Document:

<PAGE>   1
                                                                    EXHIBIT 4.3

                              LETTER OF TRANSMITTAL
                               WITH RESPECT TO THE
                   CONVERSION AND EXCHANGE OF COMMON STOCK OF
                                 GEMINI IX, INC.
                           FOR SHARES OF COMMON STOCK
                                       OF
                        AMERICAN FINANCIAL HOLDING, INC.

Mail or deliver this Letter of Transmittal, or a facsimile hereof, together with
your certificate(s) of Gemini Common Stock (as defined below) to Fidelity
Transfer Company, the Exchange Agent. For information, contact Benchmark Equity
Group ("Benchmark"), 700 Gemini, Houston, Texas 77058, Attention: Jeffrey W.
Tomz at 281-488-3883. For information regarding your certificates for Company
Common Stock (as defined below) contact Fidelity Transfer Company at
1-800-484-7222.

<Table>
<Caption>
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                                        DESCRIPTION OF SURRENDERED CERTIFICATES
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<S>                                                                         <C>             <C>                  <C>
       NAME(s) AND ADDRESS(ES) OF REGISTERED HOLDER(S)                             SHARE CERTIFICATE(S) SURRENDERED
(PLEASE FILL IN, IF BLANK, AS NAME(S) APPEAR(S) ON SHARE CERTIFICATE(S))    (PLEASE ATTACH ADDITIONAL LIST, IF NECESSARY)
---------------------------------------------------------------------------------------------------------------------------

                                                                               SHARE        TOTAL NUMBER OF       NUMBER
                                                                            CERTIFICATE   SHARES REPRESENTED    OF SHARES
                                                                             NUMBER(S)     BY CERTIFICATE(S)   SURRENDERED*
---------------------------------------------------------------------------------------------------------------------------

                                                                          -------------------------------------------------

                                                                          -------------------------------------------------

                                                                          -------------------------------------------------

                                                                          -------------------------------------------------

                                                                          -------------------------------------------------

                                                                          -------------------------------------------------

                                                                          -------------------------------------------------

                                                                          -------------------------------------------------

---------------------------------------------------------------------------------------------------------------------------

                                                                                           TOTAL SHARES
---------------------------------------------------------------------------------------------------------------------------

* Unless otherwise indicated, all Shares represented by certificate(s) delivered to the Exchange Agent will be deemed to
  have been surrendered.
---------------------------------------------------------------------------------------------------------------------------
</Table>

         Please issue one (1) certificate to the undersigned shown above (unless
a different name is indicated in the Special Issuance Instructions box below)
representing the conversion and exchange of the shares of Gemini Common Stock,
for delivery by mail to the address shown above (unless a different address is
indicated in the Special Delivery Instructions box or the Special Issuance
Instructions box below).

<PAGE>   2

Ladies and Gentlemen:

         In connection with the merger (the "Merger") of ISO Acquisition Corp.,
a Delaware corporation ("Merger Sub"), and Gemini IX Inc., a Delaware
corporation ("Gemini"), with and into Isolagen Technologies, Inc., a Delaware
corporation ("Isolagen"), and pursuant to the Agreement and Plan of Merger,
dated August 1, 2001, by and among American Financial Holding, Inc., a Delaware
corporation and parent company of Merger Sub (the "Company"), Merger Sub,
Gemini, Isolagen and William K. Boss, Jr., Olga Marko and Dennis McGill (the
"Merger Agreement"), the undersigned, the registered holder(s) of the stock
certificate(s) (the "Certificate(s)") listed above, which formerly represented
shares of common stock, par value $0.0001 per share, of Gemini ("Gemini Common
Stock"), hereby surrenders such Certificate(s) in exchange for shares of common
stock, par value $0.001 per share, of the Company ("Company Common Stock"). The
undersigned understands that the Merger has been approved by the Boards of
Directors and stockholders of Merger Sub, Gemini and Isolagen and the Board of
Directors of the Company and agrees, in accordance with the terms and conditions
of the Merger Agreement, to accept 3,200 shares of Company Common Stock for each
share Gemini Common Stock surrendered. No fractional shares will be issued.
Fractional shares of 0.5 or greater will be rounded up and fractional shares of
less than 0.5 will be rounded down without cash payment. The shares of the
Company Common Stock received by the undersigned as a result of the exchange of
the Certificate(s) are characterized as "restricted securities" under the
federal securities laws inasmuch as they are being acquired from the Company in
a transaction not involving a public offering, and under such laws and
applicable regulations such shares may be resold without registration under the
Securities Act of 1933, as amended (the "Securities Act"), only in certain
limited circumstances. Undefined capitalized terms herein are defined in the
Merger Agreement.

         All authority herein conferred or agreed to be conferred shall survive
the death or incapacity of the undersigned, and any obligation of the
undersigned hereunder shall be binding upon the heirs, personal representatives,
estates, successors and assigns of the undersigned. The undersigned hereby
represents and warrants that the undersigned is the holder of the Certificate(s)
delivered hereby and has full power and authority to submit and exchange the
Certificate(s) surrendered and delivered for exchange hereby. The undersigned
will, upon request, execute and deliver any additional documents deemed by the
Exchange Agent or the Company to be necessary or desirable to complete the
exchange of the Certificate(s) tendered for exchange hereby.

         The undersigned hereby irrevocably constitutes and appoints the
Exchange Agent the true and lawful attorney-in-fact of the undersigned with
respect to the Certificate(s) with full power of substitution (such power of
attorney being deemed to be an irrevocable power coupled with an interest) to
cancel the Certificate(s) and deliver such Certificate(s) to Isolagen and to
deliver to the undersigned the shares of Company Common Stock to which the
undersigned is entitled upon the surrender of the Certificate(s).

