Document:

Exhibit
4.4

MEDIMMUNE,
INC.

Certificate No. A-1

THIS SECURITY IS A GLOBAL
SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS
REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY OR A
SUCCESSOR DEPOSITARY.  THIS SECURITY IS
NOT EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN
THE DEPOSITARY OR ITS NOMINEE EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN
THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS
SECURITY AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A
NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE
DEPOSITARY) MAY BE REGISTERED EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN
THE INDENTURE.

UNLESS THIS CERTIFICATE
IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A
NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF
TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE
NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH
OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY
TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON
IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN
INTEREST HEREIN.

TRANSFERS OF THIS GLOBAL
SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES
OF CEDE & CO. OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND
TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS
MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN SECTION 2.16 OF THE
INDENTURE.

 

1.375%
Convertible Senior Note due 2011

Certificate No. A-1

CUSIP No.
584699 AG7

MedImmune, Inc., a
Delaware corporation (the “Company”), for
value received, hereby promises to pay to Cede & Co., or its registered
assigns, the principal sum of five hundred million dollars ($500,000,000) on
July 15, 2011 and to pay interest thereon, as provided on the reverse hereof,
until the principal and any unpaid and accrued interest are paid or duly
provided for.

Interest Payment Dates:
January 15 and July 15, with the first payment to be made on January 15, 2007.

Record Dates: January 1
and July 1.

The provisions on the
back of this certificate are incorporated as if set forth on the face hereof.

 

IN WITNESS WHEREOF,
MedImmune, Inc. has caused this instrument to be duly signed.

	
  

  	
   

  	
  MEDIMMUNE, INC.

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:

  	
   

  
	
   

  	
   

  	
   

  	
  Name:

  	
   

  
	
   

  	
   

  	
   

  	
  Title:

  	
   

  

Dated: September __, 2006

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

This is one of the Securities referred to 

in the within-mentioned Indenture.

	
  THE BANK OF NEW YORK, as Trustee

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  By:

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Authorized
  Signatory

  	
   

  	
   

  

 

Dated: September
__, 2006

 

Exhibit
4.4

[REVERSE OF SECURITY]

MEDIMMUNE, INC.

1.375% Convertible Senior Note due 2011

1.             Interest.  MedImmune, Inc., a Delaware corporation (the “Company”), promises to pay interest on the principal amount
of this Security at the rate per annum shown
above.  The Company will pay interest,
payable semi-annually in arrears, on January 15 and July 15 of each year, with
the first payment to be made on January 15, 2007.  Interest on the Securities will accrue on the
principal amount from, and including, the most recent date to which interest
has been paid or provided for or, if no interest has been paid, from, and
including, June 28, 2006, in each case to, but excluding, the next interest
payment date or Maturity Date, as the case may be.  Interest will be computed on the basis of a
360-day year of twelve 30-day months.

2.             Maturity.  The Securities will mature on July 15, 2011.

3.             Method of
Payment.  Except as provided
in the Indenture (as defined below), the Company will pay interest on the
Securities to the persons who are Holders of record of Securities at the close
of business on the record date set forth on the face of this Security next
preceding the applicable interest payment date. 
Holders must surrender Securities to a Paying Agent to collect the principal
amount or Fundamental Change Repurchase Price of the Securities, plus, if
applicable, accrued and unpaid interest, if any, payable as herein provided on
the Maturity Date or upon Repurchase Upon Fundamental Change, as the case may
be.  The Company will pay, in money of
the United States that at the time of payment is legal tender for payment of
public and private debts, all amounts due in cash with respect to the
Securities, which amounts shall be paid (A) in the case this Security is in
global form, by wire transfer of immediately available funds to the account
designated by the Depositary or its nominee; (B) in the case this Security is
held, other than global form, by a Holder of more than five million dollars
($5,000,000) in aggregate principal amount of Securities, by wire transfer of
immediately available funds to the account specified by such Holder or, if such
Holder does not specify an account, by mailing a check to the address of such
Holder set forth in the register of the Registrar; and (C) in the case this
Security is held, other than global form, by a Holder of five million dollars
($5,000,000) or less in aggregate principal amount of Securities, by mailing a
check to the address of such Holder set forth in the register of the Registrar.

4.             Paying
Agent, Registrar, Conversion Agent. 
Initially, The Bank of New York (the “Trustee”)
will act as Paying Agent, Registrar, Bid Solicitation Agent and Conversion
Agent.  The Company may change any Paying
Agent, Registrar, Bid Solicitation Agent or Conversion Agent without prior
notice.

5.             Indenture.  The Company issued the Securities under an
Indenture dated as of June 28, 2006 (the “Indenture”)
between the Company and the Trustee.  The
terms of the Securities include those stated in the Indenture and those made
part of the Indenture by reference to the Trust Indenture Act of 1939 (15 U.S.
Code §§ 77aaa-77bbbb) (the “TIA”) as
amended and in effect from time to time. 
The Securities are subject to all such terms, and Holders are referred
to the Indenture and the TIA for a statement of such terms.  The Securities are general unsecured 

 1
 

 

senior obligations of the Company limited to
$500,000,000 aggregate principal amount ($575,000,000 if the Initial Purchasers
have elected to exercise in full the Option to purchase up to an additional
$75,000,000 aggregate principal amount of the Securities), except as otherwise
provided in the Indenture (except for Securities issued in substitution for
destroyed, mutilated, lost or stolen Securities).  Terms used herein without definition and
which are defined in the Indenture have the meanings assigned to them in the
Indenture.

6.             No Optional
Redemption.

Prior to maturity, the
Securities shall not be subject to redemption at the option of the Company.

