Document:

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                                                                   EXHIBIT 10.16

                              CONSULTING AGREEMENT

                        Effective as of February 28, 2006

      AMICUS THERAPEUTICS, INC. (the "Company"), a Delaware corporation, having
its place of business at 6 Cedar Brook Drive, Cranbury, NJ 08512 and Donald J.
Hayden, Jr. ("Consultant"), residing at 9 Larkspur Lane, Newtown, PA 18940
hereby agree as follows:

1. Basis for Agreement. The Company is engaged in the business of developing
inventions, know-how and trade secrets, and marketing and selling products
pertaining to the Technological Field (as hereinafter defined) ("Business").
Consultant is an experienced executive in the pharmaceutical field and desires
to aid in the Company's executive management and leadership. The purpose of this
Agreement is to set forth the terms and conditions under which Consultant will
provide consulting services and work product.

2. Definitions. For the purposes of this Agreement, the following terms when
used in the singular or plural shall have the following meanings:

2.1 Effective Date. The term "Effective Date" shall mean the date first above
written.

2.2 Technological Field. The term "Technological Field" shall mean the research,
development and/or commercialization of pharmacological or other small molecule
approaches to the treatment of genetic diseases.

3. Consulting Services. The following provisions shall relate to the terms and
conditions of consulting services to be rendered by Consultant to the Company
hereunder:

3.1 Consulting Term. Subject to the terms and conditions contained herein, the
Company agrees to retain Consultant and Consultant agrees to serve as a
consultant for a term commencing with the Effective Date and ending on the
second (2nd) anniversary of the Effective Date. Thereafter, the consulting term
and this Agreement shall be automatically extended on a year-to-year basis
unless otherwise terminated in accordance with Section 8.

3.2 Duties. Subject to the terms and conditions contained herein, Consultant
agrees to render services to the Company in the areas of executive management,
commercialization, business development and leadership.

3.3 Availability. Consultant shall make himself available to the Company for
consulting services as described herein when and as reasonably required by the
Company. Consultant agrees to provide the equivalent of 20% of his working time
to the

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Company on a mutually flexible, agreeable and convenient time. Such consulting
services shall be carried out at the Company's offices or elsewhere as may be
agreed between the parties to this Agreement. It is expressly understood that
Consultant will arrange the times to render consulting services to meet the
requirements of the Company, which will give due consideration to Consultant's
work habits, and to Consultant's obligations to the Company.

4. Confidentiality Agreement. Consultant shall execute and deliver a
Confidentiality Agreement substantially in the form attached hereto as Exhibit
A.

5. Compensation.

5.1 Fees. Consultant shall receive an annual fee of $60,000 for services as a
consultant to the Company. This fee shall be payable monthly in arrears.

5.2 Reimbursement. The Company shall reimburse Consultant for Consultant's
reasonable, documented out-of-pocket expenses.

6. Independent Contractor. Consultant's relationship to the Company under this
Agreement is that of an independent contractor. Consultant is not an agent,
joint venturer, partner, or employee of the Company. No act or obligation,
express or implied, of the Consultant is in any way binding upon the Company
except as expressly set forth herein. Consultant is responsible for obtaining
all necessary licenses and permits for the conduct of Consultant's business and
in all other ways fully complying with the requirements of applicable laws,
including but not limited to the payment of all income and withholding taxes
with respect to payments from the Company pursuant to this Agreement.

7. Warranty. Consultant represents and warrants that he (i) has the right and
authority to enter into this Agreement and to perform his obligations as
described in this Agreement; (ii) shall perform such obligations in a
professional manner; (iii) will not infringe on, violate or misappropriate any
patent, copyright, trade secret, trademark or other proprietary right of any
entity in performing such obligations; and (iv) is free to enter into and
perform this Agreement without violating the provisions of any other agreement,
written or oral, to which he is a party.

8. Termination. This Agreement may be terminated by either party at any time
upon thirty (30) days prior written notice to the other.

9. Miscellaneous Provisions. The following miscellaneous provisions shall also
apply to this Agreement:

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9.1 Notices. All notices and communications provided for hereunder shall be in
writing and shall be mailed or delivered to the business address of the parties
to this Agreement, or to such other address as either party shall designate in
writing to the other.

