Document:

EX-10.27

 Exhibit 10.27 

Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would likely cause
competitive harm to the Company, if publicly disclosed. Double asterisks denote omissions. 
 AGREEMENT 

AGREEMENT, dated as of June 19, 2003 (the “Effective Date”), between THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW
YORK (“Columbia”), a New York corporation, and SCHRÖDINGER, L.L.C. (“Schrödinger”), a Delaware limited liability company. 

WHEREAS, Professor Richard A. Friesner of Columbia University and Professor [**] of the [**], are the authors of the Protein Local
Optimization Program; 
 WHEREAS, all right, title and interest in the Protein Local Optimization Program have been assigned to Columbia and
to The Regents of the University of California (“UC”) by the authors thereof; 
 WHEREAS, UC and Columbia have entered into an
interinstitutional agreement (the “IIA,” a copy of which is attached hereto as Exhibit A) whereby UC has given Columbia sole responsibility for the licensing of the PLOP Code and University Improvements (as hereinafter defined) to
third parties; 
 WHEREAS, pursuant to the IIA, UC has agreed not to license the PLOP Code and/or University Improvements to any third party
as long as the IIA is in effect (except to the extent of UC’s obligations to the federal government if the University Improvements are created under funding provided by the Federal Government); and 

WHEREAS, Columbia and UC wish to license to Schrödinger the PLOP Code and any modifications and improvements to the PLOP Code that may be
developed at Columbia and/or UC in the future, and Schrödinger wishes to obtain such a license in order to be able to (i) market and distribute the PLOP Code and modifications and improvements thereto as (and/or as part of) a commercial
product or commercial products, (ii) make use of the PLOP Code in the course of providing services to third parties, and/or (iii) make or permit use of the PLOP Code in connection with scientific or technical research projects undertaken
by Schrödinger or its Affiliates (as hereinafter defined). 
 NOW, THEREFORE, the parties agree as follows: 

1.    Definitions. 

a.    “Affiliate” shall mean any corporation or other business entity which directly or indirectly controls, is
controlled by, or is under common control with another corporation or business entity. Control means ownership or other beneficial interest in 50% or more of the voting stock or other voting interest of a corporation or other business entity. D. E.
Shaw Research and Development, L.L.C. (which is Schrödinger’s managing member as of the date hereof) shall be considered an Affiliate of Schrödinger. 

 b.    “Gross Revenues” shall mean all fees or other payments
received by Schrödinger and Affiliates of Schrödinger for licensing, selling, leasing, or renting any Software Product (as hereinafter defined); provided, however, that fees or other payments received by Schrödinger in connection with
the licensing, selling, leasing, or renting of a Software Product to Columbia or UC shall not constitute Gross Revenues, and provided further that fees or other payments constituting Services Fees (as hereinafter defined) shall not constitute Gross
Revenues. In the event that one or more Software Products are sold together with other products (such sale a “Multiple Product Sale”) for a single aggregate license fee (a “Multiple Product License Fee”), Gross Revenues shall
mean the fraction of the Multiple Product License Fee attributable to the Software Product(s), as calculated by multiplying the Multiple Product License Fee by a fraction whose numerator is the then-current aggregate list price of any Software
Products included in the Multiple Product Sale (or the aggregate number of tokens associated with such Software Product(s)) and whose denominator is the then-current aggregate list price of all products included in the Multiple Product Sale (or the
aggregate number of tokens associated with all products included in the Multiple Product Sale). 
 By way of example only and without
limiting the foregoing: 
 [**]. 

c.    “Non-University Code” shall mean (i) any code developed by
Schrödinger or by any other party other than (A) Columbia or UC and/or (B) faculty members, other employees, or students of Columbia or UC that is incorporated in a Software Product, and (ii) associated documentation. 

d.    “PLOP Code” shall mean software code developed at Columbia or UC constituting the Protein Local
Optimization Program as described in Exhibit B. “Columbia Code” shall mean that portion of the PLOP Code developed at Columbia. “UC Code” shall mean that portion of the PLOP Code developed at UC. 

e.    “Schrödinger Improvements” shall mean any corrections, modifications and improvements to the PLOP
Code developed by employees, agents or contractors of Schrödinger or of Schrödinger’s Affiliates. 

f.    “Schrödinger-Columbia Agreement” shall have the meaning set forth in Section 5.c. 

g.    “Services Agreement” shall mean an agreement between Schrödinger or an Affiliate of Schrödinger
and one or more third parties under which Schrödinger undertakes to perform services using a Software Product (as hereinafter defined) on behalf of, or in collaboration with, such third parties in return for fees or other payments (any such
fees or payments, “Services Fees”); provided, however, that fees or other payments received by Schrödinger in connection with a Services Agreement between Schrödinger and Columbia and/or UC, shall not constitute Services Fees,
and provided further that fees or other payments constituting Gross Revenues shall not constitute Services Fees. 

h.    “Software Product” shall mean any commercial product, software program or code sold or marketed by
Schrödinger or an Affiliate of Schrödinger or a distributor of Schrödinger or an Affiliate of Schrödinger incorporating in whole or in part, the PLOP Code or any University Improvements, including each new version or release
thereof. 

  
 2 

 i.    “Unassigned Improvements” shall mean any corrections,
modifications and improvements to the PLOP Code made by Columbia or UC and/or by faculty members, other employees, or students of Columbia or UC that have not been assigned to Columbia and/or UC. 

j.    “University Improvements” shall mean (i) software code comprising all corrections, modifications and
improvements to the PLOP Code developed by Columbia and/or UC faculty members or other employees or students of Columbia or UC, which are (A) assigned in writing to Columbia or UC pursuant to such university’s policies on intellectual
property rights in effect at the time such corrections, modifications or improvements are disclosed to Columbia or UC in accordance with such policies, provided, however, that solely with respect to UC, such software code shall be considered a
“University Improvement” only if it was developed within [**] following the effective date of the IIA; or (B) otherwise assigned to Columbia or UC, and (ii) associated documentation. 

2.    License Grant and Title. 

a.    Subject to the terms and conditions hereinafter set forth, Columbia hereby grants to Schrödinger a license to:

 (i)    reproduce, use, execute, copy, compile, operate, sublicense and distribute the PLOP Code in connection with
(A) the marketing, licensing and distribution of the PLOP Code and/or a Software Product or Software Products, provided, however, that with respect to distribution, only the object code of the PLOP Code will be distributed and further provided
that, should Schrödinger desire to distribute the source code of the PLOP Code (such transaction, a “PLOP Source Code Transaction”), Schrödinger shall give Columbia written notice (containing a reasonable summary of terms) of and
obtain Columbia’s written approval, which approval shall not be unreasonably withheld or delayed, to such PLOP Source Code Transaction and further provided that, should a written response (containing reasonable detail regarding Columbia’s
reason for denying such request, if such written response consists of a denial of approval) by Columbia not be received by Schrödinger within [**] following Schrödinger’s delivery of the foregoing notice, Columbia’s approval to
such PLOP Source Code Transaction will be deemed to be given; and (B) providing services pursuant to a Services Agreement or Services Agreements; 

(ii)    reproduce, use, execute, copy, compile, operate, sublicense and distribute the University Improvements in
connection with (A) the marketing, licensing and distribution of the PLOP Code and/or a Software Product or Software Products, provided, however, that with respect to distribution, only the object code of the University Improvements will be
distributed and further provided that, should Schrödinger desire to distribute the source code of the University Improvements (such transaction, a “University Improvement Source Code Transaction”), Schrödinger shall give Columbia
written notice (containing a reasonable summary of terms) of and obtain Columbia’s written approval, which approval shall not be unreasonably withheld or delayed, to such University Improvement Source Code Transaction and further provided that,
should a written response (containing reasonable detail regarding Columbia’s reason for denying such request, if such written response consists of a denial of approval) by Columbia not be received by Schrödinger within [**] following
Schrödinger’s delivery of the foregoing notice, Columbia’s approval to such University Improvement Source Code Transaction will be deemed to be given; and (B) providing services pursuant to a Services Agreement or Services
Agreements; 

  
 3 

 (iii)    develop Schrödinger Improvements (and permit
Schrödinger’s Affiliates to do so); and 
 (iv)    reproduce, use and execute the PLOP Code (and permit
Schrödinger’s Affiliates to do so) for purposes of (A) conducting scientific or technical research, and (B) back-up and disaster recovery. 

For avoidance of doubt, it is the intent of Columbia, by the foregoing licenses, to grant Schrödinger and its Affiliates all necessary
rights and licenses under any patents arising out of or relating to the PLOP Code, trademarks, copyrights and any other intellectual property and proprietary rights held by Columbia and UC (not including patents other than those arising out of or
relating to the PLOP Code) to the extent such patents arising out of or relating to the PLOP Code, trademarks, copyrights and any other intellectual property and proprietary rights would otherwise be infringed by Schrödinger’s or, as
applicable, Schrödinger’s Affiliates’ use of the PLOP Code in accordance with this Agreement. Nothing in this Agreement confers by estoppel, implication, or otherwise any license or rights under any patents of UC or Columbia other
than patents arising out of or relating to the PLOP Code. 
 b.    The licenses granted under Section 2.a hereof
shall be worldwide, exclusive licenses whose term shall be (subject to the terms and conditions of this Agreement) perpetual. Columbia and UC will make reasonable efforts to obtain assignments from any authors of Unassigned Improvements proposed to
be incorporated in any new release of a Software Product who have not previously assigned such Unassigned Improvements to Columbia or UC and, in the event Columbia or UC is successful in obtaining such assignments from any such authors,
(i) Columbia shall so notify Schrödinger in writing, and (ii) such Unassigned Improvements for which Columbia or UC has obtained assignments shall be deemed to be University Improvements. Columbia and UC shall not deliver an
Unassigned Improvement to Schrödinger unless Columbia or UC has obtained assignments from all authors of such Unassigned Improvement. 

c.    Columbia represents and warrants to Schrödinger that, subject to the provisions of 35 U.S.C. §200
et. seq. and the implementing regulations of OMB Circular No. A-110, (i) Columbia has title to the PLOP Code and the University Improvements and that Columbia has full legal right and power to
grant to Schrödinger the licenses granted under this Agreement, and (ii) UC, to the best of the knowledge of the UC licensing officer responsible for the PLOP Code, has title to the PLOP Code. 

d.    This Agreement shall not transfer any title or ownership rights in the PLOP Code, University Improvements or
Unassigned Improvements, which shall at all times remain with Columbia and UC or, as applicable, the original author(s). 