7.             Repurchase
at Option of Holder Upon a Fundamental Change.  Subject to the terms and conditions of the
Indenture, in the event of a Fundamental Change, each Holder of the Securities
shall have the right, at the Holder’s option, to require the Company to
repurchase such Holder’s Securities including any portion thereof which is
$1,000 in principal amount or any integral multiple thereof on a date selected
by the Company (the “Fundamental Change
Repurchase Date”), which date is no later than thirty five (35)
days, nor earlier than twenty (20) days, after the date on which notice of such
Fundamental Change is mailed in accordance with the Indenture, at a price
payable in cash equal to one hundred percent (100%) of the principal amount of
such Security, plus accrued and unpaid interest to, but excluding, the
Fundamental Change Repurchase Date; provided, however, that if such Fundamental Change Repurchase Date is
after a record date for the payment of an installment of interest and on or
before the related interest payment date, then the accrued and unpaid interest,
if any, to, but excluding, such interest payment date will be paid on such
interest payment date to the Holder of record of such Securities at the close
of business on such record date, and the Holder surrendering such Securities
for repurchase will not be entitled to any such accrued and unpaid interest
unless such Holder was also the Holder of record of such Securities at the
close of business on such record date.

8.             Conversion.

The Securities
shall be convertible into cash, and if applicable, shares of Common Stock if
and to the extent the conditions therefor specified the Indenture are
satisfied.

To convert a
Security, a Holder must (1) complete and sign the Conversion Notice, with
appropriate signature guarantee, on the back of the Security, (2) surrender the
Security to a Conversion Agent, (3) furnish appropriate endorsements and
transfer documents if required by the Registrar or Conversion Agent, (4) pay
the amount of interest, if any, the Holder must pay in accordance with the
Indenture and (5) pay any tax or duty if required pursuant to the
Indenture.  A Holder may convert a
portion of a Security if the portion is $1,000 principal amount or an integral
multiple of $1,000 principal amount.

Notwithstanding anything herein to the contrary, no
Security may be converted after the close of business on the Business Day
immediately preceding the Maturity Date.

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Upon conversion of a
Security, the Holder thereof shall be entitled to receive the cash and, if
applicable, shares of Common Stock payable upon conversion in accordance with Article X of the Indenture.

The initial Conversion
Rate is 29.9679 shares of Common Stock per $1,000 principal amount of
Securities (which results in an effective initial Conversion Price of approximately
$33.37 per share) subject to adjustment in the event of certain circumstances
as specified in the Indenture.  The
Company will deliver cash in lieu of any fractional share.

The Conversion Rate
applicable to each Security that is surrendered for conversion, in accordance
with the Securities and Article X of
the Indenture, at any time during the Make-Whole Conversion Period with respect
to a Make-Whole Fundamental Change shall be increased to an amount equal to the Conversion Rate that would,
but for Section 10.14 of the Indenture, otherwise apply to
such Security pursuant to Article X of
the Indenture, plus an amount
equal to the Make-Whole Applicable Increase; provided, however,
that such increase to the Conversion Rate shall not apply if such Make-Whole
Fundamental Change is announced by the Company but shall not be consummated.

9.             Denominations,
Transfer, Exchange.  The
Securities are in registered form, without coupons, in denominations of $1,000
principal amount and integral multiples of $1,000 principal amount.  The transfer of Securities may be registered
and Securities may be exchanged as provided in the Indenture.  The Registrar may require a Holder, among
other things, to furnish appropriate endorsements and transfer documents.  No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a
sum sufficient to cover any tax or similar governmental charge that may be
imposed in connection with certain transfers or exchanges.  The Company or the Trustee, as the case may
be, shall not be required to register the transfer of or exchange any Security
for which a Purchase Notice has been delivered, and not withdrawn, in
accordance with the Indenture, except the unrepurchased portion of Securities
being repurchased in part.

10.           Persons Deemed Owners.  The registered Holder of a Security may be
treated as the owner of such Security for all purposes.

11.           Merger or Consolidation.  The Company shall not consolidate with, or
merge with or into, or sell, transfer, lease, convey or otherwise dispose of
all or substantially all of the property or assets of the Company to, another
person, whether in a single transaction or series of related transactions,
unless (i) such other person is a corporation, limited liability company,
partnership, trust or other entity organized and existing under the laws of the
United States, any State thereof, the District of Columbia or any foreign
country; (ii) such person assumes by supplemental indenture all the obligations
of the Company under the Securities and the Indenture; and (iii) immediately
after giving effect to the transaction, no Default or Event of Default shall
exist.

12.           Amendments, Supplements
and Waivers.  Subject to
certain exceptions, the Indenture or the Securities may be amended or
supplemented with the consent of the Holders of at least a majority in
aggregate principal amount of the outstanding Securities, and certain existing
Defaults or Events of Default may be waived with the consent of the Holders of
a 

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majority in aggregate principal amount of the
Securities then outstanding.  In
accordance with the terms of the Indenture, the Company, with the consent of
the Trustee, may amend or supplement this Indenture or the Securities without
notice to or the consent of any Securityholder: (i) to comply with Sections  5.01 and 10.11 of the Indenture; (ii) to make any changes or
modifications to the Indenture necessary in connection with the registration of
the Securities under the Securities Act pursuant to the Registration Rights
Agreement or the qualification of the Indenture under the TIA; (iii) to secure
the obligations of the Company in respect of the Securities; (iv) to add to the
covenants of the Company described in the Indenture for the benefit of Securityholders
or to surrender any right or power conferred upon the Company; and (v) to make
provisions with respect to adjustments to the Conversion Rate as required by
the Indenture or to increase the Conversion Rate in accordance with the
Indenture.  In addition, the Company and
the Trustee may enter into a supplemental indenture without the consent of
Holders of the Securities to (i) cure any ambiguity, defect, omission or
inconsistency in the Indenture in a manner that does not, individually or in
the aggregate with all other changes, adversely affect the rights of any Holder
in any material respect or (ii) conform the Indenture or the Securities to the
description thereof contained in the Offering Memorandum under the caption “Description
of notes.”

