Document:

ecyt_Ex10_1

		
			Exhibit 10.1
		

		
			 
		

		
			CONFIDENTIAL TREATMENT REQUESTED
		

		
			Portions of this Exhibit have been redacted pursuant to a request for confidential treatment under Rule 24b-2 of the General Rules and Regulations under the Securities Exchange Act of 1934, as amended. Omitted information, marked “[*]” in this Exhibit, has been filed separately with the Securities and Exchange Commission together with such request for confidential treatment.
		

		
			 
		

		
			LICENSE AGREEMENT
		

		
			 
		

		
			BETWEEN
		

		
			 
		

		
			ENDOCYTE, INC
		

		
			 
		

		
			AND
		

		
			 
		

		
			PURDUE RESEARCH FOUNDATION
		

		
			 
		

		
			OCTOBER 21, 1998
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.  

					
						   

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDED AND RESTATED EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDED AND RESTATED EXCLUSIVE LICENSE AGREEMENT is entered on this 21st day of October, 1998 (the “Amended and Restated Effective Date”) and it amends and restates the EXCLUSIVE LICENSE AGREEMENT entered into on the 17th day of July, 1998 and shall be effective as of the 21st day of December, 1995 (“Effective Date”) by and between PURDUE RESEARCH FOUNDATION, a corporation of Indiana having an address at West Lafayette, Indiana 47907 (hereinafter “PRF”), and Endocyte Corporation, an Indiana corporation, having a place of business at Lafayette, Indiana (hereinafter “LICENSEE”), PRF and LICENSEE collectively referred to hereinafter as “the Parties.”
		

		
			 
		

		
			WITNESSETH:
		

		
			 
		

		
			WHEREAS, PRF is the owner by assignment of those United States Patents and corresponding patents in other countries all as set forth in Appendix A attached hereto (hereinafter, together with all divisions, continuations, continuations-in-part, foreign counterparts, and reissues thereof, called the “Patents”); and
		

		
			 
		

		
			WHEREAS, PRF and LICENSEE have previously executed an amendment to the Exclusive License Agreement (Appendix B), on July 17, 1998 and December 2, 1996 effective as of December 21, 1995. LICENSEE and PRF agree that the terms and conditions of this Exclusive License Agreement shall supercede and take precedence over the previous Exclusive License Agreement (Appendix B) signed on July 17, 1998.
		

		
			 
		

		
			WHEREAS, LICENSEE desires license rights under such Patents and PRF is willing to grant such license rights under the terms and conditions hereinafter set forth;
		

		
			 
		

		
			NOW, THEREFORE, in consideration of the mutual promises and undertakings hereinafter set forth, the Parties hereto agree as follows:
		

		
			 
		

		
			ARTICLE I — DEFINITIONS
		

		
			 
		

		
			As used herein, the following terms shall have the following meanings:
		

		
			 
		

			
					
						 

					
					
						1.1

					
					
						“Affiliate” shall mean a corporation, company, partnership, or other business entity which controls or is controlled by, or is under common control with, the designated party. In the case of a corporation or company, “control” means ownership either directly or indirectly of at least fifty percent (50%) of the shares of stock entitled to vote for the election of directors. The term “Affiliate” shall not include a third-party sublicensee of LICENSEE.

				

		
			 
		

			
					
						 

					
					
						1.2

					
					
						“FDA Approval” shall mean final approval from the United States Food and Drug Administration to distribute, market and sell any Licensed Product in the United States.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						   

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						 

					
					
						1.3

					
					
						“Licensed Products” shall mean products falling within the scope of a Valid Claim or claims of the Patents or made by processes within the scope of a Valid Claim or claims of the Patents.

				

		
			 
		

			
					
						 

					
					
						1.4

					
					
						“Sales Value” shall mean (i) in the case of Licensed Products sold to third parties, the invoice price, F.O.B place of manufacture, exclusive of sales taxes, packing, shipping and insurance charges, and less returns, allowances, and discounts actually allowed; and (ii) in the case of any use of any Licensed Product by LICENSEE, any Affiliate or any third party for the purpose of any testing or studies necessary to obtain FDA Approval, Zero Dollars ($0.00).

				

		
			 
		

			
					
						 

					
					
						1.5

					
					
						“Valid Claim” shall mean any claim contained in any pending patent application or issued patent included within the Patents which has not been abandoned or declared invalid in a non-appealable order, as the case may be, and which would be infringed by the manufacture, use or sale of Licensed Products in the absence of the licenses granted hereunder.

				

		
			 
		

			
					
						 

					
					
						1.6

					
					
						“Territory” shall mean all countries, worldwide.

				

		
			 
		

			
					
						 

					
					
						1.7

					
					
						“Field of Use” shall mean:

				

		
			 
		

			
					
						 

					
					
						(a)

					
					
						All Diagnostic and Imaging Applications; and

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						All Therapeutic Applications.

				

		
			 
		

			
					
						 

					
					
						1.8

					
					
						“Therapeutic Applications” shall mean any use of a Licensed Product for the prevention or treatment of disease or injury.

				

		
			 
		

			
					
						 

					
					
						1.9

					
					
						“Diagnostic or Imaging Applications” shall mean any use of a Licensed Product for purposes of the investigation or determination of the nature or extent of any disease or injury.

				

		
			 
		

			
					
						 

					
					
						1.10

					
					
						“Know-How” shall mean any and all confidential unpatented and/or non-patentable data, materials, samples and other information owned and controlled by PRF which relate to the Patents or which is useful in the Manufacture, use or sale of Licensed Products.

				

		
			 
		

		
			ARTICLE II — GRANTS
		

		
			 
		

			
					
						 

					
					
						2.1

					
					
						PRF grants, subject to the terms of this Agreement, to LICENSEE a royalty-bearing, exclusive license under the Patents to make, to have made, use, sell and import and sell Licensed Products in the Field of Use in the Territory.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						 

					
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						2.2

					
					
						PRF grants, subject to the terms of this Agreement, to LICENSEE a non-exclusive license under the Know-How to make, to have made, use, sell and import and sell Licensed Products in the Field of Use in the Territory.

				

		
			 
		

			
					
						 

					
					
						2.3

					
					
						LICENSEE shall have the right to grant sublicenses under the license granted herein, and to extend the sublicenses to any third party or Affiliate of LICENSEE. LICENSEE shall notify PRF promptly of any grant of sublicense hereunder and the terms thereof.

				

		
			 
		

			
					
						 

					
					
						2.4

					
					
						PRF shall reserve, and the license granted shall be subject to the royalty-free right in PRF (or in Purdue University, if PRF’s rights are assigned to the University) to make or have made for its use (but not to sell) the products or devices (or the rights to practice the process, if a process invention) under each patent, provided that such reserved rights shall be used by PRF (or the University as the case may be) solely for educational and research purposes and not for commercial purposes.

				

		
			 
		

			
					
						 

					
					
						2.5

					
					
						All rights reserved to the United States Government and others under Public Law 96-517 and 98-620 shall remain and shall in no way be affected by this Agreement. Portions of the Patents were developed under Grant 89-45-DC8-88-11465 awarded by the National Science Foundation.

				

		
			 
		

			
					
						 

					
					
						2.6

					
					
						PRF hereby warrants that it is the owner of the Patents and that such Patents are not subject to any lien, encumbrance, license or claim of ownership of any third party, except to the extent stated in Section 2.4, in derogation of the rights granted to LICENSEE in this Agreement.

				

		
			 
		

		
			ARTICLE III — DUE DILIGENCE
		

		
			 
		

			
					
						 

					
					
						3.1

					
					
						(a) LICENSEE shall use its commercially reasonable efforts to bring one or more Licensed Products in the Field of Use to market through program for exploitation of Patents. LICENSEE shall supply to PRF a business and project plan for the Licensed Products to PRF no later than twelve (12) months after the Effective Date.

				

		
			 
		

		
			(b) LICENSEE further agrees to secure $[*] to be expended for the testing and development of the Licensed Products. Once this initial funding of $[*] has been expended (the “Crossover Date”), LICENSEE shall provide evidence of obtaining Additional Support needed to develop the technology. Additional support shall be defined as:
		

		
			 
		

			
					
						 

					
					
						(I)

					
					
						Having secured additional funding of at least $[*]; or

				

		
			 
		

			
					
						 

					
					
						(II)

					
					
						Enter into a venture for the development and commercialization of the Diagnostic Imaging and Therapeutic applications of the Licensed Products.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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			(c) If after [*] after the Crossover Date the LICENSEE has not provided evidence of Additional Support, this Agreement may be terminated on written notice of PRF.
		

		
			 
		

		
			(d) LICENSEE further agrees to begin the development of Therapeutic Applications of the Licensed Products, other than those involving Gene Therapy, no later than [*] from the Effective Date.
		

		
			 
		

		
			(e) LICENSEE further agrees to provide evidence of being in bona fide negotiations or in-house development for Gene Therapy applications no later than [*] from the Effective Date.
		

		
			 
		

		
			(f) LICENSEE further agrees to provide $[*] over a three year period from Effective Date to fund research at Purdue University.
		

		
			 
		

			
					
						 

					
					
						3.2

					
					
						Commencing twenty-four (24) months following FDA Approval, if, at any time, PRF is of the reasonable opinion that LICENSEE is not meeting the public demand, as outlined below, for Licensed Products, PRF shall notify LICENSEE to that effect and LICENSEE shall have six (6) months after such notice within which to meet such demand or to make other arrangements satisfactory to PRF. If at the end of six (6) months’ period PRF is not satisfied that the public demand is or will be reasonably met by LICENSEE, PRF may, at its option, terminate the license or convert the exclusive license to a non-exclusive license upon sixty (60) days’ notice to LICENSEE. Net sales, based upon Sales Value, of [*] or more of the Licensed Products by LICENSEE and any sublicensees during the first twenty-four (24) following FDA Approval shall be regarded by PRF as meeting the public demand.

				

		
			 
		

		
			ARTICLE IV — PRF ROYALTY OBLIGATIONS
		

		
			 
		

			
					
						 

					
					
						4.1

					
					
						LICENSEE shall pay PRF licensing fees according to the following schedule:

				

		
			 
		

			
					
						 

					
					
						(a)

					
					
						$[*] on the Effective Date;

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						$[*] the Effective Date;

				

		
			 
		

			
					
						 

					
					
						(c)

					
					
						$[*] the Effective Date;

				

		
			 
		

			
					
						 

					
					
						(d)

					
					
						$[*] the Effective Date; and

				

		
			 
		

			
					
						 

					
					
						(e)

					
					
						$[*] the Effective Date.

				

		
			 
		

			
					
						 

					
					
						4.2

					
					
						Subject to all the terms and conditions of this Agreement, for each calendar year this Agreement is in effect, LICENSEE shall pay to PRF an earned royalty, which shall be agreed to in writing by the parties and which shall not exceed the maximum percentages set forth below, calculated as a percentage of the Sales Value of Licensed Products made, used, sold or imported by LICENSEE, it sublicensees or its Affiliates in each country of the Territory in which there is (are) valid unexpired Patents. The royalties due hereunder shall be payable on a country-by-country basis in each country until the expiration of the last to expire of the Patents covering the Licensed Products or the manufacture use or sale of the Licensed Products in such country. The royalty percentage shall be [*] of the Sales Value of Licensed Products used or sold.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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			At any time during the term of this Agreement, the parties shall be free to renegotiate, in good faith, the earned royalty percentages previously agreed to; provided that, in no event shall the renegotiated royalty percentages exceed the royalty percentages set forth above.
		

		
			 
		

			
					
						 

					
					
						4.3

					
					
						LICENSEE shall pay to PRF an annual minimum royalty for each calendar year during the life of this Agreement beginning in calendar year 1998. The minimum royalty shall be payable on or before December 31 of each such calendar year. The minimum royalties shall be as follows:

				

		
			 
		

			
					
						2002

					
					
						 

					
					
						$

					
5,000
					
					
						 

				
	
					
						2003

					
					
						 

					
					
						$

					
7,500
					
					
						 

				
	
					
						2004

					
					
						 

					
					
						$

					
10,000
					
					
						 

				
	
					
						2005

					
					
						 

					
					
						$

					
12,500
					
					
						 

				
	
					
						Each year thereafter

					
					
						 

					
					
						$

					
12,500
					
					
						 

				

		
			 
		

		
			If earned royalties for any calendar year do not equal or exceed the minimum royalty owed for that calendar year, LICENSEE shall pay PRF an amount equal to the difference between the calendar year earned royalty and the calendar year minimum royalty, said amount payable on or before January 31 of the next following calendar year.
		

		
			 
		

		
			ARTICLE V — RECORDS, REPORTS, PAYMENTS
		

		
			 
		

			
					
						 

					
					
						5.1

					
					
						LICENSEE shall keep accurate books and records showing all sales and use by LICENSEE and its sublicensee of Licensed Products, together with such other information as shall be necessary to enable earned royalties to be computed, and such books and records showing all sales and use by LICENSEE and its sublicensee of Licensed Products shall be kept for a period of three (3) years from the creation of such books and records. On or before the last day of March, June, September, and December of each year during the life of this Agreement, LICENSEE shall render to PRF a written report showing the calculation, in reasonable detail, of earned royalty for the preceding calendar quarter and shall accompany each such report with payment of any amount shown to be due. Such reports are to be made by LICENSEE whether or not royalties are owed. Such reports and any royalties due will be made to PRF within thirty (30) days of the end of each calendar quarter. Not more than once per calendar year during the term of this Agreement, LICENSEE’s records and books shall be open during reasonable business hours for reasonable inspection by a certified public accountant appointed and paid for by PRF and reasonably acceptable to LICENSEE, to determine the accuracy of such royalty statements and payments but for not other purpose. PRF agrees that it and its designees shall keep confidential and shall not disclose or use for purposes other than those set forth in Section 5.1, any information, report or document provided to or made available to PRF or its designee.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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			ARTICLE VI — PATENT PROSECUTION
		

		
			 
		

			
					
						 

					
					
						6.1

					
					
						As between PRF and LICENSEE, PRF shall have responsibility for filing, prosecution and maintenance of all Patents in the Territory. LICENSEE shall have the right to review pending Patent applications and make recommendations to PRF concerning them. PRF will consider in good faith all reasonable suggestions of LICENSEE with respect thereto. PRF agrees to keep LICENSEE informed of the course of patent prosecution or other proceedings with respect to the Patents within the Territory. In the event PRF elects not to file, prosecute or maintain any or all of the Patents in the Territory, PRF shall assign this responsibility to LICENSEE and cooperate to assure the filing, prosecution and maintenance of all Patents. The parties shall hold all information disclosed to it under this Section as confidential.

				

		
			 
		

			
					
						 

					
					
						6.2

					
					
						LICENSEE shall have the right but not the obligation to seek extensions of the terms of PATENTS in the Territory. At LICENSEE’S request, PRF shall either diligently seek to obtain such extensions or authorize LICENSEE to act as PRF’s agent for the purpose of making any application for any extensions of the term of Patents and provide reasonable assistance therefor to LICENSEE, in either event, at LICENSEE’s expense.

				

		
			 
		

			
					
						 

					
					
						6.3

					
					
						PRF shall promptly provide LICENSEE copies of all notices and correspondence to or from the U.S .Patent and Trademark Office and any foreign patent offices.

				

		
			 
		

			
					
						 

					
					
						6.4

					
					
						Payment of all fees and costs relating to the filing, prosecution, and maintenance of the Patents shall be the responsibility of LICENSEE, whether or not such fees and costs were incurred before or after the date of this Agreement. PRF acknowledges receipt of patent expenses in the amount of $209,705.41 (see Appendix C) which covers all prior patent expenses through April 30, 1998.

				

		
			 
		

			
					
						 

					
					
						6.5

					
					
						PRF will provide all requested Know-How to LICENSEE at LICENSEE’s expense.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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			ARTICLE VII— INFRINGEMENT/ENFORCEMENT
		

		
			 
		

			
					
						 

					
					
						7.1

					
					
						If during the term of this Agreement one ore more Patents licensed hereunder is or appears to be infringed by a third party within the Field of Use, then the party having knowledge thereof shall notify the other and the parties shall consult to consider what, if any, action should be taken. Under no circumstances shall PRF have the obligation to enforce Patents. LICENSEE shall have the first right (but not the obligation) to notify the infringer and/or initiate litigation or legal proceedings to abate the infringement. In the event LICENSEE commences litigation, LICENSEE shall notify PRF in writing that the litigation has been commenced. PRF may elect to join in any such legal proceedings against the alleged infringer. In the event LICENSEE has not initiated such legal proceedings within six (6) months after becoming aware of the infringement, then PRF may initiate such legal proceedings on its own behalf; and thereafter, LICENSEE may elect to join in those proceedings.

