Document:

Portions of this document have been redacted
pursuant to a Request for Confidential Treatment filed with the Securities and Exchange Commission pursuant to Rule 24b-2 under
the Securities Exchange Act of 1934, as amended. Redacted portions are indicated with the notation “*”.

 

1ST AMENDMENT TO CONTRACT RESEARCH
AGREEMENT

 

This Amendment is entered into on March 22, 2013 by and between:

 

Crucell Holland B.V., a Dutch company with offices located
at Archimedesweg 4-6, 2333 CN Leiden, the Netherlands, hereinafter referred to as “Crucell”; and

 

Enumeral Biomedical Corp., a company organized under the
laws of Delaware, U.S.A., with offices located at 1450 Broadway, 24th Floor, New York, NY 10018, U.S.A. (“Enumeral”);

 

(hereinafter individually referred to as “Party” and
collectively as “Parties”)

 

WHEREAS Crucell and Enumeral have signed a Contract Research Agreement,
effective on February 28, 2012 for the performance of * screening services, antibody * services, and discovery of * services (“Agreement”);

 

WHEREAS Parties have agreed to adjust the timelines and amend the
performance conditions for phase 2 of Project 1 under the SOW;

 

NOW THEREFORE THE PARTIES HAVE AGREED AS FOLLOWS:

 

Crucell and Enumeral have agreed to delete on page 10 (of 16) under
the heading “Deliverables” the two bulleted paragraphs that follow this heading and to add, in their place, the following:

 

“Enumeral will conclude the results of the screening
of the first *; following receipt of same; the Full Data Set (as defined below) will be shared with Crucell including * as determined
jointly by both parties and based solely on Enumeral’s microengraving technology; for clarity, the “Full Data Set”
includes all data generated during screening using microengraving, but expressly excludes * except for the * jointly selected for
*. Upon completion of the screening of the first *, defined herein as the *, Enumeral will promptly transfer to Crucell the * resulting
from the screening.

 

Enumeral will conclude the results of the screening of
the second and third *, following receipt of each; the Full Data Set will be shared with Crucell including * as determined jointly
by both parties. Upon completion of the screening of the second and third *, defined herein as the *, Enumeral will promptly transfer
to Crucell the * resulting from the screening of each of the second and third *.”

 

    	 

    	 

    

 

Portions of this document have been redacted
pursuant to a Request for Confidential Treatment filed with the Securities and Exchange Commission pursuant to Rule 24b-2 under
the Securities Exchange Act of 1934, as amended. Redacted portions are indicated with the notation “*”.

 

Crucell and Enumeral have agreed to delete under the Commercial
conditions Project 1 the three paragraphs on page 9 (of 16) beginning “Total amount for the services to be performed...”
and ending with “... (to be supplied by Crucell after execution of this SOW).” and to add in their place the following:

 

“Following conclusion by Enumeral of the screening
of the first *, including the *, and transfer to Crucell the * resulting from such screening, * of the total amount due for Project
1 will become immediately due and payable by Crucell.

 

Crucell expects to provide the second * to Enumeral no
later than August 1st, 2013. Following conclusion by Enumeral of the screening of the second *, including the *, and
transfer to Crucell the * resulting from such screening, * of the total amount due for Project 1 will become immediately due and
payable by Crucell.

 

Crucell expects to provide the third * to Enumeral no
later than Dec 31st, 2013. Following conclusion by Enumeral of the screening of the third *, including the *, and transfer
to Crucell the * resulting from such screening, * of the total amount due for Project 1 will become immediately due and payable
by Crucell.

 

Enumeral will use reasonable efforts to deliver the full
data set and the * within * after delivery of each respective *.”

 

IN WITNESS WHEREOF, Contractor and Crucell have executed
this Amendment in duplicate by their respective, duly authorized, representatives as of the date hereinafter written:

 

	Crucell Holland B.V.	Enumeral Biomedical Corp.
	 	 
	By: /s/ Ken Tignol	By: /s/ Arthur H. Tinkelenberg
	Name: Ken Tignol	Name:  Arthur H. Tinkelenberg
	Title:  CFO	Title:  President and CEO
	Date:  March 25, 2013	Date:  March 25, 2013Portions of this document have been redacted
pursuant to a Request for Confidential Treatment filed with the Securities and Exchange Commission pursuant to Rule 24b-2 under
the Securities Exchange Act of 1934, as amended. Redacted portions are indicated with the notation “*”.

