registration shall be apportioned pro rata among the selling Holders
and other security holders that have the right as of the date hereof (or hereafter pursuant to Section 1.12 hereof) to require registration of their shares in a registration statement under this Section 1.3, according to the total amount
of securities entitled to be included therein owned by each selling Holder and other holder or in such other proportions as shall mutually be agreed to by such selling Holders and other holders; provided, that no Registrable Securities (and
securities of the Company held by other holders that have rights as of the date hereof or acquired hereafter pursuant to Section 1.12 hereof) shall be excluded until all Common Stock held by other stockholders, directors, officers and employees
of the Company have been excluded, but in no event shall the amount of securities of the selling Holders included in the offering be reduced below twenty-five percent (25%) of the total amount of securities included in such offering, unless
such offering is the Initial Offering of the Company’s securities, in which case the selling Holders may be excluded if the underwriters make the determination described above and no other stockholder’s securities are included. For
purposes of the preceding parenthetical concerning apportionment, for any selling stockholder that is a Holder of Registrable Securities and that is a partnership or corporation, the partners, retired partners and stockholders of such Holder, or the
estates and family members of any such partners and retired partners and any trusts for the benefit of any of the foregoing persons shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to such
“selling Holder” shall be based upon the aggregate amount of Registrable Securities owned by all such related entities and individuals. 

1.4 Form S-3 Registration. In case the Company shall receive from the Holders of the Registrable Securities then outstanding a written
request or requests that the Company effect a registration on Form S-3 and any related qualification or compliance with respect to all or a part of the Registrable Securities owned by such Holder or Holders, the Company shall: 

(a) promptly give written notice of the proposed registration, and any related qualification or compliance, to all other Holders; and 

 (b) use best efforts to effect, as soon as practicable, such registration and all such
qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holders’ Registrable Securities as are specified in such request, together with all or such portion
of the Registrable Securities of any other Holders joining in such request as are specified in a written request given within fifteen (15) days after receipt of such written notice from the Company, provided, however, that the Company shall not
be obligated to effect any such registration, qualification or compliance, pursuant to this section 1.4: 
 (i) if Form S-3 is not
available for such offering by the Holders; 
 (ii) if the Holders, together with the holders of any other securities of the Company
entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public (net of any underwriters’ discounts or commissions) of less than $2,000,000; 

(iii) if the Company shall furnish to the Holders a certificate signed by the Chief Executive Officer or Chairman of the Board of the Company
stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall have
the right to defer the filing of the Form S-3 registration statement for a period of not more than ninety (90) days after receipt of the request of the Holder or Holders under this Section 1.4; provided, however, that the Company shall not
utilize this right more than once in any twelve (12) month period; and provided further, that the Company shall not register any other of its shares during such 90 day period; 

(iv) if the Company has already effected any registration statement for the Investors within the six (6) month period preceding the date
of such request, or two (2) registrations on Form S-3 for the Holders pursuant to this Section 1.4; or 
 (v) in any particular
jurisdiction in which the Company would be required to qualify to do business, where not otherwise required, or to execute a general consent to service of process in effecting such registration, qualification or compliance. 

(c) Subject to the foregoing, the Company shall file a registration statement covering the Registrable Securities and other securities so
requested to be registered as soon as practicable after receipt of the request or requests of the Holders. Registrations effected pursuant to this Section 1.4 shall not be counted as requests for registration effected pursuant to Sections 1.2.

 1.5 Obligations of the Company. 

Whenever required under this Section 1 to effect the registration of any Registrable Securities, the Company shall, as expeditiously as
reasonably possible: 

 (a) prepare and file with the SEC a registration statement with respect to such Registrable
Securities and use best efforts to cause such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement effective for a period
of up to one hundred twenty (120) days or, if earlier, until the distribution contemplated in the Registration Statement has been completed; 

(b) prepare and file with the SEC such amendments and supplements to such registration statement and the prospectus used in connection with
such registration statement as may be necessary to comply with the provisions of the Act with respect to the disposition of all securities covered by such registration statement; 

(c) furnish to the Holders (i) a draft copy of the registration statement, and (ii) such numbers of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them; 

(d) use best efforts to register and qualify the securities covered by such registration statement under such other securities or Blue Sky
laws of such jurisdictions as shall be reasonably requested by the Holders, provided that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business, where not otherwise required, or to file a
general consent to service of process in any such states or jurisdictions; 
 (e) in the event of any underwritten public offering, enter
into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter of such offering; 

(f) notify each Holder of Registrable Securities covered by such registration statement, at any time when a prospectus relating thereto is
required to be delivered under the Act, of (i) the issuance of any stop order by the SEC in respect of such registration statement, or (ii) the happening of any event as a result of which the prospectus included in such registration
statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing;

 (g) if the Registrable Securities are being sold through underwriters, furnish, upon the request of the Holders of a majority of the
Registrable Securities requesting registration, on the date that such Registrable Securities are delivered to the underwriters for sale, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such
registration, in form and substance as is customarily given to underwriters in an underwritten public offering and reasonably satisfactory to a majority in interest of the Holders requesting registration, addressed to the underwriters, and
(ii) a “comfort” letter dated as of such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an
underwritten public offering and reasonably satisfactory to a majority in interest of the Holders requesting registration, addressed to the underwriters. 

 (h) cause all such Registrable Securities registered pursuant hereunder to be listed on each
securities exchange on which similar securities issued by the Company are then listed; provided that in the case of a registration effected pursuant to Section 1.2 above, which registration constitutes the Initial Offering, the Registrable
Securities shall be listed on a national securities exchange or the NASDAQ National Market System; and 
 (i) provide a transfer agent and
registrar for all Registrable Securities registered pursuant hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration. 

1.6 Information from Holder. 

It shall be a condition precedent to the obligations of the Company to take any action pursuant to this Section 1 with respect to the
Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the Registrable Securities held by it, and the intended method of disposition of such securities as shall be reasonably
required to effect the registration of such Holder’s Registrable Securities. 
 1.7 Expenses of Registration. 

All expenses (other than underwriting discounts and commissions incurred in connection with registrations, filings or qualifications pursuant
to Sections 1.2, 1.3 and 1.4 and the fees and disbursements of counsel for the selling Holders), including (without limitation) all registration, filing and qualification fees (including Blue Sky fees), printers’ and accounting fees, fees and
disbursements of counsel for the Company, shall be borne by the Company. Notwithstanding the foregoing, the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to Section 1.2 or Section 1.4
if the registration request is subsequently withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered (in which case all participating Holders shall bear such expenses pro rata based upon the number of
Registrable Securities that were to be requested in the withdrawn registration), unless, in the case of a registration requested under Section 1.2, the Holders of a majority of the Registrable Securities agree to forfeit their right to one
demand registration pursuant to Section 1.2, provided, however, that if at the time of such withdrawal, the Holders have learned of a material adverse change in the condition, business or prospects of the Company from that known to the Holders
at the time of their request and have withdrawn the request with reasonable promptness following disclosure by the Company of such material adverse change, then the Holders shall not be required to pay any of such expenses and shall retain their
rights pursuant to Section 1.2 or 1.4. 
 1.8 Delay of Registration. 

No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result of any
controversy that might arise with respect to the interpretation or implementation of this Section 1. 