         The undersigned understands and agrees that the method of delivery of
the Certificate(s) and this Letter of Transmittal is at the election and risk of
the holder of the Certificate(s). If delivery of the Certificate(s) is by mail,
registered mail with return receipt requested, properly insured, is recommended.

         The undersigned hereby acknowledges that the undersigned has read the
Instructions accompanying this Letter of Transmittal.

<PAGE>   3
<Table>
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<S>                                     <C>
                          SPECIAL ISSUANCE INSTRUCTIONS
                          (See Instructions 2, 4 and 6)

(To be completed only if the certificates for shares of Company Common Stock are
to be issued in the name of someone other than the undersigned.)

Issue and mail shares of Company Common Stock to:

Name:
     --------------------------------------------------------------------------
                                 (Please Print)

Address:
        -----------------------------------------------------------------------

-------------------------------------------------------------------------------
(City)                             (State)                   (ZIP)

                         (COMPLETE SUBSTITUTE FORM W-9)

                   (Tax Identification or Social Security No.)
-------------------------------------------------------------------------------
</Table>

<Table>
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<S>                                          <C>
BY EXECUTING THIS LETTER OF TRANSMITTAL, THE UNDERSIGNED HEREBY DELIVERS TO THE
COMPANY FOR EXCHANGE THE CERTIFICATE(S) INDICATED IN THE BOX ENTITLED
"DESCRIPTION OF SURRENDERED CERTIFICATES."

                                   SIGN HERE:
                               (See Instruction 4)
                         (Complete Substitute Form W-9)

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------
                           (Signature(s) of Holder(s))

Dated:                                     , 2001
      ------------------------------------

Name:
     --------------------------------------------------------------------------
                                 (Please Print)

-------------------------------------------------------------------------------
            (Title of signer if acting in a representative capacity)

Address:
        -----------------------------------------------------------------------

-------------------------------------------------------------------------------
(City)                             (State)                       (ZIP)

Telephone Number
                ---------------------------------------------------------------

--------------------------------------------------------------------------------
</Table>

<Table>
--------------------------------------------------------------------------------
<S>                                <C>
                          SPECIAL DELIVERY INSTRUCTIONS
                          (See Instructions 2, 4 and 6)

(To be completed only if the certificates for shares of Company Common Stock are
to be mailed to the undersigned at an address other than that shown in the box
on the cover sheet.)

Mail shares of Company Common Stock to:

Name:
     --------------------------------------------------------------------------
                                 (Please Print)

Address:
        -----------------------------------------------------------------------

-------------------------------------------------------------------------------
(City)                                  (State)                    (ZIP)

-------------------------------------------------------------------------------
</Table>

<Table>
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<S>                                <C>
                          SIGNATURE(S) GUARANTEED BY:

                      (To be completed only if required by
                             Instructions 2 and 4)

The undersigned hereby guarantees the signature(s) which appear(s) on this
Letter of Transmittal and the Certificate(s) surrendered pursuant to this
Letter of Transmittal.

-------------------------------------------------------------------------------
                    (Name of Institution Issuing Guarantee)

By:
   ----------------------------------------------------------------------------
                             (Authorized Signature)

Title:
      -------------------------------------------------------------------------

Address of Guaranteeing Firm:
                             --------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

Dated:                                     , 2001
      ------------------------------------

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</Table>

<PAGE>   4

                                  INSTRUCTIONS

     FORMING PART OF THE TERMS AND CONDITIONS OF THIS LETTER OF TRANSMITTAL

         1. Use of Letter of Transmittal. This Letter of Transmittal, properly
completed and duly executed, together with the surrendered Certificate(s) and
any documents required by this Letter of Transmittal, should be sent by mail or
overnight courier or delivered by hand to the Exchange Agent in order to make
an effective surrender. Until all necessary steps have been taken to surrender
the Certificate(s), no exchange shall be made. The method of delivery of all
documents is at the option and risk of the undersigned and the delivery will be
deemed made only when actually received. If delivery is by mail, registered
mail with return receipt requested, properly insured, is recommended. A return
envelope is enclosed for your convenience.

         2. Guarantee of Signatures. If this Letter of Transmittal is signed by
the registered holder(s) of the Certificate(s) tendered therewith and such
holder(s) have not completed the "Special Issuance Instructions" or "Special
Delivery Instructions" above, signatures on this Letter of Transmittal are not
required to be guaranteed. In all other cases, signatures on this Letter of
Transmittal must be guaranteed in accordance with Rule 17Ad-15 (promulgated
under the Securities Exchange Act of 1934, as amended (the "Exchange Act") by
an eligible guarantor institution which is a participant in a stock transfer
association recognized program, such as a firm that is a member of a registered
national securities exchange, a member of the National Association of
Securities Dealers, Inc., by a commercial bank or trust company having an
office or correspondent in the United States or by an international bank,
securities dealer, securities broker or other financial institution licensed to
do business in its home country (an "Eligible Institution").

         3. Signatures on this Letter of Transmittal, Powers of Attorney and
Endorsements.

         (a)      If this Letter of Transmittal is signed by the registered
                  holder(s) of the Certificate(s) delivered herewith, the
                  signature(s) of the holder on this Letter of Transmittal must
                  correspond exactly with the name(s) as written on the face of
                  the Certificate(s) without alteration, or any change
                  whatsoever.

