Document:

Exhibit 10.9

 Exhibit 10.9 
 *** Text Omitted and Filed Separately 
 Confidential Treatment Requested 

Under 17 CFR §§ 200.80(b)(4) and 230.406 
 COLLABORATION AGREEMENT 
 BY AND BETWEEN 

LIPOSCIENCE, INC. 
 AND 
 VARIAN, INC. 

DATED AS OF APRIL 22, 2005 

 *** Text Omitted and Filed Separately 

Confidential Treatment Requested 
 Under 17 CFR §§ 200.80(b)(4) and 230.406 
  

 COLLABORATION AGREEMENT 
 THIS COLLABORATION AGREEMENT (the “Agreement”) dated as of April 22, 2005 (the “Effective Date”), is made by and between LIPOSCIENCE, INC., a corporation organized
and existing under the laws of the State of Delaware having its offices at 2500 Sumner Boulevard, Raleigh, North Carolina 27616 (“LipoScience”), and VARIAN, INC., a corporation organized and existing under the laws of the State of Delaware
having its offices at 3120 Hansen Way, Palo Alto, CA 94304 (“Varian”). LipoScience and Varian are sometimes referred to herein individually as a “Party” and collectively as the “Parties.” 

R E C I T A L S 
 WHEREAS, LipoScience has developed and marketed the NMR
LipoProfile® test, a clinical diagnostic tool which uses NMR Technology and has experience and expertise in
developing, utilizing and marketing clinical diagnostic applications utilizing NMR Technology; and 
 WHEREAS, Varian develops
and commercializes certain NMR Technology and has extensive experience and expertise in the development and use of NMR Technology; and 
 WHEREAS, the Parties wish to cooperate in a strategic collaboration to develop an integrated NMR system and to commercialize such NMR system on a worldwide basis in the clinical diagnostic and other
fields; and 
 WHEREAS, the Parties intend that this collaboration be based upon joint contributions by each Party, sharing of
intellectual property and expertise and sharing of the anticipated benefits of the collaboration. 
 NOW THEREFORE, in
consideration of the premises and of the mutual covenants herein contained, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereto agree as follows: 

ARTICLE 1 DEFINITIONS 

For purposes of this Agreement, the terms defined in this Article shall have the meanings specified below, whether used in their singular or plural form:

 1.1 “Affiliate” shall mean any corporation or other entity that controls, is controlled by, or is under
common control with a Party to this Agreement. A corporation or other entity shall be regarded as in control of another corporation or entity if it directly or indirectly owns or controls more than fifty percent (50%) of the voting stock or
other ownership interest of the other corporation or entity, or if it possesses, directly or indirectly, the power to direct or cause the direction of the management and policies of the corporation or other entity or the power to elect or appoint
more than fifty percent (50%) of the members of the governing body of the corporation or other entity. 

  
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 1.2 “Approval” shall mean any approval required to be obtained from
applicable regulatory authorities in any jurisdiction in order to lawfully market and sell the Magnus Analyzer or Varian Analyzer in such jurisdiction, including, but not limited to, FDA 510(k) approval for the Magnus Analyzer. The term
“Approved” shall mean the receipt of Approval. 
 1.3 “Autosampler” shall mean the sample-handling
subsystem developed by the Parties for use with the Magnus Analyzer, including, without limitation, subsequent versions, derivatives and as the Autosampler may be adapted by Varian for use with any other NMR system. 

1.4 “Bankruptcy Code” shall mean Title 11 of the United States Code, as amended from time to time. 

1.5 [***] shall have the meaning set forth in Section [***]. 
 1.6 “Confidential Information” shall have the meaning set forth in Section 8.1. 
 1.7 “Control Subsystem” shall mean the software and any hardware developed by the Parties to integrate and control the various subsystems in the Magnus Analyzer; in particular,
integrating and communicating with the NMR Subsystem, the Autosampler and any Diagnostic Applications or other software programs that may be employed with the Magnus Analyzer. 
 1.8 “Development Plan” shall mean the development plan, as may be amended by the Parties from time to time, which shall set forth a strategy and plan for development, manufacturing and
regulatory approval of the Magnus Analyzer, shall indicate which Party shall have responsibility for the various development activities specified therein consistent with the other terms of this Agreement, shall specify the expected timing of such
activities, including the estimated dates of the initiation and completion of such activities, and has been mutually agreed to, in writing, by the Parties as described in Section 2.6, which Development Plan in its initial version is attached
hereto as Exhibit B. 
 1.9 “Diagnostic Application” shall mean any in vitro clinical diagnostic
application comprising spectral acquisition protocols, post-acquisition signal processing, spectral deconvolution algorithms or results reporting software programs, in each case specifically optimized for in vitro clinical diagnostic
applications, and all intellectual property rights therein. As used in the foregoing definition, the term “in vitro diagnostic clinical application” shall mean the analysis of biologic samples conducted outside of a human patient
from whom it was taken for the purpose of screening, diagnosis, prognosis or monitoring of that patient. 
 1.10
“Effective Date” shall mean the date first set forth above in the preamble. 
  
 [***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
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 1.11 “FDA” shall mean the United States Food and Drug Administration or any
successor agency with responsibilities comparable to those of the United States Food and Drug Administration. 
 1.12
“Joint Developments” shall have the meaning set forth in Section 4.2.3. 
 1.13 “Jointly-Owned
Developments” shall have the meaning set forth in Section 4.2.3. 
 1.14 “LipoScience
Developments” shall have the meaning set forth in Section 4.2.2. 
 1.15 “LipoScience
Diagnostic Application” shall mean any Diagnostic Application which has been developed or acquired by LipoScience as of the Effective Date or is developed or acquired by LipoScience during the Term, including without limitation, the NMR
LipoProfile® test and all improvements thereto. 

1.16 “LipoScience Field of Use” shall mean the use of the NMR Technology with any Diagnostic Application, specifically
with the purpose of [***] or [***] of a [***], and for which [***] or a [***] typically [***] or [***] the [***]. 
 1.17
“LipoScience Collaboration IP” shall mean the LipoScience Pre-Existing Technology, the LipoScience Developments and those Joint Developments assigned to LipoScience, pursuant to Section 4.2.3, and the Jointly-Owned
Developments. 
 1.18 “Magnus Analyzer” shall mean the system using NMR Technology, that is designed and
intended for primary use in the LipoScience Field of Use and which consists of the NMR Subsystem, Autosampler and Control Subsystem, including, without limitation, all subsequent versions, variations, derivatives, modifications and alterations to
such system for use in the LipoScience Field of Use. 
 1.19 “NMR” shall mean nuclear magnet resonance.

 1.20 “NMR Subsystem” shall mean the subsystem for the Magnus Analyzer that comprises a NMR system that
exposes the sample material to magnetic energy and detects the sample’s resonance response and that consists of the [***] (the “NMR Magnet”), the [***] (the “Probe”), the [***] (the “Console”) and the acquisition
software that will communicate with the Control Subsystem. 
 1.21 “NMR Technology” shall mean the technology
relating to NMR Magnets, Consoles, Probes and other hardware, software, parts, accessories, support and services for the NMR Subsystem. 
 1.22 “Oversight Committee” shall have the meaning set forth in Section 2.3. 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
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 1.23 “Patent Rights” shall mean any United States patent or patent
applications, including any continuation, continuations-in-part and divisional application, and any foreign patent or patent application, and any patent, design patent, utility model, inventor certificate, registration or their equivalents issuing
from such United States or foreign patent applications, as well as any renewals, reexaminations, reissues or extensions thereof. 
 1.24 “Pre-Existing Technology” shall mean Patent Rights held by a Party as of the Effective Date and unpatented inventions, know-how, copyrights and other intellectual property which has
been created, developed or acquired by a Party prior to the Effective Date, in each case to the extent it relates to the Magnus Analyzer development contemplated by this Agreement. 

1.25 “Project Manager” shall have the meaning set forth in Section 2.3. 

1.26 “Specification” shall mean the functional and technical specification and requirements for the Magnus Analyzer
(including its subsystems), as contemplated as of the Effective Date, which initial specification is attached as Exhibit A. 

1.27 “Supply Agreement” shall mean the exclusive supply agreement to be subsequently entered into by the Parties, which
agreement will set forth the specific terms and conditions for Varian’s supply of the NMR Subsystems and hardware, software, components, parts, accessories, training, support and services for the NMR Subsystems to LipoScience for the commercial
versions of the Magnus Analyzer. 
 1.28 “System Developer” shall mean the Third Party, which will be
responsible for the overall detailed design of the Magnus Analyzer, including integration of the subsystems and assisting in obtaining FDA Approval. The System Developer may also be the System Manufacturer. 

1.29 “System Manufacturer” shall mean the Third Party which may be responsible for the manufacture of the Magnus
Analyzer; specifically, the manufacture of the Autosampler and the integration of the NMR Subsystem, Autosampler and Control Subsystem. 
 1.30 “Term” shall have the meaning set forth in Section 11.1. 
 1.31 “Territory” shall mean all countries and territories worldwide. 
 1.32 “Third Party” shall mean any person or entity other than LipoScience, Varian or their respective Affiliates. 
 1.33 “Varian Analyzer” shall mean the modified, derivative, altered or related version of the Magnus Analyzer intended for use in the Varian Field of Use. 

1.34 “Varian Developments” shall have the meaning set forth in Section 4.2.1. 

  
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 1.35 “Varian Diagnostic Application” shall mean any Diagnostic Application
that is subsequently developed or acquired by Varian during the Term. 
 1.36 “Varian Field of Use” shall mean
the use of the NMR Technology for all uses, applications and purposes outside of the LipoScience Field of Use, including, without limitation, uses in [***] and [***]. 
 1.37 “Varian Collaboration IP” shall mean the Varian Pre-Existing Technology, the Varian Developments and those Joint Developments assigned to Varian, pursuant to Section 4.2.3, and
the Jointly-Owned Development. 
 ARTICLE 2 COLLABORATION 

2.1 Parties’ Intent. The Parties intend to establish this strategic collaboration for the design, development, marketing and
support of the Magnus Analyzer and its subsystems, including obtaining the necessary Approvals for its use, sale and marketing, specifically FDA Approvals. 
 2.2 General Description of the Magnus Analyzer. The Magnus Analyzer is being designed and developed by the Parties to meet the requirements for use in the LipoScience Field of Use, including
without limitation, the need for high throughput, low cost, high reliability, high serviceability, simplicity and ease of use. The Parties do not intend that the Magnus Analyzer will be a multi-function analyzer; provided, however, that LipoScience
acknowledges that Varian anticipates marketing the Magnus Analyzer, Varian Analyzer and/or Autosampler in the Varian Field of Use, and agrees to consider requests from Varian for additional features or functions for the Magnus Analyzer that may be
useful in the Varian Field of Use. The LipoScience Project Manager, in its sole discretion, may incorporate such requested features or functions into the Specification for the Magnus Analyzer so long as the LipoScience Project Manager determines
that such features or functions will not have a material impact on the Development Plan, the use of the Magnus Analyzer in the LipoScience Field of Use, costs of development or cost of the commercial Magnus Analyzer. It is expected that the Magnus
Analyzer will provide greater ease of use and throughput than current NMR Technology in the LipoScience Field of Use and will function in equivalent manner as other FDA-approved clinical laboratory systems used to perform clinical and
immunochemistry, including pre-test sample handling and conditioning. It is currently anticipated that the Magnus Analyzer will have the capability to process biologic samples which may include one or more of the following: whole blood, serum,
plasma or other blood-derived product, urine, sputum or other fluids or any tissue-derived sample, and provide a clinical result report. It is anticipated that the Magnus Analyzer will utilize typical sample management and bar code identification
for sample tracking and that the result reports will be provided in a variety of media and formats, including visual display via the user interface, paper form and electronically through a laboratory information management system (“LIMS”).
It is anticipated that the lead Diagnostic Application for the Magnus Analyzer will be the NMR LipoProfile. 
 2.3 Project
Manager; Oversight. Each Party will designate in writing to the other Party a project manager and primary contact person (each, a “Project Manager”). The initial Project Managers shall be [***], as representative of LipoScience,
and [***], as representative of Varian. The Project Managers will be responsible for the day-to-day interactions between the Parties related to activities pursuant to the Development Plan and oversight of the day-to-day operations of these
activities; provided, however, that the LipoScience Project Manager will act as the overall program manager for the Magnus Analyzer development and will be responsible 

 
 [***] = Certain information on this page, marked by brackets,
has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  
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for the final development of the Specification and Development Plan (as set forth in Sections 2.5 and 2.6) and coordination of the development activities of the parties. If the Project Managers
deem it to be in the best interest of the collaboration, a joint development team or project group will be formed by the Parties to coordinate and drive the collaboration and development of the Magnus Analyzer. The Project Managers will attempt to
resolve any disputes that arise during the course of developing and implementing the Development Plan; provided, however, that the Project Managers will not have the authority or power to amend this Agreement. If the Project Managers cannot resolve
any such dispute within thirty (30) days (or such longer reasonable period of time as they may agree) after their initial discussion of such issue, the dispute will be submitted to the management of each Party in accordance with
Section 12.7. Each Party may change its Project Manager upon written notice to the other Party. 
 The Parties will also
establish an oversight committee (the “Oversight Committee”) to consist of management representatives from each of LipoScience, Varian and the System Developer as mutually agreed by the Parties. This Oversight Committee will meet either in
person or telephonically at least once during each two-month period. 
 2.4 Responsibilities of the Parties. 

2.4.1. LipoScience. LipoScience will be responsible for the overall design and Specification for the Magnus
Analyzer. LipoScience will have the principal responsibility for the development of the Magnus Analyzer system and NMR Subsystem requirements and will be the principal developer of the LipoScience Diagnostic Applications. In addition, LipoScience
will be responsible for contracting with and managing the development and manufacturing activities of the System Developer and System Manufacturer for the Magnus Analyzer. 

2.4.2. Varian. Varian will be the principal developer of the NMR Subsystem, including the detailed design
requirements therefor. Varian will also have the principal responsibility for design and development of the acquisition software that communicates with the Control Subsystem. Varian will jointly work with the System Developer on development of the
Autosampler and integration of the Autosampler into the NMR Subsystem. In addition, Varian will be responsible for supplying, on an exclusive basis, the NMR Subsystems for the Magnus Analyzer and NMR Technology to LipoScience. 

2.4.3. System Developer. LipoScience will identify and contract with the System Developer; provided, however, that
LipoScience agrees to provide Varian with copies of the proposals received from potential system integrators. Varian will have the right and opportunity to comment and provide input on the selection of the System Developer to LipoScience and as the
Parties will mutually agree on the final choice of System Developer, taking into account factors including cost, quality, and Approval and time requirements for the Magnus Analyzer as well as the reputation and integrity of the System Developer.
Varian hereby acknowledges that LipoScience is currently 

  
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contemplating selecting [***] as the System Developer and hereby approves of the selection of [***] as the System Developer. The System Developer will have detailed design responsibility for:
(i) the Magnus Analyzer frame and support structure, covers and enclosures, and system functions such as power management and distribution, (ii) the Autosampler, including the fluidic management (sample and reagent handling and storage),
sample processing (sample container handling), waste management, process control, and (iii) the LIMS interfacing. The System Developer will be responsible for meeting the requirements of the FDA and other governing regulatory agencies that are
applicable during the development stage. 
 2.4.4. System Manufacturer. The System Manufacturer will be
responsible for manufacturing the prototypes and commercial versions of the Autosampler, and integrating the NMR Subsystem manufactured by Varian, the Autosampler and Control Subsystem to create the Magnus Analyzer. The System Manufacturer may be
responsible for the quality control and manufacturing of all production systems including all system and software validation testing. If the System Developer will not be manufacturing the commercial version of the Magnus Analyzer, Varian will have
the right and opportunity to comment and provide input on the selection of the System Manufacturer to LipoScience, and the Parties will mutually agree on the final choice a System Manufacturer, taking into account factors including cost, quality and
time requirements for the Magnus Analyzer as well as the reputation and integrity of the System Manufacturer. Varian acknowledges that LipoScience is currently contemplating selecting [***] as the System Manufacturer and Varian hereby approves of
the selection of [***] as the System Manufacturer. Each of LipoScience and Varian will enter into separate agreements with the System Manufacturer for the manufacture, purchase and supply of the Magnus Analyzer and/or Autosampler for their
respective Fields of Use, and each Party shall obtain a commitment in its agreement with the System Manufacturer that the other Party will receive purchase and supply terms from the System Manufacturer that are no less favorable than the purchase
and supply terms that it receives from the System Manufacturer. The Parties acknowledge and agree that LipoScience may need to select an alternate System Manufacturer or multiple System Manufacturers (for example, to service a foreign territory) and
the Parties will jointly identify and select such alternate or additional System Manufacturers. 
 2.5 Specification. The
Parties will mutually approve an initial Specification for the Magnus Analyzer, which is attached as Exhibit A. LipoScience will have the primary authority and obligation to develop a final Specification for the Magnus Analyzer; provided, however,
that Varian will have the right to jointly develop and approve the final Specification as it relates to the NMR Subsystem. LipoScience further agrees that it will provide any amendments to the Specification to Varian, and Varian will have the right
to review and provide input on such Specification; provided, however, that other than with respect to the NMR Subsystem (for which Varian shall have the right to approve that portion of the Specification), LipoScience will retain the final decision
on the final Specification for the Magnus Analyzer. 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
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 2.6 Initial Development Plan. The Parties will mutually approve an initial
Development Plan for the Magnus Analyzer, which is attached as Exhibit B. By no later than [***], or such other date as the Project Managers may mutually agree, LipoScience will develop and prepare a final Development Plan for the Magnus Analyzer,
with Varian jointly developing and approving the Development Plan as it relates to the development of the NMR Subsystem and Varian’s obligations under the Development Plan. Such final Development Plan will describe in reasonable detail the
activities to be undertaken by each of the Parties for the Term and will be based on the assumption that the primary goal of the Development Plan is to develop and deliver the Magnus Analyzer for use in the LipoScience Field of Use in a timely and
cost-efficient manner as determined by the LipoScience Project Manager. LipoScience will have the right to amend the Development Plan at any time during the course of development; provided, however, that LipoScience shall not amend the Development
Plan without the prior written approval of the Varian Project Manager if such amendment would have an impact on Varian’s obligations thereunder or otherwise relates to the NMR Subsystem. LipoScience will provide notice and copies of any other
changes to the Development Plan to Varian, and Varian will have the right to review and comment upon such changes. Further, the Parties agree to review the Development Plan on no less than an annual basis and update, as necessary, the Development
Plan. LipoScience and Varian will undertake development activities for the Magnus Analyzer in accordance with the Development Plan. During the course of implementing the Development Plan, LipoScience and Varian will communicate regularly and will
assume certain rights and responsibilities for the development of the Magnus Analyzer as described above in Section 2.4. 

