Document:

Lease Agreement - Metropolitan Life Insurance Company

  
 Exhibit 10.8 

 
  
  

 
  
  

 
  
 LEASE

 BETWEEN 
 METROPOLITAN
LIFE INSURANCE COMPANY (LANDLORD) 
 AND 
 ACELRX PHARMACEUTICALS, INC. (TENANT) 
 SEAPORT CENTRE 

Redwood City, California 

  
 TABLE OF CONTENTS 

 

					
	 	  	 	  	PAGE
		
	 ARTICLE ONE - BASIC LEASE PROVISIONS
	  	1
	 1.01
	  	 BASIC LEASE PROVISIONS
	  	1
	 1.02
	  	 ENUMERATION OF EXHIBITS & RIDER(S)
	  	2
	 1.03
	  	 DEFINITIONS
	  	2
		
	 ARTICLE TWO - PREMISES, TERM, FAILURE TO GIVE POSSESSION, COMMON AREAS AND PARKING
	  	6
	 2.01
	  	 LEASE OF PREMISES
	  	6
	 2.02
	  	 TERM
	  	6
	 2.03
	  	 FAILURE TO GIVE POSSESSION
	  	6
	 2.04
	  	 AREA OF PREMISES
	  	6
	 2.05
	  	 CONDITION OF PREMISES
	  	6
	 2.06
	  	 COMMON AREAS & PARKING
	  	6
		
	 ARTICLE THREE - RENT
	  	7
		
	 ARTICLE FOUR - OPERATING EXPENSES RENT ADJUSTMENTS AND PAYMENTS
	  	7
	 4.01
	  	 TENANT’S SHARE OF OPERATING EXPENSES
	  	7
	 4.02
	  	 RENT ADJUSTMENTS
	  	8
	 4.03
	  	 STATEMENT OF LANDLORD
	  	8
	 4.04
	  	 BOOKS AND RECORDS
	  	8
	 4.05
	  	 TENANT OR LEASE SPECIFIC TAXES
	  	9
		
	 ARTICLE FIVE - SECURITY
	  	9
		
	 ARTICLE SIX -UTILITIES & SERVICES
	  	10
	 6.01
	  	 LANDLORD’S GENERAL SERVICES
	  	10
	 6.02
	  	 TENANT TO OBTAIN & PAY DIRECTLY
	  	10
	 6.03
	  	 TELEPHONE SERVICES
	  	10
	 6.04
	  	 FAILURE OR INTERRUPTION OF UTILITY OR SERVICE
	  	11
	 6.05
	  	 CHOICE OF SERVICE PROVIDER
	  	11
	 6.06
	  	 SIGNAGE
	  	11
		
	 ARTICLE SEVEN - POSSESSION, USE AND CONDITION OF PREMISES
	  	11
	 7.01
	  	 POSSESSION AND USE OF PREMISES
	  	11
	 7.02
	  	 HAZARDOUS MATERIAL
	  	12
	 7.03
	  	 LANDLORD ACCESS TO PREMISES; APPROVALS
	  	13
	 7.04
	  	 QUIET ENJOYMENT
	  	14
		
	 ARTICLE EIGHT - MAINTENANCE
	  	14
	 8.01
	  	 LANDLORD’S MAINTENANCE
	  	14
	 8.02
	  	 TENANT’S MAINTENANCE
	  	14
		
	 ARTICLE NINE - ALTERATIONS AND IMPROVEMENTS
	  	14
	 9.01
	  	 TENANT ALTERATIONS
	  	14
	 9.02
	  	 LIENS
	  	15
		
	 ARTICLE TEN - ASSIGNMENT AND SUBLETTING
	  	15
	 10.01
	  	             ASSIGNMENT AND SUBLETTING
	  	15
	 10.02
	  	             RECAPTURE
	  	17
	 10.03
	  	             EXCESS RENT
	  	17
	 10.04
	  	             TENANT LIABILITY
	  	17
	 10.05
	  	             ASSUMPTION AND ATTORNMENT
	  	17
		
	 ARTICLE ELEVEN - DEFAULT AND REMEDIES
	  	17
	 11.01
	  	             EVENTS OF DEFAULT
	  	17
	 11.02
	  	             LANDLORD’S REMEDIES
	  	18
	 11.03
	  	             ATTORNEY’S FEES
	  	19
	 11.04
	  	             BANKRUPTCY
	  	19
	 11.05
	  	             LANDLORD’S DEFAULT
	  	20
		
	 ARTICLE TWELVE - SURRENDER OF PREMISES
	  	20
	 12.01
	  	             IN GENERAL
	  	20
	 12.02
	  	             LANDLORD’S RIGHTS
	  	20
		
	 ARTICLE THIRTEEN - HOLDING OVER
	  	21

  
 i 

  

							
	 ARTICLE FOURTEEN - DAMAGE BY FIRE OR OTHER CASUALTY
	  	 	21	  
	 14.01
	  	             SUBSTANTIAL UNTENANTABILITY
	  	 	21	  
	 14.02
	  	             INSUBSTANTIAL UNTENANTABILITY
	  	 	22	  
	 14.03
	  	             RENT ABATEMENT
	  	 	22	  
	 14.04
	  	             WAIVER OF STATUTORY REMEDIES
	  	 	22	  
		
	 ARTICLE FIFTEEN - EMINENT DOMAIN
	  	 	22	  
	 15.01
	  	             TAKING OF WHOLE OR SUBSTANTIAL PART
	  	 	22	  
	 15.02
	  	             TAKING OF PART
	  	 	22	  
	 15.03
	  	             COMPENSATION
	  	 	23	  
		
	 ARTICLE SIXTEEN - INSURANCE
	  	 	23	  
	 16.01
	  	             TENANT’S INSURANCE
	  	 	23	  
	 16.02
	  	             FORM OF POLICIES
	  	 	23	  
	 16.03
	  	             LANDLORD’S INSURANCE
	  	 	23	  
	 16.04
	  	             WAIVER OF SUBROGATION
	  	 	23	  
	 16.05
	  	             NOTICE OF CASUALTY
	  	 	24	  
		
	 ARTICLE SEVENTEEN - WAIVER OF CLAIMS AND INDEMNITY
	  	 	24	  
	 17.01
	  	             WAIVER OF CLAIMS
	  	 	24	  
	 17.02
	  	             INDEMNITY BY TENANT
	  	 	24	  
	 17.03
	  	             WAIVER OF CONSEQUENTIAL DAMAGES
	  	 	25	  
		
	 ARTICLE EIGHTEEN - RULES AND REGULATIONS
	  	 	25	  
	 18.01
	  	             RULES
	  	 	25	  
	 18.02
	  	             ENFORCEMENT
	  	 	25	  
		
	 ARTICLE NINETEEN - LANDLORD’S RESERVED RIGHTS
	  	 	25	  
		
	 ARTICLE TWENTY - ESTOPPEL CERTIFICATE
	  	 	25	  
	 20.01
	  	             IN GENERAL
	  	 	25	  
	 20.02
	  	             ENFORCEMENT
	  	 	26	  
		
	 ARTICLE TWENTY-ONE – INTENTIONALLY OMITTED
	  	 	26	  
		
	 ARTICLE TWENTY-TWO - REAL ESTATE BROKERS
	  	 	26	  
		
	 ARTICLE TWENTY-THREE - MORTGAGEE PROTECTION
	  	 	26	  
	 23.01
	  	             SUBORDINATION AND ATTORNMENT
	  	 	26	  
	 23.02
	  	             MORTGAGEE PROTECTION
	  	 	26	  
		
	 ARTICLE TWENTY-FOUR - NOTICES
	  	 	27	  
		
	 ARTICLE TWENTY-FIVE - EXERCISE FACILITY
	  	 	27	  
		
	 ARTICLE TWENTY-SIX - MISCELLANEOUS
	  	 	27	  
	 26.01
	  	             LATE CHARGES
	  	 	27	  
	 26.02
	  	             NO JURY TRIAL; VENUE; JURISDICTION
	  	 	28	  
	 26.03
	  	             DEFAULT UNDER OTHER LEASE
	  	 	28	  
	 26.04
	  	             OPTION
	  	 	28	  
	 26.05
	  	             AUTHORITY
	  	 	28	  
	 26.06
	  	             ENTIRE AGREEMENT
	  	 	28	  
	 26.07
	  	             MODIFICATION OF LEASE FOR BENEFIT OF MORTGAGEE
	  	 	28	  
	 26.08
	  	             EXCULPATION
	  	 	28	  
	 26.09
	  	             ACCORD AND SATISFACTION
	  	 	28	  
	 26.10
	  	             LANDLORD’S OBLIGATIONS ON SALE OF BUILDING
	  	 	29	  
	 26.11
	  	             BINDING EFFECT
	  	 	29	  
	 26.12
	  	             CAPTIONS
	  	 	29	  
	 26.13
	  	             TIME; APPLICABLE LAW; CONSTRUCTION
	  	 	29	  
	 26.14
	  	             VACATION
	  	 	29	  
	 26.15
	  	             LANDLORD’S RIGHT TO PERFORM TENANT’S
DUTIES
	  	 	29	  
	 26.16
	  	             SECURITY SYSTEM
	  	 	29	  
	 26.17
	  	             NO LIGHT, AIR OR VIEW EASEMENTS
	  	 	29	  
	 26.18
	  	             RECORDATION
	  	 	29	  
	 26.19
	  	             SURVIVAL
	  	 	29	  
	 26.20
	  	             EXHIBITS OR RIDERS
	  	 	30	  

  
 ii 

  
 LEASE 

ARTICLE ONE 
 BASIC LEASE PROVISIONS

  

	1.01	BASIC LEASE PROVISIONS 

 In the event of any conflict between these
Basic Lease Provisions and any other Lease provision, such other Lease provision shall control. 
  

	(1)	BUILDING AND ADDRESS: Building Number 3, located in Phase I (“Tenant’s Phase”) of Seaport Centre. As of the Lease Date, the Building includes the address 575
Chesapeake Drive and other street address(es) in Redwood City, California, 94063. 

  

	(2)	LANDLORD AND ADDRESS: 

 Metropolitan Life Insurance
Company, 
 a New York corporation 
 Notices to Landlord shall be addressed: 
 Metropolitan Life Insurance Company 

c/o Seaport Centre Manager 
 701
Chesapeake Drive 
 Redwood City, CA 94063 
 with copies to the following: 
 Metropolitan Life Insurance Company 

400 South El Camino Real, 8th Floor 
 San
Mateo, CA 94402 
 Attention: Director, EIM 
 and 
 Metropolitan Life Insurance Company 

400 South El Camino Real, 8th Floor 
 San
Mateo, CA 94402 
 Attention: Associate General Counsel 
  

	(3)	TENANT; CURRENT ADDRESS and TAX ID: 

  

					
	 (a)	  	Name:	  	AcelRx Pharmaceuticals, Inc.
	 (b)	  	State of incorporation:	  	a Delaware corporation
	 (c)	  	Tax Identification Number:	  	41-2193603

 Tenant shall notify Landlord of any change in the
foregoing. 
 Notices to Tenant shall be addressed: 
  

			
	Prior to Commencement Date:	  	On & After Commencement Date:
		
	AcelRx Pharmaceuticals, Inc.	  	AcelRx Pharmaceuticals, Inc.
	c/o Regus, 6th
Floor	  	575 Chesapeake Drive
	303 Twin Dolphin Drive	  	Redwood City, CA 94063
	Redwood City, CA 94063	  	Attention: Carter King
	 Attention: Carter King
	  	

  

	(4)	DATE OF LEASE: as of January 2, 2007 

  

	(5)	LEASE TERM: Sixty (60) months 

  

	(6)	COMMENCEMENT DATE: See Rider 2. 

  

	(7)	PROJECTED EXPIRATION DATE: The day before the fifth anniversary of the Commencement Date. 

  
 1 

  

	(8)	MONTHLY BASE RENT (initial monthly installment due upon Tenant’s execution): 

  

							
	 Period from/to
	  	 Monthly
	 	  	 Monthly Rate/SF of Rentable Area

			
	 Months 01-12
	  	$	26,001.50	  	  	$2.30
	 Months 13-24
	  	$	26,781.55	  	  	$2.37
	 Months 25-36
	  	$	27,596.64	  	  	$2.44
	 Months 37-48
	  	$	28,411.73	  	  	$2.51
	 Months 49-60
	  	$	29,226.82	  	  	$2.59

 (9)      RENT ADJUSTMENT
DEPOSIT (initial monthly rate, until further notice): $6,556.90 (initial monthly installment due upon Tenant’s execution) 
  

	(10)	 RENTABLE AREA OF THE PREMISES: 11,305 square feet 

  

	(11)    	RENTABLE AREA OF THE BUILDING:    37,856 square feet 

  

	(12)    	RENTABLE AREA OF THE PHASE:       301,824 square feet 

 

	(13)    	RENTABLE AREA OF THE PROJECT:    537,444 square feet 

  

	(14)    	SECURITY: The cash in the amount of Thirty Thousand Dollars ($30,000) and Letter of Credit in the amount of One Hundred Fifty Thousand Dollars ($150,000) (and all proceeds of the
Letter of Credit drawn and held by Landlord) as provided in Article Five. 

  

	(15)    	SUITE NUMBER &/OR ADDRESS OF PREMISES: 575 Chesapeake Drive, Redwood City, CA 94063 

 

	(16)    	TENANT’S SHARE: 

  

			
	 Tenant’s Building Share:
	  	29.8632%
	 Tenant’s Phase Share:
	  	03.7456%
	 Tenant’s Project Share:
	  	02.1035%

  

	(17)	TENANT’S USE OF PREMISES: General office use; labs for pharmaceutical purposes; and engineering lab. For purposes of this Lease, “engineering lab” shall mean a
light mechanical workspace (not a machine shop) for use of hand tools, some small equipment (but not heavy equipment or machinery or lathes), some soldering and some adhesives incidental to Tenant’s pharmaceutical labs and products and to
general office use. 

  

	(18)	PARKING
SPACES:                             Thirty-Seven (37) 

 

	(19)	BROKERS: 

   Landlord’s
Broker:             Kristoph Lodge and Howard Dallmar of Cornish & Carey Commercial 
   Tenant’s Broker:                Randy Scott of Cornish & Carey Commercial 

 

	1.02	      ENUMERATION OF EXHIBITS & RIDER(S) 

 The Exhibits and Rider(s) set forth below and attached to this Lease are incorporated in this Lease by this reference: 
  

			
	 EXHIBIT A
	  	Plan of Premises
	 EXHIBIT B
	  	Workletter Agreement
	 EXHIBIT C
	  	Site Plan of Project
	 EXHIBIT D 
	  	Permitted Hazardous Material
	 EXHIBIT E
	  	Form of Letter of Credit
		
	 RIDER 1
	  	Commencement Date Agreement
	RIDER 2	  	Additional Provisions

  

	1.03      	DEFINITIONS 

 For purposes hereof, the following terms shall have
the following meanings: 
 ADJUSTMENT YEAR: The applicable calendar year or any portion thereof after the Commencement Date of this Lease for which a Rent
Adjustment computation is being made. 
 AFFILIATE: Any Person (as defined below) which is controlled by, controls, or is under common control with
Tenant. The word Person means an individual, partnership, trust, corporation, limited liability company, firm or other entity. For purposes of this definition, the word “control,” means, with respect to a Person that is a corporation or a
limited liability company, the right to exercise, directly or indirectly, more than fifty percent (50%) of the voting rights attributable to the shares or membership interests of the controlled Person and, with respect to a Person that is not

  
 2 

 
a corporation, the possession, directly or indirectly, of the power at all times to direct or cause the direction of the management of the controlled Person. 

BUILDING: Each building in which the Premises is located, as specified in Section 1.01(1). 
 BUILDING OPERATING EXPENSES: Those Operating Expenses described in Section 4.01. 
 COMMENCEMENT DATE: The date
determined as set forth in Rider 2. 
 COMMON AREAS: All areas of the Project made available by Landlord from time to time for the general common use or
benefit of the tenants of the Building or Project, and their employees and invitees, or the public, as such areas currently exist and as they may be changed from time to time. 
 DECORATION: Tenant Alterations which do not require a building permit and which do not affect the facade or roof of the Building, or involve any of the structural elements of the Building, or involve any of the
Building’s systems, including its electrical, mechanical, plumbing, security, heating, ventilating, air-conditioning, communication, and fire and life safety systems. 
 DEFAULT RATE: Two (2) percentage points above the rate then most recently announced by Bank of America N.T. & S.A. at its San Francisco main office as its corporate base lending rate, from time to
time announced, but in no event higher than the maximum rate permitted by Law. 
 DELIVERY DATE: The date for Landlord’s delivery to Tenant of
possession of the Premises, if different from the Commencement Date, as provided in Rider 2. 
 ENVIRONMENTAL LAWS: All Laws governing the use, storage,
transportation, disposal or generation of any Hazardous Material, or pertaining to environmental conditions on, under or about the Premises or any part of the Project, including the Comprehensive Environmental Response Compensation and Liability Act
of 1980 (42 U.S.C. Section 9601 et seq.), the Resource Conservation and Recovery Act of 1976 (42 U.S.C. Section 6901 et seq.), the Hazardous Materials Transportation Act (49 U.S.C. Section 1801, et seq.); and Section 307 (33
U.S.C. Section 1317) and Section 311 (33 U.S.C. Section 1321) of the Clean Water Act of 1977 (33 U.S.C. Section 1251, et seq.), all as heretofore or hereafter amended. 
 EXPIRATION DATE: The date specified in Section 1.01(7) unless changed by operation of Article Two. 
 FORCE
MAJEURE: Any accident, casualty, act of God, war or civil commotion, strike or labor troubles, or any cause whatsoever beyond the reasonable control of Landlord, including water shortages, energy shortages or governmental preemption in connection
with an act of God, a national emergency, or by reason of Law, or by reason of the conditions of supply and demand which have been or are affected by act of God, war or other emergency. 
 HAZARDOUS MATERIAL: Such substances, material and wastes which are or become regulated under any Law pertaining to environmental conditions, or which are classified as hazardous, toxic, medical waste or
bio-hazardous waste under any Law; and explosives, firearms, ammunition, flammable materials, radioactive material, asbestos, polychlorinated biphenyls, acids, caustics, gasoline, kerosene, natural gas, propane, oil, petroleum, petroleum products
and by-products. Hazardous Material shall include by way of illustration, and without limiting the generality of the foregoing, the following: (i) those substances included within the definitions of “hazardous substances,”
“hazardous materials,” “toxic substances” or “solid waste” under all present and future Laws relating to the protection of human health or the environment, including California Senate Bill 245 (Statutes of 1987, Chapter
1302); the Safe Drinking Water and Toxic Enforcement Act of 1986 (commonly known as Proposition 65); the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (42 U.S.C. Section 9601 et seq.); the Resource Conservation
and Recovery Act of 1976 (42 U.S.C. Section 6901 et seq.); the Hazardous Materials Transportation Act (49 U.S.C. Sections 1801, et seq.); Section 307 (33 U.S.C. Section 1317) or Section 311 (33 U.S.C. Section 1321) of the
Clean Water Act of 1977 (33 U.S.C. Section 1251, et seq.), all as heretofore and hereafter amended, or in any regulations promulgated pursuant to said laws; (ii) those substances defined as “hazardous wastes” in
Section 25117 of the California Health & Safety Code or as “hazardous substances” in Section 25316 of the California Health & Safety Code, all as heretofore and hereafter amended, or in any regulations
promulgated pursuant to said laws; (iii) those substances listed in the United States Department of Transportation Table (49 CFR 172.101 and amendments thereto) or designated by the Environmental Protection Agency (or any successor agency) as
hazardous substances (see, e.g., 40 CFR Part 302 and amendments thereto); and (iv) such other substances, materials and wastes which are or become regulated under applicable local, state or federal law or by the United States government or
which are or become classified as hazardous or toxic under federal, state or local laws or regulations, including California Health & Safety Code, Division 20, and Title 26 of the California Code of Regulations, all as heretofore and
hereafter amended, or in any regulations promulgated pursuant to said laws. 
 INDEMNITEES: Collectively, Landlord, any Mortgagee or ground lessor of the
Property, the property manager and the leasing manager for the Property and their respective directors, officers, agents and employees. 
 LAND: The
parcel(s) of real estate on which the Building and Project are located. 
 LANDLORD WORK: The construction or installation of improvements to be furnished
by Landlord, if any, specifically described in Rider 2 attached hereto. 
 LAWS OR LAW: All laws, ordinances, rules, regulations, other requirements,
orders, rulings or decisions adopted or made by any governmental body, agency, department or judicial authority having jurisdiction over the Property, 

  
 3 

 
the Premises or Tenant’s activities at the Premises and any covenants, conditions or restrictions of record which affect the Property, all as heretofore or hereafter adopted, made or
amended. 
 LEASE: This instrument and all exhibits and riders attached hereto, as may be amended from time to time. 

LEASE YEAR: The twelve month period beginning on the first day of the first month following the Commencement Date (unless the Commencement Date is the first day of
a calendar month in which case beginning on the Commencement Date), and each subsequent twelve month, or shorter, period until the Expiration Date. 

MONTHLY BASE RENT: The monthly rent specified in Section 1.01(8). 
 MORTGAGEE: Any holder of a mortgage, deed of trust or other security instrument encumbering the Property. 
 NATIONAL
HOLIDAYS: New Year’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day and Christmas Day and other holidays recognized by the Landlord and the janitorial and other unions servicing the Building in accordance with their contracts.

 OPERATING EXPENSES: All Taxes, costs, expenses and disbursements of every kind and nature which Landlord shall pay or become obligated to pay in
connection with the ownership, management, operation, maintenance, replacement and repair of the Property (including the amortized portion of any capital expenditure or improvement, together with interest thereon, expenses of changing utility
service providers, and any dues, assessments and other expenses pursuant to any covenants, conditions and restrictions, or any reciprocal easements, or any owner’s association now or hereafter affecting the Project). Operating Expenses shall be
allocated among the categories of Project Operating Expenses, Building Operating Expenses or Phase Operating Expenses as provided in Article Four. If any Operating Expense, though paid in one year, relates to more than one calendar year, at the
option of Landlord such expense may be proportionately allocated among such related calendar years. Operating Expenses shall include the following, by way of illustration only and not limitation: (1) all Taxes; (2) all insurance premiums
and other costs (including deductibles), including the cost of rental insurance; (3) all license, permit and inspection fees; (4) all costs of utilities, fuels and related services, including water, sewer, light, telephone, power and steam
connection, service and related charges; (5) all costs to repair, maintain and operate heating, ventilating and air conditioning systems, including preventive maintenance; (6) all janitorial, landscaping and security services; (7) all
wages, salaries, payroll taxes, fringe benefits and other labor costs, including the cost of workers’ compensation and disability insurance; (8) all costs of operation, maintenance and repair of all parking facilities and other common
areas; (9) all supplies, materials, equipment and tools; (10) dues, assessments and other expenses pursuant to any covenants, conditions and restrictions, or any reciprocal easements, or any owner’s association now or hereafter
affecting the Project; (11) modifications to the Building or the Project occasioned by Laws now or hereafter in effect; (12) the total charges of any independent contractors employed in the care, operation, maintenance, repair, leasing and
cleaning of the Project, including landscaping, roof maintenance, and repair, maintenance and monitoring of life-safety systems, plumbing systems, electrical wiring and Project signage; (13) the cost of accounting services necessary to compute
the rents and charges payable by tenants at the Project; (14) exterior window and exterior wall cleaning and painting; (15) managerial and administrative expenses; (16) all costs in connection with the exercise facility at the
Project; (17) all costs and expenses related to Landlord’s retention of consultants in connection with the routine review, inspection, testing, monitoring, analysis and control of Hazardous Material, and retention of consultants in
connection with the clean-up of Hazardous Material (to the extent not recoverable from a particular tenant of the Project), and all costs and expenses related to the implementation of recommendations made by such consultants concerning the use,
generation, storage, manufacture, production, storage, release, discharge, disposal or clean-up of Hazardous Material on, under or about the Premises or the Project (to the extent not recoverable from a particular tenant of the Project);
(18) all capital improvements made for the purpose of reducing or controlling other Operating Expenses, and all other capital expenditures, but in each case of any capital item the cost of which exceeds double the then monthly installment of
the Rent Adjustment Deposit, only as amortized over the useful life of such capital item as reasonably determined by Landlord, together with interest on the unamortized portion; (19) all property management costs and fees, including all costs
in connection with the Project property management office; and (20) all fees or other charges incurred in conjunction with voluntary or involuntary membership in any energy conservation, air quality, environmental, traffic management or similar
organizations. Operating Expenses shall not include: (a) costs of alterations of space to be occupied by new or existing tenants of the Project; (b) depreciation charges; (c) interest and principal payments on loans (except for loans
for capital expenditures or improvements which Landlord is allowed to include in Operating Expenses as provided above); (d) ground rental payments; (e) real estate brokerage and leasing commissions; (f) advertising and marketing
expenses; (g) costs of Landlord reimbursed by insurance proceeds; (h) expenses incurred in negotiating leases of other tenants in the Project or enforcing lease obligations of other tenants in the Project; and (i) Landlord’s or
Landlord’s property manager’s corporate general overhead or corporate general administrative expenses. 
 PHASE: Phase means any individual
Phase of the Project, as more particularly described in the definition of Project. 
 PHASE OPERATING EXPENSES: Those Operating Expenses described in
Section 4.01. 
 PREMISES: The space located in the Building at the Suite Number listed in Section 1.01(15) and depicted on Exhibit A
attached hereto. 
 PROJECT or PROPERTY: As of the date hereof, the Project is known as Seaport Centre and consists of those buildings (including the
Building) whose general location is shown on the Site Plan of the Project attached as Exhibit C, located in Redwood City, California, associated vehicular and parking areas, landscaping and improvements, together with the Land, any associated
interests in real property, and the personal property, fixtures, machinery, equipment, systems and apparatus located in or used in conjunction with any of the foregoing. The Project may 

  
 4 

 
also be referred to as the Property. As of the date hereof, the Project is divided into Phase I and Phase II, which are generally designated on Exhibit C, each of which may individually be
referred to as a Phase. Landlord reserves the right from time to time to add or remove buildings, areas and improvements to or from a Phase or the Project, or to add or remove a Phase to or from the Project. In the event of any such addition or
removal which affects Rentable Area of the Project or a Phase, Landlord shall make a corresponding recalculation and adjustment of any affected Rentable Area and Tenant’s Share. 
 PROJECT OPERATING EXPENSES: Those Operating Expenses described in Section 4.01. 
 REAL PROPERTY: The Property
excluding any personal property. 
 RENT: Collectively, Monthly Base Rent, Rent Adjustments and Rent Adjustment Deposits, and all other charges, payments,
late fees or other amounts required to be paid by Tenant under this Lease. 
 RENT ADJUSTMENT: Any amounts owed by Tenant for payment of Operating
Expenses. The Rent Adjustments shall be determined and paid as provided in Article Four. 
 RENT ADJUSTMENT DEPOSIT: An amount equal to Landlord’s
estimate of the Rent Adjustment attributable to each month of the applicable Adjustment Year. On or before the Commencement Date and the beginning of each subsequent Adjustment Year or with Landlord’s Statement (defined in Article Four),
Landlord may estimate and notify Tenant in writing of its estimate of Operating Expenses, including Project Operating Expenses, Building Operating Expenses and Phase Operating Expenses, and Tenant’s Share of each, for the applicable Adjustment
Year. The Rent Adjustment Deposit applicable for the calendar year in which the Commencement Date occurs shall be the amount, if any, specified in Section 1.01(9). Landlord shall have the right from time to time during any Adjustment Year to
provide a new or revised estimate of Operating Expenses and/or Taxes and to notify Tenant in writing thereof, of corresponding adjustments in Tenant’s Rent Adjustment Deposit payable over the remainder of such year, and the amount or revised
amount due allocable to months preceding such change. The last estimate by Landlord shall remain in effect as the applicable Rent Adjustment Deposit unless and until Landlord notifies Tenant in writing of a change. 

RENTABLE AREA OF THE BUILDING: The amount of square footage set forth in Section 1.01(11) 
 RENTABLE AREA OF THE PHASE: The amount of square footage set forth in Section 1.01(12) 
 RENTABLE AREA OF THE
PREMISES: The amount of square footage set forth in Section 1.01(10). 
 RENTABLE AREA OF THE PROJECT: The amount of square footage set forth in
Section 1.01(13), which represents the sum of the rentable area of all space intended for occupancy in the Project. 
 SECURITY: The cash and Letter
of Credit specified in Section 1.01 as Security paid and/or delivered to Landlord as security for Tenant’s performance of its obligations under this Lease, and all proceeds of the Letter of Credit drawn and held by Landlord, all as more
particularly provided in Article Five. 
 SUBSTANTIALLY COMPLETE or SUBSTANTIAL COMPLETION: The completion of the Landlord Work or Tenant Work, as the
case may be, except for minor insubstantial details of construction, decoration or mechanical adjustments which remain to be done. 
 TAXES: All federal,
state and local governmental taxes, assessments (including assessment bonds) and charges of every kind or nature, whether general, special, ordinary or extraordinary, which Landlord shall pay or become obligated to pay because of or in connection
with the ownership, leasing, management, control or operation of the Property or any of its components (including any personal property used in connection therewith), which may also include any rental or similar taxes levied in lieu of or in
addition to general real and/or personal property taxes. For purposes hereof, Taxes for any year shall be Taxes which are assessed for any period of such year, whether or not such Taxes are billed and payable in a subsequent calendar year. There
shall be included in Taxes for any year the amount of all fees, costs and expenses (including reasonable attorneys’ fees) paid by Landlord during such year in seeking or obtaining any refund or reduction of Taxes. Taxes for any year shall be
reduced by the net amount of any tax refund received by Landlord attributable to such year. If a special assessment payable in installments is levied against any part of the Property, Taxes for any year shall include only the installment of such
assessment and any interest payable or paid during such year. Taxes shall not include any federal or state inheritance, general income, gift or estate taxes, except that if a change occurs in the method of taxation resulting in whole or in part in
the substitution of any such taxes, or any other assessment, for any Taxes as above defined, such substituted taxes or assessments shall be included in the Taxes. 
 TENANT ADDITIONS: Collectively, Landlord Work, Tenant Work and Tenant Alterations. 
 TENANT ALTERATIONS: Any
alterations, improvements, additions, installations or construction in or to the Premises or any Real Property systems serving the Premises done or caused to be done by Tenant after the date hereof, whether prior to or after the Commencement Date
(including Tenant Work, but excluding Landlord Work). 
 TENANT DELAY: Any event or occurrence which delays the Substantial Completion of the Landlord
Work which is caused by or is described as follows: 
 (i) special work, changes, alterations or additions requested or made by Tenant in
the design or finish in any part of the Premises after approval of the plans and specifications (as described in the Rider 2); 

  
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 (ii) Tenant’s delay in
submitting plans, supplying information, approving plans, specifications or estimates, or giving authorizations; 
 (iii) failure to
approve and pay for such work, if any, as Landlord undertakes to complete at Tenant’s expense; 
 (iv) the performance or completion
by Tenant or any person engaged by Tenant of any work in or about the Premises; or 
 (v) failure to perform or comply with any obligation
or condition binding upon Tenant pursuant to Rider 2, including the failure to approve and pay for such Landlord Work or other items if and to the extent Rider 2 provides they are to be approved or paid by Tenant. 

TENANT WORK: All work installed or furnished to the Premises by Tenant in connection with Tenant’s initial occupancy pursuant to Rider 2 and the Workletter,
including those items described in Section 5 of the Workletter as part of the Tenant Work. 
 TENANT’S BUILDING SHARE: The share as specified in
Section 1.01(16) and Section 4.01. 
 TENANT’S PHASE: The Phase in which the Premises is located, as indicated in Section 1.01(1).

 TENANT’S PHASE SHARE: The share as specified in Section 1.01(16) and Section 4.01. 

TENANT’S PROJECT SHARE: The share as specified in Section 1.01(16) and Section 4.01. 
 TENANT’S SHARE: Shall mean collectively, Tenant’s respective shares of the respective categories of Operating Expenses, as provided in Section 1.01(16) and Section 4.01. If this Lease is of
Premises in more than one building of the Project, then Tenant’s Building Share shall be calculated and specified separately for each such building. 

TERM: The term of this Lease commencing on the Commencement Date and expiring on the Expiration Date. 
 TERMINATION DATE: The Expiration Date or such earlier date as this Lease terminates or Tenant’s right to possession of the Premises terminates. 
 WORKLETTER: The agreement regarding the condition of the Premises and Building, and completion of Tenant Work and Landlord Work, if any, set forth in Rider 2 and/or Exhibit B hereto. 

ARTICLE TWO 
 PREMISES, TERM, FAILURE
TO GIVE POSSESSION, COMMON AREAS AND PARKING 
  

	2.01      	LEASE OF PREMISES 

 Landlord hereby leases to Tenant and Tenant
hereby leases from Landlord the Premises for the Term and upon the terms, covenants and conditions provided in this Lease. 
  

	2.02      	TERM (See Rider 2) 

  

	2.03      	FAILURE TO GIVE POSSESSION (See Rider 2) 

  

	2.04      	AREA OF PREMISES 

 Landlord and Tenant agree that for all purposes
of this Lease the Rentable Area of the Premises, the Rentable Area of the Building, the Rentable Area of the Phase and the Rentable Area of the Project as set forth in Article One are controlling, and are not subject to revision after the date of
this Lease, except as otherwise provided herein. 
  

	2.05      	CONDITION OF PREMISES (See Rider 2) 

  

	2.06      	COMMON AREAS & PARKING 

              (a)       Right to Use Common Areas.
Tenant shall have the non-exclusive right, in common with others, to the use of any common entrances, ramps, drives and similar access and serviceways and other Common Areas in the Project. The rights of Tenant hereunder in and to the Common Areas
shall at all times be subject to the rights of Landlord and other tenants and owners in the Project who use the same in common with Tenant, and it shall be the duty of Tenant to keep all the Common Areas free and clear of any obstructions created or
permitted by Tenant or resulting from Tenant’s operations. Tenant shall not use the Common Areas or common facilities of the Building or the Project, including the Building’s electrical room, parking lot or trash enclosures, for storage
purposes. Nothing herein shall affect the right of Landlord at any time to remove any persons not authorized to use the Common Areas or common facilities from such areas or facilities or to prevent their use by unauthorized persons. 

