Document:

April 17, 2013

 

Qi Long Chen

Hong Kong Baoying Investment Holdings Limited

Suite 3711-12, Office Tower Langham Place,8 Argyle Street

Mongkok, Kowloon, Hong Kong

Tel:(852) 2117-0478 Fax: (852)2117-9609

 

Mr. Chen,

 

This is to advise you that the Strategic Joint Venture Agreement
(the “Agreement”) between E-World USA Holding, Inc. and Hong Kong Baoying Investment Holdings Limited, dated and signed
on August 6, 2012, is formally terminated.

 

Paragraph 3 of the Agreement provides as follows: Party B is
responsible for investment. First investment will occur 10 days after signing of this contract of US$5 million to be wired to Party
A’s Hong Kong or USA bank account.

 

As you know, no such payment was received within 10 days of
the signing of the Agreement and in fact no such payment has been received to date.

 

On September 7, 2012, we wrote you as follows: If your company
is unable to fulfil the contract, please cancel it and inform us — as early as possible.

 

The next day you replied: [W]e are temporarily unable to make
fund available for that plant. We can, however, continue to negotiate with you when the conditions are met.

 

We have heard nothing further from you in this regard and given
the passage of time and your continued breach of the terms of the Agreement without any further attempt at negotiations on your
part, you have abandoned the Agreement of which you are in breach and the Agreement is formally terminated as of the date of this
letter.

 

Regards,

 

Dinghua Wang

CEO and President

E-WORLD USA HOLDING, INC.生物高科技-細胞小分子營養食品
Bio-tech Micro Molecules Nutrition Supplement

OPCSpa

 

Made
from

100%
herbal extracts

 

 

A. OPCSpa Characteristics

  

1. Made from Oligomeric
Proanthocyanidins (OPC), 100% herbal extracts;

2. 20 times more
efficient than Vitamin C and 60 times more efficient than Vitamin E;

3. Small molecule
structure fights the lipid oxidation of cell membranes;

4. Helps fight oxidation
and free radicals;

5. Strengthens the
human immune system and cell metabolism against cell mutation;

 

B.OPCSpa Ingredients

 

Oligomeric
Proanthocyanidins (OPCs),Lycopene, Grape Seed Extract, Pycogenol, Green Tea Polyphenols(GTP), Red Wine Extract, HPM (Veg- giecap)
, 500mg / capsule.

 

C.OPCSpa
Functions and Effects

 

As
a natural nutrition substance, the product has the following functions:

●
Improves the resistance and functions of mi- cro-vessels;

●
Improves the resistance of the immune sys- tem;

●
Improves the recycling operation of the retina and improves sight;

●
Mollifies adverse reactions to inflammations;

●
Slows down the aging process and loss of elasticity process of the skin;

●
Participates in the prevention of cancer, allergy, aging, inflammation and ulceration.

 

D.
Helpful for the following symptoms

 

Helps
with allergic illnesses, cancer, aging, wrin- kled skin, persistent prostatitis, prostate hyper- trophy, arthritis, cataract,
heart diseases, se- nile dementia, hypertension, arteriosclerosis, gastric ulcer, athletes trauma, poor immunity, cataract,macular
degeneration, nyctalopia, retina diseases, varicosity; vessel diseases, scurvy and urinary system inflammation in chronic diabetes
patients, kidney stone and arteriosclerosis.

 

Target
group: students, teachers, computer work- ers, banking staff, drivers, pilots, policemen and computer game fans.

 

E.
Dosage

 

General
dosage: 1-2 capsules each time, two times per day Intensive dosage: 2-3 capsules each time, three times per day It has no side
effects even after long-term admin- istration. Can be taken during meals.

 

Understanding
the Anti-oxidation Effect of OPCSpa

 

OPCSpa
consists of Pycnogenol and 95% original anthocyanin, which is the most effective antioxi- dant for human cell metabolism and in
removing free radicals. It can be absorbed quickly in the human body. Researches proved that 80% of the diseases are caused by
excessive amount of free radicals, such as allergy and allergic asthma. Be- ing a difficult problem in modern medical science,
allergy is troubling many patients. Out of 50 years study, scientists from Europe and America found that the cause to allergy
is free radicals, which crack up mast cells and alkali cells, and release genes that cause allergy. Below is an analysis to the
ingredients and effects of OPCSpa:

 

    	 

    	 

    

 

Bio-tech
Micro Molecules Nutrition Supplement 生物高科技-細胞小分子營養食品

 

A.Effects of
Oligomeric Proanthocyanidins (OPCs) :

 

Oligomeric
Proanthocyanidins sight-improving and anti-oxidation capsule is a powerful antioxidant, and is helpful for heart diseases, hardened
blood vessels, cancer, glaucoma, cataract, venous tumor, diabetes, and nyctalopia. It is a perennial shrub that grew originally
in North Europe, North America and Canada. The blackish purple color- ed fruit of Oligomeric Proanthocyanidins, which is often
called the “blueberry of Europe,” is easily confused with the blueberry from American.

 

Research
showed that Oligomeric Proanthocyani- dins has a more valuable effective ingredient than the blueberry, i.e. the anthocyanin.
It is because of this reason that the former is extensively used to treat nyctalopia and sight improvement, rather than be made
into jam or food materials as the blueberry. The market price of genuine Oligomeric Proanthocyanidins is 25 times the price of
its likes. Many anti-oxidation products on the market claim to contain Oligomeric Proanthocyanidins, but it is only replacements
of Oligomeric Proanthocya- nidins. The composition and effects of these re- placements are quite different from Oligomeric Proanthocyanidins.

