Document:

<PAGE>

                              EMPLOYMENT AGREEMENT

         EMPLOYMENT AGREEMENT dated as of December 20, 2003 between LEONARD
OSSER (the "EXECUTIVE") and MILESTONE SCIENTIFIC INC. (The "COMPANY").

         WHEREAS, the Company presently employs the Executive as its Chief
Executive Officer; and

         WHEREAS, the Company desires to continue to retain the Executive and
the Executive desires to continue to work for the Company; and

         WHEREAS, the Company and the Executive desire to provide for the terms
and conditions of the future employment of the Executive by the Company.

         NOW, THEREFORE, in consideration of the premises and covenants herein
contained, the parties hereto agree as follows:

         1. TERM OF AGREEMENT. Subject to the terms and conditions hereof, the
Company employs the Executive and the Executive accepts such employment for the
five year period commencing January 1, 2004 and ending December 31, 2008, unless
extended or terminated as provided in Sections 2 and 7, respectively (the
"EMPLOYMENT TERM").

         2. RENEWAL. The Employment Term shall be extended for successive
one-year periods unless prior to December 1 of any year, either party notifies
the other that he or it chooses not to extend the Employment Term. By way of
example, if neither party makes an election prior to December 1, 2004 then the
Employment Term shall automatically be extended by one additional year to
December 31, 2009.

         3. DUTIES AND RESPONSIBILITIES. During the Employment Term, the
Executive shall serve as the Chief Executive Officer of the Company and as the
holder of such other senior executive positions consistent therewith as the
Board may determine. He shall report to, and be subject to, the direction of the
Company's Board of Directors with such duties and responsibilities as are
commensurate with his title and position. The Executive shall work on a full
time basis and shall devote his time, energy and attention to the business of
the Company.

<PAGE>

         4. COMPENSATION.

         (A) BASIC COMPENSATION. In payment for services to be rendered by the
Executive hereunder, the Executive shall be entitled to Basic Compensation
during the Employment Term consisting of the cash component and stock component
described below less any withholding required by law.

         (i)   The cash component shall consist of $150,000 payable monthly or
               on such more frequent schedule as the Company may elect.

         (ii)  The stock component shall consist of a stock allotment for the
               benefit of the Executive at the end of each year during the
               Employment Term (the "Annual Allotment") consisting of such
               number of shares of the Company's Common Stock (the "Shares") as
               provided in (A) below which Shares shall be issuable as provided
               in (B) below.

               (A)  The Annual Allotment for each year shall be such number of
                    Shares which, when valued at their average closing price on
                    the American Stock Exchange or on such other exchange on
                    which such Shares are then traded during the first fifteen
                    (15) trading days of the last full month of each year during
                    the Employment Term, shall equal $150,000 provided that in
                    the event that the last year during the Employment Term is
                    less than twelve (12) full months the number of shares
                    included in that year's Annual Allotment shall be based on a
                    value of $150,000 multiplied by a fraction the numerator of
                    which shall be the number of full months the Executive was
                    employed during such year and the denominator of which shall
                    be twelve (12).

               (B)  The aggregate number of Shares included in the Annual
                    Allotments shall be issued and delivered to the Executive
                    within fifteen (15) days after the expiration of the
                    Employment Term.

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               (C)  The Executive acknowledges that the Shares issuable under
                    this Section 4(a) and the Bonus Shares issuable under
                    Section 4(b) will be taken by him for investment and not for
                    distribution thereof and will not be sold or otherwise
                    disposed of in violation of the Securities Act of 1933 as
                    amended and the rules and regulations promulgated
                    thereunder.

