Document:

<PAGE>

                                                                  EXHIBIT 10.156

               AMENDMENT NO. 3 TO CREDIT AND SECURITY AGREEMENT
               ------------------------------------------------

     THIS AMENDMENT NO. 3 TO CREDIT AND SECURITY AGREEMENT (this "Agreement")
made as of the 17th day of October, 2000, by and among APPLIED BIOSCIENCE
INTERNATIONAL INC., a Delaware corporation, its successors and assigns (the
"Lender"), ENVIRON HOLDINGS, INC., a Delaware corporation ("EHI"), ENVIRON
INTERNATIONAL CORPORATION (formerly APBI Environmental Sciences Group, Inc.), a
Virginia corporation ("EIC" together with EHI the "Original Borrowers"), and
ENVIRON FACILITY SERVICES CORPORATION, a Virginia corporation (the "New
Borrower"), jointly and severally (the Original Borrowers and the New Borrower,
each a "Borrower", and collectively, the "Borrowers").

                                   RECITALS
                                   --------

     A.  The Original Borrowers are parties to a certain Credit and Security
Agreement, along with the Lender dated February 2, 1999 (as thereafter amended,
modified, restated, substituted, extended and renewed from time to time, the
"Credit Agreement"), pursuant to which the Lender agreed to make available
certain credit facilities consisting of (i) a revolving credit facility (the
"Revolving Credit Facility") to provide working capital to the Original
Borrowers, (ii) a term loan (the "Term Loan") in the amount of Seven Million
Dollars ($7,000,000) to be used to pay a portion of the Purchase Price (as
defined in the Credit Agreement), (iii) letters of credit ("Letters of Credit")
to be used for general corporate purposes by the Original Borrowers, and (iv) an
acquisition loan in the amount of Eighteen Million Dollars ($18,000,000), also
to pay a portion of the Purchase Price.  As set forth in that certain Amendment
No. 2 and Restatement of Credit and Security Agreement dated November 24, 1999
by and among Lender and the
<PAGE>

Original Borrowers, the Term Loan has been satisfied and the Lender has no
obligation to make any loans under the Revolving Credit Facility or to issue any
Letters of Credit to or for the benefit of the Original Borrowers under the
Credit Agreement.

     B.  Pursuant to a plan of corporate restructuring approved by EIC's Board
of Directors, EIC has created a separate legal entity for its Facilities Group
in the form of the New Borrower and has transferred all of its assets related to
the Facilities Group to the New Borrower pursuant to that certain Asset Purchase
Agreement dated January 1, 2000 by and between EIC and the New Borrower (the
"Facilities Group Spin Off") and the Borrowers have requested that the Lender
consent to the Facilities Group Spin Off and the Lender has consented on the
condition, among others, that the parties hereto execute this Agreement.

     C.  The parties hereto desire to add the New Borrower as a party to the
Credit Agreement and to make certain other amendments to the Credit Agreement,
all as more fully set forth in this Agreement.

     NOW, THEREFORE, in consideration of the foregoing, and for other good and
valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the Borrowers and the Lender do hereby agree as follows:

     1.  Recitals. The parties hereto acknowledge and agree that the above
         --------
Recitals are true and correct in all material respects and that the same are
incorporated herein and made a part hereof by reference.

     2.  Defined Terms. Capitalized terms used herein and not otherwise defined
         -------------
shall have the meanings ascribed to them in the Credit Agreement.

     3.  Grant of Security Interest. The New Borrower hereby assigns, pledges
         --------------------------
and grants to the Lender, and agrees that the Lender shall have a perfected and
continuing security interest

                                       2
<PAGE>

in, and lien on, all of the New Borrower's Collateral. The New Borrower
individually represents and warrants to the Lender that its principal place of
business and the addresses where the Collateral is kept is as set forth on
Schedule 3.23 attached hereto.
-------------

     4.  Assumption of Obligations. The New Borrower promises and agrees to
         -------------------------
perform each and all of the covenants, agreements and obligations in the Credit
Documents to be performed by the Original Borrowers, at the times, in the manner
and in all respects as provided therein, and to be bound by each and all of the
terms and provisions of the Credit Agreement as though the Credit Agreement had
originally been jointly and severally made by the Original Borrowers and the New
Borrower. All of the Borrowers shall remain liable for the performance of each
and all of the covenants, agreements and obligations in the Credit Documents to
be performed by the Borrowers. All references in the Credit Agreement and in any
of the Credit Documents to the "Borrower", the "Borrowers" or the "Obligors"
shall hereafter be deemed to include the New Borrower.