 

Oligomeric
Proanthocyanidins is said to be a se- cret weapon among the pilots! The topic “Oligo- meric Proanthocyanidins improves sight”
caught the attention of the scientists was because during the WWII, before the pilots from the Royal British Airforce executed
bombing tasks during nights, they would be given drinks containing Oligomeric Proanthocyanidins jam. Research showed that Oligomeric
Proanthocyanidins accelerate the re- generation ability of rhodopsin, thus improving the sharpness of sight. This helped the pilots
much, who are expected to judge flying conditions with their eye and to have very good eye sight.

 

Research
on Oligomeric Proanthocyanidins has expanded to the protection of blood vessels and other fields. People now extensively use the
an- thocyanin that is rich in the ripened fruits of Oli- gomeric Proanthocyanidins to treat many condi- tions, including bloodpoisoning,
urinary system infections, kidney stone, arteriosclerosis, cataract, macular degeneration, nyctalopia, pathological change in
the retina, varicosity, and blood vessel conditions in chronic diabetes patients.

 

Oligomeric
Proanthocyanidins and healthy eyes: First, scientists noticed that most of the eye-related problems are caused by conditions in
the retina, bone glue or intraocular pressure, all of which can be traced to the blood circulation within the eye. With the increase
in age, the metabolism process gets down, and the overuse of the eye causes free radical damages, poor blood circulation and ab-
normalities in the smoothness of capillary circula- tion. Therefore, when the eyeball, being one of the nerve ends, does not receive
enough nutrition, the bone glue substances within the eyeball will drop, which affects the elasticity of the eye ball so that
it is prone to be distorted or become inelas- tic. Because of the poor blood circulation, some fluid tends to gather in the eye
and causes abnor- mal pressure so that the eye pressure increases, and causes irritation, soreness, or even damages in the eye
tissue and the occurrence of glaucoma and cataract. Therefore, the anthocyanin content in Oligomeric Proanthocyanidins is widely
used to maintain the intactness of blood vessels, the elas- ticity in capillaries, as well as normal blood circula- tion and normal
eye pressure. The extract of Oli- gomeric Proanthocyanidins does not produce any side effect, and will not interfere with the
general drugs. No side effect is found in pregnant patients or patients in lactation.

 

B.
Effects of Lycopene :

 

Lycopene
fights oxidation and cell tumorigenesis. In March, 1997, during an international academic forum held by American Health Fund in
New York, the effects of Lycopene and tomato products in fighting cancer were extensively discussed. Ex- perts and scholars from
all over the world dis- cussed intensively the of tomato and carotenoid, which is also called Lycopene, to the health of the human
body. The research teams led by many ex- perts and scholars have proven out of epidemio- logicstudies and experiments that Lycopene
helps the human body fight many cancers, including prostate cancer, breast cancer and cancer in the alimentary canal (such as
large intestine cancer, rectum cancer and stomach cancer), as well as reduces the risk of cardio blood vessel conditions.

 

    	 

    	 

    

 

生物高科技-細胞小分子營養食品
Bio-tech Micro Molecules Nutrition Supplement

 

Lycopene
is one of the more than six hundred types of carotene in nature. It is not in a loop structure, but its ability to remove the
singlet oxy- gen free radicals is two times stronger than theβ- carotene, and 100 times stronger than Vitamin E. Since Lycopene
cannot be produced within the human body, we can only get it from our diet. Many fruits contain Lycopene, especially red- colored
fruits, such as the pin grapefruit, almond, guava, papaya, and water melon. However, to- mato remains the best source. Studies
show that a hundred kilograms of fresh tomatoes contains about 0.88-4.2mg Lycopene. The more ripened and red a tomato is, the
more Lycopene it con- tains. This figure for pink grapefruit is 3.36mg, for guava 5.4mg, and water melon 4.9mg.

 

The
content of Lycopene depends on the type, growth method, harvesting ripeness and storage conditions of tomatoes. Overseas studies
show that the content of Lycopene in the type called Flavourtop is about 4950ug /100g, and in Gold Sunrise only about 21ug /100g.
Tomatoes grown on soils treated with 300kg ammonium nitrate per hectare contain more Lycopene than those grown on soils treated
with 100kg ammonium nitrate per hectare. Red and ripened tomatoes contain 2.5 times more Lycopene than pinkish tomatoes. If stored
under 18oC, the pinkish Sunny type toma- toes contain more Lycopene than those stored under
0oC. Therefore, farmers could choose the right type and fertilization method to increase
the content of Lycopene in tomatoes. As a general customer, you may choose red and ripened toma- toes stored under a temperature
of above 0oC.

 

The
research team led by Dr. Giovanucci from Harvard Medical School found that a diet rich of tomato products contains powerful antioxidant
and can thus remove redundant free radicals with- in the body and reduce the risk of prostate cancer. During the six years between
1986 and 1992, re- searchers studied on more than 47 thousand men between the age of 40 and 75, observing their health conditions
and dietary habits. They found that the risk to get prostate cancer for those who took tomato-related products every week was
21% to 34% less than the rest.

 

Other
studies show that the anticancer ability of Lycopene goes beyond the prostate cancer. Vitro experiments carried out by the Israeli
BenGurion University and Seroka Medical Center showed that Lycopene also prevents the growth of breast cancer, lung cancer and
endothelial cancer cells. Many medical studies from overseas countries also report that Lycopene not only removes free radicals,
but reduces the risk of cancer, protects low-concentration lipoproteins from free radicals, lowers the concentration of cholesterol
in blood, thus preventing cardio blood vessel conditions.

 

Researchers
from India show that Lycopene helps in improving the sterility in males. The Lycopene in water melon, grapefruit, tomato and other
fruits and some of the shellfishes can increase the quantity of sperms. The National Medical Asso- ciation of India made a study
on 30 sterile men aged between 23 and 45. Researchers found that the content of Lycopene in these men were low, so that they were
administered 2mg Lycopene twice daily for three months. After three months, the quantity and activity of sperms produced by them
increased evidently. There was also a case that six sterile men successfully impregnated their spouses after treatment, which
proved the direc- tion effect Lycopene has on sterility. Research- ers report that the oral administration of Lycopene indeed
helps to treat sterility caused by uncertain reasons.

