Document:

Exhibit 10.4

                      AGREEMENT AND PLAN OF REORGANIZATION

     This Agreement and Plan of Reorganization ("Agreement") shall be deemed
EFFECTIVE as of the 1st day of June, 2003 (the "Effective Date") by and among
NANOBAC PHARMACEUTICALS INCORPORATED ("Buyer"), a Florida corporation, formerly
known as "AMERICAN ENTERPRISE CORPORATION"; NANOBACLABS PHARMACEUTICAL, INC.
("Nanobac"), a Delaware corporation; and each other person who now or at any
time hereafter has executed a signature page to this Agreement (each being
individually referred to as a "Seller," and any two or more being together
referred to as "Sellers"), each of which is a Nanobac Shareholder (as defined
below). Buyer, Nanobac, and each Seller may be referred to herein as a "Party"
and any two or more of them may be together referred to herein as "Parties." The
fact that a Nanobac Shareholder has not executed the signature page attached for
such Nanobac Shareholder shall not affect the validity, binding effect and
enforceability as to any Nanobac Shareholder who has executed a signature page,
and this Agreement shall be binding upon and enforceable against each Nanobac
Shareholder who has signed a signature page regardless of whether or how many
other Nanobac Shareholders have or have not executed signature pages to this
Agreement.

     Now, therefore, in consideration of the premises and the mutual promises
herein made, and in consideration of the representations, warranties, and
covenants herein contained, the Parties agree as follows.

1. Overview.

     1.1. Background. The only class or series of capital stock of Nanobac of
     which there are shares outstanding consists of shares of Nanobac's Common
     Stock, $.0001 par value per share ("Nanobac Shares"). The persons named on
     Schedule A (the "Nanobac Shareholders") collectively own all currently
     issued and outstanding Nanobac Shares. Buyer desires to acquire all Nanobac
     Shares now or hereafter owned by any Seller during the term of this
     Agreement, and Sellers desire to exchange their Nanobac Shares for shares
     of Buyer's Common Stock, $.001 par value per share ("Buyer Shares").

     1.2. Consideration. Each Seller will exchange such Seller's Nanobac Shares
     solely for Buyer Shares, and will receive no consideration other than Buyer
     Shares, in exchange for such Nanobac Shares.

     IT IS UNDERSTOOD THAT ALL BUYER SHARES OFFERED TO SELLERS PURSUANT THIS
     AGREEMENT ARE NOT REGISTERED UNDER THE SECURITIES ACT OF 1933, AND THAT
     ONLY UN-REGISTERED SHARES ARE BEING OFFERED BY BUYER TO SELLERS UNDER THIS
     AGREEMENT.

     1.3. Reorganization. The transactions contemplated by this Agreement, as a
     whole (the "Reorganization"), will result in the acquisition by Buyer, in
     exchange solely for a part of its voting stock, of all or substantially all
     of the stock of Nanobac; and, immediately after such acquisition. Buyer
     shall have control (within the meaning of Section 368(c) of the Internal
     Revenue Code of 1986, as amended (the "Code")) of Nanobac. Accordingly, the

<PAGE>

     Reorganization is intended to qualify as a reorganization within the
     meaning of Section 368(a)(l)(B) of the Code. It is noted, however, that
     neither Buyer nor Nanobac makes any representation as to the tax treatment,
     consequences or implications of the transactions contemplated hereby, their
     respective legal counsels express no opinion on such matter, and no
     determination or advice on such matter has been or is being obtained or
     requested of the Internal Revenue Service. Further, no obligation of any
     Party is conditioned upon any of the foregoing. The treatment of the
     Reorganization for tax purposes is solely the responsibility of each
     affected Party.

     1.4. Exchanges Prior to Execution. It is acknowledged that one or more
     exchanges of shares, as described in and contemplated by this Agreement,
     occurred on or after the Effective Date but prior to the time the agreement
     of Seller and Buyer with respect thereto was memorialized by the execution
     of this Agreement. Any such exchange shall be deemed to have been and shall
     be treated by the Parties as made on terms described in and pursuant to,
     and shall be subject to, this Agreement. All such prior exchanges, and all
     such exchanges yet to be made, are pursuant to and part of a single
     preconceived ,plan of Buyer to acquire all or substantially all Nanobac
     Shares over a relatively short period of time.

