Document:

Form of Warrant

 Exhibit 10.18 
 THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE, AND MAY BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED AND QUALIFIED
PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT
REQUIRED OR IF THE COMPANY OTHERWISE SATISFIES ITSELF THAT REGISTRATION IS NOT REQUIRED. 
 WARRANT TO PURCHASE SHARES OF COMMON STOCK

 OF 
 ALSIUS
CORPORATION, 
 a California corporation 
 Date of Grant: October 2, 2006 
 This certifies that for the purchase price paid, the undersigned holder of this Warrant (the “Original Holder”) and any person to whom the interest in this Warrant is lawfully transferred (the Original Holder hereof and such
transferees referred to hereinafter as the “Holder”), is entitled to purchase up to that number of shares of Common Stock, no par value (the “Common Stock”) of Alsius Corporation, a California corporation (the
“Company”) as determined pursuant to Section 1(b) hereof, pursuant to the terms of this Warrant. This Warrant is being issued in connection with a series of convertible promissory notes issued by the Company on the Date of Grant of
this Warrant (such notes, together with convertible notes issued by the Company in April 2006 and August 2006 and convertible notes issued by the Company having substantially the same terms that are later issued, the “Bridge Notes”). The
Bridge Notes are automatically convertible into Common Stock upon the closing of an underwritten public offering of the Company’s Common Stock (the “IPO”). 
 1. Exercise of Warrant. 
 (a) Exercise Price; Aggregate Exercise Price. The
price per share at which this Warrant may be exercised (the “Exercise Price”) will be equal to (i) in the case of an IPO, the public offering price per share of Common Stock in the IPO as stated on the front cover of the final IPO
prospectus (before deduction of any underwriting commissions, expenses or other amounts) or (ii) in the event that an IPO or sale of the Company has not occurred prior to the Maturity Date (as defined in the Bridge Notes) of the Bridge Notes,
as described below in this Section 1(a), the current $3.00 price per share of the Series F Preferred Stock (as adjusted for stock splits, consolidations, recapitalizations and the like that may occur after the date hereof). This Warrant will
automatically become a Warrant to purchase shares of Series F Preferred 

 
Stock if no IPO or sale of the Company causing conversion of the Bridge Notes occurs prior to the Maturity Date of the Bridge Notes (including any extension
thereof in accordance with the terms of the Bridge Notes) and all references to Common Stock in this Warrant shall become a reference to Series F Preferred Stock. In the event of a Sale Transaction (as defined in the Bridge Notes), this Warrant will
be automatically cancelled. The initial “Aggregate Exercise Price” will be the amount resulting from multiplying the Exercise Price times the total number of shares of the stock that may be purchased upon exercise hereof. 
 (b) Number of Shares. Subject to the exercisability restrictions set forth in Section 1(c) hereof, this Warrant will entitle
the Holder to purchase (i) in the event of an IPO, a number of shares of Common Stock equal to the quotient obtained by dividing twenty percent (20%) of the original principal amount of the Holder’s Bridge Note by the public offering
price per share of Common Stock in the IPO as stated on the front cover of the final IPO prospectus (before deduction of any underwriting commissions, expenses or other amounts), and (ii) in the event that an IPO or Sale Transaction has not
occurred prior to the Maturity Date of the Bridge Notes, the quotient obtained by dividing twenty percent (20%) of the original principal amount of the Holder’s Bridge Note by the $3.00 price per share of the Series F Preferred Stock (as
adjusted for stock splits, consolidations, recapitalizations and the like that may occur after the date hereof). 
 (c)
Exercise Period. This Warrant will become exercisable on the earlier of (i) closing of an IPO in which the Bridge Notes automatically convert into Common Stock and (ii) the maturity date of the Bridge Notes (including any extension
thereof in accordance with the terms of the Bridge Notes) (the “Exercise Date”). This Warrant will be exercisable for a period of three (3) years from the Exercise Date. 
 (d) Method of Exercise; Payment. The purchase right represented by this Warrant may be exercised by the Holder, in whole or in
part, for up to the total number of shares remaining available for exercise by the surrender of this Warrant (with the notice of exercise form attached hereto as Annex I duly executed) at the principal office of the Company and by payment to the
Company, by: (i) check made payable to the Company drawn on a United States bank and for United States funds, (ii) wire transfer of immediately available funds, (iii) delivery to the Company of evidence of cancellation of indebtedness
of the Company to such Holder, or (iv) any combination thereof, of an amount in each case equal to the then applicable Exercise Price per share multiplied by the number of shares of Common Stock then being purchased. Upon partial exercise, the
Company will promptly issue an amended warrant representing the remaining number of shares purchasable hereunder. All other terms and conditions of such amended warrant will be identical to those contained herein, including, but not limited to the
effective date hereof. 
 (e) Net Exercise. In the event that the Company’s Common Stock is then traded on a
national securities exchange or admitted to unlisted trading privileges on such an exchange, or is listed on the National Market (the “National Market”) of the National Association of Securities Dealers Automated Quotations System (the
“Nasdaq”) or other over-the-counter quotation system, this Warrant shall represent the right to purchase Common Stock and then the Holder may elect to receive, without the payment by the Holder of any additional consideration, shares equal
to the value of this Warrant, or any portion hereof, by the surrender 

  

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of this Warrant or such portion to the Company (with the notice of exercise form attached hereto as Annex I duly executed). Thereupon, the Company will issue
to the Holder such number of fully paid and nonassessable shares of Common Stock as is computed using the following formula: 
  

							
		  		  	Y (A - B)
				
		  	X =	  		  	A
				
	Where:	  	X =	  		  	The number of shares of Common Stock to be issued to the Holder pursuant to this net exercise;
				
		  	Y =	  		  	The number of shares of Common Stock in respect of which the net issue election is made;
				
		  	A =	  		  	The fair market value of one share of the Company’s Common Stock at the time the net issue election is made;
				
		  	B =	  		  	The Exercise Price in effect under this Warrant at the time the net issuance election is made pursuant to this Section 1(e).

 For purposes of this Section 1(e), the fair market value of one share of the Company’s
Common Stock as of a particular date will be determined as follows: (i) if traded on a securities exchange or through the Nasdaq National Market, the value will be deemed to be the average of the closing prices of the securities on such
exchange for the ten (10) trading days ending on the trading day prior to the net exercise election; and (ii) if traded over-the-counter, the value will be deemed to be the average of the closing bid or sale prices (whichever is
applicable) for the ten (10) trading days ending on the trading day prior to the net exercise. 
 (f) Issuance of New
Warrant. In the event of any exercise of the purchase right represented by this Warrant, certificates for the shares of Common Stock (or such other series of stock then issuable upon exercisable of this Warrant) so purchased will be delivered to
the Holder within fifteen (15) business days after receipt of such payment and, unless this Warrant has been fully exercised or has expired, a new warrant representing the portion of the shares of Common Stock (or such other series of stock
then issuable upon exercisable of this Warrant), if any, with respect to which this Warrant will not then have been exercised will also be issued to the Holder within a fifteen (15) business day period. 
 2. Adjustment of Number and Kind of Securities and Adjustment of Exercise Price. The number and kind of securities purchasable upon the exercise
of this Warrant, and the Exercise Price, will be subject to adjustment from time to time upon the occurrence of certain events, as follows: 
 (a) Reclassification, Reorganization, Consolidation or Merger. In case of any reclassification of the Common Stock of the Company, or any reorganization, consolidation or merger of the Company with or into
another corporation (other than a merger or reorganization with respect to which the Company is the continuing corporation and which does not result in any reclassification of the Common Stock), the Company, or such successor corporation, as the
case may be, will execute and deliver to the Holder a new warrant in substitution for this Warrant 

