Document:

Regulations of the Board of Directors of Daiichi

 Exhibit 4.3 

 (TRANSLATION) 
  
 DAIICHI PHARMACEUTICAL CO., LTD. 
 REGULATIONS OF THE BOARD OF DIRECTORS 
  

	Article 1.	(Purpose) 

  
 The matters pertaining to the Board of Directors shall be governed by these Regulations as well as laws and ordinances or the Articles of Incorporation.

  

	Article 2.	(Authority and Responsibility of the Board of Directors) 

  
 The Board of Directors shall determine the Company’s business operations and shall supervise the performance of Directors. 
  

	Article 3.	(Organization) 

  
 The Board of Directors shall consist of all Directors. 
  

	Article 4.	(Rendering of Opinions by the Corporate Auditors)  

  
 Each of the Corporate Auditors may attend meetings of the Board of Directors and state his/her opinions thereat. 
  

	Article 5.	(Hearing of Opinions of Persons Other Than Directors and Corporate Auditors) 

  
 The Board of Directors may, whenever it deems necessary, request a consultant, advisor or any person who is in charge of the
relevant matters to attend a meeting of the Board of Directors and hear his/her opinion or explanation thereat. 
  

	Article 6.	(Kind of Meetings and Time of Holding Thereof) 

  
 1.      Meetings of the Board of Directors shall consist of ordinary meetings and extraordinary meetings. 
  
 2.      An ordinary meeting of the Board of Directors shall be
held once a month in principle, and an extraordinary meeting of the Board of Directors may be held from time to time whenever deemed necessary. 
  

	Article 7.	(Convocation and Chairperson) 

  
 1.      Meetings of the Board of Directors shall be convened and presided by the Chairperson of the Board; provided, however, that when the
Board of Directors does not elect the Chairperson of the Board, the President and Director shall convene such meetings and act as the chairperson thereat. 
  
 2.      When the Chairperson of the Board is unable to act, the President and Director, the Executive Vice President and Directors, a Senior
Managing Director or a Managing Director, in this order of priority, shall act in place of the Chairperson of the Board. 
  
 3.      Each Director may request the convocation of a meeting of the Board of Directors by submitting a written agenda to the person
authorized to convene such meetings. 
  
 4.      Each Corporate Auditor may, when determined as necessary, pursuant to the provision of Article 12, Paragraph 3, request the convocation of a meeting of the Board of Directors to the person authorised to
convene such meetings. 
  
 5.      In the case a
request for a meeting referred to in the immediately preceding Paragraphs 3 and 4 is made, and if a notice of convocation of the meeting, which is set within two (2) weeks of the date of the request, is not issued within five (5) days of such
request for a meeting, the Director or Corporate Auditor who made the request may convene a meeting of the Board of Directors. 

	Article 8.	(Notice of Convocation) 

  
 Notice of convocation of a meeting of the Board of Directors shall specify the date, time and place and major agenda of such meeting and shall be
dispatched to each Director and each Corporate Auditor no later than three (3) days prior to the date of such meeting; provided, however, that in case of urgency, this period may be shortened. 
  

	Article 9.	(Omission of Convocation Procedure) 

  
 The convocation procedure for a meeting of the Board of Directors may be omitted with the unanimous consent of all Directors and Corporate Auditors.

  

	Article 10.	(Method of Adopting Resolutions) 

  
 1.      Resolutions of the Board of Directors shall be adopted by a majority of the Directors present at a meeting at which a majority of
the Directors then in office are present. 
  
 2.      Any Director who has a special interest in an agendum submitted to a meeting of the Board of Directors may not take part in the resolution as provided for in the immediately preceding paragraph. In such
case, the voting right of such Director shall not be counted in the number of the voting rights of the Directors present. 
  

	Article 11.	(Matters to Be Resolved) 

  
 Matters to be resolved at a meeting of the Board of Directors shall be matters specified in the appendix. 
  

	Article 12.	(Matters to Be Reported) 

  
 1.      Directors shall report the status of the operation of business to the Board of Directors once or more in every three (3) months.

  
 2.      A Director who has engaged in a
transaction as specified in (15) and (16) of the appendix as designated in the immediately preceding article shall disclose the material facts regarding such transaction and report thereof to the Board of Directors without delay. 
  
 3.      Each of the Corporate Auditors shall report to the
Board of Directors when a Director acts or may act beyond the Company’s purpose or in violation of laws and ordinances or the Articles of Incorporation. 
  