     1.5. Rescission of Letter of Intent. Nanobac, Buyer and one or more of
     Nanobac's principal shareholders (as of prior to the Effective Date)
     previously entered into one or more written and/or oral understandings,
     including but not limited to a letter of intent dated on or about May 29,
     2003 (all such understandings being collectively referred to as the "Letter
     of Intent"). The Parties acknowledge and agree, however, that this
     Agreement, and not the Letter of Intent, accurately reflects the ultimate
     agreement of the Parties. The Letter of Intent has been rescinded and is of
     no force or effect whatsoever.

     1.6. Term and Termination. This Agreement shall be in effect from the
     Effective Date to and including May 31, 2004, whereupon this Agreement
     shall automatically terminate. This Agreement shall not apply to any
     Nanobac Shares or any exchange of shares after such date.

2. Exchange of Stock.

     2.1. No Scheduled Closing; Immediate Exchange. There shall be no scheduled
     closing for any exchange under this Agreement. Rather, promptly upon any
     Seller becoming a party to this Agreement, such Seller shall sell, assign,
     transfer and deliver, to Buyer, a certificate or certificates representing
     all Nanobac Shares then owned by Seller, in each case endorsed in blank or
     accompanied by one or more separate assignments (commonly known as "stock
     powers") executed in blank. For, in consideration of, and with respect to
     each such Nanobac Share, Buyer shall then promptly issue and deliver, to
     such Seller, four Buyer Shares.

     2.2. Future Acquired Nanobac Shares. This Agreement shall apply to any and
     all Nanobac Shares as may be hereafter acquired by any Seller. Accordingly,
     if at any time or from time to time any Seller should acquire or become the
     owner of any Nanobac

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Agreement and Plan of Reorganization                                      Page 2

<PAGE>

     Shares not already subject to Section 2.1, then such Seller thereupon shall
     promptly sell, assign, transfer and deliver, to Buyer, a certificate or
     certificates representing such Nanobac Shares, in each case endorsed in
     blank or accompanied by one or more separate assignments ("stock powers")
     executed in blank. For, in consideration of, and with respect to each such
     Nanobac Share, Buyer shall then promptly issue and deliver, to such Seller,
     four Buyer Shares.

     2.3. Further Assurances. At the time of each exchange of shares pursuant to
     this Agreement ("Exchange") and from time to time thereafter, each Seller
     shall execute such additional instruments and take such other actions as
     Buyer may reasonably request in order more effectively to sell, transfer
     and assign such Seller's Nanobac Shares to Buyer and confirm Buyer's title
     thereto.

     2.4. Changes in Buyer's Capitalization. If between the date of this
     Agreement and any Exchange, the outstanding Buyer Shares are increased,
     decreased, changed into, or exchanged for a different number or kind of
     shares of securities of Buyer through reorganization, reclassification,
     stock dividend, stock split, reverse stock split, or similar change in
     Buyer's capitalization, Buyer will issue and deliver to Sellers, with
     respect to any Exchange occurring thereafter, in addition to or in lieu of
     Buyer Shares referred to above, voting stock of Buyer in equitably adjusted
     amounts. In the event of any such change in Buyer's capitalization, all
     references to Buyer Shares herein shall refer to the number and
     classification of shares so adjusted.

3. Representations and Warranties of Sellers.

     Each Seller represents and warrants to Buyer the following, effective in
each case as of the time such Seller becomes a Party and also at the time of
each Exchange with respect to any Nanobac Shares of such Seller:

     3.1. Ownership of Shares. Such Seller owns the number of Nanobac Shares
     indicated on Schedule A, that such Nanobac Shares have been validly issued
     and are fully paid and are nonassessable; and that such Nanobac Shares are
     owned by such Seller free and clear of any and all liens, security
     interests, claims, liens, encumbrances, restrictions, equities and charges
     whatsoever.

     3.2. Restrictions on Stock. Such Seller is not a party to any agreement,
     written or oral, creating rights in respect of any Nanobac Shares in any
     third person or relating to the voting of any Nanobac Shares.