  

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which will provide that the Holder will have the right to exercise such new warrant and upon such exercise to receive, in lieu of each share of Common Stock
issuable upon exercise of this Warrant, the number and kind of securities, money and property receivable upon such reclassification, reorganization, consolidation or merger by a holder of shares of Common Stock of the Company for each share of
Common Stock. Such new warrant will provide for adjustments which will be as nearly equivalent as may be practicable to the adjustments provided for in this Section 2 including, without limitation, adjustments to the Exercise Price and to the
number of shares issuable upon exercise of this Warrant. The provisions of this Section 2(a) will similarly apply to successive reclassifications, reorganizations, consolidations or mergers. Notwithstanding the foregoing, pursuant to
Section 1(a) hereof, this Warrant shall automatically terminate upon a Sale Transaction. 
 (b) Split, Subdivision or
Combination of Shares. If the Company at any time while this Warrant remains outstanding and unexpired splits, subdivides or combines its Common Stock, the Exercise Price will be proportionately decreased in the case of a split or subdivision or
proportionately increased in the case of a combination. Any adjustment under this Section 2(b) will become effective when the split, subdivision or combination becomes effective. 
 (c) Stock Dividends. If the Company at any time while this Warrant remains outstanding and unexpired will pay a dividend with
respect to the Common Stock payable in shares of Common Stock, or securities convertible into or exchangeable for Common Stock (“Convertible Securities”), the Exercise Price will be adjusted, from and after the date of determination of the
shareholders entitled to receive such dividend or distribution, to that price determined by multiplying the Exercise Price in effect immediately prior to such date of determination by a fraction (i) the numerator of which will be the total
number of shares of Common Stock outstanding immediately prior to such dividend or distribution, and (ii) the denominator of which will be the total number of shares of Common Stock outstanding immediately after such dividend or distributions
(including shares of Common Stock issuable upon exercise, conversion or exchange of any Convertible Securities issued as a dividend or distribution). If the Convertible Securities issued as such dividend or distributions by their terms provided,
with the passage of time or otherwise, for any increase or decrease in the consideration payable to the Company, or any increase or decrease in the number of shares issuable upon exercise, conversion or exchange thereof, or any change of rate or
otherwise), the Exercise Price will, upon any such decrease or increase becoming effective, be reduced or increased to reflect such decrease or increase as if such decrease or increase became effective immediately prior to the issuance of the
Convertible Securities as the dividend or distribution. Any adjustment under this Section 2(c) will become effective on the record date or, if there is not record date, on the date of issuance. 
 (d) Adjustment of Number of Shares. Upon each adjustment in the Exercise Price pursuant to this Section 2, the number of
shares issuable upon exercise of this Warrant will be adjusted to the number obtained by dividing the then outstanding Aggregate Exercise Price by the Exercise Price immediately after such adjustment. 
  

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 3. Compliance With Securities Act; Transferability of Warrant. 
 (a) Legends. Any certificate for shares issued upon exercise hereof will be imprinted with a legend in substantially the form set
forth in the Notice of Exercise form attached hereto as Annex I. 
 (b) Restricted Securities. The Holder understands
that the Warrant, the Common Stock (the “Securities”), that the Holder is purchasing are characterized as “restricted securities” under the federal securities laws, inasmuch as they are being acquired from the Company in a
transaction not involving a public offering, and that under such laws and applicable regulations such securities may be resold without registration under the Securities Act of 1933, as amended (the “1933 Act”) only in certain limited
circumstances. In this connection, the Holder is familiar with Rule 144, as presently in effect, and understands the resale limitations imposed thereby and by the 1933 Act. The Holder understands Rule 144 is not currently available for the
sale of the Securities and may never be so available. 
 (c) Transferability and Negotiability of Warrant. This Warrant
may not be transferred or assigned in whole or in part, unless (i) there is then in effect a registration statement (declared effective by the Securities and Exchange Commission) and necessary state regulatory authorities) under the 1933 Act
covering such proposed disposition and such disposition is made in accordance with such registration statement; or (ii) the Holder will have notified the Company of the proposed disposition and will have furnished the Company with a brief
statement of the circumstances surrounding the proposed disposition, and if reasonably requested by the Company, the Holder will have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company that such disposition will
not require registration of such shares under the 1933 Act; provided however, no such registration or opinion will be necessary for any transfer of this Warrant: (i) in compliance with Rule 144 or Rule 144A of the 1933 Act, (ii) by
gift, will or intestate succession by the Holder to his or her spouse or lineal descendants or ancestors or any trust for any of the foregoing or (iii) pursuant to a transfer to any partner, former partner, affiliate, member or equity holder of
the Holder or the estate of any such partner, former partner, affiliate, member or equity holder of the Holder; provided that, in each of the foregoing cases, the transferee agrees in writing to be subject to the terms of this Warrant. Subject to
the provisions of this Section 3(c), title to this Warrant may be transferred in the same manner as a negotiable instrument transferable by endorsement and delivery, by execution and delivery of a completed Assignment Form attached hereto as
Annex II. 
 4. Representations and Warranties of the Holder. The Holder hereby represents and warrants that: 
 (a) Authorization. The Holder has full power and authority to enter into this Warrant, and this Warrant constitutes the valid and
legally binding obligations of the Holder, enforceable in accordance with its terms. 
 (b) Purchase Entirely for Own
Account. The Securities will be acquired for investment for the Holder’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and the Holder has no present intention of selling,
granting any participation in or otherwise distributing the same. The Holder does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participation in any of the Securities to such person or to any
third person. 
  