13.           Defaults and Remedies.

If an Event of Default
(excluding an Event of Default specified in Section
6.01(viii) or (ix)
of the Indenture with respect to the Company (but including an Event of Default
specified in Section 6.01(viii) or (ix) of the Indenture solely with respect to a Significant
Subsidiary of the Company or any group of Subsidiaries that in the aggregate
would constitute a Significant Subsidiary of the Company)) occurs and is
continuing, the Trustee by notice to the Company or the Holders of at least
twenty five percent (25%) in principal amount of the Securities then outstanding
by notice to the Company and the Trustee may declare the Securities to be due
and payable.  Upon such declaration, the
principal of, and any premium and accrued and unpaid interest (including any
additional interest) on, all Securities shall be due and payable
immediately.  If an Event of Default
specified in Section  6.01(viii) or (ix) of the Indenture with respect to the Company
(excluding, for purposes of this sentence, an Event of Default specified in Section  6.01(viii) or (ix) of the Indenture solely with respect to a Significant
Subsidiary of the Company or any group of Subsidiaries that in the aggregate
would constitute a Significant Subsidiary of the Company) occurs, the principal
of, and premium and accrued and unpaid interest (including any additional
interest) on, all the Securities shall ipso facto become
and be immediately due and payable without any declaration or other act on the
part of the Trustee or any Holder.  The
Holders of a majority in aggregate principal amount of the Securities then
outstanding by written notice to the Trustee may rescind or annul an
acceleration and its consequences if (A) the rescission would not conflict with
any order or decree, (B) all existing Events of Default, except the nonpayment
of principal, premium or interest (including additional interest) that has
become due solely because of the acceleration, have been cured or waived and
(C) all amounts due to the Trustee under Section 7.07 of
the Indenture have been paid.

Holders may not enforce
the Indenture or the Securities except as provided in the Indenture.  The Holders of a majority in aggregate
principal amount of the Securities then outstanding may direct the time, method
and place of conducting any proceeding for any remedy available to the Trustee
or exercising any trust or power conferred on it.  However, the Trustee 

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may refuse to follow any direction that conflicts with
law or the Indenture, is unduly prejudicial to the rights of other Holders or
would involve the Trustee in personal liability unless the Trustee is offered
indemnity reasonably satisfactory to it; provided, that
the Trustee may take any other action deemed proper by the Trustee which is not
inconsistent with such direction.

If a Default or Event of
Default occurs and is continuing as to which the Trustee has received written
notice pursuant to the provisions of the Indenture, or as to which a
Responsible Officer of the Trustee shall have actual knowledge, the Trustee
shall mail to each Holder a notice of the Default or Event of Default within
thirty (30) days after it occurs unless such Default or Event of Default has
been cured or waived.  Except in the case
of a Default or Event of Default in payment of any amounts due with respect to
any Security, the Trustee may withhold the notice if, and so long as it in good
faith determines that, withholding the notice is in the best interests of
Holders.  The Company must deliver to the
Trustee an annual compliance certificate.

14.           Trustee Dealings with the
Company.  The Trustee under
the Indenture, or any banking institution serving as successor Trustee
thereunder, in its individual or any other capacity, may make loans to, accept
deposits from, and perform services for, the Company or its Affiliates, and may
otherwise deal with the Company or its Affiliates, as if it were not Trustee.

15.           No Recourse Against Others.  No past, present or future director, officer,
employee or stockholder, as such, of the Company shall have any liability for
any obligations of the Company under the Securities or the Indenture or for any
claim based on, in respect of, or by reason of, such obligations or their
creation.  Each Holder, by accepting a
Security, waives and releases all such liability.  The waiver and release are part of the
consideration for the issue of the Securities.

16.           Authentication.  This Security shall not be valid until
authenticated by the manual signature of the Trustee or an authenticating agent
in accordance with the Indenture.

17.           Abbreviations.  Customary abbreviations may be used in the
name of a Holder or an assignee, such as: TEN COM (= tenants in common), TEN
ENT (= tenants by the entirety), JT TEN (= joint tenants with right of
survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A
(Uniform Gifts to Minors Act).

THE COMPANY WILL FURNISH
TO ANY HOLDER UPON WRITTEN REQUEST AND WITHOUT CHARGE A COPY OF THE
INDENTURE.  REQUESTS MAY BE MADE TO:

MedImmune, Inc.

One MedImmune Way

Gaithersburg, MD 20878

Attn: General Counsel

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Exhibit
4.4

[FORM OF ASSIGNMENT]

	
  

  	
   

  	
   

  
	
  I or we assign to

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING
  NUMBER

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  
	
  (please print or type name and address)

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  the within Security and all rights thereunder, and
  hereby irrevocably constitute and appoint

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  Attorney to transfer the Security on the books of
  the Company with full power of substitution in the premises.

  
	
   

  	
   

  	
   

  

 

	
  

  	
   

  	
   

  	
   

  	
   

  
	
  Dated: 

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  NOTICE: The signature on this assignment must
  correspond with the name as it appears upon the face of the within Security
  in every particular without alteration or enlargement or any change
  whatsoever and be guaranteed by a guarantor institution participating in the
  Securities Transfer Agents Medallion Program or in such other guarantee
  program acceptable to the Registrar.

