Document:

CONSULTING AGREEMENT WITH STACK PHARMACEUTICALS, INC

 Exhibit 10.42 
 ELIXIR PHARMACEUTICALS, INC. 
 CONSULTING AGREEMENT 
 THIS CONSULTING AGREEMENT (“Agreement”) effective October 20, 2006 (the “Effective Date”) is made between Elixir
Pharmaceuticals, Inc. (the “Company”), with an office at 12 Emily Street, Cambridge, MA 02139 and Stack Pharmaceuticals, Inc. (the “Consultant”), with an office at 5 Sylvan Way, Parsippany, NJ 07054 for the purpose of setting
forth the exclusive terms and conditions by which Company desires to acquire Consultant’s services on a temporary basis. 
 This
agreement supersedes the existing Consulting Agreement between the parties dated September 1, 2005. 
 In consideration of the mutual
obligations specified in this Agreement, the parties, intending to be legally bound hereby, agree to the following: 
 1. Services:

 (a) Company hereby retains Consultant, and Consultant hereby agrees to perform for Company, certain services (the
“Services”) assigned to Consultant by the Company in the Company’s sole discretion, initially including but not limited to the field of metabolic disease (the “Field”). These Services are to be performed by Consultant only
at the specific request of Company and are subject to the limits specified. Consultant is responsible for providing the necessary equipment, tools, materials and supplies to perform the Services. 
 (b) Consultant agrees to keep Company updated, promptly upon Company’s request, of any progress, problems, and/or developments of which Consultant
is aware regarding the Services. Company shall have the right to require such updates in writing from Consultant in a format specified by Company or acceptable to Company in its sole discretion. 
 2. Compensation: 
 (a) In
exchange for the full, prompt and satisfactory performance of all Services to be rendered to Company hereunder, Company shall provide Consultant, as full and complete compensation for the Services rendered hereunder: 
 $2,500 per day plus reasonable out-of-pocket expenses for a minimum of eight (8) days per month for twelve (12) months subject to termination by
either party upon sixty (60) days notice. Company shall pay such compensation and expenses within thirty (30) days of receipt of a monthly invoice from Consultant setting forth the Services performed (but Consultant will not submit
invoices more often than monthly) and upon approval of such invoice by Company; and 

 (b) Consultant shall not be entitled to receive any other compensation or any benefits from Company.
Except as otherwise required by law, Company shall not withhold any sums or payments made to Consultant for social security or other federal, state or local tax liabilities or contributions, and all withholdings, liabilities, and contributions shall
be solely Consultant’s responsibility. Company shall issue a Form 1099 to Consultant at the appropriate time. Further, Consultant understands and agrees that the Services are not covered under the unemployment compensation laws and are not
intended to be covered by workers’ compensation laws. 
 3. Nondisclosure: 
 (a) Consultant understands that, in connection with his engagement with Company, he may receive, produce, or otherwise be exposed to Company’s trade
secrets, business, proprietary and/or technical information, including, without limitation, business plans or projections, hardware and software designs or engineering techniques, software including listings, source code, screen formats and flow
charts, inventions (whether patentable or not), know-how, show-how, research plans and projects, pricing policies, cost information, supplier and customer lists and contracts, manufacturing techniques, applications and service policies, financial
and sales performance data, personnel information, and all derivatives, improvements and enhancements to any of the above (including those derivatives, improvements and enhancements that were created or developed by Consultant under this Agreement),
in addition to all information Company receives from others under an obligation of confidentiality (individually and collectively “Confidential Information”). Confidential Information shall also include all other information considered to
be confidential by the Company and all information which has not been made public. 
 (b) Consultant acknowledges that the Confidential
Information is the sole, exclusive and extremely valuable property of Company. Accordingly, Consultant agrees to segregate all Confidential Information from information of other companies and agrees not to reproduce any Confidential Information
without Company’s prior written consent, not to use the Confidential Information except in the performance of this Agreement, and not to divulge all or any part of the Confidential Information in any form to any third party, either during or
after the term of this Agreement. Upon termination or expiration of this Agreement for any reason, Consultant agrees to cease using and to return to Company all whole and partial copies and derivatives of the Confidential Information, whether in
Consultant’s possession or under Consultant’s direct or indirect control. 
 (c) Consultant shall not disclose or otherwise make
available to Company in any manner any confidential and proprietary information received by Consultant from third parties. Consultant warrants that his/her performance of all the terms of this Agreement does not and will not breach any agreement
entered into by Consultant with any other party, and Consultant agrees, not to enter into any agreement, oral or written, in conflict herewith. In addition, Consultant recognizes that the Company has received and in the future will receive from
third parties their confidential or proprietary information subject to a duty on the Company’s part to maintain the confidentiality of such information and to use such information only for certain limited purposes. The Consultant agrees that
he/she owes the Company and such third parties, during the term of the Consultant’s relationship with the Company and thereafter, regardless for the reason for the 