  (b)       Changes in Common Areas. Landlord reserves the right, at any time and from time to time
to (i) make alterations in or additions to the Common Areas or common facilities of the Project, including constructing new buildings or changing the location, size, shape or number of the driveways, entrances, parking spaces, parking areas,
loading and unloading areas, landscape areas and walkways, (ii) designate property to be included in or eliminate property from the Common Areas or common facilities of the Project, (iii) close temporarily any of the Common Areas or common
facilities of the Project for maintenance purposes, and (4) use the Common Areas and common facilities of the Project while engaged in making alterations in or additions and repairs to the Project; provided, however, that reasonable access to
the Premises and parking at or near the Project remains available. 

  
 6 

  

  (c)       Parking. During the Term, Tenant shall have the right to use the number of Parking Spaces
specified in Section 1.01(18) for parking on an unassigned basis on that portion of the Project designated by Landlord from time to time for parking. Tenant acknowledges and agrees that the parking spaces in the Project’s parking facility
may include a mixture of spaces for compact vehicles as well as full-size passenger automobiles, and that Tenant shall not use parking spaces for vehicles larger than the striped size of the parking spaces. Tenant shall not park any vehicles at the
Project overnight, except vehicles of employees traveling on Tenant’s business which may be parked no longer than two consecutive nights. Tenant shall comply with any and all parking rules and regulations if and as from time to time established
by Landlord. Tenant shall not allow any vehicles using Tenant’s parking privileges to be parked, loaded or unloaded except in accordance with this Section, including in the areas and in the manner designated by Landlord for such activities. If
any vehicle is using the parking or loading areas contrary to any provision of this Section, Landlord shall have the right, in addition to all other rights and remedies of Landlord under this Lease, to remove or tow away the vehicle without prior
notice to Tenant, and the cost thereof shall be paid to Landlord within ten (10) days after notice from Landlord to Tenant. The mixture of full-size and compact passenger vehicle spaces shall be reasonably balanced. The number of spaces
specified in Section 1.01(18) is located within a reasonable distance from the entrance or entrances to the Premises, but such parking is on an unassigned, first-come, first-served basis among Tenant and other occupants of the Project.
Provided, however, the foregoing conditions and restrictions shall be interpreted as governing the use of, and not to deprive Tenant of, its right to use the number of Parking Spaces specified in Section 1.01(18). 

ARTICLE THREE 
 RENT 

Tenant agrees to pay to Landlord at the first office specified in Section 1.01(2), or to such other persons, or at such other places designated by Landlord,
without any prior demand therefor in immediately available funds and without any deduction or offset whatsoever, Rent, including Monthly Base Rent and Rent Adjustments in accordance with Article Four, during the Term. Monthly Base Rent shall be paid
monthly in advance on the first day of each month of the Term, except that the first installment of Monthly Base Rent shall be paid by Tenant to Landlord simultaneously with Tenant’s execution and delivery of this Lease to Landlord. Monthly
Base Rent shall be prorated for partial months within the Term. Unpaid Rent shall bear interest at the Default Rate from the date due until paid. Tenant’s covenant to pay Rent shall be independent of every other covenant in this Lease.

 ARTICLE FOUR 
 OPERATING
EXPENSES, RENT ADJUSTMENTS AND PAYMENTS 
  

	4.01      	TENANT’S SHARE OF OPERATING EXPENSES 

 Tenant shall pay
Tenant’s Share of Operating Expenses in the respective shares of the respective categories of Operating Expenses as set forth below. 
 (a)       Tenant’s Project Share of Project Operating Expenses, which is the percentage obtained by dividing the rentable square footage of the Premises for the building(s) in
which the Premises is located by the rentable square footage of the Project and as of the date hereof equals the percentage set forth in Section 1.01(16); 
 (b)       Tenant’s Building Share of Building Operating Expenses, which is the percentage obtained by dividing the rentable square footage of the Premises respectively for each
building in which the Premises is located by the total rentable square footage of such building and as of the date hereof equals the percentage set forth in Section 1.01(16); 

(c)       Tenant’s Phase Share of Phase Operating Expenses, which is the percentage obtained by
dividing the aggregate rentable square footage of the Premises located in Tenant’s Phase by the total rentable square footage of Tenant’s Phase and as of the date hereof equals the percentage set forth in Section 1.01(16); 

(d)       Project Operating Expenses shall mean all Operating Expenses that are not included as Phase
Operating Expenses (defined below) and that are not either Building Operating Expenses or operating expenses directly and separately identifiable to the operation, maintenance or repair of any other building located in the Project, but Project
Operating Expenses includes operating expenses allocable to any areas of the Building or any other building during such time as such areas are made available by Landlord for the general common use or benefit of all tenants of the Project, and their
employees and invitees, or the public, as such areas currently exist and as they may be changed from time to time; 

(e)       Building Operating Expenses shall mean Operating Expenses that are directly and separately
identifiable to each building in which the Premises or part thereof is located; 
 (f)      
Phase Operating Expenses shall mean Operating Expenses that Landlord may allocate to a Phase as directly and separately identifiable to all buildings located in the Phase (including but not limited to the Building) and may include Project Operating
Expenses that are separately identifiable to a Phase; 
 (g)       Landlord shall have the
right to allocate a particular item or portion of Operating Expenses as any one of Project Operating Expenses, Building Operating Expenses or Phase Operating Expenses, but such allocations must be reasonable and in accordance with the definitions of
such expenses set forth above in Subsections 4.01(d), (e) and (f), and in no event shall any portion of Building Operating Expenses, Project Operating Expenses or Phase Operating Expenses be assessed or counted against Tenant more than once;
and. 

  
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(h)       Notwithstanding anything to the contrary contained in this Section 4.01, as to each
specific category of Operating Expense which one or more tenants of the Building either pays directly to third parties or specifically reimburses to Landlord (for example, separately contracted janitorial services or property taxes directly
reimbursed to Landlord), then, on a category by category basis, the amount of Operating Expenses for the affected period shall be adjusted as follows: (1) all such tenant payments with respect to such category of expense and all of
Landlord’s costs reimbursed thereby shall be excluded from Operating Expenses and Tenant’s Building Share, Tenant’s Phase Share or Tenant’s Project Share, as the case may be, for such category of Operating Expense shall be
adjusted by excluding the square footage of all such tenants, and (2) if Tenant pays or directly reimburses Landlord for such category of Operating Expense, such category of Operating Expense shall be excluded from the determination of
Operating Expenses for the purposes of this Lease. 
  

	4.02      	RENT ADJUSTMENTS 

 Tenant shall pay to Landlord Rent Adjustments
with respect to each Adjustment Year as follows: 
 (a)       The Rent Adjustment Deposit
shall be paid monthly during the Term with the payment of Monthly Base Rent, except the first installment which shall be paid by Tenant to Landlord concurrently with execution of this Lease. The Rent Adjustment Deposit represents, on a monthly
basis, Tenant’s Share of Landlord’s estimate of Operating Expenses, as described in Section 4.01, for the applicable Adjustment Year (or portion thereof); and 

(b)       Any Rent Adjustments due in excess of the Rent Adjustment Deposits in accordance with
Section 4.03. 
  

	4.03      	STATEMENT OF LANDLORD 

 Within one hundred twenty (120) days
after the end of each calendar year or as soon thereafter as reasonably possible, Landlord will furnish Tenant a statement (“Landlord’s Statement”) showing the following: 

(a)       Operating Expenses for the last Adjustment Year showing in reasonable detail the actual
Operating Expenses categorized among Project Operating Expenses, Building Operating Expenses and Phase Operating Expenses for such period and Tenant’s Share of each as described in Section 4.01 above; 

(b)       The amount of Rent Adjustments due Landlord for the last Adjustment Year, less credit for
Rent Adjustment Deposits paid, if any; and 
 (c)       Any change in the Rent Adjustment
Deposit due monthly in the current Adjustment Year, including the amount or revised amount due for months preceding any such change pursuant to Landlord’s Statement. 
 Tenant shall pay to Landlord within thirty (30) days after receipt of such statement any amounts for Rent Adjustments then due in accordance with Landlord’s Statement. Any amounts due from Landlord to
Tenant pursuant to this Section shall be credited to the Rent Adjustment Deposit next coming due, or refunded to Tenant if the Term has already expired provided Tenant is not in default hereunder. No interest or penalties shall accrue on any amounts
which Landlord is obligated to credit or refund to Tenant by reason of this Section 4.03. Landlord’s failure to deliver Landlord’s Statement or to compute the amount of the Rent Adjustments shall not constitute a waiver by Landlord of
its right to deliver such items nor constitute a waiver or release of Tenant’s obligations to pay such amounts. The Rent Adjustment Deposit shall be credited against Rent Adjustments due for the applicable Adjustment Year. During the last
complete calendar year or during any partial calendar year in which the Lease terminates, Landlord may include in the Rent Adjustment Deposit its estimate of Rent Adjustments which may not be finally determined until after the termination of this
Lease. Tenant’s obligation to pay Rent Adjustments survives the expiration or termination of the Lease. 
  

	4.04      	BOOKS AND RECORDS 

 Landlord shall maintain books and records
showing Operating Expenses and Taxes in accordance with sound accounting and management practices, consistently applied. The Tenant or its representative (which representative shall be a certified public accountant licensed to do business in the
state in which the Property is located and whose primary business is certified public accounting) shall have the right, for a period of ninety (90) days following the date upon which Landlord’s Statement is delivered to Tenant, to examine
the Landlord’s books and records with respect to the items in the foregoing statement of Operating Expenses and Taxes during normal business hours, upon written notice, delivered at least three (3) business days in advance. If Tenant does
not object in writing to Landlord’s Statement within one hundred twenty (120) days of Tenant’s receipt thereof, specifying the nature of the item in dispute and the reasons therefor, then Landlord’s Statement shall be considered
final and accepted by Tenant. Any amount due to the Landlord as shown on Landlord’s Statement, whether or not disputed by Tenant as provided herein shall be paid by Tenant when due as provided above, without prejudice to any such written
exception. 

  
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	4.05      	TENANT OR LEASE SPECIFIC TAXES 

 In addition to Monthly Base Rent,
Rent Adjustments, Rent Adjustment Deposits and other charges to be paid by Tenant, Tenant shall pay to Landlord, upon demand, any and all taxes payable by Landlord (other than federal or state inheritance, general income, gift or estate taxes)
whether or not now customary or within the contemplation of the parties hereto: (a) upon, allocable to, or measured by the Rent payable hereunder, including any gross receipts tax or excise tax levied by any governmental or taxing body with
respect to the receipt of such rent; or (b) upon or with respect to the possession, leasing, operation, management, maintenance, alteration, repair, use or occupancy by Tenant of the Premises or any portion thereof; or (c) upon the
measured value of Tenant’s personal property or trade fixtures located in the Premises or in any storeroom or any other place in the Premises or the Property, or the areas used in connection with the operation of the Property, it being the
intention of Landlord and Tenant that, to the extent possible, Tenant shall cause such taxes on personal property or trade fixtures to be billed to and paid directly by Tenant; (d) resulting from Landlord Work, Tenant Work or Tenant Alterations
to the Premises, whether title thereto is in Landlord or Tenant; or (e) upon this transaction. Taxes paid by Tenant pursuant to this Section 4.05 shall not be included in any computation of Taxes as part of Operating Expenses. 

ARTICLE FIVE 
 SECURITY 

  (a)       Tenant, at Tenant’s sole cost and expense, shall provide Landlord, simultaneously with
Tenant’s execution and delivery of this Lease to Landlord, with the “Letter of Credit” (defined below) and Tenant shall pay Landlord in immediately available funds the cash amount of the Security specified in Section 1.01 as
security (“Security”) for the full and faithful performance by Tenant of each and every term, provision, covenant, and condition of this Lease. If Tenant fails timely to perform any of the terms, provisions, covenants and conditions of
this Lease or any other document executed by Tenant in connection with this Lease, including, but not limited to, the payment of Rent or the repair of damage to the Premises caused by Tenant (excluding normal wear and tear), beyond any applicable
notice and cure period, then Landlord may use, apply, or retain the whole or any part of the Security for the payment of any Rent not paid when due, for the cost of repairing such damage, for the cost of cleaning the Premises, for the payment of any
other sum which Landlord may expend or may be required to expend by reason of Tenant’s failure to perform, and otherwise for compensation of Landlord for any other loss or damage to Landlord occasioned by Tenant’s failure to perform,
including, but not limited to, any loss of future Rent and any damage or deficiency in the reletting of the Premises (whether such loss, damages or deficiency accrue before or after summary proceedings or other reentry by Landlord) and the amount of
the unpaid past Rent, future Rent loss, and all other losses, costs and damages, that Landlord would be entitled to recover if Landlord were to pursue recovery under Section 11.02(b) or (c) of this Lease or California Civil Code
Section 1951.2 or 1951.4 (and any supplements, amendments, replacements and substitutions thereof and therefor from time to time). If Landlord so uses, applies or retains all or part of the Security, Tenant shall within five (5) business
days after demand pay or deliver to Landlord in immediately available funds the sum necessary to replace the amount used, applied or retained. If Tenant has fully and faithfully performed and observed all of Tenant’s obligations under the
terms, provisions, covenants and conditions of this Lease, the Security (except any amount retained for application by Landlord as provided herein) shall be returned or paid over to Tenant no later than ninety (90) days after the latest of:
(i) the Termination Date; (ii) the removal of Tenant from the Premises; (iii) the surrender of the Premises by Tenant to Landlord in accordance with this Lease; or (iv) the date Rent Adjustments owed pursuant to this Lease have
been computed by Landlord and paid by Tenant. Provided, however, in no event shall any such return be construed as an admission by Landlord that Tenant has performed all of its obligations hereunder. 

  (b)       The Security, whether in the form of cash, Letter of Credit and/or Letter of Credit Proceeds
(defined below), shall not be deemed an advance rent deposit or an advance payment of any kind, or a measure of Landlord’s damages with respect to Tenant’s failure to perform, nor shall any action or inaction of Landlord with respect to it
or its use or application be a waiver of, or bar or defense to, enforcement of any right or remedy of Landlord. Landlord shall not be required to keep the Security separate from its general funds and shall not have any fiduciary duties or other
duties (except as set forth in this Section) concerning the Security. Tenant shall not be entitled to any interest on the Security. In the event of any sale, lease or transfer of Landlord’s interest in the Building, Landlord shall have the
right to transfer the Security, or balance thereof, to the vendee, transferee or lessee and any such transfer shall release Landlord from all liability for the return of the Security. Tenant thereafter shall look solely to such vendee, transferee or
lessee for the return or payment of the Security. Tenant shall not assign or encumber or attempt to assign or encumber the Security or any interest in it and Landlord shall not be bound by any such assignment, encumbrance, attempted assignment or
attempted encumbrance, and regardless of one or more assignments of this Lease, Landlord may return the Security to the original Tenant without liability to any assignee. Tenant hereby waives any and all rights of Tenant under the provisions of
Section 1950.7 of the California Civil Code, and any and all rights of Tenant under all provisions of law, now or hereafter enacted, regarding security deposits. 
   (c)       If Tenant fails timely to perform any obligation under this Article Five, such breach shall constitute a Default by Tenant under this Lease without any right to
or requirement of any further notice or cure period under any other Article of this Lease, except such notice and cure period expressly provided under this Article Five. 
   (d)       As used herein, “Letter of Credit” shall mean an unconditional, irrevocable sight draft letter of credit issued, presentable and payable at the San
Francisco, San Francisco Peninsula or San Jose office of a major national bank satisfactory to Landlord in its sole discretion (the “Bank”), naming Landlord as beneficiary, in an amount equal to One Hundred Fifty Thousand and 00/100
Dollars ($150,000.00). The Letter of Credit shall provide: (i) that Landlord may make partial and multiple draws thereunder, up to the face amount thereof, and that Landlord may draw upon the Letter of Credit up to the full amount thereof, as
determined by Landlord, and the Bank will pay to Landlord the amount of such draw upon receipt by the Bank of a sight draft signed by Landlord without requirement for any additional documents or statements by Landlord; and (ii) that, in the
event of assignment or other transfer of either Landlord’s interest in this Lease or of any interest in Landlord (including, without limitation, consolidations, mergers, reorganizations or other entity changes), the Letter of Credit shall be
freely transferable by Landlord, without charge and without recourse, to the assignee or transferee of such interest and the Bank shall confirm the same to Landlord and such assignee or transferee. The Letter of Credit shall be in the form attached
as Exhibit E hereto. Landlord may (but shall not be required to) draw upon the Letter of Credit and use the proceeds therefrom (the “Letter of Credit Proceeds”) or any portion thereof in any manner Landlord is permitted to use the
Security under this Article Five. In the event Landlord draws upon the Letter of Credit and elects not to terminate the Lease, but to use the Letter of Credit Proceeds, then within ten (10) business days after Landlord gives Tenant written
notice specifying the amount of the Letter of Credit Proceeds so utilized by Landlord, Tenant shall immediately deliver to Landlord an amendment to the Letter of Credit or a replacement Letter of Credit in an amount equal to one hundred percent
(100%) of the then-required amount of the Letter of Credit. Tenant’s failure to deliver such amendment or replacement of the Letter of Credit to Landlord within ten (10) business days after Landlord’s notice shall constitute a
Default by Tenant under this Lease. The Letter of Credit shall have an initial term of no longer than one (1) year, shall be “evergreen”, and shall be extended, reissued or replaced by Tenant, in each case at least thirty
(30) days prior to its expiration in a manner that fully complies with the requirements of this Article Five, so that in all events the Letter of Credit required hereunder shall be in full force and effect continuously until the date (the
“L/C Expiration Date”) for return of the Security described in Subsection (a) above. No more often than once per year, Landlord shall have the right to require Tenant to deliver to Landlord, on 15 days prior notice, a replacement
Letter of Credit on the same terms and conditions set forth in this Article Five, in the event that Landlord determines, in its good faith judgment, that the issuing Bank is no longer satisfactory to remain as the issuer of the Letter of Credit. Any
advice from the issuer that it intends to withdraw or not extend the Letter of Credit prior to any scheduled annual expiration or the L/C Expiration Date shall entitle the Landlord to immediately draw upon the Letter of Credit. 

  
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 ARTICLE SIX 

UTILITIES & SERVICES 
  

	6.01      	LANDLORD’S GENERAL SERVICES 

 Landlord shall provide
maintenance and services as provided in Article Eight. 
  

	6.02      	TENANT TO OBTAIN & PAY DIRECTLY 

  (a)       Tenant shall be responsible for and shall pay promptly all charges for gas, electricity, sewer,
heat, light, power, telephone, refuse pickup (to be performed on a regularly scheduled basis so that accumulated refuse does not exceed the capacity of Tenant’s refuse bins), janitorial service and all other utilities, materials and services
furnished directly to or used by Tenant in, on or about the Premises, together with all taxes thereon. Tenant shall contract directly with the providing companies for such utilities and services. 

  (b)       Notwithstanding any provision of the Lease to the contrary, without, in each instance, the
prior written consent of Landlord, as more particularly provided in Article Nine, Tenant shall not: (i) make any alterations or additions to the electric or gas equipment or systems or other Building systems. Tenant’s use of electric
current shall at no time exceed the capacity of the wiring, feeders and risers providing electric current to the Premises or the Building. The consent of Landlord to the installation of electric equipment shall not relieve Tenant from the obligation
to limit usage of electricity to no more than such capacity. 
  

	6.03      	TELEPHONE SERVICES 

 All telegraph, telephone, and communication
connections which Tenant may desire outside the Premises shall be subject to Landlord’s prior written approval, in Landlord’s sole discretion, and the location of all wires and the work in connection therewith shall be performed by
contractors approved by Landlord and shall be subject to the direction of Landlord, except that such approval is not required as to Tenant’s cabling from the Premises in a route designated by Landlord to any telephone cabinet or panel provided
for Tenant’s connection to the telephone cable serving the Building, so long as Tenant’s equipment does not require connections different than or additional to those to the telephone cabinet or panel provided. As to any such connections or
work outside the Premises requiring Landlord’s approval, Landlord reserves the right to designate and control the entity or entities providing telephone or other communication cable installation, removal, repair and maintenance outside the
Premises and to restrict and control access to telephone cabinets or panels. In the event Landlord designates a particular vendor or vendors to provide such cable installation, removal, repair and maintenance for the Building, Tenant agrees to abide
by and participate in such program. Tenant shall be responsible for and shall pay all costs incurred in connection with the installation of telephone cables and communication wiring in the Premises, including any hook-up, access and maintenance fees
related to the installation of such wires and cables in the Premises and the commencement of service therein, and the maintenance thereafter of such wire and cables; and there shall be included in Operating Expenses for the Building all
installation, removal, hook-up or maintenance costs incurred by Landlord in connection with telephone cables and communication wiring serving the Building which are not allocable to any individual users of such service but are allocable to the
Building generally. If Tenant fails to maintain all telephone cables and communication wiring in the Premises and such failure affects or interferes with the operation or maintenance of any other telephone cables or communication wiring serving the
Building, Landlord or any vendor hired by Landlord may enter into and upon the Premises forthwith and perform such repairs, restorations or alterations as Landlord deems necessary in order to eliminate any such interference (and Landlord may recover
from Tenant all of Landlord’s costs in connection therewith). No later than the Termination Date, Tenant agrees to remove all telephone cables and communication wiring installed by Tenant for and during Tenant’s occupancy, which Landlord
shall request Tenant to remove. Tenant agrees that neither Landlord nor any of its agents or employees shall be liable to Tenant, or any of Tenant’s employees, agents, customers or invitees or anyone claiming through, by or under Tenant, for
any damages, injuries, losses, expenses, claims or causes of action because of any interruption, diminution, delay or discontinuance at any time for any reason in the furnishing of any telephone or other communication service to the Premises and the
Building, except that Landlord shall be responsible for repair or replacement of damage or destruction to Tenant’s telephone equipment and wiring to the extent caused by the gross negligence or willful and wrongful act of Landlord or its
employees or agents, but subject to the waivers set forth in Section 16.04. 

  
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	6.04      	FAILURE OR INTERRUPTION OF UTILITY OR SERVICE 

 To the extent that
any equipment or machinery furnished or maintained by Landlord outside the Premises is used in the delivery of utilities directly obtained by Tenant pursuant to Section 6.02 and breaks down or ceases to function properly, Landlord shall use
reasonable diligence to repair same promptly. In the event of any failure, stoppage or interruption of, or change in, any utilities or services supplied by Landlord which are not directly obtained by Tenant, Landlord shall use reasonable diligence
to have service promptly resumed. In either event covered by the preceding two sentences, if the cause of any such failure, stoppage or interruption of, or change in, utilities or services is within the control of a public utility, other public or
quasi-public entity, or utility provider outside Landlord’s control, notification to such utility or entity of such failure, stoppage or interruption and request to remedy the same shall constitute “reasonable diligence” by Landlord
to have service promptly resumed. In the event of any failure, stoppage or interruption of, or change in, any utility or other service furnished to the Premises or the Project resulting from any cause, including changes in service provider or
Landlord’s compliance with any voluntary or similar governmental or business guidelines now or hereafter published or any requirements now or hereafter established by any governmental agency, board or bureau having jurisdiction over the
operation of the Property: (a) Landlord shall not be liable for, and Tenant shall not be entitled to, any abatement or reduction of Rent; (b) no such failure, stoppage, or interruption of any such utility or service shall constitute an
eviction of Tenant or relieve Tenant of the obligation to perform any covenant or agreement of this Lease to be performed by Tenant; (c) Landlord shall not be in breach of this Lease nor be liable to Tenant for damages or otherwise.
Notwithstanding any other provision of this Section to the contrary, in the event and to the extent that the Premises is rendered untenantable and Tenant is unable to occupy the Premises or some portion thereof for five (5) consecutive business
days after Tenant has given Landlord written notice of such condition (the “Eligibility Period”) as a result of Landlord’s negligent failure, or willful and wrongful failure, to provide or perform utilities, services or repairs which
Landlord is obligated to provide or perform under this Lease, but excluding any period occupancy is prevented to the extent caused by any of the following: (i) any negligence or willful misconduct of Tenant, any assignee, any subtenant or any
other occupant of the Premises, or of any employee, agent or invitee of any of them; (ii) request by Tenant or any assignee that Landlord make a repair, decoration, alteration, improvement or addition; or (iii) Force Majeure, then Monthly
Base Rent and Rent Adjustments shall be abated for the period Tenant is so prevented from occupying the Premises, or on a pro-rated basis if Tenant is so prevented from occupying only part of Premises, commencing as of the first day after the
Eligibility Period and continuing for such time that Tenant is prevented from occupying the Premises or such part. 
  

	6.05      	CHOICE OF SERVICE PROVIDER 

 Tenant acknowledges that Landlord may,
at Landlord’s sole option, to the extent permitted by applicable law, elect to change, from time to time, the company or companies which provide services (including electrical service, gas service, water, telephone and technical services) to
the Property, the Premises and/or its occupants. Notwithstanding anything to the contrary set forth in this Lease, Tenant acknowledges that Landlord has not and does not make any representations or warranties concerning the identity or identities of
the company or companies which provide services to the Property and the Premises or its occupants and Tenant acknowledges that the choice of service providers and matters concerning the engagement and termination thereof shall be solely that of
Landlord. The foregoing provision is not intended to modify, amend, change or otherwise derogate from any provision of this Lease concerning the nature or type of service to be provided or any specific information concerning the amount thereof to be
provided. Tenant agrees to cooperate with Landlord and each of its service providers in connection with any change in service or provider. 
  

	6.06      	SIGNAGE 

 Tenant shall not install any signage within the Project,
the Building or the Premises without obtaining the prior written approval of Landlord, and Tenant shall be responsible for procurement, installation, maintenance and removal of any such signage installed by Tenant, and all costs in connection
therewith. Any such signage shall comply with Landlord’s current Project signage criteria and all Laws. 
 ARTICLE SEVEN 

POSSESSION, USE AND CONDITION OF PREMISES 
  

	7.01      	POSSESSION AND USE OF PREMISES 

              (a)       Tenant shall occupy and use the
Premises only for the uses specified in Section 1.01(17) to conduct Tenant’s business. Tenant shall not occupy or use the Premises (or permit the use or occupancy of the Premises) for any purpose or in any manner which: (1) is
unlawful or in violation of any Law or Environmental Law; (2) may be dangerous to persons or property or which may invalidate, any policy of insurance carried on the Building or Project or covering its operations or which may increase the cost
of any such insurance or insurance carried by any other occupant of the Project unless such increase is paid by Tenant; (3) is contrary to or prohibited by the terms and conditions of this Lease or the rules and regulations as provided in
Article Eighteen; (4) contrary to or prohibited by the articles, bylaws or rules of any owner’s association affecting the Project; (5) is improper, immoral, or objectionable; (6) would obstruct or interfere with the rights of
other tenants or occupants of the Building or the Project, or injure or annoy them, or would tend to create or continue a nuisance; or (7) would constitute any waste in or upon the Premises or Project. 

  
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 (b)       Landlord
and Tenant acknowledge that the Americans With Disabilities Act of 1990 (42 U.S.C. §12101 et seq.) and regulations and guidelines promulgated thereunder, as all of the same may be amended and supplemented from time to time (collectively
referred to herein as the “ADA”) establish requirements for business operations, accessibility and barrier removal, and that such requirements may or may not apply to the Premises, the Building and the Project depending on, among other
things: (1) whether Tenant’s business is deemed a “public accommodation” or “commercial facility”, (2) whether such requirements are “readily achievable”, and (3) whether a given alteration affects a
“primary function area” or triggers “path of travel” requirements. The parties hereby agree that: (a) Landlord shall be responsible for ADA Title III compliance in the Common Areas, except as provided below, (b) Tenant
shall be responsible for ADA Title III compliance in the Premises, including any leasehold improvements or other work to be performed in the Premises under or in connection with this Lease, (c) Landlord may perform, or require that Tenant
perform, and Tenant shall be responsible for the cost of, ADA Title III “path of travel” requirements triggered by Tenant Additions in the Premises, and (d) Landlord may perform, or require Tenant to perform, and Tenant shall be
responsible for the cost of, ADA Title III compliance in the Common Areas necessitated by the Building being deemed to be a “public accommodation” instead of a “commercial facility” as a result of Tenant’s use of the
Premises. To the extent Tenant shall occupy the entire Building or an entire floor in the Building, all ADA Title III requirements relating to the restrooms, elevator lobbies and corridors on such floor shall be the responsibility of Tenant. In such
event, all matters related to “life safety” on such floor shall also be the responsibility of Tenant. Tenant shall be solely responsible for requirements under Title I of the ADA relating to Tenant’s employees. 

  (c)       Landlord and Tenant agree to cooperate and use commercially reasonable efforts to participate
in traffic management programs generally applicable to businesses located in or about the area and Tenant shall encourage and support van and car pooling by, and staggered and flexible working hours for, its office workers and service employees to
the extent reasonably permitted by the requirements of Tenant’s business. Neither this Section or any other provision of this Lease is intended to or shall create any rights or benefits in any other person, firm, company, governmental entity or
the public. 
   (d)       Tenant agrees to cooperate with Landlord and to comply with any and all
guidelines or controls concerning energy management imposed upon Landlord by federal or state governmental organizations or by any energy conservation association to which Landlord is a party or which is applicable to the Building. 

 

	7.02      	HAZARDOUS MATERIAL 

              (a)       Tenant shall not use, generate,
manufacture, produce, store, handle, release, discharge, or dispose of, on, under or about the Premises or any part of the Project, or transport to or from the Premises or any part of the Project, any Hazardous Material or allow any “Tenant
Parties” (defined below) to do so, except as expressly permitted below, without the prior written consent of Landlord, which may be withheld in Landlord’s sole discretion. For purposes of this Lease, “Tenant Parties” shall mean
all occupants or users of the Premises permitted or suffered by Tenant, or the employees, servants, agents, contractors, customers or invitees of Tenant or of any such occupants or users. Provided that the Premises are used only for the uses
specified in Section 1.01 and Section 7.01 above, the foregoing prohibition shall not prohibit Tenant from using and storing in, and transporting to and from, the Premises, the types and amounts of Hazardous Material as specified on
Exhibit D hereto and by this reference incorporated herein (“Permitted Hazardous Material”) and insignificant amounts of Hazardous Material typically used in general business office applications (to the extent the Premises is used
for general offices) so long as (i) such substances are used in accordance with the manufacturers’ instructions therefor and all applicable Laws, (ii) such substances are not used or disposed of in or about the Building or the Project
in a manner which would constitute a release or discharge thereof, and (iii) all Hazardous Material is removed from the Building and the Project by Tenant no later than the Termination Date. If Tenant desires to add additional types or
quantities of Hazardous Materials to the list of Permitted Hazardous Materials specified in Exhibit D, Tenant shall give Landlord notice of the Hazardous Materials and quantities thereof that Tenant desires to use at the Premises and Landlord
shall thereafter have the right to approve or disapprove such additional Hazardous Materials in Landlord’s sole discretion within twenty (20) days after receipt of such notice. Failure to notify Tenant in writing of its decision within
said twenty (20) day period shall be deemed disapproval by Landlord. Whether or not Landlord approves any such request for changes, Tenant shall pay Landlord, within ten (10) days after request by Landlord, the actual fees and expenses of
any consultants retained by Landlord in connection with review of the proposed changes in Permitted Hazardous Material. Tenant shall, within fifteen (15) days after demand therefor, deliver to Landlord a written list identifying any Hazardous
Material then maintained by Tenant in the Building, the use of each such Hazardous Material so maintained by Tenant together with written certification by Tenant stating, in substance, that neither Tenant nor any Tenant Parties has released or
discharged any Hazardous Material in or about the Building or the Project. Tenant shall, within fifteen (15) days after demand therefor, deliver to Landlord a copy of: (x) all permits, licenses and other governmental and regulatory
approvals with respect to the use, generation, manufacture, production, storage, handling, release, discharge, removal and disposal by Tenant or Any of the Tenant Parties of Hazardous Material at the Project; and (y) each hazardous material
management plan or similar document (“Plan(s)”) with respect to use, generation, manufacture, production, storage, handling, release, discharge, removal or disposal of Hazardous Material by Tenant or any of the Tenant Parties necessary to
comply with Environmental Laws or other Laws prepared by or on behalf of Tenant or any of the Tenant Parties (whether or not required to be submitted to a governmental agency). Tenant shall comply with all Environmental Laws pertaining to
Tenant’s occupancy and use of the Premises and concerning the proper storage, handling and disposal of any Hazardous Material introduced to the Premises, the Building or the Property by Tenant or any Tenant Parties. Landlord shall comply with
all Environmental Laws applicable to the Property other than those to be complied with by Tenant pursuant to the preceding sentence. In the event that Tenant is notified of any investigation or violation of any Environmental Law arising from
Tenant’s activities at the Premises, Tenant shall immediately deliver to Landlord a copy of such notice. In such event or in the event Landlord reasonably believes that a violation of Environmental Law exists, Landlord may conduct such tests
and studies relating to compliance by Tenant with Environmental Laws or the alleged presence of Hazardous Material upon the Premises as Landlord deems desirable, all of which shall be completed at Tenant’s expense. To the extent permitted by
Law, Tenant hereby indemnifies, and agrees to protect, defend and hold the Indemnitees harmless, against any and all actions, claims, demands, liability, costs and expenses, including attorneys’ fees and expenses for the defense thereof,
arising out of any and all of (i) the introduction, use, discharge or release of any Hazardous Material into, in or about the Project by Tenant or any Tenant Parties, including any injury to or death of persons or damage to or destruction of
property resulting therefrom, and (ii) any failure of Tenant or any Tenant Parties to observe the covenants of this Section 7.02. In case of any action or proceeding brought against the Indemnitees by reason of any such claim, upon notice
from Landlord, Tenant covenants to defend such action or proceeding by counsel chosen by Landlord, in Landlord’s sole discretion. Landlord reserves the right to settle, compromise or dispose of any and all actions, claims and demands related to
the foregoing indemnity. If any Hazardous Material is released, discharged or disposed of on or about the Property and such release, discharge or disposal is not caused by Tenant or any Tenant Parties, such release, discharge or disposal shall be
deemed casualty damage under Article Fourteen to the extent that the Premises are affected thereby; in such case, Landlord and Tenant shall have the obligations and rights respecting such casualty damage provided under such Article. 

