Document:

exv10w28

 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Exhibit 10.28

EXECUTION COPY

 

AMENDED AND RESTATED

RESEARCH AND DEVELOPMENT AGREEMENT

among

DYNAVAX TECHNOLOGIES CORPORATION,

SYMPHONY DYNAMO HOLDINGS LLC,

and

SYMPHONY DYNAMO, INC.

 

Dated as of April 18, 2006

 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

 

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Page	 
	1.	 	Assignment	 	 	1	 
	 
	 	 	 	 	 	 	 	 
	2.	 	Overview of Development	 	 	1	 
	 
	 	 	 	 	 	 	 	 
	3.	 	Development Committee	 	 	2	 
	 
	 	 	 	 	 	 	 	 
	4.	 	Development Plan and Development Budget	 	 	2	 
	 
	 	 	 	 	 	 	 	 
	 
	 	4.1	 	Generally	 	 	2	 
	 
	 	4.2	 	Amendments	 	 	3	 
	 
	 	4.3	 	Dynavax Funded Research	 	 	4	 
	 
	 	 	 	 	 	 	 	 
	5.	 	Regulatory Matters	 	 	4	 
	 
	 	 	 	 	 	 	 	 
	 
	 	5.1	 	FDA Sponsor	 	 	4	 
	 
	 	5.2	 	Correspondence	 	 	5	 
	 
	 	5.3	 	Inspections	 	 	5	 
	 
	 	5.4	 	Transfer of FDA Sponsorship	 	 	5	 
	 
	 	 	 	 	 	 	 	 
	6.	 	Dynavax’s Obligations	 	 	6	 
	 
	 	 	 	 	 	 	 	 
	 
	 	6.1	 	Generally	 	 	6	 
	 
	 	6.2	 	Subcontracting	 	 	7	 
	 
	 	6.3	 	Reports	 	 	7	 
	 
	 	6.4	 	Staffing	 	 	7	 
	 
	 	6.5	 	QA Audit	 	 	7	 
	 
	 	6.6	 	Financial Audit	 	 	8	 
	 
	 	6.7	 	Insurance	 	 	8	 
	 
	 	 	 	 	 	 	 	 
	7.	 	Symphony Dynamo’s Obligations	 	 	8	 
	 
	 	 	 	 	 	 	 	 
	 
	 	7.1	 	Generally	 	 	8	 
	 
	 	7.2	 	Subcontracting	 	 	8	 
	 
	 	7.3	 	Insurance	 	 	9	 
	 
	 	7.4	 	Staffing	 	 	9	 
	 
	 	7.5	 	Audit	 	 	9	 
	 
	 	 	 	 	 	 	 	 
	8.	 	Funding and Payments	 	 	9	 
	 
	 	 	 	 	 	 	 	 
	 
	 	8.1	 	Use of Proceeds	 	 	9	 
	 
	 	8.2	 	Reimbursement	 	 	10	 
	 
	 	8.3	 	Budget Allocation and Deviations	 	 	10	 
	 
	 	8.4	 	Employee Benefits	 	 	10	 
	 
	 	 	 	 	 	 	 	 
	9.	 	Covenants	 	 	10	 
	 
	 	 	 	 	 	 	 	 
	 
	 	9.1	 	Mutual Covenants	 	 	10	 
	 
	 	 	 	 	 	 	 	 
	10.	 	Confidentiality	 	 	11	 
	 
	 	 	 	 	 	 	 	 
	 
	 	10.1	 	Confidentiality Agreement	 	 	11	 
	 
	 	10.2	 	Permitted Disclosure of Information	 	 	12	 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

i

 

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Page	 
	 
	 	 	 	 	 	 	 	 
	11.	 	Options and Licensing	 	 	12	 
	 
	 	 	 	 	 	 	 	 
	 
	 	11.1	 	Program Option	 	 	12	 
	 
	 	11.2	 	Symphony Dynamo’s Hepatitis B Program Option	 	 	13	 
	 
	 	11.3	 	Discontinuation Option	 	 	13	 
	 
	 	11.4	 	Related Oncology Product Licensing	 	 	15	 
	 
	 	 	 	 	 	 	 	 
	12.	 	Representations and Warranties	 	 	15	 
	 
	 	 	 	 	 	 	 	 
	 
	 	12.1	 	Dynavax Representations and Warranties	 	 	15	 
	 
	 	12.2	 	Symphony Dynamo Representations and Warranties	 	 	16	 
	 
	 	 	 	 	 	 	 	 
	13.	 	Relationship Between Dynavax and Symphony Dynamo	 	 	18	 
	 
	 	 	 	 	 	 	 	 
	14.	 	Change of Control	 	 	18	 
	 
	 	 	 	 	 	 	 	 
	15.	 	No Restrictions; Indemnification	 	 	18	 
	 
	 	 	 	 	 	 	 	 
	 
	 	15.1	 	No Restrictions	 	 	18	 
	 
	 	15.2	 	Indemnification	 	 	18	 
	 
	 	 	 	 	 	 	 	 
	16.	 	LIMITATION OF LIABILITIES	 	 	22	 
	 
	 	 	 	 	 	 	 	 
	 
	 	16.1	 	Between the Parties	 	 	22	 
	 
	 	16.2	 	Pursuant to the RRD Services Agreement	 	 	22	 
	 
	 	 	 	 	 	 	 	 
	17.	 	Term and Termination	 	 	22	 
	 
	 	 	 	 	 	 	 	 
	 
	 	17.1	 	Term	 	 	22	 
	 
	 	17.2	 	Termination for Dynavax’s Breach	 	 	22	 
	 
	 	17.3	 	Termination for Symphony Dynamo’s Breach	 	 	23	 
	 
	 	17.4	 	Termination of License Agreement	 	 	23	 
	 
	 	17.5	 	Survival	 	 	23	 
	 
	 	 	 	 	 	 	 	 
	18.	 	Miscellaneous	 	 	23	 
	 
	 	 	 	 	 	 	 	 
	 
	 	18.1	 	No Petition	 	 	23	 
	 
	 	18.2	 	Notices	 	 	24	 
	 
	 	18.3	 	Governing Law; Consent to Jurisdiction and Service of Process	 	 	25	 
	 
	 	18.4	 	WAIVER OF JURY TRIAL	 	 	25	 
	 
	 	18.5	 	Entire Agreement	 	 	25	 
	 
	 	18.6	 	Amendment; Successors; Assignment; Counterparts	 	 	26	 
	 
	 	18.7	 	Severability	 	 	26	 
	 
	 	18.8	 	Third Party Beneficiary	 	 	26	 

	 	 	 	 	 
	Schedule 12.1(f)   –   Material Contracts
	 
	 	 	 	 
	Annex A

	 	–
	 	Certain Definitions
	Annex B

	 	–
	 	Development Committee Charter
	Annex C

	 	–
	 	Initial Development Plan
	Annex D

	 	–
	 	Initial Development Budget
	Annex E

	 	–
	 	Payment Terms

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

ii

 

AMENDED AND RESTATED

RESEARCH AND DEVELOPMENT AGREEMENT

          This AMENDED AND RESTATED RESEARCH AND DEVELOPMENT AGREEMENT (this “Agreement”) is entered
into as of April 18, 2006 (the “Closing Date”), by and among DYNAVAX TECHNOLOGIES CORPORATION, a
Delaware corporation (“Dynavax”), SYMPHONY DYNAMO, INC., a Delaware corporation (“Symphony Dynamo”)
(each of Dynavax and Symphony Dynamo being a “Party,” and collectively, the “Parties”), and
SYMPHONY DYNAMO HOLDINGS LLC, a Delaware limited liability company (“Holdings”) (which shall be a
Party to this Agreement solely with respect to Articles 1, 11 and 14, and
Sections 5.2, 5.3, 6.3, 6.4, 6.7 and 7.5).
Capitalized terms used herein and not defined herein shall have the meanings assigned to such terms
in Annex A attached hereto.

PRELIMINARY STATEMENT

          Dynavax and Holdings have entered into that certain Research and Development Agreement, dated
as of April 18, 2006 (the “Research and Development Agreement”). Pursuant to this Agreement,
Holdings desires to assign all of its rights and delegate its obligations under the Research and
Development Agreement to Symphony Dynamo, and Dynavax and Symphony Dynamo desire to amend and
restate the terms and conditions of the Research and Development Agreement.

          In the Novated and Restated Technology License Agreement, Dynavax grants Symphony Dynamo an
exclusive license to develop and commercialize certain Products. Symphony Dynamo wishes for
Dynavax to continue to develop such Products. Symphony Dynamo and Dynavax desire to establish, and
agree on the responsibilities of, a Development Committee to oversee such development. Dynavax and
Symphony Dynamo further desire to comply with and perform certain agreements and obligations
related thereto.

          The Parties hereto agree as follows:

	1.	 	Assignment. The Parties agree that from and after the Closing Date, all of the rights and
obligations of Holdings under the Research and Development Agreement will be assigned and
transferred to, and assumed by, Symphony Dynamo.
	 
	2.	 	Overview of Development. The Parties shall develop the Programs in a collaborative and
efficient manner, as set forth below.

     (a) Representatives of the Parties shall engage in joint decision-making for the
Programs as set forth in Articles 3 and 4. Symphony Dynamo shall have
overall responsibility for all matters set forth in the Development Plan (pursuant to
Article 7 hereof), and shall engage Dynavax (pursuant to Article 6 hereof),
RRD International,
LLC (“RRD”) (pursuant to the RRD Services Agreement), and such independent contractors and
agents as RRD and Dynavax may retain on Symphony Dynamo’s behalf (which contractors may
include entities retained by Dynavax prior to the Closing Date), to act on behalf of
Symphony Dynamo and carry out the duties set forth therein and

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

 

 

herein, including, without
limitation, management and accounting functions, pre-clinical and clinical development,
scientific and technical services associated with such development, and patent work under
the Programs.

     (b) Dynavax hereby acknowledges and agrees to Symphony Dynamo’s engagement of RRD to
act on behalf of Symphony Dynamo and to carry out the duties set forth herein and in the RRD
Services Agreement. In accordance with this Agreement, the Parties each hereby agree that
Dynavax shall have primary responsibility for implementation of the Programs;
provided, however, that any implementation responsibility which may be
delegated to RRD following the Closing Date shall be executed subject to the oversight of
the Symphony Dynamo Board and the Development Committee. Notwithstanding the foregoing,
nothing in this Section 2(b) shall limit the rights and responsibilities of the
Development Committee as set forth in the Symphony Dynamo Charter and the Development
Committee Charter.

     (c) With respect to the Hepatitis B Program, the Hepatitis C Program and the Cancer
Program, Dynavax shall be responsible for the execution of all pre-clinical and clinical
development, all scientific and technical services associated with such development, and all
patent work, including all related matters set forth in the Development Plan for such
Programs.

     (d) Nothing in clause (c) shall in any way limit the authority of the
Development Committee (as defined below) or the Symphony Dynamo Board hereunder, and the
engagements and delegations set forth therein shall be subject to the terms and conditions
of this Agreement and the RRD Services Agreement, and the satisfactory performance by RRD
and Dynavax of their obligations pursuant hereto and thereto. The allocations of
responsibility described in this Article 2 shall remain subject to further
modification in accordance with the terms and conditions of this Agreement and the RRD
Services Agreement.

	3.	 	Development Committee. The Parties shall establish and maintain a committee (the
“Development Committee”) to oversee the development of the Programs (including the continued
development and refinement of the Development Plan and the Development Budget). The
Development Committee shall be established, operated and governed in accordance with the
policies and procedures set forth in Annex B hereto (the “Development Committee
Charter”). The Development Committee Charter may be amended only with the unanimous approval
of the Development Committee Members and the consent of the Symphony Dynamo Board. In no
event shall the Development Committee have the power to amend the terms of any Operative
Document.
	 
	4.	 	Development Plan and Development Budget.

     4.1 Generally. The Parties have agreed, as of the Closing Date, to an Initial Development
Plan and an Initial Development Budget, which are attached hereto and incorporated herein as
Annex C and Annex D, respectively, and which shall be further developed and refined
from time to time in accordance herewith. The Initial Development Plan consists (and the
Development Plan shall consist) of detailed provisions governing all pre-clinical,

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

2

 

clinical,
scientific, technical, regulatory and patent work to be performed under the Operative Documents.
Following the Closing Date, the Development Committee shall, on an ongoing basis, further develop
the Development Plan to include, without limitation, (i) an outline of the plan for the development
of each Program; (ii) detailed Protocols for each Program; and (iii) outlines of non-clinical
activities, key regulatory and quality activities, and CMC activities for each Program. The
Initial Development Budget consists (and the Development Budget shall consist) of two (2)
components: (x) a budget for the Development Plan (the “Clinical Budget Component”), and (y) a
budget for the management and administrative functions of Symphony Dynamo, as set forth in Section
1(a) of the RRD Services Agreement (the “Management Budget Component”). The Clinical Budget
Component shall be further divided into separate budgets for each Program, and, following the
Closing Date, the Development Committee shall further develop and refine the Clinical Budget
Component to include, without limitation, (1) budget spreadsheets summarizing anticipated costs of
engaging third party service providers for each Protocol and the scope of Protocol-related work to
be performed by such third parties; and (2) the number of full-time equivalents (“FTEs”) to be
dedicated to the Programs (by function and work responsibilities, on a Program-by-Program basis).
All presently anticipated or actual expenditures of Symphony Dynamo, [ * ] are included in the
Initial Development Budget attached hereto as Annex D, and will continue to be included in
any amendments thereof. The Development Committee shall, at the request of the Symphony Dynamo
Board, submit the Development Plan and the Development Budget (as each shall have been developed
and refined up to such point) to the Symphony Dynamo Board for its review at the first meeting of
the Symphony Dynamo Board. Following the Symphony Dynamo Board’s review, the Development Committee
shall work diligently to incorporate the comments generated by the Symphony Dynamo Board’s review
and complete the Development Plan and the Development Budget as soon as practicable, and, upon
completion, submit the Development Plan and the Development Budget to the Symphony Dynamo Board for
approval.

  4.2 Amendments.

          (a) All amendments of and, all material deviations from, the Development Plan and Development
Budget (including amendments or deviations made at the request of Dynavax or RRD, in accordance
with Section 8.3 hereof or Section 2(b) of the RRD Services Agreement, respectively) shall
be made in accordance with the procedures described in this Article 4 and in the
Development Committee Charter, including obtaining the approval of the Symphony Dynamo Board, as
may be required by the Development Committee Charter.

          (b) The Development Committee shall review the Development Plan and Development Budget [ * ]
to determine whether any changes are required, and shall comply with all procedures required to
amend the Development Plan or Development Budget to implement such changes. Furthermore, following
the Closing Date, the Development Committee shall, on an ongoing basis, continue to develop the
Development Plan, including, without limitation, as set forth in Section 4.1 and in
response to requests, proposals or reports from Dynavax and RRD to the Development Committee.

          (c) A Program may only be discontinued in the event that either (i) the Parties mutually agree
to discontinue such Program based on (A) a Medical Discontinuation Event, or (B) scientific
evidence (regardless of whether such evidence is generated by a Party or a third

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

3

 

party) that [ * ]
(a “Scientific Discontinuation Event”) that arises in the course of developing such Program; or
(ii) the Symphony Dynamo Board, by (x) [ * ], or (y) [ * ], resolves to discontinue such Program.
The Development Committee shall promptly thereafter amend the Development Plan to reflect such
discontinuation and amend the Development Budget to reallocate to any or all of the remaining
Programs the funds previously allocated to the discontinued Program (with any funds not then
allocated to be held for reallocation by the Development Committee).

          (d) The Development Plan shall never be amended in any manner that would require Dynavax or
Symphony Dynamo (or any Person acting on behalf of Dynavax or Symphony Dynamo (including RRD and
its RRD Personnel)) to perform any assignments or tasks in a manner that would violate any
applicable law or regulation. In the event of a change in any applicable law or regulation, the
Development Committee shall consider amending the Development Plan to enable Dynavax or Symphony
Dynamo (or any Person acting on behalf of Dynavax or Symphony Dynamo (including RRD and its RRD
Personnel)), as the case may be, to comply fully with such law or regulation. If such amendment is
not approved, the affected Party shall be excused from performing any activity specified herein or
in the Development Plan that would violate or result in a violation of any applicable law or
regulation.

     4.3 Dynavax Funded Research. Each of Symphony Dynamo and Dynavax hereby agrees that, until
the end of the Term, Dynavax, using commercially reasonable methods, may expend its own funds to
extend, increase, or otherwise modify, outside the scope of the Development Plan, the trials and
development activities run by Dynavax, subject to the approval of the Development Committee (which
approval shall not be withheld unless the Development Committee determines in good faith such
changes could have a material adverse effect on the development of the relevant Program). Such
additional Dynavax supplied funds shall not be included in the calculations used to determine the
Discontinuation Price (pursuant to Section 11.3 hereof) or the Purchase Price (pursuant to
Section 2(b) of the Purchase Option Agreement). Dynavax agrees that the results of such research
and development shall immediately become part of the Licensed Intellectual Property and shall
thereafter be subject to the terms of the Operative Documents. Dynavax’s rights pursuant to this
Section 4.3 are in addition to, and separate from, its rights pursuant to Section
8.3 hereof.

	5.	 	Regulatory Matters.

     5.1 FDA Sponsor. Notwithstanding any governance provision contained herein or in any
Operative Document, the Parties agree that, until the termination or unexercised expiration of the
Purchase Option, Dynavax, shall be the FDA Sponsor for the Programs (except any Programs which were
the subject of a Discontinuation Option that was not exercised by Dynavax). Dynavax shall have the
responsibility and the authority to act as the sponsor and make those decisions and take all
actions necessary to assure compliance with all regulatory requirements. Dynavax agrees to be
bound by, and perform all obligations set forth in, 21 C.F.R. § 312 related to its role as the FDA
sponsor for the Programs (the “FDA Sponsor”). Notwithstanding anything to the contrary in
Article 4 or the Development Committee Charter, Dynavax, in its capacity as FDA Sponsor,
may discontinue or modify any Program without the approval of the Development Committee or the
Symphony Dynamo Board in the event such actions are (a) triggered by an event that is reportable to
the FDA; and (b) reasonably necessary

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

4

 

to avoid the imposition of criminal or civil liability;
provided, however, that to the extent commercially reasonable, Dynavax shall (i)
pursuant to Section 5.2, advise and consult with the Development Committee prior to taking
such action and (ii) forward a copy of all such correspondence to the members of the Symphony
Dynamo Board.

     5.2 Correspondence. Each Party hereto acknowledges that Dynavax, in its capacity as FDA
Sponsor and acting at the direction of the Development Committee, shall be the Party responding to
any regulatory correspondence or inquiry. Each Party shall (a) notify the other Parties promptly
of any FDA or other governmental or regulatory inspection or inquiry concerning any study or
project under the Programs, including, but not limited to, inspections of investigational sites or
laboratories; and (b) forward to the other Parties copies of any correspondence from any regulatory
or governmental agency relating to such a study or project, including, but not limited to, Form
FD-483 notices and FDA refusal to file, action or warning letters, even if they do not specifically
mention the other Parties. Symphony Dynamo shall obtain the written consent of Dynavax, which
consent will not be unreasonably withheld, before referring to Dynavax or its Affiliates in any
regulatory correspondence, except to the extent that such reference is required by law or simply
refers to the existence of this Agreement or any of the other Operative Documents. Furthermore,
Dynavax shall be the Party responsible for responding to or handling any FDA or regulatory
inspection; provided, that Dynavax shall notify the Development Committee (i) within
twenty-four (24) hours of the commencement of a clinical hold for any Protocol, and (ii)
concurrently with its submission to the FDA of any IND safety reports for the Programs.

     5.3 Inspections. Each Party agrees that during an inspection by the FDA or other Regulatory
Authority concerning any study or project under the Programs, it will not disclose information and
materials that are not required to be disclosed to such agency without the prior consent of
the other Parties, which consent shall not be unreasonably withheld or delayed. Such information
and materials include, but are not limited to, the following: (a) financial data and pricing data
(including, but not limited to, the budget and payment schedule); (b) sales data (other than
shipment data); and (c) personnel data (other than data as to qualification of technical and
professional persons performing functions subject to regulatory requirements).

     5.4 Transfer of FDA Sponsorship.

          (a) On or prior to the thirtieth (30th) day after the unexercised expiration or
termination of the Purchase Option, Dynavax shall cease to act as the FDA sponsor for the Programs
for which Dynavax has not exercised the Program Option or Discontinuation Option, and Dynavax and
Symphony Dynamo shall, at Symphony Dynamo’s expense, take all actions necessary to effect the
transfer of (x) the Regulatory Files solely related to such Programs to Symphony Dynamo or its
designee in accordance with Section 2.7 of the Novated and Restated Technology License
Agreement, and (y) any and all materials necessary for Symphony Dynamo to practice or exploit the
license granted to it under the Novated and Restated Technology License Agreement, by such date.
In conjunction with such transfer, Dynavax hereby assigns to Symphony Dynamo or its designee, as of
the date specified in the first sentence of this Section 5.4(a) all of the material
agreements to which Dynavax is a Party and which: (i) are related to such Programs; and (ii)
provide Dynavax with goods and services (clinical and manufacturing) from third party suppliers and
subcontractors; and (iii) are assignable to Symphony Dynamo or

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

5

 

its designee. Dynavax shall provide
copies of all such contracts to Symphony Dynamo in connection with such transfer. Dynavax shall
use commercially reasonable efforts to cause the transfer of any non-assignable material agreements
meeting the criteria set forth in (i) and (ii) above, or if such agreements are not assignable,
Dynavax shall act as agent of Symphony Dynamo in processing all goods and services under such
agreements. Dynavax agrees to take such commercially reasonable actions as Symphony Dynamo may
request in furtherance of the foregoing, at the expense of Symphony Dynamo. Such efforts shall not
include any obligation for Dynavax to incur any out-of-pocket costs in connection with such
transfer.

          (b) Upon the discontinuation of any of the Programs pursuant to Section 4.2(c),
Dynavax shall have no further obligations with respect to such Programs under the Operative
Documents. If such Programs are transferred or licensed to a third party in accordance with
Section 11.3 (such third party, the “Transferee”), then Dynavax shall cooperate with
Symphony Dynamo and the Transferee to effect the assignment to the Transferee of the sponsorship to
the Regulatory Files with respect to the Program for which Transferee has acquired rights;
provided, however, that Dynavax shall not be obligated to take any action pursuant
to this Section 5.4(b) for which it will not receive full reimbursement from Symphony
Dynamo or another party. The assignment of such Regulatory Files to the Transferee does not
include an assignment of any Licensed Intellectual Property.

	6.	 	Dynavax’s Obligations.

     6.1 Generally.

          (a) Dynavax shall have primary responsibility for the implementation of the Programs, and
shall specifically be responsible for (i) the execution of all matters set forth in the Development
Plan for the Hepatitis B Program, the Hepatitis C Program and the Cancer Program; (ii) except as
otherwise expressly agreed, the manufacture of clinical trial materials for the studies set forth
in the Development Plan and the quality assurance of the Programs; and (iii) the execution of all
other matters set forth in the Development Plan that are delegated to Dynavax by Symphony Dynamo
(collectively, the “Dynavax Obligations”).

          (b) Dynavax agrees that it will work diligently, commit the necessary time and use
commercially reasonable efforts to discharge the Dynavax Obligations in a good scientific manner
and in accordance with the Development Plan, the Development Budget, and the terms of this
Agreement. In the event that Dynavax is unable to execute any of the aforementioned development
activities which comprise the Dynavax Obligations in accordance with the standard established in
the preceding sentence, as determined by the Development Committee, Symphony Dynamo shall discuss
with Dynavax the putative failure, and if the Parties are unable to agree on a remediation plan or
adjustments to the execution concerns within [ * ] days, then Symphony Dynamo shall notify Dynavax
in writing, and shall thereafter have the right to re-assign such development activities in a
manner to be determined by the Development Committee, and Dynavax shall transfer and deliver to
Symphony Dynamo (or RRD on behalf of Symphony Dynamo) any and all materials, documents, files and
other information relating to such development activities; provided, that Dynavax shall be
permitted to retain copies of such transferred materials, documents, files and other information
relating to such development activities as necessary in order to comply with any requirements of a
Governmental Authority.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

6

 

     6.2 Subcontracting. All agreements between Dynavax and third parties (including without
limitation clinical research organizations and contract manufacturers) for such third parties to
perform any Dynavax Obligations (each such third party, a “Dynavax Subcontractor” and each such
agreement, a “Subcontracting Agreement”) entered into by Dynavax prior to the Closing Date shall be
deemed to be acceptable to the Parties in all material respects. Following the Closing Date,
Dynavax shall obtain the approval of the Development Committee prior to entering into any
Subcontracting Agreement or amending or terminating any Subcontracting Agreement. The terms of any
such Subcontracting Agreements shall be deemed the Confidential Information of Dynavax and be
subject to the rights and obligations set forth in the Confidentiality Agreement. Dynavax shall
monitor the performance of its Dynavax Subcontractors and shall promptly notify the Development
Committee with respect to any Dynavax Subcontractor performance issues that may have a material
effect on the Programs. The Development Committee shall have the authority to direct Dynavax to
terminate any Subcontracting Agreement pursuant to the terms thereof.

     6.3 Reports. At each Scheduled Meeting of the Development Committee, Dynavax shall, to the extent
reasonably required by the Development Committee, provide the Development Committee with a summary
of Dynavax’s activities and developments with respect to the Programs for the period following the
most recent preceding Scheduled Meeting. Such summary shall include: (i) a copy of each new
Protocol for the Programs being drafted by Dynavax; (ii) a copy of each standard clinical study
progress report for the Programs received by Dynavax during the preceding month from any of the
clinical research organizations engaged by Dynavax pursuant to any Subcontracting Agreements; (iii)
updates regarding (A) [ * ], and (B) [ * ]; (iv) a financial report itemizing actual spending
under the Development Plan as well as any variation from planned spending; (v) if the portion of
the Development Budget related to a particular Program is altered to the extent that available
funding for such Program no longer appears to be adequate to complete the Program, an updated
budget forecast; and (vi) such other information as the Development Committee may reasonably
request.

     6.4 Staffing. Dynavax shall provide such sufficient and competent staff and Personnel
(including, without limitation, such employees or agents of, or independent contractors retained
by, Dynavax) that have the skill and expertise necessary to perform the Dynavax Obligations.
Dynavax shall notify Symphony Dynamo in advance, if practicable, and in any event promptly
thereafter, of any change in key personnel involved in the Programs.

