Document:

EX-4.2

 Exhibit 4.2 

XERIS PHARMACEUTICALS, INC. 

and 
 U.S. BANK NATIONAL
ASSOCIATION 
 as Trustee 
  

 
 FIRST SUPPLEMENTAL INDENTURE 

Dated as of June 30, 2020 
  

 
 5.00% Convertible Senior Notes due
2025 

 TABLE OF CONTENTS 

 

					
	 Article 1. DEFINITIONS; RULES OF CONSTRUCTION
	  	 	1	 
		
	 Section 1.01. Definitions
	  	 	1	 
		
	 Section 1.02. Other Definitions
	  	 	6	 
		
	 Section 1.03. Rules of Construction
	  	 	8	 
		
	 Section 1.04. Interpretation; Scope of Supplemental Indenture; Supersession of Base
Indenture
	  	 	9	 
		
	 Article 2. THE NOTES
	  	 	9	 
		
	 Section 2.01. Form, Dating and Denominations
	  	 	9	 
		
	 Section 2.02. Execution, Authentication and Delivery
	  	 	10	 
		
	 Section 2.03. Initial Notes and Additional Notes
	  	 	10	 
		
	 Section 2.04. Method of Payment
	  	 	10	 
		
	 Section 2.05. Accrual of Interest; Defaulted Amounts; When Payment Date is Not a Business
Day
	  	 	11	 
		
	 Section 2.06. Registrar, Paying Agent and Conversion Agent
	  	 	11	 
		
	 Section 2.07. Paying Agent and Conversion Agent to Hold Property in Trust
	  	 	12	 
		
	 Section 2.08. Holder Lists
	  	 	12	 
		
	 Section 2.09. Legends
	  	 	12	 
		
	 Section 2.10. Transfers and Exchanges; Certain Transfer Restrictions
	  	 	12	 
		
	 Section 2.11. Exchange and Cancellation of Notes to Be Converted or to Be Repurchased
Pursuant to a Repurchase Upon Fundamental Change or Redemption
	  	 	15	 
		
	 Section 2.12. Replacement Notes
	  	 	15	 
		
	 Section 2.13. Registered Holders; Certain Rights with Respect to Global Notes
	  	 	15	 
		
	 Section 2.14. Cancellation
	  	 	16	 
		
	 Section 2.15. Notes Held by the Company or its Affiliates
	  	 	16	 
		
	 Section 2.16. Temporary Notes
	  	 	16	 
		
	 Section 2.17. Outstanding Notes
	  	 	16	 
		
	 Section 2.18. Repurchases by the Company
	  	 	17	 
		
	 Section 2.19. CUSIP and ISIN Numbers
	  	 	17	 

					
	 Article 3. COVENANTS
	  	 	17	 
		
	 Section 3.01. Payment on Notes
	  	 	17	 
		
	 Section 3.02. Exchange Act Reports
	  	 	17	 
		
	 Section 3.03. Compliance and Default Certificates
	  	 	17	 
		
	 Section 3.04. Stay, Extension and Usury Laws
	  	 	18	 
		
	 Section 3.05. Corporate Existence
	  	 	18	 
		
	 Section 3.06. Acquisition of Notes by the Company and its Affiliates
	  	 	18	 
		
	 Section 3.07. Further Instruments and Acts
	  	 	18	 
		
	 Article 4. REPURCHASE AND REDEMPTION
	  	 	18	 
		
	 Section 4.01. No Sinking Fund
	  	 	18	 
		
	 Section 4.02. Right of Holders to Require the Company to Repurchase Notes upon a Fundamental
Change
	  	 	18	 
		
	 Section 4.03. Right of the Company to Redeem the Notes
	  	 	21	 
		
	 Article 5. CONVERSION
	  	 	23	 
		
	 Section 5.01. Right to Convert
	  	 	23	 
		
	 Section 5.02. Conversion Procedures
	  	 	23	 
		
	 Section 5.03. Settlement upon Conversion
	  	 	24	 
		
	 Section 5.04. Reserve and Status of Common Stock Issued upon Conversion
	  	 	25	 
		
	 Section 5.05. Adjustments to the Conversion Rate
	  	 	25	 
		
	 Section 5.06. Voluntary Adjustments
	  	 	31	 
		
	 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental
Change
	  	 	31	 
		
	 Section 5.08. Effect of Common Stock Change Event
	  	 	32	 
		
	 Section 5.09. Limits Upon Issuance of Shares of Common Stock Upon Conversion
	  	 	33	 
		
	 Article 6. SUCCESSORS
	  	 	34	 
		
	 Section 6.01. When the Company May Merge, Etc.
	  	 	34	 
		
	 Section 6.02. Successor Corporation Substituted
	  	 	35	 

					
	 Article 7. DEFAULTS AND REMEDIES
	  	 	35	 
		
	 Section 7.01. Events of Default
	  	 	35	 
		
	 Section 7.02. Acceleration
	  	 	36	 
		
	 Section 7.03. Sole Remedy for a Failure to Report
	  	 	37	 
		
	 Section 7.04. Other Remedies
	  	 	37	 
		
	 Section 7.05. Waiver of Past Defaults
	  	 	38	 
		
	 Section 7.06. Control by Majority
	  	 	38	 
		
	 Section 7.07. Limitation on Suits
	  	 	38	 
		
	 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to
Receive Payment and Conversion Consideration
	  	 	38	 
		
	 Section 7.09. Collection Suit by Trustee
	  	 	38	 
		
	 Section 7.10. Trustee May File Proofs of Claim
	  	 	39	 
		
	 Section 7.11. Priorities
	  	 	39	 
		
	 Section 7.12. Undertaking for Costs
	  	 	39	 
		
	 Section 7.13. Trustee’s Obligation to Provide Notice of Defaults to Holders
	  	 	39	 
		
	 Article 8. AMENDMENTS, SUPPLEMENTS AND WAIVERS
	  	 	40	 
		
	 Section 8.01. Without the Consent of Holders
	  	 	40	 
		
	 Section 8.02. With the Consent of Holders
	  	 	40	 
		
	 Section 8.03. Notice of Amendments, Supplements and Waivers
	  	 	41	 
		
	 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates;
Etc.
	  	 	41	 
		
	 Section 8.05. Notations and Exchanges
	  	 	41	 
		
	 Section 8.06. Trustee to Execute Supplemental Indentures
	  	 	42	 
		
	 Article 9. SATISFACTION AND DISCHARGE
	  	 	42	 
		
	 Section 9.01. Termination of Company’s Obligations
	  	 	42	 
		
	 Section 9.02. Repayment to Company
	  	 	42	 
		
	 Section 9.03. Reinstatement
	  	 	42	 

					
	 Article 10. TRUSTEE
	  	 	43	 
		
	 Section 10.01. Duties of the Trustee
	  	 	43	 
		
	 Section 10.02. Rights of the Trustee
	  	 	44	 
		
	 Section 10.03. Individual Rights of the Trustee
	  	 	44	 
		
	 Section 10.04. Trustee’s Disclaimer
	  	 	45	 
		
	 Section 10.05. Notice of Defaults
	  	 	45	 
		
	 Section 10.06. Compensation and Indemnity
	  	 	45	 
		
	 Section 10.07. Replacement of the Trustee
	  	 	45	 
		
	 Section 10.08. Successor Trustee by Merger, Etc.
	  	 	46	 
		
	 Section 10.09. Eligibility; Disqualification
	  	 	46	 
		
	 Article 11. MISCELLANEOUS
	  	 	46	 
		
	 Section 11.01. Notices
	  	 	46	 
		
	 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions
Precedent
	  	 	47	 
		
	 Section 11.03. Statements Required in Officer’s Certificate and Opinion of
Counsel
	  	 	48	 
		
	 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent
	  	 	48	 
		
	 Section 11.05. No Personal Liability of Directors, Officers, Employees and
Stockholders
	  	 	48	 
		
	 Section 11.06. Governing Law; Waiver of Jury Trial
	  	 	48	 
		
	 Section 11.07. Submission to Jurisdiction
	  	 	48	 
		
	 Section 11.08. No Adverse Interpretation of Other Agreements
	  	 	49	 
		
	 Section 11.09. Successors
	  	 	49	 
		
	 Section 11.10. Force Majeure
	  	 	49	 
		
	 Section 11.11. U.S.A. PATRIOT Act
	  	 	49	 
		
	 Section 11.12. Calculations
	  	 	49	 
		
	 Section 11.13. Severability
	  	 	49	 

					
	 Section 11.14. Counterparts
	  	 	49	 
		
	 Section 11.15. Table of Contents, Headings, Etc.
	  	 	49	 
		
	 Section 11.16. Withholding Taxes
	  	 	50	 
		
	 Section 11.17. Trust Indenture Act Controls
	  	 	50	 

 Exhibits 
  

			
	Exhibit A: Form of Note	  	A-1
		
	Exhibit B: Form of Global Note Legend	  	B-1

 FIRST SUPPLEMENTAL INDENTURE, dated as of June 30, 2020, between Xeris
Pharmaceuticals, Inc., a Delaware corporation, as issuer (the “Company”), and U.S. Bank National Association, as trustee (the “Trustee”). 

This Supplemental Indenture (as defined below) is being executed and delivered pursuant to Sections 2.01 and 2.02 of the Base Indenture (as
defined below) to establish the terms, and provide for the issuance, of a new series of Securities (as defined in the Base Indenture) constituting the Company’s 5.00% Convertible Senior Notes due 2025 (the “Notes”). 

Each party to this Supplemental Indenture agrees as follows for the benefit of the other party and for the equal and ratable benefit of the
Holders (as defined below) of the Notes. 
 Article 1. DEFINITIONS; RULES OF CONSTRUCTION 

Section 1.01. DEFINITIONS. 

Subject to the last paragraph of Section 1.03, capitalized terms used in this Supplemental Indenture without definition have the
respective meanings ascribed to them in the Base Indenture. For purposes of the Notes, the following additional definitions will apply and supersede any conflicting definitions in the Base Indenture. 

“Affiliate” has the meaning set forth in Rule 144 as in effect on the Issue Date, except that for purposes of
Section 5.09 only, “Affiliate” shall have meaning specified in Section 5.09. 
 “Associate” shall have
meaning specified in Section 5.09. 
 “Authorized Denomination” means, with respect to a Note, a principal amount
thereof equal to $1,000 or any integral multiple of $1,000 in excess thereof. 
 “Bankruptcy Law” means Title 11, United
States Code, or any similar U.S. federal or state or non-U.S. law for the relief of debtors. 

“Beneficial Owner” shall have the meaning specified in Section 5.09. 

“Beneficial Ownership Limits” shall have the meaning specified in Section 5.09(B). 

“Base Indenture” means that certain Indenture, dated as of June 30, 2020, between the Company and the Trustee. 

“Board of Directors” means the board of directors of the Company or a committee of such board duly authorized to act on
behalf of such board. 
 “Business Day” means any day other than a Saturday, a Sunday or any day on which the Federal
Reserve Bank of New York (or, for purposes of Section 2.05(C), the applicable place of payment) is authorized or required by law or executive order to close or be closed. 

“Capital Stock” of any Person means any and all shares of, interests in, rights to purchase, warrants or options for,
participations in, or other equivalents of, in each case however designated, the equity of such Person, but excluding any debt securities convertible into such equity. 

“Close of Business” means 5:00 p.m., New York City time. 

“Common Stock” means the common stock, $0.001 par value per share, of the Company, subject to Section 5.08. 

“Company” means the Person named as such in the first paragraph of the Supplemental Indenture and, subject to Article 6, its
successors and assigns. 
 “Company Order” means a written request or order signed on behalf of the Company by one
(1) of its Officers and delivered to the Trustee. 

  
 1 

 “Conversion Date” means, with respect to a Note, the first Business Day on
which the requirements set forth in Section 5.02(A) to convert such Note are satisfied. 
 “Conversion
Price” means, as of any time, an amount equal to (A) one thousand dollars ($1,000) divided by (B) the Conversion Rate in effect at such time. 

“Conversion Rate” initially means 326.7974 shares of Common Stock per $1,000 principal amount of
Notes; provided, however, that the Conversion Rate is subject to adjustment pursuant to Article 5; provided, further, that whenever the Indenture refers to the Conversion Rate as of a particular date
without setting forth a particular time on such date, such reference will be deemed to be to the Conversion Rate immediately after the Close of Business on such date. 

“Conversion Share” means any share of Common Stock issued or issuable upon conversion of any Note. 

“Default” means any event that is (or, after notice, passage of time or both, would be) an Event of Default. 

“Depositary” means The Depository Trust Company or its successor. 

“Depositary Participant” means any member of, or participant in, the Depositary. 

“Depositary Procedures” means, with respect to any conversion, transfer, exchange or transaction involving a Global Note or
any beneficial interest therein, the rules and procedures of the Depositary applicable to such conversion, transfer, exchange or transaction. 

“Ex-Dividend Date” means, with respect to an issuance, dividend or distribution on
the Common Stock, the first date on which shares of Common Stock trade on the applicable exchange or in the applicable market, regular way, without the right to receive such issuance, dividend or distribution (including pursuant to due bills or
similar arrangements required by the relevant stock exchange). For the avoidance of doubt, any alternative trading convention on the applicable exchange or market in respect of the Common Stock under a separate ticker symbol or CUSIP number will not
be considered “regular way” for this purpose. 
 “Exchange Act” means the U.S. Securities Exchange Act of 1934,
as amended. 
 “Fundamental Change” means any of the following events: 

(A) a “person” or “group” (within the meaning of Section 13(d)(3) of the Exchange Act), other than the Company or
any of its Wholly Owned Subsidiaries, or their respective employee benefit plans, has become and files any report with the SEC that discloses that such person or group, has become the direct or indirect “beneficial owner” (as defined
below) of shares of the Common Stock representing more than fifty percent (50%) of the voting power of all of the Company’s then-outstanding Common Stock; provided, however, that, for these purposes, no “person” or “group”
will be deemed to be the beneficial owner of any securities tendered pursuant to a tender or exchange offer made by or on behalf of such “person” or “group” until such tendered securities are accepted for purchase or exchange
under such offer; 
 (B) the consummation of (i) any sale, lease or other transfer, in one transaction or a series of transactions,
of all or substantially all of the assets of the Company and its Subsidiaries, taken as a whole, to any Person, other than one or more of the Company’s Wholly Owned Subsidiaries; or (ii) any transaction or series of related transactions in
connection with which (whether by means of merger, consolidation, share exchange, combination, reclassification, recapitalization, acquisition, liquidation or otherwise) all of the Common Stock is exchanged for, converted into, acquired for, or
constitutes solely the right to receive, other securities, cash or other property (other than changes resulting solely from a subdivision or combination, or a change in par value, of the Company’s Common Stock); provided, however, that any
merger, consolidation, share exchange, combination, reclassification or recapitalization of the Company pursuant to which the Persons that directly or indirectly “beneficially owned” (as defined below) all classes of the Company’s
common equity immediately before such transaction directly or indirectly “beneficially own,” immediately after such transaction, more than fifty percent (50%) of all classes of common equity of the surviving, continuing or acquiring
company or other transferee, as applicable, or the parent thereof, in substantially the same proportions vis-à-vis each other as immediately before such
transaction will be deemed not to be a Fundamental Change pursuant to this clause (B); 
 (C) the Company’s stockholders approve
any plan or proposal for the liquidation or dissolution of the Company; or 

  
 2 

 (D) the Common Stock ceases to be listed on any of The New York Stock Exchange, The
NYSE American, The NASDAQ Capital Market, The NASDAQ Global Market or The NASDAQ Global Select Market (or any of their respective successors); 

provided, however, that a transaction or event described in clause (A) or (B) above will not constitute a Fundamental Change if at
least ninety percent (90%) of the consideration received or to be received by the holders of Common Stock (excluding cash payments for fractional shares or pursuant to dissenters rights), in connection with such transaction or event, consists of
shares of common stock listed on any of The New York Stock Exchange, The NYSE American, The NASDAQ Capital Market, The NASDAQ Global Market or The NASDAQ Global Select Market (or any of their respective successors), or that will be so listed when
issued or exchanged in connection with such transaction or event, and such transaction or event constitutes a Common Stock Change Event whose Reference Property consists of such consideration. 

For the purposes of this definition, (x) any transaction or event that constitutes a Fundamental Change pursuant to both clause
(A) and clause (B) above (without regard to the proviso in clause (B)) will be deemed to occur solely pursuant to clause (B) above (subject to such proviso); and (y) whether a Person is a “beneficial owner” and
whether shares are “beneficially owned” will be determined in accordance with Rule 13d-3 under the Exchange Act, subject to the proviso to clause (A) above. 

“Fundamental Change Repurchase Date” means the date fixed for the repurchase of any Notes by the Company pursuant to a
Repurchase Upon Fundamental Change. 
 Fundamental Change Repurchase Notice” means a notice (including a notice substantially in
the form of the “Fundamental Change Repurchase Notice” set forth in Exhibit A) containing the information, or otherwise complying with the requirements, set forth in Section 4.02(F)(i)
and Section 4.02(F)(ii). 
 “Fundamental Change Repurchase Price” means the cash price payable by
the Company to repurchase any Note upon its Repurchase Upon Fundamental Change, calculated pursuant to Section 4.02(D). 

“General Beneficial Ownership Limit” shall have the meaning specified in Section 5.09(A). 

“Global Note” means a Note that is represented by a certificate substantially in the form set forth in Exhibit A,
registered in the name of the Depositary or its nominee, duly executed by the Company and authenticated by the Trustee, and deposited with the Trustee, as custodian for the Depositary. 

“Global Note Legend” means a legend substantially in the form set forth in Exhibit
B-2. 
 “Holder” means a person in whose name a Note is registered on the
Registrar’s books. 
 “Holder Beneficial Ownership Limit” shall have the meaning specified in Section 5.09(B).

 “Indenture” means the Base Indenture, as amended by this Supplemental Indenture, and as the same may be further amended
or supplemented from time to time with respect to the Notes. 
 “Interest Payment Date” means, with respect to a Note, each
January 15 and July 15 of each year, commencing on January 15, 2021 (or commencing on such other date specified in the certificate representing such Note). For the avoidance of doubt, the Maturity Date is an Interest Payment Date.

 “Issue Date” means June 30, 2020. 

“Last Reported Sale Price” of the Common Stock for any Trading Day means the closing sale price per share (or, if no closing
sale price is reported, the average of the last bid price and the last ask price per share or, if more than one in either case, the average of the average last bid prices and the average last ask prices per share) of Common Stock on such Trading Day
as reported in composite transactions for the principal U.S. national or regional securities exchange on which the Common Stock is then listed. If the Common Stock is not listed on a U.S. national or regional securities exchange on such Trading Day,
then the Last Reported Sale Price will be the last quoted bid price per share of Common Stock on such Trading Day in the over-the-counter market as reported by OTC
Markets Group Inc. or a similar organization. If the Common Stock is not so quoted on such Trading Day, then the Last Reported Sale Price will be the average of the mid-point of the last bid price and the last
ask price per share of Common Stock on such Trading Day from each of at least three (3) nationally recognized independent investment banking firms selected by the Company, which may include any of the Underwriters. The Last Reported Sale Price
will be determined without regard to after-hours trading or any other trading outside of the regular trading session hours. Neither the Trustee nor the Conversion Agent will have any duty to determine the Last Reported Sale Price. 

  
 3 

 “Make-Whole Fundamental Change” means (A) a Fundamental Change
(determined after giving effect to the proviso immediately after clause (D) of the definition thereof, but without regard to the proviso to clause (B)(ii) of such definition); or (B) the sending of a Redemption Notice pursuant
to Section 4.03(F). 
 “Make-Whole Fundamental Change Conversion Period” has the following meaning: 

(A) in the case of a Make-Whole Fundamental Change pursuant to clause (A) of the definition thereof, the period from, and including,
the Make-Whole Fundamental Change Effective Date of such Make-Whole Fundamental Change to, and including, the thirty fifth (35th) Trading Day after such Make-Whole Fundamental Change Effective Date (or, if such Make-Whole Fundamental Change (other
than an Exempted Fundamental Change) also constitutes a Fundamental Change, to, but excluding, the Close of Business on the Business Day immediately preceding the related Fundamental Change Repurchase Date); and 

(B) in the case of a Make-Whole Fundamental Change pursuant to clause (B) of the definition thereof, the period from, and including,
the Redemption Notice Date for the related Redemption to, and including, the Close of Business on the second Business Day immediately before the related Redemption Date; 

provided, however, that if the Conversion Date for the conversion of a Note occurs during the Make-Whole Fundamental Change Conversion Period for both a
Make-Whole Fundamental Change occurring pursuant to clause (A) of the definition of “Make-Whole Fundamental Change” and a Make-Whole Fundamental Change occurring pursuant to clause (B) of such definition, then, solely for
purposes of such conversion, (x) such Conversion Date will be deemed to occur solely during the Make-Whole Fundamental Change Conversion Period for the Make-Whole Fundamental Change with the earlier Make-Whole Fundamental Change Effective Date;
and (y) the Make-Whole Fundamental Change with the later Make-Whole Fundamental Change Effective Date will be deemed not to have occurred. 

“Make-Whole Fundamental Change Effective Date” means (A) with respect to a Make-Whole Fundamental Change pursuant to
clause (A) of the definition thereof, the date on which such Make-Whole Fundamental Change occurs or becomes effective; and (B) with respect to a Make-Whole Fundamental Change pursuant to clause (B) of the definition thereof, the
applicable Redemption Notice Date. 
 “Market Disruption Event” means, with respect to any date, the occurrence or
existence, during the one-half hour period ending at the scheduled close of trading on such date on the principal U.S. national or regional securities exchange or other market on which the Common Stock is
listed for trading or trades, of any material suspension or limitation imposed on trading (by reason of movements in price exceeding limits permitted by the relevant exchange or otherwise) in the Common Stock or in any options contracts or futures
contracts relating to the Common Stock. 
 “Maturity Date” means July 15, 2025. 

“Note Agent” means any Registrar, Paying Agent or Conversion Agent. 

“Notes” means the 5.00% Convertible Senior Notes due 2025 issued by the Company pursuant to the Indenture. 

“Officer” means the Chairman of the Board of Directors, the Chief Executive Officer, the President, the Chief Operating
Officer, the Chief Financial Officer, the Treasurer, any Assistant Treasurer, the Controller, the Secretary or any Vice-President of the Company. 

“Officer’s Certificate” means a certificate that is signed on behalf of the Company by one (1) of its
Officers and that meets the requirements of Section 11.03. 
 “Open of Business” means 9:00 a.m., New York City
time. 
 “Opinion of Counsel” means an opinion, from legal counsel who is reasonably acceptable to the Trustee, that meets
the requirements of Section 11.03, subject to customary qualifications and exclusions. 
 “Person” or
“person” means any individual, corporation, partnership, limited liability company, joint venture, association, joint-stock company, trust, unincorporated organization or government or other agency or political subdivision thereof.
Any division or series of a limited liability company, limited partnership or trust will constitute a separate “person” under the Indenture. 

  
 4 

 “Physical Note” means a Note (other than a Global Note) that is represented
by a certificate substantially in the form set forth in Exhibit A, registered in the name of the Holder of such Note and duly executed by the Company and authenticated by the Trustee. 

“Redemption” means the repurchase of any Note by the Company pursuant to Section 4.03. 

“Redemption Date” means the date fixed, pursuant to Section 4.03(D), for the settlement of the repurchase
of any Notes by the Company pursuant to a Redemption. 
 “Redemption Notice Date” means, with respect to a Redemption, the
date on which the Company sends the Redemption Notice for such Redemption pursuant to Section 4.03(F). 

“Redemption Price” means the cash price payable by the Company to redeem any Note upon its Redemption, calculated pursuant
to Section 4.03(E). 
 “Regular Record Date” has the following meaning with respect to an Interest
Payment Date: (A) if such Interest Payment Date occurs on January 15, the immediately preceding January 1; and (B) if such Interest Payment Date occurs on July 15, the immediately preceding July 1. 

“Repurchase Upon Fundamental Change” means the repurchase of any Note by the Company pursuant to Section 4.02.

 “Responsible Officer” means (A) any officer within the Corporate Trust Administration of the Trustee (or any
successor group of the Trustee) or any other officer of the Trustee customarily performing functions similar to those performed by any of such officers; and (B) with respect to a particular corporate trust matter relating to the Indenture, any
other officer to whom such matter is referred because of his or her knowledge of, and familiarity with, the particular subject, and who, in each case, shall have direct responsibility for the administration of the Indenture. 

“Rule 144” means Rule 144 under the Securities Act (or any successor rule thereto), as the same may be amended from time to
time. 
 “Scheduled Trading Day” means any day that is scheduled to be a Trading Day on the principal U.S. national or
regional securities exchange on which the Common Stock is then listed or, if the Common Stock is not then listed on a U.S. national or regional securities exchange, on the principal other market on which the Common Stock is then traded. If the
Common Stock is not so listed or traded, then “Scheduled Trading Day” means a Business Day. 
 “SEC” means the
U.S. Securities and Exchange Commission. 
 “Securities Act” means the U.S. Securities Act of 1933, as amended. 

“Security” means any Note or Conversion Share. 

“Significant Subsidiary” means, with respect to any Person, any Subsidiary of such Person that constitutes, or any group of
Subsidiaries of such Person that, in the aggregate, would constitute, a “significant subsidiary” (as defined in Rule 1-02(w) of Regulation S-X under the
Exchange Act) of such Person. 
 “Special Interest” means any interest that accrues on any Note pursuant to Section
7.03. 
 “Stock Price” has the following meaning for any Make-Whole Fundamental Change: (A) if the holders of
Common Stock receive only cash in consideration for their shares of Common Stock in such Make-Whole Fundamental Change and such Make-Whole Fundamental Change is pursuant to clause (B) of the definition of “Fundamental Change,” then
the Stock Price is the amount of cash paid per share of Common Stock in such Make-Whole Fundamental Change; and (B) in all other cases, the Stock Price is the average of the Last Reported Sale Prices per share of Common Stock for the five
(5) consecutive Trading Days ending on, and including, the Trading Day immediately before the Make-Whole Fundamental Change Effective Date of such Make-Whole Fundamental Change. 

