Document:

exv4w3

 

Exhibit 4.3

OMEROS CORPORATION

AMENDED AND RESTATED

INVESTORS’ RIGHTS AGREEMENT

October 15, 2004

 

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Page	 
	 
	 	 	 	 	 	 	 	 
	1.
	 	Registration Rights	 	 	2	 
	 
	 	1.1	 	Definitions	 	 	2	 
	 
	 	1.2	 	Request for Registration	 	 	3	 
	 
	 	1.3	 	Company Registration	 	 	4	 
	 
	 	1.4	 	Form S-3 Registration	 	 	4	 
	 
	 	1.5	 	Obligations of the Company	 	 	5	 
	 
	 	1.6	 	Furnish Information	 	 	7	 
	 
	 	1.7	 	Expenses of Registration	 	 	7	 
	 
	 	1.8	 	Underwriting Requirements	 	 	8	 
	 
	 	1.9	 	Delay of Registration	 	 	9	 
	 
	 	1.10	 	Indemnification	 	 	9	 
	 
	 	1.11	 	Reports Under Securities Exchange Act of 1934	 	 	11	 
	 
	 	1.12	 	Assignment of Registration Rights	 	 	11	 
	 
	 	1.13	 	Limitations on Subsequent Registration Rights	 	 	12	 
	 
	 	1.14	 	Market Stand-Off Agreement	 	 	12	 
	 
	 	1.15	 	Termination of Registration Rights	 	 	13	 
	2.
	 	Covenants of the Company	 	 	13	 
	 
	 	2.1	 	Delivery of Financial Statements	 	 	13	 
	 
	 	2.2	 	Inspection	 	 	13	 
	 
	 	2.3	 	Right of First Offer	 	 	14	 
	 
	 	2.4	 	Termination of Covenants	 	 	15	 
	3.
	 	Restrictions on Transfer	 	 	16	 
	 
	 	3.1	 	Notice of Sales; Right of First Refusal	 	 	16	 
	 
	 	3.2	 	Failure to Exercise	 	 	17	 
	 
	 	3.3	 	No Transfers without Board Approval	 	 	17	 
	 
	 	3.4	 	Permitted Transactions	 	 	17	 
	 
	 	3.5	 	Prohibited Transfers	 	 	18	 
	 
	 	3.6	 	Legended Certificates	 	 	18	 
	 
	 	3.7	 	Termination	 	 	18	 
	4.
	 	Miscellaneous	 	 	19	 
	 
	 	4.1	 	Successors and Assigns	 	 	19	 
	 
	 	4.2	 	Amendments and Waivers	 	 	19	 
	 
	 	4.3	 	Notices	 	 	19	 
	 
	 	4.4	 	Severability	 	 	19	 
	 
	 	4.5	 	Governing Law	 	 	20	 
	 
	 	4.6	 	Counterparts	 	 	20	 
	 
	 	4.7	 	Titles and Subtitles	 	 	20	 
	 
	 	4.8	 	Aggregation of Stock	 	 	20	 
	 
	 	4.9	 	Entire Agreement	 	 	20	 
	 
	 	4.10	 	Telecopy Execution and Delivery	 	 	20	 
	 
	 	4.11	 	Arbitration	 	 	20	 
	 
	 	4.12	 	Termination and Supersession	 	 	21	 

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OMEROS CORPORATION

AMENDED AND RESTATED

INVESTORS’ RIGHTS AGREEMENT

     This Amended and Restated Investors’ Rights Agreement (this “Agreement”) is made as of
the 15th day of October, 2004 by and among Omeros Corporation, a Washington corporation
(the “Company”), the investors listed on Exhibit A hereto (the “Series E
Investors”), H. Raymond Cairncross, Gregory A. Demopulos, M.D., George Kargianis, and Pamela
Pierce Palmer, M.D., Ph.D., each of whom is herein referred to as a “Founder,” the holders
of Series A Preferred Stock of the Company (the “Series A Preferred Stock”) listed on
Exhibit B hereto (the “Series A Investors”), the holders of Series B Preferred
Stock of the Company (the “Series B Preferred Stock”) listed on Exhibit C hereto
(the “Series B Investors”), the holders of Series C Preferred Stock of the Company (the
“Series C Preferred Stock”) listed on Exhibit D hereto (the “Series C
Investors”), the holders of the Series D Preferred Stock of the Company (the “Series D
Preferred Stock”) listed on Exhibit E hereto (the “Series D Investors,” and
together with the Series A Investors, the Series B Investors, the Series C Investors and the Series
E Investors, the “Investors”), and the holders of Common Stock of the Company (the
“Common Stock”) listed on Exhibit F hereto (the “Common Shareholders”).

RECITALS

     The Company, the Founders, the Common Shareholders and the Investors are parties to the
Amended and Restated Investors’ Rights Agreement dated as of March 16, 2004, as amended on March
19, 2004 (the “Prior Agreement”). The Company issued and sold to the Series E Investors
shares of its Series E Preferred Stock pursuant to the Series E Preferred Stock Purchase Agreement
(the “Purchase Agreement”) dated March 16, 2004 and Addendum Agreements thereto. A
condition to the Series E Investors’ obligations under the Purchase Agreement and the Addendum
Agreements thereto was that the Company, the Founders, the Common Shareholders and the Investors
enter into the Prior Agreement in order to provide the Investors with (i) certain rights to
register shares of Common Stock issuable upon conversion of the Preferred Stock held by the
Investors, (ii) certain rights to receive or inspect information pertaining to the Company, (iii) a
right of first offer with respect to certain issuances by the Company of its securities and (iv) a
right of first refusal upon proposed sales of the Company’s securities held by the Investors and
the Common Shareholders. The Company, the Investors, the Founders and the Common Shareholders each
desire to amend and restate the Prior Agreement in its entirety as set forth herein in order to,
among other things, provide certain of such rights to additional Investors.

 

 

AGREEMENT

     The parties hereby agree as follows:

     1. Registration Rights. The Company and the Investors covenant and agree as follows:

          1.1 Definitions. For purposes of this Section 1:

               (a) The terms “register,” “registered,” and “registration” refer to a
registration effected by preparing and filing a registration statement or similar document in
compliance with the Securities Act of 1933, as amended (the “Securities Act”), and the
declaration or ordering of effectiveness of such registration statement or document;

               (b) The term “Registrable Securities” means (i) the shares of Common Stock issuable or
issued upon conversion of the Series A, Series B, Series C, Series D and Series E Preferred Stock,
(ii) the shares of Common Stock issued to the Founders (the “Founders’ Stock”),
provided, however, that for the purposes of Section 1.2, 1.4 and 1.13 the Founders’
Stock shall not be deemed Registrable Securities and the Founders shall not be deemed Holders, and
(iii) any other shares of Common Stock of the Company issued as (or issuable upon the conversion or
exercise of any warrant, right or other security which is issued as) a dividend or other
distribution with respect to, or in exchange for or in replacement of, the shares listed in (i) and
(ii); provided, however, that the foregoing definition shall exclude in all cases
any Registrable Securities sold by a person in a transaction in which his or her rights under this
Agreement are not assigned. Notwithstanding the foregoing, Common Stock or other securities shall
only be treated as Registrable Securities if and so long as they have not been (A) sold to or
through a broker or dealer or underwriter in a public distribution or a public securities
transaction, or (B) sold in a transaction exempt from the registration and prospectus delivery
requirements of the Securities Act under Section 4(1) thereof so that all transfer restrictions,
and restrictive legends with respect thereto, if any, are removed upon the consummation of such
sale;

               (c) The number of shares of “Registrable Securities then outstanding” shall be
determined by the number of shares of Common Stock outstanding which are, and the number of shares
of Common Stock issuable pursuant to then exercisable or convertible securities which are,
Registrable Securities;

               (d) The term “Holder” means any person owning or having the right to acquire
Registrable Securities or any assignee thereof in accordance with Section 1.12 of this Agreement;

               (e) The term “Form S-3” means such form under the Securities Act as in effect on the
date hereof or any successor form under the Securities Act;

               (f) The term “SEC” means the Securities and Exchange Commission; and

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               (g) The term “Qualified IPO” means a firm commitment underwritten public offering by
the Company of shares of its Common Stock pursuant to a registration statement under the Securities
Act, which results in aggregate gross proceeds to the Company of at least $10,000,000.

          1.2 Request for Registration.

               (a) If the Company shall receive at any time after the earlier of (i) three (3) years after
the Closing (as defined in the Purchase Agreement) or (ii) six (6) months after the effective date
of the first registration statement for a public offering of securities of the Company (other than
a registration statement relating either to the sale of securities to employees of the Company
pursuant to a stock option, stock purchase or similar plan or an SEC Rule 145 transaction), a
written request from the Holders of at least thirty percent (30%) of the Registrable Securities
then outstanding that the Company file a registration statement under the Securities Act covering
the registration of Registrable Securities with an anticipated aggregate gross offering price in
excess of $10,000,000, then the Company shall, within ten (10) days of the receipt thereof, give
written notice of such request to all Holders and shall, subject to the limitations of subsection
1.2(b), use its best efforts to effect as soon as practicable, and in any event within 60 days of
the receipt of such request, the registration under the Securities Act of all Registrable
Securities which the Holders request to be registered within twenty (20) days of the mailing of
such notice by the Company in accordance with Section 4.3.

               (b) If the Holders initiating the registration request hereunder (“Initiating
Holders”) intend to distribute the Registrable Securities covered by their request by means of
an underwriting, they shall so advise the Company as a part of their request made pursuant to this
Section 1.2 and the Company shall include such information in the written notice referred to in
subsection 1.2(a). The underwriter will be selected by a majority in interest of the Initiating
Holders and shall be reasonably acceptable to the Company. In such event, the right of any Holder
to include his Registrable Securities in such registration shall be conditioned upon such Holder’s
participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the
underwriting (unless otherwise mutually agreed by a majority in interest of the Initiating Holders
and such Holder) to the extent provided herein. All Holders proposing to distribute their
securities through such underwriting shall (together with the Company as provided in subsection
1.5(e)) enter into an underwriting agreement in customary form with the underwriter or underwriters
selected for such underwriting. Notwithstanding any other provision of this Section 1.2, if the
underwriter advises the Initiating Holders in writing that marketing factors require a limitation
of the number of shares to be underwritten, then the Initiating Holders shall so advise all Holders
of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of
shares of Registrable Securities that may be included in the underwriting shall be allocated among
all Holders thereof, including the Initiating Holders, in proportion (as nearly as practicable) to
the amount of Registrable Securities of the Company owned by each Holder; provided,
however, that the number of shares of Registrable Securities to be included in such
underwriting shall not be reduced unless all other securities are first entirely excluded from the
underwriting.

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               (c) Notwithstanding the foregoing, if the Company shall furnish to Holders requesting a
registration statement pursuant to this Section 1.2 a certificate signed by the President of the
Company stating that in the good faith judgment of the Board of Directors of the Company, it would
be seriously detrimental to the Company and its shareholders for such registration statement to be
filed and it is therefore essential to defer the filing of such registration statement, the Company
shall have the right to defer such filing for a period of not more than 120 days after receipt of
the request of the Initiating Holders; provided, however, that the Company may not
utilize this right more than once in any twelve-month period.

               (d) In addition, the Company shall not be obligated to effect, or to take any action to
effect, any registration pursuant to this Section 1.2:

                    (i) After the Company has effected one (1) registration pursuant to this Section 1.2 and such
registration has been declared or ordered effective;

                    (ii) During the period starting with the date sixty (60) days prior to the Company’s good
faith estimate of the date of filing of, and ending on a date one hundred eighty (180) days after
the effective date of, a registration subject to Section 1.3 hereof; provided that the
Company is actively employing in good faith all reasonable efforts to cause such registration
statement to become effective; or

                    (iii) If the Initiating Holders propose to dispose of shares of Registrable Securities that
may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 1.4 below.

