Document:

EX-4.1

 Exhibit 4.1 

THIRD AMENDED AND RESTATED STOCKHOLDERS AGREEMENT 

THIS THIRD AMENDED AND RESTATED STOCKHOLDERS AGREEMENT (this “Agreement”), is made as of December 18, 2017, by and among
Centrexion Therapeutics Corporation, a Delaware corporation (the “Company”), the Key Holders (as defined below), each Holder (as defined below) listed on Schedule I hereto (each Key Holder and Holder, a
“Stockholder” and collectively, the “Stockholders”) and each stockholder of the Company that becomes a party to this Agreement in accordance with Section 6.9 hereof (each, an
“Additional Stockholder”). Capitalized terms used in this Agreement but not otherwise defined have the meanings set forth in Sections 1.1 and 1.2. 

RECITALS 

WHEREAS, certain Stockholders (the “Existing Stockholders”) possess certain rights pursuant to that certain Second
Amended and Restated Stockholders Agreement, dated as of December 30, 2016 (the “Prior Agreement”); and 

WHEREAS, certain Stockholders are parties to that certain Series D Preferred Stock Purchase Agreement, dated as of the date hereof,
entered into in connection with a private placement of the Series D Convertible Preferred Stock of the Company (the “Purchase Agreement”), under which certain of the Company’s and such Stockholders’ obligations are
conditioned upon the execution and delivery of this Agreement; and 
 WHEREAS, pursuant to Section 6.6 of
the Prior Agreement, any terms thereof may be amended with the written consent of (a) the Holders (as defined in the Prior Agreement) of a majority of the Voting Securities (as defined in the Prior Agreement) then outstanding, (b) the
Holders (as defined in the Prior Agreement) of a majority of the Common Stock, (c) the Holders (as defined in the Prior Agreement) of a majority of the Series A Convertible Preferred Stock (collectively, the Requisite
Stockholders”), and the Company; and 
 WHEREAS, the Company and the Requisite Stockholders desire to amend and restate the
Prior Agreement as set forth herein; and 
 WHEREAS, the Stockholders and the Company hereby agree that this Agreement shall govern
the rights and obligations of the Stockholders and the Company and certain other matters as set forth in this Agreement, subject to the approval of the Requisite Stockholders. 

NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Requisite
Stockholders hereby agree that the Prior Agreement is hereby amended and restated in its entirety to read as follows, and the parties hereto agree as follows: 

1. Definitions. 
 1.1
Definitions. For purposes of this Agreement: 
 “Affiliate” means, with respect to any specified Person, any
other Person who, directly or indirectly, controls, is controlled by, or is under common control with such Person, including without limitation any general partner, managing member, officer or director of such Person or any venture capital fund or
other pooled investment fund now or hereafter existing that is controlled by one or more general partners or managing members of, or shares the same management company with, such Person. For purposes of this definition, the term
“control” (including the terms controlling, controlled by and under common control with) means the possession, direct or indirect, of the power to direct or cause the direction of the management and policies of a person, whether
through the ownership of voting securities or instruments, by contract, or otherwise. 

 “Board” means the board of directors of the Company. 

“Business Day” means any day other than a Saturday, Sunday or other day on which commercial banks in the City of New York are
authorized or required to close. 
 “Certificate of Incorporation” means the Company’s Amended and Restated
Certificate of Incorporation, as may be amended and/or restated from time to time. 
 “Common Stock” means shares of the
Company’s common stock, par value $0.001 per share. 
 “Competitor” means a Person engaged, directly or indirectly
(including through any partnership, limited liability company, corporation, joint venture or similar arrangement (whether now existing or formed hereafter)), in the business of the Company or contemplated to be entered into by the Company, but shall
not include any financial investment firm or collective investment vehicle that, together with its Affiliates, holds less than five percent (5%) of the outstanding equity of any Competitor and does not, nor do any of its Affiliates, have a right,
directly or indirectly, to designate any members of the board of directors of any Competitor. 
 “Damages” means any loss,
damage, claim or liability (joint or several) to which a party hereto may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such loss, damage, claim or liability (or any action in respect thereof)
arises out of or is based upon: (a) any untrue statement or alleged untrue statement of a material fact contained in any registration statement of the Company, including any preliminary prospectus or final prospectus contained therein or any
amendments or supplements thereto; (b) an omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading; or (c) any violation or alleged violation by
the indemnifying party (or any of its agents or Affiliates) of the Securities Act, the Exchange Act, any state securities law, or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 “Excluded Registration” means (a) a registration (including a registration on Form
S-8) relating to the sale of securities or instruments to employees of the Company or a subsidiary pursuant to a stock option, stock purchase or similar plan; (b) a registration relating to an SEC Rule
145 transaction; (c) a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities or (d) a registration
in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered. 

  
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 “FINRA” means Financial Industry Regulatory Authority, Inc. 

“Form S-1” means such form under the Securities Act as in effect on the date hereof
or any successor registration form under the Securities Act subsequently adopted by the SEC. 
 “Form
S-3” means such form under the Securities Act as in effect on the date hereof or any registration form under the Securities Act subsequently adopted by the SEC that permits incorporation of
substantial information by reference to other documents filed by the Company with the SEC. 
 “GAAP” means generally
accepted accounting principles in the United States. 
 “Holder” means any holder of Registrable Securities who is a party
to this Agreement. 
 “Immediate Family Member” means a child, stepchild, grandchild, parent, stepparent, grandparent,
spouse, life partners or others covered under the applicable domestic relations statute, sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law or sister-in-law, including, adoptive relationships, of a natural person
referred to herein. 
 “Initiating Holders” means, collectively, Holders who properly initiate a registration request under
this Agreement. 
 “IPO” means the Company’s first underwritten public offering of the Common Stock pursuant to a
registration statement under the Securities Act. 
 “Key Holders” means (a) Sol J. Barer so long as he is the Holder
of a majority of the Voting Securities held by him as of November 20, 2013, and after a Transfer of a majority of such Voting Securities, the transferee of a majority of such Voting Securities, (b) Isaac Blech so long as he is the Holder
of a majority of the Voting Securities held by him as of November 20, 2013, and after a Transfer of a majority of such Voting Securities, the transferee of a majority of such Voting Securities and (c) Jeffrey B. Kindler so long as he is
the Holder of a majority of the Voting Securities held by him as of November 20, 2013, and after a Transfer of a majority of such Voting Securities, the transferee of a majority of such Voting Securities. 

“NYSE” means the New York Stock Exchange. 

“Person” means any individual, corporation, partnership, trust, limited liability company, association or other entity. 

“Preferred Stock” means, collectively, the Series A Convertible Preferred Stock, Series B Convertible Preferred Stock, Series
C Convertible Preferred Stock and Series D Convertible Preferred Stock. 

  
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 “Proposed Key Holder Transfer” means any assignment, sale, offer to sell,
pledge, mortgage, hypothecation, encumbrance, disposition of or any other like transfer or encumbering of any Transfer Stock (or any interest therein) proposed by any of the Key Holders. 

“Proposed Transfer Notice” means written notice from a Key Holder setting forth the terms and conditions of a Proposed Key
Holder Transfer. 
 “Proposed Transferee” means any person to whom a Key Holder proposes to make a Proposed Key Holder
Transfer. 
 “Pro Rata Portion” means, with respect to the number of shares of Common Stock to be sold by each
participating Stockholder pursuant to Section 5.2, the number of shares of Common Stock equal to the product of (x) the total number of shares of Common Stock the Proposed Transferee proposes to purchase and (y) a
fraction (A) the numerator of which is equal to the number of shares of Common Stock then held by such Stockholder and (B) the denominator of which is equal to the number of shares then held by all of the participating Stockholders
(including, for the avoidance of doubt, the Selling Stockholder). 
 “Registrable Securities” means (a) the Common
Stock held by the Stockholders on the date hereof or acquired after the date hereof and prior to the IPO, (b) the Common Stock issuable or issued upon conversion of the Preferred Stock (the “Conversion Common Stock”); (c) the
Common Stock issuable or issued upon exercise of the Warrants; (d) any Common Stock issued prior to the IPO upon the exercise of a Company stock option and (e) any Common Stock issued as (or issuable upon the conversion or exercise of any
warrant, right, or other security or instrument that is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, Conversion Common Stock; excluding in all cases other than with respect to
Section 4, however, any Registrable Securities sold by a Person in a transaction in which the applicable rights under this Agreement are not assigned pursuant to Section 6.1, and excluding for
purposes of Section 2 any shares for which registration rights have terminated pursuant to Section 2.12. 

“Registrable Securities then outstanding” means the number of shares determined by adding the number of shares of outstanding
Common Stock and the number of shares of Common Stock issuable (directly or indirectly) pursuant to then exercisable and/or convertible securities or instruments that are Registrable Securities. 

“Sale of the Company” shall mean (a) a transaction that qualifies as a Deemed Liquidation Event (as defined in the
Certificate of Incorporation) or (b) a transaction or series of related transactions in which a Person, or a group of related Persons, acquires from stockholders of the Company shares representing more than fifty percent (50%) of the
outstanding voting power of the Company (a “Stock Sale”). 
 “Sale Notice” means a written notice
delivered by the Selling Stockholder to the Company as required by Section 5.2, including the detail set forth in Section 5.2. 

“SEC” means the Securities and Exchange Commission. 

  
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 “SEC Rule 144” means Rule 144 promulgated by the SEC under the Securities
Act. 
 “SEC Rule 145” means Rule 145 promulgated by the SEC under the Securities Act. 

“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 

“Selling Expenses” means all underwriting discounts, selling commissions and stock transfer taxes applicable to the sale of
Registrable Securities, and fees and disbursements of counsel for any Holder, except for the fees and disbursements of the Selling Stockholder Counsel borne and paid by the Company as provided in Section 2.6. 

“Selling Stockholder” means a Holder who, together with its Affiliates, holds no less than 50% of the outstanding Common
Stock of the Company, on an as-converted basis. 
 “Series A Convertible Preferred
Stock” means shares of the Company’s Series A Convertible Preferred Stock, par value $0.001 per share. 
 “Series B
Convertible Preferred Stock” means shares of the Company’s Series B Convertible Preferred Stock, par value $0.001 per share. 

“Series C Convertible Preferred Stock” means shares of the Company’s Series C Convertible Preferred Stock, par value
$0.001 per share. 
 “Series D Convertible Preferred Stock” means shares of the Company’s Series D Convertible
Preferred Stock, par value $0.001 per share. 
 “Tag-along Notice” means the notice
delivered by each Tag-along Stockholder to the Selling Stockholder pursuant to Section 5.2. 

“Tag-along Period” means the period between receipt of a Sale Notice and five
Business Days thereafter, during which time a Tag-along Stockholder may deliver a Tag-along Notice. 

“Tag-along Sale” means a sale of Common Stock by a Selling Stockholder, in which
Stockholders are entitled to participate pursuant to Section 5.2. 

“Tag-along Stockholder” means a Stockholder electing to participate in a Tag-along Sale pursuant to Section 5.2. 
 “Transfer” means to,
directly or indirectly, sell, transfer, assign, pledge, encumber, hypothecate or similarly dispose of, either voluntarily or involuntarily, by operation of law or otherwise, or to enter into any contract, option or other arrangement or understanding
with respect to the sale, transfer, assignment, pledge, encumbrance, hypothecation or similar disposition of, any shares Voting Securities owned by a Person or any interest (including a beneficial interest) in any Voting Securities owned by a
Person. “Transfer”, when used as a noun, shall have a correlative meaning. 

  
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 “Voting Securities” means the Common Stock, the Preferred Stock and any
other securities or instruments of the Company that have a right to vote in respect of any matters related to the Company, in each case, currently owned or hereafter acquired by a Stockholder, and any securities or instruments issued in respect of
any of the foregoing, or in substitution therefor, in connection with any stock split, dividend or combination, or any reclassification, recapitalization, merger, consolidation, exchange or similar reorganization. 

“Warrants” means (i) those certain Warrants to purchase Series C Convertible Preferred Stock issued pursuant to the
terms of that certain Note and Warrant Purchase Agreement, dated as of March 1, 2016, April 8, 2016, April 29, 2016 and June 14, 2016 and (ii) those certain Warrants to purchase Series D Convertible Preferred Stock issued
pursuant to the terms of that certain Note and Warrant Purchase Agreement, dated as of October 10, 2017. 
 1.2
Construction. 
 (a) For purposes of this Agreement, whenever the context requires: the singular number shall include the
plural, and vice versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include the masculine and feminine genders. 

(b) Any rule of construction to the effect that ambiguities are to be resolved against the drafting party shall not be applied in the
construction or interpretation of this Agreement. 
 (c) The words “include” and “including,” and variations thereof,
shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words “without limitation.” 
 (d)
Except as otherwise indicated, all references in this Agreement to “Sections” and “Schedules” are intended to refer to Sections and Schedules to this Agreement. 

(e) The table of contents and headings contained in this Agreement are for reference purposes only and shall not affect in any way the meaning
or interpretation of this Agreement. 
 (f) References to “Dollars” and “$” mean dollars in lawful currency of the United
States of America. 
 (g) References to accounting terms shall be interpreted in accordance with GAAP unless otherwise specified. 

  
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 2. Registration Rights. The Company covenants and agrees as follows: 

2.1 Demand Registration. 

(a) Form S-1 Demand. If at any time one hundred eighty (180) days after the effective date of the
registration statement for the IPO, the Company receives a request from Holders of at least thirty-five percent (35%) of the Registrable Securities then outstanding that the Company file a Form S-1
registration statement with respect to at least thirty-five percent (35%) of the Registrable Securities then outstanding in which the anticipated aggregate offering price, net of Selling Expenses, would exceed $10 million, then the Company
shall (i) within ten (10) days after the date such request is given, give notice thereof (the “Demand Notice”) to all Holders other than the Initiating Holders and (ii) as soon as practicable, and in any event within
sixty (60) days after the date such request is given by the Initiating Holders, file a Form S-1 registration statement under the Securities Act covering all Registrable Securities that the Initiating
Holders requested to be registered and any additional Registrable Securities requested to be included in such registration by any other Holders, as specified by notice given by each such Holder to the Company within twenty (20) days of the date
the Demand Notice is given, and in each case, subject to the limitations of Sections 2.1(c) and 2.3. 
 (b) Form S-3 Demand. If at any time when it is eligible to use a Form S-3 registration statement, the Company receives a request from Holders of at least ten percent (10%) of the
Registrable Securities then outstanding that the Company file a Form S-3 registration statement with respect to outstanding Registrable Securities of such Holders having an anticipated aggregate offering
price, net of Selling Expenses, of at least $5 million, then the Company shall (i) within ten (10) days after the date such request is given, give a Demand Notice to all Holders other than the Initiating Holders and (ii) as soon
as practicable, and in any event within forty-five (45) days after the date such request is given by the Initiating Holders, file a Form S-3 registration statement under the Securities Act covering all
Registrable Securities requested to be included in such registration by any other Holders, as specified by notice given by each such Holder to the Company within twenty (20) days of the date the Demand Notice is given, and in each case, subject
to the limitations of Sections 2.1(c) and 2.3. 
 (c) Notwithstanding the foregoing obligations, if the Company furnishes to
Holders requesting a registration pursuant to this Section 2.1 a certificate signed by the Company’s chief executive officer stating that in the good faith judgment of the Board it would be materially detrimental to
the Company and its stockholders for such registration statement to either become effective or remain effective, then the Company shall have the right to defer taking action with respect to such filing, and any time periods with respect to filing or
effectiveness thereof shall be tolled correspondingly, for a period of not more than sixty (60) days after the request of the Initiating Holders is given; provided, however, that the Company may not invoke this right more than
twice in any twelve (12) month period (which may be for consecutive sixty (60) day periods aggregating to one hundred twenty (120) days); and provided further that the Company shall not register any securities or
instruments for its own account or that of any other stockholder during such period other than an Excluded Registration. 
 (d) The Company
shall not be obligated to effect, or to take any action to effect, any registration pursuant to Section 2.1(a) (i) during the period that is sixty (60) days before the Company’s good faith estimate of the
date of filing of, and ending on a date that is one hundred eighty (180) days after the effective date of, a Company-initiated registration, provided that the Company is actively employing in good faith commercially reasonable efforts to
cause such registration statement to become effective; (ii) after the Company has effected two registrations pursuant to Section 2.1(a) or (iii) if the Initiating Holders propose to dispose of shares of
Registrable Securities that may be immediately registered on Form S-3 pursuant to a request 

  
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made pursuant to Section 2.1(b). The Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to
Section 2.1(b) (A) during the period that is thirty (30) days before the Company’s good faith estimate of the date of filing of, and ending on a date that is ninety (90) days after the effective date of,
a Company-initiated registration, provided that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective or (B) if the Company has effected two registrations
pursuant to Section 2.1(b) within the twelve (12) month period immediately preceding the date of such request. A registration shall not be counted as “effected” for purposes of this
Section 2.1(d) until such time as the applicable registration statement has been declared effective by the SEC, unless the Initiating Holders withdraw their request for such registration, elect not to pay the registration
expenses therefor, and forfeit their right to one demand registration statement pursuant to Section 2.6, in which case such withdrawn registration statement shall be counted as “effected” for purposes of this
Section 2.1(d). 
 2.2 Piggyback Registration Rights. If the Company proposes to register (including, for
this purpose, a registration effected by the Company for stockholders other than the Holders) any of its Common Stock under the Securities Act in connection with the public offering of such securities solely for cash (other than in the IPO or an
Excluded Registration), the Company shall, at such time, promptly give each Holder notice of such registration. Upon the request of each Holder given within twenty (20) days after such notice is given by the Company, the Company shall, subject
to the provisions of Section 2.3, cause to be registered all of the Registrable Securities that each such Holder has requested to be included in such registration, provided, however, that a Stockholder may not invoke this
right more than once in any twelve (12) month period. The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 2.2 before the effective date of such registration, whether
or not any Holder has elected to include Registrable Securities in such registration. The expenses (other than Selling Expenses) of such withdrawn registration shall be borne by the Company in accordance with Section 2.6. 