  
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  (b)       The right to use and store in, and transport to and from, the Premises the Permitted Hazardous
Material is personal to AcelRx Pharmaceuticals, Inc., a Delaware corporation, and may not be assigned or otherwise transferred by AcelRx Pharmaceuticals, Inc., a Delaware corporation, without the prior written consent of Landlord, which consent may
be withheld in Landlord’s sole discretion, except (i) to a Permitted Transferee which is an assignee of the Lease and which has satisfied the requirements of Sections 10.01 and 10.05 of this Lease; and (ii) AcelRx may permit a
Permitted Transferee which is a sublessee to use and store in, and transport to and from, the Premises the Permitted Hazardous Material to the same extent as AcelRx has such right under this Lease, subject to all the provisions of this Lease. . Any
consent by Landlord pursuant to Article Ten to an assignment, transfer, subletting, mortgage, pledge, hypothecation or encumbrance of this Lease, and any interest therein or right or privilege appurtenant thereto, shall not constitute consent by
Landlord to the use or storage at, or transportation to, the Premises of any Hazardous Material (including a Permitted Hazardous Material) by any such assignee, sublessee or transferee unless Landlord expressly agrees otherwise in writing. Provided
however, at the time Tenant requests approval of any proposed assignment or sublease of this Lease by Tenant, and the assignee or sublessee desires to use Hazardous Materials, Tenant shall submit to Landlord the proposed Permitted Hazardous Material
list of the proposed assignee or sublessee. Landlord shall have the right, in its sole discretion, to approve the proposed assignee’s or sublessee’s proposed Permitted Hazardous Material list, or to require modifications to said list. In
the event that Landlord does not approve of the proposed assignee’s or sublessee’s Permitted Hazardous Material list, or the proposed assignee or sublessee cannot or will not modify said list, then it shall be reasonable for purposes of
Article Ten hereof for Landlord to refuse its consent to the proposed assignment or sublease. In the event that the proposed Hazardous Material list of the assignee or sublessee includes any Hazardous Material different from or in greater quantity
than Tenant’s Permitted Hazardous Material, Tenant shall pay Landlord, whether or not Landlord consents to the proposed list of Permitted Hazardous Material and/or to the proposed assignment or sublease, (i) a processing fee of Three
Thousand Dollars ($3,000.00) at the time Tenant submits the request for approval, and (ii) within ten (10) days after request by Landlord, the actual fees and expenses of any consultants retained by Landlord in connection with review of
the proposed Permitted Hazardous Material list and use thereof by the proposed assignee or sublessee. Any consent by Landlord to the use or storage at, or transportation to or from the Premises, of any Hazardous Material (including a Permitted
Hazardous Material) by an assignee, sublessee or transferee of Tenant shall not constitute a waiver of Landlord’s right to refuse such consent as to any subsequent assignee or transferee. 

  (c)       Tenant acknowledges that the sewer piping at the Project is made of ABS plastic. Accordingly,
without Landlord’s prior written consent, which may be given or withheld in Landlord’s reasonable discretion, only ordinary domestic sewage is permitted to be put into the drains at the Premises. UNDER NO CIRCUMSTANCES SHALL Tenant EVER
DEPOSIT ANY ESTERS OR KETONES (USUALLY FOUND IN SOLVENTS TO CLEAN UP PETROLEUM PRODUCTS) IN THE DRAINS AT THE PREMISES. If Tenant desires to put any substances other than ordinary domestic sewage into the drains, it shall first submit to Landlord a
complete description of each such substance, including its chemical composition, and a sample of such substance suitable for laboratory testing. Landlord shall promptly determine whether or not the substance can be deposited into the drains and its
determination shall be absolutely binding on Tenant. Upon demand, Tenant shall reimburse Landlord for expenses incurred by Landlord in making such determination. If any substances not so approved hereunder are deposited in the drains in
Tenant’s Premises, Tenant shall be liable to Landlord for all damages resulting therefrom, including but not limited to all costs and expenses incurred by Landlord in repairing or replacing the piping so damaged. 

 

	7.03      	LANDLORD ACCESS TO PREMISES; APPROVALS 

  (a)       Tenant shall permit Landlord to erect, use and maintain pipes, ducts, wiring and conduits in
and through the Premises, so long as Tenant’s use, layout or design of the Premises is not materially affected or altered. Landlord or Landlord’s agents shall have the right to enter upon the Premises in the event of an emergency, or to
inspect the Premises, to perform janitorial and other services (if any), to conduct safety and other testing in the Premises and to make such repairs, alterations, improvements or additions to the Premises or the Building or other parts of the
Property as Landlord may deem necessary or desirable (including all alterations, improvements and additions in connection with a change in service provider or providers). Janitorial and cleaning services (if any) shall be performed after normal
business hours. Any entry or work by Landlord may be during normal business hours and Landlord may use reasonable efforts to ensure that any entry or work shall not materially interfere with Tenant’s occupancy of the Premises. 

  (b)       If Tenant shall not be personally present to permit an entry into the Premises when for any
reason an entry therein shall be necessary or permissible, Landlord (or Landlord’s agents), after attempting to notify Tenant (unless Landlord believes an emergency situation exists), may enter the Premises without rendering Landlord or its
agents liable therefor, and without relieving Tenant of any obligations under this Lease. 

  
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  (c)       Landlord may enter the Premises for the purpose of conducting such inspections, tests and
studies as Landlord may deem desirable or necessary to confirm Tenant’s compliance with all Laws and Environmental Laws or for other purposes necessary in Landlord’s reasonable judgment to ensure the sound condition of the Property and the
systems serving the Property. Landlord’s rights under this Section 7.03 (c) are for Landlord’s own protection only, and Landlord has not, and shall not be deemed to have assumed, any responsibility to Tenant or any other party as
a result of the exercise or non-exercise of such rights, for compliance with Laws or Environmental Laws or for the accuracy or sufficiency of any item or the quality or suitability of any item for its intended use. 

  (d)       Landlord may do any of the foregoing, or undertake any of the inspection or work described in
the preceding paragraphs without such action constituting an actual or constructive eviction of Tenant, in whole or in part, or giving rise to an abatement of Rent by reason of loss or interruption of business of the Tenant, or otherwise.

   (e)       The review, approval or consent of Landlord with respect to any item required or
permitted under this Lease is for Landlord’s own protection only, and Landlord has not, and shall not be deemed to have assumed, any responsibility to Tenant or any other party, as a result of the exercise or non-exercise of such rights, for
compliance with Laws or Environmental Laws or for the accuracy or sufficiency of any item or the quality or suitability of any item for its intended use. 
  

	7.04      	QUIET ENJOYMENT 

 Landlord covenants, in lieu of any implied
covenant of quiet possession or quiet enjoyment, that so long as Tenant is not in Default in compliance with the covenants and conditions set forth in this Lease, Tenant shall have the right to quiet enjoyment of the Premises without hindrance or
interference from Landlord or those claiming through Landlord, and subject to the covenants and conditions set forth in the Lease and to the rights of any Mortgagee or ground lessor. 

ARTICLE EIGHT 
 MAINTENANCE

  

	8.01      	LANDLORD’S MAINTENANCE 

 Subject to Article Fourteen and
Section 8.02, Landlord shall maintain, in a manner compatible with maintenance of comparable properties in the immediate vicinity of the Project, the structural portions of the Building, the roof, exterior walls and exterior doors, foundation,
and underslab standard sewer system of the Building in good, clean and safe condition, and shall use reasonable efforts, through Landlord’s program of regularly scheduled preventive maintenance, to keep the Building’s standard heating,
ventilation and air conditioning (“HVAC”) equipment in reasonably good order and condition. Notwithstanding the foregoing, Landlord shall have no responsibility to repair the Building’s standard heating, ventilation and air
conditioning equipment, and all such repairs shall be performed by Tenant pursuant to the terms of Section 8.02. Landlord shall also (a) maintain the landscaping, parking facilities and other Common Areas of the Project, and (b) wash
the outside of exterior windows at intervals determined by Landlord. Except as provided in Section 6.04, Article Fourteen and Article Fifteen, there shall be no abatement of rent, no allowance to Tenant for diminution of rental value and no
liability of Landlord by reason of inconvenience, annoyance or any injury to or interference with Tenant’s business arising from the making of or the failure to make any repairs, alterations or improvements in or to any portion of the Project
or in or to any fixtures, appurtenances or equipment therein. Tenant waives the right to make repairs at Landlord’s expense under any law, statute or ordinance now or hereafter in effect. 

 

	8.02      	TENANT’S MAINTENANCE 

 Subject to the provisions of Article
Fourteen, Tenant shall, at Tenant’s sole cost and expense, make all repairs to the Premises and fixtures therein which Landlord is not required to make pursuant to Section 8.01, including repairs to the interior walls, ceilings and windows
of the Premises, the interior doors, Tenant’s signage, and the electrical, life-safety, plumbing and heating, ventilation and air conditioning systems located within or serving the Premises and shall maintain the Premises, the fixtures and
utilities systems therein, and the area immediately surrounding the Premises (including all garbage enclosures), in a good, clean and safe condition. Tenant shall deliver to Landlord a copy of any maintenance contract entered into by Tenant with
respect to the Premises. Tenant shall also, at Tenant’s expense, keep any non-standard heating, ventilating and air conditioning equipment and other non-standard equipment in the Building in good condition and repair, using contractors approved
in advance, in writing, by Landlord. Notwithstanding Section 8.01 above, but subject to the waivers set forth in Section 16.04, Tenant will pay for any repairs to the Building or the Project which are caused by any negligence or
carelessness, or by any willful and wrongful act, of Tenant or its assignees, subtenants or employees, or of the respective agents of any of the foregoing persons, or of any other persons permitted in the Building or elsewhere in the Project by
Tenant or any of them. Tenant will maintain the Premises, and will leave the Premises upon termination of this Lease, in a safe, clean, neat and sanitary condition. 
 ARTICLE NINE 
 ALTERATIONS AND IMPROVEMENTS 

 

	9.01      	TENANT ALTERATIONS 

  (a)       The following provisions shall apply to the completion of any Tenant Alterations: 

        (1)       Tenant shall not, except as provided
herein, without the prior written consent of Landlord, which consent shall not be unreasonably withheld, make or cause to be made any Tenant Alterations in or to the Premises or any Property systems serving the Premises. Prior to making any Tenant
Alterations, Tenant shall give Landlord ten (10) days prior written notice (or such earlier notice as would be necessary pursuant to applicable Law) to permit Landlord sufficient time to post appropriate notices of non-responsibility. Subject
to all other requirements of this Article Nine, Tenant may undertake Decoration work without Landlord’s prior written consent. Tenant shall furnish Landlord with the names and addresses of all contractors and subcontractors and copies of all
contracts. All Tenant Alterations shall be completed at such time and in such manner as Landlord may from time to time designate, and only by contractors or mechanics approved by Landlord, which approval shall not be unreasonably withheld, provided,
however, that Landlord may, in its sole discretion, specify the engineers and contractors to perform all work relating to the Building’s systems (including the mechanical, heating, plumbing, security, ventilating, air-conditioning, electrical,
communication and the fire and life safety systems in the Building). The contractors, mechanics and engineers who may be used are further limited to those whose work will not cause or threaten to cause disharmony or interference with Landlord or
other tenants in the Building and their respective agents and contractors performing work in or about the Building. Landlord may further condition its consent upon Tenant furnishing to Landlord and Landlord approving prior to the commencement of any
work or delivery of materials to the Premises related to the Tenant Alterations such of the following as specified by Landlord: architectural plans and specifications, opinions from Landlord’s engineers stating that the Tenant Alterations will
not in any way adversely affect the Building’s systems, necessary permits and licenses, certificates of insurance, and such other documents in such form reasonably requested by Landlord. Landlord may, in the exercise of reasonable judgment,
request that Tenant provide Landlord with appropriate evidence of Tenant’s ability to complete and pay for the completion of the Tenant Alterations such as a performance bond or letter of credit. Upon completion of the Tenant Alterations,
Tenant shall deliver to Landlord an as-built mylar and digitized (if available) set of plans and specifications for the Tenant Alterations. 

  
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(2)       Tenant shall pay the cost of all Tenant Alterations and the cost of decorating the Premises
and any work to the Property occasioned thereby. Except for the construction administration fee for the Tenant Work (which shall be as set forth in Section 8,10 of the Workletter), in connection with completion of any Tenant Alterations, Tenant
shall pay Landlord a construction fee and all elevator and hoisting charges at Landlord’s then standard rate. Upon completion of Tenant Alterations, Tenant shall furnish Landlord with contractors’ affidavits and full and final waivers of
lien and receipted bills covering all labor and materials expended and used in connection therewith and such other documentation reasonably requested by Landlord or Mortgagee. 

(3)       Tenant agrees to complete all Tenant Alterations (i) in accordance with all Laws,
Environmental Laws, all requirements of applicable insurance companies and in accordance with Landlord’s standard construction rules and regulations, and (ii) in a good and workmanlike manner with the use of good grades of materials.
Tenant shall notify Landlord immediately if Tenant receives any notice of violation of any Law in connection with completion of any Tenant Alterations and shall immediately take such steps as are necessary to remedy such violation. In no event shall
such supervision or right to supervise by Landlord nor shall any approvals given by Landlord under this Lease constitute any warranty by Landlord to Tenant of the adequacy of the design, workmanship or quality of such work or materials for
Tenant’s intended use or of compliance with the requirements of Section 9.01(a)(3)(i) and (ii) above or impose any liability upon Landlord in connection with the performance of such work. 

  (b)       All Tenant Additions to the Premises whether installed by Landlord or Tenant, shall without
compensation or credit to Tenant, become part of the Premises and the property of Landlord at the time of their installation and shall remain in the Premises, unless pursuant to Article Twelve, Tenant may remove them or is required to remove them at
Landlord’s request. 
  

	9.02      	LIENS 

 Tenant shall not permit any lien or claim for lien of any
mechanic, laborer or supplier or any other lien to be filed against the Building, the Land, the Premises, or any other part of the Property arising out of work performed, or alleged to have been performed by, or at the direction of, or on behalf of
Tenant. If any such lien or claim for lien is filed, Tenant shall within ten (10) days of receiving notice of such lien or claim (a) have such lien or claim for lien released of record or (b) deliver to Landlord a bond in form,
content, amount, and issued by surety, satisfactory to Landlord, indemnifying, protecting, defending and holding harmless the Indemnitees against all costs and liabilities resulting from such lien or claim for lien and the foreclosure or attempted
foreclosure thereof. If Tenant fails to take any of the above actions, Landlord, in addition to its rights and remedies under Article Eleven, without investigating the validity of such lien or claim for lien, may pay or discharge the same and Tenant
shall, as payment of additional Rent hereunder, reimburse Landlord upon demand for the amount so paid by Landlord, including Landlord’s expenses and attorneys’ fees. 
 ARTICLE TEN 
 ASSIGNMENT AND SUBLETTING 

 

	10.01      	ASSIGNMENT AND SUBLETTING 

  (a)       Without the prior written consent of Landlord, which may be withheld in Landlord’s sole
discretion, Tenant may not sublease, assign, mortgage, pledge, hypothecate or otherwise transfer or permit the transfer of this Lease or the encumbering of Tenant’s interest therein in whole or in part, by operation of Law or otherwise or
permit the use or occupancy of the Premises, or any part thereof, by anyone other than Tenant, provided, however, if Landlord chooses not to recapture the space proposed to be subleased or assigned as provided in Section 10.02, Landlord shall
not unreasonably withhold its consent to a subletting or assignment under this Section 10.01. Tenant agrees that the provisions governing sublease and assignment set forth in this Article Ten shall be deemed to be

  
 15 

 
reasonable. If Tenant desires to enter into any sublease of the Premises or assignment of this Lease, Tenant shall deliver written notice thereof to Landlord (“Tenant’s Notice”),
together with the identity of the proposed subtenant or assignee and the proposed principal terms thereof and financial and other information sufficient for Landlord to make an informed judgment with respect to such proposed subtenant or assignee at
least sixty (60) days prior to the commencement date of the term of the proposed sublease or assignment. If Tenant proposes to sublease less than all of the Rentable Area of the Premises, the space proposed to be sublet and the space retained
by Tenant must each be a marketable unit as reasonably determined by Landlord and otherwise in compliance with all Laws. Landlord shall notify Tenant in writing of its approval or disapproval of the proposed sublease or assignment or its decision to
exercise its rights under Section 10.02 within thirty (30) days after receipt of Tenant’s Notice (and all required information). In no event may Tenant sublease any portion of the Premises or assign the Lease to any other tenant of
the Project. Tenant shall submit for Landlord’s approval (which approval shall not be unreasonably withheld) any advertising which Tenant or its agents intend to use with respect to the space proposed to be sublet. 

  (b)       With respect to Landlord’s consent to an assignment or sublease, Landlord may take into
consideration any factors which Landlord may deem relevant, and the reasons for which Landlord’s denial shall be deemed to be reasonable shall include, without limitation, the following: 

  (i)       the business reputation or creditworthiness of any proposed subtenant or assignee is not
acceptable to Landlord; or 
   (ii)       in Landlord’s reasonable judgment the proposed
assignee or subtenant would diminish the value or reputation of the Building or Landlord; or 

  (iii)       any proposed assignee’s or subtenant’s use of the Premises would violate
Section 7.01 of the Lease or would violate the provisions of any other leases of tenants in the Project; 

  (iv)       the proposed assignee or subtenant is either a governmental agency, a school or similar
operation, or a medical related practice; or 
   (v)       the proposed subtenant or assignee is
a bona fide prospective tenant of Landlord in the Project as demonstrated by a written proposal dated within ninety (90) days prior to the date of Tenant’s request; or 

  (vi)       the proposed subtenant or assignee would materially increase the estimated pedestrian and
vehicular traffic to and from the Premises and the Building. 
 In no event shall Landlord be obligated to consider a consent to any proposed assignment
of the Lease which would assign less than the entire Premises. In the event Landlord wrongfully withholds its consent to any proposed sublease of the Premises or assignment of the Lease, Tenant’s sole and exclusive remedy therefor shall be to
seek specific performance of Landlord’s obligations to consent to such sublease or assignment. 

  (c)       Any sublease or assignment shall be expressly subject to the terms and conditions of this
Lease. Any subtenant or assignee shall execute such documents as Landlord may reasonably require to evidence such subtenant or assignee’s assumption of the obligations and liabilities of Tenant under this Lease. Tenant shall deliver to Landlord
a copy of all agreements executed by Tenant and the proposed subtenant and assignee with respect to the Premises. Landlord’s approval of a sublease, assignment, hypothecation, transfer or third party use or occupancy shall not constitute a
waiver of Tenant’s obligation to obtain Landlord’s consent to further assignments or subleases, hypothecations, transfers or third party use or occupancy. 
   (d)       For purposes of this Article Ten, an assignment shall be deemed to include a change in the majority control of Tenant, resulting from any transfer, sale or
assignment of shares of stock of Tenant occurring by operation of Law or otherwise, and includes any merger, acquisition, consolidation or reorganization. Notwithstanding any provision of this Section to the contrary, an assignment for purposes of
this Article does not include any transfer of control of the stock or membership interests of Tenant through: (i) any public offering of shares of stock in Tenant in accordance with applicable State and Federal law, rules, regulations and
orders if thereafter the stock shall be listed and publicly traded through the New York Stock Exchange or the NASDAQ national market; or (ii) public sale of such stock effected through such exchange or the NASDAQ national market. If Tenant is a
partnership, any change in the partners of Tenant shall be deemed to be an assignment; or (iii) bona-fide, new issuance of shares of stock or membership interests of Tenant in a private offering or private offerings for fair cash consideration
immediately paid to Tenant which increases Tenant’s equity and net worth. 
   (e)      
Tenant may assign this Lease to a successor to Tenant by purchase, merger, consolidation or non-bankruptcy reorganization (an “Ownership Change”) or assign this Lease or sublet all or a portion of the Premises to an Affiliate without the
consent of Landlord, provided that all of the following conditions are satisfied (a “Permitted Transfer”, and such permitted assignee or subtenant is a “Permitted Transferee”): (i) Tenant is not in Default; (ii) in the
event of an Ownership Change, Tenant’s successor shall own substantially all of the assets of Tenant and have a net worth which is at least equal to Tenant’s net worth as of the day prior to the proposed Ownership Change, or in the event
of a Transfer to an Affiliate, Tenant continues to have a net worth equal to or greater than Tenant’s net worth at the date of this Lease or the Affiliate has a net worth equal to Tenant’s net worth at the date of this Lease;
(iii) Tenant shall give Landlord written notice at least 15 business days prior to the effective date of the Permitted Transfer; and (iv) Tenant and Tenant’s successor shall sign an assumption of all obligations of the Tenant under
the Lease, and if requested by Landlord, a form of agreement setting forth representations as to the type of Ownership Change and as to the facts that satisfy each of conditions (i) – (iii) above. Tenant’s notice to Landlord
shall include information and documentation evidencing the Permitted Transfer and showing that each of the above conditions has been satisfied. 

  
 16 

  

  (f)       With respect to any sublease, including any to a Permitted Transferee, Tenant hereby irrevocably
assigns to Landlord, effective upon any such sublease, all rent and other payments due from subtenant under the sublease, provided however, that Tenant shall have a license to collect such rent and other payments until the occurrence of a default by
Tenant under any of the provisions of the Lease, and notice to Tenant of such default shall not be a prerequisite to Landlord’s right to collect subrent. At any time at Landlord’s option, Landlord shall have the right to give notice to the
subtenant of such assignment. Landlord shall credit Tenant with any rent received by Landlord under such assignment but the acceptance of any payment on account of rent from the subtenant as the result of any such default shall in no manner
whatsoever serve to release Tenant from any liability under the terms, covenants, conditions, provisions or agreement under the Lease. No such payment of rent or any other payment by the subtenant directly to Landlord and/or acceptance of such
payment(s) by Landlord, regardless of the circumstances or reasons therefor, shall in any manner whatsoever be deemed an attornment by the subtenant to Landlord in the absence of a specific written agreement signed by Landlord to such an effect. For
purposes of this Section, any use or occupancy by a Permitted Transferee (unless it is an assignee) without a formal sublease shall for the purposes of this Section be deemed to be a sublease at the same rental rate as provided in the Lease.

  

	10.02      	RECAPTURE 

 Landlord shall have the option to exclude from the
Premises covered by this Lease (“recapture”), the space proposed to be sublet or subject to the assignment, so long as (i) the proposed transfer is not to a Permitted Transferee in accordance with the provisions of
Section 10.01(e), and (ii) the proposed sublease is for the remainder of the Term of this Lease and Landlord recaptures the entire portion of the Premises subject to the proposed sublease. If Landlord elects to recapture, such recapture
shall be effective as of the commencement date of such sublease or assignment, and Tenant shall surrender possession of the recapture space on the day immediately before such effective date, such date being the Termination Date for such space.
Effective as of the date of recapture of any portion of the Premises pursuant to this section, the Monthly Base Rent, Rentable Area of the Premises and Tenant’s Share shall be adjusted accordingly. 

 

	10.03      	EXCESS RENT 

 Tenant shall pay Landlord on the first day of each
month during the term of the sublease or assignment, fifty percent (50%) of the amount by which the sum of all rent and other consideration (direct or indirect) due from the subtenant or assignee for such month exceeds: (i) that portion of
the Monthly Base Rent and Rent Adjustments due under this Lease for said month which is allocable to the space sublet or assigned; and (ii) the following costs and expenses for the subletting or assignment of such space: (1) brokerage
commissions and attorneys’ fees and expenses, (2) the actual costs paid in making any improvements or substitutions in the Premises required by any sublease or assignment; and (3) “free rent” periods, costs of any
inducements or concessions given to subtenant or assignee, moving costs, and other amounts in respect of such subtenant’s or assignee’s other leases or occupancy arrangements. All such costs and expenses shall be amortized over the term of
the sublease or assignment pursuant to sound accounting principles. 
  

	10.04      	TENANT LIABILITY 

 In the event of any sublease or assignment,
whether or not with Landlord’s consent, Tenant shall not be released or discharged from any liability, whether past, present or future, under this Lease, including any liability arising from the exercise of any renewal or expansion option, to
the extent such exercise is expressly permitted by Landlord. Tenant’s liability shall remain primary, and in the event of default by any subtenant, assignee or successor of Tenant in performance or observance of any of the covenants or
conditions of this Lease, Landlord may proceed directly against Tenant without the necessity of exhausting remedies against said subtenant, assignee or successor. After any assignment, Landlord may consent to subsequent assignments or subletting of
this Lease, or amendments or modifications of this Lease with assignees of Tenant, without notifying Tenant, or any successor of Tenant, and without obtaining its or their consent thereto, and such action shall not relieve Tenant or any successor of
Tenant of liability under this Lease. If Landlord grants consent to such sublease or assignment, Tenant shall pay all reasonable attorneys’ fees and expenses incurred by Landlord with respect to any assignment or sublease. In addition, if
Tenant has any options to extend the term of this Lease or to add other space to the Premises, such options shall not be available to any subtenant or assignee, directly or indirectly without Landlord’s express written consent, which may be
withheld in Landlord’s sole discretion. 
  

	10.05      	ASSUMPTION AND ATTORNMENT 

 If Tenant shall assign this Lease as
permitted herein, the assignee shall expressly assume all of the obligations of Tenant hereunder in a written instrument satisfactory to Landlord and furnished to Landlord not later than fifteen (15) days prior to the effective date of the
assignment. If Tenant shall sublease the Premises as permitted herein, Tenant shall, at Landlord’s option, within fifteen (15) days following any request by Landlord, obtain and furnish to Landlord the written agreement of such subtenant
to the effect that the subtenant will attorn to Landlord and will pay all subrent directly to Landlord. 
 ARTICLE ELEVEN 

DEFAULT AND REMEDIES 
  

	11.01      	EVENTS OF DEFAULT 

 The occurrence or existence of any one or more
of the following shall constitute a “Default” by Tenant under this Lease: 

  (i)       Tenant fails to pay any installment or other payment of Rent including Rent
Adjustment Deposits or Rent Adjustments within five (5) business days after the date when due; 

  
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  (ii)       Tenant fails to observe or perform any of the other covenants, conditions or
provisions of this Lease or the Workletter and, unless the failure to perform is a Default for which this Lease specifies that there is no cure or grace period or no additional period to cure beyond that set forth in such other provision of this
Lease, fails to cure such default within thirty (30) days after written notice thereof to Tenant, provided that, if Tenant has exercised reasonable diligence to cure such failure and such failure cannot reasonably be cured within such thirty
(30) day period, then such cure period shall be extended, but not in excess of an additional sixty (60) days plus such period during which such cure is prevented due to Force Majeure, so long as Tenant diligently and continuously
prosecutes the cure to completion; 
   (iii)       the interest of Tenant in this
Lease is levied upon under execution or other legal process, and such levy is not dismissed or withdrawn within thirty (30) days; 
   (iv)       a petition is filed by or against Tenant to declare Tenant bankrupt or seeking a plan of reorganization or arrangement under any Chapter of the Bankruptcy Act,
or any amendment, replacement or substitution therefor, or to delay payment of, reduce or modify Tenant’s debts, which in the case of an involuntary action is not dismissed or withdrawn within thirty (30) days; 

  (v)       Tenant is declared insolvent by Law or any assignment of Tenant’s property
is made for the benefit of creditors; 
   (vi)       a receiver is appointed for
Tenant or Tenant’s property, which appointment is not discharged within thirty (30) days; or 

  (vii)       upon the dissolution of Tenant. 

 

	11.02	  LANDLORD’S REMEDIES 

    (a)       A Default shall constitute a breach of the Lease for which Landlord shall have the
rights and remedies set forth in this Section 11.02 and all other rights and remedies set forth in this Lease or now or hereafter allowed by Law, whether legal or equitable, and all rights and remedies of Landlord shall be cumulative and none
shall exclude any other right or remedy. 
     (b)       With respect to a Default, at
any time Landlord may terminate Tenant’s right to possession by written notice to Tenant stating such election. Upon the termination of Tenant’s right to possession pursuant to this Section 11.02, Tenant’s right to possession
shall terminate and this Lease shall terminate, and Tenant shall remain liable as hereinafter provided. Upon such termination, Landlord shall have the right, subject to applicable Law, to re-enter the Premises and dispossess Tenant and the legal
representatives of Tenant and all other occupants of the Premises by unlawful detainer or other summary proceedings, or otherwise as permitted by Law, regain possession of the Premises and remove their property (including their personal property and
those trade fixtures or Tenant Additions which Tenant is required or permitted to remove under Article Twelve), but Landlord shall not be obligated to effect such removal, and such property may, at Landlord’s option, be stored elsewhere, sold
or otherwise dealt with as permitted by Law, at the risk of, expense of and for the account of Tenant, and the proceeds of any sale shall be applied pursuant to Law. Landlord shall in no event be responsible for the value, preservation or
safekeeping of any such property. Tenant hereby waives all claims for damages that may be caused by Landlord’s removing or storing Tenant’s personal property pursuant to this Section or Section 12.01, and Tenant hereby indemnifies,
and agrees to defend, protect and hold harmless, the Indemnitees from any and all loss, claims, demands, actions, expenses, liability and cost (including attorneys’ fees and expenses) arising out of or in any way related to such removal or
storage. Upon such written termination of Tenant’s right to possession and this Lease, Landlord shall have the right to recover damages for Tenant’s Default as provided herein or by Law, including the following damages provided by
California Civil Code Section 1951.2: 
     (1)       the worth at
the time of award of the unpaid Rent which had been earned at the time of termination; 

    (2)       the worth at the time of award of the amount by which the unpaid
Rent which would have been earned after termination until the time of award exceeds the amount of such Rent loss that Tenant proves could reasonably have been avoided; 

    (3)       the worth at the time of award of the amount by which the unpaid
Rent for the balance of the term of this Lease after the time of award exceeds the amount of such Rent loss that Tenant proves could be reasonably avoided; and 
             (4)       any other amount necessary to compensate Landlord for all the detriment proximately caused by
Tenant’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom. The word “rent” as used in this Section 11.02 shall have the same meaning as the defined
term Rent in this Lease. The “worth at the time of award” of the amount referred to in clauses (1) and (2) above is computed by allowing interest at the Default Rate. The worth at the time of award of the amount referred to in
clause (3) above is computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent (1%). For the purpose of determining unpaid Rent under clause (3) above, the
monthly Rent reserved in this Lease shall be deemed to be the sum of the Monthly Base Rent, and monthly Storage Space Rent, if any, 

  
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and the amounts last payable by Tenant as Rent Adjustments for the calendar year in which Landlord terminated this Lease as provided hereinabove. 

  (c)       Even if Tenant is in Default and/or has abandoned the Premises, this Lease shall continue in
effect for so long as Landlord does not terminate Tenant’s right to possession by written notice as provided in Section 11.02(b) above, and Landlord may enforce all its rights and remedies under this Lease, including the right to recover
Rent as it becomes due under this Lease. In such event, Landlord shall have all of the rights and remedies of a landlord under California Civil Code Section 1951.4 (lessor may continue Lease in effect after Tenant’s Default and abandonment
and recover Rent as it becomes due, if Tenant has the right to sublet or assign, subject only to reasonable limitations), or any successor statute. During such time as Tenant is in Default, if Landlord has not terminated this Lease by written notice
and if Tenant requests Landlord’s consent to an assignment of this Lease or a sublease of the Premises, subject to Landlord’s option to recapture pursuant to Section 10.02, Landlord shall not unreasonably withhold its consent to such
assignment or sublease. Tenant acknowledges and agrees that the provisions of Article Ten shall be deemed to constitute reasonable limitations of Tenant’s right to assign or sublet. Tenant acknowledges and agrees that in the absence of written
notice pursuant to Section 11.02(b) above terminating Tenant’s right to possession, no other act of Landlord shall constitute a termination of Tenant’s right to possession or an acceptance of Tenant’s surrender of the Premises,
including acts of maintenance or preservation or efforts to relet the Premises or the appointment of a receiver upon initiative of Landlord to protect Landlord’s interest under this Lease or the withholding of consent to a subletting or
assignment, or terminating a subletting or assignment, if in accordance with other provisions of this Lease. 

  (d)       In the event that Landlord seeks an injunction with respect to a breach or threatened breach by
Tenant of any of the covenants, conditions or provisions of this Lease, Tenant agrees to pay the premium for any bond required in connection with such injunction. 
   (e)       Tenant hereby waives any and all rights to relief from forfeiture, redemption or reinstatement granted by Law (including California Civil Code of Procedure
Sections 1174 and 1179) in the event of Tenant being evicted or dispossessed for any cause or in the event of Landlord obtaining possession of the Premises by reason of Tenant’s Default or otherwise; 

  (f)       When this Lease requires giving or service of a notice of Default or of a failure of Tenant to
observe or perform any covenant, condition or provision of this Lease which will constitute a Default unless Tenant so observes or performs within any applicable cure period, and so long as the notice given or served provides Tenant the longer of
any applicable cure period required by this Lease or by statute, then the giving of any equivalent or similar statutory notice, including any equivalent or similar notices required by California Code of Civil Procedure Section 1161 or any
similar or successor statute, shall replace and suffice as any notice required under this Lease. When a statute requires service of a notice in a particular manner, service of that notice (or a similar notice required by this Lease) in the manner
required by Article Twenty-four shall replace and satisfy the statutory service–of–notice procedures, except that any notice of unlawful detainer required by California Code of Civil Procedure Section 1161 or any similar or successor
statute shall be served as required by Code of Civil Procedure Section 1162 or any similar or successor statute, and for purposes of Code of Civil Procedure Section 1162 or any similar or successor statute, Tenant’s “place of
residence” and “usual place of business” shall mean the address specified by Tenant for notice pursuant to Section 1.01 of this Lease, as changed by Tenant pursuant to Article Twenty-four of this Lease. 

  (g)       The voluntary or other surrender or termination of this Lease, or a mutual termination or
cancellation thereof, shall not work a merger and shall terminate all or any existing assignments, subleases, subtenancies or occupancies permitted by Tenant, except if and as otherwise specified in writing by Landlord. 

  (h)       No delay or omission in the exercise of any right or remedy of Landlord upon any default by
Tenant, and no exercise by Landlord of its rights pursuant to Section 26.15 to perform any duty which Tenant fails timely to perform, shall impair any right or remedy or be construed as a waiver. No provision of this Lease shall be deemed
waived by Landlord unless such waiver is in a writing signed by Landlord. The waiver by Landlord of any breach of any provision of this Lease shall not be deemed a waiver of any subsequent breach of the same or any other provision of this Lease.

