Document:

Exhibit 10.15 (b)

EXHIBIT A

AMENDED AND RESTATED SENIOR SECURED PROMISSORY NOTE

Cambridge, Massachusetts

	
  $7,000,000

  	
  As of
  May 31, 2002

  

 

FOR VALUE RECEIVED,  DYAX
CORP., a Delaware corporation (the “Debtor”), hereby promises to pay to
the order of GENZYME CORPORATION, a Massachusetts corporation (the “Lender”),
the principal amount of SEVEN MILLION DOLLARS ($7,000,000), together with
interest on the unpaid principal balance of this Note from time to time
outstanding at a variable rate per annum equal to the sum of: (a) the Prime
Rate in effect from time to time and (b) two percent (2%) (the “Basic Rate”).  Each change in such interest rate shall take
effect simultaneously with the corresponding change in such Prime Rate.  “Prime Rate” shall mean the rate of interest
published in the Wall Street Journal as the prime
rate from time to time.  All interest
accrued hereunder shall be due and payable quarterly in arrears on the first
business day of each calendar quarter, commencing on the first such date to
occur at least thirty (30) days after the date of the first advance.  The outstanding principal sum hereunder,
together with any accrued but unpaid interest and all other charges payable
hereunder, shall be due and payable in full on May 31, 2010 (the “Maturity
Date”), unless accelerated or subject to mandatory prepayment as provided
below.

Upon the occurrence of an Event of Default (as
defined below), the entire unpaid principal balance of this Note, together with
any interest accrued thereon and all other sums due or owed by the Debtor
hereunder, shall at the option of the Lender, upon notice from Lender (except
for an Event of Default under of Section 4(e) or Section 4(f) hereof which will
be without notice) to the Debtor become immediately due and payable with
interest (after such Event of Default and until the Debtor’s indebtedness to
the Lender is paid in full).  Interest on
such amounts shall accrue and be payable at a rate per annum equal to the sum
of:  (a) the sum of the Basic Interest
Rate then in effect and (b) three percent (3%).

All payments of principal, interest and other amounts
payable on or in respect of this Note shall be made to the Lender at its office
at 500 Kendall Street, Cambridge, Massachusetts 02142, or to such other place
as the Lender may from time to time direct, in lawful money of the United
States of America, in funds immediately available.  Interest shall be computed on the basis of a
360-day year and a 30-day month.

It is the intent of the Lender and the Debtor that in
no event shall interest be payable at a rate in excess of the maximum rate
permitted by applicable law (the “Maximum Legal Rate”).  Solely to the extent necessary to prevent
interest under this Note from exceeding the Maximum Legal Rate, any amount that
would be treated as excessive under a final judicial interpretation of
applicable law shall be deemed to have been a mistake and automatically
cancelled and, if received by the Lender, shall be applied to the principal
balance of this Note or, if no principal balance remains outstanding, then such
amount shall be refunded to the Debtor.

1.             Collateral

This Note is secured by that certain letter of credit
issued by Silicon Valley Bank, a copy of which is attached hereto as Exhibit
A (the “Letter of Credit”) and incorporates by reference the
provisions thereof.  Neither the
foregoing reference to the Letter of Credit nor any provisions thereof shall
affect or impair the absolute and unconditional obligation of the Debtor to pay
the principal, interest and all other charges payable hereunder on this Note as
provided herein.

2.             [Intentionally
omitted.]

EXHIBIT A

3.             Prepayment of Principal

The Debtor may, at its option, prepay from time to
time all or any part of this Note without premium or penalty but together with
interest on the principal amount so prepaid accrued to the date of prepayment.

4.             Events of Default

Upon the occurrence of any one or more of the
following events (each, an “Event of Default”), the Lender at its option
may declare all amounts due hereunder, including, without limitation, the
entire unpaid principal balance of this Note and any accrued, unpaid interest
thereon, to be immediately due and payable without notice or protest (both of
which are hereby waived):

(a)           The failure to make any payment of interest within 5
business days of the due date thereof (without reference to Section 6.3 below),
or failure to make payment of principal or other amounts due pursuant to the
terms of this Note on or before the due date;

(b)           A judgment, decree, writ, warrant of attachment or similar
process in an amount equal to or exceeding $1,000,000 is entered against the
Debtor or any of its assets, if such judgment, decree, writ, warrant of
attachment or similar process is not adequately covered by insurance or has not
been vacated, discharged, appealed from (with execution or similar process
continuously stayed) within thirty (30) days of such judgment’s entry;

