Document:

EX-10.1

 Exhibit 10.1 

CIRIUS THERAPEUTICS, INC. 

LOAN AND SECURITY AGREEMENT 

 This LOAN AND SECURITY AGREEMENT (the “Agreement”) is entered into as of March 6, 2018, by and
between PACIFIC WESTERN BANK, a California state chartered bank (“Bank”) and CIRIUS THERAPEUTICS, INC. (“Borrower”). 

RECITALS 
 Borrower wishes to obtain
credit from time to time from Bank, and Bank desires to extend credit to Borrower. This Agreement sets forth the terms on which Bank will advance credit to Borrower, and Borrower will repay the amounts owing to Bank. 

AGREEMENT 
 The parties agree as follows:

 1.    DEFINITIONS AND CONSTRUCTION. 

1.1    Definitions. As used in this Agreement, all capitalized terms shall have the definitions set forth on
Exhibit A. Any term used in the Code and not defined herein shall have the meaning given to the term in the Code. 

1.2    Accounting Terms. Any accounting term not specifically defined on Exhibit A shall be construed in
accordance with GAAP and all calculations shall be made in accordance with GAAP (except for non-compliance with FAS 123R in monthly reporting). The term “financial statements” shall include the
accompanying notes and schedules. 
 2.    LOAN AND TERMS OF PAYMENT. 

2.1    Credit Extensions. 

(a)    Promise to Pay. Borrower promises to pay to Bank, in lawful money of the United States of America,
the aggregate unpaid principal amount of all Credit Extensions made by Bank to Borrower, together with interest on the unpaid principal amount of such Credit Extensions at rates in accordance with the terms hereof. 

(b)    Term Loan. 

(i)    Subject to and upon the terms and conditions of this Agreement, Bank agrees to make one (1) or more
term loans to Borrower in an aggregate principal amount not to exceed the Term Loan Commitment (each a “Term Loan” and collectively the “Term Loans”). Borrower may request Term Loans at any time from the date hereof through the
Availability End Date. The proceeds of the Term Loans shall be used for general working capital purposes. 
 (1)    Up
to Five Million Dollars ($5,000,000) of the Term Loan Commitment (“Tranche A”) shall be available through the Availability End Date, provided Borrower achieves the Tranche A Availability Requirement. Funds will be

  
 1. 

 
available under Tranche A as soon as Borrower delivers to Bank evidence reasonably satisfactory to Bank that Borrower has achieved the Tranche A Availability Requirement. 

(2)    The remaining Five Million Dollars ($5,000,000) of the Term Loan Commitment (“Tranche B”) shall be
available through the Availability End Date, provided Borrower achieves the Tranche B Availability Requirement. Funds will be available under Tranche B as soon as Borrower delivers to Bank evidence reasonably satisfactory to Bank that Borrower has
achieved the Tranche B Availability Requirement. 
 (ii)    Interest shall accrue from the date of each Term Loan
at the rate specified in Section 2.3(a), and, prior to the Availability End Date, shall be payable monthly beginning on the 6th day of the month next following each such Term Loan, and continuing on the same day of each month thereafter. Any
Term Loans that are outstanding on the Availability End Date shall be payable in 30 equal monthly installments of principal, plus all accrued interest (provided however, that if Borrower achieves the Tranche B Availability Requirement, the Term
Loans shall instead be payable in 24 equal monthly installments of principal, plus all accrued interest), beginning on the 6th day of the month immediately after the Availability End Date, and continuing on the same day of each month thereafter
through the Term Loan Maturity Date, at which time all amounts due in connection with the Term Loans and any other amounts due under this Agreement shall be immediately due and payable. Term Loans, once repaid, may not be reborrowed. Borrower may
prepay any Term Loan without penalty or premium. 
 (iii)    When Borrower desires to obtain a Term Loan,
Borrower shall notify Bank (which notice shall be irrevocable) by facsimile transmission to be received no later than 3:30 p.m. Eastern time on the day on which the Term Loan is to be made. Such notice shall be substantially in the form of Exhibit
C. The notice shall be signed by an Authorized Officer or its designee. 
 (c)    Usage of Credit Card
Services Under the Credit Card Line. 
 (i)    Usage Period. Subject to and upon the terms and
conditions of this Agreement, at any time from the Closing Date through the Credit Card Maturity Date, Borrower may use the Credit Card Services (as defined below) in amounts and upon terms as provided in Section 2.1(c)(ii) below. 

(ii)    Credit Card Services. Subject to and upon the terms and conditions of this Agreement, Borrower may
request corporate credit cards and standard and e-commerce merchant account services from Bank (collectively, the “Credit Card Services”). The aggregate limit of the corporate credit cards and
merchant credit card processing reserves shall not exceed the Credit Card Line. The terms and conditions (including repayment and fees) of such Credit Card Services shall be subject to the terms and conditions of Bank’s standard forms of
application and agreement for the Credit Card Services, which Borrower hereby agrees to execute. 

(iii)    Collateralization of Obligations Extending Beyond Maturity. If Borrower has not cash secured its
obligations with respect to any Credit Card Services by the Credit Card Maturity Date, then, effective as of such date, the balance in any 

  
 2. 

 
deposit accounts held by Bank and the certificates of deposit or time deposit accounts issued by Bank in Borrower’s name (and any interest paid thereon or proceeds thereof, including any
amounts payable upon the maturity or liquidation of such certificates or accounts), shall automatically secure such obligations to the extent of the then continuing or outstanding Credit Card Services. Borrower authorizes Bank to hold such balances
in pledge and to decline to honor any drafts thereon or any requests by Borrower or any other Person to pay or otherwise transfer any part of such balances for so long as the applicable Credit Card Services are outstanding or continue. 

2.2    Reserved. 

2.3    Interest Rates, Payments, and Calculations. 

(a)    Interest Rates. 

(i)    Term Loans. Except as set forth in Section 2.3(b), the Term Loans shall bear
interest, on the outstanding daily balance thereof, at a variable annual rate equal to the greater of: (A) 0.50% above the Prime Rate then in effect; or (B) 4.75%. 

(b)    Late Fee; Default Rate. If any payment is not made within 15 days after the date such payment is due,
Borrower shall pay Bank a late fee equal to the lesser of (i) 5% of the amount of such unpaid amount or (ii) the maximum amount permitted to be charged under applicable law. All Obligations shall bear interest, from and after the occurrence and
during the continuance of an Event of Default, at a rate equal to 5 percentage points above the interest rate applicable immediately prior to the occurrence of the Event of Default. 

(c)    Payments. Borrower authorizes Bank to, at its option, charge such interest, all Bank Expenses, and
all Periodic Payments against any of Borrower’s deposit accounts, in which case those amounts shall thereafter accrue interest at the rate then applicable hereunder. Any interest not paid when due shall be compounded by becoming a part of the
Obligations, and such interest shall thereafter accrue interest at the rate then applicable hereunder. All payments shall be free and clear of any taxes, withholdings, duties, impositions or other charges, to the end that Bank will receive the
entire amount of any Obligations payable hereunder, regardless of source of payment. 