  

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termination of the relationship, a duty to hold all such confidential or proprietary information in the strictest of confidence and not to disclose such
information to any person, firm or corporation (except as necessary in carrying out his/her work for the Company consistent with the Company’s agreement with such third party) or to use such information for the benefit of anyone other than for
the Company or such third party (consistent with the Company’s agreement with such third party). 
 4. Ownership of Work
Product: 
 (a) Consultant agrees to promptly disclose to Company any and all Work Product. “Work Product” includes without
limitation any and all notes, drawings, designs, technical data, know how, works of authorship, firmware, software, ideas, improvements, inventions, material, information, work or product conceived, created, written or first reduced to practice by
Consultant or jointly with others in the performance of the Services under this Agreement and/or resulting from use of Confidential Information Consultant agrees to assign and does hereby assign to Company all right, title and interest, including
without limitation any copyright, mask work, patent, trade secret, trademark (including the good will associated therewith) or other intellectual property rights in and to the Work Product. All works of authorship, firmware, software or other
applicable Work Product shall be considered works for hire by Consultant for Company and all Work Product shall be the sole and exclusive property of Company. Upon expiration or termination for any reason of this Agreement, Consultant agrees to and
shall provide Company with all Work Product generated under this Agreement. 
 (b) Consultant hereby grants to Company under any and all
intellectual property rights a non-exclusive, irrevocable, royalty free, and worldwide license to use all notes, works of authorship, ideas, designs, firmware, software, technical data, research, reports, and other such inventions not first
developed by Consultant in the course of or resulting from the Services, but that are incorporated in any Work Product delivered by Consultant under this Agreement (“Background Material”) including, without limitation, the right to make,
have made, sell, offer for sale, rent, lease, import, copy, create derivative works, display, perform, and distribute the Background Material. 
 (c) Consultant further agrees at the request and cost of the Company: 
 (i) to apply for, obtain, register and vest in the name of
the Company alone (unless the Company otherwise directs) patents, copyrights, mask works, trademarks or other analogous protection in any country throughout the world and when so obtained or vested to renew and restore the same, and 
 (ii) to defend any judicial, opposition or other proceedings in respect of such applications and any judicial, opposition or other proceedings or
petitions or applications for revocation of such patent, copyright, mask work, trademark or other analogous protection. 
  

