Document:

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                                                                   EXHIBIT 10.10

                                    ADDENDUM
                   TO SUPPLY AGREEMENT DATED MARCH 25TH, 2004

             ENTERED INTO AND SIGNED ON THIS 30TH DAY OF JUNE, 2004

BY AND BETWEEN:        OMRIX BIOPHARMACEUTICALS LTD.
                       whose address for the purposes hereof is:
                       MDA Blood center
                       Tel Hasbomer Hospital
                       Kiryat Ono Israel
                       (Hereinafter referred to as: "OMRIX")

                                                              OF THE FIRST PART;

                                       AND

                       PLASTMED LTD. REG. NO. 51-352193-7
                       a company registered in Israel,
                       whose address for the purposes hereof is
                       at 5 Beit Harishomm St.
                       Emek Hefer Industrial Zone 388 00
                       (Hereinafter referred to as: "PLASTMED")

                                                             OF THE SECOND PART:

WHEREAS:    The Parties have entered on March 25th, 2004
            into a manufacture and supply AGREEMENT (hereinafter the
            "AGREEMENT") of Quixil application Devices (as defined in the
            Agreement); and

WHEREAS:    The parties wish to amend certain provisions of the
            Agreement relating to the molds required for the manufacture
            of the Devices and terms of payment relating thereto, as more fully
            set forth in this Addendum to the Agreement (the "ADDENDUM").

NOW THEREFORE IT IS AGREED, DECLARED AND STIPULATED BETWEEN THE PARTIES AS
FOLLOWS:

1.    The Preamble to this Addendum forms an integral part hereof and shall be
      binding upon the parties as the Addendum itself.

2.    This Addendum forms an integral part of the Agreement, and unless
      specifically amended herewith, the provisions of the Agreement shall be
      binding upon the parties hereto and shall remain in full force and effect.

3.    Without prejudice to the provisions of Section 5.2 of the
      Agreement and notwithstanding any other provision or the Agreement or the
      contrary, it is agreed that PlastMed is solely and fully responsible for
      the design and planning of the mold, and that the molds will be ready for
      manufacture of the Devices in not later than 7 (seven) months as of the
      signing date of the Agreement.

      PORTIONS OF THIS EXHIBIT MARKED BY AN *** HAVE BEEN OMITTED PURSUANT
       TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE
                      SECURITIES AND EXCHANGE COMMISSION.

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                                       2

      In view of the passage of time since the date the Agreement was executed
      by the Parties, the Parties hereby agree that all dates and periods
      mentioned therein shall be deemed as postponed and delayed by six weeks.

4.    Payment terms of the amount of (euro) *** (*** Euro) described in
      Section 5.2 of the Agreement are hereby replaced with the following terms:

      4.1.  (euro) *** (*** Euro) designated to cover setup and local expenses,
            shall be paid in advance upon the signing of this Addendum.

      4.2.  The balance in the amount of (euro) *** (*** Euro) shall be paid
            within 30 days of signature hereof (the "BALANCE PAYMENT DATE"),
            against the receipt of" autonomous bank guaranties, as
            stipulated below, issued by one of the leading bank in Israel, in
            the form attached as ANNEX A hereto:

            4.2.1.A Bank Guarantee, in the form attached as ANNEX A hereto
                  (hereinafter: a "BANK GUARANTY"), in the amount of (euro)
                  *** (*** Euro), valid for a period of 20 (TWENTY) WEEKS
                  commencing upon the Balance Payment Date.

                  Without prejudice to the autonomous nature of this Bank
                  Guaranty, Omrix may exercise this Bank Guaranty in the event
                  of failure by PlastMed to supply Omrix detailed design
                  drawings for the following molds Vial Cup 2.5 ml, Vial holder,
                  syringe body and valve care within 14 (fourteen) weeks of the
                  date hereof all in accordance with the amended provisions of
                  the Agreement and the Technical Specifications, attached as
                  Annex A thereto.

                  In the event the above design drawings were delivered on time,
                  Omrix shall have a period of 2 (two) weeks from receipt of
                  such detailed design drawings, to approve or disapprove
                  whether they comply with the Technical Specifications
                  attached as Annex A to the Agreement.