(c)           The occurrence of any event that permits any indebtedness
(including a capitalized lease obligation) of the Debtor equal to or exceeding
$100,000 which is owed to a person or entity other than the Lender to be
accelerated, notwithstanding that such acceleration has not taken place;

(d)           A termination of the Amended and Restated Collaboration
Agreement dated as of May 31, 2002, between the Debtor and the Lender, as
amended to date (the “Collaboration Agreement”) by (i) either party pursuant to
Sections 13.2.3 or 13.2.4, (ii) the Debtor pursuant to Section 13.2.2, (iii)
the Lender pursuant to Section 13.2.1 or (iv) either party pursuant to Section
13.2.5 and the Debtor does not exercise its license option
pursuant to Section 13.3.5(a) of the Collaboration Agreement;

(e)           A proceeding is instituted in a court having jurisdiction
in the premises seeking a decree or order for relief in respect to the Debtor
in an involuntary case under any applicable bankruptcy, insolvency or other
similar law nor or hereafter in effect, or for the appointment of a receiver,
liquidator, assignee, custodian, trustee, sequestrator (or other similar
official) of the Debtor, or for a substantial part of its property, or for the
winding-up or liquidation of it affairs, and such proceeding remains
undismissed or unstayed and in effect for a period of sixty (60) days or such court
enters a decree or order granting the relief sought in such proceeding;

(f)            The Debtor voluntarily suspends transaction of its
business, dissolves or is liquidated, commences a voluntary case under any
applicable bankruptcy, insolvency or other similar law now or hereafter in
effect, consents to the entry of an order for relief in an involuntary case
under any such law, or consents to the appointment of or taking possession by a
receiver, liquidator, assignee, trustee, custodian, sequestrator (or similar
official) of the Debtor, as the case may be, or for any substantial part of its
property, or makes a general assignment for the benefit of creditors; or

(g)           The failure to provide Secured Party with the
Compliance Certificate required by Section 7(c) below.

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EXHIBITI A

Upon the occurrence of any Event of Default
hereunder, (i) the Lender may declare the principal balance of this Note to be
immediately due and payable by written notice to the Debtor, provided, however, in the
case of an Event of Default described in paragraphs (e) or (f) above, all
amounts payable by the Debtor hereunder, including, without limitation, the
principal balance and all accrued interest on this Note, shall automatically
become immediately due and payable, without notice, action or election by the
Lender, and (ii) the Lender may enforce all other rights and remedies granted
pursuant to this Note, the Letter of Credit, any other document, or by
applicable law.  Without limitation, upon
an Event of Default, Secured Party may draw upon the entire Letter of
Credit.  If the proceeds of the Letter of
Credit are insufficient to fully satisfy Debtor’s obligations under this Note,
Debtor shall be fully liable for any deficiency.  All of the rights of the Lender hereunder
shall be cumulative and not exclusive, and each of which may be exercised
singly, repetitively, in any combination, and in any order.  The Lender’s rights and remedies hereunder
may be exercised without resort or regard to any other source of satisfaction
of any liabilities owing by the Debtor to the Lender.  No inconsistency between the default
provisions of this Note and any other agreement shall be deemed to create any
additional notice, cure or grace period or derogate from the express terms of
such provisions.

Upon the occurrence of an Event of Default, the
Debtor agrees to pay on demand all costs and expenses (including, without
limitation, reasonable attorneys’ fees) incurred or paid by the Lender in
collecting or enforcing this Note.

5.             Waiver

No delay or omission on the part of the Lender in
exercising any right under this Note shall operate as a waiver of such right or
of any other right of the Lender, nor shall any delay, omission or waiver on
any one occasion be deemed a bar to or waiver of the same or any other right on
any future occasion.  No course of
dealing or other conduct, no oral agreement or representation made by the
Lender or usage of trade shall operate as a waiver remedy of the Lender.  The Debtor, by executing this Note, and any
other makers, sureties, guarantors or endorsers, by endorsing this Note or by
entering into or executing any agreement to pay any of the indebtedness
evidenced hereby, waives (to the fullest extent allowed by law) all
requirements of diligence in collection, demand, presentment, notice of
non-payment, protest, notice of protest, suit and all other conditions
precedent in connection with the collection and enforcement of this Note or any
security for this Note or any guarantee of the indebtedness evidenced hereby
(other than demand for payment if expressly required by this Note).  This Note shall be binding upon the
successors and assigns of the Debtor.

