Document:

Employee Stock Purchase Plan

 Exhibit 10.86 
  
 PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. 
 EMPLOYEE STOCK PURCHASE PLAN 
  
 THIS INSTRUMENT is executed as of the 1st day of March, 2005 by PHARMACEUTICAL PRODUCT DEVELOPMENT, INC., a
North Carolina corporation (the “Company”). 
  
 Statement of Purpose 
  
 The Company sponsors the
Pharmaceutical Product Development, Inc. Employee Stock Purchase Plan (the “Plan”) in order to provide eligible employees with the opportunity to purchase shares of the common stock of the Company and to thereby share in the continued
growth and success of the Company. The Company is hereby amending and restating the Plan effective with the Offering Period under the Plan commencing July 1, 2005 to (i) incorporate the provisions of prior amendments into a single document, (ii)
change the method for determining the purchase price of shares under the Plan to cause the Plan to be treated as a noncompensatory plan under the Financial Accounting Standards Board Statement No. 123(R) Share-Based Payment, as revised in 2004, and
(iii) otherwise meet current needs. 
  
 NOW, THEREFORE, for the
purposes aforesaid, the Company hereby amends and restates the Plan effective with the Offering Period under the Plan commencing July 1, 2005 to consist of the following Articles I through VIII: 
  
 ARTICLE I 
  
 NAME, PURPOSE, CONSTRUCTION AND DEFINITIONS 
  
 Section 1.1. Name. The Plan shall be known as the “Pharmaceutical Product Development, Inc. Employee Stock
Purchase Plan.” 
  
 Section 1.2. Purpose. The purpose
of the Plan is to provide Participants in the Plan with an opportunity to purchase Common Stock in the Company through payroll deductions and other contributions, thereby encouraging Participants to share in the economic growth and success of the
Company through stock ownership. 
  
 Section 1.3.
Construction. Article, Section and paragraph headings have been inserted in the Plan for convenience of reference only and are to be ignored in any construction of the provisions hereof. If any provision of the Plan shall be invalid or
unenforceable the remaining 

 
provisions shall nevertheless be valid, enforceable and fully effective. It is the intent that the Plan shall at all times constitute an “employee stock
purchase plan” within the meaning of Section 423(b) of the Code, and the Plan shall be construed and interpreted to remain such. The Plan shall be construed, administered, regulated and governed by the laws of the United States to the extent
applicable, and to the extent such laws are not applicable, by the laws of the State of North Carolina. 
  
 Section 1.4. Definitions. Whenever used in the Plan, unless the context clearly indicates otherwise, the following terms shall have the following
meanings: 
  
 (a) Beneficiary, with
respect to a Participant, means such Participant’s “Beneficiary” under the group term life insurance plan maintained by the Company. 
  
 (b) Board or Board of Directors means the Board of Directors of the Company or any Committee or Committees of said Board of
Directors of the Company to which, and to the extent, said Board of Directors of the Company has delegated some or all of its power, authority, duties or responsibilities with respect to the Plan. 
  
 (c) Code means the Internal Revenue Code of 1986, as
the same may be amended from time to time, and references thereto shall include the valid Treasury regulations issued thereunder. 
  
 (d) Committee means the “Committee” as defined under the Retirement Savings Plan which is responsible for the
administration of the Plan in accordance with Article VI hereof. 
  
 (e) Common Stock means shares of the $0.10 par value common stock of the Company and any other stock or securities resulting from the adjustment thereof or substitution therefor as described in Section 3.4.

  
 (f) Company means Pharmaceutical
Product Development, Inc., a North Carolina corporation. 
  
 (g) Compensation means “Contribution Compensation” as defined under the Retirement Savings Plan, except that Compensation under the Plan shall not be limited by Section 401(a)(17) of the Code.

  
 (h) Effective Date means July 1, 1997.

  
 (i) Employee means a person employed
by the Company. In addition, the employees of the Company’s subsidiaries which the Company designates in its sole and exclusive discretion as participating subsidiaries for purposes of this Plan shall also be considered Employees for purposes
of this Plan. 
  

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 (j) Fair Market Value, with respect to a share of Common Stock from time to time,
means (i) if the Common Stock is traded on the National Market System, the closing price of the Common Stock for the applicable date, as published in the NASDAQ National Market Issues report in the Eastern Edition of The Wall
Street Journal, (ii) if the Common Stock is not traded on the National Market System but such Common Stock is listed on a national securities exchange, the mean between the highest price and the lowest price at which the Common Stock
shall have been sold regular way on a national securities exchange on the applicable date during an Offering Period or, if there are no sales on said date, then on the next preceding date on which there were sales of Common Stock, (iii) if the
Common Stock is not traded on the National Market System or listed on a national securities exchange, the mean between the bid and asked prices last reported by the National Association of Securities Dealers, Inc. for the over-the-counter market on
the applicable date during an Offering Period or, if no bid and asked prices are reported on said date, then on the next preceding date on which there were such quotations, or (iv) if the Common Stock is not traded on the National Market System or
listed on a national securities exchange and quotations for the Common Stock are not reported by the National Association of Securities Dealers, Inc., the fair market value determined by the Committee on the basis of available prices for the Common
Stock or in such manner as the Committee shall agree. 
  