(d)    Computation. In the event the Prime Rate is changed from time to time hereafter, the applicable rate
of interest hereunder shall be increased or decreased, effective as of the day the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest chargeable under the Loan Documents shall be computed on the basis of a 360
day year for the actual number of days elapsed. 
 2.4    Crediting Payments. Prior to the occurrence of an
Event of Default, Bank shall credit a wire transfer of funds, check or other item of payment to such deposit account or Obligation as Borrower specifies, except that to the extent Borrower uses the Term Loans to purchase Collateral, Borrower’s
repayment of the Term Loans shall apply on a “first-in-first-out” basis so that the portion of the Term Loans used to
purchase a particular item of Collateral shall be paid in the chronological order the Borrower purchased the Collateral. After the occurrence and during the continuance of an Event of Default, Bank shall have the right, in its sole discretion,

  
 3. 

 
to immediately apply any wire transfer of funds, check, or other item of payment Bank may receive to conditionally reduce Obligations, but such applications of funds shall not be considered a
payment on account unless such payment is of immediately available federal funds or unless and until such check or other item of payment is honored when presented for payment. Notwithstanding anything to the contrary contained herein, any wire
transfer or payment received by Bank after 5:30 p.m. Eastern time shall be deemed to have been received by Bank as of the opening of business on the immediately following Business Day. Whenever any payment to Bank under the Loan Documents would
otherwise be due (except by reason of acceleration) on a date that is not a Business Day, such payment shall instead be due on the next Business Day, and additional fees or interest, as the case may be, shall accrue and be payable for the period of
such extension. 
 2.5    Fees. Borrower shall pay to Bank the following: 

(a)    Facility Fee. On or before the Closing Date, a facility fee equal to $15,000, which shall be
nonrefundable; 
 (b)    Bank Expenses. On the Closing Date, all Bank Expenses incurred through the
Closing Date (provided that, if there are no more than two turns of the Loan Documents, legal fees charged to Borrower in connection with the initial documentation and closing of this Agreement shall not exceed $20,000), and, after the Closing Date,
all Bank Expenses, as and when they become due. 
 2.6    Term. This Agreement shall become effective on
the Closing Date and, subject to Section 12.7, shall continue in full force and effect for so long as any Obligations remain outstanding or Bank has any obligation to make Credit Extensions under this Agreement. Notwithstanding the foregoing,
Bank shall have the right to terminate its obligation to make Credit Extensions under this Agreement immediately and without notice upon the occurrence and during the continuance of an Event of Default. 

3.    CONDITIONS OF LOANS. 

3.1    Conditions Precedent to Closing. The agreement of Bank to enter into this Agreement on the Closing
Date is subject to the condition precedent that Bank shall have received, in form and substance satisfactory to Bank, each of the following items and completed each of the following requirements: 

(a)    this Agreement; 

(b)    an officer’s certificate of Borrower with respect to incumbency and resolutions authorizing the
execution and delivery of this Agreement; 
 (c)    a financing statement (Form
UCC-1); 
 (d)    payment of the fees and Bank Expenses then due
specified in Section 2.5, which may be debited from any of Borrower’s accounts with Bank; 

  
 4. 

 (e)    current SOS Reports indicating that except for Permitted
Liens, there are no other security interests or Liens of record in the Collateral; 
 (f)    current financial
statements, including audited statements (or such other level required by the Investment Agreement) for Borrower’s 2016 fiscal year, together with an unqualified opinion (or an opinion qualified only for going concern so long as Borrower’s
investors provide additional equity as needed), company prepared consolidated balance sheets, income statements, and statements of cash flows for the most recently ended month in accordance with Section 6.2, and such other updated
financial information as Bank may reasonably request; 
 (g)    current Compliance Certificate in accordance with
Section 6.2; 
 (h)    evidence reasonably satisfactory to Bank that the insurance policies required by
Section 6.5 hereof are in full force and effect, together with appropriate evidence showing loss payable and additional insured clauses or endorsements in favor of Bank, 

(i)    a Warrant in form and substance satisfactory to Bank; and 

(j)    such other documents or certificates, and completion of such other matters, as Bank may reasonably request.

 3.2    Conditions Precedent to all Credit Extensions. The obligation of Bank to make each Credit
Extension, including the initial Credit Extension, is contingent upon the Borrower’s compliance with Section 3.1 above, and is further subject to the following conditions: 

(a)    timely receipt by Bank of the Loan Advance/Paydown Request Form as provided in Section 2.1; 

(b)    Borrower shall have transferred substantially all of its Cash assets into operating accounts held with Bank
and otherwise be in compliance with Section 6.6 hereof; 
 (c)    in Bank’s sole discretion, there has
not been a Material Adverse Effect; and 
 (d)    the representations and warranties contained in Section 5
shall be true and correct in all material respects on and as of the date of such Loan Advance/Paydown Request Form and on the effective date of each Credit Extension as though made at and as of each such date, and no Event of Default shall have
occurred and be continuing, or would exist after giving effect to such Credit Extension (provided, however, that those representations and warranties expressly referring to another date shall be true and correct in all material respects as of such
date, and provided further that any representation or warranty that contains a materiality qualification therein shall be true and correct in all respects). The making of each Credit Extension shall be deemed to be a representation and warranty by
Borrower on the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2. 

4.    CREATION OF SECURITY INTEREST. 

  
 5. 

 4.1    Grant of Security Interest. Borrower grants and pledges
to Bank a continuing security interest in the Collateral to secure prompt repayment of any and all Obligations and to secure prompt performance by Borrower of each of its covenants and duties under the Loan Documents. Except for Permitted Liens or
as disclosed in the Schedule, such security interest constitutes a valid, first priority security interest in the presently existing Collateral, and will constitute a valid, first priority security interest in later-acquired Collateral. Except for
Permitted Liens or as disclosed in the Schedule, Borrower also hereby agrees not to sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its intellectual property. Notwithstanding any termination
of this Agreement or of any filings undertaken related to Bank’s rights under the Code, Bank’s Lien on the Collateral shall remain in effect for so long as any Obligations are outstanding. 

4.2    Perfection of Security Interest. Borrower authorizes Bank to file at any time financing statements,
continuation statements, and amendments thereto that (i) either specifically describe the Collateral or describe the Collateral as all assets of Borrower of the kind pledged hereunder, and (ii) contain any other information required by the
Code for the sufficiency of filing office acceptance of any financing statement, continuation statement, or amendment, including whether Borrower is an organization, the type of organization and any organizational identification number issued to
Borrower, if applicable. Borrower shall have possession of the Collateral, except where expressly otherwise provided in this Agreement or where Bank chooses to perfect its security interest by possession in addition to the filing of a financing
statement. Where Collateral is in possession of a third party bailee, Borrower shall take such steps as Bank reasonably requests for Bank to (i) subject to Section 7.11 below, obtain an acknowledgment, in form and substance reasonably
satisfactory to Bank, of the bailee that the bailee holds such Collateral for the benefit of Bank, and (ii) obtain “control” of any Collateral consisting of investment property, deposit accounts, letter-of-credit rights or electronic chattel paper (as such items and the term “control” are defined in Revised Article 9 of the Code) by causing the securities intermediary or depositary
institution or issuing bank to execute a control agreement in form and substance reasonably satisfactory to Bank. Borrower will not create any chattel paper without placing a legend on the chattel paper acceptable to Bank indicating that Bank has a
security interest in the chattel paper. Borrower from time to time may deposit with Bank specific cash collateral to secure specific Obligations; Borrower authorizes Bank to hold such specific balances in pledge and to decline to honor any drafts
thereon or any request by Borrower or any other Person to pay or otherwise transfer any part of such balances for so long as the specific Obligations are outstanding. Borrower shall take such other actions as Bank requests to perfect its security
interests granted under this Agreement. 
 5.    REPRESENTATIONS AND WARRANTIES. 

Borrower represents and warrants as follows: 

5.1    Due Organization and Qualification. Borrower and each Subsidiary is duly existing under the laws of
the state in which it is organized and qualified and licensed to do business in any state in which the conduct of its business or its ownership of property requires that it be so qualified, except where the failure to do so would not reasonably be
expected to cause a Material Adverse Effect. 

  
 6. 

