Document:

EX-4.6

 Exhibit 4.6 

AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT 

This AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (the “Agreement”) is dated as of July 30, 2013, by and among
Dicerna Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and the persons identified on the signature pages hereto (the “Investors”). 

WHEREAS, the Company and certain Investors (the “Existing Investors”) entered into that certain Amended and Restated
Registration Rights Agreement dated as of October 14, 2010 (the “Prior Agreement”) in connection with the purchase by the Existing Investors of the Company’s Series B Preferred Stock, par value $0.0001 per share (the
“Series B Preferred Stock”); 
 WHEREAS, the Investors are purchasing, pursuant to the terms of that certain Series C
Preferred Stock Purchase Agreement dated as of the date hereof (the “Stock Purchase Agreement”), shares of the Company’s Series C Preferred Stock, par value $0.0001 per share (the “Series C Preferred Stock” and
together with the Series A Preferred Stock (as defined below) and the Series B Preferred Stock, the “Preferred Stock”); 

WHEREAS, the Company and the Existing Investors, representing an “Investor Majority” (as such term is defined in the Prior
Agreement) desire to amend and restate the Prior Agreement in its entirety and to accept the rights and obligations created pursuant hereto in lieu of the rights and obligations created under the Prior Agreement; 

WHEREAS, to induce the Investors to enter into the Stock Purchase Agreement and purchase shares of Series C Preferred Stock thereunder, the
Company and the Investors desire to enter into this Agreement to set forth certain rights and obligations of the Investors; and 
 WHEREAS,
it is a condition precedent to the obligations of the Investors under the Stock Purchase Agreement that this Agreement be executed by the parties hereto, and the parties are willing to execute this Agreement and be bound by the provisions hereof;

 NOW, THEREFORE, in consideration of the premises, as an inducement to the Investors to consummate the transactions contemplated by the
Stock Purchase Agreement, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Company and the Investors hereby covenant and agree that the Prior Agreement shall be amended and restated in
its entirety as follows. 
 1. Certain Definitions. As used in this Agreement, the following terms shall have the
following respective meanings. All other capitalized terms not defined herein shall have the respective meanings set forth in the Stock Purchase Agreement unless otherwise indicated. 

“Affiliate” means, with respect to any specified Person, any other Person who or which, directly or indirectly, controls, is
controlled by, or is under common control with such specified Person, including, without limitation, any general partner, officer, director or manager of such Person and any venture capital fund now or hereafter existing that is controlled by one or
more general partners or managing members of, or is under common investment management with, such Person. 

 “Commission” shall mean the United States Securities and Exchange Commission, or
any other federal agency administering the Securities Act and the Exchange Act at the time. 
 “Common Stock” shall mean
the Common Stock and any other common equity securities issued by the Company, and any other shares of stock issued or issuable with respect thereto (whether by way of a stock dividend or stock split or in exchange for or upon conversion of such
shares or otherwise in connection with a combination of shares, recapitalization, merger, consolidation or other corporate reorganization). 

“Exchange Act” shall mean the Securities Exchange Act of 1934, as amended, or any similar successor federal statute, and the
rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. 
 “Form S-1” means such form under the Securities Act as in effect on the date hereof or any successor registration form under the Securities Act subsequently adopted by the Commission. 

“Form S-3” means such form under the Securities Act as in effect on the date hereof
or any registration form under the Securities Act subsequently adopted by the SEC that permits incorporation of substantial information by reference to other documents filed by the Company with the Commission. 

“Initial Public Offering” shall mean the Company’s first public offering of shares of Common Stock under the Securities
Act. 
 “Investor Majority” shall mean the holders of not less than a majority of the issued and outstanding shares of
Preferred Stock, voting together as a single class and not as separate series, and on an as-converted basis, which majority shall include the holders of at least seventy-four percent (74%) of the issued and outstanding shares of Series C
Preferred Stock. 
 “Person” shall mean an individual, a corporation, a partnership, a joint venture, a trust, an
unincorporated organization, a limited liability company or partnership, a government and any agency or political subdivision thereof. 

“Qualified IPO” shall mean the closing of the sale of shares of Common Stock to the public (i) at a price of at least
$7.00 per share (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Common Stock) in a firm commitment underwritten public offering pursuant to an
effective registration statement under the Securities Act resulting in at least sixty million dollars ($60,000,000) of gross proceeds to the Company, prior to the deduction of underwriting discount and commissions, or (ii) any other public
offering or registration statement approved by (a) an Investor Majority and (b) the Company and the holders of at least a majority of the then issued and outstanding shares of Series C Preferred Stock. 

“Registrable Securities” shall mean (i) any shares of Common Stock issued or issuable upon conversion of the Preferred
Stock; (ii) any shares of Common Stock, or any shares of Common Stock issued or issuable (directly or indirectly) upon conversion and/or exercise of any other securities of the Company, held as of the date of this Agreement or hereafter
acquired by 

  
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the Investors; and (iii) any other securities issued and issuable with respect to any such shares described in clauses (i) and (ii) above by way of a stock dividend or stock split
or in connection with a combination of shares, recapitalization, merger, consolidation or other reorganization (it being understood that for purposes of this Agreement, a Person will be deemed to be a holder of Registrable Securities whenever such
Person has the right to then acquire or obtain from the Company any Registrable Securities, whether or not such acquisition has actually been effected). 

“Registration Expenses” shall mean the expenses so described in Section 6 hereof. 

“Required Holders” shall mean the holders of not less than two-thirds (2/3) of the issued and outstanding shares of
Registrable Securities. 
 “Securities Act” shall mean the Securities Act of 1933, as amended, or any similar successor
federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. 

“Series A Preferred Stock” shall mean the Company’s Series A Preferred Stock, par value $0.0001 per share. 

2. Demand Registration. 

(a) Any time after the earlier of (i) December 31, 2018 and (ii) 180 days after a Qualified IPO, an Investor Majority may
notify the Company in writing that they intend to offer or cause to be offered for public sale all or any portion of their Registrable Securities in the manner specified in such request. Upon receipt of such request, the Company shall promptly
deliver notice of such request to all Investors holding Registrable Securities who shall then have thirty (30) days to notify the Company in writing of their desire to be included in such registration. If the request for registration
contemplates an underwritten public offering, the Company shall state such in the written notice and in such event the right of any Person to participate in such registration shall be conditioned upon such Person’s participation in such
underwritten public offering and the inclusion of such Person’s Registrable Securities in the underwritten public offering to the extent provided herein. The Company will use its best efforts to expeditiously file a Form S-1 covering all
Registrable Securities whose holders request participation in such registration under the Securities Act, but only to the extent provided for in this Agreement; provided, however, that the Company shall not be required to effect or pay
for registration pursuant to a request under this Section 2 more than two (2) times. Notwithstanding anything to the contrary contained herein, no request may be made under this Section 2 within ninety (90) days
after the effective date of a registration statement filed by the Company covering a firm commitment underwritten public offering in which the holders of Registrable Securities shall have been entitled to join pursuant to Section 4 and
in which there shall have been effectively registered all Registrable Securities as to which registration shall have been requested. A registration will not count as a requested registration under this Section 2(a) unless and until the
registration statement relating to such registration has been declared effective by the Commission at the request of the initiating shareholders; provided, however, that the holders that participate in such registration pursuant to
this Section 2(a) and hold at least sixty percent (60%) of Registrable Securities (the “Withdrawing Holders”) may request, in writing, that the Company withdraw a registration statement which has been filed under
this Section 2(a) but has not yet 

  
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been declared effective, and the Withdrawing Holders may thereafter request the Company to reinstate such registration statement, if permitted under the Securities Act, or to file another
registration statement, in accordance with the procedures set forth herein and without reduction in the number of demand registrations permitted under this Section 2(a). 

(b) If a requested registration involves an underwritten public offering and the managing underwriter of such offering determines in good
faith that the number of securities sought to be offered should be limited due to market conditions, then the number of securities to be included in such underwritten public offering shall be reduced to a number deemed satisfactory by such managing
underwriter; provided, however, that the shares to be excluded shall be determined in the following order of priority: (i) persons not having any contractual or other right to include such securities in the registration statement,
(ii) securities held by any other Persons (other than the holders of Registrable Securities) having a contractual, incidental “piggy back” right to include such securities in the registration statement, (iii) securities to be
registered by the Company pursuant to such registration statement, (iv) Registrable Securities of holders who did not make the original request for registration and (v) Registrable Securities of holders who requested such registration
pursuant to Section 2(a). If there is a reduction of the number of Registrable Securities pursuant to clauses (iv) or (v), such reduction shall be made on a pro rata basis (based upon the aggregate number of Registrable Securities
held by such holders). 
 (c) With respect to a request for registration pursuant to Section 2(a) which is for an underwritten
public offering, the managing underwriter shall be chosen by the holders of two-thirds (2/3) in interest of the Registrable Securities to be sold in such offering (which approval will not be unreasonably withheld or delayed). The Company may
not cause any other registration of securities for sale for its own account (other than a registration effected solely to implement an employee benefit plan or a transaction to which Rule 145 of the Securities Act is applicable) to become effective
within one hundred twenty (120) days following the effective date of any registration required pursuant to this Section 2. 

3. Form S-3. After the first public offering of its securities registered under the Securities Act, the Company shall use its
best efforts to qualify and remain qualified to register securities pursuant to a registration statement on Form S-3 (or any successor form) under the Securities Act, holders of at least twenty-five percent (25%) of the Registrable Securities
shall have the right to request an unlimited number of registrations on Form S-3 (or any successor form) for such Registrable Securities, provided that, the anticipated aggregate sale price for such Registrable Securities (net of underwriting
discounts and commissions, if any) is in excess of $3,000,000. Such requests shall be in writing and shall state the number of shares of Registrable Securities to be disposed of and the intended method of disposition of such shares by such holder or
holders. The Company shall give notice to all other holders of the Registrable Securities of the receipt of a request for registration pursuant to this Section 3 and such holders of Registrable Securities shall then have thirty
(30) days to notify the Company in writing of their desire to participate in the registration. The Company shall use its best efforts to effect promptly the registration of all shares on Form S-3 (or a comparable successor form) to the extent
requested by such holders. The Company shall use its best efforts to keep such registration statement effective until the earlier of ninety (90) days after the effectiveness of the registration statement on Form S-3 or until such holders have
completed the distribution described in such registration statement. The Company shall be obligated to pay for no more than two (2) registrations of Registrable Securities on Form S-3 under this Section 3. 

