Document:

Option and License Agreement

 Exhibit 10.242 
 Portions of this exhibit marked [*] are omitted and are requested to be treated confidentially. 
 OPTION AND LICENSE AGREEMENT 
 THIS OPTION AND LICENSE AGREEMENT (the
“Agreement”) is effective as of the 15th day of December, 2006 (the “Effective Date”) by and
among PHARMACO INVESTMENTS, INC., a Delaware corporation having a place of business at 3151 South Seventeenth Street, Wilmington, North Carolina 28412 (referred to hereinafter as “PII”), a wholly owned subsidiary of Pharmaceutical Product
Development, Inc., a North Carolina corporation having its principal place of business at 3151 South 17th Street, Wilmington, NC 28412 (“PPD”), and RANBAXY LABORATORIES LTD., a corporation incorporated, organized and operating under the
laws of India and having a place of business at Plot 90, Sector 32 Gurgaon 122001 (Haryana), India (hereinafter “RBX”). PII and RBX are sometimes referred to herein individually as a “Party” and collectively as the
“Parties.” PPD is a Party to this Agreement for the sole and limited purpose of agreeing to be bound by Section 12.19 of this Agreement. 
 WITNESSETH THAT: 
 WHEREAS, RBX has performed research and development with respect to a [*] identified as
[*]; 
 WHEREAS, PII wishes to enter into an agreement to obtain an exclusive option to acquire an exclusive license to RBX Intellectual Property (as
defined below) and to develop and market therapeutic products incorporating the Compound made in accordance therewith; and 
 WHEREAS, RBX is willing to
grant such exclusive option to acquire an exclusive license to PII under the terms and conditions set forth in this Agreement. 
 NOW, THEREFORE, PII and RBX
hereby agree as follows: 
 ARTICLE I – DEFINITIONS 
 1.01. “AB Rated Product” means a product which has been approved by a Regulatory Agency having an approved application that contains adequate scientific evidence establishing, through in
vitro and/or in vivo studies, the bioequivalence of such product to a Licensed Product developed under this Agreement and which product contains the same active pharmaceutical ingredient as such Licensed Product. 
 1.02. “Affiliate” of a Party hereto shall mean any entity that controls, is controlled by or is under common control with such Party. For purposes of
this definition, a Party shall be deemed to control another entity if it owns or controls, directly or indirectly, at least fifty percent (50%) of the voting equity of another entity (or other comparable ownership interest for an entity other
than a corporation) or if it has management control of the other entity. 
  

 [*] Confidential treatment requested; certain information omitted and filed separately with the SEC. 

 1.03. “API” means active pharmaceutical ingredient. 
 1.04. “Clinical Studies” means Phase I Clinical Studies, Phase II Clinical Studies, Phase III Clinical Studies, and/or Post-Registration Studies.

 1.05. “Combination Product” means any product in any dosage form that contains, in addition to a Licensed Product, one or more other
active ingredients having significant prophylactic or therapeutic activity. 
 1.06. “Complete” or “Completion”, when used to
describe a clinical study, shall mean the date when all data and results of such study have been collected and the final study report has been completed. 
 1.07. “Compound” means: (a) [*]; (b) any pharmaceutically acceptable salt of the foregoing; (c) any active metabolite of the foregoing; (d) any isomer of the foregoing; (e) any enantiomer of
the foregoing; and (f) any prodrug of the foregoing. 
 1.08. “Compound Know-How” means any Know-How, including Manufacturing Know-How,
that is Controlled by RBX and is necessary for the development of the Compound or a Licensed Product. 
 1.09. “Confidential Information”
shall have the meaning set forth in Section 9.01. 
 1.10. “Controlled” means, with respect to any compound, material, information or
intellectual property right, that the Party owns or has a license to such compound, material, information or intellectual property right and has the ability to grant to the other Party access, a license or a sublicense (as applicable under this
Agreement) to such compound, material, information or intellectual property right as provided for herein without violating the terms of any agreement or other arrangements with any Third Party existing at the time such Party would be first required
hereunder to grant the other Party such access, license or sublicense. 
 1.11. “CTM Product” means the Compound together with any
formulation ingredients in a finished pharmaceutical dosage form suitable for administration and dosing to humans in Clinical Studies, but not in suitable form for commercial sale (for example, without limitation, not in packaged form such as
blister packs or other containers and not including external packaging and package inserts). 
 1.12. “Develop” or
“Development” means conducting in vitro and/or in vivo pre-clinical investigations and Clinical Studies of the Compound (including the manufacture of CTM Product and Drug Substance) and the Licensed
Products (including any placebo), and preparing, submitting and prosecuting all applications to obtain Regulatory Approval of the Licensed Products for sale in the Field in the Territory. 
  

	[*]	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  

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 1.13. “Development Plan” means the initial plan to Develop the first Licensed Product for the
Indication, attached hereto as of the Effective Date as Schedule 1.13, as such Development Plan may be modified or updated in accordance with Section 4.01. 
 1.14. “Diligent Efforts” means the carrying out by PII, its Affiliate, sublicensee or Third Party Partner of obligations or tasks in a sustained and continuous manner consistent with the efforts a
reasonable Third Party, engaged in the development and commercialization of pharmaceutical products for human use, ordinarily devotes (including meeting the timelines for development and commercialization) to a research, development or marketing
project for a pharmaceutical product or products of similar market potential, profit potential or strategic value to that of the Compound based on conditions then prevailing. Diligent Efforts includes without limitation, using commercially
reasonable efforts to sublicense the licenses granted under this Agreement to a Third Party for the continued development, manufacture and commercialization of the Compound and the Licensed Products. Notwithstanding the foregoing, the requirement to
exercise “Diligent Efforts” does not require that PII conduct Clinical Studies or other Development studies relating to the Compound of the size and scope previously conducted by Third Party pharmaceutical companies to obtain Regulatory
Approval of statin products for the Indication, except to the extent PII is otherwise required to do so by the FDA. Without limiting the Parties’ rights under Section 12.18, the Parties understand and agree that delays resulting
from the occurrence of Force Majeure events or Interfering Events shall not be grounds for RBX to claim a failure to use Diligent Efforts or that a material breach of this Agreement has occurred; provided, however, that (i) PII uses Diligent
Efforts to avoid the occurrence of such delays, and (ii) uses Diligent Efforts to reduce the impact of such delays following their occurrence. 
 1.15. “Drug Substance” means the Compound suitable for administration and dosing to a human. 
 1.16. “EMEA” means
the European Medicine Agency. 
 1.17. “Enforceable Claim” means a claim included in an issued and unexpired patent that has not been:
(i) abandoned or disclaimed; or (ii) declared invalid or unenforceable by a decision of a court or other governmental agency of competent jurisdiction, which decision is unappealable or unappealed within the time allowed for appeal.

 1.18. “FDA” means the United States Food and Drug Administration, or any successor thereto. 
 1.19. “FD&C Act” means the United States Food, Drug and Cosmetic Act, as amended and the rules and regulations of the FDA promulgated thereunder.

 1.20. “Field” means all human uses. 
 1.21. “First Commercial Sale” means the first transaction following Regulatory Approval of a Licensed Product in which PII, its Affiliate, sublicensee or Third Party Partner transfers physical possession and title to such
Licensed Product to a Third Party in exchange for value and after which transfer the seller has no right or power to determine the Third Party’s resale price. Transfer for research, clinical development or testing only purposes shall not
constitute the First Commercial Sale. 
  

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 1.22. “Force Majeure” shall mean conditions or events that are beyond the control of a Party or
any Third Party vendors, sublicensee or Third Party Partner of PII, including, without limitation, fire, flood, earthquake, storm, war, acts of God, accident, voluntary or involuntary compliance with any regulation, law or order of any government,
civil commotion, labor strike or lock-out, epidemic, failure or default of public utilities or common carriers, explosion and/or any other cause or externally induced casualty beyond such Party’s control; provided, however, that
except as specifically provided above, Force Majeure shall not include delays caused by the conduct of Third Party vendors, sublicensees or a Third Party Partner of PII in the Development, Regulatory Approval or commercialization of the Licensed
Products, including, without limitation, manufacturers of the Licensed Products. 
  

	1.23.	“GAAP” means generally accepted accounting principles in the United States, consistently applied. 

 1.24. “GMP” means the FDA’s then-current good manufacturing practices applicable to the manufacture of pharmaceutical products for human use in the
United States, the FDA’s guidance documents, and all successor regulations and guidance documents. 
 1.25. “IND” means Investigational
New Drug Application submitted to the FDA in conformance with applicable laws and regulations and the foreign equivalent of such application in non-U.S. countries of the Territory. 
 1.26. “Indication” means dyslipidemia, including, without limitation, hypercholesterolemia, hyperlipidemia or hypertriglyceridemia. 
 1.27. “Interfering Event” means (i) any decision ruling, directive, instructions, position, guidance or other action, whether in writing or otherwise of a Regulatory Agency, IRB or ethics
committee, any change in a Regulatory Agency, IRB or ethics committee approval processes or regulatory requirements (including Clinical Study requirements) from those in effect on the Effective Date, or any inaction on the part of a Regulatory
Agency, IRB or ethics committee, in each case that materially affects the requirements for, or the timeline of, the Development and Regulatory Approval of the Licensed Product(s) in the U.S. or other countries in which Regulatory Approval is being,
or is required to be, sought, (ii) a Licensed Product Manufacturing Failure, or (iii) a determination by PPD, in the exercise of its reasonable discretion, that data or other information obtained during the course of, or as a result of,
any Clinical Study for the Compound or Licensed Product(s) will have a material adverse affect on the safety or efficacy of the Licensed Product(s) or require that additional Development activities be conducted (exceeding that provided in the then
current Development Plan) for the Development and Regulatory Approval of the Licensed Product(s). 
  

	1.28.	“Joint Invention” shall have the meaning in Section 7.01. 

  

	1.29.	“Joint Patents” shall have the meaning in Section 7.03. 

  

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 1.30. “Joint Patent Rights” shall have the meaning in Section 7.01. 
 1.31. “Know-How” means any unpatented or unpatentable inventions, information, data, drawings, plans, specifications and designs relating to the
Compound, a CTM Product or a Licensed Product including, in particular, any marketing information, preclinical, clinical, toxicology, analytical, regulatory, ADME information and/or data. As used herein, “ADME” refers to absorption,
distribution, metabolism and excretion information and/or data of the Compound or Licensed Product. 
 1.32. “Licensed Product” means any
product: (i) which contains the Compound, or any isomer, homolog, analog or prodrug of the Compound, or (ii) which, if made, used or sold in the absence of the license granted by RBX to PII under this Agreement, would infringe an
Enforceable Claim of a RBX Patent or Joint Patent. 
 1.33. “Licensed Product Manufacturing Failure” means any failure, disruption, delay or
any other problem encountered by PII, its contract manufacturer or Third Party Partner relating to the manufacture, formulation or production of API, CTM Product or Licensed Product under the Development Plan. 
 1.34. “MAA” means Marketing Authorization Application submitted to the EMEA. 
 1.35. “Major Regulatory Filings” has the meaning provided in Section 4.03. 
 1.36.
“Manufacturing Know-How” means any Know-How that is Controlled by RBX and relates to the manufacture of the Compound or a Licensed Product including processes and analytical methods therefore. 
 1.37. “NDA” means a New Drug Application, as defined in the FD&C Act and applicable FDA rules and regulations, and the foreign equivalent of such
application in non-U.S. countries of the Territory. 
 1.38. “Net Sales” means the total gross sales (number of units shipped times the
invoice price per unit) of all Licensed Products by PII, its Affiliates, sublicensees (including sublicensees of any sublicensee), Affiliates of sublicensees and/or a Third Party Partner in the Territory to Third Parties, less the following
deductions to the extent actually paid or allowed: (i) quantity discounts, cash discounts or chargebacks actually granted, allowed or incurred in the ordinary course of business in connection with the sale of Licensed Product; (ii) sales
and excise taxes, customs and any other taxes, all to the extent added to the sale price and paid by the selling party and not refundable in accordance with applicable law (but not including taxes assessed against the income derived from such sale);
(iii) freight, insurance and other transportation charges to the extent added to the sale price and set forth separately as such in the total amount invoiced; (iv) reserves for amounts to be repaid or credited by reason of rejections,
defects, recalls or returns or because of retroactive price reductions, chargebacks, rebates or commissions; (v) rebates or allowances actually granted or allowed to group purchasing organizations, managed health care organizations and to
governments, including their agencies, or to trade customers, in each case that are not Affiliates, sublicensees or a Third Party Partner of PII; and (vi) allowances or credits 

  

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to customers, not in excess of the selling price of Licensed Product, on account of governmental requirements, rejection, outdating recalls or return of the
Licensed Product, made in accordance with GAAP and PII’s accounting policies. Sales between PII and its Affiliates, sublicensees and a Third Party Partner of PII shall not be treated as Net Sales hereunder. The calculation of Net Sales shall be
made in accordance with GAAP and PPD’s accounting policies. 
 1.39. “Option” shall have the meaning provided in
Section 2.01 hereof. 
 1.40. “Option Period” shall have the meaning provided in Section 2.02 hereof. 
 1.41. “Option Termination Date” shall mean April 1, 2007. 
 1.42. “Partnering Agreement” means an executed and in-force written agreement between PII and a Third Party, wherein such Third Party is granted the right to develop (if applicable) and commercialize,
alone or in collaboration with PII, a human therapeutic product that comprises the Compound. For clarity, an agreement in which PII engages a Third Party to perform, on behalf of PII, certain obligations of PII under the Development Plan is not a
Partnering Agreement. 
 1.43. “Patent” means (i) unexpired letters patents (including inventor’s certificates) of which not all
claims have been held invalid or unenforceable by a court of competent jurisdiction from which no appeal can be taken or has been taken within the required time period, including without limitation any substitution, extension, registration,
confirmation, reissue, re-examination, renewal or any like filing thereof and (ii) pending applications for letters patent, including without limitation any continuation, division or continuation-in-part thereof and any provisional
applications. 
 1.44. “Phase I Clinical Study” means that portion of the Development program that generally provides for the first
introduction into humans of the Compound with the primary purpose of determining safety, metabolism and pharmacokinetic properties and clinical pharmacology of the CTM Product in healthy patients, and generally consistent with 21 CFR
§312.21(a), or its foreign equivalent in non-U.S. countries of the Territory. A Phase I Clinical Study can comprise a Phase Ia clinical study and a Phase Ib clinical study. A Phase Ia clinical study is a study performed in healthy humans. A
Phase Ib clinical study is a study performed in human patients. 
 1.45. “Phase II Clinical Study” means a clinical trial of the Compound on
patients, including possibly pharmacokinetics and dose ranging studies, the principal purposes of which are to make a preliminary determination that the Compound is safe for its intended use and to obtain sufficient information about the
Compound’s efficacy to permit the design of further clinical trials, and generally consistent with 21 CFR §312.21(b), or its foreign equivalent in non-U.S. countries of the Territory. A Phase II Clinical Study can comprise a Phase IIa
clinical study and a Phase IIb clinical study. 
 1.46. “Phase III Clinical Study” means a clinical trial involving administration of the
Compound to sufficient numbers of human patients with the goal of establishing that the Compound is safe and efficacious for its intended use, to define warnings, precautions and 