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 (c) Disclosure of Information. The Holder has received all the information the
Holder considers necessary or appropriate for deciding whether to purchase this Warrant. The Holder has had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering and sale of the
Securities. 
 (d) Investment Experience. The Holder is an investor in securities of companies in the development stage
and acknowledges that the Holder is able to fend for himself and bear the economic risk of its investment, including the complete loss thereof, and has such knowledge and experience in financial or business matters that the Holder is capable of
evaluating the merits and risks of the investment in the Securities. The Holder acknowledges that the Company currently is seeking investors to participate in a proposed offering of the Company’s securities, but there can be no assurances that
the Company will find financing on acceptable terms, if at all. The Holder has not been organized for the purpose of acquiring the Securities. 
 (e) Accredited Investor. The Holder is an “accredited investor” within the meaning of Rule 501 of Regulation D, as presently in effect, promulgated under the 1933 Act. 
 5. Market Stand-Off Agreement. The Holder agrees to be bound by the market stand-off agreement set forth in the Company’s Investors’
Rights Agreement (as defined in the Bridge Notes), as the same may be amended from time to time. 
 6. Replacement of Warrant. On
receipt of evidence reasonably satisfactory to the Company of the loss, theft, destruction, or mutilation of this Warrant and, in the case of loss, theft, or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and
substance to the Company or, in the case of mutilation, on surrender and cancellation of this Warrant, the Company at its expense will execute and deliver, in lieu of this Warrant, a new warrant of like tenor and amount. 
 7. Reservation of Stock. The Company covenants that during the term this Warrant is exercisable, the Company will reserve from its authorized and
unissued Common Stock and Common Stock or Series F Preferred Stock, as the case may be, a sufficient number of shares to provide for the issuance of Common Stock or Series F Preferred Stock, as the case may be, upon the exercise of this Warrant and,
if applicable, the issuance of Common Stock upon conversion of the Series F Preferred Stock and, from time to time, will take all steps necessary to amend its Restated Articles to provide sufficient reserves of shares of Common Stock or Series F
Preferred Stock, as the case may be, issuable upon exercise of the Warrant and, if applicable, Common Stock issuable upon conversion of the Series F Preferred Stock. The Company agrees that its issuance of this Warrant will constitute full authority
to its officers who are charged with the duty of executing stock certificates to execute and issue the necessary certificates for shares of Common Stock or Series F Preferred Stock upon the exercise of this Warrant. 
 8. Notices. In case: 
 (a) the Company will take a record of the holders of its Common Stock (or other stock or securities at the time receivable upon the exercise of this Warrant) for the purpose 

  

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of entitling them to receive any dividend or other distribution, or any right to subscribe for or purchase any shares of stock of any class or any other
securities, or to receive any other right, or 
 (b) of any capital reorganization of the Company, any reclassification of the
capital stock of the Company, any consolidation or merger of the Company with or into another corporation, or any conveyance of all or substantially all of the assets of the Company to another corporation, or 
 (c) the closing of an IPO or the conversion of this Warrant into a Warrant to purchase shares of Series F Preferred Stock, or 

(d) of any voluntary dissolution, liquidation of winding up of the Company, then, and in each such case, the Company will mail or cause
to be mailed to the Holder or Holders a notice specifying, as the case may be, (A) the date on which a record is to be taken for the purpose of such dividend, distribution or right, and stating the amount and character of such dividend,
distribution or right, or (B) the date on which such reorganization, reclassification, consolidation, merger, conveyance, dissolution, liquidation or winding up is to take place, and the time, if any is to be fixed, as of which the holders of
record of Common Stock (or such stock or securities at the time receivable upon the exercise of this Warrant) will be entitled to exchange their shares of Common Stock (or such other stock or securities) for securities or other property deliverable
upon such reorganization, reclassification, consolidation, merger, conveyance, dissolution, liquidation or winding up. Such notice will be mailed at least fifteen (15) days prior to the date therein specified. 
 9. Rights of Shareholders. The Holder will not be entitled to vote or receive dividends or be deemed the holder of Common Stock or any other
securities of the Company that may at any time be issuable on the exercise hereof for any purpose, nor will anything contained herein be construed to confer upon the Holder, as such, any of the rights of a shareholder of the Company or any right to
vote for the election of directors or upon any matter submitted to shareholders at any meeting thereof, or to give or withhold consent to any corporate action (whether upon any recapitalization, issuance of stock, reclassification of stock, change
of par value, or change of stock to no par value, consolidation, merger, conveyance, or otherwise) or to receive notice of meetings, or to receive dividends or subscription rights or otherwise until the Warrant will have been exercised and the
shares of Common Stock purchasable upon the exercise hereof will have been issued, as provided herein. 
 10. Fractional Shares. No
fractional shares will be issued in connection with any exercise hereunder, but in lieu of such fractional shares the Company will make a cash payment therefor upon the basis of the Exercise Price then in effect. 
 11. Assignment. This Warrant applies to, inures to the benefit of, and binds the successors and assigns of the parties hereto. Any transfer of
this Warrant will be effected only by surrender of this Warrant to the Company and reissuance of a new note to transferee. The Holder and any subsequent holder(s) of this Warrant receive this Warrant subject to the foregoing items and conditions,
and agree to comply with the foregoing terms and conditions for the benefit of the Company and any other holders. 
  

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 12. Notices. Any notice, request or other communication required or permitted hereunder will be in
writing and will be deemed to have been duly given (i) when received, if personally delivered, faxed, sent by nationally recognized courier or U.S. Mail return-receipt requested, or (ii) on the third (3rd) business day after deposit
in the U.S. Mail, if sent by first-class mail, in any such case to the address of the Holder set forth on the signature page hereto and to the Company at Alsius Corporation, 15770 Laguna Canyon Road, Suite 150, Irvine, California 92618, Attention:
President. Any party hereto may by notice so given change its address for future notice hereunder. 
 13. Warrant Register. This
Warrant is transferable only upon the books of the Company which it will cause to be maintained for such purpose. The Company may treat the registered holder of this Warrant as he, she or it appears on the Company’s books at any time as the
Holder for all purposes. 
 14. Amendment, Waiver, Etc. The terms of this Warrant may be amended or waived only upon the written
agreement of the Company and the Holder; provided, however, that during the time (and only during the time) the Bridge Notes are outstanding, the terms of this Warrant and all of the other Warrants issued by the Company in connection with the Bridge
Notes may be amended or waived upon the written agreement of the Company and the Holders of at least sixty percent (60%) of the aggregate principal amount of all Bridge Notes (the “Supermajority Holders”), whether or not the Holder of
this Warrant agrees thereto, as long as such amendment or waiver is the same for all Warrants. Any such amendment or waiver agreed to by the Company and the Supermajority Holders during the time the Bridge Notes are outstanding will be binding on
the holders of all Warrants. Amendments or waivers to which the Company and the Supermajority Holders may agree, and which will be binding on holders of all Warrants, include, but are not limited to, (i) shortening the term of the Warrants,
(ii) changing the exercise price of the Warrants, or (iii) reducing the number of shares for which the Warrants are exercisable (as long as such reduction is proportionally the same for each Warrant holder based on the shares covered by
such holder’s Warrant relative to the shares covered by all Warrants). 
 15. Heading; References. All headings used herein are
used for convenience only and will not be used to construe or interpret this Warrant. Except where otherwise indicated, all references herein to Sections refer to Sections hereof. 
 16. Severability. If any provision or set of provisions of this Warrant (or any portion thereof) is held by an arbitrator or court of competent
jurisdiction to be invalid, illegal or unenforceable for any reason whatever: (a) such provision will be limited or modified in its application to the minimum extent necessary to avoid the invalidity, illegality or unenforceability of such
provision and such modified provision will be reduced to a writing and signed by the parties hereto; (b) the validity, legality and enforceability of the remaining provisions of this Warrant will not in any way be affected or impaired thereby;
and (c) to the fullest extent possible, the provisions of this Warrant will be construed so as to give effect to the intent manifested by the provision (or portion thereof) held invalid, illegal or unenforceable. 
 17. Effect of Amendment or Waiver. Each Holder acknowledges that by the operation of Section 14 hereof, less than all of the Holders of
Warrants (or such transferees of Warrants) may effect an amendment or waiver of provisions of the Warrants and may therefore 

  

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diminish or eliminate all rights of such Holder under this Warrant even though such Holder has not consented to the amendment or waiver. 
 18. Governing Law. This Warrant will be governed by and construed in accordance with the laws of the State of California, without regards to its
conflict of laws provisions. 
 [Remainder of page intentionally left blank] 
  

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 IN WITNESS WHEREOF, the undersigned have caused this Warrant to be executed by the undersigned as of the
date first set forth above. 
  