				

		
			 
		

			
					
						 

					
					
						7.2

					
					
						If PRF elects to join in legal proceedings commenced by LICENSEE or sublicensee, or if LICENSEE or sublicensee elected to join in legal proceedings commanded by PRF, all fees and costs incurred therein, and all damages shall be the responsibility of PRF. If one Party elects not to join in legal proceedings initiated by the other Party, then the initiating Party shall be responsible for all fees and costs incurred therein. All reasonable costs and expenses incurred as a result of said legal proceedings shall be recoverable by LICENSEE or sublicensee out of damages and awards recovered by LICENSEE, sublicensee and/or PRF. Any remaining amounts from damages and awards, once costs and expenses have been recovered, shall be divided between LICENSEE and PRF as follows: LICENSEE shall retain seventy-five percent (75%) and PRF shall retain twenty-five percent (25%) of the damages and awards recovered by LICENSEE. Each Party shall reasonably cooperate with the other Party, whether joining or not, in the conduct of the proceedings (such as by joining in name only); however, where PRF is joined in any such legal proceedings in name only as a necessary party and not at its election, then LICENSEE shall indemnify and hold harmless PRF from and against any and all actions, claims, and counterclaims brought against PRF, and LICENSEE agrees to pay all legal expenses, damages, and costs which may be finally assessed against PRF in such actions, claims, and counterclaims.

				

		
			 
		

			
					
						 

					
					
						7.3

					
					
						PRF makes no warranty that the subject matter of the invention licensed hereunder will not infringe any third party patent and PRF makes no covenant either to defend any infringement charge by a third party or to institute action against infringers of any Patents hereby licensed.

				

		
			  
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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						7.4

					
					
						If LICENSEE, any sublicensee or customer is named as a defendant in a lawsuit (hereinafter “Defendant”) charging Defendant with patent infringement as a result of its manufacture or sale of Licensed Products or its use of Licensed Products as disclosed in Patents or otherwise contending that Defendant does not have the right to manufacture, sell or so use Licensed Products, and LICENSEE so notifies PRF that such a lawsuit has been filed and provides PRF with copies of the Complaint and all papers associated with its filing. LICENSEE shall have the right to establish an Escrow Account for the mutual benefit of PRF and LICENSEE. For so long as LICENSEE bears any liability for costs or damages as a result of such lawsuit LICENSEE shall be entitled to deposit one-half (1/2) of the royalty payments to be paid to PRF under Paragraph 4.2 hereof into said Escrow Account. The other one-half (1/2) of the royalty payments required to be paid under Paragraph 4.2 hereof shall continue to be paid to PRF under the terms of this Agreement. If no royalty payments are yet due PRF during the period of the defense of any such alleged infringement, LICENSEE shall be entitled to accrue a credit for all sums expended to pay any costs and to pay any damages which may be awarded for infringement, and to offset these expenditures against any royalties to be paid to PRF.

				

		
			  
		

		
			 
		

		
			The amounts deposited into the Escrow Account shall be used to pay LICENSEE’s out-of-pocket monetary expenses actually incurred in defending the lawsuit, including attorneys’ fees and any damages assessed against Defendant based specifically and only on Defendant’s manufacture, use or sale of Licensed Products. The Escrow account shall be established as a Federally Insured deposit account earning interest not less than money market or equivalent rates. The agreement establishing the Escrow Account shall require the Escrow Agent to provide PRF and LICENSEE with accurate accounting reports, to reimburse LICENSEE for its said expenses as approved in writing by PRF, and to remit to PRF any balance left in said account immediately all costs have been paid and all damage awards have been satisfied. PRF shall approve all of out-of-pocket expenses for reimbursement by the Escrow Agent provided the expenses are accurately documented for PRF and shown to be reasonably necessary to the defense of the lawsuit or an actual payment of assessed damages. LICENSEE shall have no recourse against PRF concerning such a lawsuit other than the provisions of this Section 7.4.
		

		
			 
		

		
			ARTICLE VIII — PRODUCT LIABILITY
		

		
			 
		

			
					
						 

					
					
						8.1

					
					
						LICENSEE shall indemnify and save PRF and/or Purdue University harmless from any and all claims, demands, actions and causes of action against, PRF whether groundless or not, in connection with any and all injuries, losses, damages or liability of any kind whatsoever arising, directly or indirectly, out of use, distribution, or sale of Licensed Products by or through the LICENSEE or its Affiliates or sublicensees whether or not the claims, demands, actions or causes of action are alleged to have resulted in whole or in part from the negligent acts or omissions of PRF and/or Purdue University or from acts or omissions of such persons for which they are or any of them would otherwise be strictly liable. This indemnification obligation shall include, without limiting the generality of the foregoing, reasonable attorney fees and other costs or expenses incurred in connection with the defense of any and all such claims, demands, actions, or causes of action, and shall extend to the Trustees, officers, employees, and agents of PRF and/or Purdue University. This indemnification obligation does not extend to any occurrences or events whether at the PRF’s or Purdue University’s facilities or elsewhere except those occurring in connection with the use, distribution, or sale of Licensed Products by or through LICENSEE, or its Affiliates.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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						8.2

					
					
						LICENSEE shall obtain and carry in full force and effect liability insurance which shall protect LICENSEE and PRF in regard to the events covered by Section 8.1 herein. LICENSEE shall name PRF as an additional name insured on said liability insurance. The policy of said liability insurance shall require written notice of termination to be provided to PRF at least thirty (30) days prior to expiration or other cancellation thereof.

				

		
			 
		

			
					
						 

					
					
						8.3

					
					
						PRF hereby warrants that as of the Effective Date, it is aware of no fact which places the validity of the Patents into question. Further, PRF hereby warrants that as of the Effective Date, it is unaware of any patent or claim by any third party upon the basis of which PRF has any reason to believe that the making, using or selling of any Licensed Product will infringe any valid United States patent.

				

		
			 
		

			
					
						 

					
					
						8.4

					
					
						EXCEPT TO THE EXTENT EXPRESSLY STATED TO THE CONTRARY IN THIS AGREEMENT, PRF SHALL NOT BE DEEMED TO HAVE MADE ANY REPRESENTATION OR WARRANTY, EXPRESS OR IMPLIED, AS TO THE CONDITION, MERCHANTABILITY, DESIGN, OPERATION OR FITNESS FOR USE OF LICENSED PRODUCTS OR ANY OTHER REPRESENTATION OR WARRANTY WHATSOEVER, EXPRESS OR IMPLIED, WITH RESPECT TO LICENSED PRODUCTS OR LICENSED PATENTS. PRF EXPRESSLY MAKES NO WARRANTY OF VALIDITY OF PATENTS LICENSED HEREUNDER.

				

		
			 
		

		
			ARTICLE IX — EXPORT CONTROLS
		

		
			 
		

			
					
						 

					
					
						9.1

					
					
						It is understood that PRF is subject to United States laws and regulations controlling the export of technical data, computer software, laboratory prototypes and other commodities (including the Arms Export Control Act, as amended and the Export Administration Act of 1979), and that its obligations hereunder are contingent on compliance with applicable United States export laws and regulations. The transfer of certain technical data and commodities may require a license from the cognizant agency of the United States Government and/or written assurances by LICENSEE that LICENSEE shall not export data or commodities to certain foreign countries without prior approval of such agency. PRF neither represents that a license shall not be required nor that, if required, it shall be issued.

				

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange  Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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			ARTICLE X — NON-USE OF NAMES
		

		
			 
		

			
					
						 

					
					
						10.1

					
					
						LICENSEE shall not use the names of the Purdue Research Foundation nor Purdue University nor any of its employees, nor any adaptation thereof, in any advertising, promotional or sales literature without prior written consent obtained from PRF in each case, except that LICENSEE may state that it is licensed by PRF under one or more of the Patents and/or applications comprising the Patents.

				

		
			  
		

			
					
						 

					
					
						10.2

					
					
						LICENSEE agrees that it will not under any circumstances advertise or otherwise state or imply that PRF or Purdue University has tested or approved any product or process.

				

		
			 
		

		
			ARTICLE XI — ASSIGNMENT
		

		
			 
		

			
					
						 

					
					
						11.1

					
					
						This Agreement shall inure to the benefit of and be binding upon the Parties hereto, their successors and permitted assigns. LICENSEE shall be permitted to assign its rights and obligations under this Agreement upon the written consent of PRF, which shall not be unreasonably withheld.

				

		
			 
		

		
			ARTICLE XII — TERMINATION
		

		
			 
		

			
					
						 

					
					
						12.1

					
					
						If LICENSEE shall be in default of any material obligation hereunder, and shall fail to remedy such default within ninety (90) days after notice thereof by PRF, this Agreement may be terminated at the option of PRF by notice to that effect.

				

		
			 
		

			
					
						 

					
					
						12.2

					
					
						LICENSEE shall have the right to terminate this Agreement at any time by giving notice in writing to PRF of its intent to do so at least sixty (60) days prior to a termination date designated in said notice. In the event this Agreement is terminated pursuant to this paragraph 12.2, LICENSEE must pay PRF, not later than sixty (60) days after said designated termination, any royalties due under Article IV prior to the designated termination date.

				

		
			 
		

			
					
						 

					
					
						12.3

					
					
						In the event of any termination under this Article, LICENSEE shall, at PRF’s request, assign its rights under any sublicense agreement hereunder to PRF.

				

		
			 
		

			
					
						 

					
					
						12.4

					
					
						Unless otherwise terminated as provided herein, this Agreement shall remain in full force and effect until the expiration of the last-to-expire of the Valid Claim or Claims.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
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						12.5

					
					
						This License Agreement shall be voidable by PRF in the event LICENSEE files bankruptcy.

				

		
			 
		

		
			ARTICLE XIII — PAYMENTS, NOTICES, AND OTHER COMMUNICATIONS
		

		
			 
		

			
					
						 

					
					
						13.1

					
					
						Service of all notices or reports provided for herein shall be deemed duly given if sent by registered or certified mail, postage prepaid, to the addresses below. The date of mailing shall be the date of such notice.

				

		
			 
		

		
			 
		

			
					
						LICENSEE:

					
					
						President

				
	
					
						   

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						1205 Kent Avenue

				
	
					
						 

					
					
						West Lafayette, Indiana 47906

				
	
					
						 

					
					
						 

				
	
					
						PRF:

					
					
						Office of Technology Transfer (P-88080)

				
	
					
						 

					
					
						Purdue Research Foundation

				
	
					
						 

					
					
						1063 Hovde Hall, Room 300

				
	
					
						 

					
					
						West Lafayette, IN 47907-1063

				

		
			 
		

			
					
						 

					
					
						13.2

					
					
						LICENSEE agrees to give PRF reasonable notice of all management meetings to be held by LICENSEE involving the Licensed Products and will permit PRF to attend all such meetings.

				

		
			 
		

		
			ARTICLE XIV — GENERAL
		

		
			 
		

			
					
						 

					
					
						14.1

					
					
						PRF warrants and represents that as of the date of this Agreement it is the exclusive and sole owner of the Patents and that PRF has the right to make the conveyances set forth herein.

				

		
			 
		

			
					
						 

					
					
						14.2

					
					
						LICENSEE shall mark the Licensed Products in accordance with 35 U.S.C. 287 and shall require same of any Affiliates or sublicensees.

				

		
			 
		

			
					
						 

					
					
						14.3

					
					
						PRF shall not be liable to LICENSEE for failure by LICENSEE to obtain profit or income from Licensed Products.

				

		
			 
		

			
					
						 

					
					
						14.3

					
					
						This Agreement shall be construed according to the laws of the State of Indiana. It constitutes the entire agreement between the Parties hereto with respect to the subject matter hereof and may not be modified or extended except by written document signed by an executive officer of the Parties.

				

		
			 
		

			
					
						 

					
					
						14.4

					
					
						IN WITNESS WHEREOF, the Parties hereto have caused this instrument to be executed by their duly authorized officers as of the day and year first above written.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  11  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						PURDUE RESEARCH FOUNDATION

					
					
						 

					
					
						ENDOCYTE CORPORATION

					
					
						 

				
	
					
						(PRF)

					
					
						 

					
					
						(LICENSEE)

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						/s/ William E. Baitinger

					
					
						 

					
					
						/s/ P. Ron Ellis

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Signature

					
					
						 

					
					
						Signature

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						William E. Baitinger
Senior Technology Mgr.

					
					
						 

					
					
						P. Ron Ellis

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Typed Name

					
					
						 

					
					
						Typed Name

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						President and CEO

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Title

					
					
						 

					
					
						Title

					
					
						 

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  12  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			APPENDIX A
		

		
			 
		

		
			United States Patents Granted and Applications Pending
		

		
			 
		

			
					
						Purdue

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Reference

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						Issue/Filing

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Number

					
					
						 

					
					
						Matter #

					
					
						 

					
					
						Serial #

					
					
						 

					
					
						Date

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.US

					
					
						 

					
					
						20035

					
					
						 

					
					
						07/498,762

					
					
						 

					
					
						3/28/90
4/28/92

					
					
						 

					
					
						Method of Enhanced Transmembrane Transport of Exogenous Molecules (continuation of P-88080 now abandoned) (biotin, riboflavin)

					
					
						 

					
					
						(CIP of 07/331,816, 4/30/89 ABAN) Patent No. 5,108,921;
Expires 4/28/2009

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.20.US

					
					
						 

					
					
						21712

					
					
						 

					
					
						07/851,544

					
					
						 

					
					
						3/13/92
5/16/95

					
					
						 

					
					
						Method of Enhanced Transmembrane Transport of Exogenous Molecules (folate)

					
					
						 

					
					
						U.S. Patent No. 5,416,016
Expires 5/16/2012

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.30.US

					
					
						 

					
					
						25043

					
					
						 

					
					
						08/349,407

					
					
						 

					
					
						12/05/94
6/3/97

					
					
						 

					
					
						Method of Enhanced Transmembrane Transport of Exogenous Molecules (thiamin)

					
					
						 

					
					
						U.S. Patent No. 5,635,382
Expires 12/5/2014

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.3A.US

					
					
						 

					
					
						28035

					
					
						 

					
					
						08/784,019

					
					
						 

					
					
						1/15/97
10/13/98

					
					
						 

					
					
						Method for Targeting a Diagnostic Agent to Cells (no transmembrane transport required)

					
					
						 

					
					
						U.S. Patent No. 5,820,847
Expires 1/15/2017

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.40.US

					
					
						 

					
					
						25124

					
					
						 

					
					
						08/442,174

					
					
						 

					
					
						5/16/95
11/18/97

					
					
						 

					
					
						Composition and Method for Tumor Imaging

					
					
						 

					
					
						U.S. Patent No. 5,688,488
Expires 5/16/2015

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-96114.00.US

					
					
						 

					
					
						62306

					
					
						 

					
					
						N/A

					
					
						 

					
					
						10/16/98

					
					
						 

					
					
						Folic Acid Derivatives

					
					
						 

					
					
						U.S. Nationalized PCT filed 4/17/00

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						—

					
					
						 

					
					
						 

					
					
						 

					
					
						Provisional Filed

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						Purdue

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Reference

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						Issue/Filing

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Number

					
					
						 

					
					
						Matter #

					
					
						 

					
					
						Serial #

					
					
						 

					
					
						Date

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-99072.P1.US

					
					
						 

					
					
						65007

					
					
						 

					
					
						N/A

					
					
						 

					
					
						3/31/00

					
					
						 

					
					
						Method of Treatment Using Lignad-Immunogen Conjugates

					
					
						 

					
					
						 

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  2  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			U.S. Parent: Matter No. 20035 (P-88080.1), U.S. Patent 5,108,921
		

		
			 
		

		
			FOREIGN COUNTERPARTS
		

		
			 
		

			
					
						Purdue Ref. #

					
					
						 

					
					
						Matter#

					
					
						 

					
					
						Application No.

					
					
						 

					
					
						Country Filed

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.EP

					
					
						 

					
					
						21407

					
					
						 

					
					
						90906542.7-21

					
					
						 

					
					
						E.P.C.

					
					
						 

					
					
						Application published 1/22/92 as Publication No. 0466816; Application granted 11/26/97
Claims directed to biotin and folate

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.JP

					
					
						 

					
					
						21408

					
					
						 

					
					
						2-506140

					
					
						 

					
					
						Japan

					
					
						 

					
					
						Application filed: 4/2/90
Requested Exam 3/13/97 claims conformed to EPO

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.IE

					
					
						 

					
					
						20070

					
					
						 

					
					
						1201/90

					
					
						 

					
					
						Ireland

					
					
						 

					
					
						Application filed: 4/3/90
Copy of EPO granted application filed

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.CA

					
					
						 

					
					
						20071

					
					
						 

					
					
						2013582-4

					
					
						 

					
					
						Canada

					
					
						 

					
					
						Application filed: 4/2/90
Requested Exam 3/13/97 claims conformed to EPO

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.IL

					
					
						 

					
					
						20072

					
					
						 

					
					
						93983

					
					
						 

					
					
						Israel

					
					
						 

					
					
						Application filed: 4/2/90
Application issued May 19, 1997
Expires 4/2/2010

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.ZA

					
					
						 

					
					
						20073

					
					
						 

					
					
						90/2538

					
					
						 

					
					
						South Africa

					
					
						 

					
					
						Patent Issued: 1/30/91
Patent No. 90/2538
Expires April 3, 2010

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						20080

					
					
						 

					
					
						—

					
					
						 

					
					
						Singapore

					
					
						 

					
					
						Application abandoned November 11, 1997

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  3  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						Purdue Ref #

					
					
						 

					
					
						Matter#

					
					
						 

					
					
						Application No.

