Document:

FOURTEENTH AMENDMENT
                              --------------------

         This Fourteenth Amendment to Lease (this "FOURTEENTH AMENDMENT") is
made as of June 20, 2000, by and between HUB PROPERTIES TRUST, a Maryland real
estate investment trust ("LANDLORD"), and CORVAS INTERNATIONAL, INC., a Delaware
corporation ("TENANT").

                                   WITNESSETH:

         WHEREAS, Hartford Accident and Indemnity Company (the "ORIGINAL
LANDLORD") and Corvas, Inc. (the "ORIGINAL TENANT") entered into a certain lease
dated March 28, 1989 of a portion of the premises located at 3030 Science Park
Road, San Diego, California (the "PROPERTY"), as amended by certain Lease
Amendments dated March 23, 1990 and May 18, 1990; and

         WHEREAS, Corvas International, Inc., a California corporation
("CORVAS") succeeded to the interests of Original Tenant under the lease as set
forth in Consent to Assignment of Lease dated March 13, 1991; and

         WHEREAS, Original Landlord and Corvas entered into a Third Lease
Amendment dated May 16, 1991; Fourth Lease Amendment dated January 21, 1992;
Fifth Lease Amendment dated April 15, 1992; Sixth Lease Amendment dated July 16,
1992; and Seventh Lease Amendment dated January 18, 1993; and

         WHEREAS, Tenant succeeded to the interest of Corvas as set forth in
Consent to Assignment of Lease dated September 14, 1993; and

         WHEREAS, Talcott Realty I Limited Partnership succeeded to the interest
of Original Landlord; and

         WHEREAS, Talcott and Tenant entered into an Eighth Lease Amendment
dated July 7, 1995 and a Ninth Lease Amendment dated March 15, 1996; and

          WHEREAS, Landlord has succeeded to the interests of Talcott as set
 forth in Assignment and Assumption of Leases, Contracts and Other Property
 Interests dated December 5, 1996; and

         WHEREAS, Landlord and Tenant entered into a Tenth Amendment to Lease
dated May 12, 1997; Eleventh Amendment to Lease dated April 23, 1998; Twelfth
Amendment to Lease dated March 9, 1999; and Thirteenth Amendment to Lease dated
June 15, 1999; and

         WHEREAS, for purposes of this Fourteenth Amendment, the
above-referenced lease dated March 28, 1989 as amended on March 23, 1990; May
18, 1990; May 16, 1991; January 21, 1992; April 15, 1992; July 16, 1992; January
18, 1993; July 7, 1995; March 15, 1996; May 12, 1997; April 23, 1998; March 9,
1999 and June 15, 1999 shall be hereinafter defined collectively as "the LEASE";
and

<PAGE>

         WHEREAS, Tenant desires to increase the size of the Premises by an
additional 10,929 rentable square feet and Landlord is willing to agree to such
expansion subject to and upon the terms and conditions hereinafter provided;

         NOW, THEREFORE, in consideration of the foregoing and for other
consideration, the receipt and sufficiency of which are hereby mutually
acknowledged, Landlord and Tenant agree that the Lease is hereby amended as
follows:

         1. The definition of "PREMISES" as set forth in Section 1(a) of the
Eighth Lease Amendment and Section 1 of the Thirteenth Lease Amendment shall be
deleted and the following shall be inserted in its place: "The Premises shall be
deemed to consist of 31,332 rentable square feet of area (the "EXISTING SPACE")
and, commencing on the Suite 202 Commencement Date (as hereinafter defined) and
terminating on September 30, 2006, the Existing Space plus 10,929 rentable
square feet of area ("SUITE 202") From October 1, 2006 until October 31, 2006,
the Premises shall consist of Suite 202 only".

