Document:

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                                                                  Exhibit 10.181

                              EMPLOYMENT AGREEMENT

         THIS AGREEMENT (the "Agreement"), is made and entered into effective
the 16/th/ day of May, 2002, by and between Pharmaceutical Product Development,
Inc. (the "Company"), a North Carolina corporation whose mailing address for
notice purposes is 3151 South Seventeenth Street, Wilmington, North Carolina
28412, Attention: Chief Executive Officer, and Linda Baddour ("Employee"), an
individual whose mailing address for notice purposes is 5208 Masonboro Harbor
Drive, Wilmington, North Carolina 28409.

                                    RECITALS

         A.   The Company is engaged in providing research and development
services to pharmaceutical and biotech companies and other entities (the
"Business").

         B.   The Company desires to employ Employee and Employee desires to be
employed by the Company, all upon the terms and conditions set forth herein.

         NOW, THEREFORE, in consideration of the foregoing recitals, the mutual
covenants of the parties hereinafter set forth and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereby agree as follows:

                                    ARTICLE 1
                              EMPLOYMENT AND DUTIES

         1.1  Engagement of Employee. The Company agrees to employ Employee and
Employee accepts such employment pursuant and subject to the terms and
conditions of this Agreement.

         1.2. Duties and Powers. During the Employment Period (as defined
herein), Employee shall serve as Chief Financial Officer of the Company and will
have such responsibilities, duties and authority, and will render such services
for and in connection with the Company and its affiliates as are customary in
such position and as the Board of Directors of the Company (the "Board") and the
Chief Executive Officer of the Company shall from time to time reasonably
direct. Employee shall devote Employee's full business time and attention
exclusively to the Business of the Company and shall use best efforts to
faithfully carry out Employee's duties and responsibilities hereunder. Employee
shall comply with all personnel policies and procedures of the Company as the
same now exist or may be hereafter implemented by the Company from time to time,
including those policies contained in the Pharmaceutical Product Development,
Inc. ("PPD") employee manual or handbook which sets forth policies and
procedures generally for employees of PPD and its subsidiaries and affiliates
(the "Handbook") to the extent not inconsistent with this Agreement.

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                                    ARTICLE 2
                               TERM OF EMPLOYMENT

         Unless sooner terminated as provided elsewhere in this Agreement,
Employee's employment under this Agreement shall commence on May 16, 2002 and
shall terminate at 11:59 p.m. on May 15, 2003 ("Initial Employment Period").
This Agreement automatically shall renew for successive one-year periods, unless
either the Company or Employee provides written notice to the other at least
sixty (60) days prior to the expiration of the then current Employment Period
(as hereinafter defined) stating said party's desire not to renew this
Agreement. The Initial Employment Period and any extension or renewal thereof
shall be referred to herein together as the "Employment Period". Notwithstanding
anything to the contrary contained herein, the Employment Period is subject to
termination pursuant to Article 4 hereof.

                                    ARTICLE 3
                            COMPENSATION AND BENEFITS

              3.1 Compensation. The Company will pay Employee a base salary at a
rate of $200,000.00 per annum (the "Base Salary"), payable in accordance with
the Company's regular payroll policy for salaried employees. The Base Salary of
Employee may be subject to increase annually during the Employment Period by the
Board of the Company. If the Employment Period is terminated pursuant to Article
4 hereof, then the Base Salary for any partial year will be prorated based on
the number of days elapsed in such year during which services were actually
performed by Employee.

              3.2 Benefits. During the Employment Period, Employee shall be
eligible to participate in and/or receive benefits under such employee and
welfare benefit plans as may be established from time to time by the Company,
including any profit-sharing, stock purchase, stock option, bonus, pension,
disability, group-term life insurance, health insurance and flexible benefit
payroll deduction plans, subject in each instance to Employee meeting all
eligibility and qualification requirements of such plans.

              3.3 Expenses. The Company will reimburse Employee, in accordance
with and subject to Employee's compliance with the Company's policy, for
Employee's necessary and reasonable out-of-pocket expenses incurred in the
course of performance of Employee's duties hereunder. All reimbursement of
expenses to Employee hereunder shall be conditioned upon presentation of
sufficient documentation evidencing such expenses.