2.3 Underwriting Requirements. 

(a) If, pursuant to Section 2.1, the Initiating Holders intend to distribute the Registrable Securities covered by
their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to Section 2.1, and the Company shall include such information in the Demand Notice. The underwriter(s)
will be selected by the Company and shall be reasonably acceptable to a majority in interest of the Initiating Holders. In such event, the right of any Holder to include such Holder’s Registrable Securities in such registration shall be
conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through
such underwriting shall (together with the Company as provided in Section 2.4(e)) enter into an underwriting agreement in customary form with the underwriter(s) selected for such underwriting. Notwithstanding any other
provision of this Section 2.3, if the underwriter(s) advise(s) the Initiating Holders in writing that marketing factors require a limitation on the number of shares to be underwritten, then the Initiating Holders shall so advise
all Holders of Registrable Securities that otherwise would be underwritten pursuant hereto, and the number of Registrable Securities that may be included in the underwriting shall be allocated among such Holders of Registrable Securities, including
the 

  
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Initiating Holders, in proportion (as nearly as practicable) to the number of Registrable Securities owned by each Holder or in such other proportion as shall mutually be agreed to by all such
selling Holders; provided, however, that the number of Registrable Securities held by the Holders to be included in such underwriting shall not be reduced unless all other securities are first entirely excluded from the underwriting.
To facilitate the allocation of shares in accordance with the above provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest one hundred (100) shares. 

(b) In connection with any offering involving an underwriting of shares of the Company’s capital stock pursuant to
Section 2.2, the Company shall not be required to include any of the Holders’ Registrable Securities in such underwriting unless the Holders accept the terms of the underwriting as agreed upon between the Company and
its underwriters, and then only in such quantity as the underwriters in their sole discretion determine will not jeopardize the success of the offering by the Company. If the total number of securities, including Registrable Securities, requested by
Stockholders to be included in such offering exceeds the number of securities to be sold (other than by the Company) that the underwriters in their reasonable discretion determine is compatible with the success of the offering, then the Company
shall be required to include in the offering only that number of such securities, including Registrable Securities, which the underwriters and the Company in their sole discretion determine will not jeopardize the success of the offering. If the
underwriters determine that less than all of the Registrable Securities requested to be registered can be included in such offering, then the Registrable Securities that are included in such offering shall be allocated among the selling Holders in
proportion (as nearly as practicable to) the number of Registrable Securities owned by each selling Holder or in such other proportions as shall mutually be agreed to by all such selling Holders. To facilitate the allocation of shares in accordance
with the above provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest one hundred (100) shares. Notwithstanding the foregoing, in no event shall (i) the number of Registrable
Securities included in the offering be reduced unless all other securities (other than securities to be sold by the Company) are first entirely excluded from the offering or (ii) the number of Registrable Securities included in the offering be
reduced below twenty percent (20%) of the total number of securities included in such offering, unless such offering is the IPO, in which case the selling Holders may be excluded further if the underwriters make the determination described above and
no other stockholder’s securities are included in such offering. For purposes of the provision in this Section 2.3(b) concerning apportionment, for any selling Holder that is a partnership, limited liability company or
corporation, the partners, members, retired partners, retired members, Stockholders, and Affiliates of such Holder, or the estates and Immediate Family Members of any such partners, retired partners, members and retired members, and any trusts for
the benefit of any of the foregoing Persons, shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” shall be based upon the aggregate number of Registrable Securities
owned by all Persons included in such “selling Holder,” as defined in this sentence. 
 (c) For purposes of
Section 2.1, a registration shall not be counted as “effected” if, as a result of an exercise of the underwriter’s cutback provisions in Section 2.3(a), fewer than fifty percent
(50%) of the total number of Registrable Securities that Holders have requested to be included in such registration statement are actually included. 

  
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 2.4 Obligations of the Company. Whenever required under this Section 2 to
effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible: 
 (a) prepare and file
with the SEC a registration statement with respect to such Registrable Securities and use its commercially reasonable efforts to cause such registration statement to become effective and, upon the request of the Holders of a majority of the
Registrable Securities registered thereunder, keep such registration statement effective for a period of up to one hundred twenty (120) days or, if earlier, until the distribution contemplated in the registration statement has been completed;
provided, however, that (i) such one hundred twenty (120) day period shall be extended for a period of time equal to the period the Holder refrains, at the request of an underwriter of Common Stock (or other securities) of
the Company, from selling any securities included in such registration and (ii) in the case of any registration of Registrable Securities on Form S-3 that are intended to be offered on a continuous or
delayed basis, subject to compliance with applicable SEC rules, such one hundred twenty (120) day period shall be extended for up to two hundred forty (240) days, if necessary, to keep the registration statement effective until all such
Registrable Securities are sold; 
 (b) prepare and file with the SEC such amendments and supplements to such registration statement, and the
prospectus used in connection with such registration statement, as may be necessary to comply with the Securities Act in order to enable the disposition of all securities covered by such registration statement; 

(c) furnish to the selling Holders such numbers of copies of a prospectus, including a preliminary prospectus, as required by the Securities
Act, and such other documents as the Holders may reasonably request in order to facilitate their disposition of their Registrable Securities; 

(d) use its commercially reasonable efforts to register and qualify the securities covered by such registration statement under such other
securities or blue-sky laws of such jurisdictions as shall be reasonably requested by the selling Holders; provided that the Company shall not be required to qualify to do business or to file a general
consent to service of process in any such states or jurisdictions, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 

(e) in the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and
customary form, with the underwriter(s) of such offering; 
 (f) use its commercially reasonable efforts to cause all such Registrable
Securities covered by such registration statement to be listed on a national securities exchange or trading system and each securities exchange and trading system (if any) on which similar securities issued by the Company are then listed; 

(g) provide a transfer agent and registrar for all Registrable Securities registered pursuant to this Agreement and provide a CUSIP number for
all such Registrable Securities, in each case not later than the effective date of such registration; 

  
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 (h) promptly make available for inspection by the selling Holders, any managing
underwriter(s) participating in any disposition pursuant to such registration statement, and any attorney or accountant or other agent retained by any such underwriter or selected by the selling Holders, all financial and other records, pertinent
corporate documents and properties of the Company, and cause the Company’s officers, directors, employees and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant or agent,
in each case, as necessary or advisable to verify the accuracy of the information in such registration statement and to conduct appropriate due diligence in connection therewith; 

(i) notify each selling Holder, promptly after the Company receives notice thereof, of the time when such registration statement has been
declared effective or a supplement to any prospectus forming a part of such registration statement has been filed; and 
 (j) after such
registration statement becomes effective, notify each selling Holder of any request by the SEC that the Company amend or supplement such registration statement or prospectus. 

In addition, the Company shall ensure that, at all times after any registration statement covering a public offering of securities of the
Company under the Securities Act shall have become effective, its insider trading policy shall provide that the Company’s directors may implement a trading program under Rule 10b5-1 of the Exchange Act.

 2.5 Furnish Information. It shall be a condition precedent to the obligations of the Company to take any action pursuant to this
Section 2 with respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the Registrable Securities held by it, and the intended method of disposition of
such securities as is reasonably required to effect the registration of such Holder’s Registrable Securities. 
 2.6 Expenses of
Registration. All expenses (other than Selling Expenses) incurred in connection with registrations, filings or qualifications pursuant to this Section 2, including all registration, filing and qualification fees; printers’ and
accounting fees; fees and disbursements of counsel for the Company; and the reasonable fees and disbursements, not to exceed $25,000, of one counsel for the selling Holders (“Selling Holder Counsel”), shall be borne and paid by the
Company; provided, however, that the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to Section 2.1 if the registration request is subsequently withdrawn at the request of
the Holders of a majority of the Registrable Securities to be registered (in which case all selling Holders shall bear such expenses pro rata based upon the number of Registrable Securities that were to be included in the withdrawn registration),
unless the Holders of a majority of the Registrable Securities agree to forfeit their right to one registration pursuant to Sections 2.1(a) or 2.1(b), as the case may be; provided further that if, at the time of such
withdrawal, the Holders shall have learned of a material adverse change in the condition, business or prospects of the Company from that known to the Holders at the time of their request and have withdrawn the request with reasonable promptness
after learning of such information then the Holders shall not be required to pay any of such expenses and shall not forfeit their right to one registration pursuant to Sections 2.1(a) or 2.1(b). All Selling Expenses relating to
Registrable Securities registered pursuant to this Section 2 shall be borne and paid by the Holders pro rata on the basis of the number of Registrable Securities registered on their behalf. 

  
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 2.7 Delay of Registration. No Holder shall have any right to obtain or seek an
injunction restraining or otherwise delaying any registration pursuant to this Agreement as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

2.8 Indemnification. If any Registrable Securities are included in a registration statement under this Section 2: 

(a) To the extent permitted by law, the Company will indemnify and hold harmless each selling Holder, and the partners, members, officers,
directors and stockholders of each such Holder; legal counsel and accountants for each such Holder; any underwriter (as defined in the Securities Act) for each such Holder; and each Person, if any, who controls such Holder or underwriter within the
meaning of the Securities Act or the Exchange Act, against any Damages, and the Company will pay to each such Holder, underwriter, controlling Person or other aforementioned Person any legal or other expenses reasonably incurred thereby in
connection with investigating or defending any claim or proceeding from which Damages may result, as such expenses are incurred; provided, however, that the indemnity agreement contained in this Section 2.8(a)
shall not apply to amounts paid in settlement of any such claim or proceeding if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable for any Damages to the
extent that they arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of any such Holder, underwriter, controlling Person or other aforementioned Person
expressly for use in connection with such registration. 
 (b) To the extent permitted by law, each selling Holder, severally and not
jointly, will indemnify and hold harmless the Company, and each of its directors, each of its officers who has signed the registration statement, each Person (if any), who controls the Company within the meaning of the Securities Act, legal counsel
and accountants for the Company, any underwriter (as defined in the Securities Act), any other Holder selling securities in such registration statement, and any controlling Person of any such underwriter or other Holder, against any Damages, in each
case only to the extent that such Damages arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of such selling Holder expressly for use in connection with such
registration; and each such selling Holder will pay to the Company and each other aforementioned Person any legal or other expenses reasonably incurred thereby in connection with investigating or defending any claim or proceeding from which Damages
may result, as such expenses are incurred; provided, however, that the indemnity agreement contained in this Section 2.8(b) shall not apply to amounts paid in settlement of any such claim or proceeding if such
settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; and provided further that in no event shall the aggregate amounts payable by any Holder by way of indemnity or contribution
under Sections 2.8(b) and 2.8(d) exceed the proceeds from the offering received by such Holder (net of any Selling Expenses paid by such Holder), except in the case of fraud or willful misconduct by such Holder. 

  
 12 

 (c) Promptly after receipt by an indemnified party under this
Section 2.8 of notice of the commencement of any action (including any governmental action) for which a party may be entitled to indemnification hereunder, such indemnified party will, if a claim in respect thereof is to be
made against any indemnifying party under this Section 2.8, give the indemnifying party notice of the commencement thereof. The indemnifying party shall have the right to participate in such action and, to the extent the
indemnifying party so desires, participate jointly with any other indemnifying party to which notice has been given, and to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an
indemnified party (together with all other indemnified parties that may be represented without conflict by one counsel) shall have the right to retain one separate counsel, with the fees and expenses to be paid by the indemnifying party, if
representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such
action. The failure to give notice to the indemnifying party within a reasonable time of the commencement of any such action shall relieve such indemnifying party of any liability to the indemnified party under this
Section 2.8, to the extent that such failure materially prejudices the indemnifying party’s ability to defend such action. The failure to give notice to the indemnifying party will not relieve it of any liability that
it may have to any indemnified party otherwise than under this Section 2.8. 
 (d) To provide for just and
equitable contribution to joint liability under the Securities Act in any case in which either: (i) any party otherwise entitled to indemnification hereunder makes a claim for indemnification pursuant to this
Section 2.8 but it is judicially determined (by the entry of a final judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such
indemnification may not be enforced in such case, notwithstanding the fact that this Section 2.8 provides for indemnification in such case or (ii) contribution under the Securities Act may be required on the part of
any party hereto for which indemnification is provided under this Section 2.8, then, and in each such case, such parties will contribute to the aggregate losses, claims, damages, liabilities or expenses to which they may be
subject (after contribution from others) in such proportion as is appropriate to reflect the relative fault of each of the indemnifying party and the indemnified party in connection with the statements, omissions or other actions that resulted in
such loss, claim, damage, liability or expense, as well as to reflect any other relevant equitable considerations. The relative fault of the indemnifying party and of the indemnified party shall be determined by reference to, among other things,
whether the untrue or allegedly untrue statement of a material fact, or the omission or alleged omission of a material fact, relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent,
knowledge, access to information and opportunity to correct or prevent such statement or omission; provided, however, that, in any such case (A) no Holder will be required to contribute any amount in excess of the public offering
price of all such Registrable Securities offered and sold by such Holder pursuant to such registration statement and (B) no Person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be
entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation; and provided further that in no event shall a Holder’s liability pursuant to this Section 2.8(d), when
combined with the amounts paid or payable by such Holder pursuant to Section 2.8(b), exceed the proceeds from the offering received by such Holder (net of any Selling Expenses paid by such Holder), except in the case of
willful misconduct or fraud by such Holder. 

  
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 (e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and
contribution contained in the underwriting agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 

(f) Unless otherwise superseded by an underwriting agreement entered into in connection with the underwritten public offering, the obligations
of the Company and Holders under this Section 2.8 shall survive the completion of any offering of Registrable Securities in a registration under this Section 2, and otherwise shall survive the
termination of this Agreement. 
 2.9 Reports Under Exchange Act. With a view to making available to the Holders the benefits of SEC
Rule 144 and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company shall: 

(a) make and keep available adequate current public information, as those terms are understood and defined in SEC Rule 144, at all times after
the effective date of the registration statement filed by the Company for the IPO; 
 (b) use commercially reasonable efforts to file with
the SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements); and 

(c) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) to the extent accurate, a
written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the registration statement filed by the Company for the IPO), the Securities
Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time
after the Company so qualifies); and (ii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC that permits the selling of any such securities without registration (at any time after
the Company has become subject to the reporting requirements under the Exchange Act) or pursuant to Form S-3 (at any time after the Company so qualifies to use such form). 

2.10 Limitations on Subsequent Registration Rights. From and after the date of this Agreement, the Company shall not, without the prior
written consent of (i) prior to the IPO, the Holders holding a majority of the shares of Series D Convertible Preferred Stock then held by the Holders or (ii) following the IPO, the Holders holding a majority of the
Registrable Securities then outstanding, enter into any agreement with any holder or prospective holder of any securities of the Company that allow such holder or prospective holder (a) to include such securities in any registration
unless, under the terms of such agreement, such holder or prospective holder may include such securities in any such registration only to the extent that the inclusion of such securities will not reduce the number of the Registrable Securities of
the Holders that are included or (b) allow such holder or prospective holder to initiate a demand for registration of any securities held by such holder or prospective holder; provided that this limitation shall not apply to any
Additional Stockholder. 

  
 14 

 2.11 “Market Stand-off” Agreement. Each Holder hereby agrees that it will
not, without the prior written consent of the managing underwriter, during the period commencing on the date of the final prospectus relating to the registration by the Company for its own behalf of shares of its Common Stock or any other equity
securities under the Securities Act on a registration statement on Form S-1 or Form S-3 in an underwritten offering, and ending on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty
(180) days), (i) Transfer, directly or indirectly, any shares of Common Stock or any securities convertible into or exercisable or exchangeable (directly or indirectly) for Common Stock owned by such Holder as of the date of the IPO or
(ii) enter into any swap or other arrangement that Transfers to another, in whole or in part, any of the economic consequences of ownership of such securities, whether any such transaction described in clause (i) or (ii)
above is to be settled by delivery of Common Stock or other securities, in cash or otherwise. The foregoing provisions of this Section 2.11 shall apply only to the IPO, shall be applicable to the Holders only if all officers, directors
and Stockholders owning at least 1% of the Common Stock on an as-converted basis are subject to the same restrictions, and shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement, or the Transfer of any
shares to any trust for the direct or indirect benefit of the Holder or the immediate family of the Holder, provided that the trustee of the trust agrees to be bound in writing by the restrictions set forth herein, and provided
further that any such Transfer shall not involve a disposition for value. The underwriters in connection with such registration are intended third-party beneficiaries of this Section 2.11 and shall have the right, power and
authority to enforce the provisions hereof as though they were a party hereto. Each Holder further agrees to execute such agreements as may be reasonably requested by the underwriters in connection with such registration that are consistent with
this Section 2.11 or that are necessary to give further effect thereto. Any discretionary waiver or termination of the restrictions set forth herein or in any agreement described in the preceding sentence shall be promptly disclosed in
writing by the Company to all Holders, and shall be deemed to apply to all such agreements on a pro rata basis based on the numbers of shares of Common Stock held by the Holders party to such agreements on an
as-converted basis. 
 2.12 Termination of Registration Rights. The right of any Holder to
request registration or inclusion of Registrable Securities in any registration pursuant to Sections 2.1 or 2.2 shall terminate upon the earliest to occur of: 

(a) the closing of a Sale of the Company; 

(b) such time as SEC Rule 144 or another similar exemption under the Securities Act is available for the sale of all of such Holder’s
shares without limitation during a three-month period without registration, except that the termination of registration rights set forth in this Section 2.12(b) shall not apply to any Holder of Registrable Securities who is
a director or executive officer of the Company; and 
 (c) the fifth (5th) anniversary
of the date of this Agreement. 

