Document:

<PAGE>
                                                                   EXHIBIT 10.41

                              NOTICE OF GRANT AWARD

 SMALL BUSINESS INNOVATION RESEARCH PROG                  Issue Date: 03/25/2002
 Department of Health and Human Services
 National Institutes Of Health
 NATIONAL EYE INSTITUTE
 Grant Number:           1 R43 EY13346-OlAl
 Principal investigator: SWANSON, JOHN W BA, BS
 Project Title:          Aqueous Vein Drain Tube

 SASS, DICK
 PRESIDENT
 MICROHELIX, INC
 16125 SW 72ND AVE
 PORTLAND, OR 97224
 UNITED STATES

 Budget Period:  04/01/2002 - 09/30/2002
 Project Period: 04/01/2002 - 09/30/2002

 Dear Business Official:

 The National Institutes of Health hereby awards a grant in the amount of
 $105,007(see "Award Calculation" in Section 1) to MICROHELIX, INC. in support
 of the above referenced project. This award is pursuant to the authority of 42
 USC 241 42 CFR PART 52 15 USC 638 and is subject to terms and conditions
 referenced below.

 Acceptance of this award including the Terms and Conditions is acknowledged by
 the grantee when funds are drawn down or otherwise obtained from the grant
 payment system.

 Award recipients are responsible for reporting inventions derived or reduced to
 practice in the performance of work under this grant. Rights to inventions vest
 with the grantee organization provided certain requirements are met and there
 is acknowledgement of NIH support. In addition, recipients must ensure that
 patent and license activities are consistent with their responsibility io make
 unique research resources developed under this award available to the
 scientific community, in accordance with NIH policy. For additional
 information, please visit http://www.iedison.gov.

 If you have any questions about this award, please contact the individual(s)
 referenced in the information below.

 Sincerely yours,

 William W Darby
 Grants Management Officer
 NATIONAL EYE INSTITUTE

 See additional information below
<PAGE>
 SECTION I - AWARD DATA - I R43 EY13346-OlAl

 AWARD CALCULATION (U.S. Dollars):

<TABLE>
<S>                                                                     <C>
 Salaries and wages                                                     $ 16,075
 Fringe Benefits                                                        $  5,144
 Personnel Costs                                                        $ 21,219
 Equipment                                                              $  5,056
 Supplies                                                               $  7,081
 Travel Costs                                                           $     95
 other Costs                                                            $  4,900
 Consortium/Contractual Cost                                            $ 33,000
 Federal Direct Costs                                                   $ 71,351
 Federal F&A Costs,                                                     $ 26,786
 APPROVED BUDGET                                                        $ 98,137
 Fee                                                                    $  6,870
 TOTAL FEDERAL AWARD AMOUNT                                             $105,007
</TABLE>

  FISCAL INFORMATION:
  CFDA Number:    93.867
  EIN:  191175862IA1
  Document Number:     R3EY13346A

  IC/   CAN            FY2002
  EY/8426617           105,007

  NIH ADMINISTRATIVE DATA:
  PCC: 4C /ESL / OC: 41.4A /Processed: WDARBY 020322 0114

  SECTION II - PAYMENT/HOTLINE INFORMATION - 1 R43 EY13346-OIAI

  For Payment and HHS Office of Inspector General Hotline Information, see the
  NIH Home Page at http://grants.nih.gov/grants/policy/awardconditions.htm

  SECTION III - TERMS AND CONDITIONS - 1 R43 EY13346-01AI

 This award is based on the application submitted to, and as approved by, the
 NIH on the above-titled project and is subject to the terms and conditions
 incorporated either directly or by reference in the following:

 a. The grant program legislation and program regulation cited in this Notice of
 Grant Award.

 b. The restrictions on the expenditure of federal funds in appropriations
  acts, to the extent those restrictions are pertinent to the award.

 c. 45 CFR Part 74 or 45 CFR Part 92 as applicable.

 d. The NIH Grants Policy Statement, including addenda in effect as of the
 beginning date of the budget period.

 e. This award notice, INCLUDING THE TERMS AND CONDITIONS CITED BELOW.

 (see NIH Home Page at http://grants.nih.gov/grants/policy/awardconditions.htm
 for certain references cited above.)

 Carry over of an unobligated balance into the next budget period requires
 Grants Management officer prior approval.

 Treatment of Program Income:
 Additional Costs

 FIXED FEE

 The fixed fee provided as part of this grant award is in addition to allowable
 direct and
<PAGE>
  facilities and administrative costs. An equitable adjustment of the fee will
  be made in the event the grant is terminated. The fee should be drawn down
  from the DHHS Payment Management System in increments based upon the
  percentage of completion of the project.

