Document:

EX-10.13

 Exhibit 10.13 

SINGULAR GENOMICS SYSTEMS, INC. 

MANAGEMENT CASH INCENTIVE PLAN 

ARTICLE 1. BACKGROUND AND PURPOSE 

1.1    Effective Date. This Plan became effective upon its adoption by the Committee and is not subject to approval
by the Company’s stockholders. 
 1.2    Purpose of the Plan. The Plan is intended to provide Participants
with the possibility of earning incentive bonuses. 
 ARTICLE 2. DEFINITIONS 

The following words and phrases shall have the following meanings, unless a different meaning is plainly required by the context: 

2.1    “Actual Award” means, as to any Performance Period, the actual award amount (if any) payable to a
Participant for the Performance Period. Each Actual Award is determined by the Payout Formula for the Performance Period, subject to the Administrator’s authority under Section 3.6 to increase, eliminate or reduce the award otherwise
indicated by the Payout Formula. 
 2.2    “Administrator” means the Board, Committee or such other
entity, group, or individual delegated authority to administer the Plan in accordance with Section 5.1 of the Plan. 

2.3    “Affiliate” means any corporation or other entity (including, without limitation, partnerships and
joint ventures) controlled by the Company. 
 2.4    “Base Salary” means, as to any Performance Period,
the Participant’s regular base salary as in effect at the end of the Performance Period. Base Salary shall be calculated before both (a) deductions for taxes or benefits and (b) any deferrals of compensation pursuant to
Company-sponsored plans or Affiliate-sponsored plans. 
 2.5    “Board” means the Company’s Board
of Directors. 
 2.6    “Change in Control” means (a) a sale, conveyance or other disposition of
all or substantially all of the assets, property or business of the Company, except where such sale, conveyance or other disposition is to a wholly owned subsidiary of the Company, (b) a merger or consolidation of the Company with or into
another corporation, entity or person, other than any such transaction in which the holders of voting capital stock of the Company outstanding immediately prior to the transaction continue to hold a majority of the voting capital stock of the
Company (or the surviving or acquiring entity) outstanding immediately after the transaction (taking into account only stock of the Company held by such stockholders immediately prior to the transaction and stock issued on account of such stock in
the transaction), or (c) the direct or indirect acquisition (including by way of a tender or exchange offer) by any person, or persons acting as a group, of beneficial ownership or a right to acquire beneficial ownership of shares

 
representing a majority of the voting power of the then outstanding shares of capital stock of the Company; provided, however, that a Change of Control shall not include any transaction or series
of related transactions (1) principally for bona fide equity financing purposes or (2) effected exclusively for the purpose of changing the domicile of the Company. A series of related transactions shall be deemed to constitute a single
transaction for purposes of determining whether a Change of Control has occurred. 
 2.7    “Committee”
means the Compensation Committee of the Board. 
 2.8    “Company” means Singular Genomics Systems,
Inc., a Delaware corporation, or any successor thereto. 
 2.9    “Employee” means any employee of the
Company or of an Affiliate, whether such employee is so employed when the Plan is adopted or becomes so employed after the adoption of the Plan. 

2.10    “Executive” means any executive officers as defined under Rule
3b-7 and officer as defined under Rule 16a-f promulgated under Section 16 of the Securities and Exchange Act. 

2.11    “Fiscal Year” means the fiscal year of the Company. 

2.12    “Participant” means, as to any Performance Period, an Employee who has been selected for
participation in the Plan for that Performance Period pursuant to Section 3.1. 
 2.13    “Payout
Formula” means, as to any Performance Period, the formula or payout matrix established by the Administrator pursuant to Section 3.5 in order to determine the Actual Awards (if any) to be paid to Participants. The formula or matrix may
differ from Performance Period to Performance Period and from Participant to Participant. 

2.14    “Performance Period” means a Fiscal Year, or any longer or shorter period determined by the
Administrator. 
 2.15    “Performance Goals” means the goal(s) or combined goal(s) determined by the
Administrator to be applicable to a Participant for a Target Award for a Performance Period. As determined by the Administrator, the Performance Goal(s) may provide for a targeted level or levels or achievement using the performance criteria
specified by the Administrator. Possible, but non-exclusive, performance criteria are set forth in Appendix A attached to the Plan. 

2.16    “Plan” means this Singular Genomics Systems, Inc. Management Cash Incentive Plan, as amended from
time to time. 
 2.17    “Shares” means shares of the Company’s common stock. 

2.18    “Target Award” means the target award amount payable under the Plan to a Participant for the
Performance Period expressed as a percentage of his or her Base Salary or a specific dollar amount or by reference to a number of Shares, as determined by the Administrator in accordance with Section 3.4. 

 2.19    “Termination of Employment” means a cessation
of the employee-employer relationship between an Employee and the Company or an Affiliate for any reason, including (without limitation) a termination by resignation, discharge, death, disability, retirement or the disaffiliation of an Affiliate,
but excluding a transfer from the Company to an Affiliate or between Affiliates. 
 ARTICLE 3. SELECTION OF PARTICIPANTS AND
DETERMINATION OF AWARDS 
 3.1    Selection of Participants. The Administrator, in its sole discretion, shall
select the Employees who shall be Participants for any Performance Period. Participation in the Plan is in the sole discretion of the Administrator and shall be determined Performance Period by Performance Period. Accordingly, an Employee who is a
Participant for a given Performance Period is in no way assured of being selected for participation in any subsequent Performance Period. 

3.2    Determination of Performance Period. The Administrator, in its sole discretion, shall establish whether a
Performance Period shall be a Fiscal Year or such longer or shorter period of time. The Performance Period may differ from Participant to Participant and from award to award. 

3.3    Determination of Performance Goals. The Administrator shall establish the Performance Goals for each
Participant for the Performance Period, and the Administrator (or its designee) shall communicate the applicable Performance Goals to each Participant. The Performance Goals may differ from Participant to Participant and from award to award. 

3.4    Determination of Target Awards. The Administrator shall establish a Target Award for each Participant for
each Performance Period, and the Administrator (or its designee) shall communicate the applicable Target Award to each Participant. 