  

	11.03      	ATTORNEY’S FEES 

 In the event any party brings any suit or
other proceeding with respect to the subject matter or enforcement of this Lease, the prevailing party (as determined by the court, agency or other authority before which such suit or proceeding is commenced) shall, in addition to such other relief
as may be awarded, be entitled to recover attorneys’ fees, expenses and costs of investigation as actually incurred, including court costs, expert witness fees, costs and expenses of investigation, and all attorneys’ fees, costs and
expenses in any such suit or proceeding (including in any action or participation in or in connection with any case or proceeding under the Bankruptcy Code, 11 United States Code Sections 101 et seq., or any successor statutes, in
establishing or enforcing the right to indemnification, in appellate proceedings, or in connection with the enforcement or collection of any judgment obtained in any such suit or proceeding). 

 

	11.04      	BANKRUPTCY 

 The following provisions shall apply in the event of
the bankruptcy or insolvency of Tenant: 
   (a)       In connection with any proceeding under
Chapter 7 of the Bankruptcy Code where the trustee of Tenant elects to assume this Lease for the purposes of assigning it, such election or assignment, may only be made upon compliance with the provisions of (b) and (c) below, which
conditions Landlord and Tenant acknowledge to be 

  
 19 

 
commercially reasonable. In the event the trustee elects to reject this Lease then Landlord shall immediately be entitled to possession of the Premises without further obligation to Tenant or the
trustee. 
   (b)       Any election to assume this Lease under Chapter 11 or 13 of the Bankruptcy
Code by Tenant as debtor-in-possession or by Tenant’s trustee (the “Electing Party”) must provide for: 
 The Electing Party
to cure or provide to Landlord adequate assurance that it will cure all monetary defaults under this Lease within fifteen (15) days from the date of assumption and it will cure all nonmonetary defaults under this Lease within thirty
(30) days from the date of assumption. Landlord and Tenant acknowledge such condition to be commercially reasonable. 

  (c)      If the Electing Party has assumed this Lease or elects to assign Tenant’s interest under
this Lease to any other person, such interest may be assigned only if the intended assignee has provided adequate assurance of future performance (as herein defined), of all of the obligations imposed on Tenant under this Lease. 

For the purposes hereof, “adequate assurance of future performance” means that Landlord has ascertained that each of the following
conditions has been satisfied: 
 (i)       The assignee has submitted a current financial
statement, certified by its chief financial officer, which shows a net worth and working capital in amounts sufficient to assure the future performance by the assignee of Tenant’s obligations under this Lease; and 

(ii)       Landlord has obtained consents or waivers from any third parties which may be required
under a lease, mortgage, financing arrangement, or other agreement by which Landlord is bound, to enable Landlord to permit such assignment. 
 (d)       Landlord’s acceptance of rent or any other payment from any trustee, receiver, assignee, person, or other entity will not be deemed to have waived, or waive, the
requirement of Landlord’s consent, Landlord’s right to terminate this Lease for any transfer of Tenant’s interest under this Lease without such consent, or Landlord’s claim for any amount of Rent due from Tenant. 

 

	11.05      	LANDLORD’S DEFAULT 

 Landlord shall be in default hereunder in
the event Landlord has not begun and pursued with reasonable diligence the cure of any failure of Landlord to meet its obligations hereunder within thirty (30) days after the receipt by Landlord of written notice from Tenant of the alleged
failure to perform. In no event shall Tenant have the right to terminate or rescind this Lease as a result of Landlord’s default as to any covenant or agreement contained in this Lease. Tenant hereby waives such remedies of termination and
rescission and hereby agrees that Tenant’s remedies for default hereunder and for breach of any promise or inducement shall be limited to a suit for damages and/or injunction. 

ARTICLE TWELVE 
 SURRENDER OF PREMISES

  

	12.01      	IN GENERAL 

 Upon the Termination Date, Tenant shall surrender and
vacate the Premises immediately and deliver possession thereof to Landlord in a clean, good and tenantable condition, ordinary wear and tear, and damage caused by Landlord excepted. Tenant shall deliver to Landlord all keys to the Premises. Tenant
shall remove from the Premises all movable personal property of Tenant, Tenant’s trade fixtures, and subject to Section 6.03, cabling. Tenant shall be entitled to remove such Tenant Additions which at the time of their installation
Landlord and Tenant agreed may be removed by Tenant. Tenant shall also remove such other Tenant Additions as required by Landlord, including any Tenant Additions containing Hazardous Material. Tenant immediately shall repair all damage resulting
from removal of any of Tenant’s property, furnishings or Tenant Additions, shall close all floor, ceiling and roof openings and shall restore the Premises to a tenantable condition as reasonably determined by Landlord. If any of the Tenant
Additions which were installed by Tenant involved the lowering of ceilings, raising of floors or the installation of specialized wall or floor coverings or lights, then Tenant shall also be obligated to return such surfaces to their condition prior
to the commencement of this Lease. Tenant shall also be required to close any staircases or other openings between floors. In the event possession of the Premises is not delivered to Landlord when required hereunder, or if Tenant shall fail to
remove those items described above, Landlord may (but shall not be obligated to), at Tenant’s expense, remove any of such property and store, sell or otherwise deal with such property as provided in Section 11.02(b), including the waiver
and indemnity obligations provided in that Section, and undertake, at Tenant’s expense, such restoration work as Landlord deems necessary or advisable. 
  

	12.02      	LANDLORD’S RIGHTS 

 All property which may be removed from the
Premises by Landlord shall be conclusively presumed to have been abandoned by Tenant and Landlord may deal with such property as provided in Section 11.02(b), including the waiver and indemnity obligations provided in that Section. Tenant shall
also reimburse Landlord for all costs and expenses incurred by Landlord in removing any of Tenant Additions and in restoring the Premises to the condition required by this Lease at the Termination Date. 

  
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 ARTICLE THIRTEEN 

HOLDING OVER 
 Tenant shall pay Landlord the greater
of (i) double the monthly Rent payable for the month immediately preceding the holding over (including increases for Rent Adjustments which Landlord may reasonably estimate) or, (ii) double the fair market rental value of the Premises as
reasonably determined by Landlord for each month or portion thereof that Tenant retains possession of the Premises, or any portion thereof, after the Termination Date (without reduction for any partial month that Tenant retains possession). Tenant
shall also pay all damages sustained by Landlord by reason of such retention of possession. The provisions of this Article shall not constitute a waiver by Landlord of any re-entry rights of Landlord and Tenant’s continued occupancy of the
Premises shall be as a tenancy in sufferance. If Tenant retains possession of the Premises, or any part thereof for thirty (30) days after the Termination Date then at the sole option of Landlord expressed by written notice to Tenant, but not
otherwise, such holding over shall constitute an extension of the Term of this Lease for a period of one (1) year on the same terms and conditions (including those with respect to the payment of Rent) as provided in this Lease, except that the
Monthly Base Rent for such period shall be equal to the greater of (i) 150% of the Monthly Base Rent payable during the month preceding the Termination Date, or (ii) 150% of the monthly base rent then being quoted by Landlord for similar
space in the Building. 
 ARTICLE FOURTEEN 
 DAMAGE BY FIRE OR OTHER CASUALTY 
  

	14.01      	SUBSTANTIAL UNTENANTABILITY 

  (a)       If any fire or other casualty (whether insured or uninsured) renders all or a substantial
portion of the Premises or the Building untenantable, Landlord shall, with reasonable promptness after the occurrence of such damage, estimate the length of time that will be required to substantially complete the repair and restoration and shall by
notice advise Tenant of such estimate (“Landlord’s Notice”). If Landlord estimates that the amount of time required to substantially complete such repair and restoration will exceed one hundred eighty (180) days from the date
such damage occurred, then Landlord, or Tenant if all or a substantial portion of the Premises is rendered untenantable, shall have the right to terminate this Lease as of the date of such damage upon giving written notice to the other at any time
within twenty (20) days after delivery of Landlord’s Notice, provided that if Landlord so chooses, Landlord’s Notice may also constitute such notice of termination. 

  (b)       In the event that the Building is damaged or destroyed to the extent of more than twenty-five
percent (25%) of its replacement cost or to any extent if no insurance proceeds or insufficient insurance proceeds are receivable by Landlord, or if the buildings at the Project shall be damaged to the extent of fifty percent (50%) or more
of the replacement value or to any extent if no insurance proceeds or insufficient insurance proceeds are receivable by Landlord, and regardless of whether or not the Premises be damaged, Landlord may elect by written notice to Tenant given within
thirty (30) days after the occurrence of the casualty to terminate this Lease in lieu of so restoring the Premises, in which event this Lease shall terminate as of the date specified in Landlord’s notice, which date shall be no later than
sixty (60) days following the date of Landlord’s notice. 
   (c)       Unless this
Lease is terminated as provided in the preceding Subsections 14.01 (a) and (b), Landlord shall proceed with reasonable promptness to repair and restore the Premises to its condition as existed prior to such casualty, subject to reasonable
delays for insurance adjustments and Force Majeure delays, and also subject to zoning Laws and building codes then in effect. Landlord shall have no liability to Tenant, and Tenant shall not be entitled to terminate this Lease if such repairs and
restoration are not in fact completed within the time period estimated by Landlord so long as Landlord shall proceed with reasonable diligence to complete such repairs and restoration. 

  (d)       Tenant acknowledges that Landlord shall be entitled to the full proceeds of any insurance
coverage, whether carried by Landlord or Tenant, for damages to the Premises, except for those proceeds of Tenant’s insurance of its own personal property and equipment which would be removable by Tenant at the Termination Date. All such
insurance proceeds shall be payable to Landlord whether or not the Premises are to be repaired and restored, provided, however, if this Lease is not terminated and the parties proceed to repair and restore Tenant Additions at Tenant’s cost, to
the extent Landlord received proceeds of Tenant’s insurance covering Tenant Additions, such proceeds shall be applied to reimburse Tenant for its cost of repairing and restoring Tenant Additions. 

  (e)       Notwithstanding anything in this Article Fourteen to the contrary: (i) Landlord shall have
no duty pursuant to this Section to repair or restore any portion of any Tenant Additions or to expend for any repair or restoration of the Premises or Building amounts in excess of insurance proceeds paid to Landlord and available for repair or
restoration; (ii) Tenant shall not have the right to terminate this Lease pursuant to this Section if any damage or destruction was caused by the willful and wrongful act of Tenant, its agent or employees; and (iii) in the event that the
Premises is located in more than one building of the Project and any damage or destruction covered by this Article affects only one of the buildings in which the Premises is located, then the determination of the extent of damage or destruction
shall be made only with respect to the building so affected, and Landlord or Tenant shall be entitled to terminate this Lease only with respect to the part of the Premises in the building so affected, and the Lease shall continue in full force and
effect to the extent of the remainder, if any, of the Premises. Whether or not the Lease is terminated pursuant to this Article Fourteen, in no event shall Tenant be entitled to any compensation or damages for loss of the use of the whole or any
part of the Premises or for any inconvenience or annoyance occasioned by any such damage, destruction, rebuilding or restoration of the Premises or the Building or access thereto. 

  
 21 

  

  (f)       Any repair or restoration of the Premises performed by Tenant shall be in accordance with the
provisions of Article Nine hereof. 
  

	14.02      	INSUBSTANTIAL UNTENANTABILITY 

 Unless this Lease is terminated as
provided in the preceding Subsections 14.01 (a) and (b), then Landlord shall proceed to repair and restore the Building or the Premises other than Tenant Additions, with reasonable promptness, unless such damage is to the Premises and occurs
during the last six (6) months of the Term, in which event either Tenant or Landlord shall have the right to terminate this Lease as of the date of such casualty by giving written notice thereof to the other within twenty (20) days after
the date of such casualty. Notwithstanding the foregoing, Landlord’s obligation to repair shall be limited in accordance with the provisions of Section 14.01 above. 

 

	14.03      	RENT ABATEMENT 

 If all or any part of the Premises are rendered
untenantable by fire or other casualty and this Lease is not terminated, Monthly Base Rent and Rent Adjustments shall abate for that part of the Premises which is untenantable on a per diem basis from the date of the casualty until Landlord has
Substantially Completed the repair and restoration work in the Premises which it is required to perform, provided, that as a result of such casualty, Tenant does not occupy the portion of the Premises which is untenantable during such period. The
foregoing rent abatement shall not apply in the event the Premises are rendered untenantable by reason of a fire or other casualty caused in whole or in part by the negligence or willful act of Tenant or its agents, employees, contractors or
invitees if such abatement would adversely affect Landlord’s or Tenant’s ability to collect under any of its insurance policies providing coverage for rental or business interruptions. 

 

	14.04      	WAIVER OF STATUTORY REMEDIES 

 The provisions of this Lease,
including this Article Fourteen, constitute an express agreement between Landlord and Tenant with respect to any and all damage to, or destruction of, the Premises or the Property or any part of either, and any Law, including Sections 1932(2),
1933(4), 1941 and 1942 of the California Civil Code, with respect to any rights or obligations concerning damage or destruction shall have no application to this Lease or to any damage to or destruction of all or any part of the Premises or the
Property or any part of either, and are hereby waived. 
 ARTICLE FIFTEEN 

EMINENT DOMAIN 

15.01         TAKING OF WHOLE OR SUBSTANTIAL PART 
 In the event the whole or any substantial part of the Building or of the Premises is taken or condemned by any competent authority for any public use or purpose (including a deed given in lieu of condemnation) and
is thereby rendered untenantable, this Lease shall terminate as of the date title vests in such authority or any earlier date on which possession is required to be surrendered to such authority, and Monthly Base Rent and Rent Adjustments shall be
apportioned as of the Termination Date. Notwithstanding anything to the contrary herein set forth, in the event that the Premises is located in more than one building of the Project and any taking covered by this Article affects only one of the
buildings in which the Premises is located, then the determination of the extent of the taking shall be made only with respect to the building so affected, and Landlord or Tenant shall be entitled to terminate this Lease only with respect to the
part of the Premises in the building so affected, and the Lease shall continue in full force and effect to the extent of the remainder, if any, of the Premises. Further, if at least twenty-five percent (25%) of the rentable area of the Project
is taken or condemned by any competent authority for any public use or purpose (including a deed given in lieu of condemnation), and regardless of whether or not the Premises be so taken or condemned, Landlord may elect by written notice to Tenant
to terminate this Lease as of the date title vests in such authority or any earlier date on which possession is required to be surrendered to such authority, and Monthly Base Rent and Rent Adjustments shall be apportioned as of the Termination Date.
Landlord may, without any obligation to Tenant, agree to sell or convey to the taking authority the Premises, the Building, Tenant’s Phase, the Project or any portion thereof sought by the taking authority, free from this Lease and the right of
Tenant hereunder, without first requiring that any action or proceeding be instituted or, if instituted, pursued to a judgment. Notwithstanding anything to the contrary herein set forth, in the event the taking of the Building or Premises is
temporary (for less than the remaining term of the Lease), Landlord may elect either (i) to terminate this Lease or (ii) permit Tenant to receive the entire award attributable to the Premises in which case Tenant shall continue to pay Rent
and this Lease shall not terminate. 
  

	15.02      	TAKING OF PART 

 In the event a part of the Building or the Premises
is taken or condemned by any competent authority (or a deed is delivered in lieu of condemnation) and this Lease is not terminated, the Lease shall be amended to reduce or increase, as the case may be, the Monthly Base Rent and Tenant’s Share
to reflect the Rentable Area of the Premises or Building, as the case may be, remaining after any such taking or condemnation. Landlord, upon receipt and to the extent of the award in condemnation (or proceeds of sale) shall make necessary repairs
and restorations to the Premises (exclusive of Tenant Additions) and to the Building to the extent necessary to constitute the portion of the Building not so taken or condemned as a complete architectural and economically efficient unit.
Notwithstanding the foregoing, if as a result of any taking, or a governmental order that the grade of any street or alley adjacent to the Building is to be changed and such taking or change of grade makes it necessary or desirable to substantially
remodel or restore the Building or prevents the economical operation of the Building, Landlord shall have the right to terminate this Lease upon ninety (90) days prior written notice to Tenant. 

  
 22 

  

	15.03      	COMPENSATION 

 Landlord shall be entitled to receive the entire
award (or sale proceeds) from any such taking, condemnation or sale without any payment to Tenant, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such award; provided, however, Tenant shall have the right separately to
pursue against the condemning authority a separate award in respect of the loss, if any, to Tenant Additions paid for by Tenant without any credit or allowance from Landlord, for fixtures or personal property of Tenant, or for relocation or business
interruption expenses, so long as there is no diminution of Landlord’s award as a result. 
 ARTICLE SIXTEEN 

INSURANCE 
  

	16.01      	TENANT’S INSURANCE 

 Tenant, at Tenant’s expense, agrees
to maintain in force, with a company or companies acceptable to Landlord, during the Term: (a) Commercial General Liability Insurance on a primary basis and without any right of contribution from any insurance carried by Landlord covering the
Premises on an occurrence basis against all claims for personal injury, bodily injury, death and property damage, including contractual liability covering the indemnification provisions in this Lease. Such insurance shall be for such limits that are
reasonably required by Landlord from time to time but not less than a combined single limit of Three Million and No/100 Dollars ($3,000,000.00); (b) Workers’ Compensation and Employers’ Liability Insurance to the extent required by
and in accordance with the Laws of the State of California; (c) “All Risks” property insurance in an amount adequate to cover the full replacement cost of all Tenant Additions to the Premises, equipment, installations, fixtures and
contents of the Premises in the event of loss; (d) In the event a motor vehicle is to be used by Tenant in connection with its business operation from the Premises, Comprehensive Automobile Liability Insurance coverage with limits of not less
than One Million and No/100 Dollars ($1,000,000.00) combined single limit coverage against bodily injury liability and property damage liability arising out of the use by or on behalf of Tenant, its agents and employees in connection with this
Lease, of any owned, non-owned or hired motor vehicles; and (e) such other insurance or coverages as Landlord reasonably requires. 
  

	16.02      	FORM OF POLICIES 

 Each policy referred to in 16.01 shall satisfy
the following requirements. Each policy shall (i) name Landlord and the Indemnitees as additional insureds (except Workers’ Compensation, Hired/Non-owned Automobile and Employers’ Liability Insurance), (ii) be issued by one or
more responsible insurance companies licensed to do business in the State of California reasonably satisfactory to Landlord, (iii) where applicable, provide for deductible amounts satisfactory to Landlord and not permit co-insurance,
(iv) shall provide that such insurance may not be canceled or amended without thirty (30) days’ prior written notice to the Landlord, and (v) each policy of “All-Risks” property insurance shall provide that the policy
shall not be invalidated should the insured waive in writing prior to a loss, any or all rights of recovery against any other party for losses covered by such policies. Tenant shall deliver to Landlord, certificates of insurance and at
Landlord’s request, copies of all policies and renewals thereof to be maintained by Tenant hereunder, not less than ten (10) days prior to the Commencement Date and not less than ten (10) days prior to the expiration date of each
policy. 
  

	16.03      	LANDLORD’S INSURANCE 

 Landlord agrees to purchase and keep in
full force and effect during the Term hereof, including any extensions or renewals thereof, insurance under policies issued by insurers of recognized responsibility, qualified to do business in the State of California on the Building in amounts not
less than the greater of eighty (80%) percent of the then full replacement cost (without depreciation) of the Building (above foundations and excluding Tenant Additions to the Premises) or an amount sufficient to prevent Landlord from becoming
a co-insurer under the terms of the applicable policies, against fire and such other risks as may be included in standard forms of all risk coverage insurance reasonably available from time to time. Landlord agrees to maintain in force during the
Term, Commercial General Liability Insurance covering the Building on an occurrence basis against all claims for personal injury, bodily injury, death and property damage. Such insurance shall be for a combined single limit of Three Million and
No/100 Dollars ($3,000,000.00). Neither Landlord’s obligation to carry such insurance nor the carrying of such insurance shall be deemed to be an indemnity by Landlord with respect to any claim, liability, loss, cost or expense due, in whole or
in part, to Tenant’s negligent acts or omissions or willful misconduct. Without obligation to do so, Landlord may, in its sole discretion from time to time, carry insurance in amounts greater and/or for coverage additional to the coverage and
amounts set forth above. 
  

	16.04      	WAIVER OF SUBROGATION 

              (a)       Landlord agrees that, if obtainable at
no, or minimal, additional cost, and so long as the same is permitted under the laws of the State of California, it will include in its “All Risks” policies appropriate clauses pursuant to which the insurance companies (i) waive all
right of subrogation against Tenant with respect to losses payable under such policies and/or (ii) agree that such policies shall not be invalidated should the insured waive in writing prior to a loss any or all right of recovery against any
party for losses covered by such policies. 
   (b)       Tenant agrees to include, if obtainable
at no, or minimal, additional cost, and so long as the same is permitted under the laws of the State of California, in its “All Risks” insurance policy or policies on Tenant Additions to the Premises, whether or not removable, and on
Tenant’s furniture, furnishings, fixtures and other property removable by Tenant under the provisions of this Lease appropriate clauses pursuant to which the insurance company or companies (i) waive the right of subrogation against
Landlord and/or any tenant of space in the Building with respect to losses payable under such policy or policies and/or (ii) agree that such policy or policies shall not be invalidated should the insured waive in writing prior to a loss any or
all right of recovery against any party for losses covered by such policy or policies. If Tenant is unable to obtain in such policy or policies either of the clauses described in the preceding sentence, Tenant shall, if legally possible and without
necessitating a change in insurance carriers, have Landlord named in such policy or policies as an additional insured. If Landlord shall be named as an additional insured in accordance with the foregoing, Landlord agrees to endorse promptly to the
order of Tenant, without recourse, any check, draft, or order for the payment of money representing the proceeds of any such policy or representing any other payment growing out of or connected with said policies, and Landlord does hereby
irrevocably waive any and all rights in and to such proceeds and payments. 

  
 23 

  

  (c)       Provided that Landlord’s right of full recovery under its policy or policies aforesaid is
not adversely affected or prejudiced thereby, Landlord hereby waives any and all right of recovery which it might otherwise have against Tenant, its servants, agents and employees, for loss or damage occurring to the Real Property and the fixtures,
appurtenances and equipment therein, except Tenant Additions, to the extent the same is covered by Landlord’s insurance, notwithstanding that such loss or damage may result from the negligence or fault of Tenant, its servants, agents or
employees. Provided that Tenant’s right of full recovery under its aforesaid policy or policies is not adversely affected or prejudiced thereby, Tenant hereby waives any and all right of recovery which it might otherwise have against Landlord,
its servants, and employees and against every other tenant in the Real Property who shall have executed a similar waiver as set forth in this Section 16.04 (c) for loss or damage to Tenant Additions, whether or not removable, and to
Tenant’s furniture, furnishings, fixtures and other property removable by Tenant under the provisions hereof to the extent the same is covered or coverable by Tenant’s insurance required under this Lease, notwithstanding that such loss or
damage may result from the negligence or fault of Landlord, its servants, agents or employees, or such other tenant and the servants, agents or employees thereof. 
   (d)       Landlord and Tenant hereby agree to advise the other promptly if the clauses to be included in their respective insurance policies pursuant to subparagraphs
(a) and (b) above cannot be obtained on the terms hereinbefore provided and thereafter to furnish the other with a certificate of insurance or copy of such policies showing the naming of the other as an additional insured, as aforesaid.
Landlord and Tenant hereby also agree to notify the other promptly of any cancellation or change of the terms of any such policy which would affect such clauses or naming. All such policies which name both Landlord and Tenant as additional insureds
shall, to the extent obtainable, contain agreements by the insurers to the effect that no act or omission of any additional insured will invalidate the policy as to the other additional insureds. 

 

	16.05      	NOTICE OF CASUALTY 

 Tenant shall give Landlord notice in case of a
fire or accident in the Premises promptly after Tenant is aware of such event. 
 ARTICLE SEVENTEEN 

WAIVER OF CLAIMS AND INDEMNITY 
  

	17.01      	WAIVER OF CLAIMS 

 To the extent permitted by Law, Tenant releases
the Indemnitees from, and waives all claims for, damage to person or property sustained by the Tenant or any occupant of the Premises or the Property resulting directly or indirectly from any existing or future condition, defect, matter or thing in
and about the Premises or the Property, or any part of either, or any equipment or appurtenance therein, or resulting from any accident in or about the Premises or the Property, or resulting directly or indirectly from any act or neglect of any
tenant or occupant of the Property or of any other person, including Landlord’s agents and servants, except to the extent caused by the willful and wrongful act of any of the Indemnitees. If any such damage, whether to the Premises or the
Property or any part of either, or whether to Landlord or to other tenants in the Property, results from any act or neglect of Tenant, its employees, servants, agents, contractors, invitees or customers, Tenant shall be liable therefor and Landlord
may, at Landlord’s option, repair such damage and Tenant shall, upon demand by Landlord, as payment of additional Rent hereunder, reimburse Landlord within ten (10) days of demand for the total cost of such repairs, in excess of amounts,
if any, paid to Landlord under insurance covering such damages. Tenant shall not be liable for any such damage caused by its acts or neglect if Landlord or a tenant has recovered the full amount of the damage from proceeds of insurance policies and
the insurance company has waived its right of subrogation against Tenant. Notwithstanding any provision of the first sentence of this Section to the contrary, Tenant’s release of Landlord with respect to any existing condition shall not release
Landlord from any liability which Landlord has to the extent that any Hazardous Material is in existence on the Premises or the Property prior to delivery of possession of the Premises to Tenant, except to the extent that the presence of such
Hazardous Material is caused by acts or omissions of Tenant or any Tenant Parties (as defined in Article Seven) in connection with any early entry to the Premises prior to delivery of possession to Tenant. 

 

	17.02      	INDEMNITY BY TENANT 

 To the extent permitted by Law, Tenant hereby
indemnifies, and agrees to protect, defend and hold the Indemnitees harmless, against any and all actions, claims, demands, liability, costs and expenses, including attorneys’ fees and expenses for the defense thereof, arising from
Tenant’s occupancy of the Premises, from the undertaking of any Tenant Additions or repairs to the Premises, from the conduct of Tenant’s business on the Premises, or from any breach or default on the part of Tenant in the performance of
any covenant or agreement on the part of Tenant to be performed pursuant to the terms of this Lease, or from any willful act or negligence of Tenant, its agents, contractors, servants, employees, customers or invitees, in or about the Premises or
the Property or any part of either. In case of any action or proceeding brought against the Indemnitees by reason of any such claim, upon notice from Landlord, Tenant covenants to defend such action or proceeding by counsel chosen by Landlord, in
Landlord’s sole discretion. Landlord reserves the right to settle, compromise or dispose of any and all actions, 

  
 24 

 
claims and demands related to the foregoing indemnity. The foregoing indemnity shall not operate to relieve an Indemnitee of liability to the extent such liability is caused by the gross
negligence or the willful and wrongful act of such Indemnitee. Further, the foregoing indemnity is subject to and shall not diminish any waivers in effect in accordance with Section 16.04 by Landlord or its insurers to the extent of amounts, if
any, paid to Landlord under its “All-Risks” property insurance. 
  

	17.03      	WAIVER OF CONSEQUENTIAL DAMAGES 

 To the extent permitted by law,
Tenant hereby waives and releases the Indemnitees from any consequential damages, compensation or claims for inconvenience or loss of business, rents or profits as a result of any injury or damage, whether or not caused by the willful and wrongful
act of any of the Indemnitees. 
 ARTICLE EIGHTEEN 
 RULES AND REGULATIONS 
  

	18.01      	RULES 

 Tenant agrees for itself and for its subtenants, employees,
agents, and invitees to comply with all rules and regulations for use of the Premises, the Building, the Phase and the Project imposed by Landlord, as the same may be reasonably revised from time to time, including the following: (a) Tenant
shall comply with all of the requirements of Landlord’s emergency response plan, as the same may be amended from time to time; and (b) Tenant shall not place any furniture, furnishings, fixtures or equipment in the Premises in a manner so
as to obstruct the windows of the Premises to cause the Building, in Landlord’s good faith determination, to appear unsightly from the exterior. Such rules and regulations are and shall be imposed for the cleanliness, good appearance, proper
maintenance, good order and reasonable use of the Premises, the Building, the Phase and the Project and as may be necessary for the enjoyment of the Building and the Project by all tenants and their clients, customers, and employees. 

 

	18.02      	ENFORCEMENT 

 Nothing in this Lease shall be construed to impose
upon the Landlord any duty or obligation to enforce the rules and regulations as set forth above or as hereafter adopted, or the terms, covenants or conditions of any other lease as against any other tenant, and the Landlord shall not be liable to
the Tenant for violation of the same by any other tenant, its servants, employees, agents, visitors or licensees. 
 ARTICLE NINETEEN

 LANDLORD’S RESERVED RIGHTS 

Landlord shall have the following rights exercisable without notice to Tenant and without liability to Tenant for damage or injury to persons, property or business
and without being deemed an eviction or disturbance of Tenant’s use or possession of the Premises or giving rise to any claim for offset or abatement of Rent: (1) to change the Building’s name or street address upon thirty
(30) days’ prior written notice to Tenant; (2) to install, affix and maintain all signs on the exterior and/or interior of the Building; (3) to designate and/or approve prior to installation, all types of signs, window shades,
blinds, drapes, awnings or other similar items, and all internal lighting that may be visible from the exterior of the Premises; (4) upon reasonable notice to Tenant, to display the Premises to prospective purchasers at reasonable hours at any
time during the Term and to prospective tenants at reasonable hours during the last twelve (12) months of the Term; (5) to grant to any party the exclusive right to conduct any business or render any service in or to the Building, provided
such exclusive right shall not operate to prohibit Tenant from using the Premises for the purpose permitted hereunder; (6) to change the arrangement and/or location of entrances or passageways, doors and doorways, corridors, elevators, stairs,
washrooms or public portions of the Building, and to close entrances, doors, corridors, elevators or other facilities, provided that such action shall not materially and adversely interfere with Tenant’s access to the Premises or the Building;
(7) to have access for Landlord and other tenants of the Building to any mail chutes and boxes located in or on the Premises as required by any applicable rules of the United States Post Office; and (8) to close the Building after Standard
Operating Hours, except that Tenant and its employees and invitees shall be entitled to admission at all times, under such regulations as Landlord prescribes for security purposes. 

ARTICLE TWENTY 
 ESTOPPEL CERTIFICATE

  

	20.01      	IN GENERAL 

 Within fifteen (15) days after request therefor by
Landlord, Mortgagee or any prospective mortgagee or owner, Tenant agrees as directed in such request to execute an Estoppel Certificate in recordable form, binding upon Tenant, certifying (i) that this Lease is unmodified and in full force and
effect (or if there have been modifications, a description of such modifications and that this Lease as modified is in full force and effect); (ii) the dates to which Rent has been paid; (iii) that Tenant is in the possession of the
Premises if that is the case; (iv) that Landlord is not in default under this Lease, or, if Tenant believes Landlord is in default, the nature thereof in detail; (v) that Tenant has no offsets or defenses to the performance of its
obligations under this Lease (or if Tenant believes there are any offsets or defenses, a full and complete explanation thereof); (vi) that the Premises have been completed in accordance with the terms and provisions hereof, that Tenant has
accepted the Premises and the condition thereof and of all improvements thereto and has no claims against Landlord or any other party with respect thereto; (vii) that if an assignment of rents or leases has been served upon the Tenant by a
Mortgagee, Tenant will acknowledge receipt thereof and agree to be bound by the provisions thereof; (viii) that Tenant will give to the Mortgagee copies of all notices required or permitted to be given by Tenant to Landlord; and (ix) to
any other information reasonably requested. 

  
 25 

  

	20.02      	ENFORCEMENT 

 In the event that Tenant fails to deliver an Estoppel
Certificate, then such failure shall be a Default for which there shall be no cure or grace period. In addition to any other remedy available to Landlord, Landlord may impose a charge equal to $500.00 for each day that Tenant fails to deliver an
Estoppel Certificate and Tenant shall be deemed to have irrevocably appointed Landlord as Tenant’s attorney-in-fact to execute and deliver such Estoppel Certificate. 
 ARTICLE TWENTY-ONE- 
 INTENTIONALLY OMITTED 

ARTICLE TWENTY-TWO- 
 REAL ESTATE
BROKERS 
 Tenant represents that in connection with this Lease it is represented by Tenant’s Broker identified in Section 1.01 and, except for
Tenant’s Broker and Landlord’s Broker identified in Section 1.01, Tenant has not dealt with any real estate broker, sales person, or finder in connection with this Lease, and no such person initiated or participated in the negotiation
of this Lease. Tenant hereby indemnifies and agrees to protect, defend and hold Landlord and Landlord’s Broker harmless from and against all claims, losses, damages, liability, costs and expenses (including, without limitation, attorneys’
fees and expenses) by virtue of any broker, agent or other person claiming a commission or other form of compensation by virtue of alleged representation of, or dealings or discussions with, Tenant with respect to the subject matter of this Lease,
except for Landlord’s Broker and except for a commission payable to Tenant’s Broker to the extent provided for in a separate written agreement between Tenant’s Broker and Landlord’s Broker. Landlord hereby indemnifies and agrees
to protect, defend and hold Tenant harmless from and against all claims, losses, damages, liability, costs and expenses (including, without limitation, attorneys’ fees and expenses) by virtue of any broker, agent or other person claiming a
commission or other form of compensation by virtue of alleged representation of, or dealings or discussions with, Landlord with respect to the subject matter of this Lease, except for Tenant’s Broker. Tenant is not obligated to pay or fund any
amount to Landlord’s Broker, and Landlord hereby agrees to pay such commission, if any, to which Landlord’s Broker is entitled in connection with the subject matter of this Lease pursuant to Landlord’s separate written agreement with
Landlord’s Broker. Such commission shall include an amount to be shared by Landlord’s Broker with Tenant’s Broker to the extent that Tenant’s Broker and Landlord’s Broker have entered into a separate agreement between
themselves to share the commission paid to Landlord’s Broker by Landlord. The provisions of this Section shall survive the expiration or earlier termination of the Lease. 
 ARTICLE TWENTY-THREE- 
 MORTGAGEE PROTECTION 

 

	23.01      	SUBORDINATION AND ATTORNMENT 

 This Lease is and shall be expressly
subject and subordinate at all times to (i) any ground or underlying lease of the Real Property, now or hereafter existing, and all amendments, extensions, renewals and modifications to any such lease, and (ii) the lien of any mortgage or
trust deed now or hereafter encumbering fee title to the Real Property and/or the leasehold estate under any such lease, and all amendments, extensions, renewals, replacements and modifications of such mortgage or trust deed and/or the obligation
secured thereby, unless such ground lease or ground lessor, or mortgage, trust deed or Mortgagee, expressly provides or elects that the Lease shall be superior to such lease or mortgage or trust deed. If any such mortgage or trust deed is foreclosed
(including any sale of the Real Property pursuant to a power of sale), or if any such lease is terminated, upon request of the Mortgagee or ground lessor, as the case may be, Tenant shall attorn to the purchaser at the foreclosure sale or to the
ground lessor under such lease, as the case may be, provided, however, that such purchaser or ground lessor shall not be (i) bound by any payment of Rent for more than one month in advance except payments in the nature of security for the
performance by Tenant of its obligations under this Lease; (ii) subject to any offset, defense or damages arising out of a default of any obligations of any preceding Landlord; or (iii) bound by any amendment or modification of this Lease
made without the written consent of the Mortgagee or ground lessor; or (iv) liable for any security deposits not actually received in cash by such purchaser or ground lessor. This subordination shall be self-operative and no further certificate
or instrument of subordination need be required by any such Mortgagee or ground lessor. In confirmation of such subordination, however, Tenant shall execute promptly any reasonable certificate or instrument that Landlord, Mortgagee or ground lessor
may request. Tenant hereby constitutes Landlord as Tenant’s attorney-in-fact to execute such certificate or instrument for and on behalf of Tenant upon Tenant’s failure to do so within fifteen (15) days of a request to do so. Upon
request by such successor in interest, Tenant shall execute and deliver reasonable instruments confirming the attornment provided for herein. 
  

