Document:

Manufacturing Supply Agreement dated July 1, 2004

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Exhibit 10.23 
  
 MANUFACTURING SUPPLY AGREEMENT 
  
 This Manufacturing Supply Agreement (the “Agreement”), effective as of July 1, 2004 (the “Effective Date”), is made by and between Organichem Corporation, a Delaware corporation with its
principal place of business at 33 Riverside Avenue, Rensselaer, New York 12144-2900 (“Organichem”), Organichem’s parent company, Albany Molecular Research, Inc., a Delaware corporation with its principal place of business at 21
Corporate Circle, Albany, New York 12203-5154 (“AMRI”), and Telik, Inc., a Delaware corporation with its principal place of business at 3165 Porter Drive, Palo Alto, California 94304-1213 (“Telik”). 
  
 BACKGROUND 
  
 Telik, Organichem, and AMRI have collaborated on the development and manufacture of
Telik’s product, TLK286, and Organichem and AMRI have developed for the benefit of Telik intellectual property relating thereto. Telik desires to engage Organichem to perform manufacturing services for Telik, and Organichem desires to accept
such engagement on the terms and conditions set forth in this Agreement, including the Exhibits which are attached hereto and incorporated herein by reference. AMRI is a party to this Agreement for the limited purpose of confirming Telik’s
ownership of certain intellectual property related to the Product and related purposes, as set forth in detail in Section 14 below, which are a material condition to this Agreement. For the avoidance of doubt, AMRI shall not be responsible for the
obligations of Organichem hereunder except as provided by law, such as, for example, in an alter ego action involving Organichem. 
  
 NOW, THEREFORE, Organichem, AMRI, and Telik hereby agree as follows: 
  
 Definitions: 
  
 “Adverse Event” means any unexpected or potentially dangerous reaction to the Product or Telik Product. 
  
 “AMRI Developments” means all developments, improvements, processes and the like that are related to the Product or its manufacture, whether or not
patentable and whether or not in writing, that have been conceived or first reduced to practice by AMRI during the course of its relationship with Telik prior to the Effective Date of this Agreement. 
  
 “cGMPs” means the then-current good manufacturing practices required by the
FDA for the manufacture and testing of pharmaceutical materials, and any applicable, comparable laws or regulations in jurisdictions outside the U.S. 
  
 “Changed Services” means Services which have been changed or clarified. 
  
 “Claims” means all third-party claims, damages, liabilities, losses, costs and expenses. 
  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 “Deliverables” means all products, services, information, reports, and data that Organichem is responsible for providing Telik under this Agreement, and
consists of Product-Related Deliverables and Other Deliverables. 
  
 “Facility” means Organichem’s manufacturing facility located at the address first stated above. 
  
 “FDA” means the U.S. Food and Drug Administration and its constituent agencies. 
  
 “General Developments” means all developments, improvements, processes and the like, whether or not patentable and whether
or not in writing, that are conceived or first reduced to practice by Organichem in the course of performing the Services under this Agreement, which [*] to the [*] of Organichem and do not fall within the definition of
“Organichem Developments” below. 
  
 “MNA” means the
Mutual Non-Disclosure Agreement dated March 20, 2002 among the parties hereto and various other parties. 
  
 “Organichem Developments” means all developments, improvements, processes and the like that are [*], whether or not patentable and whether or not in writing, that are conceived or first reduced
to practice by Organichem in the course of performing the Services under this Agreement, and all developments, improvements, processes and the like that are [*], whether or not patentable and whether or not in writing, that have been
conceived or first reduced to practice by Organichem during the course of its relationship with Telik prior to the Effective Date of this Agreement. 
  
 “Other Deliverables” means all Deliverables other than Product-Related Deliverables. 
  
 “Product” means any form of TLK286. 
  
 “Product-Related Deliverables” means Deliverables related to the manufacture of the Product. 
  
 “Quality Agreement” means a memorandum of understanding prepared by Telik
and Organichem regarding quality assurance. 
  
 “Recall” means
any voluntary or involuntary action to temporarily or permanently remove any Product or Telik Product from commerce. 
  
 “Required Change” means any specification or manufacturing process change that is required by the FDA or other regulatory body. 
  
 “Seizure” means the impounding or restriction of movement of any Product or
Telik Product by regulatory or government action. 
  
 “Services”
means all services of any character provided by Organichem under this Agreement, including Changed Services. 
  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 “Telik Materials” means the materials specified in Exhibit 1, which may be revised at any time in accordance with this Agreement. 
  
 “Telik Product” means any product incorporating the Product. 
  
 “Telik Technology” means all proprietary technology of Telik necessary to or
desirable in providing the Services, in which Telik possesses a right to sublicense the same to Organichem. 
  

	1.	Purchase and Sale of Services. 

  
 1.1    Services. During the term of this Agreement, Organichem shall provide to Telik, and Telik shall purchase from
Organichem, services relating to (a) the manufacture of the Product for clinical uses; (b) validation of the manufacturing process for the Product in accordance with a mutually approved validation protocol; (c) commercial manufacture of Product
according to the validated manufacturing process in quantities forecast by Telik in accordance with Section 1.3; and (d) associated services as mutually agreed to. All Product produced under this Agreement shall be manufactured in accordance with
cGMPs. The Services shall be performed at the Facility or at such other facility upon which the parties may agree in a signed writing. Organichem shall not subcontract any Services or utilize another facility without Telik’s prior written
consent, which shall not be unreasonably withheld. 
  
 1.2    Changed Services. Either Telik or Organichem may request Changed Services. If Telik is the requesting party, Telik will provide Organichem with a written request for the change, signed by an authorized
representative of Telik, with a detailed explanation of the requested change. Upon receipt of such a request, Organichem shall provide Telik with a written statement describing in detail any associated increases or decreases in costs and any changes
in the timelines provided in this Agreement. No Changed Services shall be performed by Organichem without the prior written consent of both parties’ authorized representatives. All Changed Services to which the parties consent shall be subject
to all of the provisions of this Agreement, other than any provisions that they expressly supersede. Each party shall bear any costs associated with its preparation or review of a request for Changed Services. 
  
 1.3    Forecasts and Ordering. By the last day of
each calendar quarter, Telik shall provide Organichem with a forecast containing: (a) a purchase order for Product to be manufactured during the [*] calendar quarters thereafter (the purchase order for the [*] quarters having been
issued with the previous forecast, on an ongoing basis), which shall constitute an affirmative obligation for Telik to purchase and for Organichem to manufacture (subject to Section 1.4 below) such Product; and (b) a forecast for the following
[*] quarters, which shall constitute Telik’s good faith estimate of expected purchases of Product, but shall not constitute an obligation to manufacture or purchase the Product. The purchase order shall be for a quantity not less than
[*] of the forecast for such quarter made one quarter before. For the avoidance of doubt and by way of 

  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 example, on or prior to any September 30 during the term of this Agreement, Telik will address the then upcoming year as follows: 
  
 [*] 
  
 1.4    Capacity and Production. Organichem shall use its best efforts to make available
sufficient capacity for performance of the Services and to manufacture Product in accordance with purchase orders issued in accordance with Section 1.3. If any purchase order is for greater than [*] of the forecast for such quarter made one
quarter before, Organichem shall only be obliged to manufacture [*] of such forecast, but shall use reasonable efforts to supply amounts in excess of that quantity. If Organichem expects it will be unable to deliver Product to meet the
purchase orders or the forecast for any reason, including without limitation plant capacity constraints, it shall promptly notify Telik and the parties shall discuss appropriate steps to alleviate such expected inability to deliver. Telik shall have
the right to alleviate any reasonably expected inability to deliver by purchases from third parties notwithstanding the minimum purchase obligations of Telik under Article 5, in the manner provided in Section 21. If in any quarter Organichem has a
production shortfall of at least [*], except to the extent such shortfall is excused pursuant to Section 21, and then in the next quarter either has any production shortfall or fails to make up the production shortfall for the previous
quarter, Organichem shall reduce the price per kilogram for Product for deliveries in the following [*] quarters by [*]. 
  