3.5    Determination of Payout Formula or Formulae. The Administrator will establish a Payout Formula or Formulae
for purposes of determining the Actual Award (if any) payable to each Participant. Each Payout Formula may (a) be based on a comparison of actual performance to the Performance Goals, (b) provide for the payment of a Participant’s
Target Award if the Performance Goals for the Performance Period are achieved at the predetermined level and (c) provide for the payment of an Actual Award greater than or less than the Participant’s Target Award, depending upon the extent
to which actual performance exceeds or falls below the Performance Goals, subject to the limitations in Section 3.7. 

3.6    Determination of Actual Awards. After the end of each Performance Period, the Administrator will determine
the extent to which the Performance Goals applicable to each Participant for the Performance Period were achieved or exceeded. The Actual Award for each Participant will be determined by applying the Payout Formula to the level of actual performance
that has been determined by the Administrator; provided that notwithstanding anything to the contrary in this Plan, the Administrator may (a) reduce or eliminate the Actual Award that otherwise would be payable under the Payout Formula;
(b) increase the Actual Award; or (c) determine whether or not any Participant will receive an Actual Award in the event that the 

 
Participant incurs a Termination of Employment before such Actual Award is to be paid pursuant to Section 4.1. If a Participant’s Actual Award is reduced or eliminated, no other
Participant’s Actual Award shall be increased as a result. The Administrator has the absolute discretion to reduce or eliminate payment of an Actual Award if in the Administrator’s judgment corporate performance, financial condition,
individual performance, general economic conditions, or other similar factors make such reduction or elimination appropriate. 

3.7    Maximum Actual Awards. The Administrator may establish the maximum amount or value of the Actual Award paid
to any Participant for any Performance Period. 
 ARTICLE 4. PAYMENT OF AWARDS  

4.1    Right to Receive Payment. A Participant shall have no right to receive an Actual Award unless the Participant
is employed by the Company or an Affiliate on the date of payment, unless otherwise determined by the Administrator. 

4.2    Unfunded Plan. Each Actual Award that may become payable under the Plan shall be paid solely from the
general assets of the Company or the Affiliate that employs the Participant (as the case may be), as determined by the Company. No amounts awarded or accrued under the Plan shall be funded, set aside or otherwise segregated prior to payment. The
obligation to pay Actual Awards under the Plan shall at all times be an unfunded and unsecured obligation of the Company. Participants shall have the status of general creditors of the Company or the Affiliate that employs the Participant. 

4.3    Timing of Payment. Subject to Sections 3.7 and 4.6, payment of each Actual Award shall be made as soon
as administratively practicable after the end of the applicable Performance Period, but in any event no later than required to ensure that that no amount paid or to be paid hereunder shall be subject to the provisions of Section 409A(a)(1)(B)
of the Code. 
 4.4    Form of Payment. Each Actual Award shall be paid in cash (or its equivalent) or in
Share-based awards (or a combination thereof) in a single lump sum, except as otherwise determined by the Administrator.    To the extent an Actual Award is paid in whole or in part in the form of Share-based awards, such awards
shall be granted under an equity incentive plan maintained by the Company for the payment or awarding of Shares. 

4.5    Payment in the Event of Death. If a Participant dies before receiving an Actual Award that was scheduled to
be paid before his or her death for a prior Performance Period, then the Actual Award shall be paid to the Participant’s designated beneficiary or, if no beneficiary has been designated, to the administrator or representative of his or her
estate, subject to applicable law. Any beneficiary designation or revocation of a prior designation shall be effective only if it is in writing, signed by the Participant and received by the Company prior to the Participant’s death, subject to
applicable law. 
 4.6    Recoupment Policy. All awards granted under the Plan shall be subject to any Company
recoupment or clawback policy, as in effect from time to time, including any required by Section 954 of the Dodd-Frank Wall Street Reform and Consumer Protection Act. 

 ARTICLE 5. ADMINISTRATION 

5.1    Administrator Authority. The Plan shall be administered by the Administrator, subject to Section 5.3;
provided, however, that with respect to any Executive, the Committee shall act as Administrator. The Administrator shall have all powers and discretion necessary or appropriate to administer the Plan and to control its operation, including
(without limitation) the power to (a) determine which Employees shall be granted awards, (b) prescribe the terms and conditions of the awards, (c) interpret the Plan, (d) adopt such procedures and
sub-plans as are necessary or appropriate, (e) adopt rules for the administration, interpretation and application of the Plan and (f) interpret, amend or revoke any such rules. 

5.2    Decisions Binding. All determinations and decisions made by the Administrator, the Board or any delegate of
the Administrator pursuant to the provisions of the Plan shall be final, conclusive and binding on all persons and shall be given the maximum deference permitted by law. 

5.3    Delegation by the Administrator. The Administrator, on such terms and conditions as it may provide, may
delegate all or part of its authority and powers under the Plan to one or more directors and/or employees of the Company, except that the Committee may not delegate its authority and powers under the Plan with respect to Executives. 

 ARTICLE 6. GENERAL PROVISIONS 

6.1    Tax Withholding. The Company or an Affiliate, as applicable, shall withhold all required taxes from an Actual
Award, including any federal, state, local or other taxes. 
 6.2    Application of Section 409A. The
provisions of this Plan are intended to be exempt from the requirements of Section 409A of the Code so that none of the payments to be provided under this Plan will be subject to the additional tax imposed under Section 409A of the Code,
and any ambiguities herein will be interpreted to be so exempt. In no event will the Administrator reimburse Participants for any taxes that may be imposed as result of Section 409A of the Code. 

6.3    No Effect on Employment. Neither the Plan nor any Target Award shall confer upon a Participant any right
with respect to continuing the Participant’s employment with the Company or an Affiliate.    Nothing in the Plan shall interfere with or limit in any way the right of the Company or an Affiliate, as applicable, to terminate
any Participant’s employment or service at any time, with or without cause. The Company and its Affiliates expressly reserve the right, which may be exercised at any time and without regard to when during or after a Performance Period such
exercise occurs, to terminate any individual’s employment with or without cause, and to treat him or her without regard to the effect that such treatment might have upon him or her as a Participant. 

