Document:

License Agreement

 Exhibit 10.44 
 Confidential Materials omitted and filed separately with the 
 Securities and Exchange Commission. Asterisks
denote omissions. 
 LICENSE AGREEMENT 
 THIS AGREEMENT, dated as of April 7th, 2003 (the “Effective Date”), is between
Infinity Pharmaceuticals, Inc., a Delaware corporation, having a business address of 780 Memorial Drive, Cambridge, MA 02139, and Discovery Partners International, Inc., a Delaware corporation, having a business address of 9640 Towne Centre Drive,
San Diego, California 92121. 
 WHEREAS, DPI owns and controls certain intellectual property related to radio frequency tagging;

 WHEREAS, Infinity uses and seeks to continue to use radio frequency technology in connection with its chemical compound synthesis
and drug discovery programs; and 
 WHEREAS, DPI and Infinity believe they would benefit by entering into an agreement whereby DPI
grants Infinity a license under certain DPI Patent Rights. 
 NOW THEREFORE, in consideration of the premises and the mutual covenants
and agreements set forth herein, the Parties hereby agree as follows: 
 ARTICLE 1 
 INTERPRETATION 
 1.1 Definitions

 As used in this Agreement, the following terms have the following meanings: 
 1.1.1 “Affiliate” means, with respect to any Person, any other Person that, directly or indirectly through one or more other
intermediaries, Controls, is Controlled by, or is under common Control with, the first mentioned Person. 
 1.1.2
“Agreement” means this Agreement and all schedules attached to this Agreement, in each case as they may be amended or supplemented from time to time, and the expressions “hereof, “herein”, “hereto”,
“hereunder”, “hereby” and similar expressions refer to this agreement; and unless otherwise indicated, references to Articles, Sections and Schedules are to Articles, Sections and Schedules in this Agreement. 
 1.1.3 “Confidential Information” means any and all information of a Party or any of its Affiliates which is maintained as confidential
by the Party or its Affiliates, including: 
 a. information relating to the business or affairs of the Party or its Affiliates, including
internal personnel and financial information, purchasing and internal cost information, forecasts and forecast assumptions and volumes, future plans and potential strategies, financing, acquisition, production, development and distribution
agreements and budgets and investment opportunities and structures, product information, marketing and development plans and agreements, price and cost data, price and fee amounts, pricing and billing policies, quoting procedures, marketing
techniques and methods of obtaining business, 

 
contracts and their contents, business plans and business deals with vendors and customers, vendor names and other vendor information, customer links and
names and data provided by customers and the type, quality and specifications of products and services purchased, leased, licensed or received by customers; 
 b. information relating to Intellectual Property Rights (including patents, copyrights, trademarks, topographies, know-how and trade secrets), including developments, inventions, designs, works of authorship,
improvements and ideas, whether or not patentable or copyrightable, including the nature of the intellectual property, production, technical data, test data and test results, the status and details of research and development of products and
services, and information regarding acquiring, protecting, enforcing and licensing proprietary rights; 
 c. documents, working papers,
notes, observations, summaries, explanations, or other material prepared by any Person and derived from the Confidential Information, but only to the extent such material directly includes Confidential Information of the Party and not information of
the other Person; 
 d. the existence, and the terms and conditions, of this Agreement; 
 e. information marked or otherwise identified as confidential, restricted, secret or proprietary; and 
 f. information acquired by inspection or oral disclosure if such information has been identified as confidential at the time of disclosure or inspection
and said information is reduced to writing within 60 days after the disclosure or inspection. 
 1.1.4 “Control” means the
possession of the power to direct the management and policies of a Person whether through ownership of voting securities, by contract or otherwise, and the words “Controls”, “Controlled by” and similar words have corresponding
meanings; provided that the ownership of 50% or more of the equity or voting securities of a corporation shall be deemed to constitute Control of the corporation. 
 1.1.5 “DPI” means Discovery Partners International, Inc. and, where the context requires, its Affiliates. 
 1.1.6 “DPI Patent Rights” means rights held by DPI under any and all of the following patents and patent applications, as well as any continuing application (a continuation-in-part application shall
only be included to the extent its claims were contained in the prior applications) that claims priority from a pending application listed herein, and any patent that issues from a pending or continuing application, any corresponding foreign
application or patent, and any re-examined or reissued patent, and any future DPI patent or patent application which has claims directed to or which covers the Licensed Products: 
  

			
	 Issued Patents
	  	 Currently Pending Applications

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	[**]	  	[**]
		
	[**]	  	[**]
		
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 1.1.7 “Effective Date” shall be as defined in the preamble hereto. 
 1.1.8 “Expiration Date” means the expiration date of the last to expire of the patents and patent applications within the DPI Patent
Rights. 
 1.1.9 “Field” means the use of radio frequency tagging for the development and/or production (synthesis) of
organic chemical compounds in connection with Infinity’s chemical compound synthesis and drug discovery programs. 
 1.1.10
“Infinity” means Infinity Pharmaceuticals, Inc., a Delaware corporation, and where the context requires, its Affiliates 
 1.1.11 “Intellectual Property Rights” means any right provided to a Party under: (a) patent law (including the DPI Patent Rights in the case of DPI, and Improvements and right to file patents); (b) copyright law;
(c) trademark law; (d) design patent or industrial design law; (e) any other statutory provision or common law principle that may provide a right in either (i) ideas, formulae, algorithms, concepts, inventions, know-how or
Improvements, or (ii) the expression of such ideas, formulae, algorithms, concepts, inventions, know-how or Improvements; and (f) any and all applications, registrations, licenses, sub-licenses, franchises, agreements or any other evidence
of a right in any of the foregoing. 
 1.1.12 “License” means the license granted by DPI to Infinity pursuant to this
Agreement. 
 1.1.13 “Licensed Products” means any organic chemical compound developed and/or synthesized by using a means
or mechanism or any other process that infringes upon at least one valid claim in an issued patent or a claim in a pending application within the DPI Patent Rights. 
 1.1.14 “Losses” shall be as defined in Section 7.1. 
 1.1.15 “Notice of
Default” shall be as defined in Sections 8.2 and 8.3. 
 1.1.16 “Party” means a party to this Agreement.

 1.1.17 “Person” means any individual, partnership, limited partnership, syndicate, sole proprietorship, company or
corporation with or without share capital, limited liability company, joint stock company, unincorporated association, trust, trustee, executor, administrator or other legal personal representative, regulatory body or agency, government or
governmental agency, authority or entity, howsoever designated or constituted. 
  

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 1.1.18 “Termination Date” means the first to occur of (i) the Expiration Date and
(ii) an earlier date on which a Party terminates this Agreement pursuant to the terms hereof. 
 1.2 Construction 
 Any reference to any federal, state, local or foreign statute or law shall be deemed also to refer to all rules and regulations promulgated thereunder,
unless the context requires otherwise. The word “including” shall mean “including without limitation”. All pronouns and any variations thereof refer to the masculine, feminine or neuter, singular or plural, as the context may
require. All terms defined in this Agreement in their singular or plural forms have correlative meanings when used herein in their plural or singular forms, respectively. All references herein to dollar amounts shall mean United States Dollars. The
inclusion of headings in this Agreement is for convenience of reference only and shall not affect the construction or interpretation of any provision. 
 ARTICLE 2 
 LICENSE AND ROYALTIES 
 2.1 License 
 Subject to the terms and
conditions of this Agreement, DPI hereby grants to Infinity a non-exclusive, worldwide license until the Termination Date under the DPI Patent Rights to use the Licensed Products solely in the Field. Upon royalty payments totaling one hundred
thousand dollars ($100,000) from Infinity to DPI, the granted License shall convert to a fully paid-up, perpetual world-wide license. 
 2.2
No Right to Sublicense 
 2.2.1 Infinity shall not have the right to sublicense any or all of the DPI Patent Rights licensed to
Infinity hereunder. 
 ARTICLE 3 
 INTELLECTUAL PROPERTY; COMPLIANCE WITH LAW 
 3.1 Trademarks 
 No right is granted to a Party to use any trademarks of the other Party (including its Affiliates) except as expressly permitted in this Agreement.

 3.2 Non-Alteration 
 Infinity acknowledges and agrees that, except as otherwise specifically provided herein, DPI retains all of its right, title and interest in the DPI Intellectual Property Rights: and DPI acknowledges and agrees that, except as otherwise
specifically provided herein, Infinity retains all of its rights, title and interest in the Infinity Intellectual Property Rights. 
  

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 3.3 Validity and Enforceability 
 Infinity shall not at any time during or after the term of this Agreement assert any claim or interest in, or intentionally do anything that may adversely
affect the validity or enforceability of, the DPI Patent Rights. 
 3.4 Release 
 DPI hereby releases Infinity and its Affiliates, officers, directors, agents, and employees from all claims, demands, and rights of action that DPI may
have on account of any alleged infringement of any DPI Patent Rights that might have occurred prior to the Effective Date. This Agreement is intended to and shall settle all disputes or claims, or possible disputes or claims, between the Parties
with respect to DPI Patent Rights, whether known or unknown, that have been or could have been asserted based upon the facts and circumstances disclosed by Infinity to DPI. 
 ARTICLE 4 
 PAYMENTS 
 4.1 Payment of Royalty 
 Infinity
shall make the following payments to DPI: 
 a. $[**] upon execution of this Agreement; and, 
 b. $[**] on or before December 15, 2003. 
 4.2 DPI Preferred Customer Discount to Infinity 
 During 2003, DPI shall offer Infinity a discount that can be applied
towards any products and/or services ordered by Infinity from DPI. The maximum total of the discount shall not exceed $[**]. The discount shall be applied at a rate of [**]% from DPI’s ordinarily applied rate or fees and Infinity shall not be
entitled to a discount amount in excess of the cash payments made then to date in Section 4.1, however, Infinity has the option to make the payments described in 4.1 (b) earlier than otherwise required in order to receive the benefit of
the discount. 
 ARTICLE 5 
 CONFIDENTIAL INFORMATION 
 5.1 Obligation to Keep Confidential 
 Except as set forth in Section 5.5, each Party shall keep, and shall cause its Affiliates, directors, officers, employees, representatives, agents
and financiers to keep, the Confidential Information of the other Party confidential, and shall not disclose or permit to be disclosed, the Confidential Information of the other Party to any Person except to such of its Affiliates, directors,
officers, employees, representatives, agents and financiers with a need to know in the normal course of their work. Each Party agrees to take reasonable steps (including those steps that it takes to protect its own information, data or other
tangible or intangible property that it regards as confidential) to ensure the confidentiality of the Confidential Information of the other Party. 
  

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 5.2 Use of Confidential Information 
 Each Party shall not, nor shall it permit any Person to whom disclosure is permitted, to use, sell, rent, lease, transfer, encumber, pledge, reproduce,
publish, transmit, translate, modify, disassemble or otherwise use any Confidential Information of the other Party except in relation to the performance of its obligations pursuant to this Agreement. 
 5.3 Unauthorized Disclosure 
 Each
Party shall notify, in writing, the other Party of the existence of any unauthorized possession or use of the Confidential Information of the other Party promptly after discovery of any unauthorized disclosure, possession or use of such Confidential
Information by any Person, and of the circumstances surrounding such unauthorized disclosure, possession or use. Each Party shall cooperate with the other Party, at such other Party’s expense (unless the first Party was at fault for the
unauthorized disclosure, in which case at such first Party’s expense), to stop such unauthorized disclosure, possession or use. 
 5.4
Return of Confidential Information 
 Upon Termination, if requested, each Party shall return to the other Party all documents and
other material containing Confidential Information of the other Party. 
 5.5 Permitted Disclosure 
 The provisions of Sections 5.1 through 5.4 shall not apply to information that: 
 5.5.1 is in the public domain other than as a consequence of a breach of the obligations contained in this Agreement to maintain the confidentiality of
Confidential Information; 
 5.5.2 is known by a Party prior to the disclosure of the information to that Party by the other Party;

 5.5.3 is independently developed by a Party without any use of or reference to the Confidential Information of the other Party and without
breach of the obligations contained in this Agreement where such independent development can be established by evidence that would be acceptable to a court or other government authority of competent jurisdiction; or 
 5.5.4 has been received by a Party from a third party who is not subject to confidentiality obligations similar to the confidentiality obligations
contained in this Agreement. 
 Notwithstanding anything to the contrary herein, each Party may disclose to its customers, investors,
shareholders, Affiliates and permitted assigns and sublicensees the scope of the License. 
  

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 5.6 Court Orders 
 In the event that a Party or other Person to whom Confidential Information is provided as permitted by this Agreement receives notice indicating that it may or shall be legally compelled to disclose any of the
Confidential Information of the other Party, or it is otherwise subject to disclosure under law or governmental rule, it shall provide the other Party with advance notice (except where impracticable for necessary disclosures, in which case notice
shall be given as soon as practicable) so the other Party may seek a protective order or other appropriate remedy and/or waive compliance with the provisions of this Agreement. In the event that such protective order or other remedy is not obtained
for whatever reason, or that the other Party waives compliance with the provisions of this Agreement, such compelled Person shall furnish only that portion of such Confidential Information in respect of which it is advised by written opinion of
counsel that it is required to disclose. In no event shall a Party’s disclosure of Confidential Information disclosed to it by the other Party, made under court order, rule, or law, but in the absence of a waiver of compliance with the
provisions of this Agreement by the other Party, be deemed a breach of this Agreement by the Party making the necessary disclosure. 
 ARTICLE 6 
 WARRANTIES, INSURANCE AND LIMITATION 
 6.1 Warranties 
 6.1.1 By DPI.
DPI represents and warrants to Infinity that as of the Effective Date: 
 a. to its knowledge, it has the full right and authority to grant
the License and to enter into and fully perform this Agreement; and, 
 b. DPI is not a party to any agreement, contract, instrument, or
document that would in any way prevent DPI from granting the rights granted by this Agreement or from performing all its obligations under this Agreement. 
 6.1.2 By Infinity. Infinity represents and warrants to DPI that as of the Effective Date: 
 a. it has
the full right and authority to enter into and fully perform this Agreement; 
 b. neither Infinity nor any of its Affiliates is a Party to
any agreement, contract, instrument, or document that would in any way prevent Infinity from performing all its obligations under this Agreement; 
 c. Infinity is not insolvent or unable to pay its liabilities as they become due; 
 d. Infinity is not a Party to any proceedings,
involuntary or voluntary, under bankruptcy laws or similar legislation for the relief of debtors, nor proceedings to make an assignment for the benefit of its creditors generally, nor in proceedings for dissolution or 

  