     5.  Consent to Facilities Group Spin Off. The Lender hereby waives any
         ------------------------------------
default or Event of Default occurring under Sections 5.07, 5.10 or 5.12 of the
Credit Agreement occurring solely as the result of the Facilities Group Spin
Off.  The parties acknowledge and agree that the Collateral sold to the New
Borrower pursuant to the Facilities Group Spin Off is and remains subject to the
security interests in the Collateral previously granted to the Lender under the
Credit Agreement.

     6.  Representations and Warranties. The New Borrower hereby issues, makes,
         ------------------------------
ratifies and confirms the representations, warranties and covenants contained in
the Credit Documents as of the date hereof, and further represents, warrants and
covenants to the Lender as follows:

                                       3
<PAGE>

          (a)  Good Standing. The New Borrower (a) is a corporation duly
               -------------
organized, existing and in good standing under the laws of the jurisdiction of
its creation, (b) has the power to own its property and to carry on its business
as now being conducted, and (c) is duly qualified to do business and is in good
standing in each jurisdiction in which the character of the properties owned by
it therein or in which the transaction of its business makes such qualification
necessary.

          (b)  Power and Authority. The New Borrower has full power and
               -------------------
authority to execute and deliver this Agreement and each of the other Credit
Documents executed and delivered by it, to make the borrowing hereunder, and to
incur the Obligations, all of which have been duly authorized by all proper and
necessary corporate or company action. No consent or approval of stockholders or
of any public authority is required as a condition to the validity or
enforceability of this Agreement or any of the other Credit Documents executed
and delivered by the New Borrower.

          (c)  Binding Agreements. This Agreement and each of the other Credit
               ------------------
Documents executed and delivered by the New Borrower have been properly executed
by the New Borrower, constitute valid and legally binding obligations of the New
Borrower, and are fully enforceable against the New Borrower in accordance with
their respective terms.

          (d)  Litigation. There are no proceedings pending or, so far as the
               ----------
New Borrower knows, threatened before any court or administrative agency which
will materially adversely affect the financial condition or operations of the
New Borrower, or the authority of any Borrower to enter into this Agreement or
any of the other Credit Documents executed and delivered by the New Borrower.

                                       4
<PAGE>

          (e)  No Conflicting Agreements. There is (a) no charter, by-law, or
               -------------------------
preference stock provision of the New Borrower and no provision of any existing
mortgage, indenture, contract or agreement binding on the New Borrower or
affecting its property, and (b) to the knowledge of the New Borrower, no
provision of law or order of court binding upon the New Borrower, which would
conflict with or in any way prevent the execution, delivery, or performance of
the terms of this Agreement or of any of the other Credit Documents executed and
delivered by the New Borrower or which would be violated as a result of such
execution, delivery or performance.

          (f)  Wholly Owned Subsidiary.  New Borrower is a wholly owned
               -----------------------
subsidiary of EHI.

     7.   Solvency. The Borrowers represent that the fair saleable value of the
          --------
Borrowers' assets taken as a whole (including goodwill minus disposition costs)
exceeds the fair value of their liabilities; that no Borrowers are left with
unreasonably small capital after the transactions contemplated by this
Agreement; and the Borrowers are able to pay their debts (including trade debts)
as they mature.

     8.   Revised Schedules. From and after the effective date hereof, Schedules
          -----------------
3.05, 3.09, 3.10, 3.11, 3.12, 3.13, 3.14, 3.16, 3.17, 3.18, 3.19, 3.20, 3.21,
3.22, 3.23, 3.24, 3.25, 3.25A, 3.26, 3.35, 3.39 and 3.43 of the Credit Agreement
are being replaced in their entirety with the Schedules of corresponding number
attached hereto.

     9.   Conditions Precedent. This Agreement shall become effective on the
          --------------------
date the Lender receives the following documents, each of which shall be
satisfactory in form and substance to the Lender:

                                       5
<PAGE>

          (a)  The Amended and Restated Promissory Note (the "Restated Seller
Note") issued and delivered by the Borrowers in the form of Exhibit A attached
                                                            ---------
hereto and incorporated herein by reference, payable to the order of the Lender
in the original principal amount of $18,000,000.