         (b) BONUS. Executive shall be entitled to a bonus not to exceed
$300,000 each year during the Employment Term based on the Company achieving
certain threshold operating targets established by its Board of Directors for
each year during the Employment Term. For calendar year 2004 the bonus shall be
awarded based on meeting the following thresholds:

<TABLE>
<CAPTION>
                                     Target                                                  Bonus Amount
--------------------------------------------------------------------------------------     ------------------
<S>                                                                                            <C>
If the Company achieves break even cash flow operations (Cash Flow Bonus)                      $150,000

If the Company achieves net revenues of $6,250,000 (Net Revenue Bonus)                         $100,000

If the Company  achieves  break even earnings  determined in accordance  with general
accounting principles (Earnings Bonus)                                                         $ 50,000
</TABLE>

For purposes of this Agreement, operating cash flow shall mean cash flow from
operations adjusted for financial transactions plus accounts receivable
increases and less accounts payable increases. The Cash Flow Bonus and Earnings
Bonus shall be payable only to the extent that payment thereof will not reduce
operating cash flow or earnings as the case may be below break even. The
aggregate bonus earned by Executive in any year will be payable one-half (1/2)
in cash payable at the expiration of the year and one-half (1/2) by an allotment
of Shares (the "Bonus Shares") determined (based on a valuation equal to
one-half (1/2) of the Bonus Amount for such year) as provided in Section
4(a)(ii)(A) at the end of such year and issuable within 15 days after the
expiration of the Employment Term.

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<PAGE>

         (c) OPTIONS. If in any year the Executive receives an allotment of
Bonus Shares under Section 3(b) above, he shall also be entitled to receive
options to purchase two times the number of Bonus Shares included in the
allotment. The options shall be issued at the same time that the Bonus Shares
are allotted and shall be exercisable at a purchase price equal to the same
price per share used in determining the number of Bonus Shares allotted, or 110%
of that price if the Executive is the owner of 10% or more of the Company's
outstanding shares. Such options shall have a five (5) year duration and shall
vest and become exercisable to the extent of one-third (1/3) of the options
granted at the expiration of each of the first three (3) years from the date of
grant. The vested options shall be exercisable only while Executive is employed
by the Company or within thirty (30) days after any termination of employment.
The options shall contain anti-dilution protection in the event of stock
dividends and splits and such other provisions as are customary in option grants
of this kind.

         5. EXPENSES. During the Employment Term, the Executive shall be
entitled to receive prompt reimbursement for all reasonable expenses incurred by
him (in accordance with the policies and procedures established from time to
time by the Board of Directors of the Company) in performing services hereunder,
provided that such expenses are incurred and accounted for in accordance with
the policies and procedures established by the Company.

         6. OTHER BENEFITS. The Executive shall be entitled to the following
additional benefits:

         (A) Four weeks of paid vacation during each year of the term.

         (B) Paid holidays in accordance with the Company's usual holiday
schedule plus eight additional paid holiday, or personal days, to be taken at
such time as the Executive determines.

         (C) Such major medical, family health and dental coverage benefits and
long-term disability group plan coverage generally available to the Company's
officers. To the extent the Executive qualifies, the Executive may participate
in, or benefit under, any employee benefit plan, arrangement or perquisite made
available by the Company to its key executives.

         (D) The Company shall reimburse the Executive for such ordinary and
necessary business related expenses as shall be incurred by the Executive in the
course of the performance of his duties under this Agreement.

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         (e) A monthly car allowance in the amount of the monthly rental cost of
a domestic luxury sedan or its equivalent plus expenses for business use.

         7. TERMINATION. The Executive's employment hereunder may be terminated
under the following circumstances:

         (A) The Company shall have the right to terminate the employment of the
Executive under this Agreement for disability in the event the Executive suffers
an injury, or physical or mental illness or incapacity of such character as to
substantially disable him from performing his duties hereunder for a period of
more than one hundred eighty (180) consecutive days upon the Company giving at
last thirty (30) days written notice of termination; provided, however, that if
the Executive is eligible to receive disability payments pursuant to a
disability insurance policy or policies paid for by the Company, the Executive
shall assign such benefits to the Company for all periods as to which he is
receiving payment under this Agreement.

         (B) This Agreement shall terminate upon the death of Executive.

