Document:

Amendment No. 1 to Lease and License Agreement, dated 05/28/2004

 Exhibit 10.16 

MARYLAND TECHNOLOGY DEVELOPMENT CENTER 

LICENSE AGREEMENT 

AMENDMENT 1 

This addendum is made this
28th day of May, 2004, by and between MEDCO and Neogenix
Oncology, Inc. (“Licensee”). 
 WHEREAS, MEDCO and Licensee have entered into a License Agreement dated April 28,
2004; 
 WHEREAS, Licensee currently occupies office #317 in the Maryland Technology Development Center in Montgomery County,
Maryland (the “Original Premises”); 
 WHEREAS Licensee wishes to expand into additional space within the Maryland
Technology Development Center and MEDCO is willing to provide for such expansion based on the terms provided for below; 
 NOW,
THEREFORE, in consideration of the mutual covenants and agreements stated herein, the parties agree as follows: 
  

	 	1.	Effective June 1, 2004, Licensee shall occupy Lab #222 (the “Expansion Premises”). 

 

	 	2.	The termination date of this License for the Expansion Premises shall be April 30, 2005, to coincide with the termination date for Licensee’s Original
Premises. 

  

	 	3.	The additional cash license payment resulting from the Expansion Premises (the “Monthly Payment”) shall be payable by Licensee in equal monthly installments,
on or before the first day of each month, and shall be as follows: 

  

				
	 6/1/04 to 4/30/05
	  	$	3,000
	 5/1/05 to 4/30/06
	  	$	3,300
	 5/1/06 to 4/30/07
	  	$	3,630

  

	 	4.	The aggregate Monthly Payment, to include the Monthly Payment for the Original Premises and the Expansion Premises provided for herein shall be as follows:

  

				
	 6/1/04 to 4/30/05
	  	$	481 + $3,000 = $3,481
	 5/1/05 to 4/30/06
	  	$	529 + $3,300 = $3,829
	 5/1/06 to 4/30/07
	  	$	582 + $3,630 = $4,212

	 	5.	Any Renewal Term provided under the License Agreement shall now be applicable to all space occupied by Licensee, including the Original Premises and the Expansion
Premises provided for herein. 

  

	 	6.	On or before the Effective Date of this Amendment, Licensee shall pay to MEDCO a sum equal to one (1) Monthly Payment for the Expansion Premises, to be held by
MEDCO as security deposit for the full, faithful and punctual performance by Licensee's terms, covenants and conditions contained herein for the full term of the License Agreement. At such time that this License Amendment commences, Licensee shall
be required to pay a sum of $3,000.00 as security deposit. 

  

	 	7.	All other provisions of the original License Agreement shall apply to this Amendment. 

This Amendment may be signed in counterparts. 
  

									
	FOR:	 	 Maryland Economic
 Development
Corporation
	  		 	FOR:	 	 Licensee
 Neogenix Oncology,
Inc.

					
	BY:	 	
 

	  		 	BY:	 	
 

		 	Scheer Partners Management, Inc. MTDC Manager	  		 		 	Director, R&D
					
	Date:	 	5/27/04	  		 	Date:	 	May 28, 2004
					
	BY:	 	 /s/ Hans Mayer
	  		 		 	
		 	 Hans Mayer
 Executive
Director, MEDCO
	  		 		 	
					
	Date:	 	Jun 7 2004	  		 		 	

  

 2Amendment No. 2 to Lease and License Agreement, dated 06/17/2005

 Exhibit 10.17 

MARYLAND TECHNOLOGY DEVELOPMENT CENTER 

LICENSE AGREEMENT 

AMENDMENT 2 

This addendum is made this
17th day of June, 2005, by and between MEDCO and Neogenix
Oncology, Inc. (“Licensee”). 
 WHEREAS, MEDCO and Licensee have entered into a License Agreement dated April 28,
2004; Amendment 1 dated June 1, 2004; 
 WHEREAS, Licensee currently occupies office #317 in the Maryland Technology
Development Center in Montgomery County, Maryland (the “Original Premises”); 
 WHEREAS Licensee wishes to expand into
additional space within the Maryland Technology Development Center and MEDCO is willing to provide for such expansion based on the terms provided for below; 

NOW, THEREFORE, in consideration of the mutual covenants and agreements stated herein, the parties agree as follows: 

 

	 	1.	Effective July 1, 2005, Licensee shall occupy lab #211 (the “adjusted Premises”). 

 

	 	2.	Notwithstanding anything contained in the License Agreement to the contrary, effective May 1, 2005 (the “Effective Date”), the Term of the License
Agreement is herby extended for a period of One (1) year, commencing on May 1, 2005 and ending on April 30, 2006. 

  

	 	3.	The additional cash license payment resulting from the Expansion Premises (the “Monthly Payment”) shall be payable by Licensee in equal monthly installments,
on or before the first day of each month, and shall be as follows: 

  

				
	 7/1/05 to 4/30/06
	  	$	3,300
	 5/1/06 to 4/30/07
	  	$	3,630
	 5/1/07 to 4/30/08
	  	$	3,993

  

	 	4.	The aggregate Monthly Payment, to include the Monthly Payment for the Original Premises and the Expansion Premises provided for herein shall be as follows:

  

				
	 7/1/05 to 4/30/06
	  	$	3,829 + $3,300 = $7,129
	 5/1/06 to 4/30/07
	  	$	4,212 + $3,630 = $7,842
	 5/1/07 to 4/30/08
	  	$	4,633 + $3,993 = $8,626

	 	5.	Any Renewal Term provided under the License Agreement shall now be applicable to all space occupied by Licensee, including the Original Premises and the Expansion
Premises provided for herein. 

