Document:

Exhibit
10.5

AMENDMENT
AND AFFIRMATION OF GUARANTY

This AMENDMENT AND  AFFIRMATION OF GUARANTY is made as of February 28, 2007, by and
among SAFEGUARD DELAWARE, INC. (“SDI”), SAFEGUARD SCIENTIFICS (DELAWARE), INC.
(“SSI”; collectively with SDI, “Guarantors”, each, a “Guarantor”) and COMERICA
BANK (“Bank”).

RECITALS

Bank and CLARIENT, INC.  (“Borrower”) are parties to that certain Loan
Agreement dated as of February 13, 2003, as amended, including without
limitation by that certain First Amendment to Loan Agreement dated as of
October 21, 2003, that certain Second Amendment to Loan Agreement dated as of
January 22, 2004, that certain Third Amendment to Loan Agreement dated as of
January 31, 2005, that certain Fourth Amendment to Loan Agreement dated as of
March 11, 2005, that certain Consent and Waiver dated as of July 13, 2005, that
certain letter agreement dated as of January 26, 2006, that certain Waiver and
Fifth Amendment to Loan Agreement dated as of August 1, 2006, that certain
Sixth Amendment to Loan Agreement dated as of February 28, 2006, and that
certain Seventh Amendment to Loan Agreement dated as of January 17, 2007
(collectively, the “Agreement”). 
Guarantors executed for the benefit of Bank a Third Amended and Restated
Unconditional Guaranty dated as of January 17, 2007 (the “Guaranty”),
guarantying amounts owing by Borrower to Bank.  
Borrower and Bank propose to enter into a Waiver and Eighth Amendment to
Loan Agreement of even date herewith (the “Amendment’), which amends the Loan
Agreement by, among other things, extending the maturity date.  Bank has agreed to enter into the Amendment
provided, among other things, that each Guarantor consents to the Amendment and
agrees that the Guaranty will remain effective.

AGREEMENT

NOW, THEREFORE, each  Guarantor agrees as follows:

1.             Each Guarantor
consents to the execution, delivery and performance by Borrower of the
Amendment and the documents and instruments executed in connection therewith.  The Guaranty is and shall remain in full
force and effect with respect to Borrower’s Obligations (as defined in the
Agreement) as modified by the Amendment and otherwise.  Each Guarantor confirms that, as of the date
hereof, such Guarantor has no defenses against its obligations under the
Guaranty.

2.             Notwithstanding
any other provisions of the Guaranty, following the occurrence and during the
continuation of any Event of Default under the Agreement, Bank may request
payment under the Guaranty without accelerating the Obligations under the
Agreement, demanding payment from Borrower, or otherwise exercising any
remedies under the Guaranty.

3.             The reference to “Twelve
Million Dollars ($12,000,000)” in Section 1 of the Guaranty is amended to read “Twelve
Million Three Hundred Thousand Dollars ($12,300,000)”.

4.             The Guaranty, as
amended, shall be and shall remain in full force and effect in accordance with
its terms and hereby is ratified and confirmed in all respects.  Except as expressly set forth herein, the
execution, delivery, and performance of this Affirmation shall not operate as a
waiver of, or as an amendment of, any right, power, or remedy of Bank under the
Guaranty, as in effect prior to the date hereof.  Each Guarantor ratifies and reaffirms the
continuing effectiveness of all instruments, documents and agreements entered
into in connection with the Guaranty.

5.             Each Guarantor
represents and warrants that the Representations and Warranties contained in
the Guaranty are true and correct as of the date of this Amendment and Affirmation
other than (i) to the extent such representations and warranties expressly
relate to an earlier date, which representations and warranties are true and
correct as of such date; and (ii) for those changes to the representations and
warranties resulting from events, occurrences or circumstances permitted under
the applicable Loan Documents, as amended. 
Unless otherwise defined, all capitalized terms in this Affirmation
shall be as defined in the Guaranty. 
This Affirmation may be signed in two or more counterparts, each of
which shall be deemed an original and all of which shall constitute one
instrument.

IN WITNESS WHEREOF, the
undersigned have executed this Amendment and Affirmation of Guaranty as of the
first date above written.

	
   

  	
  SAFEGUARD DELAWARE, INC.

  
	
   

  	
   

  
	
   

  	
  By: 

  	
  /s/ Steven J.
  Feder

  	
   

  
	
   

  	
   

  
	
   

  	
  Title: 

  	
  Vice President

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  SAFEGUARD
  SCIENTIFICS (DELAWARE), INC.