         (C) The Company may terminate this Agreement at any time because of (i)
Executive's material breach of any term of this Agreement or (ii) the willful
engaging by the Executive in misconduct which is materially injurious to the
Company, monetarily or otherwise; provided, in each case, however, that the
Company shall not terminate this Agreement pursuant to this Section 7(c) unless
the Company shall first have delivered to the Executive a notice which
specifically identifies such breach or misconduct, specifies reasonable
corrective action and the Executive shall not have cured the breach or corrected
the misconduct within fifteen (15) days after receipt of such notice.

         (D) The Executive may terminate his employment for "Good Reason" on
five days written notice if:

         (i)   he is assigned, without his express written consent, any duties
               inconsistent with his positions, duties, responsibilities,
               authority and status with the Company as of the date hereof, or a
               change in his reporting responsibilities or titles as in effect
               as of the date hereof, except in connection with the termination
               of his employment by him without Good Reason; or

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         (ii)  his compensation is reduced or

         (iii) any purchaser or purchasers of substantially all of the business
               or assets of the Company do not agree, at or prior to the closing
               of any such transaction, by agreement in form and substance
               satisfactory to the Executive to perform this Agreement in the
               same manner and to the same extent that the Company would be
               required to perform if no sale was consummated.

         8. NONDISCLOSURE; NONCOMPETITION.

         (A) The Executive agrees not to use or disclose, either while in the
Company's employ or at any time thereafter, except with the prior written
consent of the Board of Directors, any trade secrets, proprietary information,
or other information that the Company considers confidential relating to
processes, suppliers (including but not limited to a list or lists of
suppliers), customers (including but not limited to a list or lists of
customers), compositions, improvements, inventions, operations, processing,
marketing, distributing, selling, cost and pricing data, or master files
utilized by the Company, not presently generally known to the public, and which
is, obtained or acquired by the Executive while in the employ of the Company.

         (B) During the Employment Term and for a period of two years
thereafter, the Executive shall not, directly or indirectly; (i) in any manner,
engage in any business which competes with any business conducted by the Company
(including any subsidiary) and will not directly or indirectly own, manage,
operate, join, control or participate in the ownership, management, operation or
control of, or be employed by or connected in any manner with any corporation,
firm or business that is so engaged (provided, however, that nothing herein
shall prohibit the Executive from owning not more than three percent (3%) of the
outstanding stock of any publicly held corporation), (ii) persuade or attempt to
persuade any employee of the Company to leave the employ of the Company or to
become employed by any other entity, or (iii) persuade or attempt to persuade
any current client or former client with leaving, or to reduce the amount of
business it does or intends or anticipates doing with the Company.

         (C) During his employment with the Company, and for two years
thereafter, the Executive shall not take any action which might divert from the
Company any opportunity learned about by him

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during his employment with the Company (including without limitation during the
Employment Term) which would be within the scope of any of the businesses then
engaged in or planned to be engaged in by the Company.

         (D) In the event that this Agreement shall be terminated, then
notwithstanding such termination, the obligations of Executive pursuant to this
Section 8 of this Agreement shall survive such termination.

         9. SUCCESSORS; BINDING AGREEMENT.

         (A) The Company shall require any purchaser or purchasers of the
Company or any purchaser or purchasers of substantially all of the business or
assets of the Company, by agreement in form and substance satisfactory to the
Executive, to assume and agree to perform this Agreement in the same manner and
to the same extent that the Company would be required to perform it if no such
purchase had taken place. As used in this Agreement, "Company" shall mean the
Company as hereinbefore defined and any successor to its business or assets
which executes and delivers the agreement provided for in this Section 9(a) or
which otherwise becomes bound by all the terms and provisions of this Agreement
by operation of law.

         (B) This agreement shall inure to the benefit of and be enforceable by
the Executive's personal or legal representatives, executors, administrators,
successors, heirs, distributees, devisees and legatees. If the Executive should
die while any amount would still be payable hereunder if the Executive had
continued to live, all such amounts, unless otherwise provided herein, shall be
paid in accordance with the terms of this Agreement to your devisee, legatee or
other designee or, if there be no such designee, to the Executive's estate.