  The fixed fee provided as part of this grant award is in addition to allowable
  direct and facilities and administrative costs. An adjustment of the fee will
  be made in the event the grant is terminated. The fee is to be drawn down from
  the HHS Payment Management system in increments proportionate to the draw-down
  of funds for costs.

  INTELLECTUAL PROPERTY RIGHTS Normally, the grantee organization retains the
  principal worldwide patent rights to any invention developed with United
  States government support. Under Title 37 Code of Federal Regulations Part
  401, the Government receives a royalty-free license for its use, reserves the
  right to require the patent holder to license others in certain circumstances,
  and requires that anyone exclusively licensed to sell the invention in the
  United States must normally manufacture it substantially in the United States.
  To the extent authorized by Title 35 United States Code Section 205,'the
  Government will not make public any information disclosing a
  Government-supported invention for a 4-year period to allow the grantee
  organization a reasonable time to file a patent application, nor will the
  Government release any information that is part of that application.

  COST PRINCIPLES Allowable costs of activities conducted by for-profit
  organizations will be determined by applying the contract cost principles and
  procedures set forth in part 31 of the Federal Acquisition Regulations (FAR).
  However, independent research and development costs (including the facilities
  and administrative costs allocable to them) are unallowable.

  AUDIT REQUIREMENTS The Code of Federal Regulations (Title 45 Part 74.26)
  stipulates that commercial (forprofit) organizations are subject to the audit
  requirements contained in OMB Circular A?133. According to that Circular,
  entities that expend $300,000 or more in a year in Federal funds are required
  to have an audit performed for that year.

  PRIOR APPROVAL Prior approval from the awarding office-is required for the
  following actions:

  o Change in scope or objectives of the grant-supported activities. The
  following actions are likely to be considered a change in scope:

     a. Change in the specific aims approved at the time of award

     b. Substitution of one animal model for another.

     c. Any change from the approved use of animals or human subjects.

     d. Shifting the emphasis of the research from one disease area to another.

     e. Applying a new technology, i.e., changing assays from those approved to
  use of a different type of assay.

     f. Change in key personnel whose expertise is critical to the approved
  project.

     g. Significant rebudgeting whether or not it requires approval under rules
  governing budget changes. Significant rebudgeting occurs when the cumulative
  amount of transfers among direct cost categories for the current budget period
  exceeds 25 percent of the total amount awarded, or $250,000, whichever is
  less.

     h. Incurrence of patient care costs not previously' approved by PHS and/or
  when a grantee desires to rebudget funds out of the patient care category

  o  Change in Principal Investigator or other key personnel identified on the
     Notice of Grant Award.

  o  Change of Grantee organization, successor in interest, or recipient
     institution name change.

  o  Deviations from special terms or conditions stated on the Notice of Grant
     Award require prior approval from the PHS awarding Office.

  o  Transferring Substantive Programmatic Work to a third party.

  o  Extensions of the Budget/Project Period With or Without Additional Funds.

  o  Equipment purchases exceeding $25,000 per unit.

  o  Alterations and Renovations exceeding $50,000 in a budget period.

  o  The cost of acquisition or production of audiovisual materials exceeding
     $25,000 for a single audiovisual product.

  o  Patient care costs not previously approved by PHS and/or when a grantee
     desires to rebudget funds out of the patient care category.

  o  Publication and printing costs exceeding $25,000 for a single publication
     when not included in the originally approved budget.

  o  Preaward Costs Incurred More Than 90 Days Prior to the Effective Date of
     any New or
<PAGE>
 Competing Continuation Award.

 o  Actions Requiring Additional Federal Funds.

 Such prior approval should be requested in a letter signed by the Principal
 Investigator and a Business Official of the grantee organization, should be
 addressed to the Grants Management Specialist identified on the Notice of Grant
 Award, and should include an explanation and justification for the action(s) .
 The above is an abbreviated list and does not include all actions which require
 prior approval. If there are any questions as to whether an action requires
 prior approval, contact the Grants Management Specialist listed below.

 ELLEN S LIBERMAN, Program Official
 Phone: (301) 496-5301  Email: esl@nei-nih.gov

 Linda Dingle, Grants Specialist
 Phone: (301) 451-2020  Email: ltd@nei.nih.gov   Fax: (301) 496-9997

 SPREADSHEET
 GRANT NUMBER: 1 R43
 EY13346-01AI
 P.I.: SWANSON, JOHN W
 INSTITUTION: MICROHELIX, INC.

