Document:

Amended and Restated 2004 Non-Employee Director Option Program

 Exhibit 4.11 
 DYNAVAX TECHNOLOGIES CORPORATION 
 AMENDED AND RESTATED 2004 NON-EMPLOYEE DIRECTOR OPTION

 PROGRAM 
 AND

 AMENDED AND RESTATED 2005 NON-EMPLOYEE DIRECTOR CASH COMPENSATION PROGRAM 

EFFECTIVE APRIL 14, 2005 

AMENDED APRIL 17, 2012 

(REVISION VERSION 4.0) 

ARTICLE I 
 ESTABLISHMENT AND
PURPOSE OF THE PROGRAM 
  

	1.1	Establishment of Program 

 The Dynavax Technologies
Corporation 2004 Non-Employee Director Option Program, as revised herein, including the Non-Employee Director Cash Compensation Program (collectively, the “Director Program”) is adopted pursuant to the Dynavax Technologies Corporation 2011
Equity Incentive Plan (the “2011 Plan”), in addition to the terms and conditions set forth below, is subject to the provisions of the Plan. 
  

	1.2	Purpose of Program 

 The purpose of the Director Program is to
enhance the ability of the Company to attract and retain directors who are not Employees (“Non-Employee Directors”) through an Option and Cash Compensation program. 

 

	1.3	Effective Date of the Program 

 The Director Program is
effective as of the Registration Date, and as revised on April 17, 2012. 
 ARTICLE II 

DEFINITIONS 
 Capitalized terms in this
Director Program, unless otherwise defined herein, have the meaning given to them in the Plan. 
 ARTICLE III 

OPTION TERMS 
  

	3.1	Date of Grant and Number of Shares 

 Effective April 14,
2005, a Non-Qualified Stock Option to purchase 20,000 shares of Common Stock shall be granted (the “Initial Grant”) to each Non-Employee Director and 30,000 shares shall be granted to the Non-Employee Chairman of the Board (the
“Initial Grant”), and such Initial Grant to be made to Non-Employee Directors elected or appointed to the Board upon the date each such Non-Employee Director first becomes a Non-Employee Director. 

  
 1 

 

 In addition, immediately following each annual meeting of the Company’s stockholders, commencing with the annual
meeting of the Company’s stockholders in 2012, each Non-Employee Director who continues as a Non-Employee Director following such annual meeting shall be granted a Non-Qualified Stock Option to purchase 17,500 shares of Common Stock (a
“Subsequent Grant”). Based on the Non-Employee Director’s election date, the first subsequent grant shall be pro-rated as follows: 
  

			
	    Service Period from Election Date
	 	   Option Grant
Schedule

	 More than 10 up to 12 months
	 	 100% of grant (17,500
shares)

	 More than 7 months, but less than 10
	 	 75% of grant (13,125
shares)

	 More than 4 months, but less than 7
	 	 50% of grant (8,750
shares)

	 More than 1 month, but less than 4
	 	 25% of grant (4,375
shares)

 Each such Subsequent Grant shall be made on the date of the annual stockholders’ meeting in question. 

 

	3.2	Vesting 

 Each Initial Grant of Common Stock subject to the
Option under the Director Program shall vest twenty-five percent (25%) twelve (12) months after the grant date and an additional twenty-five percent (25%) of the shares of Common Stock subject to the Option shall vest on each yearly
anniversary of the grant date thereafter, such that the Option will be fully exercisable four (4) years after its date of grant. 
 Each Subsequent
Grant under the Director Program will vest and become exercisable as to all of the shares of Common Stock subject to the Option twelve (12) months after the grant date. 

 

	3.3	Exercise Price 

 The exercise price per share of Common Stock
of each Initial Grant and Subsequent Grant shall be one hundred percent (100%) of the Fair Market Value per share on the date of grant. 
  

	3.4	Corporate Transaction/Change in Control 

 Each Option under
the Director Program shall be subject to the provisions of Section 9 of the 2011 Plan relating to the exercise or termination of the Option in the event of a Corporate Transaction or a Change in Control. 

 

	3.5	Other Terms 

 The Administrator (the “Dynavax Board of
Directors”) of the Plan shall determine the remaining terms and conditions of the Options awarded under the Program. 
 ARTICLE IV

 CASH COMPENSATION TERMS 
  

	4.1	Annual Fees 

 Each Non-Employee Director currently on the
Company’s board, or elected in 2012 and thereafter, shall receive an annual retainer fee of $40,000. The Chairman of the Board shall receive an annual retainer fee of $65,000. Such annual retainer fees will be paid in quarterly installments at
the end of each fiscal quarter where such person is an active director of the board (“active director” requires attendance at 75% of the annually scheduled board meetings) and is inclusive of 5 scheduled board meetings. In the event there
are more than 5 board meetings in the calendar year, each director attending the meeting in person will receive a fee of $2,000 per meeting or $500 per meeting if attending by telephone. 

