Document:

Employment Agreement, between the Registrant and John C. Doyle

 Exhibit 10.10 
  
 R  E  N  O  V  I  S    R E
S O L V I N G    B R A I N    C O M P L E X I T Y 
  
 July 23, 2002 
  
 John C. Doyle 
  
 Re: Employment Terms 
  
 Dear John: 
  
 I am extremely pleased to offer you the position of Chief Financial Officer. I look forward to your favorable reply. Please review the following employment terms:

  
 You will be responsible for working as Chief Financial Officer and will report
directly to me, CEO. You will work at our facility located at 270 Littlefield, South San Francisco, CA. Of course, Renovis may change your position, reporting structure, duties, and work location from time to time as it deems necessary. 

 
 Your compensation will be $190,000 per year, less payroll deductions and all required
withholdings. You will also be eligible for an annual bonus of up to 30% of base salary. As of your start date of August 7, 2002, you will be paid $7,916.67 before taxes and other deductions, semi-monthly on the fifteenth and last date of every
month. In addition, you will be granted an option to purchase 225,000 shares of the company’s common stock, as governed by the terms of the Company’s stock option plan, at a price to be determined by and subject to approval of the
Company’s Board of Directors. Your stock options will vest at a rate of 56,250 shares as of the first anniversary of your start date and 4,687.5 shares per calendar month thereafter. 
  
 You will also be eligible for the following standard Company benefits: medical insurance, vacation, 401(k) plan, sick leave, and holidays.
Details about these benefit plans are available for your review; however, please note that Renovis may modify compensation and benefits from time to time as it deems necessary. 
  
 As a Renovis employee, you will be expected to abide by Company rules and policies, acknowledge in writing that you have read the
Company’s Employee Handbook, and sign and comply with the attached Proprietary Information and Inventions Agreement which prohibits unauthorized use or disclosure of Renovis proprietary information. 
  
 In your work for the Company, you will be expected not to use or disclose any confidential
information, including trade secrets, of any former employer or other person to whom you have an obligation of confidentiality. Rather, you will be expected to use only that information which is generally known and used by persons with training and
experience comparable to your own, which is common knowledge in the industry or otherwise legally in the public domain, or which is otherwise provided or developed by the Company. During our discussions about your proposed job duties, you assured us
that you would be able to perform those duties within the guidelines just described. 
  
 RENOVIS, INC. Ÿ 270 Littlefield
Avenue, S. San Franciso, CA 94080 Ÿ Tel : 650.266.1400 Ÿ Fax 650.266.1460 Ÿ www renovis.com 

 John C. Doyle 
 July 23, 2002

 Page 2 
  
 You agree that you will not bring onto Company premises any unpublished documents or property belonging to any former employer or other person to whom you have an obligation of confidentiality. 
  
 Normal business hours are from 8:30 a.m. to 5:30 p.m., Monday through Friday. As an exempt
salaried employee, you will be expected to work additional hours as required by the nature of your work assignments. 
  
 You may terminate your employment with Renovis at any time and for any reason whatsoever simply by notifying Renovis. Likewise, Renovis may terminate your employment at
any time and for any reason whatsoever, with or without cause or advance notice. This at-will employment relationship cannot be changed except in writing signed by a Company officer. 
  
 This letter, together with your Proprietary Information and Inventions Agreement, forms the complete and exclusive statement of your
employment agreement with Renovis. The employment terms in this letter supersede any other agreements or promises made to you by anyone, whether oral or written. As required by law, this offer is subject to satisfactory proof of your right to work
in the United States. 
  
 Please sign and date this letter, and return it to me by
July 25, 2002, if you wish to accept employment at Renovis under the terms described above. 
  
 I want you to know how enthusiastic we are to have you on the Renovis team. It’s a great opportunity for Renovis and a great opportunity for you. We look forward to working with you. I look forward to speaking
with you soon! 
  

	 Sincerely,

	
	 /s/    Corey
Goodman        

	 Corey Goodman, Ph.D.