	2.	Materials. 

  
 2.1    Telik Materials. Telik will provide to Organichem, at Telik’s expense, the Telik Materials, which are required for
Organichem to perform the Services. The Telik Materials shall be provided in a manner and according to [*]. Telik will deliver all Telik Materials to the Facility and will be responsible for all freight, insurance and other costs of
transport. Organichem shall receive, store, test, and release the Telik Materials against mutually approved specifications and in accordance with cGMPs. The Telik Materials and their specifications may be revised at any time by mutual agreement. The
parties acknowledge that at the time of entering this Agreement the long-term stability of the Telik Materials has not been established and Organichem shall not be held responsible for decomposition of the Telik Materials unless the decomposition
was caused by Organichem’s failure to comply with the terms of this Agreement. 
  
 2.2    Ownership, Use and Replacement of Telik Materials. Telik shall retain sole ownership of all Telik Materials. Organichem may use the Telik Materials only for purposes of performing its
obligations under this Agreement. Following termination of this Agreement, Organichem, if requested by Telik, and at Telik’s expense, shall promptly return to Telik any remaining Telik Materials. If any Telik Materials suffer loss or damage,
including loss in manufacture of Product, due to Organichem’s negligence or wrongful acts or omissions while in Organichem’s possession, custody or control (including, without limitation, any failure by Organichem to adhere to agreed
processes 

  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 or the terms of this Agreement), [*] for such Telik Materials. With respect to loss or damage to Telik Materials occurring other than as a result
of Organichem’s negligence or wrongful acts or omissions: (a) if the loss occurs in the course of [*] shall be responsible for replacing the affected Telik Materials, or (b) if the loss occurs in the course of [*], or if the loss
occurs at [*] during this Agreement [*], then [*] for the affected Telik Materials. For the purpose of this section, the period during which [*] shall be considered to end on the date on which the [*] either has
successfully [*] as compared to [*] or is no longer being [*]. 
  
 2.3    Other Materials. Organichem shall purchase all raw materials other than Telik Materials that are necessary for performance of the Services. All such raw materials shall be purchased
at Organichem’s expense. Organichem shall receive, test, and release all such raw materials against mutually approved specifications. 
  

	3.	Technology Transfer. Telik hereby grants to Organichem a non-exclusive, non-transferable, royalty-free license to all Telik Technology for the sole purpose of performing the
Services on behalf of Telik. Telik will transfer the Telik Technology, without charge, to Organichem by providing written materials and assistance of Telik personnel as may be reasonably requested by Organichem. All information and technology
licensed, sublicensed or provided to Organichem hereunder shall be subject to the confidentiality provisions of Article 13. 

  

	4.	Deliverables, Specifications, Acceptance, Rejection, Rework. 

  
 4.1    Product-Related Deliverables. Product-Related Deliverables to be provided to Telik hereunder are identified in Exhibit
2. Organichem shall provide a copy of the Master Batch Records for the Product to Telik promptly after each approved revision, and shall provide the remaining Product-Related Deliverables other than the Product to Telik at the time specified in
Exhibit 2. 
  
 4.2    Other
Deliverables. Other Deliverables shall be provided to Telik in accordance with mutually agreed procedures. 
  
 4.3    Specifications, Revision, Rework. The Product shall conform to the specifications set forth in Exhibit 3 (as they may be
revised in accordance with this Section 4.3) and the warranties of Section 18.1. Telik and Organichem may revise these specifications and/or the manufacturing process on mutual written consent (not to be unreasonably withheld) except that neither
party may withhold its consent to any Required Change. Organichem shall advise Telik if the implementation of any change to the specifications or manufacturing process will result in material additional costs or cost reductions for Product
manufacture and any increase in Product price that Organichem seeks if such change is implemented. Neither party shall be obliged to implement a change resulting in material additional costs, other than a Required Change, unless Telik and Organichem
agree on any Product price increase associated with it. For any Required Change, Telik and Organichem shall [*] any [*], or any [*] sought by [*]. 

  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Organichem shall conduct any rework or reprocessing of Product or components thereof only in accordance with procedures that are referenced in the
specifications and master batch records and permitted under any New Drug Application for the Product. 
  
 4.4    Acceptance. For each lot of Product, Telik shall, within [*] days of its receipt of the Product-Related
Deliverables other than Product, complete its review of the same. If the Product-Related Deliverables are reasonably acceptable to Telik, Telik shall accept the Product. Telik shall provide written reasons for non-acceptance of any Product, and
Telik and Organichem shall then cooperate to determine whether non-acceptance is justified. Once Telik provides notice of acceptance of the Product to Organichem, Organichem shall provide Product to the shipper designated by Telik, at the Facility.
Title to and the risk of loss and damage of the Product shall pass to Telik upon acceptance by such shipper. [*] shall be responsible for arranging and paying for all freight, insurance and other costs, expenses, fees, duties and charges of
whatever kind arising from and after such time [*]. 
  
 4.5    Rejection. Notwithstanding Telik’s acceptance of Product under Section 4.4, Telik may subsequently reject Product for breach of Organichem’s warranties under Section 18.1 by giving written notice
to Organichem specifying the basis for the rejection, upon which the parties will cooperate to determine whether such rejection is justified. Organichem will notify Telik promptly whether it accepts Telik’s basis for such rejection. If Telik
and Organichem disagree whether the Product complies with the warranties, they will submit an agreed sample of the Product to an independent qualified laboratory, mutually agreed upon by Telik and Organichem, for analysis and a determination whether
it complies with the warranties. Both parties shall be bound by the results of such independent review, the cost of which shall be borne by the party against whom the independent reviewer rules; and Telik shall purchase any lot of Product that
independent review determines to comply with the warranties, whether or not Organichem has already made a replacement lot. 
  
 4.6    Manufacture of Replacement Product. If Product is not accepted or is rejected by Telik and the non-acceptance or
rejection is agreed to by Organichem or upheld by any independent review requested by Organichem under Section 4.5, Organichem shall refund any monies paid by Telik for such Product, and credit Telik with Telik’s cost of Telik Materials used in
such Product. Following any such non-acceptance or rejection, Telik may (but shall not be obliged to) request that Organichem propose a plan to either remanufacture or rework (at Organichem’s option) the affected Product. Organichem shall
promptly propose such a plan, which will include a time table for production and sufficient detail to enable Telik to evaluate the feasibility of the plan. Upon Telik’s acceptance of the plan to remanufacture or rework, as the case may be,
Organichem shall use its best efforts to rework the Product or manufacture replacement Product as soon as possible in accordance with Section 4.3 above. Unaccepted and rejected Product: (a) shall be returned to Organichem at its expense and in the
form such Product exists at the time; and (b) shall not count toward the satisfaction of any production requirements of 

  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Organichem herein, including those set forth in Section 1.4, or serve as the basis for any failure by Telik to meet any of its purchase requirements
herein. 
  
 4.7    Quality Agreement.
Telik and Organichem shall jointly prepare the Quality Agreement. 
  

	5.	Minimum Purchase Requirements and Price. 

  
 5.1    Minimum Purchases. During [*] and [*], Telik shall purchase from Organichem at least [*] of its
requirements for Product to be consumed in the United States. Beginning in [*], and continuing until a [*] following the date on which the FDA approves the commercial sale of the Product in the United States for any purpose, Telik
shall purchase from Organichem at least [*] of its requirements for Product to be consumed in the United States. These minimum purchase percentages: (a) will be measured on the basis of [*], or for the final period, on the basis of the
partial [*] commencing [*] in which the above, [*] period ends, and (b) will [*] the consideration of Product manufactured by any alternate manufacturer for the purpose of [*], even if such Product is ultimately
used for [*]. 
  
