Document:

Employment Agreement between Sangamo and Dr. Geoff Nichol

 Exhibit 10.4 
 EMPLOYMENT AGREEMENT 
 Employment Agreement (the “Agreement”)
made effective as of the 17th day of June 2011 (the “Commencement Date”), by and between Sangamo BioSciences, Inc., a Delaware corporation (the “Company”) and Dr. Geoff Nichol (the “Executive”). 

R E C I T A L S 
 The Board of Directors (the “Board”) has elected Executive to serve as the Company’s Executive Vice President Research and Development pursuant to the terms of this Agreement and Executive
desires to accept the position. 
 NOW, THEREFORE, the parties agree as follows: 

1. Position. 
 The Board has elected Executive to the full-time position of the Company’s Executive Vice President Research and Development and Executive has accepted this position. In his role as Executive Vice
President Research and Development, Executive will report to the Company’s Chief Executive Officer. 
 2.
Compensation. 
 Executive will be paid as compensation for his services a base salary at the annual rate of $425,000,
or such higher rate as the Board may determine from time to time. The salary shall be payable in accordance with the standard payroll procedures of the Company. The annual compensation specified in this Section 2, together with any increases in
such compensation that may be granted from time to time, is referred to in this Agreement as “base salary.” 
 3.
Annual Performance Bonus. 
 Executive shall be eligible to receive a bonus of up to forty percent (40%) of his
base salary for his performance each calendar year. This bonus shall be paid not later than February 28 of the year following the year for which it is being paid based upon the achievement of certain individual and Company performance criteria
as agreed upon by the Board (or the Compensation Committee of the Board) and Executive. The determination of Executive’s performance in relation to the performance criteria and the amount of the bonus shall be in the sole discretion of the
Board (or the Compensation Committee of the Board). 
 4. Sign-On Bonus. 

Executive shall on the Commencement Date be paid a sign-on bonus in the amount of $150,000 (the “Sign-On Bonus”). Should
Executive’s employment be terminated by the Company for Cause (as defined below), or should Executive voluntarily terminate his employment other than for Good Reason (as defined below), at any time prior to the second (2nd) anniversary of
the Commencement Date, then, in either case, Executive shall at the time of such termination repay the Sign-On Bonus to the Company. 

 5. Benefits. 

Executive will be entitled to the employee benefits generally provided to other executive officers of the Company. Under the
Company’s vacation policy, you will have 10 sick days, 15 vacation days and 10 Company holidays per year. 
 6.
Equity. 
 (a) The Board (or a committee of the Board) shall grant Executive a stock option to purchase 300,000 shares
of the Company’s Common Stock with an exercise price per share equal to the fair market value of the Company’s Common Stock on the date of grant (the “Option”) under the Company’s 2004 Stock Incentive Plan (the
“Plan”). The grant of the Option shall be not later than the second business day after the commencement of Executive’s employment. The Option will be evidenced by the standard stock option agreement under the Plan and will be subject
to the terms and conditions of that agreement and the Plan, with one-quarter of the Option shares vesting twelve (12) months from the date of grant and the remainder vesting in equal monthly installments for thirty-six (36) months
thereafter, provided Executive remains a full-time employee during these time periods. Vesting of the Option and any subsequent equity grants will cease upon termination of Executive’s employment by either party for any reason, provided
however, in the event of the termination of Executive’s employment by the Company without “Cause” (as hereafter defined) or by Executive for “Good Reason” (as hereafter defined), in either case, within twelve
(12) months of the Change in Control (as hereafter defined), Executive shall vest in full with respect to the Option and any other equity incentive award then held by Executive. 

(b) For purposes of this Agreement, “Change in Control” shall mean a change in ownership or control of the Company effected
through any of the following transactions: 
 (i) a merger, consolidation or other reorganization approved by the
Company’s stockholders, unless securities representing more than fifty percent (50%) of the total combined voting power of the voting securities of the successor corporation are immediately thereafter beneficially owned, directly or
indirectly and in substantially the same proportion, by the persons who beneficially owned the Company’s outstanding voting securities immediately prior to such transaction, 

(ii) a stockholder-approved sale, transfer or other disposition of all or substantially all of the Company’s assets in
complete liquidation or dissolution of the Company, or 
 (iii) the closing of any transaction or series of related
transactions pursuant to which any person or any group of persons comprising a “group” within the meaning of Rule 13d-5(b)(1) of the 1934 Act (other than the Company or a person that, prior to such transaction or series of related
transactions, directly or indirectly controls, is controlled by or is under common control with, the Company) becomes directly or indirectly the beneficial owner (within the meaning of Rule 13d-3 of the 1934 Act) of securities possessing (or
convertible into 

  
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or exercisable for securities possessing) more than fifty percent (50%) of the total combined voting power of the Company’s securities (as measured in terms of the power to vote with
respect to the election of Board members) outstanding immediately after the consummation of such transaction or series of related transactions, whether such transaction involves a direct issuance from the Company or the acquisition of outstanding
securities held by one or more of the Company’s existing stockholders. 
 (d) In the event of any conflict with the terms
of the stock option agreement or the Plan, and this Agreement, this Agreement will control. 
 7. Employment Period

 Executive’s employment with the Company pursuant to this Agreement shall commence upon execution of this Agreement and
shall continue until terminated by either party (the “Employment Period”). Executive’s employment may be terminated by either party upon thirty (30) days written notice to the other party. Upon such termination, Executive will be
entitled to the severance benefits described herein. 
 8. Severance Benefits. 