			
	 ALSIUS CORPORATION,
 a California
corporation

		
	By:	 	  
		 	William J. Worthen
		 	President and Chief Executive Officer
	
	 HOLDER:
  
 [INVESTOR]

		
	By:	 	  
		
	Name:	 	  
		
	Title:	 	  

			
		
	Address:	 	  

			
		
	Fax:	 	  
		
	Phone:	 	  

  

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 ANNEX I 
 TO WARRANT 
 Warrant Notice of Exercise 
 Ladies/Gentlemen: 
 On this date the
undersigned,
                                        
                    , hereby acquires from Alsius Corporation, a California corporation (the “Company”), an aggregate of
                             shares of Common Stock (as defined in the Warrant) or Series F Preferred
Stock (as defined in the Warrant), as the case may be, which is exercised hereby (the “Restricted Securities”). 
 1. Investment Intent. The
undersigned represents and warrants that: 
 (a) The Restricted Securities have been acquired by the undersigned for investment and not with
a view to the sale or other distribution thereof within the meaning of the Securities Act of 1933, as amended (the “1933 Act”) and the undersigned has no present intention of selling or otherwise disposing of all or any portion of the
Restricted Securities. 
 (b) The undersigned has acquired the Restricted Securities for the undersigned’s own account and no one else
has any beneficial ownership in the Restricted Securities. 
 2. Restrictions on Transfer. The undersigned understands that: 
 (a) In reliance upon the representations and warranties set forth herein, the Restricted Securities have not been registered with the Securities and
Exchange Commission, and accordingly may not be offered, sold or otherwise transferred except in compliance with the 1933 Act (including any exemptions from registration thereunder); 
 (b) The undersigned must bear the economic risk of the undersigned’s investment in the Restricted Securities indefinitely unless and until the
Restricted Securities are registered pursuant to the 1933 Act or, in the opinion of counsel in form and substance satisfactory to the Company, an exemption from the registration requirement is available; 
 (c) The undersigned cannot be assured that any exemption from the registration requirement will be available should the undersigned desire to transfer
the Restricted Securities, and, therefore, the undersigned may not be able to dispose of or otherwise transfer the Restricted Securities, under the circumstances, in the amounts, or at the time proposed by the undersigned; and 
 (d) Rule 144 promulgated under the 1933 Act, which provides for certain limited, routine sales of unregistered securities, is not presently
available with respect to the Restricted Securities, and the Company is under no obligation to furnish the information that might be necessary to enable the undersigned to sell any of the Restricted Securities under Rule 144. 
 3. Legend and Stop-Transfer Orders. The undersigned understands that, if required by applicable federal securities laws at the date of issuance of the Restricted
Securities, certifies or other instruments representing any of the Restricted Securities acquired by the undersigned will 

 
bear a legend substantially similar to the following, in addition to any other legends required by federal or state laws, or by any contractual agreement
binding upon the undersigned with respect to the Restricted Securities: 
 THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED OR
QUALIFIED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE, AND MAY BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED AND QUALIFIED PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS
OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT REQUIRED OR IF THE COMPANY OTHERWISE SATISFIES ITSELF THAT REGISTRATION IS
NOT REQUIRED. 
 The undersigned agrees that, to ensure and enforce compliance with the restrictions imposed by applicable law and those
referred to in the foregoing legend, or elsewhere herein, the Company may issue appropriate “stop transfer instructions to its transfer agent, if any, with respect to any certificate or other instrument representing Restricted Securities, or if
the Company transfers its own securities, that it may make appropriate notation to the same effect in the Company’s records. 
 Notwithstanding the legend above, no registration statement or opinion of counsel will be necessary for any transfer of Restricted Securities: (i) in compliance with Rule 144 or Rule 144A of the 1933 Act, (ii) by gift, will
or intestate succession by the Holder to his or her spouse or lineal descendants or ancestors or any trust for any of the foregoing or (iii) pursuant to a transfer to any partner, former partner, affiliate or the estate of any such partner of
the Holder; provided that, in each of the foregoing cases, the transferee agrees in writing to be subject to the terms of the Warrant. 
  

			
	  
	 (Printed name if entity)
 (Signature of
Individual)
  
 (Please fill in and sign below only if entity):

		
	By:	 	  
		 	        (Signature)

			
		
	Printed name:	 	  

			
		
	Its:	 	  
		
	Date:	 	  

 ANNEX II 
 TO WARRANT 
 ASSIGNMENT FORM FOR ALSIUS CORPORATION WARRANT 
 To assign the foregoing Warrant, execute this form and supply required information. Do not use this form to exercise the Warrant to purchase shares.

 PLEASE NOTE: The Warrant has not been registered under the Securities Act of 1933, as amended, or under the applicable state
securities laws. The Warrant is subject to restrictions on transferability and resale and may not be transferred or resold except as permitted under the Warrant. 
 FOR VALUE RECEIVED, the foregoing Warrant for the purchase of capital stock of Alsius Corporation and all rights evidenced thereby are hereby assigned to 
  

			
	Name of assignee:	  	  

			
		
	Address of assignee:	  	  

			
		
		  	  

					
			
	Date:	  	  	  	

			
		
	Assigning Holder’s Name:	  	  

			
		
	Assigning Holder’s Signature:	  	  

			
		
	Assigning Holder’s Address:	  	  

			
		
		  	  

 The name and signature of the assigning Holder must be exactly the same as the Holder’s name appears on the
face of the assigned warrant, without alteration or enlargement or any change whatever. Officers of corporations and those acting in fiduciary or their representative capacity should file with this Assignment proper evidence of their authority to so
act.Form of 8% Unsecured Convertible Promissory Note

 Exhibit 10.19 
 THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE, AND MAY BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED AND QUALIFIED
PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT
REQUIRED OR IF THE COMPANY OTHERWISE SATISFIES ITSELF THAT REGISTRATION IS NOT REQUIRED. 
 THIS 8% UNSECURED CONVERTIBLE PROMISSORY NOTE (THIS
“NOTE”) IS SUBORDINATED TO THE COMPANY’S REPAYMENT OBLIGATIONS TO OXFORD FINANCE CORPORATION. THE TERMS OF REPAYMENT UNDER THIS NOTE SHALL BE SUBJECT TO THE TERMS OF A SUBORDINATION AGREEMENT AMONG THE COMPANY, OXFORD FINANCE
CORPORATION AND THE UNDERSIGNED. 
 ALSIUS CORPORATION, 
 a California corporation 
 8% UNSECURED CONVERTIBLE PROMISSORY NOTE