  
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 4. Piggyback Registration. If the Company at any time proposes to register
any of its securities under the Securities Act for sale to the public (except with respect to registration statements on Forms S-4, S-8 or another form not available for registering the Registrable Securities for sale to the public), each such time
it will give written notice at the applicable address of record to each holder of Registrable Securities of its intention to do so. Upon the written request of any of such holders of the Registrable Securities, given within twenty (20) days
after receipt by such Person of such notice, the Company will, subject to the limits contained in this Section 4, use its best efforts to cause all such Registrable Securities of said requesting holders to be registered under the
Securities Act and qualified for sale under any state blue sky law, all to the extent required to permit such sale or other disposition of said Registrable Securities; provided, however, that if the Company is advised in writing in
good faith by any managing underwriter of the Company’s securities being offered in a public offering pursuant to such registration statement that the amount to be sold by Persons other than the Company (collectively, “Selling
Stockholders”) is greater than the amount which can be offered without adversely affecting the offering, the Company may reduce the amount offered for the accounts of Selling Stockholders (including such holders of shares of Registrable
Securities) to a number deemed satisfactory by such managing underwriter; and provided, further, that any shares to be excluded shall be determined in the following order of priority: (i) securities held by any Persons not having
any such contractual, incidental registration rights, (ii) securities held by any Persons having contractual, incidental registration rights pursuant to an agreement which is not this Agreement, and (iii) the Registrable Securities sought
to be included by the holders thereof as determined on a pro rata basis (based upon the aggregate number of Registrable Securities held by such holders). 

5. Registration Procedures. If and whenever the Company is required by the provisions of this Agreement to use its best
efforts to promptly effect the registration of any of its securities under the Securities Act, the Company will: 
 (a) use its best
efforts diligently to prepare and file with the Commission a registration statement on the appropriate form under the Securities Act with respect to such securities, which form shall comply as to form in all material respects with the requirements
of the applicable form and include all financial statements required by the Commission to be filed therewith, and use its best efforts to cause such registration statement to become and remain effective until completion of the proposed offering;

 (b) use its best efforts to diligently prepare and file with the Commission such amendments and supplements to such registration
statement and the prospectus used in connection therewith as may be necessary to keep such registration statement effective until the holder or holders have completed the distribution described in such registration statement and to comply with the
provisions of the Securities Act with respect to the sale or other disposition of all securities covered by such registration statement whenever the seller or sellers of such securities shall desire to sell or otherwise dispose of the same, but only
to the extent provided in this Agreement; 

  
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 (c) furnish to each selling holder and the underwriters, if any, such number of copies of such
registration statement, any amendments thereto, any documents incorporated by reference therein, the prospectus, including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents as such selling
holder may reasonably request in order to facilitate the public sale or other disposition of the securities owned by such selling holder; 

(d) use its best efforts to register or qualify the securities covered by such registration statement under such other securities or state
blue sky laws of such jurisdictions as each selling holder shall request, and do any and all other acts and things which may be necessary under such securities or blue sky laws to enable such selling holder to consummate the public sale or other
disposition in such jurisdictions of the securities owned by such selling holder, except that the Company shall not for any such purpose be required to qualify to do business as a foreign corporation in any jurisdiction wherein it is not so
qualified; 
 (e) within a reasonable time before each filing of the registration statement or prospectus or amendments or supplements
thereto with the Commission, furnish to one counsel selected by the holders of Registrable Securities included in the applicable registration copies of such documents proposed to be filed; 

(f) immediately notify each selling holder of Registrable Securities, such selling holder’s counsel and any underwriter and (if requested
by any such Person) confirm such notice in writing, of the happening of any event which makes any statement made in the registration statement or related prospectus untrue or which requires the making of any changes in such registration statement or
prospectus so that they will not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein in the light of the circumstances under which they were
made not misleading; and, as promptly as practicable thereafter, prepare and file with the Commission and furnish a supplement or amendment to such prospectus so that, as thereafter deliverable to the purchasers of such Registrable Securities, such
prospectus will not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading; 

(g) use its best efforts to prevent the issuance of any order suspending the effectiveness of a registration statement, and if one is issued
use its best efforts to obtain the withdrawal of any order suspending the effectiveness of a registration statement at the earliest possible moment; 

(h) if requested by the managing underwriter or underwriters (if any), any selling holder, or such selling holder’s counsel, promptly
incorporate in a prospectus supplement or post-effective amendment such information as such Person requests to be included therein, including, without limitation, with respect to the securities being sold by such selling holder to such underwriter
or underwriters, the purchase price being paid therefor by such underwriter or underwriters and with respect to any other terms of an underwritten offering of the securities to be sold in such offering, and promptly make all required filings of such
prospectus supplement or post-effective amendment; 

  
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 (i) make available to each selling holder, any underwriter participating in any disposition
pursuant to a registration statement, and any attorney, accountant or other agent or representative retained by any such selling holder or underwriter (collectively, the “Inspectors”), all financial and other records, pertinent
corporate documents and properties of the Company, as shall be reasonably necessary to enable them to exercise their due diligence responsibility, and cause the Company’s officers, directors and employees to supply all information requested by
any such Inspector in connection with such registration statement; 
 (j) enter into any reasonable underwriting agreement required by the
proposed underwriter(s) for the selling holders, if any, and use its best efforts to facilitate the public offering of the securities; 

(k) furnish to each prospective selling holder a signed counterpart, addressed to the prospective selling holder, of (A) an opinion of
counsel for the Company, dated the effective date of the registration statement, and (B) a “comfort” letter signed by the independent public accountants who have certified the Company’s financial statements included in the
registration statement, covering substantially the same matters with respect to the registration statement (and the prospectus included therein) and (in the case of the accountants’ letter) with respect to events subsequent to the date of the
financial statements, as are customarily covered (at the time of such registration) in opinions of the Company’s counsel and in accountants’ letters delivered to the selling holders or underwriters, as the case may be, in underwritten
public offerings of securities; 
 (l) cause the securities covered by such registration statement to be listed on the securities exchange
or quoted on the quotation system on which the Common Stock of the Company is then listed or quoted (or if the Common Stock is not yet listed or quoted, then on such exchange or quotation system as the selling holders of Registrable Securities and
the Company shall determine); 
 (m) otherwise cooperate with the underwriter(s), the Commission and other regulatory agencies and take all
actions and execute and deliver or cause to be executed and delivered all documents necessary to effect the registration of any securities under this Agreement; and 

(n) during the period when the prospectus is required to be delivered under the Securities Act, promptly file all documents required to be
filed with the Commission pursuant to Sections 13(a), 13(c), 14, or 15(d) of the Exchange Act. 
 6. Expenses. All expenses
incurred by the Company or the Investors in effecting the registrations provided for in Sections 2, 3 (in each case, with respect to two (2) registrations only) and 4, including, without limitation, all registration
and filing fees, printing expenses, fees and disbursements of counsel for the Company and one counsel for the Investors participating in such registration as a group (selected by the holders of at least two-thirds (2/3) in interest of
Registrable Securities who participate in the registration) (the “Selling Holder Counsel”), underwriting expenses (other than fees, commissions or discounts), expenses of any audits incident to or required by any such registration
and expenses of complying with the securities or blue sky laws of any jurisdictions (all of such expenses referred to as “Registration Expenses”), shall be paid by the Company. 

  
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 7. Indemnification. 

(a) The Company shall indemnify and hold harmless each Investor that is a selling holder of Registrable Securities, its partners (including
partners of partners and shareholders of such partners)), directors, officers, employees and agents, each underwriter (as defined in the Securities Act) for such selling holder, and each other Person, if any, who controls (within the meaning of the
Securities Act) such selling holder or underwriter (individually and collectively, the “Indemnified Person”) against any losses, claims, damages or liabilities (collectively, the “liability”), joint or several, to
which such Indemnified Person may become subject under Securities Act or any other statute or at common law, insofar as such liability (or action in respect thereof) arises out of or is based upon (i) any untrue statement or alleged untrue
statement of any material fact contained, on the effective date thereof, in any registration statement under which such securities were registered under the Securities Act, any preliminary prospectus or final prospectus contained therein, or any
amendment or supplement thereto, or (ii) any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, or (iii) any violation by the Company of
the Securities Act, any state securities or “blue sky” laws or any rule or regulation thereunder in connection with such registration. Except as otherwise provided in Section 7(d), the Company shall reimburse each such
Indemnified Person in connection with investigating or defending any such liability; provided, however, that the Company shall not be liable to any Indemnified Person in any such case to the extent that any such liability arises out of
or is based upon any untrue statement or alleged untrue statement or omission or alleged omission made in such registration statement, preliminary or final prospectus, or amendment or supplement thereto in reliance upon and in conformity with
information furnished in writing to the Company by such Person specifically for use therein; and provided, further, that the Company shall not be required to indemnify any Person against any liability arising from any untrue or
misleading statement or omission contained in any preliminary prospectus if such deficiency is corrected in the final prospectus or for any liability which arises out of the failure of any Person to deliver a prospectus as required by the Securities
Act regardless of any investigation made by or on behalf of such Indemnified Person and shall survive transfer of such securities by such seller. 

(b) Each Investor holding any securities included in such registration being effected, severally and not jointly, shall indemnify and hold
harmless each other selling holder of any securities included in such registration, the Company, its directors and officers, each underwriter and each other Person, if any, who controls (within the meaning of the Securities Act) the Company or such
underwriter (individually and collectively also the “Indemnified Person”), against any liability, joint or several, to which any such Indemnified Person may become subject under the Securities Act or any other statute or at common
law, insofar as such liability (or actions in respect thereof) arises out of or is based upon (i) any untrue statement or alleged untrue statement of any material fact contained, on the effective date thereof, in any registration statement
under which securities were registered under the Securities Act at the request of such selling Investor, any preliminary prospectus or final prospectus contained therein, or any amendment or supplement thereto, (ii) any omission or alleged
omission by such selling Investor to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, in the case of (i) and (ii) to the extent, but only to the extent,

  
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that such untrue statement or alleged untrue statement or omission or alleged omission was made in such registration statement, preliminary or final prospectus, amendment or supplement thereto in
reliance upon and in conformity with information furnished in writing to the Company by such selling Investor specifically for use therein, or (iii) any violation by such selling Investor of the Securities Act, any state securities or
“blue sky” laws or any rule or regulation thereunder in connection with such registration. Such selling Investor shall reimburse any Indemnified Person for any legal fees incurred in investigating or defending any such liability; provided,
however, that in no event shall the liability of any Investor for indemnification under this Section 7(b) in its capacity as a seller of Registrable Securities exceed the lesser of (i) that proportion of the total of such losses,
claims, damages, expenses or liabilities indemnified against equal to the proportion of the total securities sold under such registration statement which is being held by such Investor, or (ii) the amount equal to the net proceeds to such
Investor of the securities sold in any such registration; and provided further, however, that no selling Investor shall be required to indemnify any Person against any liability arising from any untrue or misleading statement or omission contained
in any preliminary prospectus if such deficiency is corrected in the final prospectus or for any liability which arises out of the failure of any Person to deliver a prospectus as required by the Securities Act. 

