Document:

EX-10.13

 Exhibit 10.13 

TOBIRA THERAPEUTICS, INC. 

701 Gateway Blvd, Suite 200 
 South
San Francisco, CA 94080 
 February 13, 2014 

Andrew A. Hindman 
 Dear Andrew: 

This letter (the “Agreement”) confirms the agreement between you and Tobira Therapeutics, Inc. (the
“Company”) regarding your resignation from employment with the Company. 
 1. Termination Date. Your
employment with the Company terminated on January 31, 2014 (the “Termination Date”). By signing this Agreement you agree that you are resigning as an employee and as a member of the Board of Directors of the Company as of the
Termination Date. All employment records will indicate that this is a voluntary resignation. 
 2. Effective Date and Revocation.
You have up to 21 days after you receive this Agreement to review it. You are advised to consult an attorney of your own choosing (at your own expense) before signing this Agreement. Furthermore, you have up to seven days after you sign this
Agreement to revoke it. If you wish to revoke this Agreement after signing it, you may do so by delivering a letter of revocation to me. If you do not revoke this Agreement, the eighth day after the date you sign it will be the “Effective
Date.” Because of the seven-day revocation period, no part of this Agreement will become effective or enforceable until the Effective Date. 

3. Salary and Vacation Pay. On the Termination Date, the Company paid you $45,461.54, less all applicable withholdings. This
amount represents all of your salary earned through the Termination Date and all of your accrued but unused vacation time or PTO (if applicable). You acknowledge that, prior to the execution of this Agreement, you were not entitled to receive any
additional money from the Company and that the only payments and benefits that you are entitled to receive from the Company in the future are those specified in this Agreement. 

4. Severance Pay. Pursuant to the terms of the Offer Letter between you and the Company dated March 5, 2011 (the
“Offer Letter”) and conditioned upon your release of claims against the Company set forth in Section 6 below, the Company will continue paying you your current base salary, less all applicable withholdings, for six
(6) months on a semi-monthly basis, starting after the Effective Date (the “Salary Continuation Payments”). The aggregate amount of the Salary Continuation Payments is equal to $180,000 (less all applicable withholding taxes).
Assuming you sign and do not revoke this Agreement, the Salary 

 Andrew A. Hindman 

February 13, 2014 
  Page
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Continuation Payments will commence on or about February 28, 2014 and, once they commence, will include any unpaid amounts accrued from the Termination Date. If you breach any provision of
this Agreement, you understand that no additional severance payments will be made; however, in such event, this Agreement shall remain in full force and effect. 

5. COBRA Premiums. You will receive information about your right to continue your group health, dental and vision insurance
coverage under the Consolidated Omnibus Budget Reconciliation Act (“COBRA”) after the Termination Date. In order to continue your coverage, you must file the required election form. Pursuant to the terms of the Offer Letter, if you
sign and do no revoke this Agreement and elect to continue group health, dental and vision insurance coverage, the Company, upon proof of payment by you for COBRA coverage, will reimburse the employer portions of the monthly premium under COBRA for
you and, if applicable, for your dependents until the earliest of (a) the end of the period of six (6) months following the month in which the Termination Date occurs, (b) the expiration of your continuation coverage under COBRA or
(c) the date when you become eligible for substantially equivalent health insurance in connection with new employment or self-employment. If necessary to avoid adverse tax consequences to you or the Company, the Company reserves the right to
treat the payment described in this Section 5 as taxable compensation income. 
 6. Stock Options. 