     6.5 QA Audit. During the Term, Dynavax will permit Symphony Dynamo’s representatives, such
representatives to be identified by Symphony Dynamo in advance and reasonably acceptable to
Dynavax, to examine and audit the work performed by Dynavax hereunder and the Dynavax facilities at
which such work is conducted to determine that the project assignment is being conducted in
accordance with the agreed upon services (“QA Audits”) during regular business hours. Symphony
Dynamo shall give Dynavax reasonable advance notice of such QA Audits specifying the scope of the
audit. Symphony Dynamo shall reimburse Dynavax for its time associated with QA Audits;
provided, however, that should a particular QA Audit reveal a material deficiency
in the work performed, then Symphony Dynamo will not be responsible for costs associated with such
QA Audit, the work to be re-performed or the costs or expenses associated with curing any material
deficiencies. Symphony

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

7

 

Dynamo and Dynavax shall meet to discuss the results of the QA Audit and,
if required, jointly agree upon any actions that will be required as a result of such audits
including defining material deficiencies to be addressed. Dynavax shall make commercially
reasonable efforts to reconcile all such deficiencies found by Symphony Dynamo during such QA
Audit.

     6.6 Financial Audit. During the Term, Dynavax will permit Symphony Dynamo’s representatives,
such representatives to be identified by Symphony Dynamo in advance and reasonably acceptable to
Dynavax, to verify Dynavax’s receipts and FTE records that are related to Dynavax’s performance of
the work under the Programs (“Financial Audits”), which review shall be conducted during regular
business hours and will take place no more than once per year, unless
otherwise agreed to by the Parties. Symphony Dynamo shall give Dynavax reasonable advance
notice of such Financial Audits specifying the scope of the audit, which shall not include work
that has previously undergone Financial Audits. Symphony Dynamo shall reimburse Dynavax for its
time associated with Financial Audits; provided, however, that should a particular
Financial Audit reveal a material discrepancy between such financial records and the reports
submitted by Dynavax to Symphony Dynamo for reimbursement purposes, then Symphony Dynamo will not
be responsible for costs associated with such Financial Audit. Symphony Dynamo and Dynavax shall
meet to discuss the results of the Financial Audit and, if required, jointly agree upon any actions
that will be required as a result of such audits including defining material discrepancies to be
addressed. Dynavax shall make commercially reasonable efforts to reconcile all such discrepancies
found by Symphony Dynamo during such Financial Audit.

     6.7 Insurance. Dynavax shall carry and maintain throughout the Term clinical trial liability
insurance (including errors and omissions coverage and product coverage), at Dynavax’s sole
expense, with limits of at least [ * ], and property insurance covering Products, at Dynavax’s sole
expense, with limits of at least [ * ]. Upon Symphony Dynamo’s request, Dynavax shall instruct its
insurance carrier(s) to promptly furnish to Symphony Dynamo certificates reflecting such coverage
and a representation indicating that such coverage shall not be canceled or otherwise terminated
during the Term without [ * ] days’ prior written notice to Symphony Dynamo. Notwithstanding
anything to the contrary herein, this Section 6.7 shall survive for a period of [ * ]
following termination or expiration of this Agreement.

	7.	 	Symphony Dynamo’s Obligations.

     7.1 Generally. Symphony Dynamo shall have overall managerial and supervisory responsibility
for all matters set forth in the Development Plan, and shall be responsible for (i) executing or
delegating its management and administration responsibilities; and (ii) executing or delegating the
clinical development activities set forth in the Development Plan. Symphony Dynamo shall, and
shall instruct all Persons whom it engages pursuant to Article 2 hereof to, perform its
obligations hereunder and under the Development Plan acting in good faith and in accordance with
the applicable provision of the Development Plan, the Development Budget, and the terms of this
Agreement.

     7.2 Subcontracting. Symphony Dynamo is subcontracting, and will in the future subcontract,
certain of its responsibilities under the Development Plan to RRD (pursuant to the RRD Services
Agreement), to Dynavax (pursuant hereto) and to other vendors and service

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

8

 

providers (pursuant to
subcontracting agreements to be approved by the Development Committee); provided, that
Symphony Dynamo shall remain responsible for the performance of its obligations hereunder
notwithstanding any such arrangement. Any subcontracting agreement entered into by
Symphony Dynamo (other than the RRD Services Agreement, but including such contracts as RRD
may negotiate on its behalf) shall include a provision permitting assignment at any time of the
subcontracting agreement from Symphony Dynamo to Dynavax without the subcontractor’s consent.

     7.3 Insurance. Symphony Dynamo shall maintain insurance with creditworthy insurance companies
against such risks and in such amounts as are usually maintained or insured against by other
companies of established repute engaged in the same or a similar business.

     7.4 Staffing. Symphony Dynamo shall use commercially reasonable efforts to provide, or cause
to be provided on its behalf (including Personnel retained by RRD), sufficient and competent staff
and Personnel that have the skill and expertise necessary to perform Symphony Dynamo’s obligations
under this Agreement, the RRD Services Agreement, the Development Plan and the Development Budget,
including, but not limited to, (i) carrying out its management and administration functions
pursuant to Section 1(a) of the RRD Services Agreement; and (ii) carrying out its clinical
development duties in accordance with Section 1(b) of the RRD Services Agreement, this Agreement,
the Development Plan and the Development Budget. Symphony Dynamo shall notify Dynavax in advance,
if practicable, and in any event promptly thereafter, of any change in key RRD Personnel involved
in the Programs.

     7.5 Audit. Symphony Dynamo shall permit each of Dynavax, Holdings, Investors and each
Symphony Fund and their duly authorized representatives at all reasonable business hours to inspect
(1) Symphony Dynamo’s books, records and other reasonably requested materials, and (2) any and all
properties of Symphony Dynamo, and it shall provide to each of Dynavax, Holdings, Investors and
each Symphony Fund all books, records and other materials related to any meeting of the Symphony
Dynamo Board and to permit Holdings, Investors and each Symphony Fund to make copies or extracts
therefrom; provided, that each aforementioned party may conduct one such inspection in each
calendar year without cost to such party, and that any party conducting additional inspections
shall reimburse the Manager for its reasonable costs and expenses in facilitating such inspection.
Symphony Dynamo and Dynavax shall meet to discuss the results of the audit and, if required,
jointly agree upon any actions that will be required as a result of such audits including defining
material discrepancies to be addressed. Symphony Dynamo shall make commercially reasonable efforts
to reconcile promptly all such discrepancies found by Dynavax, Holdings, Investors or any Symphony
Fund during such audit.

	8.	 	Funding and Payments.

     8.1 Use of Proceeds. Symphony Dynamo shall use any and all net proceeds received by Symphony Dynamo as a result
of the Financing for the development of the Programs and general corporate purposes in support of
the Programs, including the payment of all fees and expenses in accordance with the Development
Plan and the Development Budget, (as may be modified from time to time pursuant to Section
4.2) and the payment of any indemnification obligations of Symphony Dynamo under the Operative
Documents and agreements with third party contractors.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

9

 

     8.2 Reimbursement. Symphony Dynamo shall compensate Dynavax and RRD fully for their
respective Development Plan-associated activities, including without limitation its research,
clinical and manufacturing services, and any other activities delegated to Dynavax or RRD by
Symphony Dynamo or the Development Committee. Such compensation shall be made to (a) Dynavax in
accordance with the provisions of this Article 8 and the payment terms attached hereto as
Annex E (the “Payment Terms”), the terms of which are hereby adopted and incorporated
herein, and (b) RRD in accordance with the payments terms of Section 6 of the RRD Services
Agreement and Annex C thereto.

     8.3 Budget Allocation and Deviations. Dynavax shall have the discretion to incur
out-of-pocket fees, expenses and costs and allocate Dynavax resources in a manner consistent with
the Development Plan and the Development Budget. If Dynavax reasonably anticipates that the actual
cost for any particular activity will exceed the greater of (i) [ * ] of that portion of the
Development Budget allocated for such activity; and (ii) [ * ] of that portion of the Development
Budget allocated for such activity (or such greater amount as the Symphony Dynamo Board may
subsequently determine), then Dynavax may request that the Development Committee amend the
Development Budget, either at its next Scheduled Meeting or at an Ad Hoc Meeting, to reflect such
cost increase. Dynavax shall not be reimbursed for such additional expenditure without the prior
approval of the Development Committee.

     8.4 Employee Benefits. Symphony Dynamo shall not be responsible for providing or paying any
benefits (including, but not limited to, unemployment, disability, insurance, or medical, and any
pension or profit sharing plans) to Dynavax or to any employees of Dynavax or any persons retained
or used by Dynavax to perform activities pursuant to the Development Plan, including independent
contractors, Dynavax Subcontractors and agents of Dynavax (collectively, “Dynavax Personnel”). As
to Dynavax or any Dynavax Personnel, Symphony Dynamo shall not be responsible for: (a) any federal,
state or local income tax withholding; (b) “FICA” contributions; (c) contributions to state
disability funds or liability funds or similar withholdings; (d) payment of any overtime wages; (e)
workers’ compensation; or (f) compliance with any laws, rules or regulations governing employees.
Dynavax agrees that, as between Symphony Dynamo and Dynavax, Dynavax is and will continue to be
solely responsible for: (i) all matters relating to the payment of compensation and provision of
benefits to Dynavax Personnel; and (ii) compliance with all applicable laws, rules and regulations
governing Dynavax’s employees.

	9.	 	Covenants.

     9.1 Mutual Covenants. Each of Dynavax and Symphony Dynamo covenants and agrees that, with
respect to the Programs and any other rights and obligations set forth in the Operative Documents,
it shall:

          (a) perform all of its obligations pursuant to this Agreement in material compliance with: (i)
all applicable federal and state laws, statutes, rules, regulations and orders (including all
applicable approval and qualification requirements thereunder), including, without limitation, the
Federal Food, Drug and Cosmetic Act and the regulations promulgated pursuant thereto; (ii) all
applicable good clinical practices and guidelines; (iii) all applicable standard operating
procedures; (iv) all applicable Protocols; and (v) the provisions of this Agreement;

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

10

 

          (b) keep complete, proper and separate books of record and account, including a record of all
costs and expenses incurred, all charges made, all credits made and received, and all income
derived in connection with the operation of its business, all in accordance with GAAP;

          (c) not employ (or, to the best of its knowledge without further duty of inquiry, shall not
use any contractor or consultant that employs) any individual or entity debarred by the FDA (or
subject to a similar sanction of any other Regulatory Authority), or, to the best of its knowledge
without further duty of inquiry, any individual who or entity which is the subject of an FDA
debarment investigation or proceeding (or similar proceeding of any other Regulatory Authority), in
the conduct of the Programs;

          (d) promptly deliver to the other, upon receipt thereof, notice of all actions, suits,
investigations, litigation and proceedings before any Governmental Authority, which would
reasonably be expected to affect such Party’s ability to perform its obligations under this
Agreement;

          (e) upon it receiving Knowledge of (i) a material event or development with respect to any
Program or (ii) a breach of any covenant or representation of such Party in any material respect,
such Party shall notify the other Party in writing within [ * ] of the receipt of such Knowledge by
any executive officer of such Party, provided that the failure to provide such notice shall not
impair or otherwise be deemed a waiver of any rights any Party may have arising from such material
event or breach. Furthermore, the provision of such notice of material event or development shall
not be deemed an admission by the Party providing such notice of its breach of any of its
covenants, representations or obligations under the Operative Documents; and

          (f) with reasonable promptness, deliver to the other such data and information relating to the
ability of such Person to perform its obligations hereunder as from time to time may be reasonably
requested by the other (subject to the maintenance of the confidentiality of any such information
by the receiving Party). For the avoidance of doubt, this Section 9.1(f) includes Dynavax’s obligations to provide financial and other necessary information to
Symphony Dynamo and RRD to enable Symphony Dynamo to fulfill its obligations to Dynavax under
Section 5(d) of the Purchase Option Agreement, and to enable RRD to fulfill its obligations
to Symphony Dynamo and Dynavax under Sections 5(a) and 5(b) of the RRD Services Agreement.

	10.	 	Confidentiality.

     10.1 Confidentiality Agreement. It is understood that during the course of this Agreement
each of the Parties shall be bound by the terms of the Confidentiality Agreement. In addition, the
Parties’ employees, subcontractors and agents shall be bound by terms substantially similar to the
Confidentiality Agreement. The foregoing shall not be construed to require Dynavax to amend or
supplement any of the agreements it entered into prior to the Closing Date, even if the
confidentiality provisions in such agreements do not satisfy the foregoing requirement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

11

 

     10.2 Permitted Disclosure of Information. The Parties agree that Dynavax shall have access
to, and may use and disclose the Development Plan and any existing or newly generated data or
intellectual property developed with respect to the Programs (i) to obtain the assistance of one or
more third parties to develop and/or commercialize the Programs subject to the terms of this
Agreement, the other Operative Documents and appropriate confidentiality agreements pursuant to
Section 10.1 or as approved by Symphony Dynamo, (ii) to use such intellectual property for
all purposes not licensed exclusively to Symphony Dynamo under the Novated and Restated Technology
License Agreement, and (iii) through press releases, in public presentations or as part of other
appropriate public disclosures; provided that all such disclosure under this Section
10.2 shall be subject to the terms of the Confidentiality Agreement.

	11.	 	Options and Licensing.

     11.1 Program Option

          (a) In consideration for entering into the Operative Documents to which both Dynavax and
Symphony Dynamo are parties, Symphony Dynamo hereby grants Dynavax an exclusive option (the
“Program Option”) to purchase the rights to either the Hepatitis B Program or the Hepatitis C
Program (but not both) at any time during the period beginning on the Closing Date and terminating
on the first (1st) anniversary of the Closing Date (the “Program Option Period”);
provided, however, that Dynavax shall not exercise the Program Option with respect
to the Hepatitis C Program until such time as Dynavax shall have either: (i) [ * ]; or (ii)
[ * ].

          (b) Dynavax may exercise the Program Option by delivery of a written notice (the “Program
Option Exercise Notice”) during the Program Option Period. The Program
Option Exercise Notice shall be delivered on a Business Day to Symphony Dynamo, with a copy to
Holdings, [ * ]. The date on which the Program Option Exercise Notice is first delivered to
Holdings and Symphony Dynamo is referred to as the “Program Option Exercise Date.” The Program
Option Exercise Notice shall specify a closing date for the settlement of the Program Option, which
date shall not be less than [ * ] or more than [ * ] after the Program Option Exercise Date (the
“Program Option Closing Date”).

          (c) If, following an Exercise of the Program Option, the Purchase Option shall expire
unexercised or be terminated, then Dynavax hereby agrees to pay to Holdings, on or before the date
on which the Purchase Option Period expires unexercised or is terminated, a one-time cash payment
of [ * ] as sole consideration for its exercise of the Program Option.

          (d) The Parties hereby agree that, promptly following the Program Option Closing Date, they
shall amend the Novated and Restated Technology License Agreement and such other Operative
Documents as may be required to reflect that the Licensed Intellectual Property related solely to
the applicable Program shall thereafter be the sole and exclusive property of Dynavax or its
assignee or licensee. The Parties further agree that, following the Program Option Closing Date,
the Development Committee shall reallocate to the remaining Programs any and all funds which would
have otherwise been allocated to the Program subject to the Program Option.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

12

 

          (e) Within [ * ] after the Program Option Closing Date, Symphony Dynamo shall transfer and
deliver to Dynavax any and all materials, documents, files and other information relating to the
applicable Program (or, where necessary, copies thereof if such materials, documents, files or
other information are also related to Programs that are not the subject of the Program Option),
including without limitation, any and all administrative files relating to the applicable Program,
and, to the extent applicable, any and all clinical and protocol results, analytical methodologies,
bulk and final product manufacturing processes, batch records, vendor information, validation
documentation, regulatory documentation, patent information, regulatory filings, transfer of
information related to regulatory information and filings, pre-clinical and clinical data, adverse
event data, regulatory correspondence, analyses, and manufacturing data. Subject to Dynavax’s
closing of the Program Option on the Program Option Closing Date, Symphony Dynamo hereby assigns to
Dynavax all such materials and other information.

     11.2 Symphony Dynamo’s Hepatitis B Program Option.

          (a) Dynavax hereby agrees that, upon the occurrence of either:

               (i) [ * ]; or

               (ii) [ * ];

then Dynavax shall (x) [ * ], and (y) [ * ].

          (b) If an event described in Section 11.2(a)(i) or 11.2(a)(ii) shall occur,
and Dynavax shall be unable to fulfill the requirements of clauses (x) and (y) of
Section 11.2(a), then the Symphony Dynamo Board (acting on behalf of Symphony Dynamo) shall
have the option to
require Dynavax to [ * ]. The [ * ] shall be delivered to Dynavax on a Business Day, and
shall thereafter be deemed for all purposes under the terms of this Agreement to be a [ * ], in
accordance with the provisions of [ * ]; provided, that upon its receipt of the [ * ],
Dynavax may [ * ].

     11.3 Discontinuation Option.

          (a) A Program may only be discontinued in accordance with Section 4.2(c) hereof. In
the event of such a Program discontinuation during the Term, (i) Symphony Dynamo shall so notify
Dynavax promptly and in writing of such discontinuation, and (ii) Dynavax shall have the right and
option (a “Discontinuation Option”), exercisable for [ * ] days after receipt of such written
notice from Symphony Dynamo, to buy back the Licensed Intellectual Property related to such
discontinued Program for a deferred purchase price, the payment of which shall be contingent upon
the termination or unexercised expiration of the Purchase Option (the “Discontinuation Price”).
The Discontinuation Price, if any, [ * ], and [ * ]. Following the unexercised expiration of the
Discontinuation Option, Symphony Dynamo may transfer or license its rights to such Program to a
third party at any time prior to the expiration of the Term. Under no circumstances may Symphony
Dynamo or Dynavax (unless Dynavax has exercised a Discontinuation Option in respect of such
Program) reinitiate work on a discontinued Program.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

13

 

          (b) In the event that, following the Discontinuation Closing Date, either Party objects to the
calculation of the portion of the Committed Capital expended on the development of the Program
subject to the Discontinuation Option as used to determine the final Discontinuation Price (the
“Discontinuation Program Funding”), then, within [ * ] of the Discontinuation Closing Date, such
objecting Party shall provide written notice to the other Party (a “Discontinuation Price Dispute
Notice”) specifying the amount disputed and the basis for the dispute, together with supporting
documentation reflecting the analysis of and justification for any re-computation made. In the
event that a Discontinuation Price Dispute Notice is issued by either Party, such dispute shall be
resolved in accordance with the terms of Section 11.3(c). The Discontinuation Price shall
be final, binding and conclusive, shall be non-appealable and shall not be subject to further
review if the disputing Party does not deliver a Discontinuation Price Dispute Notice within such [
* ] period. For the avoidance of doubt, nothing in this Section 11.3(b) shall restrict or
delay the Parties’ performance of those activities identified in this Agreement or the Novated and
Restated Technology License Agreement as taking place following the exercise of the Discontinuation
Option.

          (c) In the event that either Party delivers to the other a Discontinuation Price Dispute
Notice within the time limit set forth in Section 11.3(b), then both Parties shall make
good faith efforts to resolve any dispute relating to the calculation of the Discontinuation
Program Funding through negotiations for a period of [ * ] following the date on which a
Discontinuation Price Dispute Notice is delivered. If the Parties agree on the calculation of the
Discontinuation Program Funding (or a revision thereto) before or within such [ * ] period, and (x)
the recalculated Discontinuation Program Funding results in a recalculated Discontinuation Price
(including as revised through negotiations) that is less than the Discontinuation Price paid on the
Discontinuation Closing Date, then Symphony Dynamo shall promptly, and in any event
within [ * ] of the date on which the Discontinuation Price recalculation becomes final, pay
to Dynavax the amount by which the recalculated Discontinuation Price is less than Discontinuation
Price paid on the Discontinuation Closing Date, or (y) the recalculated Discontinuation Program
Funding results in a recalculated Discontinuation Price (including as revised through negotiations)
that is greater than the Discontinuation Price paid on the Discontinuation Closing Date, then
Dynavax shall promptly, and in any event within [ * ] of the date on which the recalculated
Discontinuation Price becomes final, pay to Symphony Dynamo the amount by which the recalculated
Discontinuation Price is greater than the Discontinuation Price paid on the Discontinuation Closing
Date. In the event that neither of the conditions set forth in the previous clauses (x) and (y)
exist, then no payment shall be made. To the extent that any matter remains unresolved following
negotiations during such [ * ] period (as determined by notice by any Party to the other Party),
the Parties shall jointly select an independent accountant of recognized national standing to
resolve any remaining disagreements, which independent accountant shall not have provided services
to either of the Parties or any of their respective Affiliates during the five-year period
preceding the date of its selection (the “Independent Accountant”). The Parties shall use their
respective commercially reasonable efforts to cause such Independent Accountant to make its
determination of the Discontinuation Price (the “Final Discontinuation Price”) within [ * ] days of
accepting its selection. The decision of the Independent Accountant shall be a final, binding and
conclusive resolution of the Parties’ dispute, shall be non-appealable and shall not be subject to
further review. The costs and expenses of the Independent Accountant shall be split between the
Parties equally.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

14

 

Notwithstanding the foregoing, in any case, each Party shall be responsible for
the payment of its respective costs and expenses, including any attorneys’ and accountants’ fees
(other than any accountants’ fees payable to the Independent Accountant) incurred in connection
with the dispute. If the Final Discontinuation Price is less than the Discontinuation Price paid
on the Discontinuation Closing Date, then Symphony Dynamo shall promptly, and in any event within [
* ] of the date on which the Independent Accountant makes its determination of the Final
Discontinuation Price, pay to Dynavax the amount by which the Final Discontinuation Price is less
than the Discontinuation Price paid on the Discontinuation Closing Date. If the Final
Discontinuation Price is greater than the Discontinuation Price paid on the Discontinuation Closing
Date, then Dynavax shall promptly, and in any event within [ * ] of the date on which the
Independent Accountant makes its determination of the Final Discontinuation Price, pay to Symphony
Dynamo the amount by which the Final Discontinuation Price is greater than the Discontinuation
Price paid on the Discontinuation Closing Date. In the event that neither of the conditions set
forth in the previous two sentences exist, then no payment shall be made.

     11.4 Related Oncology Product Licensing. If, prior to the exercise, unexercised expiration or
termination of the Purchase Option, Dynavax enters into a development or license agreement with one
or more third parties (such an agreement, a “Related Oncology Products Agreement”) [ * ], then [ * ].

	12.	 	Representations and Warranties.

     12.1 Dynavax Representations and Warranties. Dynavax hereby represents and warrants to Symphony Dynamo and Holdings that, as of the
Closing Date:

          (a) Organization. Dynavax is a corporation, duly organized, validly existing and in
good standing under the laws of the State of Delaware.

          (b) Authority and Validity. Dynavax has all requisite corporate power and authority
to execute, deliver and perform its obligations under this Agreement and the Novated and Restated
Technology License Agreement, and to consummate the transactions contemplated thereby. The
execution, delivery and performance by Dynavax of this Agreement and the Novated and Restated
Technology License Agreement and the consummation of the transactions contemplated thereby have
been duly and validly authorized by all necessary action required on the part of Dynavax, and no
other proceedings on the part of Dynavax are necessary to authorize this Agreement or the Novated
and Restated Technology License Agreement or for Dynavax to perform its obligations under this
Agreement or the Novated and Restated Technology License Agreement. This Agreement and the Novated
and Restated Technology License Agreement constitute the lawful, valid and legally binding
obligations of Dynavax, enforceable in accordance with their terms, except as the same may be
limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
the enforcement of creditors’ rights generally and general equitable principles regardless of
whether such enforceability is considered in a proceeding at law or in equity.

          (c) No Violation or Conflict. The execution, delivery and performance of this
Agreement and the Novated and Restated Technology License Agreement and the transactions
contemplated thereby do not and will not (i) violate, conflict with or result in the breach of any

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

15

 

provision of the Organizational Documents of Dynavax, (ii) conflict with or violate any law or
Governmental Order applicable to Dynavax or any of its assets, properties or businesses, or (iii)
conflict with, result in any breach of, constitute a default (or event that with the giving of
notice or lapse of time, or both, would become a default) under, require any consent under, or give
to others any rights of termination, amendment, acceleration, suspension, revocation or
cancellation of, or result in the creation of any Encumbrance on any of the assets or properties of
Dynavax, pursuant to, any note, bond, mortgage or indenture, contract, agreement, lease, sublease,
license, permit, franchise or other instrument or arrangement to which Dynavax is a party except,
in the case of clauses (ii) and (iii), to the extent that such conflicts, breaches, defaults or
other matters would not, individually or in the aggregate, reasonably be expected to have a
Material Adverse Effect on Dynavax or a material adverse effect on the Programs.

          (d) Governmental Consents and Approvals. The execution, delivery and performance of
this Agreement and the Novated and Restated Technology License Agreement by Dynavax do not, and the
consummation of the transactions contemplated thereby do not and will not, require any Governmental
Approval which has not already been obtained, effected or provided, except with respect to which
the failure to so obtain, effect or provide would not, individually or in the aggregate, reasonably
be expected to have a Material Adverse Effect on Dynavax or a material adverse effect on the
Programs.

          (e) Litigation. There are no actions by or against Dynavax pending before any
Governmental Authority or, to the knowledge of Dynavax, threatened to be brought by or
before any Governmental Authority, that would, individually or in the aggregate, reasonably be
expected to have a Material Adverse Effect on Dynavax. There are no pending or, to the knowledge
of Dynavax, threatened actions, to which Dynavax is a party (or is threatened to be named as a
party) to set aside, restrain, enjoin or prevent the execution, delivery or performance of this
Agreement or the Operative Documents or the consummation of the transactions contemplated hereby or
thereby by any party hereto or thereto. Dynavax is not subject to any Governmental Order (nor, to
the knowledge of Dynavax, is there any such Governmental Order threatened to be imposed by any
Governmental Authority) that would, individually or in the aggregate, reasonably be expected to
have a Material Adverse Effect on Dynavax or a material adverse effect on the Programs.

          (f) No Contracts. Except as disclosed on part “A” of Schedule 12.1(f) hereto,
there are no material contracts between Dynavax and any third party, including contractors,
manufacturers or suppliers, used with or otherwise necessary for the Programs, and all such
contracts are assignable to Symphony Dynamo with the consent of such third party, in each case [ *
], such consent not to be unreasonably withheld. Except as disclosed on part “B” of Schedule
12.1(f) hereto, to the knowledge of Dynavax, there are no contracts between Dynavax and any
third party that, if not assigned to Symphony Dynamo following the termination of this Agreement
without exercise of the Purchase Option, would have a material adverse effect on any of the
Programs or on Symphony Dynamo’s rights under the Novated and Restated Technology License
Agreement.