     3.3. Nanobac Options and Other Securities. Except as indicated on Schedule
     A, Seller does not own or have any interest in, and Seller does not know of
     any ownership or interest of any other person in, any stock, shares,
     warrants, options, stock purchase agreements, redemption agreements,
     restrictions of any nature, calls or rights to subscribe of any character
     relating to Nanobac Shares or any other securities of Nanobac.

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Agreement and Plan of Reorganization                                      Page 3

<PAGE>

     3.4. Organization; Authority Relative to this Agreement. If such Seller is
     a corporation, partnership or other entity, then such Seller is duly
     organized, validly existing and in good standing as such under the laws of
     its jurisdiction of organization, and such Seller has the power and
     authority to enter into and perform its obligations under this Agreement.
     The execution of this Agreement and the delivery of this Agreement by such
     Seller has been duly authorized, this Agreement has been duly and validly
     executed by Seller, and no further other action is necessary to make this
     Agreement valid and binding upon Seller and enforceable against Seller in
     accordance with the terms hereof or to carry out the transactions
     contemplated hereby. The execution, delivery and performance of this
     Agreement by Seller will not (1) constitute a breach or a violation of (if
     applicable) any organizational document of Seller, or of any law, rule or
     regulation, agreement, indenture, deed of trust, mortgage loan agreement or
     other instrument to which such Seller is a party or by which Seller is
     bound; (2) constitute a violation of any order, judgment or decree to which
     such Seller is a party or by which any of the assets or properties of such
     Seller are bound or affected; or (3) result in the creation of any lien,
     charge or encumbrance upon any of the assets or properties of such Seller.

     3.5. Securities Law Matters - Disclosure; Accredited Investor;
     Sophistication; Disclosure; Transfer Restrictions; Etc.

          3.5.1. Such Seller, without regard to any advice provided by any
          investment or other advisor, has the requisite knowledge and
          experience in financial and business matters to have enabled such
          Seller to evaluate the merits and risks of the investment decision
          contemplated by this Agreement.

          3.5.2. Such Seller is familiar with Buyer's and Nanobac's respective
          industries and considers himself/herself to be a sophisticated
          investor with respect to such industries.

          3.5.3. Such Seller acknowledges receipt of all of the information
          concerning Buyer and Nanobac which such Seller considers to be
          material in making the investment decision contemplated by this
          Agreement. Such Seller has had full access to personnel and the books
          and records of Buyer and Nanobac for the purpose of obtaining and
          verifying such information. Such Seller has had a full and fair
          opportunity to meet with officers, directors and other representatives
          of Nanobac and Buyer and to ask questions and receive answers
          regarding the business of Nanobac and Buyer and their respective
          financial condition, results of operations, historical financial
          statements, prospects, risk factors, contingencies and uncertainties
          and any other matters of concern to such Seller or as such Seller has
          felt necessary or appropriate to assist in an evaluation of the merits
          and risks of the investment contemplated by this Agreement. All
          material documents and information pertaining to Nanobac and Buyer and
          the investment therein as may have been requested were made available
          to such Seller. In particular, such Seller has been furnished with or
          obtained copies of Buyer's recent filings with the United States
          Securities and Exchange Commission ("SEC"), and information

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Agreement and Plan of Reorganization                                      Page 4
<PAGE>

          provided to such Seller as an investor in Nanobac, and has read and
          understands the information in such materials.

          3.5.4. No representations or warranties, oral or otherwise, have been
          made to such Seller, including, without limitation, any
          representations concerning the future prospects of Buyer, by any
          person whether or not associated with this transaction. In entering
          into this transaction, such Seller is not relying upon any
          information, other than the information received from Buyer and
          Nanobac, and the results of such Seller's own independent
          investigation. Such Seller has obtained sufficient information to
          evaluate the merits and risks of this investment and to make an
          informed investment decision.

          3.5.5. Such Seller understands that, because Buyer Shares received by
          such Seller will constitute "restricted securities" under federal and
          state securities laws insofar as they have not been registered under
          applicable securities laws, they may not be resold or transferred
          without compliance with the registration or qualification provisions
          of applicable federal and state securities laws or the availability of
          an exemption from such registration and qualification requirements.
          Such Seller has consulted with his or her own legal counsel regarding
          to the restrictions on resale imposed by federal and applicable state
          securities laws on restricted securities. Such Seller is entering into
          the transaction contemplated hereby and acquiring Buyer Shares for
          investment purposes only, and not for resale or subsequent
          distribution, and is not participating in any distribution to the
          public of Buyer Shares. Such Seller understands that each certificate
          representing Buyer Shares will bear an appropriate legend reflecting
          such transfer restrictions.