a. On April 7, 2011, the Company granted you an option to purchase 6,061,990 shares of its Common Stock (the “First
Option”). As of the Termination Date, you will be vested in 4,167,618 of the shares that are subject to the First Option (33 months of vesting). Subject to your acceptance of the terms of this Agreement, the First Option will be
exercisable with respect to the vested shares at any time until the date nine (9) months after the Termination Date or through October 31, 2014 (the “Vested Options Expiration Date”). The First Option will expire with
respect to the vested shares on the Vested Options Expiration Date, and it will expire with respect to the unvested shares on the Termination Date. The Notice of Stock Option Grant and Stock Option Agreement dated April 7, 2011 (attached hereto
as Exhibit B) between you and the Company (the “Stock Option Agreement”) will remain in full force and effect, and you agree to remain bound by that Agreement. This Agreement will supersede and replace the Stock Option
Agreement with respect to the Vested Options Expiration Date only. 
 b. On February 7, 2013, the Company granted you an option to
purchase 1,558,849 shares of its Common Stock (the “Second Option”). As of the Termination Date, you will be vested in zero (0) of the shares that are subject to the Second Option. The Second Option will expire with respect to
the unvested shares on the Termination Date. The Notice of Stock Option Grant and Stock Option Agreement dated February 7, 2013 between you and the Company will remain in full force and effect, and you agree to remain bound by that Agreement.
You acknowledge and agree that you have no rights to the Company’s capital stock other than those enumerated in this Section 6. 

  

 Andrew A. Hindman 

February 13, 2014 
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 7. Release of All Claims. In consideration for receiving the severance benefits
described above, and as required by the Offer Letter, to the fullest extent permitted by law, you waive, release and promise never to assert any claims or causes of action, whether or not now known, against the Company or Trinet HR Corporation or
their respective predecessors, successors or past or present subsidiaries, stockholders, directors, officers, employees, consultants, attorneys, agents, assigns and employee benefit plans with respect to any matter, including (without limitation)
any matter related to your employment with the Company or Trinet HR Corporation or the termination of that employment, including (without limitation) claims to attorneys’ fees or costs, claims of wrongful discharge, constructive discharge,
emotional distress, defamation, invasion of privacy, fraud, breach of contract or breach of the covenant of good faith and fair dealing and any claims of discrimination or harassment based on sex, age, race, national origin, disability or any other
basis under Title VII of the Civil Rights Act of 1964, the California Fair Employment and Housing Act, the Age Discrimination in Employment Act of 1967, the Americans with Disabilities Act and all other laws and regulations relating to employment.
However, this release covers only those claims that arose prior to the execution of this Agreement. Execution of this Agreement does not bar any claim that arises hereafter, including (without limitation) a claim for breach of this Agreement. This
release does not include a release of the payments and obligations created by this Agreement, a release of any vested employment benefits, a release of any claims that cannot be released by private agreement or a release of your right to
indemnification pursuant to Labor Code section 2802 and any other applicable state or federal law, and/or the Company’s Certificate of Incorporation, Bylaws, customary Indemnification Agreement and insurance policies, as set forth in paragraph
9 of the Offer Letter, or that of any successor or assign. 
 In consideration for the release of claims set forth above, to the fullest
extent permitted by law, the Company waives, releases and promises never to assert any claims or causes of action, whether or not now known, against you with respect to any matter, including (without limitation) any matter related to your employment
with the Company or the termination of that employment, including (without limitation) claims to attorneys’ fees or costs, claims of fraud, breach of contract or breach of the covenant of good faith and fair dealing; provided,
however, that this release covers only those claims that arose prior to the execution of this Agreement and it does not include, for example, any claims or causes of action related to any breach by you of this Agreement. 

8. Waiver. You and the Company expressly waive and release any and all rights and benefits under Section 1542 of the
California Civil Code (or any analogous law of any other state), which reads as follows: 
 A general release does not extend to claims which
the creditor does not know or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor. 

9. No Admission. Nothing contained in this Agreement will constitute or be treated as an admission by you or the Company of
liability, any wrongdoing or any violation of law. 

  

 Andrew A. Hindman 

February 13, 2014 
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 10. Other Agreements. At all times in the future, you will remain bound by the
Patent, Copyright and Non-Disclosure Agreement with the Company that you signed when you accepted your initial offer with the Company, a copy of which is attached as Exhibit A. 

11. Indemnification. The Company shall, to the maximum extent permitted by law, in accordance with California Labor Code section
2802, any other applicable state or federal law, and/or the Company’s Bylaws, Certificate of Incorporation, customary Indemnification Agreement, governing documents, and/or insurance policies and/or those of any successor or assign of the
Company, indemnify, defend and hold you harmless for any acts or omissions or decisions made in good faith related to the performance of services for the Company. 