(c) Indemnification similar to that specified in Sections 7(a) and (b) shall be given by the Company and each selling
holder (with such modifications as may be appropriate) with respect to any required registration or other qualification of their securities under any federal or state law or regulation of governmental authority other than the Securities Act. 

(d) In the event the Company, any selling holder or other Person receives a complaint, claim or other notice of any liability or action,
giving rise to a claim for indemnification under Section 7(a), (b) or (c) above, the Person claiming indemnification under such paragraphs shall promptly notify in writing the Person against whom indemnification
is sought of such complaint, notice, claim or action, and such indemnifying Person shall have the right to investigate and defend any such loss, claim, damage, liability or action. 

(e) If the indemnification provided for in this Section 7 for any reason is held by a court of competent jurisdiction to be unavailable
to an Indemnified Person in respect of any losses, claims, damages, expenses or liabilities referred to therein, then each indemnifying party under this Section 7, in lieu of indemnifying such indemnified party thereunder, shall contribute to
the amount paid or payable by such indemnified party as a result of such losses, claims, damages, expenses or liabilities (i) in such proportion as is appropriate to reflect the relative benefits received by the Company, the Investor, or
Investors and the underwriters from the offering of Registrable Securities or (ii) if the allocation provided by clause (i) above is not permitted by applicable law, in such proportion as is appropriate to reflect not only the relative
benefits referred to in clause (i) above but also the relative fault of the Company, the other Investors and the underwriters in connection with the statements or omissions which resulted in such losses, claims, damages expenses or liabilities,
as well as any other relevant equitable considerations. The relative benefits received by the Company, the Investors and the underwriters shall be deemed to be in the same respective proportions that the net proceeds from the offering (before
deducting expenses) received by the Company, the Investors, and the underwriting discount received by the underwriters, in each case as set forth in the table on the cover page of the applicable prospectus, bear to the aggregate public offering
price of the 

  
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Registrable Securities. The relative fault of the Company, the Investors and the underwriters shall be determined by reference to, among other things, whether the untrue or alleged untrue
statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company, the Investors, or the underwriters and the parties’ relative intent, knowledge, access to information and
opportunity to correct or prevent such statement or omission. 
 The Company, the Investors and the underwriters agree that it would not be
just and equitable if contribution under this Section 7(e) were determined by pro rata or per capita allocation or by any other method of allocation which does not take account the equitable considerations referred to in the immediately
preceding paragraph. In no event, however, shall an Investor be required to contribute under this Section 7(e) in excess of the lesser of (i) that proportion of the total of such losses, claims, damages expenses or liabilities
indemnified against equal to the proportion of the total Registrable Securities sold under such registration statement which are being sold by such Investor or (ii) the net proceeds received by such Investor from its sale of Registrable
Securities under such registration statement. No Person found guilty of fraudulent representation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not found guilty of such
fraudulent misrepresentation. 
 (f) The amount paid by an indemnifying party or payable to an Indemnified Person as a result of the losses,
claims, damages, expenses and liabilities referred to in this Section 7 shall be deemed to include, subject to limitations set forth above, any legal or other expenses reasonably incurred by such indemnified party in connection with
investigating or defending any such action or claim, payable as the same are incurred. The indemnification and contribution provided for in this Section 7 will remain in full force and effect regardless of any investigation made by or on behalf
of the indemnified parties or any other officer, director, employee, agent or controlling person of the indemnified parties. No indemnifying party, in the defense of any such claim or litigation, shall enter into a consent or entry of any judgment
or enter into a settlement without the consent of the Indemnified Person, which consent will not be unreasonably withheld or delayed. 

8. Compliance with Rule 144. In the event that the Company (i) registers a class of securities under Section 12
of the Exchange Act or (ii) shall commence to file reports under Section 13 or 15(d) of the Exchange Act, the Company will use its best efforts thereafter to file with the Commission such information as is required under the Exchange Act
for so long as there are holders of Registrable Securities; and in such event, the Company shall use its best efforts to take all action as may be required as a condition to the availability of Rule 144 under the Securities Act (or any comparable
successor rules). The Company shall furnish to any holder of Registrable Securities upon request a written statement executed by the Company as to the steps it has taken to comply with the current public information requirement of Rule 144 (or such
comparable successor rules). After the occurrence of the first underwritten public offering of Common Stock of the Company pursuant to an offering registered under the Securities Act on Form S-1 (or any comparable successor form), subject to the
limitations on transfers imposed by this Agreement, the Company shall use its best efforts to facilitate and expedite transfers of Registrable Securities pursuant to Rule 144 under the Securities Act, which efforts shall include timely notice to its
transfer agent to expedite such transfers of Registrable Securities. 

  
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 9. Rule 144A Information. The Company shall, upon written request of any
Investor, provide to such Investor and to any prospective institutional transferee of the Common Stock designated by such Investor, such financial and other information as is available to the Company or can be obtained by the Company without
material expense and as such Investor may reasonably determine is required to permit such transfer to comply with the requirements of Rule 144A promulgated under the Securities Act. 

10. Amendments. The provisions of this Agreement may be amended or waived, and the Company may take any action herein
prohibited or omit to perform any act herein required to be performed by it, only with the prior written consent of the Company and an Investor Majority. For the purposes of this Agreement and all agreements executed pursuant hereto, no course of
dealing between or among any of the parties hereto and no delay on the part of any party hereto in exercising any rights hereunder or thereunder shall operate as a waiver of the rights hereof and thereof. 

11. Postponement. The Company may postpone the filing of any registration statement required hereunder for a reasonable period
of time, not to exceed ninety (90) days in the aggregate during any twelve-month period, if the Company has been advised by legal counsel that such filing would require a special audit or the disclosure of a material impending transaction or
other matter and the Company’s Board of Directors determines reasonably and in good faith that such disclosure would have a material adverse effect on the Company (a “Black-Out Period”). Upon notice of the existence of a
Black-Out Period from the Company to any Investor or Investors with respect to any registration statement already effective, such Investor or Investors shall refrain from selling their Registrable Securities under such registration statement until
such Black-Out Period has ended; provided, however, that the Company shall not impose a Black-Out Period with respect to any registration statement that is already effective more than twice during any period of twelve
(12) consecutive months and in no event shall such Black-Out Period exceed sixty (60) days. 
 12. Market Stand-Off.
Each Investor agrees that, if requested by the Company and an underwriter of Registrable Securities of the Company in connection with the Initial Public Offering of the Company, not to directly or indirectly offer, sell, contract to sell, sell any
option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant for the sale of or otherwise dispose of or transfer any shares held by it for such period not to exceed one hundred eighty (180) days
following the effective date of the relevant registration statement filed under the Securities Act in connection with the Initial Public Offering, plus such additional period of time as may be required to comply with Financial Industry Regulatory
Authority Marketplace Rule 2711 or similar rules thereto, as such underwriter shall specify reasonably and in good faith; provided, however, that all officers and directors of the Company and all one percent (1%) or greater
stockholders of the Company enter into similar agreements. 
 13. Transferability of Registration Rights. The
registration rights set forth in this Agreement are transferable to each transferee of Registrable Securities. Each subsequent holder of Registrable Securities must consent in writing to be bound by the terms and conditions of this Agreement in
order to acquire the rights granted pursuant to this Agreement. 

  
 11 

 14. Rights Which May Be Granted to Subsequent Investors. From and after the
date of this Agreement, the Company shall not, without the prior written consent of the Required Holders, enter into any agreement with any holder or prospective holder of any securities of the Company that would allow such holder or prospective
holder (a) to include any of such securities in any registration filed under Section 2, Section 3 or Section 4, unless under the terms of such agreement, such holder or prospective holder may include such
securities in any such registration only to the extent that the inclusion of such securities will not reduce the amount of Registrable Securities of the holders that are included or (b) to demand registration of their securities. 

15. Damages. The Company recognizes and agrees that each holder of Registrable Securities will not have an adequate
remedy if the Company fails to comply with the terms and provisions of this Agreement and that damages will not be readily ascertainable, and the Company expressly agrees that, in the event of such failure, it shall not oppose an application by any
holder of Registrable Securities or any other Person entitled to the benefits of this Agreement requiring specific performance of any and all provisions hereof or enjoining the Company from continuing to commit any such breach of this Agreement.

 16. Termination of Registration Rights. The rights to request registration or inclusion of Registrable Securities in
any registration pursuant to the terms of this Agreement shall terminate upon the earliest to occur of: 
 (a) the closing of a Deemed
Liquidation Event, as such term is defined in the Company’s Amended and Restated Certificate of Incorporation, as such may be amended from time to time; 

(b) as to any holder of Registrable Securities, such earlier time after the Initial Public Offering at which such holder (i) can sell all
shares held by it in compliance with Rule 144(b)(1)(i); or (ii) holds one percent (1%) or less of the Company’s outstanding Common Stock and all Registrable Securities held by such holder (together with any Affiliate of the
holder with which such holder must aggregate its sales under Rule 144) can be sold in any three (3) month period without registration in compliance with Rule 144; and 

(c) the fifth (5th) anniversary of the Initial Public Offering. 

17. Miscellaneous. 

(a) Notices. All notices, requests, demands and other communications provided for hereunder shall be in writing and mailed (by first
class registered or certified mail, postage prepaid), sent by express overnight courier service or electronic facsimile transmission (with a copy by mail), or delivered to the applicable party at the addresses indicated below. 

If to the Company: 

Dicerna Pharmaceuticals, Inc. 

480 Arsenal Street 
 Building 1,
Suite 120 
 Watertown MA 02472 

Attn: Douglas Fambrough, Ph.D., CEO 

Facsimile: (617) 252-0927 

  
 12 

 With a copy to: 

O’Melveny & Myers LLP 

2765 Sand Hill Road 
 Menlo Park,
CA 94025 
 Attn: Sam Zucker, Esq. 

Facsimile: (650) 473-2601 

If to the Investors: 
 To
the address set forth below such party’s signature hereto; 
 With a copy to: 

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, PC 

One Financial Center 
 Boston, MA
02111 
 Attn: William C. Hicks, Esq. 

Facsimile: (617) 542-2241 

If to any other holder of Registrable Securities: 

At such Person’s address for notice as set forth in the books and records of the Company; 

or, as to each of the foregoing, at such other address as shall be designated by such Person in a written notice to the other parties complying as to delivery
with the terms of this subsection (a). All such notices, requests, demands and other communications shall, when mailed or sent, respectively, be effective (i) two (2) days after being deposited in the mails or (ii) one (1) day
after being delivered to the telegraph company, deposited with the express overnight courier service or sent by electronic facsimile transmission, respectively, addressed as aforesaid. 