	23.02	MORTGAGEE PROTECTION 

 Tenant agrees to give any Mortgagee or ground
lessor, by registered or certified mail, a copy of any notice of default served upon the Landlord by Tenant, provided that prior to such notice Tenant has received notice (by way of service on Tenant of a copy of an assignment of rents and leases,
or otherwise) of the address of such Mortgagee or ground lessor. Tenant further agrees that if Landlord shall have failed to cure such default within the time provided for in this Lease, then the Mortgagee or ground lessor shall have an additional
thirty (30) days after receipt of notice thereof within which to cure such default or if such default cannot be cured within that time, then such additional notice time as may be necessary, if, within such thirty (30) days, any Mortgagee
or ground lessor has commenced and is diligently pursuing the remedies necessary to cure such default (including commencement of foreclosure proceedings or other proceedings to acquire possession of the Real Property, if necessary to effect such
cure). Such period of time shall be extended by any period within which such Mortgagee or ground lessor is 

  
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prevented from commencing or pursuing such foreclosure proceedings or other proceedings to acquire possession of the Real Property by reason of Landlord’s bankruptcy. Until the time allowed
as aforesaid for Mortgagee or ground lessor to cure such defaults has expired without cure, Tenant shall have no right to, and shall not, terminate this Lease on account of default. This Lease may not be modified or amended so as to reduce the Rent
or shorten the Term, or so as to adversely affect in any other respect to any material extent the rights of the Landlord, nor shall this Lease be canceled or surrendered, without the prior written consent, in each instance, of the ground lessor or
the Mortgagee. 
 ARTICLE TWENTY-FOUR- 
 NOTICES 
   (a)       All notices, demands or requests
provided for or permitted to be given pursuant to this Lease must be in writing and shall be personally delivered, sent by Federal Express or other reputable overnight courier service, or mailed by first class, registered or certified United States
mail, return receipt requested, postage prepaid. 
   (b)       All notices, demands or requests
to be sent pursuant to this Lease shall be deemed to have been properly given or served by delivering or sending the same in accordance with this Section, addressed to the parties hereto at their respective addresses listed in Sections 1.01(2) and
(3). 
   (c)       Notices, demands or requests sent by mail or overnight courier service as
described above shall be effective upon deposit in the mail or with such courier service. However, the time period in which a response to any such notice, demand or request must be given shall commence to run from (i) in the case of delivery by
mail, the date of receipt on the return receipt of the notice, demand or request by the addressee thereof, or (ii) in the case of delivery by Federal Express or other overnight courier service, the date of acceptance of delivery by an employee,
officer, director or partner of Landlord or Tenant. Rejection or other refusal to accept or the inability to deliver because of changed address of which no notice was given, as indicated by advice from Federal Express or other overnight courier
service or by mail return receipt, shall be deemed to be receipt of notice, demand or request sent. Notices may also be served by personal service upon any officer, director or partner of Landlord or Tenant, and shall be effective upon such service.

   (d)       By giving to the other party at least thirty (30) days written notice thereof,
either party shall have the right from time to time during the term of this Lease to change its respective addresses for notices, statements, demands and requests, provided such new address shall be within the United States of America. 

ARTICLE TWENTY-FIVE 
 EXERCISE
FACILITY 
 Tenant agrees to inform all employees of Tenant of the following: (i) the exercise facility is available for the use of the employees of
tenants of the Project only and for no other person; (ii) use of the facility is at the risk of Tenant or Tenant’s employees, and all users must sign a release; (iii) the facility is unsupervised; and (iv) users of the facility
must report any needed equipment maintenance or any unsafe conditions to the Landlord immediately. Landlord may discontinue providing such facility at Landlord’s sole option at any time without incurring any liability. As a condition to the use
of the exercise facility, Tenant and each of Tenant’s employees that uses the exercise facility shall first sign a written release in form and substance acceptable to Landlord. Landlord may change the rules and/or hours of the exercise facility
at any time, and Landlord reserves the right to deny access to the exercise facility to anyone due to misuse of the facility or noncompliance with rules and regulations of the facility. To the extent permitted by Law, Tenant hereby indemnifies, and
agrees to protect, defend and hold the Indemnitees harmless, against any and all actions, claims, demands, liability, costs and expenses, including attorneys’ fees and expenses for the defense thereof, arising from use of the exercise facility
in the Project by Tenant, Tenant’s employees or invitees. In case of any action or proceeding brought against the Indemnitees by reason of any such claim, upon notice from Landlord, Tenant covenants to defend such action or proceeding by
counsel chosen by Landlord, in Landlord’s sole discretion. Landlord reserves the right to settle, compromise or dispose of any and all actions, claims and demands related to the foregoing indemnity. 

ARTICLE TWENTY-SIX- 
 MISCELLANEOUS

  

	26.01      	LATE CHARGES 

  (a)       The Monthly Base Rent, Rent Adjustments and Rent Adjustment Deposits shall be due when and as
specifically provided above. Except for such payments and late charges described below, which late charge shall be due when provided below (without notice or demand), all other payments required hereunder to Landlord shall be paid within ten
(10) days after Landlord’s demand therefor. All Rent and charges, except late charges, not paid when due shall bear interest from the date due until the date paid at the Default Rate in effect on the date such payment was due. 

  (b)       In the event Tenant is more than five (5) days late in paying any installment of Rent due
under this Lease, Tenant shall pay Landlord a late charge equal to five percent (5%) of the delinquent installment of Rent. The parties agree that (i) such delinquency will cause Landlord to incur costs and expenses not contemplated
herein, the exact amount of which will be difficult to calculate, including the cost and expense that will be incurred by Landlord in processing each delinquent payment of rent by Tenant, and (ii) the amount of such late charge represents a
reasonable estimate of such costs and expenses and that such late charge shall be paid to Landlord for each delinquent payment in addition to all Rent otherwise due hereunder. The parties further agree that the payment of late charges and the
payment of interest provided for in subparagraph (a) above are distinct and separate from one another in that the payment of interest is to compensate Landlord for its inability to use the money improperly withheld by Tenant, while the payment
of late charges is to compensate Landlord for its additional administrative expenses in handling and processing delinquent payments. 

  
 27 

  
   (c) Payment of
interest at the Default Rate and/or of late charges shall not excuse or cure any default by Tenant under this Lease, nor shall the foregoing provisions of this Article or any such payments prevent Landlord from exercising any right or remedy
available to Landlord upon Tenant’s failure to pay Rent when due, including the right to terminate this Lease. 
  

	26.02      	NO JURY TRIAL; VENUE; JURISDICTION 

 To the extent permitted by Law,
each party hereto (which includes any assignee, successor, heir or personal representative of a party) shall not seek a jury trial, hereby waives trial by jury, and hereby further waives any objection to venue in the County in which the Project is
located, and agrees and consents to personal jurisdiction of the courts of the State of California, in any action or proceeding or counterclaim brought by any party hereto against the other on any matter whatsoever arising out of or in any way
connected with this Lease, the relationship of Landlord and Tenant, Tenant’s use or occupancy of the Premises, or any claim of injury or damage, or the enforcement of any remedy under any statute, emergency or otherwise, whether any of the
foregoing is based on this Lease or on tort law. No party will seek to consolidate any such action in which a jury has been waived with any other action in which a jury trial cannot or has not been waived. It is the intention of the parties that
these provisions shall be subject to no exceptions. By execution of this Lease the parties agree that this provision may be filed by any party hereto with the clerk or judge before whom any action is instituted, which filing shall constitute the
written consent to a waiver of jury trial pursuant to and in accordance with Section 631 of the California Code of Civil Procedure. No party has in any way agreed with or represented to any other party that the provisions of this Section will
not be fully enforced in all instances. The provisions of this Section shall survive the expiration or earlier termination of this Lease. 
  

	26.03      	DEFAULT UNDER OTHER LEASE 

 It shall be a Default under this Lease
if Tenant or any Affiliate holding any other lease with Landlord for premises in the Project defaults under such lease and as a result thereof such lease is terminated or terminable. 

 

	26.04      	OPTION 

 This Lease shall not become effective as a lease or
otherwise until executed and delivered by both Landlord and Tenant. The submission of the Lease to Tenant does not constitute a reservation of or option for the Premises, but when executed by Tenant and delivered to Landlord, the Lease shall
constitute an irrevocable offer by Tenant in effect for fifteen (15) days to lease the Premises on the terms and conditions herein contained. 
  

	26.05      	AUTHORITY 

 Tenant and Landlord, and each entity and individual
executing this Lease on behalf of Tenant or Landlord, represents and warrants to Landlord and Tenant, respectively, that each has full authority and power to enter into this Lease on behalf of Tenant and Landlord, respectively, and that each of
Tenant and Landlord has full power and authority to perform its obligations under this Lease, and that no consent or authorization is necessary from any third party Landlord may request that Tenant provide Landlord evidence of Tenant’s
authority. 
  

	26.06      	ENTIRE AGREEMENT 

 This Lease, the Exhibits and Riders attached
hereto contain the entire agreement between Landlord and Tenant concerning the Premises and there are no other agreements, either oral or written, and no other representations or statements, either oral or written, on which Tenant has relied. This
Lease shall not be modified except by a writing executed by Landlord and Tenant. 
  

	26.07      	MODIFICATION OF LEASE FOR BENEFIT OF MORTGAGEE 

 If Mortgagee of
Landlord requires a modification of this Lease which shall not result in any increased cost or expense to Tenant or in any other material and adverse change in the rights and obligations of Tenant hereunder, then Tenant agrees that the Lease may be
so modified. 
  

	26.08      	EXCULPATION 

 Tenant agrees, on its behalf and on behalf of its
successors and assigns, that any liability or obligation of Landlord in connection with this Lease shall only be enforced against Landlord’s equity interest in the Property up to a maximum of Five Million Dollars ($5,000,000.00) and in no event
against any other assets of the Landlord, or Landlord’s officers or directors or partners, and that any liability of Landlord with respect to this Lease shall be so limited and Tenant shall not be entitled to any judgment in excess of such
amount. 
  

	26.09      	ACCORD AND SATISFACTION 

 No payment by Tenant or receipt by
Landlord of a lesser amount than any installment or payment of Rent due shall be deemed to be other than on account of the amount due, and no endorsement or statement on any check or any letter accompanying any check or payment of Rent shall be
deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such installment or payment of Rent or pursue any other remedies available to Landlord. No receipt
of money by Landlord from Tenant 

  
 28 

 
after the termination of this Lease or Tenant’s right of possession of the Premises shall reinstate, continue or extend the Term. Receipt or acceptance of payment from anyone other than
Tenant, including an assignee of Tenant, is not a waiver of any breach of Article Ten, and Landlord may accept such payment on account of the amount due without prejudice to Landlord’s right to pursue any remedies available to Landlord.

  

	26.10      	LANDLORD’S OBLIGATIONS ON SALE OF BUILDING 

 In the event of
any sale or other transfer of the Building, Landlord shall be entirely freed and relieved of all agreements and obligations of Landlord hereunder accruing or to be performed after the date of such sale or transfer, and any remaining liability of
Landlord with respect to this Lease shall be limited to Five Million Dollars ($5,000,000.00) and Tenant shall not be entitled to any judgment in excess of such amount. 
  

	26.11      	BINDING EFFECT 

 Subject to the provisions of Article Ten, this
Lease shall be binding upon and inure to the benefit of Landlord and Tenant and their respective heirs, legal representatives, successors and permitted assigns. 
  

	26.12      	CAPTIONS 

 The Article and Section captions in this Lease are
inserted only as a matter of convenience and in no way define, limit, construe, or describe the scope or intent of such Articles and Sections. 
  

	26.13      	TIME; APPLICABLE LAW; CONSTRUCTION 

 Time is of the essence of this
Lease and each and all of its provisions. This Lease shall be construed in accordance with the Laws of the State of California. If more than one person signs this Lease as Tenant, the obligations hereunder imposed shall be joint and several. If any
term, covenant or condition of this Lease or the application thereof to any person or circumstance shall, to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such term, covenant or condition to persons or
circumstances other than those as to which it is held invalid or unenforceable, shall not be affected thereby and each item, covenant or condition of this Lease shall be valid and be enforced to the fullest extent permitted by Law. Wherever the term
“including” or “includes” is used in this Lease, it shall have the same meaning as if followed by the phrase “but not limited to”. The language in all parts of this Lease shall be construed according to its normal and
usual meaning and not strictly for or against either Landlord or Tenant. 
  

	26.14      	VACATION 

 In the event Tenant vacates or abandons the Premises but
is otherwise in compliance with all the terms, covenants and conditions of this Lease, Landlord shall have the right to enter into the Premises in order to show the space to prospective tenants. Tenant expressly acknowledges that in the absence of
written notice pursuant to Section 11.02(b) or pursuant to California Civil Code Section 1951.3 terminating Tenant’s right to possession, none of the foregoing acts of Landlord or any other act of Landlord shall constitute a
termination of Tenant’s right to possession or an acceptance of Tenant’s surrender of the Premises, and the Lease shall continue in effect. 
  

	26.15      	LANDLORD’S RIGHT TO PERFORM TENANT’S DUTIES 

 If Tenant
fails timely to perform any of its duties under this Lease and such failure continues beyond any applicable notice and cure period (except that no notice or cur period shall be required in case of emergency), Landlord shall have the right (but not
the obligation), to perform such duty on behalf and at the expense of Tenant without prior notice to Tenant, and all sums expended or expenses incurred by Landlord in performing such duty shall be deemed to be additional Rent under this Lease and
shall be due and payable upon demand by Landlord. 
  

	26.16      SECURITY	SYSTEM 

 Landlord shall not be obligated to provide or maintain any
security patrol or security system. Landlord shall not be responsible for the quality of any such patrol or system which may be provided hereunder or for damage or injury to Tenant, its employees, invitees or others due to the failure, action or
inaction of such patrol or system. 
  

	26.17      	NO LIGHT, AIR OR VIEW EASEMENTS 

 Any diminution or shutting off of
light, air or view by any structure which may be erected on lands of or adjacent to the Project shall in no way affect this Lease or impose any liability on Landlord. 
  

	26.18      	RECORDATION 

 Neither this Lease, nor any notice nor memorandum
regarding the terms hereof, shall be recorded by Tenant. Any such unauthorized recording shall be a Default for which there shall be no cure or grace period. Tenant agrees to execute and acknowledge, at the request of Landlord, a memorandum of this
Lease, in recordable form. 
  

	26.19      	SURVIVAL 

 The waivers of the right of jury trial, the other waivers
of claims or rights, the releases and the obligations of Tenant or Landlord under this Lease to indemnify, protect, defend and hold harmless others as specified in this Lease shall survive the expiration or termination of this Lease, and so shall
all other obligations or agreements which by their terms survive expiration or termination of the Lease. 

  
 29 

  

	26.20      	EXHIBITS OR RIDERS 

 All exhibits, riders and/or addenda referred to
in this Lease as an exhibit, addenda or rider hereto or attached hereto, are hereby incorporated into and made a part of this Lease. 
 IN WITNESS
WHEREOF, this Lease has been executed as of the date set forth in Section 1.01(4) hereof. 
  

					
	 TENANT:
	  	  	  	LANDLORD:
			
	 AcelRx Pharmaceuticals, Inc.,
	  		  	Metropolitan Life Insurance Company,
	 a Delaware corporation
	  		  	a New York corporation
			
	 By /s/ Thomas A.
Schreck                    
	  		  	By /s/ Greg
Hill                                    
			
	    Thomas A.
Schreck                          	  		  	    Greg
Hill                                         
 
	Print name	  		  	Print name
			
	 Its Chairman &
CEO                             
	  		  	Its
Director                                       
   
	 (Chairman of Board, President or Vice President)
	  		  	
			
	 By /s/ Carter
King                                 
	  		  	
			
	    Carter
King                                        
	  		  	
	Print name	  		  	
			
	 Its
CFO                                        
          
	  		  	
	 (Secretary, Assistant Secretary, CFO or Assistant Treasurer)

  
 30 

  
 EXHIBIT A 

PLAN OF PREMISES 

 

 

  
 Exhibit A - Page 1

  
 EXHIBIT B 

WORKLETTER AGREEMENT 
 (TENANT BUILD)

 This Workletter Agreement (“Workletter”) is attached to and a part of a certain Lease by and between Metropolitan Life
Insurance Company, a New York corporation, as Landlord, and AcelRx Pharmaceuticals, Inc., a Delaware corporation, as Tenant, for the Premises (the “Lease”). Terms used herein and not defined herein shall have the meaning of such terms as
defined elsewhere in the Lease. For purposes of this Workletter, references to “State” and “City” shall mean the State and City in which the Building is located. 

 

	 	1.	AS IS Condition; Delivery. 

 Landlord shall
deliver the Premises broom clean in its current “as built” configuration with existing build-out of the tenant space, with the Premises and the Building (including the “Base Building”, as defined below) in their AS IS condition,
without any express or implied representations or warranties of any kind by Landlord, its brokers, manager or agents, or the employees of any of them; and Landlord shall not have any obligation to construct or install any tenant improvements or
alterations or to pay for any such construction or installation except to the extent expressly provided in this Workletter. For purposes hereof, the “Base Building” (sometimes also referred to as the “Base Building Work”) shall
mean the improvements made and work performed during the Building’s initial course of construction and modifications thereto, excluding all original and modified build-outs of any tenant spaces. Notwithstanding any provision of this Workletter
or the Lease to the contrary, to the extent that any of the Building Systems (as defined in Section 3.2 below) which are part of the Base Building are not in good operating condition, except to the extent any of the foregoing are to be removed,
demolished or altered by Tenant, and within three (3) days after the Delivery Date the Tenant gives Landlord written notice specifying what is not in good operating condition, Landlord shall make necessary repairs. 

2.       Landlord Work. 
 There shall be no Landlord Work. 
 3.       Tenant’s Plans.

 3.1.    Description. At its expense, Tenant shall employ: 

(i)       one or more architects reasonably satisfactory to Landlord and licensed by the State
(“Tenant’s Architect”) to prepare architectural drawings and specifications for all layout and Premises improvements not included in, or requiring any change or addition to, the AS IS condition and Landlord Work, if any. 

(ii)       one or more engineers reasonably satisfactory to Landlord and licensed by the State
(“Tenant’s Engineers”) to prepare structural, mechanical and electrical working drawings and specifications for all Premises improvements not included in, or requiring any change or addition to, the AS IS condition and Landlord Work,
if any. 
 All such drawings and specifications are referred to herein as “Tenant’s Plans”. Tenant’s Plans shall be in form and detail
sufficient to secure all applicable governmental approvals. Tenant’s Architect shall be responsible for coordination of all engineering work for Tenant’s Plans and shall coordinate with any consultants of Tenant (the use of which is
subject to Landlord’s consent), and Landlord’s space planner or architect to assure the consistency of Tenant’s Plans with the Base Building Work and Landlord Work (if any). 
 Tenant shall pay Landlord, within ten (10) days of receipt of each invoice from Landlord, the cost incurred by Landlord for Landlord’s architects and engineers to review Tenant’s Plans for
consistency of same with the Base Building Work and Landlord Work, if any. Tenant’s Plans shall also include the following: 
 (a)       Final Space Plan: The “Final Space Plan” for the Premises shall include a full and accurate description of room titles, floor loads, alterations to the Base
Building or Landlord Work (if any) or requiring any change or addition to the AS IS condition, and the dimensions and location of all partitions, doors, aisles, plumbing (and furniture and equipment to the extent same affect floor loading). The
Final Space Plan shall (i) be compatible with the design, construction, systems and equipment of the Base Building and Landlord Work, if any; (ii) specify only materials, equipment and installations which are new and of a grade and quality
no less than existing components of the Building when they were originally installed (collectively, (i) and (ii) may be referred to as “Building Standard” or “Building Standards”); (iii) comply with Laws,
(iv) be capable of logical measurement and construction, and (v) contain all such information as may be required for the preparation of the Mechanical and Electrical Working Drawings and Specifications (including, without limitation, a
capacity and usage report, from engineers designated by Landlord pursuant to Section 3.1(b). below, for all mechanical and electrical systems in the Premises). 
         (b)       Mechanical and Electrical Working Drawings and Specifications: Tenant shall employ engineers approved by Landlord to prepare
Mechanical and Electrical Working Drawings and Specifications showing complete plans for electrical, life safety, automation, plumbing, water, and air cooling, ventilating, heating and temperature control and shall employ engineers designated by
Landlord to prepare for Landlord a capacity and usage report (“Capacity Report”) for all mechanical and electrical systems in the Premises. 
 (c)       Issued for Construction Documents: The “Issued for Construction Documents” shall consist of all drawings (1/8” scale) and specifications necessary to construct
all Premises improvements including, without limitation, architectural and structural working drawings and specifications and Mechanical and Electrical Working Drawings and Specifications and all applicable governmental authorities plan check
corrections. 

  
 Exhibit B - Page 1

  
 3.2.    
Approval by Landlord. Tenant’s Plans and any revisions thereof shall be subject to Landlord’s approval, which approval or disapproval: 
 (i)       shall not be unreasonably withheld, provided however, that Landlord may disapprove Tenant’s Plans in its sole and absolute discretion if they (a) adversely affect
the structural integrity of the Building, including applicable floor loading capacity; (b) adversely affect any of the Building Systems (as defined below), the Common Areas or any other tenant space (whether or not currently occupied);
(c) fail to fully comply with Laws, (d) affect the exterior appearance of the Building; (e) provide for improvements which do not meet or exceed the Building Standards; or (f) involve any installation on the roof, or otherwise
affect the roof, roof membrane or any warranties regarding either. Building Systems collectively shall mean the structural, electrical, mechanical (including, without limitation, heating, ventilating and air conditioning), plumbing, fire and
life-safety (including, without limitation, fire protection system and any fire alarm), communication, utility, gas (if any), and security (if any) systems in the Building. 

(ii)       shall not be delayed beyond ten (10) business days with respect to initial submissions
and major change orders (those which impact Building Systems or any other item listed in subpart (i) of Section 3.2 above) and beyond five (5) business days with respect to required revisions and any other change orders. 

If Landlord disapproves of any of Tenant’s Plans, Landlord shall advise Tenant of what Landlord disapproves in reasonable detail. After being so advised by
Landlord, Tenant shall submit a redesign, incorporating the revisions required by Landlord, for Landlord’s approval. The approval procedure shall be repeated as necessary until Tenant’s Plans are ultimately approved. Approval by Landlord
shall not be deemed to be a representation or warranty by Landlord with respect to the safety, adequacy, correctness, efficiency or compliance with Laws of Tenant’s Plans. Tenant shall be fully and solely responsible for the safety, adequacy,
correctness and efficiency of Tenant’s Plans and for the compliance of Tenant’s Plans with any and all Laws. 

3.3.       Landlord Cooperation. Landlord shall cooperate with Tenant and make good faith efforts to
coordinate Landlord’s construction review procedures to expedite the planning, commencement, progress and completion of Tenant Work. Landlord shall complete its review of each stage of Tenant’s Plans and any revisions thereof and
communicate the results of such review within the time periods set forth in Section 3.2 above. 

3.4.       City Requirements. Any changes in Tenant’s Plans which are made in response to requirements of
the applicable governmental authorities and/or changes which affect the Base Building Work shall be immediately submitted to Landlord for Landlord’s review and approval. 
 3.5.       “As-Built” Drawings and Specifications. A CADD-DXF file on diskette or CD, pdf versions of the drawings on CD, and a set of “Xerox” type blackline
on bond prints of all “as-built” drawings and specifications of the Premises (reflecting all field changes and including, without limitation, architectural, structural, mechanical and electrical drawings and specifications) prepared by
Tenant’s Architect and Engineers or by Contractors (defined below) shall be delivered by Tenant at Tenant’s expense to the Landlord within thirty (30) days after completion of the Tenant Work. If Landlord has not received such
drawings and diskette(s) within thirty (30) days, Landlord may give Tenant written notice of such failure. If Tenant does not produce such drawings and diskette(s) within ten (10) days after Landlord’s written notice, Landlord may, at
Tenant’s sole cost which may be deducted from the Allowance, produce such drawings and diskette(s) using Landlord’s personnel, managers, and outside consultants and contractors. Landlord shall receive an hourly rate reasonable for such
production. 
  

	4.	Tenant Work. 

 4.1.       Tenant Work Defined. All tenant improvement work required by the Issued for Construction
Documents (including, without limitation, any approved changes, additions or alterations pursuant to Section 7 below) is referred to in this Workletter as “Tenant Work.” 

 4.2.       Tenant to Construct. Tenant shall construct all Tenant Work pursuant to this Workletter, and
except to the extent modified by or inconsistent with express provisions of this Workletter, pursuant with the provisions of the terms and conditions of Article Nine of the Lease, governing Tenant Alterations (except to the extent modified by this
Workletter) and all such Tenant Work shall be considered “Tenant Alterations” for purposes of the Lease. 

 4.3.       Construction Contract. All contracts and subcontracts for Tenant Work shall include any terms
and conditions required by Landlord. 
  4.4.       Contractor. Tenant shall select one or more
contractors to perform the Tenant Work (“Contractor”) subject to Landlord’s prior written approval, which shall not unreasonably be withheld. 
  4.5.       Division of Landlord Work and Tenant Work. Tenant Work is defined in Section 4.1. above and Landlord Work, if any, is defined in Section 2.

  
 Exhibit B - Page 2

  

	5.	Tenant’s Expense; Allowance. 

 Tenant agrees to pay for
all Tenant Work, including, without limitation, the costs of design thereof, whether or not all such costs are included in the “Permanent Improvement Costs” (defined below). Subject to the terms and conditions of this Workletter, Tenant
shall apply the “Allowance” (defined below) to payment of the Permanent Improvement Costs. The term “Permanent Improvement Costs” shall mean the actual and reasonable costs of construction of that Tenant Work which constitutes
permanent improvements to the Premises, actual and reasonable costs of design thereof and governmental permits therefor, costs incurred by Landlord for Landlord’s architects and engineers pursuant to Section 3.1, and Landlord’s
construction administration fee (defined in Section 8.10 below). Provided, however, Permanent Improvement Costs shall exclude costs of “Tenant’s FF& E” (defined below). For purposes of this Workletter, “Tenant’s
FF& E” shall mean furniture, furnishings, telephone systems, computer systems, equipment, any other personal property, and installation thereof. Notwithstanding any provision of this Workletter or Lease to the contrary, for purposes of this
Workletter and Lease, all property which becomes attached to the Premises or Building, including any part of any laboratory or laboratories for pharmaceutical, life sciences or related purposes (for example and without limitation, laboratory
benches, counters, sinks, hoods, ventilation systems, or heating, ventilating or air-conditioning systems): (a) shall not be deemed to be personal property, fixtures or trade fixtures, but shall be deemed to be Tenant Work (and Tenant
Additions) and part of the permanent improvements to the Premises or Building at the time of their installation, whether installed by or paid for by Landlord or Tenant, shall without compensation or credit to Tenant remain in the Premises and the
Building; and (b) the costs thereof shall be deemed to be Permanent Improvement Costs reimbursable out of the Allowance. Landlord shall provide Tenant a tenant improvement allowance (“Allowance”) in the amount equal to Sixty-six and
00/100 Dollars ($66.00) per square foot of the Rentable Area of the Premises. The Allowance shall be used solely to reimburse Tenant for the Permanent Improvement Costs. If Tenant does not utilize one hundred percent (100%) of the Allowance for
Permanent Improvement Costs within six (6) months after the Delivery Date of the Premises, Tenant shall have no right to the unused portion of the Allowance. 
  

	6.	Application and Disbursement of the Allowance. 

 6.1.       Tenant shall prepare a budget for all Tenant Work, including the Permanent Improvement Costs and all other costs of the Tenant Work (“Budget”), which Budget shall
be subject to the reasonable approval of Landlord. Such Budget shall be supported by a guaranteed maximum price construction contract and such other documentation as Landlord may require to evidence the total costs. To the extent the Budget exceeds
the available Allowance (“Excess Cost”), Tenant shall be solely responsible for payment of such Excess Cost. Further, prior to any disbursement of the Allowance by Landlord, Tenant shall pay and disburse its own funds for all that portion
of the Permanent Improvement Costs equal to the sum of (a) the Permanent Improvement Costs in excess of the Allowance; plus (b) the amount of “Landlord’s Retention” (defined below). “Landlord’s Retention”
shall mean an amount equal to fifteen percent (15%) of the Allowance, which Landlord shall retain out of the Allowance and shall not be obligated to disburse unless and until after Tenant has completed the Tenant Work and complied with
Section 6.4 below. Further, Landlord shall not be obligated to make any disbursement of the Allowance unless and until Tenant has provided Landlord with (a) bills and invoices covering all labor and material expended and used, (b) an
affidavit from Tenant stating that all of such bills and invoices have either been paid in full by Tenant or are due and owing, and all such costs qualify as Permanent Improvement Costs, (c) contractors affidavit covering all labor and
materials expended and used, (d) Tenant, contractors and architectural completion affidavits (as applicable), and (e) valid mechanics’ lien releases and waivers pertaining to any completed portion of the Tenant Work which shall be
conditional or unconditional, as applicable, all as provided pursuant to Section 6.2 and 6.4 below. 

6.2.       Upon Tenant’s full compliance with the provisions of Section 6, and if Landlord determines that
there are no applicable or claimed stop notices (or any other statutory or equitable liens of anyone performing any of Tenant Work or providing materials for Tenant Work) or actions thereon, Landlord shall disburse the applicable portion of the
Allowance as follows: 
 (a)       In the event of conditional releases, to the respective
contractor, subcontractor, vendor, or other person who has provided labor and/or services in connection with the Tenant Work, upon the following terms and conditions: (i) such costs are included in the Budget, are Permanent Improvement Costs,
are covered by the Allowance, and Tenant has completed and delivered to Landlord a written request for payment, in form reasonably approved by Landlord, setting forth the exact name of the contractor, subcontractor or vendor to whom payment is to be
made and the date and amount of the bill or invoice, (ii) the request for payment is accompanied by the documentation set forth in Section 6.1; and (iii) Landlord, or Landlord’s appointed representative, has inspected and
approved the work for which Tenant seeks payment; or 

        (b)       In the event of unconditional releases, directly to Tenant
upon the following terms and conditions: (i) Tenant seeks reimbursement for costs of Tenant Work which have been paid by Tenant, are included in the Budget, are Permanent Improvement Costs, and are covered by the Allowance; (ii) Tenant has
completed and delivered to Landlord a request for payment, in form reasonably approved by Landlord, setting forth the name of the contractor, subcontractor or vendor paid and the date of payment, (iii) the request for payment is accompanied by
the documentation set forth in Section 6.1; and (iv) Landlord, or Landlord’s appointed representative, has inspected and approved the work for which Tenant seeks reimbursement. 
             6.3.       Tenant shall provide Landlord with the aforementioned documents by the 15th of the month and payment
shall be made by the 30th day of the month following the month in which such documentation is provided. 

6.4.       Prior to Landlord disbursing the Landlord’s Retention to Tenant, Tenant shall submit to Landlord the
following items within thirty (30) days after completion of the Tenant Work: (i) “As Built” drawings and specifications pursuant to Section 3.5 above, (ii) all unconditional lien releases from all general contractor(s)
and subcontractor(s) performing work, (iii) a “Certificate of Completion” prepared by Tenant’s Architect, and (iv) a final budget with supporting documentation detailing all costs associated with the Permanent Improvement
Costs. 

  
 Exhibit B - Page 3

  

	7.	Changes, Additions or Alterations. 

 If
Tenant desires to make any non-de minimis change, addition or alteration or desires to make any change, addition or alteration to any of the Building Systems after approval of the Issued for Construction Documents, Tenant shall prepare and submit to
Landlord plans and specifications with respect to such change, addition or alteration. Any such change, addition or alteration shall be subject to Landlord’s approval in accordance with the provisions of Section 3.2 of this Workletter.
Tenant shall be responsible for any submission to and plan check and permit requirements of the applicable governmental authorities. Tenant shall be responsible for payment of the cost of any such change, addition or alteration if it would increase
the Budget and Excess Cost previously submitted and approved pursuant to Section 6 above. 
  