         2. The definition of "BASE RENT" set forth in Section 2 of the
Thirteenth Lease Amendment shall be amended by deleting all rent set forth in
the Thirteenth Lease Amendment from the date 10/01/99 and thereafter and
inserting the following in its place:

<TABLE>
<CAPTION>
                              Base Rent for the                  Base Rent for                Total Base
 Lease Period                 Existing Space Per Annum           Suite 202 Per Annum          Rent Per Annum
 ------------                 ------------------------           -------------------          --------------
 <S>                          <C>                                <C>                          <C>
 "10/01/99 to 06/30/00:       $ 883,562.40                       $0.00                        $ 883,562.40
  07/01/00 to 09/30/00:       $ 883,562.40                       $ 327,870.00                 $1,211,432.40
  10/01/00 to 09/30/01:       $ 914,487.08                       $ 327,870.00                 $1,242,357.08
  10/01/01 to 09/30/02:       $ 946,494.03                       $ 339,345.45                 $1,285,839.48
  10/01/02 to 09/30/03:       $ 979,621.43                       $ 351,222.54                 $1,330,843.97
  10/01/03 to 09/30/04:       $1,013,908.18                      $ 363,515.33                 $1,377,423.51
  10/01/04 to 09/30/05:       $1,049,394.96                      $ 376,238.37                 $1,425,633.33
  10/01/05 to 09/30/06:       $1,086,123.79                      $ 389,406.71                 $1,475,530.50
  10/01/06 to 10/31/06:       $0.00                              $ 403,035.94                 $ 403,035.94"

</TABLE>

         3. The definition of "MONTHLY INSTALLMENTS OF BASE RENT" set forth in
Section 3 of the Thirteenth Lease Amendment shall be amended by deleting all
rent set forth in the Thirteenth Lease Amendment from the date 10/01/99 and
thereafter and inserting the following in its place:

<TABLE>
<CAPTION>
                              Base Rent for the                  Base Rent for                Total Base
 Lease Period                 Existing Space Per Month           Suite 202 Per Month          Rent Per Month
 ------------                 ------------------------           -------------------          --------------
 <S>                          <C>                                <C>                          <C>
 "10/01/99 to 06/30/00:       $ 73,630.20                        $0.00                        $ 73,630.20
  07/01/00 to 09/30/00:       $ 73,630.20                        $27,322.50                   $ 100,952.70
  10/01/00 to 09/30/01:       $ 76,207.26                        $27,322.50                   $ 103,529.76
  10/01/01 to 09/30/02:       $ 78,874.51                        $28,278.79                   $ 107,153.30
  10/01/02 to 09/30/03:       $ 81,635.12                        $29,268.55                   $ 110,903.67
  10/01/03 to 09/30/04:       $ 84,492.35                        $30,292.94                   $ 114,785.29
  10/01/04 to 09/30/05:       $ 87,449.58                        $31,353.20                   $ 118,802.78
  10/01/05 to 09/30/06:       $ 90,510.32                        $32,450.56                   $ 122,960.88
  10/01/06 to 10/31/06:       $ 0.00                             $33,586.33                   $ 33,586.33"

</TABLE>

                                      -2-
<PAGE>

         4. Section 4 of the Thirteenth Lease Amendment shall be amended by
deleting all amounts listed from the date 10/01/99 and thereafter and inserting
the following in its place:

<TABLE>
<CAPTION>

 Lease Period                              Per Sq. Ft. Rate
 ------------                              ----------------
 <S>                                       <C>
 "10/01/99 to 06/30/00:                    $28.20 as to the Existing Space
  07/01/00 to 09/30/00:                    $28.20 as to the Existing Space plus $30.00 as to Suite 202
  10/01/00 to 09/30/01:                    $29.19 as to the Existing Space plus $30.00 as to Suite 202
  10/01/01 to 09/30/02:                    $30.21 as to the Existing Space plus $31.05 as to Suite 202
  10/01/02 to 09/30/03:                    $31.27 as to the Existing Space plus $32.14 as to Suite 202
  10/01/03 to 09/30/04:                    $32.36 as to the Existing Space plus $33.26 as to Suite 202
  10/01/04 to 09/30/05:                    $33.49 as to the Existing Space plus $34.43 as to Suite 202
  10/01/05 to 09/30/06:                    $34.67 as to the Existing Space plus $35.63 as to Suite 202
  10/01/06 to 10/31/06:                    $36.88 as to Suite 202"

</TABLE>

         5. Section II.D of the Lease shall be amended by inserting the
following definition:

         "SUITE 202 COMMENCEMENT Date. The Suite 202 Commencement Date shall be
July 1, 2000. Landlord shall deliver and Tenant shall accept Suite 202 in "as
is" condition. Landlord shall have no responsibility to make any improvements to
Suite 202. Tenant shall, at its sole cost and expense, have plans ("TENANT'S
PLANS") prepared for any improvements to Suite 202, and shall submit Tenant's
Plans to Landlord for its approval (which approval shall not be unreasonably
withheld or delayed). Any disapproval shall be accompanied by a specific
statement of reasons therefor and Tenant shall promptly revise and resubmit such
Plans in order to obtain Landlord's approval thereof. After approval of Tenant's
Plans, Tenant shall complete the work, at its sole cost and expense, as
specified therein".