          3.5.6. Such Seller meets at least one of the suitability standards
          described below:

          o    If such Seller is an individual, such Seller alone, or such
               Seller with his or her spouse, has a net worth (i.e., total
               assets in excess of total liabilities) of at least $1,000,000; or

          o    If such Seller is an individual, such Seller, individually
               (without such Seller's spouse), has had during each of the last
               two years, and such Seller reasonably anticipate that such Seller
               will have during the present and the next year, an individual
               income in excess of $200,000; or

          o    If such Seller is an individual, such Seller and such Seller's
               spouse, together, have had during each of the last two years, and
               reasonably anticipate that they will have during the present and
               the next year, a joint income in excess of $300,000; or

          o    Such Seller is an executive officer or director of Buyer; or

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Agreement and Plan of Reorganization                                      Page 5

<PAGE>

          o    If such Seller is an institutional investor, such Seller
               satisfies one or more of the requirements of Sections
               501(a)(l),(2),(3) or (8) of SEC Regulation D; or

          o    If such Seller is a trust, such Seller have total assets in
               excess of $5,000,000 and this purchase is being directed by a
               person who has such knowledge and experience in financial and
               business matters that such person is capable of evaluating the
               merits and risks of an investment in Buyer Shares; or

          o    If such Seller is a corporation or a partnership, each of such
               Sellers equity owners is an Accredited Investor pursuant to one
               of the prior tests.

     3.6. Loss of Investment. Such Seller understands an investment in Buyer
     Shares involves substantial risks. Such Seller is able to bear the economic
     risk of such investment and could afford the complete loss of such
     investment and, if such Seller is an individual, without impairing such
     Seller's ability to provide for such Seller and such Seller's family in the
     same manner as at the present time.

     3.7. Tax Advice. Such Seller has consulted such Seller's own tax advisor to
     determine the particular federal, state and local tax consequences that may
     result from consummating an Exchange as contemplated hereby.

     3.8. Continuity of Business Enterprise. It is the present intention of
     Buyer to continue at least one significant historic business line of
     Nanobac, or to use at least a significant portion of Nanobac's historic
     business assets in a business, in each case within the meaning of Reg.
     Section 1.368-l(d).

     3.9. Disclosure. No representation or warranty made by such Seller in this
     Agreement contains any untrue statement of a material fact or omits to
     state a material fact necessary to make the statements contained herein not
     misleading.

4. Representations and Warranties of Buyer.

     Buyer represents and warrants to each Seller the following, effective in
each case as of the time such Seller becomes a Party and also at the time of
each Exchange with respect to any Nanobac Shares of such Seller:

     4.1. Organization and Standing. Buyer is a corporation duly organized,
     validly existing and in good standing under the laws of the State of
     Florida and has the corporate power and authority to carry on its business
     as it is now being conducted.

     4.2. Capitalization; Buyer Shares. The entire authorized capital stock of
     Buyer consists of 100,000,000 Buyer Shares, of which 37,650,395 Buyer
     Shares are duly authorized, issued, unregistered and outstanding, and
     62,349,605 Buyer Shares are duly authorized but un-issued. All Buyer Shares
     to be issued pursuant to this Agreement have been duly authorized and, upon
     execution and delivery of certificates therefor to

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Agreement and Plan of Reorganization                                      Page 6
<PAGE>

     Sellers as contemplated by this Agreement, will be validly issued, fully
     paid and nonassessable shares of the Common Stock, $.001 par value per
     share, of Buyer.

     4.3. Authority Relative to this Agreement.

          4.3.1. The execution of this Agreement and the delivery of this
          Agreement by Buyer have been duly authorized by Buyer, this Agreement
          has been duly and validly executed by Buyer, and no further corporate
          or other action is necessary on its part to make this Agreement valid
          and binding upon Buyer and enforceable against Buyer in accordance
          with the terms hereof or to carry out the transactions contemplated
          hereby.