9.2 Successors and Assigns. The rights and obligations of the Company under this
Agreement shall bind and inure to the benefit of the Company and its successors
and assigns. The Company shall have the right to freely assign, delegate, or
transfer any of its rights and obligations under this Agreement. The rights and
obligations of Consultant under this Agreement are personal to Consultant and
may not be assigned, delegated or transferred without the prior written consent
of the Company, except for the right to payment hereunder.

9.3 Governing Law. This Agreement shall be governed by and interpreted in
accordance with the laws of the State of New Jersey, without regard to the
conflicts of laws rules thereof.

9.4 Entire Agreement. This Agreement constitutes the entire understanding
between the parties hereto with respect to the subject matter hereof. No
modifications, extension or waiver of any provisions hereof or any release of
any right hereunder shall be valid, unless the same is in writing and is
consented to by both parties hereto.

9.5 Headings. The headings in this Agreement are intended solely for convenience
of reference and shall be given no effect in the construction or interpretation
of this Agreement.

9.6 Counterparts. This Agreement may be executed simultaneously in multiple
counterparts, each of which shall be deemed to be an original but all of which
together shall constitute one and the same Agreement.

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      IN WITNESS WHEREOF, the parties hereto have executed this Consulting
Agreement as of the date first written above.

                                      AMICUS THERAPEUTICS, INC.

                                      By: /s/ John F. Crowley
                                          -----------------------------------
                                          Name: John F. Crowley
                                          Title: Chief Executive Officer

                                      CONSULTANT

                                      /s/ Donald J. Hayden, Jr.
                                      -----------------------------
                                      Signature

                                      SS# or EIN: (omitted)

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                                    EXHIBIT A

February 28, 2006

Donald J. Hayden, Jr.
9 Larkspur Lane
Newtown, PA 18940

Re: Confidentiality Agreement ("Agreement")

Dear Don:

In connection with your engagement as a consultant (the "Relationship") with
Amicus Therapeutics, Inc. (the "Company"), the Company expects to make available
to you certain nonpublic information concerning its businesses, financial
condition, operations, assets and liabilities. As a condition to such
information being furnished to you and your partners, directors, officers,
employees, agents, advisors, and your affiliated or subsidiary companies
(including, without limitation, attorneys, accountants, consultants, bankers and
financial advisors) (collectively, "Representatives"), you agree to treat any
nonpublic information concerning the Company (whether prepared by the Company,
its Representatives or otherwise and irrespective of the form of communication)
which is furnished hereunder to you or to your Representatives by or on behalf
of the Company in accordance with the provisions of this Agreement, and to take
or abstain from taking certain other actions hereinafter set forth.

            1. CONFIDENTIAL INFORMATION.

                  (a) "Trade Secrets" shall mean information belonging to the
Company or its Representatives (collectively, the "Disclosing Party") or
licensed by it including, without limitation, formulae, patterns, compilations,
programs, devices, methods, techniques, or processes (including such information
that has commercial value to the Disclosing Party from a negative viewpoint,
such as the results of research which proves that certain processes used to
attempt to develop new technology will be unsuccessful), which is not commonly
known by or available to the public, was not your or your Representatives'
(collectively, the "Receiver") legitimate possession prior to the time of
entering this Agreement, and which information: (a) derives independent economic
value, actual or potential, from not being generally known to, and not being
readily ascertainable by proper means by, other persons who can obtain economic
value from their disclosure or use; and (b) is the subject of efforts that are
reasonable under the circumstances to maintain its secrecy.

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                  (b) "Proprietary Information" shall mean any information,
other than Trade Secrets, without regard to form, belonging to the Disclosing
Party or licensed by it including, without limitation, formulae, patterns,
compilations, programs, devices, methods, techniques, or processes, which is not
commonly known by or available to the public and which information is material
to the Disclosing Party, and all notes, analyses, compilations, studies,
interpretations or other documents prepared by the Receiver which contain,
reflect or are based upon, in whole or in part, the information furnished to the
Receiver by the Disclosing Party pursuant hereto; provided, however that
"Proprietary Information" shall not include any information which Receiver can
show (i) is or shall become generally known to the industry or the public
through no act or fault of Receiver, (ii) is received in good faith from any
third party who has the right to disclose such information and who has not
received such information, either directly or indirectly, from the Disclosing
Party, or (iii) any information which Receiver can show was in Receiver's
legitimate possession prior to the time of entering this Agreement.