          (b)  All documents and instruments (including, without limitation,
UCC-1 and UCC-3 Statements) required to be filed, registered or recorded in
order to create in favor of the Lender a perfected first lien in the New
Borrower's Collateral (subject only to Permitted Liens) in form and in
sufficient number for filing, registration, and recording in each office in each
jurisdiction in which such filings, registrations and recordations are required,
together with such evidence as the Lender may deem satisfactory that all
necessary filing fees and all recording and other similar fees and all taxes and
other expenses related to such filings, registrations and recordings will be or
have been paid in full.

          (c)  The Lender shall have received a Certificate dated as of the date
hereof by the Secretary or Assistant Secretary of the New Borrower covering:

               (i)   true and complete copies of the New Borrower's corporate
charter and by-laws and all amendments thereto;

               (ii)  true and complete copies of the resolutions of the New
Borrower's Board of Directors authorizing (i) the execution, delivery and
performance of the Credit Documents, (ii) the borrowing by the New Borrower
under the Credit Agreement, and (iii) the granting of the Liens contemplated by
this Agreement and any of the Credit Documents to which the New Borrower is a
party; and

                                       6
<PAGE>

               (iii)  the incumbency, authority and signatures of the officers
of the New Borrower authorized to sign this Agreement and the other Credit
Documents to which the New Borrower is a party.

          (d)  Such other information, instruments, opinions, documents,
certificates and reports as the Lender may deem necessary.

          (e)  Pursuant to Section 4.12 of the Credit Agreement, Lender shall
have received payment of its attorneys' fees incurred in connection with the
preparation, review, negotiation and execution of this Agreement and of all
other instruments, certificates and documents related hereto or executed in
connection herewith.

     10.  Replacement Seller Note. The Borrowers shall execute and deliver to
          -----------------------
the Lender on the date hereof the Restated Seller Note in substitution for, and
not satisfaction of, the issued and outstanding Seller Note, and the Restated
Seller Note shall be the "Seller Note" for all purposes of the Credit Documents.
The Seller Note being substituted pursuant to this Agreement shall be marked
"Replaced" and returned to the Borrowers after the execution and delivery of the
Restated Seller Note to the Lender.

     11.  Counterparts. This Agreement may be executed in any number of
          ------------
duplicate originals or counterparts, each of which duplicate original or
counterpart shall be deemed to be an original and all taken together shall
constitute one and the same instrument.

     12.  Credit Documents; Governing Law; Etc. This Agreement is one of the
          ------------------------------------
Credit Documents defined in the Credit Agreement and shall be governed and
construed in accordance with the laws of the Commonwealth of Virginia. The
headings and captions in this Agreement are for the convenience of the parties
only and are not a part of this Agreement.

                                       7
<PAGE>

     13.  Acknowledgments. The Borrowers hereby confirm to the Lender the
          ---------------
enforceability and validity of each of the Credit Documents. In addition, the
Borrowers hereby agree to the execution and delivery of this Agreement and the
terms and provisions, covenants or agreements contained in this Agreement shall
not in any manner release, impair, lessen, modify, waive or otherwise limit the
liability and obligations of the Borrowers under the terms of any of the Credit
Documents, except as otherwise specifically set forth in this Agreement. The
Borrowers issue, ratify and confirm the representations, warranties and
covenants contained in the Credit Documents.

     14.  Modifications. This Agreement may not be supplemented, changed,
          -------------
waived, discharged, terminated, modified or amended, except by written
instrument executed by the parties.

     15.  Full Force and Effect. Except as expressly set forth above, the
          ---------------------
provisions of the Credit Agreement shall continue in full force and effect and
are hereby ratified and confirmed. A default under this Agreement shall be a
default under the Credit Agreement.

     IN WITNESS WHEREOF the parties hereto have signed and sealed this Agreement
on the day and year first above written.

                                        LENDER:

WITNESS:                                APPLIED BIOSCIENCE INTERNATIONAL INC.

