Document:

Exhibit 10.12

STOCK OPTION AGREEMENT

NEUROTROPE, INC.

 

THIS AGREEMENT is entered into as of the
23rd day of August, 2013 (the “Date of Grant”)

 

BETWEEN:

 

NEUROTROPE, INC., a company incorporated
pursuant to the laws of the State of Nevada,

 

(the “Company”)

 

AND:[Name of Recipient]

 

(the “Optionee”).

 

WHEREAS:

 

The Board of Directors of the Company (the
“Board”) has approved and adopted the Neurotrope, Inc. 2013 Equity Incentive Plan (the “2013 Plan”), pursuant
to which the Board is authorized to grant to employees and other selected persons stock options to purchase common shares of the
Company (the “Common Stock”);

 

The 2013 Plan provides for the granting
of stock options that either (i) are intended to qualify as “Incentive Stock Options” within the meaning of Section
422 of the Internal Revenue Code of 1986, as amended (the “Code”), or (ii) do not qualify under Section 422 of the
Code (“Non-Qualified Stock Options”); and

 

The Board has authorized the grant to Optionee
of options to purchase a total of _______________________ (_______) shares of Common Stock (the “Options”),
which Options are intended to be (select one):

 

[ ]Incentive Stock Options;

 

[  ]Non-Qualified Stock
Options

 

NOW THEREFORE, the Company agrees to offer
to the Optionee the option to purchase, upon the terms and conditions set forth herein and in the Plan, __________________ (______)
shares of Common Stock. Capitalized terms not otherwise defined herein shall have the meanings ascribed thereto in the 2013
Plan.

 

1.                 
Exercise Price. The exercise price of the options shall be US $_____ per share.

 

2.                 
Limitation on the Number of Shares. If the Options granted hereby are Incentive Stock Options, the number of shares
which may be acquired upon exercise thereof is subject to any limitations set forth in the 2013 Plan.

 

    	 

    	 

    

 

3.                 
 Vesting Schedule. The Options shall vest in accordance with Exhibit A. In the event of a Change in Control,
the vesting schedule shall accelerate and any options not yet vested shall become vested concurrent with the closing of that event.

 

4.                 
Options not Transferable. The Options may not be transferred, assigned, pledged or hypothecated in any manner (whether
by operation of law or otherwise) other than by will, by applicable laws of descent and distribution or, in the case of a Non-Qualified
Stock Option, pursuant to a qualified domestic relations order, and shall not be subject to execution, attachment or similar process;
provided, however, that if the Options represent a Non-Qualified Stock Option, such Option is transferable without payment
of consideration to immediate family members of the Optionee or to trusts or partnerships established exclusively for the benefit
of the Optionee and Optionee’s immediate family members. Upon any attempt to transfer, pledge, hypothecate or otherwise dispose
of any Option or of any right or privilege conferred by the 2013 Plan contrary to the provisions thereof, or upon the sale, levy
or attachment or similar process upon the rights and privileges conferred by the 2013 Plan, such Option shall thereupon terminate
and become null and void.

 

5.                 
Investment Intent. By accepting the Options, the Optionee represents and agrees that none of the shares of Common
Stock purchased upon exercise of the Options will be distributed in violation of applicable federal and state laws and regulations.
In addition, the Company may require, as a condition of exercising the Options, that the Optionee execute an undertaking, in such
a form as the Company shall reasonably specify, that the Stock is being purchased only for investment and without any then-present
intention to sell or distribute such shares.

 

6.                 
Termination of Service and Options. Vested Options shall terminate, to the extent not previously exercised, upon
the occurrence of the first of the following events:

 

		(a)	Expiration. [Five (5)] years from the Date of Grant.

 

		(b)	Termination for Cause. The date of the first discovery by the Company of any reason for
an Optionee’s Termination of Service with the Company or any Subsidiary for cause (as determined in the sole discretion of
the Board, the Committee or the Committee-designated officer, the “2013 Plan Administrator”), and, if an Optionee’s
employment or contractual relationship is suspended pending any investigation by the Company as to whether the Optionee’s
Termination of Service should be for cause, the Optionee’s rights under this Agreement and the 2013 Plan shall likewise be
suspended during the period of any such investigation.

 

		(c)	Termination Due to Death or Total and Permanent Disability. The expiration of one (1) year
from the date of the death of the Optionee or the Termination of Service of an Optionee by reason of Total and Permanent Disability.
If an Optionee’s Termination of Service is caused by death, any Option held by the Optionee shall be exercisable only by
the person or persons to whom such Optionee’s rights under such Option shall pass by the Optionee’s will or by the
laws of descent and distribution.

 

    	2

    	 

    

 

		(d)	Termination for Any Other Reason. The expiration of twelve (12) months from the date of
an Optionee’s Termination of Service with the Company or any Subsidiary for any reason whatsoever other than Termination
of Service for cause, death or Total and Permanent Disability.

 

Each unvested Option granted pursuant hereto
shall terminate immediately upon the Optionee’s Termination of Service with the Company or Subsidiary for any reason whatsoever,
including Total and Permanent Disability unless otherwise provided by the 2013 Plan Administrator.

 

7.                 
Stock. In the case of any stock split, stock dividend or like change in the nature of shares of Stock covered by
this Agreement, the number of shares and exercise price shall be proportionately adjusted as provided in Article 14 of the 2013
Plan.

 

8.                 
Exercise of Option. Options shall be exercisable, in full or in part, at any time after vesting, until termination;
provided, however, that any Optionee who is subject to the reporting and liability provisions of Section 16 of the Securities
Exchange Act of 1934 with respect to the Common Stock shall be precluded from selling or transferring any Common Stock or other
security underlying an Option during the six (6) months immediately following the grant of that Option. If less than all of the
shares included in the vested portion of any Option are purchased, the remainder may be purchased at any subsequent time prior
to the expiration of the Option term. No portion of any Option for less than fifty (50) shares (as adjusted pursuant to Article
14 of the 2013 Plan) may be exercised; provided, that if the vested portion of any Option is less than fifty (50) shares, it may
be exercised with respect to all shares for which it is vested. Only whole shares may be issued pursuant to an Option, and to the
extent that an Option covers less than one (1) share, it is unexercisable.

 

Each exercise of the Option shall be by
means of delivery of a notice of election to exercise (which may be in the form attached hereto as Exhibit B) to the [CEO]
of the Company at its principal executive office, specifying the number of shares of Common Stock to be purchased and accompanied
by payment in cash by certified check or cashier’s check in the amount of the full exercise price for the Common Stock to
be purchased. In addition to payment in cash by certified check or cashier’s check, an Optionee or transferee of an Option
may pay for all or any portion of the aggregate exercise price by complying with one or more of the following alternatives:

 

		(a)	by delivering to the Company shares of Common Stock previously held by such person, duly endorsed
for transfer to the Company, or by the Company withholding shares of Common Stock otherwise deliverable pursuant to exercise of
the Option, which shares of Common Stock received or withheld shall have a fair market value at the date of exercise (as determined
by the 2013 Plan Administrator) equal to the aggregate purchase price to be paid by the Optionee upon such exercise;

 

    	3

    	 

    

 

Solely for the purposes of this
paragraph, “fair market value” per share of Common Stock shall mean (A) the average of the closing sales prices, as
quoted on the primary national or regional stock exchange on which the Common Stock is listed, or, if not listed, the OTC Markets
if quoted thereon, on the twenty (20) trading days immediately preceding the date on which the notice of election to exercise is
deemed to have been sent to the Company, or (B) if the Common Stock is not publicly traded as set forth above, as reasonably and
in good faith determined by the Board of Directors of the Company as of the date which the notice of election to exercise is deemed
to have been sent to the Company.

 

For purposes of Rule 144 promulgated
under the Securities Act, it is intended, understood and acknowledged that the shares of Common Stock issued in a cashless exercise
transaction shall be deemed to have been acquired by the Optionee, and the holding period for such shares shall be deemed to have
commenced, on the date the Options were originally issued; or

 

		(b)	by complying with any other payment mechanism approved by the 2013 Plan Administrator at the time
of exercise.

 

It is a condition precedent to the issuance
of shares of Common Stock that the Optionee execute and/or deliver to the Company all documents and withholding taxes required
in accordance with Section 15 of the 2013 Plan.

 

9.                 
Holding period for Incentive Stock Options. In order to obtain the tax treatment provided for Incentive Stock Options
by Section 422 of the Code, the shares of Common Stock received upon exercising any Incentive Stock Options received pursuant to
this Agreement must be sold, if at all, after a date which is later of two (2) years from the date this agreement is entered into
or one (1) year from the date upon which the Options are exercised. The Optionee agrees to report sales of shares prior to the
above determined date to the Company within one (1) business day after such sale is concluded. The Optionee also agrees to pay
to the Company, within five (5) business days after such sale is concluded, the amount necessary for the Company to satisfy its
withholding requirement required by the Code in the manner specified in Section 15 of the 2013 Plan. Nothing in this Section 9
is intended as a representation that Common Stock may be sold without registration under state and federal securities laws or an
exemption therefrom or that such registration or exemption will be available at any specified time.

 

10.             
Resale restrictions may apply. Any resale of the shares of Common Stock received upon exercising any Options will
be subject to resale restrictions contained in the securities legislation applicable to the Optionee. The Optionee acknowledges
and agrees that the Optionee is solely responsible (and the Company is not in any way responsible) for compliance with applicable
resale restrictions.

 

11.             
Subject to 2013 Plan. The terms of the Options are subject to the provisions of the 2013 Plan, as the same may from
time to time be amended, and any inconsistencies between this Agreement and the 2013 Plan, as the same may be from time to time
amended, shall be governed by the provisions of the 2013 Plan, a copy of which has been delivered to the Optionee, and which is
available for inspection at the principal offices of the Company.

 

    	4

    	 

    

 

12.             
Professional Advice. The acceptance of the Options and the sale of Common Stock issued pursuant to the exercise of
Options may have consequences under federal and state tax and securities laws which may vary depending upon the individual circumstances
of the Optionee. Accordingly, the Optionee acknowledges that he or she has been advised to consult his or her personal legal and
tax advisor in connection with this Agreement and his or her dealings with respect to Options. Without limiting other matters to
be considered with the assistance of the Optionee’s professional advisors, the Optionee should consider: (a) the implications
of alternative minimum tax pursuant to the Code; (b) the merits and risks of an investment in the underlying shares of Common Stock;
and (c) any resale restrictions that might apply under applicable securities laws.

 

13.             
No Employment Commitment. The grant of the Options shall in no way constitute any form of agreement or understanding
binding on the Company or any Subsidiary, express or implied, that the Company or any Subsidiary will employ or contract with the
Optionee, for any length of time, nor shall it interfere in any way with the Company’s or, where applicable, a Subsidiary’s
right to terminate Optionee’s employment at any time, which right is hereby reserved.

 

14.             
Entire Agreement. This Agreement is the only agreement between the Optionee and the Company with respect to the Options,
and this Agreement and the 2013 Plan supersede all prior and contemporaneous oral and written statements and representations and
contain the entire agreement between the parties with respect to the Options.

 

15.             
Notices. Any notice required or permitted to be made or given hereunder shall be mailed or delivered personally to
the addresses set forth below, or as changed from time to time by written notice to the other:

 

	The Company:	Neurotrope, Inc.
	 	 	 
	 	 	 
	 	Attention:	 
	 	 
	With a copy to:	Gottbetter & Partners, LLP
	 	488 Madison Avenue, 12th Floor
	 	New York, NY 10022
	 	Attention: Adam S. Gottbetter
	 	 
	The Optionee:	 

 

    	5

    	 

    

 

 

 

NEUROTROPE, INC.

 

Per:                                                                            

James New, CEO

 

 

                                                                                  

[Name of Recipient]

 

____________________________________

Tax ID #

 

    	6

    	 

    

 

EXHIBIT
A

 

TERMS OF THE OPTION

 

	Name of the Optionee:	____________________
	Date of Grant:	_____ __, 201__
	Designation:	[Incentive] [Non-Qualified] Stock Options
	1.Number of Options granted:	___________ shares
	2.Purchase Price:	$______ per share
	3.Vesting Dates:	
         

        _____ __, 201__ – _________ shares

	4.Expiration Date:	_____ __, 201__

 

    	7

    	 

    

 

EXHIBIT
B

To:  Neurotrope, Inc.

 

Attention: [CEO]

Notice of Election to Exercise

 

This Notice of Election to Exercise shall
constitute proper notice under Neurotrope, Inc.’s (the “Company”) 2013 Equity Incentive Plan (the “2013
Plan”) pursuant to Section 8 of that certain Stock Option Agreement (the “Agreement”) dated as of the ___ day
of _______, 201__, between the Company and the undersigned.

 

The undersigned hereby elects to
exercise Optionee’s option to purchase _______ shares of the common stock of the Company at a price of US$____ per
share, for aggregate consideration of US$____, on the terms and conditions set forth in the Agreement and the 2013 Plan. Such
aggregate consideration, in the form specified in Section 8 of the Agreement, accompanies this notice.

 

The Optionee hereby directs the Company
to issue, register and deliver the certificates representing the shares as follows:

 

	Registration Information:	 	Delivery Instructions:
	 	 	 
	Name to appear on certificates	 	Name
	 	 	 
	Address	 	Address
	 	 	 
	 	 	 
	 	 	 
	 	 	Telephone Number

 

DATED at ____________________________________, the day
____ of ________________________, 20___.

                                                                                  

(Name of Optionee – Please type or print)

                                                                                  

(Signature and, if applicable, Office)

                                                                                  

(Address of Optionee)

                                                                                  

(City, State, and Zip Code of Optionee)

 

 

    	8Exhibit 10.13

 

 

 

 

 

TECHNOLOGY
LICENSE AND SERVICES AGREEMENT

 

by and between

 

NEUROTROPE BIOSCIENCE,
INC.,

 

on the one hand,

 

and

 

BLANCHETTE ROCKEFELLER
NEUROSCIENCES INSTITUTE

 

and

 

NRV II, LLC,

 

on the other hand,

 

dated

 

October 31, 2012

 

    	 

    	 

    

 

Technology License and Services
Agreement

 

This Technology License
and Services Agreement is made and entered into as of October 31, 2012 (the “Execution
Date”) by and between Neurotrope BioScience, Inc., a corporation organized and existing under the laws of Delaware
(“Neurotrope”), on the one hand, and Blanchette Rockefeller Neurosciences
Institute, a not-for-profit institution organized and existing under the laws of the State of West Virginia (“BRNI”),
and NRV II, LLC, a limited liability company organized and existing under the laws of the State of Delaware (“NRV
II”), on the other hand. Neurotrope, BRNI and NRV II are sometimes referred to herein, individually, as a “Party”
or, collectively, as the “Parties.”

 

WHEREAS, BRNI
is a 501(c)(3) tax-exempt, not-for-profit, medical research institution dedicated to the study of memory and memory disorders;

 

WHEREAS, NRV
II, an affiliate of NRV I (as defined below), is a limited liability company involved in the facilitation of the advancement of
technology of BRNI;

 

WHEREAS, Neurotrope,
Neuroscience Research Ventures, Inc., a corporation organized and existing under the laws of West Virginia and an affiliate of
BRNI (“NRV I”), Dr. Dan Alkon and certain other Persons are parties
to that certain Stockholders Agreement, dated October 31, 2012 (the “Stockholders Agreement”);

 

WHEREAS, Neurotrope
and each of NRV I, John Abeles, Jim New, and Dr. Dan Alkon are parties to those certain Stock Purchase Agreements, each dated October
31, 2012 (the “Founder Purchase Agreements”);

 

WHEREAS, the
Stockholders Agreement contemplates that Neurotrope and each of the Investor Stockholders (as defined in the Stockholders Agreement)
will become parties to that certain Investor Purchase Agreement (as defined in the Stockholders Agreement) (such Founder Purchase
Agreements and such Investor Purchase Agreement, collectively, the “Purchase Agreements”);

 

WHEREAS, Neurotrope
desires to receive a license from BRNI and a sublicense from NRV II, and BRNI desires to grant a license to Neurotrope and NRV
II desires to grant a sublicense to Neurotrope, in each case with respect to certain technology developed by BRNI; and

 

WHEREAS, Neurotrope
desires to receive certain research and development services from BRNI, and BRNI desires to provide such services to Neurotrope.

 

NOW, THEREFORE,
in consideration of the mutual promises and covenants set forth herein, and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, agree as follows.

 

		1.	Definitions

 

Terms used in this
Agreement with initial capital letters shall have the respective meanings set forth in this Article 1. Terms used in this
Agreement with initial capital letters, but not defined in this Agreement, shall have their respective meanings set forth in the
Stockholders Agreement.

 

    	 

    	 

    

 

		1.1	Action.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “Action”
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           any
                                                                                                                           action,
                                                                                                                           arbitration,
                                                                                                                           audit,
                                                                                                                           claim,
                                                                                                                           demand,
                                                                                                                           hearing,
                                                                                                                           investigation,
                                                                                                                           inquiry,
                                                                                                                           litigation,
                                                                                                                           proceeding
                                                                                                                           or
                                                                                                                           suit
                                                                                                                           (whether
                                                                                                                           civil,
                                                                                                                           criminal,
                                                                                                                           administrative
                                                                                                                           or
                                                                                                                           investigative),
                                                                                                                           including
                                                                                                                           any
                                                                                                                           interference,
                                                                                                                           reissue,
                                                                                                                           re-examination,
                                                                                                                           invalidity,
                                                                                                                           revocation
                                                                                                                           or
                                                                                                                           opposition
                                                                                                                           proceeding,
                                                                                                                           and
                                                                                                                           any
                                                                                                                           solicited
                                                                                                                           or
                                                                                                                           unsolicited
                                                                                                                           offer,
                                                                                                                           demand
                                                                                                                           or
                                                                                                                           request
                                                                                                                           to
                                                                                                                           license
                                                                                                                           any
                                                                                                                           Intellectual
                                                                                                                           Property.

 

		1.2	Affiliate.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “Affiliate”
                                                                                                                           shall
                                                                                                                           mean,
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           any
                                                                                                                           particular
                                                                                                                           Person,
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Person
                                                                                                                           controlling,
                                                                                                                           controlled
                                                                                                                           by,
                                                                                                                           or
                                                                                                                           under
                                                                                                                           common
                                                                                                                           control
                                                                                                                           with,
                                                                                                                           such
                                                                                                                           particular
                                                                                                                           Person,
                                                                                                                           where
                                                                                                                           “control”
                                                                                                                           (together
                                                                                                                           with
                                                                                                                           its
                                                                                                                           correlative
                                                                                                                           terms)
                                                                                                                           means
                                                                                                                           the
                                                                                                                           possession,
                                                                                                                           directly
                                                                                                                           or
                                                                                                                           indirectly,
                                                                                                                           of
                                                                                                                           the
                                                                                                                           power
                                                                                                                           to
                                                                                                                           direct
                                                                                                                           the
                                                                                                                           management
                                                                                                                           and
                                                                                                                           policies
                                                                                                                           of
                                                                                                                           a Person
                                                                                                                           whether
                                                                                                                           through
                                                                                                                           the
                                                                                                                           ownership
                                                                                                                           of
                                                                                                                           voting
                                                                                                                           securities,
                                                                                                                           contract
                                                                                                                           or
                                                                                                                           otherwise,
                                                                                                                           and
                                                                                                                           such
                                                                                                                           “control”
                                                                                                                           will
                                                                                                                           be
                                                                                                                           conclusively
                                                                                                                           presumed
                                                                                                                           if
                                                                                                                           any
                                                                                                                           Person
                                                                                                                           owns
                                                                                                                           ten
                                                                                                                           percent
                                                                                                                           (10%)
                                                                                                                           or
                                                                                                                           more
                                                                                                                           of
                                                                                                                           the
                                                                                                                           voting
                                                                                                                           capital
                                                                                                                           stock
                                                                                                                           or
                                                                                                                           other
                                                                                                                           ownership
                                                                                                                           interests,
                                                                                                                           directly
                                                                                                                           or
                                                                                                                           indirectly,
                                                                                                                           of
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Person.

 

		1.3	Agreement.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “Agreement”
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           this
                                                                                                                           Technology
                                                                                                                           License
                                                                                                                           and
                                                                                                                           Services
                                                                                                                           Agreement,
                                                                                                                           including
                                                                                                                           all
                                                                                                                           SOWs
                                                                                                                           hereunder.

 

		1.4	A
                                                                                                                           Round
                                                                                                                           Financing.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “A
                                                                                                                           Round
                                                                                                                           Financing”
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           the
                                                                                                                           equity
                                                                                                                           financing
                                                                                                                           from
                                                                                                                           the
                                                                                                                           sale
                                                                                                                           of
                                                                                                                           Series
                                                                                                                           A Preferred
                                                                                                                           Stock
                                                                                                                           of
                                                                                                                           Neurotrope,
                                                                                                                           par
                                                                                                                           value
                                                                                                                           $0.01
                                                                                                                           per
                                                                                                                           share
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           the
                                                                                                                           closing
                                                                                                                           of
                                                                                                                           the
                                                                                                                           transactions
                                                                                                                           contemplated
                                                                                                                           by
                                                                                                                           the
                                                                                                                           Founder
                                                                                                                           Purchase
                                                                                                                           Agreements
                                                                                                                           and
                                                                                                                           Investor
                                                                                                                           Purchase
                                                                                                                           Agreements
                                                                                                                           and
                                                                                                                           the
                                                                                                                           actual
                                                                                                                           receipt
                                                                                                                           of
                                                                                                                           the
                                                                                                                           proceeds
                                                                                                                           therefrom
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           (following
                                                                                                                           approval
                                                                                                                           of
                                                                                                                           such
                                                                                                                           receipt
                                                                                                                           by
                                                                                                                           BRNI),
                                                                                                                           it
                                                                                                                           being
                                                                                                                           understood
                                                                                                                           that
                                                                                                                           for
                                                                                                                           the
                                                                                                                           purposes
                                                                                                                           of
                                                                                                                           Section 1.15,
                                                                                                                           Section
                                                                                                                           11.2.1
                                                                                                                           and
                                                                                                                           Article 12,
                                                                                                                           Neurotrope’s
                                                                                                                           obligations
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           the
                                                                                                                           A Round
                                                                                                                           Financing
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           be
                                                                                                                           considered
                                                                                                                           satisfied,
                                                                                                                           and
                                                                                                                           the
                                                                                                                           A Round
                                                                                                                           Financing
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           be
                                                                                                                           considered
                                                                                                                           completed,
                                                                                                                           until
                                                                                                                           the
                                                                                                                           Net
                                                                                                                           Amount
                                                                                                                           of
                                                                                                                           such
                                                                                                                           proceeds
                                                                                                                           is
                                                                                                                           equal
                                                                                                                           to
                                                                                                                           or
                                                                                                                           greater
                                                                                                                           than
                                                                                                                           eight
                                                                                                                           million
                                                                                                                           dollars
                                                                                                                           ($8,000,000)
                                                                                                                           (or
                                                                                                                           such
                                                                                                                           other
                                                                                                                           amount
                                                                                                                           as
                                                                                                                           agreed
                                                                                                                           by
                                                                                                                           a unanimous
                                                                                                                           vote
                                                                                                                           of
                                                                                                                           all
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Directors
                                                                                                                           (as
                                                                                                                           defined
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Stockholders
                                                                                                                           Agreement)
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Board
                                                                                                                           (as
                                                                                                                           defined
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Stockholders
                                                                                                                           Agreement)).

 

		1.5	B
                                                                                                                           Round
                                                                                                                           Financing.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “B
                                                                                                                           Round
                                                                                                                           Financing”
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           equity
                                                                                                                           financing
                                                                                                                           from
                                                                                                                           the
                                                                                                                           sale
                                                                                                                           of
                                                                                                                           Series
                                                                                                                           B Preferred
                                                                                                                           Stock
                                                                                                                           of
                                                                                                                           Neurotrope,
                                                                                                                           par
                                                                                                                           value
                                                                                                                           $0.01
                                                                                                                           per
                                                                                                                           share
                                                                                                                           from
                                                                                                                           and
                                                                                                                           after
                                                                                                                           the
                                                                                                                           conclusion
                                                                                                                           of
                                                                                                                           the
                                                                                                                           A Round
                                                                                                                           Financing,
                                                                                                                           which
                                                                                                                           B Round
                                                                                                                           Financing
                                                                                                                           is
                                                                                                                           contemplated
                                                                                                                           to
                                                                                                                           close
                                                                                                                           on
                                                                                                                           the
                                                                                                                           earlier
                                                                                                                           of
                                                                                                                           (i)
                                                                                                                           the
                                                                                                                           actual
                                                                                                                           receipt
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           of
                                                                                                                           an
                                                                                                                           amount
                                                                                                                           equal
                                                                                                                           to
                                                                                                                           twenty-five
                                                                                                                           million
                                                                                                                           dollars
                                                                                                                           ($25,000,000)
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           twenty-four
                                                                                                                           (24)
                                                                                                                           months
                                                                                                                           following
                                                                                                                           the
                                                                                                                           conclusion
                                                                                                                           of
                                                                                                                           the
                                                                                                                           A Round
                                                                                                                           Financing.

 

		1.6	BRNI.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “BRNI”
                                                                                                                           shall
                                                                                                                           have
                                                                                                                           the
                                                                                                                           meaning
                                                                                                                           set
                                                                                                                           forth
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Preamble.

 

		1.7	BRNI
                                                                                                                           Data.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “BRNI
                                                                                                                           Data”
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           all
                                                                                                                           data,
                                                                                                                           reports,
                                                                                                                           documentation
                                                                                                                           and
                                                                                                                           information
                                                                                                                           (and
                                                                                                                           all
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           therein)
                                                                                                                           related
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP,
                                                                                                                           the
                                                                                                                           Services
                                                                                                                           or
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           including:
                                                                                                                           (i)
                                                                                                                           all
                                                                                                                           data,
                                                                                                                           reports,
                                                                                                                           documentation
                                                                                                                           and
                                                                                                                           information
                                                                                                                           related
                                                                                                                           to
                                                                                                                           actual
                                                                                                                           and
                                                                                                                           planned
                                                                                                                           pre-clinical
                                                                                                                           or
                                                                                                                           clinical
                                                                                                                           activities
                                                                                                                           or
                                                                                                                           trials
                                                                                                                           (including
                                                                                                                           pre-clinical
                                                                                                                           and
                                                                                                                           clinical
                                                                                                                           data
                                                                                                                           and
                                                                                                                           reports,
                                                                                                                           autopsy
                                                                                                                           data
                                                                                                                           and
                                                                                                                           reports,
                                                                                                                           case
                                                                                                                           report
                                                                                                                           forms,
                                                                                                                           un-blinded
                                                                                                                           data,
                                                                                                                           statistical
                                                                                                                           planning,
                                                                                                                           IRBs,
                                                                                                                           shipping
                                                                                                                           SOPs,
                                                                                                                           shipping
                                                                                                                           costs,
                                                                                                                           other
                                                                                                                           costs,
                                                                                                                           Swedish
                                                                                                                           OLINC
                                                                                                                           interface,
                                                                                                                           communications
                                                                                                                           with
                                                                                                                           Governmental
                                                                                                                           Authorities,
                                                                                                                           and
                                                                                                                           records
                                                                                                                           required
                                                                                                                           to
                                                                                                                           be
                                                                                                                           maintained
                                                                                                                           under
                                                                                                                           applicable
                                                                                                                           Laws);
                                                                                                                           (ii)
                                                                                                                           all
                                                                                                                           statistical
                                                                                                                           models
                                                                                                                           for
                                                                                                                           actual
                                                                                                                           and
                                                                                                                           planned
                                                                                                                           pre-clinical
                                                                                                                           or
                                                                                                                           clinical
                                                                                                                           activities
                                                                                                                           or
                                                                                                                           trials;
                                                                                                                           (iii)
                                                                                                                           all
                                                                                                                           autopsy
                                                                                                                           criteria
                                                                                                                           for
                                                                                                                           diagnosis;
                                                                                                                           and
                                                                                                                           (iv)
                                                                                                                           all
                                                                                                                           marketing
                                                                                                                           and
                                                                                                                           product
                                                                                                                           development-related
                                                                                                                           research
                                                                                                                           information
                                                                                                                           and
                                                                                                                           documentation.

 

    	 

    	 

    

 

		1.8	BRNI
                                                                                                                           Indemnitees.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “BRNI
                                                                                                                           Indemnitees”
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           BRNI,
                                                                                                                           its
                                                                                                                           Affiliates
                                                                                                                           (including
                                                                                                                           NRV
                                                                                                                           II,
                                                                                                                           but
                                                                                                                           excluding
                                                                                                                           Neurotrope),
                                                                                                                           and
                                                                                                                           its
                                                                                                                           and
                                                                                                                           their
                                                                                                                           respective
                                                                                                                           directors,
                                                                                                                           officers,
                                                                                                                           employees
                                                                                                                           and
                                                                                                                           agents.

 

		1.9	Claiming
                                                                                                                           Indemnitee.
                                                                                                                           The
                                                                                                                           term
                                                                                                                           “Claiming
                                                                                                                           Indemnitee”
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           a BRNI
                                                                                                                           Indemnitee
                                                                                                                           or
                                                                                                                           Neurotrope
                                                                                                                           Indemnitee,
                                                                                                                           as
                                                                                                                           applicable,
                                                                                                                           who
                                                                                                                           seeks
                                                                                                                           indemnification
                                                                                                                           under
                                                                                                                           Section
                                                                                                                           10.1.

 

		1.10	Confidential
                                                                                                                            Information.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Confidential
                                                                                                                            Information”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            all
                                                                                                                            confidential
                                                                                                                            and
                                                                                                                            proprietary
                                                                                                                            information
                                                                                                                            of
                                                                                                                            a
                                                                                                                            Party
                                                                                                                            (whether
                                                                                                                            or
                                                                                                                            not
                                                                                                                            specifically
                                                                                                                            labeled
                                                                                                                            or
                                                                                                                            identified
                                                                                                                            as
                                                                                                                            “confidential,”
                                                                                                                            whether
                                                                                                                            disclosed
                                                                                                                            directly
                                                                                                                            or
                                                                                                                            indirectly
                                                                                                                            in
                                                                                                                            writing,
                                                                                                                            by
                                                                                                                            oral
                                                                                                                            communications,
                                                                                                                            or
                                                                                                                            by
                                                                                                                            inspection
                                                                                                                            or
                                                                                                                            analysis
                                                                                                                            of
                                                                                                                            samples,
                                                                                                                            biomarkers,
                                                                                                                            DNA,
                                                                                                                            genes,
                                                                                                                            cells,
                                                                                                                            tissues,
                                                                                                                            or
                                                                                                                            other
                                                                                                                            tangible
                                                                                                                            objects,
                                                                                                                            and
                                                                                                                            in
                                                                                                                            any
                                                                                                                            form
                                                                                                                            or
                                                                                                                            medium),
                                                                                                                            including
                                                                                                                            (i)
                                                                                                                            the
                                                                                                                            terms
                                                                                                                            and
                                                                                                                            conditions
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            (ii)
                                                                                                                            BRNI
                                                                                                                            Data
                                                                                                                            and
                                                                                                                            Licensed
                                                                                                                            Technology,
                                                                                                                            and
                                                                                                                            (iii)
                                                                                                                            other
                                                                                                                            trade
                                                                                                                            secrets,
                                                                                                                            know-how,
                                                                                                                            data,
                                                                                                                            databases,
                                                                                                                            analyses,
                                                                                                                            techniques,
                                                                                                                            technologies,
                                                                                                                            systems,
                                                                                                                            formulae,
                                                                                                                            formulations,
                                                                                                                            discoveries,
                                                                                                                            research,
                                                                                                                            development,
                                                                                                                            actual
                                                                                                                            or
                                                                                                                            planned
                                                                                                                            pre-clinical
                                                                                                                            or
                                                                                                                            clinical
                                                                                                                            activities
                                                                                                                            or
                                                                                                                            trials
                                                                                                                            (and
                                                                                                                            the
                                                                                                                            results
                                                                                                                            thereof),
                                                                                                                            records,
                                                                                                                            reports,
                                                                                                                            manuals,
                                                                                                                            documentation,
                                                                                                                            models,
                                                                                                                            files,
                                                                                                                            confidential
                                                                                                                            inventions,
                                                                                                                            innovations,
                                                                                                                            improvements,
                                                                                                                            developments,
                                                                                                                            methods,
                                                                                                                            processes,
                                                                                                                            designs,
                                                                                                                            drawings,
                                                                                                                            reports,
                                                                                                                            documentation,
                                                                                                                            prototypes
                                                                                                                            and
                                                                                                                            all
                                                                                                                            similar
                                                                                                                            or
                                                                                                                            related
                                                                                                                            information,
                                                                                                                            whether
                                                                                                                            or
                                                                                                                            not
                                                                                                                            patentable.

 

		1.11	CREATE
                                                                                                                            Act.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “CREATE
                                                                                                                            Act”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            Cooperative
                                                                                                                            Research
                                                                                                                            and
                                                                                                                            Technology
                                                                                                                            Enhancement
                                                                                                                            Act
                                                                                                                            (35
                                                                                                                            U.S.C.
                                                                                                                            §103(c)).

 

		1.12	Disclosing
                                                                                                                            Party.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Disclosing
                                                                                                                            Party”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            Party
                                                                                                                            that
                                                                                                                            discloses
                                                                                                                            Confidential
                                                                                                                            Information
                                                                                                                            to
                                                                                                                            any
                                                                                                                            other
                                                                                                                            Party
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            this
                                                                                                                            Agreement.