          1.3 Company Registration. If (but without any obligation to do so) the Company
proposes to register (including for this purpose a registration effected by the Company for
shareholders other than the Holders) any of its stock under the Securities Act in connection with
the public offering of such securities solely for cash (other than a registration relating solely
to the sale of securities to participants in a Company stock plan or a transaction covered by Rule
145 under the Securities Act, a registration in which the only stock being registered is Common
Stock issuable upon conversion of debt securities which are also being registered, or any
registration on any form which does not include substantially the same information as would be
required to be included in a registration statement covering the sale of the Registrable
Securities), the Company shall, at such time, promptly give each Holder written notice of such
registration. Upon the written request of each Holder given within twenty (20) days after mailing
of such notice by the Company in accordance with Section 4.3, the Company shall, subject to the
provisions of Section 1.8, cause to be registered under the Securities Act all of the Registrable
Securities that each such Holder has requested to be registered.

          1.4 Form S-3 Registration. In case the Company shall receive from any Holder or
Holders of not less than twenty percent (20%) of the Registrable Securities then outstanding a
written request or requests that the Company effect a registration on Form S-3 and
any related qualification or compliance with respect to all or a part of the Registrable
Securities owned by such Holder or Holders, the Company will:

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               (a) promptly give written notice of the proposed registration, and any related qualification
or compliance, to all other Holders; and

               (b) as soon as practicable, effect such registration and all such qualifications and
compliances as may be so requested and as would permit or facilitate the sale and distribution of
all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such
request, together with all or such portion of the Registrable Securities of any other Holder or
Holders joining in such request as are specified in a written request given within 15 days after
receipt of such written notice from the Company; provided, however, that the
Company shall not be obligated to effect any such registration, qualification or compliance,
pursuant to this Section 1.4: (i) if Form S-3 is not available for such offering by the Holders;
(ii) if the Holders, together with the holders of any other securities of the Company entitled to
inclusion in such registration, propose to sell Registrable Securities and such other securities
(if any) at an aggregate price to the public (net of any underwriters’ discounts or commissions) of
less than $2,500,000; (iii) if the Company shall furnish to the Holders a certificate signed by the
President of the Company stating that in the good faith judgment of the Board of Directors of the
Company, it would be seriously detrimental to the Company and its shareholders for such Form S-3
Registration to be effected at such time, in which event the Company shall have the right to defer
the filing of the Form S-3 registration statement for a period of not more than 120 days after
receipt of the request of the Holder or Holders under this Section 1.4; provided,
however, that the Company shall not utilize this right more than once in any twelve month
period; (iv) if the Company has, within the twelve (12) month period preceding the date of such
request, already effected one (1) registration on Form S-3 for the Holders pursuant to this Section
1.4; (v) in any particular jurisdiction in which the Company would be required to qualify to do
business or to execute a general consent to service of process in effecting such registration,
qualification or compliance; or (vi) during the period ending one hundred eighty (180) days after
the effective date of a registration statement subject to Section 1.3.

               (c) Subject to the foregoing, the Company shall file a registration statement covering the
Registrable Securities and other securities so requested to be registered as soon as practicable
after receipt of the request or requests of the Holders. Registrations effected pursuant to this
Section 1.4 shall not be counted as demands for registration or registrations effected pursuant to
Sections 1.2 or 1.3, respectively.

          1.5 Obligations of the Company. Whenever required under this Section 1 to effect the
registration of any Registrable Securities, the Company shall, as expeditiously as reasonably
possible:

               (a) Prepare and file with the SEC a registration statement with respect to such Registrable
Securities and use its best efforts to cause such registration statement to become effective, and,
upon the request of the Holders of a majority of the Registrable Securities registered thereunder,
keep such registration statement effective for up to one hundred twenty (120) days. The Company shall not be required to file, cause to become effective or maintain
the effectiveness of any registration statement that contemplates a distribution of securities on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act.

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               (b) Prepare and file with the SEC such amendments and supplements to such registration
statement and the prospectus used in connection with such registration statement as may be
necessary to comply with the provisions of the Securities Act with respect to the disposition of
all securities covered by such registration statement for up to one hundred twenty (120) days.

               (c) Furnish to the Holders such numbers of copies of a prospectus, including a preliminary
prospectus, in conformity with the requirements of the Securities Act, and such other documents as
they may reasonably request in order to facilitate the disposition of Registrable Securities owned
by them.

               (d) Use its best efforts to register and qualify the securities covered by such registration
statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably
requested by the Holders; provided that the Company shall not be required in connection
therewith or as a condition thereto to qualify to do business or to file a general consent to
service of process in any such states or jurisdictions.

               (e) In the event of any underwritten public offering, enter into and perform its obligations
under an underwriting agreement, in usual and customary form, with the managing underwriter of such
offering. Each Holder participating in such underwriting shall also enter into and perform its
obligations under such an agreement.

               (f) Notify each Holder of Registrable Securities covered by such registration statement at any
time when a prospectus relating thereto is required to be delivered under the Securities Act of the
happening of any event as a result of which the prospectus included in such registration statement,
as then in effect, includes an untrue statement of a material fact or omits to state a material
fact required to be stated therein or necessary to make the statements therein not misleading in
the light of the circumstances, such obligation to continue for so long as the Company is obligated
to maintain the effectiveness of such registration statement.

               (g) Cause all such Registrable Securities registered pursuant hereunder to be listed on each
securities exchange on which similar securities issued by the Company are then listed.

               (h) Provide a transfer agent and registrar for all Registrable Securities registered pursuant
hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the
effective date of such registration.

               (i) Use its best efforts to furnish, at the request of any Holder requesting registration of
Registrable Securities pursuant to this Section 1, on the date that such Registrable Securities are
delivered to the underwriters for sale in connection with a registration
pursuant to this Section 1, if such securities are being sold through underwriters, or, if
such securities are not being sold through underwriters, on the date that the registration
statement with respect to such securities becomes effective, (i) an opinion, dated such date, of
the counsel representing the Company for the purposes of such registration, in form and substance
as is customarily given to underwriters in an underwritten public offering, addressed to the

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underwriters, if any, and to the Holders requesting registration of Registrable Securities and (ii)
a letter dated such date, from the independent certified public accountants of the Company, in form
and substance as is customarily given by independent certified public accountants to underwriters
in an underwritten public offering, addressed to the underwriters, if any, and to the Holders
requesting registration of Registrable Securities.

          1.6 Furnish Information. It shall be a condition precedent to the obligations of the
Company to take any action pursuant to this Section 1 with respect to the Registrable Securities of
any selling Holder that such Holder shall furnish to the Company such information regarding itself,
the Registrable Securities held by it, and the intended method of disposition of such securities as
shall be required to effect the registration of such Holder’s Registrable Securities. The Company
shall have no obligation with respect to any registration requested pursuant to Section 1.2 or
Section 1.4 of this Agreement if, as a result of the application of the preceding sentence, the
number of shares or the anticipated aggregate offering price of the Registrable Securities to be
included in the registration does not equal or exceed the number of shares or the anticipated
aggregate offering price required to originally trigger the Company’s obligation to initiate such
registration as specified in subsection 1.2(a) or subsection 1.4(b)(ii), whichever is applicable.

          1.7 Expenses of Registration.

               (a) Demand Registration. All expenses other than underwriting discounts and
commissions incurred in connection with registrations, filings or qualifications pursuant to
Section 1.2, including (without limitation) all registration, filing and qualification fees,
printers’ and accounting fees, fees and disbursements of counsel for the Company, and the
reasonable fees and disbursements of one counsel for the selling Holders selected by them with the
approval of the Company, which approval shall not be unreasonably withheld, shall be borne by the
Company; provided, however, that the Company shall not be required to pay for any
expenses of any registration proceeding begun pursuant to Section 1.2 if the registration request
is subsequently withdrawn at the request of the Holders of a majority of the Registrable Securities
to be registered (in which case all participating Holders shall bear such expenses), unless the
Holders of a majority of the Registrable Securities agree to forfeit their right to one demand
registration pursuant to Section 1.2; provided, however, that if at the time of
such withdrawal, the Holders have learned of a material adverse change in the condition, business,
or prospects of the Company from that known to the Holders at the time of their request and have
withdrawn the request with reasonable promptness following disclosure by the Company of such
material adverse change, then the Holders shall not be required to pay any of such expenses and
shall retain their rights pursuant to Section 1.2.

               (b) Company Registration. All expenses other than underwriting discounts and
commissions incurred in connection with registrations, filings or qualifications of Registrable
Securities pursuant to Section 1.3 for each Holder (which right may be assigned as provided in
Section 1.12), including (without limitation) all registration, filing, and qualification fees,
printers’ and accounting fees, fees and disbursements of counsel for the Company and the reasonable
fees and disbursements of one counsel for the selling Holder or Holders selected by

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them with the approval of the Company, which approval shall not be unreasonably withheld, shall be borne by the
Company.

               (c) Registration on Form S-3. All expenses incurred in connection with a registration
requested pursuant to Section 1.4, including (without limitation) all registration, filing,
qualification, printers’ and accounting fees and the reasonable fees and disbursements of one
counsel for the selling Holder or Holders selected by them with the approval of the Company, which
approval shall not be unreasonably withheld, and counsel for the Company, but not including any
underwriters’ discounts or commissions associated with Registrable Securities, shall be borne by
the Company.

          1.8 Underwriting Requirements. In connection with any offering involving an
underwriting of shares of the Company’s capital stock, the Company shall not be required under
Section 1.3 to include any of the Holders’ securities in such underwriting unless they accept the
terms of the underwriting as agreed upon between the Company and the underwriters selected by it
(or by other persons entitled to select the underwriters), and then only in such quantity as the
underwriters determine in their sole discretion will not jeopardize the success of the offering by
the Company. If the total amount of securities, including Registrable Securities, requested by
shareholders to be included in such offering exceeds the amount of securities sold other than by
the Company that the underwriters determine in their sole discretion is compatible with the success
of the offering, then the Company shall be required to include in the offering only that number of
such securities, including Registrable Securities, which the underwriters determine in their sole
discretion will not jeopardize the success of the offering (the securities so included to be
apportioned pro rata among the selling shareholders according to the total amount of securities
entitled to be included therein owned by each selling shareholder or in such other proportions as
shall mutually be agreed to by such selling shareholders), but in no event shall (i) any shares
being sold by a shareholder exercising a demand registration right similar to that granted in
Section 1.2 be excluded from such offering, (ii) the amount of securities of the selling Holders of
Preferred Stock included in the offering be reduced below thirty percent (30%) of the total amount
of securities included in such offering, unless such offering is the initial public offering of the
Company’s securities, in which case (except as provided in (i) above) the selling shareholders may
be excluded entirely if the underwriters make the determination described above and no other
shareholder’s securities are included or (iii) any securities held by a Founder be included if any
securities held by any selling Holder are excluded. For purposes of the preceding parenthetical
concerning apportionment, for any selling shareholder which is a holder of Registrable Securities
and which is a partnership or corporation, the partners, retired partners and shareholders of such
holder, or the estates and family members of any such partners and retired partners and any trusts
for the benefit of any of the foregoing persons shall be deemed to be a single “selling
shareholder,” and any pro-rata reduction with respect to such “selling shareholder” shall be based upon the aggregate amount of shares carrying registration rights
owned by all entities and individuals included in such “selling shareholder,” as defined in this
sentence.

