Document:

EX-10.17

 Exhibit 10.17 

MASTER SUPPLY AND DEVELOPMENT SERVICES AGREEMENT 

between 
 ASTRAZENECA UK LIMITED

 and 
 VIELA BIO, INC. 

DATE: Febuaruy 23, 2018 
  

  
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 TABLE OF CONTENTS 
  

									
	1.	 	Agreement and Product Schedules	  	 	8	 
				
		 	1.1.	  	Agreement	  	 	8	 
				
		 	1.2.	  	Product Schedules	  	 	8	 
				
		 	1.3.	  	Non-Exclusive	  	 	8	 
				
		 	1.4.	  	Duration	  	 	8	 
			
	2.	 	Affiliates of AstraZeneca	  	 	9	 
				
		 	2.1.	  	Affiliates	  	 	9	 
			
	3.	 	AstraZeneca	  	 	9	 
				
		 	3.1.	  	AstraZeneca’s Performance	  	 	9	 
				
		 	3.2.	  	Breach of Quality Assurance Agreement	  	 	10	 
			
	4.	 	Intellectual Property	  	 	10	 
				
		 	4.1.	  	Intellectual Property Rights	  	 	10	 
				
		 	4.2.	  	Intellectual Property Rights of AstraZeneca	  	 	10	 
				
		 	4.3.	  	Arising Intellectual Property Rights	  	 	10	 
				
		 	4.4.	  	License of SPINCO Intellectual Property Rights	  	 	10	 
				
		 	4.5.	  	License to SPINCO	  	 	10	 
				
		 	4.6.	  	Proprietary Manufacturing Processes	  	 	11	 
				
		 	4.7.	  	Disclosure of CMC Information for Regulatory Purposes	  	 	11	 
				
		 	4.8.	  	Enforcement of Intellectual Property Rights	  	 	13	 
				
		 	4.9.	  	Defense of Third Party Claims	  	 	14	 
			
	5.	 	Delivery	  	 	14	 
				
		 	5.1.	  	Time of Delivery	  	 	14	 
			
	6.	 	Clinical Supply	  	 	15	 
				
		 	6.1.	  	Manufacture of Product for Clinical Trials	  	 	15	 
				
		 	6.2.	  	QAA	  	 	15	 
			
	7.	 	Inspection, Rejection and Acceptance of Supplied Product	  	 	15	 
				
		 	7.1.	  	Conforming Products	  	 	15	 
				
		 	7.2.	  	Release	  	 	15	 

  
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		 	7.3.	  	Shortfall or Non-Conforming Product	  	 	15	 
				
		 	7.4.	  	Remedies for Shortfall or Non-Conformance	  	 	16	 
				
		 	7.5.	  	Return or Destruction of Non-Conforming Products	  	 	16	 
				
		 	7.6.	  	Disagreement	  	 	16	 
				
		 	7.7.	  	Referral to Independent Expert	  	 	17	 
				
		 	7.8.	  	Recalls	  	 	17	 
			
	8.	 	Specifications; Change Control	  	 	18	 
			
	9.	 	Representations, Warranties and Information	  	 	20	 
				
		 	9.1.	  	Representations and Warranties	  	 	20	 
			
	10.	 	Payment	  	 	21	 
				
		 	10.1.	  	Prices	  	 	21	 
				
		 	10.2.	  	Invoices	  	 	21	 
				
		 	10.3.	  	Payment Period	  	 	21	 
				
		 	10.4.	  	Failure to Timely Pay	  	 	22	 
				
		 	10.5.	  	No Set-Off	  	 	22	 
				
		 	10.6.	  	Audits, Disputes, Requests for Information	  	 	23	 
			
	11.	 	Confidentiality	  	 	23	 
				
		 	11.1.	  	Confidentiality	  	 	23	 
				
		 	11.2.	  	Permitted Disclosure	  	 	24	 
				
		 	11.3.	  	Press Releases; Public Announcements	  	 	26	 
				
		 	11.4.	  	Injunctive Relief	  	 	26	 
				
		 	11.5.	  	Return or Destruction of Confidential Information	  	 	26	 
				
		 	11.6.	  	Permitted Retention of Confidential Information	  	 	26	 
			
	12.	 	Liability	  	 	27	 
				
		 	12.1.	  	Disclaimer	  	 	27	 
				
		 	12.3.	  	Limitation of Liability	  	 	27	 
				
		 	12.3.	  	Maximum Liability	  	 	27	 
				
		 	12.4.	  	Recovery of Damages	  	 	27	 
			
	13.	 	Indemnities	  	 	28	 
				
		 	13.1.	  	Indemnification of AstraZeneca	  	 	28	 
				
		 	13.2.	  	Indemnification of SPINCO	  	 	28	 

  
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		 	 13.3.
	  	 Exceptions and Limitations on Indemnification
	  	 	28	 
				
		 	 13.4.
	  	 Indemnification Procedures
	  	 	28	 
			
	 14.
	 	 Insurance
	  	 	29	 
				
		 	 14.1.
	  	 Insurance
	  	 	29	 
			
	 15.
	 	 Term and Termination
	  	 	29	 
				
		 	 15.1.
	  	 No Product Schedules
	  	 	29	 
				
		 	 15.2.
	  	 Term of Product Schedule
	  	 	29	 
				
		 	 15.3.
	  	 Product Schedule Termination on Notice
	  	 	29	 
				
		 	 15.4.
	  	 For Convenience
	  	 	29	 
				
		 	 15.5.
	  	 Material Breach
	  	 	30	 
				
		 	 15.6.
	  	 Insolvency Events
	  	 	30	 
				
		 	 15.7.
	  	 Technology Transfer:
	  	 	30	 
				
		 	 15.8.
	  	 Force Majeure
	  	 	30	 
				
		 	 15.9.
	  	 Survival of Rights and Obligations
	  	 	31	 
			
	 16.
	 	 Force Majeure
	  	 	31	 
				
		 	 16.1.
	  	 Force Majeure
	  	 	31	 
			
	 17.
	 	 Assignment, Transfer and Subcontracting
	  	 	31	 
				
		 	 17.1.
	  	 Assignment
	  	 	31	 
				
		 	 17.2.
	  	 Subcontracting
	  	 	33	 
			
	 18.
	 	 Notices
	  	 	33	 
				
		 	 18.1.
	  	 Form of Notice
	  	 	33	 
				
		 	 18.2.
	  	 Address for Notice
	  	 	34	 
			
	 19.
	 	 General
	  	 	34	 
				
		 	 19.1.
	  	 Relationship of Parties
	  	 	34	 
				
		 	 19.2.
	  	 Waivers
	  	 	34	 
				
		 	 19.3.
	  	 Severability
	  	 	34	 
				
		 	 19.4.
	  	 Entire Agreement
	  	 	34	 
				
		 	 19.5.
	  	 No Reliance
	  	 	35	 
				
		 	 19.6.
	  	 Amendments and Modifications
	  	 	35	 
				
		 	 19.7.
	  	 Third Parties
	  	 	35	 
				
		 	 19.8.
	  	 Counterparts
	  	 	35	 

  
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		 	 19.9.
	  	 Jurisdication and Dispute Resolution
	  	 	35	 
				
		 	 19.10.
	  	Governing Law	  	 	36	 
				
		 	 19.11.
	  	Equitable Relief	  	 	36	 
			
	 20.
	 	 Oversight
	  	 	37	 
				
		 	 20.1.
	  	 Project Teams
	  	 	37	 
				
		 	 20.2.
	  	 Joint Development Committee
	  	 	37	 
				
		 	 20.3.
	  	 Joint Steering Committee
	  	 	37	 
				
		 	 20.4.
	  	 Procedural Matters
	  	 	38	 
			
	 21.
	 	 Compliance
	  	 	38	 
				
		 	 21.1.
	  	 Authorization
	  	 	38	 
			
	 22.
	 	 Safety, Health and Environment
	  	 	38	 
				
		 	 22.1.
	  	 Health, Safety and Security Rules
	  	 	38	 
				
		 	 22.2.
	  	 Hazards
	  	 	38	 
				
		 	 22.3.
	  	 Registrations and Approvals
	  	 	38	 
			
	 23.
	 	 Records, Monitoring and Right to Audit
	  	 	38	 
				
		 	 23.1.
	  	 Records
	  	 	38	 
				
		 	 23.2.
	  	 Audit
	  	 	39	 
				
		 	 23.4.
	  	 Audit Assistance
	  	 	39	 
				
		 	 23.4.
	  	 Audit Costs
	  	 	39	 

  

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 MASTER SUPPLY AND DEVELOPMENT SERVICES AGREEMENT 

This Master Supply and Development Agreement (the “Agreement”) is entered into as of Febuary 23, 2018 (the “Effective Date”)
by and between: 
 ASTRAZENECA UK LIMITED, a company incorporated under the laws of England and Wales, whose registered office is at 1 Francis Crick
Avenue, Cambridge Biomedical Campus, Cambridge, Cambridgeshire, United Kingdom, CB2 0AA (“AstraZeneca”); and 
 VIELA BIO, INC., a
Delaware corporation, whose registered office is at 1209 Orange Street, Wilmington, New Castle County, Delaware, 19801 (“SPINCO”); 
 (each
a “Party”, collectively the “Parties”). 
 Background 

 

	(A)	 AstraZeneca has established research, development and/or manufacturing programs for MEDI-551 (the “MEDI-551 Program”), MEDI4920, MEDI7734, MEDI9600, MEDI1116 and Mabkine (collectively, including the
MEDI-551 Program, the “Programs”) aimed at treating inflammation and autoimmune disorders. 

  

	(B)	 Certain Affiliates of AstraZeneca and SPINCO have entered into that certain Asset Purchase Agreement, dated
February 23, 2018 (the “APA”), pursuant to which MedImmune, LLC, MedImmune Limited and AstraZeneca Collaboration Ventures, LLC, have agreed to sell certain assets relating to the Programs to SPINCO on the terms and subject to
the conditions set forth therein. 

  

	(C)	 In accordance with the terms and conditions of the APA, AstraZeneca and SPINCO have agreed to enter into
(a) a clinical supply agreement for the supply of MEDI-551 and related services which it is anticipated will be provided initially by AstraZeneca Operations (“CSA”); (b) an agreement for
the supply of development services for the Programs and the supply of clinical and non-clinical product for the Programs (excluding supply of MEDI-551, which MEDI-551 supply will occur under the CSA and MEDI1116, which MEDI1116 clinical supply (and if applicable commercial supply) will occur under one or more separate supply agreements to be entered into by the Parties),
which it is anticipated will be provided initially by MedImmune’s Biopharmaceutical Development function; and (c) a subsequent commercial supply agreement for MEDI-551 to be negotiated in good faith
between the Parties. 

  
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	(D)	 Further to recital (C)(b) above, SPINCO has agreed to enter into this Agreement to enable it to obtain
(a) such development services for the Programs (and such other programs as the Parties may agree from time to time) and (b) clinical and non-clinical supplies for the Existing Products (and such
other products as the Parties may agree from time to time, but not including MEDI-551 or MEDI1116), in each case from AstraZeneca or its Affiliates or subcontractors through Product Schedules entered into
under this Agreement. 

 Execution 

This Agreement is executed as of the Effective Date by the authorized representatives of the Parties. 

 

			
	 SIGNED for and on behalf of
 AstraZeneca UK
Limited
	  	 SIGNED for and on behalf of
 Viela Bio,
Inc.

  

									
	By:	 	[***]	 		 	By:	 	 /s/ Zhengbin (Bing) Yao

	Name:	 	[***]	 		 	Name:	 	Zhengbin (Bing) Yao
	Title:	 	[***]	 		 	Title:	 	CEO
	Date:	 		 		 	Date:	 	

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 Agreement 

In consideration of the premises and the mutual promises and conditions set forth herein and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, do hereby agree as follows: 
 PART A: GENERAL TERMS 

1.    Agreement and Product Schedules 

1.1.    Agreement: This Agreement sets out the terms on which AstraZeneca agrees to supply or cause its Affiliate to supply, and
under which SPINCO agrees to purchase, supplies of Products and Development Services pursuant to the applicable Product Schedules. 

1.2.    Product Schedules: SPINCO and AstraZeneca may enter into: 

1.2.1.    Development Service Schedules for development activities in relation to Products; and 

1.2.2.    Supply Schedules for the supply of Products (and services related to such supply); 

The terms and conditions of this Agreement (including any subsequent amendments) shall be, and hereby are deemed to be, incorporated into each Product
Schedule, and each Product Schedule shall form a separate Agreement. 

1.3.    Non-Exclusive: The engagement of AstraZeneca by SPINCO under a Product Schedule
shall be on a non-exclusive basis. SPINCO shall at all times have the right, at its sole discretion, to engage other service providers in relation to any Products; provided, however, that with respect to the
supply of Products, such right shall be expressly subject to Section 4.6 of this Agreement. Except as provided in Section 4.7 or to the extent agreed in connection with a technology transfer pursuant to Section 15.7, in no event shall
any Service provided by AstraZeneca or its Affiliates or subcontractors hereunder require disclosure or transfer of any MedImmune Manufacturing Technology. 

1.4.    Duration: SPINCO and AstraZeneca may enter into Product Schedules at any time during the ten (10) year period
beginning on the Effective Date. The expiry of that ten (10) year period or the termination of this Agreement under Article 15 (Term and Termination) will not automatically result in the termination or expiry of any Product Schedule.

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 2.    Affiliates of AstraZeneca 

2.1.    Performance by Affiliates. AstraZeneca shall have the right to perform all or any of its obligations under this Agreement
through any of its Affiliates provided that AstraZeneca shall remain responsible for the performance of such Affiliate as if such obligations were performed by AstraZeneca itself.

2.2.    Affiliates: SPINCO and AstraZeneca or any Affiliate of AstraZeneca may enter into: 

2.2.1.    Development Service Schedules for Development Services; and 

2.2.2.    Supply Schedules for the supply of Products; 

and the terms and conditions of this Agreement (including any subsequent amendments) shall be, and hereby are deemed to be, incorporated into
each Affiliate Product Schedule, subject to the following variations and any other variations set out in that Affiliate Product Schedule. Under all circumstances, AstraZeneca will remain fully liable for all obligations under this Agreement on
behalf of itself and its Affiliates. An Affiliate Product Schedule shall form a separate agreement between SPINCO and the Affiliate of AstraZeneca. For each Affiliate Product Schedule the terms and conditions shall be varied so that references to
“AstraZeneca” will be construed as references to the Affiliate and references to “Parties” construed accordingly. For the avoidance of doubt, no Affiliate of AstraZeneca shall be bound by the terms of this Agreement unless such
Affiliate has entered into an Affiliate Product Schedule. 
 3.    AstraZeneca Obligations 

3.1.    AstraZeneca’s Performance: AstraZeneca shall carry out the Services in accordance with the terms of this Agreement,
including the applicable: 
 3.1.1.    Purchase Order; 

3.1.2.    QAA; 

3.1.3.    Product Schedule; and 

3.1.4.    Applicable Laws and Regulations. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 3.2.    Breach of Quality Assurance Agreement: A breach of the QAA constitutes a
breach of this Agreement. If there is any inconsistency between the QAA and this Agreement, the QAA shall take precedence for all quality matters and this Agreement for all other matters. 

4.    Intellectual Property 

4.1.    Intellectual Property Rights of SPINCO: All Background IPR of SPINCO shall remain vested in and the exclusive property of
SPINCO or its licensors, as applicable. 
 4.2.    Intellectual Property Rights of AstraZeneca: All Background IPR of AstraZeneca
or its Affiliates shall remain vested in and the exclusive property of AstraZeneca, its Affiliates or its licensors, as applicable. 

4.3.    Arising Intellectual Property Rights: Intellectual Property Rights arising in connection with the activities undertaken
pursuant to this Agreement (“Arising IPR”) shall be owned according to inventorship; provided that to the extent that any Arising IPR conceived, developed or generated by AstraZeneca or an Affiliate of AstraZeneca relates
exclusively to a Product, such Arising IPR will be owned by SPINCO (“New SPINCO IPR”). AstraZeneca shall promptly disclose to SPINCO all Know-How that relates exclusively to a Product, and
SPINCO shall have the sole discretion in pursuing Patent Rights or other intellectual property rights protection for such Know-How. AstraZeneca hereby assigns to SPINCO all right, title and interest of
AstraZeneca in any New SPINCO IPR. With the exception of New SPINCO IPR, all Arising IPR conceived, developed or generated by AstraZeneca or an Affiliate of AstraZeneca (“New AZ IPR”) will be owned by AstraZeneca. 

4.4.    License of SPINCO Intellectual Property Rights: SPINCO grants to AstraZeneca a royalty-free,
non-exclusive right for the term of this Agreement to use and sublicense SPINCO’s Intellectual Property Rights, including the New SPINCO IPR to the extent necessary and for the sole purpose of performing
its obligations under this Agreement. 
 4.5.    License to SPINCO: Provided that this Agreement has not been terminated
by AstraZeneca under Section 15.5 due to material breach by SPINCO, AstraZeneca hereby grants to SPINCO a non-exclusive, royalty-free, sublicensable, worldwide license to use any (a) New AZ IPR
(other than any Manufacturing Technology) and (b) Licensed Manufacturing Technology, in each case (a) and (b) solely to the extent necessary to make, have made, use, sell, offer to sell and import Products. This Section 4.5 is without
prejudice to Section 4.6 and SPINCO’s obligations of non-use and non-disclosures in Article 11 (Confidentiality). 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 4.6.    Proprietary Manufacturing Processes: 

4.6.1.    SPINCO acknowledges and agrees that the manufacturing process used by AstraZeneca or its Affiliates to
manufacture each of the Existing Products incorporates or may incorporate Manufacturing Technology and that AstraZeneca is under no obligation to transfer such Manufacturing Technology to SPINCO or, subject to Section 15.7, any Third Party. The
Parties anticipate that, as part of the Development Services, AstraZeneca will develop manufacturing processes for the Existing Products (other than MEDI-551 and MEDI1116) that, notwithstanding the foregoing,
can and will be transferred to SPINCO in accordance with the applicable Product Schedule (the “Transferable Manufacturing Processes”). 