 (k) Offering means the offering of shares of Common Stock to Participants pursuant to this Plan that occurs on each Offering Date. 
  
 (l) Offering Date means July 1, 1997 and each succeeding January 1 and July 1. 
  
 (m) Offering Period means the period from an Offering
Date through the immediately succeeding Offering Date. 
  
 (n) Participant means an Employee who has become a Participant pursuant to Section 2.2 of the Plan. 
  
 (o) Plan means the Pharmaceutical Product Development, Inc. Employee Stock Purchase Plan, as set forth herein, together with any
and all amendments thereto. 
  

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 (p) Retirement Savings Plan means The Pharmaceutical Product Development, Inc.
Retirement Savings Plan as in effect from time to time. 
  
 (q) Stock Purchase Account, with respect to a Participant, means the account established on the books and records of the Company for such Participant representing the payroll deductions credited to such account
in accordance with the provisions of the Plan. 
  
 ARTICLE
II 
  
 PARTICIPATION 
  
 Section 2.1. General. No person shall become a Participant unless or
until such person is or becomes an Employee and upon or following satisfaction of the eligibility requirement set forth in the Plan. In addition, in no event shall any person be eligible to participate in the Plan before the Effective Date.

  
 Section 2.2. Participation Requirements. 
  
 (a) Eligibility Requirement. An Employee shall satisfy the
eligibility requirement for the Plan on the date the Employee is first employed by the Company, subject to the provisions of Section 2.2(c) below. 
  
 (b) Commencement of Participation. Each person who satisfies the eligibility requirement of Section 2.2(a) on or before the Effective Date shall
become a Participant in the Plan: 
  
 (1) on the
Offering Date coinciding with the Effective Date, if such person is an Employee on such Offering Date; or 
  
 (2) if such person is not an Employee on such Offering Date, then on the first Offering Date coinciding with or next following the date
(if any) on which such person again becomes an Employee after the Effective Date. 
  
 Each person who satisfies the eligibility requirement of Section 2.2(a) after the Effective Date shall become a Participant in the Plan: 
  
 (1) on the first Offering Date after such person satisfies the eligibility requirement, if such person is an Employee on such Offering
Date; or 
  
 (2) if such person is not an
Employee on such Offering Date, then on the first Offering Date coinciding with or next following the date (if any) on which such person again becomes an Employee. 
  

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 (c) Exclusions. Notwithstanding any provision of the Plan to the contrary, in no event shall the
following persons be eligible to participate in the Plan: 
  
 (1) Any Employee whose customary employment with the Company is twenty (20) hours or less per week; or 
  
 (2) Any Employee whose customary employment with the Company is for not more than five (5) months in any calendar year. 
  
 Section 2.3. Eligibility of Former Participants. If a person
terminates employment with the Company after becoming a Participant and subsequently resumes employment with the Company, such person shall again become a Participant on the Offering Date coinciding with or next following such resumption of
employment with the Company without having to satisfy again the eligibility requirement of Section 2.2(a). 
  
 ARTICLE III 
  
 OFFERING OF COMMON STOCK 
  
 Section 3.1.
Reservation of Common Stock. The Board of Directors has reserved one million two-hundred fifty thousand (1,250,000) shares of Common Stock for the Plan, subject to adjustment in accordance with Section 3.4. The aggregate number of shares of
Common Stock which may be purchased under the Plan by Participants shall not exceed one million two-hundred fifty thousand (1,250,000) shares, subject to adjustment in accordance with Section 3.4. 
  
 Section 3.2. Offering of Common Stock. 
  
 (a) General. Subject to Section 3.2(b), each Participant in the Plan
on an Offering Date shall be entitled to purchase shares of Common Stock on the last day of the Offering Period beginning with such Offering Date with the amounts deducted from such Participant’s Compensation or otherwise contributed during
such Offering Period pursuant to Article IV. The purchase price for such shares of Common Stock shall be determined under Section 3.3. 
  
 (b) Limitations. Notwithstanding Section 3.2(a), the maximum number of shares of Common Stock a Participant may purchase pursuant to an Offering
under Section 3.2(a) shall be subject to the following limitations: 
  
 (1) If as of the Offering Date for such Offering such Participant owns (including stock which such Participant is considered to own under Section 425(d) of the Code) stock (including the Common Stock such Participant
would be entitled to purchase pursuant to an Offering) possessing five percent (5%) or more of the total combined voting power or value of all classes of stock of the Company, then the maximum number of shares of Common Stock such Participant may
purchase pursuant to such Offering 

  

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shall be reduced so that the number of shares of Common Stock such Participant may purchase pursuant to such Offering when added to the number of shares of
stock of the Company such Participant owns (including stock which such Participant is considered to own under Section 425(d) of the Code) (excluding the Common Stock such Participant would be entitled to purchase pursuant to such Offering) is less
than five percent (5%) of the total combined voting power or value of all classes of stock of the Company; and 
  
 (2) If such Participant could acquire within the same calendar year as an Offering shares of stock of the Company under all “employee
stock ownership plans” within the meaning of Section 423(b) of the Code sponsored by the Company (including the Common Stock such Participant would be entitled to purchase pursuant to such Offering) having a total fair market value (determined
as of the date of such Offering) which exceeds Twenty-Five Thousand Dollars ($25,000), then the maximum number of shares such Participant may purchase pursuant to such Offering shall be reduced so that such total fair market value does not exceed
Twenty-Five Thousand Dollars ($25,000). 
  