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          1.9 Delay of Registration. No Holder shall have any right to obtain or seek an
injunction restraining or otherwise delaying any such registration as the result of any controversy
that might arise with respect to the interpretation or implementation of this Section 1.

          1.10 Indemnification. In the event any Registrable Securities are included in a
registration statement under this Section 1:

               (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder,
the partners, officers, directors and shareholders of each Holder, any underwriter (as defined in
the Securities Act) for such Holder and each person, if any, who controls such Holder or
underwriter within the meaning of the Securities Act or the Securities Exchange Act of 1934, as
amended (the “Exchange Act”), against any losses, claims, damages, or liabilities (joint or
several) to which they may become subject under the Securities Act, the Exchange Act or other
federal or state law, insofar as such losses, claims, damages, or liabilities (or actions in
respect thereof) arise out of or are based upon any of the following statements, omissions or
violations (collectively a “Violation”): (i) any untrue statement or alleged untrue
statement of a material fact contained in such registration statement, including any preliminary
prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the
omission or alleged omission to state therein a material fact required to be stated therein, or
necessary to make the statements therein not misleading, or (iii) any violation or alleged
violation by the Company of the Securities Act, the Exchange Act, any state securities law or any
rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities
law; and the Company will pay to each such Holder, underwriter or controlling person, as incurred,
any legal or other expenses reasonably incurred by them in connection with investigating or
defending any such loss, claim, damage, liability, or action; provided, however,
that the indemnity agreement contained in this subsection 1.10(a) shall not apply to amounts paid
in settlement of any such loss, claim, damage, liability, or action if such settlement is effected
without the consent of the Company (which consent shall not be unreasonably withheld), nor shall
the Company be liable to any Holder, underwriter, controlling person or other aforementioned person
for any such loss, claim, damage, liability, or action to the extent that it arises out of or is
based upon a Violation which occurs in reliance upon and in conformity with written information
furnished expressly for use in connection with such registration by any such Holder, underwriter,
controlling person or other aforementioned person.

               (b) To the extent permitted by law, each selling Holder will indemnify and hold harmless the
Company, each of its directors, each of its officers who has signed the registration statement,
each person, if any, who controls the Company within the meaning of the Securities Act, any
underwriter, any other Holder selling securities in such registration statement and any controlling
person of any such underwriter or other Holder, against any losses, claims, damages, or liabilities (joint or several) to which any of the foregoing persons may become
subject, under the Securities Act, the Exchange Act or other federal or state law, insofar as such
losses, claims, damages, or liabilities (or actions in respect thereto) arise out of or are based
upon any Violation, in each case to the extent (and only to the extent) that such Violation occurs
in reliance upon and in conformity with written information furnished by such Holder expressly for

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use in connection with such registration; and each such Holder will pay, as incurred, any legal or
other expenses reasonably incurred by any person intended to be indemnified pursuant to this
subsection 1.10(b), in connection with investigating or defending any such loss, claim, damage,
liability, or action; provided, however, that the indemnity agreement contained in
this subsection 1.10(b) shall not apply to amounts paid in settlement of any such loss, claim,
damage, liability or action if such settlement is effected without the consent of the Holder, which
consent shall not be unreasonably withheld; provided, that in no event shall any indemnity
under this subsection 1.10(b) exceed the net proceeds from the offering received by such Holder,
except in the case of willful fraud by such Holder.

               (c) Promptly after receipt by an indemnified party under this Section 1.10 of notice of the
commencement of any action (including any governmental action), such indemnified party will, if a
claim in respect thereof is to be made against any indemnifying party under this Section 1.10,
deliver to the indemnifying party a written notice of the commencement thereof and the indemnifying
party shall have the right to participate in, and, to the extent the indemnifying party so desires,
jointly with any other indemnifying party similarly noticed, to assume the defense thereof with
counsel mutually satisfactory to the parties; provided, however, that an
indemnified party (together with all other indemnified parties which may be represented without
conflict by one counsel) shall have the right to retain one separate counsel, with the reasonable
fees and expenses to be paid by the indemnifying party, if representation of such indemnified party
by the counsel retained by the indemnifying party would be inappropriate due to actual or potential
differing interests between such indemnified party and any other party represented by such counsel
in such proceeding. The failure to deliver written notice to the indemnifying party within a
reasonable time of the commencement of any such action, if prejudicial to its ability to defend
such action, shall relieve such indemnifying party of any liability to the indemnified party under
this Section 1.10, but the omission so to deliver written notice to the indemnifying party will not
relieve it of any liability that it may have to any indemnified party otherwise than under this
Section 1.10.

               (d) If the indemnification provided for in this Section 1.10 is held by a court of competent
jurisdiction to be unavailable to an indemnified party with respect to any loss, liability, claim,
damage or expense referred to therein, then the indemnifying party, in lieu of indemnifying such
indemnified party hereunder, shall contribute to the amount paid or payable by such indemnified
party as a result of such loss, liability, claim, damage, or expense in such proportion as is
appropriate to reflect the relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the statements or omissions that resulted in such
loss, liability, claim, damage or expense as well as any other relevant equitable considerations;
provided that in no event shall any contribution by a Holder under this subsection 1.10(d)
exceed the net proceeds from the offering received by such Holder, except in the case of willful
fraud by such Holder. The relative fault of the indemnifying party and of the indemnified party
shall be determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission to state a material fact relates to
information supplied by the indemnifying party or by the indemnified party and the parties’
relative intent, knowledge, access to information, and opportunity to correct or prevent such
statement or omission.

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               (e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and
contribution contained in the underwriting agreement entered into in connection with the
underwritten public offering are in conflict with the foregoing provisions, the provisions in the
underwriting agreement shall control.

               (f) The obligations of the Company and Holders under this Section 1.10 shall survive the
completion of any offering of Registrable Securities in a registration statement under this Section
1, and otherwise.

          1.11 Reports Under Securities Exchange Act of 1934. With a view to making available
to the Holders the benefits of Rule 144 promulgated under the Securities Act and any other rule or
regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the
public without registration or pursuant to a registration on Form S-3, the Company agrees to:

               (a) make and keep public information available, as those terms are understood and defined in
SEC Rule 144, at all times after ninety (90) days after the effective date of the first
registration statement filed by the Company for the offering of its securities to the general
public so long as the Company remains subject to the periodic reporting requirements under Sections
13 or 15(d) of the Exchange Act;

               (b) take such action, including the voluntary registration of its Common Stock under Section
12 of the Exchange Act, as is necessary to enable the Holders to utilize Form S-3 for the sale of
their Registrable Securities, such action to be taken as soon as practicable after the end of the
fiscal year in which the first registration statement filed by the Company for the offering of its
securities to the general public is declared effective;

               (c) file with the SEC in a timely manner all reports and other documents required of the
Company under the Securities Act and the Exchange Act; and

               (d) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith
upon request (i) a written statement by the Company that it has complied with the reporting
requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the
first registration statement filed by the Company), the Securities Act and the Exchange Act (at any
time after it has become subject to such reporting requirements), or that it qualifies as a
registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies),
(ii) a copy of the most recent annual or quarterly report of the Company and such other reports and
documents so filed by the Company, and (iii) such other information as may be reasonably requested
in availing any Holder of any rule or regulation of the SEC which permits the selling of any such
securities without registration or pursuant to such form.

          1.12 Assignment of Registration Rights. The rights to cause the Company to register
Registrable Securities pursuant to this Section 1 may be assigned (but only with all related
obligations) by a Holder to a transferee or assignee of such securities that (i) is a subsidiary,
parent, partner, limited partner, retired partner or shareholder of a Holder; (ii) is a

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Holder’s family member or trust for the benefit of an individual Holder; or (iii) after such assignment or
transfer, holds at least 200,000 shares of such securities, provided the Company is, within
a reasonable time after such transfer, furnished with written notice of the name and address of
such transferee or assignee and the securities with respect to which such registration rights are
being assigned; and provided, further, that such assignment shall be effective only
if immediately following such transfer the further disposition of such securities by the transferee
or assignee is restricted under the Securities Act. For the purposes of determining the number of
shares of Registrable Securities held by a transferee or assignee, the holdings of transferees and
assignees of a partnership who are partners or retired partners of such partnership (including
spouses and ancestors, lineal descendants and siblings of such partners or spouses who acquire
Registrable Securities by gift, will or intestate succession) shall be aggregated together and with
the partnership; provided that all assignees and transferees who would not qualify
individually for assignment of registration rights shall have a single attorney-in-fact for the
purpose of exercising any rights, receiving notices or taking any action under Section 1.

          1.13 Limitations on Subsequent Registration Rights. From and after the date of this
Agreement, the Company shall not, without the prior written consent of the Holders of a majority of
the outstanding Registrable Securities (except as otherwise provided in Section 4.2 hereof), enter
into any agreement with any holder or prospective holder of any securities of the Company which
would allow such holder or prospective holder (a) to include such securities in any registration
filed under Section 1.2 hereof, unless under the terms of such agreement, such holder or
prospective holder may include such securities in any such registration only to the extent that the
inclusion of his securities will not reduce the amount of the Registrable Securities of the Holders
which is included or (b) to make a demand for registration of such securities.

          1.14 “Market Stand-Off” Agreement. Each Holder, Founder, Investor and Common
Shareholder (collectively, the “Shareholders”) hereby agrees that, during the period of
duration (up to, but not exceeding, 180 days) specified by the Company and an underwriter of Common
Stock or other securities of the Company, following the effective date of a registration statement
of the Company filed under the Securities Act, it shall not, to the extent requested by the Company
and such underwriter, directly or indirectly sell, offer to sell, contract to sell (including,
without limitation, any short sale), grant any option to purchase or otherwise transfer or dispose
of (other than to donees who agree to be similarly bound) any securities of the Company held by it
at any time during such period except Common Stock included in such registration; provided,
however, that:

               (a) such agreement shall be applicable only to the first such registration statement of the
Company which covers Common Stock (or other securities) to be sold on its behalf to the public in
an underwritten offering; and

               (b) all officers and directors of the Company, all one-percent or greater securityholders, and
all other persons with registration rights (whether or not pursuant to this Agreement) enter into
similar agreements.

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          In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions
with respect to the Registrable Securities of each Shareholder (and the shares or securities of
every other person subject to the foregoing restriction) until the end of such period, and each
Shareholder agrees that, if so requested, such Shareholder will execute an agreement in the form
provided by the underwriter containing terms which are essentially consistent with the provisions
of this Section 1.14.

          Notwithstanding the foregoing, the obligations described in this Section 1.14 shall not apply
to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar
forms which may be promulgated in the future, or a registration relating solely to an SEC Rule 145
transaction on Form S-4 or similar forms which may be promulgated in the future.

          1.15 Termination of Registration Rights. No Holder shall be entitled to exercise any
right provided for in this Section 1 after the earlier of (i) five (5) years following the
consummation of a Qualified IPO, or (ii) such time as Rule 144 or another similar exemption under
the Securities Act is available for the sale of all of such Holder’s shares during a consecutive
three (3)-month period without registration.

     2. Covenants of the Company.

          2.1 Delivery of Financial Statements. The Company shall deliver to each Holder of at
least 200,000 shares of Registrable Securities (other than a Holder reasonably deemed by the
Company to be a competitor of the Company):

               (a) as soon as practicable, but in any event within ninety (90) days after the end of each
fiscal year of the Company, an income statement for such fiscal year, a balance sheet of the
Company and statement of shareholder’s equity as of the end of such year, and a statement of cash
flows for such year, such year-end financial reports to be in reasonable detail, prepared in
accordance with generally accepted accounting principles (“GAAP”), and audited and
certified by an independent public accounting firm of nationally recognized standing selected by
the Company;

               (b) as soon as practicable, but in any event within forty-five (45) days after the end of each
of the first three (3) quarters of each fiscal year of the Company, an unaudited profit or loss
statement, a statement of cash flows for such fiscal quarter and an unaudited balance sheet as of
the end of such fiscal quarter; and

               (d) as soon as practicable, but in any event thirty (30) days prior to the end of each fiscal
year, a budget and business plan for the next fiscal year, prepared on a quarterly basis, and, as soon as prepared, any other budgets or revised budgets prepared by
the Company.