 5.2    Due Authorization; No Conflict. The execution, delivery,
and performance of the Loan Documents are within Borrower’s powers, have been duly authorized, and are not in conflict with nor constitute a breach of any provision contained in Borrower’s Certificate of Incorporation or Bylaws, nor will
they constitute an event of default under any material agreement by which Borrower is bound. Borrower is not in default under any agreement by which it is bound, except to the extent such default would not reasonably be expected to cause a Material
Adverse Effect. 
 5.3    Collateral. Borrower has rights in or the power to transfer the Collateral, and
its title to the Collateral is free and clear of Liens, adverse claims, and restrictions on transfer or pledge except for Permitted Liens. Other than movable items of personal property such as laptop computers, all Collateral having an aggregate
book value in excess of $500,000, is located solely in the Collateral States. All Inventory is in all material respects of good and merchantable quality, free from all material defects, except for Inventory for which adequate reserves have been
made. Except as set forth in the Schedule, none of the Borrower’s Cash is maintained or invested with a Person other than Bank or Bank’s affiliates. 

5.4    Intellectual Property. Borrower is the sole owner of the intellectual property created or purchased by
Borrower, except for (a) licenses granted by Borrower to its customers in the ordinary course of business, (b) licenses permitted under clause (d) of the definition of Permitted Lien, (c) over-the-counter software that is commercially available to the public , and (d) outbound licenses disclosed in the Schedule, which Borrower confirms are
non-material to the ability of Borrower to repay the Obligations or otherwise perform its obligations under the Loan Documents. To the best of Borrower’s knowledge, each of the copyrights, trademarks and
patents created or purchased by Borrower is valid and enforceable, and no part of the intellectual property created or purchased by Borrower has been judged invalid or unenforceable, in whole or in part, and no claim has been made to Borrower that
any part of the intellectual property created or purchased by Borrower violates the rights of any third party except to the extent such invalidity, unenforceability, or claim would not reasonably be expected to cause a Material Adverse Effect. 

5.5    Name; Location of Chief Executive Office. Except as disclosed in the Schedule, Borrower has not done
business under any name other than that specified on the signature page hereof, and its exact legal name is as set forth in the first paragraph of this Agreement. The chief executive office of Borrower is located at the address indicated in
Section 10 hereof. 
 5.6    Litigation. Except as set forth in the Schedule, there are no actions or
proceedings pending by or against Borrower or any Subsidiary before any court or administrative agency in which a likely adverse decision would reasonably be expected to have a Material Adverse Effect. 

5.7    No Material Adverse Change in Financial Statements. All consolidated and consolidating (if applicable)
financial statements related to Borrower and its Subsidiaries that are delivered by Borrower to Bank fairly present in all material respects Borrower’s consolidated and consolidating (if applicable) financial condition as of the date thereof
and Borrower’s consolidated and consolidating (if applicable) results of operations for the period then ended, 

  
 7. 

 
subject to restatement of Borrower’s 2016 financial statements relating to noncash items. There has not been a material adverse change in the consolidated or in the consolidating (if
applicable) financial condition of Borrower since the date of the most recent of such financial statements submitted to Bank. 

5.8    Solvency, Payment of Debts. Borrower is able to pay its debts (including trade debts) as they mature;
the fair saleable value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably small capital after the transactions contemplated by this Agreement.

 5.9    Compliance with Laws and Regulations. Borrower and each Subsidiary have met the minimum funding
requirements of ERISA with respect to any employee benefit plans subject to ERISA. No event has occurred resulting from Borrower’s failure to comply with ERISA that is reasonably likely to result in Borrower’s incurring any liability that
could have a Material Adverse Effect. Borrower is not an “investment company” or a company “controlled” by an “investment company” within the meaning of the Investment Company Act of 1940. Borrower is not engaged
principally, or as one of its important activities, in the business of extending credit for the purpose of purchasing or carrying margin stock (within the meaning of Regulations T and U of the Board of Governors of the Federal Reserve System).
Borrower has not violated any statutes, laws, ordinances or rules applicable to it, the violation of which would reasonably be expected to have a Material Adverse Effect. Borrower and each Subsidiary have filed or caused to be filed all tax returns
or extensions thereof required to be filed, and have paid, or have made adequate provision for the payment of, all taxes reflected therein except those being contested in good faith with adequate reserves under GAAP or where the failure to file such
returns or pay such taxes would not reasonably be expected to have a Material Adverse Effect. 

5.10    Subsidiaries. Borrower does not own any stock, partnership interest or other equity securities of any
Person, except for Permitted Investments. 
 5.11    Government Consents. Borrower and each Subsidiary have
obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all governmental authorities that are necessary for the continued operation of Borrower’s business as currently conducted,
except where the failure to do so would not reasonably be expected to cause a Material Adverse Effect. 

5.12    Inbound Licenses. Except as disclosed on the Schedule and except for changes for which notice has
been given to Bank pursuant to Section 6.8, Borrower is not a party to, nor is bound by, any material license or other similar agreement important for the conduct of Borrower’s business that prohibits or otherwise restricts Borrower from
granting a security interest in Borrower’s interest in such license or agreement or any other property important for the conduct of Borrower’s business, other than this Agreement or the other Loan Documents. 

5.13    Full Disclosure. No representation, warranty or other statement made by Borrower in any certificate
or written statement furnished to Bank taken together with all such certificates and written statements furnished to Bank contains any untrue statement of a material fact or omits to state a material fact necessary in order to make the statements
contained in such certificates or statements not misleading in light of the circumstances in which they were made, it 

  
 8. 

 
being recognized by Bank that the projections and forecasts provided by Borrower in good faith and based upon reasonable assumptions are not to be viewed as facts and that actual results during
the period or periods covered by any such projections and forecasts may differ from the projected or forecasted results. 

6.    AFFIRMATIVE COVENANTS. 

Borrower covenants that, until payment in full of all outstanding Obligations, and for so long as Bank may have any commitment to make a
Credit Extension hereunder, Borrower shall do all of the following: 
 6.1    Good Standing and Government
Compliance. Borrower shall maintain its and each of its Subsidiaries’ corporate existence and good standing in the respective states of formation, shall maintain qualification and good standing in each other jurisdiction in which the
failure to so qualify would reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the organizational identification number issued to Borrower by the authorities of the state in which Borrower is organized, if
applicable. Borrower shall meet, and shall cause each Subsidiary to meet, the minimum funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. Borrower shall comply, and shall cause each Subsidiary to comply, with
all statutes, laws, ordinances and government rules and regulations to which it is subject, and shall maintain, and shall cause each of its Subsidiaries to maintain, in force all licenses, approvals and agreements, the loss of which or failure to
comply with which would reasonably be expected to have a Material Adverse Effect. 
 6.2    Financial
Statements, Reports, Certificates. 
 (a)    Borrower shall deliver to Bank: (i) as soon as available,
but in any event within 30 days after the end of each calendar month, a company prepared consolidated and consolidating (if applicable) balance sheet, income statement, and statement of cash flows covering Borrower’s operations during such
period, in a form reasonably acceptable to Bank and certified by a Responsible Officer; (ii) as soon as available, but in any event within 270 days after the end of Borrower’s fiscal year, audited (or such other level as is required by the
Investment Agreement) consolidated and consolidating financial statements of Borrower prepared in accordance with GAAP, consistently applied, together with an opinion which is either unqualified, or qualified only for going concern due to
Borrower’s projected need for additional funding to continue operations or otherwise consented to in writing by Bank on such financial statements of an independent certified public accounting firm reasonably acceptable to Bank;
(iii) annual budget approved by Borrower’s Board of Directors as soon as available but not later than January 15 of each year during the term hereof; (iv) if applicable, copies of all statements, reports and notices sent or made
available generally by Borrower to its security holders or to any holders of Subordinated Debt and all reports on Forms 10-K and 10-Q filed with the Securities and
Exchange Commission; (v) promptly upon receipt of notice thereof, a report of any legal actions pending or threatened against Borrower or any Subsidiary that could reasonably be expected to result in damages or costs to Borrower or any
Subsidiary of $500,000 or more; (vi) promptly upon receipt, each management letter prepared by Borrower’s independent certified public accounting firm regarding Borrower’s management control systems; and (vii) such budgets, sales
projections, operating plans or other financial information as Bank may reasonably request from time to time. 

