Document:

EX-10.1

 Exhibit 10.1 

INDEMNITY AGREEMENT 
 This
Indemnity Agreement, dated as of                     ,
                     is made by and between Aeglea BioTherapeutics, Inc., a Delaware corporation (the
“Company”), and                     , a director, officer or key employee of the Company or one of the
Company’s subsidiaries or other service provider who satisfies the definition of Indemnifiable Person set forth below (“Indemnitee”). 

RECITALS 

A.        The Company is aware that competent and experienced persons are increasingly reluctant to
serve as representatives of corporations unless they are protected by comprehensive liability insurance and indemnification, due to increased exposure to litigation costs and risks resulting from their service to such corporations, and due to the
fact that the exposure frequently bears no relationship to the compensation of such representatives; 

B.        The members of the Board of Directors of the Company (the
“Board”) have concluded that to retain and attract talented and experienced individuals to serve as representatives of the Company and its Subsidiaries and Affiliates and to encourage such individuals to take the
business risks necessary for the success of the Company and its Subsidiaries and Affiliates, it is necessary for the Company to contractually indemnify certain of its representatives and the representatives of its Subsidiaries and Affiliates, and to
assume for itself maximum liability for Expenses and Other Liabilities in connection with claims against such representatives in connection with their service to the Company and its Subsidiaries and Affiliates; 

C.        Section 145 of the Delaware General Corporation Law (“Section
145”), empowers the Company to indemnify by agreement its officers, directors, employees and agents, and persons who serve, at the request of the Company, as directors, officers, employees or agents of other corporations,
partnerships, joint ventures, trusts or other enterprises, and expressly provides that the indemnification provided thereby is not exclusive; and 

D.        The Company desires and has requested Indemnitee to serve or continue to serve as a
representative of the Company and/or the Subsidiaries or Affiliates of the Company free from undue concern about inappropriate claims for damages arising out of or related to such services to the Company and/or the Subsidiaries or Affiliates of the
Company. 

 AGREEMENT 

NOW, THEREFORE, the parties hereto, intending to be legally bound, hereby agree as follows: 

1.        Definitions. 

(a) Affiliate. For purposes of this Agreement, “Affiliate” of the Company means any corporation, partnership,
limited liability company, joint venture, trust or other enterprise in respect of which Indemnitee is or was or will be serving as a director, officer, trustee, manager, member, partner, employee, agent, attorney, consultant, member of the
entity’s governing body (whether constituted as a board of directors, board of managers, general partner or otherwise), fiduciary, or in any other similar capacity at the request, election or direction of the Company, and including, but not
limited to, any employee benefit plan of the Company or a Subsidiary or Affiliate of the Company. 
 (b) Change in Control. For
purposes of this Agreement, “Change in Control” means (i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended), other than a
Subsidiary or a trustee or other fiduciary holding securities under an employee benefit plan of the Company or Subsidiary, is or becomes the “Beneficial Owner” (as defined in Rule 13d-3 under said Act), directly or
indirectly, of securities of the Company representing 50% or more of the total voting power represented by the Company’s then outstanding capital stock or (ii) during any period of two consecutive years, individuals who at the beginning of
such period constitute the Board and any new director whose election by the Board or nomination for election by the Company’s stockholders was approved by a vote of at least two-thirds (2/3) of the directors then still in office who either
were directors at the beginning of the period or whose election or nomination for election was previously so approved, cease for any reason to constitute a majority thereof, or (iii) the stockholders of the Company approve a merger or
consolidation of the Company with any other corporation, other than a merger or consolidation that would result in the outstanding capital stock of the Company outstanding immediately prior thereto continuing to represent (either by remaining
outstanding or by being converted into capital stock of the surviving entity) at least 80% of the total voting power represented by the capital stock of the Company or such surviving entity outstanding immediately after such merger or consolidation,
or the stockholders of the Company approve a plan of complete liquidation of the Company or an agreement for the sale or disposition by the Company (in one transaction or a series of transactions) of all or substantially all of the Company’s
assets. 
 (c) Expenses. For purposes of this Agreement, “Expenses” means all direct and indirect costs of any
type or nature whatsoever (including, without limitation, all attorneys’ fees and related disbursements, and other out-of-pocket costs), paid or incurred by Indemnitee in connection with either the investigation, defense or appeal of, or being
a witness in, a Proceeding (as defined below), or establishing or enforcing a right to indemnification under this Agreement, Section 145 or otherwise; provided, however, that Expenses shall not include any judgments, fines, ERISA excise taxes
or penalties or amounts paid in settlement of a Proceeding. 

 (d) Indemnifiable Event. For purposes of this Agreement, “Indemnifiable
Event” means any event or occurrence related to Indemnitee’s service for the Company or any Subsidiary or Affiliate as an Indemnifiable Person (as defined below), or by reason of anything done or not done, or any act or omission,
by Indemnitee in any such capacity. 
 (e) Indemnifiable Person. For the purposes of this Agreement, “Indemnifiable
Person” means any person who is or was a director, officer, trustee, manager, member, partner, employee, attorney, consultant, member of an entity’s governing body (whether constituted as a board of directors, board of managers,
general partner or otherwise) or other agent or fiduciary of the Company or a Subsidiary or Affiliate of the Company. 
 (f) Independent
Counsel. For purposes of this Agreement, “Independent Counsel” means legal counsel that has not performed services for the Company or Indemnitee in the five years preceding the time in question and that would not, under
applicable standards of professional conduct, have a conflict of interest in representing either the Company or Indemnitee. 
 (g)
Independent Director. For purposes of this Agreement, “Independent Director” means a member of the Board who is not a party to the Proceeding for which a claim is made under this Agreement. 

(h) Other Liabilities. For purposes of this Agreement, “Other Liabilities” means any and all liabilities of any
type whatsoever (including, but not limited to, judgments, fines, penalties, ERISA (or other benefit plan related) excise taxes or penalties, and amounts paid in settlement and all interest, taxes, assessments and other charges paid or payable in
connection with or in respect of any such judgments, fines, ERISA (or other benefit plan related) excise taxes or penalties, or amounts paid in settlement). 

(i) Proceeding. For the purposes of this Agreement, “Proceeding” means any threatened, pending, or completed
action, suit or other proceeding, whether civil, criminal, administrative, investigative, legislative or any other type whatsoever, preliminary, informal or formal, including any arbitration or other alternative dispute resolution and including any
appeal of any of the foregoing. 
 (j) Subsidiary. For purposes of this Agreement, “Subsidiary” means any
entity of which more than 50% of the outstanding voting securities is owned directly or indirectly by the Company. 

2.        Agreement to Serve. The Indemnitee agrees to serve and/or continue to serve as an
Indemnifiable Person in the capacity or capacities in which Indemnitee currently serves the Company as an Indemnifiable Person, and any additional capacity in which Indemnitee may agree to serve, until such time as Indemnitee’s service in a
particular capacity shall end according to the terms of an agreement, the Company’s Certificate of Incorporation or Bylaws, governing law, or otherwise. Nothing contained in this Agreement is intended to create any right to continued employment
or other form of service for the Company or a Subsidiary or Affiliate of the Company by Indemnitee. 