12. Entire Agreement. This Agreement, together with Exhibits A and B, constitutes the entire agreement between you
and the Company regarding the subject matter of this Agreement and supersedes all prior agreements, understandings and representations regarding its subject matter, written or oral. This Agreement may be modified only in a written document signed by
you and a duly authorized officer of the Company. 
 13. Company Property. You represent that you have returned to the Company
all property that belongs to the Company, including (without limitation) copies of documents that belong to the Company and files stored on your computer(s) that contain information belonging to the Company. 

14. Confidentiality of Agreement. You agree that you will not disclose to others the existence or terms of this Agreement,
except that you may disclose such information to your spouse, attorneys or tax or financial advisers if such individuals agree that they will not disclose to others the existence or terms of this Agreement and except as may be required by law. The
Company agrees that it will not disclose the terms of this Agreement, except that (i) the Company may disclose this Agreement in confidence to its attorneys, accountants, auditors, tax preparers, and financial advisors; (ii) the Company
may disclose the terms of this letter agreement (or a summary thereof) as necessary or advisable to fulfill standard or legally required fiduciary duties or corporate reporting or disclosure requirements or to investors or potential investors; and
(iii) the Company may disclose this Agreement insofar as such disclosure may be necessary to enforce its terms or as otherwise required by law. 

15. Severability. If any term of this Agreement is held to be invalid, void or unenforceable, the remainder of this Agreement
will remain in full force and effect and will in no way be affected, and the parties will use their best efforts to find an alternate way to achieve the same result. 

16. Choice of Law. This Agreement will be construed and interpreted in accordance with the laws of the State of California
(other than their choice-of-law provisions). 

  

 Andrew A. Hindman 

February 13, 2014 
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 17. Successors and Assigns. The rights and obligations under this Agreement
shall inure to the benefit of, be enforceable by and shall be binding upon you and the Company and your respective heirs, administrators, legal representatives, personal representatives, executors, beneficiaries, owners, officers, directors,
affiliates and related companies, successors and assigns (including, without limitation, any successor in interest of the Company and /or reconstituted form of the Company resulting from the Company’s participation in any merger, acquisition,
affiliation, joint venture, sale of assets, reorganization or other business transaction). 
 18. Execution. This Agreement may be
executed in counterparts, each of which will be considered an original, but all of which together will constitute one agreement. Execution of a facsimile or pdf copy will have the same force and effect as execution of an original, and a facsimile or
pdf signature will be deemed an original and valid signature. 
 19. Authorization. The Company represents that the individual
signing this Agreement is authorized to do so and has the authority to bind the Company on behalf of which he signs to all the terms and conditions of this Agreement. 

[Remainder of Page Intentionally Left Blank] 

  

 Andrew A. Hindman 

February 13, 2014 
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 Please indicate your agreement with the above terms by signing below. 

 

			
	Very truly yours,
	
	TOBIRA THERAPEUTICS, INC.
		
	By:	 	/s/ Laurent Fischer
		 	Laurent Fischer
		 	Chairman of the Board

 I agree to the terms of this Agreement, and I am voluntarily signing this release of all claims. I
acknowledge that I have read and understand this Agreement, and I understand that I cannot pursue any of the claims and rights that I have waived in this Agreement at any time in the future. 

 

			
		 	/s/ Andrew A. Hindman
		 	Signature of Andrew A. Hindman
		
	Dated:	 	2/13/14

  

 EXHIBIT A 

PATENT, COPYRIGHT AND NON-DISCLOSURE AGREEMENT 

 EXHIBIT B 

NOTICE OF STOCK OPTION GRANT AND STOCK OPTION AGREEMENTEX-10.14

 Exhibit 10.14 

CONSULTING AGREEMENT 

THIS CONSULTING AGREEMENT (this “Agreement”) is made as of February 15, 2014 (the “Effective Date”), by and between
Tobira Therapeutics, Inc., a Delaware corporation (“Tobira”), and Caroline Loewy (“Consultant”). 