  
 9. 

 (b)    Within 30 days after the last day of each month, Borrower
shall deliver to Bank with the monthly financial statements a Compliance Certificate certified as of the last day of the applicable month and signed by a Responsible Officer in substantially the form of Exhibit D hereto. 

(c)    Within 30 days after the last day of each month (and more frequently as and when provided to Borrower’s
board of directors), Borrower shall deliver to Bank clinical trial/enrollment updates. 
 (d)    As soon as
possible and in any event within 3 calendar days after becoming aware of the occurrence or existence of an Event of Default hereunder, a written statement of a Responsible Officer setting forth details of the Event of Default, and the action which
Borrower has taken or proposes to take with respect thereto. 
 (e)     Bank (through any of its officers,
employees, or agents) shall have the right, upon reasonable prior notice, from time to time during Borrower’s usual business hours but no more than twice a year (unless an Event of Default has occurred and is continuing), to inspect
Borrower’s Books and to make copies thereof and to check, test, inspect, audit and appraise the Collateral at Borrower’s expense in order to verify Borrower’s financial condition or the amount, condition of, or any other matter
relating to, the Collateral. 
 Borrower may deliver to Bank on an electronic basis any certificates, reports or information required
pursuant to this Section 6.2, and Bank shall be entitled to rely on the information contained in the electronic files, provided that Bank in good faith believes that the files were delivered by a Responsible Officer. Borrower shall include a
submission date on any certificates and reports to be delivered electronically. 
 6.3    Inventory and
Equipment; Returns. Borrower shall keep all Inventory and Equipment in good and merchantable condition, free from all material defects except for Inventory and Equipment (i) sold in the ordinary course of business, and (ii) for which
adequate reserves have been made, in all cases in the United States and such other locations as to which Borrower gives prior written notice. Returns and allowances, if any, as between Borrower and its account debtors shall be on the same basis and
in accordance with the usual customary practices of Borrower, as they exist on the Closing Date. Borrower shall promptly notify Bank of all returns and recoveries and of all disputes and claims involving inventory having a book value of more than
$500,000. 
 6.4    Taxes. Borrower shall make, and cause each Subsidiary to make, due and timely payment
or deposit of all material federal, state, and local taxes, assessments, or contributions required of it by law, including, but not limited to, those laws concerning income taxes, F.I.C.A., F.U.T.A. and state disability, and will execute and deliver
to Bank, on demand, proof reasonably satisfactory to Bank indicating that Borrower or a Subsidiary has made such payments or deposits and any appropriate certificates attesting to the payment or deposit thereof; provided that Borrower or a
Subsidiary need not make any payment if the amount or validity of such payment is contested in good faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by Borrower or such Subsidiary. 

  
 10. 

 6.5    Insurance. Borrower, at its expense, shall (i) keep
the Collateral insured against loss or damage, and (ii) maintain liability and other insurance, in each case as ordinarily insured against by other owners in businesses similar to Borrower’s. All such policies of insurance shall be in such
form, with such companies, and in such amounts as reasonably satisfactory to Bank. All policies of property insurance shall contain a lender’s loss payable endorsement, in a form reasonably satisfactory to Bank, showing Bank as lender’s
loss payee. All liability insurance policies shall show, or have endorsements showing, Bank as an additional insured. Any such insurance policies shall specify that the insurer must give at least 20 days’ notice (10 days for non-payment of premium) to Bank before canceling its policy for any reason. Within 30 days of the Closing Date, Borrower shall cause to be furnished to Bank a copy of its policies or certificates of insurance
including any endorsements covering Bank or showing Bank as an additional insured. Upon Bank’s request, Borrower shall deliver to Bank certified copies of the policies of insurance and evidence of all premium payments. Proceeds payable under
any casualty policy will, at Borrower’s option, be payable to Borrower to replace the property subject to the claim, provided that any such replacement property shall be deemed Collateral in which Bank has been granted a first priority security
interest (subject only to those Permitted Liens which may pursuant to the terms of this Agreement have priority over Bank’s Liens granted in connection herewith), provided that if an Event of Default has occurred and is continuing, all proceeds
payable under any such policy shall, at Bank’s option, be payable to Bank to be applied on account of the Obligations. 

6.6    Primary Depository. Subject to Section 3.2(b), Borrower within 30 days of the Closing Date shall
maintain all its depository and operating accounts with Bank and all its investment accounts with Bank or Bank’s affiliates; provided that prior to maintaining any investment accounts with Bank’s affiliates, Borrower, Bank, and any such
affiliate shall have entered into a securities account control agreement with respect to any such investment accounts, in form and substance reasonably satisfactory to Bank. Notwithstanding the above, Borrower shall be permitted to maintain an
aggregate amount not to exceed $20,000 in one or more accounts outside of Bank. 
 6.7    Reserved. 

6.8    Protection of Intellectual Property Rights. Borrower shall use commercially reasonable efforts to
(i) protect, defend and maintain the validity and enforceability of the trade secrets, trademarks, patents and copyrights, (ii) use commercially reasonable efforts to detect infringements of the trademarks, patents and copyrights and
promptly advise Bank in writing of material infringements detected and (iii) not allow any material trademarks, patents or copyrights to be abandoned, forfeited or dedicated to the public without the written consent of Bank, which shall not be
unreasonably withheld. 
 6.9    Consent of Inbound Licensors. Prior to entering into or becoming bound by
any material inbound license or agreement, Borrower shall: (i) provide written notice to Bank of the material terms of such license or agreement with a description of its likely impact on Borrower’s business or financial condition; and
(ii) in good faith use commercially reasonable efforts to obtain the consent of, or waiver by, any person whose consent or waiver is necessary for Borrower’s interest in such licenses or contract rights to be deemed Collateral and for Bank
to have a security interest in it that might otherwise be restricted by the terms of the applicable license 

  
 11. 

 
or agreement, whether now existing or entered into in the future, provided, however, that the failure to obtain any such consent or waiver shall not constitute a default under this Agreement.

 6.10    Creation/Acquisition of Subsidiaries. In the event any Borrower or any Subsidiary of any Borrower
creates or acquires any Subsidiary, Borrower or such Subsidiary shall promptly notify Bank of such creation or acquisition, and Borrower or such Subsidiary shall take all actions reasonably requested by Bank to achieve any of the following with
respect to such “New Subsidiary” (defined as a Subsidiary formed after the date hereof during the term of this Agreement): (i) to cause New Subsidiary to become either a
co-Borrower hereunder, if such New Subsidiary is organized under the laws of the United States, or a secured guarantor with respect to the Obligations; and (ii) to grant and pledge to Bank a perfected
security interest in 100% of the stock, units or other evidence of ownership held by Borrower or its Subsidiaries of any such New Subsidiary which is organized under the laws of the United States, and 65% of the stock, units or other evidence of
ownership held by Borrower or its Subsidiaries of any such New Subsidiary which is not organized under the laws of the United States. 

6.11    Further Assurances. At any time and from time to time Borrower shall execute and deliver such further
instruments and take such further action as may reasonably be requested by Bank to effect the purposes of this Agreement. 

