Document:

Loan and Security Agreement,dated as of April 13, 2006

 Exhibit 10.3 
 Execution 4/13/06 
 LOAN AND SECURITY AGREEMENT 
 THIS LOAN AND SECURITY AGREEMENT is made and dated as of April 13, 2006 (the “Closing Date”) and is entered into by and between TRANSORAL
PHARMACEUTICALS, INC., a Delaware corporation (hereinafter referred to as the “Borrower”), with its chief executive office and principal place of business located at 1003 West Cutting Blvd., Suite 110, Point Richmond, California 94804, and
HERCULES TECHNOLOGY GROWTH CAPITAL, INC., a Maryland corporation (“Lender”), with its principal place of business located at 525 University Avenue, Suite 700, Palo Alto, CA 94301. 
 RECITALS 
 WHEREAS, Borrower has requested Lender to make available to Borrower a loan
in an aggregate principal amount of up to Ten Million Dollars ($10,000,000) (the “Loan”); and 
 WHEREAS, Lender is willing to make
the Loan on the terms and conditions set forth in this Agreement. 
 AGREEMENT 
 NOW, THEREFORE, Borrower and Lender agree as follows: 
 SECTION 1. DEFINITIONS AND RULES OF CONSTRUCTION 
 1.1. Unless otherwise defined herein, the following capitalized terms
shall have the following meanings: 
 “Account Control Agreement(s)” means any agreement entered into by and among
the Lender, Borrower and a third party Bank or other institution (including a Securities Intermediary) in which Borrower maintains a Deposit Account or an account holding Investment Property and which is intended to perfect Lender’s security
interest in any of the Collateral. 
 “Advance” means any funds advanced under this Agreement. 
 “Advance Date” means the funding date of any Advance. 
 “Advance Request” means a request for an Advance submitted by Borrower to Lender in substantially the form of
Exhibit A. 
 “Agreement” means this Loan and Security Agreement, as the same may from time to time be
amended, modified, supplemented or restated from time to time in accordance with the terms hereof. 
 “Borrower
Products” means all products, software, service offerings, technical data or technology currently being designed, manufactured or sold by Borrower or which Borrower intends to sell, license, or distribute in the future including any products or
service offerings under development, collectively, together with all products, software, service offerings, technical data or technology that have been sold, licensed or distributed by Borrower since its incorporation. 
 “Cash” means all cash and liquid funds. 
 “Closing Date” has the meaning given to it in the preamble to this Agreement. 
 “Collateral” means the property described in Section 3. 
 “Commitment Fee” means $25,000. 
 “Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or otherwise, of that Person with respect to (i) any indebtedness, lease, dividend, letter of credit
or other obligation of another, including any such obligation directly or indirectly guaranteed, endorsed, co-made or discounted or sold with recourse by that Person, or in respect of which that Person is otherwise directly or indirectly liable;
(ii) any obligations with respect to undrawn letters of credit, corporate credit 

 
cards or merchant services issued for the account of that Person; and (iii) all obligations arising under any interest rate, currency or commodity swap
agreement, interest rate cap agreement, interest rate collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; provided, however, that the
term “Contingent Obligation” shall not include endorsements for collection or deposit in the ordinary course of business. The amount of any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount of
the primary obligation in respect of which such Contingent Obligation is made or, if not stated or determinable, the maximum reasonably anticipated liability in respect thereof as determined by such Person in good faith; provided, however, that such
amount shall not in any event exceed the maximum amount of the obligations under the guarantee or other support arrangement. 
 “Copyrights” means all copyrights, whether registered or unregistered, held pursuant to the laws of the United States, any State thereof, or of any other country. 
 “Copyright License” means any written agreement granting any right to use any Copyright or Copyright registration, now owned or
hereafter acquired by Borrower or in which Borrower now holds or hereafter acquires any interest. 
 “Deposit
Accounts” means any “deposit accounts,” as such term is defined in the UCC, and includes any checking account, savings account, or certificate of deposit. 
 “Domestic Subsidiary” means a Subsidiary organized under the laws of a state, commonwealth or other jurisdiction in the United
States. 
 “Event of Default” has the meaning given to it in Section 9. 
 “Facility Fee” means seventy-five hundredths of one percent (0.75%) of the Maximum Loan Amount, which fee is due to Lender on
the Closing Date. 
 “Financial Statements” has the meaning given to it in Section 7.1. 
 “Fully Diluted Capitalization” means, at any given time, the number of shares of Borrower’s (i) common stock issued
and outstanding, and (ii) common stock ultimately issuable upon conversion, exercise or exchange of any outstanding rights to purchase Borrower’s capital stock, including preferred stock, options, warrants, employee stock plans and
convertible debt. 
 “GAAP” means generally accepted accounting principles in the United States of America, as in
effect from time to time. 
 “Indebtedness” means (a) all indebtedness for borrowed money or the deferred
purchase price of property or services, including reimbursement and other obligations with respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or similar instruments, (c) all capital
lease obligations, and (d) all Contingent Obligations. 
 “Intellectual Property” means all Copyrights;
Trademarks; Patents; Licenses; trade secrets and inventions; Borrower’s applications therefor and reissues, extensions, or renewals thereof; and Borrower’s goodwill associated with any of the foregoing, together with Borrower’s rights
to sue for past, present and future infringement of Intellectual Property and the goodwill associated therewith. 
 “Interest Rate” means, for each Advance, the prime rate as reported in The Wall Street Journal on the Advance Date for such Advance plus 2.69%. 
 “Investment” shall mean the purchase or acquisition of any capital stock, equity interest, or any obligations or other
securities of, or any interest in, any Person, or the extension of any advance, loan, extension of credit or capital contribution to, or any other investment in, any Person. 
  

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 “Joinder Agreements” means for each Domestic Subsidiary, a completed and
executed Joinder Agreement in substantially the form attached hereto. 
 “Lender” has the meaning given to it in the
preamble to this Agreement. 
 “License” means any Copyright License, Patent License, Trademark License or other
license of rights or interests. 
 “Lien” means any mortgage, deed of trust, pledge, hypothecation, assignment for
security, security interest, encumbrance, levy, lien or charge of any kind, whether voluntarily incurred or arising by operation of law or otherwise, against any property, any conditional sale or other title retention agreement, any lease in the
nature of a security interest, and the filing of any financing statement (other than a precautionary financing statement with respect to a lease that is not in the nature of a security interest) under the UCC or comparable law of any jurisdiction.

 “Loan” has the meaning given to it in the recitals to this Agreement. 
 “Loan Documents” means this Agreement, the Notes, Account Control Agreements, Joinder Agreements, all UCC Financing Statements,
the Warrant, and any other documents executed in connection with the Secured Obligations or the transactions contemplated hereby, as the same may from time to time be amended, modified, supplemented or restated. 
 “Material Adverse Effect” means a material adverse effect upon: (i) the business, operations, properties, assets, or
condition (financial or otherwise) of Borrower; or (ii) the ability of Borrower to perform the Secured Obligations in accordance with the terms of the Loan Documents, or the ability of Lender to enforce any of its rights or remedies with
respect to the Secured Obligations or under the Loan Documents; or (iii) the Collateral or Lender’s Liens on the Collateral or the priority of such Liens. 
 “Maturity Date” means October 1, 2009. 
 “Maximum Loan Amount” means $4,000,000 before Lender has received evidence that Borrower’s insomnia compound has received
positive Phase II data, in Lender’s reasonable discretion, and $10,000,000 thereafter. 
 “Maximum Rate” shall
have the meaning assigned to such term in Section 2.5. 
 “Merger” means (i) any reorganization,
recapitalization, consolidation or merger (or similar transaction or series of related transactions) of Borrower, in which the holders of Borrower’s outstanding shares immediately before consummation of such transaction or series of related
transactions do not, immediately after consummation of such transaction or series of related transactions, retain shares representing at least fifty percent (50%) of the voting power of the surviving entity of such transaction or series of
related transactions (or the parent of such surviving entity if such surviving entity is wholly owned by such parent), in each case without regard to whether Borrower is the surviving entity; (ii) the acquisition, directly or indirectly,
beneficially or of record, of 50% of the voting capital stock of Borrower by any “person” (as such term is used in Section 13(d) and 14(d) of the Securities Exchange Act of 1934), whether through a transaction or a series of related
transactions unless holders of Borrower’s outstanding shares immediately before consummation of such transaction or series of related transactions, retain shares representing at least fifty percent (50%) of the voting power of the
Borrower; (iii) any bona-fide equity financing by Borrower of its capital stock in which the “post-money” valuation of Borrower (determined by multiplying the per share price of securities sold or issued in such transaction by the
Fully Diluted Capitalization as of the date of consummation of such transaction) is less than 40% of the Borrower’s current valuation (determined by multiplying the per share price of securities sold or issued in the most recent bona-fide
equity financing prior to the Closing Date by the Fully Diluted Capitalization as of the Closing Date); (iii); (iv) the sale, lease, license or transfer of all or substantially all of the assets of Borrower or (v) acquisition by Borrower
of all or substantially all of the capital stock or assets of another Person, provided however, that in all cases a Subsidiary may be merged into Borrower without constituting a “Merger.” 
  

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 “Next Event” means the closing of Borrower’s next round of private equity
financing which first becomes effective after the Closing Date. 
 “Notes” means the Promissory Notes in
substantially the form of Exhibit B. 
 “Patent License” means any written agreement granting any right with
respect to any invention on which a Patent is in existence or a Patent application is pending, in which agreement Borrower now holds or hereafter acquires any interest. 
 “Patents” means all letters patent of, or rights corresponding thereto, in the United States or in any other country, all
registrations and recordings thereof, and all applications for letters patent of, or rights corresponding thereto, in the United States or any other country. 
 “Permitted Indebtedness” means: (a) Indebtedness of Borrower in favor of Lender arising under this Agreement or any other
Loan Document; (b) Indebtedness existing on the Closing Date and disclosed in Schedule 1A; (c) Indebtedness secured by a lien described in clause (vi) of the defined term “Permitted Liens,” provided such Indebtedness
does not exceed the lesser of the cost or fair market value of the equipment financed with such Indebtedness; (d) Indebtedness to trade creditors incurred in the ordinary course of business, including Indebtedness incurred in the ordinary
course of business with corporate credit cards; (e) Indebtedness that also constitutes a Permitted Investment; (f) Indebtedness owing to a financial institution in connection with an accounts receivable financing facility on terms
reasonably acceptable to Lender, in any case secured only by such accounts receivable; (g) Indebtedness of holders subordinated on terms reasonably satisfactory to Lender; (h) other Indebtedness in an amount not to exceed $20,000
outstanding at any time, and (i) extensions, refinancings and renewals of any items of Permitted Indebtedness, provided that the principal amount is not increased or the terms modified to impose materially more burdensome terms upon Borrower or
its Subsidiary, as the case may be. 
 “Permitted Investment” means: (a) Investments existing on the Closing
Date disclosed in Schedule 1B; (b)(i) Marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or any State thereof maturing within one year from the date of acquisition thereof,
(ii) commercial paper maturing no more than one year from the date of creation thereof and currently having rating of at least A-2 or P-2 from either Standard & Poor’s Corporation or Moody’s Investors Service,
(iii) certificates of deposit issued by any bank with assets of at least $500,000,000 maturing no more than one year from the date of investment therein, and (iv) money market accounts, deposit accounts and investment accounts;
(c) Investments accepted in connection with Permitted Transfers; (d) Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement of delinquent
obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s business; (e) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and
suppliers who are not affiliates, in the ordinary course of business, provided that this subparagraph (f) shall not apply to Investments of Borrower in any Subsidiary; (f) Investments in Subsidiaries not to exceed $250,000 in the aggregate
in any fiscal year, or of Subsidiaries in Borrower; (g) Investments consisting of the endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of Borrower; (h) Investments consisting of
travel advances and employee relocation loans and other employee loans and advances in the ordinary course of business; (i) additional Investments which do not exceed $250,000 in the aggregate in any fiscal year; (j) Investments made
pursuant to Borrower’s existing investment policy which has been approved by Lender attached hereto as Exhibit H; and (k) Joint ventures or strategic alliances in the ordinary course of Borrower’s business consisting of the
nonexclusive licensing of technology, the development of technology or the providing of technical support, provided that any cash Investments by Borrower do not exceed $250,000 in the aggregate in any fiscal year. 
  

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 “Permitted Liens” means any and all of the following: (i) Liens existing
on the Closing Date disclosed in Schedule 1C; (ii) Liens for taxes, fees, assessments or other governmental charges or levies, either not delinquent or being contested in good faith by appropriate proceedings; provided, that
Borrower maintains adequate reserves therefor in accordance with GAAP; (iii) Liens securing claims or demands of materialmen, artisans, mechanics, carriers, warehousemen, landlords and other like Persons arising in the ordinary course of
Borrower’s business and imposed without action of such parties; provided, that the payment thereof is not yet required; (iv) Liens arising from judgments, decrees or attachments in circumstances which do not constitute an Event of
Default hereunder; (v) the following deposits, to the extent made in the ordinary course of business: deposits under worker’s compensation, unemployment insurance, social security and other similar laws, or to secure the performance of
bids, tenders or contracts (other than for the repayment of borrowed money) or to secure indemnity, performance or other similar bonds for the performance of bids, tenders or contracts (other than for the repayment of borrowed money) or to secure
statutory obligations (other than liens arising under ERISA or environmental liens) or surety or appeal bonds, or to secure indemnity, performance or other similar bonds; (vi) purchase money liens and liens in connection with capital leases on
Equipment which has been acquired or held by Borrower and such Liens are incurred for financing the acquisition of the Equipment, if, the liens are confined to the Equipment and proceeds of the Equipment; (vii) Liens in favor of Lender;
(viii) easements, zoning restrictions, rights-of-way and similar encumbrances on real property imposed by law or arising in the ordinary course of business that do not secure any monetary obligations and do not materially detract from the value
of the affected property or interfere with the ordinary conduct of business of Borrower or any Subsidiary; (ix) leases, subleases or licenses granted in the ordinary course of business and not interfering in any material respect with the
business of the lessor, sublessor or licensor; (x) Liens in favor of customs and revenue authorities arising as a matter of law to secure payment of customs duties in connection within the importation of goods; (xi) Liens on insurance
proceeds securing the payment of finance insurance premiums (provided that such liens extend only to such insurance proceeds and not to any other property or assets); (xii) statutory and common law rights of set-off and other similar rights as
to deposits of cash and securities in favor of banks, other depository institutions and brokerage firms; (xiii) Liens securing Indebtedness permitted under clause (g) of Permitted Indebtedness; (xiv) Liens on accounts receivable
securing Indebtedness described in clause (f) of the defined term “Permitted Indebtedness” in an aggregate amount not exceeding $150,000; and (xv) Liens incurred in connection with the extension, renewal or refinancing of the
indebtedness secured by Liens of the type described in clauses (i) through (xiv) above; provided, that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal
amount of the indebtedness being extended, renewed or refinanced (as may have been reduced by any payment thereon) does not increase. 
 “Permitted Transfers” means (i) sales of Inventory in the normal course of business, (ii) licenses and similar arrangements for the use of property in the ordinary course of business, or
(iii) dispositions of worn-out or obsolete Equipment. 
 “Person” means any individual, sole proprietorship,
partnership, joint venture, trust, unincorporated organization, association, corporation, limited liability company, institution, other entity or government. 
 “Preferred Stock” means at any given time any equity security issued by Borrower that has any rights, preferences or privileges
senior to Borrower’s common stock. 
 “Receivables” means (i) all of Borrower’s Accounts,
Instruments, Documents, Chattel Paper, Supporting Obligations, letters of credit, proceeds of any letter of credit, and Letter of Credit Rights, and (ii) all customer lists, software, and business records related thereto. 
 “Secured Obligations” means Borrower’s obligation to repay to Lender the Loan and all Advances (whether or not evidenced by
any Note), together with all principal, interest, fees, costs, professional fees and expenses, or other liabilities or obligations for monetary amounts owed by Borrower 

  

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to Lender however arising, including the indemnity and insurance obligations in Section 6 and including such amounts as may accrue or be incurred before
or after default or workout or the commencement of any liquidation, dissolution, bankruptcy, receivership or reorganization by or against Borrower, whether due or to become due, matured or unmatured, liquidated or unliquidated, contingent or
non-contingent, and all covenants and duties of any kind or nature, present or future, in each case, arising under this Agreement, the Notes, or any of the other Loan Documents (excluding the Warrant and all obligations arising thereunder), as the
same may from time to time be amended, modified, supplemented or restated, whether or not such obligations are partially or fully secured by the value of Collateral. 
 “Subsidiary” means an entity, whether corporate, partnership, limited liability company, joint venture or otherwise, in which
Borrower owns or controls 50% or more of the outstanding voting securities, including each entity listed on Schedule 1 hereto. 
 “Trademark License” means any written agreement granting any right to use any Trademark or Trademark registration, now owned or hereafter acquired by Borrower or in which Borrower now holds or hereafter
acquires any interest. 
 “Trademarks” means all trademarks (registered, common law or otherwise) and any
applications in connection therewith, including registrations, recordings and applications in the United States Patent and Trademark Office or in any similar office or agency of the United States, any State thereof or any other country or any
political subdivision thereof. 
 “UCC” means the Uniform Commercial Code as the same is, from time to time, in
effect in the State of California; provided, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection or priority of, or remedies with respect to, Lender’s Lien on any Collateral is
governed by the Uniform Commercial Code as the same is, from time to time, in effect in a jurisdiction other than the State of California, then the term “UCC” shall mean the Uniform Commercial Code as in effect, from time to time, in such
other jurisdiction solely for purposes of the provisions thereof relating to such attachment, perfection, priority or remedies and for purposes of definitions related to such provisions. Unless otherwise defined herein or in the other Loan
Documents, terms that are defined in the UCC and used herein or in the other Loan Documents shall, unless the context indicates otherwise, have the meanings given to them in the UCC. 
 “Warrant” means the warrant entered into in connection with the Loan. 
 1.2. Unless otherwise specified, all references in this Agreement or any Annex or Schedule hereto to a “Section,” “subsection,”
“Exhibit,” “Annex,” or “Schedule” shall refer to the corresponding Section, subsection, Exhibit, Annex, or Schedule in or to this Agreement. Unless otherwise specifically provided herein, any accounting term used in
this Agreement or the other Loan Documents shall have the meaning customarily given such term in accordance with GAAP, and all financial computations hereunder shall be computed in accordance with GAAP, consistently applied. 
 SECTION 2. THE LOAN 
 2.1. Advances. Subject
to the terms and conditions of this Agreement, Lender will make one or more Advances to Borrower in an aggregate amount up to $4,000,000, each Advance to be at least $1,000,000. By May 31, 2006, Borrower shall have requested $4,000,000 in
Advances. At any time after Lender has received evidence that Borrower’s insomnia compound has received positive Phase II data, in Lender’s reasonable discretion, Borrower may request additional Advances, each Advance to be at least
$1,000,000. The aggregate outstanding Advances may be up to the Maximum Loan Amount. 
 2.2. Repayment. The principal balance of each
Advance shall bear interest thereon from the Advance Date, precomputed at the Interest Rate based on a year consisting of 360 days, with interest computed daily based on the actual number of days in each month, through December 31, 2006. The
aggregate principal balance outstanding on December 31, 2006, shall thereafter bear interest at the Interest 

  