<TABLE>
<CAPTION>
                                  YEAR  01

<S>                                <C>
  Salaries and Wages               16,07S
  Fringe Benefits                   5,144
  Personnel Costs                  21,219
  Equipment                         5,056
  supplies                          7,081
  Travel Costs                         95
  Other Costs                       4,900
  Consortium/Contractual Cost      33,000

  TOTAL FEDERAL DC                 71,351
  TOTAL FEDERAL F&A                26,786
  TOTAL COST                       98,137
</TABLE>

<TABLE>
<CAPTION>
                                YEAR   01

<S>                             <C>
  F&A Cost Rate 1                   32.00%
  F&A Cost Base 1                  16,075
  F&A Costs 1                       5,144
  F&A Cost Rate 2                   65.00%
  F&A Cost Base 2                  33,295
  F&A Costs 2                      21,642

  FEE                               6,870
</TABLE><PAGE>
                                                                   EXHIBIT 10.42

                              NOTICE OF GRANT AWARD

 SMALL BUSINESS INNOVATION RESEARCH PROG                  Issue Date: 09/12/2002
 Department of Health and Human Services
 National Institutes Of Health
 NATIONAL CANCER INSTITUTE

 Grant Number: 1 R43 CA94374-01
 Principal Investigator: SWANSON, JOHN W BA, BS
 Project Title:          High Density 1024 Channel Ultrasound Imaging Connector

 MICROHELEX, INC.
 16125 SW 72ND AVENUE
 PORTLAND, OR 97224
 UNITED STATES

  Budget Period: 09/13/2002 - 02/28/2003
  Project Period: 09/13/2002 - 02/28/2003

  Dear Business official:

  The National Institutes of Health hereby awards a grant in the amount of
  $99,217(see "Award Calculation" in Section I) to MICROHELIX, INC. in support
  of the above referenced project. This award is pursuant to the authority of 42
  USC 241 42 CFR PART 5215 USC 638 and is subject to terms and conditions
  referenced below.

  Acceptance of this award including the Terms and Conditions is acknowledged by
  the grantee when funds are drawn down or otherwise obtained from the grant
  payment system.

  Award recipients are responsible for reporting inventions derived or reduced
  to practice in the performance of work under this grant. Rights to inventions
  vest with the grantee organization provided certain requirements are met and
  there is acknowledgement of NIH support. In addition, recipients must ensure
  that patent and license activities are consistent with their responsibility to
  make unique research resources developed under this award available to the
  scientific community, in accordance with NIH policy. For additional
  information, please visit http://www.iedison.gov.

  If you have any questions about this award, please contact the individual(s)
  referenced in the information below.

  Sincerely yours,

       JANE PAULL

  Grants Management officer
  NATIONAL CANCER INSTITUTE

  See additional information below
<PAGE>
 SECTION I - AWARD DATA - 1 R43 CA94374-01

 AWARD CALCULATION (U.S. Dollars):

<TABLE>
<S>                                                                      <C>
 Salaries and Wages                                                      $25,947
 Fringe Benefits                                                         $ 8,044
 Personnel Costs                                                         $33,991
 Consultant Services                                                     $ 2,927
 Equipment                                                               $10,751
 Supplies                                                                $ 6,766
 Travel Costs                                                            $ 2,848
 Other Costs                                                             $ 4,713
 Federal Direct Costs                                                    $61,996
 Federal F&A Costs                                                       $30,730
 APPROVED BUDGET                                                         $92,726
 Fee                                                                     $ 6,491
 TOTAL FEDERAL AWARD AMOUNT                                              $99,217
</TABLE>

 FISCAL INFORMATION:
 CFDA Number:    93.394
 EIN: 191175862lAl
 Document Number:     R3CA94374A

 IC/  CAN             FY2002
 CA/ 8423311          99,217

 NIH ADMINISTRATIVE DATA:
 PCC: 2YDI   OC: 41.4A /Processed: MILLERL 020829 1040

 SECTION II PAYMENT/HOTLINE INFORMATION 1 R43 CA94374-01

 For Payment and HHS Office of Inspector General Hotline Information, see the
 NIH Home Page at http://grants.nih.gov/grants/policy/awardconditions.htm

 SECTION III - TERMS AND CONDITIONS - 1 R43 CA94374-01

 This award is based on the application submitted to, and as approved by, the
 NIH on the above-titled project and is subject to the terms and conditions
 incorporated either directly or by reference in the following:

 a. The grant program legislation and program regulation cited in this Notice of
 Grant Award.

 b. The restrictions on the expenditure of federal funds in appropriations acts,
 to the extent those restrictions are pertinent to the award.

 c. 45 CFR Part 74 or 45 CFR Part 92 as applicable.

 d. The NIH Grants Policy Statement, including addenda in effect as of the
 beginning date of the budget period.

 e. This award notice, INCLUDING THE TERMS AND CONDITIONS CITED BELOW.