6.4    Participation; No Effect on Other Benefits. No Employee shall have the right to be selected to receive an
award under the Plan, or, having been so selected, to be selected to receive a future award.    Except as expressly set forth in a Participant’s employment agreement with the Company or an Affiliate, any Actual Awards under
the Plan shall not be considered for the purpose of calculating any other benefits to which such Participant may be entitled, including 

 
(a) any termination, severance, redundancy or end-of-service payments, (b) other bonuses or long-service
awards, (c) overtime premiums, (d) pension or retirement benefits or (e) future Base Salary or any other payment to be made by the Company to such Participant. All Participants expressly acknowledge that there is no obligation on the
part of the Company to continue the Plan. Any Actual Awards granted under the Plan are not intended to be compensation of a continuing or recurring nature, or part of a Participant’s normal or expected compensation, 

6.5    Successors. All obligations of the Company and any Affiliate under the Plan, with respect to awards granted
hereunder, shall be binding on any successor to the Company and/or such Affiliate, whether the existence of such successor is the result of a merger, consolidation, direct or indirect purchase of all or substantially all of the business or assets of
the Company or such Affiliate, or any similar transaction. 
 6.6    Nontransferability of Awards. No award
granted under the Plan shall be sold, transferred, pledged, assigned or otherwise alienated or hypothecated, other than by will, by the laws of descent and distribution or to the limited extent provided in Section 4.5. All rights with respect
to an award granted to a Participant shall be available during his or her lifetime only to the Participant. 
 ARTICLE 7. DURATION,
AMENDMENT AND TERMINATION 
 7.1    Duration of the Plan. The Plan shall remain in effect until terminated
pursuant to Section 7.2. 
 7.2    Amendment, Suspension or Termination. The Board or the Administrator may
amend, suspend or terminate the Plan, or any part thereof, at any time and for any reason; provided that this Plan may not be suspended or terminated, nor amended in a manner adverse to a Participant for a period of twelve (12) months
following a Change in Control of the Company. No award may be granted during any period of suspension or after termination of the Plan.  

ARTICLE 8. LEGAL CONSTRUCTION  

8.1    Severability. In the event any provision of the Plan shall be held illegal or invalid for any reason, the
illegality or invalidity shall not affect the remaining parts of the Plan, and the Plan shall be construed and enforced as if the illegal or invalid provision had not been included. 

8.2    Requirements of Law. The granting of awards under the Plan shall be subject to all applicable laws, rules
and regulations, and to such approvals by any governmental agencies or national securities markets as may be required. 

8.3    Captions. Captions are provided herein for convenience only and shall not serve as a basis for
interpretation or construction of the Plan. 

 APPENDIX A 

PERFORMANCE METRICS 
 The Administrator
may establish Performance Goals derived from the following metrics, or from such other measures of performance selected by the Administrator from time to time: 

Industry-Specific 
  

	 	•	 	 regulatory achievements 

 

	 	•	 	 launch of new products 

 

	 	•	 	 market share 

  

	 	•	 	 pricing and/or reimbursement approval 

 

	 	•	 	 revenue, revenue growth or product revenue growth 

 

	 	•	 	 acquisitions of assets or intellectual property 

 

	 	•	 	 strategic partnerships or transactions (including in-licensing and out-licensing of intellectual property, whether in a particular jurisdiction or territory or globally or through partnering transactions) 

 

	 	•	 	 establishing relationships with commercial entities with respect to the marketing, distribution and sale of the
Company’s products (including with group purchasing organizations, distributors and other vendors) 

  

	 	•	 	 sales or licenses of the Company’s assets, including its intellectual property 

Financial 
  

	 	•	 	 appreciation in and/or maintenance of any publicly-traded securities of the Company 

 

	 	•	 	 cash flow, cash balance or cash flow per share (before or after dividends) 

 

	 	•	 	 cash flow return on investment 

 

	 	•	 	 cash margin 

  

	 	•	 	 comparisons with various stock market indices 

 

	 	•	 	 debt reduction 

  

	 	•	 	 earnings or loss per share 

 

	 	•	 	 earnings or losses (including earnings or losses before taxes, before interest and taxes, or before interest,
taxes, depreciation and amortization) 

  

	 	•	 	 economic value added (or an equivalent metric) 

 

	 	•	 	 expense or cost reduction 

 

	 	•	 	 financial ratios, including those measuring liquidity, activity, profitability or leverage 

 

	 	•	 	 financing and other capital raising transactions (including sales of the Company’s equity or debt
securities) 

  

	 	•	 	 gross margin 

  

	 	•	 	 gross profits 

  

	 	•	 	 improvement in or attainment of expense levels or working capital levels, including cash, inventory and accounts
receivable 

  

	 	•	 	 net income or loss (before or after taxes) 

	 	•	 	 net operating income or profits, before or after tax 

 

	 	•	 	 net sales 

  

	 	•	 	 operating cash flow or other operating efficiencies 

 

	 	•	 	 operating income (before or after taxes) 

 

	 	•	 	 operating margin 

  

	 	•	 	 total stockholder return 

 

	 	•	 	 working capital 

  

	 	•	 	 year-end cash 

 

	 	•	 	 share price 

  

	 	•	 	 stockholders’ equity 

 

	 	•	 	 reductions in costs 

  

	 	•	 	 return on assets, net assets, investment or capital employed (including return on total capital or return on
invested capital) 

  

	 	•	 	 return on equity or average stockholders’ equity 

 

	 	•	 	 return on operating revenue 

Organizational 
  

	 	•	 	 employee satisfaction 

  

	 	•	 	 employee survey results 

 

	 	•	 	 recruiting and maintaining personnel 

Performance Goals may be based solely by reference to the Company’s performance or the performance of a subsidiary, division, business segment or
business unit of the Company, or based upon the relative performance of other companies or upon comparisons of any of the indicators of performance relative to other companies. 