              3.4 Vacation and Leave. Employee shall be entitled to the number
of days of "Paid Time Off" ("PTO") and other leave as may be established from
time to time by the Company for the benefit of its executive employees, subject
to Employee's compliance with the guidelines set forth in the Handbook.

                                        2

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              3.5 Working Facilities. The Company shall furnish Employee with
such office space, equipment, technical, secretarial and clerical assistance and
such other facilities, services and supplies as shall be reasonably necessary to
enable Employee to perform the duties required of Employee hereunder in an
efficient and professional manner.

                                    ARTICLE 4
                            TERMINATION OF EMPLOYMENT

              4.1 Basis for Termination. Notwithstanding any other provision in
this Agreement to the contrary, the Employment Period and Employee's employment
hereunder shall terminate effective on the date indicated upon the happening of
any of the following events:

                  a. Upon the death of Employee, effective immediately on the
date of death without any notice.

                  b. A determination by the Chief Executive Officer of the
Company, acting in good faith but made in the sole discretion of the Chief
Exeuctive Officer that Employee has failed to substantially perform her duties
under or otherwise breached any of the material terms of this Agreement,
effective upon the date said determination is communicated to Employee or such
later date, if any, as specified by the Chief Executive Officer of the Company.

                  c. A determination by the Chief Executive Officer of the
Company, acting in good faith but made in the sole discretion of the Chief
Executive Officer, that Employee (i) has become physically or mentally
incapacitated and is unable to perform her duties under this Agreement as a
result of such disability, which inability continues for a period of sixty (60)
days during any twelve-month period hereunder, (ii) has demonstrated gross
negligence or willful misconduct in the execution of her duties, or (iii) has
been convicted of a felony, effective upon the date said determination is
communicated to Employee or such later date, as specified by the Chief Executive
Officer of the Company.

              4.2 Compensation After Termination During Employment Period. If
the Company shall terminate Employee's employment during the Employment Period
pursuant to Section 4.1 hereof, the Company shall have no further obligations
hereunder or otherwise with respect to Employee's employment from and after the
termination or expiration date, except that the Company shall pay Employee's
Base Salary accrued through the date of termination or expiration and shall
provide such benefits as are required by applicable law. From and after such
termination or expiration date, the Company shall continue to have all other
rights available hereunder, including without limitation all rights under
Article 5 hereof, and at law or in equity.

                                        3

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                                    ARTICLE 5
                             PROPRIETARY INFORMATION

         Prior to or coincident with the commencement date hereof, Employee
shall execute in favor of the Company its standard Proprietary Information and
Inventions Agreement (the "Proprietary Agreement"), a copy of the form of which
is attached hereto as Annex A.

                                    ARTICLE 6
                                  MISCELLANEOUS

              6.1 Withholding Taxes. All amounts payable under this Agreement,
whether such payment is to be made in cash or other property, shall be subject
to withholding for Federal, state and local income taxes, employment and payroll
taxes, and other legally required withholding taxes and contributions to the
extent appropriate in the determination of the Company, and Employee shall
report all such amounts as ordinary income on Employee's personal income returns
and for all other purposes.

              6.2 Assignment. No party hereto may assign or delegate any of its
rights or obligations hereunder without the prior written consent of the other
party hereto; provided, however, that the Company shall have the right to assign
all or any part of its rights and obligations under this Agreement (i) to any
subsidiary or affiliate of the Company or any surviving entity following any
merger or consolidation of any of those entities with any entity other than the
Company, or (ii) in connection with the sale of the Business by the Company.

              6.3 Binding Effect. Except as otherwise expressly provided herein,
all covenants and agreements contained in this Agreement by or on behalf of any
of the parties hereto shall be binding upon and inure to the benefit of the
respective legal representatives, heirs, successors and permitted assigns of the
parties hereto.