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Rate and shall be payable in 33 equal monthly installments of principal and interest beginning January 1, 2007 and continuing on the first business day
of each month thereafter. The entire principal balance and all accrued but unpaid interest hereunder, shall be due and payable on October 1, 2009. Borrower shall make all payments under this Agreement without setoff, recoupment or deduction and
regardless of any counterclaim or defense. 
 2.3. Advance Request. To obtain an Advance, Borrower shall complete, sign and deliver an
Advance Request and Note to Lender. Lender shall fund the Advance in the manner requested by the Advance Request provided that each of the conditions precedent to such Advance is satisfied as of the requested Advance Date. 
 2.4. Prepayment. Upon at least 3 business days prior written notice, which shall be irrevocable, Borrower may prepay all or any part of the
Advances in increments of at least $1,000,000 by paying the outstanding principal amount and all accrued but unpaid interest and fees, plus a prepayment premium equal to (i) 4% of the principal prepaid if paid on or before the first anniversary
hereof, (ii) 3% of the principal prepaid if paid after the first anniversary hereof but before the second anniversary hereof, and (iii) 2% of the principal prepaid if paid on or after the second anniversary hereof. Once repaid, Borrower
may not reborrow any Advances. 
 2.5. Maximum Interest. Notwithstanding any provision in this Agreement, the Notes, or any other Loan
Document, it is the parties’ intent not to contract for, charge or receive interest at a rate that is greater than the maximum rate permissible by law that a court of competent jurisdiction shall deem applicable hereto (which under the laws of
the State of California shall be deemed to be the laws relating to permissible rates of interest on commercial loans) (the “Maximum Rate”). If a court of competent jurisdiction shall finally determine that Borrower has actually paid to
Lender an amount of interest in excess of the amount that would have been payable if all of the Secured Obligations had at all times borne interest at the Maximum Rate, then such excess interest actually paid by Borrower shall be applied as follows:
first, to the payment of principal outstanding on the Notes; second, after all principal is repaid, to the payment of Lender’s accrued interest, costs, expenses, professional fees and any other Secured Obligations; and
third, after all Secured Obligations are repaid, the excess (if any) shall be refunded to Borrower. 
 2.6. Default Interest.
In the event any payment is not paid on the scheduled Payment Date, an amount equal to two percent (2%) of the past due amount shall be payable on demand. In addition, upon the occurrence and during the continuation of an Event of Default
hereunder, all Secured Obligations, including principal, interest, compounded interest, and professional fees, shall bear interest at a rate per annum equal to the rate set forth in Section 2.2 plus five percent (5%) per annum. In the
event any interest is not paid when due hereunder, delinquent interest shall be added to principal and shall bear interest on interest, compounded at the rate set forth in Section 2.2 or Section 2.6, as applicable. 
 2.7. Mandatory Prepayment. The outstanding amount of all principal and accrued interest and unpaid interest will become immediately due and
payable at Lender’s option upon a Merger, unless otherwise agreed to in writing by Lender. 
 SECTION 3. SECURITY INTEREST 
 3.1. As security for the prompt, complete and indefeasible payment when due (whether on the Payment Dates or otherwise) of all the Secured Obligations,
Borrower grants to Lender a security interest in all of Borrower’s personal property now owned or hereafter acquired, including the following: (collectively, the “Collateral”): (a) Receivables; (b) Equipment;
(c) Fixtures; (d) General Intangibles; (e) Accounts; (f) Inventory; (g) Investment Property; (h) Deposit Accounts; (i) Cash; (j) Goods and other tangible and intangible personal property of Borrower whether
now or hereafter owned or existing, leased, consigned by or to, or acquired by, Borrower and wherever located; and (k) to the extent not otherwise included, all Proceeds of each of the foregoing and all accessions to, substitutions and
replacements for, and rents, profits and products of each of the foregoing, provided that Collateral does not include (i) Intellectual Property, but 

  

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does include any proceeds arising out of the disposition of Intellectual Property other than proceeds resulting from the licensing of Intellectual Property
in the ordinary course of Borrower’s business, (ii) more than 65% of the issued and outstanding voting capital stock of any Subsidiary that is incorporated or organized in a jurisdiction other than the United States or any state or
territory thereof or the District of Columbia if to do so would cause Borrower adverse tax consequences under Internal Revenue Code Section 956 (or any successor statute) or (iii) Equipment that is subject to a Lien that is otherwise
permitted by clause (vi) of the definition of “Permitted Lien” hereunder if inclusion of such Equipment would constitute a breach by Borrower of its agreement with a third party equipment lessor or lender, provided, that upon the
release of any such Lien, such Equipment shall be deemed to be Collateral hereunder and shall be subject to the security interest granted herein. 
 SECTION 4. CONDITIONS PRECEDENT TO LOAN 
 The obligations of Lender to make the Loan hereunder are subject to the
satisfaction by Borrower of the following conditions: 
 4.1. Initial Advance. On or prior to the Closing Date, Borrower shall have
delivered to Lender the following: 
 (a) executed originals of this Agreement, the Loan Documents, a legal opinion of
Borrower’s counsel, and all other documents and instruments reasonably required by Lender to effectuate the transactions contemplated hereby or to create and perfect the Liens of Lender with respect to all Collateral, in all cases in form and
substance reasonably acceptable to Lender; 
 (b) certified copy of resolutions of Borrower’s board of directors
evidencing approval of the Loans and other transactions evidenced by the Loan Documents; 
 (c) certified copies of the
Certificate of Incorporation and the Bylaws, as amended through the Closing Date, of Borrower; 
 (d) a certificate of good
standing for Borrower from its state of incorporation and similar certificates from all other jurisdictions in which it does business and where the failure to be qualified would have a Material Adverse Effect; 
 (e) payment of the Facility Fee and reimbursement of Lender’s current expenses reimbursable pursuant to Section 11.11, which
amounts may be deducted from the initial Advance; and 
 (f) such other documents as Lender may reasonably request.

 4.2. All Advances. On each Advance Date: 
 (a) Lender shall have received (i) an Advance Request for the relevant Advance as required by Section 2.3, duly executed by
Borrower’s Chief Executive Officer or Chief Financial Officer, and (ii) any other documents Lender may reasonably request. 
 (b) The representations and warranties set forth in Section 5 of this Agreement and in the Warrant shall be true and correct in all material respects on and as of the Advance Date with the same effect as though made on and as of such
date, except to the extent such representations and warranties expressly relate to an earlier date. 
 (c) Borrower shall be
in compliance with all the terms and provisions set forth herein and in each other Loan Document on its part to be observed or performed, and at the time of and immediately after such Advance no Event of Default shall have occurred and be
continuing. 
 (d) Each Advance Request shall be deemed to constitute a representation and warranty by Borrower on the
relevant Advance Date as to the matters specified in paragraphs (b) and (c) of this Section and as to the matters set forth in the Advance Request. 
  

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 4.3. No Default. As of the Closing Date and each Advance Date, (i) no fact or condition
exists that would (or would, with the passage of time, the giving of notice, or both) constitute an Event of Default and (ii) no event that has had or could reasonably be expected to have a Material Adverse Effect has occurred and is
continuing. 
 SECTION 5. REPRESENTATIONS AND WARRANTIES OF BORROWER 
 Borrower represents, warrants and agrees that: 
 5.1. Corporate Status. Borrower is a corporation
duly organized, legally existing and in good standing under the laws of the State of Delaware, and is duly qualified as a foreign corporation in all jurisdictions in which the nature of its business or location of its properties require such
qualifications and where the failure to be qualified could reasonably be expected to have a Material Adverse Effect. Borrower’s present name, former names (if any), locations, place of formation, tax identification number, organizational
identification number and other information are correctly set forth in Exhibit C. 
 5.2. Collateral. Borrower owns all right,
title and interest in and to the Collateral, free of all Liens whatsoever, except for Permitted Liens. Borrower has the full power and authority to grant and convey to Lender a Lien in the Collateral as security for the Secured Obligations, free of
all other Liens other than Permitted Liens. 
 5.3. Consents. Borrower’s execution, delivery and performance of the Notes, this
Agreement and all other Loan Documents, (i) have been duly authorized by all necessary corporate action of Borrower, (ii) will not result in the creation or imposition of any Lien upon the Collateral, other than Permitted Liens and the
Liens created by this Agreement and the other Loan Documents, (iii) do not violate any provisions of Borrower’s Certificate of Incorporation, bylaws, or any, law, regulation, order, injunction, judgment, decree or writ to which Borrower is
subject and (iv) except as described on Schedule 5.3, do not violate any contract or agreement or require the consent or approval of any other Person. The individual or individuals executing the Loan Documents are duly authorized to do
so. 
 5.4. Material Adverse Effect. As of the Closing Date, and after the Closing Date except as described in a written notice to
Lender, no event that has had or could reasonably be expected to have a Material Adverse Effect has occurred and is continuing. 
 5.5.
Actions Before Governmental Authorities. Except as described on Schedule 5.5, there are no actions, suits or proceedings at law or in equity or by or before any governmental authority now pending or, to the knowledge of Borrower,
threatened in writing against or affecting Borrower or any business, property or rights of Borrower (i) which involve any Loan Document or (ii) as to which there is a reasonable possibility of an adverse determination and which, if
adversely determined, would reasonably be expected to, individually or in the aggregate, result in a Material Adverse Effect. 
 5.6.
Laws. Borrower is not in violation of any law, rule or regulation, or in default with respect to any judgment, writ, injunction or decree of any governmental authority, where such violation or default is reasonably expected to result in a
Material Adverse Effect. Borrower is not in default in any manner under any provision of any indenture or other agreement, contract or instrument evidencing indebtedness, or any other material agreement, contract or instrument to which it is a party
or by which it or any of its properties or assets are or may be bound and for which such default would reasonably be expected to result in a Material Adverse Effect. 
 5.7. Information Correct. No information, report, Advance Request, financial statement, exhibit or schedule furnished, by or on behalf of Borrower to Lender in connection with any Loan Document or included
therein or delivered pursuant thereto contained, contains or will contain any material misstatement of fact or omitted, omits or will omit to state any material fact necessary to make the statements therein, in the light of the circumstances under
which they were, are or will be made, not misleading (it being recognized by Lender that projections and estimates as to future events are not to be viewed as facts and that the actual results during the period or periods covered by any such
projections and estimates may differ from projected or estimated results). 
  

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 5.8. Tax Matters. Except as described on Schedule 5.8, (a) Borrower has filed all
material federal, state and local tax returns that it is required to file, (b) Borrower has duly paid or fully reserved for all taxes or installments thereof (including any interest or penalties) as and when due, which have or may become due
pursuant to such returns, and (c) Borrower has paid or fully reserved for any tax assessment received by Borrower for the three (3) years preceding the Closing Date, if any (including any taxes being contested in good faith and by
appropriate proceedings). 
 5.9. Intellectual Property Claims. Borrower is the sole owner of, or otherwise has the right to use, the
Intellectual Property. Except as described on Schedule 5.9, to Borrower’s knowledge after due inquiry, each of the material Copyrights, Trademarks and Patents is valid and enforceable, and no part of the Intellectual Property that is
owned by Borrower has been judged invalid or unenforceable, in whole or in part, and no claim has been made to Borrower that any part of the Intellectual Property violates the rights of any third party except to the extent such claim would not
reasonably be expected to cause a Material Adverse Effect. Exhibit D is a true, correct and complete list of each of Borrower’s Patents, registered Trademarks, registered Copyrights, and material agreements under which Borrower
licenses Intellectual Property from third parties (other than shrink-wrap software licenses and other licenses which if terminated could not reasonably be expected to result in a Material Adverse Effect), together with application or registration
numbers, as applicable, owned by Borrower or any Subsidiary. Borrower is not in material breach of, nor has Borrower failed to perform any material obligations under, any of the foregoing contracts, licenses or agreements and, to Borrower’s
knowledge, no third party to any such contract, license or agreement is in material breach thereof or has failed to perform any material obligations thereunder. 
 5.10. Intellectual Property. Except as described on Schedule 5.10, Borrower’s Intellectual Property constitutes all rights with respect to Intellectual Property used in or necessary in the operation
or conduct of Borrower’s business as currently conducted and proposed to be conducted by Borrower. Without limiting the generality of the foregoing, Borrower has the right to freely transfer, license or assign Intellectual Property without
condition, restriction or payment of any kind to any third party, and Borrower owns or has the right to use, pursuant to valid licenses, all software development tools, library functions, compilers and all other third-party software and other items
that are used in the design, development, promotion, sale, license, manufacture, import, export, use or distribution of Borrower Products. 
 5.11. Borrower Products. Except as described on Schedule 5.11, no Intellectual Property owned by Borrower or Borrower Product has been or is subject to any actual or, to the knowledge of Borrower, threatened litigation,
proceeding (including any proceeding in the United States Patent and Trademark Office or any corresponding foreign office or agency) or outstanding decree, order, judgment, settlement agreement or stipulation that restricts in any manner
Borrower’s use, transfer or licensing thereof or that may affect the validity, use or enforceability thereof. There is no decree, order, judgment, agreement, stipulation, arbitral award or other provision entered into in connection with any
litigation or proceeding that obligates Borrower to grant licenses or ownership interest in any future Intellectual Property related to the operation or conduct of the business of Borrower or Borrower Products. There is no outstanding or, to the
knowledge of Borrower, threatened, dispute or disagreement of which Borrower is aware with respect to any contract, license or agreement between Borrower and any third parry related to the Intellectual Property. Borrower has not received any written
notice or claim, or, to the knowledge of Borrower, oral notice or claim, challenging or questioning Borrower’s ownership in any Intellectual Property (or written notice of any claim challenging or questioning the ownership in any licensed
Intellectual Property of the owner thereof) or suggesting that any third party has any claim of legal or beneficial ownership with respect thereto nor, to Borrower’s knowledge, is there a reasonable basis for any such claim. Neither
Borrower’s use of its Intellectual Property nor the production and sale of Borrower Products infringes the intellectual property or other rights of others. 
  

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 5.12. Financial Accounts. As of the date hereof, Schedule 5.12 is a true, correct and
complete list of (a) all banks and other financial institutions at which Borrower or any Subsidiary maintains Deposit Accounts and (b) all institutions at which Borrower or any Subsidiary maintains an account holding Investment Property,
and such exhibit correctly identifies the name, address and telephone number of each bank or other institution, the name in which the account is held, a description of the purpose of the account, and the complete account number therefor. 

5.13. Employee Loans. Borrower has no outstanding loans to any employee, officer or director of the Borrower nor has Borrower guaranteed the
payment of any loan made to an employee, officer or director of the Borrower by a third party. 
 5.14. Capitalization. As of the date
hereof, Borrower’s capitalization is set forth on Schedule 5.14 annexed hereto. Borrower does not own any stock, partnership interest or other equity securities of any Person, except for Permitted Investments. Attached as Schedule
5.14 hereto is a true, correct and complete list of each Subsidiary, and all information set forth on Schedule 5.14 is true, correct and complete. 
 SECTION 6. INSURANCE; INDEMNIFICATION 
 6.1. Coverage. So long as there are any Secured Obligations outstanding,
Borrower shall cause to be carried and maintained commercial general liability insurance, on an occurrence form, against risks customarily insured against in Borrower’s line of business. Such risks shall include the risks of bodily injury,
including death, property damage, personal injury, advertising injury, and contractual liability per the terms of the indemnification agreement found in Section 6.4. Borrower must maintain a minimum of Two Million Dollars ($2,000,000.00) of
commercial general liability insurance for each occurrence. So long as there are any Secured Obligations outstanding, Borrower shall also cause to be carried and maintained insurance upon the Collateral, insuring against all risks of physical loss
or damage howsoever caused, in an amount not less than the full replacement cost of the Collateral. Borrower shall also carry and maintain a director and officer insurance policy in an amount not less than $500,000. All proceeds of insurance shall
be returned to Borrower to repair or replace any property subject to a casualty claim or to be utilized to obtain property useful in the business of Borrower, provided that if an Event of Default exists, then such proceeds may be retained by Lender
to be applied to the outstanding Obligations. 
 6.2. Certificates. Borrower shall deliver to Lender certificates of insurance that
evidence Borrower’s compliance with its insurance obligations in Section 6.1 and the obligations contained in this Section 6.2. Borrower’s insurance certificate shall state Lender is an additional insured for commercial general
liability, an additional insured and a loss payee for all risk property damage insurance, subject to the insurer’s approval, a loss payee for fidelity insurance, and a loss payee for property insurance and additional insured for liability
insurance for any future insurance that Borrower may acquire from such insurer. Attached to the certificates of insurance will be additional insured endorsements for liability and lender’s loss payable endorsements for all risk property damage
insurance and fidelity. All certificates of insurance will provide for a minimum of thirty (30) days advance written notice to Lender of cancellation. Any failure of Lender to scrutinize such insurance certificates for compliance is not a
waiver of any of Lender’s rights, all of which are reserved. 
 6.3. Indemnity. Borrower shall and does hereby indemnify and hold
Lender, its officers, directors, employees, agents, in-house attorneys, representatives and shareholders harmless from and against any and all claims, costs, expenses, damages and liabilities (including such claims, costs, expenses, damages and
liabilities based on liability in tort, including strict liability in tort), including reasonable attorneys’ fees and disbursements and other costs of investigation or defense (including those incurred upon any appeal), that may be instituted
or asserted against or incurred by Lender or any such Person as the result of credit having been extended, suspended or terminated under this Agreement and the other Loan Documents or the administration of such credit, or in connection with or
arising out of the transactions contemplated hereunder and thereunder, or any actions or failures to act in connection therewith, or arising out of the disposition or utilization of the Collateral, excluding in all cases claims resulting from
Lender’s gross negligence or willful 

  

 11 

 
misconduct. Borrower agrees to pay, and to save Lender harmless from, any and all liabilities with respect to, or resulting from any delay in paying, any and
all excise, sales or other similar taxes (excluding taxes imposed on or measured by the net income of Lender) that may be payable or determined to be payable with respect to any of the Collateral or this Agreement. 
 SECTION 7. COVENANTS OF BORROWER 
 Borrower agrees as
follows: 
 7.1. Financial Reports. Borrower shall furnish to Lender the Compliance Certificate in the form of Exhibit F
monthly within thirty (30) days after the end of each month and the financial statements listed hereinafter, each prepared in accordance with GAAP, except with respect to unaudited financial statements, for the absence or footnotes and subject
to year-end adjustments, consistently applied (the “Financial Statements”): 
 (a) as soon as practicable (and in
any event within thirty (30) days) after the end of each month, unaudited interim financial statements as of the end of such month (prepared on a consolidated basis), including balance sheet and related statements of income and cash flows
accompanied by a report detailing any material contingencies (including the commencement of any material litigation by or against Borrower) or any other occurrence that would reasonably be expected to have a Material Adverse Effect, all certified by
Borrower’s Chief Executive Officer or Chief Financial Officer; 
 (b) as soon as practicable (and in any event within
forty five (45) days) after the end of each calendar quarter, unaudited interim financial statements as of the end of such calendar quarter (prepared on a consolidated basis), including balance sheet and related statements of income and cash
flows accompanied by a report detailing any material contingencies (including the commencement of any material litigation by or against Borrower) or any other occurrence that would reasonably be expected to have a Material Adverse Effect, all
certified by Borrower’s Chief Executive Officer or Chief Financial Officer; 
 (c) as soon as practicable (and in any
event within one hundred eighty (180) days) after the end of each fiscal year, (i) unqualified (other than as to going concern and other similar qualifications due to cash balances) audited financial statements as of the end of such year
(prepared on a consolidated basis), including balance sheet and related statements of income and cash flows, and setting forth in comparative form the corresponding figures for the preceding fiscal year, certified by a firm of independent certified
public accountants selected by Borrower and reasonably acceptable to Lender, accompanied by any management report from such accountants; 
 (d) promptly after the sending or filing thereof, as the case may be, copies of any proxy statements, financial statements or reports that Borrower has made available to holders of its Preferred Stock and copies of
any regular, periodic and special reports or registration statements that Borrower files with the Securities and Exchange Commission or any governmental authority that may be substituted therefor, or any national securities exchange; 
 (e) at the same time, and in the same manner as it gives to its directors, copies of all board materials that Borrower provides to its
directors in connection with meetings of the Board of Directors, provided that Borrower shall not be required to provide any board materials or portions thereof if it deems in its good faith judgment, such information to be highly confidential in
nature or other similar reason; and 
 (f) budgets, operating plans and other financial information as reasonably requested by
Lender. 
  