          2.2 Inspection. The Company shall permit each Holder of at least 200,000 shares of
Registrable Securities (except for a Holder reasonably deemed by the Company to be a

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competitor of the Company), at such Holder’s expense, to visit and inspect the Company’s properties, to examine
its books of account and records and to discuss the Company’s affairs, finances and accounts with
its officers, all at such reasonable times as may be requested by the Investor; provided,
however, that the Company shall not be obligated pursuant to this Section 2.2 to provide
access to any information which it reasonably considers to be a trade secret or similar
confidential information.

          2.3 Right of First Offer. Subject to the terms and conditions specified in this
Section 2.3, the Company hereby grants to each Major Investor (as hereinafter defined) a right of
first offer with respect to future sales by the Company of its Shares (as hereinafter defined).
For purposes of this Section 2.3, a “Major Investor” shall mean any person who holds at
least 200,000 shares of Series B, Series C, Series D and/or Series E Preferred Stock (or Common
Stock issued upon conversion of such shares of Series B, Series C, Series D and/or Series E
Preferred Stock), as adjusted for stock dividends, stock splits, reclassifications and the like.
For purposes of this Section 2.3, Major Investor includes any general partners and affiliates of a
Major Investor. A Major Investor that chooses to exercise the right of first offer may designate
as purchasers under such right itself or its partners or affiliates in such proportions as it deems
appropriate.

          Each time the Company proposes to offer any shares of, or securities convertible into or
exercisable for any shares of, any class of its capital stock (for purposes of this Section 2.3,
the “Shares”), the Company shall first make an offering of such Shares to each Major
Investor in accordance with the following provisions:

               (a) The Company shall deliver a notice by certified mail (“Notice”) to the Major
Investors stating (i) its bona fide intention to offer such Shares, (ii) the number of such Shares
to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such Shares.

               (b) Within 15 calendar days after delivery of the Notice, the Major Investor may elect to
purchase or obtain, at the price and on the terms specified in the Notice, up to that portion of
such Shares which equals the proportion that the number of shares of Common Stock issued and held,
or issuable upon conversion and exercise of all convertible or exercisable securities then held, by
such Major Investor bears to the total number of shares of Common Stock then outstanding (assuming
full conversion and exercise of all convertible securities, warrants or options). The Company
shall promptly, in writing, inform each Major Investor that purchases all the shares available to
it (each, a “Fully-Exercising Investor”) of any other Major Investor’s failure to do
likewise. During the ten (10)-day period commencing after receipt of such information, each Fully-Exercising Investor shall be entitled to obtain that portion of
the Shares for which Major Investors were entitled to subscribe but which were not subscribed for
by the Major Investors that is equal to the proportion that the number of shares of Common Stock
issued and held, or issuable upon conversion and exercise of all convertible or exercisable
securities then held, by such Fully-Exercising Investor bears to the total number of shares of
Common Stock then outstanding (assuming full conversion and exercise of all convertible or
exercisable securities, warrants or options).

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               (c) The Company may, during the 45-day period following the expiration of the period provided
in subsection 2.3(b) hereof, offer the remaining unsubscribed portion of the Shares to any person
or persons at a price not less than, and upon terms no more favorable to the offeree than those
specified in the Notice. If the Company does not enter into an agreement for the sale of the
Shares within such period, or if such agreement is not consummated within 60 days of the execution
thereof, the right provided hereunder shall be deemed to be revived and such Shares shall not be
offered unless first reoffered to the Major Investors in accordance herewith.

               (d) The right of first offer in this paragraph 2.3 shall not be applicable (i) to the issuance
or sale of shares of Common Stock (or options therefor) to employees, officers, consultants and
directors, vendors or others with whom the Company conducts business pursuant to a stock option
plan or restricted stock plan approved by the Board of Directors for the primary purpose of
soliciting or retaining their services, (ii) to or after consummation of a Qualified IPO, (iii) to
the issuance of securities pursuant to the conversion or exercise of convertible or exercisable
securities, (iv) to the issuance of securities in connection with a bona fide business acquisition
of or by the Company, whether by merger, consolidation, sale of assets, sale or exchange of stock
or otherwise, or similar transaction, the terms of which are approved by the Board of Directors of
the Company, (v) to the issuance of securities to financial institutions or lessors in connection
with commercial credit arrangements, equipment financings, or similar transactions, or that are for
other than primarily equity financing purposes, (vi) to the issuance or sale of the Series E
Preferred Stock or warrants to purchase the Series E Preferred Stock, (vii) to the issuance of
securities that, with unanimous approval of the Board of Directors of the Company, are not offered
to any existing shareholder of the Company, or (viii) to the issuance of securities in connection
with a transaction approved by the Board of Directors of the Company to an entity as a component of
a business relationship with such entity also involving material manufacturing, marketing,
distribution, product development and/or technology licensing arrangements. In addition to the
foregoing, the right of first offer in this paragraph 2.3 shall not be applicable with respect to
any Investor and any subsequent securities issuance, if (i) at the time of such subsequent
securities issuance, the Investor is not an “accredited investor,” as that term is then defined in
Rule 501(a) under the Securities Act, and (ii) such subsequent securities issuance is otherwise
being offered only to accredited investors.

          2.4 Termination of Covenants.

               (a) The covenants set forth in Sections 2.1 through Section 2.3 shall terminate as to each
Holder and be of no further force or effect (i) immediately prior to the
closing of a Qualified IPO, or (ii) when the Company shall sell, convey, or otherwise dispose
of or encumber all or substantially all of its property or business or merge into or consolidate
with any other corporation (other than a wholly-owned subsidiary corporation) or effect any other
transaction or series of related transactions in which more than fifty percent (50%) of the voting
power of the Company is disposed of, provided that this subsection (ii) shall not apply to
a merger effected exclusively for the purpose of changing the domicile of the Corporation.

               (b) The covenants set forth in Sections 2.1 and 2.2 shall terminate as to each Holder and be
of no further force or effect when the Company first becomes subject to

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the periodic reporting requirements of Sections 13 or 15(d) of the Exchange Act, if this occurs earlier than the events
described in Section 2.4(a).

     3. Restrictions on Transfer.

          3.1 Notice of Sales; Right of First Refusal.

               (a) Should any Shareholder propose to accept one or more bona fide offers (collectively, a
“Purchase Offer”) from any person(s) or entity(ies) to purchase any shares of the Company’s
capital stock or portions thereof held by such Shareholder (for purposes of this Section 3, the
“Shares”) (other than as set forth in Section 3.4 hereof), such Shareholder shall promptly
deliver a notice (the “Notice”) to the Company stating the terms and conditions of such
Purchase Offer including, without limitation, the number of shares of the Company’s capital stock
to be sold or transferred, the nature of such sale or transfer, the consideration to be paid, and
the name and address of each prospective purchaser or transferee. The Company shall then have the
right, exercisable by notice to the selling Shareholder within thirty (30) days after receipt of
the Notice (the “Initial Company Refusal Period”), to exercise a first right to purchase
all or a portion of such Shares (the “Initial Company Right of First Refusal”) on the same
terms and conditions as described in the Notice.

               (b) If the Company does not exercise the Initial Company Right of First Refusal in full and
the sale of the Shares by such Shareholder has been approved by a two-thirds majority of the Board
of Directors of the Company pursuant to Section 3.3 hereof, then promptly after the expiration of
the Initial Company Refusal Period, the Company shall send a written notice, which notice shall
include the Notice from the selling Shareholder (together the “Second Notice”), to each
Investor stating that the Company has chosen not to exercise, in full or in part, the Initial
Company Right of First Refusal. The Company shall then have the right, exercisable by notice to
the selling Shareholder within thirty (30) days after the date of the Second Notice (the
“Subsequent Company Refusal Period”), to exercise a first right to purchase all or a
portion of such Shares (the “Subsequent Company Right of First Refusal”) on the same terms
and conditions as described in the Notice. Each Investor shall have the secondary right, subject
to the Subsequent Company Right of First Refusal, exercisable by notice to the selling Shareholder
and to the Company within twenty (20) days after the Second Notice (the “Refusal Period”),
to exercise a right to purchase such Shares not purchased by the Company (the “Right of First
Refusal”) on the same terms and conditions as described in the Notice and on a pro rata basis,
based upon the number of shares of Common Stock issued and held, or issuable upon
conversion and exercise of all convertible or exercisable securities then held, by such
Investor relative to the aggregate number of shares of Common Stock issued and held, or issuable
upon conversion and exercise of all convertible or exercisable securities then held, by all
Investors; provided that if fewer than all Investors elect to participate, the Shares that
would otherwise be allocated to non-participating Investors shall be allocated to each
participating Investor in a manner such that each participating Investor is entitled to purchase at
least such Investor’s pro rata portion of such unallocated or such different number of Shares as
the participating Investors shall mutually agree. Upon expiration of the Subsequent Company
Refusal Period, the Company will provide notice to all Investors as to whether or not the
Subsequent Company Right of First

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Refusal has been exercised by the Company, and to the extent that it has not, as to whether or not the Right of First Refusal has been exercised by one or more of
the Investors.

          3.2 Failure to Exercise. The failure by the Company or an Investor to exercise the
rights under Section 3.1 or Section 3.3 to purchase any portion of Shares in a sale of Shares made
by a Shareholder shall not affect the Company’s or such Investor’s rights to purchase any portion
of Shares in subsequent sales of Shares by any Shareholder.

          3.3 No Transfers without Board Approval. Except for transfers to the Company pursuant
to Section 3.1 and except as permitted pursuant to Section 3.4, no Shareholder may transfer any
shares of capital stock of the Company (including without limitation to Investors pursuant to
Section 3.1(b)) without first obtaining the written consent to such transfer from a two-thirds
majority of the Company’s Board of Directors, such two-thirds majority in its good faith judgment,
having determined that such transfer would not be detrimental to the interests of the Company and
its shareholders. In addition, as a condition precedent to any such transfer, the transferee must
agree in writing to be bound by the terms of this Section 3.3 as if such transferee were a
Shareholder under this Section 3.3, and to be bound by all other provisions of this Agreement
applicable to the transferor.

          3.4 Permitted Transactions. The provisions of Section 3.1 and Section 3.3 of this
Agreement shall not pertain or apply to:

               (a) any pledge of the Company’s capital stock made by a Shareholder pursuant to a bona fide
loan transaction which creates a mere security interest;

               (b) any bona fide gift;

               (c) any transfer to a Shareholder’s ancestors, descendants or spouse or to a trust for their
benefit;

               (d) any sale or transfer of shares of Common Stock among the Shareholders;

               (e) any sale or transfer by a Shareholder of up to 5% of the total number of shares of Common
Stock held by such Shareholder on the date of this Agreement in
any twelve-month period; provided that the pledgee, transferee or donee (collectively,
the “Permitted Transferees”) shall furnish the other Shareholders with a written agreement
to be bound by and comply with all provisions of this Agreement applicable to the Shareholders; or

               (f) any transfer by a Shareholder that is a partnership to a partner of such partnership or a
retired partner of such partnership who retires after the date hereof, or to the estate of any such
partner or retired partner or the transfer by gift, will or intestate succession of any partner to
his or her spouse or to the siblings, lineal descendants or ancestors of such partner or his or her
spouse.