(a) If Executive’s employment is terminated by the Company for Cause, or by Executive without Good Reason, or upon Executive’s
death, then Executive will receive his unpaid salary and benefits (including accrued, but unused vacation time) earned up to the effective date of his termination and nothing else. 

(b) If Executive incurs a Separation from Service (as hereafter defined) because his employment is terminated by the Company without
“Cause” or by Executive with “Good Reason” in either case within twelve (12) months following a Change in Control, Executive shall be entitled to receive the following benefits: 

(i) The Company shall immediately pay to Executive the amounts described in Section 8(a) above. 

(ii) The Company shall pay in cash an amount equal to (A) Executive’s annual base salary then in effect plus
(B) Executive’s target bonus for the year in which the termination occurs as a severance payment. Such severance payment shall be paid over a twelve (12) month period in a series of successive equal installments. The first such
payment shall be made within the sixty (60)-day period measured from the date of the Executive’s Separation from Service (as hereafter defined) as a result of termination specified in this Section 8(b), provided that the General Release
has been delivered by Executive pursuant to Section 8(f) below and is effective and enforceable following the expiration of the maximum review and revocation periods applicable to that release under law. However, should such sixty (60)-day
period span two taxable years, then the first such payment shall be made during the portion of that sixty (60)-day period that occurs in the second taxable year. The remaining installments shall be made in accordance with the Company’s regular
payroll schedule for its salaried employees. The severance payments under this Section 8(b) shall be treated as a right to a series of separate payments for purposes of Section 409A of the Internal Revenue Code of 1986, as amended (the
“Code). 

  
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 (iii) The Company shall pay a lump sum cash payment in the amount of $25,000 within the
sixty (60)-day period measured from the date of the Executive’s Separation from Service as a result of termination specified in this Section 8(b), provided that the General Release has been delivered by Executive pursuant to
Section 8(f) below and is effective and enforceable following the expiration of the maximum review and revocation periods applicable to that release under law. However, should such sixty (60)-day period span two taxable years, then such payment
shall be made during the portion of that sixty (60)-day period that occurs in the second taxable year. 
 (c) If
Executive’s employment is terminated by the Company without “Cause” or by Executive with “Good Reason” in the absence of a Change in Control or more than 12 months after a Change in Control, Executive will be entitled to
receive the following benefits: 
 (i) The Company shall immediately pay to Executive the amounts described in
Section 8(a) above. 
 (ii) The Company shall pay in cash an amount equal to Executive’s annual base salary then in
effect as a severance payment. Such severance payment shall be paid over a twelve (12) month period in a series of successive equal installments. The first such payment shall be made within the sixty (60)-day period measured from the date of
the Executive’s Separation from Service (as hereafter defined) as a result of termination specified in this Section 8(c), provided that the General Release has been delivered by Executive pursuant to Section 8(f) below and is
effective and enforceable following the expiration of the maximum review and revocation periods applicable to that release under law. However, should such sixty (60)-day period span two taxable years, then the first such payment shall be made during
the portion of that sixty (60)-day period that occurs in the second taxable year. The remaining installments shall be made in accordance with the Company’s regular payroll schedule for its salaried employees. The severance payments under this
Section 8(c) shall be treated as a right to a series of separate payments for purposes of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code). 

(iii) The Company shall pay a lump sum cash payment in the amount of $25,000 within the sixty (60)-day period measured from the date of
the Executive’s Separation from Service as a result of termination specified in this Section 8(c), provided that the General Release has been delivered by Executive pursuant to Section 8(f) below and is effective and enforceable
following the expiration of the maximum review and revocation periods applicable to that release under law. However, should such sixty (60)-day period span two taxable years, then such payment shall be made during the portion of that sixty (60)-day
period that occurs in the second taxable year. 

  
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 (d) For purposes of this Agreement, “Cause” shall be defined as: 

(i) conviction of a felony, or any other crime against or involving the Company; 

(ii) a proven act of fraud, dishonesty or misappropriation committed by Executive with respect to the Company; 

(iii) willful or reckless misconduct by Executive that materially affects the Company or any of its officers, directors, employees,
clients, partners, insurers, subsidiaries, parents, or affiliates; 
 (iv) a material breach of this Agreement or the
Proprietary Information and Assignment of Inventions Agreement between Executive and the Company (“Proprietary Information Agreement”). 
 The foregoing is an exclusive list of the acts or omissions that shall be considered “Cause” for the termination of Executive’s employment. 

(e) For purposes of this Agreement, “Good Reason” shall be defined as one or more of the following conditions arising without
Executive’s written consent: 
 (i) a material diminution in Executive’s base compensation; or 

(ii) a material relocation of Executive’s principal place of business, with a relocation of more than fifty (50) miles to be
deemed material for such purposes; 
 (iii) a material diminution in Executive’s duties, responsibilities or authority;

 (iv) prior to a Change of Control, a requirement that Executive report to a supervisor other than the Company’s Chief
Executive Officer; or 
 (v) a material breach of this Agreement by the Company. 