 12 

 The executed Compliance Certificate may be sent via facsimile to Lender at (866) 468-8916 or via e-mail to
kconte@herculestech.com. All Financial Statements required to be delivered pursuant to clauses (a), (b) and (c) shall be sent via e-mail to kconte@herculestech.com provided, that if e-mail is not available or sending such Financial
Statements via e-mail is not possible, they shall be sent via facsimile to Lender at: (866) 468-8916, attention Chief Credit Officer, reference TRANSORAL PHARMACEUTICALS, INC. 
 7.2. Management Rights. Borrower shall permit any representative that Lender authorizes, including its attorneys and accountants, to inspect the
Collateral, examine and make copies and abstracts of the books of account and records of Borrower at reasonable times and upon reasonable notice during normal business hours. In addition, any such representative shall have the right to meet with
management and officers of Borrower to discuss such books of account and records. In addition, Lender shall be entitled at reasonable times and intervals to consult with and advise the management and officers of Borrower concerning significant
business issues affecting Borrower. Such consultations shall not unreasonably interfere with Borrower’s business operations. The parties intend that the rights granted Lender shall constitute “management rights” within the meaning of
29 C.F.R Section 2510.3-101(d)(3)(ii), but that any advice, recommendations or participation by Lender with respect to any business issues shall not be deemed to give Lender, nor be deemed an exercise by Lender of, control over Borrower’s
management or policies. 
 7.3. Further Assurances. Borrower shall from time to time execute, deliver and file, alone or with Lender,
any financing statements, security agreements, collateral assignments, notices, control agreements, or other documents to perfect or give the highest priority to Lender’s, subject to Permitted Liens, Lien on the Collateral, as Lender shall
reasonably request. Borrower shall from time to time procure any instruments or documents as may be requested by Lender, and take all further action that may be necessary or desirable, or that Lender may reasonably request, to perfect and protect
the Liens granted hereby and thereby. In addition, and for such purposes only, Borrower hereby authorizes Lender to execute and deliver on behalf of Borrower and to file such financing statements, collateral assignments, control agreements, and
notices without the signature of Borrower either in Lender’s name or in the name of Lender as agent and attorney-in-fact for Borrower. Borrower shall protect and defend Borrower’s title to the Collateral and Lender’s Lien thereon
against all Persons claiming any interest adverse to Borrower or Lender. 
 7.4. Compromise of Agreements. Borrower shall not, except
in accordance with industry practice and in the good faith business judgment of Borrower, (a) grant any material extension of the time of payment of any of the Receivables or General Intangibles, (b) to any material extent, compromise,
compound or settle the same for less than the full amount thereof, (c) release, wholly or partly, any Person liable for the payment thereof in excess of $50,000 in the aggregate, or (d) allow any credit or discount whatsoever thereon other
than trade discounts granted by Borrower in the ordinary course of business of Borrower. 
 7.5. Indebtedness. Borrower shall not
create, incur, assume, guarantee or be or remain liable with respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness, or prepay any Indebtedness that is subordinated to Indebtedness to Lender or take any
actions which impose on Borrower an obligation to prepay any such Indebtedness. 
 7.6. Collateral. Borrower shall at all times keep
the Collateral and all other property and assets used in Borrower’s business or in which Borrower now or hereafter holds any interest free and clear from any legal process or Liens whatsoever (except for Permitted Liens), and shall give Lender
prompt written notice of any legal process affecting the Collateral, such other property and assets, or any Liens thereon. Borrower shall cause its Subsidiaries to protect and defend such Subsidiary’s title to its assets from and against all
Persons claiming any interest adverse to such Subsidiary, and Borrower shall cause its Subsidiaries at all times to keep such Subsidiary’s property and assets free and clear from any legal process or Liens whatsoever (except for Permitted
Liens), and shall give Lender prompt written notice of any legal process affecting such Subsidiary’s assets. 
  

 13 

 7.7. Investments. Borrower shall not directly or indirectly acquire or own, or make any Investment
in or to any Person, or permit any of its Subsidiaries so to do, other than Permitted Investments. 
 7.8. Distributions. Borrower
shall not, and shall not allow any Subsidiary to, (a) repurchase or redeem any class of stock or other equity interest other than pursuant to employee, director or consultant repurchase plans or other similar agreements, provided, however, in
each case the repurchase or redemption price does not exceed the original consideration paid for such stock or equity interest, or (b) declare or pay any cash dividend or make a cash distribution on any class of stock or other equity interest,
or (c) lend money to any employee, officer or director or guarantee the payment of any such loan granted by a third party in excess of $100,000 in the aggregate for all of the foregoing or (d) waive, release or forgive any indebtedness
owed by any employee, officer or director in excess of $100,000 in the aggregate. 
 7.9. Transfers. Except for Permitted Transfers,
Borrower shall not voluntarily or involuntarily transfer, sell, lease, license, lend or in any other manner convey any equitable, beneficial or legal interest in any material portion of their assets. 
 7.10. Taxes. Borrower and its Subsidiaries shall pay when due all taxes, fees or other charges of any nature whatsoever (together with any related
interest or penalties) now or hereafter imposed or assessed against Borrower, Lender or the Collateral or upon Borrower’s ownership, possession, use, operation or disposition thereof or upon Borrower’s rents, receipts or earnings arising
therefrom, except to the extent a failure to make such payments would not reasonably be expected to result in a Material Adverse Effect. Borrower shall file on or before the due date therefor all personal property tax returns in respect of the
Collateral, except to the extent a failure to make such payments would not reasonably be expected to result in a Material Adverse Effect. Notwithstanding the foregoing, Borrower may contest, in good faith and by appropriate proceedings, taxes for
which Borrower maintains adequate reserves therefor in accordance with GAAP. 
 7.11. Corporate Changes. Neither Borrower nor any
Subsidiary shall change its corporate name, legal form or jurisdiction of formation without simultaneous written notice to Lender. Neither Borrower nor any Subsidiary shall relocate its chief executive office or its principal place of business
unless: (i) it has provided prior written notice to Lender; and (ii) such relocation shall be within the continental United States. Neither Borrower nor any Subsidiary shall relocate any item of Collateral (other than (x) sales of
Inventory in the ordinary course of business, (y) relocations of equipment having an aggregate value of up to $150,000 in any fiscal year, and (z) relocations of Collateral from a location described on Exhibit C to another location
described on Exhibit C) unless (i) it has provided prompt written notice to Lender and (ii) such relocation is within the continental United States. 
 7.12. Payments. Borrower shall arrange for automatic debit and corresponding payment to Lender on each Payment Date of all periodic obligations payable to Lender under each Note or Advance. All payments to
Lender shall be wired to Lender’s bank account at the following address: 
 Hercules Technology Growth Capital, Inc. 
 C/O Union Bank of California 
 400 California Street, 2nd Floor 
 San Francisco, CA 94104 
 Acct.# 4720023798 
 ABA# 122000496

 7.13. Deposit Accounts. Neither Borrower nor any Subsidiary shall maintain any Deposit Accounts, or accounts holding Investment
Property, except with respect to which Lender has a perfected security interest in each such account. 
  

 14 

 SECTION 8. RIGHT TO PURCHASE STOCK 
 8.1. Lender or its assignee or nominee shall have the right, in its discretion, to purchase shares of Borrower’s securities having an aggregate purchase price of up to $1,000,000 in the Next Event and, subject to
the consent of the lead investor, not to be unreasonably withheld, subsequent equity offerings. Such right shall be upon the same terms and conditions afforded to other investors in the Next Event. 
 SECTION 9. EVENTS OF DEFAULT 
 The occurrence of any
one or more of the following events shall be an Event of Default: 
 9.1. Payments. Borrower fails to pay any amount due under this
Agreement, the Notes or any of the other Loan Documents within three (3) business days of the due date therefor; or 
 9.2.
Covenants. Borrower breaches or defaults in the performance of any covenant or Secured Obligation under this Agreement, the Notes, or any of the other Loan Documents, and (a) with respect to a default under any covenant under this
Agreement (other than under Sections 6, 7.5, 7.6, 7.7, 7.8 or 7.9) such default continues for more than ten (10) days after the earlier of the date on which (i) Lender has given notice of such default to Borrower and (ii) Borrower has
actual knowledge of such default or (b) with respect to a default under any of Sections 6, 7.5, 7.6, 7.7, 7.8 or 7.9, the occurrence of such default; or 
 9.3. Other Loan Documents. The occurrence of any default under any Loan Document, or any agreement between Borrower and Lender and such default continues for more than ten (10) days after the earlier of
(a) Lender has given notice of such default to Borrower, or (b) Borrower has actual knowledge of such default; or 
 9.4.
Representations. Any representation or warranty made by Borrower in any Loan Document or in the Warrant shall have been false or misleading in any material respect when made or deemed made; or 
 9.5. Insolvency. Borrower (a) shall make an assignment for the benefit of creditors; or (b) shall admit in writing its inability to pay
its debts as they become due, or its inability to pay or perform under the Loan Documents; or (c) shall file a voluntary petition in bankruptcy; or (d) shall file any petition, answer, or document seeking for itself any reorganization,
arrangement, composition, readjustment, liquidation, dissolution or similar relief under any present or future statute, law or regulation pertinent to such circumstances; or (e) shall seek or consent to or acquiesce in the appointment of any
trustee, receiver, or liquidator of Borrower or of all or any substantial part (i.e., 33-1/3% or more) of the assets or property of Borrower; or (f) shall cease operations of its business as its business has normally been conducted, or
terminate substantially all of its employees; or (g) Borrower or its directors or majority shareholders shall take any action initiating any of the foregoing actions described in clauses (a) through (f); or either (a) sixty
(60) days shall have expired after the commencement of an involuntary action against Borrower seeking reorganization, arrangement, composition, readjustment, liquidation, dissolution or similar relief under any present or future statute, law or
regulation, without such action being dismissed or all orders or proceedings thereunder affecting the operations or the business of Borrower being stayed; or (b) a stay of any such order or proceedings shall thereafter be set aside and the
action setting it aside shall not be timely appealed; or (c) Borrower shall file any answer admitting or not contesting the material allegations of a petition filed against Borrower in any such proceedings; or (d) the court in which such
proceedings are pending shall enter a decree or order granting the relief sought in any such proceedings; or sixty (60) days shall have expired after the appointment, without the consent or acquiescence of Borrower, of any trustee, receiver or
liquidator of Borrower or of all or any substantial part of the properties of Borrower without such appointment being vacated; or 
 9.6.
Attachments; Judgments. Any portion of Borrower’s assets is attached or seized, or a levy is filed against any such assets, or a judgment or judgments is/are entered for the payment of money, individually or in the aggregate, of at least
$250,000 that is not adequately covered by insurance as to which the carrier does not dispute liability, or Borrower is enjoined or in any way prevented by court order from conducting any part of its business and in each case such attachment, levy,
judgment or court order is not dismissed within ten (10) days; or 
  

 15 

 9.7. Other Obligations. The occurrence of any default under any agreement or obligation of
Borrower involving any obligation in excess of $250,000. 
 SECTION 10. REMEDIES 
 10.1. General. Upon and during the continuance of any one or more Events of Default, (i) Lender may, at its option, accelerate and demand
payment of all or any part of the Secured Obligations and declare them to be immediately due and payable (provided, that upon the occurrence of an Event of Default of the type described in Section 9.6, the Notes and all of the Secured
Obligations shall automatically be accelerated and made due and payable, in each case without any further notice or act), and (ii) Lender may notify any of Borrower’s account debtors to make payment directly to Lender, compromise the
amount of any such account on Borrower’s behalf and endorse Lender’s name without recourse on any such payment for deposit directly to Lender’s account. Upon and during the continuance of an Event of Default, the unpaid principal of
and accrued interest on the Notes and Advances and all outstanding Secured Obligations shall thereafter bear interest at the Default Rate. Lender may exercise all rights and remedies with respect to the Collateral under the Loan Documents or
otherwise available to it under the UCC and other applicable law, including the right to release, hold, sell, lease, liquidate, collect, realize upon, or otherwise dispose of all or any part of the Collateral and the right to occupy, utilize,
process and commingle the Collateral. All Lender’s rights and remedies shall be cumulative and not exclusive. 
 10.2. Collection:
Foreclosure. Upon the occurrence and during the continuance of any Event of Default, Lender may, at any time or from time to time, apply, collect, liquidate, sell in one or more sales, lease or otherwise dispose of, any or all of the Collateral,
in its then condition or following any commercially reasonable preparation or processing, in such order as Lender may elect. Any such sale may be made either at public or private sale at its place of business or elsewhere. Borrower agrees that any
such public or private sale may occur upon ten (10) calendar days’ prior written notice to Borrower. Lender may require Borrower to assemble the Collateral and make it available to Lender at a place designated by Lender that is reasonably
convenient to Lender and Borrower. The proceeds of any sale, disposition or other realization upon all or any part of the Collateral shall be applied by Lender in the following order of priorities: 
 First, to Lender in an amount sufficient to pay in full Lender’s costs and professionals’ and advisors’ fees and expenses as
described in Section 11.11; 
 Second, to Lender in an amount equal to the then unpaid amount of the Secured Obligations
(including principal, interest, and the Default Rate interest), in such order and priority as Lender may choose in its sole discretion; and 
 Finally, after the full, final, and indefeasible payment in Cash of all of the Secured Obligations, to any creditor holding a junior Lien on the Collateral, or to Borrower or its representatives or as a court of competent
jurisdiction may direct. 
 Lender shall be deemed to have acted reasonably in the custody, preservation and disposition of any of the Collateral if it
complies with the obligations of a secured party under the UCC. 
 10.3. No Waiver. Lender shall be under no obligation to marshal any
of the Collateral for the benefit of Borrower or any other Person, and Borrower expressly waives all rights, if any, to require Lender to marshal any Collateral. 
 10.4. Cumulative Remedies. The rights, powers and remedies of Lender hereunder shall be in addition to all rights, powers and remedies given by statute or rule of law and are cumulative. The exercise of any one
or more of the rights, powers and remedies provided herein shall not be construed as a waiver of or election of remedies with respect to any other rights, powers and remedies of Lender. 
  

 16 

 SECTION 11. MISCELLANEOUS 
 11.1. Severability. Whenever possible, each provision of this Agreement shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement shall be
prohibited by or invalid under such law, such provision shall be ineffective only to the extent and duration of such prohibition or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Agreement.

 11.2. Notice. Except as otherwise provided herein, any notice, demand, request, consent, approval, declaration, service of process
or other communication (including the delivery of Financial Statements) that is required, contemplated, or permitted under the Loan Documents or with respect to the subject matter hereof shall be in writing, and shall be deemed to have been validly
served, given, delivered, and received upon the earlier of: (i) the first business day after transmission by facsimile or hand delivery or deposit with an overnight express service or overnight mail delivery service; or (ii) the third
calendar day after deposit in the United States mails, with proper first class postage prepaid, in each case addressed to the party to be notified as follows: 
 (a) If to Lender: 
 HERCULES TECHNOLOGY GROWTH CAPITAL, INC. 
 Legal Department 
 Attention: Chief Legal Officer and Kathy Conte 
 525 University Ave., Suite 700 
 Palo Alto, CA 94301 
 Facsimile : 650- 473-9194 
 Telephone: 650-289-3068 
 (b) If to Borrower: 
 Prior to May 19, 2006: 
 TRANSORAL PHARMACEUTICALS, INC. 
 Attention: Thomas Soloway 
 300 Tamal Plaza, Suite 220 
 Corte Madera, CA 94925 
 Facsimile: 415-927-2240 
 Telephone: 415-945-5420 
 On and after May 19, 2006: 
 TRANSORAL PHARMACEUTICALS, INC. 
 Attention: Thomas Soloway 
 1003 West Cutting Blvd., Suite 110 
 Point Richmond, CA 94301 
 or to such other address as each party may designate for itself by like notice. 
 11.3. Entire Agreement: Amendments. This Agreement, the Notes, and the other Loan Documents constitute the entire agreement and understanding of
the parties hereto in respect of the subject matter hereof and thereof, and supersede and replace in their entirety any prior proposals, term sheets, letters, negotiations or other documents or agreements, whether written or oral, with respect to
the subject matter hereof or thereof (including Lender’s proposal letter dated February 21, 2006). None of the terms of this Agreement, the Notes or any of the other Loan Documents may be amended except by an instrument executed by each of
the parties hereto. 
  