         6. The definition of "TERMINATION DATE" as set forth in Section II.E of
the Lease shall be amended by deleting the date "September 30, 2006" therefrom
and inserting the following in its place: "September 30, 2006 as to the Existing
Space and October 31, 2006 as to Suite 202."

         7. The definition of "TENANT'S PROPORTIONATE SHARE" as set forth in
Section 1( c) of the Eighth Lease Amendment shall be amended by deleting the
percent of 38.77 therefrom and inserting the percent of 54.298 in its place. As
of the Termination Date of the Existing Space, Tenant's Proportionate Share
shall be reduced to be 14.04%.

         8. As of the Suite 202 Commencement Date, Section 6 of the Thirteenth
Lease Amendment shall be amended to reflect the total number of unreserved
Parking Spaces to be 136 spaces. As of the Termination Date of the Existing
Space, the total number of unreserved Parking Spaces shall be reduced to be 31
spaces.

         9. Section 7 of the Thirteenth Amendment to Lease shall be amended to
reflect that Tenant shall increase the Security Deposit, for the period
commencing July 1, 2000 and thereafter for the remainder of the term, and
deliver to Landlord a fourth clean irrevocable Letter of Credit (the "JULY 2000
LETTER OF CREDIT") in the amount of $81,967.50, in a form acceptable to

                                      -3-
<PAGE>

Landlord upon the terms and conditions set forth in the second paragraph of
Section 7 of the Thirteenth Amendment to Lease. The July 2000 Letter of Credit
together with the June 1 Letter of Credit and the October 1 Letter of Credit are
hereinafter collectively referred to as the "LLC".

         10. The definition of "LANDLORD'S MAILING ADDRESS" set forth in Section
4 of the Tenth Lease Amendment shall be deleted in its entirety and the
following inserted in its place: "Hub Properties Trust, 400 Centre Street,
Newton, Massachusetts 02458, Attention: Jennifer B. Clark, with a copy to REIT
Management and Research, Inc., 5627 Oberlin Drive, Suite 112, San Diego,
California 92121, Attention: Lynn E. Schemmel and a copy to Sullivan & Worcester
LLP, One Post Office Square, Boston, Massachusetts 02109, Attention: Warren M.
Heilbronner, Esq.

         11. Tenant warrants and represents that it has dealt with no broker
other than Colliers International ("COLLIERS") in connection with the execution
of this Fourteenth Amendment. Landlord shall pay a brokerage commission to
Colliers pursuant to a separate agreement between Landlord and Colliers. Tenant
agrees to indemnify and hold Landlord harmless from and against any and all
brokerage claims, other than the amounts to be paid by Landlord as provided in
the foregoing sentence.

         12. All capitalized terms used herein without definition shall have the
meaning ascribed to them by the Lease.

         13. Tenant, its successors and assigns, shall not assert nor seek to
enforce any claim for breach of the Lease (as amended hereby) against any of
Landlord's assets other than Landlord's interest in the Property, and Tenant
agrees to look solely to such interest for the satisfaction of any liability or
claim against Landlord under the Lease (as so amended), it being specifically
agreed that in no event whatsoever shall Landlord ever be personally liable for
any such liability. Tenant further acknowledges that the Declaration of Trust of
HUB Properties Trust provides, and Tenant agrees, that no trustee, officer,
director, general or limited partner, member, shareholder, beneficiary, employee
or agent (including any person or entity from time to time engaged to supervise
and/or manage the operation of Landlord) shall be held to any liability, jointly
or severally, for any debt, claim, demand, judgment, decree, liability or
obligation of any kind (in tort, contract or otherwise) of, against or with
respect to Landlord or arising out of any action taken or omitted for or on
behalf of Landlord.