In order for a termination of employment to be for Good Reason, Executive must provide written notice to the Board of the existence of
one or more conditions described above and his intent to resign for Good Reason hereunder within a period not to exceed thirty (30) of the initial existence of the condition. Following his providing this notice, the Company shall be provided a
period of at least thirty (30) days during which to remedy the condition. Executive shall continue to receive the compensation and benefits provided by this Agreement during the cure period and if the condition is not cured during such period,
then at the end of such period Executive’s employment shall cease and Executive will become entitled to the severance benefits described above. If the condition is cured, Executive shall not be deemed to have “Good Reason” to
terminate his employment. 
 (f) Notwithstanding the foregoing, in order to receive any severance payments or benefits under
this Section 8, Executive must first execute and deliver to the Company, within thirty (30) days (or forty-five (45) days if such longer period is required under applicable law) after the effective date of termination of employment, a
general settlement and 

  
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release agreement in substantially the form attached hereto as Exhibit A (a “General Release”), and such General Release must become effective and enforceable in accordance with its
terms following the expiration of any applicable revocation period under federal or state law. If such General Release is not executed and delivered to the Company within the applicable thirty (30) (or forty-five (45))-day period hereunder or does
not otherwise become effective and enforceable in accordance with its terms, then no severance benefits will provided Executive under Section 8(b) or 8(c). 
 (g) For purposes of this Agreement, “Separation from Service” shall mean Executive’s cessation of Employee status and shall be deemed to occur at such time as the level of the bona fide
services Executive is to perform in Employee status (or as a consultant or other independent contractor) permanently decreases to a level that is not more than twenty percent (20%) of the average level of services Executive rendered in Employee
status during the immediately preceding thirty-six (36) months (or such shorter period for which Executive may have rendered such service). Any such determination as to Separation from Service, however, shall be made in accordance with the
applicable standards of the Treasury Regulations issued under Section 409A of the Code. For purposes of determining whether Executive has incurred a Separation from Service, Executive will be deemed to continue in “Employee” status
for so long as he remains in the employ of one or more members of the Employer Group, subject to the control and direction of the employer entity as to both the work to be performed and the manner and method of performance. “Employer
Group” means the Company and any other corporation or business controlled by, controlling or under common control with, the Company as determined in accordance with Sections 414(b) and (c) of the Code and the Treasury Regulations
thereunder, except that in applying Sections 1563(1), (2) and (3) for purposes of determining the controlled group of corporations under Section 414(b), the phrase “at least 50 percent” shall be used instead of “at
least 80 percent” each place the latter phrase appears in such sections and in applying Section 1.414(c)-2 of the Treasury Regulations for purposes of determining trades or businesses that are under common control for purposes of
Section 414(c), the phrase “at least 50 percent” shall be used instead of “at least 80 percent” each place the latter phrase appears in Section 1.4.14(c)-2 of the Treasury Regulations. 

9. Full-time Services to the Company. 
 As a full-time executive employee, the Company requires that Executive devotes his full business time, attention, skills and efforts to the duties and responsibilities of his position. However, Executive
will not be precluded from providing services to non-profit organizations or sitting on the board of directors of companies identified in writing to the Company prior to the execution of this Agreement or approved by the Board or the Compensation
Committee of the Board, so long as such services will not otherwise interfere with Executive’s ability to satisfactorily fulfill his duties and responsibilities to the Company. 

10. Tax Withholdings. 
 Any and all cash compensation and other benefits paid to Executive under this Agreement shall be subject to all applicable tax withholding requirements, and the Company shall make such other deductions as
may be required and/or allowed by applicable law and/or as authorized in writing by Executive. 

  
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 11. Section 409A Delayed Commencement of Benefits. 

(a) The severance and other benefits under this Agreement are intended, where possible, to comply with the “short term deferral
exception” and the “involuntary separation pay exception” to Code Section 409A. Accordingly, the provisions of this Agreement applicable to the severance benefits described in Section 8 and the determination of the
Executive’s Separation from Service due to termination of the Executive’s employment without Cause or the Executive’s resignation for Good Reason shall be applied, construed and administered so that those payments and benefits qualify
for one or both of those exceptions, to the maximum extent allowable. However, to the extent any payment or benefit to which the Executive becomes entitled under this Agreement is deemed to constitute an item of deferred compensation subject to the
requirements of Code Section 409A, the provisions of this Agreement applicable to that payment or benefit shall be applied, construed and administered so that such payment or benefit is made or provided in compliance with the applicable
requirements of Code Section 409A. In addition, should there arise any ambiguity as to whether any other provisions of this Agreement would contravene one or more applicable requirements or limitations of Code Section 409A and the Treasury
Regulations thereunder, such provisions shall be interpreted, administered and applied in a manner that complies with the applicable requirements of Code Section 409A and the Treasury Regulations thereunder. 