7.    NEGATIVE COVENANTS. 

Borrower covenants and agrees that, so long as any credit hereunder shall be available and until the outstanding Obligations are paid in full
or for so long as Bank may have any commitment to make any Credit Extensions, Borrower will not do any of the following without Bank’s prior written consent, which shall not be unreasonably withheld: 

7.1    Dispositions. Convey, sell, lease, license, transfer or otherwise dispose of (collectively, to
“Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, or move cash balances on deposit with Bank to accounts opened at another financial institution, other than Permitted Transfers. 

7.2    Change in Name, Location, Executive Office, or Executive Management; Change in Business; Change in Fiscal
Year; Change in Control. Change its name or the state of Borrower’s formation or relocate its chief executive office without 30 days prior written notification to Bank; replace or suffer the departure of its chief executive officer or chief
financial officer without delivering written notification to Bank within 10 Business Days thereafter; fail to appoint an interim replacement or fill a vacancy in the position of chief executive officer or chief financial officer for more than 60
consecutive days; prior to an IPO, suffer a change on its board of directors which results in the failure of at least one partner of both Frazier Healthcare Partners and Novo A/S or their Affiliates to serve as voting members, in such case without
the prior written consent of Bank which may be withheld in Bank’s sole discretion; take action to liquidate, wind up, or otherwise cease to conduct business in the ordinary course; engage in any business, or permit any of its Subsidiaries to
engage in any business, other than or reasonably related or incidental to the businesses currently engaged in by Borrower; change its fiscal year end; have a Change in Control. 

  
 12. 

 7.3    Mergers or Acquisitions. Merge or consolidate, or permit
any of its Subsidiaries to merge or consolidate, with or into any other business organization (other than mergers or consolidations of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit any of its Subsidiaries to acquire,
all or substantially all of the capital stock or property of another Person except where (a) each of the following conditions is applicable: (i) the consideration paid in connection with such transactions (including assumption of
liabilities) does not in the aggregate exceed $500,000 during any fiscal year, (ii) no Event of Default has occurred, is continuing or would exist after giving effect to such transactions, (iii) such transactions do not result in a Change
in Control, and (iv) Borrower is the surviving entity; or (b) the Obligations are repaid in full concurrently with the closing of any merger or consolidation of Borrower in which Borrower is not the surviving entity; provided, however,
that Borrower shall not, without Bank’s prior written consent, enter into any binding contractual arrangement with any Person to attempt to facilitate a merger or acquisition of Borrower; provided however, Borrower may enter into any such
agreement without Bank’s prior written consent so long as (i) no Event of Default exists when such agreement is entered into by Borrower, (ii) such agreement does not give such Person the right to claim any fee, payment or damages
from any parties, other than from Borrower or Borrower’s investors, in connection with a sale of Borrower’s stock or assets pursuant to or resulting from an assignment for the benefit of creditors, an asset turnover to Borrower’s
creditors (including, without limitation, Bank), foreclosure, bankruptcy or similar liquidation, and (iii) Borrower notifies Bank in advance of entering into such an agreement (provided, the failure to give such notification shall not be deemed
a material breach of this Agreement). 
 7.4    Indebtedness. Create, incur, assume, guarantee or be or
remain liable with respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness, or prepay any Indebtedness or take any actions which impose on Borrower an obligation to prepay any Indebtedness, except
Indebtedness to Bank. 
 7.5    Encumbrances. Create, incur, assume or allow any Lien with respect to its
property, or assign or otherwise convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens, or covenant to any other Person (other than (i) the licensors of in-licensed property with respect to such property or (ii) the lessors of specific equipment or lenders financing specific equipment with respect to such leased or financed equipment) that Borrower in the
future will refrain from creating, incurring, assuming or allowing any Lien with respect to any of Borrower’s property. 

7.6    Distributions. Pay any dividends or make any other distribution or payment on account of or in
redemption, retirement or purchase of any capital stock, except that Borrower may (i) repurchase the stock of former or current employees, directors, officers, or consultants pursuant to stock repurchase agreements in an aggregate amount not to
exceed $500,000 in any fiscal year, as long as an Event of Default does not exist prior to such repurchase or would not exist after giving effect to such repurchase, and (ii) repurchase the stock of former or current employees, officers, or
directors pursuant to stock repurchase agreements by the cancellation of indebtedness owed by such former employees or directors to Borrower regardless of whether an Event of Default exists. 

7.7    Investments. Directly or indirectly acquire or own an Investment in, or make any Investment in or to
any Person, or permit any of its Subsidiaries so to do, other than 

  
 13. 

 
Permitted Investments, or, except as permitted pursuant to Section 6.6 hereof, maintain or invest any of its investment property with a Person other than Bank or permit any Subsidiary to do
so unless such Person has entered into a control agreement with Bank, in form and substance reasonably satisfactory to Bank, or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that restricts such Subsidiary from paying
dividends or otherwise distributing property to Borrower. 
 7.8    Capitalized Expenditures. Make
Capitalized Expenditures in excess of $500,000 in the aggregate in any fiscal year of Borrower. 

7.9    Transactions with Affiliates. Directly or indirectly enter into or permit to exist any material
transaction with any Affiliate of Borrower except for (i) transactions that are in the ordinary course of Borrower’s business, upon fair and reasonable terms that are no less favorable to Borrower than would be obtained in an arm’s
length transaction with a non-affiliated Person, (ii) Investments permitted under subclause (e) of the definition of Permitted Investments, and (iii) the sale of Borrower’s equity
securities in bona fide transactions with Borrower’s existing investors that do not result in a Change in Control. 

7.10    Subordinated Debt. Make any payment in respect of any Subordinated Debt, or permit any of its
Subsidiaries to make any such payment, except in compliance with the terms of such Subordinated Debt, or amend any provision affecting Bank’s rights contained in any documentation relating to the Subordinated Debt without Bank’s prior
written consent. 
 7.11    Inventory and Equipment. Store the Inventory or the Equipment of a book value
in excess of $500,000 with a bailee, warehouseman, collocation facility or similar third party unless the third party has been notified of Bank’s security interest and Bank (a) has received an acknowledgment from the third party that it is
holding or will hold the Inventory or Equipment for Bank’s benefit or (b) is in possession of the warehouse receipt, where negotiable, covering such Inventory or Equipment. Except for Inventory sold in the ordinary course of business and
for movable items of personal property having an aggregate book value not in excess of $500,000, and except for such other locations as Bank may approve in writing, Borrower shall keep the Inventory and Equipment only at the location set forth in
Section 10 and such other locations of which Borrower gives Bank prior written notice and as to which Bank is able to take such actions as may be necessary or advisable to perfect its security interest or to obtain a bailee’s
acknowledgment of Bank’s rights in the Collateral. 
 7.12    No Investment Company; Margin
Regulation. Become or be controlled by an “investment company,” within the meaning of the Investment Company Act of 1940, or become principally engaged in, or undertake as one of its important activities, the business of extending
credit for the purpose of purchasing or carrying margin stock, or use the proceeds of any Credit Extension for such purpose. 

8.    EVENTS OF DEFAULT. 

Any one or more of the following events shall constitute an Event of Default by Borrower under this Agreement: 

  
 14. 