	 President & Chief Executive Officer

  

	 Accepted

	
	 /s/    John C.
Doyle        

	
	                         8/5/02

	 Date

  
 Attachments: Proprietary Information
and Inventions AgreementAmendment to Employment Agreement, btwn the Registrant and John C. Doyle

 Exhibit 10.11 
  
 R  E  N  O  V  I  S 
 R E N E W . R E S T O R E . R E P A I R 
  
 May 1, 2003 
  
 John Doyle 
  
 Re: Amendment to Renovis, Inc.
Offer Letter 
  
 Dear John: 
  
 You and Renovis, Inc. (the “Company”) are parties to an offer letter dated July
23, 2002 (the “Offer Letter”), which sets forth, among other things, the terms of your employment with the Company. The Company would like to amend the Offer Letter as provided below to provide you with certain severance benefits in the
event of a termination of your employment without Cause (as defined below) or your Constructive Termination (as defined below). This letter agreement supersedes any other agreement or policy to which the Company is a party with respect to any
severance benefits payable to you and any acceleration of vesting of your stock options or restricted stock as a result of your termination of employment. 
  
 1. Severance Benefits. 
  
 (a) Termination By The Company Without Cause. If your employment by the Company is terminated by the Company without Cause (as defined below), or
if there is a Constructive Termination (as defined below), at any time prior to the occurrence of a Change in Control or more than thirteen (13) months following the occurrence of a Change in Control, and if you provide the Company with a signed
general release of all claims, a form of which is set forth in Exhibit A hereto, the Company shall provide you with the following severance benefits: (1) continuation of your base salary for a period of six (6) months after your termination date at
the rate in effect immediately prior to your termination of employment, less applicable withholdings, payable in installments pursuant to the Company’s normal and customary payroll procedures; (2) for the period beginning on your date of
termination and ending on the date which is six (6) full months following your date of termination (or, if earlier, the date on which you accept employment with another employer that provides comparable benefits), the Company shall pay for and
provide you and your dependents with the same health benefits (e.g., medical and dental) to which you would have been entitled had you remained continuously employed by the Company during such period, including, if necessary, paying the costs
associated with continuation coverage pursuant to the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”); and (3) on your date of termination, you shall immediately become vested with respect to those options to
purchase the Company’s capital stock that you then hold that would have vested during the six (6) month period following your date of termination and/or any restrictions with respect to restricted shares of the Company’s capital stock that
you then hold that would have vested during the six (6) month period following your date of termination shall immediately lapse. 
  
 RENOVIS, INC Ÿ 270 Liitlefield
Avenue, S. San Francisco, CA 94080 Ÿ Tel: 650.266.1400 Ÿ Fax: 650.266.1460 Ÿ www.renovis.com 

 You understand and agree that you shall not be entitled to any other severance pay, severance benefits, or any other
compensation or benefits other than as set forth in this paragraph in the event of such a termination, other than as required under applicable law. 
  
 (b) Termination By The Company With Cause Or Termination By You. If your employment by the Company is terminated by the Company with
Cause, or if you voluntarily terminate your employment with the Company (other than pursuant to a Constructive Termination (as defined below)), you shall not be entitled to any severance pay, severance benefits, or any compensation or benefits from
the Company whatsoever, other than as required under applicable law. 
  
 (c) Termination Following Change in Control. If your employment by the Company is terminated by the Company without Cause (as defined below), or if there is a Constructive Termination (as defined below),
in each case at any time within thirteen (13) months following the occurrence of a Change in Control, and if you provide the Company with a signed general release of all claims, a form of which is set forth in Exhibit A hereto, the Company shall
provide you with the following severance benefits: (1) a lump sum payment equal to twelve (12) months of your base salary at the rate in effect immediately prior to the Change in Control, less applicable withholdings, to be paid by the Company
within ten (10) days of your date of termination; (2) for the period beginning on your date of termination and ending on the date which is twelve (12) full months following your date of termination (or, if earlier, the date on which you accept
employment with another employer that provides comparable benefits), the Company shall pay for and provide you and your dependents with the same health benefits (e.g., medical and dental) to which you would have been entitled had you remained
continuously employed by the Company during such period, including, if necessary, paying the costs associated with continuation coverage pursuant to COBRA; and (3) on your date of termination, you shall immediately become 100% vested with respect to
any options to purchase the Company’s capital stock that you then hold and/or any restrictions with respect to restricted shares of the Company’s capital stock that you then hold shall immediately lapse, and you shall be entitled to
exercise any such vested options until the expiration date of such options set forth in the stock option agreement(s) pursuant to which they were granted; provided, however, that if you are terminated by the Company following the effective
date of a Change in Control described in clause (d)(2)(b) below but accept employment with the Company’s successor or acquirer within thirty (30) days after the effective date of the Change in Control on terms and conditions not less favorable
to you than those contained in the Offer Letter (as amended by this letter agreement), you shall not be entitled to any severance benefits under this clause (c); provided, further, however, that if your employment is thereafter terminated by
the successor or acquiror without Cause (as defined below), or if there is a Constructive Termination (as defined below), at any time within thirteen (13) months following the occurrence of the Change in Control, you shall be entitled to the
severance benefits described above in this clause (c). 