 (see NIH Home Page at http://grants.nih.gov/grants/policy/awardconditions.htm
 for certain references cited above.)

 Carry over of an unobligated balance into the next budget period requires
 Grants Management officer prior approval.

 Treatment of Program Income:
 Additional Costs

 RESTRICTION Although the amount of this award reflects support for estimated
 facilities and administrative costs of $30,730, only 10% of salaries and wages
 ($3,399) will be
<PAGE>
 released to support facilities and administrative costs in the absence of a
 negotiated facilities and administrative cost rate. The remaining funds which
 have been awarded for facilities and administrative costs ($27,331) are
 restricted and may not be used for any purpose until the Financial Advisory
 Services Branch, NIH, notifies the grants management specialist that a
 facilities and administrative cost rate has been negotiated. The NCI will then
 issue a revised award to remove the restriction on the additional allowable
 facilities and administrative costs.

 The grantee should submit a facilities and administrative cost rate proposal to
 the Financial Advisory Services Branch no later than 3 months after the
 effective date of the grant award. If this proposal is not submitted by
 12/13/2002, the restricted funds will not be released for use in the current
 budget period. No funds may be claimed for facilities and administrative costs
 in the current budget period if a timely proposal has not been submitted.

 REQUIREMENT This award is subject to the requirements pertaining to the
 awardee's financial and business management systems, as set forth in the
 document entitled "Requirements for Financial and Business Management Systems
 for SBIR/STTR Awardees," which was enclosed in Mr. Leo F. Buscher Jr.'s letter
 dated 3/11/2002 to the Organization's Business official, and which is hereby
 incorporated by reference.

 Prior to drawing down funds for this award from the payment management system,
 the awardee is required to have in place written policies and procedures for
 financial and business management systems that comply with the standards set
 forth in "Requirements for Financial and Business Management Systems for
 SBTR/STTR Awardees," and must follow those policies and procedures for the
 duration of this project.

 An additional hard copy of the document, "Requirements for Financial and
 Business Management Systems for SBIR/STTR Awardees," can be obtained by
 contacting the grants management specialist identified on the award notice.

 REQUIREMENT In accordance with the Travel Expenses Act of 1985, reimbursement
 for travel expenses charged to this grant may not exceed Federal travel and per
 them limitations. GSA Travel Regulations are available on the Internet at:
 http://policyworks.gov/org/main/mt/homepage/mtt/ftr/ftrhp-shmtl

 REQUIREMENT The grantee is required to establish a positive time and effort
 reporting system to document personnel costs charged to this project as direct
 costs.

 REQUIREMENT A separate project ledger must be established to accumulate and
 monitor the direct costs of this grant-supported project by budget category.

 INFORMATION This award represents the final year of the competitive segment for
 this grant. Therefore, as stated in the NIH Grants Policy Statement, March
 2001, (http://grants.nih.gov/grants/policy/nihgps_2001/) a Financial Status
 Report (OMB 269) (http://www.whitehouse.gov/OMB/grants/sf269a.pdf) must be
 submitted within 90 days of the expiration date. In addition, unless an
 application for competitive renewal is funded, grant closeout documents
 consisting of a Final Invention Statement (HHS 568 available at
 http://grants.nih.gov/grants/forms.htm#inventionstatement), (not applicable to
 training, construction, conference or cancer education grants) and a Final
 Progress Report must also be submitted within 90 days of the expiration date.

 The Final Progress Report may be typed on plain white paper and should include,
 at a minimum, a summary statement of progress toward the achievement of the
 originally stated aims, a list of results (positive or negative) considered
 significant, and a list of publications resulting from the project as well as
 plans for further publications. An original and one copy are required.