                  (c) "Confidential Information" shall mean, collectively, both
Proprietary Information and Trade Secrets that are disclosed to the Receiver (a)
in documents or other tangible materials clearly marked as proprietary and
delivered to the recipient by the disclosing party, or (b) orally, or in any
other intangible form, provided, however, when first disclosed to the recipient,
the disclosing party tells the recipient the information is proprietary, and the
information is described and disclosed in documents or other tangible materials
clearly marked as proprietary and then delivered to the Receiver by the
Disclosing Party within thirty (30) calendar days after the information is first
disclosed to the Receiver.

            2. USE OF CONFIDENTIAL INFORMATION. You hereby agree that you and
your Representatives shall use the Confidential Information solely for the
purpose of evaluating a possible Relationship, and that the Confidential
Information will be kept confidential and you and your Representatives will not
disclose or use for purposes other than as permitted herein any of the
Confidential Information in any manner whatsoever; provided, however, that you
may make any disclosure of Confidential Information to your Representatives (i)
who need to know such information for the sole purpose of evaluating a possible
Relationship between the parties, (ii) who are provided with a copy of this
letter agreement and (iii) who agree to treat such information confidentially.
In addition to the foregoing, you agree as follows:

                  (a) Receiver will treat as confidential and will not, without
the prior written approval of the Disclosing Party, use (other than as set forth
herein), publish, disclose, copyright or authorize anyone else to use, publish,
disclose or copyright, either during the term of this Agreement or at any time
subsequent thereto, any information that constitutes Trade Secrets whether or
not the Trade Secrets are in written or tangible form.

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                  (b) Receiver will treat as confidential and will not, without
the prior written approval of the Disclosing Party, use (other than in the
performance of the purpose described in this Agreement), publish, disclose,
copyright or authorize anyone else to use, publish, disclose or copyright, any
Proprietary Information either during the term of this Agreement or for five (5)
years after the expiration or termination of this Agreement, with or without
cause, and whether or not the Proprietary Information is in written or other
tangible form.

            3. REQUIRED DISCLOSURE. In the event you or your Representatives are
requested or required (by oral questions, interrogatories, requests for
information or documents in a legal proceeding, subpoena, civil investigative
demand or other similar process) to disclose any of the Confidential
Information, you or your Representatives so requested or required shall provide
the Company with prompt notice of any such request or requirement so that the
Company may seek a protective order or other appropriate remedy and/or waive
compliance with the provisions of this letter agreement. If, in the absence of a
protective order or other remedy or the receipt of a waiver by the Company, you
or your Representatives are nonetheless, in the opinion of outside counsel,
legally compelled to disclose the Confidential Information, you or your
Representatives may, without liability hereunder, disclose to such tribunal only
that portion of the Confidential Information which such counsel advises is
legally required to be disclosed, provided, however, that you or your
Representatives exercise reasonable efforts to preserve the confidentiality of
the Confidential Information, including, without limitation by cooperating with
the Company to obtain an appropriate protective order or other reliable
assurance that confidential treatment will be accorded the Confidential
Information by such tribunal.

            4. RETURN OF CONFIDENTIAL INFORMATION. Upon termination of this
Agreement and at any time upon the request of the Company for any reason, you
will (i) promptly deliver to Company or destroy all written Confidential
Information furnished to you by or on behalf of the Company pursuant hereto (and
all copies-thereof and extracts therefrom) and (ii) promptly destroy all written
Confidential Information prepared by you which contain, reflect or are based
upon, in whole or in part, the information furnished to you by the Company
pursuant hereto (and all copies thereof and extracts therefrom) and such return
or destruction shall be certified in writing by your authorized officer;
provided, however, that in either case a copy may be retained by counsel of each
party solely for the purposes of maintaining an accurate record of the
Confidential Informations should a dispute under this letter agreement ever
arise. Notwithstanding the return or destruction of Confidential Information,
you and your Representatives will continue to be bound by their other
obligations as provided in this Agreement.

            5. NO REPRESENTATION OF ACCURACY. You understand and hereby
acknowledge that neither the Company nor any of its Representatives makes any
representation or warranty, express or implied, as to the accuracy or
completeness of the

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Confidential Information made available by it. You agree that neither the
Company nor any of its Representatives shall have any liability to you or your
Representatives relating to or resulting from the use of, or reliance upon, the
Confidential Information or any errors therein or omissions therefrom.