 

C.
Effects of Green Tea Polyphenols (GTP) :

 

Green
Tea Polyphenols (GTP) is a general name for Catechins, flavonoids, phenolic acids, Anthocyan and other chemical compounds. It
accounts for 15% to 25% of the total dry weight of tea. The most important content in GTP is catechins. The multiple active –OH
base in the molecules of GTP can stop the chain reaction of free radicals within the human body, thus removing the O2-. It has
similar effects of SOD. GTP can remove as much as more than 98% OH- and over-oxidized free radicals, which is more effective than
Vitamin E and Vitamin C. GTP protects cell membranes and cell walls, and removes very effectively the over-oxidized free radicals
in lipids. GTP restrains and kills bacteria. It can effectively lower the absorp- tion of cholesterol by the large intestine,
and pre- vent arteriosclerosis. It is a powerful restraint for HIV reversion enzyme. It improves the immunity, prevents tumor,
fights radiation, and slows down the aging process. Toxicological studies show that GTP is safe and toxic-free. Below are some
of the ways GTP (primarily catechins) can be used:

 

    	 

    	 

    

 

Bio-tech
Micro Molecules Nutrition Supplement 生物高科技-細胞小分子營養食品

 

1)
Anti-oxidation for lipid :

GTP
is a natural anti-oxidant for lipid. Its anti- oxidation activeness is better than the artificially synthesized BHA and BHT as
well as Vitamin E. It is widely used in the food industry to prevent and delay the oxidation and decay of lipids.

 

2)
Pigment protection :

GTP
prevents the degeneration and bleaching of natural pigments and β- carotene. It is said that its effect is 20 times higher
than Vitamin C.

 

3)
Deodorant :

As
GTP is very effective in removing the odor of methyl mercaptan, it is used in Japan in the mak- ing of deodorant gums and cigarette
filters to pre- vent the bad breath of smokers. Researchers have done tests on the excrements of hogs, chicken and human. After
two-weeks dietary intake of GTP, the odor of the excrements moderates, because GTP can kill and restrain many stinky bacteria
within the intestine.

 

4)
Prevents oxidation and delays aging :

GTP
can remove the redundant free radicals with the body, protect the structure of cell membranes, and delay the aging process. A
number of experi- ments show that GTP has stronger anti-oxidation activeness than Vitamin E. This effect becomes even more stronger
when administered together with Vitamin C and Vitamin E.

 

5)
Anti-cavity :

The
anti-cavity effect of tea used to be considered the effect of fluorine in the tea water. Fluorine can replace the hydroxyl in
the hydroxylapatite of teeth and become fluorapatite, to give protection to the teeth enamel against the corrosion of acid substances.
It is clinically proven that GTP is pow- erful in restraining bacteria that cause cavity, and in reducing tooth plaque and pericoronitis
risks, while producing no adverse effects on beneficial microbes in the oral cavity.

 

6)
Antiseptic and anti-virus :

Green
tea and scented tea are more antiseptic than red tea. This has something to do with the amount of GTP in them. Some people believe
that the antiseptic effect of GTP comes from the ability of polyphenols to deposit bacterial proteins, which will be denaturalized
and deactivated. Modern sci- ence believes that the effect of tea primarily comes from catechin. Catechin restrains many microbes
that are detrimental to human health, such as bot- ulinum toxin, while having no bad effects on the reproduction of microbes that
are beneficial to the intestines, such as lactobacillus. There are clini- cal reports of cases in which tea water is used to treat
Shigellosis and to restrain the reproduction of pathogenic bacteria.

 

7) Lowers blood fat and relieves
arteriosclerosis : GTP plays an important role in fat metabolism of an organism. It effectively restrains the increase of cholesterol
content in blood plasma and liver, and helps discharge lipid compounds in excrements. Therefore, it not only prevents arteriosclerosis,
but reduces weight and fat. A study team from a medi- cal university gave away GTP medicines to 200 people in 4 groups. After
a ten-month administra- tion, the team conducted a double blind control ex- periment, and found that GTP lowered the content of
cholesterol and triglyceride in blood serum by about 19%. They also noticed that the difference of ratios between high-concentration
lipid protein and low-concentration lipid protein before and af- ter the experiment was 36.1%, which indicated that GTP has a
potential effect to prevent high blood fat, coronary heart disease and arteriosclerosis.

 

8)
Multiple medicinal effects :

GTP,
and especially its catechin derivatives re- strain tumor cells and mutation. Moreover, cate- chin derivatives can also alleviate
the detriment of heavy metals to human health, and protect the hu- man body from radiation. A prestigious American company developed
foundation liquids containing catechins, and indicates in the description of the cosmetic that it can prevent skin cancer caused
by ultraviolet radiation and the pre-aging of the skin.

 

    	 

    	 

    

 

生物高科技-細胞小分子營養食品
Bio-tech Micro Molecules Nutrition Supplement

 

D.
Health protection effects of grape seed extract:

 

Grape
Seed Extract Proanthocyanidin (GSPE) is the most popular antioxidant on the market to remove free radicals. The absorption rate
is over 95%. In Europe, grape seed is called the “cos- metic for the skin that is taken orally.” It is one of the
most effective antioxidants that nature gives us. It does not only prevent the early wrinkling of the skin, but nurtures the skin
and removes free radicals. 95% contents in clean and pollution-free grape seed extracts are a group of natural sub- stances called
Oligomeric Proanthocyanidins.

