Document:

<PAGE>

                                                                   EXHIBIT 4.4

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THIS
WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED,
OR ANY APPLICABLE STATE SECURITIES LAWS, AND MAY NOT BE SOLD OR TRANSFERRED
UNLESS SUCH SALE OR TRANSFER IS IN ACCORDANCE WITH THE REGISTRATION REQUIREMENTS
OF SUCH ACT AND APPLICABLE LAWS OR SOME OTHER EXEMPTION FROM THE REGISTRATION
REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS IS AVAILABLE WITH RESPECT THERETO.

                          COMMON STOCK PURCHASE WARRANT

Warrant No. 3                                            Number of Shares 20,000

                           EXACT SCIENCES CORPORATION

                           Void after November 7, 2004

         1. ISSUANCE. This Warrant is issued to TBCC Funding Trust II, a
Delaware business trust by EXACT Sciences Corporation, a Delaware corporation
(hereinafter with its successors called the "Company").

         2. PURCHASE PRICE; NUMBER OF SHARES. Subject to the terms and
conditions hereinafter set forth, the registered holder of this Warrant (the
"Holder"), commencing on the date hereof, is entitled upon surrender of this
Warrant with the subscription form annexed hereto duly executed, at the office
of the Company, 63 Great Road, Maynard, Massachusetts 01754, or such other
office as the Company shall notify the Holder of in writing, to purchase from
the Company at a price per share (the "Purchase Price") of $7.33, TWENTY
THOUSAND (20,000) fully paid and nonassessable shares of Common Stock, $0.01 par
value, of the Company (the "Common Stock"). Until such time as this Warrant is
exercised in full or expires, the Purchase Price and the securities issuable
upon exercise of this Warrant are subject to adjustment as hereinafter provided.

         3. PAYMENT OF PURCHASE PRICE. The Purchase Price may be paid (i) in
cash or by check, (ii) by the surrender by the Holder to the Company of any
promissory notes or other obligations issued by the Company, with all such notes
and obligations so surrendered being credited against the Purchase Price in an
amount equal to the principal amount thereof plus accrued interest to the date
of surrender, (iii) through delivery by the Holder to the Company of other
securities issued by the Company, with such securities being credited against
the Purchase Price in an amount equal to the Fair Market Value thereof (as
defined in Section 4 hereof), or (iv) by any combination of the foregoing.

         4. NET ISSUE ELECTION. The Holder may elect to receive, without the
payment by the Holder of any additional consideration, shares equal to the value
of this Warrant by the surrender

<PAGE>

                                      -2-

of this Warrant to the Company, with the net issue election notice annexed
hereto duly executed, at the office of the Company. Thereupon, the Company shall
issue to the Holder such number of fully paid and nonassessable shares of Common
Stock as is computed using the following formula:

                                   X = Y (A-B)
                                       -------
                                        A

where

                           X = the number of shares to be issued to the Holder
                  pursuant to this Section 4.

                           Y = the number of shares covered by this Warrant.

                           A = the Fair Market Value of one share of Common
                  Stock as at the time the net issue election is made pursuant
                  to this Section 4.

                           B = the Purchase Price in effect under this Warrant
                  at the time the net issue election is made pursuant to this
                  Section 4.

                  For the purposes of this Warrant, "Fair Market Value" of a
share of Common Stock shall mean:

                  (i) If the Company's Common Stock is traded on an exchange or
              is quoted on the National Association of Securities Dealers, Inc.
              Automated Quotation National Market ("Nasdaq"), the last reported
              sale price of the Common Stock on the last business day before the
              effective date of exercise or if no such sale is made on such day,
              the mean of the closing bid and asked prices for such day on such
              exchange or on the Nasdaq National Market;

                  (ii) If the Company's Common Stock is not traded on an
              exchange or on the Nasdaq National Market but is traded in the
              over-the-counter market, the mean of the last bid and asked prices
              reported on the last business day before the effective date of
              exercise (1) by the Nasdaq or (2) if reports are unavailable under
              clause (1) by the National Quotation Bureau Incorporated;

                  (iii) If the Company's Common Stock is not publicly traded,
              then as determined in good faith by the Board of Directors of the
              Company upon review of relevant factors.

         5. ISSUANCE DATE. The person or persons in whose name or names any
certificate representing shares of Common Stock is issued hereunder shall be
deemed to have become the holder of record of the shares represented thereby as
at the close of business on the date this Warrant is exercised with respect to
such shares, whether or not the transfer books of the Company shall be closed.