 1.9 Indemnification. 

In the event any Registrable Securities are included in a registration statement under this Section 1: 

(a) To the extent permitted by law, the Company will indemnify and hold harmless each selling Holder, the partners or officers, directors and
stockholders of each Holder, legal counsel, investment advisors and accountants for each Holder, any underwriter (as defined in the Act) for such Holder and each person, if any, who controls such Holder or underwriter, within the meaning of the Act
or the 1934 Act, against any losses, claims, damages or liabilities (joint or several) to which they may become subject under the Act, the 1934 Act or any state securities laws, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a “Violation”): (i) any untrue statement or alleged untrue statement of a material fact contained in such
registration statement, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission Or alleged omission to state therein a material fact required to be stated therein,
or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Act, the 1934 Act, any state securities laws or any rule or regulation promulgated under the Act, the 1934 Act or any
state securities laws; and the Company will reimburse each such Holder, partner, officer, director, stockholder, counsel, accountant, underwriter or controlling person for any legal or other expenses reasonably incurred by them in connection with
investigating or defending any such loss, claim, damage, liability or action as such expenses are incurred; provided, however, that the indemnity agreement contained in this subsection 1.9(a) shall not apply to amounts paid in settlement of any such
loss, claim, damage, liability or action if such settlement is effected without the consent of the Company (which consent shall not be unreasonably withheld), nor shall the Company be liable in any such case for any such loss, claim, damage,
liability or action to the extent that it arises out of or is based upon a Violation that occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such registration by any such Holder,
underwriter or controlling person; provided further, however, that the foregoing indemnity agreement with respect to any preliminary prospectus shall not inure to the benefit of any Holder or underwriter, or any person controlling such Holder or
underwriter, from whom the person asserting any such losses, claims, damages or liabilities purchased shares in the offering, if a copy of the prospectus (as then amended or supplemented if the Company shall have furnished any amendments or
supplements thereto) was not sent or given by or on behalf of such Holder or underwriter to such person, if required by law so to have been delivered, at or prior to the written confirmation of the sale of the shares to such person, and if the
prospectus (as so amended or supplemented) would have cured the defect giving rise to such loss, claim, damage or liability. 
 (b) To the
extent permitted by law, each selling Holder, on a several and not joint basis, will indemnify and hold harmless the Company, each of its directors, each of its officers who has signed the registration statement, each person, if any, who controls
the Company within the meaning of the Act, legal counsel and accountants for the Company, any underwriter, any other Holder selling securities in such registration statement and any controlling person of any such underwriter or other Holder, against
any losses, claims, damages or liabilities 

 
(joint or several) to which any of the foregoing persons may become subject, under the Act, the 1934 Act or any state securities laws, insofar as such losses, claims, damages or liabilities (or
actions in respect thereto) arise out of or are based upon any Violation, in each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with written information furnished by such Holder expressly
for use in connection with such registration; and each such Holder will reimburse any person intended to be indemnified pursuant to this subsection 1.9(b) for any legal or other expenses reasonably incurred by such person in connection with
investigating or defending any such loss, claim, damage, liability or action; provided, however, that the indemnity agreement contained in this subsection 1.9(b) shall not apply to amounts paid in settlement of any such loss, claim, damage,
liability or action if such settlement is effected without the consent of the Holder (which consent shall not be unreasonably withheld), provided that in no event shall any indemnity under this subsection 1.9(b) exceed the net proceeds from the
offering received by such Holder. 
 (c) Promptly after receipt by an indemnified party under this Section 1.9 of actual knowledge of
the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 1.9, deliver to the indemnifying party a written
notice of the commencement thereof. The indemnifying party shall promptly assume the defense of the indemnified party with counsel reasonably satisfactory to the indemnified party, and the fees and expenses of such counsel shall be at the sole cost
and expense of the indemnifying party. The indemnified party will cooperate with the indemnifying party in the defense of any action, proceeding, or investigation for which the indemnified party assumes the defense. Notwithstanding the foregoing,
the indemnified party shall have the right to employ separate counsel in any such action, proceeding, or investigation and to participate in the defense thereof, but the fees and expenses of such counsel shall be at the expense of the indemnified
party unless (i) the indemnifying party has agreed to pay such fees and expenses, (ii) the indemnifying party shall have failed promptly to assume the defense of such action, proceeding, or investigation and employ counsel reasonably
satisfactory to the indemnified party, or (iii) in the reasonable judgment of the indemnified party there may be one or more defenses available to the indemnified party which are not available to the indemnifying party with respect to such
action, claim, or proceeding due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such proceeding, in which case the indemnifying party shall not have the right to assume
the defense of such action, proceeding, or investigation on behalf of the indemnified party. The indemnifying party shall not be liable for the settlement by the indemnified party of any action, proceeding, or investigation effected without its
consent, which consent shall not be unreasonably withheld. The indemnifying party shall not enter into any settlement in any action, suit, or proceeding to which the indemnified party is a party, unless such settlement includes a general release of
the indemnified party with no payment by the indemnified party of consideration. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action, if prejudicial to its ability to defend
such action, shall relieve such indemnifying party of any liability to the indemnified party under this Section 1.9 to the extent of such prejudice, but the omission to so deliver written notice to the indemnifying party will not

 
relieve it of any liability that it may have to any indemnified party otherwise than under this Section 1.9. 

(d) If the indemnification provided for in this Section 1.9 is held by a court of competent jurisdiction to be unavailable to an
indemnified party with respect to any loss, liability, claim, damage or expense referred to herein, then the indemnifying party, in lieu of indemnifying such indemnified party hereunder, shall contribute to the amount paid or payable by such
indemnified party as a result of such loss, liability, claim, damage or expense in such proportion as is appropriate to reflect the relative fault of and the relative benefits received by the indemnifying party on the one hand and of the indemnified
party on the other in connection with the statements or omissions that resulted in such loss, liability, claim, damage or expense, as well as any other relevant equitable considerations, provided that no person guilty of fraud shall be entitled to
contribution. The relative fault of the indemnifying party and of the indemnified party shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material
fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission. The relative
benefits received by the indemnifying party and the indemnified party shall be determined by reference to the net proceeds and underwriting discounts and commissions from the offering received by each such party. In no event shall any contribution
under this subsection 1.9(d) exceed the net proceeds from the offering received by such Holder, less any amounts paid under subsection 1.9(b). 

(e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting
agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 

(f) The obligations of the Company and Holders under this Section 1.9 shall survive the completion of any offering of Registrable
Securities in a registration statement under this Section 1, and otherwise. 
 1.10 Reports Under Securities Exchange Act of
1934. 
 With a view to making available to the Holders the benefits of Rule 144 promulgated under the Act and any other rule or
regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company agrees to: 

(a) make and keep public information available, as those terms are understood and defined in SEC Rule 144, at all times after the effective
date of the Initial Offering; or 
 (b) file with the SEC in a timely manner all reports and other documents required of the Company under
the Act and the 1934 Act; and 

 (c) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon
request (i) a written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the first registration statement filed by the Company), the
Act and the 1934 Act (at any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies), (ii) a copy of the most
recent annual or quarterly report of the Company and such other reports and documents so filed by the Company, and (iii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC that
permits the selling of any such securities without registration or pursuant to such form. 

 1.11 Assignment of Registration Rights. 

The rights to cause the Company to register Registrable Securities pursuant to this Section 1 may be assigned (but only with all related
obligations) by a Holder to a transferee or assignee of such securities that (i) is a subsidiary, affiliate, parent, partner, limited partner, retired partner or stockholder of a Holder, (ii) is a Holder’s immediate family member
(spouse or child) or trust for the benefit of an individual Holder, or (iii) after such assignment or transfer, holds at least 250,000 shares of Registrable Securities (subject to appropriate adjustment for stock splits, stock dividends,
combinations and other recapitalizations), provided: (a) the Company is, within a reasonable time after such transfer, furnished with written notice of the name and address of such transferee or assignee and the securities with respect to which
such registration rights are being assigned, and provided further that the Company shall have no obligation to any transferee prior to receiving such notification of transfer; (b) such transferee or assignee agrees in writing to be bound by and
subject to the terms and conditions of this Agreement, including without limitation the provisions of Section 1.13 below; and (c) such assignment shall be effective only if immediately following such transfer the further disposition of
such securities by the transferee or assignee is restricted under the Act. 
 1.12 Limitations on Subsequent Registration Rights.

 From and after the date of this Agreement, the Company shall not, without the prior written consent of the Holders of fifty percent
(50%) of the then outstanding Registrable Securities, enter into any agreement with any holder or prospective holder of any securities of the Company that would allow such holder or prospective holder (a) to include such securities in any
registration filed under Sections 1.2 or 1.3 hereof, unless under the terms of such agreement, such holder or prospective holder may include such securities in any such registration only to the extent that the inclusion of such securities will not
reduce the amount of the Registrable Securities of the Holders that are included or (b) to demand registration of their securities. Notwithstanding the foregoing, the Company may grant rights to include securities in any registration filed
under Sections 1.2, 1.3 and 1.4 hereof to holders of shares of capital stock of equal priority to that of the Series E Preferred with an aggregate purchase price of up to $20,000,000 (the Additional Shares”), without such affirmative vote of
holders of the Series E Preferred. 
 1.13 “Market Stand-Off’ Agreement. 