					
					
						 

					
					
						Country Filed

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.AT

					
					
						 

					
					
						28833

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Austria

					
					
						 

					
					
						Issued 11/26/97
Patent No. ATE 160583T

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.BE

					
					
						 

					
					
						28834

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Belgium

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.CH

					
					
						 

					
					
						28835

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Switzerland

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.DE

					
					
						 

					
					
						28836

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Germany

					
					
						 

					
					
						Issued 11/26/97
Patent No. 69031763.8

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.DK

					
					
						 

					
					
						28837

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Denmark

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.ES

					
					
						 

					
					
						28838

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Spain

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.FR

					
					
						 

					
					
						28839

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						France

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.GB

					
					
						 

					
					
						28840

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Great Britain

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.IT

					
					
						 

					
					
						28841

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Italy

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  4  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			U.S. Parent: Matter No. 20035 (P-88080.1), U.S. Patent 5,108,921
		

		
			 
		

		
			FOREIGN COUNTERPARTS
		

		
			 
		

			
					
						Purdue Ref #

					
					
						 

					
					
						Matter#

					
					
						 

					
					
						Application No.

					
					
						 

					
					
						Country Filed

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.LU

					
					
						 

					
					
						28842

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Luxemburg

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.NL

					
					
						 

					
					
						28843

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Netherlands

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.10.SE

					
					
						 

					
					
						28844

					
					
						 

					
					
						90906542.7-2105

					
					
						 

					
					
						Sweden

					
					
						 

					
					
						Issued 11/26/97
Patent No. 0466816

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  5  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			U.S. Parent: Matter No. 25124 (P-94096), U.S. Patent No. 5,688,488
		

		
			 
		

		
			FOREIGN COUNTERPARTS
		

		
			 
		

			
					
						Purdue Ref #

					
					
						 

					
					
						Matter#

					
					
						 

					
					
						Application No.

					
					
						 

					
					
						Country Filed

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-94096.00.WO

					
					
						 

					
					
						26855

					
					
						 

					
					
						PCT/US96/07002

					
					
						 

					
					
						PCT

					
					
						 

					
					
						Abandoned in favor of
national applications

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-94096.00.CA

					
					
						 

					
					
						29190

					
					
						 

					
					
						2220008

					
					
						 

					
					
						Canada

					
					
						 

					
					
						Application filed 5/16/96
Request for Exam filed 3/97

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-94096.00.EP

					
					
						 

					
					
						29191

					
					
						 

					
					
						96916476.3

					
					
						 

					
					
						E.P.C.

					
					
						 

					
					
						Application filed 5/16/96

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-94096.00.JP

					
					
						 

					
					
						29192

					
					
						 

					
					
						08-535034

					
					
						 

					
					
						Japan

					
					
						 

					
					
						Application filed: 5/16/96
Request for Exam filed 3/97

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  6  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			APPENDIX B
		

		
			 
		

		
			EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AGREEMENT is entered on this 17 th day of July, 1998 and shall be effective as of the 21 st day of December, 1995 (“Effective Date”) by and between PURDUE RESEARCH FOUNDATION, a corporation of Indiana having an address at West Lafayette, Indiana 47907 (hereinafter “PRF”), and Endocyte Corporation, an Indiana corporation, having a place of business at Lafayette, Indiana (hereinafter “LICENSEE”), PRF and LICENSEE collectively referred to hereinafter as “the Parties.”
		

		
			 
		

		
			WITNESSETH:
		

		
			 
		

		
			WHEREAS, PRF is the owner by assignment of those United States Patents and corresponding patents in other countries all as set forth in Appendix A attached hereto (hereinafter, together with all divisions, continuations, continuations-in-part, foreign counterparts, and reissues thereof, called the “Patents”); and
		

		
			 
		

		
			WHEREAS, PRF and LICENSEE have previously executed an Exclusive License Agreement (Appendix B), dated December 2, 1996. LICENSEE and PRF agree that the terms and conditions of this Exclusive License Agreement shall supercede and take precedence over the previous Exclusive License Agreement (Appendix B) issued on December 2, 1996.
		

		
			 
		

		
			WHEREAS, LICENSEE desires expanded license rights under such Patents and PRF is willing to grant such license rights under the terms and conditions hereinafter set forth;
		

		
			 
		

		
			NOW, THEREFORE, in consideration of the mutual promises and undertakings hereinafter set forth, the Parties hereto agree as follows:
		

		
			 
		

		
			ARTICLE I — DEFINITIONS
		

		
			 
		

		
			As used herein, the following terms shall have the following meanings:
		

		
			 
		

			
					
						 

					
					
						1.1

					
					
						“Affiliate” shall mean a corporation, company, partnership, or other business entity which controls or is controlled by, or is under common control with, the designated party. In the case of a corporation or company, “control” means ownership either directly or indirectly of at least fifty percent (50%) of the shares of stock entitled to vote for the election of directors. The term “Affiliate” shall not include a third-party sublicensee of LICENSEE.

				

		
			 
		

			
					
						 

					
					
						1.2

					
					
						“FDA Approval” shall mean final approval from the United States Food and Drug Administration to distribute, market and sell any Licensed Product in the United States.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						 

					
					
						1.3

					
					
						“Licensed Products” shall mean products falling within the scope of a Valid Claim or claims of the Patents or made by processes within the scope of a Valid Claim or claims of the Patents.

				

		
			 
		

			
					
						 

					
					
						1.4

					
					
						“Sales Value” shall mean (i) in the case of Licensed Products used by LICENSEE or its Affiliates, the list price thereof for sales to third parties; (ii) in the case of Licensed Products sold to third parties, the invoice price, F.O.B place of manufacture, exclusive of sales taxes, packing, shipping and insurance charges, and less returns, allowances, and discounts actually allowed; and (iii) in the case of any use of any Licensed Product by LICENSEE, any Affiliate or any third party for the purpose of any testing or studies necessary to obtain FDA Approval, Zero Dollars ($0.00).

				

		
			 
		

			
					
						 

					
					
						1.5

					
					
						“Valid Claim” shall mean any claim contained in any pending patent application or issued patent included within the Patents which has not been abandoned or declared invalid in a non-appealable order, as the case may be, and which would be infringed by the manufacture, use or sale of Licensed Products in the absence of the licenses granted hereunder.

				

		
			 
		

			
					
						 

					
					
						1.6

					
					
						“Territory” shall mean all countries, worldwide.

				

		
			 
		

			
					
						 

					
					
						1.7

					
					
						“Field of Use” shall mean:

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						All Diagnostic and Imaging Applications; and

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						All Therapeutic Applications.

				

		
			 
		

			
					
						 

					
					
						1.8

					
					
						“Therapeutic Applications” shall mean any use of a Licensed Product for the curative treatment or healing of disease or injury.

				

		
			 
		

			
					
						 

					
					
						1.9

					
					
						“Diagnostic or Imaging Applications” shall mean any use of a Licensed Product for purposes of the investigation or determination of the nature or extent of any disease or injury.

				

		
			 
		

		
			ARTICLE II — GRANTS
		

		
			 
		

			
					
						 

					
					
						2.1

					
					
						PRF grants, subject to the terms of this Agreement, to LICENSEE a royalty-bearing, exclusive license under the Patents to make, to have made, use and sell Licensed Products in the Field of Use in the Territory.

				

		
			 
		

		
			     2.2  LICENSEE shall have the right to grant sublicenses under the license granted herein, and to extend the sublicenses to any third party  
		

		
			          or Affiliate of LICENSEE.
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  2  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			LICENSEE shall notify PRF promptly of any grant of sublicense hereunder and the terms thereof.
		

		
			 
		

			
					
						 

					
					
						2.3

					
					
						PRF shall reserve, and the license granted shall be subject to the royalty-free right in PRF (or in Purdue University, if PRF’s rights are assigned to the University) to make or have made for its use (but not to sell) the products or devices (or the rights to practice the process, if a process invention) under each patent, provided that such reserved rights shall be used by PRF (or the University as the case may be) solely for educational and research purposes and not for commercial purposes.

				

		
			 
		

			
					
						 

					
					
						2.4

					
					
						All rights reserved to the United States Government and others under Public Law 96-517 and 98-620 shall remain and shall in no way be affected by this Agreement. Portions of the Patents were developed under Grant 89-45-DC8-88-11465 awarded by the National Science Foundation.

				

		
			 
		

			
					
						 

					
					
						2.5

					
					
						PRF hereby warrants that it is the owner of the Patents and that such Patents are not subject to any lien, encumbrance, license or claim of ownership of any third party, except to the extent stated in Section 2.4, in derogation of the rights granted to LICENSEE in this Agreement.

				

		
			 
		

		
			ARTICLE III — DUE DILIGENCE
		

		
			 
		

			
					
						 

					
					
						3.1

					
					
						(a) LICENSEE shall use its best efforts to bring one or more Licensed Products in the Field of Use to market through a thorough, vigorous and diligent program for exploitation of Patents. LICENSEE shall supply to PRF a business and project plan for the Licensed Products to PRF no later than twelve (12) months after the Effective Date.

				

		
			 
		

		
			(b) LICENSEE further agrees to secure $[*] to be expended for the testing and development of the Licensed Products. Once this initial funding of $[*] has been expended (the “Crossover Date”), LICENSEE shall provide evidence of obtaining Additional Support needed to develop the technology. Additional support shall be defined as:
		

		
			 
		

			
					
						 

					
					
						(I)

					
					
						Having secured additional funding of at least $[*]; or

				

		
			 
		

			
					
						 

					
					
						(II)

					
					
						Enter into a venture for the development and commercialization of the Diagnostic Imaging and Therapeutic applications of the Licensed Products.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  3  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			If after 24 months after the Crossover Date the LICENSEE has not provided evidence of Additional Support, this Agreement may be terminated on written notice of PRF.
		

		
			 
		

		
			(d) LICENSEE further agrees to begin the development of Therapeutic Applications of the Licensed Products, other than those involving Gene Therapy, no later than eighteen months from the Effective Date.
		

		
			 
		

		
			(e) LICENSEE further agrees to provide evidence of being in bona fide negotiations or in-house development for Gene Therapy applications no later than thirty-six (36) months from the Effective Date.
		

		
			 
		

		
			(f) LICENSEE further agrees to provide $[*] over a three year period from Effective Date to fund research at Purdue University.
		

		
			 
		

			
					
						 

					
					
						3.2

					
					
						It at any time following twenty-four (24) months following FDA Approval, PRF is of the opinion that LICENSEE is not meeting the public demand for Licensed Products, PRF shall notify LICENSEE to that effect and LICENSEE shall have six (6) months after such notice within which to meet such demand or to make other arrangements satisfactory to PRF. If at the end of six (6) months’ period PRF is not satisfied that the public demand is or will be reasonably met by LICENSEE, PRF may, at its option, terminate the license or convert the exclusive license to a non-exclusive license upon sixty (60) days’ notice to LICENSEE. Net sales, based upon Sales Value, of [*] or more of the Licensed Products by LICENSEE and any sublicensees during the first twenty-four (24) months following FDA Approval shall be regarded by PRF as meeting the public demand. Public demand is defined as having the product/process available in quantities sufficient to satisfy the needs of the public at a reasonable cost.

				

		
			 
		

		
			ARTICLE IV — PRF ROYALTY OBLIGATIONS
		

		
			 
		

			
					
						 

					
					
						4.1

					
					
						LICENSEE shall pay PRF licensing fees according to the following schedule:

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						$[*] on the Effective Date;

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						$[*] six months after the Effective Date;

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						$[*] twelve months after the Effective Date;

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						$[*] eighteen months after the Effective Date; and

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						$[*] twenty-four months after the Effective Date.

				

		
			 
		

			
					
						 

					
					
						4.2

					
					
						Subject to all the terms and conditions of this Agreement, for each calendar year this Agreement is in effect, LICENSEE shall pay to PRF an earned royalty, which shall be agreed to in writing by the parties and which shall not exceed the maximum percentages set forth below, calculated as a percentage of the Sales Value of Licensed Products used or sold by LICENSEE, it sublicensees or its Affiliates in the Territory during such calendar year. The maximum royalty percentages shall be:

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  4  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						 

					
					
						(a)

					
					
						[*] for Therapeutic Applications

				

		
			 
		

			
					
						 

					
					
						(b)

					
					
						[*] for Diagnostic and Imaging Applications

				

		
			 
		

		
			At any time during the term of this Agreement, the parties shall be free to renegotiate, in good faith, the earned royalty percentages previously agreed to; provided that, in no event shall the renegotiated royalty percentages exceed the maximum royalty percentages set forth above.
		

		
			 
		

			
					
						 

					
					
						4.3

					
					
						LICENSEE shall pay to PRF an annual minimum royalty for each calendar year during the life of this Agreement beginning in calendar year 1998. The minimum royalty shall be payable on or before December 31 of each such calendar year. The minimum royalties shall be as follows:

				

		
			 
		

			
					
						2002

					
					
						 

					
					
						$

					
5,000
					
					
						 

				
	
					
						2003

					
					
						 

					
					
						$

					
7,500
					
					
						 

				
	
					
						2004

					
					
						 

					
					
						$

					
10,000
					
					
						 

				
	
					
						2005

					
					
						 

					
					
						$

					
12,500
					
					
						 

				
	
					
						Each year thereafter

					
					
						 

					
					
						$

					
12,500
					
					
						 

				

		
			 
		

		
			If earned royalties for any calendar year do not equal or exceed the minimum royalty owed for that calendar year, LICENSEE shall pay PRF an amount equal to the difference between the calendar year earned royalty and the calendar year minimum royalty, said amount payable on or before January 31 of the next following calendar year.
		

		
			 
		

		
			ARTICLE V — RECORDS, REPORTS, PAYMENTS
		

		
			 
		

			
					
						 

					
					
						5.1

					
					
						LICENSEE shall keep accurate books and records showing all sales and use by LICENSEE and its sublicensee of Licensed Products, together with such other information as shall be necessary to enable earned royalties to be computed, and on or before the last day of March, June, September, and December of each year during the life of this Agreement. LICENSEE shall render to PRF a written report showing the calculation, in reasonable detail, of earned royalty for the preceding calendar quarter and shall accompany each such report with payment of any amount shown to be due. Such reports are to be made by LICENSEE whether or not royalties are owed. Such reports and any royalties due will be made to PRF within thirty (30) days of the end of each calendar quarter. LICENSEE’s records and books shall be open during reasonable business hours for reasonable inspection by a certified public accountant appointed and paid for by PRF and reasonably acceptable to LICENSEE, to determine the accuracy of such royalty statements and payments but for not other purpose. PRF agrees that it and its designees shall keep confidential and shall not disclose or use for purposes other than those set forth in Section 5.1, any information, report or document provided to or made available to PRF or its designee.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  5  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			ARTICLE VI — PATENT PROSECUTION
		

		
			 
		

			
					
						 

					
					
						6.1

					
					
						PRF shall apply for and seek issuance of Patents and shall maintain the Patents for the duration of the term of the Patents during the term of this Agreement. The prosecution, filing and maintenance of all Patents shall be the primary responsibility of PRF; provided, however, LICENSEE shall have reasonable opportunities to advise PRF and shall cooperate with PRF in such prosecution, filing, and maintenance. PRF shall promptly provide LICENSEE copies of all notices and correspondence to or from the U.S .Patent and Trademark Office and any foreign patent offices.

				

		
			 
		

			
					
						 

					
					
						6.2

					
					
						Payment of all fees and costs relating to the filing, prosecution, and maintenance of the Patents shall be the responsibility of LICENSEE, whether or not such fees and costs were incurred before or after the date of this Agreement. PRF acknowledges receipt of patent expenses in the amount of $209,705.41 (see Appendix C) which covers all prior patent expenses through April 30, 1998.