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 (d) Consultant also agrees, at the request and cost of Company, to promptly sign, execute, make and do
all such deeds, documents, acts and things as Company may reasonably require or desire to perfect Company’s entire right, title, and interest in and to any Work Product and/or Background Material. Consultant agrees that if Company is unable
because of Consultant’s unavailability, dissolution, or for any other reason, to secure the signature of an authorized agent of Consultant to apply for or to pursue any application for any United States or foreign patents, mask work, copyright
or trademark registrations covering the assignments to Company above, then Consultant hereby irrevocably designates and appoints Company and its duly authorized officers and agents as Consultant’s agent and attorney in fact, to act for and in
Consultant’s behalf and stead to execute and file any such applications and to do all other lawfully permitted acts to further the prosecution and issuance of patents, copyright, mask work and trademark registrations thereon with the same legal
force and effect as if executed by an authorized agent of Consultant. 
 (e) Consultant warrants that he has good and marketable title to the
Background Material and Work Product and that he shall not knowingly incorporate into any Work Product any material that would infringe any copyright, trade secret, trademark or other intellectual property rights of any person or entity. Consultant
further warrants that the Background Material and Work Product shall be free and clear of all liens, claims, encumbrances or demands of third parties, including any claims by any such third parties of any right, title or interest in or to the
Background Material and/or Work Product arising out of any patent, trade secret, copyright or other intellectual property right. Consultant shall indemnify, defend and hold harmless the Company and its customers from any and all liability, loss,
cost, damage, judgment or expense (including reasonable attorney’s fees) resulting from or arising in any way out of any such claims by any third parties, and/or which are based upon, or are the result of any breach of, the warranties contained
in this Section 4. In the event of a breach of the warranties set forth in this Section 4, in addition to all other remedies available to Company, Consultant shall, at no additional cost to Company, replace or modify the Work Product
within a reasonable time, with a functionally equivalent and conforming Work Product at his own expense, or obtain for Company the right to continue using the Work Product and in all other respects use his best efforts to remedy the breach.

 5. Indemnification/Release: 
 (a) Consultant agrees to take all necessary precautions to prevent injury to any persons (including employees of Company) or damage to property (including Company’s property) during the term of this Agreement,
and shall indemnify, defend and hold harmless Company, its officers, directors, shareholders, employees, representatives and/or agents from any claim, liability, loss, cost, damage, judgment, settlement or expense (including reasonable
attorney’s fees) resulting from or arising in any way out of injury (including death) to any to person or damage to property arising in any way out of any act, error, omission or negligence on the part of Consultant in the performance or
failure to fulfill any Services or obligations under this Agreement. 
 (b) Consultant further agrees that any breach of Sections 3, 4 or 6
hereof by Consultant will cause irreparable harm to Company and that in the event of such breach or threatened breach, Company shall have, in addition to any and all remedies of law and those remedies stated in this Agreement, the right to an
injunction, specific performance or other equitable relief to prevent the violation of Consultant’s obligations hereunder. 
  

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 6. Termination: This Agreement shall commence on the Effective Date and shall continue
until terminated by either party upon sixty (60) days written notice. In the event of termination, Consultant shall, upon request, perform such work as may be requested to transfer work in process to the Company or to a party designated by the
Company. The parties further agree that any termination of this Agreement will not release nor discharge Consultant from his or her obligations as specified in Sections 3, 4, 5, 6, 7, 8 or 9. 
 7. Independent Contractor: 
 (a) Company and Consultant expressly agree and understand that Consultant is an independent contractor and nothing in this Agreement nor the services rendered hereunder is meant, or shall be construed in any way or manner, to create between
them a relationship of employer and employee, principal and agent, partners or any other relationship other than that of independent parties contracting with each other solely for the purpose of carrying out the provisions of the Agreement.
Accordingly, Consultant acknowledges and agrees that Consultant shall not be entitled to any benefits provided by the Company to its employees. In addition, Consultant shall have sole and exclusive responsibility for the payment of all federal,
state and local income taxes, for all employment and disability insurance and for Social Security and other similar taxes with respect to any compensation provided by the Company hereunder. Consultant shall assume and accept all responsibilities
which are imposed on independent Consultants by any statute, regulation, rule of law, or otherwise. Consultant is not the agent of Company and is not authorized and shall not have the power or authority to bind Company or incur any liability or
obligation, or act on behalf of Company. At no time shall Consultant represent that he is an agent of the Company, or that any of the views, advice, statements and/or information that may be provided while performing the Services are those of the
Company. 
 (b) While Company is entitled to provide Consultant with general guidance to assist Consultant in completing the scope of work to
Company’s satisfaction, Consultant is ultimately responsible for directing and controlling the performance of the task and the scope of work, in accordance with the terms and conditions of this Agreement. Consultant shall use his best efforts,
energy and skill in his own name and in such manner as he sees fit. 
 8. Restriction on Solicitation: 
 This section 8.0 will not pertain to Consultants introduced to the Company by SPI. 
 (a) During the term of this Agreement and for a period of one (1) year commencing on the expiration of this Agreement, Consultant shall not, directly
or indirectly, alone or as a partner, joint venturer, consultant, Consultant, lender, officer, director, employee, stockholder or investor of any entity, employ or knowingly permit any company or business organization directly or indirectly
controlled by Consultant to employ any person who is or was an employee, agent, representative or consultant of the Company at any time during the term of this Agreement or during the period of one year prior to or thereafter, or in any manner seek
to solicit or induce any such person to leave his or her employment with the Company or assist in the recruitment or hiring of any such person, except as otherwise agreed to by the parties hereto. 
  