Each Holder hereby agrees that it will not, without the prior written consent of the Company and the managing underwriter, during the period
commencing on the date of the final prospectus relating to the Company’s initial public offering and ending on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty (180) days)
(i) lend, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any
shares of Common Stock or any securities convertible into or exercisable or exchangeable for Common Stock (whether such shares or any such 

 
securities are then owned by the Holder or are thereafter acquired), or (ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic
consequences of ownership of the Common Stock or any securities convertible into or exercisable or exchangeable for Common Stock, whether any such transaction described in clause (i) or (ii) above is to be settled by delivery of Common
Stock or such other securities, in cash or otherwise. The foregoing provisions of this Section 1.13 shall apply only to the Initial Offering, shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement, and
shall only be applicable to the Holders if all officers and directors and greater than five percent (5%) stockholders of the Company enter into similar agreements. The underwriters in connection with the Company’s initial public offering
are intended third party beneficiaries of this Section 1.13 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. Notwithstanding the foregoing, nothing in this Section 1.13
shall prevent the undersigned from making a transfer of any Common Stock that was listed on a national stock exchange or traded on Nasdaq at the time it was acquired by the Holder or was acquired by the undersigned pursuant to Rule 144A of the Act,
including any shares acquired in the Company’s initial public offering. 
 In order to enforce the foregoing covenant, the Company may
impose stop-transfer instructions with respect to the Registrable Securities of each Holder (and the shares or securities of every other person subject to the foregoing restriction) until the end of such period. 

1.14 Termination of Registration Rights. 

No Holder shall be entitled to exercise any right provided for in this Section 1 after five (5) years following the consummation of
the Initial Offering or, as to any Holder, such earlier time at which all Registrable Securities held by such Holder (and any affiliate of the Holder with whom such Holder must aggregate its sales under Rule 144) can be sold in any three (3)-month
period in compliance with Rule 144 of the Act. 
 2. Covenants of the Company. 

2.1 Delivery of Financial Statements. 

(a) The Company shall deliver to each Significant Holder as soon as practicable after the end of each fiscal year of the Company, an income
statement for such fiscal year, a balance sheet of the Company and statement of stockholder’s equity as of the end of such year, and a statement of cash flows for such year, such year-end financial reports to be in reasonable detail, prepared
in accordance with generally accepted accounting principles (“GAAP”), and audited and certified by independent public accountants of nationally recognized standing selected by the Company, and an unqualified (except for contingent
liabilities) certified audit report from the Company’s auditors. 
 (b) The Company shall deliver to each Significant Holder 

(i) as soon as practicable after the end of each of the first three (3) quarters of each fiscal year of the Company, an unaudited income
statement, statement of 

 
cash flows for such fiscal quarter and an unaudited balance sheet as of the end of such fiscal quarter; 

(ii) as soon as practicable after approval by the Board of Directors, a budget for the next fiscal year, including balance sheets, income
statements and, as soon as prepared, any other budgets or revised budgets prepared by the Company and approved by the Board of Directors; and 

(iii) such other information relating to the financial condition, business, prospects or corporate affairs of the Company as such Significant
Holder may from time to time reasonably request. 
 (c) Together with the financial statements called for in Section 2.1(a) and (b),
the Company shall deliver an instrument executed by the Chief Financial Officer or President of the Company certifying that such financials were prepared in accordance with GAAP consistently applied with prior practice for earlier periods (with the
exception of footnotes that may be required by GAAP) and fairly present the financial condition of the Company and its results of operation for the period specified, subject to year-end audit adjustments and other reasonable qualifiers. 

2.2 Inspection. 
 The
Company shall permit each Significant Holder at such Significant Holder’s expense, to visit and inspect the Company’s properties, to examine its books of account and records and to discuss the Company’s affairs, finances and accounts
with its officers, all at such reasonable times as may be reasonably requested by the Investor; provided, however, that the Company shall not be obligated pursuant to this Section 2.2 to provide access to any information that it reasonably
considers to be a trade secret or similar confidential information. 
 2.3 Right of First Offer. 

(a) Subject to the terms and conditions specified in this Section 2.3, the Company hereby grants to each Investor a right of first offer
with respect to future sales by the Company of its Shares (as hereinafter defined). For purposes of this Section 2.3, Investor includes any partners and affiliates of an Investor. An Investor shall be entitled to apportion the right of first
offer hereby granted it among itself and its partners and affiliates in such proportions as it deems appropriate, so long as such apportionment does not cause the loss of the exemption under Section 4(2) of the Act or any similar exemption
under applicable state securities laws in connection with such sale of shares by the Company. 
 (b) Each time the Company proposes to
offer any shares of, or securities convertible into or exchangeable or exercisable for any shares of, any class of its capital stock (the “Shares”), the Company shall give written notice (the “Notice”) to the Investors at least
thirty (30) days before the closing of any such sale or transfer. The Notice shall describe in reasonable detail the proposed sale or transfer, including, without limitation (i) the number of such Shares to be offered, and (ii) the
price and terms upon which it proposes to offer such 

 
Shares, including voting powers and preferences. Each of the Investors shall have an option for a period of twenty (20) calendar days after receipt of the Notice, to purchase or obtain, at
the price and on the terms specified in the Notice, up to that portion of such Shares that equals the proportion that the number of shares of Common Stock issued and held, or issuable upon conversion of the Series E Preferred then held, by such
Investor bears to the total number of shares of Common Stock of the Company then outstanding (assuming full conversion and exercise of all outstanding convertible and exercisable securities). Each Investor may exercise its option by notifying the
Company within twenty (20) calendar days after receipt of the Notice of the number of securities its elects to purchase. Payment for the offered Shares shall be made by check or wire transfer against delivery of the offered Shares at a place
and time specified in the Notice, but in no event later than forty five (45) days after delivery of the Notice. If all Shares that Investors are entitled to obtain pursuant to this section are not elected to be obtained by the Investors, the
Company may, during the one hundred twenty (120) day period following the expiration of the twenty (20) day option period provided herein, offer the remaining unsubscribed portion of such Shares to any person or persons at a price not less
than, and upon terms no more favorable to the offeree than those specified in the Notice. If the Company does not enter into an agreement for the sale of the Shares within such one hundred twenty (120) day period, or if such agreement is not
consummated within one hundred twenty (120) days of the execution thereof, the right provided hereunder shall be deemed to be revived and such Shares shall not be offered unless first reoffered to the Investors in accordance herewith. 

(c) The right of first offer in this Section 2.3 shall not be applicable to bona fide options (and the shares issuable upon exercise
thereof) issued to employees, directors and consultants of the Corporation pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Corporation, (ii) shares issued in connection with the
exercise of convertible securities outstanding as of the date of the first sale of Series E Preferred, (iii) the issuance of securities in connection with a bona fide business acquisition of or by the Company, whether by merger, consolidation,
sale of assets, sale or exchange of stock or otherwise, (iv) the issuance of stock, warrants or other securities or rights to persons or entities with which the Company has business relationships provided such issuances are for other than
primarily equity financing purposes, provided that in cases of issuances pursuant to clauses (iii) and (iv) such issuances shall have been approved by a majority of the Board of Directors, (v) the issuance of shares of Series E
Preferred Stock in the Subsequent Offering (as defined in the Purchase Agreement), or (vi) the Company’s Initial Offering. 
 2.4
Reserved Share Pool; Additional Private Offering Purchase Option. 
 (a) The Company shall give written notice to each Investor as
soon as practicable, but in no event later than thirty (30) days, before the filing of the Company’s first registration statement with the Securities and Exchange Commission for resale of its securities. Upon a request made by Investors
holding a majority of the shares of Series E Preferred Stock after the filing of the Company’s first registration statement, the Company shall request that the managing underwriters of the Company’s Initial Offering establish a directed
share program (the “Program”) in connection with the Initial Offering covering at least 10% of the shares (or such lesser percentage as may be required by the National Association of Securities Dealers (the “NASD”) and applicable
regulatory authorities) offered in the Initial Offering (the “Program 

 
Shares”). The Company shall use its best efforts to cause the managing underwriters to (i) give priority to the holders of Series E Preferred Stock with respect to the Program Shares in
allocating the shares available for purchase in the Program so that the percentage of the total number of shares included in the Initial Offering made available to the holders of Series E Preferred Stock in the Program equals the percentage of
outstanding common shares on a fully diluted basis represented by the Series E Preferred Stock immediately prior to the closing of the Initial Offering and (ii) to implement the Program so that the holders of Series E Preferred Stock, pro rata
in accordance with their relative holdings of Series E Preferred Stock, have the option, but not the obligation, to purchase all or any portion of the Program Shares made available to them in clause (i) above at the Initial Offering price. 