				

		
			 
		

		
			ARTICLE VII — INFRINGEMENT/ENFORCEMENT
		

		
			 
		

			
					
						 

					
					
						7.1

					
					
						If during the term of this Agreement one ore more Patents licensed hereunder is or appears to be infringed by a third party within the Field of Use, then the party having knowledge thereof shall notify the other and the parties shall consult to consider what, if any, action should be taken. Under no circumstances shall PRF have the obligation to enforce Patents. LICENSEE shall have the first right (but not the obligation) to notify the infringer and/or initiate litigation or legal proceedings to abate the infringement, with the prior consent of PRF. PRF may elect to join in any such legal proceedings against the alleged infringer. In the event LICENSEE has not initiated such legal proceedings within six (6) months after becoming aware of the infringement, then PRF may initiate such legal proceedings on its own behalf; and thereafter, LICENSEE may elect to join in those proceedings.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  6  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						 

					
					
						7.2

					
					
						If PRF elects to join in legal proceedings commenced by LICENSEE, or if LICENSEE elected to join in legal proceedings commanded by PRF, all fees and costs incurred therein, and all damages shall be the responsibility of PRF. If one Party elects not to join in legal proceedings initiated by the other Party, then the initiating Party shall be responsible for all fees and costs incurred therein. All reasonable costs and expenses incurred as a result of said legal proceedings shall be recoverable by LICENSEE out of damages and awards recovered by LICENSEE and/or PRF. Any remaining amounts from damages and awards, once costs and expenses have been recovered, shall be divided equally between LICENSEE and PRF. Each Party shall reasonably cooperate with the other Party, whether joining or not, in the conduct of the proceedings (such as by joining in name only); however, where PRF is joined in any such legal proceedings in name only as a necessary party and not at its election, then LICENSEE shall indemnify and hold harmless PRF from and against any and all actions, claims, and counterclaims brought against PRF, and LICENSEE agrees to pay all legal expenses, damages, and costs which may be finally assessed against PRF in such actions, claims, and counterclaims.

				

		
			 
		

			
					
						 

					
					
						7.3

					
					
						PRF makes no warranty that the subject matter of the invention licensed hereunder will not infringe any third party patent and PRF makes no covenant either to defend any infringement charge by a third party or to institute action against infringers of any Patents hereby licensed.

				

		
			 
		

			
					
						 

					
					
						7.4

					
					
						If LICENSEE, any sublicensee or customer is named as a defendant in a lawsuit (hereinafter “Defendant”) charging Defendant with patent infringement as a result of its manufacture or sale of Licensed Products or its use of Licensed Products as disclosed in Patents or otherwise contending that Defendant does not have the right to manufacture, sell or so use Licensed Products, and LICENSEE so notifies PRF that such a lawsuit has been filed and provides PRF with copies of the Complaint and all papers associated with its filing. LICENSEE shall have the right to establish an Escrow Account for the mutual benefit of PRF and LICENSEE. For so long as LICENSEE bears any liability for costs or damages as a result of such lawsuit LICENSEE shall be entitled to deposit one-half (1/2) of the royalty payments to be paid to PRF under Paragraph 4.2 hereof into said Escrow Account. The other one-half (1/2) of the royalty payments required to be paid under Paragraph 4.2 hereof shall continue to be paid to PRF under the terms of this Agreement. If no royalty payments are yet due PRF during the period of the defense of any such alleged infringement, LICENSEE shall be entitled to accrue a credit for all sums expended to pay any costs and to pay any damages which may be awarded for infringement, and to offset these expenditures against any royalties to be paid to PRF.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  7  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			The amounts deposited into the Escrow Account shall be used to pay LICENSEE’s out-of-pocket monetary expenses actually incurred in defending the lawsuit, including attorneys’ fees and any damages assessed against Defendant based specifically and only on Defendant’s manufacture, use or sale of Licensed Products. The Escrow account shall be established as a Federally Insured deposit account earning interest not less than money market or equivalent rates. The agreement establishing the Escrow Account shall require the Escrow Agent to provide PRF and LICENSEE with accurate accounting reports, to reimburse LICENSEE for its said expenses as approved in writing by PRF, and to remit to PRF any balance left in said account immediately all costs have been paid and all damage awards have been satisfied. PRF shall approve all of out-of-pocket expenses for reimbursement by the Escrow Agent provided the expenses are accurately documented for PRF and shown to be reasonably necessary to the defense of the lawsuit or an actual payment of assessed damages. LICENSEE shall have no recourse against PRF concerning such a lawsuit other than the provisions of this Section 7.4.
		

		
			 
		

		
			ARTICLE VIII — PRODUCT LIABILITY
		

		
			 
		

			
					
						 

					
					
						8.1

					
					
						LICENSEE shall indemnify and save PRF and/or Purdue University harmless from any and all claims, demands, actions and causes of action against, PRF whether groundless or not, in connection with any and all injuries, losses, damages or liability of any kind whatsoever arising, directly or indirectly, out of use, distribution, or sale of Licensed Products by or through the LICENSEE or its Affiliates or sublicensees whether or not the claims, demands, actions or causes of action are alleged to have resulted in whole or in part from the negligent acts or omissions of PRF and/or Purdue University or from acts or omissions of such persons for which they are or any of them would otherwise be strictly liable. This indemnification obligation shall include, without limiting the generality of the foregoing, reasonable attorney fees and other costs or expenses incurred in connection with the defense of any and all such claims, demands, actions, or causes of action, and shall extend to the Trustees, officers, employees, and agents of PRF and/or Purdue University. This indemnification obligation does not extend to any occurrences or events whether at the PRF’s or Purdue University’s facilities or elsewhere except those occurring in connection with the use, distribution, or sale of Licensed Products by or through LICENSEE, or its Affiliates.

				

		
			 
		

			
					
						 

					
					
						8.2

					
					
						LICENSEE shall obtain and carry in full force and effect liability insurance which shall protect LICENSEE and PRF in regard to the events covered by Section 8.1 herein. LICENSEE shall name PRF as an additional name insured on said liability insurance. The policy of said liability insurance shall require written notice of termination to be provided to PRF at least thirty (30) days prior to expiration or other cancellation thereof.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  8  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						 

					
					
						8.3

					
					
						PRF hereby warrants that as of the Effective Date, it is aware of no fact which places the validity of the Patents into question. Further, PRF hereby warrants that as of the Effective Date, it is unaware of any patent or claim by any third party upon the basis of which PRF has any reason to believe that the making, using or selling of any Licensed Product will infringe any valid United States patent.

				

		
			 
		

			
					
						 

					
					
						8.4

					
					
						EXCEPT TO THE EXTENT EXPRESSLY STATED TO THE CONTRARY IN THIS AGREEMENT, PRF SHALL NOT BE DEEMED TO HAVE MADE ANY REPRESENTATION OR WARRANTY, EXPRESS OR IMPLIED, AS TO THE CONDITION, MERCHANTABILITY, DESIGN, OPERATION OR FITNESS FOR USE OF LICENSED PRODUCTS OR ANY OTHER REPRESENTATION OR WARRANTY WHATSOEVER, EXPRESS OR IMPLIED, WITH RESPECT TO LICENSED PRODUCTS OR LICENSED PATENTS. PRF EXPRESSLY MAKES NO WARRANTY OF VALIDITY OF PATENTS LICENSED HEREUNDER.

				

		
			 
		

		
			ARTICLE IX — EXPORT CONTROLS
		

		
			 
		

			
					
						 

					
					
						9.1

					
					
						It is understood that PRF is subject to United States laws and regulations controlling the export of technical data, computer software, laboratory prototypes and other commodities (including the Arms Export Control Act, as amended and the Export Administration Act of 1979), and that its obligations hereunder are contingent on compliance with applicable United States export laws and regulations. The transfer of certain technical data and commodities may require a license from the cognizant agency of the United States Government and/or written assurances by LICENSEE that LICENSEE shall not export data or commodities to certain foreign countries without prior approval of such agency. PRF neither represents that a license shall not be required nor that, if required, it shall be issued.

				

		
			 
		

		
			ARTICLE X — NON-USE OF NAMES
		

		
			 
		

			
					
						 

					
					
						10.1

					
					
						LICENSEE shall not use the names of the Purdue Research Foundation nor Purdue University nor any of its employees, nor any adaptation thereof, in any advertising, promotional or sales literature without prior written consent obtained from PRF in each case, except that LICENSEE may state that it is licensed by PRF under one or more of the Patents and/or applications comprising the Patents.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  9  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						 

					
					
						10.2

					
					
						LICENSEE agrees that it will not under any circumstances advertise or otherwise state or imply that PRF or Purdue University has tested or approved any product or process.

				

		
			 
		

		
			ARTICLE XI — ASSIGNMENT
		

		
			 
		

			
					
						 

					
					
						11.1

					
					
						This Agreement shall inure to the benefit of and be binding upon the Parties hereto, their successors and permitted assigns. LICENSEE shall be permitted to assign its rights and obligations under this Agreement upon the written consent of PRF, which shall not be unreasonably withheld.

				

		
			 
		

		
			ARTICLE XII — TERMINATION
		

		
			 
		

			
					
						 

					
					
						12.1

					
					
						If LICENSEE shall be in default of any material obligation hereunder, and shall fail to remedy such default within ninety (90) days after notice thereof by PRF, this Agreement may be terminated at the option of PRF by notice to that effect.

				

		
			 
		

			
					
						 

					
					
						12.2

					
					
						LICENSEE shall have the right to terminate this Agreement at any time by giving notice in writing to PRF of its intent to do so at least sixty (60) days prior to a termination date designated in said notice. In the event this Agreement is terminated pursuant to this paragraph 12.2, LICENSEE must pay PRF, not later than sixty (60) days after said designated termination, any royalties due under Article IV prior to the designated termination date.

				

		
			 
		

			
					
						 

					
					
						12.3

					
					
						In the event of any termination under this Article, LICENSEE shall, at PRF’s request, assign its rights under any sublicense agreement hereunder to PRF.

				

		
			 
		

			
					
						 

					
					
						12.4

					
					
						Unless otherwise terminated as provided herein, this Agreement shall remain in full force and effect until the expiration of the last-to-expire of the Valid Claim or Claims.

				

		
			 
		

			
					
						 

					
					
						12.5

					
					
						This License Agreement shall be voidable by PRF in the event LICENSEE files bankruptcy.

				

		
			 
		

		
			ARTICLE XIII — PAYMENTS, NOTICES, AND OTHER COMMUNICATIONS
		

		
			 
		

			
					
						 

					
					
						13.1

					
					
						Service of all notices or reports provided for herein shall be deemed duly given if sent by registered or certified mail, postage prepaid, to the addresses below. The date of mailing shall be the date of such notice.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  10  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						LICENSEE:

					
					
						President

				
	
					
						   

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						1291 Cumberland, Suite E

				
	
					
						 

					
					
						West Lafayette, Indiana 47906

				
	
					
						 

					
					
						 

				
	
					
						PRF:

					
					
						Office of Technology Transfer (P-88080)

				
	
					
						 

					
					
						Purdue Research Foundation

				
	
					
						 

					
					
						1063 Hovde Hall, Room 300

				
	
					
						 

					
					
						West Lafayette, IN 47907-1063

				

		
			 
		

			
					
						 

					
					
						13.2

					
					
						LICENSEE agrees to give PRF reasonable notice of all management meetings to be held by LICENSEE involving the Licensed Products and will permit PRF to attend all such meetings.

				

		
			 
		

		
			ARTICLE XIV — GENERAL
		

		
			 
		

			
					
						 

					
					
						14.1

					
					
						PRF warrants and represents that as of the date of this Agreement it is the exclusive and sole owner of the Patents and that PRF has the right to make the conveyances set forth herein.

				

		
			 
		

			
					
						 

					
					
						14.2

					
					
						LICENSEE shall mark the Licensed Products in accordance with 35 U.S.C. 287 and shall require same of any Affiliates or sublicensees.

				

		
			 
		

			
					
						 

					
					
						14.3

					
					
						PRF shall not be liable to LICENSEE for failure by LICENSEE to obtain profit or income from Licensed Products.

				

		
			 
		

			
					
						 

					
					
						14.4

					
					
						This Agreement shall be construed according to the laws of the State of Indiana. It constitutes the entire agreement between the Parties hereto with respect to the subject matter hereof and may not be modified or extended except by written document signed by an executive officer of the Parties.

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  11  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			IN WITNESS WHEREOF, the Parties hereto have caused this instrument to be executed by their duly authorized officers as of the day and year first above written.
		

		
			 
		

			
					
						PURDUE RESEARCH FOUNDATION

					
					
						 

					
					
						ENDOCYTE CORPORATION

					
					
						 

				
	
					
						(PRF)

					
					
						 

					
					
						(LICENSEE)

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						/s/ William E. Baitinger

					
					
						 

					
					
						/s/ P. Ron Ellis

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Signature

					
					
						 

					
					
						Signature

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						William E. Baitinger

					
					
						 

					
					
						P. Ron Ellis

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Typed Name

					
					
						 

					
					
						Typed Name

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Senior Technology Manager

					
					
						 

					
					
						President/CEO

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Title

					
					
						 

					
					
						Title

					
					
						 

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  12  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			Appendix A
		

		
			 
		

		
			ADD:
		

		
			 
		

		
			Title:
		

		
			 
		

		
			STRATEGY FOR PHARMACEUTICAL TARGETING
		

		
			 
		

			
					
						Purdue

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Reference

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						Filing/

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Number

					
					
						 

					
					
						Matter #

					
					
						 

					
					
						Serial #

					
					
						 

					
					
						Issue Date

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-00110.00.WO

					
					
						 

					
					
						290.00260201

					
					
						 

					
					
						PCT/US02/13045

					
					
						 

					
					
						4/24/02

					
					
						 

					
					
						FOLATE MIMETICS AND
FOLATE-RECEPTOR BINDING CONJUGATES THEREOF

					
					
						 

					
					
						File Demand for
Preliminary Examination
By 11/24/02

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			APPENDIX A
		

		
			 
		

		
			U.S. Patents and Patent Applications
		

		
			 
		

		
			S/N 07/690,530
S/N 08/254,299
S/N 08/630,383
S/N 08/752,671
S/N 09/541,482
S/N 09/452,727
S/N 09/506,505
		

		
			 
		

		
			PCT Applications
		

		
			 
		

		
			PCT/US97/05842
PCT/US97/18475
		

		
			 
		

		
			Foreign Patents and Patent Applications
		

		
			 
		

		
			European Patent No. 0 510 949 B (based on European Patent Application No. 92303618.0)
European Patent Application No. 97917902.5
European Patent Application No. 97949336.8
		

		
			 
		

		
			Japanese Patent No. 3105629 (based on Japanese Patent Application No. 04-89223)
Japanese Patent Application No. 9-536451
		

		
			 
		

		
			Canadian Patent Application No. 2066810
Canadian Patent Application No. 2218737
		

		
			 
		

		
			Australian Patent Application No. 26100/97
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 21st day of February, 2001 amends the Agreement executed October 21, 1998 between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

			
					
						1.

					
					
						 

					
					
						Appendix A

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						The following technology entitled, “Folate Mediated Targeting of Antigens and Haptens to Tumors” (PRF Ref. No.: P-99072) is being added to the Exclusive License Agreement executed on October 21, 1998.

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						PRF is the owner of this technology by assignment of the United States Patents and corresponding patents in other countries (hereinafter, together with all divisions, continuations, continuations-in-part, foreign counterparts, and reissues thereof).

				

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			 
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Elizabeth J. Kuuttila

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Elizabeth J. Kuuttila

					
					
						 

					
					
						 

					
					
						P. Ron Ellis

				
	
					
						 

					
					
						Asst. Vice President and Director

					
					
						 

					
					
						 

					
					
						President and CEO

				

		
			 
		

			
					
						Agreed and Acknowledged 

					
					
						 

				
	
					
						 

					
					
						 

				
	
					
						/s/ Philip S. Low

					
					
						 

				
	
					
						Philip S. Low 

					
					
						 

				

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			AMENDMENT TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			

		 

 

		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 21st day of February, 2001 amends the Agreement executed October 21, 1998 between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

			
					
						1.

					
					
						 

					
					
						Appendix A

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						The following technology entitled, “Macrophage Killing Using Ligand-Immunogen Conjugates” (PRF Ref. No.: P-01023) is being added to the Exclusive License Agreement executed on October 21, 1998.

				
	
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						PRF is the owner of this technology by assignment of the United States Patents and corresponding patents in other countries (hereinafter, together with all divisions, continuations, continuations-in-part, foreign counterparts, and reissues thereof).

				

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			 
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Elizabeth J. Kuuttila

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Elizabeth J. Kuuttila

					
					
						 

					
					
						 

					
					
						P. Ron Ellis

				
	
					
						 

					
					
						Asst. Vice President and Director

					
					
						 

					
					
						 

					
					
						President and CEO

				

		
			 
		

			
					
						Agreed and Acknowledged 

					
					
						 

				
	
					
						 

					
					
						 

				
	
					
						/s/ Philip S. Low

					
					
						 

				
	
					
						Philip S. Low 

					
					
						 

				

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT #4 TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 17th day of June, 2002 amends the Agreement executed October 21, 1998 between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

		
			Witnesseth
		

		
			 
		

		
			Add
		

		
			 
		

		
			PRF and LICENSEE are joint owners of technology disclosed as P-00110.
		

		
			 
		

		
			Grant
		

		
			 
		

		
			Replace
		

		
			 
		

		
			Article 2.1 — PRF grants, subject to the terms of this Agreement to the extent of its rights in Patents, a royalty-bearing, exclusive license under the Patents to make, to have made, use, sell and import and sell Licensed Products in the Field of Use in the Territory.
		