         10. AMENDMENT; WAIVER. No provisions of this Agreement may be modified,
supplemented, waived or discharged unless such waiver, modification or discharge
is agreed to in writing signed by the Executive and the Company. No waiver by
either party hereto at any time of any breach by the other party hereto of, or
compliance with, any condition or provision of this Agreement to be performed by
such other party shall be deemed a waiver of similar or dissimilar provisions or
conditions at the same or at any prior or subsequent time. No agreements or
representations, oral or

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otherwise, express of implied, with respect to the subject matter hereof have
been made by either party which are not set forth expressly in this Agreement.

         11. APPLICABLE LAW. The validity, interpretation, construction and
performance of this Agreement shall be governed by the laws of the State of New
Jersey without regard to its conflict of laws principles.

         12. SEVERABILITY OF COVENANTS. In the event that any provision of this
Agreement, including any sentence, clause or part hereof, shall be deemed
contrary to law or invalid or unenforceable in any respect by a court of
competent jurisdiction, the remaining provisions shall not be affected, but
shall remain in full force and effect and any invalid and enforceable provisions
shall be deemed, without further action on the part of the undersigned,
modified, amended and limited solely to the extent necessary to render the same
valid and enforceable.

         13. REMEDIES.

         (A) In the event of a breach or threatened breach of any of the
Executive's covenants under Section 8, the Executive acknowledges that the
Company will not have an adequate remedy at law. Accordingly, in the event of
any such breach or threatened breach, the Company will be entitled to such
equitable and injunctive relief as may be available to restrain the Executive
from the violation of the provisions thereof.

         (B) Nothing herein shall be construed as prohibiting the Company, on
the one hand, and the Executive, on the other hand, from pursuing any remedies
available at law or in equity for any breach or threatened breach of the
provisions of this Agreement by the other party, including the recovery of
damages.

         (C) If the Executive terminates his employment for a Good Reason (as
defined above in Section 7(d)) then the Executive will suffer damages which will
be difficult to calculate. Consequently, the Executive shall be entitled by way
of liquidated damages, and not as a penalty, to receive a lump sum payment in an
amount equal to the amount of the compensation payments that, but for his
termination of employment, would have been payable to the Executive under
Section 4(a) for the remainder of the Employment Term. Such payment shall be
made by the Company to the

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Executive within fifteen (15) days following his termination of employment. The
Executive shall not be required to mitigate the amount of any payment received
pursuant to this paragraph nor shall the amount payable under this paragraphbe
reduced by any compensation earned by the Executive after the date of his
termination of employment.

         14. NOTICES. Any notice, request, instruction or other document to be
given hereunder by any party to the other party shall be in writing and shall be
deemed to have been duly given when delivered personally or five (5) days after
dispatch by registered or certified mail, postage prepaid, return receipt
requested, to the party to whom the same is so given or made:

         If to the Company
            addressed to:           Milestone Scientific Inc.
                                            220 South Orange Avenue
                                            Livingston Corporate Park
                                            Livingston, New Jersey 07039

         with a copy to:            Morse, Zelnick, Rose & Lander, LLP
                                            405 Park Avenue
                                            New York, New York 10022

                                            -----------------

         If to the Executive
            addressed to:           Mr. Leonard Osser
                                    110 East 71st Street
                                            New York, NY 10021

or to such other address as the one party shall specify to the other party in
writing.

         15. ENTIRE AGREEMENT. This Agreement sets forth the entire agreement of
the parties hereto in respect of the subject matter contained herein and
supersedes all prior agreements, promises, covenants, arrangements,
communications, representations or warranties, whether oral or written, by any
officer, employee or representative of any party hereto; and any prior agreement
of the parties hereto in respect of the subject matter contained herein is
hereby terminated and canceled. IN WITNESS WHEREOF, the parties have executed
this Agreement on the date and year first above written.

                                    MILESTONE SCIENTIFIC INC.