<PAGE>

                                      -3-

         6. EXPIRATION DATE. This Warrant shall expire at the close of business
on November 7, 2004 and shall be void thereafter.

         7. RESERVED SHARES; VALID ISSUANCE. The Company covenants that it will
at all times from and after the date hereof reserve and keep available such
number of its authorized shares of Common Stock, free from all preemptive or
similar rights therein, as will be sufficient to permit the exercise of this
Warrant in full. The Company further covenants that such shares as may be issued
pursuant to the exercise of this Warrant will, upon issuance, be duly and
validly issued, fully paid and nonassessable and free from all taxes, liens and
charges with respect to the issuance thereof.

         8. DIVIDENDS. If after the Original Issue Date (as defined in Section
13 hereof) the Company shall subdivide the Common Stock, by split-up or
otherwise, or combine the Common Stock, or issue additional shares of Common
Stock in payment of a stock dividend on the Common Stock, the number of shares
issuable on the exercise of this Warrant shall forthwith be proportionately
increased in the case of a subdivision or stock dividend, or proportionately
decreased in the case of a combination, and the Purchase Price shall forthwith
be proportionately decreased in the case of a subdivision or stock dividend, or
proportionately increased in the case of a combination.

         9. SALE OF ASSETS AND MERGERS. Upon the sale by the Company of all or
substantially all of its assets, or the merger or consolidation of the Company
with or into another entity in a transaction where the shares of the Company's
capital stock outstanding immediately prior to the closing of such merger or
consolidation represent or are converted into or exchanged for shares that
represent less than a majority of the shares of capital stock of the resulting
or surviving entity outstanding immediately after the closing of such merger or
consolidation (each, a "Business Event"), this Warrant shall expire and
thereafter be void. The Company shall give the Holder of this Warrant seven (7)
business days (the "Merger Exercise Period") prior written notice of a Business
Event. Holder may exercise this Warrant, in full or in part, during the Merger
Exercise Period. Upon the expiration of the Merger Exercise Period, this Warrant
shall expire and thereafter be void.

         10. FRACTIONAL SHARES. In no event shall any fractional share of Common
Stock be issued upon any exercise of this Warrant. If, upon exercise of this
Warrant as an entirety, the Holder would, except as provided in this Section 10,
be entitled to receive a fractional share of Common Stock, then the Company
shall issue the next higher number of full shares of Common Stock, issuing a
full share with respect to such fractional share.

         11. CERTIFICATE OF ADJUSTMENT. Whenever the Purchase Price is adjusted,
as herein provided, the Company shall promptly deliver to the Holder a
certificate setting forth the Purchase Price after such adjustment and setting
forth a brief statement of the facts requiring such adjustment.

<PAGE>

                                      -4-

         12. NOTICES OF RECORD DATE, ETC. In the event of:

                  (a) any taking by the Company of a record of the holders of
any class of securities for the purpose of determining the holders thereof who
are entitled to receive any dividend or other distribution, or any right to
subscribe for, purchase or otherwise acquire any shares of stock of any class or
any other securities or property, or to receive any other right,

                  (b) any reclassification of the capital stock of the Company,
capital reorganization of the Company, consolidation or merger involving the
Company, or sale or conveyance of all or substantially all of its assets, or

                  (c) any voluntary or involuntary dissolution, liquidation or
winding-up of the Company,

then and in each such event the Company will mail or cause to be mailed to the
Holder a notice specifying (i) the date on which any such record is to be taken
for the purpose of such dividend, distribution or right, and stating the amount
and character of such dividend, distribution or right, or (ii) the date on which
any such reclassification, reorganization, consolidation, merger, sale or
conveyance, dissolution, liquidation or winding-up is to take place, and the
time, if any is to be fixed, as of which the holders of record in respect of
such event are to be determined. Such notice shall be mailed at least 20 days
prior to the date specified in such notice on which any such action is to be
taken.

         13. ISSUE DATE. This Warrant is being issued by the Company on November
7, 2001 (the "Original Issue Date") in connection with that certain Asset
Purchase Agreement, dated as of November 7, 2001, among the Company, MMC/GATX
Partnership No. 1 and TransAmerica Technology Finance Corporation.

         14. AMENDMENT. The terms of this Warrant may be amended, modified or
waived only with the written consent of the Company and the Holder of this
Warrant.