		
			 
		

		
			Patent Prosecution
		

		
			 
		

		
			Add
		

		
			 
		

		
			Article 6.6 — LICENSEE is responsible for prior patent costs for P-00110 in the amount of $10,293.05 whether or not such fees and costs were incurred before or after the date of Agreement. LICENSEE shall pay patent costs in three (3) installments beginning upon execution of the Amendment and three (3) month intervals after such date. See schedule below:
		

		
			 
		

			
					
						Upon execution of Amendment

					
					
						 

					
					
						$

					
3,431.01
					
					
						 

				
	
					
						3 months after execution

					
					
						 

					
					
						$

					
3,431.02
					
					
						 

				
	
					
						3 months after last payment

					
					
						 

					
					
						$

					
3,431.02
					
					
						 

				

		
			 
		

		
			Appendix A
		

		
			 
		

		
			Add technology entitled, “Strategy for Pharmaceutica Targeting” (PRF Ref. No.: P-00110), see attached.
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Elizabeth J. Kuuttila

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Elizabeth J. Kuuttila

					
					
						 

					
					
						 

					
					
						Name

					
					
						P. Ron Ellis

				
	
					
						 

					
					
						Asst. Vice President and Director

					
					
						 

					
					
						 

					
					
						 

					
					
						President and CEO

				

		
			 
		

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT #5 TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 20th day of November, 2002 amends the Agreement executed October 21,1998 between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

			
					
						 

					
					
						1.

					
					
						WITNESSETH

				

		
			 
		

		
			Add
		

		
			 
		

		
			PRF is the owner of the technology entitled, “Method of Treatment Using Ligand-Immunogen Conjugates (Toll-like receptors)” PRF Reference Number P-01118 by assignment of the United States Patents and corresponding patents in other countries (hereinafter, together with all divisions, continuations, continuations-in-part, foreign counterparts, and reissues thereof).
		

		
			 
		

			
					
						 

					
					
						2.

					
					
						Appendix A

				

		
			 
		

		
			Replace with the following Appendix A
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date fist above written.
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Elizabeth J. Kuuttila

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Name:

					
					
						Elizabeth J. Kuuttila

					
					
						 

					
					
						 

					
					
						P. Ron Ellis

				
	
					
						 

					
					
						Title:

					
					
						Assistant Vice President

					
					
						 

					
					
						 

					
					
						President & CEO

				
	
					
						 

					
					
						 

					
					
						for Technology Commercialization

					
					
						 

					
					
						 

					
					
						 

				

		
			 
		

		
			  
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			 
		

		
			 
		

		
			

		 

 

		

		
			APPENDIX A
		

		
			United States Patents Granted and Applications Pending
		

			
					
						 

					
						 

					
						 

					
					
						 

					
						 

					
						 

					
					
						 

					
						 

					
						 

					
					
						 

					
						Date

					
						 

					
					
						 

					
						 

					
						 

					
					
						 

					
						 

					
						 

					
						 

				
	
					
						Purdue 

					
						Reference 

					
						Number

					
					
						 

					
						 

					
						Matter #

					
					
						 

					
						 

					
						Serial #

					
					
						       

					
						Issue/Filing

					
						       Date

					
					
						 

					
						 

					
						Title

					
					
						 

					
						 

					
						Status

					
						 

				
	
					
						 

					
						P-88080.10.US

					
					
						 

					
						20035

					
					
						 

					
						07/498,762

					
					
						 

					
						3/28/90

					
						4/28/92

					
					
						 

					
						Method of Enhanced 

					
						Transmembrane Transport 

					
						of Exogenous Molecules 

					
						(continuaiton of P-88080 

					
						now abandoned) (biotin, 

					
						riboflavin)

					
						 

					
					
						 

					
						(CIP of 07/331,816, 4/30/89 ABAN)

					
						Patent No. 5,108,921; Expires 4/28/2009

					
						 

					
						 

				
	
					
						P-88080.20.US

					
					
						21712

					
					
						07/851,544

					
					
						3/13/92

					
						5/16/95

					
					
						Method of Enhanced

					
						Transmembrane Transport

					
						of Exogenous Molecules

					
						(folate)

					
						 

					
					
						U.S. Patent No. 5,416,016

					
						Expires 5/16/2012

					
						 

					
						 

					
						 

				
	
					
						P-88080.30.US

					
					
						25043

					
					
						08/349,407

					
					
						12/05/94

					
						6/3/97

					
					
						Method of Enhanced

					
						Transmembrane Transport 

					
						of Exogenous Molecules

					
						(thiamin)

					
						 

					
					
						U.S. Patent No. 5,635,382

					
						Expires 12/5/2014

					
						 

					
						 

					
						 

				
	
					
						P-88080.3A.US

					
					
						28035

					
					
						08/784,019

					
					
						1/15/97

					
						10/13/98

					
					
						Method for Targeting a 

					
						Diagnostic Agent to Cells 

					
						(no transmembrane 

					
						transport required)

					
						 

					
					
						U.S. Patent No. 5,820,847

					
						Expires 1/15/2017

					
						 

					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						P-88080.40.US

					
					
						25124

					
					
						08/442,174

					
					
						5/16/95

					
						11/18/97

					
					
						Composition and Method for 

					
						Tumor Imaging

					
						 

					
						 

					
					
						U.S. Patent No. 5,688,488

					
						Expires 5/16/2015

					
						 

					
						 

				
	
					
						P-96114.00.US

					
						 

					
						G:\USERS\SOS\OTT\AGREEMNT\ENDOAPDX.DOC

					
					
						62306

					
					
						N/A

					
					
						10/16/98

					
					
						Folic Acid Derivatives

					
						 

					
						 

					
					
						U.S. Nationalized PCT filed 4/17/00

					
						 

					
						06/13/00

					
						 

					
						 

				
	
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						   

				

		
			 
		

		
			1
		

		
			

		 

 

		

		
			 
		

		
			 
		

		
			 
		

			
					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
					
						 

					
						Date

					
						 

					
						 

					
						 

					
						 

					
					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

				
	
					
						Purdue 

					
						Reference 

					
						Number

					
						 

					
						 

					
						P-99072.P1.US

					
					
						 

					
						 

					
						Matter#

					
						 

					
						 

					
						65007

					
					
						 

					
						 

					
						Serial #

					
						 

					
						 

					
						N/A

					
					
						       

					
						Issue/Filing

					
						       Date

					
						-    -

					
						 

					
						3/31/00

					
					
						 

					
						 

					
						Title

					
						 

					
						 

					
						Method of Treatment Using

					
						Lignad-Immunogen

					
						Conjugates

					
					
						 

					
						 

					
						Status

					
						 

					
						Provisional Filed

					
						 

					
						 

				

		
			 
		

		
			INDS02 JZB 219872
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			G:\USERS\SOS\OTT\AGREEMNT\ENDOAPDX.DOC06/13/00
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						   

				

		
			2
		

		
			
		

		
			

		 

 

		

		
			U.S. Parent: Matter No. 20035 (P-88080.1), U.S. Patent 5,108,921
		

		
			FOREIGN COUNTERPARTS
		

			
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Purdue Ref. #

					
					
						Matter#

					
					
						Application No.

					
					
						Country Filed

					
					
						Status

				
	
					
						 

					
						P-88080.10.EP

					
						 

					
					
						 

					
						21407

					
					
						 

					
						90906542.7-21

					
					
						 

					
						E.P.C.

					
					
						 

					
						Application published

					
						1/22/92 as Publication

					
						No.0466816;Application

					
						Granted 11/26/97

					
						Claims directed to biotin and 

					
						folate

					
						 

				
	
					
						P-88080.10.JP

					
					
						21408

					
					
						2-506140

					
					
						Japan

					
					
						Application filed: 4/2/90

					
						Requested Exam 3/13/97

					
						claims conformed to EPO

					
						 

				
	
					
						P-88080.10.IE

					
					
						20070

					
					
						1201/90

					
					
						Ireland

					
					
						Application filed: 4/3/90

					
						Copy of EPO granted

					
						application filed

					
						 

				
	
					
						P-88080.10.CA

					
					
						 

					
						20071

					
					
						2013582-4

					
					
						Canada

					
					
						Application filed 4/2/90

					
						Requested Exam 3/13/97

					
						claims conformed to EPO

					
						 

				
	
					
						P-88080.10.IL

					
					
						20072

					
					
						93983

					
					
						Israel

					
					
						Application filed: 4/2/90

					
						Application issued May 19,

					
						1997

					
						Expires 4/2/2010

					
						 

				
	
					
						P-88080.10.ZA

					
					
						20073

					
					
						90/2538

					
					
						South Africa

					
					
						Patent Issued: 1/30/91

					
						Patent No. 90/2538

					
						Expires April 3, 2010

					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						G:\USERS\SOS\OTT\AGREEMNT\ENDOAPDX.DOC                                                                                                                                                                                                                            06/13/00

					
						 

					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						   

				

		
			 
		

		
			3
		

		
			
		

		
			

		 

 

		

		
			 
		

		
			20080-----------SingaporeApplication abandoned 
		

		
			November 11, 1997
		

		
			 
		

			
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
						 

				
	
					
						Purdue Ref  #

					
					
						Matter#

					
					
						Application No.

					
					
						Country Filed

					
					
						Status

					
						 

				
	
					
						P-88080.10.AT

					
					
						28833

					
					
						90906542.7-2105

					
					
						Austria

					
					
						Issued 11/26/97

					
						Patent No. ATE 160583T

					
						 

					
						 

				
	
					
						P-88080.10.BE

					
					
						28834

					
					
						90906542.7-2105

					
					
						Belgium

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

					
						 

				
	
					
						P-88080.10.CH

					
					
						28835

					
					
						90906542.7-2105

					
					
						Switzerland

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

					
						 

				
	
					
						P-88080.10.DE

					
					
						28836

					
					
						90906542.7-2105

					
					
						Germany

					
					
						Issued 11/26/97

					
						Patent No. 69031763.8

					
						 

					
						 

				
	
					
						P-88080.10.DK

					
					
						28837

					
					
						90906542.7-2105

					
					
						Denmark

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

					
						 

				
	
					
						P-88080.10.ES

					
					
						28838

					
					
						90906542.7-2105

					
					
						Spain

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

				
	
					
						P-88080.10.FR

					
					
						28839

					
					
						90906542.7-2105

					
					
						France

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

				
	
					
						P-88080.10.GB

					
					
						28840

					
					
						90906542.7-2105

					
					
						Great Britain

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

				
	
					
						P-88080.10.IT

					
					
						28841

					
					
						90906542.7-2105

					
					
						Italy

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						06/13/00

					
						 

				
	
					
						G:\USERS\SOS\OTT\AGREEMNT\ENDOAPDX.DOC                                                                                                                                                                                                                                                               

					
						 

					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						   

				

		
			4
		

		
			

		 

 

		

		
			U.S. Parent: Matter No. 20035 (P-88080.1), U.S. Patent 5,108,921
		

		
			FOREIGN COUNTERPARTS
		

		
			 
		

			
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Purdue Ref #

					
						 

					
					
						Matter #

					
					
						Application No.

					
					
						Country Filed

					
					
						Status

				
	
					
						P-88080.10.LU

					
					
						28842

					
					
						90906542.7-2105

					
					
						Luxemburg

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

				
	
					
						P-88080.10.NL

					
					
						28843

					
					
						90906542.7-2105

					
					
						Netherlands

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

				
	
					
						P-88080.10.SE

					
					
						28844

					
					
						90906542.7-2105

					
					
						Sweden

					
					
						Issued 11/26/97

					
						Patent No. 0466816

					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						06/13/00

				
	
					
						G:\USERS\SOS\OTT\AGREEMNT\ENDOAPDX.DOC                                                                                                                                                                                                                                        

					
						 

					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						   

				

		
			 
		

		
			 
		

		
			5
		

		
			
		

		
			

		 

 

		

		
			U.S. Parent:MatterNo.25124 (P-94096), U.S. Patent No. 5,688,488
		

		
			 
		

		
			FOREIGN COUNTERPARTS
		

		
			 
		

			
					
						Purdue Ref #

					
					
						Matter#

					
					
						Application No.

					
					
						Country Filed

					
					
						Status

				
	
					
						 

					
						P-94096.00.WO

					
					
						 

					
						26855

					
					
						 

					
						PCT/US96/07002

					
					
						 

					
						PCT

					
					
						 

					
						Abandoned in favor 

					
						of national applications

				
	
					
						 

					
						P-94096.00.CA

					
					
						 

					
						29190

					
					
						 

					
						2220008

					
					
						 

					
						Canada

					
					
						 

					
						Application filed 5/16/96

					
						Request for Exam filed 3/97

				
	
					
						 

					
						P-94096.00.EP

					
					
						 

					
						29191

					
					
						 

					
						96916476.3

					
					
						 

					
						E.P.C.

					
					
						 

					
						Application filed 5/16/96

				
	
					
						 

					
						P-94096.00.JP

					
					
						 

					
						29192

					
					
						 

					
						08-535034

					
					
						 

					
						Japan

					
					
						 

					
						Application filed: 5/16/96

					
						Request for Exam filed 3/97

				

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			 
		

		
			G:\USERS\SOS\OTT\AGREEMNT\ENDOAPDX.DOC                                                                                                                                                                                                                                                                               06/13/00
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						   

				

		
			 
		

		
			6
		

		
			 
		

		
			 
		

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT #6 TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 22nd day of April, 2003 amends the Agreement executed October 21, 1998, (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

			
					
						 

					
					
						1.

					
					
						Appendix A

				

		
			 
		

		
			LICENSEE has requested and PRF agrees to add the following technologies entitled, “Imaging of Inflammation in Atherosclerosis” PRF reference number P-03046 and “Lupus” PRF reference number P-03055.
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Simran Trana

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Simran Trana

					
					
						 

					
					
						 

					
					
						P. Ron Ellis

				
	
					
						 

					
					
						Director, Life Sciences

					
					
						 

					
					
						 

					
					
						President & CEO

				

		
			 
		

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 7th day of, June 2006 amends the Agreement executed October 21, 1998, (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte, Inc. (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

		
			Licensee has requested and PRF agrees to add the following technology entitled “Folate-receptor Targeted Therapy to Monocyte-induced Inflammation” PRF Reference No. 64327 to Appendix A of the AGREEMENT.
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte, Inc.

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Joseph B. Hornett

					
					
						 

					
					
						By:

					
					
						/s/ Ron P. Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Joseph B. Hornett

					
					
						 

					
					
						 

					
					
						Ron P. Ellis

				
	
					
						 

					
					
						Senior Vice President

					
					
						 

					
					
						 

					
					
						President & CEO

				

		
			 
		

			
					
						Date:

					
					
						6/8/2006

					
					
						 

					
					
						Date:

					
					
						June 8, 2006

				

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 10th day of, October 2006 amends the Agreement executed October 21, 1998, (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte, Inc. (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

		
			Licensee has requested and PRF agrees to add the following technology entitled “Folate Receptor Positive Endothelial Progenitor Cells (EPC)” PRF Reference No. 64556 to Appendix A of the AGREEMENT.
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			  
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte, Inc.

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Joseph B. Hornett

					
					
						 

					
					
						By:

					
					
						/s/ Ron P. Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Joseph B. Hornett
Senior Vice President

					
					
						 

					
					
						 

					
					
						Ron P. Ellis
President & CEO

				

		
			 
		

			
					
						Date:

					
					
						10/12/2006

					
					
						 

					
					
						Date:

					
					
						12 Oct 06

				

		
			 
		

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 10th day of October, 2006 amends the Agreement executed October 21, 1998, (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte, Inc. (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

		
			Licensee has requested and PRF agrees to add the following technology entitled “Detection of Folate Binding Protein with Enhanced Sensitivity Using a Functionalized Quartz Crystal Microbalance Sensor” PRF Reference No. 64616 to Appendix A of the AGREEMENT.
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte, Inc.

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Joseph B. Hornett

					
					
						 

					
					
						By:

					
					
						/s/ Ron P. Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Joseph B. Hornett

					
					
						 

					
					
						 

					
					
						Ron P. Ellis

				
	
					
						 

					
					
						Senior Vice President

					
					
						 

					
					
						 

					
					
						President & CEO

				

		
			 
		

			
					
						Date:

					
					
						10/12/2006

					
					
						 

					
					
						Date:

					
					
						12 Oct 06

				

		
			 
		

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

					
						-  2  -

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT #9 TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 1st day of, December 2006 amends the Agreement executed October 21, 1998, (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte, Inc. (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

		
			Licensee has requested and PRF agrees to add the following technologies to Appendix A of the AGREEMENT.
		

		
			 
		

		
			“Low Dose Irradiation Enhances the Efficacy of Folate-hapten Targeted Immunotherapy” PRF Reference No. 64510 and “Folate Compounds Conjugated to F-18 for Use as Disease Diagnostics/Prognostics” PRF Reference No. 64261
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			  
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte, Inc.