  
 15 

 3. Confidentiality. 

3.1 Confidentiality. Each Stockholder agrees that such Stockholder will keep confidential and will not disclose, divulge or use for any
purpose (other than (x) to monitor its investment in the Company or (y) in the case that a Stockholder is an employee of the Company, to act on behalf of the Company in such Stockholder’s capacity as an employee of the Company)
any confidential information obtained from the Company pursuant to the terms of this Agreement (including notice of the Company’s intention to file a registration statement), unless such confidential information (a) is known or
becomes known to the public in general (other than as a result of a breach of this Section 3.1 by such Stockholder), (b) is or has been independently developed or conceived by the Stockholder without use of the Company’s
confidential information or (c) is or has been made known or disclosed to the Stockholder by a third party without a breach of any obligation of confidentiality such third party may have to the Company; provided, however,
that an Stockholder may disclose confidential information (i) to its attorneys, accountants, consultants and other professionals to the extent necessary to obtain their services in connection with monitoring its investment in the
Company; (ii) to any prospective purchaser of any Voting Securities from such Stockholder, if such prospective purchaser agrees to be bound by the provisions of this Section 3.1 provided that such prospective purchaser
is not a Competitor; (iii) to any existing or prospective Affiliate, partner, member, stockholder or wholly owned subsidiary of such Stockholder in the ordinary course of business, provided that such Stockholder informs such
Person that such information is confidential and directs such Person to maintain the confidentiality of such information; or (iv) as may otherwise be required by law, provided that the Stockholder promptly notifies the Company of such
disclosure and takes reasonable steps to minimize the extent of any such required disclosure. 
 4. Voting Agreements. 

4.1 Voting Provisions Regarding Board of Directors. 

(a) Size of the Board. Each Stockholder (with respect to all shares of Voting Securities that such Stockholder owns or over which such
Stockholder otherwise exercises voting power) hereby agrees to vote, or cause to be voted, in person, by proxy or by action by written consent, as applicable, from time to time and at all times, in whatever manner as shall be necessary to ensure
that the size of the Board shall be set at the number of directors determined by the Board from time to time. 
 (b) Board
Composition. Each Stockholder (with respect to all shares of Voting Securities that such Stockholder owns or over which such Stockholder otherwise exercises voting power) hereby agrees to vote, or cause to be voted, in person, by proxy or by
action by written consent, as applicable, from time to time and at all times, in whatever manner as shall be necessary to ensure that at each annual or special meeting of Stockholders at which an election of directors is held or pursuant to any
written consent of the Stockholders, the following persons shall be elected to the Board: 
 (i) For so long as Sol J. Barer
holds shares of Common Stock or Preferred Stock, one individual designated by Sol J. Barer, which individual shall initially be Sol J. Barer; 

  
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 (ii) For so long as Isaac Blech holds shares of Common Stock or Preferred
Stock, one individual designated by Isaac Blech, which individual shall initially be Isaac Blech; 
 (iii) For so long as
InterWest Partners LP (the “InterWest Designee”) holds shares of Common Stock or Preferred Stock, one individual designated by the InterWest Designee, which individual shall initially be Arnold Oronsky; 

(iv) For so long as New Enterprise Associates 16, Limited Partnership (“NEA”) holds shares of Series D
Convertible Preferred Stock, one individual designated by NEA (the “NEA Designee”), which individual shall initially be Sara Nayeem; 

(v) For so long as Quan Venture Fund I, L.P. (“Quan”) holds shares of Series D Convertible Preferred Stock,
one individual designated by Quan and reasonably acceptable to the Board and NEA (the “Quan Designee”), which directorship shall initially be vacant; 

(vi) The Company’s Chief Executive Officer (the “CEO Director”), who shall initially be Jeffrey B.
Kindler, provided that if for any reason the CEO Director shall cease to serve as the Chief Executive Officer of the Company, each of the Stockholders shall promptly vote their respective shares (i) to remove the former Chief Executive
Officer from the Board if such person has not resigned as a member of the Board and (ii) to elect such person’s replacement as Chief Executive Officer of the Company as the new CEO Director; 

(vii) The Company’s Chief Scientific Officer (the “CSO Director”), who shall initially be James Campbell,
provided that if for any reason the CSO Director shall cease to serve as the Chief Scientific Officer of the Company, each of the Stockholders shall promptly vote their respective shares to remove the former Chief Scientific Officer from the
Board if such person has not resigned as a member of the Board; and 
 (viii) Subject to Sections 4.1(b)(i) through
(vii), any individual designated by the Board, one of which individual(s) shall initially be Shawn Tomasello. 
 To the extent that
any of clauses (i) through (vii) above shall not be applicable, any member of the Board who would otherwise have been designated in accordance with the terms thereof shall instead be designated by the Board. 

(c) Failure to Designate a Board Member. In the absence of any designation from the Persons or groups with the right to designate a
director as specified in Section 4.1(b), the director previously designated by them and then serving shall be reelected if still eligible to serve as provided herein. 

(d) Removal of Board Members. Each Stockholder also agrees to vote, or cause to be voted, all Voting Securities owned by such
Stockholder, or over which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to ensure that: 

  
 17 

 (i) subject to Section 4.1(e), no director elected
pursuant to Section 4.1(b) of this Agreement may be removed from office unless the Person(s) originally entitled to designate or approve such director or occupy such Board seat pursuant to
Section 4.1(b) is no longer so entitled to designate or approve such director or occupy such Board seat; 

(ii) any vacancies created by the resignation, removal or death of a director elected pursuant to
Section 4.1(b) shall be filled pursuant to the provisions of this Section 4.1; and 

(iii) upon the request of any party entitled to designate a director as provided in Section 4.1(b) to
remove such director, such director shall be removed. 
 All Stockholders agree to execute any written consents required to perform the obligations of this
Agreement, and the Company agrees at the request of any party entitled to designate directors to call a special meeting of Stockholders for the purpose of electing directors. 

(e) Removal of a Board Member for Cause. Each Stockholder (with respect to all shares of Voting Securities that such Stockholder owns or
over which such Stockholder otherwise exercises voting power) hereby agrees to vote, or cause to be voted, in person, by proxy or by action by written consent, as applicable, from time to time and at all times, in favor of removal of a director, and
hereby gives an irrevocable proxy to the Chairman of the Board and to the Chief Executive Officer of the Company, and each of them acting individually without the other, to vote such Stockholder’s shares to remove a director, if the Board,
after receiving advice of counsel, concludes that the director should be removed from the Board because either (a) the director could be removed for “cause” under then existing law or (b) disclosure should be made about the
director under Item 401(f) of the SEC’s Regulation S-K (relating to involvement in certain legal proceedings by directors, executive officers, promoters and control persons, a copy of which is attached
hereto as Annex A) or under common law relating to matters covered by Item 401(f) were the Company subject to the SEC’s the proxy rules and requirements. Such irrevocable proxy and all authority granted hereby shall be coupled with an interest
and therefore shall be irrevocable and shall not be terminated by any act such Stockholder. Such Stockholder agrees that, at the request of the Chairman of the Board or the Chief Executive Officer, he, she or it promptly will execute and deliver to
the Company a separate power of attorney on the same terms set forth in this Section 4.1(e), such execution to be witnessed and notarized, and in recordable form (if necessary). 

(f) No Liability for Election of Recommended Directors. No Stockholder, nor any Affiliate of any Stockholder, shall have any liability
as a result of designating a person for election as a director for any act or omission by such designated person in his or her capacity as a director of the Company, nor shall any Stockholder have any liability as a result of voting for any such
designee in accordance with the provisions of this Agreement. 
 4.2 Vote to Increase Authorized Common Stock. Each Stockholder (with
respect to all shares of Voting Securities that such Stockholder owns or over which such Stockholder otherwise exercises voting power) hereby agrees to vote or cause to be voted, in person, by proxy or by action by written consent, as applicable, in
whatever manner as shall be necessary to increase the number of authorized shares of Common Stock from time to time to ensure that there will be sufficient shares of Common Stock available for conversion of all of the shares of Preferred Stock
outstanding at any given time. 

  
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 4.3 Drag-Along Right. 

(a) Actions to be Taken. In the event that (i) the holders of (x) a majority in voting power of the shares Preferred Stock
held by the Stockholders and (y) a majority of the shares of Series D Convertible Preferred Stock held by the Stockholders (the “Selling Investors”); and (ii) the Board of Directors (collectively, the “Electing
Holders”) approve a Sale of the Company in writing, specifying that this Section 4.3 shall apply to such transaction, then each Stockholder and the Company hereby agree: 

(i) if such transaction requires stockholder approval, with respect to all Voting Securities that such Stockholder owns or over
which such Stockholder otherwise exercises voting power, to vote (in person, by proxy or by action by written consent, as applicable) all Voting Securities in favor of, and adopt, such Sale of the Company (together with any related amendment to the
Certificate of Incorporation required in order to implement such Sale of the Company) and to vote in opposition to any and all other proposals that could reasonably be expected to delay or impair the ability of the Company to consummate such Sale of
the Company; 
 (ii) if such transaction is a Stock Sale, to sell the same proportion of shares of capital stock of the
Company beneficially held by such Stockholder as is being sold by the Selling Investors to the Person to whom the Selling Investors propose to sell their Voting Securities, and, except as permitted in Section 4.3(b) below,
on the same terms and conditions as the Selling Investors; 
 (iii) to execute and deliver all related documentation and take
such other action in support of the Sale of the Company as shall reasonably be requested by the Company or the Selling Investors in order to carry out the terms and provision of this Section 4.3, including, without
limitation, executing and delivering instruments of conveyance and transfer, and any purchase agreement, merger agreement, indemnity agreement, escrow agreement, consent, waiver, governmental filing, share certificates duly endorsed for transfer
(free and clear of impermissible liens, claims and encumbrances), and any similar or related documents; 
 (iv) not to
deposit, and to cause their Affiliates not to deposit, except as provided in this Agreement, any Voting Securities of the Company owned by such party or Affiliate in a voting trust or subject any Voting Securities to any arrangement or agreement
with respect to the voting of such Voting Securities, unless specifically requested to do so by the acquiror in connection with the Sale of the Company; 

(v) to refrain from exercising any dissenters’ rights or rights of appraisal under applicable law at any time with respect
to such Sale of the Company; 

  
 19 

 (vi) if the consideration to be paid in exchange for the Voting Securities
pursuant to this Section 4.3 includes any securities and due receipt thereof by any Stockholder would require under applicable law (x) the registration or qualification of such securities or of any person as a broker
or dealer or agent with respect to such securities; or (y) the provision to any Stockholder of any information other than such information as a prudent issuer would generally furnish in an offering made solely to “accredited
investors” as defined in Regulation D promulgated under the Securities Act, the Company may cause to be paid to any such Stockholder in lieu thereof, against surrender of the Voting Securities which would have otherwise been sold by such
Stockholder, an amount in cash equal to the fair value (as determined in good faith by the Company) of the securities which such Stockholder would otherwise receive as of the date of the issuance of such securities in exchange for the Voting
Securities; and 
 (vii) in the event that the Selling Investors, in connection with such Sale of the Company, appoint a
stockholder representative (the “Stockholder Representative”) with respect to matters affecting the Stockholders under the applicable definitive transaction agreements following consummation of such Sale of the Company, (x) to
consent to (i) the appointment of such Stockholder Representative, (ii) the establishment of any applicable escrow, expense or similar fund in connection with any indemnification or similar obligations, and (iii) the payment of such
Stockholder’s pro rata portion (from the applicable escrow or expense fund or otherwise) of any and all reasonable fees and expenses to such Stockholder Representative in connection with such Stockholder Representative’s services and
duties in connection with such Sale of the Company and its related service as the representative of the Stockholders, and (y) not to assert any claim or commence any suit against the Stockholder Representative or any other Stockholder with
respect to any action or inaction taken or failed to be taken by the Stockholder Representative in connection with its service as the Stockholder Representative, absent fraud or willful misconduct. 

(b) Exceptions. Notwithstanding the foregoing, a Stockholder will not be required to comply with
Section 4.3(a) above in connection with any proposed Sale of the Company (the “Proposed Sale”), unless: 

(i) any representations and warranties to be made by such Stockholder in connection with the Proposed Sale are limited to
representations and warranties related to authority, ownership and the ability to convey title to such Shares, including, but not limited to, representations and warranties that (a) the Stockholder holds all right, title and interest in and to
the Shares such Stockholder purports to hold, free and clear of all liens and encumbrances, (b) the obligations of the Stockholder in connection with the transaction have been duly authorized, if applicable, (c) the documents to be entered
into by the Stockholder have been duly executed by the Stockholder and delivered to the acquirer and are enforceable against the Stockholder in accordance with their respective terms, and (d) neither the execution and delivery of documents to
be entered into in connection with the transaction, nor the performance of the Stockholder’s obligations thereunder, will cause a breach or violation of the terms of any agreement, law or judgment, order or decree of any court or governmental
agency; 
 (ii) such Stockholder shall not be liable for the inaccuracy of any representation or warranty made by any other
Person in connection with the Proposed Sale, other than the Company (except to the extent that funds may be paid out of an escrow established to cover breach of representations, warranties and covenants of the Company as well as breach by any
stockholder of any of identical representations, warranties and covenants provided by all stockholders); 

  
 20 

 (iii) the liability for indemnification, if any, of such Stockholder in the
Proposed Sale and for the inaccuracy of any representations and warranties made by the Company or its Stockholders in connection with such Proposed Sale, is several and not joint with any other Person (except to the extent that funds may be paid out
of an escrow established to cover breach of representations, warranties and covenants of the Company as well as breach by any stockholder of any of identical representations, warranties and covenants provided by all stockholders), and subject to the
provisions of the Certificate of Incorporation related to the allocation of the escrow, is pro rata in proportion to, and does not exceed, the amount of consideration paid to such Stockholder in connection with such Proposed Sale; and 

(iv) upon the consummation of the Proposed Sale (i) each holder of each class or series of the Company’s stock will
receive the same form of consideration for their shares of such class or series as is received by other holders in respect of their shares of such same class or series of stock, (ii) each holder of a series of Preferred Stock will receive the
same amount of consideration per share of such series of Preferred Stock as is received by other holders in respect of their shares of such same series, (iii) each holder of Common Stock will receive the same amount of consideration per share
of Common Stock as is received by other holders in respect of their shares of Common Stock, and (iv) unless the holders of a majority of the shares of Common Stock then issued or issuable upon conversion of the shares of Preferred Stock (to
include the holders of a majority of the shares of Common Stock then issued or issuable upon conversion of the shares of Series D Convertible Preferred Stock) elect to receive a lesser amount by written notice given to the Company at least ten
(10) days prior to the effective date of any such Proposed Sale, the aggregate consideration receivable by all holders of the Preferred Stock and Common Stock shall be allocated among the holders of Preferred Stock and Common Stock on the basis
of the relative liquidation preferences to which the holders of each respective series of Preferred Stock and the holders of Common Stock are entitled in a Deemed Liquidation Event (assuming for this purpose that the Proposed Sale is a Deemed
Liquidation Event) in accordance with the Company’s Certificate of Incorporation in effect immediately prior to the Proposed Sale; provided, however, that, notwithstanding the foregoing, if the consideration to be
paid in exchange for the Key Holder Voting Securities or Preferred Stock, as applicable, pursuant to this Section 4.3(b)(iv) includes any securities and due receipt thereof by any Key Holder or holder of Preferred Stock
would require under applicable law (x) the registration or qualification of such securities or of any person as a broker or dealer or agent with respect to such securities; or (y) the provision to any Key Holder or holder of Preferred
Stock of any information other than such information as a prudent issuer would generally furnish in an offering made solely to “accredited investors” as defined in Regulation D promulgated under the Securities Act, the Company may cause to
be paid to any such Key Holder or holder of Preferred Stock in lieu thereof, against surrender of the Key Holder Voting Securities or Preferred Stock, as applicable, which would have otherwise been sold by such Key Holder or holder of Preferred
Stock, an amount in cash equal to the fair value 

  
 21 

 
(as determined in good faith by the Company) of the securities which such Key Holder or holder of Preferred Stock would otherwise receive as of the date of the issuance of such securities in
exchange for the Key Holder Voting Securities or Preferred Stock, as applicable. 
 (c) Restrictions on Sales of Control of the
Company. No Stockholder shall be a party to any Stock Sale unless all holders of Preferred Stock are allowed to participate in such transaction and the consideration received pursuant to such transaction is allocated among the parties thereto in
the manner specified in the Company’s Certificate of Incorporation in effect immediately prior to the Stock Sale (as if such transaction were a Deemed Liquidation Event), unless the holders of a majority in voting power of the Preferred Stock
then outstanding and the holders of a majority of the Series D Convertible Preferred Stock then outstanding elect otherwise by written notice given to the Company at least 10 days prior to the effective date of any such transaction or series of
related transactions. 
 4.4 Termination of Voting Rights. The covenants set forth in this Section 4 shall terminate and be of
no further force and effect (a) immediately before the consummation of the IPO, (b) when the Company first becomes subject to the periodic reporting requirements of Section 12(g) or 15(d) of the Exchange Act or
(c) upon a Sale of the Company, whichever event occurs first. 
 5. Additional Covenants and Agreements. 

5.1 Restrictions on Transfer. 

(a) The Voting Securities shall not be Transferred, and the Company shall not recognize and shall issue stop-transfer instructions to its
transfer agent with respect to any such Transfer, except upon the conditions specified in this Agreement, which conditions are intended to ensure compliance with the provisions of the Securities Act. A transferring Holder will cause any proposed
transferee of the Voting Securities held by such Holder to agree to take and hold such Voting Securities subject to the provisions and upon the conditions specified in this Agreement. 

(b) Each certificate or instrument representing the Voting Securities shall be stamped or otherwise imprinted with a legend substantially in
the following form: 
 THE SECURITIES REPRESENTED HEREBY HAVE BEEN ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933. SUCH SHARES MAY NOT BE SOLD, PLEDGED, OR TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR A VALID EXEMPTION FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SAID ACT. 