     12.2 Symphony Dynamo Representations and Warranties. Symphony Dynamo hereby represents and
warrants to Dynavax that, as of the Closing Date:

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

16

 

          (a) Organization. Symphony Dynamo is a corporation, duly organized, validly existing
and in good standing under the laws of the State of Delaware.

          (b) Authority and Validity. Symphony Dynamo has all requisite corporate power and
authority to execute, deliver and perform its obligations under this Agreement and the Novated and
Restated Technology License Agreement and to consummate the transactions contemplated thereby. The
execution, delivery and performance by Symphony Dynamo of this Agreement and the Novated and
Restated Technology License Agreement and the consummation of the transactions contemplated thereby
have been duly and validly authorized by all necessary action required on the part of Symphony
Dynamo, and no other proceedings on the part of Symphony Dynamo are necessary to authorize this
Agreement or the Novated and Restated Technology License Agreement or for Symphony Dynamo to
perform its obligations under this Agreement or the Novated and Restated Technology License
Agreement. This Agreement and the Novated and Restated Technology License Agreement constitute the
lawful, valid and legally binding obligations of Symphony Dynamo, enforceable in accordance with
its terms, except as the same may be limited by applicable bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting the enforcement of creditors’ rights generally and general
equitable principles regardless of whether such enforceability is considered in a proceeding at law
or in equity.

          (c) No Violation or Conflict. The execution, delivery and performance of this
Agreement and the Novated and Restated Technology License Agreement and the transactions
contemplated thereby do not and will not (i) violate, conflict with or result in the breach of any
provision of the Organizational Documents of Symphony Dynamo, (ii) conflict with or violate any law
or Governmental Order applicable to Symphony Dynamo or any of its assets, properties or businesses,
or (iii) conflict with, result in any breach of, constitute a default (or event that with the
giving of notice or lapse of time, or both, would become a default) under, require any consent
under, or give to others any rights of termination, amendment, acceleration, suspension, revocation
or cancellation of, or result in the creation of any Encumbrance on any of the assets or properties
of Symphony Dynamo, pursuant to, any note, bond, mortgage or indenture, contract, agreement, lease,
sublease, license, permit, franchise or other instrument or arrangement to which Symphony Dynamo is
a party except, in the case of clauses (ii) and (iii), to the extent that such conflicts, breaches,
defaults or other matters would not, individually or in the aggregate, reasonably be expected to
have a Material Adverse Effect on Symphony Dynamo.

          (d) Governmental Consents and Approvals. The execution, delivery and performance of
this Agreement and the Novated and Restated Technology License Agreement by Symphony Dynamo do not,
and the consummation of the transactions contemplated thereby do not and will not, require any
Governmental Approval which has not already been obtained, effected or provided, except with
respect to which the failure to so obtain, effect or provide would not, individually or in the
aggregate, reasonably be expected to have a Material Adverse Effect on Symphony Dynamo.

          (e) Litigation. There are no actions by or against Symphony Dynamo pending before any
Governmental Authority or, to the knowledge of Symphony Dynamo, threatened to be brought, by or
before any Governmental Authority that would, individually or in the aggregate, reasonably be
expected to have a Material Adverse Effect on Symphony Dynamo.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

17

 

There are no pending or, to the
knowledge of Symphony Dynamo, threatened actions to which Symphony Dynamo is a party (or is
threatened to be named as a party) to set aside, restrain, enjoin or prevent the execution,
delivery or performance of this Agreement or the Operative Documents or the consummation of the
transactions contemplated hereby or thereby by any party hereto or thereto. Symphony Dynamo is not
subject to any Governmental Order (nor, to the knowledge of Symphony Dynamo, is there any such
Governmental Order threatened to be imposed by any Governmental Authority) that would, individually
or in the aggregate reasonably be expected to have a Material Adverse Effect on Symphony Dynamo or
a material adverse effect on the Programs.

	13.	 	Relationship Between Dynavax and Symphony Dynamo. Nothing contained in this Agreement or any
acts or omissions hereunder shall constitute or be construed so as to create any joint venture
or partnership relationship between Dynavax and Symphony Dynamo, and the Parties acknowledge
and agree that Dynavax is acting as an independent contractor in the performance of its
obligations under this Agreement.
	 
	14.	 	Change of Control. Dynavax will not, at any time during the Term, undergo a Change of
Control, unless:

          (a) the Surviving Entity [ * ]; or

          (b) such Surviving Entity shall (i) [ * ]; (ii) have provided to Symphony Dynamo and Holdings
an opinion of nationally recognized outside counsel to the effect that (A) the [ * ] referred to in
clause (i) above are [ * ], and (B) such Change of Control does not [ * ]; (iii) [ * ], except to
the extent that failure to make such [ * ] would not reasonably be expected to have a material
adverse effect on the Programs or Symphony Dynamo’s rights under the Operative Documents; and (iv)
have arranged for an appropriate senior executive of the Surviving Entity to [ * ], as well as the
strategic importance of the [ * ] to the Surviving Entity.

	15.	 	No Restrictions; Indemnification.

     15.1 No Restrictions. Nothing in this Agreement shall limit or restrict the right of any
director, officer or employee of Dynavax or any director, officer, or employee of any of its
subsidiaries or its Affiliates to engage in any other business or to devote his or her time and
attention to the management or other aspects of any other business, whether of a similar or
dissimilar nature, nor limit or restrict the right of Dynavax or any of its affiliates to engage in
any other business or to render services of any kind to any other Person.

     15.2 Indemnification.

          (a) To the greatest extent permitted by applicable law, Dynavax shall indemnify and hold
harmless Symphony Dynamo and RRD and each of their respective Affiliates, officers, directors,
employees, agents, members, managers, successors and assigns (each, a “Symphony Indemnified
Party”), and Symphony Dynamo shall indemnify and hold harmless Dynavax, and its Affiliates and each
of their respective officers, directors, employees, agents (other than Dynavax Subcontractors),
members, managers, successors and assigns (each, a “Dynavax Indemnified Party”), from and against
any and all claims, losses, costs, interest,

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

18

 

awards, judgments, penalties, fees (including
reasonable fees for attorneys and other professionals), court costs, liabilities, damages and
expenses incurred by any Symphony Indemnified Party or Dynavax Indemnified Party (irrespective of
whether any such Indemnified Party is a party to the action for which indemnification hereunder is
sought) (hereinafter, a “Loss”) as a result of, or arising out of, or relating to any and all third
party suits, claims, actions, proceedings or demands based upon:

               (i) in the case of Dynavax being the Indemnifying Party, (A) any breach of any representation
or warranty made by Dynavax herein or in any certificate, instrument or document delivered in
connection and contemporaneously herewith, (B) any breach of any covenant, agreement or obligation
of Dynavax contained herein, or in any certificate, instrument or document delivered hereunder,
except to the extent such covenant, agreement or obligation relates to Dynavax’s performance under
the Development Plan, (C) any
gross negligence or willful misconduct of Dynavax or its Dynavax Subcontractors in connection
with Dynavax’s or its Dynavax Subcontractors’ performance of Dynavax’s obligations under this
Agreement (including the Development Plan), (D) any action undertaken or performed by or on behalf
of Dynavax prior to, and including, the Closing Date that relates to the Programs or the Products,
or (E) in the event Licensor exercises a Discontinuation Option or Program Option for a Program,
any action undertaken and/or performed by or on behalf of Licensor after the Discontinuation
Closing Option Date or the Program Option Closing Date and relating to the Product that was the
subject of such Program (including the development, manufacture, use, handling, storage, sale or
other disposition of such Product); in each case, except (1) with respect to Losses for which
Dynavax is entitled to indemnification under this Article 15, or (2) to the extent such
Loss arises from the gross negligence or willful misconduct of a Symphony Indemnified Party; and

               (ii) in the case of Symphony Dynamo being the Indemnifying Party, (A) any breach of any
representation or warranty made by Symphony Dynamo herein or in any certificate, instrument or
document delivered in connection and contemporaneously herewith, (B) any breach of any covenant,
agreement or obligation of Symphony Dynamo contained herein or in any certificate, instrument or
document delivered hereunder, (C) any and all activities by or on behalf of the Parties under the
Development Plan (including (1) any activities performed by RRD pursuant to the RRD Services
Agreement and (2) any claim arising out of any condition caused by the Products after the Closing
Date but prior to the expiration of the Term), (D) any gross negligence or willful misconduct of
Symphony Dynamo or its direct subcontractors in connection with Symphony Dynamo’s or its direct
subcontractors’ performance of its obligations under this Agreement, or (E) the development,
manufacture, use, handling, storage, sale or other disposition of the Products (including in the
course of conducting the Programs) during the Term (except with respect to the development,
manufacture, use, handling, storage, sale or other disposition, after Dynavax’s exercise of the
Discontinuation Option or the Program Option as applicable, of Products covered under Section
15.2(a)(i)(E)); in each case, except (1) with respect to Losses for which Symphony Dynamo is
entitled to indemnification under this Article 15, or (2) Losses deemed to have arisen from
the breach by Dynavax of any covenant, agreement or obligation under this Agreement that relates to
Dynavax’s performance under the Development Plan, as determined by a court, arbitrator or pursuant
to a settlement agreement, or (3) to the extent such Loss arises from the gross negligence or
willful misconduct of a Dynavax

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

19

 

Indemnified Party. Solely for the purposes of claims arising under
(C) above, Dynavax Subcontractors shall also be deemed to be Dynavax Indemnified Parties.

To the extent that the foregoing undertaking by Dynavax or Symphony Dynamo may be unenforceable for
any reason, such Party shall make the maximum contribution to the payment and satisfaction of any
Loss that is permissible under applicable law.

          (b) Notice of Claims. Any Indemnified Party that proposes to assert a right to be
indemnified under this Section 15.2 shall notify Dynavax or Symphony Dynamo, as applicable
(the “Indemnifying Party”), promptly after receipt of notice of commencement of any action, suit or
proceeding against such Indemnified Party (an “Indemnified Proceeding”) in respect of which a claim
is to be made under this Section 15.2, or the incurrence or realization of any Loss in
respect of which a claim is to be made under this Section 15.2, of the
commencement of such Indemnified Proceeding or of such incurrence or realization, enclosing a
copy of all relevant documents, including all papers served and claims made, but the omission so to
notify the applicable Indemnifying Party promptly of any such Indemnified Proceeding or incurrence
or realization shall not relieve (x) such Indemnifying Party from any liability that it may have to
such Indemnified Party under this Section 15.2 or otherwise, except, as to such
Indemnifying Party’s liability under this Section 15.2, to the extent, but only to the
extent, that such Indemnifying Party shall have been prejudiced by such omission, or (y) any other
indemnitor from liability that it may have to any Indemnified Party under the Operative Documents.

          (c) Defense of Proceedings. In case any Indemnified Proceeding shall be brought
against any Indemnified Party, it shall notify the applicable Indemnifying Party of the
commencement thereof as provided in Section 15.2(b), and such Indemnifying Party shall be
entitled to participate in, and provided such Indemnified Proceeding involves a claim solely for
money damages and does not seek an injunction or other equitable relief against the Indemnified
Party and is not a criminal or regulatory action, to assume the defense of, such Indemnified
Proceeding with counsel reasonably satisfactory to such Indemnified Party. After notice from such
Indemnifying Party to such Indemnified Party of such Indemnifying Party’s election so to assume the
defense thereof and the failure by such Indemnified Party to object to such counsel within ten (10)
Business Days following its receipt of such notice, such Indemnifying Party shall not be liable to
such Indemnified Party for legal or other expenses related to such Indemnified Proceedings incurred
after such notice of election to assume such defense except as provided below and except for the
reasonable costs of investigating, monitoring or cooperating in such defense subsequently incurred
by such Indemnified Party reasonably necessary in connection with the defense thereof. Such
Indemnified Party shall have the right to employ its counsel in any such Indemnified Proceeding,
but the reasonable fees and expenses of such counsel shall be at the expense of such Indemnified
Party unless:

               (i) the employment of counsel by such Indemnified Party at the expense of the applicable
Indemnifying Party has been authorized in writing by such Indemnifying Party;

               (ii) such Indemnified Party shall have reasonably concluded in its good faith (which
conclusion shall be determinative unless a court determines that such

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

20

 

conclusion was not reached
reasonably and in good faith) that there is or may be a conflict of interest between the applicable
Indemnifying Party and such Indemnified Party in the conduct of the defense of such Indemnified
Proceeding or that there are or may be one or more different or additional defenses, claims,
counterclaims, or causes of action available to such Indemnified Party (it being agreed that in any
case referred to in this clause (ii) such Indemnifying Party shall not have the right to
direct the defense of such Indemnified Proceeding on behalf of the Indemnified Party);

               (iii) the applicable Indemnifying Party shall not have employed counsel reasonably acceptable
to the Indemnified Party to assume the defense of such Indemnified Proceeding within a reasonable
time after notice of the commencement thereof, it being agreed that in any case referred to in this
clause (iii) such Indemnifying Party shall not have the right to direct the defense of such
Indemnified Proceeding on behalf of the Indemnified Party and that
this clause (iii) shall not be deemed to constitute a waiver of any conflict of
interest that may arise with respect to any such counsel); or

               (iv) any counsel employed by the applicable Indemnifying Party shall fail to timely commence
or diligently conduct the defense of such Indemnified Proceeding and such failure has materially
prejudiced (or, in the reasonable judgment of the Indemnified Party, is in danger of materially
prejudicing) the outcome of such Indemnified Proceeding;

in each of which cases the reasonable fees and expenses of counsel for such Indemnified Party shall
be at the expense of such Indemnifying Party. Only one counsel shall be retained by all
Indemnified Parties with respect to any Indemnified Proceeding, unless counsel for any Indemnified
Party reasonably concludes in good faith (which conclusion shall be determinative unless a court
determines that such conclusion was not reached reasonably and in good faith) that there is or may
be a conflict of interest between such Indemnified Party and one or more other Indemnified Parties
in the conduct of the defense of such Indemnified Proceeding or that there are or may be one or
more different or additional defenses, claims, counterclaims, or causes or action available to such
Indemnified Party.

          (d) Settlement. Without the prior written consent of such Indemnified Party, such
Indemnifying Party shall not settle or compromise, or consent to the entry of any judgment in, any
pending or threatened Indemnified Proceeding, unless such settlement, compromise, consent or
related judgment (i) includes an unconditional release of such Indemnified Party from all liability
for Losses arising out of such claim, action, investigation, suit or other legal proceeding, (ii)
provides for the payment of money damages as the sole relief for the claimant (whether at law or in
equity), (iii) involves no finding or admission of any violation of law or the rights of any Person
by the Indemnified Party, and (iv) is not in the nature of a criminal or regulatory action. No
Indemnified Party shall settle or compromise, or consent to the entry of any judgment in, any
pending or threatened Indemnified Proceeding in respect of which any payment would result hereunder
or under the Operative Documents without the prior written consent of the Indemnifying Party, such
consent not to be unreasonably conditioned, withheld or delayed.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

21

 

	16.	 	LIMITATION OF LIABILITIES.

     16.1 Between the Parties. TO THE GREATEST EXTENT PERMITTED BY APPLICABLE LAW, NEITHER PARTY
NOR ANY OF THEIR RESPECTIVE DIRECTORS, OFFICERS, MEMBERS, MANAGERS, EMPLOYEES, INDEPENDENT
CONTRACTORS OR AGENTS (INCLUDING RRD AND ITS MEMBERS, MANAGERS, EMPLOYEES, INDEPENDENT CONTRACTORS
AND AGENTS) SHALL HAVE ANY LIABILITY OF ANY TYPE (INCLUDING, BUT NOT LIMITED TO, CLAIMS IN
CONTRACT, NEGLIGENCE AND TORT LIABILITY) FOR ANY SPECIAL, INCIDENTAL, INDIRECT OR CONSEQUENTIAL
DAMAGES, INCLUDING, BUT NOT LIMITED TO, THE LOSS OF OPPORTUNITY, LOSS OF USE OR LOSS OF REVENUE OR
PROFIT IN CONNECTION WITH OR ARISING OUT OF THIS
AGREEMENT OR THE SERVICES PERFORMED HEREUNDER, EVEN IF SUCH DAMAGES MAY HAVE BEEN FORESEEABLE.
THE FOREGOING SHALL NOT LIMIT EITHER PARTY’S INDEMNIFICATION OBLIGATIONS PURSUANT TO SECTION
15.2 AND SHALL NOT APPLY TO BREACHES OF ITS CONFIDENTIALITY OBLIGATIONS PURSUANT TO ARTICLE
10.

     16.2 Pursuant to the RRD Services Agreement. Each Party hereby acknowledges and agrees that,
pursuant to Sections 9(f) and (g) of the RRD Services Agreement, RRD has expressly disclaimed all
liability for (a) any claim arising out of, or allegedly arising out of the activities carried out
by (or within the authority of) Dynavax (and such Dynavax Subcontractors and vendors it may retain)
hereunder, or for any liability arising under the Novated and Restated Technology License Agreement
with respect to any license or sublicense thereunder in relation to the activities carried out by
(or within the authority of) Dynavax (and such Dynavax Subcontractors and vendors it may retain)
hereunder, and (b) supervising, compensating or discharging, or any other liability to or with
respect to, any vendor retained by Dynavax (or, in the case of a vendor engaged by both RRD and
Dynavax, to and for such vendor to the extent that such vendor performs services for Dynavax),
except that RRD shall make payments from Symphony Dynamo’s funds to reimburse Dynavax, in
accordance with Article 8 and Annex E of this Agreement, for costs and expenses
incurred by Dynavax in connection with the engagement of such vendors by Dynavax for the
performance of services contemplated under the Development Plan.

	17.	 	Term and Termination.

     17.1 Term. This Agreement shall be effective as of the Closing Date and shall expire on the
last day of the Term, unless the Agreement is earlier terminated as specified in this Article
17.

     17.2 Termination for Dynavax’s Breach.

          (a) Symphony Dynamo may terminate this Agreement at any time upon written notice to Dynavax if
Dynavax is in material default or breach of this Agreement, and such material default or breach
continues unremedied for a period of [ * ] days after written notice thereof is delivered to
Dynavax. Such cure period may be extended if (i) Dynavax reasonably believes such breach can be
cured within [ * ] days of Dynavax’s receipt of Symphony Dynamo’s written notice of such breach
(and notifies Symphony Dynamo in writing

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

22

 

of such belief and the basis for such belief), and (ii)
Symphony Dynamo, acting reasonably, agrees. If Dynavax fails to remedy the default or breach
within the applicable cure period, Symphony Dynamo may by final notice of termination to Dynavax
terminate this Agreement.

          (b) In the event that Symphony Dynamo terminates this Agreement pursuant to Section
17.2(a) above, Dynavax may exercise its Purchase Option, pursuant to Section 1(c)(iv) of the
Purchase Option Agreement, within [ * ] of receiving such final notice of termination from Symphony
Dynamo; provided, that if such termination occurs after a Change of Control with respect to
Dynavax has occurred, and solely in the event that the successor entity chooses not to exercise its
Purchase Option, then Holdings may exercise its Put Option pursuant to Section 2A of the Purchase
Option Agreement.

     17.3 Termination for Symphony Dynamo’s Breach(a) . Dynavax may terminate this Agreement at
any time upon written notice to Symphony Dynamo if Symphony Dynamo is in material default or breach
of this Agreement, and such material default or breach continues unremedied for a period of [ * ]
days after written notice thereof is delivered to Symphony Dynamo. Such cure period may be
extended if (i) Symphony Dynamo reasonably believes such breach can be cured within [ * ] days of
Symphony Dynamo’s receipt of Dynavax’s written notice of such breach (and notifies Dynavax in
writing of such belief and the basis for such belief), and (ii) Dynavax, acting reasonably, agrees.
If Symphony Dynamo fails to remedy the default or breach within the applicable cure period,
Dynavax may by final notice of termination to Symphony Dynamo terminate this Agreement.

     17.4 Termination of License Agreement. This Agreement shall automatically terminate upon the
termination of the Novated and Restated Technology License Agreement.

     17.5 Survival.

          (a) The agreements and covenants of the Parties set forth in Articles 10, 11,
15, 16 and 18, and Sections 6.7 and 17.5 shall survive the
expiration or termination of this Agreement. In addition, Section 8.2 shall, to the
extent that the costs and expenses reimbursable thereunder have been incurred or become
uncancellable prior to such termination, also survive such expiration.

          (b) If Dynavax does not exercise the Purchase Option, in addition to the provisions specified
in Section 17.5(a), then Section 5.4 shall also survive such unexercised
expiration.

	18.	 	Miscellaneous.

     18.1 No Petition. Dynavax covenants and agrees that, prior to the date which is one (1) year
and one (1) day after the expiration of the Term, Dynavax will not institute or join in the
institution of any bankruptcy, insolvency, reorganization or similar proceeding against Symphony Dynamo. The
provisions of this Section 18.1 shall survive the termination of this Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

23

 

     18.2 Notices. Any notice, request, demand, waiver, consent, approval or other communication
which is required or permitted to be given to any Party shall be in writing and shall be deemed
given only if delivered to the Party personally or sent to the Party by facsimile transmission
(promptly followed by a hard-copy delivered in accordance with this Section 18.2), by next
Business Day delivery by a nationally recognized courier service, or by registered or certified
mail (return receipt requested), with postage and registration or certification fees thereon
prepaid, addressed to the Party at its address set forth below:

Dynavax:

Dynavax Technologies Corporation

2929 Seventh Street, Suite 100

Berkeley, CA 94710

Attn: Deborah Smeltzer, VP, Operations & CFO

Facsimile: (510) 848-1327

Symphony Dynamo:

Symphony Dynamo, Inc.

7361 Calhoun Place, Suite 325

Rockville, MD 20850

Attn: Charles W. Finn, Ph.D.

Facsimile: (301) 762-6154

Holdings:

Symphony Dynamo Holdings LLC

7361 Calhoun Place, Suite 325

Rockville, MD 20850

Attn: Joseph P. Clancy

Facsimile: (301) 762-6154

with copies to:

Symphony Capital Partners, L.P.

875 Third Avenue

18th Floor

New York, NY 10022

Attn: Mark Kessel

Facsimile: (212) 632-5401

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

24

 

and

Symphony Strategic Partners, LLC

875 Third Avenue

18th Floor

New York, NY 10022

Attn: Mark Kessel

Facsimile: (212) 632-5401

or to such other address as such Party may from time to time specify by notice given in the manner
provided herein to each other Party entitled to receive notice hereunder.

     18.3 Governing Law; Consent to Jurisdiction and Service of Process.

          (a) This Agreement shall be governed by, and construed in accordance with, the laws of the
State of New York.

          (b) Each of the Parties hereby irrevocably and unconditionally submits, for itself and its
property, to the nonexclusive jurisdiction of any New York State court or federal court of the
United States of America sitting in The City of New York, Borough of Manhattan, and any appellate
court from any jurisdiction thereof, in any action or proceeding arising out of or relating to this
Agreement, or for recognition or enforcement of any judgment, and each of the Parties hereby
irrevocably and unconditionally agrees that all claims in respect of any such action or proceeding
may be heard and determined in any such New York State court or, to the fullest extent permitted by
law, in such federal court. Each of the Parties agrees that a final judgment in any such action or
proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment
or in any other manner provided by law. Nothing in this Agreement shall affect any right that any
Party may otherwise have to bring any action or proceeding relating to this Agreement.

          (c) Each of the Parties irrevocably and unconditionally waives, to the fullest extent it may
legally and effectively do so, any objection that it may now or hereafter have to the laying of
venue of any suit, action or proceeding arising out of or relating to this Agreement in any New
York State or federal court. Each of the Parties hereby irrevocably waives, to the fullest extent
permitted by law, the defense of an inconvenient forum to the maintenance of such action or
proceeding in any such court.

     18.4 WAIVER OF JURY TRIAL. EACH OF THE PARTIES HERETO IRREVOCABLY WAIVES ALL RIGHT TO TRIAL
BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE)
ARISING OUT OF OR RELATING TO THIS AGREEMENT.

     18.5 Entire Agreement. This Agreement (including any Annexes, Schedules, Exhibits or other attachments hereto)
constitutes the entire agreement between the Parties with respect to the matters covered hereby,
and no oral or written statement may be used to interpret or vary the meaning of the terms and
conditions hereof. This Agreement supersedes all prior

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

25

 

agreements and understanding with respect
to such matters between the Parties, including the Research and Development Agreement but excluding
the Operative Documents.

     18.6 Amendment; Successors; Assignment; Counterparts.

          (a) The terms of this Agreement shall not be altered, modified, amended, waived or
supplemented in any manner whatsoever except by a written instrument signed by each of the Parties.

          (b) Nothing expressed or implied herein is intended or shall be construed to confer upon or to
give to any Person, other than the Parties (and, to the extent of Section 18.8, RRD), any
right, remedy or claim under or by reason of this Agreement or of any term, covenant or condition
hereof, and all the terms, covenants, conditions, promises and agreements contained herein shall be
for the sole and exclusive benefit of the Parties (and, to the extent of Section 18.8,
RRD), and their successors and permitted assigns.

          (c) This Agreement may not be assigned by either Party hereto without the prior written
consent of the other part; provided, that, in the event Dynavax undergoes a Change of
Control in compliance with Article 14 hereof, Dynavax may assign this Agreement to its
Successor Entity.

          (d) This Agreement may be executed in one or more counterparts, each of which, when executed,
shall be deemed an original but all of which taken together shall constitute one and the same
Agreement.

     18.7 Severability. If any term or other provision of this Agreement is invalid, illegal or
incapable of being enforced by any rule of law or public policy, all other conditions and
provisions of this Agreement shall nevertheless remain in full force and effect so long as the
economic or legal substance of the transactions contemplated hereby is not affected in a manner
materially adverse to either party. Upon such determination that any term or other provision is
invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith
to modify this Agreement so as to effect the original intent of the parties as closely as possible
in an acceptable manner to the end that the transactions contemplated hereby are fulfilled to the
extent possible.

     18.8 Third Party Beneficiary. Each of the Parties agrees that RRD shall be a third party
beneficiary of Articles 2, 8 and 16, and Sections 4.1,
4.2(a), 4.2(b), 7.1, 9.1(f), 15.2 and 18.6(b) of
this Agreement.

{SIGNATURES FOLLOW ON NEXT PAGE}

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

26

 

          IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be executed as of the day
and year above written.

	 	 	 
	SYMPHONY DYNAMO HOLDINGS LLC
	 
	 	 
	By:

	 	Symphony Capital Partners, L.P.,
	 

	 	its Manager
	 
	 	 
	By:

	 	Symphony Capital GP, L.P.,
	 

	 	its general partner
	 
	 	 
	By:

	 	Symphony GP, LLC,
	 

	 	its general partner

	 	 	 	 	 
	By:

	 	/s/ Mark Kessel
 

Name: Mark Kessel
	 	 
	 

	 	Title: Managing Member	 	 
	 
	 	 	 	 
	SYMPHONY DYNAMO, INC.	 	 
	 
