Document:

EX-10.1

 Exhibit 10.1 
  

			
	 Casdin Capital, LLC

1350 6th Avenue, Suite 2600
 New
York, NY 10019
	  	 Viking Global Investors LP

55 Railroad Avenue
 Greenwich, CT
06830

 March 25, 2022 

Fluidigm Corporation 
 2 Towers Place, Suite 2000 

South San Francisco, CA 94080 
 Attention: Nicholas S. Khadder

 Email: nick.khadder@fluidigm.com 
 Dear Nick: 

Reference is made to (1) the Series B-1 Convertible Preferred Stock Purchase Agreement (the
“Casdin Purchase Agreement”), dated as of January 23, 2022, by and between Fluidigm Corporation (the “Company”), Casdin Private Growth Equity Fund II, L.P. (“Casdin PGEF II”) and Casdin
Partners Master Fund, L.P. (together with Casdin PGEF II, the “Casdin Purchaser”) and (2) the Series B-2 Convertible Preferred Stock Purchase Agreement (the “Viking Purchase
Agreement”), dated as of January 23, 2022, by and between the Company, Viking Global Opportunities Illiquid Investments Sub-Master LP (“VGO Illiquid Investments”) and Viking
Global Opportunities Drawdown (Aggregator) LP (together with VGO Illiquid Investments, the “Viking Purchaser”). Unless the context otherwise requires, capitalized terms used but not otherwise defined in this letter agreement shall
have the respective meanings ascribed to such terms in the Casdin Purchase Agreement. 
 Notwithstanding anything to the contrary set forth
in the Casdin Purchase Agreement or the Viking Purchase Agreement, the parties hereto hereby agree as follows: 
  

	 	1.	 If there are insufficient votes to obtain the Requisite Stockholder Approval as of immediately prior to the
closing of the polls at the Company Stockholder Meeting on March 25, 2022, then the Company shall adjourn the Company Stockholder Meeting until 9 a.m., San Francisco time, on April 1, 2022. 

 

	 	2.	 If the Company fails to obtain the Requisite Stockholder Approval at the Company Stockholder Meeting, as so
adjourned as provided above, then (a) there shall be no further adjournments of the Company Stockholder Meeting and (b) on April 1, 2022, immediately following the closing of the polls at the Company Stockholder Meeting, (i) the
Company and the Casdin Purchaser shall terminate the Casdin Purchase Agreement pursuant to Section 8.1(d) thereof and (ii) the Company and the Viking Purchaser shall terminate the Viking Purchase Agreement pursuant to Section 8.1(d)
thereof. 

 Except as specifically provided herein, this letter agreement shall not constitute an amendment, modification
or waiver of any provision of the Casdin Purchase Agreement (including Section 8.3(b) thereof) or the Viking Purchase Agreement (including Section 8.3(b) thereof), each of which shall continue and remain in full force and effect in
accordance with its terms. Article IX of the Casdin Purchase Agreement is incorporated by reference into this letter agreement, mutatis mutandis. 

[Signature Page Follows] 

 If you are in agreement with the foregoing, please indicate by signing and returning one
copy of this letter agreement, which will constitute our agreement with respect to the matters set forth herein. 
  

			
	Very truly yours,
	
	 CASDIN PRIVATE GROWTH EQUITY FUND II, L.P.
  

By: Casdin Private Growth Equity Fund II GP, LLC, its General Partner

		
	By:	 	 /s/ Kevin O’Brien

		 	Name: Kevin O’Brien
		 	Title:   General Counsel
	
	 CASDIN PARTNERS MASTER FUND, L.P.
  

By: Casdin Partners GP, LLC, its General Partner

		
	By:	 	 /s/ Kevin O’Brien

		 	Name: Kevin O’Brien
		 	Title:   General Counsel
	
	 VIKING GLOBAL OPPORTUNITIES ILLIQUID INVESTMENTS SUB-MASTER LP

 
 By: Viking Global Opportunities Portfolio GP, LLC, its General Partner

		
	By:	 	 /s/ Katerina Novak

		 	Name: Katerina Novak
		 	Title:   Authorized Signatory
	
	 VIKING GLOBAL OPPORTUNITIES DRAWDOWN (AGGREGATOR) LP

 
 By: Viking Global Opportunities Drawdown Portfolio GP LLC, its General
Partner

		
	By:	 	 /s/ Katerina Novak

		 	Name: Katerina Novak
		 	Title:   Authorized Signatory

 Accepted, confirmed and agreed to as of the date first written above: 

