Document:

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                                                                    EXHIBIT 10.3

                              AMENDMENT NUMBER FOUR

         This Amendment Number Four is dated as of September 20, 2001 and is to
the Credit Agreement among Hardinge Inc., the Bank's signatory thereto and The
Chase Manhattan Bank (National Association) (now The Chase Manhattan Bank) as
Agent, dated as of February 28, 1996 and amended by Amendment Number One dated
as of August 1, 1997, Amendment Number Two dated as of December 11, 2000 and
Amendment Number Three dated as of February 5, 2001 (as amended the
"Agreement"). Terms used but not otherwise defined herein shall have the
meanings ascribed thereto in the Agreement.

         The Borrower has determined to make certain adjustments to its
financial statements and to recognize a nonrecurring charge to its earnings for
the fiscal year ending December 31, 2001 in an amount not to exceed Thirty-Nine
Million Dollars ($39,000,000.00) (the "Earnings Charge").

         In order to further amend the Agreement, the parties agree as follows:

         1. The definition of "Earnings Before Interest, Taxes, Depreciation and
Amortization as set forth in Section 1.01 of the Agreement shall be amended
effective as of the date of this Amendment Number Four to read as follows:

                  "Earnings Before Interest, Taxes, Depreciation and
                  Amortization" means Consolidated Net Income prior to the
                  deduction of interest expense, prior to the deduction of
                  federal or foreign corporate income and corporate franchise
                  taxes, prior to the deduction of depreciation and amortization
                  and prior to the deduction of the Earnings Charge.
                  Notwithstanding anything to the contrary as set forth herein,
                  for the twelve (12) months following the Acquisition Date,
                  earnings before interest, taxes, depreciation and amortization
                  shall be calculated as if the Acquisition Date was January 1,
                  2000.

         2. The definition of "Margin" as set forth in Section 1.01 of the
Agreement shall be amended effective as of the date of this Amendment Number
Four to read as follows:

                  "Margin" means for each Variable Rate Loan zero (0) Basis
                  Points and for each Eurodollar Loan one hundred fifty (150)
                  Basis Points.

         3. The sale, lease or other disposition of assets related to the
Earnings Charge shall be exempt from the limitations of Section 7.05 of the
Agreement.

         4. Section 8.02 of the Agreement shall be amended to require the
minimum Consolidated Tangible New Worth for the fiscal year ending December 31,
2001 and for each fiscal year thereafter shall at all times be at least One
Hundred Thirty Million Dollars ($130,000,000.00).

<PAGE>

         5. Section 8.03 of the Agreement shall be amended to the effect that
Borrower shall maintain a ratio of Funded Debt to Earnings Before Interest,
Taxes, Depreciation and Amortization of not greater than 3.25 to 1 through June
29, 2002 and 3.0 to 1 from June 30, 2002 and thereafter, as measured as of the
last day of each fiscal quarter for the immediately preceding twelve (12)
months.

         6. Upon the execution of this Amendment Number Four, the Borrower shall
pay to the Agent an amendment fee in the amount of Five Thousand Three Hundred
Twenty-Five Dollars ($5,325.00).

         7. This Amendment Number Four may be executed in any number of
counterparts, all of which taken together shall constitute one and the same
instrument, and any parties hereto may execute this Amendment Number Four by
signing any such counterpart.

         8. Other than as set forth in this Amendment Number Four, the terms and
conditions of the Agreement shall remain in full force and effect.

         IN WITNESS WHEREOF, the parties have caused this Amendment Number Four
to be executed by their duly authorized officers as of the day and year first
above written.

                                      HARDINGE INC.

                                      By:  /s/ J.PATRICK ERVIN
                                           -------------------------------------
                                            J. Patrick Ervin, President
                                            and Chief Executive Officer

                                      AGENT:

                                      THE CHASE MANHATTAN BANK
                                      Successor by merger to The Chase Manhattan
                                      Bank (National Association)

                                      By:  /s/ CHRISTINE M. McLEOD
                                           -------------------------------------
                                            Christine M. McLeod, Vice President

<PAGE>

                                      BANKS:

                                      THE CHASE MANHATTAN BANK,
                                      Successor by merger to The
                                      Chase Manhattan Bank
                                      (National Association)