  
	
   

  	
   

  
	
   

  	
  By: 

  	
  /s/ Steven J.
  Feder

  	
   

  
	
   

  	
   

  
	
   

  	
  Title: 

  	
  Vice President

  	
   

  
	
   

  	
   

  
	
   

  	
  COMERICA BANK

  
	
   

  	
   

  
	
   

  	
  By: 

  	
  /s/ Beth Kinsey

  	
   

  
	
   

  	
   

  
	
   

  	
  Title: 

  	
  Senior Vice
  President

  	
   

  
											

 

 2Exhibit
10.6

CONSENT AND FIRST AMENDMENT TO LOAN AND SECURITY
AGREEMENT

THIS CONSENT AND FIRST AMENDMENT TO LOAN AND
SECURITY AGREEMENT (this “Agreement”)
is made effective as of January 17, 2007, by and among CLARIENT,
INC., a Delaware corporation (“Clarient”), CLRT ACQUISITION, LLC, a Delaware limited liability company
(“CLRT”) and CLARIENT
DIAGNOSTIC SERVICES, INC., a Delaware corporation (“CDS”; Clarient, CLRT and CDS, each a “Company”,
and collectively, the “Companies”),
and GENERAL ELECTRIC CAPITAL CORPORATION, a
Delaware corporation (the “Lender”), as
lender under the Loan Agreement described below.

W  I  T  N  E
S  S  E  T  H:

WHEREAS, Lender and
the Companies are parties to that certain Loan and Security Agreement, dated as
of September 29, 2006, by and among Clarient, CDS, CLRT, the other credit
parties signatory thereto from time to time, and Lender (as amended, restated,
supplemented, replaced, extended, renewed, rolled-over, refunded or otherwise
modified from time to time, the “Loan Agreement”);

WHEREAS, Comerica
Bank (“Comerica”) and Clarient are parties to
that certain Loan Agreement, dated as of February 13, 2003, by and between
Clarient and Comerica (as amended, restated, supplemented, replaced, extended,
renewed, rolled-over, refunded or otherwise modified from time to time, the “Subordinated  Loan Agreement”);

WHEREAS, Lender, Comerica and
the Companies are parties to that certain Subordination Agreement, dated as of
September 29, 2006 (as amended, modified or restated from time to time, the “Comerica  Subordination Agreement”);

WHEREAS, Lender, Safeguard
Scientifics, Inc., a Delaware corporation (“SSI”), Safeguard Scientifics
(Delaware), Inc., a Delaware corporation (“SSDI”), Safeguard Delaware,
Inc., a Delaware corporation (“SDI”), and the Companies are parties to
that certain Subordination Agreement, dated as of September 29, 2006 (as
amended, modified or restated from time to time, the “Safeguard
Subordination Agreement”);

WHEREAS, Clarient
has requested that Lender consent to the amendment of the Subordinated Loan
Agreement by Clarient and Comerica to increase the maximum principal amount of
the Subordinated Debt under the Subordinated Loan Agreement by $3,500,000 and
to certain related actions, in each case subject to the terms and conditions
hereof; and

WHEREAS, the parties hereto are
willing to make certain amendments to the Loan Agreement as more particularly
set forth herein, subject to the terms and conditions hereof.

NOW, THEREFORE, in consideration
of the premises, the covenants and agreements contained herein, and other good
and valuable consideration, the receipt and adequacy of which are hereby
acknowledged, the parties do hereby agree as follows:

1.             Definitions.  All capitalized terms used herein but not
otherwise defined herein shall have the meanings given such terms in the Loan
Agreement.

2.             Consent
and Limited Waiver.

(a)           Subject to the terms and conditions
hereof, Lender hereby consents that Clarient may (i) with Comerica amend the
Subordinated Loan Agreement to increase the maximum principal amount that may
be outstanding thereunder at any time by $3,500,000, to a maximum of
$12,000,000 (such $3,500,000 increase in the maximum principal amount, the “Additional
Subordinated Loan”), pursuant to that certain Seventh Amendment to Loan Agreement,
dated as of January 17, 2007, attached hereto as Exhibit A, and may
borrow up to the full amount of the Additional Subordinated Loan, (ii) enter
into an Amended and Restated Reimbursement and Indemnity Agreement (the “Amended
Safeguard Reimbursement Agreement”) with SSDI and SDI, in substantially the
form attached hereto as Exhibit B, (iii) issue to SDI warrants to
purchase up to 350,000 shares of the capital stock of Clarient, in each case in
substantially the form attached hereto as Exhibit C, and (iv) use up to
$1,000,000 of borrowings under the initial advance of the Additional
Subordinated Loan to repay to SDI an aggregate of $1,000,000 in respect of that
certain $1,000,000 advance made by SDI to Clarient on January 11, 2007 (the “Safeguard
Advance”); provided, however, that (i) neither Clarient nor any
other Company may pay to SSI, SSDI or SDI or any of their Affiliates any
amounts owing by Clarient under the Amended Safeguard Reimbursement Agreement
except to the extent that any such payments are expressly permitted under the
terms and conditions of the Safeguard Subordination Agreement, as the same has
been amended pursuant to that certain First Amendment to Subordination
Agreement, dated as of the date hereof (and as the same may hereafter be further
amended with Lender’s consent), by and among the Companies, Lender, SSI, SSDI
and SDI, and (ii) any amounts owing by Clarient to Comerica with respect to the
Additional Subordinated Loan may only be repaid in accordance with the terms
and conditions of the Comerica Subordination Agreement, as the same has been
amended pursuant to that certain First Amendment to Subordination Agreement,
dated as of the date hereof (and as the same may hereafter be further amended
with Lender’s consent), by and among the Companies, Lender and Comerica.  Except as expressly provided herein, the
execution and delivery of this Agreement does not and will not constitute a
consent to or a waiver of any noncompliance with the provisions of the Loan
Agreement.