  
 5 

 “Subsidiary” means, with respect to any Person, (A) any corporation,
association or other business entity (other than a partnership or limited liability company) of which more than fifty percent (50%) of the total voting power of the Capital Stock entitled (without regard to the occurrence of any contingency, but
after giving effect to any voting agreement or stockholders’ agreement that effectively transfers voting power) to vote in the election of directors, managers or trustees, as applicable, of such corporation, association or other business entity
is owned or controlled, directly or indirectly, by such Person or one or more of the other Subsidiaries of such Person; and (B) any partnership or limited liability company where (i) more than fifty percent (50%) of the capital accounts,
distribution rights, equity and voting interests, or of the general and limited partnership interests, as applicable, of such partnership or limited liability company are owned or controlled, directly or indirectly, by such Person or one or more of
the other Subsidiaries of such Person, whether in the form of membership, general, special or limited partnership or limited liability company interests or otherwise; and (ii) such Person or any one or more of the other Subsidiaries of such
Person is a controlling general partner of, or otherwise controls, such partnership or limited liability company. 
 “Supplemental
Indenture” means this First Supplemental Indenture, as amended or supplemented from time to time. 
 “Trading Day”
means any day on which (A) trading in the Common Stock generally occurs on the principal U.S. national or regional securities exchange on which the Common Stock is then listed or, if the Common Stock is not then listed on a U.S. national or
regional securities exchange, on the principal other market on which the Common Stock is then traded; and (B) there is no Market Disruption Event. If the Common Stock is not so listed or traded, then “Trading Day” means a Business
Day. 
 “Trust Indenture Act” means the U.S. Trust Indenture Act of 1939, as amended. 

“Trustee” means the Person named as such in the first paragraph of the Indenture until a successor replaces it in accordance
with the provisions of the Indenture and, thereafter, means such successor. 
 “Underwriters” means Jefferies LLC and SVB
Leerink LLC. 
 “Underwriting Agreement” means that certain Underwriting Agreement by and among the Underwriters and the
Company, dated as of June 25, 2020. 
 “Wholly Owned Subsidiary” of a Person means any Subsidiary of such Person all
of the outstanding Capital Stock or other ownership interests of which (other than directors’ qualifying shares) are owned by such Person or one or more Wholly Owned Subsidiaries of such Person. 

Section 1.02. OTHER DEFINITIONS. 

  
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	 Term
	  	 Defined in

Section

		
	“Additional Shares”	  	5.07(A)
		
	“Business Combination Event”	  	6.01(A)
		
	“Common Stock Change Event”	  	5.08(A)
		
	“Conversion Agent”	  	2.06(A)
		
	“Conversion Consideration”	  	5.03(A)
		
	“Default Interest”	  	2.05(B)
		
	“Defaulted Amount”	  	2.05(B)
		
	“Event of Default”	  	7.01(A)
		
	“Exempted Fundamental Change”	  	4.02(K)(i)(2)
		
	“Expiration Date”	  	5.05(A)(v)
		
	“Expiration Time”	  	5.05(A)(v)
		
	“Fundamental Change Notice”	  	4.02(E)
		
	“Fundamental Change Repurchase Right”	  	4.02(A)
		
	“Initial Notes”	  	2.03(A)
		
	“Paying Agent”	  	2.06(A)
		
	“Redemption Notice”	  	4.03(F)

  
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	 Term
	  	 Defined in

Section

		
	“Reference Property”	  	5.08(A)
		
	“Reference Property Unit”	  	5.08(A)
		
	“Register”	  	2.06(B)
		
	“Registrar”	  	2.06(A)
		
	“Reporting Event of Default”	  	7.03(A)
		
	“Specified Courts”	  	11.07
		
	“Spin-Off”	  	5.05(A)(iii)(2)
		
	“Spin-Off Valuation Period”	  	5.05(A)(iii)(2)
		
	“Stated Interest”	  	2.05(A)
		
	“Successor Corporation”	  	6.01(A)
		
	“Successor Person”	  	5.08(A)
		
	“Tender/Exchange Offer Valuation Period”	  	5.05(A)(v)

 Section 1.03. RULES OF CONSTRUCTION. 

For purposes of the Indenture: 

(A) “or” is not exclusive; 

(B) “including” means “including without limitation”; 

(C) “will” expresses a command; 

(D) the “average” of a set of numerical values refers to the arithmetic average of such numerical values; 

(E) a merger involving, or a transfer of assets by, a limited liability company, limited partnership or trust will be deemed to include
any division of or by, or an allocation of assets to a series of, such limited liability company, limited partnership or trust, or any unwinding of any such division or allocation; 

(F) words in the singular include the plural and in the plural include the singular, unless the context requires otherwise; 

(G) “herein,” “hereof” and other words of similar import refer to the Indenture as a whole and not to any particular
Article, Section or other subdivision of the Indenture, unless the context requires otherwise; 

  
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 (H) each Article, Section, clause or paragraph reference in this Supplemental Indenture
that is in bolded typeface refers to the referenced Article, Section, clause or paragraph, as applicable, of this Supplemental Indenture; 

(I) references to currency mean the lawful currency of the United States of America, unless the context requires otherwise; 

(J) the exhibits, schedules and other attachments to this Supplemental Indenture are deemed to form part of the Indenture; and 

(K) the term “interest,” when used with respect to a Note, includes any Special Interest, unless the context requires
otherwise. 
 For purposes of the Indenture, the following terms of the Trust Indenture Act have the following meanings: 

(i) “Commission” means the SEC; 

(ii) “indenture securities” means the Notes; 

(iii) “indenture security holder” means a Holder; 

(iv) “indenture to be qualified” means the Indenture; 

(v) “indenture trustee” or “institutional trustee” means the Trustee; and 

(vi) “obligor” on the indenture securities means the Company. 

All other terms used in the Indenture that are defined by the Trust Indenture Act (including by reference to another statute) or the related
rules of the SEC, and not defined in the Indenture, have the respective meanings so defined by the Trust Indenture Act or such rules. 

Section 1.04. Interpretation; Scope of Supplemental Indenture; Supersession of Base Indenture. 

The amendments to the Base Indenture made by this Supplemental Indenture will apply solely with respect to the Notes and not with respect to
any other class or series of Securities unless a supplemental indenture with respect to such other Securities specifically incorporates such amendments. For purposes of the Notes, if any provision of this Supplemental Indenture conflicts with any
provision of the Base Indenture, then this Supplemental Indenture will control to the extent of such conflict, and, for the avoidance of doubt, the following provisions of the Base Indenture will not apply to the Notes: Articles 2 (other than
Sections 2.01 and 2.02), 3, 4, 6, 9, 10, 11 and 13. 
 Article 2. THE NOTES 

Section 2.01. Form, Dating and Denominations. 

The Notes and the Trustee’s certificate of authentication will be substantially in the form set forth in Exhibit A. The Notes
will bear the legends required by Section 2.09 and may bear notations, legends or endorsements required by law, stock exchange rule or usage or the Depositary. Each Note will be dated as of the date of its authentication. 

Except to the extent otherwise provided in a Company Order delivered to the Trustee in connection with the issuance and authentication
thereof, the Notes will be issued initially in the form of one or more Global Notes. Global Notes may be exchanged for Physical Notes, and Physical Notes may be exchanged for Global Notes, only as provided in Section 2.10. 

The Notes will be issuable only in registered form without interest coupons and only in Authorized Denominations. 

Each certificate representing a Note will bear a unique registration number that is not affixed to any other certificate representing another
outstanding Note. 

  
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 The terms contained in the Notes constitute part of the Indenture, and, to the extent
applicable, the Company and the Trustee, by their execution and delivery of the Indenture, agree to such terms and to be bound thereby; provided, however, that, to the extent that any provision of any Note conflicts with the
provisions of the Indenture, the provisions of the Indenture will control for purposes of the Indenture and such Note. 
 Section 2.02. Execution,
Authentication and Delivery. 
 (A) Due Execution by the Company. At least one (1) duly authorized Officer will
sign the Notes on behalf of the Company by manual, electronic (i.e. “. pdf”) or facsimile signature. A Note’s validity will not be affected by the failure of any Officer whose signature is on any Note to hold, at
the time such Note is authenticated, the same or any other office at the Company. 
 (B) Authentication by the Trustee and Delivery.

 (i) No Note will be valid until it is authenticated by the Trustee. A Note will be deemed to be duly authenticated only when an
authorized signatory of the Trustee (or a duly appointed authenticating agent) signs the certificate of authentication of such Note by manual signature. 

(ii) The Trustee will cause an authorized signatory of the Trustee (or a duly appointed authenticating agent) to manually sign the
certificate of authentication of a Note only if (1) the Company delivers such Note to the Trustee; (2) such Note is executed by the Company in accordance with Section 2.02(A); and (3) the Company delivers a Company
Order to the Trustee that (a) requests the Trustee to authenticate such Note; and (b) sets forth the name of the Holder of such Note and the date as of which such Note is to be authenticated. If such Company Order also requests the Trustee
to deliver such Note to any Holder or to the Depositary, then the Trustee will promptly deliver such Note in accordance with such Company Order. 

(iii) The Trustee may appoint an authenticating agent acceptable to the Company to authenticate Notes. A duly appointed authenticating
agent may authenticate Notes whenever the Trustee may do so under the Indenture, and a Note authenticated as provided in the Indenture by such an agent will be deemed, for purposes of the Indenture, to be authenticated by the Trustee. Each duly
appointed authenticating agent will have the same rights to deal with the Company as the Trustee would have if it were performing the duties that the authentication agent was validly appointed to undertake. 

Section 2.03. Initial Notes and Additional Notes. 

(A) Initial Notes. The aggregate principal amount of Notes that may be authenticated and delivered under this Supplemental
Indenture is initially limited to seventy-five million dollars ($75,000,000) (such Notes, as increased by an amount equal to the aggregate principal amount of any additional Notes purchased by the Underwriters pursuant to the exercise of their
option to purchase additional Notes as set forth in the Underwriting Agreement, together with any Notes issued in exchange therefor or in substitution thereof, are referred to in the Indenture as the “Initial Notes”). 

(B) Additional Notes. The Company may, subject to the provisions of the Indenture (including Section 2.02),
originally issue additional Notes with the same terms as the Initial Notes (except, to the extent applicable, with respect to the date as of which interest begins to accrue on such additional Notes and the first Interest Payment Date of such
additional Notes), which additional Notes will, subject to the foregoing, be considered to be part of the same series of, and rank equally and ratably with all other, Notes issued under the Indenture; provided, however, that
if any such additional Notes are not fungible with other Notes issued under the Indenture for federal income tax or federal securities laws purposes, then such additional Notes will be identified by a separate CUSIP number or by no CUSIP number.

 Section 2.04. Method of Payment 

(A) Global Notes. The Company will pay, or cause the Paying Agent to pay, the principal (whether due upon maturity on the Maturity
Date, Redemption on a Redemption Date or repurchase on a Fundamental Change Repurchase Date or otherwise) of, interest on, and any cash Conversion Consideration for, any Global Note to the Depositary by wire transfer of immediately available funds
no later than the time the same is due as provided in the Indenture. 
 (B) Physical Notes. The Company will pay, or cause
the Paying Agent to pay, the principal (whether due upon maturity on the Maturity Date, Redemption on a Redemption Date or repurchase on a Fundamental Change Repurchase Date or otherwise) of, interest on, and any cash Conversion Consideration for,
any Physical Note no later than the time the same is due as provided in the Indenture as follows: (i) if the principal amount of such Physical Note is at least one million dollars ($1,000,000) (or such lower amount as the

  
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Company may choose in its sole and absolute discretion) and the Holder of such Physical Note entitled to such payment has delivered to the Paying Agent or the Trustee, no later than the time set
forth in the immediately following sentence, a written request that the Company make such payment by wire transfer to an account of such Holder within the United States, by wire transfer of immediately available funds to such account; and
(ii) in all other cases, by check mailed to the address of the Holder of such Physical Note entitled to such payment as set forth in the Register. To be timely, such written request must be so delivered no later than the Close of Business on
the following date: (x) with respect to the payment of any interest due on an Interest Payment Date, the immediately preceding Regular Record Date; (y) with respect to any cash Conversion Consideration, the relevant Conversion Date; and
(z) with respect to any other payment, the date that is fifteen (15) calendar days immediately before the date such payment is due. 

Section 2.05. Accrual of Interest; Defaulted Amounts; When Payment Date is Not a Business Day. 

(A) Accrual of Interest. Each Note will accrue interest at a rate per annum equal to 5.00% (the “Stated
Interest”), plus any Special Interest that may accrue pursuant to Section 7.03. Stated Interest on each Note will (i) accrue from, and including, the most recent date to which Stated Interest has been paid or duly provided
for (or, if no Stated Interest has theretofore been paid or duly provided for, the date set forth in the certificate representing such Note as the date from, and including, which Stated Interest will begin to accrue in such circumstance) to, but
excluding, the date of payment of such Stated Interest; and (ii) be, subject to Sections 4.02(D), 4.03(E) and 5.02(D) (but without duplication of any payment of interest), payable
semi-annually in arrears on each Interest Payment Date, beginning on the first Interest Payment Date set forth in the certificate representing such Note, to the Holder of such Note as of the Close of Business on the immediately preceding Regular
Record Date. Stated Interest, and Special Interest, on the Notes will be computed on the basis of a 360-day year comprised of twelve 30-day months. 

(B) Defaulted Amounts. If the Company fails to pay any amount (a “Defaulted Amount”) payable on a Note on
or before the due date therefor as provided in the Indenture, then, regardless of whether such failure constitutes an Event of Default, (i) such Defaulted Amount will forthwith cease to be payable to the Holder of such Note otherwise entitled
to such payment; (ii) to the extent lawful, interest (“Default Interest”) will accrue on such Defaulted Amount at a rate per annum equal to the rate per annum at which Stated Interest accrues, from, and including, such due date
to, but excluding, the date of payment of such Defaulted Amount and Default Interest; (iii) such Defaulted Amount and Default Interest will be paid on a payment date selected by the Company to the Holder of such Note as of the Close of Business
on a special record date selected by the Company, provided that such special record date must be no more than fifteen (15), nor less than ten (10), calendar days before such payment date; and (iv) at least fifteen
(15) calendar days before such special record date, the Company will send notice to the Trustee and the Holders that states such special record date, such payment date and the amount of such Defaulted Amount and Default Interest to be paid on
such payment date. 
 (C) Delay of Payment when Payment Date is Not a Business Day. If the due date for a payment on a
Note as provided in the Indenture is not a Business Day, then, notwithstanding anything to the contrary in the Indenture or the Notes, such payment may be made on the immediately following Business Day and no interest will accrue on such payment as
a result of the related delay. 
 Section 2.06. Registrar, Paying Agent and Conversion Agent. 

(A) Generally. The Company will maintain (i) an office or agency in the continental United States where Notes may be
presented for registration of transfer or for exchange (the “Registrar”); (ii) an office or agency in the continental United States where Notes may be presented for payment (the “Paying Agent”); and (iii) an
office or agency in the continental United States where Notes may be presented for conversion (the “Conversion Agent”). If the Company fails to maintain a Registrar, Paying Agent or Conversion Agent, then the Trustee will act as
such and shall receive compensation therefor in accordance with the Indenture and any other agreement between the Trustee and the Company. For the avoidance of doubt, the Company or any of its Subsidiaries may act as Registrar, Paying Agent or
Conversion Agent. 
 (B) Duties of the Registrar. The Registrar will keep a record (the “Register”) of
the names and addresses of the Holders, the Notes held by each Holder and the transfer, exchange, repurchase, Redemption and conversion of Notes. Absent manifest error, the entries in the Register will be conclusive and the Company and the Trustee
may treat each Person whose name is recorded as a Holder in the Register as a Holder for all purposes. The Register will be in written form or in any form capable of being converted into written form reasonably promptly. 

(C) Co-Agents; Company’s Right to Appoint Successor Registrars, Paying Agents and
Conversion Agents. The Company may appoint one or more co-Registrars, co-Paying Agents and co-Conversion Agents, each of whom
will be deemed to be a Registrar, Paying Agent or Conversion Agent, as applicable, under the Indenture. Subject to Section 2.06(A), the Company may change any Registrar, Paying Agent or Conversion Agent (including appointing
itself or any of its Subsidiaries to act in such capacity) without notice to any Holder. The Company will notify the Trustee (and, upon request, any Holder) of the name and address of each Note Agent, if any, not a party to the Indenture and will
enter into an appropriate agency agreement with each such Note Agent, which agreement will implement the provisions of the Indenture that relate to such Note Agent. 

  
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 (D) Initial Appointments. The Company appoints the Trustee as the initial
Paying Agent, the initial Registrar and the initial Conversion Agent. 
 Section 2.07. Paying Agent and Conversion Agent to Hold Property in Trust.

 The Company will require each Paying Agent or Conversion Agent that is not the Trustee to agree in writing that such Note Agent will
(A) hold in trust for the benefit of Holders or the Trustee all money and other property held by such Note Agent for payment or delivery due on the Notes; and (B) notify the Trustee of any default by the Company in making any such payment
or delivery. The Company, at any time, may, and the Trustee, while any Default continues, may, require a Paying Agent or Conversion Agent to pay or deliver, as applicable, all money and other property held by it to the Trustee, after which payment
or delivery, as applicable, such Note Agent (if not the Company or any of its Subsidiaries) will have no further liability for such money or property. If the Company or any of its Subsidiaries acts as Paying Agent or Conversion Agent, then
(A) it will segregate and hold in a separate trust fund for the benefit of the Holders or the Trustee all money and other property held by it as Paying Agent or Conversion Agent; and (B) references in the Indenture or the Notes to the
Paying Agent or Conversion Agent holding cash or other property, or to the delivery of cash or other property to the Paying Agent or Conversion Agent, in each case for payment or delivery to any Holders or the Trustee or with respect to the Notes,
will be deemed to refer to cash or other property so segregated and held separately, or to the segregation and separate holding of such cash or other property, respectively. Upon the occurrence of any event pursuant to clause (ix) or (x)
of Section 7.01(A) with respect to the Company (or with respect to any Subsidiary of the Company acting as Paying Agent or Conversion Agent), the Trustee will serve as the Paying Agent or Conversion Agent, as applicable, for the
Notes. 
 Section 2.08. Holder Lists. 

If the Trustee is not the Registrar, the Company will furnish to the Trustee, no later than seven (7) Business Days before each Interest
Payment Date, and at such other times as the Trustee may request, a list, in such form and as of such date or time as the Trustee may reasonably require, of the names and addresses of the Holders. 

Section 2.09. Legends. 

(A) Global Note Legend. Each Global Note will bear the Global Note Legend (or any similar legend, not inconsistent with the
Indenture, required by the Depositary for such Global Note). 
 (B) Other Legends. A Note may bear any other legend or
text, not inconsistent with the Indenture, as may be required by applicable law or by any securities exchange or automated quotation system on which such Note is traded or quoted. 

(C) Acknowledgement and Agreement by the Holders. A Holder’s acceptance of any Note bearing any legend required by
this Section 2.09 will constitute such Holder’s acknowledgement of, and agreement to comply with, the restrictions set forth in such legend. 

Section 2.10. Transfers and Exchanges; Certain Transfer Restrictions. 

(A) Provisions Applicable to All Transfers and Exchanges. 

(i) Subject to this Section 2.10, Physical Notes and beneficial interests in Global Notes may be transferred or exchanged from
time to time and the Registrar will record each such transfer or exchange in the Register. 
 (ii) Each Note issued upon transfer or
exchange of any other Note (such other Note being referred to as the “old Note” for purposes of this Section 2.10(A)(ii)) or portion thereof in accordance with the Indenture will be the valid obligation of the
Company, evidencing the same indebtedness, and entitled to the same benefits under the Indenture, as such old Note or portion thereof, as applicable. 

(iii) The Company, the Trustee and the Note Agents will not impose any service charge on any Holder for any transfer, exchange or
conversion of Notes, but the Company, the Trustee, the Registrar and the Conversion Agent may require payment of a sum sufficient to cover any transfer tax or similar governmental charge that may be imposed in connection with any transfer, exchange
or conversion of Notes, other than exchanges pursuant to Section 2.11, 2.16 or 8.05 not involving any transfer. 

  
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 (iv) Notwithstanding anything to the contrary in the Indenture or the Notes, a Note may
not be transferred or exchanged in part unless the portion to be so transferred or exchanged is in an Authorized Denomination. 

(v) The Trustee will have no obligation or duty to monitor, determine or inquire as to compliance with any transfer restrictions imposed
under the Indenture or applicable law with respect to any Security, other than to require the delivery of such certificates or other documentation or evidence as expressly required by the Indenture and to examine the same to determine substantial
compliance as to form with the requirements of the Indenture. 
 (vi) Each Note issued upon transfer of, or in exchange for, another
Note will bear each legend, if any, required by Section 2.09. 
 (vii) Upon satisfaction of the requirements of the
Indenture to effect a transfer or exchange of any Note, the Company will cause such transfer or exchange to be effected as soon as reasonably practicable but in no event later than the second (2nd) Business Day after the date of such satisfaction.

 (viii) Neither the Trustee nor any Note Agent will have any responsibility for any actions taken or not taken by the Depositary. 

(ix) The Trustee will have no obligation or duty to monitor, determine or inquire as to compliance with any transfer restrictions imposed
under the Indenture or applicable law with respect to any Security, other than to require the delivery of such certificates or other documentation or evidence as expressly required by the Indenture and to examine the same to determine substantial
compliance as to form with the requirements of the Indenture. 
 (B) Transfers and Exchanges of Global
Notes. 
 (i) Subject to the immediately following sentence, no Global Note may be transferred or exchanged in whole except
(x) by the Depositary to a nominee of the Depositary; (y) by a nominee of the Depositary to the Depositary or to another nominee of the Depositary; or (z) by the Depositary or any such nominee to a successor Depositary or a nominee of
such successor Depositary. No Global Note (or any portion thereof) may be transferred to, or exchanged for, a Physical Note; provided, however, that a Global Note will be exchanged, pursuant to customary procedures, for one
or more Physical Notes if: 
 (1) (x) the Depositary notifies the Company or the Trustee that the Depositary is unwilling or unable to
continue as depositary for such Global Note or (y) the Depositary ceases to be a “clearing agency” registered under Section 17A of the Exchange Act and, in each case, the Company fails to appoint a successor Depositary within
ninety (90) days of such notice or cessation; 
 (2) an Event of Default has occurred and is continuing and the Company, the
Trustee or the Registrar has received a written request from the Depositary, or from a holder of a beneficial interest in such Global Note, to exchange such Global Note or beneficial interest, as applicable, for one or more Physical Notes; or 

(3) the Company, in its sole discretion, permits the exchange of any beneficial interest in such Global Note for one or more Physical
Notes at the request of the owner of such beneficial interest. 
 (ii) Upon satisfaction of the requirements of the Indenture to effect
a transfer or exchange of any Global Note (or any portion thereof): 
 (1) the Trustee will reflect any resulting decrease of the
principal amount of such Global Note by notation on the “Schedule of Exchanges of Interests in the Global Note” forming part of such Global Note (and, if such notation results in such Global Note having a principal amount of zero, the
Company may (but is not required to) instruct the Trustee to cancel such Global Note pursuant to Section 2.14); 
 (2) if
required to effect such transfer or exchange, then the Trustee will reflect any resulting increase of the principal amount of any other Global Note by notation on the “Schedule of Exchanges of Interests in the Global Note” forming part of
such other Global Note; 
 (3) if required to effect such transfer or exchange, then the Company will issue, execute and deliver, and
the Trustee will authenticate, in each case in accordance with Section 2.02, a new Global Note bearing each legend, if any, required by Section 2.09; and 

  
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 (4) if such Global Note (or such portion thereof), or any beneficial interest therein,
is to be exchanged for one or more Physical Notes, then the Company will issue, execute and deliver, and the Trustee will authenticate, in each case in accordance with Section 2.02, one or more Physical Notes that (x) are in
Authorized Denominations and have an aggregate principal amount equal to the principal amount of such Global Note to be so exchanged; (y) are registered in such name(s) as the Depositary specifies (or as otherwise determined pursuant to
customary procedures); and (z) bear each legend, if any, required by Section 2.09. 
 (iii) Each transfer or exchange
of a beneficial interest in any Global Note will be made in accordance with the Depositary Procedures. 
 (C) Transfers and
Exchanges of Physical Notes. 
 (i) Subject to this Section 2.10, a Holder of a Physical Note may (x) transfer such
Physical Note (or any portion thereof in an Authorized Denomination) to one or more other Person(s); (y) exchange such Physical Note (or any portion thereof in an Authorized Denomination) for one or more other Physical Notes in Authorized
Denominations having an aggregate principal amount equal to the aggregate principal amount of the Physical Note (or portion thereof) to be so exchanged; and (z) if then permitted by the Depositary Procedures, transfer such Physical Note (or any
portion thereof in an Authorized Denomination) in exchange for a beneficial interest in one or more Global Notes; provided, however, that, to effect any such transfer or exchange, such Holder must: 

(1) surrender such Physical Note to be transferred or exchanged to the office of the Registrar, together with any endorsements or transfer
instruments reasonably required by the Company, the Trustee or the Registrar; and 
 (2) deliver such certificates, documentation or
evidence as may be required pursuant to Section 2.10(D). 
 (ii) Upon the satisfaction of the requirements of the
Indenture to effect a transfer or exchange of any Physical Note (such Physical Note being referred to as the “old Physical Note” for purposes of this Section 2.10(C)(ii)) of a Holder (or any portion of such old
Physical Note in an Authorized Denomination): 
 (1) such old Physical Note will be promptly cancelled pursuant to Section
2.15; 
 (2) if such old Physical Note is to be so transferred or exchanged only in part, then the Company will issue, execute and
deliver, and the Trustee will authenticate, in each case in accordance with Section 2.02, one or more Physical Notes that (x) are in Authorized Denominations and have an aggregate principal amount equal to the principal amount of
such old Physical Note not to be so transferred or exchanged; (y) are registered in the name of such Holder; and (z) bear each legend, if any, required by Section 2.09; 

(3) in the case of a transfer: 

(a) to the Depositary or a nominee thereof that will hold its interest in such old Physical Note (or such portion thereof) to be so
transferred in the form of one or more Global Notes, the Trustee will reflect an increase of the principal amount of one or more existing Global Notes by notation on the “Schedule of Exchanges of Interests in the Global Note” forming part
of such Global Note(s), which increase(s) are in Authorized Denominations and aggregate to the principal amount to be so transferred, and which Global Note(s) bear each legend, if any, required by Section
2.09; provided, however, that if such transfer cannot be so effected by notation on one or more existing Global Notes (whether because no Global Notes bearing each legend, if any, required by Section
2.09 then exist, because any such increase will result in any Global Note having an aggregate principal amount exceeding the maximum aggregate principal amount permitted by the Depositary or otherwise), then the Company will issue, execute
and deliver, and the Trustee will authenticate, in each case in accordance with Section 2.02, one or more Global Notes that (x) are in Authorized Denominations and have an aggregate principal amount equal to the principal amount to
be so transferred; and (y) bear each legend, if any, required by Section 2.09; and 
 (b) to a transferee that will
hold its interest in such old Physical Note (or such portion thereof) to be so transferred in the form of one or more Physical Notes, the Company will issue, execute and deliver, and the Trustee will authenticate, in each case in accordance
with Section 2.02, one or more Physical Notes that (x) are in Authorized Denominations and have an aggregate principal amount equal to the principal amount to be so transferred; (y) are registered in the name of such
transferee; and (z) bear each legend, if any, required by Section 2.09; and 
 (4) in the case of an exchange, the
Company will issue, execute and deliver, and the Trustee will authenticate, in each case in accordance with Section 2.02, one or more Physical Notes that (x) are in Authorized Denominations and have an aggregate principal amount
equal to the principal amount to be so exchanged; (y) are registered in the name of the Person to whom such old Physical Note was registered; and (z) bear each legend, if any, required by Section 2.09. 