 3.        Mandatory Indemnification. 

(a) Agreement to Indemnify. In the event Indemnitee is a person who was or is a party to or witness in or is threatened to be made a
party to or witness in any Proceeding by reason of an Indemnifiable Event, the Company shall indemnify Indemnitee from and against any and all Expenses and Other Liabilities incurred by Indemnitee in connection with (including in preparation for)
such Proceeding to the fullest extent not prohibited by the provisions of the Company’s Bylaws and the Delaware General Corporation Law (“DGCL”), as the same may be amended from time to time (but only to the
extent that such amendment permits the Company to provide broader indemnification rights than the Bylaws or the DGCL permitted prior to the adoption of such amendment). 

(b) Exception for Amounts Covered by Insurance and Other Sources. Notwithstanding the foregoing, the Company shall not be obligated to
indemnify Indemnitee for Expenses or Other Liabilities of any type whatsoever (including, but not limited to judgments, fines, penalties, ERISA excise taxes or penalties and amounts paid in settlement) to the extent such have been paid directly to
Indemnitee (or paid directly to a third party on Indemnitee’s behalf) by any directors and officers, or other type, of insurance maintained by the Company or pursuant to other indemnity arrangements with third parties. 

(c) [WHERE SUCH DIRECTOR IS AFFILIATED WITH A VENTURE FUND OR SIMILAR SPONSORING ORGANIZATION] Company Obligations Primary. The
Company hereby acknowledges that Indemnitee may have rights to indemnification for Expenses and Other Liabilities provided by [name of VC or other sponsoring organization (“Other Indemnitor”)]. The Company agrees with
Indemnitee that the Company is the indemnitor of first resort of Indemnitee with respect to matters for which indemnification is provided under this Agreement and that the Company will be obligated to make all payments due to or for the benefit of
Indemnitee under this Agreement without regard to any rights that Indemnitee may have against the Other Indemnitor. The Company hereby waives any equitable rights to contribution or indemnification from the Other Indemnitor in respect of any amounts
paid to Indemnitee hereunder. The Company further agrees that no reimbursement of Other Liabilities or payment of Expenses by the Other Indemnitor to or for the benefit of Indemnitee shall affect the obligations of the Company hereunder, and that
the Company shall be obligated to repay the Other Indemnitor for all amounts so paid or reimbursed to the extent that the Company has an obligation to indemnify Indemnitee for such Expenses or Other Liabilities hereunder. 

4.        Partial Indemnification. If Indemnitee is entitled under any provision of this
Agreement to indemnification by the Company for some or a portion of any Expenses or Other Liabilities but not entitled, however, to indemnification for the total amount of such Expenses or Other Liabilities, the Company shall nevertheless indemnify
Indemnitee for such total amount except as to the portion thereof for which indemnification is prohibited by the provisions of the Company’s Bylaws or the DGCL. In any review or Proceeding to determine the extent of indemnification, the Company
shall bear the burden to establish, by clear and convincing evidence, the lack of a successful resolution of a particular claim, issue or matter and which amounts sought in indemnity are allocable to claims, issues or matters which were not
successfully resolved. 

 5.        Liability Insurance. So long as
Indemnitee shall continue to serve the Company or a Subsidiary or Affiliate of the Company as an Indemnifiable Person and thereafter so long as Indemnitee shall be subject to any possible claim or threatened, pending or completed Proceeding as a
result of an Indemnifiable Event, the Company shall use reasonable efforts to maintain in full force and effect for the benefit of Indemnitee as an insured (i) liability insurance issued by one or more reputable insurers and having the policy
amount and deductible deemed appropriate by the Board and providing in all respects coverage at least comparable to and in the same amount as that provided to the Chairman of the Board or the Chief Executive Officer of the Company and (ii) any
replacement or substitute policies issued by one or more reputable insurers providing in all respects coverage at least comparable to and in the same amount as that being provided to the Chairman of the Board or the Chief Executive Officer of the
Company. The purchase, establishment and maintenance of any such insurance or other arrangements shall not in any way limit or affect the rights and obligations of the Company or of Indemnitee under this Agreement except as expressly provided
herein, and the execution and delivery of this Agreement by the Company and Indemnitee shall not in any way limit or affect the rights and obligations of the Company or the other party or parties thereto under any such insurance or other
arrangement. In the event of a Change in Control subsequent to the date of this Agreement, or the Company’s becoming insolvent, including being placed into receivership or entering the federal bankruptcy process, the Company shall maintain in
force any directors’ and officers’ liability insurance policies then maintained by the Company in providing insurance in respect of Indemnitee, for a period of six years thereafter. 

6.        Mandatory Advancement of Expenses. If requested by Indemnitee, the Company shall
advance prior to the final disposition of the Proceeding all Expenses reasonably incurred by Indemnitee in connection with (including in preparation for) a Proceeding related to an Indemnifiable Event. Indemnitee hereby undertakes to repay such
amounts advanced if, and only if and to the extent that, it shall ultimately be determined that Indemnitee is not entitled to be indemnified by the Company under the provisions of this Agreement, the Company’s Bylaws or the DGCL, and no
additional form of undertaking with respect to such obligation to repay shall be required. The advances to be made hereunder shall be paid by the Company to Indemnitee or directly to a third party designated by Indemnitee within thirty
(30) days following delivery of a written request therefor by Indemnitee to the Company. Indemnitee’s undertaking to repay any Expenses advanced to Indemnitee hereunder shall be unsecured and shall not be subject to the accrual or payment
of any interest thereon. In the event that Indemnitee’s request for the advancement of expenses shall be accompanied by an affidavit of counsel to Indemnitee to the effect that such counsel has reviewed such Expenses and that such Expenses are
reasonable in such counsel’s view, then such expenses shall be deemed reasonable in the absence of clear and convincing evidence to the contrary. 

7.        Notice and Other Indemnification Procedures. 

(a) Notification. Promptly after receipt by Indemnitee of notice of the commencement of or the threat of commencement of any Proceeding,
Indemnitee shall, if Indemnitee believes that indemnification or advancement of Expenses with respect thereto may be sought from the Company under this Agreement, notify the Company of the commencement or threat of commencement thereof. However, a
failure so to notify the Company promptly following Indemnitee’s receipt of such notice shall not relieve the Company from any liability that it may have to Indemnitee except to the extent that the Company is materially prejudiced in its
defense of such Proceeding as a result of such failure. 