  
 4 

 e.    As between Columbia and UC on one hand and Schrödinger on the
other, Schrödinger shall own all right, title and interest in and to the Software Products (excluding any portions of the PLOP Code and University Improvements incorporated therein), and any updates, modifications or improvements thereto
(except for University Improvements) or derivative works thereof (excluding (i) derivative works of the PLOP Code other than Schrödinger Improvements and (ii) University Improvements), including without limitation all copyright,
patent, trademark, trade secret and other proprietary rights therein or thereto. 
 f.    All rights granted by Columbia
to Schrödinger under this Agreement are subject to the requirements of 35 U.S.C. §200 et. seq., as amended, and the implementing regulations of OMB Circular No. A-110. 

g.    Schrödinger shall not sublicense the PLOP Code to be incorporated in a product that is not sold directly by
Schrödinger or distributed on Schrödinger’s behalf by a distributor of Schrödinger. 
 3.    No
Maintenance. It is understood that Columbia and UC will provide no maintenance or installation services of any kind hereunder. Columbia or UC may, in their sole discretion, use reasonable efforts to assist Schrödinger in correcting errors
in the PLOP Code, University Improvements or Unassigned Improvements brought to Columbia’s or UC’s attention by Schrödinger; provided, however, that Columbia or UC will not be considered in breach of this Agreement if it
either is unable to do so after reasonable efforts or elects not to do so. 
 4.    Licensing of Software by
Schrödinger. 
 Schrödinger shall cause any license agreement for, or agreement for maintenance of, a Software Product entered
into between Schrödinger and a customer of Schrödinger, and any agreement sub-licensing the rights granted by this Agreement, to: 

a.    make adequate provision for the protection of the confidentiality of the PLOP Code and University Improvements
provided to the licensee, by requiring protections of at least the same scope as required under Section 6 hereof; 

b.    include a disclaimer provision that is substantially equivalent to that set forth in Section 10 hereof; and

 c.    provide that neither Columbia nor UC shall be required pursuant to such agreement to provide any maintenance or
installation or support services of any kind, whatsoever. 
 5.    Calculation of Royalties. 

a.    In consideration of the licenses granted under Section 2 of this Agreement, Schrödinger shall pay to
Columbia royalties calculated as set forth in this Section 5. In addition, Schrödinger shall pay Columbia the sum of $[**] payable in two equal installments of $[**] apiece, the first due within [**] of the Effective Date and the second
due no later than [**] after the Effective Date. 

  
 5 

 b.    Schrödinger shall pay to Columbia a “Software Product
Royalty” equal to the greater of: 
 (i)    [**]% (the “Floor Percentage”) multiplied by a fraction of
the Gross Revenues, calculated as follows: 
 [**]. 

Each [**] period following the Effective Date in which no University Improvements are delivered to Schrödinger shall constitute a “Floor Reduction
Period.” For each Floor Reduction Period, the Floor Percentage shall be reduced by [**] percent ([**]%) and such reduced Floor Percentage shall be used in all subsequent royalty calculations; provided, however, that the Floor Percentage shall
not be reduced below [**]%. For the avoidance of doubt, no Floor Reduction Period may overlap with another Floor Reduction Period. 

c.    In the event Schrödinger enters into a Services Agreement, for each Software Product used in connection with
such Services Agreement, for each year in which such Software Product is used for any amount of time in connection with such Services Agreement Schrödinger will pay to Columbia a Services Agreement Royalty equal to the product obtained by
multiplying: 
 (a)    the greater of: 

(i)    the then-current Floor Percentage or 

(ii)    a percentage of Gross Revenues equal to the product obtained by [**]; 

For purposes hereof, “[**]” shall mean [**]. For purposes hereof, “[**]” shall mean [**]. 

“Schrödinger-Columbia Agreements” shall mean, collectively: (i) that certain Agreement, dated May 5, 1994, between Columbia and
Schrödinger, Inc., subsequently assigned to Schrödinger by Consent, dated March 27, 2002; (ii) that certain Agreement, dated July 15, 1998, between Columbia and Schrödinger, Inc., subsequently assigned to Schrödinger by
Consent, dated March 27, 2002; and (iii) that certain Agreement, dated September, 2001, between Columbia and Schrödinger, Inc., subsequently assigned to Schrödinger by Consent, dated March 27, 2002. 

d.    In the event Gross Revenues or Services Fees are paid to Schrödinger in the form of equity securities,
Schrödinger may (in Schrödinger’s sole discretion) pay the relevant Software Product Royalty or Services Agreement Royalty either in cash (such cash payment to equal the product obtained by multiplying (i) the fair market value
of the equity securities constituting such Gross Revenues or Services Fees by (ii) the percentage of the Gross Revenues or Services Fees owed by Schrödinger to Columbia hereunder as a Software Product Royalty or Services Agreement Royalty)
or, to the extent permitted by law, by transferring to Columbia a portion of the equity securities received by Schrödinger in payment of the Gross Revenues or Services Fees, such portion to equal the percentage of the Gross Revenues or Services
Fees owed by Schrödinger to Columbia hereunder as a Software Product Royalty or Services Agreement Royalty. 

  
 6 

 e.    Schrödinger and its Affiliates shall have no payment
obligations to UC with respect to the PLOP Code. Columbia shall be solely responsible for compensating UC in connection with the rights granted hereunder. 

f.    For the avoidance of doubt, no royalties shall be due hereunder with respect to any product that does not
incorporate the PLOP Code or the University Improvements. 
 6.    Confidentiality; Protection of Software Components
and Related Information. 
 a.    Schrödinger hereby acknowledges that the PLOP Code and University Improvements
(collectively, “University Confidential Information”) are proprietary and confidential and agrees to retain the University Confidential Information in confidence and not to disclose the University Confidential Information or any portion
thereof, to third parties, except insofar as permitted by, and for the purposes of and in accordance with the terms of, this Agreement, including without limitation the licensing of a Software Product to third parties and the sublicensing of the
licenses granted hereby. Schrödinger (i) will protect the University Confidential Information in the same manner that it protects its own confidential information; (ii) will permit access to the University Confidential Information
only to employees, officers, directors, agents and consultants (each, a “Representative”) of Schrödinger or its Affiliates having a need to know for the purposes authorized under this Agreement and will inform such Representatives who
will have access to University Confidential Information of the obligations of confidentiality under this Agreement; and (iii) will not duplicate all or any part of the University Confidential Information, except insofar as permitted by this
Agreement for the purposes authorized hereunder. 
 b.    These obligations of confidentiality are not applicable to any
materials of Columbia or UC if and to the extent that such materials: 
 (i)    are in the public domain through no
fault of Schrödinger; 
 (ii)    were known to Schrödinger prior to initial disclosure by the disclosing
party, whether such disclosure occurred before or after the effective date of this Agreement 
 (iii)    were disclosed
to Schrödinger by a third party not known by Schrödinger to be bound by any obligation of confidentiality or prohibition of disclosure; or 

(iv)    are required to be disclosed by law. 

c.    Any termination of this Agreement or the licenses granted hereunder shall not terminate Schrödinger’s
obligations of confidentiality under this Section. 

  
 7 

 7.    Reports and Payments. 

a.    On or before the last business day of [**] of each year of this Agreement, Schrödinger shall submit to Columbia
a written report (the “Payment Report”) stating with respect to the preceding calendar quarter, a calculation under Section 5 hereof of the amounts due to Columbia from Schrödinger making reference to amounts due for each release
of any Software Product covered by such Payment Report. Calendar days that have been counted as part of the Software Product Use Ratio in a previous calendar quarter shall not count as part of the Software Product Use Ratio in any other calendar
quarter. Schrödinger shall also advise Columbia of the number lines of code attributable to Columbia Code, UC Code, and Non-University Code. Should Schrödinger request assistance from Columbia and/or UC with respect to identifying Columbia
Code or UC Code, Columbia and UC shall use commercially reasonable efforts to cooperate with such request. 

b.    Simultaneously with the submission of each Payment Report, Schrödinger shall make payment to Columbia of the
amounts due for the calendar quarter covered by the Payment Report. 
 c.    Schrödinger shall maintain at its
offices customary books of account and records showing its actions under this Agreement. Upon reasonable notice, such books and records shall be open to inspection and copying, at Schrödinger’s offices, and at Columbia’s expense,
during usual business hours, by an independent certified public accountant or software expert selected by the Columbia to whom Schrödinger has no reasonable objection, for [**] after the calendar quarter to which they pertain, for purposes of
verifying the accuracy of the amounts paid by Schrödinger to Columbia under this Agreement. 
 8.    Use for
Research Purposes of Licenses Granted. Columbia and UC reserve the right to use the PLOP Code, University Improvements and Unassigned Improvements at Columbia and UC, respectively, for teaching and academic research purposes and to permit other
academic or not-for-profit research institutions to use same for teaching and non-profit research purposes. 

9.    Freedom of Publication. Nothing in this Agreement shall restrict the right of Columbia or UC or of their
faculty or students to publish, disseminate or otherwise disclose descriptions of the PLOP Code, University Improvements and Unassigned Improvements for non-profit scholarly purposes only or, in connection
therewith, to disclose pertinent illustrative portions of such PLOP Code, University Improvements or Unassigned Improvements. 

10.    Disclaimer of Warranties. 

a.    Columbia and UC disclaim any responsibility for the accuracy or correctness of the PLOP Code, University Improvements
or Unassigned Improvements or for their use or application by Schrödinger or by any Affiliate, licensee or sub-licensee of Schrödinger. 

  
 8 

 b.    COLUMBIA AND UC MAKE NO REPRESENTATION OR WARRANTY, EITHER EXPRESS
OR IMPLIED OF ANY KIND, INCLUDING AS TO MERCHANTABILITY OR TO THE ADEQUACY OR SUITABILITY OF THE PLOP CODE, UNIVERSITY IMPROVEMENTS OR UNASSIGNED IMPROVEMENTS FOR ANY PARTICULAR PURPOSE OR TO PRODUCE ANY PARTICULAR RESULT, EXCEPT AS EXPRESSLY STATED
IN SECTION 2.c. HEREOF. EXCEPT FOR COLUMBIA’S OR UC’S GROSS NEGLIGENCE OR WILLFUL MISCONDUCT, NEITHER COLUMBIA NOR UC, NOR ANY EMPLOYEE NOR AGENT OF COLUMBIA OR UC, SHALL HAVE ANY LIABILITY TO SCHRÖDINGER OR ANY AFFILIATE, LICENSEE OR
SUB-LICENSEE OF SCHRÖDINGER OR TO ANY OTHER PERSON ARISING OUT OF THE USE OF THE PLOP CODE OR UNIVERSITY IMPROVEMENTS, WHETHER ALONE OR AS INCORPORATED IN A SOFTWARE PRODUCT, BY SCHRÖDINGER OR ANY AFFILIATE, LICENSEE OR SUB-LICENSEE OF SCHRÖDINGER OR ANY OTHER PARTY FOR ANY REASON, INCLUDING BUT NOT LIMITED TO THE LACK OF MERCHANTABILITY OR INADEQUACY OR UNSUITABILITY OF THE PLOP CODE, OR UNIVERSITY IMPROVEMENTS FOR ANY
PARTICULAR PURPOSE OR TO PRODUCE ANY PARTICULAR RESULT, OR FOR ANY LATENT DEFECTS THEREIN, OR FOR THE FAILURE OF COLUMBIA OR THE REGENTS TO PROVIDE SCHRÖDINGER OR ANY AFFILIATE, LICENSEE OR SUB-LICENSEE
OF SCHRÖDINGER OR ANY OTHER PERSON ANY CORRECTIONS IN THE PLOP CODE OR UNIVERSITY IMPROVEMENTS. 
 c.    In no
event will Columbia or UC or their respective trustees, officers, directors, agents, or employees, be liable to Schrödinger, any Affiliate, licensee or sublicense of Schrödinger, or any other party, for any loss or damages, consequential
or otherwise, including, but not limited to, time, money or good will, arising from this Agreement or from the use or operation of the PLOP Code or University Improvements. 