  

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adverse reactions that are associated with the drug or label expansion of the Compound, and to be considered as a pivotal study for submission of an NDA; and
generally consistent with 21 CFR §312.21(b), or its foreign equivalent in non-U.S. countries of the Territory. A Phase III Clinical Study can comprise a Phase IIIa clinical study and a Phase IIIIb clinical study. A Phase IIIb clinical study is
performed to further define findings found in a Phase IIIa clinical study. 
 1.47. “Post-Registration Studies” means Clinical Studies which
are conducted in a particular country after the attainment of Regulatory Approval from the appropriate Regulatory Agency in that country, which studies are conducted for a variety of purposes including, but not limited to, post-marketing
surveillance and/or other studies intended to confirm or enhance the commercial profile of the particular Licensed Product. 
 1.48. “PII
Information” means information, results and data of any type whatsoever, in any tangible or intangible form whatsoever, including without limitation, databases, inventions, practices, methods, techniques, specifications, formulations,
formulae, knowledge, know-how, skill, experience, test data including pharmacological, biological, chemical, biochemical, toxicological and clinical test data, analytical and quality control data, stability data, studies and procedures, and patent
and other legal information or descriptions produced by PII in the course of developing a Licensed Product, including PII Compound Information. 
 1.49.
“PII Patents” shall have the meaning set forth in Section 7.03(b). 
 1.50. “PII Compound Information” means the data and
results generated from the pre-clinical and clinical investigation and Development, and Clinical Studies and testing of the Compound and/or the Licensed Products during the term of this Agreement in the course of the Development Plan or related work
on the Compound or Licensed Products by PII or on behalf of PII, its Affiliates, sublicensees and/or a Third Party Partner. 
 1.51. “Regulatory
Agency” means the FDA or an equivalent non-U.S. regulatory agency. 
 1.52. “RBX Intellectual Property” means (i) the Compound
Know-How, including, without limitation, Manufacturing Know-How, (ii) RBX Patents, and (iii) RBX’s portion of Joint Patent Rights. 
 1.53.
“RBX Patents” means all Patents that are owned or Controlled by RBX or its Affiliates during the term of this Agreement and that claim the Compounds or any Licensed Products or the Development, manufacture, intermediates made during
the manufacture thereof, purification, use or formulation thereof. RBX Patents include without limitation patents that claim RBX Intellectual Property. RBX Patents as of the Effective Date are listed in Schedule 1.53. 
 1.54. “Regulatory Approval” means the product license or marketing approval necessary as a prerequisite for marketing a Licensed Product in a particular
country in the Territory, including, where applicable, pricing and reimbursement approval. 
 1.55. “Regulatory Documentation” means all
regulatory filings and supporting documents created, submitted to a Regulatory Agency (including any supra-national agency such as in the 

  

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European Union) relating to a Licensed Product, and all data contained therein, including, without limitation, the contents of any IND(s), NDA(s), Drug
Master File (“DMF”), correspondence to and from the Regulatory Agency or governmental authority outside of the United States, minutes from meetings (whether in person or by audioconference or videoconference) with regulatory authorities,
registrations and licenses, regulatory drug lists, advertising and promotion documents shared with regulatory authorities, adverse event files, complaint files and manufacturing records. 
 1.56. “Territory” shall mean all countries of the world. 
 1.57. “Third Party” means any
person or entity other than PII or RBX, or an Affiliate of PII or RBX. 
 1.58. “Third Party Partner” means a Third Party that has entered
into a Partnering Agreement. 
 ARTICLE II – OPTION TO LICENSE 
 2.01 License Option. In consideration for the payment by PII to RBX of the sum of [*] pursuant to the terms of a certain Letter Agreement between
the Parties dated August 2, 2006, the covenants and agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which is acknowledged by RBX, subject to and upon the terms and conditions of this
Agreement, RBX hereby grants to PII an exclusive option to acquire an exclusive, royalty bearing license and sublicense rights to the RBX Intellectual Property in the Field in the Territory, all as set forth in Article I and Articles III through XII
of this Agreement (the “Option”). 
 2.02 Term of the Option. The term of the Option shall commence on the Effective Date and shall
expires at 5:00 pm Eastern Standard Time on the Option Termination Date (the “Option Period”). 
 2.03 Exercise of Option. PII may
exercise the Option during the Option Period by delivering written notice to RBX of PII’s exercise of the Option on or before the expiration of the Option Period. The date on which such notice is given in accordance with Section 12.08
shall be the “Option Exercise Date” for purposes of this Agreement. If PII does not exercise the Option on or before the expiration of the Option Period, each of the Option and this Agreement shall terminate and be of no further force and
effect. 
 2.04 Option Covenants. Between the Effective Date and the earlier to occur of (i) the Option Exercise Date, and (ii) the
Option Termination Date, RBX covenants that (a) it will take all reasonably necessary action to protect and maintain all right, title and interest in RBX Intellectual Property existing as of the Effective Date, and (b) it will not grant,
sell, assign, transfer, covey, option, license, sublicense, pledge or otherwise dispose of all or any part of the RBX Intellectual Property, or any rights thereto, to a Third Party, or enter into any agreement, arrangement, understanding or
discussions with a Third Party with respect thereto. 
  

	[*]	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  

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 2.05 License Terms. Upon the timely exercise by PII of the Option in accordance with Section 2.03,
effective immediately on the Option Exercise Date and without any further action or consent by RBX or PII, the provisions set forth in Article I and Articles III – XII of this Agreement shall constitute the terms and conditions of the license
and sublicense rights granted by RBX to PII with respect to the RBX Intellectual Property in the Territory and in the Field related to Compound and Licensed Products. 
 ARTICLE III – LICENSES AND EXCLUSIVITY 
 3.01 License to RBX Intellectual Property.
Effective as of the Option Exercise Date, subject to and upon the terms and conditions set forth herein, RBX hereby grants PII an exclusive, royalty bearing license (with the right to sublicense as provided in Section 3.02) to RBX Intellectual
Property to Develop, make, have made, use, offer for sale, sell and import the Compound and the Licensed Products in the Territory and the Field. 
 3.02
Right to Sublicense. With respect to the licenses granted to PII in Section 3.01 above, such licenses shall include the right of PII to sublicense all or any part of such licenses to a Third Party, provided however, that
(i) such sublicense is consistent with the terms of this Agreement, and (ii) PII shall provide prior written notice to RBX of the proposed sublicense. For clarification, PII has no obligation to obtain RBX’s consent to sublicense.
Notwithstanding any sublicense by PII of its rights under Section 3.01 or elsewhere in this Agreement, PII shall remain the primary obligor for the completion of the Development of the Compound and Licensed Products, the commercialization of
the Licensed Products and all other obligations, including payment obligations, under this Agreement and shall be responsible for any breach or failure to comply by any sublicensee or Third Party Partner of any of the obligations of PII provided in
this Agreement. 
 3.03 Exclusivity. Except as set forth in Section 3.04, during the term of this Agreement, RBX and its Affiliates will
not, directly or indirectly through or with an Affiliate, Third Party or otherwise, (i) make, use, sell or import the Compound or (ii) conduct, sponsor, fund, underwrite, initiate or otherwise participate in any development or
commercialization activities (or grant any rights to Third Parties to do so) with respect to the Compound in the Field. 
 3.04 RBX Co-Marketing
Rights. 
 (a) RBX reserves for itself and its Affiliates the non-exclusive right to co-market the Licensed Product(s) (i) at any
time in India, and (ii) as an AB Rated Product in any country in the Territory following the sale of an AB Rated Product by a Third Party in such country. Ranbaxy may contract with Third Parties for the distribution of the Licensed Products
pursuant to the exercise of the co-marketing rights provided herein. As used herein, RBX’s right to “co-market” means the right for RBX (either itself or through its Affiliates or a Third Party) to manufacture, sell,
distribute, promote and market Licensed Products under trademarks, tradenames, service marks, designs or names or other trade dress which are different from, and which are not confusingly similar to, any trademarks, tradenames, service marks,
designs or names (including without limitation domain names), graphics or trade dress (including without limitation product packaging and tablet characteristics) used by PII, any PII Affiliate, any 

  

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sublicensee or Third Party Partner of PII in connection with such Licensed Product. RBX agrees not to reproduce or use any text or copyrighted work covering
the Licensed Product without PII’s prior written consent. 
 (b) If RBX decides to exercise its co-marketing rights provided in
Section 3.04(a) [*]. At the time RBX decides to exercise its co-marketing rights, RBX may send to PII a written request to discuss the possibility of RBX [*]. Upon RBX’s reasonable determination that a Third Party is expected
to launch within six (6) months an AB Rated Product in a country of the Territory, RBX may at such time request [*] launch of its co-marketed product in such country upon exercise of its co-marketing right as set forth in subsection
(a) of this Section 3.04. 
 ARTICLE IV –CONDUCT OF PROJECT; DEVELOPMENT; MARKETING 
 4.01 General Principle. During the term of this Agreement, as between PII and RBX, PII shall be solely responsible for the Development of the Compound and
the Licensed Product(s), including, without limitation, the conduct of the Development Plan for the Compound and the Licensed Product(s), and such other development activities in accordance with the Development Plan, and for the marketing,
manufacture and commercialization of the Compound and the Licensed Product(s) in the Territory consistent with its obligations under this Agreement. PII will use Diligent Efforts to Develop and commercialize the Compound and at least one
(1) Licensed Product for the Indication. PII shall have responsibility for, and shall exercise Diligent Efforts in, obtaining necessary Regulatory Approvals, and PII or its Affiliates, sublicensees or Third Party Partner, shall hold legal title
of any [*] for the Licensed Product(s) and shall have responsibility for all the Development, manufacture and marketing activities pursuant to and in support of such applications. RBX acknowledges that the Development Plan is an initial plan
and may change as a result of data obtained during the execution of the Development Plan, changes to Regulatory Agency guidelines and requirements and prevailing conditions in the marketplace for the Licensed Product. PII shall have the right to
modify the Development Plan in its sole and absolute discretion, but shall use Diligent Efforts to advance the Development and commercialization of the Compound and the Licensed Product. 
 4.02 Development Reports. 
 (a) Quarterly Development Reports. PII shall furnish
to the alliance manager as may be designated from time to time by RBX (the “Alliance Manager”) a quarterly written report detailing the progress of the Development, including successes, difficulties, milestone achievements and a comparison
of the status of the Development as compared to the Development timeline contained in the Development Plan, including (i) a description of the status of the preparation, filing and receipt of Regulatory Approvals relating for the Licensed
Product(s) in the Territory, (ii) any updates or modifications to the Development Plan, and (iii) the estimated date of the First Commercial Sale of the Licensed Products in each country of the Territory in which PII has submitted agency
applications for Regulatory Approval of the Licensed Product(s). Such reports shall constitute Confidential Information under Article IX and RBX will limit disclosure to its employees on a strict need-to-know basis. The first quarterly report shall
be provided to RBX on April 1, 2007 and on the first day of each July, October, January and April thereafter. 
  

 [*] Confidential treatment requested; certain information omitted and filed separately with the SEC. 
  

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 (b) Record Keeping. PII shall maintain written records of all research and development activities under the
Development Plan, such records shall be complete and accurate and shall fully and properly reflect all work done and results achieved in the execution of the Development Plan in sufficient detail and in good scientific manner appropriate for patent
and regulatory drug development and approval purposes. RBX shall have the right to review such records annually to the extent necessary for RBX to determine that PII is fulfilling its obligations under the Agreement. The Parties acknowledge and
agree that all information in such records shall be subject to the confidentiality obligations of Article IX hereof. 
 4.03 Development; Regulatory
Activities and Approvals.  
 (a) PII shall use Diligent Efforts and be responsible for the conduct of the Development of the Compound
and the Licensed Product(s) within the Territory in order to obtain and maintain Regulatory Approval of a [*] (“Major Regulatory Filings”) for a Licensed Product for the Indication as promptly as practicable. In executing the
Development Plan, PII shall be solely responsible for all costs and expenses relating to the Development Plan and obtaining Regulatory Approval for the Licensed Product(s). Without limiting the generality of the foregoing, PII shall be responsible
for the preparation, filing and prosecution of all agency applications for obtaining Regulatory Approvals in the Territory which are required to commercially sell or use the Licensed Product(s) in the Territory and for all subsequent related
submissions. All Regulatory Documentation and Regulatory Approvals in the Territory shall be owned and filed in the name of PII. PII shall use Diligent Efforts in preparing the Major Regulatory Filings for Regulatory Approval of the Licensed
Product(s) and in causing such agency applications to progress through the Regulatory Approval process. PII shall use Diligent Efforts for the preparation and submission of all governmental and agency applications for Regulatory Approval for a
Licensed Product for the Indication in countries of the Territory other than [*] (which are addressed separately above) in which PII determines to submit agency applications, and the receipt of such Regulatory Approvals, including, without
limitation, pricing and reimbursement approval, where applicable. 
 (b) If PII receives a written communication from a Regulatory Agency,
either directly or through a sublicensee or a Third Party Partner of PII, relating to the Compound or the Licensed Product(s) which relate to the Development, marketing, safety or efficacy of the Compound or the Licensed Products, and which would
materially affect the time for receipt of Regulatory Approval of such Licensed Product(s) or the ability of PII to Develop or market such Licensed Product(s), PII shall promptly provide RBX’s Alliance Manager (as provided in
Section 4.02(a)) with a summary of such information. Such summary shall be subject to the confidentiality obligations of Article IX hereof. 
 4.04
Launch and Marketing. 
 (a) PII, at is sole cost and expense, shall use Diligent Efforts to complete the First Commercial
Sale of a Licensed Product in [*] as soon as practicable after Regulatory Approval has been obtained for such Licensed Product, and thereafter shall use Diligent Efforts to manufacture, promote, distribute, market, advertise and sell the
Licensed Product (or cause the manufacture, promotion, distribution, marketing, advertisement and sale of the Licensed 
  