  
 2 

 

	4.2	[Intentionally Removed] 

  

	4.3	Committee Meeting Fees 

 The Chairman of the Audit Committee
shall receive an annual retainer of $20,000. Each member of the audit committee shall receive a fee of $1,500 for each Audit Committee meeting attended in person or $500 for each Audit Committee meeting attended by telephone. 

The Chairman of the Compensation Committee shall receive an annual retainer of $15,000. Each member of the compensation committee shall receive a fee of $1,000 for
each committee meeting attended in person or $500 for each committee meeting attended by telephone. 
 The Chairman of the Nominating and Governance
Committee shall receive an annual retainer of $5,000. Each member of the nominating committee shall receive a fee of $1,000 for each committee meeting attended in person or $500 for each committee meeting attended by telephone. 

Such annual retainer fees for chairman of a committee will be paid quarterly at the end of each fiscal quarter where such person is an active Chairman of the
Committee and an Active Director. Such committee fees will be paid quarterly at the end of each fiscal quarter where such person is an Active Director. 
  

	4.4	Travel and Related Costs 

 Reasonable travel and related costs
associated with attending Board and committee meetings shall be reimbursed. The Board member needs to submit proper documentation for reimbursement. 

  
 3Form of Amendment to 2010 Restricted Stock Award Agreement as of August 3, 2012

 EXHIBIT 10.47 
 AMENDMENT TO 2010 RESTRICTED STOCK AWARD AGREEMENT 
 This Amendment
(“Amendment”), dated as of August 3, 2012, amends the Restricted Stock Award Agreement dated August 13, 2010 (the “Agreement”) and issued by Rockwell Medical, Inc. (f/k/a Rockwell Medical Technologies, Inc.)
(“Company”) to                          (“Holder”) and is made in accordance with Section 13 of
the Agreement and Sections 1.5 and 10.6 of the Company’s Amended and Restated Long Term Incentive Plan (the “LTIP”). 
 WHEREAS, the Company and Holder have determined that the terms of this Amendment are in the Company’s best interests and desire to amend the Agreement in the manner set forth herein; and 

WHEREAS, the Compensation Committee of the Company’s Board of Directors has approved this Amendment to the extent required in the
LTIP; 
 NOW THEREFORE, the Agreement is amended as set forth below. 

1. The Section 2(a) of the Agreement is amended and restated in its entirety to read as follows: 

(a) So long as the Employee continues to be employed by the Company or its Subsidiaries, the Restricted Stock shall become vested and
non-forfeitable upon the earliest to occur of (i) in two equal installments on (A) March 8, 2013 and (B) the thirty-six month anniversary of the Grant Date (the “Vesting Dates”), or (ii) subject to the
Committee’s right to declare, pursuant to Section 9.2(c) of the Plan, that the Restricted Stock shall not become immediately vested upon a Change in Control in which the successor company assumes the Restricted Stock Award, the occurrence
of a Change in Control. 
 2. The term “Agreement” as used in the Agreement shall be deemed to refer to the Agreement
as amended hereby. 
 3. Except as specifically modified herein, the remaining provisions of the Agreement remain in full force
and effect. 
 IN WITNESS WHEREOF, the undersigned have caused this Amendment to be executed as of the date first set forth
above. 
  

					
	ROCKWELL MEDICAL, INC.	 		 	HOLDER
			
	By:
                                         
                                         
                   	 		 	          
                                         
                                         
              
			
	Its:
                                         
                                         
                    	 		 	Name
                                         
                                         
               