                  In the event of an approval notice, Omrix shall return
                  immediately the Guaranty to PlastMed. In the event of a
                  disapproval notice Omrix shall give written details as to the
                  nature of the disapproval including any and all defect
                  and / or flaws ("DETAILS OF DISAPPROVAL) and PlastMed shall
                  take all actions required in order to correct and amend same
                  within a period of 4 (four) weeks commencing upon the receipt
                  of the Details of Disapproval. Upon the end of such 4 (four)
                  weeks period Omrix shall be entitled to exercise this Bank
                  Guaranty only if PlastMed failed to amend the defects and / or
                  flaws. In any other event, Omrix shall return the Bank
                  Guaranty immediately to PlastMed.
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                                       3

            4.2.2.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 20 (TWENTY) WEEKS commencing upon
                        the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to supply detailed design
                        drawings for the syringe holder molds within 14
                        (fourteen) weeks of the date hereof all in accordance
                        with the amended provisions of the Agreement and the
                        Technical Specifications attached as Annex A thereto.

                        In the event the above design drawings were delivered on
                        time, Omrix shall have a period of 2 (two) weeks of
                        receipt of such detailed design drawings, to approve or
                        disapprove whether they comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed. In the event of a
                        disapproval notice Omrix shall give written details as
                        to the nature of the disapproval including any and all
                        defect and or flaws ("DETAILS OF DISAPPROVAL") and
                        PlastMed shall take all actions required in order to
                        correct and amend same within a period of 4 (four) weeks
                        commencing upon the receipt of the Details of
                        Disapproval. Upon the end of such 4 (four) weeks period
                        Omrix shall be entitled to exercise this Bank Guaranty
                        only if PlastMed failed to amend the defects and / or
                        flaws. In any other event, Omrix shall return the Bank
                        Guaranty immediately to PlastMed.

            4.2.3.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 35 (THIRTY FIVE) WEEKS commencing
                        upon the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to have the following molds
                        supplied: Vial Cup 2.5ml, Vial holder, syringes body and
                        valve core within 30 (thirty) weeks of the date hereof
                        all in accordance with the amended provisions of the
                        Agreement and the Technical Specifications attached as
                        Annex A thereto.

                        In the event the above molds were delivered on time,
                        Omrix shall have a period of 2 (two) weeks of receipt of
                        notice of such delivery, to approve or disapprove
                        whether the molds comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed. In the event of a
                        disapproval notice Omrix shall give written details as
                        to the

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                                       4

                        nature of the disapproval including my and all defect
                        and or flaws ("DETAILS OF DISAPPROVAL") and PlastMed
                        shall take all actions required in order to correct and
                        amend same within a period of 4 (four) weeks commencing
                        upon the receipt of the Details of Disapproval. Upon the
                        end of such 4 (four) weeks period Omrix shall be
                        entitled to exercise this Bank Guaranty only if PlastMed
                        failed to amend the defects and / or flaws. In any other
                        event, Omrix shall return the Bank Guaranty immediately
                        to PlastMed.

            4.2.4.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 37 (THIRTY SEVEN) WEEKS commencing
                        upon the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to have the molds for the
                        syringes holder set supplied within 30 (thirty) weeks of
                        the date hereof all in accordance with the amended
                        provisions of the Agreement and the Technical
                        Specifications attached as Annex A thereto.

                        In the event the above molds were delivered on time,
                        Omrix shall have a period of 2 (two) weeks of receipt of
                        notice of such delivery, to approve or disapprove
                        whether the molds comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed.

                        In the event of a disapproval notice Omrix shall give
                        written details as to the nature of the disapproval
                        including any and all defect and / or flaws ("DETAILS OF
                        DISAPPROVAL") and PlastMed shall take all actions
                        required in order to correct and amend same within a
                        period of four (four) weeks commencing upon the receipt
                        of the Details of Disapproval Upon the end of such 4
                        (four) weeks period Omrix shall of entitled to exercise
                        this Bank Guaranty only if PlastMed failed to amend the
                        defects and / or flaws. In any other event Omrix shall
                        return the Bank Guaranty immediately to PlastMed.

            4.2.5.      A Bank Guarantee in the amount of (euro) *** (*** Euro),
                        valid for a period of 44 (forty four) WEEKS commencing
                        upon the Balance Payment Date.

