Document:

<PAGE>

                                                                     EXHIBIT 4.3

                                 [Face of Note]

                                                          CUSIP/CINS ___________

                           4.00% Senior Notes due 2009

No. ___                                                            $____________

                                   AMGEN INC.

promises to pay to CEDE & CO. or registered assigns,

the principal sum of _____________________ on November 18, 2009.

Interest Payment Dates: May 18 and November 18

Record Dates: 15th day prior to May 18 and November 18

Dated: November 18, 2004

                                              AMGEN INC.

                                              By: ______________________________
                                                  Name:
                                                  Title:

                                              By: ______________________________
                                                  Name:
                                                  Title:

This is one of the Notes referred to
in the within-mentioned Indenture:

JPMorgan Chase Bank, N.A.,
  as Trustee

By: ________________________________
          Authorized Officer

                                       1
<PAGE>

                                 [Back of Note]
                           4.00% SENIOR NOTES DUE 2009

[GLOBAL LEGEND]

      THIS  SECURITY  IS  A GLOBAL SECURITY WITHIN THE MEANING OF THE  INDENTURE
HEREINAFTER  REFERRED  TO  AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR  A
NOMINEE  OF  THE  DEPOSITORY.  THIS  SECURITY  IS  EXCHANGEABLE  FOR  SECURITIES
REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY
IN  THE  LIMITED  CIRCUMSTANCES  DESCRIBED  IN  THE  INDENTURE,  AND MAY NOT  BE
TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE  DEPOSITORY,
BY  A  NOMINEE  OF  THE  DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF  THE
DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR
A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY.

[TRANSFER RESTRICTED LEGEND]

      THIS  NOTE  HAS  NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,  AS
AMENDED  (THE  "SECURITIES  ACT"),  AND ACCORDINGLY, MAY NOT BE OFFERED OR  SOLD
WITHIN  THE UNITED STATES OR TO, OR FOR THE ACCOUNT OR BENEFIT OF, U.S.  PERSONS
EXCEPT  AS  SET FORTH IN THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF,  THE
HOLDER  (I)  REPRESENTS  THAT  (A)  IT IS A "QUALIFIED INSTITUTIONAL BUYER"  (AS
DEFINED  IN  RULE  144A UNDER THE SECURITIES ACT) OR (B) IT IS AN  INSTITUTIONAL
"ACCREDITED  INVESTOR"  (AS  DEFINED  IN  RULE  501(A)(1),  (2),  (3) OR (7)  OF
REGULATION D UNDER THE SECURITIES ACT) (AN "INSTITUTIONAL ACCREDITED  INVESTOR")
OR  (C)  IT  IS  NOT  A  U.S.  PERSON AND IS ACQUIRING THIS NOTE IN AN  OFFSHORE
TRANSACTION (AS DEFINED IN REGULATION S UNDER THE SECURITIES ACT) IN  COMPLIANCE
WITH REGULATION S UNDER THE SECURITIES ACT, (2) AGREES THAT IT WILL NOT,  WITHIN
THE TIME PERIOD REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AS IN EFFECT
ON THE DATE OF THE TRANSFER OF THIS NOTE, RESELL OR OTHERWISE TRANSFER THIS NOTE
EXCEPT  (A)  TO  THE  ISSUER  OR  ANY  SUBSIDIARY  THEREOF,  (B) TO A  QUALIFIED
INSTITUTIONAL  BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT,  (C)
INSIDE THE UNITED STATES TO AN INSTITUTIONAL ACCREDITED INVESTOR THAT, PRIOR  TO
SUCH  TRANSFER,  FURNISHES  TO  THE  TRUSTEE A SIGNED LETTER CONTAINING  CERTAIN
REPRESENTATIONS AND AGREEMENTS RELATING TO THE RESTRICTIONS ON TRANSFER OF  THIS
NOTE  (THE  FORM  OF WHICH LETTER CAN BE OBTAINED FROM THE TRUSTEE) AND IF  SUCH
TRANSFER  IS  IN RESPECT OF AN AGGREGATE PRINCIPAL AMOUNT OF NOTES OF LESS  THAN
$100,000,  AN OPINION OF COUNSEL ACCEPTABLE TO THE ISSUER THAT SUCH TRANSFER  IS
IN  COMPLIANCE  WITH  THE  SECURITIES  ACT, (D) OUTSIDE THE UNITED STATES IN  AN
OFFSHORE  TRANSACTION IN COMPLIANCE WITH RULE 904 UNDER THE SECURITIES ACT,  (E)
PURSUANT  TO  THE EXEMPTION FROM REGISTRATION PROVIDED UNDER THE SECURITIES  ACT
(IF AVAILABLE) OR (F) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER  THE
SECURITIES  ACT  AND  IN EACH CASE IN ACCORDANCE WITH ANY APPLICABLE  SECURITIES
LAWS  OF  ANY  STATE OF THE UNITED STATES. PRIOR TO ANY TRANSFER, THE HOLDER  OF
THIS  SECURITY  AGREES THAT IT WILL DELIVER TO EACH PERSON TO WHOM THIS NOTE  IS
TRANSFERRED A NOTICE SUBSTANTIALLY TO THE EFFECT OF THIS