(b) If the rights provided to the holders of Series E Preferred Stock under this section shall not be enforceable by them for any reason,
then the holders of Series E Preferred Stock shall have the option, but not the obligation, to purchase, and the Company hereby agrees to sell, the number of shares of common stock that such Investors would have otherwise been able to purchase under
Section 2.4(a) above in a private offering which shall close immediately prior to the consummation of the Initial Offering at the public offering price less a reasonable illiquidity discount to be determined by the parties in good faith, the
percentage of which discount shall not exceed the percentage underwriters’ discount for the Initial Offering. The timing and conditions of such private placement shall be as reasonably determined by the Investors holding a majority of the
Series E Preferred. Stock. The Company shall take all actions and execute and file all documents and instruments reasonably necessary to effectuate the private placement referred to in this Section 2.4(b). The securities issued to the Investors
in such private placement shall be deemed to be Registrable Securities, as such term is defined herein, and shall be subject to the rights and obligations provided to such securities herein. 

(c) Notwithstanding anything herein to the contrary, the rights provided to the holders of Series E Preferred Stock under this
Section 2.4 shall not be enforceable by them (a) to the extent they are found to be materially inconsistent with the regulations and policies of the SEC, the NASD or other regulatory authority as in effect at the time of the Initial
Offering, (b) would on the basis of SEC staff comments prevent the registration statement for the Initial Offering from being declared effective, (c) to the extent the managing underwriters determine that the exercise of such rights could
materially adversely effect the offering price in the Initial Offering or (d) if inclusion of such Program Shares or the consummation of such concurrent private offering could have the effect of causing the Initial Offering to fail to
constitute a bona fide good faith public distribution of the Initial Offering shares. 
 (d) The rights of the Investors granted by the
Company in this Section 2.4 have been bargained for as part of the investing practices of such Investors, and have not been sought by them or granted by the Company in contemplation of the Initial Offering to made within any determined period
of time (if ever made), but as an extension of the rights of first refusal granted to the Investors pursuant to Section 2.3 above that would otherwise expire upon and not apply to the Initial Offering. Each Investor may assign its rights under
this Section 2.4 to an affiliate of such Investor, a partner if such Investor is an investment fund, or to a beneficiary if such Investor is a trust. 

 2.5 Termination of Certain Covenants. 

The covenants set forth in this Section 2 (other than those in Section 2.4 above, which apply upon an Initial Offering and shall
terminate thereafter) shall terminate and be of no further force or effect following the consummation of the sale of securities pursuant to a bona fide, firmly underwritten public offering of shares of Common Stock, registered under the Act or when
the Company first becomes subject to the periodic reporting requirements of Sections 12(g) or 15(d) of the 1934 Act, whichever event shall first occur. 

2.6 Notice of Litigation. 

So long as any Holder shall hold any shares of Series E Preferred Stock, the Company shall provide notice to the Holders promptly upon the
filing of any material action, suit or proceeding. 
 2.7 Corporate Existence, Licenses and Permits; Maintenance of Properties. 

So long as any Holder shall hold any Series E Preferred Stock, the Company will at all times use commercially reasonable efforts to do or
cause to be done all things necessary to maintain, preserve and renew its existence as a corporation organized under the laws of a state of the United States of America, preserve and keep in force and effect, and cause each of its subsidiaries to
apply for on a timely basis, all licenses and permits necessary and material to the conduct of the business of the Company and its consolidated subsidiaries, taken as a whole, and to maintain and keep, and cause each of its subsidiaries to maintain
and keep, its and their respective material properties in good repair, working order and condition (except for normal wear and tear), and from time to time to make all needful and proper repairs, renewals and replacements, including, without
limitation, all trade name and trademark registration renewals, in each case so that any business material to the Company carried on in connection therewith may be properly conducted. 

2.8 No Investment Company. 

The Company shall not become an “investment company” or a company “controlled” by an “investment company,”
within the meaning of the Investment Company Act of 1940, as amended. In the event the Company breaches the foregoing, the Company shall forthwith notify the Investors and shall take immediate corrective action to remedy such breach. 

3. Miscellaneous. 
 3.1
Successors and Assigns. 
 Except as otherwise provided herein, the terms and conditions of this Agreement shall inure to the benefit
of and be binding upon the respective successors and assigns of the parties (including transferees of any shares of Registrable Securities). Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties
hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. 

 3.2 Governing Law. 

This Agreement shall be governed by and construed under the laws of the State of California as applied to agreements among California
residents entered into and to be performed entirely within California. 
 3.3 Counterparts. 

This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. From and after the date of this Agreement, the Company may allow additional Investors in the Subsequent Series E Offering and investors in any other offering approved by the holders of Series E Preferred in
accordance with the Certificate of Designation or allowable thereunder to become parties hereto by execution of the signature page by the Company and the new Investors. 

3.4 Titles and Subtitles. 

The titles and subtitles used in this Agreement are used for convenience only and are not to be considered in construing or interpreting this
Agreement. 
 3.5 Notices. 

Unless otherwise provided, any notice required or permitted under this Agreement shall be given in writing and shall be deemed effectively
given upon personal delivery to the party to be notified or upon delivery by confirmed facsimile transmission, nationally recognized overnight courier service, or upon deposit with the United States Post Office, by registered or certified mail,
postage prepaid and addressed to the party to be notified at the address indicated for such party on the signature page hereof, or at such other address as such party may designate by ten (10) days’ advance written notice to the other
parties. 
 3.6 Expenses. 

If any action at law or in equity is necessary to enforce or interpret the terms of this Agreement, the prevailing party shall be entitled to
reasonable attorneys’ fees, costs and necessary disbursements in addition to any other relief to which such party may be entitled. 

3.7 Entire Agreement; Amendments and Waivers. 

This Agreement (including the Exhibits hereto, if any) constitutes the full and entire understanding and agreement among the parties with
regard to the subjects hereof and thereof. Any term of this Agreement may be amended and the observance of any term of this Agreement may be waived (either generally or in a particular instance and either retroactively or prospectively), only with
the written consent of the Company and the holders of no less than a majority of the Registrable Securities then outstanding. Any amendment or waiver effected in accordance with this paragraph shall be binding upon each holder of any Registrable
Securities, each future holder of all such Registrable Securities and the Company. Notwithstanding the 

 
foregoing, any amendment of Section 1.13 shall require the consent of each Holder which is a registered investment company. 

3.8 Severability. 
 If
one or more provisions of this Agreement are held to be unenforceable under applicable law, such provision shall be excluded from this Agreement and the balance of the Agreement shall be interpreted as if such provision were so excluded and shall be
enforceable in accordance with its terms. 
 3.9 Aggregation of Stock. 

All shares of Registrable Securities held or acquired by entities advised by the same investment adviser and affiliated entities or persons
shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 
 3.10 Amendment and
Restatement. 
 Effective upon the Closing under the Purchase Agreement (as defined therein), the Initial Agreement shall be amended and
restated in its entirety as set forth herein. 

*        *        * 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Franklin California Growth Fund
		
	By:	 	 /s/ David P. Goss

		 	 David P. Goss
 Vice
President

			
		 	Address:	 	 777 Mariners Island Blvd.
 San Mateo, CA
94404

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Franklin Biotechnology Discovery Fund
		
	By:	 	 /s/ David P. Goss

		 	 David P. Goss
 Vice
President

			
		 	Address:	 	 777 Mariners Island Blvd.
 San Mateo, CA
94404

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	IDS Life Series Fund, Inc., – Equity Portfolio
		
		 	 /s/ [Illegible Signature]

			
		 	Address:	 	 c/o American Express Financial

Corporation
 733 Marquette Avenue

Minneapolis Minnesota 55402

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	AXP Strategy Aggressive Fund
		
		 	 /s/ [Illegible Signature]

			
		 	Address:	 	 c/o American Express Financial

Corporation
 733 Marquette Avenue

Minneapolis Minnesota 55402

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	AXP Strategy Aggressive Fund – Strategic Aggressive Fund
		
		 	 /s/ [Illegible Signature]

			
		 	Address:	 	 c/o American Express Financial

Corporation
 733 Marquette Avenue

Minneapolis Minnesota 55402

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Marc Pentopoulos

		 	 Marc Pentopoulos

		 	 EGM Medical Technology Fund LP

			
		 	Address:	 	 1 Embarcadero Center, Suite 2410
 SF CA
94111

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Marc Pentopoulos

		 	 Marc Pentopoulos

		 	 EGM Medical Technology Offshore Funds

			
		 	Address:	 	 1 Embarcadero Center, Suite 2410
 SF CA
94111

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Thomas M. Vertin

		 	 Thomas M. Vertin

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ T. Craig Benson

		 	 T. Craig Benson

		
		 	