                                      By:  /s/ CHRISTINE M. McLEOD
                                           -------------------------------------
                                            Christine M. McLeod, Vice President

                                      THE CHASE MANHATTAN BANK
                                      f/k/a Chemical Bank

                                      By:  /s/ CHRISTINE M.  McLEOD
                                           -------------------------------------
                                             Christine M. McLeod, Vice President

                                      HSBC BANK USA
                                      f/k/a/ Marine Midland Bank

                                      By:  /s/ RONALD W. LESCH
                                           -------------------------------------
                                            Ronald W. Lesch, Vice President<Page>

                                                                    EXHIBIT 10.1

                         EXECUTIVE EMPLOYMENT AGREEMENT

     This Executive Employment Agreement (this "Agreement") is dated as of July
18, 2001 by and between Genzyme Transgenics Corporation ("GTC", and together
with its controlled affiliates and subsidiaries, the "Company"), a Massachusetts
corporation with its principal executive offices at 175 Crossing Boulevard, 4th
Floor, Suite 410, Framingham, MA 01702-9322; and Geoffrey F. Cox ("Executive").

                                    ARTICLE 1
                             EMPLOYMENT OF EXECUTIVE

     1.1   EMPLOYMENT. Subject to the terms and conditions of this Agreement,
the Company agrees to employ Executive in a full time capacity to serve as
Chairman of the Board and Chief Executive Officer of GTC and to perform such
specific duties that are normal and customary to such positions as may
reasonably be assigned to Executive from time to time by the Board of Directors
of GTC for the period commencing on July 17, 2001 (the "Effective Date") and
continuing until terminated as herein expressly provided. Executive hereby
accepts such employment for the term hereof.

     1.2   BOARD MEMBERSHIP. Executive has been elected as a member of the Board
of Directors of GTC with a term expiring at the annual meeting of stockholders
of GTC to be held in 2003. Subject to Executive's continued employment with the
Company, GTC will nominate Executive for re-election at such annual meeting of
stockholders.

     1.3   NO CONFLICTING COMMITMENTS. During the period of Executive's full
time employment with the Company, Executive will not undertake any commitments
which might materially impair Executive's performance of his duties as a full
time employee of the Company. Notwithstanding anything herein to the contrary
the Executive shall have the right to continue to serve on the Board of
Directors of Nabi, and may from time to time serve on such other boards of
directors, or boards of trustees, of both for-profit and not-for-profit
organizations, provided that such organizations are not directly competitive
with the business of GTC and such service does not materially impair Executive's
performance of his duties hereunder.

                                    ARTICLE 2
                                  COMPENSATION

     For all services to be rendered by Executive to the Company pursuant to
this Agreement, the Company shall pay to Executive the compensation and provide
for Executive the benefits set forth below:

     2.1   BASE SALARY. From the Effective Date through December 31, 2001, the
Company shall pay to Executive a base salary (the "Base Salary") of $31,666.67
per month (equivalent to an annual rate of $380,000), prorated during the period
Executive is employed hereunder and payable in substantially equal installments
in accordance with GTC payroll practice as in effect from time to time. With
respect to subsequent periods during the term of this Agreement, the
Compensation Committee of the Board of Directors of GTC (the "Committee) will
review Executive's base salary and other compensation from time to time and may
make adjustments to such base salary and determine such bonus based upon, among
other factors: (a) Executive's

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performance, (b) GTC's performance, (c) changes in costs of living, (d) changes
in Executive's responsibilities, and (e) the benefit to GTC of Executive's
efforts on its behalf; provided that Executive's base salary shall not be less
than $380,000 per year during the term of this Agreement.

     2.2   BONUSES. In addition to the Base Salary, Executive shall be eligible
to earn an annual cash incentive bonus of not less than forty percent (40%) of
Executive's then current Base Salary on an annualized basis, based on
Executive's achievement of certain individual and corporate objectives
established jointly by the Committee and Executive. Such cash bonus, if earned,
will be payable to Executive annually within one hundred twenty (120) days after
the end of the calendar year for which it is earned.