  
 4Twelfth Amendment to Amended and Restated Loan Agreement

 Exhibit 10.1 
 TWELFTH AMENDMENT TO AMENDED AND RESTATED LOAN AGREEMENT 
 This
Twelfth Amendment to Amended and Restated Loan Agreement (this “Amendment”) is made and entered into to be effective for all purposes as of July 30, 2012, by and between JPMORGAN CHASE BANK, NA, a national banking association
[successor by merger to Bank One, NA (Illinois)] with its main office in Chicago, Illinois and with a banking office located at 420 Throckmorton Street, Suite 400, Fort Worth, Texas 76102 (“Lender”), and PLAINSCAPITAL CORPORATION, a Texas
corporation (“Borrower”). 
 RECITALS: 
 A. Lender’s predecessor and Borrower have previously executed that certain Amended and Restated Loan Agreement (as amended, the “Agreement”) dated October 1, 2001, which has been
amended by: (i) that certain First Amendment to Amended and Restated Loan Agreement dated August 1, 2002; (ii) that certain Second Amendment to Amended and Restated Loan Agreement dated as of August 1, 2003; (iii) that
certain Third Amendment to Amended and Restated Loan Agreement dated as of June 1, 2004; (iv) that certain Fourth Amendment to Amended and Restated Loan Agreement dated as of November 21, 2005; (v) that certain Fifth Amendment to
Amended and Restated Loan Agreement dated as of October 16, 2006; (vi) that certain Sixth Amendment to Amended and Restated Loan Agreement dated as of December 19, 2007; (vii) that certain Seventh Amendment to Amended and
Restated Loan Agreement dated as of June 19, 2009; (viii) that certain Eighth Amendment to Amended and Restated Loan Agreement, dated April 23, 2010; (ix) that certain Ninth Amendment to Amended and Restated Loan Agreement, dated
July 29, 2010; (x) that certain Tenth Amendment to Amended and Restated Loan Agreement, dated January 10, 2011; and (xi) that certain Eleventh Amendment to Amended and Restated Loan Agreement, dated July 26, 2011.

 B. Under the Agreement, Lender agreed to extend to Borrower a revolving line of credit (the “LOC”) evidenced by
that certain Promissory Note dated as of June 1, 2004, which has been executed by Borrower and is payable to Lender in the maximum principal amount of $20,000,000.00 (the “Original Revolving Note”). 

C. The Original Revolving Note was amended and restated as well as renewed and extended pursuant to that certain Amended and Restated
Promissory Note, dated as of November 21, 2005, made by Borrower and payable to the order of Lender (the “First Amended Revolving Note”). 
 D. The First Amended Revolving Note was amended and restated as well as renewed and extended pursuant to that certain Second Amended and Restated Promissory Note, dated as of October 16, 2006, made
by Borrower and payable to the order of Lender (the “Second A&R Revolving Note”). 
 E. The Second A&R
Revolving Note was amended and restated as well as renewed and extended pursuant to that certain Third Amended and Restated Promissory Note, dated as of December 19, 2007, made by Borrower and payable to the order of Lender (the “Third
A&R Revolving Note”). 

  
 TWELFTH AMENDMENT TO
AMENDED AND RESTATED LOAN AGREEMENT – Page 1 

 F. The Third A&R Revolving Note was amended and restated as well as renewed and extended
pursuant to that certain Fourth Amended and Restated Promissory Note, dated as of June 19, 2009, made by Borrower and payable to the order of Lender (the “Fourth A&R Revolving Note”). 

G. The Fourth A&R Revolving Note was amended and restated as well as renewed and extended pursuant to that certain Fifth Amended and
Restated Promissory Note, dated as of July 29, 2010, made by Borrower and payable to the order of Lender (the “Fifth Note”). 
 H. The Fifth Note was amended and restated as well as renewed and extended pursuant to that certain Sixth Amended and Restated Promissory Note, dated as of July 26, 2011, made by Borrower and payable
to the order of Lender (the “Note”). 
 I. Borrower has now requested that Lender agree to renew the LOC and modify
certain provisions under the Loan Agreement, and Lender is willing to do so provided that, among other things, the Agreement is amended as herein provided. 
 I. The parties to this Amendment desire to modify and amend the Agreement as hereinafter set forth and to enter into this Amendment. 

AGREEMENT: 
 NOW, THEREFORE, in consideration of the premises and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and subject to all terns, conditions, and
covenants herein set forth, Lender and Borrower hereby covenant and agree as follows: 
 1. Acknowledgment of Outstanding
Balance; Reduction of LOC. The parties hereto acknowledge that the outstanding principal balance under the Note as of the date of this Agreement is FOURTEEN MILLION ONE HUNDRED SIXTY THOUSAND AND NO/100 Dollars ($14,160,000.00). Furthermore and
notwithstanding anything to the contrary, the parties hereto agree that from and after the date hereof the aggregate amount outstanding under the LOC shall at no time exceed $14,160,000.00. 