  

 

	
  Signature Guarantee:

  	
   

  	
   

  

 

 

In connection with any
transfer of this Security occurring prior to the date which is the earlier of
(i) the date of the declaration by the SEC of the effectiveness of a
registration statement under the Securities Act of 1933, as amended, covering
resales of this Security (which effectiveness shall not have been suspended or
terminated at the date of the transfer) and (ii) the Resale Restriction
Termination Date, the undersigned confirms that it is making, and it has not
utilized any general solicitation or general advertising in connection with,
the transfer:

[Check One]

	
  (1)

  	
   

  	
  ____

  	
   

  	
  to the Company or any Subsidiary thereof, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (2)

  	
   

  	
  ____

  	
   

  	
  pursuant to, and in compliance with, the exemption
  from registration provided by Rule 144A under the Securities Act of 1933, as
  amended, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (3)

  	
   

  	
  ____

  	
   

  	
  pursuant to, and in compliance with, the exemption
  from registration provided by Rule 144 under the Securities Act of 1933, as
  amended, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (4)

  	
   

  	
  ____

  	
   

  	
  pursuant to, and in compliance with, an exemption
  from registration under the Securities Act of 1933, as amended, other than
  Rule 144A or Rule 144, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (5)

  	
   

  	
  ____

  	
   

  	
  pursuant to an effective registration statement
  under the Securities Act of 1933, as amended.

  

 

Unless one of the
items (1) through (5) is checked, the Registrar will refuse to register any of
the Securities evidenced by this certificate in the name of any person other
than the registered Holder thereof; provided, however, that if item (3) or (4) is checked, the Company or
the Registrar may require, prior to registering any such transfer of the
Securities, in their sole discretion, such written legal opinions,
certifications and other information as the Registrar or the Company have
reasonably requested to confirm that such transfer is being made pursuant to an
exemption from, or in a transaction not subject to, the registration
requirements of the Securities Act of 1933, as amended.  If item (2) is checked, the purchaser must
complete the certification below.

If none of the
foregoing items are checked, the Trustee or Registrar shall not be obligated to
register this Security in the name of any person other than the Holder hereof
unless and until the conditions to any such transfer of registration set forth
herein and in the Indenture shall have been satisfied.

	
  Dated:

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  Signed:

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  (Sign exactly as name appears on the other side of
  this Security)

  

 

	
  Signature Guarantee:

  	
   

  	
   

  

 

 

TO BE COMPLETED BY PURCHASER IF (2) ABOVE IS CHECKED

The undersigned represents and warrants that it is
purchasing this Security for its own account or an account with respect to
which it exercises sole investment discretion and that it and any such account
is a “qualified institutional buyer” within the meaning of Rule 144A under the
Securities Act of 1933, as amended, and is aware that the sale to it is being
made in reliance on Rule 144A and acknowledges that it has received such
information regarding the Company as the undersigned has requested pursuant to
Rule 144A and acknowledges that the transferor is relying upon the undersigned’s
foregoing representations in order to claim the exemption from registration
provided by Rule 144A.

	
  Dated:

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  NOTICE:

  	
   

  	
  To be executed by an executive officer

  

 

 

CONVERSION NOTICE

To convert this Security in accordance with the
Indenture, check the box:  o

To convert only part of this Security, state the
principal amount to be converted (must be in multiples of $1,000):

$                             

If you want the stock certificate representing the
shares of Common Stock, if any, issuable upon conversion made out in another
person’s name, fill in the form below:

	
  

  
	
  (Insert other person’s soc.
  sec. or tax I.D. no.)

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
  (Print or type
  other person’s name, address and zip code)

  
	
   

  
	
   

  

 

	
  Date:

  	
   

  	
   

  	
   

  	
  Signature(s):

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  (Sign exactly as your name(s) appear(s) on the other
  side of this Security)

  

 

	
  Signature(s) guaranteed by:

  	
   

  	
   

  
	
   

  	
   

  	
  (All signatures must be guaranteed by a guarantor
  institution participating in the Securities Transfer Agents Medallion Program
  or in such other guarantee program acceptable to the Trustee.)

  

 

 

PURCHASE NOTICE

Certificate No. of Security:  ___________

If you want to elect to
have this Security purchased by the Company pursuant to Section
3.02 of the Indenture, check the box:  o

If you want to elect to
have only part of this Security purchased by the Company pursuant to Section 3.02 of the Indenture, state the principal amount to
be so purchased by the Company:

$                                                                        

(in an integral multiple of $1,000)

	
  Date:

  	
   

  	
   

  	
   

  	
  Signature(s):

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  (Sign exactly as your name(s) appear(s) on the other
  side of this Security)

  

 

	
  Signature(s) guaranteed by:

  	
   

  	
   

  
	
   

  	
   

  	
  (All signatures must be guaranteed by a guarantor
  institution participating in the Securities Transfer Agents Medallion Program
  or in such other guarantee program acceptable to the Trustee.)

  

 

 

SCHEDULE A

SCHEDULE OF EXCHANGES OF INTERESTS IN THE GLOBAL
SECURITY

The
following exchanges of a part of this Global Security for an interest in
another Global Security or for Securities in certificated form, have been made:

	
  Date of Exchange

  	
   

  	
  Amount of decrease

  in Principal amount

  of this Global

  Security

  	
   

  	
  Amount of Increase

  in Principal amount

  of this Global

  Security

  	
   

  	
  Principal amount of

  this Global

  Security following

  such decrease

  or increase

  	
   

  	
  Signature or

  authorized signatory

  of Trustee or Note

  CustodianExhibit
4.5

MEDIMMUNE,
INC.