  
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 (D) Transfers of Notes Subject to Redemption, Repurchase or Conversion.
Notwithstanding anything to the contrary in the Indenture or the Notes, the Company, the Trustee and the Registrar will not be required to register the transfer of or exchange any Note that (i) has been surrendered for conversion, except to the
extent that any portion of such Note is not subject to conversion; (ii) is subject to a Fundamental Change Repurchase Notice validly delivered, and not withdrawn, pursuant to Section 4.02(F), except to the extent that any
portion of such Note is not subject to such notice or the Company fails to pay the applicable Fundamental Change Repurchase Price when due; or (iii) has been selected for Redemption pursuant to a Redemption Notice, except to the extent that the
Company fails to pay the applicable Redemption Price when due. 
 Section 2.11. Exchange and Cancellation of Notes to Be
Converted or to Be Repurchased Pursuant to a Repurchase Upon Fundamental Change or Redemption. 
 (A) Partial Conversions of
Physical Notes and Partial Repurchases of Physical Notes Pursuant to a Repurchase Upon Fundamental Change. If only a portion of a Physical Note of a Holder is to be converted pursuant to Article 5 or repurchased pursuant to a Repurchase Upon
Fundamental Change, then, as soon as reasonably practicable after such Physical Note is surrendered for such conversion or repurchase, as applicable, the Company will cause such Physical Note to be exchanged, pursuant and subject to Section
2.10(C), for (i) one or more Physical Notes that are in Authorized Denominations and have an aggregate principal amount equal to the principal amount of such Physical Note that is not to be so converted or repurchased, as applicable,
and deliver such Physical Note(s) to such Holder; and (ii) a Physical Note having a principal amount equal to the principal amount to be so converted or repurchased, as applicable, which Physical Note will be converted or repurchased, as
applicable, pursuant to the terms of the Indenture; provided, however, that the Physical Note referred to in this clause (ii) need not be issued at any time after which such principal amount subject to such conversion or repurchase, as
applicable, is deemed to cease to be outstanding pursuant to Section 2.17. 
 (B) Cancellation of Notes that Are Converted
and Notes that Are Repurchased Pursuant to a Repurchase Upon Fundamental Change or Redemption. 
 (i) Physical Notes. If a
Physical Note (or any portion thereof that has not theretofore been exchanged pursuant to Section 2.11(A)) of a Holder is to be converted pursuant to Article 5 or repurchased pursuant to a Repurchase Upon Fundamental Change or
Redemption, then, promptly after the later of the time such Physical Note (or such portion) is deemed to cease to be outstanding pursuant to Section 2.17 and the time such Physical Note is surrendered for such conversion, repurchase
or Redemption, as applicable, (1) such Physical Note will be cancelled pursuant to Section 2.14; and (2) in the case of a partial conversion, Redemption or repurchase, as applicable, the Company will issue, execute and deliver
to such Holder, and the Trustee will authenticate, in each case in accordance with Section 2.02, one or more Physical Notes that (x) are in Authorized Denominations and have an aggregate principal amount equal to the principal
amount of such Physical Note that is not to be so converted, redeemed or repurchased, as applicable; (y) are registered in the name of such Holder; and (z) bear each legend, if any, required by Section 2.09. 

(ii) Global Notes. If a Global Note (or any portion thereof) is to be converted pursuant to Article 5 or repurchased
pursuant to a Repurchase Upon Fundamental Change or Redemption, then, promptly after the time such Note (or such portion) is deemed to cease to be outstanding pursuant to Section 2.17, the Trustee will reflect a decrease of the principal
amount of such Global Note in an amount equal to the principal amount of such Global Note to be so converted, repurchased or redeemed, as applicable, by notation on the “Schedule of Exchanges of Interests in the Global Note” forming part
of such Global Note (and, if the principal amount of such Global Note is zero following such notation, cancel such Global Note pursuant to Section 2.14). 

Section 2.12. Replacement Notes. 

If a Holder of any Note claims that such Note has been mutilated, lost, destroyed or wrongfully taken, then the Company will issue, execute and
deliver, and the Trustee will authenticate, in each case in accordance with Section 2.02, a replacement Note upon surrender to the Trustee of such mutilated Note, or upon delivery to the Trustee of evidence of such loss, destruction or
wrongful taking reasonably satisfactory to the Trustee and the Company. In the case of a lost, destroyed or wrongfully taken Note, the Company and the Trustee may require the Holder thereof to provide such security or indemnity that is reasonably
satisfactory to the Company to protect the Company and the Trustee to protect the Trustee from any loss that any of them may suffer if such Note is replaced. 

Every replacement Note issued pursuant to this Section 2.12 will be an additional obligation of the Company and will be
entitled to all of the benefits of the Indenture equally and ratably with all other Notes issued under the Indenture. 
 Section 2.13. Registered
Holders; Certain Rights with Respect to Global Notes. 
 Only the Holder of a Note will have rights under the Indenture as the owner of
such Note. Without limiting the generality of the foregoing, Depositary Participants will have no rights as such under the Indenture with respect to any Global Note held on their behalf by the Depositary or its nominee, or by the Trustee as its
custodian, and the Company, the Trustee and the Note Agents, and their respective agents, may treat the Depositary as the absolute owner of such Global Note for all purposes whatsoever; provided, however, that (A) the
Holder of any Global Note may grant proxies and otherwise authorize any Person, including Depositary Participants and Persons that hold interests in Notes through Depositary Participants, to take any action that such Holder is entitled to take with
respect to such Global Note under the Indenture or the Notes; and (B) the Company and the Trustee, and their respective agents, may give effect to any written certification, proxy or other authorization furnished by the Depositary. 

  
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 Section 2.14. Cancellation. 

Without limiting the generality of Section 3.06, the Company may at any time deliver Notes to the Trustee for cancellation. The
Registrar, the Paying Agent and the Conversion Agent will forward to the Trustee each Note duly surrendered to them for transfer, exchange, payment or conversion. The Trustee will promptly cancel all Notes so surrendered to it in accordance with its
customary procedures. Without limiting the generality of Section 2.03(B), the Company may not originally issue new Notes to replace Notes that it has paid or that have been cancelled upon transfer, exchange, payment or conversion.

 Section 2.15. Notes Held by the Company or its Affiliates. 

Without limiting the generality of Section 2.17, in determining whether the Holders of the required aggregate principal amount of
Notes have concurred in any direction, waiver or consent, Notes owned by the Company or any of its Affiliates will be deemed not to be outstanding; provided, however, that, for purposes of determining whether the Trustee is
protected in relying on any such direction, waiver or consent, only Notes that a Responsible Officer of the Trustee knows are so owned will be so disregarded. 

Section 2.16. Temporary Notes. 

Until definitive Notes are ready for delivery, the Company may issue, execute and deliver, and the Trustee will authenticate, in each case in
accordance with Section 2.02, temporary Notes. Temporary Notes will be substantially in the form of definitive Notes but may have variations that the Company considers appropriate for temporary Notes. The Company will promptly prepare,
issue, execute and deliver, and the Trustee will authenticate, in each case in accordance with Section 2.02, definitive Notes in exchange for temporary Notes. Until so exchanged, each temporary Note will in all respects be entitled to
the same benefits under the Indenture as definitive Notes. 
 Section 2.17. Outstanding Notes. 

(A) Generally. The Notes that are outstanding at any time will be deemed to be those Notes that, at such time, have been
duly executed and authenticated, excluding those Notes (or portions thereof) that have theretofore been (i) cancelled by the Trustee or delivered to the Trustee for cancellation in accordance with Section 2.14; (ii) assigned a
principal amount of zero by notation on the “Schedule of Exchanges of Interests in the Global Note” forming part of any a Global Note representing such Note; (iii) paid in full (including upon conversion) in accordance with the
Indenture; or (iv) deemed to cease to be outstanding to the extent provided in, and subject to, clause (B), (C) or (D) of this Section 2.17. 

(B) Replaced Notes. If a Note is replaced pursuant to Section 2.12, then such Note will cease to be outstanding at the
time of its replacement, unless the Trustee and the Company receive proof reasonably satisfactory to them that such Note is held by a “bona fide purchaser” under applicable law. 

(C) Maturing Notes and Notes Called for Redemption or Subject to Repurchase. If, on a Redemption Date, a Fundamental Change
Repurchase Date or the Maturity Date, the Paying Agent holds money sufficient to pay the aggregate Redemption Price, Fundamental Change Repurchase Price or principal amount, respectively, together, in each case, with the aggregate interest, in each
case due on such date, then (unless there occurs a Default in the payment of any such amount) (i) the Notes (or portions thereof) to be redeemed or repurchased, or that mature, on such date will be deemed, as of such date, to cease to be
outstanding, except to the extent provided in Sections 4.02(D), 4.03(E) or 5.02(D); and (ii) the rights of the Holders of such Notes (or such portions thereof), as such, will terminate
with respect to such Notes (or such portions thereof), other than the right to receive the Redemption Price, Fundamental Change Repurchase Price or principal amount, as applicable, of, and accrued and unpaid interest on, such Notes (or such portions
thereof), in each case as provided in the Indenture. 
 (D) Notes to Be Converted. At the Close of Business on the
Conversion Date for any Note (or any portion thereof) to be converted, such Note (or such portion) will (unless there occurs a Default in the delivery of the Conversion Consideration or interest due, pursuant to Section 5.03(B)
or Section 5.02(D), upon such conversion) be deemed to cease to be outstanding, except to the extent provided in Section 5.02(D) or Section 5.08. 

(E) Cessation of Accrual of Interest. Except as provided in Sections 4.02(D), 4.03(E)
or 5.02(D), interest will cease to accrue on each Note from, and including, the date that such Note is deemed, pursuant to this Section 2.17, to cease to be outstanding, unless there occurs a default in the payment or
delivery of any cash or other property due on such Note. 

  
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 Section 2.18. Repurchases by the Company. 

Without limiting the generality of Sections 2.14 and 3.06, the Company may, from time to time, repurchase Notes in
open market purchases or in negotiated transactions without delivering prior notice to Holders. 
 Section 2.19. CUSIP and ISIN Numbers.

 The Company may use one or more CUSIP or ISIN numbers to identify any of the Notes, and, if so, the Company and the Trustee will use
such CUSIP or ISIN number(s) in notices to Holders; provided, however, that (i) the Trustee makes no representation as to the correctness or accuracy of any such CUSIP or ISIN number; and (ii) the effectiveness of
any such notice will not be affected by any defect in, or omission of, any such CUSIP or ISIN number. The Company will promptly notify the Trustee of any change in the CUSIP or ISIN number(s) identifying any Notes. 

Article 3. COVENANTS 

Section 3.01. Payment on Notes. 

(A) Generally. The Company will pay or cause to be paid all the principal of, the Fundamental Change Repurchase Price and
Redemption Price for, interest on, and other amounts due with respect to, the Notes on the dates and in the manner set forth in the Indenture. 

(B) Deposit of Funds. Before 10:00 A.M., New York City time, on each Redemption Date, Fundamental Change Repurchase Date or
Interest Payment Date, and on the Maturity Date or any other date on which any cash amount is due on the Notes, the Company will deposit, or will cause there to be deposited, with the Paying Agent cash, in funds immediately available on such date,
sufficient to pay the cash amount due on the applicable Notes on such date. The Paying Agent will return to the Company, as soon as practicable, any money not required for such purpose. 

Section 3.02. Exchange Act Reports. 

(A) Generally. The Company will send to the Trustee copies of all reports that the Company is required to file with or
furnish to the SEC pursuant to Section 13(a) or 15(d) of the Exchange Act within fifteen (15) calendar days after the date that the Company is required to file or furnish the same (after giving effect to all applicable grace periods under
the Exchange Act); provided, however, that the Company need not send to the Trustee any material for which the Company has received, or is seeking in good faith and has not been denied, confidential treatment by the SEC. Any
report that the Company files with or furnishes to the SEC through the EDGAR system (or any successor thereto) will be deemed to be sent to the Trustee and holders at the time such report is so filed or furnished via the EDGAR system (or such
successor). It being understood that the Trustee shall have no obligation to determine whether such filings have been made. Upon the request of any Holder, the Company will provide to such Holder a copy of any report that the Company has sent the
Trustee pursuant to this Section 3.02(A), other than a report that is deemed to be sent to the Trustee pursuant to the preceding sentence. The Company will also comply with its other obligations under Section 314(a)(1) of the Trust
Indenture Act. 
 (B) Trustee’s Disclaimer. The Trustee need not determine whether the Company has filed or furnished any
material via the EDGAR system (or such successor). Delivery of reports, information and documents to the Trustee under the indenture is for informational purposes only and the information and the Trustee’s receipt of the foregoing shall
not constitute actual or constructive notice of any information contained therein, or determinable from information contained therein our compliance with any of its covenants thereunder (as to which the Trustee is entitled to rely exclusively on an
Officer’s Certificate). 
 Section 3.03 Compliance and Default Certificates. 

(A) Annual Compliance Certificate. Within a hundred twenty (120) days after December 31, 2020 and each fiscal year of the Company ending
thereafter, the Company will deliver an Officer’s Certificate to the Trustee stating (i) that the signatory thereto has supervised a review of the activities of the Company and its Subsidiaries during such fiscal year with a view towards
determining whether any Default or Event of Default has occurred; and (ii) whether, to such signatory’s knowledge, a Default or Event of Default has occurred or is continuing (and, if so, describing all such Defaults or Events of Default
and what action the Company is taking or proposes to take with respect thereto). 

  
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 (B) Default Certificate. If a Default or Event of Default occurs, then the Company will, within
thirty (30) days, deliver an Officer’s Certificate to the Trustee describing the same and what action the Company is taking or proposes to take with respect thereto. 

Section 3.04. Stay, Extension and Usury Laws. 

To the extent that it may lawfully do so, the Company (A) agrees that it will not at any time insist upon, plead, or in any manner
whatsoever claim or take the benefit or advantage of, any stay, extension or usury law (wherever or whenever enacted or in force) that may affect the covenants or the performance of the Indenture; and (B) expressly waives all benefits or
advantages of any such law and agrees that it will not, by resort to any such law, hinder, delay or impede the execution of any power granted to the Trustee by the Indenture, but will suffer and permit the execution of every such power as though no
such law has been enacted. 
 Section 3.05. Corporate Existence. 

Subject to Article 6, the Company will cause to preserve and keep in full force and effect: 

(A) its corporate existence in accordance with the organizational documents of the Company; and 

(B) the material rights (charter and statutory), licenses and franchises of the Company and its Subsidiaries; 

provided, however, that the Company need not preserve or keep in full force and effect any such license or franchise if (x) the
preservation thereof is no longer desirable in the conduct of the business of the Company and its Subsidiaries, taken as a whole; and (y) the loss thereof is not, individually or in the aggregate, materially adverse to the Holders. 

Section 3.06. Acquisition of Notes by the Company and its Affiliates. 

The Company will promptly deliver to the Trustee for cancellation all Notes that the Company or any of its Subsidiaries have purchased or
otherwise acquired. 
 Section 3.07 Further Instruments and Acts. 

At the Trustee’s request, the Company will execute and deliver such further instruments and do such further acts as may be reasonably
necessary or proper to more effectively carry out the purposes of the Indenture. 
 Article 4. REPURCHASE AND REDEMPTION 

Section 4.01 No Sinking Fund. 

No sinking fund is required to be provided for the Notes. 

Section 4.02. Right of Holders to Require the Company to Repurchase Notes upon a Fundamental Change. 

(A) Right of Holders to Require the Company to Repurchase Notes Upon a Fundamental Change. Subject to the other terms of
this Section 4.02, if a Fundamental Change occurs, then each Holder will have the right (the “Fundamental Change Repurchase Right”) to require the Company to repurchase such Holder’s Notes (or any portion thereof in
an Authorized Denomination) on the Fundamental Change Repurchase Date for such Fundamental Change for a cash purchase price equal to the Fundamental Change Repurchase Price. 

(B) Repurchase Prohibited in Certain Circumstances. If the principal amount of the Notes has been accelerated and such
acceleration has not been rescinded on or before the Fundamental Change Repurchase Date for a Repurchase Upon Fundamental Change (except in the case of an acceleration resulting from a Default by the Company in payment of the related Fundamental
Change Repurchase Price, and any related interest pursuant to the proviso to Section 4.02(D), on such Fundamental Change Repurchase Date), then (i) the Company may not repurchase any Notes pursuant to this Section
4.02; and (ii) the Company will cause any Notes theretofore surrendered for such Repurchase Upon Fundamental Change to be returned to the Holders thereof (or, if applicable with respect to Global Notes, cancel any instructions for
book-entry transfer to the Company, the Trustee or the Paying Agent of the applicable beneficial interest in such Notes in accordance with the Depositary Procedures). 

  
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 (C) Fundamental Change Repurchase Date. The Fundamental Change Repurchase
Date for any Fundamental Change will be a Business Day of the Company’s choosing that is no more than thirty five (35), nor less than twenty (20), Business Days after the date the Company sends the related Fundamental Change Notice pursuant
to Section 4.02(E). 
 (D) Fundamental Change Repurchase Price. The Fundamental Change Repurchase Price
for any Note to be repurchased upon a Repurchase Upon Fundamental Change following a Fundamental Change is an amount in cash equal to the principal amount of such Note plus accrued and unpaid interest on such Note to, but excluding, the Fundamental
Change Repurchase Date for such Fundamental Change; provided, however, that if such Fundamental Change Repurchase Date is after a Regular Record Date and on or before the next Interest Payment Date, then (i) the Holder
of such Note at the Close of Business on such Regular Record Date will be entitled, notwithstanding such Repurchase Upon Fundamental Change, to receive, on or, at the Company’s election, before such Interest Payment Date, the unpaid interest
that would have accrued on such Note to, but excluding, such Interest Payment Date (assuming, solely for these purposes, that such Note remained outstanding through such Interest Payment Date, if such Fundamental Change Repurchase Date is before
such Interest Payment Date); and (ii) the Fundamental Change Repurchase Price will not include accrued and unpaid interest on such Note to, but excluding, such Fundamental Change Repurchase Date. For the avoidance of doubt, if an Interest
Payment Date is not a Business Day within the meaning of Section 2.05(C) and such Fundamental Change Repurchase Date occurs on the Business Day immediately after such Interest Payment Date, then (x) accrued and unpaid
interest on Notes to, but excluding, such Interest Payment Date will be paid, in accordance with Section 2.05(C), on the next Business Day to Holders as of the Close of Business on the immediately preceding Regular Record Date;
and (y) the Fundamental Change Repurchase Price will include interest on Notes to be repurchased from, and including, such Interest Payment Date. 

(E) Fundamental Change Notice. On or before the twentieth (20th) calendar day after the effective date of a
Fundamental Change, the Company will send to each Holder, the Trustee, the Conversion Agent and the Paying Agent a notice of such Fundamental Change (a “Fundamental Change Notice”). 

Such Fundamental Change Notice must state: 

(i) briefly, the events causing such Fundamental Change; 

(ii) the effective date of such Fundamental Change; 

(iii) the procedures that a Holder must follow and the Depositary Procedures that Depositary Participants and Persons holding an interest
in Notes through Depositary Participants must comply to require the Company to repurchase its Notes pursuant to this Section 4.02, including the deadline for exercising the Fundamental Change Repurchase Right and the procedures for
submitting and withdrawing a Fundamental Change Repurchase Notice; 
 (iv) the Fundamental Change Repurchase Date for such Fundamental
Change; 
 (v) the Fundamental Change Repurchase Price per $1,000 principal amount of Notes for such Fundamental Change (and, if such
Fundamental Change Repurchase Date is after a Regular Record Date and on or before the next Interest Payment Date, the amount, manner and timing of the interest payment payable pursuant to the proviso to Section 4.02(D)); 

(vi) the name and address of the Paying Agent and the Conversion Agent; 

(vii) the Conversion Rate in effect on the date of such Fundamental Change Notice and a description and quantification of any adjustments
to the Conversion Rate that may result from such Fundamental Change (including pursuant to Section 5.07); 
 (viii) that
Notes for which a Fundamental Change Repurchase Notice has been duly tendered and not duly withdrawn must be delivered to the Paying Agent for the Holder thereof to be entitled to receive the Fundamental Change Repurchase Price; 

(ix) that Notes (or any portion thereof) that are subject to a Fundamental Change Repurchase Notice that has been duly tendered may be
converted only if such Fundamental Change Repurchase Notice is withdrawn in accordance with the Indenture; and 
 (x) the CUSIP and ISIN
numbers, if any, of the Notes. 
 Neither the failure to deliver a Fundamental Change Notice nor any defect in a Fundamental Change Notice
will limit the Fundamental Change Repurchase Right of any Holder or otherwise affect the validity of any proceedings relating to any Repurchase Upon Fundamental Change. 

  
 19 

 (F) Procedures to Exercise the Fundamental Change Repurchase Right. 

(i) Delivery of Fundamental Change Repurchase Notice and Notes to Be Repurchased. To exercise its Fundamental Change
Repurchase Right for a Note following a Fundamental Change, the Holder thereof must deliver to the Paying Agent: 
 (1) before the Close
of Business on the Business Day immediately before the related Fundamental Change Repurchase Date (or such later time as may be required by law), a duly completed, written Fundamental Change Repurchase Notice with respect to such Note; and 

(2) such Note, duly endorsed for transfer (if such Note is a Physical Note) or by book-entry transfer (if such Note is a Global Note).

 The Paying Agent will promptly deliver to the Company a copy of each Fundamental Change Repurchase Notice that it receives. 

(ii) Contents of Fundamental Change Repurchase Notices. Each Fundamental Change Repurchase Notice with respect to a
Note must state: 
 (1) if such Note is a Physical Note, the certificate number of such Note; 

(2) the principal amount of such Note to be repurchased, which must be an Authorized Denomination; and 

(3) that such Holder is exercising its Fundamental Change Repurchase Right with respect to such principal amount of such Note; 

provided, however, that if such Note is a Global Note, then such Fundamental Change Repurchase Notice must comply with the Depositary
Procedures (and any such Fundamental Change Repurchase Notice delivered in compliance with the Depositary Procedures will be deemed to satisfy the requirements of this Section 4.02(F)). 

(iii) Withdrawal of Fundamental Change Repurchase Notice. A Holder that has delivered a Fundamental Change Repurchase
Notice with respect to a Note may withdraw such Fundamental Change Repurchase Notice by delivering a written notice of withdrawal to the Paying Agent at any time before the Close of Business on the Business Day immediately before the related
Fundamental Change Repurchase Date. Such withdrawal notice must state: 
 (1) if such Note is a Physical Note, the certificate number of
such Note; 
 (2) the principal amount of such Note to be withdrawn, which must be an Authorized Denomination; and 

(3) the principal amount of such Note, if any, that remains subject to such Fundamental Change Repurchase Notice, which must be an
Authorized Denomination; 
 provided, however, that if such Note is a Global Note, then such withdrawal notice must comply with the
Depositary Procedures (and any such withdrawal notice delivered in compliance with the Depositary Procedures will be deemed to satisfy the requirements of this Section 4.02(F)). 

Upon receipt of any such withdrawal notice with respect to a Note (or any portion thereof), the Paying Agent will (x) promptly deliver a
copy of such withdrawal notice to the Company; and (y) if such Note is surrendered to the Paying Agent, cause such Note (or such portion thereof in accordance with Section 2.11, treating such Note as having been then surrendered for
partial repurchase in the amount set forth in such withdrawal notice as remaining subject to repurchase) to be returned to the Holder thereof (or, if applicable with respect to any Global Note, cancel any instructions for book-entry transfer to the
Company, the Trustee or the Paying Agent of the applicable beneficial interest in such Note in accordance with the Depositary Procedures). 

(G) Payment of the Fundamental Change Repurchase Price. Without limiting the Company’s obligation to deposit the
Fundamental Change Repurchase Price within the time proscribed by Section 3.01(B), the Company will cause the Fundamental Change Repurchase Price for a Note (or portion thereof) to be repurchased pursuant to a Repurchase Upon
Fundamental Change to be paid to the Holder thereof on or before the later of (i) the applicable Fundamental Change Repurchase Date; and (ii) the date (x) such Note is delivered to the Paying Agent (in the case of a Physical Note) or
(y) the Depositary Procedures relating to the repurchase, and the delivery to the Paying Agent, of such Holder’s beneficial interest in such Note to be repurchased are complied with (in the case of a

  
 20 

 
Global Note). For the avoidance of doubt, interest payable pursuant to the proviso to Section 4.02(D) on any Note to be repurchased pursuant to a Repurchase Upon Fundamental
Change must be paid pursuant to such proviso regardless of whether such Note is delivered or such Depositary Procedures are complied with pursuant to the first sentence of this Section 4.02(G). 