                                       2
<PAGE>

LEGEND.  IN  CONNECTION  WITH  ANY TRANSFER OF THIS NOTE WITHIN THE TIME  PERIOD
REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AFTER THE ORIGINAL  ISSUANCE
OF THE NOTES, THE HOLDER MUST CHECK THE APPROPRIATE BOX SET FORTH ON THE REVERSE
HEREOF  RELATING  TO THE MANNER OF SUCH TRANSFER AND SUBMIT THIS CERTIFICATE  TO
THE TRUSTEE. IF THE PROPOSED TRANSFEREE IS AN INSTITUTIONAL ACCREDITED  INVESTOR
OR  A  NON-U.S. PERSON, THE HOLDER MUST, PRIOR TO SUCH TRANSFER, FURNISH TO  THE
TRUSTEE AND THE COMPANY SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION
AS EITHER OF THEM MAY REASONABLY REQUIRE TO CONFIRM THAT SUCH TRANSFER IS  BEING
MADE  PURSUANT  TO  AN  EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO,  THE
REGISTRATION  REQUIREMENTS  OF  THE  SECURITIES  ACT. AS USED HEREIN, THE  TERMS
"OFFSHORE  TRANSACTION."  "UNITED  STATES"  AND "U.S. PERSON" HAVE THE  MEANINGS
GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT. THE INDENTURE CONTAINS A
PROVISION REQUIRING THE TRUSTEE TO REFUSE TO REGISTER ANY TRANSFER OF THIS  NOTE
IN VIOLATION OF THE FOREGOING RESTRICTION.

      Capitalized  terms  used herein have the meanings assigned to them in  the
Indenture referred to below unless otherwise indicated.

            (1)  INTEREST.  Amgen Inc., a Delaware corporation (the  "Company"),
      promises to pay interest on the principal amount of this Note at 4.00% per
      annum  from  November  18,  2004 until maturity and shall pay the  Special
      Interest  (as  defined  in  the  Registration  Rights Agreement), if  any,
      payable  pursuant  to  Section  4  of  the  Registration Rights  Agreement
      referred to below. The Company will pay interest and Special Interest,  if
      any,  semi-annually in arrears on May 18 and November 18 of each year,  or
      if any such day is not a Business Day, on the next succeeding Business Day
      (each, an "Interest Payment Date"). Interest on the Notes will accrue from
      the  most  recent date to which interest has been paid or, if no  interest
      has been paid, from the date of issuance; provided that the first Interest
      Payment  Date  shall be May 18, 2005; provided further that after May  18,
      2005,  if there is no existing Default in the payment of interest, and  if
      this  Note is authenticated between a record date referred to on the  face
      hereof  and  the  next  succeeding  Interest Payment Date, interest  shall
      accrue from such next succeeding Interest Payment Date.

            (2)  METHOD  OF PAYMENT. The Company will pay interest on the  Notes
      (except  defaulted interest) and Special Interest, if any, to the  Persons
      who  are  registered Holders of Notes at the close of business on the  day
      that  is  15  days  prior  to  the  next succeeding Interest Payment  Date
      (whether  or  not  such  day  is  a Business Day), even if such Notes  are
      canceled  after  such  record date and on or before such Interest  Payment
      Date, except as provided in Section 2.13 of the Indenture with respect  to
      defaulted  interest.  The Notes will be payable as to principal,  interest
      and  Special  Interest,  if  any,  at the office or agency of the  Company
      maintained  for  such  purpose  in the Borough of Manhattan, the City  and
      State  of  New  York (or, if the Company fails to maintain such office  or
      agency, at the corporate trust office of the trustee in New York, New York
      or  if the trustee does not maintain an office in New York, at the  office
      of a paying agent in New York), or, at the option of the Company,  payment
      of  interest and Special Interest, if any, may be made by check mailed  to
      the  Holders  at  their  addresses  set forth in the register of  Holders;
      provided that payment by wire transfer of immediately available funds will
      be  required  with  respect  to  principal  of  and  interest and  Special
      Interest,  if  any,  on,  all  Global  Securities and all other Notes  the
      Holders  of  which  will  have provided wire transfer instructions to  the
      Company  or the Paying Agent. Such payment will be in the currency of  the
      United States of America.