 (3)
In no event may the total number of shares of Common Stock that may be purchased by Participants for any Offering Period exceed the lesser of (A) an amount that the Board of Directors may, in its sole and exclusive discretion, establish from time to
time or (B) the total remaining shares available pursuant to Section 3.1. In the event that the total number of shares of Common Stock to be purchased for an Offering Period would otherwise exceed the limit set forth in the preceding sentence, the
Committee shall first reduce shares to be purchased by non-payroll deduction additional cash contributions for such Offering Period proportionately among all Participants who have made such additional cash contributions; and if such limit would
still be exceeded, the Committee shall then reduce shares to be purchased by payroll deductions for such Offering Period proportionately among all Participants who have made such payroll deductions. 
  
 Section 3.3. Determination of Purchase Price for Offered Common Stock.
The purchase price per share of the shares of Common Stock offered to Participants pursuant to an Offering shall be equal to ninety-five percent (95%) of the Fair Market Value of a share of Common Stock as of the last day of the Offering Period for
such Offering; provided, however, that in no event shall the purchase price be less than the par value of a share of Common Stock. 
  
 Section 3.4. Effect of Certain Transactions. The number of shares of Common Stock reserved for the Plan pursuant to Section 3.1 and the
determination under Section 3.3 of the purchase price per share of the shares of Common Stock offered to Participants pursuant to an Offering shall be appropriately adjusted to reflect any increase or decrease in the number of issued shares of
Common Stock resulting from a stock split, a consolidation of shares, the payment of a stock dividend or any other capital adjustment affecting the number of issued shares of Common Stock. In the event that the outstanding shares of Common Stock
shall be 

  

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changed into or exchanged for a different number or kind of shares of stock or other securities of the Company or another corporation, whether through
reorganization, recapitalization, merger, consolidation or otherwise, then there shall be substituted for each share of Common Stock reserved for issuance under the Plan but not yet purchased by Participants, the number and kind of shares of stock
or other securities into which each outstanding share of Common Stock shall be so changed or for which each such share shall be exchanged. 
  
 ARTICLE IV 
  
 PAYROLL DEDUCTIONS 
  
 Section 4.1. Payroll Deduction Elections. A Participant in the Plan (or a person who will become a Participant in the Plan on the next Offering Date if such person is an Employee on such Offering Date) who
wishes to purchase shares of Common Stock to be offered to such Participant on the next Offering Date shall elect to have the Company deduct from the Compensation payable to such Participant during the Offering Period beginning on such Offering Date
any amount between one percent (1%) and fifteen percent (15%) of such Participant’s Compensation, in whole multiples of one percent (1%). Such election shall be made by delivering to the Committee during the forty-five (45) day period preceding
such Offering Date a written direction to make such deductions. Such election shall become effective as of the first day of such Participant’s first pay period that begins on or after such Offering Date and shall remain effective for each
successive pay period until changed or terminated pursuant to this Article IV. In addition, at any time during an Offering Period, a Participant may make additional contributions from the Participant’s own funds towards the purchase of Common
Stock under the Plan for such Offering Period. Such additional contributions must be made in cash or its equivalent under procedures established from time to time by the Committee. Notwithstanding the foregoing, (i) for the Offering Period beginning
on January 1, 1998, the maximum amount of such additional contributions that may be made by any Participant shall not exceed five thousand dollars ($5,000) and (ii) no such additional contributions shall be permitted for Offering Periods beginning
on or after July 1, 1998. 
  
 Section 4.2. Election to Increase
or Decrease Payroll Deductions. Subject to Section 4.5, a Participant who has a payroll deduction election in effect under Section 4.1 may prospectively increase or decrease during an Offering Period the percentage amount of the deductions being
made by the Company from such Participant’s 

  

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Compensation (including a decrease to zero (0)) by delivering to the Committee a written direction to make such change. Such change shall become effective as
soon as practical after the Committee’s receipt of such written direction and shall remain in effect until changed or terminated pursuant to this Article IV. 
  
 Section 4.3. Termination of Election Upon Termination of Employment. The termination of employment of a
Participant with the Company for any reason shall automatically terminate the election (if any) of such Participant to have amounts deducted from such Participant’s Compensation pursuant to this Article IV that is then in effect. Such
termination shall be effective immediately following the pay period during which such termination of employment occurs, but shall not affect the deduction from Compensation for that pay period. 
  