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 (b) Since a breach of the provisions of this Section 8 could not adequately be compensated by money
damages, the Company shall be entitled, in addition to any other right and remedy available to it, to an injunction restraining such breach or a threatened breach, and in either case no bond or other security shall be required in connection
therewith. Consultant agrees that the provisions of this Section 8 are necessary and reasonable to protect the Company in the conduct of its business. If any restriction contained in this Section 8 shall be deemed to be invalid, illegal,
or unenforceable by reason of the extent, duration, or geographical scope thereof, or otherwise, then the court making such determination shall have the right to reduce such extent, duration, geographical scope, or other provisions hereof, and in
its reduced form such restriction shall then be enforceable in the manner contemplated hereby. 
 9. General: 
 (a) This Agreement does not create an obligation on Company to continue to retain Consultant beyond its term. This Agreement may not be changed unless
mutually agreed upon in writing by both Consultant and Company Sections 3, 4, 5, 6, 7, 8 and 9 shall survive the termination of this Agreement regardless of the manner of such termination. Any waiver by Company of a breach of any provision of this
Agreement shall not operate or be construed as a waiver of any subsequent breach of such provision or any other provision hereof. 
 (b)
Consultant hereby agrees that each provision herein shall be treated as a separate and independent clause, and the urtenforceability of any one clause shall in no way impair the enforceability of any of the other clauses herein. Moreover, if one or
more of the provisions contained in this Agreement shall for any reason be held to be excessively broad as to scope, activity, subject or otherwise so as to be unenforceable at law, such provision or provisions shall be construed by the appropriate
judicial body by limiting or reducing it or them, so as to be enforceable to the maximum extent compatible with the applicable law as it shall then appear. 
 (c) Company shall have the right to assign this Agreement to its successors and assigns and this Agreement shall inure to the benefit of and be enforceable by said successors or assigns. Consultant may not assign this
Agreement or any rights or obligations here under without the prior written consent of Company and this Agreement shall be binding upon Consultant’s heirs, executors, administrators and legal representatives. This Agreement and all aspects of
the relationship between the parties hereto shall be construed and enforced in accordance with and governed by the internal laws of the Commonwealth of Massachusetts without regard to its conflict of laws provisions. 
 (d) This Agreement contains the entire agreement between the parties hereto with respect to the transactions contemplated herein. All other negotiations
and agreements (written or oral) between the parties are superseded by this Agreement and there are no representations, warranties, understandings or agreements other than those expressly set forth herein. The language of all parts of this Agreement
will in all cases be construed as a whole in accordance with its fair meaning and not strictly for or against either party hereto. 
  

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 (e) All notices provided for in this Agreement shall be given in writing and shall be effective when
either served by hand delivery, electronic facsimile transmission, express overnight courier service, or by registered or certified mail, return receipt requested, addressed to the parties at their respective addresses as set forth at the beginning
of this Agreement, or to such other address or addresses as either party may later specify by written notice to the other. 
 IN WITNESS
WHEREOF, the parties hereto have executed this Independent Consultant Agreement. 
  

									
	STACK PHARMACEUTICALS, INC.:	 		 	ELIXIR PHARMACEUTICALS, INC.
				
	Signature	 		 	By: 	 	Alan D. Watson, Ph.D.
			