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<PAGE>

            (3)  PAYING  AGENT  AND  REGISTRAR. Initially, JPMorgan Chase  Bank,
      N.A.,  the  Trustee  under  the  Indenture,  will act as Paying Agent  and
      Registrar.  The  Company may change any Paying Agent or Registrar  without
      notice  to  any Holder. The Company or any of its Subsidiaries may act  in
      any such capacity.

            (4)  INDENTURE.  The terms of the Notes include those stated in  the
      Indenture  and  those  made  part  of  the  Indenture  by  the   Officers'
      Certificate  dated  November  18,  2004  delivered  pursuant thereto  (the
      "Officers'  Certificate")  and the TIA. The Notes are subject to all  such
      terms,  and  the  Holders are referred to the Indenture and the TIA for  a
      statement of them.

            (5) OPTIONAL REDEMPTION. At any time prior to maturity, the  Company
      will  have  the option to redeem all or a part of the Notes upon not  less
      than 30 nor more than 60 days' notice, at a redemption price equal to  the
      sum  of (1) 100% of the principal amount of any notes being redeemed  plus
      accrued  and  unpaid interest to, but not including, the redemption  date,
      and (2) the Make-Whole Amount. Unless the Company defaults in the  payment
      of  the  redemption  price, interest will cease to accrue on the Notes  or
      portions thereof called for redemption on the applicable redemption  date.

            (6)  MANDATORY  REDEMPTION.  The  Company  is  not required to  make
      mandatory  redemption or sinking fund payments with respect to the  Notes.

            (7)  NOTICE  OF  REDEMPTION. Notice of redemption will be mailed  at
      least 30 days but not more than 60 days before the redemption date to each
      Holder  whose  Notes are to be redeemed at its registered address,  except
      that  redemption  notices  may  be  mailed  more  than 60 days prior to  a
      redemption date if the notice is issued in connection with a defeasance of
      the  Notes  or  a  satisfaction  or  discharge of the Indenture. Notes  in
      denominations larger than $1,000 may be redeemed in part but only in whole
      multiples  of  $1,000, unless all of the Notes held by a Holder are to  be
      redeemed.

            (8) DEFEASANCE PRIOR TO MATURITY. The Indenture contains  provisions
      for defeasance of (i) the entire indebtedness of the Notes or (ii) certain
      covenants  and  Events of Default with respect to the Notes, in each  case
      upon compliance with certain conditions set forth therein.

            (9)   RESTRICTIVE   COVENANTS.  The  Indenture  and  the   Officers'
      Certificate   impose   certain  limitations  on  the  Company's  and   its
      Subsidiaries', including limitations on the Company's and its subsidiaries
      ability  to  create  or  incur  certain  Liens on any of their  respective
      properties  or  assets  and  to  enter  into  certain sale and  lease-back
      transactions  and  on  the  Company's  ability  to  engage  in mergers  or
      consolidations   or   the   conveyance,  transfer  or  lease  of  all   or
      substantially  all  of  its  properties and assets. These limitations  are
      subject  to  a  number  of  important  qualifications  and exceptions  and
      reference  is  made  to the Indenture and the Officers' Certificate for  a
      description thereof.

            (10) DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in  registered
      form without coupons in denominations of $1,000 and integral multiples  of
      $1,000. The transfer of Notes may be registered and Notes may be exchanged
      as provided in the Indenture. The Registrar and the Trustee may require  a
      Holder,  among  other  things,  to  furnish  appropriate endorsements  and
      transfer  documents and the Company may require a Holder to pay any  taxes
      and  fees required by law or permitted by the Indenture. The Company  need
      not  exchange  or  register the transfer of any Note or portion of a  Note
      selected  for  redemption,  except for the unredeemed portion of any  Note
      being  redeemed  in part. Also, the Company need not exchange or  register
      the transfer of

                                       4
<PAGE>

      any  Notes  for  a  period  of  15 days before a selection of Notes to  be
      redeemed or during the period between a record date and the  corresponding
      Interest Payment Date.

            (11)  PERSONS DEEMED OWNERS. The registered Holder of a Note may  be
      treated as its owner for all purposes.