11.    Indemnity. Schrödinger shall hold harmless, defend and indemnify Columbia and UC and their respective
trustees, officers, agents, authors, sponsors of the research, and employees, from and against any damages, suits, claims, liabilities, costs and expenses (including reasonable attorneys’ fees actually incurred) based on the actions of
Schrödinger arising out of this Agreement, including without limitation, the manufacture, packaging, marketing, use, sale, rental or lease of the PLOP Code or University Improvements by Schrödinger, its Affiliates, or its (or their)
licensees or sub-licensees. Notwithstanding the foregoing, Schrödinger’s indemnity obligations hereunder will not apply to damages, suits, claims, liabilities, costs and expenses to the extent
arising as a result of the actions of Columbia or UC or their respective trustees, officers, directors, agents, sponsors, employees or consultants. 

12.    Insurance. 

a.    During the term of this Agreement and for a period of [**] following its termination, Schrödinger shall maintain
comprehensive general liability insurance on a claims made basis, including product liability insurance, with reputable and financially secure insurance carriers reasonably acceptable to Columbia to cover the activities of Schrödinger, its
Affiliates and its sublicensees, for minimum limits of $[**] combined single limit for bodily injury and property damage per occurrence and in the aggregate. Such insurance shall include Columbia and UC, their trustees, directors, officers,
employees, and agents as additional insureds. Schrödinger shall furnish a certificate of insurance evidencing such coverage, with [**] written notice to Columbia of cancellation or material change. 

b.    Schrödinger’s insurance shall be primary coverage; any insurance Columbia or UC may purchase shall be
excess and noncontributory. 

  
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 c.    Schrödinger shall at all times comply with all statutory
workers’ compensation and employers liability requirements covering its employees with respect to activities performed under this Agreement. 

13.    Use of Name. Schrödinger will not use the name of Columbia University or UC (or any campus of Columbia
or UC) for any purpose whatever without Columbia’s or UC’s written consent, as the case may be. The name of any faculty member, other employee or student of Columbia University or UC will not be used by Schrödinger without the written
consent of such person. 
 14.    Product Release. Schrödinger will use commercially reasonable efforts to
release a Software Product within [**] following the execution date of this Agreement. If Schrödinger fails to do so, Columbia, in its sole discretion, may elect to convert the exclusive licenses set forth in Section 2 into non-exclusive licenses. In the event that Columbia elects to convert the exclusive licenses into non-exclusive licenses (each, a “Converted License”) pursuant to the
foregoing sentence, should Schrödinger subsequently release a Software Product, the Converted Licenses shall automatically be converted into exclusive licenses, provided that no agreement or active negotiation between Columbia and any third
party for the licensing of the PLOP Code is then in effect or taking place. 
 15.    Termination. 

a.    This Agreement shall be effective as of the Effective Date and its provisions shall continue until their expiration
or termination in accordance with this Section 15. 
 b.    Columbia may terminate this Agreement and the licenses
granted hereunder upon [**] written notice of Schrödinger’s material breach of the Agreement and Schrödinger’s failure to cure the specified breach within [**] of receipt of said notice. Schrödinger may terminate this
Agreement upon [**] written notice of Columbia’s material breach of the Agreement and Columbia’s failure to cure the specified breach within [**] of receipt of said notice. 

c.    The following provisions shall survive termination of this Agreement: Sections 5, 6, 7, 11, 12, and 15; provided,
however, that if Schrödinger terminates this Agreement pursuant to Section 15.b, Section 5 shall not survive termination of this Agreement. 

d.    Upon termination of this Agreement, the licenses granted under Section 2 hereof shall be revoked and
Schrödinger shall thereafter be prohibited from using the PLOP Code or University Improvements as part of any Software Product and from marketing the PLOP Code or University Improvements as part of any Software Product; provided, however, that
within [**] after termination, Schrödinger shall deliver to Columbia a statement indicating the number and description of any Software Product(s) which it has on hand or is in the process of manufacturing as of the termination date.
Schrödinger may dispose of the Software Product(s) covered by this Agreement for a period of [**] after termination or expiration except that Schrödinger shall have no such right in the event this Agreement is terminated by Columbia
pursuant to section 15.b. above. Upon termination of this Agreement, at the request of any licensee of Schrödinger under a license or sub-license in effect as of such termination, Columbia shall, absent
unusual circumstances, grant directly to such licensee a license to use the PLOP Code and University Improvements incorporated in the Software Product licensed by Schrödinger to such licensee, on the same terms and conditions concerning such
use as those embodied in the then-existing license between Schrödinger and its licensee except for service, installation, support and maintenance. 

  
 10 

 e.    Notwithstanding anything in this Agreement to the contrary,
Schrödinger’s obligation to pay Software Product Royalties and Services Agreement Royalties shall terminate 20 years following the Effective Date. 

f.    Notwithstanding anything in this Agreement to the contrary, following any termination of this Agreement, to the
extent Schrödinger has licensed, without any right to further sublicense, Software Products to third parties pursuant to the rights granted in Section 2 herein, (i) such third parties shall retain perpetually the right to use such
Software Products as delivered by Schrödinger (notwithstanding the termination of this Agreement), (ii) Schrödinger shall have a perpetual right to continue providing support to such third parties in connection with their use of such
Software Products (notwithstanding the termination of this Agreement), and (ii) Schrödinger may, upon Columbia’s approval (which shall not be unreasonably withheld or delayed) use the PLOP Code to provide services pursuant to a
Services Agreement entered into prior to the effective date of termination. 
 16.    Copyright Fees. Within [**]
following the Effective Date, Columbia shall apply for, and during the term of this Agreement shall diligently pursue, a United States copyright registration for the PLOP Code and University Improvements. As exclusive licensee, Schrödinger
shall pay all reasonable copyright registration and attorney fees for counsel to which Schrödinger has no reasonable objection in connection with obtaining the foregoing copyright registration. 

17.    General Provisions. 

a.    Notice. Any notice or other communication required or permitted to be given under this Agreement must be in
writing and shall be considered given when mailed by certified or registered mail, return receipt requested, to the parties at the following addresses (or at such other address that a party may specify by notice hereunder): 

 

			
	If to Columbia:	  	Dr. Michael Cleare 
Executive Director 
Columbia Innovation Enterprise 
Science and Technology Ventures 
Columbia University 
Engineering Terrace, Ste 363

500 West 120th Street 
New York, New York 10027
		
	with a copy to:	  	Office of the General Counsel 
Columbia University 
412 Low Memorial Library 
New York, New York 10027
		
	If to Schrödinger:	  	Mr. Charles Ardai 
President 
Schrödinger, L.L.C. 
120 West 45th Street, 32nd Floor 
New York, NY
10036
		
	with a copy to:	  	Corporate Counsel 
Schrödinger, L.L.C. 
120 West 45th Street, 32nd Floor 
New York, NY 10036

  
 11 

 b.    Assignment. This Agreement and the licenses granted
hereunder shall be assignable by Schrödinger to (i) an Affiliate of Schrödinger, or (i) an entity in connection with a reorganization, merger, consolidation, acquisition, or other restructuring involving all or substantially all
of the voting securities and/or assets of Schrödinger. Except as otherwise set forth in the foregoing sentence, this Agreement and the licenses granted hereunder may not be assigned or transferred without the prior written consent of Columbia,
which shall not be unreasonably withheld or delayed beyond [**] after submission to Columbia of a request for such consent, provided that in connection with such a request, the name of the proposed assignee and such additional information relating
to the proposed assignee as Columbia may reasonably request shall also be submitted. 
 c.    Governing Law. This
Agreement shall be governed by New York law applicable to agreements made and to be performed in New York. The exclusive venue for any action relating to this Agreement shall be a state or federal court located in New York County, New York (and any
appellate court thereto). Each party expressly consents to the jurisdiction and venue of each state and federal court located in New York County, New York in connection with any such action. 

d.    Entire Agreement; Amendment. This Agreement sets forth the entire agreement between the parties concerning
the subject matter hereof and supersedes all previous agreements concerning the subject matter hereof, whether written or oral. This Agreement may be amended only by an instrument in writing duly executed on behalf of both parties. 

e.    No Waiver. Failure by either party hereto to enforce at any time or for any period of time any provision or
right hereunder shall not constitute a waiver of such provision or of the right of such party thereafter to enforce each and every such provision. 

f.    Force Majeure. Neither party shall be deemed in default hereunder, nor shall it hold the other party
responsible for, any cessation, interruption or delay in the performance of its obligations hereunder due to earthquake, flood, fire, storm, natural disaster, act of God, war, act of terrorism, armed conflict, labor strike, lockout, or boycott,
provided that the party relying upon this section (i) shall have given the other party written notice thereof promptly and, in any event, within [**] of discovery thereof and (ii) shall take all steps reasonably necessary under the
circumstances to mitigate the effects of the force majeure event upon which such notice is based. 

  
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 g.    Severability. If any provision hereof shall for any reason
be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions hereof, and such provision shall be construed to the maximum extent permissible so as to effect
the intent of the parties, and the validity, legality and enforceability of the remaining provisions of this Agreement shall not in any way be affected or impaired thereby. 

h.    Counterparts. This Agreement may be executed in one or more counterpart copies, each of which shall be deemed
to be an original and all of which shall together be deemed to constitute one Agreement. 
 IN WITNESS WHEREOF, the parties hereto have duly
executed this Agreement as of the day and year first above written. 
  

			
	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY NEW YORK
		
	By:	 	 /s/ Michael Cleare

		 	Dr. Michael Cleare, Executive Director
		 	Columbia Innovation Enterprise
	
	SCHRÖDINGER, L.L.C.
		
	By:	 	 /s/ Charles Ardai

		 	Mr. Charles Ardai, President

  
 13EX-10.28

 Exhibit 10.28 

EXECUTED VERSION 
 CONFIDENTIAL 

Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) would likely cause
competitive harm to the Company, if publicly disclosed. Double asterisks denote omissions. 
 SOFTWARE AND PATENT LICENSE AGREEMENT

 This SOFTWARE AND PATENT LICENSE AGREEMENT, dated May 27, 2008 (the “Effective Date”), is made by and
between THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, a New York corporation (“Columbia”), and SCHRÖDINGER, LLC (“Schrödinger”), a Delaware limited liability company. 