	[*]	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  

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Product) to the extent reasonable in light of the market and potential market for the Licensed Product and in a manner consistent with which a Third Party
engaged in the commercialization of pharmaceutical products for human use ordinarily devotes to marketing for a pharmaceutical product having similar market potential, profit potential or strategic value to that of the Licensed Product in a
particular country of the Territory. For the sake of clarity, RBX acknowledges and agrees that, based on market conditions, including pricing conditions and environment, then existing in [*], PII may delay or elect not to manufacture,
promote, distribute, market, advertise or sell the Licensed Product in any such Country. Without limiting the foregoing, not later than 30 days following the end of each calendar year following the First Commercial Sale of any Licensed Product, PII
shall provide to RBX a written report summarizing PII’s (or its Third Party Partner’s) marketing efforts relating to the Licensed Product during such annual period. 
 (b) Restrictive Covenant. Neither PII nor any of its Affiliates shall develop, license, acquire, file for Regulatory Approval, market, promote,
sell or distribute [*] other than the Compound and the Licensed Product(s) hereunder, or [*] other than the Compound and the Licensed Product(s) hereunder in combination with another active ingredient in any country of the Territory
during the term of this Agreement, except that PII and any of its Affiliates may provide services to Third Parties in connection with the preclinical and clinical development or post-marketing studies of one or more [*], provided that
(i) such services are limited to those that are usual and customary for clinical research organizations in general, and PII and its Affiliates in particular; and (ii) PII and its Affiliates shall not retain (1) any right, title,
interest or license in any such [*]; or (2) any right to receive (directly or indirectly) any consideration in connection with the subsequent development, regulatory filings, regulatory approval, promotion or sales of such [*]
(other than normal and customary fees and expenses charged by PII and its Affiliates for any such services). 
 4.05 Transfer of Know-How.

 (a) To facilitate PII’s accomplishment of the responsibilities set forth in this Article IV, RBX shall supply PII with copies
of all documents pertinent to the Development of the Compound which are in the possession of RBX or its Affiliates as of the Effective Date including but not limited to those documents listed in Schedule 4.05. RBX shall use reasonable
commercial efforts to provide such documents to PII within forty-five (45) days of the Option Exercise Date. RBX will provide PII with all relevant information available and known to RBX concerning the safety, handling, use, disposal and
environmental effects of Compound or as may be useful to PII to conduct the Development Plan, including but not limited to any communications with regulatory agencies. The Parties acknowledge and agree that all such Compound-related information,
including, without limitation, the Manufacturing Know-How, shall be subject to the confidentiality obligations of Article IX hereof. 
 (b) Within ten (10) days of the Option Exercise Date, RBX shall make available for shipping, [*] totaling approximately [*] and [*] that are in RBX’s possession as of the Effective Date (“RBX [*]”). PII shall pay
to RBX the amount of [*] dollars ($[*]), within thirty (30) days of an invoice for the same. PII acknowledges and agrees that RBX is providing the RBX [*] on an “as is” basis, free of any representation or warranty, including, without
limitation, the warranties of merchantability or fitness for any particular purpose. 
  

	[*]	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  

 12 

 4.06 Manufacturing. PII shall be solely responsible for (i) the manufacture of CTM Product and Drug
Substance as may be required to obtain Regulatory Approval of the Licensed Product(s) in the Territory and (ii) the manufacture of commercial requirements of the Licensed Product(s) for marketing and sale in the Territory.  

 

	4.07	[*]. 

 ARTICLE V – FEES AND ROYALTIES

 5.01 License Fee. PII shall, simultaneous with the provision of written notice to RBX exercising the Option on the Option Exercise
Date, pay to RBX a one-time non-refundable, non-creditable license fee in the amount of two hundred fifty thousand dollars ($250,000) (the “License Fee”). 
 5.02 Clinical Milestone Payments. In addition to paying the License Fee, and without limiting Section 5.02(d) below, PII shall pay RBX the following non-refundable, non-creditable additional amounts
upon the first occurrence of the applicable event (individually a “Milestone Payment” and collectively the “Milestone Payments”): 
 (a) Completion of [*]. PII will notify RBX in writing upon the Completion of the [*] in any country of the Territory to be performed in the Development Plan involving CTM Product within fourteen
(14) days of such Completion. Within thirty (30) days of the Completion thereof, PII will pay RBX a one-time milestone payment of [*]. For clarity, if [*] are contemplated in the Development Plan, then Completion of the
[*] shall occur upon the Completion of the [*]. In the event multiple arms of such [*] are performed using different comparitors and/or patient populations, the Milestone Payment under this Section 5.02(a) shall be
triggered upon the Completion of the last arm of such [*] (expressly excluding any requirement to complete any [*]) relating to such [*]. 
 (b) Completion of [*]. PII will notify RBX in writing upon Completion of the [*] in any country in the Territory to be performed in the Development Plan involving a CTM Product within fourteen
(14) days of such Completion. Within thirty (30) days of the Completion thereof, PII will pay RBX a one-time milestone payment of [*]. For clarity, if [*] are contemplated in the Development Plan, then Completion of the
[*] shall occur upon the Completion of the [*]. In the event multiple arms of such [*] are performed using different comparitors and/or patient populations, the Milestone Payment under this Section 5.02(b) shall be
triggered upon the Completion of [*] relating to such [*] (expressly excluding any requirement to complete any [*]). 
 (c) Completion of [*]. PII will notify RBX in writing upon Completion of the [*] in any country in the Territory to be performed in the Development Plan involving a CTM Product within fourteen (14) days of such
Completion. Within thirty (30) days of the Completion thereof, PII will pay RBX a one-time milestone payment of [*]. For clarity, if [*] are 
  

 [*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

  

 13 

 
contemplated in the Development Plan, then Completion of the [*] shall occur upon the Completion of the [*]. In the event multiple arms of a
[*] are performed using different comparitors and/or patient populations, the Milestone Payment under this Section 5.02(c) shall be triggered upon the Completion of [*] relating to such [*] (expressly excluding any
requirement to complete any [*]). 
 (d) Completion of Payments. Subject to this Section 5.02(d), PII shall only be
obligated to pay the Milestone Payments under Section 5.02(a), 5.02(b) and 5.02(c) once. For clarity, except as expressly provided below, once PII makes the Milestone Payment under either Section 5.02(a), 5.02(b) or 5.02(c) relating to the
Development Plan, PII shall have no further obligation to make any further Milestone Payments under Section 5.02(a), 5.02(b) or 5.02(c) to RBX for any future occurrence of such milestone event relating to another program for the Development of
the Compound for the Indication. In the event that PII pursues the Development of the Compound to treat an indication that is [*] (other than [*]), PII shall pay RBX the milestone payments set forth in Sections 5.02(a)-(c) upon
the occurrence of the milestone event with respect to the Development of such Compound for such [*] indication. Notwithstanding the foregoing or anything to the contrary contained in this Agreement, in the event PII pursues the Development of
the Compound (whether in a single or combination product) for the treatment of [*], the Parties shall negotiate in good faith the separate and additional milestone payments to be made by PII to RBX pursuant to such Development program;
provided, however, that such separate and additional milestone payments must exceed those provided in this Section 5.02 in the aggregate. 
 5.03
Sales Milestones. PII shall pay to RBX sales milestone payments in accordance with the schedule set forth below with regard to the Licensed Products, based on total worldwide Net Sales of the Licensed Products for the first consecutive
twelve month period during which such sales milestone event is achieved, such payment to be made within thirty (30) days after achievement of such milestone event. Each of the milestone payments listed in this Section 5.03 shall be payable
only once under this Agreement regardless of the number of Licensed Products that individually achieve the sales milestone event in a given 12-month period or the number of times the Licensed Products achieve such sales milestone event in a given
12-month period. 
  

			
	 Sales Milestone Event
	  	 Sales Milestone Payment

	 First time that aggregate worldwide Net Sales of all Licensed Products in the aggregate in a twelve consecutive month period exceed
[*]
	  	[*]
	 First time that aggregate worldwide Net Sales of all Licensed Products in the aggregate in a twelve consecutive month period exceed
[*]
	  	[*]
	 First time that aggregate worldwide Net Sales of all Licensed Products in the aggregate in a twelve consecutive month period exceed
[*]
	  	[*]
	 First time that aggregate worldwide Net Sales of all Licensed Products in the aggregate in a twelve consecutive month period exceed
[*]
	  	[*]

  

 [*] Confidential treatment requested; certain information omitted and filed separately with the SEC. 
  

 14 

 5.04 Royalties. Subject to the terms and conditions of this Agreement, PII shall pay to RBX a royalty in
the amount of [*] percent ([*]%) of Net Sales of each Licensed Product in the Territory commencing with the First Commercial Sale of the first Licensed Product. 
 5.05 Royalty Period. PII’s obligation to pay royalties to RBX under Section 5.04 shall apply on a Licensed Product-by-Licensed Product basis and shall begin, on a country by country basis, upon
the date of the First Commercial Sale in such country of such Licensed Product and shall end upon termination of sale of the Licensed Product in such country. 
 5.06 Payments to Third Parties. In the event PPD determines that it is necessary or desirable to seek a license or immunity from suit from any Third Party in order for PPD to exercise its rights hereunder to Develop,
manufacture, commercialize, use or exploit the Compound or a Licensed Product in a particular country of the Territory, PPD shall obtain any such license or immunity from suit. Any upfront payment, milestone, royalty or other payment paid or payable
by PPD to a Third Party in consideration for immunity from or license to such Third Party’s intellectual property rights with respect to the Compound or a Licensed Product shall be solely for PPD’s account and RBX shall have no liability
(including, without limitation, any indemnity obligation) for any such amounts. 
 5.07 Method of Calculation. The calculation of the amount of
royalties due under the provisions of Section 5.04 shall be subject to and computed in accordance with the following provisions: 
 (a) Frequency. Royalties shall be calculated and paid on a calendar quarter basis. PII shall provide RBX with a statement of royalties owed to RBX within thirty (30) days after the end of each calendar quarter and the
quarterly royalty payment shall be made at the time of such statement. Each of the quarterly statement of royalties and the annual statement provided in the following sentence shall show in reasonably specific detail, on a country-by-country basis
(i) the total number of units of each of the Licensed Products sold, (ii) the Net Sales on a Licensed Product-by-Licensed Product basis (including the detailed calculation of the deductions from gross sales of each of the Licensed Products
in arriving at Net Sales); (iii) the calculation of the royalties payable pursuant to Section 5.04 in United States dollars which had been accrued hereunder based upon Net Sales of each Licensed Product, including a detailed calculation
showing the application of the applicable royalty rates under Section 5.04 to the aggregate Net Sales for all Licensed Products; (iv) the withholding taxes, if any, required by law to be deducted with respect to such royalties and the
amounts paid to the appropriate governmental authority with respect to such royalties; (v) the date of the first Commercial Sale of each Licensed Product in each country in the Territory during the reporting period; and (vi) the exchange
rates used in determining the amount of United States dollars. In addition, at the end of each calendar year, aggregate royalties for such calendar year shall be calculated on aggregate Net Sales for all Licensed Products for such calendar year to
determine additional royalty payments owed to RBX by PII. Within sixty (60) days after the end of each calendar year, PII shall provide RBX with a statement of such additional aggregate royalty payments owed to RBX and a written report showing
the method by which the royalty payments for such calendar year were calculated, including a breakdown of gross sales and Net Sales for each Licensed Product sold, including any exchange rates used. If there are no sales of Licensed Product in a
country in a given year, 
  

	[*]	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  

 15 

 
then no statement for such country shall be included in such yearly report. PII shall submit any additional aggregate royalty payments to RBX together with
such statement and written report. With respect to sales of any Licensed Products invoiced in United States dollars, the Net Sales and royalties and other payments payable hereunder shall be expressed in United States Dollars. With respect to sales
of any Licensed Products invoiced in a currency other than United States Dollars, the Net Sales and royalties and other payments payable hereunder with respect to such Licensed Products shall be expressed in the domestic currency of the party making
the sale together with the United States dollar equivalent of the royalty payment payable, and such exchange rate shall be calculated pursuant to Section 6.03. 
 (b) Combination Products. PII shall pay RBX royalties on Net Sales of any Combination Product. For the purpose of calculating royalties on Net Sales of Combination Products hereunder, Net Sales of a
Combination Product shall be determined on a country by country basis by multiplying the actual Net Sales of the Combination Product by the fraction A/(A+B), where A is the average sale price of a Licensed Product in a given country when sold
separately in finished form and B is the average sale price of the other product(s) comprising the active ingredients other than the Compound sold separately in finished form in that given country. With respect to Net Sales of Combination Products
outside of the United States, where available in a given country, the most recent reference price(s) or government-regulated price(s) for the other product(s) in the given country will be used as the average sale price. In the event that such
average sale price cannot be determined for either the Licensed Product or other product(s) in the Combination Product, Net Sales for purposes of determining royalty payments hereunder shall be calculated by multiplying the Net Sales of the
Combination Product by the fraction C/(C+D), where C is PII’s, or its Affiliates’, sublicensees’ or Third Party Partner’s cost of goods of the Licensed Product and D is PII’s, or its Affiliates’, sublicensees’ or
Third Party Partner’s cost of goods of the other product(s), in each case determined in accordance with GAAP. 
 (c) Royalty and
Patents. Regardless of the number of patents that cover a Licensed Product, only one royalty shall be payable upon sale of a Licensed Product. 
 (d) Other Consideration. In the case of a sale or other disposal of Licensed Product for value other than in an arm’s-length
transaction exclusively for money, such as barter or counter-trade, the amount of such sale shall be calculated using the fair market value of such Licensed Product (if higher than the stated sales price) in the country of disposition. 