         15. COMPLIANCE WITH THE SECURITIES ACT.

                  (a) COMPLIANCE WITH SECURITIES ACT. The Holder of this
Warrant, by acceptance hereof, agrees that this Warrant, and the shares of
Common Stock to be issued upon exercise hereof are being acquired for investment
and that such Holder will not offer, sell or otherwise dispose of this Warrant,
or any shares of Common Stock to be issued upon exercise hereof except under
circumstances which will not result in a violation of the Securities Act of
1933, as amended (the "Securities Act") or any applicable state securities laws.
Upon exercise of this Warrant, unless the Common Stock being acquired is
registered under the Securities Act and any applicable state securities laws or
an exemption from such registration is available, the holder hereof shall
confirm in writing that the shares of Common Stock so purchased (and any shares
issued upon conversion thereof) are being acquired for investment and not with a
view toward distribution or resale in violation of the Securities Act and shall
confirm such other matters related thereto as may be reasonably requested by the
Company. This Warrant and all shares of Common Stock issued upon exercise of
this Warrant (unless registered under the

<PAGE>

                                      -5-

Securities Act and any applicable state securities laws) shall be stamped or
imprinted with a legend in substantially the following form:

                  THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
                  REGISTERED UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN
                  ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN
                  CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH
                  SALE OR DISPOSITION MAY BE EFFECTED WITHOUT AN EFFECTIVE
                  REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF
                  COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH
                  REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933
                  AND APPLICABLE STATE SECURITIES LAWS.

Said legend shall be removed by the Company, upon the request of a holder, at
such time as the restrictions on the transfer of the applicable security shall
have terminated.

                  (b) In addition, in connection with the issuance of this
Warrant, the Holder specifically represents to the Company by acceptance of this
Warrant as follows:

                           (i) The Holder is aware of the Company's business
affairs and financial condition, and has acquired information about the Company
sufficient to reach an informed and knowledgeable decision to acquire this
Warrant. The Holder is acquiring this Warrant for its own account for investment
purposes only and not with a view to, or for the resale in connection with, any
"distribution" thereof in violation of the Securities Act or applicable state
securities laws.

                           (ii) The Holder understands that this Warrant has not
been registered under the Securities Act in reliance upon a specific exemption
therefrom, which exemption depends upon, among other things, the bona fide
nature of the Holder's investment intent as expressed herein.

                           (iii) The Holder further understands that this
Warrant must be held indefinitely unless subsequently registered under the
Securities Act and qualified under any applicable state securities laws, or
unless exemptions from registration and qualification are otherwise available.
The holder is aware of the provisions of Rule 144, promulgated under the
Securities Act.

         16. WARRANT REGISTER; TRANSFERS, ETC.

                  (a) Subject to the provisions of Section 15 hereto, this
Warrant and all rights hereunder are transferable (but only with all related
obligations) with the prior written consent of the Company, and upon surrender
of the Warrant with a properly executed assignment (in the

<PAGE>

                                      -6-

form attached hereto) at the principal office of the Company, or at such other
office or agency as the Company may designate.

                  (b) Each holder of this Warrant acknowledges that this Warrant
and the Common Stock of the Company issuable upon exercise hereof have not been
registered under the Securities Act, and agrees not to sell, pledge, distribute,
offer for sale, transfer or otherwise dispose of this Warrant or any Common
Stock issued upon its exercise in the absence of (i) an effective registration
statement under the Securities Act as to this Warrant or such Common Stock and
registration or qualification of this Warrant or such Common Stock under any
applicable blue sky or state securities law then in effect, or (ii) an opinion
of counsel, reasonably satisfactory to the Company, that such registration and
qualification are not required.

                  (c) Until any transfer of this Warrant is made in the warrant
register, the Company may treat the Holder of this Warrant as the absolute owner
hereof for all purposes; PROVIDED, HOWEVER, that if and when this Warrant is
properly assigned in accordance with this Section 16, the Company may (but shall
not be required to) treat the bearer hereof as the absolute owner hereof for all
purposes, notwithstanding any notice to the contrary. Except as otherwise
expressly provided herein, the provisions hereof shall inure to the benefit of,
and be binding upon, the successors, assigns, heirs, executors and
administrators of the parties hereto, as may be appropriate.

                  (d) The Company will maintain a register containing the names
and addresses of the registered holders of this Warrant. Any registered holder
may change such registered holder's address as shown on the warrant register by
written notice to the Company requesting such change.

