Document:

10Q Q1 2001 EXH10.154

                                                          Exhibit 10.154

Exhibit B

PROMISSORY NOTE

$300,000South San Francisco, California

January 2, 2000

For Value Received, the undersigned hereby
unconditionally, promises to pay to the order of Axys Pharmaceuticals,
Inc., a Delaware corporation (the "Company"), at the offices of
the Company, 180 Kimball Way, South San Francisco, California, or at such other
place as the holder hereof may designate in writing, in lawful money of the
United States of America and in immediately available funds, the principal sum
of Three Hundred Thousand Dollars ($300,000) and interest accrued from the date
hereof on the unpaid principal at the rate of 5.61% per annum, or the maximum
rate permissible by law (which under the laws of the State of California shall
be deemed to be the laws relating to permissible rates of interest on commercial
loans), whichever is less, compounded annually, as follows:
Principal Repayment.  The outstanding principal amount
hereunder shall be due and payable in full on January 2, 2004 and

Interest Payments. Interest shall be compounded
annually (calculated on the basis of a 365-day year for the actual number of
days elapsed) and shall be payable in arrears on the Principal Repayment
Date.

In addition, and notwithstanding the foregoing, provided that
the undersigned continues to render services to the Company through each such
date, the Company will forgive one thirty-sixth (1/36th) of the
principal amount of the Note and any accrued interest thereon on the first day
of each calendar month following the date hereof.  In the event the undersigned
ceases providing services to the Company, whether as an employee, consultant, or
member of the Company's Board of Directors, for any reason or no reason, the
principal and all accrued interest due under this Note shall become due and
payable in full no later than thirty (30) days after the date of such final
cessation of service (but in no event later than the Principal Repayment Date);
provided, however, that in the event the undersigned is terminated without Cause
or due to death or disability or that the undersigned terminates his employment
for Good Reason, the Company will concurrently therewith forgive all remaining
principal and interest due under the Note.  Capitalized terms used herein
without definition shall be defined to have the same meaning as such terms have
in that certain Employment Agreement dated as of January 2, 2001 between the
Company and the undersigned.

This Note may be prepaid at any time without penalty. All
money paid toward the satisfaction of this Note shall be applied first to the
payment of interest as required hereunder and then to the retirement of the
principal.  

The full amount of this Note is secured by a pledge of any
shares of Common Stock of the Company that the undersigned may purchase from
time to time through the exercise of Company stock options, and is subject to
all of the terms and provisions of that form of Pledge Agreement between the
undersigned and the Company, attached as Exhibit A.

The undersigned hereby represents and agrees that the amount
due under this Note are not consumer debt, and are not incurred primarily for
personal, family or household purposes, but are for business and commercial
purposes only.

The undersigned hereby waives presentment, protest and notice
of protest, demand for payment, notice of dishonor and all other notices or
demands in connection with the delivery, acceptance, performance, default or
endorsement of this Note.

The holder hereof shall be entitled to recover, and the
undersigned agrees to pay when incurred all costs and expenses of collection of
this Note, including without limitation, reasonable attorneys' fees.

This Note shall be governed by, and construed, enforced and
interpreted in accordance with, the laws of the State of California, excluding
conflict of laws principles that would cause the application of laws of any
other jurisdiction.  

Signed ____________________________

Paul HastingsExhibit 10.1

                              EMPLOYMENT AGREEMENT

     In consideration of the promises hereinafter contained,  CryoLife,  Inc., a
Florida  corporation ("we", "our" and "us") and Sidney B. Ashmore ("you") hereby
agrees as of this 9th day of September, 1996 to the following:

     1. Employment. We hereby employ you and you hereby accept employment on the
terms and conditions set forth below. Your duties and compensation are set forth
on the Exhibit attached hereto.

     2. Extent of  Services.  During your  employment,  you agree to devote your
full and  exclusive  time and  attention  to your  employment  duties and not to
engage in any other  business  activity  which  conflicts  or competes  with our
business or which reduces your  effectiveness  in  performing  your duties under
this Agreement unless you have first obtained our prior written consent.