          4.3.2. The execution, delivery and performance of this Agreement by
          Buyer will not (1) constitute a breach or a violation of the Articles
          of Incorporation or by-laws of Buyer or of any law, rule or
          regulation, agreement, indenture, deed of trust, mortgage loan
          agreement or other instrument to which Buyer is a party or by which it
          is bound; (2) constitute a violation of any order, judgment or decree
          to which Buyer is a party or by which any of the assets or properties
          of Buyer are bound or affected; or (3) result in the creation of any
          lien, charge or encumbrance upon any of the assets or properties of
          Buyer.

          4.3.3. No consent, approval or authorization is required to be
          obtained by Buyer in connection with the execution or delivery of this
          Agreement by Buyer or the consummation by Buyer of the transactions
          contemplated hereby except as has been or will have been timely
          obtained prior to Closing.

     4.4. SEC Filings. Each report filed by Buyer during the current calendar
     year with the SEC, when filed, (i) complied with applicable law in all
     material respects, and (ii) did not contain any untrue statement of a
     material fact or omit to state a material fact necessary in order to make
     the statements made therein, in light of the circumstances under which they
     were made, not misleading.

     4.5. Litigation. No proceeding affecting Buyer's ability to consummate the
     Reorganization has been asserted or threatened by any person or is pending
     before any court, mediator, arbitrator, or governmental authority.

     4.6. Compliance with Law. This Agreement complies in all respects with the
     laws of the states of domicile and principal places of business of Buyer.

     4.7. Disclosure. No representation or warranty made by Buyer in this
     Agreement contains or will contain at the Closing any untrue statement of a
     material fact or omits or will omit to state a material fact necessary to
     make the statements contained herein or therein not misleading.

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Agreement and Plan of Reorganization                                      Page 7
<PAGE>

5. Matters Prior or Subsequent to Closing.

     Except as specifically stated otherwise in this Agreement, there are no
matters contemplated to be carried out between any Parties prior to or after any
Exchange.

6. Conditions to the Obligations of the Parties.

     Each Party has conducted all investigations of all matters important to it
prior to entering into this Agreement. Accordingly, the obligations of the
Parties under this Agreement are not subject to or conditioned upon any matter,
occurrence or circumstance.

7. General.

     7.1. No Brokers. Each Party hereby represents and warrants, each to the
     others, that it has not utilized the services of any finder, broker or
     agent in connection with the transactions contemplated hereby, and each
     agrees to indemnify each other Party against and hold each such Party
     harmless from any and all liabilities to any person, firm or corporation,
     claiming any broker's or finder's fee or commission of any kind on account
     of services rendered on behalf of such Party in connection with the
     transactions contemplated by this Agreement.

     7.2. Survival of Representations, Warranties, Etc. Each Party covenants and
     agrees that its representations, warranties, covenants, statements and
     agreements contained in this Agreement shall survive the completion of the
     Reorganization.

     7.3. Waivers. No action taken pursuant to this Agreement, including any
     investigation by or on behalf of any Party, shall be deemed to constitute a
     waiver by the Party taking such action of compliance with any
     representation, warranty, covenant or agreement contained in this
     Agreement. The waiver by any Party of a breach of any provision of this
     Agreement shall not operate or be construed as a waiver of any subsequent
     breach.

     7.4. Remedies. Each Party acknowledges that the performance of such Party's
     respective obligations hereunder is essential to the consummation of the
     transactions contemplated by this Agreement. Each of them further
     acknowledges that the Nanobac Shares are unique and that no Party will have
     an adequate remedy at law if any other Party fails to perform its or his
     obligations hereunder. In such event, each Party shall have the right, in
     addition to any other rights it may have, to compel specific performance of
     this Agreement.

     7.5. Expenses. Each Party shall pay its own expenses in connection with
     this Agreement and the transactions contemplated hereby, including the fees
     and expenses of its counsel and its certified public accountants and other
     experts. Cash expenses of Sellers incurred in connection with the execution
     of this Agreement and the consummation of the transactions contemplated
     hereby are to be liabilities borne by Sellers individually and will not be
     paid by Nanobac or assumed by Buyer pursuant to this Agreement.