	/s/ David Stack	 		 	/s/ Alan D. Watson
				
	Managing Partner	 		 	Title: 	 	Chief Business Officer
					
	Date 	 	10/30/06	 		 	Date 	 	10/26/06

 Please note one additional comment to Section 8, page 5. 
  

 7SERVICES AGREEMENT WITH MPM ASSET MANAGEMENT, LLC AND MCDONALD

 Exhibit 10.43 
 SERVICES AGREEMENT 
 SERVICES AGREEMENT effective as of March 1, 2007 among Elixir
Pharmaceuticals, Inc. (the “Company”), MPM Asset Management, LLC (“MPM”), and John McDonald (“Contractor”). 
 Recitals: 
 WHEREAS, the Company would like the Contractor to perform certain professional
services for it; 
 WHEREAS, the Contractor is an employee of MPM; and 
 WHEREAS, MPM would like the Contractor to perform the services for the Company;. 
 NOW, THEREFORE, in consideration of the premises and covenants set forth herein, the parties hereto, intending to be legally bound, do hereby agree as
follows: 
 1. Engagement. The Company hereby engages MPM to provide the services set forth in Section 2 hereof to the
Company, and MPM hereby accepts such engagement, on the terms and conditions set forth in this Agreement. 
 2. Services. MPM
(and specifically Contractor) will provide the services set forth on Exhibit A hereto (collectively, the “Services”). During the term of this Agreement, MPM will use commercially reasonable efforts to cause Contractor to
perform the Services. Contractor shall devote at least that portion of his business time to the performance of the Services hereunder as specified on Exhibit A. Contractor shall render the Services in a manner that is consistent with the
instructions of William Heiden of the Company; provided that MPM shall at all times have the sole right to control the manner of the performance of the Services rendered by Contractor hereunder. 
 3. Term. The term of MPM’s and Contractor’s engagement hereunder shall be deemed to have commenced on March 1, 2007, and
shall continue (unless sooner terminated in accordance with Section 5) until either party gives to the other party at least 30 days’ prior written notice of the notifying party’s determination to terminate this Agreement, which notice
shall specify the date of termination. 
 4. Compensation. 
 (a) Services Fee. In consideration of the Services to be performed hereunder, MPM shall be paid a services fee (the
“Services Fee”) at the rate of $11,000 per month, payable monthly in arrears, beginning with the payment for the month of March 1, 2007. The Services Fee may be further adjusted from time to time by the written agreement of the
Company and MPM, including without limitation as additional personnel and services are utilized from MPM. As additional consideration for the successful achievement of goals associated with providing the Services, MPM and Contractor shall be paid
additional consideration as described in Exhibit B (“Additional Consideration”). 

 (b) Reimbursement of Expenses. The Company shall reimburse MPM for an
amount equal to the expenses, consistent with MPM’s expense reimbursement policies, that are incurred in the performance of the Services by the Contractor. 
 (c) Entire Compensation. Notwithstanding anything to the contrary set forth herein, the compensation provided for in this
Section 4 shall constitute full payment for the Services to be rendered by MPM and Contractor to the Company. The Company shall have no obligation to pay any compensation to Contractor, who shall receive all of his compensation from MPM
pursuant to his employment relationship with MPM. 
 5. Termination. 
 (a) Termination. Each of the Company, MPM and Contractor may terminate this Agreement for any reason or for no reason upon
30 days prior written notice to the other party. 
 (b) Obligations upon Termination. In the event that the
Company shall terminate this Agreement, the Company shall not have any further obligation or liability under this Agreement, except for the payment of any Services Fees and/or Additional Consideration accrued and any reimbursable expenses incurred
by Contractor prior to termination. Upon any termination of this Agreement, Contractor shall immediately tender his written resignation from any office of the Company then held. 
 6. Non-Disclosure Agreements. Contractor has executed a Non-Disclosure, Inventions and Non-Solicitation Agreement with MPM (the
“Confidentiality Agreement”) that MPM and Contractor believe protects the disclosure of confidential information of the Company. Contractor shall abide by the terms of the Confidentiality Agreement as it relates to confidential or
proprietary information of the Company (including, without limitation, confidential or proprietary information of third parties that the Company is obligated to protect). MPM shall take all commercially reasonable actions necessary to ensure that
each of its other employees, agents or affiliates who may perform the Services for or on behalf of the Company or may have any access to the Company’s confidential or proprietary information pursuant to this Agreement signs a Non-Disclosure,
Inventions and Non-Solicitation Agreement substantially similar to the Confidentiality Agreement executed by Contractor. 
 7.
Representations and Warranties. 
 (a) Representations of the Company. As an inducement to MPM and
Contractor to enter into this Agreement, the Company represents and warrants to MPM and Contractor as follows: 
 (i)
The Company is duly organized and validly existing under the laws of the State of Delaware and has all requisite corporate power to enter into this Agreement. 