     3.  Benefits and Absences.  You are entitled to all benefits  offered by us
for  which  you  meet  the  eligibility  requirements.  You are  subject  to the
obligations  concerning  absences  due to  disability,  sick  leave,  and  other
absences,  described in the current  benefit  summary  schedule,  and as revised
hereafter.

     4. Term and Termination. Your employment shall commence on the date of this
Agreement.  Both you and we shall  have the right  upon  giving 30 days  written
notice to the other to terminate with or without cause the employment under this
Agreement.  However,  if one party to this Agreement  terminates the employment,
the other  party may at his  option  effect  the  separation  immediately.  This
Agreement  shall  automatically  terminate  in the  event  of your  death.  Such
automatic  termination  shall  discharge  both  parties  hereto from any and all
further liability or responsibility to the other under this Agreement.

     5. Right to Change  Duties.  We reserve  the right to change the nature and
scope  of your  duties.  In the  event  of any  transfer  to  another  corporate
facility,  we shall  defray the  reasonable  cost of  transporting  you and your
family with household furnishings to your new location.

     6. Secrecy and  Noncompetition.  Your  employment and continued  employment
with us is  conditioned  upon your signing our standard  Secrecy and  Noncompete
Agreement  whose terms and  agreements  you agree to be bound by. You agree that
under no condition will any breach or infraction of this Agreement be assertable
as a defense to any action or  responsibility  incurred by you under the Secrecy
and Noncompete Agreement.

     7. Your  Warranties.  You present and warrant  that you will not utilize or
disclose any trade secrets or  proprietary  information of others to us and that
the only  secrecy  and/or  noncompetition  agreements  you have with  others are
identified on the attached exhibit.

                                       11
<PAGE>

     8. Moving Expense.  CryoLife,  Inc. has paid for certain moving expenses to
facilitate your relocation. We reserve the right to withhold the total amount of
these expenses from any monies due to you if you terminate your  employment from
CryoLife,  Inc.  within 12 months  from your  first day of work at the  Company.
These expenses  include all charges  associated  with moving and storage of your
personal belongings.

     9.  Miscellaneous.  This Agreement may not be changed or terminated  orally
and no change, termination or attempted waiver of the provisions hereof shall be
binding  unless in writing  and signed by the parties  against  whom the same is
sought to be enforced;  provided,  however,  that the  compensation  paid to you
hereunder  may be increased at any time by us without in any way  affecting  any
other term or  condition of this  Agreement  which in all other  respects  shall
remain in force and effect.  This Agreement shall be governed by the laws of the
State of Georgia.

     IN WITNESS  WHEREOF,  this  Agreement has been duly executed on the day and
year first above written.

                                   CRYOLIFE, INC.

                                   By: ________________________________

                                   Its:  ______________________________

                                   EMPLOYEE

                                   ____________________________________

                                       2
<PAGE>

                         Exhibit to Employment Agreement

Duties:                    Director, Marketing
                           ------------------------------------

                           ------------------------------------

                           ------------------------------------

                           ------------------------------------

                           ------------------------------------

Compensation:              $7,750.00/Monthly Plus Company
                           ------------------------------------

                           Fringe Benefits
                           ------------------------------------

Secrecy and
Noncompetition
Agreements
With Others*:              $7,750.00/Monthly Plus Company
                           ------------------------------------

                           Fringe Benefits
                           ------------------------------------

                           ------------------------------------

                           ------------------------------------

                           (*Copies of these must be promptly provided
                           to CryLife)

                                       3
1359140v1Exhibit 10.2

                                                                  EXECUTION COPY

                       ASSIGNMENT AND ASSUMPTION AGREEMENT

     This Assignment and Assumption  Agreement (this  "Agreement") is made as of
March  30,  2001  by  and  among  Horizon  Medical  Products,  Inc.,  a  Georgia
corporation ("Horizon"), Vascutech Acquisition LLC, a Delaware limited liability
company  ("Vascutech"),  and Ideas for  Medicine,  Inc.,  a Florida  corporation
("IFM").