            6. MISCELLANEOUS. You agree to be responsible for any breach of this
agreement by any of your Representatives. No failure or delay by the Company or
any of its Representatives in exercising any right, power or privileges under
this agreement shall operate as a waiver thereof nor shall any single or partial
exercise thereof preclude any other or further exercise of any right, power or
privilege hereunder. In case any provision of this agreement shall be invalid,
illegal or unenforceable, the validity, legality and enforceability of the
remaining provisions of this agreement shall not in any way be affected or
impaired thereby.

            7. GOVERNING LAW. This Agreement shall be governed by, and construed
in accordance with, the internal laws of the State of New Jersey without giving
effect to the principles of conflicts of laws thereof.

            8. COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

            9. TERM. Confidential Information may be disclosed hereunder until
the date that is one year from the date first written above unless otherwise
terminated or extended in writing by the parties. Notwithstanding the
termination of this Agreement, the obligations with respect to the use of
confidential information contained in Section 2 shall survive.

Please confirm your agreement with the foregoing by signing and returning one
copy of this letter to the undersigned, whereupon this letter agreement shall
become a binding agreement.

                                            Very truly yours,

                                            AMICUS THERAPEUTICS, INC.

                                            By: /s/ John F. Crowley
                                                -------------------------
                                            Name: John F. Crowley
                                            Title: CEO

Accepted and Agreed as of
the date first written above:

By: /s/ Donald J. Hayden, Jr.
    --------------------------
Name: Donald J. Hayden, Jr.

                                  Page 8 of 8<PAGE>
                                                                   EXHIBIT 10.17

[AMICUS THERAPEUTICS LOGO]

May 12,2006

Mr. Douglas Branch
1816 Winding Ridge Road
Norman, Ok 73072

 Dear Doug:

         On behalf of Amicus Therapeutics, Inc. (the "Company"), I am pleased to
confirm our offer to you for the position of Vice President & General Counsel
reporting to me. Your start date will be mutually agreed upon but no later then
June 5, 2006. With this offer you agree to devote no less then two-thirds of
your time and professional efforts to Amicus Therapeutics.

         Prior to the commencement of your employment you will be required to
execute the Company's Confidentiality, Disclosure and Non-Competition Agreement.
A copy of this agreement is attached. In addition, as a condition of employment
Amicus requires a pre-employment drug screening.

         In consideration for all your services to be rendered to the Company
your annual base salary will be $200,000, to be paid bi-weekly in accordance
with the Company's payroll practices. Upon the completion of mutually agreed
upon individual goals and objectives as well as the achievement of specific
Company goals, you will be eligible to receive a year end bonus target of 25% of
your base salary, prorated for your date of hire, minus customary deductions.

         Upon approval by the Board of Directors, you will receive an incentive
stock option to purchase 100,000 shares of the Company's common stock, par value
$.01 per share (the "Common Stock") pursuant to a stock option agreement in form
and substance acceptable to the Company. The options will become exercisable
over a four-year period as follows: 25% on the first anniversary of the date of
grant, and the remaining 75% in equal monthly increments thereafter. The
exercise price of the options will be the fair market value of the Company's
common stock on the date of grant. Shares issuable upon exercise of each option
will be subject to certain transfer restrictions including the right of first
refusal. Additionally, exercise of the options will be governed in accordance
with the provisions of the Company's stock option plan.

         You will be eligible to participate in the Company's health benefits
program and are eligible to participate in the Company's 401(k) as well as any
other employee benefit plan(s) that are generally made available by the Company
to its employees from time to time when and as the Company may make them
available.

<TABLE>
<S>                   <C>                  <C>               <C>               <C>
6 Cedar Brook Drive   Cranbury, NJ 08512   T: 609-662-2000   F: 609-662-2001   www.amicustherapeutics.com
</TABLE>

<PAGE>

Douglas Branch
May 12, 2006
Page #2 of 4

         You will be eligible for paid Company holidays as outlined in our
Holiday Policy and you will be eligible for twenty (20) days paid vacation,
three weeks during the year and one between Christmas and New Years. Vacation
accrues on a monthly basis. Because the Company expects to regularly review its
benefit programs to keep them up to date and competitive, these programs are
subject to periodic adjustments so that certain features may be added, modified
or deleted over time.