2.7 Regulatory Approvals. LipoScience, solely or with the System Developer or System Manufacturer, will prepare all regulatory
filings for the Magnus Analyzer, including all filings required for FDA Approval in the LipoScience Field of Use, with reasonable input and assistance from Varian, and will be responsible for submitting to the FDA or other regulatory authority such
applications or other filings for Approval, with all such Approvals required for the LipoScience Field of Use in the name of LipoScience. LipoScience will have primary responsibility and final decision-making authority for all regulatory matters
related to the Magnus Analyzer in the LipoScience Field of Use, including communicating with the FDA. Varian will have the right to review and comment upon any such filings and LipoScience will give due consideration to Varian’s
comments. LipoScience will be responsible for obtaining Approvals and for subsequent maintenance of Approvals in the LipoScience Field of Use. Varian will reasonably cooperate with and provide all reasonably requested information and assistance for
such Approvals, including, without limitation, all information and records required for FDA Approval and the European Community In Vitro Diagnostic Directive. Varian will be responsible for submitting, obtaining and maintaining with the appropriate
regulatory authority such applications or other filings for Approval required for the Varian Field of Use, with all such Approvals being in the name of Varian. Varian will have primary responsibility and final decision-making authority for all
regulatory matters related to the Magnus Analyzer and the Varian Analyzer in the Varian Field of Use. LipoScience will have the right to review and comment upon any such filings and Varian will give due consideration to LipoScience’s comments.
LipoScience will reasonably cooperate with and provide all reasonably requested 
  
 [***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
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information and assistance for such Approvals. Each Party will maintain all records and documentation required by the FDA and other applicable regulatory authorities with respect to the
development, manufacture or sale of the NMR Subsystem or Magnus Analyzer and will provide a copy of, or access to, such records to the other Party upon the reasonable request of the other Party. The Parties will seek to identify in a timely manner
the FDA records and documents requirements for both Parties and Third Parties to assist the Parties in meeting the document maintenance requirements herein. Each Party will provide the other Party with reasonable access to documents and other
materials that are useful in the regulatory filings and maintenance of Approvals in the Territory. 
 2.8 Manufacture-related
Activities. Varian acknowledges and agrees that, as developer and manufacturer of the NMR Subsystem, it must meet the quality standards of the FDA for OEM subsystem suppliers for medical devices and in connection therewith Varian agrees to
permit LipoScience, the System Developer, the System Manufacturer or applicable governmental regulatory authorities the right to inspect and audit Varian’s NMR manufacturing and other facilities and related records and operations, upon
reasonable notice, including without limitation, permitting a quality systems audit by LipoScience or a third party representative of LipoScience. LipoScience will be responsible for the all costs associated with such audit. LipoScience agrees to
promptly provide Varian with the written results of any such audit. Any information obtained by a Party during such visits will be treated as Confidential Information in accordance with Article 8 of this Agreement. 

2.9 Performance. Each Party will use it commercially reasonable efforts to develop the Magnus Analyzer, and its subsystems, and to
conduct all activities and responsibilities of such Party under this collaboration and assigned to it under the Development Plan and to cooperate with and provide reasonable support to the other Party in such other Party’s conduct of
activities, including cooperation and support for the related development activities of Third Parties. Each Party agrees to make its employees involved in the conduct of the development activities reasonably available upon reasonable advance notice
and during business hours at their respective places of employment to consult with the other Party on issues, including, but not limited to, regulatory, scientific, and technical issues arising under the Development Plan and in connection with any
request from any regulatory agency. Each Party will be responsible for its own costs and expenses associated with the development of the Magnus Analyzer, Varian Analyzer, NMR Subsystem, Autosampler and Control Subsystem and the performance of their
other obligations under this Agreement, including travel and related costs to attend meetings of the Oversight Committee as set forth in Section 2.3. 
 2.10 Visit of Facilities. Subject to the provisions of Article 8, each Party will permit the other Party or the representatives of the other Party to visit, upon reasonable notice and at reasonably
acceptable times, their respective facilities where the development activities are being conducted, and to consult informally, during such visits and by telephone, facsimile and email, with their respective personnel performing work on the
development activities. 

  
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 2.11 Subcontracts. It is understood and agreed by the Parties that either Party may
subcontract portions of the development of the Magnus Analyzer to a Third Party, including the System Developer and System Manufacturer; provided, however, that except as expressly set forth herein, neither Party may sublicense the rights in the
other Party’s intellectual property granted to such Party pursuant to Section 4.3 herein without the prior written consent of the other Party. 
 2.12 Records. The Parties will maintain records of the results of the development activities in sufficient detail and in good scientific manner appropriate for patent purposes and FDA filings and
as will properly reflect all work done and results achieved in the performance of the development activities pursuant to the Development Plan (including, but not limited to, all data in the form required to be maintained under any applicable
governmental regulations). 
 ARTICLE 3 COMMERCIALIZATION 

3.1 Commercialization in the LipoScience Field of Use. LipoScience will be the exclusive distributor of the Magnus Analyzer in the
Territory in the LipoScience Field of Use and will have the exclusive rights to make and have made (excluding the NMR Subsystem and components, parts and accessories therefor), use, market, distribute, sell and service (subject to the terms and
conditions of this Agreement and in the Supply Agreement), implement and use the Magnus Analyzer in the LipoScience Field of Use, including, but not limited to, the right to conduct marketing, reimbursement (e.g., seeking and maintaining pricing and
reimbursement approvals from Third Party payors), sales and distribution activities; provided, however, that LipoScience may subcontract with any Affiliate to perform any of the foregoing marketing, distribution, sales and service activities and any
Third Party to perform any of the foregoing marketing, distribution and sale activities. LipoScience will have the right to determine, in its sole discretion, the appropriate marketing and placement strategy for the Magnus Analyzer in the
LipoScience Field of Use. 
 3.2 Commercialization in the Varian Field of Use. Varian will be the exclusive distributor
of the Magnus Analyzer, Varian Analyzer and Autosampler in the Territory in the Varian Field of Use and will have the exclusive rights to make, have made, use, market, distribute, sell and service, implement and use the Magnus Analyzer, Varian
Analyzer and Autosampler in the Varian Field of Use, including, but not limited to, the right to conduct marketing, and sales and distribution activities and to subcontract with any Affiliate or Third Party to perform any of the foregoing
activities. Varian will have the right to determine, in its sole discretion, the appropriate marketing and placement strategy for the Magnus Analyzer, Varian Analyzer and Autosampler in the Varian Field of Use. 

3.3 Expenses. Each Party will be responsible for its own expenses and costs for any publicity, marketing or sales within such
Party’s Field of Use and as set forth in Sections 3.1 and 3.2 above. Upon the request of either Party, the other Party agrees to provide reasonable support to the marketing and sales efforts of the requesting Party; provided, however, that such
requesting Party will reimburse the other Party for actual expenses incurred by such other Party directly attributable to such support. 

  
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 3.4 Referrals. Each Party understands that, in the course of marketing the Magnus
Analyzer in such Party’s Field of Use, its employees or representatives may learn of sales and other business opportunities outside of such Party’s Field of Use. Accordingly, each Party agrees to forward to the other Party any such
requests or opportunities to the other Party and to provide the information regarding such opportunity to the other Party as such Party may have available. 
 3.5 Trademarks; Marking. Each Party shall have the right to create, develop and protect its own trademarks, service marks and branding for the sale and support of the Magnus Analyzer in its Field
of Use, including filing applications for the registration of such trademarks and services marks in the Territory as such Party may deem appropriate. Neither Party shall remove, obliterate or modify any trademarks, copyright notices, patent legends
or other intellectual property markings from the other Party’s Pre-Existing Technology or Developments. Each Party will mark its version of the Magnus Analyzer, and Varian will mark the Varian Analyzer, with the appropriate patent numbers or
other markings as required by or desirable under applicable law. 
 3.6 Branding. The Parties desire to establish and
preserve its trademarks and other branding for the Magnus Analyzer in its Field of Use, respectively. To that end, Varian agrees that when interacting with any customers of LipoScience, Varian will refer to the Magnus Analyzer and services by
LipoScience’s applicable trademarks and will identify itself as a LipoScience collaboration partner, and LipoScience agrees that when interacting with any customers of Varian, LipoScience will refer to the Magnus Analyzer, Varian Analyzer and
services by Varian’s applicable trademarks and will identify itself as a Varian collaboration partner. However, each Party will appropriately identify and credit the other Party in its sales and marketing of the Magnus Analyzer and Varian
Analyzer by prominent use of the phrases “Developed in Collaboration with LipoScience” for Varian sales, and “With Varian NMR Inside” for LipoScience sales, or as otherwise mutually agreed by the Parties. 

3.7 Purchase of NMR Subsystems. In consideration of (a) Varian’s investment in the development of the Magnus Analyzer, and
(b) licenses granted to LipoScience in Article 4, LipoScience shall (i) purchase all of its requirements for NMR Subsystems (including variations, derivatives and components therefor) and related hardware, software, components, parts, accessories,
support and service exclusively from Varian, and (ii) not license the LipoScience Diagnostic Applications to any Third Party for use with NMR Technology not supplied by Varian; provided, however, prior to the receipt of FDA Approval for the Magnus
Analyzer in the LipoScience Field of Use, LipoScience may license the LipoScience Diagnostic Applications to any Third Party provided such Third Party is not a direct or indirect manufacturer or provider of NMR Technology. In the event that
LipoScience licenses the LipoScience Diagnostic Applications to any Third Party as permitted herein, LipoScience shall promptly notify Varian, in writing, but in no event later than five days after the execution of any such licensing agreement,
subject to LipoScience’s confidentiality obligations to such Third Party. Notwithstanding the foregoing, the Parties acknowledge and 

  
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agree that LipoScience currently utilizes certain NMR analyzers and NMR Technology from [***] in its laboratory, testing and research operations (the [***]) and that LipoScience will have the
unlimited right to continue to utilize or transfer the [***] as it deems appropriate, to enhance, improve, maintain the [***], and to have the [***] serviced and maintained by [***]. 

3.7.1 Exclusivity by Varian. In consideration of (a) LipoScience’s investment in the development of the Magnus
Analyzer, (b) LipoScience’s commitment to purchase exclusively for Varian all of its requirements for NMR Subsystems (including versions, derivatives and components therefor) and related hardware, software, parts, accessories, support and
service and (c) the licenses granted to Varian in Article 4, Varian agrees that, during the Term, it will not directly or indirectly (i) sell NMR Subsystems (including variations, derivatives and components therefor) or related hardware, software,
components, parts, accessories, support and service, or (ii) license Varian Collaboration IP, in either case to any Third Party for use in LipoScience’s Field of Use; provided, however, that the foregoing shall not include (a) any magnet sold
stand-alone (i.e., not sold as part of, or to be incorporated into, an NMR system sold by Varian), or (b) any [***] to the extent that [***] is [***] under a [***] as of [***] to supply [***], or [***] or otherwise [***] or [***] the [***] of,
that [***] to a [***] or enter into a [***] of [***], or (c) [***] for [***]. 
 3.8 LipoScience Support.
LipoScience will provide product support to Varian for the portions of the Magnus Analyzer or Varian Analyzer supplied by LipoScience, including but not limited to offering for sale to Varian and its Affiliates all hardware and software upgrades,
performance improvements, and additional operational features, for Term and for five (5) years beyond the Term. Varian reserves the right not to implement such changes or upgrades. The Parties agree to negotiate the terms of such ongoing product
support in good faith and upon commercially reasonable terms taking into account the terms offer by LipoScience to other similarly-situated customers. 
 ARTICLE 4 INTELLECTUAL PROPERTY RIGHTS; 
 GRANT OF LICENSES

 4.1 Pre-Existing Technology. Each Party shall retain ownership of its own Pre-existing Technology, subject to the
licenses granted herein. 
 4.2 Collaboration Developments. 

4.2.1. Varian Developments. Subject to the grants of license herein, Varian will be the sole owner of any and all
inventions, technology, ideas, designs, methods, Patent Rights, copyrights and other intellectual property, whether or not patentable or protectable by copyright, developed or acquired by Varian, or its Affiliates, in the performance, or during the
Term, of this Agreement, other than Joint Developments (as defined below) (the “Varian Developments”); provided, however, that Varian Developments shall not include any Varian Diagnostic Applications. 

4.2.2. LipoScience Developments. Subject to the grants of license herein, LipoScience will be the sole owner of any
and all inventions, technology, ideas, designs, 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 12 

 
methods, Patent Rights, copyrights and other intellectual property, whether or not patentable or protectable by copyright, developed or acquired by LipoScience, or its Affiliates, in the
performance, or during the Term, of this Agreement other than Joint Developments (as defined below) (“LipoScience Developments”); provided, however, that LipoScience Developments shall not include any LipoScience Diagnostic Applications.

 4.2.3 Joint Developments. With respect to any inventions, technology, ideas, designs, methods, Patent
Rights, copyrights or other intellectual property that are jointly developed by the Parties, or developed by the Systems Developer and/or Systems Manufacturer, whether solely or jointly with either Party (where joint development is as determined
under the patent and other intellectual property laws of the United States) (“Joint Developments”), the Parties hereby agree that Varian will be the sole owner of all Joint Developments which relate directly to the Varian Pre-Existing
Technology, and LipoScience hereby agrees to assign, and hereby does assign, all rights, title and interest in and to such Joint Developments to Varian, subject to the grants of license herein. The Parties further agree that all Joint Developments
which relate directly to the LipoScience Pre-Existing Technology shall be solely owned by LipoScience, and Varian hereby agrees to assign, and hereby does assign, all rights, title and interest in and to such Joint Developments to LipoScience,
subject to the grants of license herein. The Systems Developer and Systems Manufacturer shall also be required to agree to the foregoing assignments of ownership to Varian and LipoScience with respect to all intellectual property developed by them,
whether solely or jointly, pursuant to their agreements with LipoScience. All remaining Joint Developments that are not assigned to either Varian or LipoScience shall be jointly owned by the Parties (the “Jointly-Owned Developments”),
subject to the grants of license herein. Notwithstanding the foregoing, the Parties acknowledge and agree that (a) the [***], as well as that portion of the [***] necessary to [***] the [***], is a [***] and (b) all [***] which relate
directly to [***] (including the [***],[***],[***] and other [***],[***],[***] and [***]) shall be considered to directly relate only to [***] and shall be [***] to [***]. 

4.2.3. Disclosure. Each Party will promptly disclose to the other Party any invention, idea, designs, methods,
technology, copyrights or other intellectual property (whether or not patentable or protectable by copyrights) relating to the Magnus Analyzer (including the Autosampler, the NMR Subsystem and the Control Subsystem) conceived, developed, created or
acquired (subject to any Third Party confidentiality obligations existing as of the Effective Date) by such Party during the Term. 
 4.3 Licenses. 
 4.3.1. Grant of License by Varian.
Subject to the terms and conditions of this Agreement, Varian hereby grants to LipoScience an exclusive, royalty-free, worldwide license (including the right to grant sublicenses only to the System Developer and the 

 
 [***] = Certain information on this page, marked by brackets,
has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  
 13 

 
System Manufacturer(s)) in and to the Varian Collaboration IP as may be required or useful for the collaboration, development and manufacture (including have manufactured) of the Magnus Analyzer
(but excluding the NMR Subsystem and components, parts and accessories therefor), such exclusivity being subject to Varian having the right to grant the foregoing license. Varian further grants to LipoScience an exclusive, royalty-free, worldwide
license in and to the Varian Collaboration IP to market, sell, distribute, export, service, support, implement and use (including in each case (but except for service) the right to have a Third Party undertake such acts on behalf of LipoScience) the
Varian Collaboration IP in connection with the Magnus Analyzer in the Territory in the LipoScience Field of Use, such exclusivity being subject to Varian having the right to grant the foregoing license. The term of the foregoing licenses shall be
the Term. 
 4.3.2. Grant of License by LipoScience. Subject to the terms and conditions of this
Agreement, LipoScience hereby grants to Varian an exclusive, royalty-free, worldwide license in and to the LipoScience Collaboration IP as may be required for the collaboration, development and manufacture (including have manufactured) of the Magnus
Analyzer and the Varian Analyzer, such exclusivity being subject to LipoScience having the right to grant the foregoing license. LipoScience further grants to Varian an exclusive, royalty-free, worldwide license in and to the LipoScience
Collaboration IP to market, sell, distribute, export, service, support, implement and use (including in each case the right to have a Third Party undertake such acts on behalf of Varian) the LipoScience Collaboration IP in connection with the Magnus
Analyzer and as may be required for the Varian Analyzer in the Territory in the Varian Field of Use, such exclusivity being subject to LipoScience having the right to grant the foregoing license. The term of the foregoing licenses shall be the Term.

 4.3.3. Cross-Licenses. Each Party hereby grants to the other Party an exclusive, royalty-free worldwide
license to its rights and interest in all Jointly-Owned Developments to market, sell, distribute, export, service, support, implement and use the Jointly-Owned Developments in the Territory in such other Party’s Field of Use. The term of the
foregoing license shall be the Term. Each Party reserves the right to practice and use such Jointly-Owned Developments in its own internal research and development operations, including in performance of this Agreement, but, for the Term, will not
market and sell such Jointly-Owned IP outside its own Field of Use. 
 4.3.4. Limitations on Licenses;
Reservation of Rights. Notwithstanding the licenses granted to LipoScience by Varian herein, LipoScience acknowledges and agrees that Varian has [***] (the [***]) pursuant to which Varian has [***] to [***] to [***] in and to [***], which may be
[***] within the [***] and that with respect to such [***], the [***] shall be [***]. Each Party reserves all rights in and to its Pre-Existing Technology, Patent Rights and Developments not expressly granted herein and each Party further reserves
the right to use, develop, modify, and enhance such Pre-Existing Technology, Patent Rights and Developments for its own internal research and development efforts, including the development of the Magnus Analyzer. 

 
 [***] = Certain information on this page, marked by brackets,
has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  
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 4.3.5. LipoScience Diagnostic Applications. Notwithstanding
Section 4.3.2, LipoScience shall retain all right, title and interest in and to LipoScience Diagnostic Applications, including without limitation, the NMR LipoProfile, and Varian will not acquire any right or license in and to such LipoScience
Diagnostic Applications under this Agreement. 
 4.3.6. Varian Diagnostic Applications. Notwithstanding
Section 4.3.1, Varian shall retain all right, title and interest in and to Varian Diagnostic Applications. In the case of any Varian Diagnostic Applications during the Term, the Parties agree that they will negotiate in good faith a license
agreement under which Varian will grant, subject to any Third Party limitations, to LipoScience the exclusive right to reproduce, use, modify, support, sell, market and distribute such Diagnostic Applications in LipoScience’s Field of Use, and
LipoScience will support, sell, market and distribute such Varian Diagnostic Applications in LipoScience’s Field of Use; such license will be upon commercially reasonable terms and conditions, including without limitation, pricing or royalty
terms which reflect the contributions of each Party. 
 4.4 Section 365(n) of the Bankruptcy Code. All rights and
licenses granted under or pursuant to any section of this Agreement are, and shall otherwise be deemed to be, for purposes of Section 365(n) of the Bankruptcy Code, licenses of rights to “intellectual property” as defined under
Section 101(35A) of the Bankruptcy Code. The Parties shall retain and may fully exercise all of their respective rights and elections under the Bankruptcy Code. Upon the bankruptcy of any Party, the non-bankrupt Party shall further be entitled
to a complete duplicate of (or complete access to, as appropriate) any such intellectual property, and such, if not already in its possession, shall be promptly delivered to the non-bankrupt Party, unless the bankrupt Party elects to continue, and
continues, to perform all of its obligations under this Agreement. 
 ARTICLE 5 VARIAN INKIND CONTRIBUTIONS 

5.1 Collaboration Costs. Each Party will be responsible for its own costs associated with performance of this Agreement, except as
expressly set forth herein. It is anticipated that the financial benefits of the collaboration will be realized by each Party through sales of the Magnus Analyzer and increased demand for and sales of the NMR Subsystem and LipoScience Diagnostic
Applications. 
 5.2 In-Kind Contributions. 