ARTICLE VI – Royalty Records, Verification and Payment 
 6.01 Books and Records. PII shall keep and shall require any Affiliates, sublicensees and Third Party Partner selling any Licensed Product to keep proper records and books of account, in accordance with
GAAP, showing the Net Sales of each Licensed Product upon which the royalty payments and Sales Milestone Payments of PII are based, and all other information necessary for the accurate determination of royalty payments to be made hereunder.

 6.02 Audit. On reasonable written notice RBX, at its own expense, shall have the right, no more than once a calendar year, to have an
independent certified public accountant inspect and 

  

 16 

 
audit the books and records of PII, its Affiliates, any sublicensees and Third Party Partner, including any Net Sales reports received from its Affiliates,
its sublicensees and its Third Party Partner, during usual business hours for the sole purpose of, and only to the extent necessary for, determining the correctness of royalty payments due under this Agreement. Such examination with respect to any
fiscal period shall not take place later than three years following the expiration of such period, after which royalty payments made for such fiscal periods shall be final and binding. The expense of any such audit shall be borne by RBX; provided,
however, that, if the audit with respect to a particular calendar year discloses an error in excess of five percent (5%) in favor of the PII, then PII shall pay, in addition to the amount of any underpayment, the cost of the audit. PII shall
include substantially the same audit rights in any sublicense it grants in order to ensure correctness of payments due hereunder. 
 6.03 Foreign
Payments. All payments due hereunder shall be paid in U.S. dollars, including, without limitation, royalties on Net Sales outside of the U.S. Dollar amounts shall be calculated in the foreign currency for the country in which sales are
recorded and will be translated into U.S. dollars based on the average of the average daily exchange rates for such calendar quarter as published by the Wall Street Journal for the quarter for which such payments are due. Payments in U.S. dollars
shall be paid by wire transfer to RBX. 
 ARTICLE VII – INTELLECTUAL PROPERTY 
 7.01 Ownership of Patents.  
 Inventorship of
inventions conceived or reduced to practice in the course of the activities under the Development Plan shall be determined by reference to United States laws pertaining to inventorship. If inventions are conceived or reduced to practice in the
course of activities under the Development Plan by an individual obliged to assign patent rights to RBX and an individual obliged to assign patent rights to PII, it shall be jointly owned (“Joint Invention”), and if one or more claims
included in any issued Patent or pending Patent application which is filed in a patent office in the Territory claim such Joint Invention, such claims shall be jointly owned (“Joint Patent Rights”). Subject to Section 3.01, during the
term of this Agreement, the Parties shall not use or grant any rights under, or otherwise commercialize any Joint Patent Rights or any Joint Invention, and the Parties shall not disclose any Joint Invention to any third Party (except to the extent
each Party would be permitted to disclose Confidential Information pursuant to Article IX) without obtaining the prior written consent of the other Party or without mutually agreeing in writing upon terms and condition, including a royalty or other
compensation to the other Party. After the expiration or termination of this Agreement, the Parties may use or grant any rights under, or otherwise commercialize, any Joint Patent Rights or any Joint Invention in the Territory, and the Parties may
disclose any Joint Invention to any Third Party, all without obtaining the prior written consent of the other Party and without any accounting obligations. If an invention is solely conceived or reduced to practice in the course of activities under
the Project by an employee, consultant or agent of a Party, it shall be solely owned by such Party, and any Patent filed claiming such solely owned invention shall also be solely owned by such Party. 
  

 17 

 7.02 Ownership of PII Information. PII shall own the entire right, title and interest in and to any and all
PII Information. 
 7.03 Patent Prosecution. 
 (a) PII shall have the right and obligation to control the preparation, filing, prosecution, maintenance and defense of RBX Patents. PII shall control the preparation, filing, prosecution, maintenance and
defense of patent applications directed to Joint Patent Rights. (“Joint Patents”). In discharging its obligations under this Section 7.03(a) PII shall exercise diligent efforts, in a sustained and continuous manner, consistent with
the efforts it ordinarily devotes to the preparation, filing, prosecution, maintenance and defense of its own patents and intellectual property. RBX shall provide PII any reasonable assistance required to perfect the RBX Patent Rights and RBX shall
provide PII reasonable assistance required to perfect the Joint Patent Rights. PII shall provide RBX with drafts of all proposed patent filings (including, without limitation, patent applications, amendments and responses to official actions) at
least thirty (30) days before filing and shall take into account any comments provided by RBX to PII, to the extent reasonable, within thirty (30) days (or such shorter period as shall be required to meet a filing deadline, but in no event
less than fifteen (15) days) after RBX’s receipt of the applicable draft. If PII decides not to file or maintain any RBX Patent on a country-by-country basis or patent family basis, PII shall give RBX reasonable notice of same and after
receipt of such notice, RBX may, at its expense, file or maintain such applications or patents at its own expense. PII shall provide RBX with drafts of all proposed patent filings relating to the Joint Patents (including, without limitation, patent
applications, amendments and responses to official actions) at least thirty (30) days before filing and shall take into account any comments provided by RBX to PII, to the extent reasonable, within thirty (30) days (or such shorter period
as shall be required to meet a filing deadline, but in no event less than fifteen (15) days) after RBX’s receipt of the applicable draft. If PII decides not to file or maintain any Joint Patent, on a country-by-country basis or patent
family basis, PII shall give RBX reasonable notice of same and after receipt of such notice, RBX may at its expense, file or maintain such applications or patents, and PII shall assign such patents and patent applications to RBX that RBX elects to
file or maintain. 
 (b) PII shall have the right to control the preparation, filing, prosecution, maintenance and defense thereof and
be responsible for all costs associated with any patents relating to inventions conceived or reduced to practice in the course of the activities under the Development Plan solely by PII’s employees or agents (“PII Patents”). RBX shall
provide PII any reasonable assistance required to perfect the rights defined in Section 7.01. Subject to the last sentence in this Section 7.03(b), if PII decides not to file or maintain any PII Patents on a country-by-country basis or
patent family basis, PII shall give RBX reasonable notice of same and after receipt of such notice, RBX may, at its expense, file or maintain such applications or patents at its own expense, and PII shall assign such patents and patent applications
to RBX that RBX elects to file or maintain. The previous sentence shall not apply to any decision of PII that is based on its determination, in its sole discretion, that the value of a particular PII invention will most likely be maximized by a form
of intellectual property protection other than patent protection, or that a particular filing would detract from the overall value of the patent estate. 
  

 18 

 (c) [*] shall be responsible for all patent costs (including filing fees, maintenance fees, and
outside attorney fees) with respect to each Patent within the RBX Patents and Joint Patents that covers the composition of matter, manufacture or use of the Compound. 
 7.04 Notification. PII shall provide a written report to RBX every second calendar quarter summarizing the status of all RBX Patents and Joint Patents. Such report shall constitute Confidential
Information under Article IX. 
 7.05 Trademarks. PII shall own all trademarks developed by PII used to identify a Licensed Product.

 ARTICLE VIII – PATENTS AND INFRINGEMENT 
 8.01 Infringement of Patent Rights. Each party to this Agreement shall notify the other in writing promptly of any actual, potential or suspected infringement (collectively “alleged
infringement”) of the RBX Patents, Joint Patents or PII Patents of which such Party becomes aware and shall promptly provide the other Party with available evidence of such alleged infringement. PII shall have the first right to take whatever
action it deems appropriate to enforce the RBX Patents, Joint Patents or PII Patents, at its sole cost and expense. If PII does not, within sixty (60) days of receipt of such notice of alleged infringement take any action, or file any suit to
enforce the RBX Patents, Joint Patents and PII Patents against such infringing party in a country in the Territory, RBX may in its discretion, take such action as it deems appropriate, including, without limitation, filing suit against any such
infringing party. If RBX elects to enforce the RBX Patents, RBX shall use good faith efforts in any such proceeding against infringers, shall consult with PII during said enforcement and shall solicit PII’s advice with respect to such
enforcement. Regardless of which Party controls any such enforcement action, RBX and PII shall reasonably cooperate with each other in the planning and execution of any action to enforce the RBX Patents, Joint Patents and PII Patents. The Party
controlling any such enforcement action may not settle or consent to an adverse judgment without the express written consent of the non-controlling Party (such consent not to be unreasonably withheld or delayed). Any damages or other amounts
collected with respect to such action will first be used to reimburse each of the Parties, on a pro rata basis, for its out of pocket costs and expenses; and then, any remaining amount will be distributed [*]% to the Party controlling the
enforcement action and [*]% to the other Party. 
 8.02 Patent Marking. To the extent permitted by applicable laws and regulations, PII
agrees to mark, and to cause any Affiliate, sublicense or Third Party Partner to mark, PII’s Licensed Products (through a marking on containers, packaging or labels, or an Orange Book or like listing) made, sold, or otherwise disposed of by it
or them with any notice of patent rights necessary or desirable under applicable law to enable patent rights to be enforced to their full extent in any country where such Licensed Products are to be sold. 
 8.03 Third Party Infringement Actions. If RBX or any of RBX’s Affiliates or PII or any of PII’s Affiliates, sublicensees or Third Party
Partner shall be sued by, threatened to be sued by or receives a claim from, a Third Party for infringement of a Third Party Patent because of the making, using, selling, offering for sale or importing, or having made, used, sold, offered for sale

  

 [*]
Confidential treatment requested; certain information omitted and filed separately with the SEC. 
  

 19 

 
or imported, the Licensed Products in the Territory, the Party which has been sued, threatened or received a claim (or its Affiliates, or with respect to
PII, its sublicensees, or Third Party Partner, has been sued) shall promptly notify the other Party in writing thereof (each, an “Infringement Action”). If RBX shall receive notice of a certification relating to an abbreviated new drug
application made pursuant to Section 355(j)(2)(A)(viii)(IV) of the FD&C Act, it shall promptly notify PII in writing (a “Paragraph IV Challenge” and collectively with an Infringement Action, “Section 8.03 Actions”). PII
shall have the obligation to undertake control of any Section 8.03 Actions in the Territory which relate to the Compound or a Licensed Product (whether such action was brought against RBX or PII or any of its respective Affiliates or
sublicensees) and RBX shall cooperate in such defense through counsel of its choice at RBX’s expense. PII shall take into account RBX’s comments relating to such Section 8.03 Actions to the extent reasonable. PII may not settle or
consent to an adverse judgment without the expressed prior written consent of RBX (such consent not to be unreasonably withheld, delayed or conditioned). 
 ARTICLE IX – CONFIDENTIAL INFORMATION 
 9.01 Nondisclosure of Confidential Information. All
information disclosed by one Party to the other Party pursuant to this Agreement shall be “Confidential Information.” The Parties agree that during the Term, and for a period of ten (10) years thereafter, a Party receiving
Confidential Information of the other Party will (i) maintain in strictest confidence such Confidential Information to the same extent such Party maintains its own proprietary industrial information of similar kind and value (but at a minimum
each Party shall use commercially reasonable efforts), (ii) not disclose such Confidential Information to any Third Party without prior written consent of the other Party, and (iii) not use such Confidential Information for any purpose
except those permitted by this Agreement. However, such obligation of confidentiality shall not apply to any Confidential Information that: 
 (a) Is publicly disclosed by the disclosing Party, either before or after it is disclosed to the receiving Party hereunder; or 
 (b) Was known to the receiving Party, without obligation to keep it confidential, prior to disclosure by the disclosing Party; or 
 (c) Is subsequently disclosed to the receiving Party by a Third Party lawfully in possession thereof and without obligation to keep it confidential; or 
 (d) Has been published by a Third Party; or 
 (e) Has been independently developed by the
receiving Party without the aid, application or use of all or any part of Confidential Information as evidenced by the receiving Party’s written records. 
 9.02 Authorized Disclosure. A Party may disclose the Confidential Information belonging to the other Party to the extent such disclosure is reasonably necessary in the following instances: 
 (a) Filing or prosecuting Patents relating to Compound; 
  

 20 

 (b) Regulatory Filings and prosecutions of the same; 
 (c) Prosecuting or defending litigation; 
 (d) Complying with applicable governmental regulations; and 
 (e) Disclosure, in connection with the performance of
this Agreement, to sublicensees, a Third Party Partner research collaborators, employees, consultants, or agents, each of whom prior to disclosure must be bound by similar obligations of confidentiality and non-use at least equivalent in scope to
those set forth in this Article IX. 
 The Parties acknowledge that the terms of this Agreement shall be treated as Confidential Information of both Parties.
Such terms may be disclosed by a Party to potential Third Party Partners, investment bankers, investors, potential investors, lenders and other financing parties, provided that they are bound by similar obligations of confidentiality and non-use at
least equivalent in scope to those set forth in this Article IX. In addition, a copy of this Agreement may be filed by either Party with the Securities and Exchange Commission if such filing is required by law or regulation. In connection with any
such filing, such Party shall endeavor to obtain confidential treatment of such terms and other trade secret information to the extent permitted by the Securities and Exchange Commission. 
 9.03 Limitations on Publications. The Parties shall not publish any Confidential Information received from the other Party without the prior written
approval of such Party. 
 ARTICLE X – WARRANTIES 
 10.01 Warranties by RBX. RBX represents and warrants to PII as of the Effective Date and the Option Exercise Date the following: 
 (a) RBX has the full right and power to grant the Option set forth in Section 2.01 and the licenses set forth in Section 3.01 in the
manner and to the extent set forth in this Agreement, free and clear of any adverse assignment, option, grant, right or other encumbrances inconsistent with such grant. 
 (b) RBX or its Affiliates are the sole owners of the RBX Patents, Compound Know-How and Manufacturing Know-How. 
 (c) The chemical formula listed in Section 1.07 accurately defines the compound that is the subject of RBX Intellectual Property provided by RBX to PII. 
 (d) No claims, demands, suits, arbitrations or other adversarial proceedings have been brought or threatened against any Third Party by RBX, which
are related to the RBX Patents or Compound Know-How, or the misappropriation of any RBX trade secrets relating to the Compound. 
 (e)
RBX has not received any written notice by any Third Party of any pending or threatened claim, demand, suit, action, mediation, arbitration, order or other adversarial 

  

 21 

 
proceeding: (i) alleging infringement (or other violation) by RBX of intellectual property or other rights of any Third Party; or (ii) challenging
RBX’s ownership or use of, or the validity, enforcement, registrability or maintenance of, any RBX Patent, Manufacturing Know-How or Compound Know-How owned or licensed by RBX. To RBX’s knowledge, no information contained within RBX
Patents, Manufacturing Know-How or Compound Know-How is being used or enforced in a manner that would reasonably be expected to result in the abandonment, cancellation or unenforceability of such RBX Patents, Manufacturing Know-How or Compound
Know-How. 
 (f) RBX has not entered into any consents, judgments, orders, indemnifications, forbearances to sue, settlement
agreements, licenses or other arrangements that: (i) restrict the RBX’s right to use any RBX Patent, Manufacturing Know-How or Compound Know-How; or (ii) restrict the development or commercialization of the Compound in order to
accommodate a Third Party’s intellectual property rights. 
 (g) Any current and former employee of or consultant to RBX
(“Researcher”) who has contributed to or participated in research and development activities of the Compound has granted to RBX on an exclusive and unrestricted basis, ownership of all intellectual property arising out of such
Researcher’s research and development activities involving the Compound. RBX has not granted or assigned to any Researcher any right to manufacture, have manufactured, assemble, import, or sell the Compound or Licensed Product. 
 (h) To RBX’s knowledge, none of its current employees is obligated under any contract (including licenses, covenants or commitments of any
nature) or other agreement, or subject to any judgment, decree or order of any court or administrative agency, that would interfere or conflict with RBX’s obligations as contemplated under this Agreement. To RBX’s knowledge, RBX has not
utilized any intellectual property or trade secrets owned by any of its employees’ former employer made prior to their employment by RBX. 
 (i) Schedule 1.53 is a true, accurate and complete list of all RBX Patents as of the Effective Date. 
 (j) Except as
described in Schedule 1.53, none of the RBX Patents have been abandoned. RBX has an existing right to file RBX Patents with the United States Patent and Trademark Office. Except as described in Schedule 1.53, all assignment of rights necessary to
vest full and complete ownership of RBX Patents in RBX have been executed by all inventors and correctly recorded in the World Intellectual Property Organization. RBX is not aware of any inventorship disputes regarding any RBX Patents. 