 Due December 31, 2006 
  

			
	Principal Amount $            	  	April 13, 2006

 FOR VALUE RECEIVED, ALSIUS CORPORATION, a California corporation (the “Company”), hereby
promises to pay to the undersigned holder (the “Holder”), or its registered assigns, the principal amount advanced to the Company hereunder, up to the total principal amount stated above. 
 1. (a) Bridge Financing. This 8% Unsecured Convertible Promissory Note (the “Note”) is part of a series of notes of like tenor which are
being issued by the Company on or about the date hereof in connection with a bridge financing of the Company of up to $6 million (such notes are collectively referred to as the “Bridge Notes”). In the event that, after the initial issuance
of the Bridge Notes, the Company elects to increase the bridge financing by issuing additional convertible promissory notes having the same terms as this Note, except for a later issuance date, then the issuance of such additional notes will require
the approval of the holders of two-thirds of the principal amount of all Bridge Notes (the “Supermajority Holders”) and, after such approval, such notes will also be considered Bridge Notes for purposes hereof. The rights of
repayment of the holder of this Note and the holders of all other Bridge Notes are subordinated to the right of Oxford Finance Corporation, a lender to the Company, to be repaid all principal, interest, expenses and other amounts owed to such
lender, currently 

 
approximately $4.3 million. Under Section 23 hereof, the Holder agrees to sign a subordination agreement reasonably acceptable to Oxford Finance
Corporation. 
 (b) Maturity; Repayment. Repayment of this Note will be made in lawful money of the United
States of America at the address of the Holder set forth on the signature page hereto, or at such other place as the Holder may designate in writing. Unless earlier converted pursuant to Section 2 hereof, the principal advanced hereunder will
be due and payable on the earliest to occur of (i) December 31, 2006 (the “Maturity Date”), (ii) an Event of Default (as hereinafter defined) or (iii) the closing of a Sale Transaction. Interest will accrue on the unpaid
principal sum at a rate of eight percent (8%) per annum. Prepayment of principal and accrued interest may be made in whole or in part from time to time without penalty only with the consent of the Supermajority Holders, provided that prepayment
may only be made on this Note if at the same time prepayment is made on all Bridge Notes, with payment on each Bridge Note made pro rata in proportion to the original principal amount of such Bridge Note relative to the aggregate principal amount of
all Bridge Notes. 
 (c) Issuance of Promissory Notes or Other Securities with Superior Terms. If, after the date
hereof and prior to the earlier of the Maturity Date or the full repayment or conversion of the Bridge Notes, the Company issues additional promissory notes or other securities (“Senior Securities”) that provide superior rights to the
holders of such Senior Securities than the Bridge Notes, then the Bridge Notes shall be deemed automatically amended, without the need for any action on the part of Company or the Holder, as of the date of the issuance of the Senior Securities to
confer such additional rights upon all holders of Bridge Notes. At the written request of the Supermajority Holders, the Company will exchange the Bridge Notes for amended and restated Bridge Notes or such other documents as are necessary to
evidence the additional rights granted to the holders of Senior Securities. 
 2. (a) Automatic Conversion Upon IPO. If, after the
date hereof and prior to the earlier of the Maturity Date or the full repayment or conversion of the Bridge Notes, the Company closes an underwritten public offering of its Common Stock (an “IPO”), then the entire principal amount of this
Note and accrued interest (calculated through the date that is ten (10) days prior to the closing of the IPO) will be converted automatically, without the need for any action on the part of Company or the Holder, into unregistered shares of
Common Stock of the Company concurrently with the closing of the IPO. The number of shares of Common Stock issuable upon conversion of this Note will be calculated by dividing the total of the principal amount of and accrued interest on this Note
(calculated through the date set forth above in this Section 2(a)) then outstanding by 80% of the per share public offering price stated on the front cover of the final prospectus for the IPO (before deduction of any underwriting commissions,
expenses or other amounts). The Company will give the Holder notice of the intended closing of an IPO, including the public offering price, provided that the failure to give such notice will not affect the automatic conversion of this Note. In order
to receive certificates representing the Common Stock, the Holder must cause the original of this Note to be delivered to the Company, or if lost, stolen or destroyed, an affidavit and, if reasonably requested by the Company, a reasonable indemnity
as to the lost, stolen or destroyed original of this Note. Then, the Company will cause one or more stock certificates evidencing the Holder’s ownership of the number of conversion shares into which the principal amount of, and interest accrued
on, this Note has been 

  

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converted to be delivered promptly to the Holder or as directed by the Holder. From and after the IPO, this Note will represent only the right to receive
shares of Common Stock. 
 (b) Repayment or Conversion Upon Sale Transaction. If, after the date hereof and prior to
the full repayment or conversion of the Bridge Notes, the Company closes a Sale Transaction (as defined below), then the entire principal amount of this Note and accrued interest (calculated through the date that is ten (10) days prior to the
closing of the Sale Transaction) shall become immediately due and payable and will be repaid at the closing of such Sale Transaction in an amount equal to 150% of such principal amount and accrued interest (the “Sale Repayment”). The form
of repayment of this Note in connection with a Sale Transaction will be in the same form of consideration (i.e., cash and/or stock) as is received by the other shareholders of the Company in the Sale Transaction. The valuation of the acquirer’s
stock or any other non-cash consideration used to repay the Note, will be made by mutual agreement of the Company and the Supermajority Holders, or absent such agreement, by an experienced professional appraiser selected by mutual agreement of the
Company and the Supermajority Holders. The Company will give the Holder prior written notice of its intention to complete a Sale Transaction, stating the principal terms of the transaction; however, the failure to give such notice will not affect
the repayment terms of this Note. “Sale Transaction” means (i) any sale of all or substantially all of the assets of the Company, and (ii) any stock purchase, consolidation, merger, exchange or other transaction or series of
related transactions pursuant to which holders of the outstanding voting securities of the Company immediately prior to such consolidation, merger, exchange or other transaction or series of transactions fail to hold equity securities representing a
majority of the voting power of the Company or surviving entity immediately following such stock purchase, consolidation, merger, exchange or other transaction or series of transactions. A Sale Transaction will not include a change of ownership of
the Company (whether or not greater than fifty percent (50%)) that results from the sale of newly issued securities of the Company for cash in a financing or series of related financings. The acquirer in any Sale Transaction may require the
Holder to surrender the original of this Note, or if lost, stolen or destroyed, an affidavit and, if reasonably requested by the Company, a reasonable indemnity as to the lost, stolen or destroyed original of this Note, in order to receive the Sale
Repayment. 
 (c) Conversion at Maturity. If, on or before the Maturity Date, this Note is not repaid in full and there
has not been an IPO or Sale Transaction, then the principal amount of this Note and accrued interest (calculated through the Maturity Date) will be converted automatically on the Maturity Date, without the need for any action by the Company or the
Holder, into shares of the Company’s current Series F Preferred Stock (the “Series F Preferred Stock”). The number of shares of Series F Preferred Stock issuable upon conversion of this Note will be calculated by dividing the total of
the principal amount then outstanding of and accrued interest on this Note (calculated through the Maturity Date) by the current $3.00 price per share of the Series F Preferred Stock (as adjusted for stock splits, consolidations, recapitalizations
and the like that may occur after the date hereof). In order to receive certificates representing the Series F Preferred Stock issuable upon conversion of this Note, the Holder must cause the original of this Note to be delivered to the Company, or
if lost, stolen or destroyed, an affidavit and, if reasonably requested by the Company, a reasonable indemnity as to the lost, stolen or destroyed original of this Note. Then, the Company will cause one or more stock certificates evidencing the
Holder’s ownership of the number of conversion shares into which the principal 