 

GSPE
is also a natural polyphenol compound that is one of the flavone. [1~4]These compounds are the polymerization of flavanols of
different num- bers, heated in acid solutions to produce leucoan- thocyanins or proanthocyanidin, which is also called pycnogenols.
[5, 6]The most extensively studied are 5,7,3’,4’-tetrahydroxyflavan-3-o1 in grape seed, i.e. compounds that are polymeriza-
tions of (+)-catechin and (-)-epicatechin, which is also called leucocyanidins or procyanidins. [7] is a powerful antioxidant
and is usually found in fruit skin or plant stems. It primarily protects the contents in plants that are easily oxidized. As ear-
ly as in 1950s, scientists in France were able to extract large amounts of proanthocyanidin from pine barks. As high as 85% of
these extracts was proanthocyanidin. In 1970s, it was found that grape seed is a better resource for proanthocyani- din, in which
the content of proanthocyanidin is as high as 95%. Studies in the latest decades found that proanthocyanidin is beneficial to
the human body in many ways:

 

A)
Prevents the early wrinkling of the skin :

 

In
Europe and America, grape seed extract is con- sidered the “vitamin for skin” and the “cosmetic orally taken.”
Skin is a connective tissue, the col- lagen and elastin in the skin play an important role to build its structure. The moderate
crosslinking of collagen maintains the intactness of the skin. However, free radicals can cause collagens to over-crosslink, so
that wrinkles and cysts appear on the skin. The grape seed extract can help col- lagens to crosslink moderately and remove free
radicals, so as to keep the skin smooth and sup- ple. In addition, elastins can be degenerated by free radicals and elastasees,
whereas grape seed extract can eliminate free radicals, stop the repro- duction of elastasees or reduce their activeness so as
to improve the conditions of the skin.

 

Researchers
[2] have conducted epidemiologic re- sistant studies on grape seed extract, which indi- cated that the ratio of GSPE against IC50
(μmol/L) xanthine oxidase, elastasee, collagenase, hy- aluronidase, and β-Glycuronic acid sugar gluco- side enzyme are
respectively 2.4, 4.24, 38, 80 and 1.1. GSPE is very effective in restraining the above-mentioned enzymes.

 

The
grape seed contained in OPCSpa is a natu- ral sun block that protects the skin from ultraviolet harms. Dr. A. H. Arstilla from
Finland found in his experiments that the sun can kill 50% human skin cells; but when protected by grape seed, 85% skin cells
will survive. Free radical is one of the most important causes for the aging process and many other conditions. It is estimated
that 80% to 90% age-related conditions have something to do with free radicals, including cancer, senile dementia, Parkinson’s
Disease, skin pigment, cataract and heart diseases. The proanthocyanidin in grape seed repairs the damaged collagen and elastin
fibers. Therefore, grape seed protects both from within and from without: preventing the early ap- pearance of wrinkles, and keeping
the skin smooth and elastic forever.

 

B)
Removes detrimental free radicals in the body :

 

In
1980s the effects of free radicals on human health was gradually learned. According to modern medicine and nutriology, free radicals
cause many diseases directly or indirectly. The Gradu- ate Student College of France Science Academy conducted an experiment on
the effect of GSPE in removing free radicals, and found that GSPE is one of the most effective remover of free radi- cals found
by far. Its activeness within the body is incomparable by other antioxidants. Bagchi.D[3] conducted an experiment on mice, comparing
the effect of GSPE of protecting TPA-induced liver and brain tissues from the over-oxidation with that of VC, VE and β- carotene.
It was found that at a dosage of 100mg/kg BW, GSPE, VC, VE and β- carotene all reduced the amount of reactive oxy- gen produced
out of TPA induction, the ratio being respectively 70%, 18%, 47% and 16% with the peritoneal macrophage luminescent method, and
65%, 15%, 37% and 19% respectively with the cytochrome restoration method. Also found was a dosage reaction relationship between
GEPS and the production of reactive oxygen in perito- neal macrophage. The result of the experiment showed that GSPE gives a better
protection than other antioxidants against damages caused by oxidization. The epidemiologic studies conducted by Bagchi.D[10]
also found similar results.

 

    	 

    	 

    

 

Bio-tech
Micro Molecules Nutrition Supplement 生物高科技-細胞小分子營養食品

 

Free
radical is one of the most important causes for aging and many other related diseases. It is estimated that around 80% to 90%
age-related conditions have something to do with free radi- cals, including including cancer, senile dementia, Parkinson’s
Disease, skin pigment, cataract and heart diseases. Therefore, removing free radi- cals helps much with a healthy body and youthful-
ness. Proanthocyanidin in OPCSpa is more than 50 times stronger than Vitamin E and more than 20 times stronger than Vitamin C
in fighting free radicals.

 

Control
experiment examining the anti-oxida- tion abilities: Researchers examined the abil- ity of GSPE, VC, VE, β - carotene, superoxide
dismutase, catalase and mannitol in removing OH- free radicals and –OH free radicals with the chemical luminescent method
and cytochrome C restoration method. The results showed a con- centration reaction relationship between GSPE and its restriction
on free radicals. With a concen- tration of 10mg/L, the restriction ability of GSPE over OH- free radicals and –OH free
radicals were 78% and 81% respectively. Under the same conditions, these figures for Vc were 12% and 19% respectively, for Ve
50% and 75%, and for superoxide dismutase and catalase when acted jointly about 83% against OH- free radicals, and for mannitol
87% for –OH free radicals. In conclu- sion, GSPE is a much more powerful free radical eliminator than Vc and Ve.

 

C)
Reduces the risk of inflammations in tissues:

 

Proanthocyanidin
in OPCSpa is more than 50 times stronger than Vitamin E and more than 20 times stronger than Vitamin C in fighting free radi-
cals. Proanthocyanidin in OPCSpa reduces the risk of inflammations in tissues by restraining pros- tate gland, cytokinin, histamine,
lipoxygenase and cyclooxygenase.