 

		1.13	Dispute.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Dispute”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            any
                                                                                                                            dispute,
                                                                                                                            controversy,
                                                                                                                            or
                                                                                                                            claim
                                                                                                                            arising
                                                                                                                            out
                                                                                                                            of,
                                                                                                                            or
                                                                                                                            relating
                                                                                                                            to,
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            including
                                                                                                                            any
                                                                                                                            dispute,
                                                                                                                            controversy,
                                                                                                                            or
                                                                                                                            claim
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            the
                                                                                                                            interpretation
                                                                                                                            of
                                                                                                                            any
                                                                                                                            provision
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            the
                                                                                                                            performance
                                                                                                                            of
                                                                                                                            any
                                                                                                                            Party
                                                                                                                            of
                                                                                                                            its
                                                                                                                            obligations
                                                                                                                            under
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            and
                                                                                                                            situations
                                                                                                                            or
                                                                                                                            circumstances
                                                                                                                            in
                                                                                                                            which
                                                                                                                            the
                                                                                                                            Parties
                                                                                                                            shall,
                                                                                                                            but
                                                                                                                            cannot,
                                                                                                                            agree.

 

		1.14	Dispute
                                                                                                                            Resolution
                                                                                                                            Procedure.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Dispute
                                                                                                                            Resolution
                                                                                                                            Procedure”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            procedures
                                                                                                                            for
                                                                                                                            resolving
                                                                                                                            Disputes
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            Section
                                                                                                                            13.3.

 

		1.15	Effective
                                                                                                                            Date.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Effective
                                                                                                                            Date”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            date
                                                                                                                            on
                                                                                                                            which
                                                                                                                            Neurotrope
                                                                                                                            completes
                                                                                                                            the
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing.

 

		1.16	Execution
                                                                                                                            Date.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Execution
                                                                                                                            Date”
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            meaning
                                                                                                                            set
                                                                                                                            forth
                                                                                                                            in
                                                                                                                            the
                                                                                                                            Preamble.

 

    	 

    	 

    

 

		1.17	FDA.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “FDA”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            United
                                                                                                                            States
                                                                                                                            Food
                                                                                                                            and
                                                                                                                            Drug
                                                                                                                            Administration
                                                                                                                            or
                                                                                                                            any
                                                                                                                            successor
                                                                                                                            entity
                                                                                                                            thereto,
                                                                                                                            and
                                                                                                                            any
                                                                                                                            similar
                                                                                                                            Governmental
                                                                                                                            Authority
                                                                                                                            outside
                                                                                                                            of
                                                                                                                            the
                                                                                                                            United
                                                                                                                            States.

 

		1.18	Field
                                                                                                                            of
                                                                                                                            Use.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Field
                                                                                                                            of
                                                                                                                            Use”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            field
                                                                                                                            of
                                                                                                                            use
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            IP
                                                                                                                            in
                                                                                                                            humans
                                                                                                                            or
                                                                                                                            animals
                                                                                                                            for
                                                                                                                            therapeutic
                                                                                                                            or
                                                                                                                            diagnostic
                                                                                                                            applications
                                                                                                                            for
                                                                                                                            Alzheimer’s
                                                                                                                            Disease
                                                                                                                            or
                                                                                                                            other
                                                                                                                            cognitive
                                                                                                                            dysfunctions.

 

		1.19	Fixed
                                                                                                                            Research
                                                                                                                            Fee.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Fixed
                                                                                                                            Research
                                                                                                                            Fee”
                                                                                                                            shall
                                                                                                                            mean:
                                                                                                                            (i)
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            the
                                                                                                                            calendar
                                                                                                                            year
                                                                                                                            of
                                                                                                                            the
                                                                                                                            completion
                                                                                                                            of
                                                                                                                            the
                                                                                                                            B
                                                                                                                            Round
                                                                                                                            Financing,
                                                                                                                            the
                                                                                                                            pro-rata
                                                                                                                            amount
                                                                                                                            of
                                                                                                                            one
                                                                                                                            million
                                                                                                                            dollars
                                                                                                                            ($1,000,000)
                                                                                                                            for
                                                                                                                            such
                                                                                                                            calendar
                                                                                                                            year;
                                                                                                                            (ii)
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            each
                                                                                                                            of
                                                                                                                            the
                                                                                                                            five
                                                                                                                            (5)
                                                                                                                            calendar
                                                                                                                            years
                                                                                                                            following
                                                                                                                            the
                                                                                                                            calendar
                                                                                                                            year
                                                                                                                            of
                                                                                                                            the
                                                                                                                            completion
                                                                                                                            of
                                                                                                                            the
                                                                                                                            B
                                                                                                                            Round
                                                                                                                            Financing,
                                                                                                                            the
                                                                                                                            amount
                                                                                                                            of
                                                                                                                            one
                                                                                                                            million
                                                                                                                            dollars
                                                                                                                            ($1,000,000),
                                                                                                                            in
                                                                                                                            each
                                                                                                                            case
                                                                                                                            whether
                                                                                                                            or
                                                                                                                            not
                                                                                                                            Neurotrope
                                                                                                                            engages
                                                                                                                            BRNI
                                                                                                                            for
                                                                                                                            Services
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            Article
                                                                                                                            3
                                                                                                                            for
                                                                                                                            such
                                                                                                                            calendar
                                                                                                                            year;
                                                                                                                            and
                                                                                                                            (iii)
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            any
                                                                                                                            other
                                                                                                                            calendar
                                                                                                                            year,
                                                                                                                            such
                                                                                                                            amount
                                                                                                                            as
                                                                                                                            agreed
                                                                                                                            by
                                                                                                                            the
                                                                                                                            Parties.

 

		1.20	Force
                                                                                                                            Majeure
                                                                                                                            Event.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Force
                                                                                                                            Majeure
                                                                                                                            Event”
                                                                                                                            shall
                                                                                                                            mean,
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            a
                                                                                                                            delay
                                                                                                                            or
                                                                                                                            failure
                                                                                                                            to
                                                                                                                            perform
                                                                                                                            by
                                                                                                                            a
                                                                                                                            Party,
                                                                                                                            an
                                                                                                                            event
                                                                                                                            that
                                                                                                                            is
                                                                                                                            beyond
                                                                                                                            the
                                                                                                                            reasonable
                                                                                                                            control
                                                                                                                            of
                                                                                                                            such
                                                                                                                            Party,
                                                                                                                            including
                                                                                                                            (i)
                                                                                                                            acts
                                                                                                                            of
                                                                                                                            war,
                                                                                                                            terrorism,
                                                                                                                            civil
                                                                                                                            riots
                                                                                                                            and
                                                                                                                            unrest,
                                                                                                                            rebellions,
                                                                                                                            strikes,
                                                                                                                            labor
                                                                                                                            disputes,
                                                                                                                            (ii)
                                                                                                                            quarantines,
                                                                                                                            embargos
                                                                                                                            and
                                                                                                                            other
                                                                                                                            similar
                                                                                                                            unusual
                                                                                                                            governmental
                                                                                                                            actions,
                                                                                                                            and
                                                                                                                            (iii)
                                                                                                                            extraordinary
                                                                                                                            elements
                                                                                                                            of
                                                                                                                            nature,
                                                                                                                            fires,
                                                                                                                            earthquakes,
                                                                                                                            tsunamis,
                                                                                                                            and
                                                                                                                            acts
                                                                                                                            of
                                                                                                                            God.

 

		1.21	GAAP.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “GAAP”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            then-current
                                                                                                                            generally
                                                                                                                            accepted
                                                                                                                            accounting
                                                                                                                            principles
                                                                                                                            in
                                                                                                                            the
                                                                                                                            United
                                                                                                                            States
                                                                                                                            as
                                                                                                                            established
                                                                                                                            by
                                                                                                                            the
                                                                                                                            Financial
                                                                                                                            Accounting
                                                                                                                            Standards
                                                                                                                            Board
                                                                                                                            or
                                                                                                                            any
                                                                                                                            successor
                                                                                                                            entity
                                                                                                                            or
                                                                                                                            other
                                                                                                                            entity
                                                                                                                            generally
                                                                                                                            recognized
                                                                                                                            as
                                                                                                                            having
                                                                                                                            the
                                                                                                                            right
                                                                                                                            to
                                                                                                                            establish
                                                                                                                            such
                                                                                                                            principles,
                                                                                                                            in
                                                                                                                            each
                                                                                                                            case
                                                                                                                            consistently
                                                                                                                            applied.

 

		1.22	Governmental
                                                                                                                            Authority.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Governmental
                                                                                                                            Authority”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            any
                                                                                                                            federal,
                                                                                                                            state,
                                                                                                                            multinational,
                                                                                                                            provincial,
                                                                                                                            municipal,
                                                                                                                            local,
                                                                                                                            territorial,
                                                                                                                            or
                                                                                                                            other
                                                                                                                            governmental
                                                                                                                            department,
                                                                                                                            governmental
                                                                                                                            or
                                                                                                                            regulatory
                                                                                                                            authority,
                                                                                                                            court
                                                                                                                            or
                                                                                                                            judicial
                                                                                                                            or
                                                                                                                            administrative
                                                                                                                            body,
                                                                                                                            of
                                                                                                                            competent
                                                                                                                            jurisdiction,
                                                                                                                            whether
                                                                                                                            domestic,
                                                                                                                            foreign,
                                                                                                                            or
                                                                                                                            international,
                                                                                                                            including
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            foregoing
                                                                                                                            with
                                                                                                                            authority
                                                                                                                            over
                                                                                                                            the
                                                                                                                            research,
                                                                                                                            development,
                                                                                                                            manufacturing,
                                                                                                                            commercialization
                                                                                                                            or
                                                                                                                            other
                                                                                                                            use
                                                                                                                            (including
                                                                                                                            the
                                                                                                                            granting
                                                                                                                            of
                                                                                                                            marketing
                                                                                                                            approvals)
                                                                                                                            of
                                                                                                                            any
                                                                                                                            diagnosis
                                                                                                                            or
                                                                                                                            therapeutics
                                                                                                                            of
                                                                                                                            human
                                                                                                                            diseases
                                                                                                                            in
                                                                                                                            any
                                                                                                                            jurisdiction
                                                                                                                            (such
                                                                                                                            as
                                                                                                                            the
                                                                                                                            FDA).

 

		1.23	Indemnifying
                                                                                                                            Party.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Indemnifying
                                                                                                                            Party”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            BRNI
                                                                                                                            or
                                                                                                                            Neurotrope,
                                                                                                                            as
                                                                                                                            applicable,
                                                                                                                            who
                                                                                                                            is
                                                                                                                            obligated
                                                                                                                            to
                                                                                                                            indemnify
                                                                                                                            a
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            under
                                                                                                                            Section
                                                                                                                            10.1.

 

		1.24	Improvements.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Improvements”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            all
                                                                                                                            Intellectual
                                                                                                                            Property
                                                                                                                            that
                                                                                                                            includes,
                                                                                                                            or
                                                                                                                            is
                                                                                                                            based
                                                                                                                            in
                                                                                                                            whole
                                                                                                                            or
                                                                                                                            in
                                                                                                                            part
                                                                                                                            on,
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            IP,
                                                                                                                            including
                                                                                                                            any
                                                                                                                            improvements,
                                                                                                                            modifications,
                                                                                                                            enhancements
                                                                                                                            and
                                                                                                                            derivative
                                                                                                                            works
                                                                                                                            thereof
                                                                                                                            and
                                                                                                                            substitutes
                                                                                                                            therefor.

 

		1.25	Infringement.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Infringement”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            any
                                                                                                                            infringement,
                                                                                                                            misappropriation
                                                                                                                            or
                                                                                                                            conflict
                                                                                                                            with
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            IP
                                                                                                                            by
                                                                                                                            any
                                                                                                                            Person.

 

    	 

    	 

    

 

		1.26	Intellectual
                                                                                                                            Property.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Intellectual
                                                                                                                            Property”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            any
                                                                                                                            and
                                                                                                                            all
                                                                                                                            of
                                                                                                                            the
                                                                                                                            intellectual
                                                                                                                            property
                                                                                                                            and
                                                                                                                            proprietary
                                                                                                                            rights
                                                                                                                            (except
                                                                                                                            for
                                                                                                                            trademarks
                                                                                                                            and
                                                                                                                            service
                                                                                                                            marks)
                                                                                                                            in
                                                                                                                            any
                                                                                                                            jurisdiction
                                                                                                                            throughout
                                                                                                                            the
                                                                                                                            world,
                                                                                                                            including:
                                                                                                                            (i)
                                                                                                                            inventions
                                                                                                                            and
                                                                                                                            ideas
                                                                                                                            (whether
                                                                                                                            or
                                                                                                                            not
                                                                                                                            patentable
                                                                                                                            or
                                                                                                                            reduced
                                                                                                                            to
                                                                                                                            practice),
                                                                                                                            patents,
                                                                                                                            patent
                                                                                                                            applications,
                                                                                                                            and
                                                                                                                            patent
                                                                                                                            disclosures
                                                                                                                            and
                                                                                                                            improvements
                                                                                                                            thereto,
                                                                                                                            together
                                                                                                                            with
                                                                                                                            all
                                                                                                                            continuations,
                                                                                                                            continuations
                                                                                                                            in
                                                                                                                            part,
                                                                                                                            reissues,
                                                                                                                            renewals,
                                                                                                                            reexaminations,
                                                                                                                            provisionals,
                                                                                                                            divisionals,
                                                                                                                            extensions,
                                                                                                                            revisions
                                                                                                                            or
                                                                                                                            improvements
                                                                                                                            thereof,
                                                                                                                            any
                                                                                                                            foreign
                                                                                                                            counterparts
                                                                                                                            or
                                                                                                                            equivalents
                                                                                                                            of
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            foregoing;
                                                                                                                            (ii)
                                                                                                                            copyrights
                                                                                                                            and
                                                                                                                            works
                                                                                                                            of
                                                                                                                            authorship,
                                                                                                                            whether
                                                                                                                            registered
                                                                                                                            or
                                                                                                                            unregistered,
                                                                                                                            and
                                                                                                                            all
                                                                                                                            registrations
                                                                                                                            and
                                                                                                                            applications
                                                                                                                            for
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            foregoing,
                                                                                                                            and
                                                                                                                            all
                                                                                                                            associated
                                                                                                                            moral
                                                                                                                            rights;
                                                                                                                            (iii)
                                                                                                                            trade
                                                                                                                            secrets,
                                                                                                                            know-how,
                                                                                                                            and
                                                                                                                            other
                                                                                                                            confidential
                                                                                                                            and
                                                                                                                            proprietary
                                                                                                                            information;
                                                                                                                            and
                                                                                                                            (iv) samples,
                                                                                                                            biomarkers,
                                                                                                                            DNA,
                                                                                                                            genes,
                                                                                                                            cells,
                                                                                                                            and
                                                                                                                            tissues.

 

		1.27	Law.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Law”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            all
                                                                                                                            statutes,
                                                                                                                            regulations,
                                                                                                                            directives,
                                                                                                                            ordinances,
                                                                                                                            orders,
                                                                                                                            rulings,
                                                                                                                            agency
                                                                                                                            or
                                                                                                                            court
                                                                                                                            interpretations,
                                                                                                                            or
                                                                                                                            other
                                                                                                                            action
                                                                                                                            of
                                                                                                                            any
                                                                                                                            Governmental
                                                                                                                            Authority
                                                                                                                            in
                                                                                                                            any
                                                                                                                            jurisdiction
                                                                                                                            in
                                                                                                                            the
                                                                                                                            world,
                                                                                                                            whether
                                                                                                                            currently
                                                                                                                            in
                                                                                                                            force
                                                                                                                            or
                                                                                                                            enacted
                                                                                                                            during
                                                                                                                            the
                                                                                                                            Term.

 

		1.28	Licensed
                                                                                                                            IP.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Licensed
                                                                                                                            IP”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            Patents
                                                                                                                            and
                                                                                                                            Licensed
                                                                                                                            Technology.

 

		1.29	Licensed
                                                                                                                            Patents.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Licensed
                                                                                                                            Patents”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            claims
                                                                                                                            of
                                                                                                                            any
                                                                                                                            issued
                                                                                                                            patent
                                                                                                                            owned
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            or
                                                                                                                            licensed
                                                                                                                            to
                                                                                                                            NRV
                                                                                                                            II
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            on
                                                                                                                            or
                                                                                                                            subsequent
                                                                                                                            to
                                                                                                                            the
                                                                                                                            Effective
                                                                                                                            Date,
                                                                                                                            to
                                                                                                                            the
                                                                                                                            extent
                                                                                                                            that
                                                                                                                            such
                                                                                                                            claims
                                                                                                                            cover
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            Technology.

 

		1.30	Licensed
                                                                                                                            Products.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Licensed
                                                                                                                            Products”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            any
                                                                                                                            products
                                                                                                                            or
                                                                                                                            services
                                                                                                                            that
                                                                                                                            (i)
                                                                                                                            practice,
                                                                                                                            use,
                                                                                                                            embody,
                                                                                                                            are
                                                                                                                            based
                                                                                                                            on,
                                                                                                                            incorporate
                                                                                                                            or
                                                                                                                            utilize
                                                                                                                            any
                                                                                                                            Licensed
                                                                                                                            IP
                                                                                                                            or
                                                                                                                            (ii) but
                                                                                                                            for
                                                                                                                            the
                                                                                                                            license
                                                                                                                            and
                                                                                                                            sublicense
                                                                                                                            granted
                                                                                                                            under
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            infringe,
                                                                                                                            misappropriate
                                                                                                                            or
                                                                                                                            otherwise
                                                                                                                            violate
                                                                                                                            any
                                                                                                                            Licensed
                                                                                                                            IP.

 

		1.31	Licensed
                                                                                                                            Technology.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Licensed
                                                                                                                            Technology”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            all
                                                                                                                            trade
                                                                                                                            secrets,
                                                                                                                            know-how,
                                                                                                                            and
                                                                                                                            other
                                                                                                                            confidential
                                                                                                                            and
                                                                                                                            proprietary
                                                                                                                            information
                                                                                                                            owned
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            or
                                                                                                                            licensed
                                                                                                                            to
                                                                                                                            NRV
                                                                                                                            II
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            on
                                                                                                                            or
                                                                                                                            subsequent
                                                                                                                            to
                                                                                                                            the
                                                                                                                            Effective
                                                                                                                            Date,
                                                                                                                            to
                                                                                                                            the
                                                                                                                            extent
                                                                                                                            covering
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            following:

 

		(i)	an in vitro therapeutic test system that uses cultured human fibroblasts or any other method to
detect and measure PKC and/or other assays with peripheral cells to predict the presence of Alzheimer’s Disease in humans,
and all succeeding test formats (including test kits);

 

		(ii)	the PKC activators (including bryostatin, analogs, PUFAs, and other PKC activators) and their therapeutic
applications in humans or animals;

 

		(iii)	the LDL or ApoE-based drug delivery system that is targeted to enhance access of all manner of
drugs and therapeutics to the brain by facilitation of transport of such drugs across the Blood-Brain-Barrier in humans or animals;
and

 

		(iv)	the carbonic anhydrase activators and their therapeutic applications in humans or animals.

 

    	 

    	 

    

 

		1.32	Losses.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Losses”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            claims,
                                                                                                                            liabilities,
                                                                                                                            costs,
                                                                                                                            expenses,
                                                                                                                            damages,
                                                                                                                            deficiencies,
                                                                                                                            losses,
                                                                                                                            or
                                                                                                                            obligations
                                                                                                                            of
                                                                                                                            any
                                                                                                                            kind
                                                                                                                            or
                                                                                                                            nature
                                                                                                                            (including
                                                                                                                            reasonable
                                                                                                                            attorney’s
                                                                                                                            fees
                                                                                                                            and
                                                                                                                            other
                                                                                                                            costs
                                                                                                                            and
                                                                                                                            expenses
                                                                                                                            of
                                                                                                                            litigation).

 

		1.33	Net
                                                                                                                            Amount.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Net
                                                                                                                            Amount”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            amount
                                                                                                                            of
                                                                                                                            capital
                                                                                                                            raised
                                                                                                                            by
                                                                                                                            Neurotrope
                                                                                                                            in
                                                                                                                            the
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing,
                                                                                                                            less
                                                                                                                            all
                                                                                                                            costs
                                                                                                                            and
                                                                                                                            expenses
                                                                                                                            incurred
                                                                                                                            by
                                                                                                                            Neurotrope
                                                                                                                            in
                                                                                                                            connection
                                                                                                                            the
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing,
                                                                                                                            including
                                                                                                                            attorneys’
                                                                                                                            fees
                                                                                                                            and
                                                                                                                            bankers’
                                                                                                                            fees.

 

		1.34	Neurotrope.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Neurotrope”
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            meaning
                                                                                                                            set
                                                                                                                            forth
                                                                                                                            in
                                                                                                                            the
                                                                                                                            Preamble.

 

		1.35	Neurotrope
                                                                                                                            Indemnitees.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Neurotrope
                                                                                                                            Indemnitees”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            Neurotrope
                                                                                                                            and
                                                                                                                            its
                                                                                                                            directors,
                                                                                                                            officers,
                                                                                                                            employees
                                                                                                                            and
                                                                                                                            agents.

 

		1.36	Neurotrope
                                                                                                                            Technology.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Neurotrope
                                                                                                                            Technology”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            Intellectual
                                                                                                                            Property
                                                                                                                            created
                                                                                                                            by
                                                                                                                            Neurotrope
                                                                                                                            during
                                                                                                                            the
                                                                                                                            Term
                                                                                                                            outside
                                                                                                                            the
                                                                                                                            scope
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement.
                                                                                                                            For
                                                                                                                            the
                                                                                                                            avoidance
                                                                                                                            of
                                                                                                                            doubt,
                                                                                                                            Neurotrope
                                                                                                                            Technology
                                                                                                                            shall
                                                                                                                            not
                                                                                                                            include
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            IP,
                                                                                                                            Improvements
                                                                                                                            or
                                                                                                                            Confidential
                                                                                                                            Information
                                                                                                                            of
                                                                                                                            BRNI
                                                                                                                            or
                                                                                                                            NRV
                                                                                                                            II.

 

		1.37	NRV
                                                                                                                            II.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “NRV
                                                                                                                            II”
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            meaning
                                                                                                                            set
                                                                                                                            forth
                                                                                                                            in
                                                                                                                            the
                                                                                                                            Preamble.

 

		1.38	Party
                                                                                                                            or
                                                                                                                            Parties.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Party”
                                                                                                                            or
                                                                                                                            “Parties”
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            meaning
                                                                                                                            set
                                                                                                                            forth
                                                                                                                            in
                                                                                                                            the
                                                                                                                            Preamble.

 

		1.39	Person.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Person”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            an
                                                                                                                            individual,
                                                                                                                            a
                                                                                                                            partnership,
                                                                                                                            a
                                                                                                                            corporation,
                                                                                                                            a
                                                                                                                            limited
                                                                                                                            liability
                                                                                                                            company,
                                                                                                                            an
                                                                                                                            association,
                                                                                                                            a
                                                                                                                            joint
                                                                                                                            stock
                                                                                                                            company,
                                                                                                                            a
                                                                                                                            trust,
                                                                                                                            a
                                                                                                                            joint
                                                                                                                            venture,
                                                                                                                            an
                                                                                                                            unincorporated
                                                                                                                            organization
                                                                                                                            and
                                                                                                                            a
                                                                                                                            Governmental
                                                                                                                            Authority
                                                                                                                            or
                                                                                                                            any
                                                                                                                            department,
                                                                                                                            agency
                                                                                                                            or
                                                                                                                            political
                                                                                                                            subdivision
                                                                                                                            thereof.

 

		1.40	Prime
                                                                                                                            Rate.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Prime
                                                                                                                            Rate”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            prime
                                                                                                                            rate
                                                                                                                            as
                                                                                                                            published
                                                                                                                            in
                                                                                                                            the
                                                                                                                            Wall
                                                                                                                            Street
                                                                                                                            Journal
                                                                                                                            or,
                                                                                                                            failing
                                                                                                                            such
                                                                                                                            publication,
                                                                                                                            such
                                                                                                                            other
                                                                                                                            interest
                                                                                                                            rate
                                                                                                                            as
                                                                                                                            may
                                                                                                                            replace
                                                                                                                            or
                                                                                                                            supersede
                                                                                                                            the
                                                                                                                            same
                                                                                                                            or,
                                                                                                                            in
                                                                                                                            the
                                                                                                                            absence
                                                                                                                            of
                                                                                                                            a
                                                                                                                            replacement
                                                                                                                            or
                                                                                                                            superseding
                                                                                                                            interest,
                                                                                                                            such
                                                                                                                            other
                                                                                                                            interest
                                                                                                                            as
                                                                                                                            the
                                                                                                                            Parties
                                                                                                                            may
                                                                                                                            agree.

 

		1.41	Purchase
                                                                                                                            Agreements.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Purchase
                                                                                                                            Agreements”
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            meaning
                                                                                                                            set
                                                                                                                            forth
                                                                                                                            in
                                                                                                                            the
                                                                                                                            Preamble.

 

		1.42	Quarter.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Quarter”
                                                                                                                            shall
                                                                                                                            mean,
                                                                                                                            during
                                                                                                                            the
                                                                                                                            Term
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            each
                                                                                                                            calendar
                                                                                                                            quarter,
                                                                                                                            with
                                                                                                                            any
                                                                                                                            partial
                                                                                                                            calendar
                                                                                                                            quarter
                                                                                                                            commencing
                                                                                                                            on
                                                                                                                            the
                                                                                                                            Effective
                                                                                                                            Date
                                                                                                                            being
                                                                                                                            included
                                                                                                                            within
                                                                                                                            the
                                                                                                                            first
                                                                                                                            full
                                                                                                                            calendar
                                                                                                                            quarter
                                                                                                                            after
                                                                                                                            the
                                                                                                                            Effective
                                                                                                                            Date
                                                                                                                            as
                                                                                                                            the
                                                                                                                            first
                                                                                                                            “Quarter,”
                                                                                                                            and
                                                                                                                            any
                                                                                                                            partial
                                                                                                                            calendar
                                                                                                                            quarter
                                                                                                                            being
                                                                                                                            included
                                                                                                                            within
                                                                                                                            the
                                                                                                                            last
                                                                                                                            full
                                                                                                                            calendar
                                                                                                                            quarter
                                                                                                                            including
                                                                                                                            the
                                                                                                                            date
                                                                                                                            of
                                                                                                                            termination
                                                                                                                            or
                                                                                                                            expiration
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Term
                                                                                                                            as
                                                                                                                            the
                                                                                                                            last
                                                                                                                            “Quarter.”

 

		1.43	Receiving
                                                                                                                            Party.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Receiving
                                                                                                                            Party”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            Party
                                                                                                                            that
                                                                                                                            receives
                                                                                                                            Confidential
                                                                                                                            Information
                                                                                                                            from
                                                                                                                            another
                                                                                                                            Party
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            this
                                                                                                                            Agreement.

 

		1.44	Records.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Records”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            books
                                                                                                                            of
                                                                                                                            account
                                                                                                                            and
                                                                                                                            records
                                                                                                                            relating
                                                                                                                            to
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            (including
                                                                                                                            all
                                                                                                                            records
                                                                                                                            of
                                                                                                                            transactions
                                                                                                                            relating
                                                                                                                            to
                                                                                                                            Licensed
                                                                                                                            Products,
                                                                                                                            Revenues,
                                                                                                                            and
                                                                                                                            sublicenses).

 

    	 

    	 

    

 

		1.45	Revenues.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Revenues”
                                                                                                                            shall
                                                                                                                            mean,
                                                                                                                            during
                                                                                                                            any
                                                                                                                            given
                                                                                                                            period,
                                                                                                                            as
                                                                                                                            determined
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            GAAP:
                                                                                                                            (i)
                                                                                                                            gross
                                                                                                                            revenues
                                                                                                                            of
                                                                                                                            any
                                                                                                                            kind
                                                                                                                            accrued,
                                                                                                                            due
                                                                                                                            or
                                                                                                                            owing
                                                                                                                            to
                                                                                                                            Neurotrope
                                                                                                                            (directly
                                                                                                                            or
                                                                                                                            indirectly)
                                                                                                                            or
                                                                                                                            any
                                                                                                                            of
                                                                                                                            its
                                                                                                                            sublicensees
                                                                                                                            (directly
                                                                                                                            or
                                                                                                                            indirectly)
                                                                                                                            in
                                                                                                                            connection
                                                                                                                            with
                                                                                                                            any
                                                                                                                            Licensed
                                                                                                                            Products
                                                                                                                            sold
                                                                                                                            or
                                                                                                                            otherwise
                                                                                                                            provided
                                                                                                                            by
                                                                                                                            or
                                                                                                                            for
                                                                                                                            Neurotrope
                                                                                                                            or
                                                                                                                            its
                                                                                                                            sublicensees
                                                                                                                            during
                                                                                                                            such
                                                                                                                            period,
                                                                                                                            and
                                                                                                                            (ii)
                                                                                                                            gross
                                                                                                                            up-front
                                                                                                                            fees,
                                                                                                                            royalties,
                                                                                                                            licensing
                                                                                                                            or
                                                                                                                            sublicensing
                                                                                                                            fees,
                                                                                                                            milestone
                                                                                                                            payments,
                                                                                                                            lump
                                                                                                                            sum
                                                                                                                            payments
                                                                                                                            and
                                                                                                                            other
                                                                                                                            amounts
                                                                                                                            of
                                                                                                                            any
                                                                                                                            kind
                                                                                                                            accrued,
                                                                                                                            due
                                                                                                                            or
                                                                                                                            owing
                                                                                                                            to
                                                                                                                            Neurotrope
                                                                                                                            in
                                                                                                                            connection
                                                                                                                            with
                                                                                                                            any
                                                                                                                            Licensed
                                                                                                                            IP.

 

		1.46	Royalty.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Royalty”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            a
                                                                                                                            royalty
                                                                                                                            equal
                                                                                                                            to
                                                                                                                            the
                                                                                                                            Royalty
                                                                                                                            Rate
                                                                                                                            times
                                                                                                                            Revenues.

 

		1.47	Royalty
                                                                                                                            Rate.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Royalty
                                                                                                                            Rate”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            applicable
                                                                                                                            percentage,
                                                                                                                            as
                                                                                                                            determined
                                                                                                                            by
                                                                                                                            the
                                                                                                                            percentage
                                                                                                                            of
                                                                                                                            NRV
                                                                                                                            I’s
                                                                                                                            equity
                                                                                                                            ownership
                                                                                                                            of
                                                                                                                            Neurotrope
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            the
                                                                                                                            Stockholders
                                                                                                                            Agreement,
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            the
                                                                                                                            following
                                                                                                                            table:

 

	Percentage of NRV I’s Equity Ownership of Neurotrope	Royalty Rate
	Greater than or equal to 47.5%	2.0%
	Greater than or equal to 45.0% and less than 47.5%	2.5%
	Greater than or equal to 40.0% and less than 45.0%	3.0%
	Greater than or equal to 35.0% and less than 40.0%	3.5%
	Greater than or equal to 30.0% and less than 35.0%	4.0%
	Greater than or equal to 25.0% and less than 30.0%	4.5%
	Less than 25.0%	5.0%

 

 

		1.48	Services.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Services”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            research
                                                                                                                            and
                                                                                                                            development
                                                                                                                            services
                                                                                                                            and
                                                                                                                            other
                                                                                                                            related
                                                                                                                            scientific
                                                                                                                            assistance
                                                                                                                            and
                                                                                                                            support
                                                                                                                            services
                                                                                                                            (including
                                                                                                                            pre-clinical
                                                                                                                            or
                                                                                                                            clinical
                                                                                                                            activities
                                                                                                                            or
                                                                                                                            trials)
                                                                                                                            set
                                                                                                                            forth
                                                                                                                            in
                                                                                                                            an
                                                                                                                            SOW
                                                                                                                            to
                                                                                                                            be
                                                                                                                            provided
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            to
                                                                                                                            Neurotrope
                                                                                                                            under
                                                                                                                            this
                                                                                                                            Agreement.

 

		1.49	Services
                                                                                                                            Fees.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Services
                                                                                                                            Fees”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            costs
                                                                                                                            and
                                                                                                                            expenses
                                                                                                                            incurred
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            or
                                                                                                                            its
                                                                                                                            Affiliates
                                                                                                                            in
                                                                                                                            connection
                                                                                                                            with
                                                                                                                            the
                                                                                                                            Services
                                                                                                                            and
                                                                                                                            the
                                                                                                                            fees
                                                                                                                            for
                                                                                                                            Services
                                                                                                                            calculated
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            the
                                                                                                                            applicable
                                                                                                                            SOW.

 

		1.50	Services
                                                                                                                            Reimbursement.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Services
                                                                                                                            Reimbursement”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            four
                                                                                                                            million
                                                                                                                            dollars
                                                                                                                            ($4,000,000),
                                                                                                                            pro-rated
                                                                                                                            on
                                                                                                                            a
                                                                                                                            thirty
                                                                                                                            (30)
                                                                                                                            month
                                                                                                                            basis
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            the
                                                                                                                            period
                                                                                                                            of
                                                                                                                            time
                                                                                                                            elapsed
                                                                                                                            from
                                                                                                                            April
                                                                                                                            2,
                                                                                                                            2012
                                                                                                                            through
                                                                                                                            the
                                                                                                                            date
                                                                                                                            of
                                                                                                                            completion
                                                                                                                            of
                                                                                                                            the
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing.
                                                                                                                            For
                                                                                                                            example,
                                                                                                                            if
                                                                                                                            the
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing
                                                                                                                            is
                                                                                                                            completed
                                                                                                                            on:

 

		(i)	October 2, 2012, the Services Reimbursement shall be equal to (6 months / 30 months) * $4,000,000
(or $800,000); and

 

		(ii)	July 2, 2013, the Services Reimbursement shall be equal to (15 months / 30 months) * $4,000,000
(or $2,000,000).

 

    	 

    	 

    

 

		1.51	SOW.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “SOW”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            a
                                                                                                                            statement
                                                                                                                            of
                                                                                                                            work
                                                                                                                            entered
                                                                                                                            into
                                                                                                                            between
                                                                                                                            BRNI
                                                                                                                            and
                                                                                                                            Neurotrope
                                                                                                                            in
                                                                                                                            connection
                                                                                                                            with
                                                                                                                            this
                                                                                                                            Agreement.