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winding-up (other than by way of voluntary winding-up or dissolution for the purposes of amalgamation or reconstruction), nor has a receiver, manager or
receiver-manager been appointed in respect of any or all of its undertaking or assets; 
 e. Infinity is not aware of any claim asserted,
pending or threatened against it or DPI alleging that the Licensed Products or the DPI Patent Rights infringe the intellectual property rights of any other Person; and 
 f. Infinity agrees as a continuing obligation not to use, and to cause its Affiliates not to use, any DPI Patent Rights at any time hereafter, except as permitted by the License or applicable law. 
 6.2 Disclaimer 
 Except as expressly
set out in this Agreement, DPI and Infinity disclaim all warranties and conditions, whether express or implied, including any warranty or condition as to suitability, merchantability, or fitness for use, and under the United Nations Convention on
Contracts for the International Sale of Goods, with respect to the Licensed Products or any good or product subject to the Intellectual Property Rights. The entire risk as to the results and performance of any products made by Infinity or on its
behalf based upon the DPI Patent Rights is assumed by Infinity. Except as set forth in Section 6.1, DPI and Infinity specifically do not make any representations or warranties, express or implied, concerning the patentability of the DPI Patent
Rights, the validity of any patent, the scope of any patent claim, or whether the exercise of the rights licensed under this Agreement shall or shall not result in infringement of any patent. 
 ARTICLE 7 
 INDEMNIFICATION 
 7.1 Indemnification 
 Infinity and DPI
each respectively agrees to indemnify, defend and hold the other (and each of their directors, officers, employees, Affiliates, successors and permitted assigns) harmless for, from and against any and all losses, liabilities, damages, claims,
disputes, proceedings, costs or expenses (including interest and reasonable attorneys’ fees) (“Losses”) based upon, arising out of or otherwise in respect of the exercise of its rights, or the satisfaction of its obligations,
under this Agreement, but excluding any Losses based upon, arising out of or otherwise in respect of the negligence or intentional misconduct of the other Party. 
 7.2 Procedure for Indemnification 
 In the event that any indemnified Person shall incur (or
anticipate that it may incur in the case of third party claims) any Losses in respect of which indemnity may be sought by such Person pursuant to this Article 7, the indemnified Person shall notify the indemnifying Party promptly; provided,
however, that any delay or failure to notify an indemnifying Party of any claim shall not relieve it from any liability except to the extent that the indemnifying Party demonstrates that it was prejudiced by such delay or failure to notify.
In the case of third party claims, the indemnified Person shall assume the defense of the claim and the indemnifying Party 

  

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may participate, at its own expense, in such defense. Notwithstanding the foregoing, the indemnified Person shall not compromise or settle any third party
claim without the prior written consent of the indemnifying Party, which consent shall not unreasonably withheld or delayed. The Parties agree to negotiate in good faith any dispute which arises concerning a claim hereunder which does not involve a
third party claim or in the event that there is any other dispute relating to indemnification. 
 7.3 Nothing contained in Article 7 is
intended to alter, affect or waive any rights or remedies either Party may have against the other at law or in equity. 
 ARTICLE 8

 TERM AND TERMINATION 
 8.1 Term 
 This Agreement shall be effective as of the Effective Date and shall terminate on the Expiration Date, unless
terminated earlier as permitted by this Agreement. If the Termination Date is the Expiration Date, the License shall convert into a fully paid-up, perpetual, worldwide license, unless already converted as provided in Section 2.1. 
 8.2 Early Termination by DPI 
 DPI
shall have the right to terminate this Agreement before the Expiration Date: 
 a. upon the occurrence of a material breach of this Agreement
by Infinity (including Infinity’ use of the DPI Patent Rights beyond the scope of the License), provided that if the breach is capable of being cured, Infinity has not cured the breach within 30 days after written notice of the
breach (“Notice of Default”) from DPI; or 
 b. if, prior to full payment, Infinity is adjudged bankrupt or insolvent or
files a voluntary petition under any bankruptcy or insolvency or similar legislation for the relief of debtors; or enters into any arrangement, composition or compromise with, or makes an assignment for the benefit of its creditors generally, or if
any proceedings for dissolution or winding-up are commenced (other than by way of voluntary winding-up or dissolution for the purposes of amalgamation or reconstruction), or a receiver, manager or receiver-manager or similar officer is appointed for
Infinity or in respect of any or all of its undertaking or assets which proceedings or whose appointment is not vacated or discharged within 30 days. 
 8.3 Early Termination by Infinity 
 Infinity shall have the right to terminate this Agreement before
the Expiration Date: 
 a. upon the occurrence of a material breach of this Agreement by DPI, provided that if the breach is
capable of being cured, DPI has not cured the breach within 30 days after written notice of the breach (“Notice of Default”) from Infinity; or 
  

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 b. if DPI is adjudged bankrupt or files a voluntary petition under any bankruptcy or similar legislation
for the relief of debtors, or makes an assignment for the benefit of its creditors generally, or if any proceedings for dissolution or winding-up are commenced (other than by way of voluntary winding-up or dissolution for the purposes of
amalgamation or reconstruction), or a receiver, manager or receiver-manager is appointed in respect of any or all of its undertaking or assets which proceedings or whose appointment is not vacated or discharged within 30 days. 
 8.4 Bankruptcy 
 If an event occurs
that would permit DPI or Infinity to terminate this Agreement pursuant to Section 8.2(b) or 8.3(b), respectively, but DPI or Infinity, as applicable, elects not to terminate or is prevented from terminating this Agreement, then notwithstanding
anything in this Agreement to the contrary, the Party which is not the insolvent Party shall not be required to deliver any goods or service to the other Party hereunder. 
 8.5 Result of Termination 
 8.5.1 Upon the termination or expiration of this Agreement: 
 a. the License shall immediately terminate and Infinity’ rights under the License shall terminate; and 
 b. the following provisions (or portions of provisions) of this Agreement shall survive termination: Articles 3, 5, 7 and 9; and Sections 6.2 and 8.5.

 8.5.2 Termination of this Agreement shall not limit either Party from pursuing any other remedies available to it, including injunctive
relief. 
 ARTICLE 9 
 GENERAL 
 9.1 Public Notices 
 No press release or other announcement concerning the matters contemplated by this Agreement shall be made by either Party, without the prior written consent of the other Party (such consent not to be unreasonably
withheld or delayed). 
 9.2 Assignment 
 Neither Party may assign this Agreement except upon the prior written consent of the other Party. In the event that Infinity is acquired, written consent is not required for the license to be assigned to the acquiring
party. 
 9.3 Notices 
 Any notice or other communication required or permitted to be given must be in writing and may be given by any means, including mail service, rush delivery service, facsimile, 

  

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electronic communication, or hand-delivery. Any notice sent by facsimile or electronic communication shall be deemed to have been received on the business
day following the sending. Any notice sent by other means shall be deemed to have been received at the time it is delivered to the applicable address noted below, either to the individual designated below or to an individual at such address having
apparent authority to accept deliveries on behalf of the addressee. Notice of change of address shall also be governed by this Section 9.3 but shall only be effective on actual delivery. Notices and other communications shall be addressed as
follows: 
 if to DPI: 
 Discovery Partners International, Inc. 
 9640 Towne Center Drive 
 San Diego, California 92121 
 Attention: Chief Financial Officer 
 Telecopier No.: 953-546-3081 
 if to Infinity: 
 Infinity
Pharmaceuticals, Inc 
 780 Memorial Drive 
 Cambridge, MA 02139 
 Attention: Director, Technology Licensing 
 Telecopier No: 617-453-1001 
 9.4 Time of the Essence 
 Time is of
the essence of this Agreement. 
 9.5 Further Assurances 
 Each Party shall promptly do, make, execute or deliver, or cause to be done, made, executed or delivered, all such further acts, documents and things as the other Party may reasonably require from time to time for the
purpose of giving effect to this Agreement and shall use commercially reasonable efforts and take all such steps as may be reasonably within its power to implement to their full extent the provisions of this Agreement. 
 9.6 Invalidity of Provision 
 Any
provision of this Agreement that is prohibited or unenforceable in any jurisdiction will, as to that jurisdiction, be ineffective to the extent of the prohibition or unenforceability without invalidating the remaining provisions and any such
prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. For any provision so severed there shall be deemed substituted a like provision to accomplish the intent of
the Parties as closely as possible to the provision as drafted, as determined by any court or arbitrator having jurisdiction over any relevant proceedings, to the extent permitted by the applicable law. 
  

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 9.7 Governing Law 
 This Agreement shall be governed by and construed in accordance with the laws of the State of New York, without regard to conflicts of laws principles. 
 9.8 Consent to Jurisdiction 
 Each
Party irrevocably submits to the non-exclusive jurisdiction of the Federal and State Courts located in New York, New York, for the purposes of any suit, action or other proceeding arising out of this Agreement. Each Party further agrees that service
of any process, summons, notice or document by United States certified or registered mail to such Party’s address set forth in Section 9.3 shall be effective service of process in any action, suit or proceeding in New York with respect to
any matters to which it has submitted to jurisdiction as set forth in the immediately preceding sentence. Each Party irrevocably and unconditionally waives any objection to the laying of venue of any action, suit or proceeding arising out of this
Agreement in the Federal and State Courts located in New York, New York, and hereby irrevocably and unconditionally waives and agrees not to plead or claim in any such court that any such action, suit or proceeding brought in such court has been
brought in an inconvenient forum. 
 9.9 Remedies 
 Each Party agrees that if the other Party shall breach this Agreement, the other Party shall not be liable for consequential, exemplary, incidental, punitive or special damages. 
 9.10 Entire Agreement, Waiver 
 This
Agreement constitutes the entire agreement between the Parties pertaining to the subject matter hereof. There are no warranties, conditions, or representations (including any that may be implied by statute) and there are no agreements in connection
with such subject matter except as specifically set forth or referred to in this Agreement. No reliance is placed on any warranty, representation, opinion, advice or assertion of fact made by any Party or its directors, officers, employees,
representatives or agents, to the other Party or its directors, officers, employees, representatives or agents, except to the extent that the same has been reduced to writing and included as a term of this Agreement. Accordingly, there shall be no
liability, either in tort or in contract, assessed in relation to any such warranty, representation, opinion, advice or assertion of fact, except to the extent aforesaid. 
 9.11 Waiver of Jury Trial 
 Each Party hereby waives, to the fullest extent permitted by law, any
right to trial by jury of any claim, demand, action or cause of action (i) arising under this Agreement or (ii) in any way connected with or related or incidental to the dealings of the Parties in respect of this Agreement, in each case
whether now existing or hereafter arising, and whether in contract, tort, equity or otherwise. Each Party hereby agrees and consents that any such claim, demand, action or cause of action shall be decided by court trial without a jury and that the
Parties may file an original counterpart of a copy of this Agreement with any court as written evidence of the consent of the Parties to the waiver of their right to trial by jury. 
  

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 9.12 Relationship of Parties 
 The Parties intend that the relationship created between them by this Agreement be that of independent contractors. This Agreement is not to be construed
as creating any partnership, principal-agent, master-servant, joint venture or similar relationship between the Parties. All rights, duties, obligations and liabilities of the Parties shall be separate, individual and several and not joint or joint
and several. Neither Party has any authority to, nor shall it hold itself out as having authority to, nor shall it, enter into any contract or commitment in the name of or on behalf of the other Party nor shall either Party bind or obligate the
other in any respect whatsoever other than as specifically permitted by this Agreement. 
 9.13 Counterparts 
 This Agreement may be signed in counterparts. Each counterpart shall constitute an original document and the counterparts, taken together, shall
constitute one and the same instrument. A Party may evidence its execution and delivery of this Agreement by signing and faxing this Agreement to the other Party and promptly thereafter mailing the signed original of this Agreement to the other
Party. 
  

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 IN WITNESS WHEREOF, the Parties have executed this License Agreement as of the day and year first
above written. 
  

			
	INFINITY PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Robert Millman

		
	Name:	 	Robert Millman
	Title:	 	Chief Patent Counsel/Associate General Counsel
	Date:	 	April 7, 2003
	
	DISCOVERY PARTNERS INTERNATIONAL, INC.
		
	By:	 	 /s/ Craig Kussman

		
	Name:	 	Craig Kussman
	Title:	 	Chief Financial Officer
	Date:	 	April 4, 2003

  

 14License Agreement by and between Infinity and Amgen

 Exhibit 10.45 
 Amgen and Infinity Confidential 
 Confidential Materials omitted and filed separately with the

 Securities and Exchange Commission. Asterisks denote omissions. 
 LICENSE AGREEMENT 
 BY AND BETWEEN 
 INFINITY PHARMACEUTICALS, INC. 
 AND

 AMGEN INC. 
 Amgen Contract No.
200315899-002 

			
	 ARTICLE 1
	  	
	 DEFINITIONS
	  	1
	 Section 1.1 Affiliate
	  	1
	 Section 1.2 [**]
	  	2
	 Section 1.3 [**] Information
	  	2
	 Section 1.4 Omitted.
	  	2
	 Section 1.5 Omitted.
	  	2
	 Section 1.6 Amgen Target
	  	2
	 Section 1.7 Analog
	  	2
	 Section 1.8 [**]
	  	2
	 Section 1.9 Business Day
	  	2
	 Section 1.10 Combined Term
	  	2
	 Section 1.11 Confidential Information
	  	2
	 Section 1.12 Control or Controlled
	  	3
	 Section 1.13 Development or Develop
	  	3
	 Section 1.14 Drug Discovery Program
	  	3
	 Section 1.15 EMEA
	  	3
	 Section 1.16 [**]
	  	3
	 Section 1.17 [**]
	  	3
	 Section 1.18 [**]
	  	3
	 Section 1.19 [**]
	  	3
	 Section 1.20 [**]
	  	3
	 Section 1.21 FDA
	  	4
	 Section 1.22 First Commercial Sale
	  	4
	 Section 1.23 Omitted.
	  	4
	 Section 1.24 Omitted.
	  	4
	 Section 1.25 GAAP
	  	4
	 Section 1.26 Good Laboratory Practices or GLP
	  	4
	 Section 1.27 Hit
	  	4
	 Section 1.28 Omitted.
	  	4
	 Section 1.29 Hit-To-Lead Chemistry Program
	  	4
	 Section 1.30 IND
	  	4
	 Section 1.31 Omitted.
	  	4
	 Section 1.32 Infinity Intellectual Property
	  	4
	 Section 1.33 Infinity Know-How
	  	4
	 Section 1.34 Infinity Patent Rights
	  	5
	 Section 1.35 Omitted.
	  	5
	 Section 1.36 Omitted.
	  	5
	 Section 1.37 Know-How
	  	5
	 Section 1.38 Law or Laws
	  	5
	 Section 1.39 Lead
	  	5
	 Section 1.40 Lead Optimization Program
	  	5
	 Section 1.41 Library Compound
	  	5
	 Section 1.42 Omitted.
	  	5
	 Section 1.43 [**]
	  	5
	 Section 1.44 Library Compound Information
	  	5