 5.2    Payment for
Product and Alternate Manufacturing. Telik shall pay Organichem for Product in accordance with purchase orders under Section 1.3, and for other Services as mutually agreed. The price for Product for the period ending [*] shall be as in
Exhibit 4, as reduced in accordance with part F of Exhibit 4 if Organichem does not perform one or both of the early reaction steps described in that part F. Telik and Organichem shall meet no later than [*] to renegotiate in good faith the
price applicable for the [*] months starting on [*], and the parties will strive to reach a complete agreement on price no later than [*]. The parties will follow this process annually thereafter, meeting no later than
[*], and setting a price by [*], of each successive year. During any such renegotiation, and at any time prior to the date on which Telik and Organichem reach an agreement on the new price as evidenced in a writing signed by those
parties, Telik may introduce a bona fide price for the Product offered in writing by an alternate manufacturer (including any purchaser or transferee referred to in Section 23.2). For the avoidance of misunderstanding, a bona fide price for the
Product shall mean the alternate manufacturer shall: (a) have produced for Telik a batch compliant with cGMPs to be used as a basis for FDA registration, and (b) be ready and able to enter into an agreement with Telik having substantially similar
terms and conditions to those in this Agreement and accompanying Exhibits. If the bona fide price is not based on the same manufacturing process then employed by Organichem to produce the Product, then Organichem may offer to Telik a counterproposal
based on an alternative process, which Telik will consider in good faith. If Organichem is unable to match or beat that offered price, or if the counterproposal is not acceptable to Telik, then the minimum purchase obligation percentage identified
above shall continue in effect through [*] of the following year, shall reduce to [*] from [*] to [*] of that year, and shall not apply (i.e. reduce to [*]) thereafter. 
  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 5.3    Payment for Services. Organichem may issue an invoice for Services at any time after all Deliverables for such Services
have been provided to Telik. Payment for Services shall be due within [*] of the date of Telik’s receipt of the applicable Organichem invoice. 
  

	6.	Taxes. Organichem shall be responsible for all national, state and/or local sales, use, value-added or other taxes or fees that Organichem may be required to pay or to
collect for the manufacture and/or profit it realizes under this Agreement. 

  

	7.	Record- and Sample-Keeping, and Telik Audit and Visits. Organichem shall maintain and retain all standard operating procedures, quality assurance manufacturing records,
validation records, batch production records and other records related to the performance of the Services, and samples of starting materials, reagents, intermediates, and Product, as required by the laws, rules, regulations and guidelines of the FDA
and other applicable regulatory authorities, and until such time as Telik approves the destruction or transfer to Telik of such records in a signed writing designating the material to be destroyed or transferred, which approval shall not be
unreasonably withheld. Telik personnel, and Telik designees reasonably acceptable to Organichem, shall have the right to review and copy such records at the Facility during regular business hours upon reasonable notice. Telik personnel, or Telik
designees reasonably acceptable to Organichem, shall have the right to be present at the Facility during preparation for and manufacture of Product, subject to the reasonable control of Organichem. 

  

	8.	Compliance with Law. Organichem shall comply with and shall obtain and maintain at its expense all approvals, licenses and permits required by all applicable U.S. laws,
regulations and guidelines in the provision of Services and Product hereunder, including, without limitation, cGMPs and those laws, regulations and guidelines relating to employee safety and health and environmental protection and stewardship.

  

	9.	Safety And Waste-Handling Procedures. Organichem shall be responsible for maintaining safety procedures for the handling and/or manufacture of Telik Materials, other raw
materials, intermediates, and the Product and for the generation, treatment, storage, and disposal of wastes relating thereto, all of which shall comply with all U.S. federal, state, and local environmental and occupational safety and health
requirements. Telik shall have the right to audit and comment on such procedures upon reasonable prior written notice to Organichem. 

  

	10.	 Regulatory Matters. Organichem shall be responsible for the documentation, validation, quality and regulatory matters and associated costs related to the
performance of the Services. Telik shall be responsible for the documentation, regulatory matters, and costs relating to the filing of applications for regulatory and marketing approval for the Product, and shall own such applications and approvals.
At [*] expense, Organichem shall assist Telik in the preparation of such applications, and shall participate in any meetings, provide required documentation, submit other filings, and perform other activities as required to become approved by
appropriate regulatory authorities as a 

  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  

	 	 manufacturer of the Product. Organichem shall, at [*] expense, participate with Telik in joint preparatory
activities for regulatory inspections. Organichem shall notify Telik of any regulatory inspections that may bear on the Product, where practicable sufficiently in advance of such inspection to permit Telik to attend. This Section 10 shall apply to
the performance of the Services, and to the regulatory and marketing approval for the Product, in the U.S. and, only upon the further written agreement of the parties, on a country-by-country basis outside the U.S. 

  

	11.	Warranties and Disclaimers. EXCEPT FOR THE WARRANTIES PROVIDED IN SECTION 18, NO PARTY MAKES ANY WARRANTY, EXPRESS OR IMPLIED, BY STATUTE OR IN WRITING, REGARDING THE
SERVICES, THE TELIK MATERIALS OR THE PRODUCT, INCLUDING WITHOUT LIMITATION ANY WARRANTY REGARDING THEIR FITNESS FOR ANY PURPOSE, THEIR QUALITY, THEIR MERCHANTABILITY, OR THEIR NON-INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES. ANY
OTHER REPRESENTATIONS OR WARRANTIES MADE BY ANY PERSON OR ENTITY, INCLUDING EMPLOYEES OR REPRESENTATIVES OF A PARTY HERETO, THAT ARE INCONSISTENT HEREWITH, SHALL BE DISREGARDED AND SHALL NOT BE BINDING ON SUCH PARTY. Nothing in this Section 11 is
intended as a limit on the obligations of indemnification under Section 16 or recall under Section 17. 

  

	12.	Limitations on Liability. IN NO EVENT SHALL ANY PARTY BE LIABLE TO ANOTHER PARTY OR ITS AFFILIATES FOR LOST PROFITS OR ANY SPECIAL, CONSEQUENTIAL, INCIDENTAL, PUNITIVE OR
INDIRECT DAMAGES ARISING FROM ANY BREACH OF THIS AGREEMENT, INCLUDING WITHOUT LIMITATION ANY BREACH OF A WARRANTY CONTAINED HEREIN OR OF ANY OBLIGATION TO PERFORM SERVICES AND/OR TO PROVIDE DELIVERABLES BY A SPECIFIED TIME. Liability of the parties
hereunder to each other (except for the obligations of indemnification under Section 16, for recall, seizure, or adverse events under Section 17, and for any acts constituting willful misconduct) shall be limited to [*] or [*],
whichever is less. 

  

	13.	Confidentiality and Non-use of Information. The conditions of confidentiality and non-use of information shall be governed by the MNA. Notwithstanding anything to the
contrary in the MNA, and notwithstanding the enforceability or unenforceability of the MNA as to any party to the MNA that is not a party to this Agreement, the MNA shall continue in full force and effect as to the parties to this Agreement until
the later of March 20, 2007 or [*] years following any expiration or termination of this Agreement. Without limiting the MNA: (a) the content and existence of this Agreement will be treated as Confidential Information and (b) where a party is
required by securities laws to disclose the existence of this Agreement or any content, such party will use reasonable efforts to seek confidential treatment and otherwise limit the disclosure to the maximum extent possible, and the other parties
will cooperate fully in this effort. 

  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  

	14.	Intellectual Property. 

  
 14.1    Infringement of Third Party Rights. In the event that any party becomes aware of any technology used in the manufacture
of Product that may infringe the rights of one or more third parties, such party shall promptly notify the others. The parties shall reasonably cooperate in evaluating and resolving any such situation. 
  
 14.2    Ownership of Organichem Developments.
Organichem Developments shall be solely owned by Telik, and Organichem by this Agreement assigns all of its rights, title and interest therein to Telik. Organichem shall promptly disclose all Organichem Developments to Telik, in writing, and shall
provide such further information with regard thereto as Telik may reasonably request. Organichem shall not publish or otherwise make public any Organichem Developments without Telik’s prior written consent. At Telik’s expense, Organichem
shall execute all documents and do all things that may be reasonably required in order to transfer to Telik, and to protect, Telik’s rights in Organichem Developments. Organichem shall ensure that appropriate, enforceable contracts, including
without limitation assignments of inventions and nondisclosure agreements, with employees and permitted subcontractors and other third parties, are in place to protect Telik against the loss of its intellectual property and the disclosure of its
confidential information and trade secrets. 
  