	8.	Miscellaneous. 

8.1.       Scope. Except as otherwise set forth in the Lease, this Workletter shall not apply to any space
added to the Premises by Lease option or otherwise. 
 8.2.       Tenant Work shall include (at Tenant’s
expense) for all of the Premises: 
 (a)       Landlord approved lighting sensor controls as necessary to
meet applicable Laws; 
 (b)       Building Standard fluorescent fixtures in all Building office areas;

 (c)       Building Standard meters for each of electricity and chilled water used by Tenant shall be
connected to the Building’s system and shall be tested and certified prior to Tenant’s occupancy of the Premises by a State certified testing company; 
 (d)       Building Standard ceiling systems (including tile and grid) and; 
 (e)       Building Standard air conditioning distribution and Building Standard air terminal units. 
 8.3.       Sprinklers. Subject to any terms, conditions and limitations set forth herein, Landlord shall provide an operative sprinkler system consisting of mains, laterals, and heads
“AS IS” on the date of delivery of the Premises to Tenant. Tenant shall pay for piping distribution, drops and relocation of, or additional, sprinkler system heads and Building firehose or firehose valve cabinets, if Tenant’s Plans
and/or any applicable Laws necessitate such. 
 8.4.       Floor Loading. Floor loading capacity
shall be within building design capacity. Tenant may exceed floor loading capacity with Landlord’s consent, at Landlord’s sole discretion and must, at Tenant’s sole cost and expense, reinforce the floor as required for such excess
loading. 
 8.5.       Work Stoppages. If any work on the Real Property other than Tenant Work is
delayed, stopped or otherwise affected by construction of Tenant Work, Tenant shall immediately take those actions necessary or desirable to eliminate such delay, stoppage or effect on work on the Real Property other than Tenant Work. 

8.6.       Life Safety. Tenant (or Contractor) shall employ the services of a fire and life-safety
subcontractor reasonably satisfactory to Landlord for all fire and life-safety work at the Building. 

8.7.       Locks. Tenant agrees to purchase from Landlord or its representative all cylinders and keys used in
locks used in the Premises. 
 8.8.       Authorized Representatives. Tenant has designated Carter
King to act as Tenant’s representative with respect to the matters set forth in this Workletter. Such representative(s) shall have full authority and responsibility to act on behalf of Tenant as required in this Workletter. Tenant may add or
delete authorized representatives upon five (5) business days notice to Landlord. 
 8.9.      
Access to Premises. After Landlord has recovered possession of the Premises from any prior Tenant, prior to delivery of possession to Tenant, Tenant and its architects, engineers, consultants, and contractors shall have access at reasonable
times and upon advance notice and coordination with the Building management, to the Premises for the purpose of planning Tenant Work. Such access shall not in any manner interfere with Landlord Work, if any. Such access, and all acts and omissions
in connection with it, shall be subject to and governed by all other provisions of the Lease, including, without limitation, Tenant’s indemnification obligations, insurance obligations, etc, except for the payment of Base Rent and Additional
Rent. To the extent that such access by Tenant delays the Substantial Completion of the Landlord Work (if any), such delay shall be a Tenant Delay and the Landlord Work shall be deemed Substantially Complete on the date such Landlord Work would have
been completed but for such access. 
 8.10.       Fee. Landlord shall receive a fee equal to one
percent (1.0%) of Tenant’s construction contract for all costs, including, without limitation, materials, labor, supervision, profit, overhead or general conditions in connection with the construction of the Tenant Work. Such fee is in
addition to Tenant’s reimbursement of costs incurred by Landlord pursuant to other provisions hereof, including, without limitation, for Landlord’s architects and engineers to review Tenant’s Plans. 

  
 Exhibit B - Page 4

  

	9.	Force and Effect. 

 The terms and conditions
of this Workletter shall be construed to be a part of the Lease and shall be deemed incorporated in the Lease by this reference. Should any inconsistency arise between this Workletter and the Lease as to the specific matters which are the subject of
this Workletter, the terms and conditions of this Workletter shall control. 

  
 Exhibit B - Page 5

  
 EXHIBIT C 

SITE PLAN OF PROJECT 

 

 

  
 Exhibit C - Page 1

  
 EXHIBIT D 

PERMITTED HAZARDOUS MATERIAL 
 Permitted Hazardous
Material shall mean the substances listed below in the quantity which is the lesser of (a) the amount reasonably necessary for Tenant’s day to day operations in the Premises permitted by this Lease and by Environmental Law, or (b) the
quantity limit specified below. 
  

							
	List of Chemicals	  	 Quantity
 on Hand
	  	Manufacturer	  	Part Number
				
	 Ethanol – Hazard Class 3
	  	13.2 gal.	  	VWR	  	EM-AX0441-3
	 Hydrochloric Acid – Hazard Class 8
	  	1.3 gal.	  		  	
	 Isopropyl Alcohol – Hazard Class 3
	  	3.2 gal.	  		  	
	 Methanol – Hazard Class 3
	  	2.6 gal.	  		  	
				
	 Nitrogen, compressed
	  	600 cu ft	  		  	
				
	 Sodium Hydroxide – Class 8
	  	4.4 lbs	  	VWR	  	

  
 Exhibit D - Page 1 of 1

  
 EXHIBIT E 

FORM OF LETTER OF CREDIT 
  

					
		 	FOR INTERNAL IDENTIFICATION PURPOSES ONLY	  	
		 	Our No. __________ Other __________	  	
		 	Applicant ___________________________	  	

  

	TO:	Metropolitan Life Insurance Company 

  

	 	[Address] 

  

	 	Attention: Director, EIM 

 IRREVOCABLE LETTER OF CREDIT NO.
___________ 
 We hereby establish this irrevocable Letter of Credit in favor of the aforesaid addressee (“Beneficiary”) for
drawings up to United States $__________ effective immediately. This Letter of Credit is issued, presentable and payable at our office at [issuing bank’s address in City specified by Landlord] and expires with our close of business on
___________, 20__. 
 The term “Beneficiary” includes any successor by operation of law of the named Beneficiary including,
without limitation, any liquidator, rehabilitator, receiver or conservator. 
 We hereby undertake to promptly honor your sight draft(s)
drawn on us, indicating our Credit No. ________, for all or any part of this Credit if presented at our office specified in paragraph one on or before the expiry date or any automatically extended expiry date. 

Except as expressly stated herein, this undertaking is not subject to any agreement, condition or qualification. The obligation of [issuing
bank] under this Letter of Credit is the individual obligation of [issuing bank], and is in no way contingent upon reimbursement with respect thereto. 
 It is a condition of this Letter of Credit that it is deemed to be automatically extended without amendment for one year from the expiry date hereof, or any future expiration date, unless at least thirty
(30) days prior to an expiration date we notify you by registered mail that we elect not to consider this Letter of Credit renewed for any such additional period. 
 This Letter of Credit is transferable by the Beneficiary and by any successive transferees at no charge or cost to Beneficiary or any transferee. Transfers of this Letter of Credit are subject to receipt of
Beneficiary’s (and subsequently, transferee’s) instructions in the form attached hereto as Schedule 1 accompanied by the original Letter of Credit and amendments(s) if any. 

This Letter of Credit is subject to and governed by the Laws of the State of New York and the 1993 revision of the Uniform Customs and Practice for
Documentary Credits of the International Chamber of Commerce (Publication 500) and, in the event of any conflict, the Laws of the State of New York will control. If this Credit expires during an interruption of business as described in article 17 of
said Publication 500, the bank hereby specifically agrees to effect payment if this Credit is drawn against within 30 days after the resumption of business. 

 

	
	Very truly yours,
	
	  
	         [issuing bank]

  
 Exhibit E - Page 1 of 2

  
 Schedule 1 to Letter of Credit

 [Bank – then current issuer of Letter of Credit] 
 c/o _________________________ 
 ____________________________ 
 ____________________________ 
 Attention:____________________ 

Re: Irrevocable Letter of Credit No. ________________ 

Ladies & Gentlemen: 
 The undersigned
acknowledges receipt of your advice No. _________________ of a credit issued in our favor, the terms of which are satisfactory. We now irrevocably transfer the said credit and all amendments and extensions thereof, if any, to: 

_________________________ 
 [Name of
Transferee] 
  
 _________________________ 

[Address] 
 You are to inform the
transferee of this transfer and such transferee shall have sole rights as beneficiary under the credit, including any amendments, extension or increases thereof, without notice to or further assent from us. 

This transfer is at no charge or cost to Beneficiary or the transferee. 

 

			
	Yours very truly,
	
	Beneficiary
		
	By:	 	 
		 	

  
 Acknowledged and agreed by Bank [then current
issuer of Letter of Credit]: 

_______________________                     
                
 (Bank – then current issuer of Letter of
Credit) 

  
 Exhibit E - Page 2 of 2

  
 RIDER 1 

COMMENCEMENT DATE AGREEMENT 
 Metropolitan Life
Insurance Company, a New York corporation (“Landlord”), and AcelRx Pharmaceuticals, Inc., a Delaware corporation (“Tenant”), have entered into a certain Lease dated Jan. 2, 2007 ____ (the “Lease”). 

WHEREAS, Landlord and Tenant wish to confirm and memorialize the Commencement Date and Expiration Date of the Lease as provided for in Section 2.02(b) of the
Lease; 
 NOW, THEREFORE, in consideration of the foregoing and the mutual covenants contained herein and in the Lease, Landlord and Tenant agree as
follows: 
  

	 	1.	Unless otherwise defined herein, all capitalized terms shall have the same meaning ascribed to them in the Lease. 

 

	 	2.	The Commencement Date (as defined in the Lease) of the Lease is April 9, 2007. 

 

	 	3.	The Expiration Date (as defined in the Lease) of the Lease is April 8, 2012. 

 

	 	4.	Tenant hereby confirms the following: 

  (a)       That it has accepted possession of the premises pursuant to the terms of the Lease; 

  (b)       That the Landlord Work, if any, is Substantially Complete; and 

  (c)       That the Lease is in full force and effect. 

5.       Except as expressly modified hereby, all terms and provisions of the Lease are hereby ratified and confirmed
and shall remain in full force and effect and binding on the parties hereto. 
 6.       The Lease and this
Commencement Date Agreement contain all of the terms, covenants, conditions and agreements between the Landlord and the Tenant relating to the subject matter herein. No prior other agreements or understandings pertaining to such matters are valid or
of any force and effect. 
 IN WITNESS WHEREOF, Landlord and Tenant have executed this Commencement Date Agreement and such execution and
delivery have been duly authorized. 
  

					
	TENANT:	  	 	  	LANDLORD:
			
	 AcelRx Pharmaceuticals, Inc.,
	  		  	Metropolitan Life Insurance Company,
	 a Delaware corporation
	  		  	a New York corporation
			
	 By /s/ Thomas A. Schreck
	  		  	By /s/ Joel R.
Redman                        
			
		  		  	
	 Thomas A. Schreck

        Print name
	  		  	 Joel R. Redman

    Print name

			
	 Its
Chairman                                       
 
	  		  	Its Assistant Vice-President                
	 (Chairman of Board, President or Vice President)
	  		  	
			
	 By /s/ Carter
King                                         
   
	  		  	
			
	Carter King	  		  	
			
	Print name	  		  	
			
	
Its Treasurer                      
                  
	  		  	
	 (Secretary, Assistant Secretary, CFO or Assistant Treasurer)

  
 Rider 1 - Page 1 of 1

  
 RIDER 2 

ADDITIONAL PROVISIONS 
 This Rider 2
(“Rider”) is attached to and a part of a certain Lease by Metropolitan Life Insurance Company, a New York corporation, as Landlord, and AcelRx Pharmaceuticals, Inc., a Delaware corporation, as Tenant, for the Premises as described therein
(the “Lease”). 
 SECTION 1.       DEFINED TERMS; FORCE AND EFFECT 

Capitalized terms used in this Rider shall have the same meanings set forth in the Lease except as otherwise specified herein and except for terms capitalized in
the ordinary course of punctuation. This Rider forms a part of the Lease. Should any inconsistency arise between this Rider and any other provision of the Lease as to the specific matters which are the subject of this Rider, the terms and conditions
of this Rider shall control. 
 SECTION 2.       CONDITION OF PREMISES; DELIVERY; CONSTRUCTION PERIOD; COMMENCEMENT DATE;
TERM 
 2.1.       Projected Delivery Date; Delivery Date; Commencement Date: Tenant’s Obligations
During Construction Period; Term. 
 (a)       Landlord shall tender to Tenant possession of the
Premises in the condition specified in the Workletter no later than one (1) business day after execution of this Lease by both Tenant and Landlord (the “Projected Delivery Date”). On the date Landlord actually tenders to Tenant
possession of the Premises (the “Delivery Date”), all the terms and conditions of the Lease shall apply, and Tenant shall observe and perform all terms and conditions of the Lease, including all that are specified to apply during the Term
(for example only, Tenant’s insurance and indemnification obligations), except that during the period (the “Construction Period”) from the Delivery Date until the Commencement Date (defined below), in recognition of Tenant’s
construction and installations in, and preparation of, the Premises for the use and occupancy permitted by this Lease: (i) Tenant shall not be obligated to pay Monthly Base Rent, Rent Adjustment Deposits or Rent Adjustments; and
(ii) Landlord shall not be obligated to provide services or utilities except if and to the extent expressly provided in Section 4 of the Workletter. The Term of this Lease shall be as shown in Section 1.01(5) of the Basic Lease
Provisions and the Commencement Date of the Term shall be the date which is the earlier to occur of (i) the date Tenant commences its business operations in the Premises, or (ii) ninety (90) days after the Delivery Date. 

(b)       Upon request by Landlord, Tenant and Landlord shall enter into an agreement (the form of which is attached
to this Lease as Rider 1) confirming the Commencement Date and the Expiration Date. If Tenant fails to enter into such agreement, then the Commencement Date and the Expiration Date shall be the dates designated by Landlord in such agreement.

 2.2       Failure to Deliver Possession. If Landlord shall be unable to give possession of the
Premises on the Projected Delivery Date by reason of the following: (i) the holding over or retention of possession of any tenant, tenants or occupants, or (ii) the Landlord Work, if any, is not Substantially Complete, or (iii) for
any other reason, then Landlord shall not be subject to any liability for the failure to give possession on said date so long as Landlord has used and continues to use reasonable efforts to deliver possession to Tenant as soon as possible. Under
such circumstances, by operation of Section 2.1 above and/or the definition of the Commencement Date, the Delivery Date and Commencement Date are automatically adjusted and determined in relation to the date Landlord actually tenders possession
of the Premises to Tenant. No such failure to deliver possession on the originally scheduled Projected Delivery Date shall affect the validity of this Lease or the obligations of the Tenant hereunder. 

SECTION 3.       MONUMENT SIGNAGE. 
 3.1       Grant of Right. Notwithstanding any provision of Section 6.06 of the Lease to the contrary, so long as Tenant is in continuous operation at and occupancy of at
least fifty percent (50%) of the entire Premises, Tenant shall have the right, to place Tenant identification on one line of one existing, exterior monument sign for the Building, subject to the terms and conditions of this Section
(“Exterior Sign Right”). 
 3.2       General Conditions & Requirements. The size,
type, style, materials, color, method of installation and exact location of the sign, and the contractor for and all work in connection with the sign, contemplated by this Section shall (i) be subject to Tenant’s compliance with all
applicable laws, regulations and ordinances and with any covenants, conditions and restrictions of record which affect the Property; (ii) be subject to Tenant’s compliance with all requirements of Landlord’s current Project signage
criteria at the time of installation; (iii) be consistent with the design of the Building and the Project; (iv) be further subject to Landlord’s prior written consent. Tenant shall, at its sole cost and expense, procure, install,
maintain and remove such sign. 
 3.3       Removal & Restoration. Upon the expiration or
termination of the Exterior Sign Right, but in no event later than the expiration of the Term or earlier termination of the Lease, Tenant shall, at its sole cost and expense, remove such sign and shall repair and restore the area in which the sign
was located to its condition prior to installation of such sign. 
 3.4       Right Personal. The
Exterior Sign Right under this Section is personal to AcelRx Pharmaceuticals, Inc., a Delaware corporation, and may not be used by, and shall not be transferable or assignable (voluntarily or involuntarily) to any person or entity other than an
assignee of the Lease which has satisfied the requirements of Article Ten of the Lease. 

  
 Rider 2 - Page 1 of 2Loan and Security Agreement - Pinnacle Ventures, L.L.C.

  
 Exhibit 10.9 

EXECUTION COPY 
 LOAN AND SECURITY
AGREEMENT 
 This LOAN AND SECURITY AGREEMENT, dated as of September 16, 2008 (this “Loan
Agreement”), is entered by and between ACELRX PHARMACEUTICALS, INC., a Delaware corporation (“Borrower”); and PINNACLE VENTURES, L.L.C. as agent (“Agent”) for the
lenders identified on Schedule 1 hereto (such lenders, together with their respective successors and assigns are referred to hereinafter each individually as a “Lender” and collectively as the
“Lenders”), and the Lenders. Capitalized terms used and not otherwise defined in this Loan Agreement shall have the respective meanings given to such terms in Article 10. 

In consideration of the covenants, conditions and agreements set forth herein and intending to be legally bound, the parties agree as follows:

 Article 1.    THE LOANS. 

Section 1.01    Commitment.  Subject to the terms and conditions of this Loan Agreement, Lenders agree to
advance to Borrower (the “Advances”): (i) from time to time on or prior to December 31, 2008, one or more term loans in an aggregate principal amount of Six Million Dollars ($6,000,000), and (ii) from time to
time on or prior to June 30, 2009 (the “Funding Termination Date”), one or more term loans in an aggregate principal amount of up to Six Million Dollars ($6,000,000). Advances shall be made not more often than monthly in
amounts of no less than Five Hundred Thousand Dollars ($500,000) provided that if there is less than Five Hundred Thousand Dollars available to be borrowed under this Section 1.01, then such Advance shall not be less than the available
principal amount to be borrowed. Borrower may prepay Advances in accordance with Section 1.02(d). 
 Section
1.02    Interest and Payments. 
  

	 	(a)	Interest.  Borrower shall pay interest in advance on the unpaid principal amount of each Advance from the date of such Advance until such Advance is paid in
full, at a per annum rate of interest equal to eight and one-half percent (8.50%), based upon a year of 360 days and actual days elapsed. If Borrower pays interest on such Advance which is determined to be in excess of the then legal maximum rate,
then that portion of each interest payment representing an amount in excess of the then legal maximum rate shall be deemed a payment of principal and applied against the principal of the Advance. 

 

	 	(b)	Payments of Principal and Interest.  For each Advance, Borrower shall make six (6) equal monthly payments of interest only (payable in advance) on the first
Business Day of each month after the Funding Date (or, if the Funding Date occurs on the first Business Day of a month, on such Funding Date) (each a “Payment Date”). Thereafter, Borrower shall make thirty (30) equal
payments of principal and interest (payable in advance) on the first Business Day of each month (each a “Payment Date”) until the Advance is paid in full. The amount of each such payment shall be sufficient to fully amortize
the principal and interest due on the applicable Advance over such thirty (30) month period. 

  

	 	(c)	Interim Interest Payment.  For each Advance, unless the Funding Date is a Payment Date, Borrower shall make an advance payment of interest at the otherwise
applicable rate referred to in Section 1.02(a) on the Funding Date for the period from the Funding Date to the first Payment Date. 

  

	 	(d)	Final Payment.  On the date on which the last payment is due under Section 1.02(b) with respect to each Advance, Borrower shall pay to Agent, in addition to
any remaining unpaid principal and accrued interest and all other amounts previously due with respect to such Advance, an amount equal to five percent (5.0%) of the original principal amount of such Advance (the “Final
Payment”). 

  

	 	(e)	Prepayment.  Upon five (5) Business Days’ prior written notice to Agent, Borrower may, at its option, at any time, prepay the Advances, in whole or in
part in an amount of a least $1,000,000 of principal, in an amount equal to the outstanding principal amounts of the portion of the Advances prepaid, plus accrued and unpaid interest thereon through and including the date of such prepayment, plus
the Final Payment, plus any other amounts then due to Lenders, together with all scheduled but unpaid interest payments with respect to the portion prepaid. 

 Section 1.03    Use of Proceeds; the Advances and the Notes; Disbursement. 
  

	 	(a)	Use of Proceeds.  The proceeds of the Advances shall be used for general corporate purposes. 

 

	 	(b)	The Advances and the Notes.  The obligation of Borrower to repay the aggregate unpaid principal amount of and interest on each Advance shall be evidenced by a
Note setting forth the principal amount of such Advance and the payments due. Agent shall keep a record of the payments made under each Note on its books which records shall be prima facie evidence of the amounts paid under the Notes absent manifest
error. Any failure by Agent to obtain or retain such a Note shall not limit or otherwise affect the obligations of Borrower to pay amounts due hereunder with respect to an Advance. 

 

	 	(c)	Notice and Disbursement.  Whenever Borrower desires Lenders to make an Advance, Borrower shall notify Agent in writing at least fifteen
(15) Business Days in advance of the desired Funding Date, which notice shall be irrevocable. Lenders’ obligation to make Advances shall be subject to the satisfaction of the conditions set forth in Section 3.01(b). Lenders
shall have the right to request that Borrower furnish Lenders with such additional information with respect to the Advance as Lenders shall reasonably request. Subject to the satisfaction of the conditions set forth in this
Loan Agreement, each Lender shall disburse its pro rata portion of each Advance to the account of Borrower as specified in Section 9.06. 

 Section 1.04    Other Payment Terms. 
  

	 	(a)	Place and Manner.  All regularly scheduled payments due to the Lenders shall be effected by automatic debit of the appropriate funds from Borrower’s Primary
Operating Account. Borrower shall make all other payments due to the Lenders in lawful money of the United States, in immediately available funds, at the address for payments specified in Section 9.06. 

 

	 	(b)	Date.  Whenever any payment due hereunder shall fall due on a day other than a Business Day, such payment shall be made on the next succeeding Business Day, and
such extension of time shall be included in the computation of interest or fees, as the case may be. 

  

	 	(c)	Default Rate.  If any amounts required to be paid by Borrower under this Loan Agreement or the other Transaction Documents (including principal or interest
payable on the Advance, any fees or other amounts) remain unpaid after such amounts are due, Borrower shall pay interest on the aggregate, outstanding principal balance hereunder from the date due until such past due amounts are paid in full, at a
per annum rate equal to the Default Rate. All computations of such interest shall be based on a year of 360 days and actual days elapsed. 

  

	 	(d)	 Commitment Fee.  Agent has received a commitment fee from Borrower in the amount of $25,000 (the “Commitment Fee”). The
Commitment Fee is fully earned and will be retained by Agent; 

  
 -2- 

	 	 
provided, however, that the Commitment Fee will be returned to Borrower if the Advances and the Transaction Documents are not approved by Lenders’ investment committee.

  

	 	(e)	Legal Costs.  Borrower shall reimburse Lender for Lender’s reasonable legal costs and expenses incurred in preparing and negotiating the Transaction
Documents. 

 Article 2.    CREATION OF SECURITY INTEREST. 

Section 2.01    Grant of Security Interest.  Borrower grants and pledges to Agent on behalf of all Lenders a
continuing security interest in all presently existing and hereafter acquired or arising Collateral in order to secure prompt payment of any and all Obligations and in order to secure prompt performance by Borrower of each of its covenants and
duties under the Transaction Documents. Such security interest constitutes a valid, first priority security interest in the presently existing Collateral, and will constitute a valid, first priority security interest in Collateral acquired after the
date hereof. Notwithstanding termination of this Loan Agreement, Agent’s Lien on the Collateral shall remain in effect for so long as any Obligations are outstanding. 
 Section 2.02    Liabilities Unconditional.  Borrower is and shall remain absolutely and unconditionally liable for the performance of its obligations under the
Transaction Documents, including without limitation any deficiency by reason of the failure of the Collateral to satisfy all amounts due to Agent or the Lenders under any Transaction Document. 

Article 3.    CLOSING. 
 Section
3.01    Conditions Precedent.  The obligation of Lenders to fund an Advance shall be subject to the following conditions precedent: 

 

	 	(a)	Conditions to Closing.  Agent shall have received in connection with the Closing in form and substance satisfactory to Agent: 

 

	 	(i)	This Loan Agreement, duly executed by Borrower; 

  

	 	(ii)	Copies, certified by the Secretary or Assistant Secretary of Borrower, of: (A) the Certificate of Incorporation and Bylaws of Borrower (as amended to the date of this Loan
Agreement), (B) the resolutions adopted by Borrower’s board of directors authorizing the transaction and the documents being executed in connection therewith, and (C) the incumbency of the officers executing this Loan Agreement and
the other Transaction Documents on behalf of Borrower. 

  

	 	(iii)	Good Standing Certificate(s) (including tax status if available) with respect to Borrower from Borrower’s state of incorporation and principal place of business, if
different, (each) as of a date acceptable to Agent. 

  

	 	(iv)	Evidence of the insurance coverage required by Section 5.06 of this Loan Agreement. 

 

	 	(v)	All necessary consents of shareholders and other third parties with respect to the subject matter of the Loan Agreement and the other documents being executed in connection
therewith. 

  

	 	(vi)	A Warrant Purchase Agreement in the form provided by Agent and agreed to by Borrower, duly executed by Borrower. 

 

	 	(vii)	The Warrants to be issued to the designees of the Lenders in forms provided by Agent and agreed to by Borrower, duly executed by Borrower. 

 

	 	(viii)	A Management Rights Agreement in the form provided by Agent and agreed to by Borrower, duly executed by Borrower. 

  
 -3- 

  

	 	(ix)	Agreements sufficient to perfect a security interest in Borrower’s deposit accounts and securities accounts executed by each applicable bank or other financial institution,
in forms reasonably acceptable to Agent. 

  

	 	(x)	A legal opinion of counsel to Borrower in form and substance reasonably satisfactory to Agent. 

 

	 	(b)	Conditions to Funding of Each Advance.  Prior to the funding of each Advance, the following conditions with respect to such Advance shall have been satisfied by
Borrower or waived by Agent: 

  

	 	(i)	Borrower shall have executed and delivered a Note in the form of Exhibit A prepared by Agent setting forth the terms of the Advance. 

 

	 	(ii)	No Event of Default or Default shall have occurred and be continuing. 

  

	 	(iii)	In Agent’s reasonable discretion, no event or condition shall exist that has had or could be reasonably expected to have a Material Adverse Effect. 

 

	 	(iv)	The representations and warranties contained in this Loan Agreement and the other Transaction Documents to which Borrower is a party shall be true and correct in all material
respects as if made on the date of funding of the Advance and the items listed on any schedule shall be reasonably acceptable to Agent, except to the extent such representations and warranties expressly refer to an earlier date, in which case they
shall be true and correct in all material respects as of such earlier date. 

  

	 	(v)	Each of the Transaction Documents shall be in full force and effect. 

  

	 	(vi)	Borrower shall have provided to Agent a Landlord Waiver in the form of Exhibit C hereto or otherwise in form and substance satisfactory to Agent, from each owner of record
of real property at which items of Collateral will be located, setting forth the rights of Agent with respect to such items of Collateral. 

  

	 	(vii)	Borrower shall have provided to Agent such documents, instruments and agreements, including financing statements or amendments to financing statements, as Agent shall reasonably
request to evidence the perfection and priority of the security interests granted to Agent. 

 Article
4.    REPRESENTATIONS AND WARRANTIES OF BORROWER. 
 Borrower represents and warrants to Agent that: 

Section 4.01    Due Incorporation, Qualification, etc.  Each of Borrower and its Subsidiaries (i) is a
corporation duly organized, validly existing and in good standing under the laws of its state of incorporation; (ii) has the power and authority to own, lease and operate its properties and carry on its business as now conducted; and
(iii) is duly qualified, licensed to do business and in good standing as a foreign corporation in each jurisdiction where the failure to be so qualified or licensed could reasonably be expected to have a Material Adverse Effect. 

Section 4.02    Authority.  The execution, delivery and performance by Borrower of each Transaction Document to
be executed by Borrower and the consummation of the transactions contemplated thereby (i) are within the power of Borrower and (ii) have been duly authorized by all necessary actions on the part of Borrower. 

Section 4.03    Enforceability.  Each Transaction Document executed, or to be executed, by Borrower has been, or
will be, duly executed and delivered by Borrower and constitutes, or will constitute, a legal, valid and binding obligation of Borrower, enforceable against Borrower in accordance with its terms, except as limited

  
 -4- 

 
by bankruptcy, insolvency or other similar laws of general application relating to or affecting the enforcement of creditors’ rights generally and general principles of equity. 

Section 4.04    Non-Contravention.  The execution and delivery by Borrower of the Transaction Documents executed
by Borrower and the performance and consummation of the transactions contemplated thereby do not and will not (i) violate any Requirement of Law described in clause (i) of the definition of Requirement of Law or violate and other material
Requirement of Law applicable to Borrower; (ii) violate any provision of, or result in the breach or the acceleration of, or entitle any other Person to accelerate (whether after the giving of notice or lapse of time or both), any material
Contractual Obligation of Borrower; or (iii) result in the creation or imposition of any Lien upon any property, asset or revenue of Borrower (except such Liens as may be created in favor of Agent pursuant to this Loan Agreement or the other
Transaction Documents). 
 Section 4.05    Approvals.  No consent, approval, order or authorization of,
or registration, declaration or filing with, any Governmental Authority or other Person (including, without limitation, the shareholders of any Person) is required in connection with the execution and delivery of the Transaction Documents executed
by Borrower and the performance and consummation of the transactions contemplated thereby. 
 Section 4.06    No
Violation or Default.  None of Borrower or Borrower’s Subsidiaries is in violation of or in default with respect to (i) any Requirement of Law; or (ii) any Contractual Obligation (nor is there any waiver in effect
which, if not in effect, would result in such a violation or default), where, in each case, such violation or default, individually, or together with all such violations or defaults, could reasonably be expected to have a Material Adverse Effect.
Without limiting the generality of the foregoing, neither Borrower nor Borrower’s Subsidiaries, to its knowledge (A) has violated any Environmental Laws, (B) has any liability under any Environmental Laws or (C) has received
notice or other communication of an investigation or is under investigation by any Governmental Authority having authority to enforce Environmental Laws, where such violation, liability or investigation could reasonably be expected to have a
Material Adverse Effect. No Event of Default or Default has occurred and is continuing. 
 Section
4.07    Litigation.  No actions (including, without limitation, derivative actions), suits, proceedings or investigations are pending or, to the knowledge of Borrower, threatened against Borrower or
Borrower’s Subsidiaries at law or in equity in any court or before any other Governmental Authority which if adversely determined (i) could reasonably be expected (alone or in the aggregate) to have a Material Adverse Effect or
(ii) seeks to enjoin, either directly or indirectly, the execution, delivery or performance by Borrower of the Transaction Documents or the transactions contemplated thereby. 
 Section 4.08    Title.  Borrower has good and marketable title to all Collateral, free and clear of all Liens, other than Permitted Liens. Borrower has no other
deposit accounts or securities accounts, other than the deposit accounts and securities accounts described in Schedule 2. Except as described in Schedule 2, the Collateral is not in the possession of any third party bailee (such as at
a warehouse). All Inventory is in all material respects of good and marketable quality, free from material defects. 
 Section
4.09    Financial Statements.  The Financial Statements of Borrower which have been delivered to Agent (i) are in accordance with the books and records of Borrower and its Subsidiaries, which have
been maintained in accordance with good business practice; (ii) have been prepared in conformity with generally accepted accounting principles (except in the case of unaudited financial statements for the absence of footnotes and year-end
adjustments); and (iii) fairly present in all material respects the consolidated financial position of Borrower as of the dates presented therein and the results of operations, changes in financial positions or cash flows, as the case may be,
for the periods presented therein. As of the date hereof, none of Borrower or any of Borrower’s Subsidiaries has any contingent obligations, liability for taxes or other outstanding obligations which are material in the aggregate, except as
disclosed in the most recent audited Financial Statements (including the notes thereto) furnished by Borrower to Agent prior to the date hereof. 

Section 4.10    Taxes.  Each of Borrower and its Subsidiaries has filed or caused to be filed all tax returns
that are required to be filed by it except where the failure to do so could not reasonably be expected to have a 

  
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Material Adverse Effect. Borrower and Borrower’s Subsidiaries have paid, or made provision for the payment of, all Taxes which have or may have become due pursuant to said returns or
otherwise, except such Taxes, if any, which are being contested in good faith and as to which adequate reserves (determined in accordance with generally accepted accounting principles) have been provided or which could not reasonably be expected to
have a Material Adverse Effect if unpaid. 
 Section 4.11    Catastrophic Events; Labor Disputes.  Neither
Borrower nor Borrower’s Subsidiaries and none of their properties is or has been affected by any fire, explosion, accident, strike, lockout or other labor dispute, drought, storm, hail, earthquake, embargo, act of God or other casualty that
could reasonably be expected to have a Material Adverse Effect. There are no disputes presently subject to grievance procedure, arbitration or litigation under any of the collective bargaining agreements, employment contracts or employee welfare or
incentive plans to which Borrower or Borrower’s Subsidiaries is a party, and there are no strikes, lockouts, work stoppages or slowdowns, or, to the best knowledge of Borrower, jurisdictional disputes or organizing activity occurring or
threatened which could reasonably be expected to have a Material Adverse Effect. 
 Section 4.12    No Material Adverse
Effect.  No event has occurred and no condition exists (excluding general economic conditions) which could reasonably be expected to have a Material Adverse Effect. 
 Section 4.13    First Priority.  Assuming the timely filing of financing statements covering the Collateral, the security interest granted hereby constitutes a
first priority security interest in and Lien on all of the Collateral, subject only to Permitted Liens. 
 Section
4.14    Principal Place of Business.  Borrower is incorporated in the jurisdiction stated in the first sentence of this Loan Agreement, and the office where Borrower will keep all records and files
regarding the Collateral is set forth in Section 9.07. Except as disclosed on Schedule 2, Borrower has not done business under any name other than that specified on the signature page hereof. All Borrower’s Inventory and
Equipment is located only at the locations set forth in Section 9.07 or on Schedule 2 or at such other locations as are permitted under Section 5.12. 
 Section 4.15    Intellectual Property.  Borrower is the sole owner of the Intellectual Property, except for non-exclusive licenses granted by Borrower to its
customers in the ordinary course of business. No part of the Intellectual Property has been judged invalid or unenforceable, in whole or in part, and, to Borrower’s knowledge, no claim has been made that any part of the Intellectual Property
violates the rights of any third party. 
 Section 4.16    Investments.  Borrower does not own any
Investments in any Person, except for Permitted Investments. 
 Article 5.    COVENANTS OF BORROWER. 

While any Obligations or unfunded Commitments remain outstanding: 

Section 5.01    Financial Statements.  Borrower shall provide to Agent the financial statements specified in
this Section 5.01, prepared in accordance with generally accepted accounting principles, consistently applied (except, in the case of unaudited financial statements, for the absence of footnotes and normal year-end adjustments);
provided, however, that after the effective date of the initial registration statement covering a public offering of Borrower’s securities, Borrower shall only be required to deliver those financial statements required to be filed
by the Securities and Exchange Commission, to be provided as soon as practicable and no less frequently than quarterly. 
  