 (b) Insurance and Other Matters. If, at the time of the receipt of a notice of the
commencement of a Proceeding pursuant to Section 7(a) above, the Company has director and officer liability insurance in effect, the Company shall give prompt notice of the commencement of such Proceeding to the issuers in accordance with the
procedures set forth in the respective policies. The Company shall thereafter take all reasonable action to cause such insurers to pay, on behalf of Indemnitee, all amounts payable as a result of such Proceeding in accordance with the terms of such
insurance policies. 
 (c) Assumption of Defense. In the event the Company shall be obligated to advance the Expenses for any
Proceeding against Indemnitee, the Company, if deemed appropriate by the Company, shall be entitled to assume the defense of such Proceeding as provided herein. Such defense by the Company may include the representation of two or more parties by one
attorney or law firm as permitted under the ethical rules and legal requirements related to joint representations. Following delivery of written notice to Indemnitee of the Company’s election to assume the defense of such Proceeding, the
approval by Indemnitee (which approval shall not be unreasonably withheld) of counsel designated by the Company and the retention of such counsel by the Company, the Company will not be liable to Indemnitee under this Agreement for any fees and
expenses of counsel subsequently incurred by Indemnitee with respect to the same Proceeding. If (A) the employment of counsel by Indemnitee has been previously authorized by the Company, (B) Indemnitee shall have notified the Board in
writing that Indemnitee has reasonably concluded that there is likely to be a conflict of interest between the Company and Indemnitee in the conduct of any such defense, or (C) the Company fails to employ counsel to assume the defense of such
Proceeding, the fees and expenses of Indemnitee’s counsel shall be subject to indemnification and/or advancement pursuant to the terms of this Agreement. Nothing herein shall prevent Indemnitee from employing counsel for any such Proceeding at
Indemnitee’s expense. 
 (d) Settlement. The Company shall not be liable to indemnify Indemnitee under this Agreement or
otherwise for any amounts paid in settlement of any Proceeding effected without the Company’s written consent; provided, however, that if a Change in Control has occurred subsequent to the date of this Agreement, the Company shall be liable for
indemnification of Indemnitee for amounts paid in settlement if the Independent Counsel has approved the settlement. Neither the Company nor any Subsidiary or Affiliate shall enter into a settlement of any Proceeding that might result in the
imposition of any Expense, Other Liability, penalty, limitation or detriment on Indemnitee, whether indemnifiable under this Agreement or otherwise, without Indemnitee’s written consent. Neither the Company nor Indemnitee shall unreasonably
withhold consent from any settlement of any Proceeding. The Company shall promptly notify Indemnitee upon the Company’s receipt of an offer to settle, or if the Company makes an offer to settle, any Proceeding, and provide Indemnitee with a
reasonable amount of time to consider such settlement, in the case of any such settlement for which the consent of Indemnitee would be required hereunder. The Company shall not, on its own behalf, settle any part of any Proceeding to which
Indemnitee is a party with respect to other parties (including the Company) without the written consent of Indemnitee if any portion of the settlement is to be funded from insurance proceeds unless approved by a majority of the Independent
Directors, 

 
provided that this sentence shall cease to be of any force and effect if it has been determined in accordance with this Agreement that Indemnitee is not entitled to indemnification hereunder with
respect to such Proceeding or if the Company’s obligations hereunder to Indemnitee with respect to such Proceeding have been fully discharged. 

8.        Determination of Right to Indemnification. 

(a) Success on the Merits or Otherwise. To the extent that Indemnitee has been successful on the merits or otherwise in defense of any
Proceeding referred to in Section 3(a) above or in the defense of any claim, issue or matter described therein, the Company shall indemnify Indemnitee against Expenses actually and reasonably incurred in connection therewith. 

(b) Indemnification in Other Situations. In the event that Section 8(a) is inapplicable, the Company shall also indemnify
Indemnitee if Indemnitee has not failed to meet the applicable standard of conduct for indemnification. 
 (c) Forum. Indemnitee shall
be entitled to select the forum in which determination of whether or not Indemnitee has met the applicable standard of conduct shall be decided, and such election will be made from among the following: 

(1) Those members of the Board who are Independent Directors even though less than a quorum; 

(2) A committee of Independent Directors designated by a majority vote of Independent Directors, even though less than a quorum; or 

(3) Independent Counsel selected by Indemnitee and approved by the Board, which approval may not be unreasonably withheld, which counsel shall
make such determination in a written opinion. 
 If Indemnitee is an officer or a director of the Company at the time that Indemnitee is
selecting the forum, then Indemnitee shall not select Independent Counsel as such forum unless there are no Independent Directors or unless the Independent Directors agree to the selection of Independent Counsel as the forum. 

The selected forum shall be referred to herein as the “Reviewing Party”. Notwithstanding the foregoing, following any Change in Control
subsequent to the date of this Agreement, the Reviewing Party shall be Independent Counsel selected in the manner provided in c. above. 

(d) Decision Timing and Expenses. As soon as practicable, and in no event later than thirty (30) days after receipt by the Company
of written notice of Indemnitee’s choice of forum pursuant to Section 8(c) above, the Company and Indemnitee shall each submit to the Reviewing Party such information as they believe is appropriate for the Reviewing Party to consider. The
Reviewing Party shall arrive at its decision within a reasonable period of time following the receipt of all such information from the Company and Indemnitee, but in no event later than thirty (30) days following the receipt of all such
information, provided that the time by which the Reviewing Party must reach a decision may be extended by mutual agreement of the Company and Indemnitee. All Expenses associated with the process set forth in this Section 8(d), including but not
limited to the Expenses of the Reviewing Party, shall be paid by the Company. 

 (e) Delaware Court of Chancery. Notwithstanding a final determination by any Reviewing
Party that Indemnitee is not entitled to indemnification with respect to a specific Proceeding, Indemnitee shall have the right to apply to the Court of Chancery, for the purpose of enforcing Indemnitee’s right to indemnification pursuant to
this Agreement. 
 (f) Expenses. The Company shall indemnify Indemnitee against all Expenses incurred by Indemnitee in connection with
any hearing or Proceeding under this Section 8 involving Indemnitee and against all Expenses and Other Liabilities incurred by Indemnitee in connection with any other Proceeding between the Company and Indemnitee involving the interpretation or
enforcement of the rights of Indemnitee under this Agreement unless a court of competent jurisdiction finds that each of the material claims of Indemnitee in any such Proceeding was frivolous or made in bad faith. 

(g) Determination of “Good Faith”. For purposes of any determination of whether Indemnitee acted in “good
faith”, Indemnitee shall be deemed to have acted in good faith if in taking or failing to take the action in question Indemnitee relied on the records or books of account of the Company or a Subsidiary or Affiliate, including financial
statements, or on information, opinions, reports or statements provided to Indemnitee by the officers or other employees of the Company or a Subsidiary or Affiliate in the course of their duties, or on the advice of legal counsel for the Company or
a Subsidiary or Affiliate, or on information or records given or reports made to the Company or a Subsidiary or Affiliate by an independent certified public accountant or by an appraiser or other expert selected by the Company or a Subsidiary or
Affiliate, or by any other person (including legal counsel, accountants and financial advisors) as to matters Indemnitee reasonably believes are within such other person’s professional or expert competence and who has been selected with
reasonable care by or on behalf of the Company or a Subsidiary or Affiliate. In connection with any determination as to whether Indemnitee is entitled to be indemnified hereunder, or to advancement of expenses, the Reviewing Party or court shall
presume that Indemnitee has satisfied the applicable standard of conduct and is entitled to indemnification or advancement of Expenses, as the case may be, and the burden of proof shall be on the Company to establish, by clear and convincing
evidence, that Indemnitee is not so entitled. The provisions of this Section 8(g) shall not be deemed to be exclusive or to limit in any way the other circumstances in which Indemnitee may be deemed to have met the applicable standard of
conduct set forth in this Agreement. In addition, the knowledge and/or actions, or failures to act, of any other person serving the Company or a Subsidiary or Affiliate as an Indemnifiable Person shall not be imputed to Indemnitee for purposes of
determining the right to indemnification hereunder. 
 9.        Exceptions. Any other
provision herein to the contrary notwithstanding, 
 (a) Claims Initiated by Indemnitee. The Company shall not be obligated pursuant
to the terms of this Agreement to indemnify or advance Expenses to Indemnitee with respect to Proceedings or claims initiated or brought voluntarily by Indemnitee and not by way of defense, except (1) with respect to Proceedings brought to
establish or enforce a right to 