5.2.1. Development Contributions. Varian agrees that it will dedicate certain employees of Varian to the
development of the Probe for integration in the NMR Subsystem, such development may be performed jointly with employees or representatives of LipoScience. The Parties will mutually agree on the technical and 

  
 15 

 
functional requirements and specifications of the Probe and perform related development activities as agreed by the Parties and as set forth in the Development Plan. Each Party will be
responsible for its own costs associated with the development of the Probe. 
 5.2.2. Equipment. Varian
agrees to provide the following “Units” to LipoScience upon the terms below and at no cost to LipoScience until title to the Units is transferred to LipoScience, except as expressly set forth below with respect to Units [***]: 

Unit 1: Varian will consign a Varian NMR “Nirvana” console to LipoScience 

 

	 	•	 	 Promptly following the Effective Date, Varian will deliver and install a Nirvana console on LipoScience’s existing Varian NMR Mercury system at
the LipoScience facilities 

  

	 	•	 	 Varian will provide all ordinary system service for the Nirvana console while on consignment 

 

	 	•	 	 Varian will transfer title of Nirvana console of Unit 1 to LipoScience at the end of the Magnus Analyzer development as defined in the Development Plan

 Unit 2: Varian will consign a Varian NMR Nirvana system (i.e., including actively shielded magnet) to
LipoScience 
  

	 	•	 	 Promptly following the appointment of the System Developer and System Manufacturer and as agreed upon in executed agreements with the System Developer
and System Manufacturer, Varian will deliver and install the Nirvana system at either the Systems Developer or System Manufacturer 

  

	 	•	 	 Varian will provide all ordinary service for the Nirvana system while held by System Developer or System Manufacturer 

 

	 	•	 	 Upon development of the Magnus Analyzer Console, Varian will consign and install the Magnus Analyzer Console on Unit 2 (and take back the Nirvana
console) 

  

	 	•	 	 When the Magnus Analyzer development is completed, Unit 2 will be moved to System Manufacturer (which will hold system for testing and development
purposes as long as it is the System Manufacturer) 

 Unit 3: Varian will consign an NMR Subsystem for the
Magnus Analyzer prototype to LipoScience 
  

	 	•	 	 Varian will deliver Unit 3 in accordance with the Development Plan 

 

	 	•	 	 Varian will provide all ordinary service for Unit 3 while on consignment 

 

	 	•	 	 When the Magnus Analyzer development is completed and production commences, Varian will transfer title to Unit 3 to LipoScience

  
 [***] = Certain information on
this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential
treatment has been requested with respect to the omitted portions. 

  
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 Unit 4: Varian will consign an NMR Subsystem for the Magnus Analyzer prototype to
LipoScience 
  

	 	•	 	 Varian will deliver Unit 4 in accordance with the Development Plan 

 

	 	•	 	 Varian will provide all ordinary service for Unit 4 while on consignment 

 

	 	•	 	 When Magnus Analyzer development is completed and production commences, Unit 4 will be returned to Varian (with sample handling system included, at
Varian’s expense), which Varian will then own and use for its own development and marketing purposes 

Units [***]: Varian will sell fully developed NMR Subsystems for Magnus Analyzer to LipoScience at a [***] whatever going forward sales
price is negotiated between the parties pursuant to Supply Agreement. Varian will ship Units [***] to the System Developer or Manufacturer on the dates requested by LipoScience. 

 

	 	•	 	 LipoScience may defer payment to Varian on these initial [***] units [***] until earlier of [***] from the Effective Date or the date of FDA approval
of the Magnus Analyzer 

 While any of the Units are under consignment to LipoScience, the System Developer or System
Manufacturer and in their possession, LipoScience will ensure that it has adequate insurance to cover the risk of loss to such Units. After LipoScience takes title to Units 1 and 3 above, the terms set forth in the Supply Agreement for Varian’s
support and service shall apply. 
 ARTICLE 6 SUPPLY AGREEMENT 

6.1 Parties’ Intent. The Parties will enter into the Supply Agreement, in accordance with the specified milestone in the
Development Plan, pursuant to which Varian will sell to LipoScience and LipoScience will purchase exclusively from Varian NMR Subsystems and related hardware, software, components, parts, accessories, support and service for the Magnus Analyzer on
terms that will be commercially reasonable and negotiated in good faith between the Parties. 
 6.2 Pricing. The Parties
agree that the purchase price to LipoScience of the NMR Subsystems to be incorporated into the Magnus Analyzer cannot yet be determined with certainty; provided, however, that upon completion of the development of the Magnus Analyzer, the Parties
agree to negotiate in good faith the purchase price to LipoScience for such NMR Subsystems. The Parties further agree that unless there are substantial new requirements or features in the commercial version of the NMR Subsystem that have an impact
upon production costs of the NMR Subsystem, the initial pricing will be [***] the [***] provided by Varian [***]. The parties will negotiate in good faith provisions allowing for price increases (such as to account for cost increases from new
requirements or features, enhancements, Third Party royalties, or cost increases beyond the parties’ reasonable control, such as supplier price increases or inflation) or for price decreases (such as to account for volume discounts or where

  
 [***] = Certain information on this page, marked
by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  
 17 

 
the parties are able to bring efficiencies to bear). Other terms of supply and support (such as delivery terms, payment terms, warranties, after warranty service, field service, etc.) will be
commercially reasonable and negotiated in good faith between the Parties, taking into account the original intent of the Parties in entering into the collaboration, the terms offered by Varian to other similarly-situated customers of NMR systems and
the agreed purchase price to be paid by LipoScience for the NMR Subsystems. 
 6.3 Varian Support. Pursuant to the terms
and conditions of the Supply Agreement, Varian will provide product support for the NMR Subsystems, including but not limited to offering for sale to LipoScience and its Affiliates all hardware and software upgrades, performance improvements, and
additional operational features, for Term and for [***] beyond the Term. LipoScience reserves the right not to implement such changes or upgrades. 
 6.4 Default. Pursuant to the terms and conditions of the Supply Agreement, LipoScience will have the right to secure Third Party alternative sources for the NMR Subsystem in the event of a material
default by Varian in its delivery, support commitments, FDA or other regulatory requirement or other terms of the Supply Agreement, provided such Third Party shall have no right to use, and LipoScience shall not disclose, any Varian Collaboration IP
(except for the Jointly-Owned Developments); and provided, however, that if requested by LipoScience, Varian will continue to supply the NMR Subsystem to LipoScience as set forth in Section 11.3. 

6.5 Customer Support. LipoScience will have the responsibility for providing first tier customer support to its customers in the
LipoScience Field of Use for the Magnus Analyzer, including the NMR Subsystem incorporated therein, including providing telephone support. Such support will be provided pursuant to agreements entered into by LipoScience and its customers. Varian
agrees to provide second tier telephone support for the customers of LipoScience in the LipoScience Field of Use; Varian will supply such support either to the LipoScience support personnel or, at the option of LipoScience, directly to the
LipoScience customer. LipoScience agrees to use its commercially reasonable efforts to address customer support issues prior to requesting assistance from Varian. Varian agrees that this second tier support shall be provided by Varian at no
additional cost to LipoScience or its customers. 
 6.6 Field Service. LipoScience will provide routine maintenance and
service, either directly or through an Affiliate, to its customers for the Magnus Analyzer, including the NMR Subsystem, including on site maintenance and repair. Varian agrees to provide assistance to LipoScience personnel via telephone to assist
such personnel in providing services relating to the NMR Subsystem to LipoScience customers. If, after using commercially reasonable efforts, LipoScience is unable to provide such repair or other maintenance services for a customer, Varian agrees
that it will provide Varian service personnel to LipoScience for on site customer repair issues within twenty-four (24) hours of request from LipoScience. Varian will provide the pricing and other terms of such Varian support and personnel in
the Supply Agreement. 
  
 [***] = Certain information
on this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission.
Confidential treatment has been requested with respect to the omitted portions. 

  
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 6.7 Training. Subject to mutually agreed upon limits on the total man-hours of
training to be provided at no additional cost to LipoScience, Varian will provide training to LipoScience personnel to enable LipoScience to provide routine periodic customer and field support in the LipoScience Field of Use as described in Sections
6.5 and 6.6 above and to enable LipoScience to provide operational training to its customers on the use of the NMR Subsystem. Such training will take place at mutually agreed upon times and at mutually agreed on locations. 

ARTICLE 7 PATENTS 
 7.1 Patent Rights. 
 7.1.1. Varian Patent Rights; LipoScience
Patent Rights. Each Party shall retain sole responsibility for and control over the preparation, filing, prosecution and maintenance of such Party’s Patent Rights and other intellectual property protection; provided, however, that the
Parties agree to consult with each other regarding the appropriateness of seeking patent protection for any inventions or improvements relating to the Magnus Analyzer or NMR Subsystem, including the jurisdictions in which such Patent Rights should
be sought. Neither Party shall abandon prosecution or maintenance of any Patent Rights for Varian Developments, LipoScience Development or assigned Joint Developments, respectively, without notifying the other Party in a timely manner of its
intention and reason therefore and providing such other Party with reasonable opportunity to comment upon such abandonment and, with respect to such Varian Developments, LipoScience Developments and assigned Joint Developments only, to assume
ownership and responsibility for prosecution or maintenance (including both costs therefor) of such Patent Rights. Each Party agrees to discuss in good faith whether or not to file patent applications in the United States or other countries with
respect to such Varian Developments, LipoScience Developments and assigned Joint Developments and to give due consideration to the other Party’s comments. 
 7.1.2. Jointly-Owned Developments. The Parties shall mutually determine whether or not to file patent applications in the United States or other countries with respect to Jointly-Owned
Developments, taking into consideration the sales and marketing plans of each Party. Each Party will have an undivided ownership interest in such jointly-filed patent applications and such applications will be prepared and prosecuted by mutually
agreed upon counsel. The Parties shall each have the opportunity to review and comment upon all applications and official correspondence relating thereto and shall share equally in the associated costs. If the Parties cannot agree on whether to seek
patent protection in any country, then the Party wishing to seek such protection may file and prosecute any such patent applications and such Party shall be the sole owner of record and responsible for all the costs of such patent application and
the non-filing Party shall assign all its right, title and interest in and to the invention claimed in the patent issuing from such application. 

  
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 7.2 Infringement 

7.2.1. Notification. Each party shall promptly report in writing to the other Party during the Term of this
Agreement any known infringement or suspected infringement relating to the Magnus Analyzer, Varian Analyzer, Autosampler or of such other Party’s Patent Rights and shall provide the other Party with all available evidence supporting said
infringement or suspected infringement. 
 7.2.2. Prosecution. Each Party shall have the right, but not
the obligation, to initiate or prosecute an infringement or other appropriate suit or action against any Third Party who at any time has infringed or is suspected of infringing (an “Infringer”) any of the Patent Rights in its Field of Use.
Each party shall give the other Party sufficient advance notice of its intent to file said suit and the reasons therefore, and shall provide such other Party with an opportunity to make suggestions and comments regarding such filing. The Parties
will keep each other reasonably informed of the status and progress of any such litigation. In the event the Infringer’s acts affect both Parties’ Fields of Use or affects a Party’s Field of Use under the other Party’s Patent
Rights, the Parties may proceed together in bring a suit, or a Party may choose to prosecute the suit alone if the other Party is unwilling to join. Upon request of the prosecuting Party, the other Party shall join as a party to the suit against
such Infringer if the participation of other Party is necessary to maintain the suit. In any event, the other Party shall offer reasonable assistance to the prosecuting Party in connection therewith. Neither Party shall settle any such action or
otherwise consent to an adverse judgment in any such action that materially adversely affects the rights or interests of the other Party under this Agreement, including, without limitation, issues of validity of any Patent Rights, without the prior
written consent of the other Party. 
 7.2.3. Selecting Counsel, Costs and Recovery. If the Parties agree
to bring the suit together, the Parties shall mutually agree on the selection of counsel and shall pay equal shares of all fees and costs. Alternatively, if a Party is unwilling to join in the suit, the prosecuting Party shall have the sole and
exclusive right to select counsel for any such suit and action and shall pay all expenses of the suit, including, but not limited to, attorneys’ fees and court costs. Any damages, royalties, settlement fees, recovery or other consideration for
infringement resulting from a suit shall be distributed as follows: (i) equally between the Parties if the Parties brought suit together; or (ii) entirely to the prosecuting Party when the other Party is unwilling to initiate or join in a
suit. 
 7.2.4. Notification of Third Party Claim. Each Party shall promptly report in writing to the
other Party during the Term any claim or allegation by any Third Party that the development or commercialization of the Magnus Analyzer infringes the intellectual property rights of any Third Party and shall provide the other Party with all
available evidence supporting said infringement or suspected infringement. If the claim or allegation relates primarily to the NMR Subsystem as incorporated in the Magnus 

 

  
 20 

 
Analyzer, Varian shall have the primary obligation to defend any such suit or action and if the claim or allegation relates primarily to the portions of the Magnus Analyzer developed or provided
by LipoScience (and does not directly implicate the NMR Subsystem), LipoScience shall have the primary obligation to defend any such suit or action; provided, however, that the costs of such defense, including any amounts payable to the Third Party
in settlement or judgement, will be shared equally by the Parties unless and to the extent a claim or allegation relates solely to the Varian Pre-Existing Technology or the LipoScience Pre-Existing Technology or to Varian’s or
LipoScience’s negligence, willful misconduct or reckless act or omission, in which Varian or LipoScience, respectively, shall reimburse the other Party for costs related to such defense and shall be fully responsible for any settlement or
judgment. Notwithstanding the foregoing, LipoScience shall be fully responsible for and shall indemnify and hold Varian harmless for all infringement claims to the extent such claims relate to the LipoScience Diagnostic Application. 

ARTICLE 8 CONFIDENTIALITY 
 8.1 Confidentiality. Except as otherwise provided in this Article 8, each Party shall maintain Confidential Information of the other Party in confidence and shall not disclose Confidential
Information of the other Party to any Third Party and shall not use Confidential Information of the other Party except as expressly authorized under this Agreement. “Confidential Information” shall mean any and all proprietary information
(whether in written, electronic, visual, verbal or other form) received from the other Party or its representatives, including, but not limited to, all proprietary information relating to any technology, product, method, process or intellectual
property of such disclosing Party (including, but not limited to, Patent Rights, and other owned or licensed intellectual property rights, data, know-how, samples, technical and non-technical materials and specifications), as well as any business
plan, financial information, research data or results, or other confidential commercial information of or about such disclosing Party that have been identified or labeled as being “confidential”; provided, however, that Confidential
Information shall not include any information that: (a) is or becomes part of the public domain other than by unauthorized acts or omissions of the Party obligated not to disclose such Confidential Information or its employees, directors,
officers, or agents (collectively, the “Receiving Party”); (b) can be shown by written documents to have been disclosed to the Receiving Party by a Third Party; provided, however, that such Third Party had no obligation of
confidentiality or non-use to the disclosing Party with respect to such Confidential Information; (c) can be shown by written documents to have been in the possession of the Receiving Party prior to disclosure by the disclosing Party; provided,
however, that such Confidential Information was not obtained directly or indirectly from the disclosing Party prior to this Agreement pursuant to a separate confidentiality agreement; or (d) is required to be disclosed by the Receiving Party by
a court or governmental agency or otherwise pursuant to law; provided, however, that in connection with this clause (d) the Receiving Party shall notify the other Party immediately upon receipt thereof and give such other Party sufficient
advance notice to permit it to seek a protective order or other similar order with respect to such Confidential Information; and 

  
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provided, further, that the Receiving Party furnishes only that portion of the Confidential Information that it is advised by counsel is legally required whether or not a protective order or
other similar order is obtained by the other Party. 
 8.2 Disclosure. To the extent that it is reasonably necessary, a
Party may disclose Confidential Information it is otherwise obligated under this Article 8 not to disclose to its employees on a need-to-know basis and on condition that such employees have agreed in writing to non-use and non-disclosure obligations
essentially the same as those set forth herein and to keep the Confidential Information confidential to the same extent as such Party is required to keep the Confidential Information confidential. In addition, a Party may disclose such Confidential
Information: (a) to government or other regulatory authorities to the extent that such disclosure is required by law, regulation or order (i) in connection with the filing, prosecution or maintenance of patents for which the Party
disclosing the Confidential Information has responsibility or is permitted under this Agreement to file, prosecute and maintain, or (ii) to obtain Approval; (b) in confidence, to lawyers, accountants and sources of funding of a Party and
(d) to sublicensees or subcontractors, as permitted herein, in connection with any sublicense of the technology or intellectual property, or portion thereof, licensed hereunder as permitted under this Agreement. In addition, a Party may
disclose the terms of this Agreement to any investors or potential investors, lenders, and other potential financing sources, or to a Third Party in connection with a merger or acquisition or proposed merger or acquisition or a license or proposed
license of the technology or intellectual property licensed hereunder, and to Affiliates, attorneys, accountants, stockholders, investment bankers, advisers or other consultants of the foregoing, in each case provided that the Person to which such
disclosure is made is obligated by written agreement to keep such information confidential on essentially the same terms as set forth herein and to use such Confidential Information solely to evaluate such investment, financing, acquisition, merger
or license. 
 ARTICLE 9 REPRESENTATIONS AND WARRANTIES 

9.1 Representations and Warranties of LipoScience. LipoScience represents and warrants as of the Effective Date that: 

(a) LipoScience is a corporation duly organized, validly existing and in corporate good standing under the laws of Delaware and is duly
qualified and authorized to transact business, and is in good standing as a foreign corporation, in each jurisdiction where such qualification is necessary; 
 (b) LipoScience has the legal right, authority and power to enter into this Agreement, and to extend the rights and licenses granted to Varian in this Agreement; 

(c) LipoScience has taken all necessary action to authorize the execution, delivery and performance of this Agreement; 

  
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 (d) upon the execution and delivery of this Agreement, this Agreement shall constitute a
valid and binding obligation of LipoScience enforceable in accordance with its terms, except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ and contracting
parties’ rights generally and except as enforceability may be subject to general principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law); 

(e) the performance of its obligations under this Agreement will not conflict with its charter documents or result in a breach of any
agreements, contracts or other arrangements to which it is a party; 
 (f) LipoScience is the sole and exclusive owner or the
licensee of LipoScience Pre-Existing Technology, except for the [***] and [***]; 
 (g) LipoScience has received no written
claim threatening or asserting that the practice of the LipoScience Pre-Existing Technology infringes the Patent Rights of any Third Party; 
 9.2 Representations and Warranties of Varian. Varian represents and warrants as of the Effective Date that: 
 (a) Varian is a corporation duly organized, validly existing and in corporate good standing under the laws of Delaware and is duly qualified and authorized to transact business, and is in good standing as
a foreign corporation, in each jurisdiction where such qualification is necessary; 
 (b) Varian has the legal right, authority
and power to enter into this Agreement, and to extend the rights and licenses granted to LipoScience in this Agreement; 
 (c)
Varian has taken all necessary action to authorize the execution, delivery and performance of this Agreement; 
 (d) upon the
execution and delivery of this Agreement, this Agreement shall constitute a valid and binding obligation of Varian enforceable in accordance with its terms, except as enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium or similar laws, affecting creditors’ and contracting parties’ rights generally and except as enforceability maybe subject to general principles of equity (regardless of whether such enforceability is considered
in a proceeding in equity or at law); 
 (e) the performance of its obligations under this Agreement will not conflict with
Varian’s charter documents or result in a breach of any agreements, contracts or other arrangements to which it is a party; and 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 23 

 (f) to the best of the knowledge of Varian, subject to the grants of license therein, Varian
is the sole and exclusive owner or the licensee of the Varian Pre-Existing Technology, except for the [***] and the [***]; 

(g) Varian has received no written claim threatening or asserting that the practice of the Varian Pre-Existing Technology infringes the
Patent Rights of any Third Party; 
 (h) Varian’s obligations under existing licenses do not, and will not, require Varian
to provide any Third Party with access to, copies of or any rights in or to the LipoScience Collaboration IP, except for Jointly-Owned Developments. 
 9.3 Warranty Disclaimer. EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN THIS AGREEMENT, NEITHER PARTY MAKES ANY WARRANTY WITH RESPECT TO THE LIPSCIENCE COLLABORATION IP OR VARIAN COLLABORATION IP, THE
NMR SUBSYSTEM, THE MAGNUS ANALYZER OR OTHER SUBJECT MATTER OF THIS AGREEMENT AND HEREBY DISCLAIMS WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, VALIDITY, SCOPE AND NON-INFRINGEMENT WITH RESPECT TO ANY AND ALL OF THE FOREGOING.