 17 

 11.4. No Strict Construction. The parties hereto have participated jointly in the negotiation and
drafting of this Agreement. In the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the parties hereto and no presumption or burden of proof shall arise favoring or
disfavoring any party by virtue of the authorship of any provisions of this Agreement. 
 11.5. No Waiver. The powers conferred upon
Lender by this Agreement are solely to protect its rights hereunder and under the other Loan Documents and its interest in the Collateral and shall not impose any duty upon Lender to exercise any such powers. No omission or delay by Lender at any
time to enforce any right or remedy reserved to it, or to require performance of any of the terms, covenants or provisions hereof by Borrower at any time designated, shall be a waiver of any such right or remedy to which Lender is entitled, nor
shall it in any way affect the right of Lender to enforce such provisions thereafter. 
 11.6. Survival. All agreements,
representations and warranties contained in this Agreement, the Notes and the other Loan Documents or in any document delivered pursuant hereto or thereto shall be for the benefit of Lender and shall survive the execution and delivery of this
Agreement and the expiration or other termination of this Agreement. 
 11.7. Successors and Assigns. The provisions of this Agreement
and the other Loan Documents shall inure to the benefit of and be binding on Borrower and its permitted assigns (if any). Borrower shall not assign its obligations under this Agreement, the Notes or any of the other Loan Documents without
Lender’s express prior written consent, and any such attempted assignment shall be void and of no effect. Lender may assign, transfer, or endorse its rights hereunder and under the other Loan Documents without prior notice to Borrower, and all
of such rights shall inure to the benefit of Lender’s successors and assigns. 
 11.8. Governing Law. This Agreement, the Notes
and the other Loan Documents have been negotiated and delivered to Lender in the State of California, and shall have been accepted by Lender in the State of California. Payment to Lender by Borrower of the Secured Obligations is due in the State of
California. This Agreement, the Notes and the other Loan Documents shall be governed by, and construed and enforced in accordance with, the laws of the State of California, excluding conflict of laws principles that would cause the application of
laws of any other jurisdiction. 
 11.9. Consent to Jurisdiction and Venue. All judicial proceedings (to the extent that the reference
requirement of Section 11.10 is not applicable) arising in or under or related to this Agreement, the Notes or any of the other Loan Documents may be brought in any state or federal court located in the State of California. By execution and
delivery of this Agreement, each party hereto generally and unconditionally: (a) consents to nonexclusive personal jurisdiction in Santa Clara County, State of California; (b) waives any objection as to jurisdiction or venue in Santa Clara
County, State of California; (c) agrees not to assert any defense based on lack of jurisdiction or venue in the aforesaid courts; and (d) irrevocably agrees to be bound by any judgment rendered thereby in connection with this Agreement,
the Notes or the other Loan Documents. Service of process on any party hereto in any action arising out of or relating to this Agreement shall be effective if given in accordance with the requirements for notice set forth in Section 11.3, and
shall be deemed effective and received as set forth in Section 11.3. Nothing herein shall affect the right to serve process in any other manner permitted by law or shall limit the right of either party to bring proceedings in the courts of any
other jurisdiction. 
 11.10. Mutual Waiver of Jury Trial / Judicial Reference. 
 (a) Because disputes arising in connection with complex financial transactions are most quickly and economically resolved by an
experienced and expert person and the parties wish applicable state and federal laws to apply (rather than arbitration rules), the parties desire that their disputes be resolved by a judge applying such applicable laws. EACH OF BORROWER AND LENDER
SPECIFICALLY WAIVES ANY RIGHT IT MAY HAVE TO TRIAL BY JURY OF ANY CAUSE OF ACTION, CLAIM, CROSS-CLAIM, COUNTERCLAIM, THIRD PARTY CLAIM OR ANY OTHER 

  

 18 

 
CLAIM (COLLECTIVELY, “CLAIMS”) ASSERTED BY BORROWER AGAINST LENDER OR ITS ASSIGNEE OR BY LENDER OR ITS ASSIGNEE AGAINST BORROWER. This waiver
extends to all such Claims, including Claims that involve Persons other than Borrower and Lender; Claims that arise out of or are in any way connected to the relationship between Borrower and Lender; and any Claims for damages, breach of contract,
tort, specific performance, or any equitable or legal relief of any kind, arising out of this Agreement, any other Loan Document. 
 (b) If the waiver of jury trial set forth in Section 11.10(a) is ineffective or unenforceable, the parties agree that all Claims shall be resolved by reference to a private judge sitting without a jury, pursuant to Code of Civil
Procedure Section 638, before a mutually acceptable referee or, if the parties cannot agree, a referee selected by the Presiding Judge of the Santa Clara County, California. Such proceeding shall be conducted in Santa Clara County, California,
with California rules of evidence and discovery applicable to such proceeding. 
 (c) In the event Claims are to be resolved
by judicial reference, either party may seek from a court identified in Section 11.10, any prejudgment order, writ or other relief and have such prejudgment order, writ or other relief enforced to the fullest extent permitted by law
notwithstanding that all Claims are otherwise subject to resolution by judicial reference. 
 11.11. Professional Fees. Borrower
promises to pay Lender’s fees and expenses necessary to finalize the loan documentation, including but not limited to reasonable attorneys fees, UCC searches, filing costs, and other miscellaneous expenses, up to $25,000. In addition, Borrower
promises to pay any and all reasonable attorneys’ and other professionals’ fees and expenses incurred by Lender after the Closing Date in connection with or related to: (a) the Loan; (b) the administration, collection, or
enforcement of the Loan; (c) the amendment or modification of the Loan Documents; (d) any waiver, consent, release, or termination under the Loan Documents; (e) the protection, preservation, sale, lease, liquidation, or disposition of
Collateral or the exercise of remedies with respect to the Collateral; (f) any legal, litigation, administrative, arbitration, or out of court proceeding in connection with or related to Borrower or the Collateral, and any appeal or review
thereof; and (g) any bankruptcy, restructuring, reorganization, assignment for the benefit of creditors, workout, foreclosure, or other action related to Borrower, the Collateral, the Loan Documents, including representing Lender in any
adversary proceeding or contested matter commenced or continued by or on behalf of Borrower’s estate, and any appeal or review thereof. 
 11.12. Confidentiality. Lender acknowledges that certain items of Collateral including, but not limited to trade secrets, source codes, customer lists and certain other items of Intellectual Property, and any Financial Statements
provided pursuant hereto, and other information provided to Lender by Borrower are confidential and proprietary information of Borrower (the “Confidential Information”). Accordingly, Lender agrees that any Confidential Information it may
obtain in the course of acquiring, administering, or perfecting Lender’s security interest in the Collateral shall not be disclosed to any other person or entity in any manner whatsoever, in whole or in part, without the prior written consent
of Borrower, except that Lender may disclose any such information: (a) to its own directors, officers, employees, accountants, counsel and other professional advisors and to its affiliates if Lender in its sole discretion determines that any
such party should have access to such information in connection with such party’s responsibilities in connection with the Loan or this Agreement and, provided that such recipient of such Confidential Information either (i) agrees to be
bound by the confidentiality provisions of this paragraph or (ii) is otherwise subject to confidentiality restrictions that reasonably protect against the disclosure of Confidential Information; (b) if such information is generally
available to the public; (c) if required or appropriate in any report, statement or testimony submitted to any governmental authority having or claiming to have jurisdiction over Lender; (d) if required or appropriate in response to any
summons or subpoena or in connection with any litigation, to the extent permitted or deemed advisable by Lender’s counsel; (e) to comply with any legal requirement or law applicable to Lender; (f) to the extent reasonably necessary in
connection with the exercise of any right or remedy under any Loan Document, including Lender’s sale, lease, or other disposition of Collateral after default; (g) to any participant or assignee of Lender or any 

  

 19 

 
prospective participant or assignee; provided, that such participant or assignee or prospective participant or assignee agrees in writing to be bound
by this Section prior to disclosure; or (h) otherwise with the prior consent of Borrower; provided, that any disclosure made in violation of this Agreement shall not affect the obligations of Borrower or any of its affiliates or any
guarantor under this Agreement or the other Loan Documents. 
 11.13. Assignment of Rights. Borrower acknowledges and understands that
Lender may sell and assign all or part of its interest hereunder and under the Note(s) and Loan Documents to any person or entity other than a direct competitor of Borrower or any Subsidiary (an “Assignee”). After such assignment the term
“Lender” as used in the Loan Documents shall mean and include such Assignee, and such Assignee shall be vested with all rights, powers and remedies of Lender hereunder with respect to the interest so assigned; but with respect to any such
interest not so transferred, Lender shall retain all rights, powers and remedies hereby given. No such assignment by Lender shall relieve Borrower of any of its obligations hereunder. Lender agrees that in the event of any transfer by it of the
Note(s), it will endorse thereon a notation as to the portion of the principal of the Note(s), which shall have been paid at the time of such transfer and as to the date to which interest shall have been last paid thereon. 
 11.14. Revival of Secured Obligations. This Agreement and the Loan Documents shall remain in full force and effect and continue to be effective if
any petition is filed by or against Borrower for liquidation or reorganization, if Borrower becomes insolvent or makes an assignment for the benefit of creditors, if a receiver or trustee is appointed for all or any significant part of
Borrower’s assets, or if any payment or transfer of Collateral is recovered from Lender. The Loan Documents and the Secured Obligations and Collateral security shall continue to be effective, or shall be revived or reinstated, as the case may
be, if at any time payment and performance of the Secured Obligations or any transfer of Collateral to Lender, or any part thereof is rescinded, avoided or avoidable, reduced in amount, or must otherwise be restored or returned by, or is recovered
from, Lender or by any obligee of the Secured Obligations, whether as a “voidable preference,” “fraudulent conveyance,” or otherwise, all as though such payment, performance, or transfer of Collateral had not been made. In the
event that any payment, or any part thereof, is rescinded, reduced, avoided, avoidable, restored, returned, or recovered, the Loan Documents and the Secured Obligations shall be deemed, without any further action or documentation, to have been
revived and reinstated except to the extent of the full, final, and indefeasible payment to Lender in Cash. 
 11.15. Counterparts.
This Agreement and any amendments, waivers, consents or supplements hereto may be executed in any number of counterparts, and by different parties hereto in separate counterparts, each of which when so delivered shall be deemed an original, but all
of which counterparts shall constitute but one and the same instrument. 
 11.16. No Third Party Beneficiaries. No provisions of the
Loan Documents are intended, nor will be interpreted, to provide or create any third-party beneficiary rights or any other rights of any kind in any person other than Lender and Borrower unless specifically provided otherwise herein, and, except as
otherwise so provided, all provisions of the Loan Documents will be personal and solely between the Lender and the Borrower. 
 11.17.
Specific Performance. The parties hereto declare that it is impossible to measure in money the damages that will accrue to Lender by reason of Borrower’s failure to perform any of the obligations under this Agreement and agree that the
terms of this Agreement shall be specifically enforceable by lender. If Lender institutes any action or proceeding to specifically enforce the provisions hereof, any Person against whom such action or proceeding is brought hereby waives the claim or
defense therein that Lender has an adequate remedy at law, and such Person shall not offer in any such action or proceeding the claim or defense that such remedy at law exists. 
 11.18. Publicity. Lender may use Borrower’s name and logo, and include a brief description of the relationship between Borrower and Lender,
in Lender’s marketing materials. 
  

 20 

 IN WITNESS WHEREOF, Borrower and Lender have duly executed and delivered this Loan and Security Agreement
as of the day and year first above written. 
  

							
	 BORROWER:
	 		 	TRANSORAL PHARMACEUTICALS, INC.
				
		 		 	Signature:	 	/s/ Glenn A. Oclassen
		 		 	Print Name:	 	Glenn A. Oclassen
		 		 	Title:	 	CEO/[Illegible]
				
	Accepted in Palo Alto, California:	 		 		 	
			
	 LENDER:
	 		 	HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
				
		 		 	Signature:	 	/s/ Scott Harvey
		 		 	Print Name:	 	Scott Harvey
		 		 	Title:	 	Chief Legal Officer

  

 21 

 Table of Exhibits and Schedules 
  

			
		
	Exhibit A:	  	Advance Request
		  	Attachment to Advance Request
		
	Exhibit B:	  	Promissory Note
		
	Exhibit C:	  	Name, Locations, and Other Information for Borrower
		
	Exhibit D:	  	Borrower’s Patents, Trademarks, Copyrights and Licenses
		
	Exhibit E:	  	Borrower’s Deposit Accounts and Investment Accounts
		
	Exhibit F:	  	Compliance Certificate
		
	Exhibit G:	  	Joinder Agreement
		
	Exhibit H:	  	(Guaranty – if needed)
		
	Schedule 1	  	Subsidiaries
	Schedule 1A	  	Existing Permitted Indebtedness
	Schedule 1B	  	Existing Permitted Investments
	Schedule 1C	  	Existing Permitted Liens
	Schedule 5.3	  	Consents, Etc.
	Schedule 5.5	  	Actions Before Governmental Authorities
	Schedule 5.8	  	Tax Matters
	Schedule 5.9	  	Intellectual Property Claims
	Schedule 5.10	  	Intellectual Property
	Schedule 5.11	  	Borrower Products
	Schedule 5.12	  	Financial Accounts
	Schedule 5.14	  	Capitalization

  

 22 

 EXHIBIT A 
 ADVANCE REQUEST 
  

					
	 To:
	  	Lender:	  	Date:
April __, 2006
		  	Hercules Technology Growth Capital, Inc.	  	
		  	525 University Avenue, Suite 700	  	
		  	Palo Alto, CA 94301	  	
		  	Facsimile: 650-473-9194	  	
		  	Attn:	  	

 TRANSORAL PHARMACEUTICALS, INC. (“Borrower”) hereby requests from Hercules Technology Growth Capital,
Inc. (“Lender”) an Advance in the amount of __________________ Dollars ($_________ .00) on _________, ____ (the “Advance Date”) pursuant to the Loan and Security Agreement between Borrower and Lender (the “Agreement”).
Capitalized words and other terms used but not otherwise defined herein are used with the same meanings as defined in the Agreement. 
 Please: 

 

									
	 (a)
	  	Issue a check payable to Borrower	  	________	  	
				
		  	     or
	  		  	
				
	 (b)
	  	Wire Funds to Borrower’s account	  	________	  	
				
		  	Bank:	  	_____________________________	  	
		  	Address:	  	_____________________________	  	
		  		  	_____________________________	  	
		  	ABA Number:	  	_____________________________	  	
		  	Account Number:	  	_____________________________	  	
		  	Account Name:	  	_____________________________	  	

 Borrower hereby represents that the conditions precedent to the Advance set forth in the Agreement
are satisfied and shall be satisfied upon the making of such Advance, including but not limited to: (i) that no Material Adverse Effect in Borrower’s business or financial condition has occurred; (ii) that the representations and
warranties set forth in the Agreement and in the Warrant are and shall be true and correct in all material respects on and as of the Advance Date with the same effect as though made on and as of such date, except to the extent such representations
and warranties expressly relate to an earlier date; (iii) that Borrower is in compliance with all the terms and provisions set forth in each Loan Document on its part to be observed or performed; and (iv) that as of the Advance Date, no
fact or condition exists that would (or would, with the passage of time, the giving of notice, or both) constitute an Event of Default under the Loan Documents. Borrower understands and acknowledges that Lender has the right to review the financial
information supporting this representation and, if Lender determines in its reasonable discretion that a Material Adverse Effect has occurred, Lender may decline to fund the requested Advance. 
 Borrower hereby represents that Borrower’s corporate status and locations have not changed since the date of the Agreement of, if the Attachment to
this Advance Request is completed, are as set forth in the Attachment to this Advance Request. 
  

 23 

 Borrower agrees to notify Lender promptly before the funding of the Loan if any of the matters which have
been represented above shall not be true and correct on the Borrowing Date and if Lender has received no such notice before the Advance Date then the statements set forth above shall be deemed to have been made and shall be deemed to be true and
correct as of the Advance Date. 
 Executed as of April 13, 2006. 
  

			
	BORROWER: TRANSORAL PHARMACEUTICALS, INC.
		
	SIGNATURE:	 	 
	TITLE:	 	Chief Executive Officer or Chief Financial Officer
	PRINT NAME:	 	 

  

 24 

 ATTACHMENT TO ADVANCE REQUEST 
 Dated:________________ 
 Borrower hereby represents and warrants to Lender that Borrower’s current
name and organizational status is as follows: 
  

			
	 Name:
	  	TransOral Pharmaceuticals, Inc.
		
	 Type of organization:
	  	Corporation
		
	 State of organization:
	  	Delaware
		
	 Organization file number:
	  	3478309

 Borrower hereby represents and warrants to Lender that the street addresses, cities, states and
postal codes of its current locations are as follows: 
 Chief Executive Office, Principal Place of Business, and Location of Collateral:

 300 Tamal Plaza, Suite 220, Corte Madera, CA 94925 through May 19, 2006. 
 Beginning May 19, 2006, its chief executive office will be located at 1003 West Cutting Blvd., Suite 110, Point Richmond, CA, 94804 
  

 25 

 Execution 4/13/06 
 TRANSORAL PHARMACUETICALS, INC. 
 LIQUIDITY FORECASTING ANALYSIS

 CURRENT PORTFOLIO 
 3/15/2006 
  

														
	 	 	 TICKER
	  	% or
HOLDINGS	 	 	 INSTRUMENT (RATING)
	  	INVESTMENT
AT COST	  	YIELD TO
MATURITY	 
		 	MMF	  	13.31	%	 	EVERGREEN INSTITUTIONAL MMF	  	$	2,447,049	  	4.44	%
		 	AIG	  	4.05	%	 	AMERICAN GENERAL FINANCE (A1/P1)	  	$	744,245	  	4.55	%
		 	USB	  	8.11	%	 	U.S. BANCORP (AA2/A+)	  	$	1,491,405	  	4.38	%
		 	SOCNAM	  	6.70	%	 	SOCIETE GENERALE (A1+/P1)	  	$	1,231,615	  	4.47	%
	(4)	 	CCCIT	  	4.06	%	 	CITIBANK CREDIT CARD ISSUANCE TRUST (AAA/AAA)	  	$	746,719	  	4.56	%
		 	BCSFUN	  	1.35	%	 	BARCLAYS US FUNDING (A1+/P1)	  	$	248,077	  	4.72	%
		 	BCSFUN	  	1.35	%	 	BARCLAYS US FUNDING (Al+/P1)	  	$	248,133	  	4.74	%
		 	C	  	8.20	%	 	CITIGROUP (AA1/AA-)	  	$	1,508,160	  	4.53	%
	(2)	 	MBNAS	  	8.20	%	 	MBNA CREDIT CARD MASTER NOTE TRUST (AAA/AAA)	  	$	1,507,734	  	4.57	%
		 	LEH	  	4.11	%	 	LEHMAN BROTHERS (A1/A+)	  	$	755,460	  	4.56	%
	(1)	 	CCCIT	  	2.72	%	 	CITIBANK CREDIT CARD ISSUANCE TRUST (AAA/AAA)	  	$	501,016	  	4.90	%
		 	BAC	  	1.37	%	 	MBNA AMERICA BANK (AA1/AA)	  	$	251,488	  	4.81	%
		 	AAB	  	8.28	%	 	ABN AMRO (A1/A+)	  	$	1,522,185	  	4.66	%
		 	STI	  	5.52	%	 	SUNTRUST BANK (A1/A)	  	$	1,015,870	  	4.63	%
	(3)	 	CHAMT	  	2.73	%	 	CHASE CREDIT CARD MASTER TRUST (AAA/AAA)	  	$	502,441	  	4.72	%
		 	BCSFUN	  	1.33	%	 	BARCLAYS US FUNDING (A1+/P1)	  	$	244,981	  	4.92	%
		 	CCE	  	4.06	%	 	COCA-COLA ENTERPRISES (A2/A)	  	$	745,890	  	4.87	%
	(5)	 	COMT	  	1.36	%	 	CAPITAL ONE MASTER TRUST (AAA/AAA)	  	$	 250,557	  	4.90	%
		 	LEH	  	5.55	%	 	LEHMAN BROTHERS (A1/A+)	  	$	1,020,620	  	4.72	%
		 	CCE	  	2.19	%	 	COCA-COLA ENTERPRISES (A2/A)	  	$	403,104	  	4.73	%
		 	AIG	  	5.46	%	 	INTERNATIONAL LEASE FINANCE (A1/AA-)	  	$	1,005,060	  	4.95	%
		 		  			 	TOTAL	  	$	18,391,808	  	0.00	%
		 		  			 		  	 	 	  	 	 

  

	(1)	Soft bullet asset backed security. Legal final 06/16/08. 

  

	(2)	Soft bullet asset backed security. Legal final 10/15/08. 

  

	(3)	Soft bullet asset backed security. Legal final 11/17/08. 

  

	(4)	Soft bullet asset backed security. Legal final 4/7/08. 

  

	(5)	Soft bullet asset backed security. Legal final 6/15/09. 