            (12)   AMENDMENT,   SUPPLEMENT   AND  WAIVER.  Subject  to   certain
      exceptions, the Indenture or the Notes may be amended or supplemented with
      the  consent of the Holders of at least a majority in aggregate  principal
      amount  of  the  then outstanding Notes voting as a single class, and  any
      existing  Default or Event or Default or compliance with any provision  of
      the  Indenture or the Notes may be waived with the consent of the  Holders
      of a majority in aggregate principal amount of the then outstanding  Notes
      voting as a single class. Without the consent of any Holder of a Note, the
      Indenture  or  the  Notes  may  be  amended  or  supplemented to cure  any
      ambiguity, defect or inconsistency, to provide for uncertificated Notes in
      addition  to  or  in place of certificated Notes, to make any change  that
      would  not  adversely  affect the legal rights under the Indenture of  any
      such  Holder,  to  provide  for  the  issuance of any additional notes  as
      permitted by the Indenture, to appoint a successor trustee with respect to
      the  notes and to add to or change any of the provisions of the  Indenture
      necessary to provide for the administration of the trusts in the indenture
      by more than one trustee, or to comply with the requirements of the SEC in
      order  to effect or maintain the qualification of the Indenture under  the
      TIA.

            (13)  DEFAULTS AND REMEDIES. If an Event of Default shall occur  and
      be continuing, the principal of the Notes may be declared (or, in  certain
      cases, shall ipso facto become) due and payable in the manner and with the
      effect provided in the Indenture.

            (14) TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture,
      in  its individual or any other capacity, may deal with the Company or  an
      Affiliate of the Company with the same rights it would have if it were not
      Trustee.

            (15)  NO  RECOURSE AGAINST OTHERS. A director, officer, employee  or
      stockholder  of  the  Company  shall  not  have  any  liability  for   any
      obligations  of  the  Company under the Notes or the Indenture or for  any
      claim based on, in respect of, or by reason of, such obligations or  their
      creation.  Each  Holder  by accepting a Note waives and releases all  such
      liability.  The  waiver and release are part of the consideration for  the
      issuance of the Notes.

            (16) AUTHENTICATION. This Note will not be valid until authenticated
      by the manual signature of the Trustee or an authenticating agent.

            (17) ABBREVIATIONS. Customary abbreviations may be used in the  name
      of  a  Holder or an assignee, such as: TEN COM (= tenants in common),  TEN
      ENT  (= tenants by the entireties), JT TEN (= joint tenants with right  of
      survivorship  and  not  as  tenants  in  common), CUST (= Custodian),  and
      U/G/M/A (= Uniform Gifts to Minors Act).

            (18)  REGISTRATION  RIGHTS  OF  HOLDERS.  In addition to the  rights
      provided  to  Holders of Notes under the Indenture, Holders of  restricted
      Notes  will  have  all  the  rights  set forth in the Registration  Rights
      Agreement,  dated  as  of  November 18, 2004, between the Company and  the
      other  parties  named  on  the signature pages thereof (the  "Registration
      Rights Agreement").

            (19) CUSIP NUMBERS. Pursuant to a recommendation promulgated by  the
      Committee  on Uniform Security Identification Procedures, the Company  has
      caused  CUSIP numbers to be printed on the Notes, and the Trustee may  use
      CUSIP numbers in notices of redemption as a

                                       5
<PAGE>

      convenience  to  Holders. No representation is made as to the accuracy  of
      such numbers either as printed on the Notes or as contained in any  notice
      of redemption, and reliance may be placed only on the other identification
      numbers placed thereon.

            (20)  GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK  WILL
      GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT  GIVING
      EFFECT TO APPLICABLE PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE
      APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY.

      The  Company  will furnish to any Holder upon written request and  without
charge  a  copy  of  the  Indenture  and/or  the Registration Rights  Agreement.
Requests may be made to:

                                   Amgen Inc.
                             One Amgen Center Drive
                          Thousand Oaks, CA 91320-1799
                          Attention: Investor Relations

                                       6
<PAGE>

                                 ASSIGNMENT FORM

      To assign this Note, fill in the form below:

(I) or (we) assign and transfer this Note to: __________________________________
                                                (Insert assignee's legal name)

_______________________________________________________________________________
                  (Insert assignee's soc. sec. or tax I.D. no.)

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________
              (Print or type assignee's name, address and zip code)

and irrevocably appoint ________________________________________________________
to transfer this Note on the books of the Company. The agent may substitute
another to act for him.

Date: _______________

                                    Your Signature: ___________________________
                                             (Sign exactly as your name appears
                                              on the face of this Note)

Signature Guarantee*: _________________________

* Participant in a recognized Signature Guarantee Medallion Program (or other
signature guarantor acceptable to the Trustee).