 
indemnification under this Agreement, any other statute or law, as permitted under Section 145, or otherwise, (2) where the Board has consented to the initiation of such Proceeding, or
(3) with respect to Proceedings brought to discharge Indemnitee’s fiduciary responsibilities, whether under ERISA or otherwise, but such indemnification or advancement of Expenses may be provided by the Company in specific cases if the
Board finds it to be appropriate; or 
 (b) Actions Based on Federal Statutes Regarding Profit Recovery and Return of Bonus Payments.
The Company shall not be obligated pursuant to the terms of this Agreement to indemnify Indemnitee on account of (i) any suit in which judgment is rendered against Indemnitee for an accounting of profits made from the purchase or sale by
Indemnitee of securities of the Company pursuant to the provisions of Section 16(b) of the Securities Exchange Act of l934 and amendments thereto or similar provisions of any federal, state or local statutory law, or (ii) any reimbursement
of the Company by the Indemnitee of any bonus or other incentive-based or equity-based compensation or of any profits realized by the Indemnitee from the sale of securities of the Company, as required in each case under the Exchange Act (including
any such reimbursements that arise from an accounting restatement of the Company pursuant to Section 304 of the Sarbanes-Oxley Act of 2002 (the “Sarbanes-Oxley Act”), or the payment to the Company of profits arising from
the purchase and sale by Indemnitee of securities in violation of Section 306 of the Sarbanes-Oxley Act); or 
 (c) Unlawful
Indemnification. The Company shall not be obligated pursuant to the terms of this Agreement to indemnify Indemnitee for Other Liabilities if such indemnification is prohibited by law as determined by a court of competent jurisdiction in a final
adjudication not subject to further appeal. 
 10.        Non-exclusivity. The provisions for
indemnification and advancement of Expenses set forth in this Agreement shall not be deemed exclusive of any other rights which Indemnitee may have under any provision of law, the Company’s Certificate of Incorporation or Bylaws, the vote of
the Company’s stockholders or disinterested directors, other agreements, or otherwise, both as to acts or omissions in his or her official capacity and to acts or omissions in another capacity while serving the Company or a Subsidiary or
Affiliate as an Indemnifiable Person and Indemnitee’s rights hereunder shall continue after Indemnitee has ceased serving the Company or a Subsidiary or Affiliate as an Indemnifiable Person and shall inure to the benefit of the heirs, executors
and administrators of Indemnitee. 
 11.        Severability. If any provision or provisions
of this Agreement shall be held to be invalid, illegal or unenforceable for any reason whatsoever, (i) the validity, legality and enforceability of the remaining provisions of the Agreement (including, without limitation, all portions of any
paragraphs of this Agreement containing any such provision held to be invalid, illegal or unenforceable, that are not themselves invalid, illegal or unenforceable) shall not in any way be affected or impaired thereby, and (ii) to the fullest
extent possible, the provisions of this Agreement (including, without limitation, all portions of any paragraphs of this Agreement containing any such provision held to be invalid, illegal or unenforceable, that are not themselves invalid, illegal
or unenforceable) shall be construed so as to give effect to the intent manifested by the provision held invalid, illegal or unenforceable. 

 12.        Supersession, Modification and Waiver.
This Agreement supersedes any prior indemnification agreement between the Indemnitee and the Company, its Subsidiaries or its Affiliates. If the Company and Indemnitee have previously entered into an indemnification agreement providing for the
indemnification of Indemnitee by the Company, parties entry into this Agreement shall be deemed to amend and restate such prior agreement to read in its entirety as, and be superseded by, this Agreement. No supplement, modification or amendment of
this Agreement shall be binding unless executed in writing by both of the parties hereto. No waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any other provision hereof (whether or not similar) and
except as expressly provided herein, no such waiver shall constitute a continuing waiver. 

13.        Successors and Assigns. The terms of this Agreement shall bind, and shall inure to
the benefit of, the successors and assigns of the parties hereto. 
 14.        Notice. All
notices, requests, demands and other communications under this Agreement shall be in writing and shall be deemed duly given (i) if delivered by hand and a receipt is provided by the party to whom such communication is delivered, (ii) if
mailed by certified or registered mail with postage prepaid, return receipt requested, on the signing by the recipient of an acknowledgement of receipt form accompanying delivery through the U.S. mail, (iii) personal service by a process
server, or (iv) delivery to the recipient’s address by overnight delivery (e.g., FedEx, UPS or DHL) or other commercial delivery service. Addresses for notice to either party are as shown on the signature page of this Agreement, or as
subsequently modified by written notice complying with the provisions of this Section 14. Delivery of communications to the Company with respect to this Agreement shall be sent to the attention of the Company’s Vice President of Finance.

 15.        No Presumptions. For purposes of this Agreement, the termination of any
Proceeding, by judgment, order, settlement (whether with or without court approval) or conviction, or upon a plea of nolo contendere or its equivalent, shall not, of itself, create a presumption that Indemnitee did not meet any particular standard
of conduct or have any particular belief or that a court has determined that indemnification is not permitted by applicable law or otherwise. In addition, neither the failure of the Company or a Reviewing Party to have made a determination as to
whether Indemnitee has met any particular standard of conduct or had any particular belief, nor an actual determination by the Company, or a Reviewing Party that Indemnitee has not met such standard of conduct or did not have such belief, prior to
the commencement of Proceedings by Indemnitee to secure a judicial determination by exercising Indemnitee’s rights under Section 8(e) of this Agreement shall be a defense to Indemnitee’s claim or create a presumption that Indemnitee
has failed to meet any particular standard of conduct or did not have any particular belief or is not entitled to indemnification under applicable law or otherwise. 

16.        Survival of Rights. The rights conferred on Indemnitee by this Agreement shall
continue after Indemnitee has ceased to serve the Company or a Subsidiary or Affiliate of the Company as an Indemnifiable Person and shall inure to the benefit of Indemnitee’s heirs, executors and administrators. 