(H) Compliance with Applicable Securities Laws. To the extent applicable, the Company will comply in all material respects
with all federal and state securities laws in connection with a Repurchase Upon Fundamental Change (including complying with Rules 13e-4 and Regulations 14D and 14E under the Exchange Act and filing any
required Schedule TO, to the extent applicable) so as to permit effecting such Repurchase Upon Fundamental Change in the manner set forth in the Indenture; provided, however, that, to the extent that the Company’s
obligations pursuant to this Section 4.02 conflict with any law or regulation that is applicable to the Company and enacted after the Issue Date, the Company’s compliance with such law or regulation will not be considered to be
a Default of such obligations. 
 (I) Repurchase in Part. Subject to the terms of this Section 4.02, Notes may
be repurchased pursuant to a Repurchase Upon Fundamental Change in part, but only in Authorized Denominations. Provisions of this Section 4.02 applying to the repurchase of a Note in whole will equally apply to the repurchase of a
permitted portion of a Note. 
 (J) Repurchase by Third Party. Notwithstanding anything to the contrary in this Section
4.02, the Company will be deemed to satisfy its obligations to repurchase Notes pursuant to this Section 4.02 if (i) one or more third parties conduct the repurchase offer and repurchase tendered Notes in a manner that
would have satisfied the Company’s obligations to do the same if conducted directly by the Company; and (ii) an owner of a beneficial interest in the Notes would not receive a lesser amount (as a result of taxes, additional expenses or for
any other reason) than such owner would have received had the Company repurchased the Notes. 
 (K) Exempted Fundamental
Changes. 
 (i) Notwithstanding anything to the contrary, the Company will not be required to send a Fundamental Change Notice, or
offer to repurchase any Notes as set forth in this Section 4.02, in connection with a Fundamental Change occurring pursuant to clause (B)(ii) (or pursuant to clause (A) that also constitutes a Fundamental Change occurring pursuant
to (B)(ii)) of the definition of Fundamental Change, if: 
 (1) such Fundamental Change constitutes a Common Stock Change Event for
which all of the Reference Property consists of cash in U.S. dollars; 
 (2) immediately after such Fundamental Change, the Notes become
convertible (pursuant to Section 5.08 and, if applicable, Section 5.07) into consideration that consists solely of U.S. dollars in an amount per $1,000 principal amount of Notes that equals or exceeds the Fundamental
Change Repurchase Price per $1,000 principal amount of Notes (calculated assuming that the same includes accrued interest to, but excluding, the latest possible Fundamental Change Repurchase Date for such Fundamental Change) (any such Fundamental
Change described in this Section 4.02(K), an “Exempted Fundamental Change”); and 
 (3) The Company timely sends
notice of the Make-Whole Fundamental Change related to such Fundamental Change that is required pursuant to Section 5.07(c) herein. 

Section 4.03. Right of the Company to Redeem the Notes. 

(A) No Right to Redeem Before July 20, 2023. The Company may not redeem the Notes at its option at any time
before July 20, 2023. 
 (B) Right to Redeem the Notes on or After July 20, 2023. Subject to the
terms of this Section 4.03, the Company has the right, at its election, to redeem all, but not less than all, of the Notes, at any time, on a Redemption Date occurring on or after July 20, 2023, for a cash purchase price equal to
the Redemption Price, but only if the Last Reported Sale Price per share of Common Stock exceeds one hundred and thirty percent (130%) of the Conversion Price on (i) each of at least twenty (20) Trading Days (whether or not consecutive)
during the thirty (30) consecutive Trading Days ending on, and including, the Trading Day immediately before the Redemption Notice Date for such Redemption; and (ii) the Trading Day immediately before such Redemption Notice Date. For the
avoidance of doubt, the calling of any Notes for Redemption will constitute a Make-Whole Fundamental Change pursuant to clause (B) of the definition thereof. 

(C) Redemption Prohibited in Certain Circumstances. If the principal amount of the Notes has been accelerated and such
acceleration has not been rescinded on or before the Redemption Date (except in the case of an acceleration resulting from a Default by the Company in the payment of the related Redemption Price, and any related interest pursuant to the proviso
to Section 4.03(E), on 

  
 21 

 
such Redemption Date), then (i) the Company may not call for Redemption or otherwise redeem any Notes pursuant to this Section 4.03; and (ii) the Company will cause any
Notes theretofore surrendered for such Redemption to be returned to the Holders thereof (or, if applicable with respect to Global Notes, cancel any instructions for book-entry transfer to the Company, the Trustee or the Paying Agent of the
applicable beneficial interests in such Notes in accordance with the Depositary Procedures). 
 (D) Redemption Date. The
Redemption Date for any Redemption will be a Business Day of the Company’s choosing that is no more than sixty (60), nor less than thirty (30), calendar days after the Redemption Notice Date for such Redemption. 

(E) Redemption Price. The Redemption Price for any Note called for Redemption is an amount in cash equal to the principal amount of
such Note plus accrued and unpaid interest on such Note to, but excluding, the Redemption Date for such Redemption; provided, however, that if such Redemption Date is after a Regular Record Date and on or before the next
Interest Payment Date, then (i) the Holder of such Note at the Close of Business on such Regular Record Date will be entitled, notwithstanding such Redemption, to receive, on or, at the Company’s election, before such Interest Payment
Date, the unpaid interest that would have accrued on such Note to, but excluding, such Interest Payment Date (assuming, solely for these purposes, that such Note remained outstanding through such Interest Payment Date, if such Redemption Date is
before such Interest Payment Date); and (ii) the Redemption Price will not include accrued and unpaid interest on such Note to, but excluding, such Redemption Date. For the avoidance of doubt, if an Interest Payment Date is not a Business Day
within the meaning of Section 2.05(C) and such Redemption Date occurs on the Business Day immediately after such Interest Payment Date, then (x) accrued and unpaid interest on Notes to, but excluding, such Interest Payment
Date will be paid, in accordance with Section 2.05(C), on the next Business Day to Holders as of the Close of Business on the immediately preceding Regular Record Date; and (y) the Redemption Price will include interest on
Notes to be redeemed from, and including, such Interest Payment Date. 
 (F) Redemption Notice. To call any Notes for
Redemption, the Company must send to each Holder of such Notes, the Trustee, the Paying Agent and the Conversion Agent (if other than the Trustee) a written notice of such Redemption (a “Redemption Notice”) . 

Such Redemption Notice must state: 

(i) that such Notes have been called for Redemption, briefly describing the Company’s Redemption right under the Indenture; 

(ii) the Redemption Date for such Redemption; 

(iii) the Redemption Price per $1,000 principal amount of Notes for such Redemption (and, if the Redemption Date is after a Regular Record
Date and on or before the next Interest Payment Date, the amount, manner and timing of the interest payment payable pursuant to the proviso to Section 4.03(E)); 

(iv) the name and address of the Paying Agent and the Conversion Agent; 

(v) that Notes called for Redemption may be converted at any time before the Close of Business on the Business Day immediately before the
Redemption Date (or, if the Company fails to pay the Redemption Price due on such Redemption Date in full, at any time until such time as the Company pays such Redemption Price in full); 

(vi) the Conversion Rate in effect on the Redemption Notice Date for such Redemption and a description and quantification of any
adjustments to the Conversion Rate that may result from such Redemption (including pursuant to Section 5.07); and 
 (vii) the CUSIP and
ISIN numbers, if any, of the Notes. 
 On or before the Redemption Notice Date, the Company will send a copy of such Redemption Notice to
the Trustee and the Paying Agent. At the Company’s request, the Trustee will give the Redemption Notice to each Holders (but not any beneficial owner of a Global Note) in the Company’s name and at its
expense, provided that the Company delivers to the Trustee, at least five (5) calendar days prior to the Redemption Notice Date (unless the Trustee agrees to a shorter period), an Officer’s Certificate requesting that the
Trustee give such notice and setting forth the information to be stated in such notice as provided in this Section 4.03(F). 

(G) Payment of the Redemption Price. Without limiting the Company’s obligation to deposit the Redemption Price by the
time proscribed by Section 3.01(B), the Company will cause the Redemption Price for a Note subject to Redemption to be paid to the Holder thereof on or before the applicable Redemption Date. For the avoidance of doubt, interest
payable pursuant to the proviso to Section 4.03(E) on any Note (or portion thereof) subject to Redemption must be paid pursuant to such proviso. 

  
 22 

 Article 5. CONVERSION 

Section 5.01. Right to Convert. 

(A) Generally. Subject to the provisions of this Article 5, each Holder may, at its option, convert such Holder’s
Notes into Conversion Consideration. 
 (B) Conversions in Part. Subject to the terms of the Indenture, Notes may be
converted in part, but only in Authorized Denominations. Provisions of this Article 5 applying to the conversion of a Note in whole will equally apply to conversions of a permitted portion of a Note. 

(C) When Notes May Be Converted. 

(i) Generally. A Holder may convert its Notes at any time until the Close of Business on the second Scheduled Trading Day
immediately before the Maturity Date. 
 (ii) Limitations and Closed Periods. Notwithstanding anything to the contrary in
the Indenture or the Notes: 
 (1) Notes may be surrendered for conversion only after the Open of Business and before the Close of
Business on a day that is a Business Day; 
 (2) in no event may any Note be converted after the Close of Business on the second
Scheduled Trading Day immediately before the Maturity Date; 
 (3) if the Company calls any Note for Redemption pursuant
to Section 4.03, then the Holder of such Note may not convert such Note after the Close of Business on the second Business Day immediately before the applicable Redemption Date, except to the extent the Company fails to pay the
Redemption Price for such Note in accordance with the Indenture; and 
 (4) if a Fundamental Change Repurchase Notice is validly
delivered pursuant to Section 4.02(F) with respect to any Note, then such Note may not be converted, except to the extent (a) such Note is not subject to such notice; (b) such notice is withdrawn in accordance
with Section 4.02(F); or (c) the Company fails to pay the Fundamental Change Repurchase Price for such Note in accordance with the Indenture. 

Section 5.02. Conversion Procedures. 

(A) Generally. 

(i) Global Notes. To convert a beneficial interest in a Global Note, the owner of such beneficial interest must (1) comply
with the Depositary Procedures for converting such beneficial interest (at which time such conversion will become irrevocable); and (2) pay any amounts due pursuant to Section 5.02(D) or Section 5.02(E).

 (ii) Physical Notes. To convert all or a portion of a Physical Note, the Holder of such Note must (1) complete,
manually sign and deliver to the Conversion Agent the conversion notice attached to such Physical Note or a facsimile of such conversion notice; (2) deliver such Physical Note to the Conversion Agent (at which time such conversion will become
irrevocable); (3) furnish any endorsements and transfer documents that the Company or the Conversion Agent may require; and (4) pay any amounts due pursuant to Section 5.02(D) or Section 5.02(E). 

(B) Effect of Converting a Note. At the Close of Business on the Conversion Date for a Note (or any portion thereof) to be
converted, such Note (or such portion) will (unless there occurs a Default in the delivery of the Conversion Consideration or interest due, pursuant to Section 5.03(A) or 5.02(D), upon such conversion) be deemed
to cease to be outstanding (and, for the avoidance of doubt, no Person will be deemed to be a Holder of such Note (or such portion thereof) as of the Close of Business on such Conversion Date), except to the extent provided in Section
5.02(D). 
 (C) Holder of Record of Conversion Shares. The Person in whose name any share of Common Stock is
issuable upon conversion of any Note will be deemed to become the holder of record of such share as of the Close of Business on the Conversion Date for such conversion. 

  
 23 

 (D) Interest Payable upon Conversion in Certain Circumstances. If the
Conversion Date of a Note is after a Regular Record Date and before the next Interest Payment Date, then (i) the Holder of such Note at the Close of Business on such Regular Record Date will be entitled, notwithstanding such conversion (and,
for the avoidance of doubt, notwithstanding anything set forth in the proviso to this sentence), to receive, on or, at the Company’s election, before such Interest Payment Date, the unpaid interest that would have accrued on such Note to, but
excluding, such Interest Payment Date (assuming, solely for these purposes, that such Note remained outstanding through such Interest Payment Date); and (ii) the Holder surrendering such Note for conversion must deliver to the Conversion Agent,
at the time of such surrender, an amount of cash equal to the amount of such interest referred to in clause (i) above; provided, however, that the Holder surrendering such Note for conversion need not deliver such cash
(v) if the Company has specified a Redemption Date that is after such Regular Record Date and on or before the Business Day immediately after such Interest Payment Date; (w) if such Conversion Date occurs after the Regular Record Date
immediately before the Maturity Date; (x) if the Company has specified a Fundamental Change Repurchase Date that is after such Regular Record Date and on or before the Business Day immediately after such Interest Payment Date or (y) to the
extent of any overdue interest or interest that has accrued on any overdue interest. For the avoidance of doubt, as a result of, and without limiting the generality of, the foregoing, if a Note is converted with a Conversion Date that is after the
Regular Record Date immediately before the Maturity Date, then the Company will pay, as provided above, the interest that would have accrued on such Note to, but excluding, the Maturity Date. For the avoidance of doubt, if the Conversion Date of a
Note to be converted is on an Interest Payment Date, then the Holder of such Note at the Close of Business on the Regular Record Date immediately before such Interest Payment Date will be entitled to receive, on such Interest Payment Date, the
unpaid interest that has accrued on such Note to, but excluding, such Interest Payment Date, and such Note, when surrendered for conversion, need not be accompanied by any cash amount pursuant to the first sentence of this Section
5.02(D). 
 (E) Taxes and Duties. If a Holder converts a Note, the Company will pay any documentary, stamp or similar
issue or transfer tax or duty due on the issue or delivery of any shares of Common Stock upon such conversion; provided, however, that if any tax or duty is due because such Holder requested such shares to be registered in a
name other than such Holder’s name, then such Holder will pay such tax or duty and, until having received a sum sufficient to pay such tax or duty, the Conversion Agent may refuse to deliver any such shares to be issued in a name other than
that of such Holder. 
 (F) Conversion Agent to Notify Company of Conversions. If any Note is submitted for conversion to
the Conversion Agent or the Conversion Agent receives any notice of conversion with respect to a Note, then the Conversion Agent will promptly notify the Company and the Trustee of such occurrence, together with any other information reasonably
requested by the Company, and will cooperate with the Company for the Company to determine the Conversion Date for such Note. 

Section 5.03. Settlement upon Conversion. 

(A) Conversion Consideration. 

(i) Generally. Subject to Section 5.03(A)(ii) and Section 5.03(A)(iii),
the type and amount of consideration (the “Conversion Consideration”) due in respect of each $1,000 principal amount of a Note to be converted will be a number of shares of Common Stock equal to the Conversion Rate in effect on the
Conversion Date for such conversion. 
 (ii) Cash in Lieu of Fractional Shares. If the number of shares of Common Stock
deliverable pursuant to Section 5.03(A)(i) upon conversion of any Note is not a whole number, then such number will be rounded down to the nearest whole number and the Company will deliver, in addition to the other
consideration due upon such conversion, cash in lieu of the related fractional share in an amount equal to the product of (1) such fraction and (2) the Last Reported Sale Price per share of Common Stock on the Conversion Date for such
conversion (or, if such Conversion Date is not a Trading Day, the immediately preceding Trading Day). 

(iii) Conversion of Multiple Notes by a Single Holder. If a Holder converts more than one (1) Note on a single
Conversion Date, then the Conversion Consideration due in respect of such conversion will (in the case of any Global Note, to the extent permitted by, and practicable under, the Depositary Procedures) be computed based on the total principal amount
of Notes converted on such Conversion Date by such Holder. 
 (B) Delivery of the Conversion Consideration. Except as set
forth in Section 5.05(C), the Company will pay or deliver, as applicable, the Conversion Consideration due upon the conversion of any Note to the Holder on or before the second (2nd) Business Day immediately after the Conversion
Date for such conversion. 
 (C) Deemed Payment of Principal and Interest; Settlement of Accrued Interest Notwithstanding
Conversion. If a Holder converts a Note, then the Company will not adjust the Conversion Rate to account for any accrued and unpaid interest on such Note, and, except as provided in Section 5.02(D), the Company’s delivery
of the Conversion Consideration due in respect of such conversion will be deemed to fully satisfy and discharge the Company’s obligation to pay the principal of, and accrued and unpaid interest, if any, on, such Note. As a result, except as
provided in Section 5.02(D), any accrued and unpaid interest on a converted Note will be deemed to be paid in full rather than cancelled, extinguished or forfeited. 

  
 24 

 Section 5.04. Reserve and Status of Common Stock Issued upon Conversion. 

(A) Stock Reserve. At all times when any Notes are outstanding, the Company will reserve, out of its authorized but unissued
and unreserved shares of Common Stock, a number of shares of Common Stock sufficient to permit the conversion of all then-outstanding Notes, assuming the Conversion Rate is increased by the maximum amount pursuant to which the Conversion Rate may be
increased pursuant to Section 5.07. 
 (B) Status of Conversion Shares; Listing. Each Conversion Share
delivered upon conversion of any Note will be a newly issued or treasury share and will be duly and validly issued, fully paid, non-assessable, free from preemptive rights and free of any lien or adverse claim
(except to the extent of any lien or adverse claim created by the action or inaction of the Holder of such Note or the Person to whom such Conversion Share will be delivered). If the Common Stock is then listed on any securities exchange, or quoted
on any inter-dealer quotation system, then the Company will cause each Conversion Share, when delivered upon conversion of any Note, to be admitted for listing on such exchange or quotation on such system. 

Section 5.05. Adjustments to the Conversion Rate. 

(A) Events Requiring an Adjustment to the Conversion Rate. The Conversion Rate will be adjusted from time to time as
follows: 
 (i) Stock Dividends, Splits and Combinations. If the Company issues solely shares of Common Stock as a
dividend or distribution on all or substantially all shares of the Common Stock, or if the Company effects a stock split or a stock combination of the Common Stock (in each case excluding an issuance solely pursuant to a Common Stock Change Event,
as to which Section 5.08 will apply), then the Conversion Rate will be adjusted based on the following formula: 
  

 
 where: 

CR0 = the Conversion Rate in effect immediately before the Open of Business
on the Ex-Dividend Date for such dividend or distribution, or immediately before the Open of Business on the effective date of such stock split or stock combination, as applicable; 

CR1 = the Conversion Rate in effect immediately after the Open of Business on
such Ex-Dividend Date or effective date, as applicable; 
 OS0 = the number of shares of Common Stock outstanding immediately before the Open of Business on such Ex-Dividend Date or effective date, as
applicable, without giving effect to such dividend, distribution, stock split or stock combination; and 
 OS1 = the number of shares of Common Stock outstanding immediately after giving effect to such dividend, distribution, stock split or stock combination. 

If any dividend, distribution, stock split or stock combination of the type described in this Section 5.05(A)(i) is declared or
announced, but not so paid or made, then the Conversion Rate will be readjusted, effective as of the date the Board of Directors determines not to pay such dividend or distribution or to effect such stock split or stock combination, to the
Conversion Rate that would then be in effect had such dividend, distribution, stock split or stock combination not been declared or announced. 

(ii) Rights, Options and Warrants. If the Company distributes, to all or substantially all holders of Common Stock, rights,
options or warrants (other than rights issued or otherwise distributed pursuant to a stockholder rights plan, as to which Sections 5.05(A)(iii)(1) and 5.05(E) will apply) entitling such holders,
for a period of not more than sixty (60) calendar days after the record date of such distribution, to subscribe for or purchase shares of Common Stock at a price per share that is less than the average of the Last Reported Sale Prices per share
of Common Stock for the ten (10) consecutive Trading Days ending on, and including, the Trading Day immediately before the date such distribution is announced, then the Conversion Rate will be increased based on the following formula: 

  
 25 

 

 
 where: 
 CR0 = the Conversion Rate in effect immediately before the Open of Business on the Ex-Dividend Date for such distribution; 

CR1 = the Conversion Rate in effect immediately after the Open of Business on
such Ex-Dividend Date; 
 OS = the number of shares of Common Stock outstanding immediately before
the Open of Business on such Ex-Dividend Date; 
 X = the total number of shares of Common Stock
issuable pursuant to such rights, options or warrants; and 
 Y = a number of shares of Common Stock obtained by dividing (x) the
aggregate price payable to exercise such rights, options or warrants by (y) the average of the Last Reported Sale Prices per share of Common Stock for the ten (10) consecutive Trading Days ending on, and including, the Trading Day
immediately before the date such distribution is announced. 
 To the extent such rights, options or warrants are not so distributed, the Conversion Rate
will be readjusted to the Conversion Rate that would then be in effect had the increase to the Conversion Rate for such distribution been made on the basis of only the rights, options or warrants, if any, actually distributed. In addition, to the
extent that shares of Common Stock are not delivered after the expiration of such rights, options or warrants (including as a result of such rights, options or warrants not being exercised), the Conversion Rate will be readjusted to the Conversion
Rate that would then be in effect had the increase to the Conversion Rate for such distribution been made on the basis of delivery of only the number of shares of Common Stock actually delivered upon exercise of such rights, option or warrants. 

For purposes of this Section 5.05(A)(ii), in determining whether any rights, options or warrants entitle holders of Common Stock to
subscribe for or purchase shares of Common Stock at a price per share that is less than the average of the Last Reported Sale Prices per share of Common Stock for the ten (10) consecutive Trading Days ending on, and including, the Trading Day
immediately before the date the distribution of such rights, options or warrants is announced, and in determining the aggregate price payable to exercise such rights, options or warrants, there will be taken into account any consideration the
Company receives for such rights, options or warrants and any amount payable on exercise thereof, with the value of such consideration, if not cash, to be determined by the Company in good faith. 

(iii) Spin-Offs and Other Distributed Property. 

(1) Distributions Other than Spin-Offs. If the Company distributes shares of its Capital Stock, evidences of its
indebtedness or other assets or property of the Company, or rights, options or warrants to acquire Capital Stock of the Company or other securities, to all or substantially all holders of the Common Stock, excluding: 

(u) dividends, distributions, rights, options or warrants for which an adjustment to the Conversion Rate is required (or would be required
without regard to the “deferral exception” as set forth under Section 5.05(K)) pursuant to Section 5.05(A)(i) or 5.05(A)(ii); 

(v) dividends or distributions paid exclusively in cash for which an adjustment to the Conversion Rate is required pursuant (or would be
required without regard to the “deferral exception” as set forth under Section 5.05(K)) to Section 5.05(A)(iv); 

(w) rights issued or otherwise distributed pursuant to a stockholder rights plan, except to the extent provided in Section
5.05(E); 
 (x) Spin-Offs for which an adjustment to the Conversion Rate is required (or would be required without regard to the
“deferral exception” as set forth under Section 5.05(K)) pursuant to Section 5.05(A)(iii)(2); 

(y) a distribution solely pursuant to a tender offer or exchange offer for shares of Common Stock, as to which Section
5.05(A)(v) will apply; and 
 (z) a distribution solely pursuant to a Common Stock Change Event, as to
which Section 5.08 will apply, 
 then the Conversion Rate will be increased based on the following formula: 

  
 26 

 

 
 where: 
 CR0 = the Conversion Rate in effect immediately before the Open of Business on the Ex-Dividend Date for such distribution; 

CR1 = the Conversion Rate in effect immediately after the Open of Business on
such Ex-Dividend Date; 
 SP = the average of the Last Reported Sale Prices per share of Common
Stock for the ten (10) consecutive Trading Days ending on, and including, the Trading Day immediately before such Ex-Dividend Date; and 

FMV = the fair market value (as determined by the the Company in good faith), as of such Ex-Dividend
Date, of the shares of Capital Stock, evidences of indebtedness, assets, property, rights, options or warrants distributed per share of Common Stock pursuant to such distribution; 

provided, however, that if FMV is equal to or greater than SP, then, in lieu of the foregoing adjustment to
the Conversion Rate, each Holder will receive, for each $1,000 principal amount of Notes held by such Holder on the record date for such distribution, at the same time and on the same terms as holders of Common Stock, the amount and kind of shares
of Capital Stock, evidences of indebtedness, assets, property, rights, options or warrants that such Holder would have received if such Holder had owned, on such record date, a number of shares of Common Stock equal to the Conversion Rate in effect
on such record date. To the extent such distribution is not so paid or made, the Conversion Rate will be readjusted to the Conversion Rate that would then be in effect had the adjustment been made on the basis of only the distribution, if any,
actually made or paid. 
 (2) Spin-Offs. If the Company distributes or dividends shares of Capital Stock of any class or
series, or similar equity interests, of or relating to an Affiliate, a Subsidiary or other business unit of the Company to all or substantially all holders of the Common Stock (other than solely pursuant to (x) a Common Stock Change Event, as
to which Section 5.08 will apply; or (y) a tender offer or exchange offer for shares of Common Stock, as to which Section 5.05(A)(v) will apply), and such Capital Stock or equity interests are listed
or quoted (or will be listed or quoted upon the consummation of the transaction) on a U.S. national securities exchange (a “Spin-Off”), then the Conversion Rate will be increased based on the
following formula: 
  
 

 
 where: 
 CR0 = the Conversion Rate in effect immediately before the Close of Business on the last Trading Day of the Spin-Off Valuation Period for such Spin-Off; 
 CR1 = the Conversion Rate in
effect immediately after the Close of Business on the last Trading Day of the Spin-Off Valuation Period; 

FMV = the product of (x) the average of the Last Reported Sale Prices per share or unit of the Capital Stock or equity interests
distributed in such Spin-Off over the ten (10) consecutive Trading Day period (the “Spin-Off Valuation Period”) beginning on, and including, the Ex-Dividend Date for such Spin-Off (such average to be determined as if references to Common Stock in the definitions of Last Reported Sale Price, Trading Day and Market
Disruption Event were instead references to such Capital Stock or equity interests); and (y) the number of shares or units of such Capital Stock or equity interests distributed per share of Common Stock in such
Spin-Off; and 
 SP = the average of the Last Reported Sale Prices per share of Common Stock for
each 
 Trading Day in the Spin-Off Valuation Period. 

Notwithstanding anything to the contrary in this Section 5.05(A)(iii)(2), if the Conversion Date for a Note occurs during the
Spin-Off Valuation Period for such Spin-Off, then, solely for purposes of determining the Conversion Consideration for such conversion, such Spin-Off Valuation Period will be deemed to consist of the Trading Days occurring in the period from, and including, the Ex-Dividend Date for such Spin-Off to, and including, such Conversion Date. 

