Document:

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                               NEUROMEDICA, INC.

            1992 EMPLOYEE, DIRECTOR AND CONSULTANT STOCK OPTION PLAN

1. DEFINITIONS.

     Unless otherwise specified or unless the context otherwise requires, the
following terms, as used in this Neuromedica, Inc. 1992 Employee, Director and
Consultant Stock Option Plan, have the following meanings:

          ADMINISTRATOR means the Board of Directors, unless it has delegated
     power to act on its behalf to a committee. (See Article 4)

          AFFILIATE means a corporation which, for purposes of Section 424 of
     the Code, is a parent or subsidiary of the Company, direct or indirect.

          BOARD OF DIRECTORS means the Board of Directors of the Company.

          CODE means the United States Internal Revenue Code of 1986, as
     amended.

          COMMITTEE means the Committee to which the Board of Directors has
     delegated power to act under or pursuant to the provisions of the Plan.

          COMMON STOCK means shares of the Company's common stock, $.01 par
     value.

          COMPANY means Neuromedica, Inc. a Massachusetts corporation.

          DISABILITY or DISABLED means permanent and total disability as defined
     in Section 22(e)(3) of the Code.

          FAIR MARKET VALUE of a Share of Common Stock means:

               (1) If the Common Stock is listed on a national securities
          exchange or traded in the over-the-counter market and sales prices are
          regularly reported for the Common Stock, the average of the closing or
          last prices of the Common Stock on the Composite Tape or other
          comparable reporting system for the ten (10)

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          consecutive trading days immediately preceding the applicable date;

               (2) If the Common Stock is not traded on a national securities
          exchange but is traded on the over-the-counter market, if sales prices
          are not regularly reported for the Common Stock for the ten (10) days
          referred to in clause (1), and if bid and asked prices for the Common
          Stock are regularly reported, the average of the mean between the bid
          and the asked price for the Common Stock at the close of trading in
          the over-the-counter market for the ten (10) days on which Common
          Stock was traded immediately preceding the applicable date; and

               (3) If the Common Stock is neither listed on a national
          securities exchange nor traded in the over-the-counter market, such
          value as the Administrator, in good faith, shall determine.

          ISO means an option meant to qualify as an incentive stock option
     under Code Section 422.

          KEY EMPLOYEE means an employee of the Company or of an Affiliate
     (including, without limitation, an employee who is also serving as an
     officer or director of the Company or of an Affiliate), designated by the
     Administrator to be eligible to be granted one or more Options under the
     Plan.

          NON-QUALIFIED OPTION means an option which is not intended to qualify
     as an ISO.

          OPTION means an ISO or Non-Qualified Option granted under the Plan.

          OPTION AGREEMENT means an agreement between the Company and a
     Participant executed and delivered pursuant to the Plan.

          PARTICIPANT means a Key Employee, director or consultant to whom one
     or more Options are granted under the Plan. As used herein, "Participant"
     shall include "Participant's Survivors" where the context requires.

          PARTICIPANT'S SURVIVORS means a deceased Participant's legal
     representative and/or any person or persons who acquired the Participant's
     rights to an Option by will or by the laws of descent and distribution.

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          PLAN means this Neuromedica, Inc. 1992 Employee, Director and
     Consultant Stock Option Plan.

          SHARES means shares of the Common Stock as to which Options have been
     or may be granted under the Plan or any shares of capital stock into which
     the Shares are changed or for which they are exchanged within the
     provisions of Paragraph 3 of the Plan. The Shares issued upon exercise of
     Options granted under the Plan may be authorized and unissued shares or
     shares held by the Company in its treasury, or both.

2. PURPOSES OF THE PLAN.

     The Plan is intended to encourage ownership of Shares by Key Employees,
directors and certain consultants to the Company in order to attract such
people, to induce them to work for the benefit of the Company or of an Affiliate
and to provide additional incentive for them to promote the success of the
Company or of an Affiliate. The Plan provides for the issuance of ISOs and
Non-Qualified Options.

3. SHARES SUBJECT TO THE PLAN.

     The number of Shares subject to this Plan as to which Options may be
granted from time to time shall be [Number of Shares], or the equivalent of
such number of Shares after the Administrator, in its sole discretion, has
interpreted the effect of any stock split, stock dividend, combination,
recapitalization or similar transaction in accordance with Paragraph 16 of
the Plan.

     If an Option ceases to be "outstanding", in whole or in part, the Shares
which were subject to such Option shall be available for the granting of
other Options under the Plan. Any Option shall be treated as "outstanding"
until such Option is exercised in full, or terminates or expires under the
provisions of the Plan, or by agreement of the parties to the pertinent
Option Agreement.

4. ADMINISTRATION OF THE PLAN.

     The Administrator of the Plan will be the Board of Directors, except to the
extent the Board of Directors delegates its authority to a Committee of the
Board of Directors. Following the date on which the Common Stock is registered
under the Securities and Exchange Act of 1934, as amended (the "1934 Act"), the
Plan is intended to comply in all respects with Rule

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16b-3 or its successors, promulgated pursuant to Section 16 of the 1934 Act with
respect to Participants who are subject to Section 16 of the 1934 Act, and any
provision in this Plan with respect to such persons contrary to Rule 16b-3 shall
be deemed null and void to the extent permissible by law and deemed appropriate
by the Administrator. Subject to the provisions of the Plan, the Administrator
is authorized to:

     a.   Interpret the provisions of the Plan or of any Option or Option
          Agreement and to make all rules and determinations which it deems
          necessary or advisable for the administration of the Plan;

     b.   Determine which employees of the Company or of an Affiliate shall be
          designated as Key Employees and which of the Key Employees, directors
          and consultants shall be granted Options;

     c.   Determine the number of Shares for which an Option or Options shall be
          granted; and

     d.   Specify the terms and conditions upon which an Option or Options may
          be granted;

provided, however, that all such interpretations, rules, determinations, terms
and conditions shall be made and prescribed in the context of preserving the tax
status under Code Section 422 of those Options which are designated as ISOs.
Subject to the foregoing, the interpretation and construction by the
Administrator of any provisions of the Plan or of any Option granted under it
shall be final, unless otherwise determined by the Board of Directors, if the
Administrator is other than the Board of Directors.