 17.        Subrogation and Contribution. 

(a) [Except as otherwise expressly provided in this Agreement, i]1/[I]n the event of
payment under this Agreement, the Company shall be subrogated to the extent of such payment to all of the rights of recovery of Indemnitee, who shall execute all documents required and shall do all acts that may be necessary to secure such rights
and to enable the Company effectively to bring suit to enforce such rights. 
 (b) To the fullest extent permissible under applicable law, if
the indemnification provided for in this Agreement is unavailable to Indemnitee for any reason whatsoever, the Company, in lieu of indemnifying Indemnitee, shall contribute to the amount incurred by or on behalf of Indemnitee, whether for judgments,
fines, penalties, excise taxes, amounts paid or to be paid in settlement and/or for Expenses, in connection with any claim relating to an indemnifiable event under this Agreement, in such proportion as is deemed fair and reasonable in light of all
of the circumstances of such Proceeding in order to reflect (i) the relative benefits received by the Company and Indemnitee as a result of the event(s) and/or transaction(s) giving cause to such Proceeding; and/or (ii) the relative fault
of the Company (and its directors, officers, employees and agents) and Indemnitee in connection with such event(s) and/or transaction(s). 

18.        Specific Performance, Etc. The parties recognize that if any provision of this
Agreement is violated by the Company, Indemnitee may be without an adequate remedy at law. Accordingly, in the event of any such violation, Indemnitee shall be entitled, if Indemnitee so elects, to institute Proceedings, either in law or at equity,
to obtain damages, to enforce specific performance, to enjoin such violation, or to obtain any relief or any combination of the foregoing as Indemnitee may elect to pursue. 

19.        Counterparts. This Agreement may be executed in counterparts, each of which shall
for all purposes be deemed to be an original but all of which together shall constitute one and the same agreement. Only one such counterpart signed by the party against whom enforceability is sought needs to be produced to evidence the existence of
this Agreement. 
 20.        Headings. The headings of the sections and paragraphs of this
Agreement are inserted for convenience only and shall not be deemed to constitute part of this Agreement or to affect the construction or interpretation thereof. 

21.        Governing Law. This Agreement shall be governed exclusively by and construed
according to the laws of the State of Delaware, as applied to contracts between Delaware residents entered into and to be performed entirely with Delaware. 

22.        Consent to Jurisdiction. The Company and Indemnitee each hereby irrevocably consent
to the jurisdiction of the courts of the State of Delaware for all purposes in connection with any Proceeding which arises out of or relates to this Agreement. 

 

	1 	NTD: Include if Section 3(c) is included above. 

 The parties hereto have entered into this Indemnity Agreement effective as of the date first
above written. 
  

							
			AEGLEA BIOTHERAPEUTICS, INC.
			
			By:		 
			Its:		 
			
			INDEMNITEE:		 
		
			 
		
	Address:EX-10.6

 Exhibit 10.6 

EXECUTIVE EMPLOYMENT AGREEMENT 

This EXECUTIVE EMPLOYMENT AGREEMENT (this “Agreement”), is made and entered into as of July 7, 2015 (the “Effective
Date”), by and between Aeglea Development Company, Inc., a Delaware corporation (the “Company”) and David G. Lowe (“Executive”). 

W I T N E S S E T H 

WHEREAS, the Company is one of several wholly-owned subsidiaries (the “Subsidiaries”) of Aeglea BioTherapeutics, Inc.
(“Parent” and together with the Subsidiaries, and any future subsidiaries of the Parent, the “Group”); 
 WHEREAS, the
Company desires to continue Executive’s employment as its Chief Executive Officer (“CEO”), and to enter into this Agreement with Executive embodying the terms of such employment; 

WHEREAS, Executive desires to be employed by the Company as CEO, and to enter into this Agreement; 

WHEREAS, Executive will also serve as CEO to the Parent and to each of the Subsidiaries; 

WHEREAS, the Company wishes to protect its investment in its business, employees, customer relationships, and confidential information, by
requiring Executive to abide by certain restrictive covenants regarding confidentiality and other matters, each of which is an inducement to the Company to employ Executive; 

NOW, THEREFORE, in consideration of the mutual promises herein contained, and other good and valuable consideration, including the employment
of Executive by the Company and the compensation received by Executive from the Company from time to time, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as follows: 

1.        EMPLOYMENT. The Company agrees to employ Executive as its CEO, reporting to the
Company’s Board of Directors (“Board”), and Executive agrees to accept such employment upon the terms and conditions hereinafter set forth. So long as Executive is employed by the Company as CEO pursuant to this Agreement, Executive
will serve as a member of the Board, subject to any required Board and/or security holder approval. The parties understand and agree that although the Company will, pursuant to this Agreement, employ Executive, maintain Executive’s employment
records, pay his cash compensation and provide his benefits during the Term, the Company will also arrange with the Parent and the Subsidiaries for Executive to-serve as CEO to (but not as an employee of) the Parent and to each of the Subsidiaries
during the Term. 
 2.         AT-WILL EMPLOYMENT. The parties agree that Executive’s
employment with the Company will be “at-will” employment and may be terminated at any time with or without cause or notice. Executive understands and agrees that neither his job performance nor promotions, commendations, bonuses or the
like from the Company give rise to or in any way 

 
serve as the basis for modification, amendment, or extension, by implication or otherwise, of his employment with the Company. However, as described in Section 6 of this Agreement, Executive may
be entitled to severance benefits depending on the circumstances of Executive’s termination of employment with the Company. The period of Executive’s employment under this Agreement is referred to herein as the “Term.” 

3.         DUTIES AND SERVICE. During the Term, except as permitted below in this Section 3,
Executive will devote his full business time and attention to the business and affairs of the Company. Executive will faithfully discharge his responsibilities and perform all duties of the position of CEO, including those duties, if any, as are
reasonably prescribed to him from time to time by the Board. Executive will fulfill his duties and responsibilities in an adequate, reasonable and appropriate manner in compliance with the Company’s policies and practices, and the laws and
regulations that apply to the Company’s operation and administration. For purposes of clarification, Executive understands and agrees that, except as set forth on Exhibit A or as otherwise approved in writing by the Board (which approval will
not be unreasonably withheld or delayed), in addition to any other outside business activities or services, Executive may not engage in the following activities during the Term: (i) service on boards, committees or similar bodies of for-profit
entities and/or charitable, civic or other nonprofit organizations, (ii) teaching, speaking and writing engagements and/or (iii) attending educational seminars and programs; provided, however, that investment in entities in which (x) Executive does
not serve as a director, officer or employee of such entity and (y) if such entity has publicly traded securities, Executive owns less than five percent (5%) of the outstanding stock of such entity, will not by itself be deemed to be a violation of
this provision; provided, further, that any activities permitted in accordance with this provision do not compete with the Business (as defined below) of the Group or interfere or conflict in any material respect with the performance of
Executive’s duties and responsibilities under this Agreement. 
 4.
        COMPENSATION. During the Term, Executive’s compensation will be determined and paid as follows: 