  

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amount of, and interest accrued on, this Note has been converted to be delivered promptly to the Holder or as directed by the Holder. From and after the
Maturity Date, this Note will represent only the right to receive shares of Series F Preferred Stock. 
 3. Default. If any of the
following events (hereafter called “Events of Default”) occurs: 
 (a) If the Company defaults in the payment of any
principal or accrued interest due under this Note within fifteen (15) days of the date the same becomes due and payable, whether at maturity or by acceleration or otherwise; or 
 (b) If the Company makes a general assignment for the benefit of creditors; or 
 (c) If the Company files a voluntary petition in bankruptcy, or becomes insolvent or adjudicated bankrupt, or files any petition or answer
seeking any reorganization, arrangement, composition, readjustment, liquidation, dissolution or similar relief under the present or any future federal bankruptcy act or other applicable federal, state or other statute, law or regulation, or files
any answer admitting the material allegation of a petition filed against the Company in such proceeding, or seeks or consents to or acquiesces in the appointment of any trustee, receiver or liquidator of the Company or of all or any substantial part
of the properties of the Company, or the Company commences the winding up or the dissolution or liquidation of the Company; or 
 (d) If, within sixty (60) days after a court of competent jurisdiction has entered an order, judgment or decree approving any complaint or petition against the Company seeking reorganization, dissolution or similar relief under the
present or any future federal bankruptcy act or other applicable federal, state or other statute, law or regulation, such order, judgment or decree has not been dismissed or stayed pending appeal, or if, within sixty (60) days after the
appointment, without the consent or acquiescence of the Company, of any trustee, receiver or liquidator of the Company or of all or any substantial part of the properties of the Company, such appointment has not been vacated or stayed pending
appeal, or if, within sixty (60) days after the expiration of any such stay, such appointment has not been vacated; or 
 (e) In the event the Company (i) redeems, purchases or otherwise acquires for value, any share or shares of its equity securities other than shares issued to officers, directors, employees and consultants of the Company pursuant to
agreements giving the Company a right or duty to repurchase such shares upon termination of employment with or service to the Company, (ii) declares or pays any dividends on or declares or makes any other distribution (other than a dividend
payable on capital stock solely in shares of capital stock) on account of any of its equity securities or sets apart any sum for any such purpose, or (iii) repays any of the Bridge Notes other than a repayment made with the consent of the
Supermajority Holders concurrently made on all Bridge Notes, with payment on each Bridge Note made pro rata in proportion to the principal amount of such Bridge Note relative to the aggregate principal amount of all Bridge Notes; 
 then, and in each and every such case, the Supermajority Holders, but not any individual holder of Bridge Notes, may by written notice to
the Company declare all 

  

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amounts under this Note and all other Bridge Notes to be forthwith due and payable (except that, in the case of an Event of Default under either
Section 3(b), Section 3(c) or Section 3(d) hereof, this Note will become immediately due and payable without notice, and in the case of a default under Section 3(e)(iii) hereof, the Holder of this Note may by written notice
declare all amounts under this Note due and payable without needing the approval of the Supermajority Holders) and thereupon the balance will become so due and payable, without presentation, protest or further demand or notice of any kind, all of
which are hereby expressly waived. The Company will give prompt written notice to the Holder of the occurrence or the approval by the Company or its Board of Directors of any and all of the foregoing events. 
 4. Representations, Warranties and Covenants of the Company. The Company hereby represents, warrants and covenants that: 
 (a) Organization, Good Standing, Qualification. The Company is a corporation duly organized, validly existing and in good standing
under the laws of the State of California, has all requisite corporate power and authority to own and operate its properties and assets and to carry on its business as now conducted and as proposed to be conducted, to execute and deliver this Note
and the Warrant to be issued in connection with the Bridge Notes (the “Warrant”), to issue and sell the Common Stock, or Series F Preferred Stock, as the case may be, issuable upon conversion of this Note, and the Common Stock issuable
upon conversion thereof, and the Common Stock issuable upon exercise of the Warrants (collectively, the “Securities”), and to carry out the provisions of this Note and the Warrant. The Company is qualified to transact business as a foreign
corporation and is in good standing under the laws of California and under the laws of each jurisdiction where its ownership, lease or operation of property or the conduct of its business requires such qualification, except to the extent that
failure to so qualify would not have a material adverse effect on the Company. 
 (b) Authorization. All corporate
action on the part of the Company, its officers, directors and shareholders necessary for the authorization, execution and delivery of this Note and the Warrant, the performance of all obligations of the Company hereunder and thereunder at the
closing of the bridge financing of which this Note is a part (the “Closing”) and the authorization, issuance (or reservation for issuance), sale and delivery of the Securities has been taken or will be taken prior to the Closing (except
for the authorization of additional equity needed for the conversion of the Notes, as contemplated by Section 5(f) hereof), and this Note and the Warrant constitute valid and legally binding obligations of the Company, enforceable in accordance
with their respective terms except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors’ rights generally, (b) as limited by laws
relating to the availability of specific performance, injunctive relief or other equitable remedies. 
 (c)
Capitalization. The authorized capital of the Company consists of: 
 (i) Preferred Stock. 11,538,655 shares of
Preferred Stock (the “Preferred Stock”), 718 shares of which have been designated Series A Preferred Stock, all of which are currently issued and outstanding; 148 shares of which have been designated Series B Preferred Stock, all of which
are currently issued and outstanding; 1,582,546 shares of which have been designated Series C-D Preferred Stock, 1,582,026 

  

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shares of which are currently issued and outstanding; 1,422,435 shares of Series E Preferred Stock, all of which are currently issued and outstanding; and
8,532,808 shares of which have been designated Series F Preferred Stock, 8,319,141 shares of which are issued and outstanding. 
 (ii) Common Stock. 16,000,000 shares of Common Stock of which 56,984 shares are issued and outstanding. Except for (i) the conversion privileges of the Series A, Series B, Series C-D, Series E and Series F Preferred Stock;
(ii) warrants to purchase 414,554 shares of Common Stock; (iii) warrants to purchase 116,667 shares of Series F Preferred Stock; (iv) the rights provided in paragraph 2.3 of the Tenth Amended and Restated Investor Rights Agreement,
dated September 2, 2004, among the Company, certain investors and other specified holders named therein (the “Investors’ Rights Agreement”); (v) rights granted in the Second Amended and Restated Right of First Refusal and
Co-Sale Agreement, dated September 2, 2004, among the Company, certain investors and other specified holders named therein; and (vi) 1,923,701 shares issuable pursuant to options granted under the Company’s stock incentive plans or
otherwise. The Company has reserved 2,100,000 shares of its Common Stock for purchase upon exercise of options granted or available for grant under the 2004 Plan. Except as set forth in the Eighth Amended and Restated Articles of Incorporation (the
“Restated Articles”), the Investor Rights Agreement and the Shareholders Agreement, dated September 2, 2004, among the Company, certain investors and other specified holders named therein, the Company is not a party or subject to any
agreement or understanding, and, to the best of the Company’s knowledge, there is no agreement or understanding between any persons that affects or relates to the voting or giving of written consents with respect to any security or the voting
by a director of the Company. 
 (iii) Securities Law Compliance. The outstanding shares of Common Stock and Preferred
Stock have been issued in accordance with the registration or qualification provisions of the Securities Act of 1933, as amended (the “1933 Act”) and any relevant state securities laws or pursuant to valid exemptions therefrom and have
been duly authorized and validly issued and are fully paid and nonassessable, and have been issued in compliance with applicable federal and state securities laws. 
 (d) Valid Issuance. The Securities, when issued, sold and delivered in accordance with the terms of this Note and the Warrant for
the consideration expressed herein and therein, will be duly and validly issued, fully paid and nonassessable, and will be free and clear of any pledges, liens and encumbrances in favor of the Company and of restrictions on transfer other than
restrictions on transfer under this Note, the Warrant and under applicable state and federal securities laws as presently in effect. 
 (e) Offering. Subject in part to the truth and accuracy of the Holder’s representations set forth in this Note and the Warrant, the offer, sale and issuance of this Note, the Common Stock or Series F Preferred Stock, as the case
may be, as contemplated by this Note and the issuance of the Common Stock to be issued upon conversion thereof, the Warrant and the Common Stock issuable upon exercise of the Warrant, are exempt from the registration requirements of the 1933 Act,
and neither the Company nor any authorized agent acting on its behalf will take any action hereafter that would cause the loss of such exemption. 
  