 COMPLIANCE MATRIX 
  

					
	 General Guidelines
	  	Eligible Investments	  	Eligible Features
	 Maximum Maturity of Individual Security: 18 Months
	  	Treasuries	  	Callable
			
	 Maximum Average Maturity of Portfolio: 12 Months
	  	Agencies/GSE	  	Putable
	 Liquidity Requirement: 2x expected cash flow
	  	Corporates	  	Euro/Yankee
			
	 Issuer Concentration: 10%
	  	Bank Debt	  	Floating-rate
	 (no concentration limit on Treasury or Agency/GSE securities)
	  	Munis	  	VRDN
			
		  	Repos	  	
		  	ABS/ABCP	  	
		  	ARS	  	

 EXHIBIT B 
 SECURED PROMISSORY NOTE 
  

			
	 $10,000,000
	  	Advance Date: April __, 2006
		  	Maturity Date: October 1, 2009

 FOR VALUE RECEIVED, TRANSORAL PHARMACEUTICALS, INC., a Delaware corporation, for itself and each
of its Subsidiaries (the “Borrower”) hereby promises to pay to the order of Hercules Technology Growth Capital, Inc., a Maryland corporation or the holder of this Note (the “Lender”) at 525 University Avenue, Suite 700, Palo
Alto, CA 94301 or such other place of payment as the holder of this Secured Promissory Note (this “Promissory Note”) may specify from time to time in writing, in lawful money of the United States of America, the principal amount of Ten
Million Dollars ($10,000,000) or such other principal amount as Lender has advanced to Borrower, together with interest at a rate equal to the prime rate as reported in the Wall Street Journal as of the date hereof, plus 2.69% per annum based
upon a year consisting of 360 days, with interest computed daily based on the actual number of days in each month. 
 This Promissory Note is
the Note referred to in, and is executed and delivered in connection with, that certain Loan and Security Agreement dated April 13, 2006, by and between Borrower and Lender (as the same may from time to time be amended, modified or supplemented
in accordance with its terms, the “Loan Agreement”), and is entitled to the benefit and security of the Loan Agreement and the other Loan Documents (as defined in the Loan Agreement), to which reference is made for a statement of all of
the terms and conditions thereof. All payments shall be made in accordance with the Loan Agreement. All terms defined in the Loan Agreement shall have the same definitions when used herein, unless otherwise defined herein. An Event of Default under
the Loan Agreement shall constitute a default under this Promissory Note. Reference to the Loan Agreement shall not affect or impair the absolute and unconditional obligation of the Borrowers to pay all principal and interest and premium, if any,
under this Promissory Note upon demand or as otherwise provided herein 
 Borrower waives presentment and demand for payment, notice of
dishonor, protest and notice of protest under the UCC or any applicable law. Borrower agrees to make all payments under this Promissory Note without setoff, recoupment or deduction and regardless of any counterclaim or defense. This Promissory Note
has been negotiated and delivered to Lender and is payable in the State of California. This Promissory Note shall be governed by and construed and enforced in accordance with, the laws of the State of California, excluding any conflicts of law rules
or principles that would cause the application of the laws of any other jurisdiction. 
  

									
	BORROWER FOR ITSELF AND	 		 	
	ON BEHALF OF ITS SUBSIDIARIES:	 		 	TRANSORAL PHARMACEUTICALS, INC.
					
		 		 		 	By: 	 	 
		 		 		 	Title:	 	 

  

 2. 

 EXHIBIT C 
 NAME, LOCATIONS, AND OTHER INFORMATION FOR BORROWER 
 1. Borrower represents and warrants to Lender
that Borrower’s current name and organizational status as of the Closing Date is as follows: 
  

			
	 Name:
	  	TransOral Pharmaceuticals Inc.
		
	 Type of organization:
	  	Corporation
		
	 State of organization:
	  	Delaware
		
	 Organization file number:
	  	3478309

 2. Borrower represents and warrants to Lender that for five (5) years prior to the Closing
Date, Borrower did not do business under any other name or organization or form except the following: 
  

			
	 Name:
	  	Celeres Pharmaceuticals, Inc.
	 Used during dates of:
	  	2002
	 Type of Organization:
	  	Same
	 State of organization:
	  	Delaware
	 Organization file Number:
	  	

 Borrower’s fiscal year ends on December 31 
 Borrower’s federal employer tax identification number is: 02-0559915 
 3. Borrower represents and warrants to Lender that currently its chief executive office is located at 300 Tamal Plaza, Suite 220, Corte Madera, 94925, and that beginning on May 19, 2006, its chief executive
office will be located at 1003 West Cutting Blvd., Suite 110, Point Richmond, CA, 94804 
  

 3. 

 EXHIBIT D 
 BORROWER’S PATENTS, TRADEMARKS, COPYRIGHTS AND LICENSES 
 Borrower has no issued patents. A list of patent
applications as of March 3, 2006 is attached. 
 The Company has trademarked the name “TransOral.” The Company has entered into an agreement
with Novartis Pharmaceuticals, Inc. that it will use TransOral only as a trade name and company name, and will not use or register TransOral as a trademark in connection with any product. 
 The Company has entered into a term sheet for a non-exclusive license to PharmaBurst, versions B2 and C1. This is an excipient that comprises up to 70% of our current
zolpidem tablet weight. 
 The Company is contemplating entering into a term sheet for a non-exclusive license to PharmaBurst, versions B2 and C1 for
sumatriptan. Such license will cost a minimum of $100,000. 
 The Company has entered into a supply agreement with Plantex Pharmaceuticals, Inc. to supply
zolpidem tartrate, the active ingredient in its insomnia tablet. 
 The Company is in the process of finalizing a trademark for its insomnia product. Though
the Company may be able to trademark a name, it cannot be used for marketing and sales purposes until the FDA approves such trademark, which does not occur until shortly before product launch. 
  

 4. 

 EXHIBIT E 
 BORROWER’S DEPOSIT ACCOUNTS AND INVESTMENT ACCOUNTS 
  

	1.	State Street Bank & Trust Company 

	  	Fiduciary Investor Services 

	  	225 Franklin Street 

	  	Boston, MA 02110 

  

			
	 Account Number:
	  	DE2275
		
	 Account Officer:
	  	 K. Hughes / Capital Advisors
 617.537.3085

  

	2.	Comerica Bank 

	  	Five Palo Alto Square 

	  	3000 El Camino Real 

	  	Palo Alto, CA 94306 

  

			
	 Account Number:
	  	1892563980
		
	 Account Officer:
	  	Robert Ways
		  	650.213.1705

  

 5. 

 EXHIBIT F 
 COMPLIANCE CERTIFICATE 
 Hercules Technology Growth Capital, Inc. 
 525 University Avenue, Suite 700 
 Palo Alto, CA 94301 
 Reference is made to that certain Loan and Security Agreement dated April 13, 2006 and all ancillary documents entered into in connection with such
Loan and Security Agreement all as may be amended from time to time, (hereinafter referred to collectively as the “Loan Agreement”) between Hercules Technology Growth Capital, Inc. (“Hercules”) as Lender and TransOral
Pharmaceuticals, Inc. (the “Company”) as Borrower. All capitalized terms not defined herein shall have the same meaning as defined in the Loan Agreement. 
 The undersigned is an Officer of the Company, knowledgeable of all Company financial matters, and is authorized to provided certification of information regarding the Company; hereby certifies that in accordance with
the terms and conditions of the Loan Agreement, except as disclosed in writing to Lender, the Company is in compliance for the period ending
                     of all covenants, conditions and terms and hereby reaffirms that all representations and warrants contained therein are
true and correct on and as of the date of this Compliance Certificate with the same effect as though made on and as of such date, except to the extent such representations and warranties expressly relate to an earlier date, after giving effect in
all cases to any standard(s) of materiality contained in the Loan Agreement as to such representations and warranties. Attached are the financial statements supporting the above certification. The undersigned further certifies that these are
prepared in accordance with Generally Accepted Accounting Principles (except for the absence of footnotes with respect to unaudited financial statement and subject to normal year end adjustments) and are consistent from one period to the next except
as explained below. 
  

					
	 REPORTING REQUIREMENT
	  	REQUIRED	  	CHECK IF
ATTACHED
	 Interim Financial Statements
 Interim Financial Statements
 Audited Financial Statements
	  	Monthly within 30 days
Quarterly within 45 days
FYE within 180 days	  	

  

			
	Very Truly Yours,
	
	TRANSORAL PHARMACEUTICALS, INC.
		
	By:	 	 
		
	Name:	 	 
		
	Its:	 	 

  

 6. 

 EXHIBIT G 
 FORM OF JOINDER AGREEMENT 
 JOINDER AGREEMENT 
 This Joinder Agreement (the “Joinder Agreement”) is made and dated as of
                    , 2006, and is entered into by and between
                         (“Subsidiary”), and HERCULES TECHNOLOGY GROWTH CAPITAL, INC., a Maryland corporation,
as a Lender. 
 RECITALS 
 A. Subsidiary’s Affiliate, TransOral Pharmaceuticals, Inc. (“Company”) desires to enter into that certain Loan and Security Agreement dated April 13, 2006, with Lender, as such agreement may be amended (the “Loan
Agreement”), together with the other agreements executed and delivered in connection therewith; 
 B. Subsidiary acknowledges and agrees
that it will benefit both directly and indirectly from Company’s execution of the Loan Agreement and the other agreements executed and delivered in connection therewith; 
 AGREEMENT 
 NOW THEREFORE, Subsidiary and Lender agree as follows: 

 

	1.	The recitals set forth above are incorporated into and made part of this Joinder Agreement. Capitalized terms not defined herein shall have the meaning provided in the Loan
Agreement. 

  

	2.	By signing this Joinder Agreement, Subsidiary shall be bound by the terms and conditions of the Loan Agreement the same as if it were the Borrower (as defined in the Loan Agreement)
under the Loan Agreement, mutatis mutandis, provided however, that Lender shall have no duties, responsibilities or obligations to Subsidiary arising under or related to the Loan Agreement or the other agreements executed and delivered in
connection therewith. Rather, to the extent that Lender has any duties, responsibilities or obligations arising under or related to the Loan Agreement or the other agreements executed and delivered in connection therewith, those duties,
responsibilities or obligations shall flow only to Company and not to Subsidiary or any other person or entity. By way of example (and not an exclusive list): (a) Lender’s providing notice to Company in accordance with the Loan Agreement
or as otherwise agreed between Company and Lender shall be deemed provided to Subsidiary; (b) Lender’s providing an Advance to Company shall be deemed an Advance to Subsidiary; and (c) Subsidiary shall have no right to request an
Advance or make any other demand on Lender. 

  

							
	SUBSIDIARY:	  	 	  	
				
		  	By:                                       
                     	  		  	
		  	Name:                                      
                	  		  	
		  	Title:                                      
                  	  		  	
				
		  	Address:	  		  	
				
		  	Telephone:                                      
       	  		  	
		  	Facsimile:                                      
         	  		  	
	
	HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
			
		  	By:                                       
                                         
                           	  	
		  	Name:                                      
                                         
                       	  	
		  	Title:                                      
                                         
                         	  	
				
		  	Address:	  		  	
		  	 525 University Avenue, Suite 700
 Palo Alto,
CA 94301
 Facsimile: 650-473-9194
 Telephone:
650-289-3060
	  	

  

 7. 

 EXHIBIT H 
 INVESTMENT POLICY 
  

 8. 

 ADVANCE REQUEST 
  

					
	To:	  	Lender:	  	Date: April       , 2006
		  	Hercules Technology Growth Capital, Inc.	  	
		  	525 University Avenue, Suite 700	  	
		  	Palo Alto, CA 94301	  	
		  	Facsimile: 650-473-9194	  	
		  	Attn:	  	

 TRANSORAL PHARMACEUTICALS, INC. (“Borrower”) hereby requests from Hercules Technology Growth Capital,
Inc. (“Lender”) an Advance in the amount of                      Dollars ($
                    .00) on
                    ,              (the “Advance Date”) pursuant
to the Loan and Security Agreement between Borrower and Lender (the “Agreement”). Capitalized words and other terms used but not otherwise defined herein are used with the same meanings as defined in the Agreement. 
 Please: 
  

	 	(a)	Issue a check payable to
Borrower                            __________ 

  

	 	    	                        or 

  

	 	(b)	Wire Funds to Borrower’s
account                            __________ 

  

					
	 Bank:
	  	 	  	
	 Address:
	  	 	  	
		  	 	  	
	 ABA Number:
	  	 	  	
	 Account Number:
	  	 	  	
	 Account Name:
	  	 	  	

 Borrower hereby represents that the conditions precedent to the Advance set forth in the Agreement
are satisfied and shall be satisfied upon the making of such Advance, including but not limited to: (i) that no Material Adverse Effect in Borrower’s business or financial condition has occurred; (ii) that the representations and
warranties set forth in the Agreement and in the Warrant are and shall be true and correct in all material respects on and as of the Advance Date with the same effect as though made on and as of such date, except to the extent such representations
and warranties expressly relate to an earlier date; (iii) that Borrower is in compliance with all the terms and provisions set forth in each Loan Document on its part to be observed or performed; and (iv) that as of the Advance Date, no
fact or condition exists that would (or would, with the passage of time, the giving of notice, or both) constitute an Event of Default under the Loan Documents. Borrower understands and acknowledges that Lender has the right to review the financial
information supporting this representation and, if Lender determines in its reasonable discretion that a Material Adverse Effect has occurred, Lender may decline to fund the requested Advance. 
 Borrower hereby represents that Borrower’s corporate status and locations have not changed since the date of the Agreement of, if the Attachment to
this Advance Request is completed, are as set forth in the Attachment to this Advance Request. 

 Borrower agrees to notify Lender promptly before the funding of the Loan if any of the matters which have
been represented above shall not be true and correct on the Borrowing Date and if Lender has received no such notice before the Advance Date then the statements set forth above shall be deemed to have been made and shall be deemed to be true and
correct as of the Advance Date. 
 Executed as of April 13, 2006. 
  

			
	BORROWER: TRANSORAL PHARMACEUTICALS, INC.
		
	SIGNATURE:	 	 
	TITLE:	 	Chief Executive Officer or Chief Financial Officer
	PRINT NAME:	 	 

  

 2 

 ATTACHMENT TO ADVANCE REQUEST 
 Dated:                             
 Borrower hereby represents and warrants to Lender that Borrower’s current name and organizational status is as follows: 
  

			
	Name:	  	TransOral Pharmaceuticals, Inc.
		
	Type of organization :	  	Corporation
		
	State of organization:	  	Delaware
		
	Organization file number:	  	3478309

 Borrower hereby represents and warrants to Lender that the street addresses, cities, states and postal codes of
its current locations are as follows: 
 Chief Executive Office, Principal Place of Business, and Location of Collateral: 
 300 Tamal Plaza, Suite 220, Corte Madera, CA 94925 through May 19, 2006. 
 Beginning May 19, 2006, its chief executive office will be located at 1003 West Cutting Blvd., Suite 110, Point Richmond, CA, 94804 
  

 3 

 SECURED PROMISSORY NOTE 
  

			
	 $10,000,000
	  	Advance Date: April        , 2006
		  	Maturity Date: October 1, 2009

 FOR VALUE RECEIVED, TRANSORAL PHARMACEUTICALS, INC., a Delaware corporation, for itself and each
of its Subsidiaries (the “Borrower”) hereby promises to pay to the order of Hercules Technology Growth Capital, Inc., a Maryland corporation or the holder of this Note (the “Lender”) at 525 University Avenue, Suite 700, Palo
Alto, CA 94301 or such other place of payment as the holder of this Secured Promissory Note (this “Promissory Note”) may specify from time to time in writing, in lawful money of the United States of America, the principal amount of Ten
Million Dollars ($10,000,000) or such other principal amount as Lender has advanced to Borrower, together with interest at a rate equal to the prime rate as reported in the Wall Street Journal as of the date hereof, plus 2.69% per annum based
upon a year consisting of 360 days, with interest computed daily based on the actual number of days in each month. 
 This Promissory Note is
the Note referred to in, and is executed and delivered in connection with, that certain Loan and Security Agreement dated April 13, 2006, by and between Borrower and Lender (as the same may from time to time be amended, modified or supplemented
in accordance with its terms, the “Loan Agreement”), and is entitled to the benefit and security of the Loan Agreement and the other Loan Documents (as defined in the Loan Agreement), to which reference is made for a statement of all of
the terms and conditions thereof. All payments shall be made in accordance with the Loan Agreement. All terms defined in the Loan Agreement shall have the same definitions when used herein, unless otherwise defined herein. An Event of Default under
the Loan Agreement shall constitute a default under this Promissory Note. Reference to the Loan Agreement shall not affect or impair the absolute and unconditional obligation of the Borrowers to pay all principal and interest and premium, if any,
under this Promissory Note upon demand or as otherwise provided herein 
 Borrower waives presentment and demand for payment, notice of
dishonor, protest and notice of protest under the UCC or any applicable law. Borrower agrees to make all payments under this Promissory Note without setoff, recoupment or deduction and regardless of any counterclaim or defense. This Promissory Note
has been negotiated and delivered to Lender and is payable in the State of California. This Promissory Note shall be governed by and construed and enforced in accordance with, the laws of the State of California, excluding any conflicts of law rules
or principles that would cause the application of the laws of any other jurisdiction. 
  

									
	 BORROWER FOR ITSELF AND
 ON BEHALF OF ITS
SUBSIDIARIES:
	 		 	TRANSORAL PHARMACEUTICALS, INC.
					
		 		 		 	By:	 	 
		 		 		 	Title:	 	 

  

 4.Secured Promissory Note,dated as of May 31, 2006

 Exhibit 10.4 
 SECURED PROMISSORY NOTE 
  

			
	$4,000,000.00	  	Advance Date: May 31, 2006
		  	Maturity Date: October 1, 2009

 FOR VALUE RECEIVED, TRANSORAL PHARMACEUTICALS, INC., a Delaware corporation, for itself and each
of its Subsidiaries (the “Borrower”) hereby promises to pay to the order of Hercules Technology Growth Capital, Inc., a Maryland corporation or the holder of this Note (the “Lender”) at 525 University Avenue, Suite 700, Palo
Alto, CA 94301 or such other place of payment as the holder of this Secured Promissory Note (this “Promissory Note”) may specify from time to time in writing, in lawful money of the United States of America, the principal amount of Four
Million Dollars ($4,000,000.00) or such other principal amount as Lender has advanced to Borrower, together with interest at a rate equal to the prime rate as reported in the Wall Street Journal as of the date hereof, plus 2.69% per annum based
upon a year consisting of 360 days, with interest computed daily based on the actual number of days in each month. 
 This Promissory Note is
the Note referred to in, and is executed and delivered in connection with, that certain Loan and Security Agreement dated April 21, 2006, by and between Borrower and Lender (as the same may from time to time be amended, modified or supplemented
in accordance with its terms, the “Loan Agreement”), and is entitled to the benefit and security of the Loan Agreement and the other Loan Documents (as defined in the Loan Agreement), to which reference is made for a statement of all of
the terms and conditions thereof. All payments shall be made in accordance with the Loan Agreement. All terms defined in the Loan Agreement shall have the same definitions when used herein, unless otherwise defined herein. An Event of Default under
the Loan Agreement shall constitute a default under this Promissory Note. Reference to the Loan Agreement shall not affect or impair the absolute and unconditional obligation of the Borrowers to pay all principal and interest and premium, if any,
under this Promissory Note upon demand or as otherwise provided herein 
 Borrower waives presentment and demand for payment, notice of
dishonor, protest and notice of protest under the UCC or any applicable law. Borrower agrees to make all payments under this Promissory Note without setoff, recoupment or deduction and regardless of any counterclaim or defense. This Promissory Note
has been negotiated and delivered to Lender and is payable in the State of California. This Promissory Note shall be governed by and construed and enforced in accordance with, the laws of the State of California, excluding any conflicts of law rules
or principles that would cause the application of the laws of any other jurisdiction. 
  

									
	 BORROWER FOR ITSELF AND
 ON BEHALF OF ITS
SUBSIDIARIES:
	 		 	TRANSORAL PHARMACEUTICALS, INC.
					