 Section 4.4. Change or Termination Not Retroactively Effective.
Neither the change nor the termination of any election to have amounts deducted from Compensation under this Article IV shall increase, decrease or otherwise affect the deduction from the Compensation of a Participant for any pay period ending prior
to the effective date of such change or termination. 
  
 Section
4.5. Form, Timing and Frequency of Elections. Any written direction by any Participant with respect to any deductions from Compensation pursuant to this Article IV shall be on a form furnished by the Committee for such purpose and shall be
made by such Participant’s completing, signing and filing such form with the Committee in the manner prescribed from time to time by the Committee. A Participant shall be permitted to increase or decrease the percentage amount of the deductions
being made by the Company from such Participant’s Compensation only once during an Offering Period; provided, however, a Participant may terminate the deductions being made by the Company from such Participant’s Compensation
at any time during an Offering Period notwithstanding any prior change in the amount of such Participant’s Compensation deductions during such Offering Period. 
  
 ARTICLE V 
  
 STOCK PURCHASE ACCOUNTS AND PURCHASE OF COMMON STOCK 
  
 Section 5.1. Stock Purchase Accounts. A Stock Purchase Account shall be established and maintained on the books and records of the Company for each
Participant. Amounts deducted from a Participant’s Compensation or otherwise contributed by the Participant pursuant to Article IV shall be credited to such Participant’s Stock Purchase Account. No interest or other increment shall accrue
or be payable to any Participant with respect to any amounts credited to 

  

 8 

 
such Stock Purchase Accounts. All amounts credited to such Stock Purchase Accounts shall be withdrawn, paid or applied toward the purchase of Common Stock
pursuant to the provisions of this Article V. 
  
 Section 5.2.
Purchase of Common Stock. 
  
 (a) General. As of
the last day of each Offering Period, the amount to the credit of a Participant in such Participant’s Stock Purchase Account shall be used to purchase from the Company on such Participant’s behalf the largest number of whole and fractional
shares of Common Stock which can be purchased at the price determined under Section 3.3 with the amount then credited to such Participant’s Stock Purchase Account subject to the limitations set forth in Article III on the maximum number of
shares of Common Stock such Participant may purchase. As of such date, such Participant’s Stock Purchase Account shall be charged with the aggregate purchase price of the shares of Common Stock purchased on such Participant’s behalf.

  
 (b) Issuance of Common Stock. The shares of Common
Stock purchased for a Participant on the last day of an Offering Period shall be deemed to have been issued by the Company for all purposes as of the close of business on such date. Prior to such date, none of the rights and privileges of a
shareholder of the Company shall exist with respect to such shares of Common Stock. As soon as practicable after such date, the Company shall issue and deliver, or shall cause its stock transfer agent to issue and deliver, a certificate for the
number of shares of Common Stock purchased for a Participant on such date, which such certificate shall be issued in the Participant’s name. 
  
 (c) Insufficient Common Stock Available. If as of the last day of any Offering Period, the aggregate Stock Purchase Accounts available for the
purchase of shares of Common Stock pursuant to Section 5.2(a) would purchase a number of shares of Common Stock in excess of the number of shares of Common Stock then available for purchase under the Plan, (i) the number of shares of Common Stock
which would otherwise be purchased for each Participant on such date shall be reduced proportionately to the extent necessary to eliminate such excess, (ii) the remaining balance to the credit of each Participant in each such Participant’s
Stock Purchase Account shall be distributed to each such Participant and (iii) the Plan shall terminate automatically upon the distribution of the remaining balance in such Stock Purchase Accounts. 
  
 Section 5.3. Withdrawal From Plan Prior to Purchase of Common
Stock. In the event (i) a Participant terminates employment with the Company for any reason during an Offering 

  

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Period, or (ii) a Participant terminates deductions from such Participant’s Compensation pursuant to Article IV during an Offering Period and such
Participant elects to withdraw in writing from the Plan, then the entire amount to the credit of such Participant in such Participant’s Stock Purchase Account shall be distributed to such Participant (or if such Participant is deceased, to such
Participant’s Beneficiary) as soon as administratively practicable after such termination of employment or withdrawal (as the case may be). If a Participant terminates deductions from such Participant’s Compensation pursuant to Article IV
during an Offering Period but such Participant does not elect to withdraw in writing from the Plan, the amount to the credit of such Participant in such Participant’s Stock Purchase Account shall be used to purchase shares of Common Stock for
such Participant as of the last day of such Offering Period to the extent provided in Section 5.2(a) and the remaining balance in such Participant’s Stock Purchase Account shall be distributed to such Participant as soon as administratively
practicable. Notwithstanding the preceding sentence, if a Participant terminates deductions from such Participant’s Compensation pursuant to Article IV during an Offering Period and the amount to the credit of such Participant in such
Participant’s Stock Purchase Account upon such termination of Compensation deductions does not exceed One Hundred Dollars ($100.00), then such Participant shall be deemed to have withdrawn from the Plan upon such termination of Compensation
deductions for purposes of this Section 5.3. 
  