4.6.2.    The Transferable Manufacturing Processes shall not include or use Manufacturing Technology, except Manufacturing
Technology that (a) is subject to one or more Sublicense Agreements (as defined in and entered into pursuant to the APA); (b) the Parties have mutually agreed to include or use in such process on such terms as may be agreed between the Parties
and recorded in the applicable Product Schedule; or (c) is not subject to clause (b) but is included or used in such process, in which case such Manufacturing Technology under this clause (c) (the “Licensed Manufacturing
Technology”) shall be licensed to SPINCO pursuant to Section 4.5; 
 4.6.3.    AstraZeneca will, subject to
the terms of the applicable Product Schedule, transfer each Transferable Manufacturing Process to either SPINCO, or, subject to the terms of the Sublicense Agreements (if applicable), such Third Party as SPINCO may direct. 

4.6.4.    SPINCO acknowledges and agrees that a Transferable Manufacturing Process may [***]. 

4.6.5.    For clarity, AstraZeneca is under no obligation to (a) use or include any particular elements of
Manufacturing Technology, including [***] in the performance of the Development Services, or (b) subject to Sections 4.7 and 15.7, disclose or otherwise transfer any MedImmune Manufacturing Technology.  

4.7.    Disclosure of CMC Information for Regulatory Purposes:  

4.7.1.    With respect to each Existing Product, if and for so long as Supplied Product is manufactured by AstraZeneca
using MedImmune Manufacturing 

  
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Technology, AstraZeneca will, at SPINCO’s reasonable request, and at SPINCO’s [sole] cost and expense, provide SPINCO one or more letters providing SPINCO a right of reference to the
relevant IND or other relevant filing with a Regulatory Authority, or shall otherwise provide SPINCO via such other methods as may be available, to allow SPINCO to reference with the applicable Regulatory Authority the relevant CMC Data solely to
the extent necessary for SPINCO to obtain or maintain an IND or BLA or other Regulatory Approval for such Product. Such alternate methods may entail AstraZeneca providing such CMC Data directly to such Regulatory Authority (to the extent permitted
by Applicable Law and Regulations) or at AstraZeneca’s sole election, directly to SPINCO; provided that SPINCO shall permit AstraZeneca to seek any and all measures available to protect the confidentiality of and AstraZeneca’s interests in
and to such CMC Data, including, if such information is provided directly to SPINCO, restricting access to such CMC Data through a secure data room or portal to specified members of SPINCO’s regulatory affairs and quality assurance departments
who need to know such CMC Data in order to prepare, submit, obtain, or maintain an IND or BLA or Regulatory Approval for the Product and who have entered into confidentiality agreements with AstraZeneca in a form reasonably acceptable to
AstraZeneca, and SPINCO shall provide full cooperation and assistance to AstraZeneca in seeking to obtain such protection. 

4.7.2.    If required by AstraZeneca, the cover letter for any IND or other Regulatory Approval application submitted by
SPINCO in connection with this Agreement shall instruct the applicable Regulatory Authority to direct any questions with respect to the CMC Data for the Product directly to AstraZeneca. If, in connection with obtaining or maintaining any IND or
other Regulatory Approval for the Product, SPINCO receives any question from a Regulatory Authority with respect to the CMC Data for the Existing Product or otherwise in connection with any MedImmune Manufacturing Technology, unless AstraZeneca has
specified otherwise, SPINCO shall not answer any such question and shall promptly forward such question to AstraZeneca and unless AstraZeneca has specified otherwise, AstraZeneca shall, where this is permissible, provide the answer to any such
question directly to the applicable Regulatory Authority. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 4.7.3.    For clarity, (a) if AstraZeneca provides a right of
reference, or such other method for SPINCO to utilize the CMC Data other than providing such CMC Data directly to specified personnel at SPINCO, such reference or other method shall not entitle SPINCO to view, access, or otherwise obtain such CMC
Data or any other MedImmune Manufacturing Technology; and (b) to the extent that MedImmune Manufacturing Technology is disclosed pursuant to this Section 4.7, it may not be further disclosed within SPINCO, to an Affiliate or to any Third
Party except to: 
  

	 	(a)	 a Regulatory Authority as permitted pursuant to Section 4.7.2 to the extent necessary to obtain or
maintain a Regulatory Approval for such Product; provided, however, that reasonable measures shall be taken to assure confidential treatment of such MedImmune Manufacturing Technology and SPINCO shall not disclose any MedImmune Manufacturing
Technology to any Regulatory Authority or answer any query raised by a Regulatory Authority with respect to MedImmune Manufacturing Technology unless SPINCO has provided a copy of the query (or other explanation of the need to disclose) and proposed
disclosure or response to AstraZeneca and AstraZeneca has given its written consent to such proposed disclosure or response; or 

  

	 	(b)	 the extent required pursuant to Section 11.2.3, as provided therein. 

4.7.4.    NOTWITHSTANDING ANY OTHER PROVISION IN THIS AGREEMENT, EXCEPT AS EXPRESSLY PROVIDED IN THIS SECTION 4.7,
SPINCO SHALL NOT USE OR DISCLOSE MEDIMMUNE MANUFACTURING TECHNOLOGY FOR ANY PURPOSE. 
 4.8.    Enforcement of Intellectual Property
Rights: If any Party learns of the actual, suspected, threatened or likely infringement or misappropriation of any Intellectual Property Rights of either Party (including the Arising IPR) relating to any Supplied Product or the Services, then
that Party shall give written notice thereof to the other Party, and shall provide the other Party with any evidence of such infringement or misappropriation in its possession. SPINCO shall have the right to enforce any rights in SPINCO’s
Background IPR and New SPINCO IPR against any infringement or misappropriation, and to defend any Third Party challenge to its Background IPR or New SPINCO IPR, and may at its own expense, institute suit against any such infringer or misappropriator
or defend any challenge to its Intellectual Property Rights, and shall control and defend such suit and recover any damages, awards, or 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 
settlements remaining after deduction of the reasonable and documented, out-of-pocket costs (including
attorney’s fees and expenses) of each Party in assisting with such suit. AstraZeneca will reasonably cooperate in any such litigation, including, without limitation, joining any such suit, at SPINCO’s request and expense. SPINCO shall not
enter into any settlement of any claim described in this Section 4.8 that incurs any financial liability on the part of AstraZeneca or requires an admission of liability, wrongdoing or fault on the part of AstraZeneca, without
AstraZeneca’s prior written consent (such consent not to be unreasonably withheld, delayed, or conditioned). 
 AstraZeneca shall have the right to
enforce any rights in AstraZeneca’s Background IPR and New AZ IPR against any infringement or misappropriation, and defend any Third Party challenge to its Background IPR or New AZ IPR, and may at its own expense, institute suit against any
such infringer or misappropriator, and control and defend such suit and recover any damages, awards, or settlements remaining after deduction of the reasonable and documented,
out-of-pocket costs (including attorney’s fees and expenses) of each Party in assisting with such suit. SPINCO will reasonably cooperate in any such litigation,
including, without limitation, joining any such suit, at AstraZeneca’s request and expense. AstraZeneca shall not enter into any settlement of any claim described in this Section 4.8 that incurs any financial liability on the part of
SPINCO or requires an admission of liability, wrongdoing or fault on the part of SPINCO, without SPINCO’s prior written consent (such consent not to be unreasonably withheld, delayed, or conditioned). 

4.9.    Defense of Third Party Claims: If a claim is brought by a Third Party that a Supplied Product or use of a Supplied Product
infringes the Intellectual Property Rights of such Third Party, the Party receiving notice of such claim shall give prompt notice to the other Party of such claim, and following such notification, the Parties shall confer on how to respond. 

5.    Delivery 

5.1.    Time of Delivery: AstraZeneca shall undertake the Services in accordance with the applicable Product Schedule. The Project
Teams shall keep the timing of the delivery of the Services under review and, if applicable, propose updates to the applicable Product Schedule directly to SPINCO for its approval, which will not be unreasonably withheld or delayed, or to the JSC.
For clarity, if the terms of a Product Schedule require amendment, such amendment shall only take effect when the amendment is executed by both Parties. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 6.    Clinical Supply 

6.1.    Manufacture of Product for Clinical Trials: Article 7 (Inspection, Rejection and Acceptance of Supplied Products) and
Article 8 (Specifications; Change Control) shall apply to Supply Schedules for the supply of Existing Products (other than MEDI-551 and MEDI-1116) for use in clinical trials provided that the Parties
acknowledge and agree that such provisions may not be appropriate for initial cGMP batches and with respect to such batches AstraZeneca will not be able to guarantee manufacture in accordance with the Specifications or yield. The requirements for
such batches will be set out in the applicable Product Schedule and Article 7 will only apply to such batches as provided in the applicable Product Schedule. Sections 8.1 and 8.2 shall not apply to Development Service Schedules designed to develop,
modify or validate the manufacturing process or implement the specification for a Product. 
 6.2.    QAA: On or before execution
of the first Supply Schedule, the Parties will enter into a quality assurance agreement which shall include quality responsibilities with respect to, among other things, release testing, stability testing, access to IMP Dossier and record retention
requirements (the “QAA”). The Parties will update or enter into separate quality assurance agreements regarding the various Products, if required. 

7.    Inspection, Rejection and Acceptance of Supplied Product 

7.1.    Conforming Products: AstraZeneca shall manufacture, or have manufactured, the Products in accordance in all material
respects with the applicable Specification, the QAA, and any Applicable Laws and Regulations. 
 7.2.    Release: Product for use
in a clinical trial shall be released in accordance with the QAA. 
 7.3.    Shortfall or
Non-Conforming Product: SPINCO shall promptly notify AstraZeneca of any Shortfall or Non-Conforming Product in any delivery of Supplied Products. In such event,
SPINCO shall provide AstraZeneca with a detailed written report of the alleged Shortfall or Non-Conformance no later than: 
  

	 	7.3.1.	 [***] after SPINCO’s receipt of the applicable Supplied Product (or such different period of time that may
be set forth in the QAA with respect to a Non-Conformance), for any Shortfall or for any Non-Conformance that could be discovered within the applicable period by SPINCO
exercising reasonable diligence or its responsibilities under the QAA (“Apparent Defects”); or 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

	 	7.3.2.	 [***] after the Non-Conformance has become apparent, but in any event
no later than the actual date of expiry of the shelf-life of the Supplied Product in question (or such different period of time that may be set forth in the QAA), for any Non-Conformance which is not an
Apparent Defect (“Latent Defects”). 

 7.4.    Remedies for Shortfall or Non-Conformance: Subject to Section 7.6, provided SPINCO has duly notified AstraZeneca of a Shortfall or a Non-Conforming Product in accordance with Section 7.3,
AstraZeneca shall at SPINCO’s option either: 
  

	 	7.4.1.	 in the case of any Shortfall: 

 

	 	(a)	 make up the Shortfall as soon as reasonably practicable, at AstraZeneca’s cost and expense
(including if reasonably required express shipping costs); or 

  

	 	(b)	 refund to SPINCO the proportion of the Price paid by SPINCO which equates to the amount of the Shortfall
(including shipping costs), or, if the invoice has not been paid, cancel the invoice and issue a new invoice for the actual amount of the Supplied Product delivered; 

 

	 	7.4.2.	 in the case of any Non-Conforming Product: 

 

	 	(a)	 replace the Non-Conforming Product (or relevant portion of the Non-Conforming Product) as soon as reasonably practicable given the nature of the non-conformance, at AstraZeneca’s cost and expense (including if reasonably required
express shipping costs); 

  

	 	(b)	 refund to SPINCO the Price paid to AstraZeneca by SPINCO for the
Non-Conforming Product (including shipping costs), or, if the invoice has not been paid, cancel the invoice. 

7.5.    Return or Destruction of Non-Conforming Products: SPINCO may reject any Non-Conforming Product by providing notice of rejection to AstraZeneca, giving its reasons for rejection and reasonable evidence for the non-conformance. SPINCO shall, at
AstraZeneca’s option and expense (including shipping costs), return to AstraZeneca or destroy in an environmentally acceptable manner, in accordance with Applicable Laws and Regulations (and certify destruction of) any Non-Conforming Product. 
 7.6.    Disagreement: If a dispute arises between the Parties as to
whether or not a Supplied Product is a Non-Conforming Product, which cannot be resolved by the Parties within 

  
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[***] of a claim being notified by SPINCO to AstraZeneca, either Party may require that the matter in dispute be referred to an independent testing laboratory or other appropriate independent
expert mutually agreed upon by the Parties or, failing agreement, appointed by the ICC International Centre for Expertise at the request of either Party (the “Independent Expert”). 

7.7.    Referral to Independent Expert: The referral of any matter to the Independent Expert pursuant to Section 7.6 shall be
solely for the purpose of establishing whether or not there has been a supply of Non-Conforming Product. Except in the case of fraud or manifest error on the part of the Independent Expert, the decision of the
Independent Expert will be final and binding upon the Parties. If the Independent Expert decides that the relevant Product is a Non-Conforming Product, the costs of the Independent Expert will be borne by
AstraZeneca otherwise the costs of the Independent Expert will be borne by SPINCO. 
 7.8.    Recalls:  

7.8.1.    Recalls of Supplied Products will be governed by the QAA. 

7.8.2.    SPINCO shall be responsible for all costs and expenses of each recall (whether requested by SPINCO or
AstraZeneca), including costs and expenses incurred by AstraZeneca, except to the extent such recall results from the failure of AstraZeneca to deliver Supplied Product that complies with the applicable Specification, the QAA, or any Applicable Laws
and Regulations (including cGMP) at the time of delivery by AstraZeneca. AstraZeneca shall be responsible for all costs and expenses of each recall (whether requested by SPINCO or AstraZeneca), including costs and expenses incurred by SPINCO, and
AstraZeneca shall fully reimburse SPINCO the Price for each unit of recalled Supplied Product, to the extent such recall results from the failure of AstraZeneca to deliver Supplied Product that complies with the applicable Specifications, the QAA,
or any Applicable Laws and Regulations (including cGMP) at the time of delivery by AstraZeneca. 
 7.8.3.    If there is
any dispute concerning which Party’s acts or omissions gave rise to any recall of Supplied Product, such dispute shall be referred for decision to an Independent Expert. The decision of such Independent Expert shall be in writing and, except
for manifest error on the face of the decision, shall be binding on both SPINCO and AstraZeneca. The costs of such Independent Expert shall be borne by the Party that is found to be responsible for the recall by the Independent Expert. After such
determination, costs shall be paid by the responsible Party in accordance with Section 7.8.2. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 7.8.4.    SPINCO shall keep complete and accurate records of the
distribution of the Supplied Products, including methods for tracking and traceability as required under Applicable Laws and Regulations, to enable appropriate procedures to be implemented in the event that a voluntary or mandatory recall of any
Supplied Product is required and AstraZeneca shall have rights to audit such records. 
  

	8.	 Specifications; Change Control 

8.1.    AstraZeneca shall manufacture each Supplied Product for use in clinical trials in accordance with all Applicable Laws and
Regulations (including cGMP) and the Specification for such Supplied Product. Each Supplied Product provided by AstraZeneca pursuant to this Agreement shall conform to the Specification for such Supplied Product at the time of delivery by
AstraZeneca. 
 8.2.    Procedures governing changes to the Specification or changes in the manufacturing process, manufacturing
facility(is) or materials used by AstraZeneca to manufacture any Supplied Product (each a “Manufacturing Change”) will be set out in the QAA. Any Manufacturing Change shall be implemented in accordance with the provisions of the
QAA. 
 8.3.    If a Regulatory Authority requires any Manufacturing Change or AstraZeneca, acting in good faith, determines any
Manufacturing Change is otherwise required to comply with regulatory requirements (each a “Required Manufacturing Change”), the Parties shall, each acting reasonably and in good faith, endeavor to agree promptly an action plan in
relation to the implementation of such change; provided that if SPINCO, acting in good faith, disagrees with any AstraZeneca determination that a Manufacturing Change is required, AstraZeneca shall consider SPINCO’s comments in good faith. The
costs and expenses of implementing such change shall be borne solely by SPINCO; provided that, if and to the extent such Manufacturing Change is being made for the benefit of Supplied Products and other products that are manufactured by AstraZeneca
then SPINCO shall bear an equitable proportion of such costs and expenses. 
 8.4.    From time to time during the term of this
Agreement, SPINCO may request a Manufacturing Change other than a Required Manufacturing Change and AstraZeneca will consider any such requests in good faith. If AstraZeneca provides consent (such consent not

  
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to be unreasonably withheld, delayed, or conditioned), it will provide SPINCO with an estimate of the timeframe and costs and expenses for implementation of the change, including whether any such
costs and expenses (or a portion thereof) shall be reflected in the Price. If the Manufacturing Change is implemented, unless otherwise agreed, SPINCO shall bear the costs and expenses of the change. Where a Manufacturing Change is required by
SPINCO and such change results in rendering obsolete any inventory of Supplied Products or materials used in the manufacture of the Supplied Products, SPINCO shall bear the costs and expenses of such write-off
(including waste disposal costs) for Supplied Products and materials that AstraZeneca is not able to utilize elsewhere; provided that AstraZeneca will use commercially reasonable efforts to utilize such unused materials and SPINCO will provide
AstraZeneca with reasonable assistance in doing so. 
 8.5.    From time to time during the term of this Agreement, AstraZeneca may give
notice to SPINCO that AstraZeneca intends to implement a Manufacturing Change that is not a Required Manufacturing Change subject to Section 8.3 or a Facility Change subject to Section 8.6; provided that except as provided in this
Agreement or the QAA, AstraZeneca shall not implement a Manufacturing Change pursuant to this Section 8.5, unless SPINCO has given its consent to such change (such consent not to be unreasonably withheld, delayed or conditioned). If AstraZeneca
requests such a Manufacturing Change, unless otherwise agreed, AstraZeneca shall bear the costs and expenses of AstraZeneca implementing such change and the reasonable and verifiable costs (including with respect to the establishment of
comparability) incurred by SPINCO arising as a direct and unavoidable result of such change; provided that such costs shall not include any costs incurred by SPINCO with respect to supplementary regulatory filings. 