 9.4 Limited Liability. EXCEPT FOR THEIR RESPECTIVE OBLIGATIONS UNDER ARTICLE 8 or ARTICLE 10 or SECTION 7.2, NEITHER
PARTY WILL BE LIABLE THEORY FOR ANY PUNITIVE, EXEMPLARY, INCIDENTAL, INDIRECT OR CONSEQUENTIAL DAMAGES OR LOST PROFITS WITH RESPECT TO ANY SUBJECT MATTER OF THIS AGREEMENT UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER LEGAL OR EQUITABLE.

 ARTICLE 10 INDEMNITY 
 10.1 Cross Indemnity. Each Party (the “Indemnifying Party”) agrees to defend, indemnify and hold the other Party, its Affiliates and their respective directors, officers, employees
and agents and their respective heirs and assigns (the “Indemnified Party”) harmless from all Third Party claims, actions, losses, damages, liabilities or expenses (including, but not limited to, reasonable attorneys’ fees)
(each, a “Loss”) arising as a result of a breach by the Indemnifying Party of any of its representations or warranties under this Agreement. 
 10.2 Procedure. If an Indemnified Party intends to claim indemnification under this Article 10, the Indemnified Party shall notify the Indemnifying Party of any Loss in respect of which the
Indemnified Party intends to claim such indemnification, and the Indemnifying Party shall assume the defense thereof with counsel mutually satisfactory to the Parties. The Indemnified Party shall provide reasonable assistance to the Indemnifying
Party and its legal representatives, at the Indemnifying Party’s expense, in the investigation of any action, claim or liability covered by this indemnification. The Indemnifying Party shall not, without the written consent of Indemnified
Party, settle or compromise any Loss or consent to the entry of any judgment with respect to any Loss (a) that does not release Indemnified Party from all liability 

 
 [***] = Certain information on this page, marked by brackets,
has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  
 24 

 
with respect to such Loss or (b) which may materially adversely affect Indemnified Party or under which Indemnified Party would incur any obligation or liability, other than one as to which
Indemnifying Party has an indemnity obligation hereunder. 
 ARTICLE 11 TERM AND TERMINATION 

11.1 Term. If not earlier terminated as provided in this Article 10, the term of this Agreement (the “Term”)
shall commence on the Effective Date and expire seven (7) years after FDA Approvals are obtained for the marketing and sale of the Magnus Analyzer in the United States; provided, however, that this Agreement may be renewed for subsequent five (5)
year terms upon mutual agreement of the Parties. If either Party determines that it does not intend to renew the Agreement for an additional term, such Party shall provide [***] written notice to the other Party of its intent not to renew the
Agreement at the end of the initial seven year term or any subsequent five year term. 
 11.2 Termination. 

11.2.1. Voluntary. The Parties may terminate this Agreement at any time upon written agreement. 

11.2.2. Default by Either Party. Either Party may terminate this Agreement by notification, in writing, ninety
(90) days prior to termination (i) upon the occurrence of a breach of a material term of this Agreement, including the failure of such Party to meet any milestones or other requirements of the Development Plan as set forth therein, if the
breaching Party fails to demonstrate its ability to remedy such breach within thirty (30) days after notice thereof by the non-breaching Party or, with respect to a breach (other than a failure to make a payment) that cannot be cured within
such period, then such longer period (up to 90 days) as may be reasonably necessary, using commercially reasonable efforts, to cure the breach, or (ii) if the other Party files for protection under the bankruptcy laws, makes an assignment for
the benefit of creditors, appoints or suffers appointment of a receiver or trustee over its property, files a petition under any bankruptcy or insolvency act or has any such petition filed against it and such proceeding remains undismissed or
unstayed for a period of more than thirty days. 
 11.3 Effect of Expiration or Termination of the Agreement. Except as
expressly provided herein, the expiration or termination of this Agreement shall not relieve the Parties of any obligation accruing prior to such expiration or termination and all rights and licenses granted under this Agreement shall be terminated.
Further, upon the termination or expiration of this Agreement, each Party agrees to negotiate in good faith to license the rights to its Pre-Existing Technology and Developments to the other Party for use in such other Party’s Field of Use.

 If for any reason Varian elects to terminate this Agreement, other than due to a material breach by LipoScience, but
including non-renewal of the Term, or if LipoScience terminates this Agreement due to a material breach by Varian, Varian agrees to sell to LipoScience and its Affiliates, the NMR Subsystem as then incorporated in the Magnus Analyzer until:
(a) such time as either LipoScience has 
  
 [***]
= Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 25 

 
developed, received necessary Approvals for and commenced marketing of a replacement or successor to the Magnus Analyzer which does not incorporate or require the NMR subsystem, or (b) the
period of two (2) years from the effective date of expiration of the Term (provided that Varian has provided the [***] as required), or (c) three years from the effective date of a termination by LipoScience due to uncured breach by
Varian, whichever of (a) or (b) or (c) is shorter. 
 In addition, if for any reason, LipoScience chooses to
terminate this Agreement, including non-renewal of the Term, or if Varian terminates this Agreement due to a material breach by LipoScience, LipoScience agrees to make available to Varian those portions or parts of the Magnus Analyzer, Varian
Analyzer or Autosampler supplied by LipoScience as then incorporated in the Varian-version of the Magnus Analyzer, Varian Analyzer or Autosampler until: (a) such time as either Varian has developed, received necessary Approvals for and
commenced marketing of a replacement or successor to the Varian-version of the Magnus Analyzer, Varian Analyzer or Autosampler which does not incorporate or require the portions or part of the Magnus Analyzer, Varian Analyzer or Autosampler supplied
by LipoScience, or (b) the period of two (2)years from the effective date of expiration of the Term (provided that LipoScience has provided the [***] as required), or (c) three years from the effective date of termination by Varian due to
uncured breach by LipoScience, whichever of (a) or (b) or (c) is shorter. 
 11.4 Survival of Provisions Upon
Expiration or Termination. The provisions of Articles 7, 8 and 10, and Sections 2.7 and 2.12 (as these sections relate to access to and maintenance of documents and information), 4.2.1, 4.2.2, 4.2.3, 9.3, 9.4, 11.3, 11.4, 12.5 and 12.7 shall
survive the expiration or termination of this Agreement for any reason. 
 ARTICLE 12 MISCELLANEOUS 

12.1 Press Release and Announcements. Neither Party shall issue any press release or public announcement relating to the subject
matter of this Agreement without the prior written approval of the other Party; provided, however, that either Party may make any public disclosure it reasonably believes is necessary under applicable law or stock market rule (in which case
the disclosing Party shall use reasonable efforts to advise the other Party and provide it with a copy of the proposed disclosure prior to making such disclosure). 
 12.2 Assignment. This Agreement may not be assigned or otherwise transferred by either Party without the prior written consent of the other Party; provided, however, that (a) LipoScience may,
without such consent from Varian, assign its rights together with its obligations under this Agreement in connection with the sale of all or substantially all of its assets or business, and (b) Varian may, without consent from LipoScience,
assign its rights together with its obligations under this Agreement in connection with the sale of all or substantially of its NMR business; provided, however, that such Party’s rights and obligations under this Agreement shall be assumed by
its successor in interest in any such transaction. Any purported assignment in violation of the preceding sentence shall be void. Any permitted assignee shall assume all obligations of its assignor under this Agreement. 

12.3 Severability. If any term, covenant or condition of this Agreement shall be held to be invalid or unenforceable under
applicable law, then (a) the remainder of this Agreement shall not be affected and shall otherwise be valid and enforced to the fullest extent permitted by law, and (b) the Parties shall use their commercially reasonable efforts to replace
such void or 
  
 [***] = Certain information on this
page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential
treatment has been requested with respect to the omitted portions. 

  
 26 

 
unenforceable provisions of this Agreement with a valid and enforceable provision that will achieve, to the greatest extend possible, the economic, business and other purposes of such void or
unenforceable provision. 
 12.4 Notices. Any consent, notice or report required or permitted to be given or made under
this Agreement by either of the Parties hereto to the other shall be in writing, delivered personally or by facsimile (and promptly confirmed by personal delivery or courier) or courier, postage prepaid (where applicable), addressed to such other
Party at its address indicated below, or to such other address as the addressee shall have last furnished in writing to the addressor and shall be effective upon receipt by the addressee. 

 

							
	 If to LipoScience:
	  	2500 Sumner Boulevard	  		  	
		  	Raleigh, NC 27616	  		  	
		  	Attn: Timothy J. Williams, Esq.	  		  	
		  	Fax: [***]	  		  	
		  	Email: [***]	  		  	

  
 [***] = Certain information on
this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential
treatment has been requested with respect to the omitted portions. 

  
 27 

							
	 With a copy to:
	 	Hutchison + Mason PLLC	 		  	
		 	3110 Edwards Mill Road, Suite 100	 		  	
		 	Raleigh, NC 27612	 		  	
		 	Attention: Holly A. Coldiron	 		  	
		 	Fax: [***]	 		  	
		 	Email: [***]	 		  	
		 		 		  	
	 If to Varian:      
	 	Varian, Inc.	 		  	
		 	3120 Hansen Way	 		  	
		 	Palo Alto, CA 94304	 		  	
		 	Attn: Chief Financial Officer	 		  	
		 	Fax: [***]	 		  	
		 		 		  	
	 With a copy to:
	 	Varian, Inc.	 		  	
		 	3120 Hansen Way	 		  	
		 	Palo Alto, CA 94304	 		  	
		 	Attn: General Counsel	 		  	
		 	Fax: [***]	 		  	

 12.5 Governing Law and Venue. This Agreement shall be governed by, construed and enforced in
accordance with the laws of the State of Delaware, without regard to any choice of law principles. 
 12.6 Compliance with
Applicable Laws. Each Party shall comply with all provisions of any applicable laws, regulations, rules and orders in the performance of its obligations under this Agreement. 

12.7 Dispute Resolution. Any disputes arising between the Parties relating to, arising out of or in any way connected with this
Agreement or any term or condition hereof, or the performance by either Party of its obligations hereunder, whether before or after termination of this Agreement, shall be resolved exclusively and solely as follows: 

12.7.1. Oversight Committee. If the dispute cannot be resolved by the Project Managers, the Project Managers shall
promptly notify the Oversight Committee and the representatives of each Party on the Oversight Committee will meet in person at a mutually acceptable time and location within [***] of such notice and attempt to resolve the issues in dispute.

 12.7.2. Senior Management. If the dispute cannot be resolved by the Oversight Committee within [***] of
notice from the Project Managers or such extended period as the Oversight Committee may agree upon, the Oversight Committee shall promptly notify the chief executive officer of each Party (or their designee), who shall meet in person at a mutually
acceptable time and location or by means of telephone or video conference within [***] of such notice and attempt to negotiate a settlement. 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 28 

 12.7.3. Binding Arbitration. Any dispute that the chief executive
officers are not able to resolve within [***] of their first meeting, or within such extended period as they agree upon, shall be resolved exclusively and solely by binding arbitration in accordance with this Section 12.7.3. Except as specified
below, the arbitration shall be conducted in accordance with the Commercial Arbitration Rules of, and under the auspices of, the American Arbitration Association (the “AAA”) in accordance with the procedural laws of the U.S. Federal
Arbitration Act, to the extent not inconsistent with the Rules or this Section 12.7.3. 
 The arbitration
shall be conducted in Denver, Colorado by a panel of three (3) arbitrator with relevant legal, financial and/or technical expertise who are jointly selected by the Parties or, if the Parties cannot mutually agree, is selected by the AAA
administrator. The arbitration panel shall have the power to (a) grant temporary or permanent injunctive relief and to order specific performance, (b) order either Party to pay, or to allocate between the Parties, the fees and expenses of
the arbitrators and of the AAA, and (c) order either Party to pay all or a portion of the other Party’s attorneys’ fees and expenses incurred in connection with a disputed claim and the arbitration. The arbitration panel shall issue a
written decision explaining the bases for the final ruling, and such decision shall be final and binding on the Parties hereto, and not subject to appeal, and enforceable in any court of competent jurisdiction. 

12.7.4 Nothing in this Section 12.7 shall prevent either Party from seeking temporary injunctive relief to protect
its rights in its intellectual property or confidentiality obligations under this Agreement in a court of competent jurisdiction prior to arbitration. 
 12.8 Entire Agreement. This Agreement, together with the Exhibits hereto, contains the entire understanding of the Parties with respect to the subject matter hereof. All express or implied
agreements and understandings, either oral or written, heretofore made (including the [***] between the Parties with an effective date of [***]) are expressly merged in and made a part of this Agreement. In the event of any conflict or inconsistency
between any provision of any Exhibits hereto and any provision of this Agreement, the provision of this Agreement shall prevail. This Agreement may be amended, or any term hereof modified, only by a written instrument duly executed by both Parties
hereto. 
 12.9 Interpretation. The captions to the several Articles and Sections hereof and Exhibits hereto are not a
part of this Agreement, but are merely guides or labels to assist in locating and reading the several Articles and Sections hereof. The language used in the Agreement shall be deemed to be the language chosen by the Parties to express their mutual
intent, and no rule of strict construction shall be applied against either Party. 
  
 [***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 29 

 12.10 Independent Contractors. It is expressly agreed that Varian and LipoScience
shall be independent contractors and that the relationship between the two Parties shall not constitute a partnership, joint venture or agency. Neither LipoScience nor Varian shall have the authority to make any statements, representations or
commitments of any kind, or to take any action, which shall be binding on the other, without the prior consent of the other Party to do so. 
 12.11 No Third Party Beneficiaries. This Agreement shall not confer any rights or remedies upon any person other than the Parties and their respective successors and permitted assigns. 

12.12 Waiver. The waiver by either Party hereto of any right hereunder or the failure to perform or of a breach by the other Party
shall not be deemed a waiver of any other right hereunder or of any other breach or failure by said other Party whether of a similar nature or otherwise. 
 12.13 Counterparts. This Agreement may be executed by facsimile and/or in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the
same instrument. 
 IN WITNESS WHEREOF, the Parties have executed this Collaboration Agreement as of the date first set forth above. 

 

									
	LIPOSCIENCE, INC.	 		 	VARIAN, INC.
					
	 By:
	 	 /s/ Richard O. Brajer
	 		 	By:	 	 /s/ G. Edward McClammy

	 Name:
	 	Richard O. Brajer	 		 	Name:	 	G. Edward McClammy
	 Title:
	 	President and CEO	 		 	Title:	 	Senior Vice President, Chief
		 		 		 		 	Financial Officer and Treasurer

  
 30 

 *** Text Omitted and Filed Separately 

Confidential Treatment Requested 
 Under 17 CFR §§ 200.80(b)(4) and 230.406 
  

 EXHIBIT A 
 INITIAL SPECIFICATION 

  

																	
	 Document Title:
 Top Level System Requirements for the LipoScience Magnus
 NMR
LipoProfile® Analyzer
	   

  
   

						
	[LOGO]	  	Document ID:	  	Version Number:	  	 
  
	Effective Date:

DRAFT
	  
   
	  	 
  
	Supercedes Date:

N/A
	  
   
	  	 
  
	Page Number:
 3 of
20
	  
   

 Table of Contents 
  

			
	 1. INTRODUCTION
	  	
	 1.1. Applicable Documents
	  	
	 1.2. Definitions
	  	
	 1.3 Purpose
	  	
	 1.4. Project Scope
	  	
	 1.5. Functional Description
	  	
		
	 2. GENERAL SYSTEM SPECIFICATIONS
	  	
	 2.1. Physical Specifications
	  	
	 2.2. Additional physical specifications:
	  	
	 2.3. Operating Specifications
	  	
	 2.4. Startup Specifications
	  	
	 2.5. Sample Specifications
	  	
	 2.6. Reagent Specifications
	  	
	 2.7. Interface Specifications
	  	
		
	 3. OPERATING CONDITIONS
	  	
	 3.1. Facilities Specifications
	  	
	 3.2. Environmental
	  	
	 3.3. Electrical
	  	
		
	 4. TECHNICAL SPECIFICATIONS
	  	
	 4.1. Process Control Specifications
	  	
	 4.2. Fluidic Specifications
	  	
	 4.3. Cryogenic Specification
	  	
	 4.4. NMR Specifications
	  	
	 4.5. Conditioned Air Specifications
	  	
	 4.6. Environmental Specifications
	  	
	 4.7. Temperature Monitoring
	  	
	 4.7.1 Status Monitoring
	  	
	 4.7.2 Alarm Reporting
	  	
		
	 5. MAINTENANCE SPECIFICATION
	  	
	 5.1. Surface Cleaning
	  	
	 5.2. Service Times
	  	
	 5.3. Periodic Maintenance
	  	
	 5.3.1 Shift Maintenance
	  	

			
	 5.3.2 Daily Maintenance
	  	
	 5.3.3 Weekly Maintenance
	  	
	 5.3.4 Monthly Maintenance
	  	
	 5.3.5 Quarterly Maintenance
	  	
	 5.3.6 Annual Maintenance
	  	
		
	 6. SAFETY AND REGULATORY REQUIREMENTS
	  	
	 6.1. Safety
	  	
	 6.2. Regulatory
	  	
	 6.3. Labeling
	  	
	 6.4. Emissions
	  	
	 6.5. Other
	  	
		
	 7. FUNCTIONAL DESCRIPTION
	  	
		
	 8. DETAILED DESCRIPTION
	  	
	 8.1. NMR Subsystem
	  	
	 8.1.1 Magnet Assembly
	  	
	 8.1.2 Probe Assembly
	  	
	 8.1.3 NMR Control Electronics
	  	

	1.	INTRODUCTION 

  

	 	1.1	Applicable Documents 

  

	 	1.2	Definitions 

 Terms,
acronyms, and descriptions used in this document that are important to understanding the technical contents. Please refer to the LipoScience glossary to specific medical and technical terminology used in the clinical diagnostic applications for NMR
Spectroscopy. 
  

			
	 Term
	  	 Description

	 NMR
	  	Nuclear Magnetic Reasonance
		
	 NMR LipoProfile
	  	The NMR LipoProfile® test is an advanced
cardiovascular diagnostic test that uses nuclear magnetic resonance (NMR) spectroscopy to uniquely provide rapid, simultaneous, and direct measurement of: VLDL, LDL, and HDL particle subclass concentrations and sizes.

  

	 	1.3	Purpose 

 The purpose of this document is to capture certain product requirements for the LipoScience Magnus NMR LipoProfie® Analyzer (analyzer, product, system) as determined by the end user. These requirements are intended to be used by LipoScience and its development partners as input data for the generation of additional
and more detailed specifications and requirements documents. 
 In relation to a formal and typical product development process,
this document has many of the characteristics of the traditional MRD (Market Requirements Document), a PRD (Product Requirements Document) and a Functional Specification. At least Initially, this document will serve in those rolls. LipoScience is
presently engaged in a detailed business case analysis and a “Voice Of the Customer” effort. At their conclusion, separate documents may be produced. 

  

	 	1.4	Project Scope 

 These
requirements apply to the Engineering Prototype 1 (EP1) version of the LipoScience Magnus Analyzer. Additional requirements may be added to a further revision to this document or in subsequent documents. 

 

	 	1.5	Functional Description 

 The LipoScience Magnus Analyzer is an instrument that uses Nuclear Magnetic Resonance technology to provide a diagnostic evaluation of a patient’s risk for cardiovascular disease and related
maladies. This is done by detecting the response of a patient’s blood sample when placed in a magnetic field and exposed to radio frequency pulses. The resulting NMR LipoProfile® provides an improved diagnostic result over traditional Total Cholesterol, HDL, LDL and Triglyceride measurements. 

 

	2.	GENERAL SYSTEM SPECIFICATIONS 

  

	 	2.1	Physical Specifications 

It is acceptable that the system be manufactured , stored, shipped, and installed in modular components to better accommodate size and
weight issues. 
  

			
	 Maximum Weight Per Uninstalled Module:
	  	[***]
	 Maximum Height Per Uninstalled Module:
	  	[***]
	 Maximum Width Per Uninstalled Module:
	  	[***]
	 Mounting of NMR Magnet Assy:
	  	Bolted to floor

  

	 	2.2	Additional physical specifications: 

 In modular form, integral wheels may be employed for moving, placing, assembling, and leveling each module. However, the NMR Magnet assembly must be bolted to the floor and conform to all local guidelines
regarding earthquake preparedness. 
  