R E C I T A L S 

A.    The water site analysis method, developed at Columbia University by Professors Richard Friesner and Robert Abel, is
a method for enumerating the thermodynamic properties of water molecules solvating the active site of a protein and calculating the relative binding affinities of congeneric compounds that bind to such protein. Columbia is the owner of the water
site analysis method. 
 B.    Schrödinger is interested in incorporating the water site analysis method into its
software products. 
 C.    In accordance with the terms and conditions of this Agreement, Columbia wishes to grant to
Schrödinger, and Schrödinger wishes to receive from Columbia, the rights necessary for Schrödinger to develop, make, license, use, sell and distribute software products worldwide that incorporate and use the water site analysis
method. 
 NOW, THEREFORE, the parties agree as follows: 

1.    Definitions. In addition to the other terms defined throughout this Agreement, the following terms used in
this Agreement will have the following meanings: 
 a.    “Affiliate” shall mean any entity controlled
by, controlling, or under common control with a party, where “control” means the ownership, directly or indirectly, of fifty percent (50%) or more of the voting powers of the shares entitled to vote for the election of such entity’s
directors or other governing authority. D. E. Shaw Research, LLC (which is Schrödinger’s managing member as of the date hereof) shall be considered an Affiliate of Schrödinger. 

b.    “Copyright Only Royalty Rate” shall mean the royalty rate for a country of manufacture or sale in
which the Licensed Product is not Covered By a Patent. The Copyright Only Royalty Rate shall be [**] percent ([**]%), unless otherwise revised pursuant to this Agreement. 

 c.    “Cover” or “Covered By” shall
mean, with respect to a particular product, that the act of making, using, licensing, offering to license, selling, or offering to sell such product, if done without Columbia’s authority, (i) would infringe at least one claim of either
(i) an issued patent that has not been held invalid or unenforceable by a court of competent jurisdiction in an unappealed or unappealable decision in the country in which such patent was issued, or (ii) a pending application that has not
been pending for more than [**] from the filing date of such application. 
 d.    “Documentation”
shall mean the written or electronic material relating to the water site analysis method. Any Documentation delivered to Schrödinger hereunder shall be listed in Exhibit A. 

e.    “End User” shall mean an entity that is party to a valid license agreement with Schrödinger to
use the Licensed Product (typically Schrödinger’s customers), as well as the individuals permitted under such agreement to use the Licensed Product (typically the customer’s employees, consultants and other agents). 

f.    “Field” shall mean the field of computational chemistry software and related services. 

g.    “Gross Revenues” shall mean all fees or other payments received by Schrödinger and Affiliates
of Schrödinger for licensing, selling, leasing, or renting any Licensed Product (as hereinafter defined); provided, however, that fees or other payments received by Schrödinger in connection with licensing, selling, leasing,
or renting any Licensed Product to Columbia shall not constitute Gross Revenues; and provided further that fees or other payments constituting Services Fees (as hereinafter defined) shall not constitute Gross Revenues. For clarity,
Gross Revenues does not include discounts actually given; amounts allowed or credited due to returns; excise, sales and use taxes, to the extent included in the amounts invoiced; and charges for transportation, insurance and delivery. 

In the event that one or more Licensed Products are sold together with other products (such sale a “Multiple Product Sale”)
for a single aggregate license fee (a “Multiple Product License Fee”), Gross Revenues shall mean the fraction of the Multiple Product License Fee attributable to the Licensed Product(s), as calculated by multiplying the Multiple
Product License Fee by a fraction whose numerator is the then-current aggregate list price of any Licensed Product(s ) included in the Multiple Product Sale and whose denominator is the then-current aggregate list price of all products included in
the Multiple Product Sale. 
 By way of example only and without limiting the foregoing, [**]. 

h.    “Intellectual Property Rights” shall mean intellectual property or proprietary rights, including
but not limited to copyright rights, patent rights, rights of priority, and trade secret rights, recognized in any jurisdiction in the world. 

i.    “Licensed Method” shall mean the following elements of the water site analysis method: Licensed
Software, Documentation, and Patents. 
 j.    “Licensed Product” shall mean any product (or component
thereof) which (1) contains, includes or incorporates all or any part of the Licensed Software, or (2) the discovery, development, manufacture, use, sale, offering for sale, importation, exportation, distribution, rental or lease of which
is Covered By a claim of a Patent. 

  
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 k.    “Licensed Software” shall mean the software that
implements the water site analysis method, in Source Code Form and Object Code Form. The Licensed Software is described in Exhibit 8 attached hereto. 

l.    “Object Code Form” shall mean computer programming code that is in binary form, and directly
executable by a computer. 
 m.    “Patent” or “Patents” shall mean all patent rights
covering the Licensed Software and Documentation, which patents and patent applications are listed in Exhibit C, including (i) all substitutions, continuations, divisions, renewals, and letters patent granted thereon; (ii) all
claims of continuations-in-part applications that claim priority to the United States patent applications listed in Exhibit C, but only where such claims are
directed to inventions disclosed in the manner provided in the first paragraph of 35 U.S.C. Section 112 in the United States patent applications listed in Exhibit C, and such claims in any patents issuing from such continuation-in-part applications; (iii) any and all foreign patent applications, foreign patents or related foreign patent documents that claim priority to the patents
and/or patent applications listed in Exhibit C; and (iv) all reissues, re-examinations and extensions thereof. 

n.    “Patent Inclusive Royalty Rate” shall mean the royalty rate for a country of manufacture or sale in
which the Licensed Product is Covered By a Patent. The Patent Inclusive Royalty Rate shall be [**] percent ([**]%), unless otherwise revised pursuant to this Agreement. 

o.    “Schrodinger Improvements” shall mean the modifications, improvements and corrections to the
Licensed Software developed by employees, agents or independent contractors of Schrödinger or its Affiliates. 

p.    “Services Agreement” shall mean an agreement between Schrödinger (or its Affiliate), on the
one hand, and one or more third parties, on the other, under which Schrödinger (or its Affiliate) undertakes to perform services using a Licensed Product on behalf of, or in collaboration with, such third parties in return for fees or other
payments (any such fees or payments, “Services Fees”); provided, however, that fees or other payments received by Schrödinger (or its Affiliate) in connection with a Services Agreement with Columbia, shall not constitute
Services Fees; and provided further that fees or other payments constituting Gross Revenues shall not constitute Services Fees. 

q.    “Source Code Form” shall mean computer programming code other than in Object Code Form. Source Code
Form includes code that may be displayed in a form readable and understandable by a programmer of ordinary skill, as well as any enhancements, corrections and documentation related thereto, and all related source code level system documentation,
comments, procedural code (such as job control language), and explanatory materials. 

  
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 r.    “Territory” shall mean worldwide. 

s.    “Third Party” shall mean any entity or person other than Schrödinger, its Affiliates, or
Columbia. 
 2.    License Grants. 

a.    Copyright and Patent. Columbia hereby grants to Schrödinger and its Affiliates, upon and subject to all
the terms and conditions of this Agreement, a worldwide license, exclusive in the Field: 
 (1)    To
reproduce, modify, distribute, and perform and display, publicly or otherwise, the Licensed Software in connection with: 

(A)    Developing, marketing, licensing, selling and distributing the Licensed Product, Licensed Software
and/or Documentation in the Field and throughout the Territory; provided, however, that with respect to distribution, only the Object Code Form of the Licensed Software may be distributed to End Users; further provided
that, should Schrödinger desire to distribute the Source Code Form of any portion of the Licensed Software to an End User (such a transaction, a “SDA Source Code Transaction”), Schrödinger shall give Columbia written
notice (containing a reasonable summary of terms) thereof and obtain Columbia’s written approval therefor, which approval shall not be unreasonably withheld or delayed; and further provided that, should Schrödinger fail to
receive a written response from Columbia (containing reasonable detail regarding Columbia’s reason for denying such request, if such written response consists of a denial of approval) within [**] following Schrödinger’s delivery of
the foregoing notice, the SDA Source Code Transaction will be deemed approved; and further provided that Schrödinger shall be permitted to provide the Licensed Software in Source Code Form to those of its agents and independent
contractors retained to develop and maintain the Licensed Products, it being understood that the SDA Source Code Transaction procedures would not apply in this instance, so long as access and use by such agents and independent contractors are
subject to confidentiality obligations, and Columbia is informed, in the next following royalty report, of the identity of each such agent or independent contractor; 

(B)    Performing services pursuant to any Services Agreement; provided, however, that
notwithstanding the language in this Agreement, Licensee shall not be authorized to use the Licensed Software in connection with any Services Agreement until the Parties negotiate in good faith the royalty for Services Fees or other consideration to
be paid to Columbia, which shall be executed by the parties as an amendment to this Agreement; 

(C)    Conducting scientific or technical research; and 

(D)    Back-up and disaster recovery; and 

  
 4 

 (2)    To make, have made, use, license and sell the
Licensed Products and to practice the Patents to the end of their term, unless sooner terminated according to the terms hereof. 

b.    U.S. Government Agencies. If the End User is an agency of the United States government, Schrödinger
shall grant such agency only “restricted rights” or “ limited rights” (as defined in the applicable Federal Acquisition Regulations) to the Licensed Software, and Schrödinger shall take all actions reasonably necessary to
protect Columbia’s rights and interest in the Licensed Software in accordance with such regulations and successor regulations including, but not limited to, the placement of appropriate legends on the Licensed Software distributed by
Schrödinger. 
 c.    Government Rights. All rights and licenses granted by Columbia to Schrödinger and
its Affiliates under this Agreement are subject to ( i) any limitations imposed by the terms of any government grant, government contract or government cooperative agreement applicable to the technology that is the subject of this Agreement, and/or
(ii) applicable requirements of 35 U.S.C. Sections 200 et seq., as amended, and implementing regulations and policies. Without limitation of the foregoing, Schrödinger agrees that, to the extent required under 35 U.S.C.
Section 204, any Licensed Product used, sold, distributed, rented or leased by Schrödinger and its Affiliates in the United States will be manufactured substantially in the United States. In addition, Schrödinger agrees that, to the
extent required under 35 U.S.C. Section 202(c)(4), the United States government is granted a nonexclusive, nontransferable, irrevocable, paid-up license to practice or have practiced for or on behalf of
the United States any Patent throughout the world. 
 d.    All rights not specifically granted herein are reserved to
Columbia. Except as expressly provided by this Agreement, no right or license is granted (expressly or by implication or estoppel) by Columbia to Schrödinger or its Affiliates under any tangible or Intellectual Property Rights. 