                                       7<PAGE>

                                                                     EXHIBIT 4.4

                                 [Face of Note]

                                                          CUSIP/CINS ___________

                           4.85% Senior Notes due 2014

No. ___                                                            $____________

                                   AMGEN INC.

promises to pay to CEDE & CO. or registered assigns,

the principal sum of _____________________ on November 18, 2014.

Interest Payment Dates: May 18 and November 18

Record Dates: 15th day prior to May 18 and November 18

Dated: November 18, 2004

                                               AMGEN INC.

                                               By:
                                                   -----------------------------
                                                   Name:
                                                   Title:

                                               By:
                                                   -----------------------------
                                                   Name:
                                                   Title:

This is one of the Notes referred to
in the within-mentioned Indenture:

JPMorgan Chase Bank, N.A.,
  as Trustee

By:
    -----------------------------
         Authorized Officer

                                       1
<PAGE>

                                 [Back of Note]
                           4.85% SENIOR NOTES DUE 2014

[GLOBAL LEGEND]

      THIS  SECURITY  IS  A GLOBAL SECURITY WITHIN THE MEANING OF THE  INDENTURE
HEREINAFTER  REFERRED  TO  AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR  A
NOMINEE  OF  THE  DEPOSITORY.  THIS  SECURITY  IS  EXCHANGEABLE  FOR  SECURITIES
REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY
IN  THE  LIMITED  CIRCUMSTANCES  DESCRIBED  IN  THE  INDENTURE,  AND MAY NOT  BE
TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE  DEPOSITORY,
BY  A  NOMINEE  OF  THE  DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF  THE
DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR
A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY.

[TRANSFER RESTRICTED LEGEND]

      THIS  NOTE  HAS  NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,  AS
AMENDED  (THE  "SECURITIES  ACT"),  AND ACCORDINGLY, MAY NOT BE OFFERED OR  SOLD
WITHIN  THE UNITED STATES OR TO, OR FOR THE ACCOUNT OR BENEFIT OF, U.S.  PERSONS
EXCEPT  AS  SET FORTH IN THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF,  THE
HOLDER  (I)  REPRESENTS  THAT  (A)  IT IS A "QUALIFIED INSTITUTIONAL BUYER"  (AS
DEFINED  IN  RULE  144A UNDER THE SECURITIES ACT) OR (B) IT IS AN  INSTITUTIONAL
"ACCREDITED  INVESTOR"  (AS  DEFINED  IN  RULE  501(A)(1),  (2),  (3) OR (7)  OF
REGULATION D UNDER THE SECURITIES ACT) (AN "INSTITUTIONAL ACCREDITED  INVESTOR")
OR  (C)  IT  IS  NOT  A  U.S.  PERSON AND IS ACQUIRING THIS NOTE IN AN  OFFSHORE
TRANSACTION (AS DEFINED IN REGULATION S UNDER THE SECURITIES ACT) IN  COMPLIANCE
WITH REGULATION S UNDER THE SECURITIES ACT, (2) AGREES THAT IT WILL NOT,  WITHIN
THE TIME PERIOD REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AS IN EFFECT
ON THE DATE OF THE TRANSFER OF THIS NOTE, RESELL OR OTHERWISE TRANSFER THIS NOTE
EXCEPT  (A)  TO  THE  ISSUER  OR  ANY  SUBSIDIARY  THEREOF,  (B) TO A  QUALIFIED
INSTITUTIONAL  BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT,  (C)
INSIDE THE UNITED STATES TO AN INSTITUTIONAL ACCREDITED INVESTOR THAT, PRIOR  TO
SUCH  TRANSFER,  FURNISHES  TO  THE  TRUSTEE A SIGNED LETTER CONTAINING  CERTAIN
REPRESENTATIONS AND AGREEMENTS RELATING TO THE RESTRICTIONS ON TRANSFER OF  THIS
NOTE  (THE  FORM  OF WHICH LETTER CAN BE OBTAINED FROM THE TRUSTEE) AND IF  SUCH
TRANSFER  IS  IN RESPECT OF AN AGGREGATE PRINCIPAL AMOUNT OF NOTES OF LESS  THAN
$100,000,  AN OPINION OF COUNSEL ACCEPTABLE TO THE ISSUER THAT SUCH TRANSFER  IS
IN  COMPLIANCE  WITH  THE  SECURITIES  ACT, (D) OUTSIDE THE UNITED STATES IN  AN
OFFSHORE  TRANSACTION IN COMPLIANCE WITH RULE 904 UNDER THE SECURITIES ACT,  (E)
PURSUANT  TO  THE EXEMPTION FROM REGISTRATION PROVIDED UNDER THE SECURITIES  ACT
(IF AVAILABLE) OR (F) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER  THE
SECURITIES  ACT  AND  IN EACH CASE IN ACCORDANCE WITH ANY APPLICABLE  SECURITIES
LAWS  OF  ANY  STATE OF THE UNITED STATES. PRIOR TO ANY TRANSFER, THE HOLDER  OF
THIS  SECURITY  AGREES THAT IT WILL DELIVER TO EACH PERSON TO WHOM THIS NOTE  IS
TRANSFERRED A NOTICE SUBSTANTIALLY TO THE EFFECT OF THIS