 

This
effect of Proanthocyanidin in GSPE caught the attention of scientists as early as in 1950s. its anti-oxidation ability restrains
the synthesis and release of inflammation genes such as histamine, -hydroxytrypamine, prostaglandin, and leukot- riene, and restrains
basophilic cell and mast cells in releasing allergic particles, thus improving skin allergy and allergic asthma symptoms effectively.
In addition, it can also restrain the activity of HDC, and restrain the effects of hyaluronidase, [21] thus helping with the treatment
of arthritis, gastric ulcer and duodenum ulcer.

 

D)
Relieves allergy and allergic reactions :

 

Proanthocyanidin
in GSPE can reduce the release of histamine, and help the redundant histamine within the body to reenter cells. It can also re-
strain the degranulation of mast cells, thus allevi- ating conditions such as allergy, asthma and hay fever. OPCSpa is the ideal
nutrition supplement recommended by clinicians.

 

E)
Strengthens blood vessels and improves circu- lation :

 

Proanthocyanidin
in GSPE is used to improve the immunity of blood vessels and reduce the perme- ability of capillaries. Several experiments on
cap- illary permeability have proved its anti-oxidation effect and anti-enzyme effect. [11, 12] With the increase in age, elastin
fibers in arteries become hardened because of oxidization, and arterioscle- rosis is a key cause for cerebral and cardio blood
vessel diseases among the elderly. Another key cause for arteriosclerosis and heart diseases is the increase of low-concentration
lipid proteins and cholesterol within the body.

 

    	 

    	 

    

 

生物高科技-細胞小分子營養食品
Bio-tech Micro Molecules Nutrition Supplement

 

Animal
tests and clinical tests showed that the proanthocyanidin in GSPE can effectively lower the level of cholesterol and low-concentration
lipid protein, prevents the formation of thrombus, and prevents the occurrence of cerebral and cardio blood vessel diseases. [13]Preuss
HG[14] stud- ies also indicated that proanthocyanidin in GSPE, when acting together with cadmium and zinc, can lower the increase
of systolic pressure caused by increase of age among normal rats. In the tests, rats in the control group were given basic feed-
stuff, while 5 mg/kg Gr, 18 mg/kg Zn, 260 mg/ kg proanthocyanidin were given into the feed- stuff for rats in the test group.
The initial blood pressure of the two groups was both 122mmHg. Seven months later, the ystolic pressure of rats in the control
group raised to 140mmHg, whereas in contrast that of the rats in the test group lowered to between 110~114 mmHg during the first
few months, and then raised to 120mmHg, which was much lower than in the control group.

 

Researchers
believe that aging and age-related chronic disease have something to do with the glycation of protein/nucleic acid and tissue
trau- mas caused by the increase of free radicals. The resistance of insulin that appears with the increase in age might be the
foundation for glycation and the formation of free radicals. In researches re- garding the effect of GSPE and cadmium and zinc
on insulin sensitivity, it is noticed that the effect comes into play be reducing the formation of free radicals. In addition,
with the increase in age, the elastin fibers harden from the oxidization process, which is a main cause of hypertension among
the elderly. Proanthocyanidin in GSPE can lower the blood pressure by improving the elasticity of blood vessels. Animal tests
and clinical studies show that it lowers the blood pressure by lowering the level of cholesterol, reducing the cholesterol sedi-
ment on vessel walls and restraining the activity of vessel tension enzymes.

 

The
Proanthocyanidin in OPCSpa can improve blood circulation, restore the capillary functions lost, and strengthen up fragile blood
vessels, mak- ing them more elastic. Proanthocyanidin is called the Atherosclerosis Antidote. For those suffering from insufficient
artery and vein functions, Proan- thocyanidin could help to ease pain, edema and nocturnal spasm, so that many clinicians recom-
mend OPCSpa to their varicosity patients.

 

F)
Improves eyesight :

 

Researchers
conducted experiments on men to examine the effect of Proanthocyanidin on eye fatigue, [22] administering GSPE Proanthocya- nidin
300mg daily to 75 cases those who work permanently before a computer screen. After two months, the relative sensitivity and subjec-
tive symptoms evidently improved. In clinical ex- periments on short-sighted cases, 150mg GSPE Proanthocyanidin is administered
to 200 cases who suffer from non-inflammation retina changes. After two months, it is reported that the sight of these cases improve
greatly [23, 24].

 

Now,
GSPE Proanthocyanidin is used extensively. Its health protection function comes from its abil- ity to remove free radicals. Besides,
it also has great biological potentials. When combined with collagens, it can stabilize the activity of cell mem- branes and resistant
enzymes, which will make it a popular health supplement.

 

Proanthocyanidin
in OPCSpa improves the sight. A clinical research conducted in Europe on 100 cases with no eye conditions discovered that Proanthocyanidin
can improve sight under dim light, which means it will be helpful for night driv- ers and computer workers. Doctors in Europe
and America also recommend it to their patients who suffer from retina conditions caused by diabetes.

 

G)
Fights cancer :

 

The
cancer-fighting ability of Proanthocyanidin in GSPE has been extensively covered. The epi- demiologic study by S. S Joshi et al
[15] noticed the cytotoxicity of proanthocyanidin on some tu- mor cells. Used in the study were MCF-7 human breast cancer cells,
A-427 human lung cancer cells, CRL1739 human stomach cancer cells and K562 chronic leukemia cells, and the concentra- tion of
proanthocyanidin used was 25, 50 mg/L. The observation time point was 0 – 72 h. When compared with the normal stomach mucous
mem- brane and the normal J774A1 urethra epithelium cells, it was found that 25mg/L proanthocyanidin has cytotoxicity against
MCF-7 human breast cancer cells, A-427 human lung cancer cells, and CRL1739 human stomach cancer cells. Its restric- tion of cancer
cell growth at 24, 48 and 72 h was respectively 7%, 30%, and 43%; at 50mg/L and some time points its restriction against MCF-7
hu- man breast cancer cells was 1%, 30% and 47% respectively; similar effects on A-427 human lung cancer cells and CRL1739 human
stomach can- cer cells were observed, but not on K562 chronic leukemia cells. In addition, Proanthocyanidin
in GSPE facilitates the growth and survival of normal human stomach mucous membrane and the nor- mal J774A1 urethra epithelium
cells.