 

		1.52	Stockholders
                                                                                                                            Agreement.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Stockholders
                                                                                                                            Agreement”
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            meaning
                                                                                                                            set
                                                                                                                            forth
                                                                                                                            in
                                                                                                                            the
                                                                                                                            Preamble.

 

		1.53	Term.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Term”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            the
                                                                                                                            later
                                                                                                                            of
                                                                                                                            the
                                                                                                                            date
                                                                                                                            (i)
                                                                                                                            the
                                                                                                                            last
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            Patents
                                                                                                                            expires,
                                                                                                                            is
                                                                                                                            abandoned,
                                                                                                                            or
                                                                                                                            is
                                                                                                                            declared
                                                                                                                            unenforceable
                                                                                                                            or
                                                                                                                            invalid
                                                                                                                            and
                                                                                                                            (ii)
                                                                                                                            the
                                                                                                                            last
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            Technology
                                                                                                                            enters
                                                                                                                            the
                                                                                                                            public
                                                                                                                            domain.
                                                                                                                            For
                                                                                                                            the
                                                                                                                            purposes
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            the
                                                                                                                            expiration,
                                                                                                                            abandonment,
                                                                                                                            or
                                                                                                                            declaration
                                                                                                                            of
                                                                                                                            unenforceability
                                                                                                                            or
                                                                                                                            invalidity
                                                                                                                            of
                                                                                                                            a
                                                                                                                            Licensed
                                                                                                                            Patent
                                                                                                                            occurs
                                                                                                                            in
                                                                                                                            the
                                                                                                                            event
                                                                                                                            of:
                                                                                                                            (a)
                                                                                                                            irrevocable
                                                                                                                            lapse
                                                                                                                            for
                                                                                                                            failure
                                                                                                                            to
                                                                                                                            pay
                                                                                                                            maintenance
                                                                                                                            fees;
                                                                                                                            (b)
                                                                                                                            final
                                                                                                                            rejection
                                                                                                                            of
                                                                                                                            the
                                                                                                                            applicable
                                                                                                                            claims
                                                                                                                            by
                                                                                                                            the
                                                                                                                            United
                                                                                                                            States
                                                                                                                            Patent
                                                                                                                            and
                                                                                                                            Trademark
                                                                                                                            Office
                                                                                                                            or
                                                                                                                            applicable
                                                                                                                            foreign
                                                                                                                            patent
                                                                                                                            office
                                                                                                                            and
                                                                                                                            the
                                                                                                                            exhaustion
                                                                                                                            or
                                                                                                                            expiration
                                                                                                                            of
                                                                                                                            all
                                                                                                                            appeals
                                                                                                                            of
                                                                                                                            such
                                                                                                                            rejection;
                                                                                                                            or
                                                                                                                            (c)
                                                                                                                            final
                                                                                                                            adjudication
                                                                                                                            by
                                                                                                                            a
                                                                                                                            court
                                                                                                                            of
                                                                                                                            competent
                                                                                                                            jurisdiction
                                                                                                                            that
                                                                                                                            the
                                                                                                                            applicable
                                                                                                                            claims
                                                                                                                            of
                                                                                                                            the
                                                                                                                            such
                                                                                                                            Licensed
                                                                                                                            Patent
                                                                                                                            are
                                                                                                                            invalid
                                                                                                                            or
                                                                                                                            unenforceable
                                                                                                                            and
                                                                                                                            the
                                                                                                                            exhaustion
                                                                                                                            or
                                                                                                                            expiration
                                                                                                                            of
                                                                                                                            all
                                                                                                                            appeals
                                                                                                                            from
                                                                                                                            such
                                                                                                                            adjudication.

 

		1.54	Third
                                                                                                                            Party.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Third
                                                                                                                            Party”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            any
                                                                                                                            Person
                                                                                                                            other
                                                                                                                            than
                                                                                                                            the
                                                                                                                            Parties.

 

		1.55	Third
                                                                                                                            Party
                                                                                                                            Claims.
                                                                                                                            The
                                                                                                                            term
                                                                                                                            “Third
                                                                                                                            Party
                                                                                                                            Claims”
                                                                                                                            shall
                                                                                                                            mean
                                                                                                                            any
                                                                                                                            actual
                                                                                                                            or
                                                                                                                            threatened
                                                                                                                            Action
                                                                                                                            of
                                                                                                                            any
                                                                                                                            Third
                                                                                                                            Party.

 

		2.	Licenses

 

		2.1	Grant
                                                                                                                           of
                                                                                                                           License.
                                                                                                                           Subject
                                                                                                                           to
                                                                                                                           the
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           effective
                                                                                                                           as
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Effective
                                                                                                                           Date,
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           NRV
                                                                                                                           II
                                                                                                                           hereby
                                                                                                                           grant
                                                                                                                           to
                                                                                                                           Neurotrope,
                                                                                                                           the
                                                                                                                           exclusive
                                                                                                                           (except
                                                                                                                           as
                                                                                                                           set
                                                                                                                           forth
                                                                                                                           in
                                                                                                                           Section
                                                                                                                           2.3),
                                                                                                                           non-transferable
                                                                                                                           (except
                                                                                                                           as
                                                                                                                           permitted
                                                                                                                           by
                                                                                                                           Section
                                                                                                                           13.1),
                                                                                                                           worldwide,
                                                                                                                           royalty-bearing
                                                                                                                           right
                                                                                                                           (including
                                                                                                                           a license
                                                                                                                           from
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           a sublicense
                                                                                                                           from
                                                                                                                           NRV
                                                                                                                           II)
                                                                                                                           under
                                                                                                                           their
                                                                                                                           respective
                                                                                                                           right,
                                                                                                                           title
                                                                                                                           and
                                                                                                                           interest
                                                                                                                           in
                                                                                                                           and
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Patents
                                                                                                                           and
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Technology
                                                                                                                           to
                                                                                                                           develop,
                                                                                                                           use,
                                                                                                                           manufacture
                                                                                                                           (for
                                                                                                                           the
                                                                                                                           avoidance
                                                                                                                           of
                                                                                                                           doubt,
                                                                                                                           but
                                                                                                                           not
                                                                                                                           to
                                                                                                                           have
                                                                                                                           manufactured
                                                                                                                           except
                                                                                                                           as
                                                                                                                           permitted
                                                                                                                           by
                                                                                                                           Section
                                                                                                                           2.2),
                                                                                                                           market,
                                                                                                                           offer
                                                                                                                           for
                                                                                                                           sale,
                                                                                                                           sell,
                                                                                                                           distribute,
                                                                                                                           import
                                                                                                                           and
                                                                                                                           export
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products
                                                                                                                           during
                                                                                                                           the
                                                                                                                           Term,
                                                                                                                           in
                                                                                                                           each
                                                                                                                           case,
                                                                                                                           solely
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Field
                                                                                                                           of
                                                                                                                           Use.

 

		2.2	Right
                                                                                                                           to
                                                                                                                           Sublicense.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           have
                                                                                                                           no
                                                                                                                           right
                                                                                                                           to
                                                                                                                           sublicense
                                                                                                                           the
                                                                                                                           rights
                                                                                                                           granted
                                                                                                                           in
                                                                                                                           Section
                                                                                                                           2.1
                                                                                                                           to
                                                                                                                           a Third
                                                                                                                           Party,
                                                                                                                           without
                                                                                                                           the
                                                                                                                           prior
                                                                                                                           written
                                                                                                                           consent
                                                                                                                           of
                                                                                                                           BRNI.
                                                                                                                           Any
                                                                                                                           such
                                                                                                                           permitted
                                                                                                                           sublicense:
                                                                                                                           (i)
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           subject
                                                                                                                           to
                                                                                                                           the
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement;
                                                                                                                           (ii)
                                                                                                                           shall
                                                                                                                           expressly
                                                                                                                           exclude
                                                                                                                           the
                                                                                                                           right
                                                                                                                           to
                                                                                                                           sublicense;
                                                                                                                           and
                                                                                                                           (iii)
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           made
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           a written
                                                                                                                           agreement
                                                                                                                           between
                                                                                                                           Neurotrope
                                                                                                                           and
                                                                                                                           such
                                                                                                                           sublicensee
                                                                                                                           providing
                                                                                                                           that
                                                                                                                           Neurotrope’s
                                                                                                                           obligations
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           binding
                                                                                                                           upon
                                                                                                                           such
                                                                                                                           sublicensee
                                                                                                                           as
                                                                                                                           if
                                                                                                                           such
                                                                                                                           sublicensee
                                                                                                                           were
                                                                                                                           a party
                                                                                                                           to
                                                                                                                           this
                                                                                                                           Agreement.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           liable
                                                                                                                           and
                                                                                                                           responsible
                                                                                                                           for,
                                                                                                                           and
                                                                                                                           shall
                                                                                                                           assume
                                                                                                                           all
                                                                                                                           liabilities
                                                                                                                           and
                                                                                                                           responsibilities
                                                                                                                           for,
                                                                                                                           the
                                                                                                                           acts
                                                                                                                           or
                                                                                                                           omissions
                                                                                                                           of
                                                                                                                           its
                                                                                                                           sublicensees
                                                                                                                           and
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           grant
                                                                                                                           any
                                                                                                                           rights
                                                                                                                           that
                                                                                                                           are
                                                                                                                           inconsistent
                                                                                                                           with
                                                                                                                           the
                                                                                                                           rights
                                                                                                                           granted
                                                                                                                           to,
                                                                                                                           and
                                                                                                                           obligations
                                                                                                                           of,
                                                                                                                           Neurotrope
                                                                                                                           hereunder.
                                                                                                                           Any
                                                                                                                           act
                                                                                                                           or
                                                                                                                           omission
                                                                                                                           of
                                                                                                                           a sublicensee
                                                                                                                           that
                                                                                                                           would
                                                                                                                           be
                                                                                                                           a breach
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           if
                                                                                                                           performed
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           deemed
                                                                                                                           to
                                                                                                                           be
                                                                                                                           a breach
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           by
                                                                                                                           Neurotrope.
                                                                                                                           No
                                                                                                                           sublicense
                                                                                                                           agreement
                                                                                                                           granted
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           contain
                                                                                                                           any
                                                                                                                           provision
                                                                                                                           which
                                                                                                                           would
                                                                                                                           cause
                                                                                                                           such
                                                                                                                           sublicense
                                                                                                                           agreement
                                                                                                                           to
                                                                                                                           extend
                                                                                                                           beyond
                                                                                                                           the
                                                                                                                           Term
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement.

 

    	 

    	 

    

 

Without limiting any other provision
of this Section 2.2, each sublicense agreement must expressly provide that: (i) all Intellectual Property developed, conceived
of, or created in connection with, such sublicense agreement shall be assigned to BRNI; (ii) the sublicensee shall be bound by
confidentiality obligations that are no less stringent than those set forth in Article 7 with respect to all Confidential
Information of BRNI, NRV II and Neurotrope; and (iii) BRNI and, if applicable, NRV II are intended Third Party beneficiaries of
such sublicense agreement. Neurotrope shall promptly supply BRNI with a copy of each sublicense agreement for BRNI’s review
prior to such agreement being executed.

 

		2.3	Exceptions
                                                                                                                           to
                                                                                                                           Exclusivity.
                                                                                                                           Notwithstanding
                                                                                                                           anything
                                                                                                                           to
                                                                                                                           the
                                                                                                                           contrary
                                                                                                                           contained
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Agreement:
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           its
                                                                                                                           Affiliates
                                                                                                                           may
                                                                                                                           use
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Field
                                                                                                                           of
                                                                                                                           Use
                                                                                                                           (a)
                                                                                                                           to
                                                                                                                           engage
                                                                                                                           in
                                                                                                                           research
                                                                                                                           and
                                                                                                                           development
                                                                                                                           and
                                                                                                                           other
                                                                                                                           non-commercial
                                                                                                                           activities
                                                                                                                           and
                                                                                                                           (b)
                                                                                                                           to
                                                                                                                           provide
                                                                                                                           Services
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           or
                                                                                                                           to
                                                                                                                           perform
                                                                                                                           any
                                                                                                                           other
                                                                                                                           activities
                                                                                                                           in
                                                                                                                           connection
                                                                                                                           with
                                                                                                                           this
                                                                                                                           Agreement.
                                                                                                                           Notwithstanding
                                                                                                                           anything
                                                                                                                           to
                                                                                                                           the
                                                                                                                           contrary
                                                                                                                           contained
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           if,
                                                                                                                           subsequent
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Execution
                                                                                                                           Date,
                                                                                                                           BRNI
                                                                                                                           or
                                                                                                                           NRV
                                                                                                                           II
                                                                                                                           acquires
                                                                                                                           any
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           that
                                                                                                                           would
                                                                                                                           otherwise
                                                                                                                           constitute
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           and
                                                                                                                           such
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           is
                                                                                                                           subject
                                                                                                                           to
                                                                                                                           a license
                                                                                                                           existing
                                                                                                                           as
                                                                                                                           of
                                                                                                                           the
                                                                                                                           date
                                                                                                                           of
                                                                                                                           acquisition
                                                                                                                           thereof,
                                                                                                                           then
                                                                                                                           (I)
                                                                                                                           to
                                                                                                                           the
                                                                                                                           extent
                                                                                                                           such
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           is
                                                                                                                           licensed
                                                                                                                           on
                                                                                                                           an
                                                                                                                           exclusive
                                                                                                                           or
                                                                                                                           sole
                                                                                                                           basis
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           such
                                                                                                                           license
                                                                                                                           existing
                                                                                                                           as
                                                                                                                           of
                                                                                                                           the
                                                                                                                           date
                                                                                                                           of
                                                                                                                           such
                                                                                                                           acquisition,
                                                                                                                           such
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           (a) deemed
                                                                                                                           to
                                                                                                                           not
                                                                                                                           be
                                                                                                                           Licensed
                                                                                                                           Technology
                                                                                                                           or
                                                                                                                           Licensed
                                                                                                                           Patents,
                                                                                                                           as
                                                                                                                           applicable,
                                                                                                                           and
                                                                                                                           (b) excluded
                                                                                                                           from
                                                                                                                           the
                                                                                                                           rights
                                                                                                                           granted
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           (including
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           Section 2.1);
                                                                                                                           and
                                                                                                                           (II)
                                                                                                                           to
                                                                                                                           the
                                                                                                                           extent
                                                                                                                           such
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           is
                                                                                                                           not
                                                                                                                           licensed
                                                                                                                           on
                                                                                                                           an
                                                                                                                           exclusive
                                                                                                                           or
                                                                                                                           sole
                                                                                                                           basis
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           such
                                                                                                                           license
                                                                                                                           existing
                                                                                                                           as
                                                                                                                           of
                                                                                                                           the
                                                                                                                           date
                                                                                                                           of
                                                                                                                           such
                                                                                                                           acquisition,
                                                                                                                           such
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           deemed
                                                                                                                           to
                                                                                                                           be
                                                                                                                           Licensed
                                                                                                                           Technology
                                                                                                                           or
                                                                                                                           Licensed
                                                                                                                           Patents,
                                                                                                                           as
                                                                                                                           applicable,
                                                                                                                           provided
                                                                                                                           that
                                                                                                                           all
                                                                                                                           rights
                                                                                                                           granted
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           such
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           deemed
                                                                                                                           to
                                                                                                                           be
                                                                                                                           non-exclusive
                                                                                                                           and
                                                                                                                           subject
                                                                                                                           to
                                                                                                                           the
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           of
                                                                                                                           the
                                                                                                                           agreement
                                                                                                                           granting
                                                                                                                           such
                                                                                                                           license.

 

		2.4	No
                                                                                                                           Implied
                                                                                                                           Licenses.
                                                                                                                           No
                                                                                                                           different,
                                                                                                                           other
                                                                                                                           or
                                                                                                                           further
                                                                                                                           right
                                                                                                                           or
                                                                                                                           license,
                                                                                                                           other
                                                                                                                           than
                                                                                                                           what
                                                                                                                           is
                                                                                                                           granted
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           2,
                                                                                                                           is
                                                                                                                           intended
                                                                                                                           or
                                                                                                                           granted
                                                                                                                           by
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           whether
                                                                                                                           by
                                                                                                                           express
                                                                                                                           or
                                                                                                                           implied
                                                                                                                           means
                                                                                                                           or
                                                                                                                           by
                                                                                                                           estoppel,
                                                                                                                           and
                                                                                                                           this
                                                                                                                           is
                                                                                                                           not
                                                                                                                           an
                                                                                                                           assignment
                                                                                                                           by
                                                                                                                           BRNI
                                                                                                                           or
                                                                                                                           NRV
                                                                                                                           II
                                                                                                                           of
                                                                                                                           any
                                                                                                                           right,
                                                                                                                           title
                                                                                                                           or
                                                                                                                           interest
                                                                                                                           in
                                                                                                                           any
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP.
                                                                                                                           Any
                                                                                                                           right
                                                                                                                           or
                                                                                                                           interest
                                                                                                                           not
                                                                                                                           expressly
                                                                                                                           granted
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           2
                                                                                                                           is
                                                                                                                           reserved
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           NRV
                                                                                                                           II,
                                                                                                                           including
                                                                                                                           all
                                                                                                                           rights
                                                                                                                           and
                                                                                                                           interests
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           outside
                                                                                                                           the
                                                                                                                           Field
                                                                                                                           of
                                                                                                                           Use.
                                                                                                                           As
                                                                                                                           between
                                                                                                                           Neurotrope,
                                                                                                                           on
                                                                                                                           the
                                                                                                                           one
                                                                                                                           hand,
                                                                                                                           and
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           NRV
                                                                                                                           II,
                                                                                                                           on
                                                                                                                           the
                                                                                                                           other
                                                                                                                           hand,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           the
                                                                                                                           exclusive
                                                                                                                           owner
                                                                                                                           of
                                                                                                                           all
                                                                                                                           Neurotrope
                                                                                                                           Technology
                                                                                                                           (but
                                                                                                                           only
                                                                                                                           to
                                                                                                                           the
                                                                                                                           extent
                                                                                                                           created
                                                                                                                           without
                                                                                                                           the
                                                                                                                           use
                                                                                                                           of
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           Technology,
                                                                                                                           Licensed
                                                                                                                           Patents,
                                                                                                                           Improvements
                                                                                                                           or
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           BRNI
                                                                                                                           or
                                                                                                                           NRV
                                                                                                                           II).

 

		2.5	Restrictions.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           not,
                                                                                                                           and
                                                                                                                           shall
                                                                                                                           cause
                                                                                                                           its
                                                                                                                           sublicensees
                                                                                                                           not
                                                                                                                           to,
                                                                                                                           use
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           outside
                                                                                                                           of
                                                                                                                           the
                                                                                                                           scope
                                                                                                                           of
                                                                                                                           the
                                                                                                                           licenses
                                                                                                                           granted
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           2.

 

    	 

    	 

    

 

		3.	Services 

 

		3.1	Services. Neurotrope may, from time to time, submit request for Services in writing to BRNI,
setting forth in reasonable detail the nature of the Services requested. In the event that BRNI is able to provide such Services
and no Third Party is clearly in a superior position to provide services identical or similar to such Services, BRNI and Neurotrope
shall promptly: (i) discuss the Services requested and the related terms and conditions; and (ii) negotiate in good faith and execute
an SOW regarding terms and conditions of such Services. Upon execution of an SOW, BRNI shall provide, or shall cause its Affiliates
to provide, the applicable Services in accordance with such SOW.

 

		3.2	Preferred
                                                                                                                           Service
                                                                                                                           Provider.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           engage
                                                                                                                           any
                                                                                                                           Person
                                                                                                                           other
                                                                                                                           than
                                                                                                                           BRNI
                                                                                                                           to
                                                                                                                           provide
                                                                                                                           any
                                                                                                                           research
                                                                                                                           or
                                                                                                                           development
                                                                                                                           services
                                                                                                                           or
                                                                                                                           other
                                                                                                                           related
                                                                                                                           scientific
                                                                                                                           assistance
                                                                                                                           and
                                                                                                                           support
                                                                                                                           services
                                                                                                                           (including
                                                                                                                           pre-clinical
                                                                                                                           or
                                                                                                                           clinical
                                                                                                                           activities
                                                                                                                           or
                                                                                                                           trials),
                                                                                                                           including
                                                                                                                           any
                                                                                                                           services
                                                                                                                           identical
                                                                                                                           or
                                                                                                                           similar
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Services,
                                                                                                                           without
                                                                                                                           BRNI’s
                                                                                                                           prior
                                                                                                                           written
                                                                                                                           consent.
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           Neurotrope
                                                                                                                           may
                                                                                                                           agree
                                                                                                                           to
                                                                                                                           have
                                                                                                                           a Third
                                                                                                                           Party
                                                                                                                           provide
                                                                                                                           services
                                                                                                                           identical
                                                                                                                           or
                                                                                                                           similar
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Services
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           in
                                                                                                                           the
                                                                                                                           case
                                                                                                                           where
                                                                                                                           BRNI
                                                                                                                           is
                                                                                                                           demonstrably
                                                                                                                           unable
                                                                                                                           to
                                                                                                                           do
                                                                                                                           so
                                                                                                                           or
                                                                                                                           such
                                                                                                                           Third
                                                                                                                           Party
                                                                                                                           is
                                                                                                                           demonstrably
                                                                                                                           in
                                                                                                                           a superior
                                                                                                                           position
                                                                                                                           to
                                                                                                                           do
                                                                                                                           so.
                                                                                                                           Under
                                                                                                                           such
                                                                                                                           circumstances:
                                                                                                                           (i)
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           promptly
                                                                                                                           enter
                                                                                                                           into
                                                                                                                           an
                                                                                                                           agreement
                                                                                                                           with
                                                                                                                           such
                                                                                                                           Third
                                                                                                                           Party
                                                                                                                           regarding
                                                                                                                           the
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           for
                                                                                                                           such
                                                                                                                           services;
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           unless
                                                                                                                           BRNI
                                                                                                                           has
                                                                                                                           no
                                                                                                                           expertise
                                                                                                                           or
                                                                                                                           experience
                                                                                                                           relating
                                                                                                                           to
                                                                                                                           such
                                                                                                                           services,
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           promptly
                                                                                                                           negotiate
                                                                                                                           and
                                                                                                                           execute
                                                                                                                           an
                                                                                                                           SOW
                                                                                                                           regarding
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           of
                                                                                                                           Services
                                                                                                                           to
                                                                                                                           be
                                                                                                                           provided
                                                                                                                           by
                                                                                                                           BRNI
                                                                                                                           under
                                                                                                                           which
                                                                                                                           BRNI
                                                                                                                           will
                                                                                                                           work
                                                                                                                           closely
                                                                                                                           with
                                                                                                                           such
                                                                                                                           Third
                                                                                                                           Party
                                                                                                                           and
                                                                                                                           will
                                                                                                                           provide
                                                                                                                           support
                                                                                                                           for
                                                                                                                           such
                                                                                                                           Third
                                                                                                                           Party
                                                                                                                           services.

 

		4.	Payments

 

		4.1	Royalties
                                                                                                                           and
                                                                                                                           Other
                                                                                                                           Fees.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           pay:
                                                                                                                           (i)
                                                                                                                           to
                                                                                                                           BRNI,
                                                                                                                           on
                                                                                                                           BRNI’s
                                                                                                                           own
                                                                                                                           behalf
                                                                                                                           and
                                                                                                                           as
                                                                                                                           an
                                                                                                                           agent
                                                                                                                           for
                                                                                                                           NRV
                                                                                                                           II,
                                                                                                                           the
                                                                                                                           Royalty
                                                                                                                           (including
                                                                                                                           advances
                                                                                                                           on
                                                                                                                           future
                                                                                                                           Royalties),
                                                                                                                           to
                                                                                                                           be
                                                                                                                           allocated
                                                                                                                           between
                                                                                                                           NRV
                                                                                                                           II
                                                                                                                           and
                                                                                                                           BRNI
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           an
                                                                                                                           agreement
                                                                                                                           between
                                                                                                                           NRV
                                                                                                                           II
                                                                                                                           and
                                                                                                                           BRNI;
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           to
                                                                                                                           BRNI,
                                                                                                                           (a)
                                                                                                                           the
                                                                                                                           Fixed
                                                                                                                           Research
                                                                                                                           Fee,
                                                                                                                           (b)
                                                                                                                           the
                                                                                                                           Services
                                                                                                                           Reimbursement,
                                                                                                                           (c) the
                                                                                                                           Services
                                                                                                                           Fees
                                                                                                                           and
                                                                                                                           (d)
                                                                                                                           all
                                                                                                                           other
                                                                                                                           fees,
                                                                                                                           costs,
                                                                                                                           expenses
                                                                                                                           or
                                                                                                                           other
                                                                                                                           amounts
                                                                                                                           to
                                                                                                                           be
                                                                                                                           paid
                                                                                                                           or
                                                                                                                           reimbursed
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           in
                                                                                                                           each
                                                                                                                           case
                                                                                                                           in
                                                                                                                           accordance
                                                                                                                           with
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           4.
                                                                                                                           Upon
                                                                                                                           the
                                                                                                                           date
                                                                                                                           the
                                                                                                                           last
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Patents
                                                                                                                           expires,
                                                                                                                           is
                                                                                                                           abandoned,
                                                                                                                           or
                                                                                                                           is
                                                                                                                           declared
                                                                                                                           unenforceable
                                                                                                                           or
                                                                                                                           invalid,
                                                                                                                           the
                                                                                                                           Parties
                                                                                                                           shall
                                                                                                                           negotiate
                                                                                                                           in
                                                                                                                           good
                                                                                                                           faith
                                                                                                                           an
                                                                                                                           adjustment
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Royalty
                                                                                                                           Rate
                                                                                                                           for
                                                                                                                           the
                                                                                                                           remainder
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Term.

 

		4.2	Arms’
                                                                                                                           Length
                                                                                                                           Transaction.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           engage
                                                                                                                           in
                                                                                                                           all
                                                                                                                           transactions
                                                                                                                           related
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products
                                                                                                                           or
                                                                                                                           the
                                                                                                                           sublicenses
                                                                                                                           granted
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           in
                                                                                                                           the
                                                                                                                           ordinary
                                                                                                                           course
                                                                                                                           of
                                                                                                                           business
                                                                                                                           on
                                                                                                                           fair
                                                                                                                           and
                                                                                                                           reasonable
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           that
                                                                                                                           are
                                                                                                                           no
                                                                                                                           less
                                                                                                                           favorable
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           than
                                                                                                                           would
                                                                                                                           be
                                                                                                                           obtained
                                                                                                                           in
                                                                                                                           a comparable
                                                                                                                           arms’
                                                                                                                           length
                                                                                                                           transaction
                                                                                                                           between
                                                                                                                           Neurotrope
                                                                                                                           and
                                                                                                                           a Third
                                                                                                                           Party
                                                                                                                           that
                                                                                                                           is
                                                                                                                           not
                                                                                                                           an
                                                                                                                           Affiliate
                                                                                                                           of
                                                                                                                           Neurotrope.
                                                                                                                           Such
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           the
                                                                                                                           basis
                                                                                                                           for
                                                                                                                           calculation
                                                                                                                           of
                                                                                                                           Revenues.

 

		4.3	Advances
                                                                                                                           on
                                                                                                                           Future
                                                                                                                           Royalties.
                                                                                                                           Within
                                                                                                                           thirty
                                                                                                                           (30)
                                                                                                                           days
                                                                                                                           after
                                                                                                                           the
                                                                                                                           receipt
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           of
                                                                                                                           any
                                                                                                                           amount
                                                                                                                           of
                                                                                                                           capital
                                                                                                                           raised
                                                                                                                           in
                                                                                                                           the
                                                                                                                           A Round
                                                                                                                           Financing,
                                                                                                                           the
                                                                                                                           B Round
                                                                                                                           Financing,
                                                                                                                           or
                                                                                                                           any
                                                                                                                           subsequent
                                                                                                                           rounds
                                                                                                                           of
                                                                                                                           financing
                                                                                                                           prior
                                                                                                                           to
                                                                                                                           a public
                                                                                                                           offering,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           pay
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           five
                                                                                                                           percent
                                                                                                                           (5%)
                                                                                                                           of
                                                                                                                           such
                                                                                                                           amount
                                                                                                                           as
                                                                                                                           an
                                                                                                                           advance
                                                                                                                           payment
                                                                                                                           of
                                                                                                                           future
                                                                                                                           Royalty
                                                                                                                           payable
                                                                                                                           under
                                                                                                                           Section
                                                                                                                           4.5.
                                                                                                                           Such
                                                                                                                           advance
                                                                                                                           payment
                                                                                                                           of
                                                                                                                           future
                                                                                                                           Royalty
                                                                                                                           will
                                                                                                                           be
                                                                                                                           offset
                                                                                                                           (with
                                                                                                                           no
                                                                                                                           interest)
                                                                                                                           against
                                                                                                                           the
                                                                                                                           amount
                                                                                                                           of
                                                                                                                           Royalty
                                                                                                                           payable
                                                                                                                           under
                                                                                                                           Section
                                                                                                                           4.5
                                                                                                                           until
                                                                                                                           such
                                                                                                                           time
                                                                                                                           that
                                                                                                                           such
                                                                                                                           advance
                                                                                                                           payment
                                                                                                                           of
                                                                                                                           future
                                                                                                                           Royalty
                                                                                                                           equals
                                                                                                                           in
                                                                                                                           full
                                                                                                                           the
                                                                                                                           amount
                                                                                                                           of
                                                                                                                           the
                                                                                                                           advance
                                                                                                                           payment.

 

    	 

    	 

    

 

		4.4	Reimbursement.
                                                                                                                           Within
                                                                                                                           thirty
                                                                                                                           (30)
                                                                                                                           days
                                                                                                                           of
                                                                                                                           the
                                                                                                                           date
                                                                                                                           of
                                                                                                                           completion
                                                                                                                           of
                                                                                                                           the
                                                                                                                           A Round
                                                                                                                           Financing,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           pay
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           the
                                                                                                                           Services
                                                                                                                           Reimbursement.

 

		4.5	Royalty
                                                                                                                           Payments
                                                                                                                           and
                                                                                                                           Reports.
                                                                                                                           Within
                                                                                                                           sixty
                                                                                                                           (60)
                                                                                                                           days
                                                                                                                           after
                                                                                                                           the
                                                                                                                           end
                                                                                                                           of
                                                                                                                           each
                                                                                                                           Quarter,
                                                                                                                           Neurotrope
                                                                                                                           shall:
                                                                                                                           (i)
                                                                                                                           pay
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           the
                                                                                                                           Royalty
                                                                                                                           for
                                                                                                                           such
                                                                                                                           Quarter
                                                                                                                           in
                                                                                                                           accordance
                                                                                                                           with
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           4;
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           regardless
                                                                                                                           of
                                                                                                                           whether
                                                                                                                           any
                                                                                                                           payment
                                                                                                                           is
                                                                                                                           due,
                                                                                                                           provide
                                                                                                                           BRNI
                                                                                                                           with
                                                                                                                           a report
                                                                                                                           providing
                                                                                                                           (a)
                                                                                                                           details
                                                                                                                           of
                                                                                                                           Revenues
                                                                                                                           accrued
                                                                                                                           for
                                                                                                                           such
                                                                                                                           Quarter,
                                                                                                                           (b)
                                                                                                                           details
                                                                                                                           regarding
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products
                                                                                                                           sold
                                                                                                                           or
                                                                                                                           otherwise
                                                                                                                           provided
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           or
                                                                                                                           its
                                                                                                                           sublicensees
                                                                                                                           during
                                                                                                                           such
                                                                                                                           Quarter
                                                                                                                           (detailed
                                                                                                                           country-by-country,
                                                                                                                           with
                                                                                                                           gross
                                                                                                                           invoiced
                                                                                                                           amounts
                                                                                                                           and
                                                                                                                           Revenues),
                                                                                                                           (c)
                                                                                                                           details
                                                                                                                           regarding
                                                                                                                           up-front
                                                                                                                           fees,
                                                                                                                           royalties,
                                                                                                                           licensing
                                                                                                                           or
                                                                                                                           sublicensing
                                                                                                                           fees,
                                                                                                                           milestone
                                                                                                                           payments,
                                                                                                                           lump
                                                                                                                           sum
                                                                                                                           payments
                                                                                                                           and
                                                                                                                           other
                                                                                                                           amounts
                                                                                                                           accrued,
                                                                                                                           due
                                                                                                                           or
                                                                                                                           owing
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           or
                                                                                                                           its
                                                                                                                           sublicensees
                                                                                                                           for
                                                                                                                           such
                                                                                                                           Quarter,
                                                                                                                           and
                                                                                                                           (d)
                                                                                                                           a calculation
                                                                                                                           of
                                                                                                                           the
                                                                                                                           amount
                                                                                                                           of
                                                                                                                           Royalty
                                                                                                                           due
                                                                                                                           hereunder
                                                                                                                           for
                                                                                                                           such
                                                                                                                           Quarter.