  

 i 
 Amgen
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	 Section 1.45 Library Compound Structure Information
	  	5
	 Section 1.46 MHW
	  	5
	 Section 1.47 Omitted.
	  	6
	 Section 1.48 NDA
	  	6
	 Section 1.49 Net Sales
	  	6
	 Section 1.50 Non-Royalty-Bearing Product
	  	6
	 Section 1.51 Omitted.
	  	6
	 Section 1.52 Party or Parties
	  	6
	 Section 1.53 Patent Rights
	  	7
	 Section 1.54 Phase IIB Study
	  	7
	 Section 1.55 Phase III Study
	  	7
	 Section 1.56 Program Compound
	  	7
	 Section 1.57 Regulatory Approval
	  	7
	 Section 1.58 Regulatory Authority
	  	7
	 Section 1.59 Omitted.
	  	7
	 Section 1.60 Omitted.
	  	7
	 Section 1.61 Omitted.
	  	7
	 Section 1.62 Royalty-Bearing Product
	  	7
	 Section 1.63 Omitted.
	  	7
	 Section 1.64 Sublicensee(s)
	  	7
	 Section 1.65 Omitted.
	  	8
	 Section 1.66 Synthetic Methodology and Pathways
	  	8
	 Section 1.67 Target
	  	8
	 Section 1.68 Territory
	  	8
	 Section 1.69 Third Party
	  	8
	 Section 1.70 Additional Definitions
	  	8
		
	 ARTICLE 2
	  	
	 USE OF LIBRARY COMPOUNDS
	  	9
	 Section 2.1 DRUG DISCOVERY PROGRAMS.
	  	9
	 Section 2.2 DESTRUCTION OF UNUSED QUANTITIES OF LIBRARY COMPOUNDS.
	  	9
		
	 ARTICLE 3
	  	
	 LICENSES
	  	11
	 Section 3.1 INFINITY GRANTS.
	  	11
	 Section 3.2 LIMITED AMGEN GRANT
	  	12
	 Section 3.3 SUBLICENSE RIGHTS
	  	13
	 Section 3.4 SECTION 365(N) OF THE BANKRUPTCY CODE
	  	13
	 Section 3.5 NO IMPLIED LICENSES OR RIGHTS
	  	13
	 Section 3.6 [**].
	  	13
		
	 ARTICLE 4
	  	
	 FINANCIAL PROVISIONS
	  	14
	 Section 4.1 CONTINUATION FEE
	  	14
	 Section 4.2 [Omitted]
	  	14
	 Section 4.3 MILESTONE PAYMENTS.
	  	14

  

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Contract No. 200315899-002 

			
	 Section 4.4 SUCCESS PAYMENTS
	  	16
	 Section 4.5 ROYALTIES.
	  	17
	 Section 4.6 ROYALTY REPORTS; PAYMENTS
	  	18
	 Section 4.7 AUDITS
	  	18
	 Section 4.8 TAX MATTERS.
	  	19
	 Section 4.9 UNITED STATES DOLLARS
	  	20
	 Section 4.10 CURRENCY EXCHANGE
	  	20
	 Section 4.11 LATE PAYMENTS
	  	20
		
	 ARTICLE 5
	  	
	 INTELLECTUAL PROPERTY OWNERSHIP, PROTECTION AND RELATED MATTERS
	  	20
	 Section 5.1 OWNERSHIP.
	  	20
	 Section 5.2 THIRD PARTY INFRINGEMENT.
	  	21
		
	 ARTICLE 6
	  	
	 CONFIDENTIALITY
	  	22
	 Section 6.1 CONFIDENTIAL INFORMATION
	  	22
	 Section 6.2 PERMITTED DISCLOSURE.
	  	23
	 Section 6.3 EMPLOYEE AND ADVISOR OBLIGATIONS
	  	24
	 Section 6.4 TERM
	  	24
	 Section 6.5 PUBLICATIONS
	  	24
		
	 ARTICLE 7
	  	
	 TERM AND TERMINATION
	  	24
	 Section 7.1 AGREEMENT TERM
	  	24
	 Section 7.2 TERMINATION FOR CONVENIENCE
	  	24
	 Section 7.3 TERMINATION FOR MATERIAL BREACH
	  	24
	 Section 7.4 EFFECT OF TERMINATION; ACCRUED RIGHTS; SURVIVING OBLIGATIONS.
	  	25
		
	 ARTICLE 8
	  	
	 REPRESENTATIONS, WARRANTIES AND COVENANTS
	  	25
	 Section 8.1 REPRESENTATION OF AUTHORITY; CONSENTS
	  	25
	 Section 8.2 NO CONFLICT
	  	26
	 Section 8.3 KNOWLEDGE OF PENDING OR THREATENED LITIGATION
	  	26
	 Section 8.4 EMPLOYEE AND CONSULTANT OBLIGATIONS.
	  	26
	 Section 8.5 INTELLECTUAL PROPERTY
	  	27
	 Section 8.6 PRIOR OBLIGATIONS
	  	27
	 Section 8.7 DISCLAIMER OF WARRANTY
	  	27
		
	 ARTICLE 9
	  	
	 MISCELLANEOUS PROVISIONS
	  	27
	 Section 9.1 INDEMNIFICATION.
	  	27
	 Section 9.2 Dispute Resolution.
	  	28
	 Section 9.3 GOVERNING LAW
	  	29
	 Section 9.4 ASSIGNMENT
	  	29

  

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	 Section 9.5 ENTIRE AGREEMENT; AMENDMENTS
	  	29
	 Section 9.6 NOTICES
	  	29
	 Section 9.7 FORCE MAJEURE
	  	30
	 Section 9.8 COMPLIANCE WITH LAWS
	  	30
	 Section 9.9 PUBLIC ANNOUNCEMENTS
	  	30
	 Section 9.10 USE OF NAMES, LOGOS OR SYMBOLS
	  	31
	 Section 9.11 INDEPENDENT CONTRACTORS
	  	31
	 Section 9.12 NO STRICT CONSTRUCTION
	  	31
	 Section 9.13 HEADINGS
	  	31
	 Section 9.14 NO IMPLIED WAIVERS; RIGHTS CUMULATIVE
	  	31
	 Section 9.15 SEVERABILITY
	  	31
	 Section 9.16 EXECUTION IN COUNTERPARTS
	  	32
	 Section 9.17 NO THIRD PARTY BENEFICIARIES
	  	32
	 Section 9.18 PERFORMANCE BY AFFILIATES
	  	32
	 Section 9.19 NO CONSEQUENTIAL DAMAGES
	  	32
	 Section 9.20 Exhibits
	  	32
		
	 EXHIBITS
	  	
	 Exhibit A    –    Library Compound Delivery Requirements
	  	
	 Exhibit B    –    Second Success Triggers
	  	
	 Exhibit C    –    Form of Press Release
	  	

  

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Contract No. 200315899-002 

 LICENSE AGREEMENT 
 THIS LICENSE AGREEMENT (the “Agreement”) dated the 7th day of July,
2006 (the “Effective Date”) is by and between INFINITY PHARMACEUTICALS, INC., a corporation organized and existing under the laws of the State of Delaware and having its principal office at 780 Memorial Drive, Cambridge,
Massachusetts 02139 (“Infinity”), and AMGEN INC., a corporation organized and existing under the laws of the State of Delaware and having its principal office at One Amgen Center Drive, Thousand Oaks, California 91320-1799
(“Amgen”). 
 INTRODUCTION 
 WHEREAS, Infinity and Amgen are each in the business of discovering, developing and commercializing pharmaceutical products. 
 WHEREAS, Infinity Controls certain technology for the creation of large numbers of complex, natural-compound-like compounds for the purpose of screening biological targets to identify potential human
therapeutics.  
 WHEREAS, Infinity and Amgen entered into a Collaboration and License Agreement as of December 19, 2003
(the “Prior Agreement Effective Date”); such agreement, the “Prior Agreement”). 
 WHEREAS, Infinity and Amgen
wish to extend and clarify certain rights under the Prior Agreement on the terms and conditions herein. 
 WHEREAS, Infinity and Amgen
agree that after the Effective Date Infinity has [**] of the Prior Agreement and had [**] of the Prior Agreement. 
 NOW,
THEREFORE, Infinity and Amgen agree as follows: 
 ARTICLE 1 
 DEFINITIONS 
 When used in this Agreement, each of the following terms shall
have the meanings set forth in this Article 1: 
 Section 1.1 Affiliate. “Affiliate” shall mean any corporation,
company, partnership, joint venture and/or firm that controls, is controlled by, or is under common control with a specified person or entity. For purposes of this Section 1.1, “control” shall be presumed to exist if one of the
following conditions is met: (a) in the case of corporate entities, direct or indirect ownership of more than fifty percent (50%) of the stock or shares having the right to vote for the election of directors, and (b) in the case of
non-corporate entities, direct or indirect ownership of more than fifty percent (50%) of the equity interest with the power to direct the management and policies of such non-corporate entities. The Parties acknowledge that in the case of
certain entities organized under the Laws of certain countries outside of the United States, the maximum 

  

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Contract No. 200315899-002 

 
percentage ownership permitted by Law for a foreign investor may be less than fifty percent (50%), and that in such case such lower percentage shall be
substituted in the preceding sentence, provided that such owner has the power to direct the management and policies of such entity. 
 Section 1.2 [**] shall mean [**]. 
 Section 1.3 [**] Information. “[**] Information” shall mean
[**]. 
 Section 1.4 Omitted. 
 Section 1.5 Omitted. 
 Section 1.6 Amgen Target. “Amgen Target” shall mean
a Target against which Amgen or an Amgen Affiliate screens a Library Compound or an Analog. 
 Section 1.7 Analog.
“Analog” shall mean any compound that is derived by Amgen from a Library Compound. As used herein, a compound shall be deemed to have been “derived from” a Library Compound if it is a chemical modification to a Library Compound
which: (a) [**], (b) [**], or (c) [**]. 
 Section 1.8 [**]. “[**]” shall mean, with respect to a [**] for
which Amgen [**], each other [**] that (a) is structurally related to, and is to be directed to the same [**] as, the relevant [**] for which Amgen [**] and (b) Amgen designates in accordance with Section 3.6.2. 
 Section 1.9 Business Day. “Business Day” shall mean a day other than a Saturday or Sunday or Federal holiday. 
 Section 1.10 Combined Term. “Combined Term” shall mean the period commencing on the Prior Agreement Effective Date and ending on
the two (2) year anniversary of the Effective Date. 
 Section 1.11 Confidential Information. “Confidential
Information” shall mean (a) the [**], all [**] Information and [**] Information (which, with respect to the [**] Information, shall be deemed to be Amgen Confidential Information for as long as it is subject to the respective licenses
granted under Sections 3.1), which shall be deemed to be Amgen Confidential Information (subject to the provisions of Section 2.2), (b) all information relating to Library Compounds (other than [**]) and, following the termination of the
respective licenses granted under Sections 3.1, any [**] Information, which shall be deemed to be Infinity Confidential Information, and (c) all other proprietary documents, technology, Know-How or other information (whether or not patentable)
actually disclosed by one Party to the other pursuant to the Prior Agreement or this Agreement or created by Infinity for Amgen’s benefit pursuant to the Prior Agreement or this Agreement and marked as “confidential” or
“proprietary” (or if disclosed orally, confirmed in writing within thirty (30) days thereafter). 
  

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 Section 1.12 Control or Controlled. “Control” or “Controlled”
shall mean with respect to any (a) material, document, item of information, method, data or other Know-How or (b) intellectual property right, the possession (whether by ownership or license, other than by a license granted pursuant to the
Prior Agreement or this Agreement) by a Party or its Affiliates of the ability to grant to the other Party access, ownership, a license and/or a sublicense as provided herein without violating the terms of any agreement or other arrangement with any
Third Party entered into or existing as of the time such Party or its Affiliates would first be required hereunder to grant the other Party such access, ownership, license, or sublicense. 
 Section 1.13 Development or Develop. “Development” or “Develop” shall mean, with respect to a compound,
preclinical and clinical drug development activities, including, among other things: test method development and stability testing, toxicology, formulation, process development, manufacturing scale-up, development-stage manufacturing, quality
assurance/quality control procedure development and performance with respect to clinical materials, statistical analysis and report writing and clinical studies. When used as a verb, “Develop” means to engage in Development. 
 Section 1.14 Drug Discovery Program. “Drug Discovery Program” shall mean an Amgen research program commenced during the Combined
Term, which is focused on researching and developing (a) a Library Compound directed to an Amgen Target, which Library Compound was confirmed by Amgen as a [**] or (b) [**] was derived from a Library Compound that was confirmed by Amgen as
a [**]. 
 Section 1.15 EMEA. “EMEA” shall mean the European Medicines Evaluation Agency, or a successor agency
thereto. 
 Section 1.16 [**] shall mean the information related to the [**] provided by Amgen to Infinity pursuant to [**].

 Section 1.17 [**]. “[**]” shall mean each [**] with respect to which [**] to Amgen pursuant to Sections 3.1.4 and
3.6.1 in connection with [**] of the [**] by operation of Section 3.6.2. 
 Section 1.18 [**] Information. “[**]
Information” shall mean all structural, process and other information relating to an [**] provided by Infinity to Amgen pursuant to the Prior Agreement and all such information generated by Amgen. For the avoidance of doubt, [**] Information
includes [**] and [**] and [**] with respect to the relevant [**]. 
 Section 1.19 [**] Royalty-Bearing Product. “[**]
Royalty-Bearing Product” shall mean a Royalty-Bearing Product that contains an [**]. 
 Section 1.20 [**]. “[**]”
shall mean the [**] the Effective Date and [**]. 
  

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 Section 1.21 FDA. “FDA” shall mean the United States Food and Drug Administration,
or a successor agency thereto. 
 Section 1.22 First Commercial Sale. “First Commercial Sale” shall mean, for each
Royalty-Bearing Product, on a country-by-country basis, [**] of such Royalty-Bearing Product, to a Third Party by Amgen or its Affiliates or Sublicensees, in a country in the Territory [**] in such country. Sales for test marketing, sampling and
promotional uses, clinical trial purposes or compassionate or similar use shall not be considered to constitute a First Commercial Sale. 
 Section 1.23 Omitted. 
 Section 1.24 Omitted. 
 Section 1.25 GAAP. “GAAP” shall mean United States generally accepted accounting principles. 
 Section 1.26 Good Laboratory Practices or GLP. “Good Laboratory Practices” or “GLP” shall mean the then-current
good laboratory practice standards promulgated or endorsed by the FDA as defined in 21 C.F.R. Part 58, and comparable regulatory standards in jurisdictions outside the United States. 
 Section 1.27 Hit. “Hit” shall mean a [**] (a) that is confirmed as active against an Amgen Target, or (b) for which [**],
which is [**]. For purposes of this Section 1.27, [**] shall mean that a [**] or [**] are [**]. 
 Section 1.28 Omitted.