  

	 	6.	On or before the Effective Date of this Amendment, Licensee shall pay to MEDCO a sum equal to one (1) Monthly Payment for the Expansion Premises, to be held by
MEDCO as security deposit for the full, faithful and punctual performance by Licensee’s terms, covenants and conditions contained herein for the full term of the License Agreement. At such time that this License Amendment commences, Licensee
shall be required to pay a sum of $3,300.00 as security deposit. 

  

	 	7.	All other provisions of the original License Agreement shall apply to this Amendment. 

This Amendment may be signed in counterparts. 
  

									
	 FOR:
	 	Maryland Economic	 		 	FOR:	 	Licensee
		 	Development Corporation	 		 		 	Neogenix Oncology, Inc.
					
	 BY:
	 	
 

	 		 	BY:	 	
 

		 	 Scheer Partners Management, Inc.

MTDC Manager
	 		 		 	
					
	 Date:
	 	06/17/2005	 		 	Date:	 	June 17, 2005
					
	 BY:
	 	
 

	 		 		 	
		 	Executive Director, MEDCO	 		 		 	
					
	 Date:
	 	9/7/05Amendment No. 3 to Lease and License Agreement , dated 07/02/2006

 Exhibit 10.18 

MARYLAND TECHNOLOGY DEVELOPMENT CENTER 

LICENSE AGREEMENT 

AMENDMENT 3 
 This
addendum is made this          day of             , 2006, by and between MEDCO and Neogenix Oncology, Inc. (“Licensee”). 

WHEREAS, MEDCO and Licensee have entered into a License Agreement dated April 28, 2004; Amendment 1 dated June 1, 2004 and
Amendment #2 dated June 17, 2005; 
 WHEREAS, Licensee currently occupies office Labs #211 and #222, and office 317 in the
Maryland Technology Development Center in Montgomery County, Maryland (the “Original Premises”); 
 WHEREAS Licensee
wishes to extend its license agreement within the Maryland Technology Development Center and MEDCO is willing to provide for such expansion based on the terms provided for below; 

NOW, THEREFORE, in consideration of the mutual covenants and agreements stated herein, the parties agree as follows: 

 

	 	1.	Notwithstanding anything contained in the License Agreement to the contrary, effective May 1, 2006 (the “Effective Date”), the Term of the License
Agreement is herby extended for a period of One (1) year, commencing on May 1, 2006 and ending on April 30, 2007. 

  

	 	2.	The aggregate Monthly Payment, for all Premises currently occupied by licensee shall be as follows: 

 

			
	 5/1/06 to 4/30/07
	  	$4,212 + $3,630 = $7,842
	 5/1/07 to 4/30/08
	  	$4,633 + $3,993 = $8,626

  

	 	3.	All other provisions of the original License Agreement shall apply to this Amendment 

 This Amendment may be signed in counterparts. 

 

													
	FOR:	  	Maryland Economic	  		  	FOR:	  	Licensee
		  	Development Corporation	  		  		  	 Neogenix Oncology, Inc.
					
	BY:	  	
 

	  		  	BY:	  	
 

		  	Scheer Partners Management, Inc.	  		  		  	
		  	MTDC Manager	  		  		  	
					
	Date:	  	6/10/06	  		  	Date:	  	6-10-06
					
	BY:	  	 /s/ Robert C. Brennan
	  		  		  	
		  	Robert C. Brennan	  		  		  	
		  	Executive Director, MEDCO	  		  		  	
					
	Date:	  	7/2/06Amendment No. 4 to Lease and License Agreement , dated 05/11/2007

 Exhibit 10.19 

MARYLAND TECHNOLOGY DEVELOPMENT CENTER 

LICENSE AGREEMENT 

AMENDMENT 4 

This addendum is made this
11th day of May, 2007, by and between MEDCO and Neogenix
Oncology, Inc. (“Licensee”). 
 WHEREAS, MEDCO and Licensee have entered into a License Agreement dated April 28,
2004; Amendment 1 dated June 1, 2004, Amendment #2 dated June 17, 2005, and Amendment #3 dated June 14, 2006; 

WHEREAS, Licensee currently occupies Labs #211 and #222, and office #317 in the Maryland Technology Development Center in Montgomery
County, Maryland (the “Original Premises”); 
 WHEREAS Licensee wishes to extend its license agreement within the
Maryland Technology Development Center and MEDCO is willing to provide for such expansion based on the terms provided for below: 

NOW, THEREFORE, in consideration of the mutual covenants and agreements stated herein, the parties agree as follows: 

 

	 	1.	Notwithstanding anything contained in the License Agreement to the contrary, effective May 1, 2007 (the “Effective Date”), the Term of the License
Agreement is herby extended for a period of One (1) year, commencing on May 1, 2007 and ending on April 30, 2008. 

  

	 	2.	The aggregate Monthly Payment, for all Premises currently occupied by licensee shall be as follows: 

 

				
	 5/1/07 to 4/30/08
	  	$	8,626
	 5/1/08 to 4/30/09
	  	$	9,489

  

	 	3.	All other provisions of the original License Agreement shall apply to this Amendment 

 This Amendment may be signed in counterparts. 

 

													
	FOR:	  	Maryland Economic	  		  	FOR:	  	Licensee
		  	Development Corporation	  		  		  	 Neogenix Oncology, Inc.
					
	BY:	  	
 

	  		  	BY:	  	
 

		  	Scheer Partners Management, Inc.	  		  		  	
		  	MTDC Manager	  		  		  	
					
	Date:	  	05/14/07	  		  	Date:	  	May 11, 2007
					
	BY:	  	 /s/ Robert C. Brennan
	  		  		  	
		  	Robert C. Brennan	  		  		  	
		  	Executive Director, MEDCO	  		  		  	
					
	Date:	  	6/25/07

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