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Joseph B. Hornett

					
					
						 

					
					
						By:

					
					
						/s/ Ron P. Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Joseph B. Hornett

					
					
						 

					
					
						 

					
					
						Ron P. Ellis

				
	
					
						 

					
					
						Senior Vice President

					
					
						 

					
					
						 

					
					
						President & CEO

				

		
			 
		

			
					
						Date:

					
					
						12/8/2006

					
					
						 

					
					
						Date:

					
					
						Dec. 8, 2006

				

		
			  
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT #10 TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 22nd day of May, 2007 amends the Amended and Restated Agreement executed on October 21, 1998, (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE).
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

		
			LICENSEE has requested and PRF agrees to add the following technologies to Appendix A of the AGREEMENT
		

		
			 
		

		
			“Method of Imaging Localized Infections” PRF reference number 64811;
		

		
			 
		

		
			“Novel PET Imaging Agents” PRF reference number 64812
		

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			  
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Joseph B. Hornett

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Joseph B. Hornett
Senior VP, Treasurer & COO

					
					
						 

					
					
						 

					
					
						P. Ron Ellis
President & CEO

				

		
			 
		

			
					
						 

					
					
						 

					
					
						 

					
					
						Date:

					
					
						23 May 07

				

		
			  
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT #11 TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 25th day of April, 2008 (“Amendment Effective Date”) amends the Amended and Restated License Agreement executed on October 21st, 1998, (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE) with respect to the matters addressed in this Agreement.
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

		
			The following Patents are added to Appendix A of the AGREEMENT as of the Amendment Effective Date.
		

		
			 
		

			
					
						 

					
					
						1.

					
					
						“In Vivo Multiphoton Flow Cytometer” PRF Reference No. 64399

				

		
			 
		

		
			       Field of Use for 64399 is limited to Folate-dependent uses only.
		

		
			 
		

			
					
						Purdue Ref. No:

					
					
						 

					
					
						Serial/Patent No.

					
					
						 

					
					
						Country

					
					
						 

					
					
						File/Issue Date

					
					
						 

					
					
						Comments

				
	
					
						64399.00.US

					
					
						 

					
					
						N/A

					
					
						 

					
					
						U.S.

					
					
						 

					
					
						3/21/2008

					
					
						 

					
					
						Filed

				
	
					
						64399.00.WO

					
					
						 

					
					
						PCT/US06/037112

					
					
						 

					
					
						World

					
					
						 

					
					
						9/22/2006

					
					
						 

					
					
						Nationalized

				

		
			 
		

			
					
						 

					
					
						2.

					
					
						“Ex-vivo Flow Cytometry Method and Device” PRF Reference No. 64731

				

		
			 
		

			
					
						Purdue Ref. No:

					
					
						 

					
					
						Serial/Patent No.

					
					
						 

					
					
						Country

					
					
						 

					
					
						File/Issue Date

					
					
						 

					
					
						Comments

				
	
					
						64731.00.WO

					
					
						 

					
					
						PCT/US07/023176

					
					
						 

					
					
						World

					
					
						 

					
					
						11/3/2007

					
					
						 

					
					
						Filed

				

		
			 
		

		
			All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			  
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Joseph B. Hornett

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Joseph B. Hornett
Senior VP, Treasurer & COO

					
					
						 

					
					
						 

					
					
						P. Ron Ellis
President & CEO

				

		
			 
		

			
					
						 

					
					
						 

					
					
						 

					
					
						Date:

					
					
						28 Apr 08

				

		
			  
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			AMENDMENT #12 TO
EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			THIS AMENDMENT, made and entered into this 11th day of September, 2009 (“Amendment Effective Date”) amends the Amended and Restated License Agreement executed on October 21st, 1998, and all subsequent Amendments (hereinafter AGREEMENT) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte Corporation (hereinafter known as LICENSEE) with respect to the matters addressed in this Agreement.
		

		
			 
		

		
			NOW THEREFORE, the parties hereto do hereby agree as follows:
		

		
			 
		

			
					
						 

					
					
						1.

					
					
						Amendment #11 added PRF Ref. No. 64399 to the Appendix A of the AGREEMENT. The field of use for 64399 is hereby amended as follows.

				

		
			 
		

		
			Field of Use for 64399 is limited to any vitamin-dependent, including folate-dependent, uses including any process, machine, manufacture, or composition of matter.
		

		
			 
		

			
					
						 

					
					
						2.

					
					
						The following Patents are added to Appendix A of the AGREEMENT “Folate Conjugated Immunogens” PRF Reference No. 64871

				

		
			 
		

			
					
						Purdue Ref. No:

					
					
						 

					
					
						Serial/Patent No.

					
					
						 

					
					
						Country

					
					
						 

					
					
						File/Issue Date

					
					
						 

					
					
						Comments

				
	
					
						64871.P1.US

					
					
						 

					
					
						60/932,823

					
					
						 

					
					
						U.S.

					
					
						 

					
					
						6/1/2007

					
					
						 

					
					
						Filed

				
	
					
						64871.P2.US

					
					
						 

					
					
						60/941,840

					
					
						 

					
					
						U.S.

					
					
						 

					
					
						6/4/2007

					
					
						 

					
					
						Filed

				
	
					
						64871.00.US

					
					
						 

					
					
						12/130,121

					
					
						 

					
					
						U.S.

					
					
						 

					
					
						5/30/2008

					
					
						 

					
					
						Filed

				

		
			 
		

		
			 All other terms and conditions of the original agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first above written.
		

		
			 
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte Corporation

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:

					
					
						/s/ Joseph B. Hornett

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						Joseph B. Hornett

					
					
						 

					
					
						 

					
					
						P. Ron Ellis

				
	
					
						 

					
					
						Senior VP, Treasurer & COO

					
					
						 

					
					
						 

					
					
						President & CEO

				

		
			 
		

			
					
						 

					
					
						 

					
					
						 

					
					
						Date:  

					
					
						1 Oct 09

				

		
			  
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			 
		

		
			 
		

		
			AMENDMENT #13 to EXCLUSIVE LICENSE AGREEMENT
		

		
			 
		

		
			This AMENDMENT, made and entered into effective April 14, 2014 amends the Amended and Restated License Agreement executed on October 21, 1998 and previously amended (hereinafter “Agreement”) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte, Inc. (hereinafter known as LICENSEE) as follows:
		

		
			 
		

			
					
						 

					
					
						1.

					
					
						The following is added to the preamble of the Agreement:

				

		
			 
		

		
			WHEREAS Section 7.1(a) of the Restated Master Research Agreement effective July 1, 2013 (the “MRA”) specifies prospectively from October 21, 1998 that each certain “Eligible Disclosure will be amended to Schedule A of the 1998 License Agreement, and any patent prosecution arising under the Eligible Disclosure will be administered under the 1998 License Agreement”, and
		

		
			 
		

		
			WHEREAS the definition of Patents hereunder shall be deemed to include any and all patent applications, divisionals, continuations, continuations-in-part, foreign counterparts and reissues derived from an Eligible Disclosure (as defined below) that is amended to this Agreement;
		

		
			 
		

			
					
						 

					
					
						2.

					
					
						The following definition is added to the Agreement:

				

		
			 
		

		
			1.11 “Eligible Disclosure” shall have the meaning set forth in the MRA.
		

		
			 
		

			
					
						 

					
					
						3.

					
					
						The following is added to Article 2 of the License Agreement.

				

		
			 
		

		
			2.7 Appendix A constructively includes all Eligible Disclosures that are subject to Article 7.1(a) of the MRA, whether or not those Eligible Disclosures are expressly identified in Appendix A of this Agreement. The Parties shall amend this Agreement no less than annually to update Appendix A to list all constructively included Eligible Disclosures.
		

		
			 
		

			
					
						 

					
					
						4.

					
					
						The following Patents are expressly added to Appendix A of the Agreement:

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						Purdue
Reference
Number

					
					
						 

					
					
						Endocyte
Matter
Number

					
					
						 

					
					
						Application
Number

					
					
						 

					
					
						Filing Date

					
					
						 

					
					
						Patent
Number

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64510.00.US

					
					
						 

					
					
						3220C-206923

					
					
						 

					
					
						12/162,661

					
					
						 

					
					
						7/30/2008

					
					
						 

					
					
						8168164

					
					
						 

					
					
						TARGETED CONJUGATES AND RADIATION

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64812.00.US

					
					
						 

					
					
						3220C-209264

					
					
						 

					
					
						12/526,096

					
					
						 

					
					
						8/06/2009

					
					
						 

					
					
						8586595

					
					
						 

					
					
						POSITRON EMISSION TOMOGRAPHY IMAGING METHOD

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						63046.OA.US

					
					
						 

					
					
						3220C-216202

					
					
						 

					
					
						13/083,121

					
					
						 

					
					
						4/08/2011

					
					
						 

					
					
						8383354

					
					
						 

					
					
						DIAGNOSTIC METHOD FOR ATHEROSCLEROSIS

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						61023.1A.US

					
					
						 

					
					
						3220C-221773

					
					
						 

					
					
						13/529,823

					
					
						 

					
					
						6/21/2012

					
					
						 

					
					
						8388977

					
					
						 

					
					
						DIAGNOSIS OF MACROPHAGE MEDIATED DISEASE

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						96114.00.US

					
					
						 

					
					
						3220C-62306

					
					
						 

					
					
						09/529,682

					
					
						 

					
					
						4/17/2000

					
					
						 

					
					
						6291673

					
					
						 

					
					
						FOLIC ACID DERIVATIVES

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						99072.00.US

					
					
						 

					
					
						3220C-67883

					
					
						 

					
					
						09/822,379

					
					
						 

					
					
						3/30/2001

					
					
						 

					
					
						7033594

					
					
						 

					
					
						METHOD OF TREATMENT USING LIGAND-IMMUNOGEN CONJUGATES

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						61023.00.US

					
					
						 

					
					
						3220C-70808

					
					
						 

					
					
						10/138,275

					
					
						 

					
					
						5/02/2002

					
					
						 

					
					
						7740854

					
					
						 

					
					
						TREATMENT AND DIAGNOSIS OF MACROPHAGE MEDIATED DISEASE

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						63046.00.US

					
					
						 

					
					
						3220C-76260

					
					
						 

					
					
						11/022,088

					
					
						 

					
					
						12/23/2004

					
					
						 

					
					
						7977058

					
					
						 

					
					
						DIAGNOSTIC METHOD FOR ATHEROSCLEROSIS

					
					
						 

					
					
						Issued

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						99072.10.US

					
					
						 

					
					
						3220C-79124

					
					
						 

					
					
						11/274,973

					
					
						 

					
					
						11/16/2005

					
					
						 

					
					
						8105608

					
					
						 

					
					
						METHOD OF TREATMENT USING LIGAND-IMMUNOGEN CONJUGATES

					
					
						 

					
					
						Issued

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						Purdue
Reference
Number

					
					
						 

					
					
						Endocyte
Matter
Number

					
					
						 

					
					
						Application
Number

					
					
						 

					
					
						Filing
Date

					
					
						 

					
					
						Patent
Number

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						65768.04

					
					
						 

					
					
						3220C-223514

					
					
						 

					
					
						PCT/US2013/028277

					
					
						 

					
					
						2/28/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						FOLATE RECEPTOR ALPHA BINDING LIGANDS

					
					
						 

					
					
						Nat’l

					
						 

					
						8/29/14

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						2013-LOW-66472-04

					
					
						 

					
					
						3220C-229212

					
					
						 

					
					
						PCT/US2014/024617

					
					
						 

					
					
						3/12/2014

					
					
						 

					
					
						 

					
					
						 

					
					
						ASTHMA IMAGING AND THERAPY

					
					
						 

					
					
						Nat’l

					
						 

					
						9/15/15

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						61118.00.US

					
					
						 

					
					
						3220C-71268

					
					
						 

					
					
						10/259,006

					
					
						 

					
					
						09/24/2002

					
					
						 

					
					
						 

					
					
						 

					
					
						METHOD OF TREATMENT USING LIGAND-IMMUNOGEN CONJUGATES

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						2013-LOW-66472-03

					
					
						 

					
					
						3220C-229211

					
					
						 

					
					
						14/206,904

					
					
						 

					
					
						3/12/2014

					
					
						 

					
					
						 

					
					
						 

					
					
						ASTHMA IMAGING

					
					
						 

					
					
						Pending 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						2014-LOW-66734-01

					
					
						 

					
					
						3220C-227586

					
					
						 

					
					
						61/906,331

					
					
						 

					
					
						11/19/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						PATIENT SELECTION METHOD FOR INLAMMATION

					
					
						 

					
					
						Convert

					
						 

					
						11/19/14

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64812.10

					
					
						 

					
					
						3220C-227013

					
					
						 

					
					
						14/058,567

					
					
						 

					
					
						10/21/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						POSITRON EMISSION TOMOGRAPHY IMAGING METHOD

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						66214.01

					
					
						 

					
					
						3220C-224636

					
					
						 

					
					
						61/904,387

					
					
						 

					
					
						11/14/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						COMPOUNDS FOR POSITRON EMISSION TOMOGRPAHY

					
					
						 

					
					
						Convert

					
						 

					
						11/14/14

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64327.08

					
					
						 

					
					
						3220C-224488

					
					
						 

					
					
						13/793,654

					
					
						 

					
					
						3/11/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						IMAGING AND THERAPEUTIC METHOD USING MONOCYTES

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						61023.30

					
					
						 

					
					
						3220C-224487

					
					
						 

					
					
						13/795,059

					
					
						 

					
					
						3/12/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						TREATMENT AND DIAGNOSIS OF MACROPHAGE MEDIATED DISEASE

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						63046.13

					
					
						 

					
					
						3220C-223673

					
					
						 

					
					
						13/714,659

					
					
						 

					
					
						12/14/2012

					
					
						 

					
					
						 

					
					
						 

					
					
						DIAGNOSTIC METHOD FOR ATHEROSCLEROSIS CONJUGATES

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

			
					
						Purdue
Reference
Number

					
					
						 

					
					
						Endocyte
Matter 
Number

					
					
						 

					
					
						Application
Number

					
					
						 

					
					
						Filing Date

					
					
						 

					
					
						Patent
Number

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						65514.03

					
					
						 

					
					
						3220C-223498

					
					
						 

					
					
						13/700,358

					
						 

					
					
						 

					
					
						11/27/2012

					
					
						 

					
					
						 

					
					
						 

					
					
						DELIVERY OF AGENTS TO INFLAMED TISSUES USING FOLATE-TARGETED LIPOSOMES

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						61023.1B.US

					
					
						 

					
					
						3220C-221268

					
					
						 

					
					
						13/463,447

					
					
						 

					
					
						5/03/2012

					
					
						 

					
					
						 

					
					
						 

					
					
						TREATMENT AND DIAGNOSIS OF MACROPHAGE MEDIATED DISEASE

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						65296.00.US

					
					
						 

					
					
						3220C-217905

					
					
						 

					
					
						13/254,637

					
					
						 

					
					
						9/2/2011

					
					
						 

					
					
						 

					
					
						 

					
					
						METHOD FOR EARLY IMAGING OF ATHEROSCLEROSIS

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64811.00.US

					
					
						 

					
					
						3220C-210313

					
					
						 

					
					
						12/601,960

					
					
						 

					
					
						9/28/2010

					
					
						 

					
					
						 

					
					
						 

					
					
						METHOD OF IMAGING LOCALIZED INFECTIONS

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64327.10.US

					
					
						 

					
					
						3220C-208461

					
					
						 

					
					
						12/391,981

					
					
						 

					
					
						2/24/2009

					
					
						 

					
					
						 

					
					
						 

					
					
						IMAGING AND THERAPEUTIC METHOD USING MONOCYTES

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						66099-03

					
					
						 

					
					
						 

					
					
						 

					
					
						13/779,501

					
					
						 

					
					
						2/27/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						METHODS FOR TREATING CANCER

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64556-04

					
					
						 

					
					
						 

					
					
						 

					
					
						13/910,306

					
					
						 

					
					
						6/5/2013

					
					
						 

					
					
						 

					
					
						 

					
					
						METHOD OF DETECTING ENDOTHELIAL PROGENITOR CELLS

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						65529.00.US

					
					
						 

					
					
						20150-215800

					
					
						 

					
					
						13/063,889

					
					
						 

					
					
						3/14/2011

					
					
						 

					
					
						 

					
					
						 

					
					
						FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						65401.00.US

					
					
						 

					
					
						20150-216164

					
					
						 

					
					
						13/124,408

					
					
						 

					
					
						4/15/2011

					
					
						 

					
					
						 

					
					
						 

					
					
						FOLATE TARGETING OF NUCLEOTIDES

					
					
						 

					
					
						Pending

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						64261.00.US

					
					
						 

					
					
						3220C-203451

					
					
						 

					
					
						11/793,459

					
					
						 

					
					
						12/23/2005

					
					
						 

					
					
						 

					
					
						 

					
					
						POSITRON EMISSION TOMOGRAPHY IMAGING METHOD

					
					
						 

					
					
						Pending

				

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			 
		

			
					
						Purdue
Reference
Number

					
					
						 

					
					
						Endocyte
Matter 
Number

					
					
						 

					
					
						Application
Number

					
					
						 

					
					
						Filing Date

					
					
						 

					
					
						Patent
Number

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						63055.00.WO

					
					
						 

					
					
						3220C-75156

					
					
						 

					
					
						PCT/US2004/

					
						014097

					
					
						 

					
					
						5/6/2004

					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						CONJUGATES AND USES THEREOF

					
					
						 

					
					
						Expired

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

				

		
			 
		

		
			

		 

 

 
		

			
					
						 

				

		
			  
		

		
			All other terms and conditions of the Agreement remain unchanged and in effect.
		