 14.3    Ownership of AMRI Developments. AMRI Developments shall be solely owned by Telik, and AMRI by this Agreement assigns all of its rights, title and interest therein to Telik. AMRI shall promptly disclose all
AMRI Developments to Telik, in writing, and shall provide such further information with regard thereto as Telik may reasonably request. AMRI shall not publish or otherwise make public any AMRI Developments without Telik’s prior written consent.
At Telik’s expense, AMRI shall execute all documents and do all things that may be reasonably required in order to transfer to Telik, and to protect, Telik’s rights in AMRI Developments. 
  
 14.4    Ownership of General Developments. General
Developments shall be solely owned by Organichem, subject to the license in Section 14.5 below. Organichem shall promptly disclose all General Developments to Telik, in writing, and shall provide such further information with regard thereto as Telik
may reasonably request. Telik shall not publish or otherwise make public any General Developments without Organichem’s prior written consent. 
  
 14.5    Use of Organichem/AMRI Intellectual Property. Organichem shall not use any intellectual property owned or controlled by
Organichem or AMRI in the performance of Services under this Agreement without first informing Telik in writing and receiving Telik’s written approval. Organichem and AMRI, by this Agreement, grant Telik an irrevocable, non-exclusive,
fully-paid worldwide license, with the right to sublicense, under all such Organichem and AMRI intellectual property (including without limitation General Developments) solely to make, have made, use, import, sell, and offer for sale Product and any
products incorporating the Product. 
  

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 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  

	15.	Insurance. Organichem represents and warrants that it presently maintains and shall continue to maintain during the term of this Agreement, at its own cost and expense,
insurance against the risks associated with its performance of the Services that is commercially reasonable as to terms, coverage, and coverage limits in view of the scope of its activities and obligations under this Agreement, with the minimum
coverages as follows: (i) worker’s compensation insurance in compliance with the worker’s compensation laws of the State of New York, and employer’s liability insurance with respect to employees, with a minimum limit of [*] per
occurrence; (ii) vehicle insurance for vehicles owned, leased, or operated by Organichem or its employees or agents in performing the Services, with a minimum combined single limit of [*] per occurrence; (iii) all risks property insurance
covering the Telik Materials and the Product while in the care, custody, and control of Organichem, with coverage of at least full replacement cost; and (iv) product liability insurance, with a minimum limit of [*]. Terms of such coverage
shall be evidenced by certificates of insurance to be furnished by Organichem to Telik at the inception of this Agreement and as may be reasonably requested thereafter. 

  

	16.	Indemnification. 

  
 16.1    By Telik. Telik shall indemnify and hold Organichem and AMRI and their respective directors, officers, employees and
agents harmless from and against any and all Claims relating to the Product after it has been provided to Telik’s designated shipper, to the extent arising from [*]; all except to the extent that such a Claim (a) is caused by the
negligence or willful misconduct of Organichem or its employees, agents, or representatives; or (b) is a Claim for which Organichem has an obligation to indemnify Telik under Section 16.2. 
  
 16.2    By Organichem. Organichem shall indemnify
and hold Telik and its respective directors, officers, employees and agents harmless from and against any and all Claims arising from [*], except to the extent that such a Claim [*]. 
  
 16.3    Indemnification Procedures. Any party
seeking indemnity hereunder (a) shall give prompt written notice to the other party (the “Indemnifying Party”) of any Claim for which indemnification is sought; (b) shall permit the Indemnifying Party to assume full responsibility to
investigate, prepare for, and defend against the Claim; (c) shall reasonably assist the Indemnifying Party, at the Indemnifying Party’s reasonable expense, in the investigation of, preparation for, and defense of such Claim; and (d) shall not
compromise or settle such Claim without the Indemnifying Party’s prior written consent. 
  

	17.	 Recalls, Seizures, and Adverse Events. If there is a recall or seizure or there are adverse events for any Product or Telik Product that may be related to
the Services, Organichem shall provide at Telik’s expense any assistance reasonably required by Telik in connection with such recall, seizure, or adverse events. If any Product or Telik Product is recalled or seized due to a breach of the
warranty in Section 18.1, Organichem shall reimburse Telik for such expenses and shall be responsible for out-of-pocket expenses 

  

 11 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  

	 	 incurred in connection with such recall or seizure including notification, transportation, destruction expenses, and
replacement costs of Product and/or Telik Product. 

  

	18.	Representations and Warranties. 

  
 18.1    Organichem warrants that each lot of Product delivered to Telik will, at the time of delivery to Telik’s designated
shipper: (i) be manufactured and stored in accordance with cGMPs and other applicable FDA and other rules and regulations of the United States; (ii) be manufactured in accordance with the agreed-upon manufacturing procedures described in the master
batch records; and (iii) conform to the specifications in effect when the Product was released. Organichem represents and warrants to Telik that it has not and will not use in connection with the Services in any capacity any persons debarred under
21 U.S.C. 335 or convicted of a felony under the laws of the United States for conduct relating to the regulation of any drug product under the Federal Food, Drug, and Cosmetic Act, as amended. 
  
 18.2    Each party represents and warrants to the other
parties that (a) such party has full power and authority to execute and deliver this Agreement and to perform its obligations hereunder; (b) the execution, delivery, and performance by such party of this Agreement has been duly and validly
authorized, and no additional authorization or consent is required in connection with the execution, delivery, and performance by such party of this Agreement; and (c) this Agreement has been duly executed and delivered by such party and constitutes
a valid and legally binding obligation of such party, enforceable in accordance with its terms. 
  

	19.	Term. Unless sooner terminated pursuant to Section 20, the term of this Agreement shall be from the Effective Date and continue until the later of: (a) [*] years
following the date on which the FDA approves the commercial sale of the Product in the United States for any purpose and (b) [*] following the date on which either Telik or Organichem gives notice of termination to the other parties.

  

	20.	Termination. This Agreement is subject to early termination as follows: 

  

20.1    By mutual written agreement of the parties, such termination to be effective as of the time specified in such written
agreement; or 
  
 20.2    By any party, upon
any material breach of this Agreement by another party; provided, however, that (a) the party alleging such breach must first give the other party written notice thereof, which notice must state the nature of the breach in reasonable detail, and
that the party giving such notice views such alleged breach as a basis for terminating this Agreement under this Section 20.2; (b) the party receiving such notice must have failed to cure the alleged breach within sixty (60) days after receipt of
such notice; and (c) the party alleging the breach shall have the option, prior to the expiration of the foregoing sixty (60) day period, to rescind its notice of termination and permit the Agreement to continue in effect, and any such rescission
shall not have the effect of 

  

 12 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 waiving or limiting the availability of any other remedy to which the party alleging the breach may be entitled; or 
  
 20.3    By any party upon the occurrence of (a)
[*] or more material breaches of this Agreement within a [*] month period; or (b) a breach of such a nature that it cannot be cured in a meaningful way; such termination to be effective immediately upon written notice by the party
alleging such repeated or incurable breaches (for the avoidance of doubt, written notice at the time of the prior breaches or events giving rise to this right to terminate is not required); or 
  
 20.4    By Telik, only in the event that TLK286 is not
approved for commercial sale by the FDA or that such approval is revoked during the term of this Agreement. Such termination shall be effective upon written notice to Organichem and AMRI. In event of such a termination, Organichem will be paid for
all Services rendered until the date of the notice of termination, and Organichem shall provide Telik with documentation of those expenses for which it seeks reimbursement that are attributable to the purchase of raw materials prior to termination,
reshelving, disposal, professional services (e.g. pilot studies), and documentation hereunder. Telik will reimburse Organichem for such documented expenses. No other payments shall be due. 
  
 20.5    By Telik, in accordance with Article 21, or in
the event Organichem has [*] production shortfalls of the character described in Section 1.4, followed in the [*] by a [*] production shortfall or failure to make up the production shortfalls from the [*] quarters. Any
such termination shall be effective immediately upon written notice to Organichem and AMRI. For the avoidance of doubt, written notice at the time of the prior production shortfalls giving rise to this right to terminate is not required. 

 
 20.6    In the event of termination under this Article
20, any remaining Telik Materials shall be delivered to Telik at Telik’s expense, and the disposition of intermediates and any unpurchased Product that meets specifications shall be provided to Telik at the price then in effect. Any other
Product shall be provided to Telik at a price that shall be negotiated in good faith by the parties. 
  