         (b)      If any Certificate(s) are held or owned of record by two or
                  more joint owners, all such owners must sign this Letter of
                  Transmittal.

         (c)      Do not endorse the Certificate(s) if the Company Common Stock
                  certificate is to be issued in the name of the registered
                  holder(s) unless the registered holder(s) is/are completing
                  the Special Issuance Instructions.

         (d)      If the certificate(s) of the Company Common Stock is to be
                  issued in the name of a person other than the signer of a
                  Letter of Transmittal, then the Certificate(s) surrendered in
                  exchange therefor must be endorsed or accompanied by an
                  appropriate instrument of transfer signed exactly as the name
                  of the registered owner appears on such Certificate(s), with
                  the signatures on the endorsement or instrument of transfer
                  guaranteed by an Eligible Institution (unless signed by an
                  Eligible Institution).

<PAGE>   5

         (e)      If this Letter of Transmittal or any proxy is signed by a
                  trustee, executor, administrator, guardian, attorney-in-fact,
                  officer of a corporation or other person acting in a
                  fiduciary or representative capacity, such person must so
                  indicate when signing, and proper evidence satisfactory to
                  the Company of their authority to so act must be submitted.

         (f)      If this Letter of Transmittal is signed by a person other
                  than the registered holder(s) of the Certificate(s) listed,
                  the Certificate(s) must be endorsed or accompanied by an
                  appropriate instrument of transfer, in either case signed
                  exactly as the name(s) of the registered holder(s) appear(s)
                  on the Certificate(s). Signatures on such Certificate(s) or
                  instrument of transfer must be guaranteed by an Eligible
                  Institution (unless signed by an Eligible Institution).

         4. Special Issuance and Special Delivery Instructions. If the Company
Common Stock is to be issued and paid to someone other than the holder or
mailed to an address other than that shown above, the appropriate boxes on this
Letter of Transmittal should be completed.

         5. Irregularities. All questions as to the form of documents and the
validity of the Certificate(s) will be resolved by the Company, in its sole
discretion, whose determination shall be final and binding. The Company
reserves the absolute right to reject any deliveries of any Certificate(s) for
exchange that are not in proper form, or the acceptance of which would, in the
opinion of the Company or its counsel, be unlawful. The Company reserves the
absolute right to waive any defect or irregularity of delivery for exchange
with regard to any Certificate(s).

         6. Mutilated, Lost, Stolen or Destroyed Certificate(s). Any holder
whose Certificate(s) have been mutilated, lost, stolen or destroyed should
complete this Letter of Transmittal and the attached Lost Certificate Affidavit
and Indemnity Agreement indicating that his/her Certificate(s) has/have been
mutilated, lost, stolen or destroyed.

         7. Requests for Assistance or Additional Copies. Requests for
assistance or for additional copies of this Letter of Transmittal may be
directed to Benchmark at the address or telephone number set forth on the cover
of this Letter of Transmittal.

         8. Representations and Warranties. The holder of the Certificate(s)
represent and warrant to the Company that, to the best of his/her knowledge,
each of the following are true and correct:

         (a)      Purchase Entirely for Own Account. The shares of Company
                  Common Stock to be acquired by the holder of the
                  Certificate(s) as part of the Merger Consideration will be
                  acquired for investment for the holder's own respective
                  accounts, not as a nominee or agent, and not with a view to
                  the resale or distribution of any part thereof, and that the
                  holder has no present intention of selling, granting any
                  participation in or otherwise distributing the same. By
                  executing this Letter of Transmittal, the holder of the
                  Certificate(s) further represent that the holder does not
                  have any contract, undertaking, agreement or arrangement with
                  any person to sell, transfer or grant participations to such
                  person or to any third person, with respect to any of the
                  shares of Company Common Stock to be acquired by him/her as
                  part of the Merger Consideration.

         (b)      Disclosure of Information. The holder of the Certificate(s)
                  believes he/she has received all the information he/she
                  consider necessary or appropriate for deciding whether
                  participate in the exchange of the Certificate(s) as
                  described in the Merger Agreement

<PAGE>   6

                  and this Letter of Transmittal. The holder of the
                  Certificate(s) further represent that he/she has had an
                  opportunity to ask questions and receive answers from the
                  Company regarding the terms and conditions of the exchange of
                  the Certificate(s) and the business, properties, prospects
                  and financial condition of the Company.

         (c)      Investment Experience. The holder of the Certificate(s) is an
                  investor in securities of companies in the development stage
                  and each acknowledges that he/she is able to bear the
                  economic risk of this investment, and has such knowledge and
                  experience in financial or business matters that it is
                  capable of evaluating the merits and risks of the investment
                  in the Company Common Stock.

         (d)      Accredited Investor. The holder of the Certificate(s) is an
                  "accredited investor" within the meaning of Securities and
                  Exchange Commission Rule 501 of Regulation D, as presently in
                  effect.

         (e)      Restricted Securities. The holder of the Certificate(s)
                  understands that the shares of the Company Common Stock that
                  he/she will received as a result of Merger are characterized
                  as "restricted securities" under the federal securities laws
                  inasmuch as they are being acquired from the Company in a
                  transaction not involving a public offering and that under
                  such laws and applicable regulations such shares may be
                  resold without registration under the Securities Act only in
                  certain limited circumstances. In the absence of an effective
                  registration statement covering the shares of Company Common
                  Stock or an available exemption from registration under the
                  Securities Act, the shares must be held indefinitely. The
                  holder of the Certificate(s) represents that he/she is
                  familiar with Exchange Act Rule 144, as presently in effect,
                  and understands the resale limitations imposed thereby and by
                  the Securities Act, including without limitation the Rule 144
                  condition that current information about the Company be
                  available to the public.