5. ELIGIBILITY FOR PARTICIPATION.

     The Administrator will, in its sole discretion, name the Participants in
the Plan, provided, however, that each Participant must be a Key Employee,
director or consultant of the Company or of an Affiliate at the time an
Option is granted. Notwithstanding any of the foregoing provisions, the
Administrator may authorize the grant of an Option to a person not then an
employee, director or consultant of the Company or of an Affiliate. The
actual grant of such Option, however, shall be conditioned upon such person
becoming eligible to become a Participant at or prior to the time of the
execution of the Option Agreement evidencing such Option. ISOs may be granted
only to Key Employees. Non-Qualified Options may be granted to any Key
Employee, director or consultant of the Company or an Affiliate. The granting
of any Option to any individual shall

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neither entitle that individual to, nor disqualify him or her from,
participation in any other grant of Options.

6. TERMS AND CONDITIONS OF OPTIONS.

     Each Option shall be set forth in writing in an Option Agreement, duly
executed by the Company and by the Participant. The Administrator may provide
that Options be granted subject to such conditions as the Administrator may deem
appropriate including, without limitation, subsequent approval by the
stockholders of the Company of this Plan or any amendments thereto. The Option
Agreements shall be subject to at least the following terms and conditions:

     A.   NON-QUALIFIED OPTIONS: Each Option intended to be a Non-Qualified
          Option shall be subject to the terms and conditions which the
          Administrator determines to be appropriate and in the best interest of
          the Company, subject to the following minimum standards for any such
          Non-Qualified Option:

          a.   Option Price: The option price (per share) of the Shares covered
               by each Option shall be determined by the Administrator but shall
               not be less than the par value per share of Common Stock.

          b.   Each Option Agreement shall state the number of Shares to which
               it pertains;

          c.   Each Option Agreement shall state the date or dates on which it
               first is exercisable and the date after which it may no longer be
               exercised, and may provide that the Option rights accrue or
               become exercisable in installments over a period of months or
               years, or upon the occurrence of certain conditions or the
               attainment of stated goals; and

          d.   Exercise of any Option may be conditioned upon the Participant's
               execution of a Share purchase agreement in form satisfactory to
               the Administrator providing for certain protections for the
               Company and its other shareholders including requirements that:

               i.   The Participant's or the Participant's Survivors' right to
                    sell the Shares may be restricted; and

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              ii.  The Participant or the Participant's Survivors may be
                   required to execute letters of investment intent and must
                   also acknowledge that the Shares will bear legends noting
                   any applicable restrictions.

     B.  ISOs: Each Option intended to be an ISO shall be issued only to a
         Key Employee and be subject to at least the following terms and
         conditions, with such additional restrictions or changes as the
         Administrator determines are appropriate but not in conflict with
         Code Section 422 and relevant regulations and rulings of the
         Internal Revenue Service:

         a.  Minimum standards: The ISO shall meet the minimum standards
             required of Participants who are granted Non-Qualified Options,
             as described above, except clause (a) thereunder.

         b.  Option Price: Immediately before the Option is granted, if the
             Participant owns, directly or by reason of the applicable
             attribution rules in Code Section 424(d):

             i.  Ten percent (10%) OR LESS of the total combined voting power
                 of all classes of share capital of the Company or an
                 Affiliate, the Option price (per share) of the Shares
                 covered by each Option shall not be less than one hundred
                 percent (100%) of the Fair Market Value (per share) of the
                 Shares on the date of the grant of the Option.

             ii. More than ten percent (10%) of the total combined voting
                 power of all classes of share capital of the Company or an
                 Affiliate, the Option price (per share) of the Shares
                 covered by each Option shall not be less than one hundred
                 ten percent (110%) of the said Fair Market Value on the date
                 of grant.

         c.  Term of Option: For Participants who own

             i.  Ten percent (10%) OR LESS of the total combined voting
                 power of all classes of share capital of the Company or an
                 Affiliate, each Option shall terminate not more than ten
                 (10) years from the date of the grant or at such earlier
                 time as the Option Agreement may provide;

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             ii. More than 10% of the total combined voting power of all
                 classes of share capital of the Company or an Affiliate,
                 each Option shall terminate not more than five (5) years
                 from the date of the grant or at such earlier time as the
                 Option Agreement may provide.

         d.  Medium of Payment: The Option price shall be payable upon the
             exercise of the Option and only in such form as the
             Administrator determines and as is permitted by Section 422 of
             the Code.

         e.  Limitation on Yearly Exercise: The Option Agreements shall
             restrict the amount of Options which may be exercisable in any
             calendar year (under this or any other ISO plan of the Company
             or an Affiliate) so that the aggregate Fair Market Value
             (determined at the time each ISO is granted) of the stock with
             respect to which ISOs are exercisable for the first time by the
             Participant in any calendar year does not exceed one hundred
             thousands dollars ($100,000), provided that this subparagraph
             (e) shall have no force or affect if its inclusion in the Plan
             is not necessary for Options issued as ISOs to qualify as ISOs
             pursuant to Section 422(d) of the Code.

         f.  Limitation on Grant of ISOs: No ISOs shall be granted after
             October 31, 2002, the date which is the EARLIER of ten (10)
             years from the date of the adoption of the Plan by the Company
             and the date of the approval of the Plan by the shareholders of
             the Company.

7.  EXERCISE OF OPTION AND ISSUE OF SHARES.

    An Option (or any part or installment thereof) shall be exercised by
giving written notice to the Company at its principal office address,
together with provision for payment of the purchase price in accordance with
this paragraph for the shares as to which such Option is being exercised, and
upon compliance with any other condition(s) set forth in the Option
Agreement. Such written notice shall be signed by the person exercising the
Option, shall state the number of Shares with respect to which the Option is
being exercised and shall contain any representation required by the Plan or
the Option Agreement. Full payment of the purchase price for the Shares as to
which such Option is being exercised shall be made (a) in United States
dollars in cash or by check, or (b) at the discretion of the Administrator,
through delivery of shares of Common Stock having

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a fair market value equal as of the date of the exercise to the cash exercise
price of the Option, determined in good faith by the Administrator, or (c) at
the discretion of the Administrator, by delivery of the grantee's personal
recourse note bearing interest payable not less than annually at no less than
100% of the applicable Federal rate, as defined in Section 1274(d) of the
Code, (d) at the discretion of the Administrator in accordance with a
so-called cashless exercise plan established with a securities brokerage firm
and approved by the Administrator, or (e) at the discretion of the
Administrator, by any combination of (a), (b), (c) and (d) above.
Notwithstanding the foregoing, the Administrator shall accept only such
payment on exercise of an ISO as is permitted by Section 422 of the code.