 

MASTER SERVICE PROVIDER AGREEMENT

 

THIS AGREEMENT (the
“Agreement”) is made as of the 14th day of March, 2012 (“Effective Date”), by and between
Anthrogenesis Corporation, a New Jersey Corporation, doing business as Celgene Cellular Therapeutics (a wholly owned subsidiary
of Celgene Corporation) having its principal place of business at 33 Technology Drive, 2nd Floor, Warren, NJ 07059 (together
with its affiliates hereinafter collectively referred to as “CCT”) and Enumeral Biomedical Corporation, having
a place of business at 1450 Broadway, 24th Floor, New York, NY 10018 (hereinafter called “Service Provider”).

 

In consideration of the
mutual promises contained herein, the parties hereby mutually agree as follows:

 

1.    Appointment

 

Service Provider will
perform the services (the “Services”) described in the attached Exhibit(s), made fully a part hereof, according to
the timeframes and schedules listed in said Exhibit(s). In the event that the parties hereto shall reach agreement with respect
to the provision of additional services hereunder, such services shall be set forth in writing and attached hereto as additional
Exhibit(s), which Exhibit(s) shall be made fully a part hereof, and such services shall be deemed to be Services hereunder. No
such additional services shall be approved without first being reduced to a writing, which is executed by the parties hereto. To
the extent that terms contained in Exhibit(s) conflict with this Agreement, the terms and conditions of this Agreement will control.
Service Provider shall advise CCT of the names and provide CCT with the resume(s) of personnel prior to assigning them to perform
the Services if requested by CCT. CCT reserves the right, at its sole discretion, to reject any personnel.

 

2.    Compensation

 

In consideration for Service
Provider’s satisfactory performance of the Services, CCT shall pay Service Provider a fee in the amount and on the terms
specified in Exhibit(s) attached hereto. Invoices must reference the appropriate purchase order number and sent to the attention
of Accounts Payable, Celgene Cellular Therapeutics, 7 Powder Horn Drive, Warren, NJ 07059.

 

CCT shall pay the amount
of each invoice received from Service Provider within forty-five (45) days of receipt by CCT unless CCT has notified Service Provider
within such forty-five (45) day period that it disputes any particular invoiced item(s), which dispute the parties shall attempt
in good faith to resolve. Because of the difficulty in substantiating the validity of claims for payment increases with time, CCT
reserves the right to decline to pay on invoices more than ninety (90) days after an expense has been incurred. In no event will
CCT pay on invoices submitted more than one hundred eighty (180) days after an expense has been incurred.

 

3.    Confidentiality

 

“Confidential Information”
shall, for the purpose of this Agreement, mean all information in any form, tangible or intangible, which may be disclosed, or
has been disclosed by CCT to Service Provider in writing, orally or by observation which is nonpublic, proprietary, a trade secret,
or confidential in nature and all of the information obtained from CCT or generated by Service Provider during the course of its
work for CCT. Service Provider agrees to hold in trust and confidence all Confidential Information. Service Provider further agrees
that it shall not disclose all or any part of such Confidential Information to any third party or make any use thereof (except
to perform the Services pursuant to the provisions of this Agreement), or publish or present any work which in whole or in part
uses or includes Confidential Information, without the prior written consent of CCT. Service Provider agrees to restrict access
to all Confidential Information to only such limited group of its authorized employees, who require such information in connection
with the performance of Services under this Agreement. Such authorized employees shall be under confidentiality obligations at
least as restrictive as set out in this Agreement. It is understood, however, that this restriction shall not apply to information
which Service Provider can demonstrate by its competent written records predating disclosure under this Agreement (i) was known
to it prior to the relationship between CCT and Service Provider, (ii) was lawfully revealed to Service Provider by a third party
which has the legal right to disclose such information, or (iii) is or becomes part of the public domain through no fault of Service
Provider. Service Provider shall return to CCT or destroy all Confidential Information in tangible form (including all copies,
extras or derivatives thereof in any medium) within thirty (30) days after the termination or expiration of this Agreement, or
upon request from CCT, whichever comes first, except that Service Provider may keep one (1) archival copy of such information in
its legal files solely for the purpose of monitoring compliance under this Agreement.