(b)           Lender hereby waives any Default or
Event of Default that has occurred under Section 8.1 of the Loan
Agreement as a result of SDI making the Safeguard Advance to Clarient.  The waiver in this Section 2(b)
relates solely to the making of the Safeguard Advance to Clarient, and nothing
in this Section 2(b) is intended (or shall be construed) to constitute a
waiver by Lender of any other Default or Event of Default (including, without
limitation, any Subject Event of Default (as defined below in Section 4)).

3.             Amendment
to Loan Agreement.

The
parties hereby agree that Section 1.1 of the Loan Agreement is amended
by deleting the defined terms “Safeguard Reimbursement Agreement” and “Safeguard
Subordination Agreement” and by inserting, in lieu thereof, the following new
defined terms:

“Safeguard Reimbursement Agreement”
means that certain Amended and Restated Reimbursement and Indemnity Agreement,
dated as of January 17, 2007, by and between certain Affiliates of Safeguard
and Clarient, in respect of certain Indebtedness 

 2
 

owing
to such Affiliates of Safeguard by Clarient, as the same may be amended,
restated, supplemented or otherwise modified, provided that the
foregoing amendments, restatements, supplements or modifications are permitted
by the Safeguard Subordination Agreement or are otherwise consented to by
Lender in writing.

“Safeguard Subordination Agreement”
means that certain Subordination Agreement, dated as of September 29, 2006, by
and between the Borrowers, Safeguard and certain of its Affiliates and Lender,
in respect of Indebtedness owing to Safeguard or such Affiliates by Borrowers,
as amended by that certain First Amendment to Subordination Agreement, dated as
of January 17, 2007, and as further amended, restated, supplemented or
otherwise modified from time to time.

4.             Reservation
of Rights of Lender.

(a)           Certain
Events of Default have occurred under the Loan Agreement as a result of (1) the
failure of the Companies to maintain the minimum Net Worth (as such term is
defined in the Loan Agreement) as required pursuant to clause (c) of Annex X to
the Loan Agreement for the period from October 2006 until January 17, 2007 and
(2) the failure of the Companies to maintain minimum Operating Cash
Requirements coverage for the month ending October 31, 2006 as required pursuant
to clause (b) of Annex X to the Loan Agreement (such Events of Default, the “Subject Events of Default”).

(b)           Under
the terms of the Loan Agreement and the other Loan Documents (as such term is
defined in the Loan Agreement) as well as applicable law, the Lender has
certain rights and remedies with respect to the Subject Events of Default and
the Lender is presently evaluating all available courses of action relating to
the Subject Events of Default.  Accordingly,
without waiving any existing Defaults or Events of Default (including without
limitation, the Subject Events of Default), the Lender reserves all of its
rights and remedies under the Loan Agreement, the other Loan Documents and
applicable law, and the Lender’s voluntary forbearance, if any, from exercising
any of such rights or remedies, and the Lender’s entering into this Agreement,
is not intended (and should not be construed) as a waiver of the Subject Events
of Default or a waiver of its rights and remedies with respect to them, all of
which are reserved by the Lender.

5.              Reaffirmation of
Loan Agreement.

Except
for the consents and the amendments to the Loan Agreement expressly provided in
Sections 2 and 3 above, the Loan Agreement shall remain unchanged
and in full force and effect in accordance with its terms, and this Agreement
shall be limited precisely and expressly as drafted and shall not be construed
as a consent to the amendment, restatement, modification, supplementation or
waiver of any other terms or provisions of the Loan Agreement.  Without limiting the generality of the
foregoing, the Lender has not consented to any sale of any assets of Clarient
or issuance of equity securities or convertible notes by Clarient to the extent
that the same are not permitted under the Loan Agreement, and any such consent,
if given by Lender in its sole discretion, would be set forth in a separate
consent agreement expressly permitting such action.