  
 22 

 THE SECURITIES REPRESENTED HEREBY MAY BE TRANSFERRED ONLY IN ACCORDANCE WITH THE TERMS OF
THE CENTREXION THERAPEUTICS CORPORATION THIRD AMENDED AND RESTATED STOCKHOLDERS AGREEMENT, DATED AS OF DECEMBER 18, 2017, AMONG THE COMPANY, EACH STOCKHOLDER PARTY THERETO, AS MAY BE AMENDED FROM TIME TO TIME, A COPY OF WHICH IS ON FILE WITH
THE SECRETARY OF THE COMPANY. 
 The Holders consent to the Company making a notation in its records and giving instructions to any transfer
agent of the Voting Securities in order to implement the restrictions on Transfer set forth in this Section 5.1. 

(c) The Holder of each certificate representing Voting Securities, by acceptance thereof, agrees to comply in all respects with the provisions
of this Section 5.1. Before any proposed Transfer of any Voting Securities, unless there is in effect a registration statement under the Securities Act covering the proposed transaction, the Holder thereof shall give notice
to the Company of such Holder’s intention to effect such Transfer. Each such notice shall describe the manner and circumstances of the proposed Transfer in sufficient detail and, if reasonably requested by the Company, shall be accompanied at
such Holder’s expense by either (i) a written opinion of legal counsel who shall, and whose legal opinion shall, be reasonably satisfactory to the Company, addressed to the Company, to the effect that the proposed transaction may be
effected without registration under the Securities Act, (ii) a “no action” letter from the SEC to the effect that the proposed Transfer of such Voting Securities without registration will not result in a recommendation by the staff of
the SEC that action be taken with respect thereto or (iii) any other evidence reasonably satisfactory to counsel to the Company to the effect that the proposed Transfer of the Voting Securities may be effected without registration under the
Securities Act, whereupon the Holder of such Voting Securities shall be entitled to Transfer such Voting Securities in accordance with the terms of the notice given by the Holder to the Company. The Company will not require such a legal opinion or
“no action” letter (A) in any transaction in compliance with SEC Rule 144 or (B) in any transaction in which such Holder distributes Voting Securities to an Affiliate of such Holder for no consideration; provided that each
transferee agrees in writing to be subject to the terms of this Section 5.1. Each certificate or instrument evidencing the Voting Securities Transferred as above provided shall bear, except if such Transfer is made pursuant
to SEC Rule 144, the appropriate restrictive legend set forth in Section 5.1(b). 
 (d) None of the Stockholders
may Transfer any shares of Common Stock or Preferred Stock to any Person that is not an “accredited investor,” as defined in Rule 501 under the Securities Act. 

5.2 Tag-along Rights. If a Selling Stockholder proposes to sell any of its shares of Common Stock to an independent third party, the
Stockholders that hold Series D Convertible Preferred Stock and Series C Convertible Preferred Stock shall be permitted to participate in such sale on the terms and conditions set forth in this Section 5.2. 

  
 23 

 (a) Prior to the consummation of the sale described above, the Selling Stockholder shall
deliver to the Company and each other Holder a Sale Notice no more than ten (10) Business Days after the execution and delivery by all parties thereto of the definitive agreement entered into with respect to the sale, and, in any event, no
later than twenty (20) Business Days prior to the closing date of the proposed sale. The Sale Notice shall make reference to the tag-along rights hereunder and shall describe in reasonable detail
(i) the number of shares of Common Stock to be sold by the Selling Stockholder, (ii) the name of the Proposed Transferee; (iii) the per share purchase price and the other material terms and conditions of the sale, including a
description of any non-cash consideration in sufficient detail to permit the valuation thereof; (iv) the proposed date, time and location of the closing of the sale; and (v) a copy of any form of
agreement proposed to be executed in connection therewith. 
 (b) Shares to be Sold. 

(i) Each Tag-along Stockholder shall exercise its right to participate in a sale of
Common Stock by the Selling Stockholder subject to this Section 5.2 by delivering to the Selling Stockholder a Tag-along Notice stating its election to do so and specifying the number
of shares of Common Stock to be sold by it no later than five Business Days after receipt of the Sale Notice. The offer of each Tag-along Stockholder set forth in a
Tag-along Notice shall be irrevocable, and, to the extent such offer is accepted, such Tag-along Stockholder shall be bound and obligated to sell in the proposed sale on
the terms and conditions set forth in this Section 5.2. Each Tag-along Stockholder shall have the right to sell in a sale subject to this Section 5.2 the
number of shares of Common Stock equal to the product obtained by multiplying (x) the number of shares of Common Stock held by the Tag-along Stockholder by (y) a fraction (A) the numerator of
which is equal to the number of shares of Common Stock the Selling Stockholder proposes to sell or transfer to the Proposed Transferee and (B) denominator of which is equal to the number of shares of Common Stock then owned by such Selling
Stockholder. 
 (ii) The Selling Stockholder shall use its commercially reasonable efforts to include in the proposed sale to
the Proposed Transferee all of the shares of Common Stock that the Tag-along Stockholders have requested to have included pursuant to the applicable Tag-along Notices,
it being understood that the Proposed Transferee shall not be required to purchase shares of Common Stock in excess of the number set forth in the Sale Notice. In the event the Proposed Transferee elects to purchase less than all of the shares of
Common Stock sought to be sold by the Tag-along Stockholders, the number of shares to be sold to the Proposed Transferee by the Selling Stockholder and each Tag-along
Stockholder shall be reduced so that each such Stockholder is entitled to sell its Pro Rata Portion of the number of shares of Common Stock the Proposed Transferee elects to purchase (which in no event may be less than the number of shares of Common
Stock set forth in the Sale Notice). 
 (iii) Each Tag-along Stockholder who does not
deliver a Tag-along Notice in compliance with clause (i) above shall be deemed to have waived all of such Tag-along Stockholder’s rights to participate in such
sale, and the Selling Stockholder shall (subject to the rights of any participating Tag-along Stockholder) thereafter be free to sell to the Proposed Transferee its shares of Common Stock at a per share price
that is no greater than the per share price set forth in the Sale Notice and on other same terms and conditions which are not materially more favorable to the Selling Stockholder than those set forth in the Sale Notice, without any further
obligation to the non-accepting Tag-along Stockholders. 

  
 24 

 (c) Consideration. Each Tag-along Stockholder
participating in a sale pursuant to this Section 5.2 shall receive the same consideration per share after deduction of such Tag-along Stockholder’s proportionate share of the
related expenses in accordance with Section 5.2(e). 
 (d) Conditions of Sale. Each Tag-along Stockholder shall make or provide the same representations, warranties, covenants, indemnities and agreements as the Selling Stockholder makes or provides in connection with the Tag-along Sale (except that in the case of representations, warranties, covenants, indemnities and agreements pertaining specifically to the Selling Stockholder, the Tag-along
Stockholder shall make the comparable representations, warranties, covenants, indemnities and agreements pertaining specifically to itself); provided, that all representations, warranties, covenants and indemnities shall be made by the
Selling Stockholder and each other Tag-along Stockholder severally and not jointly and any indemnification obligation in respect of breaches of representations and warranties that do not relate to such Tag-along Stockholder shall be in an amount not to exceed the aggregate proceeds received by such Tag-along Stockholder in connection with any sale consummated pursuant to
this Section 5.2. 
 (e) Expenses. The fees and expenses of the Selling Stockholder incurred in connection
with a sale under this Section 5.2 and for the benefit of all participating Stockholders (it being understood that costs incurred by or on behalf of the Selling Stockholder for its sole benefit will not be considered to be
for the benefit of all participating Stockholders), to the extent not paid or reimbursed by the Company or the Proposed Transferee, shall be shared by all participating Stockholders on a pro rata basis, based on the consideration received by each
Stockholder; provided, that no Stockholder shall be obligated to make any out-of-pocket expenditure prior to the consummation of the transaction consummated
pursuant to this Section 5.2. 
 (f) Cooperation. Each Tag-along
Stockholder shall take all actions as may be reasonably necessary to consummate the Tag-along Sale, including, without limitation, entering into agreements and delivering certificates and instruments, in each
case, consistent with the agreements being entered into and the certificates being delivered by the Selling Stockholder. 
 (g) Deadline
for Completion of Sale. The Selling Stockholder shall have 90 Business Days following the expiration of the Tag-along Period in which to sell the shares of Common Stock described in the Sale Notice, on
terms not more favorable to the Selling Stockholder than those set forth in the Sale Notice (which such 90 Business Day period may be extended for a reasonable time not to exceed 120 Business Days to the extent reasonably necessary to obtain any
regulatory approvals). If at the end of such period the Selling Stockholder has not completed such sale, the Selling Stockholder may not then effect a sale of Common Stock subject to this Section 5.2 without again fully
complying with the provisions of this Section 5.2. 

  
 25 

 (h) Sales in Violation of the Tag-along Rights. If the Selling
Stockholder sells or otherwise transfers to the Proposed Transferee any of its shares of Common Stock in breach of this Section 5.2, then each Tag-along Stockholder shall have the
right to sell to the Selling Stockholder, and the Selling Stockholder undertakes to purchase from each Tag-along Stockholder, the number of shares of Common Stock that such
Tag-along Stockholder would have had the right to sell to the Proposed Transferee pursuant to this Section 5.2, for a per share amount and form of consideration and upon the terms and
conditions on which the Proposed Transferee bought such Common Stock from the Selling Stockholder, but without indemnity being granted by any Tag-along Stockholder to the Selling Stockholder; provided,
that nothing contained in this Section 5.2 shall preclude any Tag-along Stockholder from seeking alternative remedies against such Selling Stockholder as a result of its breach of
this Section 5.2. The Selling Stockholder shall also reimburse each Tag-along Stockholder for any and all reasonable and documented out-of-pocket fees and expenses, including reasonable legal fees and expenses, incurred pursuant to the exercise or the attempted exercise of the Tag-along
Stockholder’s rights under this Section 5.2(h). 
 5.3 Termination of Certain
Covenants. The covenants set forth in Sections 5.1 and 5.2 shall terminate and be of no further force or effect (a) immediately before the consummation of the IPO or (b) when the Company first becomes
subject to the periodic reporting requirements of Section 12(g) or 15(d) of the Exchange Act or (c) upon a Sale of the Company, whichever event occurs first. 

5.4 Series C Warrants. For the avoidance of doubt, each holder of a Series C Warrant (as defined below) acknowledges and agrees that the
Series C Warrants are exercisable only for shares of the Company’s Series C Convertible Preferred Stock (and no other class or series of capital stock of the Company) pursuant to the terms and conditions thereof and shall not be exercisable for
shares issued in any Qualified Financing (as defined in the Series C Warrants) other than the Qualified Financing that consisted of the issuance of the Company’s Series C Convertible Preferred Stock. For purposes of this
Section 5.4, the “Series C Warrants” shall mean the warrants to purchase securities of the Company issued to various parties together with those certain unsecured convertible promissory notes dated
March 1, 2016, April 8, 2016, April 29, 2016 and June 14, 2016. 
 6. Miscellaneous. 

6.1 Successors and Assigns. The rights under this Agreement may be assigned (but only with all related obligations) by a Holder to a
transferee of Voting Securities that (a) is an Affiliate of a Holder or (b) is a Holder’s Immediate Family Member or trust for the benefit of an individual Holder or one or more of such Holder’s Immediate Family Members;
provided, however, that (i) the Company is, within a reasonable time after such Transfer, furnished with written notice of the name and address of such transferee and the Voting Securities with respect to which such rights
are being Transferred and (ii) such transferee agrees in a written instrument delivered to the Company to be bound by and subject to the terms and conditions of this Agreement, including the provisions of Section 2.11. For
the purposes of determining the number of shares of Voting Securities held by a transferee, the holdings of a transferee (A) that is an Affiliate or stockholder of a Holder, (B) who is a Holder’s Immediate Family Member
or (C) that is a trust for the benefit of an individual Holder or such Holder’s Immediate Family Member shall be aggregated together and with those of the transferring Holder; provided further that all transferees who
would not qualify individually for assignment of rights shall have a single attorney-in-fact for the purpose of exercising any rights, receiving notices or taking any action 

  
 26 

 
under this Agreement. The terms and conditions of this Agreement inure to the benefit of and are binding upon the respective successors and permitted assignees of the parties. Nothing in this
Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and permitted assignees any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as
expressly provided herein. 
 6.2 Governing Law. This Agreement and the rights and obligations of the parties hereto shall be
governed, construed and interpreted in all respects in accordance with the General Corporation Law of the State of Delaware as to matters governed by such General Corporation Law, and as to all other matters in accordance with the laws of the
Commonwealth of Massachusetts without regard to its choice of laws principles. 
 6.3 Counterparts. This Agreement may be executed in
two (2) or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf or any
electronic signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective
for all purposes. 
 6.4 Titles and Subtitles. The titles and subtitles used in this Agreement are for convenience only and are
not to be considered in construing or interpreting this Agreement. 
 6.5 Notices. All notices and other communications given or made
pursuant to this Agreement shall be in writing and shall be deemed effectively given upon the earlier of actual receipt or (a) personal delivery to the party to be notified; (b) when sent, if sent by electronic mail during the
recipient’s normal business hours, and if not sent during normal business hours, then on the recipient’s next business day; (c) five (5) days after having been sent by registered or certified mail, return receipt requested,
postage prepaid or (d) one (1) business day after the business day of deposit with a nationally recognized overnight courier, freight prepaid, specifying next-day delivery, with written verification of receipt. All communications shall
be sent to the respective parties at their addresses as set forth on the signature pages hereto or the Purchase Agreement or in the Company’s records, or to the principal office of the Company and to the attention of the Chief Executive
Officer, in the case of the Company, or to such email address or address as subsequently modified by written notice given in accordance with this Section 6.5. 

6.6 Amendments, Terminations and Waivers. Any term of this Agreement may be amended or terminated, and the observance of any term of
this Agreement may be waived (either generally or in a particular instance, and either retroactively or prospectively) only with the written consent of (X) prior to the IPO, (a) the Company and (b) the Holders holding a
majority of shares of Series D Convertible Preferred Stock then held by the Holders and (Y) following the IPO (a) the Company and (b) the Holders holding a majority of the Registrable Securities then outstanding,
provided that (i) the Company may in its sole discretion waive compliance with Sections 5.1(b) or (c) (and the Company’s failure to object promptly in writing after notification of a proposed Transfer allegedly in violation
of Sections 5.1(b) or (c) shall be deemed to be a waiver) and (ii) that any provision hereof may be waived by any waiving party on such party’s own behalf, without the consent of any other party. Notwithstanding
the foregoing, this 

  
 27 

 
Agreement may not be amended or terminated and the observance of any term hereof may not be waived with respect to any Stockholder without the written consent of such Stockholder, unless such
amendment, termination or waiver applies to all Stockholders in the same fashion. Notwithstanding any other provision of this Agreement, (1) neither Section 4.1(b)(i) nor this subclause (1) shall be amended or
waived without the written consent of Sol Barer so long as Sol Barer is entitled to designate a director under Section 4.1(b)(i); (2) neither Section 4.1(b)(ii) nor this subclause (2) shall be
amended or waived without the written consent of Isaac Blech so long as Isaac Blech is entitled to designate a director under Section 4.1(b)(ii); (3) neither Section 4.1(b)(iii) nor this subclause
(3) shall be amended or waived without the written consent of InterWest Partners LP so long as InterWest Partners LP is entitled to designate a director under Section 4.1(b)(iii); (4) neither Section 4.1(b)(iv)
nor this subclause (4) shall be amended or waived without the written consent of NEA so long as NEA is entitled to designate a director under Section 4.1(b)(iv); (5) neither Section 4.1(b)(v)
nor this subclause (5) shall be amended or waived without the written consent of Quan and NEA so long as Quan is entitled to designate a director under Section 4.1(b)(v); and (6) neither Section 4.1(b)(vi)
nor this subclause (6) shall be amended or waived without the written consent of Jeffrey Kindler so long as Jeffrey Kindler is the CEO Director. The Company shall give prompt notice of any amendment or termination hereof or waiver hereunder to
any party hereto that did not consent in writing to such amendment, termination or waiver. Any amendment, termination or waiver effected in accordance with this Section 6.6 shall be binding on all parties hereto, regardless
of whether any such party has consented thereto. No waivers of or exceptions to any term, condition or provision of this Agreement, in any one or more instances, shall be deemed to be or construed as a further or continuing waiver of any such term,
condition or provision. 
 6.7 Severability. In case any one or more of the provisions contained in this Agreement is for any reason
held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provision of this Agreement, and such invalid, illegal or unenforceable provision shall be reformed and construed
so that it will be valid, legal and enforceable to the maximum extent permitted by law. 
 6.8 Aggregation of Stock. All shares of
Voting Securities held or acquired by Affiliates shall be aggregated together for the purpose of determining the availability of any rights under this Agreement and such Affiliated persons may apportion such rights as among themselves in any manner
they deem appropriate. 
 6.9 Additional Stockholders. Notwithstanding anything to the contrary contained herein, if the Company
issues additional shares of Voting Securities after the date of this Agreement, any purchaser of such shares of Voting Securities may become a party to this Agreement by executing and delivering an additional counterpart signature page to this
Agreement, and thereafter shall be deemed a “Stockholder” for all purposes hereunder. No action or consent by the Stockholders shall be required for such joinder to this Agreement by such Additional Stockholder, so long as such Additional
Stockholder has agreed in writing to be bound by all of the obligations as a “Stockholder” hereunder. 

  
 28 

 6.10 Entire Agreement. This Agreement (including any hereto) constitutes the full and
entire understanding and agreement among the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject matter hereof existing between the parties is expressly cancelled. Each Stockholder
(including an Additional Stockholder) party hereto acknowledges that his Agreement shall be binding upon such Stockholder in respect of the Common Stock, Preferred Stock and any other equity of the Company held by such Stockholder even if less than
all of the stockholders of the Company execute and deliver this Agreement. 
 6.11 Dispute Resolution. 