                        Without prejudice to the autonomous nature of this Bank
                        Guaranty, Omrix may exercise this Bank Guaranty in the
                        event of failure by PlastMed to timely supply the first
                        Purchase Order of Devices, all in accordance with the
                        amended provisions of the Agreement and the Technical
                        Specifications attached as Annex A thereto.

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                                       5

                        In the event of timely delivery, Omrix shall have a
                        period of 4 (four) weeks to approve or disapprove
                        whether the Devices comply with the Technical
                        Specifications attached as Annex A to the Agreement.

                        In the event of an approval notice, Omrix shall return
                        immediately the Guaranty to PlastMed.

                        In the event of a disapproval notice, Omrix shall give
                        written details as to the nature of the disapproval
                        including any and all defect and / or flaws ("DETAILS OF
                        DISAPPROVAL") and PlastMed shall take all actions
                        required in order to correct and amend same within a
                        period of 4 (four) weeks commencing upon the receipt of
                        the Details of Disapproval Upon the end of such 4 (four)
                        weeks period Omrix shall be entitled to exercise this
                        Bank Guaranty only if PlastMed failed to amend the
                        defects and / or flaws. In any other event Omrix shall
                        return the Bank Guaranty immediately to PlastMed.

            For the avoidance of doubt, in the event that Omrix has not
            delivered PlastMed with a written notice of approval or disapproval
            (as the case may be) within the periods prescribed above ("DELAY"),
            all periods and corresponding time bars in the Agreement shall be
            postponed and extended respectively, to reflect any such Delay.

      4.3.  Omrix shall reimburse PlastMed for half of the Bank Guaranty
            expenses

      4.4.  For avoidance of doubt exercise by Omrix of any or all of the Bank
            Guaranties shall not derogate from any right and/or remedy it may
            have under the Agreement and/or the Law, provided that, in any
            event, Omrix shall not be entitled to receive or demand the molds,
            as prescribed in section 5.6 of the Agreement, until after due
            payment of the entire sum in section 4 above and after it has
            returned all the un-exercised Bank Guarantees detailed in
            sub-sections 4.2.1-4.2.5

IN WITNESS WHEREOF THE PARTIES HERETO HAVE SIGNED THIS ADDENDUM:

 /s/ Authorized Officer              /s/ Nissim Mashiach  /s/ Michael Burshtine
-----------------------              ------------------------------------------
       PLASTMED                                       OMRIX
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                                       6

                                    ANNEX A
                                 BANK GUARANTEE

Issuing Bank:

________________
__________ branch,
Tel Aviv, ISRAEL
(the "BANK")

To:
Omrix Biopharmaceuticals Ltd.
MDA Blood center
Tel Hashomer Hospital
Kiryat Ono, Israel
(the "BENEFICIARY")

We hereby establish our irrevocable autonomous Bank Guarantee No.________ (the
"GUARANTEE") in favor of OMRIX BIOPHARMACEUTICALS LTD. (hereinafter the
"BENEFICIARY"), at the request and for the account of PlastMed Ltd. (hereinafter
"PLASTMED") with regard to the Agreement between the Beneficiary and PlastMed
dated March 25th, 2004 and amended on June ____, 2004.

Accordingly, we hereby guarantee and undertake to pay the Beneficiary in
accordance with the terms hereof, a sum which shall not exceed the amount of
____________________________Euro ((euro)_______), within 7 (seven) working days
from receipt of a written original demand duly signed by the Beneficiary.

This Guarantee shall come into force upon remittance by the Beneficiary to
PlastMed's designated account of (euro) *** (*** Euro) and will expire
by_______, and will be considered null and void whether or not it is returned
to us.

This Guarantee is neither transferable nor assignable in any way whatsoever.

This Guarantee shall be governed by and construed according to the laws of the
State of Israel. Any dispute arising under or in relation to this Guarantee
shall be resolved solely and exclusively in the Tel-Aviv-Jaffa competent
courts, and each of the parties hereby submits irrevocably to the jurisdiction
of such courts.