                                       2
<PAGE>

LEGEND.  IN  CONNECTION  WITH  ANY TRANSFER OF THIS NOTE WITHIN THE TIME  PERIOD
REFERRED TO IN RULE 144(K) UNDER THE SECURITIES ACT AFTER THE ORIGINAL  ISSUANCE
OF THE NOTES, THE HOLDER MUST CHECK THE APPROPRIATE BOX SET FORTH ON THE REVERSE
HEREOF  RELATING  TO THE MANNER OF SUCH TRANSFER AND SUBMIT THIS CERTIFICATE  TO
THE TRUSTEE. IF THE PROPOSED TRANSFEREE IS AN INSTITUTIONAL ACCREDITED  INVESTOR
OR  A  NON-U.S. PERSON, THE HOLDER MUST, PRIOR TO SUCH TRANSFER, FURNISH TO  THE
TRUSTEE AND THE COMPANY SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION
AS EITHER OF THEM MAY REASONABLY REQUIRE TO CONFIRM THAT SUCH TRANSFER IS  BEING
MADE  PURSUANT  TO  AN  EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO,  THE
REGISTRATION  REQUIREMENTS  OF  THE  SECURITIES  ACT. AS USED HEREIN, THE  TERMS
"OFFSHORE  TRANSACTION."  "UNITED  STATES"  AND "U.S. PERSON" HAVE THE  MEANINGS
GIVEN TO THEM BY REGULATION S UNDER THE SECURITIES ACT. THE INDENTURE CONTAINS A
PROVISION REQUIRING THE TRUSTEE TO REFUSE TO REGISTER ANY TRANSFER OF THIS  NOTE
IN VIOLATION OF THE FOREGOING RESTRICTION.

      Capitalized  terms  used herein have the meanings assigned to them in  the
Indenture referred to below unless otherwise indicated.

            (1)  INTEREST.  Amgen Inc., a Delaware corporation (the  "Company"),
      promises to pay interest on the principal amount of this Note at 4.85% per
      annum  from  November  18,  2004 until maturity and shall pay the  Special
      Interest  (as  defined  in  the  Registration  Rights Agreement), if  any,
      payable  pursuant  to  Section  4  of  the  Registration Rights  Agreement
      referred to below. The Company will pay interest and Special Interest,  if
      any,  semi-annually in arrears on May 18 and November 18 of each year,  or
      if any such day is not a Business Day, on the next succeeding Business Day
      (each, an "Interest Payment Date"). Interest on the Notes will accrue from
      the  most  recent date to which interest has been paid or, if no  interest
      has been paid, from the date of issuance; provided that the first Interest
      Payment  Date  shall be May 18, 2005; provided further that after May  18,
      2005,  if there is no existing Default in the payment of interest, and  if
      this  Note is authenticated between a record date referred to on the  face
      hereof  and  the  next  succeeding  Interest Payment Date, interest  shall
      accrue from such next succeeding Interest Payment Date.

            (2)  METHOD  OF PAYMENT. The Company will pay interest on the  Notes
      (except  defaulted interest) and Special Interest, if any, to the  Persons
      who  are  registered Holders of Notes at the close of business on the  day
      that  is  15  days  prior  to  the  next succeeding Interest Payment  Date
      (whether  or  not  such  day  is  a Business Day), even if such Notes  are
      canceled  after  such  record date and on or before such Interest  Payment
      Date, except as provided in Section 2.13 of the Indenture with respect  to
      defaulted  interest.  The Notes will be payable as to principal,  interest
      and  Special  Interest,  if  any,  at the office or agency of the  Company
      maintained  for  such  purpose  in the Borough of Manhattan, the City  and
      State  of  New  York (or, if the Company fails to maintain such office  or
      agency, at the corporate trust office of the trustee in New York, New York
      or  if the trustee does not maintain an office in New York, at the  office
      of a paying agent in New York), or, at the option of the Company,  payment
      of  interest and Special Interest, if any, may be made by check mailed  to
      the  Holders  at  their  addresses  set forth in the register of  Holders;
      provided that payment by wire transfer of immediately available funds will
      be  required  with  respect  to  principal  of  and  interest and  Special
      Interest,  if  any,  on,  all  Global  Securities and all other Notes  the
      Holders  of  which  will  have provided wire transfer instructions to  the
      Company  or the Paying Agent. Such payment will be in the currency of  the
      United States of America.