	 	 	 	 
	By:

	 	/s/ Harri V. Taranto	 	 
	 

	 	 	 	 
	 

	 	Name: Harri V. Taranto	 	 
	 

	 	Title: Chairman of the Board	 	 
	 
	 	 	 	 
	DYNAVAX TECHNOLOGIES CORPORATION	 	 
	 
	 	 	 	 
	By:

	 	/s/ Dino Dina	 	 
	 

	 	 	 	 
	 

	 	Name: Dino Dina, M.D.	 	 
	 

	 	Title: President & Chief Executive Officer	 	 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Amended and Restated R&D Agreement

 

 

SCHEDULE 12.1(f)

MATERIAL CONTRACTS

[ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN
OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Schedule 12.1(f) to the

Amended and Restated R&D Agreement

 

 

ANNEX A

CERTAIN DEFINITIONS

          “$” means United States dollars.

          “Accredited Investor” has the meaning set forth in Rule 501(a) of Regulation D promulgated
under the Securities Act of 1933, as amended.

          “Act” means the Delaware Limited Liability Company Act, 6 Del. C. § 18-101 et seq.

          “Ad Hoc Meeting” has the meaning set forth in Paragraph 6 of Annex B of the Amended and
Restated Research and Development Agreement.

          “Additional Funds” has the meaning set forth in Section 2(b) of the Funding Agreement.

          “Additional Funding Date” has the meaning set forth in Section 3 of the Funding Agreement.

          “Additional Party” has the meaning set forth in Section 13 of the Confidentiality Agreement.

          “Additional Regulatory Filings” means such Governmental Approvals as required to be made under
any law applicable to the purchase of the Symphony Dynamo Equity Securities under the Purchase
Option Agreement.

          “Adjusted Capital Account Deficit” has the meaning set forth in Section 1.01 of the Holdings
LLC Agreement.

          “Affected Member” has the meaning set forth in Section 27 of the Investors LLC Agreement.

          “Affiliate” means, with respect to any Person (i) any Person directly or indirectly
controlling, controlled by or under common control with such Person, (ii) any officer, director,
general partner, member or trustee of such Person, or (iii) any Person who is an officer, director,
general partner, member or trustee of any Person described in clauses (i) or (ii) of this sentence.
For purposes of this definition, the terms “controlling,” “controlled by” or “under common control
with” shall mean the possession, direct or indirect, of the power to direct or cause the direction
of the management and policies of a Person or entity, whether through the ownership of voting
securities, by contract or otherwise, or the power to elect at least 50% of the directors,
managers, general partners, or persons exercising similar authority with respect to such Person or
entities.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

1

 

          “Amended and Restated Research and Development Agreement” means the Amended and Restated
Research and Development Agreement dated as of the Closing Date, among Dynavax, Holdings and
Symphony Dynamo.

          “Asset Value” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Auditors” means an independent certified public accounting firm of recognized national
standing.

          [ * ]

          “Bankruptcy Code” means the United States Bankruptcy Code.

          “Berna” has the meaning set forth in Section 11.1(a) of the Amended and Restated Research and
Development Agreement.

          “Business Day” means any day other than Saturday, Sunday or any other day on which commercial
banks in The City of New York or the City of San Francisco are authorized or required by law to
remain closed.

          “Cancer Products” mean [ * ].

          “Cancer Program” means the identification, development, manufacture and/or use of any Cancer
Products in accordance with the Development Plan.

          “Capital Contributions” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

          “Capitalized Leases” means all leases that have been or should be, in accordance with GAAP,
recorded as capitalized leases.

          “Cash Available for Distribution” has the meaning set forth in Section 1.01 of the Holdings
LLC Agreement.

          “Chair” has the meaning set forth in Paragraph 4 of Annex B to the Amended and Restated
Research and Development Agreement.

          “Change of Control” means and includes the occurrence of any of the following events, but
specifically excludes (i) acquisitions of capital stock directly from Dynavax for cash, whether in
a public or private offering, (ii) sales of capital stock by stockholders of Dynavax, and (iii)
acquisitions of capital stock by or from any employee benefit plan or related trust:

     (a) the merger, reorganization or consolidation of Dynavax into or with another
corporation or legal entity in which Dynavax’s stockholders holding the right to vote with
respect to matters generally immediately preceding such merger, reorganization

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

2

 

or consolidation, own less than fifty percent (50%) of the voting securities of the
surviving entity; or

          (b) the sale of all or substantially all of Dynavax’s assets or business.

          “Class A Member” means a holder of a Class A Membership Interest.

          “Class A Membership Interest” means a Class A Membership Interest in Holdings.

          “Class B Member” means a holder of a Class B Membership Interest.

          “Class B Membership Interest” means a Class B Membership Interest in Holdings.

          “Class C Member” means a holder of a Class C Membership Interest.

          “Class C Membership Interest” means a Class C Membership Interest in Holdings.

          “Closing Certificate for Section 5.1(e)” means the written certificate, pertaining to the
representations made by Dynavax under Section 5.1(e) of the Novated and Restated Technology License
Agreement, provided by Dynavax to Symphony Dynamo Holdings LLC and Symphony Dynamo on the Closing
Date.

          “Closing Certificate for Section 5.1(f)” means the written certificate, pertaining to the
representations made by Dynavax under Section 5.1(f) of the Novated and Restated Technology License
Agreement, provided by Dynavax to Symphony Dynamo Holdings LLC and Symphony Dynamo on the Closing
Date.

          “Client Schedules” has the meaning set forth in Section 5(b)(i) of the RRD Services Agreement.

          “Clinical Budget Component” has the meaning set forth in Section 4.1 of the Amended and
Restated Research and Development Agreement.

          “Closing Date” means April 18, 2006.

          “CMC” means the chemistry, manufacturing and controls documentation as required for filings
with Regulatory Authority relating to the manufacturing, production and testing of drug products.

          “Code” means the Internal Revenue Code of 1986, as amended from time to time.

          “Committed Capital” means $50,000,000.00.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

3

 

          “Common Stock” means the common stock, par value $0.01 per share, of Symphony Dynamo.

          “Company Expenses” has the meaning set forth in Section 5.09 of the Holdings LLC Agreement.

          “Company Property” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Confidential Information” has the meaning set forth in Section 2 of the Confidentiality
Agreement.

          “Confidentiality Agreement” means the Confidentiality Agreement, dated as of the Closing Date,
among Symphony Dynamo, Holdings, Dynavax, each Symphony Fund, SCP, SSP, Investors, Symphony
Capital, RRD and Ann M. Arvin, M.D.

          “Conflict Transaction” has the meaning set forth in Article X of the Symphony 
Dynamo Charter.

          “Control” means, with respect to any material, information or intellectual property right,
that a Party owns or has a license to such item or right, and has the ability to grant the other
Party access, a license or a sublicense (as applicable) in or to such item or right as provided in
the Operative Documents without violating the terms of any agreement or other arrangement with any
third party.

          “Debt” of any Person means, without duplication:

(a) all indebtedness of such Person for borrowed money,

(b) all obligations of such Person for the deferred purchase price of property or services
(other than any portion of any trade payable obligation that shall not have remained unpaid for
91 days or more from the later of (A) the original due date of such portion and (B) the
customary payment date in the industry and relevant market for such portion),

(c) all obligations of such Person evidenced by bonds, notes, debentures or other similar
instruments,

(d) all obligations of such Person created or arising under any conditional sale or other title
retention agreement with respect to property acquired by such Person (whether or not the rights
and remedies of the seller or lender under such agreement in an event of default are limited to
repossession or sale of such property),

(e) all Capitalized Leases to which such Person is a party,

(f) all obligations, contingent or otherwise, of such Person under acceptance, letter of credit
or similar facilities,

(g) all obligations of such Person to purchase, redeem, retire, defease or otherwise acquire for
value any Equity Securities of such Person,

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

4

 

(h) the net amount of all financial obligations of such Person in respect of Hedge Agreements,

(i) the net amount of all other financial obligations of such Person under any contract or other
agreement to which such Person is a party,

(j) all Debt of other Persons of the type described in clauses (a) through (i) above guaranteed,
directly or indirectly, in any manner by such Person, or in effect guaranteed, directly or
indirectly, by such Person through an agreement (A) to pay or purchase such Debt or to advance
or supply funds for the payment or purchase of such Debt, (B) to purchase, sell or lease (as
lessee or lessor) property, or to purchase or sell services, primarily for the purpose of
enabling the debtor to make payment of such Debt or to assure the holder of such Debt against
loss, (C) to supply funds to or in any other manner invest in the debtor (including any
agreement to pay for property or services irrespective of whether such property is received or
such services are rendered) or (D) otherwise to assure a creditor against loss, and

(k) all Debt of the type described in clauses (a) through (i) above secured by (or for which the
holder of such Debt has an existing right, contingent or otherwise, to be secured by) any
Encumbrance on property (including accounts and contract rights) owned or held or used under
lease or license by such Person, even though such Person has not assumed or become liable for
payment of such Debt.

          “Development Budget” means the budget (comprised of the Management Budget Component and the
Clinical Budget Component) for the implementation of the Development Plan (the initial form of
which was agreed upon by Dynavax and Symphony Dynamo as of the Closing Date and attached to the
Amended and Restated Research and Development Agreement as Annex D thereto), as may be further
developed and revised from time to time in accordance with the Development Committee Charter and
the Amended and Restated Research and Development Agreement.

          “Development Committee” has the meaning set forth in Article 3 of the Amended and Restated
Research and Development Agreement.

          “Development Committee Charter” has the meaning set forth in Article 3 of the Amended and
Restated Research and Development Agreement.

          “Development Committee Member” has the meaning set forth in Paragraph 1 of Annex B to the
Amended and Restated Research and Development Agreement.

          “Development Plan” means the development plan covering all the Programs (the initial form of
which was agreed upon by Dynavax and Symphony Dynamo as of the Closing Date and attached to the
Amended and Restated Research and Development Agreement as Annex C thereto), as may be further
developed and revised from time to time in accordance with the Development Committee Charter and
the Amended and Restated Research and Development Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

5

 

          “Development Services” has the meaning set forth in Section 1(b) of the RRD Services
Agreement.

          “Director(s)” has the meaning set forth in the Preliminary Statement of the Indemnification
Agreement.

          “Disclosing Party” has the meaning set forth in Section 3 of the Confidentiality Agreement.

          “Discontinuation Closing Date” has the meaning set forth in Section 11.3 of the Amended and
Restated Research and Development Agreement.

          “Discontinuation Date” means any date designated by Symphony Dynamo which shall occur on or
after the 90th day following the receipt by Dynavax of notice from Symphony Dynamo of
Symphony Dynamo’s intent to discontinue a Program in accordance with the terms of the Amended and
Restated Research and Development Agreement.

          “Discontinuation Option” has the meaning set forth in Section 11.3 of the Amended and Restated
Research and Development Agreement.

          “Discontinuation Price” has the meaning set forth in Section 11.3 of the Amended and Restated
Research and Development Agreement.

          “Discontinuation Price Dispute Notice” has the meaning set forth in Section 11.3(b) of the
Amended and Restated Research and Development Agreement.

          “Discontinued Program” has the meaning set forth in Section 2.11 of the Novated and Restated
Technology License Agreement.

          “Discontinuation Program Funding” has the meaning set forth in Section 11.3(b) of the Amended
and Restated Research and Development Agreement.

          “Disinterested Directors” has the meaning set forth in Article X of the Symphony Dynamo
Charter.

          “Distribution” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Dynavax” means Dynavax Technologies Corporation, a Delaware corporation.

          “Dynavax Common Stock” means the common stock, par value $0.001 per share, of Dynavax.

          “Dynavax Common Stock Valuation” has the meaning set forth in Section 2(e) of the Purchase
Option Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

6

 

          “Dynavax Obligations” has the meaning set forth in Section 6.1 of the Amended and Restated
Research and Development Agreement.

          “Dynavax Personnel” has the meaning set forth in Section 8.4 of the Amended and Restated
Research and Development Agreement.

          “Dynavax Subcontractor” has the meaning set forth in Section 6.2 of the Amended and Restated
Research and Development Agreement.

          “Early Purchase Option Exercise” has the meaning set forth in Section 1(c)(iv) of the Purchase
Option Agreement.

          “Effective Registration Date” has the meaning set forth in Section 1(b) of the Registration
Rights Agreement

          “Encumbrance” means (i) any security interest, pledge, mortgage, lien (statutory or other),
charge or option to purchase, lease or otherwise acquire any interest, (ii) any adverse claim,
restriction, covenant, title defect, hypothecation, assignment, deposit arrangement, license or
other encumbrance of any kind, preference or priority, or (iii) any other security agreement or
preferential arrangement of any kind or nature whatsoever (including, without limitation, any
conditional sale or other title retention agreement).

          “Enhancements” means findings, improvements, discoveries, inventions, additions,
modifications, enhancements, derivative works, clinical development data, or changes to the
Licensed Intellectual Property and/or Regulatory Files, in each case whether or not patentable.

          “Equity Securities” means, with respect to any Person, shares of capital stock of (or other
ownership or profit interests in) such Person, warrants, options or other rights for the purchase
or other acquisition from such Person of shares of capital stock of (or other ownership or profit
interests in) such Person, securities convertible into or exchangeable for shares of capital stock
of (or other ownership or profit interests in) such Person or warrants, rights or options for the
purchase or other acquisition from such Person of such shares (or such other interests), and other
ownership or profit interests in such Person (including, without limitation, partnership, member or
trust interests therein), whether voting or nonvoting, and whether or not such shares, warrants,
options, rights or other interests are authorized or otherwise existing on any date of
determination.

          “ERISA” means the United States Employee Retirement Income Security Act of 1974, as amended.

          “Excepted Debt” has the meaning set forth in Section 5(c)(iii) of the Purchase Option
Agreement.

          “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and
regulations promulgated thereunder.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

7

 

          “Excluded ISS” means [ * ].

          “Existing NDA” has the meaning set forth in Section 2 of the Confidentiality Agreement.

          “External Directors” has the meaning set forth in the preamble of the Confidentiality
Agreement.

          “FDA” means the United States Food and Drug Administration or its successor agency in the
United States.

          “FDA Sponsor” has the meaning set forth in Section 5.1 of the Amended and Restated Research
and Development Agreement.

          “Final Discontinuation Price” has the meaning set forth in Section 11.3(c) of the Amended and
Restated Research and Development Agreement.

          “Financial Audits” has the meaning set forth in Section 6.6 of the Amended and Restated
Research and Development Agreement.

          “Financing” has the meaning set forth in the Preliminary Statement of the Purchase Option
Agreement.

          “Fiscal Year” has the meaning set forth in each Operative Document in which it appears.

          “Form S-3” means the Registration Statement on Form S-3 as defined under the Securities Act.

          “FTE” has the meaning set forth in Section 4.1 of the Amended and Restated Research and
Development Agreement.

          “Funding Agreement” means the Funding Agreement, dated as of the Closing Date, among Dynavax,
SCP and Investors.

          “Funding Notice” has the meaning set forth in Section 2(b) of the Funding Agreement.

          “GAAP” means generally accepted accounting principles in effect in the United States of
America from time to time.

          “Governmental Approvals” means authorizations, consents, orders, declarations or approvals of,
or filings with, or terminations or expirations of waiting periods imposed by any Governmental
Authority.

          “Governmental Authority” means any United States or non-United States federal, national,
supranational, state, provincial, local, or similar government, governmental, regulatory

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

8

 

or administrative authority, agency or commission or any court, tribunal, or judicial or
arbitral body.

          “Governmental Order” means any order, writ, judgment, injunction, decree, stipulation,
determination or award entered by or with any Governmental Authority.

          “Hedge Agreement” means any interest rate swap, cap or collar agreement, interest rate future
or option contract, currency swap agreement, currency future or option contract or other similar
hedging agreement.

          “Hepatitis B Products” mean [ * ].

          “Hepatitis B Program” means the identification, development, manufacture and/or use of any
Hepatitis B Products in Accordance with the Development Plan.

          “Hepatitis C Products” mean [ * ].

          “Hepatitis C Program” means the identification, development, manufacture and/or use of any
Hepatitis C Products in Accordance with the Development Plan.

          “Holdings” means Symphony Dynamo Holdings LLC, a Delaware limited liability company.

          “Holdings Claims” has the meaning set forth in Section 5.01 of the Warrant Purchase Agreement.

          “Holdings LLC Agreement” means the Amended and Restated Limited Liability Company Agreement of
Holdings, dated as of the Closing Date.

          “HSR Act Filings” means the premerger notification and report forms required under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended.

          “IND” means an Investigational New Drug Application, as described in 21 U.S.C. § 355(i)(1) and
21 C.F.R. § 312 in the regulations promulgated by the United States Food and Drug Administration,
or any foreign equivalent thereof.

          “Indemnification Agreement” means the Indemnification Agreement among Symphony Dynamo and the
Directors named therein, dated as of the Closing Date.

          “Indemnified Party” has the meaning set forth in each Operative Document in which it appears.

          “Indemnified Proceeding” has the meaning set forth in each Operative Document in which it
appears.

          “Indemnifying Party” has the meaning set forth in each Operative Document in which it appears.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

9

 

          “Independent Accountant” has the meaning set forth in Section 11.3(c) of the Amended and
Restated Research and Development Agreement.

          “Initial Development Budget” means the initial development budget prepared by representatives
of Symphony Dynamo and Dynavax prior to the Closing Date, and attached to the Amended and Restated
Research and Development Agreement as Annex D thereto.

          “Initial Development Plan” means the initial development plan prepared by representatives of
Symphony Dynamo and Dynavax prior to the Closing Date, and attached to the Amended and Restated
Research and Development Agreement as Annex C thereto.

          “Initial Funds” has the meaning set forth in Section 2(a) of the Funding Agreement.

          “Initial Holdings LLC Agreement” means the Agreement of Limited Liability Company of Holdings,
dated January 10, 2006.

          “Initial Investors LLC Agreement” means the Agreement of Limited Liability Company of
Investors, dated January 10, 2006.

          “Initial LLC Member” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Interest Certificate” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

          Investment Company Act” means the Investment Company Act of 1940, as amended.

          “Investment Overview” means the investment overview describing the transactions entered into
pursuant to the Operative Documents.

          “Investment Policy” has the meaning set forth in Section 1(a)(vi) of the RRD Services
Agreement.

          “Investors” means Symphony Dynamo Investors LLC.

          “Investors LLC Agreement” means the Amended and Restated Agreement of Limited Liability
Company of Investors dated as of the Closing Date

          “IRS” means the U.S. Internal Revenue Service.

          “ISS” means any synthetic oligonucleotide sequence or chimeric oligonucleotide sequence that
modulates an immune response, including, but not limited to, such sequences referred to by Dynavax
as immunostimulatory sequences, chimeric immunomodulatory compounds and branched immunomodulatory
compounds.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

10

 

          “Knowledge” means the actual (and not imputed) knowledge of the executive officers of Dynavax,
without the duty of inquiry or investigation.

          “Law” means any law, statute, treaty, constitution, regulation, rule, ordinance, order or
Governmental Approval, or other governmental restriction, requirement or determination, of or by
any Governmental Authority.

          “License” has the meaning set forth in the Preliminary Statement of the Purchase Option
Agreement.

          “Licensed Intellectual Property” means the Licensed Patent Rights, Symphony  Dynamo
Enhancements, Licensor Enhancements and the Licensed Know-How.

          “Licensed Know-How” means [ * ].

          (a) “Licensed Patent Rights” means:[ * ].

          “Licensor” means Dynavax.

          “Licensor Enhancements” means [ * ].

          “Lien” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Liquidating Event” has the meaning set forth in Section 8.01 of the Holdings LLC Agreement.

          “LLC Agreements” means the Initial Holdings LLC Agreement, the Holdings LLC Agreement, the
Initial Investors LLC Agreement and the Investors LLC Agreement.

          “Loss” has the meaning set forth in each Operative Document in which it appears.

          “Management Budget Component” has the meaning set forth in Section 4.1 of the Amended and
Restated Research and Development Agreement.

          “Management Fee” has the meaning set forth in Section 6(a) of the RRD Services Agreement.

          “Manager” means (i) for each LLC Agreement in which it appears, the meaning set forth in such
LLC Agreement, and (ii) for each other Operative Document in which it appears, RRD.

          “Management Services” has the meaning set forth in Section 1(a) of the RRD Services Agreement.

          “Manager Event” has the meaning set forth in Section 3.01(g) of the Holdings LLC Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

11

 

          “Material Adverse Effect” means, with respect to any Person, a material adverse effect on (i)
the business, assets, property or condition (financial or otherwise) of such Person or, (ii) its
ability to comply with and satisfy its respective agreements and obligations under the Operative
Documents or, (iii) the enforceability of the obligations of such Person of any of the Operative
Documents to which it is a party.

          “Material Subsidiary” means, at any time, a Subsidiary of Dynavax having assets in an amount
equal to at least 5% of the amount of total consolidated assets of Dynavax and its Subsidiaries
(determined as of the last day of the most recent reported fiscal quarter of Dynavax) or revenues
or net income in an amount equal to at least 5% of the amount of total consolidated revenues or net
income of Dynavax and its Subsidiaries for the 12-month period ending on the last day of the most
recent reported fiscal quarter of Dynavax.

          “Medical Discontinuation Event” means [ * ].

          “Membership Interest” means (i) for each LLC Agreement in which it appears, the meaning set
forth in such LLC Agreement, and (ii) for each other Operative Document in which it appears, the
meaning set forth in the Holdings LLC Agreement.

          “NASDAQ” means the National Association of Securities Dealers Automated Quotation System.

          “NDA” means a New Drug Application, as defined in the regulations promulgated by the United
States Food and Drug Administration, or any foreign equivalent thereof.

          “Non-Dynavax Capital Transaction” means any (i) sale or other disposition of all or part of
the Symphony Dynamo Shares or all or substantially all of the operating assets of Symphony Dynamo,
to a Person other than Dynavax or an Affiliate of Dynavax or (ii) distribution in kind of the
Symphony Dynamo Shares following the expiration of the Purchase Option.

          “Non-Symphony Dynamo ISS” means [ * ].

          “Novated and Restated Technology License Agreement” means the Novated and Restated
Technology License Agreement, dated as of the Closing Date, among Dynavax, Symphony Dynamo and
Holdings.

          “Operative Documents” means, collectively, the Indemnification Agreement, the Holdings LLC
Agreement, the Purchase Option Agreement, the Warrant Purchase Agreement, the Registration Rights
Agreement, the Subscription Agreement, the Technology License Agreement, the Novated and Restated
Technology License Agreement, the RRD Services Agreement, the Research and Development Agreement,
the Amended and Restated Research and Development Agreement, the Confidentiality Agreement, the
Funding Agreement and each other certificate and agreement executed in connection with any of the
foregoing documents.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

12

 

          “Organizational Documents” means any certificates or articles of incorporation or formation,
partnership agreements, trust instruments, bylaws or other governing documents.

          “Partial Stock Payment” has the meaning set forth in Section 3(a)(iii) of the Purchase Option
Agreement.

          “Party(ies)” means, for each Operative Document or other agreement in which it appears, the
parties to such Operative Document or other agreement, as set forth therein. With respect to any
agreement in which a provision is included therein by reference to a provision in another
agreement, the term “Party” shall be read to refer to the parties to the document at hand, not the
agreement that is referenced.

          “Payment Terms” has the meaning set forth in Section 8.2 of the Amended and Restated Research
and Development Agreement.

          “Percentage” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Permitted Investments” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

          “Permitted Lien” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Person” means any individual, partnership (whether general or limited), limited liability
company, corporation, trust, estate, association, nominee or other entity.

          “Personnel” of a Party means such Party, its employees, subcontractors, consultants,
representatives and agents.

          “Prime Rate” means the quoted “Prime Rate” at JPMorgan Chase Bank or, if such bank ceases to
exist or is not quoting a base rate, prime rate reference rate or similar rate for United States
dollar loans, such other major money center commercial bank in New York City selected by the
Manager.

          “Products” means Cancer Products, Hepatitis B Products and Hepatitis C Products.

          “Profit” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “Program Option” has the meaning set forth in Section 11.1(a) of the Amended and Restated
Research and Development Agreement.

          “Program Option Closing Date” has the meaning set forth in Section 11.1(b) of the Amended and
Restated Research and Development Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

13

 

          “Program Option Exercise Date” has the meaning set forth in Section 11.1(b) of the Amended and
Restated Research and Development Agreement.

          “Program Option Exercise Notice” has the meaning set forth in Section 11.1(b) of the Amended
and Restated Research and Development Agreement.

          “Program Option Period” has the meaning set forth in Section 11.1(a) of the Amended and
Restated Research and Development Agreement.

          “Programs” means Cancer Program, Hepatitis B Program and Hepatitis C Program.

          “Protocol” means a written protocol that meets the substantive requirements of Section 6 of
the ICH Guideline for Good Clinical Practice as adopted by the FDA, effective May 9, 1997 and is
included within the Development Plan or later modified or added to the Development Plan pursuant to
the Amended and Restated Research and Development Agreement.

          “Public Companies” has the meaning set forth in Section 5(e) of the Purchase Option Agreement.

          “Purchase Option” has the meaning set forth in Section 1(a) of the Purchase Option Agreement.

          “Purchase Option Agreement” means this Purchase Option Agreement dated as of the Closing Date,
among Dynavax, Holdings and Symphony Dynamo.

          “Purchase Option Closing” has the meaning set forth in Section 2(a) of the Purchase Option
Agreement.

          “Purchase Option Closing Date” has the meaning set forth in Section 2(a) of the Purchase
Option Agreement.

          “Purchase Option Commencement Date” has the meaning set forth in Section 1(c)(iii) of the
Purchase Option Agreement.

          “Purchase Option Exercise Date” has the meaning set forth in Section 2(a) of the Purchase
Option Agreement.

          “Purchase Option Exercise Notice” has the meaning set forth in Section 2(a) of the Purchase
Option Agreement.

          “Purchase Option Interim Date” has the meaning set forth in Section 2(b)(i) of the Purchase
Option Agreement.

          “Purchase Option Period” has the meaning set forth in Section 1(c)(iii) of the Purchase Option
Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

14

 

          “Purchase Price” has the meaning set forth in Section 2(b) of the Purchase Option Agreement.

          “Put Option” has the meaning set forth in Section 2A of the Purchase Option Agreement.

          “Put Option Exercise Notice” has the meaning set forth in Section 2A of the Purchase Option
Agreement.

          “QA Audits” has the meaning set forth in Section 6.5 of the Amended and Restated Research and
Development Agreement.

          “Quarterly Price” has the meaning set forth in Section 2(b)(i) of the Purchase Option
Agreement.