All notices and other communications required or permitted hereunder to be given
to the Bank shall be in writing in the Hebrew or in the English language and
shall be mailed by registered mail, or otherwise delivered by courier, by hand
or by messenger addressed to Bank's address at_____________________________ ,
Tel-Aviv or at such Other address as the Bank shall notify each other party in
writing as above provided.

Yours faithfully,

________________<PAGE>
                                                                   Exhibit 10.11

                                SUPPLY AGREEMENT

This Agreement made and entered into this 24th day of August, 1999 by and among
DAIICHI PHARMACEUTICAL CO., LTD, a company organised and existing under the laws
of Japan having its registered office at 14-10 Nihonbashi 3-chome, Chuo-ku,
Tokyo, Japan (hereinafter called DAICHI) and OMRIX BIOPHARMACEUTICALS SA., a
company organised and existing under the laws of Belgium having its registered
office at 140 Avenue Loise, B2, B-1050 Brussels, Belgium (hereinafter called
OMRIX).

WHEREAS, OMRIX has developed a TWO COMPONENT FIBRIN GLUE for human use
(hereinafter called PRODUCT), comprising a component "A" which comprises a
cryoprecipitate of whole blood and a sufficient amount of Tranexamic Acid
4-(aminomethyl) cyclohexane carboxylic acid (hereinafter called COMPOUND) or its
pharmaceutically acceptable salts and, a component "B" comprising a proteolytic
enzyme being capable of cleaving specifically fibrinogen present in component
"A" and causing the formation of fibrine polymer, and

WHEREAS, OMRIX has applied the patent of the PRODUCT on October 13th, 1994 for
International Patent Classification A61L 25/00, C12N 5/00, International
Publication Number WO 94/22503, and

WHEREAS, OMRIX wishes to stably purchase the compound manufactured by DAIICHI,
which is necessary for manufacturing the PRODUCT, and

<PAGE>

WHEREAS, DAIICHI is willing to accept such wish and designate DAIICHI
PHARMACEUTICAL EUROPE GMBH, DAIICHI's wholly owned subsidiary, a company
organised and existing under the laws of Germany having its registered office at
Immermannstr 50-52, 40210 Dusseldorf, Germany (hereinafter called DPE) as a
supplier of the COMPOUND and OMRIX is willing to accept such designation, and

WHEREAS, OMRIX intends to contract with OMRIX ISRAEL LTD., OMRIX's wholly owned
subsidiary, a company organised and existing under the laws of Israel having its
registered office at Bldg. 14 Kiryat Weizmann, Nes Ziona P.O. Box 619 Rehovot
76106, Israel (hereinafter called OIL), for the manufacturing the PRODUCT for
OMRIX.

NOW, THEREFORE, in consideration of the undertakings of the parties herein
contained, it is hereby agreed as follows:

ARTICLE 1: SUPPLY AND PURCHASE

1.1  DAIICHI hereby shall admit OIL as a contract manufacturer of the PRODUCT
     for OMRIX, and OMRIX shall make OIL observe the articles and the
     provisions of this Agreement. In case OMRIX shall designate any third party
     other than OIL as a contract manufacturer of the product, OMRIX shall
     inform DAIICHI through DPE of the name of that company in advance.

1.2  In accordance with the following terms and conditions, DAIICHI shall supply
     to OMRIX through DPE all OMRIX's requirements of the COMPOUND and OMRIX
     shall purchase the COMPOUND from DAIICHI through DPE for

<PAGE>

     manufacturing the PRODUCT by OIL and selling the PRODUCT. All COMPOUND
     supplied to OMRIX by DAIICHI through DPE hereunder shall be delivered to
     OIL directly. It is hereby understood that OMRIX shall neither export the
     COMPOUND to any third party nor use the COMPOUND for manufacturing other
     products except the PRODUCT without the prior written consent of DAIICHI
     through DPE, which consent shall not be unreasonably withheld.

1.3  Purchase Order

     OMRIX shall place firm orders to DAIICHI through DPE for OMRlX's
     requirements of the COMPOUND not later than ninety (90) days before the
     expected date of shipment. DAIICHI shall notify OMRIX through DPE of its
     receipt and DAIICHI shall inform OMRIX through DPE of the date of shipment
     in advance. In the event that DAIICHI through DPE notify OMRIX that DAIICHI
     cannot fulfil such orders, the parties hereto shall negotiate in good
     faith. All orders by OMRIX shall be made on a multiple of fifty (50)
     kilogram.