 8.1    Payment Default. If Borrower fails to pay any of the
Obligations when due; 
 8.2    Covenant Default. 

(a)    If Borrower fails to perform any obligation under Sections 6.2 (financial reporting), 6.4 (taxes), 6.5
(insurance), or 6.6 (primary accounts), or violates any of the covenants contained in Article 7 of this Agreement; or 

(b)    If Borrower fails or neglects to perform or observe any other material term, provision, condition, covenant
contained in this Agreement, in any of the Loan Documents, or in any other present or future agreement between Borrower and Bank and as to any default under such other term, provision, condition or covenant that can be cured, has failed to cure such
default within 10 days after Borrower receives notice thereof or any officer of Borrower becomes aware thereof; provided, however, that if the default cannot by its nature be cured within the 10 day period or cannot after diligent attempts by
Borrower be cured within such 10 day period, and such default is likely to be cured within a reasonable time, then Borrower shall have an additional reasonable period (which shall not in any case exceed 30 days) to attempt to cure such default, and
within such reasonable time period the failure to have cured such default shall not be deemed an Event of Default but no Credit Extensions will be made; 

8.3    Material Adverse Change. If there occurs any circumstance or any circumstances which would reasonably
be expected to have a Material Adverse Effect; 
 8.4    Attachment. If any material portion of
Borrower’s assets is attached, seized, subjected to a writ or distress warrant, or is levied upon, or comes into the possession of any trustee, receiver or person acting in a similar capacity and such attachment, seizure, writ or distress
warrant or levy has not been removed, discharged or rescinded within 10 days, or if Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct all or any material part of its business affairs, or if a
judgment or other claim becomes a lien or encumbrance upon any material portion of Borrower’s assets, or if a notice of lien, levy, or assessment is filed of record with respect to any material portion of Borrower’s assets by the United
States Government, or any department, agency, or instrumentality thereof, or by any state, county, municipal, or governmental agency, and the same is not paid within ten days after Borrower receives notice thereof, provided that none of the
foregoing shall constitute an Event of Default where such action or event is stayed or an adequate bond has been posted pending a good faith contest by Borrower (provided that no Credit Extensions will be made during such cure period); 

8.5    Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is commenced by Borrower, or
if an Insolvency Proceeding is commenced against Borrower and is not dismissed or stayed within 45 days (provided that no Credit Extensions will be made prior to the dismissal of such Insolvency Proceeding); 

8.6    Other Agreements. If (a) there is a default or other failure to perform in any agreement to which
Borrower is a party with a third party or parties (i) resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of $500,000, (ii) in connection with any
lease of real property, or (iii) that 

  
 15. 

 
would reasonably be expected to have a Material Adverse Effect, or (b) any default or event of default (however designated) shall occur with respect to any Subordinated Debt which is not
cured within any applicable cure period; 
 8.7    Judgments. If a final, uninsured judgment or judgments
for the payment of money in an amount, individually or in the aggregate, of at least $500,000 shall be rendered against Borrower and shall remain unsatisfied and unstayed for a period of 10 days (provided that no Credit Extensions will be made prior
to the satisfaction or stay of the judgment); or 
 8.8    Misrepresentations. If any material
misrepresentation or material misstatement exists now or hereafter in any warranty or representation set forth herein or in any certificate delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter into this
Agreement or any other Loan Document. 
 9.    BANK’S RIGHTS AND REMEDIES. 

9.1    Rights and Remedies. Upon the occurrence and during the continuance of an Event of Default, Bank may,
at its election, without notice of its election and without demand, do any one or more of the following, all of which are authorized by Borrower: 

(a)    Declare all Obligations, whether evidenced by this Agreement, by any of the other Loan Documents, or
otherwise, immediately due and payable (provided that upon the occurrence of an Event of Default described in Section 8.5 (insolvency), all Obligations shall become immediately due and payable without any action by Bank); 

(b)    Demand that Borrower (i) deposit cash with Bank in an amount equal to the amount of any Letters of
Credit remaining undrawn, as collateral security for the repayment of any future drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees scheduled to be paid or payable over the remaining term of the Letters of
Credit, and Borrower shall promptly deposit and pay such amounts; 
 (c)    Cease advancing money or extending
credit to or for the benefit of Borrower under this Agreement or under any other agreement between Borrower and Bank; 

(d)    Settle or adjust disputes and claims directly with account debtors for amounts, upon terms and in whatever
order that Bank reasonably considers advisable; 
 (e)    Make such payments and do such acts as Bank considers
necessary or reasonable to protect its security interest in the Collateral. Borrower agrees to assemble the Collateral if Bank so requires, and to make the Collateral available to Bank as Bank may designate. Borrower authorizes Bank to enter the
premises where the Collateral is located, to take and maintain possession of the Collateral, or any part of it, and to pay, purchase, contest, or compromise any encumbrance, charge, or lien which in Bank’s determination appears to be prior or
superior to its security interest and to pay all expenses incurred in connection therewith. With respect to any of Borrower’s owned premises, Borrower hereby grants Bank a license to enter into possession of such premises and to occupy the
same, without charge, in order to exercise any of Bank’s rights or remedies provided herein, at law, in equity, or otherwise; 

  
 16. 

 (f)    place a “hold” on any account maintained with Bank
and/or deliver a notice of exclusive control, any entitlement order, or other directions or instructions pursuant to any control agreement or similar agreements providing control of any Collateral; 

(g)    Set off and apply to the Obligations any and all (i) balances and deposits of Borrower held by Bank,
and (ii) indebtedness at any time owing to or for the credit or the account of Borrower held by Bank; 

(h)    Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell (in
the manner provided for herein) the Collateral. Bank is hereby granted a license or other right, solely pursuant to the provisions of this Section 9.1, to use, without charge, Borrower’s labels, patents, copyrights, rights of use of any
name, trade secrets, trade names, trademarks, service marks, and advertising matter, or any property of a similar nature, as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in
connection with Bank’s exercise of its rights under this Section 9.1, Borrower’s rights under all licenses and all franchise agreements shall inure to Bank’s benefit; 

(i)    Sell the Collateral at either a public or private sale, or both, by way of one or more contracts or
transactions, for cash or on terms, in such manner and at such places (including Borrower’s premises) as Bank determines is commercially reasonable, and apply any proceeds to the Obligations in whatever manner or order Bank deems appropriate.
Bank may sell the Collateral without giving any warranties as to the Collateral. Bank may specifically disclaim any warranties of title or the like. This procedure will not be considered adversely to affect the commercial reasonableness of any sale
of the Collateral. If Bank sells any of the Collateral upon credit, Borrower will be credited only with payments actually made by the purchaser, received by Bank, and applied to the indebtedness of the purchaser. If the purchaser fails to pay for
the Collateral, Bank may resell the Collateral and Borrower shall be credited with the proceeds of the sale; 

(j)    Bank may credit bid and purchase at any public sale; 

(k)    Apply for the appointment of a receiver, trustee, liquidator or conservator of the Collateral, without
notice and without regard to the adequacy of the security for the Obligations and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of the Obligations; and 

(l)    Any deficiency that exists after disposition of the Collateral as provided above will be paid immediately by
Borrower. 
 Bank may comply with any applicable state or federal law requirements in connection with a disposition of the Collateral and compliance will
not be considered adversely to affect the commercial reasonableness of any sale of the Collateral. 

