Document:

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                                                                   Exhibit 10.12
                                ORAPHARMA, INC.

                        JOINT UNANIMOUS WRITTEN CONSENT
                  OF THE BOARD OF DIRECTORS AND STOCKHOLDERS

     The undersigned, being all of the directors and the holders of sixty-six
and two-thirds percent (66-2/3%) of the Preferred Stock, par value $.001 (voting
together as a single class), and a majority of the Common Stock, par value $.001
(the "Common Stock"), of OraPharma, Inc., a Delaware corporation (the
      ------------
"Company"), hereby consent to the taking of the following actions and the
 -------
adoption of the following resolutions without a meeting in accordance with the
procedures established by Sections 141(f) and 228 of the Delaware General
Corporation Law, and agree that they shall have the same force and effect as
though duly taken and adopted at a meeting of the Board of Directors and
stockholders of the Company duly called and legally held.

IT IS HEREBY:

     RESOLVED, that it is advisable and in the best interest of the Company that
the Company's 1996 Stock Option Plan (the "Plan") be amended; and
                                           ----

     FURTHER RESOLVED, that Section 12 of the Plan be, and hereby is, amended to
read in its entirety as follows:

     CORPORATE TRANSACTIONS.
     ----------------------

               (a)  Change of Control. For purposes hereof, a "Change of
                    -----------------
        Control" transaction shall mean any of the following:

                    (i)   any person or entity, other than a person or entity
               who is a beneficial owner of the Company's securities before the
               consummation of the transaction, becomes, after such
               consummation, the beneficial owner, directly or indirectly, of
               securities of the Company representing fifty percent (50%) or
               more of the combined voting power of the Company's then
               outstanding securities;

                    (ii)  the Company consummates a merger, consolidation or
               reorganization the result of which is that the persons or
               entities who were stockholders of the Company immediately prior
               to consummation of such transaction own less than fifty percent
               (50%) of the equity of the corporation or entity surviving or
               resulting from such transaction;

                    (iii) the sale in one or more series of transactions of all
               or substantially all of the assets of the Company; or

                    (iv)  the dissolution or liquidation of the Company.
<PAGE>

               (b)  Committee or Board Action Immediately Prior to Change of
                    --------------------------------------------------------
          Control.  Immediately prior to or simultaneously with the consummation
          -------
          of a Change of Control, the Committee or the Board of Directors of the
          Company may, in its discretion, as to outstanding options (i)
          accelerate the exercise date or dates of such options pursuant to
          Section 8(a) above; (ii) upon written notice to the holders thereof,
          provided the options have been accelerated pursuant to clause (i)
          above, terminate all such options prior to the consummation of the
          transaction unless exercised within a prescribed period; (iii) provide
          for payment of an amount equal to the excess of the fair market value,
          as determined by the Committee or Board of Directors, over the Option
          Price of such shares as of the date of the transaction, in exchange
          for the surrender of the right to exercise such options; or (iv)
          provide for the assumption of such options, or the substitution
          therefor of new options, by the successor corporation or entity;
          provided, however, that with respect to ISOs the requirements of
          --------  -------
          Sections 422 and 425 of the Code shall be met.

               (c)  Termination of Employment. If in connection with the
                    -------------------------
          consummation of a Change of Control the employment by the Company (or
          its successor) of Mark B. Carbeau, Michael D. Kishbauch, James R.
          Lawter, Jan M. Lessem, James A. Ratigan or Joseph E. Zack is
          terminated by the Company (or such successor) without Cause, the
          exercise date of all outstanding options, if any, held by such person
          as of the date of such termination shall be automatically deemed
          accelerated to the date of such termination pursuant to Section 8(a)
          above; provided, however, that with respect to ISOs the requirements
                 --------  -------
          of Sections 422 and 424 of the Code shall be met.

                    For purposes hereof, "Cause" shall mean any of the
                    following:

                    (i)   the Optionee is convicted of, pleads guilty to or
                    confesses to (y) a felony, or (z) any act of fraud,
                    misappropriation, embezzlement, dishonesty or disloyalty
                    which damages the Company (or its successor) in any material
                    respect;

                    (ii)  substantial and repeated failure by the Optionee to
                    follow the direction of the Chief Executive Officer or Board
                    of Directors of the Company (or its successor) and such
                    failure is not cured within thirty (30) days after the
                    Optionee receives notice thereof from the Company (or its
                    successor);

                    (iii) failure by the Optionee to meet reasonable performance
                    objectives; or

                    (iv)  gross negligence or willful misconduct of Optionee
                    with respect to the Company (or its successor)." and

                                      -2-
<PAGE>

     FURTHER RESOLVED, that the form, terms and provisions of the Amendment to
the Restricted Stock Purchase Agreement between the Company and each of Michael
D. Kishbauch and James R. Lawter (the "Amendments") (such Amendments to be
                                       ----------
substantially in the form of the attached), be, and the same hereby are, in all
respects authorized and approved.

     IN WITNESS WHEREOF, the undersigned have executed this Unanimous Written
Consent as of the 3rd day of September, 1999.