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Agreement and Plan of Reorganization                                      Page 8

<PAGE>

     7.6. Entire Agreement; Amendment. This Agreement (including the Exhibits
     hereto) constitutes the entire agreement, and supersedes all prior
     agreements and understandings, oral and written, among the Parties with
     respect to the subject matter hereof. This Agreement may be amended only by
     written agreement executed by all of the Parties.

     7.7. Assignability. This Agreement shall not be assignable by any Party
     without the prior written consent of all other Parties.

     7.8. Further Assurances. Each Party shall execute and deliver, or cause to
     be executed and delivered, such additional or further transfers,
     assignments, endorsements or other instruments as any other Party or its
     counsel may reasonably requests for the purpose of carrying out the
     transactions contemplated by this Agreement.

     7.9. Counterparts. This Agreement may be executed in two or more
     counterparts, each of which shall be deemed an original, but all of which
     together shall constitute one and the same instrument.

     7.10. Section and Other Headings. The section and other headings contained
     in this Agreement are for purposes of reference only and shall not affect
     the meaning or interpretation of this Agreement.

     7.11. Governing Law. The validity, construction and enforcement of, and the
     remedies under, this Agreement shall be governed in accordance with the
     laws of the State of Florida (except that if any choice of law provision
     under Florida law would result in the application of the law of a state or
     jurisdiction other than the State of Florida, such provision shall not
     apply).

     IN WITNESS WHEREOF, this Agreement has been signed by each of the
individual Parties hereto and signed by an officer thereunto duly authorized and
attested under the corporate seal by the Secretary or Assistant Secretary of
each of the corporate Parties hereto, in each case as of the respective dates
indicated by each signature below.

[Remainder of this page intentionally left blank. Signatures appear following
Schedule A.]

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Agreement and Plan of Reorganization                                      Page 9
<PAGE>
<TABLE>
<CAPTION>

                                            Schedule A
                                                to
                               Agreement and Plan of Reorganization

Name of Investor                                      Number of Common Shares                   Options
-----------------                                     -----------------------                  -------

<S>                                                        <C>
Gary S. Mezo                                               3,660,000.00
Nancy M. Schriewer-Mezo                                    2,340,000.00

Seth P. Slocum, Jr.                                         450000.00
E. Olavi Kajander                                           150000.00
Benedict Maniscalco                                         100000.00
Kenneth L. Schriewer                                         40000.00
J. Michael Otwell                                            40000.00
Robert K. Parker                                             40000.00
Karen A. Taylor                                              40000.00

Richard Berger / Kevin Coy - j/t                            50,000.00
Frank & Colleen Adamek, joint tenants                       50,000.00
      With rights of survivorship
Andrew J. Adams & Elizabeth M. Adams,                       50,000.00
      Joint tenants with rights of Survivorship
Ralph & Colleen Bennett                                     50,000.00
Richard D. Cassidy                                          50,000.00
Comfort Scan, Inc.                                          52,000.00
David Hyman, as Trustee of the                              200,000.00
      David Hyman Trust
Benedict Maniscalco and Albert Salem,                       50,000.00
      Tenants in Common
Edward W. McGuinness, as Trustee of the                     100,000.00
      Edward W. McGuinness Trust UID,
      Dated June 2, 1989
James S. Mulkey                                             82,500.00
Steven Silvers and Joy Silvers, joint                       55,000.00
      Tenants with rights of survivorship
CCOS Florida Limited LLLP                                   110,000.00                       125,000.00
J. Robert Sierra, Inc.                                      330,000.00                       375,000.00
                                                            ----------                       ----------

Totals                                                     8,089,500.00                      500,000.00
</TABLE>

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Agreement and Plan of Reorganization                                     Page 10
<PAGE>

Signature Page to Agreement and Plan of Reorganization Effective as June 1,
2003:

NANOBAC PHARMACEUTICALS INCORPORATED ("Buyer"),
a Florida corporation formerly known as
"AMERICAN ENTERPRISE CORPORATION"

/s/ John Stanton
Name:  John Stanton
Title: President
Date Signed: July 11, 2003

NANOBACLABS PHARMACEUTICAL, INC. ("Nanobac")

/s/ Seth Slocum, Jr.
Name: Seth Slocum, Jr.
Title: President / CEO
Date Signed: July 11, 2003

[Remainder of this page intentionally left blank. Signatures of Sellers follow
on separate pages.]