                 

			
		 	Address:	 	  

		 		 	              

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 Lakeside Capital Group LLC

		 	 /s/ John S. Hemmingsen

		 	 John S. Hemmingsen

			
		 	Address:	 	 912 Riverside Circle
 Post Falls, ID
83854

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ John C. Dilts JQ

		 	 John C. Dilts JQ

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Ronald E. Clark

		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Ira Hall

		 	  

		
		 	 Ira Hall

			
		 	Address:	 	  

			
		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Lee Hall

		 	  

		
		 	 Lee Hall

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Kenneth Jay Hall

		 	 Kenneth Hall

		 	 /s/ Ellen Hall

		 	Ellen Hall
			
		 	Address:	 	  

			
		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ James A. Silverman

		 	          

		
		 	          

			
		 	Address:	 	  

			
		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Marilyn & Richard Snyder

		 	  

		
		 	 Marilyn & Richard Snyder

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Christine M. Cunningham

		 	 Christine M. Cunningham

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Steven J. Silverman

		 	 Steven J. Silverman

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Richard B. Silverman

		 	  

		
		 	 Richard B. Silverman

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ James A. Silverman

		 	 James A. Silverman Risk/Reward Capital Mgt. FBO

Katherine Burdon

		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Kenneth Sheiffer

		 	 Kenneth Sheiffer

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 The Johnson Living Trust

		 	  

		
		 	 /s/Peter Johnson, Trustee

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Sharlett Okylle

		 	 SHARLETT OKYLE

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Peter Suzman

		 	 Peter Suzman

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Erin M. Doran

		 	 Erin M. Doran

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard

South San Francisco, CA 94080
 650-866-7200
(phone)
 650-866-7202 (fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Antonio Marziale, Managing Director

		 	 Antonio Marziale, Managing Director

		
		 	 Heptagon Investments Ltd.

			
		 	Address:	 	 5, Rue Cesar Soulie

1206 Nyon (Switzerland)

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Antonio Marziale, Attorney in Fact

		 	 Antonio Marziale, Attorney in Fact

		
		 	 Financiera e Inversionista Xana S.A.

			
		 	Address:	 	 c/o Banco di Lugano
 Lugano
(Switzerland)

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Scott T. Jagodzinksi

		 	 Scott T. Jagodzinski

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Damian Topousis

		 	  

		
		 	 Damian Topousis

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Henry A. Cousineau III

		 	 Henry A. Cousineau III

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Paul D. Norell

		 	 Paul D. Norell

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Jeanne Capria

		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Peter Lecy

		 	 Peter Lecy

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 Financiera e Inversionista Xana S.A.

	By:	 	 Antonio Marziale, Attorney in Fact

		
		 	 /s/ Antonio Marziale, Attorney in Fact

		 	c/o Banco di Lugano Piazzetta San Carlo
		 	Address:	 	 6900 Lugano, Switzerland
 Attn:
Mr. Roberto Pini

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Bio Fund Ventures II Ky
		
	By:	 	 /s/ Kalevi Kurkijarvi

		 	 Kalevi Kurkijarvi, Chairman & CEO

		
		 	 (Bio Fund Management Oy as General Partner)

			
		 	Address:	 	 Mikonkatu 4
 00100 Helsinki

Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Thomproperties Oy
		
	By:	 	 /s/ Juha Jounki

		 	 Juha Jounki, Partner

		
		 	  

			
		 	Address:	 	 Italahoen Kotu 15-17
 00210 Helsinki,
Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Dreadnought Finance 04
		
	By:	 	 /s/ Juha Jounki

		 	 Juha Jounki

		
		 	  

			
		 	Address:	 	 Italahoenkatu 15-17
 00210 Helsinki,
Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Ulf Rosenlof

		 	 Ulf Rosenlof

		
		 	 Concordia Investor IKb

			
		 	Address:	 	 c/o Concordia Capital Ab
 Eteläesplanadi
22A
 Fin – 00130 Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Ulf Rosenlof

		 	 Ulf Rosenlof

		
		 	 Concordia Investor II Kb

			
		 	Address:	 	 c/o Concordia Capital Ab
 Eteläesplanadi
22A
 Fin – 00130 Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of Mehimas Oy

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of Servisen Holding AB

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin- 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of Eriksson Capital Ab

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of Aktiebolaget Svenpab

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of Piccolomini Oy

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of OyLipmed Ab

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of Oy Vivipharma Ab

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab on behalf of Ndlovu Ab

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Aki Prihti

		 	 Aki Prihti

		
		 	 Concordia Capital Ab

			
		 	Address:	 	 Eteläesplanadi 22A
 Fin – 00130
Helsinki
 Finland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Clifford J. Steer

		 	  

		
		 	 Clifford J. Steer

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Randolph C. Steer

		 	  

		
		 	 Randolph C. Steer

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/David W. Wynne

		 	 David W. Wynne

		
		 	  

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Michael S. Tankel

		 	 Michael S. Tankel

		
		 	  

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Susan Kingsolving

		 	 Susan Kingsolving

		
		 	  

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/C. Knox Massey, Jr.

		 	  

		
		 	 C. Knox Massey, Jr.

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Wirt L. Davis II

		 	 Wirt Davis II

		
		 	  

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/E. Carwile LeRoy

		 	 E. Carwil LeRoy

		
		 	  

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Robert J. Finegan

		 	  

		
		 	 Robert J. Finegan

			
		 	Address:	 	  

 

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 LSMFJ Partners

		 	 /s/Mike Salivas - Partner

		
		 	  

			
		 	Address:	 	 5970 Berkshire Lane, Suite 1300
 Dallas TX
75225

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Diana H. Adams

		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Joseph Rile

		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Robert E. Howard IV Ttee

		 	 Howard Children’s 1998 Trust

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Dan G. Howard Ttee

		 	 Howard Family Trust

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Frederick C. Goggans Family Partnership
		
	By:	 	 /s/ Frederick C. Goggans

		 	 Frederick C. Goggans

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Barbara B. Kaiser

		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ A.J. Brune, III

		 	 A.J. Brune, III

		
		 	 Chief Financial Officer and

Executive Vice President

			
		 	Address:	 	 300 N. Marienfeld, Suite 1100
 Midland, Texas
79701

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Cyril Wagner, Jr.

		 	 Cyril Wagner, Jr.

		 	 Managing Partner

Wagner Family Partnership VI

			
		 	Address:	 	300 N. Marienfeld, Suite 1100 Midland, Texas 79701

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Alex Gross

		 	 Alex Gross

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	/s/Gerardo LeGorreta
		 	 Gerardo LeGorreta

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	/s/John J. Mark
		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	/s/Carols Vizcaino
		 	  

		
		 	  

			
		 	Address:	 	 Tiro al Pichon 269
 Louvas de Bezares

Mexico DF 11901
 Mexico

			
		 		 	* *
			
		 		 	 Francisco Martinelli Bermudez Secretary & Director

Metro Gobal SA

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	CBG COMPAGNIE BANCAIRE GENEVE
		
	By:	 	 /s/ P.A.
Pesenti                    Th. Mory

		 	 Ass. Vice President             Ass.
Vice President

		
		 	  

			
		 	Address:	 	Avenue de Rumine 20
		 		 	CH-1005 Lausanne
		 		 	Switzerland

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Mr. Jorge CASO BERCHT

		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  

			
		 	
		 	 /s/ Diego Vignuda

		 	Diego Vignuda

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Thomas F. Kearns Jr.

		 	 Thomas F. Kearns Jr.