    The Company shall then reasonably promptly deliver the Shares as to which
such Option was exercised to the Participant (or to the Participant's
Survivors, as the case may be). In determining what constitutes "reasonably
promptly," it is expressly understood that the delivery of the Shares may be
delayed by the Company in order to comply with any law or regulation which
requires the Company to take any action with respect to the Shares prior to
their issuance. The Shares shall, upon delivery, be evidenced by an
appropriate certificate or certificates for fully paid, non-assessable Shares.

    The Administrator shall have the right to accelerate the date of exercise
on any installment of any Option; provided that the Administrator shall not
accelerate the exercise date of any installment of any Option granted to any
Key Employee as an ISO (and not previously converted into a Non-Qualified
Option pursuant to paragraph 19) if such acceleration would violate the
annual vesting limitation contained in Section 422(d) of the Code, as
described in paragraph 6B.(e).

8.  RIGHTS AS A SHAREHOLDER.

    No Participant to whom an Option has been granted shall have rights as a
shareholder with respect to any Shares covered by such Option, except after
due exercise of the Option and tender of the full purchase price for the
Shares being purchased pursuant to such exercise and registration of the
Shares in the Company's share register in the name of the Participant.

9.  ASSIGNABILITY AND TRANSFERABILITY OF OPTIONS.

    By its terms, an Option granted to a Participant shall not be
transferable by the Participant other than by will or by the laws of descent
and distribution and shall be exercisable, during the Participant's lifetime,
only by such Participant (or by his

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or her legal representative). Such Option shall not be assigned, pledged or
hypothecated in any way (whether by operation of law or otherwise) and shall
not be subject to execution, attachment or similar process. Any attempted
transfer, assignment, pledge, hypothecation or other disposition of any
Option or of any rights granted thereunder contrary to the provisions of this
Plan, or the levy of any attachment or similar process upon an Option, shall
be null and void.

10. EFFECT OF TERMINATION OF SERVICE OTHER THAN "FOR CAUSE".

    Except as otherwise provided in the pertinent Option Agreement, in the
event of a termination of service (whether as an employee, director or
consultant) with the Company or an Affiliate before the Participant has
exercised all Options, the following rules apply:

    a.  A Participant who ceases to be an employee, director or consultant of
        the Company or of an Affiliate (for any reason other than termination
        "for cause", Disability, or death for which events there are special
        rules in Paragraphs 11, 12, and 13, respectively), may exercise any
        Option granted to him or her to the extent that the right to purchase
        Shares has accrued on the date of such termination of service, but
        only within such term as the Administrator has designated in the
        pertinent Option Agreement.

    b.  In no event may an Option Agreement provide, if the Option is
        intended to be an ISO, that the time for exercise be later than three
        (3) months after the Participant's termination of employment.

    c.  The provisions of this paragraph, and not the provisions of Paragraph
        12 or 13, shall apply to a Participant who subsequently becomes
        disabled or dies after the termination of employment, director status
        or consultancy, provided, however, in the case of a Participant's
        death within three (3) months after termination of employment,
        director status or consulting, the Participant's Survivors may exercise
        the Option within one (1) year after the date of the Participant's
        death, but in no event after the date of expiration of the term of
        the Option.

    d.  Notwithstanding anything herein to the contrary, if subsequent to a
        Participant's termination of employment, termination of director
        status or termination of consultancy, but prior to the exercise of an
        Option, the Board of Directors determines that,

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        either prior or subsequent to the Participant's termination, the
        Participant engaged in conduct which would constitute "cause", then
        such Participant shall forthwith cease to have any right to exercise
        any Option.

    e.  A Participant to whom an Option has been granted under the Plan who
        is absent from work with the Company or with an Affiliate because of
        temporary disability (any disability other than a permanent and total
        Disability as defined in Paragraph 1 hereof), or who is on leave of
        absence for any purpose, shall not, during the period of any such
        absence, be deemed, by virtue of such absence alone, to have
        terminated such Participant's employment, director status or
        consultancy with the Company or with an Affiliate, except as the
        Administrator may otherwise expressly provide.

    f.  Options granted under the Plan shall not be affected by any change of
        employment or other service within or among the Company and any
        Affiliates, so long as the Participant continues to be an employee,
        director or consultant of the Company or any Affiliate, provided,
        however, if a Participant's employment by either the Company or an
        Affiliate should cease (other than to become an employee of an
        Affiliate or the Company), such termination shall affect the
        Participant's rights under any Option granted to such Participant in
        accordance with the terms of the Plan and the pertinent Option
        Agreement.

11. EFFECT OF TERMINATION OF SERVICE "FOR CAUSE".

     Except as otherwise provided in the pertinent Option Agreement, the
following rules apply if the Participant's service (whether as an employee,
director or consultant) with the Company or an Affiliate is terminated "for
cause" prior to the time that all of his or her outstanding Options have been
exercised:

    a.  All outstanding and unexercised Options as of the date the Participant
        is notified his or her service is terminated "for cause" will
        immediately be forfeited, unless the Option Agreement provides
        otherwise.

    b.  For purposes of this Article, "cause" shall include (and is not
        limited to) dishonesty with respect to the employer, insubordination,
        substantial malfeasance or non-feasance of duty, unauthorized
        disclosure of confidential information, and conduct substantially

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        prejudicial to the business of the Company or any Affiliate. The
        determination of the Administrator as to the existence of cause will
        be conclusive on the Participant and the Company.

    c.  "Cause" is not limited to events which have occurred prior to a
        Participant's termination of service, nor is it necessary that the
        Administrator's finding of "cause" occur prior to termination. If the
        Administrator determines, subsequent to a Participant's termination
        of service but prior to the exercise of an Option, that either prior
        or subsequent to the Participant's termination the Participant
        engaged in conduct which would constitute "cause", then the right to
        exercise any Option is forfeited.

    d.  Any definition is an agreement between the Participant and the
        Company or an Affiliate, which contains a conflicting definition of
        "cause" for termination and which is in affect at the time of such
        termination, shall supersede the definition in this Plan with respect
        to such Participant.

12. EFFECT OF TERMINATION OF SERVICE FOR DISABILITY.

     Except as otherwise provided in the pertinent Option Agreement, a
Participant who ceases to be an employee, director or consultant of the
Company or of an Affiliate by reason of Disability may exercise any Option
granted to such Participant:

    a.  To the extent that the right to purchase Shares has accrued on the
        date of his or her Disability; and

    b.  In the event rights to exercise the Option accrue periodically, to
        the extent of a pro rata portion of any additional rights as would
        have accrued had the Participant not become Disabled prior to the end
        of the accrual period which next ends following the date of
        Disability. The proration shall be based upon the number of days of
        such accrual period prior to the date of Disability.