 Section 1.29 Hit-To-Lead Chemistry Program. “Hit-To-Lead Chemistry Program” shall mean chemistry activities directed
to the generation of one or more Analogs with the goal of generating [**]. 
 Section 1.30 IND. “IND” shall mean
(a) (i) an Investigational New Drug Application, as defined in the U.S. Federal Food, Drug and Cosmetic Act, as amended, and the regulations promulgated thereunder, that is required to be filed with the FDA before beginning clinical
testing of a pharmaceutical product in human subjects, or any successor application or procedure and (ii) any foreign counterpart of such an Investigational New Drug Application, and (b) all supplements and amendments that may be filed
with respect to the foregoing. 
 Section 1.31 Omitted. 
 Section 1.32 Infinity Intellectual Property. “Infinity Intellectual Property” shall mean Infinity Know-How and Infinity Patent
Rights. 
 Section 1.33 Infinity Know-How. “Infinity Know-How” shall mean Know-How Controlled by Infinity during the
Combined Term, including without limitation Library Compound Information. 
  

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 Section 1.34 Infinity Patent Rights. “Infinity Patent Rights” shall mean Patent
Rights Controlled by Infinity. 
 Section 1.35 Omitted. 
 Section 1.36 Omitted. 
 Section 1.37 Know-How. “Know-How” shall mean any information and materials, whether proprietary or not and whether patentable or not, including without limitation ideas, concepts, formulas, methods, procedures,
designs, compositions, plans, documents, data, inventions, discoveries, works of authorship, compounds and biological materials, but excluding any such information or materials disclosed in Patent Rights. 
 Section 1.38 Law or Laws. “Law” or “Laws” shall mean all laws, statutes, rules, regulations, ordinances and other
pronouncements having the effect of law of any federal, national, multinational, state, provincial, county, city or other political subdivision, domestic or foreign. 
 Section 1.39 Lead. “Lead” shall mean a Library Compound or an Analog which meets Amgen’s then current criteria for committing resources commensurate with its other lead
optimization programs. 
 Section 1.40 Lead Optimization Program. “Lead Optimization Program” shall mean the
formation by Amgen of a program to perform all activities directed to the optimization of a Lead for purposes of identifying a clinical candidate and filing an IND. 
 Section 1.41 Library Compound. “Library Compound” shall mean a compound that Infinity delivered pursuant to the Prior Agreement. 
 Section 1.42 Omitted. 
 Section 1.43 [**]. “[**]” shall mean [**] with respect to a [**], if any, as further described in Section 3.6. 
 Section 1.44 Library Compound Information. “Library Compound Information” shall mean structural, process or other information relating to a Library Compound, which is Controlled by Infinity and was delivered to Amgen
by Infinity pursuant to the Prior Agreement. For the avoidance of doubt, Library Compound Information includes [**]. 
 Section 1.45
Library Compound Structure Information. “Library Compound Structure Information” shall mean documentation of the molecular formula and molecular structure of each Library Compound that is Controlled by Infinity and which Infinity
delivered to Amgen pursuant to the Prior Agreement. 
 Section 1.46 MHW. “MHW” shall mean the Japanese Ministry of
Health and Welfare, or a successor agency thereto. 
  

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 Section 1.47 Omitted. 
 Section 1.48 NDA. “NDA” shall mean (a) (i) a New Drug Application submitted to the FDA, or any successor application or
procedure, and (ii) any foreign counterpart of such a New Drug Application, and (b) all supplements and amendments, including supplemental New Drug Applications (and any foreign counterparts) that may be filed with respect to the
foregoing. 
 Section 1.49 Net Sales. “Net Sales” shall mean all amounts [**] received by Amgen, its Affiliates or its
Sublicensees from sales of a [**] by Amgen, its Affiliates and its Sublicensees, to Third Parties (but not including [**], less the following deductions to the extent specifically relating to sales of the Royalty-Bearing Product and provided
that any such deduction shall be deducted only once: 
 (a) [**] including, but not limited to, [**]; 
 (b) [**] but not including [**]; 
 (c) [**] including, but not limited to [**]; and 
 (d) [**]; and 
 (e) [**]. 
 In the case of any sale of [**], such as
[**], Net Sales shall be calculated on [**]. 
 Section 1.50 Non-Royalty-Bearing Product. “Non-Royalty-Bearing Product”
shall mean any product containing [**] that is not a Royalty-Bearing Product. 
 Section 1.51 Omitted. 
 Section 1.52 Party or Parties. “Party” shall mean Amgen or Infinity. “Parties” shall mean Amgen and Infinity.

  

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 Section 1.53 Patent Rights. “Patent Rights” shall mean all existing patents and
patent applications and all patent applications hereafter filed and patents hereafter issued, including without limitation any continuations, continuations-in-part, divisions, provisionals or any substitute applications, any patent issued with
respect to any such patent applications, any reissue, reexamination, renewal or extension (including any supplemental protection certificate) of any such patent, and any confirmation patent or registration patent or patent of addition based on any
such patent, and all foreign counterparts of any of the foregoing. 
 Section 1.54 Phase IIB Study. “Phase IIB Study”
shall mean a well controlled dose ranging clinical study to evaluate the efficacy and safety of a candidate drug in the targeted patient population and to define the optimal dosing regimen. 
 Section 1.55 Phase III Study. “Phase III Study” shall mean a well controlled clinical study commenced after the completion of a
Phase IIB Study to confirm with statistical significance the efficacy and safety of a candidate drug in targeted patient populations, performed to obtain Regulatory Approval of a product. 
 Section 1.56 Program Compound. “Program Compound” shall mean an [**] or [**]. 
 Section 1.57 Regulatory Approval. “Regulatory Approval” shall mean any and all approvals (excluding any applicable governmental
price and reimbursement approvals), licenses, registrations, or authorizations of any federal, national, multinational, state, provincial or local regulatory agency, department, bureau or other governmental entity that are necessary and sufficient
for the marketing and sale of a product in a country or group of countries. 
 Section 1.58 Regulatory Authority.
“Regulatory Authority” shall mean the FDA in the United States and EMEA in the EU and the MHW in Japan. 
 Section 1.59
Omitted. 
 Section 1.60 Omitted. 
 Section 1.61 Omitted. 
 Section 1.62 Royalty-Bearing Product. “Royalty-Bearing
Product” shall mean a pharmaceutical composition in finished product form comprising a [**], provided, that such [**] is (a) [**]or (b) [**] that was confirmed by [**] during the Combined Term. 
 Section 1.63 Omitted. 
 Section 1.64 Sublicensee(s). “Sublicensee(s)” shall mean any and all Third Party(ies) to which Amgen grants any right to research, develop, make, use, sell, offer for sale or import Royalty-Bearing Products in
accordance with Section 3.3 hereof. Solely for purposes of computation of royalties payable to Infinity under Section 4.5 of this Agreement, a Third Party(ies) who is granted only the right to sell a Royalty-Bearing Product (such as a
wholesaler, distributor, contract sales force or other person providing products directly to patients in a home health care setting, as long as Amgen, its Affiliate or Sublicensee records the sales of such Royalty-Bearing Product upon transfer to
such Third Party) or to use a Royalty-Bearing Product (such as a customer receiving an implied license as a consequence of purchase) shall not be considered a Sublicensee(s). 
  

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 Section 1.65 Omitted. 
 Section 1.66 Synthetic Methodology and Pathways. “Synthetic Methodology and Pathways” shall mean, with respect to a Library
Compound, the synthetic scheme that Infinity used to synthesize the Library Compound, which Infinity delivered to Amgen pursuant to the Prior Agreement. 
 Section 1.67 Target. “Target” shall mean a protein or polypeptide, which is involved in a biological process as well as [**]. 
 Section 1.68 Territory. “Territory” shall mean all the countries of the world. 
 Section 1.69 Third Party. “Third Party” shall mean any person or entity other than a Party or any of its Affiliates. 
 Section 1.70 Additional Definitions. Each of the following definitions is set forth in the section of this Agreement indicated below:

  

			
	 DEFINITION
	    	 SECTION

	Agreement	    	Preamble
	Amgen	    	Preamble
	Amgen Indemnified Parties	    	9.1.2
	Amgen Independent Compounds	    	5.2.4
	Amgen Third Party Payments	    	4.5.1(d)
	Bankruptcy Code	    	3.4
	Bound Party	    	6.1
	Controlling Party	    	6.1
	Effective Date	    	Preamble
	Executive Officers	    	9.2.1
	[**]	    	4.4.1
	[**]	    	4.4.1
	[**]	    	4.4.1
	[**]	    	4.4.1
	[**]	    	4.4.1
	Infinity	    	Preamble
	Infinity Indemnified Parties	    	9.1.1
	[**]	    	3.6.1(c)
	Med Chem Group	    	Exhibit A
	Molecular Structure Group	    	Exhibit A
	Patent Prosecution	    	5.1.3
	Prior Agreement	    	Preamble
	Prior Agreement Effective Date	    	Preamble
	Program Coordinator	    	2.6.1
	Royalty Term	    	4.5.1(c)
	Second Back-Up Selection Date	    	3.6.2
	Second Success Payment	    	4.4.2
	Severed Clause	    	9.15
	Taxes	    	4.8.1

  

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 ARTICLE 2 
 USE OF LIBRARY COMPOUNDS 
 Section 2.1 DRUG DISCOVERY PROGRAMS. 
 2.1.1 Amgen shall use reasonable efforts consistent with standards in the pharmaceutical and biotechnology industries to maintain a reliable record
relating to the existence of each Drug Discovery Program, including notations as to when particular [**] were designed, discovered or synthesized by Amgen in the course of a Drug Discovery Program. With respect to each [**], which Amgen determines
to be a Hit during the Combined Term, Amgen shall analyze, unless it had previously done so, whether the [**] is derived is a Hit against the same Amgen Target. In the event that Infinity reasonably has reason to believe that any pharmaceutical
compound sold or offered for sale by or on behalf of Amgen is [**], Infinity may request from time to time on a reasonable basis, and Amgen shall provide, (a) [**], and (b) [**]. In the event that the Parties dispute whether [**], either
Party may seek the resolution of such dispute in accordance with Section 9.2. 
 2.1.2 Amgen shall notify Infinity of the
existence of each Drug Discovery Program, by providing to Infinity (a) a coded identifier for the Library Compound(s) that achieved the status of Hit and (b) a coded identifier for the Amgen Target(s) against which such Library Compound(s)
was confirmed to be a Hit. 
 2.1.3 Amgen shall be responsible for performing all biological assays it, in its sole discretion, deems
appropriate in its Drug Discovery Program(s) (if any), and Infinity shall have no responsibility for performing any biological assays. 
 Section 2.2 DESTRUCTION OF UNUSED QUANTITIES OF LIBRARY COMPOUNDS. 
  

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 2.2.1 
 (a) At the end of the Combined Term, 
 (i) Amgen shall destroy all unused quantities of
Library Compounds except for unused quantities of Library Compounds confirmed by Amgen to be Hits during the Combined Term; 
 (ii)
Amgen shall use commercially reasonable efforts to destroy all Library Compound Information, including all smile string information, in its possession, except for (A) [**] copies of all written materials delivered to Amgen by Infinity
(whether in electronic or hard-copy form) retained by Amgen for the purposes of managing Patent Prosecution and its non-use obligations (including avoiding claiming Library Compounds in patent applications to the extent required by
Section 5.1.3(c)) under this Agreement and (B) Library Compound Information recorded in Amgen laboratory notebooks or other business records maintained in the ordinary course of Amgen’s business and (C) Library Compound
Information relating to Library Compounds confirmed by Amgen as Hits during the Combined Term for uses licensed under Article 3 of this Agreement. Amgen shall use commercially reasonable efforts to terminate its use of all Library Compound
Information in its possession (except to the extent permitted in clauses (A) and (C)). Amgen shall use commercially reasonable efforts to notify relevant employees and agents of its non-use obligations hereunder. 
 (b) [**], 
 (i) Amgen shall
destroy all unused quantities of Library Compounds confirmed by Amgen to be Hits during the Combined Term, except for unused quantities of (A) [**] and [**] related thereto, and (B) [**] that are the subject of a [**], provided that
upon termination of such [**], Amgen shall destroy unused quantities of such Library Compounds; and 
 (ii) Amgen shall use
commercially reasonable efforts to destroy all Library Compound Information, including all smile string information, in its possession relating to Library Compounds confirmed by Amgen as Hits during the Combined Term except for
(A) [**] archival copies of all written materials delivered to Amgen by Infinity (whether in electronic or hard-copy form) retained by Amgen for the purposes of managing Patent Prosecution and its other non-use obligations (including
avoiding claiming Library Compounds in patent applications to the extent required by Section 5.1.3(c)) under this Agreement and (B) Library Compound Information recorded in Amgen laboratory notebooks or other business records maintained in
the ordinary course of Amgen’s business, and (C) Library Compound Information relating to [**] for uses licensed under Article 3 of this Agreement and potential [**] related thereto and (D) Library Compound Information relating to
[**] for uses licensed under Article 3 of this Agreement, provided that upon termination of any such Drug Discovery Program (other than as a result of commercialization of a Royalty-Bearing Product relating thereto) Amgen shall use
commercially reasonable efforts to destroy such Library Compound Information. Amgen shall use commercially reasonable efforts to terminate use of all Library Compound Information in its possession (except to the extent permitted in clauses (A),
(C) and (D)). Amgen shall use commercially reasonable efforts to notify relevant employees and agents of its non-use obligations hereunder. 
  

