Document:

EXHIBIT 10.10

                               DELTA MUTUAL, INC.
                             111 North Branch Street
                             Sellersville, PA 18960

July 1, 2003

Gary T. Robinson
162 West 54th Street, Suite 12-E
New York, New York 10019

Dear Mr. Robinson:

This shall serve as the agreement by and between Delta Mutual, Inc., a Delaware
Corporation (the "Company") and Gary T. Robinson of New York, (the "Employee")
to provide Employee with full compensation for his past services rendered to the
Company.

The Company acknowledges that the Employee has performed administrative and
corporate services, for and on behalf of the Company, in his role as chief
executive officer of the Company from November 2002 to June 13, 2003. These
services have included, corporate administration, securities filings and
communications for and on behalf of the Company. All of these past services have
resulted in an outstanding Company debt due Employee in the amount of
$93,625.00. Pursuant to our discussions, Employee has agreed to accept 280,000
restricted shares of the Company's common shares (the "Shares") 1n full payment
of the Company's debt. In addition and as further consideration for Employee's
agreement to accept the Shares as payment, the Company shall utilize its best
efforts to register the Shares for sale to the public by including them in a
Form S-8 registration statement that the Company shall file with the Securities
and Exchange Commission under the Securities Act of 1933, as amended (the "1933
Act"). The Company shall issue the Shares in your individual name and identity
you as the selling shareholder in the registration statement. Upon the filing of
this Form S-8, we shall notify you of the date of its effectiveness and provide
you with the necessary copies of the prospectus to be used in any proposed sale
of the Shares.

Please indicate your agreement to the terms set forth in this correspondence by
signing your name where indicated below, returning a signed copy to me at your
convenience.

Very truly yours,

/s/ Peter F. Russo
-------------------------------
DELTA MUTUAL, INC.
Peter F. Russo, President

AGREED TO AND ACCEPTED BY:
Gary T. Robinson
By: /s/ Gary T. Robinson
    ---------------------------
        Gary T. Robinson

                                           Document is copied.<PAGE>

                                                                     EXHIBIT 4.2

                              PHARMION CORPORATION

                AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT

                                NOVEMBER 30, 2001

<PAGE>

                              PHARMION CORPORATION

                AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT

         This Amended and Restated Investors' Rights Agreement (the "Agreement")
is made as of the 30th day of November, 2001, by and among Pharmion Corporation,
a Delaware corporation (the "Company"), the investors listed on Exhibit A
hereto, each of which is herein referred to as a "Series A Investor," the
investors listed on Exhibit B hereto, each of which is herein referred to as a
"Series B Investor" (each such Series A Investor and Series B Investor further
being referred to as an "Investor"), who become parties to this Agreement by
executing and delivering a Financing Signature Page (as defined in the Purchase
Agreement referred to below), and Patrick Mahaffy and Judith Hemberger, each of
whom is herein referred to as a "Founder."

                                    RECITALS

         The Company, the Founders and the Series A Investors entered into an
Investors' Rights Agreement, dated January 5, 2000, in connection with the sale
of Series A-1 Preferred Stock and Series A-2 Preferred Stock of the Company
(collectively, the "Series A Preferred Stock") to the Series A Investors (the
"Original Agreement"). The Company and the Series B Investors have entered into
a Series B Preferred Stock Purchase Agreement (the "Purchase Agreement") of even
date herewith pursuant to which the Company desires to sell to the Series B
Investors, and the Series B Investors desire to purchase from the Company,
shares of the Company's Series B Preferred Stock (the "Series B Preferred Stock"
and, together with the Series A Preferred Stock, the "Preferred Stock"). A
condition to the Series B Investors' obligations under the Purchase Agreement is
that the Company, the Founders, the Series A Investors and the Series B
Investors enter into this Agreement in order to provide all of the Investors
with (i) certain rights to register shares of the Company's Common Stock
issuable upon conversion of the Series A Preferred Stock held by the Series A
Investors and conversion of the Series B Preferred Stock held by the Series B
Investors, (ii) certain rights to receive or inspect information pertaining to
the Company, and (iii) a right of first offer with respect to certain issuances
by the Company of its securities. The Company, the Series A Investors and the
Founders each desire to induce the Series B Investors to purchase shares of
Series B Preferred Stock pursuant to the Purchase Agreement by agreeing to amend
and restate the Original Agreement as set forth herein.

                                    AGREEMENT

         The parties hereby agree that the Original Agreement be amended and
restated in its entirety as follows:

         1.       REGISTRATION RIGHTS. The Company and the Investors covenant
and agree as follows:

                  1.1      DEFINITIONS. For purposes of this Section 1:

<PAGE>

                           (a)      The terms "register," "registered," and
"registration" refer to a registration effected by preparing and filing a
registration statement or similar document in compliance with the Securities Act
of 1933, as amended (the "Securities Act"), and the declaration or ordering of
effectiveness of such registration statement or document;

                           (b)      The term "Registrable Securities" means (i)
the shares of Common Stock issuable or issued upon conversion of the Series A
Preferred Stock and Series B Preferred Stock, including any shares of Common
Stock issuable or issued upon conversion of the Series B Preferred Stock
issuable or issued to Celgene Corporation (together with its permitted
successors and assigns, "Celgene") upon exercise of that certain Warrant to
purchase shares of Series B Preferred Stock, (ii) the shares of Common Stock
issued to the Founders (the "Founders' Stock"), provided, however, that for the
purposes of Section 1.2, 1.4 or 1.13 the Founders' Stock (other than any shares
of Common Stock issued upon conversion of their shares of Series A Preferred
Stock and Series B Preferred Stock held by them), shall not be deemed
Registrable Securities and the Founders shall not be deemed Holders, and (iii)
any other shares of Common Stock of the Company issued as (or issuable upon the
conversion or exercise of any warrant, right or other security which is issued
as) a dividend or other distribution with respect to, or in exchange for or in
replacement of, the shares listed in (i) and (ii); provided, however, that the
foregoing definition shall exclude in all cases any Registrable Securities sold
by a person in a transaction in which his or her rights under this Agreement are
not assigned. Notwithstanding the foregoing, Common Stock or other securities
shall only be treated as Registrable Securities if and so long as they have not
been (A) sold to or through a broker or dealer or underwriter in a public
distribution or a public securities transaction, or (B) sold in a transaction
exempt from the registration and prospectus delivery requirements of the
Securities Act under Section 4(1) thereof so that all transfer restrictions, and
restrictive legends with respect thereto, if any, are removed upon the
consummation of such sale;

                           (c)      The term "Series A Registrable Securities"
means Registrable Securities consisting of Common Stock issuable or issued upon
conversion of the Series A Preferred Stock, and the term "Series B Registrable
Securities" means Registrable Securities consisting of Common Stock issuable or
issued upon conversion of shares of Series B Preferred Stock;

                           (d)      The number of shares of "Registrable
Securities then outstanding" shall be determined by the number of shares of
Common Stock outstanding which are, and the number of shares of Common Stock
issuable pursuant to then exercisable or convertible securities which are,
Registrable Securities;

                           (e)      The term "Holder" means any person owning or
having the right to acquire Registrable Securities or any assignee thereof in
accordance with Section 1.12 of this Agreement;

                           (f)      The term "Form S-3" means such form under
the Securities Act as in effect on the date hereof or any successor form under
the Securities Act that permits significant incorporation by reference of the
Company's subsequent public filings under the Securities Exchange Act of 1934;

                                      -2-

<PAGE>

                           (g)      The term "SEC" means the Securities and
Exchange Commission; and

                           (h)      The term "Qualified IPO" means a firm
commitment underwritten public offering by the Company of shares of its Common
Stock pursuant to a registration statement under the Securities Act, the public
offering price of which is not less than $5.00 per share (appropriately adjusted
for any stock split, dividend, combination or other recapitalization) and which
results in aggregate cash proceeds to the Company of $20,000,000 (net of
underwriting discounts and commissions).