  
 27 

 To the extent any dividend or distribution of the type set forth in this Section
5.05(A)(iii)(2) is declared but not made or paid, the Conversion Rate will be readjusted to the Conversion Rate that would then be in effect had the adjustment been made on the basis of only the dividend or distribution, if
any, actually made or paid. 
 (iv) Cash Dividends or Distributions. If any cash dividend or distribution is made to all
or substantially all holders of Common Stock, then the Conversion Rate will be increased based on the following formula: 
  

 
 where: 

CR0 = the Conversion Rate in effect immediately before the Open of Business
on the Ex-Dividend Date for such dividend or distribution; 
 CR1 = the Conversion Rate in effect immediately after the Open of Business on such Ex-Dividend Date; 

SP = the Last Reported Sale Price per share of Common Stock on the Trading Day immediately before such
Ex-Dividend Date; and 
 D = the cash amount distributed per share of Common Stock in such
dividend or distribution; 
 provided, however, that if D is equal to or greater than SP, in lieu of the
foregoing adjustment to the Conversion Rate, each Holder will receive, for each $1,000 principal amount of Notes held by such Holder on the record date for such dividend or distribution, at the same time and on the same terms as holders of Common
Stock, the amount of cash that such Holder would have received if such Holder had owned, on such record date, a number of shares of Common Stock equal to the Conversion Rate in effect on such record date, then no adjustment to the Conversion Rate
will be made. 
 To the extent such dividend or distribution is declared but not made or paid, the Conversion Rate will be readjusted to the Conversion Rate
that would then be in effect had the adjustment been made on the basis of only the dividend or distribution, if any, actually made or paid. 

(v) Tender Offers or Exchange Offers. If the Company or any of its Subsidiaries makes a payment in respect of a tender offer
or exchange offer for shares of Common Stock that is subject to the then-applicable tender offer rules under the Exchange Act (other than an odd-lot tender offer that satisfies the requirements of Rule 13e-4(h)(5), or any successor rule), and the value (determined as of the Expiration Time by the Company in good faith) of the cash and other consideration paid per share of Common Stock in such tender or exchange
offer exceeds the Last Reported Sale Price per share of Common Stock on the Trading Day immediately after the last date (the “Expiration Date”) on which tenders or exchanges may be made pursuant to such tender or exchange offer (as
it may be amended), then the Conversion Rate will be increased based on the following formula: 
  
 

 
 where: 
 CR0 = the Conversion Rate in effect immediately before Close of Business on the last Trading Day of the Tender/Exchange Offer Valuation Period for such tender or exchange offer; 

CR1 = the Conversion Rate in effect immediately after the Close of Business
on the last Trading Day of the Tender/Exchange Offer Valuation Period; 
 AC = the aggregate value (determined as of the time (the
“Expiration Time”) such tender or exchange offer expires by the Company in good faith) of all cash and other consideration paid for shares of Common Stock purchased or exchanged in such tender or exchange offer; 

  
 28 

 OS0 = the number of shares
of Common Stock outstanding immediately before the Expiration Time (including all shares of Common Stock accepted for purchase or exchange in such tender or exchange offer); 

OS1 = the number of shares of Common Stock outstanding immediately after the
Expiration Time (excluding all shares of Common Stock accepted for purchase or exchange in such tender or exchange offer); and 
 SP = the
average of the Last Reported Sale Prices per share of Common Stock over the ten (10) consecutive Trading Day period (the “Tender/Exchange Offer Valuation Period”) beginning on, and including, the Trading Day immediately after
the Expiration Date; 
 provided, however, that the Conversion Rate will in no event be adjusted down pursuant to this Section
5.05(A)(v), except to the extent provided in the immediately following paragraph. Notwithstanding anything to the contrary in this Section 5.05(A)(v), if the Conversion Date for a Note occurs during the
Tender/Exchange Offer Valuation Period for such tender or exchange offer, then, solely for purposes of determining the Conversion Consideration for such conversion, such Tender/Exchange Offer Valuation Period will be deemed to consist of the Trading
Days occurring in the period from, and including, the Trading Day immediately after the Expiration Date to, and including, such Conversion Date. 
 To the
extent such tender or exchange offer is announced but not consummated (including as a result of the Company being precluded from consummating such tender or exchange offer under applicable law), or any purchases or exchanges of shares of Common
Stock in such tender or exchange offer are rescinded, the Conversion Rate will be readjusted to the Conversion Rate that would then be in effect had the adjustment been made on the basis of only the purchases or exchanges of shares of Common Stock,
if any, actually made, and not rescinded, in such tender or exchange offer. 
 (B) No Adjustments in Certain Cases. 

(i) Where Holders Participate in the Transaction or Event Without Conversion. Notwithstanding anything to the contrary
in Section 5.05(A), the Company will not be obligated to adjust the Conversion Rate on account of a transaction or other event otherwise requiring an adjustment pursuant to Section 5.05(A) (other than a stock
split or combination of the type set forth in Section 5.05(A)(i) or a tender or exchange offer of the type set forth in Section 5.05(A)(v)) if each Holder participates, at the same time and on the
same terms as holders of Common Stock, and solely by virtue of being a Holder of Notes, in such transaction or event without having to convert such Holder’s Notes and as if such Holder held a number of shares of Common Stock equal to the
product of (i) the Conversion Rate in effect on the related record date; and (ii) the aggregate principal amount (expressed in thousands) of Notes held by such Holder on such date. 

(ii) Certain Events. The Company will not be required to adjust the Conversion Rate except as provided in Section
5.05 or Section 5.07. Without limiting the foregoing, the Company will not be obligated to adjust the Conversion Rate on account of: 

(1) except as otherwise provided in Section 5.05, the sale of shares of Common Stock for a purchase price that is less than
the market price per share of Common Stock or less than the Conversion Price; 
 (2) the issuance of any shares of Common Stock pursuant
to any present or future plan providing for the reinvestment of dividends or interest payable on the Company’s securities and the investment of additional optional amounts in shares of Common Stock under any such plan; 

(3) the issuance of any shares of Common Stock or options or rights to purchase shares of Common Stock pursuant to any present or future
employee, director or consultant benefit or incentive plan or program of, or assumed by, the Company or any of its Subsidiaries; 

(4) the issuance of any shares of Common Stock pursuant to any option, warrant, right or convertible or exchangeable security of the
Company outstanding as of the Issue Date; 
 (5) a third-party tender offer, other than a tender offer that is subject to
Section 5.05(A)(5); 
 (6) the repurchase of any of shares of the Company’s Common Stock pursuant to an open market share
purchase program or other buyback transaction, including structured or derivative transactions such as accelerated share repurchase transactions or similar forward derivatives, or other buyback transaction, in each case that is not subject to
Section 5.05(A)(5); 
 (7) solely a change in the par value of the Common Stock; or 

  
 29 

 (8) accrued and unpaid interest on the Notes. 

(c) Adjustments Not Yet Effective. Notwithstanding anything to the contrary in the Indenture or the Notes, if: 

(i) a Note is to be converted; 

(ii) the record date, effective date or Expiration Time for any event that requires an adjustment to the Conversion Rate pursuant
to Section 5.05(A) has occurred on or before the Conversion Date for such conversion, but an adjustment to the Conversion Rate for such event has not yet become effective as of such Conversion Date; 

(iii) the Conversion Consideration due upon such conversion includes any whole shares of Common Stock; and 

(iv) such shares are not entitled to participate in such event (because they were not held on the related record date or otherwise), 

then, solely for purposes of such conversion, the Company will, without duplication, give effect to such adjustment on such Conversion Date. In such case, if
the date on which the Company is otherwise required to deliver the consideration due upon such conversion is before the first date on which the amount of such adjustment can be determined, then the Company will delay the settlement of such
conversion until the second (2nd) Business Day after such first date. 
 (D) Conversion Rate Adjustments where Converting
Holders Participate in the Relevant Transaction or Event. Notwithstanding anything to the contrary in the Indenture or the Notes, if: 

(i) a Conversion Rate adjustment for any dividend or distribution becomes effective on any
Ex-Dividend Date pursuant to Section 5.05(A); 
 (ii) a Note is to be
converted; 
 (iii) the Conversion Date for such conversion occurs on or after such Ex-Dividend
Date and on or before the related record date; 
 (iv) the Conversion Consideration due upon such conversion includes any whole shares
of Common Stock based on a Conversion Rate that is adjusted for such dividend or distribution; and 
 (v) such shares would be entitled
to participate in such dividend or distribution, 
 then (x) such Conversion Rate adjustment will not be given effect for such conversion; (y) the
shares of Common Stock issuable upon such conversion based on such unadjusted Conversion Rate will not be entitled to participate in such dividend or distribution; and (z) there will be added, to the Conversion Consideration otherwise due upon
such conversion, the same kind and amount of consideration that would have been delivered in such dividend or distribution with respect to such shares of Common Stock had such shares been entitled to participate in such dividend or distribution.

 (E) Stockholder Rights Plans. If any shares of Common Stock are to be issued upon conversion of any Note and, at the
time of such conversion, the Company has in effect any stockholder rights plan, then the Holder of such Note will be entitled to receive, in addition to, and concurrently with the delivery of, the Conversion Consideration otherwise payable under the
Indenture upon such conversion, the rights set forth in such stockholder rights plan, unless such rights have separated from the Common Stock at such time, in which case, and only in such case, the Conversion Rate will be adjusted pursuant
to Section 5.05(A)(iii)(1) on account of such separation as if, at the time of such separation, the Company had made a distribution of the type referred to in such Section to all holders of the Common Stock, subject
to readjustment in accordance with such Section if such rights expire, terminate or are redeemed. 
 (F) Limitation on
Effecting Transactions Resulting in Certain Adjustments. The Company will not engage in or be a party to any transaction or event that would require the Conversion Rate to be adjusted pursuant to Section 5.05(A)
or Section 5.07 to an amount that would result in the Conversion Price per share of Common Stock being less than the par value per share of Common Stock. 

  
 30 

 (G) Equitable Adjustments to Prices. Whenever any provision of the
Indenture requires the Company to calculate the average of the Last Reported Sale Prices, or any function thereof, over a period of multiple days (including to calculate the Stock Price or an adjustment to the Conversion Rate), the Company will make
proportionate adjustments, if any, to such calculations to account for any adjustment to the Conversion Rate pursuant to Section 5.05(A)(i) that becomes effective, or any event requiring such an adjustment to the Conversion
Rate where the Ex-Dividend Date or effective date, as applicable, of such event occurs, at any time during such period. 

(H) Calculation of Number of Outstanding Shares of Common Stock. For purposes of Section 5.05(A), the
number of shares of Common Stock outstanding at any time will (i) include shares issuable in respect of scrip certificates issued in lieu of fractions of shares of Common Stock; and (ii) exclude shares of Common Stock held in the
Company’s treasury (unless the Company pays any dividend or makes any distribution on shares of Common Stock held in its treasury). 

(I) Calculations. All calculations with respect to the Conversion Rate and adjustments thereto will be made to the nearest
1/10,000th of a share of Common Stock (with 5/100,000ths rounded upward). 
 (J) Notice of Conversion Rate Adjustments.
Upon the effectiveness of any adjustment to the Conversion Rate pursuant to Section 5.05(A), the Company will promptly send notice to the Holders, the Trustee and the Conversion Agent (if other than the Trustee) containing
(i) a brief description of the transaction or other event on account of which such adjustment was made; (ii) the Conversion Rate in effect immediately after such adjustment; and (iii) the effective time of such adjustment. 

(K) The Deferral Exception. In the event that an adjustment to the Conversion Rate otherwise required by the provisions set
forth in this Section 5.05 would result in a change of less than 1% to the Conversion Rate, then, notwithstanding anything to the contrary set forth in this Section 5.05, the Company may, at the Company’s election,
defer and carry forward such adjustment, except that all such deferred adjustments must be given effect immediately upon the earliest to occur of the following: (i) when all such deferred adjustments would result in an aggregate change of at
least 1% to the Conversion Rate; (ii) the Conversion Date of any Note; (iii) the date a Fundamental Change or Make-Whole Fundamental Change occurs; and (iv) the date the Company calls the Notes for Redemption. 

Section 5.06. Voluntary Adjustments. 

(A) Generally. To the extent permitted by law and applicable stock exchange rules, the Company, from time to time, may (but
is not required to) increase the Conversion Rate by any amount if (i) the Board of Directors determines that such increase is either (x) in the best interest of the Company; or (y) advisable to avoid or diminish any income tax imposed
on holders of Common Stock or rights to purchase Common Stock as a result of any dividend or distribution of shares (or rights to acquire shares) of Common Stock or any similar event; (ii) such increase is in effect for a period of at least
twenty (20) Business Days; and (iii) such increase is irrevocable during such period. 
 (B) Notice of Voluntary
Increases. If the Board of Directors determines to increase the Conversion Rate pursuant to Section 5.06(A), then, no later than immediately prior to the Open of Business on the first Business Day of the related twenty
(20) Business Day period referred to in Section 5.06(A), the Company will send notice to each Holder, the Trustee and the Conversion Agent of such increase, the amount thereof and the period during which such increase
will be in effect. 
 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change.

 (A) Generally. If a Make-Whole Fundamental Change occurs and the Conversion Date for the conversion of a Note occurs
during the related Make-Whole Fundamental Change Conversion Period, then, subject to this Section 5.07, the Conversion Rate applicable to such conversion will be increased by a number of shares (the “Additional Shares”)
set forth in the table below corresponding (after interpolation as provided in, and subject to, the provisions below) to the Make-Whole Fundamental Change Effective Date and the Stock Price of such Make-Whole Fundamental Change: 

 

																																									
	 Make-Whole
 Fundamental

Change Effective
	  	Stock Price	 
	Date	  	$2.72	 	  	$2.90	 	  	$3.06	 	  	$3.50	 	  	$3.98	 	  	$5.00	 	  	$6.00	 	  	$7.00	 	  	$9.00	 	  	$12.00	 
	 June 30, 2020
	  	 	40.8496	 	  	 	40.8496	 	  	 	40.8496	 	  	 	32.174	 	  	 	23.3282	 	  	 	12.1426	 	  	 	6.3693	 	  	 	3.1597	 	  	 	0.3026	 	  	 	0.0000	 
	 July 15, 2021
	  	 	40.8496	 	  	 	40.8496	 	  	 	40.8496	 	  	 	31.8597	 	  	 	22.7755	 	  	 	11.5026	 	  	 	5.8859	 	  	 	2.8312	 	  	 	0.2137	 	  	 	0.0000	 
	 July 15, 2022
	  	 	40.8496	 	  	 	40.8496	 	  	 	40.8496	 	  	 	30.6312	 	  	 	21.2931	 	  	 	10.2626	 	  	 	5.0193	 	  	 	2.2883	 	  	 	0.0804	 	  	 	0.0000	 
	 July 15, 2023
	  	 	40.8496	 	  	 	40.8496	 	  	 	40.8496	 	  	 	27.5455	 	  	 	18.2277	 	  	 	8.0026	 	  	 	3.6026	 	  	 	1.4597	 	  	 	0.0137	 	  	 	0.0000	 
	 July 15, 2024
	  	 	40.8496	 	  	 	40.8496	 	  	 	34.9019	 	  	 	20.4312	 	  	 	11.8709	 	  	 	4.2026	 	  	 	1.6026	 	  	 	0.474	 	  	 	0.0026	 	  	 	0.0000	 
	 July 15, 2025
	  	 	40.8496	 	  	 	18.0301	 	  	 	0.0000	 	  	 	0.0000	 	  	 	0.0000	 	  	 	0.0000	 	  	 	0.0000	 	  	 	0.0000	 	  	 	0.0000	 	  	 	0.0000	 

  
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 If such Make-Whole Fundamental Change Effective Date or Stock Price is not set forth in the
table above, then: 
 (i) if such Stock Price is between two Stock Prices in the table above or the Make-Whole Fundamental Change
Effective Date is between two dates in the table above, then the number of Additional Shares will be determined by straight-line interpolation between the numbers of Additional Shares set forth for the higher and lower Stock Prices in the table
above or the earlier and later dates in the table above, based on a 365- or 366-day year, as applicable; and 

(ii) if the Stock Price is greater than $12.00 (subject to adjustment in the same manner as the Stock Prices set forth in the column
headings of the table above are adjusted pursuant to Section 5.07(B)), or less than $2.72 (subject to adjustment in the same manner), per share, then no Additional Shares will be added to the Conversion Rate. 

Notwithstanding anything to the contrary in the Indenture or the Notes, in no event will the Conversion Rate be increased to an amount that
exceeds 367.6470 shares of Common Stock per $1,000 principal amount of Notes, which amount is subject to adjustment in the same manner as, and at the same time and for the same events for which, the Conversion Rate is required to be adjusted
pursuant to Section 5.05(A). In the event that the Conversion Date for the conversion of a Note occurs during a Make-Whole Fundamental Change Conversion Period relating to both a Make-Whole Fundamental Change resulting from the
Company’s calling Notes for redemption and another Make-whole Fundamental Change, then, solely for purposes of that conversion, such Conversion Date will be deemed to occur only during the period relating to the Make-Whole Fundamental Change
with the earlier Make-Whole Fundamental Change’s Effective Date. In which case, the Make-Whole Fundamental Change with the later Make-Whole Fundamental Change’s Effective Date will be deemed not to occur for purposes of such conversion.

 (B) Adjustment of Stock Prices and Number of Additional Shares. The Stock Prices in the first row (i.e., the
column headers) of the table set forth in Section 5.07(A) will be adjusted in the same manner as, and at the same time and for the same events for which, the Conversion Price is adjusted as a result of the operation
of Section 5.05(A). The numbers of Additional Shares in the table set forth in Section 5.07(A) will be adjusted in the same manner as, and at the same time and for the same events for which, the Conversion Rate
is adjusted pursuant to Section 5.05(A). 
 (C) Notice of the Occurrence of a Make-Whole Fundamental
Change. If (i) a Make-Whole Fundamental Change occurs pursuant to clause (A) of the definition thereof, then, promptly and in no event later than the Business Day immediately after the Make-Whole Fundamental Change Effective Date of
such Make-Whole Fundamental Change, the Company will notify the Holders, the Trustee and the Conversion Agent (if other than the Trustee) of the occurrence of such Make-Whole Fundamental Change and of such Make-Whole Fundamental Change Effective
Date, and (ii) a Make-Whole Fundamental Change occurs pursuant to clause (B) of the definition thereof, the Company will notify the Holders in the manner described in Section 4.03(F). The applicable notice should include
a brief statement of the circumstances under which the Conversion Rate will be increased pursuant to this Section 5.07 in connection with such Make-Whole Fundamental Change. 

Section 5.08. Effect of Common Stock Change Event. 

(A) Generally. If there occurs any: 

(i) recapitalization, reclassification or change of the Common Stock (other than (x) changes solely resulting from a subdivision or
combination of the Common Stock, (y) a change only in par value or from par value to no par value or no par value to par value or (z) stock splits and stock combinations that do not involve the issuance of any other series or class of
securities); 
 (ii) consolidation, merger, combination or binding or statutory share exchange involving the Company; 

(iii) sale, lease or other transfer of all or substantially all of the assets of the Company and its Subsidiaries, taken as a whole, to
any Person; or 
 (iv) other similar event, 

and, as a result of which, the Common Stock is converted into, or is exchanged for, or represents solely the right to receive, other securities, cash or other
property, or any combination of the foregoing (such an event, a “Common Stock Change Event,” and such other securities, cash or property, the “Reference Property,” and the amount and kind of Reference Property that
a holder of one (1) share of Common Stock would be entitled to receive on account of such Common Stock Change Event (without giving effect to any arrangement not to issue or deliver a fractional portion of any security or other property), a
“Reference Property Unit”), then, notwithstanding anything to the contrary in the Indenture or the Notes, 

  
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 (1) from and after the effective time of such Common Stock Change Event, (I) the
Conversion Consideration due upon conversion of any Note will be determined in the same manner as if each reference to any number of shares of Common Stock in this Article 5 (or in any related definitions) were instead a reference to the same number
of Reference Property Units; (II) for purposes of Section 4.03, each reference to any number of shares of Common Stock in such Section (or in any related definitions) will instead be deemed to be a reference to the same number of
Reference Property Units; and (III) for purposes of the definition of “Fundamental Change” and “Make-Whole Fundamental Change,” the terms “Common Stock” and “common equity” will be deemed to mean the
common equity, if any, forming part of such Reference Property; 
 (2) if such Reference Property Unit consists entirely of cash, then
the Company will pay the cash due in respect of all conversions whose Conversion Date occurs on or after the effective date of such Common Stock Change Event no later than the second (2nd) Business Day after the relevant Conversion Date; and 

(3) for these purposes, the Last Reported Sale Price of any Reference Property Unit or portion thereof that does not consist of a class of
securities will be the fair value of such Reference Property Unit or portion thereof, as applicable, determined in good faith by the Company (or, in the case of cash denominated in U.S. dollars, the face amount thereof). 

If the Reference Property consists of more than a single type of consideration to be determined based in part upon any form of stockholder
election, then the composition of the Reference Property Unit will be deemed to be the weighted average of the types and amounts of consideration actually received, per share of Common Stock, by the holders of Common Stock The Company will notify
Holders of such weighted average as soon as practicable after such determination is made. 
 At or before the effective time of such Common
Stock Change Event, the Company and the resulting, surviving or transferee Person (if not the Company) of such Common Stock Change Event (the “Successor Person”) will execute and deliver to the Trustee a supplemental indenture
pursuant to Section 8.01(F), which supplemental indenture will (x) provide for subsequent conversions of Notes in the manner set forth in this Section 5.08; (y) provide for subsequent adjustments to the Conversion
Rate pursuant to Section 5.05(A) in a manner consistent with this Section 5.08; and (z) contain such other provisions, if any, that the Company reasonably determines are appropriate to preserve the economic
interests of the Holders and to give effect to the provisions of this Section 5.08(A). If the Reference Property includes shares of stock or other securities or assets (other than cash) of a Person other than the Successor Person,
then such other Person will also execute such supplemental indenture and such supplemental indenture will contain such additional provisions, if any, that the Company reasonably determines are appropriate to preserve the economic interests of the
Holders. 
 (B) Notice of Common Stock Change Events. The Company will provide notice of each Common Stock Change Event to
Holders, the Trustee and the Conversion Agent (if other than the Trustee) no later than the Business Day after effective date of such Common Stock Change Event. 

(C) Compliance Covenant. The Company will not become a party to any Common Stock Change Event unless its terms are
consistent with this Section 5.08. 
 Section 5.09. Limits Upon Issuance of Shares of Common Stock Upon Conversion.

 (A) Notwithstanding anything to the contrary herein, no Person will be entitled to receive any shares of Common Stock otherwise
deliverable upon conversion of the Notes to the extent, but only to the extent, that such receipt would cause such Person to become, directly or indirectly, a Beneficial Owner of more than 9.99% of the shares of the Common Stock outstanding at such
time (such restriction, the “General Beneficial Ownership Limit”). 
 For purposes of this Section
5.09 only, a Person shall be deemed the “Beneficial Owner” of and shall be deemed to beneficially own any shares of Common Stock that such Person or any of such Person’s affiliates (as defined in Rule 12b-2 under the Exchange Act, for purposes of this Section 5.09 only, “Affiliates”)) or associates (as defined in Rule 12b-2 under the Exchange Act,
“Associates”)) is deemed to beneficially own, together with any shares of Common Stock beneficially owned by any other persons whose beneficial ownership would be aggregated with such Person for purposes of Section 13(d) of the
Exchange Act. Subject to the following proviso, for purposes of the this Section 5.09 only, beneficial ownership shall be determined in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated
thereunder as in effect on the Issue Date; provided that the number of shares of Common Stock beneficially owned by such Person and its Affiliates and Associates and any other persons whose beneficial ownership would be aggregated with such Person
for purposes of Section 13(d) of the Exchange Act shall include the number of shares of Common Stock issuable upon exercise or conversion of any of the Company’s securities or rights to acquire the Common Stock, whether or not such
securities or rights are currently exercisable or convertible or are exercisable or convertible only after the passage of time (including the number of shares of Common Stock issuable upon conversion of the Notes in respect of which the beneficial
ownership determination is being made), but shall exclude the number of shares of Common Stock that would be issuable upon (A) conversion of the remaining, unconverted portion of any Notes beneficially owned by such Person or any of its
Affiliates or Associates and any other persons whose 

  
 33 

 
beneficial ownership would be aggregated with such Person for purposes of Section 13(d) of the Exchange Act and (B) exercise or conversion of the unexercised or unconverted portion of
any of the Company’s other securities subject to a limitation on conversion or exercise analogous to the limitation contained herein beneficially owned by such Person or any of its Affiliates or Associates and any other persons whose beneficial
ownership would be aggregated with such Person for purposes of Section 13(d) of the Exchange Act. For the avoidance of doubt, the term “Beneficial Owner” as used in this Section 5.09 shall not include (i) with
respect to any Global Note, the nominee of the Depositary or any Person having an account with the Depositary or its nominee or (ii) with respect to any certificated Note, the Holder of such certificated Note unless, in each case, such nominee,
account holder or Holder shall also be a Beneficial Owner of such Note. 
 (B) In addition, a Holder at its option may elect a
beneficial ownership limit as to such Holder (but not as to any other Holder) that is less than or equal to the general beneficial ownership limit then applicable to the Holders in general upon written notice delivered to the Company prior to the
issuance of the Notes or, if thereafter, at least 61 days prior to the date of effectiveness of such lower beneficial ownership limit, specifying the percentage of shares of Common Stock for the beneficial ownership limit that shall apply to such
Holder (such beneficial ownership limit, a “Holder Beneficial Ownership Limit” and together with the general beneficial ownership limit, the “Beneficial Ownership Limits”). Written notices sent by Beneficial Owners
(or Persons who will become Beneficial Owners on the Issue Date) electing a Holder Beneficial Ownership Limit pursuant to this Section 5.09(B) received prior to the Issue Date and the issuance of the Notes are listed
on Schedule A to this Supplemental Indenture. 
 (C) Any purported delivery of shares of Common Stock upon conversion
of the Notes shall be void and have no effect to the extent, but only to the extent, that such delivery would result in any Person becoming the Beneficial Owner of shares of Common Stock outstanding at such time in excess of the Beneficial Ownership
Limits applicable to such Person. 
 (D) Unless the Company has waived the General Beneficial Ownership Limit as set forth
in Section 5.09(F) and there is no Holder Beneficial Ownership Limit applicable to a Holder, when such Holder tenders Notes for conversion, that Holder must provide a certification to the Company as to whether the Person (or
Persons) receiving shares of Common Stock upon conversion is, or would, as a result of such conversion, become the beneficial owner of shares of Common Stock outstanding at such time in excess of any beneficial ownership limit then applicable to
such Person (or Persons). 
 (E) If any delivery of shares of Common Stock otherwise owed to any Person (or persons) upon conversion of
the Notes is not made, in whole or in part, as a result of the applicable Beneficial Ownership Limits, the Company’s obligation to make such delivery shall not be extinguished and, such Holder may certify to the Company that the Person (or
Persons) receiving shares of Common Stock upon conversion is not, and would not, as a result of such conversion, become the Beneficial Owner of shares of Common Stock outstanding at such time in excess of the applicable Beneficial Ownership Limits,
after which the Company shall deliver any such shares of Common Stock withheld on account of such applicable Beneficial Ownership Limits by the later of (i) the date such shares were otherwise due to such Person (or persons) and (ii) two
trading days after receipt of such certification; provided, however, until such time as the affected Holder gives such notice, no Person shall be deemed to be the stockholder of record with respect to the shares of Common Stock otherwise
deliverable upon conversion in excess of any applicable Beneficial Ownership Limit. Upon delivery of such notice, the provisions under Section 5.09 shall apply to the shares of Common Stock to be delivered pursuant to such notice.