The Administrator may adjust the results under any performance criterion to exclude any of the following events that occurs during a performance measurement
period: (a) asset write-downs, (b) litigation, claims, judgments or settlements, (c) the effect of changes in tax law, accounting principles or other such laws or provisions affecting reported results, (d) accruals for
reorganization and restructuring programs, (e) any extraordinary, unusual or non-recurring items, (f) exchange rate effects for non-U.S. dollar denominated net
sales and operating earnings or (g) statutory adjustments to corporate tax rates. 
 Any Performance Goal used may be measured (a) in absolute
terms, (b) in relative terms, including (without limitation) the passage of time and/or against other companies or metrics, (c) on a per-share basis, (d) against the performance of the Company
as a whole or against particular segments or products of the Company and/or (e) on a pre-tax or after-tax basis. Any Performance Goal may be measured on a basis
other than generally accepted accounting principles.EX-10.14

 Exhibit 10.14 

SINGULAR GENOMICS SYSTEMS, INC. 

EXECUTIVE SEVERANCE PLAN 

1.    Purpose of the Plan 

The purpose of the Plan is to provide for the payment of severance benefits to certain eligible employees of the Company in the event such
employees are subject to certain qualifying employment terminations. This Plan shall supersede any and all prior separation, severance and salary continuation arrangements, programs and plans that were previously offered by the Company, either
orally or in writing, for which a Participant was eligible. Capitalized terms used in the Plan are defined in Section 11, except as otherwise specified. 

2.    Effective Date 

The Plan shall become effective on the closing date of the Company’s sale of its common stock in a firm commitment underwritten public
offering pursuant to a registration statement on Form S-1 under the Securities Act of 1933, as amended (the “Effective Date”). 

3.    Administration 

The Committee shall act as the plan administrator of the Plan and shall have the exclusive discretion and authority to establish rules, forms,
and procedures for the administration of the Plan and to construe and interpret the Plan and to decide any and all questions of fact, interpretation, definition, computation or administration arising in connection with the operation of the Plan,
including, but not limited to, the eligibility to participate in the Plan and amount of benefits paid under the Plan. The rules, interpretations, computations and other actions of the Committee as plan administrator of the Plan shall be binding and
conclusive on all persons. The Committee may act under the Plan on a case-by-case basis and the Committee’s decisions under the Plan need not be uniform with
respect to similarly situated Participants. 
 4.    Participation 

Eligibility under the Plan is limited to those Company executive employees and other key employees as are designated by the Committee from time
to time to participate in the Plan. 
 5.    Severance Benefits 

(a)    Termination not in Connection with a Change in Control. Subject to the terms of the Plan, if a
Participant is subject to an Involuntary Termination, then the Participant will be entitled to receive such Participant’s Accrued Benefits (if any) and, subject to the Participant’s satisfaction of the requirements of Section 6, the
Company shall provide the Participant with the following Severance Benefits: 
 (i)    Cash Severance.
The Company shall pay the Participant a lump-sum cash severance amount, as follows: 
  

			
	 Participant Tier
	  	 Cash Severance Amount

	Tiers 1 & 2	  	An amount equal to (i) 12 months of the Participant’s Base Salary and (ii) a Pro-Rata Bonus
		
	Tier 3	  	An amount equal to (i) 6 months of the Participant’s Base Salary and (ii) a Pro-Rata Bonus

 Any cash severance payable under this Section 5(a)(i) shall be paid in a lump sum on the first regular
payroll period following the expiration of any period during which the Participant may revoke the Release pursuant to Section 6, so long as the Release becomes effective no later than sixty (60) days after the Participant’s
Separation. Notwithstanding the foregoing, if the period during which a Participant has discretion to execute or revoke the Release straddles two taxable years, then the Company shall make any severance payment due to the Participant under this
Section 5(a)(i) in the second of such taxable years, regardless of which taxable year the Participant actually delivers the executed Release to the Company. 

(ii)    Accelerated Vesting of Equity Awards. Effective as of the date of the Participant’s
Separation, the Participant shall become vested in that portion of his or her then-outstanding and unvested time-based equity awards which would have otherwise become vested pursuant to their regular vesting schedule during the applicable period set
forth in the table below: 
  

			
	 Participant Tier
	  	 Vesting Period

	Tiers 1 & 2	  	12 months
		
	Tier 3	  	6 months

 Notwithstanding the foregoing, if the terms of an Existing Equity Award (excluding any such terms triggered by a termination
related to or in connection with a Change in Control) held by a Participant provides for more favorable vesting in the event of an Involuntary Termination than the vesting terms set forth in this Section 5(a)(ii), the terms of such Existing
Equity Award shall govern the accelerated vesting of such Existing Equity Award upon the Participant’s Involuntary Termination. 

(iii)    Health Benefit Continuation. If (x) the Participant was a participant in the Company’s
group health insurance plans on the date of such Participant’s Involuntary Termination and (y) timely elects continued coverage under COBRA, the Company shall pay the Employer’s portion of the Participant’s COBRA premiums on
behalf of the Participant and the Participant’s eligible dependents, until the earliest to occur of (A) the end of the number of months set forth in the table below for the Participant, as applicable, (B) the expiration of the
Participant’s eligibility for the continuation coverage under COBRA, and (C) the date when the Participant becomes eligible for substantially equivalent health insurance coverage in connection with new employment or self-employment (such
period from the Involuntary Termination through the earliest to occur of the dates set forth in clause (A) through (C), the “Non-CIC COBRA Payment Period”). 

 

			
	 Participant Tier
	  	 Health Benefit Continuation
Period

	Tiers 1 & 2	  	12 months
		
	Tier 3	  	6 months

  
 2 

 These payments will be subject to applicable tax withholdings, including as necessary to avoid a violation
of, or penalties under, the nondiscrimination rules of Section 105(h)(2) of the Code or any statute or regulation of similar effect (including, without limitation, the 2010 Patient Protection and Affordable Care Act, as amended by the 2010
Health Care and Education Reconciliation Act). In all cases, if the Participant becomes eligible for coverage under another employer’s group health plan or otherwise ceases to be eligible for COBRA during the
Non-CIC COBRA Payment Period, the Participant must immediately notify the Company of such event, and all payments and obligations under this Section 5(a)(iii) will cease. For purposes of this
Section 5(a)(iii), (i) references to COBRA shall be deemed to refer also to analogous provisions of state law and (ii) any applicable insurance premiums that are paid by the Company shall not include any amounts payable by a Participant
under an Internal Revenue Code Section 125 health care reimbursement plan, which amounts, if any, are the sole responsibility of the Participant. 