         (f)      Tax Advisors. The holder of the Certificate(s) has reviewed
                  with his/her own tax advisors the federal, state and local
                  tax consequences of the Merger, where applicable, and the
                  exchange of the Certificate(s) as described in the Merger
                  Agreement and this Letter of Transmittal. The holder of the
                  Certificate(s) is relying solely on such advisors and not on
                  any statements or representations of the Company, Isolagen,
                  Gemini or any of their agents and understands that the holder
                  of the Certificate(s) (and not the Company, Isolagen or
                  Gemini) shall be responsible for the holder's own respective
                  tax liabilities that may arise as a result of the Merger or
                  the exchange of the Certificate(s).

         (g)      Legal Counsel. The holder of the Certificate(s) acknowledges
                  that he/she has had the opportunity to review the Merger
                  Agreement, the exhibits and the schedules attached thereto,
                  and the transactions contemplated therein with his/her own
                  legal counsel.

                           IMPORTANT TAX INFORMATION

         A holder who delivers Certificate(s) for exchange is required to
provide the Company (as payer), through the Exchange Agent, with the holder's
correct taxpayer identification number ("TIN") on Substitute Form W-9 or
otherwise establish a basis for exemption from backup withholding. Generally,
if the holder is an individual, the TIN is the holder's social security number.
If the Exchange Agent is not provided with the correct taxpayer identification
number, the holder may be subject to a $50 penalty, as well as various other
penalties, imposed by the Internal Revenue Service. In addition, payments made

<PAGE>   7

to the holder with respect to the Company Common Stock may be subject to backup
withholding.

         Certain holders (including, among others, all corporations and certain
foreign individuals) are not subject to these backup withholding and reporting
requirements. Exempt holders should indicate their exempt status on Substitute
Form W-9. A foreign individual may qualify as an exempt recipient or other
payee by submitting to the Exchange Agent a properly completed Internal Revenue
Service Form W-8 signed under penalty of perjury, attesting to the holder's
exempt status.

         If backup withholding applies, the Company is required to withhold 31%
of any payment made to the holder or other payee. Backup withholding is not an
additional federal income tax. Rather, the amount withheld will be credited
against the federal income tax liability of persons subject to backup
withholding. If withholding results in an overpayment of taxes, a refund may be
obtained from the Internal Revenue Service provided that the required
information is timely furnished to the Internal Revenue Service.

PURPOSE OF SUBSTITUTE FORM W-9

         To prevent backup withholding on payments that are made to a holder
with respect to the Company Common Stock, the holder is required to provide the
Exchange Agent with either: (i) the holder's correct TIN by completing the form
below, certifying that the TIN provided on Substitute Form W-9 is correct (or
that the holder is awaiting a TIN) and that (A) the holder has not been
notified by the Internal Revenue Service that he or she is subject to backup
withholding as a result of failure to report all interest or dividends or (B)
the Internal Revenue Service has notified the holder that he or she is no
longer subject to backup withholding; or (ii) an adequate basis for exemption.

WHAT NUMBER TO GIVE THE EXCHANGE AGENT

         The holder is required to give the Exchange Agent the TIN (e.g.,
social security number or employer identification number) of the record owner
of the Certificate(s).

<PAGE>   8

                 TO BE COMPLETED BY ALL HOLDERS OF CERTIFICATES
             (See Instruction 5 and "Important Tax Information" on
                          this Letter of Transmittal)

<Table>
<Caption>
-------------------------------------------------------------------------------------------------------------------------
                                       PAYER'S NAME: AMERICAN FINANCIAL HOLDING, INC.
-------------------------------------------------------------------------------------------------------------------------
<S>                                     <C>                                                <C>
           SUBSTITUTE                   Part 1--PLEASE PROVIDE YOUR TIN IN THE BOX          Social Security Number
            FORM W-9                    AT RIGHT AND CERTIFY BY SIGNING AND DATING
   Department of the Treasury           BELOW.                                                    -----------
   Internal Revenue Service
                                                                                                    OR

                                                                                           Employer Identification Number

                                                                                                  -----------

                                        ----------------------------------------------------------------------------------

                                        Name (Please Print)
                                                           ---------------------------------------------------------------
   Payer's Request for Taxpayer
                                        Address
 Identification Number (TIN) and        ----------------------------------------------------------------------------------

           Certificate                  ----------------------------------------------------------------------------------

                                        ----------------------------------------------------------------------------------
                                        City                                 State                            ZIP Code
                                        ----------------------------------------------------------------------------------

                                        Part 2--Awaiting TIN [ ]
--------------------------------------------------------------------------------------------------------------------------
</Table>

PART 3--CERTIFICATION--UNDER THE PENALTIES OF PERJURY, I CERTIFY THAT (1) the
number shown on this form is my correct taxpayer identification number (or a
TIN has not been issued to me but I have mailed or delivered an application to
receive a TIN or intend to do so in the near future), (2) I am not subject to
backup withholding either because I have not been notified by the Internal
Revenue Service (the "IRS") that I am subject to backup withholding as a result
of a failure to report all interest or dividends or the IRS has notified me
that I am no longer subject to backup withholding, and (3) all other
information provided on this form is true, correct and complete.