          “Regents” has the meaning set forth in Section 3.1 of the Novated and Restated Technology
License Agreement.

          “Regents Agreement” has the meaning set forth in Section 3.1 of the Novated and Restated
Technology License Agreement.

          “Registration Rights Agreement” means the Registration Rights Agreement dated as of the
Closing Date, between Dynavax and Holdings.

          “Registration Statement” has the meaning set forth in Section 1(b) of the Registration Rights
Agreement.

          “Regulatory Authority” means the United States Food and Drug Administration, or any successor
agency in the United States, or any health regulatory authority(ies) in any other country that is a
counterpart to the FDA and has responsibility for granting registrations or other regulatory
approval for the marketing, manufacture, storage, sale or use of drugs in such other country.

          “Regulatory Allocation” has the meaning set forth in Section 3.06 of the Holdings LLC
Agreement.

          “Regulatory Files” means any IND, NDA or any other filings filed with any Regulatory Authority
with respect to the Programs.

          “Related Oncology Products Agreement” has the meaning set forth in Section 11.4 of the Amended
and Restated Research and Development Agreement.

          “Replacement Warrant(s)” has the meaning set forth in Section 7.08 of the Warrant Purchase
Agreement.

          “Representative” of any Person means such Person’s shareholders, principals, directors,
officers, employees, members, managers and/or partners.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

15

 

          “Research and Development Agreement” means the Research and Development Agreement dated as of
the Closing Date, between Dynavax and Holdings.

     “Rhein” has the meaning set forth in Section 11.1(a) of the Amended and Restated Research and
Development Agreement.

     “Rhein Sale Agreement” has the meaning set forth in Section 11.2(a) of the Amended and
Restated Research and Development Agreement.

          “RRD” means RRD International, LLC, a Delaware limited liability company.

          “RRD Indemnified Party” has the meaning set forth in Section 10(a) of the RRD Services
Agreement.

          “RRD Loss” has the meaning set forth in Section 10(a) of the RRD Services Agreement.

          “RRD Parties” has the meaning set forth in Section 9(e) of the RRD Services Agreement.

          “RRD Personnel” has the meaning set forth in Section 1(a)(ii) of the RRD Services Agreement.

          “RRD Services Agreement” means the RRD Services Agreement between Symphony Dynamo and RRD,
dated as the Closing Date, 2006.

          “Schedule K-1” has the meaning set forth in Section 9.02(a) of the Holdings LLC Agreement.

          “Scheduled Meeting” has the meaning set forth in Paragraph 6 of Annex B of the Amended and
Restated Research and Development Agreement.

          “Scientific Discontinuation Event” has the meaning set forth in Section 4.2(c) of the Amended
and Restated Research and Development Agreement.

          “SCP” means Symphony Capital Partners, L.P., a Delaware limited partnership.

          “SD Program Option” has the meaning set forth in Section 11.2(b) of the Amended and Restated
Research and Development Agreement.

          “SD Program Option Exercise Notice” has the meaning set forth in Section 11.2(b) of the
Amended and Restated Research and Development Agreement.

          “SEC” means the United States Securities and Exchange Commission.

          “Securities Act” means the Securities Act of 1933, as amended.

          “Selected ISS” means [ * ].

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

16

 

          “Shareholder” means any Person who owns any Symphony Dynamo Shares.

          “Solvent” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

          “SSP” means Symphony Strategic Partners, LLC, a Delaware limited liability company.

          “Stock Payment Date” has the meaning set forth in Section 2 of the Subscription Agreement.

          “Stock Purchase Price” has the meaning set forth in Section 2 of the Subscription Agreement.

          “Subcontracting Agreement” has the meaning set forth in Section 6.2 of the Amended and
Restated Research and Development Agreement.

          “Subscription Agreement” means the Subscription Agreement between Symphony Dynamo and
Holdings, dated as the Closing Date.

          “Subsidiary” of any Person means any corporation, partnership, joint venture, limited
liability company, trust or estate of which (or in which) more than 50% of (a) the issued and
outstanding capital stock having ordinary voting power to elect a majority of the board of
directors of such corporation (irrespective of whether at the time capital stock of any other class
or classes of such corporation shall or might have voting power upon the occurrence of any
contingency); (b) the interest in the capital or profits of such partnership, joint venture or
limited liability company; or (c) the beneficial interest in such trust or estate is at the time
directly or indirectly owned or controlled by such Person, by such Person and one or more of its
other Subsidiaries or by one or more of such Person’s other Subsidiaries.

          “Surviving Entity” means the surviving or resulting “parent” legal entity which is surviving
entity to Dynavax after giving effect to a Change of Control.

          “Symphony Capital” means Symphony Capital LLC, a Delaware limited liability company.

          “Symphony Dynamo” means Symphony Dynamo, Inc., a Delaware corporation.

          “Symphony Dynamo Auditors” has the meaning set forth in Section 5(b) of the RRD Services
Agreement.

          “Symphony Dynamo Board” means the board of directors of Symphony Dynamo.

          “Symphony Dynamo By-laws” means the By-laws of Symphony Dynamo, as adopted by resolution of
the Symphony Dynamo Board on the Closing Date.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

17

 

          “Symphony Dynamo Charter” means the Amended and Restated Certificate of Incorporation of
Symphony Dynamo, dated as of the Closing Date.

          “Symphony Dynamo Director Event” has the meaning set forth in Section 3.01(h)(i) of the
Holdings LLC Agreement.

          “Symphony Dynamo Enhancements” means [ * ].

          “Symphony Dynamo Equity Securities” means the Common Stock and any other stock or shares
issued by Symphony Dynamo.

          “Symphony Dynamo Loss” has the meaning set forth in Section 10(b) of the RRD Services
Agreement.

          “Symphony Dynamo Shares” has the meaning set forth in Section 2.02 of the Holdings LLC
Agreement.

          “Symphony Fund(s)” means Symphony Capital Partners, L.P., a Delaware limited partnership, and
Symphony Strategic Partners, LLC, a Delaware limited liability company.

          “Tangible Materials” means [ * ].

          “Tax Amount” has the meaning set forth in Section 4.02 of the Holdings LLC Agreement.

          “Technology License Agreement” means the Technology License Agreement, dated as of the Closing
Date, between Dynavax and Holdings.

          “Term” has the meaning set forth in Section 4(b)(iii) of the Purchase Option Agreement, unless
otherwise stated in any Operative Document.

          “Territory” means the world.

          “Third Party IP” has the meaning set forth in Section 2.11 of the Novated and Restated
Technology License Agreement.

          “Third Party Licensor” means a third party from which Dynavax has received a license or
sublicense to Licensed Intellectual Property.

          “Transfer” has for each Operative Document in which it appears the meaning set forth in such
Operative Document.

          “Transferee” has, for each Operative Document in which it appears, the meaning set forth in
such Operative Document.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

18

 

          “Voluntary Bankruptcy” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

          “Warrant(s)” means the “Warrant” as defined in Section 2.01 of the Warrant Purchase Agreement,
and/or any successor certificates exercisable for Warrant Shares issued by Dynavax.

          “Warrant Closing” has the meaning set forth in Section 2.03 of the Warrant Purchase Agreement.

          “Warrant Date” has the meaning set forth in Section 2.02 of the Warrant Purchase Agreement.

          “Warrant Purchase Agreement” means the Warrant Purchase Agreement, dated as of the Closing
Date, between Dynavax and Holdings.

          “Warrant Shares” has the meaning set forth in Section 2.01 of the Warrant Purchase Agreement.

          “Warrant Surrender Price” has the meaning set forth in Section 7.08 of the Warrant Purchase
Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex A to the

Amended and Restated R&D Agreement

19

 

ANNEX B

SYMPHONY DYNAMO, INC.

DEVELOPMENT COMMITTEE CHARTER

Purpose

          The Development Committee (the “Development Committee”) is established by Symphony Dynamo,
Inc. (“Symphony Dynamo”) and Dynavax Technologies Corporation (“Dynavax”, and together with
Symphony Dynamo, the “Parties” and each a “Party”) to oversee a clinical development plan (the
“Development Plan”) and a development budget (the “Development Budget”) for the Programs (each as
defined in that certain Novated and Restated Technology License Agreement (“TLA”), dated as of
April 18, 2006, among Symphony Dynamo, Dynavax, and Symphony Dynamo Holdings LLC (“Holdings”)), and
to develop and commercialize the Cancer Products, the Hepatitis B Products and the Hepatitis C
Products (each as defined in the TLA). Capitalized terms used herein and not defined herein shall
have the meanings assigned to such terms in Annex A to the Amended and Restated Research and
Development Agreement, dated as of April 18, 2006, among Symphony Dynamo, Holdings and Dynavax.

Composition

	 	1.	 	The Development Committee shall initially have six (6) members, and at all
times shall have an even number of members and consist of an equal number of members
designated by each Party (the “Development Committee Members”). Each Party may bring
additional employees or representatives to each meeting as non-voting observers, but
only if such employees or representatives are bound by confidentiality obligations at
least as stringent as those described in the Confidentiality Agreement. The size and
composition of the Development Committee provided herein may not be changed without the
consent of both the Symphony Dynamo Board and Dynavax.
	 
	 	2.	 	One-half (1/2) of the Development Committee Members shall be designated by
Dynavax and one-half (1/2) shall be designated by the Symphony Dynamo Board.
	 
	 	3.	 	Each Development Committee Member shall have the requisite background,
experience and training to carry out the duties and obligations of the Development
Committee. Development Committee Members need not be directors of Symphony Dynamo or
Dynavax.
	 
	 	4.	 	The chair of the Development Committee shall be, initially, Eduardo Martins,
M.D., Vice President, Clinical Development, of Dynavax, and any succeeding chair shall
be such person as may be appointed to the position of either Chief Medical Officer or
Vice President, Clinical Development of Dynavax (or an equivalent successor position)
(the “Chair”). If Dynavax wishes to appoint a

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex B to the

Amended and Restated R&D Agreement

1

 

	 	 	 	Chair other than either the then-current Chief Medical Officer or Vice President,
Clinical Development, of Dynavax (or the holder of an equivalent successor
position), then such appointment shall require the consent of the Symphony Dynamo
Board; provided, that (x) [ * ], or (y) [ * ].
	 
	 	5.	 	The Development Committee Members may be removed or replaced by the Symphony
Dynamo Board, solely with respect to the removal or replacement of any such Development
Committee Members selected by Symphony Dynamo, and by Dynavax, solely with respect to
the removal or replacement of any such Development Committee Members selected by
Dynavax.

Operations

	 	6.	 	The Development Committee shall meet once per month during the Term, unless and
until the Development Committee determines that such meetings should occur once per
quarter (in either case, each a “Scheduled Meeting”). Scheduled Meetings may be held
in person or by teleconference when appropriate. Each of Symphony Dynamo and Dynavax
shall be solely responsible for the costs associated with its employees and/or
representatives attending and participating in such Scheduled Meetings. In addition,
the Chair and any Development Committee Member selected by Symphony Dynamo may jointly
call for an ad hoc meeting of the Development Committee by teleconference at any time,
by giving the other members of the Development Committee advance written notice of at
least [ * ] (each, an “Ad Hoc Meeting”). An Ad Hoc Meeting may be called to address
any time-sensitive matter, including additional expenditure requests pursuant to
Section 8.3 of the Amended and Restated Research and Development Agreement or Section 2
of the RRD Services Agreement.
	 
	 	7.	 	The Chair shall, in consultation with other Development Committee Members and
the management of Symphony Dynamo, develop and set the Development Committee’s agenda
for each Scheduled Meeting. The Chair shall include on such agenda each item requested
by a Development Committee member at least [ * ] before the applicable Scheduled
Meeting. The agenda and information concerning the business to be conducted at each
Scheduled Meeting shall be communicated in writing to the Development Committee Members
at least [ * ] in advance of such Scheduled Meeting to permit meaningful review. Such
an agenda shall not be required for an Ad Hoc Meeting.
	 
	 	8.	 	Each Party’s Development Committee Members shall collectively have three (3)
votes, regardless of the number of its Development Committee Members participating in
any Scheduled Meeting or Ad Hoc Meeting. No votes shall be taken unless there is at
least one (1) Development Committee Member representing each of Dynavax and Symphony
Dynamo participating in such Scheduled Meeting or Ad Hoc Meeting, as the case may be.
Each Party may allocate its three (3) votes among its attending Development Committee
Members

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex B to the

Amended and Restated R&D Agreement

2

 

	 	 	 	in any manner, at such Party’s discretion. If only one (1) Development Committee
Member is attending on behalf of a given Party, such Development Committee Member
may cast all the votes allocated to such Party. Unless otherwise specified herein,
all actions taken by the Development Committee as a committee shall be by majority
vote. If the Development Committee Members reach a deadlock on any vote, then such
deadlock shall be resolved in accordance with Paragraph 11 of this
Development Committee Charter.
	 
	 	9.	 	Notwithstanding anything herein to the contrary, during the Term, this
Development Committee Charter may be amended only with the unanimous approval of the
Development Committee Members and the consent of the Symphony Dynamo Board.
	 
	 	10.	 	The Chair, or such person as the Chair may designate, shall prepare, and
distribute to all Development Committee Members, draft committee minutes within a
reasonable period of time following each Scheduled Meeting or Ad Hoc Meeting.
	 
	 	11.	 	If the Development Committee is unable to decide by a majority vote on any
issue within the scope of its authority and duties, then the Development Committee
shall promptly raise such issue to the chief executive officers (or equivalent officer)
of Dynavax and Symphony Dynamo. The chief executive officers shall have [ * ] days to
mutually agree on how to resolve such issue. If the Parties’ chief executive officers
are unable to resolve such issue within the [ * ] day period, then [ * ].

Authority and Duties

	 	12.	 	The Development Committee shall, using the Initial Development Plan and the
Initial Development Budget as a basis, continue to develop and refine the Development
Plan and Development Budget, and shall, at the request of the Symphony Dynamo Board,
submit each for review by the Symphony Dynamo Board at the first meeting of the
Symphony Dynamo Board, as provided in Section 4.1 of the Amended and Restated Research
and Development Agreement. Following the Symphony Dynamo Board’s review, the
Development Committee shall work diligently to incorporate the comments generated by
such review in order to complete the Development Plan and Development Budget as soon as
practicable and, upon completion, shall then submit the Development Plan and the
Development Budget to the Symphony Dynamo Board for approval. The Development
Committee shall thereafter continue to develop and refine the Development Plan and the
Development Budget, and shall conduct a comprehensive review of each on an annual
basis. In addition, the Development Committee shall decide on any other matters
relating to the Development Plan and the Development Budget that may arise, including
(i) responding to requests for amendments to the Development Plan and/or the
Development Budget from RRD or Dynavax, (ii) the selection of ISSs that have TLR-9
activity for inclusion

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex B to the

Amended and Restated R&D Agreement

3

 

	 	 	 	in the Development Plan, (iii) within [ * ] of the Development Committee becoming
aware that the Purchase Option will or has expired unexercised, or will or has been
terminated, the Development Committee shall, for each ISS previously selected as a
Selected ISS for inclusion in any Development Plan, select [ * ] additional ISSs
that have TLR-9 activity (other than Non-Symphony Dynamo ISSs) as backup ISSs to
also be deemed Selected ISSs, and (iv) addressing all other matters that are
identified in the Operative Documents or the Symphony Dynamo Charter as requiring
the approval of the Development Committee (including, but not limited to, the
approval of any new, or the amendment or termination of any existing, Subcontracting
Agreement). Unless otherwise approved pursuant to Paragraph 11 hereof, or
discontinued or modified pursuant to Sections 4.2(c) or 5.1 of the Amended and
Restated Research and Development Agreement, no material change to the Development
Plan or Development Budget will be adopted by Symphony Dynamo unless and until the
Development Committee approves such change.
	 
	 	13.	 	The Development Committee shall report at least quarterly to the Symphony
Dynamo Board regarding progress relative to the Development Plan and the Development
Budget, and any changes in the Development Plan and/or Development Budget, and shall
respond promptly to any reasonable requests for additional information made by the
Symphony Dynamo Board. The Development Committee shall also submit its material
decisions regarding the Development Plan and Development Budget to the Symphony Dynamo
Board, including regulatory strategies and discontinuation or modification of the
Programs.
	 
	 	14.	 	The Development Committee shall continuously evaluate the funding requirements
of the Programs, and shall recommend to the Symphony Dynamo Board an appropriate date
to request that Holdings submit to Investors a Funding Notice with respect to a request
for the Additional Funds, and that Holdings make an additional capital contribution to
Symphony Dynamo from the funds Holdings receives from Investors pursuant thereto.

          The foregoing list of duties is not exhaustive, and the Development Committee may, in
addition, perform such other functions as may be necessary or appropriate for the performance of
its duties and the furtherance of the development of Programs, including as may be required under
any Operative Document. In no event shall the Development Committee have the power to amend any of
the Operative Documents. The Development Committee shall have the power to delegate its authority
and duties to sub-committees as it deems appropriate; provided, however, that any
such sub-committee shall have at least one (1) Development Committee Member who is appointed to the
Development Committee by the Symphony Dynamo Board and at least one Development Committee Member
who is appointed by Dynavax.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO
RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex B to the

Amended and Restated R&D Agreement

4

 

ANNEX C

INITIAL DEVELOPMENT PLAN

[ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED
SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex C to the

Amended and Restated R&D Agreement

 

 

ANNEX D

INITIAL DEVELOPMENT BUDGET

[ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED
SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.

Annex D to the

Amended and Restated R&D Agreement

 

 

ANNEX E

PAYMENT TERMS

	1.	 	[ * ]
	 
	2.	 	[ * ]
	 
	3.	 	[ * ]
	 
	4.	 	Invoices must be submitted by Dynavax to Symphony Dynamo by the [ * ] day of each month.
Invoices not received by Symphony Dynamo on the required date may result in delays in payment
to Dynavax.
	 
	5.	 	Prior to any payments being made to Dynavax, Dynavax agrees to complete a W-9 form and supply
Dynavax’s social security or TIN number to Symphony Dynamo, as appropriate, or supply a
written declaration of foreign resident status and ineligibility for U.S. withholding taxes.
Dynavax is responsible for maintaining adequate records for tax purposes. If Dynavax requests
summaries or break-downs of compensation in addition to the 1099 form or analogous form that
Symphony Dynamo provides, Symphony Dynamo will charge Dynavax a fee for preparing the
requested documents, based on the amount of time expended by Symphony Dynamo.
	 
	6.	 	Symphony Dynamo shall pay each invoice within [ * ] days of receipt. All fees will be
payable in US Dollars. If Symphony Dynamo disputes in good faith any portion of an invoice,
then Symphony Dynamo shall pay the undisputed amounts as set forth in the preceding sentence
and the Parties shall use good faith efforts to reconcile the
disputed amount as soon as
practicable.
	 
	7.	 	Dynavax will mail invoices to Symphony Dynamo at the following address:

Symphony Dynamo, Inc.

7361 Calhoun Place, Suite 325

Rockville, MD 20855

Attn: Accounts Payable

	8.	 	All payments to Dynavax shall be sent to Dynavax by wire transfer to the following account:

Account:                     

Bank:                     

                              

ABA Routing:                     

Account number:                     

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS
BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE
24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.exv10w29

 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Exhibit 10.29

EXECUTION COPY

 

NOVATED AND RESTATED

TECHNOLOGY LICENSE AGREEMENT

dated as of April 18, 2006

among

DYNAVAX TECHNOLOGIES CORPORATION,

SYMPHONY DYNAMO, INC.

and

SYMPHONY DYNAMO HOLDINGS LLC

 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

 

 

Table of Contents

	 	 	 	 	 	 	 
	 	 	 	 	Page
	Article 1
	 	Definitions	 	 	1	 
	Article 2
	 	Grant Of Rights	 	 	1	 
	2.1.
	 	Assignment	 	 	1	 
	2.2.
	 	License Grant	 	 	2	 
	2.3.
	 	Sublicense to Licensor	 	 	2	 
	2.4.
	 	Right to Sublicense	 	 	2	 
	2.5.
	 	Partial Reversion of License upon
Licensor’s Exercise of Program Option or Discontinuation Option	 	 	3	 
	2.6.
	 	Reservation of Rights	 	 	3	 
	2.7.
	 	Regulatory Files After Expiration or Termination of Term	 	 	3	 
	2.8.
	 	Delivery of Materials After Expiration or Termination of Term	 	 	4	 
	2.9.
	 	Additional Covenants	 	 	4	 
	2.10.
	 	License Opportunities	 	 	4	 
	2.11.
	 	Separate Third Party License for Discontinued Program	 	 	5	 
	2.12.
	 	Supply of Materials After Expiration or Termination of Term	 	 	5	 
	Article 3
	 	Sublicense To Certain Third Party Intellectual Property	 	 	5	 
	3.1.
	 	General	 	 	5	 
	3.2.
	 	Licensor’s Covenant	 	 	5	 
	3.3.
	 	Sublicense Terms	 	 	5	 
	Article 4
	 	Intellectual Property	 	 	6	 
	4.1.
	 	Ownership	 	 	6	 
	4.2.
	 	Marking	 	 	6	 
	4.3.
	 	Prosecution and Maintenance	 	 	6	 
	4.4.
	 	Abandonment	 	 	7	 
	4.5.
	 	Infringement	 	 	7	 
	4.6.
	 	Enforcement Right During Term	 	 	7	 
	4.7.
	 	Post-Term Enforcement	 	 	8	 
	4.8.
	 	Withdrawal of Enforcement	 	 	9	 
	4.9.
	 	Recoveries	 	 	9	 
	4.10.
	 	Enforcement For Other Activities	 	 	10	 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

i

 

	 	 	 	 	 	 	 
	 	 	 	 	Page
	Article 5
	 	Representations And Warranties	 	 	10	 
	5.1.
	 	Representations and Warranties of Licensor	 	 	10	 
	5.2.
	 	Disclaimer and Acknowledgement	 	 	10	 
	Article 6
	 	Indemnification And Limitation Of Liability	 	 	11	 
	6.1.
	 	Indemnity	 	 	11	 
	6.2.
	 	Notice of Claims	 	 	12	 
	6.3.
	 	Defense of Proceedings	 	 	12	 
	6.4.
	 	Settlement	 	 	13	 
	6.5.
	 	Limitation of Liability	 	 	14	 
	6.6.
	 	Insurance	 	 	14	 
	Article 7
	 	Term And Termination	 	 	14	 
	7.1.
	 	Term	 	 	14	 
	7.2.
	 	Termination	 	 	14	 
	7.3.
	 	Survival	 	 	15	 
	7.4.
	 	Bankruptcy	 	 	15	 
	Article 8
	 	Miscellaneous	 	 	15	 
	8.1.
	 	Notices	 	 	15	 
	8.2.
	 	Entire Agreement	 	 	16	 
	8.3.
	 	Assignment	 	 	16	 
	8.4.
	 	Headings	 	 	17	 
	8.5.
	 	Independent Contractor	 	 	17	 
	8.6.
	 	Severability	 	 	17	 
	8.7.
	 	No Third-Party Beneficiaries	 	 	17	 
	8.8.
	 	Compliance with Laws	 	 	17	 
	8.9.
	 	Amendment	 	 	17	 
	8.10.
	 	Governing Law; Consent to Jurisdiction and Service of Process	 	 	17	 
	8.11.
	 	WAIVER OF JURY TRIAL	 	 	18	 
	8.12.
	 	Counterparts	 	 	18	 
	8.13.
	 	No Waiver	 	 	18	 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

ii

 

	 	 	 
	Annex A

	 	Definitions
	Annex B

	 	Patents Covering Licensed Patent Rights
	Annex C

	 	Sublicense Terms

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

iii

 

NOVATED AND RESTATED

TECHNOLOGY LICENSE AGREEMENT

     This NOVATED AND RESTATED TECHNOLOGY LICENSE AGREEMENT (this “Agreement”) is made and
effective as of April 18, 2006 by and among, Dynavax Technologies Corporation, a Delaware
corporation (the “Licensor”), Symphony Dynamo, Inc., a Delaware corporation (“Symphony Dynamo”)
(each of Licensor and Symphony Dynamo, Inc. being a “Party,” and collectively, the “Parties”), and
Symphony Dynamo Holdings LLC, a Delaware limited liability company (“Holdings”).

     WHEREAS, Licensor and Holdings have entered into that certain Technology License Agreement,
dated April 18, 2006 (the “Original Agreement”);

     WHEREAS, Holdings desires to assign its right, title and interest in, and delegate and novate
its obligations under the Original Agreement to Symphony Dynamo, and Licensor and Symphony Dynamo
desire to novate and restate the terms and conditions of the Original Agreement to effect such
novation;

     WHEREAS, Licensor owns or has rights in certain technology, know-how, patents and other
intellectual property rights related to the design, development, manufacture and/or use of ISSs
and/or the Products;

     WHEREAS, Licensor desires to grant to Symphony Dynamo, and Symphony Dynamo desires to acquire,
the exclusive right to use such technology, know-how, patents and other intellectual property
rights to develop and commercialize Products on the terms and conditions of this Agreement; and

     WHEREAS, Licensor desires to receive, and Symphony Dynamo desires to grant to Licensor, the
exclusive right to use such technology, know-how, patents and other intellectual property rights to
develop Products on behalf of Symphony Dynamo on the terms and conditions of this Agreement.

     NOW THEREFORE, in consideration of the mutual promises and agreements set forth herein, and
for other good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the Parties agree as follows:

ARTICLE 1

DEFINITIONS

          Capitalized terms used herein and not defined shall have the meanings assigned to such terms
in Annex A attached hereto.

ARTICLE 2

GRANT OF RIGHTS

          2.1. Assignment. Holdings hereby assigns to Symphony Dynamo all of its right, title and interest in and to
the Original Agreement. The Parties agree that from and after the Closing Date, all of the right,
title, interest and obligations of Holdings under the Original

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

1

 

Agreement will be assigned, novated
and transferred to, and assumed by, Symphony Dynamo, as amended and restated by this Agreement.

          2.2. License Grant. Subject to Sections 2.3, 2.4 and 2.6
below, Licensor hereby grants to Symphony Dynamo, subject to the terms and conditions of this
Agreement, a fully paid, worldwide, exclusive (even as to Licensor) license under the Licensed
Intellectual Property, to develop, make, have made, use, offer for sale, sell, and import Products.