 ARTICLE VI

  
 COMMITTEE 
  
 Section 6.1. Organization of Committee. The Committee for purposes of
the Plan shall be the “Committee” as defined under the Retirement Savings Plan. The Committee may appoint such agents, who need not be members of the Committee, as it may deem necessary for the effective performance of its duties, and may
delegate to such agents such powers and duties, whether administerial or discretionary, as the Committee may deem expedient or appropriate. The Committee shall act by majority vote and may adopt such bylaws, rules and regulations as it deems
desirable for the conduct of its affairs. 
  
 Section 6.2.
Powers of Committee. The Committee shall administer the Plan. The Committee shall have all powers necessary to enable it to carry out its duties under the Plan properly. Not in limitation of the foregoing, the Committee shall have the power
to construe and interpret the Plan and to determine all questions that shall arise thereunder. It shall decide all 

  

 10 

 
questions relating to eligibility to participate in the Plan and to purchase Common Stock under the Plan. The Committee shall have such other and further
specified duties, powers, authority and discretion as are elsewhere in the Plan either expressly or by necessary implication conferred upon it. The decision of the Committee upon all matters within the scope of its authority shall be final and
conclusive on all persons, except to the extent otherwise provided by law. 
  
 Section 6.3. Expenses of Committee. The reasonable expenses of the Committee incurred by the Committee in the performance of its duties under the Plan, including without limitation reasonable counsel fees and
the expenses of other agents, shall be paid by the Company. 
  
 Section 6.4. Indemnification of Committee. To the extent permitted by applicable law, the Company shall indemnify and hold harmless each member of the Committee from and against any and all liability, claims, demands, costs and
expenses (including the costs and expenses of attorneys incurred in connection with the investigation or defense of claims) in any manner connected with or arising out of any actions or inactions in connection with the administration of the Plan
except for such actions or inactions which are not in good faith or which constitute willful misconduct. 
  
 ARTICLE VII 
  
 AMENDMENT AND TERMINATION 
  
 Section 7.1.
Amendment of Plan. The Company expressly reserve the right, at any time and from time to time, to amend in whole or in part any of the terms and provisions of the Plan for whatever reason(s) the Company may deem appropriate. The Company shall
require shareholder approval of any such amendment to the extent the Company determines that shareholder approval is required by applicable law. 
  
 Section 7.2. Termination of Plan. The Company expressly reserves the right, at any time and for whatever reason it deems appropriate, to terminate
the Plan. Upon any termination of the Plan, the entire amount credited to the Stock Purchase Account of each Participant shall be distributed to each such Participant. 
  
 Section 7.3. Effective Date and Procedure for Amendment or Termination. Any amendment to the Plan or termination of
the Plan may be retroactive to the extent not prohibited by applicable law. Any amendment to the Plan or termination of the Plan shall be made by the Company by resolution of the Board of Directors and shall not require the approval or consent of
any Participant or Beneficiary in order to be effective. 
  

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 ARTICLE VIII 
  
 MISCELLANEOUS 
  
 Section 8.1. Transferability of Rights. To the extent permitted by law, rights to purchase shares of Common Stock are exercisable only by the
Participant to whom such rights are granted and are not transferable by such Participant other than by will or the laws of descent and distribution. 
  
 Section 8.2. No Employment Rights. Participation in the Plan shall not give any employee of the Company any right to remain in the employ of the
Company or upon termination of employment, any right or interest in the Plan except as expressly provided herein. 
  
 Section 8.3. Compliance with Law. No shares of Common Stock shall be issued under the Plan prior to compliance by the Company to the satisfaction
of its counsel with any applicable laws. 
  
 Section 8.4.
Repurchase of Common Stock. The Company shall not be required to repurchase from any Participant any shares of Common Stock which such Participant acquires under this Plan. 
  
 IN WITNESS WHEREOF, the Company have caused this Instrument to be executed by its duly authorized officer as of the day and
year first above written. 
  
  

			
	 PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.

		
	By:	 	 /s/ Fred N. Eshelman

	Name:	 	Fred N. Eshelman
	Title:	 	Chief Executive Officer

  

 12Severance Agreement

 Exhibit 10.162 
  

					
	 Employee

	 	 Section 2.01 Base Salary
 and Bonus Multiplier

	 	 Section 2.03 Welfare
 Benefit Period

	 Fredric N. Eshelman
	 	3.0	 	2 years
	 Fred B. Davenport, Jr.
	 	2.5	 	2 years
	 Linda Baddour
	 	2.5	 	2 years
	 Paul S. Covington
	 	2.5	 	1 year
	 Colin Shannon
	 	2.0	 	1 year
	 Brainard Judd Hartman
	 	1.0	 	1 year
	 Kim V. Greene
	 	1.0	 	1 year
	 Edward J. Murray
	 	1.0	 	1 year

 SEVERANCE AGREEMENT 
  
 THIS AGREEMENT, effective the 1st day of January, 2001, by and between Pharmaceutical Product Development, Inc. and its
subsidiaries and affiliates (collectively, “PPD”) and                      (“Employee”). 
  