2. Conversion to Non-Revolving. The parties hereto agree that the LOC shall, from after the date hereof, be a term loan pursuant
to which Borrower shall have no further right to borrow and shall hereafter be referred to as the “Term Loan”. 
 3.
Renewal and Extension of Maturity. Notwithstanding anything to the contrary, the Term Loan is hereby renewed and extended to July 31, 2013, and the definition of “Termination Date” under the Agreement is hereby revised to be
July 31, 2013. 
 4. Amended and Restated Revolving Note. In furtherance of the extension of the Term Loan, the Note
shall be amended, restated and reduced by that certain Seventh Amended and Restated Promissory Note (the “New Note”), dated of even date herewith, made by Borrower and payable to the order of Lender in the maximum principal amount
of $14,160,000.00. 

  
 TWELFTH AMENDMENT TO
AMENDED AND RESTATED LOAN AGREEMENT – Page 2 

 5. Conditions Precedent. The obligation of Lender to enter into this Amendment is subject to the
performance of each of the following conditions precedent: 
 (a) Term Note. Borrower shall have executed
and delivered to Lender the New Note, which shall be referred to as the “New Term Note” and shall replace the “Revolving Note” as defined, and wherever used, in the Agreement; 

(b) Resolutions of Borrower. Lender shall have received corporate resolutions of the Board of Directors or
Executive Committee of Borrower, certified by the Secretary of Borrower, which resolutions authorize the execution, delivery and performance by Borrower of this Amendment and the New Note. Included in said resolutions or by separate document, Lender
shall receive a certificate of incumbency certified by the Secretary of Borrower certifying the names of each officer authorized to execute this Amendment and the New Note, together with specimen signatures of such officers; 

(c) Additional Papers. Borrower shall have delivered to Lender such other documents, records, instruments,
papers, opinions, and reports, as shall have been requested by Lender, to evidence the status or organization or authority of Borrower or to evidence the payment or the securing of the Obligations, all in form satisfactory to Lender and its counsel;
and 
 (d) Proceedings. All proceedings of Borrower in connection with the transactions contemplated
by this Amendment and all documents incident thereto shall be satisfactory in form and substance to Lender and its counsel; and Lender shall have received copies of all documents or other evidence which Lender or its counsel may reasonably request
in connection with said transactions and copies of records and all proceedings in connection therewith, all in form and substance satisfactory to Lender and its counsel. 
 6. Definitions. All capitalized terms used in this Amendment which are not otherwise defined in this Amendment shall have the same meaning as given to such terms in the Agreement. For the avoidance
of doubt and notwithstanding anything to the contrary, the term “Net Income” shall for all purposes mean, with respect to the four (4) calendar quarters immediately preceding any date of computation of Net Income, the net
income for Bank or any other Banking Subsidiary for such four (4) calendar quarters. 
 7. Representations and
Warranties. Borrower represents and warrants to Lender that (a) all of the representations and warranties contained in the Agreement, the Security Instruments, and all instruments and documents executed pursuant thereto or contemplated
thereby are true and correct in all material respects on and as of the date of this Amendment, (b) the execution, delivery and performance of this Amendment, the New Note and any and all other documents executed and/or delivered in connection
herewith have been authorized by all requisite action on the part of Borrower, (c) no Event of Default exists under the Agreement and there are no defenses, counterclaims or offsets to the Note, the New Note, or any of the Security Instruments,
and (d) no change has occurred, either in any case or in the aggregate, in the 

  
 TWELFTH AMENDMENT TO
AMENDED AND RESTATED LOAN AGREEMENT – Page 3 

 
condition, financial or otherwise, of Borrower or Bank or with respect to Borrower’s or Bank’s assets or properties from the facts represented in the Agreement or any Security
Instrument which would have a material adverse effect on the financial condition, business, or assets of Borrower or Bank. 
 8.
Survival of Representations, Warranties and Covenants. All representations, warranties and covenants made in this Amendment or in any other document furnished in connection with this Amendment shall survive the execution and delivery of this
Amendment, and no investigation by Lender or any closing shall affect such representations, warranties and covenants or the right of Lender to rely upon them. 
 9. References to Agreement. The Agreement and any and all other agreements, documents, or instruments now or hereafter executed and delivered pursuant to the terms hereof or pursuant to the terms
of the Agreement, as amended hereby, are hereby amended so that any reference therein to the Agreement shall mean a reference to the Agreement as amended hereby. 
 10. Further Assurances. Borrower agrees that at any time and from time to time, upon the request of Lender, Borrower will execute and deliver such further documents and do such further acts and
things as Lender may reasonably request in order to fully effect the purposes of this Amendment and to provide for the payment of the Obligations. 
 11. Acknowledgment. Borrower ratifies and confines that the Agreement as amended hereby, the Note, the Security Instruments and the other Loan Documents are and remain in full force and effect in
accordance with their respective terms, that the Security Instruments secure the payment of all of the Obligations, that the Collateral is unimpaired by this Amendment, and that the Collateral is security for the payment and performance in full of
all of the Obligations. The undersigned officer of Borrower executing this Amendment represents and warrants that he has full power and authority to execute and deliver this Amendment on behalf of Borrower, that such execution and delivery has been
duly authorized by the Board of Directors of Borrower, and that the resolutions of Borrower previously delivered to Lender in connection with the execution and delivery of the Agreement are and remain in full force and effect and have not been
altered, amended or repealed in any manner. 
 12. Existing Loan Documents. Except as amended and modified by this
Amendment, the Agreement, the Note, the Security Instruments and all other Loan Documents shall remain in full force and effect in accordance with the terms and provisions thereof. Any reference in any of the Loan Documents to the “Amended and
Restated Loan Agreement” shall be deemed to be references to the Agreement as amended hereby through the date hereof. In the event of any conflict between this Amendment and the Agreement, this Amendment shall control and the Agreement shall be
construed accordingly. 
 13. Counterparts. This Amendment has been executed in a number of identical counterparts, each
of which constitutes an original and all of which constitute, collectively, one agreement; but in making proof of this Amendment, it shall not be necessary to produce or account for more than one such counterpart. 