              6.4 Entire Agreement. Except as otherwise expressly set forth
herein, this Agreement sets forth the entire understanding of the parties and
supersedes and preempts all prior oral or written understandings and agreements
with respect to the subject matter hereof.

              6.5 Severability. Whenever possible, each provision of this
Agreement shall be interpreted in such manner as to be effective and valid under
applicable law, but if any provision of this Agreement is held to be prohibited
by or invalid under applicable law, such provision shall be ineffective only to
the extent of such prohibition or invalidity, without invalidating the remainder
of this Agreement.

              6.6 Amendment; Modification. No amendment or modification of this
Agreement and no waiver by any party of the breach of any covenant contained
herein

                                        4

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shall be binding unless executed in writing by the party against whom
enforcement of such amendment, modification or waiver is sought. No waiver shall
be deemed a continuing waiver or a waiver in respect of any subsequent breach or
default, either of a similar or different nature, unless expressly so stated in
writing.

              6.7  Governing Law. This Agreement shall be governed by and
construed and enforced in accordance with the laws of the State of North
Carolina, without giving effect to provisions thereof regarding conflict of
laws.

              6.8  Arbitration. Any dispute, controversy or claim arising out of
or relating to this Agreement, including but not limited to its existence,
validity, interpretation, performance or non-performance or breach, shall be
decided by a single neutral arbitrator agreed upon by the parties hereto in
Wilmington, North Carolina in binding arbitration pursuant to the commercial
arbitration rules of the American Arbitration Association then in effect. The
parties to any such arbitration shall be limited to the parties to this
Agreement or any successor thereof. The written decision of the arbitrator shall
be final and binding and may be entered and enforced in any court of competent
jurisdiction. Each party waives any right to a jury trial in any such forum.
Each party to the arbitration shall pay its fees and expenses, unless otherwise
determined by the arbitrator.

              6.9  Notices. All notices, demands or other communications to be
given or delivered hereunder or by reason of the provisions of this Agreement
shall be in writing and shall be deemed to have been properly served if (a)
delivered personally, (b) delivered by a recognized overnight courier service,
(c) sent by certified mail, return receipt requested and first class postage
prepaid, or (d) sent by facsimile transmission followed by a confirmation copy
delivered by a recognized overnight courier service the next day. Such notices,
demands and other communications shall be sent to the address first set forth
above, or to such other address or to the attention of such other person as the
recipient party has specified by prior written notice to the sending party. Date
of service of such notice shall be (i) the date such notice is personally
delivered or sent by facsimile transmission (with issuance by the transmitting
machine of a confirmation of successful transmission), (ii) the date of receipt
if sent by certified mail, or (iii) the date of receipt if sent by overnight
courier.

              6.10 Counterparts. This Agreement may be executed in multiple
counterparts, each of which shall be deemed an original and all of which taken
together shall constitute one and the same Agreement.

              6.11 Descriptive Heading; Interpretation. The descriptive headings
in this Agreement are inserted for convenience of reference only and are not
intended to be part of or to affect the meaning or interpretation of this
Agreement.

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         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the day and year first above written.

             COMPANY:                   Pharmaceutical Product Development, Inc.

                                        By: /s/ Fred B. Davenport, Jr.
                                        -----------------------------------
                                            Fred B. Davenport, Jr.
                                            President

             EMPLOYEE:

                                        By: /s/ Linda Baddour
                                            --------------------------------
                                            Linda Baddour

                                        6<PAGE>

                                                                  Exhibit 10.182

                              EMPLOYMENT AGREEMENT

                  THIS EMPLOYMENT AGREEMENT (hereinafter the "Agreement"), made
this 1/st/ day of May, 2002 (the "Effective Date"), by and between PPD
Development, LP, a Texas limited partnership (hereinafter "PPD Development"),
and W. Richard Staub (hereinafter "Employee").

                                    RECITALS:

                  A.   Employee desires employment upon the terms and conditions
herein stated.

                  B.   PPD Development desires to employ Employee upon the terms
and conditions herein stated.

                  C.   Employee and PPD Development desire to embody in writing
the terms and conditions of such employment in this Agreement.