 

    	1

    	 

    

 

4.    Intellectual Property

 

4.1   
Work for Hire

 

The parties expressly agree
that all work performed under this Agreement is a work made for hire as defined under 17 USC Section 101. All communications, materials,
concepts and plans developed by Service Provider which are or have been made, conceived or written by Service Provider or its employees
and which are based upon Services performed by Service Provider for CCT shall belong exclusively to CCT, including, without limitation,
all rights to obtain copyrights therein. In cases where an original work or a copy of an original work cannot be assigned to and
owned by CCT, CCT shall be notified by Service Provider, and Service Provider shall obtain rights of use in CCT’s favor,
as CCT may require. All communications, materials and artwork provided by CCT shall also remain the property of CCT, including,
without limitation, any copyrights or other intellectual property rights therein.

 

4.2    Assignment of Intellectual Property

 

Service Provider hereby
assigns to CCT all intellectual property, including, but not limited to, all patents, patent applications, copyrights, discoveries
and inventions, whether patentable or not, conceived or reduced to practice by Service Provider or its employees, agents or consultants,
alone or jointly with others, during the term of this Agreement, which intellectual property either (i) based upon any information
received from CCT or (ii) directly arising from the Services provided by Service Provider to CCT hereunder (“Intellectual
Property”). Service Provider agrees to disclose promptly and fully all Intellectual Property and to assist, and cause its
employees, agents and consultants to assist, CCT in every reasonable way, at CCT’s expense, to protect the rights of CCT
or any affiliate in the Intellectual Property, including, without limitation, to obtain patents and copyrights thereon in any and
all countries.

 

4.3    Background Technology

 

Notwithstanding the foregoing,
nothing in this Agreement expressly or otherwise provides for a license to Celgene of Service Provider’s pre-existing technology,
or any inventions, discoveries or improvements to Service Provider’s pre-existing technology which in no way incorporates,
references or utilizes any Celgene Confidential Information (together, “Improvements”), whether patentable or not.
For clarity, Improvements will be owned solely by Service Provider including, but not limited to, use of Service Provider’s
technology to measure from patient-derived materials, the single cell secretion of certain proteins with potential utility in determining
the presence or absence of disease processes.

 

5.    Term and Termination

 

This Agreement shall be
effective as of the Effective Date and shall remain in full effect for three (3) years from the Effective Date, unless terminated
in accordance with the terms below and may be renewed by mutual consent of Service Provider and CCT for such additional period
as the parties may agree upon; provided, however, if an Exhibit for Services is executed by the parties prior to the expiration
or termination of this Agreement and the Services under the Exhibit have not been completed prior to the expiration or termination
of the Agreement, then the term of this Agreement shall be automatically extended to expire on the earlier of (a) the completion
of the Services under the Exhibit, or (b) the termination by the parties of such Exhibit in accordance with Section 5(a) or 5(b)
below:

 

    	2

    	 

    

 

		a.	CCT may:

 

(i) terminate
this Agreement or any Exhibit, at any time upon thirty (30) days written notice to Service Provider;

 

(ii) terminate
this Agreement immediately, in the event of the filing of a petition in voluntary bankruptcy or an assignment for the benefit of
creditors by Service Provider, or upon other action taken or suffered, voluntarily or involuntarily, under any federal or state
law for the benefit of debtors by Service Provider, except for the filing of a petition in involuntary bankruptcy against Service
Provider which is dismissed within thirty (30) days thereafter;

 

(iii) give notice
of the immediate termination of this Agreement in the event Service Provider shall materially default in the performance of any
duty or obligation imposed upon it by this Agreement and such default shall continue for a period of thirty (30) days after written
notice thereof has been given to Service Provider by CCT.

 

		b.	Service Provider may:

 

(i) terminate
this Agreement in the event CCT shall materially default in the performance of any duty or obligation imposed upon it by this Agreement
and such default shall continue for a period of thirty (30) days after written notice thereof has been given to CCT by Service
Provider.

 

Termination or expiration of the term hereof
shall not relieve Service Provider of the obligations imposed upon Service Provider, as set forth in paragraph 16.5. In the event
of termination by CCT for any reason other than Service Provider’s breach of the terms of this Agreement, Service Provider
shall be reimbursed for costs incurred directly in the performance of the Services prior to the date of the notice of termination,
and for all reasonable non-cancelable commitments incurred directly in the performance of the Services and outstanding as of that
date, provided that Service Provider uses its best efforts to mitigate same.