                  1.2      REQUEST FOR REGISTRATION.

                           (a)      If the Company shall receive at any time
after the earlier of (i) December 31, 2003 or (ii) six (6) months after the
effective date of the first registration statement for a public offering of
securities of the Company (other than a registration statement relating either
to the sale of securities to employees of the Company pursuant to a stock
option, stock purchase or similar plan or an SEC Rule 145 transaction), a
written request from the Holders of a majority of the Series A Registrable
Securities or 55% of the Series B Registrable Securities then outstanding that
the Company file a registration statement under the Securities Act covering the
registration of at least twenty-five percent (25%) of such series of Registrable
Securities then outstanding (or a lesser percent if the anticipated aggregate
offering price, net of underwriting discounts and commissions, would exceed
$10,000,000), then the Company shall, within ten (10) days of the receipt
thereof, give written notice of such request to all Holders and shall, subject
to the limitations of subsection 1.2(b), use its best commercial efforts to
effect as soon as practicable, and in any event within 60 days of the receipt of
such request, the registration under the Securities Act of all Registrable
Securities which the Holders request to be registered within twenty (20) days of
the mailing of such notice by the Company in accordance with Section 3.5.

                           (b)      If the Holders initiating the registration
request hereunder ("Initiating Holders") intend to distribute the Registrable
Securities covered by their request by means of an underwriting, they shall so
advise the Company as a part of their request made pursuant to this Section 1.2
and the Company shall include such information in the written notice referred to
in subsection 1.2(a). The underwriter will be selected by a majority in interest
of the Initiating Holders and shall be reasonably acceptable to the Company. In
such event, the right of any Holder to include his Registrable Securities in
such registration shall be conditioned upon such Holder's participation in such
underwriting and the inclusion of such Holder's Registrable Securities in the
underwriting (unless otherwise mutually agreed by a majority in interest of the
Initiating Holders and such Holder) to the extent provided herein. All Holders
proposing to distribute their securities through such underwriting shall
(together with the Company as provided in subsection 1.5(e)) enter into an
underwriting agreement in customary form with the underwriter or underwriters
selected for such underwriting. Notwithstanding any other provision of this
Section 1.2, if the underwriter advises the Initiating Holders in writing that
marketing factors require a limitation of the number of shares to be
underwritten, then the Initiating Holders shall so advise all Holders of
Registrable Securities which would otherwise be underwritten pursuant hereto,
and the number of shares of Registrable Securities that may be included in the
underwriting shall be allocated among all Holders thereof, including the
Initiating Holders, in proportion (as nearly as practicable) to the amount of
Registrable Securities of the Company

                                      -3-

<PAGE>

owned by each Holder; provided, however, that the number of shares of
Registrable Securities to be included in such underwriting shall not be reduced
unless all other securities are first entirely excluded from the underwriting.

                           (c)      Notwithstanding the foregoing, if the
Company shall furnish to Holders requesting a registration statement pursuant to
this Section 1.2, a certificate signed by the President of the Company stating
that in the good faith judgment of the Board of Directors of the Company, it
would be seriously detrimental to the Company and its stockholders for such
registration statement to be filed and it is therefore essential to defer the
filing of such registration statement, the Company shall have the right to defer
such filing for a period of not more than 120 days after receipt of the request
of the Initiating Holders; provided, however, that the Company may not utilize
this right more than once in any twelve-month period.

                           (d)      In addition, the Company shall not be
obligated to effect, or to take any action to effect, any registration pursuant
to this Section 1.2 with respect to either series of Registrable Securities:

                                    (i)      After the Company has effected two
(2) registrations pursuant to this Section 1.2 with respect to such series of
Registrable Securities and such registrations have been declared or ordered
effective;

                                    (ii)     During the period starting with the
date sixty (60) days prior to the Company's good faith estimate of the date of
filing of, and ending on a date one hundred eighty (180) days after the
effective date of, a registration subject to Section 1.3 hereof; provided that
the Company is actively employing in good faith all reasonable efforts to cause
such registration statement to become effective; or

                                    (iii)    If the Initiating Holders propose
to dispose of shares of Registrable Securities that may be immediately
registered on Form S-3 pursuant to a request made pursuant to Section 1.4 below.

                  1.3      COMPANY REGISTRATION. If (but without any obligation
to do so) the Company proposes to register (including for this purpose a
registration effected by the Company for stockholders other than the Holders)
any of its stock under the Securities Act in connection with the public offering
of such securities solely for cash (other than a registration relating solely to
the sale of securities to participants in a Company stock plan or a transaction
covered by Rule 145 under the Securities Act, a registration in which the only
stock being registered is Common Stock issuable upon conversion of debt
securities which are also being registered, the Company shall, at such time,
promptly give each Holder written notice of such registration. Upon the written
request of each Holder given within twenty (20) days after mailing of such
notice by the Company in accordance with Section 3.5, the Company shall, subject
to the provisions of Section 1.8, cause to be registered under the Securities
Act all of the Registrable Securities that each such Holder has requested to be
registered.

                  1.4      FORM S-3 REGISTRATION. In case the Company shall
receive from any Holder or Holders of the Registrable Securities then
outstanding a written request or requests that the Company effect a registration
on Form S-3 and any related qualification or compliance with

                                      -4-

<PAGE>

respect to all or a part of the Registrable Securities owned by such Holder or
Holders, the Company will:

                           (a)      promptly give written notice of the proposed
registration, and any related qualification or compliance, to all other Holders;
and

                           (b)      as soon as practicable, effect such
registration and all such qualifications and compliances as may be so requested
and as would permit or facilitate the sale and distribution of all or such
portion of such Holder's or Holders' Registrable Securities as are specified in
such request, together with all or such portion of the Registrable Securities of
any other Holder or Holders joining in such request as are specified in a
written request given within 15 days after receipt of such written notice from
the Company; provided, however, that the Company shall not be obligated to
effect any such registration, qualification or compliance, pursuant to this
Section 1.4: (i) if Form S-3 is not available for such offering by the Holders;
(ii) if the Holders, together with the holders of any other securities of the
Company entitled to inclusion in such registration, propose to sell Registrable
Securities and such other securities (if any) at an aggregate price to the
public (net of any underwriters' discounts or commissions) of less than
$1,000,000; (iii) if the Company shall furnish to the Holders a certificate
signed by the President of the Company stating that in the good faith judgment
of the Board of Directors of the Company, it would be seriously detrimental to
the Company and its stockholders for such Form S-3 Registration to be effected
at such time, in which event the Company shall have the right to defer the
filing of the Form S-3 registration statement for a period of not more than 120
days after receipt of the request of the Holder or Holders under this Section
1.4; provided, however, that the Company shall not utilize this right more than
once in any twelve month period; (iv) if the Company has, within the twelve (12)
month period preceding the date of such request, already effected two
registrations on Form S-3 for the Holders pursuant to this Section 1.4 and such
registrations have been declared or ordered effective; (v) in any particular
jurisdiction in which the Company would be required to qualify to do business or
to execute a general consent to service of process in effecting such
registration, qualification or compliance; or (vi) during the period ending one
hundred eighty (180) days after the effective date of a registration statement
subject to Section 1.3.