1.4  Estimate of Purchase

     OMRIX shall notify DAIICHI through DPE every year during the term of this
     Agreement, not later than ninety (90) days prior to the beginning of each
     calendar year, of OMRIX monthly purchase estimation of the COMPOUND for the
     next full calendar year.

ARTICLE 2: PRICE AND PAYMENT

DAIICHI and OMRIX shall negotiate the price and the payment term of the COMPOUND
in separate of this Agreement

<PAGE>

ARTICLE 3: SPECIFICATIONS AND CLAIMS FOR DEFECTS

3.1  The COMPOUND supplied hereunder shall meet the specifications attached in
     Annex A. It is hereby understood that the COMPOUND shall meet the
     specifications of Tranexamic Acid monograph in European Pharmacopeia.
     Whenever the specifications of Tranexamic Acid monograph shall be changed,
     the specifications of the COMPOUND shall be changed accordingly.

3.2  DPE shall attach a certificate of analysis executed by DAIICHI to the
     respective documents for each shipment of the COMPOUND.

3.3  Promptly after OIL receives each shipment of the COMPOUND, OMRIX shall have
     OIL carry out the inspection and testing. The COMPOUND shall be considered
     to comply with the specifications, if OIL through OMRIX, does not notify
     DAIICHI through DPE of any objections within ninety (90) days after receipt
     of such Shipment.

3.4  In the event that OIL through OMRIX, notifies DAIICHI through DPE within
     ninety (90) days after receipt of shipment of the COMPOUND that such
     COMPOUND does not comply with the specifications and presents to DAIICHI
     through DPE an evidence for any defect, DAIICHI through DPE shall either
     replace the defective COMPOUND free of charge or credit the invoiced amount
     for such detective COMPOUND to OMRIX, and DAIICHI and DPE (hereinafter
     collectively called DAIICHI GROUP) shall not bear any other liability It is
     understood, however, that OIL, on behalf of OMRIX shall not return to
     DAIICHI through DPE any defective shipment of the COMPOUND without the
     prior consent of DAIICHI through DPE.

<PAGE>

ARTICLE 4: REPORT

4.1  OMRIX shall submit DAIICHI through DPE its quarterly reports on the use of
     the COMPOUND for the PRODUCT on monthly basis within thirty (30) days after
     the end of such calendar quarter.

4.2  OMRIX shall inform DAIICHI through DPE of its stock quantity of the
     COMPOUND on the last day of each quarter within thirty (30) days after the
     end of such calendar quarter.

ARTICLE 5: EXCHANGE OF INFORMATION

5.1  DAIICHI GROUP and OMRIX shall furnish each other on regular basis with
     information and data relating to the PRODUCT and/or the COMPOUND which
     either party considers useful to the other party, such as clinical
     application and sales promotion, to be obtained by either party during the
     terms hereof. Either DAIICHI GROUP or OMRIX has the right to use and to
     have used such information and data free of charge.

5.2  OMRIX shall provide DAIICHI through DPE with two packages of the PRODUCT
     and insert-sheet before its launch. Whenever any substantial changes in the
     PRODUCT and/or the insert sheet of the PRODUCT provided to DAIICHI shall be
     made, OMRIX shall inform DAIICHI through DPE of with two packages of the
     PRODUCT including insert-sheets as free of charge as soon as possible.

5.3  DAIICHI through DPE shall promptly provide to OMRIX, by the CIOMS form
     (COUNCIL FOR INTERNATIONAL ORGANIZATIONS OF MEDICAL SCIENCES), with
     necessary information and data relating to serious side effects and/or
     serious adverse events, associated with the use of the finished preparation

<PAGE>

     for human use containing the COMPOUND as the active ingredient, if reported
     to DAIICHI from any sources.

5.4  OMRIX shall promptly provide to DAIICHI through DPE. by the CIOMS form
     (COUNCIL FOR INTERNATIONAL ORGANIZATIONS OF MEDICAL SCIENCES), with
     necessary information and data relating to serious side effects and/or
     serious adverse events, associated with the use of the PRODUCT, if reported
     to OMRIX from any sources.