	 	2.3	Operating Specifications 

  

			
	 Test Throughput:
	  	[***] tests per hour
	 Total System Result Accuracy:
	  	[***] of the particle number for control
	 Unattended Operating Time:
	  	Nominally [***] hours

  
 [***] = Certain information on
this page has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  

	 	2.4.	Startup Specifications 

  

			
	Magnet Post Installation Stabilization Time:	  	[***]
	Magnet N2 Service Stabilization Time:	  	[***]
	Magnet He Service Stabilization Time:	  	[***]
	System Stabilization Time:	  	[***]
	Time to First Result:	  	[***]

  

	1 	 After installation, cryogenic filling and energizing 

	2 	 After re-filling liquid
N2 cryogenics 

	3 	 After re-filling liquid He cryogenics 

	4 	 From system start up at ambient temperature. Assumes magnet is stable. 

 

	 	2.5.	Sample Specifications 

  

			
	Sample Types :	  	Plasma, Undiluted Serum
	Supported Sample Containers:	  	TBD
	Supported Sample Tube Bar Code Formats :	  	TBD
	On-Instrument Sample Capacity:	  	[***] input samples1,3
		  	[***] post testing samples1,2,3
	STAT Capability:	  	None

  

	1 	 On-Instrument capacity is determined by unattended operating time and test throughput. 

	2 	 Post testing samples are available for a minimum of one recursive test. 

	3 	 Uninterrupted system operation during loading and unloading. 

 

	 	2.6.	Reagent Specifications 

  

			
	On Analyzer Reagents :	  	3 containers’2, TBD mL min. each
	Wash Fluid Storage1,2:	  	TBD L
	Fluid Waste1,2:	  	TBD L

  

	1 	 Continuous load and unload, auto priming if priming is required 

	2 	 Non-environment controlled 

  

[***] = Certain information on this page has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  

	 	2.7.	Interface Specifications 

  

			
	Laboratory Information System Compatibility:	  	TBD1
	External Communication:	  	Ethernet LAN/WAN (TCP/IP), RS232, Modem
	User Interface:	  	Touch Screen LCD, Keyboard

  

	1	Possible Laboratory Information Systems: ALS (Advanced Laboratory Systems), Antrim, Biovation, Cerner, Clinicomp, Intl., Creative Computer Applications, Inc., Dynacor,
Inc., Dynamedix Corporation, Dynamic Healthcare, HBO & Company, IDX, JRS, Key communications Service, Inc., Medical Manager, Meditech, SCC (Soft), Sunquest 

  

	3.	OPERATING CONDITIONS 

  

	 	3.1.	Facilities Specifications 

  

			
	Floor :	  	Able to support [***]ibs per sq floor
	Floor Space:	  	TBD cm x TMD cm
	Celling Height:	  	[***]
	Power:	  	One dedicated [***]VAC@[***]A
	Vibration :	  	TBD

  

	 	3.2.	Environmental 

  

			
	Storage/Shipping Temp:	  	[***]
	Ambient Operating Temp :	  	[***]
	Storage/Shipping Humidity:	  	[***]
	Ambient Operating Humidity:	  	[***]
	Storage/Shipping Shock :	  	TBD Max
	Operating Shock:	  	TBD Max
	Storage/Shipping Vibration :	  	TBD Max
	Operating Vibration :	  	TBD Max

  

	 	3.3.	Electrical 

 The system
shall internally accommodate two input power range over the described frequency. This will allow for use in international markets as well as providing wide acceptance in the U.S. 

 

			
	Power Rating:	  	TBD KVA max
	Input Voltage Frequency :	  	[***]
	Input Voltage Range #1:	  	[***]
	Input Current #1:	  	TBD Amps Max @ [***]1VACrms
	Uninterrupted Power System :	  	10 minute duration for controlled shut down. Available as an external option

  
 [***] = Certain information on
this page has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  

	4.	TECHNICAL SPECIFICATIONS 

  

	 	4.1.	Process Control Specifications 

  

			
	 Host Computer:
	  	Embedded Single Board Pentium Class
	 RAM:
	  	1GB min
	 Hard Disk Storage:
	  	>60 GB
	 Bus Type:
	  	PCI
	 Operating System:
	  	Multi-User, Multi-Tasking1
	 General A/D Data Acquisition Channels:
	  	TBD differential input channels @16 bit
	 D/A Output Channels:
	  	TBD channels, 0 to 10V @12 bits min
	 Digital I/O Lines:
	  	TBD input/output, independently programmable
	 Motion Control:
	  	 TBD axis, ±10V Analog DC Servo
 TBD axis, full/half step open loop stepper

	 Serial Communication Channels:
	  	TBD channels RS232 @19.2KB max2
	 Internal Network Connection:
	  	100BaseT
	 External Network Connection:
	  	100BaseT
	 Network Protocol(s):
	  	TCP/IP
	 Display:3
	  	14 in . SVGA LCD Touch Panel 1024x768 @256 color

  

	1 	 Windows XP Embedded for example 

	2 	 Includes one channel for external communication 

	3 	 Size, resolution, and color depths are minimum specifications 

 

	 	4.2.	Fluidic Specifications 

  

			
	 Max Aspirate Sample Volume per Test:
	  	TBD μl
	 Max Aspirate Reagent Volume per Test:
	  	TBD μl
	 Aspirate/Dispense Rate:
	  	TBD μl/sec to TBD μl/sec
	 Aspirate/Dispense Precision:
	  	<TBD%
	 Reagent Container Dead Volume:
	  	[***] of reagent capacity
	 Wash Container Dead Volume:
	  	[***] of reagent capacity
	 Diluent Container Dead Volume:
	  	[***] of reagent capacity
	 Total Intra-System Sample Carryover:
	  	[***] per test, non-cumulative
	 Total Intra-System Reagent Carryover:
	  	[***] per test, non-cumulative

  
 [***] = Certain information on
this page has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  

	 	4.3.	Cryogenic Specification 

  

			
	Liquid Nitrogen Volume:	  	Nominally 100 L1
		
	Liquid Helium Volume:	  	Nominally 100 L1

  

	1	This value provided as a reference. The actual value will be determined by the design of the NMR Subsystem 

 

	 	4.4.	NMR Specifications 

  

			
	Field Strength:	  	[***]
		
	Shielding:	  	[***]
		
		  	[***]
		
	Channels:	  	Lock, Proton
		
	H Amplifier Power:	  	[***]
		
	Pulsed Field Gradients:	  	[***]
		
	Auto Proton Gradient Shimming:	  	Required, [***]
		
	Auto Deuterium Gradient Shimming:	  	Required, [***]
		
	Line Width:	  	[***]
		
		  	[***]
		
		  	[***]
		
	Active Flow Cell Volume:	  	[***]
		
	Sample Temperature to Preheater:	  	[***]
		
	Sample Preheat Control2:	  	[***]
		
	Probe Flow Cell Temperature Control2:	  	[***]

  

	1	Test sample is chloroform in acetone 

  

	2	Control of preheater and flow cell heater set by system level and controlled by the NMR Subsystem. 

 

	 	4.5.	Conditioned Air Specification 

 All conditioning of system air (moisture and participate) will be done internal and onboard the system. Available of external source of air is TBD 

 

			
	System Air Pressure:	  	60 psi Nominal
		
	System Air Flow:	  	11.6 liters Per minute nominal
		
	System Air Filtering:	  	TBD
		
	System Air Humidity:	  	TBD

  
 [***] = Certain information on
this page has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  

	 	4.6.	Environmental Specifications 

  

			
	 Reagent Temperature Control1:
	  	TBDoC to TBDoC, ±1oC
	 Sample Pre-Heat Temperature Control1:
	  	[***]
	 Probe Flow Cell Temperature Control1:
	  	 [***]

  

	3 	 Programmable under computer control 

  

	 	4.7.	Temperature Monitoring 

  

			
	 Reagent Storage Temperature:
	  	±TBDoC min resolution
	 Sample Pre-Heat Temperature:
	  	±TBDoC min resolution
	 Probe Flow Cell Temperature:
	  	±TBDoC min resolution
	 Ambient Temperature at Magnet Base:
	  	±TBDoC min resolution
	 Ambient Temperature at Magnet Top:
	  	±TBDoC min resolution
	 Laboratory Ambient:
	  	±TBDoC min resolution
	 Electronics Point #1:
	  	±TBDoC min resolution
	 Electronics Point #2:
	  	±TBDoC min resolution
	 Exhaust Air Point #1:
	  	±TBDoC min resolution
	 Exhaust Air Point #2:
	  	±TBDoC min resolution

  

	 	4.7.1	Status Monitoring 

  

			
	 Reagent Levels :
	  	Low1, Empty
	 Liquid Waste Level:
	  	Almost Full2, Full
	 Solid Waste Level:
	  	Almost Full2, Full
	 Liquid N2 Level:
	  	Continuous
	 Liquid He Level:
	  	Continuous
	 Covers, Doors, etc.
	  	Open/closed status, all user accessible cases

  

	1	“Low” is defined as 10-20% 

	2	“Almost Full” is defined as 80-90% 

  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  

	 	4.7.2	Alarm Reporting 

(Response and corrective actions will be described and defined in subsequent software specifications.) 

U – User Interface, A1 – Single Audible Alarm, A2 – Continuous Audible Alarm 

 

			
	Out of Temperature Range1:	  	U, A1
	Reagent Inventory Low:	  	U, A1
	Reagent Inventory Empty:	  	U, A2
	Sample Error2:	  	U, A2
	Waste Container(s) Near Full:	  	U, A1
	Waste Container(s) Full:	  	U, A2
	Liquid N2 Level Low:	  	U, A2
	Liquid He Low:	  	U, A2

  

	1 	 For all monitored temperatures 

	2 	 Short sample, clot detection 

  

	5.	MAINTENANCE SPECIFICATION 

  

	 	5.1.	Surface Cleaning 

 All
surfaces subject to spills and/or routine cleaning shall be compatible with disinfectant solutions that may contain up to 10% bleach. 
  

	 	5.2.	Service Times 

  

			
	Per Shift Maintenance:	  	£TBD minutes by Lab Technician
	Daily Maintenance:	  	£TBD minutes by Lab Technician
	Weekly Maintenance:	  	£TBD minutes by Lab Technician
	Monthly Maintenance:	  	£TBD minutes by Lab Technician
	Four Month Periodic Maintenance:	  	£TBD minutes by Factory Service
	Mean Time between Unscheduled
Service Call:	  	TBD Months

  

	 	5.3.	Periodic Maintenance 

 All
maintenance requirements are incremental, i.e. Shift and Daily maintenance should be performed in addition to Weekly maintenance. 
 Abbreviations: 
 O – Operator 

LT – Lab Tech 
 FSR – Factory Service Rep 
 Definitions: 

“Mandatory” – Perform as scheduled 
 “As Req’d” – Perform if indicated after visual inspection. 
  

	 	5.3.1	Shift Maintenance 

  

							
	Item	 	Personnel	 	Level	 	Freq
	     Reagent Inventory
	 	O, LT	 	As Req’d	 	
	     Liquid & Solid Waste Levels
	 	O, LT	 	As Req’d	 	
	     Inspect for spills
	 	O, LT	 	As Req’d	 	

  

	 	5.3.2	  Daily Maintenance 

  

							
	Item	 	Personnel	 	Level	 	Freq
	     Empty Air Fluid Container
	 	LT	 	As Req’d	 	

  

	 	5.3.3  Weekly	Maintenance 

  

							
	Item	 	Personnel	 	Level	 	Freq
	     Fill Liquid Nitrogen
	 	LT	 	As Req’d	 	BI-weekly

  

	 	5.3.4	  Monthly Maintenance 

  

							
	Item	 	Personnel	 	Level	 	Freq
	     Fill Liquid Helium
	 	FSR	 	Mandatory	 	3 months
	     Replace Air Filters
	 	O, LT	 	As Req’d	 	

  

	 	5.3.5	  Quarterly Maintenance 

  

							
	Item	 	Personnel	 	Level	 	Freq
		 		 		 	

  

	 	5.3.6	  Annual Maintenance 

  

							
	Item	 	Personnel	 	Level	 	Freq
		 		 		 	

	6.	SAFETY AND REGULATORY REQUIREMENTS 

  

	 	6.1.	Safety 

  

			
	 IEC:
	  	
61010-11
 Safety Requirements for Electric
 Equipment for Measurement, Control,
 and Laboratory Use

	 IEC:
	  	 61326
 Electrical Equipment
for Measurement,
 Control and Laboratory Use – EMC
 requirements

	 CSA:
	  	 C22.2 1010-11
 Safety
Requirements for Electric
 Equipment for Measurement, Control,
 and Laboratory Use

  

	1	Equivalent to UL 61010B-1 

 Other
safety requirements: 
 Magnetic Field – TBD 
 RF Energy Emission – TBD 
 Cryogenics Materials Safety – TBD 

 

	 	6.2.	Regulatory 

  

			
	 Electronic Data:
	  	21 CFR Part 11
	 European:
	  	European Directive 98/79/EC (IVDD)

  

	 	6.3.	Labeling 

  

			
	CE:	  	 3/374/EEC
 Instructions for
Use for In Vitro Diagnostic Instruments for Professional Use

	British Standard/European Standard:	  	 BS EN 1658:1997

Requirements for Marking of In Vitro Diagnostic Instruments

	ISO:	  	 ISO 15223:2000, AMD 2:2004

Symbols to be used with Medical Device Labels, Labeling and Information to be Supplied

	FDA:	  	 21 CFR 809
 Labeling for In
Vitro Diagnostic for Human Use

  

	 	6.4.	Emissions 

  

			
	IEC:	  	 61326
 Electrical Equipment
for Measurement, Control and Laboratory Use – EMC requirements

		
	FCC:	  	Part 15

  

	 	6.5.	Other 

  

			
	British Standard/European Standard:	  	 BS EN 591:2001
 Instructions
for Use for In Vitro Diagnostic Instruments for Professional Use

  

	7.	FUNCTIONAL DESCRIPTION 

 The LipoScience Magnus Analyzer utilizes proprietary nuclear magnetic resonance (NMR) spectroscopy to provide rapid, simultaneous and direct measurement of LDL particle number and size of LDL particles,
as well as direct measurement of HDL and VLDL subclasses. The LipoScience NMR LipoProfile@ test is an advanced cardiovascular diagnostic test that provides detalied lipoprotein particle information thus allowing clinicians to make effective individualized treatment decisions than previously
possible based on standard lipid panel testing. 
 The basic steps in performing the NMR LipoProfile® test are: 
 [***] 
 NOTE: Depending on the design approach taken for sample handling and other
aspects of the system, the order of the above steps may be different. 
  

	8.	DETAILED DESCRIPTION 

  

	 	8.1	NMR Subsystem 

 The NMR
Subsystem consists of three main components: 
  

	 	8.1.1	Magnet Assembly 

 The NMR
Magnet Assembly consists of a shielded superconducting magnet contained in an enclosure. Although shielded, it is expected that the magnetic field would not be fully contained within the enclosure. Although the residual external field should not
represent a health and safety issue, it may extend the working space around the analyzer beyond the perimeter of the analyzer. This presence of this external residual field may negatively affect the performance of the analyzer. For example, if a
typical metal 
  
 [***] = Certain information on this
page has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  

 
laboratory cart were to be rolled within the area of the external residual field, it may cause a perturbation in the field sufficient enough to affect the test results. Validation testing will
have to be performed to determine the final effective system perimeter around the analyzer. 
 In order to achieve the necessary
magnetic field strength, the magnet consists of a superconducting core. It is expected that supercooling of the magnet will be achieved by immersing it in liquid helium. The supercooled core would then be contained within a liquid nitrogen
“shell” for the purpose of reducing the evaporation and subsequent depletion of the more expensive liquid helium. 
 It
is expected that replenishment of the liquid nitrogen and liquid helium would nominally be required at two week and 3 month intervals respectively. It is intended that the liquid nitrogen would be replenished by a trained laboratory technician and
the liquid helium would be replenished by a factory service technician. It is important that the Magnet Assembly be designed such that the replenishment of the cryogenics can be performed in a safe manner by the appropriate personnel. 

The NMR Magnet Assembly will be quite heavy and because it must be mounted above the floor in order to provide access to the underside,
the center of gravity is also high. This represents a significant safety risk, especially in areas notable for earthquake activity. For this reason, it shall be necessary to secure the NMR Magnet Assembly by bolting it to the floor. The mounting
method must also accommodate any necessary features required for leveling. 
  

	 	8.1.2  	Probe Assembly 

 There are
two basic approaches to the NMR Subsystem as it related to sample presentation. One is a flow through approach where the sample flows through tubing into a flow cell contained within the probe. The second is a tube based approach whereby the sample
is contained within an NMR Tube Which Is Then Inserted Into The Probe. In More typical NMR applications, it is necessary to spin the NMR tube during measurement in order to mitigate the anomalies within the tube such as dimensional variance and
contaminates in the glass material. It is not yet known if spinning would be required for the Magnus Analyzer. 

  

 For the Purposes of conducting the LipoScience NMR Lipoprofile®, the probe shall consist of lock and proton channels. It is not necessary that additional channels be supported.

  

	 	8.1.3	NMR Control Electronics 

The NMR Subsystem is controlled by the NMR Control Electronic (Console). The main responsibility of the console is to perform a data
acquisition sequence resulting in resonance spectral response from the sample being tested. This spectral data shall be passed onto the systems level computer for analysis and the determination of a clinical result. 

The Console is also responsible for performing automated calibration and setup functions. The NMR Subsystem as a whole must have the
capability of operating unattended for relatively long periods of time. It is therefore necessary that the NMR Subsystem have the ability to detect and correct for conditions that would otherwise result in unacceptable results. 

  

 *** Text Omitted and Filed Separately 

Confidential Treatment Requested 
 Under 17 CFR §§ 200.80(b)(4) and 230.406 
  

 EXHIBIT B 
 INITIAL DEVELOPMENT PLAN 
  
 

 
 Preliminary Product Development Plan 

February 28, 2005 
 The
Opportunity 
  
 LipoScience is a
“medical technology company dedicated to developing and marketing clinical diagnostic applications of nuclear magnetic resonance, or NMR spectroscopy.” Established in 1997, LipoScience has the largest centralize NMR laboratory in the
world, located in Raleigh, North Carolina. 
 Through its NMR Lipoprofile® test, LipoScience has developed an improved method of assessing risks for coronary heart disease by quantifying the
number of lipoproteins in a person’s blood. These lipoproteins are the transport mechanism for cholesterol in the body. “Numerous studies have confirmed that knowing the number of Low Density Lipoprotein Particles (LDL) is a superior
predictor of heart disease when compared to all cholesterol measurements. Currently, in the United States 50% of people that experience a heart attack have cholesterol numbers that would be considered normal.” 

In order to grow its business, LipoScience desires to supplement its centralized laboratory structure and to create a business model
that Places NMR-based equipment into a clinical laboratory. Using the LipoPnofile® test as the lead
application, this new business model would simplify sample collection and distribution, reduce sample transportation costs, and accelerate the adoption of this test as a standard of care for assessing the risk of coronary heart disease. To
accomplish this, it is necessary to develop a “clinical-friendly” NMR system. Specifically, LipoScience desires an NMR system with a simplified user interface, focused operating features, a smaller footprint, and lower cost compared to
existing NMR systems. 
 The Approach 

 
 Three discrete phases are currently envisioned
for this program, as outlined below. Only Phase 1 is proposed at this time. 
  