(a) The parties (i) hereby irrevocably and unconditionally submit to the jurisdiction of the state courts of Massachusetts and to the
jurisdiction of the United States District Court for the District of Massachusetts and in any Massachusetts State Court sitting in Suffolk County, Commonwealth of Massachusetts for the purpose of any suit, action or other proceeding arising out of
or based upon this Agreement, (ii) agree not to commence any suit, action or other proceeding arising out of or based upon this Agreement except in the United States District Court for the District of Massachusetts and in any Massachusetts
State Court sitting in Suffolk County, Commonwealth of Massachusetts and (iii) hereby waive, and agree not to assert, by way of motion, as a defense or otherwise, in any such suit, action or proceeding, any claim that it is not subject
personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding
is improper or that this Agreement or the subject matter hereof may not be enforced in or by such court. 
 (b) WAIVER OF JURY TRIAL: EACH
PARTY HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, THE OTHER TRANSACTION DOCUMENTS, THE SECURITIES OR THE SUBJECT MATTER HEREOF OR THEREOF. THE SCOPE OF THIS WAIVER IS INTENDED
TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT AND THAT RELATE TO THE SUBJECT MATTER OF THIS TRANSACTION, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING
NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS SECTION HAS BEEN FULLY DISCUSSED BY EACH OF THE PARTIES HERETO AND THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER
WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND THAT SUCH PARTY KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 

6.12 Delays or Omissions. No delay or omission to exercise any right, power or remedy accruing to any party under this Agreement, upon
any breach or default of any other party under this Agreement, shall impair any such right, power or remedy of such nonbreaching or nondefaulting party, nor shall it be construed to be a waiver of or acquiescence to any such breach or default, or to
any similar breach or default thereafter occurring, nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. All remedies, whether under this Agreement or by law or
otherwise afforded to any party, shall be cumulative and not alternative. 

  
 29 

 6.13 Acknowledgment. The Company acknowledges that the Stockholders may be in the
business of venture capital investing and therefore review the business plans and related proprietary information of many enterprises, including enterprises which may have products or services which compete directly or indirectly with those of the
Company. Nothing in this Agreement shall preclude or in any way restrict the Stockholders from investing or participating in any particular enterprise whether or not such enterprise has products or services which compete with those of the Company.

 6.14 Effect on Prior Agreement. Upon the execution and delivery of this Agreement by the Company and the Requisite Stockholders,
the Prior Agreement automatically shall be of no further force and effect and shall be amended and restated in its entirety to read as set forth in this Agreement. 

[Remainder of Page Intentionally Left Blank] 

  
 30 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	CENTREXION THERAPEUTICS CORPORATION
		
	By:	 	/s/ Jeffrey B. Kindler
	Name:	 	Jeffrey B. Kindler
	Title:	 	Chief Executive Officer

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

	
	KEY HOLDERS:
	
	/s/ Sol J. Barer
	Sol J. Barer
	
	/s/ Isaac Blech
	Isaac Blech
	
	/s/ Jeffrey B. Kindler
	Jeffrey B. Kindler

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	New
		
		 	AAR Associates, L.P.
		 	(Name of Entity)
			
		 	By:	 	/s/ Ralph Finerman
		 	Name:	 	Ralph Finerman
		 	Title:	 	General Partner

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	 
		 	Address:	 	[***]
		 		 	[***]

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	ACB HOLDINGS LP
		 	(Name of Entity)
			
		 	By:	 	/s/ Adam C. Blum
		 	Name:	 	ADAM C. BLUM
		 	Title:	 	MANAGER OF THROCKMORTON MANAGEMENT, LLC, GENERAL PARTNER

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	                                
        
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	ACNYC, LLC
		 	(Name of Entity)
			
		 	By:	 	/s/ Andrew Cader
		 	Name:	 	Andrew Cader
		 	Title:	 	Managing Member

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	                                
        
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                                
        
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Leonard H. Adelson
		 	Name:	 	LEONARD H. ADELSON
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Gilya Alchits
		 	Name:	 	Gilya Alchits
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Nigel V. Alexander
		 	Name:	 	 NIGEL V. ALEXANDER

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Monte D Anglin /s/ Janet S Anglin
		 	Name:	 	 Monte D Anglin & Janet S Anglin

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 AR Properties

		 	(Name of Entity)
			
	*	 	By:	 	 /s/ Dennis Repp

		 	Name:	 	 Dennis Repp

		 	Title:	 	 Gen Ptr

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	ARROWMARK FUNDAMENTAL OPPORTUNITY FUND, L.P.
		
	By:	 	its Investment Advisor
		 	ArrowMark Colorado Holdings, LLC
		
	By:	 	/s/ David Corkins
	Name:	 	David Corkins
	Title:	 	Managing Member

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Barclay Armitage
		 	Name:	 	 Barclay Armitage

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 AVAVODHA, INC.

		 	(Name of Entity)
			
		 	By:	 	 /s/ Mark Ast

		 	Name:	 	 MARK AST

		 	Title:	 	 President

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Robert L. Bahr
		 	Name:	 	 Robert L. Bahr

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 The Bahr Family Limited
Partnership

		 	(Name of Entity)
			
		 	By:	 	 /s/ Robert L. Bahr

		 	Name:	 	 Robert L. Bahr

		 	Title:	 	 Trustee of the General
Partner

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	/s/ Sol J. Barer
	Sol J. Barer
		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	BARER & SONS LLC
		
	By:	 	/s/ Sol J. Barer
	Name:	 	Sol J. Barer
	Title:	 	Partner

 
			
		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Martin Becker
		 	Name:	 	 MARTIN BECKER

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name;	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Stephen Bender
		 	Name;	 	 Stephen Bender

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Franklin M. Berger
		 	Name:	 	 FRANKLIN M. BERGER

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 BES Investments LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Jeffrey Enslin

		 	Name:	 	 Jeffrey Enslin

		 	Title:	 	 Manager

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Blairoma, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Arthur J. Simon

		 	Name:	 	 Arthur J. Simon

		 	Title:	 	 Director

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	/s/ Isaac Blech
	Isaac Blech
		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	                    
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	RIVER CHARITABLE REMAINDER UNIT TRUST FBO ISAAC BLECH U/A/D 7/20/87
		
	By:	 	/s/ Isaac Blech
	Name:	 	Isaac Blech
	Title:	 	Trustee

 
			
		
	Address:	 	                                
            
	 
	 

 
			
		
	Email Address:	 	                    
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 The Irwin Blitt Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Joel Bayer

		 	Name:	 	 Joel Bayer

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Richard I. Bowling Jr.
		 	Name:	 	 Richard I. Bowling Jr.

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Roger D. Bozarth
		 	Name:	 	 Roger D. Bozarth

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	BRADLEY RESOURCES COMPANY LLC
		
	By:	 	 /s/ G W Holbrook

	Name:	 	G W Holbrook
	Title:	 	President, CEO

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	/s/ Kerrie Brady
	 Kerrie Brady

		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Charles F. Brinkley
		 	Name:	 	 Charles F. Brinkley

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Franklin D. Brown
		 	Name:	 	 Franklin D. Brown

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Graham Burton
		 	Name:	 	 GRAHAM BURTON

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	JAMES N. CAMPBELL 2012 DYNASTY TRUST
		
	By:	 	/s/ Regina Anderson
	Name:	 	REGINA ANDERSON
	Title:	 	
		
	By:	 	 
	Name:	 	
	Title:	 	

 
			
		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	JAMES N. CAMPBELL 2012 DYNASTY TRUST
		
	By:	 	/s/ Louis F. Friedman
	Name:	 	LOUIS F. FRIEDMAN
	Title:	 	 TRUSTEE

		
	By:	 	 
	Name:	 	
	Title:	 	

 
			
		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	/s/ James N. Campbell
	James N. Campbell

 
			
		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	STOCKHOLDER:
	
	/s/ James N. Campbell
	James N. Campbell, as joint tenant
	
	/s/ Regina Anderson
	Regina Anderson, as joint tenant

 
			
		
	Address:	 	[***]
	 
	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Adolfo Carmona / /s/ Donna Carmona
		 	Name:	 	 Adolfo and Donna Carmona

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	CF ASCENT LLC
		
	By:	 	/s/ David Corkins
	Name:	 	David Corkins
	Title:	 	Managing Member

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Chih-Kai Cheng
		 	Name:	 	 Chih-Kai Cheng

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	CLOUGH HEALTHCARE MASTER FUND, L.P.
		
	By:	 	Clough Capital Partners L.P., its investment advisor
		
	By:	 	/s/ Daniel J. Gillis
	Name:	 	Daniel Gillis
	Title:	 	Chief Compliance Officer

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	CLOUGH GLOBAL EQUITY FUND
		
	By:	 	Clough Capital Partners L.P., its investment advisor
		
	By:	 	/s/ Daniel J. Gillis
	Name:	 	Daniel Gillis
	Title:	 	Chief Compliance Officer

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	CLOUGH GLOBAL OPPORTUNITIES FUND
		
	By:	 	Clough Capital Partners L.P., its investment advisor
		
	By:	 	/s/ Daniel J. Gillis
	Name:	 	Daniel Gillis
	Title:	 	Chief Compliance Officer

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                    
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Marc A. Cohen
		 	Name:	 	MARC A. COHEN
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                                

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Michael Cohn /s/ Paula Cohn
		 	Name:	 	Michael Cohn and Paula Cohn
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Mark H. Coleman
		 	Name:	 	MARK H. COLEMAN
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ David S. Cooper
		 	Name:	 	David S. Cooper
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                    
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Charles J. Costich /s/ Karin J. Costich
		 	Name:	 	Charles and Karin Costich
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                    
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Ben Crown
		 	Name:	 	Ben Crown
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                    
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Stephen D’Antonio
		 	Name:	 	Stephen D’Antonio
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
		
		 	        The Jonathan Davis Trust
			
		 	By:	 	                    
		 	Name	 	 
		 	Title:	 	 
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Jonathan Davis
		 	Name	 	  

		 	Address:	 	  

		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                    
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Michael Dan
		 	Name:	 	Michael Dan
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ C Barnes Darwin, II
		 	Name:	 	C BARNES DARWIN, II
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                    
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Patrick deCavaignac
		 	Name:	 	Patrick deCavaignac
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ David Dent
		 	Name:	 	DAVID DENT
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 DIANA AND DAVID FRESHWATER LIVING TRUST

		 	(Name of Entity)
			
		 	By:	 	/s/ David Freshwater
		 	Name:	 	DAVID FRESHWATER
		 	Title:	 	TRUSTEE

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ James M. Diasio
		 	Name:	 	James M. Diasio
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ James T. Dietz
		 	Name:	 	James T. Dietz
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Rollyn P. Dritz
		 	Name	 	Rollyn P. Dritz
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Russell S. Dietz
		 	Name:	 	Russell S. Dritz
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Juli-Ann Cialone
		 	Name:	 	Juli-Ann Cialone
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Alyson D. Schlosser
		 	Name	 	Alyson D. Schlosser
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ James L. Dritz
		 	Name:	 	James L. Dritz
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Paul Ehrlich CPA Defined Benefit Plan

		 	(Name of Entity)
			
		 	By:	 	/s/ Paul Ehrlich
		 	Name:	 	Paul Ehrlich
		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Paul Ehrman
		 	Name:	 	Paul Ehrman
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	EFUNG RUIBO LIMITED
		
	By:	 	/s/ Zhu Jin Qiao
	Name:	 	Zhu Jin Qiao
	Title:	 	Corporate Representative

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 E.L. II Properties Trust dtd July 1, 1983

		 	(Name of Entity)            as amended
			
		 	By:	 	/s/ Robert C. Kopple
		 	Name:	 	Robert C. Kopple
		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ George Elefther /s/ Karin Elefther
		 	Name:	 	George Elefther/Karin Elefther
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Ron Eller /s/ Beth Eller
		 	Name:	 	Ron and Beth Eller
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Adrien Ellul
		 	Name:	 	Adrien Ellul
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Daniel Erlanger /s/ Beth Erlanger
		 	Name:	 	Daniel and Beth Erlanger
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	EZMM&B HOLDINGS, LLC,
		 	 A DELAWARE LIMITED LIABILITY COMPANY

		 	(Name of Entity)
			
		 	By:	 	 
		 	Name:	 	BRYAN EZRALOW AS TRUSTEE OF THE
		 	Title:	 	BRYAN EZRALOW 1994 TRUST U/T/D/ 12.22.1994 MANAGER AND MEMBER

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	EZ COLONY PARTNERS, LLC,
		 	 A DELAWARE LIMITED LIABILITY COMPANY

		 	(Name of Entity)
			
		 	By:	 	 
		 	Name:	 	BRYAN EZRALOW AS TRUSTEE OF THE
		 	Title:	 	BRYAN EZRALOW 1994 TRUST U/T/D/ 12.22.1994 MANAGER AND MEMBER

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 F3F S.P.A.

		 	(Name of Entity)
			
		 	By:	 	/s/ Laura Iris Ferro
		 	Name:	 	Laura Iris Ferro
		 	Title:	 	Chairman

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Faith Family Holdings, LP

		 	(Name of Entity)
			
		 	By:	 	/s/ Robert A. Faith
		 	Name:	 	Robert A. Faith
		 	Title:	 	Managing General Partner

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Steven Farber
		 	Name:	 	Steven Farber
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Gary M. Ferman
		 	Name:	 	Gary M. Ferman
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ William Filon
		 	Name:	 	William Filon
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Trevor Fetter
		 	Name:	 	Trevor Fetter
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Cynthia Finerman Living Trust
		 	(Name of Entity)
			
		 	By:	 	/s/ Cynthia Finerman
		 	Name:	 	Cynthia Finerman
		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Ralph Finerman
		 	Name:	 	Ralph Finerman
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Donald A. Fishbein
		 	Name:	 	Donald A. Fishbein
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Fortezza Investments L.P.

		 	(Name of Entity)
			
		 	By:	 	/s/ Michael Marocco
		 	Name:	 	Michael Marocco
		 	Title:	 	Managing Member of Fortezza Capital Management, its general partner

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Peter Friedland
		 	Name:	 	Peter Friedland
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ David L. Frydrych
		 	Name:	 	David L. Frydrych
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Michael J. Gahan
		 	Name:	 	Michael J. Gahan
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Garfinkle Revocable Trust

		 	(Name of Entity)
			
		 	By:	 	/s/ Morris Garfinkle
		 	Name:	 	Morris Garfinkle
		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Keith J. Gelles
		 	Name:	 	Keith Gelles
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Albert Gentile /s/ Hiedi Gentile
		 	Name:	 	Albert Gentile/Hiedi Gentile
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 GH HEALTHLINK CAPITAL LIMITED

		 	(Name of Entity)
			
		 	By:	 	/s/ Lau Yuen Yee, Sam
		 	Name:	 	Lau Yuen Yee, Sam
		 	Title:	 	Director

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name:	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	            
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Steven Gladstone
		 	Name:	 	Steven Gladstone
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:    12.14.2017
		
		 	/s/ Laura K. Goethe / /s/ Bruce D. Goethe
		 	Name:	 	 Bruce D. and Laura K. Goethe

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Jeffrey E. Goldman
		 	Name:	 	 Jeffrey E. Goldman

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Robert K Green Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Robert K Green

		 	Name:	 	 Robert K Green

		 	Title:	 	 Managing General Partner

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Robert K Green
		 	Name:	 	 Robert K Green

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ William F. Grieco
		 	Name:	 	 William F. Grieco

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Robert P. Giesen
		 	Name:	 	 Robert P. Giesen

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Nathan Halegua
		 	Name:	 	 
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	            
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Timothy P. Hanley /s/ Monica Hanley
		 	Name:	 	 Timothy P. Hanley/Monica Hanley

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ William H. Harris
		 	Name:	 	 William H. Harris

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Henry Herzing Revocable Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Henry Herzing

		 	Name:	 	 Henry Herzing

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 HG Phanstiel, LP

		 	(Name of Entity)
			
		 	By:	 	 /s/ Howard G. Phanstiel

		 	Name:	 	 Howard G. Phanstiel

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Joel L. Hochman Rev. Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Joel L. Hochman

		 	Name:	 	 Joel L. Hochman

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	  

		 	(Name of Entity)
			
		 	By:	 	  

		 	Name:	 	  

		 	Title:	 	  

	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Evan B. Azriliant
		 	Name:	 	Evan B. Azriliant
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
		 	(Name of Entity)
			
		 	By:	 	  

		 	Name:	 	  

		 	Title:	 	  

	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Timothy Hogue
		 	Name:	 	Timothy Hogue
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
             

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Thomas Huang
		 	Name:	 	Thomas Huang
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
             

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ William Huff
                                12/13/17
		 	Name:	 	William Huff
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
		 	STOCKHOLDER:
		
		 	Interwest Investors VIII, LP
			
		 	By:	 	 /s/ Arnold Oronsky

		 	Name:	 	 Arnold Oronsky

		 	Title:	 	 Managing Director

					
			
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
		 	STOCKHOLDER:
		
		 	Interwest Investors Q VIII, LP
			
		 	By:	 	 /s/ Arnold Oronsky

		 	Name:	 	 Arnold Oronsky

		 	Title:	 	 Managing Director

					
			
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
		 	STOCKHOLDER:
		
		 	Interwest Partners VIII, LP
			
		 	By:	 	 /s/ Arnold Oronsky

		 	Name:	 	 Arnold Oronsky

		 	Title:	 	 Managing Director

					
			
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
		 	STOCKHOLDER:
		
		 	Interwest Partners IX, LP
			
		 	By:	 	 /s/ Arnold Oronsky

		 	Name:	 	 Arnold Oronsky

		 	Title:	 	 Managing Director

					
			
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
                 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Bruce P. Inglis + Maney M. Inglis JTWROS
		 	Name:	 	Bruce P. Inglis + Maney M. Inglis JTWROS
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
         

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Marc R. Jalbert
		 	Name:	 	Marc R. Jalbert
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
         

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Robert C. Jamo
		 	Name:	 	Robert C. Jamo
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Edgar D. Jannotta, Jr. Exempt Family
Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Erika C. Pearsall

		 	Name:	 	 Erika C. Pearsall

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 JPM Partners, LP

		 	(Name of Entity)
			
		 	By:	 	 /s/ John W. Puth

		 	Name:	 	 John W. Puth

		 	Title:	 	 General Partner

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 JLB Family Trust

		 	(Name of Entity)
		
		 	Premier Trust, Inc., Trustee
			
		 	By:	 	 /s/ Brian Simmons

		 	Name:	 	 Brian Simmons

		 	Title:	 	 SVP/Trust Officer

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Brandon Jones
		 	Name:	 	Brandon Jones
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Kala International Investment Co
Ltd.