The terms "Serious" provided for in the paragraph 5.3 and 5.4 above have the
following meaning:

          -    result in death

          -    life-threatening

          -    inpatient hospitalisation or prolongation of existing
               hospitalisation

          -    result in persistent or significant disability/incapacity

          -    congenital anomaly/birth defect

          -    other medically important condition

5.5  Promptly after the execution of this agreement and from time to time during
     the term of this agreement, DAIICHI through DPE shall provide OMRIX with
     the current valid Certificate of Suitability of the COMPOUND.

ARTICLE 6.: SALES AND PROMOTION

6.1  OMRIX shall sell and promote the PRODUCT in its own responsibility and
     expenses.

6.2  OMRIX shall 'notify DAIICHI through DPE the names of the distributors in
     each country where the PRODUCT is marketed.

<PAGE>

6.3  OMRIX shall use its own trademark "QUIXIL" as the tradename of the PRODUCT
     in Israel and Mexico. OMRIX shall inform the tradename of the PRODUCT of
     each country to DAIICHI through DPE before its launch.

ARTICLE 7.: SECRECY

7.1  Each party (hereinafter called the RECEIVING PARTY) shall keep strictly
     secret and confidential the information and data received from the other
     party (hereinafter called the DISCLOSING PARTY) under this Agreement
     except:

     a)   information and data which at the time of disclosure by the DISCLOSING
          PARTY are in the public domain

     b)   information and data which after disclosure by the DISCLOSING PARTY
          enter the public domain through no improper conduct of the RECEIVING
          PARTY;

     c)   information and data which prior disclosure by the DISCLOSING PARTY
          were already in the possession of the RECEIVING PARTY as evidenced by
          the RECEIVING PARTY'S written records;

     d)   information and data which subsequent to disclosure hereunder are
          obtained by the RECEIVING PARTY from third parties, who are lawfully
          in possession of such information and data who do not require
          RECEIVING PARTY to refrain from disclosing such information and data
          to others.

7.2  The provisions of the paragraph 7.1 hereof shall not apply to the extent
     that it may be necessary to disclose, on the confidential basis, said
     information and data to OIL, the RECEIVING PARTY'S outside experts for the
     purpose of this Agreement.

<PAGE>

ARTICLE 8.: HOLD HARMLESS

OMRIX shall assume and hold DAIICHI GROUP harmless from any responsibility and
liability for any damages, either direct or indirect, or consequential damages,
sustained or alleged to have been sustained, by any person or persons in
connection with the COMPOUND or PRODUCT, unless such damages are the result of
DAIICHI GROUP'S negligence.

ARTICLE 9.: DURATION AND TERMINATION

9.1  This Agreement shall continue in full force and effect for a period of five
     (5) years from the date of execution of this Agreement and shall be
     automatically renewed for subsequent two (2) years period each unless not
     less than 6 months before the expiration of the term of this Agreement
     either party shall notify the other party of its desire to terminate this
     Agreement.

9.2  Upon any breach, default or other defect of performance by either party
     under this Agreement the other party may terminate this Agreement by ninety
     (90) days written notice. The said notice shall become effective at the end
     of the said ninety (90) day period unless the party in breach shall remedy
     such breach, default or other defect or performance during the said ninety
     day period.

ARTICLE 10.: FORCE MAJEURE

Neither party shall be responsible for a failure or a delay in performance of
any of its obligations under this Agreement due to force majeure such as, but
not limited to, governmental orders of restrictions, war, fire, flood,
earthquake, embargo, accident, explosion, strike, lockout or other labour
disputes or any other cause beyond the control

<PAGE>

of the parties concerned. The parties shall use due diligence to remove any such
causes and to resume performance as soon as it is reasonably feasible.

ARTICLE 11.: APPLICABLE LAW

This Agreement and any additional agreement to be executed in connection
therewith between the parties hereto shall be prepared in English language. This
Agreement and the said additional agreement shall be governed by and construed
in accordance with the laws of United Kingdom.