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 2.2.2 At all times during and after the end of the Combined Term, Amgen shall have the continuing
right to retain and use all [**] and [**] (to the extent permitted by the other provisions of this Agreement), provided that this provision is not intended to act as the grant of rights under any valid and enforceable Infinity Patent
Rights. 
 2.2.3 For so long as Amgen has physical access to Library Compounds, the identity of such compounds will be determined by
the molecular formula and molecular structure described in the Library Compound Structure Information, provided that the structure of each Library Compound shall be deemed to be the structure identified to Amgen in the Library Compound
Information provided by Infinity to Amgen under the Prior Agreement except to the extent that Amgen has actual knowledge that the compound(s) in a given well have a different structure and Amgen actually knows that structure. At the end of the
period in which Amgen has physical access to Library Compounds, the Library Compound Information provided by Infinity to Amgen under the Prior Agreement will be deemed to be conclusive for purposes of determining the Parties’ rights and
obligations under this Agreement; provided that, any more accurate structural information actually known by Amgen during the period in which Amgen has physical access to the Library Compounds will be used to identify such compounds at
the end of such period. 
 2.2.4 The provisions of Exhibit A shall apply with respect to the Synthetic Methodology and Pathways
information and the Library Compound Structure Information. 
 ARTICLE 3 
 LICENSES 
 Section 3.1 INFINITY GRANTS. 
 3.1.1 License With Respect to Library Compounds. Infinity hereby grants to Amgen a worldwide, non-exclusive license, under Infinity Intellectual
Property, to use Library Compounds and Library Compound Information for research purposes in the discovery of Hits to Amgen Targets, performing Hit-to-Lead Chemistry Programs and Lead Optimization Programs and in the Development of Royalty-Bearing
Products that contain Library Compounds (which license shall include the right to use Synthetic Methodology and Pathways solely to synthesize Library Compounds which have been identified as Hits (and Library Compounds structurally related thereto),
and [**] that derive from such Library Compounds, for the purpose of performing Drug Discovery Programs). With respect to any Library Compound confirmed by Amgen as a Hit during the Combined Term, the license set forth in this Section 3.1.1
shall survive until the permanent cessation by Amgen of all research and Development activities with respect to the relevant Library Compound or Program Compound that commenced with confirmation of such Library Compound as a Hit and thereupon
expire. With respect to any [**], the license set forth in this Section 3.1.1 shall [**], but subject to [**] with respect to the [**] upon [**] pursuant to Section 3.6.1 of this Agreement and such license shall [**] (subject to any terms
and conditions of this Agreement expressly providing for [**]). Subject to Section 3.3, the licenses set forth in this Section 3.1.1 shall further include the right to grant sublicenses to Affiliates of Amgen and to Third Party
collaborators (provided such collaborators are under an obligation to not determine the structure of any Library Compound) and Third Party contractors engaged solely on a fee-for-service basis. 
  

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 3.1.2 Licenses With Respect to Analogs. Infinity hereby grants to Amgen a worldwide, perpetual
(subject to any terms and conditions of this Agreement expressly providing for the termination of such licenses), non-exclusive license, under Infinity Intellectual Property, to use Analogs and [**] Information in the discovery of Hits to Amgen
Targets, performing Hit-to-Lead Chemistry Programs and Lead Optimization Programs and in the Development of Royalty-Bearing Products [**]. Subject to Section 3.3, the licenses set forth in this Section 3.1.2 shall further include the
unrestricted right to grant sublicenses. 
 3.1.3 License Limitation and Clarification.  
 (a) For the avoidance of doubt, the purpose of the licenses granted in Sections 3.1.1 and 3.1.2 with respect to Synthetic Methodology and Pathways
is to perform Hit-to-Lead Chemistry Programs and Lead Optimization Programs and in the Development of Royalty-Bearing Products that contain Program Compounds [**], and not to enable Amgen to use Synthetic Methodology and Pathways broadly to
duplicate all or substantially all of Infinity’s libraries of Library Compounds delivered to Amgen for purpose of conducting primary screening. 
 (b) The Parties understand, agree and hereby acknowledge that, to the extent permitted by the other provisions of this Agreement, Amgen will and shall have [**] to include all [**] and [**] and [**] and [**],
including, without limitation, [**] and [**] (provided, however, that for the avoidance of doubt, [**]. 
 3.1.4 [**]
License With Respect to [**]. Infinity hereby grants to Amgen a worldwide, [**] license, under Infinity Intellectual Property, to [**] in [**] for any purposes. Any [**] containing [**] shall be treated as [**] under this Agreement. Such license
shall [**] subject to any terms and conditions of this Agreement expressly providing [**] of such license. Subject to Section 3.3, the licenses set forth in this Section 3.1.4 shall further include the [**]. 
 3.1.5 [**] Licenses With Respect to [**]. Infinity hereby grants to Amgen a worldwide, [**] (subject to any terms and conditions of this Agreement
expressly providing [**] of such license), [**] license, under Infinity Intellectual Property that [**] and [**] to [**] as [**] and as [**], as the case may be. Subject to Section 3.3, the licenses set forth in this Section 3.1.5 shall
further include the [**]. 
 Section 3.2 LIMITED AMGEN GRANT. If in the course of using Library Compounds, Analogs or Know-How
related thereto Amgen makes an invention which results in the filing of Patent Rights, Amgen hereby grants to Infinity a [**]. Such Amgen license is [**] including, without limitation, [**]. Such license [**]. 

  

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Subject to [**]. 
 Section 3.3
SUBLICENSE RIGHTS. Wherever in this Agreement either Party is granted the right to grant sublicenses (including granting to sublicensees the right to grant further sublicenses for the purposes of having Library Compounds and Analogs made)
subject to this Section 3.3, such Party may exercise such right without obtaining the prior approval of the other Party, provided that such sublicense occurs pursuant to a written agreement that subjects such sublicensee to all relevant
restrictions and limitations in this Agreement; and provided, further, that, except with respect to sublicenses granted with respect to [**], Amgen shall promptly notify Infinity of the identity of any Third Party sublicensee. Except
as otherwise agreed to by the Parties in writing, each Party shall be jointly and severally responsible with its sublicensees to the other Party for failure by its sublicensees to comply with, and each Party guarantees the compliance by each of its
sublicensees with, all such applicable restrictions and limitations in accordance with the terms and conditions of this Agreement. 
 Section 3.4 SECTION 365(N) OF THE BANKRUPTCY CODE. All rights and licenses granted under or pursuant to any section of this Agreement are, and shall otherwise be deemed to be, for purposes of Section 365(n) of Title 11 of
the United States Code, as amended (such Title 11, the “Bankruptcy Code”), licenses of rights to “intellectual property” as defined under Section 101(35A) of the Bankruptcy Code. The Parties shall retain and may fully
exercise all of their respective rights and elections under the Bankruptcy Code. 
 Section 3.5 NO IMPLIED LICENSES OR RIGHTS.
Except as expressly provided in this Agreement, neither Party shall have any license or other interest in any intellectual property rights Controlled by the other Party. 
 Section 3.6 [**]. 
 3.6.1 [**]. 
 (a) [**] in accordance with this Section 3.6.1 with respect to each Library Compound that has been
identified as a Hit (or is structurally related to a Hit) which Amgen selects to move forward in a Drug Discovery Program. In the event that [**] with respect to a [**], Amgen shall give Infinity written notice of such desire [**], which notice
shall specify the [**] with respect to which [**]. 
 (b) Within [**] Business Days after receiving Amgen’s notice, Infinity
shall notify Amgen of whether, prior to the date of receipt of Amgen’s notice, (i) [**] and[**], (ii) Infinity [**] directed to the same [**] requested by Amgen and Infinity is [**] either [**] or [**] or (iii) Infinity has [**]
that specifically claims the [**] requested by Amgen and has [**] therefor. If any of the conditions described in clauses (i), (ii) or (iii) of the immediately preceding sentence exist, then Amgen [**] the [**] with respect to such [**];
provided that if the [**] after [**], Infinity shall promptly notify Amgen in writing of [**] and Amgen shall thereupon have [**] with respect to such [**] in accordance with this Section 3.6.1. In the event that none of the
conditions described in clauses (i), (ii) or (iii) of this Section 3.6.1(b) exist, then Infinity shall disclose to Amgen a [**] in relation to the [**]requested by Amgen and a [**]. 
  

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 (c) If Infinity does not notify Amgen that such [**] is [**] in accordance with
Section 3.6.1(b) within [**] Business Days after Amgen delivered its notice to Infinity, then Amgen shall have [**] Business Days following such [**] day period to [**] with respect to such [**] by [**], if any, shall be designated the
“[**]”). During the [**] or [**] day periods described in this Section 3.6.1(c), Infinity shall not [**] or otherwise [**], including without limitation, [**] and [**]. 
 3.6.2 [**]. In connection with [**], Amgen shall be entitled to elect up to [**], each of which must be available in accordance with the criteria
for availability set forth in Section 3.6.1(b), for [**] set forth in Section 3.6.1(c). Amgen may [**] either at the time, or on any single day prior to the [**]. To the extent that any of the [**] Amgen elects are not available in
accordance with the criteria for availability set forth in Section 3.6.1(b), Amgen shall have the right to [**] until such time as it has [**]. Amgen may also, at the time, or on the [**], of Amgen’s [**], elect [**] to the extent
available in accordance with the criteria for availability set forth in Section 3.6.1(b), provided that Amgen shall [**]. The Parties shall document in writing Amgen’s [**] in connection with [**] of the [**]. 
 3.6.3 Infinity Covenant Regarding [**]. In addition to the license granted by Infinity to Amgen set forth in Section 3.1.4 with respect to
[**], Infinity hereby covenants that from and after Amgen’s [**] with respect to [**], Infinity shall [**] such [**] from all [**] by Infinity to [**] and shall not [**] or[**] to [**] with respect to [**] set forth in Section 3.1.4 with
respect to such [**] remains in effect. Infinity further agrees and covenants that Infinity shall not use Amgen Confidential Information to make, use or otherwise conduct any research or development with [**] or [**] from [**]. 
 3.6.4 Termination of Certain License Rights. Upon Amgen’s [**] with respect to [**], the license granted by Amgen to Infinity in
Section 3.2 shall terminate with respect to such [**]. 
 ARTICLE 4 
 FINANCIAL PROVISIONS 
 Section 4.1 CONTINUATION FEE. On or before
the [**] Business Day after the Effective Date, Amgen shall pay to Infinity a one-time, non-refundable license fee of Two Million Five Hundred Thousand Dollars ($2,500,000). 
 Section 4.2 [Omitted] 
 Section 4.3 MILESTONE PAYMENTS. 
 4.3.1 Royalty-Bearing Products. Amgen shall pay Infinity the following amounts
within [**] days after the first achievement by Amgen, its Affiliates or its sublicensees of the corresponding milestone events with respect to each Royalty-Bearing Product. Each payment under this Section 4.3.1 shall be made only once per
Amgen Target, for the first Royalty-Bearing 

  

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Product Developed against such Amgen Target for which such milestone event is achieved and only once per Royalty-Bearing Product regardless of the number of
times a milestone event is achieved for the same Royalty-Bearing Product. The Parties recognize that a single Royalty-Bearing Product may modulate more than one Amgen Target. For the avoidance of doubt, in the event that a single Royalty-Bearing
Product modulates more than one Amgen Target, (1) each payment under this Section 4.3.1 shall still be made only once with respect to such Royalty-Bearing Product, (2) Amgen shall identify to Infinity the coded identifier for a single
Amgen Target against which such Royalty-Bearing Product shall be considered Developed, and (3) each other Amgen Target which such Royalty-Bearing Product modulates shall be available for payments pursuant to this Section 4.3.1 if a
Royalty-Bearing Product containing a different Program Compound is Developed by Amgen to modulate such other Amgen Target. 
  

			
	 Milestone
	  	 Payment

	 (a) [**]
	  	 $[**]

	 (b) [**]
	  	 $[**]

	 (c) [**]
	  	 $[**]

	 (d) [**]
	  	 $[**]

	 (e) [**]
	  	 $[**]

	 (f) [**]
	  	 $[**]

	 (g) [**]
	  	 $[**]

 4.3.2 Additional Payments for Milestone Events Achieved by [**]. In the event that
the Royalty-Bearing Product that triggers milestone payments under Section 4.3.1 is an [**], Amgen shall pay Infinity the following amounts concurrently with the corresponding milestone payment made under Section 4.3.1. Each payment under
this Section 4.3.2 shall be made only once per Amgen Target, for the [**] such Amgen Target for which such milestone event is achieved and [**] regardless of the [**] for the [**]. The Parties recognize that a single [**] Amgen Target. For the
avoidance of doubt, in the event that a [**] Amgen Target, (1) each payment under this Section 4.3.2 shall still be made [**], (2) Amgen shall identify to Infinity the coded identifier for a [**] Amgen [**], and (3) each other
Amgen Target which such [**] for payments pursuant to this Section 4.3.2 if an [**] to modulate such other Amgen Target. 
  

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	 Milestone
	  	 Payment

	 (a) [**]
	  	 $[**]

	 (b) [**]
	  	 $[**]

	 (c) [**]
	  	 $[**]

	 (d) [**]
	  	 $[**]

	 (e) [**]
	  	 $[**]

 4.3.3 Notices; Clarifications. Amgen shall promptly notify Infinity of each milestone event
for which a milestone payment is due. Such milestone payments shall be non-refundable and shall not be credited against royalties payable to Infinity under this Agreement. If any milestone set forth above with respect to a specific jurisdiction is
achieved prior to or in the absence of the achievement of any preceding milestone in the same jurisdiction with respect to an Amgen Target, then, effective upon achievement of any such later milestone, [**]. Similarly, if the First Commercial Sale
of a Royalty-Bearing Product that has been Developed against an Amgen Target occurs prior to or in the absence of the achievement of any milestone with respect to such Amgen Target, then, effective upon such First Commercial Sale, [**]. For the
avoidance of doubt, in the event that Amgen obtains rights to a Program Compound from a Third Party licensee of Infinity, Infinity shall not be entitled to receive milestone or other payments under this Agreement in respect thereof and in the event
that Amgen grants rights to a Program Compound to a licensee of Infinity, any milestone or other payments that Amgen shall be obligated to pay Infinity hereunder shall exhaust Infinity’s rights to receive payments from such licensee under the
agreement between Infinity and such licensee. 
 Section 4.4 SUCCESS PAYMENTS. Amgen shall pay Infinity success payments for
achievements attained by Amgen, its Affiliates or its Sublicensees, in the course of or in relation to a Drug Discovery Program, with respect to Library Compounds or Program Compounds, as follows: 
 4.4.1 [**]. Amgen shall pay to Infinity a one-time payment of $[**] within [**] days after the [**]: 
 (a) Initiation by Amgen of [**]; 
 (b) Initiation by Amgen of [**]; or 
 (c) [**] 
 4.4.2 [**]. Amgen shall pay to Infinity a one-time payment of $[**] within [**] days after the [**] described in Exhibit B during the
Combined Term, but after the [**]. 
  