 

    	 

    	 

    

 

Bio-tech
Micro Molecules Nutrition Supplement 生物高科技-細胞小分子營養食品

 

In
studies about the relationship between tobacco and cancer, M.Bagchi et al [16] also explored the protective effect proanthocyanidin
has on oxidiza- tion restriction and cell apoptosis of keratinocytes of the human oral cavity induced by smokable to- bacco extracts
(STE). Statistics show that in the US 1/3 of all tumors are tobacco related, oral cav- ity cancer accounting for 3% of all tumors.
In their experiment, they studied the effect of STE on lipid peroxidation (LP), cytochromes restoration (CCR), DNA fraction and
cell apoptosis, and evaluated the protective effect of various antioxidants. [Separate and culture cells from the human oral cavity
tissue, treat them with STE (0~300 μg/mL) for 24 hours, examine the generation of superoxide anions with CCR, examine tissue
oxidization and trauma with LP and DF, and examine the programmed cell ap- optosis with Flow Cytometer.]

 

The
protective effect of 75 μmol/L VC, 75 μmol/L VE, VC+VE and 100 μmol/L GSPE proanthocya- nidin on the above-mentioned
traumas were then compared. After the cells are treated with 300 μg/mL STE, it was observed that LP and DF in- creased by 3.5
to 6 times. When treated with anti- oxidants, the protection was between 34% to 69%. After treated with 100,200, and 300 μg/mL
STE, the programmed cell apoptosis increased respec- tively by 9%, 29% and 35%. After the treatment with antioxidants, the protection
increased by 40% to 72%. Similar results were noticed in LP, CCR and DF experiments. Results showed that GSPE proanthocyanidin
is the most effective antioxidants among all.

 

H)
Prevents radiation :

 

The
free radical theory is a basis for trauma caused by radiation. After radiated, an organism produces from within, which causes
lipid peroxidation and other damages. GSPE proanthocyanidin is ef- fective in eliminating free radicals and restraining damages
resulted from oxidization.

 

According
to a test report, [17] mice loaded S180 sarcoma were given 60 Co γ local radiation, oral intake of GSPE proanthocyanidin,
and local ra- diation plus oral intake of GSPE proanthocyani- din. 12 days after the loading of tumor cells, the tumor weight,
white blood cell amount, spleen lymphocyte conversion and other indices were examined. The result showed that the average tumor
weight of the control group was the high- est; the restriction on tumor in the group treated with radiation plus high-dosage proanthocyanidin
administration was found higher than the other two groups; the amount of white blood cells in the group singularly treated with
radiation was lower than the other two groups. The statistical t and χ2 examinations found great disparity (P<0.05).

 

The
result also showed that compared with the group that did not receive radiation, the MDA lev- els of the other two groups were
higher, which ap- parently had something to do with the intensified reaction of lipid peroxidization and the accumula- tion of
oxidization products within the body. The administration of GSPE proanthocyanidin lowered the MDA level, the bigger the dosage,
the greater the decrease, which indicated that proanthocya- nidin restricted the lipid peroxidization caused by radiation. This
might be the main reason that proanthocyanidin prevents damages caused by radiation.

 

Russians
have long realized the protection proan- thocyanidin has over damages caused by radia- tion. Russian astronauts have been given
a veg- etarian drink rich in proanthocyanidin, which helps them avoid damages from radiation when flying in a spaceship. The explosion
of Chernobyl Nuclear Power Station in the Soviet Union resulted in se- rious nuclear pollutions, and many people living nearby
were traumatized. Then a red wine called Crimean was suggested to them – one that rich in proanthocyanidin to alleviate
the adverse effects nuclear leakage caused to the human body.

 

All
in all, the protection of proanthocyanidin on ra- diation is drawing more attention. While bringing people great benefit in their
lives and work, such as TV, computer, microwave oven and mobile phone, the development of modern technology is also jeopardizing
human health with a bigger exposure to electromagnetic radiation. Health supplements containing proanthocyanidin to fight against
radia- tion damages will have a great future.

 

    	 

    	 

    

 

生物高科技-細胞小分子營養食品
Bio-tech Micro Molecules Nutrition Supplement

 

I)
Prevents mutation :

 

1)
Test on mitochondrion mutation :

Used
Saccharomyces cerevisiae S228C(α- prototroph)cells, and regarded the mutant of Respiratory Deficient as the manifestation
of mi- tochondrion mutation. The occurrence of mutants was recorded. The result shoed that at 0, 0.25 and 0.5mg/L GSPE proanthocyanidin,
the occurrence of mutation was respectively 1.7×10-2, 0.9×10-2, and 0.6×10-2, with the ratio between the control
group and the test group being respectively 1, 0.5 and 0.35. It is obvious that GSPE proanthocyani- din can effectively lower
the occurrence of mito- chondrion mutation [18].

 

2)
Test on nucleus mutation:

Used
Saccharomyces cerevisiae S228C(α - pro- totroph )cells. The number of L - canvanine sen- sitive mutated as L-canvanine tolerant
was re- corded. The result showed that at 0, 0.25 and 0.5mg / L GSPE proanthocyanidin, the occurrence of nucleus mutation was
respectively 1.95×10-8, 0.25×10-8, and0.15×10-8, with the ratio between the control group and the test group
being respec- tively 1, 0.12 and 0.08. The occurrence of nucleus mutation in the test group reduced by 88% to 92% [19, 20].