(b) Governing Law. This Agreement shall be governed by and construed in accordance with the internal laws of the State of Delaware,
without giving effect to any choice of law rule that would cause the application of the laws of any jurisdiction other than the internal laws of the State of Delaware to the rights and duties of the parties. 

(c) Dispute Resolution. 

(i) All disputes, claims or controversies arising out of or relating to this Agreement or any other agreement executed and delivered pursuant
to this Agreement or the negotiation, validity or performance hereof and thereof or the transactions contemplated hereby and thereby that are not resolved by mutual agreement shall be resolved solely and exclusively by binding arbitration to be
conducted before J.A.M.S./Endispute, Inc., or its successor (“JAMS”). The arbitration shall be held in Boston, Massachusetts before a single arbitrator mutually agreeable to the Company and the holders of two-thirds (2/3) of
the voting power of the Registrable Securities and if no agreement can be reached within thirty (30) days after names of 

  
 13 

 
potential arbitrators have been proposed by JAMS, then by one arbitrator having reasonable experience in corporate finance transactions of the type provided for in this Agreement and who is
chosen by JAMS. The arbitration shall be conducted in accordance with the rules and regulations promulgated by JAMS unless specifically modified herein. 

The parties covenant and agree that the arbitration shall commence within sixty (60) days of the date on which a written demand for
arbitration is filed by any party hereto. In connection with the arbitration proceeding, the arbitrator shall have the power to order the production of documents by each party and any third party witnesses. However, the arbitrator shall not have the
power to order the answering of interrogatories or the response to requests for admission. In connection with any arbitration, each party shall provide to the other, no later than seven (7) business days before the date of the arbitration, the
identity of all persons that may testify at the arbitration, a copy of all documents that may be introduced at the arbitration or considered or used by a party’s witness or expert, and a summary of the expert’s opinions and basis for said
opinions. The arbitrator’s decision and award shall be made and delivered to the parties to such dispute, claim or controversy within thirty (30) days of the conclusion of the arbitration. The arbitrator’s written decision shall set
forth a reasoned basis for any award of damages or finding of liability. The arbitrator shall not have power to award damages in excess of actual compensatory damages and shall not multiply actual damages or award punitive damages or any other
damages that are specifically excluded under this Agreement, and each party hereby irrevocably waives any claim to such damages. 
 The
parties covenant and agree that they will participate in the arbitration in good faith and that they will share equally its costs, except as otherwise provided herein. The arbitrator shall assess costs and expenses (including the reasonable legal
fees and expenses of the prevailing party) against any party to a proceeding that did not prevail. Any party refusing to comply with an order of the arbitrators shall be liable for costs and expenses, including attorneys’ fees, incurred by the
other party in enforcing the award. This Section applies equally to requests for temporary, preliminary or permanent injunctive relief, except that in the case of temporary or preliminary injunctive relief any party may proceed in court without
prior arbitration for the limited purpose of avoiding immediate and irreparable harm. The provisions of this Section shall be enforceable in any court of competent jurisdiction. 

Subject to the second sentence of the immediately preceding paragraph, the parties shall bear their own attorneys’ fees, costs and
expenses in connection with the arbitration. The parties will share equally in the fees and expenses charged by JAMS. 
 (ii) Each of the
parties hereto irrevocably and unconditionally consents to the exclusive jurisdiction of JAMS to resolve all disputes, claims or controversies arising out of or relating to this Agreement or any other agreement executed and delivered pursuant to
this Agreement or the negotiation, validity or performance hereof and thereof or the transactions contemplated hereby and thereby and further consents to the jurisdiction of the courts of Boston, Massachusetts for the purposes of enforcing the
arbitration provisions of paragraph (c)(i) above. Each party further irrevocably waives any objection to proceeding before JAMS based upon lack of personal jurisdiction or to the laying of venue and further irrevocably and unconditionally waives and
agrees not to make a claim in any court that arbitration before JAMS has been brought in an inconvenient forum. Each of the parties hereto hereby consents to service of 

  
 14 

 
process by registered mail at the address to which notices are to be given. Each of the parties hereto agrees that its or his submission to jurisdiction and its or his consent to service of
process by mail is made for the express benefit of the other parties hereto. 
 (d) Counterparts. This Agreement may be executed in
two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (e-mail) or other transmission method and any
counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. 
 (e)
Severability. If any provision of this Agreement shall be held to be illegal, invalid or unenforceable, such illegality, invalidity or unenforceability shall attach only to such provision and shall not in any manner affect or render illegal,
invalid or unenforceable any other provision of this Agreement, and this Agreement shall be carried out as if any such illegal, invalid or unenforceable provision were not contained herein. 

(f) Aggregation of Stock. All shares of Registrable Securities held or acquired by affiliated entities (including affiliated venture
capital funds or venture capital funds under common investment management) or Persons shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 

(g) Integration. This Agreement, including the exhibits, documents and instruments referred to herein or therein, constitutes the
entire agreement among the parties with respect to the subject matter. 
 (h) Prior Agreement. The Company and the Investors party to
the Prior Agreement (which parties hold the requisite percentages to amend the Prior Agreement by written consent) hereby amend and restate the Prior Agreement in its entirety and the Prior Agreement shall have no further force or effect. 

[SIGNATURE PAGES FOLLOW] 

  
 15 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	COMPANY
	
	DICERNA PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Douglas Fambrough

	Name:	 	Douglas Fambrough, Ph.D.
	Title:	 	President and Chief Executive Officer

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	DOMAIN PARTNERS VIII, L.P.
		
	By:	 	One Palmer Square Associates VIII, L.L.C.
		 	its General Partner
		
	By:	 	 /s/ Kathleen K. Schoemaker

		 	Kathleen K. Schoemaker
		 	Managing Member
		
		 	DP VIII ASSOCIATES, L.P.
		
	By:	 	One Palmer Square Associates VIII, L.L.C.
		 	its General Partner
		
	By:	 	 /s/ Kathleen K. Schoemaker

		 	Kathleen K. Schoemaker
		 	Managing Member

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	 INVESTOR
  

OXFORD BIOSCIENCE PARTNERS V L.P.

		
	By:	 	OBP Management V L.P.
		
	By:	 	 /s/ Jonathan J. Fleming

		
	Name:	 	Jonathan Fleming
	Title:	 	General Partner
	
	mRNA Fund V L.P.
		
	By:	 	OBP Management V L.P.
		
	By:	 	 /s/ Jonathan J. Fleming

	Name:	 	Jonathan Fleming
	Title:	 	General Partner

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	SKYLINE VENTURE PARTNERS V, L.P.
		
	By:	 	Skyline Venture Management V LLC
		
	By:	 	 /s/ Kerensa Kenny

		
	Name:	 	 Kerensa Kenny

	Title:	 	 Authorized Signer

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	ABINGWORTH BIOVENTURES V LP
		
	By:	 	Abingworth LLP, its Manager
		
	By:	 	 /s/ T. J. Haines

		
	Name:	 	 T. J. Haines

	Title:	 	 Partner

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	S.R. ONE, LIMITED
		
	By:	 	 /s/ Brian M. Gallagher

		
	Name:	 	 Brian M. Gallagher, Jr. PhD.

	Title:	 	 Vice President & Partner

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

	
	INVESTOR
	
	 /s/ Roberto Guerciolini

	Roberto Guerciolini

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

					
	INVESTOR:
	
	LANGER FAMILY HOLDINGS, LLLP
	By:	 	Langer Family Investments, LLC
		
	By:	 	 /s/ Dennis H. Langer

		 	Name:	 	Dennis H. Langer, M.D.
		 	Title:	 	Managing Member

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	HERCULES TECHNOLOGY II, L.P.
		
	By:	 	Hercules Technology SBIC Management, LLC, its general partner
		
	By:	 	Hercules Technology Growth Capital, Inc., its Manager
		
	By:	 	 /s/ K. Nicholas Martitsch

	Name:	 	 K. Nicholas Martitsch

	Title:	 	 Associate General Counsel

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	 ALEXANDRIA EQUITIES, LLC,
 a
Delaware limited liability company

	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, INC., a Maryland corporation, managing member
		
	By:	 	 /s/ Dean A. Shlgenaga

	Name:	 	 Dean A. Shlgenaga

	Title:	 	 Executive Vice President

		 	 Chief Financial Officer

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

									
	INVESTOR
	
	DEERFIELD SPECIAL SITUATIONS FUND, L.P.
	By:	 	Deerfield Mgmt, L.P.
		 	General Partner
	By:	 	J.E. Flynn Capital, LLC
		 	General Partner
				
		 		 	By:	 	 /s/ David J. Clark

		 		 		 	Name:	 	David J. Clark
		 		 		 	Title:	 	Authorized Signatory
	
	DEERFIELD SPECIAL SITUATIONS FUND INTERNATIONAL MASTER FUND, L.P.
	By:	 	Deerfield Mgmt, L.P.
		 	General Partner
		 	By:	 	J.E. Flynn Capital, LLC
		 		 	General Partner
				
		 		 	By:	 	 /s/ David J. Clark

		 		 		 	Name:	 	David J. Clark
		 		 		 	Title:	 	Authorized Signatory
	
	DEERFIELD PRIVATE DESIGN FUND II, L.P.
	By:	 	Deerfield Mgmt, L.P.
		 	General Partner
		 	By:	 	J.E. Flynn Capital, LLC
		 		 	General Partner
				
		 		 	By:	 	 /s/ David J. Clark

		 		 		 	Name:	 	David J. Clark
		 		 		 	Title:	 	Authorized Signatory
	
	DEERFIELD PRIVATE DESIGN INTERNATIONAL II, L.P.
	By:	 	Deerfield Mgmt, L.P.
		 	General Partner
		 	By:	 	J.E. Flynn Capital, LLC
		 		 	General Partner
				
		 		 	By:	 	 /s/ David J. Clark

		 		 		 	Name:	 	David J. Clark
		 		 		 	Title:	 	Authorized Signatory

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

					
	INVESTOR
	
	BROOKSIDE CAPITAL PARTNERS FUND, L.P.
		
	By:	 	Brookside Capital Investors, L.P.
		 	Its general partner
		
	By:	 	 /s/ Adam M. Koppel

		 	Name:	 	 Adam M. Koppel

		 	Title:	 	 Managing Director

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	OMEGA FUND IV, L.P.
	By:	 	Omega Fund IV GP, L.P.
		 	its General Partner
	By:	 	Omega Fund IV GP Manager, Ltd.
		 	its General Partner
		
	By:	 	 /s/ A-M. Paster

	Name:	 	 A-M. Paster

	Director

  
 [Signature Page to
Amended and Restated Registration Rights Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated Registration Rights
Agreement to be duly executed as of the date first set forth above. 
  