 You understand and agree that you shall not be entitled to any other severance pay, severance benefits, or any other
compensation or benefits other than as set forth in this paragraph in the event of such a termination, other than as required under applicable law. 
  
 (d) Definitions. 
  
 (1) Cause. For purposes of this letter agreement, the term “Cause” means: (i) theft, dishonesty or falsification of any employment
or Company records; (ii) malicious or reckless disclosure of the Company’s confidential or proprietary information; (iii) commission of any immoral or illegal act or any gross or willful misconduct, where the Company reasonably determines that
such act or misconduct has (A) seriously undermined the ability of the Company’s management to entrust you with important matters or otherwise work effectively with you, (B) contributed to the Company’s loss of significant revenues or
business opportunities, or (C) significantly and detrimentally effected the business or reputation of the Company or any of its subsidiaries; and/or (iv) the failure or refusal by you to work diligently to perform tasks or achieve goals reasonably
requested by the Board, provided such failure or refusal continues after the receipt of reasonable notice in writing of such failure or refusal and an opportunity to correct the problem. “Cause” shall not mean a physical or mental
disability. 
  
 (2) Change in Control. For purposes
of this letter agreement, the term “Change in Control” means the consummation of any of the following transactions: 
  
 a. the closing of a business combination (such as a merger or consolidation) of the Company with any other corporation or other type of business
entity (such as a limited liability company), other than a business combination which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being
converted into voting securities of the surviving entity) at least fifty percent (50%) of the total voting power represented by the voting securities of the Company or such controlling surviving entity outstanding immediately after such business
combination; or 
  
 b. the sale, lease, exchange or other
transfer or disposition by the Company of all or substantially all (more than seventy percent (70%)) of the Company’s assets by value; or 
  
 c. an acquisition of any voting securities of the Company by any “person” (as the term “person” is used for purposes of
Section 13(d) or Section 14(d) of the Securities Exchange Act of 1934, as amended (the “1934 Act”)) immediately after which such person has “beneficial ownership” (within the meaning of Rule 13d-3 promulgated under the 1934 Act)
of fifty percent (50%) or more of the combined voting power of the Company’s then outstanding voting securities. 

 (3) Constructive Termination. For purposes of this letter agreement, the term “Constructive
Termination” means your resignation within sixty (60) days of one or more of the following events which remains uncured thirty (30) days after your delivery of written notice thereof: 
  
 a. the delegation to you of duties or the reduction of your duties,
either of which substantially reduces the nature, responsibility, or character of your position immediately prior to such delegation or reduction; 
  
 b. a material reduction by the Company in your base salary in effect immediately prior to such reduction; 
  
 c. a material reduction by the Company in the kind or level of
employee benefits or fringe benefits to which you were entitled prior to such reduction; or the taking of any action by the Company that would adversely affect your participation in any plan, program or policy generally applicable to employees of
equivalent seniority; and 
  
 d. the Company’s
requiring you to relocate your office to a place more than forty (40) miles from its present location (except that required travel on the Company’s business to an extent substantially consistent with your present business travel obligations
shall not be considered a relocation). 
  
 2. Effect of Amendment. Except
as specifically amended above, the Offer Letter shall remain in full force and effect and is hereby ratified and confirmed. 
  
 3. Entire Agreement. This letter agreement and Exhibit A hereto, together with the Offer Letter, constitute the entire agreement between you and the Company
relating to the terms and conditions of your employment specified herein and therein. 
  
 If the terms of this letter agreement are acceptable to you, please sign below and return this letter to Paula Serbin 
  

	 Very truly yours,

	
	Renovis, Inc.
	
	 /s/    Corey
Goodman        

	 Corey Goodman, Ph.D.

	 President and Chief Executive Officer

  

	 Accepted and Agreed to by:

	
	 /s/    John
Doyle        

	 John Doyle

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