         14. As amended hereby, the Lease is hereby ratified and confirmed.

                                      -4-
<PAGE>

         IN WITNESS WHEREOF, the parties have hereto executed this Fourteenth
Amendment as of the date first written above.

                                          LANDLORD:

                                          HUB PROPERTIES TRUST, a Maryland real
                                          estate investment trust

                                          By:  /S/ JENNIFER B. CLARK
                                               ---------------------
                                               Name:
                                               Its:

                                          TENANT:

                                          CORVAS INTERNATIONAL, INC., a Delaware
                                          corporation

                                          By:  /S/ RANDALL E. WOODS
                                               --------------------
                                               Name: Randall E. Woods
                                               Its: President & CEO

                                      -5-***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                             UNDER 17 C.F.R. SS.SS. 22.80(b)(4),
                                                               200.83 AND 240b-2

                                    AGREEMENT

This Agreement is by and between Centocor, Inc. ("CENTOCOR"), having a business
address of 200 Great Valley Parkway, Malvern, PA 19355-1307, and Corvas
International, Inc. ("CORVAS"), having a business address of 3030 Science Park
Road, San Diego, CA 92121.

WHEREAS, pursuant to a September 14, 1990 letter agreement and a November 7,
1991 letter agreement, CENTOCOR and CORVAS agreed to jointly develop a
pharmaceutical product based on an antibody designated Corsevin M; and

WHEREAS, CENTOCOR notified CORVAS, by letter dated November 20, 1991, that
CENTOCOR wished to obtain an exclusive license to Corsevin M; and

WHEREAS, the parties did not negotiate or enter into a license agreement
directed to Corsevin M; and

WHEREAS, CENTOCOR, by letter dated August 10, 1994, notified CORVAS that
CENTOCOR was terminating its efforts to develop Corsevin M; and

WHEREAS CORVAS now desires to obtain materials and information related to
CENTOCOR's efforts to develop Corsevin M;

NOW, THEREFORE, the parties agree as follows:

1.       CORVAS agrees that during the period September 14, 1990 through August
         10, 1994, CENTOCOR diligently worked to develop a pharmaceutical
         product based on Corsevin M, and hereby waives any right to bring or
         prosecute any legal action against CENTOCOR in connection therewith.

<PAGE>

2.       The parties agree that effective August 10, 1994, any obligations to
         develop Corsevin M by CENTOCOR ceased, and CENTOCOR ceased to have any
         right or license from CORVAS to commercialize Corsevin M.

3.       CENTOCOR agrees to return to CORVAS all materials and documents which
         CORVAS originally transferred to CENTOCOR, including the murine cell
         line designated 12D10.

4.       CENTOCOR agrees to provide CORVAS with information and materials
         related to Corsevin M which were developed by CENTOCOR, including the
         chimeric 12D10 cell line and purified Fab fragment of chimeric 12D10
         antibody.

5.       In consideration of CENTOCOR's diligent efforts to develop Corsevin M,
         and the materials CENTOCOR agrees to provide CORVAS under Paragraphs 3
         and 4 above, CORVAS agrees to pay CENTOCOR the following:

         a)       [...***...] of sales invoiced to end users by CORVAS, an
                  affiliate of CORVAS, or any licensee or distributor acting on
                  CORVAS' behalf, of any product based on Corsevin M; and

         b)       [...***...] of all fees received by CORVAS from a licensee or
                  distributor for any product based on Corsevin M until a
                  cumulative total of [...***...] has been paid to Centocor.
                  Payment is to be made to Centocor with fifteen (15) days
                  following CORVAS' receipt.

AGREED AND ACCEPTED

CENTOCOR, INC.                                       CORVAS INTERNATIONAL, INC.

By:     /S/ JOSEPH C. SCODARI                        By: /S/ RANDALL E. WOODS
        ---------------------------                      --------------------

Title:  PRESIDENT                                    Title: PRESIDENT AND CEO
        ---------------------------                         -----------------

Date:   7/12/00                                      Date: JULY 14, 2000
        ---------------------------                        ------------------

*CONFIDENTIAL TREATMENT REQUESTED

                                       -2-

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