			
	INVESTOR
	
	RA Capital Healthcare Fund, LP
	
	 /s/ Peter Kolchinsky

	By:	 	Peter Kolchinsky
	Title:	 	Manager

  
 [Signature Page to
Amended and Restated Registration Rights Agreement]EX-10.1

 Exhibit 10.1 

DICERNA PHARMACEUTICALS, INC. 

THIRD AMENDED AND RESTATED 

2007 EMPLOYEE, DIRECTOR AND CONSULTANT STOCK PLAN 

This Dicerna Pharmaceuticals, Inc. Third Amended and Restated 2007 Employee, Director and Consultant Stock Plan was duly adopted by the Board
of Directors and stockholders of Dicerna Pharmaceuticals, Inc. (the “Company”) on July 8, 2008, and amends, restates and supersedes in its entirety the Dicerna Pharmaceuticals, Inc. Second Amended and Restated 2007 Employee, Director
and Consultant Stock Plan adopted by the Board of Directors and stockholders of the Company on November 13, 2007. 
  

	1.	DEFINITIONS. 

 Unless otherwise specified or unless the context otherwise requires, the
following terms, as used in this Dicerna Pharmaceuticals, Inc. Third Amended and Restated 2007 Employee, Director and Consultant Stock Plan, have the following meanings: 

Administrator means the Board of Directors, unless it has delegated power to act on its behalf to the Committee, in which case the
Administrator means the Committee. 
 Affiliate means a corporation which, for purposes of Section 424 of the Code, is a parent
or subsidiary of the Company, direct or indirect. 
 Board of Directors means the Board of Directors of the Company. 

Code means the United States Internal Revenue Code of 1986, as amended. 

Committee means the committee of the Board of Directors to which the Board of Directors has delegated power to act under or pursuant to
the provisions of the Plan. 
 Common Stock means shares of the Company’s common stock, $0.0001 par value per share. 

Company means Dicerna Pharmaceuticals, Inc. a Delaware corporation. 

Disability or Disabled means permanent and total disability as defined in Section 22(e)(3) of the Code. 

Employee means any employee of the Company or of an Affiliate (including, without limitation, an employee who is also serving as an
officer or director of the Company or of an Affiliate), designated by the Administrator to be eligible to be granted one or more Stock Rights under the Plan. 

  
 1 

 Fair Market Value of a Share of Common Stock means: 

(1) If the Common Stock is listed on a national securities exchange or traded in the over-the-counter market and sales prices are regularly reported for the Common Stock, the closing or last price of the Common Stock on the Composite Tape or other comparable reporting system for the trading
day immediately preceding the applicable date; 
 (2) If the Common Stock is not traded on a national securities exchange but is traded on
the over-the-counter market, if sales prices are not regularly reported for the Common Stock for the trading day referred to in clause (1), and if bid and asked
prices for the Common Stock are regularly reported, the mean between the bid and the asked price for the Common Stock at the close of trading in the over-the-counter
market for the trading day on which Common Stock was traded immediately preceding the applicable date; and 
 (3) If the Common Stock is
neither listed on a national securities exchange nor traded in the over-the-counter market, such value as the Administrator, in good faith, shall determine. 

ISO means an option meant to qualify as an incentive stock option under Section 422 of the Code. 

Non-Qualified Option means an option which is not intended to qualify as an ISO. 

Option means an ISO or Non-Qualified Option granted under the Plan. 

Option Agreement means an agreement between the Company and a Participant delivered pursuant to the Plan, in such form as the
Administrator shall approve. 
 Participant means an Employee, director or consultant of the Company or an Affiliate to whom one or
more Stock Rights are granted under the Plan. As used herein, “Participant” shall include “Participant’s Survivors” where the context requires. 

Plan means this Dicerna Pharmaceuticals, Inc. Third Amended and Restated 2007 Employee, Director and Consultant Stock Plan. 

Shares means shares of the Common Stock as to which Stock Rights have been or may be granted under the Plan or any shares of capital
stock into which the Shares are changed or for which they are exchanged within the provisions of Paragraph 3 of the Plan. The Shares issued upon exercise of Options granted under the Plan may be authorized and unissued shares or shares held by
the Company in its treasury, or both. 
 Stock Grant means a grant by the Company of Shares under the Plan. 

  
 2 

 Stock Grant Agreement means an agreement between the Company and a Participant delivered
pursuant to the Plan, in such form as the Administrator shall approve. 
 Stock Right means a right to Shares of the Company granted
pursuant to the Plan — an ISO, a Non-Qualified Option or a Stock Grant. 
 Survivor means
a deceased Participant’s legal representatives and/or any person or persons who acquired the Participant’s rights to an Option by will or by the laws of descent and distribution. 

 

	2.	PURPOSES OF THE PLAN. 

 The Plan is intended to encourage ownership of Shares by
Employees and directors of and certain consultants to the Company in order to attract such people, to induce them to work for the benefit of the Company or of an Affiliate and to provide additional incentive for them to promote the success of the
Company or of an Affiliate. The Plan provides for the granting of ISOs, Non-Qualified Options and Stock Grants. 
  

	3.	SHARES SUBJECT TO THE PLAN. 

 (a) The number of Shares which may be issued from time to
time pursuant to this Plan shall be 6,000,000, or the equivalent of such number of Shares after the Administrator, in its sole discretion, has interpreted the effect of any stock split, stock dividend, combination, recapitalization or similar
transaction in accordance with Paragraph 16 of the Plan. 
 If an Option ceases to be “outstanding”, in whole or in part, or
if the Company shall require any Shares pursuant to a Stock Grant, the Shares which were subject to such Option and any Shares so reacquired by the Company shall be available for the granting of other Stock Rights under the Plan. Any Option shall be
treated as “outstanding” until such Option is exercised in full, or terminates or expires under the provisions of the Plan, or by agreement of the parties to the pertinent Option Agreement. 

 

	4.	ADMINISTRATION OF THE PLAN. 

 The Administrator of the Plan will be the Board of
Directors, except to the extent the Board of Directors delegates its authority to the Committee, in which case the Committee shall be the Administrator. Subject to the provisions of the Plan, the Administrator is authorized to: 

 

	 	a.	Interpret the provisions of the Plan or of any Option or Stock Grant and to make all rules and determinations which it deems necessary or advisable for the administration of the Plan; 

 

	 	b.	Determine which Employees, directors and consultants shall be granted Stock Rights; 

  

	 	c.	Determine the number of Shares for which a Stock Rights or Stock Rights shall be granted;. 

  
 3 

	 	d.	Specify the terms and conditions upon which a Stock Right or Stock Rights may be granted; and 

  

	 	e.	Adopt any sub-plans applicable to residents of any specified jurisdiction as it deems necessary or appropriate in order to comply with or take advantage of any tax laws applicable
to the Company or to Plan Participants or to otherwise facilitate the administration of the Plan, which sub-plans may include additional restrictions or conditions applicable to Options or Shares acquired upon
exercise of Options. 

 provided, however, that all such interpretations, rules, determinations, terms and conditions shall be made and
prescribed in the context of preserving the tax status under Section 422 of the Code of those Options which are designated as ISOs. Subject to the foregoing, the interpretation and construction by the Administrator of any provisions of the Plan
or of any Stock Right granted under it shall be final, unless otherwise determined by the Board of Directors, if the Administrator is the Committee. In addition, if the Administrator is the Committee, the Board of Directors may take any action under
the Plan that would otherwise be the responsibility of the Committee. 
 If permissible under applicable law, the Board of Directors or the
Committee may allocate all or any portion of its responsibilities and powers to any one or more of its members and may delegate all or any portion of its responsibilities and powers to any other person selected by it. Any such allocation or
delegation may be revoked by the Board of Directors or the Committee at any time. 
  

	5.	ELIGIBILITY FOR PARTICIPATION. 

 The Administrator will, in its sole discretion, name the
Participants in the Plan, provided, however, that each Participant must be an Employee, director or consultant of the Company or of an Affiliate at the time a Stock Right is granted. Notwithstanding the foregoing, the Administrator may authorize the
grant of a Stock Right to a person not then an Employee, director or consultant of the Company or of an Affiliate; provided, however, that the actual grant of such Stock Right shall be conditioned upon such person becoming eligible to become a
Participant at or prior to the time of the execution of the Agreement evidencing such Stock Right. ISOs may be granted only to Employees. Non-Qualified Options and Stock Grants may be granted to any Employee,
director or consultant of the Company or an Affiliate. The granting of any Stock Right to any individual shall neither entitle that individual to, nor disqualify him or her from, participation in any other grant of Stock Rights. 

  
 4 

	6.	TERMS AND CONDITIONS OF OPTIONS. 

 Each Option shall be set forth in writing in an Option
Agreement, duly executed by the Company and, to the extent required by law or requested by the Company, by the Participant. The Administrator may provide that Options be granted subject to such terms and conditions, consistent with the terms and
conditions specifically required under this Plan, as the Administrator may deem appropriate including, without limitation, subsequent approval by the shareholders of the Company of this Plan or any amendments thereto. The Option Agreements shall be
subject to at least the following terms and conditions: 
  

	 	A.	Non-Qualified Options: Each Option intended to be a Non-Qualified Option shall be subject to the terms and conditions which the
Administrator determines to be appropriate and in the best interest of the Company, subject to the following minimum standards for any such Non-Qualified Option: 

 

	 	a.	Option Price: Each Option Agreement shall state the option price (per share) of the Shares covered by each Option, which option price shall be determined by the Administrator but shall not be less than $0.0001 per share
of Common Stock; 

  

	 	b.	Each Option Agreement shall state the number of Shares to which it pertains; 

  

	 	c.	Each Option Agreement shall state the date or dates on which it first is exercisable and the date after which it may no longer be exercised, and may provide that the Option rights accrue or become exercisable in
installments over a period of months or years, or upon the occurrence of certain conditions or the attainment of stated goals or events; and 

  

	 	d.	Exercise of any Option may be conditioned upon the Participant’s execution of a Share purchase agreement in form satisfactory to the Administrator providing for certain protections for the Company and its other
shareholders, including requirements that: 

  

	 	i.	The Participant’s or the Participant’s Survivors’ right to sell or transfer the Shares may be restricted; and 

  

	 	ii.	The Participant or the Participant’s Survivors may be required to execute letters of investment intent and must also acknowledge that the Shares will bear legends noting any applicable restrictions.

  

	 	B.	ISOs: Each Option intended to be an ISO shall be issued only to an Employee and be subject to the following terms and conditions, with such additional restrictions or changes as the Administrator determines are
appropriate but not in conflict with Section 422 of the Code and relevant regulations and rulings of the Internal Revenue Service: 

  

	 	a.	Minimum standards: The ISO shall meet the minimum standards required of Non-Qualified Options, as described in Paragraph 6(A) above, except clause (a) thereunder.