		 	(Name of Entity)
			
		 	By:	 	 /s/ Rong XIAO

		 	Name:	 	 Rong XIAO

		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 William M. Kargman Revocable Trust UAD

12/02/2009

		 	(Name of Entity)
			
		 	By:	 	 /s/ William M. Kargman

		 	Name:	 	 William M. Kargman

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Marjie B. Kargman Robert M. Kargman,
		 	Name:	 	 Marjie B. Kargman Robert M.

Kargman, JTWROS

		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 RM Kargman 2012 Life Insurance
Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Edward J. Bartlett, Jr.

		 	Name:	 	 Edward J. Bartlett, Jr.

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Katanick Family Limited
Partnership

		 	(Name of Entity)
			
		 	By:	 	 /s/ Jaye Katanick

		 	Name:	 	 Jaye Katanick

		 	Title:	 	 Pres

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	                

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Gary Katzmann
		 	Name:	 	Gary Katzmann
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 CM Loeb Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Thomas Kempner

		 	Name:	 	 Thomas Kempner

		 	Title:	 	 Chairman & CEO of Loeb Holding
Corp.

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Thomas Kempner
		 	Name:	 	Thomas Kempner
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
		
		 	STOCKHOLDER:
		
		 	/s/ Jeffrey B. Kindler
		 	Address:	 	[***]        
		 	                         
                       
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Trust for Descendants of Charles &
Elizabeth
 Kontulis UAD 1/27/10

		 	(Name of Entity)
			
		 	By:	 	 /s/ Martha F. Morse

		 	Name:	 	 Martha F. Morse

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)

 
					
			
		 	By:	 	 

 
					
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Thomas C. Kotyk
		 	Name:	 	Thomas C. Kotyk
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name	 	 
		 	Title:	 	 
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Klaus Kretschmer
		 	Name	 	Klaus Kretschmer
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 L & Co., LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ James E. Lineberger, Jr.

		 	Name:	 	 James E. Lineberger, Jr.

		 	Title:	 	 Member

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	                
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Lagom LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Marika Lindholm

		 	Name:	 	 Marika Lindholm

		 	Title:	 	 Manager

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	                

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Roger Lash
		 	Name:	 	Roger Lash
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 

		 	Name	 	 
		 	Title:	 	 
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Holler Liepmann
		 	Name:	 	Holler Liepmann
		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 James E. Lineberger Revocable
Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ James E. Lineberger

		 	Name:	 	 James E. Lineberger

		 	Title:	 	 Trustee

	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	        
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	LEERINK HOLDINGS LLC
		
	By:	 	 /s/ Joseph R. Gentile

	Name:	 	Joseph R. Gentile
	Title:	 	CAO

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	LEERINK SWANN CO-INVESTMENT FUND, LLC
		
	By:	 	 /s/ Joseph R. Gentile

	Name	 	Joseph R. Gentile
	Title:	 	Manager

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	LOOKFAR INVESTMENTS, LLC
		
	By:	 	 /s/ David Corkins

	Name:	 	David Corkins
	Title:	 	Managing Member

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 /s/ Steven K. Luminais

		 	Name:	 	 Steven K. Luminais

		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 /s/ Elizabeth K. Luminais

		 	Name:	 	 Elizabeth K. Luminais 

		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	    Estate of William L. Lurie
		
		 	 /s/ Rita M. Lurie

		 	Name:	 	 Rita M. Lurie Executrix

		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 /s/ Rick D. Mace

		 	Name:	 	 Rick D. Mace

		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 /s/ Charles J. Magolske

		 	Name:	 	 Charles J. Magolske

		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Mai 2, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Brian Finn

		 	Name:	 	 Brian Finn

		 	Title:	 	 Administrator

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Stanley M. Marks
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 MARSHALL S. EZRALOW ROTH IRA

		 	(Name of Entity)
			
		 	By:	 	 /s/ Marshall S. Ezralow

		 	Name:	 	 Marshall S. Ezralow

		 	Title:	 	 Participant

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Robert Masters
		 	Name:	 	Robert Masters
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	MERIDIAN SMALL CAP GROWTH FUND
		
	By:	 	its Investment Advisor ArrowMark Colorado Holdings, LLC
		
	By:	 	/s/ David Corkins
	Name:	 	David Corkins
	Title:	 	Managing Member

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Stephen J. Meringoff
		 	Name:	 	Stephen J. Meringoff
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Arthur F. Michaelis
		 	Name:	 	Arthur F. Michaelis
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Christine Renee Monks
		 	Name:	 	 Christine Renee Monks

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Montauk, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ William Laverack, Jr.

		 	Name:	 	 William Laverack, Jr.

		 	Title:	 	 Managing Member

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ James Moonier
		 	Name:	 	 James Moonier

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	                         
                           
		 	(Name of Entity)
			
		 	By:	 	                                
                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Reed Moskowitz
		 	Name:	 	 Reed Moskowitz

		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
                                     

		 	Name	 	
                   
                                     

		 	Title:	 	
                   
                                 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Michael Mullins
		 	Name:	 	                                
                        
		 	Address:	 	[***]
		 	 

 
					
	
	Email Address: [***]
	
	Phone Number: [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
                                 

		 	Name	 	 
		 	Title:	 	
                   
                                 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Mitchell L. Mutter
		 	Name:	 	 Mitchell L. Mutter

		 	Address:	 	 [***]

		 	 

 
					
	
	Email Address: [***]
	
	Phone Number: [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
                         

		 	Name	 	
                   
                                 

		 	Title:	 	
                   
                                 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 /s/ Robert M. Newsome

		 	Name:	 	 Robert M. Newsome

		 	Address:	 	 [***]

		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	NEW ENTERPRISE ASSOCIATES 16, L.P.
	
	By: NEA Partners 16, L.P., its general partner
	
	By: NEA 16 GP, LLC, its general partner
		
	By:	 	 /s/ Louis S.
Citron                        

	Name:	 	Louis S. Citron
	Title:	 	Chief Legal Officer
		
	Address:	 	[***]
	
	NEA VENTURES 2017, Limited Partnership
		
	By:	 	 /s/ Louis S. Citron

	Name:	 	Louis S. Citron
	Title:	 	Vice-President
		
	Address:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Northlea Partners

		 	(Name of Entity)
			
		 	By:	 	 /s/ John H Abeles MD

		 	Name	 	 John H Abeles MD

		 	Title:	 	 Manager of General Partner

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 [***]

		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Northstar Consulting, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ William K Schmidt, PhD

		 	Name:	 	 William K Schmidt, PhD

		 	Title:	 	 President

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 The Notas Family Trust

		 	(Name of Entity)
			
		 	By:	 	 /s/ Bernard Notas

		 	Name:	 	 Bernard Notas

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 The Oaks Family, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Robert Kargman

		 	Name	 	 Robert Kargman,

		 	Title:	 	 Manager duly authorized

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Oakwood Capital, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Kurt G. Conti

		 	Name:	 	 Kurt G. Conti

		 	Title:	 	 President

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 The Oberkfell Living Trust dtd
12/18/02

		 	(Name of Entity)
			
		 	By:	 	 H. F. Oberkfell

		 	Name:	 	 H. F. Oberkfell

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	/s/ Karin O. Brainard
		
		 	 
			
		 	Name(s):	 	Karin O. Brainard
		 		 	    (please print)

 
					
			
		 	Title:	 	 
		 		 	(if Stockholder is not an individual)
			
		 	Address:	 	 
		
		 	 
		
		 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Josh & Julie Ofman Family Trust
		 	(Name of Entity)
			
		 	By:	 	/s/ Josh Ofman
		 	Name:	 	 Josh Ofman

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	/s/ David R. Olson
		
		 	 
			
		 	Name(s):	 	David R. Olson
		 		 	    (please print)
			
		 	Title:	 	 
		 		 	(if Stockholder is not an individual)
			
		 	Address:	 	[***]
		 	 
		 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Stanford Baratz Rev. Trust
		 	(Name of Entity)
			
		 	By:	 	/s/ Stanford Baratz
		 	Name:	 	Stanford Baratz
		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                            
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Isaac Blech
		 	Name:	 	Isaac Blech
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Presdio Partners 2007, L.P.
		 	(Name of Entity)
		 	Presido Partners 2007 GP, L.P., its general partner
		 	Presidio Partners 2007 GP, LLC, its general partner
			
		 	By:	 	/s/ David J. Collier
		 	Name:	 	David J. Collier
		 	Title:	 	Managing Director

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                    
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Presidio Partners 2007 (Parallel), L.P.
		 	(Name of Entity)
		 	Presidio Partners 2007 (Parallel), GP, L.P., its general partner
		 	Presidio Partners 2007 (Parallel), GP, LLC, its general partner
			
		 	By:	 	/s/ David J. Collier
		 	Name:	 	David J. Collier
		 	Title:	 	Managing Director

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
 
		 	Name	 	                    
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	                        
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Michael P. Ross
		 	Name:	 	Michael P. Ross
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
     

		 	(Name of Entity)
			
		 	By:	 	
                   
     

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Matthew Orlando
		 	Name:	 	Matthew Orlando
		 	Address:	 	[***]
		 	

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	OSI Holdings LLC
		 	(Name of Entity)
			
		 	By:	 	/s/ Kevin P. McCarthy
		 	Name:	 	Kevin P. McCarthy
		 	Title:	 	President and Member

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)

 
					
		
		 	    STOCKHOLDER:

 
					
		
		 	 Osprey I, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Dale Burns

		 	Name:	 	 Dale Burns

		 	Title:	 	 Manager

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Gregg P. Otto
		 	Name:	 	Gregg P. Otto Jeanne G. Otto
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Panella Living Trust dtd 5/11/2004
		 	(Name of Entity)
			
		 	By:	 	/s/ Joseph A Panella
		 	Name:	 	Joseph A Panella
		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name:	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)

 
					
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Jonathan P. Patronik
		 	Name:	 	Jonathan P. Patronik
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)

 
					
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Paul G. Roberts
		 	Name:	 	Paul G. Roberts
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Andrew L. Perito
		 	Name:	 	Andrew L. Perito
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Edward V. Pershing
		 	Name:	 	Edward V. Pershing
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Daniel Petro
		 	Name:	 	Daniel Petro
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 
		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Neal Polan
		 	Name:	 	Neal Polan
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Brian Potiker Revocable Trust UAD 8/7/96
		 	(Name of Entity)
			
		 	By:	 	/s/ Brian Potiker
		 	Name:	 	Brian Potiker
		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	  STOCKHOLDER:

 
					
		
		 	 
		 	Name	 	 
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
         

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Robert C. Pozen
		 	Name:	 	Robert C. Pozen
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	David EI Pyott Living Trust
		 	(Name of Entity)
			
		 	By:	 	/s/ David EI Pyott
		 	Name:	 	David EI Pyott
		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	QUAN VENTURE FUND I, L.P.
		
	By:	 	Quan Venture Partners I, L.L.C.
		
	Its:	 	General Partner
		
	By:	 	/s/ Marietta Wu
	Name:	 	Marietta Wu
	Title:	 	Managing Director

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Stephen R. Quazzo Trust dated 11/9/95
		 	(Name of Entity)
			
		 	By:	 	/s/ Stephen R. Quazzo
		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	James B. Ramo Revocable Trust
		 	(Name of Entity)
			
		 	By:	 	/s/ James Ramo
		 	Name:	 	James Ramo
		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
         

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Todd A. Rathe
		 	Name:	 	Todd A. Rathe
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Rehoboth Hundred LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Joseph Ruggiero

		 	Name:	 	 Joseph J. Ruggiero

		 	Title:	 	 Managing Partner

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
     

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Mark Reutlinger Analee P. Reutlinger
		 	Name:	 	Mark & Analee P. Reutlinger
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
     

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Michael Rieber
		 	Name:	 	Michael Rieber
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Stephen E. Riffee Rev Trust
		 	(Name of Entity)
			
		 	By:	 	 /s/ Stephen E. Riffee

		 	Name:	 	 Stephen E. Riffee

		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	River Charitable Remainder Trust
		 	(Name of Entity)
			
		 	By:	 	 /s/ Isaac Blech

		 	Name:	 	Isaac Blech
		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Rockledge Associates, LLC
		 	(Name of Entity)
			
		 	By:	 	 /s/ Richard A. Bernstein

		 	Name:	 	 Richard A. Bernstein

		 	Title:	 	Managing Member

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
     

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Jeff Roberts
		 	Name:	 	Jeff Roberts
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Dyke Rogers
		 	Name:	 	Dyke Rogers
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ T. Mark Rogstad
		 	Name:	 	T. Mark Rogstad
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
     

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Ken Rosenblum /s/ Ann Simonds
		 	Name:	 	Ken Rosenblum and Ann Simonds
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Mark Ross
		 	Name:	 	Mark Ross
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	 /s/ Steven Rothstein MD

		 	Name:	 	 Steven Rothstein MD

		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Marc A. Rotter
		 	Name:	 	Marc A. Rotter
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Lisa Rudes Grandchildren Trust
		 	(Name of Entity)
			
		 	By:	 	 /s/ Lisa Rudes Sandel

		 	Name:	 	Lisa Rudes Sandel
		 	Title:	 	 Trustee

 

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Rudes GCT Investment Partnership

		 	(Name of Entity)
			
		 	By:	 	 /s/ Lisa Rudes Sandel

		 	Name:	 	 Lisa Rudes Sandel

		 	Title:	 	 President

					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
                       
		 	Name	 	                                
                
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	                
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
                                 

		 	(Name of Entity)
			
		 	By:	 	
                   
                     

		 	Name	 	
                   
                             

		 	Title:	 	
                   
             

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Philip T. Ruegger
		 	Name:	 	Philip T. Ruegger
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
                                 

		 	(Name of Entity)
			
		 	By:	 	
                   
                     

		 	Name	 	
                   
                             

		 	Title:	 	
                   
             

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Peter D. Schiffrin
		 	Name:	 	Peter D. Schiffrin
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
                                 

		 	(Name of Entity)
			
		 	By:	 	
                   
                     

		 	Name	 	
                   
                             

		 	Title:	 	
                   
             

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ David Schneider
		 	Name:	 	David Schneider
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Shamus, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ David E. Smith

		 	Name:	 	 David E. Smith

		 	Title:	 	 President of Coast Asset Management, LLC,

its trading advisor

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
               
		 	Name	 	                                

		 	Address:	 	                        
		 	 

 
			
		
	Email Address:	 	                                

		
	Phone Number:	 	
                   
             

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 Shanghai Healthcare Industry Investment
Fund/New
 York, LLC

		 	(Name of Entity)
			
		 	By:	 	 /s/ Sun Feng

		 	Name:	 	 Sun Feng

		 	Title:	 	 CEO

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	                         
               
		 	Name	 	                                

		 	Address:	 	                        
		 	 

 
			
		
	Email Address:	 	                                

		
	Phone Number:	 	
                   
             

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
                     

		 	(Name of Entity)
			
		 	By:	 	
                   
             

		 	Name	 	
                   
                     

		 	Title:	 	
                

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Dennis Shasha
		 	Name:	 	Dennis Shasha
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
                     

		 	(Name of Entity)
			
		 	By:	 	
                   
             

		 	Name	 	
                   
                     

		 	Title:	 	
                

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ William Sheppard
		 	Name:	 	William Sheppard
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
                     

		 	(Name of Entity)
			
		 	By:	 	
                   
             

		 	Name	 	
                   
                     

		 	Title:	 	
                

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Richard A Smith
		 	Name:	 	Richard A Smith
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	
                   
                     

		 	(Name of Entity)
			
		 	By:	 	
                   
             

		 	Name	 	
                   
                     

		 	Title:	 	
                

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Bryan Spille
		 	Name:	 	Bryan Spille
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	 [***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Starlight Investment Holdings Limited
		 	(Name of Entity)
			
		 	By:	 	 /s/ Nicola Hodge

		 	Name:	 	 Nicola Hodge

		 	Title:	 	Director

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	
                   
 

		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Lawrence D. Stern 2010 Qualified Annuity Trust
		 	(Name of Entity)
			
		 	By:	 	 /s/ Rebecca A. M. Stern

		 	Name:	 	 Rebecca A. M. Stern

		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	
                   
 

		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Randall M. Stevens
		 	Name:	 	Randall M. Stevens
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ William Strawbridge
		 	Name:	 	William Strawbridge
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Clayton A. Struve
		 	Name:	 	Clayton A. Struve
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	THB IRON ROSE, LLC LIFE SCIENCE PORTFOLIO
		
	By:	 	 its Investment Advisor
 ArrowMark Colorado
Holdings, LLC

		
	By:	 	 /s/ David Corkins

	Name:	 	David Corkins
	Title:	 	Managing Member

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	THB IRON ROSE, LLC
		
	By:	 	its Investment Advisor
		 	ArrowMark Colorado Holdings, LLC
		
	By:	 	 /s/ David Corkins

	Name:	 	David Corkins
	Title:	 	Managing Member

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ James W. Thomas
		 	Name:	 	James W. Thomas
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
		
		 	STOCKHOLDER:
		
		 	/s/ Shawn Tomasello
		 	Shawn Tomasello
			
		 	Address:	 	[***]
		 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Terrence E. Troy
		 	Name:	 	Terrence E. Troy
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name:	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Carleen A. Tufo
		 	Name:	 	Carleen A. Tufo
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	United Acquisition Corp.
		 	(Name of Entity)
			