(k) RBX has made available for PII’s review, all documents and certificates requested in writing by PII that have been issued to RBX with
respect to any RBX Patent, including all written documentation evidencing ownership and prosecution. 
 (l) RBX has disclosed to PII
in writing all material information in RBX’s possession that may limit the scope of patentability of RBX Patents. 
  

 22 

 (m) RBX has disclosed to PII all material information it has relating to the Compound, its safety
in animals and humans, its development status and its regulatory status. 
 (n) RBX has disclosed to PII all material information it
has requested in writing relating to the synthesis of the Compound. 
 (o) RBX is validly existing and in good standing under the laws
of the country of its organization and has the corporate and other power and authority to enter into this Agreement. This Agreement has been duly executed and delivered by RBX and constitutes the valid and binding obligation of RBX enforceable
against it in accordance with its terms except as enforceability may be limited by bankruptcy, fraudulent conveyance, insolvency, reorganization, moratorium and other laws relating to or affecting creditors’ rights generally and by general
equitable principles. The execution, delivery and performance of this Agreement have been duly authorized by all necessary action on the part of RBX, its officers and directors. 
 (p) The execution, delivery and performance of this Agreement by RBX (i) are not in contravention of any provisions of the certification of
incorporation or by-laws of RBX, (ii) will not violate any law or regulation or any order or decree of any court or any government instrumentality, (iii) will not violate the terms of any indenture, mortgage, deed of trust, lease,
agreement or other instrument to which RBX is a party or by which RBX or any of its property is bound, and (iv) do not require any filing or registration with or the consent or approval of, any governmental body, agency, authority or any other
person, including, without limitation, the U.S. Federal Trade Commission or the U.S. Department of Justice under the Hart-Scott-Rodino Anti-Trust Improvements Act of 1976, as amended, which has not been made or obtained previously. 
 10.02 Warranties by PII. PII represents and warrants to RBX the following: 
 (a) PII is validly existing and in good standing under the laws of the state of its organization and has the corporate power and authority to enter into this Agreement. This Agreement has been duly executed and
delivered by PII and constitutes the valid and binding obligation of PII, enforceable against it in accordance with its terms except as enforceability may be limited by bankruptcy, fraudulent conveyance, insolvency, reorganization, moratorium and
other laws relating to or affecting creditors’ rights generally and by general equitable principles. The execution, delivery and performance of this Agreement have been duly authorized by all necessary action on the part of PII, its officers
and directors. 
 (b) The execution, delivery and performance of this Agreement by PII (i) are not in contravention of any
provisions of the certification of incorporation or by-laws of PII, (ii) will not violate any law or regulation or any order or decree of any court or any government instrumentality, (iii) will not violate the terms of any indenture,
mortgage, deed of trust, lease, agreement or other instrument to which PII is a party or by which PII or any of its property is bound, and (iv) do not require any filing or registration with or the consent or approval of, any governmental body,
agency, authority or any other person, including, without limitation, the U.S. Federal Trade Commission or the U.S. Department of Justice under the Hart-Scott-Rodino Anti-Trust Improvements Act of 1976, as amended, which has not been made or
obtained previously. 
  

 23 

 (c) There is no (i) action, suit, dispute, proceeding or arbitration (whether by a
governmental agency, division, or otherwise) pending or threatened, or (ii) investigation (formal or informal) pending or threatened against or relating to PII or its Affiliates which, in either case, could reasonably prevent or impair PII from
carrying out its obligations under this Agreement. 
 10.03 Employee Agreements. Each Party represents and warrants that it has entered into a
proprietary information and inventions agreement with each of its employees prior to the time that any such employee shall receive Confidential Information from a Disclosing Party or begin work related to this Agreement. Such agreement shall
minimally set forth employee obligations to assign inventions to the inventing Party and to maintain confidentiality of Confidential Information consistent with the terms of this Agreement. Each Party shall enter into a similar agreement with any
Third Party retained by the Party to perform services hereunder prior to the time that such Third Party receives any Confidential Information from a Disclosing Party or begins work related to this Agreement. 
 ARTICLE XI – TERM AND TERMINATION 
 11.01 Term. Unless otherwise terminated in accordance with the provisions of this Article XI, the licenses granted herein and the obligations assumed hereunder shall commence as of the Option Exercise Date and shall expire on
a country-by-country and Licensed Product-by-Licensed Product basis (the Parties agreeing that each Licensed Product shall have its own term) upon the later to occur of (i) [*] years from the First Commercial Sale in such country of such
Licensed Product, and (ii) the expiry of the last to expire Enforceable Claim covering such Licensed Product in such country. In the event PII does not exercise the Option prior to the expiration of the Option Period, subject to
Section 11.05, this Agreement shall terminate and be of no further legal force or effect. 
 11.02 Material Breach. This Agreement may be
terminated by either Party upon the material default of this Agreement by the other Party. In the event of such material default by a Party (“Defaulting Party”), the other Party (“Non-Defaulting Party”) shall give the Defaulting
Party written notice of the default and its election to terminate this Agreement at the expiration of a cure period of twenty (20) days for payment default and thirty (30) days for non-payment defaults from the date of the notice. If the
Defaulting Party fails to cure the default within the applicable grace period, or if such default is incapable of being cured within such grace period (expressly excluding payment defaults) and the Defaulting Party has failed within such period to
take actions that are reasonably likely to cure such default, provided that in no event shall such default continue beyond one hundred fifty (150) days, then the Non-Defaulting Party may terminate this Agreement by giving written notice to the
Defaulting Party. The termination will be effective upon Defaulting Party’s receipt of such termination notice. All termination rights shall be in addition to and not in substitution for any other remedies that may be available to the
Non-Defaulting Party. Termination pursuant to this section will not relieve the Defaulting Party from liability and damages to the Non-Defaulting Party for default. Waiver by either Party of a single default or a succession of defaults will not
deprive such Party of any right to terminate this Agreement arising by reason of any subsequent default. Notwithstanding the foregoing, PII shall not be considered in material default under this Agreement if such material default results from a
Licensed Product Manufacturing Failure. 
  

	[*]	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  

 24 

 11.03 Termination for Failure to Meet Key [*] Milestones. RBX may terminate this Agreement upon thirty
(30) days’ written notice to PII in the event that any one or more of the following milestones have not been achieved within six (6) months of the date corresponding to such milestone as follows: 
  

					
	 	  	 Milestone
	  	 Date

			
	1.	  	[*]	  	[*]
			
	2.	  	[*]	  	[*]
			
	3.	  	[*]	  	[*]
			
	4.	  	[*]	  	[*]
			
	5.	  	[*]	  	[*]
			
	6.	  	[*]	  	[*]

 provided; however, that the period within which a milestone must be achieved as provided above, and each
subsequent milestone thereafter, will be extended to the extent of the delay in the completion of the applicable milestone that was caused by (i) RBX’s delay in compliance with its obligations provided in Sections 4.05 and 4.07 of this
Agreement, (ii) a Force Majeure event or (iii) an Interfering Event. PII shall use Diligent Efforts to achieve each of the Milestones provided above as soon as practicable and shall, in the event of a delay, provide RBX detailed
information on a monthly basis describing the reason for the delay, the actions being taken to overcome the delay and the estimated time to complete the delayed Milestone. 
 11.04 Termination for Insolvency/Bankruptcy. It either PII or RBX (i) makes a general assignment for the benefit or creditors or becomes insolvent; (ii) files an insolvency petition in
bankruptcy; (iii) petitions for or acquiesces in the appointment of any receiver, trustee or similar officer to liquidate or conserve its business or a substantial part of its assets; (iv) commences under the laws of any jurisdiction any
proceeding involving its insolvency, bankruptcy, reorganization, adjustment of debt, dissolution, liquidation or any other similar proceedings for the release of financially distressed debtors; or (v) becomes a party to any proceeding or action
of the type described in (iii) or (iv) and such proceeding or action remains undismissed or unstayed for a period of more than sixty (60) days, then the other party may by written notice terminate this Agreement in its entirety with
immediate effect. 
 11.05 Voluntary Termination by PII. PII shall have the right to terminate this Agreement in the course of Development upon
giving RBX at least sixty (60) days prior written notice, if PII, in its sole discretion, determines that further Development or commercialization of Licensed Product is no longer viable for safety, efficacy or manufacturing reasons, or, if in the
opinion of PII, the Licensed Product is no longer viable for commercial reasons. In such event, PII shall, to the extent it is legally required to do so, diligently finalize any clinical trial it has initiated and issue the corresponding final
report and any other pertinent documents (including providing copies of same to RBX) in compliance with applicable regulatory requirements. In the event PII exercises the right of termination provided in this Section 11.05 prior to the
completion of any 
  

	[*]	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  

 25 

 
[*] for the Licensed Product other than (i) for safety, or efficacy reasons relating to the Licensed Product, (ii) for a material Licensed Product
Manufacturing Failure, or (iii) for breach of this Agreement by RBX, within thirty (30) days of the provision of PII’s written notice of termination to Ranbaxy as provided in this Section 11.05, PII shall remit to Ranbaxy a
termination payment of [*]. 
 11.06 Rights of RBX Upon Early Termination. If PII terminates this Agreement pursuant to
Section 11.05 or if Ranbaxy terminates this Agreement under Sections 11.02, 11.03 and/or 11.04, PII shall: 
 (a) irrevocably lose
any and all licenses granted to PII by RBX pursuant to this Agreement, including, without limitation, pursuant to Section 3.01, which licenses shall terminate and be of no further force or effect; 
 (b) be deemed to have automatically granted to RBX (without any further action required by PII) an irrevocable, fully-paid, worldwide, exclusive
license to the Joint Patent Rights and the Joint Inventions to develop, make, use and sell any Licensed Product; 
 (c) be deemed to
have automatically granted to RBX (without any further action required by PII) an irrevocable, worldwide, non-exclusive license under the PII Patents to develop, make, use and sell any Licensed Product; 
 (d) promptly, but in no event later than thirty (30) days from the effective date of termination, provide RBX with copies of all PII
Information and PII shall be deemed to have automatically granted to RBX (without any further action required by PII) the right to use such information to develop, make, use and sell (including, without limitation, obtaining Regulatory Approval) any
Licensed Product(s); 
 (e) PII shall be deemed to have automatically conveyed to RBX (without any further action required by PPD) all
of PII’s, its Affiliates’ and its Third Party Partner’s right, title and interest in and to any and all Regulatory Approvals (including related Regulatory Documentation) then pending or otherwise obtained by PII, its Affiliates or its
Third Party Partner relating to the Compound or any Licensed Product(s); 
 (f) PII shall execute and deliver and cause its Affiliates
and its Third Party Partner to execute and deliver, such other instruments of conveyance and transfer and take such other action as RBX may reasonably request to more effectively convey, transfer to and vest in RBX the information and Regulatory
Approvals described above; 
 (g) not later than thirty (30) days from the termination of this Agreement, deliver to RBX
(i) all original patent files relating to the RBX Patents, (ii) copies of the PII Patents (including PII Patent applications) and (iii) copies of the patent files relating to the Joint Patents, all at PII’s cost and expense;

 (h) destroy and not retain any copies of Confidential Information provided by RBX pursuant to this Agreement; 
  

 [*] Confidential
treatment requested; certain information omitted and filed separately with the SEC. 
  

 26 

 (i) ensure that any Partnering Agreement will reflect the requirements of this Section 11.06;
and 
 In the event PII exercises its right of termination under Section 11.05, PII shall have no further liability or obligation to RBX under the terms
of this Agreement, except as set forth in Sections 11.05, 11.06 and 11.08. 
 11.07 Early Termination by PII. If PII terminates this Agreement
under Sections 11.02, 11.04 or 11.05, any license grant by RBX to PII pursuant to this Agreement, including, without limitation, as set forth in Section 3.01 shall automatically terminate and be of no further legal force or effect. 

