Document:

Resignation and Release Agreement

 Exhibit 10.41 
 RESIGNATION AND RELEASE AGREEMENT 
 This Resignation and Release Agreement
(the “Agreement”) is made between Colin Stewart (“Executive”) and Amarin Corporation plc (the “Company,” together with Executive, the “Parties”). 

WHEREAS, the Parties entered into a letter agreement dated August 16, 2010 (the “Offer Letter”); 

WHEREAS, Executive resigned from his employment effective November 10, 2010 for personal reasons (the “Resignation
Date”); 
 WHEREAS, the Parties have agreed to enter into an amicable arrangement relating to the resignation of
Executive’s employment that among other things, provides Executive with certain severance payments and benefits in exchange for Executive’s release of all claims against the Company and related persons and entities including, without
limitation, with respect to any claim for severance pay or benefits pursuant to the Offer Letter or otherwise; 
 NOW,
THEREFORE, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties hereby agree as follows: 
 1. Resignation from Officer and Director Positions. Executive hereby resigns from the positions of President and Chief Executive Officer of the Company as well as from any other officer or
director positions that Executive holds with the Company or any entities affiliated with the Company, including without limitation Amarin Pharma, Inc. and any other subsidiary of the Company, effective on the Resignation Date. Executive hereby
agrees to sign any other documents that the Company may reasonably request in order to effectuate such resignation(s). 
 2.
Non-Contingent Accrued Obligations. The Company shall pay the Executive’s salary plus his accrued but unused vacation earned through the Resignation Date. The Company will also reimburse Executive for any outstanding, reasonable
business expenses that Executive has incurred on the Company’s behalf through the Resignation Date, provided the Company receives appropriate documentation pursuant to the Company’s business expense reimbursement policy on or before
November 30, 2010. With respect to any employee benefits, Executive will be treated as a terminated employee effective on the Resignation Date. 
 3. Severance Payments. Provided Executive enters into and complies with this Agreement, the Company shall provide Executive with severance payments in the form of (i) salary
continuation at Executive’s final base salary (annualized salary rate of $450,000) for twelve months from the Resignation Date, such payments to commence on the Company’s next regular payroll date following the Effective Date as defined
below; and (ii) continuation of group plan benefits to the extent authorized by and consistent with 29 U.S.C. § 1161 et seq. (commonly known as “COBRA”), with the cost of the regular premium for such benefits shared in the same
relative proportion by the Company and Executive as in effect on the Resignation Date, until the earlier of (a) twelve months from the Resignation Date, or (b) the date the Executive becomes re-employed or otherwise ineligible for COBRA.
The Parties acknowledge and agree that the severance payments set forth in this Section 3 are the exclusive payments, benefits and rights to 

 
Executive in connection with the ending of Executive’s employment and that Executive is not entitled to any other severance payments or equity rights of any kind pursuant to the Offer Letter
or otherwise. 
 4. General Release. Executive irrevocably and unconditionally releases and forever discharges the Company, and
all of their affiliated and related entities, and their respective predecessors, successors and assigns, its and their respective employee benefit plans and the fiduciaries of such plans, and the current and former officers, directors, stockholders,
employees, attorneys, accountants, and agents of each of the foregoing in their official and personal capacities (collectively referred to as the “Releasees”) generally from all claims, demands, debts, damages and liabilities of every name
and nature, known or unknown (“Claims”) that, as of the date when Executive signs this Agreement, he has, ever had, now claims to have or ever claimed to have had against any or all of the Releasees. This release includes, without
implication of limitation, the complete waiver and release of all Claims of or arising in connection with or for: the Offer Letter including Claims for breach of express or implied contract; fraudulent inducement, wrongful termination of employment
whether in contract or tort; intentional, reckless, or negligent infliction of emotional distress; breach of any express or implied covenant of employment, including the covenant of good faith and fair dealing; interference with contractual or
advantageous relations, whether prospective or existing; deceit or misrepresentation; discrimination or retaliation under state, federal, or municipal law, including, without implication of limitation, Title VII of the Civil Rights Act
of 1964, 42 U.S.C. § 2000e et seq., the Americans with Disabilities Act, 42 U.S.C. § 12101 et seq., the Age Discrimination in Employment Act, 29 U.S.C. § 621 et seq., the Connecticut
Fair Employment Practices Act, Conn. Gen. Stat., Title 46a, Ch. 814c, Sec. 46a-51 et seq., all as amended; all claims arising under any and all other similar federal, state and local statutes, all as amended; and all common law claims including, but
not limited to, actions in tort, defamation, retaliation and breach of contract, all claims to any non-vested ownership interest in the Company (contractual or otherwise), including but not limited to claims to stock or stock options, and any other
claims or damages arising under any other common law theory or any federal, state or local ordinance not expressly referenced above. 
 5.
Equity. The Parties acknowledge and agree that that the Executive was granted options to purchase a portion of the Company’s Ordinary Shares (“Stock Options”) and such Stock Options are governed by the applicable stock
option plans and incentive stock option agreements (collectively “Equity Documents”) which provide, among other things, that no options vested on or prior to the Resignation Date and, therefore, lapsed and are of no further effect.
Executive further acknowledges and agrees that Executive has no enhanced equity rights in connection with the ending of his employment and that, aside from the Stock Options, he has no further equity interests in the Company. 