(a)         BASE SALARY. The Company will pay Executive as compensation an annual base salary
of Three Hundred Eighty-Two Thousand Five Hundred Dollars ($382,500.00) (minus any federal, state and local payroll taxes and other withholdings legally required or properly requested by Executive) (the “Base Salary”) on the Company’s
regularly scheduled paydays (but not less than monthly) in accordance with the Company’s payroll practices and procedures. Executive’s Base Salary will be subject to periodic review by the Board and may be increased from time to time as
well as decreased, subject to Section 4(d). 
 (b)         ANNUAL BONUS. The Company may pay
to Executive a discretionary bonus of up to thirty-five percent (35%) of Executive’s Base Salary (the “Annual Bonus”). The actual amount of such Annual Bonus will be determined by the Board (or a committee of the Board) in its sole
discretion. Executive’s receipt of the Annual Bonus shall be conditioned upon Executive’s achievement of performance objectives set by the Board in writing after consultation with Executive in the applicable calendar year, beginning with
calendar year 2015. The Board will determine in its sole discretion whether such performance objectives have been achieved. The Annual Bonus for any given year will be payable between January 1 and March 15 in the year immediately following the year
to which the performance relates. Except for 2015, Executive will not be eligible to receive an Annual Bonus for any other partial year of 

  
 2 

 
employment. Accordingly, Executive forfeits any Annual Bonus for which Executive might otherwise be eligible if Executive’s employment ends for any reason before the final day of the bonus
year. For purposes of clarification, nothing herein guarantees Executive’s receipt of an Annual Bonus in any amount if the performance objectives are not met, any of the other conditions set forth herein are not satisfied in a given calendar
year, or the Company does not have sufficient funding to allow for the payment of bonuses. 
 (c)
        ACCELERATED VESTING. Executive’s rights to acceleration of vesting of equity awards shall be governed by the Severance Agreement between Executive and the Company or its Parent. 

(d)         BENEFITS. Executive will (subject to applicable eligibility requirements) receive
such other benefits as are provided from time to time to other senior executives of the Company pursuant to the Company’s (or Parent’s or Subsidiary’s, as applicable) policies and procedures as they may be instituted from time to
time. All such benefits are subject to the provisions of their respective plan documents in accordance with their terms. Executive acknowledges and agrees that the Company has the unilateral right to amend, modify or terminate its employee benefit
plans or policies at any time during the Term, with or without prior notice, subject to the requirement that Executive will not be provided with employee benefits that are inferior to the employee benefits available to any other senior executive of
the Group. 
 (e)         VACATION. Executive will be entitled to take and accrue up to four
weeks annual vacation or paid time off or such greater amount of time as the Company may provide for senior executives pursuant to the Company’s vacation or paid time off policies and procedures as they may be instituted from time to time. Such
vacation or paid time off will accrue in accordance with the Company’s then-existing policies, or monthly in the absence of any policies. Unless otherwise provided by the Company’s vacation policy, accrued, unused vacation will not roll
over from one calendar year to the next, and the Company will not payout unused, accrued vacation. In addition, Executive will forfeit payment for any accrued but unused paid vacation time upon termination. 

5.         TERMINATION. Executive’s employment hereunder may be terminated as follows:

 (a)         TERMINATION UPON DEATH OR DISABILITY. Executive’s employment will
automatically terminate in the event of Executive’s death on the date of his death or in the event of the Disability of Executive. For purposes of this Agreement, the term “Disability” will mean that Executive is unable to perform the
essential functions of his job by reason of illness, physical or mental disability or other incapacity, with or without a reasonable accommodation for more than ninety (90) days (which need not be consecutive) within any twelve (12) month period;
provided, however, nothing herein will give the Company the right to terminate Executive prior to discharging its obligations to Executive, if any, under the Family and Medical Leave Act, the Americans with Disabilities Act, or any other applicable
law. 
 (b)         TERMINATION. Subject to the provisions of Section 6, below, the Company
may terminate Executive’s employment at any time with or without Cause upon written notice to Executive and Executive may resign his employment at any time upon written notice to Company. 

  
 3 

 (c)         RESIGNATION AS OFFICER AND DIRECTOR.
Upon termination of Executive’s employment by either party for any reason, Executive will resign his position(s), if any, as an officer or director of the Company, as a member of any Board committees, as well as any other positions he may hold
with or for the benefit of the Company and/or its affiliates, including his position as CEO of the Parent and any of the Subsidiaries. 
 6.
        PAYMENT OBLIGATIONS UPON TERMINATION. 
 (a)
        ACCRUED COMPENSATION AND BENEFITS. Upon termination of Executive’s employment by either party regardless of the cause or reason, Executive will be entitled to: (i) payment for any accrued,
unpaid Base Salary through the termination date; and (ii) reimbursement for any approved business expenses that Executive has timely submitted for reimbursement in accordance with the Company’s business expense reimbursement policy or
practice. 
 (b)         SEVERANCE. Executive’s rights to severance benefits shall be
governed by the Severance Agreement between Executive and the Company or its Parent. 
 7.
        CODE SECTION 409A. 
 (a)         If
Executive is a “specified employee” of the Company (or any successor entity thereto) within the meaning of Section 409A on the date of Executive’s termination of employment (other than a termination of employment due to death), then
the Deferred Payments that are payable within the first six (6) months following Executive’s termination of employment, will be delayed until the first payroll date that occurs on or after the date that is six (6) months and one (1) day after
the date of Executive’s termination of employment, when they will be paid in full arrears. All subsequent Deferred Payments, if any, will be paid in accordance with the payment schedule applicable to each payment or benefit. Notwithstanding
anything herein to the contrary, if Executive dies following Executive’s employment termination but prior to the six (6) month anniversary of his employment termination, then any payments delayed in accordance with this paragraph will be
payable in a lump sum as soon as administratively practicable after the date of death and all other Deferred Payments will be payable in accordance with the payment schedule applicable to each payment or benefit. Each payment and benefit payable
under this Agreement is intended to constitute a separate payment for purposes of Section 1.409A-2(b)(2) of the Treasury Regulations. For the purposes of this Agreement, “Deferred Payment” means any severance pay or benefits to be paid or
provided to Executive (or Executive’s estate or beneficiaries) pursuant to this Agreement and any other severance payments or separation benefits, that in each case, when considered together, are considered deferred compensation under Section
409A. 
 (b)         Any ambiguities or ambiguous terms herein will be interpreted to be exempt from
or comply with the requirements of Section 409A. The Company and Executive agree to work together in good faith to consider amendments to this Agreement and to take such reasonable actions which are necessary, appropriate or desirable to avoid
imposition of any additional tax or income recognition prior to actual payment to Executive under Section 409A. 