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 4.4.3 Notices; Clarification. Amgen shall promptly notify Infinity of each event giving rise to
Amgen’s obligations to pay the First Success Payment and the Second Success Payment. Such success payments shall be non-refundable and shall not be credited against royalties payable to Infinity under this Agreement. 
 Section 4.5 ROYALTIES. 
 4.5.1 Royalties if [**]. 
 (a) Amgen shall pay to Infinity royalties on aggregate annual Net Sales of each
Royalty-Bearing Product in the Territory, on a Royalty-Bearing Product-by-Royalty-Bearing Product basis, at the following rates: 
 (i)
If aggregate annual Net Sales of such Royalty-Bearing Product for a given calendar year are less than $[**], [**] percent ([**]%) of all Net Sales of such Royalty-Bearing Product for such calendar year; 
 (ii) If aggregate annual Net Sales of such Royalty-Bearing Product for a given calendar year are at least $[**] but less than $[**], [**] percent
([**]%) of all Net Sales of such Royalty-Bearing Product for such calendar year; and 
 (iii) If aggregate annual Net Sales of such
Royalty-Bearing Product for a given calendar year are $[**] or greater, [**] percent ([**]%) of all Net Sales of such Royalty-Bearing Product for such calendar year. 
 (b) In addition to the royalties payable under Section 4.5.1(a) above, Amgen shall pay to Infinity an additional royalty of [**] percent ([**]%) of Net Sales on all Net Sales of [**]. 
 (c) With respect to each country in the Territory, Royalties shall be payable on the Net Sales of each Royalty-Bearing Product during the [**]
period commencing on the First Commercial Sale of such Royalty-Bearing Product in such country (each, a “Royalty Term”). 
 (d)
If any royalties or other payments are due to Third Parties, whether directly by Amgen or indirectly, which payments are reasonably necessary for Amgen to avoid a claim of infringement of any composition of matter or method of manufacture claims
of any Patents Rights of such Third Parties due to the identification, development, manufacture, use or sale of a Royalty-Bearing Product(s) (such payments, “Amgen Third Party Payments”), then Amgen shall be responsible for payment of all
such payments, provided, however, that Amgen [**] Amgen [**] royalties to Infinity, provided, further, that such [**] shall be limited to the extent that [**] Amgen [**] Infinity [**] or (ii) the [**]
with respect to [**] Infinity with respect to Section 4.5.1(a). [**] pursuant to the final clause [**]. 
 (e) Upon the
expiration of the Royalty Term with respect to any country in the Territory, Infinity shall be deemed to have granted (and hereby grants to Amgen) a fully paid-up, irrevocable, perpetual license, including the unrestricted right to grant
sublicenses, to make, use, sell, offer to sell and import (and have any of the foregoing done for Amgen) the Royalty-Bearing Products within such country. 
  

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 4.5.2 [**]. For each [**] that is the subject of a [**], at any time prior to the [**], Amgen may
[**] Infinity (and Amgen’s obligations under Section [**]) with respect to [**] (and all [**] thereto, provided that Amgen has [**] Infinity of [**] Infinity, [**]. 
 4.5.3 Non Royalty-Bearing Products. Amgen shall have no obligation to pay milestones, royalties or any other payment to Infinity in respect of Non
Royalty-Bearing Products. 
 Section 4.6 ROYALTY REPORTS; PAYMENTS. Within [**] days after the end of each calendar quarter,
Amgen shall submit to Infinity a report, on the basis of each Royalty-Bearing Product (other than Royalty-Bearing Products for which Amgen has eliminated its royalty obligations pursuant to Section 4.5.2), providing in reasonable detail an
accounting of all Net Sales made during such calendar quarter. Concurrently with each such report, Amgen shall pay to Infinity all royalties payable by it under Section 4.5, as follows: (a) Amgen shall make estimated royalty payments with
each such report submitted with respect to any of the first three calendar quarters of any calendar year based on the lowest royalty tier set forth in Section 4.5.1(a) (taking into consideration Section 4.5.1(d), if applicable) into
which Amgen’s aggregate annual Net Sales of each Royalty-Bearing Product for such year could fall based on year-to-date Net Sales of such Royalty-Bearing Product and (b) Amgen shall make royalty payments with each such report submitted
with respect to the final calendar quarter of any calendar year based on the actual royalty tier set forth in Section 4.5.1(a) (taking into consideration Section 4.5.1(d), if applicable) into which Amgen’s aggregate annual Net Sales
of each Royalty-Bearing Product for such year actually fell and include with such royalty payments any additional amounts necessary to make the total of all royalty amounts paid by Amgen with respect to all Net Sales of Royalty-Bearing Products for
such calendar year correct based on the actual royalty tiers set forth in Section 4.5.1(a) (taking into consideration Section 4.5.1(d), if applicable) into which Amgen’s aggregate annual Net Sales of such Royalty-Bearing Products for
such year actually fell. 
 Section 4.7 AUDITS. Amgen shall keep complete and accurate records of the underlying revenue and
expense data relating to the calculations of Net Sales and payments required by Section 4.6. Infinity shall have the right, once annually at its own expense, to have an independent, certified public accountant, selected by Infinity and
reasonably acceptable to Amgen, review any such records of Amgen in the location(s) where such records are maintained by Amgen upon reasonable notice (which shall be no less than thirty (30) days prior written notice) and during regular
business hours and under obligations of strict confidence, for the sole purpose of verifying the basis and accuracy of payments made under Section 4.6 within the prior [**] period; provided however, that the books and records for
any particular calendar year shall only be subject to one audit. The report of such accountant shall be limited to a certificate stating whether any report made or payment submitted by Amgen during such period is accurate or inaccurate and the
amount of any payment discrepancy. Amgen shall receive a copy of each such report concurrently with receipt by Infinity. Should such inspection lead to the discovery of a discrepancy to Infinity’s detriment in an annual period, Amgen shall pay
the amount of the discrepancy. Infinity shall pay the full cost of the inspection unless the 

  

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discrepancy is greater than [**] to Infinity’s detriment, in which case Amgen shall pay the reasonable cost charged by such accountant for such
inspection. Upon the expiration of [**] years following the end of any calendar year, the calculation of royalties payable with respect to such year shall be binding and conclusive upon Infinity; Amgen, its Affiliate(s) and sublicensee(s) shall be
released from any liability or accountability with respect to royalties for such year; and Amgen shall no longer be required to retain such records for such calendar year. 
 Section 4.8 TAX MATTERS. 
 4.8.1 Taxes. All excises, taxes, and duties (collectively “Taxes”) levied on account of payments made by Amgen to Infinity pursuant to this Agreement will be the responsibility of and paid by Infinity or
subject to the withholding, remittance, and offset provisions of this Section 4.8 as provided herein. 
 4.8.2 Character of
Payments. The Parties agree that, for purposes of determining the applicability of any Taxes, the payments to be made under Sections 3.6.1, 3.6.2, 4.3, 4.4 and 4.5 constitute royalties. However, in the event that the governing tax authority
recharacterizes any such payment, any additional Taxes that may be imposed (including any interest and penalties that may be imposed thereon) shall be the responsibility of Infinity, and Amgen shall have a right of offset with respect to such
amounts pursuant to Section 4.8.4. 
 4.8.3 Withholding or Payment by Amgen. In the event that laws or regulations require
withholding of Taxes on behalf of Infinity from any payment owed by Amgen hereunder, such Taxes will be deducted from such payment by Amgen and will be remitted by Amgen on behalf of Infinity to the appropriate tax authority. Amgen will furnish
Infinity with proof of payment of such Taxes as soon as practicable after such payment is made. In the event that documentation is necessary in order for Infinity to secure an exemption from or a reduction in any withholding of Taxes, Infinity shall
provide such documentation in a timely manner to Amgen. The Parties will reasonably cooperate in completing and filing documents required under the provisions of any applicable tax Laws or under any other applicable Law in connection with the making
of any required tax payment or withholding payment, or in connection with any claim to a refund of or credit for any such payment. 
 4.8.4 Amgen’s Right of Offset. In the event that the governing tax authority retroactively determines that a payment made to Infinity pursuant to this Agreement should have been subject to withholding (or to additional
withholding) for Taxes, Amgen shall promptly notify Infinity thereof in writing, Infinity shall have the right to contest such determination at Infinity’s expense and Amgen will reasonably cooperate with Infinity if it so contests the
determination. Amgen will have the right to offset the withholding amount which it pays consistent with such tax authority’s determination (including any interest and penalties that may be imposed thereon) against future payment obligations of
Amgen under this Agreement; provided, however, that if no further payments or insufficient further payments are available against which offset may be pursued, Amgen may pursue reimbursement by any remedy (at law or in equity)
available to it. In no event shall Infinity have any liability for interest or penalties imposed as a result of Amgen’s failure to withhold Taxes but only if such failure was due to Amgen’s negligence. 
  

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 Section 4.9 UNITED STATES DOLLARS. All dollar ($) amounts specified in this Agreement
are United States dollar amounts. 
 Section 4.10 CURRENCY EXCHANGE. With respect to Net Sales invoiced or expenses incurred in
U.S. dollars, the Net Sales or expense amounts and the amounts due to the receiving Party hereunder shall be expressed in U.S. dollars. Net Sales invoiced in currencies other than U.S. dollars shall be converted into the U.S. dollar equivalent using
an average rate of exchange which corresponds to the amount recorded by Amgen related to such Net Sales in its books and records that are maintained in accordance with GAAP. All payments shall be made in U.S. dollars. If at any time legal
restrictions in any country in the Territory prevent the prompt remittance of any payments with respect to sales in that country, Amgen shall make such payments by depositing the amount thereof in local currency to Infinity’s account in a bank
or depository in such country. 
 Section 4.11 LATE PAYMENTS. The paying Party shall pay interest to the receiving Party on the
aggregate amount of any payments that are not paid on or before the date such payments are due under this Agreement at a rate per annum equal to [**], as reported by The Wall Street Journal, or the highest rate permitted by applicable Law,
calculated on the number of days such payments are paid after the date such payments are due; provided, however, that, with respect to any disputed payments, no interest payment shall be due until such dispute is resolved and
the interest which shall be payable thereon shall be based on the finally-resolved amount of such payment, calculated from the original date on which the disputed payment was due through the date on which payment is actually made. 
 ARTICLE 5 
 INTELLECTUAL PROPERTY
OWNERSHIP, PROTECTION AND RELATED 
 MATTERS 
 Section 5.1 OWNERSHIP. 
 5.1.1 Inventorship. Inventorship of inventions conceived or
reduced to practice during the course of the performance of activities pursuant to the Prior Agreement or this Agreement shall be determined in accordance with the applicable U.S. patent Laws. 
 5.1.2 Ownership. All inventions or discoveries made, and materials (including without limitation, Library Compounds and Analogs) and information
created, by employees, Affiliates, agents, independent contractors or consultants of each Party, in the course of conducting activities under the Prior Agreement or this Agreement, together with all intellectual property rights therein, shall be
owned by the Party or Parties to which such employees, Affiliates, agents, independent contractors or consultants have an obligation to assign such inventions or discoveries. Subject to the provisions of Article 3, Amgen shall own all rights, title
and interest in all [**], but specifically excluding any Infinity Patent Right which has been generated without the use of Amgen Confidential Information. 
  

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 5.1.3 Prosecution and Maintenance of Patent Rights. 
 (a) The responsibility for (i) preparing, filing and prosecuting patent applications (including, but not limited to, provisional, reissue,
continuing, continuation, continuation-in-part, divisional, and substitute applications and any foreign counterparts thereof); (ii) maintaining any Patent Rights; and (iii) managing any interference or opposition or similar proceedings
relating to the foregoing ((i) through (iii), “Patent Prosecution”) shall (A) with respect to Patent Rights for which the employees, consultants or agents of both Parties are inventors, rest with Amgen (in which case Infinity shall
provide any reasonable cooperation requested by Amgen with respect to such Patent Prosecution) and (B) with respect to [**] and [**], rest with [**] with respect to such Patent Prosecution), and (C) otherwise, rest with the owning Party.

 (b) All Patent Prosecution expenses, including attorneys’ fees, incurred by a Party in the performance of Patent Prosecution
shall be borne by such Party. 
 (c) Amgen shall use commercially reasonable efforts to avoid claiming specific Library Compounds
(other than [**] in any patent application filed by Amgen. 
 (d) In the event that, in spite of Amgen’s efforts pursuant to
Section 5.1.3(c), any Infinity employee(s) or contractor(s) is named as an inventor on any patent application filed by Amgen claiming an [**] or [**] Information, Infinity agrees to (and does hereby) assign all its rights, title and interest in
and to such patent application(s) (and any patent(s) that issues therefrom) to Amgen. 
 5.1.4 Omitted. 
 5.1.5 Omitted. 
 Section 5.2 THIRD PARTY INFRINGEMENT. 
 5.2.1 Notice. Each Party shall promptly provide the other Party with
written notice reasonably detailing any known or alleged infringement by a Third Party of Infinity Patent Rights or Patent Rights owned or otherwise controlled by Amgen that claim the composition of matter of any [**]. 
 5.2.2 Enforcement. Amgen shall have the sole right, but not the obligation, to institute and direct legal proceedings against any Third Party
believed to be infringing claims of Infinity Patent Rights that cover the [**], including, but not limited to those that claim the composition of matter, method of making, use and pharmaceutical composition of any [**], by the manufacture, use,
importation, offer for sale or sale of a product competitive with a Royalty-Bearing Product; provided that such right shall only continue for so long as the license granted to Amgen with respect to such [**] remains in effect. All costs,
including attorneys’ fees, relating to such legal proceedings shall be borne by Amgen, and Amgen shall reimburse Infinity for any such costs incurred by Infinity. All recoveries resulting from such legal proceedings that are in excess of the
Parties’ costs of bringing or participating in such action, including attorney’s fees, shall be retained by Amgen and shall be deemed to constitute Net Sales of the Royalty-Bearing Product with which the infringing Third Party product
competed. 
  

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 5.2.3 Cooperation In Patent Infringement Proceedings. In the event that Amgen takes action
pursuant to this Section 5.2, Infinity shall cooperate to the extent reasonably necessary and at Amgen’s sole expense. Upon the reasonable request of Amgen, Infinity shall join the suit and shall have the right to be represented in any
such legal proceedings using counsel of its own choice, at Amgen’s expense. Amgen shall not settle any claim or proceeding relating to any Infinity Patent Rights with respect to which Amgen takes action pursuant to this Section 5.2 without
the prior written consent of Infinity, which consent shall not be unreasonably withheld or delayed. 
 5.2.4 Amgen Independent
Compounds. For the avoidance of doubt and notwithstanding any other provision of this Agreement, if Amgen, prior to the discovery of a Hit by screening the Library Compounds, through in-licensing or acquisition (merger or otherwise) from a Third
Party(ies), or research efforts that are entirely independent of efforts under a Drug Discovery Program and without the use or assistance of any Confidential Information of Infinity (as shown by Amgen’s independent, contemporaneous written
records), shall have discovered a compound that shall be structurally identical to a Library Compound or Analog and known to have activity against the Amgen Target (“Amgen Independent Compounds”), then such Amgen Independent Compound(s)
shall not be considered a Library Compound or an Analog or a Royalty-Bearing Product. Amgen shall be free to develop and commercialize such Amgen Independent Compounds without any obligation whatsoever to Infinity, provided, that Amgen
does not utilize any Confidential Information of Infinity in connection with such development and commercialization efforts. In the event that Amgen identifies any Amgen Independent Compounds, Amgen shall promptly provide written notice to Infinity
that such Amgen Independent Compound(s) has been discovered and shall stop using the relevant Library Compound and the related Library Compound Information received from Infinity. 
 ARTICLE 6 
 CONFIDENTIALITY 
 Section 6.1 CONFIDENTIAL INFORMATION. All Confidential Information of a Party shall not be used by the other Party (the “Bound
Party”) except in performing its obligations or exercising rights explicitly granted under this Agreement and shall be maintained in confidence by the Bound Party and shall not otherwise be disclosed by the Bound Party to any Third Party,
without the prior written consent of the Party that Controls such Confidential Information (the “Controlling Party”), except to the extent that the Confidential Information: 
 6.1.1 was known by the Bound Party or its Affiliates prior to its date of disclosure to the Bound Party; or 
 6.1.2 is lawfully disclosed to the Bound Party or its Affiliates by sources other than the Controlling Party rightfully in possession of the
Confidential Information; or 
 6.1.3 becomes published or generally known to the public through no fault or omission on the part of
the Bound Party, its Affiliates or its sublicensees; or 
  

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 6.1.4 is independently developed by or for the Bound Party or its Affiliates without reference to
or reliance upon such Confidential Information. 
 Specific information shall not be deemed to be within any of the foregoing exclusions
merely because it is embraced by more general information falling within those exclusions. 
 Section 6.2 PERMITTED DISCLOSURE.