                                    BY: /s/ Stuart Wildhorn
                                        --------------------------------------
                                            STUART WILDHORN, PRESIDENT

                                        /s/ Leonard Osser
                                        --------------------------------------
                                            LEONARD OSSER

                                       9<PAGE>

                                                                    Exhibit 10.4

                 THIRD AMENDMENT TO FOURTH AMENDED AND RESTATED
                           REVOLVING CREDIT AGREEMENT

         THIRD AMENDMENT TO FOURTH AMENDED AND RESTATED REVOLVING CREDIT
AGREEMENT, dated as of July 25, 2003 (this "Third Amendment"), with respect to
the Fourth Amended and Restated Revolving Credit Agreement dated as of August
20, 2001, as amended by the First Amendment dated as of November 16, 2001, and
the Second Amendment dated as of September 18, 2002 (the "Credit Agreement"),
among Comerica Bank and the other financial institutions from time to time
parties thereto (individually, a "Lender", and collectively, "Lenders"),
Comerica Bank, as Agent for the Lenders (in such capacity, "Agent"), Plastipak
Holdings, Inc., a Michigan corporation ("Holdings"), Plastipak Packaging, Inc.,
a Delaware corporation, Whiteline Express, Ltd., a Delaware corporation, TABB
Realty, LLC, a Michigan limited liability company, and Clean Tech, Inc., a
Michigan corporation ("Borrowers"), and Plastipak Packaging do Brazil, Ltda, a
limited liability quota company organized under the laws of Brazil ("Plastipak
Brazil").

                              W I T N E S S E T H:

         WHEREAS, the Lenders, the Agent, the Borrowers, Holdings and Plastipak
Brazil are parties to the Credit Agreement; and

         WHEREAS, the Borrowers have requested the Agent and the Lenders amend
the Credit Agreement to increase the permitted Capital Expenditures; and

         WHEREAS, the Agent and the Lenders are willing to amend the Credit
Agreement on the terms and conditions provided herein;

         NOW, THEREFORE, in consideration of the mutual agreements contained
herein, it is hereby agreed as follows:

                     ARTICLE I -- DEFINITIONS AND AMENDMENTS

         1.1      Defined Terms. Capitalized terms used herein which are defined
in the Credit Agreement are used herein with such defined meanings.

         1.2      Amendment to Section 8.14. Section 8.14 is amended to read in
its entirety as follows:

         "8.14 Limitation on Capital Expenditures. Make or commit to make (by
way of the acquisition of securities of a Person or otherwise) any Capital
Expenditure, except for Capital Expenditures not to exceed the following amount
in any Fiscal Year:

                                       1
<PAGE>

                                                                    Exhibit 10.4

<TABLE>
<CAPTION>
        FISCAL YEAR                 AMOUNT
---------------------------------------------
<S>                              <C>
2003                             $148,000,000
---------------------------------------------
2004                             $110,000,000
---------------------------------------------
2005                             $ 76,000,000
---------------------------------------------
2006 and each year thereafter    $ 66,500,000
---------------------------------------------
</TABLE>

In addition, the difference between permitted Capital Expenditures and actual
Capital Expenditures at the end of any Fiscal Year and for the year then ended
may be spent during the following Fiscal Year, provided that any amounts carried
forward pursuant to this paragraph shall expire at the end of such following
Fiscal Year."

                  ARTICLE II -- REPRESENTATIONS AND WARRANTIES;
                              CONDITIONS PRECEDENT

         2.1      Representations; No Default. On and as of the effective date
hereof and after giving effect to this Third Amendment and to the transactions
contemplated hereby, Holdings and each Borrower hereby (i) confirms, reaffirms
and restates the representations and warranties set forth in Section 6 of the
Credit Agreement, except to the extent that such representations and warranties
relate solely to an earlier date in which case Holdings and each Borrower hereby
confirms, reaffirms and restates such representations and warranties on and as
of such earlier date, provided that the references to the Credit Agreement
therein shall be deemed to be references to the Credit Agreement as amended by
this Third Amendment, and (ii) represents and warrants that no Default or Event
of Default has occurred and is continuing.