9.2    Power of Attorney. Effective only upon the occurrence and during the continuance of an Event of
Default, Borrower hereby irrevocably appoints Bank (and any of Bank’s designated officers, or employees) as Borrower’s true and lawful attorney to: (a) send requests for verification of Accounts or notify account debtors of
Bank’s security interest in the Accounts; (b) endorse Borrower’s name on any checks or other forms of payment or security that 

  
 17. 

 
may come into Bank’s possession; (c) sign Borrower’s name on any invoice or bill of lading relating to any Account, drafts against account debtors, schedules and assignments of
Accounts, verifications of Accounts, and notices to account debtors; (d) dispose of any Collateral; (e) make, settle, and adjust all claims under and decisions with respect to Borrower’s policies of insurance; (f) settle and
adjust disputes and claims respecting the accounts directly with account debtors, for amounts and upon terms which Bank determines to be reasonable; and (g) file, in its sole discretion, one or more financing or continuation statements and
amendments thereto, relative to any of the Collateral; provided Bank may exercise such power of attorney to sign the name of Borrower on any of the documents described in clause (g) above, regardless of whether an Event of Default has occurred.
The appointment of Bank as Borrower’s attorney in fact, and each and every one of Bank’s rights and powers, being coupled with an interest, is irrevocable until all of the Obligations have been fully repaid and performed and Bank’s
obligation to provide advances hereunder is terminated. 
 9.3    Accounts Collection. At any time after
the occurrence and during the continuation of an Event of Default, Bank may notify any Person owing funds to Borrower of Bank’s security interest in such funds and verify the amount of such Account. Borrower shall collect all amounts owing to
Borrower for Bank, receive in trust all payments as Bank’s trustee, and immediately deliver such payments to Bank in their original form as received from the account debtor, with proper endorsements for deposit. 

9.4    Bank Expenses. If Borrower fails to pay any amounts or furnish any required proof of payment due to
third persons or entities, as required under the terms of this Agreement, then Bank may do any or all of the following after reasonable notice to Borrower: (a) make payment of the same or any part thereof; and/or (b) obtain and maintain
insurance policies of the type discussed in Section 6.5 of this Agreement, and take any action with respect to such policies as Bank deems prudent. Any amounts so paid or deposited by Bank shall constitute Bank Expenses, shall be immediately
due and payable, and shall bear interest at the then applicable rate hereinabove provided, and shall be secured by the Collateral. Any payments made by Bank shall not constitute an agreement by Bank to make similar payments in the future or a waiver
by Bank of any Event of Default under this Agreement. 
 9.5    Bank’s Liability for Collateral. Bank
has no obligation to clean up or otherwise prepare the Collateral for sale. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 

9.6    No Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the Obligations by
collecting them from any other person liable for them and Bank may release, modify or waive any collateral provided by any other Person to secure any of the Obligations, all without affecting Bank’s rights against Borrower. Borrower waives any
right it may have to require Bank to pursue any other Person for any of the Obligations. 
 9.7    Remedies
Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements shall be cumulative. Bank shall have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in
equity. No exercise by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event of Default on Borrower’s part shall be deemed a continuing waiver. No delay by Bank

  
 18. 

 
shall constitute a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a written document signed on behalf of Bank and then shall be effective only in the
specific instance and for the specific purpose for which it was given. Borrower expressly agrees that this Section 9.7 may not be waived or modified by Bank by course of performance, conduct, estoppel or otherwise. 

9.8    Demand; Protest. Except as otherwise provided in this Agreement, Borrower waives demand, protest,
notice of protest, notice of default or dishonor, notice of payment and nonpayment and any other notices relating to the Obligations. 

10.    NOTICES. 

Unless otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement or any other agreement entered
into in connection herewith shall be in writing and (except for financial statements and other reporting required pursuant to Section 6.2 of this Agreement, which shall be sent as directed in the monthly reporting forms provided by Bank) shall
be personally delivered or sent by a recognized overnight delivery service, certified mail, postage prepaid, return receipt requested, or by telefacsimile or electronic mail to Borrower or to Bank, as the case may be, at its addresses set forth
below: 
  

			
	If to Borrower:	  	Cirius Therapeutics, Inc.
		  	12651 High Bluff Drive, Suite 150
		  	San Diego, CA 92130
		  	Attn: Chief Executive Officer
		  	E-Mail: bbaltera@ciriustx.com
		
	If to Bank:	  	Pacific Western Bank
		  	406 Blackwell Street, Suite 240
		  	Durham, North Carolina 27701
		  	Attn: Loan Operations Manager
		  	FAX: (919) 314-3080
		  	E-Mail: loannotices@square1bank.com
		
	with a copy to:	  	Pacific Western Bank
		  	12481 High Bluff Drive, Suite 350
		  	San Diego, CA 92130
		  	Attn: Rilus Graham
		  	FAX: (858) 436-3501

 The parties hereto may change the address at which they are to receive notices hereunder, by notice in writing
in the foregoing manner given to the other. 
 11.    CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER. 

This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of North Carolina, without regard to principles of
conflicts of law. Jurisdiction shall lie in the State of North Carolina. All disputes, controversies, claims, actions and similar proceedings arising with respect to Borrower’s account or any related agreement or transaction shall be brought

  
 19. 

 
in the General Court of Justice of North Carolina sitting in Durham County, North Carolina or the United States District Court for the Middle District of North Carolina, except as provided below
with respect to arbitration of such matters. BANK AND BORROWER EACH ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH OF THEM, AFTER CONSULTING OR HAVING HAD THE OPPORTUNITY TO CONSULT, WITH COUNSEL
OF THEIR CHOICE, KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES ANY RIGHT ANY OF THEM MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION BASED UPON OR ARISING OUT OF THIS AGREEMENT OR ANY RELATED INSTRUMENT OR LOAN DOCUMENT OR ANY OF THE TRANSACTIONS
CONTEMPLATED BY THIS AGREEMENT OR ANY COURSE OF CONDUCT, DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN), OR ACTION OF ANY OF THEM. THESE PROVISIONS SHALL NOT BE DEEMED TO HAVE BEEN MODIFIED IN ANY RESPECT OR RELINQUISHED BY BANK OR BORROWER, EXCEPT
BY A WRITTEN INSTRUMENT EXECUTED BY EACH OF THEM. If the jury waiver set forth in this Section 11 is not enforceable, then any dispute, controversy, claim, action or similar proceeding arising out of or relating to this Agreement, the Loan
Documents or any of the transactions contemplated therein shall be settled by final and binding arbitration held in Durham County, North Carolina in accordance with the then current Commercial Arbitration Rules of the American Arbitration
Association by one arbitrator appointed in accordance with those rules. The arbitrator shall apply North Carolina law to the resolution of any dispute, without reference to rules of conflicts of law or rules of statutory arbitration. Judgment upon
any award resulting from arbitration may be entered into and enforced by any state or federal court having jurisdiction thereof. Notwithstanding the foregoing, the parties may apply to any court of competent jurisdiction for preliminary or interim
equitable relief, or to compel arbitration in accordance with this Section. The costs and expenses of the arbitration, including without limitation, the arbitrator’s fees and expert witness fees, and reasonable attorneys’ fees, incurred by
the parties to the arbitration may be awarded to the prevailing party, in the discretion of the arbitrator, or may be apportioned between the parties in any manner deemed appropriate by the arbitrator. Unless and until the arbitrator decides that
one party is to pay for all (or a share) of such costs and expenses, both parties shall share equally in the payment of the arbitrator’s fees as and when billed by the arbitrator. 

12.    GENERAL PROVISIONS. 

12.1    Successors and Assigns. This Agreement shall bind and inure to the benefit of the respective
successors and permitted assigns of each of the parties and shall bind all persons who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor any rights hereunder may be assigned by Borrower without
Bank’s prior written consent, which consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without the consent of or notice to Borrower to sell, assign, transfer, negotiate, or grant participation in all or
any part of, or any interest in, Bank’s obligations, rights and benefits hereunder. 

12.2    Indemnification. Borrower shall defend, indemnify and hold harmless Bank and its officers, employees,
and agents against: (a) all obligations, demands, claims, and liabilities claimed or asserted by any other party in connection with the transactions contemplated by this Agreement; and (b) all losses or Bank Expenses in any way suffered,
incurred, or paid by 

  
 20. 