 6.2.1 The provisions of Section 6.1 shall not preclude (a) a Bound Party or its Affiliates from disclosing Confidential
Information to the extent such Confidential Information is required to be disclosed by such Party or its Affiliates to comply with applicable Laws or legal process, including without limitation the rules or regulations of the United States
Securities and Exchange Commission or similar regulatory agency in a country other than the United States or of any stock exchange, including without limitation Nasdaq, or to defend or prosecute litigation, provided that such Party
provides prior written notice of such disclosure to the disclosing Party and takes reasonable and lawful actions to avoid and/or minimize the degree of such disclosure and (b) Amgen from disclosing and/or claiming Infinity’s Confidential
Information (including, without limitation, chemical structures and methods of making such chemical structures) in Amgen’s patent applications and in the prosecution of such patent applications consistent with the terms and conditions of
Article 5 above. 
 6.2.2 Subject to Sections 6.2.3 and 9.9, the Parties agree that the material financial terms of the Prior
Agreement or this Agreement will be considered Confidential Information of both Parties. Notwithstanding the foregoing, (a) either Party may disclose the terms of this Agreement to bona fide potential or actual sublicensees, as reasonably
necessary in connection with a permitted sublicense under the licenses granted in this Agreement, and (b) either Party may disclose the material financial terms of this Agreement to bona fide potential or actual investors, lenders, investment
bankers, acquirors, acquirees, merger partners or other potential financial partners (including pharmaceutical and biotechnology companies, as long as such company owns at least fifty percent (50%) of the disclosing Party), and to such
Party’s consultants and advisors, as reasonably necessary in connection with a proposed equity or debt financing of such Party or as reasonably necessary in connection with a proposed acquisition or business combination. In connection with any
permitted disclosure of Confidential Information pursuant to this Section 6.2.2, each Party agrees to use all reasonable efforts to inform each disclosee of the confidential nature of such information and cause each disclosee to treat such
information as confidential. 
 6.2.3 Notwithstanding any provision to the contrary in this Agreement, either Party may disclose to
any and all persons, without limitation of any kind, the United States federal tax treatment and tax structure of the transactions set forth in this Agreement and all materials of any kind (including opinions or other tax analyses) that are provided
to the Parties relating to such tax treatment and tax structure. 
 6.2.4 In no event will Infinity use the [**] as a basis for a
decision to advance (or not advance) any research or discovery program outside the scope of this Agreement by Infinity itself or in collaboration with any Third Party; [**]. 

  

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 Section 6.3 EMPLOYEE AND ADVISOR OBLIGATIONS. Infinity and Amgen each agree that they shall
provide Confidential Information that is jointly owned or received from the other Party only to their respective employees, consultants and advisors, and to the employees, consultants and advisors of such Party’s Affiliates, who have a need to
know such information and materials for performing obligations or exercising rights expressly granted under this Agreement and have an obligation to treat such information and materials as confidential. 
 Section 6.4 TERM. All obligations under this Article 6 shall expire five (5) years following termination or expiration of this
Agreement. 
 Section 6.5 PUBLICATIONS. Neither Amgen nor its Affiliates, employees, contractors or investigators shall publish
or present any information with respect to the structure of any Library Compound, other than any [**], without Infinity’s prior written consent (which may be withheld in its sole and final discretion). 
 ARTICLE 7 
 TERM AND TERMINATION

 Section 7.1 AGREEMENT TERM. This Agreement becomes effective as of the Effective Date and shall expire upon the earlier of
(a) the termination of this Agreement in accordance with Sections 7.2 or 7.3, or (b) the later of (i) the permanent cessation by Amgen of all research and Development activities with respect to all Library Compounds and Program
Compounds or (ii) the expiration of the last Royalty Term with respect to all Royalty-Bearing Products. 
 Section 7.2
TERMINATION FOR CONVENIENCE. Amgen shall have the right to terminate this Agreement for convenience upon sixty (60) days prior written notice to Infinity. 
 Section 7.3 TERMINATION FOR MATERIAL BREACH. If either Party believes that the other is in material breach of this Agreement (including without limitation any material breach of a representation or
warranty made in this Agreement), then the non-breaching Party may deliver notice of such breach to the allegedly breaching Party. In such notice the non-breaching Party shall identify the actions or conduct that such Party would consider to be an
acceptable cure of such breach. For all breaches, the allegedly breaching Party shall have sixty (60) days to either cure such breach or, if cure cannot be reasonably effected within such sixty (60) day period, to deliver to the other
Party a plan for curing such breach that is reasonably sufficient to effect a cure. Such a plan shall set forth a program for achieving cure as rapidly as practicable. Following delivery of such plan, the allegedly breaching Party shall use diligent
efforts to carry out the plan and cure the breach. If the allegedly breaching Party fails to cure such breach within the sixty (60) day period, the non-breaching Party may terminate this Agreement upon written notice to the allegedly breaching
Party. 
  

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 Section 7.4 EFFECT OF TERMINATION; ACCRUED RIGHTS; SURVIVING OBLIGATIONS. 
 7.4.1 Upon termination of this Agreement by Amgen pursuant to Section 7.2, (a) all licenses granted by Infinity to Amgen hereunder shall
terminate, and (b) all licenses granted hereunder by Amgen to Infinity shall remain in effect on an irrevocable and perpetual basis. 
 7.4.2 Upon termination of this Agreement by Amgen pursuant to Section 7.3, (a) all licenses granted by Infinity to Amgen hereunder shall remain in effect in accordance with the terms and conditions set forth in the grant,
(b) all licenses granted hereunder by Amgen to Infinity shall remain in effect in accordance with the terms and conditions set forth in the grant, and (c) all payment obligations of Amgen hereunder shall remain in effect, subject to the
right for Amgen to offset, prior to and until the determination of actual damages pursuant to Section 7.4.4, against any payment obligations set forth in this Agreement such amounts as reasonably reflect the nature, circumstances and
significance of the breach leading to such termination and the damages, if any, suffered by Amgen and provided that, to the extent that any such offsets actually taken exceed the actual damages to which Amgen is ultimately determined
to be entitled, Amgen shall reimburse Infinity for such excess offsets, along with interest earned thereon at the rate of the lesser of [**] percent ([**]%) per year or the highest rate permitted by applicable law. 
 7.4.3 Upon termination of this Agreement by Infinity pursuant to Section 7.3, (a) all licenses granted hereunder by Amgen to Infinity
shall remain in effect in accordance with the terms and conditions set forth in the grant, (b) all licenses granted by Infinity to Amgen hereunder shall remain in effect in accordance with the terms and conditions set forth in the grant, and
(c) all payment obligations of Amgen hereunder shall remain in effect. 
 7.4.4 For the sake of clarity, each Party shall have
the right to seek any damages to which it is entitled, whether in law, equity or otherwise. 
 7.4.5 Upon the termination or the
expiration of this Agreement, the following provisions of this Agreement shall survive: Articles 1, 6 and 9, and Sections 2.2, 3.3 (to the extent that any licenses subject to Section 3.3 survive), 3.4, 4.6, 4.7, 4.8, 4.9, 4.10, 4.11, 5.1 and
8.7 and this Section 7.4. 
 7.4.6 Termination or expiration of the Agreement for any reason, and any benefit accruing to Amgen
from any reduction in payments pursuant to Section 7.4.2(c), shall be without prejudice to any rights that shall have accrued to the benefit of either Party prior to such termination or expiration, including, without limitation, any other
remedies available to such Party in law or equity. Such termination or expiration shall not relieve either Party from obligations that are expressly indicated to survive termination or expiration of the Agreement. 
 ARTICLE 8 
 REPRESENTATIONS,
WARRANTIES AND COVENANTS 
 Section 8.1 REPRESENTATION OF AUTHORITY; CONSENTS. Infinity and Amgen each represents and
warrants to the other Party that, as of the Effective Date, (a) it has 

  

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full right, power and authority to enter into this Agreement, (b) this Agreement has been duly executed by such Party and constitutes a legal, valid and
binding obligation of such Party, enforceable in accordance with its terms, except as enforceability may be limited by bankruptcy, fraudulent conveyance, insolvency, reorganization, moratorium and other Laws relating to or affecting creditors’
rights generally and by general equitable principles and public policy constraints (including those pertaining to limitations and/or exclusions of liability, competition Laws, penalties and jurisdictional issues including conflicts of Laws) and
(c) all necessary consents, approvals and authorizations of all government authorities and other persons required to be obtained by such Party in connection with the execution, delivery and performance of this Agreement have been and shall be
obtained. 
 Section 8.2 NO CONFLICT. Each Party represents to the other Party that, notwithstanding anything to the contrary in
this Agreement, the execution and delivery of this Agreement and the performance of such Party’s obligations hereunder (a) do not conflict with or violate such Party’s corporate charter and bylaws or any requirement of applicable Laws
and (b) do not and shall not conflict with, violate or breach or constitute a default or require any consent under, any oral or written contractual obligation of such Party. Each Party agrees that it shall not during the term of this Agreement
grant any right, license, consent or privilege to any Third Party or otherwise undertake any action, either directly or indirectly, that would conflict with the rights granted to the other Party or interfere with any obligations of such Party set
forth in this Agreement. 
 Section 8.3 KNOWLEDGE OF PENDING OR THREATENED LITIGATION. Each Party represents and warrants to the
other Party that there is no claim, investigation, suit, action or proceeding pending or, to the knowledge of such Party, expressly threatened, against such Party that, individually or in the aggregate, could reasonably be expected to
(a) materially impair the ability of such Party to perform any obligation under this Agreement or (b) prevent or materially delay or alter the consummation of any or all of the transactions contemplated hereby. 
 Section 8.4 EMPLOYEE AND CONSULTANT OBLIGATIONS. 
 8.4.1 Each Party represents and warrants that all of its employees, officers, and consultants that are supporting the performance of its obligations under this Agreement shall have executed agreements
requiring, in the case of consultants, employees and officers, assignment to such Party of all inventions made during the course of and as the result of their association with such Party and, in the case of employees, officers and consultants,
obligating the individual to maintain as confidential such Party’s Confidential Information as well as Confidential Information of the other Party that such Party may receive, to the extent required to support such Party’s obligations
under this Agreement. 
 8.4.2 Infinity represents and warrants that it shall use commercially reasonable efforts to maintain its
agreement(s) with any Third Party under which Infinity obtains licenses under rights necessary for its performance under this Agreement which agreement(s) are in effect during the term of this Agreement. As of the Effective Date, to the best of its
knowledge, Infinity does not require any licenses under the Patent Rights or other intellectual property rights of any Third Party to grant the licenses set forth herein. 
  

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 Section 8.5 INTELLECTUAL PROPERTY. Infinity represents and warrants that as of the Effective
Date: 
 8.5.1 it has not received any written claim made against it asserting the non-patentability, invalidity, misuse,
unregisterability, unenforceability or non-infringement of any of intellectual property rights associated with Library Compounds or challenging its right to use or ownership of any of such intellectual property rights or Library Compounds or making
any adverse claim of ownership thereof; and 
 8.5.2 it is not aware of any pending or threatened claim or litigation (or received
notice of a potential claim or litigation) which alleges that its activities up to the Prior Agreement Effective Date relating to Library Compounds have violated, or by conducting the activities currently proposed to be conducted hereunder would
violate, the intellectual property rights or the right to use or ownership of any Third Party. 
 Section 8.6 PRIOR OBLIGATIONS. Amgen
represents and warrants that it has complied with its obligations under Section 2.3.2 of the Prior Agreement. 
 Section 8.7
DISCLAIMER OF WARRANTY. Nothing in this Agreement shall be construed as a representation made or warranty given by either Party that either Party will be successful in obtaining any Patent Rights, that any patents will issue based on pending
applications or that any such pending applications or patents issued thereon will be valid. EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT, EACH PARTY EXPRESSLY DISCLAIMS, WAIVES, RELEASES AND RENOUNCES ANY WARRANTY, EXPRESS OR IMPLIED, INCLUDING,
WITHOUT LIMITATION, ANY WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR NONINFRINGEMENT. 
 ARTICLE 9 
 MISCELLANEOUS PROVISIONS 
 Section 9.1 INDEMNIFICATION. 
 9.1.1 Amgen. Amgen agrees, at Amgen’s cost and expense, to defend, indemnify
and hold harmless Infinity and its Affiliates and their respective directors, officers, employees and agents (the “Infinity Indemnified Parties”) from and against any losses, costs, damages, fees or expenses arising out of any Third Party
claim relating to (a) any breach by Amgen of any of its representations, warranties or obligations pursuant to the Prior Agreement or this Agreement, (b) the gross negligence or willful misconduct of Amgen or (c) injuries resulting
from Amgen’s activities conducted in connection with the Prior Agreement or this Agreement or from the development, manufacture, use, sale or other disposition by Amgen of any product containing a Program Compound, or any other product or
service offered by Amgen, its Affiliates and/or its licensees or collaborators (other than Infinity) outside of activities conducted in connection with the Prior Agreement or this Agreement. In the event of any such claim against the Infinity
Indemnified Parties by any Third Party, Infinity shall promptly notify Amgen in writing of the claim and Amgen shall manage and control, at its sole expense, the defense of the claim and its 

  