                                       3
<PAGE>

            (3)  PAYING  AGENT  AND  REGISTRAR. Initially, JPMorgan Chase  Bank,
      N.A.,  the  Trustee  under  the  Indenture,  will act as Paying Agent  and
      Registrar.  The  Company may change any Paying Agent or Registrar  without
      notice  to  any Holder. The Company or any of its Subsidiaries may act  in
      any such capacity.

            (4)  INDENTURE.  The terms of the Notes include those stated in  the
      Indenture  and  those  made  part  of  the  Indenture  by  the   Officers'
      Certificate  dated  November  18,  2004  delivered  pursuant thereto  (the
      "Officers'  Certificate")  and the TIA. The Notes are subject to all  such
      terms,  and  the  Holders are referred to the Indenture and the TIA for  a
      statement of them.

            (5) OPTIONAL REDEMPTION. At any time prior to maturity, the  Company
      will  have  the option to redeem all or a part of the Notes upon not  less
      than 30 nor more than 60 days' notice, at a redemption price equal to  the
      sum  of (1) 100% of the principal amount of any notes being redeemed  plus
      accrued  and  unpaid interest to, but not including, the redemption  date,
      and (2) the Make-Whole Amount. Unless the Company defaults in the  payment
      of  the  redemption  price, interest will cease to accrue on the Notes  or
      portions thereof called for redemption on the applicable redemption  date.

            (6)  MANDATORY  REDEMPTION.  The  Company  is  not required to  make
      mandatory  redemption or sinking fund payments with respect to the  Notes.

            (7)  NOTICE  OF  REDEMPTION. Notice of redemption will be mailed  at
      least 30 days but not more than 60 days before the redemption date to each
      Holder  whose  Notes are to be redeemed at its registered address,  except
      that  redemption  notices  may  be  mailed  more  than 60 days prior to  a
      redemption date if the notice is issued in connection with a defeasance of
      the  Notes  or  a  satisfaction  or  discharge of the Indenture. Notes  in
      denominations larger than $1,000 may be redeemed in part but only in whole
      multiples  of  $1,000, unless all of the Notes held by a Holder are to  be
      redeemed.

            (8) DEFEASANCE PRIOR TO MATURITY. The Indenture contains  provisions
      for defeasance of (i) the entire indebtedness of the Notes or (ii) certain
      covenants  and  Events of Default with respect to the Notes, in each  case
      upon compliance with certain conditions set forth therein.

            (9)   RESTRICTIVE   COVENANTS.  The  Indenture  and  the   Officers'
      Certificate   impose   certain  limitations  on  the  Company's  and   its
      Subsidiaries', including limitations on the Company's and its subsidiaries
      ability  to  create  or  incur  certain  Liens on any of their  respective
      properties  or  assets  and  to  enter  into  certain sale and  lease-back
      transactions  and  on  the  Company's  ability  to  engage  in mergers  or
      consolidations   or   the   conveyance,  transfer  or  lease  of  all   or
      substantially  all  of  its  properties and assets. These limitations  are
      subject  to  a  number  of  important  qualifications  and exceptions  and
      reference  is  made  to the Indenture and the Officers' Certificate for  a
      description thereof.

            (10) DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in  registered
      form without coupons in denominations of $1,000 and integral multiples  of
      $1,000. The transfer of Notes may be registered and Notes may be exchanged
      as provided in the Indenture. The Registrar and the Trustee may require  a
      Holder,  among  other  things,  to  furnish  appropriate endorsements  and
      transfer  documents and the Company may require a Holder to pay any  taxes
      and  fees required by law or permitted by the Indenture. The Company  need
      not  exchange  or  register the transfer of any Note or portion of a  Note
      selected  for  redemption,  except for the unredeemed portion of any  Note
      being  redeemed  in part. Also, the Company need not exchange or  register
      the transfer of

                                       4
<PAGE>

      any  Notes  for  a  period  of  15 days before a selection of Notes to  be
      redeemed or during the period between a record date and the  corresponding
      Interest Payment Date.

            (11)  PERSONS DEEMED OWNERS. The registered Holder of a Note may  be
      treated as its owner for all purposes.