FLUIDIGM CORPORATION 
  

			
	By:	 	 /s/ Nicholas S. Khadder

		 	Name: Nicholas S. Khadder
		 	Title: Senior Vice President, General Counsel, and Secretary

 [Signature Page to Side Letter]EX-4.2

 Exhibit 4.2 

DESCRIPTION OF COMMON STOCK 
 The
following description of the common stock of Acumen Pharmaceuticals, Inc., or the Company, and certain provisions of the Company’s amended and restated certificate of incorporation and amended and restated bylaws, and certain provisions of
Delaware law are summaries. These summaries are qualified in their entirety by reference to the provisions of the Delaware General Corporation Law, or the DGCL, and the complete text of the amended and restated certificate of incorporation and
amended and restated bylaws, which are incorporated by reference as Exhibits 3.1 and 3.2, respectively, of the Company’s Annual Report on Form 10-K to which this description is also an exhibit. References
to the terms “we,” “our,” and “us” refer to Acumen Pharmaceuticals, Inc., unless the context requires otherwise. 

General 
 Our amended and restated certificate of
incorporation authorizes us to issue up to 300,000,000 shares of common stock, $0.0001 par value per share, and 10,000,000 shares of preferred stock, $0.0001 par value per share, all of which shares of preferred stock will be undesignated. Our board
of directors may establish the rights and preferences of the preferred stock from time to time. 
 Common Stock 

Voting Rights 
 Each holder of our common stock is
entitled to one vote for each share on all matters submitted to a vote of the stockholders, including the election of directors. The affirmative vote of holders of at least 662/3% of the voting power of all of the then-outstanding shares of capital
stock, voting as a single class, is required to amend certain provisions of our amended and restated certificate of incorporation, including provisions relating to amending our amended and restated bylaws, the classified board, the size of our
board, removal of directors, director liability, vacancies on our board, special meetings, stockholder notices, actions by written consent and exclusive forum. 

Dividends 
 Subject to preferences that may be
applicable to any then-outstanding preferred stock, holders of common stock are entitled to receive ratably those dividends, if any, as may be declared from time to time by the board of directors out of legally available funds. 

Liquidation 
 In the event of our liquidation,
dissolution or winding up, holders of common stock will be entitled to share ratably in the net assets legally available for distribution to stockholders after the payment of all of our debts and other liabilities and the satisfaction of any
liquidation preference granted to the holders of any then-outstanding shares of preferred stock. 
 Rights and Preferences 

Holders of common stock have no preemptive, conversion or subscription rights and there are no redemption or sinking fund provisions applicable to the common
stock. The rights, preferences and privileges of the holders of common stock are subject to, and may be adversely affected by, the right of the holders of shares of any series of preferred stock that we may designate in the future. 

Preferred Stock 
 Our board of directors has the authority
under our amended and restated certificate of incorporation, without further action by our stockholders, to issue up to 10,000,000 shares of preferred stock in one or more series, to establish from time to time the number of shares to be included in
each such series, to fix the rights, preferences and privileges of the shares of each wholly unissued series and any qualifications, limitations or restrictions thereon, and to increase or decrease the number of shares of any such series, but not
below the number of shares of such series then outstanding. 

 Our board of directors may authorize the issuance of preferred stock with voting or conversion rights that
could adversely affect the voting power or other rights of the holders of our common stock. The purpose of authorizing our board of directors to issue preferred stock and determine its rights and preferences is to eliminate delays associated with a
stockholder vote on specific issuances. The issuance of preferred stock, while providing flexibility in connection with possible acquisitions and other corporate purposes, could, among other things, have the effect of delaying, deferring or
preventing a change in control of us and may adversely affect the market price of our common stock and the voting and other rights of the holders of our common stock. It is not possible to state the actual effect of the issuance of any shares of
preferred stock on the rights of holders of common stock until the board of directors determines the specific rights attached to that preferred stock. 
 No
shares of preferred stock are outstanding. 
 Anti-Takeover Provisions 