                  NOW, THEREFORE, in consideration of the mutual promises,
covenants and considerations contained herein, and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereby agree as follows:

                  1.   Employment. PPD Development hereby employs Employee and
Employee hereby accepts such employment on a full time basis as Senior Vice
President - Global Business Development upon the terms and conditions
hereinafter set forth.

                  2.   Term. The term of this Agreement shall begin on the
Effective Date and shall end on December 31, 2002, unless sooner terminated as
provided herein. Thereafter, this Agreement shall be automatically renewed for
successive one-year terms upon the terms and conditions herein set forth except
for (a) salary adjustments as provided for in Section 9 below and (b) new bonus
plans as provided in Section 3 below, unless either party gives notice as herein
provided to the other of said party's intent not renew this Agreement not less
than 60 days prior to the expiration of the then current term of this Agreement.

                  3.   Salary. For all services rendered by Employee under this
Agreement, PPD Development shall pay to Employee for the initial term hereof a
monthly salary of $13,750. Employee shall also be entitled to a Quarterly Bonus
if the Businesses (as hereinafter defined) attain a certain level of
Authorizations for the applicable calendar quarter of the initial term hereof,
as set forth in Appendix I (effective May 1, 2002) attached. Each Quarterly
Bonus, if any, to which Employee is entitled shall be paid within thirty (30)
days after its determination. Employee shall also be entitled to a Plan Bonus as
provided for in Appendix I (effective May 1, 2002) attached, which Plan Bonus
shall be paid to Employee at the same time annual bonuses, if any, for the
initial

<PAGE>

term are or would have been paid to other senior executives of PPD Development.
In addition, Employee shall be entitled to an award of non-qualified stock
options under the Pharmaceutical Product Development, Inc. ("PPD") Equity
Compensation Plan if Authorizations for the Businesses attain specified
percentages of the Annual Target for the initial term hereof as set forth in
Appendix I (effective May 1, 2002). Any such award of stock options for the
initial term shall have an exercise price equal to the NASDAQ closing price on
December 31, 2002, and shall contain such other terms and conditions, including
a three-year linear vesting schedule, as included in stock option awards
generally for other senior executives of PPD Development. As a condition to PPD
Development's obligation to pay the bonuses provided for under this Section 3,
Employee must be employed by PPD Development under and pursuant to the terms and
conditions of this Agreement on the date on which such bonus is due and payable.
A new bonus plan shall be agreed upon by Employee and PPD Development for each
one-year renewal term of this Agreement.

                  4.   Duties. Employee shall have overall responsibility for
business development of (a) PPD Development and all of its subsidiaries as of
the Effective Date, except Pharmaco Investments, Inc., (b) PPD Global Ltd., (c)
Leicester Clinical Research Centre Ltd. and (d) Chelmsford Clinical Trials Unit
Ltd., (e) Piedmont Research Center, Inc., (f) Medical Research Laboratories
International, LLC, (g) Medical Research Laboratories International, BVBA and
(g) PPD Discovery, Inc. (collectively, the "Businesses"). Employee's duties
shall include but not be limited to supervision of the Businesses' sales and
bids and contracts divisions. Employee shall carry out his duties and
responsibilities under the general supervision of the Chief Executive Officer of
PPD. Employee shall undertake such travel as may be required to perform the
duties prescribed herein. During the term of this Agreement, Employee shall
devote substantially all of his working time, attention and energies to the
business of PPD Development and shall perform such other duties as reasonably
requested from time to time by the Chief Executive Officer of PPD.

                  5.   Working Facilities. PPD Development shall furnish
Employee with office space, equipment, technical, secretarial and clerical
assistance and such other facilities, services, support and supplies as may be
reasonably needed to perform the duties herein prescribed in an efficient and
professional manner.