                           (c)      Subject to the foregoing, the Company shall
file a registration statement covering the Registrable Securities and other
securities so requested to be registered as soon as practicable after receipt of
the request or requests of the Holders. Registrations effected pursuant to this
Section 1.4 shall not be counted as demands for registration or registrations
effected pursuant to Sections 1.2 or 1.3, respectively.

                  1.5      OBLIGATIONS OF THE COMPANY. Whenever required under
this Section 1 to effect the registration of any Registrable Securities, the
Company shall, as expeditiously as reasonably possible:

                           (a)      Prepare and file with the SEC a registration
statement with respect to such Registrable Securities and use its best
commercial efforts to cause such registration statement to become effective as
soon as possible.

                                      -5-

<PAGE>

                           (b)      Prepare and file with the SEC any amendments
and supplements to the registration statement and the prospectus included in the
registration statement as may be necessary to comply with the provisions of the
Securities Act (including the anti-fraud provisions thereof) and to keep the
registration statement effective for twelve (12) months from the effective date
or such lesser period until all such Registrable Securities are sold.

                           (c)      Furnish to the Holders such numbers of
copies of a prospectus, including a preliminary prospectus, in conformity with
the requirements of the Securities Act, and such other documents as they may
reasonably request in order to facilitate the disposition of Registrable
Securities owned by them.

                           (d)      Use its best commercial efforts to register
and qualify the securities covered by such registration statement under such
other securities or Blue Sky laws of such jurisdictions as shall be reasonably
requested by the Holders, provided that the Company shall not be required in
connection therewith or as a condition thereto to qualify to do business or to
file a general consent to service of process in any such states or
jurisdictions.

                           (e)      In the event of any underwritten public
offering, enter into and perform its obligations under an underwriting
agreement, in usual and customary form, with the managing underwriter of such
offering. Each Holder participating in such underwriting shall also enter into
and perform its obligations under such an agreement.

                           (f)      Notify each Holder of Registrable Securities
covered by such registration statement at any time when a prospectus relating
thereto is required to be delivered under the Securities Act of the happening of
any event as a result of which the prospectus included in such registration
statement, as then in effect, includes an untrue statement of a material fact or
omits to state a material fact required to be stated therein or necessary to
make the statements therein not misleading in the light of the circumstances
then existing and all Holders of Registrable Securities covered by such
registration statement, upon receipt of such notice, shall immediately
discontinue any sales of Registrable Securities pursuant to such registration
statement until such Holder has received copies of a supplemented or amended
prospectus or until such Holder is advised in writing by the Company that the
then current prospectus may be used and has received copies of any additional or
supplemental filings that are incorporated or deemed incorporated by reference
in such prospectus.

                           (g)      Cause all such Registrable Securities
registered pursuant hereunder to be listed on each securities exchange on which
similar securities issued by the Company are then listed.

                           (h)      Provide a transfer agent and registrar for
all Registrable Securities registered pursuant hereunder and a CUSIP number for
all such Registrable Securities, in each case not later than the effective date
of such registration.

                           (i)      Use its best commercial efforts to furnish,
at the request of any Holder requesting registration of Registrable Securities
pursuant to this Section 1, on the date that such Registrable Securities are
delivered to the underwriters for sale in connection with a registration
pursuant to this Section 1, if such securities are being sold through
underwriters, or,

                                      -6-

<PAGE>

if such securities are not being sold through underwriters, on the date that the
registration statement with respect to such securities becomes effective, (i) an
opinion, dated such date, of the counsel representing the Company for the
purposes of such registration, in form and substance as is customarily given to
underwriters in an underwritten public offering, addressed to the underwriters,
if any, and to the Holders requesting registration of Registrable Securities and
(ii) a letter dated such date, from the independent certified public accountants
of the Company, in form and substance as is customarily given by independent
certified public accountants to underwriters in an underwritten public offering,
addressed to the underwriters, if any, and to the Holders requesting
registration of Registrable Securities.

                  1.6      FURNISH INFORMATION. It shall be a condition
precedent to the obligations of the Company to take any action pursuant to this
Section 1 with respect to the Registrable Securities of any selling Holder that
such Holder shall furnish to the Company such information regarding itself, the
Registrable Securities held by it, and the intended method of disposition of
such securities as shall be required to effect the registration of such Holder's
Registrable Securities. The Company shall have no obligation with respect to any
registration requested pursuant to Section 1.2 or Section 1.4 of this Agreement
if, as a result of the application of the preceding sentence, the number of
shares or the anticipated aggregate offering price of the Registrable Securities
to be included in the registration does not equal or exceed the number of shares
or the anticipated aggregate offering price required to originally trigger the
Company's obligation to initiate such registration as specified in subsection
1.2(a) or subsection 1.4(b), whichever is applicable.

                  1.7      EXPENSES OF REGISTRATION.

                           (a)      DEMAND REGISTRATION. All expenses other than
underwriting discounts and commissions incurred in connection with
registrations, filings or qualifications pursuant to Section 1.2 and 1.4,
including (without limitation) all registration, filing and qualification fees,
printers' and accounting fees, fees and disbursements of counsel for the
Company, and the reasonable fees and disbursements of one counsel for the
selling Holders selected by them with the approval of the Company, which
approval shall not be unreasonably withheld, shall be borne by the Company;
provided, however, that the Company shall not be required to pay for any
expenses of any registration proceeding begun pursuant to Section 1.2 or 1.4 if
the registration request is subsequently withdrawn at the request of the Holders
of a majority of the Registrable Securities to be registered other than as a
result of information concerning the business or financial condition of the
Company which is made known to such Holders after the date of the registration
request (in which case all participating Holders shall bear such expenses),
unless the Holders of a majority of the Registrable Securities agree to forfeit
their right to one demand registration pursuant to Section 1.2 or 1.4, as the
case may be.

                           (b)      COMPANY REGISTRATION. All expenses other
than underwriting discounts and commissions incurred in connection with
registrations, filings or qualifications of Registrable Securities pursuant to
Section 1.3 for each Holder (which right may be assigned as provided in Section
1.12), including (without limitation) all registration, filing, and
qualification fees, printers' and accounting fees, fees and disbursements of
counsel for the Company and the reasonable fees and disbursements of one counsel
for the selling Holder or Holders selected by

                                      -7-

<PAGE>

them with the approval of the Company, which approval shall not be unreasonably
withheld, shall be borne by the Company.