         2.2      Effective Date. This Third Amendment shall become effective
when (a) the Agent shall have received counterpart originals of this Third
Amendment, in each case duly executed and delivered by Holdings, the Borrowers,
Plastipak Brazil, and the Majority Lenders and (b) Borrowers shall have paid to
the Agent for the benefit of each Lender, which shall have executed this Third
Amendment on or before 5:00 p.m. (Detroit time) on July 25, 2003, a
non-refundable amendment fee in an amount equal to the product of (i) seven and
one-half (7-1/2) basis points and (ii) such Lender's Percentage.

                           ARTICLE III-- MISCELLANEOUS

         3.1      Limited Effect. Except as expressly amended hereby, all of the
provisions, covenants, terms and conditions of the Credit Agreement shall
continue to be, and shall remain, in full force and effect in accordance with
its terms.

         3.2      Expenses. The Borrowers shall reimburse the Agent for all of
its reasonable costs and expenses including, without limitation, legal expenses,
incurred in connection with the preparation, execution and delivery of this
Third Amendment.

         3.3      Governing Law. This Third Amendment shall be governed by, and
construed and interpreted in accordance with, the law of the State of Michigan.

         3.4      Counterparts. This Third Amendment may be executed by one or
more parties hereto on any number of separate counterparts, and all of said
counterparts taken together shall be deemed to constitute one and the same
instrument.

         3.5      Guarantors. By its execution hereof, Holdings and each of the
Borrowers consents to the foregoing amendments and reaffirms and ratifies all of
its obligations to the Agent and the Lenders under the Guaranty.

                                       2
<PAGE>

                                                                    Exhibit 10.4

         IN WITNESS WHEREOF, the parties hereto have caused this Third Amendment
to be executed and delivered by their proper and duly authorized officers or
other representatives as of the date first above written.

                                      HOLDINGS:

                                      PLASTIPAK HOLDINGS, INC.

                                      By: /s/ Michael J. Plotzke
                                          --------------------------------------

                                      Its: Treasurer

                                      BORROWERS:

                                      PLASTIPAK PACKAGING, INC.

                                      By: /s/ Michael J. Plotzke
                                          --------------------------------------

                                      Its: Treasurer

                                      WHITELINE EXPRESS, LTD.

                                      By: /s/ Michael J. Plotzke
                                          --------------------------------------

                                      Its: Treasurer

                                      TABB REALTY, LLC

                                      By: /s/ Michael J. Plotzke
                                          --------------------------------------

                                      Its: Treasurer

                                      CLEAN TECH, INC.

                                      By: /s/ Michael J. Plotzke
                                          --------------------------------------

                                      Its: Treasurer

                                      PLASTIPAK BRAZIL:

                                      PLASTIPAK PACKAGING DO BRAZIL,
                                      LTDA

                                      By: /s/ Marcelo B. Gianesi
                                          --------------------------------------

                                       3
<PAGE>

                                                                    Exhibit 10.4

                                      Its: Administrative Manager

                                      AGENT AND LENDERS:

                                      COMERICA BANK, as Agent and as a Lender

                                      By: /s/ Jeffrey J. Judge
                                          --------------------------------------

                                      Its: Vice President

                                      STANDARD FEDERAL BANK

                                      By: /s/ Gregory Castle
                                          --------------------------------------

                                      Its: First Vice President

                                      FLEET NATIONAL BANK

                                      By: /s/ Marwan Isbaih
                                          --------------------------------------

                                      Its: Director

                                      NATIONAL CITY BANK

                                      By: /s/ Kenneth M. Blackwell
                                          --------------------------------------

                                      Its: Vice President

                                      BANK ONE, MICHIGAN

                                      By: /s/ Mark L. McClure
                                          --------------------------------------

                                      Its: First Vice President

                                      ASSOCIATED BANK, N.A.

                                      By: /s/ Joseph J. Gehrke
                                          --------------------------------------

                                      Its: Vice President

                                       4
<PAGE>

                                                                    Exhibit 10.4

                                      FIRSTMERIT BANK, N.A.

                                      By: /s/ Kathryn B. Nielsen
                                          --------------------------------------

                                      Its: Vice President

                                      MARINE BANK

                                      By: /s/ William E. Shaw
                                          --------------------------------------

                                      Its: Senior Vice President

                                       5

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