 The Final Progress Report and Final Invention Statement should be sent to:

 National Cancer Institute (NCI)
 Records Management Center
 Executive Plaza South
 6120 Executive Boulevard, Room T42, MSC 7107
<PAGE>
 Bethesda, MD 20892-7107 Express Mail/Courier
 Service: Rockville, MD 20852 Phone: 301-496-7753
 FAX: 301-402-3409

 The Financial Status Report should be submitted electronically to the Office of
 Financial Management, NIH. Other Financial Status Report may be mailed to:

 GOVERNMENT ACCOUNTING BRANCH
 OFFICE OF FINANCIAL MANAGEMENT
 NATIONAL INSTITUTES OF HEALTH
 31 CENTER DRIVE, ROOM BlB05A, MSC 2050
 BETHESDA, MD 20892-2050

 INFORMATION Intellectual property rights: Normally the awardee organization
 retains the principal worldwide patent rights to any invention developed with
 United States Government support. Under Title 37 Code of Federal Regulations
 Part 401, the Government receives a royalty-free license for its use, reserves
 the right to require the patent holder to license others in certain
 circumstances, and requires that anyone exclusively licensed to sell the
 invention in the United States must normally manufacture it substantially in
 the United States.

 Rights and obligations related to inventions created or reduced to practice as
 a result of this award are detailed in 35 U.S.C. 205 and 37 CFR Part 401. These
 inventions must be reported to the Extramural Invention Reporting and
 Technology Resources Branch, OPERA, NIH, 6705 Rockledge Drive, MSC 7980,
 Bethesda, MD 20892-7080, (301) 435-1986. For additional information, access the
 NIH link on the Interagency Edison web site (www.iedison.gov) which includes an
 electronic invention reporting system, reference information and the text to 37
 CFR 401.

 To the extent authorized by 35 U.S.C., Section 205, the Government will not
 make public any information disclosing an NIH-supported invention for a 4-year
 period to allow the awardee organization a reasonable time to file a patent
 application, nor will the Government release any information that is part of
 that patent application.

 The fee provided as part of this Notice of Grant Award is in addition to direct
 and facilities and administrative costs. The fee is to be drawn down from the
 DHHS Payment Management System in increments proportionate to the draw down of
 costs.

 Allowable costs conducted by for-profit organizations will be determined by
 apply the cost principles of Contracts with Commercial Organizations set forth
 in 48 CFR, Subpart 31.2.

 INFORMATION Prior approval to implement budgetary and programmatic changes,
 where required by PHS Policy, must be obtained in writing from the Grants
 Management contact shown on this Notice of Grant Award.

 INFORMATION Advances of Federal funds must be maintained in a Federally insured
 and interest bearing account. Questions concerning access to the PHS Payment
 Management System should be directed to the PMS office at (301) 443-1660-.

 INFORMATION This award reflects the budget and the budget period negotiated
 between Lisa Miller of the National Cancer Institute and Cynthia Phillips on
 8/29/2002.

 INFORMATION For administrative and management concerns, contact the Grants
 Management Specialist, Ms. Lisa Miller, at (301) 496-2828 or by email at
 millerli@mail.nih.gov. For programmatic and scientific concerns, contact the
 Program Director, Dr. Keyvan Farahani, at (301) 496-9531.

 INFORMATION In a continuing effort to provide exceptional customer service, the
 NCI Grants Administration Branch has set up a Feedback address on its web site
 (http://www.nci.nih.gov/admin/gab/index.htm). General concerns and issues
 related to NCI grants policies, procedures, and practices can be sent to the
 Customer Liaison using this feature. Specific questions or concerns related to
 this grant should be addressed to the
<PAGE>
 Grants Management Specialist listed in the Terms of Award.

 Keyvan Farahani, Program Official
 Phone: 301-451-8491   Email: farahank@mail.nih.gov

 Lisa Miller, Grants Specialist
 Phone: 301-496-2828   Email: millerli@mail.nih.gov

 SPREADSHEET GRANT NUMBER: 1 R43 CA94374-01
 P.I.: SWANSON, JOHN W
 INSTITUTION: MICROHELIX, INC.

<TABLE>
<CAPTION>
                                  YEAR  01

<S>                                <C>
  Salaries and Wages               25,947
  Fringe Benefits                   8,044
  Personnel Costs                  33,991
  Consultant Services               2,927
  Equipment                        10,751
  Supplies                          6,766
  Travel Costs                      2,848
  Other Costs                       4,713

  TOTAL FEDERAL DC                 61,996
  TOTAL FEDERAL F&A                30,730
  TOTAL COST                       92,726
</TABLE>

<TABLE>
<CAPTION>
                                  YEAR  01

<S>                               <C>
  F&ACost Rate 1                   63.60%
  F&ACost Base 1                   48,318
  F&ACosts 1                       30,730

  FEE                               6,491
</TABLE>

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