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          3.5 Prohibited Transfers. Any attempt by a Shareholder to transfer shares of the
Company in violation of Section 3 hereof shall be void, and the Company agrees it will not effect
such a transfer nor will it treat any alleged transferee as the holder of such shares without the
written consent of the holders of a two-thirds majority of the Shareholders, voting as a single
class on a fully diluted, as-converted basis, and the written consent of a two-thirds majority of
the Board of Directors of the Company.

          3.6 Legended Certificates. Each certificate representing shares of the Series A,
Series B, Series C, Series D and Series E Preferred Stock and Common Stock now owned by the
Shareholders or issued to any Permitted Transferee pursuant to Section 3.4 shall bear the following
legend:

“THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES REPRESENTED BY THIS
CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A CERTAIN RESTRICTIONS
AGREEMENT BY AND BETWEEN THE SHAREHOLDER, THE CORPORATION AND CERTAIN HOLDERS OF
COMMON AND PREFERRED STOCK OF THE CORPORATION. COPIES OF SUCH AGREEMENT MAY BE
OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY OF THE CORPORATION.”

     The foregoing legend shall be removed upon termination of this Agreement in accordance with
the provisions of Section 3.7.

          3.7 Termination. The obligations and restrictions contained in this Section 3 shall
terminate upon the earliest to occur of any one of the following events (and shall not apply to any
transfer by a Shareholder in connection with any such event):

               (a) the liquidation, dissolution or indefinite cessation of the business operations of the
Company;

               (b) the execution by the Company of a general assignment for the benefit of creditors or the
appointment of a receiver or trustee to take possession of the property and assets of the Company;

               (c) the consummation of a Qualified IPO; or

               (d) the sale, conveyance, disposal, or encumbrance of all or substantially all of the
Company’s property or business or the Company’s merger into or consolidation with any other
corporation (other than a wholly-owned subsidiary corporation) or if the Company effects any other
transaction or series of related transactions in which more than fifty percent (50%) of the voting
power of the Company is disposed of; provided that this Section 3.7(d) shall not apply to a
merger effected exclusively for the purpose of changing the domicile of the Company.

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     4. Miscellaneous.

          4.1 Successors and Assigns. Except as otherwise provided in this Agreement, the terms
and conditions of this Agreement shall inure to the benefit of and be binding upon the respective
permitted successors and assigns of the parties (including transferees of any of the Preferred
Stock or any Common Stock issued upon conversion thereof). Nothing in this Agreement, express or
implied, is intended to confer upon any party other than the parties hereto or their respective
successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this
Agreement, except as expressly provided in this Agreement.

          4.2 Amendments and Waivers. Any term of this Agreement may be amended or waived only
with the written consent of the Company and the holders of a majority of the Registrable Securities
then outstanding, not including the Founders’ Stock; provided that if such amendment has
the effect of affecting the Founders’ Stock (i) in a manner different than securities issued to the
Investors and (ii) in a manner adverse to the interests of the holders of the Founders’ Stock, then
such amendment shall require the consent of the holder or holders of a majority of the Founders’
Stock. Notwithstanding the foregoing, subsequent Purchasers (as defined under the Purchase
Agreement) of the Company’s Series E Preferred Stock under the Purchase Agreement or any Addendum
Agreement thereto will be added as a party to this Agreement as an Investor without having to
obtain the consents set forth above and shall be bound by and entitled to the terms, benefits and
conditions herein by the execution and delivery of a signature page to this Agreement. Any
amendment or waiver effected in accordance with this paragraph shall be binding upon each holder of
any Registrable Securities then outstanding, each future holder of all such Registrable Securities,
and the Company.

          4.3 Notices. Unless otherwise provided, any notice required or permitted by this
Agreement shall be in writing and shall be deemed sufficient upon delivery, when delivered
personally or by overnight courier or sent by telegram or fax with electronic confirmation
received, or forty-eight (48) hours after being deposited in the U.S. mail, as certified or
registered mail, with postage prepaid, and addressed to the party to be notified at such party’s
address or fax number as set forth on the signature page or Exhibits hereto or as subsequently
modified by written notice.

          4.4 Severability. If one or more provisions of this Agreement are held to be
unenforceable under applicable law, the parties agree to renegotiate such provision in good faith.
In the event that the parties cannot reach a mutually agreeable and enforceable replacement for
such provision, then (a) such provision shall be excluded from this Agreement, (b) the balance of
this Agreement shall be interpreted as if such provision were so excluded and (c) the balance of
this Agreement shall be enforceable in accordance with its terms.

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          4.5 Governing Law. This Agreement and all acts and transactions pursuant hereto shall
be governed, construed and interpreted in accordance with the laws of the State of Washington,
without giving effect to principles of conflicts of laws.

          4.6 Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute one and the same
instrument.

          4.7 Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement.

          4.8 Aggregation of Stock. All shares of the Preferred Stock held or acquired by
affiliated entities or persons shall be aggregated together for the purpose of determining the
availability of any rights under this Agreement.

          4.9 Entire Agreement. This Agreement (including the Exhibits hereto, if any)
constitutes the entire understanding among the parties with regard to the subjects hereof and
thereof.

          4.10 Telecopy Execution and Delivery. A facsimile, telecopy or other reproduction of
this Agreement may be executed by one or more parties hereto, and an executed copy of this
Agreement may be delivered by one or more parties hereto by facsimile or similar electronic
transmission device pursuant to which the signature of or on behalf of such party can be seen, and
such execution and delivery shall be considered valid, binding and effective for all purposes. At
the request of any party hereto, all parties hereto agree to execute an original of this Agreement
as well as any facsimile, telecopy or other reproduction hereof.

          4.11 Arbitration. The parties agree to attempt in good faith to negotiate a
settlement of any and all controversies, claims, or disputes arising out of, relating to, or
resulting from this Agreement. If, after such good faith negotiation, the parties are not able to
reach a settlement, any and all of such controversies, claims, or disputes arising out of, relating
to, or resulting from this Agreement shall be subject to binding arbitration. Such arbitration
shall take place in Seattle, Washington and will be administered by the American Arbitration Association
(“AAA”) in accordance with its Rules for the Resolution of Commercial Disputes. The
parties agree that the arbitrator shall have the power to decide any motions brought by any party
to the arbitration, including motions for summary judgment and/or adjudication and motions to
dismiss and demurrers, prior to any arbitration hearing. The parties also agree that the
arbitrator shall have the power to award any remedies, including attorneys’ fees and costs,
available under applicable law, provided that the prevailing party in any arbitration shall be
entitled to its reasonable attorneys fees and costs. The decision of the arbitrator shall be in
writing.

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Arbitration shall be the sole, exclusive and final remedy for any dispute under this
Agreement and the decision of the arbitrator may be entered by a party in any court or forum, state
or federal, being of competent jurisdiction. Accordingly, no party will be permitted to pursue
court action regarding this Agreement except as expressly permitted in the preceding sentence.
Notwithstanding the foregoing, each party retains the right to seek injunctive relief to prevent a
breach, threatened breach or continuing breach of this Agreement that would cause irreparable
injury to such party.

          4.12 Termination and Supersession. This Agreement replaces and supersedes the Prior
Agreement, and the Prior Agreement is hereby terminated.

[Signature Page Follows]

-21-

 

     The parties have executed this Amended and Restated Investors’ Rights Agreement as of the date
first above written.

	 	 	 	 	 
	 	COMPANY:

OMEROS CORPORATION

 	 
	 	By:  	/s/ Gregory A. Demopulos	 
	 	 	Gregory A. Demopulos, M.D. 	 
	 	 	Chairman of the Board, President and

Chief Executive Officer

Address:      1420 Fifth Ave., Suite 2600
Seattle, WA  98101

Fax:  (206) 264-7856 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

	 	 	 	 	 
	 	SERIES E INVESTOR:

 	 
	 	
 	 
	 	(Investor) 	 
	 	 	 
	 
	 	 	 
	 	By:  	
 	 
	 	 	Name:  	 	 
	 	 	 	(print)	 
	 	 	Title:  	 	 
	 	 	 	(if applicable)	 
	 	 	Address:  	 	 
	 
	 	 	Fax:  	 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

	 	 	 	 	 
	 	FOUNDERS:

 	 
	 	
 	 
	 	H. Raymond Cairncross 	 
	 
	 	Address:

Fax: 	 
	 
	 	 	 
	 	/s/ Gregory A. Demopulos	 
	 	Gregory A. Demopulos, M.D. 	 
	 
	 	Address:

Fax: 	 
	 
	 	 	 
	 	
 	 
	 	George Kargianis 	 
	 
	 	Address:

Fax: 	 
	 
	 	 	 
	 	
 	 
	 	Pamela Pierce Palmer, M.D., Ph.D. 	 
	 
	 	Address:

Fax: 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

	 	 	 	 	 
	 	SERIES A INVESTOR:

 	 
	 	
 	 
	 	(Investor) 	 
	 	 	 
	 
	 	 	 
	 	By:  	
 	 
	 	 	Name:  	 	 
	 	 	 	(print)	 
	 	 	Title:  	 	 
	 	 	 	 	 
	 	 	Address:  	 	 
	 
	 	 	Fax:  	 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

	 	 	 	 	 
	 	SERIES B INVESTOR:

 	 
	 	
 	 
	 	(Investor) 	 
	 	 	 
	 
	 	 	 
	 	By:  	
 	 
	 	 	Name:  	 	 
	 	 	 	(print)	 
	 	 	Title:  	 	 
	 	 	 	 	 
	 	 	Address:  	 	 
	 
	 	 	Fax:  	 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

	 	 	 	 	 
	 	SERIES C INVESTOR:

 	 
	 	
 	 
	 	(Investor) 	 
	 	 	 
	 
	 	 	 
	 	By:  	
 	 
	 	 	Name:  	 	 
	 	 	 	(print)	 
	 	 	Title:  	 	 
	 	 	 	 	 
	 	 	Address:  	 	 
	 
	 	 	Fax:  	 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

	 	 	 	 	 
	 	SERIES D INVESTOR:

 	 
	 	
 	 
	 	(Investor) 	 
	 	 	 
	 
	 	 	 
	 	By:  	
 	 
	 	 	Name:  	 	 
	 	 	 	(print)	 
	 	 	Title:  	 	 
	 	 	 	 	 
	 	 	Address:  	 	 
	 
	 	 	Fax:  	 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

	 	 	 	 	 
	 	COMMON SHAREHOLDER:

 	 
	 	/s/ Gregory A. Demopulos	 
	 	(Common Shareholder) 	 
	 	 	 
	 
	 	 	 
	 	By:  	
 	 
	 	 	Name:  	 	 
	 	 	 	(print)	 
	 	 	Title:  	 	 
	 	 	 	 	 
	 	 	Address:  	 	 
	 
	 	 	Fax:  	 	 
	 

SIGNATURE PAGE TO OMEROS CORPORATION’S

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

Exhibit A

SERIES E INVESTORS

Marie Stanislaw and Steve Abel

Charles L. Anderson

Dean E. and Lynda M. Anderson JTWROS

Richard W. Anderson

Charles C. Andonian

Andonian Family GST Trust

Martin Andrews

Robert M. Arnold

William and Sylvia Bailey

David H. and Jean Barber

Larry L. Barokas

Alan Bartelheimer

Robert and Alice Bender

Thad Berger

William Blum

Stephen K. Boone

BPEF 2 Omeros Partners, LP

Harold D. Brown

Frederick S. & Jane H. Buckner

Christine Buecker IRA Charles Schwab & Co., Inc. Cust.