Section 203 of the Delaware General Corporation Law 

We are subject to Section 203 of the Delaware General Corporation Law, which prohibits a Delaware corporation from engaging in any business combination
with any interested stockholder for a period of three years after the date that such stockholder became an interested stockholder, with the following exceptions: 
  

	•	 	 before such date, the board of directors of the corporation approved either the business combination or the
transaction that resulted in the stockholder becoming an interested stockholder; 

  

	•	 	 upon completion of the transaction that resulted in the stockholder becoming an interested stockholder, the
interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction began, excluding for purposes of determining the voting stock outstanding, but not the outstanding voting stock owned by the
interested stockholder, those shares owned (i) by persons who are directors and also officers and (ii) employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to the
plan will be tendered in a tender or exchange offer; or 

  

	•	 	 on or after such date, the business combination is approved by the board of directors and authorized at an annual
or special meeting of the stockholders, and not by written consent, by the affirmative vote of at least 662/3% of the outstanding voting stock that is not owned by the interested stockholder. 

In general, Section 203 defines a “business combination” to include the following: 

 

	•	 	 any merger or consolidation involving the corporation or any direct or indirect majority-owned subsidiary of the
corporation and the interested stockholder; 

  

	•	 	 any sale, transfer, pledge or other disposition of 10% or more of the assets of the corporation involving the
interested stockholder (in one transaction or a series of transactions); 

  

	•	 	 subject to certain exceptions, any transaction that results in the issuance or transfer by the corporation or by
any direct or indirect majority-owned subsidiary of the corporation of any stock of the corporation or of such subsidiary to the interested stockholder; 

  

	•	 	 any transaction involving the corporation or any direct or indirect majority-owned subsidiary of the corporation
that has the effect of increasing the proportionate share of the stock or any class or series of the corporation beneficially owned by the interested stockholder; or 

 

	•	 	 the receipt by the interested stockholder of the benefit of any loans, advances, guarantees, pledges or other
financial benefits by or through the corporation. 

 In general, Section 203 defines an “interested stockholder” as an
entity or person who, together with the person’s affiliates and associates, beneficially owns, or within three years prior to the time of determination of interested stockholder status did own, 15% or more of the outstanding voting stock of the
corporation. 
 Amended and Restated Certificate of Incorporation and Amended and Restated Bylaws 

Our amended and restated certificate of incorporation provides for our board of directors to be divided into three classes with staggered three-year terms.
Only one class of directors is elected at each annual meeting of our 

 
stockholders, with the other classes continuing for the remainder of their respective three-year terms. Because our stockholders do not have cumulative voting rights, stockholders holding a
majority of the shares of common stock outstanding are able to elect all of our directors. Our amended and restated certificate of incorporation and our amended and restated bylaws provide that directors may be removed by the stockholders only for
cause upon the vote of 66 2⁄3% or more of our outstanding common stock. Furthermore, the authorized number of directors may be changed only by resolution of
the board of directors, and vacancies and newly created directorships on the board of directors may, except as otherwise required by law or determined by the board, only be filled by a majority vote of the directors then serving on the board, even
though less than a quorum. 
 Under our amended and restated certificate of incorporation and our amended and restated bylaws our stockholders do not have
cumulative voting rights. Because of this, the holders of a majority of the shares of common stock entitled to vote in any election of directors can elect all of the directors standing for election, if they should so choose. 

Our amended and restated certificate of incorporation and our amended and restated bylaws also provide that all stockholder actions must be effected at a duly
called meeting of stockholders and eliminate the right of stockholders to act by written consent without a meeting. Our amended and restated bylaws also provide that only our Chairman of the board, Chief Executive Officer or the board of directors
pursuant to a resolution adopted by a majority of the total number of authorized directors may call a special meeting of stockholders. 
 Our amended and
restated bylaws also provide that stockholders seeking to present proposals before a meeting of stockholders to nominate candidates for election as directors at a meeting of stockholders must provide timely advance notice in writing, and specify
requirements as to the form and content of a stockholder’s notice. 
 Our amended and restated certificate of incorporation and our amended and
restated bylaws provide that the stockholders cannot amend many of the provisions described above except by a vote of 66 2⁄3% or more of our outstanding common
stock. As described in “—Preferred Stock” above, our amended and restated certificate of incorporation gives our board of directors the authority, without further action by our stockholders, to issue up to 10,000,000 shares of
preferred stock in one or more series, with any rights, preferences and privileges as they may designate, including the right to approve an acquisition or other change in control. 