6. Return of Property. Executive commits to returning to the Company all Company property, including, without limitation, computer
equipment, software, keys and access cards, credit cards, files and any documents (including computerized data and any copies made of any computerized data or software) containing information concerning the Company, its business or its business
relationships. After returning all such property, Executive commits to deleting and finally purging any duplicates of files or documents that may contain Company or customer 

  
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information from any computer or other device that remains Executive’s property after the Resignation Date. 
 7. Nondisparagement; Public Announcement. Executive agrees not to disparage the Company or any of its officers, directors or employees or any of its products or services. Executive hereby
consents to the form of public announcement concerning Executive’s resignation from the Company in substantially the form attached hereto as Appendix A and will not make any written or oral statements that are inconsistent with this
announcement. 
 8. Advice of Counsel. This Agreement is a legally binding document and Executive’s signature will commit
Executive to its terms. Executive acknowledges that he has been advised to discuss all aspects of this Agreement with his attorney, that he has carefully read and fully understands all of the provisions of this Agreement and that Executive is
voluntarily entering into this Agreement. 
 9. Effective Date. To accept this Agreement, Executive must return a signed original
of this Agreement so that it is received by Joseph Zakrzewski, Executive Chairman. This Agreement shall become effective upon execution by the Parties (the “Effective Date”). 
 10. Enforceability. Executive acknowledges that, if any portion or provision of this Agreement shall to any extent be declared illegal or unenforceable by a court of competent jurisdiction,
then the remainder other than those as to which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision shall be valid and enforceable to the fullest extent permitted by law. 

Entire Agreement. This Agreement along with the Equity Documents and the Confidentiality Agreement Executive entered into
with the Company as a condition of being considered for the President and CEO position, and the Deed of Indemnity dated August 16, 2010 and the Employee Confidentiality and Assignment Agreement Executive agreed to enter into as part of the
Offer Letter, the terms of which continue to be in full force and effect and are incorporated by reference into this Agreement, constitute the entire agreement between Executive and the Company concerning Executive’s relationship with the
Company, and supersedes and replaces any and all prior agreements and understandings between the Parties concerning the Executive’s relationship with the Company including, without limitation, the Offer Letter. 

11. Waiver. No waiver of any provision of this Agreement shall be effective unless made in writing and signed by the waiving party. The
failure of either Party to require the performance of any term or obligation of this Agreement, or the waiver by either Party of any breach of this Agreement, shall not prevent any subsequent enforcement of such term or obligation or be deemed a
waiver of any subsequent breach. 
 12. Taxes. The Company shall undertake to make deductions, withholdings and tax reports with
respect to payments and benefits under this Agreement and in connection with other compensation matters to the extent that it reasonably and in good faith determines that it is required to make such deductions, withholdings and tax reports. Payments
under this Agreement shall be in amounts net of any such deductions or withholdings. Nothing in this Agreement shall 

  
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be construed to require the Company to make any payments to compensate Executive for any adverse tax effect associated with any payments or benefits made to Executive in connection with
Executive’s employment with the Company. 
 13. Governing Law; Interpretation. This Agreement shall be interpreted and
enforced under the laws of Connecticut without regard to conflict of law principles. Executive and the Company submit to the exclusive personal jurisdiction of the federal and state courts located in the State of Connecticut in connection with any
dispute or any claim related to this Agreement. In the event of any dispute, this Agreement is intended by the parties to be construed as a whole, to be interpreted in accordance with its fair meaning, and not to be construed strictly for or against
either Party or the “drafter” of all or any portion of this Agreement. 
 14. Counterparts. This Agreement may be
executed in any number of counterparts, each of which when so executed and delivered shall be taken to be an original, but all of which together shall constitute one and the same document. Facsimile and pdf signatures shall be deemed to be of equal
force and effect as originals. 
 [REMAINDER INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, the Parties, intending to be legally bound, have executed this Agreement on the
date(s) indicated below. 
  