WHEREAS, Tobira is interested in receiving from Consultant, and Consultant is interested in rendering to Tobira, consulting and advisory
services, all upon the terms and conditions, and solely for the purpose, set forth herein. 
 NOW, THEREFORE, in consideration of the mutual
promises contained herein, Tobira and Consultant agree as follows: 
 1. Services. Consultant agrees to perform consulting services
for Tobira and to carry out the projects and functions specified on the Description of Work attached hereto as Exhibit A, on the terms and conditions set forth herein and on such Description of Work (the “Services”). The parties may
amend Exhibit A from time to time to add additional projects to the Description of Work, or to amend the terms of existing projects, provided that any such amendment to Exhibit A must be executed by both parties. 

2. Payment for Services. In consideration for Consultant’ Services, Tobira shall pay Consultant the compensation set forth on
Exhibit A, subject to the limitations, terms and conditions therein. The parties agree that the amounts referred to in this Section 2 constitute full and complete consideration for Consultant’s performance of the Services hereunder,
for all rights acquired by Tobira, and all of Consultant’s representations, warranties, and agreements hereunder. 
 3. Term and
Termination. 
 (a) This Agreement shall commence on the Effective Date and shall remain in effect for a term of one (1) year. The
parties also may agree in writing to extend this Agreement for an additional period of time. Notwithstanding the foregoing sentences, either party may terminate this Agreement at any time, upon thirty (30) days written notice to the other
party. This Agreement also may be earlier terminated as otherwise provided in this Section 3. 
 (b) This Agreement may be terminated
immediately by either party if the other party is in breach of this Agreement and fails to correct such breach within fifteen (15) days of written notice of such breach. A breach giving rise to termination of this Agreement may include failure
by Tobira to pay any amount due to Consultant hereunder, and may include Consultant not performing the Services in compliance with the Description of Work or failure to perform such Services in conformity with Tobira’s reasonable standards.

 (c) In addition, (i) Tobira may immediately terminate this Agreement in the event of any breach by Consultant of the obligations of
Section 5, 6, 7 or 8 hereof, and (ii) each party may immediately terminate the Agreement if the other party dissolves, liquidates, ceases to conduct business, or becomes insolvent or seeks protection pursuant to any bankruptcy,
receivership, trust deed, creditors arrangement or comparable proceeding, or such proceeding is instituted against such other party and not dismissed within sixty (60) days. 

  
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 (d) Upon termination of this Agreement for any reason, each party shall be released from all
obligations and liabilities to the other occurring or arising after the date of such termination, except as provided in Sections 4, 5, 6, 7, 8 and 9 hereof and except that any termination of this Agreement shall not relieve Consultant or Tobira from
any liability arising from any breach of this Agreement. 
 4. Relationship of Parties. 

(a) It is agreed that Consultant’s services are made available to Tobira on the basis that Consultant shall retain his individual
professional status and is an independent contractor to Tobira and not a Company employee. Consultant shall use his own discretion in performing the tasks assigned, subject to the general direction of Tobira and subject to the express condition that
Consultant shall at all times comply with applicable law. Consultant shall supply all of the tools and materials required for performance of the Services, and shall work out of Consultant’s offices to the extent practicable. 

(b) Consultant shall not be considered under the provisions of this Agreement or otherwise as having the status as an employee of Tobira, nor
shall Consultant be entitled hereafter to participate in any plans, arrangements, or distributions by Tobira relating to any pension, deferred compensation, bonds, stock bonus, stock option, hospitalization, insurance, or other benefits extended to
its employees since Consultant is performing services as an independent contractor. 
 (c) Tobira will not make deductions from its fees to
Consultant for taxes, insurance, bonds or any other subscription of any kind. Consultant acknowledges and agrees that Consultant is obligated to report as income and pay all applicable taxes in a timely manner on all compensation received by
Consultant pursuant to this Agreement, and Consultant agrees to indemnify, hold harmless and defend Tobira to the extent of any obligation imposed on Tobira to pay any withholding taxes, social security, workers’ compensation, unemployment or
disability insurance or similar items, including interest and penalties thereon, in connection with any payments made to Consultant by Tobira pursuant to this Agreement or imposed upon Tobira in the event Consultant is determined not to be an
independent contractor. If required by law or upon request of Tobira, Consultant shall maintain workers compensation, health insurance and disability insurance, as well as adequate insurance to protect itself from and indemnify Tobira against claims
giving rise to any indemnification under this Section 4. 
 5. Confidentiality. 