  
 TWELFTH AMENDMENT TO
AMENDED AND RESTATED LOAN AGREEMENT – Page 4 

 14. Severability. In the event any one or more of the provisions contained in the
Agreement or this Amendment should be held to be invalid, illegal or unenforceable in any respect, the validity, enforceability and legality of the remaining provisions contained herein and therein shall not in any way be affected or impaired
thereby, and shall be enforceable in accordance with their respective terms. 
 15. Expenses. Borrower agrees to pay to
Lender all reasonable costs incurred (whether by Lender, Borrower, or otherwise) in connection with the preparation, execution, and consummation of this Amendment and the consummation of all transactions contemplated by this Amendment. 

16. Applicable Law. THIS AMENDMENT, THE NEW NOTE AND ALL OTHER DOCUMENTS EXECUTED PURSUANT HERETO SHALL BE DEEMED TO HAVE BEEN
MADE AND TO BE PERFORMABLE IN FORT WORTH, TARRANT COUNTY, TEXAS, AND SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF TEXAS. THE PARTIES TO THIS AMENDMENT HEREBY CONSENT THAT VENUE OF ANY ACTION BROUGHT UNDER THIS
AMENDMENT OR UNDER ANY OF THE LOAN DOCUMENTS SHALL BE IN TARRANT COUNTY, TEXAS. 
 17. Successors and Assigns. This
Amendment is binding upon and shall inure to the benefit of Lender and Borrower and their respective successors and assigns, except Borrower may not assign or transfer any of its rights or obligations hereunder without the prior written consent of
Lender. 
 18. Headings. The headings, captions, and arrangements used in this Amendment are for convenience only and
shall not affect the interpretation of this Amendment. 
 19. No Oral Agreements. Pursuant to Section 26.02 of the
Texas Business and Commerce Code the following notice is given: 
 THIS WRITTEN AMENDMENT AND THE OTHER LOAN DOCUMENTS REPRESENT
THE FINAL AGREEMENT BETWEEN THE PARTIES AND MAY NOT BE CONTRADICTED BY EVIDENCE OF PRIOR, CONTEMPORANEOUS, OR SUBSEQUENT ORAL AGREEMENTS OF THE PARTIES. THERE ARE NO UNWRITTEN ORAL AGREEMENTS BETWEEN THE PARTIES. 

  
 TWELFTH AMENDMENT TO
AMENDED AND RESTATED LOAN AGREEMENT – Page 5 

 IN WITNESS WHEREOF, Lender and Borrower, by and through their respective duly authorized
officers or representatives, have caused this Amendment to be executed and delivered as of the date first above written. 
  

			
	LENDER:
	
	JPMORGAN CHASE BANK, NA, a national banking association [successor by merger to Bank One, NA (Illinois)]
		
	By:	 	/s/ Timothy F. Johnson
		 	Name: Timothy F. Johnson
		 	Title:   Senior Vice President

  
 TWELFTH AMENDMENT TO
AMENDED AND RESTATED LOAN AGREEMENT – Page 6 

 
			
	BORROWER:
	
	PLAINSCAPITAL CORPORATION
		
	By:	 	/s/ John A. Martin
		 	Name: John A. Martin
		 	Title:   Executive Vice President and
		 	            Chief Financial Officer

  
 TWELFTH AMENDMENT TO
AMENDED AND RESTATED LOAN AGREEMENT – Page 7

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