(b)    Change in Control Termination. Notwithstanding Section 5(a), subject to the terms of the Plan,
if a Participant’s employment with the Company is terminated as a result of a Change in Control Termination, then the Participant shall be entitled to receive the severance benefits set forth under this Section 5(b) (and shall not be
entitled to receive the severance benefits set forth under Section 5(a)). Following a Participant’s Change in Control Termination, the Participant shall be entitled to receive the Participant’s Accrued Benefits (if any) and, subject
to such Participant’s satisfaction of the requirements of Section 6, the Company shall provide the Participant with the following Severance Benefits: 

(i)    Cash Severance. The Company shall pay the Participant a
lump-sum cash severance amount, as follows: 
  

			
	 Participant Tier
	  	 Cash Severance Amount

	Tier 1	  	An amount equal to (i) 150% of the sum of (x) the Participant’s Base Salary plus (y) the Participant’s Target Bonus and (ii) a Pro-Rata Bonus
		
	Tier 2	  	An amount equal to (i) 100% of the sum of (x) the Participant’s Base Salary plus (y) the Participant’s Target Bonus and (ii) a Pro-Rata Bonus
		
	Tier 3	  	An amount equal to (i) 75% of the sum of (x) the Participant’s Base Salary plus (y) the Participant’s Target Bonus and (ii) a Pro-Rata Bonus

  
 3 

 Any cash severance payable under this Section 5(b)(i) shall be paid in a lump sum on the first regular
payroll period following the expiration of any period during which the Participant may revoke the Release pursuant to Section 6, so long as the Release becomes effective no later than sixty (60) days after the Participant’s
Separation. Notwithstanding the foregoing, if the period during which a Participant has discretion to execute or revoke the Release straddles two taxable years, then the Company shall make any severance payment due to the Participant under this
Section 5(b)(i) in the second of such taxable years, regardless of which taxable year the Participant actually delivers the executed Release to the Company. 

(ii)    Accelerated Vesting of Equity Awards. Effective as of the later of (i) the Participant’s
Separation or (ii) the consummation of the Change in Control, the Participant shall become fully vested in all of his or her then-outstanding and unvested time-based equity awards. For avoidance of doubt, if the Participant is subject to an
Involuntary Termination within three months prior to a Change in Control, the portion of the Participant’s then-outstanding and unvested equity awards that is eligible to vest and become exercisable pursuant to this Section 5(b)(ii) will
remain outstanding for three months or the occurrence of the Change in Control, whichever is sooner, so that any additional benefits pursuant to this Section 5(b)(ii) may be provided if a Change in Control occurs within three months after the
Participant’s Involuntary Termination, provided that in no event will any of the Participant’s stock options remain outstanding beyond the option’s maximum term to expiration. If a Change in Control does not occur within three months
after an Involuntary Termination, any unvested portion of a Participant’s equity awards that remain outstanding following the Participant’s Involuntary Termination will be immediately and automatically forfeited. 

(iii)    Health Benefit Continuation. If (x) the Participant was a participant in the Company’s
group health insurance plans on the date of such Participant’s Change in Control Termination and (y) timely elects continued coverage under COBRA, the Company shall pay the Employer’s portion of the Participant’s COBRA premiums
on behalf of the Participant and the Participant’s eligible dependents, until the earliest to occur of (A) the end of the number of months set forth in the table below for the Participant, as applicable, (B) the expiration of the
Participant’s eligibility for the continuation coverage under COBRA, and (C) the date when the Participant becomes eligible for substantially equivalent health insurance coverage in connection with new employment or self-employment (such
period from the Change in Control Termination through the earliest to occur of the dates set forth in clause (A) through (C), the “CIC COBRA Payment Period”). 

 

			
	 Participant Tier
	  	 Health Benefit Continuation
Period

	Tier 1	  	18 months
		
	Tier 2	  	12 months
		
	Tier 3	  	9 months

  
 4 

 These payments will be subject to applicable tax withholdings, including as necessary to avoid a violation
of, or penalties under, the nondiscrimination rules of Section 105(h)(2) of the Code or any statute or regulation of similar effect (including, without limitation, the 2010 Patient Protection and Affordable Care Act, as amended by the 2010
Health Care and Education Reconciliation Act). In all cases, if the Participant becomes eligible for coverage under another employer’s group health plan or otherwise ceases to be eligible for COBRA during the CIC COBRA Payment Period, the
Participant must immediately notify the Company of such event, and all payments and obligations under this Section 5(b)(iii) will cease. For purposes of this Section 5(b)(iii), (i) references to COBRA shall be deemed to refer also to
analogous provisions of state law and (ii) any applicable insurance premiums that are paid by the Company shall not include any amounts payable by a Participant under an Internal Revenue Code Section 125 health care reimbursement plan,
which amounts, if any, are the sole responsibility of the Participant. 
 (c)    Form of Severance under Existing
Agreement. Participants who are covered by an existing employment or severance agreement with the Company on the Effective Date agree that their existing rights under all such agreements are terminated and replaced with the provisions of
this Plan; provided, however, that for the duration of the original remaining term of the employment or severance agreement only, the timing and form of severance (i.e., lump sum or installments) in the employment or severance agreement shall
supersede the timing and form of payment provisions in this Section 5 and control the timing and form of payment of the cash severance. 