(a) Confidential Information. “Confidential Information” shall mean all written, visual, oral and electronic data and
information, both technical and non-technical, relating to Tobira’s business, products, processes, techniques, research, development, inventions, testing procedures and marketing that are disclosed by Tobira or any affiliate of Tobira, either

  
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directly or indirectly. Confidential Information shall include, without limitation, know-how, pre-clinical data and results, clinical research results, toxicity and hazard data, assay standards,
methods and related information, manufacturing processes and techniques, formulae, flow sheets, technical plans, chemical synthesis routes, process schematics, operational details, historical production data, anecdotal process experience, patent
applications, technical specifications, research and development plans, preclinical lead profile contents, business plans, product and market descriptions, sales, cost and promotional expenditure data, plans and projections, as well as any other
technical and business information of whatever nature. 
 (b) Exceptions. Confidential Information does not include information which
(i) is in the public domain at the time of disclosure by Tobira, (ii) becomes part of the public domain by publication or otherwise after disclosure by Tobira, other than by breach of this Agreement by Consultant, (iii) was lawfully
in Consultant’s possession, without restriction as to confidentiality or use, at the time of disclosure by Tobira, or (iv) is provided to Consultant, without restriction as to confidentiality or use, by a third party lawfully entitled to
possession of such Confidential Information and who does not violate any contractual, legal or fiduciary obligation to Tobira by providing such Confidential Information to Consultant. Without Tobira’s prior written approval, Consultant shall
not directly or indirectly disclose to anyone the terms and conditions of this Agreement. 
 In addition, Section 5(c) shall not apply
to any Confidential Information that Consultant is required to disclose under applicable laws or regulations or an order by a court or other regulatory body having competent jurisdiction; provided, however, that except where impracticable,
Consultant shall give Tobira reasonable advance notice of such disclosure requirement (which shall include a copy of any applicable subpoena or order) and shall afford Tobira an opportunity to oppose, limit or secure confidential treatment for such
required disclosure. In the event of any such required disclosure, Consultant shall disclose only that portion of the Confidential Information that Consultant is legally required to disclose. Further, specific Confidential Information disclosed to
Consultant by Tobira shall not be deemed to be publicly known, or in Consultant’s prior possession, merely because such Confidential Information is embraced by more general information which is publicly known or in the Consultant’s prior
possession. Likewise, specific Confidential Information disclosed to Consultant by Tobira or any affiliate of Tobira shall not be deemed to be publicly known merely because other Confidential Information contained in the same document or embodiment
becomes publicly known. 
 (c) Use of Confidential Information. Consultant shall use the Confidential Information solely for the
purpose of the performance on behalf of Tobira of the Services. Tobira shall not have any liability for any evaluations or investigations carried out by Consultant relating to the Confidential Information. Consultant’s right to use the
Confidential Information shall terminate upon the termination of this Agreement. Any further use of the Confidential Information by Consultant, if any, shall be governed by a separate written agreement between the parties. Consultant shall protect
the Confidential Information against disclosure to or use by third parties, shall use the same standard of care that Consultant applies to protect its own most highly confidential information (but which in any event shall be not less than a
reasonable standard of care), and shall not use the Confidential Information except for the purpose specified 