 

E.
Health effect of pine bark (Pycnogenol) :

Pycogenol
is an antioxidant extracted from the bark of the rare Conifer Pinus Pinaster growing along the south coast of France. Pycogenol
is a water - solvent biological flavone extract contain- ing many organic acides, including catechins, pro- cyanidis, taxifolins
and phenolic acids. It’s a pow- erful antioxidant that fights against free radicals that damage cells.

 

Pycogenol
strengthens blood vessels, facilitates blood circulation, restrains inflammation, helps bruises to heal, and prevents cells from
mutation. It also has the following effects:

 

1)
Makes the skin healthier :

Pycogenol
protects the collagen of the skin, keep- ing it elastic and supple. It prevents the early signs of wrinkles, protects the skin
against suntan, and prevents acnes and eczema.

 

2)
Mollifies chronic fatigue syndrome :

Pycogenol
improves blood circulation within the brain, preventing headache, irritation, difficulty in concentration, insomnia and other
chronic fatigue symptoms.

 

3)
Eases premenstrual syndrome :

Pycogenol
regulates hormone secretion, balanc- ing the level of free radicals within the body and al- leviating premenstrual conditions,
such as anxiety, depression, ache, fatigue and insomnia.

 

Pycogenol
also relieves pains in arthroses. It re- stores the collagen in the damaged connective tis- sues, improves the activity of the
joints, thus eas- ing pains in the arthroses, neck and back.

 

4)
Prevents senile dementia :

After
death, cerebral nerve cells will not revive, and free radical is the cause for cerebral cell death. Pycogenol can fight against
damages caused by free radicals and delay the aging process.

 

It
is recorded that pine bark was used medically as early as in the thirteenth century. In the winter of 1534, the French adventurer
Jacques Cartier ex- plored Canada in a boat. On his way, most of his crew died from blood poisoning, and it was lucky for him
to meet an Indian who taught them pre- paring tea with pine bark. This saved many lives. Four hundred years later, pine bark was
studied in colleges and was found rich in biological flavo- noids.

 

F.
Heath effects of red wine extract :

 

Past
studies indicated that red wine prevented the attack of heart diseases. Recently, a research re- sulted published by an American
scientist proved that grape skin and grape seed contain a natural chemical substance that prevents cancer.

 

Scientists
extracted a dimmer called β -prccycli- dine from grape skin and seed, and applied it on mice loaded breast cancer. The result
showed that the chemical caused the tumor to shrink.

 

    	 

    	 

    

 

Bio-tech
Micro Molecules Nutrition Supplement 生物高科技-細胞小分子營養食品

 

According
to the researchers, presently there are some medicines on the market that can control the development of conditions in estrogen-reliant breast cancer cases. The natural chemical
they refined has the same function on restraining the development of breast cancer. Researchers also indicated that they were
quite astounded that they could extract this chemical from natural resources. In addition, the test proved that the extract greatly
reduced the size of the breast cancer within the body of all mice tested. It is even more astonish- ing to know that the tumors
in some mice totally disappeared.

 

Researchers
believe that this natural extract is more effective when used for prevention than for treatment, because the cancer-fighting medicines
currently existing are quite effective. Therefore, it is suggested that mature females take in this natural compound in their
diet, such as red wine [containing 25% to 45% red wine extract], so as to prevent breast cancer when in the future their estrogen
level drops.

 

According
to the researchers, amongst females in menopause who suffer breast cancer, 70% cases are caused by a high level of estrogen. There
is a treatment to reduce the generation of estrogen by reducing the activity of aromatase, so that breast cancer is forced to
stop growing because of the lack of continued supply of estrogen. The natural substance they extracted from grape functions in
much the same way.

 

Researchers
clarified that they recommend red wine to females for the prevention of breast cancer. This does not mean that females are encouraged
to drink excessively. The dosage on mice is half a bottle wine daily. For healthy females, a glass of wine or some grapes (with
the skin and seeds) a day is enough to lower the amount of estrogen in circulation. When asked why white wine does not have the
same effect, researchers said that the materials used in red wine making are intact grapes, i.e. grapes with the skin and seeds,
and after the fermenting process the liquid is no longer simply grape juice. In contrast, white wine is often made from grape
juice, and without the skin and seeds it does not have the cancer-fighting effect.

 

G.
How to take OPCSpa :

 

Take
one pill morning and evening. It produces no side effects even after long-term use.

 

Take
continuously ten days for healthy people, and 25 days for those that have any conditions for pronounced health-improving effect.

 

The
dosage can be adjusted according to the physics and health conditions of different people. The dosage can be increased for those
who have greater exposure to the sun.

 

It
is normal if you experience headache. Please be assured that there is no problem in continuing the administration.

 

H.
OPCSpa FAQ

 

1)
What is proanthocyanidin?

All
vegetables in nature that have various colors contain proanthocyanidins, therefore it is beneficial to our skin and body to eat
more fruits and vegetables. However, the proanthocyanidin we take daily is very limited. Scientists discovered that the content
of proanthocyanidin in grape seed is as high as 95%. The natural OPCSpa benefits our health greatly.

 

2)
What is free radical?

The
free radical theory is an age theory commonly accepted in the science circle. The oxygen we take in has an oxidization effect
which produces the detrimental free radicals. Environment pollution, ultraviolet radiation, smoking, pesticide, ozone, alcohol
and many chemical drugs will also increase the amount of free radicals within our body, and aging and ailments are thus caused.

 

3)
How does OPCSpa fight free radicals?

Free
radical is one of the key causes for aging and many conditions. It is estimated that around 80% to 90% age or degeneration related
diseases have something to do with free radicals, including senile dementia, Parkinson’s Disease, skin spot, cataract, heart
disease, and cancer. Therefore, to remove free radicals is key to maintain a healthy and young body.

 

4)
How does OPCSpa protects the skin?

The
proanthocyanidin in OPCSpa restores the damaged collagens and elastin fibers, and the damage of these two substances is a key
factor that causes wrinkles and slackened muscles on the face. Many high-end cosmetics on the market, such as eye creams and sun
blocks contain proan- thocyanidin in order to protect the skin against ul- traviolet radiation and the formation of wrinkles.