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settlement. The Infinity Indemnified Parties shall cooperate with Amgen and may, at their option and expense, be separately represented in any such action or
proceeding. Amgen shall not be liable for any litigation costs or expenses incurred by the Infinity Indemnified Parties without Amgen’s prior written authorization. In addition, Amgen shall not be responsible for the indemnification or defense
of any Infinity Indemnified Party to the extent arising from any negligent or intentional acts by any Infinity Indemnified Party or the breach by Infinity of any obligation or warranty under this Agreement, or any claims compromised or settled
without its prior written consent. 
 9.1.2 Infinity. Infinity agrees, at Infinity’s cost and expense, to defend, indemnify and
hold harmless Amgen and its Affiliates and their respective directors, officers, employees and agents (the “Amgen Indemnified Parties”) from and against any losses, costs, damages, fees or expenses arising out of any Third Party claim
relating to (a) any breach by Infinity of any of its representations, warranties or obligations pursuant to the Prior Agreement or this Agreement, (b) the gross negligence or willful misconduct of Infinity or (c) injuries resulting
from Infinity’s activities conducted in connection with the Prior Agreement or from the development, manufacture, use, sale or other disposition by Infinity of any product containing a Program Compound, or any other product or service offered
by Infinity, its Affiliates and/or its licensees or collaborators (other than Amgen) outside of activities conducted in connection with the Prior Agreement or this Agreement. In the event of any such claim against the Amgen Indemnified Parties by
any Third Party, Amgen shall promptly notify Infinity in writing of the claim and Infinity shall manage and control, at its sole expense, the defense of the claim and its settlement. The Amgen Indemnified Parties shall cooperate with Infinity and
may, at their option and expense, be separately represented in any such action or proceeding. Infinity shall not be liable for any litigation costs or expenses incurred by the Amgen Indemnified Parties without Infinity’s prior written
authorization. In addition, Infinity shall not be responsible for the indemnification or defense of any Amgen Indemnified Party to the extent arising from any negligent or intentional acts by any Amgen Indemnified Party, or the breach by Amgen of
any obligation or warranty under this Agreement, or any claims compromised or settled without its prior written consent. 
 Section 9.2 DISPUTE RESOLUTION. 
 9.2.1 Any controversy, claim or dispute arising out of or relating to this
Agreement shall be settled, if possible, through good faith negotiations between the Parties. If, however, the Parties are unable to settle such dispute after good faith negotiations, the matter shall be referred to the Executive Officers, who shall
attempt to resolve the dispute in good faith. Such resolution, if any, of a referred issue shall be final and binding on the Parties. All negotiations pursuant to this Section 9.2.1 are confidential and shall be treated as compromise and
settlement negotiations for purposes of applicable rules of evidence. For the purposes of this Agreement, “Executive Officers” shall mean the Chief Executive Officer of Infinity and the Vice President, Licensing of Amgen. 
 9.2.2 If the Executive Officers are unable to settle the dispute after good faith negotiation pursuant to Section 9.2.1, then each Party
reserves its right to any and all remedies available under law or equity with respect to such dispute. 
  

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 9.2.3 Notwithstanding anything to the contrary in this Section 9.2, any Party may seek
immediate injunctive or other interim relief from any court of competent jurisdiction as necessary to enforce and prevent infringement or misappropriation of the Patent Rights, Know-How, Confidential Information or other intellectual property rights
Controlled by a Party. 
 Section 9.3 GOVERNING LAW. This Agreement shall be construed and the respective rights of the Parties
determined according to the substantive laws of the State of New York notwithstanding the provisions governing conflicts of law under such New York law to the contrary. 
 Section 9.4 ASSIGNMENT. Neither Infinity nor Amgen may assign this Agreement in whole or in part without the consent of the other, except if such assignment occurs in connection with the sale or transfer
(by merger or otherwise) of all or substantially all of the business and assets of Infinity or Amgen to which the subject matter of this Agreement pertains, and then only if the acquirer confirms to the other Party in writing its agreement to be
bound by all of the terms and conditions of this Agreement. Each Party agrees that, notwithstanding any provisions of this Agreement to the contrary, in the event that this Agreement is assigned by either Party in connection with the sale or
transfer of all or substantially all of the business and assets of such Party to which the subject matter of this Agreement pertains, such assignment shall not provide the non-assigning Party with rights or access to intellectual property or
technology of the acquiror of such Party. Notwithstanding the foregoing, either Party may assign this Agreement to an Affiliate, provided that such Party shall guarantee the performance of such Affiliate. Any purported assignment not
in accordance with this Section 9.4 shall be void and of no effect. 
 Section 9.5 ENTIRE AGREEMENT; AMENDMENTS. The Parties
hereby agree that the Prior Agreement remained in effect commencing on the Prior Agreement Effective Date and continuing until the Effective Date, notwithstanding anything contained in the Prior Agreement to the contrary, including, but not limited
to, the provisions of Sections 2.2 and 7.1 of the Prior Agreement. As of the Effective Date, the Prior Agreement is hereby terminated. On and after the Effective Date, this Agreement and the Exhibits referred to in this Agreement constitute the
entire agreement between the Parties with respect to the subject matter hereof. Any amendment or modification to this Agreement shall be made in writing signed by both Parties. 
 Section 9.6 NOTICES. Notices to Infinity shall be addressed to: 
 Infinity Pharmaceuticals, Inc. 
 780 Memorial Drive 
 Cambridge, Massachusetts 02139 
 Attention: Chief Executive Officer 
 Facsimile No.: (617) 453-1001 
 with a copy to: 
 Wilmer Cutler Pickering Hale and Dorr LLP 
 60 State Street 
 Boston, Massachusetts 02109 
 Attention: Steven D. Singer, Esq. 
 Facsimile No.: (617) 526-5000 
  

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 Notices to Amgen shall be addressed to: 
 Amgen Inc. 
 One Amgen Center Drive 
 Thousand Oaks, CA 91329-1799 
 Attention: Vice President, Licensing 
 Facsimile No.: (805) 499-6056 
 with a copy to: 
 Attention: Senior Vice President, General Counsel 
 Facsimile No.: (805) 499-8011 
 Either Party may change its address to which notices shall be sent by giving notice to the other Party in the manner herein provided. Any notice required or provided for by the terms of this Agreement shall be in writing and shall be
(a) sent by registered or certified mail, return receipt requested, postage prepaid, (b) sent via a reputable overnight courier service, or (c) sent by facsimile transmission, in each case properly addressed in accordance with this
Section 9.6. The effective date of notice shall be the actual date of receipt by the Party receiving the same. 
 Section 9.7
FORCE MAJEURE. No failure or omission by either Party in the performance of any obligation of this Agreement shall be deemed a breach of this Agreement or create any liability if the same shall arise from any cause or causes beyond the
reasonable control of such Party, including, but not limited to, the following: acts of gods; acts of any government; any rules, regulations or orders issued by any governmental authority or by any officer, department, agency or instrumentality
thereof; fire; storm; flood; earthquake; accident; war; rebellion; insurrection; riot; terrorism and invasion; provided that the Party affected by such cause promptly notifies the other Party and uses diligent efforts to cure such
failure or omission as soon as is practicable after the occurrence of one or more of the above mentioned causes. 
 Section 9.8
COMPLIANCE WITH LAWS. Each Party shall perform its obligations under this Agreement in compliance with all applicable Laws. 
 Section 9.9 PUBLIC ANNOUNCEMENTS. Neither Party shall release any information to any Third Party or make any disclosure or public announcement (including but not limited to press releases, educational and scientific conferences,
quarterly investor updates, promotional materials, governmental filings and discussions with public officials, the media, security analysts and investors) regarding the term and existence of this Agreement, or the relationship between the Parties,
without the other Party’s prior written consent; provided, however, that (a) a Party may [**]; and (b), [**], including without limitation 

  

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[**]; the nondisclosing Party shall [**] (provided, however, that the disclosing Party [**]; and (c) Infinity may issue a press
release substantially in the form attached hereto as Exhibit C, the final form of which shall be subject to the Parties’ mutual agreement. 
 Section 9.10 USE OF NAMES, LOGOS OR SYMBOLS. Subject to Section 9.9, no Party hereto shall use the name, trademarks, logos, physical likeness, employee names or owner symbol of any other Party for any
purpose, including, without limitation, private or public securities placements, without the prior written consent of the affected Party. Nothing contained in this Agreement shall be construed as granting either Party any rights or license to use
any of the other Party’s trademarks or trade names or the names of any employees thereof, without separate, express written permission of the owner of such trademark or trade name or name. 
 Section 9.11 INDEPENDENT CONTRACTORS. It is understood and agreed that the relationship between the Parties is that of independent
contractors and that nothing in this Agreement shall be construed to create a joint venture or any relationship of employment, agency or partnership between the Parties to this Agreement. Neither Party is authorized to make any representations,
commitments, or statements of any kind on behalf of the other Party or to take any action that would bind the other Party except as explicitly provided in this Agreement. 
 Section 9.12 NO STRICT CONSTRUCTION. This Agreement has been prepared jointly and shall not be strictly construed against either Party. 
 Section 9.13 HEADINGS. The captions or headings of the sections or other subdivisions hereof are inserted only as a matter of convenience or
for reference and shall have no effect on the meaning of the provisions hereof. 
 Section 9.14 NO IMPLIED WAIVERS; RIGHTS
CUMULATIVE. No failure on the part of Infinity or Amgen to exercise, and no delay by either Party in exercising, any right, power, remedy or privilege under this Agreement, or provided by statute or at law or in equity or otherwise, shall
impair, prejudice or constitute a waiver of any such right, power, remedy or privilege by such Party or be construed as a waiver of any breach of this Agreement or as an acquiescence therein by such Party, nor shall any single or partial exercise of
any such right, power, remedy or privilege by a Party preclude any other or further exercise thereof or the exercise of any other right, power, remedy or privilege. 
 Section 9.15 SEVERABILITY. If, under applicable Laws, any provision of this Agreement is invalid or unenforceable, or otherwise directly or indirectly affects the validity of any other material
provision(s) of this Agreement (such invalid or unenforceable provision, a “Severed Clause”), this Agreement shall endure except for the Severed Clause. The Parties shall consult one another and use good faith efforts to agree upon a valid
and enforceable provision that is a reasonable substitute for the Severed Clause in view of the intent of this Agreement. 
  

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 Section 9.16 EXECUTION IN COUNTERPARTS. This Agreement may be executed in counterparts, each
of which counterparts, when so executed and delivered, shall be deemed to be an original, and all of which counterparts, taken together, shall constitute one and the same instrument. 
 Section 9.17 NO THIRD PARTY BENEFICIARIES. No person or entity other than Amgen and Infinity (and assignees) shall be deemed an intended
beneficiary hereunder or have any right to enforce any obligation of this Agreement. 
 Section 9.18 PERFORMANCE BY AFFILIATES.
To the extent that this Agreement imposes obligations on Affiliates of a Party, such Party agrees to cause its Affiliates to perform such obligations. Either Party may use one or more of its Affiliates to perform its obligations and duties
hereunder, provided that the Parties shall remain liable hereunder for the prompt payment and performance of all their respective obligations hereunder. 
 Section 9.19 NO CONSEQUENTIAL DAMAGES. NEITHER PARTY HERETO WILL BE LIABLE FOR SPECIAL, INCIDENTAL, CONSEQUENTIAL, EXEMPLARY, PUNITIVE OR MULTIPLE DAMAGES ARISING OUT OF THIS AGREEMENT OR THE EXERCISE OF
ITS RIGHTS HEREUNDER, INCLUDING WITHOUT LIMITATION LOST PROFITS ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF SUCH DAMAGES. 
 Section 9.20 Exhibits. In the event of inconsistencies between this Agreement and any exhibits or attachments hereto, the terms of this Agreement shall control. 
 [Remainder of Page Intentionally Left Blank] 
  

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 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the Effective Date. 

 

			
	 INFINITY PHARMACEUTICALS, INC.

		
	 By:
	 	 /s/ Steven H. Holtzman

	 Name:
	 	 Steven H. Holtzman

	 Title:
	 	 Chief Executive Officer

	
	 AMGEN INC.

		
	 By:
	 	 /s/ Roget M. Perlmutter

	 Name:
	 	 Roger M. Perlmutter

	 Title:
	 	 Executive Vice President Research & Development

  

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Contract No. 200315899-002 

 EXHIBIT A 
 Library Compound Delivery Requirements 
  

	1.	The Synthetic Methodology and Pathways information was delivered by Infinity only to the Medicinal Chemistry group at Amgen, or a delegate specified in writing to Infinity (the
recipient group, the “Med Chem Group”), and the Library Compound Structure Information was delivered by Infinity only to the Molecular Structure group at Amgen (the “Molecular Structure Group”). Amgen shall not
disseminate the Synthetic Methodology and Pathways information beyond the Med Chem Group or the Library Compound Structure Information beyond the Molecular Structure Group, provided, however, that Amgen may disseminate such
information related to a Library Compound which is a Hit solely to those Amgen chemists who need such information in order to proceed with a Drug Discovery Program and Amgen shall track which chemists receive such information.

  

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 EXHIBIT B 
 Second Success Triggers 
  

							
	 [**]
	  	[**]	  	[**]	  	[**]
				
	 Then the Second Success Payment may be triggered by:
	  		  		  	
				
		  	[**]	  	[**]	  	[**]
				
		  	[**]	  	[**]	  	[**]
				
		  	[**]	  	[**]	  	[**]

  

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 EXHIBIT C 
 Form of Press Release 
 

 
 INFINITY ANNOUNCES EXTENSION OF AMGEN AGREEMENT 
 CAMBRIDGE, Mass. – July     , 2006 - Infinity Pharmaceuticals Inc. announced today that Amgen Inc. has extended its non-exclusive access
to Infinity’s collection of diverse, natural product-like compounds for drug discovery. Under the terms of the agreement, Amgen has the right to develop drug candidates it has identified from Infinity’s compound collection. Infinity
received an up-front license fee from Amgen and is eligible to receive milestones and royalties based on successful pre-clinical and clinical development and marketing of products resulting from Amgen’s use of Infinity’s compounds.

 Infinity first announced its collaboration with Amgen on January 8, 2004 at which time Amgen made a $25 million equity investment in Infinity. Amgen
currently owns less 10% of the Company. 
 About Infinity’s Diversity Oriented Synthesis 
 Infinity’s proprietary chemistry, Diversity Oriented Synthesis (DOS), allows Infinity to create collections of innovative, diverse, natural product-like compounds
for drug discovery. Through alliances that have provided Infinity with over $60 million in upfront and committed funds, as well as potential milestone and royalty payments, Amgen, Novartis, and Johnson & Johnson are using Infinity’s
collection of DOS compounds in their own drug discovery efforts. While Infinity has non-exclusively licensed its compound collection to these pharmaceutical partners, Infinity recently announced it first partnership involving product candidates
discovered by Infinity from its DOS collection. 
 About Infinity Pharmaceuticals, Inc. 
 Infinity is an innovative cancer drug discovery and development company that leverages its strength in small molecule technologies to bring important new medicines to patients. 
  

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 Editor’s Note: This release is available in the Press Release section of the Media Room of Infinity’s website
at http://www.ipi.com 
 # # # 
  

			
	Contacts:	  	
	Adelene Q. Perkins	  	Paul Kidwell (media)
	Executive Vice President, Chief Business Officer	  	Suda Communications
	Infinity Pharmaceuticals, Inc.	  	617-296-3854
	617-453-1104	  	paul_kidwell@comcast.net
	Adelene.Perkins@ipi.com	  	

  

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