(b) Notwithstanding any provision in this Agreement the contrary, no payment or distribution under this Agreement which constitutes an
item of deferred compensation under Section 409A of the Code and becomes payable by reason of the Executive’s termination of employment with the Company will be made to the Executive until the Executive incurs a Separation from Service in
connection with such termination of employment. For purposes of this Agreement, each amount to be paid or benefit to be provided to the Executive shall be treated as a separate identified payment or benefit for purposes of Section 409A of the
Code. In addition, no payment or benefit which constitutes an item of deferred compensation under Section 409A of the Code and becomes payable by reason of the Executive’s Separation from Service will be made to the Executive prior to the
earlier of (i) the first day of the seven (7)-month following the date of such Separation from Service or (ii) the date of the Executive’s death, if the Executive is deemed at the time of such Separation from Service to be a specified
employee (as determined pursuant to Code Section 409A and the Treasury Regulations thereunder) and such delayed commencement is otherwise required in order to avoid a prohibited distribution under Code Section 409A(a)(2). Upon the
expiration of the applicable deferral period, all payments and benefits deferred pursuant to this Section 11(b) (whether they would have otherwise been payable in a single sum or in installments in the absence of such deferral) shall be paid or
provided to the Executive in a lump sum on the first day of the seventh (7th) month after the date of the Executive’s Separation from Service or, if earlier, the first day of the month immediately following the date the Company receives
proof of the Executive’s death. Any remaining payments or benefits due under this Agreement will be paid in accordance with the normal payment dates specified herein. 
 12. Arbitration. 
 Any dispute, controversy, or claim, whether contractual
or non-contractual, between Executive and the Company, unless mutually settled, shall be resolved by 

  
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binding arbitration in accordance with the Employment Arbitration Rules of Judicial Arbitration and Mediation Service (“JAMS”). Executive and the Company each agree that before
proceeding to arbitration, they will mediate disputes before the JAMS by a mediator approved by the JAMS. If mediation fails to resolve the matter, any subsequent arbitrator shall be conducted by an arbitration approved by the JAMS and mutually
acceptable to Executive and the Company. All disputes, controversies, and claims shall be conducted by a single arbitrator. If Executive and the Company are unable to agree on the mediator or the arbitrator, then the JAMS shall select the
mediator/arbitrator. The resolution of the dispute by the arbitrator shall be final, binding, non-appealable, and fully enforceable by a court of competent jurisdiction under the Federal Arbitration Act. The arbitration award shall be in writing and
shall include a statement of the reasons for the award. The arbitration shall be held in San Francisco, California. The Company shall pay all JAMS, mediation, and arbitrator’s fees and costs, irrespective of who raised the claim and the outcome
of arbitration. 
 13. Indemnification. During the Employment Period Executive shall be a covered officer under the
Company’s directors and officers liability insurance. As required under California law, the Company will indemnify Executive for all necessary expenditures or losses incurred by Executive in direct consequence of the discharge of his duties or
his obedience to the directions of the Company. 
 14. Severability. 

If any provision of this Agreement as applied to any party or to any circumstance should be adjudged by a court of competent
jurisdiction (or determined by the arbitrator) to be void or unenforceable for any reason, the invalidity of that provision shall in no way affect (to the maximum extent permissible by law) the application of such provision under circumstances
different from those adjudicated by the court or determined by the arbitrator, the application of any other provision of this Agreement, or the enforceability or invalidity of this Agreement as a whole. Should any provision of this Agreement become
or be deemed invalid, illegal or unenforceable in any jurisdiction by reason of the scope, extent or duration of its coverage, then such provision shall be deemed amended to the extent necessary to conform to applicable law so as to be valid and
enforceable or, if such provision cannot be so amended without materially altering the intention of the parties, then such provision will be stricken, and the remainder of this Agreement shall continue in full force and effect. 

15. Miscellaneous. 
 Executive acknowledges and agrees that in deciding to sign this Agreement he has not relied on any representations, promises or commitments concerning his employment, whether spoken or in writing, made to
him by any representative of the Company, except for what is expressly stated in this Agreement, and the Proprietary Information Agreement. This Agreement can only be changed by another written agreement signed by Executive and an authorized
representative of the Company and, to be effective, must specifically state that it is intended to alter or modify this Agreement. Except as provided for herein, this Agreement and the Proprietary Information Agreement consist of the entire
agreement between the parties and supersede and replace any prior verbal or written agreements between Executive and the Company. 

  
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 This Agreement shall be construed and interpreted in accordance with the laws of the State
of California. Each provision of this agreement is severable from the others, and if any provision hereof shall be to any extent unenforceable, it and the other provisions shall continue to be enforceable to the full extent allowable, as if such
offending provision had not been a part of this Agreement. 
  

			
	SANGAMO BIOSCIENCES, INC.
		
	 By:        
	 	 /s/ Edward O. Lanphier II

		 	 Edward O. Lanphier II
 Chief
Executive Officer

	
	DR. GEOFF NICHOL, EXECUTIVE
		
		 	 /s/ Dr. Geoff Nichol

  
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 EXHIBIT A 
 GENERAL SETTLEMENT AND RELEASE AGREEMENT 
 PURSUANT TO SECTION 8(F) OF THE EMPLOYMENT
AGREEMENT BETWEEN SANGAMO BIOSCIENCES, INC. AND DR. GEOFF NICHOL, EXECUTION OF A GENERAL SETTLEMENT AND RELEASE AGREEMENT, IN SUBSTANTIALLY THE SAME FORM AS THIS EXHIBIT A IS A CONDITION TO MR. NICHOL’S RECEIPT OF CERTAIN PAYMENTS AND BENEFITS
PURSUANT TO SECTION 8 OF SUCH AGREEMENT. THIS DOCUMENT IS INTENDED AS A FORM OF THE GENERAL SETTLEMENT AND RELEASE AGREEMENT AND MUST BE FINALIZED BY SANGAMO BIOSCIENCES, INC. PRIOR TO EXECUTION. 