  
 5 

	 	b.	Option Price: Immediately before the ISO is granted, if the Participant owns, directly or by reason of the applicable attribution rules in Section 424(d) of the Code: 

 

	 	i.	10% or less of the total combined voting power of all classes of stock of the Company or an Affiliate, the Option price per share of the Shares covered by each ISO shall not be less than 100% of the Fair Market
Value per share of the Shares on the date of the grant of the Option; or 

  

	 	ii.	More than 10% of the total combined voting power of all classes of stock of the Company or an Affiliate, the Option price per share of the Shares covered by each ISO shall not be less than 110% of the said Fair Market
Value on the date of grant. 

  

	 	c.	Term of Option: For Participants who own: 

  

	 	i.	10% or less of the total combined voting power of all classes of stock of the Company or an Affiliate, each ISO shall terminate not more than ten years from the date of the grant or at such earlier time as the
Option Agreement may provide; or 

  

	 	ii.	More than 10% of the total combined voting power of all classes of stock of the Company or an Affiliate, each ISO shall terminate not more than five years from the date of the grant or at such earlier time as the Option
Agreement may provide. 

  

	 	d.	Limitation on Yearly Exercise: The Option Agreements shall restrict the amount of ISOs which may become exercisable in any calendar year (under this or any other ISO plan of the Company or an Affiliate) so that the
aggregate Fair Market Value (determined at the time each ISO is granted) of the stock with respect to which ISOs are exercisable for the first time by the Participant in any calendar year does not exceed $100,000. 

 

	7.	TERMS AND CONDITIONS OF STOCK GRANTS. 

 Each offer of a Stock Grant to a Participant
shall state the date prior to which the Stock Grant must be accepted by the Participant, and the principal terms of each Stock Grant shall be set forth in a Stock Grant Agreement, duly executed by the Company and, to the extent required by law or
requested by the Company, by the Participant. The Stock Grant Agreement shall be in a form approved by the Administrator and shall contain terms and conditions which the Administrator determines to be appropriate and in the best interest of the
Company, subject to the following minimum standards: 
  

	 	(a)	Each Stock Grant Agreement shall state the purchase price (per share), if any, of the Shares covered by each Stock Grant, which purchase price shall be determined by the Administrator but shall not be less than the
minimum consideration required by the Delaware General Corporation Law on the date of the grant of the Stock Grant; 

  
 6 

	 	(b)	Each Stock Grant Agreement shall state the number of Shares to which the Stock Grant pertains; and 

  

	 	(c)	Each Stock Grant Agreement shall include the terms of any right of the Company to restrict or reacquire the Shares subject to the Stock Grant, including the time and events upon which such reacquisition rights shall
accrue and the purchase price therefor, if any. 

  

	8.	EXERCISE OF OPTIONS AND ISSUE OF SHARES. 

 An Option (or any part or installment thereof)
shall be exercised by giving written notice to the Company or its designee, together with provision for payment of the full purchase price in accordance with this Paragraph for the Shares as to which the Option is being exercised, and upon
compliance with any other condition(s) set forth in the Option Agreement. Such notice shall be signed by the person exercising the Option, shall state the number of Shares with respect to which the Option is being exercised and shall contain any
representation required by the Plan or the Option Agreement. Payment of the purchase price for the Shares as to which such Option is being exercised shall be made (a) in United States dollars in cash or by check, or (b) at the discretion
of the Administrator, through delivery of shares of Common Stock having a Fair Market Value equal as of the date of the exercise to the cash exercise price of the Option and held for at least six months, or (c) at the discretion of the
Administrator, by delivery of the grantee’s personal note, for full, partial or no recourse, bearing interest payable not less than annually at no less than 100% of the applicable Federal rate, as defined in Section 1274(d) of the Code,
with or without the pledge of such Shares as collateral, or (d) at the discretion of the Administrator, in accordance with a cashless exercise program established with a securities brokerage firm, and approved by the Administrator, or
(e) at the discretion of the Administrator, by any combination of (a), (b), (c) and (d) above. Notwithstanding the foregoing, the Administrator shall accept only such payment on exercise of an ISO as is permitted by Section 422
of the Code. 
 The Company shall then reasonably promptly deliver the Shares as to which such Option was exercised to the Participant (or
to the Participant’s Survivors, as the case may be). In determining what constitutes “reasonably promptly,” it is expressly understood that the issuance and delivery of the Shares may be delayed by the Company in order to comply with
any law or regulation (including, without limitation, state securities or “blue sky” laws) which requires the Company to take any action with respect to the Shares prior to their issuance. The Shares shall, upon delivery, be evidenced by
an appropriate certificate or certificates for fully paid, non-assessable Shares. 
 The
Administrator shall have the right to accelerate the date of exercise of any installment of any Option; provided that the Administrator shall not accelerate the exercise date of any installment of any Option granted to an Employee as an ISO (and not
previously converted into a Non-Qualified Option pursuant to Paragraph 19) if such acceleration would violate the annual vesting limitation contained in Section 422(d) of the Code, as described in
Paragraph 6.B.d. 

  
 7 

 The Administrator may, in its discretion, amend any term or condition of an outstanding Option
provided (i) such term or condition as amended is permitted by the Plan, (ii) any such amendment shall be made only with the consent of the Participant to whom the Option was granted, or in the event of the death of the Participant, the
Participant’s Survivors, if the amendment is adverse to the Participant, and (iii) any such amendment of any ISO shall be made only after the Administrator determines whether such amendment would constitute a “modification” of
any Option which is an ISO (as that term is defined in Section 424(h) of the Code) or would cause any adverse tax consequences for the holder of such ISO. 
  

	9.	ACCEPTANCE OF STOCK GRANT AND ISSUE OF SHARES. 

 A Stock Grant (or any part or
installment thereof) shall be accepted by executing the Stock Grant Agreement and delivering it to the Company or its designee, together with provision for payment of the full purchase price, if any, in accordance with this Paragraph for the Shares
as to which such Stock Grant is being accepted, and upon compliance with any other conditions set forth in the Stock Grant Agreement. Payment of the purchase price for the Shares as to which such Stock Grant is being accepted shall be made
(a) in United States dollars in cash or by check, or (b) at the discretion of the Administrator, through delivery of shares of Common Stock held for at least six months and having a Fair Market Value equal as of the date of acceptance of
the Stock Grant to the purchase price of the Stock Grant, or (c) at the discretion of the Administrator, by delivery of the grantee’s personal note, for full or partial recourse as determined by the Administrator, bearing interest payable
not less than annually at no less than 100% of the applicable Federal rate, as defined in Section 1274(d) of the Code, or (d) at the discretion of the Administrator, by any combination of (a), (b) and (c) above. 

The Company shall then reasonably promptly deliver the Shares as to which such Stock Grant was accepted to the Participant (or to the
Participant’s Survivors, as the case may be), subject to any escrow provision set forth in the Stock Grant Agreement. In determining what constitutes “reasonably promptly,” it is expressly understood that the issuance and delivery of
the Shares may be delayed by the Company in order to comply with any law or regulation (including, without limitation, state securities or “blue sky” laws) which requires the Company to take any action with respect to the Shares prior to
their issuance. 
 The Administrator may, in its discretion, amend any term or condition of an outstanding Stock Grant or Stock Grant
Agreement provided (i) such term or condition as amended is permitted by the Plan, and (ii) any such amendment shall be made only with the consent of the Participant to whom the Stock Grant was made, if the amendment is adverse to the
Participant. 
  

	10.	RIGHTS AS A SHAREHOLDER. 

 No Participant to whom a Stock Right has been granted shall
have rights as a shareholder with respect to any Shares covered by such Stock Right, except after due exercise of the Option or acceptance of the Stock Grant and tender of the full purchase price, if any, for the Shares being purchased pursuant to
such exercise or acceptance and registration of the Shares in the Company’s share register in the name of the Participant. 

  
 8 

	11.	ASSIGNABILITY AND TRANSFERABILITY OF OPTIONS. 

 By its terms, a Stock Right granted to a
Participant shall not be transferable by the Participant other than (i) by will or by the laws of descent and distribution, or (ii) as approved by the Administrator in its discretion and set forth in the applicable Option Agreement or
Stock Grant Agreement. Notwithstanding the foregoing, an ISO transferred except in compliance with clause (i) above shall no longer qualify as an ISO. The designation of a beneficiary of a Stock Right by a Participant, with the prior approval
of the Administrator and in such form as the Administrator shall prescribe, shall not be deemed a transfer prohibited by this Paragraph. Except as provided above, a Stock Right shall be exercisable or may be accepted, during the Participant’s
lifetime, only by such Participant (or by his or her legal representative) and shall not be assigned, pledged or hypothecated in any way (whether by operation of law or otherwise) and shall not be subject to execution, attachment or similar process.
Any attempted transfer, assignment, pledge, hypothecation or other disposition of any Stock Right or of any rights granted thereunder contrary to the provisions of this Plan, or the levy of any attachment or similar process upon a Stock Right, shall
be null and void. 
  

	12.	EFFECT OF TERMINATION OF SERVICE OTHER THAN “FOR CAUSE” OR DEATH OR DISABILITY. 

Except as otherwise provided in a Participant’s Option Agreement, in the event of a termination of service (whether as an employee,
director or consultant) with the Company or an Affiliate before the Participant has exercised an Option, the following rules apply: 
  

	 	a.	A Participant who ceases to be an employee, director or consultant of the Company or of an Affiliate (for any reason other than termination “for cause”, Disability, or death for which events there are special
rules in Paragraphs 13, 14 and 15, respectively), may exercise any Option granted to him or her to the extent that the Option is exercisable on the date of such termination of service, but only within such term as the Administrator has designated in
a Participant’s Option Agreement. 

  

	 	b.	Except as provided in Subparagraph (c) below, or Paragraph 14 or 15, in no event may an Option intended to be an ISO, be exercised later than three months after the Participant’s termination of
employment. 

  

	 	c.	The provisions of this Paragraph, and not the provisions of Paragraph 14 or 15, shall apply to a Participant who subsequently becomes Disabled or dies after the termination of employment, director status or
consultancy, provided, however, in the case of a Participant’s Disability or death within three months after the termination of employment, director status or consultancy, the Participant or the Participant’s Survivors may exercise the
Option within one year after the date of the Participant’s termination of service, but in no event after the date of expiration of the term of the Option. 

  
 9 

	 	d.	Notwithstanding anything herein to the contrary, if subsequent to a Participant’s termination of employment, termination of director status or termination of consultancy, but prior to the exercise of an Option, the
Board of Directors determines that, either prior or subsequent to the Participant’s termination, the Participant engaged in conduct which would constitute “cause”, then such Participant shall forthwith cease to have any right to
exercise any Option. 