		 		 		 	By:	 	/s/ Illegible
		 		 		 	Title:	 	CEO/President

 TransOral Pharmaceuticals, Inc. 
 ADVANCE REQUEST 
  

							
	To:	  	Lender:	  	Date:	  	May 11, 2006
		  	Hercules Technology Growth Capital, Inc.	  		  	
		  	525 University Avenue, Suite 700	  		  	
		  	Palo Alto, CA 94301	  		  	
		  	Facsimile: 650-473-9194	  		  	

 TRANSORAL PHARMACEUTICALS, INC. (“Borrower”) hereby requests from Hercules Technology Growth Capital,
Inc. (“Lender”) an Advance in the amount of Four Million Dollars ($4,000,000.00) on May 31, 2006 (the “Advance Date”) pursuant to the Loan and Security Agreement between Borrower and Lender (the “Agreement”).
Capitalized words and other terms used but not otherwise defined herein are used with the same meanings as defined in the Agreement. 
 Please: 

 

	 	(a)	Issue a check payable to Borrower                      ̈ 

 or 
  

	 	(b)	Wire Funds to Borrower’s account                   x 

  

			
	Bank:	  	Comerica Bank
		  	333 W. Santa Clara Street
		  	San Jose, CA 95113
		
	ABA Number:	  	121137522
		
	Account Number:	  	1892563980
		
	Account Name:	  	TransOral Pharmaceuticals, Inc.

 Borrower hereby represents that the conditions precedent to the Advance set forth in the Agreement
are satisfied and shall be satisfied upon the making of such Advance, including but not limited to: (i) that no Material Adverse Effect in Borrower’s business or financial condition has occurred; (ii) that the representations and
warranties set forth in the Agreement and in the Warrant are and shall be true and correct in all material respects on and as of the Advance Date with the same effect as though made on and as of such date, except to the extent such representations
and warranties expressly relate to an earlier date; (iii) that Borrower is in compliance with all the terms and provisions set forth in each Loan Document on its part to be observed or performed; and (iv) that as of the Advance Date, no
fact or condition exists that would (or would, with the passage of time, the giving of notice, or both) constitute an Event of Default under the Loan Documents. Borrower understands and acknowledges that Lender has the right to review the financial
information supporting this representation and, if Lender determines in its reasonable discretion that a Material Adverse Effect has occurred, Lender may decline to fund the requested Advance. 
 Borrower hereby represents that Borrower’s corporate status and locations have not changed since the date of the Agreement or, if the Attachment to
this Advance Request is completed, are as set forth in the Attachment to this Advance Request. 
 300 Tamal Plaza, Suite 220 Corte Madera,
California 94925 
 (415) 945-5420 • Fax (415) 927-2240 • www.transoral.com 

 Borrower agrees to notify Lender promptly before the funding of the Loan if any of the matters which have
been represented above shall not be true and correct on the Borrowing Date and if Lender has received no such notice before the Advance Date then the statements set forth above shall be deemed to have been made and shall be deemed to be true and
correct as of the Advance Date. 
 Executed as of May 11, 2006. 
  

			
	BORROWER:	 	TRANSORAL PHARMACEUTICALS, INC.
		
	SIGNATURE:	 	/s/ Thomas P. Soloway
	TITLE:	 	Chief Financial Officer
	NAME:	 	Thomas P. Soloway

 ATTACHMENT TO ADVANCE REQUEST 
 Dated: May 11, 2006 
 Borrower hereby represents and warrants to Lender that Borrower’s
current name and organizational status is as follows: 
  

			
	Name:	  	TransOral Pharmaceuticals, Inc.
		
	Type of organization:	  	Corporation
		
	State of organization:	  	Delaware
		
	Organization file number:	  	3478309

 Borrower hereby represents and warrants to Lender that the street addresses, cities, states and postal codes of
its current locations are as follows: 
 Chief Executive Office, Principal Place of Business, and Location of Collateral: 
 300 Tamal Plaza, Suite 220, Corte Madera, CA 94925 through May 19, 2006. 
 Beginning May 19, 2006, its chief executive office will be located at 1003 West Cutting Blvd., Suite 110, Point Richmond, CA, 94804 

 DEPOSIT ACCOUNT 
 CONTROL AGREEMENT 
 This Deposit Account Control Agreement (this “Agreement”) is
entered into as of March 28, 2006, by and among TransOral Pharmaceuticals, Inc., (“Customer”). Hercules Technology Growth Capital, Inc., (“Secured Party”), and COMERICA BANK (“Bank”), with
reference to the following facts: 
 A. Customer maintains the Deposit Account (as defined below) at Bank’s San Jose Airport Parkway
Branch (the “Banking Office”). 
 B. Customer has granted Secured Party a security interest in the Deposit Account and all
funds now or at any time hereafter held in the Deposit Account. 
 C. Secured Party, Customer and Bank have agreed to enter into this
Agreement to provide for the control of the Deposit Account by Secured Party and to perfect Secured Party’s security interests in the Deposit Account (as each such term is defined below). 
 NOW, THEREFORE, in consideration of the mutual promises and covenants, contained herein the parties hereto mutually agree as follows. 
 ARTICLE 1 - DEFINITIONS 
 1.01
Definitions. As used in this Agreement, the following terms shall have the following meanings: 
 “Business Day”
means any day that is not a Saturday, Sunday, or other day on which banks in the State of California are authorized or required to close. 
 “Code” means the California Uniform Commercial Code, as amended and supplemented from time to time, and any successor statute. 
 “Deposit Account” means Customer’s deposit account (as such term is defined in the Code) with Bank, number 1892563980. 
 “Notice of Exclusive Control” means written notice to Bank which states that an event of default has occurred and is continuing under
the document, instrument or agreement pursuant to which Customer has granted the security interest in the Deposit Account to Secured Party, and that on the basis thereof, Secured Party is exercising exclusive control over the Deposit Account.

 “Order” means any instruction issued by any person with respect to the disposition of any funds contained in the Deposit
Account. 
 1.02 Construction. Any reference herein to any document includes any and all alterations, amendments, extensions,
modifications, renewals, or supplements thereto or thereof, as applicable. Neither this Agreement nor any uncertainty or ambiguity herein shall be construed or resolved against Secured Party, whether under any rule of construction or otherwise. This
Agreement has been reviewed by each of the parties hereto, and their respective counsel. This Agreement shall be construed and interpreted according to the ordinary meaning of the words used so as to fairly accomplish the purposes and intentions of
Customer and Secured Party. 

 ARTICLE 2 - CONTROL 
 2.01 No Withdrawals or Payments After Receipt of Notice of Exclusive Control. Anything contained in Section 2.03 to the contrary notwithstanding, Customer hereby absolutely, irrevocably and unconditionally
authorizes and instructs Bank that, promptly upon receipt of a Notice of Exclusive Control by Bank at the Banking Office, Bank shall: 
 (a) neither accept nor comply with any Order from Customer for the payment of any funds from the Deposit Account to any third person nor permit Customer to withdraw any funds in the Deposit Account without the
specific prior written consent of Secured Party; 
 (b) comply with all Orders originated by Secured Party concerning the
Deposit Account and all other requests or instructions from Secured Party regarding disposition and/or delivery of funds contained in the Deposit Account, without further consent or direction from Customer and without regard to any inconsistent or
conflicting Orders given to Bank by Customer within two (2) Business Days; and 
 (c) anything contained in the foregoing
to the contrary notwithstanding, Secured Party hereby agrees that before it attempts to give Bank any Orders concerning the Account, Secured Party shall deliver to the Banking Office such documentation as Bank may from time to time reasonably
request to evidence the authority of those partners, officers, employees or agents whom Secured Party may designate to give Orders. 
 2.02
Priority of Lien. Bank hereby acknowledges and agrees that: 
 (a) Bank has received notice of the existence of the
security interest of Secured Party in the Deposit Account, and recognizes the security interest granted to Secured Party by Customer; 
 (b) all of Bank’s present and future rights against the Deposit Account are subordinate to Secured Party’s security interest therein; provided, however, that Secured Party hereby acknowledges and agrees that
nothing herein subordinates or waives, and that Bank expressly reserves, all of its present and future rights (whether described as rights of setoff, banker’s lien, security interest, chargeback or otherwise, and whether available to Bank under
the law or under any other agreement between Bank and Customer concerning the Deposit Account, or otherwise) with respect to: (a) items deposited to the Deposit Account and returned unpaid, whether for insufficient funds or for any other
reason, and without regard to the timeliness of return of any such items or the occurrence or timeliness of any drawee’s notice of non-payment of such items; (b) ACH entries credited to the Deposit Account and later reversed, whether for
insufficient funds or for any other reason, and without regard to the timeliness of such entries’ reversal; (c) chargebacks to the Deposit Account of credit card transactions; (d) erroneous entries to the Deposit Account;
(e) overdrafts on the Deposit Account, (f) claims of breach of the transfer or presentment warranties made to Bank pursuant to the Code in connection with items deposited to the Deposit Account; (g) any lien arising in connection with
any loan or other credit relationship between Customer and Bank; and (h) Bank’s usual and customary charges for services rendered in connection with the Deposit Account; and 
 (c) Except as otherwise required by law, Bank shall not enter into any agreement with any third party relating to the Deposit Account or
agree that it will comply with any Orders concerning the Deposit Account originated by any such third party without the prior written consent of Secured Party and Customer. 
 2.03 Control of Deposit Account. At all times during the effectiveness of this Agreement, Customer hereby absolutely, irrevocably and
unconditionally instructs, and Bank hereby agrees, that: 
 (a) Bank shall comply with any Orders or other instructions
concerning the Deposit Account from Secured Party without further consent by Customer. 
  

 2 

 (b) Bank shall not comply with any Orders or other instructions concerning the Deposit
Account, from any third party without the prior written consent of Secured Party and Customer. 
 (c) Except as otherwise
provided in Sections 2.01 and 2.02, prior to the receipt of a Notice of Exclusive Control by Bank at the Banking Office, Bank shall accept and execute Orders from Customer with respect to the payment or withdrawal of any funds from the Deposit
Account or the payment of any funds in the Deposit Account to Customer. 
 2.04 Bank’s Representations, Warranties and
Acknowledgments. 
 (a) Bank represents and warrants to Secured Party that: 
 (i) the Deposit Account has been established and is maintained with Bank at the Banking Office solely in Customer’s name as recited
above; 
 (ii) any balances in the Deposit Account are valid and binding obligations of Bank; 
 (iii) Bank has no knowledge of any claim to, security interest in or lien upon the Deposit Account, except the security interests in favor
of Secured Party and Bank’s liens securing fees and charges, as described in Section 2.02 hereof; 
 (iv) Bank has
not entered into any agreement with any third party regarding the Deposit Account or agreed that it will comply with any Orders concerning the Deposit Account originated by any such third party. 
 2.05 Agreements of Bank and Customer. Bank and Customer agree that: 
 (a) Bank shall send copies of all statements relating to the Deposit Account simultaneously to Customer and to Secured Party; 

(b) Bank may disclose to Secured Party such other information concerning the Account as Secured Party may from time to time request;
provided, however, that Bank shall have no obligation to disclose to Secured Party any information which Bank does not ordinarily make available to its depositors; and 
 (c) Bank shall use reasonable efforts to promptly notify Secured Party and Customer if any other party asserts any claim to, security or
property interest in or lien upon the Deposit Account. 
 2.06 Bank’s Responsibility. Anything contained in the foregoing to the
contrary notwithstanding: 
 (a) Except for permitting a withdrawal in violation of Section 2.01, Bank shall not
be liable to Secured Party for complying with Orders from Customer that are received by Bank before Bank receives and has a reasonable opportunity to act on Notice of Exclusive Control and any contrary Order from Secured Party. 
 (b) Bank shall not be liable to Customer for complying with Orders originated by Secured Party, even if Customer notifies Bank that
Secured Party is not legally entitled to issue Orders, unless Bank takes the action after it is served with an injunction, restraining order, or other legal process enjoining it from doing so, issued by a court of competent jurisdiction, and had a
reasonable opportunity to act on the injunction, restraining order or other legal process. 
  

 3 

 (c) This agreement does not create any obligation of Bank except for those expressly set
forth in this Agreement. In particular, Bank need not investigate whether the Secured Party is entitled under Secured Party’s agreements with Customer to give Orders. Bank may rely on notices and communications it believes are given by the
appropriate party. 
 (d) Bank will not have any liability to Customer or Secured Party for claims, losses, liabilities or
damages suffered or incurred by Customer or Secured Party as a result of or in connection with this agreement except to the extent such losses, liabilities and damages directly result from Bank’s gross negligence or willful misconduct.

 (e) In no event shall Bank have any liability to Customer or Secured Party for any consequential, special, punitive or
indirect loss or damage whether or not any claim for such damages is based on tort or contract or Bank knew or should have known the likelihood of such damages in any circumstances. 
 2.07 Indemnity. 
 (a)
Customer shall indemnify and hold harmless Bank, its officers, directors, employees, and agents against any and all claims, liabilities, demands, damages and expenses arising out of this Agreement (including reasonable attorneys’ fees and
disbursements and the reasonable estimate of the allocated costs and expenses of in-house legal counsel and staff), except to the extent the claims, liabilities, or expenses are caused by Bank’s gross negligence or willful misconduct. Customer
shall indemnify Secured Party for any indemnity obligations Secured Party owes to Bank under this Agreement. 
 (b) Secured
Party shall indemnify and hold harmless Bank, its officers, directors, employees, and agents against any and all claims, liabilities, demands, damages and expenses arising out of this Agreement (including reasonable attorneys’ fees and
disbursements and the reasonable estimate of the allocated costs and expenses of in-house legal counsel and staff), except to the extent the claims, liabilities, or expenses are caused by Bank’s gross negligence or willful misconduct; provided,
however, that in no event shall the Secured Party be liable for any special, consequential, exemplary damages, or lost profits. 
 2.08
Termination, Survival. 
 (a) This Agreement shall terminate: 
 (i) immediately upon receipt by the Bank at the Banking Office of written notice from Secured Party expressly stating that Secured Party
is terminating this Agreement; 
 (ii) immediately upon receipt by the Bank at the Banking Office of written notice from
Secured Party expressly stating that Secured Party’s security interest in the Deposit Account has terminated; or 
 (iii)
thirty (30) days after the receipt by Secured Party and Customer of written notice from Bank stating that it is terminating this Agreement; 
 (b) Sections 2.06, “Bank’s Responsibility,” and Section 2.07, “Indemnity,” shall survive termination of this Agreement. 
  

 4 

 ARTICLE 3 - GENERAL PROVISIONS 
 3.01 Conflicts: Controlling Agreement. As to the matters specifically the subject of this Agreement, in the event of any conflict between this
Agreement and any other agreement between Bank and Customer, the terms of this Agreement shall control. 
 3.02 Final Agreement;
Amendments and Waivers. This Agreement, together with any other document, instrument, or agreement entered into between Customer and Secured Party in connection therewith with respect to the subject matter contained therein constitutes the
entire understanding among each of them with respect to the subject matter thereof. This Agreement supersedes any and all prior oral or written agreements relating to the subject matter hereof. Any provision of this Agreement may be amended or
waived if, but only if, such amendment or waiver is in writing and is signed by the party asserted to be bound thereby, and then such amendment or waiver shall be effective only in the specific instance and specific purpose for which given.

 3.03 Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of the heirs, executors, administrators,
legal representatives, successors and assigns of the parties. 
 3.04 Amendments, Modifications. This Agreement may be amended or
modified only in writing signed by all parties hereto. 
 3.05 Severability of Provisions. If any provision of this Agreement for any
reason is held to be invalid, illegal or unenforceable in any respect, that provision shall not affect the validity, legality or enforceability of any other provision of this Agreement. 
 3.06 Section Headings. Headings and numbers used to identify sections and paragraphs of this Agreement have been set forth herein for convenience
only. Unless the contrary is compelled by the context, everything contained in each section applies equally to this entire Agreement. 
 3.07
Counterparts; Facsimile Execution. This Agreement may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, shall be deemed to be an original, and all of
which, when taken together, shall constitute but one and the same Agreement. Delivery of an executed counterpart of this Agreement by facsimile shall be equally as effective as delivery of a manually executed counterpart of this Agreement. Any party
delivering an executed counterpart of this Agreement by facsimile also shall deliver a manually executed counterpart of this Agreement but the failure to deliver a manually executed counterpart shall not affect the validity, enforceability, and
binding effect of this Agreement. 
 3.08 Notices. All notices, requests and demands which any party is required or may desire to give
to any other party under any provision of this Agreement must be in writing (unless otherwise specifically provided) and delivered to each party at the following address: 
  

			
	Customer	  	TransOral Pharmaceuticals, Inc.
		  	300 Tamal Plaza, Suite 220
		  	Corte Madera, CA 94925
		  	Fax. No. (415) 927-2240
		  	Attn: Chief Financial Officer
		
	Secured Party:	  	Hercules Technology Growth Capital, Inc.
		  	525 University Avenue
		  	Palo Alto, CA 94301
		  	Fax. No. (650) 479-9194
		  	Attn: Chief Legal Officer

  

 5 

			
	Bank:	  	
		  	Comerica Bank
		  	Technology & Life Sciences Division
		  	Five Palo Alto Square
		  	3000 El Camino Real, Suite 800
		  	Palo Alto, CA 94306
		  	Fax. No. (650) 213-1710
		  	Attn: Brian Zacharias
		
		  	With a Copy To:
		
		  	Comerica Bank
		  	75 East Trimble Road
		  	San Jose, CA 95131
		  	FAX: (408) 556-5091
		  	Attn: Manager

 or to such other address or facsimile number as any party may designate by written notice to all other parties.
Each such notice, request and demand shall be deemed given or made as follows: (i) if sent by hand delivery, upon delivery; (ii) if sent by facsimile, upon receipt; provided, however, that in either case, receipt by Bank of any Notice of
Exclusive Control shall not be deemed to have occurred until the Bank delivers written notification (by email, fax or hard copy) confirming receipt to the Secured Party. Bank shall attempt in good faith to deliver written notification confirming
receipt to the Secured Party promptly following Bank’s actual receipt of the Notice of Exclusive Control. 
 3.09 Governing Law.
This Agreement shall be deemed to have been made in the state of California and the validity, construction, interpretation, and enforcement hereof, and the rights of the parties hereto, shall be determined under, governed by, and construed in
accordance with the internal laws of the state of California, without regard to principles regarding the conflicts or choice of law. 
 3.10
WAIVER OF JURY TRIAL. THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES. TO THE EXTENT PERMITTED BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE
OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO THIS AGREEMENT OR ANY
OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES. 
 (a) In the event the Jury Trial Waiver set forth above is not
enforceable, the parties elect to proceed under this Judicial Reference Provision. 
 (b) With the exception of the items specified in clause
(c), below, any controversy, dispute or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any other document, instrument or agreement between the undersigned parties (collectively in this Section,
the “Loan Documents”), will be resolved by a reference proceeding in California in accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure (“CCP”), or their successor sections, which shall
constitute the exclusive remedy for the resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except as otherwise provided in the Loan Documents, venue for the reference proceeding will be in the Superior Court
in the County where the real property involved in the action, if any, is located or in a County where venue is otherwise appropriate under applicable law (the “Court”). 
  