 

6.    Independent Contractor

 

The relationship of Service
Provider to CCT is that of an independent contractor and nothing herein shall be construed as creating any other such relationship.
Service Provider may adopt such arrangements as it may desire with regard to the details of the Services performed hereunder, the
hours during which the Services are to be provided, and the place or places where the Services are to be furnished, provided that
such details, hours and places shall be consistent with the proper accomplishment of the Services, and provided further that the
Services shall be performed in a manner calculated to attain the most satisfactory results for CCT. CCT and Service Provider acknowledge
and agree that the personnel employed by Service Provider in performing the Services shall remain at all times employees of Service
Provider, and Service Provider shall remain solely liable for all aspects of the employment of such persons including, recruitment,
termination, training, promotion, compensation, benefits, F.I.C.A., payroll taxes and all other deductions or payments to be made
by employers for or on behalf of employees. Service Provider shall not be, and shall not represent itself, or any of its employees,
officers, directors, representatives, agents or contractors to anyone as an employee of CCT, or as being entitled to any employment
rights or benefits from CCT.

 

    	3

    	 

    

 

7.    Compliance

 

In the event Service Provider
is to perform any of the Services on CCT’s premises, Service Provider agrees that it shall comply with the applicable safety
rules and regulations of the particular location where the Services are to be performed, and CCT agrees that said safety rules
and regulations shall be made available to Service Provider before the commencement of performance of any such Service.

 

In the event Service Provider
receives notice of an adverse event in error from a third party, Service Provider will inform Celgene’s Drug Safety Group
within twenty-four (24) hours of receiving the notice, via Global Drug Safety Department, 86 Morris Avenue, Summit, NJ 07901, phone:
800-640-7854; fax 908-673-9115/9154. The Service Provider shall collect from the reporter and provide to Celgene the following
minimum information: name, credentials, address, telephone and fax number of the reporter of the adverse event.

 

8.    Audit

 

8.1    During the term of
this Agreement and for two (2) years after its expiration or termination, CCT shall have the right to audit and inspect all documentation
related to the Services, including any financial records of Service Provider associated with this Agreement or any Exhibit under
this Agreement. Service Provider will make available all such documentation upon request for inspection, copying, review and audit
at reasonable times by representatives of CCT or any regulatory agencies. Such records may include, without limitation, invoice
records, invoices from third parties, contracts with third parties and payments relating to this Agreement. To the extent such
records are not separable from other customer records, Service Provider will give reasonable access to the records to an independent
auditor selected by CCT, who will audit the records and may disclose the results of the audit only to the extent it relates to
this Agreement. In no event shall other customer information be disclosed to CCT.

 

8.2    CCT will have the right,
but not the obligation, to independently visit Service Provider or any sites where the Services are performed to review performance
of Services herein. In the event CCT intends to undertake such visits, CCT will provide reasonable notification to Services Provider,
and Service Provider will provide assistance and cooperation.

 

8.3    Service Provider agrees
to take reasonable steps that are requested by CCT as a result of an audit to cure deficiencies in all documentation related to
the Services. Service Provider will retain copies of all documentation related to the Services, in conformance with applicable
national and local regulations and as specified by CCT. Service Provider agrees to advise CCT of any regulatory inspection and
to provide CCT with a copy of any inspection report. Any response to a regulatory agency will be subject to approval by CCT prior
to issuance. Such approval will not be unreasonable withheld.

 

9.    Indemnification

 

9.1 Indemnification by
Service Provider

 

Service Provider shall
indemnify, defend and hold harmless CCT and its officers, directors, employees and agents from and against all claims, causes of
action, suits, damages and costs arising out of, resulting from, or otherwise in respect of, the negligent acts, or willful misconduct
of Service Provider or its officers, directors, employees or agents pertaining to the activities to be carried out pursuant to
Service Provider’s obligations under this Agreement; provided, however, that Service Provider shall not hold CCT harmless
from claims to the extent arising out of the negligence or willful misconduct of CCT or its officers, directors, employees or agents.