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/ Frank Deford

		 	  

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	 CITY NATIONAL BANK TTEE
 F.B.O.
PM&S / STEER

		
	By:	 	 /s/ John F.F. Billings

		 	 John F.F. Billings

		 	 Trust Officer

			
		 	Address:	 	225 Broadway St. #500
		 		 	S.D. CA 92101
		 		 	

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	CITY NATIONAL BANK TTEE F.B.O. PM&S / STEER
		
	By:	 	 /s/John F.F. Billings

		 	 John F.F. Billings

		 	 Trust Officer

 

			
		 	Address:	 	225 Broadway St. #500
		 		 	S.D. CA 92101

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/F.S. Reding

		 	 F.S Reding

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Mitsuru Hamaishi

		 	 Mitsuru Hamaishi

		 	 President

 

			
		 	Address:	 	6-3, Kanda Kajiojo 3-Ohome
		 		 	Ohiyoda-Ku, Tokyo 101 Japan
		 		 	Phone 03(3252)4591

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Isao Nishimura

		 	 ISAO NISHIMURA, President

		 	 Asahi Life Capital No.3 Investment

Enterprice Partnership

 

			
		 	Address:	 	7-3, Nishi-Shinjuku 1-Chome
		 		 	Shinjuku-ku, Tokyo 163-8611 JAPAN

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Masahiro Taguchi

		 	 MASAHIRO TAGUCHI, President

		
		 	 Sankyo Sekiyu Limited

			
		 	Address:	 	U.T. Building 8 Fr. 1-5-13
		 		 	Hirakawa-cho, Chiyoda-ku
		 		 	Tokyo, Japan 102-0093

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Kogin Investment (3iBJ) No. 2 Fund
		
	By:	 	 /s/Hajime Yosano

		 	 Hajime Yosano, President

		
		 	 IBJ Investment, ltd., Managing Kumiai-in

			
		 	Address:	 	12-2 Gobancho, Chiyoda,-ku,
		 		 	Tokyo, Japan

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Orix Fund No. 4
		
	By:	 	 /s/Tsutomu Matsuzaki

		 	 Tsutomu Matsuzaki, President, ORIX Capital Corporation

		 	 (Orix Fund No. 4)

 

			
		 	Address:	 	 TOC Osaki Bldg., 8F, 1-6-1
 Osaki,
Shinagawa-ku, Tokyo 141-0032

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
		 	Life Science Venture Fund
		
	By:	 	 /s/Tadashi Matsumoto

		 	 TADASHI MATSUMOTO, President & CEO

		
		 	 ReqMed Company, Ltd.

			
		 	Address:	 	 1-18-12 Mohino 2H
 Machida-City, Tokyo
194-0022

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/S.C Hong

		 	 President S.C. Hong

		
		 	 Chiatung Venture Capital Corporation

			
		 	Address:	 	10F., 261, Sung-Chiang Rd., Taipei Taiwan.

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Howard V. O’Connell

		 	 Howard V. O’Connell

		
		 	  

			
		 	Address:	 	  

		 		 	  

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/Lin, Yseng-Cheng

		 	 Lin, Yseng-Cheng

		
		 	 Chung Shan venture capital corporation

			
		 	Address:	 	 25F-2 NO.31 Hai-Pien
 Road Kaohsiung, Taiwan,
R.O.C.

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

					
		 	COMPANY:
		
		 	FIBROGEN, INC.
		
	By:	 	 /s/ Thomas B. Neff

		 	Thomas B. Neff, President and Chief Executive Officer
			
		 	Address:	 	 225 Gateway Boulevard
 South San Francisco,
CA 94080
 650-866-7200 (phone)
 650-866-7202
(fax)

  

					
		 	INVESTORS:
		
	By:	 	 /s/S.C. Hong

		 	 President S.C. Hong

		
		 	 Huitung Investment (BVI) Limited

			
		 	Address:	 	10F., 261, Sung-Chiang Rd., Taipei Taiwan.

  
 [SIGNATURE PAGE TO
FIRST AMENDED AND RESTATED 
 INVESTORS’ RIGHTS AGREEMENT] 

 FIBROGEN, INC. 

CONSENT AND WAIVER OF RIGHTS UNDER 

SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, In connection with the Series F Preferred Stock Financing of Fibrogen, Inc. (the “Company”), the Company wishes to issue
shares of Series F Preferred Stock of the Company and to grant registration rights to the purchasers of the Company’s Series F Preferred Stock (the “Series F Preferred”) by entering into the Series F Investor Rights Agreement to be
dated as of the date of the first closing of the Series F Preferred Stock Financing, a copy of which is attached hereto as Exhibit A, and to amend the Investors’ Rights Agreement dated May 12, 2000 between the Company and the Series
E Preferred stockholders (the “Investors’ Rights Agreement”) to place the holders of Series E Preferred on par with holders of Series F Preferred with respect to registration rights; 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock the Company holds a right of first offer with respect to
future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement; 
 WHEREAS, Pursuant to
Section 3.7 of the Investors’ Rights Agreement, the Investors’ Rights Agreement may be amended, and the right of first offer thereunder may be waived, by holders of a no less than a majority of the Registrable Securities outstanding;

 WHEREAS, Under Section 1.12 of the Investors’ Rights Agreement, the consent of holders of fifty percent (50%) of the
Registrable Securities is required to grant rights to demand registration rights or rights to include securities in registrations in any registration filed under Section 1.2 or 1.3 of the Investors’ Rights Agreement. 

NOW, THEREFORE, the undersigned Holder agrees as follows: 

1. Waiver. Holder hereby waives its rights pursuant to Section 2.3 of the Investors Rights Agreement with regard to the issuance
of up to 25,718,961 shares of Series F Preferred. 
 2. Consent and Amendment. Holder hereby consents to the grant of registration
rights to purchasers of Series F Preferred Stock of the Company under the Series F Investors’ Rights Agreement, including the inclusion of the Series E Preferred Stock in the definition of Registrable Securities under the Series F
Investors’ Rights Agreement, and to the amendment of the Investors Rights Agreement to conform to the registration rights set forth in the Series F Investors Rights Agreement, including the inclusion of the Series F Preferred Stock in the
definition of Registrable Securities. 
 3. Definitions. All terms not defined in this Consent and Waiver have the same meaning as
set forth in the Investors’ Rights Agreement. 
 [THE REMAINDER OF THIS PAGE LEFT BLANK INTENTIONALLY] 

  
 1 

 [THE REMAINDER OF THIS PAGE LEFT BLANK INTENTIONALLY] 

HOLDER: 
 VCFA HOLDINGS HI, LLC 

By: Venture Capital Fund America III, Inc., its managing member 
  

			
	By:	 	/s/ Brett D. Byers

			
	
	Brett D. Byers
	Name	 	
	
	Managing Director
	Title	 	

 Dated: December 21, 2004 

  
 [SIGNATURE PAGE TO
CONSENT AND WAIVER OF RIGHTS UNDER 
 SERIES E INVESTORS’ RIGHTS AGREEMENT] 

2. 

 HOLDER: 

VCFA HOLDINGS III, LLC 
 By: Venture Capital Fund of
America III, Inc. 
  

			
	By:	 	/s/ Brett D. Byers

			
	
	Brett D. Byers
	Name	 	
	
	Managing Director
	Title	 	

 Dated: December 14, 2004 

  
 [SIGNATURE PAGE TO
CONSENT AND WAIVER OF RIGHTS UNDER 
 SERIES E INVESTORS’ RIGHTS AGREEMENT] 

 FIBROGEN, INC. 

CONSENT AND WAIVER OF RIGHTS UNDER 

SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, In connection with the Series F Preferred Stock Financing of Fibrogen, Inc. (the “Company”), the Company wishes to issue
shares of Series F Preferred Stock of the Company and to grant registration rights to the purchasers of the Company’s Series F Preferred Stock (the “Series F Preferred”) by entering into the Series F Investor Rights Agreement to be
dated as of the date of the first closing of the Series F Preferred Stock Financing, a copy of which is attached hereto as Exhibit A, and to amend the Investors’ Rights Agreement dated May 12, 2000 between the Company and the Series
E Preferred stockholders (the “Investors’ Rights Agreement”) to place the holders of Series E Preferred on par with holders of Series F Preferred with respect to registration rights; 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock the Company holds a right of first offer with respect to
future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement; 
 WHEREAS, Pursuant to
Section 3.7 of the Investors’ Rights Agreement, the Investors’ Rights Agreement may be amended, and the right of first offer thereunder may be waived, by holders of a no less than a majority of the Registrable Securities outstanding;

 WHEREAS, Under Section 1.12 of the Investors’ Rights Agreement, the consent of holders of fifty percent (50%) of the
Registrable Securities is required to grant rights to demand registration rights or rights to include securities in registrations in any registration filed under Section 1.2 or 1.3 of the Investors’ Rights Agreement. 

NOW, THEREFORE, the undersigned Holder agrees as follows: 

1. Waiver. Holder hereby waives its rights pursuant to Section 2.3 of the Investors Rights Agreement with regard to the issuance
of up to 25,718,961 shares of Series F Preferred. 
 2. Consent and Amendment. Holder hereby consents to the grant of registration
rights to purchasers of Series F Preferred Stock of the Company under the Series F Investors’ Rights Agreement, including the inclusion of the Series E Preferred Stock in the definition of Registrable Securities under the Series F
Investors’ Rights Agreement, and to the amendment of the Investors Rights Agreement to conform to the registration rights set forth in the Series F Investors Rights Agreement, including the inclusion of the Series F Preferred Stock in the
definition of Registrable Securities. 
 3. Definitions. All terms not defined in this Consent and Waiver have the same meaning as
set forth in the Investors’ Rights Agreement. 
 [THE REMAINDER OF THIS PAGE LEFT BLANK INTENTIONALLY] 

  
 1 

 IN WITNESS WHEREOF, the undersigned stockholders of Fibrogen, Inc. have executed this Written
Consent in counterparts as of the date first set forth above and direct that this Written Consent be filed with the minutes of the proceedings of the stockholders of the Company. 