 

		4.6	Fixed
                                                                                                                           Research
                                                                                                                           Fee.
                                                                                                                           With
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           the
                                                                                                                           calendar
                                                                                                                           year
                                                                                                                           of
                                                                                                                           the
                                                                                                                           completion
                                                                                                                           of
                                                                                                                           the
                                                                                                                           B Round
                                                                                                                           Financing,
                                                                                                                           within
                                                                                                                           ten
                                                                                                                           (10)
                                                                                                                           days
                                                                                                                           after
                                                                                                                           such
                                                                                                                           completion,
                                                                                                                           and
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           each
                                                                                                                           of
                                                                                                                           the
                                                                                                                           five
                                                                                                                           (5)
                                                                                                                           calendar
                                                                                                                           years
                                                                                                                           following
                                                                                                                           the
                                                                                                                           calendar
                                                                                                                           year
                                                                                                                           of
                                                                                                                           the
                                                                                                                           completion
                                                                                                                           of
                                                                                                                           the
                                                                                                                           B Round
                                                                                                                           Financing,
                                                                                                                           within
                                                                                                                           ten
                                                                                                                           (10)
                                                                                                                           days
                                                                                                                           after
                                                                                                                           the
                                                                                                                           beginning
                                                                                                                           of
                                                                                                                           each
                                                                                                                           such
                                                                                                                           calendar
                                                                                                                           year
                                                                                                                           after
                                                                                                                           the
                                                                                                                           completion
                                                                                                                           of
                                                                                                                           the
                                                                                                                           B Round
                                                                                                                           Financing,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           pay
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           the
                                                                                                                           Fixed
                                                                                                                           Research
                                                                                                                           Fee
                                                                                                                           for
                                                                                                                           such
                                                                                                                           calendar
                                                                                                                           year.
                                                                                                                           No
                                                                                                                           later
                                                                                                                           than
                                                                                                                           ninety
                                                                                                                           (90)
                                                                                                                           days
                                                                                                                           prior
                                                                                                                           to
                                                                                                                           the
                                                                                                                           end
                                                                                                                           of
                                                                                                                           the
                                                                                                                           fifth
                                                                                                                           (5th)
                                                                                                                           calendar
                                                                                                                           year
                                                                                                                           following
                                                                                                                           the
                                                                                                                           calendar
                                                                                                                           year
                                                                                                                           of
                                                                                                                           the
                                                                                                                           completion
                                                                                                                           of
                                                                                                                           the
                                                                                                                           B Round
                                                                                                                           Financing,
                                                                                                                           the
                                                                                                                           Parties
                                                                                                                           shall
                                                                                                                           negotiate
                                                                                                                           in
                                                                                                                           good
                                                                                                                           faith
                                                                                                                           the
                                                                                                                           amount
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Fixed
                                                                                                                           Research
                                                                                                                           Fee
                                                                                                                           for
                                                                                                                           each
                                                                                                                           remaining
                                                                                                                           calendar
                                                                                                                           year
                                                                                                                           during
                                                                                                                           the
                                                                                                                           Term.

 

		4.7	Services
                                                                                                                           Fees.
                                                                                                                           BRNI
                                                                                                                           will
                                                                                                                           provide
                                                                                                                           Neurotrope
                                                                                                                           with
                                                                                                                           monthly
                                                                                                                           invoices
                                                                                                                           for
                                                                                                                           Services
                                                                                                                           Fees
                                                                                                                           in
                                                                                                                           advance.
                                                                                                                           Such
                                                                                                                           invoice
                                                                                                                           shall
                                                                                                                           include
                                                                                                                           Services
                                                                                                                           Fees
                                                                                                                           estimated
                                                                                                                           to
                                                                                                                           be
                                                                                                                           incurred
                                                                                                                           for
                                                                                                                           the
                                                                                                                           next
                                                                                                                           month
                                                                                                                           and
                                                                                                                           a true-up
                                                                                                                           for
                                                                                                                           the
                                                                                                                           difference
                                                                                                                           between
                                                                                                                           the
                                                                                                                           estimated
                                                                                                                           Services
                                                                                                                           Fees
                                                                                                                           and
                                                                                                                           the
                                                                                                                           actual
                                                                                                                           Services
                                                                                                                           Fees
                                                                                                                           incurred
                                                                                                                           for
                                                                                                                           the
                                                                                                                           immediately
                                                                                                                           preceding
                                                                                                                           month.
                                                                                                                           Neurotrope
                                                                                                                           may
                                                                                                                           credit
                                                                                                                           against
                                                                                                                           the
                                                                                                                           Services
                                                                                                                           Fees
                                                                                                                           for
                                                                                                                           Services
                                                                                                                           performed
                                                                                                                           in
                                                                                                                           a particular
                                                                                                                           calendar
                                                                                                                           year
                                                                                                                           the
                                                                                                                           Fixed
                                                                                                                           Research
                                                                                                                           Fee
                                                                                                                           for
                                                                                                                           such
                                                                                                                           calendar
                                                                                                                           year.

 

		4.8	Payment
                                                                                                                           Method
                                                                                                                           and
                                                                                                                           Timing.
                                                                                                                           All
                                                                                                                           payments
                                                                                                                           made
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           made
                                                                                                                           in
                                                                                                                           U.S.
                                                                                                                           dollars.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           pay
                                                                                                                           all
                                                                                                                           sums
                                                                                                                           due
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           by
                                                                                                                           check,
                                                                                                                           wire
                                                                                                                           transfer,
                                                                                                                           or
                                                                                                                           electronic
                                                                                                                           funds
                                                                                                                           transfer
                                                                                                                           (EFT)
                                                                                                                           in
                                                                                                                           immediately
                                                                                                                           available
                                                                                                                           funds.
                                                                                                                           Except
                                                                                                                           as
                                                                                                                           expressly
                                                                                                                           set
                                                                                                                           forth
                                                                                                                           in
                                                                                                                           Section 5.6,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           pay
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           all
                                                                                                                           invoiced
                                                                                                                           amounts
                                                                                                                           within
                                                                                                                           thirty
                                                                                                                           (30)
                                                                                                                           days
                                                                                                                           after
                                                                                                                           the
                                                                                                                           date
                                                                                                                           of
                                                                                                                           the
                                                                                                                           applicable
                                                                                                                           invoice.

 

		4.9	Taxes.
                                                                                                                           Among
                                                                                                                           the
                                                                                                                           Parties,
                                                                                                                           all
                                                                                                                           taxes
                                                                                                                           relating
                                                                                                                           to
                                                                                                                           the
                                                                                                                           sale
                                                                                                                           or
                                                                                                                           provision
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           the
                                                                                                                           sole
                                                                                                                           responsibility
                                                                                                                           of
                                                                                                                           Neurotrope.
                                                                                                                           Each
                                                                                                                           Party
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           solely
                                                                                                                           responsible
                                                                                                                           for
                                                                                                                           its
                                                                                                                           own
                                                                                                                           income
                                                                                                                           taxes
                                                                                                                           based
                                                                                                                           on
                                                                                                                           the
                                                                                                                           amounts
                                                                                                                           received
                                                                                                                           in
                                                                                                                           connection
                                                                                                                           with
                                                                                                                           this
                                                                                                                           Agreement.

 

    	 

    	 

    

 

		4.10	Late
                                                                                                                            Payment.
                                                                                                                            Time
                                                                                                                            is
                                                                                                                            of
                                                                                                                            the
                                                                                                                            essence
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            all
                                                                                                                            payment
                                                                                                                            to
                                                                                                                            be
                                                                                                                            made
                                                                                                                            hereunder
                                                                                                                            by
                                                                                                                            Neurotrope.
                                                                                                                            Any
                                                                                                                            payments
                                                                                                                            or
                                                                                                                            portions
                                                                                                                            thereof
                                                                                                                            due
                                                                                                                            hereunder
                                                                                                                            which
                                                                                                                            are
                                                                                                                            not
                                                                                                                            paid
                                                                                                                            when
                                                                                                                            due
                                                                                                                            shall
                                                                                                                            bear
                                                                                                                            interest
                                                                                                                            equal
                                                                                                                            to
                                                                                                                            the
                                                                                                                            lesser
                                                                                                                            of
                                                                                                                            the
                                                                                                                            rate
                                                                                                                            equal
                                                                                                                            to
                                                                                                                            twenty-five
                                                                                                                            percent
                                                                                                                            (25%)
                                                                                                                            per
                                                                                                                            annum
                                                                                                                            above
                                                                                                                            the
                                                                                                                            Prime
                                                                                                                            Rate
                                                                                                                            or
                                                                                                                            the
                                                                                                                            maximum
                                                                                                                            rate
                                                                                                                            permitted
                                                                                                                            by
                                                                                                                            Law,
                                                                                                                            calculated
                                                                                                                            on
                                                                                                                            the
                                                                                                                            number
                                                                                                                            of
                                                                                                                            days
                                                                                                                            such
                                                                                                                            payment
                                                                                                                            is
                                                                                                                            delinquent.
                                                                                                                            This
                                                                                                                            Section
                                                                                                                            4.10
                                                                                                                            shall
                                                                                                                            in
                                                                                                                            no
                                                                                                                            way
                                                                                                                            limit
                                                                                                                            any
                                                                                                                            other
                                                                                                                            remedies
                                                                                                                            available
                                                                                                                            to
                                                                                                                            either
                                                                                                                            Party.

 

		4.11	Incorrect
                                                                                                                            Statements
                                                                                                                            or
                                                                                                                            Payment.
                                                                                                                            The
                                                                                                                            receipt
                                                                                                                            or
                                                                                                                            acceptance
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            of
                                                                                                                            any
                                                                                                                            amounts
                                                                                                                            under
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            shall
                                                                                                                            not
                                                                                                                            prevent
                                                                                                                            BRNI
                                                                                                                            from
                                                                                                                            challenging
                                                                                                                            the
                                                                                                                            validity
                                                                                                                            or
                                                                                                                            accuracy
                                                                                                                            thereof
                                                                                                                            at
                                                                                                                            any
                                                                                                                            time,
                                                                                                                            and
                                                                                                                            in
                                                                                                                            the
                                                                                                                            event
                                                                                                                            that
                                                                                                                            any
                                                                                                                            inconsistencies
                                                                                                                            or
                                                                                                                            mistakes
                                                                                                                            are
                                                                                                                            discovered
                                                                                                                            in
                                                                                                                            connection
                                                                                                                            therewith,
                                                                                                                            they
                                                                                                                            shall
                                                                                                                            immediately
                                                                                                                            be
                                                                                                                            rectified
                                                                                                                            and
                                                                                                                            the
                                                                                                                            appropriate
                                                                                                                            payment
                                                                                                                            made
                                                                                                                            by
                                                                                                                            Neurotrope
                                                                                                                            to
                                                                                                                            BRNI.

 

		4.12	Audits.
                                                                                                                            During
                                                                                                                            the
                                                                                                                            Term
                                                                                                                            and
                                                                                                                            for
                                                                                                                            at
                                                                                                                            least
                                                                                                                            three
                                                                                                                            (3)
                                                                                                                            years
                                                                                                                            after
                                                                                                                            the
                                                                                                                            expiration
                                                                                                                            or
                                                                                                                            termination
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            Neurotrope
                                                                                                                            shall
                                                                                                                            keep,
                                                                                                                            maintain
                                                                                                                            and
                                                                                                                            preserve
                                                                                                                            complete
                                                                                                                            and
                                                                                                                            accurate
                                                                                                                            Records
                                                                                                                            at
                                                                                                                            its
                                                                                                                            principal
                                                                                                                            place
                                                                                                                            of
                                                                                                                            business.
                                                                                                                            Upon
                                                                                                                            reasonable
                                                                                                                            notice
                                                                                                                            to
                                                                                                                            Neurotrope,
                                                                                                                            BRNI
                                                                                                                            (or
                                                                                                                            a
                                                                                                                            party
                                                                                                                            designated
                                                                                                                            by
                                                                                                                            BRNI)
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            right
                                                                                                                            to
                                                                                                                            audit
                                                                                                                            the
                                                                                                                            Records.
                                                                                                                            Such
                                                                                                                            audits
                                                                                                                            may
                                                                                                                            be
                                                                                                                            exercised
                                                                                                                            during
                                                                                                                            normal
                                                                                                                            business
                                                                                                                            hours
                                                                                                                            and
                                                                                                                            BRNI
                                                                                                                            (or
                                                                                                                            a
                                                                                                                            party
                                                                                                                            designated
                                                                                                                            by
                                                                                                                            BRNI)
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            right
                                                                                                                            to
                                                                                                                            make
                                                                                                                            copies
                                                                                                                            or
                                                                                                                            extracts
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Records.
                                                                                                                            Neurotrope
                                                                                                                            shall
                                                                                                                            pay
                                                                                                                            BRNI
                                                                                                                            for
                                                                                                                            the
                                                                                                                            cost
                                                                                                                            of
                                                                                                                            any
                                                                                                                            audit
                                                                                                                            that
                                                                                                                            discloses
                                                                                                                            (i)
                                                                                                                            an
                                                                                                                            intentional
                                                                                                                            payment
                                                                                                                            misreporting,
                                                                                                                            or
                                                                                                                            (ii)
                                                                                                                            a
                                                                                                                            payment
                                                                                                                            misreporting
                                                                                                                            of
                                                                                                                            more
                                                                                                                            than
                                                                                                                            two
                                                                                                                            percent
                                                                                                                            (2%)
                                                                                                                            between
                                                                                                                            the
                                                                                                                            amount
                                                                                                                            due
                                                                                                                            to
                                                                                                                            BRNI
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            the
                                                                                                                            audit
                                                                                                                            and
                                                                                                                            the
                                                                                                                            amount
                                                                                                                            Neurotrope
                                                                                                                            actually
                                                                                                                            paid
                                                                                                                            or
                                                                                                                            reported
                                                                                                                            to
                                                                                                                            BRNI.
                                                                                                                            Neurotrope
                                                                                                                            shall
                                                                                                                            promptly
                                                                                                                            make
                                                                                                                            corrective
                                                                                                                            payments
                                                                                                                            (together
                                                                                                                            with
                                                                                                                            interest
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            Section
                                                                                                                            4.10)
                                                                                                                            to
                                                                                                                            correct
                                                                                                                            any
                                                                                                                            underpayments
                                                                                                                            detected
                                                                                                                            in
                                                                                                                            any
                                                                                                                            such
                                                                                                                            audit.

 

		5.	Intellectual Property

 

		5.1	Licensed
                                                                                                                           IP.
                                                                                                                           Neurotrope
                                                                                                                           acknowledges
                                                                                                                           and
                                                                                                                           agrees
                                                                                                                           that:
                                                                                                                           (i)
                                                                                                                           all
                                                                                                                           right,
                                                                                                                           title
                                                                                                                           and
                                                                                                                           interest
                                                                                                                           in
                                                                                                                           and
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           owned
                                                                                                                           solely
                                                                                                                           and
                                                                                                                           exclusively
                                                                                                                           by
                                                                                                                           BRNI
                                                                                                                           (except
                                                                                                                           for
                                                                                                                           rights
                                                                                                                           granted
                                                                                                                           to
                                                                                                                           NRV
                                                                                                                           II);
                                                                                                                           (ii)
                                                                                                                           all
                                                                                                                           use
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           inure
                                                                                                                           to
                                                                                                                           the
                                                                                                                           benefit
                                                                                                                           of
                                                                                                                           BRNI;
                                                                                                                           and
                                                                                                                           (iii)
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           at
                                                                                                                           any
                                                                                                                           time
                                                                                                                           acquire
                                                                                                                           any
                                                                                                                           rights
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           by
                                                                                                                           virtue
                                                                                                                           of
                                                                                                                           any
                                                                                                                           use
                                                                                                                           it
                                                                                                                           may
                                                                                                                           make
                                                                                                                           thereof.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           represent,
                                                                                                                           use
                                                                                                                           or
                                                                                                                           permit
                                                                                                                           the
                                                                                                                           use
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           in
                                                                                                                           such
                                                                                                                           a way
                                                                                                                           so
                                                                                                                           as
                                                                                                                           to
                                                                                                                           give
                                                                                                                           the
                                                                                                                           impression
                                                                                                                           that
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           is
                                                                                                                           the
                                                                                                                           property
                                                                                                                           of
                                                                                                                           Neurotrope.

 

		5.2	Improvements.
                                                                                                                           All
                                                                                                                           Improvements
                                                                                                                           to
                                                                                                                           any
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           authored,
                                                                                                                           conceived,
                                                                                                                           created,
                                                                                                                           developed,
                                                                                                                           discovered,
                                                                                                                           invented
                                                                                                                           or
                                                                                                                           reduced
                                                                                                                           to
                                                                                                                           practice
                                                                                                                           by
                                                                                                                           any
                                                                                                                           Party
                                                                                                                           (whether
                                                                                                                           solely
                                                                                                                           or
                                                                                                                           jointly
                                                                                                                           with
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Person)
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           owned
                                                                                                                           solely
                                                                                                                           and
                                                                                                                           exclusively
                                                                                                                           by
                                                                                                                           BRNI.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           promptly
                                                                                                                           disclose
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           (but
                                                                                                                           in
                                                                                                                           any
                                                                                                                           event
                                                                                                                           no
                                                                                                                           more
                                                                                                                           than
                                                                                                                           thirty
                                                                                                                           (30)
                                                                                                                           days
                                                                                                                           thereafter),
                                                                                                                           and
                                                                                                                           hereby
                                                                                                                           irrevocably
                                                                                                                           assigns
                                                                                                                           and
                                                                                                                           transfer
                                                                                                                           to
                                                                                                                           BRNI,
                                                                                                                           all
                                                                                                                           Improvements
                                                                                                                           to
                                                                                                                           any
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           authored,
                                                                                                                           conceived,
                                                                                                                           created,
                                                                                                                           developed,
                                                                                                                           discovered,
                                                                                                                           invented
                                                                                                                           or
                                                                                                                           reduced
                                                                                                                           to
                                                                                                                           practice
                                                                                                                           by
                                                                                                                           Neurotrope
                                                                                                                           (whether
                                                                                                                           solely
                                                                                                                           or
                                                                                                                           jointly
                                                                                                                           with
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Person),
                                                                                                                           including
                                                                                                                           all
                                                                                                                           Intellectual
                                                                                                                           Property
                                                                                                                           therein.
                                                                                                                           Improvements
                                                                                                                           to
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           authored,
                                                                                                                           conceived,
                                                                                                                           created,
                                                                                                                           developed,
                                                                                                                           discovered,
                                                                                                                           invented
                                                                                                                           or
                                                                                                                           reduced
                                                                                                                           to
                                                                                                                           practice
                                                                                                                           by
                                                                                                                           any
                                                                                                                           Party
                                                                                                                           (whether
                                                                                                                           solely
                                                                                                                           or
                                                                                                                           jointly
                                                                                                                           with
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Person)
                                                                                                                           that
                                                                                                                           are
                                                                                                                           inside
                                                                                                                           the
                                                                                                                           Field
                                                                                                                           of
                                                                                                                           Use
                                                                                                                           shall
                                                                                                                           be:
                                                                                                                           (i) deemed
                                                                                                                           to
                                                                                                                           be
                                                                                                                           Licensed
                                                                                                                           Patents
                                                                                                                           or
                                                                                                                           Licensed
                                                                                                                           Technology,
                                                                                                                           as
                                                                                                                           applicable,
                                                                                                                           and
                                                                                                                           licensed
                                                                                                                           by
                                                                                                                           BRNI
                                                                                                                           or
                                                                                                                           sublicensed
                                                                                                                           by
                                                                                                                           NRV
                                                                                                                           II,
                                                                                                                           as
                                                                                                                           applicable,
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           Section 2.1;
                                                                                                                           and
                                                                                                                           (ii) subject
                                                                                                                           to
                                                                                                                           the
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement.
                                                                                                                           All
                                                                                                                           other
                                                                                                                           Improvements
                                                                                                                           authored,
                                                                                                                           conceived,
                                                                                                                           created,
                                                                                                                           developed,
                                                                                                                           discovered,
                                                                                                                           invented
                                                                                                                           or
                                                                                                                           reduced
                                                                                                                           to
                                                                                                                           practice
                                                                                                                           by
                                                                                                                           any
                                                                                                                           Party
                                                                                                                           (whether
                                                                                                                           solely
                                                                                                                           or
                                                                                                                           jointly
                                                                                                                           with
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Person)
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           be
                                                                                                                           included
                                                                                                                           in
                                                                                                                           any
                                                                                                                           of
                                                                                                                           the
                                                                                                                           rights
                                                                                                                           granted
                                                                                                                           under
                                                                                                                           Article
                                                                                                                           2.

 

    	 

    	 

    

 

		5.3	BRNI
                                                                                                                           Data.
                                                                                                                           BRNI
                                                                                                                           shall
                                                                                                                           solely
                                                                                                                           and
                                                                                                                           exclusively
                                                                                                                           own
                                                                                                                           all
                                                                                                                           right,
                                                                                                                           title
                                                                                                                           and
                                                                                                                           interest
                                                                                                                           in
                                                                                                                           and
                                                                                                                           to
                                                                                                                           all
                                                                                                                           BRNI
                                                                                                                           Data.
                                                                                                                           Neurotrope
                                                                                                                           hereby
                                                                                                                           irrevocably
                                                                                                                           assigns
                                                                                                                           and
                                                                                                                           transfers
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           all
                                                                                                                           right,
                                                                                                                           title
                                                                                                                           and
                                                                                                                           interest
                                                                                                                           in
                                                                                                                           and
                                                                                                                           to
                                                                                                                           the
                                                                                                                           BRNI
                                                                                                                           Data.

 

		5.4	No
                                                                                                                           Adverse
                                                                                                                           Actions.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           not,
                                                                                                                           and
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           permit
                                                                                                                           another
                                                                                                                           Person
                                                                                                                           to:
                                                                                                                           (i) challenge
                                                                                                                           BRNI’s
                                                                                                                           ownership
                                                                                                                           of,
                                                                                                                           or
                                                                                                                           BRNI’s
                                                                                                                           or
                                                                                                                           NRV
                                                                                                                           II’s
                                                                                                                           right
                                                                                                                           to
                                                                                                                           license,
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP;
                                                                                                                           (ii)
                                                                                                                           apply
                                                                                                                           for
                                                                                                                           or
                                                                                                                           seek
                                                                                                                           to
                                                                                                                           patent
                                                                                                                           or
                                                                                                                           register
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP;
                                                                                                                           (iii)
                                                                                                                           file
                                                                                                                           any
                                                                                                                           document
                                                                                                                           with
                                                                                                                           any
                                                                                                                           Governmental
                                                                                                                           Authority
                                                                                                                           or
                                                                                                                           take
                                                                                                                           any
                                                                                                                           other
                                                                                                                           action
                                                                                                                           that
                                                                                                                           would
                                                                                                                           reasonably
                                                                                                                           be
                                                                                                                           expected
                                                                                                                           to
                                                                                                                           affect
                                                                                                                           BRNI’s
                                                                                                                           ownership
                                                                                                                           of
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP;
                                                                                                                           (iv)
                                                                                                                           perform
                                                                                                                           any
                                                                                                                           action
                                                                                                                           or
                                                                                                                           omission
                                                                                                                           in
                                                                                                                           derogation
                                                                                                                           of
                                                                                                                           any
                                                                                                                           of
                                                                                                                           the
                                                                                                                           rights
                                                                                                                           of
                                                                                                                           BRNI
                                                                                                                           in
                                                                                                                           or
                                                                                                                           to
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP;
                                                                                                                           (v)
                                                                                                                           use
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP,
                                                                                                                           or
                                                                                                                           seek
                                                                                                                           to
                                                                                                                           extend
                                                                                                                           the
                                                                                                                           scope
                                                                                                                           of
                                                                                                                           usage
                                                                                                                           of
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP,
                                                                                                                           outside
                                                                                                                           of
                                                                                                                           the
                                                                                                                           limitations
                                                                                                                           set
                                                                                                                           forth
                                                                                                                           in
                                                                                                                           Article
                                                                                                                           2;
                                                                                                                           (vi)
                                                                                                                           use
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           in
                                                                                                                           any
                                                                                                                           manner,
                                                                                                                           or
                                                                                                                           take
                                                                                                                           or
                                                                                                                           allow
                                                                                                                           any
                                                                                                                           action,
                                                                                                                           that
                                                                                                                           might
                                                                                                                           diminish,
                                                                                                                           dilute
                                                                                                                           or
                                                                                                                           adversely
                                                                                                                           affect
                                                                                                                           the
                                                                                                                           reputation
                                                                                                                           of
                                                                                                                           BRNI;
                                                                                                                           or
                                                                                                                           (vii)
                                                                                                                           use
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           in
                                                                                                                           any
                                                                                                                           manner
                                                                                                                           inconsistent
                                                                                                                           with
                                                                                                                           this
                                                                                                                           Agreement.

 

		5.5	CREATE
                                                                                                                           Act.
                                                                                                                           The
                                                                                                                           Parties
                                                                                                                           acknowledge
                                                                                                                           and
                                                                                                                           agree
                                                                                                                           that
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           deemed
                                                                                                                           to
                                                                                                                           be
                                                                                                                           a Joint
                                                                                                                           Research
                                                                                                                           Agreement
                                                                                                                           as
                                                                                                                           defined
                                                                                                                           by
                                                                                                                           the
                                                                                                                           CREATE
                                                                                                                           Act.

 

		5.6	Prosecution
                                                                                                                           and
                                                                                                                           Maintenance.
                                                                                                                           As
                                                                                                                           between
                                                                                                                           Neurotrope
                                                                                                                           and
                                                                                                                           BRNI,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           have
                                                                                                                           no
                                                                                                                           right,
                                                                                                                           and
                                                                                                                           BRNI
                                                                                                                           shall
                                                                                                                           have
                                                                                                                           the
                                                                                                                           sole
                                                                                                                           and
                                                                                                                           exclusive
                                                                                                                           right
                                                                                                                           (but
                                                                                                                           not
                                                                                                                           the
                                                                                                                           obligation),
                                                                                                                           to
                                                                                                                           apply
                                                                                                                           for,
                                                                                                                           file,
                                                                                                                           prosecute,
                                                                                                                           or
                                                                                                                           maintain
                                                                                                                           patents
                                                                                                                           and
                                                                                                                           applications
                                                                                                                           for
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP,
                                                                                                                           in
                                                                                                                           each
                                                                                                                           case,
                                                                                                                           in
                                                                                                                           any
                                                                                                                           jurisdiction
                                                                                                                           throughout
                                                                                                                           the
                                                                                                                           world.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           reimburse
                                                                                                                           BRNI
                                                                                                                           for
                                                                                                                           all
                                                                                                                           of
                                                                                                                           the
                                                                                                                           attorneys’
                                                                                                                           fees,
                                                                                                                           translation
                                                                                                                           costs,
                                                                                                                           filing
                                                                                                                           fees,
                                                                                                                           maintenance
                                                                                                                           fees,
                                                                                                                           and
                                                                                                                           other
                                                                                                                           costs
                                                                                                                           and
                                                                                                                           expenses
                                                                                                                           related
                                                                                                                           to
                                                                                                                           any
                                                                                                                           of
                                                                                                                           the
                                                                                                                           foregoing;
                                                                                                                           provided,
                                                                                                                           however,
                                                                                                                           that,
                                                                                                                           if
                                                                                                                           Neurotrope
                                                                                                                           provides
                                                                                                                           written
                                                                                                                           notice
                                                                                                                           to
                                                                                                                           BRNI
                                                                                                                           of
                                                                                                                           Neurotrope’s
                                                                                                                           intent
                                                                                                                           to
                                                                                                                           not
                                                                                                                           reimburse
                                                                                                                           BRNI
                                                                                                                           for
                                                                                                                           any
                                                                                                                           such
                                                                                                                           fee,
                                                                                                                           cost
                                                                                                                           or
                                                                                                                           expense
                                                                                                                           within
                                                                                                                           thirty
                                                                                                                           (30)
                                                                                                                           days
                                                                                                                           of
                                                                                                                           the
                                                                                                                           date
                                                                                                                           of
                                                                                                                           the
                                                                                                                           applicable
                                                                                                                           invoice
                                                                                                                           therefor,
                                                                                                                           (i)
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           be
                                                                                                                           obligated
                                                                                                                           to
                                                                                                                           so
                                                                                                                           reimburse
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           that
                                                                                                                           is
                                                                                                                           the
                                                                                                                           subject
                                                                                                                           of
                                                                                                                           such
                                                                                                                           fee,
                                                                                                                           cost
                                                                                                                           or
                                                                                                                           expense
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           deemed
                                                                                                                           to
                                                                                                                           not
                                                                                                                           be
                                                                                                                           Licensed
                                                                                                                           Technology
                                                                                                                           or
                                                                                                                           Licensed
                                                                                                                           Patents,
                                                                                                                           as
                                                                                                                           applicable,
                                                                                                                           as
                                                                                                                           of
                                                                                                                           the
                                                                                                                           date
                                                                                                                           of
                                                                                                                           such
                                                                                                                           notice
                                                                                                                           (and
                                                                                                                           thereafter
                                                                                                                           not
                                                                                                                           licensed
                                                                                                                           or
                                                                                                                           sublicensed
                                                                                                                           to
                                                                                                                           Neurotrope
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           this
                                                                                                                           Agreement).
                                                                                                                           Upon
                                                                                                                           BRNI’s
                                                                                                                           request,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           cooperate
                                                                                                                           fully
                                                                                                                           with
                                                                                                                           BRNI
                                                                                                                           (including
                                                                                                                           executing
                                                                                                                           and
                                                                                                                           delivering
                                                                                                                           all
                                                                                                                           documents,
                                                                                                                           providing
                                                                                                                           all
                                                                                                                           information,
                                                                                                                           and
                                                                                                                           taking
                                                                                                                           all
                                                                                                                           such
                                                                                                                           action
                                                                                                                           as
                                                                                                                           may
                                                                                                                           be
                                                                                                                           necessary
                                                                                                                           or
                                                                                                                           appropriate)
                                                                                                                           in
                                                                                                                           preparing,
                                                                                                                           executing,
                                                                                                                           filing
                                                                                                                           and
                                                                                                                           prosecuting
                                                                                                                           applications
                                                                                                                           to
                                                                                                                           patent
                                                                                                                           or
                                                                                                                           register
                                                                                                                           any
                                                                                                                           Licensed
                                                                                                                           IP,
                                                                                                                           and
                                                                                                                           applications
                                                                                                                           for
                                                                                                                           other
                                                                                                                           related
                                                                                                                           patents
                                                                                                                           and
                                                                                                                           registrations
                                                                                                                           and
                                                                                                                           in
                                                                                                                           maintaining
                                                                                                                           all
                                                                                                                           such
                                                                                                                           patents
                                                                                                                           and
                                                                                                                           registrations
                                                                                                                           as
                                                                                                                           may
                                                                                                                           issue.

 

		5.7	Enforcement.

 

		5.7.1	Notice. Neurotrope shall immediately notify BRNI in writing of any actual or suspected Infringement
or any challenge to the validity, enforceability or scope of the Licensed IP, inside the Field of Use, of which Neurotrope may
become aware. Such notice shall, to the extent Neurotrope is aware of such information: (i) identify the alleged Person involved
in the Infringement; (ii) detail the specific aspects of the Licensed IP that are the subject of such Infringement (including any
specific patent claims) and the particular manner of such Infringement (including any particular products); (iii) identify
the geographic area in which such Infringement is occurring; (iv) provide a good faith estimate of the lost sales or other Losses
to Neurotrope due to such Infringement; and (v) be updated, corrected or supplemented by Neurotrope promptly after Neurotrope
becomes aware of any information that tends to either substantiate or call into question the claim of Infringement.

 

    	 

    	 

    

 

		5.7.2	Enforcement and Defense of the Licensed IP.

 

		5.7.2.1	By Neurotrope. As between Neurotrope, on the one hand, and BRNI and NRV II, on the other
hand, subject to Section 5.7.3 and Section 5.7.4, BRNI and NRV II shall have no right, and Neurotrope shall have
the sole and exclusive right (but not the obligation) to, at Neurotrope’s sole cost and expense, inside the Field of Use,
enforce the Licensed IP and defend the validity, enforceability or scope of the Licensed IP. Upon Neurotrope’s request, BRNI
and NRV II shall cooperate fully with Neurotrope, as applicable (including executing and delivering all documents, providing all
information, and taking all such action as may be necessary or appropriate) in, inside the Field of Use, enforcing the Licensed
IP and defending the validity, enforceability or scope of the Licensed IP, including joining as a party to any suit, testifying
at any proceeding, and executing any instruments or documents.

 

		5.7.2.2	By BRNI and NRV II. As between Neurotrope, on the one hand, and BRNI and NRV II, on the
other hand, Neurotrope shall have no right, and BRNI and NRV II shall have the sole and exclusive right (but not the obligation)
to, at BRNI and NRV II’s sole cost and expense, enforce the Licensed IP and defend the validity, enforceability or scope
of the Licensed IP, (i) outside the Field of Use and (ii) subject to Section 5.7.3, inside the Field of Use. Upon BRNI’s
or NRV II’s request, Neurotrope shall cooperate fully with BRNI or NRV II, as applicable (including executing and delivering
all documents, providing all information, and taking all such action as may be necessary or appropriate) in enforcing the Licensed
IP and defending the validity, enforceability or scope of the Licensed IP, including joining as a party to any suit, testifying
at any proceeding, and executing any instruments or documents.

 

		5.7.3	Enforcement by BRNI Inside the Field of Use. If, within sixty (60) days after Neurotrope’s
receipt or delivery (as the case may be) of a notice described in Section 5.7.1, Neurotrope has not, in accordance
with Section 5.7.2.1 and Section 5.7.4, as applicable, (i) brought an action to enforce the Licensed IP inside the
Field of Use, (ii) defended the validity, enforceability or scope of the Licensed IP, and/or (iii) otherwise terminated
the actual or suspected Infringement, inside the Field of Use, then Neurotrope shall have no right, and BRNI and NRV II shall have
the sole and exclusive right (but not the obligation) to, with respect to the matters referenced in such notice, enforce the Licensed
IP and defend the validity, enforceability or scope of the Licensed IP.