  
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above. Consultant shall not disclose the Confidential Information to any person other than its employees who have a direct need to know same for the performance of their employment duties in
connection with the purpose specified above. Consultant shall not disclose any Confidential Information to any non-employee agent or consultant without the express written permission of Tobira. Furthermore, Consultant shall obligate all such
employees, agents and consultants, both during and after their relationships with Consultant, to use and hold in confidence the Confidential Information in a manner consistent with the obligations of Consultant under this Agreement and shall take
all necessary and reasonable actions to assure such compliance. Consultant shall assume full responsibility and liability to Tobira for any unauthorized use or disclosure of any Confidential Information by any of the Consultant’s employees,
agents or consultants. 
 (d) Return of Confidential Information. Within thirty (30) days after the termination of this
Agreement or upon the sooner written request of Tobira, Consultant shall return to Tobira all written materials and documents, software and other things made available or supplied by Tobira to Consultant that contain Confidential Information, and
all copies thereof, as well as all copies of all notes, summaries, analyses and reports made by Consultant’s employees, agents and consultants containing same; provided, however, that subject to the terms and conditions of this
Agreement, Consultant shall be entitled to retain one archival copy thereof for purposes of determining its obligations under this Agreement. 

(e) No Further Rights, Obligations. Nothing in this Agreement shall create or imply any license or grant of rights to Consultant under,
or act as a waiver of any rights that Tobira may have to prevent infringement or misappropriation of, any patents, patent applications, trademarks, copyrights, trade secrets, know-how or other intellectual property rights owned or controlled by
Tobira or any of its affiliates. Furthermore, Consultant shall not have any right, title or interest in or to any of the Confidential Information. Consultant shall not seek, because of or based upon any Confidential Information, patent or any other
form of intellectual property protection with respect to or related to the Confidential Information or use the Confidential Information to obtain, or seek to obtain, a commercial advantage over Tobira. Nothing in this Agreement is intended to create
or imply any obligation on the part of either party to negotiate, discuss or enter into any other transaction or agreement with the other party. 

(f) Other Agreements of Consultant. Consultant shall not, during the term of this Agreement, improperly use or disclose any trade
secrets of any former or current employer or other person or entity with whom Consultant has an agreement or duty to keep in confidence information acquired by Consultant in confidence, if any, and Consultant shall not bring onto the premises of
Tobira any unpublished document or proprietary information belonging to such employer, person or entity unless consented to in writing by such employer, person or entity. 

(g) Confidential Information from Third Parties. Consultant recognizes that Tobira has received and in the future shall receive from
third parties their confidential or proprietary information subject to a duty on Tobira’s part to maintain the confidentiality of such information and to use it only for certain limited purposes. Consultant agrees that Consultant owes Tobira
and such third parties, during the term of this Agreement and thereafter, a duty to hold all such confidential or proprietary information in the strictest confidence and not to disclose it to any person, firm or corporation or to use it except as
necessary in carrying out the Services for Tobira consistent with Tobira’s agreements with such third parties. 

  
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 6. Ownership. 

(a) Consultant agrees that with respect to all Services performed by Consultant to date, and all Services performed by Consultant hereunder in
the future, all inventions, works of authorship, notes, drawings, designs, inventions, improvements, developments, discoveries, trade secrets, ideas, concepts, compilations, customer information and other commercially valuable information, as well
as all derivatives and modifications thereof and thereto conceived, made or discovered by Consultant, solely or in collaboration with others in performing such Services (collectively, “Work Product”), as well as all copyrights, patents and
other intellectual property rights therein and thereto, are the sole property of Tobira. Consultant further agrees to assign (or cause to be assigned) and does hereby assign fully to Tobira all right, title and interest in such Work Product and any
copyrights, patents, or other intellectual property rights relating thereto. Notwithstanding anything to the contrary herein, Tobira shall have no obligation to use the Services or Work Product or to continue such use if commenced. 

(b) Consultant hereby waives, and agrees not to assert, and shall obtain from Consultant a waiver and agreement not to assert, any and all
so-called “moral rights,” including the right to identification of authorship or limitation on subsequent modification, that Consultant has or may have in any materials or other deliverables assigned to Tobira hereunder. 