(d)    Employment with Successor. Notwithstanding anything to the contrary under the Plan, no Severance
Benefits shall be paid to a Participant who (i) is terminated as a result of such Participant failing to accept an offer of continuing employment with the Company in a comparable position, or (ii) is terminated in connection with a Change
in Control or the sale or conveyance of such Participant’s business unit or division as a result of such Participant failing to accept a comparable offer of employment made by the acquirer or successor to the Company in such transaction. A
Participant who accepts comparable employment with an acquirer or successor to the Company following a Change in Control remains entitled to receive Severance Benefits if such Participant’s employment is terminated as specified under
Section 5(b). 
 (e)    Code Section 280G Cutback. If the Severance
Benefits provided by this Plan or other benefits otherwise payable to a Participant (a) constitute “parachute payments” within the meaning of Code Section 280G, and (b) but for this Section 5(e), would be subject to the
excise tax imposed by Code Section 4999 (“Excise Tax”), then such Severance Benefits or other benefits shall be payable either in full or in such lesser amount which would result in no portion of such Severance Benefits or
other benefits being subject to the Excise Tax, whichever of the foregoing amounts, taking into account the applicable federal, state and local income and employment taxes and the Excise Tax, results in the receipt by the Participant, on an after-tax basis, of the greatest amount of such Severance Benefits and other benefits under this Plan or otherwise, notwithstanding that all or some portion of such Severance Benefits or other benefits may be
taxable under Code Section 4999. Any reduction in the Severance Benefits and other benefits required by this Section 5(e) shall be made in the following order: (i) reduction of cash payments; (ii) reduction of accelerated vesting
of equity awards other than stock options; (iii) 

  
 5 

 
reduction of accelerated vesting of stock options; and (iv) reduction of other benefits paid or provided to the Participant. All determinations required to be made under this
Section 5(e) (including whether any of the Severance Benefits or other benefits are parachute payments and subject to the Excise Tax, or whether such benefits shall be reduced) will be made by an independent accounting firm selected by the
Company. For purposes of making the calculations required by this Section 5(e), the accounting firm may make reasonable assumptions and approximations concerning applicable taxes and may rely on reasonably, good faith interpretations concerning
the application of Code Sections 280G and 4999. The Company will bear the costs that the accounting firm may reasonably incur in connection with the calculations contemplated by this Section 5(e). The accounting firm’s determination will
be binding on both the Participant and the Company absent manifest error. 
 6.    Terms and Conditions for Receipt
of Severance Benefits 
 As a condition to receiving Severance Benefits under the Plan, each Participant shall be required to
(i) sign and deliver to the Company, and not revoke or violate the terms of, a general release of all claims in the form provided by the Company (the “Release”), (ii) return all Company Property to the Company, and
(iii) comply with all agreements between the Company and the Participant relating to confidentiality, non-competition, non-solicitation and non-disparagement. The Company shall deliver the Release to the Participant within 30 days after the Participant’s Separation. The Release will specify how much time the Participant has to sign it and whether
there is a revocation period; provided, however, that the deadline for execution of the Release will in no event be later than 50 days after the Participant’s Separation and the Release must become effective by the 60th day after the Participant’s Separation. If the Release has not been signed by the Participant and become effective by the 60th day after the
Participant’s Separation, then the Participant will cease to be eligible for benefits under this Plan. 

7.    Benefit Claims 

(a)    Initial Claim. Any claims concerning eligibility, participation, benefits or other aspects of the Plan
must be submitted in writing and directed to the Committee, within thirty (30) days after the communication of the determination that is the basis of the claim. Within thirty (30) days after receiving a claim, the Committee will
(i) either accept or deny the claim completely or partially and (ii) notify a Participant of acceptance or denial of the claim. If a claim is partially or wholly denied, the Committee will provide a written denial to a Participant no later
than ninety (90) days after receipt of the initial claim request. The written denial shall include specific reasons for the denial, specific references to the Plan provisions upon which the denial was based, a description of any additional
material or information necessary for the Committee to reconsider a claim, an explanation of why such material is necessary, and instructions on the Plan’s claim review procedure. 

(b)    Appeals. A Participant may request in writing to the Committee a review of a denied claim within
thirty (30) days after receipt of such denial. Such written request must contain an explanation as to why the Participant is seeking a review. For purposes of the review, a Participant has the right to (i) submit written comments,
documents, records and other information relating to the claim for benefits; (ii) request, free of charge, reasonable access to, and copies of, all documents, records, and other information relevant to the claim for benefits;

  
 6 

 
and (iii) a review that takes into account all comments, documents, records, and other information the Participant submitted relating to the claim, regardless of whether the information was
submitted or considered in the initial decision. A decision on such review will be rendered in writing within thirty (30) days of the Committee’s receipt of a request for review. A written notice affirming the denial of a claim will set
forth the specific reasons for the decision and make specific reference to Plan provisions upon which the decision or appeal is based. In preparation for filing such a request for review, a Participant or his or her authorized representative may
review pertinent Plan documents, and as part of the written request for review, may submit issues and comments concerning the claim. No claim may be brought before or submitted to a court of law or other governmental entity unless and until the
claims process under this Section 7 has been exhausted. 
 8.    Recoupment 

(a)    Right of Recoupment. If, at any time, the Board or the Committee, as the case may be, determines that
any action or omission by a Participant constituted a violation of the conditions set forth in Section 6 to the material detriment of the Company, then such Participant’s participation in the Plan shall be immediately terminated and such
Participant shall repay to the Company, upon notice to such Participant by the Company, up to 100% of the pre-tax amount paid to such Participant pursuant to this Plan. The Board or the Committee, as the case
may be, shall determine the date of occurrence of such violation and the percentage of the pre-tax amount received pursuant to this Plan that must be repaid to the Company. 

(b)    Method of Recoupment. To the extent permitted by applicable law, the Company may enforce the
recoupment of any or all amounts due under this Section 8 by withholding future payment of any Severance Benefits, seeking reimbursement of previously paid Severance Benefits, demanding direct cash payment, reducing any amount of compensation
owed by the Company to a Participant, and/or such other means determined by the Board or Committee. 