	 	(a)	 As soon as practicable (and in any event within thirty (30) days after the end of each month), an unaudited balance sheet as of the end of such month and
unaudited statements of income or loss, retained earnings or deficit, cash flows and capital structure of Borrower for such month, certified by 

  
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Borrower’s Chief Executive Officer or Chief Financial Officer to fairly present in all material respects the data reflected therein. 

 

	 	(b)	As soon as practicable (and in any event within one hundred eighty (180) days after the end of each fiscal year), audited balance sheets as of the end of such year
(consolidated if applicable), and related statements of income or loss, retained earnings or deficit, cash flows and capital structure of Borrower for such year, setting forth in comparative form the corresponding figures for the preceding fiscal
year, and accompanied by an audit report and opinion of the independent certified public accountants of recognized national standing selected by Borrower. 

 Section 5.02    Other Information.  Borrower shall promptly provide to Agent: (a) copies of all board packages delivered to its board of directors in
connection with board meetings or otherwise, (b) notice of all actions, suits and proceedings before any court or governmental department, commission, board, bureau, agency or instrumentality, domestic or foreign, which suits or proceedings if
decided adversely to Borrower could reasonably be expected to result in costs or damages to Borrower of One Hundred Thousand Dollars ($100,000) or more, (c) notice of any Default, Event of Default, Event of Loss, or any matter which has
resulted or may reasonably expected to result in a Material Adverse Effect, and (d) any additional information (including but not limited to tax returns, income statements, balance sheets, and names of principal creditors) as Agent shall
reasonably request which is necessary to evaluate Borrower’s continuing financial obligations. 
 Section
5.03    Corporate Identity.  Borrower shall notify Agent in writing thirty (30) days prior to any change in Borrower’s principal place of business or chief executive office and any change of
Borrower’s name, identity or corporate structure. 
 Section 5.04    Reserved. 

Section 5.05    Authorization for Automated Clearinghouse Funds Transfer.  Borrower shall (i) authorize
Agent to initiate debit entries to Borrower’s account specified in Section 9.06 (“Borrower’s Primary Operating Account”) through Automated Clearinghouse (“ACH”) transfers, in order to
satisfy regularly scheduled payments of principal, interest and fees; (ii) provide Agent at least thirty (30) days notice of any change in Borrower’s Primary Operating Account; and (iii) grant Agent any additional authorizations
necessary to begin ACH debits from a new account which becomes Borrower’s Primary Operating Account. 
 Section
5.06    Insurance.  Borrower shall, at its own expense, maintain the following types of insurance, with companies with an A-5 Best rating or better, in amounts acceptable to Agent: 

 

	 	(a)	Property. Property insurance against loss or damage to the Collateral. The deductible shall not exceed $25,000. The policy shall name Agent as sole loss payee with respect
to the Collateral, shall not be invalidated by any action of or breach of warranty by Borrower of any provision thereof and shall waive subrogation against Agent. 

 

	 	(b)	General Liability Insurance. Commercial general liability insurance (including contractual liability, products liability and completed operations coverages) reasonably
satisfactory to Agent. The limit of liability shall be at least $2,000,000 per occurrence. The policy shall be without deductible, except for products liability coverage which may have a deductible up to $25,000. The policy(ies) shall name Agent as
additional insured in the full amount of Borrower’s liability coverage limits (or the coverage limits of any successor to Borrower or such successor’s parent which is providing coverage), be primary and without contribution as respects any
insurance carried by Agent and contain cross liability and severability of interest clauses. 

  

	 	(c)	Other Insurance. Such other insurance against risks of loss and with terms as shall be reasonably required by Agent. 

  
 -7- 

  
 All policies of insurance shall provide that
Agent shall be given thirty (30) days notice of cancellation of coverage. This notice provision shall be without qualification. On or prior to the first Funding Date and prior to each policy renewal, Borrower shall furnish to Agent,
certificates of insurance or other evidence satisfactory to Agent that insurance complying with all of the above requirements is in effect. 
 Section
5.07    Taxes and Other Liabilities.  Borrower shall pay all Indebtedness when due; pay all Taxes and other governmental or regulator assessments before delinquency or before any penalty attaches
thereto, except as may be contested in good faith by the appropriate procedures and for which Borrower shall maintain appropriate reserves; and timely file all required tax returns. 
 Section 5.08    Title.  Borrower shall promptly notify Agent in writing of any event which materially affects the value of the Collateral, the ability of Borrower
or Agent to dispose of the Collateral, or the rights or remedies of Agent in relation thereto, including, but not limited to, the levy of any legal process against the Collateral. Upon request by Agent, Borrower shall deliver to Agent any and all
evidence of ownership of, and certificates of title to, any and all of the Equipment. 
 Section 5.09    Further
Identification of Collateral.  Borrower shall promptly advise Agent of any material change in the composition of the Collateral, and shall furnish to Agent from time to time such statements and schedules further identifying and
describing the Collateral, and such other reports in connection with the Collateral as Agent may reasonably request, all in reasonable detail. 

Section 5.10    Good Repair.  Borrower shall keep and maintain all Collateral in good operating condition and
repair, subject to ordinary wear and tear, make all necessary repairs thereto and replacement of parts thereof so that the value and operating efficiency thereof shall at all times be maintained and preserved in all material respects; and Borrower
shall keep books and records with respect to the Collateral, including maintenance records, which are complete and accurate in all material respects. 

Section 5.11    Loss; Damage; Destruction and Seizure. 

 

	 	(a)	If while payment Obligations are outstanding any item of Collateral is lost, stolen, destroyed, damaged beyond repair or seized by a Governmental Authority (an “Event
of Loss”), then, at Borrower’s option, either (i) Agent shall receive from the proceeds of insurance maintained pursuant to Section 5.06, from any award paid by the seizing Governmental Authority or, to the extent not
received from the proceeds of insurance or award or both, from Borrower, on or before the next scheduled Payment Date succeeding such Event of Loss, an amount equal to the replacement value of the item of Collateral subject to the Event of Loss
which shall be held as additional Collateral for the Advance, or (ii) if no Event of Default has occurred and is continuing, Borrower may use any such proceeds to purchase an item of Collateral to replace the item of Collateral which was
subject to the Event of Loss and such replacement Collateral shall become part of the Collateral. On the date of receipt by Agent of the amount specified hereinabove with respect to each such item of Collateral subject to an Event of Loss, the
provisions of this Loan Agreement shall terminate as to such Collateral. Pending Borrower’s election of the options set forth above, any proceeds of insurance maintained by Borrower with respect to the Collateral pursuant to Section 5.06
and received by Borrower shall be paid to Agent promptly upon their receipt by Borrower. If any proceeds of insurance or awards received from Governmental Authorities are in excess of the amount owed under this Section 5.11(a), Agent shall
promptly remit to Borrower the amount in excess of the amount to be held by Agent. 

  

	 	(b)	 So long as no Event of Default has occurred and is continuing, any proceeds of insurance maintained pursuant to Section 5.06 received by Agent or Borrower
with respect to an item of Collateral the repair of which is practicable shall, at the election of Borrower, be applied either to the repair or replacement of such Collateral or, upon Agent’s receipt of evidence of the repair or replacement of
the Collateral reasonably satisfactory to Agent, to the reimbursement of Borrower for the cost of such repair or replacement. All replacement parts and equipment acquired by Borrower in replacement of

  
 -8- 

	 	 
Collateral pursuant to this Section 5.11 shall immediately become part of the Collateral upon acquisition by Borrower. Borrower shall take such actions and provide such documentation as may
be reasonably requested by Agent to protect and preserve Agent’s first priority security interest and otherwise to avoid any impairment of Agent’s rights under the Transaction Documents, in connection with such repair or replacement.

 Section 5.12    Collateral Control.  Borrower shall not (i) terminate, waive
or release any material right with respect to any Collateral, or (ii) remove any items of Collateral from Borrower’s facility located at the address specified in Section 9.07, the locations specified on Schedule 2, or such
other address agreed to in writing by Lender. 
 Section 5.13    Liens; No Disposition of
Collateral.  Borrower shall not (i) in any way hypothecate or create or permit to exist any Lien with respect to any of its or its Subsidiaries’ property, except for Permitted Liens, (ii) permit the inclusion in any
contract to which it or a Subsidiary becomes a party of any provisions that could restrict or invalidate the creation of a security interest in any of Borrower’s or such Subsidiary’s property, or (iii) sell, transfer, assign, pledge,
collaterally assign, exchange, or otherwise dispose of (collectively, a “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, other than Transfers: (A) of Inventory in the ordinary
course of business, (B) of non-exclusive licenses and similar arrangements for the manufacture, sale or use of the property of Borrower or its Subsidiaries in the ordinary course of business, (C) of exclusive licenses and similar
arrangements for the use, manufacture or sale of the property of Borrower in a specific field or geography, or (D) worn-out or obsolete Equipment. 

Section 5.14    Mergers and Acquisitions.  Without the prior written consent of Agent, Borrower shall not be
acquired by any “person” (as such term is used in Section 13(d) and 14(d) of the Securities Exchange Act of 1934), whether by merger or consolidation, or through a transaction or series of transactions pursuant to which the holders of
Borrower’s voting Equity Securities do not hold at least 50% of the voting power of Borrower or any resulting Person after such transaction or transactions, or through the sale of all or substantially all of its assets, unless (i) the
Obligations are assumed or guarantied by a Person which is the ultimate parent entity (the “Acquirer”) of the acquiring Person and (ii) the Acquirer is a creditworthy entity (as determined by Agent in its reasonable
discretion). 
 Section 5.15    Distributions.  Prior to the effective date of the initial registration
statement covering a public offering of Borrower’s securities, without the prior written consent of Agent, Borrower shall not (i) pay any dividends or make any distributions on its Equity Securities; (ii) purchase, redeem, retire,
defease or otherwise acquire for value any of its Equity Securities (other than repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements or similar arrangements in an aggregate amount not to exceed
$100,000); (iii) return any capital to any holder of its Equity Securities as such; (iv) make any distribution of assets, Equity Securities, obligations or securities to any holder of its Equity Securities as such; or (v) set apart
any sum for any such purpose; provided, however, Borrower may declare dividends payable solely in common stock. 
 Section
5.16    Indebtedness.  Borrower shall not, and shall not permit its Subsidiaries to, create, incur, assume or suffer to exist any Indebtedness, other than Permitted Indebtedness. 

Section 5.17    Investments.  Borrower shall not, and shall not permit its Subsidiaries to, directly or
indirectly acquire or own, or make any Investment in or to any Person other than Permitted Investments; or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that restricts such Subsidiary from paying dividends or
otherwise distributing property to Borrower. 
 Section 5.18    Transactions with Affiliates.  Borrower
shall not, and shall not permit its Subsidiaries to, directly or indirectly enter into or permit to exist any material transaction with any Affiliate, except for transactions that are in the ordinary course of such Person’s business, upon fair
and reasonable terms that are no less favorable to Borrower, or such Subsidiary, than would be obtained in an arms’ length transaction with a non-affiliated Person; provided that the foregoing restriction shall not apply to (i) any
transaction 

  
 -9- 

 
between Borrower and any of its Subsidiaries or between any Subsidiaries that is not otherwise prohibited by this Loan Agreement, (ii) reasonable and customary fees paid to members of the
board of directors of Borrower and its Subsidiaries, and (iii) compensation arrangements and benefit plans for officers and other employees of Borrower and its Subsidiaries entered into or maintained in the ordinary course of business.

 Section 5.19    Indebtedness Payments.  Borrower shall not (i) prepay, redeem, purchase,
defease or otherwise satisfy in any manner prior to the scheduled repayment thereof any Indebtedness for borrowed money (other than amounts due or permitted to be prepaid under this Loan Agreement) or any lease obligations, (ii) amend, modify
or otherwise change the terms of any Indebtedness (other than the Advances) or lease obligations so as to accelerate the scheduled repayment thereof or (iii) repay any Indebtedness to officers, directors or shareholders. 

Section 5.20    Accounts.  Borrower shall not, and shall not permit its Subsidiaries to, maintain any deposit
accounts or securities accounts except accounts with respect to which Agent has obtained an agreement with the bank or other financial institution sufficient to perfect a security interest in such deposit accounts or securities accounts. 

Article 6.    PRESERVATION OF COLLATERAL BY AGENT. 
 Should Borrower fail or refuse to make any payment, perform or observe any other covenant, condition or obligation, or take any other action which Borrower is obligated under any Transaction Document to make,
perform, observe, take or do at the time or in the manner provided in any Transaction Document, then at Agent’s reasonable discretion, without demand upon (but with notice to) Borrower and without releasing Borrower from any obligation,
covenant or condition in any Transaction Document, Agent may make, perform, observe, take or do the same in such manner and to such extent as Agent may deem necessary to protect its security interest in or the value of the Collateral. In furtherance
of the foregoing rights, Borrower does hereby irrevocably appoint Agent (which appointment is coupled with an interest), the true and lawful attorney-in-fact of Borrower with full power of substitution, for it and in its name (i) to perform
(but Agent shall not be obligated to and shall incur no liability to Borrower or any third party for failure to perform) any act which Borrower is obligated by this Loan Agreement to perform, (ii) to ask, demand, collect, receive, receipt for,
sue for, compound and give acquittance for any and all rents, issues, profits, avails, distributions, income, payment draws and other sums in which a security interest is granted under Section 2.01 with full power to settle, adjust or
compromise any claim thereunder as fully as if Agent were Borrower itself, (iii) to receive payment of and to endorse the name of Borrower to any items of Collateral (including checks, drafts and other orders for the payment of money) that come
into Agent’s possession or under Agent’s control, (iv) to make all demands, consents and waivers, or take any other action with respect to, the Collateral, (v) in Agent’s discretion, to file any claim or take any other
action or institute proceedings, either in its own name or in the name of Borrower or otherwise, which Agent may reasonably deem necessary or appropriate to protect and preserve the right, title and interest of Agent in and to the Collateral, and
(vi) to otherwise act with respect thereto as though Agent were the outright owner of the Collateral; provided, however, that the power of attorney herein granted shall be exercisable only upon the occurrence and during the
continuation of an Event of Default unless in Agent’s reasonable opinion immediate action is necessary to preserve or protect the Collateral. Borrower agrees to reimburse Agent upon demand for all reasonable costs and expenses, including
attorneys’ fees and expenses, which Agent may incur while acting as Borrower’s attorney in fact or otherwise under this Article 6, all of which costs and expenses are included within the Obligations. 

  
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 Article 7.    EVENTS OF
DEFAULT. 
 Section 7.01    Events of Default.  The occurrence of any of the following shall
constitute an “Event of Default” under the Transaction Documents: 
  

	 	(a)	Failure to Pay.  Borrower shall fail to pay when due any principal, interest or other payment required under the terms of this Loan Agreement or any other
Transaction Document on the date due and such payment shall not have been made within five (5) Business Days of the due date; or 

  

	 	(b)	Insurance.  Borrower or any of its Subsidiaries shall fail to observe or perform any covenant set forth in Section 5.06 and such failure shall continue for
a period of ten (10) Business Days after notice thereof is received by Borrower from Agent; or 

  

	 	(c)	Breaches of Other Covenants.  Borrower or any of its Subsidiaries shall fail to perform or observe (i) any of the terms, covenants or agreements contained
in Sections 5.03, 5.05, or 5.11 through 5.20 hereof or (ii) any other term, covenant, or agreement contained in any Transaction Document (other than the other Events of Default specified in this Article 7) and such failure remains
unremedied for the earlier of twenty (20) days from (x) the date on which the Agent has given the Borrower written notice of such failure and (y) the date on which the Borrower knew of such failure; or 

 

	 	(d)	Representations and Warranties.  Any representation, warranty, certificate, or other statement (financial or otherwise) made or furnished by or on behalf of
Borrower to Agent in writing in connection with this Loan Agreement or any of the other Transaction Documents, or as an inducement to Agent or Lenders to enter into the Transaction Documents, shall be false, incorrect, incomplete or misleading in
any material respect when made or furnished; or 

  

	 	(e)	Other Payment Obligations.  Borrower or any of its Subsidiaries shall fail to make any payment when due under the terms of any Indebtedness to be paid by such
Person (excluding this Loan Agreement and the other Transaction Documents but including any other Indebtedness of Borrower or any of its Subsidiaries to Agent or any Lender) and such failure shall continue beyond any period of grace provided with
respect thereto, or shall default in the observance or performance of any other agreement, term or condition contained in any such Indebtedness, and the effect of such failure or default is to cause, or permit the holder or holders thereof to cause
Indebtedness in an aggregate amount of One Hundred Thousand Dollars ($100,000) or more to become due prior to its stated date of maturity; or 

  

	 	(f)	Voluntary Bankruptcy or Insolvency Proceedings.  Borrower or any of its Subsidiaries shall (i) apply for or consent to the appointment of a receiver,
trustee, liquidator or custodian of itself or of all or a substantial part of its property, (ii) be unable, or admit in writing its inability, to pay its debts generally as they mature, (iii) make a general assignment for the benefit of
its or any of its creditors, (iv) be dissolved or liquidated in full or in part, (v) become insolvent (as such term may be defined or interpreted under any applicable statute), (vi) commence a voluntary case or other proceeding
seeking liquidation, reorganization or other relief with respect to itself or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or consent to any such relief or to the appointment of or taking possession of
its property by any official in an involuntary case or other proceeding commenced against it, or (vii) take any action for the purpose of affecting any of the foregoing; or 

 

	 	(g)	 Involuntary Bankruptcy or Insolvency Proceedings.  Proceedings for the appointment of a receiver, trustee, liquidator or custodian of Borrower
or any of its Subsidiaries or of all or a substantial part of the property thereof, or an involuntary case or other proceedings seeking liquidation, reorganization or other relief with respect to Borrower or any of its Subsidiaries or the debts
thereof under any bankruptcy, insolvency or other similar law now or hereafter in effect shall be commenced and an 

  
 -11- 

	 	 
order for relief entered or such proceeding shall not be dismissed or discharged within thirty (30) days of commencement; or 

 

	 	(h)	Judgments.  A final judgment or order for the payment of money in excess of One Hundred Thousand Dollars ($100,000) shall be rendered against Borrower or any of
its Subsidiaries and the same shall remain undischarged for a period of thirty (30) days during which execution shall not be effectively stayed, or any judgment, writ, assessment, warrant of attachment, or execution or similar process shall be
issued or levied against a substantial part of the property of Borrower or any of its Subsidiaries and such judgment, writ, or similar process shall not be released, stayed, vacated or otherwise dismissed within thirty (30) days after issue or
levy; or 

  

	 	(i)	Transaction Documents.  Any Transaction Document or any material term thereof shall cease to be, or be asserted by Borrower not to be, a legal, valid and binding
obligation of Borrower enforceable in accordance with its terms or if the Liens of Agent in the Collateral shall cease to be or shall not be valid, first priority perfected Liens or Borrower shall assert that such Liens are not valid, first priority
and perfected Liens. 

 Article 8.    AGENT’S RIGHTS AND REMEDIES 

Section 8.01    Rights of Agent upon Default.  Upon the occurrence and during the existence of any Event of
Default (other than an Event of Default referred to in Sections 7.01(f) and 7.01(g)) and at any time thereafter during the continuance of such Event of Default, Agent may, by written notice to Borrower, declare all outstanding Obligations,
including, without limitation, the non-cancelable obligation to make each payment scheduled to be made under Sections 1.02(b), 1.02(c) and 1.02(d), payable by Borrower hereunder to be immediately due and payable without presentment, demand, protest
or any other notice of any kind, all of which are hereby expressly waived, anything contained herein or in the Notes to the contrary notwithstanding. Upon the occurrence or existence of any Event of Default described in Sections 7.01(f) and
7.01(g), immediately and without notice, all outstanding Obligations, including, without limitation, the non-cancelable obligation to make each payment scheduled to be made under Sections 1.02(b), 1.02(c) and 1.02(d), payable by Borrower hereunder
shall automatically become immediately due and payable, without presentment, demand, protest or any other notice of any kind, all of which are hereby expressly waived, anything contained herein or in the Notes to the contrary notwithstanding.

 Section 8.02    Rights Regarding Collateral.  Borrower agrees that when any Event of Default has
occurred and is continuing, Lenders or Agent, on behalf of Lenders, shall have the rights, options, duties and remedies of a secured party as permitted by law and, in addition to and without limiting the foregoing, Lenders or Agent may, at the
election of Lenders, exercise any one or more or all, and in any order, of the remedies herein set forth, including the following: (i) Agent or Lenders, personally or by agents or attorneys, shall have the right (subject to compliance with any
applicable mandatory legal requirements) to require Borrower to assemble the Collateral and make it available to Agent at a place to be designated by Agent in California or to take immediate possession of the Collateral, or any portion thereof, and
for that purpose may pursue the same wherever it may be found, and may enter any premises of Borrower, with or without notice, demand, process of law or legal procedure, to the extent permitted by applicable law, and search for, take possession of,
remove, keep and store the same, or use and operate or lease the same until sold; (ii) Agent or Lenders may, if at the time such action may be lawful and always subject to compliance with any mandatory legal requirements, either with or without
taking possession and either before or after taking possession, without instituting any legal proceedings whatsoever, having first given notice of such sale by registered or certified mail to Borrower once at least ten (10) days prior to the
date of such sale, and having first given any other notice which may be required by law, sell and dispose of the Collateral, or any part thereof, at a private sale or at public auction, to the highest bidder, in one lot as an entirety or in separate
lots, and either for cash or on credit and on such terms as Lenders may determine, and at any place (whether or not it be the location of the Collateral or any part thereof) designated in the notice referred to above. Agent and its agents and any
purchasers at or after foreclosure are hereby granted a non-exclusive, irrevocable, perpetual, fully paid, royalty-free license or other right, solely pursuant to the provisions of this Section 8.02, to use, without charge,

  
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Borrower’s intellectual property that remains embedded or contained in the Collateral, including without limitation, labels, patents, copyrights, rights of use of any name, trade secrets,
trade names, trademarks, service marks, and advertising matter, or any property of a similar nature, now or at any time hereafter owned or acquired by Borrower or in which Borrower now or at any time hereafter has any rights; provided,
however, such license shall only be exercisable in connection with the disposition of Collateral upon Agent’s or Lenders’ exercise of their remedies hereunder. To the extent permitted by applicable law, any such sale or sales may be
adjourned from time to time by announcement at the time and place appointed for such sale or sales, or for any such adjourned sale or sales, without further published notice, and Borrower, Agent, Lenders, or the holder or holders of the Note, or of
any interest therein, may bid and become the purchaser at any such sale; and (iii) Agent or Lenders may proceed to protect and enforce this Loan Agreement and the other Transaction Documents by suit or suits or proceedings in equity, at law or
in bankruptcy, and whether for the specific performance of any covenant or agreement herein contained or in execution or aid of any power herein granted; or for foreclosure hereunder, or for the appointment of a receiver or receivers for any real
property security or any part thereof, or for the recovery of judgment for the Obligations or for the enforcement of any other proper, legal or equitable remedy available under applicable law. With respect to any of Borrower’s owned premises,
Borrower hereby grants Agent a license to enter into possession of such premises and to occupy the same, without charge, for up to one hundred twenty (120) days in order to exercise any of Agent’s or Lenders’ rights or remedies
provided herein, at law, in equity, or otherwise. 
 Section 8.03    Agent’s Liability for
Collateral.  So long as Agent complies with its obligations, if any, under the Code, neither Agent nor Lenders shall in any way or manner be liable or responsible for: (i) the safekeeping of the Collateral; (ii) any loss
or damage thereto occurring or arising in any manner of fashion from any cause other than Agent’s or such Lender’s gross negligence or willful misconduct; (iii) any diminution in the value thereof; or (iv) any act or default of
any carrier, warehouseman, bailee, forwarding agency, or other Person whomsoever. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 
 Section 8.04    Application of Collateral Proceeds.  The proceeds and/or avails of the Collateral, or any part thereof, and the proceeds and the avails of any remedy
hereunder (as well as any other amounts of any kind held by Agent at the time of, or received by Agent after, the occurrence of an Event of Default hereunder) shall be paid to and applied as follows: (i) First, to the payment of reasonable
costs and expenses, including all amounts expended to preserve the value of the Collateral, of foreclosure or suit, if any, and of such sale and the exercise of any other rights or remedies, and of all proper fees, expenses, liability and advances,
including reasonable legal expenses and attorneys’ fees, incurred or made hereunder by Agent or Lenders; (ii) Second, to the payment to Lenders pro rata in accordance with the Advance Percentages of the amounts then owing or unpaid on the
Notes, including each payment scheduled to be made under Sections 1.02(b), 1.02(c) and 1.02(d) of this Loan Agreement; (iii) Third, to the payment of other amounts then payable to Agent or Lenders under any of the Transaction Documents; and
(iv) Fourth, to the payment of the surplus, if any, to Borrower, its successors and assigns, or to whomsoever may be lawfully entitled to receive the same. In the event that, notwithstanding the foregoing, proceeds and/or avails of the
Collateral, shall be received by a Lender in excess of its ratable share, then the portion of such payment or distribution in excess of such Lender’s ratable share shall be received by such Lender in trust for and shall be promptly paid over to
the other Lenders ratably for application to the payments of amounts due to the other Lenders. 
 Section
8.05    Reinstatement of Rights.  If Agent shall have proceeded to enforce any right under this Loan Agreement or any other Transaction Document by foreclosure, sale, entry or otherwise, and such
proceedings shall have been discontinued or abandoned for any reason or shall have been determined adversely, then and in every such case (unless otherwise ordered by a court of competent jurisdiction), Agent shall be restored to its former position
and its rights hereunder with respect to the property subject to the security interest created under this Loan Agreement shall be reinstated. 

Section 8.06    Agency for Perfection.  Each Lender hereby appoints Agent and each other Lender as agent and
bailee for the purpose of perfecting the security interests in and liens upon the Collateral in assets which, in accordance with the California Uniform Commercial Code, can be perfected only by possession or

  
 -13- 

 
control (or where the security interest of a secured party with possession or control has priority over the security interest of another secured party) and Agent and each Lender hereby
acknowledges that it holds possession or control of any such Collateral for the benefit of the Agent as secured party. Should any Lender obtain possession or control of any such Collateral, such Lender shall notify the Agent thereof, and, promptly
upon the Agent’s request therefor shall deliver possession or control of such Collateral to the Agent or in accordance with the Agent’s instructions. Borrower by its execution and delivery of this Loan Agreement hereby consents
to the foregoing. 
 Article 9.    MISCELLANEOUS. 
 Section 9.01    Modifications, Amendments or Waivers.  The provisions of any Transaction Document may be modified, amended or waived only by a written instrument
signed by the parties thereto. 
 Section 9.02    No Implied Waivers; Cumulative Remedies; Writing
Required.  No delay or failure of Agent or any Lender in exercising any right, power or remedy hereunder shall affect or operate as a waiver thereof; nor shall any single or partial exercise thereof or any abandonment or
discontinuance of steps to enforce such a right, power or remedy preclude any further exercise thereof or of any other right, power or remedy. The rights and remedies hereunder of Agent and the Lenders are cumulative and not exclusive of any rights
or remedies which they would otherwise have. Any waiver, permit, consent or approval of any kind or character on the part of Agent or any Lender of any breach or default under this Loan Agreement or any such waiver of any provision or condition of
this Loan Agreement must be in writing and shall be effective only in the specified instance and to the extent specifically set forth in such writing. 

Section 9.03    Reimbursement.  Borrower shall reimburse Agent and the Lenders for all reasonable costs and
expenses, including without limitation, reasonable attorneys’ fees and disbursements expended or incurred in any arbitration, mediation, judicial reference, legal action or otherwise in connection with (i) the amendment and enforcement of
the Transaction Documents, including without limitation during any workout, attempted workout and/or in connection with the rendering of legal advice as to Agent’s or Lenders’ rights, remedies and obligations under the Transaction
Documents, (ii) collecting any sum which becomes due Agent or Lender under any Transaction Document, (iii) any proceeding for declaratory relief, any counterclaim to any proceeding, or any appeal, or (v) the protection, preservation
or enforcement of any rights of Agent or Lender. For the purpose of this section, attorneys’ fees shall include, without limitation, fees incurred in connection with the following: (1) contempt proceedings; (2) discovery, (3) any
motion, proceeding or other activity of any kind in connection with an insolvency proceeding; (4) garnishment, levy, and debtor and third party examinations; and (5) post-judgment motions and proceedings of any kind, including without
limitation, any activity taken to collect or enforce any judgment. All of the foregoing costs and expenses shall be payable by Borrower upon demand by Agent, and if not paid within thirty (30) days of presentation of invoices shall bear
interest at the highest applicable Default Rate. 
 Section 9.04    Indemnification.  Borrower agrees
upon demand to pay or reimburse Agent and the Lenders for all liabilities, obligations and out-of-pocket expenses, including reasonable fees and expenses of counsel for Agent and the Lenders, from time to time arising in connection with the
enforcement or collection of sums due under the Transaction Documents. Borrower shall indemnify, reimburse and hold Agent and the Lenders and their permitted assigns, each of Agent’s, Lenders’ or their permitted assigns’ partners, and
each of their respective successors, assigns, agents, officers, directors, shareholders, servants, agents and employees harmless from and against all liabilities, losses, damages, actions, suits, demands, claims of any kind and nature (including
claims relating to environmental discharge, cleanup or compliance), all costs and expenses whatsoever to the extent they may be incurred or suffered by such indemnified party in connection therewith (including reasonable attorneys’ fees and
expenses), fines, penalties (and other charges of applicable governmental authorities), licensing fees relating to any item of Collateral, damage to or loss of use of property (including consequential or special damages to third parties or damages
to Borrower’s property), or bodily injury to or death of any person (including any agent or employee of Borrower) (each, a “Claim”), directly or indirectly relating to or arising out of the use of the proceeds of the
Advance, including acquisition, use, ownership, operation, possession, control, storage, return or condition of any item of Equipment 

  
 -14- 

 
constituting Collateral (regardless of whether such item of Equipment is at the time in the possession of Borrower), the falsity of any representation or warranty of Borrower or Borrower’s
failure to comply with the terms of this Loan Agreement or any other Transaction Document. The foregoing indemnity shall cover, without limitation, (i) any Claim in connection with a design or other defect (latent or patent) in any item of
Equipment constituting Collateral, (ii) any Claim for infringement of any patent, copyright, trademark or other intellectual property right, (iii) any Claim resulting from the presence on or under or the escape, seepage, leakage, spillage,
discharge, emission or release of any Hazardous Materials from any item of Equipment financed by an Advance or constituting Collateral, including any Claims asserted or arising under any Environmental Law, or (iv) any Claim for negligence or
strict or absolute liability in tort; provided, however, that Borrower shall not indemnify Agent or any Lender for any liability incurred by such Person as a direct and sole result of that Person’s gross negligence or willful
misconduct. Such indemnities shall continue in full force and effect, notwithstanding the expiration or termination of this Loan Agreement. Upon Agent’s written demand, Borrower shall assume and diligently conduct, at its sole cost and expense,
the entire defense of Agent or any Lender and its permitted assigns, each of Agent’s, Lenders’ or their permitted assigns’ partners, and each of their respective successors, assigns, agents, officers, directors, shareholders,
servants, agents and employees against any indemnified Claim described in this Section 9.04. Borrower shall not settle or compromise any Claim against or involving Agent or any Lender without first obtaining such Person’s written consent
thereto, which consent shall not be unreasonably withheld. The obligations in this Section 9.04 shall survive payment of all other Obligations until all applicable statute of limitation periods with respect to actions that may be brought
against Agent or Lenders have run. All amounts owing under this Section 9.04 shall be paid within thirty (30) days after written demand. 

Section 9.05    Limitation on Damages.  NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS LOAN
AGREEMENT OR ANYWHERE ELSE, BORROWER AGREES THAT IT SHALL NOT SEEK FROM AGENT OR ANY LENDER UNDER ANY THEORY OF LIABILITY (INCLUDING ANY THEORY IN TORTS), ANY SPECIAL, INDIRECT, CONSEQUENTIAL OR PUNITIVE DAMAGES. 

Section 9.06    Disbursements and Payments. 

 

	 	(a)	Disbursements.  Lenders shall disburse each Advance to Borrower according to the following account and wire transfer instructions: 

 

			
	Credit:	  	
	Further Credit	  	
	Bank Name:	  	
	Bank Address:	  	
	Account Number:	  	
	ABA Routing Number:	  	
	Reference:	  	

  

	 	(b)	Regularly Scheduled Payments.  All regularly scheduled payments due to Agent shall be effected by automatic debit of the appropriate funds from Borrower’s
primary operating account set forth below: 

  
 -15- 

  

			
	Account Holder:	  	
	Bank Name:	  	
	Further Credit	  	
	Bank Address:	  	
	Account Number:	  	
	ABA Routing Number:	  	

  

	 	(c)	Other Payments.  All payments to Agent other than regularly scheduled payments may be made via wire transfer as follows: 

 

			
	Wire Transfer Payment	  	
		
	Credit:	  	
	Bank Name:	  	
	Bank Address:	  	
		  	
	Account Number:	  	
	ABA Routing Number:	  	
	Reference:	  	

 Section 9.07    Notices.  All notices and other communications given to
or made upon any party hereto in connection with this Loan Agreement shall be in writing and (except for financial statements and other informational documents which may be sent by email) shall be delivered by certified mail, postage prepaid, return
receipt requested, by a nationally recognized overnight courier, or by prepaid facsimile or personally delivered to the respective parties, as follows: 
  

			
	Borrower:	  	ACELRX PHARMACEUTICALS, INC.
		  	575 Chesapeake Drive
		  	Redwood City, CA 94063
		  	Telephone: 650.216.3516
		  	Telecopier: 650.216.6500
		  	Attention: Carter King, Vice President, Finance
		
	Agent:	  	PINNACLE VENTURES, L.L.C.
		  	130 Lytton Avenue, Suite 220
		  	Palo Alto, CA 94301
		  	Telephone: (650) 926-7800
		  	Telecopier: (650) 926-7801
		  	Email: rsavoie@pinnacleventures.com
		  	Attention: Chief Operating Officer

 or in accordance with any
subsequent written direction from either party to the other. All such notices and other communications shall, except as otherwise expressly herein provided, be effective when received; or in the case of delivery by messenger or overnight delivery
service, when left at the appropriate address. 
 Section 9.08    Lenders and Allocations of
Advances.  Notwithstanding anything herein to the contrary, each Lender severally commits to make such Lender’s Advance Percentage of each Advance. No Lender shall have liability for the commitment to make Advances of any
other Lender. Borrower agrees that by notice to Borrower, Agent may reallocate the Advance Percentages among the Lenders or among the Lenders and other investment funds affiliated with Agent. Whether or not specified in any provision of this Loan
Agreement, all references to Agent in this Loan Agreement shall mean Agent for the benefit of the Lenders unless the context otherwise requires. 