  
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 GENERAL SETTLEMENT AND RELEASE AGREEMENT 

This General Settlement and Release Agreement (the “Agreement”) is by and between Sangamo BioSciences, Inc., for itself and
for all of its affiliated, related, parent and direct and indirect subsidiary companies, joint venturers and partnerships, successors and permitted assigns and each of them (collectively, the “Company”), on the one hand, and Dr. Geoff
Nichol for himself, and his agents, representatives, heirs and assigns (the “Executive”), on the other hand. 
 1.
Payments. In full and complete consideration for the Executive’s promises and undertaking set forth in this Agreement, following the eighth (8th) day following receipt by the Company of a fully executed General Settlement and Release Agreement from the
Executive, the Company will provide the Executive the consideration, if any, to which the Executive is entitled pursuant to the Employment Agreement between the parties, dated June 17, 2011, at the times specified in Section 8 of that
Agreement unless the signature on this Agreement is revoked pursuant to Section 8 below. 
 2. Release of Known and Unknown
Claims. 
 (a) It is understood and agreed by the parties to this Agreement that in consideration of the mutual promises
and covenants contained in this Agreement, and after consultation with counsel, the Executive irrevocably and unconditionally releases and forever discharges the Company, its parent, subsidiary and affiliated companies, and all of their past and
present officers, directors, employees, agents and assigns (collectively, the “Released Parties”), from any and all causes of action, claims, actions, rights, judgments, obligations, damages, demands, accountings or liabilities of whatever
kind or character, which the Executive may have against the Company or any of the Released Parties, or any of them, by reason of or arising out of, touching upon or concerning the Executive’s employment, separation of his employment and
reapplication for employment with the Company, or any statutory claims, or any and all other matters of whatever kind, nature or description, whether known or unknown, occurring prior to the date of the execution of this Agreement. The Executive
acknowledges that this release of claims specifically includes, but is not limited to, any and all claims for fraud; breach of contract; breach of the implied covenant of good faith and fair dealing; inducement of breach; interference with
contractual rights; wrongful or unlawful discharge or demotion; violation of public policy; sexual assault and battery; invasion of privacy; intentional or negligent infliction of emotional distress; intentional or negligent misrepresentation;
conspiracy; defamation; unlawful effort to prevent employment; discrimination or harassment on the basis of age, race, color, sex, gender, national origin, ancestry, religious creed, physical or mental disability, medical condition, marital status,
sexual orientation, genetic information or characteristics, or any other basis protected by applicable law; any claim under: Title VII of the Civil Rights Act of 1964 (“Title VII”); the Americans With Disabilities Act of 1990
(“ADA”); the Age Discrimination in Employment Act of 1967 (“ADEA”); the Employee Retirement Income Security Act of 1974 (“ERISA”); the Equal Pay Act of 1963 (“EPA”); the Fair Labor Standards Act
(“FLSA”); the Consolidated Omnibus Budget Reconciliation Act (“COBRA”); the Worker Adjustment and Retraining 

  
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Notification Act (“WARN”); the Occupational Safety and Health Act (“OSHA”); the Lilly Ledbetter Fair Pay Act of 2009 (“Fair Pay Act”); the California Fair Employment
and Housing Act (“FEHA”); the California Labor Code; and CalOSHA, or any other wrongful conduct, based upon events occurring prior to the date that this Agreement is executed by the Executive. Notwithstanding anything to the contrary
herein, this Agreement shall not release the Executive’s right, if any, to claims he may have for: (i) indemnification pursuant to the bylaws of the Company or insurance policies of the Company, for any claims arising out of the
Executive’s conduct as an employee or officer of the Company during his employment, (ii) unemployment, state disability and/or paid family leave insurance benefits pursuant to the terms of applicable state law, (iii) continuation of
existing participation in Company-sponsored group health benefit plans under COBRA and/or an applicable state counterpart law, (iv) any benefit entitlements that are vested as of the Executive’s termination date pursuant to the terms of a
Company-sponsored benefit plan governed by ERISA, (v) stock and/or vested option shares pursuant to the written terms and conditions of the Executive’s existing stock option grants and agreements, existing as of his termination date,
(vi) violation of any federal, state or local statutory and/or public policy right or entitlement that, by applicable law, is not waivable, and (vii) any wrongful act or omission occurring after the date the Executive signs this Agreement.

 (b) The Executive represents and warrants that he has not assigned or subrogated any of his rights, claims or causes of
action, including any claims referenced in this Agreement, or authorized any other person or entity to assert such claims on his behalf, and he agrees to indemnify and hold harmless the Company and each of the Released Parties against any assignment
of said rights, claims and/or causes of action. 
 3. Waiver of Unknown Claims. 