 (F) The Company may, at its option with the approval of the Board of Directors and subject to the applicable listing standards of The
NASDAQ Global Select Market, waive the General Beneficial Ownership Limit (as to a particular Person or as to all Persons). In the event that the Company exercises its right to waive the General Beneficial Ownership Limit to all Persons, the Company
or, at the Company’s written request and expense, the Trustee, shall deliver or cause to be delivered to each Holder 61 days prior to the effective waiver date an irrevocable notice stating that as of an effective date specified therein, the
Company waives any restrictions that limit a Holder from converting its Notes in the event that such Holder is, or would, as a result of a conversion of Notes, become, a restricted converting Holder. Any such waiver of the General Beneficial
Ownership Limit would not effect a waiver of any Holder Beneficial Ownership Limit. Neither the Trustee nor the Conversion Agent shall have any obligation to monitor the Beneficial Ownership Limit (as to a particular Person or as to all Persons) or
any of the information on Schedule A to this Supplemental Indenture, and the Trustee and the Conversion Agent may conclusively presume that the settlement method elected by the Company complies with the Beneficial Ownership Limits.

 Article 6. SUCCESSORS 

Section 6.01. When the Company May Merge, Etc. 

(A) Generally. The Company will not consolidate with or merge with or into, or (directly, or indirectly through one or more
of its Subsidiaries) sell, lease or otherwise transfer, in one transaction or a series of transactions, all or substantially all of the assets of the Company and its Subsidiaries, taken as a whole, to another Person (a “Business Combination
Event”), unless: 

  
 34 

 (i) the resulting, surviving or transferee Person either (x) is the Company or
(y) if not the Company, is a corporation (the “Successor Corporation”) duly organized and existing under the laws of the United States of America, any State thereof or the District of Columbia that expressly assumes (by
executing and delivering to the Trustee, at or before the effective time of such Business Combination Event, a supplemental indenture pursuant to Section 8.01(E)) all of the Company’s obligations under the Indenture and the
Notes; and 
 (ii) immediately after giving effect to such Business Combination Event, no Default or Event of Default will have occurred
and be continuing. 
 (B) Delivery of Officer’s Certificate and Opinion of Counsel to the Trustee. Before the
effective time of any Business Combination Event, the Company will deliver to the Trustee an Officer’s Certificate and Opinion of Counsel, each stating that (i) such Business Combination Event (and, if applicable, the related supplemental
indenture) comply with Section 6.01(A); and (ii) all conditions precedent to such Business Combination Event provided in the Indenture have been satisfied. 

Section 6.02. Successor Corporation Substituted. 

At the effective time of any Business Combination Event that complies with Section 6.01, the Successor Corporation (if not the
Company) will succeed to, and may exercise every right and power of, the Company under the Indenture and the Notes with the same effect as if such Successor Corporation had been named as the Company in the Indenture and the Notes, and, except in the
case of a lease, the predecessor Company will be discharged from its obligations under the Indenture and the Notes. 
 Article 7. DEFAULTS
AND REMEDIES 
 Section 7.01. Events of Default. 

(A) Definition of Events of Default. “Event of Default” means the occurrence of any of the following: 

(i) a default in the payment when due (whether at maturity, upon Redemption or Repurchase Upon Fundamental Change or otherwise) of the
principal of, or the Redemption Price or Fundamental Change Repurchase Price for, any Note; 
 (ii) a default for thirty (30) days
in the payment when due of interest on any Note; 
 (iii) the Company’s failure to deliver, when required by the Indenture, a
Fundamental Change Notice, or a notice pursuant to Section 5.07(C); 
 (iv) a default in the Company’s
obligation to convert a Note in accordance with Article 5 upon the exercise of the conversion right with respect thereto and such failure continues for three (3) Business days; 

(v) a default in the Company’s obligations under Article 6; 

(vi) a default in any of the Company’s obligations or agreements under the Indenture or the Notes (other than a default set forth in
clause (i), (ii), (iii), (iv) or (v) of this Section 7.01(A)) where such default is not cured or waived within sixty (60) days after notice to the Company by the Trustee, or to the Company and
the Trustee by Holders of at least twenty five percent (25%) of the aggregate principal amount of Notes then outstanding, which notice must specify such default, demand that it be remedied and state that such notice is a “Notice of
Default”; 
 (vii) a default by the Company or any of its Significant Subsidiaries with respect to any one or more mortgages,
agreements or other instruments under which there is outstanding, or by which there is secured or evidenced, any indebtedness for money borrowed of at least ten million dollars ($10,000,000) (or its foreign currency equivalent) in the aggregate of
the Company or any of its Subsidiaries, whether such indebtedness exists as of the Issue Date or is thereafter created, where such default: 

(1) constitutes a failure to pay the principal of such indebtedness when due and payable (after the expiration of all applicable grace periods) at its
stated maturity, upon required repurchase, upon declaration of acceleration or otherwise; or 

  
 35 

 (2) results in such indebtedness becoming or being declared due and payable before its stated maturity,
in each case, where such acceleration has not been rescinded or annulled or such failure to pay or default is not cured or waived, or such indebtedness is not paid or discharged in full, within thirty (30) days after notice to the Company by
the Trustee or to the Company and the Trustee by Holders of at least twenty five percent (25%) of the aggregate principal amount of Notes then outstanding; 

(viii) one or more final judgments being rendered against the Company or any of its Significant Subsidiaries for the payment of at least
ten million dollars ($10,000,000) (or its foreign currency equivalent) in the aggregate (excluding any amounts covered by insurance), where such judgment is not discharged or stayed within sixty (60) days after (i) the date on which the
right to appeal the same has expired, if no such appeal has commenced; or (ii) the date on which all rights to appeal have been extinguished; 

(ix) the Company or any of its Significant Subsidiaries, pursuant to or within the meaning of any Bankruptcy Law, either: 

(1) commences a voluntary case or proceeding; 

(2) consents to the entry of an order for relief against it in an involuntary case or proceeding; 

(3) consents to the appointment of a custodian of it or for any substantial part of its property; 

(4) makes a general assignment for the benefit of its creditors; 

(5) takes any comparable action under any foreign Bankruptcy Law; or 

(6) generally is not paying its debts as they become due; or 

(x) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that either: 

(1) is for relief against the Company or any of its Significant Subsidiaries in an involuntary case or proceeding; 

(2) appoints a custodian of the Company or any of its Significant Subsidiaries, or for any substantial part of the property of the Company
or any of its Significant Subsidiaries; 
 (3) orders the winding up or liquidation of the Company or any of its Significant
Subsidiaries; or 
 (4) grants any similar relief under any foreign Bankruptcy Law, 

and, in each case under this Section 7.01(A)(x), such order or decree remains unstayed and in effect for at least sixty
(60) days. 
 (B) Cause Irrelevant. Each of the events set forth in Section 7.01(A) will
constitute an Event of Default regardless of the cause thereof or whether voluntary or involuntary or effected by operation of law or pursuant to any judgment, decree or order of any court or any order, rule or regulation of any administrative or
governmental body. 
 Section 7.02. Acceleration. 

(A) Automatic Acceleration in Certain Circumstances. If an Event of Default set forth in Section
7.01(A)(ix) or 7.01(A)(x) occurs with respect to the Company (and not solely with respect to a Significant Subsidiary of the Company), then the principal amount of, and all accrued and unpaid interest on,
all of the Notes then outstanding will immediately become due and payable without any further action or notice by any Person. 

(B) Optional Acceleration. Subject to Section 7.03, if an Event of Default (other than an Event of Default set
forth in Section 7.01(A)(ix) or 7.01(A)(x) with respect to the Company and not solely with respect to a Significant Subsidiary of the Company) occurs and is continuing, then the Trustee, by notice
to the Company, or Holders of at least twenty five percent (25%) of the aggregate principal amount of Notes then outstanding, by notice to the Company and the Trustee, may declare the principal amount of, and all accrued and unpaid interest on, all
of the Notes then outstanding to become due and payable immediately. 

  
 36 

 (C) Rescission of Acceleration. Notwithstanding anything to the contrary
in the Indenture or the Notes, the Holders of a majority in aggregate principal amount of the Notes then outstanding, by notice to the Company and the Trustee, may, on behalf of all Holders, rescind any acceleration of the Notes and its consequences
if (i) such rescission would not conflict with any judgment or decree of a court of competent jurisdiction; and (ii) all existing Events of Default (except the non-payment of principal of, or
interest on, the Notes that has become due solely because of such acceleration) have been cured or waived. No such rescission will affect any subsequent Default or impair any right consequent thereto. 

Section 7.03. Sole Remedy for a Failure to Report. 

(A) Generally. Notwithstanding anything to the contrary in the Indenture or the Notes, the Company may elect that the sole
remedy for any Event of Default (a “Reporting Event of Default”) pursuant to Section 7.01(A)(vi) arising from the Company’s failure to comply with Section 3.02 (including
Section 314(a)(1) of the Trust Indenture Act) will, for each of the first 360 calendar days on which a Reporting Event of Default has occurred and is continuing, consist exclusively of the accrual of Special Interest on the Notes. If the
Company has made such an election, then (i) the Notes will be subject to acceleration pursuant to Section 7.02 on account of the relevant Reporting Event of Default from, and including, the 361st calendar day on which a
Reporting Event of Default has occurred and is continuing or if the Company fails to pay any accrued and unpaid Special Interest when due; and (ii) Special Interest will cease to accrue on any Notes from, and including, the earlier of
(x) the date such Event of Default is cured or waived and (y) such 361st calendar day (it being understood that interest on any defaulted Special Interest will nonetheless accrue pursuant to Section 2.05(B)). 

(B) Amount and Payment of Special Interest. Any Special Interest that accrues on a Note pursuant to Section
7.03(A) will be payable on the same dates and in the same manner as the Stated Interest on such Note and will accrue at a rate per annum equal to one quarter of one percent (0.25%) of the principal amount thereof for the first one hundred
and eighty (180) days on which Special Interest accrues and, thereafter, at a rate per annum equal to one half of one percent (0.50%) of the principal amount thereof for the next one hundred and eighty (180) days on which Special Interest
accrues; provided, however, that in no event will Special Interest, accrue on any day on a Note at a rate per annum that exceeds one half of one percent (0.50%) regardless of the number of events or circumstances giving rise
to the accrual of Special Interest. 
 (C) Notice of Election. To make the election set forth in Section
7.03(A), the Company must send to the Holders, the Trustee and the Paying Agent, before the date on which each Reporting Event of Default first occurs, a notice that (i) briefly describes the report(s) that the Company failed to file
with the SEC; (ii) states that the Company is electing that the sole remedy for such Reporting Event of Default consist of the accrual of Special Interest; and (iii) briefly describes the periods during which and rate at which Special
Interest will accrue and the circumstances under which the Notes will be subject to acceleration on account of such Reporting Event of Default. For the avoidance of doubt, if the Company’s failure to file or furnish a report as described
in Section 3.02(A), within the time period specified in Section 3.02(A), results in a Default or a Reporting Event of Default, such Default or Reporting Event of Default will be cured by the subsequent filing or
furnishing of such report. 
 (D) Notice to Trustee and Paying Agent; Trustee’s Disclaimer. If Special Interest
accrues on any Note, then, no later than five (5) Business Days before each date on which such Special Interest is to be paid, the Company will deliver an Officer’s Certificate to the Trustee and the Paying Agent stating (i) that the
Company is obligated to pay Special Interest on such Note on such date of payment; and (ii) the amount of such Special Interest that is payable on such date of payment. The Trustee will have no duty to determine whether any Special Interest is
payable or the amount thereof. 
 (E) No Effect on Other Events of Default. No election pursuant to this Section
7.03 with respect to a Reporting Event of Default will affect the rights of any Holder with respect to any other Event of Default, including with respect to any other Reporting Event of Default. 

Section 7.04. Other Remedies. 

(A) Trustee May Pursue All Remedies. If an Event of Default occurs and is continuing, then the Trustee may pursue any
available remedy to collect the payment of any amounts due with respect to the Notes or to enforce the performance of any provision of the Indenture or the Notes. 

(B) Procedural Matters. The Trustee may maintain a proceeding even if it does not possess any of the Notes or does not
produce any of them in such proceeding. A delay or omission by the Trustee or any Holder in exercising any right or remedy following an Event of Default will not impair the right or remedy or constitute a waiver of, or acquiescence in, such Event of
Default. All remedies will be cumulative to the extent permitted by law. 

  
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 Section 7.05. Waiver of Past Defaults. 

An Event of Default pursuant to clause (i), (ii), (iv) or (vi) of Section 7.01(A) (that, in the
case of clause (vi) only, results from a Default under any covenant that cannot be amended without the consent of each affected Holder), and a Default that could lead to such an Event of Default, can be waived only with the consent of each
affected Holder. Each other Default or Event of Default may be waived, on behalf of all Holders, by the Holders of a majority in aggregate principal amount of the Notes then outstanding. If an Event of Default is so waived, then it will cease to
exist. If a Default is so waived, then it will be deemed to be cured and any Event of Default arising therefrom will be deemed not to occur. However, no such waiver will extend to any subsequent or other Default or Event of Default or impair any
right arising therefrom. 
 Section 7.06. Control by Majority. 

Holders of a majority in aggregate principal amount of the Notes then outstanding may direct the time, method and place of conducting any
proceeding for exercising any remedy available to the Trustee or exercising any trust or power conferred on it. However, the Trustee may refuse to follow any direction that conflicts with law, the Indenture or the Notes, or that, subject
to Section 10.01, the Trustee determines may be unduly prejudicial to the rights of other Holders or may involve the Trustee in liability, unless the Trustee is offered, and, if requested, provided, security and indemnity satisfactory to
the Trustee against any loss, liability or expense to the Trustee that may result from the Trustee’s following such direction. 
 Section 7.07.
Limitation on Suits. 
 No Holder may pursue any remedy with respect to the Indenture or the Notes (except to enforce (x) its rights
to receive the principal of, or the Redemption Price or Fundamental Change Repurchase Price for, or interest on, any Notes; or (y) the Company’s obligations to convert any Notes pursuant to Article 5), unless: 

(A) such Holder has previously delivered to the Trustee notice that an Event of Default is continuing; 

(B) Holders of at least twenty five percent (25%) in aggregate principal amount of the Notes then outstanding deliver a request to the
Trustee to pursue such remedy; 
 (C) such Holder or Holders offer and, if requested, provide to the Trustee security and indemnity
satisfactory to the Trustee against any loss, liability or expense to the Trustee that may result from the Trustee’s following such request; 

(D) the Trustee does not comply with such request within sixty (60) calendar days after its receipt of such request and such offer of
security or indemnity; and 
 (E) during such sixty (60) calendar day period, Holders of a majority in aggregate principal amount
of the Notes then outstanding do not deliver to the Trustee a direction that is inconsistent with such request. 
 A Holder of a Note may
not use the Indenture to prejudice the rights of another Holder or to obtain a preference or priority over another Holder. The Trustee will have no duty to determine whether any Holder’s use of the Indenture complies with the preceding
sentence. 
 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and
Conversion Consideration. 
 Notwithstanding anything to the contrary in the Indenture or the Notes (but without limiting Section
8.01), the right of each Holder of a Note to bring suit for the enforcement of any payment or delivery, as applicable, of the principal of, or the Redemption Price or Fundamental Change Repurchase Price for, or any interest on, or the Conversion
Consideration due pursuant to Article 5 upon conversion of, such Note on or after the respective due dates therefor provided in the Indenture and the Notes, will not be impaired or affected without the consent of such Holder. 

Section 7.09. Collection Suit by Trustee. 

The Trustee will have the right, upon the occurrence and continuance of an Event of Default pursuant to clause (i), (ii) or
(iv) of Section 7.01(A), to recover judgment in its own name and as trustee of an express trust against the Company for the total unpaid or undelivered principal of, or Redemption Price or Fundamental Change Repurchase
Price for, or interest on, or Conversion Consideration due pursuant to Article 5 upon conversion of, the Notes, as applicable, and, to the extent lawful, any Default Interest on any Defaulted Amounts, and such further amounts sufficient to cover the
costs and expenses of collection, including compensation provided for in Section 7.06 of the Base Indenture. 

  
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 Section 7.10. Trustee May File Proofs of Claim. 

The Trustee has the right to (A) file such proofs of claim and other papers or documents as may be necessary or advisable in order to have
the claims of the Trustee and the Holders allowed in any judicial proceedings relative to the Company (or any other obligor upon the Notes) or its creditors or property and (B) collect, receive and distribute any money or other property payable
or deliverable on any such claims. Each Holder authorizes any custodian in such proceeding to make such payments to the Trustee, and, if the Trustee consents to the making of such payments directly to the Holders, to pay to the Trustee any amount
due to the Trustee for the reasonable compensation, expenses, disbursements and advances of the Trustee, and its agents and counsel, and any other amounts payable to the Trustee pursuant to Section 7.06 of the Base Indenture. To the
extent that the payment of any such compensation, expenses, disbursements, advances and other amounts out of the estate in such proceeding, is denied for any reason, payment of the same will be secured by a lien on, and will be paid out of, any and
all distributions, dividends, money, securities and other properties that the Holders may be entitled to receive in such proceeding (whether in liquidation or under any plan of reorganization or arrangement or otherwise). Nothing in the Indenture
will be deemed to authorize the Trustee to authorize, consent to, accept or adopt on behalf of any Holder any plan of reorganization, arrangement, adjustment or composition affecting the Notes or the rights of any Holder, or to authorize the Trustee
to vote in respect of the claim of any Holder in any such proceeding. 
 Section 7.11. Priorities. 

The Trustee will pay or deliver in the following order any money or other property that it collects pursuant to this Article 7: 

First: to the Trustee, each Note Agent and its agents and attorneys for amounts due under Section 7.06 of the Base
Indenture, including payment of all fees, compensation, expenses and liabilities incurred, and all advances made, by the Trustee and the Note Agents and the costs and expenses of collection; 

Second: to Holders for unpaid amounts or other property due on the Notes, including the principal of, or the Redemption Price or
Fundamental Change Repurchase Price for, or any interest on, or any Conversion Consideration due upon conversion of, the Notes, ratably, and without preference or priority of any kind, according to such amounts or other property due and payable on
all of the Notes; and 
 Third: to the Company or such other Person as a court of competent jurisdiction directs. 

The Trustee may fix a record date and payment date for any payment or delivery to the Holders pursuant to this Section 7.11, in
which case the Trustee will instruct the Company to, and the Company will, deliver, at least fifteen (15) calendar days before such record date, to each Holder and the Trustee a notice stating such record date, such payment date and the amount
of such payment or nature of such delivery, as applicable. 
 Section 7.12. Undertaking for Costs. 

In any suit for the enforcement of any right or remedy under the Indenture or the Notes or in any suit against the Trustee for any action taken
or omitted by it as Trustee, a court, in its discretion, may (A) require the filing by any litigant party in such suit of an undertaking to pay the costs of such suit, and (B) assess reasonable costs (including reasonable attorneys’
fees) against any litigant party in such suit, having due regard to the merits and good faith of the claims or defenses made by such litigant party; provided, however, that this Section 7.12 does not apply to
any suit by the Trustee, any suit by a Holder pursuant to Section 7.08 or any suit by one or more Holders of more than ten percent (10%) in aggregate principal amount of the Notes then outstanding. 

Section 7.13. Trustee’s Obligation to Provide Notice of Defaults to Holders. 

If a Default or an Event of Default occurs and is continuing and the Trustee receives written notice thereof, then the Trustee must notify
Holders of the same within ninety (90) days after it receives such notice. 

  
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 Article 8. AMENDMENTS, SUPPLEMENTS AND WAIVERS 

Section 8.01. Without the Consent of Holders. 

Notwithstanding anything to the contrary in Section 8.02, the Company and the Trustee may amend or supplement the Indenture or the
Notes without the consent of any Holder to: 
 (A) cure any ambiguity or correct any omission, defect or inconsistency in the Indenture
or the Notes; 
 (B) add guarantees with respect to the Company’s obligations under the Indenture or the Notes; 

(C) secure the Notes; 

(D) add to the Company’s covenants or Events of Default for the benefit of the Holders or surrender any right or power conferred on
the Company; 
 (E) provide for the assumption of the Company’s obligations under the Indenture and the Notes pursuant to, and in
compliance with, Article 6; 
 (F) enter into supplemental indentures pursuant to, and in accordance with, Section
5.08 in connection with a Common Stock Change Event; 
 (G) evidence or provide for the acceptance of the appointment, under
the Indenture, of a successor Trustee; 
 (H) conform the provisions of the Indenture and the Notes to the “Description of
Notes” section of the Company’s preliminary prospectus supplement, dated June 24, 2020 as supplemented by the related pricing term sheet, dated June 25, 2020; 

(I) provide for or confirm the issuance of additional Notes pursuant to Section 2.03(B); 

(J) increase the conversion rate as provided in the indenture; 

(K) comply with any requirement of the SEC in connection with any qualification of the Indenture or any supplemental indenture thereto,
under the Trust Indenture Act, as then in effect; or 
 (L) make any other change to the Indenture or the forms or terms of the Notes;
provided that no such change, individually or in the aggregate with all other such changes, adversely affect the rights of the Holders. 

At the written request of any Holder of a Note or owner of a beneficial interest in a Global Note, the Company will provide a copy of the
“Description of Notes” section and pricing term sheet referred to in Section 8.01(H). 
 Section 8.02. With the Consent
of Holders. 
 (A) Generally. Subject to Sections
8.01, 7.05 and 7.08 and the immediately following sentence, the Company and the Trustee may, with the consent of the Holders of a majority in aggregate principal amount of the Notes then outstanding, amend or
supplement the Indenture or the Notes or waive compliance with any provision of the Indenture or the Notes. Notwithstanding anything to the contrary in the foregoing sentence, but subject to Section 8.01, without the consent of each
affected Holder, no amendment or supplement to the Indenture or the Notes, or waiver of any provision of the Indenture or the Notes, may: 

(i) reduce the principal, or extend the stated maturity, of any Note; 

(ii) reduce the Redemption Price or Fundamental Change Repurchase Price for any Note or change the times at which, or the circumstances
under which, the Notes may or will be redeemed or repurchased by the Company; 
 (iii) reduce the rate, or extend the time for the
payment, of interest on any Note; 
 (iv) make any change that adversely affects the conversion rights of any Note; 

(v) impair the rights of any Holder set forth in Section 7.08 (as such section is in effect on the Issue Date); 

  
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 (vi) change the ranking of the Notes; 

(vii) make any Note payable in money, or at a place of payment, other than that stated in the Indenture or the Note; 

(viii) reduce the amount of Notes whose Holders must consent to any amendment, supplement, waiver or other modification; or 

(ix) make any direct or indirect change to any amendment, supplement, waiver or modification provision of the Indenture or the Notes that
requires the consent of each affected Holder. 
 For the avoidance of doubt, pursuant to clauses (i), (ii), (iii) and
(iv) of this Section 8.02(A), no amendment or supplement to the Indenture or the Notes, or waiver of any provision of the Indenture or the Notes, may change the amount or type of consideration due on any Note (whether
on an Interest Payment Date, Redemption Date, Fundamental Change Repurchase Date or the Maturity Date or upon conversion, or otherwise), or the date(s) or time(s) such consideration is payable or deliverable, as applicable, without the consent of
each affected Holder. 
 (B) Holders Need Not Approve the Particular Form of any Amendment. A consent of any Holder
pursuant to this Section 8.02 need approve only the substance, and not necessarily the particular form, of the proposed amendment, supplement or waiver. 

Section 8.03. Notice of Amendments, Supplements and Waivers. 

As soon as reasonably practicable after any amendment, supplement or waiver pursuant to Section
8.01 or 8.02 becomes effective, the Company will send to the Holders and the Trustee notice that (A) describes the substance of such amendment, supplement or waiver in reasonable detail and (B) states the
effective date thereof; provided, however, that the Company will not be required to provide such notice to the Holders if such amendment, supplement or waiver is included in a current or periodic report filed by the Company
with the SEC within four (4) Business Days of its effectiveness. The failure to send, or the existence of any defect in, such notice will not impair or affect the validity of such amendment, supplement or waiver. 

Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 

(A) Revocation and Effect of Consents. The consent of a Holder of a Note to an amendment, supplement or waiver will bind
(and constitute the consent of) each subsequent Holder of any Note to the extent the same evidences any portion of the same indebtedness as the consenting Holder’s Note, subject to the right of any Holder of a Note to revoke (if not prohibited
pursuant to Section 8.04(B)) any such consent with respect to such Note by delivering notice of revocation to the Company (or its agent) or the Trustee before the time such amendment, supplement or waiver becomes effective. 

(B) Special Record Dates. The Company may, but is not required to, fix a record date for the purpose of determining the
Holders entitled to consent or take any other action in connection with any amendment, supplement or waiver pursuant to this Article 8. If a record date is fixed, then, notwithstanding anything to the contrary in Section 8.04(A),
only Persons who are Holders as of such record date (or their duly designated proxies) will be entitled to give such consent, to revoke any consent previously given or to take any such action, regardless of whether such Persons continue to be
Holders after such record date; provided, however, that no such consent will be valid or effective for more than one hundred and twenty (120) calendar days after such record date. 

(C) Solicitation of Consents. For the avoidance of doubt, each reference in the Indenture or the Notes to the consent of a
Holder will be deemed to include any such consent obtained in connection with a repurchase of, or tender or exchange offer for, any Notes. 

(D) Effectiveness and Binding Effect. Each amendment, supplement or waiver pursuant to this Article 8 will become effective
in accordance with its terms and, when it becomes effective with respect to any Note (or any portion thereof), will thereafter bind every Holder of such Note (or such portion). 

Section 8.05. Notations and Exchanges. 