3.    Ownership. 

a.    Columbia Property. The parties acknowledge and agree that (1) Columbia owns and shall own all right,
title and interest in and to the Licensed Method, and its associated Intellectual Property Rights (collectively, the “Columbia Property”); and (ii) other than the licenses expressly granted by this Agreement, Schrödinger
shall not receive or claim any ownership interest in any Columbia Property or portion thereof. 

b.    Schrödinger Property. The parties acknowledge and agree that as between Columbia and Schrödinger,
Schrödinger owns and shall own all right, title and interest in and to the Licensed Products and Schrödinger Improvements, and their associated Intellectual Property Rights (“Schrödinger Property”). 

  
 5 

 c.    Security. Schrödinger shall take all reasonable steps
to ensure that no unauthorized persons have access to the Licensed Software, and to ensure that no persons authorized to have such access shall take any action which would be in violation of this Agreement. Such steps shall include, but not be
limited to, imposing password restrictions on use of the Licensed Software, seaming Schrödinger’s network on which such Licensed Software resides from outside intrusion, preventing the making of unauthorized copies of the Licensed
Software, and administering and monitoring use of the Licensed Software. 
 d.    Reporting. Schrödinger
shall promptly report to Columbia any actual or suspected violation of this Section 3, and shall take such further steps as may reasonably be requested by Columbia to prevent or remedy any such violation. 

e.    Relief. Schrödinger agrees and acknowledges that the Licensed Method contains proprietary information of
Columbia that has been developed with great effort by its investigators, researchers and/or employees. Because unauthorized use or transfer of the Licensed Method is likely to diminish substantially its value, irreparably harm Columbia and not he
susceptible to cure by the payment of monetary damages, if Schrödinger breaches the provisions of Sections 2 or 3 of this Agreement, Columbia shall be entitled to injunctive and/or other equitable relief, in addition to other remedies afforded
by law, to prevent or restrain a breach of Sections 2 or 3 of this Agreement. 
 4.    No Maintenance. It is
understood that Columbia will provide no maintenance or installation services of any kind hereunder. Columbia may, in their sole discretion, use reasonable efforts to assist Schrödinger in correcting errors in the Licensed Software brought to
Columbia’s attention by Schrödinger; provided, however, that Columbia will not be considered in breach of this Agreement if it either is unable to do so after reasonable efforts or elects not to do so. 

5.    Licensing of Software by Schrödinger. Schrödinger shall cause its agreements with End Users to
license or maintain a Licensed Product to include the following: 
 a.    A provision for the protection of the
confidentiality of the Licensed Software provided to the licensee, by requiring protections of at least the same scope as required under Section 10 hereof; it being understood that this obligation shall be satisfied by prohibiting the
disclosure of the Licensed Products to non-licensees; 
 b.    A disclaimer that
is substantially equivalent to that set forth in subsections a , b. and c. of Section 12 hereof; and 
 c.    A
statement that Columbia shall not be required pursuant to such agreement to provide any maintenance or installation or support services of any kind, whatsoever. 

Columbia agrees that the standard Schrödinger End User License Agreement that is in effect on the effective date, a copy of which is attached hereto as
Exhibit D, complies with the requirements of this Section 5. Schrödinger agrees that the term of such End User License Agreements for the licensing of the Licensed Product shall not be perpetual. 

  
 6 

 6.    Reservation of Rights for Research Purposes; Freedom of
Publication. 
 a.    Columbia reserves the right to practice and use the Patents, Licensed Software and
Documentation for academic research and non-commercial educational purposes in the Field and to permit other entities or individuals to practice and use such Patents, Licensed Software and Documentation for
academic research and non-commercial educational purposes in the Field. Columbia shall obtain from all entities or individuals who are given permission to practice and use such Patents, Licensed Software and
Documentation an agreement in writing to limit such use to academic research and non-commercial educational purposes and shall inform Schrödinger of the identity of all such entities and individuals.
Nothing in this Agreement shall be interpreted to limit in any way the right of Columbia and its faculty or employees to practice and use such Patents, Licensed Software or Documentation for any purpose outside the Field or to license or permit such
use outside the Field by third parties. 
 b.    Schrödinger acknowledges that Columbia is dedicated to free
scholarly exchange and to public dissemination of the results of its scholarly activities. Columbia and its faculty and employees shall have the right to publish, disseminate or otherwise disclose any information relating to its research activities,
including Licensed Software. 
 7.    Fees, Royalties and Payment. 

a.    License Fee. Schrödinger shall pay Columbia a nonrefundable, and
non-recoverable license fee in the sum of $[**], to be paid as follows: $[**] within [**] following the full execution of this Agreement, and the balance by [**]. 

b.    Licensed Product Royalties. 

(1)    Licensed Product Royalties. For licenses or sales by Schrödinger and its Affiliates to
End Users in the Territory, Columbia shall be entitled to receive a nonrefundable and non-recoverable royalty equal to, with respect to the license or sale of each Licensed Product, the sum of (i) the
applicable Patent Inclusive Royalty Rate multiplied by tile Gross Revenues generated in countries of manufacture or sale in which the Licensed Product is Covered By a Patent, plus (ii) the applicable Copyright Only Royalty Rate multiplied by
the Gross Revenues generated in countries of manufacture or sale in which the Licensed Product is not Covered By a Patent ((i) and (ii) together, the “Licensed Product Royalty”). See definition of “Gross Revenues” for
the calculation applicable to Multiple Product Sales. In pricing Multiple Product Sales, Schrödinger shall not engage in bad faith actions intended to avoid its obligations under this Section 7. 

(2)    [Intentionally left blank.] 

(3)    Multiple Royalties. If there are two royalties payable by Schrödinger to Columbia in
connection with a particular Licensed Product, then Schrödinger shall be responsible for payment of only one royalty based on Gross Revenues, such royalty to be equal to the highest of the two applicable royalties. If there are more than two
royalties payable by Schrödinger to Columbia in connection with a particular Licensed Product, then the Parties shall negotiate in good faith the single royalty applicable to such Licensed Product. 

  
 7 

 c.    Equity Securities. In the event that all or any portion of
Gross Revenues or Services Fees are received by Schrödinger from a customer in the form of equity securities, Schrödinger may, in its sole discretion, remit the applicable Licensed Product Royalty to Columbia in any combination of cash or,
to the extent transfer is permitted by law, a portion of the equity securities received. For purposes of calculating Gross Revenues or Service Fees, the value of the equity securities received shall be equal to the fair market value of such
securities. 
 d.    Non-Monetary Consideration. Where Licensed
Product(s) are not licensed for a fee, but are otherwise disposed of and used by a third party, such disposal shall be deemed, for purposes of calculating royalties, a sale or license generating Gross Revenues equal to the published list price for
such Licensed Product(s). Instances in which a royalty is paid under this provision will be identified in the applicable royalty report. For clarity, the evaluation licenses granted free of charge by Schrödinger for short terms (i.e., a few
months’ duration) in the ordinary course of business to prospective licensees of the Licensed Product(s) shall be excluded from royalty payments under this provision. 

e.    Royalty Rate Adjustment on Challenge. 

(1)    In the event Schrödinger (or any entity or person acting on its behalf) initiates any
proceeding or otherwise asserts any claim challenging the validity or enforceability of any Patent in any court, administrative agency or other forum (“Challenge”), all royalty rates, minimum royalties and other payment rates set
forth in Section 7.b., shall be automatically [**] on sales of Licensed Products on or after the date of the Challenge for the remaining term of this Agreement. The parties acknowledge that this Section 7.e. shall not apply to the
situation in which Schrödinger is alleged by Columbia to have exceeded the scope of the rights licensed under this Agreement, and raises challenges to the validity, enforceability or scope of such Patent in its defense. 

(2)    In the event at least one claim of a Patent that is subject to a Challenge survives the Challenge by
not being found invalid or unenforceable, regardless of whether the claim is amended as part of the Challenge, all royalty rates and other payment rates set forth in Section 7.b. shall be automatically [**] on and after the date of such finding
for the remaining term of this Agreement. 
 (3)    Schrödinger acknowledges and agrees that any
payments made under this Section 7.e. shall be nonrefundable and non-recoverable for any reason whatsoever. 

8.    Reports and Payments. 

a.    Within [**] after the first business day of each calendar quarter of this Agreement, Schrödinger shall submit to
Columbia a written report with respect to the preceding calendar quarter (the “Payment Report”) stating: 

(1)    Gross Revenues received by Schrödinger during such quarter, together with detailed information
sufficient to permit Columbia to verify the accuracy of reported Gross Revenues, including Licensed Product name, date of transaction, name of customer, license fee, and offsets taken against Gross Revenues; 

  
 8 

 (2)    Services Fees received by Schrödinger during
such quarter, together with detailed information sufficient to permit Columbia to verify the accuracy or reported Services Fees; 

(3)    A calculation under Section 7 of the Licensed Product Royalties and Services Royalties due to
Columbia, making reference to the applicable subsection thereof; 
 (4)    Pursuant to the last
“provided further” clause of Section 2.a.(1)(A), the identity of each agent or independent contractor who, during the preceding calendar quarter, was first given access to the Licensed Software in Source Code Form; and 

(5)    The list of the licenses to the Licensed Product(s) granted for
non-monetary consideration in the preceding calendar quarter, for which a royalty has been calculated in accordance with Section 7.d. 

b.    Simultaneously with the submission of each Payment Report, Schrödinger shall make payments to Columbia of the
amounts due for the calendar quarter covered by the Payment Report in the manner specified by Columbia. Payment shall be by check payable to The Trustees or Columbia University in the City of New York and sent to the following address: 

The Trustees of Columbia University in the City of New York 

Columbia Innovation Enterprises – Finance 

P.O. Box 1394 
 New York, NY
10008-1394 
 and in the event that such royalty report lists the identities of individuals in accordance with Section 8.a.(4), a copy shall be sent to
the following address: 
 Executive Director 

Science and Technology Ventures 

80 Claremont Avenue #4F, MC 9606 

New York, NY 10027 
 or to such other address as
Columbia may specify by notice hereunder, or, if requested by Columbia, by wire transfer of immediately available funds by Schrödinger to: 

[**] 
 or to such other bank and account
identified by notice to Schrödinger by Columbia. Schrödinger is required to send the quarterly royalty statement whether or not royalty payments are due. 