(c) Consultant agrees to assist Tobira, or its designee, at Tobira’s expense, in every proper way to secure Tobira’s rights in the
Work Product and any copyrights, patents, mask work rights or other intellectual property rights relating thereto in any and all countries, including the disclosure to Tobira of all pertinent information and data with respect thereto, the execution
of all applications, specifications, oaths, assignments and all other instruments which Tobira shall deem necessary in order to apply for and obtain such rights and in order to assign and convey to Tobira, its successors, assigns, and nominees the
sole and exclusive rights, title and interest in and to such Work Product, and any copyrights, patents, mask work rights or other intellectual property rights relating thereto. Consultant further agrees that his obligation to execute or cause to be
executed any such instrument or papers shall continue after the termination of this Agreement. 
 7. Originality and
Non-infringement. 
 (a) Consultant represents and warrants that (i) Consultant has the right to enter into and fully perform this
Agreement and to grant the rights granted hereunder, (ii) Consultant has the experience and skill to fully perform this Agreement, (iii) the Work Product and all materials and Services provided by Consultant hereunder shall be original
with them and the use thereof by Tobira or its assignees, licensees, customers, representatives, or distributors will not infringe any copyright, trade secret, patent or other intellectual property right of any third party, and (iv) no other
rights, licenses, or permissions are required from any third party nor are any payments required to be made to any third party with respect to the Work Product, the Services, and the rights granted to Tobira herein, including without limitation any
unions or guilds. 

  
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 (b) Consultant agrees to indemnify and hold Tobira harmless against any liability, loss, cost,
damage, claims, demands or expenses (including reasonable outside attorney’s fees) of Tobira or its affiliates, assignees, licensees, customers, representatives, or distributors arising out of any breach of any of the foregoing representations
and warranties or any negligent act or omission of Consultant. 
 8. No Conflicts. Consultant represents and warrants that Consultant
is free to enter into this Agreement and that the performance of this Agreement by Consultant will not conflict with or constitute a breach under any other agreement to which Consultant is bound. Tobira and Consultant agree that Consultant is free
to dispose of such portion of Consultant’s entire time, energy, and skill that Consultant would not otherwise be obligated to devote to Tobira, in such manner as Consultant sees fit and to such persons, firms, or corporations as Consultant
deems advisable so long as the same is not inconsistent with or in conflict with any provision of this Agreement, and does not create a conflict of interest between Tobira and such other persons, firms, or corporations. 

9. Miscellaneous. 
 (a)
Assignment. Neither party to this Agreement may assign or delegate its obligations under this Agreement either in whole or in part without the prior written consent of the other party. Notwithstanding the foregoing, Tobira may assign this
agreement or any of its rights or obligations hereunder to any affiliate of Tobira and any successor in interest to Tobira’s business. 

(b) Equitable Relief. Because Consultant shall have access to and become acquainted with Confidential Information of Tobira, Consultant
acknowledges that its breach of any of its obligations under this Agreement shall cause Tobira irreparable harm, for which monetary damages will be an inadequate remedy. Therefore, in the event of any such breach, Tobira shall be entitled, in
addition to any other remedy available under this Agreement, at law or in equity, to injunctive relief, including an accounting for profits, specific performance of the terms hereof and other equitable relief for such breach or the material
anticipatory breach of this Agreement, without the posting of bond or other security. If Confidential Information enters the public domain after it is disclosed to Consultant, as provided in Section 5(b), such entry shall not affect
Tobira’ right to obtain damages or other remedies for any unauthorized use or disclosure of same prior to the date it entered the public domain. 

(c) No Public Disclosure. Unless otherwise required by law, Consultant shall not disclose the existence of, any of the terms and
conditions of, or the results of any Services performed under, this Agreement without the prior written consent of Tobira. 
 (d) Waiver.
No failure on the part of either party to exercise, and no delay in exercising, any right or remedy hereunder shall operate as a waiver thereof, nor shall any single or partial exercise of any right or remedy hereunder preclude any other or a
future exercise thereof or the exercise of any other right or remedy granted hereby or by any related document or by law. 