                  1.8      UNDERWRITING REQUIREMENTS. In connection with any
offering involving an underwriting of shares of the Company's capital stock, the
Company shall not be required under Section 1.3 to include any of the Holders'
securities in such underwriting unless they accept the terms of the underwriting
as agreed upon between the Company and the underwriters selected by it (or by
other persons entitled to select the underwriters), and then only in such
quantity as the underwriters determine in their sole discretion will not
jeopardize the success of the offering by the Company. If the total amount of
securities, including Registrable Securities, requested by stockholders to be
included in such offering exceeds the amount of securities sold other than by
the Company that the underwriters determine in their sole discretion is
compatible with the success of the offering, then the Company shall be required
to include in the offering only that number of such securities, including
Registrable Securities, which the underwriters determine in their sole
discretion will not jeopardize the success of the offering (the securities so
included to be apportioned pro rata among the selling stockholders according to
the total amount of securities entitled to be included therein owned by each
selling stockholder or in such other proportions as shall mutually be agreed to
by such selling stockholders) but in no event shall (i) the amount of securities
of the selling Holders included in the offering be reduced below thirty-five
percent (35%) of the total amount of securities included in such offering,
unless such offering is the initial public offering of the Company's securities,
in which case, the selling stockholders may be excluded if the underwriters make
the determination described above and no other stockholder's securities are
included or (ii) any securities held by the Founders be included if any
securities held by any other selling Holder are excluded. For purposes of the
preceding parenthetical concerning apportionment, for any selling stockholder
which is a holder of Registrable Securities and which is a partnership or
corporation, the partners, retired partners and stockholders of such holder, or
the estates and family members of any such partners and retired partners and any
trusts for the benefit of any of the foregoing persons shall be deemed to be a
single "selling stockholder," and any pro-rata reduction with respect to such
"selling stockholder" shall be based upon the aggregate amount of shares
carrying registration rights owned by all entities and individuals included in
such "selling stockholder," as defined in this sentence.

                  1.9      DELAY OF REGISTRATION. No Holder shall have any right
to obtain or seek an injunction restraining or otherwise delaying any such
registration as the result of any controversy that might arise with respect to
the interpretation or implementation of this Section 1.

                  1.10     INDEMNIFICATION. In the event any Registrable
Securities are included in a registration statement under this Section 1:

                           (a)      To the extent permitted by law, the Company
will indemnify and hold harmless each Holder, any underwriter (as defined in the
Securities Act) for such Holder and each person, if any, who controls such
Holder or underwriter within the meaning of the Securities Act or the Securities
Exchange Act of 1934, as amended (the "Exchange Act"), against any losses,
claims, damages, or liabilities (joint or several) to which they may become
subject under the Securities Act, the Exchange Act or other federal or state
law, insofar as such

                                      -8-

<PAGE>

losses, claims, damages, or liabilities (or actions in respect thereof) arise
out of or are based upon any of the following statements, omissions or
violations (collectively a "Violation"): (i) any untrue statement or alleged
untrue statement of a material fact contained in such registration statement,
including any preliminary prospectus or final prospectus contained therein or
any amendments or supplements thereto, (ii) the omission or alleged omission to
state therein a material fact required to be stated therein, or necessary to
make the statements therein not misleading, or (iii) any violation or alleged
violation by the Company of the Securities Act, the Exchange Act, any state
securities law or any rule or regulation promulgated under the Securities Act,
the Exchange Act or any state securities law; and the Company will pay to each
such Holder, underwriter or controlling person, as incurred, any legal or other
expenses reasonably incurred by them in connection with investigating or
defending any such loss, claim, damage, liability, or action; provided, however,
that the indemnity agreement contained in this subsection 1.10(a) shall not
apply to amounts paid in settlement of any such loss, claim, damage, liability,
or action if such settlement is effected without the consent of the Company
(which consent shall not be unreasonably withheld), nor shall the Company be
liable to any Holder, underwriter or controlling person for any such loss,
claim, damage, liability, or action to the extent that it arises out of or is
based upon a Violation which occurs in reliance upon and in conformity with
written information furnished expressly for use in connection with such
registration by any such Holder, underwriter or controlling person.

                           (b)      To the extent permitted by law, each selling
Holder, severally and not jointly, will indemnify and hold harmless the Company,
each of its directors, each of its officers who has signed the registration
statement, each person, if any, who controls the Company within the meaning of
the Securities Act, any underwriter, any other Holder selling securities in such
registration statement and any controlling person of any such underwriter or
other Holder, against any losses, claims, damages, or liabilities (joint or
several) to which any of the foregoing persons may become subject, under the
Securities Act, the Exchange Act or other federal or state law, insofar as such
losses, claims, damages, or liabilities (or actions in respect thereto) arise
out of or are based upon any Violation, in each case to the extent (and only to
the extent) that such Violation occurs in reliance upon and in conformity with
written information furnished by such Holder expressly for use in connection
with such registration; and each such Holder will pay, as incurred, any legal or
other expenses reasonably incurred by any person intended to be indemnified
pursuant to this subsection 1.10(b), in connection with investigating or
defending any such loss, claim, damage, liability, or action; provided, however,
that the indemnity agreement contained in this subsection 1.10(b) shall not
apply to amounts paid in settlement of any such loss, claim, damage, liability
or action if such settlement is effected without the consent of the Holder,
which consent shall not be unreasonably withheld; provided, that in no event
shall any indemnity under this subsection 1.10(b) exceed the net proceeds from
the offering received by such Holder, except in the case of willful fraud by
such Holder.

                           (c)      Promptly after receipt by an indemnified
party under this Section 1.10 of notice of the commencement of any action
(including any governmental action), such indemnified party will, if a claim in
respect thereof is to be made against any indemnifying party under this Section
1.10, deliver to the indemnifying party a written notice of the commencement
thereof and the indemnifying party shall have the right to participate in, and,
to the extent the indemnifying party so desires, jointly with any other
indemnifying party similarly noticed, to assume the defense thereof with counsel
mutually satisfactory to the parties;

                                      -9-

<PAGE>

provided, however, that an indemnified party (together with all other
indemnified parties which may be represented without conflict by one counsel)
shall have the right to retain one separate counsel, with the reasonable fees
and expenses to be paid by the indemnifying party, if representation of such
indemnified party by the counsel retained by the indemnifying party would be
inappropriate due to actual or potential differing interests between such
indemnified party and any other party represented by such counsel in such
proceeding. The failure to deliver written notice to the indemnifying party
within a reasonable time of the commencement of any such action, if materially
prejudicial to its ability to defend such action, shall relieve such
indemnifying party of any liability to the indemnified party under this Section
1.10, but the omission so to deliver written notice to the indemnifying party
will not relieve it of any liability that it may have to any indemnified party
otherwise than under this Section 1.10. No indemnifying party, in the defense of
any such claim or litigation shall, except with the consent of each indemnified
party, consent to entry of any judgment or enter into any settlement which does
not include as an unconditional term thereof the giving by the claimant or
plaintiff to such indemnified party of a release from all liability in respect
of such claim or litigation, and no indemnified party shall consent to entry of
any judgment or settle such claim or litigation without the prior written
consent of the indemnifying party, which consent shall not be unreasonably
withheld, conditioned or delayed.