 6 

 (c) The matters that shall not be subject to a reference are the following: (i) nonjudicial
foreclosure of any security interests in real or personal property, (ii) exercise of selfhelp remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv) temporary, provisional or ancillary remedies
(including, without limitation, writs of attachment, writs of possession, temporary restraining orders or preliminary injunctions). This Agreement does not limit the right of any party to exercise or oppose any of the rights and remedies described
in clauses (i) and (ii) or to seek or oppose from a court of competent jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition to, any of those items does not waive the right of any party to a
reference pursuant to this Agreement. 
 (d) The referee shall be a retired Judge or Justice selected by mutual written agreement of the
parties. If the parties do not agree within ten (10) days of a written request to do so by any party, then, upon request of any party, the referee shall be selected by the Presiding Judge of the Court (or his or her representative). A request
for appointment of a referee may be heard on an ex parte or expedited basis, and the parties agree that irreparable harm would result if ex parte relief is not granted. 
 (e) The parties agree that time is of the essence in conducting the reference proceedings. Accordingly, the referee shall be requested, subject to change in the time periods specified herein for good cause shown, to
(i) set the matter for a status and trial-setting conference within fifteen (15) days after the date of selection of the referee, (ii) if practicable, try all issues of law or fact within one hundred twenty (120) days after the
date of the conference and (iii) report a statement of decision within twenty (20) days after the matter has been submitted for decision. 
 (f) The referee will have power to expand or limit the amount and duration of discovery. The referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s failure to provide requested discovery for any
reason whatsoever. Unless otherwise ordered based upon good cause shown, no party shall be entitled to “priority” in conducting discovery, depositions may be taken by either party upon seven (7) days written notice, and all other
discovery shall be responded to within fifteen (15) days after service. All disputes relating to discovery which cannot be resolved by the parties shall be submitted to the referee whose decision shall be final and binding. 
 (g) Except as expressly set forth in this Agreement, the referee shall determine the manner in which the reference proceeding is conducted including the
time and place of hearings, the order of presentation of evidence, and all other questions that arise with respect to the course of the reference proceeding. All proceedings and hearings conducted before the referee, except for trial, shall be
conducted without a court reporter, except that when any party so requests, a court reporter will be used at any hearing conducted before the referee, and the referee will be provided a courtesy copy of the transcript. The party making such a
request shall have the obligation to arrange for and pay the court reporter. Subject to the referee’s power to award costs to the prevailing party, the parties will equally share the cost of the referee and the court reporter at trial.

 (h) The referee shall be required to determine all issues in accordance with existing case law and the statutory laws of the State of
California. The rules of evidence applicable to proceedings at law in the State of California will be applicable to the reference proceeding. The referee shall be empowered to enter equitable as well as legal relief, enter equitable orders that will
be binding on the parties and rule on any motion which would be authorized in a court proceeding, including without limitation motions for summary judgment or summary adjudication. The referee shall issue a decision at the close of the reference
proceeding which disposes of all claims of the parties that are the subject of the reference. Pursuant to CCP § 644, such decision shall be entered by the Court as a judgment or an order in the same manner as if the action had been tried by the
Court and any such decision will be final, binding and conclusive. The parties reserve the right to appeal from the final judgment or order or from any appealable decision or order entered by the referee. The parties reserve the right to findings of
fact, conclusions of laws, a written statement of decision, and the right to move for a new trial or a different judgment, which new trial, if granted, is also to be a reference proceeding under this provision. 
  

 7 

 (i) If the enabling legislation which provides for appointment of a referee is repealed (and no successor
statute is enacted), any dispute between the parties that would otherwise be determined by reference procedure will be resolved and determined by arbitration. The arbitration will be conducted by a retired judge or Justice, in accordance with the
California Arbitration Act §1280 through §1294.2 of the CCP as amended from time to time. The limitations with respect to discovery set forth above shall apply to any such arbitration proceeding. 
 (j) THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED UNDER THIS REFERENCE PROVISION WILL BE DECIDED BY A REFEREE AND
NOT BY A JURY. AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER OWN CHOICE, EACH PARTY KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES THAT THIS REFERENCE PROVISION WILL APPLY
TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER LOAN DOCUMENTS. 
 3.11 Attorney Costs. The prevailing party in any proceeding conducted in accordance with the provisions of Section 3.10 hereof or any other action arising out of this Agreement shall be reimbursed by the non-prevailing party(s)
thereto for all costs and expenses, including reasonable attorneys’ fees (to include outside counsel fees and all allocated costs of the prevailing party’s in-house counsel), expended or incurred by the prevailing party in connection
therewith, in addition to any other remedy or recovery awarded by the court. 
 IN WITNESS WHEREOF, the parties hereto have executed and delivered this
Agreement as of the date set forth in the first paragraph hereof. 
  

									
	CUSTOMER:	 		 	TransOral Pharmaceuticals, Inc.
					
		 		 		 	By:	 	/s/ Glenn A. Oclassen
		 		 		 	Name:	 	Glenn A. Oclassen
		 		 		 	Title:	 	CEO & President
			
	SECURED PARTY:	 		 	Hercules Technology Growth Capital, Inc.
					
		 		 		 	By:	 	/s/ Illegible
		 		 		 	Name:	 	Illegible
		 		 		 	Title:	 	Chief Legal Officer
			
	BANK:	 		 	COMERICA BANK
					
		 		 		 	By:	 	/s/ Illegible
		 		 		 	Name:	 	Illegible
		 		 		 	Title:	 	V.P.

  

 8 

 State Street Bank and Trust Company 
 1200 Crown Colony Drive 
 Quincy, MA 02169

 ATTENTION: Kevin J. Hughes 
  

	 	Re:	TransOral Pharmaceuticals, Inc. 

 Dear Mr. Hughes:

 All terms not defined herein but defined in the Uniform Commercial Code, as in effect from time to time in the Commonwealth of
Massachusetts (the “UCC”), shall have the meanings given to such terms in Articles 8 and 9 of the UCC. 
 For good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the undersigned, (a) TransOral Pharmaceuticals, Inc., a Delaware corporation (the “Borrower”), (b) Capital Advisors
Group (the “Investment Manager”), (c) Hercules Growth Technology Capital, (the “Lender”) and (d) STATE STREET BANK AND TRUST COMPANY, a Massachusetts trust company (the
“Securities Intermediary”), intending to be legally bound, do hereby agree as follows: 
  

	1.	Establishment of Account. 

 The Securities
Intermediary hereby confirms that a certain account (Account No. DE2275) (the “Account”), identified in the books of the Securities Intermediary in the name of the Borrower, has been established with and is held by the
Securities Intermediary. The Account is an account to which financial assets may be credited in accordance with this Agreement. 
  

	2.	Acknowledgement of Security Interest. 

 The Borrower
and Securities Intermediary are parties to one or more agreements governing or relating to the establishment and administration of the Account (referred to herein, collectively if more than one, as the “Custodial Agreement”). The
Securities Intermediary hereby acknowledges that the Borrower has notified the Securities Intermediary that the Borrower has granted to the Lender a security interest in the Borrower’s rights and interests in and to the Account and all
entitlements to any and all securities, investment property and other financial assets which are now or hereafter may be deposited in and credited to the Account, and in all cash balances that are credited to the Account from time to time, and in
all proceeds of any of the foregoing (collectively, the “Account Assets”). The initial Account Assets as of the close of business on March 31, 2006, are listed on Exhibit A hereto and incorporated
herein by reference. 

 State Street Bank and Trust Company 
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	3.	Account Control. 

 3.1 Borrower Control.

 (i) Unless and until the Securities Intermediary receives written notice from the Lender directing the Securities
Intermediary that the Lender is exercising its right to exclusive control over the Account, which notice is substantially in the form attached hereto as Exhibit B (a “Notice of Exclusive
Control”), or if all previous Notices of Exclusive Control have been revoked or rescinded in writing by the Lender, the Borrower (or, until the Investment Manager’s receipt of notice from the Lender that it is
exercising exclusive control over the Account, the Investment Manager pursuant to the Custodial Agreement) shall be entitled to exercise all rights with respect to, and to direct the Securities Intermediary with respect to, the Account and the
Account Assets, including, but not limited to, the investment and re-investment of the Account Assets and the Securities Intermediary shall be entitled to deal with the Borrower (or the Investment Manager pursuant to the Custodial Agreement) as the
sole and absolute owner thereof, including without limitation the sale, liquidation, purchase, trading, transfer, delivery, withdrawal, release or payment of any Account Assets, including any cash balances. 
 (ii) The Securities Intermediary shall have no responsibility or liability to the Lender for settling trades of financial assets carried
in the Account at the direction of and in accordance with the instructions of the Borrower or the Investment Manager given in accordance with the Custodial Agreement, or for complying with entitlement orders concerning any Account Assets from the
Borrower, if received by the Securities Intermediary prior to receipt of a Notice of Exclusive Control from the Lender. 
 3.2 Control by
Lender. 
 (i) Upon receipt by the Securities Intermediary of a Notice of Exclusive Control, the Securities Intermediary
shall thereafter follow only the instructions of the Lender with respect to the Account and the Account Assets, and shall comply with any entitlement order (within the meaning of Section 8-102(a)(8) of the UCC) received from the Lender, without
further consent of the Borrower or any other person, and notwithstanding any demand or notice to the contrary from the Borrower. 
 (ii) The Securities Intermediary shall be authorized to follow the instruction or any entitlement order of the Lender pursuant to this Section 3.2 with respect to the Account and the Account Assets in all respects and shall be entitled
to deal with the Lender as though the Lender were the sole and absolute owner of the Account and Account Assets, including without limitation with respect to the sale, liquidation, purchase, delivery, trading, transfer, withdrawal, release or
payment of any Account Assets, including any cash balances credited to the Account. 
 (iii) The Securities Intermediary shall
have no responsibility or liability to the Borrower for complying with a Notice of Exclusive Control or complying with entitlement orders concerning any Account Assets originated by the Lender. The 

 State Street Bank and Trust Company 
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Securities Intermediary shall have no duty to investigate or make any determination as to whether a default or an event of default exists under any credit
agreement between the Borrower and the Lender, and the Securities Intermediary shall comply with a Notice of Exclusive Control whether or not the Borrower may allege that no such default or event of default exists. 
 (iv) Concurrently with notifying the Securities Intermediary that it is exercising or rescinding its right of exclusive control over the
Account, the Lender shall also provide written notice to the Investment Manager of such exercise or rescission. 
  

	4.	Lender Security Interest. 

 This Agreement is
intended by the Borrower and Lender to grant “control” of the Account Assets to the Lender for purposes of perfection of the Lender’s security interest in the Account Assets pursuant to Article 8 and Article 9 of the UCC.
Notwithstanding the foregoing, the Securities Intermediary makes no representation with respect to and shall have no responsibility for the sufficiency of this Agreement for such purpose. 
  

	5.	Indemnification. 

 In addition to the indemnities
set forth in the Custodial Agreement, the Borrower hereby agrees to indemnify and hold the Securities Intermediary harmless from and against all liabilities, obligations, losses, damages, claims, costs and expenses (including without limitation
attorney’s fees and costs) which may be asserted against or incurred or suffered by the Securities Intermediary arising out of this Agreement or the performance of the Securities Intermediary’s agreements or duties hereunder, or as a
consequence of any action or omission by the Securities Intermediary pursuant to the terms of this Agreement (except for such claims which have been determined by a court of competent jurisdiction to have resulted from the Securities
Intermediary’s willful misconduct or gross negligence). The Lender agrees to indemnify and hold the Securities Intermediary harmless from and against any and all liabilities, obligations, losses or claims which may arise as a result of the
Securities Intermediary acting in accordance with any notice, instruction, direction or advice received from the Lender pursuant to the terms of this Agreement (except for such claims which have been determined by a court of competent jurisdiction
to have resulted from the Securities Intermediary’s willful misconduct or gross negligence). THE SECURITIES INTERMEDIARY SHALL NOT BE LIABLE IN ANY EVENT TO ANY PERSON, INCLUDING ANY PARTY HERETO, FOR ANY SPECIAL, INCIDENTAL OR CONSEQUENTIAL
DAMAGES WHICH ANY PERSON OR PARTY MAY INCUR OR SUFFER IN CONNECTION WITH THIS LETTER AGREEMENT, REGARDLESS OF WHETHER THE SECURITIES INTERMEDIARY KNEW OF THE LIKELIHOOD OF SUCH LOSS OR DAMAGE. This paragraph shall survive termination of this
Agreement and the satisfaction or termination of the Lender’s interest in the Account. 

 State Street Bank and Trust Company 
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	6.	Force Majeure. 

 The Securities Intermediary shall
not be liable for delays or errors occurring by reason of circumstances beyond the control of the Lender, including, without limitation, acts of civil, military, or banking authorities, national emergencies, market disorder, labor difficulties,
fire, flood or other catastrophes, acts of God, terrorism, insurrection, war, riots, failure of transportation or equipment, or failure of vendors, communication or power supply. In no event shall the Securities Intermediary be liable to any person
for consequential damages, exemplary damages, special damages, indirect damages, or lost profits, even if the Securities Intermediary has been advised of the possibility or likelihood of such damages. The provisions of this paragraph shall survive
termination of this Agreement and the Lender’s interest in the Account. 
  

	7.	Duties of Securities Intermediary; No Implied Obligations. 

 (i) The Securities Intermediary shall have no duties, obligations, responsibilities or liabilities with respect to the Account or the Account Assets except as and to the extent expressly set forth in this Agreement
and the Custodial Agreement, and no implied duties of any kind shall be read into this Agreement against the Securities Intermediary. 
 (ii) Except for the rights of control in favor of the Lender agreed to herein, nothing herein shall be deemed to modify, limit, restrict, amend or supersede the terms of the Custodial Agreement, and Securities
Intermediary shall remain entitled to all of the rights, indemnities, powers, immunities and protections in its favor under the Custodial Agreement. The Securities Intermediary does not herein waive or agree to subordinate, and the Securities
Intermediary hereby expressly reserves, any lien, security interest and rights of offset which it is granted or to which it is entitled under the Custodial Agreement and/or applicable law. 
 (iii) Without limiting the generality of the foregoing, in no instance shall the Securities Intermediary be under any obligation to take
any action to preserve, protect or exercise rights in the Account Assets (except to the extent that may be expressly required by the terms of the Custodial Agreement). It is understood that the Securities Intermediary shall have at no time any
responsibility (a) for determining the value of the Account Assets, (b) for any market decline in the value of the Account Assets or (c) for notifying any person of any such decline in market value of the Account Assets. 

(iv) The Lender hereby expressly acknowledges that the Account may include Account Assets in the nature of securities entitlements in
favor of the Securities Intermediary in one or more securities accounts at one or more underlying securities intermediaries in which or through which underlying assets, or entitlements thereto, are held or credited (including without limitation,
with respect to federal book-entry securities, a “security entitlement” within the meaning of applicable federal book-entry regulations). The Securities Intermediary shall have no liability for the actions or omissions of, or any errors or
omissions in the records of, any such underlying securities intermediary. 

 State Street Bank and Trust Company 
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 (v) All securities and investment property now or hereafter held in the Account shall
be treated as “financial assets” within the meaning of Section 8-102(a)(9) of the UCC. 
 (vi) The parties
hereto acknowledge that no “security entitlement” under the UCC shall exist with respect to any financial asset held in the Account which is registered in the name of the Borrower, payable to the order of the Borrower or specially indorsed
to the Borrower (each such asset an “Identified Security”), except to the extent such Identified Security has been specially indorsed by the Borrower to the Securities Intermediary or in blank. The parties further acknowledge and agree
that any such Identified Securities received by it and credited to the Account from time to time shall (so long as so credited to the Account and so long as this Agreement remains in effect) be held by the Securities Intermediary (directly or
through a Sub-Custodian, as defined below, as applicable) for the benefit of the Lender, not in its capacity as a “securities intermediary” (as defined in the UCC), but in its capacity as a custodial agent under and subject to the terms of
this Agreement. 
 (vii) For avoidance of doubt, the Lender hereby acknowledges that any Account Assets issued outside the
United States (“Foreign Security System Assets”) and held in the Account, which are held by the Securities Intermediary, a sub-custodian within the Securities Intermediary’s network of sub-custodians (each a
“Sub-Custodian”) or a depository or book-entry system for the central handling of securities and other financial assets in which the Securities Intermediary or the Sub-Custodian are participants (each, a
“Securities System”) may not permit the Borrower to have a security entitlement under the UCC with respect to such Foreign Security System Assets (and such property shall be deemed for purposes of this Agreement not to be a
financial asset held within the Account). 
 (viii) The Securities Intermediary shall not change the name or the account
number of the Account without the prior written consent of the Borrower and the Lender. 
  

	8.	Standard of Care. 

 8.1 Custodial Agreement.
In no event shall the Securities Intermediary be liable for its failure to perform under the terms of this Agreement, except to the extent that the Securities Intermediary has acted with gross negligence or willful misconduct. The Securities
Intermediary shall not be responsible for the sufficiency of this Agreement or the arrangement contemplated hereby to create, cause to attach or perfect, any security interest in favor of the Lender. 
 8.2 No Implied Duties. The Securities Intermediary shall have no responsibilities, obligations or duties other than those expressly set forth in
this Agreement and the Custodial Agreement, and no implied duties, responsibilities or obligations shall be read into this Agreement against the Securities Intermediary; without limiting the generality of the foregoing, the Securities Intermediary
shall have no duty to preserve, exercise or enforce rights in the Account Assets (against prior parties or otherwise). 

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 8.3 Borrower Instruction. As between the Borrower and the Securities Intermediary, except as
may be otherwise expressly stated herein, the liabilities of each to the other shall be governed by the provisions of the Custodial Agreement. Instructions from a Borrower’s Authorized Representative given in accordance with the terms of the
Custodial Agreement to the Securities Intermediary hereunder shall also constitute Proper Instructions (as defined in the Custodial Agreement) under the Custodial Agreement. Upon the Investment Manager’s receipt from the Lender of the
Lender’s exercise of exclusive control over the Account, the Borrower acknowledges that the Investment Manager shall have no responsibility for investing and reinvesting the Account Assets, until such time as written notice of the Lender’s
revocation of such exclusive control is received by the Investment Manager. 
 8.4. Lender Instruction. Notwithstanding any provision
contained herein or in any other document or instrument to the contrary, the Securities Intermediary shall not be liable for any action taken or omitted to be taken at the instruction of the Lender, or any action otherwise taken or omitted to be
taken under, in connection with, or pursuant to the terms of this Agreement, except for in the case of (and to the extent of) the Securities Intermediary’s own gross negligence or willful misconduct. 
 8.5 Certain Immunities and Protections. In no event shall the Securities Intermediary be liable for indirect, special, punitive or consequential
damages of any kind, even if advised of the possibility of such damages. Without limiting the generality of the foregoing, and notwithstanding any provision to the contrary contained herein, the Securities Intermediary: 
 (i) may in any instance where the Securities Intermediary reasonably determines that it lacks authority to take or refrain from taking
certain action, or as to the requirements of this Agreement under any circumstance before it, delay or refrain from taking action unless and until it has received appropriate instructions hereunder; provided, however, that under no circumstances
shall this clause (i) be construed as requiring the Securities Intermediary to obtain the consent of the Borrower in order to comply with any entitlement order originated by the Lender hereunder; 
 (ii) may consult with legal counsel, independent public accountants, or other experts selected by it in good faith, and shall not be
liable for any action taken or omitted to be taken in good faith in accordance with the advice of such experts; 
 (iii) will
have no duty to ascertain or inquire as to the performance or observance by the Borrower of any of the terms, conditions or covenants of this Agreement, or as to the terms of (or the Borrower’s or Lender’s compliance with) any credit
agreement or related security agreement between the Borrower and Lender, or to inspect the property, books or records of the Borrower; 
 (iv) except for the representations of the Securities Intermediary set forth in Section 10, will not be responsible for the due execution, legality, validity, enforceability, genuineness, effectiveness or
sufficiency of this Agreement; 

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 (v) will not incur any liability by acting or not acting in reliance upon any notice,
consent, certificate, statement or other instrument or writing reasonably believed by it to be genuine and to be signed or sent by the proper party or parties; 
 (vi) will not incur liability for any notice, consent, certificate, statement, wire instruction, telecopy, or other writing which is
delayed, canceled or changed without the actual knowledge of the Securities Intermediary; 
 (vii) shall not be deemed to have
or be charged with notice or knowledge of any fact or matter unless a written notice thereof has been received by the Securities Intermediary at the address designated in (or as subsequently designated pursuant to) this Agreement; 
 (viii) shall not be required by any provision of this Agreement to expend or risk the Securities Intermediary’s own funds, or to take
any action (including but not limited to the institution or defense of legal proceedings) which in its reasonable judgment could cause it to incur or suffer any significant expense or liability (including but not limited to reasonable
attorneys’ fees and disbursements), unless and until security or indemnity in form and amount reasonably satisfactory to the Securities Intermediary shall have been provided therefore; 
 (ix) shall not incur any liability for acts or omissions of any domestic or foreign depository, securities intermediary or book-entry
system for the central handling of financial assets (except to the extent provided in the Custodial Agreement, if applicable); and 
 (x) except as expressly set forth herein, shall not be responsible for the title, validity or genuineness of any Account Asset carried in the Account at any time or times. 
  

