Document:

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                                                                   EXHIBIT 10.2

                    DISTRIBUTION AGREEMENT AMENDMENT NO. 1

This is an amendment to the Distribution Agreement ("Distribution Agreement")
made and entered into on January 22, 2002 between:

SINCLAIR PHARMACEUTICALS LTD., a corporation duly organized and existing under
the laws of England having its place of business at Borough Rd, Godalming,
Surrey, United Kingdom GU7 2AB and Sinclair Pharma Srl, a corporation duly
organized and existing under the laws of Italy having its place of business at
Viale Marche, 15, 20125 Milano, Italy.  Sinclair Pharmaceuticals Ltd and
Sinclair Pharma Srl are hereinafter collectively referred to as "Company."

and

CELL PATHWAYS, INC., a corporation duly organized and existing under the laws
of Delaware having a place of business at 702 Electronic Drive, Horsham,
Pennsylvania, 19044 hereinafter referred to as "Distributor."

The Definitions set forth in Article 1 of the Distribution Agreement are used
in and control this Amendment No. 1.

This Amendment No. 1 is effective as of March 15, 2002.

The Company and Distributor have been working together under the Distribution
Agreement to have the Present Product manufactured on behalf of Company and
launched by Distributor in the United States.  As they have been working
together, they now understand that the Distribution Agreement has to be
clarified so that the respective responsibilities of the parties are
memorialized clearly for the purposes of regulatory compliance in the United
States.  Thus, the parties have agreed upon the following matters.

A.      Company has designated Michael Killeen as its U.S. agent under 21
C.F.R. Section 807.40(b), and Distributor agrees to this.  Company will notify
Distributor of any proposed change in U.S. Agent within 30 days of the change,
and Distributor shall have the right to approve any such change, which approval
shall not unreasonably be withheld. Company's U.S. Agent shall comply with the
applicable F.D.A. rules and regulations and specifically shall assist F.D.A.
(upon request) in communications with Company and its foreign manufacturer,
respond to questions concerning Present Product that are imported, and
scheduling inspections of the Company and its foreign manufacturer.  Company
shall ensure that its U.S. Agent shall reside or maintain a place of business
in U.S. To the extent that the U.S. Agent is contacted by the F.D.A. regarding
the Present Product , Company shall immediately notify Distributor of the
nature of the contact and provide Distributor copies of all correspondence
received.  Company shall provide advance notice of any F.D.A. inspection or
audit and Distributor shall be entitled to have a representative present at any
such inspection or audit.

B.      Company has listed Denise Swift as its official correspondent on F.D.A.
Form 2891, and Distributor agrees to this.  Company will notify Distributor of
any proposed change in official correspondent within 30 days of the change, and
Distributor shall have the right to approve any such change, which approval
shall not unreasonably be withheld.
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C.      Distributor is registered with FDA as a distributor of the Present
Product (F.D.A. Form 2891), and shall maintain that registration for as long as
its obligations under the Distribution Agreement remain in effect.

D.      Company has listed Present Product Gelclair with F.D.A. (FDA Form 2892)
and shall maintain that listing for as long as its obligations under the
Distribution Agreement remain in effect.

E.      To clarify Company's obligations under Section 1.16 not to modify
Specifications "without prior written agreement by the Parties," the parties
agree that Distributor should be notified reasonably in advance of making any
of proposed changes to Specifications, as well as any proposed changes to
manufacturing methods, processes, or procedures. All such changes proposed by
Company or its manufacturer shall be subject to advance written approval by the
Distributor, and such approval shall not unreasonably be withheld.  For
clarity, such changes include, but are not limited to manufacturing location;
process, equipment, and batch size; components, suppliers, grade and/or source;
testing methods, finished product composition and specifications; and packaging
and labeling changes.

F.      The parties agree that the packing specification attached (Appendix A)
shall be treated as part of Appendix A to the Distribution Agreement and be
deemed to be part of the Specifications under that agreement.

IN WITNESS WHEREOF, the Parties have executed this Amendment No. 1 in
duplicate.

Sinclair Pharmaceuticals Ltd.   Cell Pathways Incorporated
Signed by: Michael J. Flynn     Signed by: Robert J. Towarnicki

/s/                             /s/
-------------------------       -----------------------------
Position: President & CEO       Position:  President & C.E.O.
Date:  April 17, 2002           Date: April 8, 2002

Sinclair Pharma Srl
Signed by: Michael J. Flynn

Position: President

/s/
--------------------
Date: April 17, 2002

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                                  APPENDIX A

[Description of GelclairTM Master Label Form and depiction of GelclairTM
packaging materials.]

                                      3<PAGE>

                                                                   EXHIBIT 10.3

        Portions of this Exhibit have been redacted and are the subject of a
confidential treatment request filed with the Secretary of the Securities and
Exchange Commission.

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                    DISTRIBUTION AGREEMENT AMENDMENT NO. 2

This is the second amendment to the Distribution Agreement ("Distribution
Agreement") made and entered into on January 22, 2002 between:

SINCLAIR PHARMACEUTICALS LTD., a corporation duly organized and existing under
the laws of England having its place of business at Borough Rd, Godalming,
Surrey, United Kingdom GU7 2AB and Sinclair Pharma Srl, a corporation duly
organized and existing under the laws of Italy having its place of business at
Viale Marche, 15, 20125 Milano, Italy.  Sinclair Pharmaceuticals Ltd and
Sinclair Pharma Srl are hereinafter collectively referred to as "Company"

and

CELL PATHWAYS, INC., a corporation duly organized and existing under the laws
of Delaware having a place of business at 702 Electronic Drive, Horsham,
Pennsylvania, 19044 hereinafter referred to as "Distributor."