  
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 c.    Within [**] after the date of termination or expiration of this
Agreement, Schrödinger shall pay Columbia any and all amounts that are due pursuant to this Agreement as of the date of such termination or expiration, together with a Payment Report for such payment in accordance with Section 8.a. hereof,
except that such Payment Report shall cover the period from the end of the last calendar quarter prior to termination or expiration to the date of termination or expiration. Nothing in the foregoing shall be deemed to satisfy any of
Schrödinger’s other obligations under this Agreement upon termination or expiration. 
 d.    With respect to
revenues obtained by Schrödinger in foreign countries, Schrödinger shall make royalty payments to Columbia in the United States in United States dollars. Royalty payments for transactions outside the United States shall first be determined
in the currency of the country in which they are earned, and then converted to United States dollars using the buying rates of exchange quoted by Citibank, N.A. (or its successor) in New York, New York for the last business day of the calendar
quarter in which the royalties were earned. Any and all loss of exchange value, taxes, or other expenses incurred in the transfer or conversion of foreign currency into U.S. dollars, and any income, remittance, or other taxes on such royalties
required to be withheld at the source shall be the exclusive responsibility of Schrödinger, and shall not be used to decrease the amount of royalties due to Columbia. None of the foregoing prohibited deductions shall be construed to be a
permissible deduction within the definition of offsets. Royalty statements shall show sales and licenses both in the local currency and US dollars, with the exchange rate used clearly stated. 

e.    Schrödinger shall maintain at its Portland, Oregon office usual books of account and records showing its
actions under this Agreement, and sufficient to determine Schrödinger’s compliance with its obligations hereunder. Upon reasonable notice, but not more than [**], Columbia may have an independent certified public accountant or independent
auditor, and an attorney (each acceptable to Schrödinger in its reasonable judgment) inspect and copy such books and records for purposes of verifying the accuracy of the amounts paid under this Agreement. The review may cover a period of not
more than [**] before the first day of the calendar quarter in which the review is requested. In the event that such review shows that Schrödinger has underpaid royalties by [**] percent ([**]%) or more of the aggregate amount that should have
been paid to Columbia for a [**] period ([**]) in a calendar year, but not less than $[**], Schrödinger shall pay, within [**] after demand by Columbia, the costs and expenses of such review (including the fees charged by Columbia’s
accountant and attorney involved in the review), in addition to the amount of any underpayment and any interest thereon. Schrödinger agrees to cooperate fully with Columbia’s accountant or auditor and attorney in connection with any such
review. During the review, Schrödinger shall provide Columbia’s accountant or auditor and attorney with all information reasonably requested, including without limitation, information relating to sales and licenses, inventory,
manufacturing, purchasing, transfer records, customer lists, invoices, purchase orders, sales orders, shipping documentation, third-party royalty reports, cost information, pricing policies, and agreements with third parties. 

f.    Notwithstanding anything to the contrary in this Agreement (including Section 16.b.), and without limiting any
of Columbia’s rights and remedies hereunder, any payment by Schrödinger required hereunder that is made late (including unpaid portions of amounts due) shall bear simple interest at the rate of [**]% per annum. Any interest charged or paid
in excess of the maximum rate permitted by applicable law shall be deemed the result of a mistake and interest paid in excess of the maximum rate shall be credited or refunded (at Schrödinger’s option) to Schrödinger. In addition,
Columbia shall promptly refund the amount of any overpayment by Schrödinger. 

  
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 g.    Schrödinger shall reimburse Columbia for any costs and
expenses incurred in connection with collecting on any arrears of Schrödinger with respect to its payment and reimbursement obligations under this Agreement (such as Section 15.b. of this Agreement), including the costs of engaging any
collection agency for such purpose. 
 h.    By [**] of each year of this Agreement, Schrödinger shall submit to
Columbia a non-binding forecast of the projected growth (or decline) of its gross licensing revenue generated from all software products (not limited to the Licensed Products) in the coming year, expressed as
a percentage of such revenue of the year just ended. Columbia shall use such forecasts solely in connection with its internal budgeting purposes. 

9.    Diligence. 

a.    Product Release. Schrödinger will use commercially reasonable efforts to release a Licensed Product
within [**] following the Effective Date. If Schrödinger fails to do so, Columbia, in its sole discretion, may elect to convert the exclusive licenses set forth in Section 2 into non-exclusive
licenses. In the event that Columbia elects to convert the exclusive licenses into non-exclusive licenses (each, a “Converted License”) pursuant to the foregoing sentence, should
Schrödinger subsequently release a Licensed Product, Schrödinger shall notify Columbia of such product release in writing and the Converted Licenses shall automatically be converted into exclusive licenses; provided that no
agreement between Columbia and a Third Party is then in effect, or if no agreement is then in effect, that Columbia is not in active negotiations with a Third Party for such an agreement. 

b.    Within [**] following receipt of a written request from Columbia, Schrödinger shall report in writing to
Columbia on progress made toward the release of a Licensed Product. 
 10.    Confidentiality. 

a.    Except to the extent required to discover, develop, manufacture, use, sell, have sold, distribute, rent or lease
Licensed Products in the Field, Schrödinger shall treat as confidential the Patents and the Licensed Software in Source Code Form disclosed hereunder, and shall not disclose or distribute the same to any Third Party, or use for any purpose,
without Columbia’s written permission. Except to the extent required to verify the payments made by Schrödinger hereunder, Columbia shall treat as confidential any information about Schrödinger’s sales, financial results,
customer, product pricing, product development, release dates, and marketing plans that may be disclosed to Columbia hereunder, and shall not disclose or distribute the same, or use for any purpose, without Schrödinger’s written
permission. 
 b.    The obligations of confidentiality under this Section 10 do not apply to any of disclosing
party’s confidential information that the receiving party can demonstrate: 
 (1)    Was known to
receiving party prior to receipt thereof from disclosing party; 

  
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 (2)    Was or becomes a matter of public information or
publicly available through no act or failure to act on the part of receiving party; 
 (3)    Is acquired
by receiving party from a Third Party entitled to disclose it to disclosing party; or 
 (4)    Receiving
party discovers, develops independently without reference to or use of disclosing party’s confidential information, as evidenced by contemporaneous written records. 

11.    Representations and Warranties. Columbia represents and warrants to Schrödinger that as of the
Effective Date and to the best knowledge of its office of Science and Technology Ventures (“STV”), all of the listed inventors on the Patents and the developers who have disclosed the Software to STV have assigned all of their rights and
interests to Columbia. 
 12.    Disclaimer of Warranty; Limitations of Liability. 

a.    EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT, COLUMBIA IS LICENSING THE LICENSED METHOD ON AN “AS IS”
BASIS, AND COLUMBIA (I) MAKES NO WARRANTIES EITHER EXPRESS OR IMPLIED OF ANY KIND, AND (II) HEREBY EXPRESSLY DISCLAIMS ANY WARRANTIES, REPRESENTATIONS OR GUARANTEES OF ANY KIND AS TO THE LICENSED METHOD, LICENSED PRODUCTS AND/OR ANYTHING
DISCOVERED, DEVELOPED, MANUFACTURED, USED, SOLD, OFFERED FOR SALE, IMPORTED, EXPORTED, DISTRIBUTED, RENTED, LEASED OR OTHERWISE DISPOSED OF UNDER ANY LICENSE GRANTED HEREUNDER, INCLUDING BUT NOT LIMITED TO: ANY WARRANTIES OF MERCHANTABILITY, TITLE,
FITNESS, ADEQUACY OR SUITABILITY FOR A PARTICULAR PURPOSE, USE OR RESULT; ANY WARRANTIES AS TO THE VALIDITY OF ANY PATENT; AND ANY WARRANTIES OF FREEDOM FROM INFRINGEMENT OF ANY DOMESTIC OR FOREIGN PATENTS, COPYRIGHTS, TRADE SECRETS OR OTHER
PROPRIETARY RIGHTS OF ANY PARTY. 
 b.    In no event shall Columbia, or its trustees, officers, faculty members,
students, employees and agents, have any liability to Schrödinger, its Affiliates, or any Third Party arising out of the use, operation or application of the Patents, Licensed Software, Licensed Products, or anything discovered, developed,
manufactured, used, sold, offered for sale, imported, exported, distributed, rented, leased or otherwise disposed of under any license granted hereunder by Schrödinger, its Affiliates, or any Third Party for any reason, including but not
limited to, the unmerchantability, inadequacy or unsuitability of the Patents, Licensed Software, Licensed Products and/or anything discovered, developed, manufactured, used, sold, offered for sale, imported, exported, distributed, rented, leased or
otherwise disposed of under any license granted hereunder for any particular purpose or to produce any particular result, or for any latent defects therein. 

  
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 c.    In no event will Columbia, or its trustees, officers, faculty
members, students, employees and agents, be liable to Schrödinger, its Affiliates or any other party for any consequential, incidental, special or indirect damages (including, but not limited to, from any destruction of property or from any
loss of use, data, revenue, profit, time or good will) based on activity arising out of or related to this Agreement, whether pursuant to a claim of breach of contract or any other claim of any type. In no event will Schrödinger, its
Affiliates, or their respective directors, officers, employees, consultants, advisors and agents, be liable to Columbia or any other party for any consequential, incidental, special or indirect damages (including, but not limited to, damages
resulting from any destruction of property or from any loss of use, data, revenue, profit, time or good will) based on activity arising out of or related to this Agreement, whether pursuant to a claim of breach of contract or any other claim of any
type. Other than for its obligations under Section 16, in no event shall Columbia’s liability to Schrödinger exceed the payments actually made to Columbia by Schrödinger under this Agreement. Other than for its obligations under
Section 16, in no event shall Schrödinger’s liability to Columbia exceed the payments actually made to Columbia by Schrödinger under this Agreement. 

d.    The parties hereto acknowledge that the limitations and exclusions of liability and disclaimers of warranty set
forth in this Agreement form an essential basis of the bargain between the parties. 
 13.    Prohibition Against Use
of Columbia’s Name. Except as otherwise provided herein, Schrödinger will not use the name, insignia, or symbols of Columbia, its faculties or departments, or any variation or combination thereof, or the name of any trustee, faculty
member, other employee, or student of Columbia for any purpose whatsoever without Columbia’s prior written consent. Columbia hereby consents to Schrödinger’s use of factual statements about the development of the Licensed Method,
including without limitation the fact that the key developers of the Licensed Method are Professors Richard Friesner and Robert Abel of Columbia University’s Chemistry Department. 

14.    Compliance with Governmental Obligations. 

a.    Notwithstanding any provision in this Agreement, Columbia disclaims any obligation or liability arising under the
license provisions of this Agreement if Schrödinger or any Affiliate is charged in a governmental action for not complying with or fails to comply with governmental regulations in the course of taking steps to bring any Licensed Product to a
point of practical application. 
 b.    Each party shall comply upon reasonable notice from the other party with all
governmental requests directed to either Columbia or Schrödinger or its Affiliates, and provide all information and assistance necessary to comply with such governmental requests. Notwithstanding the foregoing, to the extent that information
responsive to a governmental request is confidential or proprietary to the disclosing party, the notifying party shall provide reasonable assistance to the disclosing party to secure confidential treatment for such disclosure. 

  
 13 

 c.    Schrödinger and its Affiliates shall ensure that research,
development, manufacturing and marketing under this Agreement complies with all government regulations in force and effect including, but not limited to, Federal, state, and municipal legislation. 