 20.7    Expiration or termination of this Agreement for any reason shall not release any party from any liability, obligation, or
agreement that has already accrued. The provisions of Articles 6, 7, 9, 10, 11, 12, 13, 14, 16, 20, and 23, and Sections 2.2 and 4.2 shall survive any expiration or termination of this Agreement. 
  

	21.	 Causes Beyond Control. Nonperformance by any party shall be excused to the extent and for the period of time that performance is rendered impossible by
strike, fire, flood, earthquake, windstorm, unanticipated or unavoidable governmental acts or restrictions (including without limitation acts or restrictions of the FDA), or any similar cause, provided the failure to perform is beyond the reasonable
control and not caused by the negligence or willful misconduct of the party seeking excuse from performance. In addition, nonperformance by Organichem shall be excused to the extent and for the 

  

 13 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  

	 	 period of time that performance is rendered impossible by any failure by Telik to meet its obligations under this
Agreement, including without limitation Telik’s failure to supply needed raw materials or reasonably to take delivery of the Product, provided the failure to perform is beyond the reasonable control of Organichem and not caused by the
negligence or willful misconduct of Organichem. Notwithstanding the foregoing, if any such event affects the performance of Organichem and extends beyond [*] months, Telik may forthwith terminate this Agreement. The parties recognize that
events of the character described in this section may necessitate that Telik seek, activate, or scale up an alternate source of supply of the Product, and that in so doing Telik will make contractual commitments to the alternate supplier. Therefore
to the extent any excused nonperformance involves Organichem’s failure to supply Product, all minimum purchase obligations of Telik herein shall be suspended and abated throughout the period of nonperformance, and where Telik has made any of
the foregoing contractual commitments, the minimum purchase obligations shall continue to be suspended and abated for the period and to the extent Telik considers reasonably necessary to enable it to comply with its contractual commitments to the
alternate supplier. In reaching any such agreement with an alternate supplier, Telik will endeavor to make contractual commitments to the supplier that minimize the duration of any such suspension or abatement of the minimum purchase obligations
herein. Organichem will notify Telik in writing as soon as possible of any event that is likely to affect Organichem’s performance hereunder, and will specify in the notice Organichem’s estimate of the duration of non-performance. Telik
may, upon receipt of any such notice, take immediate action to seek, activate, or scale up an alternate source of supply as described above. 

  

	22.	Notices. Any notice or other communication hereunder shall be in writing and shall be deemed given when so delivered in person by overnight courier (with receipt confirmed),
or by mail, upon receipt, addressed as follows or to such other persons and/or addresses as may be specified in a notice so given: 

  
 If to Telik: 
  
 Telik, Inc. 
 3165 Porter Drive 
 Palo Alto, CA 94304-1213 
 Attn: Chief
Financial Officer 
 Copy to: Vice President, Manufacturing 
 Fax No. (650) 845-7800 
  
 If
to Organichem: 
  
 Organichem Corporation 
 33 Riverside Avenue 
 Rensselaer, NY
12144-2900 
 Attn: President 
 Fax No. (518) 433-7719 
  

 14 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 If to AMRI: 
  
 Albany Molecular Research, Inc. 
 21 Corporate
Circle 
 Albany, NY 12203-5154 
 Attn: Chief Financial Officer 
 Fax No. (518) 464-0289 
  

	23.	Miscellaneous. 

  
 23.1    Independent Contractors. The relationship of Telik, Organichem, and AMRI hereunder is that of independent contractors.
No party, nor its employees, consultants or representatives, shall be considered employees, partners, or agents of any other party, and no party may make any representations or commitments on any other party’s behalf. Nothing in this Agreement
shall give rise to the creation of any labor relation by or between any party and any employees of any other party. 
  
 23.2    Assignment. (a) No party may transfer or assign its rights or obligations under this Agreement, directly or indirectly,
without the prior written consent of the other parties, other than to a person or other entity that acquires from such party all or substantially all of its business or assets, including by way of a merger or consolidation. A party shall notify the
others promptly following any such transfer, assignment, merger or consolidation. Any purported assignment in contravention of this Section 23.2 shall, at the option of any of the nonassigning parties, be null and void and of no effect. (b) This
Agreement shall be binding upon and shall inure to the benefit of the parties hereto and their successors and permitted assigns. In the event of a sale or transfer of substantially all of the business or assets of Telik, or in the event of a sale or
transfer of Telik’s rights in the Product in the United States, the purchaser or transferee in any such transaction shall be bound to the terms of the Agreement. 
  
 23.3    Waiver. No waiver of any term or condition of this Agreement shall be valid or binding on
either party unless agreed in writing by the party to be charged. The failure of either party at any time to enforce any of the provisions of the Agreement shall in no way be construed as a present of future waiver of such provisions or in any way
affect the rights of such party to enforce each and every such provision thereafter. Where remedial rights are specified in this Agreement (such as, without limitation and by way of example, the price discount in Section 1.4 and the reimbursement in
Section 17), the exercise of such rights by a party does not waive or limit the availability of other remedies to such party. 
  
 23.4    Severability. If any provisions of this Agreement are held to be void or unenforceable with regard to any particular
country, then such void or unenforceable provisions shall be replaced in such country by valid and enforceable provisions which will achieve as far as possible the economic business intentions of the parties. The 

  

 15 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 provisions not held to be void or unenforceable shall, however, remain in full force and effect, to the extent consistent with such economic business
intentions. 
  
 23.5    No Implied
Rights. Except as expressly provided herein, neither party shall have any right, title or interest to or in any patents, patent applications, know-how (whether patentable or unpatentable) or other intellectual property rights of the other party.

  
 23.6    Dispute Resolution. In the
event of any dispute arising under this Agreement that is not resolvable by the Vice President of Manufacturing of Telik and the President of Organichem, the dispute shall be submitted for resolution to the executives of the parties designated in
Section 22. Such executives shall endeavor diligently and in good faith to resolve the dispute within [*]. If the dispute has not been resolved by that time, any party may pursue its remedies through arbitration. 
  
 23.7    Arbitration. Any dispute, claim or
controversy arising out of or relating to this Agreement or the breach, termination, enforcement, interpretation or validity thereof, including the determination of the scope or applicability of this Agreement to arbitrate, shall be determined by
arbitration at [*] in [*] before a sole arbitrator, in accordance with the laws of the State of New York for agreements made in and to be performed in that State. The arbitration shall be administered by [*]. Judgment on the
arbitration award may be entered in any court having jurisdiction. 
  
 23.8    Injunction. Notwithstanding the provisions of the foregoing Sections 23.6 and 23.7, either party may seek injunctive or other equitable relief in any court having competent jurisdiction, and any issues
related to such relief may be adjudicated in the same forum. The parties submit to the jurisdiction and venue of the state and federal courts located in the [*]. 
  
 23.9    Counterparts. This Agreement may be executed in counterparts, each of which shall be
deemed an original and all of which together shall constitute one instrument. 
  
 23.10    Governing Law. This Agreement is made in accordance with and shall be governed by and construed under the laws of the [*] excluding its choice of laws principles. 

 
 23.11    Proposals and Order Documents. The
terms and conditions contained in this Agreement shall supersede any contrary terms and conditions contained in any proposal, acceptance, purchase order, or like document relating to the provision of Services by Organichem and their purchase by
Telik under this Agreement. 
  
 23.12    Entire Agreement. This Agreement, including the exhibits attached hereto, constitutes the entire agreement of the parties with respect to the subject matter hereof and supersedes all prior or
contemporaneous understandings or agreements between them with respect to the same, whether written or oral, except for the MNA referred to in Article 13 as modified herein, and the [*] obligations of Telik under the [*] between

  

 16 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Telik and AMRI. No amendment or modification of this Agreement shall be valid or binding upon the parties unless made in writing and signed by the duly
authorized representatives of both parties. 
  
 IN WITNESS WHEREOF, the parties
have entered into this Agreement as of the Effective Date. 
  
  

											
	ORGANICHEM CORPORATION	  	 	  	 	 	TELIK, INC.
						