                           (d)      If the indemnification provided for in this
Section 1.10 is held by a court of competent jurisdiction to be unavailable to
an indemnified party with respect to any loss, liability, claim, damage or
expense referred to therein, then the indemnifying party, in lieu of
indemnifying such indemnified party hereunder, shall contribute to the amount
paid or payable by such indemnified party as a result of such loss, liability,
claim, damage, or expense in such proportion as is appropriate to reflect the
relative fault of the indemnifying party on the one hand and of the indemnified
party on the other in connection with the statements or omissions that resulted
in such loss, liability, claim, damage or expense as well as any other relevant
equitable considerations; provided, that in no event shall any contribution by a
Holder under this Subsection 1.10(d) exceed the net proceeds from the offering
received by such Holder, except in the case of willful fraud by such Holder. The
relative fault of the indemnifying party and of the indemnified party shall be
determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission to state a material fact
relates to information supplied by the indemnifying party or by the indemnified
party and the parties' relative intent, knowledge, access to information, and
opportunity to correct or prevent such statement or omission.

                           (e)      Notwithstanding the foregoing, to the extent
that the provisions on indemnification and contribution contained in the
underwriting agreement entered into in connection with the underwritten public
offering are in conflict with the foregoing provisions, the provisions in the
underwriting agreement shall control.

                           (f)      The obligations of the Company and Holders
under this Section 1.10 shall survive the completion of any offering of
Registrable Securities in a registration statement under this Section 1, and
otherwise.

                  1.11     REPORTS UNDER SECURITIES EXCHANGE ACT OF 1934. With a
view to making available to the Holders the benefits of Rule 144 promulgated
under the Securities Act

                                      -10-

<PAGE>

and any other rule or regulation of the SEC that may at any time permit a Holder
to sell securities of the Company to the public without registration or pursuant
to a registration on Form S-3, the Company agrees to:

                           (a)      make and keep public information available,
as those terms are understood and defined in SEC Rule 144, at all times after
ninety (90) days after the effective date of the first registration statement
filed by the Company for the offering of its securities to the general public so
long as the Company remains subject to the periodic reporting requirements under
Sections 13 or 15(d) of the Exchange Act;

                           (b)      take such action, including the voluntary
registration of its Common Stock under Section 12 of the Exchange Act, as is
necessary to enable the Holders to utilize Form S-3 for the sale of their
Registrable Securities, such action to be taken as soon as practicable after the
end of the fiscal year in which the first registration statement filed by the
Company for the offering of its securities to the general public is declared
effective;

                           (c)      file with the SEC in a timely manner all
reports and other documents required of the Company under the Securities Act and
the Exchange Act; and

                           (d)      furnish to any Holder, so long as the Holder
owns any Registrable Securities, forthwith upon request (i) a written statement
by the Company that it has complied with the reporting requirements of SEC Rule
144 (at any time after ninety (90) days after the effective date of the first
registration statement filed by the Company), the Securities Act and the
Exchange Act (at any time after it has become subject to such reporting
requirements), or that it qualifies as a registrant whose securities may be
resold pursuant to Form S-3 (at any time after it so qualifies), (ii) a copy of
the most recent annual or quarterly report of the Company and such other reports
and documents so filed by the Company, and (iii) such other information as may
be reasonably requested in availing any Holder of any rule or regulation of the
SEC which permits the selling of any such securities without registration or
pursuant to such form.

                  1.12     ASSIGNMENT OF REGISTRATION RIGHTS. The rights to
cause the Company to register Registrable Securities pursuant to this Section 1
may be assigned (but only with all related obligations) by a Holder to a
transferee or assignee of at least 100,000 shares (subject to appropriate
adjustment for stock splits, stock dividends, recapitalizations and similar
events occurring after the date of this Agreement) of such securities, provided
the Company is, within a reasonable time after such transfer, furnished with
written notice of the name and address of such transferee or assignee and the
securities with respect to which such registration rights are being assigned;
and provided, further, that such assignment shall be effective only if
immediately following such transfer the further disposition of such securities
by the transferee or assignee is restricted under the Securities Act. For the
purposes of determining the number of shares of Registrable Securities held by a
transferee or assignee, the holdings of transferees and assignees of a
partnership who are partners or retired partners of such partnership and of a
corporation who are shareholders of such corporation (including spouses and
ancestors, lineal descendants and siblings of such partners or spouses who
acquire Registrable Securities by gift, will or intestate succession) shall be
aggregated together and with the partnership; provided that all assignees and
transferees who would not qualify individually for assignment of registration
rights shall have a

                                      -11-

<PAGE>

single attorney-in-fact for the purpose of exercising any rights, receiving
notices or taking any action under Section 1.

                  1.13     LIMITATIONS ON SUBSEQUENT REGISTRATION RIGHTS. From
and after the date of this Agreement, the Company shall not, without the prior
written consent of the Holders of a majority of the outstanding Registrable
Securities, enter into any agreement with any holder or prospective holder of
any securities of the Company (other than any purchaser of Series B Preferred
Stock issued pursuant to the Purchase Agreement) which would allow such holder
or prospective holder (a) to include such securities in any registration filed
under Section 1.2 hereof, unless under the terms of such agreement, such holder
or prospective holder may include such securities in any such registration only
to the extent that the inclusion of his securities will not reduce the amount of
the Registrable Securities of the Holders which is included or (b) to make a
demand registration which could result in such registration statement being
declared effective prior to the earlier of either of the dates set forth in
subsection 1.2(a) or within one hundred twenty (120) days of the effective date
of any registration effected pursuant to Section 1.2.

                  1.14     "MARKET STAND-OFF" AGREEMENT.

                           (a)      MARKET-STANDOFF PERIOD; AGREEMENT. In
connection with the initial public offering of the Company's securities and upon
request of the Company or the underwriters managing such offering of the
Company's securities, each Holder agrees not to sell, make any short sale of,
loan, grant any option for the purchase of, or otherwise dispose of any
securities of the Company (other than those included in the registration)
without the prior written consent of the Company or such underwriters, as the
case may be, for such period of time (not to exceed 180 days) from the effective
date of such registration as may be requested by the Company or such managing
underwriters and to execute an agreement reflecting the foregoing as may be
requested by the underwriters at the time of the Company's initial public
offering.

                           In connection with the first subsequent public
offering of the Company's securities and upon request of the Company or the
underwriters managing such offering of the Company's securities, each Holder
agrees not to sell, make any short sale of, loan, grant any option for the
purchase of, or otherwise dispose of any securities of the Company (other than
those included in the registration) without the prior written consent of the
Company or such underwriters, as the case may be, for such period of time (not
to exceed 90 days) from the effective date of such registration as may be
requested by the Company or such managing underwriters and to execute an
agreement reflecting the foregoing as may be requested by the underwriters at
the time of the Company's subsequent public offering.