                  6.   Non-Compete. During the term of this Agreement, Employee
hereby agrees that he shall not (a) become an officer, employee, director,
agent, representative, member, associate or consultant of or to a corporation,
partnership or other business entity or person, (b) directly or indirectly
acquire a proprietary interest in a corporation, partnership or other business
entity or person, or (c) directly or indirectly own any stock in a corporation
(other than a publicly traded corporation of which Employee owns less than five
percent (5%) of the outstanding stock) which is engaged in the business of
managing clinical research programs for pharmaceutical and medical products or
in any other business which is developed by PPD Development during the term of
this Agreement anywhere in the United States (whether or not such business is
physically

<PAGE>

located within the United States). The parties agree that the business and
operations of PPD Development are national in scope. For that reason, the
parties agree that a geographical limitation on the foregoing covenant is not
appropriate.

                  7.   Termination. Notwithstanding any other provision in this
Agreement to the contrary, this Agreement and Employee's employment hereunder
shall terminate effective upon the date indicated upon the occurrence of any of
the following events:

                       a.  Death of Employee, effective immediately on the date
of death without any notice.

                       b.  A determination  by the Chief  Executive  Officer of
PPD, acting in good faith but made in the sole discretion of the Chief Executive
Officer, that Employee has failed to substantially perform his duties under or
otherwise breached any of the material terms of this Agreement, effective upon
the date said determination is communicated to Employee or such later date, if
any, as specified by the Chief Executive Officer of PPD.

                       c.  A determination by the Chief Executive Officer of
PPD, acting in good faith but made in the sole discretion of the Chief Executive
Officer, that Employee (i) has become physically or mentally incapacitated and
is unable to perform his duties under this Agreement as a result of such
disability, which inability continues for a period of sixty (60) consecutive
calendar days, (ii) has breached any of the material terms of this Agreement,
including failure to meet Quarterly Targets as set forth in Appendix I attached,
(iii) has demonstrated gross negligence or willful misconduct in the execution
of his duties, or (iv) has been convicted of a felony, effective upon the date
said determination is communicated to Employee or such later date, as specified
by the Chief Executive Officer of PPD.

                  8.   Disclosure of Information. Prior to or coincident with
the commencement of the date hereof, Employee shall execute in favor of PPD
Development its standard Proprietary Information and Inventions Agreement, a
copy of which is attached hereto as Annex A.

                  9.   Benefits. During the term hereof, Employee shall be
entitled to participate in all benefits provided by PPD Development to its
employees generally, including but not limited to health insurance, disability
insurance and retirement plans, all of which are currently provided to employees
of PPD Development, subject to the eligibility requirements of any plan(s)
establishing same. Employee shall be subject to PPD Development's policies
applicable to other executive employees of PPD Development with respect to
periodic reviews and adjustments in salary, and shall be considered for and
eligible to participate in benefits, if any, provided generally by PPD
Development to its executive employees, including but not limited to issuance of
stock options, cash bonuses, etc., to the extent such stock options, bonuses,
etc., are not otherwise provided for herein (including in Appendix I), in
connection with Employee's

<PAGE>

duties and performance as an executive employee. Employee shall be entitled to
four (4) weeks paid vacation during each year.

                  10.  Expenses. PPD Development will reimburse Employee, in
accordance with and subject to Employee's compliance with PPD Development's
policy, for Employee's necessary and reasonable out-of-pocket expenses incurred
in the course of performance of Employee's duties hereunder. All reimbursement
of expenses to Employee hereunder shall be conditioned upon presentation of
sufficient documentation evidencing such expenses.

                  11.  Remedies. In the event of Employee's actual or threatened
breach of the provisions of Section 6 of this Agreement, PPD Development shall
be entitled to a temporary restraining order and/or permanent injunction
restraining Employee from such breach. Nothing herein shall be construed as
preventing PPD Development from pursuing any other available remedies for such
breach or threatened breach, including recovery of damages from Employee and
from any corporation, partnership or other business entity or person with which
the Employee has entered or attempted to enter into a relationship.

                  12.  Entire Agreement. This Agreement constitutes the entire
agreement between the parties with respect to the subject matter hereof and may
not be altered or amended except by agreement in writing signed by the parties.