John Burgess

 

 

Mark Callaghan

Cheve Famille LLC

Chicago Private Investments, Inc.

Ching Defined Benefit Pension Plan

Ching Revocable Trust

Jeff & Janee Christianson

Delores Christianson

Ivan Christianson

CIBC Trust Company (Bahamas) Limited as Trustee of T-2100

Alan and Margaret Cornell

Dale E. Cowles

Bennett and Shirley LaFollette Cozadd

R. Michael Creighton

Critchfield Investment Partners, L.P.

Brian Crynes

Robert Curley

Jann Curley

Michael and Martha Davidson

Harold L. and Pride E. Davies

Patrick Day

M.R. de Carvalho

Delaware Charter Guarantee & Trust Co., Trustee FBO, Jeff Esfeld/Roth IRA

Dennis Shay Co. Profit Sharing Trust

Moss Adams LLP DEF BEN PEN PL #95 U/A DTD 1/31/89, Edward C. Drosdick, TTEE

 

 

Richard R. and Marilyn B. Dunn

Richard M. Elkus

Steven and Pauline Elliott

Kevin Elliott

Ruth and John Fay

Robert Feldman

First Washington PSP, DTD 7/1/84 FBO Philip F. Frank Jr., Philip F. Frank Jr. Trustee

Drew & Kristin Fletcher

Barbara R. and Robert M. Frayn, Jr.

Frederick Goldberg Family, LLC

Stuart Fuchs IRA

Gary and Della Furukawa

Michael Gano

Eduardo Garcia & Jane Hoerig

Gretchen Garth

Bill and Lindy Gaylord

Gregory and Susan George

Jonathan R. Goldner

Dian Goldberg

Frederick Goldberg

Stanley and Carolyn Graves

Grosvenor Special Ventures IV, LP

Frank B. & Joan Hall

Scott & Kerry Hall

 

 

Bradley Harris

Tom and Jo Ann R. Hornsten

Arthur and Janet Stanton Hurd

Peter Indelicato

Walter R. Ingram

Sam and Naomi Israel

Donald M. Jasper

Donald and Beverly Jefferson

Scott and Susan Jennings

JLB Investment Company

Kanter Family Foundation (IL Corp.)

Gloria Katz Revocable Trust

Bruce Keithly IRA Charles Schwab & Co., Inc. Cust.

David Kenyon

Edward B. Kibble

Donald E. Kline

Robert Kollack

Koppes Family Revocable Trust, Alan W. Koppes Trustee

Dennis J. Kvidera

Kvidera Living Trust

Henry Liebman

Rex Lund

Louis Lundquist

Kathy Lusher

 

 

Chai Mann

Pamela B McCabe

Patrick and Michele McCarthy

Karen McDonald

Susan Melodia

Lawrence Meurk

Joanne K. Meyers

Randee Sue Meyers

Michael C. Mossman

MST Partners

Douglas Norberg

Novel BioVentures LLC

Richard J. and Vonda M. Olson

B. Delores O’Neil

Thomas Orvald

James Osgood

Donald F. Padelford

Christohper G Pallis

Chris N Pallis

Christopher G. Pallis IRA

Vasillios N. Pallis

Patricia L. Pedegana

Donald & Laura Peterson Petersen, JTWROS

Donald E. Petersen

 

 

Brent P. Pistorese and Linda D. Pistorese Revocable Living Trust

Hasso Plattner

Kathleen Popham

Prentice Family Partnership

Prime Time Partners, L.P.

Prime Time Partners

Herbert Pruzan

Harry Pryde

Paul A. Raidna

Peter and Debra Rettman

George Reynolds

Bradley G. Rich

Ring Revocable Trust, Lawrence W. Ring, Trustee

R.E. Rohde

Dan Rome

John C. Rosling

Donn Rowe

John and Linda Schukar

George E.S. Seligman

Steven L. Sherman

Sherwood Associates, LLC

Lorraine Smith

Linda Barker Spear

John M. Spicer

 

 

Robert H and Rita A. Splan

Greg and Vicky Stamolis

Chris W. Strand IRA Rollover UTA Charles Schwab & Co. Inc.

Joseph P. & D. Dyann Strecker

Stuart Sulman

Scott Sulman

Summit Capital Partners, L.P.

Michael J Swindling

Janet Taggares

Tenwall Investment Co.

Brad Thompson

Richard Toll

Wells Fargo Bank IRA C/F Richard W. Tschetter

Gregory P. Vernon

Trevor Vernon

Jerome K. Walsh

Stephen J. Warner

Washington Research Foundation

Gary Waterman

Bruce E. Watterson

Michael Weaver

Jon D. Wheeler

Brad Williamson

Charlotte Witter

 

 

Malcolm G. Witter IRA/Bear Stearns Custodian

Olivia Witter

 

 

Exhibit B

SERIES A INVESTORS

Gary R. and Mitzi M. Aspiri

Aspiri Enterprises LLC

Jon A. and Julie P. Barwick

Thomas W. and Ann M. Barwick

David and Virginia Broudy

Thomas J. Cable Defined Benefit Retirement Plan

Larry W. and Mary K. Crocker, JTWROS

Peter A. Demopulos, M.D.

Milton and Nancy English

Barbara R. and Robert M. Frayn, Jr.

Steven and Anne Gillis, JTWROS

E. Cary Halpin D.D.S., P.S.

Profit Sharing Plan

Chauncey F. Lufkin

Chauncey F. Lufkin, as trustee for

Wende Lufkin

Chauncey F. Lufkin, as trustee for

Lisa L. Collins

Chauncey F. Lufkin, as trustee for

Chauncey F. Lufkin, Jr.

Chauncey F. Lufkin, as trustee for

Andrew Lufkin

Chris G. and Vasiliki L. Pallis

Harry Pryde

 

 

Wayne E. Quinton

William J. Rex

T2G Limited Partnership

 

 

Exhibit C

SERIES B INVESTORS

Charles L. Anderson

Travis S. Ashby

Aspiri Enterprises LLC

Milton A. Barrett, Jr. and Jane S. Barrett

Andrew J. Berndt

Bost & Co. FBO Leonard A. Yerkes

John M. Brenneman

Susan E. Brock-Utne

Thomas F. and Joyce S. Broderick

Thomas J. Cable

City National Bank

TTEE FBO DWT/James

City National Bank Bank Trustee

DWT FBO Bruce Lamka

Dale E. Cowles

Critchfield Investment Partners, L.P.

Thomas E. Doelger

George T. Drugas, M.D. & Heidi J. Drugas

Peter W. Eising

Ruth G. Fleischmann

Francis D. Galey

Gretchen Garth

William H. Gates, Jr.

 

 

Jerry L. and Mary E. Gatewood

Jonathan R. Goldner

Joshua Starbuck Goldner

Marcia M. Goldner

Steven Goldner

As custodian for Julia Starbuck Goldner

Steven Craig Goldner

Dan M. and Wendy Ershig Guy III

Frank B. and Joan B. Hall

Scott and Kerry Hall

Patrick M. and Melinda G. Hannigan

Tom and JoAnn Hornsten

Donn and Abigail Hutchins

Barbara Olivia Jackson

Blayne Johnson

David Kenyon

Edward R. Kibble

Scott Land

Captain Thomas Latsoudis

Chauncey F. Lufkin

Rex Lund

Pamela B. McCabe

Craig McCallum

Daniel J. McHugh

Patricia A. Milbank

 

 

Patrick R. Milbank

MST Partners — Leonard H. Shapiro

Dallas L. Otter

Carol F. Padelford

Chris G. and Vasiliki L. Pallis

Panos Brothers Capital, LLC

Patricia L. Pedegana

Piper Jaffray, Inc. as custodian for the benefit of (FBO)

John Hopkins

Arlen I. Prentice

David Prentice

Quarry Capital Corporation

Paul A. Raidna

Robert J. and Terri L. Rusch, Jr.

John B. Scates

Craig E. Sherman

A.G. Edwards & Sons, Inc. Custodian for Daniel A. Sherman, M.D.,

FBO Daniel A. Sherman M.D. Profit Sharing Plan

Vicki L. Sheron

Christopher F. Smith

Gary B. and Marilyn R. Smith

Beth Starbuck

Craig W. and Valerie A. Stewart

STF III, L.P.

Joseph P. Strecker and D. Dyann Strecker

 

 

Paul and Mary Elizabeth Stritmatter

A.L. and Lucy J. Sytman

T2G Limited Partnership

David R. Toll

Trans Cosmos USA, Inc.

TTEE Robert W. Bethke Living Trust U/A DTD August 22, 1986

VLG Investments 1998

Wayne C. Wager

Christian Wedell

Malcolm G. Witter

Robert L. and Valerie R. Yurina

 

 

Exhibit D

SERIES C INVESTORS

Douglas D. Adkins

Alchemy Partners, LLC

Charles L. Anderson

Richard W. Anderson

Travis Ashby

Aspiri Enterprises LLC

Milton A. Barrett, Jr. and Jane S. Barrett

Roger C. Berger, Marital Trust

Andrew J. Berndt

John Brenneman

Deborah Brunton

Frederick S. and Jane H. Buckner

Thomas J. Cable

Ivan and Delores Christianson

Jeff and Janee Christianson

CIBC World Markets as custodian for

Dr. Lynn Staheli IRA

Reed Corry

Dale L. Cowles

Critchfield Investment Partners, L.P.

CSK-4 Investment Fund

Dean Witter Reynolds custodian for

Marianne LoGerfo IRA Standard

 

 

Delphic Navigation Company Limited

Thomas E. Doelger

Chris T. Economou

Ershig Family Ltd. Partnership

Ruth G. Fleischmann

Drew and Kristin Fletcher

Edward D. Fugo, Jr.

John Gerondis

James Giammatteo

Gary Glant

Jonathan Goldner

Marcia Goldner

Steven Goldner as custodian for

Joshua Goldner

Steven Goldner as custodian for

Julia Goldner

Thomas Green

Dan M. and Wendy Ershig Guy III

H&L Investment Company

Frank B. and Joan B. Hall

Scott and Kerry Hall

Charles K. Hanson

Leroy E. Hood, M.D., Ph.D.

Tom and JoAnn Hornsten

Grady Hughes

Donn and Abigail Hutchins

 

 

Bost & Co. FBO

Leonard A. Yerkes III

Itochu Finance Corporation

Barbara Olivia Jackson

Jerome M. Johnson

Makoto Kaneshiro

William T. Karr

John Keister

David Kenyon

Sanjeev Khanna

Edward B. Kibble

Pamela L. Kirkpatrick

Donald E. Kline

Larry Kopp

Bruce Lamka and Susan Duffy

The Lawrence Trust as dated Aug. 3, 1989,

as amended June 6, 1997 and Sept. 16, 1998

Michael Ludwig

Luna Capital LLC I

Pamela and Robert McCabe

Daniel J. McHugh

Marion Colby McNamara

Joanne K. Meyers

Mission Management and Trust FBO

Lawrence Ring IRA Account 7467

Robert H. Monroe

 

 

MST Partners — Leonard H. Shapiro

Richard J. and Vonda Olson

Gary Oppenheim

PAC Partnership

Carol F. Padelford

Donald F. Padelford

Chris Pallis

Patricia L. Pedegana

Donald E. Petersen and Laura J. Peterson, JTWROS

David Pienkowski

Brent and Linda Pistorese

Prentice Family Partnership

George A. and Sara A. Reynolds

John B. Scates

Scott E. Scribner

Martin Selig

Steven L. and Judith F. Sherman

Vicki L. Sheron

Geoffrey B. Shilling

John M. Spicer

Robert H. Splan

Survivors Trust Dated 7/31/93

Craig W. Stewart

Craig W. and Valerie A. Stewart

Harry G. Stewart

 

 

STF III, L.P.