  
 4 

 8.         [Intentionally blank] 

9.         RETURN OF PROPERTY. Upon the termination of Executive’s employment with the
Company for any reason, Executive will return to the Company all personal property belonging to the Company, Parent and its Subsidiaries (the “Company Property”) that is in Executive’s possession or control as of the date of such
termination of employment, including, without limitation, all records, papers, drawings, notebooks, marketing materials, software, reports, proposals, equipment, or any other device, document or possession, however obtained. Such Company Property
will be returned in the same condition as when provided to Executive, reasonable wear and tear excepted. 
 10.
        CONFIDENTIAL INFORMATION. 
 (a)
        Executive acknowledges that the Company will give Executive access to certain highly-sensitive, confidential, and proprietary information belonging to the Company, Parent and its Subsidiaries or third
parties who may have furnished such information under obligations of confidentiality, relating to and used in the Company’s business (collectively, “Confidential Information”). Executive acknowledges that, unless otherwise available
to the public, Confidential Information includes, but is not limited to, the following categories of Company-related confidential or proprietary information and material, whether in electronic, print, or other form, including all copies, notes, or
other reproductions or replicas thereof: financial statements and information; budgets, forecasts, and projections; business and strategic plans; marketing, sales, and distribution strategies; research and development projects; records relating to
any intellectual property developed by, owned by, controlled, or maintained by the Company; information related to the Company’s inventions, research, products, designs, methods, formulae, techniques, systems, processes; Biological Materials;
customer lists; non-public information relating to the Company’s customers, suppliers, distributors, or investors; the specific terms of the Company’s agreements or arrangements, whether oral or written, with any customer, supplier,
vendor, or contractor with which the Company may be associated from time to time; and any and all information relating to the operation of the Company’s business which the Company may from time to time designate as confidential or proprietary
or that Executive reasonably knows should be, or has been, treated by the Company as confidential or proprietary. As used in this Agreement, the term “Biological Materials” means all chemical or biological materials of any kind, including,
without limitation, any and all reagents, substances, chemical compounds, proteins or derivatives thereof, subcellular constituents, cells or cell lines, tissue samples, organisms and progeny, mutants, derivatives or replications thereof or
therefrom. 
 (b)         Any trade secrets of the Company, Parent or its Subsidiaries will be
entitled to all of the protections and benefits under any applicable law. If any information that the Company deems to be a trade secret is found by a court of competent jurisdiction not to be a trade secret, such information will, nevertheless, be
considered Confidential Information for purposes of this Agreement. 
 (c)         Confidential
Information does not include any information that: (i) at the time of disclosure is generally known to, or readily ascertainable by, the public; (ii) becomes known to the public through no fault of Executive or other violation of this Agreement; or
(iii) is disclosed to Executive by a third party under no obligation to maintain the confidentiality of the information. 

  
 5 

 (d)         Executive acknowledges that the Confidential
Information is owned or licensed by the Company; is unique, valuable, proprietary and confidential; and derives independent actual or potential commercial value from not being generally known or available to the public. Executive hereby
relinquishes, and agrees that he will not at any time claim, any right, title or interest of any kind in or to any Confidential Information. 

(e)         During and after his employment with the Company, Executive will hold in trust and
confidence all Confidential Information, and will not disclose any Confidential Information to any person or entity, except in the course of performing duties assigned by the Company or as authorized in writing by the Company. Executive further
agrees that during and after his employment with the Company, Executive will not use any Confidential Information for the benefit of any third party, except in the course of performing duties assigned by the Company or as authorized in writing by
the Company. 
 (f)         The restriction in Subsection 10(e) above will not apply to any
information that Executive is required to disclose by law, provided that Executive (i) notifies the Company of the existence and terms of such obligation, (ii) gives the Company a reasonable opportunity to seek a protective or similar order to
prevent or limit such disclosure, and (iii) only discloses that information actually required to be disclosed. 
 11.
        ASSIGNMENT OF INVENTIONS. 
 (a)
        Executive agrees that all developments or inventions (including without limitation any and all software programs (source and object code), algorithms and applications, concepts, designs, discoveries,
improvements, processes, techniques, know-how and data) that result from work performed by Executive for the Company, whether or not patentable or registrable under copyright or similar statutes or subject to analogous protection
(“Inventions”), will be the sole and exclusive property of the Company or its nominees, and Executive will and hereby does assign to the Company all rights in and to such Inventions upon the creation of any such Invention, including,
without limitation: (i) patents, patent applications and patent rights throughout the world; (ii) rights associated with works of authorship throughout the world, including copyrights, copyright applications, copyright registrations, mask work
rights, mask work applications and mask work registrations; (iii) rights relating to the protection of trade secrets and confidential information throughout the world; (iv) rights analogous to those set forth herein and any other proprietary rights
relating to intangible property; and (v) divisions, continuations, renewals, reissues and extensions of the foregoing (as applicable), now existing or hereafter filed, issued or acquired (collectively, the “IP Rights”). For avoidance of
doubt, all references to the “Company” in this Section 11(a) shall be deemed to include the Company, Parent and all of the Subsidiaries for which Executive serves as CEO. 

(b)         For avoidance of doubt, if any Inventions fall within the definition of “work made
for hire”, as such term is defined in 17 U.S.C. § 101, such Inventions will be considered “work made for hire” and the copyright of such Inventions will be owned solely and exclusively by the Company. If any Inventions do not
fall within such definition of “work made for hire”, then Executive’s right, title and interest in and to such Inventions will be assigned to the Company pursuant to Subsection 11(a) above. 

  
 6 

 (c)         The Company and its nominees will have the
right to use and/or to apply for statutory or common law protections for such Inventions in any and all countries. Executive further agrees, at the Company’s expense, to: (i) reasonably assist the Company in obtaining and from time to time
enforcing such IP Rights relating to Inventions, and (ii) execute and deliver to the Company or its nominee upon reasonable request all such documents as the Company or its nominee may reasonably determine are necessary or appropriate to effect the
purposes of this Section 11, including assignments of inventions. Such documents may be necessary to: (1) vest in the Company or its nominee clear and marketable title in and to Inventions; (2) apply for, prosecute and obtain patents, copyrights,
mask works rights and other rights and protections relating to Inventions; or (3) enforce patents, copyrights, mask works rights and other rights and protections relating to Inventions. Executive’s obligations pursuant to this Section 11 will
continue beyond the termination of Executive’s employment with the Company. If the Company is unable for any reason to secure Executive’s signature to any lawful and necessary document required to apply for or execute any patent,
trademark, copyright or other applications with respect to any Inventions (including renewals, extensions, continuations, divisions or continuations in part thereof), Executive hereby irrevocably designates and appoints the Company and its then
current Chief Executive Officer as Executive’s agent and attorney-in-fact to act for and in behalf and instead of Executive, to execute and file any such application and to do all other lawfully permitted acts to further the prosecution and
issuance of patents, trademarks, copyrights or other rights thereon with the same legal force and effect as if executed by Executive. In the event the Company utilizes the power of attorney set forth in the preceding sentence, the Company will
provide Executive with written notice of the terms and circumstances of such utilization within thirty (30) days following such utilization. 

12.         RESTRICTIVE COVENANTS. 

(a)         ACKNOWLEDGMENT. Executive acknowledges that during the course of his employment
with the Company, (i) Executive will have access to trade secrets and other Confidential Information of the Company, Parent and the Subsidiaries, which, if disclosed (or used intentionally or subconsciously), could unfairly and inappropriately
assist in competition against the Company, Parent and/or any of the Subsidiaries and (ii) in the course of his employment by a competitor during the Restricted Period (as defined below), Executive would inevitably use or disclose such trade secrets
and Confidential Information. Therefore, Executive agrees that the restrictions set forth in Sections 12(b) and 12(c) following on activities during and after Executive’s employment are necessary, appropriate and reasonable to protect the
goodwill, Confidential Information and other legitimate interests of the Company, Parent and the Subsidiaries from unfair and inappropriate competition. 