                                   BACKGROUND

     WHEREAS, Horizon is party to that certain Subordinated Promissory Note made
in favor of IFM and dated October 9, 2000, in the original  principal  amount of
$5,945,216,  which  was  subsequently  adjusted  upward  by an  amount  equal to
$104,838 (the "Subordinated Note");

     WHEREAS,  pursuant to the terms of that certain  Asset  Purchase  Agreement
between  Horizon and Vascutech,  of even date herewith,  Vascutech is purchasing
certain  assets  comprising  the Ideas for  Medicine  business  unit of  Horizon
("Assets") and a portion of the consideration to be paid by Vascutech to Horizon
for such  Assets will be the  assumption  by  Vascutech  of the  liabilities  of
Horizon to IFM under the Subordinated Note (the "Assumption"); and

     WHEREAS, IFM desires to consent to the Assumption as set forth herein.

     NOW,  THEREFORE,  for  consideration,  the receipt and adequacy of which is
hereby acknowledged, the undersigned hereby agree as follows:

A.   Assignment and Assumption

          1. (a) Horizon,  IFM and Vascutech  hereby  acknowledge and agree that
     the  current  outstanding  principal  amount  of the  Subordinated  Note is
     $5,348,870.27;  and  (b)  Horizon  hereby  assigns,  and  Vascutech  hereby
     assumes,  each and every obligation of Horizon under the Subordinated Note,
     and  Vascutech   expressly   agrees  (i)  to  pay  all  amounts  under  the
     Subordinated  Note as they become due and  payable  from and after the date
     hereof and (ii) to be unconditionally  bound by the terms and conditions of
     said Subordinated Note, as such Subordinated Note may be amended, extended,
     renewed, modified, amended, restated,  substituted or replaced from time to
     time,  as though  Vascutech had  originally  signed the  Subordinated  Note
     instead of Horizon.

          2. IFM hereby consents to the foregoing assignment and assumption.

          3. Each of Horizon and  Vascutech  agree,  upon the request of IFM, to
     execute  such  other  documents  as  IFM  reasonably  deems  necessary  and
     appropriate  from time to time to reflect the  assignment and assumption as
     set forth above.

B.   Representations  and Warranties of Vascutech:  Vascutech hereby  represents
     and warrants to IFM as follows:

          1. Vascutech is validly organized and existing and in good standing as
     a  limited  liability  company  under  the laws of the  state of  Delaware.
     Vascutech has the power to own its property and to carry on its business as
     currently conducted.

          2.  Vascutech  has the  limited  liability  company  power,  right and
     authority  to  execute  and  deliver  this  Agreement  and the  Transaction
     Documents  (as  defined  below) and to take all  actions  and  perform  all
     obligations contemplated to be performed by it under this Agreement and the
     Transaction Documents.

<PAGE>

          3. The execution and delivery of this Agreement, that certain Security
     Agreement of even date herewith by Vascutech in favor of IFM (the "Security
     Agreement"),  that certain Certificate of Consent and Estoppel (exclusively
     with respect to Section 6 thereof) of even date  herewith  among  CryoLife,
     IFM and,  with respect to Section 6 thereof only,  Vascutech  (the "Consent
     and Estoppel"), that certain Consent to Assignment of Sublease of even date
     herewith by and among IFM, Horizon, Vascutech and Secret Promise, Ltd. (the
     "Sublease  Consent")  and that certain  Assignment of Sublease of even date
     herewith by and among IFM, Horizon and Vascutech (the "Sublease Assignment"
     and, collectively, with this Agreement, the Security Agreement, the Consent
     and Estoppel and the Sublease Consent,  the "Transaction  Documents"),  the
     taking of all action required in connection herewith and therewith, and the
     performance  by Vascutech of all of the  obligations  by it to be performed
     hereunder  and  thereunder,  have been  duly  authorized  by all  necessary
     limited   liability   company  action,   including,   without   limitation,
     authorization by Vascutech's  sole manager and sole member.  This Agreement
     and the rest of the  Transaction  Documents  have  been duly  executed  and
     delivered by Vascutech and constitute the valid and binding  obligations of
     Vascutech  enforceable  against  Vascutech in accordance  with their terms,
     except as limited by bankruptcy,  insolvency,  reorganization,  and similar
     laws  affecting  the  enforcement  of  creditor's   rights  or  contractual
     obligations generally.