(c)    Nonexclusive Remedy. The Company’s right of recoupment under this Section 8 is in addition
to any remedy available to the Company with respect to any Participant, including, but not limited to, the initiation of civil or criminal proceedings and any right to repayment under the Sarbanes-Oxley Act of 2002, Dodd-Frank Wall Street Reform and
Consumer Protection Act, and any other applicable law. 
 9.    General 

(a)    Amendment and Termination of the Plan. The Board or the Committee may amend or terminate the Plan in
any respect (including any change to the Severance Benefits) at any time; provided that no such amendment or termination that has the effect of reducing or diminishing the right of any Participant will be effective without the written consent of
such Participant. 
 (b)    At-Will Employment. Each Participant
is employed by the Company on an “at will” basis and nothing in this Plan shall give any Participant any right to continue in the employ of the Company. The Plan shall not be deemed (a) to give any employee or other person

  
 7 

 
any right to be retained in the employ of the Company, or (b) to interfere with the right of the Company to discharge any employee or other person at any time, with or without cause, and
with or without advance notice, which right is hereby reserved. 

(c)    Non-Duplication of Benefits. Payments to a Participant under
the Plan shall be in lieu of any severance or similar payments that otherwise might be payable under any Company plan, program, policy or agreement that provides severance benefits upon termination of employment. No Participant is eligible to
receive benefits under this Plan or pursuant to other contractual obligations more than one time. 

(d)    Unfunded Plan. The Plan shall be unfunded and all benefits payable under the Plan will be paid only
from the general assets of the Company. The Plan does not create any right to, or interest in, any specific assets of the Company and the Participants are general, unsecured creditors of the Company. 

(e)    No Mitigation. A Participant shall not be obligated to seek other employment in mitigation of the
amounts payable under any provision of the Plan, and the obtaining of such other employment shall not effect any reduction of the Company’s obligations to pay the Severance Benefits provided under the Plan (other than payments or benefits
provided under Sections 5(a)(iii) and 5(b)(iii)). 
 (f)    Withholding. The Company may withhold from any
payments made under the Plan all federal, state, local or other taxes required pursuant to any law or governmental regulation or ruling. 

(g)    Right to Offset. To the extent permitted by law, the Company may offset against any obligation to pay
any portion of any severance benefit under the Plan any outstanding amount of whatever nature that a Participant then owes to the Company in his or her capacity as an employee. However, no amount of “deferred compensation” (as defined
under Treasury Regulation section 1.409A-1(b)(1), after giving effect to the exemptions in Treasury Regulation sections 1.409A-1(b)(3) through (b)(12)) that is
payable to a Participant under the Plan may be used to offset any amount that the Participant then owes to the Company. 

(h)    Successors. The rights and obligations of a Participant under this Plan may not be transferred or
assigned without the prior written consent of the Company. This Plan shall be binding upon any surviving entity resulting from a change in control of the Company and upon any other person who is a successor by merger, acquisition, consolidation or
otherwise to the business formerly carried on by the Company without regard to whether or not such person or entity actively assumes the obligations hereunder. 

(i)    Governing Law. The Plan and all determinations made and actions taken pursuant to the Plan shall be
governed by the substantive laws, but not the choice of law rules, of the State of Delaware or by United States federal law. 

(j)    Severability. If any provision of the Plan is declared illegal, invalid or otherwise unenforceable by
a court of competent jurisdiction, the provision shall be reformed, if possible, to the extent necessary to render it legal, valid and enforceable, or otherwise deleted, and the remainder of the terms of the Plan shall not be affected except to the
extent necessary to reform or delete such illegal, invalid or unenforceable provision. 

  
 8 

 (k)    Notices. Notices and all other communications
provided for under the Plan shall be in writing and shall be deemed to have been duly given when personally delivered or when mailed by United States certified mail, return receipt requested, or by overnight courier, postage prepaid, to the
Company’s corporate headquarters address, to the attention of the Committee, or to a Participant at the home address most recently communicated by the Participant to the Company in writing. 

10.    409A Compliance. 

(a)    The Plan is intended to comply with, or otherwise be exempt from, Section 409A of the Code
(“Section 409A”). The preceding provision, however, shall not be construed as a guarantee by the Company of any particular tax effect to a Participant under the Plan. The Company shall not be liable to a
Participant for any payment made under the Plan, at the direction or with the consent of a Participant, which is determined to result in an additional tax, penalty or interest under Section 409A, nor for reporting in good faith any payment made
under the Plan as an amount includible in gross income under Section 409A. 
 (b)    “Termination of
employment,” or words of similar import, as used in this Plan means, for purposes of any payments under this Plan that are payments of deferred compensation subject to Section 409A, a Participant’s “separation from service”
as defined in Section 409A. For purposes of Section 409A, the right to a series of installment payments under this Plan shall be treated as a right to a series of separate payments. 

(c)    With respect to any reimbursement of expenses of, or any provision of
in-kind benefits to, a Participant, as specified under this Plan: (1) the expenses eligible for reimbursement or the amount of in-kind benefits provided in one
taxable year shall not affect the expenses eligible for reimbursement or the amount of in-kind benefits provided in any other taxable year, except for any medical reimbursement arrangement providing for the
reimbursement of expenses referred to in Code Section 105(b); (2) the reimbursement of an eligible expense shall be made no later than the end of the year after the year in which such expense was incurred; and (3) the right to
reimbursement or in-kind benefits shall not be subject to liquidation or exchange for another benefit. 

(d)    If a payment obligation under the Plan arises on account of a Participant’s termination of employment while a
“specified employee” (as defined under Section 409A and the regulations thereunder and determined in good faith by the Committee), any payment of “deferred compensation” (as defined under Treasury Regulation section 1.409A-1(b)(1), after giving effect to the exemptions in Treasury Regulation sections 1.409A-1(b)(3) through (b)(12)) shall be made within fifteen (15) days after the end
of the six-month period beginning on the date of such termination of employment or, if earlier, within fifteen (15) days after appointment of the personal representative or executor of a
Participant’s estate following the death of a Participant. 