	By:	 	 /s/    Thomas D’Ambra

	  	 	  	 	 	By:	  	 /s/    Cynthia M. Butitta

						
	Name:	 	 Thomas D’Ambra

	  	 	  	 	 	Name:	  	 Cynthia M. Butitta

						
	Title:	 	 CEO

	  	 	  	 	 	Title:	  	 COO & CFO

					
	ALBANY MOLECULAR RESEARCH, INC.	  	 	  	 	 	 	  	 
						
	By:	 	 /s/    Thomas D’Ambra

	  	 	  	 	 	 	  	 
						
	Name:	 	 Thomas D’Ambra

	  	 	  	 	 	 	  	 
						
	Title:	 	 Chairman, President & CEO

	  	 	  	 	 	 	  	 

  

 17 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Exhibit 1 
 Telik Materials

  
 [*] 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Exhibit 2 
 Organichem Deliverables

  

	1.	Copy of mutually approved [*] implemented in accordance with cGMPs; 

  

	2.	Copy of mutually approved analytical and microbiological (as applicable) test methods; 

  

	3.	Copy of [*] for each lot of an intermediate or the Product reviewed and approved by Organichem Quality Assurance (including a copy of any applicable discrepancy reports),
within [*] days after production of each intermediate or Product lot; 

  

	4.	Signed Certificate of cGMPs compliance for each lot of an intermediate or the Product, within [*] days after production of each lot; 

  

	5.	Copy of Signed Certificate of Analysis for each lot of an intermediate or the Product, within [*] days after production of each lot; 

  

	6.	Only upon the request of Telik, a copy of analytical/microbiological raw test data for each lot of intermediate or Product, within [*] days after production of each lot; and

  

	7.	Product packaged in accordance with mutually approved specifications, upon receipt of written authorization from Telik. 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Exhibit 3 
 Specifications for the
TLK286 Drug Substance 
  
 [*] 

 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF
THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 
  
 Exhibit 4 
 Pricing Schedule for
Product 
  
 Organichem shall invoice Telik in accordance with the pricing
schedule and the potential adjustments described in this Exhibit 4. Straight-line interpolation may be used where applicable. 
  
 “Current Scale” refers to the use of [*] starting material, and an expected baseline yield per batch of [*] of TLK286. 
  
 “Launch Scale” refers to the use of [*] starting material, and an expected
baseline yield per batch of [*] of TLK286. 
  
 “Straight-through
Processing” refers to the process in which intermediates are not accumulated, but processed directly in sequence to a single TLK286 lot. 
  
 “Campaign Processing” refers to the process in which intermediates are accumulated in multiple lots and processed to generate a series of TLK286 lots.

  

	A.	Current Scale; Straight-through Processing: 

  
 [*] 
  

	B.	Current Scale; Campaign Processing: 

  
 [*] 
  

	C.	Launch Scale, Straight-through Processing: 

  
 [*] 
  

	D.	Launch Scale; Campaign Processing: 

  
 [*] 
  

	E.	[*] 

  
 [*] 
  

	F.	Other Adjustments: 

 If some of the early steps in the
synthesis are not performed by Organichem, the prices in Sections A through D above will be reduced in accordance with the following schedule: 
  
 [*]Code of Ethics and Conduct

 Exhibit 10.1 
  
 HARBOR GLOBAL COMPANY LTD. 
 CALYPSO MANAGEMENT LLC 
  
 CODE OF
ETHICS & CONDUCT 
  
 Harbor Global Company Ltd. and Calypso
Management LLC (together, the “Company”, “we” or “us”) conducts their business affairs around the world with integrity, honesty and good sense. This Code sets forth some specific aspects of the Company’s commitment
to these values. This requires that we conduct our business in accordance with all applicable laws and regulations and in accordance with the highest standards of business ethics. We set forth in the succeeding pages the Company’s Code of
Ethics and Conduct (“Code”), that has been approved by our Board of Directors. 
  
 All officers, directors and employees (“you”) are expected to read the Code, know what it requires, and comply with it and with all applicable laws and regulations.. Please make sure that you understand the
code, the consequences of non-compliance, and the Code’s importance to the success of the Company. If you have any questions or concerns about illegal or unethical acts or any portion of the code, speak to your supervisor or to Donald H.
Hunter, the Company’s Compliance Officer for the Code in Boston (email: dhunter@harborglobal.com tel.:1-617-878-1601 mail: One Faneuil Hall Marketplace, Boson, MA 02109) or in Moscow to the Company’s internal auditor Elena Strelkova
(email:estrelkova@pioglobal.ru tel: 7-095-960-2903 mail:5 Gazetny Per. Moscow, Russia 125993). Failure to comply with this Code and the law may have severe financial and legal consequences. The Company will respond to failure to abide by this Code
and the law by appropriate disciplinary measures, up to and including dismissal. Retaliation for honestly reporting a concern regarding illegal or unethical conduct is prohibited. 
  
 Each of us is responsible for knowing and understanding the policies and guidelines contained in the following pages. If you
have questions, ask them; if you have ethical concerns, raise them. The Compliance Officer, who is responsible for overseeing and monitoring compliance with this Code, and the other resources referenced in this Code are available to answer your
questions and provide guidance. You should report any suspected misconduct to the Compliance Officer or the Board of Directors via the whistly-blower policy adopted by the Company. Our conduct should reflect the Company’s values, demonstrate
ethical leadership, and promote a work environment that upholds the Company’s reputation for integrity, ethical conduct and trust. To that end, both as a company and as individuals, we should: 
  

	•	Understand and make a personal commitment to this Code. 

  

	•	Lead by example, complying with the letter and spirit of the Code in always doing what is right, even when the alternatives seem easier or more expedient. 

 

	•	Understand and behave in accordance with the Code as well as all other Company policies, guidelines and procedures. 

  

	•	Ensure that we do not put our own interests ahead of the Company when performing our jobs, or use our positions in the Company, or information acquired through those positions, for
any non-Company purpose. 

  

	•	Conduct all work and business affairs lawfully and with integrity. 

  

	•	Provide the coaching and guidance necessary to ensure understanding of, and compliance with, the Code for those persons in our groups, departments or organizations.

	•	Seek assistance, guidance or interpretation on difficult ethical and legal issues from the Compliance Officer. 

  

	•	Report incidents of suspected unethical or unlawful conduct to the Compliance Officer or the Board of Directors via whistle-blower policy. 

  

	•	Take prompt, appropriate corrective action when an allegation of wrongdoing is substantiated. 

  

	•	Create a work environment that encourages frank, open and constructive communication on all business matters, including allowing everyone to ask questions, make suggestions and
report errors and wrongdoing without fear of reprisal. 

  

	1.	EMPLOYEES 

  

	 	1.1	Equal Opportunity 

  
 The Company will base employment decisions on employee qualifications and achievements, and will comply with local and national employment laws in
countries where the Company does business. The Company will not discriminate against any applicant or employee on grounds of race, religion, gender, national origin, sexual orientation, age, disability, or other legally prohibited factors.

  

	 	1.2	Harassment 

  
 Employees shall not engage in abusive, harassing or offensive conduct. Examples include demeaning comments based on ethnic characteristics, unwelcome
sexual advances, and threats of physical violence. 
  

	 	1.3	Safety and Health 

  
 Employees must follow applicable safety and health rules, and immediately report accidents, injuries, and unsafe equipment, practices or conditions.
Employees shall report to work free from the influence of any substance that could impair job performance. 
  

	2.	CUSTOMERS AND CONSUMERS 

  
 Company marketing and advertising should be accurate and truthful. You may not make or permit others to make deliberately misleading information,
omissions of important facts, or false claims. The Company will only obtain business legally and ethically. (See Conflicts of Interest, Section 8, below, regarding customer gifts, travel and entertainment.) 
  

	3.	DOING BUSINESS WITH OTHERS 

  

	 	3.1	Arrangements with Third Parties 

  
 The Company will not enter into business arrangements with other parties who intentionally violate the law, or who act unethically. The “law”
includes local environmental, employment, safety and anti-corruption statutes and regulations. You may not use a third party to perform any act prohibited by law or by this Code. 
  

	 	•	Agents and Consultants 

  
 Commissions or fees paid to agents, finders or consultants must be reasonable for the work done. You will not authorize or pay commissions or fees that
you have reason to believe will become bribes. 