C.   Representation  and  Warranty of Horizon:  Horizon  hereby  represents  and
     warrants to IFM that the Assets being sold by Horizon to Vascutech pursuant
     to the Asset Purchase  Agreement of even date herewith  between Horizon and
     Vascutech  (the  "Vascutech  Purchase  Agreement")  constitute  all  of the
     Collateral  existing  as of the date  hereof  under and as  defined in that
     certain Security  Agreement dated as of October 9, 2000 by Horizon in favor
     of IFM, except for those items of Collateral included within the definition
     of Excluded Assets set forth on Exhibit A attached hereto.

D.   Parent  Guaranty:  In  consideration  of IFM extending  credit to Vascutech
     pursuant to the terms of the Subordinated Note, the undersigned, Vascutech,
     Inc., a corporation  organized and existing  under the laws of Delaware and
     the 100% parent of  Vascutech  (the  "Guarantor"),  hereby  unconditionally
     guarantees to IFM that  Vascutech  will duly and punctually pay or perform,
     at the place specified therefor, (i) all obligations under the Subordinated
     Note and the Transaction  Documents (the  "Obligations"),  and (ii) without
     limitation of the foregoing,  all fees, costs and expenses  incurred by IFM
     in attempting to collect or enforce any of the foregoing  (collectively the
     "Guaranteed Obligations").  This guaranty is an absolute, unconditional and
     continuing  guaranty of the full and punctual  payment and  performance  by
     Vascutech of the  Guaranteed  Obligations  and not of their  collectibility
     only and is in no way  conditioned  upon  any  requirement  that IFM  first
     attempt to collect any of the  Guaranteed  Obligations  from  Vascutech  or
     resort to any  security or other means of  obtaining  payment of any of the
     Guaranteed  Obligations.  Upon the  occurrence of an Event of Default under
     (and as defined in) the  Subordinated  Note by  Vascutech,  the  Guaranteed
     Obligations  shall, at the option of IFM, become  forthwith due and payable
     to IFM without  demand or notice of any nature,  all of which are expressly
     waived  by the  Guarantor.  Payments  by  the  Guarantor  hereunder  may be
     required by IFM on any number of occasions.  The Guarantor  further agrees,
     as the  principal  obligor  and  not  as a  guarantor  only,  to pay to IFM
     forthwith  upon  demand,  in  funds  immediately   available  to  IFM,  all
     reasonable  costs and expenses  (including  court costs and legal expenses)
     incurred  or  expended  by IFM in  connection  with this  guaranty  and the
     enforcement thereof.

E.   Miscellaneous:  This  Agreement  shall be  governed  by the  provisions  of
     Delaware law without regard to conflicts of laws principles thereof.

                         [SIGNATURES BEGIN ON NEXT PAGE]

                                       2
<PAGE>

     IN WITNESS  WHEREOF,  the parties hereto have executed this Agreement under
seal as of the date first set forth above in multiple  counterpart  copies, each
of which shall be deemed to be an original for all purposes.

HORIZON MEDICAL PRODUCTS, INC.                  VASCUTECH ACQUISITION LLC

By:   /s/ William E. Peterson, Jr.              By:   /s/ David B. Roberts
    ----------------------------------              -------------------------
      Name:  William E. Peterson, Jr.                 Name:  David B. Roberts
      Title:  President                               Title:  CFO
      hereunto duly authorized                        hereunto duly authorized

CONSENTED TO:

IDEAS FOR MEDICINE, INC.

By:   /s/ D.A. Lee
    ----------------------------------
      Name:  D. Ashley Lee
      Title:  VP - Finance and CFO
      hereunto duly authorized

JOINED FOR PURPOSES OF PARAGRAPH D. ONLY:

VASCUTECH, INC.

By:   /s/ David B. Roberts
    ----------------------------------
      Name:  David B. Roberts
      Title:  CFO
      hereunto duly authorized

                                       3
<PAGE>

                                LIST OF EXHIBITS
                                ----------------

EXHIBIT A   - Excluded Assets
EXHIBIT A-1 - Ideas for Medicine Product Line

1358823v1

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