	9.	Compliance with Legal Process and Judicial Orders. 

 The Securities Intermediary shall have no responsibility or liability to the Borrower or to the Lender or to any other person or entity for acting in accordance with any judicial or arbitral process, order, writ, judgment or decree relating
to the Account Assets subject to this Agreement notwithstanding that such order or process is subsequently modified, vacated or otherwise determined to have been without legal force or effect. 
  

	10.	Representations and Warranties; Covenants. 

 10.1
General Representations. Each of the parties to this Agreement represents and warrants to the other parties to this Agreement as follows: 
 (i) it is duly organized and existing under the laws of the jurisdiction of its organization with full power and authority to execute and deliver this Agreement and to perform all of the duties and obligations to be
performed by it under this Agreement; and 

 State Street Bank and Trust Company 
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 (ii) this Agreement has been duly authorized, executed and delivered by it, and
constitutes its valid, legal and binding obligation enforceable against it in accordance with its terms, except as enforceability may be limited by bankruptcy, insolvency or other similar laws of general application relating to or affecting the
enforcement of creditors’ rights in general or by general principles of equity whether considered in a proceeding at law or equity. 
 10.2 Securities Intermediary Representations. The Securities Intermediary represents, warrants, covenants, agrees and confirms, as of the date hereof, and at all times until the termination of this Agreement: 
 (i) that in the ordinary course of its business the Securities Intermediary maintains securities accounts for others, and that it is
acting in that capacity with respect to the Account; 
 (ii) that there are to its knowledge no other agreements entered into
between the Securities Intermediary and the Borrower with respect to the Account except for this Agreement, the Custodial Agreement and any related fee agreement, funds transfer agreement and data access agreement; 
 (iii) that the Securities Intermediary has not entered into, and until the termination of this Agreement will not enter into, any
agreement (other than the Custodial Agreement) with any other person or entity relating to the Account or the Account Assets under which it has agreed to comply with entitlement orders (as defined in of the UCC) of such other person or entity; and

 (iv) that the Securities Intermediary has not entered into, and until the termination of this Agreement will not enter
into, any agreement with the Borrower or any other person or entity, purporting to revoke, limit or condition the agreement of the Securities Intermediary set forth in this Agreement to comply with entitlement orders of the Lender, as set forth
herein, without the Lender’s express written consent. 
 10.3 Notice of Third Party Claims. If the Securities Intermediary
receives written notice that any person or entity asserts a lien, encumbrance or adverse claim (including any writ, garnishment, judgment, warrant of attachment, execution or similar process) against the Account, the Securities Intermediary will
undertake reasonable efforts promptly to notify the Lender and the Borrower thereof (but shall have no liability in the event of any delay or failure on its part to do so). 
 10.4. The Investment Manager is executing this Agreement for the purpose of acknowledging (i) receipt of this Agreement and (ii) knowledge of
its terms and conditions. 

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	11.	Further Agreements. 

 11.1 Settlement By
Borrower. The Borrower agrees with the Securities Intermediary that assets of the Borrower shall not be deposited, delivered or held in the Account until such assets have been fully paid by the Borrower. 
 11.2 No Borrower Contravention of Lender Control. After the Lender has delivered a Notice of Exclusive Control to the Securities Intermediary,
unless such Notice of Exclusive Control is revoked in writing by the Lender, the Borrower agrees that it shall not give any instruction to the Securities Intermediary in respect to the Account or Account Assets without the prior written consent of
the Lender. 
 11.3 Notice of Default. The Lender agrees that it shall, promptly after becoming aware of the Securities
Intermediary’s failure to perform or observe any term, covenant or agreement on its part to be performed or observed hereunder, deliver to the Borrower notice thereof setting forth in reasonable detail the circumstances of such failure.

  

	12.	Access to Reports; Tax Reporting. 

 12.1
Information Sharing. The Borrower hereby authorizes the Securities Intermediary to forward directly to the Lender a copy of the monthly statement of the Account which is provided by the Securities Intermediary to the Borrower; provided,
however, that the Securities Intermediary failure not to forward a copy of such statement to the Lender shall not give rise to any liability hereunder. 
 12.2 Tax Reporting. All items of income, gain, expense and loss recognized in the Account which the Securities Intermediary determines that it is required by law to report to the Internal Revenue Service or any
other taxing authorities shall be reported to the Internal Revenue Service or such taxing authorities under the name and taxpayer identification number of the Borrower. 
  

	13.	Interpleader. 

 Notwithstanding any provision
contained in this Agreement to the contrary, in the event the Securities Intermediary believes, in its reasonable opinion, that (i) a bona fide dispute exists concerning this Agreement or the disposition of any of the Account or the Account
Assets, (ii) a person or entity makes a claim against the Account or the Account Assets, or (iii) any action under any bankruptcy, insolvency or similar law is commenced relating to the Borrower, the Securities Intermediary shall have the
absolute right, at its election, to petition a court of competent jurisdiction as to the appropriate action to be taken and either deliver the Account Assets to the court in which the action is commenced or freeze the Account pending receipt of such
court direction or order, whereupon the Securities Intermediary shall thereby be relieved from any further liability respecting the Account and the Account Assets and shall be held harmless by the Borrower, Investment Manager and the Bank in taking
any action or refraining from taking any action if done pursuant to any direction or order given by such court. 

 State Street Bank and Trust Company 
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	14.	Fees and Expenses of Securities Intermediary. 

 14.1
Compensation. The Securities Intermediary shall be entitled to, and the Borrower hereby agrees to pay to the Securities Intermediary, compensation in accordance with the terms of the Custodial Agreement. 
 14.2 Reimbursement For Costs. In addition to the terms of the Custodial Agreement, the Borrower hereby agrees to pay and reimburse the Securities
Intermediary for any advances, costs, expenses (including without limitation reasonable attorney’s fees and costs) and disbursements that may be paid or incurred by the Securities Intermediary in connection with, this Agreement or the
arrangement contemplated hereby, including any that may be incurred in performing its duties or responsibilities pursuant to the terms of this Agreement. 
 14.3 Liens. Any amounts that may be owing to the Securities Intermediary from time to time pursuant to the terms of, or as described in, this Section 14 and/or Section 5 hereof shall be deemed to be
amounts owing under the Custodial Agreement, and shall be deemed to be secured by any lien, encumbrance and other rights that the Securities Intermediary may have under the Custodian Agreement and/or applicable law; and the Securities Intermediary
shall be entitled to exercise such rights and interests in accordance with the terms of the Custodial Agreement. 
 14.4 Advances.
Without limiting the generality of the foregoing, it is hereby expressly acknowledged and agreed by the parties that the Securities Intermediary (including its affiliates, subsidiaries and agents) shall not be obligated to advance cash or
investments to, for or on behalf of the Borrower; however, if the Securities Intermediary, or its affiliates, subsidiaries or agents, does advance cash or investments for any purpose (including but not limited to securities settlements, foreign
exchange contracts, assumed settlement or account overdraft) for the benefit of the Borrower, or in the event that the Securities Intermediary or its nominee shall incur or be assessed any taxes, charges, expenses, assessments, claims or liabilities
in connection with the performance of this Agreement, except such as may arise from the Securities Intermediary’s or its nominee’s own gross negligence, bad faith or willful misconduct, any property at any time held pursuant to this
Agreement shall be security therefore and should the Borrower fail to repay the Securities Intermediary promptly, the Securities Intermediary shall be entitled to utilize available cash and to dispose of Collateral assets to the extent necessary to
obtain reimbursement. 
  

	15.	Termination. 

 (a) This Agreement may be terminated
by the Securities Intermediary at any time upon not less than thirty (30) days written notice to the Borrower and the Lender. In such event, the Borrower and the Lender shall within twenty (20) days of such notice notify the Securities
Intermediary in writing of the appointment of a successor Securities Intermediary (including name, address, contact person and telephone number) and shall give written instruction to the Securities Intermediary to deliver the Account Assets to such
successor Securities Intermediary. In the event of the failure of the Borrower and Lender to give such written notification and instruction within such twenty (20) days, the Securities Intermediary shall be entitled to petition a court of
competent jurisdiction to appoint a successor (and otherwise to exercise its rights pursuant to Section 13 hereof). 

 State Street Bank and Trust Company 
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 (b) Upon the sooner to occur of (i) the Securities Intermediary’s receipt of notice of the
termination or release of the Lender’s claim hereunder as provided in Section 16.2 hereof, (ii) delivery of the Account Assets to a successor Securities Intermediary pursuant to Section 15.6(a) hereof, or (iii) the
termination of the Account in accordance with the Custodial Agreement and distribution or application of the Account Assets in accordance with the terms of this Agreement, this Agreement shall terminate and all obligations and duties of the
Securities Intermediary hereunder shall immediately terminate and be discharged. 
  

	16.	Miscellaneous. 

 16.1 Authorization. The
Borrower hereby directs the Securities Intermediary to comply with the terms of this Agreement. 
 16.2 Release of Security Interest.
The Lender agrees to notify the Securities Intermediary promptly in writing when all obligations of the Borrower to the Lender under the credit agreement between the Borrower and Lender have been fully paid and satisfied (and any commitment of the
Lender to advance further amounts or credit thereunder has been terminated) or the Lender otherwise no longer claims any interest in the Account Assets, whichever is soonest; at which time the Securities Intermediary shall have no further
liabilities or responsibilities hereunder and the Securities Intermediary’s obligations under this Agreement shall terminate. 
 16.3
Notices. All notices, requests and demands to or upon the respective parties hereto shall be in writing (including by facsimile transmission) and may be sent by hand, or by confirmed facsimile transmission (confirmed promptly by mailing of
the original) or by telex, answer back received, or delivery by any recognized delivery service, prepaid, or by certified or registered mail, return receipt requested, postage prepaid, and addressed as follows, or to such other address as any party
may hereafter notify the other respective parties hereto in writing: 
  

					
	 (a)
	  	If to the Securities Intermediary,
		  	then:	  	State Street Bank and Trust Company
		  		  	1200 Crown Colony Drive
		  		  	Quincy, MA 02169
		  		  	Attn: Kevin J. Hughes – Vice President
			
	 (b)
	  	If to the Lender,	  	
		  	then:	  	Hercules Technology Growth Capital
		  		  	Legal Department
		  		  	525 University Ave., Suite 700
		  		  	Palo Alto, CA 94301
		  		  	Facsimile: 650-473-9194
		  		  	Telephone: 650-289-3068
		  		  	Attention: Chief Legal Officer and Kathy Conte

 State Street Bank and Trust Company 
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	 (c)
	  	If to the Borrower,
		  	then:	  	TransOral Pharmaceuticals, Inc.
		  		  	1003 West Cutting Blvd.
		  		  	Suite 110
		  		  	Pt. Richmond, CA 94804
		  		  	Attn: Glenn A. Oclassen, CEO
		  		  	Phone: (415) 215-3500
		  		  	Fax: (415) 215-3535
		
	 (d)
	  	If to the Investment Manager,
		  	then:	  	Capital Advisors Group
		  		  	29 Crafts Street Suite 270
		  		  	Newton, MA 02458
		  		  	Attn: Ben Campbell

 16.4 Additional Information. 
 The Borrower, the Lender and the Investment Manager shall provide to the Securities Intermediary any information or documents and execute any document or
instrument which the Securities Intermediary deem necessary or appropriate to perform its obligations hereunder. 
 16.5 Amendments in
Writing; Counterparts. This Agreement may be amended or modified only in a written document signed by all of the parties hereto. This Agreement may be executed in two or more counterparts, each of which shall constitute an original, but such
counterparts together shall constitute one and the same instrument. Any proof of this Agreement shall require production of only one such counterpart. 
 16.6 Severability. If any provision of this Agreement or any portion of such provision, or the application thereof to any person or circumstance, shall to any extent be prohibited or held invalid or
unenforceable, the remainder of this Agreement or the remainder of such provision and the application thereof to other persons or circumstances (other than those as to which it is prohibited or held invalid or unenforceable) shall not be affected
thereby, and each term and provision hereof shall be valid and enforced to the fullest extent permitted by law. To the extent permitted by law, the parties hereto waive any provision of law which renders any such provision or the application thereof
to any person or circumstance prohibited, invalid or unenforceable in any respect. 
 16.7 Successors. This Agreement shall be binding
upon the parties hereto and their respective successors and assigns. 
 16.8 Governing Law; Jurisdiction of Securities Intermediary.
Each of the parties hereby agrees that this Agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts, without giving effect to the conflict of law provisions thereof, and that the Securities
Intermediary’s jurisdiction, for purposes of Section 8- 110(e) of the UCC as it pertains to this Agreement, the Account and the security entitlements relating to the financial assets (including without limitation, the Account Assets)
credited to or otherwise deposited or held in the Account, shall be the Commonwealth of Massachusetts. 

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 16.9 Assignment. All of the terms of this Agreement shall be binding upon and inure to the
benefit of and be enforceable by the parties hereto and their respective successors and assigns; provided, that no party may assign or transfer any of its rights or obligations hereunder without the prior written consent of the other parties
hereto. 
 16.10 Headings. Any headings appearing on this Agreement are for convenience only and shall not affect the interpretation
of any of the terms of this Agreement. 
 16.11 Counterparts. This Agreement may be executed simultaneously in any number of
counterparts each of which when so executed and delivered shall be an original but all of which shall constitute but one and the same document. 
 [THE REMAINDER OF THIS PAGE IS LEFT BLANK INTENTIONALLY] 

 State Street Bank and Trust Company 
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 IN WITNESS WHEREOF, the undersigned have executed this Agreement under their respective seals as of
May 19, 2006. 
  

			
	STATE STREET BANK AND TRUST COMPANY
		
	By:	 	/s/ Kevin J. Hughes
	Name: Kevin J. Hughes
	Title: Vice President
	Its duly authorized officer

  

			
	TRANSORAL PHARMACEUTICALS, INC.
		
	By:	 	/s/ Glenn A. Oclassen
	Name: Glenn A. Oclassen
	Title: President & Chief Executive Officer
	Its duly authorized officer

  

			
	HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
		
	By:	 	/s/ Scott Harvey
	Name: Scott Harvey
	Title: Chief Legal Officer
	Its duly authorized officer

  

			
	CAPITAL ADVISORS GROUP
		
	By:	 	/s/ Benjamin Campbell
	Name: Benjamin Campbell
	Title:

 DESCRIPTION OF INITIAL SECURITIES 
 Exhibit A 
 TRANSORAL PHARMACUETICALS, INC. 
 PORTFOLIO 
 4/28/2006

  

												
	 TICKER
	  	% OF
HOLDINGS	 	 	 INSTRUMENT (RATING)
	  	INVESTMENT
AT COST	  	YIELD TO
MATURITY	 
	 MMF
	  	16.69	%	 	EVERGREEN INSTITUTIONAL MMF	  	$	2,887,804	  	4.68	%
	 C
	  	8.72	%	 	CITIGROUP (AA1/AA-)	  	$	1,508,160	  	4.53	%
	 MBNAS
	  	8.72	%	 	MBNA CREDIT CARD MASTER NOTE TRUST (AAA/AAA)	  	$	1,507,734	  	4.57	%
	 LEH
	  	4.37	%	 	LEHMAN BROTHERS (A1/A+)	  	$	755,460	  	4.56	%
	 SOCNAM
	  	4.06	%	 	SOCIETE GENERALE (AA3/A+)	  	$	702,114	  	4.99	%
	 CCCIT
	  	2.90	%	 	CITIBANK CREDIT CARD ISSUANCE TRUST (AAA/AAA)	  	$	501,016	  	4.90	%
	 BAC
	  	1.45	%	 	MBNA AMERICA BANK (AA1/AA)	  	$	251,488	  	4.81	%
	 AAB
	  	8.80	%	 	ABN AMRO(A1/A+)	  	$	1,522,185	  	4.66	%
	 STI
	  	5.87	%	 	SUNTRUST BANK (Al/A)	  	$	1,015,870	  	4.63	%
	 CHAMT
	  	2.90	%	 	CHASE CREDIT CARD MASTER TRUST (AAA/AAA)	  	$	502,441	  	4.72	%
	 BCSFUN
	  	1.42	%	 	BARCLAYS US FUNDING (A1+/P1)	  	$	244,981	  	4.92	%
	 CALYON
	  	4.26	%	 	CALYON NORTH AMERICA (A1+/P1)	  	$	737,522	  	5.10	%
	 CCE
	  	4.31	%	 	COCA-COLA ENTERPRISES (A2/A)	  	$	745,890	  	4.87	%
	 COMT
	  	1.45	%	 	CAPITAL ONE MASTER TRUST (AAA/AAA)	  	$	250,557	  	4.90	%
	 CCE
	  	1.45	%	 	COCA-COLA ENTERPRISES (A2/A)	  	$	250,238	  	5.04	%
	 LEH
	  	5.90	%	 	LEHMAN BROTHERS (A1/A+)	  	$	1,020,620	  	4.72	%
	 CALYON
	  	2.83	%	 	CALYON NORTH AMERICA (A1+/P1)	  	$	489,476	  	5.16	%
	 CCE
	  	2.33	%	 	COCA-COLA ENTERPRISES (A2/A)	  	$	403,104	  	4.73	%
	 AIG
	  	5.81	%	 	INTERNATIONAL LEASE FINANCE (A1/AA-)	  	$	1,005,060	  	4.95	%
	 COMT
	  	2.88	%	 	CAPITAL ONE MASTER TRUST (AAA/AAA)	  	$	498,711	  	5.21	%
	 DE
	  	2.89	%	 	JOHN DEERE (A3/A-)	  	$	500,005	  	5.12	%
		  			 	TOTAL	  	$	17,300,435	  	4.77	%
		  			 		  	 	 	  	 	 

 State Street Bank and Trust Company 
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 041102 
  

 NOTICE OF EXCLUSIVE CONTROL 
 Exhibit B 
 State Street Bank and Trust Company 
 1200 Crown Colony Drive 
 Quincy, MA 02169 
 Attention:    Kevin J. Hughes 
 NOTICE
OF EXCLUSIVE CONTROL 
 We hereby instruct you pursuant to the terms of that certain Account Control Agreement dated as of March 31,
2003 (as from time to time amended and supplemented, the “Control Agreement”) among the undersigned                      (the
“Lender”), Capital Advisors Group (the “Investment Manager”),                      (together with its successors and
assigns, the “Borrower”) and you, as Securities Intermediary, that you (i) shall not follow any instructions or entitlement orders of the Borrower in respect of the Account or the Collateral (as each such capitalized term is defined
in the Control Agreement), and (ii) unless and until otherwise expressly instructed by the undersigned, shall exclusively follow the entitlement orders and instructions of the undersigned in respect to the Account or the Collateral. 

 

			
	Very truly yours,
		
	By:	 	 
		 	Authorized Signatory
		
	cc:	 	
		 	Capital Advisors Group

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