 WHEREAS, Employee is a valued employee of PPD and in order to induce Employee
to remain in the employ of PPD, PPD desires to provide the severance benefits hereinafter described in the event of a “Change in Control”, as hereinafter defined, of PPD. 
  
 NOW, THEREFORE, it is agreed as follows: 
  
 1. Definitions 
  
 1.01 “AFR” means the interest rate determined under Section 1274 of the Code. 
  
 1.02 “Base Amount” shall have the meaning set forth and
shall be determined as provided in Section 280G of the Code. 
  
 1.03 “Change in Control” means (i) a change of control of a nature that would be required to be reported in response to Item 6(e) of Schedule 14A of Regulation 14A promulgated under the Securities Exchange Act of
1934, as amended (“Exchange Act”), provided that such a Change in Control shall be deemed to have occurred if any “person” (as such term is used in Sections 13(d) and 14(d)(2) of the Exchange Act) is or becomes the beneficial
owner, directly or indirectly, of securities of PPD representing 50% or more of the combined voting power of PPD’s then outstanding securities; (ii) a sale of substantially all of the assets of PPD; or (iii) a liquidation of PPD. 
  
 1.04 “Constructive Termination” means a termination of
Employee’s employment by PPD during the Covered Period initiated by Employee after (i) a substantial diminution or alteration in the duties of Employee, (ii) a reduction by PPD in Employee’s base salary in effect on the date of the Change
in Control, or (iii) the relocation of Employee’s primary work location to a location that is more than twenty-five (25) miles from Employee’s primary work location prior to the Change in Control. Constructive Termination specifically does
not include termination of Employee by reason of death, Disability or retirement at or after age 65. Employee shall give PPD written notice of a Constructive Termination, which notice shall provide a brief description of the circumstances which
Employee asserts gives rise to a right of Constructive Termination, and PPD shall have ten (10) days from receipt of said notice within which to remedy said circumstances. 
  

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 1.05 “Covered Payment” means the amounts and benefits paid to Employee pursuant to this
Agreement, taken together with any amounts or benefits otherwise paid or distributed to Employee by PPD. 
  
 1.06 “Covered Period” means the time period commencing on the date of and coincident with a Change of Control and ending one year
thereafter. 
  
 1.07 “Disability” means
the inability of Employee to perform his assigned duties for PPD for a period of three (3) months due to Employee’s physical or mental illness as determined by a reputable medical doctor. 
  
 1.08 “Excess Parachute Payment” shall have the meaning set
forth and shall be determined as provided in Section 280G of the Code. 
  
 1.09 “Excise Tax” shall mean the tax imposed under Section 4999 of the Code on an Excess Parachute Payment. 
  
 1.10 “Executive Consultant” shall mean the executive compensation or comparable consultant used from time to time by PPD in designing its
compensation program for executive and senior management employees of PPD; provided, however, that in its sole discretion PPD may at any time designate its independent auditors as its Executive Consultant for the purpose of performing any
calculations required under Section 2.05 of this Agreement. 
  
 1.11 “Final Determination” means a final determination by a court of competent jurisdiction or a proceeding of the Internal Revenue Service or its successor agency. 
  
 1.12 “First Period” means the twelve-month period ending on
the Termination Date. 
  
 1.13 “Internal Revenue
Code” means the Internal Revenue Code of 1986 as heretofore or hereafter amended, and any successor code. References in this agreement to specific sections of the Code shall also include any successor sections. 
  
 1.14 “Parachute Payments” shall have the meaning set forth
and shall be determined as provided in Section 280G of the Code. 
  
 1.15 “Payment Cap” means the maximum amount which may be paid to Employee under the terms of this Agreement without subjecting Employee to the Excise Tax. 
  
 1.16 “Payment Date” means the date thirty (30) days following the Termination Date. 
  

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 1.17 “Stock Awards” means Employee’s outstanding awards of PPD non-qualified stock
options or restricted stock as of the Termination Date. 
  
 1.18 “Termination for Cause” means (i) an act or acts involving fraud, embezzlement or theft from PPD, (ii) Employee’s willful and repeated failure to follow directions of the Board of Directors that continues for at
least ten (10) days following written notice of the Board of Directors of such failure to follow directions, or (iii) termination for cause as defined in and made pursuant to a then effective employment agreement, if any, between Employee and PPD.

  
 1.19 “Termination Date” means the date on
which Employee’s employment is terminated such that Employee is entitled to the compensation and benefits provided for in Section 2 of this Agreement. 
  