          2.3. Sublicense to Licensor. Symphony Dynamo hereby grants to Licensor a fully paid,
worldwide, exclusive (even as to Symphony Dynamo) sublicense under the Licensed Intellectual
Property, with the right to grant further sublicense(s), to develop, make, have made, use and
import Products, or otherwise as necessary or useful to carry out Licensor’s obligations or
exercise Licensor’s rights under the Operative Documents. Notwithstanding the foregoing, Licensor
shall only exercise its sublicense rights in connection with and for the purpose of carrying out
Licensor’s obligations or exercising Licensor’s rights under the Operative Documents. In the event
of the expiration of a Discontinuation Option without exercise by Licensor, the sublicense set
forth in this Section 2.3 shall expire with respect to the Products relating to the Program
to which such Discontinuation Option pertained. Upon the unexercised expiration or termination of
the Purchase Option without Licensor’s exercise of the Purchase Option, the sublicense set forth in
this Section 2.3 shall expire with respect to all Products relating to the Program(s) for
which Licensor has not exercised the Program Option or Discontinuation Option.

          2.4. Right to Sublicense. The license granted hereunder includes the right of
Symphony Dynamo to grant sublicenses under the Licensed Intellectual Property, provided, that,

          (a) subject to Sections 2.3 and 2.4(b), Symphony Dynamo shall not sublicense
any of the rights granted pursuant to Section 2.2 to any third party (including without
limitation any Affiliates) during the Term;

          (b) notwithstanding (a), in the event of the expiration of a Discontinuation Option without
exercise by Licensor, Symphony Dynamo may grant sublicense(s) to third parties (including without
limitation Affiliates) of the rights granted pursuant to Section 2.2 with respect to the
Products relating to the Program to which such Discontinuation Option pertained;

          (c) each sublicense granted is (i) pursuant to a written contract, (ii) consistent with the
terms of this Agreement, (iii) does not grant any rights beyond the scope of the license rights
granted herein, and (iv) is as protective of Licensor’s rights as set forth in this Agreement; and

          (d) upon Licensor’s written request, Symphony Dynamo shall provide to Licensor copies of any
sublicense agreements, provided that (i) Symphony Dynamo may redact any financial or other
proprietary information contained therein which does not affect Licensor’s rights and (ii) Licensor
shall treat its copy of the sublicense agreements as Confidential Information of Symphony Dynamo.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

2

 

          2.5. Partial Reversion of License upon Licensor’s Exercise of Program Option or
Discontinuation Option. Licensor and Symphony Dynamo acknowledge that Licensor may exercise
its Program Option pursuant to Section 11.1 of the Amended and Restated Research and Development
Agreement, or its Discontinuation Option pursuant to Section 11.3 of the Amended and Restated
Research and Development Agreement. Upon the Program Option Closing Date or the Discontinuation
Option Closing Date, as applicable, (i) the license set forth in Section 2.2 (and the
corresponding sublicense under Section 2.3) shall expire with respect to the Products
relating to the Program for which Licensor exercised its Program Option or Discontinuation Option,
as applicable; (ii) the Licensed Intellectual Property that relates exclusively to such Program
(including its Products) but not to the other Programs, shall be deleted from the relevant
intellectual property definitions, and accordingly, Symphony Dynamo shall no longer be responsible
for any obligations or costs (including royalties or fees to third parties, prosecution costs,
maintenance costs and enforcement costs) with respect to such deleted intellectual property; and
(iii) Symphony Dynamo shall (a) at Licensor’s request and option, promptly return to Licensor or
destroy all Tangible Materials relating solely to such Program; and (b) upon Licensor’s request,
provide Licensor a copy of any Tangible Materials which relate to such Program (but not solely to
such Program). The Parties shall, as necessary, promptly amend this Agreement, in connection with
the exercise and consummation of the Program Option pursuant to Section 11.1 or the Discontinuation
Option pursuant to Section 11.3 of the Amended and Restated Research and Development Agreement, (y)
to give Licensor all rights it needs to pursue the Program for which such option was exercised
without any obligation to or dependency on Symphony Dynamo and (z) to limit this Agreement to the
other Programs.

          2.6. Reservation of Rights. All rights not expressly granted to a Party hereunder
shall remain the exclusive property of the other Party. Symphony Dynamo covenants and agrees not
to use or exploit the Licensed Intellectual Property outside of the scope of the licenses granted
herein. Licensor covenants and agrees not to use or exploit the Licensed Intellectual Property in
connection with the development, manufacture, use, sale, or importation of Products after the
expiration of all sublicenses granted pursuant to Section 2.3; provided, however, that such
covenant by Licensor shall not apply to any Program for which Licensor exercises a Program Option
or Discontinuation Option or to any Products relating to such Program.

          2.7. Regulatory Files After Expiration or Termination of Term.

          (a) As soon as reasonably practicable after the expiration or termination of the Purchase
Option without exercise by Licensor and as of a date to be agreed upon by Licensor and Symphony
Dynamo, Licensor and Symphony Dynamo shall, at Symphony Dynamo’s expense, take all actions
necessary to effect the assignment to Symphony Dynamo or its designee of the sponsorship to the
Regulatory Files with respect to the Programs for which Licensor has not exercised its Program
Option or Discontinuation Option. After such Regulatory Files are assigned to Symphony Dynamo,
Licensor shall have no further rights therein or obligations thereunder; provided, however, that
during the [ * ] days following such assignment of Regulatory Files, at Symphony Dynamo’s
reasonable request and expense, Licensor shall use commercially reasonable efforts to provide
Symphony Dynamo or its designee with assistance in respect of such Regulatory Files. Licensor
shall, at the reasonable request of Symphony Dynamo

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

3

 

and at Symphony Dynamo’s expense, perform any
acts that Symphony Dynamo may reasonably deem necessary or desirable to evidence or confirm
Symphony Dynamo’s ownership interest in such Regulatory Files, including, but not limited to,
making further written assignments in a form determined by Symphony Dynamo. Without limiting the
license rights granted under this ARTICLE 2, the Parties understand and agree that the assignment
of such Regulatory Files does not include an assignment of any Licensed Intellectual Property.

          (b) In the event of the expiration of a Discontinuation Option without exercise by Licensor,
the provisions of Section 2.7(a) shall apply solely with respect to the Regulatory Files
for the Program to which the Discontinuation Option pertained.

          2.8. Delivery of Materials After Expiration or Termination of Term.

          (a) Upon the unexercised expiration or termination of the Purchase Option without exercise by
Licensor, Licensor shall, at Symphony Dynamo’s expense, promptly deliver to Symphony Dynamo all
copies of Tangible Materials existing as of the date of such unexercised expiration or termination
that relate to the Programs for which Licensor has not exercised its Program Option or
Discontinuation Option; provided, however that Licensor may also retain copies of (and the right to
use) those Tangible Materials that are required to be delivered to Symphony Dynamo hereunder but
which also relate to (i) any Program for which Licensor has exercised its Program Option or
Discontinuation Option or (ii) any other product of Licensor.

          (b) In the event of the expiration of a Discontinuation Option without exercise by Licensor,
Licensor shall, at Symphony Dynamo’s expense, promptly deliver to Symphony Dynamo all copies of
Tangible Materials existing as of the date of such expiration that relate to the Program to which
the Discontinuation Option pertained; provided, however that Licensor may also retain copies of
(and the right to use) those Tangible Materials that are required to be delivered to Symphony
Dynamo hereunder but which also relate to any other Program or any other product of Licensor.

          2.9. Additional Covenants. [ * ]

          2.10. License Opportunities. In the event that, during the Term, Licensor reasonably
determines that it is necessary to license from any third party any intellectual property relating
to the composition of matter, use, manufacture, formulation or exploitation of the Products (“Third
Party IP”) and Licensor desires to license such Third Party IP during the Term, then (i) if
Licensor desires Symphony Dynamo to pay any or all of the financial obligations under such license,
Licensor shall obtain Symphony Dynamo’s written consent, which shall not be unreasonably withheld
or delayed before acquiring such license; and (ii) if Symphony Dynamo provides such consent, then
unless otherwise agreed to by the Parties in writing, Licensor shall use commercially reasonable
efforts to obtain, at the time such license is granted, the right to sublicense such Third Party IP
to Symphony Dynamo consistent with the terms of this Agreement as if such Third Party IP were
Licensed Intellectual Property. Unless otherwise agreed to by the Parties in writing, the
applicable obligations under any licenses to Third Party IP obtained by Licensor with Symphony
Dynamo’s consent shall (1) [ * ]; or (2) [ * ]; or (3) [ * ]. Notwithstanding the foregoing, [ *
].

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

4

 

          2.11. Separate Third Party License for Discontinued Program. In the event of the
expiration of a Discontinuation Option without exercise by Licensor, Symphony Dynamo has the right
to transfer to a third party Symphony Dynamo’s rights to the Products relating to the Program to
which such Discontinuation Option pertained (the “Discontinued Program”). If Symphony Dynamo
identifies a third party that wishes to obtain such rights, then upon Symphony Dynamo’s request,
(i) Licensor and Symphony Dynamo shall amend this Agreement to terminate all of Symphony Dynamo’s
rights and obligations to the extent applicable to the Discontinued Program and (ii) Licensor shall
enter into a separate license agreement with such third party in which all of such terminated
rights and obligations shall be conferred upon and undertaken by such third party. The terms and
conditions of such license agreement shall be identical to those contained herein, to the extent
that such terms are applicable to the Discontinued Program and not dependent on any Operative
Document other than this Agreement. Such terms shall include but not be limited to (1) provisions
allowing for termination of such license agreement upon a material, uncured breach of such license
agreement by the third party on similar terms as provided herein with respect to Symphony Dynamo
and (2) a confidentiality provision that is not dependent on any of the Operative Documents.
Termination of this Agreement shall not effect such license agreement and Licensor’s obligation to
enter into such a license agreement shall survive termination of this Agreement. Notwithstanding
anything to the contrary herein, Licensor shall have no obligation to perform any Dynavax
Obligations with respect to the Discontinued Program following the unexercised expiration of the
Discontinuation Option.

          2.12. Supply of Materials After Expiration or Termination of Term. In the event of an
unexercised expiration or termination of the Purchase Option, Licensor agrees to negotiate in good
faith, and on commercially reasonable terms and conditions, a supply agreement relating to
materials, including compounds and Products, required by Symphony Dynamo (or its partners or
transferees hereunder) for the continued development (including clinical development), manufacture
and commercialization of Products.

ARTICLE 3

SUBLICENSE TO CERTAIN THIRD PARTY INTELLECTUAL PROPERTY

          3.1. General. The Parties hereby acknowledge and agree that the license set forth in
Section 2.2 (a) includes certain intellectual property that has been in-licensed from The
Regents of the University of California (the “Regents”) pursuant to the Exclusive License Agreement
between Licensor and the Regents effective March 26, 1997 and amended July 23, 1997, October 2,
1998, and September 22, 1999 (the “Regents Agreement”); and (b) will, [ * ], include certain
intellectual property that has been in-licensed from Berna Biotech AG (“Berna”) pursuant to the
License and Supply Agreement between Licensor and Berna effective October 28, 2003 (the “Berna
Agreement”).

          3.2. Licensor’s Covenant. In accordance with Section 11.2 of the Amended and
Restated Research and Development Agreement, Licensor covenants to (a) [ * ], and (b) [ * ]
following the occurrence of either: (i) [ * ]; or (ii) [ * ].

          3.3. Sublicense Terms. The license granted by Licensor to Symphony Dynamo under
Section 2.2 is subject to the applicable terms and conditions of the Regents

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

5

 

Agreement, and
provided [ * ], to the terms and conditions of the Berna Agreement. Symphony Dynamo shall, in
exercising such sublicense rights during the Term and after the expiration of an unexercised
Discontinuation Option or expiration of the unexercised Purchase Option, comply with the applicable
provisions of the Regents Agreement and Berna Agreement, including all terms set forth in Annex
C.

ARTICLE 4

INTELLECTUAL PROPERTY

          4.1. Ownership. The Parties acknowledge and agree that, as between Licensor and
Symphony Dynamo, Licensor or its licensors are the owner of all right, title and interest in and to
the Licensed Intellectual Property, including without limitation Symphony Dynamo Enhancements.
Symphony Dynamo hereby assigns to Licensor all of Symphony Dynamo’s rights and interests in any
Symphony Dynamo Enhancements. Symphony Dynamo shall promptly disclose any Symphony Dynamo
Enhancement to Licensor, and shall use reasonable efforts, at Licensor’s request and at no cost to
Licensor, to cooperate fully with Licensor to transfer such Symphony Dynamo Enhancements to
Licensor.

          4.2. Marking. Symphony Dynamo shall mark, and shall cause all of its sublicensees to mark, all Products,
or the packaging thereof or materials related thereto, with the number of the applicable patents
licensed hereunder in accordance with applicable U.S. patent law.

          4.3. Prosecution and Maintenance.

          (a) Unless otherwise set forth in this Section 4.3, (i) Licensor shall prepare, file,
prosecute and maintain those patents and patent applications in Licensed Patent Rights for which
Licensor has patent prosecution and maintenance rights; and (ii) Licensor shall provide Symphony
Dynamo with (1) quarterly reports regarding the status of the prosecution and maintenance of such
patents and patent applications, (2) copies of and/or access to any patent documents as reasonably
requested by Symphony Dynamo, (3) copies of patent applications and other substantive patent
prosecution documents pertaining to the Licensed Patent Rights (and that relate to the Programs,
Products or Symphony Dynamo Products) prior to filing in the United States so as to afford Symphony
Dynamo and its patent counsel, at Symphony Dynamo’s expense, a reasonable opportunity to review and
comment on such documents and (4) timely answers to Symphony Dynamo’s questions regarding the
status of patents and patent applications in Licensed Patent Rights.

          (b) Licensor will use commercially reasonable efforts to seek the allowance of broad generic
claims, consistent with Licensor’s determination of enforceability, business considerations and
other factors.

          (c) Subject to any such costs paid by Third Party Licensors and a reasonable allocation of
costs to the extent that the Licensed Patent Rights claim or describe technologies related to
Licensor’s business other than the Programs, the cost of such prosecution and maintenance of
Licensed Patent Rights shall be paid by Symphony Dynamo. Upon the scope of any Licensed Patent
Rights being amended so that the patent or patent application’s claims no

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

6

 

longer relate to any
Products for which Licensor has not exercised a Program Option or Discontinuation Option, such
patent or patent application shall cease to be a Licensed Patent Right and all rights and
obligations with respect to such patent or patent application (including costs, fees, prosecution,
maintenance and enforcement) shall revert to Licensor.

          (d) Symphony Dynamo shall not be responsible for the costs of any opposition, interference or
reexamination initiated by Licensor with respect to the Licensed Patent Rights (except to the
extent allocated in the Development Budget), unless the Parties mutually agree in writing (i) that
it is reasonably necessary or useful to file and prosecute such opposition, interference or
re-examination in connection with such Licensed Patent Rights to protect their interests in such
Licensed Patent Rights and (ii) to a reasonable allocation of costs to the extent that the Licensed
Patent Rights claim or describe technologies related to Licensor’s business other than the
Programs, which agreement will not be unreasonably withheld or delayed. In the event, however,
that (i) Symphony Dynamo does not agree to pay such costs (or its share of costs as reasonably
allocated as set forth above) of such opposition, interference or reexamination and (ii) Licensor
successfully files and prosecutes such opposition, interference or reexamination at its sole cost,
then the licenses granted by Licensor to Symphony Dynamo in Section 2.2 herein
shall immediately terminate with respect to specific Licensed Patent Rights subject to such
opposition, interference or reexamination.

          (e) Each Party shall provide the prosecuting Party with reasonable cooperation under this
Section 4.3.

          4.4. Abandonment. The Parties acknowledge that in the event Licensor desires to
abandon any patent or patent application covering Licensed Patent Rights (whether during the Term
or in the event of the unexercised expiration or termination of the Purchase Option), Licensor
shall provide prompt, timely, prior written notice of at least [ * ] days prior to abandonment
thereof to Symphony Dynamo before any such abandonment. If Symphony Dynamo informs Licensor in
writing at least [ * ] days before the relevant abandonment deadline that Symphony Dynamo desires
to avoid such abandonment or lapse, then Licensor shall continue to prosecute or maintain such
patent or patent application at Symphony Dynamo’s request and sole expense.

          4.5. Infringement. Each Party agrees to immediately notify the other Party upon
becoming aware of any infringement, misappropriation, illegal use or misuse of the Licensed
Intellectual Property and provide to the other Party all available evidence of such infringement.

          4.6. Enforcement Right During Term.

          (a) During the Term, Licensor has the first right, but not the obligation, to take action
against others in the courts, administrative agencies or otherwise to prevent or terminate
infringement, misappropriation, illegal use or misuse of the Licensed Patent Rights or other
Licensed Intellectual Property due to the manufacture, use or sale of a product that might be
competitive with a Product. The costs and expenses of any such action shall be borne by Symphony
Dynamo to the extent the action relates to the manufacture, use, importation or sale of a product
that might be competitive with a Product for which Licensor has not exercised the

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

7

 

relevant Program Option or Discontinuation Option; provided, that Symphony Dynamo’s written consent was obtained
prior to the initiation of such action, such consent not to be unreasonable withheld or delayed.
Symphony Dynamo shall, at its expense, cooperate with and reasonably assist Licensor in any such
action if so requested by Licensor, and, upon Licensor’s request, execute, file and deliver all
documents and proof necessary for such purpose, including being named as a party to such litigation
if requested by Licensor or if required by Law. Symphony Dynamo shall have the right to
participate and be represented by its own counsel at its own expense in any such action, suit or
proceeding with respect to Licensed Patent Rights solely relating to Products for which Licensor
has not exercised the relevant Program Option or Discontinuation Option provided that Symphony
Dynamo shall not enter into any settlement or compromise of such action, suit or proceeding that
affects or concerns the validity, enforceability, or ownership of any Licensed Patent Rights or
other Licensed Intellectual Property without the prior written consent of Licensor, which consent
shall not be unreasonably
withheld or delayed. Licensor shall not enter into any settlement or compromise of such
action, suit or proceeding that affects or concerns the validity, enforceability, or ownership of
any Licensed Patent Rights or other Licensed Intellectual Property without the prior, written
consent of Symphony Dynamo, which consent shall not be unreasonably withheld or delayed.

          (b) If, during the Term, Symphony Dynamo requests Licensor to take action pursuant to
Section 4.6(a) and Licensor does not take such action within [ * ] days of Symphony
Dynamo’s written request that Licensor take such action, then Symphony Dynamo shall have the option
to commence any such action under its own direction and control, and at Symphony Dynamo’s cost and
expense. Licensor shall, at Symphony Dynamo’s expense, cooperate with and reasonably assist
Symphony Dynamo in any such action if so requested by Symphony Dynamo, and, upon Symphony Dynamo’s
request, execute, file and deliver all documents and proof necessary for such purpose, including
being named as a party to such litigation if requested by Symphony Dynamo or if required by Law.
Licensor shall have the right to participate and be represented by its own counsel at its own
expense in any such action, suit or proceeding with respect to Licensed Patent Rights provided that
Licensor shall not enter into any settlement or compromise of such action, suit or proceeding that
affects or concerns the validity, enforceability, or ownership of any Licensed Patent Rights or
other Licensed Intellectual Property without the prior written consent of Symphony Dynamo, which
consent shall not be unreasonably withheld or delayed. Symphony Dynamo shall not enter into any
settlement or compromise of such action, suit or proceeding that affects or concerns the validity,
enforceability, or ownership of any Licensed Patent Rights or other Licensed Intellectual Property
without the prior, written consent of Licensor, which consent shall not be unreasonably withheld or
delayed.

          4.7. Post-Term Enforcement.

          (a) Following the unexercised expiration or termination of the Purchase Option without
Licensor’s exercise of the Purchase Option, as between the Parties, Symphony Dynamo shall have the
first right, but not the obligation, to take action against others in the courts, administrative
agencies or otherwise, under Symphony Dynamo’s direction and control and at Symphony Dynamo’s cost
and expense, to prevent or terminate infringement, misappropriation, illegal use or misuse of any
Licensed Patent Rights or other Licensed Intellectual Property that

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

8

 

solely relate to a Symphony Dynamo Product for which Licensor has not exercised the relevant Program Option or Discontinuation
Option, due to the manufacture, use, importation or sale of a product that might be competitive
with such Symphony Dynamo Product. Licensor shall, at Symphony Dynamo’s expense, cooperate and
reasonably assist Symphony Dynamo in such action if so requested, and upon Symphony Dynamo’s
request, execute, file and deliver all documents and proof necessary for such purpose, including
being named as a party to such litigation if requested by Symphony Dynamo or if required by Law.
Licensor shall have the right to participate and be represented in any such action, suit or
proceeding by its own counsel at its own expense provided that Licensor shall not enter into any
settlement or compromise of such action, suit or proceeding that affects or concerns the validity,
enforceability, or ownership of any Licensed Patent Rights or other Licensed Intellectual Property
without the prior written
consent of Symphony Dynamo, which consent shall not be unreasonably withheld or delayed.
Symphony Dynamo shall not enter into any settlement or compromise of such action, suit or
proceeding that affects or concerns the validity, enforceability, or ownership of any Licensed
Patent Rights or other Licensed Intellectual Property without the prior written consent of
Licensor, which consent shall not be unreasonably withheld or delayed.

          (b) Following the unexercised expiration or termination of the Purchase Option, if Symphony
Dynamo does not take action under Section 4.7(a) within [ * ] days of Licensor’s written
request that Symphony Dynamo take such action, then Licensor shall have the option to commence any
such action under its own direction and control, and at Licensor’s cost and expense. Symphony
Dynamo shall, at Licensor’s expense, cooperate and reasonably assist Licensor in such action if so
requested, and upon Licensor’s request, execute, file and deliver all documents and proof necessary
for such purpose, including being named as a party to such litigation if requested by Licensor or
if required by Law. Symphony Dynamo shall have the right to participate and be represented in any
such action, suit or proceeding by its own counsel at its own expense provided that Symphony Dynamo
shall not enter into any settlement or compromise of such action, suit or proceeding that affects
or concerns the validity, enforceability, or ownership of any Licensed Patent Rights or other
Licensed Intellectual Property without the prior written consent of Licensor, which consent shall
not be unreasonably withheld or delayed. Licensor shall not enter into any settlement or
compromise of such action, suit or proceeding that affects or concerns the validity,
enforceability, or ownership of any Licensed Patent Rights or other Licensed Intellectual Property
without the prior written consent of Symphony Dynamo, which consent shall not be unreasonably
withheld or delayed.

          4.8. Withdrawal of Enforcement. If either Party brings an action under Sections
4.1 through 4.7, and such Party subsequently ceases to pursue or withdraws from such
action, it shall promptly notify the other Party and the other Party may, to the extent permitted
by Law, substitute itself for the withdrawing party under the terms of this ARTICLE 4.

          4.9. Recoveries. All damages or other compensation of any kind recovered in such
action, suit, or proceeding or from any settlement or compromise brought under Sections 4.1
through 4.7 shall first be used to reimburse each Party for its expenses in connection with
such action, suit or proceeding, (in proportion to the expenses of each Party if recovery is
insufficient to cover all such expenses) and the remainder of such recovery, shall be allocated [ *
].

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

9

 

          4.10. Enforcement For Other Activities. At all times, Licensor shall have the
exclusive right, at its own cost and expense, to prevent or terminate infringement,
misappropriation, illegal use or misuse of any Licensed Patent Rights or other Licensed
Intellectual Property Right due to any activities other than the development, manufacture,
importation, use or sale of product(s) that might be competitive with one or more Symphony Dynamo
Products. Such enforcement activities may be taken in the sole discretion of Licensor and any
damages or other compensation of any kind recovered in such
action, suit or proceeding or from any related settlement or compromise shall be retained by
Licensor.

ARTICLE 5

REPRESENTATIONS AND WARRANTIES

          5.1. Representations and Warranties of Licensor. Licensor hereby represents and
warrants to Symphony Dynamo, that, as of the Closing Date:

          (a) Licensor is the exclusive owner of all right, title, and interest in and to (i) all
Licensed Patent Rights listed in Annex B and not identified as jointly owned or licensed
from a third party and (ii) the Regulatory Files;

          (b) Licensor has sufficient rights to grant the licenses granted hereunder and the grant of
such licenses does not and will not conflict with any agreement to which Licensor is a party or
otherwise governing the Licensed Intellectual Property and Licensor further represents and warrants
that, on an ongoing basis throughout the Term, Licensor shall not enter into any agreement that
will conflict with the rights and licenses granted to Symphony Dynamo hereunder;

          (c) To the Knowledge of Licensor, no third party is engaging in any activity that infringes or
misappropriates the Licensed Intellectual Property;

          (d) No element of the Licensed Intellectual Property has been adjudged invalid or
unenforceable in whole or part, and to the Knowledge of Licensor, the issued patents within the
Licensed Intellectual Property are valid and enforceable;

          (e) To the Knowledge of Licensor, except as set forth on the Closing Certificate for Section
5.1(e), no actions or claims have been asserted, are pending or have been threatened, against
Licensor in writing alleging that the manufacture, use or sale of ISSs or the Products
misappropriates or infringes the intellectual property rights of any third party; and

          (f) To the Knowledge of Licensor, except as set forth on the Closing Certificate for Section
5.1(f), the manufacture, use or sale of ISSs or Products by Symphony Dynamo (or its sublicensees)
in strict accordance with the licenses herein and other terms of this Agreement will not
misappropriate or infringe the intellectual property rights of any third party.

          (g) [ * ]

          5.2. Disclaimer and Acknowledgement. EXCEPT AS EXPRESSLY SET FORTH IN THIS ARTICLE 5,
THE LICENSED INTELLECTUAL PROPERTY, PRODUCTS

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

10

 

(AND THE ISSs THEREIN), TANGIBLE MATERIALS AND
REGULATORY FILES ARE PROVIDED “AS IS” WITH NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, AND
LICENSOR EXPRESSLY
DISCLAIMS ALL OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY
WARRANTIES OF MERCHANTABILITY, FITNESS FOR PARTICULAR PURPOSE, OR NON-INFRINGEMENT. LICENSOR DOES
NOT WARRANT THE PERFORMANCE OF ANY PRODUCT (OR THE ISS THEREIN), INCLUDING THEIR SAFETY,
EFFECTIVENESS OR COMMERCIAL VIABILITY. ANY SYMPHONY DYNAMO ENHANCEMENTS PROVIDED TO LICENSOR
HEREUNDER ARE PROVIDED “AS IS” WITH NO REPRESENTATIONS OR WARRANTIES OF ANY KIND AND SYMPHONY
DYNAMO EXPRESSLY DISCLAIMS ALL WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY
WARRANTIES OF MERCHANTABILITY, FITNESS FOR PARTICULAR PURPOSE, OR NON-INFRINGEMENT.