 /s/ Joanne H. Teague                    By:  /s/ Fred B. Davenport, Jr.  (SEAL)
--------------------------                  ------------------------------
                                             Name:  Fred B, Davenport, Jr.
                                                  ------------------------     .
                                             Title: Vice President
                                                   -----------------------     .

                                       8
<PAGE>

                                      BORROWERS:

                                      ENVIRON HOLDINGS, INC.,
                                      a Delaware corporation

 /s/ Joanne H. Teague                 By:   /s/ Joseph Highland          (SEAL)
--------------------------               --------------------------------
                                         Name:  Joseph Highland
                                              ---------------------------     .
                                         Title: Chairman, Chief Executive
                                                -------------------------
                                                Officer & Secretary
                                                -------------------------     .

                                      ENVIRON INTERNATIONAL CORPORATION,
                                      a Virginia corporation

 /s/ Joanne H. Teague                 By:   /s/ Joseph Highland          (SEAL)
--------------------------               --------------------------------
                                         Name:  Joseph Highland
                                              ---------------------------     .
                                         Title: Chairman, Chief Executive
                                                -------------------------
                                                Officer & Secretary
                                                -------------------------     .

                                      ENVIRON FACILITY SERVICES CORPORATION,
                                      a Virginia corporation

 /s/ Joanne H. Teague                 By:   /s/ Joseph Highland          (SEAL)
--------------------------               --------------------------------
                                         Name:  Joseph Highland
                                              ---------------------------     .
                                         Title: Chairman, Chief Executive
                                                -------------------------
                                                Officer & Secretary
                                                -------------------------     .

                                       9<PAGE>

                                                               Exhibit 10.157

                    AMENDED AND RESTATED PROMISSORY NOTE

$18,000,000                                              October 17, 2000

     FOR VALUE RECEIVED, ENVIRON HOLDINGS, INC., a Delaware corporation, ENVIRON
INTERNATIONAL CORPORATION, formerly known as APBI Environmental Sciences Group,
Inc., a Virginia corporation, and ENVIRON FACILITY SERVICES CORPORATION, a
Virginia corporation (collectively referred to herein as "Maker"), jointly and
severally promise to pay to the order of APPLIED BIOSCIENCE INTERNATIONAL INC.,
a Delaware corporation (herein, together with any subsequent holder of this
Note, referred to as "Payee"), in lawful money of the United States of America,
the principal sum of Eighteen Million Dollars ($18,000,000), together with
interest in arrears on the unpaid principal balance at an annual rate equal to
eight percent (8%) (the "Rate"), in the manner and subject to the terms and
conditions set forth hereinbelow. Interest shall be calculated on the basis of
actual days elapsed over a 360-day year.

     This Note is the Restated Seller Note referred to in that certain Amendment
No. 3 to Credit and Security Agreement of even date herewith by and among Maker
and Payee, which amends that certain Credit and Security Agreement by and among
Environ Holdings, Inc., Environ International Corporation and Payee dated
February 2, 1999 (as thereafter amended, modified, restated, substituted,
extended and renewed at any time and from time to time, the "Credit Agreement"),
is one of the Credit Documents referred to in the Credit Agreement, and is
subject to the terms and conditions of the Credit Agreement, which are, by this
reference, incorporated herein and made a part hereof. However, neither this
reference to the Credit Agreement nor any provision thereof shall impair the
absolute and unconditional obligation of Maker to pay the principal and interest
on this Note as herein provided. Capitalized terms used in this Note without
definition shall have the  meanings set forth in the Credit Agreement.  This
Note amends and restates in its entirety that certain Promissory Note dated
February 2, 1999, from Environ Holdings, Inc. and Environ International
Corporation to Payee in the original principal amount of $18,000,000.00 (the
"Original Note").  It is expressly agreed that the indebtedness evidenced by the
Original Note has not been extinguished or discharged by this Note and is
included in the amount due to Payee from Maker.  Maker and Payee acknowledge and
agree that the outstanding principal balance on this Note as of the date hereof
is $18,000,000.00.

     This Note is subject to subordination as set forth in the Credit Agreement.