6.             General

6.1           Governing Law. 
This Note shall be governed by and construed in accordance with the laws
of the Commonwealth of Massachusetts.

6.2           Assignment. 
Neither the Lender nor the Debtor may assign its rights or obligations
hereunder without the prior written consent of the other party.

6.3           Saturdays, Sundays, Holidays.  If any date that may at any time be specified
in this Note as a date for the making of any payment on this Note shall fall on
Saturday, Sunday or on a day which in the Commonwealth of Massachusetts shall
be a legal holiday, then the date for the making of that payment shall be the
next subsequent day which is not a Saturday, Sunday or legal holiday.

6.4           Notices. 
Except in the case of notices and other communications expressly
permitted to be given by telephone, all notices and other communications
provided for herein shall be in writing and shall be delivered by hand or
overnight courier service, mailed by certified or registered mail or sent by
telecopy, as follows:

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EXHIBIT A

(a)                                   if to the Lender, to Genzyme Corporation, 500
Kendall Street, Cambridge, MA  02142,
Attn: Mr. Michael Wyzga, Telephone: (617) 252-7500, Facsimile: (617) 252-7802;
with a copy to:  Genzyme Corporation, One
Kendall Square, Cambridge, Massachusetts 02139-1562, Attn: Chief Legal Officer,
Telephone: (617) 252-7500, Facsimile: (617) 252-7553; and

(b)                                  if to the Debtor, to Dyax Corp., 300 Technology
Square, Cambridge, Massachusetts 02139, Attention:  Chief Financial Officer, Telephone: (617)
225-2500, Facsimile: (617) 225-2501), with a copy to:  Dyax Corp., 300 Technology Square, Cambridge,
Massachusetts 02139, Attention: Corporate Counsel, Telephone: (617) 225-2500,
Facsimile: (617) 225-2501).

6.5           Entire Agreement. 
This Note, together with the Letter of Credit and the Collaboration
Agreement, contains the entire agreement between the parties with respect to
the subject matter hereof, and supersedes every course of dealing, other
conduct, oral agreement or representation previously made by the Lender.  All prior agreements between the Debtor and
the Lender concerning the lending and borrowing of money are hereby terminated.

6.6           Severability. 
In the event that any court of competent jurisdiction shall determine
that any provision, or portion thereof, contained in this Note shall be
unenforceable in any respect, then such provision shall be deemed limited to
the extent that such court deems it enforceable, and the remaining provisions
of this Note shall nevertheless remain in full force and effect.

6.7           Amendments. 
None of the terms or provisions of this Note may be excluded, modified,
or amended except by a written instrument duly executed on behalf of both the
Debtor and the Lender expressly referring hereto and setting forth the
provision so excluded, modified or amended. 
No waiver or forbearance of any of the rights and remedies of the Lender
hereunder shall be effective unless made specifically in a writing signed by
the Lender, and any such waiver or forbearance shall be effective only in the
specific instance and for the specific purpose for which given.

6.8           Headings. 
The headings in this Note are for convenience only and shall not affect
the interpretation hereof.

6.9           Amends and Restates.  This Note amends, restates and replaces in
its entirety that certain Senior Secured Promissory Note dated May 31, 2002,
made by the Debtor to the order of the Lender in the original, principal amount
of $7,000,000.

7.             Additional
Provisions.

(a)           Representations
and Warranties.  Debtor hereby represents
and warrants that:

(i)                                     no claim, litigation or proceeding is
threatened or pending which would have a material adverse effect on the Debtor;
and

(ii)                                  all indebtedness (as defined by GAAP) of
Debtor existing as of July 31, 2006 is accurately described in Schedule A
attached hereto and the Company has not incurred any material indebtedness
since July 31, 2006.

(b)           Financial
Reports.  Debtor will deliver to the
Secured Party (i) as soon as available, but no later than one hundred twenty
(120) days after the last day of the Debtor’s fiscal year, audited consolidated
financial

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EXHIBIT A

statements
prepared under GAAP, together with an unqualified opinion on the financial
statements from an independent certified public accounting firm reasonably
acceptable to the Secured Party, and (ii) within five (5) days of the filing,
copies of all statements, reports and notices made available to Debtor’s
security holders and all reports on Form 10-K, 10-Q and 8-K filed with the
Securities and Exchange Commission.