11.08 Residual Obligation upon Termination. Termination of this Agreement for any reason whatsoever will not release or discharge the Parties from the
performance of any obligation, the payment of any debt or responsibility for any liability which may have previously accrued and remains to be performed, paid or discharged, at the date of such termination. However, upon termination no further
obligations under this Agreement shall be incurred by the Parties. Moreover, termination of this Agreement shall not release either Party of the obligations of confidentiality set forth in Section 9.01. Sections 5.07, 6.02, 6.03, 7.01, 7.02,
7.05, 8.03 (relating to any Section 8.03 Actions commended prior to the date of such termination), 11.06, 11.07, 12.01, 12.02, 12.03, 12.07, 12.09, 12.15, 12.16, and 12.17 and Article I shall survive any expiration or termination of this
Agreement. 
 11.09 Remaining Licensed Product. Upon any termination of this Agreement, PII shall have the right for twelve (12) months to
sell all Licensed Product then on hand, and to complete all orders for such Licensed Product then on hand, and royalties shall be paid to RBX with respect to such Licensed Product as though this Agreement had not terminated. 
 ARTICLE XII – MISCELLANEOUS 
 12.01.
Indemnification. 
 (a) RBX Indemnification of PII. RBX shall indemnify, hold harmless and defend PII, its permitted
assignees, and its and their officers, employees, agents, sublicensees, a Third Party Partner, Affiliates, and/or contractors against any and all claims, demands, suits, losses, damages, settlements, costs, fees and expenses of any nature
whatsoever, including without limitation reasonable attorney’s fees, expert witness fees and court costs (“Claim”) resulting from or arising out of (i) any material breach by RBX of a representation or warranty contained in this
Agreement; (ii) any material breach of this Agreement by RBX; (iii) any failure by RBX to comply in all material respects with applicable laws in connection with the performance of its obligations under this Agreement; (iv) the
negligence or willful misconduct of RBX in the performance of this Agreement; and/or (v) the development, manufacture, packaging, labeling, handling, storage, transportation, use, distribution, promotion, marketing and sale of any AB Rated
Product by RBX or any of its Affiliates or designated Third Parties for any AB Rated Product [*]; in each case except to the extent such Claims result from the gross negligence or willful misconduct of PII in the performance of this Agreement.

  

 [*] Confidential
treatment requested; certain information omitted and filed separately with the SEC. 
  

 27 

 (b) PII Indemnification of RBX. PII shall indemnify, hold harmless and defend RBX, its
permitted assignees, and its and their officers, employees, agents, sublicensees, Affiliates and/or contractors against any and all claims, demands, suits, losses, damages, costs, fees and expenses of any nature whatsoever, including, without
limitation, reasonable attorney’s fees, expert witness fees and court costs (“Claim”) resulting from or arising out of (i) the Development, manufacture, packaging, labeling, handling, storage, transportation, use, distribution,
promotion, marketing and sale by PII or its Affiliates, any of their sublicensees (including sublicensees of such sublicensees), or a Third Party Partner, distributors or agents of the Compound and any Licensed Products in the Territory and the
recall of any Licensed Products; (ii) any use, handling, storage, testing, transportation, distribution, manufacturing, formulation or sale of the RBX [*]; (iii) any alleged or actual infringement or misappropriation of a Third
Party’s intellectual property in connection with the Development, manufacture and/or commercialization of the Compound or any Licensed Product including, without limitation, any amounts paid or payable to a Third Party pursuant to
Section 8.03; (iv) the manufacture of the Drug Substance, CTM Product and/or Licensed Product by PII, its Affiliates, any sublicensee, Third Party Partner of PII or Third Party; (v) any material breach by PII of a representation or
warranty contained in this Agreement; (vi) any material breach of this Agreement by PII or its Affiliates, sublicensees or Third Party Partner of PII; (vii) any injury to or death of any person from the use of any Drug Substance, CTM
Product, or Licensed Product; (viii) any failure by PII to comply in all material respects with applicable laws in connection with the performance of its obligations or the exercise or its rights under this Agreement; and/or (ix) the
negligence or willful misconduct of PII or its Affiliates, sublicensees or Third Party Partner of PII in the performance of this Agreement; in each case except to the extent such Claims result from the gross negligence or willful misconduct of RBX
in the performance of this Agreement. 
 (c) Indemnification Procedure. 
 (i) If any action is brought against a party entitled to indemnification under Section 12.01(a) or 12.01(b), as applicable, (each, an
“Indemnified Party”), such Indemnified Party or Parties shall promptly notify the party obligated to provide indemnification (an “Indemnifying Party”) in writing of the institution of such action. 
 (ii) Promptly upon receipt of notice pursuant to subparagraph (a) above, the Indemnifying Party shall promptly assume the defense of such action,
including, without limitation, the employment of counsel reasonably satisfactory to such Indemnified Party or Parties, and payment of expenses. An Indemnified Party or Parties shall have the right to employ its or their own counsel in any such case,
but the fees and expenses of such counsel shall be at the expense of such Indemnified Party or Parties, unless: (A) the employment of such counsel shall have been authorized in writing by the Indemnifying Party in connection with the defense of
such action; or (B) the named parties to such action include both the Indemnified Party or Parties and the Indemnifying Party and such Indemnified Party or Parties shall have reasonably concluded that there may be one or more legal defenses
available to it or them or to other Indemnified Parties which are different from, or in addition to, those available to the Indemnifying Party. In either of the foregoing events, such fees and expenses shall be borne by 
  

 [*] Confidential
treatment requested; certain information omitted and filed separately with the SEC. 
  

 28 

 
the Indemnifying Party and the Indemnifying Party shall not have the right to direct the defense of such action on behalf of the Indemnified Party or
Parties. Notwithstanding anything to the contrary set forth herein, under no circumstances shall the Indemnifying Party be obligated to assume responsibility for the expenses for more than one counsel for all of the Indemnified Parties as a group.

 (iii) Notwithstanding anything contained in this Section 12.01(c) to the contrary, the Indemnifying Party shall not be liable for any
settlement of any such Claim or action effected without its written consent, which consent shall not be unreasonably withheld. The Indemnifying Party shall have the right to settle or compromise any action, or permit a default or consent to the
entry of judgment in, or otherwise seek to terminate, any pending or threatened action, in respect of which indemnity may be sought hereunder (whether or not any Indemnified Party is a party thereto), provided such settlement, compromise, consent,
or termination includes a disclaimer of any fault of the Indemnified Party and an unconditional release of each Indemnified Party from all liability in respect of such action. In the event such an unconditional release is not obtainable for each
Indemnified Party, then the Indemnifying Party must obtain the prior written consent of any Indemnified Party not so released before the Indemnifying Party may enter into such settlement, compromise, consent or termination, which consent shall not
be unreasonably withheld or delayed. 
 (d) Limitation on Liability. IN NO EVENT SHALL EITHER PARTY OR ITS AFFILIATES, OR THEIR
DIRECTORS, OFFICERS, EMPLOYEES OR AGENTS BE LIABLE TO THE OTHER PARTY FOR ANY INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY OR CONSEQUENTIAL DAMAGES, WHETHER BASED UPON A CLAIM OR ACTION OF CONTRACT, WARRANTY, NEGLIGENCE, STRICT LIABILITY OR OTHER TORT,
OR OTHERWISE ARISING OUT OF THIS AGREEMENT; PROVIDED, HOWEVER, THAT THIS LIMITATION WILL NOT LIMIT THE INDEMNIFICATION OBLIGATIONS OF SUCH PARTY UNDER THE PROVISIONS OF THIS ARTICLE XII FOR SUCH DAMAGES CLAIMED BY A THIRD PARTY (EXPRESSLY EXCLUDING
ANY SUBLICENSEE, AFFILIATE OR THIRD PARTY PARTNER OF PII). 
 (e) Payment of Indemnification. Upon the final, nonappealable
determination of liability and the amount of the indemnification payment under this Article, the indemnifying Party will pay such amount to the Indemnified Party in immediately available funds within thirty (30) days after such determination.

 12.02. Product Recalls and Insurance. 
 (a) Product Recalls. PII shall oversee and handle, at its own cost and expense, all physical aspects relating to any withdrawal or recall of the Licensed Products sold by PII or its Affiliates, their respective sublicensees or
a Third Party Partner in the Territory; 
 (b) Insurance. During the term of this Agreement and for a period of five
(5) years after its expiration or earlier termination, each Party shall obtain, at its sole cost and expense, product liability insurance, or shall set up, at its sole cost and expense, a self insurance arrangement, that meets the following
requirements: 
 (i) the insurance shall insure such Party against all liability related to the Products (whether that Party’s liability
arises from its own conduct or by virtue of its participation in this Agreement), including liability for bodily injury, property damage, wrongful death, and any contractual indemnity obligations imposed by this Agreement; and 
  

 29 

 (ii) the insurance shall be in amounts, respectively, that are reasonable and customary in the United
States in the pharmaceutical industry, but in no event shall the product liability insurance maintained by each Party cover less than [*] per occurrence (or claim) and an annual aggregate of [*]. Each Party shall provide written proof of the
existence of such insurance to the other Party upon request. 
 12.03. Arbitration. 
 (a) Pre-Arbitration Efforts. If a dispute arises between the Parties as to the interpretation or performance of any of the provisions of
this Agreement or as to matters related to but not covered by this Agreement, then the Parties shall consult initially to try to resolve the matter amicably. If they shall not be capable of resolving the matter within thirty (30) days of the
dispute arising, the matter shall be dealt with in accordance with the provisions of Section 12.03(b). 
 (b) Arbitration
Procedures. All disputes arising out of or in connection with the Agreement shall be settled by final and binding arbitration by the American Arbitration Association (“AAA”), under its commercial rules then in effect except as
provided herein. The arbitration will be conducted in New York, NY or such other geographically neutral site within the United States that is mutually agreed by the Parties. All proceedings shall be held in English and a transcribed record prepared
in English. The parties shall choose, by mutual agreement, one arbitrator within twenty (20) days of the filing of an arbitration demand with the AAA. If the parties are unable to appoint an arbitrator within the time herein provided or any
extension of time that is mutually agreed on, one arbitrator will be appointed by PII, one arbitrator will be appointed by RBX, and the third arbitrator will be appointed by the two arbitrators within thirty (30) days of the date on which the
initial period for appointment of a sole arbitrator by mutual agreement lapsed. The award rendered by the arbitrator shall include all costs of arbitration, reasonable attorneys’ fees and reasonable costs for expert and other witnesses, and
judgment on such award may be entered in any court having jurisdiction thereof. Nothing in this Agreement shall be deemed as preventing either party from seeking injunctive relief (or any other provisional remedy) from any court having jurisdiction
over the Parties and the subject matter of the dispute as necessary to protect either Party’s name, proprietary information, trade secrets, know-how or any other proprietary right. If the issues in dispute involve scientific or technical
matters, any arbitrator chosen hereunder shall have educational training and/or experience sufficient to demonstrate a reasonable level of knowledge in the field of biotechnology. 
 12.04. Amendment. This Agreement may not be amended, supplemented or otherwise modified except by an instrument in writing signed by an authorized representative of the Parties. 
  

 [*] Confidential
treatment requested; certain information omitted and filed separately with the SEC. 
  

 30 

 12.05. Entire Agreement. The Parties acknowledge and agree that this Agreement includes the Schedules and
constitutes the entire agreement and understanding relating to the subject matter of this Agreement. As such, this Agreement supersedes all previous communications, proposals, representations and agreements, whether oral or written, including the
Confidentiality Agreement, relating to the subject matter of this Agreement. 
 12.06. Severability. Each Party agrees that, should any
provision of this Agreement be determined by a court of competent jurisdiction to violate or contravene any applicable law or policy, such provision will be modified by the court to the extent necessary to comply with the applicable law or policy,
and such modified provision and the remainder of the provisions hereof will continue in full force and effect; and if such provision cannot be so modified, it shall be severed from this Agreement and the remaining provisions shall be equitably
adjusted if necessary, and shall remain in full force and effect. 
 12.07. Waiver. The waiver of a breach hereunder may be affected only by a
writing signed by the waiving Party and shall not constitute a waiver of any other breach. Any delay in enforcing a Party’s rights under this Agreement or any waiver as to a particular default or other matter shall not constitute a waiver of
such Party’s rights to the future enforcement of its rights under this Agreement, excepting only as to an express written and signed waiver as to a particular matter for a particular time period. 
 12.08. Notices. Any notice required or permitted to be given or delivered hereunder or by reason of the provisions of this Agreement shall be in writing
and shall be deemed to have been properly served if: (a) delivered personally, (b) delivered by a recognized overnight courier service instructed to provide next-day delivery, (c) sent by certified or registered mail, return receipt
requested and first class postage prepaid, or (d) sent by facsimile transmission followed by confirmation copy delivered by a recognized overnight courier service the next day. Such notices, demands and other communications shall be sent to the
addresses set forth below, or to such other addresses or to the attention of such other person as the recipient Party has specified by prior written notice to the sending Party. Date of service of such notice shall be: (i) the date such notice
is personally delivered or sent by facsimile transmission (with issuance by the transmitting machine of confirmation of successful transmission), (ii) three days after the date of mailing if sent by certified or registered mail, or
(iii) one day after date of delivery to the overnight courier if sent by overnight courier. Unless otherwise specified in writing, the mailing addresses of the Parties shall be as described below. 
  

			
	 For:
	    	Pharmaco Investments, Inc.
		    	3151 South 17th Street
		    	Wilmington, NC 28412
		    	Facsimile: (910) 343-5920
		    	 Attn: Chief Executive Officer

		
		    	With a copy to:
		    	Pharmaco Investments, Inc.
		    	3151 South 17th Street
		    	Wilmington, NC 28412
		    	Facsimile: (910) 343-5920
		    	 Attn: General Counsel

		
	 For:
	    	Ranbaxy Laboratories Ltd.
		    	Plot 90 Sector 32
		    	Gurgaon 1222001 (Haryana) India
		    	Facsimile:
		    	 Attn:

  

 31 

 12.09. Governing Law. This Agreement shall be governed by, and construed in accordance with, the laws of
the State of New York, United States, except any choice of law shall be determined in accordance with the applicable laws of the countries in which patents encompassed within the scope of this Agreement have issued. Any action, suit or other legal
proceeding which either party may commence to resolve any matter arising under or relating to any provision of this Agreement shall be commenced only in the state or federal courts located in the State of New York, United States, and the parties
hereby consent to the jurisdiction of such court with respect to any such action, suit or proceeding. 
 12.10. Assignability. This Agreement
and the licenses granted herein shall be binding upon and inure to the benefit of the Parties and their respective successors in interest, whether by acquisition, merger or purchase of all or substantially all of the assets of such Party. Except as
contemplated in the foregoing, neither Party shall assign this Agreement or any benefit and/or burden hereunder without prior written consent of the other Party, provided that either Party will have the right to assign this Agreement and its
benefits and burdens hereunder to an Affiliate, or to a successor in interest (whether by acquisition, merger or sale of all or substantially all its assets), without obtaining the consent of the other party. Nothing in this Section 12.10 shall
be deemed to prevent PII from subcontracting its obligations under this Agreement to any Third Party, which PII shall have the right to do in its discretion subject to Section 3.02. 
 12.11. Release of Information. Unless otherwise mutually agreed by the Parties, the Parties agree to issue, within two (2) business days from the Option Exercise Date, a mutually agreed press
release relating to the transactions contemplated by this Agreement. No Party to this Agreement may otherwise release any information to any Third Party regarding the terms of this Agreement without the prior written consent of the other Party.
Without limitation, this prohibition applies to press releases, educational and scientific conferences, promotional Licensed Products, governmental filings, and discussions with public officials and the media. This provision, however, does not apply
to any publications or disclosures which may be required: (i) by law, including requests for a copy of this Agreement or related information by tax authorities; (ii) for recording purposes; and (iii) by investment bankers, lawyers,
accountants and other professional advisors (provided such disclosure is made under strict confidentiality and the detail of terms disclosed is kept to the absolute minimum required by such professionals). Each Party agrees that it shall fully
cooperate with the other with respect to all disclosures regarding this Agreement to the Securities and Exchange Commission and any other governmental or regulatory agencies, including requests for confidential treatment of proprietary information
of either Party included in any such disclosures. 
  