     A Disabled Participant may exercise such rights only within a period of
not more than one (1) year after the date that the Participant became
Disabled, notwithstanding that the Participant might have been able to
exercise the Option as to some or all of the Shares on a later date if he or
she had not become disabled and had continued to be an employee, director or
consultant or, if earlier, within the originally prescribed term of the
Option.

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     The Administrator shall make the determination both of whether Disability
has occurred and the date of its occurrence (unless a procedure for such
determination is set forth in another agreement between the Company and such
Participant, in which case such procedure shall be used for such determination).
If requested, the Participant shall be examined by a physician selected or
approved by the Administrator, the cost of which examination shall be paid for
by the Company.

13. EFFECT OF DEATH WHILE AN EMPLOYEE, DIRECTOR OR CONSULTANT.

     Except as otherwise provided in the pertinent Option Agreement, in the
event of the death of a Participant to whom an Option has been granted while the
Participant is an employee, director or consultant of the Company or of an
Affiliate, such Option may be exercised by the Participant's Survivors:

     a.   To the extent exercisable but not exercised on the date of death; and

     b.   In the event rights to exercise the Option accrue periodically, to the
          extent of a pro rata portion of any additional rights which would have
          accrued had the Participant not died prior to the end of the accrual
          period which next ends following the date of death. The proration
          shall be based upon the number of days of such accrual period prior to
          the Participant's death.

     If the Participant's Survivors wish to exercise the Option, they must take
all necessary steps to exercise the Option within one (1) year after the date of
death of such Participant, notwithstanding that the decedent might have been
able to exercise the Option as to some or all of the Shares on a later date if
he or she had not died and had continued to be an employee, director or
consultant or, if earlier, within the originally prescribed term of the Option.

14. PURCHASE FOR INVESTMENT.

     Unless the offering and sale of the Shares to be issued upon the particular
exercise of an Option shall have been effectively registered under the
Securities Act of 1933, as now in force or hereafter amended (the "1933 Act"),
the Company shall be under no obligation to issue the Shares covered by such
exercise unless and until the following conditions have been fulfilled:

     a.   The person(s) who exercise such Option shall warrant to the Company,
          prior to receipt of the Shares that such person(s) are acquiring such
          Shares for their own

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          respective accounts, for investment, and not with a view to, or for
          sale in connection with, the distribution of any such Shares, in which
          event the person(s) acquiring such Shares shall be bound by the
          provisions of the following legend which shall be endorsed upon the
          certificate(s) evidencing their Shares issued pursuant to such
          exercise or such grant:

               "The shares represented by this certificate have been taken for
               investment and they may not be sold or otherwise transferred by
               any person, including a pledgee, unless (1) either (a) a
               Registration Statement with respect to such shares shall be
               effective under the Securities Act of 1933, as amended, or (b)
               the Company shall have received an opinion of counsel
               satisfactory to it that an exemption from registration under such
               Act is then available, and (2) there shall have been compliance
               with all applicable state securities laws.

     b.   The Company shall have received an opinion of its counsel that the
          Shares may be issued upon such particular exercise in compliance with
          the 1933 Act without registration thereunder.

     The Company may delay issuance of the Shares until completion of any action
or obtaining of any consent which the Company deems necessary under any
applicable law (including, without limitation, state securities or "blue sky"
laws).

15. DISSOLUTION OR LIQUIDATION OF THE COMPANY.

     Upon the dissolution or liquidation of the Company, all Options granted
under this Plan which as of such date shall not have been exercised will
terminate and become null and void; provided, however, that if the rights of a
Participant or a Participant's Survivors have not otherwise terminated and
expired, the Participant or the Participant's Survivors will have the right
immediately prior to such dissolution or liquidation to exercise any Option to
the extent that the right to purchase Shares has accrued under the Plan as of
the date immediately prior to such dissolution or liquidation.

16. ADJUSTMENTS.

     Upon the occurrence of any of the following events, a Participant's rights
with respect to any Option granted to him or her hereunder which have not
previously been exercised in full

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shall be adjusted as hereinafter provided, unless otherwise specifically
provided in the written agreement bewteen the Participant and the Company
relating to such Option:

     A. STOCK DIVIDENDS AND STOCK SPLITS. If the shares of Common Stock shall
be subdivided or combined into a greater or smaller number of shares or if
the Company shall issue any shares of Common Stock as a stock dividend on its
outstanding Common Stock, the number of shares of Common Stock deliverable
upon the exercise of such Option shall be appropriately increased or
decreased proportionately, and appropriate adjustments shall be made in the
purchase price per share to reflect such subdivision, combination or stock
dividend.

     B. CONSOLIDATIONS OR MERGERS. If the Company is to be consolidated with
or acquired by another entity in a merger, sale of all or substantially all
of the Company's assets or otherwise (an "Acquisition"), the Administrator
or the board of directors of any entity assuming the obligations of the
Company hereunder (the "Successor Board"), shall, as to outstanding Options,
either (i) make appropriate provision for the continuation of such Options by
substituting on an equitable basis for the Shares then subject to such
Options either the consideration payable with respect to the outstanding
shares of Common Stock in connection with the Acquisition or securities of
any successor or acquiring entity; or (ii) upon written notice to the
Participants, provide that all Options must be exercised, to the extent then
exercisable, within a specified number of days of the date of such notice, at
the end of which period the Options shall terminate; or (iii) terminate all
Options in exchange for a cash payment equal to the excess of the Fair Market
Value of the shares subject to such Options (to the extent then exercisable)
over the exercise price thereof.

     C. RECAPITALIZATION OR REORGANIZATION. In the event of a
recapitalization or reorganization of the Company (other than a transaction
described in subparagraph B above) pursuant to which securities of the Company
or of another corporation are issued with respect to the outstanding shares
of Common Stock, a Participant upon exercising an option shall be entitled to
receive for the purchase price paid upon such exercise the securities he or
she would have received if he or she had exercised such Option prior to such
recapitalization or reorganization.

     D. MODIFICATION OF ISOS. Notwithstanding the foregoing, any adjustments
made pursuant to subparagraphs A, B or C with respect to ISOs shall be made
only after the Administrator, after consulting with counsel for the Company,
determines whether such adjustments would constitute a "modification" of such
ISOs (as that term is defined in Section 424(h) of the Code) or would

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cause any adverse tax consequences for the holders of such ISOs. If the
Administrator determines that such adjustments made with respect to ISOs
would constitute a modification of such ISOs, it may refrain from making such
adjustments, unless the holder of an ISO specifically requests in writing
that such adjustment be made and such writing indicates that the holder has
full knowledge of the consequences of such "modification" on his or her
income tax treatment with respect to the ISO.