(a) The Executive does hereby expressly waive and relinquish all rights and benefits afforded to him under law, and does so understanding
and acknowledging the significance and consequences of such a waiver. 
 (b) Releases of Unknown Claims/Waiver of Civil Code
Section 1542. The parties agree that this Agreement is a full and final release of any and all claims and the Executive expressly waives the benefit of Section 1542 of the California Civil Code, which provides: 

“A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF
EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM OR HER MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR.” 

(c) The Executive acknowledges and understands that he is being represented in this matter by counsel, and he expressly acknowledges and
agrees that this Agreement is intended to include in its effect, without limitation, all claims which he does not know or suspect to exist at the time of the execution of this Agreement, and that this Agreement contemplates the extinguishment of
those claims. 

  
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 (d) The Executive acknowledges and agrees that he may later discover facts different from or
in addition to those he now knows or believes to be true in entering into this Agreement. The Executive agrees to assume the risk of the possible discovery of additional or different facts, including facts which may have been concealed or hidden,
and agrees that this Agreement shall remain effective regardless of such additional or different facts. The Executive further acknowledges and agrees that neither the Company nor any of the other Released Parties had any duty to disclose any fact to
him prior to the execution of this Agreement. 
 4. Government Agency Claims Exception. Nothing in Section 2 above, or
elsewhere in this Agreement, prevents or prohibits the Executive from filing a claim with a government agency, such as the U.S. Equal Employment Opportunity Commission, that is responsible for enforcing a law on behalf of the government. However,
the Executive understands that he may only seek and receive non-personal forms of relief through any such claim unless otherwise provided by law. 
 5. Non-Admission of Liability. The Executive expressly recognizes that this Agreement shall not in any way be construed as an admission by the Company or any of the other Released Parties of
any unlawful or wrongful acts whatsoever against the Executive or any other person or entity. The Company and each of the Released Parties expressly denies any violation of any policy or procedure, or of any state or federal law or regulation. The
Company and each of the Released Parties also specifically denies any liability to or wrongful acts against the Executive, or any other person, on the part of themselves or any other employees or agents of the Company. This Agreement shall not be
admissible in any proceeding as evidence of or any admission by the Company of any violation of any law or regulation or wrongful act. This Agreement may, however, be introduced in any proceeding to enforce this Agreement. 

6. No Filing of Claims. The Executive specifically represents that he has no pending complaints or charges against the Company or any of
the other Released Parties with any state or federal court or any local, state or federal agency, division or department based on any events occurring prior to the date of execution of this Agreement. 

7. Advice of Counsel. The Executive acknowledges that he has been given twenty-one days (21) to seek the advice of counsel and to
consider the effects of this Agreement upon his legal rights (the “Consideration Period”). To the extent that the Executive has signed the Agreement without obtaining the advice of counsel or before expiration of the Consideration Period,
the Executive acknowledges that he has done so voluntarily with a full understanding of the Agreement and its effect upon his legal rights. Any discussion between the Executive and the Company or any of the Released Parties concerning the terms and
conditions of this Agreement does not extend the Consideration Period. 
 8. Revocation Period. The Executive
acknowledges that he has been informed that, after he signs this Agreement, he has the right to revoke his signature for a period of seven days (7) from the date that he signs the Agreement. To be effective, the revocation must be in writing,
signed by the Executive, and delivered to Vice President of Human Resources at 501 Canal Boulevard, Point Richmond Technology Center, Richmond, California 94804 before the close of business on the seventh day (7th) day following the date the Executive signs this Agreement. The
Executive acknowledges and agrees that the Company has no obligation to comply with the terms of this Agreement until the Revocation Period has expired without revocation, at which time this Agreement will become effective and enforceable.

  
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 9. Nondisparagement. The Executive agrees that he will not disparage the Company or any of the
Released Parties, or their products, services, officers, directors, employees, with any written or oral statement and the Company agrees that it will not disparage the Executive. 
 10. Confidentiality. The Executive consents and agrees that he will not, at any time, disclose the existence of this Agreement, the terms of his severance benefits and/or the alleged facts
or circumstances giving rise to any actual or alleged claims to any person, firm, company, association, or entity or the press or media for any reason or purpose whatsoever, other than to his attorney, his immediate family and to his accountant or
financial advisor for tax purposes. If the Executive is served with any subpoena, court order, or other legal process seeking disclosure of any such information, the Executive shall promptly send to the Company, within forty-eight (48) hours,
via facsimile at (510) 970-        , such subpoena, court order, or other legal process so that the Company may exercise any applicable legal remedies. The Executive agrees and acknowledges that a
violation of this paragraph by the Executive shall be a material breach of this Agreement. 
 11. Delivery of Documents. The
Executive represents and warrants that he has not removed any documents, records or other information, including any such documents, records or information that are or were electronically stored, from the premises of the Company. The Executive
acknowledges that such documents, records and other information are the exclusive property of the Company or its subsidiaries or affiliates. 

12. Remedies For Breach Of This Agreement. 
 (a) Injunctive Relief. In the event of a breach of the provisions of this Agreement, the Executive agrees that any remedy at law for any breach or threatened breach of the provisions of such
paragraphs and the covenants set forth therein, will be inadequate and, accordingly, each party hereby stipulates that the other is entitled to obtain injunctive relief for any such breaches or threatened breaches (without the necessity of posting a
bond). The injunctive relief provided for in this paragraph is in addition to, and is not in limitation of, any and all other remedies at law or in equity otherwise available to the applicable party. 

