Document:

Exhibit
10.1

 

FIRST AMENDMENT

 

to

 

the
Collaboration, License and Supply Agreement, dated July 6, 2004

 

by and
between

 

Acusphere
Inc. (“Acusphere”)

 

and

 

Nycomed
Danmark ApS (“Nycomed”)

 

 

This First Amendment (the “First Amendment”),
effective as of October 19, 2005, is entered into by and between Acusphere and
Nycomed (the “Parties”).

 

WHEREAS,
the Parties entered into a Collaboration, License and Supply Agreement, dated
July 6, 2004 (“the Agreement”);
and

 

WHEREAS,
the Parties have agreed to make a prepayment to Acusphere of a certain amount,
such amount to be deducted from Nycomed’s next milestone payment under the
Agreement; and

 

WHEREAS,
the agreed prepayment amount shall be used by Acusphere to accelerate the
trademark activities related to the Product (as defined in the Agreement);

 

NOW THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the
Parties agree as follows:

 

 

1.                                       In order to
accelerate the trademark activities related to the Product (as defined in the
Agreement), the milestone payment set forth in Section 4.03(a) shall be reduced
by $150,000, and Nycomed shall pay to Acusphere, as licensing fees, a milestone
payment equal to $150,000 on October 24, 2005, such milestone payment to be deemed
a milestone payment paid under Section 4.03 of the Agreement for all purposes
of the Agreement.

 

2.                                       Except as
otherwise set forth herein, all of the terms and conditions of the Agreement
shall remain in full force and effect between the Parties.

 

 

IN WITNESS WHEREOF, the Parties hereto have
caused this First Amendment to be executed in duplicate by their duly
authorized officers as of the date first above stated.

 

 

	
  ACUSPHERE, INC.,  

  	
   

  	
  NYCOMED DANMARK ApS  

  
	
  a Delaware corporation

  	
   

  	
  a Danish corporation 

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  By:

  	
   

  	
  /s/          Sherri
  C. Oberg

  	
   

  	
  By:

  	
  /s/
  Håkan Björklund

  
	
  Name:

  	
  Sherri C. Oberg

  	
   

  	
  Name:

  	
  Håkan Björklund

  
	
  Title:

  	
  President and Chief
  Executive Officer

  	
   

  	
  Title:

  	
  Chief Executive Officer,
  Nycomed Group<PAGE>

                                                                    EXHIBIT 10.1

HSBC Logo

Ref:  CMB GP3 - DIV M(CARM SN 050114)

CONFIDENTIAL

Concord Camera HK Ltd.
14/F Concord Technology Centre
98 Texaco Road
Tsuen Wan
NEW TERRITORIES
                                                                21 January 2005
Attention:  Mr. Harlan Press / Mr. Paul Wong

Dear Sirs:

BANKING FACILITIES
A/C NO.500-166012-001

With reference to our recent discussion, we are pleased to advise that we have
reviewed your banking facilities and offer a renewal within the following
revised limits subject to review at any time and, in any event by 31 March 2005,
and also subject to our overriding right of suspension, withdrawal and repayment
on demand, including the right to call for cash cover on demand for prospective
and continent liabilities.

<TABLE>
<CAPTION>
                                                                 New                         Previously
                                                                 ---                         ----------
<S>                                                            <C>                         <C>
Import Facilities                                                HKD107,500,000.-*           HKD187,500,000.-*
-----------------

Documentary Credits to your suppliers
and Import Loan Facilities in either
HK Dollars or Foreign Currency for
up to 120 days, less any Usance/credit
periods granted by your suppliers

within which                                                     (HKD107,500,000.-)*         (HKD187,500,000.-)*

Goods under your control and/or Trust Receipts

Packing Credit                                                               *                           *
--------------

Up to 70% of valid export Documentary Credits In your favor deposited with us
for up to 75 days Before shipment date
</TABLE>

*    Within the above Import (TR) facilities of HKD107,500,000.-
     ((HKD107,500,000.-), a sub-limit of HKD20,000,000.- may be switchable to
     Packing Credit facility.