 2. Compensation Upon Change of Control. If during the Covered Period (i) PPD terminates Employee’s employment for reason other than
Termination for Cause or (ii) Employee’s employment is terminated by reason of Constructive Termination, Employee shall be entitled to the following compensation and benefits: 
  
 2.01 Base Salary and Bonus. PPD shall pay Employee an amount equal to
                     times the sum of Employee’s (i) base salary for the First Period (determined as if Employee was employed for the
entire First Period if employed for less than the First Period) and (ii) the greater of (x) Employee’s target bonus under the PPD incentive cash bonus plan in which Employee is eligible to participate immediately prior to the Termination Date
or (y) the average of the cash bonuses received in the First Period and in the twelve-month period immediately preceding the First Period, said amount to be paid on the Payment Date. 
  
 2.02 Unpaid and Deferred Compensation. PPD shall pay Employee any bonus or deferred compensation (whether in the form
of cash, stock or otherwise) accrued but unpaid as of the Termination Date, said sum to be paid on the Payment Date. 
  
 2.03 Benefits. For a period of
                     after the Termination Date, PPD shall continue to pay for and provide welfare benefits which Employee was receiving
immediately prior to the Termination Date, including life insurance, health, medical, dental, vision and wellness, accidental death and dismemberment and disability benefits; provided, however, that PPD’s obligations under this clause shall
terminate from the date that Employee first becomes eligible after the Termination Date for similar coverage under another employer’s plan. 
  
 2.04 Stock Awards. Notwithstanding anything to the contrary in any agreement for Stock Awards, (i) all unvested shares underlying Stock Awards
granted more than six months prior to the Termination Date shall become fully vested as of the Termination Date, and (ii) Employee shall continue to be treated under each award agreement evidencing a Stock Award as if Employee was an employee of PPD
until the 

  

 4 

 
first to occur of (x) the third anniversary of the Termination Date, or (y) the expiration of the exercise period provided for therein; provided, however, in
the event of Employee’s death or his disability (as disability is defined in the award agreement) after the Termination Date, the time for exercise after death or such disability prescribed in the award agreement shall apply. The provisions of
this Section 2.04 shall also apply to any and all substitute awards for nonqualified stock options and restricted stock granted to Employee in exchange for Stock Awards to which this section applies. 
  
 2.05 Limitation on Payments. 
  
 a. Application of Section 2.05. If a Covered Payment hereunder would
be an Excess Parachute Payment and would thereby subject Employee to the Excise Tax, the provisions of this Section 2.05 shall apply to determine the amounts payable to Employee pursuant to this Agreement. 
  
 b. Calculation of Benefits. At least fifteen (15) days prior to the
Payment Date, PPD shall notify Employee of the aggregate present value of all amounts and benefits to which Employee would be entitled under this Agreement and any other plan, program or arrangement with PPD as of the Termination Date, together with
the projected maximum payments, determined as of such Date of Termination, that could be paid without Employee being subject to the Excise Tax. 
  
 c. Imposition of Payment Cap. If (i) the aggregate value of all amounts and benefits to which Employee would be entitled under this Agreement and
any other plan, program or arrangement with PPD exceeds the amount which can be paid to Employee without Employee incurring an Excise Tax and (ii) Employee would receive a greater net after-tax amount (taking into account all applicable taxes
payable by Employee, including an Excise Tax) by applying the limitation contained in this Section 2.05(c), then the amounts otherwise payable to Employee under this Section 2 shall be reduced to an amount equal to the Payment Cap. If Employee
receives reduced payments and benefits hereunder, Employee shall have the right to designate which of the payments and benefits otherwise provided for in this Agreement that Employee will receive in connection with the application of the Payment
Cap. 
  
 d. Application of Code Section 280G. The
Executive Consultant shall determine whether any part of the Covered Payment will be subject to the Excise Tax and the amount of such Excise Tax. For purposes of such determination, the Executive Consultant shall take into consideration and be
guided by the following: 
  
 (i) such Covered Payment
will be treated as Parachute Payments and all Parachute Payments in excess of the Base Amount shall be treated as subject to the Excise Tax, unless and except to the extent that in the good faith judgment of the Executive Consultant, PPD has a
reasonable basis to conclude that such Covered Payment, in whole or in part, either do not constitute Parachute Payments or represent reasonable compensation for personal services actually rendered (within the meaning of Section 280G of the Code) in
excess of the Base Amount, or such Parachute Payments are otherwise not subject to the Excise Tax, and 
  

 5 

 (ii) the value of any noncash benefits or any deferred payment or benefit shall be determined by
the Executive Consultant in accordance with the principles of Section 280G of the Code. 
  
 (e) Applicable Tax Rates. For purposes of determining whether Employee would receive a greater net after-tax benefit if the amounts payable under this Agreement are reduced in accordance with Section 2.05(c),
Employee shall be deemed to pay: 
  
 (i) federal income
taxes at the highest applicable marginal rate of federal income taxation for the calendar year in which the first amounts are to be paid hereunder, and  
  

(ii) any applicable state and local income taxes at the highest applicable marginal rate of taxation for such calendar year, net of the maximum
reduction in federal income taxes which could be obtained from the deduction of such state or local taxes if paid in such year; 
  
 provided, however, that Employee may request that such determination be made based on Employee’s individual tax circumstances, which shall govern such determination
so long as Employee provides to the Executive Consultant such information and documents as the Executive Consultant shall reasonably request to determine such individual circumstances. 
  