1.  PAYMENTS

    1.1  PRINCIPAL AND INTEREST

         (a) Interest only shall be payable on this Note until January 31, 2004,
when principal shall begin to be repaid in accordance with paragraph 1.1(b)
below. Prior to January 31, 2003, accrued interest on the outstanding principal
hereunder calculated at the Rate shall be due
<PAGE>

and payable in four (4) annual installments of One Million Four Hundred Forty
Thousand Dollars ($1,440,000), each payment due and payable on January 31 for
the years 2000-2003.

          (b)     Principal shall be repaid in eight (8) annual installments of
Two Million Two Hundred Fifty Thousand Dollars ($2,250,000), each payment being
due and payable on January 31 in the years 2004-2011, together with accrued
interest on the outstanding principal hereunder calculated at the Rate. All
principal and accrued interest shall be paid in full on or before January 31,
2011 (the "Maturity Date"). Partial payments made by Maker to Payee shall be
applied in such order as Payee may determine in Payee's discretion.

     1.2  MANNER OF PAYMENT

     All payments of principal and interest on this Note shall be made by
certified or bank cashier's check to Payee at 3151 Seventeenth Street Extension,
Wilmington, NC 28412, or at such other place in the United States of America as
Payee shall designate to Maker in writing or by wire transfer of immediately
available funds to an account designated by Payee in writing. All payments shall
be made without set-off, counterclaim or deduction of any kind. If any payment
of principal or interest on this Note is due on a day which is not a Business
Day, such payment shall be due on the next succeeding Business Day, and such
extension of time shall be taken into account in calculating the amount of
interest payable under this Note. "Business Day" means any day other than a
Saturday, Sunday or legal holiday in the State of North Carolina.

     1.3  PREPAYMENT

     This Note is subject to prepayment as set forth in the Credit Agreement.

2.   DEFAULTS

     2.1  EVENTS OF DEFAULT; REMEDIES

     Upon the failure of Maker to pay when due any payment of principal or
interest on this Note which failure continues for ten (10) days after the due
date thereof, or upon the occurrence of any other Event of Default, Payee may,
at its option, (i) by written notice to Maker, declare the entire unpaid
principal balance of this Note, together with all accrued interest thereon,
immediately due and payable regardless of any prior forbearance, (ii) exercise
any and all rights and remedies available to Payee under the Credit Documents,
and (iii) exercise any and all rights and remedies available to Payee under
applicable law, including, without limitation, the rights and remedies of a
secured party under the Uniform Commercial Code ("UCC") of the State of Virginia
or the UCC of any other jurisdiction whose law may govern the perfection of the
liens and security interests granted under the Credit Documents. Payee may
impose a late charge of five percent (5%) of the amount of any installment of
principal and/or interest not paid on or before the tenth (10/th/) day after
such installment is due. After the occurrence of an Event of Default or after
the maturity date hereof, the entire principal balance hereof, together with
accrued interest, shall bear interest at the rate of eleven percent (11%) per
annum. All rights and remedies of Payee for an Event of Default, whether granted
herein or otherwise, shall be

                                       2
<PAGE>

cumulative and may be exercised singly or concurrently and/or from time to time
in Payee's discretion. Maker shall pay all reasonable costs and expenses
incurred by or on behalf of Payee in connection with Payee's exercise of any or
all of its rights and remedies under this Note, including, without limitation,
reasonable attorneys' fees and costs of collection.

     2.2  NOTICE BY MAKER

     Maker shall notify Payee in writing within five (5) days after the
occurrence of an Event of Default of which Maker acquires knowledge.

3.  MISCELLANEOUS

    3.1 WAIVER

    No waiver by Payee of any right or remedy under this Note shall be
effective unless in a writing signed by Payee. Neither the failure nor any delay
in exercising any right, power or privilege under this Note will operate as a
waiver of such right, power or privilege and no single or cumulative exercise of
any such right, power or privilege by Payee will preclude any other or further
exercise of such right, power or privilege or the exercise of any other right,
power or privilege. To the maximum extent permitted by applicable law, (a) no
claim or right of Payee arising out of this Note can be discharged by Payee, in
whole or in part, by a waiver or renunciation of the claim or right unless in a
writing, signed by Payee; (b) no waiver that may be given to Payee will be
applicable except in the specific instance for which it is given; and (c) no
notice to or demand on Maker will be deemed to be a waiver of any obligation of
Maker or of the right of Payee to take further action without notice or demand
as provided in this Note. Maker hereby waives presentment, demand, protest and
notice of dishonor and protest. Maker and all endorsers, sureties and guarantors
hereof hereby waive presentment for payment, demand, protest, notice of
nonpayment or dishonor, and any and all other notices and demands whatsoever,
and any and all defenses on the grounds of any extension of time for payment
which may be granted by Payee or any failure by Payee to assert any legal rights
available to Payee, and agree to remain bound until the entire indebtedness
evidenced by this Note is paid in full. Maker acknowledges the sufficiency and
receipt of the full consideration required of the Payee for this Note and that
this Note is the legal and binding obligation of each Maker enforceable in
accordance with its terms.