     2.3   STOCK OPTIONS. The Board of Directors of GTC will grant to Executive
options (the "Options") to purchase 285,000 shares of GTC's Common Stock, $0.01
par value per share, under GTC's 1993 Equity Incentive Plan (the "Plan"), at a
price per share equal to the opening price of GTC's Common Stock on the date
Executive commences employment with GTC. The Options shall be exercisable
immediately as to 20% of the shares and as to an additional 20% on each of the
next four anniversaries of the date Executive commences employment with the
Company. The Options shall have a term of ten years following the date of grant,
subject to early termination in the event of termination of Executive's
employment in accordance with this Agreement and the Plan, and such other terms
and conditions consistent with the form of stock option certificate most
recently approved by the Board or any authorized committee thereof for use under
the Plan or as the Board or any such committee may hereafter direct. The Options
granted to Executive shall be incentive stock options ("ISOs") under Section 422
of the federal Internal Revenue Code of 1986, as amended from time to time (the
"Code"), to the maximum extent permitted by law. In the event that the Options
granted to Executive are in an amount greater than the maximum permitted by such
Section 422 to obtain ISO treatment, the Company will work in cooperation with
Executive to designate a portion of the Options as ISOs and the remainder as
non-qualified stock options.

     2.4   PARTICIPATION IN FUTURE EQUITY INCENTIVE PLANS. Executive shall be
entitled to participate, to the extent and in the manner determined by GTC's
Board of Directors in its absolute discretion, in any stock option, stock
purchase or other equity incentive plan established by the Company from time to
time, it being the understanding of the Company and Executive that such
participation would be for the purpose of providing Executive additional
opportunities for equity participation in the Company.

     2.5   FRINGE BENEFITS. In addition to Executive's base salary and bonus,
Executive shall be entitled to participate in all employee benefit plans or
programs of GTC. GTC does not guarantee the adoption or continuance of any
particular employee benefit or stock plan or other program during the term of
this Agreement, and Executive's participation in any such plan or program shall
be subject to the provisions, rules and regulations applicable thereto.
Executive shall be entitled to four (4) weeks paid vacation each year in
accordance with applicable Company policy. Health and dental plans shall cover
Executive and his dependents as they do for other GTC executives. Such health
and dental plans comply with ERISA and COBRA to the extent applicable. Under
current health insurance policies, such COBRA rights will commence on
termination of the period over which severance payments are made under Section
3.2.

                                        2
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     2.6   RELOCATION AND OTHER EXPENSES.

           (a) The Company shall reimburse Executive for actual out-of-pocket
expenses incurred in connection with Executive's relocation from Texas to
Massachusetts, including but not limited to travel costs to and from Texas,
costs of shipping household goods and two automobiles, and real estate closing
costs on the sale of Executive's home in Texas and the purchase of a new home in
Massachusetts; provided that (A) such expenses are incurred not later than
twelve (12) months after Executive's commencement of employment with the Company
and (ii) the Company shall have no obligation to reimburse any such relocation
expenses to the extent they exceed, in the aggregate, $125,000. To the extent
Executive incurs federal or state tax liability in connection with his receipt
of such relocation reimbursement, the Company shall provide Executive with a
"gross-up" payment to cover such tax liability, but only to the extent that any
such gross-up payment and relocation expenses paid, in the aggregate, do not
exceed $125,000.

           (b) The Company shall reimburse Executive for up to an aggregate of
$30,000 of temporary living expenses, including, without limitation, (i)
reasonable temporary living costs for Executive within the twelve (12) month
period after the Effective Date, which costs may include hotel accommodations,
or a furnished apartment in Massachusetts and (ii) travel expenses incurred by
Executive for travel to and from his current home; provided that such costs are
incurred on or before twelve (12) after the Effective Date or such earlier date
as Executive purchases a home in Massachusetts. To the extent Executive incurs
federal or state tax liability in connection with his receipt of such temporary
living reimbursement, the Company shall provide Executive with a "gross-up"
payment to cover such tax liability, but only to the extent that any such
gross-up payment and relocation expenses paid, in the aggregate, do not exceed
$30,000.

           (c) The Company shall reimburse Executive for the foregoing expenses
and all ordinary and necessary business expenses incurred in the performance of
Executive's duties under this Agreement, provided that Executive accounts
properly for such expenses to the Company in accordance with the general
corporate policies of the Company and in accordance with the requirements of the
Internal Revenue Service regulations under the Code relating to substantiation
of expenses.