  

	 	e.	A Participant to whom an Option has been granted under the Plan who is absent from work with the Company or with an Affiliate because of temporary disability (any disability other than a permanent and total Disability
as defined in Paragraph 1 hereof), or who is on leave of absence for any purpose, shall not, during the period of any such absence, be deemed, by virtue of such absence alone, to have terminated such Participant’s employment, director
status or consultancy with the Company or with an Affiliate, except as the Administrator may otherwise expressly provide. 

  

	 	f.	Except as required by law or as set forth in a Participant’s Option Agreement, Options granted under the Plan shall not be affected by any change of a Participant’s status within or among the Company and any
Affiliates, so long as the Participant continues to be an employee, director or consultant of the Company or any Affiliate. 

  

	13.	EFFECT ON OPTIONS OF TERMINATION OF SERVICE “FOR CAUSE”. 

 Except as otherwise
provided in a Participant’s Option Agreement, the following rules apply if the Participant’s service (whether as an employee, director or consultant) with the Company or an Affiliate is terminated “for cause” prior to the time
that all his or her outstanding Options have been exercised: 
  

	 	a.	All outstanding and unexercised Options as of the time the Participant is notified his or her service is terminated “for cause” will immediately be forfeited. 

 

	 	b.	For purposes of this Plan, “cause” shall include (and is not limited to) dishonesty with respect to the Company or any Affiliate, insubordination, substantial malfeasance or
non-feasance of duty, unauthorized disclosure of confidential information, breach by the Participant of any provision of any employment, consulting, advisory, nondisclosure,
non-competition or similar agreement between the Participant and the Company or any Affiliate, and conduct substantially prejudicial to the business of the Company or any Affiliate. The determination of the
Administrator as to the existence of “cause” will be conclusive on the Participant and the Company. 

  
 10 

	 	c.	“Cause” is not limited to events which have occurred prior to a Participant’s termination of service, nor is it necessary that the Administrator’s finding of “cause” occur prior to
termination. If the Administrator determines, subsequent to a Participant’s termination of service but prior to the exercise of an Option, that either prior or subsequent to the Participant’s termination the Participant engaged in conduct
which would constitute “cause,” then the right to exercise any Option is forfeited. 

  

	14.	EFFECT ON OPTIONS OF TERMINATION OF SERVICE FOR DISABILITY. 

 Except as otherwise
provided in a Participant’s Option Agreement, a Participant who ceases to be an employee, director or consultant of the Company or of an Affiliate by reason of Disability may exercise any Option granted to such Participant: 

 

	 	a.	To the extent that the Option has become exercisable but has not been exercised on the date of Disability; and 

  

	 	b.	In the event rights to exercise the Option accrue periodically, to the extent of a pro rata portion through the date of Disability of any additional vesting rights that would have accrued on the next vesting date had
the Participant not become Disabled. The proration shall be based upon the number of days accrued in the current vesting period prior to the date of Disability. 

A Disabled Participant may exercise such rights only within the period ending one year after the date of the Participant’s termination of
employment, directorship or consultancy, as the case may be, notwithstanding that the Participant might have been able to exercise the Option as to some or all of the Shares on a later date if the Participant had not become Disabled and had
continued to be an employee, director or consultant or, if earlier, within the originally prescribed term of the Option. 
 The
Administrator shall make the determination both of whether Disability has occurred and the date of its occurrence (unless a procedure for such determination is set forth in another agreement between the Company and such Participant, in which case
such procedure shall be used for such determination). If requested, the Participant shall be examined by a physician selected or approved by the Administrator, the cost of which examination shall be paid for by the Company. 

 

	15.	EFFECT ON OPTIONS OF DEATH WHILE AN EMPLOYEE, DIRECTOR OR CONSULTANT. 

 Except as
otherwise provided in a Participant’s Option Agreement, in the event of the death of a Participant while the Participant is an employee, director or consultant of the Company or of an Affiliate, such Option may be exercised by the
Participant’s Survivors: 
  

	 	a.	To the extent that the Option has become exercisable but has not been exercised on the date of death; and 

  
 11 

	 	b.	In the event rights to exercise the Option accrue periodically, to the extent of a pro rata portion through the date of death of any additional vesting rights that would have accrued on the next vesting date had the
Participant not died. The proration shall be based upon the number of days accrued in the current vesting period prior to the Participant’s date of death. 

If the Participant’s Survivors wish to exercise the Option, they must take all necessary steps to exercise the Option within one year
after the date of death of such Participant, notwithstanding that the decedent might have been able to exercise the Option as to some or all of the Shares on a later date if he or she had not died and had continued to be an employee, director or
consultant or, if earlier, within the originally prescribed term of the Option. 
  

	16.	EFFECT OF TERMINATION OF SERVICE ON STOCK GRANTS. 

 In the event of a termination of
service (whether as an employee, director or consultant) with the Company or an Affiliate for any reason before the Participant has accepted a Stock Grant, such offer shall terminate. 

For purposes of this Paragraph 16 and Paragraph 17 below, a Participant to whom a Stock Grant has been offered and accepted under
the Plan who is absent from work with the Company or with an Affiliate because of temporary disability (any disability other than a permanent and total Disability as defined in Paragraph 1 hereof), or who is on leave of absence for any purpose,
shall not, during the period of any such absence, be deemed, by virtue of such absence alone, to have terminated such Participant’s employment, director status or consultancy with the Company or with an Affiliate, except as the Administrator
may otherwise expressly provide. 
 In addition, for purposes of this Paragraph 16 and Paragraph 17 below, any change of
employment or other service within or among the Company and any Affiliates shall not be treated as a termination of employment, director status or consultancy so long as the Participant continues to be an employee, director or consultant of the
Company or any Affiliate. 
  

	17.	EFFECT ON STOCK GRANTS OF TERMINATION OF SERVICE OTHER THAN “FOR CAUSE” OR DEATH OR DISABILITY. 

Except as otherwise provided in a Participant’s Stock Grant Agreement, in the event of a termination of service (whether as an employee,
director or consultant), other than termination “for cause,” Disability, or death for which events there are special rules in Paragraphs 18, 19, and 20, respectively, before all Company rights of repurchase shall have lapsed, then the
Company shall have the right to repurchase that number of Shares subject to a Stock Grant as to which the Company’s repurchase rights have not lapsed. 
  

	18.	EFFECT ON STOCK GRANTS OF TERMINATION OF SERVICE “FOR CAUSE”. 

 Except as
otherwise provided in a Participant’s Stock Grant Agreement, the following rules apply if the Participant’s service (whether as an employee, director or consultant) with the Company or an Affiliate is terminated “for cause”: 

 

	 	a.	All Shares subject to any Stock Grant shall be immediately subject to repurchase by the Company at the lesser of (A) the Fair Market Value of the Shares determined in accordance with the Plan as of the date of
termination of service, and (B) the Purchase Price, if any, thereof. 

  
 12 

	 	b.	For purposes of this Plan, “cause” shall include (and is not limited to) dishonesty with respect to the employer, insubordination, substantial malfeasance or
non-feasance of duty, unauthorized disclosure of confidential information, breach by the Participant of any provision of any employment, consulting, advisory, nondisclosure,
non-competition or similar agreement between the Participant and the Company or any Affiliate, and conduct substantially prejudicial to the business of the Company or any Affiliate. The determination of the
Administrator as to the existence of “cause” will be conclusive on the Participant and the Company. 

  

	 	c.	“Cause” is not limited to events which have occurred prior to a Participant’s termination of service, nor is it necessary that the Administrator’s finding of “cause” occur prior to
termination. If the Administrator determines, subsequent to a Participant’s termination of service, that either prior or subsequent to the Participant’s termination the Participant engaged in conduct which would constitute
“cause,” then the Company’s right to repurchase all of such Participant’s Shares shall apply. 

  

	 	d.	Any definition in an agreement between the Participant and the Company or an Affiliate, which contains a conflicting definition of “cause” for termination and which is in effect at the time of such
termination, shall supersede the definition in this Plan with respect to that Participant. 

  

	19.	EFFECT ON STOCK GRANTS OF TERMINATION OF SERVICE FOR DISABILITY. 

 Except as otherwise
provided in a Participant’s Stock Grant Agreement, the following rules apply if a Participant ceases to be an employee, director or consultant of the Company or of an Affiliate by reason of Disability: to the extent the Company’s rights of
repurchase have not lapsed on the date of Disability, they shall be exercisable; provided, however, that in the event such rights of repurchase lapse periodically, such rights shall lapse to the extent of a pro rata portion of the Shares subject to
such Stock Grant through the date of Disability as would have lapsed had the Participant not become Disabled. The proration shall be based upon the number of days accrued prior to the date of Disability. 

The Administrator shall make the determination both of whether Disability has occurred and the date of its occurrence (unless a procedure for
such determination is set forth in another agreement between the Company and such Participant, in which case such procedure shall be used for such determination). If requested, the Participant shall be examined by a physician selected or approved by
the Administrator, the cost of which examination shall be paid for by the Company. 

  
 13 

	20.	EFFECT ON STOCK GRANTS OF DEATH WHILE AN EMPLOYEE, DIRECTOR OR CONSULTANT. 

 Except as
otherwise provided in a Participant’s Stock Grant Agreement, the following rules apply in the event of the death of a Participant while the Participant is an employee, director or consultant of the Company or of an Affiliate: to the extent the
Company’s rights of repurchase have not lapsed on the date of death, they shall be exercisable; provided, however, that in the event such rights of repurchase lapse periodically, such rights shall lapse to the extent of a pro rata portion of
the Shares subject to such Stock Grant through the date of death as would have lapsed had the Participant not died. The proration shall be based upon the number of days accrued prior to the Participant’s death. 

 

	21.	PURCHASE FOR INVESTMENT. 

 Unless the offering and sale of the Shares to be issued upon
the particular exercise of an Option shall have been effectively registered under the Securities Act of 1933, as now in force or hereafter amended (the “1933 Act”), the Company shall be under no obligation to issue the Shares covered by
such exercise unless and until the following conditions have been fulfilled: 
  

	 	a.	The person(s) who exercise(s) or accept(s) such Stock Right shall warrant to the Company, prior to the receipt of such Shares, that such person(s) are acquiring such Shares for their own respective accounts, for
investment, and not with a view to, or for sale in connection with, the distribution of any such Shares, in which event the person(s) acquiring such Shares shall be bound by the provisions of the following legend which shall be endorsed upon the
certificate(s) evidencing their Shares issued pursuant to such exercise or such grant: 

 “The shares represented by this
certificate have been taken for investment and they may not be sold or otherwise transferred by any person, including a pledgee, unless (1) either (a) a Registration Statement with respect to such shares shall be effective under the
Securities Act of 1933, as amended, or (b) the Company shall have received an opinion of counsel satisfactory to it that an exemption from registration under such Act is then available, and (2) there shall have been compliance with all
applicable state securities laws.” 
  

	 	b.	At the discretion of the Administrator, the Company shall have received an opinion of its counsel that the Shares may be issued upon such particular exercise or acceptance in compliance with the 1933 Act without
registration thereunder. 