Signature                                                  Date
         ---------------------------------------------          ---------------

You must cross out item (2) above if you have been notified by the IRS that you
are currently subject to backup withholding because of under-reported interest
or dividends on your tax return and you have not been advised by the IRS that
such backup withholding has been terminated.
-------------------------------------------------------------------------------

   FAILURE TO COMPLETE AND RETURN THIS FORM MAY RESULT IN BACKUP WITHHOLDING.

               YOU MUST COMPLETE THE FOLLOWING CERTIFICATE IF YOU
                CHECKED THE BOX IN PART 2 OF SUBSTITUTE FORM W-9

<PAGE>   9
-------------------------------------------------------------------------------
             CERTIFICATE OF AWAITING TAXPAYER IDENTIFICATION NUMBER

I certify under the penalties of perjury that a taxpayer identification number
has not been issued to me, and either (a) I have mailed or delivered an
application to receive a taxpayer identification number to the appropriate
Internal Revenue Service Center or Social Security Administration Office or (b)
I intend to mail or deliver an application in the near future. I understand
that if I do not provide a taxpayer identification number within sixty (60)
days, 31% of all reportable payments made to me thereafter will be withheld
until I provide a number.

Signature                                     Date
         -----------------------------------      ----------------------------
-------------------------------------------------------------------------------

<PAGE>   10

               LOST CERTIFICATE AFFIDAVIT AND INDEMNITY AGREEMENT

         The undersigned, being duly sworn, deposes and says:

         1. I familiar with the facts herein certified and am duly authorized
to certify the same.

         2. The undersigned is the registered owner of __________ shares of the
issued and outstanding common stock, par value $0.0001 per share (the "Common
Stock"), of Gemini IX, Inc., a Delaware corporation (the "Company").

         3. Certificate Number _________ (the "Stock Certificate"), representing
_______ shares of the Common Stock, has been lost, mislaid, stolen or destroyed,
and the undersigned, after attempting diligently and in good faith to locate the
Stock Certificate, has been unable to do so. The undersigned has no present
knowledge as to the whereabouts of the Stock Certificate.

         4. In order to allow the undersigned to transfer and surrender the
shares of Common Stock evidenced by the Stock Certificate unto the Company and
American Financial Holding, Inc., a Delaware corporation ("AFH"), the Company
and AFH have agreed that they will accept this Lost Certificate Affidavit and
Indemnity Agreement (the "Agreement") in lieu of the Stock Certificate.

         5. The undersigned now executes this Agreement so that he, she or it
may submit this Agreement in lieu of the Stock Certificate to the Company and
AFH in order to transfer and surrender the shares of Common Stock evidenced by
the Stock Certificate unto the Company and AFH.

         6. The Stock Certificate has not been endorsed by the undersigned,
either in blank or to any person or entity. The undersigned has not sold,
assigned, transferred, hypothecated, pledged, negotiated or otherwise disposed
of the Stock Certificate, in whole or in part, nor any of his, her or its
interest in or right to the Stock Certificate.

         7. There are no outstanding liens, security interests, encumbrances,
or the like on the Stock Certificate or the shares represented thereby, nor has
the undersigned agreed to forbear any action that the undersigned may have a
right to take with respect to it or them.

         8. There are no attachments or executions levied on the Stock
Certificate or the shares of Common Stock represented thereby and no
bankruptcy, insolvency, receivership, or sequestration proceedings are pending
against the undersigned. No application has been made to the appointment of a
committee or guardian for the undersigned's property.

         9. The undersigned is the sole owner of the Stock Certificate and the
shares of Common Stock represented thereby and no other person, firm or
corporation has any ownership interest, right, title, or claim in law or in
equity in the Stock Certificate, the shares represented thereby, or in their
proceeds.

         10. In consideration of the foregoing, the undersigned hereby agrees
for himself, herself or itself and for his, her or its legal representatives,
successors and assigns, at all times to indemnify and hold harmless the
Company, AFH, Isolagen Technologies, Inc., a Delaware corporation, and their
parent and subsidiary entities, if any, and their respective officers,
directors, employees, agents, successors in interest, assigns and affiliates
(collectively, the "Indemnified Parties") from and against any and all claims,
actions and suits, whether groundless or otherwise, and against any and all
liabilities, losses, damages, costs, charges (including attorneys' fees),
payments and expenses of every nature and character, arising by reason of (i)
any claim which may be made in respect of the Stock Certificate or any
obligation with respect to the Stock Certificate; (ii) any payment, transfer,
delivery, exchange or other act that any Indemnified Party may make or do in
respect of the Stock Certificate, whether made or done through accident,
oversight or neglect or whether made or done upon presentation thereof without
contesting the propriety of such payment, transfer, delivery, exchange or other
act; (iii) any prior or subsequent transfer of the Stock Certificate or any
right or interest therein; or (iv) any other matter arising out of this
Agreement.

<PAGE>   11

         11. The undersigned further agrees for himself, herself or itself and
for his, her or its legal representatives, successors and assigns, that if the
Stock Certificate comes into the hands or power of any of them, said the Stock
Certificate shall be delivered to the Company or AFH, or their successors in
interest, without further obligation or liability on the part of the Company or
AFH.

         12. This Agreement shall be construed in accordance with the laws of
the State of Texas without reference to its conflicts of laws principles.

         13. This Agreement shall be binding on the undersigned and the
undersigned's successors and assigns, beneficiaries, legatees and
representatives.

         IN WITNESS WHEREOF, this Agreement is executed effective the _____ day
of _______________, 2001.