17. ISSUANCES OF SECURITIES.

     Except as expressly provided herein, no issuance by the Company of shares
of stock of any class, or securities convertible into shares of stock of any
class, shall affect, and no adjustment by reason thereof shall be made with
respect to, the number or price of shares subject to Options. Except as
expressly provided herein, no adjustments shall be made for dividends paid in
cash or in property (including without limitation, securities) of the Company.

18. FRACTIONAL SHARES.

     No fractional share shall be issued under the Plan and the person
exercising such right shall receive from the Company cash in lieu of such
fractional share equal to the fair market value thereof determined in good
faith by the Board of Directors of the Company.

19. CONVERSION OF ISOs INTO NON-QUALIFIED OPTIONS; TERMINATION OF ISOs.

     The Administrator, at the written request of any Participant, may in
its discretion take such actions as may be necessary to convert such
Participant's ISOs (or any portions thereof) that have not been exercised on
the date of conversion into Non-Qualified Options at any time prior to the
expiration of such ISOs, regardless of whether the Participant is an employee
of the Company or an Affiliate at the time of such conversion. Such actions
may include, but not be limited to, extending the exercise period or reducing
the exercise price of the appropriate installments of such Options. At the
time of such conversion, the Administrator (with the consent of the
Participant) may impose such conditions on the exercise of the resulting
Non-Qualified Options as the Administrator in its discretion may determine,
provided that such conditions shall not be inconsistent with this Plan.
Nothing in the Plan shall be deemed to give any Participant the right to have
such Participant's ISO's converted into Non-Qualified Options, and no such
conversion shall occur until and unless the Administrator takes

                                     -15-

<Page>

appropriate action. The Administrator, with the consent of the Participant,
may also terminate any portion of any ISO that has not been exercised at the
time of such termination.

20. WITHHOLDING.

     Upon the exercise of a Non-Qualified Option for less than the then Fair
Market Value or the making of a Disqualifying Disposition (as defined in
paragraph 21), the Company may withhold from the Participant's wages, if any,
or other remuneration, or may require the Participant to pay additional
federal, state, and local income tax withholding and employee contributions to
employment taxes in respect of the amount that is considered compensation
includible in such person's gross income. The Administrator in its discretion
may condition the exercise of an Option for less than the then Fair Market
Value on the Participant's payment of such additional income tax withholding
and employee contributions to employment taxes.

21. NOTICE TO COMPANY OF DISQUALIFYING DISPOSITION.

     Each Key Employee who receives an ISO must agree to notify the Company
in writing immediately after the Key Employee makes a Disqualifying
Disposition of any shares acquired pursuant to the exercise of an ISO. A
Disqualifying Disposition is any disposition (including any sale) of such
shares before the later of (a) two years after the date the Key Employee was
granted the ISO, or (b) one year after the date the Key Employee acquired
shares by exercising the ISO. If the Key Employee has died before such stock
is sold, these holding period requirements do not apply and no Disqualifying
Disposition can occur thereafter.

22. TERMINATION OF THE PLAN.

     The Plan will terminate on October 31, 2002, the date which is ten (10)
years from the EARLIER of the date of its adoption and the date of its
approval by the stockholders of the Company. The Plan may be terminated at an
earlier date by vote of the stockholders of the Company; provided, however,
that any such earlier termination will not affect any Options granted or
Option Agreements executed prior to the effective date of such termination.

23. AMENDMENT OF THE PLAN.

     The Plan may be amended by the stockholders of the Company. The Plan may
also be amended by the Administrator, including,

                                       -16-
<Page>

without limitation, to the extent necessary to qualify any or all outstanding
Options granted under the Plan or Options to be granted under the Plan for
favorable federal income tax treatment (including deferral of taxation upon
exercise) as may be afforded incentive stock options under Section 422 of the
Code, to the extent necessary to ensure the qualification of the Plan under
Rule 16b-3, and to the extent necessary to qualify the shares issuable upon
exercise of any outstanding Options granted, or Options to be granted, under
the Plan for listing on any national securities exchange or quotation in any
national automated quotation system of securities dealers. Any amendment
approved by the Administrator which is of a scope that requires stockholder
approval in order to ensure favorable federal income tax treatment for any
incentive stock options or requires stockholder approval in order to ensure
the compliance of the Plan with Rule 16b-3 shall be subject to obtaining such
stockholder approval. Any modification or amendment of the Plan shall not,
without the consent of a Participant, affect his or her rights under an
Option previously granted to him or her. With the consent of the Participant
affected, the Administrator may amend outstanding Option Agreements in a manner
not inconsistent with the Plan.

24. EMPLOYMENT OR OTHER RELATIONSHIP.

     Nothing in this Plan or any Option Agreement shall be deemed to prevent
the Company or an Affiliate from terminating the employment, consultancy or
director status of a Participant, nor to prevent a Participant from
terminating his or her own employment, consultancy or director status or to
give any Participant a right to be retained in employment or other service by
the Company or any Affiliate for any period of time.

25. GOVERNING LAW.

     This Plan shall be construed and enforced in accordance with the law of
The Commonwealth of Massachusetts.

                                     -17-<PAGE>

                                                                  EXHIBIT 10.16

                               Neuromedica, Inc.

                             1997 Stock Option Plan
                    (reflects corrections approved in 2/98)

     1. DEFINITIONS. As used in this 1997 Stock Option Plan of Neuromedica,
Inc., the following terms shall have the following meanings:

          1.1. BOARD means the Company's Board of Directors.

          1.2. CODE means the federal Internal Revenue Code of 1986, as amended.

          1.3. COMMITTEE means a committee appointed by the Board or, if no such
     committee is appointed, the Board itself. Such committee or the Board, as
     the case may be, shall be responsible for the administration of the Plan,
     as provided in section 5 of the Plan.

          1.4. COMPANY means Neuromedica, Inc., a Delaware corporation.

          1.5. FAIR MARKET VALUE means (i) on any date prior to the Initial
     Public Offering Date, the value of a share of Stock on any such date as
     determined by the Committee, and (ii) on the Initial Public Offering Date
     or on any date thereafter, (A) the average of the closing bid and asked
     prices of a share of Common Stock on the over-the-counter market, as
     reported by the National Association of Securities Dealers, Inc. ("NASD")
     on such date, or (B) the closing price of a share of Common Stock on an
     exchange or the NASD's National Market System, as the case may be, on such
     date.