  
 -16- 

  
 Section
9.09    Severability.  If any provision of any Transaction Document is held invalid or unenforceable to any extent or in any application, the remainder of such Transaction Document and all other
Transaction Documents, or the application of such provision to different Persons or circumstances or in different jurisdictions, shall not be affected thereby. 
 Section 9.10    Reliance by Agent and the Lenders.  All covenants, agreements, representations and warranties made herein by Borrower shall be deemed to have been
relied upon by Agent and the Lenders, notwithstanding investigation by Agent. 
 Section 9.11    No Set-Offs by
Borrower.  All sums payable by Borrower pursuant to this Loan Agreement or any of the other Transaction Documents shall be payable without notice or demand and shall be payable without set-off or reduction of any manner whatsoever.

 Section 9.12    Survival.  All representations, warranties, covenants and agreements of Borrower
contained herein or made in writing in connection herewith shall survive the execution and delivery of the Transaction Documents, the making of Advances hereunder, the granting of security and the issuance of the Notes. 

Section 9.13    Confidentiality.  Agent and the Lenders agree to hold non-public information received in
confidence and shall not disclose such information to third parties except to their employees, members, partners or the partners of its affiliated investment funds, their lenders, and professional advisors to the foregoing, including attorneys and
accountants, and others under a similar duty of confidentiality, and as Agent may deem necessary in its reasonable judgment to satisfy its legal obligations or to enforce Agent’s or Lenders’ rights under any Transaction Document. Borrower
acknowledges that Lenders may issue press releases, advertisements, and other promotional materials, either in print or on Lenders’ website(s), describing any successful outcome of services provided on Borrower’s behalf. Borrower agrees
that Lenders shall have the right to identify Borrower by name and use Borrower’s corporate logo in those materials, solely for marketing purposes. 

Section 9.14    Choice of Law and Venue; Jury Trial Waiver.  THIS LOAN AGREEMENT SHALL BE GOVERNED BY, AND
CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. BORROWER, AGENT AND THE LENDERS HEREBY SUBMIT TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS LOCATED IN THE
NORTHERN DISTRICT OF CALIFORNIA. BORROWER, AGENT AND THE LENDERS HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF ANY OF THE TRANSACTION DOCUMENTS OR ANY OF THE TRANSACTIONS
CONTEMPLATED THEREIN, INCLUDING CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW OR STATUTORY CLAIMS. 
 Section
9.15    Successors and Assigns.  This Loan Agreement and the other Transaction Documents shall be binding upon and inure to the benefit of Agent and the Lenders, all future holders of the Note,
Borrower and their respective successors and permitted assigns, except that Borrower may not assign or transfer its rights hereunder or thereunder or any interest herein or therein without the prior written consent of Agent unless (A) the
Obligations are assumed or guaranteed by the Acquirer or the ultimate parent entity of the Acquirer, and (B) the Acquirer is a creditworthy entity (as determined by Agent in its reasonable discretion). Agent or Lenders may assign all or any
portion of their rights hereunder and under one or more Notes to any of its affiliated investment funds or to any one or more financial institutions or funds or an agent or trustee for such financial institutions or funds (an
“Assignee”) and may sell to any of its affiliated investment funds or to any one or more financial institutions or funds or an agent or trustee for such financial institutions or funds (a
“Participant”) participation interests in Agent’s or Lenders’ rights hereunder and under one or more Notes. Agent and the Lenders may disclose the Transaction Documents and any other financial or other information
relating to Borrower or any Subsidiary to any potential Assignee or Participant, provided that such Participant agrees to protect the confidentiality of such documents and information using the same measures that it uses to protect its own
confidential information. 

  
 -17- 

  
 Section
9.16    Counterparts.  This Loan Agreement may be executed in any number of counterparts and by different parties hereto on separate counterparts, each of which, when so executed and delivered, shall
be an original, but all such counterparts shall together constitute one and the same instrument. 
 Section
9.17    Further Assurances.  Borrower will, at its own expense, from time to time do, execute, acknowledge and deliver all and every further acts, deeds, conveyances, transfers and assurances, and all
financing and continuation statements and similar notices, reasonably necessary or proper for the perfection of the security interest being herein provided for in the Collateral, whether now owned or hereafter acquired. 

Section 9.18    Entire Agreement.  This Loan Agreement and each of the other Transaction Documents, taken
together, constitute and contain the entire agreement of Borrower, Agent and the Lenders and supersede any and all prior agreements, negotiations, correspondence, understandings and communications among the parties, whether written or oral,
respecting the subject matter hereof. 
 Section 9.19    Equity Investment.  Borrower shall permit
Agent and the Lenders, at their option, to purchase in Borrower’s next round of private equity financing the securities sold in such equity financing at the same price and on the same terms as paid and received by the lead investor of the
equity financing in an aggregate amount of up to five percent (5.0%) of the aggregate amount of the equity financing. Borrower agrees that it shall notify Agent promptly upon the execution by Borrower of a term sheet or letter of intent setting
forth the terms and conditions of such financing and in any event within ten (10) days of such execution. Within twenty (20) days of receipt of such notice from Borrower, Agent and the Lenders agree that they shall notify Borrower in
writing of their intent to purchase securities in such financing. Agent and the Lenders may assign this right of purchase to their Affiliates. 

Article 10.    DEFINITIONS. 
 All terms defined in the Code shall have the respective meanings specified in the Code. In addition, for purposes of this Loan Agreement the following capitalized terms shall have the meanings set forth below:

 “Advance” shall have the meaning set forth in Section 1.01 of this Loan Agreement. 

“Advance Percentage” shall mean, with respect to a Lender, the percentage of each Advance specified opposite such
Lender’s name on Schedule 1 hereto. 
 “Affiliate” shall mean any Person that owns or controls directly or
indirectly ten percent (10%) or more of the stock of another entity, any Person that controls or is controlled by or is under common control with such Persons or any Affiliate of such Persons and each of such Person’s officers, directors,
members, joint venturers or partners. When used with respect to a Lender, Affiliate shall also include any Affiliate of Agent. 

“Borrower’s Books” shall mean all of Borrower’s books and records including without limitation: ledgers; records
concerning Borrower’s assets or liabilities, the Collateral, business operations or financial condition; and all computer programs, or tape files, and the equipment, containing such information. 

“Borrower’s Primary Operating Account” shall have the meaning set forth in Section 5.05 of this Loan Agreement.

 “Business Day” shall mean any day on which commercial banks are not authorized or required to close in San
Francisco, California. 
 “Closing” shall mean the date, time and place as the parties may agree for the execution
of this Loan Agreement. 

  
 -18- 

  
 “Code”
shall mean the Uniform Commercial Code as in effect from time to time in the state of California. 
 “Collateral”
shall mean property described on Exhibit B attached hereto. 
 “Commitment” shall have the meaning set
forth in Section 1.01 of this Loan Agreement. 
 “Contractual Obligation” of any Person shall mean, any
indenture, note, security, deed of trust, mortgage, security agreement, lease, guaranty, instrument, contract, agreement or other form of obligation or undertaking to which such Person is a party or by which such Person or any of its property is
bound. 
 “Copyrights” shall mean any and all copyright rights, copyright applications, copyright registrations
and like protections in each work or authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret, now or hereafter existing, created, acquired or held. 

“Default” shall mean any event or circumstance not yet constituting an Event of Default but which, with the giving of any
notice or the lapse of any period of time or both, would become an Event of Default. 
 “Default Rate” shall mean,
as of any date of determination, an interest rate per annum equal to five percent (5%) in excess of the rate per annum otherwise applicable on such date. 
 “Environmental Laws” shall mean all Requirements of Law relating to the protection of human health or the environment, including, without limitation, (i) all Requirements of Law,
pertaining to reporting, licensing, permitting, investigation, and remediation of emissions, discharges, releases, or threatened releases of hazardous materials, chemical substances, pollutants, contaminants, or hazardous or toxic substances,
materials or wastes whether solid, liquid, or gaseous in nature, into the air, surface water, groundwater, or land, or relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport, or handling of chemical
substances, pollutants, contaminants, or hazardous or toxic substances, materials, or wastes, whether solid, liquid, or gaseous in nature; and (ii) all Requirements of Law pertaining to the protection of the health and safety of employees or
the public. 
 “Equipment” shall mean all present and future machinery, equipment, tenant improvements, furniture,
fixtures, vehicles, tools, parts and attachments in which Borrower has any interest. 
 “Equity Securities” of any
Person shall mean (i) all common stock, preferred stock, participations, shares, partnership interests, membership interests or other equity interests in and of such Person (regardless of how designated and whether or not voting or non-voting)
and (ii) all warrants, options and other rights to acquire any of the foregoing. 
 “Event of Default” shall
have the meaning set forth in Article 7 of this Loan Agreement. 
 “Event of Loss” shall have the meaning set
forth in Section 5.11(a) of this Loan Agreement. 
 “Financial Statements” shall mean, with respect to any
accounting period for any Person, statements of operations, retained earnings and cash flow of such Person for such period, and balance sheets of such Person as of the end of such period, setting forth in each case in comparative form figures for
the corresponding period in the preceding fiscal year if such period is less than a full fiscal year or, if such period is a full fiscal year, corresponding figures from the preceding fiscal year, all prepared in reasonable detail and in accordance
with generally accepted accounting principles, except in the case of unaudited Financial Statements, for the absence of footnotes and normal year-end adjustments. Unless otherwise indicated, each reference to Financial Statements of any Person shall
be deemed to refer to Financial Statements prepared on a consolidated basis. 

  
 -19- 

  
 “Funding
Date” shall mean any date on which an Advance is made to or on account of Borrower under this Loan Agreement. 

“Funding Termination Date” shall have the meaning set forth in Section 1.01 of this Loan Agreement. 

“Governmental Authority” shall mean any domestic or foreign national, state or local government, any political subdivision
thereof, any department, agency, authority or bureau of any of the foregoing, or any other entity exercising executive, legislative, judicial, regulatory or administrative functions of or pertaining to government. 

“Governmental Rule” shall mean any law, rule, regulation, ordinance, order, code interpretation, judgment, decree,
directive, guidelines, policy or similar form of decision of any Governmental Authority. 
 “Indebtedness” of any
Person shall mean and include the aggregate amount of, without duplication (i) all obligations of such Person for borrowed money, (ii) all obligations of such Person evidenced by bonds, debentures, notes or other similar instruments,
(iii) all obligations of such Person to pay the deferred purchase price of property or services (other than accounts payable incurred in the ordinary course of business determined in accordance with generally accepted accounting principles),
(iv) all obligations under capital leases of such Person, (v) all obligations or liabilities of others secured by a lien on any asset of such Person, whether or not such obligation or liability is assumed, (vi) all guaranties of such
Person of the obligations of another Person, (vii) all obligations created or arising under any conditional sale or other title retention agreement with respect to property acquired by such Person (even if the rights and remedies of the seller
or lender under such agreement upon an event of default are limited to repossession or sale of such property), (viii) net exposure under any interest rate swap, currency swap, forward, cap, floor or other similar contract that is not entered to
in connection with a bona fide hedging operation that provides offsetting benefits to such Person, which agreements shall be marked to market on a current basis, and (ix) all reimbursement and other payment obligations, contingent or otherwise,
in respect of letters of credit. 
 “Intellectual Property” shall mean: (i) Copyrights,
Trademarks, Patents, and Mask Works; (ii) any and all trade secrets, and any and all intellectual property rights in computer software and computer software products now or hereafter existing, created, acquired or held; (iii) any and all
design rights which may be available to Borrower now or hereafter existing, created, acquired or held; (iv) any and all claims for damages by way of past, present and future infringement of any of the rights included above, with the right, but
not the obligation, to sue for and collect such damages for said use or infringement of the intellectual property rights identified above; (v) all licenses or other rights to use any of the Copyrights, Patents, Trademarks, or Mask Works, and
all license fees and royalties arising from such use; (vi) all amendments, renewals and extensions of any of the Copyrights, Trademarks, Patents or Mask Works; and (vii) all proceeds and products of the foregoing, including without
limitation all payments under insurance or any indemnity or warranty payable in respect of any of the foregoing. 

“Inventory” shall mean all present and future inventory in which Borrower has any interest, including merchandise, raw
materials, parts, supplies, packing and shipping materials, work in process and finished products intended for sale or lease or to be furnished under a contract of service, of every kind and description now or at any time hereafter owned by or in
the custody or possession, actual or constructive, of Borrower, including such inventory as is temporarily out of its custody or possession or in transit and including any returns upon any accounts or other proceeds, including insurance proceeds,
resulting from the sale or disposition of any of the foregoing and any documents of title representing any of the above, and Borrower’s Books relating to any of the foregoing. 

“Investment” shall mean the purchase or acquisition of any capital stock, equity interest, or any obligations or other
securities of, or any interest in, any Person, or the extension of any advance, loan, extension of credit or capital contribution to, or any other investment in, any Person. 

  
 -20- 

  
 “Landlord
Waiver” shall mean the Landlord Waiver substantially in the form attached as Exhibit D hereto. 

“Lien” shall mean, with respect to any property, any security interest, mortgage, pledge, lien, claim, charge or other
encumbrance in, of, or on such property or the income therefrom, including, without limitation, the interest of a vendor or lessor under a conditional sale agreement, capital lease or other title retention agreement, or any agreement to provide any
of the foregoing, and the filing of any financing statement or similar instrument under the Code or comparable law of any jurisdiction. 

“Loan Agreement” shall mean this Loan and Security Agreement, as amended, restated or otherwise modified from time to time.

 “Management Rights Agreement” shall mean a management rights agreement entered into by Borrower and Agent
contemporaneously with the execution of this Loan Agreement. 
 “Mask Works” shall mean all mask works or similar
rights available for the protection of semiconductor chips, now owned or hereafter acquired. 
 “Material Adverse
Effect” shall mean a material adverse effect on (i) the business, assets, operations, prospects or financial or other condition of Borrower and its Subsidiaries, taken as a whole; (ii) the ability of Borrower and its
Subsidiaries to pay or perform the Obligations in accordance with the terms of this Loan Agreement and the other Transaction Documents and to avoid an Event of Default under any Transaction Document; or (iii) the rights and remedies of any
Lender under this Loan Agreement, the other Transaction Documents or any related document, instrument or agreement. 

“Note” shall mean a promissory note or notes of Borrower substantially in the form attached as Exhibit A hereto.

 “Obligations” shall mean and include all loans, advances, debts, liabilities, and obligations, including,
without limitation, the noncancelable obligation to make each payment scheduled to be made under Sections 1.02(b), 1.02(c) and 1.02(d), howsoever arising, owed by Borrower to Lenders of every kind and description (whether or not evidenced by any
note or instrument and whether or not for the payment of money), now existing or hereafter arising under or pursuant to the terms of this Loan Agreement or the other Transaction Documents, including, without limitation, all interest, fees, charges,
expenses, attorneys’ fees and costs and accountants’ fees and costs chargeable to and payable by Borrower hereunder and thereunder, in each case, whether direct or indirect, absolute or contingent, due or to become due, and whether or not
arising after the commencement of a proceeding under Title 11 of the United States Code (11 U.S.C. Section 101 et seq.), as amended from time to time (including post-petition interest) and whether or not allowed or allowable as a claim
in any such proceeding. 
 “Patents” shall mean all patents, patent applications and like protections, including
without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same. 

“Payment Date” shall have the meaning set forth in Section 1.02(b) of this Loan Agreement. 

“Permitted Indebtedness” shall mean: (i) Indebtedness of Borrower in favor of Lenders arising under this Loan
Agreement or any other Transaction Document; (ii) Indebtedness existing at Closing and disclosed on Schedule 2; (iii) Indebtedness secured by a lien described in clause (vi)(A) of the defined term “Permitted
Liens,” provided (A) such Indebtedness does not exceed the lesser of the cost or fair market value of the equipment financed with such Indebtedness, (B) such Indebtedness does not exceed $500,000 in the aggregate at any given time,
and (C) the holder of such Indebtedness agrees to waive any rights of set off such holder may have with respect to such Indebtedness in the deposit or investment accounts of Borrower and its Subsidiaries on terms reasonably satisfactory to
Agent; (iv) Subordinated Debt; (v) Indebtedness 

  
 -21- 

 
incurred for the acquisition of supplies or inventory on normal trade credit; and (vi) extensions, refinancings, modifications, amendments and restatements of any item of Permitted
Indebtedness (i) through (v) above. 
 “Permitted Investments” shall mean: (i) Investments existing
at Closing disclosed on Schedule 2; (ii) consistent with the Company’s Investment Policy, a portfolio with an average maturity of less than one (1) year comprised of instruments with maturities not to exceed two
(2) years at time of purchase, including (A) marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or any State thereof, (B) commercial paper currently having rating of at
least A-2 or P-2 from either Standard & Poor’s Corporation or Moody’s Investors Service, Inc., and (C) certificates of deposit; (iii) temporary advances to cover incidental expenses in the ordinary course of business;
(iv) investments in joint ventures, strategic alliances, licensing and similar arrangements customary in Borrower’s industry and which do not require Borrower to assume or otherwise become liable for the obligations of any third party not
directly related to or arising out of such arrangement or require Borrower to transfer ownership of non-cash assets to such joint venture or other entity; (v) Investments consisting of (A) travel advances, employee relocation loans and
other employee loans and advances in the ordinary course of business not to exceed $50,000 and (B) non-cash loans to employees, officers or directors relating to the purchase of equity securities of Borrower pursuant to employee stock purchase
plans or arrangements approved by Borrower’s board of directors; (vi) Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement of delinquent
obligations of, and other disputes with, customers or suppliers arising in the ordinary course of business; and (vii) Investments consisting of notes receivable or, prepaid royalties and other credit obligations to customers and suppliers who
are not Affiliates, in the ordinary course of business. 
 “Permitted Liens” shall mean and include:
(i) Liens in favor of Agent; (ii) Liens existing at Closing and disclosed on Schedule 2; (iii) other Liens subordinated to the Liens in favor of Agent; (iv) Liens of carriers, warehousemen, mechanics, materialmen,
vendors, and landlords incurred in the ordinary course of business for sums not overdue or being contested in good faith, provided provision is made to the reasonable satisfaction of Agent for the eventual payment thereof if subsequently found
payable; (v) leases or subleases and licenses or sublicenses granted in the ordinary course of Borrower’s business; (vi) Liens (A) upon or in any Equipment which was acquired or held by Borrower or any of its Subsidiaries to
secure the purchase price of such Equipment or indebtedness incurred solely for the purpose of financing the acquisition of such Equipment, or (B) existing on such equipment at the time of its acquisition, provided that the Lien is confined
solely to the property so acquired and improvements thereon, and the proceeds of such equipment; (vii) bankers’ liens, rights of setoff and similar Liens incurred on deposits made in the ordinary course of business; (viii) Liens
arising from judgments, decrees or attachments in circumstances not constituting an Event of Default; (ix) Liens for taxes or other Taxes not at the time delinquent or thereafter payable without penalty or being contested in good faith,
provided provision is made to the reasonable satisfaction of Agent for the eventual payment thereof if subsequently found payable; (x) Liens in favor of customs and revenue authorities arising as a matter of law to secure payments of customs
duties in connection with the importation of goods; (xi) Liens on insurance proceeds in favor of insurance companies granted solely as security for financed premiums; and (xii) Liens incurred in connection with the extension, renewal or
refinancing of the indebtedness secured by Liens of the type described in clauses (i) through (iii) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and
the principal amount of the indebtedness being extended, renewed or refinanced does not increase. 
 “Person”
shall mean and include an individual, a partnership, a corporation (including a business trust), a joint stock company, a limited liability company, an unincorporated association, a joint venture or other entity or a Governmental Authority.

 “Requirement of Law” applicable to any Person shall mean (i) the articles or certificate of incorporation,
bylaws or other governing documents of such Person, (ii) any Governmental Rule applicable to such Person, (iii) any license, permit, approval or other authorization granted by any Governmental Authority to or for the benefit of such Person
and (iv) any judgment, decision or determination of any Governmental 

  
 -22- 

 
Authority or arbitrator, in each case applicable to or binding upon such Person or any of its property or to which such Person or any of its property is subject. 

“Subordinated Debt” shall mean any debt incurred by Borrower that is subordinated to the debt owing by Borrower to Lenders
on terms reasonably acceptable to Lenders (and identified as being such by Borrower and Lenders). 
 “Subsidiary”
of any Person shall mean (i) any corporation of which more than fifty percent (50%) of the issued and outstanding equity securities having ordinary voting power to elect a majority of the Board of Directors of such corporation
(irrespective of whether at the time capital stock of any other class or classes of such corporation shall or might have voting power upon the occurrence of any contingency) is at the time directly or indirectly owned or controlled by such Person,
by such Person and one or more of its other Subsidiaries or by one or more of such Person’s other Subsidiaries, (ii) any partnership, joint venture, or other association of which more than fifty percent (50%) of the equity interest
having the power to vote, direct or control the management of such partnership, joint venture or other association is at the time owned and controlled by such Person, by such Person and one or more of the other Subsidiaries or by one or more of such
Person’s other subsidiaries and (iii) any other Person included in the financial statements of such Person on a consolidated basis. Any reference to a Subsidiary without designation of the ownership of such Subsidiary shall be deemed to
refer to a Subsidiary of Borrower. 
 “Tax” or “Taxes” shall
mean any present or future tax, levy, impost, duty, charge, fee, deduction or withholding of any nature and whatever called, by whomsoever, on whomsoever and wherever imposed, levied, collected, withheld or assessed, including interest, penalties,
additions to tax and any similar liabilities with respect thereto; except that, in the case of a Lender, there shall be excluded (i) taxes that are imposed on the overall net income or net profits (including franchise taxes imposed in lieu
thereof) (a) by the United States, (b) by any other Governmental Authority under the laws of which such Lender is organized or has its principal office or maintains its applicable lending office, or (c) by any jurisdiction solely as a
result of a present or former connection between such Lender and such jurisdiction (other than any such connection arising solely from such Lender having executed, delivered or performed its obligations or received a payment under, or enforced, any
of the Transaction Documents), and (ii) any branch profits taxes imposed by the United States or any similar tax imposed by any other jurisdiction in which such Lender is located. 

“Trademarks” shall mean any trademark and servicemark rights, whether registered or not, applications to register and
registrations of the same and like protections, and the entire goodwill of the business of Borrower connected with and symbolized by such trademarks. 
 “Transaction Documents” shall mean, collectively, the Loan Agreement, the Notes, the Management Rights Agreement, the Warrant Purchase Agreement, the Warrants and the other documents
executed in connection herewith. 
 “Warrant” shall mean a warrant or warrants to purchase capital stock of the
Borrower issued by Borrower to an Affiliate of Lenders pursuant to a Warrant Purchase Agreement contemporaneously with the execution of this Loan Agreement. 
 “Warrant Purchase Agreement” shall mean a warrant purchase agreement under which a Warrant is issued entered into by Borrower and an Affiliate of Lenders contemporaneously with the execution
of this Loan Agreement. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
 -23- 

  
 IN WITNESS WHEREOF, the parties
hereto have executed this Loan Agreement as of the date first written above. 
  

									
	AGENT:	 		 	BORROWER:
			
	PINNACLE VENTURES, L.L.C., 	 		 	ACELRX PHARMACEUTICALS, INC.,
	a Delaware limited liability company	 		 	a Delaware corporation
					
	By:	 	/s/ Robert N. Savoie	 		 	By:	 	/s/ Thomas A. Schreck

									
					
	Name:	 	Robert N. Savoie	 		 	Name:	 	Thomas A. Schreck

									
					
	Title:	 	Chief Operating Officer	 		 	Title:	 	CEO

  

			
	LENDERS:
	
	 PINNACLE VENTURES II-A (SUB), L.P.,
 a Delaware limited partnership
 PINNACLE VENTURES II-B, L.P.,

a Delaware limited partnership
 PINNACLE VENTURES II-C,
L.P.,
 a Delaware limited partnership
 PINNACLE
VENTURES II-R (SUB), L.P.,
 a Delaware limited partnership

		
	By:	 	Pinnacle Ventures Management II, L.L.C.,
their general partner
		
	By:	 	/s/ Robert N. Savoie

			
		
	Name:	 	Robert N. Savoie

			
		
	Title:	 	Chief Financial Officer

 EXECUTION COPY 
 SCHEDULE 1 
  

							
	 Lender
  
	  	 Advance Percentage

 
	 	  	 
	 PINNACLE VENTURES II-A (SUB), L.P.

 
	  	   
	2%              
 
	    
	  
	 PINNACLE VENTURES II-B, L.P.

 
	  	   
	84%              
 
	    
	  
	 PINNACLE VENTURES II-C, L.P.

 
	  	   
	7%              
 
	    
	  
	 PINNACLE VENTURES II-R (SUB), L.P.

 
	  	   
	    7%              
 
	    
	  
	 TOTAL
	  	 	100%              	  	  

 EXECUTION COPY 
 SCHEDULE 2 
  

			
	Other Names:	  	None
		
	Deposit and Securities Accounts:	  	
		
		  	
		
		  	
		
		  	
		
	Other Collateral Locations:	  	None
		
	Existing Indebtedness:	  	Equipment financing of up to $750,000 pursuant to the Security Agreement and Credit Agreement dated March 15, 2007 with Wells Fargo Bank, National Association
		
	Existing Investments:	  	
		
		  	(see Deposit and Securities Accounts above)
		
	Existing Liens:	  	Lien on equipment financed pursuant to the Security Agreement and Credit Agreement dated March 15, 2007 with Wells Fargo Bank, National Association (see Existing Indebtedness
above)

  
 EXHIBIT A 

SECURED PROMISSORY NOTE 

 

					
	 $    12,000,000.00    
	  	 	Dated: November 3, 2008	  

 FOR VALUE RECEIVED, the
undersigned, ACELRX PHARMACEUTICALS, INC. (“Borrower”), a Delaware corporation, HEREBY PROMISES TO PAY to the order of Pinnacle Ventures, L.L.C. (“Agent”) for the account of the Lenders the principal amount of
    Twelve Million     Dollars ($12,000,000.00) or such lesser amount as shall equal the aggregate outstanding principal balance of the Advance made by Agent on the date hereof to Borrower
pursuant to the Loan and Security Agreement referred to below (the “Loan Agreement”), plus all payments arising under Sections 1.02(b) (excluding the portion of the payments representing the original principal amount), 1.02(c) and 1.02(d)
of the Loan Agreement with respect to such Advance, on the dates and in the amounts set forth in the Loan Agreement. Capitalized terms used herein and not otherwise defined have the respective meanings set forth in the Loan Agreement. 

Payments under this Note shall be made as follows: 
  

			
	Interim Payment on Funding Date:	  	$    79,333.33    
		
	 6 monthly payments on the first Business
 Day of
each Month after the Funding Date
	  	$    85,000.00, commencing December 1, 2008
		
	 30 monthly payments on the first Business
 Day of
each Month after the Funding Date
	  	$    442,280.96, commencing June 1, 2009
		
	Final Payment:	  	$    600,000.00 on November 1, 2011

 All other payments due under this Note or under the Loan Agreement shall be payable as and when specified in the Loan Agreement. 
 This Note is one of the Notes referred to in, and is entitled to the benefits of, the Loan and Security Agreement, dated as of September 16, 2008, between Borrower, Agent and the Lenders. This Note and the
obligation of Borrower to repay the unpaid principal amount of the Advance, interest on the Advance, premium, if any, and all other amounts due Agent and Lenders under the Loan Agreement is secured under the Loan Agreement. 

Presentment for payment, demand, notice of protest and all other demands and notices of any kind in connection with the execution, delivery,
performance and enforcement of this Note are hereby waived. 
 Borrower shall pay all reasonable fees and expenses, including, without
limitation, reasonable attorneys’ fees and costs, incurred by Agent or any Lender in the enforcement or attempt to enforce any of Borrower’s obligations hereunder not performed when due. This Note shall be governed by, and construed and
interpreted in accordance with, the laws of the State of California. 

  
 A-1 

  
 IN WITNESS WHEREOF, Borrower has
caused this Note to be duly executed by one of its officers thereunto duly authorized on the date hereof. 
  

			
	 ACELRX PHARMACEUTICALS, INC.,
 a
Delaware corporation

		
	By:	 	/s/    Thomas A.
Schreck

			
		
	Name:	 	Thomas A. Schreck

			
		
	Title:	 	CEO

  
 A-2 

  
 EXHIBIT B 

The Collateral shall consist of all right, title, interest, claims and demands of Borrower in and to the following: 

(a)        All goods and equipment now owned or hereafter acquired, including, without limitation, all
laboratory equipment, computer equipment, office equipment, machinery, fixtures, vehicles, and any interest in any of the foregoing, and all attachments, accessories, accessions, replacements, substitutions, additions, and improvements to any of the
foregoing, wherever located; 
 (b)        All inventory now owned or hereafter acquired,
including, without limitation, all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products including such inventory as is temporarily out of Borrower’s custody or possession or in
transit and including any returns upon any accounts or other proceeds, including insurance proceeds, resulting from the sale or disposition of any of the foregoing and any documents of title representing any of the above, and Borrower’s books
relating to any of the foregoing; 
 (c)        All contract rights, general intangibles, health
care insurance receivables, payment intangibles and commercial tort claims, now owned or hereafter acquired, including, without limitation, all patents, patent rights (and applications and registrations therefor), trademarks and service marks (and
applications and registrations therefor), inventions, copyrights, mask works (and applications and registrations therefor), trade names, trade styles, software and computer programs, trade secrets, methods, processes, know how, drawings,
specifications, descriptions, and all memoranda, notes, and records with respect to any research and development, goodwill, license agreements, franchise agreements, blueprints, drawings, purchase orders, customer lists, route lists, infringements,
claims, computer programs, computer disks, computer tapes, literature, reports, catalogs, design rights, income tax refunds, payments of insurance and rights to payment of any kind and whether in tangible or intangible form or contained on magnetic
media readable by machine together with all such magnetic media; 
 (d)        All now existing
and hereafter arising accounts, contract rights, royalties, license rights and all other forms of obligations owing to Borrower arising out of the sale or lease of goods, the licensing of technology or the rendering of services by Borrower (subject,
in each case, to the contractual rights of third parties to require funds received by Borrower to be expended in a particular manner), whether or not earned by performance, and any and all credit insurance, guaranties, and other security therefor,
as well as all merchandise returned to or reclaimed by Borrower and Borrower’s books relating to any of the foregoing; 

(e)        All documents, cash, deposit accounts letters of credit, letter of credit rights, supporting
obligations, certificates of deposit, instruments, chattel paper, electronic chattel paper, tangible chattel paper and investment property, including, without limitation, all securities, whether certificated or uncertificated, security entitlements,
securities accounts, commodity contracts and commodity accounts, and all financial assets held in any securities account or otherwise, wherever located, now owned or hereafter acquired and Borrower’s books relating to the foregoing; and

 (f)        Any and all claims, rights and interests in any of the above and all substitutions
for, additions and accessions to and proceeds thereof, including, without limitation, insurance, condemnation, requisition or similar payments and the proceeds thereof. 
 Notwithstanding the foregoing, the Collateral shall not be deemed to include any equipment financed pursuant to the Security Agreement and Credit Agreement dated March 15, 2007 with Wells Fargo Bank, National
Association. 

  
 Notwithstanding the foregoing,
the Collateral shall not be deemed to include any copyrights, copyright applications, copyright registrations and like protection in each work of authorship and derivative work thereof, whether published or unpublished, now owned or hereafter
acquired; any patents, patent applications and like protections including without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same, trademarks, servicemarks and applications
therefor, whether registered or not, and the goodwill of the business of Borrower connected with and symbolized by such trademarks, any trade secret rights, including any rights to unpatented inventions, know-how, operating manuals, license rights
and agreements and confidential information, now owned or hereafter acquired; or any claims for damage by way of any past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”), except that the
Collateral shall include (A) the proceeds of all the Intellectual Property that are accounts, (i.e. accounts receivable) of Borrower, or general intangibles consisting of rights to payment, and (B) if a judicial authority (including a U.S.
Bankruptcy Court) holds that a security interest in the underlying Intellectual Property is necessary to have a security interest in such accounts and general intangibles of Borrower that are proceeds of the Intellectual Property, then the
Collateral shall automatically, and effective as of the date of Closing, include the Intellectual Property to the extent necessary to permit perfection of Agent’s security interest in such accounts and general intangibles of Borrower that are
proceeds of the Intellectual Property. 

  
 EXHIBIT C 

LANDLORD WAIVER 

_______________________ (“Landlord”) is the owner of real property commonly known as _________________________________________________ (the
“Premises”) and has leased the Premises to ACELRX PHARMACEUTICALS, INC. (“Tenant”). 
 Landlord acknowledges that it has
received notice that Tenant has or will enter into a Loan and Security Agreement (the “Loan Agreement”) with PINNACLE VENTURES L.L.C., as agent for certain Lenders (“Agent”), and the lenders party thereto (the
“Lenders”), whereby Tenant will grant to Agent a first priority security interest in certain equipment (the “Equipment”), all or part of which is currently or may be located upon or affixed to the Premises.

 Landlord agrees that Agent’s rights in the Equipment are superior to any right or claim which Landlord may have and waives and releases any and
all rights it may have against the Equipment for any rent or other sums due or to become due, under any lease for the Premises or otherwise, and all claims and demands of every kind against the Equipment. 

Landlord agrees that the Equipment will remain personal property and will not become part of the Premises, regardless of the manner in which it may be affixed to
real property, and will allow Agent or its agents to enter the Premises any time to remove the Equipment in the exercise of its rights and remedies arising under the Loan Agreement. 
 This Waiver shall be binding upon the heirs, administrators, executors, successors and assigns of the Landlord, and shall inure to the benefit of the successors and assigns of Agent and the Lenders. 

IN WITNESS WHEREOF, the undersigned has executed and delivered this Waiver this _____ day of _______________, 2008. 

 

			
	LANDLORD:
	
	 
		
	By:	 	 

			
		
	Name:	 	 

			
		
	Title:

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