 

9.2 Indemnification by
CCT

 

CCT shall indemnify, defend
and hold harmless Service Provider and its officers, directors, employees and agents from and against all claims, causes of action,
suits, damages and costs arising out of, resulting from, the negligent acts or willful misconduct of CCT or its officers, directors,
employees or agents pertaining to the activities to be carried out pursuant to this Agreement; provided, however, that CCT shall
not hold Service Provider harmless from claims to the extent arising out of the negligence or willful misconduct of Service Provider
or its officers, directors, employees or agents.

 

    	4

    	 

    

 

10.    Equal Opportunity

 

Service Provider acknowledges
that it understands that CCT is an Equal Opportunity Employer and Service Provider warrants that Service Provider complies with
the Fair Labor Standard Act of 1938, as amended. Service Provider agrees that, if this Agreement is construed to be a subcontract
within the meaning of the Rules and Regulations approved by the United States Secretary of Labor pursuant to Executive Order 11246,
as amended, the Vietnam Era Veterans Readjustment Act of 1974, as amended, or the Rehabilitation Act of 1973, as amended, or of
the regulations issued pursuant to Executive Order 11625, the provisions of those regulations as well as the Equal Opportunity
and Nondiscrimination provision of Section 202 of Executive Order 11246 shall be incorporated herein by reference and shall be
binding upon Service Provider as part of this Agreement.

 

11.    Insurance

 

Commencing with the performance
of Services hereunder, Service Provider shall during the term of Service Provider’s obligations under Section 9 hereof, maintain
insurance of the type and minimum coverage indicated below. The term of coverage shall be evidenced by certificates of insurance
to be furnished at CCT’s request.

 

	Type	 	Minimum Limits
	Worker’s Compensation	 	Statutory
	Employer’s Liability	 	$100,000
	General Liability	 	
        $1,000,000

        (Combined single limit)

	Automobile – any auto	 	
        $1,000,000

        (Combined single limit)

 

12.    Service Provider’s Warranties; Conflicts
of Interest

 

12.1 No Conflict of Interest
or FDA Debarment

 

Service Provider represents
and warrants that: (i) it has no obligations to any third party which (a) will in any way limit or restrict its ability to perform
Services for CCT hereunder or (b) conflict with the rights granted to CCT hereunder, (ii) it shall not disclose to CCT, nor make
any use of in the performance of Services hereunder any trade secrets or confidential or proprietary information of any third party
without the consent of such third party, and (iii) it has not been debarred or suspended by the FDA from providing services to
a company that has a pending or approved drug product application.

 

12.2 Requirement to Advise
of Future Conflicts

 

Service Provider further
warrants and affirms that it shall advise CCT of any relationship described in Section 12.1(i) that might arise during the term
of this Agreement. In such event, CCT shall have the option to immediately terminate this Agreement without further liability to
Service Provider other than the obligations to pay for Services actually rendered as of the date of termination.

 

12.3 Professional Standards

 

Service Provider warrants
that (i) it possesses the necessary expertise to perform the Services hereunder consistent with the highest professional standards
of the industry, and (ii) the Services will be performed in a professional and workmanlike manner consistent with the highest professional
standards of the industry. Service Provider shall re-perform any Services not in compliance with this warranty brought to its attention
within a reasonable time after those Services are performed.

 

    	5

    	 

    

 

13.    Tax Reporting and Payment

 

Any tax or other governmental
charges that apply to this Agreement or to the compensation payable to Service Provider hereunder are conclusively presumed to
be included in such compensation and accordingly, any such tax or governmental charge shall not be added to any invoice submitted
by Service Provider. CCT is not responsible for payment of any employment, self-employment, or withholding taxes imposed as a result
of the performance of Services under this Agreement, whether by Service Provider, its employees, agents, consultants or sub-contractors.
Service Provider shall maintain records of the employee benefits provided to any employee of Service Provider performing Services
hereunder on a substantially full-time basis for a period of one (1) year or longer and such other information needed by CCT to
demonstrate compliance with the requirements of Internal Revenue Code Section 414(n) and related sub-sections, as amended from
time-to-time, pertaining to “leased employees”. For this purpose “on a substantially full-time basis” shall
mean fifteen hundred (1,500) hours in a twelve (12) month period or such amount specified by US tax regulation or notice in effect
during the term of this Agreement. Service Provider shall maintain such records for at least six (6) years and furnish such data
to CCT at its request.