Joseph P. Strecker IRA 8566-1600

Joseph P. and D. Dyann Strecker

D. Dyann Strecker IRA 8566-1258

Steve and Lori Sweningson

Michael Swindling

Tranceka, LLC

Trans Cosmos USA, Inc.

Geoffrey P. and Judith K. Vernon

Joseph R. Vitulli

Bruce E. Watterson

Malcolm G. Witter

 

 

Exhibit E

SERIES D INVESTORS

Douglas D. Adkins

Richard W. Anderson

Aspiri Enterprises LLC

Thomas W. Barwick

Catherine K. Boshaw

Frederick S. and Jane H. Buckner

Richard and Sallie Burhans

Mark Callaghan

Nicole Chitnis

Jeff and Janee Christianson

Ivan and Delores Christianson

Reed Corry

Mary E. Drobka

Georgette Essad

Gretchen Fava

Drew and Kristin Fletcher

Robert M. Frayne, Jr. and Barbara R. Frayne

Francis D. Galey

Gary Glant

Eunice Kensinger Goldner

Eunice Kensinger Goldner as custodian for

Julia Starbuck Goldner under the UGMA

Marcia M. Goldner

 

 

Jonathan R. Goldner

Richard D. Goldner

Steven C. Goldner

Eunice Kensinger Goldner as custodian for

Joshua Starbuck Goldner under the UGMA

Dan M. and Wendy Ershig Guy, III

H&L Investment Company

David E. Hartman

John M. Hopkins

Tom R. Hornsten

Grady M. Hughes

Barbara Olivia Jackson

City National Bank Trustee FBO DWT/Thomas James

Donald M. Jasper

Donald S. and Beverly J. Jefferson JTWROS

Jerome M. Johnson

John Keister

Russell C. Keithly

Edward B. Kibble

Larry S. Kopp

Duane and Suzanne Koxlien

Bruce Lamka and Susan Duffy

Joanne K. Meyers

Michele K. McCarthy Revocable Trust

Michele McCarthy Trustee

Karen McDonald

 

 

Michael C. Mossman

MST Partners

Richard J. and Vonda M. Olson

Donald F. Padelford

Chris Pallis

Donald E. Petersen and Laura J. Peterson, JTWROS

David Pienkowski

Brent P. Piesterese and Linda D. Piesterese Revocable Living Trust

Arthur C. III and Kathleen Popham

Prentice Family Partnership

Paul A. Raidna

George A. and Sara A. Reynolds

Bradley G. Rich

John C. Rosling

George E.S. Seligman

Robert H. Splan Survivors Trust

Steven L. Sherman

Staheli, Inc., Profit Sharing Trustees: Lynn and Lana Staheli

Beth Starbuck

Joseph P. and D. Dyann Strecker

Summit Capital Partners, L.P.

Michael J. Swindling

Janet Taggares

Tranceka, LLC

J. Joseph Veranth Rollover IRA

 

 

Gregory P. Vernon

Trevor Vernon

Joseph R. Vitulli

Malcolm G. Witter

Robert L. and Valerie R. Yurina

 

 

Exhibit F

COMMON SHAREHOLDERS

Aspiri Enterprises LLC

Scott T. Bell*

John Brenneman

Thomas F. Broderick

H. Raymond Cairncross

H. Raymond Cairncross as Custodian for Caitlin D. Cairncross*

H. Raymond Cairncross as Custodian for Christian H. Cairncross*

Terrence I. Danysh

Gregory A. Demopulos, M.D.

William W. Ericson*

Demopulos Family Trust

Janet Garrow*

Joshua Gebhardt*

Gail E. Gillenwater*

John W. Hempelmann*

Jeffrey Herz*

George Kargianis*

Marcia S. Kelbon*

Craig T. Kobayashi*

Donald E. Marcy

James W. McGinity*

Allison and Todd McIntyre*

 

 

John McKay*

Mark Mooney*

Eoin O’Leary*

George Pallis*

Themio Pallis*

Pamela A. Pierce-Palmer, M.D., Ph.D.

J. Thomas Richardson*

Dawson Taylor*

David R. Toll

Tranceka, LLC

Daniel C. Vaughn*

Rachel A. Weiss*

 

			
	*	 	Shall not be deemed a Common Shareholder pursuant to this Agreement until such time as such person
or entity shall have executed a counterpart signature page to this Agreement.exv10w1

 

Exhibit 10.1

INDEMNIFICATION AGREEMENT

     This
Indemnification Agreement (this “Agreement”) is made as of _________, ___
by
and between Omeros Corporation, a Washington corporation (the “Company”), and
_________
(“Indemnitee”), for good and valuable consideration as set forth below.

RECITALS

     A. Indemnitee is an officer or director of the Company and in such capacity is performing
valuable services for the Company.

     B. The Company recognizes the importance, and increasing difficulty, of obtaining adequate
liability insurance coverage for its directors, officers, employees, agents and fiduciaries.

     C. The Company further recognizes that, at the same time as the availability and coverage of
such insurance has become more limited, litigation against corporate directors, officers,
employees, agents and fiduciaries has continued to increase.

     D. As of the date hereof, the Company has provisions for indemnification of its directors and
officers in Article 12 of its Articles of Incorporation (the “Articles of Incorporation”)
and Section 10 of its Bylaws (the “Bylaws”), which provide for indemnification of the
Company’s directors and officers to the fullest extent permitted by the Washington Business
Corporation Act (the “Statute”).

     E. The Bylaws and the Statute specifically provide that they are not exclusive, and thereby
contemplate that contracts may be entered into between the Company and the members of its Board of
Directors and its officers with respect to indemnification of such directors and officers.

     F. The Bylaws provide that the Company may maintain, at its expense, insurance to protect
itself and any of its directors and officers against liability asserted against such persons
incurred in such capacity whether or not the Company has the power to indemnify such persons
against the same liability under Section 23B.08.510 or .520 of the Statute (as defined below) or a
successor statute.

     G. In order to induce Indemnitee to continue to serve as an officer and/or director, as the
case may be, of the Company, the Company has agreed to enter into this Agreement with Indemnitee.

AGREEMENT

     In consideration of the recitals above, the mutual covenants and agreements herein contained,
and Indemnitee’s continued service as an officer and/or director, as the case may be, of the
Company after the date hereof, the parties to this Agreement agree as follows:

 

 

     1. Indemnity of Indemnitee

          (a) Scope. The Company agrees to hold harmless and indemnify Indemnitee to the full
extent permitted by law, without regard to the limitations in RCW 23B.08.510 through 23B.08.550 and
23B.08.560(2) and notwithstanding that such indemnification is not specifically authorized by this
Agreement, the Company’s Articles of Incorporation, the Bylaws, the Statute or otherwise.

          (b) Changes to Indemnification Right. In the event of any change, after the date of
this Agreement, in any applicable law, statute or rule regarding the right of a Washington
corporation to indemnify a member of its board of directors or an officer, such changes, to the
extent that they would expand Indemnitee’s rights hereunder, shall be within the purview of
Indemnitee’s rights and the Company’s obligations hereunder, and, to the extent that they would
narrow Indemnitee’s rights hereunder, shall be excluded from this Agreement; provided, however,
that any change that is required by applicable laws, statutes or rules to be applied to this
Agreement shall be so applied regardless of whether the effect of such change is to narrow
Indemnitee’s rights hereunder.

          (c) Nonexclusivity. The indemnification provided by this Agreement shall not be
deemed exclusive of any rights to which Indemnitee may be entitled under the Company’s Articles of
Incorporation, the Bylaws, any agreement, any vote of shareholders or disinterested directors, the
Statute, or otherwise, whether as to action in Indemnitee’s official capacity or otherwise.

          (d) Additional Indemnity. If Indemnitee was or is made a party, or is threatened to
be made a party, to or is otherwise involved (including, without limitation, as a witness) in any
Proceeding (as defined below), the Company shall hold harmless and indemnify Indemnitee from and
against any and all losses, claims, damages, costs, liabilities, expenses (including attorneys’
fees), judgments, fines, ERISA excise taxes or penalties, amounts paid in settlement (if such
settlement is approved in advance by the Company, which approval shall not be unreasonably
withheld) actually and reasonably incurred by Indemnitee in connection with such Proceeding
(collectively, “Damages”) if Indemnitee acted in good faith and in a manner Indemnitee
reasonably believed to be in or not opposed to the best interests of the Company, and, with respect
to any criminal action or proceeding, had no reasonable cause to believe Indemnitee’s conduct was
unlawful.

          (e) Definition of Proceeding. For purposes of this Agreement, “Proceeding”
shall mean any actual, pending or threatened or completed action, suit, claim, investigation,
hearing, proceeding or alternative dispute resolution mechanism, whether civil, criminal,
administrative or investigative and whether formal or informal, in which Indemnitee is, was or
becomes involved by reason of the fact that Indemnitee is or was a director, officer, employee or
agent of the Company or that, being or having been such a director, officer, employee or agent,
Indemnitee is or was serving at the request of the Company as a director, officer, partner,
employee, trustee or agent of another corporation or of a partnership, joint venture, trust or
other enterprise (collectively a “Related Company”), including service with respect to an
employee benefit plan, whether the basis of such proceeding is alleged action (or inaction) by
Indemnitee in an official capacity as a director, officer, employee, partner, trustee or agent or
in any other capacity while serving as a director, officer,

-2-

 

employee, partner, trustee or agent; provided, however, that, except with respect to an action
to enforce the provisions of this Agreement, Proceeding shall not include any action, suit, claim
or proceeding instituted by or at the direction of Indemnitee unless such action, suit, claim or
proceeding is or was authorized by the Company’s Board of Directors.

          (f) Determination of Entitlement. In the event that a determination of Indemnitee’s
entitlement to indemnification is required pursuant to Section 23B.08.550 of the Statute or any
successor thereto or pursuant to other applicable law, the appropriate decision-maker shall make
such determination; provided, however, that Indemnitee shall initially be presumed in all cases to
be entitled to indemnification, unless the Company shall deliver to Indemnitee written notice of a
determination that Indemnitee is not entitled to indemnification within twenty (20) days of the
Company’s receipt of Indemnitee’s initial written request for indemnification.

          (g) Survival. The indemnification provided under this Agreement shall apply to any
and all Proceedings, notwithstanding that Indemnitee has ceased to be a director, officer,
employee, trustee or agent of the Company or a Related Company.

     2. Expense Advances

          (a) Generally. The right to indemnification of Damages conferred by Section 1 shall
include the right to have the Company pay Indemnitee’s expenses in any Proceeding as such expenses
are incurred and in advance of such Proceeding’s final disposition (such right is referred to
hereinafter as an “Expense Advance”). Any Expense Advance to be made under this Agreement
shall be paid by the Company to Indemnitee within twenty (20) days following delivery of a written
request therefor by Indemnitee to the Company.

          (b) Conditions to Expense Advance. The Company’s obligation to provide an Expense
Advance is subject to the following conditions:

               (i) Undertaking. If the Proceeding arose in connection with Indemnitee’s service as a
director and/or officer of the Company (and not in any other capacity in which Indemnitee rendered
service, including service to any Related Company), then Indemnitee or his or her representative
shall have executed and delivered to the Company an undertaking, which need not be secured and
shall be accepted without reference to Indemnitee’s financial ability to make repayment, by or on
behalf of Indemnitee to repay all Expense Advances if and to the extent that it shall ultimately be
determined by a final, unappealable decision rendered by a court having jurisdiction over the
parties and the question that Indemnitee is not entitled to be indemnified for such Expense Advance
under this Agreement or otherwise. No interest shall be charged on any obligation to reimburse the
Company for an Expense Advance.