 (ii) Neither the execution and delivery of this Agreement nor the consummation of
the transactions contemplated herein nor compliance by the Company with any of the provisions hereof will: (a) violate any order, writ, injunction, decree, law, statute, rule or regulation applicable to it or (b) require the consent,
approval, permission or other authorization of, or qualification or filing with or notice to, any court, arbitrator or other tribunal or any governmental, administrative, regulatory or self-regulatory agency or any other third party. 
 (iii) This Agreement has been duly executed and delivered by the Company and constitutes a valid and binding agreement of the
Company, enforceable against the Company in accordance with its terms. 
 (b) Representations of Contractor. As an
inducement to the Company to enter into this Agreement, Contractor represents and warrants to the Company that Contractor is not a party to or otherwise subject to any agreements or restrictions that would prohibit Contractor from entering into this
Agreement and carrying out the transactions contemplated by this Agreement in accordance with the terms hereof, and this Agreement and the transactions contemplated hereby will not infringe or conflict with, and are not inconsistent with, the rights
of any other person or entity. The parties to this Agreement acknowledge that Contractor’s services are provided in connection with Contractor’s employment relationship with MPM. 
 8. Survival of Representations, Warranties and Covenants. The provisions of Sections 5.6(b) and 6 hereof shall survive the termination of
this Agreement. 
 9. Supersedes Other Agreements. This Agreement supersedes and is in lieu of any and all other consulting and
compensation arrangements among MPM, Contractor and the Company. 
 10. No Employment Relationship. The parties hereto
acknowledge and agree that Contractor is an employee of MPM and not an employee of the Company, and nothing herein shall be construed to be inconsistent with this relationship or status. MPM shall have sole responsibility for the payment of all
compensation due to Contractor and the withholding of all applicable federal, state or local taxes or contributions imposed under any unemployment insurance, social security, income tax or other tax law or regulation with respect to MPM’s or
Contractor’s performance of Services hereunder. 
 11. Amendments. Any amendment to this Agreement shall be made in
writing and signed by the parties hereto. 
 12. Enforceability. If any provision of this Agreement shall be invalid or
unenforceable, in whole or in part, then such provision shall be deemed to be modified or restricted to the extent and in the manner necessary to render the same valid and enforceable, or shall be deemed excised from this Agreement, as the case may
require, and this Agreement shall be construed and enforced to the maximum extent permitted by law as if such provision had been originally incorporated herein as so modified or restricted or as if such provision had not been originally incorporated
herein, as the case may be. 

 13. Governing Law. This Agreement shall be construed and interpreted in accordance with the
internal laws of the Commonwealth of Massachusetts, without reference to conflicts of laws principles thereunder. 
 14. Assignment. 