8.6.    From time to time during the term of this Agreement, AstraZeneca may give notice to SPINCO that AstraZeneca intends to change the
geographic location of the manufacturing site(s) used by AstraZeneca to manufacture a Supplied Product (a “Facility Change”). Unless otherwise agreed to by the Parties such notice must be provided to SPINCO at least two
(2) years prior to the anticipated Facility Change. Any Facility Change will be made in AstraZeneca’s sole discretion; provided that in implementing a Facility Change, AstraZeneca shall use its best efforts to minimize any adverse impact
on the IND or other Regulatory Approvals for the Product. AstraZeneca shall be responsible for the technology transfer and other costs and expenses of AstraZeneca implementing a Facility Change and the reasonable and verifiable costs (including with
respect to the establishment of comparability) 

  
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incurred by SPINCO arising as a direct and unavoidable result of such Facility Change in each case pursuant to this Section 8.6; provided that such costs shall not include any costs incurred
by SPINCO with respect to supplementary regulatory filings. 
  

	9.	 Representations, Warranties and Information 

9.1.    Representations and Warranties: AstraZeneca represents and warrants as at the Effective Date, and undertakes for the term of
this Agreement: 
 9.1.1.    the performance of its obligations to SPINCO under this Agreement will not breach or be in
conflict with any obligation to any Third Party, and will not infringe any rights of any Third Party; 
 9.1.2.    title
to the Supplied Products will pass to SPINCO under this Agreement free and clear of any security interest, lien, or other encumbrance; 

9.1.3.    all Personnel used in the performance of this Agreement will be competent to perform their respective functions
and fulfil their obligations in accordance with applicable standards; 
 9.1.4.    each Supplied Product provided by
AstraZeneca pursuant to this Agreement shall conform to the Specification, the QAA, and any Applicable Laws and Regulations for such Supplied Product at the time of delivery by AstraZeneca; 

9.1.5.    it shall comply with all regulations, statutes, and any Applicable Laws and Regulations in performance of this
Agreement; 
 9.1.6.    it is not debarred by any applicable Governmental Authority or Regulatory Authority as of the
Effective Date, and AstraZeneca has not, and shall not during the term of this Agreement, knowingly use in any capacity the services of any Person who has been debarred by any applicable authority with respect to its performance of this Agreement.
AstraZeneca will immediately notify SPINCO in the event that AstraZeneca becomes aware that it, its permitted subcontractors, or any of its or their employees engaged in the performance of the Services becomes debarred during the term of this
Agreement; 
 9.1.7.    it shall hold all licenses, permits and similar authorizations required by any Regulatory
Authority for it to perform its obligations under this Agreement; and 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 9.1.8.    it has not granted, and shall not grant during the term of
this Agreement, any right to any Third Party which would materially conflict with the rights granted to SPINCO hereunder. It has, and covenants that it shall, maintain and keep in full force and effect all agreements necessary to perform its
obligations in this Agreement. 
  

	10.	 Payment 

10.1.    Prices: The Prices for Product batches, Supplied Product and other Services will be as stated in the applicable Product Schedule;
provided that, where services are to be charged on a time basis, unless otherwise agreed, fees payable for such services shall be based on the FTE Rate. AstraZeneca shall also be reimbursed for its Out-of-Pocket Costs. For the purpose of this Agreement, unless otherwise agreed in a Product Schedule, the initial FTE Rate shall be an annual rate of [***] for the time of an employee for a full-time
equivalent (“FTE”) person year [***] of work, pro-rated on a daily basis. [***]. 

10.2.    Invoices: AstraZeneca shall issue an invoice to SPINCO for the Price in accordance with the relevant Product Schedule.
Each invoice shall contain a reference to the relevant Product Schedule and if applicable Purchase Order number, and shall comply with Applicable Laws and Regulations regarding information required on a valid invoice.  

10.3.    Payment Period: Unless otherwise stated in the applicable Product Schedule, SPINCO shall pay all invoices within [***]
after SPINCO’s receipt of the invoice. The amounts payable by SPINCO to AstraZeneca pursuant to this Agreement (“Payments”) shall not be reduced on account of any Taxes unless required by Applicable Laws and Regulations.
AstraZeneca alone shall be responsible for paying any and all Taxes (other than withholding Taxes required to be paid by SPINCO) levied on account of, or measured in whole or in part by reference to, any Payments it receives. SPINCO shall deduct or
withhold from the Payments any Taxes that it is required by Applicable Laws and Regulations to deduct or withhold. To the extent that any such Tax is deducted or withheld, such amount shall be treated for all purposes of the Agreement as having been
paid to the Person in respect of which such deduction or withholding was made. Notwithstanding the foregoing, if AstraZeneca is entitled under any applicable Tax treaty to a reduction of rate of, or the elimination of, or recovery of, applicable
withholding Tax, it shall deliver to SPINCO or the appropriate Governmental Authority (with the assistance of SPINCO to the extent that this is reasonably required and is expressly requested in writing) the prescribed forms necessary to reduce the
applicable rate of 

  
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withholding or to relieve SPINCO of its obligation to withhold Tax, and SPINCO shall apply the reduced rate of withholding, or dispense with the withholding, as the case may be, to the extent it
complies with the applicable Tax treaty. If, in accordance with the foregoing, SPINCO withholds any amount, it shall make timely payment to the proper Governmental Authority of the withheld amount, and send to AstraZeneca proof of such payment
within 60 days following that payment. All Payments are stated exclusive of Indirect Taxes. If any Indirect Taxes are chargeable in respect of any Payments, SPINCO shall pay such Indirect Taxes at the applicable rate in respect of any such Payments
following the receipt, where applicable, of an Indirect Taxes invoice in the appropriate form issued by AstraZeneca in respect of such Payments, such Indirect Taxes to be payable on the due date of the payment of the Payments to which such Indirect
Taxes relate. AstraZeneca shall issue its invoices for all amounts payable under this Agreement consistent with Indirect Tax requirements and irrespective of whether the sums may be netted for settlement purposes. 

10.4.    Failure to Timely Pay: If a Party fails to pay any amount payable under this Agreement by the due date for payment, then:

 10.4.1.    interest shall accrue on that amount for the period beginning on the due date for payment and ending on the
date of actual payment (both before and after judgment) at the rate of [***]. Interest shall be calculated on the basis of a year of 365 days and for the actual number of days elapsed, shall accrue from day to day, and shall be compounded quarterly;
and 
 10.4.2.    if amounts are payable by SPINCO, without prejudice to Section 10.4.1 and subject to giving SPINCO
[***] prior written notice of its intention to do so, AstraZeneca shall be entitled to suspend any of its obligations under this Agreement until such time as any unpaid amounts have been paid in full. 

10.5.    No Set Off: Except with respect to an obligation owed by AstraZeneca under this Agreement that has been finally
adjudicated, settled or otherwise agreed upon by the Parties in writing, SPINCO shall not have any right of set-off (howsoever arising) in respect of any sums payable in connection with this Agreement and all
sums payable by SPINCO to AstraZeneca under this Agreement shall be paid in full without set-off, counterclaim or other deduction. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 10.6.    Audits; Disputes; Requests for Information: The Parties shall reasonably
work together with respect to audits, disputes or requests for information with respect to Taxes (e.g., provision of relevant information and documents) in connection with this Agreement, including making use of the audit process required by Article
23 (Records, Monitoring and Right to Audit). 
  

	11.	 Confidentiality 

11.1.    Confidentiality: At all times during the term of this Agreement and for a period of [***] following expiry or termination
of this Agreement or if later, expiry or termination of the last Product Schedule, each Party shall and shall cause its Personnel to keep confidential and not publish or otherwise disclose to a Third Party and not use, directly or indirectly, for
any purpose, any Confidential Information furnished or otherwise made known to it, directly or indirectly, by the other Party, except to the extent such disclosure or use is expressly permitted by the terms of this Agreement; provided that with
respect to any Manufacturing Technology, the foregoing confidentiality obligation shall survive indefinitely. Notwithstanding the foregoing, the confidentiality and non-use obligations under this
Section 11.1 with respect to any Confidential Information shall not include any information that: 
 11.1.1.    is
or hereafter becomes part of the public domain by public use, publication, general knowledge or the like through no breach of this Agreement by the receiving Party (or its Affiliates or permitted Representatives); 

11.1.2.    can be demonstrated by documentation or other competent proof to have been in the receiving Party’s (or its
Affiliates’) possession prior to disclosure by the disclosing Party without any obligation of confidentiality with respect to such information; 

11.1.3.    is subsequently received by the receiving Party from a Third Party who is not bound by any obligation of
confidentiality with respect to such information; 
 11.1.4.    has been published by a Third Party or otherwise enters
the public domain through no fault of the receiving Party in breach of this Agreement; or 
 11.1.5.    can be
demonstrated by documentation or other competent evidence to have been independently developed by or for the receiving Party without reference to the disclosing Party’s Confidential Information. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 Specific aspects or details of Confidential Information shall not be deemed to be within the public domain
or in the possession of the receiving Party merely because the Confidential Information is embraced by more general information in the public domain or in the possession of the receiving Party. Further, any combination of Confidential Information
shall not be considered in the public domain or in the possession of the receiving Party merely because individual elements of such Confidential Information are in the public domain or in the possession of the receiving Party unless the combination
and its principles are in the public domain or in the possession of the receiving Party. For clarity, (a) except to the extent assigned to SPINCO pursuant to the APA, Confidential Information of AstraZeneca or its Affiliates known to employees
of SPINCO prior to the Effective Date shall remain AstraZeneca’s Confidential Information and shall be deemed to have been disclosed to SPINCO subject to obligations of confidentiality; (b) even if known to any such employee, SPINCO shall
not use or disclose any MedImmune Manufacturing Technology except as expressly provided in Section 4.7. 
 11.2.    Permitted
Disclosure: Notwithstanding Section 11.1, but in each case (11.2.1 through 11.2.4) subject to Sections 4.6, 4.7 and 15.7: 

11.2.1.    each Party may disclose all or any part of the other Party’s Confidential Information to its Affiliates,
and to its and its Affiliates’ respective Personnel, financial and legal advisors, investors and suppliers (“Representatives”); provided, however, that such Party ensures that such Representatives comply mutatis mutandis
with the obligations imposed on such Party under this Article 11 (Confidentiality) and such Party shall be liable for any breach of such obligations by its Representatives. Each Party will disclose Confidential Information received from the
other Party only to those of its Representatives who have a need to know such Confidential Information for the purpose of carrying out its obligations and exercising its rights under this Agreement, or with respect to disclosures to financial
advisors and investors, as provided in Section 11.2.2, and in any case only to the extent required for the permitted purpose. For example, disclosure of expenses on a profit and loss basis would not require disclosure of the actual Price, or
disclosure of the calculation of such Price including any details relating AstraZeneca’s costs of manufacturing or providing the Services; 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 11.2.2.    SPINCO may disclose AstraZeneca’s Confidential
Information to financial advisors and investors for the purpose of raising finance for SPINCO (e.g. for clinical trials) provided that AstraZeneca has given its prior written consent to the form and content of such proposed disclosure (such consent
not to be unreasonably withheld, delayed or conditioned). Following approval of such disclosure document by AstraZeneca, subject to Section 11.2.1, SPINCO may disclose the information contained in such document to financial advisors, investors
and potential investors for such purpose without the need for further approval by AstraZeneca; 
 11.2.3.    each Party
may disclose the other Party’s Confidential Information to the extent that such disclosure is (i) required to be made in response to a valid order of a court or Governmental Authority of competent jurisdiction or (ii) is otherwise
required by Applicable Laws and Regulations; provided that the Party requested or required to disclose such Confidential Information shall first promptly notify the other Party in writing in a timely manner so that such other Party may seek a
protective order or other appropriate remedy or, in such other Party’s sole discretion, waive compliance with the confidentiality provisions of this Agreement as to their own Confidential Information. Each Party will cooperate in all reasonable
respects in connection with any reasonable actions to be taken for the foregoing purpose. In any event, the Party requested or required to disclose such Confidential Information may furnish it as required by such valid court order or Regulatory
Authority, or Applicable Laws and Regulations (subject to any such protective order or other appropriate remedy) without liability hereunder; provided, that such Party furnishes only that portion of the Confidential Information which such Party is
advised by an opinion of its counsel is legally required, and such Party exercises reasonable efforts to obtain reliable assurances that confidential treatment will be accorded such Confidential Information; 

11.2.4.    each Party may disclose the other Party’s Confidential Information to any Regulatory Authority to the
extent necessary to obtain or maintain the approval of any such Regulatory Authority to manufacture and supply any Supplied Product or perform any other Services pursuant to the terms and conditions of this Agreement; provided, however, that
reasonable measures shall be taken to assure confidential treatment of such Confidential Information; and 

11.2.5.    for clarity, MedImmune Manufacturing Technology will only be disclosed to SPINCO in accordance with
Section 4.7 and, notwithstanding this Section 11.2, shall only be used and disclosed by SPINCO as expressly permitted by Section 4.7. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 11.3.    Press Releases; Public Announcements: Except as provided in the APA,
SPINCO and AstraZeneca agree not to issue any press releases or public announcements concerning this Agreement (and to ensure that their respective Affiliates do not do so) without the prior written consent of the other Party to the form, timing and
content of any such release or announcement, except as required by Applicable Laws and Regulations, including disclosure required by any securities exchange. 

11.4.    Injunctive Relief: Each Party acknowledges that damages resulting from disclosure of Confidential Information not
permitted hereby may be an insufficient remedy and that in the event of any such disclosure or any indication of an intent to disclose such information, the other Party shall be entitled to seek, by way of private litigation, injunctive relief or
other equitable relief in addition to any and all remedies available at law or in equity. 
 11.5.    Return or Destruction of
Confidential Information: Subject to Section 11.6, on expiry or termination of this Agreement or at any time at the disclosing Party’s request, the receiving Party shall return to the disclosing Party all copies containing Confidential
Information of the disclosing Party or, at the disclosing Party’s option, destroy all copies of such Confidential Information. The return or destruction of the Confidential Information of the disclosing Party will not affect the receiving
Party’s obligation to observe the confidentiality and non-use restrictions in respect of that Confidential Information set out in this Agreement. 

11.6.    Permitted Retention of Confidential Information: Each Party may keep one (1) copy of Confidential Information for
evidence purposes at a secure place subject to the confidentiality and non-use obligations provided in this Article 11 (Confidentiality). The aforementioned return and destruction obligation shall not
apply to electronic copies of Confidential Information which are rightfully contained in computers, word processors, communication systems and system-backup media (collectively “IT Media”) which do not need to be destroyed or
returned, provided that such IT Media are: (a) overwritten in the ordinary course of their reuse; or (b) at all times maintained in confidence and not readily accessible and the receiving Party shall treat such copies as confidential in
accordance with this Article 11 (Confidentiality). 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

	12.	 Liability 

12.1.    Disclaimer: Except to the extent set out expressly in this Agreement, all conditions, warranties or other terms which might
have effect between the Parties or be implied or incorporated into this Agreement (whether by statute, common law or otherwise) are hereby excluded to the fullest extent permitted by Applicable Laws and Regulations. Without prejudice to the general
nature of the previous sentence, unless this Agreement specifically states otherwise, AstraZeneca does not make any representations or warranties pursuant to this Agreement (a) with respect to any Supplied Product, including any representations
or warranties as to non-infringement or fitness for a particular purpose or (b) as to the results of any Development Services. 

12.2.    Limitation of Liability: TO THE EXTENT PERMITTED BY LAW, NOTWITHSTANDING ANY OTHER PROVISION CONTAINED HEREIN, UNLESS
RESULTING FROM A PARTY’S WILLFUL MISCONDUCT, GROSS NEGLIGENCE, OR FRAUD, IN NO EVENT SHALL ASTRAZENECA, ON THE ONE HAND, OR SPINCO, ON THE OTHER HAND, BE LIABLE TO THE OTHER OR ANY OF THE OTHER’S AFFILIATES FOR ANY CONSEQUENTIAL,
INCIDENTAL, INDIRECT, SPECIAL, PUNITIVE OR EXEMPLARY DAMAGES (INCLUDING, LOST PROFITS, BUSINESS OR GOODWILL) SUFFERED OR INCURRED BY SUCH OTHER PARTY OR ITS AFFILIATES IN CONNECTION WITH A BREACH OR ALLEGED BREACH OF THIS AGREEMENT. 

12.3.    Maximum Liability: THE AGGREGATE LIABILITY OF ASTRAZENECA UNDER OR IN CONNECTION WITH ANY PRODUCT SCHEDULE SHALL NOT
EXCEED [***] PROVIDED THAT SUCH LIMITATION SHALL NOT APPLY TO ASTRAZENECA’S OBLIGATION TO INDEMNIFY SPINCO PURSUANT TO ARTICLE 13 (Indemnities) TO THE EXTENT SUCH THIRD PARTY CLAIM RESULTS FROM ASTRAZENECA’S GROSS NEGLIGENCE OR WILLFUL
MISCONDUCT. 
 12.4.    Recovery of Damages: Neither Party shall be entitled under any provision of this Agreement to recover
damages, or obtain payment, reimbursement, restitution or indemnity more than once in respect of the same loss, shortfall, damage, deficiency, breach or other event or circumstance. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

	13.	 Indemnities 

13.1.    Indemnification of AstraZeneca: SPINCO shall indemnify and hold AstraZeneca and its Affiliates harmless from and against
any and all Losses arising from any claims from Third Parties (each a “Third Party Claim”) based on or deriving from AstraZeneca or its Affiliates’ providing any Services, including the manufacture or supply of any Supplied
Product to, SPINCO or performing any other activities pursuant to this Agreement, except to the extent that any such Third Party Claim or Losses result from a breach of this Agreement (including a breach of any representation or warranty), gross
negligence, or willful misconduct by AstraZeneca or any of its Affiliates or any of their respective Personnel. 