If any amendment, supplement or waiver changes the terms of a Note, then the Trustee or the Company may, in its discretion, require the Holder
of such Note to deliver such Note to the Trustee so that the Trustee may place an appropriate notation prepared by the Company on such Note and return such Note to such Holder. Alternatively, at its discretion, the Company may, in exchange for such
Note, issue, execute and deliver, and the Trustee will authenticate, in each case in accordance with Section 2.02, a new Note that reflects the changed terms. The failure to make any appropriate notation or issue a new Note pursuant to
this Section 8.05 will not impair or affect the validity of such amendment, supplement or waiver. 

  
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 Section 8.06. Trustee to Execute Supplemental Indentures. 

The Trustee will execute and deliver any amendment or supplemental indenture authorized pursuant to this Article
8; provided, however, that the Trustee need not (but may, in its sole and absolute discretion) execute or deliver any such amendment or supplemental indenture that adversely affects the Trustee’s rights, duties,
liabilities or immunities. In executing any amendment or supplemental indenture, the Trustee will be entitled to receive, and (subject to Sections 7.01 and 7.02 of the Base Indenture) will be fully protected in relying on, an
Officer’s Certificate and an Opinion of Counsel stating that (A) the execution and delivery of such amendment or supplemental indenture is authorized or permitted by the Indenture; and (B) in the case of the Opinion of Counsel, such
amendment or supplemental indenture is valid, binding and enforceable against the Company in accordance with its terms. 
 Article 9.
SATISFACTION AND DISCHARGE 
 Section 9.01. Termination of Company’s Obligations. 

This Indenture will be discharged, and will cease to be of further effect as to all Notes issued under the Indenture, when: 

(A) all Notes then outstanding (other than Notes replaced pursuant to Section 2.12) have (i) been delivered to the
Trustee for cancellation; or (ii) become due and payable (whether on a Redemption Date, a Fundamental Change Repurchase Date, the Maturity Date, upon conversion or otherwise) for an amount of cash or Conversion Consideration, as applicable,
that has been fixed; 
 (B) the Company has caused there to be irrevocably deposited with the Trustee, or with the Paying Agent (or,
with respect to Conversion Consideration, the Holders), in each case for the benefit of the Holders, or has otherwise caused there to be delivered to the Holders, cash (or, with respect to Notes to be converted, Conversion Consideration) sufficient
to satisfy all amounts or other property due on all Notes then outstanding (other than Notes replaced pursuant to Section 2.12); 

(C) the Company has paid all other amounts payable by it under the Indenture with respect to the Notes; and 

(D) the Company has delivered to the Trustee an Officer’s Certificate and an Opinion of Counsel, each stating that the conditions
precedent to the discharge of the Indenture have been satisfied; 
 provided, however, that Article 7 of the Base
Indenture] and Section 11.01 will survive such discharge and, until no Notes remain outstanding, Section 2.14 and the obligations of the Trustee, the Paying Agent and the Conversion Agent with respect to
money or other property deposited with them will survive such discharge. 
 At the Company’s request, the Trustee will acknowledge the
satisfaction and discharge of the Indenture. 
 Section 9.02. Repayment to Company. 

Subject to applicable unclaimed property law, the Trustee, the Paying Agent and the Conversion Agent will promptly notify the Company if there
exists (and, at the Company’s request, promptly deliver to the Company) any cash, Conversion Consideration or other property held by any of them for payment or delivery on the Notes that remain unclaimed two (2) years after the date on
which such payment or delivery was due. After such delivery to the Company, the Trustee, the Paying Agent and the Conversion Agent will have no further liability to any Holder with respect to such cash, Conversion Consideration or other property,
and Holders entitled to the payment or delivery of such cash, Conversion Consideration or other property must look to the Company for payment as a general creditor of the Company. 

Section 9.03. Reinstatement. 
 If the
Trustee, the Paying Agent or the Conversion Agent is unable to apply any cash or other property deposited with it pursuant to Section 9.01 because of any legal proceeding or any order or judgment of any court or other governmental
authority that enjoins, restrains or otherwise prohibits such application, then the discharge of the Indenture pursuant to Section 9.01 will be rescinded; provided, however, that if the Company thereafter
pays or delivers any cash or other property due on the Notes to the Holders thereof, then the Company will be subrogated to the rights of such Holders to receive such cash or other property from the cash or other property, if any, held by the
Trustee, the Paying Agent or the Conversion Agent, as applicable. 

  
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 Article 10. TRUSTEE 

Section 10.01. Duties of the Trustee. 

(A) If an Event of Default has occurred and is continuing, the Trustee will exercise such of the rights and powers vested in it by the
Indenture, and use the same degree of care and skill in its exercise, as a prudent person would exercise or use under the circumstances in the conduct of such person’s own affairs; provided that the Trustee will be under no
obligation to exercise any of the rights or powers under this Indenture at the request or direction of any of the Holders unless such Holders have offered, and if requested, provided, to the Trustee indemnity or security satisfactory to Trustee
against any loss, liability or expense that might be incurred by it in compliance with such request or direction. 
 (B) Except during
the continuance of an Event of Default: 
 (i) the duties of the Trustee will be determined solely by the express provisions of the
Indenture, and the Trustee need perform only those duties that are specifically set forth in the Indenture and no others, and no implied covenants or obligations will be read into the Indenture against the Trustee; and 

(ii) in the absence of bad faith or willful misconduct on its part, the Trustee may conclusively rely, as to the truth of the statements
and the correctness of the opinions expressed therein, upon Officer’s Certificates or Opinions of Counsel that are provided to the Trustee and conform to the requirements of the Indenture. However, the Trustee will examine the certificates and
opinions to determine whether or not they conform to the requirements of the Indenture (but need not confirm or investigate the accuracy of mathematical calculations or other facts stated therein). 

(C) The Trustee may not be relieved from liabilities for its negligence or willful misconduct, except that: 

(i) this paragraph will not limit the effect of Section 10.01(B); 

(ii) the Trustee will not be liable for any error of judgment made in good faith by a Responsible Officer, unless it is proved that the
Trustee was negligent in ascertaining the pertinent facts; and 
 (iii) the Trustee will not be liable with respect to any action it
takes or omits to take in good faith in accordance with a direction received by it pursuant to Section 7.06. 
 (D) Each
provision of the Indenture that in any way relates to the Trustee is subject to paragraphs (A), (B) and (C) of this Section 10.01, regardless of whether such provision so expressly provides. 

(E) No provision of the Indenture will require the Trustee to expend or risk its own funds or incur any liability. 

(F) Whether or not therein provided, every provision of this Indenture relating to the conduct or affecting the liability of, or affording
protection to, the Trustee shall be subject to the provisions of this Section. 
 (G) The Trustee shall not be liable in respect of any
payment (as to the correctness of amount, entitlement to receive or any other matters relating to payment) or notice effected by the Company or any Paying Agent (except in its capacity as Paying Agent pursuant to the terms of this Indenture) or any
records maintained by any co-Note Registrar with respect to the Notes. 
 (H) If any party fails
to deliver a notice relating to an event the fact of which, pursuant to this Indenture, requires notice to be sent to the Trustee, the Trustee may conclusively rely on its failure to receive such notice as reason to act as if no such event occurred,
unless a Responsible Officer of the Trustee had actual knowledge of such event. 
 (I) Under no circumstances shall the Trustee be
liable in its individual capacity for the obligations evidenced by the Notes. 
 (J) The Trustee will not be liable for interest on any
money received by it, except as the Trustee may agree in writing with the Company. Money held in trust by the Trustee need not be segregated from other funds, except to the extent required by law. 

  
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 Section 10.02. Rights of the Trustee. 

(A) The Trustee may conclusively rely on any document that it believes to be genuine and signed or presented by the proper Person, and the
Trustee need not investigate any fact or matter stated in such document.

 
 (B) Any request, direction, order or demand of the Company mentioned herein shall be sufficiently
evidenced by an Officer’s Certificate (unless other evidence in respect thereof be herein specifically prescribed); and any Board Resolution may be evidenced to the Trustee by a copy thereof certified by the Secretary or an Assistant Secretary
of the Company. Before the Trustee acts or refrains from acting, it may require an Officer’s Certificate, an Opinion of Counsel or both. The Trustee will not be liable for any action it takes or omits to take in good faith in reliance on such
Officer’s Certificate or Opinion of Counsel. The Trustee may consult with counsel; and the written advice of such counsel, or any Opinion of Counsel, will constitute full and complete authorization of the Trustee to take or omit to take any
action in good faith in reliance thereon without liability. 
 (C) The Trustee may act through its attorneys and agents and will not be
responsible for the misconduct or negligence of any such agent appointed with due care. 
 (D) The Trustee will not be liable for any
action it takes or omits to take in good faith and that it believes to be authorized or within the rights or powers vested in it by the Indenture. 

(E) Unless otherwise specifically provided in the Indenture, any demand, request, direction or notice from the Company will be sufficient
if signed by an Officer of the Company. 
 (F) The Trustee need not exercise any rights or powers vested in it by the Indenture at the
request or direction of any Holder unless such Holder has offered, and if requested, provided to the Trustee security or indemnity satisfactory to the Trustee against any loss, liability or expense that it may incur in complying with such request or
direction. 
 (G) The Trustee will not be responsible or liable for any punitive, special, indirect or consequential loss or damage
(including lost profits), even if the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action. 

(H) The Trustee shall not be deemed to have notice of a Default or Event of Default unless a Responsible Officer of the Trustee has actual
knowledge of such Default or Event of Default or unless written notice of any event that is in fact such a Default or Event of Default is received by a Responsible Officer of the Trustee at the Corporate Trust Office of the Trustee, and such notice
references the Notes and the Indenture. 
 (I) The rights, privileges, protections, immunities and benefits given to the Trustee,
including, its right to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each Agent, custodian and other Person employed to act hereunder. 

(J) The Trustee shall not be required to give any bond or surety or to expend or risk its own funds in respect of the performance of its
powers and duties hereunder. 
 (K) The Trustee shall not be liable or responsible for any action or inaction of any clearinghouse or
depositary. 
 (L) The Trustee will not be bound to make any investigation into the facts or matters stated in any resolution,
certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document, but the Trustee, in its discretion, may make such further inquiry or
investigation into such facts or matters as it may see fit, and the Trustee will incur no liability or additional liability of any kind by reason of such inquiry or investigation. 

(M) The Trustee may request that the Company deliver a certificate setting forth the names of individuals or titles of officers authorized
at such time to take specified actions pursuant to this Indenture. 
 (N) The permissive rights of the Trustee enumerated herein shall
not be construed as duties. 
 Section 10.03. Individual Rights of the Trustee. 

The Trustee, in its individual or any other capacity, may become the owner or pledgee of any Note and may otherwise deal with the Company or
any of its Affiliates with the same rights that it would have if it were not Trustee; provided, however, that if the Trustee acquires a “conflicting interest” (within the meaning of Section 310(b) of the Trust
Indenture Act), then it must eliminate such conflict within ninety (90) days or resign as Trustee. Each Note Agent will have the same rights and duties as the Trustee under this Section 10.03. 

  
 44 

 Section 10.04. Trustee’s Disclaimer. 

The Trustee will not be (A) responsible for, and makes no representation as to, the validity or adequacy of the Indenture or the Notes;
(B) accountable for the Company’s use of the proceeds from the Notes or any money paid to the Company or upon the Company’s direction under any provision of the Indenture; (C) responsible for the use or application of any money
received by any Paying Agent other than the Trustee; and (D) responsible for any statement or recital in the Indenture, the Notes or any other document relating to the sale of the Notes or the Indenture, other than the Trustee’s
certificate of authentication. 
 Section 10.05 Notice of Defaults. 

If a Default or Event of Default occurs and is continuing and is known to a Responsible Officer of the Trustee, then the Trustee will send
Holders a notice of such Default or Event of Default within ninety (90) days after it occurs or, if it is not known to a Responsible Officer of the Trustee at such time, promptly (and in any event within ten (10) Business Days) after it
becomes known to a Responsible Officer; provided, however, that, except in the case of a Default or Event of Default in the payment of the principal of, or interest on, any Note, the Trustee may withhold such notice if and
for so long as it in good faith determines that withholding such notice is in the interests of the Holders. 
 Section 10.06. Compensation and
Indemnity. 
 (A) The Company will, from time to time, pay the Trustee and the Note Agents reasonable compensation for its
acceptance of the Indenture and services under the Indenture. The Trustee’s compensation will not be limited by any law on compensation of a trustee of an express trust. In addition to the compensation for the Trustee’s services, the
Company will reimburse the Trustee promptly upon request for all reasonable disbursements, advances and expenses incurred or made by it under the Indenture, including the reasonable compensation, disbursements and expenses of the Trustee’s
agents and counsel. 
 (B) The Company will indemnify the Trustee against any and all losses, liabilities or expenses incurred by it
arising out of or in connection with the acceptance or administration of its duties under the Indenture, including the costs and expenses of enforcing the Indenture against the Company (including this Section 10.06) and defending itself
against any claim (whether asserted by the Company, any Holder or any other Person) or liability in connection with the exercise or performance of any of its powers or duties under the Indenture, except to the extent any such loss, liability or
expense may be attributable to its negligence or willful misconduct, as determined by a final, nonappealable order of a court of competent jurisdiction. The Trustee will promptly notify the Company of any claim for which it may seek indemnity, but
the Trustee’s failure to so notify the Company will not relieve the Company of its obligations under this Section 10.06(B), except to the extent the Company is materially prejudiced by such failure. The Company will defend
such claim, and the Trustee will cooperate in such defense. If the Trustee is advised by counsel that it may have defenses available to it that are in conflict with the defenses available to the Company, or that there is an actual or potential
conflict of interest, then the Trustee may retain separate counsel, and the Company will pay the reasonable fees and expenses of such counsel (including the reasonable fees and expenses of counsel to the Trustee incurred in evaluating whether such a
conflict exists). The Company need not pay for any settlement of any such claim made without its consent, which consent will not be unreasonably withheld. 

(C) The obligations of the Company under this Section 10.06 will survive the resignation or removal of the Trustee and
the discharge of the Indenture. 
 (D) To secure the Company’s payment obligations in this Section 10.06, the Trustee
will have a lien prior to the Notes on all money or property held or collected by the Trustee, except that held in trust to pay principal of, or interest on, particular Notes, which lien will survive the discharge of the Indenture. 

(E) If the Trustee incurs expenses or renders services after an Event of Default pursuant to clause (ix) or (x)
of Section 7.01(A) occurs, then such expenses and the compensation for such services (including the fees and expenses of its agents and counsel) are intended to constitute expenses of administration under any Bankruptcy Law. 

Section 10.07. Replacement of the Trustee. 

(A) Notwithstanding anything to the contrary in this Section 10.07, a resignation or removal of the Trustee, and the
appointment of a successor Trustee, will become effective only upon such successor Trustee’s acceptance of appointment as provided in this Section 10.07. 

  
 45 

 (B) The Trustee may resign at any time and be discharged from the trust created by the
Indenture by so notifying the Company. The Holders of a majority in aggregate principal amount of the Notes then outstanding may remove the Trustee by so notifying the Trustee and the Company in writing. The Company may remove the Trustee if: 

(i) the Trustee fails to comply with Section 10.09; 

(ii) the Trustee is adjudged to be bankrupt or insolvent or an order for relief is entered with respect to the Trustee under any
Bankruptcy Law; 
 (iii) a custodian or public officer takes charge of the Trustee or its property; or 

(iv) the Trustee becomes incapable of acting. 

(C) If the Trustee resigns or is removed, or if a vacancy exists in the office of Trustee for any reason, then (i) the Company will
promptly appoint a successor Trustee; and (ii) at any time within one (1) year after the successor Trustee takes office, the Holders of a majority in aggregate principal amount of the Notes then outstanding may appoint a successor Trustee
to replace such successor Trustee appointed by the Company. 
 (D) If a successor Trustee does not take office within sixty
(60) days after the retiring Trustee resigns or is removed, then the retiring Trustee, the Company or the Holders of at least ten percent (10%) in aggregate principal amount of the Notes then outstanding may petition any court of competent
jurisdiction for the appointment of a successor Trustee. 
 (E) If the Trustee, after written request by a Holder of at least six
(6) months, fails to comply with Section 10.09, then such Holder may petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee. 

(F) A successor Trustee will deliver a written acceptance of its appointment to the retiring Trustee and to the Company, upon which notice
the resignation or removal of the retiring Trustee will become effective and the successor Trustee will have all the rights, powers and duties of the Trustee under the Indenture. The successor Trustee will send notice of its succession to Holders.
The retiring Trustee will, upon payment of all amounts due to it under the Indenture, promptly transfer all property held by it as Trustee to the successor Trustee, which property will, for the avoidance of doubt, be subject to the lien provided for
in Section 10.06(D). 
 Section 10.08 Successor Trustee by Merger, Etc. 

If the Trustee consolidates, merges or converts into, or transfers all or substantially all of its corporate trust business to, another
corporation, then such corporation will become the successor Trustee without any further act. 
 Section 10.09. Eligibility; Disqualification.

 There will at all times be a Trustee under the Indenture that is a corporation organized and doing business under the laws of the
United States of America or of any state thereof, that is authorized under such laws to exercise corporate trustee power, that is subject to supervision or examination by federal or state authorities and that has a combined capital and surplus of at
least $100.0 million as set forth in its most recent published annual report of condition. 
 Article 11. MISCELLANEOUS 

Section 11.01. Notices. 

Any notice or communication by the Company or the Trustee to the other will be deemed to have been duly given if in writing and delivered in
person or by first class mail (registered or certified, return receipt requested), facsimile transmission, electronic transmission or other similar means of unsecured electronic communication or overnight air courier guaranteeing next day delivery,
or to the other’s address, which initially is as follows: 

  
 46 

 If to the Company: 

Xeris Pharmaceuticals, Inc. 
 180
North LaSalle Street 
 Suite 1600 Chicago, IL 60601 

Facsimile: (312) 604-5601 

Attention: Legal Department 
 with
a copy to: 
 Goodwin Procter LLP 

100 Northern Avenue 
 Boston, MA
02210 
 Facsimile: (617) 801-8864 

Attention: Joseph Theis 
 If to
the Trustee: 
 U.S. Bank National Association 

633 West Fifth Street, 24th Floor 

Los, Angeles, CA 90071 

Attention: B. Scarbrough (Xeris Pharmaceuticals, Inc.) 

The Company or the Trustee, by notice to the other, may designate additional or different addresses (including facsimile numbers and
electronic addresses) for subsequent notices or communications. 
 All notices and communications (other than those sent to Holders) will be
deemed to have been duly given: (A) at the time delivered by hand, if personally delivered; (B) five (5) Business Days after being deposited in the mail, postage prepaid, if mailed; (C) when receipt acknowledged, if transmitted by
facsimile, electronic transmission or other similar means of unsecured electronic communication; and (D) the next Business Day after timely delivery to the courier, if sent by overnight air courier guaranteeing next day delivery; provided,
that, notices to the Trustee and the Note Agents shall be effective upon actual receipt. 
 All notices or communications required to be
made to a Holder pursuant to the Indenture must be made in writing and will be deemed to be duly sent or given in writing if mailed by first class mail, certified or registered, return receipt requested, or by overnight air courier guaranteeing next
day delivery, to its address shown on the Register; provided, however, that a notice or communication to a Holder of a Global Note may, but need not, instead be sent pursuant to the Depositary Procedures (in which case, such
notice will be deemed to be duly sent or given in writing). The failure to send a notice or communication to a Holder, or any defect in such notice or communication, will not affect its sufficiency with respect to any other Holder. 

Notwithstanding any other provision of this Indenture or any Note, where this Indenture or any Note provides for notice of any event or any
other communication (including any notice of Redemption or repurchase) to a holder of a Global Note (whether by mail or otherwise), such notice will be sufficiently given if given to the Depositary (or its designee) pursuant to the standing
instructions from the Depositary or its designee, including by electronic mail in accordance with accepted practices at the Depositary. 
 If
a notice or communication is mailed or sent in the manner provided above within the time prescribed, it will be deemed to have been duly given, whether or not the addressee receives it. 

Notwithstanding anything to the contrary in the Indenture or the Notes, (A) whenever any provision of the Indenture requires a party to
send notice to another party, no such notice need be sent if the sending party and the recipient are the same Person acting in different capacities; and (B) whenever any provision of the Indenture requires a party to send notice to more than
one receiving party, and each receiving party is the same Person acting in different capacities, then only one such notice need be sent to such Person. 

Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 

Upon any request or application by the Company to the Trustee to take any action under the Indenture (other than the initial authentication of
Notes under the Indenture), the Company will furnish to the Trustee: 
 (A) an Officer’s Certificate in form reasonably
satisfactory to the Trustee that complies with Section 11.03 and states that, in the opinion of the signatory thereto, all conditions precedent and covenants, if any, provided for in the Indenture relating to such action have been
satisfied; and 

  
 47 

 (B) an Opinion of Counsel in form reasonably satisfactory to the Trustee that complies
with Section 11.03 and states that, in the opinion of such counsel, all such conditions precedent and covenants, if any, have been satisfied. 

Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 

Each Officer’s Certificate (other than an Officer’s Certificate pursuant to Section 3.03) or Opinion of Counsel with
respect to compliance with a covenant or condition provided for in the Indenture will include: 
 (a) a statement that the signatory
thereto has read such covenant or condition; 
 (b) a brief statement as to the nature and scope of the examination or investigation
upon which the statements or opinions contained therein are based; 
 (c) a statement that, in the opinion of such signatory, he, she or
it has made such examination or investigation as is necessary to enable him, her or it to express an informed opinion as to whether or not such covenant or condition has been satisfied; and 

(d) a statement as to whether, in the opinion of such signatory, such covenant or condition has been satisfied. 

Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 

The Trustee may make reasonable rules for action by or at a meeting of Holders. The Registrar or Paying Agent may make reasonable rules and set
reasonable requirements for its functions. 
 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 

No past, present or future director, officer, employee, incorporator or stockholder of the Company, as such, will have any liability for any
obligations of the Company under the Indenture or the Notes or for any claim based on, in respect of, or by reason of, such obligations or their creation. By accepting any Note, each Holder waives and releases all such liability. Such waiver and
release are part of the consideration for the issuance of the Notes. 
 Section 11.06. Governing Law; Waiver of Jury Trial. 

THIS INDENTURE AND THE NOTES, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS INDENTURE OR THE NOTES, WILL BE GOVERNED
BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. EACH OF THE COMPANY AND THE TRUSTEE IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT
OF OR RELATING TO THIS INDENTURE, THE NOTES OR THE TRANSACTIONS CONTEMPLATED BY THIS INDENTURE OR THE NOTES. 
 Section 11.07. Submission to
Jurisdiction. 
 Any legal suit, action or proceeding arising out of or based upon the Indenture or the transactions contemplated by the
Indenture may be instituted in the federal courts of the United States of America located in the City of New York or the courts of the State of New York, in each case located in the City of New York (collectively, the “Specified
Courts”), and each party irrevocably submits to the non-exclusive jurisdiction of such courts in any such suit, action or proceeding. Service of any process, summons, notice or document by mail (to
the extent allowed under any applicable statute or rule of court) to such party’s address set forth in Section 11.01 will be effective service of process for any such suit, action or proceeding brought in any such court. Each
of the Company, the Trustee and each Holder (by its acceptance of any Note) irrevocably and unconditionally waives any objection to the laying of venue of any suit, action or other proceeding in the Specified Courts and irrevocably and
unconditionally waives and agrees not to plead or claim any such suit, action or other proceeding has been brought in an inconvenient forum. 

  
 48 

 Section 11.08. No Adverse Interpretation of Other Agreements. 

Neither the Indenture nor the Notes may be used to interpret any other indenture, note, loan or debt agreement of the Company or its
Subsidiaries or of any other Person, and no such indenture, note, loan or debt agreement may be used to interpret the Indenture or the Notes. 

Section 11.09. Successors. 
 All
agreements of the Company in the Indenture and the Notes will bind its successors. All agreements of the Trustee in the Indenture will bind its successors. 

Section 11.10. Force Majeure. 
 The
Trustee and each Note Agent will not incur any liability for not performing any act or fulfilling any duty, obligation or responsibility under the Indenture or the Notes by reason of any occurrence beyond its control (including any act or provision
of any present or future law or regulation or governmental authority, act of God or war, civil unrest, local or national disturbance or disaster, epidemic, pandemic, act of terrorism or unavailability of the Federal Reserve Bank wire or facsimile or
other wire or communication facility); it being understood that the Trustee shall use reasonable efforts that are consistent with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances. 

Section 11.11. U.S.A. PATRIOT Act. 

The Company acknowledges that, in accordance with Section 326 of the U.S.A. PATRIOT Act, the Trustee, like all financial institutions, in
order to help fight the funding of terrorism and money laundering, is required to obtain, verify and record information that identifies each person or legal entity that establishes a relationship or opens an account with the Trustee. The Company
agrees to provide the Trustee with such information as it may request to enable the Trustee to comply with the U.S.A. PATRIOT Act. 
 Section 11.12.
Calculations. 
 Except as otherwise provided in the Indenture, the Company will be responsible for making all calculations called for
under the Indenture or the Notes, including determinations of the Last Reported Sale Price, accrued interest on the Notes and the Conversion Rate. 

The Company will make all calculations in good faith, and, absent manifest error, its calculations will be final and binding on all Holders.
The Company will provide a schedule of its calculations to the Trustee and the Conversion Agent, and each of the Trustee and the Conversion Agent may rely conclusively on the accuracy of the Company’s calculations without independent
verification. The Company will promptly forward a copy of each such schedule to a Holder upon its written request therefor. 
 Section 11.13.
Severability. 
 If any provision of the Indenture or the Notes is invalid, illegal or unenforceable, then the validity, legality and
enforceability of the remaining provisions of the Indenture or the Notes will not in any way be affected or impaired thereby. 
 Section 11.14.
Counterparts. 
 The parties may sign any number of copies of the Indenture. Each signed copy will be an original, and all of them
together represent the same agreement. Delivery of an executed counterpart of the Indenture by facsimile, electronically in portable document format or in any other format will be effective as delivery of a manually executed counterpart. All
notices, approvals, consents, requests and any communications hereunder must be in writing (provided that any communication sent to Trustee hereunder that is required to be signed must be in the form of a document that is signed manually
or by way of a digital signature provided by DocuSign (or such other digital signature provider as specified in writing to Trustee by the Company)), in English. The Company agrees to assume all risks arising out of the use of using digital
signatures and electronic methods to submit communications to Trustee, including without limitation the risk of Trustee acting on unauthorized instructions, and the risk of interception and misuse by third parties. 