	Article 13.	(Urgent Measures) 

  
 If the President and Director determines that a matter that is specified in the immediately preceding Article 11 may not be discussed at a meeting of the
Board of Directors due to urgency, the President and Director may effect such matter without having approval of the Board of Directors; provided, however, that such matter shall be reported and approved thereafter at the next meeting of the Board of
Directors. 
  

	Article 14.	(Minutes) 

  
 1.      The summary of proceedings at a meeting of the Board of Directors and the results thereof shall be recorded in the minutes of the meeting, to which the Directors and Corporate
Auditors present shall put their names and affix their seals. 
  
 2.      Directors and Corporate Auditors who were not present at the meeting of the Board of Directors shall confirm the details of the proceedings through the minutes and other documents. 
  
 3.      Minutes shall be kept at the head office of the Company
for ten (10) years. 
  

	Article 15.	(Amendment to or Abolition of the Regulations) 

  
 Any amendment to or abolition of these Regulations shall be subject to a resolution of the Board of Directors. 
  

 - 2 - 

 ADDENDUM 
  

	Article 1.	(Date of Enforcement) 

  
 These Regulations, as amended, shall come into force on June 29, 1994 
 Partially amended on January 27, 1995 
 Partially amended on June 26, 1998 
 Partially amended on May 14, 2002 
  

 - 3 - 

 Appendix 
  

	1.	Matters stipulated by laws and ordinances: 

  

	 	(1)	Convocation of general meetings of shareholders and determination of agenda thereat; 

	 	(2)	Determination of Representative Directors and Directors with titles; 

	 	(3)	Appointment of candidates for Directors, Corporate Auditors and accounting auditors in addition to election and dismissal of managers and important employees;

	 	(4)	Issuance of new shares; 

	 	(5)	Issuance of stock acquisition rights; 

	 	(6)	Stock split and increase in number of authorized shares arising from the stock split in accordance of the split ratio; 

	 	(7)	Decrease in number of shares constituting one (1) unit of shares; 

	 	(8)	Abolition of unit share system; 

	 	(9)	Public offering of bonds; 

	 	(10)	Issuance of bonds with stock acquisition rights; 

	 	(11)	Capitalization of reserves; 

	 	(12)	Interim dividends (cash distributions pursuant to Article 293-5 of the Commercial Code); 

	 	(13)	Acquisition as well as cancellation and disposal of the Company’s own shares; 

	 	(14)	Acquisition of the Company’s own shares from its subsidiary; 

	 	(15)	Approval of transactions between Directors and the Company; 

	 	(16)	Approval of transactions by the Directors falling under the category of business of the Company; 

	 	(17)	Establishment, alteration and closure of branches and other material organizations; 

	 	(18)	Approval of balance sheets, profit and loss statements, business reports and schedules thereto, as well as determination of agenda and schedules thereto regarding the disposal of
profits or the treatment of losses; 

	 	(19)	Acquisition and transfer of material assets, as well as management and safe-guarding thereof; and 

	 	(20)	Loans in large amounts. 

  

	2.	Matters stipulated by the Articles of Incorporation: 

  

	 	(1)	Setting of the record date and making a public notice thereof (at the end of fiscal year and mid-term, as well as at any time in extraordinary case); 

	 	(2)	Appointment and change of the transfer agent; 

	 	(3)	Amendment to and abolition of the Share Handling Regulations; 

	 	(4)	Amendment to and abolition of the Regulations of the Board of Directors; and 

	 	(5)	Commission and removal of corporate adviser and consultant. 

  

	3.	Matters concerning the management of the business: 

  

	 	(1)	Determination of fundamental purposes of the Company and basic policies of the business of the Company; 

	 	(2)	Approval of assuming office of a director, corporate auditor and others of other companies; 

	 	(3)	Commission and removal of senior counselor; 

	 	(4)	Material lawsuits; 

	 	(5)	Execution of, amendment to and cancellation of material agreements; 

	 	(6)	Matters delegated by general meetings of shareholders; and 

	 	(7)	Other material matters in relation to the execution of business. 

  

 - 4 -Articles of Incorporation of Sankyo

 Exhibit 4.4 

 [English Translation] 
  
 ARTICLES OF INCORPORATION 
  
 OF 
  
 SANKYO COMPANY, LIMITED 
  
 Chapter 1      General Rules 
  
 Article 1 (Corporate Name) 
 The corporate name of the Company shall be Sankyo Kabushiki Kaisha and in English SANKYO
COMPANY, LIMITED. 
  