(b) Remedies Cumulative. The remedies in this paragraph are not exclusive, and the parties shall have the right to pursue any
other legal or equitable remedies to enforce the terms of this Agreement. 
 (c) Governing Law; Consent to Jurisdiction.
This Agreement shall be deemed to be a contract made under, and shall be construed in accordance with, the laws of the State of California, without giving effect to conflict of laws principles thereof. All questions concerning the construction,
validity, and interpretation of this Agreement shall be governed by and construed in accordance with the domestic laws of the State of California, without giving effect to any choice of law or conflict of law provision that would cause the
application of the laws of any jurisdiction other than the State of California. Each of the parties hereby irrevocably and unconditionally consents to submit to the exclusive jurisdiction of the courts of the State of

  
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California or the United States District Court for the Northern District of California for any litigation, proceeding or action arising out of or relating to this Agreement (and agrees not to
commence any litigation, proceeding or action relating thereto except in such courts). Each of the parties hereby irrevocably and unconditionally waives any objection to the laying of venue of any litigation, proceeding or action arising out of this
Agreement or thereby in the courts of the State of California or the United States District Court for the Northern District of California and hereby further irrevocably and unconditionally waives and agrees not to plead or claim in any such court
that any such litigation, proceeding or action brought in any such court has been brought in an inconvenient forum. 
 13.
Counsel. The parties hereby acknowledge that they have had the reasonable opportunity to consult with attorneys of their own choice concerning the terms and conditions of this Agreement, that they have read and understand this
Agreement, that they are fully aware of the contents of this Agreement and that they enter into this agreement freely and knowingly and with a full understanding of its legal effect. 
 14. Entire Agreement. This is the entire agreement between the Executive and the Company with respect to the subject matter hereof and the Agreement supersedes any previous negotiations,
agreements and understandings. The Executive acknowledges that he has not relied on any oral or written representations by the Company (or its counsel) or any of the other Released Parties to induce him to sign this Agreement, other than the terms
of this Agreement. No modifications of this Agreement can be made except in writing signed by the Executive and the Company. 
 15.
Section 409A. It is the intention of the parties that the provisions of this Agreement comply with the requirements of Section 409A of the Internal Revenue Code (“Section 409A”) and the Treasury Regulations
thereunder. Accordingly, to the extent there is any ambiguity as to whether one or more provisions of this Agreement would otherwise contravene the applicable requirements or limitations of Section 409A, then those provisions shall be
interpreted and applied in a manner that does not result in a violation of the applicable requirements or limitations of Section 409A and the Treasury Regulations thereunder. In no event may the Executive, directly or indirectly, designate the
calendar year of a payment. 
 16. Severability. If any provision of this Agreement is held to be illegal, invalid or
unenforceable under existing or future laws effective during the term of this Agreement, such provisions shall be fully severable, the Agreement shall be construed and enforced as if such illegal, invalid or unenforceable provision had never
comprised a part of this Agreement, and the remaining provisions of this Agreement shall remain in full force and effect and shall not be affected by the illegal, invalid or unenforceable provision or by its severance from this Agreement.
Furthermore, in lieu of such illegal, invalid or unenforceable provision, there shall be added automatically as part of this Agreement a provision as similar in terms to such illegal, invalid or unenforceable provision as may be possible and be
legal, valid and enforceable. 
 17. Ambiguities. Attorneys for both parties have participated in the negotiation of this
Agreement and, thus, it is understood and agreed that the general rule that ambiguities are to be construed against the drafter shall not apply to this Agreement. In the event that any language of this Agreement is found to be ambiguous, each party
shall have an opportunity to present evidence as to the actual intent of the parties with respect to any such ambiguous language. 

  
 15 

 18. Waiver. No waiver by any party of any breach of any term or provision of this Agreement
shall be a waiver of any preceding, concurrent or succeeding breach of this Agreement or of any other term or provision of this Agreement. No waiver shall be binding on the part of, or on behalf of, any other party entering into this Agreement.

 19. Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, all of
which together shall constitute one and the same instrument. 
 THE SIGNATORIES HAVE CAREFULLY READ THIS ENTIRE AGREEMENT. ITS CONTENTS HAVE
BEEN FULLY EXPLAINED TO THEM BY THEIR ATTORNEYS. THE SIGNATORIES FULLY UNDERSTAND THE FINAL AND BINDING EFFECT OF THIS AGREEMENT. THE ONLY PROMISES MADE TO ANY SIGNATORY ABOUT THIS AGREEMENT, AND TO SIGN THIS AGREEMENT, ARE CONTAINED IN THIS
AGREEMENT. THE SIGNATORIES ARE SIGNING THIS AGREEMENT VOLUNTARILY. 
 PLEASE READ CAREFULLY. 

THIS SETTLEMENT AGREEMENT AND GENERAL RELEASE 
 INCLUDES A RELEASE OF KNOWN AND UNKNOWN CLAIMS AND OF ANY 
 RIGHTS OR
CLAIMS ARISING UNDER THE AGE DISCRIMINATION IN 
 EMPLOYMENT ACT OF 1967 

IN WITNESS WHEREOF, the parties have executed this General Settlement and Release 

Agreement on the dates set forth below. 