 

    	 

    	 

    

 

		5.7.4	Conditions of Enforcement by Neurotrope. Neurotrope shall comply with the following with
respect to any enforcement or defense in connection with Section 5.7.2.1: (i) Neurotrope shall first give BRNI written
notice of Neurotrope’s intent to bring or participate in any action to enforce, or defense of, the Licensed IP inside the
Field of Use a reasonable period of time in advance of commencing any such action or engaging in such defense; and (ii) Neurotrope
may not undertake any such action or defense without BRNI’s prior written consent (not to be unreasonably withheld). In the
event BRNI grants such consent: (a) Neurotrope shall consult with BRNI, keep BRNI reasonably informed with respect to such action
or defense, and consider, in good faith, any advice of BRNI with respect to such action or defense; (b) Neurotrope may not, without
BRNI’s prior written consent, settle, compromise or consent to the entry of any judgment in any such action or defense, unless
such settlement, compromise or consent (I) includes an unconditional release of the BRNI, its Affiliates (other than Neurotrope)
and its and their respective directors, officers, employees and agents from all liability arising out of such action or defense
and (II) is solely monetary in nature and does not include a statement as to, or an admission of fault, culpability or failure
to act by or on behalf of, the BRNI, its Affiliates (other than Neurotrope) and its and their respective directors, officers, employees
and agents; and (c) Neurotrope shall reimburse BRNI for all costs and expenses incurred by BRNI or its Affiliates (other than Neurotrope)
in connection with such action or defense (including joining as a as a party to any suit and testifying at any proceeding). Neurotrope
may retain all recovery and income (including damages, licensing fees, royalties, settlement payments and other payments) received
as a result of any action or defense in which it engages pursuant to Section 5.7.2.1.

 

		6.	Additional Neurotrope Obligations

 

		6.1	Diligence.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           use
                                                                                                                           its
                                                                                                                           best
                                                                                                                           efforts,
                                                                                                                           throughout
                                                                                                                           the
                                                                                                                           world,
                                                                                                                           (i)
                                                                                                                           to
                                                                                                                           develop,
                                                                                                                           use,
                                                                                                                           manufacture,
                                                                                                                           market,
                                                                                                                           offer
                                                                                                                           for
                                                                                                                           sale,
                                                                                                                           sell,
                                                                                                                           distribute,
                                                                                                                           import
                                                                                                                           and
                                                                                                                           export
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Field
                                                                                                                           of
                                                                                                                           Use,
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           to
                                                                                                                           sublicense
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           IP
                                                                                                                           to
                                                                                                                           Third
                                                                                                                           Parties
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Field
                                                                                                                           of
                                                                                                                           Use
                                                                                                                           under
                                                                                                                           reasonable
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           (including
                                                                                                                           reasonable
                                                                                                                           amounts
                                                                                                                           of
                                                                                                                           up-front
                                                                                                                           fees,
                                                                                                                           royalties,
                                                                                                                           licensing
                                                                                                                           or
                                                                                                                           sublicensing
                                                                                                                           fees,
                                                                                                                           milestone
                                                                                                                           payments,
                                                                                                                           lump
                                                                                                                           sum
                                                                                                                           payments
                                                                                                                           or
                                                                                                                           other
                                                                                                                           payments).

 

		6.2	Compliance
                                                                                                                                  with
                                                                                                                                  Law.
                                                                                                                                  Neurotrope
                                                                                                                                  shall
                                                                                                                                  develop,
                                                                                                                                  use,
                                                                                                                                  manufacture,
                                                                                                                                  market,
                                                                                                                                  offer
                                                                                                                                  for
                                                                                                                                  sale,
                                                                                                                                  sell,
                                                                                                                                  distribute,
                                                                                                                                  import
                                                                                                                                  and
                                                                                                                                  export
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  Products
                                                                                                                                  in
                                                                                                                                  strict
                                                                                                                                  compliance
                                                                                                                                  with
                                                                                                                                  all
                                                                                                                                  Laws.
                                                                                                                                  Neurotrope
                                                                                                                                  shall
                                                                                                                                  keep
                                                                                                                                  BRNI
                                                                                                                                  fully
                                                                                                                                  informed
                                                                                                                                  of,
                                                                                                                                  and
                                                                                                                                  shall
                                                                                                                                  move
                                                                                                                                  expeditiously
                                                                                                                                  to
                                                                                                                                  resolve,
                                                                                                                                  any
                                                                                                                                  Action
                                                                                                                                  by
                                                                                                                                  a
                                                                                                                                  Governmental
                                                                                                                                  Authority
                                                                                                                                  related
                                                                                                                                  to
                                                                                                                                  any
                                                                                                                                  Licensed
                                                                                                                                  Product.

 

		6.3	Marking.
                                                                                                                                  Neurotrope
                                                                                                                                  shall
                                                                                                                                  mark
                                                                                                                                  all
                                                                                                                                  Licensed
                                                                                                                                  Products
                                                                                                                                  with,
                                                                                                                                  and
                                                                                                                                  include
                                                                                                                                  in
                                                                                                                                  all
                                                                                                                                  related
                                                                                                                                  sales
                                                                                                                                  and
                                                                                                                                  marketing
                                                                                                                                  literature,
                                                                                                                                  and
                                                                                                                                  other
                                                                                                                                  materials
                                                                                                                                  and
                                                                                                                                  documents:
                                                                                                                                  (i)
                                                                                                                                  any
                                                                                                                                  applicable
                                                                                                                                  United
                                                                                                                                  States
                                                                                                                                  of
                                                                                                                                  America
                                                                                                                                  and
                                                                                                                                  foreign
                                                                                                                                  patent
                                                                                                                                  numbers
                                                                                                                                  in
                                                                                                                                  accordance
                                                                                                                                  with
                                                                                                                                  the
                                                                                                                                  applicable
                                                                                                                                  Laws
                                                                                                                                  of
                                                                                                                                  the
                                                                                                                                  countries
                                                                                                                                  in
                                                                                                                                  which
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  Products
                                                                                                                                  are
                                                                                                                                  intended
                                                                                                                                  to
                                                                                                                                  be
                                                                                                                                  used,
                                                                                                                                  manufactured,
                                                                                                                                  marketed,
                                                                                                                                  offered
                                                                                                                                  for
                                                                                                                                  sale,
                                                                                                                                  sold,
                                                                                                                                  distributed,
                                                                                                                                  imported
                                                                                                                                  or
                                                                                                                                  exported,
                                                                                                                                  as
                                                                                                                                  may
                                                                                                                                  be
                                                                                                                                  directed
                                                                                                                                  by
                                                                                                                                  BRNI;
                                                                                                                                  (ii)
                                                                                                                                  any
                                                                                                                                  other
                                                                                                                                  legends
                                                                                                                                  as
                                                                                                                                  may
                                                                                                                                  be
                                                                                                                                  reasonably
                                                                                                                                  requested
                                                                                                                                  by
                                                                                                                                  BRNI
                                                                                                                                  to
                                                                                                                                  ensure
                                                                                                                                  that
                                                                                                                                  BRNI’s
                                                                                                                                  rights
                                                                                                                                  under
                                                                                                                                  and
                                                                                                                                  to
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  IP
                                                                                                                                  are
                                                                                                                                  fully
                                                                                                                                  protected;
                                                                                                                                  and
                                                                                                                                  (iii)
                                                                                                                                  any
                                                                                                                                  other
                                                                                                                                  marking
                                                                                                                                  as
                                                                                                                                  may
                                                                                                                                  be
                                                                                                                                  required
                                                                                                                                  in
                                                                                                                                  accordance
                                                                                                                                  with
                                                                                                                                  applicable
                                                                                                                                  Laws.

 

    	 

    	 

    

 

		6.4	Regulatory
                                                                                                                           Approval.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           responsible
                                                                                                                           for
                                                                                                                           filing,
                                                                                                                           obtaining
                                                                                                                           and
                                                                                                                           maintaining
                                                                                                                           all
                                                                                                                           licenses
                                                                                                                           and
                                                                                                                           approvals
                                                                                                                           (including
                                                                                                                           FDA
                                                                                                                           approvals)
                                                                                                                           necessary
                                                                                                                           for
                                                                                                                           the
                                                                                                                           development,
                                                                                                                           use,
                                                                                                                           making,
                                                                                                                           marketing,
                                                                                                                           offer
                                                                                                                           for
                                                                                                                           sale,
                                                                                                                           sale,
                                                                                                                           distribution,
                                                                                                                           importation
                                                                                                                           and
                                                                                                                           exportation
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products,
                                                                                                                           together
                                                                                                                           with
                                                                                                                           all
                                                                                                                           related
                                                                                                                           costs
                                                                                                                           and
                                                                                                                           expenses.
                                                                                                                           All
                                                                                                                           such
                                                                                                                           licenses
                                                                                                                           and
                                                                                                                           approvals,
                                                                                                                           and
                                                                                                                           filings
                                                                                                                           and
                                                                                                                           applications
                                                                                                                           therefor,
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           held
                                                                                                                           in
                                                                                                                           the
                                                                                                                           name
                                                                                                                           of
                                                                                                                           Neurotrope
                                                                                                                           (or
                                                                                                                           its
                                                                                                                           designated
                                                                                                                           Affiliate).
                                                                                                                           BRNI
                                                                                                                           shall
                                                                                                                           provide
                                                                                                                           Neurotrope
                                                                                                                           with
                                                                                                                           support
                                                                                                                           for
                                                                                                                           filing,
                                                                                                                           obtaining
                                                                                                                           and
                                                                                                                           maintaining
                                                                                                                           all
                                                                                                                           such
                                                                                                                           licenses
                                                                                                                           and
                                                                                                                           approvals
                                                                                                                           (including
                                                                                                                           pre-clinical
                                                                                                                           or
                                                                                                                           clinical
                                                                                                                           activities
                                                                                                                           or
                                                                                                                           trials)
                                                                                                                           as
                                                                                                                           part
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Services
                                                                                                                           in
                                                                                                                           accordance
                                                                                                                           with
                                                                                                                           the
                                                                                                                           applicable
                                                                                                                           SOW.
                                                                                                                           Unless
                                                                                                                           otherwise
                                                                                                                           limited
                                                                                                                           or
                                                                                                                           prohibited
                                                                                                                           by
                                                                                                                           applicable
                                                                                                                           Law,
                                                                                                                           to
                                                                                                                           the
                                                                                                                           extent
                                                                                                                           reasonably
                                                                                                                           practicable
                                                                                                                           under
                                                                                                                           the
                                                                                                                           circumstances,
                                                                                                                           Neurotrope
                                                                                                                           shall:
                                                                                                                           (i)
                                                                                                                           promptly
                                                                                                                           provide
                                                                                                                           BRNI
                                                                                                                           with
                                                                                                                           copies
                                                                                                                           of
                                                                                                                           any
                                                                                                                           material
                                                                                                                           written
                                                                                                                           communication
                                                                                                                           to
                                                                                                                           or
                                                                                                                           from,
                                                                                                                           and
                                                                                                                           a summary
                                                                                                                           of
                                                                                                                           any
                                                                                                                           material
                                                                                                                           oral
                                                                                                                           communication
                                                                                                                           with,
                                                                                                                           any
                                                                                                                           Governmental
                                                                                                                           Authority
                                                                                                                           relating
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products;
                                                                                                                           (ii)
                                                                                                                           allow
                                                                                                                           BRNI
                                                                                                                           a reasonable
                                                                                                                           opportunity
                                                                                                                           to
                                                                                                                           review
                                                                                                                           and
                                                                                                                           comment
                                                                                                                           on
                                                                                                                           any
                                                                                                                           material
                                                                                                                           submission
                                                                                                                           or
                                                                                                                           material
                                                                                                                           correspondence
                                                                                                                           to
                                                                                                                           any
                                                                                                                           Governmental
                                                                                                                           Authority
                                                                                                                           relating
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products;
                                                                                                                           (iii)
                                                                                                                           consider
                                                                                                                           in
                                                                                                                           good
                                                                                                                           faith
                                                                                                                           any
                                                                                                                           comments
                                                                                                                           made
                                                                                                                           by
                                                                                                                           BRNI
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           clause
                                                                                                                           (ii)
                                                                                                                           or
                                                                                                                           otherwise
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           material
                                                                                                                           interactions
                                                                                                                           with
                                                                                                                           any
                                                                                                                           Governmental
                                                                                                                           Authority
                                                                                                                           concerning
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products;
                                                                                                                           (iv) afford
                                                                                                                           BRNI
                                                                                                                           the
                                                                                                                           opportunity
                                                                                                                           to
                                                                                                                           attend
                                                                                                                           any
                                                                                                                           in-person
                                                                                                                           material
                                                                                                                           meetings,
                                                                                                                           and
                                                                                                                           listen
                                                                                                                           in
                                                                                                                           on,
                                                                                                                           or
                                                                                                                           participate
                                                                                                                           in,
                                                                                                                           any
                                                                                                                           planned
                                                                                                                           material
                                                                                                                           calls,
                                                                                                                           with
                                                                                                                           any
                                                                                                                           Governmental
                                                                                                                           Authority
                                                                                                                           relating
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products;
                                                                                                                           and
                                                                                                                           (v)
                                                                                                                           otherwise
                                                                                                                           provide
                                                                                                                           BRNI
                                                                                                                           with
                                                                                                                           any
                                                                                                                           reasonably
                                                                                                                           requested
                                                                                                                           information
                                                                                                                           and
                                                                                                                           documentation
                                                                                                                           relating
                                                                                                                           to
                                                                                                                           material
                                                                                                                           regulatory
                                                                                                                           submissions
                                                                                                                           or
                                                                                                                           approvals.
                                                                                                                           For
                                                                                                                           purposes
                                                                                                                           of
                                                                                                                           the
                                                                                                                           foregoing
                                                                                                                           sentence,
                                                                                                                           the
                                                                                                                           term
                                                                                                                           “material”
                                                                                                                           (as
                                                                                                                           used
                                                                                                                           in
                                                                                                                           reference
                                                                                                                           to
                                                                                                                           certain
                                                                                                                           communications,
                                                                                                                           correspondence,
                                                                                                                           meetings,
                                                                                                                           submissions,
                                                                                                                           approvals,
                                                                                                                           and
                                                                                                                           interactions)
                                                                                                                           shall
                                                                                                                           mean
                                                                                                                           and
                                                                                                                           include
                                                                                                                           those
                                                                                                                           correspondence,
                                                                                                                           meetings,
                                                                                                                           submissions,
                                                                                                                           approvals,
                                                                                                                           and
                                                                                                                           interactions
                                                                                                                           between
                                                                                                                           Neurotrope
                                                                                                                           and
                                                                                                                           a Governmental
                                                                                                                           Authority
                                                                                                                           that
                                                                                                                           one
                                                                                                                           would
                                                                                                                           reasonably
                                                                                                                           anticipate
                                                                                                                           having
                                                                                                                           a material
                                                                                                                           impact
                                                                                                                           on
                                                                                                                           the
                                                                                                                           grant
                                                                                                                           or
                                                                                                                           maintenance
                                                                                                                           of
                                                                                                                           a regulatory
                                                                                                                           approval
                                                                                                                           necessary
                                                                                                                           to
                                                                                                                           develop,
                                                                                                                           use,
                                                                                                                           manufacture,
                                                                                                                           market,
                                                                                                                           offer
                                                                                                                           for
                                                                                                                           sale,
                                                                                                                           sell,
                                                                                                                           distribute,
                                                                                                                           import
                                                                                                                           and
                                                                                                                           export
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products.

 

		6.5	Export
                                                                                                                           Compliance.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           comply
                                                                                                                           with
                                                                                                                           all
                                                                                                                           applicable
                                                                                                                           Laws
                                                                                                                           that
                                                                                                                           may
                                                                                                                           prohibit
                                                                                                                           or
                                                                                                                           limit
                                                                                                                           the
                                                                                                                           import,
                                                                                                                           export,
                                                                                                                           release
                                                                                                                           or
                                                                                                                           disclosure
                                                                                                                           of
                                                                                                                           any
                                                                                                                           information,
                                                                                                                           technology,
                                                                                                                           materials
                                                                                                                           or
                                                                                                                           products
                                                                                                                           to
                                                                                                                           any
                                                                                                                           Person
                                                                                                                           inside
                                                                                                                           or
                                                                                                                           outside
                                                                                                                           any
                                                                                                                           country,
                                                                                                                           including
                                                                                                                           the
                                                                                                                           U.S.
                                                                                                                           International
                                                                                                                           Traffic
                                                                                                                           in
                                                                                                                           Arms
                                                                                                                           Regulations,
                                                                                                                           the
                                                                                                                           U.S.
                                                                                                                           Export
                                                                                                                           Administration
                                                                                                                           Regulations
                                                                                                                           and
                                                                                                                           the
                                                                                                                           Office
                                                                                                                           of
                                                                                                                           Foreign
                                                                                                                           Assets
                                                                                                                           Control
                                                                                                                           Regulations.

 

		6.6	Additional
                                                                                                                                  Reporting.
                                                                                                                                  Together
                                                                                                                                  with
                                                                                                                                  the
                                                                                                                                  report
                                                                                                                                  provided
                                                                                                                                  by
                                                                                                                                  Neurotrope
                                                                                                                                  pursuant
                                                                                                                                  to
                                                                                                                                  Section
                                                                                                                                  4.5,
                                                                                                                                  or
                                                                                                                                  otherwise
                                                                                                                                  upon
                                                                                                                                  BRNI’s
                                                                                                                                  request,
                                                                                                                                  Neurotrope
                                                                                                                                  shall
                                                                                                                                  provide
                                                                                                                                  to
                                                                                                                                  BRNI
                                                                                                                                  a
                                                                                                                                  report
                                                                                                                                  providing:
                                                                                                                                  (i)
                                                                                                                                  data,
                                                                                                                                  documentation
                                                                                                                                  and
                                                                                                                                  information
                                                                                                                                  regarding
                                                                                                                                  any
                                                                                                                                  adverse
                                                                                                                                  consequences
                                                                                                                                  of
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  IP
                                                                                                                                  of
                                                                                                                                  which
                                                                                                                                  Neurotrope
                                                                                                                                  or
                                                                                                                                  any
                                                                                                                                  of
                                                                                                                                  its
                                                                                                                                  sublicensees
                                                                                                                                  is
                                                                                                                                  aware;
                                                                                                                                  (ii)
                                                                                                                                  data,
                                                                                                                                  documentation
                                                                                                                                  and
                                                                                                                                  information
                                                                                                                                  regarding
                                                                                                                                  the
                                                                                                                                  usage
                                                                                                                                  of
                                                                                                                                  Licensed
                                                                                                                                  IP
                                                                                                                                  by
                                                                                                                                  Neurotrope,
                                                                                                                                  its
                                                                                                                                  sublicensees
                                                                                                                                  and
                                                                                                                                  its
                                                                                                                                  and
                                                                                                                                  their
                                                                                                                                  customers
                                                                                                                                  and
                                                                                                                                  end-users
                                                                                                                                  (including
                                                                                                                                  for
                                                                                                                                  what
                                                                                                                                  indications
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  IP
                                                                                                                                  is
                                                                                                                                  used);
                                                                                                                                  (iii)
                                                                                                                                  data,
                                                                                                                                  documentation
                                                                                                                                  and
                                                                                                                                  information
                                                                                                                                  regarding
                                                                                                                                  any
                                                                                                                                  compounds
                                                                                                                                  utilized
                                                                                                                                  in
                                                                                                                                  connection
                                                                                                                                  with
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  IP;
                                                                                                                                  and
                                                                                                                                  (iv)
                                                                                                                                  any
                                                                                                                                  other
                                                                                                                                  data,
                                                                                                                                  documentation
                                                                                                                                  or
                                                                                                                                  information
                                                                                                                                  related
                                                                                                                                  to
                                                                                                                                  clauses
                                                                                                                                  (i)
                                                                                                                                  through
                                                                                                                                  (iii)
                                                                                                                                  as
                                                                                                                                  reasonably
                                                                                                                                  requested
                                                                                                                                  by
                                                                                                                                  BRNI.

 

    	 

    	 

    

 

		7.	Confidentiality

 

		7.1	Duty
                                                                                                                           of
                                                                                                                           Confidentiality.
                                                                                                                           Each
                                                                                                                           Party
                                                                                                                           shall
                                                                                                                           keep
                                                                                                                           strictly
                                                                                                                           confidential,
                                                                                                                           and
                                                                                                                           shall
                                                                                                                           not
                                                                                                                           publish
                                                                                                                           or
                                                                                                                           otherwise
                                                                                                                           disclose
                                                                                                                           or
                                                                                                                           use
                                                                                                                           for
                                                                                                                           any
                                                                                                                           purpose
                                                                                                                           other
                                                                                                                           than
                                                                                                                           as
                                                                                                                           expressly
                                                                                                                           provided
                                                                                                                           for
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           any
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Party.
                                                                                                                           Without
                                                                                                                           limiting
                                                                                                                           the
                                                                                                                           foregoing,
                                                                                                                           each
                                                                                                                           Party
                                                                                                                           shall
                                                                                                                           exercise
                                                                                                                           the
                                                                                                                           highest
                                                                                                                           degree
                                                                                                                           of
                                                                                                                           care
                                                                                                                           to
                                                                                                                           protect
                                                                                                                           the
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Party
                                                                                                                           as
                                                                                                                           it
                                                                                                                           exercises
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           its
                                                                                                                           own
                                                                                                                           highly
                                                                                                                           sensitive
                                                                                                                           confidential
                                                                                                                           information,
                                                                                                                           but
                                                                                                                           in
                                                                                                                           no
                                                                                                                           case
                                                                                                                           less
                                                                                                                           than
                                                                                                                           a reasonable
                                                                                                                           degree
                                                                                                                           of
                                                                                                                           care.
                                                                                                                           Each
                                                                                                                           Party,
                                                                                                                           as
                                                                                                                           a Receiving
                                                                                                                           Party,
                                                                                                                           shall
                                                                                                                           limit
                                                                                                                           access
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Disclosing
                                                                                                                           Party
                                                                                                                           to
                                                                                                                           only
                                                                                                                           its
                                                                                                                           Affiliates,
                                                                                                                           and
                                                                                                                           its
                                                                                                                           and
                                                                                                                           their
                                                                                                                           directors,
                                                                                                                           officers,
                                                                                                                           employees,
                                                                                                                           agents,
                                                                                                                           consultants
                                                                                                                           and
                                                                                                                           contractors
                                                                                                                           with
                                                                                                                           a “need-to-know”
                                                                                                                           in
                                                                                                                           order
                                                                                                                           to
                                                                                                                           perform
                                                                                                                           his
                                                                                                                           or
                                                                                                                           her
                                                                                                                           duties
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           or
                                                                                                                           to
                                                                                                                           provide
                                                                                                                           or
                                                                                                                           receive
                                                                                                                           the
                                                                                                                           Services,
                                                                                                                           as
                                                                                                                           applicable.
                                                                                                                           Each
                                                                                                                           Party
                                                                                                                           shall
                                                                                                                           ensure
                                                                                                                           that
                                                                                                                           all
                                                                                                                           of
                                                                                                                           its
                                                                                                                           Affiliates,
                                                                                                                           and
                                                                                                                           its
                                                                                                                           and
                                                                                                                           their
                                                                                                                           directors,
                                                                                                                           officers,
                                                                                                                           employees,
                                                                                                                           agents,
                                                                                                                           consultants
                                                                                                                           and
                                                                                                                           contractors
                                                                                                                           who
                                                                                                                           may
                                                                                                                           be
                                                                                                                           exposed
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           any
                                                                                                                           other
                                                                                                                           Party
                                                                                                                           shall
                                                                                                                           comply
                                                                                                                           with
                                                                                                                           such
                                                                                                                           Party’s
                                                                                                                           obligations
                                                                                                                           as
                                                                                                                           set
                                                                                                                           forth
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           7.
                                                                                                                           Each
                                                                                                                           Party
                                                                                                                           may
                                                                                                                           disclose
                                                                                                                           the
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           to
                                                                                                                           its
                                                                                                                           Affiliates,
                                                                                                                           and
                                                                                                                           its
                                                                                                                           and
                                                                                                                           their
                                                                                                                           directors,
                                                                                                                           officers,
                                                                                                                           employees,
                                                                                                                           agents,
                                                                                                                           attorneys,
                                                                                                                           accountants,
                                                                                                                           other
                                                                                                                           advisors,
                                                                                                                           and
                                                                                                                           actual
                                                                                                                           or
                                                                                                                           potential
                                                                                                                           investors
                                                                                                                           or
                                                                                                                           sources
                                                                                                                           of
                                                                                                                           financing.
                                                                                                                           With
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           a Disclosing
                                                                                                                           Party,
                                                                                                                           the
                                                                                                                           Receiving
                                                                                                                           Party
                                                                                                                           shall
                                                                                                                           promptly
                                                                                                                           inform
                                                                                                                           the
                                                                                                                           Disclosing
                                                                                                                           Party
                                                                                                                           in
                                                                                                                           the
                                                                                                                           event
                                                                                                                           of
                                                                                                                           any
                                                                                                                           loss
                                                                                                                           or
                                                                                                                           unauthorized
                                                                                                                           disclosure
                                                                                                                           thereof
                                                                                                                           of
                                                                                                                           which
                                                                                                                           the
                                                                                                                           Receiving
                                                                                                                           Party
                                                                                                                           becomes
                                                                                                                           aware.

 

		7.2	Exclusions
                                                                                                                                  to
                                                                                                                                  Duties
                                                                                                                                  of
                                                                                                                                  Confidentiality.
                                                                                                                                  The
                                                                                                                                  foregoing
                                                                                                                                  duties
                                                                                                                                  of
                                                                                                                                  confidentiality
                                                                                                                                  set
                                                                                                                                  forth
                                                                                                                                  in
                                                                                                                                  Section
                                                                                                                                  7.1
                                                                                                                                  shall
                                                                                                                                  not
                                                                                                                                  apply
                                                                                                                                  to
                                                                                                                                  any
                                                                                                                                  particular
                                                                                                                                  Confidential
                                                                                                                                  Information
                                                                                                                                  that
                                                                                                                                  the
                                                                                                                                  Receiving
                                                                                                                                  Party
                                                                                                                                  can
                                                                                                                                  show
                                                                                                                                  by
                                                                                                                                  written
                                                                                                                                  documentation:

 

		(i)	was or has later become available to the public through no breach of this Agreement

 

		(ii)	was obtained from a Third Party lawfully in possession of such information that had the legal right
to disclose the information without it being subject to a continuing obligation of confidentiality;

 

		(iii)	was already in the Receiving Party’s possession (without an obligation of confidentiality)
prior to direct or indirect disclosure pursuant to this Agreement (or any predecessor agreement between the Parties governing the
confidentiality of such information) and was not generated in connection with, this Agreement;

 

		(iv)	was developed independently by the Receiving Party (with no reference to any information disclosed
to it by the Disclosing Party, whether before or after the Effective Date); or

 

		(v)	was disclosed only after receipt of prior written approval to disclose from a duly authorized representative
of the Disclosing Party.

 

    	 

    	 

    

 

		7.3	Permitted
                                                                                                                                  Disclosure.
                                                                                                                                  If
                                                                                                                                  the
                                                                                                                                  Receiving
                                                                                                                                  Party
                                                                                                                                  is
                                                                                                                                  requested
                                                                                                                                  or
                                                                                                                                  required
                                                                                                                                  to
                                                                                                                                  disclose
                                                                                                                                  all
                                                                                                                                  or
                                                                                                                                  any
                                                                                                                                  part
                                                                                                                                  of
                                                                                                                                  any
                                                                                                                                  Confidential
                                                                                                                                  Information
                                                                                                                                  of
                                                                                                                                  the
                                                                                                                                  Disclosing
                                                                                                                                  Party
                                                                                                                                  under
                                                                                                                                  a
                                                                                                                                  discovery
                                                                                                                                  request,
                                                                                                                                  a
                                                                                                                                  subpoena,
                                                                                                                                  or
                                                                                                                                  an
                                                                                                                                  inquiry
                                                                                                                                  issued
                                                                                                                                  by
                                                                                                                                  a
                                                                                                                                  Governmental
                                                                                                                                  Authority
                                                                                                                                  or
                                                                                                                                  under
                                                                                                                                  applicable
                                                                                                                                  Law,
                                                                                                                                  the
                                                                                                                                  Receiving
                                                                                                                                  Party
                                                                                                                                  shall,
                                                                                                                                  to
                                                                                                                                  the
                                                                                                                                  extent
                                                                                                                                  practicable
                                                                                                                                  and
                                                                                                                                  subject
                                                                                                                                  to
                                                                                                                                  applicable
                                                                                                                                  Laws,
                                                                                                                                  give
                                                                                                                                  prompt
                                                                                                                                  notice
                                                                                                                                  of
                                                                                                                                  such
                                                                                                                                  request
                                                                                                                                  to
                                                                                                                                  the
                                                                                                                                  Disclosing
                                                                                                                                  Party
                                                                                                                                  and
                                                                                                                                  shall
                                                                                                                                  give
                                                                                                                                  the
                                                                                                                                  Disclosing
                                                                                                                                  Party
                                                                                                                                  the
                                                                                                                                  opportunity
                                                                                                                                  to
                                                                                                                                  seek
                                                                                                                                  an
                                                                                                                                  appropriate
                                                                                                                                  confidentiality
                                                                                                                                  agreement,
                                                                                                                                  protective
                                                                                                                                  order
                                                                                                                                  or
                                                                                                                                  modification
                                                                                                                                  of
                                                                                                                                  any
                                                                                                                                  disclosure
                                                                                                                                  or
                                                                                                                                  otherwise
                                                                                                                                  intervene,
                                                                                                                                  prevent,
                                                                                                                                  delay
                                                                                                                                  or
                                                                                                                                  otherwise
                                                                                                                                  affect
                                                                                                                                  the
                                                                                                                                  response
                                                                                                                                  to
                                                                                                                                  such
                                                                                                                                  request,
                                                                                                                                  and
                                                                                                                                  the
                                                                                                                                  Receiving
                                                                                                                                  Party
                                                                                                                                  shall
                                                                                                                                  cooperate
                                                                                                                                  in
                                                                                                                                  such
                                                                                                                                  efforts.
                                                                                                                                  BRNI
                                                                                                                                  may
                                                                                                                                  publish
                                                                                                                                  the
                                                                                                                                  results
                                                                                                                                  of
                                                                                                                                  any
                                                                                                                                  research
                                                                                                                                  undertaken
                                                                                                                                  by
                                                                                                                                  BRNI
                                                                                                                                  pursuant
                                                                                                                                  to
                                                                                                                                  this
                                                                                                                                  Agreement
                                                                                                                                  (including
                                                                                                                                  in
                                                                                                                                  connection
                                                                                                                                  with
                                                                                                                                  any
                                                                                                                                  Services)
                                                                                                                                  within
                                                                                                                                  a
                                                                                                                                  reasonable
                                                                                                                                  period
                                                                                                                                  of
                                                                                                                                  time
                                                                                                                                  after
                                                                                                                                  completion
                                                                                                                                  of
                                                                                                                                  the
                                                                                                                                  research
                                                                                                                                  and
                                                                                                                                  a
                                                                                                                                  review
                                                                                                                                  of
                                                                                                                                  such
                                                                                                                                  proposed
                                                                                                                                  publication
                                                                                                                                  by
                                                                                                                                  Neurotrope.
                                                                                                                                  The
                                                                                                                                  Parties
                                                                                                                                  acknowledge
                                                                                                                                  and
                                                                                                                                  agree
                                                                                                                                  that
                                                                                                                                  it
                                                                                                                                  is
                                                                                                                                  the
                                                                                                                                  Parties’
                                                                                                                                  express
                                                                                                                                  intent
                                                                                                                                  that
                                                                                                                                  such
                                                                                                                                  results
                                                                                                                                  (including
                                                                                                                                  in
                                                                                                                                  the
                                                                                                                                  Field
                                                                                                                                  of
                                                                                                                                  Use)
                                                                                                                                  be
                                                                                                                                  published
                                                                                                                                  in
                                                                                                                                  accordance
                                                                                                                                  with
                                                                                                                                  principles
                                                                                                                                  set
                                                                                                                                  forth
                                                                                                                                  in
                                                                                                                                  Rev.
                                                                                                                                  Rul.
                                                                                                                                  76-296,
                                                                                                                                  1976-2
                                                                                                                                  CB
                                                                                                                                  141,
                                                                                                                                  Situation
                                                                                                                                  1.

 

		7.4	Tax-Related
                                                                                                                           Disclosure.
                                                                                                                           Notwithstanding
                                                                                                                           anything
                                                                                                                           to
                                                                                                                           the
                                                                                                                           contrary
                                                                                                                           contained
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           each
                                                                                                                           Party
                                                                                                                           may
                                                                                                                           disclose
                                                                                                                           to
                                                                                                                           any
                                                                                                                           and
                                                                                                                           all
                                                                                                                           Persons,
                                                                                                                           without
                                                                                                                           limitation
                                                                                                                           of
                                                                                                                           any
                                                                                                                           kind,
                                                                                                                           the
                                                                                                                           tax
                                                                                                                           treatment
                                                                                                                           and
                                                                                                                           the
                                                                                                                           tax
                                                                                                                           structure
                                                                                                                           (as
                                                                                                                           such
                                                                                                                           terms
                                                                                                                           are
                                                                                                                           used
                                                                                                                           in
                                                                                                                           Internal
                                                                                                                           Revenue
                                                                                                                           Code
                                                                                                                           §6011
                                                                                                                           and
                                                                                                                           the
                                                                                                                           Treasury
                                                                                                                           Regulations
                                                                                                                           promulgated
                                                                                                                           thereunder)
                                                                                                                           of
                                                                                                                           the
                                                                                                                           transactions
                                                                                                                           contemplated
                                                                                                                           by
                                                                                                                           this
                                                                                                                           Agreement;
                                                                                                                           provided,
                                                                                                                           however,
                                                                                                                           that
                                                                                                                           except
                                                                                                                           to
                                                                                                                           the
                                                                                                                           extent
                                                                                                                           otherwise
                                                                                                                           provided
                                                                                                                           above
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Section
                                                                                                                           7.4,
                                                                                                                           no
                                                                                                                           Party
                                                                                                                           shall
                                                                                                                           disclose
                                                                                                                           any
                                                                                                                           information
                                                                                                                           pursuant
                                                                                                                           to
                                                                                                                           this
                                                                                                                           Section
                                                                                                                           7.4
                                                                                                                           that
                                                                                                                           is
                                                                                                                           not
                                                                                                                           necessary
                                                                                                                           to
                                                                                                                           understanding
                                                                                                                           the
                                                                                                                           tax
                                                                                                                           treatment
                                                                                                                           and
                                                                                                                           tax
                                                                                                                           structure
                                                                                                                           of
                                                                                                                           any
                                                                                                                           possible
                                                                                                                           transactions
                                                                                                                           (including
                                                                                                                           the
                                                                                                                           identity
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Parties,
                                                                                                                           any
                                                                                                                           information
                                                                                                                           that
                                                                                                                           could
                                                                                                                           lead
                                                                                                                           another
                                                                                                                           to
                                                                                                                           determine
                                                                                                                           the
                                                                                                                           identity
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Parties,
                                                                                                                           any
                                                                                                                           other
                                                                                                                           information
                                                                                                                           to
                                                                                                                           the
                                                                                                                           extent
                                                                                                                           that
                                                                                                                           such
                                                                                                                           disclosure
                                                                                                                           could
                                                                                                                           result
                                                                                                                           in
                                                                                                                           a violation
                                                                                                                           of
                                                                                                                           any
                                                                                                                           federal
                                                                                                                           or
                                                                                                                           state
                                                                                                                           securities
                                                                                                                           Law,
                                                                                                                           or
                                                                                                                           the
                                                                                                                           general
                                                                                                                           terms
                                                                                                                           and
                                                                                                                           conditions
                                                                                                                           and
                                                                                                                           other
                                                                                                                           commercial
                                                                                                                           terms
                                                                                                                           of
                                                                                                                           the
                                                                                                                           arrangements
                                                                                                                           contemplated
                                                                                                                           by
                                                                                                                           this
                                                                                                                           Agreement).