 32 

 12.12. Relationship of the Parties. The Parties are independent contractors and nothing in this Agreement
is intended or shall be deemed to constitute or create a partnership, agency or employer-employee relationship between the Parties. 
 12.13.
Dollars. All references to “dollars” hereunder are to United States dollars. 
 12.14. Jointly Prepared. This Agreement
has been prepared jointly and shall not be strictly construed against either Party. 
 12.15. Headings. The captions or headings of the
Sections are inserted only as a matter of convenience or for reference and shall have no effect on the meaning of the provisions hereof. 
 12.16.
Counterparts. This Agreement may be executed in one or more counterparts, including by facsimile, each of which shall be an original, but all of which taken together shall constitute one and the same agreement. 
 12.17. Schedules. Each Schedule attached hereto shall be incorporated into and be a part of this Agreement. 
 12.18. Force Majeure. Both Parties, and any Third Party vendors or any sublicensee or Third Party Partner of PII, shall be excused from the performance of
their obligations under this Agreement to the extent that such performance is prevented, in whole or in part, by Force Majeure events and the nonperforming Party promptly provides notice of the prevention to the other Party. Such excuse shall be
continued so long as the condition constituting Force Majeure continues and the nonperforming Party takes reasonable efforts to remove the condition; provided, however, the obligation to make payment of any payment that is due and
owing hereunder shall not be delayed by the payer because of a Force Majeure affecting the payer. 
 12.19. PPD Guarantee. PPD hereby
unconditionally and irrevocably guarantees to RBX the performance of all of the obligations of PII under this Agreement, including, without limitation, the due and prompt payment by PII of any amounts payable under Article V. 
 12.20. No Third Party Beneficiary. No Third Party is or shall be construed to be a third party beneficiary of any provision of this Agreement. 

IN WITNESS WHEREOF, the Parties have executed this Agreement through duly authorized representatives as of the date first set forth herein. 
 [The Next Page is the Signature Page] 
  

 33 

							
	PHARMACO INVESTMENTS, INC.	    	RANBAXY LABORATORIES LTD.
				
	By:	 	  
	    	By:	 	  

				
	Name:	 	  
	    	Name:	 	  

				
	Title:	 	  
	    	Title:	 	  

 PPD, by its signature below, executes and delivers this Agreement to RBX for the sole and limited purpose of
agreeing to be bound by Section 12.19. 
 PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. 
  

			
	By:	 	  

		
	Name:	 	  

		
	Title:	 	  

  

 34 

 SCHEDULE 1.13 
 DEVELOPMENT PLAN 
 [*] 
  

 [*] Confidential treatment requested; certain information omitted and
filed separately with the SEC. 

 SCHEDULE 1.53 
 RBX PATENTS 
 [*] 
  

 [*] Confidential treatment requested; certain information omitted and filed separately with the SEC.

 SCHEDULE 4.05 
 RBX Know-How 
 [*] 
  

 [*] Confidential treatment requested; certain information omitted and filed separately with the SEC.Form of Indemnification Agreement

 Exhibit 10.10 
 INDEMNIFICATION AGREEMENT 
 AGREEMENT, effective as of
                            , [2006] between Rayonier Inc., a North Carolina corporation (the
“Company”), and
                                        
         (the “Indemnitee”). 
 WHEREAS, it is essential that the
Company attract and maintain responsible, qualified directors and corporate officers; and 
 WHEREAS, the Indemnitee is a
director or corporate officer of the Company; and 
 WHEREAS, both the Company and the Indemnitee recognize the increased
risk of litigation and other claims being asserted against directors and corporate officers of public companies in today’s environment, as well as the possibility that in certain control situations a threat of litigation may be employed to
deter them from exercising their best judgment in the interest of the Company, and the consequent need to allocate the risk of personal liability through indemnification and insurance; and 
 WHEREAS, the Amended and Restated Articles of Incorporation of the Company (the “Charter”) requires the Company to indemnify
and advance expenses to its directors and officers to the fullest extent permitted from time to time by law and the Indemnitee is willing to serve or continue to serve as a director or corporate officer of the Company provided that he be indemnified
as provided herein; and 
 WHEREAS, in recognition of the Indemnitee’s need for substantial protection against personal
liability and of the Indemnitee’s reliance on the Charter, and in part to provide Indemnitee with specific contractual assurance that the protection promised by the Charter will be available to the Indemnitee (regardless of, among other things,
any amendment to or revocation of the Charter or any change in the composition of the Company’s Board of Directors or any acquisition transaction involving the Company), the Company wishes to provide in this Agreement for the indemnification of
and the advancement of expenses to the Indemnitee to the fullest extent permitted by law and as set forth in this Agreement, and, to the extent insurance is maintained, for the continued coverage of Indemnitee under the Company’s directors and
officers liability insurance policies. 
 NOW, THEREFORE, in consideration of the premises and of the Indemnitee continuing
to serve the Company directly or, at its request, another enterprise, and intending to be legally bound hereby, the parties hereto do hereby covenant and agree as follows: 

 1. Certain Definitions 
 (a) Change in Control: Shall mean the occurrence of any one or more of the following events: (i) subject to the conditions contained in the final paragraph of this definition, the
filing of a report on Schedule 13D with the Securities and Exchange Commission pursuant to Section 13(d) of the Securities Exchange Act of 1934 (the “Act”) disclosing that any person, other than the Company or any employee
benefit plan sponsored by the Company, is the beneficial owner (as the term is defined in Rule 13d-3 under the Act) directly or indirectly, of securities representing twenty percent or more of the total voting power represented by the
Company’s then outstanding Voting Securities (calculated as provided in paragraph (d) of Rule 13d-3 under the Act in the case of rights to acquire Voting Securities); or (ii) the purchase by any person, other than the Company or
any employee benefit plan sponsored by the Company, of shares pursuant to a tender offer or exchange offer to acquire any Voting Securities of the Company (or securities convertible into such Voting Securities) for cash, securities or any other
consideration, provided that after consummation of the offer, the person in question is the beneficial owner, directly or indirectly, of securities representing twenty percent or more of the total voting power represented by the Company’s then
outstanding Voting Securities (all as calculated under clause (i)); or (iii) the approval by the shareholders of the Company of (A) any consolidation or merger of the Company in which the Company is not the continuing or surviving
Company (other than a merger of the Company in which holders of Common Shares of the Company immediately prior to the merger have the same proportionate ownership of Common Shares of the surviving company immediately after the merger as immediately
before), or pursuant to which Common Shares of the Company would be converted into cash, securities or other property, or (B) any sale, lease, exchange or other transfer (in one transaction or a series of related transactions) of all or
substantially all the assets of the Company; or (iv) a change in the composition of the Board of Directors of the Company at any time during any consecutive twenty-four month period such that “continuing directors” cease for any
reason to constitute at least a 70% majority of the Board. For purposes of this definition of “Change in Control,” the term “Voting Securities” means any securities of the Company which vote generally in the election of members
of the Board of Directors and the term “continuing directors” means those members of the Board who either were directors at the beginning of a consecutive twenty-four month period or were elected during such period by or on the nomination
or recommendation of at least a 70% majority of the then-existing Board. 
 So long as there has not been a Change in Control
within the meaning of clause (iv) above, the Board of Directors may adopt by a majority vote of the “continuing directors” a resolution to the effect that the occurrence of an event described in clause (i) (a
“Clause (i) Event”) does not constitute a “Change in Control” (an “Excluding Resolution”) or a resolution to the effect that the occurrence of a Clause (i) Event does constitute a “Change in Control”
(an “Including Resolution”). The adoption of an Excluding Resolution with respect to any Clause (i) Event shall not deprive the Board of Directors of the right to adopt an Including Resolution with respect to such Clause (i)
Event at a later date. A Clause (i) Event shall not in and of itself constitute a “Change in Control” until the earlier of (x) the effective date of an Including Resolution with respect thereto or (y) the passage of a period
of five (5) business 

  

 2 

 
days after the Company’s receipt of a copy of the subject report on Schedule 13D in compliance with Rule 13d-7 under the Act without an Excluding
Resolution having been adopted with respect thereto; notwithstanding the adoption of an Excluding Resolution within the five business-day period referred to in (y), an Including Resolution may subsequently be adopted with respect to the relevant
Clause (i) Event while it continues to exist, in which event a “Change in Control” shall be deemed to have occurred for purposes of this definition upon the effective date of such Including Resolution. The provisions of this second
paragraph of the definition of “Change in Control” relate only to situations where a Clause (i) Event has occurred and no Change in Control within the meaning of clause (ii), (iii) or (iv) of the preceding paragraph has
occurred, and nothing in this paragraph shall derogate from the principle that the occurrence of an event described in clause (ii), (iii) or (iv) of the preceding paragraph shall be deemed an immediate Change in Control regardless of
whether or not a Clause (i) Event has occurred and an Excluding Resolution or Including Resolution become effective. 
 (b) Expenses: Expenses of every kind incurred in connection with a Proceeding, including counsel fees. Expenses shall include, without limitation, court costs, transcript costs, fees of experts, witness fees, travel expenses,
duplicating costs, printing and binding costs, telephone and fax charges, postage, delivery service charges, costs associated with procurement of surety bonds or loans or other costs associated with the stay of a judgment, penalty or fine, and all
other disbursements or expenses of the types customarily incurred in connection with prosecuting, defending, preparing to prosecute or defend, investigating, or being or preparing to be a witness in a Proceeding. 
 (c) Independent Counsel: A lawyer or law firm that is experienced in matters of corporation law and neither presently is, nor in
the past five years has been, retained to represent: (i) the Company or the Indemnitee in any matter, or (ii) any other party to the Proceeding giving rise to a claim for indemnification hereunder. Notwithstanding the foregoing, the term
“Independent Counsel” shall not include any person who, under the applicable standards of professional conduct then prevailing, would have a conflict of interest in representing either the Company or the Indemnitee in an action to
determine Indemnitee’s rights under this Agreement. Independent Counsel may be, but need not be, a member of the bar of North Carolina. 
 (d) Proceeding: Any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative, or investigative and whether formal or informal. A “Proceeding” may be
instituted by another party, or by or in the right of the Company, or by the Indemnitee. The term “Proceeding” shall also include any preliminary inquiry or investigation that the Indemnitee in good faith believes might lead to the
institution of a “Proceeding”. 
 (e) Reviewing Party: Any appropriate person or body consisting of
(i) a member or members of the Company’s Board of Directors or (ii) any other person or body duly appointed by the Board who is not a party to the particular Proceeding for which the Indemnitee is seeking indemnification, or
(iii) Independent Counsel. 
  

 3 

 (f) Voting Securities: Any securities of the Company which vote generally in the
election of directors. 
 2. Term of Agreement: This Agreement shall continue until and terminate upon the later of
(i) the tenth anniversary after the date that the Indemnitee shall have ceased to serve as a director or officer of the Company (or in any other capacity in respect of which he has rights of indemnification hereunder); or (ii) the final
termination of all pending Proceedings in respect of which Indemnitee is granted rights of indemnification or advancement of Expenses hereunder, including any Proceeding commenced by the Indemnitee to enforce the Indemnitee’s rights under this
Agreement. 
 3. Right to Indemnification and Advance; How Determined. 
 (a) In the event the Indemnitee was, is or becomes a party to or witness or other participant in, or is threatened to be made a party to
or witness or other participant in, a Proceeding by reason of (or arising in whole or in part out of) Indemnitee’s present or former status as a director, officer or fiduciary of the Company, or Indemnitee having served at the request of the
Company as a director, officer, employee, trustee, agent or fiduciary of another corporation, joint venture, employee benefit plan, trust or other enterprise, the Company shall indemnify the Indemnitee to the fullest extent permitted by law in
effect on the date hereof (and to such greater extent as applicable law may hereafter permit) against the obligation to pay any and all Expenses, judgments, settlements, penalties, or fines (including any interest assessed, and including any excise
tax assessed with respect to an employee benefit plan) incurred on account of or with respect to such Proceeding. Such indemnification shall be made as soon as practicable, but in any event no later than sixty days after written demand is presented
to the Secretary of the Company. This Agreement shall be effective as well with respect to any such Proceedings which relate to acts or omissions occurring or allegedly occurring prior to the execution of this Agreement, and regardless of whether
the Company may have been incorporated in a different jurisdiction at the time of such acts or omissions. 
 (b) In
connection with any such Proceeding, if so requested by the Indemnitee, the Company shall advance, within two business days of such request, any and all reasonable Expenses to the Indemnitee (an “Expense Advance”). An Expense Advance shall
be made without awaiting the results of the Proceeding giving rise to the Expenses or the outcome of any further Proceeding to determine the Indemnitee’s right to indemnification hereunder, and without making any preliminary determination as to
the Indemnitee’s state of mind at the time of the activities in question. 
 (c) Notwithstanding the foregoing, the
Company shall not be obligated to indemnify under this Section 3 a person made a party to a Proceeding if (i) the Indemnitee is not successful within the meaning of Section 6 and (ii) the appropriate Reviewing Party specified in
subsection (e) below shall have affirmatively determined (in a written opinion in any case in which Independent Counsel referred to in Section 4 hereof is involved, a copy of which shall be delivered to the Indemnitee) that the
Indemnitee’s activities in question were at the 