ARTICLE 6

INDEMNIFICATION AND LIMITATION OF LIABILITY

          6.1. Indemnity. To the greatest extent permitted by applicable Law, Licensor shall
indemnify and hold harmless Symphony Dynamo, its Affiliates, and each of their respective officers,
directors, employees, agents, members, managers, successors and assigns (each, a “Symphony Dynamo
Indemnified Party”) and Symphony Dynamo shall indemnify and hold harmless Licensor, its Affiliates
and each of their respective officers, directors, employees, agents, members, successors and
assigns (each, a “Licensor Indemnified Party” and together with Symphony Dynamo Indemnified Party,
the “Indemnified Parties”), from and against any and all claims, losses, diminution in value,
costs, interest, awards, judgments, penalties, fees (including reasonable fees for attorneys and
other professionals), court costs, liabilities, damages and expenses incurred by any Symphony
Dynamo Indemnified Party or Licensor Indemnified Party (irrespective of whether any such Symphony
Dynamo Indemnified Party or Licensor Indemnified Party, as applicable, is a party to the action for
which indemnification hereunder is sought), (collectively, a “Loss”) as a result of, arising out
of, or relating to any and all third party suits, claims, actions, proceedings, investigations,
litigation or demands based upon:

     (i) in the case of Licensor being the Indemnifying Party (as defined below), (A) any
breach of any representation or warranty made by Licensor herein or in any certificate,
instrument or document delivered in connection and contemporaneously herewith, (B) any
breach of any covenant, agreement or obligation of Licensor contained herein, or in any
certificate, instrument or document delivered hereunder, (C) any act of gross negligence or
willful misconduct by Licensor in performing its obligations under this Agreement, or (D)
the development, manufacture, use, handling, storage, sale or other disposition of any
Product arising from a Program for which Licensor exercised a Program Option or
Discontinuation Option; in each case, except (1) with respect to Losses for which Licensor
is entitled to indemnification under this ARTICLE 6 or (2) to the extent such Loss
arises from the gross negligence or willful misconduct of a Symphony Dynamo Indemnified
Party, and

     (ii) in the case of Symphony Dynamo being the Indemnifying Party, (A) any breach of any
representation or warranty made by Symphony Dynamo herein or in any

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

11

 

certificate, instrument
or document delivered in connection and contemporaneously herewith, (B) any breach of any
covenant, agreement or obligation of Symphony Dynamo contained herein, or in any
certificate, instrument or document delivered hereunder, (C) any act of gross negligence or
willful misconduct by Symphony Dynamo in performing its obligations under this Agreement, or
(D) the development, manufacture, use, handling, storage, sale or other disposition of
Products (other than those Products arising from a Program for which Licensor exercised a
Program Option or Discontinuation Option) after the end of the Term; in each case, except
(1) with respect to Losses for which Symphony Dynamo is entitled to indemnification under
this ARTICLE 6 or (2) to the extent such Loss arises from the gross negligence or
willful misconduct of any Licensor Indemnified Party.

     To the extent that the foregoing undertakings by Licensor and/or Symphony Dynamo may be
unenforceable for any reason, such Party shall make the maximum contribution to the payment and
satisfaction of any Loss that is permissible under applicable Law.

          6.2. Notice of Claims. Any Indemnified Party that proposes to assert a right to be
indemnified under this ARTICLE 6 shall notify Licensor or Symphony Dynamo, as applicable
(the “Indemnifying Party”), promptly after receipt of notice of commencement of any action, suit or
proceeding against such Indemnified Party (an “Indemnified Proceeding”) in respect of which a claim
is to be made under this ARTICLE 6, or the incurrence or realization of any Loss in respect
of which a claim is to be made under this ARTICLE 6, of the commencement of such
Indemnified Proceeding or of such incurrence or realization, enclosing a copy of all relevant
documents, including all papers served and claims made, but the omission to notify the applicable
Indemnifying Party promptly of any such Indemnified Proceeding or incurrence or realization shall
not relieve (a) such Indemnifying Party from any liability that it may have to such Indemnified
Party under this ARTICLE 6 or otherwise, except, as to such Indemnifying Party’s liability
under this ARTICLE 6, to the extent, but only to the extent, that such Indemnifying Party
shall have been prejudiced by such omission, or (b) any other indemnitor from liability that it may
have to any Indemnified Party under the Operative Documents.

          6.3. Defense of Proceedings. In case any Indemnified Proceeding shall be brought
against any Indemnified Party, it shall notify the applicable Indemnifying Party of the
commencement thereof and such Indemnifying Party shall be entitled to participate in, and provided
such Indemnified Proceeding involves a claim solely for money damages and does not seek an
injunction or other equitable relief against the Indemnified Party and is not a criminal or
regulatory action, to assume the defense of, such Indemnified Proceeding with counsel reasonably
satisfactory to such Indemnified Party, and after notice from such Indemnifying Party to such
Indemnified Party of such Indemnifying Party’s election so to assume the defense thereof and the
failure by such Indemnified Party to object to such counsel within ten (10) Business Days following
its receipt
of such notice, such Indemnifying Party shall not be liable to such Indemnified Party for
legal or other expenses related to such Indemnified Proceedings incurred after such notice of
election to assume such defense except as provided below and except for the reasonable costs of
investigating, monitoring or cooperating in such defense subsequently incurred by such Indemnified
Party reasonably necessary in connection with the defense thereof.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

12

 

Such Indemnified Party shall
have the right to employ its counsel in any such Indemnified Proceeding, but the reasonable fees
and expenses of such counsel shall be at the expense of such Indemnified Party unless:

          (a) the employment of counsel by such Indemnified Party at the expense of the applicable
Indemnifying Party has been authorized in writing by such Indemnifying Party;

          (b) such Indemnified Party shall have reasonably concluded in its good faith (which conclusion
shall be determinative unless a court determines that such conclusion was not reached reasonably
and in good faith) that there is or may be a conflict of interest between the applicable
Indemnifying Party and such Indemnified Party in the conduct of the defense of such Indemnified
Proceeding or that there are or may be one or more different or additional defenses, claims,
counterclaims, or causes of action available to such Indemnified Party (it being agreed that in any
case referred to in this clause (b) such Indemnifying Party shall not have the right to
direct the defense of such Indemnified Proceeding on behalf of the Indemnified Party);

          (c) the applicable Indemnifying Party shall not have employed counsel reasonably acceptable to
the Indemnified Party to assume the defense of such Indemnified Proceeding within a reasonable time
after notice of the commencement thereof (it being agreed that in any case referred to in this
clause (c) such Indemnifying Party shall not have the right to direct the defense of such
Indemnified Proceeding on behalf of the Indemnified Party and that this clause (c) shall
not be deemed to constitute a waiver of any conflict of interest that may arise with respect to any
such counsel); or

          (d) any counsel employed by the applicable Indemnifying Party shall fail to timely commence or
diligently conduct the defense of such Indemnified Proceeding and such failure has materially
prejudiced (or, in the reasonable judgment of the Indemnified Party, is in danger of materially
prejudicing) the outcome of such Indemnified Proceeding;

in each of which cases the reasonable fees and expenses of counsel for such Indemnified Party shall
be at the expense of such Indemnifying Party. Only one counsel shall be retained by all
Indemnified Parties with respect to any Indemnified Proceeding, unless counsel for any Indemnified
Party reasonably concludes in good faith (which conclusion shall be determinative unless a court
determines that such conclusion was not reached reasonably and in good faith) that there is or may
be a conflict of interest between such Indemnified Party and one or more other Indemnified Parties
in the conduct of the defense of such Indemnified Proceeding or that there are or may be one or
more different or additional defenses, claims, counterclaims, or causes of action available to such
Indemnified Party.

          6.4.
Settlement. Without the prior written consent of such Indemnified Party, such Indemnifying Party shall
not settle or compromise, or consent to the entry of any judgment in, any pending or threatened
Indemnified Proceeding, unless such settlement, compromise, consent or related judgment (i)
includes an unconditional release of such Indemnified Party from all liability for Losses arising
out of such claim, action, investigation, suit or other legal proceeding, (ii) provides for the
payment of money damages as the sole relief for the claimant (whether at law or in equity), (iii)
involves no finding or admission of any violation of Law or the rights of any Person by the
Indemnified Party, and (iv) is not in the nature of a criminal or

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

13

 

regulatory action. No
Indemnified Party shall settle or compromise, or consent to the entry of any judgment in, any
pending or threatened Indemnified Proceeding in respect of which any payment would result hereunder
or under the Operative Documents without the prior written consent of the Indemnifying Party, such
consent not to be unreasonably conditioned, withheld or delayed.

          6.5. Limitation of Liability. TO THE GREATEST EXTENT PERMITTED BY APPLICABLE LAW,
NEITHER PARTY NOR ANY OF THEIR RESPECTIVE DIRECTORS, OFFICERS, MEMBERS, MANAGERS, EMPLOYEES,
INDEPENDENT CONTRACTORS OR AGENTS SHALL HAVE ANY LIABILITY OF ANY TYPE (INCLUDING, BUT NOT LIMITED
TO, CLAIMS IN CONTRACT, NEGLIGENCE AND TORT LIABILITY) FOR ANY SPECIAL, INCIDENTAL, INDIRECT,
PUNITIVE OR CONSEQUENTIAL DAMAGES, INCLUDING, BUT NOT LIMITED TO, THE LOSS OF OPPORTUNITY, LOSS OF
USE OR LOSS OF REVENUE OR PROFIT IN CONNECTION WITH OR ARISING OUT OF THIS AGREEMENT OR THE
SERVICES PERFORMED HEREUNDER, EVEN IF SUCH DAMAGES MAY HAVE BEEN FORESEEABLE. THE FOREGOING SHALL
NOT LIMIT EITHER PARTY’S INDEMNIFICATION OBLIGATIONS PURSUANT TO THIS ARTICLE 6.

          6.6. Insurance. Each Party shall maintain insurance, including on the part of
Symphony Dynamo, product liability insurance, with respect to its activities under this Agreement.
Such insurance shall be in such amounts and subject to such deductibles as are prevailing in the
industry from time to time. Symphony Dynamo shall maintain a minimum of an aggregate of not less
than $10,000,000 in directors and officers insurance and an aggregate of not less than $10,000,000
in product liability insurance. Notwithstanding anything to the contrary herein, this Section
6.6 shall survive only for a period of two (2) years following termination or expiration of
this Agreement.

ARTICLE 7

TERM AND TERMINATION

          7.1. Term. This Agreement shall commence on the Closing Date and shall remain in
force until terminated as provided herein.

          7.2. Termination.

          (a) Either Party may terminate this Agreement at any time if the other Party is in material
default or breach of this Agreement that has resulted in, or would reasonably be expected to result
in, a material adverse effect on the Programs or the non-breaching Party’s rights under the
Operative Documents, and such material default or breach continues unremedied for a period of [ * ]
days after written notice thereof is delivered to the defaulting or breaching party.

          (b) Licensor may terminate this Agreement at any time upon written notice to Symphony Dynamo
if (i) Investors materially breaches Sections 2 or 3 of the Funding Agreement, (ii) Holdings
breaches Section 2 of the Subscription Agreement or (iii) Holdings or Symphony Dynamo is in
material default or breach the Purchase Option Agreement that has

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

14

 

resulted in, or would reasonably
be expected to result in, a material adverse effect on the Licensor’s rights under the Purchase
Option Agreement and such default or breach is not cured within [ * ] days after written notice of
such default or breach under the Purchase Option Agreement is delivered to the defaulting or
breaching Party.

          (c) Upon any termination of this Agreement, all license rights granted herein (except for
those rights granted in or pursuant to Section 2.5) shall immediately terminate.

          7.3. Survival. The following Sections and Articles shall survive any expiration or
termination of this Agreement: Sections 2.11, 4.1, 5.2 and 7.3,
and Articles 6 and 8.

          7.4. Bankruptcy. All rights and licenses granted under this Agreement are, and shall
otherwise be deemed to be, for purposes of Section 365(n) of the United States Bankruptcy Code (the
“Bankruptcy Code”), licenses to “Intellectual Property” as defined in the Bankruptcy Code. The
Parties agree that each Party shall retain and may fully exercise all of its rights and elections
under the Bankruptcy Code.

ARTICLE 8

MISCELLANEOUS

          8.1. Notices. Any notice, request, demand, waiver, consent, approval or other
communication which is required or permitted to be given to any Party shall be in writing and shall
be deemed given only if delivered to the Party personally or sent to the Party by facsimile
transmission (promptly followed by a hard-copy delivered in accordance with this Section
8.1), by next Business Day delivery by a nationally recognized courier service, or by
registered or certified
mail (return receipt requested), with postage and registration or certification fees thereon
prepaid, addressed to the Party at its address set forth below:

          Licensor:

Dynavax Technologies Corporation

2929 Seventh Street, Suite 100

Berkeley, CA 94710

Attn: Deborah Smeltzer, VP, Operations & CFO

Facsimile: (510) 848-1327

          Symphony Dynamo:

Symphony Dynamo, Inc.

7361 Calhoun Place, Suite 325

Rockville, MD 20855

Attn: Charles W. Finn, Ph.D.

Facsimile: (301) 762-6154

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

15

 

          with a copy to:

Symphony Capital Partners, L.P.

875 Third Avenue

18th Floor

New York, NY 10022

Attn: Mark Kessel

Facsimile: (212) 632-5401

          and

Symphony Strategic Partners, LLC

875 Third Avenue

18th Floor

New York, NY 10022

Attn: Mark Kessel

Facsimile: (212) 632-5401

or to such other address as such Party may from time to time specify by notice given in the manner
provided herein to each other Party entitled to receive notice hereunder.

          8.2. Entire Agreement. This Agreement (including any Annexes, Schedules, Exhibits or
other attachments hereto) and the agreements referred to herein (including the Operative Documents)
constitute the entire agreement between the Parties with respect to the subject matter hereof, and
no oral or written statement may be used to interpret or vary the meaning of the terms and
conditions hereof. This Agreement supersedes any prior or contemporaneous agreements and
understandings, whether written or oral, between the Parties with respect to the subject matter
hereof, including the Original Agreement but excluding the Operative Documents.

          8.3. Assignment. Neither Party may assign or otherwise transfer this Agreement
without the prior written consent of the other Party; provided, however, that (i) Licensor may
assign this Agreement or any of its rights and obligations hereunder without the consent of
Symphony Dynamo (A) to an Affiliate or in connection with a merger or the sale of all or
substantially all of the assets of the Licensor to which this Agreement relates, or (B) to the
Surviving Entity in the event Licensor undergoes a Change of Control in compliance with Article 14
of the Amended and Restated Research and Development Agreement, provided, however, the Licensed
Patent Rights and Licensed Know-How shall not be construed, as a result of such assignment, to
include any patent rights, know-how, trade secret, and other intellectual property that, prior to
such Change of Control, were owned or Controlled by the Person (other than Licensor) involved in
such Change of Control; and (ii) after expiration of the Term without Licensor’s exercise of the
Purchase Option, Symphony Dynamo may assign this Agreement to any Person without the prior, written
consent of Licensor. Assignment of this Agreement by either Party shall not relieve the assignor
of its obligations hereunder. This Agreement shall be binding upon and inure to the benefit of the
Parties and their respective successors and permitted assigns.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

16

 

          8.4. Headings. The descriptive headings contained in this Agreement are for
convenience of reference only and shall not affect in any way the meaning or interpretation of the
Agreement.

          8.5. Independent Contractor. Each Party shall be acting as an independent contractor
in performing under this Agreement and shall not be considered or deemed to be an agent, employee,
joint venturer or partner of the other Party.

          8.6. Severability. If any term or other provision of this Agreement is invalid,
illegal or incapable of being enforced by any Law or public policy, all other terms and provisions
of this Agreement shall nevertheless remain in full force and effect so long as the economic or
legal substance of the transactions contemplated hereby is not affected in any manner materially
adverse to any Party.

          8.7. No Third-Party Beneficiaries. Except with respect to certain indemnification
obligations and liability limitations pursuant to ARTICLE 6, nothing in this Agreement,
either express or implied, is intended to or shall confer upon any third party any legal or
equitable right, benefit or remedy of any nature whatsoever under or by reason of this Agreement.

          8.8. Compliance with Laws. In performing under this Agreement, each Party shall
comply with all applicable Laws, including without limitation, the United States Food and Drug
Administration and the United States Export Administration regulations.

          8.9. Amendment. This Agreement may not be amended or modified except by an instrument
in writing signed by authorized representatives of Licensor and Symphony Dynamo.

          8.10. Governing Law; Consent to Jurisdiction and Service of Process.

          (a) This Agreement shall be governed by, and construed in accordance with, the laws of the
State of New York.

          (b) Each of the Parties hereby irrevocably and unconditionally submits, for itself and its
property, to the nonexclusive jurisdiction of any New York State court or federal court of the
United States of America sitting in The City of New York, Borough of Manhattan, and any appellate
court from any jurisdiction thereof, in any action or proceeding arising out of or relating to this
Agreement, or for recognition or enforcement of any judgment, and each of the Parties hereby
irrevocably and unconditionally agrees that all claims in respect of any such action or proceeding
may be heard and determined in any such New York State court or, to the fullest extent permitted by
Law, in such federal court. Each of the Parties agrees that a final judgment in any such action or
proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment
or in any other manner provided by Law. Nothing in this Agreement shall affect any right that any
Party may otherwise have to bring any action or proceeding relating to this Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

17

 

          (c) Each of the Parties irrevocably and unconditionally waives, to the fullest extent it may
legally and effectively do so, any objection that it may now or hereafter have to the laying of
venue of any suit, action or proceeding arising out of or relating to this Agreement in any New
York State or federal court. Each of the Parties hereby irrevocably waives, to the fullest extent
permitted by Law, the defense of an inconvenient forum to the maintenance of such action or
proceeding in any such court.

          8.11. WAIVER OF JURY TRIAL. EACH OF THE PARTIES HERETO IRREVOCABLY WAIVES ALL RIGHT
TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR
OTHERWISE) ARISING OUT OF OR RELATING TO THIS AGREEMENT.

          8.12. Counterparts. This Agreement may be executed in one or more counterparts, and by the respective Parties
in separate counterparts, each of which when executed shall be deemed to be an original but all of
which taken together shall constitute one and the same Agreement.

          8.13. No Waiver. The failure of either Party to enforce at any time for any period
the provisions of or any rights deriving from this Agreement shall not be construed to be a waiver
of such provisions or rights or the right of such Party thereafter to enforce such provisions.

{SIGNATURES FOLLOW ON NEXT PAGE}

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

18

 

     IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be executed as of the
date first written above by their respective duly authorized officers.

	 	 	 	 	 
	SYMPHONY DYNAMO, INC.	 	 
	 
	 	 	 	 
	By:

	 	/s/ Harri V. Taranto	 	 
	 

	 	 	 	 
	 

	 	Name: Harri V. Taranto	 	 
	 

	 	Title: Chairman of the Board	 	 

	 	 	 	 	 
	SYMPHONY DYNAMO HOLDINGS LLC	 	 
	 	 	 
	By:

	 	     Symphony Capital Partners, L.P.,	 	 
	 

	 	     its Manager	 	 
	 
	 	 	 	 
	By:

	 	     Symphony Capital GP, L.P.,	 	 
	 

	 	     its general partner	 	 
	 
	 	 	 	 
	By:

	 	     Symphony GP, LLC,	 	 
	 

	 	     its general partner	 	 
	 
	 	 	 	 
	By:

	 	/s/ Mark Kessel	 	 
	 

	 	 	 	 
	 

	 	Name: Mark Kessel	 	 
	 

	 	Title: Managing Member	 	 

	 	 	 	 	 
	DYNAVAX TECHNOLOGIES CORPORATION	 	 
	 
	 	 	 	 
	By:

	 	/s/ Dino Dina	 	 
	 

	 	 	 	 
	 

	 	Name: Dino Dina, M.D.	 	 
	 

	 	Title: President & Chief Executive Officer	 	 

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Novated and Restated Technology License Agreement

 

 

ANNEX A

CERTAIN DEFINITIONS

     “$” means United States dollars.

     “Accredited Investor” has the meaning set forth in Rule 501(a) of Regulation D promulgated
under the Securities Act of 1933, as amended.

     “Act” means the Delaware Limited Liability Company Act, 6 Del. C. § 18-101 et seq.

     “Ad Hoc Meeting” has the meaning set forth in Paragraph 6 of Annex B of the Amended and
Restated Research and Development Agreement.

     “Additional Funds” has the meaning set forth in Section 2(b) of the Funding Agreement.

     “Additional Funding Date” has the meaning set forth in Section 3 of the Funding Agreement.

     “Additional Party” has the meaning set forth in Section 13 of the Confidentiality Agreement.

     “Additional Regulatory Filings” means such Governmental Approvals as required to be made under
any law applicable to the purchase of the Symphony Dynamo Equity Securities under the Purchase
Option Agreement.

     “Adjusted Capital Account Deficit” has the meaning set forth in Section 1.01 of the Holdings
LLC Agreement.

     “Affected Member” has the meaning set forth in Section 27 of the Investors LLC Agreement.

     “Affiliate” means, with respect to any Person (i) any Person directly or indirectly
controlling, controlled by or under common control with such Person, (ii) any officer, director,
general partner, member or trustee of such Person, or (iii) any Person who is an officer, director,
general partner, member or trustee of any Person described in clauses (i) or (ii) of this sentence.
For purposes of this definition, the terms “controlling,” “controlled by” or “under common control
with” shall mean the possession, direct or indirect, of the power to direct or cause the direction
of the management and policies of a Person or entity, whether through the ownership of voting
securities, by contract or otherwise, or the power to elect at least 50% of the directors,
managers, general partners, or persons exercising similar authority with respect to such Person or
entities.

     “Amended and Restated Research and Development Agreement” means the Amended and Restated
Research and Development Agreement dated as of the Closing Date, among Dynavax, Holdings and
Symphony Dynamo.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-1

 

     “Asset Value” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “Auditors” means an independent certified public accounting firm of recognized national
standing.

     [ * ]

     “Bankruptcy Code” means the United States Bankruptcy Code.

     “Berna” has the meaning set forth in Section 11.1(a) of the Amended and Restated Research and
Development Agreement.

     “Business Day” means any day other than Saturday, Sunday or any other day on which commercial
banks in The City of New York or the City of San Francisco are authorized or required by law to
remain closed.

     “Cancer Products” mean [ * ].

     “Cancer Program” means the identification, development, manufacture and/or use of any Cancer
Products in accordance with the Development Plan.

     “Capital Contributions” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

     “Capitalized Leases” means all leases that have been or should be, in accordance with GAAP,
recorded as capitalized leases.

     “Cash Available for Distribution” has the meaning set forth in Section 1.01 of the Holdings
LLC Agreement.

     “Chair” has the meaning set forth in Paragraph 4 of Annex B to the Amended and Restated
Research and Development Agreement.

     “Change of Control” means and includes the occurrence of any of the following events, but
specifically excludes (i) acquisitions of capital stock directly from Dynavax for cash, whether in
a public or private offering, (ii) sales of capital stock by stockholders of Dynavax, and (iii)
acquisitions of capital stock by or from any employee benefit plan or related trust:

     (a) the merger, reorganization or consolidation of Dynavax into or with another
corporation or legal entity in which Dynavax’s stockholders holding the right to vote with
respect to matters generally immediately preceding such merger, reorganization or
consolidation, own less than fifty percent (50%) of the voting securities of the surviving
entity; or

     (b) the sale of all or substantially all of Dynavax’s assets or business.

     “Class A Member” means a holder of a Class A Membership Interest.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-2

 

     “Class A Membership Interest” means a Class A Membership Interest in Holdings.

     “Class B Member” means a holder of a Class B Membership Interest.

     “Class B Membership Interest” means a Class B Membership Interest in Holdings.

     “Class C Member” means a holder of a Class C Membership Interest.

     “Class C Membership Interest” means a Class C Membership Interest in Holdings.

     “Closing Certificate for Section 5.1(e)” means the written certificate, pertaining to the
representations made by Dynavax under Section 5.1(e) of the Novated and Restated Technology License
Agreement, provided by Dynavax to Symphony Dynamo Holdings LLC and Symphony Dynamo on the Closing
Date.

     “Closing Certificate for Section 5.1(f)” means the written certificate, pertaining to the
representations made by Dynavax under Section 5.1(f) of the Novated and Restated Technology License
Agreement, provided by Dynavax to Symphony Dynamo Holdings LLC and Symphony Dynamo on the Closing
Date.

     “Client Schedules” has the meaning set forth in Section 5(b)(i) of the RRD Services Agreement.

     “Clinical Budget Component” has the meaning set forth in Section 4.1 of the Amended and
Restated Research and Development Agreement.

     “Closing Date” means April 18, 2006.

     “CMC” means the chemistry, manufacturing and controls documentation as required for filings
with Regulatory Authority relating to the manufacturing, production and testing of drug products.

     “Code” means the Internal Revenue Code of 1986, as amended from time to time.

     “Committed Capital” means $50,000,000.00.

     “Common Stock” means the common stock, par value $0.01 per share, of Symphony Dynamo.

     “Company Expenses” has the meaning set forth in Section 5.09 of the Holdings LLC Agreement.

     “Company Property” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “Confidential Information” has the meaning set forth in Section 2 of the Confidentiality
Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-3

 

     “Confidentiality Agreement” means the Confidentiality Agreement, dated as of the Closing Date,
among Symphony Dynamo, Holdings, Dynavax, each Symphony Fund, SCP, SSP, Investors, Symphony
Capital, RRD and Ann M. Arvin, M.D.

     “Conflict Transaction” has the meaning set forth in Article X of the Symphony 
Dynamo Charter.

     “Control” means, with respect to any material, information or intellectual property right,
that a Party owns or has a license to such item or right, and has the ability to grant the other
Party access, a license or a sublicense (as applicable) in or to such item or right as provided in
the Operative Documents without violating the terms of any agreement or other arrangement with any
third party.

     “Debt” of any Person means, without duplication:

(a) all indebtedness of such Person for borrowed money,

(b) all obligations of such Person for the deferred purchase price of property or services
(other than any portion of any trade payable obligation that shall not have remained unpaid for
91 days or more from the later of (A) the original due date of such portion and (B) the
customary payment date in the industry and relevant market for such portion),

(c) all obligations of such Person evidenced by bonds, notes, debentures or other similar
instruments,

(d) all obligations of such Person created or arising under any conditional sale or other title
retention agreement with respect to property acquired by such Person (whether or not the rights
and remedies of the seller or lender under such agreement in an event of default are limited to
repossession or sale of such property),

(e) all Capitalized Leases to which such Person is a party,

(f) all obligations, contingent or otherwise, of such Person under acceptance, letter of credit
or similar facilities,

(g) all obligations of such Person to purchase, redeem, retire, defease or otherwise acquire for
value any Equity Securities of such Person,

(h) the net amount of all financial obligations of such Person in respect of Hedge Agreements,

(i) the net amount of all other financial obligations of such Person under any contract or other
agreement to which such Person is a party,

(j) all Debt of other Persons of the type described in clauses (a) through (i) above guaranteed,
directly or indirectly, in any manner by such Person, or in effect guaranteed, directly or
indirectly, by such Person through an agreement (A) to pay or purchase such Debt or to advance
or supply funds for the payment or purchase of such Debt, (B) to purchase, sell or lease (as
lessee or lessor) property, or to purchase or sell services, primarily for the purpose of
enabling the debtor to make payment of such Debt or to assure the holder of such Debt against
loss, (C) to supply funds to or in any other manner invest in the debtor

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-4

 

(including any agreement to pay for property or services irrespective of whether such property
is received or such services are rendered) or (D) otherwise to assure a creditor against loss,
and

(k) all Debt of the type described in clauses (a) through (i) above secured by (or for which the
holder of such Debt has an existing right, contingent or otherwise, to be secured by) any
Encumbrance on property (including accounts and contract rights) owned or held or used under
lease or license by such Person, even though such Person has not assumed or become liable for
payment of such Debt.