         17. NO IMPAIRMENT. The Company will not, by amendment of its
Certificate of Incorporation or through any reclassification, capital
reorganization, consolidation, merger, sale or conveyance of assets,
dissolution, liquidation, issue or sale of securities or any other voluntary
action, avoid or seek to avoid the observance or performance of any of the terms
of this Warrant, but will at all times in good faith assist in the carrying out
of all such terms and in the taking of all such action as may be necessary or
appropriate in order to protect the rights of the Holder.

         18.      REGISTRATION RIGHTS.

                  (a) Whenever the Company proposes to file a registration
statement with the Securities and Exchange Commission for a public offering and
sale of securities of the Company (other than a registration statement on Form
S-8 or Form S-4, or their successors, or any other form for a limited purpose,
or any registration statement covering only securities proposed to be issued in
exchange for securities or assets of another corporation) (a "Registration
Statement"), it will, prior to such filing, give written notice to the Holder of
its intention to do so and, upon the written request of the Holder given within
30 days after the Company provides such notice, the Company shall use
commercially reasonable efforts to register under the Securities Act pursuant to
the Registration Statement all shares of Common Stock issued or issuable upon
conversion of the Warrant ("Registrable Shares") for which the Holder has
requested registration; provided that the Company shall have the right to
postpone or withdraw any registration effected pursuant to

<PAGE>

                                      -7-

this Section 18 without obligation to the Holder; and provided further that the
Company shall have no obligation to register Registrable Securities which have
already been registered under the Securities Act pursuant to an effective
registration statement or are owned by a Holder who could immediately sell all
of such Registrable Securities publicly pursuant to Rule 144 under the
Securities Act.

                  (b) In connection with any offering under this Section 18
involving an underwriting, the Company shall include in such offering all the
Registrable Shares specified in a written request or requests, mailed by the
Holder within 30 days of receipt of such written notice from the Company,
provided that the Company may limit, to the extent so advised by the
underwriters as a result of market conditions, the amount of Registrable Shares
to be included in the registration by the Holder to an amount not less than one
third of the total number of securities included in the offering. If the number
of Registrable Shares to be included in the underwriting in accordance with the
foregoing is less than the total number of Registrable Shares which the Holder
has requested to be included, then the Company may include all securities
proposed to be registered by the Company to be sold for its own account and the
Holder shall participate in the underwriting pro rata based upon its total
ownership of shares of Common Stock of the Company, together with any additional
holders of shares of the Company's capital stock who has requested registration
of any or all of such holder's shares pursuant to and in accordance with a grant
of registration rights by the Company (a "Selling Securityholder"). If any
Selling Securityholder would thus be entitled to include more shares than such
Selling Securityholder requested to be registered, the excess shall be allocated
among other requesting Selling Securityholders pro rata based upon their total
ownership of shares.

                  (c) A Holder proposing to distribute its securities in an
offering under this Section 18 involving an underwriting shall (together with
the Company and other shareholders of securities distributing their shares
through such underwriting) enter into an underwriting agreement in customary
form with the underwriter or underwriters selected for the underwriting.

                  (d) The Company shall not be obligated to register, pursuant
to this Section 18, the Registrable Shares of any Holder who fails to provide
promptly to the Company such information as the Company may reasonable request
at any time to enable the Company to comply with any applicable law or
regulation or to facilitate preparation of the Registration Statement.

         19. RULE 144 REPORTING. With a view to making available the benefits of
certain rules and regulations of the Securities and Exchange Commission which
may at any time permit the sale of the Registrable Shares to the public without
registration, the Company agrees to:

                  (a)  make and keep public information available, as those
terms are understood and defined in Rule 144 under the Securities Act;

                  (b) use commercially reasonable efforts to file with the
Securities and Exchange Commission in a timely manner all reports and other
documents required of the Company under the Securities Act and the Exchange Act
of 1934, as amended (the "Exchange Act"); and

<PAGE>

                                      -8-

                  (c) furnish to each holder of Registrable Shares forthwith
upon request a written statement by the Company as to its compliance with the
reporting requirements of such Rule 144 and of the Securities Act and the
Exchange Act, a copy of the most recent annual or quarterly report of the
Company, and such other reports and documents so filed by the Company as such
holder may reasonably request in availing itself of any rule or regulation of
the Securities and Exchange Commission allowing such holder to sell any
Registrable Shares without registration.

         20. GOVERNING LAW. The provisions and terms of this Warrant shall be
governed by and construed in accordance with the internal laws of the
Commonwealth of Massachusetts.