 

    	 

    	 

    

 

生物高科技-細胞小分子營養食品
Bio-tech Micro Molecules Nutrition Supplement

 

5)
Is it safe to take OPCSpa?

OPCSpa
is a safe diet supplement for your health and is free from any toxic effect. The Pasteur Institute of France and the Cytotest
Cell Research of Germany both conducted a thorough study on proanthocyanidin, and proved it is as safe as Vi- tamin C.

 

6)
Is it enough to eat grape seeds?

Grape
seed is not tasty and is difficult for the digestion system. Most will be discharged from the body with the excrement, so experts
suggest that the grape seeds be grounded, boiled with water for ten minutes and taken. But you will only see the effects after
taking in large amounts of such

grape
seed water.

 

7) How long will
the OPCSpa effects show up?

Most customers see
pronounced effects of OPC- Spa in preventing allergy and improving immunity. However, to improve your skin conditions, it re-
quires a continued administration of three to six months to see a good result (the period may differ depending on different conditions
of individuals).

 

8)
What benefits can OPCSpa bring?

OPCSpa
delays aging, improves sight, helps bruises to heal, prevents cancer, reduces the risk of phlebitis and arthritis, prevents prostate
con- ditions, alleviates inflammations resulted from sports activities, improves the sexual functions, energizes, improves the
functions of the circula- tion system, prevents the worsening of psycholog- ical conditions, reduces the risk of heart diseases,
prevents strokes, improves the immunity system, improves allergic conditions, eases fatigue, and prevents cold and flu. Use it
before your aging process begins, so that it will help remove your wrinkles and keep your skin supple and smooth. In addition,
OPCSpa is also effective in prevent- ing and improving conditions associated with hay fever.

 

Based
on reports by Researcher Proto F,Carloni C.Meucci B,et al information from other research- ers.

 

[1] Haslam E.Plant polyphenols
[J] .Cambridge University Press.1989,14~15

[2] Masquelier J,Michaud
J,Laparra J,et al.Intrenat [J] .J Vit Nutr Res,1979,49:30

[3] D.Bagchi,et al.Protection
effects of grape seed proan- thocyanidins and selected antioxidant against TPA-Induced hepatic and brain lipid peroxidation and
DNA fragmentation, and peritoneal macrophage activation in mice [J]. Gen. Phar- mac, 1998,30(5):771~776

[4] Bombardelli E. [Z]
GB-1,541,549

[5] Indena.S P A.Internal
Report(Data on file) [Z]

[6] DA siva R J M,Rigaud
J,Cheynier V,et al. [J]. Phytochem- istry,1991,30:1259

[7] Lawrence J P,Liana
N.Hrstich and bock G [J].Chan Phyto- chemistry,1986,25:223

[8] D Bagchi,et al.Oxygen
free radical scavenging abilities of Vitamins C and Vitamins E,and a grape seed proanthocyani- dins extract in vitro research [J].Communications
in Molecular Pathology and Pharmacology, 1997, 95 ( 2 ):179~189

[9] Barbier A,Maffrand
J P.Savi P. in: Endotelonet unite circu- latoire [M].John Libbey (Ed.) Paris - London,1988,39~41

[10] Doutremepuich J D,Baibier
A,Lacheretz F. [Z].Lymphol- ogy,1991,24:135

[11] Ross R. [J].Nature,1993,362:801

[12] Preuss HG,et al.Chromium,Zinc,and
Grape seed extract(Flavonoids) can overcome age-related increases in SPB normotensive rats [J] .Journal of the American College
of Nutrition,1997,16(5):43

[13] S S Joshi,et al.Cytotoxicity
of a novel grape seed proan- thocyanidins extract against elected human cancer cells [R].Second International conference on Natural
Antioxidant and

Disease June 24~27,1998,Helsinki,
Finland

[14] M Bagchi,et al.Comparative
protective abilities of Vitamins C and E and a grape seed proanthocyanidins extract(GSPE) on smokeless tobacco-induced oxidative
stress and apop- topic cell death in Human Oral keratinocytes [J] .Toxicological Sciences, 1998,922:187

[15] Marmiroli A,Restivo
F M,Donnini C,et al. [Z] Molec.Gen. Genet.177,581,1980

[16] Magni G E,von Borstel
R C. [Z] . Genetics. 47,1097,1962 [17] Puglisi P P. [Z] Molec. Gen. Genet. 103,248,1968

[18] Godeau R G,Gavignet-jeannin
G,Groult N,et al. [J] . Path. Biol,38,608,1990

[19] Fusi L,Czimeg F,Pesce
F,et al. [Z] .Ann Ott ClinOcul.114,575,1998

[20] Moriconi S,Bellezza
P G. [Z] .Ann Ott ClinOcul.114,585,1998

[21] Proto F,Carloni C.Meucci
B,et al. [Z] Ann Ott ClinOcul.114,85,1998

 

[Manufacturer]
Made in U.S.A

[Specification]
60 capsules/bottle, 500mg/capsule

[Shelf
life] 2 years

[Caution]
This product cannot replace medication

 

*These
statements have not been evaluated by the Food and Drug Administration. This product is not in- tended to diagnose, treat, cure
or prevent any disease.

 

		This product shall be stored at a room temperature (below 26°C or 80°F). The shelf life for this product is two years. Other matters requiring attention:
	 ̇ Not to expose to high temperature.  ̇Not to be placed under the sun or in the overheated trunk.  ̇Not to store it in the refrigerator.  ̇To tighten the lid after opening, and to finish using the bottle within 45 days.   ̇Please check the product before purchasing. The product is not returnable nor exchangeable after purchase because it is undeterminable whether the cus- tomer has placed it under high temperature.

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