 

14.    Notice

 

Any notice or other communication
required or permitted under this Agreement shall be in writing and shall be made by overnight courier or certified mail, return
receipt requested, and will be deemed given as of the date it is received by the receiving party. Notice shall be given to the
parties at the address listed below:

 

If to Service Provider:

 

Enumeral Biomedical Corporation

1450 Broadway, 24th
Floor

New York, NY 10018

Attention: Arthur Tinkelenberg

 

If to CCT:

 

Celgene Cellular Therapeutics

33 Technology Drive, 2nd
Floor

Warren, NJ 07059

Attention: *

 

With a copy to:

 

Vice President, Legal and
Chief Counsel

Celgene Corporation

86 Morris Avenue

Summit, NJ 07901

Fax: (908) 673-2771

 

15.    Miscellaneous Provisions

 

15.1    Assignability

 

No assignment by Service
Provider of this Agreement or any of its rights, duties or obligations hereunder, shall be effective without CCT’s prior
written consent, and any attempted assignment in violation of this paragraph 16.1 shall be void.

 

15.2    Relief

 

In the event of the actual
or threatened breach by Service Provider of any of the terms of paragraphs 3 or 4 hereof, CCT shall have the right to specific
performance and injunctive relief. The rights granted by this paragraph are in addition to all other remedies and rights available
at law or in equity.

 

15.3    Complete Agreement

 

This Agreement, together
with any Exhibit(s) attached hereto, constitutes the entire agreement between the parties hereto with respect to the subject matter
hereof, and there are no other agreements or understandings, written or oral, between the parties relating to the subject matter
of this Agreement.

 

15.4    Amendments

 

This Agreement may not
be altered, changed or amended except by a writing signed by each of the parties hereto.

 

15.5    Survival

 

The provisions of paragraphs
3, 4, 8, 9, 10, 11, 12, 13, 15.9 and 15.10 of this Agreement shall survive the expiration and/or termination of this Agreement.

 

15.6    Severability

 

In the event that any provision
of this Agreement is held illegal or invalid for any reason, such provision shall not affect the remaining parts of this Agreement,
but this Agreement shall be construed and enforced as if that legal and invalid provision had never been inserted herein.

 

    	6

    	 

    

 

15.7    Captions and Headings

 

The captions and headings
in this Agreement are for convenience and reference only, and they shall in no way be held to explain, modify, or construe the
meaning of the terms of this Agreement.

 

15.8    Counterpart Originals

 

This Agreement may be executed
in multiple counterparts, each of which, when executed shall be deemed to be an original and all of which together shall constitute
one and the same document.

 

15.9    Governing Law; Jurisdiction

 

This Agreement shall be
governed by, and construed in accordance with, the laws of the State of New Jersey without giving effect to the choice of law principles
thereof. The parties hereby consent to the jurisdiction of the state and federal courts sitting in the State of New Jersey, and
any Courts of Appeal therefrom, in connection with any dispute arising in connection with this Agreement or the provision by Service
Provider of Services hereunder.

 

15.10   Use of Name.

 

Both parties agree that
it will not use the name, logos, marks or trade names of the other party (or its affiliates), including, without limitation, in
any press release or public announcement, or in the promotion of any product or service without the prior written consent of such
party’s Investor Relations department. The obligations in this section shall survive expiration or termination of the Agreement.

 

THIS AGREEMENT WILL NOT BE CONSIDERED ACCEPTED,
APPROVED, OR OTHERWISE EFFECTIVE UNTIL THE SIGNATURE OF EACH PARTY IS AFFIXED IN THE SPACE PROVIDED BELOW. PLEASE BE ADVISED THAT
A FULLY EXECUTED AGREEMENT MUST BE RETURNED TO AND RECEIVED BY CCT WITHIN 60 DAYS OF THE GENERATION OF THE CONTRACT. IF NOT RECEIVED
WITHIN THAT PERIOD, CCT RESERVES THE RIGHT TO RE-EVALUATE THE TERMS AND CONDITIONS OF THE AGREEMENT, INCLUDING HOLDING THE AGREEMENT
NULL AND VOID.

 

IN WITNESS WHEREOF,
the parties hereto have caused their duly authorized representatives to sign this Agreement upon the date first set forth above.