13.2.    Indemnification of SPINCO: Subject to Section 13.3, AstraZeneca shall indemnify and hold SPINCO and its Affiliates
harmless from and against all Losses arising from Third Party Claims involving actual or alleged death or personal injury arising out of any defect or fault in, manufacture of, or materials used in (other than materials provided by SPINCO), the
Supplied Products to the extent that such Losses result from a breach of this Agreement (including a breach of any representation or warranty), gross negligence, or willful misconduct by AstraZeneca or any of its Affiliates or any of their
respective Personnel. 
 13.3.    Exceptions and Limitations on Indemnification: AstraZeneca shall not be liable under the
indemnity in Section 13.2 where the liability arises as a result of: 
 13.3.1.    the supply by SPINCO, its
Affiliates or their respective Personnel or licensees of any Supplied Product which has Apparent Defects, or whose shelf-life has expired; or 

13.3.2.    any defect or fault in any Supplied Product which is caused by any act or omission of SPINCO, its Affiliates or
by their respective Personnel or licensees, or by any damage or event occurring whilst any Supplied Product is in the possession or control of SPINCO, its Affiliates or their respective Personnel or licensees. 

13.4.    Indemnification Procedures: As soon as either Party (the “Indemnitee”) becomes aware of any matter which
may result in making a claim under the indemnity against the other Party (the “Indemnifying Party”) in Section 13.1 or Section 13.2, the Indemnitee shall: 

13.4.1.    give the Indemnifying Party notice of such matter as soon as reasonably practicable on becoming aware of
it; 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 13.4.2.    not at any time admit liability or otherwise settle or
compromise, or attempt to settle or compromise, the matter (or any aspect of it) except on the Indemnifying Party’s express written instructions; 

13.4.3.    give the Indemnifying Party sole conduct of the defense, negotiation or settlement of any such matter upon
request; 
 13.4.4.    act in accordance with the Indemnifying Party’s reasonable instructions, and give the
Indemnifying Party such assistance as it may reasonably require in the conduct of any such defense, negotiation or settlement; and 

13.4.5.    take all reasonable steps to mitigate any Losses which it may incur as a result of such matter. 

 

	14.	 Insurance 

14.1.    Insurance: Each Party shall, and shall ensure that their respective Affiliates shall, take out and maintain such types and
amounts of liability insurance or, in the case of AstraZeneca, self-insurance to cover liabilities related to its activities under this Agreement as is normal and customary in the pharmaceutical industry generally for Persons similarly situated, and
shall upon request provide to the other Party evidence of such insurance coverage. Such insurance coverage shall remain in effect throughout the term of this Agreement and for a period of [***] thereafter. 

 

	15.	 Term and Termination 

15.1.    No Product Schedules: If there are no Product Schedules in force for a continuous period of at least twelve
(12) months, either Party may immediately terminate this Agreement on written notice to the other Party. 
 15.2.    Term of
Product Schedule: Each Product Schedule shall remain in force for its Term, unless terminated earlier under this Article 15. 

15.3.    Product Schedule Termination on Notice: A Product Schedule may also be terminated on notice without cause or in other
circumstances, if so provided in the Product Schedule, or by mutual agreement of the Parties. 
 15.4.    For Convenience: SPINCO
may terminate this Agreement at any time during the term of this Agreement upon at least six (6) months’ prior written notice to AstraZeneca. For clarity, such termination shall not terminate any Product Schedule then in force. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 15.5.    Material Breach: This Agreement or a Product Schedule may be immediately
terminated by a Party on written notice if the other Party commits a material breach of this Agreement or that Product Schedule, and that breach: 

15.5.1.    is reasonably determined by the non-breaching Party to not be capable of
cure; or 
 15.5.2.    is capable of cure but remains uncured sixty (60) days after written notice of such breach.

 15.6.    Insolvency Events: This Agreement and all Product Schedules may be immediately terminated by a Party on written
notice if the other Party suffers an Insolvency Event. 
 15.7.    Technology Transfer: If SPINCO terminates a Product Schedule
because AstraZeneca is in material breach of its obligations to supply Product for use in clinical trials, AstraZeneca suffers an Insolvency Event or SPINCO terminates this Agreement in accordance with Section 15.8, at SPINCO’s request,
AstraZeneca and SPINCO shall cooperate in good faith to agree upon the terms and conditions of a written technology transfer plan pursuant to which AstraZeneca and SPINCO shall use reasonable efforts to carry out a reasonable technology transfer to
enable SPINCO or a Third Party contract manufacturer to manufacture the Products. Such plan may involve continuation of existing Product Schedules designed to effect a technology transfer with respect to such Product or a new technology transfer
plan as may be agreed by the Parties. AstraZeneca shall reasonably cooperate and promptly perform any agreed technical transfer and validation activities reasonably necessary to enable SPINCO or such Third Party contract manufacturer to supply the
applicable Product. If the technology transfer involves the transfer of any MedImmune Manufacturing Technology such transfer shall be to a mutually agreed Third Party contract manufacturer and shall be subject to the same terms as applicable to a
technology transfer relating to MEDI-551 as set out in Clause 20.2 of the CSA. 

15.8.    Force Majeure: SPINCO may terminate this Agreement on prior written notice to AstraZeneca, within [***] of being provided
with the Remediation Plan (as defined below), if implementation of the Remediation Plan (as amended to include SPINCO’s comments) will not enable AstraZeneca to resume delivery of the Supplied Product to SPINCO within [***] of the commencement
of the Force Majeure event. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 15.9.    Survival of Rights and Obligations: The expiration or termination of
this Agreement or a Product Schedule shall be without prejudice to any rights or obligations that may have accrued prior to such expiration or termination, and shall not affect any provision which is expressly or by implication intended to come into
or continue in force on or after expiration or termination. 
  

	16.	 Force Majeure 

16.1.    Force Majeure: If a Party is prevented from or delayed in performing any of its obligations under the Agreement by a Force
Majeure event then: 
 16.1.1.    the relevant obligations under this Agreement shall be suspended for as long as the
Force Majeure event continues and the Party shall not be in breach of this Agreement or otherwise liable for any such failure or delay in the performance of such obligations during such event; 

16.1.2.     as soon as reasonably practicable after the start of the Force Majeure event, the Party shall notify the other
of the nature of the Force Majeure event and the likely effects of the Force Majeure event on its ability to perform its obligations under this Agreement; and 

16.1.3.    as soon as reasonably practicable after the end of the Force Majeure event it shall notify the other Party that
the Force Majeure event has ended, and shall resume performance of its obligations under this Agreement. 
 16.2.    If there is a Force
Majeure event that AstraZeneca reasonably expects will prevent it from delivering at least [***] of Purchase Orders for more than [***] [***], AstraZeneca shall prepare and present to SPINCO for discussion a summary remediation plan intended to
address the supply situation as soon as commercially reasonable (the “Remediation Plan”) and AstraZeneca shall consider in good faith SPINCO’s comments and suggestions. AstraZeneca shall use commercially reasonable efforts to
implement the Remediation Plan and shall provide SPINCO updates on a monthly basis on the implementation and corrective effect of the Remediation Plan. 
  

	17.	 Assignment, Transfer and Subcontracting 

17.1.    Assignment: No Party may assign or transfer this Agreement or any rights or obligations hereunder, directly or indirectly
(by operation of law or otherwise), without the prior written approval of the other Party and any attempted assignment without such required 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 
approval shall be null, void and of no effect; provided, however, that (a) AstraZeneca may assign or delegate any or all or its rights, interests or obligations hereunder to an Affiliate of
AstraZeneca or to any successor in interest (whether by merger, acquisition, asset purchase or otherwise) to all or substantially all of the business to which this Agreement relates, and may delegate any or all of its obligations hereunder to
subcontractors, in each case, without SPINCO’s prior written approval, and (b) SPINCO may assign its rights, interests, and obligations hereunder (in whole and not in part) to a wholly owned Affiliate of SPINCO without AstraZeneca’s
prior written approval. In addition, following the earlier to occur of (c) the consummation in full of the Milestone Closing (as defined in the Securities Purchase Agreement), and (d) the consummation of a Qualified IPO (as defined in the
Restated Certificate (as defined in the Securities Purchase Agreement)), SPINCO may assign its applicable rights, interests, and obligations hereunder related to one or more Programs to a Third Party without AstraZeneca’s prior written
approval, so long as (i) such assignment shall be in connection with the divestment by SPINCO of all or substantially all of the assets relating to such Program or Programs (whether by asset purchase or exclusive
out-license), (ii) in connection therewith, SPINCO also assigns to such Third Party its applicable rights, interests, and obligations under the other Transaction Agreements related to such Program or Programs,
and (iii) proper provision shall be made so that the successors and assigns of SPINCO shall succeed to SPINCO’s applicable rights and obligations set forth herein and therein. Furthermore, if SPINCO or any of its successors or assigns
(e) consolidates with or merges into any other Person and shall not be the continuing or surviving corporation or entity of such consolidation or merger or (f) transfers, licenses or conveys all or substantially all of its rights and
assets to any Person, then, and in each such case, SPINCO may assign its rights, interests and obligations hereunder (in whole and not in part) to such Person without the prior written approval of AstraZeneca so long as in connection therewith
SPINCO (i) also assigns to such Person all of its applicable rights, interests, and obligations under the other Transaction Agreements, and (ii) ensures that proper provision shall be made so that the successors and assigns of SPINCO shall
succeed to SPINCO’s rights and obligations set forth in this Agreement. Notwithstanding anything to the contrary set forth herein, no assignment or succession pursuant to this Clause 17.1 shall relieve the assigning Party or predecessor Party
of its obligations hereunder. Upon any permitted assignment, the references in this Agreement to a Party shall also apply to any such assignee unless the context otherwise requires. Notwithstanding the foregoing, in the event a Party assigns its
rights or obligations under this Agreement or otherwise makes payments from a jurisdiction other than the jurisdiction in 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 
which such Party is organized (each, an “Assignment”), and immediately after such Assignment the amount of Tax required to be withheld on any payment pursuant to this Agreement
is greater than the amount of such Tax that would have been required to have been withheld absent such Assignment, then such increased withholding tax shall be borne by the Party making such Assignment. 

17.2.    Subcontracting: AstraZeneca shall be entitled to subcontract its obligations under this Agreement to any Affiliate and to
Third Parties; provided that, unless provided for in the applicable Product Schedule or where the Third Party provides similar services to AstraZeneca or its Affiliates in relation to other products, subcontracting to a Third Party shall require the
prior written consent of SPINCO (such consent not to be unreasonably withheld). Subcontracting shall not relieve AstraZeneca from any liability or obligation under this Agreement and AstraZeneca shall be responsible for the acts or omissions of its
subcontractors as fully as if they were its own. AstraZeneca shall ensure that any subcontractor complies with all relevant provisions of this Agreement. 
  

	18.	 Notices 

18.1.    Form of Notice: Any notice permitted or required under this Agreement shall be in writing and shall be deemed given only if
delivered by hand or sent by email, facsimile, or internationally recognized overnight delivery service that maintains records of delivery, addressed to a Party at the addresses specified below, or specified in the relevant Product Schedule, or to
such other addresses of which notice shall have been given in accordance with this Section. Notice shall be deemed to have been given as of the date delivered by hand or on the third delivery day after deposit with an internationally recognized
overnight delivery service. This Section 18.1 is not intended to govern the day-to-day business communications necessary between the Parties in performing their
obligations under the terms of this Agreement. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 18.2.    Address for Notice: 

 

					
	AstraZeneca	  	 [***]
  

[***]
 [***]

[***]
 [***]

[***]
 [***]

[***]
 [***]
	  	 [***]
  

[***]
 [***]

[***]
 [***]

[***]
 [***]

			
	SPINCO	  	 [***]
  

[***]
 [***]

[***]
 [***]

[***]
	  	 [***]
  

[***]
 [***]

[***]
 [***]

[***]
 [***]

[***]

  

	19.	 General 

19.1.    Relationship of Parties: The status of a Party under this Agreement shall be that of an independent contractor and nothing
in this Agreement authorizes or permits a Party to act as agent of, or to otherwise make representations or commitments on behalf of, the other Party. 

19.2.    Waivers: No failure or delay by any Party in enforcing any provision of this Agreement shall be deemed a waiver of that
Party’s rights to later enforce that provision or any other provision of this Agreement. To be effective any waiver must be in writing and signed by the waiving Party. No single or partial exercise of any right or remedy provided under this
Agreement shall prevent or restrict the further exercise of that or any other right or remedy. 
 19.3.    Severability: If any
provision or part-provision of this Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant
provision or part-provision shall be deleted. Any modification to or deletion of a provision or part-provision shall not affect the validity and enforceability of the rest of this Agreement. 

19.4.    Entire Agreement: This Agreement, the Product Schedules, the QAA, the CSA, the APA and any agreement entered into in
connection with the APA, constitute the entire agreement between the Parties, and supersedes all prior agreements, arrangements and understandings between them, whether written or oral, with respect to their subject matter. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 19.5.    No Reliance: Each Party confirms that it is not relying on any
statement, assurance, warranty or representation (whether made innocently or negligently) of the other Party except as specifically set out in this Agreement. This Section 19.5 is not intended to limit or exclude liability for fraud or
fraudulent misrepresentation. 
 19.6.    Amendments and Modifications: Any amendment or modification of this initial Agreement
must be in writing and signed by authorized representatives of both Parties. Any such amendment or modification to this initial Agreement shall, unless otherwise agreed by the Parties, automatically be made to each Agreement formed by the entry into
a Product Schedule between the same entities, whether or not that Product Schedule was entered into before or after the date of the amendment or modification, but shall only apply to Affiliate Product Schedules if those Affiliate Product Schedules
are entered into after the date of amendment or modification of the initial Agreement. Each Agreement formed by the entry into a Product Schedule or an Affiliate Product Schedule may only be amended or modified by way of the authorized
representative of the relevant entities signing an amendment or modification to the relevant Product Schedule or Affiliate Product Schedule and such amendment or modification shall not impact any other Product Schedule or Affiliate Product Schedule.

 19.7.    Third Parties: The provisions of this Agreement are for the sole benefit of the Parties and their successors and
permitted assigns, and they shall not be construed as conferring any rights in any other persons except as otherwise provided in this Agreement. No one other than a Party to this Agreement, their successors and permitted assigns, has any right to
enforce any of its terms. 
 19.8.    Counterparts: This Agreement may be executed in two counterparts, each of which will be
deemed an original and all of which will together be deemed to constitute one agreement. The Parties agree that the execution of this Agreement by industry standard electronic signature software and/or by exchanging PDF signatures shall have the
same legal force and effect as the exchange of original signatures, and that in any proceeding arising under or relating to this Agreement, each Party hereby waives any right to raise any defense or waiver based upon execution of this Agreement by
means of such electronic signatures or maintenance of the executed agreement electronically. 
 19.9.    Jurisdiction and Dispute
Resolution: The terms of this Section 19.9 shall apply with respect to any dispute arising out of or relating to this Agreement other than disputes that may be determined by the Independent Expert under Sections 7.6 and 7.7 or 7.8.3: 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 19.9.1.    The Parties agree to unconditionally and irrevocably submit
to the exclusive jurisdiction of the United States District Court for the Southern District of New York sitting in New York County or, if such court does not have subject matter jurisdiction, then the Commercial Division, Civil Branch of the Supreme
Court of the State of New York sitting in New York County and any appellate court from any thereof, for the resolution of any such claim or dispute. 

19.9.2.    The Parties hereby irrevocably waive, to the fullest extent permitted by Applicable Laws and Regulations, any
objection which they may now or hereafter have to the laying of venue of any such dispute brought in such court or any defense of inconvenient forum for the maintenance of such dispute. Each of the Parties agrees that a judgment in any such dispute
may be enforced in other jurisdictions by suit on the judgment or in any other manner provided by Applicable Laws and Regulations. 

19.9.3.    Each of the Parties hereby consents to process being served by any Party in any suit, action or proceeding by
delivery of a copy thereof in accordance with the provisions of Article 18 (Notices). 
 19.10.    Governing Law: This
Agreement shall be governed by and construed in accordance with the laws of the State of New York, excluding any conflicts or choice of law rule or principle that might otherwise refer construction or interpretation of this Agreement to the
substantive law of another jurisdiction. 
 19.11.    Equitable Relief: A breach by either Party of the confidentiality and non-use obligations in Article 11 (Confidentiality) and in the case of SPINCO, Sections 4.6 and 4.7, will cause irreparable damage and the non-breaching Party will not
be adequately compensated by monetary damages. In the event of a breach, or threatened breach, of those obligations, the non-breaching Party shall be entitled to obtain from any court of competent jurisdiction
equitable relief, whether preliminary or permanent, without the need to show irreparable harm or the inadequacy of monetary damages as a remedy and without the requirement of having to post a bond or other security. Nothing in this
Section 19.11 is intended, or shall be construed, to limit the Parties’ rights to equitable relief or any other remedy for a breach of any provision of this Agreement. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 PART B: WAYS OF WORKING 
  

	20.	 Oversight 

20.1    Project Teams: As soon as reasonably practicable after execution of any Product Schedule, each Party shall appoint
not less than one representative to form a Product team to support the Development Activities to be performed under such Product Schedule (each a “Project Team”). The Parties shall use reasonable endeavors to ensure that the members
of each Project Team cooperate with each other to ensure that the objectives of the Product Schedule are achieved. 

20.2    Joint Development Committee: Promptly following the Effective Date, the Parties shall form a joint development
committee (the “JDC”) to oversee and co-ordinate the execution and performance of the Development Activities. In particular, the JDC shall: 

 

	(a)	 [***] 

  

	(b)	 [***]; 

  

	(c)	 [***]; 

  

	(d)	 [***] 

  

	(e)	 [***]. 

The JDC shall meet once per calendar quarter or more frequently as agreed by the Parties. The JDC shall operate by consensus. If the JDC cannot
agree on a matter relating to the Development Activities [***] after it has met and attempted to reach such consensus, then either Party may, by written notice to the other, have such issue referred to the JSC for further discussion. 