                                    ARTICLE 3
                                   TERMINATION

     3.1   TERMINATION. Executive's employment hereunder shall terminate upon
the occurrence of any of the following events:

           (a) Executive's employment hereunder shall terminate upon Executive's
death or inability, by reason of physical or mental impairment, to perform
substantially all of Executive's duties as contemplated herein for a continuous
period of 120 days or more;

           (b) The termination of Executive's employment hereunder for Cause by
the Board of Directors of GTC, at its option, to be exercised by delivery of
written notice to Executive;

                                        3
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           (c) The termination of Executive's employment hereunder by the Board
of Directors of GTC, at its option, without Cause, to be exercised by delivery
of written notice to Executive; or

           (d) The termination of Executive's employment hereunder by Executive
to be exercised by delivery of thirty (30) days prior written notice from
Executive to the Company, other than for Good Reason; or

           (e) The termination of Executive's employment hereunder by Executive,
at his option, if the Company breaches any material duty or obligation hereunder
and such breach is continuing and has not been waived by Executive (i) more than
30 days after written notice of such breach has been given by Executive to the
Board of Directors of GTC and (ii) as of the date notice of termination is
given.

     For purposes of this Agreement, "Cause" shall mean (i) Executive's breach
of any material duty or obligation hereunder after written notice of such breach
has been given to the Executive by the Board of Directors and such breach shall
have continued for thirty (30) days after receipt of such notice, or intentional
or grossly negligent conduct that is materially injurious to GTC, as reasonably
determined by GTC's Board of Directors, or (ii) willful failure to follow the
reasonable directions of GTC's Board of Directors after written notice of such
failure has been given to the Executive by the Board of Directors and such
failure shall have continued for thirty (30) days after receipt of such notice.

     3.2   PAYMENTS UPON TERMINATION. Notwithstanding any other provisions in
this Agreement to the contrary:

           (a) If Executive's employment with the Company or its successor in
interest terminates pursuant to Sections 3.1(a), 3.1(b), or 3.1(d): (i) all
payments and benefits provided to Executive under this Agreement shall cease as
of the date of termination of employment and Executive shall be entitled to
receive any unpaid Base Salary accrued through the date, plus credit for any
vacation earned but not taken and the amount, if any, and any bonus awarded for
the past fiscal year which has not yet been paid to Executive; and (ii) all
further vesting on all stock options to purchase Common Stock of GTC then held
by Executive on that date shall immediately cease as of the date of termination
of employment and thereafter such stock options shall be exercisable by
Executive in accordance with their respective terms.

           (b) If Executive's employment with the Company or its successor in
interest terminates pursuant to Section 3.1(c) or 3.1(e), Executive shall be
entitled to the benefits provided in Section 4.2 hereof.

                                    ARTICLE 4
                     TERMINATION FOLLOWING CHANGE IN CONTROL

     4.1   TERMINATION OF EMPLOYMENT FOLLOWING CHANGE IN CONTROL. If a Change
in Control of the Company shall have occurred, Executive shall be entitled to
the benefits provided in Section 4.2 hereof upon the subsequent termination of
Executive's employment within twelve (12) months after the effective date of
such Change in Control, unless such termination is (a) because of Executive's
death or Retirement, (b) by the Company for Cause or (c) by Executive other than
for Good Reason. For purposes of this Agreement:

                                        4
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           (a) "Change in Control of the Company" shall mean:

               (i)   the acquisition (A) by any "person" (as such term is
defined in Section 3(a)(9) of the Securities Exchange Act of 1934) or (B) by
Genzyme Corporation, from any party of an amount of GTC's Common Stock so that
it holds or controls 50% or more of GTC's Common Stock;

               (ii)  a merger or similar combination after which 49% or more of
the voting stock of the surviving corporation is held by persons who were not
stockholders of GTC immediately prior to such merger or combination;

               (iii) an acquisition, merger or similar combination or a
divestiture of a substantial portion of the Company's business after which
Executive's role is not substantially the same as such role prior to the
transaction;

               (iv)  the election by the stockholders of GTC of 20% or more of
the directors of GTC other than pursuant to nomination by GTC's management; or

               (v)   the sale by the Company of all or substantially all of its
assets or business.