15.    Patent Prosecution and Maintenance; Infringement. 

a.    All Patents will be filed and maintained in Columbia’s name, in those jurisdictions specified by
Schrödinger. Columbia, by counsel it selects to whom Schrödinger has no reasonable objection, shall be responsible for preparing, filing, prosecuting and maintaining all Patents in Columbia’s name, and for consulting in a timely
manner with Schrödinger and its designated counsel regarding the foregoing. Specifically, Columbia agrees to use reasonable efforts (i) to immediately forward to Schrödinger copies of all correspondence from any governmental authority
with respect to the Patents; (ii) to consult with Schrödinger and its counsel, within a reasonable time period in advance of the applicable response deadline, regarding the content of Columbia’s response to such correspondence;
(iii) to provide Schrödinger and its counsel meaningful input throughout the process into the prosecution strategy for each Patent; and (iv) to communicate regular updates to Schrödinger and its counsel. The parties agree that
consultation between the parties relating to the Patents under this Section 15 shall be pursuant to a common interest in the validity and enforceability of the Patents. Schrödinger shall treat such consultation, along with any information
disclosed by Columbia in connection therewith (including any information concerning patent expenses), on a strictly confidential basis, and shall not disclose such consultation or information to any party without Columbia’s prior written
consent. If Schrödinger seeks to Challenge the validity or enforceability of any Patent, Columbia’s consultation obligation under this Section 15.a. shall automatically terminate; for the avoidance of doubt, any such termination shall
not affect Schrödinger’s confidentiality and nondisclosure obligations with respect to consultation or disclosure of information prior to such termination, and shall not affect any other provisions of this Agreement (including
Schrödinger’s reimbursement obligation under Section 15.b.). 
 b.    Schrödinger will reimburse
Columbia for the reasonable expenses that Columbia has incurred prior to the Effective Date and will pay the reasonable expenses that Columbia incurs following the Effective Date in preparing, filing, prosecuting and maintaining the Patents. For
avoidance of doubt, reimbursable expenses include reasonable attorneys’ fees, actual patent filing fees, issue fees, working fees, maintenance fees, renewal charges, annuities, costs of any interference proceedings, oppositions, reexamination,
and any other ex parte or inter partes administrative proceedings before patent offices. Columbia, using reasonable efforts, estimates that patent expenses incurred before the Effective Date under Section 15.a in connection with the Patents set
forth in Exhibit C are $[**], and shall be reimbursed in full by Schrödinger to Columbia within [**] of the later of (i) the Effective Date, and (ii) receipt by Schrödinger of reasonable documentation supporting the
expense. Patent expenses incurred by Columbia after such date shall be reimbursed to Columbia by Schrödinger within [**] of receiving an invoice and reasonable documentation from Columbia. 

  
 14 

 c.    In accordance with Section 15.a., Schrödinger may decide
to discontinue the prosecution in a jurisdiction of a filed Patent application, or the maintenance in a jurisdiction of an issued Patent. Provided that Schrödinger receives a written inquiry from Columbia at least [**] in advance of an
impending deadline, a failure by Schrödinger to respond to a written inquiry from Columbia [**] in advance of an impending deadline concerning the prosecution of a filed Patent application or the maintenance of an issued Patent shall be deemed
a decision not to prosecute or maintain, as the case may be. If Columbia objects to Schrödinger’s decision to discontinue such prosecution or maintenance, the parties shall promptly meet to resolve the difference in good faith. If the
difference cannot be resolved after diligent effort, Columbia shall have the right, upon written notice to Schrödinger, to continue such prosecution or maintenance at Columbia’s expense; provided that upon receipt of such written
notice, Schrödinger’s license to use the Licensed Method in the jurisdiction in question shall terminate. Notwithstanding the foregoing, in the event that Schrödinger is using the Licensed Method in the jurisdiction in question, upon
written request to Columbia, the parties shall discuss in good faith whether such license to Schrödinger should become non-exclusive for the Field. 

d.    Subject to Section 15.g., Columbia shall have the sole right to initiate, control, defend and/or settle any
proceedings involving the validity, enforceability or infringement of any Patents when in its sole judgment such action may be necessary, proper, and justified. As part of any settlement, Columbia is empowered to grant a sublicense to the Patents,
subject to Schrödinger’s exclusive rights in the Field, on terms Columbia determines in its sole judgment are necessary, proper, and justified. Notwithstanding the foregoing, Columbia agrees to communicate regular updates to
Schrödinger and its counsel regarding any such proceedings, and to notify Schrödinger promptly of the terms of any disposition or settlement of any such proceeding. 

e.    Upon written notice to Columbia, Schrödinger may request that Columbia take steps to stop a third party that is
developing, licensing or selling a product that does or will compete with a Licensed Product being developed, licensed or sold by Schrödinger or any of its Affiliates (“Third Party Infringer”) from infringing an issued patent
falling within the definition of Patents by providing Columbia with written evidence demonstrating prima facie infringement of specific claims of such Patent. Subject to Sections 15.e., 15.f. and 15.g., Schrödinger shall have the right to
initiate legal proceedings against any such Third Party Infringer in its own name and at Schrödinger’s sole expense, unless Columbia, not later than [**] after receipt of such notice (or in the case of a proceeding involving a request to
file a temporary restraining order, [**] after receipt of such notice by Columbia’s Office of the General Counsel), either (i) causes such infringement to cease or (ii) initiates legal proceedings against the Third Party Infringer.
Notwithstanding the foregoing, Columbia shall have no obligation to assert more than one Patent in one jurisdiction against the Third Party Infringer. Any proposed disposition or settlement of a legal proceeding filed by Schrödinger to enforce
any issued patent falling within the definition of Patents against any Third Party Infringer shall be subject to Columbia’s prior written approval, which approval shall not be unreasonably withheld or delayed. Notwithstanding the foregoing,
Schrödinger’s rights under this Section 15.e. shall apply only to claims of Patents that are exclusively licensed to Schrödinger under this Agreement and only in the Field and Territory which are exclusively licensed to
Schrödinger under this Agreement. 

  
 15 

 f.    Any recovery, whether by way of settlement or judgment, from a
third party pursuant to a legal proceeding initiated in accordance with Sections 15.d. or 15.e. shall first be used to reimburse the party initiating such legal proceedings for its actual fees, costs and expenses incurred in connection with such
proceeding. The balance of such recovery shall be divided [**] percent ([**]%) to the party that initiated the legal proceeding and [**] percent ([**]%) to the other party. 

g.    In the event a party initiates or defends a legal proceeding concerning any Patent pursuant to this Section 15,
the other party shall cooperate fully with and supply all assistance reasonably requested by the party initiating such proceeding, including without limitation, joining the proceeding as a party if requested. The party that institutes any legal
proceeding concerning any Patent pursuant to this Section 15 shall have sole control of that proceeding and shall reimburse the other party for any reasonable expenses incurred in providing assistance and cooperation in accordance with this
Section 15.g. 
 16.    Indemnity and Insurance. 

a.    Schrödinger will indemnify, defend, and hold harmless Columbia, its trustees, officers, faculty, employees,
students and agents, from and against any and all claims, actions, losses, damages, liability, costs and expenses, including, without limitation, reasonable attorneys’ fees and disbursements (collectively, “Losses”), incurred
by a Columbia indemnified party in any Third Party action arising out of (i) the discovery, development, manufacture, packaging, use, sale, offering for sale, importation, exportation, distribution, rental or lease of Licensed Products or
Licensed Software, even if altered for use for a purpose not intended; (ii) the use of Patents or Licensed Software by Schrödinger, its Affiliates or customers; (iii) any representation made or warranty given by Schrödinger or
its Affiliates to a Third Party with respect to Licensed Products, Patents or Licensed Software; (iv) any claims that a Licensed Product infringe a Third Party’s Intellectual Property Rights (but excluding any claim that the Licensed
Method infringes a Third Party’s Intellectual Property Rights); and (v) any asserted violation of the Export Laws (as defined in Section 18 hereof) by Schrödinger or its Affiliates. 

b.    Schrödinger’s indemnification obligations hereunder shall be subject to (1) receiving prompt written
notice by the Columbia indemnified party of the existence of any indemnifiable Loss or Third Party action, but any failure to so notify Schrödinger shall not relieve it from any liability that it may have to the Columbia indemnified party
except to the extent Schrödinger shall be materially prejudiced by such failure; (ii) being able, at its option, to control the defense of such Third Party action; (iii) permitting the Columbia indemnified party to participate in the
defense of a Third Party action at its own cost; and (iv) receiving full cooperation of the Columbia indemnified party in the defense thereof. Other than as otherwise provided herein, Schrödinger shall reimburse each Columbia indemnified
party for the expenses (including reasonable attorneys’ fees) incurred in enforcing this provision. 

  
 16 

 c.    Schrödinger shall maintain, during the term of this
Agreement, with reputable and financially secure insurance carriers reasonably acceptable to Columbia to cover the activities of Schrödinger and its Affiliates, (i) commercial general liability insurance (including product liability and
contractual liability insurance applicable to Schrödinger’s indemnity obligations under Section 16.a.), for minimum limits of $[**] combined single limit for bodily injury and property damage per occurrence and $[**] in the aggregate;
and (ii) umbrella liability insurance, for minimum limits of $[**] per event and $[**] in the aggregate. Such insurance shall include Columbia, its trustees, faculty, officers, employees and agents as additional insureds. Schrödinger shall
furnish a certificate of insurance evidencing such coverage, with [**] written notice to Columbia of cancellation or material change in coverage. The minimum amounts of insurance coverage required herein shall not be construed as creating any
limitation on Schrödinger’s indemnity obligation under Section 16.a. of this Agreement. 

d.    Schrödinger’s insurance shall be primary coverage; any insurance Columbia may purchase shall be excess and
noncontributory. Schrödinger’s insurance shall be written to cover claims incurred, discovered, manifested, or made during or after the expiration of this Agreement. 

e.    Schrödinger shall at all times comply with all statutory workers’ compensation and employers’
liability requirements covering its employees with respect to activities performed under this Agreement. 

17.    Marking. 

a.    Prior to the issuance of patents falling within the definition of Patents, Schrödinger shall mark all Licensed
Products made, sold, offered for sale, imported, or otherwise disposed of by Schrödinger under the license granted in this Agreement with the words “Patent Pending,” and following the issuance of one or more patents, with the numbers
of such patents. Schrödinger shall cause its Affiliates to comply with the marking requirements of this Section 17. 

b.    Schrödinger shall not alter or remove any printed or on-screen
copyright, trade secret, proprietary and/or other legal notices contained on or in copies of Licensed Software, and shall ensure that all on-line screens, logos, progress indicators or messages displayed by
the Licensed Software with respect to identification of Columbia shall be displayed in a similar fashion and location by the Licensed Products. 

18.    Export Control Laws. 

Schrödinger agrees to comply with U.S. export laws and regulations pertaining to the export of technical data, services and commodities,
including the International Traffic in Arms Regulations (22 C.F.R. § 120 et seq.), the Export Administration Regulations (15 C.F.R. § 730 et seq.), the regulations administered by the Treasury Department’s Office of Foreign Assets
Control (31 C.F.R. & 500, et seq.). and the Anti-Boycott Regulations (15 C.F.R. § 760) (collectively, the “Export Laws”). The parties shall cooperate with each other to facilitate compliance with these laws and regulations.