							
	AMARIN CORPORATION PLC	 	 	 	 
				
	By:	 	 /s/ Joseph Zakrzewski
	 	 	 	 11/9/2010

		 	Joseph Zakrzewski	 		 	Date
		 	Executive Chairman	 		 	

 I HAVE READ THIS AGREEMENT THOROUGHLY, UNDERSTAND ITS TERMS AND HAVE SIGNED IT KNOWINGLY AND VOLUNTARILY. I
UNDERSTAND THAT THIS AGREEMENT IS A LEGAL DOCUMENT. 
  

					
	 /s/ Colin Stewart
	 		 	 11/9/2010

	Colin Stewart	 		 	Date

  
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 APPENDIX A 
 Amarin Corporation plc announces that its President and Chief Executive Officer, Colin Stewart, has resigned effective November 10, 2010 to address personal matters.Letter Agreement

 Exhibit 10.42 

 

 

 November 15, 2010 
 John F. Thero 
 Mystic, Connecticut 06355 
 Dear John: 
 It is with great pleasure that I confirm your recent promotion to the position of
President of Amarin Corporation plc (the “Company”), effective November 10, 2010. As discussed, it is our expectation that, for the time being, you will also continue to serve as the principal financial officer of the Company as well
as a member of the senior management team of Aramin Pharma Inc. and their affiliates. 
 This letter will serve as an amendment to your
November 5, 2009 letter agreement with the Company regarding the terms and conditions of your employment (the “Letter Agreement”). This letter supplements Section 1 and supersedes Sections 3 and 5 of the Letter Agreement, all
other provision of the Letter Agreement shall remain in full force and effect. 
 In connection with your enhanced role, you will be paid a
bi-weekly salary at the annual rate of $375,000, less applicable deductions and withholdings. Your salary shall be subject to annual review and adjustment at the discretion of the Company. This paragraph supersedes Section 3 of the Letter
Agreement. 
 In addition, you will be eligible to receive an annual performance bonus as determined by the Board (or the Remuneration Committee
thereof) (the “Annual Bonus”). The Company will target the Annual Bonus at 40% of your annual base salary; for purposes of 2010 your Annual Bonus will be pro rated based on the number of days you served as President (at the 40% target
rate) and the number of days you served as Chief Financial Officer (at the 35% target rate in effect prior to your promotion). Any such bonuses shall be payable in the absolute discretion of the Board (or the Remuneration Committee thereof
“REMCO”), taking into account the performance of the Company and your personal performance. Further, any bonus payment will be subject to your employment on the actual payment date of any bonus as well as approval by and adjustment at the
discretion of the Board and the final terms of any applicable bonus plan. This paragraph supersedes Section 5 of the Letter Agreement. 

In connection with your new role, you have been granted options to purchase 1,200,000 Ordinary Shares, par value £0.50 per share (and
represented by American Depository Shares, or ADSs), which represents approximately 1% of the Company’s outstanding equity capitalization based on approximately 102,194,949 Ordinary Shares and options to purchase approximately 11,658,601
Ordinary Shares currently outstanding (excluding warrants). The exercise price per share is the closing price of the Company’s ADSs on the NASDAQ Capital Market on Thursday, November 11, 2010. Twenty five percent (25%) of these option
shares shall be fully vested and immediately exercisable on the date of grant, with the remainder to vest in three equal annual installments, beginning on the first anniversary of November 10, 2010, so long as your employment continues through
such vesting dates. The terms and conditions set forth in the 

 
2002 Stock Option Plan and applicable stock option agreement shall govern any such option award. The paragraph is in addition to and does not supersede any of the provision on the Letter
Agreement. 
 You understand that your employment with the Company will continue to be “at will” which means it is not for a specified
period and may be terminated by either you or the Company at any time subject Section 12 of the Letter Agreement. Similarly, the terms and conditions of your employment may change at the discretion of the Board or REMCO. The Letter Agreement as
amended by this letter supersedes any prior oral or written statements or understanding concerning compensation or other terms of your employment, including statements made by any Board member or Company representative in connection with your
enhanced role. 
 Thank you again for your many contributions to the Amarin over this past year. We look forward to your continued service in
your new role in the years to come. 
  

	
	Very truly yours,
	
	/s/ Joseph S. Zakrzewski
	
	Joseph S. Zakrzewski
	Executive Chairman & CEO

 READ, UNDERSTOOD AND
AGREED: 
  

					
	 /s/ John F. Thero
	 		 	 11/19/2010

	John F. Thero	 		 	Date

  
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