ARTICLE 12.: ARBITRATION

All disputes, controversies, or differences which may arise between the parties
hereto, out of or in relation to or in connection with this Agreement, or for
the breach thereof, shall be settled by arbitration. If the arbitration is
initiated by DAIICHI, it shall be held in Brussels, Belgium in accordance with
the rules of the International Chamber of Commerce. If the arbitration is
initiated by OMRIX, it shall be held in Tokyo, Japan in accordance with the
rules of the Japan Commercial Arbitration Association. The award shall be final
and binding upon the parties hereto.

ARTICLE 13.: NOTICE

13.1 Any notice given by one party hereto to the other hereunder shall be made
     by registered air mail, provided, however, that as for an urgent matter
     facsimile or telex may be used, in which case the issuing party shall give
     the notice to the receiving party to confirm the contents promptly.

<PAGE>

13.2 The notice under the preceding paragraph, unless otherwise provided, shall
     be deemed to be effective upon its receipt by the receiving party. The said
     notice shall be given to the address of the receiving party first above
     written unless or until the address is changed by notice.

ARTICLE 14.: NON-WAIVER

No omission or delay of either party hereto in requiring due and punctual
fulfilment by other party of the obligations of such other party hereunder shall
be deemed to constitute a waiver by such party of its right to require such due
and punctual fulfilment or of any of its remedies hereunder.

ARTICLE 15.: MISCELLANOUS

15.1 If one or more provisions of this Agreement shall to any extent be invalid
     or unenforceable under any applicable law, the remainder of this Agreement
     shall not be not be affected thereby and shall be valid and enforceable to
     the fullest extent permitted by applicable law. The parties shall cooperate
     in amending this Agreement in order to replace the invalid provision(s) by
     valid provision(s) having economic effects as close as possible to the
     invalid one(s).

15.2 The captions of Article in this Agreement are for convenience only, and
     this Agreement shall not be constructed or interpreted by reference to such
     captions.

15.3 This Agreement constitutes the entire Agreement between the parties hereto
     concerning the subject matter hereof and any representation, promise or
     condition not incorporated in this Agreement, shall not be binding upon
     either party.

<PAGE>

15.4 Independent Contractors. The relationship of the parties hereto is that of
     independent contractors. The parties hereto are not deemed to be agents,
     partners or joint ventures of the others for any purpose as a result of
     this Agreement or the transactions contemplated thereby.

15.5 This Agreement shall not be assignable by either party to any third party
     hereto without the written consent of the parties hereto.

IN WITNESS WHEREOF the parties hereto have caused this Agreement to be executed
by their duly authorised officers upon the date first above written in duplicate
original, one (1) original to be retained by DAIICHI and OMRIX.

DAIICHI PHARMACEUTICAL CO., LTD.

/s/ Y. Konno
-------------------------------------
Date Aug 24, 1999

OMRIX BIOPHARMACEUTICALS SA

/s/ Robert Taub
-------------------------------------
Date Sept 02, 1999

Accepted & Attested by:

DAIICHI PHARMACEUTICAL EUROPE GMBH

/s/ Hideyuki Nakajima
-------------------------------------
Date Aug 26, 1999

<PAGE>

                                     ANNEX A

               SPECIFICATIONS AND TEST METHODS OF TRANEXAMIC ACID

<TABLE>
<CAPTION>
TESTS                   LIMITS                            METHODS
-----                   ------                            -------
<S>                     <C>                               <C>
APPEARANCE              A white crystalline powder        Visual Inspection

IDENTIFICATION          Spectrum, confirms to reference   Ph-Eur<875>
                        spectrum

PH (5% W/W SOLUTION)    6.5-8.0                           Ph-Eur<875>

CLARITY AND COLOUR OF   Clear and colourless              JP X III
SOLUTION

RELATED SUBSTANCES      Max 1.0%                          Ph-Eur<875>

CIS-AMC                 Max 0.5%                          Ph-Eur<875>

BROMIDES                Max 670 ppm                       Ph-Eur<875>

HEAVY METALS            Max 20ppm                         Ph-Eur<875>

LOSS ON DRYING          Max 0.5% w/w                      Ph-Eur<875>

SULPHATED ASH           Max 0.1% w/w                      Ph-Eur<875>

ASSAY TRANEXAMIC ACID   99 0-101.0%                       Ph-Eur<875>

PYROGEN TEST            (--)                              JP X III
</TABLE>

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00096-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00096-of-00352.parquet"}]]