           (b) "Good Reason" shall mean termination by Executive after a Change
in Control upon:

               (i)   the assignment of any duties to Executive inconsistent with
Executive's position, duties, responsibilities and status with the Company
immediately prior to the Change in Control, or a change in Executive's reporting
responsibilities, titles or offices as in effect immediately prior to a Change
in Control, or any removal of Executive from or any failure to re-elect
Executive to any of such positions except in connection with the termination of
Executive's employment for Cause or Retirement or as a result of Executive's
death or by Executive other than for Good Reason, each without Executive's
express written consent;

               (ii)  a reduction by the Company in Executive's Base Salary as in
effect on the date hereof or as the same may be increased from time to time;

               (iii) the Company's requiring Executive to be based anywhere
other than within sixty (60) miles of Executive's office location immediately
prior to the Change in Control, except for required travel on the Company's
business to an extent substantially consistent with Executive's business travel
obligations in the twelve months immediately prior to the Change in Control
without Executive's express written consent; or

               (iv)  the failure by the Company to obtain the assumption of the
agreement to perform this Agreement by any successor as contemplated in Section
6.4 hereof.

           (c) "Retirement" shall mean termination of Executive's employment in
accordance with GTC's retirement policy, including early retirement, generally
applicable to its salaried employees.

                                        5
<Page>

     4.2   PAYMENTS UPON TERMINATION WITHOUT CAUSE, FOR GOOD REASON, FOLLOWING
CHANGE IN CONTROL. In addition to, and not in limitation of, the provisions of
Article 3, if, within twelve (12) months after a Change in Control of the
Company, Executive's employment is terminated (a) by the Company or its
successor in interest other than for Cause or Retirement or (b) by Executive for
Good Reason, then Executive shall be entitled to the benefits provided below:

           (a) BACK SALARY PAYMENT. The Company shall pay Executive any unpaid
Base Salary accrued through the date of termination at the rate in effect at the
time notice of termination is given, plus credit for any vacation earned but not
taken and the amount, if any, and any bonus awarded for the past fiscal year
which has not yet been paid to Executive;

           (b) SEVERANCE PAYMENT. The Company shall pay Executive an aggregate
severance payment equal to (i) twenty-four months of Base Salary in effect on
the date of termination and (ii) an amount equal to Executive's maximum
incentive bonus that would next be payable to him and would otherwise be due to
Executive if such termination had not occurred and the maximum amount of such
bonus had been fully earned, pro rated on the basis of the number of days that
have elapsed between the beginning of the bonus period in which such termination
occurs and the date of termination (the "Severance Amount"), which Severance
Amount shall be payable in substantially equal monthly installments over a
24-month period following the date of termination;

           (c) CONTINUATION OF BENEFITS. The Company shall maintain in full
force and effect, for Executive's continued benefit until the earlier of (a) the
end of the 24th calendar month following the date of termination of employment
or (b) Executive's commencement of full time employment with a new employer, all
life insurance, medical, health and accident insurance, and disability plans,
programs or arrangements in which Executive was entitled to participate
immediately prior to the date of termination, provided that Executive's
continued participation is possible under the general terms and provisions of
such plans and programs. In the event that Executive's participation in any such
plan or program is barred, the Company shall arrange to provide Executive with
benefits substantially similar to those which Executive was entitled to receive
under such plans and programs at its expense; and

           (d) ACCELERATED VESTING OF STOCK OPTIONS. Any stock options to
purchase Common Stock of GTC then held by Executive on the date of termination
which are then subject to vesting shall, notwithstanding any contrary provision
in this Agreement or the Plan pursuant to which such options had been granted,
become fully vested and exercisable on the date of termination, and such stock
options shall remain exercisable by Executive for a period of twenty-four (24)
months after the date of termination. Executive acknowledges that any incentive
stock options exercised more than ninety days after the date of termination
shall no longer qualify as incentive stock options under the Code.

     4.3   LIMITATION ON BENEFIT PAYMENTS. The benefits payable under this
Agreement are subject to the limitation that, when added to the aggregate
present value of any other payments in the nature of compensation to Executive
which are contingent on a Change of Control within the meaning of Section
280G(b)(2)(A)(i) of the Code, they may not exceed 2.99 times the "base amount"
as defined in Section 280G(b)(3)(a) of the Code.