          1.6. GRANT DATE means the date as of which an Option is granted, as
     determined under Section 7.

          1.7. INCENTIVE OPTION means an Option which by its terms is to be
     treated as an "incentive stock option" within the meaning of Section 422 of
     the Code.

          1.8. INITIAL PUBLIC OFFERING DATE means the date of the closing of the
     Company's initial public offering of Common Stock.

          1.9. NON-STATUTORY OPTION means any Option that is not an Incentive
     Option.

          1.10. OPTION means an option to purchase shares of Stock granted under
     the Plan.

                                      -1-

<PAGE>

          1.11. OPTION AGREEMENT means an agreement between the Company and an
     Optionee, setting forth the terms and conditions of an Option.

          1.12. OPTION PRICE means the price paid by an Optionee for a share of
     Stock upon exercise of an Option.

          1.13. OPTIONEE means a person eligible to receive an Option, as
     provided in Section 6, to whom an Option shall have been granted under the
     Plan.

          1.14. PLAN means this Stock Option Plan of the Company, as amended
     from time to time.

          1.15. STOCK means Common Stock, par value $.001 per share, of the
     Company.

          1.16. STOCK RESTRICTION AGREEMENT means an agreement, if any, between
     the Company and an Optionee setting forth INTER ALIA conditions and
     restrictions upon the transfer of shares of Stock.

          1.17. TEN PERCENT OWNER means a person who owns, or is deemed within
     the meaning of Section 422(b)(6) of the Code to own, stock possessing more
     than 10% of the total combined voting power of all classes of stock of the
     Company (or its parent or subsidiary corporations). Whether a person is a
     Ten Percent Owner shall be determined with respect to each Option based on
     the facts existing immediately prior to the Grant Date of such Option.

          1.18. VESTING YEAR for any portion of any Incentive Option means the
     calendar year in which that portion of the Option first becomes
     exercisable.

          1.19. CHANGE IN CORPORATE CONTROL means (i) the time of approval by
     the shareholders of the Company of (A) any consolidation or merger of the
     Company in which the Company is not the continuing or surviving corporation
     or pursuant to which Stock would be converted into cash, securities or
     other property, other than a merger in which the holders of Stock
     immediately prior to the merger will have the same proportionate ownership
     of common stock of the surviving corporation immediately after the merger
     as before the merger, (B) any sale, lease, exchange or other transfer (in
     one transaction or a series of related transactions) of all or
     substantially all the assets of the Company, or (C) adoption of any plan or
     proposal for the liquidation or dissolution of the Company, or (ii) the
     date on which any "person" (as defined in Section 13(d) of the Exchange
     Act), other

                                      -2-

<PAGE>

     than the Company or a subsidiary or employee benefit plan or trust
     maintained by the Company or any of its subsidiaries shall become (together
     with its "affiliates" and "associates", as defined in Rule 12b-2 under the
     Exchange Act) the "beneficial owner" (as defined in Rule 13d-3 under the
     Exchange Act), directly or indirectly, of more than 25% of the Stock
     outstanding at the time, without the prior approval of the Board of
     Directors of the Company.

     2. PURPOSE. This Plan is intended to encourage ownership of Stock by
employees and consultants of the Company and its subsidiaries and to provide
additional incentives for them to promote the success of the Company's business.
The Plan is intended to be an incentive stock option plan within the meaning of
Section 422 of the Code but not all Options granted hereunder are required to be
Incentive Options.

     3. TERM OF THE PLAN. Options may be granted hereunder at any time in the
period commencing on the approval of the Plan by the Board and ending March 10,
2007.

     4. STOCK SUBJECT TO THE PLAN. Subject to the provisions of Section 17 of
the Plan, at no time shall the number of shares of Stock then outstanding which
are attributable to the exercise of Options granted under the Plan, plus the
number of shares then issuable upon exercise of outstanding Options granted
under the Plan, exceed 50,000 shares. Shares to be issued upon the exercise of
Options granted under the Plan may be either authorized but unissued shares or
shares held by the Company in its treasury. If any Option expires or terminates
for any reason without having been exercised in full, the shares not purchased
thereunder shall again be available for Options thereafter to be granted.

     5. ADMINISTRATION. The Plan shall be administered by the Committee. Subject
to the provisions of the Plan, the Committee shall have complete authority, in
its discretion, to make or to select the manner of making the following
determinations with respect to each Option to be granted by the Company: (a) the
employee or consultant to receive the Option; (b) whether the Option (if granted
to an employee) will be an Incentive Option or Non-statutory Option; (c) the
time of granting the Option; (d) the number of shares subject to the Option; (e)
the Option Price; (f) the Option period; (g) the Option exercise date or dates;
and (h) the effect of termination of employment, consulting or association with
the Company on the subsequent exercisability of the Option. In making such
determinations, the Committee may take into account the nature of the services
rendered by the respective employees and consultants, their present and
potential contributions to the success of the Company and its subsidiaries, and
such other factors as the Committee in its discretion shall deem relevant.
Subject to the provisions of the Plan, the Committee shall also have complete
authority to interpret the Plan, to prescribe, amend and rescind

                                      -3-
<PAGE>

rules and regulations relating to it, to determine the terms and provisions
of the respective Option Agreements (which need not be identical), and to make
all other determinations necessary or advisable for the administration of the
Plan. The Committee's determinations on the matters referred to in this Section
5 shall be conclusive.

     6. ELIGIBILITY. An Option shall be granted only to an employee or
consultant of one or more of the Company or any subsidiary thereof. A director
of one or more of the Company and any subsidiary who is not also an employee or
consultant of one or more of the Company or a subsidiary shall not be eligible
to receive an Option.

     7. TIME OF GRANTING OPTIONS. The granting of an Option shall take place at
the time specified in the Option Agreement. Only if expressly so provided in the
Option Agreement, shall the Grant Date be the date on which an Option Agreement
shall have been duly executed and delivered by the Company and the Optionee.

     8. OPTION PRICE. The Option Price under each Incentive Option shall be not
less than 100% of the Fair Market Value of Stock on the Grant Date, or not less
than 110% of the Fair Market Value of Stock on the Grant Date if the Optionee is
a Ten Percent Owner. The Option Price under each Non-statutory Option shall not
be so limited solely by reason of this Section 8.

     9. OPTION PERIOD. No Incentive Option may be exercised later than the tenth
anniversary of the Grant Date, but in any case not later than the fifth
anniversary of the Grant Date, if the Optionee is a Ten Percent Owner. The
Option period under each Non-statutory Option shall not be so limited solely by
reason of this Section 9. An Option may become exercisable in such installments,
cumulative or non-cumulative, as the Committee may determine. In the case of an
Option not otherwise immediately exercisable in full, the Committee may
accelerate the exercisability of such Option in whole or in part at any time,
provided the acceleration of the exercisability of any Incentive Option would
not cause the Option to fail to comply with the provisions of Section 422 of the
Code.