We may, at our sole and absolute discretion, refuse to allow drawings under the
facilities if the transaction in question does not meet our operational
requirements in respect of these facilities.

<PAGE>

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                                       -2-
Concord Camera HK Ltd                                           21 January 2005
-------------------------------------------------------------------------------

Interest on the import loans and packing credit loans will continue to be
charged on daily basis as follows and payable monthly in arrears to the debit of
your current account:-

HK Dollar : 1.75% over HIBOR on import loans and packing credit loans
respectively Foreign currency : 1.75% over SIBOR or 1% below our standard Trade
Finance Rates as published by us

Interest at the above-mentioned rates over HIBOR (Hong Kong Interbank Money
Market Offer Rate) and SIBOR (Singapore Interbank Money Market Offer Rate) are
subject to fluctuation at our discretion and payable at the end of each interest
period to the debit of your current account.

                                                New              Previously
                                                ---              ----------

Revolving Loan                                  NIL              EUR10,000,000.-
--------------

Guarantees                                      EUR380,000.-     EUR380,000.-
----------

For issuance of a EUR380,000.- open-ended
Guarantee in favour of Rabobank

Commission on the above guarantee facility will be charged at 1.25% per annum on
the amount of guarantee issued-renewed, which is subject to change at the Bank's
discretion.

Please note the full amount of the commission will be payable in advance on a
yearly basis to the debit of your current account with us notwithstanding
subsequent return/cancellation of the guarantee issued/renewed prior to expiry.

The commission rate specified above will apply to the guarantee issued/renewed
on your behalf notwithstanding that a different rate may have been specified in
any Counter-Indemnity issued by you in our favour prior to the date of this
letter in respect of such guarantee and it is agreed that the rate specified
above will apply with effect from the issue/renewal of such guarantee or
otherwise as indicated above. All other terms of any such Counter-Indemnity
remain unchanged.

                                        New                  Previously

Foreign Exchange Limit                  HKD15,000,000.-      HKD15,000,000.-
----------------------

For booking foreign exchange
contracts up to this Limit in
aggregate, with individual
contracts for Periods of up to
a maximum of three months forward.

<PAGE>

HSBC Logo

                                       -3-
Concord Camera HK Ltd                                           21 January 2005
-------------------------------------------------------------------------------

Contracts may only be entered into to cover trade related exchange exposure
incurred in the normal course of business.

Foreign Exchange facility remains subject to our overriding right to call for
cash cover on demand if in the Bank's view a negative foreign exchange position
requires such cover. Further, the Bank may, after having discussed the position
with yourselves, close out any or all of your outstanding forward foreign
exchange contracts and demand settlement of the balance due.

Foreign exchange contracts will be governed by the conditions appearing on the
reverse of the standard contract form. These contract forms should be checked
upon receipt and the copy signed and returned to the Bank.

Default Interest

Please note that interest will be payable on sums which are overdue, drawings
which are in excess of agreed limits and amounts demanded and not paid, at the
maximum rate stipulated in the Bank's Tariff which is accessible at
http://www/hsbc.com.hk/hk/business/tool/pdf/c_tariff.pdf. The Bank will provide
you with a hard copy of the Tariff at your request. Interest at the applicable
rate will be payable monthly in arrears to the debit of your current account.

Accrual of Interest and Other Sums

Please note that interest and other sums expressed to be chargeable or payable
on a periodic basis will nonetheless accrue from day to day and amounts so
accrued may be demanded at any time.

Security

As security, we shall continue to hold:-

1)   A Letter of Awareness dated 24 August 1998 from Concord Camera Corp
     together with a Certificate of Assistant Secretary dated 3 September 1998.

2)   A Letter of Undertaking from your company together with the minutes of
     meeting both dated 24 August 1998 undertaking:

     (a)  to direct to us bills business of not less than HKD100,000,000.- on an
          annual basis;

     (b)  to maintain the tangible net worth of your company above
          HKD110,000,000.- at all times;

     (c)  to maintain the net gearing ratio (after netting cash balance) of your
          company below 45% at all times;

     (d)  not to declare dividends of more than 50% of recurrent net profit in
          any financial year.