 (a) By the Company. The rights and obligations of the Company under this Agreement shall inure to the benefit
of, and shall be binding upon, the successors and assigns of the Company. 
 (b) By MPM or Contractor. This
Agreement and the obligations created hereunder may not be assigned by MPM or Contractor and any such purported assignment shall be null and void ab initio. 
 15. Notices. All notices, requests, consents and other communications hereunder to any party shall be deemed to be sufficient if contained in a written instrument delivered in person or duly sent by
certified mail, postage prepaid; by an overnight delivery service, charges prepaid; or by confirmed facsimile; addressed to such party at the address set forth below or such other address as may hereafter be designated in writing by the addressee to
the addressor: 
 If to the Company: 
 Elixir Pharmaceuticals, Inc. 
 12 Emily Street 
 Cambridge, MA 02139 
 Attention: CEO 
 Facsimile: (617) 995-7050 
 If to MPM or
Contractor: 
 MPM Asset Management LLC 
 200 Clarendon Street 
 Boston, Massachusetts 02116 
 Attention: John W. Vander Vort, General Partner and COO 
 Facsimile: (617) 425-9201 
 Any party may from time to time change its address for the purpose of notices to that party by a similar notice specifying a new address, but no such change shall be
deemed to have been given until it is actually received by the party sought to be charged with its contents. 
 16. Waivers. No
claim or right arising out of a breach or default under this Agreement shall be discharged in whole or in part by a waiver of that claim or right unless the waiver is supported by consideration and is in writing and executed by the aggrieved party
hereto or its duly authorized agent. A waiver by any party hereto of a breach or default by the other party hereto of any provision of this Agreement shall not be deemed a waiver of future compliance therewith, and such provisions shall remain in
full force and effect. 

 17. Counterparts. This Agreement may be executed in one or more counterparts, each of which
shall be deemed an original, and all of which together shall be deemed to be one and the same instrument. 
 IN WITNESS WHEREOF, this
Agreement has been executed by the parties as of the date first above written. 
  

			
	COMPANY
	Elixir Pharmaceuticals, Inc.
		
	By:	 	/s/ William K. Heiden
	Name:	 	William K. Heiden
	Title:	 	President & CEO
	Date:	 	May 24, 2007
	
	MPM ASSET MANAGEMENT LLC
		
	By:	 	/s/ John W. Vander Vort
	Name:	 	John W. Vander Vort
	Title:	 	General Partner and Chief Operating Officer
	Date:	 	May 7, 2007
	
	CONTRACTOR
	John McDonald
	
	/s/ John McDonald
	Date:	 	May 7, 2007

 AMENDMENT NO.1 TO SERVICES AGREEMENT 
 THIS AMENDMENT NO. 1 TO SERVICES AGREEMENT is effective as of July 24, 2007 among Elixir Pharmaceuticals, Inc. (the “Company”), MPM
Asset Management, LLC (“MPM”), and John McDonald (“Contractor”). Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Services Agreement (as defined below). 
 Recitals: 
 WHEREAS, the
Company, MPM and Contractor entered into that certain Services Agreement dated as of March 1, 2007 (the “Services Agreement”); 
 WHEREAS, Section 11 of the Services Agreement provides that any amendment to the Services Agreement shall be made in writing and signed by the Company, MPM and Contractor; and 
 WHEREAS, the Company, MPM and Contractor desire to amend the Services Agreement pursuant to the terms of this Amendment. 
 NOW, THEREFORE, in consideration of the premises and covenants set forth herein, the parties hereto, intending to be legally bound, do hereby agree as
follows: 
 1. Exhibit A of the Services Agreement is hereby amended and restated to read in its entirety as follows: 
 “Contractor is engaged to provide senior business development services with respect to identifying, evaluating, pursuing and negotiating potential
transactions (e.g., license, corporate equity investment, collaboration, corporate partnership, etc.) regarding the Company’s Ghrelin agonist and/or Sirtuin program. 
 Contractor shall devote 33-1/3% of his business time to fulfill his duties and responsibilities during the term of this Agreement. Contractor shall have no obligation to work any particular schedule.” 

2. Exhibit B of the Services Agreement is hereby amended and restated to read in its entirety as follows: 
 “Additional consideration shall consist of: 
 Stock Options: 
 Stock options to Consultant covering 100,000 shares of Company Common Stock with an exercise price equal to
the fair market value set by the Board at grant, which grant is intended to occur at the next Board meeting after the parties enter into this Agreement. 