	•	 	 Phase 1. Concept Development 

  

	•	 	 Phase 2. Detailed Design and Prototype Fabrication 

  

	•	 	 Phase 3. Clinical Trial Fabrication 

  

 The program overview is summarized in the attached table. Draft budgetary and time estimates for Phases 2
and 3 are also presented. These estimates will be refined at the conclusion of Phase 1, once more is understood about the system architecture and design strategy. 
 [***] will serve as the prime contractor and will lead the systems integration effort. In conjunction [***], [***] will be responsible for the following activities, as requested by LipoScience:

 [***] 
 To reduce the overall
program risk for LipoScience, we will develop and maintain a Risk Management Plan (RMP). This will help LipoScience manage the business risks as they apply to the development elements of the project. 

Phase 1. Concept Development 
 The goal
of Phase 1 is to provide LipoScience with a clear system design concept for moving into detailed design activities. Phase 1 tasks and durations are shown in the attached Gantt chart. 
 It is envisioned that a joint team kick-off meeting will occur in early April. This will include LipoScience, [***], [***], and the Varian. The program plan will be revised as needed and roles and
responsibilities will be clarified. Initial results of LipoScience’s MRD interviews will be reviewed, as well as updates to the Top Level Requirements Document. Program priorities and metrics for design trade-off analyses will be established.

 Team members will then accompany LipoScience staff to meet with selected clinical partners and/or major hospitals to better understand the
clinical drivers for the Magnus System. This “immersion” will give the design team first-hand insight into the needs of the clinical operators and administrators. 
  
 [***] = Certain information on this page has been omitted and filed separately with the Securities and

 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  

 A meeting is also proposed at the Varian to understand its existing technology, specific development
timeframes, and design challenges and constraints. A review will also be made of its existing software code and procedures. 
 System concepts
will be generated by the joint team, as well as through internal [***] brainstorming sessions. Industrial design sketches of key concepts will be created, focusing on user interaction and overall layout of the various subsystems. A brief theory of
operation will be created. The overall system architecture—both hardware and software domains—will be developed and initial subsystem partitioning will be defined. An updated Functional Requirements and draft Hazard Analysis will be
created. 
 Based on the initial concepts, preliminary mechanical design layouts will be generated to evaluate volumetric sizing and subsystem
placement. Overall power distribution and subsystem control layout will be drafted. Finally, based on initial system assumptions, a preliminary unit manufacturing cost estimate will be generated. 

Software, development will be an integral part of the overall system design. Battelle will coordinate software activities at LipoScience and the Varian.
A Software Quality Assurance Plan (SQAP) will be developed in Phase 1 to establish ground rules for all software development. As LipoScience and the Varian currently do not have procedures for developing software under the FDA’s QSR, [***] will
help educate the team members and define procedures as necessary. Software development tools, version tracking procedures, and problem reporting tools will be established for collaborative development. 

To foster open communication and real-time information sharing, an e-Room (a secure web-based, electronic file sharing tool) will be established on [***]
servers to allow team members access to appropriate procedures, documents, test results, and deliverables for the project. Interactive “real-time” design reviews will be held with all development partners using web-based tools, such as MS
Placeware. Weekly project conference calls or videoconferences will be held to review project status, action items, and issues. Monthly project metric reviews will be held to review costs, schedules, and deliverable status. 

 
 [***] = Certain information on this page has
been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested with
respect to the omitted portions. 

  

 Deliverables 

 
 The planned deliverables for this Phase 1 effort
are the following: 
 [***] 

Project Team 
  

An experienced design team has been established to assist LipoScience in the development of the Magnus System. Besides these individuals, we will reach a
broad array of technical specialists at [***], as required to address the specific needs that arise as the project unfolds. 
 [***] 

Estimated Cost and Schedule 
  

Schedule: [***] 
 Professional
Fees: [***] 
 Key Assumptions 

 
 The key assumptions used to generate this
proposal include the following: 
 [***] 
  

[***] = Certain information on this page has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.Exhibit 10.10

 Exhibit 10.10 
 *** Text Omitted and Filed Separately 
 Confidential Treatment Requested 

Under 17 CFR §§ 200.80(b)(4) and 230.406 
 PRODUCTION AGREEMENT 
 THIS PRODUCTION AGREEMENT (the
“Agreement”), effective as of June 26, 2009 (the “Effective Date”), by and between LIPOSCIENCE, INC., a Delaware corporation, (“LipoScience”) and KMC SYSTEMS, INC., a Delaware
corporation (“KMC”). Capitalized terms used in this Agreement and not defined in this Agreement have the meaning given them in the Development Agreement. 
 WHEREAS, LipoScience possesses proprietary technology and information related to the Instrument (as defined in Section 1); 

WHEREAS, KMC has expertise in the design, development and manufacture of medical instrumentation and equipment; and 

WHEREAS, LipoScience desires to appoint KMC, and KMC desires to accept LipoScience’s appointment, as LipoScience’s
exclusive manufacturer of the Instrument on the terms and conditions set forth herein. 
 NOW, THEREFORE, in
consideration of the mutual representations, warranties and covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties agree as follows: 

 

	 	1.	DEFINITIONS 

 As used in
this Agreement: 
 1.1 “Affiliate” means any corporation, firm, partnership or other entity that controls, is
controlled by, or is under common control, with a party. For the purposes of this definition, “control” shall mean the ownership of at least 50% of the voting share interests of such entity or any other comparable equity or ownership
interest. 
 1.2 “ATP” means the Acceptance Testing Procedures developed by KMC and mutually reviewed and
approved by LipoScience and KMC. 
 1.3 “Business Day” means a day that is not Saturday, Sunday or a federal,
New Hampshire or North Carolina holiday on which commercial banks are closed for business in New Hampshire or North Carolina. 

1.4 “Development Agreement” means that certain Development Agreement dated November 16, 2007 between KMC Systems,
Inc. and LipoScience, Inc. 
 1.5 “Dollars” or “$” means United States dollars. 

1.6 “ECO” means an Engineering Change Order, a standard KMC document used to control incorporation of changes in the
TDP, as set forth in Section 9.2 hereof. 

  
 1 

 1.7 “Forecast” shall have the meaning set forth in Section 7.1 hereof.

 1.8 “Effective Date” shall have the meaning set forth in the introduction to this Agreement. 

1.9 “FDA” means the United States Food and Drug Administration or any successor agency thereof. 

1.10 “Initial Term” shall have the meaning set forth in Section 13.1 hereof. 

1.11 “Instrument” means a commercial production unit of the Numera, based upon the technology and consisting of the
elements described in Appendix I attached to this Agreement and made a part hereof, together with all future upgrades, modifications and derivatives thereof manufactured by KMC pursuant to this Agreement. 

1.12 “Intellectual Property” means all patentable and unpatentable inventions, ideas, discoveries, improvements,
design rights, works of authorship, copyrights, patents, patent applications, trade secrets, know-how and any equivalent thereof; notwithstanding the foregoing, Intellectual Property excludes the [***] and any [***], and any [***] and [***] related
to the [***] and [***] by [***]. 
 1.13 “ISO” means maintaining a quality system certified by a notified body
to the International Standards Organization Quality System Standard ISO 13485. 
 1.14 “Marks” shall have the
meaning set forth in Section 5.4 hereof. 
 1.15 [***] means that certain [***] between [***] and [***] regarding [***]
planned [***] for the [***]. 
 1.16 “Purchase Commitment” shall have the meaning set forth in Section 7.2
hereof. 
 1.17 “Purchase Order” shall have the meaning set forth in Section 6.1 hereof. 

1.18 “QSR” means the Quality System Regulation 21 of the Code of Federal Regulations, part 820, for the development and
manufacture of medical devices and in-vitro diagnostic products. 
 1.19 “Quality Plan” means the KMC
Manufacturing Quality Plan prepared by KMC and approved by LipoScience, which defines the procedures, practices and requirements for the manufacture of the Instrument by KMC. 
 1.20 “Statements” shall have the meaning set forth in Section 10.2 hereof. 
 1.21 “TDP” means the technical data package for the Instrument which includes, without limitation, detail mechanical drawings, assembly drawings, component specification drawings, bill of
materials, schematic and assembly drawings, specifications relating to all of the foregoing, and the ATP, which TDP shall be treated as confidential and proprietary information.by both parties hereto. The TDP shall be owned by LipoScience.

  
 [***] = Certain information on this page, marked
by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  
 2 

 1.22 “Term” means the Initial Term and any extension of the Initial Term
pursuant to Section 13 hereof. 
 1.23 “Unit Sale Price” shall have the meaning set forth in
Section 8.1 hereof. 
 1.24 “Work Request” means a standard KMC document proposing changes, or additions
of work scope to the then existing agreed upon scope of services and work to be performed by KMC. A Work Request will state the reason or basis of the request, an estimate of the anticipated costs associated with such change and an estimate of the
impact on the schedule and the Unit Sale Price. 
 1.24 “Work Product” shall have the meaning set forth in
Section 14.1 of the Development Agreement. 
  

	 	2.	EXCLUSIVITY 

 2.1.
Exclusivity. LipoScience and its Affiliates shall, directly and indirectly, throughout the Term purchase all of their United States’ requirements for the Instrument exclusively from KMC, and KMC shall produce for and sell to LipoScience
and its Affiliates all of their United States’ requirements for the Instrument, all on the terms and conditions of this Agreement. [***] shall have the [***] to [***] to the extent that [***]. Any [***] with respect to such [***] of [***] shall
be at [***] expense and, to the extent [***] or [***] would be [***] to such [***], shall be [***] to such [***] with [***]. In the event [***] is unable to [***] in accordance with the [***] set forth in the [***] for a period of [***] and such
[***] is due to [***], then [***] under this Section. 
  

	 	3.	REGULATORY RESPONSIBILITY 

3.1 LipoScience Regulatory Responsibility. LipoScience shall be responsible for all submissions in connection with, and for
obtaining, all advisable or necessary regulatory approvals to develop, manufacture, market, distribute and sell the Instrument. LipoScience shall also be responsible for all follow-up communications and actions with regulatory agencies
related to the development, manufacture, marketing, distribution and sale of the Instrument, including, but not limited to, compliance with any export regulations, device tracking requirements and medical device reporting. KMC shall assist and
support these efforts related to the Instrument as reasonably required by LipoScience and at LipoScience’s expense, and shall permit as part of its support efforts any applicable regulatory authority to inspect the KMC manufacturing facility as
it may relate to the Instrument or the services provided by KMC hereunder and as required under applicable law or regulation. 

3.2 KMC Regulatory Responsibility. KMC agrees that it shall, at all times during the term of this Agreement, maintain (i) an
FDA and ISO registered medical device manufacturing facility, in compliance with applicable QSR regulations; (ii) all records related to 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 3 

 
the Instrument as required by applicable United States law and regulation; and (iii) otherwise comply in all material respects with applicable FDA, ISO and QSR laws and regulations with
respect to the manufacture of the Instrument under this Agreement. 
  

	 	4.	TOOLING AND TEST EQUIPMENT 

KMC will purchase, with LipoScience’s approval and at LipoScience’s expense in accordance with Section 10.1, or LipoScience
will supply at its expense, all necessary tooling and test equipment for the build, test and delivery of the Instruments. All such tooling and test equipment paid for (or supplied) by LipoScience in accordance with the provisions of this Agreement
shall remain the property of LipoScience. KMC shall safeguard and maintain such tooling and test equipment in the same manner as it does its own tooling and equipment, but not less than a reasonable manner taking into consideration the nature of the
equipment, provided that LipoScience shall be responsible for payment of all maintenance beyond ordinary and routine maintenance and for refurbishment and/or replacement of such tooling and test equipment, unless such refurbishment and replacement
of any tooling and test equipment is due to the negligence or intentional misconduct of KMC. All tooling and test equipment developed or owned by KMC prior to the Effective Date and all tooling and test equipment not paid for (or supplied) by
LipoScience shall remain the property of KMC. 
  

	 	5.	PRODUCTION OF INSTRUMENTS 

5.1 Production of Instruments. Upon release of the final TDP and receipt of the Purchase Orders (as defined in Section 6) for
the Instruments from LipoScience which are accepted in accordance with Section 6.2 hereof, KMC will build, test, label and ship the Instruments in accordance with applicable manufacturing quality plan and the TDP. 

5.2 Acceptance Testing Procedure. Instruments manufactured by KMC shall be subjected to the ATP prior to shipment, and shall be
deemed accepted by LipoScience upon meeting the requirements of the ATP, as confirmed by KMC’s written certification provided to LipoScience. Title to the Instruments, and risk of loss thereof, shall remain with KMC for so long as KMC is in
possession of the Instruments, and shall transfer to LipoScience upon shipment to (i) LipoScience, (ii) LipoScience’s designated customer, or (iii) a storage facility designated by LipoScience. 

5.3 Materials. LipoScience will supply to KMC at LipoScience’s expense all reagent and disposable materials necessary to
perform the ATP. 
 5.4 Instrument Markings. During the term of this Agreement, KMC shall attach or affix to the
Instruments in a manner and as directed by LipoScience such trademarks, tradenames and logos, and patent legends as LipoScience may designate from time to time (collectively, the “Marks”), all of which LipoScience shall be
responsible for assuring meet the representations and warranties of Section 15. 

  
 4 

 5.5 Primary Contacts. KMC and LipoScience shall each identify an individual who has
the primary responsibility for maintaining contact and communication with the other with regard to this Agreement. 
 5.6
Post-Production Services. Subject to the parties negotiating a mutually agreeable support services agreement, KMC shall provide post-production services in support of the Instruments. These services may include, without limitation:
procurement and production of spare parts and/or sub-assemblies, management of spare parts/sub-assembly inventory (including shipments to field service sites), development of test equipment and procedures for testing of spare parts/sub-assemblies
and/or post-warranty repair and refurbishment services. The parties shall negotiate a separate support services agreement to cover any such support services. 
  

	 	6.	PURCHASE ORDERS 

 6.1
Purchase Orders. Subject to Section 8 hereof, LipoScience shall submit written purchase orders by registered mail, facsimile or email, addressed to the attention of the KMC Business Development Department. Each purchase order (a
“Purchase Order”) will contain an express reference to this Agreement and will state (i) the desired quantity of units of the applicable Instrument(s) to be produced under such Purchase Order, and the Unit Sale Price for such
Instrument determined in accordance with Section 8 hereof; and (ii) the requested shipping schedule, which shall commence no earlier than the longest lead time of any material set forth on Schedule 1 attached hereto [***], as Schedule 1
may be modified by the parties in writing from time to time. With the exception of such quantity, Unit Sale Price and completion schedule, all other terms and conditions of any Purchase Order shall be void and of no force or effect. 

6.2 KMC Review of Purchase Orders. KMC will provide to LipoScience a written response to each Purchase Order within [***] Business
Days of KMC’s receipt of such Purchase Order, indicating either that the above terms of the Purchase Order respecting quantity, shipping schedule and shipping instructions are acceptable as stated, or setting forth necessary adjustments. If KMC
fails to respond to LipoScience within said [***] Business Days, the Purchase Order shall be deemed accepted by KMC as issued by LipoScience with respect to the quantity(ies), Unit Transfer Price(s) and completion date(s) set forth therein.
Likewise, if LipoScience fails to respond to KMC’s written response within [***] Business Days of LipoScience’s receipt of such written response, then the modifications to the Purchase Order set forth in such KMC written response shall be
deemed accepted by LipoScience. 
 6.3 Production Delays. In the event KMC’s production activities under a Purchase
Order are interrupted and/or delayed for any continuous period in excess of [***] calendar days due to a request of LipoScience or the failure by LipoScience to fulfill its obligations under this Agreement, then KMC reserves the right to immediately
invoice LipoScience, [***], for all reasonable expenses incurred by KMC as a direct result of such delay or interruption. [***] means the [***] of [***] and [***] for the [***] as set forth in [***]. [***] shall [***] with [***] along with any [***]
under this Section 6.3. KMC will use reasonable efforts to avoid and/or minimize such expenses, by using reasonable efforts to reallocate internal resources and attempting to negotiate alternative arrangements with outside material suppliers.

  
 [***] = Certain information on this page, marked
by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  
 5 

	 	7.	RESERVED 

  

	 	8.	UNIT SALE PRICE FOR THE INSTRUMENT 

 8.1 Unit Sale Price. The unit sale price for each Instrument will be determined on a Purchase Order-by-Purchase Order basis and shall be based on the pricing formula set forth on Schedule 2
attached to this Agreement (the “Unit Sale Price”) for the Instrument. The initial Unit Sale Price shall be established by KMC upon release of the final TDP and shall be subject to future adjustments pursuant to application of the
pricing formula as set forth on Schedule 2. Prior to LipoScience’s submission of each Purchase Order, LipoScience shall inform KMC of the number of units of each Instrument that LipoScience proposes to order. Upon request by LipoScience, KMC
shall within [***] days thereafter obtain vendor quotes for the applicable quantity of Instruments and provide to LipoScience the Unit Sale Price for that number of units. Upon LipoScience’s final determination of the number of units of each
Instrument that LipoScience proposes to specify in its Purchase Order, the parties shall calculate and mutually agree upon the Unit Sale Price(s) of such Instrument(s). 
 8.2 Adjustments to Unit Sale Price. 
 (a) Increase in
Cost of Materials. In the event the cost of materials increases as a result of a delay or interruption in KMC’s production activities due to a request of LipoScience or the failure of LipoScience to fulfill its obligations under this
Agreement, the then Unit Sale Price shall be increased to reflect such increase in cost of materials. 
 (b)
Unrealized Labor Efficiencies. The parties acknowledge and agree that the Unit Sale Price takes into account the cost of labor for the continuous production of units of the Instrument. To the extent less than such agreed upon units of the
Instrument are produced or such minimum run-rate is interrupted due to the request of LipoScience or the failure of LipoScience to fulfill its obligations under this Agreement, the then Unit Sale Price shall be adjusted by KMC to reflect the
negative impact on the actual labor costs caused by such change. 
 (c) Decrease in Cost of Materials. In
the event the cost of raw materials is decreased based on action initiated by LipoScience, the then Unit Sale Price shall be decreased by KMC by an amount equal to [***] of the reduction in the cost of raw materials plus applicable overhead. In the
event the cost of raw materials is decreased based on action initiated by KMC, the then Unit Sale Price shall be decreased by [***] of the reduction in the cost of raw materials plus [***]. 

8.3 Adjustments to Unit Sale Price. Commencing with [***], KMC shall have the right to adjust the then Unit Sale Price to reflect
[***] increases in its labor costs effective upon not less than [***] days’ prior written notice to LipoScience. 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 6 

 8.4 Sale of Instruments to Varian, Inc. and its Affiliates. During the Term of this
Agreement, Varian, Inc. and its Affiliates (collectively, the “Varian Parties”) shall have the option to purchase Instruments and spare parts from KMC on terms that taken as a whole are no less favorable as set forth in this Agreement and
the Spare Parts Agreement, dated the date hereof between the parties. Notwithstanding the foregoing, the limitation of liability and security provisions for the agreements between Varian and KMC shall be mutually agreed to at such time and
shall not be subject to the preceding sentence. 
  

	 	9.	WORK SCOPE CHANGES 

 9.1
Work Scope Changes. Either LipoScience or KMC may, from time to time, propose a change in, or an addition to, the work scope in accordance with this Section. Such proposed change or addition may be a change in the TDP or additional work that
is required or recommended to satisfy the overall goals and requirements of LipoScience. 
 9.2 Process for Work Scope
Changes. If LipoScience proposes such change or elects to proceed with consideration of any proposed change by KMC, KMC will prepare and submit to LipoScience a written Work Request. After its receipt of the Work Request, LipoScience, in its
sole discretion, will determine whether or not to approve the Work Request. If LipoScience determines to proceed with the changes detailed in the Work Request, then within ten (l0) Business Days after its receipt of the Work Request, LipoScience
will notify KMC of that determination by signing and returning to KMC the subject Work Request. Failure to respond to KMC within such ten (10) Business Days shall constitute a rejection of the Work Request. KMC will implement changes approved
by LipoScience in writing in accordance with the Work Request and the provisions of Section 9.3 below. All changes to the TDP will be effected by an ECO approved by both parties in writing. 