		
			 
		

		
			IN WITNESS WHEREOF, the parties have executed this AMENDMENT effective as of April 14, 2014.
		

		
			 
		

			
					
						Purdue Research Foundation

					
					
						 

					
					
						Endocyte, Inc.

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						By:  

					
					
						/s/ Daniel J. Hasler

					
					
						 

					
					
						By:

					
					
						/s/ P. Ron Ellis

				

		
			 
		

		
			 
		

			
					
						[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.ecyt_Ex10_2

		
			Exhibit 10.2
		

		
			 
		

		
			CONFIDENTIAL TREATMENT REQUESTED
		

		
			Portions of this Exhibit have been redacted pursuant to a request for confidential treatment under Rule 24b-2 of the General Rules and Regulations under the Securities Exchange Act of 1934, as amended. Omitted information, marked “[*]” in this Exhibit, has been filed separately with the Securities and Exchange Commission together with such request for confidential treatment.
		

		
			 
		

		
			EXCLUSIVE LICENSE AGREEMENT
		

		
			     THIS LICENSE AGREEMENT is made and entered into as of March 1, 2010 (“Effective Date”), by and between PURDUE RESEARCH FOUNDATION, a statutory body corporate formed and existing under the Indiana Foundation or Holding Companies Act of 1921 (hereinafter referred to as “PRF”), and Endocyte Corporation, an Indiana corporation, having a place of business at West Lafayette, Indiana (hereinafter referred to as “LICENSEE”) collectively referred to hereinafter as the “Parties.”
		

		
			WITNESSETH:
		

		
			     WHEREAS, PRF is the assignee of the right, title, and interest in the patent-protected materials described in Appendix A attached hereto (hereinafter, together with all provisional applications, divisions, continuations, continuations-in-part, foreign counterparts, and reissues thereof, collectively “Patents”); and
		

		
			WHEREAS, PRF wishes to have the inventions further developed and marketed at the earliest possible time in order that products resulting therefrom may be available for public use and benefit; and
		

		
			WHEREAS, LICENSEE wishes to obtain certain rights to pursue the development and commercialization of the inventions; and
		

		
			WHEREAS, PRF wishes to grant LICENSEE such rights in accordance with the terms and conditions of this Agreement.
		

		
			NOW, THEREFORE, for and in consideration of the mutual covenants and the premises herein contained, the Parties, intending to be legally bound, hereby agree as follows.
		

		
			ARTICLE I — DEFINITIONS
		

		
			     As used herein, the following terms shall have the following meanings:
		

		
			     1.1 “Affiliate” shall mean a corporation, company, partnership, or other business entity which controls or is controlled by, or is under common control with, the designated party. In the case of a corporation or company, “control” means ownership either directly or indirectly of at least fifty percent (50%) of the shares of stock entitled to vote for the election of directors. The term “Affiliate” shall not include a third-party sublicensee of LICENSEE.
		

		
			     1.2 “FDA Approval” shall mean final approval from the United States Food and Drug Administration to distribute, market and sell any Licensed Product in the United States.
		

		
			   
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			     1.3 “Licensed Products” shall mean products falling within the scope of a Valid Claim or claims of the Patents or made by processes within the scope of a Valid Claim or claims of the Patents.
		

		
			     1.4 “Sales Value” shall mean (i) in the case of Licensed Products sold to third parties, the invoice price, F.O.B place of manufacture, exclusive of sales taxes, packing, shipping and insurance charges, and less returns, allowances, and discounts actually allowed; and (ii) in the case of any use of any Licensed Product by LICENSEE, any Affiliate or any third party for the purpose of any testing or studies necessary to obtain FDA Approval, Zero Dollars ($0.00).
		

		
			     1.5 “Valid Claim” shall mean any claim contained in any pending patent application or issued patent included within the Patents which has not been abandoned or declared invalid in a non-appealable order, as the case may be, and which would be infringed by the manufacture, use or sale of Licensed Products in the absence of the licenses granted hereunder.
		

		
			     1.6 “Territory” shall mean all countries, worldwide.
		

		
			     1.7 “Field of Use” shall mean:
		

		
			     (a) All Diagnostic and Imaging Applications; and
		

		
			     (b) All Therapeutic Applications.
		

		
			     1.8 “Therapeutic Applications” shall mean any use of a Licensed Product for the prevention or treatment of disease or injury.
		

		
			     1.9 “Diagnostic or Imaging Applications” shall mean any use of a Licensed Product for purposes of the investigation or determination of the nature or extent of any disease or injury.
		

		
			     1.10 “Know-How” shall mean any and all confidential unpatented and/or non-patentable data, materials, samples and other information owned and controlled by PRF which relate to the Patents or which is useful in the Manufacture, use or sale of Licensed Products.
		

		
			ARTICLE II — GRANTS
		

		
			     2.1 PRF grants, subject to the terms of this Agreement, to LICENSEE a royalty-bearing, exclusive license under the Patents to make, to have made, use, offer for sale, sell and import and sell Licensed Products in the Field of Use in the Territory.
		

		
			 -2- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			     2.2 PRF grants, subject to the terms of this Agreement, to LICENSEE a non-exclusive license under the Know-How to make, to have made, use, offer for sale, sell and import and sell Licensed Products in the Field of Use in the Territory.
		

		
			     2.3 LICENSEE shall have the right to grant sublicenses under the license granted herein, and to extend the sublicenses to any third party or Affiliate of LICENSEE. LICENSEE shall notify PRF promptly of any grant of sublicense hereunder and the terms thereof.
		

		
			     2.4 PRF shall reserve, and the license granted shall be subject to the royalty-free right in PRF (or in Purdue University, if PRF’s rights are assigned to the University) to make or have made for its use (but not to sell) the products or devices (or the rights to practice the process, if a process invention) under each patent, provided that such reserved rights shall be used by PRF (or the University as the case may be) solely for educational and research purposes and not for commercial purposes.
		

		
			     2.5 All rights reserved to the United States Government and others under Public Law 96-517 and 98-620 shall remain and shall in no way be affected by this Agreement.
		

		
			     2.6 PRF hereby warrants that it is the owner of the Patents and that such Patents are not subject to any lien, encumbrance, license or claim of ownership of any third party, except to the extent stated in Section 2.4, in derogation of the rights granted to LICENSEE in this Agreement.
		

		
			ARTICLE III — DILIGENCE
		

		
			     3.1 (a) Diligence and Commercialization . Because the invention is not yet commercially viable as of the Effective Date, LICENSEE will use, or shall cause its Sublicensees to use, commercially reasonable efforts to diligently develop, manufacture, and sell Licensed Product(s). Furthermore, LICENSEE agrees to accomplish the Dilligence Milestone Tasks, (a) to (c) defined in the table below, on or before the stated Due Date for each Dilligence Milestone Task, (a) to (c) as defined below.
		

		
			 -3- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			 
		

			
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Diligence Milestone Tasks

					
					
						 

					
					
						Due Date

					
					
						 

					
					
						Penalty Amount

				
	
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						(a) IND Application Approved

					
					
						 

					
					
						February 28th, 2011

					
					
						 

					
					
						[*]

				
	
					
						(b) Initiation of Phase II clinical trials

					
					
						 

					
					
						February 28th, 2014

					
					
						 

					
					
						[*]

				
	
					
						(c) Initiation of Phase III clinical trials

					
					
						 

					
					
						February 28th, 2014

					
					
						 

					
					
						[*]

				

		
			LICENSEE shall inform PRF, on or before the Diligence Milestone Task Due Date, whether such Diligence Milestone Task has been accomplished. If any of Diligence Milestone Tasks (a) to (c) above are not completed on or before their respective Due Date, LICENSEE may cure each such failure to accomplish such Diligence Milestone Task by payment to PRF of the associated Penalty Amount, as defined in the table above, within thirty (30) days of the respective missed Dilligence Milestone Task Due Date. For clarity, the Penalty Amounts paid by LICENSEE to cure each failure to accomplish a Dilligence Milestone Task by the respective Due Date is separate from any earned royalty and/or minimum annual royalty payments owed to PRF.
		

		
			     3.2 Commencing twenty-four (24) months following FDA Approval, if, at any time, PRF is of the reasonable opinion that LICENSEE is not meeting the public demand, as outlined below, for Licensed Products, PRF shall notify LICENSEE to that effect and LICENSEE shall have six (6) months after such notice within which to meet such demand or to make other arrangements satisfactory to PRF. If at the end of six (6) months’ period PRF is not satisfied that the public demand is or will be reasonably met by LICENSEE, PRF may, at its option, terminate the license or convert the exclusive license to a non-exclusive license upon sixty (60) days’ notice to LICENSEE. Net sales, based upon Sales Value, of Five Hundred Thousand Dollars ($500,000) or more of the Licensed Products by LICENSEE and any sublicensees during the first twenty-four (24) following FDA Approval shall be regarded by PRF as meeting the public demand.
		

		
			ARTICLE IV — PRF ROYALTY OBLIGATIONS AND MILESTONE PAYMENT
		

		
			     4.1 Subject to all the terms and conditions of this Agreement, for each calendar year this Agreement is in effect, LICENSEE shall pay to PRF an earned royalty, which shall be agreed to in writing by the parties and which shall not exceed the maximum percentages set forth below, calculated as a percentage of the Sales Value of Licensed Products made, used, sold or imported by LICENSEE, it sublicensees or its Affiliates in each country of the Territory in which there is (are) valid unexpired Patents. The royalties due hereunder shall be payable on a country-by-country basis in each country until the expiration of the last to expire
		

		
			 
		

		
			 -4- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			of the Patents covering the Licensed Products or the manufacture use or sale of the Licensed Products in such country. The royalty percentage for therapeutic applications shall be [*] of the Sales Value of Licensed Products used or sold for sales up to [*], and [*] of the Sales Value of Licensed Products used or sold for sales in excess of [*]. The royalty percentage for diagnostic applications shall be [*] of the Sales Value of Licensed Products used or sold for sales up to [*], and [*] of the Sales Value of Licensed Products used or sold for sales in excess of [*].
		

		
			At any time during the term of this agreement prior to the initiation of a Phase III clinical trial of a Licensed Product, Endocyte will have the right to buy down the royalty rates for therapeutic applications or diagnostic applications from PRF at a rate of $[*] for each [*]% point decrease in royalty.
		

		
			At any time after the commencement of Phase III clinical trial and before Data Base Lock of the Phase III clinical trial of a Licensed Product, Endocyte will have the right to buy down the royalty rates for therapeutic applications or diagnostic applications from PRF at a rate of $[*]for each[*]% point decrease in royalty.
		

		
			Should Endocyte wish to buy down the royalty rate on either diagnostic or therapeutic applications following Data Base Lock of a Phase III clinical trial of a Licensed Product, Endocyte will meet with PRF to negotiate a mutually agreeable price for the buy-down in dollars per percent decrease of royalty rate.
		

		
			Endocyte shall not under any circumstances have the right to buy down any royalty rate on therapeutic applications below [*]. Endocyte shall not have the right to buy down any royalty rate on diagnostic applications below [*].
		

		
			     4.2 LICENSEE shall pay to PRF an annual minimum royalty for each calendar year during the life of this Agreement beginning in calendar year 2010. The minimum royalty shall be payable on or before December 31 of each such calendar year. Prior to the first commercial sale of a Licensed Product the minimum annual royalty shall be fifteen thousand dollars ($15,000.00). Following the first commercial sale of a Licensed Product the minimum annual royalty shall be one hundred thousand dollars ($100,000.00).
		

		
			If earned royalties for any calendar year do not equal or exceed the minimum royalty owed for that calendar year, LICENSEE shall pay PRF an amount equal to the difference between the calendar year earned royalty and the calendar year
		

		
			 
		

		
			 -5- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

minimum royalty, said amount payable on or before January 31 of the next following calendar year.
		

		
			     4.3 Upon approval of a New Drug Application (“NDA”) in the United States for a Licensed Product, LICENSEE will pay PRF a Milestone Payment (“Milestone Payment”) of five-hundred thousand dollars ($500,000.00). Milestone Payment is due to PRF within one hundred eighty (180) days from the date of NDA approval. For clarity, Milestone Payment is separate from earned royalty and/or minimum annual royalty payments owed by LICENSEE to PRF.
		

		
			ARTICLE V — RECORDS, REPORTS, PAYMENTS
		

		
			     5.1 LICENSEE shall keep accurate books and records showing all sales and use by LICENSEE and its sublicensee of Licensed Products, together with such other information as shall be necessary to enable earned royalties to be computed, and such books and records showing all sales and use by LICENSEE and its sublicensee of Licensed Products shall be kept for a period of three (3) years from the creation of such books and records. On or before the last day of March, June, September, and December of each year during the life of this Agreement, LICENSEE shall render to PRF a written report showing the calculation, in reasonable detail, of earned royalty for the preceding calendar quarter and shall accompany each such report with payment of any amount shown to be due. Such reports are to be made by LICENSEE whether or not royalties are owed. Such reports and any royalties due will be made to PRF within thirty (30) days of the end of each calendar quarter. Not more than once per calendar year during the term of this Agreement, LICENSEE’s records and books shall be open during reasonable business hours for reasonable inspection by a certified public accountant appointed and paid for by PRF and reasonably acceptable to LICENSEE, to determine the accuracy of such royalty statements and payments but for not other purpose. PRF agrees that it and its designees shall keep confidential and shall not disclose or use for purposes other than those set forth in Section 5.1, any information, report or document provided to or made available to PRF or its designee.
		

		
			ARTICLE VI — PATENT PROSECUTION
		

		
			     6.1 As between PRF and LICENSEE, PRF shall have responsibility for filing, prosecution and maintenance of all Patents in the Territory. LICENSEE shall have the right to review pending Patent applications and make recommendations to PRF concerning them. PRF will consider in good faith all reasonable suggestions of LICENSEE with respect thereto. PRF agrees to keep LICENSEE informed of the course of patent prosecution or other proceedings with respect to the Patents within the Territory. In the event PRF elects not to file, prosecute or
		

		
			 -6- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			maintain any or all of the Patents in the Territory, PRF shall assign this responsibility to LICENSEE and cooperate to assure the filing, prosecution and maintenance of all Patents. The parties shall hold all information disclosed to it under this Section as confidential.
		

		
			     6.2 LICENSEE shall have the right but not the obligation to seek extensions of the terms of Patents in the Territory. At LICENSEE’S request, PRF shall either diligently seek to obtain such extensions or authorize LICENSEE to act as PRF’s agent for the purpose of making any application for any extensions of the term of Patents and provide reasonable assistance therefor to LICENSEE, in either event, at LICENSEE’s expense.
		

		
			     6.3 PRF shall promptly provide LICENSEE copies of all notices and correspondence to or from the U.S .Patent and Trademark Office and any foreign patent offices.
		

		
			     6.4 Payment of all fees and costs relating to the filing, prosecution, and maintenance of the Patents shall be the responsibility of LICENSEE, whether or not such fees and costs were incurred before or after the date of this Agreement.
		

		
			     6.5 PRF will provide all requested Know-How to LICENSEE at LICENSEE’s expense.
		

		
			ARTICLE VII — INFRINGEMENT/ENFORCEMENT
		

		
			     7.1 If during the term of this Agreement one ore more Patents licensed hereunder is or appears to be infringed by a third party within the Field of Use, then the party having knowledge thereof shall notify the other and the parties shall consult to consider what, if any, action should be taken. Under no circumstances shall PRF have the obligation to enforce Patents. LICENSEE shall have the first right (but not the obligation) to notify the infringer and/or initiate litigation or legal proceedings to abate the infringement. In the event LICENSEE commences litigation, LICENSEE shall notify PRF in writing that the litigation has been commenced. PRF may elect to join in any such legal proceedings against the alleged infringer. In the event LICENSEE has not initiated such legal proceedings within six (6) months after becoming aware of the infringement, then PRF may initiate such legal proceedings on its own behalf; and thereafter, LICENSEE may elect to join in those proceedings.
		