		 	By:	 	 /s/ John A. Catsimatidis

		 	Name:	 	 John A. Catsimatidis

		 	Title:	 	Chairman and CEO

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	                        
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Arnold Ursaner
		 	Name:	 	Arnold Ursaner
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Steve Valko
		 	Name:	 	Steve Valko
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
 

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ John V. Wagner
		 	Name:	 	John V. Wagner
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Neil H. Wasserman
		 	Name:	 	Neil H. Wasserman
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Steven J. Wice
		 	Name:	 	Steven J. Wice
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Howard J. Workman
		 	Name:	 	Howard J. Workman
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

	
	 /s/ Tony Yao

	Tony Yao

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ illegible
		 	Name:	 	 
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Steven and Kaye Yost Family Trust
		 	(Name of Entity)
			
		 	By:	 	 /s/ Steven Yost 

		 	Name:	 	Steven Yost
		 	Title:	 	Trustee
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	 
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Steven Yost Roth IRA
		 	(Name of Entity)
			
		 	By:	 	 /s/ Steven Yost 

		 	Name:	 	 Steven Yost 

		 	Title:	 	Roth IRA Owner
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	 
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Henry M. Zachs
		 	Name:	 	Henry M. Zachs
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ George Zelinski
		 	Name:	 	George Zelinski
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	The Irrevocable Aloha Trust UAD 05/01/2002
		 	(Name of Entity)
			
		 	By:	 	 /s/ Marianne Schmitt Hellauer 

		 	Name:	 	 Marianne Schmitt Hellauer 

		 	Title:	 	Trustee
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	 
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Seymour H. Block Defined Benefit Plan
		 	(Name of Entity)
			
		 	By:	 	 /s/ Seymour H. Block 

		 	Name:	 	 Seymour H. Block 

		 	Title:	 	Trustee

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	            
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	Booknet LLC
		 	(Name of Entity)
			
		 	By:	 	 /s/ D. Karp 

		 	Name:	 	 D. Karp 

		 	Title:	 	Member
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	 
		 	Name	 	 
		 	Address:	 	 
		 	 

 
			
		
	Email Address:	 	 
		
	Phone Number:	 	 

  

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Richard Brown
		 	Name:	 	Richard Brown
		 	Address:	 	[***]
		 	 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Brandon Jones
		 	Name:	 	Brandon Jones
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
            

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Jeff Kurtz
		 	Name:	 	Jeff Kurtz
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
                     

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Charles J. Magolske
		 	Name:	 	Charles J. Magolske
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
                                         

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Stephen R. Mut
		 	Name:	 	Stephen R. Mut
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	(if entity)
		
		 	STOCKHOLDER:
		
		 	 
		 	(Name of Entity)
			
		 	By:	 	
                   
                         

		 	Name	 	 
		 	Title:	 	 

 
					
	
	(if individual)
		
		 	STOCKHOLDER:
		
		 	/s/ Richard A. Smith
		 	Name:	 	Richard A. Smith
		 	Address:	 	[***]
		 	 

 
			
		
	Email Address:	 	[***]
		
	Phone Number:	 	[***]

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	6 DIMENSIONS CAPITAL, L.P.
		
	By:	 	6 Dimensions Capital GP, LLC, its General Partner
		
	By:	 	 /s/ Wei Li

	Name:	 	Wei Li
	Title:	 	Director
	
	6 DIMENSIONS AFFILIATES FUND, L.P.
		
	By:	 	6 Dimensions Capital GP, LLC, its General Partner
		
	By:	 	 /s/ Wei Li

	Name:	 	Wei Li
	Title:	 	Director

 ADOPTION AGREEMENT 

This Adoption Agreement (“Adoption Agreement”), effective as of May 15, 2018, is entered into by the undersigned (the
“Holder”) pursuant to the terms of that certain Third Amended and Restated Stockholders Agreement dated as of December 18, 2017 (the “Agreement”), by and among the Company and certain of its Stockholders, as
such Agreement may be amended or amended and restated hereafter. Capitalized terms used but not defined in this Adoption Agreement shall have the respective meanings ascribed to such terms in the Agreement. By the execution of this Adoption
Agreement, the Holder agrees as follows. 
 1.1 Acknowledgement. Holder acknowledges that Holder is acquiring certain shares of the
capital stock of the Company (the “Stock”), for one of the following reasons (Check the correct box): 
  

	 	☒	 as a transferee of Shares from a party in such party’s capacity as an “Investor” bound by the
Agreement, and after such transfer, Holder shall be considered an “Investor” and a “Stockholder” for all purposes of the Agreement. 

  

	 	☐	 as a transferee of Shares from a party in such party’s capacity as a “Key Holder” bound by the
Agreement, and after such transfer, Holder shall be considered a “Key Holder” and a “Stockholder” for all purposes of the Agreement. 

1.2 Agreement. Holder hereby (a) agrees that the Stock, and any other shares of capital stock or securities required by the
Agreement to be bound thereby, shall be bound by and subject to the terms of the Agreement and (b) adopts the Agreement with the same force and effect as if Holder were originally a party thereto. 

1.3 Notice. Any notice required or permitted by the Agreement shall be given to Holder at the address, email address or facsimile number
listed below Holder’s signature hereto. 
  

									
	HOLDER:	 		 	ACCEPTED AND AGREED:
			
	SHEPHERD 98, LLC	 		 	CENTREXION THERAPEUTICS
					
	By:	 	 /s/ Ron Ellen
	 		 	By:	 	 /s/ Gregg Beloff

	Name:	 	Ron Ellen	 		 	Name:	 	Gregg Beloff
	Title:	 	Manager	 		 	Title:	 	Chief Financial Officer
				
	Address: [***]	 		 		 	
				
	Email: [***]	 		 		 	
				
	Facsimile Number:
                                         
           	 		 		 	

 ADOPTION AGREEMENT 

This Adoption Agreement (“Adoption Agreement”), effective as of June 14, 2018, is entered into by the undersigned (the
“Holder”) pursuant to the terms of that certain Third Amended and Restated Stockholders Agreement dated as of December 18, 2017 (the “Agreement”), by and among the Company and certain of its Stockholders, as
such Agreement may be amended or amended and restated hereafter. Capitalized terms used but not defined in this Adoption Agreement shall have the respective meanings ascribed to such terms in the Agreement. By the execution of this Adoption
Agreement, the Holder agrees as follows. 
 1.1 Acknowledgement. Holder acknowledges that Holder is acquiring certain shares of the
capital stock of the Company (the “Stock”), for one of the following reasons (Check the correct box): 
  

	 	☒	 as a transferee of Shares from a party in such party’s capacity as an “Investor” bound by the
Agreement, and after such transfer, Holder shall be considered an “Investor” and a “Stockholder” for all purposes of the Agreement. 

  

	 	☐	 as a transferee of Shares from a party in such party’s capacity as a “Key Holder” bound by the
Agreement, and after such transfer, Holder shall be considered a “Key Holder” and a “Stockholder” for all purposes of the Agreement. 

1.2 Agreement. Holder hereby (a) agrees that the Stock, and any other shares of capital stock or securities required by the
Agreement to be bound thereby, shall be bound by and subject to the terms of the Agreement and (b) adopts the Agreement with the same force and effect as if Holder were originally a party thereto. 

1.3 Notice. Any notice required or permitted by the Agreement shall be given to Holder at the address, email address or facsimile number
listed below Holder’s signature hereto. 
  

									
	HOLDER:	 		 	ACCEPTED AND AGREED:
			
	ARROWMARK LIFE SCIENCE FUND, LP	 		 	CENTREXION THERAPEUTICS
				
	By:	 	its General Partner ArrowMark Partners GP, LLC	 		 	
					
	By:	 	 /s/ David Corkins
	 		 	By:	 	 /s/ Gregg Beloff

	Name:	 	David Corkins	 		 	Name:	 	Gregg Beloff
	Title:	 	Managing Member	 		 	Title:	 	Chief Financial Officer
				
	Address: [***]	 		 		 	
				
	Phone:	 		 		 	
				
	Email:	 		 		 	

 ADOPTION AGREEMENT 

This Adoption Agreement (“Adoption Agreement”), dated July     , 2018 and effective as of March 28,
2018, is entered into by the undersigned (the “Holder”) pursuant to the terms of that certain Third Amended and Restated Stockholders Agreement dated as of December 18, 2017 (the “Agreement”), by and among the
Company and certain of its Stockholders, as such Agreement may be amended or amended and restated hereafter. Capitalized terms used but not defined in this Adoption Agreement shall have the respective meanings ascribed to such terms in the
Agreement. By the execution of this Adoption Agreement, the Holder agrees as follows. 
 1.1 Acknowledgement. Holder acknowledges that
Holder is acquiring certain shares of the capital stock of the Company (the “Stock”), for one of the following reasons (Check the correct box): 
  

	 	☒	 as a transferee of Shares from a party in such party’s capacity as an “Investor” bound by the
Agreement, and after such transfer, Holder shall be considered an “Investor” and a “Stockholder” for all purposes of the Agreement. 

  

	 	☐	 as a transferee of Shares from a party in such party’s capacity as a “Key Holder” bound by the
Agreement, and after such transfer, Holder shall be considered a “Key Holder” and a “Stockholder” for all purposes of the Agreement. 

1.2 Agreement. Holder hereby (a) agrees that the Stock, and any other shares of capital stock or securities required by the
Agreement to be bound thereby, shall be bound by and subject to the terms of the Agreement and (b) adopts the Agreement with the same force and effect as if Holder were originally a party thereto. 

1.3 Notice. Any notice required or permitted by the Agreement shall be given to Holder at the address, email address or facsimile number
listed below Holder’s signature hereto. 
  

									
	HOLDER:	  		  	ACCEPTED AND AGREED:
			
		  		  	CENTREXION THERAPEUTICS
				
	 /s/ Denice M. Dan
	  		  	By:	  	 /s/ B. N. Harvey

	Denice M. Dan	  		  		  	B. N. Harvey, CFO

									
				
	Address: [***]	  		  		  	
				
	Email Address: [***]	  		  		  	
				
	Facsimile Number:                                
                             	  		  		  	

 ADOPTION AGREEMENT 

This Adoption Agreement (“Adoption Agreement”), dated February     , 2018 and effective as of
March 28, 2018, is entered into by the undersigned (the “Holder”) pursuant to the terms of that certain Third Amended and Restated Stockholders Agreement dated as of December 18, 2017 (the “Agreement”), by
and among the Company and certain of its Stockholders, as such Agreement may be amended or amended and restated hereafter. Capitalized terms used but not defined in this Adoption Agreement shall have the respective meanings ascribed to such terms in
the Agreement. By the execution of this Adoption Agreement, the Holder agrees as follows. 
 1.1 Acknowledgement. Holder acknowledges
that Holder is acquiring certain shares of the capital stock of the Company (the “Stock”), for one of the following reasons (Check the correct box): 
  

	 	☒	 as a transferee of Shares from a party in such party’s capacity as an “Investor” bound by the
Agreement, and after such transfer, Holder shall be considered an “Investor” and a “Stockholder” for all purposes of the Agreement. 

  

	 	☐	 as a transferee of Shares from a party in such party’s capacity as a “Key Holder” bound by the
Agreement, and after such transfer, Holder shall be considered a “Key Holder” and a “Stockholder” for all purposes of the Agreement. 

1.2 Agreement. Holder hereby (a) agrees that the Stock, and any other shares of capital stock or securities required by the
Agreement to be bound thereby, shall be bound by and subject to the terms of the Agreement and (b) adopts the Agreement with the same force and effect as if Holder were originally a party thereto. 

1.3 Notice. Any notice required or permitted by the Agreement shall be given to Holder at the address, email address or facsimile number
listed below Holder’s signature hereto. 
  

									
	HOLDER:	 		 	ACCEPTED AND AGREED:
			
	POZEN FAMILY 2016 TRUST	 		 	CENTREXION THERAPEUTICS
				
	 /s/ David Pozen
	 		 	By:	 	 /s/ Gregg Beloff

	David Pozen and Joanna Pozen, Trustees	 		 	Name:	 	Gregg Beloff
		 		 		 	Title:	 	Chief Financial Officer

									
				
	Address: [***]	 		 		 	
				
	Email Address: [***]	 		 		 	
				
	Facsimile
Number:                                        
                        	 		 		 	

 Schedule I 

Isaac Blech 
 75 Rockefeller Plaza 

29th Floor 
 New York, NY 10019 

Sol J. Barer 
 2 Barer Lane 

Mendham, NJ 07945 
 Jeffrey B. Kindler 

29 Surf Road 
 Westport, CT 06880EX-4.3

 Exhibit 4.3 

Schedule of Holders 
 of 

Warrants to Purchase Common Stock 
  

																	
	 Holder
	  	Number of
Shares	 	  	Exercise Price	 	  	Issuance Date	 	  	Expiration Date	 
	 Silicon Valley Bank
	  	 	76,107	 	  	$	0.484	 	  	 	April 22, 2015	 	  	 	April 21, 2022	 
	 Life Science Loans, LLC
	  	 	76,107	 	  	$	0.484	 	  	 	April 22, 2015	 	  	 	April 21, 2022	 
	 Silicon Valley Bank
	  	 	367,316	 	  	$	1.29	 	  	 	June 27, 2018	 	  	 	June 26, 2028	 

 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS
OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION. 

WARRANT TO PURCHASE STOCK 

Company: Centrexion Therapeutics Corporation, a Delaware corporation 

Number of Shares: _______ , subject to adjustment 

Type/Series of Stock: Common Stock, $0.001 par value per share 

Warrant Price: $___ per Share, subject to adjustment 

Issue Date: ____________ 
 Expiration Date:
__________        See also Section 5.1(b). 

	Credit	 Facility: This Warrant to Purchase Stock (“Warrant”) is issued in connection
with that certain Second Amendment, of even date herewith, to that certain Loan and Security Agreement dated April 22, 2015, among ____________, the Company, Centrexion I, Inc. and Centrexion II, LLC, as amended (collectively, and as may be
further amended and/or modified and in effect from time to time, the “Loan Agreement”). 

 THIS
WARRANT CERTIFIES THAT, for good and valuable consideration, __________ (together with any successor or permitted assignee or transferee of this Warrant or of any shares issued upon exercise hereof, “Holder”) is entitled to
purchase the number of fully paid and non-assessable shares (the “Shares”) of the above-stated Type/Series of Stock (the “Class”) of the above-named company (the
“Company”) at the above-stated Warrant Price, all as set forth above and as adjusted pursuant to Section 2 of this Warrant, subject to the provisions and upon the terms and conditions set forth in this Warrant. Reference
is made to Section 5.4 of this Warrant whereby _________ shall transfer this Warrant to its parent company, ______________. 
 SECTION
1. EXERCISE. 
 1.1 Method of Exercise. Holder may at any time and from time to time exercise this Warrant, in whole or in
part, by delivering to the Company the original of this Warrant together with a duly executed Notice of Exercise in substantially the form attached hereto as Appendix 1 and, unless Holder is exercising this Warrant pursuant to a cashless exercise
set forth in Section 1.2, a check, wire transfer of same-day funds (to an account designated by the Company), or other form of payment acceptable to the Company for the aggregate Warrant Price for the
Shares being purchased. 
 1.2 Cashless Exercise. On any exercise of this Warrant, in lieu of payment of the aggregate Warrant Price
in the manner as specified in Section 1.1 above, but otherwise in accordance with the requirements of Section 1.1, Holder may elect to receive Shares equal to the value of this Warrant, or portion hereof as to which this Warrant is being
exercised. Thereupon, the Company shall issue to the Holder such number of fully paid and non-assessable Shares as are computed using the following formula: 

X = Y(A-B)/A 

where: 

  
 2 

	 	X =	 the number of Shares to be issued to the Holder; 

 

	 	Y =	 the number of Shares with respect to which this Warrant is being exercised (inclusive of the Shares surrendered
to the Company in payment of the aggregate Warrant Price); 

  

	 	A =	 the Fair Market Value (as determined pursuant to Section 1.3 below) of one Share; and

  

	 	B =	 the Warrant Price. 

1.3 Fair Market Value. If shares of the Class are then traded or quoted on a nationally recognized securities exchange,
inter-dealer quotation system or over-the-counter market (a “Trading Market”), the fair market value of a Share shall be the closing price or
last sale price of a share of the Class reported for the Business Day immediately before the date on which Holder delivers this Warrant together with its Notice of Exercise to the Company. If shares of the Class are not then traded in a
Trading Market, the Board of Directors of the Company shall determine the fair market value of a Share in its reasonable good faith judgment. 

1.4 Delivery of Certificate and New Warrant. Within a reasonable time after Holder exercises this Warrant in the manner set forth in
Section 1.1 or 1.2 above, the Company shall deliver to Holder a certificate representing the Shares issued to Holder upon such exercise and, if this Warrant has not been fully exercised and has not expired, a new warrant of like tenor
representing the Shares not so acquired. 
 1.5 Replacement of Warrant. On receipt of evidence reasonably satisfactory to the Company
of the loss, theft, destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form, substance and amount to the Company or, in the case of mutilation,
on surrender of this Warrant to the Company for cancellation, the Company shall, within a reasonable time, execute and deliver to Holder, in lieu of this Warrant, a new warrant of like tenor and amount. 

1.6 Treatment of Warrant Upon Acquisition of Company. 

(a) Acquisition. For the purpose of this Warrant, “Acquisition” means any transaction or series of related
transactions involving: (i) the sale, lease, exclusive license, or other disposition of all or substantially all of the assets of the Company (ii) any merger or consolidation of the Company into or with another person or entity (other than
a merger or consolidation effected exclusively to change the Company’s domicile), or any other corporate reorganization, in which the stockholders of the Company in their capacity as such immediately prior to such merger, consolidation or
reorganization, own less than a majority of the Company’s (or the surviving or successor entity’s) outstanding voting power immediately after such merger, consolidation or reorganization (or, if such Company stockholders beneficially own a
majority of the outstanding voting power of the surviving or successor entity as of immediately after such merger, consolidation or reorganization, such surviving or successor entity is not the Company); or (iii) any sale or other transfer by
the stockholders of the Company of shares representing at least a majority of the Company’s then-total outstanding combined voting power. 