	 	•	Subcontractors 

  
 Subcontractors must agree to act in accordance with this Code. 
  

	 	•	Joint Ventures and Alliances 

  
 The Company seeks to ally with companies that share our commitment to ethics. The Company will also work to make the standards of our joint ventures
compatible with our own. 
  

	 	3.2	Purchasing and Suppliers 

  
 Purchasing decisions must be made based on the Company’s best interests (see also Conflicts of Interest, Section 8, below). All purchasing is to be
conducted in accordance with relevant internal control policies. Payments must be on reasonable arms length terms. 
  

	4.	SHAREHOLDERS 

  

	 	4.1	Company Assets 

  
 We each have a duty to protect the Company’s assets and ensure their efficient use. Theft, carelessness and waste have a direct impact on the
Company’s profitability. We should take measures to prevent damage to and theft or misuse of Company property. When you leave the Company, all Company property, including without limitation work product developed in connection with Company
employment, in any storage format including electronic, must be returned to the Company. 
  
 You may use Company assets, such as funds, products, or computers, only for Company business. 
  

	 	4.2	Confidentiality 

  
 Each employee, officer and director must keep the Company’s proprietary information confidential and secure from all persons except those who need to
know it to do their jobs. Proprietary information is information not generally known to the public which is valuable to the Company or to others. Employees and directors who possess proprietary information must: 
  

	•	Not use the information for their own benefit or the benefit of persons inside or outside of the Company. 

  

	•	Carefully guard against disclosure of that information to people outside the Company. For example, you should not discuss such matters with family members or business or social
acquaintances or in places where the information may be overheard, such as taxis, public transportation, elevators or restaurants. 

  

	•	Not disclose confidential information to another employee unless the employee needs the information to carry out business responsibilities. 

  
 Confidentiality Agreements or Non-Disclosure Agreements are commonly used
when the Company needs to disclose confidential information to suppliers, consultants, potential business partners, or others. A Confidentiality Agreement puts the person receiving confidential information on notice that he or she must maintain the
secrecy of such information. If, in doing business with persons not employed by the Company, you foresee that you may need to disclose confidential information, you should call the Compliance Officer and discuss the utility of entering into a
Confidentiality Agreement. 
  
 Your obligation to treat
information as confidential does not end when you leave the Company. Upon the termination of your employment, you must return everything that belongs to the Company, 

 including all documents and other materials containing confidential information. You must not use the confidential
information you obtained at the Company or disclose confidential information to a new employer or to others after ceasing to be an employee. 
  

	 	4.3	Inside Information 

  
 You are prohibited by Company policy and the law from buying or selling securities of the Company at a time when in possession of “material nonpublic
information.” This conduct is known as “insider trading.” Passing such information on to someone who may buy or sell securities – known as “tipping” – is also illegal. The prohibition applies to Harbor Global
securities and to securities of other companies if you learn material nonpublic information about other companies, such as the Company’s business partners or clients, in the course of your duties for the Company. For additional information on
trading in the Company’s securities, consult the Insider Trading Policy 
  

	 	4.4	Company Books and Records 

  
 It is Company policy to make full, fair, accurate, timely and understandable disclosure in compliance with all applicable laws and regulations in all
reports and documents that the Company files with, or submits to, the Securities and Exchange Commission (“SEC”) and in all other public communications made by the Company. 
  
 You must complete all documents accurately, truthfully, and in a timely manner. When applicable, documents must be properly authorized. You
must record the Company’s financial activities in compliance with all applicable laws and accounting practices. Making false or misleading entries, records or documentation is strictly prohibited. You must never create a false or misleading
report or make a payment or establish an account on behalf of the Company with the understanding that any part of the payment or account is to be used for a purpose other than as described by the supporting documents. Proper record keeping is
essential to enable the Company and its officers to comply with their obligations to make full, fair, accurate, timely and understandable disclosure in the Company’s SEC filings and in other public documents. 
  
 You must provide information that is accurate, complete, objective, relevant, timely and
understandable, act in good faith, responsibly, with due care, competence and diligence without misrepresenting or omitting material facts. You must also maintain appropriate controls over all Company assets and resources that you use. You must not
take any action to fraudulently influence a public accountant who is performing an audit or review of the Company’s financial statements. You must not take any action that could result in making Company financial statements misleading.

  
 All business records and communications should be clear, truthful and
accurate. Business records and communications may become public through litigation, government investigations and the media. Employees should take care to avoid exaggeration, colorful language, guesswork, legal conclusions and derogatory remarks or
characterizations of people and other companies. This applies to communications of all kinds, including e-mail, instant messaging and “informal” notes or memos. Records should always be retained and destroyed according to the
Company’s record retention policies as discussed in this Code and as may be adopted in the future. 
  
 In the course of its business, the Company produces and receives large numbers of documents. Numerous laws require the retention of certain documents for various periods of time. The Company is committed to compliance
with all applicable laws and regulations relating to the preservation of records. The Company’s policy is to identify, maintain, safeguard and destroy or retain all records in its possession on a systematic and regular basis. Under no
circumstances are records to be destroyed selectively or to be maintained outside the Company premises or designated storage facilities, except for instances where records may be temporarily brought home by employees working from home or at a remote
location in accordance with approvals from their supervisors or applicable policies about working from home or other remote locations. If you become aware of another employee engaging in questionable behavior regarding the retention of records,
please contact the Compliance Officer. Further, the Company may adopt additional record and/or email retention policies in the future to supplement this general approach. 

	 	4.5	Computer and Communication Resources 

  
 The Company’s computer and communication resources, including computers, voicemail and email, provide substantial benefits, but they also present significant
security and liability risks to you and the Company. It is extremely important that you take all necessary measures to secure your computer and any computer or voicemail passwords. If you have any reason to believe that your password or the security
of any computer or communication resource has in any manner been compromised, you must change your password immediately and report the incident to the Compliance Officer. 
  
 When you are using Company resources to send e-mail, voicemail or to access Internet services, you are acting as a representative of the
Company. Any improper use of these resources may reflect poorly on the Company, damage its reputation, and expose you and the Company to legal liability. 
  
 All of the computing resources used to provide computing and network connections throughout the organization are the property of the Company and are intended for use by
employees to conduct the Company’s business. To the extent permitted by law, all e-mail, voicemail and personal files stored on our computers are Company property and the Company, in its sole discretion, may review any files or communications
(including e-mail and voicemail messages). Incidental and occasional personal use of electronic mail and telephones is permitted, but such use should be minimized and the length of the messages should be kept as short as possible, as these messages
cost the Company in both productive time and money. 
  

	5.	FAIR COMPETITION 

  

	 	5.1	Competitive Information 

  
 You should not employ illegal or unethical methods to obtain competitive information. For example, stealing or inducing disclosures of propriety
information by past or present employees of other companies is prohibited, as is inducing a competitor or customer to breach a contract. 
  

	 	5.2	Fair Competition and Antitrust 

  
 The Company must comply with the antitrust and unfair competition laws of the countries in which the Company does business. These laws are complex and
vary considerably from country to country. They generally concern: 
  

	 	•	Agreements with competitors that harm customers, such as agreements on price fixing or allocations of customers or contracts. 

  

	 	•	Agreements that unduly limit a customer’s ability to sell a product, such as establishing the resale price of a product or service, or conditioning the sale of products on an
agreement to buy other Company products and services. 

  

	 	•	Attempts to monopolize, such as pricing a product below cost in order to eliminate competition. 

  
 If you are unsure whether an action may violate anti-trust and fair competition laws you should consult the Company’s
Compliance Officer. 

	6.	COMMUNITIES 

  

	 	6.1	Personal Activity 

  
 Employees, officers and directors may undertake and support community, charity and political activities of their choice, as long as they make clear that
they are acting on their own as individuals, not on behalf of the Company. 
  

	 	6.2	Environment 

  
 The Company is committed to complying with all the environmental laws in all countries where the Company does business. 
  

	 	6.3	Press and Other Inquiries 

  
 Employees should forward all requests from the media in Russia to the Public Relations department and in Boston to the Company’s Compliance Officer.