               (ii) Cooperation. Indemnitee shall give the Company such information and cooperation
as it may reasonably request and as shall be within Indemnitee’s power.

               (iii) Affirmation. Indemnitee shall furnish, upon request by the Company and if
required under applicable law, a written affirmation of Indemnitee’s good faith belief that any
applicable standards of conduct have been met by Indemnitee.

-3-

 

     3. Procedures for Enforcement

          (a) Enforcement. In the event that a claim for indemnity, an Expense Advance or
otherwise is made hereunder and is not paid in full within sixty (60) days (twenty (20) days for an
Expense Advance) after written notice of such claim is delivered to the Company, Indemnitee may,
but need not, at any time thereafter bring suit against the Company to recover the unpaid amount of
the claim (an “Enforcement Action”).

          (b) Presumptions in Enforcement Action. In any Enforcement Action the following
presumptions (and limitation on presumptions) shall apply:

               (i) The Company shall conclusively be presumed to have entered into this Agreement and assumed
the obligations imposed on it hereunder in order to induce Indemnitee to serve or continue to serve
as an officer and/or director of the Company;

               (ii) Neither (A) the failure of the Company (including the Company’s Board of Directors,
independent or special legal counsel or the Company’s shareholders) to have made a determination
prior to the commencement of the Enforcement Action that indemnification of Indemnitee is proper in
the circumstances nor (B) an actual determination by the Company, its Board of Directors,
independent or special legal counsel or shareholders that Indemnitee is not entitled to
indemnification shall be a defense to the Enforcement Action or create a presumption that
Indemnitee is not entitled to indemnification hereunder; and

               (iii) If Indemnitee is or was serving as a director, officer, employee, trustee or agent of a
corporation of which a majority of the shares entitled to vote in the election of its directors is
held by the Company or in an executive or management capacity in a partnership, joint venture,
trust or other enterprise of which the Company or a wholly owned subsidiary of the Company is a
general partner or has a majority ownership, then such corporation, partnership, joint venture,
trust or enterprise shall conclusively be deemed a Related Company and Indemnitee shall
conclusively be deemed to be serving such Related Company at the request of the Company.

          (c) Attorneys’ Fees and Expenses for Enforcement Action. In the event Indemnitee is
required to bring an Enforcement Action, the Company shall indemnify and hold harmless Indemnitee
against all of Indemnitee’s fees and expenses in bringing and pursuing the Enforcement Action
(including attorneys’ fees at any stage, including on appeal); provided, however, that the Company
shall not be required to provide such indemnity for such attorneys’ fees or expenses if a court of
competent jurisdiction determines that each of the material assertions made by Indemnitee in such
Enforcement Action was not made in good faith or was frivolous.

     4. Limitations on Indemnity; Mutual Acknowledgment

          (a) Limitation on Indemnity. No indemnity pursuant to this Agreement shall be
provided by the Company:

               (i) On account of any suit in which a final, unappealable judgment is rendered against
Indemnitee for an accounting of profits made from the purchase or sale by

-4-

 

Indemnitee of securities of the Company in violation of the provisions of Section 16(b) of the
Securities Exchange Act of 1934 and amendments thereto;

               (ii) For Damages that have been paid directly to Indemnitee by an insurance carrier under a
policy of officers’ and directors’ liability insurance maintained by the Company;

               (iii) On account of Indemnitee’s conduct which is finally adjudged to have been intentional
misconduct, a knowing violation of law or the RCW 23B.08.310 or any successor provision of the
Statute, or a transaction from which Indemnitee derived benefit in money, property or services to
which Indemnitee is not legally entitled; or

               (vi) If a final decision by a court having jurisdiction in the matter shall determine that
such indemnification is not lawful.

          (b) Mutual Acknowledgment. The Company and Indemnitee acknowledge that, in certain
instances, federal law or public policy may override applicable state law and prohibit the Company
from indemnifying Indemnitee under this Agreement or otherwise. For example, the Company and
Indemnitee acknowledge that the Securities and Exchange Commission (the “SEC”) has taken
the position that indemnification is not permissible for liabilities arising under certain federal
securities laws, and federal legislation prohibits indemnification for certain ERISA violations.
Furthermore, Indemnitee understands and acknowledges that the Company has undertaken or may be
required in the future to undertake with the SEC to submit the question of indemnification to a
court in certain circumstances for a determination of the Company’s right under public policy to
indemnify Indemnitee.

     5. Notification and Defense of Claim

          (a) Notification. Promptly after receipt by Indemnitee of notice of the commencement
(including a threatened assertion or commencement) of any Proceeding, Indemnitee will, if a claim
in respect thereof is to be made against the Company under this Agreement, notify the Company of
the commencement thereof; but the omission so to notify the Company will not relieve the Company
from any liability which it may have to Indemnitee under this Agreement unless and only to the
extent that such omission can be shown to have prejudiced the Company’s ability to defend the
Proceeding.

          (b) Defense of Claim. With respect to any such Proceeding as to which Indemnitee
notifies the Company of the commencement thereof:

               (i) The Company may participate therein at its own expense;

               (ii) The Company, jointly with any other indemnifying party similarly notified, may assume the
defense thereof, with counsel satisfactory to Indemnitee. After notice from the Company to
Indemnitee of its election so to assume the defense thereof, the Company shall not be liable to
Indemnitee under this Agreement for any legal or other expenses (other than reasonable costs of
investigation) subsequently incurred by Indemnitee in connection with the defense thereof unless
(A) the employment of counsel by Indemnitee has been authorized by the Company, (B)

-5-

 

Indemnitee shall have reasonably concluded that there may be a conflict of interest between
the Company and Indemnitee in the conduct of the defense of such action, or (C) the Company shall
not in fact have employed counsel to assume the defense of such action, in each of which cases the
fees and expenses of counsel shall be at the expense of the Company. The Company shall not be
entitled to assume the defense of any action, suit or proceeding brought by or on behalf of the
Company or as to which Indemnitee shall have made the conclusion provided for in (B) above;

               (iii) The Company shall not be liable to indemnify Indemnitee under this Agreement for any
amounts paid in settlement of any Proceeding effected without its written consent;

               (iv) The Company shall not settle any action or claim in any manner which would impose any
penalty or limitation on Indemnitee without Indemnitee’s written consent; and

               (v) Neither the Company nor Indemnitee will unreasonably withhold its, his or her consent to
any proposed settlement.

          (c) Notice to Insurers. If, at the time of the receipt of a notice of a claim
pursuant to Section 5(a) hereof, the Company has director and officer liability insurance in
effect, the Company shall give prompt notice of the commencement of such proceeding to the insurers
in accordance with the procedures set forth in the respective policies. The Company shall
thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of the
Indemnitee, all amounts payable as a result of such proceeding in accordance with the terms of such
policies.

     6. Severability. Nothing in this Agreement is intended to require or shall be
construed as requiring the Company to do or fail to do any act in violation of applicable law. The
Company’s inability, pursuant to court order, to perform its obligations under this Agreement shall
not constitute a breach of this Agreement. The provisions of this Agreement shall be severable, as
provided in this Section 6. If this Agreement or any portion hereof shall be invalidated on any
ground by any court of competent jurisdiction, then the Company shall nevertheless indemnify
Indemnitee to the full extent permitted by any applicable portion of this Agreement that shall not
have been invalidated, and the balance of this Agreement not so invalidated shall be enforceable in
accordance with its terms.

     7. No Employment Rights. Nothing contained in this Agreement is intended to create in
Indemnitee any right to continued employment.

     8. Officer and Director Liability Insurance. The Company shall, from time to time,
make the good faith determination whether or not it is practicable for the Company to obtain and
maintain a policy or policies of insurance with reputable insurance companies providing the
officers and directors of the Company with coverage for losses from wrongful acts, or to ensure the
Company’s performance of its indemnification obligations under this Agreement. Among other
considerations, the Company will weigh the costs of obtaining such insurance coverage against the
protection afforded by such coverage. In all policies of director and officer liability insurance,
Indemnitee shall be named as an insured in such a manner as to provide Indemnitee the same rights
and benefits as are accorded to the most favorably insured of the Company’s directors, if
Indemnitee

-6-

 

is a director; or of the Company’s officers, if Indemnitee is not a director of the Company
but is an officer. Notwithstanding the foregoing, the Company shall have no obligation to obtain
or maintain such insurance if the Company determines in good faith that such insurance is not
reasonably available, if the premium costs for such insurance are disproportionate to the amount of
coverage provided, if the coverage provided by such insurance is limited by exclusions so as to
provide an insufficient benefit, or if Indemnitee is covered by similar insurance maintained by a
parent or subsidiary of the Company.

     9. Partial Indemnification. If Indemnitee is entitled under any provision of this
Agreement to indemnification by the Company for some or a portion of the expenses, judgments, fines
or penalties actually or reasonably incurred in the investigation, defense, appeal or settlement of
any civil or criminal action, suit or proceeding, but not, however, for the total amount thereof,
the Company shall nevertheless indemnify Indemnitee for the portion of such expenses, judgments,
fines or penalties to which Indemnitee is entitled.

     10. Miscellaneous

          (a) Governing Law. This Agreement and all acts and transactions pursuant hereto and
the rights and obligations of the parties hereto shall be governed, construed and interpreted in
accordance with the laws of the State of Washington, without giving effect to principles of
conflict of law.

          (b) Entire Agreement, Enforcement of Rights. This Agreement sets forth the entire
agreement and understanding of the parties relating to the subject matter herein and merges all
prior discussions between them. No modification of or amendment to this Agreement, nor any waiver
of any rights under this Agreement, shall be effective unless in writing signed by the parties to
this Agreement. The failure by either party to enforce any rights under this Agreement shall not
be construed as a waiver of any rights of such party.

          (c) Construction. This Agreement is the result of negotiations between and has been
reviewed by each of the parties hereto and their respective counsel, if any; accordingly, this
Agreement shall be deemed to be the product of all of the parties hereto, and no ambiguity shall be
construed in favor of or against any one of the parties hereto.

          (d) Notices. Any notice, demand or request required or permitted to be given under
this Agreement shall be in writing and shall be deemed sufficient when delivered personally or sent
by telegram or forty-eight (48) hours after being deposited in the U.S. mail, as certified or
registered mail, with postage prepaid, and addressed to the party to be notified at such party’s
address as set forth below or as subsequently modified by written notice.

          (e) Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original and all of which together shall constitute one instrument.

          (f) Successors and Assigns. This Agreement shall be binding upon Indemnitee and upon
the Company, its successors and assigns, and shall inure to the benefit of Indemnitee, Indemnitee’s
heirs, personal representatives and assigns and to the benefit of the Company, its

-7-

 

successors and assigns. The Company shall require any successor to the Company (whether
direct or indirect by purchase, merger, consolidation or otherwise) to all or substantially all of
the business or assets of the Company, expressly to assume and agree to perform this Agreement in
the same manner and to the same extent that the Company would be required to perform if no such
succession had taken place.

          (g) Subrogation. In the event of payment under this Agreement, the Company shall be
subrogated to the extent of such payment to all of the rights of recovery of Indemnitee, who shall
execute all documents required and shall do all acts that may be necessary to secure such rights
and to enable the Company to effectively bring suit to enforce such rights.

[Signature page follows]

-8-

 

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement on and as of the day and
year first above written.

	 	 	 	 	 
	 	OMEROS CORPORATION

 	 
	 	By:  	 	 
	 	 	[Name] 	 
	 	 	[Title]	 
	 
	 	Address: 	 

AGREED TO AND ACCEPTED:

[Name]

 

(Signature)

Address:

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