 

	ENUMERAL BIOMEDICAL CORPORATION	 	CELGENE CELLULAR THERAPEUTICS
	 	 	 
	By: /s/ Arthur Tinkelenberg	 	By: /s/ George Matcham (Signature)
	 	 	 
	Name: Arthur Tinkelenberg, PhD	 	Name: George Matcham (Print)
	 	 	 
	Title: Chief Executive Officer	 	Title: COO & SVP
	 	 	 
	Date: March 14th 2012	 	Date: 3-27-12
	 	 	 
	 	 	Approved for Legal Content: 3/22/2012

 

    	7

    	 

    

 

WORK ORDER Nr. 1

 

Work Order for assay assessment for *

 

Celgene Corporation and Service Provider have entered into a Master
Service Provider Agreement dated March 14, 2012 (the “Agreement”) which provides that a Work Order be entered into
to set out with specificity the details of a particular study and Services. The terms contained herein are pursuant to and governed
by such Agreement.

 

This Work Order is effective as of October 29th, 2012,
and shall terminate as of December 31st, 2013, and is by and between Celgene Cellular Therapeutics (a whole owned subsidiary
of Celgene Corporation) with its address located at 33 Technology Drive, 2nd Floor, Warren, NJ 07059 (hereinafter “CCT”)
and Enumeral Biomedical Corporation, with its address located at 1450 Broadway, 24th Floor, New York, NY 10018 (hereinafter
“Service Provider”).

 

		I.	Description of Services:

 

This Work Order has been generated based on
the assumptions listed below:

·    Deliverable
1 – An assay using Service Provider’s technology will be designed that will encompass *. Deliverable 1 will be considered
completed upon CCT’s review and approval from data of applying the assay to *.

·    Deliverable
2 – After feedback from CCT, the assay will be optimized in order to be applied to *. Deliverable 2 will be considered completed
upon CCT’s review and approval of the data from applying the newly-optimized assay to *.

·    Deliverable
3 – Data comprising * and * from * and acceptable controls will be delivered to CCT. Deliverable 3 will be considered completed
upon delivery and approval of data from CCT.

 

		II.	Key Personnel

 

Derek Brand has been identified as Key Personnel,
according to the terms of the Agreement.

 

		III.	Payment Schedule

 

Service Provider will invoice Celgene for all
services completed for the budget category for which a trigger has been achieved:

 

	Milestone	 	Payment Amount
	Initiation of project	 	*
	Review and Approval of data from Deliverable No. 1	 	*
	Review and Approval of data from Deliverable No. 2	 	*
	Completion of project (Deliverable 3)	 	*
	Total	 	*

 

·    *,
and affiliated reagents totaling an estimated *.

 

    	Page 1 of 2

    	 

    

 

Professional Costs:

 

Total professional costs for the services shall
not exceed * and will be paid according to the following schedule, unless otherwise agreed. A final reconciliation of budget line
items and services completed will be performed prior to submitting the final invoice. Such reconciliation will be evidenced in
a Change Order, if required and reflected in the final invoice.

 

Pass-Through Costs

 

Total pass-through costs for the services shall
not exceed * unless otherwise agreed to by both parties and shall be invoiced and reimbursed on a monthly basis.

 

Invoices must reference the purchase order
(PO) number and are to be sent to the attention of:

 

Celgene Corporation

Attn: Accounts Payable

P.O. Box 1007

Summit, NJ 07902-1007

Referencing: *

 

Celgene shall pay the amount of each invoice
received from Service Provider within forty-five (45) days of receipt by Celgene, unless Celgene has notified Service Provider
within such forty-five (45) day period that it disputes any particular invoiced item(s), which dispute the parties shall attempt
in good faith to resolve.

 

Because of the difficulty in substantiating
the validity of claims for payment increases with time, Celgene reserves the right to decline to pay for expenses that are invoiced
more than ninety (90) days after an expense has been incurred. In no event will Celgene pay on invoices submitted more than one
hundred eighty (180) days after an expense has been incurred.

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK – SIGNATURE PAGE
FOLLOWS]

 

IN WITNESS WHEREOF, the parties have executed this Work Order the
day and year set forth above.

 

	Enumeral Biomedical Corporation	 	Celgene Corporation
	 	 	 
	By: /s/ Arthur H. Tinkelenberg	 	By: Please see attached
	 	 	 
	Title:  Arthur H. Tinkelenberg, President & CEO	 	Title: ________________________________
	 	 	 
	Date:  10/19/2012	 	Date: ________________________________

 

    	Page 2 of 2

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