 Article 2 (Purpose) 
 The business purposes of the Company are as follows: 
  

	 	1.	Manufacture and sale of drugs, quasi-drugs, medical devices (including equipments and instruments, medical supplies, dental materials and sanitary materials), veterinary drugs,
cosmetics, agrochemicals, industrial chemicals and the other drugs, chemical foods, food additives, yeasts for bread, seasonings, livestock foods and livestock food additives. 

	 	2.	Sale of glass thermometer and industrial alcohol 

	 	3.	Export, import and sale of items stipulated in the clause 2.1.1 and 2.2.2, and items relating to them and the other machines and equipments. 

	 	4.	Manufacture and wholesale of alcohol and drinking water. 

	 	5.	Business incidental to the foregoing. 

  
 Article 3 (Location of Principal Office) 
 The principal office of the
Company shall be located in Chuo-ku, Tokyo. 
  
 Article 4 (Method of Public
Notice) 
 Public notice of the Company shall be inserted in The Nihon Keizai Shinbun. 
  
 Chapter 2      Shares 
  
 Article 5 (Total Number of Shares, Purchase of Treasury Stock, Number of Shares constituting One Unit and Non Issuance of Share
Certificates for Shares less than One Unit) 
  
 5.1      The total number of shares authorized to be issued by the Company shall be one billion and one hundred sixty-eight million ninety-nine thousand (1,168,099,000). If shares are retired, the number of
such shares shall be decreased. 
 5.2      The Company may purchase treasury stock by a resolution of the Board of Directors as
provided for under Item 2, Paragraph 1, Article 211-3 of the Commercial Code. 
 5.3      The number of shares constituting one
unit shall be one hundred (100). 
 5.4      The Company does not issue share certificates for any shares less than one unit
(“Shares Less Than One Unit”). If Share Handling Regulation provides otherwise, this clause shall not be applied. 

 [English Translation] 
  
 Article 6 (Transfer Agent) 
 6.1      The Company shall have a transfer agent for its shares. 
 6.2      The transfer
agent and its business place shall be determined by the resolution of the Board of Directors, and shall be placed for the public notice. 
 6.3      The register of shareholders and the register of real shareholders of the Company (collectively, “Register of Shareholders, etc.”) shall be kept at the business place of the transfer agent,
and the Company shall have the transfer agent do, and the Company shall not do, all business relating to shares such as entering a change of shareholders in the Register of Shareholders, etc. and purchasing Shares Less Than One Unit. 
  
 Article 7 (Share Handling Regulation) 
 Matters relating to shares such as entry of a change of shareholders in the Register of Shareholders, etc. and purchase of Shares Less Than One Unit shall be governed by
the Share Handling Regulation established by the resolution of the Board of Directors. 
  
 Article 8 (Record Date) 
 8.1      The Company shall deem the shareholders (hereinafter including real
shareholders) who have voting rights and who are registered or recorded on the final Register of Shareholders, etc., as of March 31 ever year to be the shareholders eligible to exercise voting rights at the Ordinary General Meeting of Shareholders
for the period for the settlement of accounts. 
 8.2      The Company may set a record date by the resolution of the Board of
Directors if necessary for determination of the shareholders eligible to Interim Dividends provided by the Article 31 of these Articles of Incorporation or for other reasons. 
  
 Chapter 3      General Meeting of Shareholders 
  
 Article 9 (Convocation) 
 The Ordinary General Meeting of Shareholders shall be convened in June every year, and an Extraordinary General Meeting of Shareholders shall be convened at any time as necessary. 
  
 Article 10 (Chairman) 
 A Representative Director and President shall act as chairman of the General Meeting of Shareholders. If the Representative Director and President is unable to so act, one of the other Directors shall act as chairman
in precedence as previously determined by the Board of Directors. 
  
 Article
11 (Exercise of Voting Rights by Proxy) 
 11.1      Shareholders or their legal representative may appoint another
shareholder having voting rights as their proxy and exercise their voting rights through the proxy. 
 11.2      In the event of
the clause 11.1, the shareholders or the proxy must submit to the Company a document establishing power of representation. 
  
 Article 12 (Method of Resolution) 
 Resolutions at the General Meeting
of Shareholders shall be made by a majority of voting rights of shareholders present, unless otherwise provided by laws and ordinances or by these Articles of Incorporation. 
  
 Article 13 (Minutes) 
 The proceedings of
the General Meeting of Shareholders shall be recorded in the minutes with name written and seal affixed by Chairman and Directors present, and the minutes shall be kept at the Company. 