  

 4 

 
time taken known or believed by him to be clearly in conflict with the best interests of the Company. The obligation of the Company promptly to make an
Expense Advance(s) pursuant to subsection (b) above is unqualified, is not subject to any means or other credit test, and shall be enforceable by the Indemnitee in summary judicial proceedings; but shall be subject, however, to the condition
subsequent that if, when and to the extent the Reviewing Party may subsequently determine that the Indemnitee’s activities were at the time taken known or believed by him to be clearly in conflict with the best interests of the Company, then
the Company shall be entitled to be reimbursed by the Indemnitee for all such amounts theretofore advanced. The obligation of the Indemnitee to make such reimbursement shall be unsecured and without interest. The Indemnitee hereby undertakes so to
reimburse the Company, the receipt of which unsecured and interest free undertaking is hereby accepted by the Company as the sole condition of advancing the Indemnitee’s Expenses pursuant to subsection (b) above. If the Indemnitee has
commenced legal or arbitration proceedings to secure a determination that the Indemnitee should be indemnified hereunder, the Indemnitee shall not be required to reimburse the Company for any Expense Advance until a final determination is made by
the court or the arbitrators as the case may be that the Indemnitee’s activities were at the time taken known or believed by him to be clearly in conflict with the best interests of the Company. 
 (d) Notwithstanding anything in this Agreement to the contrary, prior to a Change in Control, the Indemnitee shall not be entitled to
indemnification pursuant to this Agreement in connection with any Proceeding initiated by the Indemnitee unless the Board of Directors has authorized or consented to the initiation of such Proceeding. For purposes of the foregoing sentence, a
Proceeding shall not be deemed to have been “initiated” by the Indemnitee where its primary purpose is to enforce the Indemnitee’s rights under this Agreement. 
 (e) If there has not been a Change in Control, the Reviewing Party shall be as determined by the Board of Directors, either in the specific case or under procedures adopted by the Board. If there
has been a Change in Control (other than one approved in advance by a majority of the company’s Board of Directors who were elected by the public shareholders prior to such Change in Control), the Reviewing Party shall be the Independent
Counsel referred to in Section 4. 
 (f) If there has been a Change in Control and any dispute arises under this
Agreement, the parties agree that at the Indemnitee’s option such dispute shall be resolved by binding arbitration proceedings in accordance with the rules of the American Arbitration Association and the results of such proceedings shall be
conclusive on both parties and shall not be subject to judicial interference or review on any ground whatsoever, including without limitation any claim that the Company was wrongfully induced to enter into this agreement to arbitrate such a dispute.
The Company shall pay the cost of any arbitration proceedings under this Agreement. The Indemnitee shall be entitled to advancement of his Expenses in connection with such proceedings and, notwithstanding anything to the contrary in
subsection (c) above, the Indemnitee shall be obligated to reimburse the Company for his Expenses in connection with such arbitration proceedings only if it is finally and specifically determined by the arbitrators that the Indemnitee’s
position in initiating the arbitration was frivolous and completely without merit. 
  

 5 

 4. Independent Counsel. 
 (a) The Company agrees that if there is a Change in Control of the Company (other than a Change of Control which has been approved in advance by a majority of the Company’s Board of
Directors who were elected by the public shareholders prior to such Change in Control) then with respect to all matters thereafter arising concerning the rights of the Indemnitee to indemnity payments and Expense Advances under the Charter, this
Agreement or any other agreement or Company by-law now or hereafter in effect relating to indemnification, the Company shall (unless otherwise agreed by the Indemnitee) seek legal advice exclusively from Independent Counsel selected by the
Indemnitee and approved by the Company (which approval shall not be unreasonably withheld). Such counsel, among other things, shall render its written opinion to the Company and to the Indemnitee as to whether the Indemnitee is entitled to be
indemnified under this Agreement. The Company agrees to pay the reasonable fees and expenses of the Independent Counsel and fully to indemnify such counsel against any and all expenses (including attorney’s fees), claims, liabilities and
damages arising out of or relating to this Agreement or such counsel’s engagement pursuant hereto. 
 (b) Following the
initial selection of Independent Counsel by the Indemnitee the Company may within seven (7) days deliver to the Indemnitee a written objection to such selection. Such objection may be asserted only on the ground that the Independent Counsel
selected does not satisfy the definition of Independent Counsel in subsection 1(c) and the objection shall set forth with particularity the factual basis for such assertion. Absent a proper and timely objection, the person, persons or firm
selected shall act as Independent Counsel. If such written objection is made, the Indemnitee may select alternate Independent Counsel. If the Company objects to the alternate selection the Indemnitee may either seek a judicial determination that
such objections were inappropriate or else the Indemnitee may direct that the Company select Independent Counsel by lot from among the North Carolina firms having more than 25 attorneys and having a rating of “av” or better in the then
current Martindale-Hubbell Law Directory. Such selection by lot shall be made by the principal financial officer of the Company in the presence of the Indemnitee (and the Indemnitee’s legal counsel, or either or neither of them as the
Indemnitee may elect). Such law firms shall be contacted in the order of their selection, requesting each firm to accept engagement to make the determination required, until one of such firms accepts such engagement. Notwithstanding the foregoing,
in lieu of selection of alternate Independent Counsel after the Company has objected to the Indemnitee’s first or second selection, the Indemnitee may request and direct that the Independent Counsel method be dispensed with and that any dispute
be decided by arbitration as provided in subsection 3(f). 
 (c) Considering that a fundamental purpose of this
Agreement is to provide for and ensure the timely advance of an Indemnitee’s Expenses in any event, if there is a Change of Control and the Indemnitee must commence arbitration proceedings to secure an advance of 

  

 6 

 
his Expenses, the arbitrators shall have discretion to award punitive damages to the Indemnitee if it is found that the Company’s failure to advance the
Indemnitee’s expenses makes such an award appropriate in the circumstances. 
 5. Indemnification for Enforcement
Expenses. The Company shall indemnify the Indemnitee against any and all Expenses (including attorneys’ fees) and, if requested by the Indemnitee, shall (within two business days of such request) advance such expenses to the Indemnitee,
which are incurred by the Indemnitee in connection with any Proceeding initiated by the Indemnitee for: (i) indemnification or advancement of Expenses by the Company under the North Carolina Business Corporation Act (the “NCBCA”), the
Charter, this Agreement, or any other agreement or Company by-law, vote of shareholders or resolution of the Board now or hereafter in effect relating to indemnification; or (ii) recovery under any directors’ and officers’ liability
insurance policies maintained by the Company. The Indemnitee shall cooperate with the person, persons or entity making the determination with respect to the Indemnitee’s entitlement to indemnification under this Agreement. Any expenses incurred
by the Indemnitee in so cooperating shall be borne by the Company (irrespective of the determination as to the Indemnitee’s entitlement to indemnification) and the Company hereby indemnifies and agrees to hold the Indemnitee harmless therefrom.

 6. Success; Partial Indemnity, etc. Notwithstanding any other provision of this Agreement, to the extent that the
Indemnitee has been successful on the merits or otherwise in defense of any or all claims made against him in a Proceeding or in defense of any issue or matter therein, including dismissal without prejudice, the Indemnitee shall be indemnified
against all Expenses incurred in connection therewith. If the Indemnitee is entitled under any provision of this Agreement to indemnification by the Company for some or a portion of the Expenses, judgments, settlements, penalties or fines paid as a
result of a Proceeding but not, however, for all of the total amount thereof, the Company shall nevertheless indemnify the Indemnitee for the portion thereof to which the Indemnitee is entitled. 
 7. Burden of Proof. In connection with any determination by the Reviewing Party or otherwise as to whether the Indemnitee is
entitled to be indemnified hereunder, the person or persons or entity or body making such determination shall presume that the Indemnitee is entitled to indemnification under this Agreement and the burden of overcoming such presumption by clear and
convincing evidence shall be on the Company. The termination of any claim, action, suit or proceeding by judgment, order, settlement (whether with or without court approval) or conviction, or upon a plea of nolo contendere, or its equivalent,
shall not create a presumption that the Indemnitee’s activities were at the time taken known or believed by him to be clearly in conflict with the best interests of the Company, or that a court has determined that indemnification is not
permitted. In addition, neither the failure of the Reviewing Party to have made a determination as to the Indemnitee’s state of mind, nor an actual determination by the Reviewing Party that the Indemnitee had a state of mind prior to the
commencement of arbitration (if applicable) or legal proceedings to secure a determination that the Indemnitee should be indemnified under this agreement and applicable law, shall be a defense to the Indemnitee’s claim or create a presumption
of any kind. The knowledge and/or actions, or failure to act, of any director, officer, agent, fiduciary or employee of the Company shall not be imputed to the Indemnitee for purposes of determining the right to indemnification under this Agreement.

  

 7 

 8. Nonexclusivity, Etc. The rights of the Indemnitee hereunder shall be in
addition to any other rights the Indemnitee may have under the Charter, the North Carolina Business Corporation Act (the “NCBCA”), any by-law of the Company, any other agreement, a vote of shareholders or a resolution of the Board of
Directors or otherwise. To the extent that a change in the NCBCA (whether by statute or judicial decision) permits greater indemnification by agreement than would be afforded currently under the Charter and this Agreement, it is the intent of the
parties that the Indemnitee shall enjoy by this Agreement the greater benefits so afforded by such change. 
 9.
Contribution. In the event the indemnification provided for in Section 3 of this Agreement is unavailable to the Indemnitee in connection with any Proceeding under any Federal law, the Company, in lieu of indemnifying the Indemnitee,
shall contribute to the Expenses incurred by the Indemnitee in such proportion as deemed fair and reasonable by the Reviewing Party, in light of all the circumstances of the Proceeding giving rise to such Expenses, in order to reflect (i) the
relative benefits received by the Company and the Indemnitee as a result of the event(s) and/or transaction(s) giving rise to such Proceeding, and (ii) the relative fault of each. 
 10. Liability Insurance. To the extent the Company maintains an insurance policy or policies providing directors’ and
officers’ liability insurance, the Indemnitee shall be covered by such policy or policies, in accordance with its or their terms, to the maximum extent of the coverage available for any Company director or officer. 
 11. Period of Limitations. No legal action shall be brought and no cause of action shall be asserted by or in the right of the
Company against the Indemnitee, the Indemnitee’s spouse, heirs, executors or personal or legal representatives after the expiration of two years from the date of accrual of such cause of action, and any claim or cause of action of the Company
shall be extinguished and deemed released unless asserted by the timely filing of a legal action within such two-year period; provided, however, that if any shorter period of limitations is otherwise applicable to any such cause of action such
shorter period shall govern. 
 12. Procedures Valid. The Company shall be precluded from asserting in any judicial
proceeding or arbitration commenced pursuant to this Agreement that the procedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate in any such court or before any such arbitrator that the Company is
bound by all the provisions of this Agreement. If a determination is made that the Indemnitee is entitled to indemnification, the Company shall be bound by such determination in any judicial proceeding or arbitration. 
 13. Amendments, Etc. No supplement, modification or amendment of this Agreement shall be binding unless executed in writing by
both of the parties hereto. No 

  

 8 

 
waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any other provisions hereof (whether or not similar) nor
shall such waiver constitute a continuing waiver. 
 14. Subrogation. In the event of payment under this Agreement,
the Company shall be subrogated to the extent of such payment to all of the rights of recovery of the Indemnitee, who shall execute an appropriate document in favor of the Company to secure such rights. 
 15. No Duplication of Payments. The Company shall not be liable under this Agreement to make any payment in connection with any
Proceeding to the extent the Indemnitee has otherwise actually received payment (under any insurance policy, the Charter, Company by-laws or otherwise) of the amounts otherwise indemnifiable hereunder. 
 16. Binding Effect, Etc. This Agreement shall be binding upon and inure to the benefit of and be enforceable by the parties hereto
and their respective successors, assigns (including any direct or indirect successor by purchase, merger or consolidation or otherwise to all or substantially all of the business and/or assets of the Company), spouses, heirs, executors and personal
and legal representatives. This Agreement shall continue in effect regardless of whether Indemnitee continues to serve as a director or corporate officer of the Company or of any other entity at the Company’s request. In the event of his
demise, this agreement shall be enforceable by the Indemnitee’s legal representatives as fully as if the Indemnitee had survived. 
 17. Severability; Headings; Pronouns. The provisions of this Agreement shall be severable in the event that any of the provisions hereof (including any provision within a single section, paragraph or sentence)
is held by a court of competent jurisdiction to be invalid, void or otherwise unenforceable in any respect, and the validity and enforceability of any such provision in every other respect and of the remaining provisions hereof shall not be in any
way impaired and shall remain enforceable to the fullest extent permitted by law. The headings of the Sections of this Agreement are inserted for convenience only and shall not be deemed to constitute part of this Agreement or to affect the
construction thereof. The masculine pronoun wherever used in this Agreement includes the corresponding feminine pronoun. 
 18. Notice of Proceedings; Notices. The Indemnitee agrees promptly to notify the Company in writing upon being served with any summons, citation, subpoena, complaint, indictment, information or other document relating to any
Proceeding or matter which may be subject to indemnification or advancement of Expenses covered hereunder. All notices, requests, demands and other communications hereunder shall be in writing and shall be deemed to have been duly given
(i) upon delivery if delivered by hand and receipted for by the party to whom said notice or other communication shall have been directed, or (ii) on the third business day after mailing if mailed by certified or registered mail with
postage prepaid, and addressed as follows: If to the Indemnitee, as shown after the Indemnitee’s signature below; and if to the Company, to Corporate Secretary, Rayonier Inc., 50 N. Laura Street, Suite 1900, Jacksonville, FL 32202 or such other
address as may have been furnished in writing to the Indemnitee by the Company or to the Company by the Indemnitee, as the case may be. 
  

 9 

 19. Governing Law. This Agreement shall be governed by and construed and enforced in accordance
with the laws of the State of North Carolina applicable to contracts made and to be performed in such state without giving effect to the principles of conflicts of laws. 
 IN WITNESS WHEREOF, the parties hereto have executed this Agreement to be effective as of the day and year first above written. 
  

			
	RAYONIER INC.
		
	By:	 	  

		 	W. L. Nutter
		 	Chairman, President and
		 	Chief Executive Officer
		
		 	  

		 	[Indemnitee]

  

 10

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