                                        6
<Page>

                                    ARTICLE 5
                  CONFIDENTIAL INFORMATION AND NON-COMPETITION

     As a condition to the Company's obligations hereunder, Executive will
execute a confidentiality and non-competition agreement pertaining to the
intellectual property and confidential information of the Company and the
Company's standard form of non-competition provision for executive officers and
key employees. The obligations of Executive under this Article 5 and the
agreements referenced in this paragraph shall survive termination of this
Agreement for any reason.

                                   ARTICLE 6
                                 MISCELLANEOUS

     6.1   COUNTERPARTS. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, and all of which
together shall be deemed to be one and the same instrument.

     6.2   BINDING EFFECT. This Agreement shall inure to the benefit of and be
binding upon the parties hereto and their respective lawful successors and
assigns and upon Executive's heirs and personal representatives.

     6.3   ASSIGNMENT. This Agreement may not be assigned, in whole or in part,
by any party without the prior written consent of the other party, except that
GTC may, without the consent of Executive, assign its rights and obligations
under this Agreement to any corporation, firm or other business entity with or
into which GTC may merge or consolidate, or to which GTC may sell or transfer
all or substantially all of its assets, or of which 50% or more of the equity
investment and of the voting control is owned, directly or indirectly, by, or is
under common ownership with, GTC. After any such assignment by GTC, GTC shall be
discharged from all further liability hereunder and such assignee shall have all
the rights and obligations of GTC under this Agreement.

     6.4   ENTIRE AGREEMENT. This Agreement is the entire agreement of the
parties with respect to the subject matter hereof and supersedes any prior
agreement or understanding relating to Executive's employment with or
compensation by the Company including, but not limited to, the Executive
Employment Agreement between Executive and the Company entered into effective as
of July 17, 2001.

     6.5   NOTICES. All notices, requests, demands and other communications to
be given pursuant to this Agreement shall be in writing and shall be deemed to
have been duly given if delivered by hand or mailed by registered or certified
mail, return receipt requested, postage prepaid, as follows:

           If to the Company, to:

           Genzyme Transgenics Corporation
           175 Crossing Boulevard
           4th Floor, Suite 410
           Framingham, MA  01702-9322
           Attention:  Chief Financial Officer

                                        7
<Page>

                    on or before October 25, 2001, with a copy to:

           Nathaniel S. Gardiner, Esq.
           Palmer & Dodge LLP
           One Beacon Street
           Boston, Massachusetts 02108

                    after October 25, 2001, with a copy to:

           Nathaniel S. Gardiner, Esq.
           Palmer & Dodge LLP
           111 Huntington Avenue at Prudential Center
           Boston, Massachusetts 02199-7613

           If to Executive, to:

           Geoffrey F. Cox at his then current address on the payroll records of
           the Company;

or such other address as either party hereto shall have designated by notice in
writing to the other party.

     6.6   AMENDMENTS. This Agreement may be amended, supplemented or otherwise
modified at any time, but only by an instrument in writing signed by the parties
hereto.

     6.7   GOVERNING LAW. This Agreement and the legal relations among the
parties hereto shall be governed by and construed in accordance with the laws of
the Commonwealth of Massachusetts, without regard to its conflict of law
provisions.

     6.8   SEVERABILITY. In case any provision hereof shall, for any reason, be
held to be invalid or unenforeceable in any respect, such invalidity or
unenforceability shall not affect any other provision hereof, and this Agreement
shall be construed as if such invalid or unenforceable provision had not been
included herein. If any provision hereof shall, for any reason, be held by a
court to be excessively broad as to duration, geographical scope, activity or
subject matter, it shall be construed by limiting and reducing it to make it
enforceable to the extent compatible with applicable law as then in effect.

     6.9   SURVIVAL. Articles 5 and 6 shall survive the termination of this
Agreement for the periods of time indicated therein or indefinitely if no period
of time is indicated.

                      [This space left blank intentionally]

                                        8
<Page>

     IN WITNESS WHEREOF, the undersigned have duly executed and delivered this
Agreement as of the date first above written.

                          EXECUTIVE:

                          /s/ Geoffrey F. Cox
                          ---------------------------------------------------
                          Geoffrey F. Cox

                          COMPANY:

                          GENZYME TRANSGENICS CORPORATION

                          By:/s/ John B. Green
                             -----------------------------------------------
                             John B. Green
                             Vice President

                                        9

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