                           (b)      LIMITATIONS. The obligations described in
Section 1.14(a) shall apply only if all officers and directors of the Company
enter into similar agreements, and shall not apply to a registration relating
solely to employee benefit plans, or to a registration relating solely to a
transaction pursuant to Rule 145 under the Securities Act.

                           (c)      RELEASE FROM RESTRICTIONS. As a condition to
the obligation of the Holders under this Section 1.14, the Company agrees to use
its commercially reasonable efforts to ensure that the "market stand off"
obligation of the Holders under this Section 1.14, and any

                                      -12-

<PAGE>

agreement entered into by the Holders as a result of their obligations under
this Section 1.14, shall (i) allow for periodic early releases of portions of
the securities subject to such "market stand off" obligations, which may be
conditioned upon the trading price of the Company's Common Stock and (ii)
provide that all persons subject to such "market stand off" obligations will
participate on a pro-rata basis in any such early release.

                           (d)      STOP-TRANSFER INSTRUCTIONS. In order to
enforce the foregoing covenants, the Company may impose stop-transfer
instructions with respect to the securities of each Holder (and the securities
of every other person subject to the restrictions in Section 1.14(a)).

                           (e)      TRANSFEREES BOUND. Each Holder agrees that
it will not transfer securities of the Company unless each transferee agrees in
writing to be bound by all of the provisions of this Section 1.14.

                  1.15     TERMINATION OF REGISTRATION RIGHTS. No Holder shall
be entitled to exercise any right provided for in this Section 1 after the
earlier of (i) seven (7) years following the consummation of a Qualified IPO,
(ii) such time as Rule 144 or another similar exemption under the Securities Act
is available for the sale of all of such Holder's shares during a three
(3)-month period without registration, or (iii) upon termination of the entire
Agreement upon a change in control of the Company, as provided in Section 3.1.

         2.       COVENANTS OF THE COMPANY.

                  2.1      DELIVERY OF FINANCIAL STATEMENTS. Until completion of
a Qualified IPO, the Company shall deliver to each Holder of at least 100,000
shares of Registrable Securities:

                           (a)      as soon as practicable, but in any event
within ninety (90) days after the end of each fiscal year of the Company, an
income statement for such fiscal year, a balance sheet of the Company and
statement of stockholder's equity as of the end of such year, and a statement of
cash flows for such year, such year-end financial reports to be in reasonable
detail, prepared in accordance with generally accepted accounting principles
("GAAP"), and audited and certified by an independent public accounting firm of
nationally recognized standing selected by the Company;

                           (b)      within forty-five (45) days of the end of
the quarter, an unaudited income statement and a statement of cash flows and
balance sheet for and as of the end of such quarter, in reasonable detail;

                           (c)      as soon as practicable, but in any event
thirty (30) days prior to the end of each fiscal year, a budget and business
plan for the next fiscal year, prepared on a monthly basis, and, as soon as
prepared, any other budgets or revised budgets prepared by the Company; and

                           (d)      subject to the proviso contained in Section
2.2, other information reasonably requested by such Holder;

                                      -13-

<PAGE>

                           (e)      with respect to the financial statements
called for in subsection (b) of this Section 2.1, an instrument executed by the
Chief Financial Officer or President of the Company and certifying that such
financials were prepared in accordance with GAAP consistently applied with prior
practice for earlier periods (with the exception of footnotes that may be
required by GAAP) and fairly present the financial condition of the Company and
its results of operation for the period specified, subject to year-end audit
adjustment, together with an executive summary covering all significant business
issues, provided that the foregoing shall not restrict the right of the Company
to change its accounting principles consistent with GAAP, if the Board of
Directors determines that it is in the best interest of the Company to do so.

                  2.2      INSPECTION. The Company shall permit each Holder of
at least 100,000 shares of Registrable Securities, at such Holder's expense, to
visit and inspect the Company's properties, to examine its books of account and
records and to discuss the Company's affairs, finances and accounts with its
officers, all at such reasonable times as may be requested by the Investor;
provided, however, that the Company shall not be obligated pursuant to this
Section 2.2 to provide access to any information to a Holder employed by a
competitor of the Company.

                  2.3      RIGHT OF FIRST OFFER. Subject to the terms and
conditions specified in this Section 2.3, the Company hereby grants to each
Investor a right of first offer with respect to future sales by the Company of
its Shares (as defined below). An Investor who chooses to exercise the right of
first offer may designate as purchasers under such right itself or its partners
or affiliates in such proportions as it deems appropriate.

                  Each time the Company proposes to offer any shares of, or
securities convertible into or exercisable for any shares of, any class of its
capital stock ("Shares"), the Company shall first make an offering of such
Shares to each Investor in accordance with the following provisions:

                           (a)      The Company shall deliver a notice by
certified mail ("Notice") to the Investors stating (i) its bona fide intention
to offer such Shares, (ii) the number of such Shares to be offered, and (iii)
the price and terms, if any, upon which it proposes to offer such Shares.

                           (b)      Within 15 calendar days after delivery of
the Notice, the Investor may elect to purchase or obtain, at the price and on
the terms specified in the Notice, up to that portion of such Shares which
equals the proportion that the number of shares of Common Stock issued and held,
or issuable upon conversion and exercise of all convertible or exercisable
securities then held, by such Investor bears to the total number of shares of
Common Stock then outstanding held by the Investors (assuming full conversion
and exercise of all convertible or exercisable securities). The Company shall
promptly, in writing, inform each Investor that purchases all the shares
available to it (each, a "Fully-Exercising Investor") of any other Investor's
failure to do likewise. During the ten (10)-day period commencing after receipt
of such information, each Fully-Exercising Investor shall be entitled to obtain
that portion of the Shares for which Investors were entitled to subscribe but
which were not subscribed for by the Investors that is equal to the proportion
that the number of shares of Common Stock issued and held, or issuable upon
conversion and exercise of all convertible or exercisable securities then held,
by such Fully-Exercising Investor bears to the total number of shares of Common
Stock

                                      -14-

<PAGE>

then held by the Fully-Exercising Investors (assuming full conversion and
exercise of all convertible or exercisable securities). The sale of Shares shall
take place at such time agreed to by the Investors subscribing for a majority of
the Shares to be sold hereunder or, if applicable, at the same closing as that
of any third party purchasers.

                           (c)      The Company may, during the 45-day period
following the expiration of the period provided in subsection 2.3(b) hereof,
offer the remaining unsubscribed portion of the Shares to any person or persons
at a price not less than, and upon terms no more favorable to the offeree than,
those specified in the Notice. If the Company does not enter into an agreement
for the sale of the Shares within such period, or if such agreement is not
consummated within 60 days of the execution thereof, the right provided
hereunder shall be deemed to be revived and such Shares shall not be offered
unless first reoffered to the Investors in accordance herewith.