     10. LIMIT ON INCENTIVE OPTION CHARACTERIZATION. No Incentive Option shall
be considered an Incentive Option to the extent that pursuant to its terms it
would permit the Optionee to purchase for the first time in any Vesting Year
under that Incentive Option more than the number of shares of Stock calculated
by dividing the current limit by the Option Price. The current limit for any
Optionee for any Vesting Year shall be $100,000 minus the aggregate Fair Market
Value at the date of grant of the number of shares of Stock available for
purchase for the first time in the Vesting Year under each other Incentive
Option granted to the Optionee under the Plan after December 31, 1986 and each
other incentive stock option granted to the Optionee after December

                                      -4-
<PAGE>

31, 1986 under any other incentive stock option plan of the Company (and
any parent and subsidiary corporations).

     11. EXERCISE OF OPTION. An Option may be exercised by the Optionee giving
written notice, in the manner provided in Section 22, specifying the number of
shares with respect to which the Option is then being exercised. Such notice
shall be accompanied by payment in the form of cash, or certified or bank check
payable to the order of the Company, in an amount equal to the option price of
the shares to be purchased. In the event that notice of exercise is given prior
to the Initial Public Offering Date, such notice shall be accompanied by an
executed counterpart of a Stock Restriction Agreement, if any, if the exercising
Optionee is not already a party to a Stock Restriction Agreement. Payment may at
the election of the Optionee be made in whole or in part by the surrender of a
whole number of shares of previously issued Stock of the Company. Previously
issued shares of Stock shall be accepted in an amount equal to the then Fair
Market Value of the surrendered shares. In addition, the Optionee may surrender
a portion of his Option with respect to vested Shares as payment for other
Shares which have also vested, and in such case the portion of the Option
surrendered shall be considered a payment equal to the Fair Market Value of the
vested Option Shares which could be purchased with the surrendered portion of
the Option less the aggregate exercise price for such Option Shares. The Company
may, in the sole discretion of the Committee, make an advance to the Optionee of
his salary in an amount sufficient to cover any applicable withholding taxes
resulting from Option exercise. Receipt by the Company of notice, payment and,
if applicable, executed counterpart shall constitute the exercise of the Option.
Within 30 days thereafter but subject to the remaining provisions of the Plan,
the Company shall deliver or cause to be delivered to the Optionee or his agent
a certificate or certificates for the number of shares then being purchased.
Such shares shall be fully paid and nonassessable.

     12. RESTRICTIONS ON ISSUE OF SHARES.

     (a) Notwithstanding any other provision of the Plan, if, at any time, in
the reasonable opinion of the Company the issuance of shares of Stock covered by
the exercise of any Option may constitute a violation of law, then the Company
may delay such issuance and the delivery of a certificate for such shares until
(i) approval shall have been obtained from such governmental agencies, other
than the Securities and Exchange Commission, as may be required under any
applicable law, rule, or regulation; and (ii) in the case where such issuance
would constitute a violation of a law administered by or a regulation of the
Securities and Exchange Commission, one of the following conditions shall have
been satisfied:

                                      -5-
<PAGE>

          (1) the shares with respect to which such Option has been exercised
     are at the time of the issue of such shares effectively registered under
     the Securities Act of 1933, as amended (the "Securities Act"); or

          (2) a no-action letter in form and substance reasonably satisfactory
     to the Company and its counsel with respect to the issuance of such shares
     shall have been obtained by the Company from the Securities and Exchange
     Commission.

The Company shall make all reasonable efforts to bring about the occurrence of
said events.

     (b) Each certificate representing shares issued upon the exercise of an
Option will bear restrictive legends which may refer to this Plan and to
applicable restrictions under a Stock Restriction Agreement.

     13. PURCHASE FOR INVESTMENT; SUBSEQUENT REGISTRATION.

     (a) Unless the shares to be issued upon exercise of an Option granted under
the Plan have been effectively registered under the Securities Act, the Company
shall be under no obligation to issue any shares covered by any Option unless
the person who exercises such Option, in whole or in part, shall give a written
representation to the Company which is satisfactory in form and substance to its
counsel and upon which the Company may reasonably rely, that he or she is
acquiring the shares issued pursuant to such exercise of the Option as an
investment and not with a view to, or for sale in connection with, the
distribution of any such shares.

     (b) Each share of Stock issued pursuant to the exercise of an Option
granted pursuant to this Plan may bear a reference to the investment
representation made in accordance with this Section 13 and to the fact that no
registration statement has been filed with the Securities and Exchange
Commission in respect to said Stock.

     (c) If the Company shall deem it necessary or desirable to register under
the Securities Act or other applicable statutes any shares with respect to which
an Option shall have been granted, or to qualify any such shares for exemption
from the Securities Act or other applicable statutes, then the Company shall
take such action at its own expense. The Company may require from each Option
holder, or each holder of shares of Stock acquired pursuant to the Plan, such
information in writing for use in any registration statement, prospectus,
preliminary prospectus or offering circular as is reasonably necessary for such
purpose and may require reasonable indemnity to the Company and its officers and
directors from such holder against all losses, claims, damage and liabilities
arising from such use of the information so furnished and

                                      -6-
<PAGE>

caused by any untrue statement of any material fact therein or caused by
the omission to state a material fact required to be stated therein or necessary
to make the statements therein not misleading in the light of the circumstances
under which they were made.

     14. WITHHOLDING; NOTICE OF DISPOSITION OF STOCK PRIOR TO EXPIRATION OF
SPECIFIED HOLDING PERIOD.

     (a) Whenever shares are to be issued in satisfaction of an Option granted
hereunder, the Company shall have the right to require the Optionee to remit to
the Company an amount sufficient to satisfy federal, state, local or other
withholding tax requirements if and to the extent required by law (whether so
required to secure for the Company an otherwise available tax deduction or
otherwise) prior to the delivery of any certificate or certificates for such
shares.

     (b) The Company may require as a condition to the issuance of shares
covered by any Incentive Option that the party exercising such Option give a
written representation to the Company which is satisfactory in form and
substance to its counsel and upon which the Company may reasonably rely, that he
or she will report to the Company any disposition of such shares prior to the
expiration of the holding periods specified by Section 422(a)(1) of the Code. If
and to the extent that the realization of income in such a disposition imposes
upon the Company federal, state, local or other withholding tax requirements, or
any such withholding is required to secure for the Company an otherwise
available tax deduction, the Company shall have the right to require that the
recipient remit to the Company an amount sufficient to satisfy those
requirements; and the Company may require as a condition to the issuance of
shares covered by an Incentive Option that the party exercising such option give
a satisfactory written representation promising to make such a remittance.