20.3    Joint Steering Committee: Promptly following the Effective Date, the Parties shall establish a joint steering
committee (the “JSC”), to provide strategic oversight in connection with the Development Activities. The JSC shall meet once per calendar year or more frequently as required to approve any Product Schedules and resolve any issues
referred to the JSC by the JDC. The JSC shall seek to resolve any issues relating to the Development Activities by consensus but shall not have authority to bind either Party or amend this Agreement. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 20.4    Procedural Matters: The JDC and JSC shall consist of one
representative from each of the Parties, or such other number of representatives as the Parties may agree in writing from time to time. The AstraZeneca representatives on the JSC and the JDC shall be appointed by the head of MedImmune
Biopharmaceutical Development. The applicable representatives of each Party will co-chair the JDC and the JSC. Each committee shall adopt such standing rules as its members may agree to ensure that it operates
efficiently. 
 21.    Compliance 

21.1.    Authorization: AstraZeneca shall at all times during the term of this Agreement be appropriately authorized under
Applicable Laws and Regulations to perform its obligations. 
  

	22.	 Safety, Health and Environment 

22.1.    Health, Safety and Security Rules: If any Development Activities requires a representative from a Party to attend the site
of the other Party, the first Party shall ensure that it and its employees are aware of and comply with appropriate health, safety and security rules at the relevant site. 

22.2.    Hazards: AstraZeneca shall ensure that procedures are in place to assess and manage hazards in the workplace. 

22.3.    Registrations and Approvals: AstraZeneca shall ensure that all registrations and approvals for their associated activities
are in place as required for local and international regulations. 
  

	23.	 Records, Monitoring and Right to Audit 

23.1.    Records: For purposes of this Agreement, “Records” will mean information created, received or recorded in
any format by AstraZeneca in the performance of AstraZeneca’s obligations under this Agreement. AstraZeneca will maintain and retain complete organized and accurate Records of all equipment and sites used and services provided, including
records of raw materials, manufacture, testing, storage and delivery of Supplied Products. AstraZeneca will ensure that Records are protected from destruction or damage and are maintained within AstraZeneca’s control during the term of this
Agreement for six (6) years thereafter, or for a longer period of time as requested by SPINCO and agreed to by AstraZeneca, or as otherwise specified in this Agreement. SPINCO or its authorized representatives, will on reasonable notice be
permitted to examine and obtain copies of such Records at SPINCO’s expense. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 23.2.    Audit: For the term of this Agreement and six (6) years thereafter
AstraZeneca shall for the purpose of auditing and monitoring its performance of this Agreement grant to SPINCO and its auditors and any Regulatory Authority the right of access to any premises of AstraZeneca or its Affiliates, together with a right
to access Personnel, systems, processes and records (including financial records) that relate directly to the activities undertaken pursuant to this Agreement. Audits shall normally be undertaken once a year for each audit type, two audits may be
conducted where an audit is undertaken as a result of an alleged material breach of this Agreement or a re-audit is required. Audits shall be conducted with reasonable notice to AstraZeneca and during business
hours and shall not exceed [***] in duration. To the extent that any audit under this Section 23.2 or any other provision of this Agreement by SPINCO requires access and review of any commercially or strategically sensitive information relating
to the business of AstraZeneca or its Affiliates, such activity shall be carried out by non-Affiliate Third Party professional advisors appointed by SPINCO with AstraZeneca’s consent (such consent not to
be unreasonably withheld, conditioned, or delayed), and such professional advisors shall only report back to SPINCO such information as is directly relevant to informing SPINCO on compliance with the particular provisions that are the subject of the
audit. To the extent that AstraZeneca subcontracts any activities under this Agreement, AstraZeneca shall be responsible for auditing such subcontractors in accordance with the terms of its agreements with such third parties, provided that subject
to any confidentiality obligations all such subcontractor records held by AstraZeneca will be open for inspection during any audit of AstraZeneca. 

23.3.    Audit Assistance: AstraZeneca shall provide or procure all cooperation and assistance during normal working hours
reasonably required by SPINCO for the purposes of an audit. SPINCO shall procure that any auditor enters into a confidentiality agreement equivalent to Article 11 (Confidentiality) in all material respects. SPINCO shall instruct any auditor
or other person given access in respect of an audit to cause the minimum amount of disruption to the business of AstraZeneca, its Affiliates and sub-contractors and to comply with relevant building and
security regulations. 

  
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[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 23.4.    Audit Costs: The Parties shall bear their own costs of an audit or
rendering assistance under this Article 23, except where SPINCO requires the audit to be undertaken by its non-Affiliate Third Party professional advisors to verify AstraZeneca’s compliance with Article
21 (Compliance), in which case AstraZeneca shall arrange for the audit to take place and pay the fees of any such non-Affiliate Third Party professional advisors. In the event an underreporting
discrepancy of at least [***] of the total amount is found in any audit, AstraZeneca shall bear the entire cost of such audit in addition to promptly making any such underreported payment to SPINCO. 

  
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[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 PART C: DEFINITIONS & INTERPRETATION 

Definitions. In this Agreement: 
  

			
	Affiliate	  	means, with respect to a Person, any other Person that controls, is controlled by, or is under common control with such Person. For purposes of this Agreement, a Person will be deemed to control another Person if it owns or
controls, directly or indirectly, more than 50% of the equity securities of such other Person entitled to vote in the election of directors (or, in the case that such other Person is not a corporation, for the election of the corresponding managing
authority), or otherwise has the power to direct the management and policies of such other Person. The Parties acknowledge that in the case of certain entities organized under the laws of certain countries outside the United States, the maximum
percentage ownership permitted by law for a foreign investor may be less than 50%, and that in such case such lower percentage will be substituted in the preceding sentence; provided that such foreign investor has the power to direct the management
and policies of such entity. Notwithstanding the foregoing or anything else to the contrary herein or in the APA, for purposes of this Agreement, neither Party shall be considered an Affiliate of the other Party, notwithstanding the fact that SPINCO
may be considered an affiliate of AstraZeneca under the terms of other contracts to which AstraZeneca or its respective other affiliates may be a party;
		
	Affiliate Product Schedule	  	means a Product Schedule entered into by SPINCO and an Affiliate of AstraZeneca, as described in Section 2.1;
		
	APA	  	has the meaning set out in the “Background” heading at the start of this Agreement;
		
	Agreement	  	means: (i) this master agreement, or (ii) in the context of a particular Product Schedule, the agreement formed by the entry into that Product Schedule;
		
	Apparent Defects	  	has the meaning set out in Section 7.3.1;
		
	Applicable Laws and Regulations	  	means all national, supra-national, federal, state, local, foreign or provincial laws, rules, directives, regulations, including case law, as well as any guidance, guidelines and requirements of any Regulatory Authorities and any
industry codes of practice, in effect from time to time applicable to the activities performed under this Agreement;
		
	Arising IPR	  	has the meaning set out in Section 4.3;
		
	 Background
 IPR
	  	means all Intellectual Property Rights, results, data, inventions and information owned by either Party (or owned by a Third Party licensor but licensed to a Party with the right to disclose or
sub-license) prior to the date that the relevant Product Schedule comes into effect. Background IPR may be specified in the Product Schedule in the case of a Development Service Schedule;
		
	BLA	  	means, with respect to the Product, a Biologics License Application (as that term is defined in section 351(a) of the Public Health Service Act) or a New Drug Application (as that term is defined in section 505(b) of the FFDCA),
filed with the FDA in the United States with respect to the Product, or any corresponding foreign application or similar application or submission filed with a Regulatory Authority to obtain marketing approval for a biological or pharmaceutical
product in a country or group of countries;

  
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[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

			
	CMC Data	  	means the chemistry, manufacturing and controls data required by Applicable Laws and Regulations to be included or referenced in, or that otherwise supports, an IND or BLA for the Product;
		
	Confidential Information	  	means any technical, business or other information including Know-How that is (i) not generally known by the public and (ii) provided by or on behalf of one Party to the other Party
in connection with this Agreement, whether prior to, on or after the Effective Date, including information relating to the terms and conditions of this Agreement and the intention to enter into a Product Schedule and related discussions, information
relating to the Supplied Products, or the scientific, regulatory or business affairs or other activities of either Party;
		
	Current Good Manufacturing Practices or cGMP	  	means FDA’s current good manufacturing practices, as specified in the United States Code of Federal Regulations (CFR) 21 CFR Parts 11, 210, 211, 600-680 and 820 and FDA’s guidance
documents and all successor regulations and guidance documents thereto, and European Commission Directive 2003/94/EC, Eudralex Volume 4, and 93/42/EEC;
		
	Development Activities	  	means the activities to be conducted by either Party pursuant to any Product Schedule;
		
	Development Services	  	means the development services for a particular Product as described in the applicable Development Service Schedule. Examples of potential Development Services are set forth in Annex 1;
		
	Development Service Schedule	  	means a schedule completed and entered into between the Parties for development activities to be undertaken with respect to a Product;
		
	Documents	  	means reports, research notes, charts, graphs, comments, computations, analyses, recordings, photographs, paper, notebooks, books, files, ledgers, records, tapes, discs, diskettes, CD-ROM,
computer programs and documents, computer information storage means, samples of material, other graphic or written data and any other media on which Know-How can be stored;
		
	Effective Date	  	has the meaning set out under the “Parties” heading at the start of this Agreement;
		
	Existing Products	  	means MEDI-551, MEDI4920, MEDI7734, MEDI9600, MEDI1116 and Mabkine;
		
	Facility Change	  	has the meaning set forth in Section 8.6;
		
	FDA	  	means the USA Food and Drug Administration, or any successor thereto;
		
	FFDCA	  	means the Federal Food, Drug, and Cosmetic Act of the USA, as amended and may be amended from time to time, and the rules and regulations promulgated thereunder;
		
	Force Majeure	  	means any circumstances beyond a Party’s reasonable control, including accidents, civil disorders or commotions, riot, war, malicious damage, acts of terrorism, acts of God, Regulatory Authority-imposed energy or other
conservation measures, explosions, failure of utilities by the provider, disease, pandemic, quarantine, or theft;
		
	FTE Rate	  	has the meaning set forth in Section 10.1;

  
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[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

			
	Governmental Authority	  	means any nation or government or governmental or regulatory body thereof, or political subdivision thereof, whether federal, state, local or foreign, or any agency, instrumentality or authority thereof, or any court or arbitrator
(public or private) or any other entity exercising executive, judicial, legislative, regulatory or administrative functions of or pertaining to regulation or to government;
		
	IND	  	means an Investigational New Drug Application submitted under Section 505(i) of the FFDCA, or an analogous application or submission with any analogous agency or Regulatory Authority outside of the United States for the
purposes of obtaining permission to conduct clinical trials;
		
	Indemnitee	  	has the meaning set out in Section 13.4;
		
	Indemnifying Party	  	has the meaning set out in Section 13.4;
		
	Independent Expert	  	has the meaning set out in Section 7.6;
		
	Indirect Taxes	  	means value added taxes, sales taxes, consumption taxes and other similar Taxes that are required to be disclosed on an Indirect Tax invoice.
		
	Insolvency Event	  	means that a Party: (i) suspends, or threatens to suspend, payment of its debts or is unable to pay its debts as they fall due, (ii) commences negotiations with all or any class of its creditors with a view to rescheduling
any of its debts, or makes a proposal for or enters into any compromise or arrangement with its creditors, (iii) is the subject of a petition, notice, resolution or order for its winding up, (iv) has an administrator, administrative
receiver or receiver appointed over it or its assets or is the subject of any formal step taken as part of the process of making such an appointment, (v) has assets that a creditor or encumbrancer has attached or taken possession of, or in
respect of which a distress, execution, sequestration or other such process is levied or enforced on or sued against, or (vi) is subject to any similar event or proceeding in any jurisdiction;
		
	Intellectual Property Rights	  	means rights in Confidential Information including Know-How, along with all Patent Rights, trademarks, service marks, trade names, design rights, copyright (including rights in computer
software) and any similar or equivalent rights or property or forms of protection in any part of the world, whether registered or not, together with the right to apply for the registration of any such rights;
		
	IT Media	  	has the meaning set forth in Section 11.6;
		
	JDC	  	has the meaning set forth in Section 20.2;
		
	JSC	  	has the meaning set forth in Section 20.3;
		
	Know-How	  	means technical information, data and other information which is not in the public domain including: (i) information comprising or relating to concepts, discoveries, data, designs, formulae, ideas, inventions, methods, models,
assays, research plans, procedures, designs for experiments and tests and results of experimentation and testing (including results of research or development), processes (including manufacturing processes, specifications and techniques), laboratory
records, chemical, pharmacological, toxicological, clinical, analytical and quality control data, trial data, case report forms, data analyses, reports, manufacturing data or summaries, (ii) practices and instructions of, and scientific, analytical
and technical data and studies for, synthesis, manufacturing, pharmaceutical processing, formulation, packaging, labelling, storage and transportation, and (iii) non-clinical and clinical data and
studies. Know-How includes Documents containing Know-How. The fact that an item is known to the public shall not be taken to exclude the possibility that a compilation
including the item, and/or a development relating to the item, is not known to the public;

  
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[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

			
	Latent Defects	  	has the meaning set forth in Section 7.3.2;
		
	Licensed Manufacturing Technology	  	has the meaning set forth in Section 4.6.2;
		
	Losses	  	means any and all liabilities, claims, demands, causes of action, damages, loss, costs and expenses, including interest, penalties, reasonable professional fees and reasonable lawyers’ fees together with
disbursements;
		
	Manufacturing Change	  	has the meaning set forth in Section 8.2;
		
	Manufacturing Technology	  	means any Know-How that (a) is not generally known, (b) is owned or controlled by AstraZeneca or its Affiliates as of the Effective Date or during the Term, and (c) is necessary
for or used by AstraZeneca in manufacture of the Existing Products (before or after the Effective Date), or any Products hereunder;
		
	MedImmune Manufacturing Technology	  	means all Manufacturing Technology other than, with respect to a Product, the Licensed Manufacturing Technology (if any) included or used in the Transferable Manufacturing Process for such Product;
		
	New AZ IPR	  	has the meaning set out in Section 4.3;
		
	New SPINCO IPR	  	has the meaning set out in Section 4.3;
		
	 Non-

Conforming Product and Non-

Conformance
	  	means any Supplied Product which, at the time of delivery by AstraZeneca, does not conform with the requirements of Section 7.1;
		
	Out-of-Pocket Costs	  	means, with respect to any Services, (a) any amounts paid to Third Parties (including costs incurred by AstraZeneca or its Affiliates under Third Party contracts); (b) shipping and transportation costs (including the cost of
any insurance related thereto), duties and taxes; (c) travel-related costs from mutually-agreed-upon travel; (d) costs or expenses incurred by AstraZeneca, its Affiliates or subcontractors for the extraction, conversion and transfer of
data; (e) any costs and expenses described in a Development Service Schedule that are not included as Services fees; and (f) any other actual, reasonably incurred, documented,
out-of-pocket costs and expenses, in each case (a) through (f), directly incurred by AstraZeneca and its Affiliates in providing such Services;
		
	Parties	  	means SPINCO and AstraZeneca, and “Party” means either of SPINCO or AstraZeneca;
		
	Patent Rights	  	mean patent applications and patents (including but not limited to inventions, utility models and industrial designs), inventors’ and authors’ certificates, improvement patents, and patents of addition and administrative
protection (such as pipeline protection) and all foreign counterparts of them in any and all countries, and including any divisional applications and patents, re-filings, renewals, continuations, continuations-in-part, extensions (including patent term extensions and patent term adjustments), reissues, re-examinations,
substitutions, confirmations, registrations, revalidation, importation and additions, and any equivalents in any and all countries, as well as any supplementary protection certificates and equivalent protection rights in respect of any of them in
any and all countries;

  
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[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

			
		
	Person	  	means an individual, sole proprietorship, partnership, limited partnership, limited liability partnership, corporation, limited liability company, business trust, joint stock company, trust, incorporated association, joint venture
or similar entity or organization, including a Regulatory Authority;
		
	Personnel	  	means the employees, officers, agents and contractors of a Party (or, where the context requires, those of a Party’s Affiliates);
		
	Price	  	means the amount payable from time to time for a Supplied Product or Development Service, as determined in accordance with the terms of this Agreement and the relevant Product Schedule;
		
	Product	  	means an Existing Product or another product being developed by SPINCO, in each case as described in the applicable Product Schedule;
		
	Product Schedule	  	means: (i) a Development Service Schedule or a Supply Schedule, or (ii) in the context of an Agreement formed by a particular Product Schedule, the Product Schedule entered into to form the Agreement;
		
	Project Team	  	has the meaning set forth in Section 20.1;
		
	Purchase Order or PO	  	means, with respect to a Supply Schedule, a Purchase Order with a unique number issued by SPINCO and accepted by AstraZeneca stating either the batches to be run or the quantities of Products that SPINCO commits to purchase from
AstraZeneca and the anticipated delivery date;
		
	QAA	  	means the quality assurance agreement, as defined in Section 6.2, entered into by the Parties and/or their Affiliates from time to time, or where a quality assurance agreement has not been entered into, the agreed specification
and quality requirements relating to a Product;
		
	Records	  	has the meaning set forth in Section 23.1;
		
	Regulatory Approval	  	means, with respect to the Product and a particular country, any and all approvals (including approvals of BLA), licenses, registrations or authorizations of any Regulatory Authority necessary to develop, manufacture or
commercialize the Product in such country;
		
	Regulatory Authority	  	means any court or government body, whether national, supra-national, federal, state, local, foreign or provincial, including any political subdivision, including any department, commission, board, bureau, agency, or other
regulatory or administrative Governmental Authority or instrumentality, and further including any quasi-governmental person or entity exercising the functions of any of these;
		
	Remediation Plan	  	Has the meaning set forth in Section 16.2;
		
	Required Manufacturing Change	  	has the meaning set forth in Section 8.3;
		
	Services	  	means the services performed by AstraZeneca pursuant to a Product Schedule;
		
	Shortfall	  	means if applicable the quantity of a Supplied Product actually delivered to SPINCO that is less than the quantity set out in the Purchase Order unless the actual quantity delivered is only [***] than the amount ordered;
		
	Specification	  	means, with respect to a Supplied Product, the numerical limits, ranges, or other acceptance criteria for raw materials, intermediates, in process samples, or final products for such Supplied Product as attached to the applicable
Supply Schedule;

  
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[*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

			
	Supplied Product	  	means with respect to a Supply Schedule, the Product manufactured by AstraZeneca pursuant to that schedule;
		
	Supply Schedule	  	means a schedule completed and entered into between the Parties for the supply of a Product or related services. Examples of activities that may be undertaken pursuant to Supply Schedules are set out in Annex 2.
		