Certificate No. B-1

THIS SECURITY IS A GLOBAL
SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS
REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE OF A DEPOSITARY OR A
SUCCESSOR DEPOSITARY.  THIS SECURITY IS
NOT EXCHANGEABLE FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN
THE DEPOSITARY OR ITS NOMINEE EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN
THE INDENTURE, AND NO TRANSFER OF THIS SECURITY (OTHER THAN A TRANSFER OF THIS
SECURITY AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A
NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE
DEPOSITARY) MAY BE REGISTERED EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN
THE INDENTURE.

UNLESS THIS CERTIFICATE
IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A
NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF
TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE
NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH
OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY
TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON
IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN
INTEREST HEREIN.

TRANSFERS OF THIS GLOBAL
SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES
OF CEDE & CO. OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND
TRANSFERS OF PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS
MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN SECTION 2.16 OF THE
INDENTURE.

 

1.625%
Convertible Senior Note due 2013

Certificate No. B-1

CUSIP No.
584699 AJ1

MedImmune, Inc., a
Delaware corporation (the “Company”), for
value received, hereby promises to pay to Cede & Co., or its registered
assigns, the principal sum of five hundred million dollars ($500,000,000) on
July 15, 2013 and to pay interest thereon, as provided on the reverse hereof,
until the principal and any unpaid and accrued interest are paid or duly
provided for.

Interest Payment Dates:
January 15 and July 15, with the first payment to be made on January 15, 2007.

Record Dates: January 1
and July 1.

The provisions on the
back of this certificate are incorporated as if set forth on the face hereof.

 

IN WITNESS WHEREOF,
MedImmune, Inc. has caused this instrument to be duly signed.

	
  

  	
   

  	
  MEDIMMUNE, INC.

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:

  	
   

  
	
   

  	
   

  	
   

  	
  Name:

  	
   

  
	
   

  	
   

  	
   

  	
  Title:

  	
   

  

 

Dated: September __, 2006

 

 

	
  TRUSTEE’S CERTIFICATE OF AUTHENTICATION

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  This is one of the Securities referred to

  	
   

  	
   

  
	
  in the within-mentioned Indenture.

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  THE BANK OF NEW YORK,
  as Trustee

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  By:

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Authorized
  Signatory

  	
   

  	
   

  

 

Dated: September
__, 2006

 

 

[REVERSE OF SECURITY]

MEDIMMUNE, INC.

1.625% Convertible Senior Note due 2013

1.             Interest.  MedImmune, Inc., a Delaware corporation (the “Company”), promises to pay interest on the principal amount
of this Security at the rate per annum shown
above.  The Company will pay interest,
payable semi-annually in arrears, on January 15 and July 15 of each year, with
the first payment to be made on January 15, 2007.  Interest on the Securities will accrue on the
principal amount from, and including, the most recent date to which interest
has been paid or provided for or, if no interest has been paid, from, and
including, June 28, 2006, in each case to, but excluding, the next interest
payment date or Maturity Date, as the case may be.  Interest will be computed on the basis of a
360-day year of twelve 30-day months.

2.             Maturity.  The Securities will mature on July 15, 2013.

3.             Method of
Payment.  Except as provided
in the Indenture (as defined below), the Company will pay interest on the
Securities to the persons who are Holders of record of Securities at the close
of business on the record date set forth on the face of this Security next
preceding the applicable interest payment date. 
Holders must surrender Securities to a Paying Agent to collect the
principal amount or Fundamental Change Repurchase Price of the Securities,
plus, if applicable, accrued and unpaid interest, if any, payable as herein
provided on the Maturity Date or upon Repurchase Upon Fundamental Change, as
the case may be.  The Company will pay,
in money of the United States that at the time of payment is legal tender for
payment of public and private debts, all amounts due in cash with respect to
the Securities, which amounts shall be paid (A) in the case this Security is in
global form, by wire transfer of immediately available funds to the account
designated by the Depositary or its nominee; (B) in the case this Security is
held, other than global form, by a Holder of more than five million dollars
($5,000,000) in aggregate principal amount of Securities, by wire transfer of
immediately available funds to the account specified by such Holder or, if such
Holder does not specify an account, by mailing a check to the address of such
Holder set forth in the register of the Registrar; and (C) in the case this
Security is held, other than global form, by a Holder of five million dollars
($5,000,000) or less in aggregate principal amount of Securities, by mailing a
check to the address of such Holder set forth in the register of the Registrar.

4.             Paying Agent,
Registrar, Conversion Agent. 
Initially, The Bank of New York (the “Trustee”)
will act as Paying Agent, Registrar, Bid Solicitation Agent and Conversion
Agent.  The Company may change any Paying
Agent, Registrar, Bid Solicitation Agent or Conversion Agent without prior
notice.

5.             Indenture.  The Company issued the Securities under an
Indenture dated as of June 28, 2006 (the “Indenture”)
between the Company and the Trustee.  The
terms of the Securities include those stated in the Indenture and those made part
of the Indenture by reference to the Trust Indenture Act of 1939 (15 U.S. Code
§§ 77aaa-77bbbb) (the “TIA”) as
amended and in effect from time to time. 
The Securities are subject to all such terms, and Holders are referred
to the Indenture and the TIA for a statement of such terms.  The Securities are general unsecured 

 1
 

 

senior obligations of the Company limited to
$500,000,000 aggregate principal amount ($575,000,000 if the Initial Purchasers
have elected to exercise in full the Option to purchase up to an additional
$75,000,000 aggregate principal amount of the Securities), except as otherwise
provided in the Indenture (except for Securities issued in substitution for
destroyed, mutilated, lost or stolen Securities).  Terms used herein without definition and
which are defined in the Indenture have the meanings assigned to them in the
Indenture.

6.             No Optional
Redemption.

Prior to maturity, the
Securities shall not be subject to redemption at the option of the Company.