  
 9 

 11.    Definitions 

The following definitions apply to the Plan: 

“Accrued Benefits” means, with respect to a Participant, the Participant’s (i) earned but unpaid Base Salary through
the date of termination of employment, (ii) accrued but unused paid time off, and (iii) unreimbursed business expenses. The Company will pay Accrued Benefits to a Participant in a cash lump sum within ten (10) days after the
Participant’s termination of employment with the Company. 
 “Affiliate” means any other entity, whether now or
hereafter existing, which controls, is controlled by, or is under common control with, the Company (including, but not limited to, joint ventures, limited liability companies, and partnerships). 

“Base Salary” means, with respect to a Participant, the Participant’s annual rate of base salary in effect as of the
date of the Participant’s Separation. 
 “Board” means the Board of Directors of Singular Genomics Systems, Inc. 

“Cause” means a Participant’s: (i) participation in or commission of any act that would constitute a felony or a
crime involving fraud, dishonesty, or moral turpitude under the laws of the United States or any state thereof; (ii) violation of any federal or state law or regulation applicable to the Company’s business that could result in material
harm to the Company or its operations; (iii) material violation of any agreement between the Participant and the Company, any Company policy, or any statutory duty owed to the Company, its employees or its stockholders; (iv) gross
misconduct or clear and material insubordination; (v) commission of or attempted commission of, or participation in, a fraud or act of dishonesty against the Company; or (vi) any unauthorized act by the Participant that results in material
harm to the Company’s business. If conduct constituting “Cause” under clause (iv), (v), or (vi) above is susceptible of cure by the Participant as determined by the Committee in good faith, Cause shall not exist unless the
Participant is first given 30 days’ written notice to cure. 
 “Change in Control” means: 

(i)    Any “person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the
“beneficial owner” (as defined in Rule 13d-3 of the Exchange Act), directly or indirectly, of securities of the Company representing more than fifty percent (50%) of the total voting power
represented by the Company’s then-outstanding voting securities; 
 (ii)    The consummation of the sale or
disposition by the Company of all or substantially all of the Company’s assets; 
 (iii)    The consummation of a
merger or consolidation of the Company with or into any other entity, other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining
outstanding or by being converted into voting securities of the surviving entity or its parent) more than fifty percent (50%) of the total voting power represented by the voting securities of the Company or such surviving entity or its parent
outstanding immediately after such merger or consolidation; or 

  
 10 

 (iv)    Individuals who are members of the Board (the “Incumbent
Board”) cease for any reason to constitute at least a majority of the members of the Board over a period of 12 months; provided, however, that if the appointment or election (or nomination for election) of any new Board member was approved
or recommended by a majority vote of the members of the Incumbent Board then still in office, such new member shall, for purposes of this Plan, be considered as a member of the Incumbent Board. 

A transaction shall not constitute a Change in Control if its sole purpose is to change the state of the Company’s incorporation or to create a holding
company that will be owned in substantially the same proportions by the persons who held the Company’s securities immediately before such transaction.  

“Change in Control Termination” means a Participant’s Involuntary Termination which occurs within three (3) months
prior to or within the twelve (12) months following a Change in Control. 
 “Code” means the Internal Revenue Code of
1986, as amended, and the regulations and Treasury guidance promulgated under it. 
 “Committee” means the Compensation
Committee of the Board. The Committee may delegate some or all of its authority under the Plan to any person, persons or subcommittee, in which event, the term “Committee” includes such person, persons or subcommittee to the extent of such
delegation. 
 “Company” means Singular Genomics Systems, Inc. and any Affiliate. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Existing Equity Award” means any outstanding equity award granted to a Participant prior to the Effective Date. 

“Involuntary Termination” means either (i) a Participant’s Termination Without Cause or (ii) a
Participant’s Resignation for Good Reason. 
 “Participant” means a person employed by the Company who has been
designated by the Committee to participate in the Plan. 
 “Plan” means this Singular Genomics Systems, Inc. Executive
Severance Plan. 
 “Pro-Rata Bonus” means a
pro-rated amount of the Participant’s Target Bonus for the Company’s fiscal year in which the Involuntary Termination occurs, based on a fraction, the numerator of which is the number of days in the
fiscal year the Participant was employed by the Company and the denominator of which is 365. 

  
 11 

 “Resignation for Good Reason” means a Participant’s Separation
as a result the Participant’s resignation from employment after one of the following conditions has come into existence without the Participant’s consent: (i) a material breach by the Company of any agreement between the Participant
and the Company; (ii) a material reduction in the Participant’s duties, position or responsibilities, taken as a whole; (iii) a material reduction of the Participant’s Base Salary and/or Target Bonus other than as part of a
similar reduction for substantially all employees or substantially all senior officers; or (iv) relocation of the Participant’s business office to another location more than fifty (50) miles away and outside the greater San Diego
area, provided such relocation also materially increases the Participant’s commuting distance, and provided that no relocation will constitute a Resignation for Good Reason if the Participant is allowed to provide services remotely (e.g.,
through telecommuting) at the time of the relocation. In order to constitute a Resignation for Good Reason, the Participant must provide the Company with written notice of the applicable condition coming into existence within 60 days after its
occurrence, the Company must fail to remedy the condition within 30 days after receiving the Participant’s written notice, and the Participant must termination his or her employment within 30 days after expiration of such cure period. For the
avoidance of doubt, an acquisition of the Company without a corresponding change in the Participant’s authority, duties or responsibilities shall not constitute grounds for a “Resignation for Good Reason.” 

“Separation” means a “separation from service,” as defined in the regulations under Section 409A. 

“Severance Benefits” means the benefits specified in Section 5 of this Plan. 

“Target Bonus” means the Participant’s short-term incentive bonus target in effect on the Participant’s date of
termination of employment. 
 “Termination Without Cause” means a Separation as a result of the termination of the
Participant’s employment by the Company without Cause and not as a result of the Participant’s death or disability. 

“Tier 1 Participant” means any Participant who the Committee has designated as a Tier 1 Participant. 

“Tier 2 Participant” means any Participant who the Committee has designated as a Tier 2 Participant. 

“Tier 3 Participant” means any Participant who the Committee has designated as a Tier 3 Participant. 

  
 12

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