	Taxes	  	means and includes all forms of taxation, levy, impost or duty and any similar charge, contribution, deduction or withholding and all penalties, charges, surcharges, fines, costs and interest included in, or relating to, any of the
foregoing or to any obligation in respect of any of the foregoing;
		
	Term	  	means the term of a Product Schedule set out in the Product Schedule;
		
	Third Party	  	means any Person other than AstraZeneca, SPINCO and their respective Affiliates and permitted successors and assigns.
		
	Third Party Claim	  	has the meaning set forth in Section 13.1; and
		
	Transferable Manufacturing Processes	  	has the meaning set out in Section 4.6.1.

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 Interpretation 

In this Agreement: 
  

	1.	 Except where the context requires otherwise, whenever used the singular includes the plural, the plural
includes the singular, the use of any gender is applicable to all genders. 

  

	2.	 Whenever this Agreement refers to a number of days, unless otherwise specified, such number refers to calendar
days. 

  

	3.	 The term “including” or “includes” as used in this Agreement means including “without
limiting” or “without limitation”. 

  

	4.	 The word “or” is used in the inclusive sense, as in “and/or”. 

 

	5.	 Any reference to “US Dollars” or “$” is to the lawful currency from time to time of the
United States of America. 

  

	6.	 Any reference to a statute or statutory provision includes any successor legislation thereto, regulations
promulgated thereunder, any consolidation or re-enactment, modification or replacement thereof, any statute or statutory provision of which it is a consolidation,
re-enactment, modification or replacement and any subordinate legislation in force under any of the same from time to time except in each case to the extent that any consolidation, re-enactment, modification or replacement enacted after the date of this Agreement would extend or increase the obligations, in any manner (and whether financial obligations or otherwise), of either Party hereunder.

  

	7.	 References to Articles, Sections and Parts refer to the Articles, Sections and Parts of and to this Agreement.
References to items are to items of the Product Schedule. 

  

	8.	 Unless otherwise expressly stated or the context otherwise requires, if there is any inconsistency between:

  

	 	a.	 the Product Schedule and any of the remainder of the terms of this Agreement, the terms of the Product Schedule
shall take precedence; 

  

	 	b.	 any Purchase Order and this Agreement, this Agreement shall control; and 

 

	 	c.	 the provisions of the QAA (as defined in Section 6.2) and the provisions of this Agreement, the provisions
of this Agreement shall prevail, except that with respect to matters related to quality, the QAA shall prevail. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 Annex 1 

Potential Development Services 
 Examples
of Development Services to be provided pursuant to this Agreement subject to the terms of Development Service Schedules to be entered into by SPINCO and AstraZeneca or one or more AstraZeneca Affiliates. 

Development activities 
 [***] 

[***] 
 [***] 

[***] 
 [***] 

[***] 
 [***] 

[***] 
 [***] 

[***] 
 [***] 

[***] 
 [***] 

[***] 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. 

 Annex 2 

Potential Activities under Supply Schedules 

Examples of activities that may be undertaken pursuant to Supply Schedules to be entered into by SPINCO and AstraZeneca or one or more AstraZeneca Affiliates
are as follows: 
 [***] 
 [***] 

[***] 
 [***] 

[***] 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.EX-10.18

 Exhibit 10.18 

TRANSITION SERVICES AGREEMENT 

BY AND BETWEEN 

MEDIMMUNE, LLC, 
 AND

 VIELA BIO, INC. 

DATED AS OF FEBRUARY 23, 2018 

 TABLE OF CONTENTS 

 
  

							
	 	  	 	  	Page	 
	ARTICLE 1 DEFINITIONS	  	 	1	 
			
	 1.1
	  	Certain Defined Terms	  	 	1	 
	 1.2
	  	Construction	  	 	2	 
		
	ARTICLE 2 SERVICES	  	 	3	 
			
	 2.1
	  	Provision of Services	  	 	3	 
	 2.2
	  	Services Performed by Affiliates and Third Parties	  	 	3	 
	 2.3
	  	Services Standard	  	 	4	 
	 2.4
	  	Transitional Nature of Services; Changes	  	 	4	 
	 2.5
	  	Location of Services Provided; Travel Expenses	  	 	5	 
	 2.6
	  	Transition Management	  	 	5	 
	 2.7
	  	Cooperation	  	 	5	 
	 2.8
	  	Consents	  	 	6	 
	 2.9
	  	Exclusions	  	 	6	 
		
	ARTICLE 3 COMPENSATION	  	 	7	 
			
	 3.1
	  	Services Fees	  	 	7	 
	 3.2
	  	Invoicing	  	 	7	 
	 3.3
	  	Due Date	  	 	7	 
	 3.4
	  	Taxes	  	 	7	 
	 3.5
	  	Records; Audit	  	 	8	 
		
	ARTICLE 4 OWNERSHIP OF ASSETS, INTELLECTUAL PROPERTY AND RIGHTS OF REFERENCE	  	 	9	 
			
	 4.1
	  	Ownership; Delivery	  	 	9	 
	 4.2
	  	Limited License	  	 	9	 
		
	ARTICLE 5 CONFIDENTIALITY	  	 	9	 
			
	 5.1
	  	Confidentiality	  	 	9	 
		
	ARTICLE 6 LIMITATION OF LIABILITY; INDEMNIFICATION	  	 	9	 
			
	 6.1
	  	Limitation of Liability	  	 	9	 
	 6.2
	  	Indemnification	  	 	10	 
	 6.3
	  	Exclusivity	  	 	11	 
		
	ARTICLE 7 TERM AND TERMINATION	  	 	11	 
			
	 7.1
	  	Term	  	 	11	 
	 7.2
	  	Termination of Services	  	 	11	 
	 7.3
	  	Accrued Rights; Surviving Obligations	  	 	12	 
		
	ARTICLE 8 MISCELLANEOUS	  	 	13	 
			
	 8.1
	  	Force Majeure	  	 	13	 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 TABLE OF CONTENTS 

(continued) 
  

							
	 	  	 	  	Page	 
	 8.2
	  	Independent Contractor	  	 	13	 
	 8.3
	  	Governing Law, Jurisdiction, Venue and Service	  	 	13	 
	 8.4
	  	Notices	  	 	14	 
	 8.5
	  	No Benefit to Third Parties	  	 	15	 
	 8.6
	  	Waiver and Non-Exclusion of Remedies	  	 	15	 
	 8.7
	  	Assignment	  	 	15	 
	 8.8
	  	Amendment	  	 	16	 
	 8.9
	  	Severability	  	 	16	 
	 8.10
	  	English Language	  	 	16	 
	 8.11
	  	Counterparts	  	 	17	 
	 8.12
	  	Entire Agreement	  	 	17	 
		
	 SCHEDULES

 
	  			
	 2.1
	  	Services and Fees	  			

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 INDEX OF DEFINED TERMS 

 

					
	Defined	  	 	Page	 
	Agreement	  	 	1	 
	Assignment	  	 	16	 
	AZ Liability Cap	  	 	10	 
	AZ-Related Losses	  	 	2	 
	Breaching Party	  	 	12	 
	Calendar Year	  	 	1	 
	Effective Date	  	 	1	 
	Excluded Services	  	 	1	 
	Force Majeure Event	  	 	13	 
	FTE	  	 	2	 
	FTE Rate	  	 	2	 
	Indirect Taxes	  	 	2	 
	Notice	  	 	14	 
	Notice Period	  	 	12	 

					
	Defined	  	 	Page	 
	Out-of-Pocket Costs	  	 	2	 
	Parties	  	 	1	 
	Party	  	 	1	 
	Payments	  	 	8	 
	Program IP	  	 	9	 
	Service	  	 	3	 
	Service Period	  	 	12	 
	Services	  	 	3	 
	Services Fees	  	 	7	 
	Services Standard	  	 	4	 
	Spinco	  	 	1	 
	Spinco Liability Cap	  	 	11	 
	Transition Managers	  	 	5	 
	Transition Period	  	 	12	 

 
 

  

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 TRANSITION SERVICES AGREEMENT 

TRANSITION SERVICES AGREEMENT (this “Agreement”) dated as of February 23, 2018 (the “Effective
Date”), between MEDIMMUNE, LLC, a Delaware limited liability company (“AZ”), and Viela Bio, Inc., a Delaware corporation (“Spinco”). AZ and Spinco are sometimes referred to herein individually as a
“Party” and collectively as the “Parties”. 
 WHEREAS, AZ, MedImmune Limited, Astrazeneca
Collaboration Ventures LLC and Spinco are parties to that certain Asset Purchase Agreement, dated as of February 23, 2018 (the “APA”), pursuant to which AZ has agreed to sell, or to procure the sale of, the Acquired Assets (as
defined in the APA) to Spinco on the terms and subject to the conditions specified therein; and 
 WHEREAS, as part of the APA, as an
accommodation to Spinco, AZ has agreed to perform certain Services for certain periods after the Effective Date for the benefit of Spinco with respect to Spinco’s use and operation of the Acquired Assets on the terms and subject to the
conditions contained herein. 
 NOW, THEREFORE, in consideration of the premises and the mutual agreements and covenants hereinafter
set forth and set forth in the APA and the other Transaction Agreements (as defined in the APA), and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, do
hereby agree as follows: 
 ARTICLE 1 

DEFINITIONS 

1.1    Certain Defined Terms. Unless otherwise specifically provided herein, capitalized terms used, but not
otherwise defined, herein shall have the meanings ascribed thereto in the APA. As used herein, the following terms have the following meanings. 

“AZ-Related Losses” means any Losses to the extent such Losses are caused by
(a) the gross negligence or willful or intentional misconduct of AZ or any of its Affiliates or subcontractors in connection with or (b) any material breach by AZ or any of its Affiliates or subcontractors of, this Agreement. 

“Calendar Year” means each successive period of 12 calendar months commencing on January 1 and ending on
December 31, except that the first Calendar Year of the Transition Period shall commence on the Effective Date and end on December 31 of the year in which the Effective Date occurs and the last Calendar Year of the Transition Period shall
commence on January 1 of the year in which the Transition Period ends and end on the last day of the Transition Period. 

“Excluded Services” means all services not specifically covered by Schedule 2.1. 

  
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INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 “FTE Rate” means an [***] (“FTE”) person year (consisting
of a total [***]) of work, pro-rated on a daily basis. Without limiting the above, the FTE Rate shall be adjusted annually for each Calendar Year after the Calendar Year ending December 31, 2018 to be
equal to the FTE Rate for the preceding Calendar Year plus a percentage increase equal to the percentage increase in such Calendar Year in the applicable Consumer Price Index for all Urban Consumers, as published by the U.S. Department of Labor,
Bureau of Statistics. 
 “Indirect Taxes” means value added taxes, sales taxes, consumption taxes and other similar Taxes
that are required to be disclosed on an Indirect Tax invoice. 

“Out-of-Pocket Costs” means, with respect to
any Services, (a) any amounts paid to Third Parties (including costs incurred by AZ or its Affiliates under Third Party Contracts); (b) fees associated with securing any consents required from Third Party contractors; (c) shipping and
transportation costs (including the cost of any insurance related thereto), duties and taxes; (d) travel-related costs in accordance with Section 2.5; (e) costs or expenses incurred by AZ, its Affiliates or
subcontractors for the extraction, conversion and transfer of data; (f) those costs and expenses described in Schedule 2.1 that are not included in the Services Fees; and (g) any other actual, reasonably incurred,
documented, out-of-pocket costs and expenses, in each case ((a) through (g)) incurred by AZ and its Affiliates directly in providing such Services. 

“Tax” shall have the meaning set forth in the APA. 

1.2    Construction. Except where the context otherwise requires, wherever used, the singular includes the plural,
the plural the singular, the use of any gender shall be applicable to all genders and the word “or” is used in the inclusive sense (and/or). The table of contents and captions of this Agreement are for convenience of reference only and in
no way define, describe, extend or limit the scope or intent of this Agreement or the intent of any provision contained in this Agreement. The term “including” or its variations as used herein does not limit the generality of any
description preceding such term and shall be construed as “including, without limitation.” The language of this Agreement shall be deemed to be the language mutually chosen by the Parties and no rule of strict construction shall be applied
against either Party. Unless otherwise specified or where the context otherwise requires, (a) references in this Agreement to any Article, Section, Schedule or Exhibit are references to such Article, Section, Schedule or Exhibit of this
Agreement, and references to this “Agreement” are references to this Agreement and all exhibits and schedules hereto; (b) references in any Section to any clause are references to such clause of such Section;
(c) “hereof,” “hereto,” “hereby,” “herein” and “hereunder” and words of similar import when used in this Agreement refer to this Agreement as a whole and not to any particular provision of this
Agreement; (d) references to a Person are also to its permitted successors and assigns; (e) references to a Law include any amendment or modification to such Law and any rules, regulations or legally binding guidelines issued thereunder,
in each case, as in effect at the relevant time of reference thereto; (f) references to any agreement, instrument or other document in this Agreement refer to such agreement, instrument or other document as originally executed or, if
subsequently amended, replaced or supplemented from time to time, as so amended, replaced or supplemented and in effect at the relevant time of reference thereto; (g) “extent” in the phrase “to the extent” means the degree to
which a subject or other thing extends, and such phrase does not mean simply “if”; (h) references to monetary amounts are denominated in United States Dollars; and (i) references to days (excluding Business Days) or months shall
be deemed references to calendar days or months. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 ARTICLE 2 

SERVICES 

2.1    Provision of Services. 

2.1.1    Subject to the terms and conditions of this Agreement, during the Transition Period, AZ shall provide or cause to
be provided to Spinco the transitional services set forth on Schedule 2.1, as such services are currently being utilized by AZ in connection with the Programs (each, a “Service” and collectively, the
“Services”), when and as reasonably requested by Spinco or its Affiliates. 
 2.1.2    If there is any
inconsistency between the terms of Schedule 2.1 and the terms of this Agreement, the terms of this Agreement shall govern. Except as expressly set forth herein, from and after the Effective Date, AZ’s and Spinco’s respective
obligations and rights with respect to the Products and the Programs shall be as set forth in the APA or the applicable other Transaction Agreements. For the avoidance of doubt, the Services do not include, and AZ shall have no obligation to
provide, any Excluded Services. 
 2.1.3    Notwithstanding anything to the contrary herein, AZ will not be required to
perform or to cause to be performed any of the Services for the benefit of any Person other than Spinco and its Affiliates. 

2.1.4    In the event that Spinco wishes to change the Services set forth on Schedule 2.1 (including adding an
additional service or services) from time to time throughout the Transition Period, the Parties shall negotiate in good faith amendments to Schedule 2.1 to this Agreement to implement such change, including reasonable changes in the
applicable Services Fees set forth on Schedule 2.1. 
 2.2    Services Performed by Affiliates and Third
Parties. AZ shall have the right to perform the Services itself, through any Affiliate or through any subcontractor; provided however that, (a) in the event that any Service is performed by AZ through a subcontractors, AZ shall notify
Spinco that such subcontractor is performing such Service and (b) in the event that any Service is performed by AZ through an Affiliate or a subcontractor, AZ shall remain responsible for the performance of such Affiliate or subcontractor as if
such Services were performed by AZ itself. AZ shall have also have the right to engage a third party contractor to substitute for AZ and contract directly with Spinco to provide any Service to Spinco upon Spinco’s prior written approval (such
approval not be unreasonably withheld or delayed), provided that AZ believes in good faith that such third party contractor is qualified and able to provide such Service consistent with the Services Standard (as defined below), in which case,
AZ’s obligation to provide such Service to Spinco, and Spinco’s obligation to pay the applicable Service Fee to AZ, shall be terminated solely to the extent such Service is carried out by such third party contractor. In such case, Spinco
agrees to enter into a customary services agreement reasonably acceptable to Spinco directly with such third party contractor to provide any such Service for the fees specified therein. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 2.3    Services Standard. 

2.3.1    Spinco acknowledges that AZ is not in the business of providing services to Third Parties and is entering into
this Agreement only in connection with the APA and the Securities Purchase Agreement. AZ shall, and shall cause its Affiliates and subcontractors to, provide the Services to be provided pursuant to this Agreement with substantially the same degree
of skill, quality and care utilized by AZ (or its Affiliates) in the [***] period prior to Closing in performing such activities for itself with respect to the Products and in compliance in all material respects with applicable Law (the
“Services Standard”). Under no circumstances shall AZ, its Affiliates or its or their respective employees or agents (including subcontractors) be held accountable to a greater standard of care, efforts or skill than the Services
Standard with respect to the performance of Services under this Agreement. Spinco acknowledges and agrees that (a) the Services do not include the exercise of business judgment or general management for Spinco and (b) EXCEPT AS EXPRESSLY
SET FORTH IN THIS AGREEMENT, NEITHER AZ NOR ANY OF ITS AFFILIATES MAKES ANY REPRESENTATIONS OR WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE SERVICES. 

2.3.2    If Services to be provided to Spinco increase in scale or in scope in a material way beyond those provided to AZ
itself as of the Effective Date, AZ shall so inform Spinco and, upon Spinco’s request, the Parties shall negotiate in good faith such increased scale or scope of Services as a change to the Services as set forth in Section 2.1.4. If no
agreement is reached by the Parties in connection with such increased scale or scope of Services, AZ shall have no obligation to provide such expanded scale or scope of Services. 