3)   A Letter of Undertaking dated 20 July 1999 from your company together with
     the minutes of meeting dated 19 July 1999 undertaking to direct to us all
     I/E bills business of your company.
<PAGE>
HSBC Logo

                                       -4-
Concord Camera HK Ltd                                           21 January 2005
-------------------------------------------------------------------------------

4)   A Corporate Guarantee for USD4,200,000.- from Concord Camera Corp with
     minutes of meeting both dated 19 August 1999 and a copy of legal opinion
     dated 9 August 1999 from Holland & Knight LLP.

5)   A Corporate Guarantee for USD4,000,000.- from Concord Camera Crop. With
     minutes of meeting and Certification all dated 11 November 1999.

6)   A Corporate Guarantee for USD5,500,000.- from Concord Camera Corp with
     minutes of meeting and Certification all dated 18 October 2000.

7)   A Letter of Undertaking from your company together with the minutes of
     meeting both dated 28 August 2000 undertaking to maintain a tangible Net
     Worth of your company at not less than HKD25-,000,000. Tangible Net Worth
     is defined as the aggregate of Paid Up Capital, Retained Earnings and
     Reserves.

8)   Registered Assignment of DC Proceeds form dated 4 May 2001 together with
     the minutes of meeting dated 28 August 2000 executed by your company.

9)   An "all monies" debenture over all the assets and undertakings of your
     company with minutes of meeting both dated 10 June 2004.

10)  A Corporate Guarantee for USD10,300,000.- from Concord Camera Corp with
     minutes of meeting and Certification all dated 31 January 2004.

11)  A Corporate Guarantee for EUR380,000.- dated 16 December 2003 from Concord
     Camera Corp with minutes of meeting and Certification both dated 31 January
     2004.

12)  A Corporate Guarantee for EUR10,000,000.- dated 3 June 2004 from Concord
     Camera Corp with minutes of meeting dated 27 April 2004 and Certification
     dated 3 June 2004.

As additional security for the above revised facilities, please let us have the
following:-

(1)  A Letter of Undertaking from Concord Camera Corp together with (i) a
     certified copy of a Board Resolution in substantially the form as that
     enclosed with this facility letter; and (ii) a legal opinion from qualified
     solicitor in USA, undertaking to recapitalize Concord Camera HK Ltd by
     converting HKD85,000,000.- advance to Concord Camera HK Ltd into equity.

(2)  A Subordination Agreement from Concord Camera Corp in respect of advances
     of HKD155,000,000.- to Concord Camera HK Ltd together with (i) certified
     copy of a Board Resolution in substantially the form as that enclosed with
     this facility letter; and (ii) a legal opinion from qualified solicitor in
     USA. A copy of Subordination Agreement is attached for execution of Concord
     Camera Corp.
<PAGE>

HSBC Logo

                                       -5-
Concord Camera HK Ltd                                           21 January 2005
-------------------------------------------------------------------------------

As a special condition, Concord Camera HK Ltd is required to submit to our Bank
on a quarterly basis your aged debtors' listing and inventory summary.

A review fee of HKD25,000.- will be charged to the debit of your current account
upon your acceptance of this facility letter.

Please arrange for the authorized signatories of your company, in accordance
with the terms of the mandate given to the Bank, to sign and return to us the
duplicate copy of this letter to signify your confirmation as to the correctness
of the security held, and your continued understanding and acceptance of the
terms and conditions under which these facilities are granted.

Please note that Section 83 of the Banking Ordinance has imposed on us as a bank
certain limitations on advances to persons related to our directors or
employees. In acknowledging this Facility Letter you should advise us whether
you are in any way related to any of our directors or employees within the
meaning of Section 83 and in the absence of such advice we will assume that you
are not so related. We would also ask, should you become so related subsequent
to acknowledging this Facility Letter, that you immediately advise us in
writing.

These facilities will remain open for acceptance until the close of business on
8 February 2005 and if not accepted by that date will be deemed to have lapsed.

We are pleased to be of continued assistance.

Yours faithfully

NELSON HO
Relationship Manager

ac

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