                         DIRECTORS:

                              /s/ Michael Kishbauch
                              ----------------------
                                  Michael Kishbauch

                              /s/ James Mauzey
                              -----------------
                                  James Mauzey

                              /s/ Christopher Moller
                              -----------------------
                                  Christopher Moller

                              /s/ Eileen M. More
                              -------------------
                                  Eileen M. More

                              /s/ Harry T. Rein
                              ------------------
                                  Harry T. Rein

                              /s/ Seth Rudnick
                              -----------------
                                  Seth Rudnick

                                      -3-
<PAGE>

                              /s/ David I. Scheer
                              -------------------
                                  David I. Scheer

                              /s/ Jesse I. Treu
                              -----------------
                                  Jesse I. Treu

                         STOCKHOLDERS:

                              SCHEER INVESTMENT HOLDINGS I,
                              L.L.C.

                              By:----------------
                                  David I. Scheer
                                  Managing Member

                              OAK INVESTMENT PARTNERS VI,
                              LIMITED PARTNERSHIP

                              By: Oak Associates VI, L.L.C.,
                                  General Partner

                              By: /s/ Eileen M. More
                                 -------------------
                                      Eileen M. More
                                      Managing Member

                              OAK VI AFFILIATES FUND,
                              LIMITED PARTNERSHIP

                              By: Oak VI Affiliates L.L.C.,
                                  General Partner

                              By: /s/ Eileen M. More
                                 -------------------
                                      Eileen M. More
                                      Managing Member

                                      -4-
<PAGE>

                              CANAAN S.B.I.C., L.P.

                              By:   Canaan S.B.I.C. Partners, L.P.,
                                    General Partner

                              By: /s/ Harry T. Rein
                                 ------------------
                                      Harry T. Rein
                                      General Partner

                              CANAAN CAPITAL LIMITED
                              PARTNERSHIP

                              By:   Canaan Capital Management, L.P.,
                                    General Partner

                              By:   Canaan Capital Partners L.P.,
                                    General Partner

                              By: /s/ Harry T. Rein
                                 ------------------
                                      Harry T. Rein
                                      General Partner

                              CANAAN CAPITAL OFFSHORE
                              LIMITED PARTNERSHIP C.V.

                              By:   Canaan Capital Management L.P.,
                                    General Partner

                              By:   Canaan Capital Partners L.P.,
                                    General Partner

                              By: /s/ Harry T. Rein
                                 ------------------
                                      Harry T. Rein
                                      General Partner

                                      -5-
<PAGE>

                              CANAAN EQUITY, L.P.

                              By:   Canaan Equity Partners LLC,
                                    Member/Manager

                              By: /s/ Harry T. Rein
                                 ------------------
                                      Harry T. Rein
                                      Member/Manager

                              FRAZIER HEALTHCARE II, L.P.

                              By:   FHM, L.L.C.,
                                    General Partner

                              By:   Frazier Management, L.L.C.,
                                    Member

                              By: /s/ Jon Gilbert
                                 ----------------
                                      Jon Gilbert
                                      Member

                              TL VENTURES III L.P.

                              By:   TL Ventures III Management L.P.,
                                    General Partner

                              By:   TL Ventures III LLC,
                                    General Partner

                              By  /s/ Christopher Moller
                                 -----------------------
                                      Christopher Moller
                                      Managing Director

                                      -6-
<PAGE>

                              TL VENTURES III OFFSHORE, L.P.

                              By:   TL Ventures III Offshore Partners L.P.,
                                    General Partner

                              By:   TL Ventures III Offshore Ltd.,
                                    General Partner

                              By: /s/ Christopher Moller
                                 -----------------------
                                      Christopher Moller

                              TL VENTURES III INTERFUND L.P.

                              By:   TL Ventures III LLC,
                                    General Partner

                              By: /s/ Christopher Moller
                                 -----------------------
                                      Christopher Moller

                              DOMAIN PARTNERS IV, L.P.

                              By:   One Palmer Square Associates IV,
                                    L.L.C., General Partner
                              By:   One Palmer Square Associates IV,
                                    L.L.C., General Partner

                              By: /s/ Jesse I. Treu
                                 ------------------
                                      Managing Member

                              DP IV ASSOCIATES, L.P.

                              By:   One Palmer Square Associates IV,
                                    L.P., General Partner

                              By:/s/  Jesse I. Treu
                                 --------------------
                                      Managing Member

                                      -7-
<PAGE>

                              BIOTECHNOLOGY INVESTMENTS
                              LIMITED

                              By: Old Court Limited

                              By: /s/  Jesse I. Treu
                                 ------------------------------
                                    Attorney-in-Fact

                              SENTRON MEDICAL, INC.