 

			
	SANGAMO BIOSCIENCES, INC.:
	
	  

		
	DATE:	 	  

	
	EXECUTIVE:
	
	  

		
	DATE:	 	  

  
 16Amendment to Employment Agreement

 Exhibit 10.1 
 AMENDMENT TO EMPLOYMENT AGREEMENT 
 WHEREAS, Terrence A. Duffy
(“Executive”) and CME Group Inc. (“CME”) have entered into an employment agreement, originally dated as of November 9, 2010 (the “Agreement”); and 

WHEREAS, the parties wish to amend the Agreement to clarify the applicability of certain provisions thereof in connection with CME’s
equity program. 
 NOW THEREFORE, the Agreement is hereby amended in the following manner, effective as of the date set forth
below. 
 1. The following is hereby substituted for clause (ii) of subsection 6(a) of the Agreement: 

(ii) all stock option, SAR, restricted stock, restricted stock unit, performance share, or performance stock unit awards, as those terms
are defined in the Plan, granted after the Effective Date under the Plan or a successor plan (“New Agreement Awards”) will be subject to subsection 6(i). 
 2. The last sentence of subsection 6(a) of the Agreement is hereby deleted. 
 3. The following is
hereby substituted for clause (ii) of subsection 6(b) of the Agreement: 
 (ii) all New Agreement Awards will be subject to
subsection 6(i) and 
 4. The third sentence of subsection 6(b) of the Agreement is hereby deleted. 

5. The following is hereby substituted for subsection 6(d)(3) of the Agreement: 
 (3) all New Agreement Awards will be subject to subsection 6(i); and 
 6. The following is hereby
substituted for third and fourth sentences of subsection 6(e) of the Agreement: 
 In addition, if Executive is employed on the
last day of the Agreement Term, then all New Agreement Awards will at that time be subject to the provisions of subsection 6(i) and his termination for any reason after the last day of the Agreement Term shall otherwise be treated as a termination
under this subsection 6(e). 
 7. The following Section 6(i) is hereby added to the Agreement: 

 

	(i)	If Executive’s employment terminates during the Agreement Term by reason of death, disability under subsection 6(b), or termination without Cause under subsection
6(d), or if Executive is employed by CME on the last day of the Agreement Term and his employment terminates after the last day of the Agreement Term for any reason, then: 

(1) Any Service Requirement applicable to any outstanding Full Value New Agreement Award (including without limitation any
Performance-Based New Agreement Award) that has not been satisfied before the Vesting Date will be deemed satisfied on that date, and distribution with respect to such awards will be made to Executive promptly after the Vesting Date (as those terms
are defined below). However, any Full Value New Agreement Awards that, on the Vesting Date, remain subject to vesting based upon the 

  
 1 

 
attainment of Performance Requirements (“Performance-Based New Agreement Awards”) shall remain outstanding and eligible to vest following termination and shall fully vest and settle
based upon the attainment of the applicable performance goals as and when determined by the CME Compensation Committee. “Service Requirement” means a vesting contingency based solely on the completion of a period of continued service
(including vesting based on the circumstances of termination of service), and “Performance Requirement” means a vesting contingency other than a Service Requirement. “Full Value New Agreement Award” means a New Agreement Award in
the form of a restricted stock, restricted stock unit, performance share, or performance stock unit award as those terms are defined in the Plan. “Vesting Date” is the date Executive’s employment terminates during the Agreement Term
by reason of death, disability under subsection 6(b), or termination without Cause under subsection 6(d), or if Executive is employed by CME on the last day of the Agreement Term, the last day of the Agreement Term. 

(2) Any Service Requirement applicable to any outstanding New Agreement Stock Right Award that has not been satisfied before the Vesting
Date will be deemed satisfied on that date, and all outstanding New Agreement Stock Right Awards not previously exercisable will become exercisable on that date. If Executive is employed on the last day of the Agreement Term or if his termination
date would constitute a Vesting Date, the New Agreement Stock Right Award will remain exercisable for 48 months after his date of termination (but not beyond the maximum term of the New Agreement Stock Right Award). “New Agreement Stock Right
Award” means a New Agreement Award that is in the form of a stock option or SAR award as those terms are defined in the Plan. 
  

	(ii)	Notwithstanding any other provision of this Agreement to the contrary, Performance-Based New Agreement Awards shall be in the form of restricted stock and as of the
date the target annual New Agreement Awards opportunity is established by the CME Compensation Committee shall not exceed 25% of Executive’s target annual New Agreement Awards opportunity. 

 

	(iii)	The provisions of this subsection 6(i) will remain in effect after the end of the Term. 

 The Agreement is hereby modified as set forth above, effective as of April 6, 2011. 
  

			
	CME Group Inc.
	
	     /s/ Alex J. Pollock

	By:	 	    Alex J. Pollock
		 	    Chairman of the Compensation Committee of
		 	    CME Group Inc.
	
	Executive
	
	     /s/ Terrence A. Duffy

	By:	 	    Terrence A. Duffy

  
 2

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