7.             Repurchase
at Option of Holder Upon a Fundamental Change.  Subject to the terms and conditions of the
Indenture, in the event of a Fundamental Change, each Holder of the Securities
shall have the right, at the Holder’s option, to require the Company to
repurchase such Holder’s Securities including any portion thereof which is
$1,000 in principal amount or any integral multiple thereof on a date selected
by the Company (the “Fundamental Change
Repurchase Date”), which date is no later than thirty five (35)
days, nor earlier than twenty (20) days, after the date on which notice of such
Fundamental Change is mailed in accordance with the Indenture, at a price
payable in cash equal to one hundred percent (100%) of the principal amount of
such Security, plus accrued and unpaid interest to, but excluding, the
Fundamental Change Repurchase Date; provided, however, that if such Fundamental Change Repurchase Date is
after a record date for the payment of an installment of interest and on or
before the related interest payment date, then the accrued and unpaid interest,
if any, to, but excluding, such interest payment date will be paid on such
interest payment date to the Holder of record of such Securities at the close
of business on such record date, and the Holder surrendering such Securities for
repurchase will not be entitled to any such accrued and unpaid interest unless
such Holder was also the Holder of record of such Securities at the close of
business on such record date.

8.             Conversion.

The Securities
shall be convertible into cash, and if applicable, shares of Common Stock if
and to the extent the conditions therefor specified the Indenture are
satisfied.

To convert a
Security, a Holder must (1) complete and sign the Conversion Notice, with
appropriate signature guarantee, on the back of the Security, (2) surrender the
Security to a Conversion Agent, (3) furnish appropriate endorsements and
transfer documents if required by the Registrar or Conversion Agent, (4) pay
the amount of interest, if any, the Holder must pay in accordance with the Indenture
and (5) pay any tax or duty if required pursuant to the Indenture.  A Holder may convert a portion of a Security
if the portion is $1,000 principal amount or an integral multiple of $1,000
principal amount.

Notwithstanding anything herein to the contrary, no
Security may be converted after the close of business on the Business Day
immediately preceding the Maturity Date.

 2
 

 

Upon conversion of a
Security, the Holder thereof shall be entitled to receive the cash and, if
applicable, shares of Common Stock payable upon conversion in accordance with Article X of the Indenture.

The initial Conversion
Rate is 29.9679 shares of Common Stock per $1,000 principal amount of
Securities (which results in an effective initial Conversion Price of
approximately $33.37 per share) subject to adjustment in the event of certain
circumstances as specified in the Indenture. 
The Company will deliver cash in lieu of any fractional share.

The Conversion Rate
applicable to each Security that is surrendered for conversion, in accordance
with the Securities and Article X of
the Indenture, at any time during the Make-Whole Conversion Period with respect
to a Make-Whole Fundamental Change shall be increased to an amount equal to the Conversion Rate that would,
but for Section 10.14 of the Indenture, otherwise apply to
such Security pursuant to Article X of
the Indenture, plus an amount
equal to the Make-Whole Applicable Increase; provided, however,
that such increase to the Conversion Rate shall not apply if such Make-Whole
Fundamental Change is announced by the Company but shall not be consummated.

9.             Denominations,
Transfer, Exchange.  The
Securities are in registered form, without coupons, in denominations of $1,000
principal amount and integral multiples of $1,000 principal amount.  The transfer of Securities may be registered
and Securities may be exchanged as provided in the Indenture.  The Registrar may require a Holder, among
other things, to furnish appropriate endorsements and transfer documents.  No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a
sum sufficient to cover any tax or similar governmental charge that may be
imposed in connection with certain transfers or exchanges.  The Company or the Trustee, as the case may
be, shall not be required to register the transfer of or exchange any Security
for which a Purchase Notice has been delivered, and not withdrawn, in
accordance with the Indenture, except the unrepurchased portion of Securities
being repurchased in part.

10.           Persons Deemed Owners.  The registered Holder of a Security may be
treated as the owner of such Security for all purposes.

11.           Merger or Consolidation.  The Company shall not consolidate with, or
merge with or into, or sell, transfer, lease, convey or otherwise dispose of
all or substantially all of the property or assets of the Company to, another
person, whether in a single transaction or series of related transactions,
unless (i) such other person is a corporation, limited liability company,
partnership, trust or other entity organized and existing under the laws of the
United States, any State thereof, the District of Columbia or any foreign
country; (ii) such person assumes by supplemental indenture all the obligations
of the Company under the Securities and the Indenture; and (iii) immediately
after giving effect to the transaction, no Default or Event of Default shall
exist.

12.           Amendments, Supplements
and Waivers.  Subject to
certain exceptions, the Indenture or the Securities may be amended or
supplemented with the consent of the Holders of at least a majority in
aggregate principal amount of the outstanding Securities, and certain existing
Defaults or Events of Default may be waived with the consent of the Holders of
a 

 3
 

 

majority in aggregate principal amount of the
Securities then outstanding.  In
accordance with the terms of the Indenture, the Company, with the consent of
the Trustee, may amend or supplement this Indenture or the Securities without
notice to or the consent of any Securityholder: (i) to comply with Sections  5.01 and 10.11 of the Indenture; (ii) to make any changes or
modifications to the Indenture necessary in connection with the registration of
the Securities under the Securities Act pursuant to the Registration Rights
Agreement or the qualification of the Indenture under the TIA; (iii) to secure
the obligations of the Company in respect of the Securities; (iv) to add to the
covenants of the Company described in the Indenture for the benefit of
Securityholders or to surrender any right or power conferred upon the Company;
and (v) to make provisions with respect to adjustments to the Conversion Rate
as required by the Indenture or to increase the Conversion Rate in accordance
with the Indenture.  In addition, the Company
and the Trustee may enter into a supplemental indenture without the consent of
Holders of the Securities to (i) cure any ambiguity, defect, omission or
inconsistency in the Indenture in a manner that does not, individually or in
the aggregate with all other changes, adversely affect the rights of any Holder
in any material respect or (ii) conform the Indenture or the Securities to the
description thereof contained in the Offering Memorandum under the caption “Description
of notes.”