The Definitions set forth in Article 1 of the Distribution Agreement are used
in and control this Amendment No. 2.

This Amendment No. 2 is effective as of October 15, 2002.

The Company and Distributor agree that as to the order of "at least $2,000,000"
specified in Section 3.1 of the Distribution Agreement, that order shall be
satisfied by amending Distribution Agreement as follows:

        Distributor shall pay Company [  **  ] by October 31, 2002;

        Company shall deliver to Distributor [  **  ]of Present Product by
        December 31, 2002;

        Distributor shall pay Company [  **  ] by January 15, 2003;

        Company shall deliver to Distributor [  **  ]of Present Product by
        March 31, 2003, whereupon Distributor shall pay Company [  **  ]; and

        Company shall deliver to Distributor [  **  ]of Present Product by
        June 15, 2003, whereupon Distributor shall pay Company [  **  ].

Distributor shall send Company a purchase order substantially in the form
attached on or before October 31, 2002 reflecting the terms above.

The Company and Distributor further agree that Section 9.1 of the Distribution
Agreement shall be amended to allow Distributor to sublicense the GELCLAIR and
SINCLAIR marks for use on
---------------------------
[**] CONFIDENTIAL TREATMENT REQUESTED; CONFIDENTIAL PORTIONS OMITTED AND FILED
SEPERATELY WITH THE COMMISSION.
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Product that are promoted on behalf of Distributor by third parties (e.g., John
O. Butler Company under the dental Marketing Agreement between Butler and
Company dated August 16, 2002 (or amendments thereto)(Cell Pathways' file
C-1639)) in the Territory. Distributor shall oblige any sublicensee to perform
its obligations as to trademark usage in accordance with the provisions of
Article 9 of the Distribution Agreement.

IN WITNESS WHEREOF, the Parties have executed this Amendment No. 2 in
duplicate.

SINCLAIR PHARMACEUTIALS LTD.            CELL PATHWAYS INCORPORATED
Signed by: Michael J. Flynn             Signed by: Robert J. Towarnicki

/s/                                     /s/
---------------------------             ----------------------------
Position: President & C.E.O.            Position: President & C.E.O.
Date: October 15, 2002                  Date: October 15, 2002

SINCLAIR PHARMA SRI
Signed by: Michael J. Flynn

Position: President

/s/
----------------------
Date: October 15, 2002

                                      3<PAGE>
                                                                  EXHIBIT 10.4

                    DISTRIBUTION AGREEMENT AMENDMENT NO. 3

This is an amendment to the Distribution Agreement ("Distribution Agreement")
made and entered into on January 22, 2002 between:

SINCLAIR PHARMACEUTICALS LTD., a corporation duly organized and existing under
the laws of England having its place of business at Borough Rd, Godalming,
Surrey, United Kingdom GU7 2AB and Sinclair Pharma Srl, a corporation duly
organized and existing under the laws of Italy having its place of business at
Viale Marche, 15, 20125 Milano, Italy.  Sinclair Pharmaceuticals Ltd and
Sinclair Pharma Srl are hereinafter collectively referred to as "Company."

and

CELL PATHWAYS, INC., a corporation duly organized and existing under the laws
of Delaware having a place of business at 702 Electronic Drive, Horsham,
Pennsylvania, 19044 hereinafter referred to as "Distributor."

The Definitions set forth in Article 1 of the Distribution Agreement are used
in and control this Amendment No. 3.

This Amendment No. 3 is effective as of June 9, 2003.

The Distribution Agreement did not provide for the assignment by any party of
its rights or obligations under the Distribution Agreement to any other person
or company.

The parties hereto now wish to amend the Distribution Agreement to provide for
such assignment, so that Distributor may assign the Distribution Agreement to
its merger partner, OSI Pharmaceuticals Inc., and Company may assign the
Distribution Agreement to a party acquiring all or substantially all of its
business in the Products.

The parties hereto have agreed as follows:

1.      Distributor is permitted to assign the Distribution Agreement,
        including all its past, present and future rights and obligations
        thereunder, to OSI Pharmaceuticals Inc.  Such assignment shall take
        effect upon Distributor and OSI Pharmaceuticals Inc. giving written
        notification to Company of the assignment, or if appropriate, giving
        written notification to the assignee referred to in paragraph 2 below.

2.      Company is permitted to assign the Distribution Agreement, including
        all its past, present and future rights and obligations thereunder, to
        a person or company which is acquiring or has acquired all or
        substantially all of its business in the Products (such person or
        company is referred to herein as the "Purchaser").  Such assignment
        shall take effect upon Company and Purchaser giving written
        notification to OSI Pharmaceuticals Inc. of the assignment, or if
        appropriate, giving written notification to Distributor.

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IN WITNESS WHEREOF, the parties hereto have executed this Amendment No. 2 in
duplicate.

SINCLAIR PHARMACEUTICALS LTD.           CELL PATHWAYS INCORPORATED
Signed by: Michael J. Flynn             Signed by: Robert J. Towarnicki

/s/                                     /s/
---------------------------             ---------------------------
Position: President & C.E.O.            Position: President & C.E.O.
Date:  June 9, 2003                     Date:  June 9, 2003

SINCLAIR PHARMA SRI
Signed by: Michael J. Flynn

/s/
-------------------
Position: President
Date:  June 9, 2003

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