2.3.3    If, in order to provide any Services under this Agreement, the Parties agree that it is necessary or advisable to
take any steps to facilitate such Services, including implementing special information technology connections or firewalls, the costs of taking such steps shall be borne by Spinco unless otherwise agreed by the Parties. 

2.4    Transitional Nature of Services; Changes. Spinco acknowledges and agrees that (a) the Services are
intended only to be transitional in nature, and shall be furnished by AZ only during the Transition Period and solely for the purpose of accommodating Spinco in connection with the transactions contemplated by the APA and (b) following the
Transition Period, Spinco will need to perform the Services (or have the Services performed by other third parties) without the involvement of AZ, its Affiliates or any of its or their respective employees or agents. Spinco acknowledges that the
Services are being furnished in support of Spinco’s personnel and under no circumstances shall AZ be required to fulfill or serve as a substitute for any personnel role of Spinco. Spinco acknowledges and agrees that AZ or its Affiliates may
make changes from time to time in its manner of performing the Services if such changes do not materially impact Spinco or the Programs and AZ or its Affiliates (a) are making similar changes in performing similar services for their own
Affiliates and (b) if applicable, furnish to Spinco substantially the same notice (in content and timing) as AZ or its Affiliates shall furnish to their own Affiliates with respect to such changes. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 2.5    Location of Services Provided; Travel Expenses. AZ shall
provide the Services to Spinco from locations of AZ’s choice in its sole discretion unless Services are required to be performed at a specific location identified in Schedule 2.1. Should the provision of Services require any personnel of
AZ to travel beyond 50 miles from his or her employment location, Spinco shall reimburse AZ for all reasonable travel-related costs, consistent with AZ’s travel policy. Travel time of any FTE in connection with any Service, calculated
consistent with AZ’s travel policy, shall be included in the maximum hours allocated to such Service. 

2.6    Transition Management. Within five Business Days after the Effective Date, Spinco and AZ each shall
designate an appropriate point of contact for all questions and issues relating to the Services (the “Transition Managers”). Either Party may, by written notice given to the other Party, replace its Transition Manager. As soon as
reasonably practicable following the Effective Date, the Parties shall commence planning for full transition of all Services to Spinco through the respective Transition Managers and shall designate teams and team leads with respect to each of the
functional-related Services. The Transition Managers shall meet at least once per month, or on such other schedule as mutually agreed upon by the Parties, during the Transition Period in person or telephonically in order to discuss the Services and
the status of the transition and to manage any open issues relating to the Services. 
 2.7    Cooperation. Each
of Spinco and AZ shall use commercially reasonable efforts to cooperate with each other in all matters relating to the provision and receipt of the Services. Without limiting the generality of the foregoing sentence: 

2.7.1    Such cooperation shall include AZ using commercially reasonable efforts to obtain material consents, licenses or
approvals necessary to permit AZ to perform its obligations hereunder; provided, however, that under no circumstances shall AZ be obligated to provide a Service if (a) AZ is unable to obtain necessary consents, licenses and approvals
relating to such Service on commercially reasonable terms; (b) in order to provide such Service, AZ will have an obligation to make any payments to any Third Party or incur any obligations in respect of any such consents, licenses or approvals,
which payments are not subject to reimbursement by Spinco or which other obligations are not assumed by Spinco hereunder; (c) AZ would be obligated to make any alternative arrangements in the event that any such consents, licenses or approvals
are not obtained (but only to the extent such arrangements would not be commercially reasonable); or (d) AZ would be required to seek materially broader rights or more favorable terms with respect to any consents, licenses or approvals than
those applicable immediately prior to the date hereof. 
 2.7.2    Spinco shall permit AZ, its Affiliates and its and
their respective employees and agents reasonable access during regular business hours (or otherwise upon reasonable prior notice) to such data and personnel as are involved in receiving or overseeing the Services, and records as reasonably requested
by AZ to facilitate AZ’s performance of this Agreement. 
 2.7.3    AZ shall be excused from its obligation to
provide a Service under this Agreement to the extent Spinco’s failure to perform its obligations under this Agreement materially hinders or prevents AZ’s performance of its obligation, including if the provision of a Service is dependent
or otherwise materially reliant on Spinco timely providing to AZ or any of 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 
its Affiliates or subcontractors information, materials, products and like items in a manner substantially similar in nature, quality and timeliness to the information, materials, products and
like items provided to AZ, its Affiliates or subcontractors in connection with the Programs at the time of the Closing and Spinco, at its sole cost and expense, fails to so provide such information, materials, products and like items during the
Transition Period. In the event AZ believes that Spinco has failed to provide any such information, materials, products or like items or otherwise has failed to perform Spinco’s obligations under this Agreement, without limitation of AZ’s
rights and remedies hereunder, the Transition Manager of AZ shall provide notice of such alleged failure to the Transition Manager of Spinco and the Transition Managers shall discuss and work together in good faith to resolve any impact such alleged
failure may have to the provision of the Services. 
 2.8    Consents. To the extent the consent of any Third
Party is needed in order for AZ to use any resources to provide the Services, Spinco shall (a) cooperate with AZ in acquiring any such consents; (b) comply with any requirements imposed on Spinco in connection with securing such consent;
(c) comply with any restrictions imposed on the use of such resources; and (d) be responsible for any fees payable to such Third Party to the extent necessary to secure the consent. Notwithstanding the foregoing or anything herein to the
contrary, if AZ is unable to secure such consents in accordance with Section 2.7.1 or Spinco fails to comply with any requirement contemplated in Section 2.8(b), AZ’s sole liability, and Spinco’s sole remedy, will be for AZ to
assist Spinco in identifying alternate resources for such Services and will use commercially reasonable efforts to assist Spinco in obtaining such resources. AZ will notify Spinco of any requirement for Third Party consent as soon as reasonably
practicable after becoming aware of such requirement. To AZ’s Knowledge, there are no Third Party consents required for AZ to provide the Services contemplated as of the Effective Date. 

2.9    Exclusions. Subject to the Services Standard, in no event shall AZ be (a) obligated to provide any
Services that would be unlawful for AZ to provide or that would require AZ to violate applicable Law; (b) obligated to provide any Services that in AZ’s reasonable determination would create material deficiencies in AZ’s controls over
financial information or materially adversely affect the maintenance of AZ’s financial books and records or the preparation of its financial statements; (c) obligated to hire any additional employees to perform the Services or maintain the
employment of any specific employee; (d) obligated to hire replacements for employees that resign, retire or are terminated; (e) obligated to enter into retention agreements with employees or otherwise provide any incentive beyond payment
of regular salary and benefits; (f) prevented from transferring after the Effective Date any employees (other than Transferred Employees) who were supporting the Programs as of the Effective Date to support other products for AZ or its
Affiliates or to assume other roles with AZ or its Affiliates to the extent such employees are not required to provide Services; (g) prevented from determining, in its reasonable discretion, the individual employees who will provide Services;
(h) obligated to purchase, lease or license any additional equipment or software; (i) obligated to create or supply any documentation or information not currently existing or reasonably available; (j) obligated to enter into new or
additional Contracts with Third Parties or change the scope of current Contracts with Third Parties or take any actions that would result in the breach of any Third Party Contracts of AZ; or (k) obligated to provide any Service to the extent
and for so long as the performance of such Service becomes impracticable as a result of a 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 
Force Majeure Event (as defined below); provided, however in the case of (b) and (k) that AZ promptly notifies Spinco of such occurrence; provided, further, that in the event AZ is unable to
provide any Service as a result of the occurrence of any event described in the foregoing clauses (a) through (k), AZ shall reasonably cooperate with Spinco with respect to any reasonably necessary transition assistance reasonably requested by
Spinco in good faith. 
 ARTICLE 3 

COMPENSATION 

3.1    Services Fees. In consideration for the performance of the Services by AZ, Spinco shall pay the applicable
fees therefor set forth on Schedule 2.1 (the “Services Fees”); provided, that if the Parties mutually agree that the Service Period for any Service should be extended beyond the Service Period stated in
Schedule 2.1, the Service Fee for such Service shall be increased to equal (a) [***] of the applicable Service Fee stated in Schedule 2.1 for the initial extension of such Service Period and (b) [***] of the applicable Service Fee stated in
Schedule 2.1 for a second extension of such Service Period. In addition, Spinco shall reimburse AZ for any Out-of-Pocket Costs, not to exceed [***] per single expense
without Spinco’s prior approval (such approval not to be unreasonably withheld, conditioned or delayed and with respect to Out-of-Pocket Costs exceeding [***] per
single expense, upon receipt of applicable receipts and other reasonable supporting documentation). Notwithstanding the foregoing, upon Spinco’s reasonable request from time to time, AZ shall provide reasonable supporting documentation of its Out-of-Pocket Costs less than [***] but exceeding [***] per single expense if Spinco reasonably determines in good faith that such documentation is necessary for its bona fide
accounting purposes. 
 3.2    Invoicing. AZ shall, on a calendar monthly basis, invoice Spinco for applicable
Services Fees and Out-of-Pocket Costs. [***]. 

3.3    Due Date. Spinco shall pay each invoice for Services Fees and Out-of-Pocket Costs promptly, but in no event later than [***] [***], after the date of receipt of such invoice. Any payments under this Agreement that are not made on or before the applicable due date shall
bear [***], as reported in the print edition of The Wall Street Journal, Eastern Edition, on the date such payment was due or, if unavailable, on the latest date prior to the payment due date on which such rate is available, and (b) [***]

 3.4    Taxes. 

3.4.1    The amounts payable by Spinco to AZ pursuant to this Agreement (“Payments”) shall not be reduced
on account of any Taxes unless required by applicable Law. AZ alone shall be responsible for paying any and all Taxes (other than withholding Taxes required to be paid by Spinco) levied on account of, or measured in whole or in part by reference to,
any Payments it receives. Spinco shall deduct or withhold from the Payments any Taxes that it is required by applicable Law to deduct or withhold. To the extent that any such Tax is deducted or withheld, such amount shall be treated for all purposes
of the Agreement as having been paid to the Person in respect of which such deduction or withholding was made. Notwithstanding the foregoing, if AZ is entitled under any applicable Tax treaty to a reduction of rate of, or the elimination of, or
recovery of, applicable withholding Tax, it shall deliver to 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 
Spinco or the appropriate Governmental Authority (with the assistance of Spinco to the extent that this is reasonably required and is expressly requested in writing) the prescribed forms
necessary to reduce the applicable rate of withholding or to relieve Spinco of its obligation to withhold Tax, and Spinco shall apply the reduced rate of withholding, or dispense with the withholding, as the case may be, to the extent it complies
with the applicable Tax treaty. If, in accordance with the foregoing, Spinco withholds any amount, it shall make timely payment to the proper Taxing Authority of the withheld amount, and send to AZ proof of such payment within 60 days following that
payment. 
 3.4.2    All Payments are stated exclusive of Indirect Taxes. If any Indirect Taxes are chargeable in
respect of any Payments, Spinco shall pay such Indirect Taxes at the applicable rate in respect of any such Payments following the receipt, where applicable, of an Indirect Taxes invoice in the appropriate form issued by AZ in respect of such
Payments, such Indirect Taxes to be payable on the due date of the payment of the Payments to which such Indirect Taxes relate. AZ shall issue its invoices for all amounts payable under this Agreement consistent with Indirect Tax requirements and
irrespective of whether the sums may be netted for settlement purposes. 
 3.5    Records; Audit. 

3.5.1    AZ shall keep and maintain, and shall cause its Affiliates to keep and maintain, complete and accurate records and
books of account documenting all expenses and all other data necessary for the calculation of the amounts payable by Spinco under this Agreement consistent with its standard procedures and policies in the ordinary course of business for a period of
two years after such expenses are incurred, unless a longer retention period is required by applicable Law. 

3.5.2    Upon Spinco’s request, AZ shall, and shall cause each of its Affiliates engaged in the performance of
activities under this Agreement to, permit Spinco and its Representatives to inspect and audit the records and books of account maintained by it pursuant to Section 3.5.1 in order to confirm the accuracy and completeness of such records and
books of account and all payments hereunder; provided, that Spinco shall not be entitled to exercise its inspection and audit rights under this Section 3.5.2 more than once per Calendar Year, unless, in any case, any prior audit resulted
in an adjustment to amounts due hereunder. Spinco shall bear all out-of-pocket costs and expenses incurred in connection with any inspection or audit performed pursuant
to this Section 3.5.2; provided, however, that AZ shall reimburse Spinco for all reasonable costs and expenses incurred by Spinco in connection with such inspection or audit if any such audit identifies an overpayment to AZ hereunder in
excess of [***] of the amount subject to the audit. In any case, the full amount of any overpayment or underpayment as applicable shall be payable to the applicable Party plus accrued interest at a rate equal to the lesser of (a) [***] above the
Prime Rate, as reported in the print edition of The Wall Street Journal, Eastern Edition, on the date such payment was due or, if unavailable, on the latest date prior to the payment due date on which such rate is available, and (b) [***].
All information disclosed pursuant to this Section 3.5.2 shall be subject to the non-disclosure and non-use provisions set forth in Article 5. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 ARTICLE 4 

OWNERSHIP OF ASSETS, INTELLECTUAL PROPERTY AND RIGHTS OF REFERENCE 

4.1    Ownership; Delivery. This Agreement and the performance of the Services hereunder shall not affect the
ownership of any intellectual property rights or other assets of the Parties. Subject to Section 4.2, neither Party shall gain, by virtue of this Agreement or the Services hereunder, by implication or otherwise, any rights of ownership or use
of any property or intellectual property rights owned by the other. All intellectual property conceived or made by AZ, its Affiliates or its subcontractors in the course of AZ’s performance of Services and other activities under this Agreement
(excluding any of Spinco’s Confidential Information embodied therein) and all intellectual property rights in the foregoing shall be solely owned by AZ, other than such intellectual property that exclusively relates to the Products or the
Programs and all intellectual property rights in the foregoing (“Program IP”), which rights shall be solely owned by Spinco and AZ hereby assigns all of its right, title and interest in and to such Program IP to Spinco, in each
case, unless otherwise expressly set forth in the APA or any of the other Transaction Agreements. In addition, except as reasonably required for the performance of the Services as set forth in this Agreement, under no circumstances shall AZ be
obligated to deliver or provide to Spinco, or otherwise make available or provide Spinco access to, any item which AZ is not otherwise obligated to provide to Spinco under the terms of the APA or any of the other Transaction Agreements. 

4.2    Limited License. Solely for and with respect to performance of Services and other activities under this
Agreement during the Transition Period, Spinco (on behalf of itself and its Affiliates) hereby grants to AZ and its Affiliates a non-exclusive, royalty-free,
non-transferable license and right of reference, with the right to grant further licenses and rights of reference to those Affiliates and subcontractors performing Services hereunder, to all Regulatory
Materials, Documents included within the APA, and all intellectual property rights owned or controlled by Spinco, in each case, that are necessary to perform the Services hereunder. 

ARTICLE 5 

CONFIDENTIALITY 

5.1    Confidentiality. Section 7.2 of the APA is hereby incorporated by reference into this Agreement,
mutatis mutandis. 
 ARTICLE 6 

LIMITATION OF LIABILITY; INDEMNIFICATION 

6.1    Limitation of Liability. None of AZ, its Affiliates or any employees or agents of AZ or its Affiliates shall
be liable to Spinco or its Affiliates for, and Spinco, on behalf of itself and its Affiliates, releases and forever discharges AZ, its Affiliates and any employees or agents of AZ and its Affiliates, from any and all Losses arising out of or
connected with any act or omission of AZ, its Affiliates or any employees or agents of AZ or its Affiliates pursuant to this Agreement or with respect to the Services, other than AZ-Related Losses.
NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS AGREEMENT, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW AND 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 
EXCEPT AS A RESULT OF COMMON LAW FRAUD IN CONNECTION WITH MATTERS COVERED HEREIN OR A PARTY’S BREACH OF ITS CONFIDENTIALITY OBLIGATIONS HEREUNDER, NEITHER SPINCO NOR AZ SHALL BE LIABLE TO
THE OTHER OR THEIR AFFILIATES, FOR ANY CLAIMS, DEMANDS OR SUITS FOR CONSEQUENTIAL, INCIDENTAL, SPECIAL, EXEMPLARY, PUNITIVE, INDIRECT OR MULTIPLE DAMAGES, FOR LOSS OF PROFITS, REVENUE OR INCOME, DIMINUTION IN VALUE OR LOSS OF BUSINESS OPPORTUNITY
(IN EACH CASE, WHETHER OR NOT FORESEEABLE AT THE EFFECTIVE DATE), OR FOR ANY DAMAGES CALCULATED BY REFERENCE TO A MULTIPLIER OF REVENUE, PROFITS, EBITDA OR SIMILAR METHODOLOGY, CONNECTED WITH OR RESULTING FROM ANY BREACH OF THIS AGREEMENT, OR ANY
ACTIONS UNDERTAKEN IN CONNECTION WITH, OR RELATED HERETO, INCLUDING ANY SUCH DAMAGES WHICH ARE BASED UPON BREACH OF CONTRACT, TORT (INCLUDING NEGLIGENCE AND MISREPRESENTATION), BREACH OF WARRANTY, STRICT LIABILITY, STATUTE, OPERATION OF LAW OR ANY
OTHER THEORY OF RECOVERY. Except as a result of common law fraud by AZ or its Affiliates or subcontractors in connection with matters covered herein, the maximum aggregate liability of AZ and its Affiliates to Spinco and any of its Affiliates with
respect to this Agreement shall (x) be, with respect to any particular Service provided hereunder, [***] (the “AZ Liability Cap”). Spinco and its Affiliates shall exercise all reasonable efforts to minimize the cost of any such
alternatives to the Services by selecting the most cost-effective alternatives which, in Spinco’s reasonable judgment, provide a reasonably comparable equivalent of the Services replaced. Except as a result of common law fraud by Spinco
or its Affiliates in connection with matters covered herein, the maximum aggregate liability of Spinco and its Affiliates to AZ and any of its Affiliates with respect to this Agreement shall be, with respect to any particular Service provided
hereunder, [***] (the “Spinco Liability Cap”). 
 6.2    Indemnification. Except as set
forth in the APA and the other Transaction Documents with respect to matters covered thereby and subject to this Article 6, Spinco shall indemnify and hold harmless AZ and its Affiliates and subcontractors, and each of their respective officers,
directors, employees and agents, from and against, and compensate and reimburse them for, any and all Losses (other than AZ-Related Losses) incurred by any such Person in connection with any Third Party claims
to the extent arising from or relating to (a) the acts or omissions of Spinco, its Affiliates, employees, suppliers, agents or subcontractors in connection with this Agreement; (b) any performance or failure to perform by Spinco, its
Affiliates, employees, suppliers, agents or subcontractors under this Agreement; or (c) the performance by AZ, its Affiliates or its subcontractors of AZ’s obligations in accordance with this Agreement; provided, that the maximum
aggregate liability of Spinco and its Affiliates under this Section 6.2 for such Losses shall not exceed the Spinco Liability Cap (except for any such Losses resulting from common law fraud by Spinco or its Affiliates in connection with matters
covered herein). Subject to this Article 6, AZ shall indemnify and hold harmless Spinco 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 
and its Affiliates, and each of their respective officers, directors, employees and agents, from and against, and compensate and reimburse them for, any
AZ-Related Losses incurred by any such Person in connection with any Third Party claims; provided, that the maximum aggregate liability of AZ and its Affiliates under this Section 6.2 for AZ-Related Losses shall not exceed the AZ Liability Cap (except for any AZ-Related Losses resulting from common law fraud by AZ or its Affiliates or subcontractors in
connection with matters covered herein). All indemnification claims made pursuant to this Section 6.2 shall be governed by and subject to the procedures set forth in Article IX of the APA, mutatis mutandis. 