                              By: -----------------------------

                              HEALTHCAP KB

                              By: Healthcap AB, General Partner

                              By: -----------------------------
                                    Director

                              HEALTHCAP KB

                              By: Healthcap AB, General Partner

                              By: -----------------------------
                                    Director

                                      -8-
<PAGE>

                              HEALTHCAP COINVEST KB

                              By:   Healthcap AB, General Partner

                              By:________________________
                                    Director

                                    /s/ Michael Kishbauch
                                    ----------------------
                                        Michael Kishbauch

                                     /s/  James R. Lawter
                                    ---------------------
                                          James R. Lawter

                                      -9-
<PAGE>

                              Frazier & Company, Inc.

                              By: /s/ [signature illegible]
                                  --------------------------

                                  --------------------------
                                       Charles H. Blanchard

                                  /s/  Jon N. Gilbert
                                  --------------------------
                                       Jon N. Gilbert

                                  /s/  Nader J. Nain
                                  --------------------------
                                       Nader J. Nain

                                  --------------------------
                                       Glenn R. Stewart

                                  /s/  Fred E. Silverstein
                                  --------------------------
                                       Fred E. Silverstein

                              American Home Products, Inc.

                              By: /s/ [signature illegible]
                                  --------------------------

                                  /s/ Dr. Gary Jernberg
                                  --------------------------
                                      Dr. Gary Jernberg

                                  /s/ Frank R. Stanton
                                  --------------------------
                                      Frank R. Stanton

                                  /s/ James E. Mulvihill
                                  --------------------------
                                      James E. Mulvihill

                              Children's Medical Center Corporation

                              By: /s/ [signature illegible]
                                  --------------------------
                                      Assistant Treasurer

                                      -10-
<PAGE>

                              Biomorphics Group, Inc.

                              By: /s/  [signature illegible]
                                  --------------------------

                                  /s/  Michael G. Lanzilotti
                                  --------------------------
                                       Michael G. Lanzilotti

                                  /s/  Dorinda Alevritis
                                  ----------------------
                                       Dorinda Alevritis

                                      -11-Subscription Agreement
                                (Pro Forma)
                           SUBSCRIPTION AGREEMENT
                               for Units of
                    Internet Stock Market Resources, Inc.
     405 CENTRAL AVENUE * 102 LOBBY LEVEL * ST. PETERSBURG, FLORIDA  33701
     This Subscription Agreement is to purchase Units of Internet Stock
Market Resources, Inc. from Internet Stock Market Resources. Each Unit
consists of four shares of Internet Stock Market Resources' common stock, par
value $0.0001 per share, plus one share of its preferred stock; for $5.00,
each of the preferred shares can be exchanged for two shares of Internet Stock
Market Resources' common stock, as long as the exchange is made within one
year of the subscription date. The minimum subscription is 100 Units. These
Units are being offered by Internet Stock Market Resources through Internet
Stock Market Resources' prospectus dated XXXX XX, 20XX. This offering is not
valid in any jurisdiction where prohibited by law or statute.
     The undersigned hereby warrants that a copy of Internet Stock Market
Resources' prospectus dated XXXX XX, 20XX has been delivered. The undersigned
furthermore warrants that he/she/it is a resident of/incorporated in one of
the following states:
                           XX, XX, XX, XX, XX
     The undersigned hereby irrevocably subscribe(s) for the following number
of Units of Internet Stock Market Resources, Inc. upon the terms and
conditions set forth in the prospectus, receipt of which is acknowledged by
signature(s) below. Number of Units subscribed for:
         _________________X $10.00 per Unit  =  $____________________.00
         -----------------                       -----------------------
         (Number of Units)                     (Total Subscription Price)
Subscription price is payable to: "Internet Stock Market Resources, Inc."
Certificates in the name(s) written below, for the number of shares
represented by the Units written above, will be printed and sent by Internet
Stock Market Resources' stock transfer agent.

INDICATE FORM OF OWNERSHIP:
[ ]  Individual.
[ ]  Joint Tenants with Right of Survivorship.(Both names must be stated
        and signed.)
[ ]  Tenants in Common.(All names must be stated and signed.)
[ ]  Trust. Trustee signs For Benefit Of:
[ ]  Corporation.(Name of Company must be stated and signed by an
        authorized officer.)
[ ]  Partnership.(Name must be set forth and signed by an authorized
        partner.)
[ ]  Other Entity.(Name must be stated and signed properly by an authorized
        person.)

PRINT OR TYPE THE FOLLOWING INFORMATION:

(Press firmly; you are making 2 copies)
1.
  ------------------------------------------------------------------------
                                    Name

  ------------------------------------------------------------------------
                                  Address

                                   (     )     -
 -----------------, ----- --------   ---   ---   -----    ----------------
  City              State ZIP Code    Telephone Number    Social Security
                                                          Number or FEIN

x
  ---------------------------------         ----------------------, ------
  Signature                                 Date

2.
  ------------------------------------------------------------------------
                                    Name

  ------------------------------------------------------------------------
                                  Address
                                   (     )     -
  ----------------, ----- --------   ---   ---   -----    ----------------
  City              State ZIP Code    Telephone Number    Social Security
                                                          Number or FEIN

x
  ----------------------------------        ----------------------, ------
  Signature                                 Date

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