 Schrödinger understands that sharing controlled technical data with non-U.S. persons is an
export to that person’s country of citizenship that is subject to the Export Laws, even if the transfer occurs in the United States. Schrödinger shall obtain any necessary U.S. government license or other authorization required pursuant to
the Export Laws for the export or re-export of any commodity, service or technical data covered by this Agreement, including technical data acquired from Columbia pursuant to this Agreement and products
created as a result of that data. 

  
 17 

 19.    Breach and Cure. 

a.    In addition to applicable legal standards, Schrödinger shall be deemed to be in material breach of this
Agreement for: (i) failure to pay fully and promptly amounts due pursuant to Section 7 and payable pursuant to Section 8; (ii) failure of Schrödinger to meet any of its obligations under Section 10 of this Agreement;
(iii) failure to comply with governmental requests directed to Columbia or Schrödinger pursuant to Section 14(b); (iv) failure to reimburse Columbia for or pay fully and promptly the costs of prosecuting and maintaining Patents
pursuant to Section 15; (v) failure to obtain and maintain insurance in the amount and of the type provided for in Section 16; and (vi) failure to comply with the Export Laws under Section 18. 

b.    Either party shall have the right to cure its material breach. The cure shall be effected within a reasonable period
of time but in no event later than [**] after notice of any breach given by the non-breaching party. 

20.    Term of Agreement. 

a.    This Agreement shall be effective as of the Effective Date and shall continue in full force and effect until its
expiration or termination in accordance with this Section 20. 
 b.    The licenses granted under this Agreement
may be terminated by Columbia: (i) upon written notice to Schrödinger for Schrödinger’s material breach of the Agreement and Schrödinger’s failure to cure such material breach in accordance with Section 19.b.; (ii)
in the event that Schrödinger becomes the subject of a voluntary petition in bankruptcy or any voluntary proceeding relating to insolvency, receivership, liquidation, or composition for the benefit of creditors, and such petition or proceeding
is not dismissed within [**] of filing; (iii) in the event that Schrödinger becomes the subject of any involuntary petition in bankruptcy or any involuntary proceeding relating to insolvency, receivership, liquidation, or composition for
the benefit of creditors, and such petition or proceeding is not dismissed within [**] of filing; (iv) in the event that Schrödinger is unable to pay its debts as they come due in the normal course of business; and (v) in the event
Schrödinger (or any entity or person acting on its behalf initiates any proceeding or otherwise asserts any claim challenging the validity or enforceability of any Patent in any court, administrative agency or other forum, as addressed in
Section 8.e. Termination under (ii) - (v) shall be effective upon date of notice sent pursuant to Section 21. Unless terminated earlier under any provision of this Agreement, the term of the licenses granted hereunder shall extend, on a country-by-country and product-by-product basis, until the later of (i) the expiration of the last to expire of the issued patents
falling within the definition of Patents; (ii) fifteen (15) years after the first bona fide commercial sale of a Licensed Product in the country in question; and (iii) the date of expiration of the copyright in the Licensed Software. 

  
 18 

 c.    Notwithstanding anything in this Agreement to the contrary,
Schrödinger’s obligation to pay Software Product Royalties and Services Agreement Royalties shall terminate 20 years following the Effective Date. 

d.    The following sections of this Agreement shall survive its expiration or earlier termination: Sections 3.a., 3.b., 6
through 8, 10, 12, 16, 18, 19, 20.d., 20.e., 20.f., 20.g., 20.h., 21, 23, 24, 26, 27. and 29; and to the extent that the situation in Section 20.f. applies, then Sections 2, 13, 15.e. (except in the case of termination for
Schrödinger’s material breach), 15.f., and 15.g., but only during the post-termination wind-down period. 

e.    Any termination of this Agreement shall not adversely affect any rights or obligations that may have accrued to
either party prior to the date of termination, including without limitation Schrödinger’s obligation to pay all amounts due and payable under Sections 7, 8 and 15 hereof. 

f.    Upon any termination of this Agreement for any reason other than Schrödinger’s failure to cure a material
breach of this Agreement Schrödinger shall have the right: 
 (1)    For [**] or such longer period
as the parties may reasonably agree, (i) to market, license and sell the Licensed Products, subject to Schrödinger’s continued obligation to pay royalties when due as provided herein; and (ii) to continue the development and
maintenance of the Licensed Products; and 
 (2)    Until the expiration or earlier termination of any
Services Agreement in effect as of the date of termination, to use the Licensed Products to the extent needed for Schrödinger to perform its obligations thereunder. 

g.    Upon any termination of this Agreement for any reason, including for Schrödinger’s failure to cure a
material breach of this Agreement, End Users shall have the right to continue to use the Licensed Products, subject to the terms of their license agreements with Schrödinger, it being understood that Schrödinger would continue to provide
maintenance and support to these End Users during such period. 
 h.    Notwithstanding anything to the contrary in the
Agreement, to the extent the manufacture of a Licensed Product is Covered By an issued patent within the definition of Patents and occurs prior to the expiration of such issued patent, the sale of that Licensed Product after the expiration date of
the issued patent shall still constitute a royalty-bearing sale under Section 7. 
 21.    Notices. Any
notice required or permitted to be given under this Agreement shall be sufficient if in writing and shall be considered given (i) when mailed by certified mail (return receipt requested), postage prepaid, or ( ii ) on the date of actual
delivery by hand or overnight delivery, with receipt acknowledged, 

  
 19 

			
	if to Columbia, to:	  	Executive Director
		  	Science & Technology Ventures
		  	80 Claremont Avenue, #4F
		  	New York, NY 10027-5712
		
	copy to:	  	General Counsel
		  	Columbia University
		  	412 Low Memorial Library
		  	535 West 116th Street, Mail Code 4308
		  	New York, New York 10027
		
	if to Schrödinger, to:	  	Dr. Ramy Farid
		  	President Schrödinger, LLC
		  	120 West 45th street, 29th Floor
		  	New York, NY 10036
		
	copy to:	  	General Counsel
		  	Schrödinger, LLC
		  	120 West 45th Street, 29th Floor
		  	New York, NY 10036

 or to such other address as a party may specify by notice here under. 

22.    Assignment. This Agreement and the licenses granted hereunder shall be assignable by Schrödinger to
(i) an Affiliate of Schrödinger, or (ii) an entity in connection with a reorganization, merger, consolidation, acquisition, or other restructuring involving all or substantially all of the voting securities and/or assets of
Schrödinger. Except as otherwise set forth in the foregoing sentence, this Agreement and the licenses granted hereunder may not be assigned or transferred without the prior written consent of Columbia, which shall not be unreasonably withheld
or delayed beyond [**] after submission to Columbia of a request for such consent, provided that in connection with such a request, the name of the proposed assignee and such additional information relating to the proposed assignee as Columbia may
reasonably request shall also be submitted. 
 23.    Waiver and Election of Remedies. The failure of any party
to insist upon strict adherence to any term of this Agreement on any occasion shall not be considered a waiver or deprive that party thereafter of the right to insist upon strict adherence to that term or any other term of this Agreement. All
waivers must be in writing and signed by an authorized representative of the party against which such waiver is being sought. The pursuit by either party of any remedy to which it is entitled at any time or continuation of the Agreement despite a
breach by the other shall not be deemed an election of remedies or waiver of the right to pursue any other remedies to which it may be entitled. 

24.    Binding on Successors. This Agreement shall be binding upon and inure to the benefit of the parties and
their respective successors and assigns to the extent assignment is permitted under this Agreement. 

  
 20 

 25.    Independent Contractors. It is the express intention of
the parties that the relationship of Columbia and Schrödinger shall be that of independent contractors and shall not be that of agents, partners or joint venturers. Nothing in this Agreement is intended or shall be construed to permit or
authorize either party to incur, or represent that it has the power to incur, any obligation or liability on behalf of the other party. 

26.    Entire Agreement; Amendment. This Agreement, together with the Exhibits, sets forth the entire agreement
between the parties concerning the subject matter hereof and supersedes all previous agreements, written or oral, concerning such subject matter. This Agreement may be amended only by written agreement duly executed by the parties. 

27.    Severability. In the event that any provision of this Agreement is held by a court of competent jurisdiction
to be unenforceable because it is invalid, illegal or unenforceable, that provision shall be deemed severed from the rest of the Agreement, and the remaining provisions shall remain enforceable. The parties shall replace such invalidated or
unenforceable provision with a valid and enforceable provision that will achieve, to the extent possible, the economic, business and other purposes of the replaced provision. 

28.    No Third-Party Beneficiaries. Except as expressly set forth herein, the parties hereto agree that there are
no third-party beneficiaries of any kind to this Agreement. 
 29.    Governing Law. This Agreement shall be
governed by and construed in accordance with the internal substantive laws or the State of New York as applicable to agreements made and wholly performed within the State of New York, and without reference to the conflict or choice of laws
principles of any jurisdiction. Unless otherwise separately agreed upon in writing, the parties agree that any and all claims arising under or related to this Agreement shall be heard and determined only in either the United States District Court
for the Southern District or New York or in the courts of the State of New York located in the City and County of New York, and the parties irrevocably agree to submit themselves to the exclusive and personal jurisdiction of those courts and
irrevocably waive any and all rights any such party may now or hereafter have to object to such jurisdiction or the convenience of the forum. 

30.    Force Majeure. Neither party shall be deemed in default hereunder, nor shall it hold the other party
responsible for, any cessation, interruption or delay in the performance of its obligations hereunder due to earthquake, flood, fire, storm, natural disaster, act of God, war, act of terrorism, armed conflict, labor strike, lockout, or boycott,
provided that the party relying upon this section (i) shall have given the other party written notice thereof promptly and, in any event, within [**] of discovery thereof and (ii) shall take all steps reasonably necessary under the
circumstances to mitigate the effects of the force majeure event upon which such notice is based. 
 31.    Execution
in Counterparts; Facsimile or Electronic Transmission. This Agreement may be executed by facsimile or other electronic transmission, and such electronic transmission shall be valid and binding to the same extent as if it were an original.
Further, this Agreement may be signed in one or more counterparts, all of which when taken together shall constitute the same documents. For all evidentiary purposes, any one complete set of this Agreement shall be considered an original. 

  
 21 

 IN WITNESS WHEREOF, Columbia and Schrödinger have caused this Agreement to be executed
by their duly authorized representatives as of the day and year first written above. 
  

			
	THE TRUSTEES OF COLUMBIA
	UNIVERSITY IN THE CITY OF NEW YORK
		
	By	 	 /s/ Illegible

		 	Executive Director,
		 	Science & Technology Ventures
		
		 	TTS#33921
	
	SCHRÖDINGER, LLC
		
	By	 	 /s/ Ramy Farid

		 	Ramy Farid, Ph.D.
		 	President

  
 22

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