                           (d)      The right of first offer in this paragraph
2.3 shall not be applicable (i) to the issuance or sale of Common Stock (or
options therefor) to employees, consultants and directors, pursuant to plans or
agreements approved by the Board of Directors for the primary purpose of
soliciting or retaining their services, (ii) to or after consummation of a
Qualified IPO, (iii) to the issuance of securities pursuant to the conversion or
exercise of convertible or exercisable securities, (iv) to the issuance of
securities in connection with the acquisition of all or substantially all of the
properties, assets or stock of another entity (including acquisitions by way of
merger or consolidation), the terms of which are approved by the Board of
Directors of the Company, (v) to the issuance of securities to financial
institutions or lessors in connection with commercial credit arrangements,
equipment financings, or similar transactions approved by the Board of Directors
of the Company, (vi) to the issuance or sale of the Series B Preferred Stock
pursuant to the Purchase Agreement, or (vii) to the issuance of securities that,
with unanimous approval of the Board of Directors of the Company, are not
offered to any existing stockholder of the Company.

                  2.4      TERMINATION OF COVENANTS.

                           (a)      The covenants set forth in Sections 2.1
through Section 2.3 shall terminate as to each Holder and be of no further force
or effect (i) immediately prior to the consummation of a Qualified IPO, or (ii)
upon termination of the entire Agreement upon a change in control of the
Company, as provided in Section 3.1.

                           (b)      The covenants set forth in Sections 2.1 and
2.2 shall terminate as to each Holder and be of no further force or effect when
the Company first becomes subject to the periodic reporting requirements of
Sections 13 or 15(d) of the Exchange Act, if this occurs earlier than the events
described in Section 2.4(a) above.

         3.       MISCELLANEOUS.

                  3.1      TERMINATION OF ENTIRE AGREEMENT UPON CHANGE OF
CONTROL. This Agreement shall terminate, and have no further force and effect,
when the Company shall sell, convey (including by way of license), or otherwise
dispose of all or substantially all of its property or business or a significant
portion of its intellectual property, or merge into or

                                      -15-

<PAGE>

consolidate with any other corporation, except any such merger or consolidation
involving the Company or a subsidiary in which the holders of capital stock of
the Company immediately prior to such merger or consolidation continue to hold
immediately following such merger or consolidation at least 50% by voting power
of the capital stock of (1) the surviving or resulting corporation or (2) if the
surviving or resulting corporation is a wholly owned subsidiary of another
corporation immediately following such merger or consolidation, the parent
corporation of such surviving or resulting corporation.

                  3.2      SUBORDINATION OF CLAIMS. The Series A Investors
hereby agree that to the extent they may have any claim against the Company for
breach of a representation or warranty in connection with the purchase by them
of the shares of Series A Preferred Stock from the Company which is based on
facts similar to facts underlying a claim that the Series B Investors may have
against the Company for breach of a representation or warranty by the Company in
connection with the purchase by the Series B Investors of the shares of Series B
Preferred Stock from the Company, all such rights they may have with respect to
any such claim shall be subordinated to the rights of the Series B Investors.

                  3.3      SUCCESSORS AND ASSIGNS. Except as otherwise provided
in this Agreement, the terms and conditions of this Agreement shall inure to the
benefit of and be binding upon the respective permitted successors and assigns
of the parties (including transferees of any of the Series A Preferred Stock,
Series B Preferred Stock or any Common Stock issued upon conversion thereof).
Nothing in this Agreement, express or implied, is intended to confer upon any
party other than the parties hereto or their respective successors and assigns
any rights, remedies, obligations, or liabilities under or by reason of this
Agreement, except as expressly provided in this Agreement.

                  3.4      AMENDMENTS AND WAIVERS. Any term of this Agreement
may be amended or waived only with the written consent of the Company and the
holders of a majority of the Series A Registrable Securities and 55% of the
Series B Registrable Securities then outstanding, not including the Founders'
Stock; provided that if such amendment has the effect of affecting the Founders'
Stock (i) in a manner different than securities issued to the Investors and (ii)
in a manner adverse to the interests of the holders of the Founders' Stock, then
such amendment shall require the consent of the holder or holders of a majority
of the Founders' Stock. Any amendment or waiver effected in accordance with this
paragraph shall be binding upon each party to the Agreement, whether or not such
party has signed such amendment or waiver, each future holder of all such
Registrable Securities, and the Company. Notwithstanding the foregoing, this
Agreement may be further amended for Celgene to join in, and be bound by, this
Agreement as a holder of Series B Registrable Securities hereunder, whereupon
the Company shall amend Exhibit B to include Celgene and deliver the amended
Exhibit B to each Investor no later than ten (10) days after Celgene becomes a
party.

                  3.5      NOTICES. All notices, requests, consents, and other
communications under this Agreement shall be in writing and shall be deemed
delivered (i) five business days after being sent by registered or certified
mail, return receipt requested, postage prepaid or if sent overseas, on the
tenth business day, (ii) one business day after being sent via a reputable
overnight courier service guaranteeing next business day delivery, or if sent
overseas on the second business day after being sent, (iii) at the time of
delivery thereof to the receiving party if

                                      -16-

<PAGE>

delivered by hand and (iv) at the time that receipt thereof has been
acknowledged by electronic confirmation or otherwise, if sent by telecopier, in
each case to the intended recipient as set forth below:

                  If to the Company, at Pharmion Corporation, 4865 Riverbend
Road, Boulder, CO 80301, Attention: Chief Executive Officer, or at such other
address or addresses as may have been furnished in writing by the Company to the
other parties hereto, with a copy to Willkie Farr & Gallagher, 787 Seventh
Avenue, New York, NY 10019-6099, Attention: Peter H. Jakes, Esq.;

                  If to a Founder or Investor, to the attention of the signatory
hereof at the address set forth on the signature pages (including Financing
Signature Pages) attached hereto, or at such other address or addresses as may
have been furnished to the Company in writing by such person or entity.

                  Any party may give any notice, request, consent or other
communication under this Agreement using any other means (including, without
limitation, personal delivery, messenger service, telecopy, first class mail or
electronic mail), but no such notice, request, consent or other communication
shall be deemed to have been duly given unless and until it is actually received
by the party for whom it is intended. Any party may change the address to which
notices, requests, consents or other communications hereunder are to be
delivered by giving the other parties notice in the manner set forth in this
Section.

                  3.6      SEVERABILITY. If one or more provisions of this
Agreement are held to be unenforceable under applicable law, the parties agree
to renegotiate such provision in good faith. In the event that the parties
cannot reach a mutually agreeable and enforceable replacement for such
provision, then (a) such provision shall be excluded from this Agreement, (b)
the balance of the Agreement shall be interpreted as if such provision were so
excluded and (c) the balance of the Agreement shall be enforceable in accordance
with its terms.

                  3.7      GOVERNING LAW. This Agreement and all acts and
transactions pursuant hereto shall be governed, construed and interpreted in
accordance with the laws of the State of Delaware, without giving effect to
principles of conflicts of laws.

                  3.8      COUNTERPARTS. This Agreement may be executed in any
number of counterparts (including, in the case of an Investor, a Financing
Signature Page) each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

                  3.9      TITLES AND SUBTITLES. The titles and subtitles used
in this Agreement are used for convenience only and are not to be considered in
construing or interpreting this Agreement.

                  3.10     AGGREGATION OF STOCK. All shares of the applicable
series of Preferred Stock held or acquired by affiliated entities or persons
shall be aggregated together for the purpose of determining the availability of
any rights under this Agreement.