VCFA HOLDINGS III, LLC 
 By: Venture Capital Fund of America III,
Inc., its managing member 
  

			
	By:	 	/s/ Brett D. Byers

			
	Name:	 	Brett D. Byers
	Title:	 	Managing Director

 List of Exhibits: 

Exhibit A—Series F Certificate of Designation 

  
 [SIGNATURE PAGE TO
WRITTEN CONSENT OF SERIES E 
 STOCKHOLDERS OF FIBROGEN, INC.] 

 FIBROGEN, INC. 

CONSENT AND WAIVER OF RIGHTS UNDER 

SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, In connection with the Series F Preferred Stock Financing of Fibrogen, Inc. (the “Company”), the Company wishes to issue
shares of Series F Preferred Stock of the Company and to grant registration rights to the purchasers of the Company’s Series F Preferred Stock (the “Series F Preferred”) by entering into the Series F Investor Rights Agreement to be
dated as of the date of the first closing of the Series F Preferred Stock Financing, a copy of which is attached hereto as Exhibit A, and to amend the Investors’ Rights Agreement dated May 12, 2000 between the Company and the Series
E Preferred stockholders (the “Investors’ Rights Agreement”) to place the holders of Series E Preferred on par with holders of Series F Preferred with respect to registration rights; 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock the Company holds a right of first offer with respect to
future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement; 
 WHEREAS, Pursuant to
Section 3.7 of the Investors’ Rights Agreement, the Investors’ Rights Agreement may be amended, and the right of first offer thereunder may be waived, by holders of a no less than a majority of the Registrable Securities outstanding;

 WHEREAS, Under Section 1.12 of the Investors’ Rights Agreement, the consent of holders of fifty percent (50%) of the
Registrable Securities is required to grant rights to demand registration rights or rights to include securities in registrations in any registration filed under Section 1.2 or 1.3 of the Investors’ Rights Agreement. 

NOW, THEREFORE, the undersigned Holder agrees as follows: 

1. Waiver. Holder hereby waives its rights pursuant to Section 2.3 of the Investors Rights Agreement with regard to the issuance
of up to 25,718,961 shares of Series F Preferred. 
 2. Consent and Amendment. Holder hereby consents to the grant of registration
rights to purchasers of Series F Preferred Stock of the Company under the Series F Investors’ Rights Agreement, including the inclusion of the Series E Preferred Stock in the definition of Registrable Securities under the Series F
Investors’ Rights Agreement, and to the amendment of the Investors Rights Agreement to conform to the registration rights set forth in the Series F Investors Rights Agreement, including the inclusion of the Series F Preferred Stock in the
definition of Registrable Securities. 
 3. Definitions. All terms not defined in this Consent and Waiver have the same meaning as
set forth in the Investors’ Rights Agreement. 
 [THE REMAINDER OF THIS PAGE LEFT BLANK INTENTIONALLY] 

  
 1 

 HOLDER: 

FRANKLIN BIOTECHNOLOGY DISCOVERY FUND 

			
		
	By:	 	Evan McCulloch

			
	
	 Evan McCulloch

	Name	 	
	
	 Vice President

	Title	 	

 Dated: December     , 2004 

  
 [SIGNATURE PAGE TO
CONSENT AND WAIVER OF RIGHTS UNDER 
 SERIES E INVESTORS’ RIGHTS AGREEMENT] 

2 

 HOLDER: 

FRANKLIN FLEX CAP GROWTH FUND 

			
		
	By:	 	Evan McCulloch

			
	
	 Evan McCulloch

	Name	 	
	
	 Vice President

	Title	 	

 Dated: December 23, 2004 

  
 [SIGNATURE PAGE TO
CONSENT AND WAIVER OF RIGHTS UNDER 
 SERIES E INVESTORS’ RIGHTS AGREEMENT] 

2 

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 5th,
Sept, 2005 
 HOLDER: 
 Number of Series E Shares Held: 17400
Shares 
 Name: Oy Lipmed Ab (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Styrbjorn Sumelius

			
	
	 Mr. Styrbjorn Sumelius

	Name	 	
	
	 Man. Dir.

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Aug 23, 2005 

HOLDER: 
 Number of Series E Shares Held: 5600 

Name: Risk/Reward Capital FBO Katherine Burdon (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ [Illegible Signature]

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 31 August, 2005 

HOLDER: 
 Number of Series E Shares Held: 5600 

Name: Johnson Living Trust—U/T/A 24 February 1999 (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Peter Johnson

			
	
	 Peter Johnson

	Name	 	
	
	 Trustee

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 9/1, 2005 

HOLDER: 
 Number of Series E Shares Held: 5,567 

Name: Joanne Capria (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Joanne Capria

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: September, 1, 2005 

HOLDER: 
 Number of Series E Shares Held: class e - 42’710
- 
 Name:
                            (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ T. Mory
                                    /s/ L.
Roten

			
	
	 T. Mory
                                         
           L. Roten

	Name	 	
	
	 Vice Pres
                                        Ass. Vice
Pres.

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 24, 2005 

HOLDER: 
 Number of Series E Shares Held: 111,360 

Name: Ronald E & Sandra L. Clark, JT. (As it appears on Stock Certificate) 

							
				
	By:	 	/s/ Ronald E. Clark	  		  	 /s/ Sandra L. Clark

							
			
	 Ronald E. Clark
	  		 	 Sandra L. Clark

	Name	 		  		 	
			
	  
	  		 	
	Title	 		  		 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 29 August, 2005 

HOLDER: 
 Number of Series E Shares Held: 4,223 

Name: Gerardo Legorreta (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Gerardo Legorreta

			
	
	 Gerardo Legorreta

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 23 August, 2005 

HOLDER: 
 Number of Series E Shares Held: 5220 

Name: Concordia Capital Ab (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ [Illegible Signature]

			
	
	 [Illegible Name]

	Name	 	
	
	 President

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 23 August, 2005 

HOLDER: 
 Number of Series E Shares Held: 26100 

Name: Concordia Finance Oy (As it appears on Stock Certificate) 
  

			
	By:	 	/s/ [Illegible Signature]

			
	
	 [Illegible Name]

	Name	 	
	
	 President

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 9/26, 2005 

HOLDER: 
 Number of Series E Shares Held: 33,407 

Name: Henry A. Cousineau III (As it appears on Stock Certificate) 
  

			
		
	By:	 	/s/ Henry A. Cousineau III

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 26, 2005 

HOLDER: 
 Number of Series E Shares Held: 3,793 

Name: Wirt Davis II (As it appears on Stock Certificate) 
  

			
		
	By:	 	/s/ Wirt Davis II

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: September 5, 2005 

HOLDER: 
 Number of Series E Shares Held: 55,679 

Name: Asahi Life Capital No. 3 Investment Enterprise Partnership (As it appears on Stock Certificate) 

 

			
		
	By:	 	/s/ Sadao Suzuki

			
	
	 Sadao Suzuki

	Name	 	
	
	 President, Asahi Life Capital its Executive Partner

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 22, 2005 

HOLDER: 
 Number of Series E Shares Held: 111,360 

Name: Dreadnought Finance Oy (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Juna Jouhki

			
	
	 Juna Jouhki

	Name	 	
	
	 Chairman of the Board

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 9/6, 2005 

HOLDER: 
 Number of Series E Shares Held: 20817 

Name: Robert J. Finegan (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Robert J. Finegan

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Aug 22, 2005 

HOLDER: 
 Number of Series E Shares Held: All 

Name: Lakeside Capital Group (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ John J. Hemmingson

			
	
	 John Hemmingson

	Name	 	
	
	 Managing Partner

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Sept. 4, 2005 

HOLDER: 
 Number of Series E Shares Held: 10,430 

Name: /s/ Mark Gold /s/ Janice Gold (As it appears on Stock Certificate) 

			
		
	By:	 	Mark & Janice Gold

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 8/20, 2005 

HOLDER: 
 Number of Series E Shares Held: 948 

Name: Alex Gross (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Alex Gross