 [English Translation] 
  
 Chapter 4      Director and Board of Directors 
  
 Article 14 (Number) 
 The number of Directors shall be three (3) or more. 
  
 Article 15 (Election) 
 15.1      Directors shall be elected at the General Meeting of Shareholders.

 15.2      For the resolution of the election of Directors, the presence of shareholders representing at least one-third (1/3)
of voting rights of all shareholders is required. 
 15.3      No cumulative voting shall be used for the resolution of the
election of Directors. 
  
 Article 16 (Term of Office) 
 The term of office of each Director shall expire at the close of the Ordinary General Meeting of Shareholders held for the period for settlement of accounts within one
(1) year after his/her assumption of office. 
  
 Article 17 (Convocation)

 A notice to convene the Board of Directors shall be sent to each Director and Corporate Auditor at least three (3) days before the meeting date. If all
Directors and Corporate Auditors agree to convene the Board of Directors, this Article shall not be applied. 
  
 Article 18 (Method of Resolution) 
 The resolution of the Board of Directors shall be made by majority of votes of
Directors present who constitute majority in number of all Directors. 
  
 Article 19 (Authority of Board of Directors) 
 The Board of Directors shall decide important matters relating to administration of affairs of
the Company as well as matters provided by laws and ordinances or by these Articles of Incorporation. 
  
 Article 20 (Executive Director and Representative Director) 
 20.1      The Board of
Directors may designate Chairman, President, Executive Vice-president, Executive Managing Director and Managing Director. 
 20.2      The Board of Directors shall decide the Director representing the Company. 
  
 Article 21 (Regulation of the Board of Directors) 
 Matters except for
provided by this Chapter shall be governed by the Regulation of the Board of Directors established by the resolution of the Board of Directors. 
  
 Chapter 5      Corporate Auditor and Board of Corporate Auditors 
  
 Article 22 (Number) 
 The number of Corporate Auditors shall be three (3) or more. 
  
 Article 23 (Election) 
 23.1      Corporate Auditors shall be elected at the General
Meeting of Shareholders. 
 23.2      For the resolution of the election of Corporate Auditors, the presence of shareholders
representing at least one-third (1/3) of voting rights of all shareholders is required. 

 [English Translation] 
  
 Article 24 (Term of Office) 
 24.1      The term of office of each Corporate Auditor shall expire at the close of the Ordinary General Meeting of Shareholders held for the last period for settlement of accounts within four (4) year after
his/her assumption of office. 
 24.2      The term of office of a Corporate Auditor who was appointed for filling the vacancy
of the Corporate Auditor having retired from office before expiration of his/her office shall expire at the time of expiration of the term of office of the retired Corporate Auditor. 
  
 Article 25 (Convocation) 
 A notice to
convene the Board of Corporate Auditors shall be sent to each Corporate Auditor at least three (3) days before the meeting date. If all Corporate Auditors agree to convene the Board of Corporate Auditors, this Article shall not be applied.

  
 Article 26 (Method of Resolution) 
 The resolution of the Board of Corporate Auditors shall be made by majority of votes of Corporate Auditors unless otherwise provided by laws and ordinances. 

 
 Article 27 (Full-time Corporate Auditor) 
 Corporate Auditors shall by mutual agreement designate Full-time Corporate Auditors from among themselves. 
  
 Article 28 (Regulation of Board of Corporate Auditors) 
 Matters excepted for provided by this Chapter shall be governed by the Regulation of Board of Corporate Auditors established by the resolution of the Board of Corporate Auditors. 
  
 Chapter 6      Accounts 
  
 Article 29 (Fiscal Year and Settlement of Accounts) 
 29.1      The fiscal year of the Company shall commence on April 1 every year and end on March 31 of the following year. 
 29.2      Settlement of accounts shall be performed at the last day of each fiscal year. 
  
 Article 30 (Dividend) 
 The dividend shall be paid to shareholders or registered pledgees registered or recorded in the final Register of Shareholders, etc., as of the last day of each fiscal year. 
  
 Article 31 (Interim Dividend) 
 The Company may make money distribution (“Interim Dividend”) provided by Article 293-5 of the Commercial Code by the resolution of the Board of Directors to the
shareholders and registered pledgees registered or recorded in the final Register of Shareholders, etc., as of September 30 every year. 
  
 Article 32 (Annulment Term) 
 The Company is exempted from liability
for paying dividend and Interim Dividend if the same remains unclaimed after three (3) years have elapsed from the first date on which such dividend and Interim Dividend became payable.

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