13.           Defaults and Remedies.

If an Event of Default
(excluding an Event of Default specified in Section
6.01(viii) or (ix)
of the Indenture with respect to the Company (but including an Event of Default
specified in Section 6.01(viii) or (ix) of the Indenture solely with respect to a Significant
Subsidiary of the Company or any group of Subsidiaries that in the aggregate
would constitute a Significant Subsidiary of the Company)) occurs and is
continuing, the Trustee by notice to the Company or the Holders of at least
twenty five percent (25%) in principal amount of the Securities then outstanding
by notice to the Company and the Trustee may declare the Securities to be due
and payable.  Upon such declaration, the
principal of, and any premium and accrued and unpaid interest (including any
additional interest) on, all Securities shall be due and payable
immediately.  If an Event of Default
specified in Section  6.01(viii) or (ix) of the Indenture with respect to the Company
(excluding, for purposes of this sentence, an Event of Default specified in Section  6.01(viii) or (ix) of the Indenture solely with respect to a Significant
Subsidiary of the Company or any group of Subsidiaries that in the aggregate
would constitute a Significant Subsidiary of the Company) occurs, the principal
of, and premium and accrued and unpaid interest (including any additional
interest) on, all the Securities shall ipso facto become
and be immediately due and payable without any declaration or other act on the
part of the Trustee or any Holder.  The
Holders of a majority in aggregate principal amount of the Securities then
outstanding by written notice to the Trustee may rescind or annul an
acceleration and its consequences if (A) the rescission would not conflict with
any order or decree, (B) all existing Events of Default, except the nonpayment
of principal, premium or interest (including additional interest) that has
become due solely because of the acceleration, have been cured or waived and
(C) all amounts due to the Trustee under Section 7.07 of
the Indenture have been paid.

Holders may not enforce
the Indenture or the Securities except as provided in the Indenture.  The Holders of a majority in aggregate
principal amount of the Securities then outstanding may direct the time, method
and place of conducting any proceeding for any remedy available to the Trustee
or exercising any trust or power conferred on it.  However, the Trustee 

 4
 

 

may refuse to follow any direction that conflicts with
law or the Indenture, is unduly prejudicial to the rights of other Holders or
would involve the Trustee in personal liability unless the Trustee is offered
indemnity reasonably satisfactory to it; provided, that
the Trustee may take any other action deemed proper by the Trustee which is not
inconsistent with such direction.

If a Default or Event of
Default occurs and is continuing as to which the Trustee has received written
notice pursuant to the provisions of the Indenture, or as to which a
Responsible Officer of the Trustee shall have actual knowledge, the Trustee
shall mail to each Holder a notice of the Default or Event of Default within
thirty (30) days after it occurs unless such Default or Event of Default has
been cured or waived.  Except in the case
of a Default or Event of Default in payment of any amounts due with respect to
any Security, the Trustee may withhold the notice if, and so long as it in good
faith determines that, withholding the notice is in the best interests of
Holders.  The Company must deliver to the
Trustee an annual compliance certificate.

14.           Registration Rights.  The Holders are entitled to registration
rights as set forth in the Registration Rights Agreement.  The Holders shall be entitled to receive
additional interest in certain circumstances, all as set forth in the
Registration Rights Agreement.

15.           Trustee Dealings with the
Company.  The Trustee under
the Indenture, or any banking institution serving as successor Trustee
thereunder, in its individual or any other capacity, may make loans to, accept
deposits from, and perform services for, the Company or its Affiliates, and may
otherwise deal with the Company or its Affiliates, as if it were not Trustee.

16.           No Recourse Against Others.  No past, present or future director, officer,
employee or stockholder, as such, of the Company shall have any liability for
any obligations of the Company under the Securities or the Indenture or for any
claim based on, in respect of, or by reason of, such obligations or their
creation.  Each Holder, by accepting a
Security, waives and releases all such liability.  The waiver and release are part of the
consideration for the issue of the Securities.

17.           Authentication.  This Security shall not be valid until
authenticated by the manual signature of the Trustee or an authenticating agent
in accordance with the Indenture.

18.           Abbreviations.  Customary abbreviations may be used in the
name of a Holder or an assignee, such as: TEN COM (= tenants in common), TEN
ENT (= tenants by the entirety), JT TEN (= joint tenants with right of
survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A
(Uniform Gifts to Minors Act).

THE COMPANY WILL FURNISH
TO ANY HOLDER UPON WRITTEN REQUEST AND WITHOUT CHARGE A COPY OF THE
INDENTURE.  REQUESTS MAY BE MADE TO:

MedImmune, Inc.

One MedImmune Way

Gaithersburg, MD 20878

Attn: General Counsel

 5

 

[FORM OF
ASSIGNMENT]

	
  

  	
   

  	
   

  
	
  I or we assign to

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING
  NUMBER

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  (please print or type name and address)

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  the within Security and all rights thereunder, and
  hereby irrevocably constitute and appoint

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  
	
  Attorney to transfer the Security on the books of
  the Company with full power of substitution in the premises.

  

 

	
  Dated:

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  NOTICE: The signature on this assignment must
  correspond with the name as it appears upon the face of the within Security
  in every particular without alteration or enlargement or any change
  whatsoever and be guaranteed by a guarantor institution participating in the
  Securities Transfer Agents Medallion Program or in such other guarantee
  program acceptable to the Registrar.