  
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 (e) Governing Law. This Agreement shall be governed by, construed and interpreted in
accordance with the internal laws of the State of California, without giving effect to principles of conflicts of laws. 
 (f)
Miscellaneous. This Agreement sets forth the entire agreement and understanding between the parties as to the Services and merges all prior discussions, agreements, and negotiations between them as to the Services. No change or supplement to
this Agreement shall be valid or effective unless made in writing and signed by a duly authorized officer of each party. This Agreement shall be binding upon and accrue to the benefit of the successors and permitted assigns of the parties. The
descriptive headings of this Agreement are for convenience only, and shall be of no force or effect in construing or interpreting any of the provisions of this Agreement. This Agreement shall not be strictly construed against either party. This
Agreement may be executed simultaneously in any number of counterparts, any one of which need not contain the signature of more than one party, but all such counterparts taken together shall constitute one and the same agreement. If any provision of
this Agreement shall be held to be invalid or unenforceable by a court of competent jurisdiction, no other provision of this Agreement shall be affected thereby. 

(g) Notices. Any notice required or permitted hereunder shall be given to the appropriate party at the address specified beneath such
party’s signature below or at such other address as the party may hereafter specify in writing. Such notice shall be deemed given upon personal delivery to the appropriate address, five (5) business days after the date of mailing if sent
by certified or registered U.S. mail, or two (2) business days after the date of deposit with Federal Express or similar overnight courier. 

(h) Stock Option. On September 18, 2012 the Company granted Consultant an option to purchase 1,885,066 shares of its Common Stock
(the “Option”). As of the date hereof, Consultant will be vested in 667,627 of the shares that are subject to the Option. By signing this Agreement, Consultant agrees that no additional shares subject to the Option will continue to vest
during the term of this Agreement. The Option is exercisable with respect to the vested shares at any time until the date that is the latter of 1) two (2) weeks following the termination of this Agreement (the “Option Termination
Date”) and 2) June 16, 2014. The Option will expire with respect to the vested shares on the Option Termination Date, and it will expire with respect to the unvested shares on the date hereof. The Stock Option Agreement dated
September 18, 2012, between Consultant and the Company, and as amended hereby, will remain in full force and effect, and Consultant agrees to remain bound by that Stock Option Agreement. 

(i) Survival of Terms. The provisions of Sections 4, 5, 6, 7, 8 and 9 hereof shall survive termination of this Agreement. 

[Signature Page Follows] 

  
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 IN WITNESS WHEREOF, the parties have caused their duly authorized representatives to execute this
Agreement as of the date(s) set forth below. 
  

									
	TOBIRA THERAPEUTICS, INC.	 		 	CAROLINE LOEWY
					
	By:	 	/s/ Laurent Fischer	 		 	By:	 	/s/ Caroline Loewy
	Name:	 	Laurent Fischer	 		 	Name:	 	Caroline Loewy
	Title:	 	Chairman	 		 	Title:	 	Consultant
		 		 	

  

							
	Address:	  	701 Gateway Blvd.	  	Address:	  	
		  	Suite 200	  		  	
		  	South San Francisco, CA 94080	  		  	
		  	Attn: Chief Executive Officer	  		  	

  
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 EXHIBIT A 

Description of Work and Compensation 

Work: 
 Consultant shall provide the following Services
pursuant to this Agreement, as well as such other Services as may be reasonably requested by Tobira from time to time: 
 Consult and Advise Tobira with
respect to business development and financing matters. 
 Consultant shall report to, and shall receive project directions from Laurent Fischer,
Tobira’s Chairman, or such other Company officers or consultants as Tobira may specify from time to time. 
 Compensation: 

As compensation for Consultant’s Services, Tobira shall pay Consultant the sum of $500.00 per hour, not to exceed $5,000.00 in any given calendar month
without consent from the Chairman/Acting CEO. At the end of each calendar month Consultant shall submit an invoice to Tobira, which invoice shall reflect the total number of hours worked hereunder for that month and the total amount due for such
services. Tobira will pay consultant any undisputed amounts specified in such invoice within Thirty (30) days of receipt of such invoice. 

  
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