 

		7.5	Remedy.
                                                                                                                           It
                                                                                                                           is
                                                                                                                           understood
                                                                                                                           and
                                                                                                                           agreed
                                                                                                                           that
                                                                                                                           in
                                                                                                                           the
                                                                                                                           event
                                                                                                                           of
                                                                                                                           a breach
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           7
                                                                                                                           damages
                                                                                                                           will
                                                                                                                           not
                                                                                                                           be
                                                                                                                           an
                                                                                                                           adequate
                                                                                                                           remedy
                                                                                                                           and
                                                                                                                           the
                                                                                                                           Party
                                                                                                                           not
                                                                                                                           in
                                                                                                                           breach
                                                                                                                           hereof
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           entitled
                                                                                                                           to
                                                                                                                           injunctive
                                                                                                                           relief
                                                                                                                           to
                                                                                                                           restrain
                                                                                                                           any
                                                                                                                           such
                                                                                                                           breach,
                                                                                                                           threatened
                                                                                                                           or
                                                                                                                           actual,
                                                                                                                           notwithstanding
                                                                                                                           Section 13.3,
                                                                                                                           without
                                                                                                                           the
                                                                                                                           need
                                                                                                                           to
                                                                                                                           prove
                                                                                                                           irreparable
                                                                                                                           harm
                                                                                                                           or
                                                                                                                           to
                                                                                                                           post
                                                                                                                           a bond
                                                                                                                           or
                                                                                                                           other
                                                                                                                           security,
                                                                                                                           in
                                                                                                                           addition
                                                                                                                           to
                                                                                                                           any
                                                                                                                           other
                                                                                                                           remedies
                                                                                                                           that
                                                                                                                           may
                                                                                                                           be
                                                                                                                           available
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Party
                                                                                                                           not
                                                                                                                           in
                                                                                                                           breach
                                                                                                                           hereof
                                                                                                                           under
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           at
                                                                                                                           law,
                                                                                                                           in
                                                                                                                           equity,
                                                                                                                           or
                                                                                                                           otherwise.

 

		7.6	Return
                                                                                                                           of
                                                                                                                           Confidential
                                                                                                                           Information.
                                                                                                                           Each
                                                                                                                           Receiving
                                                                                                                           Party,
                                                                                                                           shall,
                                                                                                                           upon
                                                                                                                           written
                                                                                                                           request
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Disclosing
                                                                                                                           Party
                                                                                                                           or
                                                                                                                           upon
                                                                                                                           expiration
                                                                                                                           or
                                                                                                                           termination
                                                                                                                           of
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           either
                                                                                                                           promptly
                                                                                                                           return
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Disclosing
                                                                                                                           Party,
                                                                                                                           or
                                                                                                                           destroy
                                                                                                                           and
                                                                                                                           certify
                                                                                                                           in
                                                                                                                           writing
                                                                                                                           to
                                                                                                                           the
                                                                                                                           Disclosing
                                                                                                                           Party
                                                                                                                           the
                                                                                                                           destruction
                                                                                                                           of,
                                                                                                                           any
                                                                                                                           and
                                                                                                                           all
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           the
                                                                                                                           Disclosing
                                                                                                                           Party
                                                                                                                           (whether
                                                                                                                           in
                                                                                                                           hard
                                                                                                                           copy,
                                                                                                                           electronic
                                                                                                                           format
                                                                                                                           or
                                                                                                                           otherwise
                                                                                                                           and
                                                                                                                           whether
                                                                                                                           stand-alone
                                                                                                                           or
                                                                                                                           included
                                                                                                                           in
                                                                                                                           any,
                                                                                                                           or
                                                                                                                           that
                                                                                                                           constitute,
                                                                                                                           other
                                                                                                                           materials
                                                                                                                           or
                                                                                                                           documents)
                                                                                                                           in
                                                                                                                           the
                                                                                                                           Receiving
                                                                                                                           Party’s
                                                                                                                           possession.

 

		7.7	No
                                                                                                                           Right
                                                                                                                           or
                                                                                                                           License.
                                                                                                                           Each
                                                                                                                           Party
                                                                                                                           acknowledges
                                                                                                                           and
                                                                                                                           agrees
                                                                                                                           that
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Technology
                                                                                                                           and
                                                                                                                           the
                                                                                                                           BRNI
                                                                                                                           Data
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           deemed
                                                                                                                           to
                                                                                                                           be
                                                                                                                           the
                                                                                                                           Confidential
                                                                                                                           Information
                                                                                                                           of
                                                                                                                           BRNI
                                                                                                                           and
                                                                                                                           NRV
                                                                                                                           II.
                                                                                                                           Nothing
                                                                                                                           in
                                                                                                                           this
                                                                                                                           Article
                                                                                                                           7
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           construed
                                                                                                                           as
                                                                                                                           granting
                                                                                                                           to,
                                                                                                                           or
                                                                                                                           conferring
                                                                                                                           on,
                                                                                                                           the
                                                                                                                           other
                                                                                                                           Party,
                                                                                                                           expressly
                                                                                                                           or
                                                                                                                           impliedly,
                                                                                                                           any
                                                                                                                           rights
                                                                                                                           or
                                                                                                                           license
                                                                                                                           to
                                                                                                                           any
                                                                                                                           Confidential
                                                                                                                           Information.

 

    	 

    	 

    

 

		8.	Representations and Warranties

 

		8.1	Mutual
                                                                                                                           Representations,
                                                                                                                           Warranties,
                                                                                                                           and
                                                                                                                           Covenants.
                                                                                                                           Each
                                                                                                                           Party
                                                                                                                           hereby
                                                                                                                           represents,
                                                                                                                           warrants,
                                                                                                                           and
                                                                                                                           covenants
                                                                                                                           that:

 

		(i)	such Party is duly organized and validly existing under the Laws of its jurisdiction of incorporation
or formation and it has full corporate or other power and authority, has the rights necessary, and has taken all corporate or other
action necessary, to enter into and perform this Agreement;

 

		(ii)	(a) this Agreement is a legal and valid obligation binding upon such Party and enforceable in accordance
with its terms, (b) the execution, delivery, and performance of this Agreement by such Party do not conflict with any agreement,
instrument or understanding, oral or written, by which it is bound, and, to its knowledge as of the Execution Date, does not violate
any Law, and (c) the individual executing this Agreement on such Party’s behalf has been duly authorized to do so by all
requisite corporate or other action; and

 

		(iii)	no authorization, consent, approval, license, exemption of, or filing or registration with any
Governmental Authority, under any applicable Laws, is or shall be necessary for, or in connection with, the transactions contemplated
by this Agreement.

 

		8.2	Representations,
                                                                                                                           Warranties,
                                                                                                                           and
                                                                                                                           Covenants
                                                                                                                           by
                                                                                                                           Neurotrope.
                                                                                                                           Neurotrope
                                                                                                                           hereby
                                                                                                                           represents,
                                                                                                                           warrants,
                                                                                                                           and
                                                                                                                           covenants
                                                                                                                           that,
                                                                                                                           during
                                                                                                                           the
                                                                                                                           Term:
                                                                                                                           (i)
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products
                                                                                                                           shall
                                                                                                                           be
                                                                                                                           developed,
                                                                                                                           used,
                                                                                                                           manufactured,
                                                                                                                           marketed,
                                                                                                                           offered
                                                                                                                           for
                                                                                                                           sale,
                                                                                                                           sold,
                                                                                                                           distributed,
                                                                                                                           imported
                                                                                                                           and
                                                                                                                           exported
                                                                                                                           by
                                                                                                                           each
                                                                                                                           of
                                                                                                                           Neurotrope
                                                                                                                           and
                                                                                                                           its
                                                                                                                           sublicensees
                                                                                                                           in
                                                                                                                           accordance
                                                                                                                           with
                                                                                                                           all
                                                                                                                           applicable
                                                                                                                           Laws;
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           that
                                                                                                                           each
                                                                                                                           of
                                                                                                                           Neurotrope
                                                                                                                           and
                                                                                                                           its
                                                                                                                           sublicensees
                                                                                                                           shall
                                                                                                                           obtain
                                                                                                                           all
                                                                                                                           licenses
                                                                                                                           and
                                                                                                                           approvals
                                                                                                                           of
                                                                                                                           Governmental
                                                                                                                           Authorities
                                                                                                                           necessary
                                                                                                                           to
                                                                                                                           develop,
                                                                                                                           use,
                                                                                                                           manufacture,
                                                                                                                           market,
                                                                                                                           sell,
                                                                                                                           offer
                                                                                                                           for
                                                                                                                           sale,
                                                                                                                           distribute
                                                                                                                           and
                                                                                                                           import
                                                                                                                           the
                                                                                                                           Licensed
                                                                                                                           Products.

 

		8.3	Representations,
                                                                                                                                  Warranties,
                                                                                                                                  and
                                                                                                                                  Covenants
                                                                                                                                  by
                                                                                                                                  BRNI.
                                                                                                                                  BRNI
                                                                                                                                  hereby
                                                                                                                                  represents,
                                                                                                                                  warrants,
                                                                                                                                  and
                                                                                                                                  covenants
                                                                                                                                  that
                                                                                                                                  to
                                                                                                                                  its
                                                                                                                                  knowledge,
                                                                                                                                  as
                                                                                                                                  of
                                                                                                                                  the
                                                                                                                                  Execution
                                                                                                                                  Date:
                                                                                                                                  (i)
                                                                                                                                  none
                                                                                                                                  of
                                                                                                                                  the
                                                                                                                                  data
                                                                                                                                  provided
                                                                                                                                  by
                                                                                                                                  BRNI
                                                                                                                                  to
                                                                                                                                  Dr.
                                                                                                                                  John
                                                                                                                                  Abeles
                                                                                                                                  or
                                                                                                                                  Dr.
                                                                                                                                  Jim
                                                                                                                                  New
                                                                                                                                  was
                                                                                                                                  intentionally
                                                                                                                                  falsified
                                                                                                                                  by
                                                                                                                                  BRNI;
                                                                                                                                  (ii)
                                                                                                                                  BRNI
                                                                                                                                  has
                                                                                                                                  provided
                                                                                                                                  to
                                                                                                                                  Dr.
                                                                                                                                  John
                                                                                                                                  Abeles
                                                                                                                                  or
                                                                                                                                  Dr.
                                                                                                                                  Jim
                                                                                                                                  New
                                                                                                                                  the
                                                                                                                                  information
                                                                                                                                  related
                                                                                                                                  to
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  IP
                                                                                                                                  in
                                                                                                                                  BRNI’s
                                                                                                                                  possession
                                                                                                                                  that
                                                                                                                                  is
                                                                                                                                  reasonably
                                                                                                                                  material
                                                                                                                                  to
                                                                                                                                  the
                                                                                                                                  rights
                                                                                                                                  and
                                                                                                                                  licenses
                                                                                                                                  granted
                                                                                                                                  hereunder;
                                                                                                                                  and
                                                                                                                                  (iii)
                                                                                                                                  the
                                                                                                                                  Licensed
                                                                                                                                  IP
                                                                                                                                  is
                                                                                                                                  free
                                                                                                                                  and
                                                                                                                                  clear
                                                                                                                                  of
                                                                                                                                  all
                                                                                                                                  security
                                                                                                                                  interests.

 

		8.4	Disclaimer
                                                                                                                           of
                                                                                                                           Warranties.
                                                                                                                           EXCEPT
                                                                                                                           AS
                                                                                                                           SET
                                                                                                                           FORTH
                                                                                                                           IN
                                                                                                                           THIS
                                                                                                                           ARTICLE
                                                                                                                           8,
                                                                                                                           EACH
                                                                                                                           PARTY
                                                                                                                           EXPRESSLY
                                                                                                                           DISCLAIMS
                                                                                                                           ANY
                                                                                                                           AND
                                                                                                                           ALL
                                                                                                                           REPRESENTATIONS
                                                                                                                           AND
                                                                                                                           WARRANTIES
                                                                                                                           (EXPRESS,
                                                                                                                           IMPLIED,
                                                                                                                           STATUTORY,
                                                                                                                           OR
                                                                                                                           OTHERWISE)
                                                                                                                           WITH
                                                                                                                           RESPECT
                                                                                                                           TO
                                                                                                                           THE
                                                                                                                           LICENSED
                                                                                                                           IP,
                                                                                                                           THIS
                                                                                                                           AGREEMENT,
                                                                                                                           OR
                                                                                                                           ANY
                                                                                                                           OTHER
                                                                                                                           SUBJECT
                                                                                                                           MATTER
                                                                                                                           RELATING
                                                                                                                           TO
                                                                                                                           THIS
                                                                                                                           AGREEMENT,
                                                                                                                           INCLUDING
                                                                                                                           ANY
                                                                                                                           WARRANTY
                                                                                                                           OF
                                                                                                                           MERCHANTABILITY,
                                                                                                                           NON-INFRINGEMENT,
                                                                                                                           FITNESS
                                                                                                                           FOR
                                                                                                                           A PARTICULAR
                                                                                                                           PURPOSE,
                                                                                                                           OR
                                                                                                                           OWNERSHIP,
                                                                                                                           SCOPE,
                                                                                                                           VALIDITY
                                                                                                                           OR
                                                                                                                           ENFORCEABILITY
                                                                                                                           OF
                                                                                                                           INTELLECTUAL
                                                                                                                           PROPERTY
                                                                                                                           RIGHTS.

 

    	 

    	 

    

 

		9.	Limitations of Liability

 

		9.1	Exclusion
                                                                                                                           of
                                                                                                                           Consequential
                                                                                                                           Damages.
                                                                                                                           EXCEPT
                                                                                                                           FOR
                                                                                                                           (I)
                                                                                                                           NEUROTROPE’S
                                                                                                                           BREACH
                                                                                                                           OF
                                                                                                                           ARTICLE
                                                                                                                           2,
                                                                                                                           (II)
                                                                                                                           A PARTY’S
                                                                                                                           BREACH
                                                                                                                           OF
                                                                                                                           ARTICLE
                                                                                                                           7,
                                                                                                                           (III) A
                                                                                                                           PARTY’S
                                                                                                                           OBLIGATIONS
                                                                                                                           UNDER
                                                                                                                           ARTICLE
                                                                                                                           10,
                                                                                                                           AND
                                                                                                                           (IV) NEUROTROPE’S
                                                                                                                           OBLIGATIONS
                                                                                                                           TO
                                                                                                                           PAY
                                                                                                                           ANY
                                                                                                                           AMOUNTS
                                                                                                                           DUE
                                                                                                                           UNDER
                                                                                                                           THIS
                                                                                                                           AGREEMENT,
                                                                                                                           IN
                                                                                                                           NO
                                                                                                                           EVENT
                                                                                                                           SHALL
                                                                                                                           ANY
                                                                                                                           PARTY
                                                                                                                           (OR
                                                                                                                           ANY
                                                                                                                           OF
                                                                                                                           ITS
                                                                                                                           AFFILIATES
                                                                                                                           OR
                                                                                                                           ITS
                                                                                                                           OR
                                                                                                                           THEIR
                                                                                                                           RESPECTIVE
                                                                                                                           DIRECTORS,
                                                                                                                           OFFICERS,
                                                                                                                           EMPLOYEES
                                                                                                                           OR
                                                                                                                           AGENTS)
                                                                                                                           BE
                                                                                                                           LIABLE
                                                                                                                           TO
                                                                                                                           ANY
                                                                                                                           OTHER
                                                                                                                           PARTY
                                                                                                                           (OR
                                                                                                                           ANY
                                                                                                                           OF
                                                                                                                           ITS
                                                                                                                           AFFILIATES
                                                                                                                           OR
                                                                                                                           ITS
                                                                                                                           OR
                                                                                                                           THEIR
                                                                                                                           RESPECTIVE
                                                                                                                           DIRECTORS,
                                                                                                                           OFFICERS,
                                                                                                                           EMPLOYEES
                                                                                                                           OR
                                                                                                                           AGENTS)
                                                                                                                           FOR
                                                                                                                           ANY
                                                                                                                           INDIRECT,
                                                                                                                           SPECIAL,
                                                                                                                           INCIDENTAL,
                                                                                                                           EXEMPLARY,
                                                                                                                           OR
                                                                                                                           CONSEQUENTIAL
                                                                                                                           DAMAGES
                                                                                                                           OF
                                                                                                                           ANY
                                                                                                                           KIND
                                                                                                                           ARISING
                                                                                                                           OUT
                                                                                                                           OF
                                                                                                                           OR
                                                                                                                           IN
                                                                                                                           CONNECTION
                                                                                                                           WITH
                                                                                                                           THIS
                                                                                                                           AGREEMENT,
                                                                                                                           HOWEVER
                                                                                                                           CAUSED
                                                                                                                           AND
                                                                                                                           ON
                                                                                                                           ANY
                                                                                                                           THEORY
                                                                                                                           OF
                                                                                                                           LIABILITY
                                                                                                                           (WHETHER
                                                                                                                           IN
                                                                                                                           CONTRACT,
                                                                                                                           TORT
                                                                                                                           (INCLUDING
                                                                                                                           NEGLIGENCE),
                                                                                                                           STRICT
                                                                                                                           LIABILITY,
                                                                                                                           OR
                                                                                                                           OTHERWISE),
                                                                                                                           EVEN
                                                                                                                           IF
                                                                                                                           SUCH
                                                                                                                           DAMAGES
                                                                                                                           WERE
                                                                                                                           FORESEEABLE
                                                                                                                           OR
                                                                                                                           SUCH
                                                                                                                           PARTY
                                                                                                                           WAS
                                                                                                                           ADVISED
                                                                                                                           OR
                                                                                                                           OTHERWISE
                                                                                                                           AWARE
                                                                                                                           OF
                                                                                                                           THE
                                                                                                                           LIKELIHOOD
                                                                                                                           OF
                                                                                                                           SUCH
                                                                                                                           DAMAGES.

 

		9.2	Insurance.
                                                                                                                           During
                                                                                                                           the
                                                                                                                           Term
                                                                                                                           and
                                                                                                                           for
                                                                                                                           a period
                                                                                                                           of
                                                                                                                           at
                                                                                                                           least
                                                                                                                           three
                                                                                                                           (3)
                                                                                                                           years
                                                                                                                           thereafter,
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           carry
                                                                                                                           and
                                                                                                                           maintain
                                                                                                                           at
                                                                                                                           its
                                                                                                                           sole
                                                                                                                           expense
                                                                                                                           (including
                                                                                                                           any
                                                                                                                           policy
                                                                                                                           deductibles
                                                                                                                           or
                                                                                                                           self-insured
                                                                                                                           retentions)
                                                                                                                           customary
                                                                                                                           insurance
                                                                                                                           coverage
                                                                                                                           that
                                                                                                                           is
                                                                                                                           (i)
                                                                                                                           reasonable
                                                                                                                           under
                                                                                                                           circumstances
                                                                                                                           with
                                                                                                                           respect
                                                                                                                           to
                                                                                                                           this
                                                                                                                           Agreement,
                                                                                                                           consistent
                                                                                                                           with
                                                                                                                           Neurotrope’s
                                                                                                                           business
                                                                                                                           requirements
                                                                                                                           and
                                                                                                                           (ii)
                                                                                                                           covers
                                                                                                                           all
                                                                                                                           reasonably
                                                                                                                           foreseeable
                                                                                                                           losses
                                                                                                                           or
                                                                                                                           damages
                                                                                                                           that
                                                                                                                           may
                                                                                                                           arise
                                                                                                                           from
                                                                                                                           this
                                                                                                                           Agreement
                                                                                                                           (on
                                                                                                                           a worldwide
                                                                                                                           basis,
                                                                                                                           except
                                                                                                                           for
                                                                                                                           coverage
                                                                                                                           where
                                                                                                                           separate
                                                                                                                           non-U.S.
                                                                                                                           policies
                                                                                                                           apply),
                                                                                                                           including
                                                                                                                           general
                                                                                                                           liability
                                                                                                                           (including
                                                                                                                           product
                                                                                                                           liability),
                                                                                                                           errors
                                                                                                                           and
                                                                                                                           omissions,
                                                                                                                           workers
                                                                                                                           compensation
                                                                                                                           and
                                                                                                                           other
                                                                                                                           customary
                                                                                                                           coverages,
                                                                                                                           from
                                                                                                                           an
                                                                                                                           insurance
                                                                                                                           company
                                                                                                                           with
                                                                                                                           claims
                                                                                                                           offices
                                                                                                                           in
                                                                                                                           the
                                                                                                                           U.S.
                                                                                                                           (except
                                                                                                                           for
                                                                                                                           coverage
                                                                                                                           where
                                                                                                                           separate
                                                                                                                           non-U.S.
                                                                                                                           policies
                                                                                                                           apply)
                                                                                                                           that
                                                                                                                           has
                                                                                                                           a Best’s
                                                                                                                           Rating
                                                                                                                           of
                                                                                                                           A-
                                                                                                                           or
                                                                                                                           higher
                                                                                                                           and
                                                                                                                           a Financial
                                                                                                                           Size
                                                                                                                           Category
                                                                                                                           of
                                                                                                                           Class
                                                                                                                           VII
                                                                                                                           or
                                                                                                                           higher,
                                                                                                                           as
                                                                                                                           such
                                                                                                                           ratings
                                                                                                                           and
                                                                                                                           categories
                                                                                                                           are
                                                                                                                           assigned
                                                                                                                           by
                                                                                                                           A.M.
                                                                                                                           Best
                                                                                                                           Company,
                                                                                                                           Inc.,
                                                                                                                           and
                                                                                                                           in
                                                                                                                           all
                                                                                                                           cases,
                                                                                                                           naming
                                                                                                                           BRNI
                                                                                                                           as
                                                                                                                           an
                                                                                                                           additional
                                                                                                                           insured.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           provide
                                                                                                                           BRNI
                                                                                                                           with
                                                                                                                           a copy
                                                                                                                           of
                                                                                                                           the
                                                                                                                           fully
                                                                                                                           paid
                                                                                                                           policies
                                                                                                                           or
                                                                                                                           certificates
                                                                                                                           of
                                                                                                                           insurance
                                                                                                                           by
                                                                                                                           no
                                                                                                                           later
                                                                                                                           than
                                                                                                                           the
                                                                                                                           first
                                                                                                                           day
                                                                                                                           such
                                                                                                                           coverage
                                                                                                                           takes
                                                                                                                           effect.
                                                                                                                           Neurotrope
                                                                                                                           shall
                                                                                                                           provide
                                                                                                                           BRNI
                                                                                                                           with
                                                                                                                           written
                                                                                                                           notice
                                                                                                                           at
                                                                                                                           least
                                                                                                                           thirty
                                                                                                                           (30)
                                                                                                                           days
                                                                                                                           prior
                                                                                                                           to
                                                                                                                           any
                                                                                                                           expiration,
                                                                                                                           renewal,
                                                                                                                           modification
                                                                                                                           or
                                                                                                                           termination
                                                                                                                           of
                                                                                                                           any
                                                                                                                           such
                                                                                                                           coverage.

 

		10.	Indemnities

 

		10.1	Indemnification.

 

		10.1.1	By Neurotrope. Neurotrope shall defend, indemnify and hold harmless the BRNI Indemnitees
from and against any Losses incurred by any BRNI Indemnitee in connection with all Third Party Claims arising from, resulting from
or relating to: (i) Neurotrope’s or any of its sublicensees’ breach of any terms or conditions of this Agreement;
(ii) any negligence, gross negligence, willful misconduct or other act or omission of Neurotrope or any of its sublicensees in
connection with this Agreement; (iii) Neurotrope’s or any of its sublicensees’ use of, or conduct regarding, Licensed
Products or Licensed IP, including any claims of product liability, defect, warranty, recall, false advertising, personal injury,
death, or damage to property; or (iv) any violation of any Laws by any Licensed Product, Neurotrope or any of its sublicensees.

 

    	 

    	 

    

 

		10.1.2	By BRNI. BRNI shall defend, indemnity and hold harmless the Neurotrope Indemnitees from
and against any Losses incurred by any Neurotrope Indemnitee in connection with all Third Party Claims arising from, resulting
from or relating to: (i) BRNI’s breach of any terms or conditions of this Agreement; or (ii) any violation of any Laws by
BRNI.

 

		10.2	Right
                                                                                                                            to
                                                                                                                            Participate
                                                                                                                            in
                                                                                                                            Defense.
                                                                                                                            The
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            entitled
                                                                                                                            to
                                                                                                                            participate
                                                                                                                            in
                                                                                                                            the
                                                                                                                            defense
                                                                                                                            of
                                                                                                                            any
                                                                                                                            Third
                                                                                                                            Party
                                                                                                                            Claim
                                                                                                                            and
                                                                                                                            to
                                                                                                                            employ
                                                                                                                            counsel
                                                                                                                            of
                                                                                                                            its
                                                                                                                            choice
                                                                                                                            for
                                                                                                                            such
                                                                                                                            purpose;
                                                                                                                            provided,
                                                                                                                            however,
                                                                                                                            that
                                                                                                                            such
                                                                                                                            employment
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            at
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee’s
                                                                                                                            own
                                                                                                                            expense
                                                                                                                            unless
                                                                                                                            the
                                                                                                                            Indemnifying
                                                                                                                            Party
                                                                                                                            has
                                                                                                                            failed
                                                                                                                            to
                                                                                                                            assume
                                                                                                                            the
                                                                                                                            defense
                                                                                                                            (in
                                                                                                                            which
                                                                                                                            case
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            the
                                                                                                                            right
                                                                                                                            (but
                                                                                                                            not
                                                                                                                            the
                                                                                                                            obligation)
                                                                                                                            to
                                                                                                                            control
                                                                                                                            the
                                                                                                                            defense
                                                                                                                            and
                                                                                                                            the
                                                                                                                            Indemnifying
                                                                                                                            Party
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            responsible
                                                                                                                            for
                                                                                                                            all
                                                                                                                            such
                                                                                                                            expenses
                                                                                                                            (in
                                                                                                                            addition
                                                                                                                            to
                                                                                                                            any
                                                                                                                            Losses
                                                                                                                            for
                                                                                                                            which
                                                                                                                            the
                                                                                                                            Indemnifying
                                                                                                                            Party
                                                                                                                            is
                                                                                                                            responsible
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            Section
                                                                                                                            10.1).
                                                                                                                            If
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            elects
                                                                                                                            to
                                                                                                                            participate
                                                                                                                            in
                                                                                                                            its
                                                                                                                            own
                                                                                                                            defense,
                                                                                                                            the
                                                                                                                            Indemnifying
                                                                                                                            Party
                                                                                                                            shall
                                                                                                                            consider
                                                                                                                            in
                                                                                                                            good
                                                                                                                            faith
                                                                                                                            the
                                                                                                                            views
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            and
                                                                                                                            its
                                                                                                                            counsel
                                                                                                                            and
                                                                                                                            to
                                                                                                                            keep
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            and
                                                                                                                            its
                                                                                                                            counsel
                                                                                                                            reasonably
                                                                                                                            informed
                                                                                                                            of
                                                                                                                            the
                                                                                                                            progress
                                                                                                                            of
                                                                                                                            the
                                                                                                                            defense,
                                                                                                                            litigation,
                                                                                                                            arbitration,
                                                                                                                            or
                                                                                                                            settlement
                                                                                                                            discussions
                                                                                                                            relating
                                                                                                                            to
                                                                                                                            such
                                                                                                                            Third
                                                                                                                            Party
                                                                                                                            Claim.

 

		10.3	Settlement.
                                                                                                                            The
                                                                                                                            Indemnifying
                                                                                                                            Party
                                                                                                                            shall
                                                                                                                            not
                                                                                                                            settle
                                                                                                                            or
                                                                                                                            compromise
                                                                                                                            any
                                                                                                                            Third
                                                                                                                            Party
                                                                                                                            Claims
                                                                                                                            against
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitees
                                                                                                                            without
                                                                                                                            with
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee’s
                                                                                                                            prior
                                                                                                                            written
                                                                                                                            consent,
                                                                                                                            unless
                                                                                                                            such
                                                                                                                            settlement
                                                                                                                            or
                                                                                                                            compromise:
                                                                                                                            (i)
                                                                                                                            includes
                                                                                                                            an
                                                                                                                            unconditional
                                                                                                                            release
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            from
                                                                                                                            all
                                                                                                                            liability
                                                                                                                            arising
                                                                                                                            out
                                                                                                                            of
                                                                                                                            such
                                                                                                                            Third
                                                                                                                            Party
                                                                                                                            Claims;
                                                                                                                            (ii)
                                                                                                                            is
                                                                                                                            solely
                                                                                                                            monetary
                                                                                                                            in
                                                                                                                            nature;
                                                                                                                            and
                                                                                                                            (iii)
                                                                                                                            does
                                                                                                                            not
                                                                                                                            include
                                                                                                                            remedial
                                                                                                                            or
                                                                                                                            equitable
                                                                                                                            measures
                                                                                                                            or
                                                                                                                            relief
                                                                                                                            (including
                                                                                                                            any
                                                                                                                            injunction),
                                                                                                                            a
                                                                                                                            statement
                                                                                                                            as
                                                                                                                            to,
                                                                                                                            or
                                                                                                                            an
                                                                                                                            admission
                                                                                                                            of,
                                                                                                                            fault,
                                                                                                                            culpability
                                                                                                                            or
                                                                                                                            failure
                                                                                                                            to
                                                                                                                            act
                                                                                                                            by
                                                                                                                            or
                                                                                                                            on
                                                                                                                            behalf
                                                                                                                            of,
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee
                                                                                                                            or
                                                                                                                            otherwise
                                                                                                                            materially
                                                                                                                            adversely
                                                                                                                            affect
                                                                                                                            the
                                                                                                                            Claiming
                                                                                                                            Indemnitee.
                                                                                                                            The
                                                                                                                            Indemnifying
                                                                                                                            Party
                                                                                                                            shall
                                                                                                                            not
                                                                                                                            admit
                                                                                                                            any
                                                                                                                            liability
                                                                                                                            with
                                                                                                                            respect
                                                                                                                            to
                                                                                                                            any
                                                                                                                            Third
                                                                                                                            Party
                                                                                                                            Claim
                                                                                                                            without
                                                                                                                            the
                                                                                                                            prior
                                                                                                                            consent
                                                                                                                            of
                                                                                                                            Claiming
                                                                                                                            Indemnitee.

 

		11.	Term and Termination

 

		11.1	Term.
                                                                                                                            This
                                                                                                                            Agreement
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            effective
                                                                                                                            as
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Execution
                                                                                                                            Date
                                                                                                                            and,
                                                                                                                            subject
                                                                                                                            to
                                                                                                                            termination
                                                                                                                            in
                                                                                                                            accordance
                                                                                                                            with
                                                                                                                            Section
                                                                                                                            11.2,
                                                                                                                            shall
                                                                                                                            continue
                                                                                                                            during
                                                                                                                            the
                                                                                                                            Term.

 

		11.2	Termination.

 

		11.2.1	By BRNI. BRNI may terminate this Agreement pursuant to Section 12.1(i). In addition,
upon written notice of termination to Neurotrope, BRNI may elect, in its sole discretion, to terminate this Agreement, effectively
immediately, in the event that (i) Neurotrope fails to complete the A Round Financing by February 28, 2013 (or such other
date as agreed by a unanimous vote of all of the Directors (as defined in the Stockholders Agreement) of the Board (as defined
in the Stockholders Agreement)) or (ii) Neurotrope challenges the ownership, scope, validity or enforceability of any Licensed
IP.

 

    	 

    	 

    

 

		11.2.2	By Either Party. Upon written notice of termination to the other Party, BRNI or Neurotrope
may terminate this Agreement or the applicable SOW thirty (30) days after the date of such notice of termination, in the event
that:

 

		(i)	the other Party materially breaches any provisions of this Agreement or a commits a series of breaches
that over time that taken together constitute a material breach of this Agreement, and (a) such material breach is incapable of
cure or (b) with respect to such material breaches capable of cure, the breaching Party does not cure such material breach within
sixty (60) days from notice of such material breach from the non-breaching Party;

 

		(ii)	the other Party (a) files for bankruptcy, (b) is the subject of any proceedings related to its
liquidation, insolvency, or the appointment of a receiver or similar officer for it, which proceedings are not dismissed within
sixty (60) days after their commencement, (c) makes an assignment for the benefit of all or substantially all of its creditors,
or (d) enters into an agreement for the composition, extension, or readjustment of substantially all of its obligations; or

 

		(iii)	the Stockholders Agreement is terminated.