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 (f) Compliance With Other Instruments. The execution, delivery and performance by
the Company of this Note and the Warrant, the issuance (or reservation for issuance) of the Securities, and the consummation of the transactions contemplated hereby and thereby will not (i) result in any violation or default of any provision of
its Restated Articles or Bylaws, (ii) result in a violation or default in any material respect of any provision of any mortgage, agreement, instrument or contract to which it is a party or by which it is bound or, to the best of its knowledge,
of any federal or state judgment, order, writ, decree, statute, rule or regulation applicable to the Company, or (iii) constitute, with or without the passage of time or giving of notice, an event that results in the creation of any material
lien, charge or encumbrance upon any assets of the Company or the suspension, revocation, impairment, forfeiture or nonrenewal of any material permit, license, authorization or approval applicable to the Company, its business or operations, or any
of its assets or properties. 
 (g) Reservation of Stock. The Company covenants that in the event this Note is
convertible into Series F Preferred Stock, the Company will use its best efforts to (i) reserve from its authorized and unissued Series F Preferred Stock, and Common Stock issuable upon conversion thereof, a sufficient number of shares to
provide for the issuance of Series F Preferred Stock upon the conversion of this Note or (ii) take all necessary steps to amend its Restated Articles to provide sufficient reserves of shares of Series F Preferred Stock issuable upon conversion
of this Note, and shares of its Common Stock for issuance on conversion thereof. 
 (h) Amendment to Investors’ Rights
Agreement. Concurrent with the execution and delivery of this Note, the Company and certain of the holders of the Bridge Notes have amended that certain Tenth Amended and Restated Investors’ Rights Agreement, dated September 2, 2004,
among the Company and the investors named therein (the “Investors’ Rights Agreement”) to provide that all securities issuable upon conversion of this Note and all securities issuable upon exercise of the Warrants shall constitute
“Registrable Securities” for purposes of such agreement. 
 5. Representations, Warranties and Covenants of the Holder. The
Holder hereby represents and warrants that: 
 (a) Authorization. The Holder has full power and authority to enter into
this Note, and this Note constitutes the valid and legally binding obligations of the Holder, enforceable in accordance with its terms. 
 (b) Purchase Entirely for Own Account. The Securities will be acquired for investment for the Holder’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part
thereof, and the Holder has no present intention of selling, granting any participation in or otherwise distributing the same. The Holder does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant
participation in any of the Securities to such person or to any third person. 
 (c) Disclosure of Information. The
Holder has received all the information the Holder considers necessary or appropriate for deciding whether to purchase the Securities. The Holder has had an opportunity to ask questions and receive answers from the Company regarding the terms and
conditions of the offering and sale of the Securities. 
  

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 (d) Investment Experience. The Holder is an investor in securities of companies in
the development stage and acknowledges that the Holder is able to fend for himself and bear the economic risk of its investment, including the complete loss thereof, and has such knowledge and experience in financial or business matters that the
Holder is capable of evaluating the merits and risks of the investment in the Securities. The Holder acknowledges that the Company currently is seeking investors to participate in a proposed offering of the Company’s securities, but there can
be no assurances that the Company will find financing on acceptable terms, if at all. The Holder has not been organized for the purpose of acquiring the Securities. 
 (e) Accredited Investor. The Holder understands the definition of, and represents that the Holder is, an “accredited
investor” as defined in Rule 501 of Regulation D, as presently in effect, promulgated under the 1933 Act. 
 (f) Covenant of the Holder. The Holder agrees to execute and deliver such documents and agreements and to vote either at a meeting of shareholders or by written consent as may be reasonably requested from time to time by the Company
to carry out the obligations hereunder and under the Warrant, including, but not limited to, all shareholder consents required in its capacity as a Holder to increase the number of authorized shares of Series F Preferred Stock and/or Common Stock.

 6. Restricted Securities. The Holder understands that the Securities that the Holder is purchasing are characterized as
“restricted securities” under the federal securities laws, inasmuch as they are being acquired from the Company in a transaction not involving a public offering, and that under such laws and applicable regulations such securities may be
resold without registration under the 1933 Act only in certain limited circumstances. In this connection, the Holder is familiar with Rule 144, as presently in effect, and understands the resale limitations imposed thereby and by the 1933 Act. The
Holder understands Rule 144 is not currently available for the sale of the Securities and may never be so available. 
 7. Further
Limitations on Disposition. Without in any way limiting the representations set forth above, the Holder further agrees not to make any disposition of all or any portion of the Securities (other than the valid exercise or conversion thereof in
accordance with their respective terms) unless and until: 
 (a) There is then in effect a registration statement under the
1933 Act covering such proposed disposition, and such disposition is made in accordance with such registration statement; or if requested by the Company, the Holder has furnished the Company with an opinion of counsel, reasonably satisfactory to the
Company, that such disposition will not require registration of such Securities under the 1933 Act. 
 (b) Notwithstanding the
foregoing, no investment representation letter or opinion of counsel will be required for any transfer of Securities (i) in compliance with Rule 144 or Rule 144A of the 1933 Act, (ii) by gift, will or intestate succession by the
Holder to his or her spouse or lineal descendants or ancestors or any trust for any of the foregoing or (iii) pursuant to a transfer to any partner, former partner, affiliate, member or equity holder of the Holder or the estate of any such
partner, former partner, affiliate, member or equity holder of the Holder; 

  