                                   Signature:
                                             ----------------------------------
                                   Printed Name:
                                                -------------------------------
                                   Title:
                                         --------------------------------------

-----------------------------
Sworn to before me this
day of                        , 2001.
       -----------------------

-----------------------------
Notary Public for
                  -----------

[SEAL]<PAGE>   1
                                                                     EXHIBIT 4.1

              THIS NOTE IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE
HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITORY OR A
NOMINEE OF A DEPOSITORY. THIS NOTE IS EXCHANGEABLE FOR NOTES REGISTERED IN THE
NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED
CIRCUMSTANCES DESCRIBED IN THE INDENTURE AND MAY NOT BE TRANSFERRED EXCEPT AS A
WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY OR BY A NOMINEE OF THE
DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE DEPOSITORY.

              UNLESS THIS NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF
THE DEPOSITORY TRUST COMPANY ("DTC") (55 WATER STREET, NEW YORK, NEW YORK) TO
THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT AND
ANY NOTE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS IS
REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC AND ANY PAYMENT IS MADE TO CEDE
& CO., OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE
OF DTC, ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO
ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS
AN INTEREST HEREIN. UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR THE
INDIVIDUAL NOTES REPRESENTED HEREBY, THIS GLOBAL NOTE MAY NOT BE TRANSFERRED
EXCEPT AS A WHOLE BY DTC TO A NOMINEE OF DTC OR BY A NOMINEE OF DTC TO DTC OR
ANOTHER NOMINEE OF DTC OR BY DTC OR ANY SUCH NOMINEE TO A SUCCESSOR OF DTC OR A
NOMINEE OF SUCH SUCCESSOR.

<PAGE>   2
                                                           Cusip No. 12201P AC 0

                      BURLINGTON RESOURCES FINANCE COMPANY
                                   6.40% NOTES
                               DUE AUGUST 15, 2011

<Table>
<Caption>
Rate of Interest                  Maturity Date              Original Issue Date
----------------                  -------------              -------------------
<S>                              <C>                           <C>
     6.40%                       August 15, 2011               August 24, 2001

No. 001                                                         $[        ]
</Table>

              Burlington Resources Finance Company, an unlimited liability
company organized and existing under the laws of Nova Scotia, Canada (herein
called the "Company"), for value received, hereby promises to pay to Cede & Co.
or registered assigns, the principal sum of $[ ] on the Maturity Date shown
above, and to pay interest thereon, at the annual rate of interest shown above,
from the Original Issue Date shown above or from the most recent Interest
Payment Date (as hereinafter defined) to which interest has been paid or duly
provided for, payable semiannually on February 15 and August 15 of each year and
at maturity (an "Interest Payment Date"), commencing on the first such date
after the Original Issue Date shown above. Interest will be computed on the
basis of a 360-day year of twelve 30-day months.

              The interest so payable, and punctually paid or duly provided for,
on any Interest Payment Date or within five days thereafter will, as provided in
the Indenture, be paid to the person in whose name this Note is registered at
the close of business on the Record Date for any such Interest Payment Date,
which shall be the February 1 or August 1 next preceding the applicable Interest
Payment Date (whether or not a Business Day). Any such interest not so
punctually paid or duly provided for, and any interest payable on such defaulted
interest (to the extent lawful), will forthwith cease to be payable to the
Holder on such Record Date and shall be paid to the person in whose name this
Note is registered at the close of business on a special record date for the
payment of such defaulted interest to be fixed by the Trustee, notice of which
shall be given to Holders of Notes not less than ten days prior to such special
record date. Payment of the principal of (and premium, if any) and interest on
this Note will be made at the office of the Trustee, in such coin or currency of
the United States of America as at the time of payment is legal tender for
payment of public and private debts; provided, however, that, at the option of
the Company, payment of any installment of interest may be made by check mailed
to the address of the person entitled thereto as such address shall appear in
the Securities Register or by wire transfer to an account maintained by the
person entitled thereto as specified in the Securities Register, provided that
such person shall have given the Trustee appropriate and timely written wire
instructions.
<PAGE>   3

              REFERENCE IS HEREBY MADE TO THE FURTHER PROVISIONS OF THIS NOTE
SET FORTH ON THE REVERSE HEREOF, WHICH FURTHER PROVISIONS SHALL FOR ALL PURPOSES
HAVE THE SAME EFFECT AS IF SET FORTH AT THIS PLACE.

              Unless the certificate of authentication hereon has been executed
by the Trustee referred to on the reverse hereof by manual signature, this Note
shall not be entitled to any benefit under the Indenture or be valid or
obligatory for any purpose.

<PAGE>   4
                  IN WITNESS WHEREOF, Burlington Resources Finance Company has
caused this instrument to be executed in its corporate name by the facsimile
signature of its duly authorized officers and has caused a facsimile of its
corporate seal to be affixed hereunto or imprinted hereon.

                                       BURLINGTON RESOURCES FINANCE COMPANY

                                       By:
                                          --------------------------------------
                                           Name:  Daniel D. Hawk
                                           Title: Vice President and Treasurer

ATTEST:

By:
   ----------------------------------
    Name:  Anne Vaughan
    Title: Assistant Secretary

DATED:

<PAGE>   5
                     TRUSTEE'S CERTIFICATE OF AUTHENTICATION

              This is one of the 6.40% Notes due August 15, 2011 issued pursuant
to the within-mentioned Indenture.