(b)         NON-COMPETITION. For the period beginning on the date hereof and ending nine (9)
months immediately following termination of Executive’s employment with the Company for any reason (the “Restricted Period”), except as otherwise permitted in accordance with Section 3 or as otherwise approved in writing by the Board,
Executive agrees and covenants not to directly or indirectly, on behalf of any individual or entity other than the Company, Parent or any of the Subsidiaries, perform services in any capacity (whether as an owner, employee, partner, independent
contractor or otherwise, whether with or without compensation) directly or 

  
 7 

 
indirectly in all or any portion of any business that the Company, Parent or any of the Subsidiaries conducts or is developing at the time of separation (the “Business”) as of the date
of such termination, in any geographic area in which the Company, Parent or any of the Subsidiaries conducts the Business, or is planning to conduct the Business. 

(c)         NON-SOLICITATION. During the Restricted Period, except as approved in writing by
the Board, Executive agrees and covenants not to directly or indirectly solicit, hire, recruit, attempt to hire or recruit, or induce the termination of employment of any employee of the Company, Parent and any of the Subsidiaries. 

(d)         MUTUAL NON-DISPARAGEMENT. Executive agrees and covenants that Executive will not at
any time make, publish or communicate to any person or entity or in any public forum any defamatory or disparaging remarks, comments or statements concerning the Business or the Company, or any of their respective employees or officers. This Section
12(d) does not, in any way, restrict or impede Executive from exercising protected rights to the extent that such rights cannot be waived by agreement or from complying with any applicable law or regulation or a valid order of a court of competent
jurisdiction or any authorized government agency, provided that such compliance does not exceed that required by the law, regulation or order. Executive shall promptly provide written notice of any such order to the Board of the Company. The Company
agrees to refrain from any disparaging statements about Executive. Executive understands that the Company obligations under this paragraph extend only to the Company’s executive officers and only for so long as each officer is an employee.
Nothing in this paragraph will prohibit either party from providing truthful information in response to a subpoena or other legal process. 

13.         ENFORCEMENT. Executive acknowledges and agrees that the Company will suffer
irreparable harm in the event that Executive breaches any of Executive’s obligations under Sections 10, 11 or 12 of this Agreement and that monetary damages would be inadequate to compensate the Company for such breach. Accordingly, Executive
agrees that, in the event of a breach by Executive of any of Executive’s obligations under Sections 10, 11 or 12 of this Agreement, the Company will be entitled to obtain from any court of competent jurisdiction preliminary and permanent
injunctive relief, and expedited discovery for the purpose of seeking relief, in order to prevent or to restrain any such breach. For avoidance of doubt, references to the “Company” in this Section 13 shall be deemed to include the
Company, Parent and its Subsidiaries, as applicable. 
 14.         DIRECTORS’ AND
OFFICERS’ INDEMNIFICATION AND INSURANCE. The Company will indemnify Executive to the maximum extent permitted by applicable law, as well as in accordance with the Company’s, Parent’s, or any Subsidiary’s Certificate of
Incorporation or Bylaws, as the case may be, and any separate written indemnification agreement entered into between Executive and the Company with respect to Executive’s service. The Company will enter into an indemnification agreement with
Executive on substantially the same terms and conditions as with its other senior executive officers and directors, if any. The Company will maintain directors’ and officers’ insurance, covering Executive, to the extent available on
commercially reasonable terms, in an amount of not less than the amount in coverage applicable to the Company’s other senior executive officers and directors. 

  
 8 

 15.         NOTICES. Any notice required to be
given hereunder will be sufficient if in writing and hand delivered (including by e-mail) or sent either by a nationally recognized overnight courier, freight prepaid, specifying next business day delivery or by certified or registered mail, return
receipt requested, first-class postage prepaid, in the case of Executive, to his address shown on the Company’s records, and in the case of the Company, to its principal office. 

16.         WAIVER. No waiver of any provision of this Agreement will be valid unless the same
is in writing and signed by the party against whom such waiver is sought to be enforced. Failure to insist upon strict compliance with any of the terms, covenants or conditions hereof will not be deemed a waiver of such terms, covenants or
conditions, nor will any waiver or relinquishment of any right or power granted hereunder at any particular time be deemed a waiver or relinquishment of such rights or power at any other time or times. 

17.         GOVERNING LAW; VENUE. This Agreement will be governed by and construed in
accordance with the laws of the State of Texas, without regard to that body of law known as choice of law. The parties agree that any litigation arising out of or related to this Agreement or Executive’s employment by the Company will be
brought exclusively in any state or federal court in Travis County, Texas. Each party (i) consents to the personal jurisdiction of said courts, (ii) waives any venue or inconvenient forum defense to any proceeding maintained in such courts, and
(iii) agrees not to bring any proceeding arising out of or relating to this Agreement or Executive’s employment by the Company in any other court. The prevailing party in any dispute between the parties will be entitled to reimbursement of
reasonable attorneys’ fees and expenses incurred in connection therewith. 
 18.
        BENEFIT. This Agreement will be binding upon and will inure to the benefit of each of the parties hereto, and to their respective heirs, representatives, successors and permitted assigns.
Executive may not assign any of his rights or delegate any of his duties under this Agreement. 
 19.
        ENTIRE AGREEMENT. This Agreement contains the entire agreement and understanding by and between the Company and Executive with respect to the terms described herein, and any representations,
promises, agreements or understandings, written or oral, not herein contained will be of no force or effect. No change or modification hereof will be valid or binding unless the same is in writing and signed by the parties hereto. 

20.         CAPTIONS; RULE OF CONSTRUCTION. The captions in this Agreement are for convenience
only and in no way define, bind or describe the scope or intent of this Agreement. The terms and provisions of this Agreement will not be construed against the drafter or drafters hereof. All parties hereto agree that the language of this Agreement
will be construed as a whole according to its fair meaning and not strictly for or against any of the parties hereto. 
 21.
        COUNTERPARTS. This Agreement may be executed in one or more counterparts, each of which will be deemed an original but all of which together will constitute one and the same agreement. Facsimile
or PDF reproductions of original signatures will be deemed binding for the purpose of the execution of this Agreement. 

  
 9 

 22.         SEVERABILITY. Each provision of this
Agreement is severable from every other provision of this Agreement. Any provision of this Agreement that is determined by any court of competent jurisdiction to be invalid or unenforceable will not affect the validity or enforceability of any other
provision. Any provision of this Agreement held invalid or unenforceable only in part or degree will remain in full force and effect to the extent not held invalid or unenforceable. 

23.         SURVIVAL. The terms of Sections 6 through 22 will survive the termination of this
Agreement for any reason. 
 [Signature page follows] 

  
 10 

 IN WITNESS WHEREOF, the parties have executed this Agreement effective as of the Effective Date.

  

			
	AEGLEA DEVELOPMENT COMPANY, INC:
		
	By:	 	/s/ Charles N. York II
	Name: Charles N. York II
	Title: Vice President of Finance
	
	EXECUTIVE:
	
	 /s/ David G. Lowe

	David G. Lowe

  
  
  

 
  

[SIGNATURE PAGE TO EXECUTIVE EMPLOYMENT AGREEMENT]

 EXHIBIT A 

Permitted Activities 
 Member,
Board of Directors and Investment Committee, MaRS Innovation, Toronto Canada.

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