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated:
                , 2005 
 HOLDER: 

Number of Series E Shares
Held:                             

Name:
                                         
               (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Kenneth Jay Hall             /s/ Ellen Hall

			
	
	 Kenneth Jay Hall
                        Ellen Hall

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

 

	 	  	“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity compensation (and the shares issuable upon exercise thereof) issued to
employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock purchase plans, that have been approved by the stockholders of the
Corporation” 

 Dated: September 21, 2005 

HOLDER: 
 Number of Series E Shares Held: 2,227,171 Series
E                     
 Name: Hare & Co. FBO
Franklin California Growth Fund #180 (As it appears on Stock Certificate) 
  

			
		
	By:	 	/s/ David P. Goss

			
	
	 David P. Goss

	Name	 	

 Vice President & Assist. Secretary-Franklin Flex-Cap Growth Fund (formerly Franklin California Growth Fund) 

 Title 

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

 

	 	  	“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity compensation (and the shares issuable upon exercise thereof) issued to
employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock purchase plans, that have been approved by the stockholders of the
Corporation” 

 Dated: 9-19, 2005 
 HOLDER:

 Number of Series E Shares Held: 8,533 
 Name: Howard
Childrens Trust (As it appears on Stock Certificate) 
  

			
		
	By:	 	/s/ Robert E. Howard

			
	
	 Robert E. Howard

	Name	 	
	
	 TTEE

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

 

	 	  	“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity compensation (and the shares issuable upon exercise thereof) issued to
employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock purchase plans, that have been approved by the stockholders of the
Corporation” 

 Dated: 9-19, 2005 
 HOLDER:

 Number of Series E Shares Held:
8,534                             

Name: Howard Family Trust (As it appears on Stock Certificate) 
  

			
		
	By:	 	Dana K. Howard

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

 

	 	  	“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity compensation (and the shares issuable upon exercise thereof) issued to
employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock purchase plans, that have been approved by the stockholders of the
Corporation” 

 Dated: 9/1, 2005 
 HOLDER:

 Number of Series E Shares Held: 44,543 
 Name: Scott T.
Jagudzinski (As it appears on Stock Certificate) 
  

			
		
	By:	 	/s/ Scott T. Jagudzinski

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

 

	 	  	“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity compensation (and the shares issuable upon exercise thereof) issued to
employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock purchase plans, that have been approved by the stockholders of the
Corporation” 

 Dated:
                                         
   , 2005 
 HOLDER: 
 Number of Series E Shares
Held:
                                         
    
 Name: T. Craig Benson (As it appears on Stock Certificate) 

 

			
		
	By:	 	/s/ T. Craig Benson

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated:
7th September, 2005 
 HOLDER: 

Number of Series E Shares Held: 844721 
 Name: Bio Fund Ventures
II L.P. (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Kalevi Kurkijärvi

			
	
	 Kalevi Kurkijärvi

	Name	 	
	
	 General Partner

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Sept 14, 2005 

HOLDER: 
 Number of Series E Shares Held: 6,352 pref E 

Name: Susan Kingsolver (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Susan Kingsolver

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 25, 2005 

HOLDER: 
 Number of Series E Shares Held: 2111 

Name: Barbara Kaiser (As it appears on Stock Certificate) 

			
		
	By:	 	 

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated:
                    , 2005 
 HOLDER: 

Number of Series E Shares Held:
                                        

 Name: VCFA Holdings III, LLC (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Brett D. Byers

			
	
	 Brett D. Byers

	Name	 	
	
	 Managing Director of the Managing Member of Holder

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 8/25, 2005 

HOLDER: 
 Number of Series E Shares Held:
                                     

Name: Thomas Vertin (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Thomas Vertin

			
	
	 Thomas Vertin

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 9/7, 2005 

HOLDER: 
 Number of Series E Shares Held: 17400 

Name: Ndlova Ab (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Folke Husell

			
	
	 Folke Husell

	Name	 	
	
	  

	Title

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 23, 2005 

HOLDER: 
 Number of Series E Shares Held: 5,600 

Name: Sharlett O’Kyle (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Sharlett O’Kyle

			
	
	  

	Name	 	
	
	  

	Title

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 24, 2005 

HOLDER: 
 Number of Series E Shares Held: 9,733 

Name: Washington Research Foundation (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Beth G. Etscheid

			
	
	 Beth G. Etscheid

	Name	 	
	
	 Director of Licensing

	Title

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Aug 23, 2005 

HOLDER: 
 Number of Series E Shares Held: 21,117 

Name: Joseph P Riccardo (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Joseph P Riccardo

			
	
	  

	Name	 	
	
	  

	Title

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 08/28/, 2005 

HOLDER: 
 Number of Series E Shares Held: 23,705 

Name: Clifford J. Steer (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Clifford J. Steer

			
	
	  

	Name	 	
	
	  

	Title

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 8-22, 2005 

HOLDER: 
 Number of Series E Shares Held: 10,004 

Name: Michal Salinaro (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Michal Salinaro

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 8/27, 2005 

HOLDER: 
 Number of Series E Shares Held: 5600 

Name: Kenneth Sheiffe (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Kenneth Sheiffe

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: 08/24, 2005 

HOLDER: 
 Number of Series E Shares Held: 47,410 

Name: Randolph Steer (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Randolph Steer

			
	
	 Randolph Steer

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Aug 22, 2005 

HOLDER: 
 Number of Series E Shares Held: 20,000 

Name: James Silverman (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ James Silverman

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Aug 26, 2005 

HOLDER: 
 Number of Series E Shares Held: 16,500 

Name: Richard B Silverman (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Richard B Silverman

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: Aug 26, 2005 

HOLDER: 
 Number of Series E Shares Held: 5,600 

Name: Steven J Silverman (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Steven J Silverman

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 25, 2005 

HOLDER: 
 Number of Series E Shares Held:
                                 

Name: C. Knox Massey, Jr. (As it appears on Stock Certificate) 
  

			
		
	By:	 	/s/ C. Knox Massey, Jr.

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 22nd, 2005 

HOLDER: 
 Number of Series E Shares Held: 1000 

Name: Christopher McCampbell (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Christopher McCampbell

			
	
	  

	Name	 	
	
	  

	Title	 	

 CONSENT TO AMENDMENT 

OF SERIES E INVESTORS’ RIGHTS AGREEMENT 

WHEREAS, The undersigned holder (“Holder”) of Series E Preferred Stock of Fibrogen, Inc. (the “Company”) holds a right of
first offer with respect to certain future sales by the Company of its Shares pursuant to Section 2.3 of the Investors’ Rights Agreement dated May 12, 2000 (the “Investors’ Rights Agreement”); 

WHEREAS, Section 2.3(c)(i) of the Investors’ Rights Agreement provides that the right of first offer shall not apply to bona fide
options issued to employees, directors and consultants pursuant to written stock option or stock purchase plans that have been approved by the stockholders of the Company; 

WHEREAS, The Board of Directors of the Company has adopted and submitted to the stockholders of the Company for approval the 2005 Stock Plan,
which provides for the ability to issue a variety of forms of equity compensation in addition to bona fide options 
 WHEREAS, In order to
grant to employees, directors, consultants and other service providers the various forms of equity compensation issuable under the 2005 Stock Plan without the administrative inconvenience of offering such compensation to the Holders, the Company
hereby requests that the Holders consent to the amendment, under Section 3.7 if the Investors’ Rights Agreement, of Section 2.3 of the Investors’ Rights Agreement such that the right of first offer shall not apply to any form of
equity compensation issued under a written plan approved by the stockholders of the Company. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the undersigned Holder hereby agrees as follows: 
  

	 	1.	Amendment of Investors’ Rights Agreement. That Section 2.3(c)(i) of the Investors’ Rights Agreement is hereby amended to read as follows: 

“The right of first offer in this Section 2.3 shall not be applicable to (i) bona fide options and other forms of equity
compensation (and the shares issuable upon exercise thereof) issued to employees, directors and consultants or other service providers of the Corporation pursuant to written equity incentive plans, including stock option or stock
purchase plans, that have been approved by the stockholders of the Corporation” 
 Dated: August 22, 2005 

HOLDER: 
 Number of Series E Shares Held: 222.720 

Name: Thominvest Oy (As it appears on Stock Certificate) 

			
		
	By:	 	/s/ Juha Jounki

			
	
	 Juha Jounki

	Name	 	
	
	 President

	Title

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