 

		11.2.3	Automatically. This Agreement shall terminate automatically if (i) BRNI elects to proceed
with clause (ii) of Section 12.1 and (ii) BRNI, on the one hand, and John Abeles and Jim New, on the other hand, do
not agree, within ninety (90) days of such election by BRNI, to a new target amount for Neurotrope to raise during A Round Financing
and the intended use of such new amount following the completion of the new A Round Financing (and amend this Agreement to reflect
such agreement).

 

		11.2.4	Termination of an SOW. Expiration or termination of this Agreement shall result in the automatic
termination of all SOWs then in effect. Expiration or termination of any or all SOWs shall not, by itself, result in the termination
of this Agreement or any other SOW.

 

		11.3	Effect
                                                                                                                                   of
                                                                                                                                   Termination
                                                                                                                                   or
                                                                                                                                   Expiration.

 

		11.3.1	Survival. The following Articles and Sections shall survive the expiration or termination
of the Term: Article 1, Article 4, Article 5 (other than Section 5.7), Article 7, Section 8.4,
Article 9, Article 10, Section 11.3, Section 12.2 and Article 13.

 

		11.3.2	Certain Post-Termination Obligations. Upon any expiration or termination of the Term: (i)
all licenses granted hereunder shall terminate immediately; (ii) Neurotrope shall immediately cease, and shall cause its sublicensees
to immediately cease, all use of the Licensed IP; (iii) upon BRNI’s request, Neurotrope shall (a) provide BRNI with copies
of agreements with Third Parties related to obtaining licenses or approvals from Governmental Authorities and sublicense agreements
with Third Parties and (b) provide BRNI with all assistance and cooperation in transferring any such agreement to BRNI (including
obtaining consents); and (iv) Neurotrope shall, and shall cause its designated Affiliates to, as applicable, transfer to BRNI,
at Neurotrope’s cost and expense, all licenses and approvals, and filings and applications therefor, held in the name of
Neurotrope (or its designated Affiliate) pursuant to Section 6.4.

 

    	 

    	 

    

 

		11.3.3	Payments. No payment made under this Agreement shall be refundable upon the expiration or
termination of this Agreement and no termination or expiration of this Agreement shall relieve Neurotrope of its obligations to
pay any amounts due or owing to BRNI. Upon expiration or termination of this Agreement, all Royalty obligations or other amounts
still due and owing by Neurotrope shall be accelerated and shall immediately become due and payable.

 

		12.	BRNI Third Party Licensor Option

 

		12.1	BRNI
                                                                                                                            Option
                                                                                                                            to
                                                                                                                            Terminate
                                                                                                                            or
                                                                                                                            Reduce
                                                                                                                            License
                                                                                                                            Scope
                                                                                                                            Prior
                                                                                                                            to
                                                                                                                            the
                                                                                                                            Completion
                                                                                                                            of
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing.
                                                                                                                            If,
                                                                                                                            prior
                                                                                                                            to
                                                                                                                            the
                                                                                                                            date
                                                                                                                            of
                                                                                                                            the
                                                                                                                            completion
                                                                                                                            of
                                                                                                                            the
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing,
                                                                                                                            BRNI
                                                                                                                            or
                                                                                                                            NRV
                                                                                                                            II
                                                                                                                            (or
                                                                                                                            both
                                                                                                                            of
                                                                                                                            them)
                                                                                                                            enter
                                                                                                                            into
                                                                                                                            an
                                                                                                                            agreement
                                                                                                                            that
                                                                                                                            grants
                                                                                                                            or
                                                                                                                            agrees
                                                                                                                            to
                                                                                                                            grant
                                                                                                                            to
                                                                                                                            any
                                                                                                                            Person
                                                                                                                            (other
                                                                                                                            than
                                                                                                                            the
                                                                                                                            Company)
                                                                                                                            a
                                                                                                                            license
                                                                                                                            or
                                                                                                                            sublicense,
                                                                                                                            respectively,
                                                                                                                            to
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            Technology
                                                                                                                            referenced
                                                                                                                            in
                                                                                                                            clause
                                                                                                                            (i)
                                                                                                                            or
                                                                                                                            clause
                                                                                                                            (ii)
                                                                                                                            of
                                                                                                                            the
                                                                                                                            definition
                                                                                                                            of
                                                                                                                            Licensed
                                                                                                                            Technology
                                                                                                                            or
                                                                                                                            one
                                                                                                                            (1)
                                                                                                                            or
                                                                                                                            more
                                                                                                                            Licensed
                                                                                                                            Patents
                                                                                                                            covering
                                                                                                                            any
                                                                                                                            such
                                                                                                                            Licensed
                                                                                                                            Technology,
                                                                                                                            then
                                                                                                                            BRNI
                                                                                                                            may
                                                                                                                            elect,
                                                                                                                            in
                                                                                                                            its
                                                                                                                            sole
                                                                                                                            discretion:
                                                                                                                            (i)
                                                                                                                            to
                                                                                                                            terminate
                                                                                                                            this
                                                                                                                            Agreement,
                                                                                                                            effective
                                                                                                                            immediately;
                                                                                                                            or
                                                                                                                            (ii)
                                                                                                                            if
                                                                                                                            such
                                                                                                                            agreement
                                                                                                                            does
                                                                                                                            not
                                                                                                                            grant
                                                                                                                            or
                                                                                                                            agree
                                                                                                                            to
                                                                                                                            grant
                                                                                                                            a
                                                                                                                            license
                                                                                                                            or
                                                                                                                            sublicense
                                                                                                                            to
                                                                                                                            all
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            IP,
                                                                                                                            to
                                                                                                                            remove
                                                                                                                            from
                                                                                                                            the
                                                                                                                            scope
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            IP
                                                                                                                            licensed
                                                                                                                            or
                                                                                                                            agreed
                                                                                                                            to
                                                                                                                            be
                                                                                                                            licensed
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            such
                                                                                                                            agreement
                                                                                                                            (in
                                                                                                                            which
                                                                                                                            case
                                                                                                                            the
                                                                                                                            Licensed
                                                                                                                            Patents
                                                                                                                            and
                                                                                                                            Licensed
                                                                                                                            Technology
                                                                                                                            licensed
                                                                                                                            or
                                                                                                                            agreed
                                                                                                                            to
                                                                                                                            be
                                                                                                                            licensed
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            such
                                                                                                                            agreement
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            (a) deemed
                                                                                                                            to
                                                                                                                            not
                                                                                                                            be
                                                                                                                            Licensed
                                                                                                                            Patents
                                                                                                                            or
                                                                                                                            Licensed
                                                                                                                            Technology,
                                                                                                                            as
                                                                                                                            applicable,
                                                                                                                            and
                                                                                                                            (b) excluded
                                                                                                                            from
                                                                                                                            the
                                                                                                                            rights
                                                                                                                            granted
                                                                                                                            to
                                                                                                                            Neurotrope
                                                                                                                            under
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            (including
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            Section 2.1))
                                                                                                                            and
                                                                                                                            the
                                                                                                                            Parties
                                                                                                                            shall
                                                                                                                            amend
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            to
                                                                                                                            so
                                                                                                                            reflect
                                                                                                                            such
                                                                                                                            removal.
                                                                                                                            For
                                                                                                                            the
                                                                                                                            avoidance
                                                                                                                            of
                                                                                                                            doubt,
                                                                                                                            any
                                                                                                                            such
                                                                                                                            agreement
                                                                                                                            may
                                                                                                                            grant
                                                                                                                            or
                                                                                                                            agree
                                                                                                                            to
                                                                                                                            grant
                                                                                                                            a
                                                                                                                            license
                                                                                                                            or
                                                                                                                            sublicense
                                                                                                                            to
                                                                                                                            Intellectual
                                                                                                                            Property
                                                                                                                            other
                                                                                                                            than
                                                                                                                            such
                                                                                                                            Licensed
                                                                                                                            Technology
                                                                                                                            and
                                                                                                                            Licensed
                                                                                                                            Patents.
                                                                                                                            BRNI
                                                                                                                            shall
                                                                                                                            give
                                                                                                                            Neurotrope
                                                                                                                            prompt
                                                                                                                            written
                                                                                                                            notice
                                                                                                                            of
                                                                                                                            such
                                                                                                                            termination;
                                                                                                                            provided,
                                                                                                                            however,
                                                                                                                            that
                                                                                                                            any
                                                                                                                            failure
                                                                                                                            to
                                                                                                                            so
                                                                                                                            notify
                                                                                                                            Neurotrope
                                                                                                                            shall
                                                                                                                            not
                                                                                                                            affect
                                                                                                                            such
                                                                                                                            termination.
                                                                                                                            Section
                                                                                                                            22
                                                                                                                            of
                                                                                                                            the
                                                                                                                            Stockholders
                                                                                                                            Agreement
                                                                                                                            shall
                                                                                                                            apply
                                                                                                                            in
                                                                                                                            the
                                                                                                                            event
                                                                                                                            BRNI
                                                                                                                            elects
                                                                                                                            to
                                                                                                                            proceed
                                                                                                                            with
                                                                                                                            clause
                                                                                                                            (i)
                                                                                                                            or
                                                                                                                            clause
                                                                                                                            (ii)
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Section 12.1.

 

		12.2	BRNI’s
                                                                                                                            Reimbursement
                                                                                                                            of
                                                                                                                            Neurotrope’s
                                                                                                                            Broker/Dealer
                                                                                                                            Breakup
                                                                                                                            Fee.
                                                                                                                            If
                                                                                                                            (i)
                                                                                                                            BRNI
                                                                                                                            elects
                                                                                                                            to
                                                                                                                            exercise
                                                                                                                            clause
                                                                                                                            (i)
                                                                                                                            or
                                                                                                                            clause
                                                                                                                            (ii)
                                                                                                                            of
                                                                                                                            Section
                                                                                                                            12.1,
                                                                                                                            (ii) Neurotrope
                                                                                                                            has
                                                                                                                            entered
                                                                                                                            into
                                                                                                                            a
                                                                                                                            written
                                                                                                                            agreement
                                                                                                                            with
                                                                                                                            a
                                                                                                                            licensed
                                                                                                                            broker-dealer
                                                                                                                            or
                                                                                                                            investment
                                                                                                                            bank
                                                                                                                            in
                                                                                                                            connection
                                                                                                                            with
                                                                                                                            the
                                                                                                                            raising
                                                                                                                            of
                                                                                                                            proceeds
                                                                                                                            for
                                                                                                                            the
                                                                                                                            A
                                                                                                                            Round
                                                                                                                            Financing,
                                                                                                                            (iii)
                                                                                                                            BRNI,
                                                                                                                            in
                                                                                                                            its
                                                                                                                            sole
                                                                                                                            discretion,
                                                                                                                            has
                                                                                                                            consented
                                                                                                                            in
                                                                                                                            writing
                                                                                                                            to
                                                                                                                            Neurotrope
                                                                                                                            entering
                                                                                                                            into
                                                                                                                            such
                                                                                                                            agreement
                                                                                                                            prior
                                                                                                                            to
                                                                                                                            Neurotope’s
                                                                                                                            execution
                                                                                                                            of
                                                                                                                            such
                                                                                                                            agreement,
                                                                                                                            and
                                                                                                                            (iv)
                                                                                                                            Neurotrope
                                                                                                                            owes
                                                                                                                            such
                                                                                                                            broker-dealer
                                                                                                                            or
                                                                                                                            investment
                                                                                                                            bank
                                                                                                                            a
                                                                                                                            breakup
                                                                                                                            fee
                                                                                                                            pursuant
                                                                                                                            to
                                                                                                                            such
                                                                                                                            agreement
                                                                                                                            as
                                                                                                                            a
                                                                                                                            result
                                                                                                                            of
                                                                                                                            BRNI’s
                                                                                                                            election
                                                                                                                            to
                                                                                                                            exercise
                                                                                                                            clause
                                                                                                                            (i)
                                                                                                                            or
                                                                                                                            clause
                                                                                                                            (ii)
                                                                                                                            of
                                                                                                                            Section
                                                                                                                            12.1,
                                                                                                                            as
                                                                                                                            applicable,
                                                                                                                            then
                                                                                                                            BRNI
                                                                                                                            shall
                                                                                                                            reimburse
                                                                                                                            Neurotrope
                                                                                                                            for
                                                                                                                            such
                                                                                                                            breakup
                                                                                                                            fee
                                                                                                                            actually
                                                                                                                            paid
                                                                                                                            by
                                                                                                                            Neurotrope
                                                                                                                            to
                                                                                                                            such
                                                                                                                            licensed
                                                                                                                            broker-dealer
                                                                                                                            or
                                                                                                                            investment
                                                                                                                            bank.

 

    	 

    	 

    

 

		13.	Miscellaneous

 

		13.1	Assignment.
                                                                                                                            This
                                                                                                                            Agreement
                                                                                                                            shall
                                                                                                                            bind
                                                                                                                            and
                                                                                                                            inure
                                                                                                                            to
                                                                                                                            the
                                                                                                                            benefit
                                                                                                                            of,
                                                                                                                            and
                                                                                                                            be
                                                                                                                            enforceable
                                                                                                                            by,
                                                                                                                            the
                                                                                                                            Parties
                                                                                                                            and
                                                                                                                            their
                                                                                                                            respective
                                                                                                                            successors
                                                                                                                            and
                                                                                                                            permitted
                                                                                                                            assigns.
                                                                                                                            Neither
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            nor
                                                                                                                            any
                                                                                                                            rights
                                                                                                                            or
                                                                                                                            obligations
                                                                                                                            hereunder
                                                                                                                            may
                                                                                                                            be
                                                                                                                            assigned
                                                                                                                            or
                                                                                                                            transferred
                                                                                                                            (whether
                                                                                                                            by
                                                                                                                            operation
                                                                                                                            of
                                                                                                                            Law
                                                                                                                            or
                                                                                                                            otherwise)
                                                                                                                            by
                                                                                                                            either
                                                                                                                            Party
                                                                                                                            without
                                                                                                                            the
                                                                                                                            other
                                                                                                                            Party’s
                                                                                                                            prior
                                                                                                                            written
                                                                                                                            consent.
                                                                                                                            For
                                                                                                                            the
                                                                                                                            purposes
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Section
                                                                                                                            13.1,
                                                                                                                            any
                                                                                                                            change
                                                                                                                            of
                                                                                                                            control,
                                                                                                                            including
                                                                                                                            sale
                                                                                                                            of
                                                                                                                            stock,
                                                                                                                            merger,
                                                                                                                            consolidation
                                                                                                                            or
                                                                                                                            reorganization
                                                                                                                            of
                                                                                                                            a
                                                                                                                            Party
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            deemed
                                                                                                                            to
                                                                                                                            be
                                                                                                                            an
                                                                                                                            assignment
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement.
                                                                                                                            Any
                                                                                                                            attempted
                                                                                                                            assumption
                                                                                                                            or
                                                                                                                            assignment
                                                                                                                            in
                                                                                                                            contravention
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Section
                                                                                                                            13.1
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            void
                                                                                                                            and
                                                                                                                            ineffective.

 

		13.2	Press
                                                                                                                                   Release.
                                                                                                                                   No
                                                                                                                                   Party
                                                                                                                                   shall
                                                                                                                                   issue
                                                                                                                                   any
                                                                                                                                   press
                                                                                                                                   release
                                                                                                                                   or
                                                                                                                                   use
                                                                                                                                   any
                                                                                                                                   other
                                                                                                                                   Party’s
                                                                                                                                   name,
                                                                                                                                   trademark
                                                                                                                                   or
                                                                                                                                   logos
                                                                                                                                   in
                                                                                                                                   any
                                                                                                                                   external
                                                                                                                                   marketing
                                                                                                                                   or
                                                                                                                                   advertising,
                                                                                                                                   press
                                                                                                                                   release
                                                                                                                                   or
                                                                                                                                   publicity
                                                                                                                                   in
                                                                                                                                   connection
                                                                                                                                   with
                                                                                                                                   this
                                                                                                                                   Agreement
                                                                                                                                   without
                                                                                                                                   such
                                                                                                                                   other
                                                                                                                                   Party’s
                                                                                                                                   prior
                                                                                                                                   written
                                                                                                                                   consent.

 

		13.3	Dispute Resolution. Any Dispute between the Parties shall be resolved as provided in this
Section 13.3.

 

		13.3.1	Informal Dispute Resolution. The Parties shall use commercially reasonable efforts to resolve
any Dispute hereunder in the first instance utilizing the Dispute Resolution Procedures set forth in this Section 13.3.1.
In the event of any Dispute between the Parties, each Party may initiate the Dispute Resolution Procedure by providing notice of
the Dispute to the other Party. The Parties shall attempt to resolve any Dispute arising under this Agreement in good faith utilizing
in the first instance each Party’s manager with primary responsibility for the SOW under which the Dispute arose. Prior to
initiating any lawsuit, each Party shall escalate such Dispute to successively more senior-levels of executive. Each Party shall
use commercially reasonable efforts to make such senior management or executives available to speak with (including by telephone)
his or her counterpart upon reasonable notice and at a reasonable time.

 

		13.3.2	Formal Proceedings. Formal proceedings for the resolution of a Dispute may be commenced
after the earlier of: (i) the exhaustion of the Dispute Resolution Procedure as set forth in Section 13.3.1; and (ii) ninety
(90) days after the initial request to negotiate the Dispute. Notwithstanding the foregoing, each Party may institute formal proceedings
at any time in order to avoid the expiration of any applicable limitations period, to preserve a superior position with respect
to other creditors, or to seek equitable relief.

 

		13.4	Choice
                                                                                                                                   of
                                                                                                                                   Law.
                                                                                                                                   This
                                                                                                                                   Agreement
                                                                                                                                   shall
                                                                                                                                   be
                                                                                                                                   governed
                                                                                                                                   by,
                                                                                                                                   and
                                                                                                                                   enforced
                                                                                                                                   and
                                                                                                                                   construed
                                                                                                                                   in
                                                                                                                                   accordance
                                                                                                                                   with,
                                                                                                                                   the
                                                                                                                                   Laws
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   State
                                                                                                                                   of
                                                                                                                                   Delaware
                                                                                                                                   without
                                                                                                                                   giving
                                                                                                                                   effect
                                                                                                                                   to
                                                                                                                                   any
                                                                                                                                   choice
                                                                                                                                   of
                                                                                                                                   Law
                                                                                                                                   or
                                                                                                                                   conflict
                                                                                                                                   of
                                                                                                                                   Law
                                                                                                                                   rules
                                                                                                                                   or
                                                                                                                                   provisions
                                                                                                                                   (whether
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   State
                                                                                                                                   of
                                                                                                                                   Delaware
                                                                                                                                   or
                                                                                                                                   any
                                                                                                                                   other
                                                                                                                                   jurisdiction)
                                                                                                                                   that
                                                                                                                                   would
                                                                                                                                   cause
                                                                                                                                   the
                                                                                                                                   application
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   laws
                                                                                                                                   of
                                                                                                                                   any
                                                                                                                                   jurisdiction
                                                                                                                                   other
                                                                                                                                   than
                                                                                                                                   the
                                                                                                                                   State
                                                                                                                                   of
                                                                                                                                   Delaware.

 

		13.5	Jurisdiction
                                                                                                                                   and
                                                                                                                                   Venue.
                                                                                                                                   Each
                                                                                                                                   Party
                                                                                                                                   hereby
                                                                                                                                   irrevocably
                                                                                                                                   submits
                                                                                                                                   to
                                                                                                                                   the
                                                                                                                                   exclusive
                                                                                                                                   jurisdiction
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   courts
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   United
                                                                                                                                   States
                                                                                                                                   of
                                                                                                                                   America
                                                                                                                                   located
                                                                                                                                   in
                                                                                                                                   the
                                                                                                                                   State
                                                                                                                                   of
                                                                                                                                   Delaware,
                                                                                                                                   for
                                                                                                                                   the
                                                                                                                                   purposes
                                                                                                                                   of
                                                                                                                                   any
                                                                                                                                   Action
                                                                                                                                   arising
                                                                                                                                   out
                                                                                                                                   of
                                                                                                                                   this
                                                                                                                                   Agreement.
                                                                                                                                   Each
                                                                                                                                   Party
                                                                                                                                   agrees
                                                                                                                                   that
                                                                                                                                   service
                                                                                                                                   of
                                                                                                                                   any
                                                                                                                                   process,
                                                                                                                                   summons,
                                                                                                                                   notice,
                                                                                                                                   or
                                                                                                                                   document
                                                                                                                                   by
                                                                                                                                   personal
                                                                                                                                   delivery,
                                                                                                                                   by
                                                                                                                                   registered
                                                                                                                                   mail,
                                                                                                                                   or
                                                                                                                                   by
                                                                                                                                   a
                                                                                                                                   recognized
                                                                                                                                   international
                                                                                                                                   express
                                                                                                                                   delivery
                                                                                                                                   service
                                                                                                                                   to
                                                                                                                                   such
                                                                                                                                   Party’s
                                                                                                                                   respective
                                                                                                                                   address
                                                                                                                                   set
                                                                                                                                   forth
                                                                                                                                   in
                                                                                                                                   Section
                                                                                                                                   13.13
                                                                                                                                   (as
                                                                                                                                   such
                                                                                                                                   address
                                                                                                                                   may
                                                                                                                                   be
                                                                                                                                   changed
                                                                                                                                   by
                                                                                                                                   notice
                                                                                                                                   delivered
                                                                                                                                   pursuant
                                                                                                                                   to
                                                                                                                                   such
                                                                                                                                   section)
                                                                                                                                   shall
                                                                                                                                   be
                                                                                                                                   effective
                                                                                                                                   service
                                                                                                                                   of
                                                                                                                                   process
                                                                                                                                   for
                                                                                                                                   any
                                                                                                                                   Action
                                                                                                                                   in
                                                                                                                                   the
                                                                                                                                   applicable
                                                                                                                                   court
                                                                                                                                   with
                                                                                                                                   respect
                                                                                                                                   to
                                                                                                                                   any
                                                                                                                                   matters
                                                                                                                                   to
                                                                                                                                   which
                                                                                                                                   it
                                                                                                                                   has
                                                                                                                                   submitted
                                                                                                                                   to
                                                                                                                                   jurisdiction
                                                                                                                                   in
                                                                                                                                   this
                                                                                                                                   Section
                                                                                                                                   13.5.
                                                                                                                                   Each
                                                                                                                                   Party
                                                                                                                                   irrevocably
                                                                                                                                   and
                                                                                                                                   unconditionally
                                                                                                                                   waives
                                                                                                                                   any
                                                                                                                                   objection
                                                                                                                                   to
                                                                                                                                   the
                                                                                                                                   laying
                                                                                                                                   of
                                                                                                                                   venue
                                                                                                                                   of
                                                                                                                                   any
                                                                                                                                   Action
                                                                                                                                   arising
                                                                                                                                   out
                                                                                                                                   of
                                                                                                                                   this
                                                                                                                                   Agreement
                                                                                                                                   in
                                                                                                                                   such
                                                                                                                                   court,
                                                                                                                                   and
                                                                                                                                   hereby
                                                                                                                                   and
                                                                                                                                   thereby
                                                                                                                                   further
                                                                                                                                   irrevocably
                                                                                                                                   and
                                                                                                                                   unconditionally
                                                                                                                                   waives
                                                                                                                                   and
                                                                                                                                   agrees
                                                                                                                                   not
                                                                                                                                   to
                                                                                                                                   plead
                                                                                                                                   or
                                                                                                                                   claim
                                                                                                                                   in
                                                                                                                                   any
                                                                                                                                   such
                                                                                                                                   court
                                                                                                                                   that
                                                                                                                                   any
                                                                                                                                   such
                                                                                                                                   Action
                                                                                                                                   brought
                                                                                                                                   in
                                                                                                                                   any
                                                                                                                                   such
                                                                                                                                   court
                                                                                                                                   has
                                                                                                                                   been
                                                                                                                                   brought
                                                                                                                                   in
                                                                                                                                   an
                                                                                                                                   inconvenient
                                                                                                                                   forum.

 

    	 

    	 

    

 

		13.6	Construction.
                                                                                                                            The
                                                                                                                            definitions
                                                                                                                            of
                                                                                                                            the
                                                                                                                            terms
                                                                                                                            herein
                                                                                                                            shall
                                                                                                                            apply
                                                                                                                            equally
                                                                                                                            to
                                                                                                                            the
                                                                                                                            singular
                                                                                                                            and
                                                                                                                            plural
                                                                                                                            forms
                                                                                                                            of
                                                                                                                            the
                                                                                                                            terms
                                                                                                                            defined.
                                                                                                                            Any
                                                                                                                            reference
                                                                                                                            to
                                                                                                                            the
                                                                                                                            masculine,
                                                                                                                            feminine
                                                                                                                            or
                                                                                                                            neuter
                                                                                                                            gender
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            deemed
                                                                                                                            to
                                                                                                                            include
                                                                                                                            any
                                                                                                                            gender
                                                                                                                            or
                                                                                                                            all
                                                                                                                            three
                                                                                                                            as
                                                                                                                            appropriate.
                                                                                                                            The
                                                                                                                            words
                                                                                                                            “include,”
                                                                                                                            “includes,”
                                                                                                                            and
                                                                                                                            “including”
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            deemed
                                                                                                                            to
                                                                                                                            be
                                                                                                                            followed
                                                                                                                            by
                                                                                                                            the
                                                                                                                            phrase
                                                                                                                            “without
                                                                                                                            limitation.”
                                                                                                                            The
                                                                                                                            word
                                                                                                                            “will”
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            construed
                                                                                                                            to
                                                                                                                            have
                                                                                                                            the
                                                                                                                            same
                                                                                                                            meaning
                                                                                                                            and
                                                                                                                            effect
                                                                                                                            as
                                                                                                                            the
                                                                                                                            word
                                                                                                                            “shall”
                                                                                                                            and
                                                                                                                            vice
                                                                                                                            versa.
                                                                                                                            The
                                                                                                                            word
                                                                                                                            “or”
                                                                                                                            in
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            is
                                                                                                                            disjunctive
                                                                                                                            but
                                                                                                                            not
                                                                                                                            necessarily
                                                                                                                            exclusive.
                                                                                                                            The
                                                                                                                            Parties
                                                                                                                            have
                                                                                                                            participated
                                                                                                                            jointly
                                                                                                                            in
                                                                                                                            the
                                                                                                                            negotiation
                                                                                                                            and
                                                                                                                            drafting
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement.
                                                                                                                            In
                                                                                                                            the
                                                                                                                            event
                                                                                                                            an
                                                                                                                            ambiguity
                                                                                                                            or
                                                                                                                            question
                                                                                                                            of
                                                                                                                            intent
                                                                                                                            or
                                                                                                                            interpretation
                                                                                                                            arises,
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            construed
                                                                                                                            as
                                                                                                                            if
                                                                                                                            drafted
                                                                                                                            jointly
                                                                                                                            by
                                                                                                                            the
                                                                                                                            Parties,
                                                                                                                            and
                                                                                                                            no
                                                                                                                            presumption
                                                                                                                            or
                                                                                                                            burden
                                                                                                                            of
                                                                                                                            proof
                                                                                                                            shall
                                                                                                                            arise
                                                                                                                            favoring
                                                                                                                            or
                                                                                                                            disfavoring
                                                                                                                            any
                                                                                                                            Party
                                                                                                                            by
                                                                                                                            virtue
                                                                                                                            of
                                                                                                                            the
                                                                                                                            authorship
                                                                                                                            of
                                                                                                                            any
                                                                                                                            of
                                                                                                                            the
                                                                                                                            provisions
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement.
                                                                                                                            The
                                                                                                                            Parties
                                                                                                                            hereto
                                                                                                                            intend
                                                                                                                            that
                                                                                                                            each
                                                                                                                            covenant
                                                                                                                            and
                                                                                                                            agreement
                                                                                                                            contained
                                                                                                                            herein
                                                                                                                            shall
                                                                                                                            have
                                                                                                                            independent
                                                                                                                            significance.
                                                                                                                            If
                                                                                                                            either
                                                                                                                            Party
                                                                                                                            has
                                                                                                                            breached
                                                                                                                            any
                                                                                                                            covenant
                                                                                                                            or
                                                                                                                            agreement
                                                                                                                            contained
                                                                                                                            herein
                                                                                                                            in
                                                                                                                            any
                                                                                                                            respect,
                                                                                                                            the
                                                                                                                            fact
                                                                                                                            that
                                                                                                                            there
                                                                                                                            exists
                                                                                                                            another
                                                                                                                            covenant
                                                                                                                            or
                                                                                                                            agreement
                                                                                                                            relating
                                                                                                                            to
                                                                                                                            the
                                                                                                                            same
                                                                                                                            subject
                                                                                                                            matter
                                                                                                                            (regardless
                                                                                                                            of
                                                                                                                            the
                                                                                                                            relative
                                                                                                                            levels
                                                                                                                            of
                                                                                                                            specificity)
                                                                                                                            which
                                                                                                                            such
                                                                                                                            Party
                                                                                                                            has
                                                                                                                            not
                                                                                                                            breached
                                                                                                                            shall
                                                                                                                            not
                                                                                                                            detract
                                                                                                                            from
                                                                                                                            or
                                                                                                                            mitigate
                                                                                                                            the
                                                                                                                            fact
                                                                                                                            that
                                                                                                                            such
                                                                                                                            Party
                                                                                                                            is
                                                                                                                            in
                                                                                                                            breach
                                                                                                                            of
                                                                                                                            the
                                                                                                                            first
                                                                                                                            covenant
                                                                                                                            or
                                                                                                                            agreement.
                                                                                                                            Unless
                                                                                                                            the
                                                                                                                            context
                                                                                                                            requires
                                                                                                                            otherwise:
                                                                                                                            (i)
                                                                                                                            any
                                                                                                                            definition
                                                                                                                            of
                                                                                                                            or
                                                                                                                            reference
                                                                                                                            to
                                                                                                                            any
                                                                                                                            agreement
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            construed
                                                                                                                            as
                                                                                                                            referring
                                                                                                                            to
                                                                                                                            such
                                                                                                                            agreement
                                                                                                                            as
                                                                                                                            from
                                                                                                                            time
                                                                                                                            to
                                                                                                                            time
                                                                                                                            amended,
                                                                                                                            supplemented
                                                                                                                            or
                                                                                                                            otherwise
                                                                                                                            modified;
                                                                                                                            (ii)
                                                                                                                            any
                                                                                                                            reference
                                                                                                                            to
                                                                                                                            any
                                                                                                                            Laws
                                                                                                                            herein
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            construed
                                                                                                                            as
                                                                                                                            referring
                                                                                                                            to
                                                                                                                            such
                                                                                                                            Laws
                                                                                                                            as
                                                                                                                            from
                                                                                                                            time
                                                                                                                            to
                                                                                                                            time
                                                                                                                            enacted,
                                                                                                                            repealed
                                                                                                                            or
                                                                                                                            amended;
                                                                                                                            (iii)
                                                                                                                            any
                                                                                                                            reference
                                                                                                                            herein
                                                                                                                            to
                                                                                                                            any
                                                                                                                            Person
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            construed
                                                                                                                            to
                                                                                                                            include
                                                                                                                            the
                                                                                                                            Person’s
                                                                                                                            permitted
                                                                                                                            successors
                                                                                                                            and
                                                                                                                            assigns;
                                                                                                                            (iv)
                                                                                                                            the
                                                                                                                            words
                                                                                                                            “herein,”
                                                                                                                            “hereof,”
                                                                                                                            and
                                                                                                                            “hereunder,”
                                                                                                                            and
                                                                                                                            words
                                                                                                                            of
                                                                                                                            similar
                                                                                                                            import,
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            construed
                                                                                                                            to
                                                                                                                            refer
                                                                                                                            to
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            in
                                                                                                                            its
                                                                                                                            entirety
                                                                                                                            and
                                                                                                                            not
                                                                                                                            to
                                                                                                                            any
                                                                                                                            particular
                                                                                                                            provision
                                                                                                                            hereof;
                                                                                                                            and
                                                                                                                            (v)
                                                                                                                            all
                                                                                                                            references
                                                                                                                            herein
                                                                                                                            to
                                                                                                                            Articles,
                                                                                                                            Sections
                                                                                                                            or
                                                                                                                            Exhibits,
                                                                                                                            unless
                                                                                                                            otherwise
                                                                                                                            specifically
                                                                                                                            provided,
                                                                                                                            shall
                                                                                                                            be
                                                                                                                            construed
                                                                                                                            to
                                                                                                                            refer
                                                                                                                            to
                                                                                                                            Articles,
                                                                                                                            Sections
                                                                                                                            and
                                                                                                                            Exhibits
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement.

 

		13.7	Counterparts.
                                                                                                                            This
                                                                                                                            Agreement
                                                                                                                            may
                                                                                                                            be
                                                                                                                            executed
                                                                                                                            simultaneously
                                                                                                                            in
                                                                                                                            two
                                                                                                                            or
                                                                                                                            more
                                                                                                                            counterparts
                                                                                                                            (including
                                                                                                                            by
                                                                                                                            means
                                                                                                                            of
                                                                                                                            facsimile
                                                                                                                            or
                                                                                                                            electronic
                                                                                                                            transmission
                                                                                                                            in
                                                                                                                            portable
                                                                                                                            document
                                                                                                                            format
                                                                                                                            (pdf)),
                                                                                                                            any
                                                                                                                            one
                                                                                                                            of
                                                                                                                            which
                                                                                                                            need
                                                                                                                            not
                                                                                                                            contain
                                                                                                                            the
                                                                                                                            signatures
                                                                                                                            of
                                                                                                                            more
                                                                                                                            than
                                                                                                                            one
                                                                                                                            Party,
                                                                                                                            but
                                                                                                                            all
                                                                                                                            such
                                                                                                                            counterparts
                                                                                                                            taken
                                                                                                                            together
                                                                                                                            shall
                                                                                                                            constitute
                                                                                                                            one
                                                                                                                            and
                                                                                                                            the
                                                                                                                            same
                                                                                                                            Agreement.