6.3    Exclusivity. Except in the case of common law fraud in connection with matters covered herein, and except
for equitable remedies that may be available to a Party, to the maximum extent permitted by applicable Law, each Party’s and its Affiliates’ sole and exclusive remedy with respect to any and all Third Party claims relating to this
Agreement shall be pursuant to the indemnification provisions set forth in this Article 6. 
 ARTICLE 7 

TERM AND TERMINATION 

7.1    Term. This Agreement shall commence on the Effective Date and shall continue in full force and effect until
the earliest of (a) the date on which this Agreement is terminated in accordance with this Article 7; (b) the expiration of the last Service Period, such that AZ is no longer obligated to provide any Services pursuant to this Agreement; and
(c) the termination by Spinco of the only remaining outstanding Services pursuant to Section 7.2.1, such that AZ is no longer obligated to provide any Services pursuant to this Agreement (the “Transition Period”). For
purposes of this Agreement, the term “Service Period” shall mean, with respect to any particular Service, the period between the Effective Date and the termination date for the transition period as set forth in
Schedule 2.1 with respect to such Service. For clarity, all obligations of AZ to provide to Spinco any Services under this Agreement shall cease at the end of the Transition Period. 

7.2    Termination of Services. 

7.2.1    Spinco may, at any time prior to the end of the Transition Period and upon 30 days’ (or such longer period,
if any, specified in Schedule 2.1 for a particular Service) prior written notice to AZ, terminate this Agreement in its entirety or with respect to all or any Services, whereupon, from and after the date of termination specified in such
written notice, AZ’s obligation to provide such Services to Spinco shall cease and Spinco shall have no obligation to pay AZ for such Service(s) (other than with respect to those Services requested by Spinco, and performed by AZ or its
Affiliates or subcontractors, and costs incurred, or non-cancellable commitments made, prior to termination); provided that if termination of any Service materially inhibits AZ’s ability to provide
or prevents AZ from providing any other Services (as determined in AZ’s sole discretion), such other Services shall also shall be deemed terminated (provided, that AZ first notifies Spinco in writing of the Services that AZ would be
materially inhibited or prevented from providing due to such termination, and Spinco does not revoke such termination within [***] of receiving such notice from AZ). 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 7.2.2    In the event that either Party (the “Breaching
Party”) breaches any of its material obligations under this Agreement, the other Party may terminate this Agreement upon 30 days’ prior written notice (such 30-day period, the “Notice
Period”) to the Breaching Party, specifying the breach and its claim of right to terminate; provided, that the termination of this Agreement shall not become effective at the end of the Notice Period if (a) the Breaching Party
cures such breach during the Notice Period or (b) such breach cannot be cured during the Notice Period and the Breaching Party commences and diligently pursues actions to cure such breach within the Notice Period, in which case the Breaching
Party shall have an additional 30-day period to cure such breach before such termination shall become effective, provided, further, that a [***] cure period shall apply to any breach of a payment
obligation hereunder and such cure period shall not be subject to extension in accordance with the preceding proviso. 

7.2.3    Either Party may terminate this Agreement immediately upon written notice to the other Party if the other Party
(a) files in any court or with any other Governmental Authority, pursuant to any Law of any state or country, a petition in bankruptcy or insolvency or for reorganization or for an arrangement or for the appointment of a receiver or trustee of
that Party or of its assets; (b) proposes a written agreement of composition or extension of its debts; (c) is served with an involuntary petition against it, filed in any insolvency proceeding, and such petition is not dismissed within
[***] [***] after the filing thereof; (d) consents to the appointment or taking possession by a receiver, liquidator, assignee, custodian, trustee, sequestrator (or similar official) of such Party or for any substantial part of its property or
makes any assignment for the benefit of creditors; (e) admits in writing its inability to pay its debts generally as they become due; or (f) has issued or levied against its property any judgment, writ, warrant of attachment or execution
or similar process that represents a substantial portion of its property. 
 7.2.4    Either Party may terminate this
Agreement to the extent provided in Section 8.1. 
 7.2.5    This Agreement may be terminated upon the mutual
written agreement of Spinco and AZ at any time. 
 7.3    Accrued Rights; Surviving Obligations. 

7.3.1    Accrued Rights. Termination or expiration of this Agreement for any reason shall be without prejudice to
any rights that shall have accrued to the benefit of a Party prior to such termination or expiration. Such termination or expiration shall not relieve a Party from obligations that are expressly indicated to survive the termination or expiration of
this Agreement. 
 7.3.2    Surviving Obligations. Without limiting the foregoing, [***] shall survive the
termination or expiration of this Agreement for any reason. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 ARTICLE 8 

MISCELLANEOUS 

8.1    Force Majeure. Except for the obligation to pay amounts due and owing, neither Party shall be liable for any
failure to perform or any delays in performance, and no such Party shall be deemed to be in breach or default of its obligations set forth in this Agreement, if, to the extent and for so long as, such failure or delay is due to any causes that are
beyond its reasonable control and without its fault or negligence, including such causes as acts of God, natural disasters, fire, flood, severe storm, earthquake, civil disturbance, lockout, riot, order of any court or administrative body, embargo,
acts of government, war (whether or not declared), acts of terrorism, or other similar causes (“Force Majeure Event”). In the event of a Force Majeure Event, the Party prevented from or delayed in performing shall
promptly give notice to the other Party and shall use commercially reasonable efforts to avoid or minimize the delay. In the event that the delay continues for a period of at least 30 days, the Party affected by the other Party’s delay may
elect to (a) suspend performance and extend the time for performance for the duration of the Force Majeure Event, or (b) terminate this Agreement without any liability to either Party arising out of such termination. 

8.2    Independent Contractor. The Parties and each of their respective Affiliates shall each be an independent
contractor in the performance of its obligations hereunder. 
 8.3    Governing Law, Jurisdiction, Venue and
Service. 
 8.3.1    Governing Law. This Agreement shall be governed by and construed in accordance with the
Laws of the State of New York, excluding any conflicts or choice of Law rule or principle that might otherwise refer construction or interpretation of this Agreement to the substantive Law of another jurisdiction. 

8.3.2    Jurisdiction. The Parties hereby irrevocably and unconditionally consent to the exclusive jurisdiction of
the courts of the State of New York and the United States District Court for the Southern District of New York for any action, suit or proceeding (other than appeals therefrom) arising out of or relating to this Agreement, and agree not to commence
any action, suit or proceeding (other than appeals therefrom) related thereto except in such courts. The Parties irrevocably and unconditionally waive their right to a jury trial in connection with any litigation arising out of or relating to this
Agreement or the transactions contemplated hereby. 
 8.3.3    Venue. The Parties further hereby irrevocably and
unconditionally waive any objection to the laying of venue of any action, suit or proceeding (other than appeals therefrom) arising out of or relating to this Agreement in the courts of the State of New York or in the United States District Court
for the Southern District of New York, and hereby further irrevocably and unconditionally waive and agree not to plead or claim in any such court that any such action, suit or proceeding brought in any such court has been brought in an inconvenient
forum. 
 8.3.4    Service. Each Party further agrees that service of any process, summons, notice or document by
registered mail to its address set forth in Section 8.4.2 shall be effective service of process for any action, suit or proceeding brought against it under this Agreement in any such court. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 8.4    Notices. 

8.4.1    Notice Requirements. All notices or other communications which are required or permitted hereunder (each, a
“Notice”) shall be in writing and sufficient if delivered personally or sent by nationally recognized overnight courier or by registered or certified mail, postage prepaid, return receipt requested, or by facsimile or email,
addressed to the Parties at their respective addresses specified in Section 8.4.2 or to such other address as the Party to whom notice is to be given may have furnished to the other Party in writing in accordance herewith. All such notices and
other communications required or permitted by this Agreement shall be deemed to have been duly given (a) if sent to a recipient at the proper address as determined pursuant to this Section 8.4 by registered or certified mail, return
receipt requested, five calendar days after being deposited in the United States mail, postage prepaid; (b) if sent by Express Mail, Federal Express or similar reputable overnight delivery service that maintains records of receipt for next
Business Day delivery, the next Business Day after being entrusted to such service, with delivery charges prepaid or charged to the sender’s account; (c) if sent by facsimile transmission or email, on the date of transmission with
electronic confirmation of transmission; and (d) if delivered by hand, on the date of delivery. 
  

							
		  	8.4.2	  	Address for Notice.	  	
				
		  		  	If to AZ, to:	  	
				
		  		  	MedImmune, LLC	  	
		  		  	950 Wind River Lane	  	
		  		  	Gaithersburg, MD 20878	  	
		  		  	Attention: General Counsel	  	
			
		  		  	With a copy (which shall not constitute notice) to:
				
		  		  	[***]	  	
		  		  	[***]	  	
		  		  	[***]	  	
		  		  	[***]	  	
		  		  	[***]	  	
				
		  		  	If to Spinco, to:	  	
				
		  		  	Viela Bio, Inc.	  	
		  		  	1 Medimmune Way	  	
		  		  	Gaithersburg, MD 20878	  	
		  		  	Attention: Bing Yao	  	

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

							
		  		  	 With a copy (which shall not constitute notice) to:

 

		  		  	Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. 701 Pennsylvania Ave., NW, Suite 900
		  		  	Washington, DC 20004	  	
		  		  	Attention: Christopher Jeffers	  	

 8.5    No Benefit to Third Parties. The covenants and agreements set forth in this
Agreement are for the sole benefit of the Parties and their successors and permitted assigns, and, except for the rights of any indemnified Person under Article 6, they shall not be construed as conferring any rights on any other Persons. 

8.6    Waiver and Non-Exclusion of Remedies. Any term or condition of this
Agreement may be waived at any time by the Party that is entitled to the benefit thereof, but no such waiver shall be effective unless set forth in a written instrument duly executed by or on behalf of the Party waiving such term or condition. The
waiver by either Party of any right hereunder or of the failure to perform or of a breach by the other Party shall not be deemed a waiver of any other right hereunder or of any other breach or failure by said other Party whether of a similar nature
or otherwise. The rights and remedies provided herein are cumulative and do not exclude any other right or remedy provided by applicable Law or otherwise available except as expressly set forth herein. 

8.7    Assignment. 

8.7.1    Subject to the remainder of this Section 8.7, neither this Agreement nor either Party’s rights or
obligations hereunder may be assigned or delegated by such Party, directly or indirectly (by operation of Law or otherwise), without the prior written consent of the other Party; provided, however, that (a) AZ may assign or
delegate any or all of its rights or obligations hereunder to an Affiliate of AZ or to any successor in interest (whether by merger, acquisition, asset purchase or otherwise) to all or substantially all of the business to which this Agreement
relates, and may delegate any or all of its obligations hereunder to subcontractors, in each case, without the prior written consent of Spinco and (b) Spinco may assign its rights, interests, and obligations hereunder (in whole and not in part)
to a wholly owned Affiliate of Spinco without AZ’s prior written approval. 
 8.7.2    Following the earlier to
occur of (a) the consummation in full of the Milestone Closing (as defined in the Securities Purchase Agreement), and (b) the consummation of a Qualified IPO (as defined in the Restated Certificate (as defined in the Securities Purchase
Agreement)), Spinco may assign its applicable rights, interests, and obligations hereunder related to one or more Programs to a Third Party without AZ’s prior written approval, so long as (i) such assignment shall be in connection with the
divestment by Spinco of all or substantially all of the assets relating to such Program or Programs (whether by asset purchase or exclusive out-license), (ii) in connection therewith, Spinco also assigns to
such Third Party its applicable rights, interests, and obligations under the other Transaction Agreements related to such Program or Programs, and (iii) proper provision shall be made so that the successors and assigns of Spinco shall succeed
to Spinco’s applicable rights and obligations set forth herein and therein. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 8.7.3    If Spinco or any of its successors or assigns
(a) consolidates with or merges into any other Person and shall not be the continuing or surviving corporation or entity of such consolidation or merger or (b) transfers, licenses or conveys all or substantially all of its rights and
assets to any Person, then, and in each such case, Spinco may assign its rights, interests and obligations hereunder (in whole and not in part) to such Person without the prior written approval of AZ so long as in connection therewith Spinco
(i) also assigns to such Person all of its applicable rights, interests, and obligations under the other Transaction Agreements, and (ii) ensures that proper provision shall be made so that the successors and assigns of Spinco shall
succeed to Spinco’s rights and obligations set forth in this Agreement. 
 8.7.4    Notwithstanding anything to the
contrary set forth herein, no assignment or succession pursuant to this Section 8.7 shall relieve the assigning Party or predecessor Party of its obligations hereunder. Upon any permitted assignment, the references in this Agreement to a Party
shall also apply to any such assignee unless the context otherwise requires. 
 8.7.5    Subject to the remainder of
this Section 8.7, this Agreement shall be binding upon, inure to the benefit of, and be enforceable by, the Parties and their respective successors and permitted assigns. Any attempted assignment or transfer in violation of this
Section 8.7 shall be null and void. 
 8.7.6    Notwithstanding the foregoing, in the event a Party assigns its
rights or obligations under this Agreement or otherwise makes payments from a jurisdiction other than the jurisdiction in which such Party is organized (each, an “Assignment”), and immediately after such Assignment the amount of Tax
required to be withheld on any payment pursuant to this Agreement is greater than the amount of such Tax that would have been required to have been withheld absent such Assignment, then such increased withholding tax shall be borne by the Party
making such Assignment. 
 8.8    Amendment. Except as expressly provided herein, this Agreement may not be
modified, amended, altered or supplemented except upon the execution and delivery of a written agreement executed by both Parties. 

8.9    Severability. If any provision of this Agreement is held to be illegal, invalid or unenforceable under any
present or future Law, and if the rights or obligations of either Party under this Agreement will not be materially and adversely affected thereby, (a) such provision shall be fully severable, (b) this Agreement shall be construed and
enforced as if such illegal, invalid or unenforceable provision had never comprised a part hereof, (c) the remaining provisions of this Agreement shall remain in full force and effect and shall not be affected by the illegal, invalid or
unenforceable provision or by its severance herefrom and (d) in lieu of such illegal, invalid or unenforceable provision, there shall be added automatically as a part of this Agreement a legal, valid and enforceable provision as similar in
terms to such illegal, invalid or unenforceable provision as may be possible and reasonably acceptable to the Parties. 

8.10    English Language. This Agreement shall be written and executed in, and all other communications under or in
connection with this Agreement shall be in, the English language. Any translation into any other language shall not be an official version thereof, and in the event of any conflict in interpretation between the English version and such translation,
the English version shall control. 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 8.11    Counterparts. This Agreement may be executed in any
number of counterparts, and each such counterpart hereof shall be deemed to be an original instrument, but all such counterparts together shall constitute but one agreement. Delivery of an executed counterpart of a signature page of this Agreement
by facsimile or other electronic transmission shall be effective as delivery of a manually executed original counterpart of this Agreement. 

8.12    Entire Agreement. This Agreement, together with the APA, the Schedules and Exhibits expressly contemplated
hereby and attached hereto, the Disclosure Schedules, the other Transaction Agreements and the other agreements, certificates and documents delivered in connection with the APA or otherwise in connection with the transactions contemplated hereby and
thereby, contain the entire agreement between the Parties with respect to the transactions contemplated hereby or thereby and supersede all prior agreements, understandings, promises and representations, whether written or oral, between the Parties
with respect to the subject matter hereof and thereof. In the event of any inconsistency between any such Schedules and Exhibits and this Agreement, the terms of this Agreement shall govern. In the event of any inconsistency between this Agreement
and the other Transaction Agreements, the APA shall control, followed by the License Agreement (as defined in the APA). 
 [Signature page
follows] 

  
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(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 IN WITNESS WHEREOF, AZ and Spinco have duly executed this Agreement as of the date first
written above. 
  

			
	AZ:
	
	MEDIMMUNE, LLC
		
	By:	 	[***]
	Name:	 	[***]
	Title:	 	  

	
	SPINCO:
	
	VIELA BIO, INC.
		
	By:	 	 /s/ Zhengbin (Bing) Yao

	Name:	 	Zhengbin (Bing) Yao
	Title:	 	CEO

 [Signature Page to Transition Services Agreement] 

  
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INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE THE INFORMATION (I) IS NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

 Schedule 2.1 

[***] 

  
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