9.3 Invoicing for Services Rendered Under Work Request. Unless otherwise stated on the Work Request, KMC will submit invoices to
LipoScience on a monthly basis for actual expenses incurred, and for services rendered by KMC, in implementing an approved Work Request. If the Work Request results in a change in the then Unit Sale Price as agreed by both parties, once the change
has been implemented, all subsequent invoices issued by KMC will reflect the amended Unit Sale Price. 
  

	 	10.	INVOICING 

 10.1
Invoicing. KMC shall invoice LipoScience for the Instruments manufactured hereunder upon successfully completing the ATP, at the then Unit Sale Price. 
 10.2 Security. (i) No later than the twentieth (20th) of each month commencing on the Effective Date of this Agreement, LipoScience shall provide KMC with copies of the following
unaudited LipoScience financial documents (collectively, the “Statements”): 
 (a) income statements; 

(b) balance sheet; and 
 (c) cash flow statement. 

  
 7 

 Each monthly set of Statements shall be provided with a report reflecting results of LipoScience’s
operations for the previous month and summary year-to-date results, as applicable for each Statement. 
 In the event, in
KMC’s reasonable discretion, LipoScience’s unrestricted cash balance (which cash balance may include readily marketable securities) for the preceding month is less than four million dollars ($4,000,000.00), LipoScience shall immediately
deposit (without KMC being required to take any action demanding such deposit) the Materials Commitment Amount. The “Material Commitment Amount” will be the monetary total of all material commitments or orders that KMC has placed
with respect to the Instrument to date (excluding any amounts already paid by LipoScience to date) plus fifteen percent (15%) of such amount. Such Material Commitment Amount shall be deposited in immediately available funds to the bank indicated by
KMC for payment below. Immediately after the occurrence of such event, all KMC invoices shall be due in full (except for amounts disputed in good faith), within [***] days of the date of such invoices. 

 

			
	Deposit Bank:	  	Bank of America
		  	P.O. Box 4850
		  	Boston, MA 02212-4850

 If LipoScience fails to promptly comply with any obligation under these Sections 10.2 and/or 10.3, KMC
shall provide [***] calendar day’s written notice to LipoScience of such failure to comply, and LipoScience shall fully comply within such [***] days notice. If LipoScience fails to comply within such [***] day period, such compliance shall be
deemed a material breach of this Agreement, and, without limiting any of KMC’s other rights and remedies, KMC shall not be obligated to provide any further services under this Agreement until LipoScience shall have complied in full. 

(ii) LipoScience represents to KMC that the Statements to be provided to KMC in accordance with the requirements of Section 10.2(i)
will fairly present the financial condition and results of operations and cash flow of LipoScience as at the respective dates of and for the periods referred to in such Statements, all in accordance with GAAP; the Statements will reflect the
consistent application of such accounting principles throughout the periods involved; and, to the extent for any period (monthly or year to date) set forth in Section 10.2(i) LipoScience provides financial statements to its investors, such
Statements provided to KMC shall be the same financial statements provided to its investors. 
 10.3 Payment. All
undisputed items on an invoice shall be paid by LipoScience, in full, within [***] calendar days of the date of invoice. Failure to make full payment of such undisputed items on KMC invoices within the [***] day period provided in this Agreement
[***] shall constitute a material breach by LipoScience [***]. Furthermore, KMC may assess LipoScience interest at the rate of one and one-half percent (1 l/2%) per month or the maximum rate allowed by applicable law, whichever is lower, on any past
due amount, together with its costs of collection (including, without limitation, attorneys’ fees and expenses). All invoices shall be payable to KMC in Dollars to a bank in the United States designated by KMC. 

10.4 Disputed Invoices. In the event LipoScience desires to dispute in good faith any invoice, or item under any invoice,
LipoScience will, within fifteen (15) days of the receipt of the given invoice, provide KMC with a written notice setting forth the details of the disputed invoice or item and the amount in question. LipoScience will timely pay to KMC the

  
 [***] = Certain information on this page, marked
by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  
 8 

 
amount of any such invoice not in dispute. The parties will work together, in good faith, to resolve such dispute within thirty (30) days after such notice of dispute is sent.
LipoScience’s failure to pay an invoice or item of an invoice that it disputes in good faith shall not constitute a material breach under this Agreement. If, notwithstanding such efforts, the parties are unable to resolve a dispute within
[***], the parties shall submit the dispute to binding arbitration before a single arbitrator mutually agreeable to the parties (provided, however, that if the parties are unable to mutually agree upon such an arbitrator within [***] calendar days
of the commencement of an arbitration proceeding, then such arbitrator shall be selected by the American Arbitration Association in accordance with its then prevailing rules), which arbitration shall be conducted in accordance with the commercial
arbitration rules of the American Arbitration Association, to be held in the AAA’s offices in [***]. The fees and expenses of the arbitrator shall be borne by [***]. In the event the parties have not resolved such dispute within [***] calendar
days after LipoScience has provided such notice of dispute, [***]. 
 10.5 Taxes. LipoScience shall pay all taxes, fees
and duties or other amounts, however designated, including any value added taxes, which are levied or based upon the fees and other amounts charged by KMC to LipoScience under this Agreement; provided that the foregoing shall not obligate
LipoScience to pay any taxes based on the income, gross receipts or property of KMC. 
 10.6 Reimbursement of Travel
Expenses. Upon prior written request by KMC, and approval in writing by LipoScience, LipoScience shall reimburse KMC for all reasonable travel and related expenses incurred by KMC in connection with the performance of this Agreement. KMC shall
provide receipts and/or other reasonable documentation of all such expenses. 
 10.7 Financial Audits Rights. During the
Term of this Agreement and for a period of three (3) years thereafter, upon five (5) Business Days’ prior written notice to KMC, LipoScience may, at its expense, audit through a third party accounting firm, KMC’s financial
records relating to the performance of this Agreement (which records will be kept by KMC for three (3) years following termination of this Agreement), as reasonably deemed necessary by LipoScience to confirm the amounts payable by LipoScience
hereunder. Any such audit will be performed during KMC’s normal business hours; and LipoScience shall use its reasonable efforts not to disrupt KMC’s business operations during such audit. Audits may be conducted pursuant to this Section
no more than two (2) times in any consecutive twelve (12) month period. In the event LipoScience does request an audit pursuant to this Section, the parties shall mutually agree on the third party accounting firm to conduct such audit. The
accounting firm mutually agreed to by the parties shall be required to sign a non-disclosure agreement with KMC prior to conducting any such audit. The cost of any such audit shall be borne by LipoScience, provided, however, that if, such audit
reveals an overpayment of five percent (5%) or more of the amount that should have been paid for the period(s) audited, then KMC shall bear the expense of the audit, and shall promptly refund to LipoScience any amounts overpaid by LipoScience.

  
 [***] = Certain information on this page, marked
by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  
 9 

	 	11.	SHIPMENT & TRANSPORTATION 

 11.1 F.C.A. Point. All prices are F.C.A. (Incoterms 2000) KMC’s plant. LipoScience shall be responsible for the payment of all transportation charges incurred in connection with this
Agreement. 
 11.2 Shipping Instructions. KMC will ship in accordance with LipoScience’s written shipping
instructions, including, LipoScience’s specified mode of transportation and carrier, and if requested by LipoScience, drop shipments to its designated customers. KMC shall pack and ship the Instruments in such containers and packaging and
labeling as set forth in written instructions from LipoScience. In the absence of specific written shipping instructions, KMC reserves the right to ship by the method it, in good faith, deems most appropriate to the LipoScience facility, but KMC
shall provide LipoScience with at least five (5) Business Days’ written notice of its intent to ship the Instruments in the manner it deems most appropriate prior to actual shipment thereof. 

11.3 Damage Claims. All claims for loss or breakage and damage, whether concealed or obvious, must be made to the carrier by
LipoScience within a reasonable time after receipt of the shipment, but in no event shall KMC be responsible for any such loss, breakage or damage, unless due to KMC’s negligence or willful misconduct, or KMC’s failure to adhere to any
specific packing or shipping instructions provided by LipoScience. 
  

	 	12.	WARRANTY OF KMC 

 12.1
Warranty. KMC warrants to LipoScience that the Instruments manufactured hereunder will be free, under normal use and maintenance, from defects in KMC material and workmanship (the “KMC Warranty”) for [***] (the
“Warranty Period”). KMC shall have no liability under the KMC Warranty for claims arising (in whole or in part) from any of the following: incorrect use, misuse, faulty maintenance, or improper storage of an Instrument. The KMC
Warranty specifically excludes: any materials provided by LipoScience from a third party vendor (a “LipoScience Vendor”), customer furnished, or customer directed materials from a supplier not approved by KMC’s quality
organization, unless such materials have been damaged or mishandled by KMC in the manufacturing process. The KMC Warranty is voided with respect to any Instrument that has been altered, repaired (successfully or not) or had parts replacement by any
party other than KMC, LipoScience or a KMC or LipoScience trained service representative. The KMC Warranty does not cover damages due to fire, explosion, power irregularities, power surges, acts of God or nature, including earthquakes, rain, floods
or lightening, or any other cause not wholly and directly attributable to KMC. 
 12.2 LipoScience Software. The parties
acknowledge and agree that the KMC Warranty specifically excludes any and all liability with respect to any LipoScience Software, regardless of the fact that such software may be incorporated into the Instrument, and/or such software’s
functionality within the Instrument. 
 12.3 Repair or Replace. As LipoScience’s sole and exclusive remedy for any
breaches of the KMC Warranty, KMC will, at KMC’s option, repair or replace without charge, 
  
 [***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 10 

 
any Instrument manufactured by it, which is found by KMC to be so defective; provided, however, that (a) the Instrument is returned in accordance with KMC’s Return
Material Authorization (“RMA”) process, (b) the Instrument, subassembly or component involved is returned by transportation designated by KMC to a location designated by KMC, and at the cost of KMC, and (c) KMC is notified
by LipoScience in writing of the defect within thirty (30) days of the expiration of the Warranty Period set forth in Section 12.1 hereof. 
 12.4 Disclaimer. OTHER THAN THE KMC WARRANTY SPECIFIED IN SECTION 12.1 ABOVE, KMC MAKES NO OTHER WARRANTIES OF ANY KIND WHATSOEVER, EXPRESS OR IMPLIED, WITH RESPECT TO THE INSTRUMENT,
GOODS OR SERVICES TO BE PROVIDED HEREUNDER, AND ALL WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE HEREBY EXPRESSLY DISCLAIMED BY KMC AND EXCLUDED FROM THE TERMS OF THIS AGREEMENT. 

 

	 	13.	TERM AND TERMINATION 

13.1 Term of Agreement. This Agreement will commence as of the Effective Date and, unless sooner terminated as herein provided,
will continue in effect for a period of three (3) years commencing on the date of KMC’s shipment hereunder of the first unit of the Instrument or delivery of the thirtieth (30) unit of the Instrument, whichever is later (the “Initial
Term”). The Initial Term shall automatically extend for additional one (1) year periods unless either party provides the other party with written notice of termination not later than ninety (90) calendar days prior the end of the Initial
Term or any such one (1) year extension. 
 13.2 Termination by Either Party. This Agreement may be terminated at any
time by notice in writing to the other party upon the occurrence of one or more of the following events: 
 (a)
In the event of a material breach hereunder, then the non-breaching party may terminate this Agreement upon not less than [***] calendar days prior written notice, setting forth the alleged breach, unless the breach is cured prior to the expiration
of such notice period. 
 (b) In the event that LipoScience permanently discontinues the marketing of the
Instrument, LipoScience shall have the right to terminate this Agreement upon not less than [***] calendar days prior written notice to KMC; provided, however, if production of the Instrument, or marketing, distribution or sale of the
Instrument, is reinstated by LipoScience within [***] months thereafter, LipoScience shall provide KMC with written notice of such determination and KMC shall have the option and right to have this Agreement reinstated. If KMC shall elect to so
reinstate this Agreement after such termination, then the Term shall automatically be extended by the amount of time for which this Agreement was terminated. 
 (c) If either party shall file a petition in bankruptcy, or shall be adjudicated bankrupt, or shall take advantage of the insolvency law of any state or country, or shall make an assignment for the
benefit of creditors, or shall have a receiver, trustee or other court officer appointed for its property, then the other party may terminate this Agreement upon written notice to the other. 
  
 [***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the
Securities and 
 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 11 

  

 13.3 Termination by Either Party Upon a Change of Control. In the event that
either KMC or LipoScience experiences a Change of Control (as hereinafter defined) during the Term of this Agreement, then either party may, within [***] days of such Change of Control (and upon [***] written notice to the other party), terminate
this Agreement, whereupon there shall be no further obligations of either party to the other (except that the provisions set forth in Section 35 shall survive). For purposes of this Agreement, a “Change of Control” is defined
to mean a merger, consolidation, corporate reorganization or any transaction in which all or substantially all of the assets or stock of KMC or LipoScience are sold, leased, transferred or otherwise disposed of (other than a mere reincorporation
transaction or one in which the holders of capital stock of KMC or LipoScience immediately prior to such merger, consolidation, corporate reorganization or transaction continue to hold at least a majority of the voting power of the surviving
corporation). 
 13.4 Termination by KMC. In the event KMC’s production activities under a Purchase Order are
interrupted and/or delayed due to the request of LipoScience, or the failure of LipoScience to perform its obligations under this Agreement, for any continuous period in excess of [***] calendar days, then KMC shall have the right to terminate this
Agreement upon [***] days’ written notice to LipoScience. 
 13.5 Obligations Upon Termination. 

(a) Neither termination nor expiration of this Agreement shall release any party from fulfilling any obligations which it may have
incurred prior to any such termination or expiration. In the event of any termination of this Agreement, unless otherwise directed by LipoScience (in the event of termination hereunder by LipoScience) or unless such termination is by KMC pursuant to
Section 13.2(a) hereof, KMC will complete the outstanding Purchase Order activity. 
 (b) In addition to any other amounts
due under this Agreement, LipoScience shall pay KMC for all reasonable expenses incurred by KMC in performance of this Agreement due to non-cancelable material and labor commitments made by KMC prior to receipt by KMC of a written notice of
termination from LipoScience or KMC’s issuance of a written notice of termination to LipoScience, provided that KMC shall provide to LipoScience all receipts, invoices and other reasonable evidence of such costs and expenses as reasonably
requested by LipoScience. These expenses may include, but are not limited to, completed but uncompensated production labor hours expended, inventory and work-in-process, and materials ordered and not returnable or subject to cancellation, actual
cancellation charges, restocking fees and other similar charges incurred by KMC, all to the extent that such costs and expenses are consistent with the Purchase Commitment provided to KMC and at KMC’s then current sell rates less advance
payments, if any, made by LipoScience to KMC toward such expenses. KMC will use reasonable efforts to minimize such termination expenses. 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 12 

 (c) If LipoScience terminates this Agreement as a result of a breach by KMC of any of
Sections 2, 3.2, 5.1 or 5.2 of this Agreement, then KMC shall, at KMC’s own expense, cooperate with the transfer of the TDP and any LipoScience Work Product and specific know-how related to the manufacture of the Instruments to
LipoScience’s new manufacturing partner. Any such cooperation by KMC shall be subject first to any new manufacturing partner entering into a reasonable confidential nondisclosure agreement with KMC with respect to KMC’s confidential and
proprietary information. The rights of LipoScience set forth in the Section shall be in addition to any other rights and privileges that LipoScience may be entitled to under law or equity. 

(d) Upon any termination or expiration of this Agreement, KMC shall promptly deliver to LipoScience the TDP, such other materials paid
for by LipoScience, unless LipoScience requests that any such materials be destroyed, and any specific know-how related to the manufacture of the Instruments to LipoScience’s new manufacturing partner, at LipoScience’s expense. 

 

	 	14.	INTELLECTUAL PROPERTY 

14.1 No New Work Product or Intellectual Property. The parties agree that no Intellectual Property is expected to be developed
under this Agreement. All Work Product owned by LipoScience pursuant to the terms of the Development Agreement shall remain the Work Product of LipoScience, and all Work Product owned by KMC pursuant to the terms of the Development Agreement shall
remain the Work Product of KMC. Each of the parties respective other Intellectual Property shall remain its own property, and except as set forth in Section 15 below, nothing in this Agreement shall be construed as granting any license or
assignment, by implication, estoppel or otherwise, to either party to make, have made, use, or sell any Intellectual Property of the other party. In the event that any new Intellectual Property is developed with respect to the Instrument by KMC
during the performance of its services under this Agreement, KMC agrees to assign such intellectual property rights in and to such Intellectual Property to LipoScience, and agrees to cooperate at LipoScience’s expense in LipoScience’s
efforts to effect, perfect, maintain and evidence such assignment. 
  

	 	15.	INFRINGEMENT 

 15.1
Grant of Limited License. LipoScience grants KMC a limited, revocable, non-exclusive, non-transferable, and non-sublicenseable license, under which KMC may use the Marks solely in connection with KMC’s production of the Instruments and
the labels and packaging therefor. LipoScience reserves all rights in the Marks not expressly granted in this Agreement. 
 15.2
Infringement. Except with respect to the [***], LipoScience represents and warrants that neither it, nor any third parties retained by it in connection herewith (excluding KMC) shall provide any materials, components, designs, trademarks,
trade names, logos, information or documentation to be used or incorporated into the Instruments that violate the patent, copyrights, trade secrets or other personal or proprietary rights of a third party. Except with respect to the [***],
LipoScience represents and warrants to KMC that it is the sole and 
  
 [***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 13 

 
exclusive owner of, and has the sole and exclusive right to license, all the Marks as licensed hereunder and has obtained all permissions necessary for KMC to lawfully perform its obligations
under this Agreement with respect to the Marks. 
 15.3 [***]. In addition to the indemnification obligations of LipoScience in
Section 18.1 below, LipoScience agrees to indemnify, defend and hold harmless KMC, its Affiliates, and their officers, directors, employees, and agents (the [***]) from and against any and all losses, costs, damages, liabilities and expenses of
any kind whatsoever payable to third parties (including all reasonable attorneys’ fees and court costs) incurred by the [***] in connection with any and all suits, investigations, claims or demands of third parties (collectively, the [***])
with respect to the [***]. In the event any [***] is asserted against a [***] for which LipoScience may be required to indemnify such [***] under this provision, KMC shall give LipoScience prompt written notice of same. KMC shall cooperate with
LipoScience, upon LipoScience’s reasonable request and at LipoScience’s cost and expense, in the defense of any such Claim. LipoScience shall have the sole right to defend and/or settle such a Claim, including selecting counsel of its
choice, reasonably acceptable to KMC, provided that, in the event of settlement, the settlement is for monetary damages only and is conditioned upon a full and unconditional release of the [***]. 

 

	 	16.	NON-SOLICITATION 

 During
the Term and for a period of [***] thereafter, neither KMC nor LipoScience shall solicit directly or indirectly (whether for its own account or for the account of any other person or entity) for employment any employees of the other. The parties
acknowledge and agree that nothing herein shall prohibit a party from hiring anyone who responds to an employment advertisement placed in a publication of general circulation, including, without limitation, the internet. 

 

	 	17.	INSURANCE COVERAGE 

 17.1
Insurance Obligation of KMC. KMC maintains, and shall maintain in good standing throughout the Term, comprehensive general liability insurance in an amount of at least $[***] per occurrence and in the aggregate. Upon written request by
LipoScience, KMC shall deliver to LipoScience a certificate of insurance verifying such insurance coverage. 
 17.2 Insurance
Obligation of LipoScience. LipoScience maintains, and shall maintain in good standing throughout the Term, comprehensive general liability insurance in an amount of at least $[***] per occurrence and in the aggregate. Upon written request by
KMC, LipoScience shall deliver to KMC a certificate of insurance verifying such insurance coverage. 
  