     15. TERMINATION OF ASSOCIATION WITH THE COMPANY. If the Optionee's
employment or association with the Company is terminated, whether voluntarily or
otherwise, the Option, to the extent the Option is exercisable on the date of
termination, may be exercised by the Optionee, but only within 90 days after he
or she ceases to be an employee of or consultant to the Company, unless
terminated earlier by its terms. Notwithstanding the foregoing, in the event
that the applicable Option Agreement with respect to an Option shall contain
specific provisions governing the effect that any such termination shall have on
the exercisability of such Option, such provisions in the Option Agreement
shall, to the extent that they are inconsistent with the provisions of this
Section 15, control and deem to supersede the provisions of this Section 15. For
purposes of this Section 15, military or sick leave shall not be deemed a
termination of employment, PROVIDED that it does not exceed the longer of 120
days or the period during which the absent Optionee's reemployment rights, if
any, are guaranteed by statute or by contract.

                                      -7-
<PAGE>

     16. TRANSFERABILITY OF OPTIONS. Options shall not be transferable,
otherwise than by will or the laws of descent and distribution, and may be
exercised during the life of the Optionee only by the Optionee.

     17. ADJUSTMENT OF NUMBER AND KIND OF OPTION SHARES.

     (a) In the event of any stock dividend payable in Stock or any split-up or
contraction in the number of shares of Stock after the date of an Option
Agreement and prior to the exercise in full of the Option, the number of shares
subject to such Option Agreement and the price to be paid for each share subject
to the Option shall be proportionately adjusted. In the event of any
reclassification, exchange, conversion or change of outstanding shares of Stock,
or in case of any consolidation or merger of the Company with or into another
company, or in case of any sale or conveyance to another company or entity of
the property of the Company as a whole or substantially as a whole, shares of
stock or other securities equivalent in kind and value to those shares an
Optionee would have received if he or she had held the full number of shares of
Stock subject to the Option immediately prior to such reclassification,
exchange, conversion, change, consolidation, merger, sale or conveyance and had
continued to hold those shares (together with all other shares, stock and
securities thereafter issued in respect thereof) to the time of the exercise of
the Option shall thereupon be subject to the Option. Upon dissolution or
liquidation of the Company, the Option shall terminate, but the Optionee (if at
the time in the employ of or retained as a consultant to the Company or any of
its subsidiaries) shall have the right, immediately prior to such dissolution or
liquidation, to exercise the Option to the extent exercisable on the date of
such dissolution or liquidation. No fraction of a share shall be purchasable or
deliverable upon exercise, but in the event any adjustment hereunder of the
number of shares covered by the Option shall cause such number to include a
fraction of a share, such number of shares shall be adjusted to the nearest
smaller whole number of shares. In the event of changes in the outstanding Stock
by reason of any stock dividend, split-up, contraction, reclassification, or
change of outstanding shares of Stock of the nature contemplated by this Section
17, the number of shares of Stock available for the purpose of the Plan as
stated in Section 4 shall be correspondingly adjusted.

     (b) Upon the close of business on the Initial Public Offering Date, each
Option then outstanding shall cease to be exercisable for shares of Stock and
shall become exercisable for shares of Common Stock of the Company. The number
of shares of Common Stock that shall become subject to each such Option upon the
close of business on the Initial Public Offering Date shall be equal to the
number of shares of Stock subject to each such Option on the date immediately
preceding such Initial Public Offering Date. From and after the Initial Public
Offering Date, each such Option shall be exercisable only in accordance with the
terms set forth in, and to the extent provided in, this Plan or any applicable
Option Agreement (including, without limitation,

                                      -8-
<PAGE>

any vesting schedule set forth therein), all to the same extent as if each such
Option were still exercisable for shares of Stock. Without limiting the
generality of the preceding sentence, nothing in this Section 17(b) shall be
construed as accelerating the exercisability of any Option.

     18. CHANGE IN CORPORATE CONTROL. Upon a change in Corporate Control, each
outstanding Option shall immediately become fully exercisable.

     19. RESERVATION OF STOCK. The Company shall at all times during the term of
the Options reserve or otherwise keep available such number of shares of Stock
as will be sufficient to satisfy the requirements of the Plan and shall pay all
fees and expenses necessarily incurred by the Company in connection therewith.

     20. LIMITATION OF RIGHTS IN STOCK; NO SPECIAL EMPLOYMENT OR OTHER RIGHTS.
The Optionee shall not be deemed for any purpose to be a stockholder of the
Company with respect to any of the shares of Stock covered by an Option, except
to the extent that the Option shall have been exercised with respect thereto
and, in addition, a certificate shall have been issued therefor and delivered to
the Optionee or his agent. Any Stock issued pursuant to the Option shall be
subject to all restrictions upon the transfer thereof which may be now or
hereafter imposed by the Certificate of Incorporation, the By-laws of the
Company, and a Stock Restriction Agreement. Nothing contained in the Plan or in
any Option shall confer upon any Optionee any right with respect to the
continuation of his or her employment with, or retention as a consultant by, the
Company (or any subsidiary), or interfere in any way with the right of the
Company (or any subsidiary), subject to the terms of any separate employment or
consulting agreement or provision of law or corporate articles or by-laws to the
contrary, at any time to terminate such employment or consulting agreement or to
increase or decrease the compensation of the Optionee from the rate in existence
at the time of the grant of an Option.

     21. TERMINATION AND AMENDMENT OF THE PLAN. The Board may at any time
terminate the Plan or make such modifications of the Plan as it shall deem
advisable. No termination or amendment of the Plan may, without the consent of
the Optionee to whom any Option shall theretofore have been granted, adversely
affect the rights of such Optionee under such Option.

     22. NOTICES AND OTHER COMMUNICATIONS. All notices and other communications
required or permitted under the Plan shall be effective if in writing and if
delivered or sent by certified or registered mail, return receipt requested (a)
if to the Optionee, at his or her residence address last filed with the Company,
and (b) if to the Company, at 1100 E. Hector Street, Suite 450, Conshohocken, PA
19428, with a copy to its Chief Financial Officer at such address, or to

                                      -9-
<PAGE>

such other persons or addresses as the Optionee or the Company may specify by
a written notice to the other from time to time.

                                      -10-

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