  
 3 

 (b) Treatment of Warrant at Acquisition. In the event of an Acquisition in which the
consideration to be received by the Company’s stockholders consists solely of cash, solely of Marketable Securities or a combination of cash and Marketable Securities (a “Cash/Public Acquisition”), and the fair market
value of one Share as determined in accordance with Section 1.3 above would be greater than the Warrant Price in effect on such date immediately prior to such Cash/Public Acquisition, and Holder has not exercised this Warrant pursuant to
Section 1.1 above as to all Shares, then this Warrant shall automatically be deemed to be Cashless Exercised pursuant to Section 1.2 above as to all Shares effective immediately prior to and contingent upon the consummation of a
Cash/Public Acquisition. In connection with such Cashless Exercise, Holder shall be deemed to have restated each of the representations and warranties in Section 4 of the Warrant as of the date thereof and the Company shall promptly notify the
Holder of the number of Shares (or such other securities) issued upon exercise. In the event of a Cash/Public Acquisition where the fair market value of one Share as determined in accordance with Section 1.3 above would be less than the Warrant
Price in effect immediately prior to such Cash/Public Acquisition, then this Warrant will expire immediately prior to the consummation of such Cash/Public Acquisition. 

(c) Upon the closing of any Acquisition other than a Cash/Public Acquisition, the acquiring, surviving or successor entity shall assume the
obligations of this Warrant, and this Warrant shall thereafter be exercisable for the same securities and/or other property as would have been paid for the Shares issuable upon exercise of the unexercised portion of this Warrant as if such Shares
were outstanding on and as of the closing of such Acquisition, subject to further adjustment from time to time in accordance with the provisions of this Warrant. 

(d) As used in this Warrant, “Marketable Securities” means securities meeting all of the following requirements:
(i) the issuer thereof is then subject to the reporting requirements of Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and is then current in its filing of
all required reports and other information under the Act and the Exchange Act; (ii) the class and series of shares or other security of the issuer that would be received by Holder in connection with the Acquisition were Holder to exercise this
Warrant on or prior to the closing thereof is then traded in a Trading Market, and (iii) following the closing of such Acquisition, Holder would not be restricted from publicly re-selling all of the
issuer’s shares and/or other securities that would be received by Holder in such Acquisition were Holder to exercise this Warrant in full on or prior to the closing of such Acquisition, except to the extent that any such restriction
(x) arises solely under federal or state securities laws, rules or regulations, and (y) does not extend beyond six (6) months from the closing of such Acquisition. 

SECTION 2. ADJUSTMENTS TO THE SHARES AND WARRANT PRICE. 

2.1 Stock Dividends, Splits, Etc. If the Company declares or pays a dividend or distribution on the outstanding shares of the
Class payable in additional shares of the Class or other securities or property (other than cash), then upon exercise of this Warrant, for each Share acquired, Holder shall receive, without additional cost to Holder, the total number and
kind of securities and property which Holder would have received had Holder owned the Shares of record as of the date the dividend or distribution occurred. If the Company subdivides the outstanding shares of the Class by reclassification or
otherwise into a greater number of shares, the number of Shares purchasable hereunder shall be proportionately increased and the Warrant Price shall be proportionately decreased. If the outstanding shares of the Class are combined or
consolidated, by reclassification or otherwise, into a lesser number of shares, the Warrant Price shall be proportionately increased and the number of Shares shall be proportionately decreased. 

  
 4 

 2.2 Reclassification, Exchange, Combinations or Substitution. Upon any event whereby
all of the outstanding shares of the Class are reclassified, exchanged, combined, substituted, or replaced for, into, with or by Company securities of a different class and/or series, then from and after the consummation of such event, this
Warrant will be exercisable for the number, class and series of Company securities that Holder would have received had the Shares been outstanding on and as of the consummation of such event, and subject to further adjustment thereafter from time to
time in accordance with the provisions of this Warrant. The provisions of this Section 2.2 shall similarly apply to successive reclassifications, exchanges, combinations, substitutions, replacements or other similar events. 

2.3 No Fractional Share. No fractional Share shall be issuable upon exercise of this Warrant and the number of Shares to be issued
shall be rounded down to the nearest whole Share. If a fractional Share interest arises upon any exercise of the Warrant, the Company shall eliminate such fractional Share interest by paying Holder in cash the amount computed by multiplying the
fractional interest by (i) the fair market value (as determined in accordance with Section 1.3 above) of a full Share, less (ii) the then-effective Warrant Price. 

2.4 Notice/Certificate as to Adjustments. Upon each adjustment of the Warrant Price, Class and/or number of Shares, the Company,
at the Company’s expense, shall notify Holder in writing within a reasonable time setting forth the adjustments to the Warrant Price, Class and/or number of Shares and facts upon which such adjustment is based. The Company shall, upon
written request from Holder, furnish Holder with a certificate of its Chief Financial Officer, including computations of such adjustment and the Warrant Price, Class and number of Shares in effect upon the date of such adjustment. 

SECTION 3. REPRESENTATIONS AND COVENANTS OF THE COMPANY. 

3.1 Representations and Warranties. The Company represents and warrants to, and agrees with, the Holder as follows: 

(a) The initial Warrant Price referenced on the first page of this Warrant is not greater than the fair market value of a share of the
Class as determined by the most recently completed valuation, approved by the Company’s Board of Directors, of the Company’s stock for purposes of its compliance with Section 409A of the Internal Revenue Code of 1986, as amended.

 (b) The number of Shares for which this Warrant is exercisable on and as of the Issue Date hereof represents not less than 0.30% of the
Company’s total issued and outstanding shares of common stock, calculated on a fully-diluted basis assuming (i) the conversion into common stock of all outstanding securities and instruments (including, without limitation, securities
deemed to be outstanding pursuant to clause (ii) of this Section 3.1(b)) convertible by their terms into shares of common stock (regardless of whether such securities or instruments are by their terms now so convertible), and (ii) the
exercise in full of all outstanding options, warrants (including, without limitation, this Warrant) and other rights to purchase or acquire shares of common stock or securities exercisable for or convertible into shares of common stock (regardless
of whether such options, warrants or other rights to purchase or acquire are by their terms now exercisable). 
 (c) All Shares which may
be issued upon the exercise of this Warrant shall, upon issuance, be duly authorized, validly issued, fully paid and non-assessable, and free of any liens and encumbrances except for restrictions on transfer
provided for herein or under applicable federal and state securities laws. The Company covenants that it shall at all times cause to be reserved and kept available out of its authorized and unissued capital stock such number of shares of the
Class and other securities as will be sufficient to permit the exercise in full of this Warrant. 

  
 5 

 (d) The Company’s capitalization table attached hereto as Schedule 1 is true
and complete, in all material respects, as of the Issue Date. 
 3.2 Notice of Certain Events. If the Company proposes at any time
to: 
 (a) declare any dividend or distribution upon the outstanding shares of the Class, whether in cash, property, stock, or other
securities and whether or not a regular cash dividend; 
 (b) offer for subscription or sale pro rata to the holders of the outstanding
shares of the Class any additional shares of any class or series of the Company’s stock (other than pursuant to contractual pre-emptive rights); 

(c) effect any reclassification, exchange, combination, substitution, reorganization or recapitalization of the outstanding shares of the
Class; 
 (d) effect an Acquisition or to liquidate, dissolve or wind up; or 

(e) effect its initial, underwritten offering and sale of its securities to the public pursuant to an effective registration statement under
the Act (the “IPO”); 
 then, in connection with each such event, the Company shall give Holder: 

(1) in the case of the matters referred to in (a) and (b) above, at least seven (7) Business Days prior written
notice of the earlier to occur of the effective date thereof or the date on which a record will be taken for such dividend, distribution, or subscription rights (and specifying the date on which the holders of outstanding shares of the
Class will be entitled thereto) or for determining rights to vote, if any; 
 (2) in the case of the matters referred to
in (c) and (d) above at least seven (7) Business Days prior written notice of the date when the same will take place (and specifying the date on which the holders of outstanding shares of the Class will be entitled to exchange their
shares for the securities or other property deliverable upon the occurrence of such event and such reasonable information as Holder may reasonably require regarding the treatment of this Warrant in connection with such event giving rise to the
notice); and 
 (3) with respect to the IPO, at least seven (7) Business Days prior written notice of the date on which
the Company proposes to file its registration statement in connection therewith. 
 The Company will also provide information requested by
Holder that is reasonably necessary to enable Holder to comply with Holder’s accounting or reporting requirements. 

  
 6 

 SECTION 4. REPRESENTATIONS, WARRANTIES OF THE HOLDER. 

The Holder represents and warrants to the Company as follows: 

4.1 Purchase for Own Account. This Warrant and the Shares to be acquired upon exercise of this Warrant by Holder are being acquired for
investment for Holder’s account, not as a nominee or agent, and not with a view to the public resale or distribution within the meaning of the Act. Holder also represents that it has not been formed for the specific purpose of acquiring this
Warrant or the Shares. 
 4.2 Disclosure of Information. Holder is aware of the Company’s business affairs and financial
condition and has received or has had full access to all the information it considers necessary or appropriate to make an informed investment decision with respect to the acquisition of this Warrant and its underlying securities. Holder further has
had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering of this Warrant and its underlying securities and to obtain additional information (to the extent the Company possessed such
information or could acquire it without unreasonable effort or expense) necessary to verify any information furnished to Holder or to which Holder has access. 

4.3 Investment Experience. Holder understands that the purchase of this Warrant and its underlying securities involves substantial
risk. Holder has experience as an investor in securities of companies in the development stage and acknowledges that Holder can bear the economic risk of such Holder’s investment in this Warrant and its underlying securities and has such
knowledge and experience in financial or business matters that Holder is capable of evaluating the merits and risks of its investment in this Warrant and its underlying securities and/or has a preexisting personal or business relationship with the
Company and certain of its officers, directors or controlling persons of a nature and duration that enables Holder to be aware of the character, business acumen and financial circumstances of such persons. 

4.4 Accredited Investor Status. Holder is an “accredited investor” within the meaning of Regulation D promulgated under the
Act. 
 4.5 The Act. Holder understands that this Warrant and the Shares issuable upon exercise hereof have not been registered under
the Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of the Holder’s investment intent as expressed herein. Holder understands that this Warrant and the Shares issued
upon any exercise hereof must be held indefinitely unless subsequently registered under the Act and qualified under applicable state securities laws, or unless exemption from such registration and qualification are otherwise available. Holder is
aware of the provisions of Rule 144 promulgated under the Act. 
 4.6 No Voting Rights. Holder, as a Holder of this Warrant, will not
have any voting rights until the exercise of this Warrant. 
 SECTION 5. MISCELLANEOUS. 

5.1 Term; Automatic Cashless Exercise Upon Expiration. 

(a) Term. Subject to the provisions of Section 1.6 above, this Warrant is exercisable in whole or in part at any time and from time
to time on or before 6:00 PM, Pacific time, on the Expiration Date and shall be void thereafter. 
 (b) Automatic Cashless Exercise upon
Expiration. In the event that, upon the Expiration Date, the fair market value of one Share as determined in accordance with Section 1.3 above is greater than the Warrant Price in effect on such date, then this Warrant shall automatically be
deemed on and as of such date to be exercised pursuant to Section 1.2 above as to all Shares for which it shall not previously have been exercised, and the Company shall, within a reasonable time, deliver a certificate representing the Shares issued
upon such exercise to Holder. 

  
 7 

 5.2 Legends. Each certificate evidencing Shares shall be imprinted with a legend in
substantially the following form: 
 THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN THAT CERTAIN WARRANT TO PURCHASE STOCK ISSUED BY THE ISSUER TO _____________ DATED _____, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE
TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION. 

5.3 Compliance with Securities Laws on Transfer. This Warrant and the Shares issued upon exercise of this Warrant may not be
transferred or assigned in whole or in part except in compliance with applicable federal and state securities laws by the transferor and the transferee (including, without limitation, the delivery of investment representation letters and legal
opinions reasonably satisfactory to the Company, as reasonably requested by the Company). The Company shall not require Holder to provide an opinion of counsel if the transfer is to ____________________ or any other affiliate of Holder, provided
that any such transferee is an “accredited investor” as defined in Regulation D promulgated under the Act. Additionally, the Company shall also not require an opinion of counsel if there is no material question as to the availability of
Rule 144 promulgated under the Act. 
 5.4 Transfer Procedure. After receipt by __________ of the executed Warrant, ____________ will
transfer all of this Warrant to its parent company, SVB Financial Group. By its acceptance of this Warrant, ______________ hereby makes to the Company each of the representations and warranties set forth in Section 4 hereof and agrees to be
bound by all of the terms and conditions of this Warrant as if the original Holder hereof. Subject to the provisions of Section 5.3 and upon providing the Company with written notice, __________ and any subsequent Holder may transfer all or
part of this Warrant or the Shares issued upon exercise of this Warrant to any transferee, provided, however, in connection with any such transfer, ________________ or any subsequent Holder will give the Company notice of the portion of the Warrant
and/or Shares being transferred with the name, address and taxpayer identification number of the transferee and Holder will surrender this Warrant to the Company for reissuance to the transferee(s) (and Holder if applicable); and provided further,
that any subsequent transferee other than __________ shall agree in writing with the Company to be bound by all of the terms and conditions of this Warrant. Notwithstanding any contrary provision herein, at all times prior to the IPO, Holder may
not, without the Company’s prior written consent, transfer this Warrant or any portion hereof, or any Shares issued upon any exercise hereof, to any person or entity who directly competes with the Company, except in connection with an
Acquisition of the Company by such a direct competitor. 
 5.5 Notices. All notices and other communications hereunder from the
Company to the Holder, or vice versa, shall be deemed delivered and effective (i) when given personally, (ii) on the third (3rd) Business Day after being mailed by first-class registered
or certified mail, postage prepaid, (iii) upon actual receipt if given by facsimile or electronic mail and such receipt is confirmed in writing by the 

  
 8 

 
recipient, or (iv) on the first Business Day following delivery to a reliable overnight courier service, courier fee prepaid, in any case at such address as may have been furnished to the
Company or Holder, as the case may be, in writing by the Company or such Holder from time to time in accordance with the provisions of this Section 5.5. All notices to Holder shall be addressed as follows until the Company receives notice of a
change of address in connection with a transfer or otherwise: 
  

							
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	

 Notice to the Company shall be addressed as follows until Holder receives notice of a change in address: 

 

							
		 	Centrexion Therapeutics Corporation	  		  	
		 	Attn: Chief Financial Officer	  		  	
		 	200 State Street, 6th Floor	  		  	
		 	Boston, MA 02109	  		  	
		 	Telephone: (617) 837-6911	  		  	
		 	Email: gbeloff@centrexion.com	  		  	
			
		 	With a copy (which shall not constitute notice) to:	  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	
		 	  
	  		  	

 5.6 Waiver. This Warrant and any term hereof may be changed, waived, discharged or terminated (either
generally or in a particular instance and either retroactively or prospectively) only by an instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. 

5.7 Attorneys’ Fees. In the event of any dispute between the parties concerning the terms and provisions of this
Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorneys’ fees. 

5.8 Counterparts; Facsimile/Electronic Signatures. This Warrant may be executed in counterparts, all of which together shall constitute
one and the same agreement. Any signature page delivered electronically or by facsimile shall be binding to the same extent as an original signature page with regards to any agreement subject to the terms hereof or any amendment thereto. 

  
 9 

 5.9 Governing Law. This Warrant shall be governed by and construed in accordance with
the laws of the State of Delaware, without giving effect to its principles regarding conflicts of law. 
 5.10 Headings. The headings
in this Warrant are for purposes of reference only and shall not limit or otherwise affect the meaning of any provision of this Warrant. 

5.11 Business Days. “Business Day” is any day that is not a Saturday, Sunday or a day on which ____________ is
closed. 
 [Remainder of page left blank intentionally] 

[Signature page follows] 

  
 10 

 IN WITNESS WHEREOF, the parties have caused this Warrant to Purchase Stock to be executed by
their duly authorized representatives effective as of the Issue Date written above. 
  

			
	“COMPANY”
	
	CENTREXION THERAPEUTICS CORPORATION
		
	By:	 	 
		
	Name:	 	 
		 	(Print)
	Title:	 	

  

			
	“HOLDER”
		
	By:	 	 
		
	Name:	 	 
		 	(Print)
	Title:	 	

  
 11 

 APPENDIX 1 

NOTICE OF EXERCISE 
 1.
The undersigned Holder hereby exercises its right to purchase ___________ shares of the Common/Series ______ Preferred [circle one] Stock of __________________ (the “Company”) in accordance with the attached Warrant To
Purchase Stock, and tenders payment of the aggregate Warrant Price for such shares as follows: 
 [     ] check in the
amount of $________ payable to order of the Company enclosed herewith 
 [     ] Wire transfer of immediately available
funds to the Company’s account 
 [     ] Cashless Exercise pursuant to Section 1.2 of the Warrant 

[     ] Other [Describe] __________________________________________ 

2. Please issue a certificate or certificates representing the Shares in the name specified below: 

 

	
	
            Holder’s Name

 

	
	 
	             (Address)

 3. By its execution below and for the benefit of the Company, Holder hereby restates each of the
representations and warranties in Section 4 of the Warrant to Purchase Stock as of the date hereof. 
  

			
	HOLDER:
	
	 
		
	By:	 	 
		
	Name:	 	 
		
	Title:	 	 
		
	(Date):	 	 

 Appendix 1 

 SCHEDULE 1 

Company Capitalization Table 

See attached 
 Schedule 1

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