         From your date of hire until October 1, 2006, you primary place of
business will be Oklahoma City, OK and you will be expected to be in NJ
approximately 2 days per week. After October 1, 2006 your primary place of
business will be Cranbury NJ. Given that you currently reside over 50 miles from
our location in Cranbury NJ, you will be eligible to receive our "Homeowners
Relocation Program". The details of which are enclosed. You must complete your
entire move within 12 months of October 1, 2006. Should you voluntarily resign
your employment within 12 months of October 1, 2006, you will owe the company
the appropriate prorated portion of this relocation.

         In the event that your employment is terminated by the Company, except
for "Cause" as defined below, you will be eligible for a continuation of six (6)
months salary at the rate in effect at the time of termination following such
termination ("Severance Pay"). "Cause" means for any of the following reasons
(i) willful or deliberate misconduct by you that materially damages the company;
(ii) misappropriation of company assets; (iii) conviction of, or a plea of
guilty or "no contest" to, a felony or (iv) any willful disobedience of the
lawful and unambiguous instructions of the CEO of the Company; provided that the
CEO has given you written notice of such disobedience or neglect and you have
failed to cure such disobedience or neglect within a period reasonable under the
circumstances. Payment of Severance by the Company will be subject to and
contingent upon your signing a waiver of rights releasing the Company from any
and all further liability or responsibility.

Change in Control

         If there is a Change in Control Event and you resign for Good Reason or
are terminated without Cause within six months of such Change in Control Event,
then (i) you will be eligible to receive a continuation of twelve (12) months
salary, plus payment of a bonus payment equal to the bonus earned in the
preceding year and (ii) all unvested stock options will have their remaining
vesting schedule accelerated so that all stock options are fully vested.

         "Change in Control Event" means any of the following: (i) any person or
entity (except for a current stockholder) becomes the beneficial owner of
greater than 50% of the then outstanding voting power of the company; (ii) a
merger or consolidation with another entity where the voting securities of the
company outstanding immediately before the transaction constitute less than a
majority of the voting power of the voting securities of the company or the
surviving entity outstanding immediately after the transaction or (iii) the sale
or disposition of all or substantially all of the company's assets. "Good
Reason" means (a) a change in your position with the company or its successors
that

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Douglas Branch
May 12, 2006
Page #3 of 4

company or its successor greater than 50 miles away from the then current
location of the company's principal officers.

         Your right to receive accelerated vesting and salary continuation
payments pursuant to the preceding two paragraphs will be subject to and
contingent upon your signing a waiver of rights releasing the Company from any
and all further liability or responsibility.

         It is important that you understand that the Company does not guarantee
employment for any specific period of time. You will be employed on an "at-will"
basis. This means that both the Company and you will have the right to terminate
your employment at any time, for any reason, with or without prior notice or
cause. Neither you nor the Company will have any express or implied contract
limiting your right to resign, or the Company's right to terminate your
employment, at any time, for any reason, with or without prior notice or cause.

         In accordance with the Immigration and Naturalization Control Act, all
new employees must provide documentation that they have the legal right to work
in the United States. A copy of Form I-9 and a list of the acceptable documents
confirming your right to work in the United States are also attached for your
convenience.

         To indicate your acceptance of our offer, please sign one copy of this
letter in the space indicated below and return it to the attention of Nicole
Schaeffer, Vice President of Human Resources & Leadership Development by May
19, 2006. Acceptance of this offer constitutes your agreement with all of the
above terms and conditions of employment with Amicus Therapeutics, Inc., and
constitutes agreement to conform to Amicus Therapeutics, Inc. rules and
procedures. By signing below, you agree that no other promises, express or
implied, have been made to you either verbally or in writing and that no further
modifications to these terms and conditions will be effective except by a
written agreement signed by the Chief Executive Officer of the Company and you.

<PAGE>

Douglas Branch
May 12, 2006
Page #4 of 4

         The formality of this letter not withstanding, I extend my personal
best wishes and sincere pleasure that you are joining our team. I look forward
to working with you.

Sincerely,

/s/ John F. Crowley

John F. Crowley
President & CEO

I accept the offer of employment under the terms and conditions stated above. No
other promises, express or implied, have been made to me either verbally or in
writing.

By: Douglas Branch                                        Date: May 15, 2006

/s/ Douglas Branch

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