 (f) Adjustments in Respect to Payment Cap. 
  
 (i) If Employee receives reduced payments and benefits under Section 2.05 or if Section 2.05 is determined not to be
applicable to Employee because the Executive Consultant concludes that Employee is not subject to any Excise Tax, and it is established pursuant to a Final Determination that, notwithstanding the good faith of Employee and PPD in applying the terms
of this Agreement, the aggregate Parachute Payments paid to Employee or for Employee’s benefit are in an amount that would result in Employee being subject to an Excise Tax and Employee would still be subject to the Payment Cap under the
provisions of Section 2.05(c), then the amount in excess of the Payment Cap shall be deemed for all purposes to be a loan to Employee made on the date of the receipt of such excess payment, which Employee shall have an obligation to repay to PPD on
demand, together with interest at the AFR, from the date of the payment hereunder to the date of repayment by Employee. 
  
 (ii) If Section 2.05 is not applied to reduce Employee’s entitlements under this Section 2 because the Executive Consultant determines that
Employee would not receive a greater net after-tax benefit by applying Section 2.05 and it 

  

 6 

 
is established pursuant to a Final Determination that, notwithstanding the good faith of Employee and PPD in applying the terms of this Agreement, Employee
would have received a greater net after-tax benefit by subjecting Employee’s payments and benefits hereunder to the Payment Cap, then the aggregate Parachute Payments paid to Employee or for Employee’s benefit in excess of the Payment Cap
shall be deemed for all purposes a loan to Employee made on the date of receipt of such excess payments, which Employee shall have an obligation to repay to PPD on demand, together with interest at the AFR, from the date of payment hereunder to the
date of repayment by Employee. 
  
 (iii) If Employee
receives reduced payments and benefits by reason of this Section 2.05 and it is established pursuant to a Final Determination that Employee could have received a greater amount without exceeding the Payment Cap, then PPD shall promptly thereafter
pay Employee the aggregate additional amount which could have been paid without exceeding the Payment Cap, together with interest on such amount at the AFR, from the original payment due date to the date of actual payment by PPD. 
  
 3. Miscellaneous. 
  
 3.01 Successor-in-Interest. PPD will require any successor (whether
direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially all of the business and/or assets of PPD, to expressly assume and agree to perform this Agreement in the same manner and to the same extent that PPD would
be required to perform it if no succession had taken place. 
  
 3.02 Binding Effect. This Agreement shall inure to the benefit of and be enforceable by Employee’s personal or legal representatives, executives, administrators, successors, heirs, distributees, devisees and legatees.

  
 3.03 Notice. For purposes of this Agreement, notices
and all other communications provided for in the Agreement shall be in writing and shall be given (i) by certified mail, return receipt requested, postage prepaid, (ii) by personal delivery or (iii) by recognized overnight carrier, and shall be
deemed received when actually received. Notices shall be addressed as follows: 
  

			
	If to PPD:	  	Pharmaceutical Product Development, Inc.
	 	  	3151 South 17th Street
	 	  	Wilmington, North Carolina 28412
	 	  	Attention: Chief Executive Officer
		
	If to Employee:	  	  

		
	 	  	

		
	 	  	

		
	 	  	

  

 7 

 Either party hereto may change the notice address by giving notice thereof in the manner provided for herein. 

 
 3.04 Waiver. No waiver by either party hereto at any time of any
breach by the other party hereto of, or compliance with, any provision or condition of this Agreement to be performed by such other party shall be deemed a subsequent waiver of the same or similar provisions or conditions. 
  
 3.05 Entire Agreement. No agreements or representations, oral or
otherwise, expressed or implied, with respect to the subject matter hereof have been made by either party which are not set forth expressly in this agreement, and this Agreement supersedes and replaces in its entirety all prior agreements and
representations, expressed, implied, oral or otherwise, made by PPD to or with Employee, including but not limited to that certain Severance Agreement dated
                     between PPD and Employee. 
  
 3.06 Governing Law. This Agreement shall be governed by and interpreted under the laws of the State of North Carolina. 
  
 3.07 Unenforceability. The invalidity or unenforceability of any
provision of this Agreement shall not affect the validity or enforceability of any other provision of this Agreement. 
  
 3.08 Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original but all of which together
shall constitute one and the same instrument. 
  
 3.09
Headings. Headings used in this Agreement are for convenience only and shall not be used to construe or interpret this Agreement. 
  
 3.10 Enforcement by Employee. All legal expenses incurred by Employee in the successful enforcement of any of the terms of this Agreement shall be
paid by PPD. 
  
 IN WITNESS WHEREOF, the parties have executed
this Agreement effective the date first hereinabove set forth. 
  

					
	Pharmaceutical Product Development, Inc.	 	Employee
			
	By:	 	  

	 	

	Name:	 	 	 	Name:
	Title:	 	 	 	 

  

 8

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