Section 11.15. Table of Contents, Headings, Etc. 

The table of contents and the headings of the Articles and Sections of the Indenture have been inserted for convenience of reference only, are
not to be considered a part of the Indenture and will in no way modify or restrict any of the terms or provisions of the Indenture. 

  
 49 

 Section 11.16. Withholding Taxes. 

Each Holder of a Note agrees, and each beneficial owner of an interest in a Global Note, by its acquisition of such interest, is deemed to
agree, that if the Company or other applicable withholding agent pays withholding taxes or backup withholding on behalf of such Holder or beneficial owner as a result of an adjustment or the non-occurrence of
an adjustment to the Conversion Rate, then the Company or such withholding agent, as applicable, may, at its option, set off such payments against payments of cash or the delivery of other Conversion Consideration on such Note, any payments on the
Common Stock or sales proceeds received by, or other funds or assets of, such Holder or the beneficial owner of such Note. 
 Section 11.17. Trust
Indenture Act Controls. 
 If any provision of the Indenture limits, qualifies or conflicts with another provision which is required to
be included in the Indenture by the Trust Indenture Act, the required provision shall control. If any provision of the Indenture modifies or excludes any provision of the Trust Indenture Act which may be so modified or excluded, the latter provision
shall be deemed to apply to the Indenture as so modified or to be excluded, as the case may be. 
 [The Remainder of This Page
Intentionally Left Blank; Signature Page Follows] 

  
 50 

 IN WITNESS WHEREOF, the parties to this Supplemental Indenture have caused this
Supplemental Indenture to be duly executed as of the date first written above. 
  

			
	XERIS PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Paul R. Edick

	Name: Paul R. Edick
	Title: President and Chief Executive Officer
	
	U.S. Bank National Association, as Trustee
		
	By:	 	 /s/ Bradley E. Scarbrough

	Name: Bradley E. Scarbrough
	Title: Vice President

  
 B-1 

 Schedule A 

HOLDER BENEFICIAL OWNERSHIP LIMIT 

Deerfield Partners, L.P. elects that any Notes issued to it be subject to a Holder Beneficial Ownership Limit 

equal to 4.985%. 
 Deerfield Private Design Fund III,
L.P. elects that any Notes issued to it be subject to a Holder Beneficial 
 Ownership Limit equal to 4.985%. 

  
 A-1 

 EXHIBIT A 

FORM OF NOTE 
 [Insert
Global Note Legend, if applicable] 
 [Insert Restricted Note Legend, if applicable] 

[Insert Non-Affiliate Legend] 

XERIS PHARMACEUTICALS, INC. 

5.00% Convertible Senior Note due 2025 

CUSIP No.:[ ] Certificate No. [___] 
 ISIN No.: [ ] 

Xeris Pharmaceuticals, Inc., a Delaware corporation, for value received, promises to pay to [Cede & Co.], or its registered assigns,
the principal sum of [___] dollars ($[___]) [(as revised by the attached Schedule of Exchanges of Interests in the Global Note)]* on July 15, 2025 and to pay interest thereon, as
provided in the Indenture referred to below, until the principal and all accrued and unpaid interest are paid or duly provided for. 
 Interest Payment
Dates: January 15 and July 15 of each year, commencing on [date]. 
 Regular Record Dates: January 1 and July 1. 

Additional provisions of this Note are set forth on the other side of this Note. 

[The Remainder of This Page Intentionally Left Blank; Signature Page Follows] 

 

	*	 Insert bracketed language for Global Notes only. 

  
 A-2 

 IN WITNESS WHEREOF, Xeris Pharmaceuticals, Inc. has caused this instrument to be duly
executed as of the date set forth below. 
  

							
		 		 	Xeris Pharmaceuticals, Inc.
	Date: By:	 		 		 	
		 		 		 	Name:
		 		 		 	Title:

  
 A-3 

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

U.S. Bank National Association, as Trustee, certifies that this is one of the Notes referred to in the within-mentioned Indenture. 

 

			
	Date: By:	  	Authorized Signatory

  
 A-4 

 XERIS PHARMACEUTICALS, INC. 

5.00% Convertible Senior Note due 2025 

This Note is one of a duly authorized issue of notes of Xeris Pharmaceuticals, Inc., a Delaware corporation (the “Company”),
designated as its 5.00% Convertible Senior Notes due 2025 (the “Notes”), all issued or to be issued pursuant to an indenture (the “Base Indenture”), dated as of June 30, 2020, and a first
supplemental indenture (as the same may be amended from time to time, the “Supplemental Indenture,” and the Base Indenture, as amended by the Supplemental Indenture, and as the same may be further amended or supplemented from time to time
with respect to the Notes, the “Indenture”), between the Company and U.S. Bank National Association, as trustee. Capitalized terms used in this Note without definition have the respective meanings ascribed to them in the Indenture.

 The Indenture sets forth the rights and obligations of the Company, the Trustee and the Holders and the terms of the Notes.
Notwithstanding anything to the contrary in this Note, to the extent that any provision of this Note conflicts with the provisions of the Indenture, the provisions of the Indenture will control. 

1. Interest. This Note will accrue interest at a rate and in the manner set forth in Section 2.05 of the Supplemental
Indenture. Stated Interest on this Note will begin to accrue from, and including, [date]. 
 2. Maturity. This Note will
mature on July 15, 2025, unless earlier repurchased, redeemed or converted. 
 3. Method of Payment. Cash amounts due on
this Note will be paid in the manner set forth in Section 2.04 of the Supplemental Indenture. 
 4. Persons Deemed Owners.
The Holder of this Note will be treated as the owner of this Note for all purposes. 
 5. Denominations; Transfers and Exchanges.
All Notes will be in registered form, without coupons, in principal amounts equal to any Authorized Denominations. Subject to the terms of the Indenture, the Holder of this Note may transfer or exchange this Note by presenting it to the Registrar
and delivering any required documentation or other materials. 
 6. Right of Holders to Require the Company to Repurchase Notes upon
a Fundamental Change. If a Fundamental Change occurs, then each Holder will have the right to require the Company to repurchase such Holder’s Notes (or any portion thereof in an Authorized Denomination) for cash in the manner, and subject
to the terms, set forth in Section 4.02 of the Supplemental Indenture. 
 7. Right of the Company to Redeem the Notes. The
Company will have the right to redeem the Notes for cash in the manner, and subject to the terms, set forth in Section 4.03 of the Supplemental Indenture. 

8. Conversion. The Holder of this Note may convert this Note into Conversion Consideration in the manner, and subject to the terms,
set forth in Article 5 of the Supplemental Indenture. 
 9. When the Company May Merge, Etc. Article 6 of the Supplemental
Indenture places limited restrictions on the Company’s ability to be a party to a Business Combination Event. 
 10. Defaults
and Remedies. If an Event of Default occurs, then the principal amount of, and all accrued and unpaid interest on, all of the Notes then outstanding may (and, in certain circumstances, will automatically) become due and payable in the manner,
and subject to the terms, set forth in Article 7 of the Supplemental Indenture. 
 11. Amendments, Supplements and Waivers. The
Company and the Trustee may amend or supplement the Indenture or the Notes or waive compliance with any provision of the Indenture or the Notes in the manner, and subject to the terms, set forth in Article 8 of the Supplemental Indenture. 

12. No Personal Liability of Directors, Officers, Employees and Stockholders. No past, present or future director, officer,
employee, incorporator or stockholder of the Company, as such, will have any liability for any obligations of the Company under the Indenture or the Notes or for any claim based on, in respect of, or by reason of, such obligations or their creation.
By accepting any Note, each Holder waives and releases all such liability. Such waiver and release are part of the consideration for the issuance of the Notes. 

13. Authentication. No Note will be valid until it is authenticated by the Trustee. A Note will be deemed to be duly authenticated
only when an authorized signatory of the Trustee (or a duly appointed authenticating agent) manually signs the certificate of authentication of such Note. 

  
 A-5 

 14. Abbreviations. Customary abbreviations may be used in the name of a Holder
or its assignee, such as TEN COM (tenants in common), TEN ENT (tenants by the entireties), JT TEN (joint tenants with right of survivorship and not as tenants in common), CUST (custodian), and U/G/M/A (Uniform Gift to Minors Act). 

15. Governing Law. THIS NOTE, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS NOTE, WILL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 * * * 

To request a copy of the Indenture, which the Company will provide to any Holder at no charge, please send a written request to the following
address: 
 Xeris Pharmaceuticals, Inc. 

180 North LaSalle Street 
 Suite
1600 
 Chicago, IL 60601 

Facsimile: (312) 604-5601 

Attention: Legal Department 

  
 A-6 

 SCHEDULE OF EXCHANGES OF INTERESTS IN THE GLOBAL NOTE* 
 INITIAL PRINCIPAL AMOUNT OF THIS GLOBAL NOTE: $[___] 

The following exchanges, transfers or cancellations of this Global Note have been made: 

 

							
				
	 Date
	 	 Amount of Increase (Decrease) in

Principal Amount of this Global Note
	 	 Principal Amount of this Global

Note After Such Increase

(Decrease)
	  	 Signature of Authorized

Signatory of Trustee

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

				
	  
	 	  
	 	  
	  	  

  

	*	 Insert for Global Notes only. 

  
 A-7 

 CONVERSION NOTICE 

XERIS PHARMACEUTICALS, INC. 

5.00% Convertible Senior Notes due 2025 
 Subject
to the terms of the Indenture, by executing and delivering this Conversion Notice, the undersigned Holder of the Note identified below directs the Company to convert (check one): 

☐ • the entire principal amount of 
 ☐ •
$ * aggregate principal amount of 
 the Note identified by CUSIP
No. and Certificate No. . 
 The undersigned acknowledges that if the Conversion Date of a Note to be converted is after a Regular Record Date and
before the next Interest Payment Date, then such Note, when surrendered for conversion, must, in certain circumstances, be accompanied with an amount of cash equal to the interest that would have accrued on such Note to, but excluding, such Interest
Payment Date. 
  

					
	Date:
                                         
                   	 		 	  

		 		 	(Legal Name of Holder)
		 		 	 By:

		 		 	Name:
		 		 	Title:
			
		 		 	Signature Guaranteed:
		 		 	  

		 		 	Participant in a Recognized Signature
		 		 	Guarantee Medallion Program
		 		 	 By:

		 		 	Authorized Signatory

  

	*	 Must be an Authorized Denomination. 

  
 A-8 

 FUNDAMENTAL CHANGE REPURCHASE NOTICE 

XERIS PHARMACEUTICALS, INC. 

5.00% Convertible Senior Notes due 2025 
 Subject
to the terms of the Indenture, by executing and delivering this Fundamental Change Repurchase Notice, the undersigned Holder of the Note identified below is exercising its Fundamental Change Repurchase Right with respect to (check one): 

☐ • the entire principal amount of 
 ☐ •
$ * aggregate principal amount of 

the Note identified by CUSIP No. and Certificate No. . 

The undersigned acknowledges that this Note, duly endorsed for transfer, must be delivered to the Paying Agent before the Fundamental Change Repurchase Price
will be paid. 
  

					
	Date:
                                         
               	 		 	  

		 		 	(Legal Name of Holder)
		 		 	 By:

		 		 	Name:
		 		 	Title:
			
		 		 	Signature Guaranteed:
			
		 		 	  

		 		 	Participant in a Recognized Signature
		 		 	Guarantee Medallion Program
		 		 	 By:

		 		 	Authorized Signatory

  

	*	 Must be an Authorized Denomination. 

  
 A-9 

 ASSIGNMENT FORM 

XERIS PHARMACEUTICAL 
 5.00%
Convertible Senior Notes due 2025 
 Subject to the terms of the Indenture, the undersigned Holder of the within Note assigns to: 

 

			
		
	Name:	  	  

		
	Address:	  	  

		
		  	  

		
		  	  

		
		  	  

		
	Social security or tax identification number:	  	  

 the within Note and all rights thereunder irrevocably appoints: 

as agent to transfer the within Note on the books of the Company. The agent may substitute another to act for him/her. 

 

					
	Date:
                                         
           	 		 	  

		 		 	(Legal Name of Holder)
		 		 	 By:

		 		 	Name:
		 		 	Title:
			
		 		 	Signature Guaranteed:
			
		 		 	  

		 		 	Participant in a Recognized Signature
		 		 	Guarantee Medallion Program
		 		 	 By:

		 		 	Authorized Signatory

  
 A-10 

 EXHIBIT B 

FORM OF GLOBAL NOTE LEGEND 
 THIS IS A
GLOBAL NOTE WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITARY OR A NOMINEE OF THE DEPOSITARY, WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE AND ANY AGENT THEREOF AS THE OWNER AND HOLDER OF
THIS NOTE FOR ALL PURPOSES. 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (“DTC”) TO THE
COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT HEREON
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF,
CEDE & CO., HAS AN INTEREST HEREIN. 
 TRANSFERS OF THIS GLOBAL NOTE WILL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF DTC, OR
TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE, AND TRANSFERS OF PORTIONS OF THIS GLOBAL NOTE WILL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN ARTICLE 2 OF THE INDENTURE HEREINAFTER REFERRED TO. 

 

  
 B-1EX-4.3

 Exhibit 4.3 

Execution Version 
 SECOND
SUPPLEMENTAL INDENTURE 
 This SECOND SUPPLEMENTAL INDENTURE, dated as of October 5, 2021 (the “Second Supplemental
Indenture”), is entered into among Xeris Pharmaceuticals, Inc., a Delaware corporation (the “Company”), Xeris Biopharma Holdings, Inc., a Delaware corporation (“Parent”), and U.S. Bank National Association,
as trustee (the “Trustee”). 
 WHEREAS, the Company has heretofore executed and delivered to the Trustee an indenture,
dated as of June 30, 2020 (the “Base Indenture”), between the Company and the Trustee, and a First Supplemental Indenture, dated as of June 30, 2020, between the Company and the Trustee (the “First Supplemental
Indenture”; the Base Indenture as supplemented by the First Supplemental Indenture, the “Indenture”), providing for the issuance of the 5.00% Convertible Senior Notes due 2025 (the “Notes”); 

WHEREAS, on May 24, 2020, the Company entered into a Transaction Agreement (the “Transaction Agreement”) with Parent,
the Company, Strongbridge Biopharma plc, a public limited company incorporated in Ireland with registered number 562659 having its registered office at Suite 206, Fitzwilliam Hall, Fitzwilliam Place, Dublin 2, Ireland, and Wells MergerSub, Inc., a
Delaware corporation and a direct wholly-owned subsidiary of Parent (“Merger Sub”);
 WHEREAS, pursuant to the Transaction
Agreement, and subject to the terms and conditions thereof, Merger Sub will merge with and into the Company, with the Company continuing as the surviving corporation and a direct wholly-owned subsidiary of Parent (the “Merger”);

 WHEREAS, pursuant to the Transaction Agreement, at the effective time of the Merger (the “Effective Time”), each share
of common stock, $0.0001 par value per share, of the Company (the “Common Stock”) issued and outstanding immediately prior to the Effective Time (other than any shares held by the Company) will be assumed by Parent, cancelled and
automatically converted into and become the right to receive one fully paid and nonassessable share of Parent’s common stock, par value $0.0001 per share (“Parent Common Stock”), and cash in lieu of fractional entitlements as
set forth in the Transaction Agreement; 
 WHEREAS, the Merger does not constitute a Fundamental Change or a Make-Whole Fundamental Change;

 WHEREAS, the Merger constitutes a Common Stock Change Event; 

WHEREAS, Section 5.08 of the First Supplemental Indenture provides, among other things, that from and after the effective time of a
Common Stock Change Event (i) the consideration due upon conversion of any Note will be determined in the same manner as if each reference to any number of shares of Company Common Stock in the provisions described in Article 5 of the First
Supplemental Indenture (or in any related definitions) were instead a reference to the same number of Reference Property Units, and (ii) in certain circumstances, a supplemental indenture pursuant to Section 5.08 of the First Supplemental
Indenture shall be executed by an entity whose securities compose the Reference Property and shall contain such additional provisions to protect the interests of the Holders as the Company shall in good faith reasonably consider necessary in
accordance with the Indenture; 
 WHEREAS, pursuant to Section 5.08 of the First Supplemental Indenture, at or before the effective
time of a Common Stock Change Event, the Company and Parent are required to execute and deliver to the Trustee a supplemental indenture that will (i) provide for subsequent conversions of Notes in the manner set forth in Section 5.08 of
the First Supplemental Indenture, (ii) provide for subsequent adjustments to the Conversion Rate pursuant to Section 5.05(A) of the First Supplemental Indenture in a manner consistent with Section 5.08 of the First Supplemental
Indenture and (iii) contain such other provisions, if any, that the Company reasonably determines are appropriate to preserve the economic interests of the Holders and to give effect to the provisions of Section 5.08(A) of the First
Supplemental Indenture; 
 WHEREAS, Parent wishes to fully and unconditionally guarantee all of the obligations of the Company under the
Notes and the Indenture (the “Guarantee”); 

 WHEREAS, Section 8.01(F) of the First Supplemental Indenture provides that the Company
and the Trustee may amend or supplement the First Supplemental Indenture or the Notes without the consent of any Holder by entering into supplemental indentures pursuant to, and in accordance with, Section 5.08 of the First Supplemental
Indenture in connection with a Common Stock Change Event; and 
 WHEREAS, the Company has complied with all conditions precedent provided
for in the Indenture relating to this Second Supplemental Indenture. 
 NOW THEREFORE, in consideration of the foregoing and for other good
and valuable consideration, the receipt of which is hereby acknowledged, the parties hereto mutually covenant and agree for the equal and ratable benefit of the Holders as follows: 

ARTICLE I 
 DEFINITIONS 

Section 1.01 Definitions. All capitalized terms used but not defined in this Second Supplemental Indenture shall have the meanings
ascribed to such terms in the Indenture. 
 ARTICLE II 

MODIFICATIONS EFFECT OF MERGER 

SECTION 2.01. Conversion Right. Pursuant to Section 5.08 of the First Supplemental Indenture, as a result of the Merger: 

(a) from and after the Effective Time, (I) the Conversion Consideration due upon the conversion of any Note, and the conditions to
any such conversion, will be determined in the same manner as if each reference to any number of shares of Common Stock in Article 5 of the First Supplemental Indenture (or in any related definitions) were instead a reference to the same number of
Reference Property Units, with each such Reference Property Unit consisting of one share of Parent Common Stock; (II) for purposes of Section 4.03 of the First Supplemental Indenture, each reference to any number of shares of Common Stock
in such Section (or in any related definitions) will instead be deemed to be a reference to the same number of Reference Property Units; and (III) for purposes of the definition of “Fundamental Change” and “Make-Whole Fundamental
Change,” the terms “Common Stock” and “common equity” will be deemed to mean the Parent Common Stock; 
 (b) the
definition of “Common Stock” means Parent Common Stock, subject to Section 5.08 of the First Supplemental Indenture, as supplemented by this Second Supplemental Indenture; and 

(c) the provisions of the Indenture, as modified herein, including without limitation, (i) all references and provisions respecting
the terms “Conversion Price,” “Conversion Rate,” “Last Reported Sale Price,” “Market Disruption Event,” “Trading Day” and “Scheduled Trading Day” and (ii) the provisions of
Article 5 of the First Supplemental Indenture shall continue to apply, mutatis mutandis, to the Holders’ right to convert each Note into the Reference Property. 

SECTION 2.02. Anti-Dilution Adjustments. As and to the extent required by Section 5.08(a) of the Indenture, the
Conversion Rate shall be subject to anti-dilution and other adjustments with respect to the portion of Reference Property constituting Parent Common Stock that shall be as nearly equivalent as is possible to the adjustments provided for in
Section 5.05(A) of the First Supplemental Indenture. 
 SECTION 2.03. Repurchase of Notes at Option of Holders. References
to the “Company” in the definition of “Fundamental Change” in Section 1.01 of the Indenture shall instead be references to “Parent”. Except as amended hereby, the purchase rights set forth in Section 4.02 of
the First Supplemental Indenture shall continue to apply. 
 SECTION 2.04. Parent to Provide Parent Common Stock. Parent hereby
irrevocably and unconditionally agrees to be bound by the terms of the Indenture applicable to it and to issue shares of Parent Common Stock as necessary to satisfy the Company’s obligations with respect to any Notes validly surrendered for
conversion pursuant to Article 5 of the Indenture. 

 ARTICLE III 

GUARANTEE 
 SECTION 3.01.
Guarantee. (a) Parent hereby unconditionally guarantees to each Holder of Notes and to the Trustee and its successors and assigns, (i) the full and punctual payment when due of all monetary obligations of the Company under the
Indenture and (ii) the full and punctual performance within applicable grace periods of all other obligations of the Company under the Indenture. Parent further agrees that its obligations hereunder shall be unconditional, irrespective of the
absence or existence of any action to enforce the same, the recovery of any judgment against the Company (except to the extent such judgment is paid) or any waiver or amendment of the provisions of the Indenture or the Notes to the extent that any
such action or any similar action would otherwise constitute a legal or equitable discharge or defense of Parent (except that such waiver or amendment shall be effective in accordance with its terms). 

(b) Parent further agrees that its Guarantee constitutes a guarantee of payment, performance and compliance and not merely of collection.

 (c) Parent further agrees to waive presentment to, demand of payment from and protest to the Company of its Guarantee, and also
waives diligence, notice of acceptance of its Guarantee, presentment, demand for payment, notice of protest for nonpayment, the filing of claims with a court in the event of merger or bankruptcy of the Company, any right to require a proceeding
first against the Company or any other Person, and all other defenses based on suretyship. The obligations of Parent shall not be affected by any failure or delay on the part of the Trustee to exercise any right or remedy under the Indenture or the
Notes. 
 (d) The obligation of Parent to make any payment hereunder may be satisfied by causing the Company to make such payment. If
any Holder of any Note or the Trustee is required by any court or otherwise to return to the Company or Parent or any custodian, trustee, liquidator or other similar official acting in relation to the Company or Parent any amount paid by either of
them to the Trustee or such Holder, the Guarantee, to the extent theretofore discharged, shall be reinstated in full force and effect. 

(e) Upon the satisfaction and discharge of the Indenture in accordance with Article 9 thereof, Parent will be released and relieved
of any obligations under the Guarantee. 
 ARTICLE IV 

ACCEPTANCE OF SECOND SUPPLEMENTAL INDENTURE 

SECTION 4.01. Trustee’s Acceptance. The Trustee hereby accepts this Second Supplemental Indenture and agrees to perform the
same under the terms and conditions set forth in the Indenture. 
 ARTICLE V 

MISCELLANEOUS PROVISIONS 

SECTION 5.01. Effectiveness of Second Supplemental Indenture. This Second Supplemental Indenture shall become effective as of the
Effective Time. 
 SECTION 5.02. Effect of Second Supplemental Indenture. Upon the execution and delivery of this Second
Supplemental Indenture by the Company, Parent and the Trustee, the Indenture shall be supplemented and amended in accordance herewith, and this Second Supplemental Indenture shall form a part of the Indenture for all purposes, and every Holder
heretofore or hereafter authenticated and delivered under the Indenture shall be bound hereby. All the provisions of this Second Supplemental Indenture shall thereby be deemed to be incorporated in, and a part of, the Indenture; and the Indenture,
as supplemented and amended by this Second Supplemental Indenture, shall be read, taken and construed as one and the same instrument. 

 SECTION 5.03. Indenture Remains in Full Force and Effect. This Second
Supplemental Indenture shall form a part of the Indenture for all purposes and, except as supplemented or amended hereby, all other provisions in the Indenture and the Notes, to the extent not inconsistent with the terms and provisions of this
Second Supplemental Indenture, shall remain in full force and effect and is in all respects confirmed and preserved. 
 SECTION 5.04.
Headings. The titles and headings of the articles and sections of this Second Supplemental Indenture have been inserted for convenience of reference only, are not to be considered a part hereof, and shall in no way modify or restrict any of
the terms or provisions of the Indenture. 
 SECTION 5.05. Counterparts. The parties may sign any number of copies of this
Second Supplemental Indenture. Each signed copy will be an original, and all of them together represent the same agreement. Delivery of an executed counterpart of the Second Supplemental Indenture by facsimile, electronically in portable document
format or in any other format will be effective as delivery of a manually executed counterpart. All notices, approvals, consents, requests and any communications hereunder must be in writing (provided that any communication sent to Trustee hereunder
that is required to be signed must be in the form of a document that is signed manually or by way of a digital signature provided by DocuSign (or such other digital signature provider as specified in writing to Trustee by the Company)), in English.
The Company agrees to assume all risks arising out of the use of using digital signatures and electronic methods to submit communications to Trustee, including without limitation the risk of Trustee acting on unauthorized instructions, and the risk
of interception and misuse by third parties. 
 SECTION 5.06. Governing Law. THIS SECOND SUPPLEMENTAL INDENTURE, AND ANY CLAIM,
CONTROVERSY OR DISPUTE ARISING UNDER OR RELATED TO THIS SECOND SUPPLEMENTAL INDENTURE, WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 

  
 4 

 SECTION 5.07. Severability. In the event any provision of this Second
Supplemental Indenture shall be invalid, illegal or unenforceable, then the validity, legality and enforceability of the remaining provisions of the Indenture or the Notes will not in any way be affected or impaired thereby. 

SECTION 5.08. No Personal Liability of Directors, Officers, Employees and Stockholders. No past, present or future director,
officer, employee, incorporator or stockholder of the Company or Parent, as such, will have any liability for any obligations of the Company or Parent under the Indenture or the Notes or for any claim based on, in respect of, or by reason of, such
obligations or their creation. Each Holder waives and releases all such liability. 
 SECTION 5.09 Trustee Makes No Representation.
The Trustee makes no representations as to the validity or sufficiency of this Second Supplemental Indenture. The recitals and statements contained in this Second Supplemental Indenture shall be taken as the statements of the Company and Parent, and
the Trustee assumes no responsibility for the correctness of the same. 

 IN WITNESS WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be
duly executed as of the day and year first written above. 
  

			
	XERIS BIOPHARMA HOLDINGS, INC.
		
	By:	 	 
		 	Name:
		 	Title:

  

			
	XERIS PHARMACEUTICALS, INC.
		
	By:	 	 
		 	Name:
		 	Title:

  

			
	U.S. BANK NATIONAL ASSOCIATION, as Trustee
		
	By:	 	 
		 	Name:
		 	Title:

  
 Signature Page to Second
Supplemental Indenture

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