The combination of these provisions makes it more difficult for our existing stockholders to replace our board of directors as well as for another party to
obtain control of us by replacing our board of directors. Since our board of directors has the power to retain and discharge our officers, these provisions could also make it more difficult for existing stockholders or another party to effect a
change in management. In addition, the authorization of undesignated preferred stock makes it possible for our board of directors to issue preferred stock with voting or other rights or preferences that could impede the success of any attempt to
change our control. 
 These provisions are intended to enhance the likelihood of continued stability in the composition of our board of directors and its
policies and to discourage coercive takeover practices and inadequate takeover bids. These provisions are also designed to reduce our vulnerability to hostile takeovers and to discourage certain tactics that may be used in proxy fights. However,
such provisions could have the effect of discouraging others from making tender offers for our shares and may have the effect of delaying changes in our control or management. As a consequence, these provisions may also inhibit fluctuations in the
market price of our stock that could result from actual or rumored takeover attempts. We believe that the benefits of these provisions, including increased protection of our potential ability to negotiate with the proponent of an unfriendly or
unsolicited proposal to acquire or restructure our company, outweigh the disadvantages of discouraging takeover proposals, because negotiation of takeover proposals could result in an improvement of their terms. 

Choice of Forum 
 Our amended and restated certificate of
incorporation provides that the Court of Chancery of the State of Delaware (or, if and only if, the Court of Chancery of the State of Delaware lacks subject matter jurisdiction, any state court located within the State of Delaware or, if and only
if, all such state courts lack subject matter jurisdiction, the federal district court for the District of Delaware) and any appellate court therefrom shall be the sole and exclusive forum for the following claims or causes of action brought under
Delaware statutory or common law: (1) any 

 
derivative claim or action brought on our behalf; (2) any claim or cause of action asserting a breach of fiduciary duty by any of our current or former director, officer or other employee;
(3) any claim or cause of action asserting a claim against us arising out of, or pursuant to, the DGCL, our amended and restated certificate of incorporation or our amended and restated bylaws; (4) any claim or cause of action seeking to
interpret, apply, enforce or determine the validity of our amended and restated certificate of incorporation or our amended and restated bylaws (including any right, obligation, or remedy thereunder); (5) any claim or cause of action as to which the
DGCL confers jurisdiction to the Court of Chancery of the State of Delaware; or (6) any claim or cause of action asserting a claim against us or any of our directors, officers or other employees, that is governed by the internal affairs
doctrine, in all cases to the fullest extent permitted by law and subject to the court having personal jurisdiction over the indispensable parties named as defendants. The aforementioned provision does not apply to claims or causes of action brought
to enforce a duty or liability created by the Securities Act, the Exchange Act or any other claim for which the federal courts have exclusive jurisdiction. 

In addition, our amended and restated certificate of incorporation further provides that, unless we consent in writing to the selection of an alternative
forum, the federal district courts of the United States of America is the exclusive forum, to the fullest extent permitted by law, for resolving any complaint asserting a cause or causes of action arising under the Securities Act, including all
causes of action asserted against any defendant to such complaint. For the avoidance of doubt, this provision is intended to benefit and may be enforced by us, our officers and directors, the underwriters to any offering giving rise to such
complaint, and any other professional entity whose profession gives authority to a statement made by that person or entity and who has prepared or certified any part of the documents underlying the offering. 

The enforceability of similar choice of forum provisions in other companies’ certificates of incorporation has been challenged in legal proceedings, and
it is possible that, in connection with one or more actions or proceedings described above, a court could find the choice of forum provisions contained in our amended and restated certificate of incorporation to be inapplicable or unenforceable.

 Transfer Agent and Registrar 
 The transfer agent and
registrar for our common stock is American Stock Transfer & Trust Company, LLC. The transfer agent’s address is 6201 15th Avenue, Brooklyn, NY 11219. 

Listing 
 Our common stock is listed on the Nasdaq Global
Select Market under the trading symbol “ABOS.”

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