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provided that, in each of the foregoing cases, the transferee agrees in writing to be subject to the terms of this Note. In addition, if the Holder of any
Securities delivers to the Company an unqualified opinion of counsel that no subsequent transfer of such Securities will require registration under the 1933 Act, the Company will, upon such contemplated transfer, promptly deliver new
documents/certificates for such Securities that do not bear the legend set forth in Section 8(a) hereof. 
 8. Legends. It is
understood that the certificates evidencing the Securities may bear one or more of the following legends: 
 (a) The following
legend under the 1933 Act: 
 “THESE SECURITIES HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR
THE SECURITIES LAWS OF ANY STATE, AND MAY BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED AND QUALIFIED PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL
REASONABLY SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT REQUIRED OR IF THE COMPANY OTHERWISE SATISFIES ITSELF THAT REGISTRATION IS NOT REQUIRED.” 
 (b) Any legend required by state securities laws. 
 The Company agrees to remove promptly, upon the request of the Holder of Securities issued upon conversion of this Note, the legend set
forth in Section 8(a) hereof from the documents/certificates for such Securities upon full compliance with this Note, Rules 144 and 145 under the 1933 Act and any other applicable provisions of the 1933 Act. 
 9. Market Stand-Off Agreement. The Holder agrees to be bound by the market stand-off agreement set forth in the Company’s Investors’
Rights Agreement, as the same may be amended from time to time. 
 10. Assignment. This Note applies to, inures to the benefit of, and
binds the successors and assigns of the parties hereto. Any transfer of this Note will be effected only by surrender of this Note to the Company and reissuance of a new note to the transferee. The Holder and any subsequent holder(s) of this Note
receive this Note subject to the foregoing items and conditions, and agree to comply with the foregoing terms and conditions for the benefit of the Company and any other holders. 
 11. Expenses. Irrespective of whether the Closing is effected, the Company and the Holder will be solely responsible for paying its own costs and
expenses with respect to the negotiation, execution, delivery and performance of this Note and the Warrant; provided, however, that the Company agrees to pay reasonable fees and expenses of one counsel to all holders of Bridge Notes actually
incurred. 
  

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 12. Notices. Any notice, request or other communication required or permitted hereunder will be in
writing and will be deemed to have been duly given (i) when received, if personally delivered, faxed, sent by nationally recognized courier or U.S. Mail return-receipt requested, or (ii) on the third business day after deposit in the U.S.
Mail, if sent by first-class mail, in any such case to the address of the Holder set forth on the signature page hereto and to the Company at Alsius Corporation, 15770 Laguna Canyon Road, Suite 150, Irvine, California 92619, Attention: President.
Any party hereto may by notice so given change its address for future notice hereunder. 
 13. No Shareholder Rights. Nothing
contained in this Note will be construed as conferring upon the Holder or any other person the right to vote or to consent or to receive notice as a shareholder in respect of meetings of shareholders for the election of directors of the Company or
any other matters or any rights whatsoever as a shareholder of the Company; and no dividends will be payable or accrued in respect of this Note or the capital stock obtainable hereunder until, and only to the extent that, this Note will have been
converted. 
 14. Note Register. This Note is transferable only upon the books of the Company which it will cause to be maintained for
such purpose. The Company may treat the registered holder of this Note as he, she or it appears on the Company’s books at any time as the Holder for all purposes. 
 15. Loss, Etc., of Note. Upon receipt of evidence satisfactory to the Company of the loss, theft, destruction or mutilation of this Note, and of indemnity reasonably satisfactory to the Company if lost, stolen
or destroyed, and upon surrender and cancellation of this Note if mutilated, the Company will execute and deliver to the Holder a new note of like date, tenor and denomination. 
 16. Amendment, Waiver, Etc. The terms of this Note may be amended or waived only upon the written agreement of the Company and the Holder;
provided, however, that the terms of this Note and all of the Bridge Notes may be amended or waived upon the written agreement of the Company and the Supermajority Holders, whether or not the Holder of this Note agrees thereto, as long as such
amendment or waiver is the same for all Bridge Notes. Any such amendment or waiver agreed upon by the Company and the Supermajority Holders will be binding on the holders of all Bridge Notes. Amendments or waivers to which the Company and the
Supermajority Holders may agree, and which will be binding on holders of all Bridge Notes, include, but are not limited to, (i) extending the maturity date, (ii) converting principal and accrued interest on the Bridge Notes in whole or in
part into equity securities of the Company, whether or not an IPO has occurred, or (iii) changing the terms of repayment of the Bridge Notes upon a Sale Transaction, including reducing the premium payable; provided, however, that no amendment
to the Bridge Notes shall be effective if such amendment violates any of the terms of the Subordination Agreement (as hereinafter defined). 
 17. Heading; References. All headings used herein are used for convenience only and will not be used to construe or interpret this Note. Except where otherwise indicated, all references herein to Sections refer to Sections hereof.

  

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 18. Governing Law. This Note will be governed by and construed in accordance with the laws of the
State of California, without regard to its conflicts of laws provisions. 
 19. Severability. If any provision or set of provisions of
this Note (or any portion thereof) is held by an arbitrator or court of competent jurisdiction to be invalid, illegal or unenforceable for any reason whatever: (a) such provision will be limited or modified in its application to the minimum
extent necessary to avoid the invalidity, illegality or unenforceability of such provision and such modified provision will be reduced to a writing and signed by the parties hereto; (b) the validity, legality and enforceability of the remaining
provisions of this Note will not in any way be affected or impaired thereby; and (c) to the fullest extent possible, the provisions of this Note will be construed so as to give effect to the intent manifested by the provision (or portion
thereof) held invalid, illegal or unenforceable. 
 20. Miscellaneous. The Company hereby waives presentment, demand, notice of
nonpayment, protest and all other demands and notices in connection with the delivery, acceptance, performance or enforcement of this Note. If an action is brought for collection under this Note, the Company will pay all costs of collection actually
incurred by a representative of the holders of a majority of the principal amount of all Bridge Notes (the “Majority Holders”), including, but not limited to, the reasonable attorneys’ fees of a single counsel for all holders of
Bridge Notes selected by the Majority Holders. 
 21. Warrant. As additional consideration for the issuance of this Note, the Holder
will receive the warrant attached hereto as Exhibit A. 
 22. Effect of Amendment or Waiver. Each Holder acknowledges
that, by the operation of Section 16 hereof, less than all of the Holders of Bridge Notes (or such transferees of Bridge Notes) may effect an amendment or waiver of provisions of the Bridge Notes and may therefore diminish or eliminate rights
of such Holder under this Note even though such Holder has not consented to the amendment or waiver. 
 23. Oxford Subordination. The
Holder agrees to sign such reasonable subordination agreement (the “Subordination Agreement”) as is required by Oxford Finance Corporation and is reasonably acceptable to the Supermajority Holders, to memorialize the subordination by the
holders of Bridge Notes of their right to be repaid to the repayment rights of Oxford Finance Corporation under its loan agreements with the Company. 
 [Signatures on Following Page] 
  

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 IN WITNESS WHEREOF, the undersigned have caused this 8% Unsecured Convertible Promissory Note to be
executed by the undersigned as of the date first set forth above. 
  

			
	 ALSIUS CORPORATION,
 a California
corporation

		
	By:	 	  
		 	William J. Worthen
		 	President and Chief Executive Officer
	
	 HOLDER:
  
 [INVESTOR]

		
	By:	 	  
		
	Name:	 	  
		
	Title:	 	  

			
		
	Address:	 	  

			
		
	Fax:	 	  
		
	Phone:	 	  

  

 -12- 

 EXHIBIT A 
 WARRANT

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