         21. SUCCESSORS AND ASSIGNS. This Warrant shall be binding upon the
Company's successors and assigns and shall inure to the benefit of the Holder's
successors, legal representatives and permitted assigns.

         22. BUSINESS DAYS. If the last or appointed day for the taking of any
action required or the expiration of any right granted herein shall be a
Saturday or Sunday or a legal holiday in the Commonwealth of Massachusetts, then
such action may be taken or right may be exercised on the next succeeding day
which is not a Saturday or Sunday or such a legal holiday.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

                                      -9-

Dated:  November 7, 2001              EXACT SCIENCES CORPORATION

(Corporate Seal)                      By:
                                         ---------------------------------------
                                      Name:
Attest:                               Title:

-----------------------------------

<PAGE>

                                      -10-

                                  Subscription

To:____________________             Date:_________________________

         The undersigned hereby subscribes for the shares of Common Stock
covered by this Warrant. The certificate(s) for such shares shall be issued in
the name of the undersigned or as otherwise indicated below:

                                    ---------------------------------------
                                    Signature

                                    ---------------------------------------
                                    Name for Registration

                                    ---------------------------------------
                                    Mailing Address

                            Net Issue Election Notice

To:____________________             Date:_________________________

         The undersigned hereby elects under Section 4 to surrender the right to
purchase the shares of Common Stock pursuant to this Warrant. The certificate(s)
for the shares issuable upon such net issue election shall be issued in the name
of the undersigned or as otherwise indicated below.

                                    ---------------------------------------
                                    Signature

                                    ---------------------------------------
                                    Name for Registration

                                    ---------------------------------------
                                    Mailing Address

<PAGE>

                                      -11-

                                   Assignment

         For value received ____________________________ hereby sells,

assigns and transfers unto ______________________________________

-----------------------------------------------------------------
    Please print or typewrite name and address of Assignee

-----------------------------------------------------------------

the within Warrant, and does hereby irrevocably constitute and appoint
_______________________ its attorney to transfer the within Warrant on the books
of the within named Company with full power of substitution on the premises.

Dated:_______________________

                                    ---------------------------------------

In the Presence of:

-----------------------------<PAGE>

                                                                 EXHIBIT 10.26

                   AMENDMENT NO. 1 TO SECURED PROMISSORY NOTE

This Amendment No. 1, dated as of November 30, 2001, is entered into by and
among Exact Sciences Corporation, a Delaware corporation (the "Company") and
Stanley N. Lapidus (the "Obligor").

WHEREAS, the Obligor entered into a Secured Promissory Note with the Company
dated as of March 31, 2000 (the "Note"), the provisions of which grant the
Company and the Obligor the right to amend the terms of the Note; and

         WHEREAS, in light of the decrease in market interest rates and to
encourage the Company's employees including the Obligor to remain in the employ
of the Company, the Company desires to amend the interest rate on the Note and
all other promissory notes issued by the Company's employees to the Company to
more closely reflect current market interest rates.

         NOW, THEREFORE, in consideration of the promises and the agreements
         herein contained, and intending to be bound hereby, the parties hereby
         agree as follows: The first sentence of the first paragraph of the Note
         shall be amended and restated in its entirety to read as follows:

         "For value received, the undersigned, Stanley N. Lapidus (the
         "Obligor") promises to pay to the order of EXACT Sciences Corporation,
         a Delaware corporation (the "Company"), at its principal office at 63
         Great Road, Maynard, Massachusetts 01754, or such other place as may be
         designated from time to time in writing by the Company, or its assigns,
         the principal sum of One Hundered Four Thousand Dollars and No Cents
         ($104,000), together with accrued interest on the unpaid principal
         balance hereunder at the rate of 5% per annum, payable as set forth
         below."

         In all other respects, the Note shall remain in full force and effect.

This Amendment No. 1 may be executed in any number of counterparts and by
different parties hereto in separate counterparts, with the same effect as if
all parties had signed the same document. All such counterparts shall be deemed
an original, shall be construed together and shall constitute one and the same
instrument.

                                  EXACT SCIENCES CORPORATION

                                  By:  /s/ Don M. Hardison
                                       -----------------------------------------
                                           Don M. Hardison
                                  Title:   Chief Executive Officer and President
ACKNOWLEDGED AND AGREED

/s/ Stanley N. Lapidus
----------------------------
    Stanley N. Lapidus

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00035-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00035-of-00352.parquet"}]]