                                       CITIBANK, N.A.,
                                         as Trustee

                                       By:
                                          --------------------------------------
                                           Authorized Signatory
                                           Dated:

<PAGE>   6
                      BURLINGTON RESOURCES FINANCE COMPANY
                                   6.40% NOTES
                               DUE AUGUST 15, 2011

              This Note is one of a duly authorized issue of Notes of the
Company (which term includes any successor Person under the Indenture herein
referred to) designated as its 6.40% Notes due August 15, 2011 (the "Notes"),
issued or to be issued pursuant to an Indenture, dated as of February 12, 2001
(the "Indenture"), between the Company and Citibank N.A., as Trustee (the
"Trustee," which term includes any successor trustee under the Indenture). The
Notes shall be fully and unconditionally guaranteed by Burlington Resources
Inc., a Delaware corporation (the "Guarantor"), pursuant to a Guarantee
Agreement dated as of February 12, 2001 by the Guarantor in favor of the holders
of Notes. The terms of this Note include those stated in the Indenture and in
the Officers' Certificate issued thereunder and those made part of the Indenture
by reference to the Trust Indenture Act of 1939, as in effect on the date of the
Indenture. Reference is hereby made to the Indenture and the applicable
officers' certificate issued thereunder for a statement of the respective
rights, limitation of rights, duties and immunities thereunder of the Company,
the Trustee and the Holders and of the terms upon which the Notes are, and are
to be, authenticated and delivered.

              The Notes are a series of Securities issued or to be issued by the
Company under the Indenture, and this Series is unlimited in aggregate principal
amount. As of the Original Issue Date, $[ ] principal amount of Notes of this
Series will be issued. The Indenture provides that the Securities of the Company
referred to therein ("Securities"), may be issued in one or more Series, which
different Series may be issued in such aggregate principal amounts and on such
terms (including, but not limited to, terms relating to interest rate or rates,
provisions for determining such interest rate or rates and adjustments thereto,
maturity, redemption (optional and mandatory), covenants and Events of Default)
as may be provided in the officers' certificates or supplemental indentures
relating to the several Series.

              The Notes are subject to redemption upon not less than 30 nor more
than 60 days notice by mail, in whole or in part, at the option of the Company
at any time at a redemption price equal to the greater of (i) 100% of the
principal amount of such Notes plus accrued and unpaid interest to the
redemption date or (ii) the sum of the present values of the remaining scheduled
payments of principal and interest thereon (exclusive of interest accrued to the
date of redemption) discounted to the redemption date on a semiannual basis
(assuming a 360-day year consisting of twelve 30-day months) at the Treasury
Rate plus 25 basis points plus accrued and unpaid interest thereon to the
redemption date.

              "Treasury Rate" means, with respect to any redemption date, (i)
the yield, under the heading which represents the average for the immediately
preceding week, appearing in the most recently published statistical release
designated "H.15(519)" or any successor publication which is published weekly by
the Board of Governors of the Federal Reserve System and which establishes
yields on actively traded United States Treasury securities adjusted to constant
maturity under the caption "Treasury Constant Maturities," for the maturity
corresponding to the Comparable Treasury Issue (if no maturity is within three
months before or after the Remaining Life, yields for the two published

<PAGE>   7
                                       -2-

maturities most closely corresponding to the Comparable Treasury Issue shall be
determined and the Treasury Rate shall be interpolated or extrapolated from such
yields on a straight line basis, rounding to the nearest month) or (ii) if such
release (or any successor release) is not published during the week preceding
the calculation date or does not contain such yields, the rate per annum equal
to the semiannual equivalent yield to maturity of the Comparable Treasury Issue,
calculated using a price for the Comparable Treasury Issue (expressed as a
percentage of its principal amount) equal to the Comparable Treasury Price for
such redemption date. The Treasury Rate shall be calculated on the third
Business Day preceding the redemption date.

              "Business Day" means any calendar day that is not a Saturday,
Sunday or legal holiday in New York, New York and on which commercial banks are
open for business in New York, New York.

              "Comparable Treasury Issue" means the United States Treasury
security selected by an Independent Investment Banker as having a maturity
comparable to the remaining term ("Remaining Life") of the Notes to be redeemed
that would be utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of corporate debt securities
of comparable maturity to the remaining term of the Notes.

              "Comparable Treasury Price" means, with respect to any redemption
date, (A) the average of four Reference Treasury Dealer Quotations for such
redemption date, after excluding the highest and lowest such Reference Treasury
Dealer Quotations, or (B) if the Independent Investment Banker obtains fewer
than four such Reference Treasury Dealer Quotations, the average of all such
Quotations.

              "Independent Investment Banker" means Salomon Smith Barney Inc. or
if such firm is unwilling or unable to select the Comparable Treasury Issue, an
independent investment banking institution of national standing appointed by the
Trustee.

              "Reference Treasury Dealer" means (i) each of Salomon Smith Barney
Inc. and three other primary U.S. Government securities dealers in New York City
(each, a "Primary Treasury Dealer") and their respective successors, provided,
however, that if any of the foregoing shall cease to be a Primary Treasury
Dealer, the Company will substitute therefor another Primary Treasury Dealer and
(ii) any other Primary Treasury Dealer selected by the Company.

              "Reference Treasury Dealer Quotations" means, with respect to each
Reference Treasury Dealer and any redemption date, the average, as determined by
the Independent Investment Banker, of the bid and asked prices for the
Comparable Treasury Issue (expressed in each case as a percentage of its
principal amount) quoted in writing to the Independent Investment Banker by such
Reference Treasury Dealer at 5:00 p.m. on the third Business Day preceding such
redemption date.