  

	22.	DISSOLUTION OR LIQUIDATION OF THE COMPANY. 

 Upon the dissolution or liquidation of the
Company, all Options granted under this Plan which as of such date shall not have been exercised and all Stock Grants which have not been accepted will terminate and become null and void; provided, however, that if the rights of a

  
 14 

 
Participant or a Participant’s Survivors have not otherwise terminated and expired, the Participant or the Participant’s Survivors will have the right immediately prior to such
dissolution or liquidation to exercise or accept any Stock Right to the extent that the Stock Right is exercisable or subject to acceptance as of the date immediately prior to such dissolution or liquidation. 

 

	23.	ADJUSTMENTS. 

 Upon the occurrence of any of the following events, a Participant’s
rights with respect to any Stock Right granted to him or her hereunder which has not previously been exercised in full shall be adjusted as hereinafter provided, unless otherwise specifically provided in the Participant’s Option Agreement or
Stock Grant Agreement: 
 A. Stock Dividends and Stock Splits. If (i) the shares of Common Stock shall be subdivided or combined
into a greater or smaller number of shares or if the Company shall issue any shares of Common Stock as a stock dividend on its outstanding Common Stock, or (ii) additional shares or new or different shares or other securities of the Company or
other non-cash assets are distributed with respect to such shares of Common Stock, the number of shares of Common Stock deliverable upon the exercise or acceptance of such Stock Right may be appropriately
increased or decreased proportionately, and appropriate adjustments may be made in the purchase price per share to reflect such events. The number of Shares subject to the limitation in Paragraph 4(c) shall also be proportionately adjusted upon
the occurrence of such events. 
 B. Corporate Transactions. If the Company is to be consolidated with or acquired by another entity
in a merger, sale of all or substantially all of the Company’s assets other than a transaction to merely change the state of incorporation (a “Corporate Transaction”), the Administrator or the board of directors of any entity assuming
the obligations of the Company hereunder (the “Successor Board”), shall, as to outstanding Options, either (i) make appropriate provision for the continuation of such Options by substituting on an equitable basis for the Shares then
subject to such Options either the consideration payable with respect to the outstanding shares of Common Stock in connection with the Corporate Transaction or securities of any successor or acquiring entity; or (ii) upon written notice to the
Participants, provide that all Options must be exercised (either to the extent then exercisable or, at the discretion of the Administrator or, upon a change of control of the Company, all Options being made fully exercisable for purposes of this
Subparagraph), within a specified number of days of the date of such notice, at the end of which period the Options shall terminate; or (iii) terminate all Options in exchange for a cash payment equal to the excess of the Fair Market Value of
the Shares subject to such Options (either to the extent then exercisable or, at the discretion of the Administrator, all Options being made fully exercisable for purposes of this Subparagraph) over the exercise price thereof. 

With respect to outstanding Stock Grants, the Administrator or the Successor Board, shall either (i) make appropriate provisions for the
continuation of such Stock Grants by substituting on an equitable basis for the Shares then subject to such Stock Grants either the consideration payable with respect to the outstanding Shares of Common Stock in connection with the Corporate
Transaction or securities of any successor or acquiring entity; or (ii) upon written 

  
 15 

 
notice to the Participants, provide that all Stock Grants must be accepted (to the extent then subject to acceptance) within a specified number of days of the date of such notice, at the end of
which period the offer of the Stock Grants shall terminate; or (iii) terminate all Stock Grants in exchange for a cash payment equal to the excess of the Fair Market Value of the Shares subject to such Stock Grants over the purchase price
thereof, if any. In addition, in the event of a Corporate Transaction, the Administrator may waive any or all Company repurchase rights with respect to outstanding Stock Grants. 

C. Recapitalization or Reorganization. In the event of a recapitalization or reorganization of the Company other than a Corporate
Transaction pursuant to which securities of the Company or of another corporation are issued with respect to the outstanding shares of Common Stock, a Participant upon exercising or accepting a Stock Right after the recapitalization or
reorganization shall be entitled to receive for the purchase price paid upon such exercise or acceptance the number of replacement securities which would have been received if such Stock Right Option had been exercised or accepted prior to such
recapitalization or reorganization. 
 D. Modification of ISOs. Notwithstanding the foregoing, any adjustments made pursuant to
Subparagraph A, B or C above with respect to ISOs shall be made only after the Administrator determines whether such adjustments would constitute a “modification” of such ISOs (as that term is defined in Section 424(h) of the
Code) or would cause any adverse tax consequences for the holders of such ISOs. If the Administrator determines that such adjustments made with respect to ISOs would constitute a modification of such ISOs, it may refrain from making such
adjustments, unless the holder of an ISO specifically requests in writing that such adjustment be made and such writing indicates that the holder has full knowledge of the consequences of such “modification” on his or her income tax
treatment with respect to the ISO. 
  

	24.	ISSUANCES OF SECURITIES. 

 Except as expressly provided herein, no issuance by the
Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares subject to Stock Rights. Except as
expressly provided herein, no adjustments shall be made for dividends paid in cash or in property (including without limitation, securities) of the Company prior to any issuance of Shares pursuant to a Stock Right. 

 

	25.	FRACTIONAL SHARES. 

 No fractional shares shall be issued under the Plan and the person
exercising a Stock Right shall receive from the Company cash in lieu of such fractional shares equal to the Fair Market Value thereof. 
  

	26.	CONVERSION OF ISOs INTO NON-QUALIFIED OPTIONS; TERMINATION OF ISOs. 

The Administrator, at the written request of any Participant, may in its discretion take such actions as may be necessary to convert such
Participant’s ISOs (or any portions thereof) 

  
 16 

 
that have not been exercised on the date of conversion into Non-Qualified Options at any time prior to the expiration of such ISOs, regardless of whether
the Participant is an employee of the Company or an Affiliate at the time of such conversion. At the time of such conversion, the Administrator (with the consent of the Participant) may impose such conditions on the exercise of the resulting Non-Qualified Options as the Administrator in its discretion may determine, provided that such conditions shall not be inconsistent with this Plan. Nothing in the Plan shall be deemed to give any Participant the
right to have such Participant’s ISOs converted into Non-Qualified Options, and no such conversion shall occur until and unless the Administrator takes appropriate action. The Administrator, with the
consent of the Participant, may also terminate any portion of any ISO that has not been exercised at the time of such conversion. 
  

	27.	WITHHOLDING. 

 In the event that any federal, state, or local income taxes, employment
taxes, Federal Insurance Contributions Act (“F.I.C.A.”) withholdings or other amounts are required by applicable law or governmental regulation to be withheld from the Participant’s salary, wages or other remuneration in connection
with the exercise or acceptance of a Stock Right or in connection with a Disqualifying Disposition (as defined in Paragraph 28) or upon the lapsing of any right of repurchase, the Company may withhold from the Participant’s compensation,
if any, or may require that the Participant advance in cash to the Company, or to any Affiliate of the Company which employs or employed the Participant, the statutory minimum amount of such withholdings unless a different withholding arrangement,
including the use of shares of the Company’s Common Stock or a promissory note, is authorized by the Administrator (and permitted by law). For purposes hereof, the fair market value of the shares withheld for purposes of payroll withholding
shall be determined in the manner provided in Paragraph 1 above, as of the most recent practicable date prior to the date of exercise. If the fair market value of the shares withheld is less than the amount of payroll withholdings required, the
Participant may be required to advance the difference in cash to the Company or the Affiliate employer. The Administrator in its discretion may condition the exercise of an Option for less than the then Fair Market Value on the Participant’s
payment of such additional withholding. 
  

	28.	NOTICE TO COMPANY OF DISQUALIFYING DISPOSITION. 

 Each Employee who receives an ISO must
agree to notify the Company in writing immediately after the Employee makes a Disqualifying Disposition of any shares acquired pursuant to the exercise of an ISO. A Disqualifying Disposition is defined in Section 424(c) of the Code and includes
any disposition (including any sale or gift) of such shares before the later of (a) two years after the date the Employee was granted the ISO, or (b) one year after the date the Employee acquired Shares by exercising the ISO, except as
otherwise provided in Section 424(c) of the Code. If the Employee has died before such stock is sold, these holding period requirements do not apply and no Disqualifying Disposition can occur thereafter. 

 

	29.	TERMINATION OF THE PLAN. 

 The Plan will terminate on July 1, 2017, the date which
is ten years from the earlier of the date of its adoption by the Board of Directors and the date of its approval by the shareholders. The Plan may be terminated at an earlier date by vote of the shareholders or the Board of

  
 17 

 
Directors of the Company; provided, however, that any such earlier termination shall not affect any Option Agreements or Stock Grant Agreements executed prior to the effective date of such
termination. 
  

	30.	AMENDMENT OF THE PLAN AND AGREEMENTS. 

 The Plan may be amended by the shareholders of
the Company. The Plan may also be amended by the Administrator, including, without limitation, to the extent necessary to qualify any or all outstanding Stock Rights granted under the Plan or Stock Rights to be granted under the Plan for favorable
federal income tax treatment (including deferral of taxation upon exercise) as may be afforded incentive stock options under Section 422 of the Code, and to the extent necessary to qualify the shares issuable upon exercise or acceptance of any
outstanding Stock Rights granted, or Stock Rights to be granted, under the Plan for listing on any national securities exchange or quotation in any national automated quotation system of securities dealers. Any amendment approved by the
Administrator which the Administrator determines is of a scope that requires shareholder approval shall be subject to obtaining such shareholder approval. Any modification or amendment of the Plan shall not, without the consent of a Participant,
adversely affect his or her rights under a Stock Right previously granted to him or her. With the consent of the Participant affected, the Administrator may amend outstanding Option Agreements and Stock Grant Agreements in a manner which may be
adverse to the Participant but which is not inconsistent with the Plan. In the discretion of the Administrator, outstanding Option Agreements and Stock Grant Agreements may be amended by the Administrator in a manner which is not adverse to the
Participant. 
  

	31.	EMPLOYMENT OR OTHER RELATIONSHIP. 

 Nothing in this Plan or any Option Agreement or Stock
Grant Agreement shall be deemed to prevent the Company or an Affiliate from terminating the employment, consultancy or director status of a Participant, nor to prevent a Participant from terminating his or her own employment, consultancy or director
status or to give any Participant a right to be retained in employment or other service by the Company or any Affiliate for any period of time. 
  

	32.	GOVERNING LAW. 

 This Plan shall be construed and enforced in accordance with the law of
the State of Delaware. 

  
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