     “Development Budget” means the budget (comprised of the Management Budget Component and the
Clinical Budget Component) for the implementation of the Development Plan (the initial form of
which was agreed upon by Dynavax and Symphony Dynamo as of the Closing Date and attached to the
Amended and Restated Research and Development Agreement as Annex D thereto), as may be further
developed and revised from time to time in accordance with the Development Committee Charter and
the Amended and Restated Research and Development Agreement.

     “Development Committee” has the meaning set forth in Article 3 of the Amended and Restated
Research and Development Agreement.

     “Development Committee Charter” has the meaning set forth in Article 3 of the Amended and
Restated Research and Development Agreement.

     “Development Committee Member” has the meaning set forth in Paragraph 1 of Annex B to the
Amended and Restated Research and Development Agreement.

     “Development Plan” means the development plan covering all the Programs (the initial form of
which was agreed upon by Dynavax and Symphony Dynamo as of the Closing Date and attached to the
Amended and Restated Research and Development Agreement as Annex C thereto), as may be further
developed and revised from time to time in accordance with the Development Committee Charter and
the Amended and Restated Research and Development Agreement.

     “Development Services” has the meaning set forth in Section 1(b) of the RRD Services
Agreement.

     “Director(s)” has the meaning set forth in the Preliminary Statement of the Indemnification
Agreement.

     “Disclosing Party” has the meaning set forth in Section 3 of the Confidentiality Agreement.

     “Discontinuation Closing Date” has the meaning set forth in Section 11.3 of the Amended and
Restated Research and Development Agreement.

     “Discontinuation Date” means any date designated by Symphony Dynamo which shall occur on or
after the 90th day following the receipt by Dynavax of notice from Symphony

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-5

 

Dynamo of Symphony Dynamo’s intent to discontinue a Program in accordance with the terms of
the Amended and Restated Research and Development Agreement.

     “Discontinuation Option” has the meaning set forth in Section 11.3 of the Amended and Restated
Research and Development Agreement.

     “Discontinuation Price” has the meaning set forth in Section 11.3 of the Amended and Restated
Research and Development Agreement.

     “Discontinuation Price Dispute Notice” has the meaning set forth in Section 11.3(b) of the
Amended and Restated Research and Development Agreement.

     “Discontinued Program” has the meaning set forth in Section 2.11 of the Novated and Restated
Technology License Agreement.

     “Discontinuation Program Funding” has the meaning set forth in Section 11.3(b) of the Amended
and Restated Research and Development Agreement.

     “Disinterested Directors” has the meaning set forth in Article X of the Symphony Dynamo
Charter.

     “Distribution” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “Dynavax” means Dynavax Technologies Corporation, a Delaware corporation.

     “Dynavax Common Stock” means the common stock, par value $0.001 per share, of Dynavax.

     “Dynavax Common Stock Valuation” has the meaning set forth in Section 2(e) of the Purchase
Option Agreement.

     “Dynavax Obligations” has the meaning set forth in Section 6.1 of the Amended and Restated
Research and Development Agreement.

     “Dynavax Personnel” has the meaning set forth in Section 8.4 of the Amended and Restated
Research and Development Agreement.

     “Dynavax Subcontractor” has the meaning set forth in Section 6.2 of the Amended and Restated
Research and Development Agreement.

     “Early Purchase Option Exercise” has the meaning set forth in Section 1(c)(iv) of the Purchase
Option Agreement.

     “Effective Registration Date” has the meaning set forth in Section 1(b) of the Registration
Rights Agreement

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-6

 

     “Encumbrance” means (i) any security interest, pledge, mortgage, lien (statutory or other),
charge or option to purchase, lease or otherwise acquire any interest, (ii) any adverse claim,
restriction, covenant, title defect, hypothecation, assignment, deposit arrangement, license or
other encumbrance of any kind, preference or priority, or (iii) any other security agreement or
preferential arrangement of any kind or nature whatsoever (including, without limitation, any
conditional sale or other title retention agreement).

     “Enhancements” means findings, improvements, discoveries, inventions, additions,
modifications, enhancements, derivative works, clinical development data, or changes to the
Licensed Intellectual Property and/or Regulatory Files, in each case whether or not patentable.

     “Equity Securities” means, with respect to any Person, shares of capital stock of (or other
ownership or profit interests in) such Person, warrants, options or other rights for the purchase
or other acquisition from such Person of shares of capital stock of (or other ownership or profit
interests in) such Person, securities convertible into or exchangeable for shares of capital stock
of (or other ownership or profit interests in) such Person or warrants, rights or options for the
purchase or other acquisition from such Person of such shares (or such other interests), and other
ownership or profit interests in such Person (including, without limitation, partnership, member or
trust interests therein), whether voting or nonvoting, and whether or not such shares, warrants,
options, rights or other interests are authorized or otherwise existing on any date of
determination.

     “ERISA” means the United States Employee Retirement Income Security Act of 1974, as amended.

     “Excepted Debt” has the meaning set forth in Section 5(c)(iii) of the Purchase Option
Agreement.

     “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and
regulations promulgated thereunder.

     “Excluded ISS” means [ * ].

     “Existing NDA” has the meaning set forth in Section 2 of the Confidentiality Agreement.

     “External Directors” has the meaning set forth in the preamble of the Confidentiality
Agreement.

     “FDA” means the United States Food and Drug Administration or its successor agency in the
United States.

     “FDA Sponsor” has the meaning set forth in Section 5.1 of the Amended and Restated Research
and Development Agreement.

     “Final Discontinuation Price” has the meaning set forth in Section 11.3(c) of the Amended and
Restated Research and Development Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-7

 

     “Financial Audits” has the meaning set forth in Section 6.6 of the Amended and Restated
Research and Development Agreement.

     “Financing” has the meaning set forth in the Preliminary Statement of the Purchase Option
Agreement.

     “Fiscal Year” has the meaning set forth in each Operative Document in which it appears.

     “Form S-3” means the Registration Statement on Form S-3 as defined under the Securities Act.

     “FTE” has the meaning set forth in Section 4.1 of the Amended and Restated Research and
Development Agreement.

     “Funding Agreement” means the Funding Agreement, dated as of the Closing Date, among Dynavax,
SCP and Investors.

     “Funding Notice” has the meaning set forth in Section 2(b) of the Funding Agreement.

     “GAAP” means generally accepted accounting principles in effect in the United States of
America from time to time.

     “Governmental Approvals” means authorizations, consents, orders, declarations or approvals of,
or filings with, or terminations or expirations of waiting periods imposed by any Governmental
Authority.

     “Governmental Authority” means any United States or non-United States federal, national,
supranational, state, provincial, local, or similar government, governmental, regulatory or
administrative authority, agency or commission or any court, tribunal, or judicial or arbitral
body.

     “Governmental Order” means any order, writ, judgment, injunction, decree, stipulation,
determination or award entered by or with any Governmental Authority.

     “Hedge Agreement” means any interest rate swap, cap or collar agreement, interest rate future
or option contract, currency swap agreement, currency future or option contract or other similar
hedging agreement.

     “Hepatitis B Products” mean [ * ].

     “Hepatitis B Program” means the identification, development, manufacture and/or use of any
Hepatitis B Products in Accordance with the Development Plan.

     “Hepatitis C Products” mean [ * ].

     “Hepatitis C Program” means the identification, development, manufacture and/or use of any
Hepatitis C Products in Accordance with the Development Plan.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-8

 

     “Holdings” means Symphony Dynamo Holdings LLC, a Delaware limited liability company.

     “Holdings Claims” has the meaning set forth in Section 5.01 of the Warrant Purchase Agreement.

     “Holdings LLC Agreement” means the Amended and Restated Limited Liability Company Agreement of
Holdings, dated as of the Closing Date.

     “HSR Act Filings” means the premerger notification and report forms required under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended.

     “IND” means an Investigational New Drug Application, as described in 21 U.S.C. § 355(i)(1) and
21 C.F.R. § 312 in the regulations promulgated by the United States Food and Drug Administration,
or any foreign equivalent thereof.

     “Indemnification Agreement” means the Indemnification Agreement among Symphony Dynamo and the
Directors named therein, dated as of the Closing Date.

     “Indemnified Party” has the meaning set forth in each Operative Document in which it appears.

     “Indemnified Proceeding” has the meaning set forth in each Operative Document in which it
appears.

     “Indemnifying Party” has the meaning set forth in each Operative Document in which it appears.

     “Independent Accountant” has the meaning set forth in Section 11.3(c) of the Amended and
Restated Research and Development Agreement.

     “Initial Development Budget” means the initial development budget prepared by representatives
of Symphony Dynamo and Dynavax prior to the Closing Date, and attached to the Amended and Restated
Research and Development Agreement as Annex D thereto.

     “Initial Development Plan” means the initial development plan prepared by representatives of
Symphony Dynamo and Dynavax prior to the Closing Date, and attached to the Amended and Restated
Research and Development Agreement as Annex C thereto.

     “Initial Funds” has the meaning set forth in Section 2(a) of the Funding Agreement.

     “Initial Holdings LLC Agreement” means the Agreement of Limited Liability Company of Holdings,
dated January 10, 2006.

     “Initial Investors LLC Agreement” means the Agreement of Limited Liability Company of
Investors, dated January 10, 2006.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-9

 

     “Initial LLC Member” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “Interest Certificate” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

     “Investment Company Act” means the Investment Company Act of 1940, as amended.

     “Investment Overview” means the investment overview describing the transactions entered into
pursuant to the Operative Documents.

     “Investment Policy” has the meaning set forth in Section 1(a)(vi) of the RRD Services
Agreement.

     “Investors” means Symphony Dynamo Investors LLC.

     “Investors LLC Agreement” means the Amended and Restated Agreement of Limited Liability
Company of Investors dated as of the Closing Date

     “IRS” means the U.S. Internal Revenue Service.

     “ISS” means any synthetic oligonucleotide sequence or chimeric oligonucleotide sequence that
modulates an immune response, including, but not limited to, such sequences referred to by Dynavax
as immunostimulatory sequences, chimeric immunomodulatory compounds and branched immunomodulatory
compounds.

     “Knowledge” means the actual (and not imputed) knowledge of the executive officers of Dynavax,
without the duty of inquiry or investigation.

     “Law” means any law, statute, treaty, constitution, regulation, rule, ordinance, order or
Governmental Approval, or other governmental restriction, requirement or determination, of or by
any Governmental Authority.

     “License” has the meaning set forth in the Preliminary Statement of the Purchase Option
Agreement.

     “Licensed Intellectual Property” means the Licensed Patent Rights, Symphony  Dynamo
Enhancements, Licensor Enhancements and the Licensed Know-How.

     “Licensed Know-How” means [ * ].

          (a) “Licensed Patent Rights” means:[ * ].

     “Licensor” means Dynavax.

     “Licensor Enhancements” means [ * ].

     “Lien” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-10

 

     “Liquidating Event” has the meaning set forth in Section 8.01 of the Holdings LLC Agreement.

     “LLC Agreements” means the Initial Holdings LLC Agreement, the Holdings LLC Agreement, the
Initial Investors LLC Agreement and the Investors LLC Agreement.

     “Loss” has the meaning set forth in each Operative Document in which it appears.

     “Management Budget Component” has the meaning set forth in Section 4.1 of the Amended and
Restated Research and Development Agreement.

     “Management Fee” has the meaning set forth in Section 6(a) of the RRD Services Agreement.

     “Manager” means (i) for each LLC Agreement in which it appears, the meaning set forth in such
LLC Agreement, and (ii) for each other Operative Document in which it appears, RRD.

     “Management Services” has the meaning set forth in Section 1(a) of the RRD Services Agreement.

     “Manager Event” has the meaning set forth in Section 3.01(g) of the Holdings LLC Agreement.

     “Material Adverse Effect” means, with respect to any Person, a material adverse effect on (i)
the business, assets, property or condition (financial or otherwise) of such Person or, (ii) its
ability to comply with and satisfy its respective agreements and obligations under the Operative
Documents or, (iii) the enforceability of the obligations of such Person of any of the Operative
Documents to which it is a party.

     “Material Subsidiary” means, at any time, a Subsidiary of Dynavax having assets in an amount
equal to at least 5% of the amount of total consolidated assets of Dynavax and its Subsidiaries
(determined as of the last day of the most recent reported fiscal quarter of Dynavax) or revenues
or net income in an amount equal to at least 5% of the amount of total consolidated revenues or net
income of Dynavax and its Subsidiaries for the 12-month period ending on the last day of the most
recent reported fiscal quarter of Dynavax.

     “Medical Discontinuation Event” means [ * ].

     “Membership Interest” means (i) for each LLC Agreement in which it appears, the meaning set
forth in such LLC Agreement, and (ii) for each other Operative Document in which it appears, the
meaning set forth in the Holdings LLC Agreement.

     “NASDAQ” means the National Association of Securities Dealers Automated Quotation System.

     “NDA” means a New Drug Application, as defined in the regulations promulgated by the United
States Food and Drug Administration, or any foreign equivalent thereof.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-11

 

     “Non-Dynavax Capital Transaction” means any (i) sale or other disposition of all or part of
the Symphony Dynamo Shares or all or substantially all of the operating assets of Symphony Dynamo,
to a Person other than Dynavax or an Affiliate of Dynavax or (ii) distribution in kind of the
Symphony Dynamo Shares following the expiration of the Purchase Option.

     “Non-Symphony Dynamo ISS” means [ * ].

     “Novated and Restated Technology License Agreement” means the Novated and Restated
Technology License Agreement, dated as of the Closing Date, among Dynavax, Symphony Dynamo and
Holdings.

     “Operative Documents” means, collectively, the Indemnification Agreement, the Holdings LLC
Agreement, the Purchase Option Agreement, the Warrant Purchase Agreement, the Registration Rights
Agreement, the Subscription Agreement, the Technology License Agreement, the Novated and Restated
Technology License Agreement, the RRD Services Agreement, the Research and Development Agreement,
the Amended and Restated Research and Development Agreement, the Confidentiality Agreement, the
Funding Agreement and each other certificate and agreement executed in connection with any of the
foregoing documents.

     “Organizational Documents” means any certificates or articles of incorporation or formation,
partnership agreements, trust instruments, bylaws or other governing documents.

     “Partial Stock Payment” has the meaning set forth in Section 3(a)(iii) of the Purchase Option
Agreement.

     “Party(ies)” means, for each Operative Document or other agreement in which it appears, the
parties to such Operative Document or other agreement, as set forth therein. With respect to any
agreement in which a provision is included therein by reference to a provision in another
agreement, the term “Party” shall be read to refer to the parties to the document at hand, not the
agreement that is referenced.

     “Payment Terms” has the meaning set forth in Section 8.2 of the Amended and Restated Research
and Development Agreement.

     “Percentage” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “Permitted Investments” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

     “Permitted Lien” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “Person” means any individual, partnership (whether general or limited), limited liability
company, corporation, trust, estate, association, nominee or other entity.

     “Personnel” of a Party means such Party, its employees, subcontractors, consultants,
representatives and agents.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-12

 

     “Prime Rate” means the quoted “Prime Rate” at JPMorgan Chase Bank or, if such bank ceases to
exist or is not quoting a base rate, prime rate reference rate or similar rate for United States
dollar loans, such other major money center commercial bank in New York City selected by the
Manager.

     “Products” means Cancer Products, Hepatitis B Products and Hepatitis C Products.

     “Profit” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “Program Option” has the meaning set forth in Section 11.1(a) of the Amended and Restated
Research and Development Agreement.

     “Program Option Closing Date” has the meaning set forth in Section 11.1(b) of the Amended and
Restated Research and Development Agreement.

     “Program Option Exercise Date” has the meaning set forth in Section 11.1(b) of the Amended and
Restated Research and Development Agreement.

     “Program Option Exercise Notice” has the meaning set forth in Section 11.1(b) of the Amended
and Restated Research and Development Agreement.

     “Program Option Period” has the meaning set forth in Section 11.1(a) of the Amended and
Restated Research and Development Agreement.

     “Programs” means Cancer Program, Hepatitis B Program and Hepatitis C Program.

     “Protocol” means a written protocol that meets the substantive requirements of Section 6 of
the ICH Guideline for Good Clinical Practice as adopted by the FDA, effective May 9, 1997 and is
included within the Development Plan or later modified or added to the Development Plan pursuant to
the Amended and Restated Research and Development Agreement.

     “Public Companies” has the meaning set forth in Section 5(e) of the Purchase Option Agreement.

     “Purchase Option” has the meaning set forth in Section 1(a) of the Purchase Option Agreement.

     “Purchase Option Agreement” means this Purchase Option Agreement dated as of the Closing Date,
among Dynavax, Holdings and Symphony Dynamo.

     “Purchase Option Closing” has the meaning set forth in Section 2(a) of the Purchase Option
Agreement.

     “Purchase Option Closing Date” has the meaning set forth in Section 2(a) of the Purchase
Option Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-13

 

     “Purchase Option Commencement Date” has the meaning set forth in Section 1(c)(iii) of the
Purchase Option Agreement.

     “Purchase Option Exercise Date” has the meaning set forth in Section 2(a) of the Purchase
Option Agreement.

     “Purchase Option Exercise Notice” has the meaning set forth in Section 2(a) of the Purchase
Option Agreement.

     “Purchase Option Interim Date” has the meaning set forth in Section 2(b)(i) of the Purchase
Option Agreement.

     “Purchase Option Period” has the meaning set forth in Section 1(c)(iii) of the Purchase Option
Agreement.

     “Purchase Price” has the meaning set forth in Section 2(b) of the Purchase Option Agreement.

     “Put Option” has the meaning set forth in Section 2A of the Purchase Option Agreement.

     “Put Option Exercise Notice” has the meaning set forth in Section 2A of the Purchase Option
Agreement.

     “QA Audits” has the meaning set forth in Section 6.5 of the Amended and Restated Research and
Development Agreement.

     “Quarterly Price” has the meaning set forth in Section 2(b)(i) of the Purchase Option
Agreement.

     “Regents” has the meaning set forth in Section 3.1 of the Novated and Restated Technology
License Agreement.

     “Regents Agreement” has the meaning set forth in Section 3.1 of the Novated and Restated
Technology License Agreement.

     “Registration Rights Agreement” means the Registration Rights Agreement dated as of the
Closing Date, between Dynavax and Holdings.

     “Registration Statement” has the meaning set forth in Section 1(b) of the Registration Rights
Agreement.

     “Regulatory Authority” means the United States Food and Drug Administration, or any successor
agency in the United States, or any health regulatory authority(ies) in any other country that is a
counterpart to the FDA and has responsibility for granting registrations or other regulatory
approval for the marketing, manufacture, storage, sale or use of drugs in such other country.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-14

 

     “Regulatory Allocation” has the meaning set forth in Section 3.06 of the Holdings LLC
Agreement.

     “Regulatory Files” means any IND, NDA or any other filings filed with any Regulatory Authority
with respect to the Programs.

     “Related Oncology Products Agreement” has the meaning set forth in Section 11.4 of the Amended
and Restated Research and Development Agreement.

     “Replacement Warrant(s)” has the meaning set forth in Section 7.08 of the Warrant Purchase
Agreement.

     “Representative” of any Person means such Person’s shareholders, principals, directors,
officers, employees, members, managers and/or partners.

     “Research and Development Agreement” means the Research and Development Agreement dated as of
the Closing Date, between Dynavax and Holdings.

     “Rhein” has the meaning set forth in Section 11.1(a) of the Amended and Restated Research and
Development Agreement.

     “Rhein Sale Agreement” has the meaning set forth in Section 11.2(a) of the Amended and
Restated Research and Development Agreement.

     “RRD” means RRD International, LLC, a Delaware limited liability company.

     “RRD Indemnified Party” has the meaning set forth in Section 10(a) of the RRD Services
Agreement.

     “RRD Loss” has the meaning set forth in Section 10(a) of the RRD Services Agreement.

               “RRD Parties” has the meaning set forth in Section 9(e) of the RRD Services Agreement.

     “RRD Personnel” has the meaning set forth in Section 1(a)(ii) of the RRD Services Agreement.

     “RRD Services Agreement” means the RRD Services Agreement between Symphony Dynamo and RRD,
dated as the Closing Date, 2006.

     “Schedule K-1” has the meaning set forth in Section 9.02(a) of the Holdings LLC Agreement.

     “Scheduled Meeting” has the meaning set forth in Paragraph 6 of Annex B of the Amended and
Restated Research and Development Agreement.

     “Scientific Discontinuation Event” has the meaning set forth in Section 4.2(c) of the Amended
and Restated Research and Development Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-15

 

     “SCP” means Symphony Capital Partners, L.P., a Delaware limited partnership.

     “SD Program Option” has the meaning set forth in Section 11.2(b) of the Amended and Restated
Research and Development Agreement.

     “SD Program Option Exercise Notice” has the meaning set forth in Section 11.2(b) of the
Amended and Restated Research and Development Agreement.

     “SEC” means the United States Securities and Exchange Commission.

     “Securities Act” means the Securities Act of 1933, as amended.

     “Selected ISS” means [ * ].

     “Shareholder” means any Person who owns any Symphony Dynamo Shares.

     “Solvent” has the meaning set forth in Section 1.01 of the Holdings LLC Agreement.

     “SSP” means Symphony Strategic Partners, LLC, a Delaware limited liability company.

     “Stock Payment Date” has the meaning set forth in Section 2 of the Subscription Agreement.

     “Stock Purchase Price” has the meaning set forth in Section 2 of the Subscription Agreement.

     “Subcontracting Agreement” has the meaning set forth in Section 6.2 of the Amended and
Restated Research and Development Agreement.

     “Subscription Agreement” means the Subscription Agreement between Symphony Dynamo and
Holdings, dated as the Closing Date.

     “Subsidiary” of any Person means any corporation, partnership, joint venture, limited
liability company, trust or estate of which (or in which) more than 50% of (a) the issued and
outstanding capital stock having ordinary voting power to elect a majority of the board of
directors of such corporation (irrespective of whether at the time capital stock of any other class
or classes of such corporation shall or might have voting power upon the occurrence of any
contingency); (b) the interest in the capital or profits of such partnership, joint venture or
limited liability company; or (c) the beneficial interest in such trust or estate is at the time
directly or indirectly owned or controlled by such Person, by such Person and one or more of its
other Subsidiaries or by one or more of such Person’s other Subsidiaries.

     “Surviving Entity” means the surviving or resulting “parent” legal entity which is surviving
entity to Dynavax after giving effect to a Change of Control.

     “Symphony Capital” means Symphony Capital LLC, a Delaware limited liability company.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-16

 

     “Symphony Dynamo” means Symphony Dynamo, Inc., a Delaware corporation.

     “Symphony Dynamo Auditors” has the meaning set forth in Section 5(b) of the RRD Services
Agreement.

     “Symphony Dynamo Board” means the board of directors of Symphony Dynamo.

     “Symphony Dynamo By-laws” means the By-laws of Symphony Dynamo, as adopted by resolution of
the Symphony Dynamo Board on the Closing Date.

     “Symphony Dynamo Charter” means the Amended and Restated Certificate of Incorporation of
Symphony Dynamo, dated as of the Closing Date.

     “Symphony Dynamo Director Event” has the meaning set forth in Section 3.01(h)(i) of the
Holdings LLC Agreement.

     “Symphony Dynamo Enhancements” means [ * ].

     “Symphony Dynamo Equity Securities” means the Common Stock and any other stock or shares
issued by Symphony Dynamo.

     “Symphony Dynamo Loss” has the meaning set forth in Section 10(b) of the RRD Services
Agreement.

     “Symphony Dynamo Shares” has the meaning set forth in Section 2.02 of the Holdings LLC
Agreement.

     “Symphony Fund(s)” means Symphony Capital Partners, L.P., a Delaware limited partnership, and
Symphony Strategic Partners, LLC, a Delaware limited liability company.

     “Tangible Materials” means [ * ].

     “Tax Amount” has the meaning set forth in Section 4.02 of the Holdings LLC Agreement.

     “Technology License Agreement” means the Technology License Agreement, dated as of the Closing
Date, between Dynavax and Holdings.

     “Term” has the meaning set forth in Section 4(b)(iii) of the Purchase Option Agreement, unless
otherwise stated in any Operative Document.

     “Territory” means the world.

     “Third Party IP” has the meaning set forth in Section 2.11 of the Novated and Restated
Technology License Agreement.

     “Third Party Licensor” means a third party from which Dynavax has received a license or
sublicense to Licensed Intellectual Property.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-17

 

     “Transfer” has for each Operative Document in which it appears the meaning set forth in such
Operative Document.

     “Transferee” has, for each Operative Document in which it appears, the meaning set forth in
such Operative Document.

     “Voluntary Bankruptcy” has the meaning set forth in Section 1.01 of the Holdings LLC
Agreement.

     “Warrant(s)” means the “Warrant” as defined in Section 2.01 of the Warrant Purchase Agreement,
and/or any successor certificates exercisable for Warrant Shares issued by Dynavax.

     “Warrant Closing” has the meaning set forth in Section 2.03 of the Warrant Purchase Agreement.

     “Warrant Date” has the meaning set forth in Section 2.02 of the Warrant Purchase Agreement.

     “Warrant Purchase Agreement” means the Warrant Purchase Agreement, dated as of the Closing
Date, between Dynavax and Holdings.

     “Warrant Shares” has the meaning set forth in Section 2.01 of the Warrant Purchase Agreement.

     “Warrant Surrender Price” has the meaning set forth in Section 7.08 of the Warrant Purchase
Agreement.

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex A to the

Novated and Restated Technology License Agreement

A-18

 

ANNEX B

LICENSED PATENT RIGHTS

[ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex B to the

Novated and Restated Technology License Agreement

B-1

 

ANNEX C

SUBLICENSE TERMS

[ * ]

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED.

Annex C to the

Novated and Restated Technology License Agreement

C-1

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00107-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00107-of-00352.parquet"}]]