                  13.  Waiver of Breach. Waiver by either party of a breach of
any provision of this Agreement by the other party shall not operate as a waiver
of any subsequent breach by the other party. No waiver shall be valid unless in
writing and signed by the party against whom the waiver is sought.

                  14.  Severability. If any portion of this Agreement shall be
declared invalid by a court of competent jurisdiction, the remaining portion
shall continue in full force and effect as if this Agreement has been executed
with the invalid portion eliminated and this Agreement shall be so construed.

                  15.  Benefit. This Agreement shall inure to the benefit of and
be binding upon PPD Development, its successors and assigns, and Employee, his
heirs, successors, assigns and personal representatives.

                  16.  Applicable Law. This Agreement shall be governed by the
laws of the State of North Carolina.

                  17.  Assignment. Neither party may assign his or its rights or
obligations hereunder without the prior written consent of the other.

                  18.  Notice. All notices, demands or other communications to
be given or delivered hereunder or by reason of the provisions of this Agreement
shall be in writing

<PAGE>

and shall be deemed to have been properly served if (a) delivered personally,
(b) delivered by a recognized overnight courier service, (c) sent by certified
mail, return receipt requested and first class postage prepaid, or (d) sent by
facsimile transmission followed by a confirmation copy delivered by a recognized
overnight courier service the next day. Date of service of such notice shall be
(i) the date such notice is personally delivered or sent by facsimile
transmission (with issuance by the transmitting machine of a confirmation of
successful transmission), (ii) the date of receipt if sent by certified mail, or
(iii) the date of receipt if sent by overnight courier. Such notices, demands
and other communications shall be sent to the address set forth below, or to
such other address or to the attention of such other person as the recipient
party has specified by prior written notice to the sending party:

                  If to PPD Development, then to

                  PPD Development, LP
                  3151 South 17/th/ Street
                  Wilmington, NC 28412
                  Attn: Chief Executive Officer
                  Facsimile: (910) 772-6951

                  If to Employee, then to:

                  W. Richard Staub
                  3900 Paramount Parkway
                  Morrisville, NC  27560
                  Facsimile: (919) 462-4297

                  19.  Arbitration. Except for disputes, controversies, breaches
or claims directly or indirectly related to Sections 6 and the rights to pursue
remedies as set forth in Section 11, any dispute, controversy or claim arising
out of or relating to this Agreement, including but not limited to any breach,
or as to its existence, validity, interpretation, performance or
non-performance, or damages, including claims in tort, shall be decided by a
single neutral arbitrator in Wilmington, North Carolina in binding arbitration
pursuant to the Employment Arbitration Rules of the American Arbitration
Association then in effect. The parties to any such arbitration shall be limited
to the parties to this Agreement or any successor thereof. The arbitration shall
be conducted in accordance with the procedural laws of the United States Federal
Arbitration Act, as amended. The written decision of the arbitrator shall be
final and binding, and may be entered and enforced in any court of competent
jurisdiction and each party specifically acknowledges and agrees to waive any
right to a jury trial in any such forum. Each party to the arbitration shall pay
its fees and expenses, unless otherwise determined by the arbitrator.

                  20.  Counterparts. This Agreement may be executed in multiple
counterparts, each of which shall be deemed an original and all of which taken
together shall constitute one and the same agreement.

<PAGE>

                  21.  Descriptive Headings: Interpretation. The descriptive
headings in this Agreement are inserted for convenience of reference only and
are not intended to be part of or to affect the meaning or interpretation of
this Agreement.

                  IN WITNESS WHEREOF, the parties have caused this Agreement to
be executed as of the date first hereinabove set forth.

                                      PPD DEVELOPMENT, LP

                                      By: PPD GP, LLC
                                          Its General Partner

                                      By: /s/ Fred B. Davenport, Jr.
                                          --------------------------------------
                                      Name:  Fred B. Davenport, Jr.
                                             -----------------------------------
                                      Title: Vice President
                                             -----------------------------------

                                      /s/ W. Richard Staub                (SEAL)
                                      ----------------------------------
                                      W. Richard Staub

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