              If an Event of Default shall occur and be continuing, the
principal of all the Notes may be declared due and payable in the manner and
with the effect provided in the Indenture. The Indenture provides that the
Trustee or Holders of at least 25% in principal amount of the Securities of
<PAGE>   8
                                       -3-

the applicable series may declare the applicable series to be immediately due
and payable. However, upon certain conditions such declarations may be annulled
and past defaults may be waived.

              The Indenture permits, with certain exceptions as therein
provided, the amendment thereof and the modification of the rights and
obligations of the Company and the rights of the Holders of the Notes under the
Indenture at any time by the Company and the Trustee with the consent of the
Holders of a majority in aggregate principal amount of the Securities affected
thereby, voting as a single class (which may include the Notes), at the time
outstanding. The Indenture also contains provisions permitting the Company and
the Trustee to amend certain provisions of the Indenture without the consent of
the Holders of the Securities.

              No reference herein to the Indenture or the Officers' Certificate
and no provision of this Note or of the Indenture or the Officers' Certificate
shall alter or impair the obligation of the Company, which is absolute and
unconditional, to pay the principal of and interest on this Note at the times,
places and rates, and in the coin or currency, herein prescribed.

              As provided in the Indenture and subject to certain limitations
therein set forth, the transfer of this Note is registrable in the Securities
Register upon surrender of this Note for registration of transfer at the agency
of the Company provided for that purpose duly endorsed by, or accompanied by a
written instrument of transfer in substantially the form accompanying this Note
duly executed by, the Holder hereof or his attorney duly authorized in writing,
and thereupon one or more new Notes, of authorized denominations and for the
same aggregate principal amount, will be issued to the designated transferee or
transferees.

              The Notes are issuable only in registered form without coupons in
denominations of $1,000 and any integral multiple thereof. As provided in the
Indenture and subject to certain limitations set forth therein and on the face
of this Note, the Notes are exchangeable for a like aggregate principal amount
of Notes of a different authorized denomination, as requested by the Holder
surrendering the same.

              No service charge shall be made for any such registration of
transfer or exchange, but the Company may require payment of a sum sufficient to
cover any transfer tax or similar governmental charge payable in connection
therewith (other than any such transfer tax or similar governmental charge
payable upon exchanges pursuant to the Indenture in which case such transfer
taxes or similar governmental charges shall be paid by the Company).

              Prior to due presentment of this Note for registration of
transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the person in whose name this Note is registered as the owner hereof
for all purposes, whether or not this Note be overdue, and neither the Company,
the Trustee nor any such agent shall be affected by notice to the contrary.

              All terms used in this Note which are defined in the Indenture or
the Officers' Certificate shall have the meanings assigned to them therein.

<PAGE>   9
                                       -4-

              Customary abbreviations may be used in the name of a Note holder
or any assignee, such as: TEN COM (= tenants in common), TEN ENT(= tenants by
the entireties), JT TEN (= joint tenants with right of survivorship and not as
tenants in common), CUST (= Custodian) and U/G/M/A (Uniform Gifts to Minors
Act).

              The Company will furnish to any Holder of record of a Note, upon
written request, without charge, a copy of the Indenture. Requests may be made
to: Vice President and Assistant Treasurer, Burlington Resources Finance
Company, c/o Burlington Resources Canada Energy Ltd., Suite 3700, 250-6th
Avenue, S.W., Calgary, Alberta T2P 3H7, telephone: (403) 260-8000.

<PAGE>   10
                                 ASSIGNMENT FORM

              If you the Holder want to assign this Note, fill in the form below
and have your signature guaranteed:

I or we assign and transfer this Note to:

________________________________________________________________________________

________________________________________________________________________________

________________________________________________________________________________
        (Print or type name, address and zip code and social security or
                          tax ID number of assignees)

and irrevocably appoint ________________________________________________________
agent to transfer this Note on the books of the Company. The agent may
substitute another to act for him.

Dated:                                    Signed:
      ---------------------------------          -------------------------------

                                                 -------------------------------
                                                  (Sign exactly as name appears
                                                  on the other side of the Note)

Signature Guarantee:
                    ------------------------------------------------------------

              NOTICE: Signature(s) must be guaranteed by a member firm of the
New York Stock Exchange or a commercial bank or trust company.

<PAGE>   11

                              [FORM OF GUARANTEE]

                                   GUARANTEE

              The undersigned Guarantor (capitalized terms used herein have the
meanings given such terms in the Indenture referred to in the Note upon which
this notation is endorsed) hereby unconditionally guarantees (such guarantee
being referred to herein as the "Guarantee") the due and punctual payment of the
principal of, premium, if any, and interest on the 6.40% Notes due August 15,
2011 (the "Notes") which this Guarantee accompanies, whether at maturity, by
acceleration or otherwise, the due and punctual payment of interest on the
overdue principal, premium and interest on the Notes, and the due and punctual
performance of all other obligations of the Company to the Holders or the
Trustee, all in accordance with the terms set forth in Article Two of the
Guarantee Agreement.

              This Guarantee shall not be valid or obligatory for any purpose
until the certificate of authentication on the Notes upon which this Guarantee
is noted shall have been executed by the Trustee under the Indenture by the
manual signature of one of its authorized officers.

              This Guarantee shall be governed by and construed in accordance
with the laws of the State of New York.

              This Guarantee is subject to release upon the terms set forth in
the Guarantee Agreement.

                                       BURLINGTON RESOURCES INC.

                                       By:
                                          --------------------------------------
                                           Name:
                                           Title:

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