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Agreement and Plan of Reorganization                                     Page 11
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Gary S. Mezo
         Seller's Name:  Gary S. Mezo
         Date Signed: June 1, 2003
                      ------------

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Agreement and Plan of Reorganization                                     Page 12
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Nancy M. Schriewer-Mezo
         Seller's Name:  Nancy M. Schriewer-Mezo
         Date Signed: June 1, 2003
                      ------------

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Agreement and Plan of Reorganization                                     Page 13
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Seth P. Slocum, Jr.
         Seller's Name:  Seth P. Slocum, Jr.
         Date Signed: June 16, 2003
                      -------------

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Agreement and Plan of Reorganization                                     Page 14

<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ E. Olavi Kajander
         Seller's Name:  E. Olavi Kajander
         Date Signed: July 18, 2003
                      -------------

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Agreement and Plan of Reorganization                                     Page 15
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Benedict Maniscalco
         Seller's Name:  Benedict Maniscalco
         Date Signed: July 29, 2003
                      -------------

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Agreement and Plan of Reorganization                                     Page 16
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Kenneth L. Schriewer
         Seller's Name:  Kenneth L. Schriewer
         Date Signed: July 17, 2003
                      -------------

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Agreement and Plan of Reorganization                                     Page 17
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ J. Michael Otwell
         Seller's Name:  J. Michael Otwell
         Date Signed: July 15, 2003

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Agreement and Plan of Reorganization                                     Page 18
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Robert K. Parker
         Seller's Name:  Robert K. Parker
         Date Signed: July 22, 2003
                      -------------

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Agreement and Plan of Reorganization                                     Page 19

<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Karen A. Taylor
         Seller's Name:  Karen A. Taylor
         Date Signed: July 21, 2003
                      -------------

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Agreement and Plan of Reorganization                                     Page 20
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Richard Berger
         Seller's Name:  Richard Berger
         Date Signed: July 25, 2003
                      -------------

         /s/ Kevin Coy
         Seller's Name:  Kevin Coy
         Date Signed: July 23, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 21

<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Frank Adamek
         Seller's Name:  Frank Adamek
         Date Signed: July 18, 2003
                      -------------

         /s/ Colleen Adamek
         Seller's Name:  Colleen Adamek
         Date Signed: July 18, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 22
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Andrew J. Adams
         Seller's Name:  Andrew J. Adams
         Date Signed: July 23, 2003
                      -------------

         /s/ Elizabeth M. Adams
         Seller's Name:  Elizabeth M. Adams
         Date Signed: July 23, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 23
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Ralph Bennett
         Seller's Name:  Ralph Bennett
         Date Signed: July 18, 2003
                      -------------

         /s/ Colleen Bennett
         Seller's Name:  Colleen Bennett
         Date Signed: July 17, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 24
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Richard D. Cassidy
         Seller's Name:  Richard D. Cassidy
         Date Signed: July 16, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 25
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Ronald Hagstrom
         Seller's Name:  Comfort Scan, Inc.
         Signer's Name: Ronald Hagstrom
         Signer's Title: President
         Date Signed: July 17, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 26
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ David Hyman
         Seller's Name:  David Hyman
         Date Signed: July 18, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 27
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         NO SIGNATURE
         Seller's Name:  Benedict Maniscalco
         Date Signed: _______________

         /s/ Albert Salem
         Seller's Name:  Albert Salem
         Date Signed: (not dated)
                      -----------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 28
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Edward McGuinness
         Seller's Name:  Edward McGuinness
         Date Signed: July 16, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 29
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ James S. Mulkey
         Seller's Name:  James S. Mulkey
         Date Signed: July 21, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 30
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Steven Silvers
         Seller's Name:  Steven Silvers
         Date Signed: July 18, 2003
                      -------------