 3
 

6.             Conditions
Precedent to Effectiveness of this Agreement.  The effectiveness of this Agreement is
subject to the satisfaction of each of the following conditions precedent:

a.               receipt by Lender of one or
more counterparts of this Agreement duly executed and delivered by the
Companies;

b.              receipt by Lender of one or
more counterparts of that certain First Amendment to Subordination Agreement,
dated as of the date hereof, duly executed and delivered by the Companies and
Comerica;

c.               receipt by Lender of one or
more counterparts of that certain First Amendment to Subordination Agreement,
dated as of the date hereof, duly executed and delivered by the Companies, SSI,
SSDI and SDI; and

d.              receipt by Lender of a
consent fee in the amount of $5,000.00, which fee shall be fully earned and
non-refundable upon payment.

7.             Provisions of
General Application.

(a)           Costs and Expenses.  Each Company absolutely and unconditionally
agrees to pay to Lender, on demand by Lender at any time and as often as the
occasion therefore may require, whether or not all or any of the transactions
contemplated by this Agreement are consummated: all reasonable fees and
disbursements of any counsel to Lender in connection with the preparation,
negotiation, execution, or delivery of this Agreement and expenses which shall
at any time be incurred or sustained by Lender or any of its directors,
officers, employees or agents as a consequence of or in any way in connection
with the preparation, negotiation, execution, or delivery of this Agreement and
any agreements prepared, negotiated, executed or delivered in connection with
the transactions contemplated hereby.

(b)           Further Assurances.  The parties hereto shall execute and deliver
such additional documents and take such additional action as may be necessary
or desirable to effectuate the provisions and purposes of this Agreement.

(c)           Binding Effect.  This
Agreement shall be binding upon and inure to the benefit of each of the parties
hereto and their respective successors and assigns.

(d)           Severability.  Any
provision of this Agreement held by a court of competent jurisdiction to be
invalid or unenforceable shall not impair or invalidate the remainder of this
Agreement.

(e)           Governing Law.  EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN ANY
OF THE LOAN DOCUMENTS, IN ALL RESPECTS, INCLUDING ALL MATTERS OF CONSTRUCTION,
VALIDITY AND PERFORMANCE, THIS AGREEMENT AND THE OTHER LOAN DOCUMENTS AND THE
OBLIGATIONS ARISING UNDER THE LOAN DOCUMENTS SHALL BE GOVERNED BY, AND
CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK
APPLICABLE TO CONTRACTS MADE AND PERFORMED 

 4
 

IN SUCH STATE, WITHOUT REGARD TO THE PRINCIPLES THEREOF REGARDING
CONFLICTS OF LAWS, AND ANY APPLICABLE LAWS OF THE UNITED STATES OF AMERICA.

[Signature Page to Follow]

 5

IN WITNESS WHEREOF, the parties
hereto have caused this Consent and First Amendment to Loan and Security
Agreement to be duly executed and delivered as of the day and year specified at
the beginning hereof.

	
   

  	
  COMPANIES:

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  CLARIENT, INC.

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  

  	
  By:

  	
  /s/ James V.
  Agnello

  	
   

  
	
   

  	
   

  	
  Name: 

  	
   

  	
  James V. Agnello

  	
   

  
	
   

  	
   

  	
  Title:

  	
    Senior Vice President and Chief
  Financial Officer

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  CLARIENT DIAGNOSTIC SERVICES, INC.

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ James V.
  Agnello

  	
   

  
	
   

  	
   

  	
  Name:

  	
   

  	
  James V. Agnello

  	
   

  
	
   

  	
   

  	
  Title:

  	
    Senior Vice President and Chief
  Financial Officer

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  CLRT ACQUISITION, LLC

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  Clarient, Inc., its sole member

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  /s/ James V.
  Agnello

  	
   

  
	
   

  	
   

  	
  Name: 

  	
   

  	
  James V. Agnello

  	
   

  
	
   

  	
   

  	
  Title: 

  	
    Senior Vice President and Chief
  Financial Officer

  	
   

  
											

 

 

	
  

  	
  LENDER:

  
	
   

  	
   

  	
   

  
	
   

  	
  GENERAL ELECTRIC CAPITAL CORPORATION

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  By:

  	
  Thomas A.
  Buckelew

  
	
   

  	
   

  	
  Name:

  	
  Thomas A.
  Buckelew

  
	
   

  	
   

  	
  Title:

  	
  Its Duly
  Authorized Signatory

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