 

		13.8	Entire
                                                                                                                            Agreement.
                                                                                                                            This
                                                                                                                            Agreement
                                                                                                                            (together
                                                                                                                            with
                                                                                                                            any
                                                                                                                            SOWs
                                                                                                                            executed
                                                                                                                            by
                                                                                                                            BRNI
                                                                                                                            and
                                                                                                                            Neurotrope
                                                                                                                            hereunder)
                                                                                                                            constitutes
                                                                                                                            the
                                                                                                                            entire
                                                                                                                            agreement
                                                                                                                            among
                                                                                                                            the
                                                                                                                            Parties
                                                                                                                            as
                                                                                                                            to
                                                                                                                            the
                                                                                                                            subject
                                                                                                                            matter
                                                                                                                            of
                                                                                                                            this
                                                                                                                            Agreement
                                                                                                                            and
                                                                                                                            supersedes
                                                                                                                            and
                                                                                                                            merges
                                                                                                                            all
                                                                                                                            prior
                                                                                                                            negotiations,
                                                                                                                            representations,
                                                                                                                            agreements,
                                                                                                                            and
                                                                                                                            understandings
                                                                                                                            regarding
                                                                                                                            the
                                                                                                                            same.

 

    	 

    	 

    

 

		13.9	Order
                                                                                                                                   of
                                                                                                                                   Precedence.
                                                                                                                                   In
                                                                                                                                   case
                                                                                                                                   of
                                                                                                                                   ambiguity
                                                                                                                                   or
                                                                                                                                   conflict
                                                                                                                                   between
                                                                                                                                   the
                                                                                                                                   terms
                                                                                                                                   and
                                                                                                                                   conditions
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   body
                                                                                                                                   of
                                                                                                                                   this
                                                                                                                                   Agreement,
                                                                                                                                   on
                                                                                                                                   the
                                                                                                                                   one
                                                                                                                                   hand,
                                                                                                                                   and
                                                                                                                                   an
                                                                                                                                   SOW,
                                                                                                                                   on
                                                                                                                                   the
                                                                                                                                   other
                                                                                                                                   hand,
                                                                                                                                   the
                                                                                                                                   terms
                                                                                                                                   and
                                                                                                                                   conditions
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   body
                                                                                                                                   of
                                                                                                                                   this
                                                                                                                                   Agreement
                                                                                                                                   shall
                                                                                                                                   control,
                                                                                                                                   except
                                                                                                                                   that
                                                                                                                                   when
                                                                                                                                   an
                                                                                                                                   SOW
                                                                                                                                   expressly
                                                                                                                                   references
                                                                                                                                   a
                                                                                                                                   term
                                                                                                                                   or
                                                                                                                                   condition
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   body
                                                                                                                                   of
                                                                                                                                   this
                                                                                                                                   Agreement
                                                                                                                                   and
                                                                                                                                   expressly
                                                                                                                                   states
                                                                                                                                   the
                                                                                                                                   intent
                                                                                                                                   of
                                                                                                                                   the
                                                                                                                                   Parties
                                                                                                                                   to
                                                                                                                                   override
                                                                                                                                   such
                                                                                                                                   term
                                                                                                                                   or
                                                                                                                                   condition,
                                                                                                                                   the
                                                                                                                                   applicable
                                                                                                                                   term
                                                                                                                                   or
                                                                                                                                   condition
                                                                                                                                   of
                                                                                                                                   such
                                                                                                                                   SOW
                                                                                                                                   shall
                                                                                                                                   control
                                                                                                                                   for
                                                                                                                                   purposes
                                                                                                                                   of
                                                                                                                                   that
                                                                                                                                   particular
                                                                                                                                   SOW.

 

		13.10	Force
                                                                                                                             Majeure.
                                                                                                                             No
                                                                                                                             Party
                                                                                                                             shall
                                                                                                                             be
                                                                                                                             liable
                                                                                                                             for
                                                                                                                             delay
                                                                                                                             or
                                                                                                                             failure
                                                                                                                             in
                                                                                                                             the
                                                                                                                             performance
                                                                                                                             of
                                                                                                                             any
                                                                                                                             of
                                                                                                                             its
                                                                                                                             obligations
                                                                                                                             hereunder
                                                                                                                             (other
                                                                                                                             than
                                                                                                                             obligations
                                                                                                                             with
                                                                                                                             respect
                                                                                                                             to
                                                                                                                             payment)
                                                                                                                             if
                                                                                                                             such
                                                                                                                             delay
                                                                                                                             or
                                                                                                                             failure
                                                                                                                             is
                                                                                                                             due
                                                                                                                             to
                                                                                                                             a
                                                                                                                             Force
                                                                                                                             Majeure
                                                                                                                             Event;
                                                                                                                             provided,
                                                                                                                             however,
                                                                                                                             that
                                                                                                                             the
                                                                                                                             affected
                                                                                                                             Party
                                                                                                                             promptly
                                                                                                                             notifies
                                                                                                                             the
                                                                                                                             other
                                                                                                                             Party
                                                                                                                             in
                                                                                                                             writing
                                                                                                                             and
                                                                                                                             further
                                                                                                                             provided
                                                                                                                             that
                                                                                                                             the
                                                                                                                             affected
                                                                                                                             Party
                                                                                                                             shall
                                                                                                                             use
                                                                                                                             its
                                                                                                                             commercially
                                                                                                                             reasonable
                                                                                                                             efforts
                                                                                                                             to
                                                                                                                             avoid
                                                                                                                             or
                                                                                                                             remove
                                                                                                                             such
                                                                                                                             causes
                                                                                                                             of
                                                                                                                             delay
                                                                                                                             or
                                                                                                                             failure
                                                                                                                             and
                                                                                                                             to
                                                                                                                             mitigate
                                                                                                                             the
                                                                                                                             effect
                                                                                                                             of
                                                                                                                             such
                                                                                                                             delay
                                                                                                                             or
                                                                                                                             failure,
                                                                                                                             and
                                                                                                                             shall
                                                                                                                             continue
                                                                                                                             performance
                                                                                                                             with
                                                                                                                             reasonable
                                                                                                                             dispatch
                                                                                                                             whenever
                                                                                                                             such
                                                                                                                             causes
                                                                                                                             are
                                                                                                                             removed.

 

		13.11	Further
                                                                                                                                    Assurances.
                                                                                                                                    Each
                                                                                                                                    Party
                                                                                                                                    shall
                                                                                                                                    do
                                                                                                                                    and
                                                                                                                                    perform
                                                                                                                                    all
                                                                                                                                    such
                                                                                                                                    further
                                                                                                                                    acts
                                                                                                                                    and
                                                                                                                                    things
                                                                                                                                    and
                                                                                                                                    shall
                                                                                                                                    execute
                                                                                                                                    and
                                                                                                                                    deliver
                                                                                                                                    such
                                                                                                                                    other
                                                                                                                                    agreements,
                                                                                                                                    certificates,
                                                                                                                                    instruments,
                                                                                                                                    and
                                                                                                                                    documents
                                                                                                                                    necessary
                                                                                                                                    or
                                                                                                                                    that
                                                                                                                                    the
                                                                                                                                    other
                                                                                                                                    Party
                                                                                                                                    may
                                                                                                                                    deem
                                                                                                                                    advisable
                                                                                                                                    in
                                                                                                                                    order
                                                                                                                                    to
                                                                                                                                    carry
                                                                                                                                    out
                                                                                                                                    the
                                                                                                                                    intent
                                                                                                                                    and
                                                                                                                                    accomplish
                                                                                                                                    the
                                                                                                                                    purposes
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    and
                                                                                                                                    to
                                                                                                                                    evidence,
                                                                                                                                    perfect,
                                                                                                                                    or
                                                                                                                                    otherwise
                                                                                                                                    confirm
                                                                                                                                    its
                                                                                                                                    rights
                                                                                                                                    hereunder
                                                                                                                                    (including,
                                                                                                                                    with
                                                                                                                                    respect
                                                                                                                                    to
                                                                                                                                    Neurotrope,
                                                                                                                                    to
                                                                                                                                    confirm
                                                                                                                                    BRNI’s
                                                                                                                                    ownership
                                                                                                                                    of
                                                                                                                                    the
                                                                                                                                    Licensed
                                                                                                                                    IP
                                                                                                                                    (including
                                                                                                                                    by
                                                                                                                                    the
                                                                                                                                    execution
                                                                                                                                    and
                                                                                                                                    delivery
                                                                                                                                    of
                                                                                                                                    any
                                                                                                                                    and
                                                                                                                                    all
                                                                                                                                    affidavits,
                                                                                                                                    declarations,
                                                                                                                                    oaths,
                                                                                                                                    samples,
                                                                                                                                    exhibits,
                                                                                                                                    specimens,
                                                                                                                                    assignments,
                                                                                                                                    powers
                                                                                                                                    of
                                                                                                                                    attorney
                                                                                                                                    and
                                                                                                                                    other
                                                                                                                                    documentation)
                                                                                                                                    and
                                                                                                                                    to
                                                                                                                                    assist
                                                                                                                                    a
                                                                                                                                    Party
                                                                                                                                    in
                                                                                                                                    prosecuting,
                                                                                                                                    maintain
                                                                                                                                    and
                                                                                                                                    enforcing
                                                                                                                                    the
                                                                                                                                    Licensed
                                                                                                                                    IP).

 

		13.12	Headings.
                                                                                                                                    The
                                                                                                                                    headings
                                                                                                                                    and
                                                                                                                                    captions
                                                                                                                                    used
                                                                                                                                    in
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    are
                                                                                                                                    for
                                                                                                                                    reference
                                                                                                                                    purposes
                                                                                                                                    only
                                                                                                                                    and
                                                                                                                                    shall
                                                                                                                                    not
                                                                                                                                    affect
                                                                                                                                    in
                                                                                                                                    any
                                                                                                                                    way
                                                                                                                                    the
                                                                                                                                    meaning
                                                                                                                                    or
                                                                                                                                    interpretation
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement.

 

		13.13	Notices.
                                                                                                                                    All
                                                                                                                                    notices,
                                                                                                                                    demands
                                                                                                                                    or
                                                                                                                                    other
                                                                                                                                    communications
                                                                                                                                    to
                                                                                                                                    be
                                                                                                                                    given
                                                                                                                                    or
                                                                                                                                    delivered
                                                                                                                                    under
                                                                                                                                    or
                                                                                                                                    by
                                                                                                                                    reason
                                                                                                                                    of
                                                                                                                                    the
                                                                                                                                    provisions
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    shall
                                                                                                                                    be
                                                                                                                                    in
                                                                                                                                    writing
                                                                                                                                    and
                                                                                                                                    shall
                                                                                                                                    be
                                                                                                                                    deemed
                                                                                                                                    to
                                                                                                                                    have
                                                                                                                                    been
                                                                                                                                    given
                                                                                                                                    only:
                                                                                                                                    (i)
                                                                                                                                    when
                                                                                                                                    delivered
                                                                                                                                    personally
                                                                                                                                    to
                                                                                                                                    the
                                                                                                                                    recipient;
                                                                                                                                    (ii)
                                                                                                                                    one
                                                                                                                                    (1)
                                                                                                                                    business
                                                                                                                                    day
                                                                                                                                    after
                                                                                                                                    being
                                                                                                                                    sent
                                                                                                                                    to
                                                                                                                                    the
                                                                                                                                    recipient
                                                                                                                                    by
                                                                                                                                    reputable
                                                                                                                                    overnight
                                                                                                                                    courier
                                                                                                                                    service
                                                                                                                                    (charges
                                                                                                                                    prepaid)
                                                                                                                                    provided
                                                                                                                                    that
                                                                                                                                    confirmation
                                                                                                                                    of
                                                                                                                                    delivery
                                                                                                                                    is
                                                                                                                                    received;
                                                                                                                                    (iii)
                                                                                                                                    upon
                                                                                                                                    machine
                                                                                                                                    generated
                                                                                                                                    acknowledgment
                                                                                                                                    of
                                                                                                                                    receipt
                                                                                                                                    after
                                                                                                                                    transmittal
                                                                                                                                    by
                                                                                                                                    facsimile
                                                                                                                                    (provided
                                                                                                                                    that
                                                                                                                                    a
                                                                                                                                    confirmation
                                                                                                                                    copy
                                                                                                                                    is
                                                                                                                                    sent
                                                                                                                                    via
                                                                                                                                    reputable
                                                                                                                                    overnight
                                                                                                                                    courier
                                                                                                                                    service
                                                                                                                                    for
                                                                                                                                    delivery
                                                                                                                                    within
                                                                                                                                    two
                                                                                                                                    (2)
                                                                                                                                    business
                                                                                                                                    days
                                                                                                                                    thereafter);
                                                                                                                                    or
                                                                                                                                    (iv)
                                                                                                                                    five
                                                                                                                                    (5)
                                                                                                                                    after
                                                                                                                                    being
                                                                                                                                    mailed
                                                                                                                                    to
                                                                                                                                    the
                                                                                                                                    recipient
                                                                                                                                    by
                                                                                                                                    certified
                                                                                                                                    or
                                                                                                                                    registered
                                                                                                                                    mail
                                                                                                                                    (return
                                                                                                                                    receipt
                                                                                                                                    requested
                                                                                                                                    and
                                                                                                                                    postage
                                                                                                                                    prepaid).
                                                                                                                                    Such
                                                                                                                                    notices,
                                                                                                                                    demands
                                                                                                                                    and
                                                                                                                                    other
                                                                                                                                    communications
                                                                                                                                    shall
                                                                                                                                    be
                                                                                                                                    sent
                                                                                                                                    to
                                                                                                                                    the
                                                                                                                                    persons
                                                                                                                                    and
                                                                                                                                    addresses
                                                                                                                                    indicated
                                                                                                                                    below:

 

    	 

    	 

    

 

If to BRNI:

 

	Blanchette Rockefeller Neurosciences Institute
	Address:	8 Medical Center Drive
	 	Morgantown, WV 26505-3409
	Attention:	Shana Phares
	 	Chief Executive Officer
	Telephone:	304-293-1361
	Facsimile:	304-293-7536

 

With a copy to (which shall not constitute
notice):

 

	Address:	Steptoe & Johnson
	 	P.O. Box 1616
	 	Morgantown, WV 26507-1616
	Attention:	Tom Vorbach
	Telephone:	304-598-8112
	Facsimile:	304-598-8116

 

If to NRV II:

 

	NRV II, LLC c/o Neuroscience Research Ventures, Inc.
	Address:	364 Patteson Drive, #729
	 	Morgantown, WV 26505
	Attention:	Tom Vorbach
	 	Assistant Secretary
	Telephone:	304-598-8112
	Facsimile:	304-598-8116

 

With a copy to (which shall not constitute
notice):

 

	Address:	Steptoe & Johnson
	 	P.O. Box 1616
	 	Morgantown, WV 26507-1616
	Attention:	Tom Vorbach
	Telephone:	304-598-8112
	Facsimile:	304-598-8116

 

If to Neurotrope:

 

	Neurotrope BioScience, Inc.
	Address:	10732 Hawk’s Vista St.
	 	Plantation, Florida 33324
	Attention:	Chief Executive Officer
	 	Jim New
	Telephone:	954-452-4656
	Facsimile:	954-452-4656

 

    	 

    	 

    

 

or to such other address or to
the attention of such other individual person as the recipient Party has specified by prior written notice to the sending Party.

 

		13.14	Relationship
                                                                                                                             of
                                                                                                                             the
                                                                                                                             Parties.
                                                                                                                             Each
                                                                                                                             Party
                                                                                                                             is
                                                                                                                             an
                                                                                                                             independent
                                                                                                                             contractor
                                                                                                                             under
                                                                                                                             this
                                                                                                                             Agreement.
                                                                                                                             Nothing
                                                                                                                             contained
                                                                                                                             herein
                                                                                                                             is
                                                                                                                             intended
                                                                                                                             or
                                                                                                                             is
                                                                                                                             to
                                                                                                                             be
                                                                                                                             construed
                                                                                                                             so
                                                                                                                             as
                                                                                                                             to
                                                                                                                             constitute
                                                                                                                             either
                                                                                                                             Party
                                                                                                                             as
                                                                                                                             an
                                                                                                                             agent
                                                                                                                             of
                                                                                                                             the
                                                                                                                             other
                                                                                                                             Party.
                                                                                                                             Nothing
                                                                                                                             in
                                                                                                                             this
                                                                                                                             Agreement
                                                                                                                             shall
                                                                                                                             be
                                                                                                                             construed
                                                                                                                             to
                                                                                                                             create:
                                                                                                                             (i)
                                                                                                                             a
                                                                                                                             partnership,
                                                                                                                             joint
                                                                                                                             venture
                                                                                                                             or
                                                                                                                             other
                                                                                                                             joint
                                                                                                                             business
                                                                                                                             arrangement
                                                                                                                             between
                                                                                                                             the
                                                                                                                             Parties;
                                                                                                                             (ii)
                                                                                                                             any
                                                                                                                             fiduciary
                                                                                                                             duty
                                                                                                                             owed
                                                                                                                             by
                                                                                                                             a
                                                                                                                             Party
                                                                                                                             to
                                                                                                                             the
                                                                                                                             other
                                                                                                                             Party
                                                                                                                             or
                                                                                                                             any
                                                                                                                             of
                                                                                                                             its
                                                                                                                             Affiliates;
                                                                                                                             or
                                                                                                                             (iii)
                                                                                                                             a
                                                                                                                             relationship
                                                                                                                             of
                                                                                                                             employer
                                                                                                                             and
                                                                                                                             employee
                                                                                                                             between
                                                                                                                             or
                                                                                                                             among
                                                                                                                             any
                                                                                                                             of
                                                                                                                             the
                                                                                                                             Parties
                                                                                                                             or
                                                                                                                             their
                                                                                                                             respective
                                                                                                                             Affiliates.
                                                                                                                             The
                                                                                                                             Parties
                                                                                                                             are
                                                                                                                             not
                                                                                                                             joint
                                                                                                                             employers,
                                                                                                                             a
                                                                                                                             single
                                                                                                                             employer,
                                                                                                                             associated
                                                                                                                             employers
                                                                                                                             or
                                                                                                                             related
                                                                                                                             employers
                                                                                                                             for
                                                                                                                             any
                                                                                                                             purpose
                                                                                                                             under
                                                                                                                             this
                                                                                                                             Agreement.
                                                                                                                             Neither
                                                                                                                             Party
                                                                                                                             shall
                                                                                                                             have
                                                                                                                             the
                                                                                                                             authority
                                                                                                                             to
                                                                                                                             commit
                                                                                                                             the
                                                                                                                             other
                                                                                                                             Party
                                                                                                                             contractually
                                                                                                                             or
                                                                                                                             otherwise
                                                                                                                             to
                                                                                                                             any
                                                                                                                             obligations
                                                                                                                             to
                                                                                                                             any
                                                                                                                             Third
                                                                                                                             Party.

 

		13.15	Severability.
                                                                                                                             Whenever
                                                                                                                             possible,
                                                                                                                             each
                                                                                                                             provision
                                                                                                                             of
                                                                                                                             this
                                                                                                                             Agreement
                                                                                                                             shall
                                                                                                                             be
                                                                                                                             interpreted
                                                                                                                             in
                                                                                                                             such
                                                                                                                             manner
                                                                                                                             as
                                                                                                                             to
                                                                                                                             be
                                                                                                                             effective
                                                                                                                             and
                                                                                                                             valid
                                                                                                                             under
                                                                                                                             applicable
                                                                                                                             Law,
                                                                                                                             but
                                                                                                                             if
                                                                                                                             any
                                                                                                                             provision
                                                                                                                             of
                                                                                                                             this
                                                                                                                             Agreement
                                                                                                                             is
                                                                                                                             held
                                                                                                                             to
                                                                                                                             be
                                                                                                                             invalid,
                                                                                                                             illegal
                                                                                                                             or
                                                                                                                             unenforceable
                                                                                                                             in
                                                                                                                             any
                                                                                                                             respect
                                                                                                                             under
                                                                                                                             any
                                                                                                                             applicable
                                                                                                                             Law
                                                                                                                             in
                                                                                                                             any
                                                                                                                             jurisdiction,
                                                                                                                             such
                                                                                                                             invalidity,
                                                                                                                             illegality
                                                                                                                             or
                                                                                                                             unenforceability
                                                                                                                             shall
                                                                                                                             not
                                                                                                                             affect
                                                                                                                             the
                                                                                                                             validity,
                                                                                                                             legality
                                                                                                                             or
                                                                                                                             enforceability
                                                                                                                             of
                                                                                                                             any
                                                                                                                             other
                                                                                                                             provision
                                                                                                                             of
                                                                                                                             this
                                                                                                                             Agreement
                                                                                                                             in
                                                                                                                             such
                                                                                                                             jurisdiction
                                                                                                                             or
                                                                                                                             affect
                                                                                                                             the
                                                                                                                             validity,
                                                                                                                             legality
                                                                                                                             or
                                                                                                                             enforceability
                                                                                                                             of
                                                                                                                             any
                                                                                                                             provision
                                                                                                                             in
                                                                                                                             any
                                                                                                                             other
                                                                                                                             jurisdiction,
                                                                                                                             but
                                                                                                                             this
                                                                                                                             Agreement
                                                                                                                             shall
                                                                                                                             be
                                                                                                                             reformed,
                                                                                                                             construed
                                                                                                                             and
                                                                                                                             enforced
                                                                                                                             in
                                                                                                                             such
                                                                                                                             jurisdiction
                                                                                                                             as
                                                                                                                             if
                                                                                                                             such
                                                                                                                             invalid,
                                                                                                                             illegal
                                                                                                                             or
                                                                                                                             unenforceable
                                                                                                                             provision
                                                                                                                             had
                                                                                                                             never
                                                                                                                             been
                                                                                                                             contained
                                                                                                                             herein.

 

		13.16	Third
                                                                                                                                    Party
                                                                                                                                    Beneficiaries.
                                                                                                                                    Except
                                                                                                                                    as
                                                                                                                                    expressly
                                                                                                                                    provided
                                                                                                                                    with
                                                                                                                                    respect
                                                                                                                                    to
                                                                                                                                    BRNI
                                                                                                                                    Indemnitees
                                                                                                                                    and
                                                                                                                                    Neurotrope
                                                                                                                                    Indemnitees
                                                                                                                                    in
                                                                                                                                    Article
                                                                                                                                    10,
                                                                                                                                    there
                                                                                                                                    are
                                                                                                                                    no
                                                                                                                                    third
                                                                                                                                    party
                                                                                                                                    beneficiaries
                                                                                                                                    intended
                                                                                                                                    hereunder
                                                                                                                                    and
                                                                                                                                    no
                                                                                                                                    other
                                                                                                                                    party
                                                                                                                                    shall
                                                                                                                                    have
                                                                                                                                    any
                                                                                                                                    right
                                                                                                                                    or
                                                                                                                                    obligation
                                                                                                                                    hereunder.

 

		13.17	Waivers
                                                                                                                                    and
                                                                                                                                    Modifications.
                                                                                                                                    The
                                                                                                                                    failure
                                                                                                                                    of
                                                                                                                                    any
                                                                                                                                    Party
                                                                                                                                    to
                                                                                                                                    enforce
                                                                                                                                    any
                                                                                                                                    of
                                                                                                                                    the
                                                                                                                                    provisions
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    shall
                                                                                                                                    in
                                                                                                                                    no
                                                                                                                                    way
                                                                                                                                    be
                                                                                                                                    construed
                                                                                                                                    as
                                                                                                                                    a
                                                                                                                                    waiver
                                                                                                                                    of
                                                                                                                                    such
                                                                                                                                    provisions
                                                                                                                                    and
                                                                                                                                    shall
                                                                                                                                    not
                                                                                                                                    affect
                                                                                                                                    the
                                                                                                                                    right
                                                                                                                                    of
                                                                                                                                    such
                                                                                                                                    Party
                                                                                                                                    thereafter
                                                                                                                                    to
                                                                                                                                    enforce
                                                                                                                                    each
                                                                                                                                    and
                                                                                                                                    every
                                                                                                                                    provision
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    in
                                                                                                                                    accordance
                                                                                                                                    with
                                                                                                                                    its
                                                                                                                                    terms.
                                                                                                                                    No
                                                                                                                                    waiver
                                                                                                                                    of
                                                                                                                                    any
                                                                                                                                    of
                                                                                                                                    the
                                                                                                                                    provisions
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    shall
                                                                                                                                    be
                                                                                                                                    effective
                                                                                                                                    unless
                                                                                                                                    it
                                                                                                                                    is
                                                                                                                                    expressly
                                                                                                                                    stated
                                                                                                                                    to
                                                                                                                                    be
                                                                                                                                    a
                                                                                                                                    waiver
                                                                                                                                    and
                                                                                                                                    communicated
                                                                                                                                    to
                                                                                                                                    the
                                                                                                                                    other
                                                                                                                                    Party
                                                                                                                                    in
                                                                                                                                    writing
                                                                                                                                    by
                                                                                                                                    the
                                                                                                                                    waiving
                                                                                                                                    Party.
                                                                                                                                    No
                                                                                                                                    modification
                                                                                                                                    or
                                                                                                                                    amendment
                                                                                                                                    of
                                                                                                                                    any
                                                                                                                                    provision
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    shall
                                                                                                                                    be
                                                                                                                                    valid
                                                                                                                                    or
                                                                                                                                    effective
                                                                                                                                    unless
                                                                                                                                    in
                                                                                                                                    writing
                                                                                                                                    and
                                                                                                                                    signed
                                                                                                                                    by
                                                                                                                                    each
                                                                                                                                    of
                                                                                                                                    Parties
                                                                                                                                    hereto.

 

		13.18	Remedies
                                                                                                                                    Cumulative.
                                                                                                                                    Unless
                                                                                                                                    expressly
                                                                                                                                    stated
                                                                                                                                    otherwise
                                                                                                                                    in
                                                                                                                                    this
                                                                                                                                    Agreement,
                                                                                                                                    all
                                                                                                                                    remedies
                                                                                                                                    provided
                                                                                                                                    in
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    will
                                                                                                                                    be
                                                                                                                                    cumulative
                                                                                                                                    and
                                                                                                                                    in
                                                                                                                                    addition
                                                                                                                                    to,
                                                                                                                                    and
                                                                                                                                    not
                                                                                                                                    in
                                                                                                                                    lieu
                                                                                                                                    of,
                                                                                                                                    any
                                                                                                                                    other
                                                                                                                                    remedies
                                                                                                                                    available
                                                                                                                                    to
                                                                                                                                    either
                                                                                                                                    Party
                                                                                                                                    at
                                                                                                                                    law,
                                                                                                                                    in
                                                                                                                                    equity,
                                                                                                                                    or
                                                                                                                                    otherwise.

 

		13.19	Business
                                                                                                                                    Days.
                                                                                                                                    If
                                                                                                                                    any
                                                                                                                                    time
                                                                                                                                    period
                                                                                                                                    for
                                                                                                                                    giving
                                                                                                                                    notice
                                                                                                                                    or
                                                                                                                                    taking
                                                                                                                                    action
                                                                                                                                    hereunder
                                                                                                                                    expires
                                                                                                                                    on
                                                                                                                                    a
                                                                                                                                    day
                                                                                                                                    which
                                                                                                                                    is
                                                                                                                                    a
                                                                                                                                    Saturday,
                                                                                                                                    Sunday
                                                                                                                                    or
                                                                                                                                    legal
                                                                                                                                    holiday
                                                                                                                                    in
                                                                                                                                    the
                                                                                                                                    State
                                                                                                                                    of
                                                                                                                                    West
                                                                                                                                    Virginia,
                                                                                                                                    the
                                                                                                                                    time
                                                                                                                                    period
                                                                                                                                    shall
                                                                                                                                    automatically
                                                                                                                                    be
                                                                                                                                    extended
                                                                                                                                    to
                                                                                                                                    the
                                                                                                                                    business
                                                                                                                                    day
                                                                                                                                    immediately
                                                                                                                                    following
                                                                                                                                    such
                                                                                                                                    Saturday,
                                                                                                                                    Sunday
                                                                                                                                    or
                                                                                                                                    legal
                                                                                                                                    holiday.

 

    	 

    	 

    

 

		13.20	Consent
                                                                                                                                    and
                                                                                                                                    Approval.
                                                                                                                                    Except
                                                                                                                                    as
                                                                                                                                    and
                                                                                                                                    to
                                                                                                                                    the
                                                                                                                                    extent
                                                                                                                                    otherwise
                                                                                                                                    expressly
                                                                                                                                    provided
                                                                                                                                    in
                                                                                                                                    such
                                                                                                                                    approval,
                                                                                                                                    permission
                                                                                                                                    or
                                                                                                                                    consent,
                                                                                                                                    an
                                                                                                                                    approval,
                                                                                                                                    permission
                                                                                                                                    or
                                                                                                                                    consent
                                                                                                                                    given
                                                                                                                                    by
                                                                                                                                    a
                                                                                                                                    Party
                                                                                                                                    under
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    shall
                                                                                                                                    not
                                                                                                                                    relieve
                                                                                                                                    the
                                                                                                                                    other
                                                                                                                                    Party
                                                                                                                                    from
                                                                                                                                    responsibility
                                                                                                                                    for
                                                                                                                                    complying
                                                                                                                                    with
                                                                                                                                    the
                                                                                                                                    requirements
                                                                                                                                    of
                                                                                                                                    this
                                                                                                                                    Agreement,
                                                                                                                                    nor
                                                                                                                                    shall
                                                                                                                                    it
                                                                                                                                    be
                                                                                                                                    construed
                                                                                                                                    as
                                                                                                                                    a
                                                                                                                                    waiver
                                                                                                                                    of
                                                                                                                                    any
                                                                                                                                    rights
                                                                                                                                    under
                                                                                                                                    this
                                                                                                                                    Agreement.
                                                                                                                                    Unless
                                                                                                                                    otherwise
                                                                                                                                    set
                                                                                                                                    forth
                                                                                                                                    herein,
                                                                                                                                    with
                                                                                                                                    respect
                                                                                                                                    to
                                                                                                                                    any
                                                                                                                                    consent,
                                                                                                                                    permission
                                                                                                                                    or
                                                                                                                                    approval
                                                                                                                                    of
                                                                                                                                    a
                                                                                                                                    Party
                                                                                                                                    required
                                                                                                                                    under
                                                                                                                                    this
                                                                                                                                    Agreement,
                                                                                                                                    such
                                                                                                                                    consent,
                                                                                                                                    permission
                                                                                                                                    or
                                                                                                                                    approval:
                                                                                                                                    (i)
                                                                                                                                    shall
                                                                                                                                    be
                                                                                                                                    subject
                                                                                                                                    to
                                                                                                                                    such
                                                                                                                                    Party’s
                                                                                                                                    sole
                                                                                                                                    discretion;
                                                                                                                                    and
                                                                                                                                    (ii)
                                                                                                                                    shall
                                                                                                                                    not
                                                                                                                                    be
                                                                                                                                    effective
                                                                                                                                    unless
                                                                                                                                    and
                                                                                                                                    until
                                                                                                                                    such
                                                                                                                                    consent,
                                                                                                                                    permission
                                                                                                                                    or
                                                                                                                                    approval
                                                                                                                                    is
                                                                                                                                    given
                                                                                                                                    in
                                                                                                                                    writing.

 

		13.21	Right
                                                                                                                                    to
                                                                                                                                    Restructure
                                                                                                                                    Agreement.
                                                                                                                                    In
                                                                                                                                    the
                                                                                                                                    event
                                                                                                                                    the
                                                                                                                                    Internal
                                                                                                                                    Revenue
                                                                                                                                    Service
                                                                                                                                    proposes
                                                                                                                                    to
                                                                                                                                    deny
                                                                                                                                    or
                                                                                                                                    negatively
                                                                                                                                    affect
                                                                                                                                    the
                                                                                                                                    tax
                                                                                                                                    exempt
                                                                                                                                    status
                                                                                                                                    and/or
                                                                                                                                    public
                                                                                                                                    charity
                                                                                                                                    status
                                                                                                                                    of
                                                                                                                                    BRNI,
                                                                                                                                    or
                                                                                                                                    otherwise
                                                                                                                                    proposes
                                                                                                                                    to
                                                                                                                                    take
                                                                                                                                    substantially
                                                                                                                                    adverse
                                                                                                                                    action
                                                                                                                                    against
                                                                                                                                    any
                                                                                                                                    of
                                                                                                                                    the
                                                                                                                                    Parties,
                                                                                                                                    the
                                                                                                                                    Parties
                                                                                                                                    shall
                                                                                                                                    use
                                                                                                                                    their
                                                                                                                                    respective
                                                                                                                                    best
                                                                                                                                    efforts
                                                                                                                                    to
                                                                                                                                    restructure
                                                                                                                                    this
                                                                                                                                    Agreement
                                                                                                                                    in
                                                                                                                                    such
                                                                                                                                    a
                                                                                                                                    way
                                                                                                                                    as
                                                                                                                                    to
                                                                                                                                    avoid
                                                                                                                                    such
                                                                                                                                    affect
                                                                                                                                    and/or
                                                                                                                                    action
                                                                                                                                    by
                                                                                                                                    the
                                                                                                                                    Internal
                                                                                                                                    Revenue
                                                                                                                                    Service.

 

*********

 

    	 

    	 

    

 

IN WITNESS WHEREOF,
each of the Parties hereto, by its duly authorized representative, has caused this Agreement to be executed as of the Execution
Date of this Agreement.

 

NEUROTROPE BIOSCIENCE, INC.

By:/s/ John H. Abeles M.D

(Signature)

Name:John H. Abeles M.D.

Title:Chairman

 

BLANCHETTE ROCKEFELLER NEUROSCIENCES
INSTITUTE

By:/s/ William Singe

(Signature)

 

Name:William Singer

Title:President

 

NRV II, LLC

By:/s/ William Singer

(Signature)

 

Name:William Singer, Director of Neuroscience
Research Ventures, Inc.

Title:Managing Member of NRV II, LLC

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