  
 Employees are expected to cooperate with reasonable requests
for information from government agencies and regulators. Information so provided must be accurate. Employees should seek instructions from the Company’s Compliance Officer regarding any non-routine government information requests. No employee
shall alter or destroy documents or records in response to an investigation or other lawful information request. 
  
 Employees should forward inquiries from financial analysts and shareholders to the Company’s Compliance Officer in Boston or the public relations
department in Moscow. 
  

	7.	GOVERNMENTS 

  

	 	7.1	Compliance with the Law 

  
 Employees, officers and directors must comply with all laws and regulations wherever the Company does business. Internal or external pressures do not
justify violating the laws. 
  

	 	7.2	Political Activities 

  
 You can not make any political contribution or support in the Company’s name. 
  

	 	7.3	Anti-Corruption Laws 

  
 Each employee, officer or director must comply with the anti-corruption laws of the countries in which the Company does business, including the U.S.
Foreign Corrupt Practices Act (FCPA), which applies to the Company’s business in other countries. You can not directly or indirectly offer or give anything of value to government officials, including employees of state-owned enterprises, even
at a government official’s request. This includes, for example, entering into joint property ownership agreements, a loan, or other business arrangements with a government official. These requirements apply both to Company employees, officers,
directors and agents, no matter where they are doing business. 
  

	 	7.4	Applicable Law 

  
 Employees are responsible for knowing the laws that pertain to them, in any country where they may be working, for checking with the Company’s
Compliance Officer when in doubt, and for keeping full and accurate records in all respects as required in Records, Subsection 4.4, above. 
  

	8.	CONFLICT OF INTERESTS 

  

	 	8.1	General 

  
 You must act objectively in the best interests of the Company, not to further their own personal considerations (such as their own investments) or
relationships with family or friends. Employees must 

 avoid the appearance of impropriety as well as actual improper acts. Employees must avoid any actions which might
embarrass the Company. Employees should disclose to the Company’s Compliance Officer in advance any situation that may be, or appear to be, a conflict of interest. Conflicts of interest are prohibited as a matter of Company policy, except as
approved by the Board of Directors on a case-by-case basis. 
  

	 	8.2	Outside Employment 

  
 You may not work for or receive payments for services from any competitor, customer, supplier or agent of the Company. 
  

	 	8.3	Company Opportunities 

  
 When the Company might be interested in pursuing a business opportunity, an employee, officer or director shall not pursue it except on behalf of the
Company. Permissible exceptions are opportunities that an employee has presented to the Company, the Company has declined and the employee pursues with full disclosure to the Company and after obtaining prior written approval of the Compliance
Officer. 
  

	 	8.4	Gifts 

  
 Gifts may be of physical objects, or of services, favors or other items of value. Employees, officers or directors can not accept kickbacks, gifts (other
than small promotional type items), gratuities, or anything else that might suggest their judgments could be made on the basis of personal favoritism. 
  
 Gifts given by Company employees, officers or directors must be legal, and reasonable. Employees of many government entities around the world are
prohibited from accepting gifts. Complex rules often apply to giving gifts, including those under the US Foreign Corrupt Practices Act. No employee may pay bribes or kickbacks, directly or indirectly. 
  
 If an employee is in doubt as to whether giving or receiving a gift is legal
and reasonable, the employee should check with the Company’s Compliance Officer. Employees, officers and directors must never accept gifts or other benefits if their business judgment or decisions would be affected by, or would be perceived to
be affected by, acceptance of the gift. 
  

	 	8.5	Entertainment 

  
 You must never solicit gifts, entertainment or any other business courtesies from people doing business with the Company. You may accept unsolicited
gifts, business courtesies and entertainment that is legal, is reasonable in the context of the business, and that advances the Company’s interests. Accompanying a business associate to a local cultural or sporting event, or to a routine
business meal, is generally acceptable. But employees either must turn down offers of lavish or frequent entertainment, or pay their own way. Gifts of cash or cash equivalents (including gift certificates, securities, below-market loans, etc.) in
any amount are prohibited and must be returned promptly to the issuer. 
  
 You may provide entertainment to others that is legal and reasonable in the context of the business. 
  
 Entertainment of government officials may be prohibited by law. You should obtain advance approval from the Company’s Compliance Officer before
entertaining a government official. 
  

	 	8.6	Travel 

  
 You may accept transportation and lodging provided by a Company supplier or other third party in the course of an approved business trip. You should
accurately record what is so provided in travel expense records. 

 Unless prohibited by law or the policy of the recipient’s organization, the Company may pay for
transportation and lodging expenses of customers, agents or suppliers for a visit to a Company facility or project. The visit must be for a business purpose, like examination of equipment, contract negotiations, or training. Payments for travel by
government officials must be approved by the Company’s Compliance Officer before that travel occurs. 
  

	 	9.	Implementation of the Code 

  
 9.1 Responsibilities 
  
 While each of us
is individually responsible for putting the Code to work, we need not go it alone. The Company has a number of resources, people and processes in place to answer our questions and guide us through difficult decisions. 
  
 Copies of this Code are available from the Compliance Officer and the Human Resources
Department. This code is distributed to each employee, officer or director and a statement of compliance with the Code of Ethics and Conduct must be signed by you upon commencement of employment with the Company and on an annual basis thereafter.

  
 9.2 Seeking Guidance 
  
 This Code cannot provide definitive answers to all questions. If you have questions
regarding any of the policies discussed in this Code or if you are in doubt about the best course of action in a particular situation, you should seek guidance from your supervisor, the Compliance Officer or the other resources identified in this
Code. 
  
 9.3 Reporting Violations 
  
 If you know of or suspect a violation of applicable laws or regulations, the Code, or the
Company’s related policies, you must immediately report that information to your supervisor, the Compliance Officer or via e-mail address set provided in the whistle-blower policy. 
  
 Please do not attempt to investigate a known or suspected violation on your own; instead please report it to the appropriate individuals.

  
 9.4 Reporting Complaints and Concerns Regarding Accounting Issues

  
 The Company is committed to compliance with applicable securities laws,
rules, and regulations, accounting standards and internal accounting controls. It is the responsibility of each employee, officer and director promptly to report complaints or concerns regarding accounting, internal accounting controls and auditing
matters (“Accounting Issues”). Reports should be made to the Compliance Officer. Reports may be made anonymously. 
  
 Reports will be treated confidentially to the extent reasonably possible. No one will be subject to retaliation because of a good faith report of a complaint or concern
regarding Accounting Issues. 
  
 Employees and others may also make reports
directly to the Chairman of the Audit Committee of our Board of Directors by letter or email sent to the address specified in the whistle-blower policy. 
  
 9.5 Treatment of Complaints and Retention of Records Regarding Accounting Issues 
  
 Reports of concerns or complaints regarding Accounting Issues will be investigated in accordance with Company policy as outlined in the
whistle-blower policy adopted by the Company and available upon request from the Compliance Officer or Human Resources department. 

 9.6 No Retaliation 
  
 The Company will not retaliate in any manner, including, but not limited to, discharging, demoting, suspending, threatening, harassing, or otherwise discriminating
against an employee who reports in good faith violations or suspected violations of this Code, including, but not limited to, accounting fraud or securities law violations. Retaliation against any person for providing information or otherwise
assisting in an investigation or proceeding regarding any conduct that the employee believes constitutes a violation of applicable laws or regulations, the Code or any other Company policy is strictly prohibited and may result in disciplinary
action, up to and including termination of employment. Any suspected act of retaliation should be reported to the Compliance Officer or your supervisor immediately. 
  
 9.7 Discipline for Violations 
  
 This Code will be enforced at all levels, fairly and without prejudice. 
  
 The Company intends to use every reasonable effort to prevent the occurrence of conduct not in compliance with its Code and to halt any such conduct that may occur as
soon as reasonably possible after its discovery. Subject to applicable law, officers, directors and employees who violate this Code and other Company policies and procedures may be subject to disciplinary actions, up to and including termination of
employment and, if warranted, civil legal action or referral to criminal prosecution. In addition, subject to applicable law, disciplinary actions, up to and including termination of employment, may be taken against anyone who directs or approves
infractions or has knowledge of them and does not promptly report them in accordance with our policies.

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