         /s/ Joy Silvers
         Seller's Name:  Joy Silvers
         Date Signed: July 18, 2003
                      -------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 31
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Stuart Sierra
         Seller's Name:  Arries Inc General Partners, CCOS Florida Limited LLLP
                        (a Florida limited liability limited partnership)
         Signer's Name: Stuart Sierra
         Signer's Title: Vice President
         Date Signed: October 27, 2003
                      ----------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 32
<PAGE>

         Signature Page to Agreement and Plan of Reorganization
         Effective as June 1, 2003:

         /s/ Stuart Sierra
         Seller's Name:  J. Robert Sierra, Inc.
                         (a Florida corporation)
         Signer's Name: Stuart Sierra
         Signer's Title: Vice President
         Date Signed: October 27, 2003
                      ----------------

--------------------------------------------------------------------------------
Agreement and Plan of Reorganization                                     Page 33Exhibit 10.10

                                 PROMISSORY NOTE

                           NANOBAC PHARMACEUTICALS INC

$2,233,668                                                     December 31, 2003
5%                                                             Tampa, Florida

1.   Promise to Pay. NANOBAC PHARMACEUTICALS INC a Florida Corporation
     ("Borrower"), for value received promises to pay to the order of Escape
     Velocity, Inc. ("Lender"), the principal amount of TWO MILLION TWO HUNDRED
     THRITY-THREE THOUSAND SIX HUNDRED SIXTY-EIGHT U.S. DOLLARS (U.S.
     $2,233,668) on demand.

2.   Addiitons to Principal. From time to time, Borrower may advance additional
     funds to Lendor. Such additional advances shall be covered by the terms of
     this note.

3.   Interest. Interest shall be payable at five percent (5%) per annum
     compounded annually and added to the principal balance of the note.

4.   Default; Remedies; Payment of Costs. The dissolution, insolvency,
     appointment of a custodian, trustee, or receiver for the Borrower, the
     Borrower files (or any creditor files against the Borrower) a petition
     seeking relief under any bankruptcy, insolvency, reorganization, or other
     debtor relief law, or the Borrower dies shall be considered a Default.

     On the occurrence of a "Default" and at any time thereafter Lender, at its
     option and as often as it desires, may declare the full principal amount of
     this Note to be immediately due and payable without demand, notice, or
     presentment.

     Borrower shall pay all costs associated with Lendor's collection of this in
     case of Default or non-payment upon demand.

<PAGE>

5.   Waiver and Consents. Borrower and every person liable at any time for
     payment of this Note waives presentment, protest, notice of protest, and
     notice of dishonor. Borrower expressly consents to all extensions and
     renewals of this Note (as a whole or in part) and all delays in time of
     payment or other performance under this Note that the holder of this Note
     grants at any time and from time to time, without limitation and without
     any notice to or further consent of Borrower. Borrower agrees that its
     obligation under the Note are independent of the obligations of any other
     person or entity that now or later is obligated to pay this Note. Borrower
     also agrees that Lender may release any security for or other obligor of
     this Note or waive, extend, alter, amend, or modify the Note or otherwise
     take any action that varies the risk of Borrower without releasing or
     discharging Borrower form its obligation to repay this Note.

6.   Venue and Waiver of Jury Trial. Borrower further agrees that venue for each
     action, suit, or other legal proceeding arising under or relating to this
     Note or any agreement securing or related to this Note shall be in Tampa,
     Florida. Borrower and Lender knowingly, voluntarily, and intentionally
     waive all rights to a jury trial in any lawsuit, proceeding, counterclaim,
     or other litigation arising under or relating to this Note or any agreement
     securing or relating to this Note. Borrower and Lender have fully discussed
     this provision and agree that this waiver is subject to no exception and
     was a material inducement for Lender to make the loan to Borrower that is
     evidenced by this Note.

7.   Miscellaneous. The headings preceding the text of the sections of this Note
     have been inserted solely for convenience of reference and do not limit or
     affect the meaning, interpretation, or effect of this Note. The validity,
     construction, interpretation, and enforceability of this Note are governed
     by the laws of the State of Florida, excluding its laws relating to the
     resolution of conflicts of laws of different jurisdictions.

EXECUTED: December 31, 2003, in Tampa, Florida

                                          By: /s/ Alexander H. Edwards III
                                          --------------------------------
                                          Alexander H. Edwards III
                                          For Nanobac Pharmaceuticals Inc

                                       2

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