  

 

	
  Signature Guarantee:

  	
   

  	
   

  

 

 

In connection with any
transfer of this Security occurring prior to the date which is the earlier of
(i) the date of the declaration by the SEC of the effectiveness of a
registration statement under the Securities Act of 1933, as amended, covering
resales of this Security (which effectiveness shall not have been suspended or
terminated at the date of the transfer) and (ii) the Resale Restriction
Termination Date, the undersigned confirms that it is making, and it has not
utilized any general solicitation or general advertising in connection with,
the transfer:

[Check One]

	
  (1)

  	
   

  	
  ____

  	
   

  	
  to the Company or any Subsidiary thereof, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (2)

  	
   

  	
  ____

  	
   

  	
  pursuant to, and in compliance with, the exemption
  from registration provided by Rule 144A under the Securities Act of 1933, as
  amended, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (3)

  	
   

  	
  ____

  	
   

  	
  pursuant to, and in compliance with, the exemption
  from registration provided by Rule 144 under the Securities Act of 1933, as
  amended, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (4)

  	
   

  	
  ____

  	
   

  	
  pursuant to, and in compliance with, an exemption
  from registration under the Securities Act of 1933, as amended, other than
  Rule 144A or Rule 144, or

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
  (5)

  	
   

  	
  ____

  	
   

  	
  pursuant to an effective registration statement
  under the Securities Act of 1933, as amended.

  

 

Unless one of the
items (1) through (5) is checked, the Registrar will refuse to register any of
the Securities evidenced by this certificate in the name of any person other
than the registered Holder thereof; provided, however, that if item (3) or (4) is checked, the Company or
the Registrar may require, prior to registering any such transfer of the
Securities, in their sole discretion, such written legal opinions,
certifications and other information as the Registrar or the Company have
reasonably requested to confirm that such transfer is being made pursuant to an
exemption from, or in a transaction not subject to, the registration
requirements of the Securities Act of 1933, as amended.  If item (2) is checked, the purchaser must
complete the certification below.

If none of the
foregoing items are checked, the Trustee or Registrar shall not be obligated to
register this Security in the name of any person other than the Holder hereof
unless and until the conditions to any such transfer of registration set forth
herein and in the Indenture shall have been satisfied.

	
  Dated:

  	
   

  	
   

  	
   

  	
  Signed:

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  (Sign exactly as name appears on the other side of
  this Security)

  

 

	
  Signature Guarantee:

  	
   

  	
   

  

 

 

TO BE COMPLETED BY PURCHASER IF (2) ABOVE IS CHECKED

The undersigned represents and warrants that it is
purchasing this Security for its own account or an account with respect to
which it exercises sole investment discretion and that it and any such account
is a “qualified institutional buyer” within the meaning of Rule 144A under the
Securities Act of 1933, as amended, and is aware that the sale to it is being
made in reliance on Rule 144A and acknowledges that it has received such
information regarding the Company as the undersigned has requested pursuant to
Rule 144A and acknowledges that the transferor is relying upon the undersigned’s
foregoing representations in order to claim the exemption from registration
provided by Rule 144A.

	
  Dated:

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
  NOTICE:

  	
   

  	
  To be executed by an executive officer

  

 

 

CONVERSION NOTICE

To convert this Security in accordance with the
Indenture, check the box:   o

To convert only part of this Security, state the
principal amount to be converted (must be in multiples of $1,000):

$                                 

If you want the stock
certificate representing the shares of Common Stock, if any, issuable upon
conversion made out in another person’s name, fill in the form below:

	
  

  
	
  (Insert other person’s soc.
  sec. or tax I.D. no.)

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
   

  
	
  (Print or type
  other person’s name, address and zip code)

  
	
   

  
	
   

  

 

	
  Date:

  	
   

  	
   

  	
   

  	
  Signature(s):

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  (Sign exactly as your name(s) appear(s) on the other
  side of this Security)

  

 

 

	
  Signature(s) guaranteed by:

  	
   

  	
   

  
	
   

  	
   

  	
  (All signatures must be guaranteed by a guarantor
  institution participating in the Securities Transfer Agents Medallion Program
  or in such other guarantee program acceptable to the Trustee.)

  

 

 

PURCHASE NOTICE

Certificate No. of Security:  ___________

If you want to elect to
have this Security purchased by the Company pursuant to Section
3.02 of the Indenture, check the box:

If you want to elect to
have only part of this Security purchased by the Company pursuant to Section 3.02 of the Indenture, state the principal amount to
be so purchased by the Company:

$                                                                 

(in an integral multiple of $1,000)

	
  Date:

  	
   

  	
   

  	
   

  	
  Signature(s):

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
  (Sign exactly as your name(s) appear(s) on the other
  side of this Security)

  

 

	
  Signature(s) guaranteed by:

  	
   

  	
   

  
	
   

  	
   

  	
  (All signatures must be guaranteed by a guarantor
  institution participating in the Securities Transfer Agents Medallion Program
  or in such other guarantee program acceptable to the Trustee.)

  

 

 

SCHEDULE A

SCHEDULE OF EXCHANGES OF INTERESTS IN THE GLOBAL
SECURITY

The
following exchanges of a part of this Global Security for an interest in
another Global Security or for Securities in certificated form, have been made:

	
  Date of Exchange

  	
   

  	
  Amount of decrease

  in Principal amount

  of this Global

  Security

  	
   

  	
  Amount of Increase

  in Principal amount

  of this Global

  Security

  	
   

  	
  Principal amount of

  this Global

  Security following

  such decrease

  or increase

  	
   

  	
  Signature or

  authorized signatory

  of Trustee or Note

  Custodian

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00110-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00110-of-00352.parquet"}]]