	 	18.	INDEMNITY 

 18.1 By
LipoScience. (a) LipoScience agrees to indemnify, defend and hold harmless KMC and its officers, directors, employees, customers, distributors and agents (the “KMC Indemnified Parties”) from and against any and all losses,
costs, damages, liabilities and expenses of any kind whatsoever claimed by and payable to third parties (including all 
  

[***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 14 

 
reasonable attorneys’ fees and court costs) (collectively, “Damages”) incurred by the KMC Indemnified Parties in connection with any and all suits, investigations, claims or
demands of third parties (collectively, “Claims”) arising from any Instrument or the services provided by KMC hereunder, except to the extent that same results from the negligence, negligent omission or willful misconduct of KMC, or the
breach of this Agreement by KMC. In the event any Claim is asserted or filed against a KMC Indemnified Party for which LipoScience may be required to indemnify such KMC Indemnified Party under this provision, KMC shall give LipoScience prompt
written notice of same. KMC shall cooperate with LipoScience, upon LipoScience’s reasonable request and at LipoScience’s cost and expense, in the defense of any such claim. LipoScience shall have the sole right to defend and/or settle such
a claim, including selecting counsel of its choice, reasonably acceptable to KMC, provided that KMC shall not be bound by any settlement or compromise of any Claim without its prior written consent. 

18.2 By KMC. KMC agrees to indemnify, defend and hold harmless LipoScience and its officers, directors, employees, customers,
distributors and agents (the “LipoScience Indemnified Parties”) from and against any and all Damages incurred by the LipoScience Indemnified Parties in connection with any and all Claims arising out of or in any way connected with or the
production services provided by KMC hereunder, provided the same results from the negligence, negligent omission or willful misconduct of KMC, or the breach of this Agreement by KMC. In the event any Claim is asserted or filed against any
LipoScience Indemnitee for which KMC may be required to indemnify LipoScience under this provision, LipoScience shall give KMC prompt written notice of same and shall cooperate with KMC, upon KMC’s reasonable request and at KMC’s cost and
expense, in the defense of any such claim. KMC shall have the sole right to defend and/or settle such a claim, including selecting counsel of its choice, reasonably acceptable to LipoScience, provided that LipoScience shall not be bound by any
settlement or compromise of any Claim without its prior written consent. 
  

	 	19.	LIMITATION OF LIABILITY 

19.1 WAIVER OF DAMAGES, LIMITATION ON LIABILITY. [***], NEITHER LIPOSCIENCE NOR KMC SHALL BE LIABLE IN CONTRACT,
TORT OR OTHERWISE, TO THE OTHER FOR ANY INCIDENTAL, CONSEQUENTIAL, INDIRECT, EXEMPLARY, PUNITIVE OR SPECIAL DAMAGES OF ANY KIND OR NATURE, INCLUDING WITHOUT LIMITATION, LOST REVENUES, LOST PROFITS, DELAY OR LOSS OF BUSINESS ARISING OUT OF OR
RELATING TO THIS AGREEMENT OR THE BREACH THEREOF, WHETHER OR NOT LIPOSCIENCE OR KMC WAS ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. EXCEPT WITH RESPECT TO LIPOSCIENCE’S OBLIGATIONS UNDER SECTION 15.3, NEITHER PARTY’S LIABILITY ON ANY CLAIM
OF ANY KIND, INCLUDING NEGLIGENCE, FOR ANY LOSS OR DAMAGE ARISING OUT OF, CONNECTED WITH, OR RESULTING FROM THIS AGREEMENT OR PERFORMANCE OR BREACH THEREOF, SHALL IN ANY SINGLE CASE, OR IN THE AGGREGATE, EXCEED [***]. IF THE AMOUNTS PAID BY
LIPOSCIENCE TO KMC DURING THE TERM OF THIS AGREEMENT ARE [***], THE LIMITATION OF LIABILITY SET FORTH IN THE PRECEDING SENTENCE SHALL BE [***] IN THE AMOUNT [***]  
  
 [***] = Certain information on this page, marked by brackets, has been omitted and filed separately with the
Securities and 
 Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  
 15 

 
BY [***] TO [***]. EACH PARTY ACKNOWLEDGES AND AGREES THAT THE FOREGOING LIMITATIONS ON LIABILITY ARE ESSENTIAL ELEMENTS OF THE BASIS OF THE BARGAIN BETWEEN THE PARTIES AND THAT IN
THE ABSENCE OF SUCH LIMITATIONS, THE MATERIAL AND ECONOMIC TERMS OF THIS AGREEMENT WOULD BE SUBSTANTIALLY DIFFERENT. 
  

	 	20.	FORCE MAJEURE 

 Neither
party shall be deemed in default of this Agreement to the extent that performance of its obligations (except for payment obligations), or attempts to cure any breach are delayed or prevented by acts or occurrences beyond the reasonable control of
such party, including without limitation acts of civil or military authorities, any law, order, direction, regulation, ordinance, action, of any governmental authority, embargoes, epidemics, fires, flood, tornadoes, hurricanes, earthquakes,
unusually severe weather conditions, volcanic action, storm, other environmental disturbances, wars, riots, insurrections, civil disturbances, explosions, nuclear accidents, threats or acts of terrorism or similar acts, electrical power surges or
failures, work stoppages or slow downs, acts of God, vandalism, other similar catastrophe; national emergencies, strikes, lockouts, inability to secure products or services of other persons, curtailment of transportation facilities, acts of
transportation carriers, governmental travel advisories or prohibitions, (individually or collectively, a “Force Majeure”), provided that such failure to perform is not caused by the negligence or willful act(s) of the
non-performing party and provided that the party whose performance will be delayed by such events will use (i) its reasonable efforts to notify the other promptly of its becoming aware of the occurrence of such an event, and (ii) all
reasonable efforts to continue to so perform or cure. Such party whose performance has been delayed by an event of force majeure will also provide prompt notice to the other party of the cessation of such event. 

 

	 	21.	ASSIGNMENT 

 This
Agreement shall inure to the benefit of and bind the parties and their respective successors and permitted assigns; provided however, neither party shall have the right to transfer or assign this Agreement or its rights and obligations under this
Agreement to any third party without the other party’s prior written consent, such consent not to be unreasonably withheld or delayed, except that either party may, without the other party’s consent, assign or transfer this Agreement or
any rights hereunder to an entity with which such party engages in a Change of Control transaction. Notwithstanding the foregoing, each party shall nonetheless have the right to terminate this Agreement in the event of a Change of Control pursuant
to the terms and conditions set forth in Section 13.3 herein. 
  

	 	22.	AMENDMENTS 

 No provision
of this Agreement may be amended, modified or otherwise changed, other than by an instrument in writing duly executed on behalf of the parties to this Agreement. 

 
 [***] = Certain information on this page, marked by brackets,
has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  
 16 

	 	23.	ENTIRE AGREEMENT 

 The
Development Agreement, this Agreement and its Attachments, constitute the entire understanding between the parties with respect to the subject matter hereof, and shall supersede and nullify all prior or contemporaneous agreements, whether written or
oral, relating thereto; provided, however, that the parties shall continue to be bound under that certain Mutual Nondisclosure Agreement (the “NDA”) executed by the parties, dated as of November 1, 2004, which continues to be
in full force and effect in accordance with its terms except that its term is hereby amended to be concurrent with the term and any termination of this Agreement. 
  

	 	24.	NOTICES 

 All notices,
demands and requests or other documents to be given hereunder shall be in writing and shall be deemed to have been given for all purposes (a) upon personal delivery, (b) one (1) day after being sent, when sent by professional
overnight courier service from and to locations within the continental United States, (c) five (5) days after posting when sent by registered or certified mail, addressed as set forth below or (d) when sent, if sent by facsimile,
provided that the receipt of successful facsimile transmission is received by the sender and, in each case, addressed to the party at the following address for such party or such other address as is provided by a party to the other in accordance
with this Article: 
  

			
	For LipoScience:	  	LipoScience, Inc.
		  	2500 Sumner Boulevard
		  	Raleigh, NC 27616
		  	Attention: President
		  	Fax No.: [***]
		
	With a copy to:	  	
		  	LipoScience, Inc.
		  	Attention: General Counsel
		  	2500 Sumner Boulevard
		  	Raleigh, NC 27616
		  	Fax No.: [***]
	For KMC:	  	
		  	KMC Systems, Inc.
		  	220 Daniel Webster Highway
		  	Merrimack, NH 03054
		  	Attention: President
		  	Fax No.: [***]
		
	With a copy to:	  	
		  	KMC Systems, Inc.
		  	220 Daniel Webster Highway
		  	Merrimack, New Hampshire 03054
		  	Attention: General Counsel
		  	Fax No.: [***]

  
 [***] = Certain information on
this page, marked by brackets, has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential
treatment has been requested with respect to the omitted portions. 

  
 17 

	 	25.	GOVERNING LAW 

 This
Agreement shall be governed by and construed in accordance with the laws of the State of Delaware applicable to contracts made in and entirely performed in such State, and, therefore, without regard to conflict of laws principles. The parties
acknowledge and agree that the Uniform Computer Information Transaction Act and the United Nations Convention on Contracts for the International Sale of Goods do not and will not apply to this Agreement or the transactions contemplated herein.

  

	 	26.	EMPLOYEES 

 Each
party’s personnel shall serve under the exclusive direction and control of that party and shall not be deemed to be employees or agents of the other party. Each party shall be solely responsible for payments of all such personnel’s
compensation, including wages, benefits, taxes, workers’ compensation, disability, and other insurance and the withholding or deduction of such items to the extent required by applicable law. 

 

	 	27.	RELATIONSHIP OF PARTIES 

The parties to this Agreement are independent contractors and not joint venturers or partners. Neither party shall be deemed to be an
agent of the other party as a result of any transaction under or related to this Agreement. 
  

	 	28.	COMPLIANCE WITH LAWS; ANTI-TERRORISM AND ANTI-CORRUPTION 

 In their performance of this Agreement, the parties shall comply with the provisions of all applicable federal, state, county, and local laws, ordinances, regulations and codes (including procurement of
required permits, licenses or certificates), including, without limitation: 
 (i) laws governing the making of improper
payments; 
 (ii) United States and non-United States export control laws; 

(iii) the United States Foreign Corrupt Practices Act; and 
 (iv) the United States Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism (USA Patriot Act) Act of 2001 and U.S. Executive Order 13224.

 The parties agree to notify the other immediately in writing in the event that any of the covenants in this Section cease to
be accurate. Each party agrees to indemnify the other party for, defend against, and hold harmless from, any loss or damage sustained because of the other party’s noncompliance under this Section. 

  
 18 

	 	29.	COMPLIANCE WITH FACILITY RULES 

 The respective agents and employees of the parties, while on the premises of the other, shall comply with all facility rules, regulations and reasonable company standards for security. 

 

	 	30.	WAIVER 

 The failure of
either party to insist upon strict compliance with any of the terms, covenants, or conditions herein shall not be deemed a waiver by such party of such terms, covenants or conditions, nor shall any waiver or relinquishment of any right at any one or
more times be deemed a waiver or relinquishment of such right at any other times, nor shall any single or partial exercise of any right or remedy hereunder preclude any other or a future exercise thereof or the exercise of any other right or remedy
granted hereby or by any related document or by law. 
  

	 	31.	SEVERABILITY 

 The
invalidity or unenforceability of any provision hereof shall in no way affect the validity or enforceability of any other provision. Any provision declared invalid or unenforceable by a court of competent jurisdiction shall be deemed to be
automatically amended and replaced by a valid and enforceable provision that accomplishes, to the greatest extent possible, the purpose and intent of the original provision, and the remaining terms and conditions of this Agreement shall remain in
full force and effect. 
  

	 	32.	FEES AND EXPENSES 

 Except
as otherwise provided in this Agreement, each of the parties hereto shall pay its own fees and expenses (including, without limitation, the fees of any attorneys, accountants, investment bankers or other representatives and travel expenses) incurred
in connection with this Agreement and the transactions contemplated hereunder, whether or not such transactions are consummated. 
  

	 	33.	CONSTRUCTION 

 The parties
have jointly prepared this Agreement, and it may not be strictly construed against either party. 
  

	 	34.	COUNTERPARTS 

 This
Agreement may be fully executed in one (1) or more counterparts, all of which shall be deemed an original, and taken together shall constitute one and the same instrument. 

 

	 	35.	SURVIVAL 

 Notwithstanding
any termination or expiration of this Agreement, the following sections shall survive: Section 10.7 (Financial Audit Rights – for the period contemplated in such Section), Article 12 (Warranty of KMC – for the period contemplated in
such Article), Section 

  
 19 

 
13.5 (Obligations upon Termination), Article 14 (Intellectual Property), Article 15 (Infringement), Article 16 (Non-Solicitation), Article 18 (Indemnification), Article 19 (Limitation of
Liability), Article 25 (Choice of Law), and Article 35 (Survival). 
 [remainder of page intentionally blank; signature page
follows] 

  
 20 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first
above written. 
  

			
	LIPOSCIENCE, INC., a Delaware corporation
		
	By:	 	 /s/ Lucy G. Martindale

	Name:       Lucy G. Martindale
	Title:      CFO

 
			
	
	KMC SYSTEMS, INC., a Delaware corporation
		
	By:	 	 /s/ Patrick W. McNallen

		 	   Patrick W. McNallen
   President

  

 LIST OF APPENDICES 

 

					
	APPENDIX I	 	Elements of Instruments	 	

 LIST OF SCHEDULES 

 

					
	SCHEDULE 1	 	Material Lead Times	 	
			
	SCHEDULE 2	 	Pricing Formula; Unit Sale Price	 	

  

 *** Text Omitted and Filed Separately 

Confidential Treatment Requested 
 Under 17 CFR §§ 200.80(b)(4) and 230.406 
  

 APPENDIX I 
 TO 
 PRODUCTION AGREEMENT 

Elements of Instruments 
 The LipoScience Numera Analyzer is a multi-assay, clinical laboratory instrument that employs nuclear magnetic resonance spectroscopic detection to quantify multiple analyses in biological fluid
specimens, specifically blood plasma and serum. The current configuration of the Numera Instrument provides a diagnostic evaluation of a patient’s risk for cardiovascular disease and related maladies. This is done by detecting the response of a
patient’s blood sample when placed in a magnetic field and exposed to radio frequency pulses. The resulting NMR LipoProfile provides an improved diagnostic result over traditional Total Cholesterol, HDL, LDL and Triglyceride
measurements. The instrument shall contain features intended to support additional NMR assays as they are developed. 
 The NMR System, Part
Number [***] is partitioned into four major components: 
  

	 	1)	MAGNET, VARIAN NMR, [***] MHZ, [***] MM BORE 

  

	 	2)	ASSY, N.M.R. PROBE 

  

	 	3)	ASSY, CONSOLE (VARIAN) 

  

	 	4)	ASSY, Sample Manager WITHOUT PANELS 

 The table
below denotes the activity and responsibility for supply, assembly and test. 
  

									
	Item	 	Description	  	Qty	  	UOM	  	Activity and Responsibility
	[***]	 	ASSY, TOP, NUMERA SYSTEM	  	1	  	EA	  	Built, integrated and tested at System level at KMC
		 	KMC Systems	  		  		  	
	[***]	 	ASSY, Sample Manager WITHOUT PANELS	  	1	  	EA	  	Sample Manager built, integrated and tested at System level at KMC
	[***]	 	ASSY, MAGNET COVERS	  	1	  	EA	  	Built, integrated and tested at System level at KMC Ordered, and shipped to customer site by
	[***]	 	UPS (MV-GT-3208T)	  	0	  	EA	  	LipoScience as required
		 	Varian, LipoScience	  		  		  	
	[***]	 	ASSY, CONSOLE (VARIAN)	  	1	  	EA	  	Supplied by Varian to KMC, built, integrated and tested at System level by KMC
	[***]	 	ASSY, N.M.R, PROBE	  	1	  	EA	  	Supplied by Varian to LipoScience, Reworked @ LipoScience, Supplied to KMC for Integration and testing at System level
	[***]	 	MAGNET, VARIAN NMR, [***] MHZ, [***] MM BORE	  	0	  	EA	  	Supplied by Varian, shipped directly to customer site
	[***]	 	SHIP KIT, ANALYTICAL CONSOLE, [***] MHZ	  	1	  	EA	  	Supplied by Varian to KMC for partial use in construction of Numera System, balance of material shipped with System
	[***]	 	SYSTEM INTERCONNECT, [***] MR	  	0	  	EA	  	Supplied by Varian, reference document for customer site
	[***]	 	CRYOGEN MONITOR	  	1	  	EA	  	Supplied by Varian to KMC, Integrated and tested at system level by KMC
	Misc Material shipped with System for Site Installation
	[***]	 	ASSY, CABLE [***] VAC POWER	  	1	  	EA	  	Supplied by KMC
	[***]	 	CPLG, PUSH TO CONNECT, [***] “X [***]” OD, GRAY	  	1	  	EA	  	Supplied by KMC
	[***]	 	CPLG, PUSH TO CONNECT, ELBOW, [***] OD, GRAY INLINE FILTER, [***] TUBE ID, [***] MICRON [***] “ODX [***]”L	  	1	  	EA	  	Supplied by KMC
	[***]	 	CLEAR	  	1	  	EA	  	Supplied by KMC
	[***]	 	TUBING, PUN-6X1-BL	  	17	  	FT	  	Supplied by KMC
	[***]	 	CPLG, PUSH-TO CONNECT, [***] TUBE , GRAY	  	1	  	EA	  	Supplied by KMC
	[***]	 	CABLE TIE MOUNT	  	2	  	EA	  	Supplied by KMC
	[***]	 	TIE, CABLE, LKG, [***]”L	  	2	  	EA	  	Supplied by KMC
	[***]	 	WIRETIE, NYLON, [***]L,0. [***]W	  	1	  	EA	  	Supplied by KMC

  
 [***] = Certain information on
this page has been omitted and filed separately with the Securities and 
 Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions. 

  

 *** Text Omitted and Filed Separately 

Confidential Treatment Requested 
 Under 17 CFR §§ 200.80(b)(4) and 230.406 
  

 SCHEDULE 1 
 TO 
 PRODUCTION AGREEMENT 

Material Lead Times 
 [***] 
  

[***] = Certain information on this page has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 

  

 *** Text Omitted and Filed Separately 

Confidential Treatment Requested 
 Under 17 CFR §§ 200.80(b)(4) and 230.406 
  

 SCHEDULE 2 
 TO 
 PRODUCTION AGREEMENT 

Pricing Formula; Unit Sale Price 
 The following formula will be used for calculation of the Unit Sale Price to LipoScience: 
 Material Cost = Total Raw Material Cost multiplied by [***] 
 Labor Cost = Total
Direct Labor Cost multiplied by [***] 
 Total Cost = (Material Cost plus Labor Cost) multiplied by [***] 

Unit Sale Price = Total Cost multiplied by [***] 
 For illustrative purposes, the following is an example of the application of the foregoing formula that is based on data from Schedule 1 on the date hereof: 

Instrument Unit Build 

							
	 	  	Purchase Order Quantity
	 	  	[***]	 	[***]	 	[***]
	 Total Raw Material Cost
	  	[***]	 	[***]	 	[***]
	 Total Material Cost = Total Raw Material Cost x [***]
	  	[***]	 	[***]	 	[***]
				
	 Total Direct Labor Cost
	  	[***]	 	[***]	 	[***]
	 Total Labor Cost = Total Direct Labor Cost x [***]
	  	[***]	 	[***]	 	[***]
				
	 Total Cost = (Total Material Cost + Total Labor Cost) x [***]
	  	[***]	 	[***]	 	[***]
				
	 Unit Sale Price = Total Cost x [***]
	  	[***]	 	[***]	 	[***]

 Assumptions: 

	1.	Based on released BOM as of April 30, 2009, as further described on Schedule 1 

	2.	Labor Cost is based on anticipated direct labor rates for 2010 

  

[***] = Certain information on this page has been omitted and filed separately with the Securities and 

Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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