(c)           Monthly
Compliance.  No later than five (5)
days after the end of each calendar quarter, Debtor shall provide to Secured
Party a quarterly compliance certificate in the form of Exhibit B
attached hereto (the “Compliance Certificate”).

IN WITNESS WHEREOF, the undersigned has executed this Note under seal as
of August  23, 2006, to be effective as of May 31, 2002.

	
   

  	
  DYAX CORP.

  
	
   

  	
   

  
	
   

  	
   

  
	
   

  	
  By

  	
  /s/ Thomas R.
  Beck

  	
   

  
	
   

  	
  Name: Thomas R. Beck

  
	
   

  	
  Title: President and Chief Operating Officer

  

 

	
  By its signature below, the
  Lender acknowledges the terms of

  	
   

  	
   

  
	
  this Note and
  agrees to be bound by the provisions of this Note

  	
   

  	
   

  
	
  applicable to
  the Lender:

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  GENZYME
  CORPORATION

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  By

  	
  /s/ Michael S.
  Wyzga

  	
   

  	
   

  	
   

  
	
  Name: Michael S. Wyzga

  	
   

  	
   

  
	
  Title: CFO

  	
   

  	
   

  
					

 

 5Exhibit 10.16(c)

EXECUTION COPY

AGREEMENT REGARDING

SENIOR SECURED
PROMISSORY NOTE

                This
AGREEMENT REGARDING SENIOR SECURED PROMISSORY NOTE (“Agreement”), dated
effective as of August  23,
2006 (the “Effective Date”), is entered into by and between Genzyme
Corporation, with its principal office at 500 Kendall Street, Cambridge, MA
02142 (“Genzyme”), and Dyax Corp., with a principal office at 300 Technology Square,
Cambridge, Massachusetts 02139 (“Dyax”).

                WHEREAS,
on May 31, 2002, Genzyme agreed to loan Dyax up the principal amount of Seven
Million Dollars ($7,000,000) or such lesser amount as advanced to Dyax pursuant
to the terms and conditions of a Senior Secured Promissory Note, also dated May
31, 2002 (the “Note”);

                WHEREAS,
as of the date hereof, Dyax has borrowed the entire principal amount of Seven
Million Dollars ($7,000,000);

                WHEREAS,
under the terms of the Note, the principal amount, together with all accrued
and unpaid interest due thereunder, was originally due and payable on the May
31, 2005 (the “Maturity Date”);

                WHEREAS,
under the terms of the Note, Dyax had the right to extend the Maturity Date to
May 31, 2007 if, on the Maturity Date, Dyax met the conditions described in
Schedule A attached to the Note;

                WHEREAS,
the conditions set forth Schedule A being satisfied on the Maturity Date, Dyax
exercised its right to extend the Maturity Date to May 31, 2007; and

                WHEREAS,
Genzyme and Dyax now wish to amend the Note to further extend the Maturity
Date, among other things, and to restate the Note on the terms and conditions
set forth herein.

                NOW,
THEREFORE, in consideration of the promises and agreements set forth herein,
and for other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, Genzyme and Dyax hereby agree as follows:

                1.             Termination of Securitv Agreement; Release of
Collateral. The Security Agreement, dated May 31, 2002, by and between Dyax and Genzyme, as amended to date
(the “Security Agreement”), is hereby terminated in its entirety. As a result
of such termination, Genzyme agrees to take any and all reasonable action
necessary to promptly release all Collateral (as defined therein) currently
pledged to secure the obligations of Dyax under the Security Agreement.

                2.             Amended and Restated Promissory Note. The
Note is hereby amended and restated in its entirety, as set forth on Exhibit
A attached hereto.

                3.             Letter of Credit. In place of the
Collateral, Dyax is concurrently delivering a letter of credit in the form
attached here to as Exhibit B.

                IN
WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed
by their respective duly authorized representatives, under seal, as of the
Effective Date hereof.

	
  GENZYME CORPORATION

  	
   

  	
  DYAX CORP.

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  By: 

  	
  /s/ Michael Wyzga

  	
   

  	
   

  	
  By:

  	
  /s/ Thomas R. Beck

  	
   

  
	
  Name: Michael Wyzga

  	
   

  	
  Name: Thomas R. Beck

  
	
  Title: CFO

  	
   

  	
  Title: President and Chief Operating Officer

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