 If a written term sheet with a corporate partner or licensee (including a binding option) regarding the
Ghrelin agonist and/or Sirtuin program is executed by the Company and such corporate partner or licensee, stock options to Consultant covering an additional 25,000 shares of Company Common Stock with an exercise price equal to the fair market value
set by the Board at grant, which grant is intended to occur at the next Board meeting after the parties enter into this Agreement. 
 If a
transaction is completed with that corporate partner or licensee regarding the Ghrelin agonist and/or Sirtuin program (other than a term sheet)-, stock options to Consultant covering an additional 50,000 shares of Company Common Stock with an
exercise price equal to the fair market value set by the Board at grant, which grant is intended to occur at the next Board meeting after the parties enter into this Agreement. 
 All options granted hereunder shall be fully vested upon issuance and exercisable for the maximum period allowed under the stock option plan from which
they were granted. 
 Cash Bonus: 
 One percent (1%) of any Upfront Payments other than equity, to be paid to MPM. “Upfront Payments” shall mean cash payments made or to be made in connection with the execution of the agreement for a Ghrelin agonist and/or
Sirtuin transaction and shall include any delayed signing payments as may be contemplated by certain transactions relating to the completion of certain experiments. 
 Cash equal to one percent (1%) of any premium associated with the purchase of equity of the Company, to be paid to MPM, defined as the price paid by a corporate partner above that paid by the most recent
investors in the Series C round for preferred stock ($1.00 per share). 
 Cash equal to three quarters of one percent (0.75%) of any equity of
the Company purchased by a corporate partner in connection with the execution of the agreement for the Ghrelin agonist and/or Sirtuin transaction for which the 1% above is not paid, to be paid to MPM. 
 Any such cash bonus shall be paid within two business days of receiving the funds from the corporate partner in such transaction. 
 Other: 
 All additional consideration
described herein shall apply to any Ghrelin agonist and/or Sirtuin related transaction executed in accordance with the terms of the related term sheet thereto with that corporate partner or licensee; provided, however, that the grant of options on
the first 100,000 shares shall not be dependent on executing such transaction in 2007.” 

 3. The Company, MPM and Contractor each agree that the Company and Contractor will amend that
certain stock option agreement by and between the Company and Contractor in connection with and pursuant to the terms of the Services Agreement to reflect the terms set forth in this Amendment. 
 4. This Amendment shall take effect as of the date hereof. All other terms and provisions of the Services Agreement not expressly modified by this
Amendment shall remain in full force and effect and are hereby expressly ratified and confirmed. 
 5. If any provision of this
Amendment shall be invalid or unenforceable, in whole or in part, then such provision shall be deemed to be modified or restricted to the extent and in the manner necessary to render the same valid and enforceable, or shall be deemed excised from
this Amendment, as the case may require, and this Amendment shall be construed and enforced to the maximum extent permitted by law as if such provision had been originally incorporated herein as so modified or restricted or as if such provision had
not been originally incorporated herein, as the case may be. 
 6. This Amendment shall be construed and interpreted in accordance
with the internal laws of the Commonwealth of Massachusetts, without reference to conflicts of laws principles thereunder. 
 7. This
Amendment may be executed in one or more counterparts, each of which shall be deemed an original, and all of which together shall be deemed to be one and the same instrument. 

 IN WITNESS WHEREOF, this Amendment has been executed by the parties as of the date first above written.

  

			
	 COMPANY
 Elixir Pharmaceuticals,
Inc.

		
	By:	 	/s/ William K. Heiden
	Name:	 	William K. Heiden
	Title:	 	President & CEO
	Date:	 	July 24, 2007
	
	MPM ASSET MANAGEMENT LLC
		
	By:	 	/s/ John W. Vander Vort
	Name:	 	John W. Vander Vort
	Title:	 	General Partner and Chief Operating Officer
	Date:	 	July 24, 2007
	
	 CONTRACTOR
 John
McDonald

	
	/s/ John McDonald
	Date:	 	July 24, 2007

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