		
			     7.2 If PRF elects to join in legal proceedings commenced by LICENSEE or sublicensee, or if LICENSEE or sublicensee elected to join in legal proceedings commanded by PRF, all fees and costs incurred therein, and all damages shall be the responsibility of PRF. If one Party elects not to join in legal proceedings
		

		
			 -7- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			initiated by the other Party, then the initiating Party shall be responsible for all fees and costs incurred therein. All reasonable costs and expenses incurred as a result of said legal proceedings shall be recoverable by LICENSEE or sublicensee out of damages and awards recovered by LICENSEE, sublicensee and/or PRF. Any remaining amounts from damages and awards, once costs and expenses have been recovered, shall be divided between LICENSEE and PRF as follows: LICENSEE shall retain seventy-five percent (75%) and PRF shall retain twenty-five percent (25%) of the damages and awards recovered by LICENSEE. Each Party shall reasonably cooperate with the other Party, whether joining or not, in the conduct of the proceedings (such as by joining in name only); however, where PRF is joined in any such legal proceedings in name only as a necessary party and not at its election, then LICENSEE shall indemnify and hold harmless PRF from and against any and all actions, claims, and counterclaims brought against PRF, and LICENSEE agrees to pay all legal expenses, damages, and costs which may be finally assessed against PRF in such actions, claims, and counterclaims.
		

		
			     7.3 PRF makes no warranty that the subject matter of the invention licensed hereunder will not infringe any third party patent and PRF makes no covenant either to defend any infringement charge by a third party or to institute action against infringers of any Patents hereby licensed.
		

		
			     7.4 If LICENSEE, any sublicensee or customer is named as a defendant in a lawsuit (hereinafter “Defendant”) charging Defendant with patent infringement as a result of its manufacture or sale of Licensed Products or its use of Licensed Products as disclosed in Patents or otherwise contending that Defendant does not have the right to manufacture, sell or so use Licensed Products, and LICENSEE so notifies PRF that such a lawsuit has been filed and provides PRF with copies of the Complaint and all papers associated with its filing. LICENSEE shall have the right to establish an Escrow Account for the mutual benefit of PRF and LICENSEE. For so long as LICENSEE bears any liability for costs or damages as a result of such lawsuit LICENSEE shall be entitled to deposit one-half (1/2) of the royalty payments to be paid to PRF under Paragraph 4.2 hereof into said Escrow Account. The other one-half (1/2) of the royalty payments required to be paid under Paragraph 4.2 hereof shall continue to be paid to PRF under the terms of this Agreement. If no royalty payments are yet due PRF during the period of the defense of any such alleged infringement, LICENSEE shall be entitled to accrue a credit for all sums expended to pay any costs and to pay any damages which may be awarded for infringement, and to offset these expenditures against any royalties to be paid to PRF.
		

		
			The amounts deposited into the Escrow Account shall be used to pay LICENSEE’s out-of-pocket monetary expenses actually incurred in defending the lawsuit, including attorneys’ fees and any damages assessed against Defendant based specifically and only on Defendant’s manufacture, use or sale of Licensed
		

		
			 -8- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			Products. The Escrow account shall be established as a Federally Insured deposit account earning interest not less than money market or equivalent rates. The agreement establishing the Escrow Account shall require the Escrow Agent to provide PRF and LICENSEE with accurate accounting reports, to reimburse LICENSEE for its said expenses as approved in writing by PRF, and to remit to PRF any balance left in said account immediately all costs have been paid and all damage awards have been satisfied. PRF shall approve all of out-of-pocket expenses for reimbursement by the Escrow Agent provided the expenses are accurately documented for PRF and shown to be reasonably necessary to the defense of the lawsuit or an actual payment of assessed damages. LICENSEE shall have no recourse against PRF concerning such a lawsuit other than the provisions of this Section 7.4.
		

		
			ARTICLE VIII — PRODUCT LIABILITY
		

		
			     8.1 LICENSEE shall indemnify and save PRF and/or Purdue University harmless from any and all claims, demands, actions and causes of action against, PRF whether groundless or not, in connection with any and all injuries, losses, damages or liability of any kind whatsoever arising, directly or indirectly, out of use, distribution, or sale of Licensed Products by or through the LICENSEE or its Affiliates or sublicensees whether or not the claims, demands, actions or causes of action are alleged to have resulted in whole or in part from the negligent acts or omissions of PRF and/or Purdue University or from acts or omissions of such persons for which they are or any of them would otherwise be strictly liable. This indemnification obligation shall include, without limiting the generality of the foregoing, reasonable attorney fees and other costs or expenses incurred in connection with the defense of any and all such claims, demands, actions, or causes of action, and shall extend to the Trustees, officers, employees, and agents of PRF and/or Purdue University. This indemnification obligation does not extend to any occurrences or events whether at the PRF’s or Purdue University’s facilities or elsewhere except those occurring in connection with the use, distribution, or sale of Licensed Products by or through LICENSEE, or its Affiliates.
		

		
			     8.2 LICENSEE shall obtain and carry in full force and effect liability insurance which shall protect LICENSEE and PRF in regard to the events covered by Section 8.1 herein. LICENSEE shall name PRF as an additional name insured on said liability insurance. The policy of said liability insurance shall require written notice of termination to be provided to PRF at least thirty (30) days prior to expiration or other cancellation thereof.
		

		
			     8.3 PRF hereby warrants that as of the Effective Date, it is aware of no fact which places the validity of the Patents into question. Further, PRF hereby warrants that as of the Effective Date, it is unaware of any patent or claim by any third party
		

		
			 -9- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			upon the basis of which PRF has any reason to believe that the making, using or selling of any Licensed Product will infringe any valid United States patent.
		

		
			     8.4 EXCEPT TO THE EXTENT EXPRESSLY STATED TO THE CONTRARY IN THIS AGREEMENT, PRF SHALL NOT BE DEEMED TO HAVE MADE ANY REPRESENTATION OR WARRANTY, EXPRESS OR IMPLIED, AS TO THE CONDITION, MERCHANTABILITY, DESIGN, OPERATION OR FITNESS FOR USE OF LICENSED PRODUCTS OR ANY OTHER REPRESENTATION OR WARRANTY WHATSOEVER, EXPRESS OR IMPLIED, WITH RESPECT TO LICENSED PRODUCTS OR PATENTS. PRF EXPRESSLY MAKES NO WARRANTY OF VALIDITY OF PATENTS LICENSED HEREUNDER.
		

		
			ARTICLE IX — EXPORT CONTROLS
		

		
			     9.1 It is understood that PRF is subject to United States laws and regulations controlling the export of technical data, computer software, laboratory prototypes and other commodities (including the Arms Export Control Act, as amended and the Export Administration Act of 1979), and that its obligations hereunder are contingent on compliance with applicable United States export laws and regulations. The transfer of certain technical data and commodities may require a license from the cognizant agency of the United States Government and/or written assurances by LICENSEE that LICENSEE shall not export data or commodities to certain foreign countries without prior approval of such agency. PRF neither represents that a license shall not be required nor that, if required, it shall be issued.
		

		
			ARTICLE X — NON-USE OF NAMES
		

		
			     10.1 LICENSEE shall not use the names of the Purdue Research Foundation nor Purdue University nor any of its employees, nor any adaptation thereof, in any advertising, promotional or sales literature without prior written consent obtained from PRF in each case, except that LICENSEE may state that it is licensed by PRF under one or more of the Patents and/or applications comprising the Patents.
		

		
			     10.2 LICENSEE agrees that it will not under any circumstances advertise or otherwise state or imply that PRF or Purdue University has tested or approved any product or process.
		

		
			ARTICLE XI — ASSIGNMENT
		

		
			     11.1 This Agreement shall inure to the benefit of and be binding upon the Parties hereto, their successors and permitted assigns. LICENSEE shall be permitted to
		

		
			 -10- 
		

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			assign its rights and obligations under this Agreement upon the written consent of PRF, which shall not be unreasonably withheld.
		

		
			ARTICLE XII — TERMINATION
		

		
			     12.1 If LICENSEE shall be in default of any material obligation hereunder, and shall fail to remedy such default within ninety (90) days after notice thereof by PRF, this Agreement may be terminated at the option of PRF by notice to that effect.
		

		
			     12.2 LICENSEE shall have the right to terminate this Agreement at any time by giving notice in writing to PRF of its intent to do so at least sixty (60) days prior to a termination date designated in said notice. In the event this Agreement is terminated pursuant to this paragraph 12.2, LICENSEE must pay PRF, not later than sixty (60) days after said designated termination, any royalties due under Article IV prior to the designated termination date.
		

		
			     12.3 In the event of any termination under this Article, LICENSEE shall, at PRF’s request, assign its rights under any sublicense agreement hereunder to PRF.
		

		
			     12.4 Unless otherwise terminated as provided herein, this Agreement shall remain in full force and effect until the expiration of the last-to-expire of the Valid Claim or Claims.
		

		
			     12.5 This License Agreement shall be voidable by PRF in the event LICENSEE files bankruptcy.
		

		
			ARTICLE XIII — PAYMENTS, NOTICES, AND OTHER COMMUNICATIONS
		

		
			     13.1 Service of all notices or reports provided for herein shall be deemed duly given if sent by registered or certified mail, postage prepaid, to the addresses below. The date of mailing shall be the date of such notice.
		

			
					
						 

					
					
						 

					
					
						 

				
	
					
						LICENSEE:

					
					
						 

					
					
						President
Endocyte Corporation
3000 Kent Avenue, Suite A1-100
West Lafayette, Indiana 47906

				
	
					
						 

					
					
						 

					
					
						 

				
	
					
						PRF:

					
					
						 

					
					
						Office of Technology Commercialization
Purdue Research Foundation
1281 Win Hentschel Blvd.
West Lafayette, IN 47906

				

		
			     13.2 LICENSEE agrees to give PRF reasonable notice of all management meetings to be held by LICENSEE involving the Licensed Products and will permit PRF to attend all such meetings.
		

		
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			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			 
		

		
			ARTICLE XIV — GENERAL
		

		
			     14.1 PRF warrants and represents that as of the date of this Agreement it is the exclusive and sole owner of the Patents and that PRF has the right to make the conveyances set forth herein.
		

		
			     14.2 LICENSEE shall mark the Licensed Products in accordance with 35 U.S.C. 287 and shall require same of any Affiliates or sublicensees.
		

		
			     14.3 PRF shall not be liable to LICENSEE for failure by LICENSEE to obtain profit or income from Licensed Products.
		

		
			     14.3 This Agreement shall be construed according to the laws of the State of Indiana. It constitutes the entire agreement between the Parties hereto with respect to the subject matter hereof and may not be modified or extended except by written document signed by an executive officer of the Parties.
		

		
			     14.4 IN WITNESS WHEREOF, the Parties hereto have caused this instrument to be executed by their duly authorized officers as of the day and year first above written.
		

			
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

				
	
					
						PURDUE RESEARCH FOUNDATION
(PRF)

					
					
						 

					
					
						 

					
					
						 

					
					
						ENDOCYTE CORPORATION
(LICENSEE)

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						/s/ Joseph B. Hornett

					
						 

					
					
						 

					
					
						  

					
					
						 

					
					
						/s/ P. Ron Ellis

					
						 

					
					
						 

					
					
						  

				
	
					
						Signature

					
					
						 

					
					
						 

					
					
						 

					
					
						Signature

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Joseph B Hornett

					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						P. Ron Ellis

					
						 

					
					
						 

					
					
						 

				
	
					
						Typed Name

					
					
						 

					
					
						 

					
					
						 

					
					
						Typed Name

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Sr. VP, Treasurer and COO

					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						President and CEO

					
						 

					
					
						 

					
					
						 

				
	
					
						Title

					
					
						 

					
					
						 

					
					
						 

					
					
						Title

					
					
						 

					
					
						 

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Date: March 1, 2010

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				

		
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			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

 
		

		
			APPENDIX A
		

		
			Pending Applications
		

			
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Purdue

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Reference

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						Number

					
					
						 

					
					
						Matter #

					
					
						 

					
					
						Application Number

					
					
						 

					
					
						Filing Date

					
					
						 

					
					
						Title

					
					
						 

					
					
						Status

				
	
					
						64830

					
					
						 

					
					
						 

					
					
						 

					
					
						PCT/US2008/073375

					
					
						 

					
					
						8/15/2008

					
					
						 

					
					
						PSMA Binding Ligand-Linker Conjugates and Methods for Using

					
					
						 

					
					
						National Phase applications prior to Feb. 17, 2010 deadline; additional provisional application to be filed in US by Feb. 26, 2010

				
	
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

					
					
						 

				
	
					
						65261.00.WO

					
					
						 

					
					
						 

					
					
						 

					
					
						PCT/US2009/061067

					
					
						 

					
					
						10/16/2009

					
					
						 

					
					
						PSMA Binding-Ligand Conjugates and Methods for Using

					
					
						 

					
					
						PCT application filed in October 2009, Nationalization dates for most countries April 17, 2011

				

		
			 
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

AMENDMENT #1 to LICENSE AGREEMENT
		

		
			This AMENDMENT, made and entered into effective April 14, 2014 amends the Amended and Restated License Agreement made effective on March 1, 2010 (hereinafter “Agreement”) between Purdue Research Foundation (hereinafter known as PRF) and Endocyte, Inc. (hereinafter known as LICENSEE) as follows:
		

		
			1. The following is added to the preamble of the Agreement:
		

		
			WHEREAS Section 7.1(b) of the Restated Master Research Agreement effective July 1, 2013 (the “MRA”) specifies prospectively from March 1, 2010 that each certain “Eligible Disclosure will be amended to the 2010 License Agreement, and any patent prosecution arising under the Eligible Disclosure will be administered under the 2010 License Agreement”, and 
		

		
			WHEREAS the definition of Patents hereunder shall be deemed to include any and all patent applications, divisionals, continuations, continuations-in-part, foreign counterparts and reissues derived from an Eligible Disclosure (as defined below) that is amended to this Agreement;
		

		
			2.  The following definition is added to the Agreement:
		

		
			1.11 “Eligible Disclosure” shall have the meaning set forth in the MRA.
		

		
			3.  The following is added to Article II of the Agreement.
		

		
			2.7   Appendix A of this Agreement constructively includes all Eligible Disclosures that are subject to Article 7.1(b) of the MRA, whether or not those Eligible Disclosures are expressly identified in Appendix A of this Agreement.  The Parties shall amend this Agreement no less than annually to update Appendix A to list all constructively included Eligible Disclosures. 
		

		
			4.  The first paragraph of Section 4.1 is replaced in its entirety as follows:
		

		
			4.1 Subject to all the terms and conditions of this Agreement, for each calendar year this Agreement is in effect, LICENSEE shall pay to PRF an earned royalty calculated as a percentage of the Sales Value of Licensed Products made, used, sold or imported by LICENSEE, its sublicensees or its Affiliates in each country of the Territory in which there is (are) valid unexpired Patents. The royalties due hereunder shall be payable on a country-by-country basis in each country until the expiration of the last to expire of the Patents covering the Licensed Products or the manufacture use or sale of the Licensed Products in such country. The royalty percentage for therapeutic applications shall be [*] percent ([*]%) of the Sales Value of Licensed Products used or sold for sales up to [*] dollars, and [*] percent ([*]%) of the Sales Value of Licensed Products used or sold for sales in excess of [*] dollars. The royalty percentage for diagnostic applications shall be [*] percent ([*]%) of the Sales Value of Licensed Products used or sold for sales up to [*] dollars, and [*] percent ([*]%) of the Sales Value of Licensed Products used or sold for sales in excess of [*] dollars.
		

		
			 
		

		
			
		

		
			

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

		

		

			 

		

		

			 

		

		

			 

		

 

		

		
			 
		

		
			5.The following Patents are expressly added to Appendix A of the Agreement:
		

		
			 
		

			
					
						Purdue Reference Number

					
					
						Endocyte Matter 

					
						Number

					
					
						Application Number

					
					
						Filing Date

					
					
						Title

					
					
						Status

				
	
					
						64830-19

					
					
						3220C-222276

					
					
						13/580,436

					
					
						8/22/2012

					
					
						PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING

					
					
						Pending

				
	
					
						2014-LOW-

					
						66774-01

					
					
						3220C-

					
						227794

					
					
						61/909,822

					
					
						11/27/2013

					
					
						COMPOUNDS FOR POSITRON EMISSION TOMOGRAPHY

					
					
						Convert 

					
						11/27/2014

				

		
			 
		

		
			 
		

		
			6.All other terms and conditions of the Agreement remain unchanged and in effect.
		

		
			IN WITNESS WHEREOF, the parties have executed this AMENDMENT effective as of April 14, 2014.
		

		
			 
		

		
			Purdue Research FoundationEndocyte, Inc.
		

		
			 
		

		
			By:  /s/ Daniel J. Hasler          By:  /s/ P. Ron Ellis       
		

		
			 
		

		
			 
		

		 

		

			[*] = Indicates confidential information omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.

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