            (12)   AMENDMENT,   SUPPLEMENT   AND  WAIVER.  Subject  to   certain
      exceptions, the Indenture or the Notes may be amended or supplemented with
      the  consent of the Holders of at least a majority in aggregate  principal
      amount  of  the  then outstanding Notes voting as a single class, and  any
      existing  Default or Event or Default or compliance with any provision  of
      the  Indenture or the Notes may be waived with the consent of the  Holders
      of a majority in aggregate principal amount of the then outstanding  Notes
      voting as a single class. Without the consent of any Holder of a Note, the
      Indenture  or  the  Notes  may  be  amended  or  supplemented to cure  any
      ambiguity, defect or inconsistency, to provide for uncertificated Notes in
      addition  to  or  in place of certificated Notes, to make any change  that
      would  not  adversely  affect the legal rights under the Indenture of  any
      such  Holder,  to  provide  for  the  issuance of any additional notes  as
      permitted by the Indenture, to appoint a successor trustee with respect to
      the  notes and to add to or change any of the provisions of the  Indenture
      necessary to provide for the administration of the trusts in the indenture
      by more than one trustee, or to comply with the requirements of the SEC in
      order  to effect or maintain the qualification of the Indenture under  the
      TIA.

            (13)  DEFAULTS AND REMEDIES. If an Event of Default shall occur  and
      be continuing, the principal of the Notes may be declared (or, in  certain
      cases, shall ipso facto become) due and payable in the manner and with the
      effect provided in the Indenture.

            (14) TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture,
      in  its individual or any other capacity, may deal with the Company or  an
      Affiliate of the Company with the same rights it would have if it were not
      Trustee.

            (15)  NO  RECOURSE AGAINST OTHERS. A director, officer, employee  or
      stockholder  of  the  Company  shall  not  have  any  liability  for   any
      obligations  of  the  Company under the Notes or the Indenture or for  any
      claim based on, in respect of, or by reason of, such obligations or  their
      creation.  Each  Holder  by accepting a Note waives and releases all  such
      liability.  The  waiver and release are part of the consideration for  the
      issuance of the Notes.

            (16) AUTHENTICATION. This Note will not be valid until authenticated
      by the manual signature of the Trustee or an authenticating agent.

            (17) ABBREVIATIONS. Customary abbreviations may be used in the  name
      of  a  Holder or an assignee, such as: TEN COM (= tenants in common),  TEN
      ENT  (= tenants by the entireties), JT TEN (= joint tenants with right  of
      survivorship  and  not  as  tenants  in  common), CUST (= Custodian),  and
      U/G/M/A (= Uniform Gifts to Minors Act).

            (18)  REGISTRATION  RIGHTS  OF  HOLDERS.  In addition to the  rights
      provided  to  Holders of Notes under the Indenture, Holders of  restricted
      Notes  will  have  all  the  rights  set forth in the Registration  Rights
      Agreement,  dated  as  of  November 18, 2004, between the Company and  the
      other  parties  named  on  the signature pages thereof (the  "Registration
      Rights Agreement").

            (19) CUSIP NUMBERS. Pursuant to a recommendation promulgated by  the
      Committee  on Uniform Security Identification Procedures, the Company  has
      caused  CUSIP numbers to be printed on the Notes, and the Trustee may  use
      CUSIP numbers in notices of redemption as a

                                       5
<PAGE>

      convenience  to  Holders. No representation is made as to the accuracy  of
      such numbers either as printed on the Notes or as contained in any  notice
      of redemption, and reliance may be placed only on the other identification
      numbers placed thereon.

            (20)  GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK  WILL
      GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT  GIVING
      EFFECT TO APPLICABLE PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE
      APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY.

      The  Company  will furnish to any Holder upon written request and  without
charge  a  copy  of  the  Indenture  and/or  the Registration Rights  Agreement.
Requests may be made to:

                                   Amgen Inc.
                             One Amgen Center Drive
                          Thousand Oaks, CA 91320-1799
                          Attention: Investor Relations

                                       6
<PAGE>

                                 ASSIGNMENT FORM

      To assign this Note, fill in the form below:

(I) or (we) assign and transfer this Note to: _________________________________
                                               (Insert assignee's legal name)

_______________________________________________________________________________
                  (Insert assignee's soc. sec. or tax I.D. no.)

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________

_______________________________________________________________________________
              (Print or type assignee's name, address and zip code)

and irrevocably appoint ________________________________________________________
to transfer this Note on the books of the Company. The agent may substitute
another to act for him.

Date:  _______________

                               Your Signature: ________________________________
                                          (Sign exactly as your name appears on
                                           the face of this Note)

Signature Guarantee*: _________________________

* Participant in a recognized Signature Guarantee Medallion Program (or other
signature guarantor acceptable to the Trustee).

                                       7

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