                  3.11     WAIVER OF RIGHT OF FIRST OFFER UNDER THE ORIGINAL
AGREEMENT. Pursuant to the amendment and waiver provisions of the Original
Agreement, the Company and

                                      -17-

<PAGE>

a majority of the holders of the Registrable Securities (as defined in the
Original Agreement) outstanding hereby waive, in its entirety, Section 2.3 of
the Original Agreement as to the right of first offer with respect to the sale
of the shares of the Series B Preferred Stock, such waiver to be effective as of
the date hereof.

                  3.12     EFFECTIVENESS OF AGREEMENT. This Agreement shall
become effective when signed by the Company, the holders of a majority of the
Series A Registrable Securities and the holders of the Series B Registrable
Securities.

                            [Signature Pages Follow]

                                      -18-

<PAGE>

         The parties have executed this Amended and Restated Investors' Rights
Agreement as of the date first above written.

                          COMPANY:

                          PHARMION CORPORATION

                          By:  /s/ Patrick J. Mahaffy
                              -------------------------
                          Name:  Patrick J. Mahaffy
                          Title: President

                          Address: 4865 Riverbend Road
                                   Boulder, Colorado 80301

                          Fax: (303) 449-0569

                          FOUNDERS:

                          /s/ Patrick J. Mahaffy
                          ----------------------
                          Patrick J. Mahaffy

                          Address: 4865 Riverbend Road
                                   Boulder, Colorado 80301

                          Fax: (303) 449-0569

                          /s/ Judith A. Hemberger
                          -----------------------
                          Judith A. Hemberger

                          Address: 4865 Riverbend Road
                                   Boulder Colorado 80301

                          Fax: (303) 449-0569

<PAGE>

                          SERIES A INVESTORS:

                          VERSANT VENTURE CAPITAL I, L.P.

                          By: Versant Ventures I, LLC
                              Its General Partner

                          By: /s/ Brian Atwood
                              ----------------

                          Name: Brian Atwood
                                  (print)

                          Title: Managing Director

                          Address: 3000 Sand Hill Road
                                   BLDG. 1 - Suite 260
                                   Menlo Park, CA 94025

                          VERSANT SIDE FUND I, L.P.

                          By: Versant Ventures I, LLC
                              Its General Partner

                          By: /s/ Brian Atwood
                              ----------------

                          Name: Brian Atwood
                                  (print)

                          Title:  Managing Director

                          Address: 3000 Sand Hill Road
                                   BLDG. 1 - Suite 260
                                   Menlo Park, CA 94025

<PAGE>

                          DOMAIN PARTNERS IV, L.P.

                          By: One Palmer Square Associates IV,
                              L.L.C., its General Partner

                          By: /s/ Kathleen K. Schoemaker
                              --------------------------
                              Kathleen K. Schoemaker

                          Title: Managing Partner

                          Address: One Palmer Square
                                   Princeton, NJ 08542

                          DP IV ASSOCIATES, L.P.

                          By: One Palmer Square Associates IV,
                              L.L.C., its General Partner

                          By: /s/ Kathleen K. Schoemaker
                              ---------------------------
                                  Kathleen K. Schoemaker

                          Title: Managing Partner

                          Address: One Palmer Square
                                   Princeton, NJ 08542

                          ABERDARE VENTURES, L.P.

                          /s/ Paul H. Klingenstein
                          ------------------------
                          By:  Aberdare GP
                          L.L.C., its General Partner

                          By: /s/ Paul H. Klingenstein
                              ------------------------
                              Paul H. Klingenstein
                              Managing Partner

                          Address: One Embarcadero Ctr, #4000
                                   San Francisco, CA 94111

<PAGE>

                          ABINGWORTH BIOVENTURES II SICAV

                          By:  /s/ Jessica H. Collins
                               ----------------------
                          Name:  Jessica H. Collins
                          Title: Attorney-in-Fact

                          Address:  c/o Abingworth Management, Inc.
                                        2465 E. Bayshore Road, Suite 348
                                        Palo Alto, CA 94303

                          PATRICK J. MAHAFFY

                          /s/ Patrick J. Mahaffy
                          ----------------------------

                          Address:  4865 Riverbend Road
                                    Boulder, Colorado 80301

                          JUDITH A. HEMBERGER

                          /s/ Judith A. Hemberger
                          ----------------------------

                          Address:  4865 Riverbend Road
                                    Boulder, Colorado 80301

                          ROGER G. KENNEDY

                          /s/ Roger G. Kennedy
                          ----------------------------

                          Address:  855 El Caminito
                                    Santa Fe, New Mexico 87501

<PAGE>

                          TECHNOGEN ENTERPRISES LLC

                          By: /s/ Isaac Stein
                              ------------------------
                          Name:  Isaac Stein
                          Title: Member

                          Address:  P.O. Box 2088
                                    Menlo Park, CA 94026

                          JAMES C. YOUNG

                          /s/ James C. Young
                          ----------------------------

                          Address:  118 East Platte Avenue
                                    Colorado Springs, CO 80903

                          ANN YOUNG

                          /s/ Ann H. Young
                          ----------------------------

                          Address:  118 East Platte Avenue
                                    Colorado Springs, CO 80903

                          CAM GARNER

                          /s/ Cam Garner
                          ----------------------------

                          Address: 6363 Greenwich Dr.
                                   San Diego, CA 92122

<PAGE>

                          PETER H. JAKES and KAREN S. JAKES

                           /s/ Peter H. Jakes      /s/ Karen S. Jakes
                          -----------------------------------------------------

                          Address:  520 East 86th Street, Apt 13-C
                                    New York, New York 10028

                          ORRICK, HERRINGTON & SUTCLIFFE LLP

                          By: /s/ Peter Cohn
                             --------------------------------------------------
                          Name:  Peter Cohn
                          Title: _______________________________________________

                          Address:  1020 Marsh Road
                                     Menlo Park, CA 94025

                          PETER COHN, AS TRUSTEE, OR THE SUCCESSOR TRUSTEE OR
                          TRUSTEES, U/A/D, DATED JUNE 29, 1995, AS AMENDED,
                          CREATING THE PETER COHN REVOCABLE TRUST.

                          /s/ Peter Cohn
                          -----------------------------------------------------
                          Peter Cohn, Trustee

                          VERSANT AFFILIATES FUND 1-A, L.P.

                          By:  Versant Ventures I, LLC

                          By:  /s/ Brian Atwood
                               ----------------------------------------

                          Name:  Brian Atwood
                                   (print)

                          Title:  Managing Director

                          Address: 3000 Sand Hill Road
                                   BLDG. 1 - Suite 260
                                   Menlo Park, CA 94025

<PAGE>

                          VERSANT AFFILIATES FUND 1-B, L.P.

                          By:  Versant Ventures I, LLC

                          By:  /s/ Brian Atwood
                              -------------------------------------------------

                          Name:   Brian Atwood
                                    (print)

                          Title:  Managing Director

                          Address: 3000 Sand Hill Road
                                   BLDG. 1 - Suite 260
                                   Menlo Park, CA 94025

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