     3.2  NOTICES

     Any notice required or permitted to be given hereunder shall be given in
accordance with Section 7.08 of the Credit Agreement.

     3.3  SEVERABILITY

     If any provision in this Note is held invalid or unenforceable by any court
of competent jurisdiction, the other provisions of this Note will remain in full
force and effect. Any provision of this Note held invalid or unenforceable only
in part or degree will remain in full force and effect to the extent not held
invalid or unenforceable.

                                       3
<PAGE>

     3.4  GOVERNING LAW

     This Note will be governed by the laws of the State of Virginia without
regard to conflicts of laws principles and without regard to the location of any
Maker, any guarantor hereof, or of any properties or assets granted as security
for this Note.

     3.5  PARTIES IN INTEREST

     This Note shall bind each Maker and its successors and assigns and inure to
the benefit of Payee and its successors and assigns. No Maker may assign its
rights or obligations hereunder without the prior written consent of Payee.

     3.6  SECTION HEADINGS; CONSTRUCTION

     The headings of Sections in this Note are provided for convenience only and
will not affect its construction or interpretation. All references to "Section"
or "Sections" refer to the corresponding Section or Sections of this Note unless
otherwise specified. All words used in this Note will be construed to be of such
gender or number as the circumstances require. Unless otherwise expressly
provided, the words "hereof" and "hereunder" and similar references refer to
this Note in its entirety and not to any specific section or subsection hereof.
This Note may not be amended, changed or modified in any respect except by a
written document which has been executed by Maker and Payee.

     3.7  TIME OF THE ESSENCE

     Time is of the essence with respect to all dates and time periods set forth
in this Note.

     3.8. JOINT AND SEVERAL LIABILITY

     The obligations and liabilities of Environ Holdings, Inc., Environ
International Corporation and Environ Facility Services Corporation  are the
joint and several obligations of each of them.

     3.9  MUTUAL WAIVER OF JURY TRIAL

     Maker and Payee waive all rights to trial by jury of any claims of any kind
arising under or relating in any way to this Note or to the other Credit
Documents. Maker and Payee acknowledge that this is a waiver of a legal right
and represent to each other that these waivers are made knowingly and
voluntarily after consultation with counsel of their choice. Maker and Payee
agree that all such claims shall be tried before a judge of a court having
jurisdiction without a jury.

                                       4
<PAGE>

     IN WITNESS WHEREOF, and intending to be legally bound hereby, Maker
executes this Note under seal as of the date first written above.

WITNESS:                             ENVIRON HOLDINGS, INC.,
                                     a Delaware corporation

/s/ Margaret Breyer                  By: /s/ Joseph Highland
----------------------                   --------------------------------(SEAL)
                                         Name: Joseph Highland              .
                                               --------------------------
                                         Title: Chairman, Chief Executive
                                                Officer & Secretary
                                                --------------------------  .

                                     ENVIRON INTERNATIONAL CORPORATION,
                                     a Virginia corporation

/s/ Margaret Breyer                  By: /s/ Joseph Highland
----------------------                   ---------------------------------(SEAL)
                                         Name:  Joseph Highland
                                                --------------------------  .
                                         Title: Chairman, Chief Executive
                                                Officer & Secretary
                                                --------------------------  .

                                     ENVIRON FACILITY SERVICES CORPORATION,
                                     a Virginia corporation

/s/ Margaret Breyer                  By: /s/ Joseph Highland
----------------------                   ---------------------------------(SEAL)
                                         Name:  Joseph Highland
                                                --------------------------  .
                                         Title: Chairman, Chief Executive
                                                Officer & Secretary
                                                --------------------------  .

                                       5

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