 
Bank, its officers, employees and agents as a result of or in any way arising out of, following, or consequential to transactions between Bank and Borrower whether under this Agreement, or
otherwise (including without limitation reasonable attorneys’ fees and expenses), except for losses caused by Bank’s gross negligence or willful misconduct. 

12.3    Time of Essence. Time is of the essence for the performance of all obligations set forth in this
Agreement. 
 12.4    Severability of Provisions. Each provision of this Agreement shall be severable from
every other provision of this Agreement for the purpose of determining the legal enforceability of any specific provision. 

12.5    Amendments in Writing, Integration. All amendments to or terminations of this Agreement or the other
Loan Documents must be in writing. All prior agreements, understandings, representations, warranties, and negotiations between the parties hereto with respect to the subject matter of this Agreement and the other Loan Documents, if any, are merged
into this Agreement and the Loan Documents. 
 12.6    Counterparts. This Agreement may be executed in any
number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, shall be deemed to be an original, and all of which, when taken together, shall constitute but one and the same Agreement. Executed
copies of the signature pages of this Agreement sent by facsimile or transmitted electronically in Portable Document Format (“PDF”), or any similar format, shall be treated as originals, fully binding and with full legal force and effect,
and the parties waive any rights they may have to object to such treatment. 
 12.7    Survival. All
covenants, representations and warranties made in this Agreement shall continue in full force and effect so long as any Obligations remain outstanding or Bank has any obligation to make any Credit Extension to Borrower. The obligations of Borrower
to indemnify Bank with respect to the expenses, damages, losses, costs and liabilities described in Section 12.2 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Bank have
run. 
 12.8    Confidentiality. In handling any confidential information, Bank and Borrower and all
employees and agents of such party shall exercise the same degree of care that such party exercises with respect to its own proprietary information of the same types to maintain the confidentiality of any
non-public information thereby received or received pursuant to this Agreement except that disclosure of such information may be made (i) in the case of Bank, to the subsidiaries or Affiliates of Bank or
Borrower in connection with their present or prospective business relations with Borrower, (ii) in the case of Bank, to prospective transferees or purchasers of any interest in the Credit Extensions, provided that they have entered into a
comparable confidentiality agreement in favor of Borrower and have delivered a copy to Borrower, (iii) as required by law, regulations, rule or order, subpoena, judicial order or similar order, (iv) in the case of Bank, as may be required
in connection with the examination, audit or similar investigation of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder. Confidential information hereunder shall not include information that either:
(a) is in the public domain or in the knowledge or possession of the receiving party when disclosed to such 

  
 21. 

 
party, or becomes part of the public domain after disclosure to such receiving party through no fault of such receiving party; or (b) is disclosed to the receiving party by a third party,
provided such receiving party does not have actual knowledge that such third party is prohibited from disclosing such information. 

  
 22. 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first above
written. 
  

			
	CIRIUS THERAPEUTICS, INC.
		
	By:	 	/s/ Robert F. Baltera    
	Name:	 	Robert F. Baltera    
	Title:	 	CEO    
	
	PACIFIC WESTERN BANK
		
	By:	 	/s/ Sean Noonan    
	Name:	 	Sean Noonan    
	Title:	 	Vice President    

  
 23. 

 EXHIBIT A 

DEFINITIONS 
 “Accounts” means all presently existing
and hereafter arising accounts, contract rights, payment intangibles and all other forms of obligations owing to Borrower arising out of the sale or lease of goods (including, without limitation, the licensing of software and other technology) or
the rendering of services by Borrower and any and all credit insurance, guaranties, and other security therefor, as well as all merchandise returned to or reclaimed by Borrower and Borrower’s Books relating to any of the foregoing. 

“Affiliate” means, with respect to any Person, any Person that owns or controls directly or indirectly such Person, any Person that controls or is
controlled by or is under common control with such Person, and each of such Person’s senior executive officers, directors, and general partners. 

“Authorized Officer” means someone designated as such in the corporate resolution provided by Borrower to Bank in which this Agreement and the
transactions contemplated hereunder are authorized by Borrower’s board of directors. If Borrower provides subsequent corporate resolutions to Bank after the Closing Date, the individual(s) designated as “Authorized Officer(s)” in the
most recently provided resolution shall be the only “Authorized Officers” for purposes of this Agreement. 
 “Availability End Date”
means September 30, 2019; provided however, that if Borrower achieves the Tranche B Availability Requirement, the “Availability End Date” shall be extended to March 31, 2020. 

“Bank Expenses” means all reasonable costs or expenses (including reasonable attorneys’ fees and expenses, whether generated by in-house or by outside counsel) incurred in connection with the preparation, negotiation, administration, and enforcement of the Loan Documents; reasonable Collateral audit fees; and Bank’s reasonable
attorneys’ fees and expenses (whether generated in-house or by outside counsel) incurred in amending, enforcing or defending the Loan Documents (including fees and expenses of appeal), incurred before,
during and after an Insolvency Proceeding, whether or not suit is brought. 
 “Borrower’s Books” means all of Borrower’s books and
records including: ledgers; records concerning Borrower’s assets or liabilities, the Collateral, business operations or financial condition; and all computer programs, or tape files, and the equipment, containing such information. 

“Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in the State of North Carolina are authorized or required
to close. 
 “Capitalized Expenditures” means current period unfinanced cash expenditures that are capitalized and amortized over a period of time
in accordance with GAAP, including but not limited to capitalized cash expenditures for capital equipment, capitalized manufacturing and labor costs as they relate to inventory, and capitalized cash expenditures for software development. 

  
 1. 

 “Cash” means unrestricted cash and cash equivalents. 

“Change in Control” shall mean a transaction other than a bona fide equity financing or series of financings on terms and from investors reasonably
acceptable to Bank in which any “person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes the “beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly or indirectly, of a sufficient number of shares of all classes of stock then outstanding of Borrower ordinarily entitled to vote in the election of
directors, empowering such “person” or “group” to elect a majority of the Board of Directors of Borrower, who did not have such power before such transaction; provided, that in no event shall an IPO be deemed to be a Change in
Control. 
 “Closing Date” means the date of this Agreement. 

“Code” means the North Carolina Uniform Commercial Code as amended or supplemented from time to time. 

“Collateral” means the property described on Exhibit B attached hereto and all Negotiable Collateral to the extent not described on Exhibit B,
except to the extent any such property (i) is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the extent such prohibition on transfer is enforceable under applicable law, including, without
limitation, Sections §25-9-406 and §25-9-408 of the Code), (ii) the granting of
a security interest therein is contrary to applicable law, provided that upon the cessation of any such restriction or prohibition, such property shall automatically become part of the Collateral, (iii) constitutes the capital stock of a
controlled foreign corporation (as defined in the IRC), in excess of 65% of the voting power of all classes of capital stock of such controlled foreign corporations entitled to vote, or (iv) property (including any attachments, accessions or
replacements) that is subject to a Lien that is permitted pursuant to clause (c) of the definition of Permitted Liens, if the grant of a security interest with respect to such property pursuant to this Agreement would be prohibited by the
agreement creating such Permitted Lien or would otherwise constitute a default thereunder, provided, that such property will be deemed “Collateral” hereunder upon the termination and release of such Permitted Lien. 

“Collateral State” means the state or states where the Collateral is located, including without limitation California and Michigan. 

“Compliance Certificate” means a compliance certificate, in substantially the form of Exhibit D attached hereto, executed by a Responsible Officer
of the Borrower. 
 “Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or otherwise, of that
Person with respect to (i) any indebtedness, lease, dividend, letter of credit or other obligation of another, including, without limitation, any such obligation directly or indirectly guaranteed, endorsed,
co-made or discounted or sold with recourse by that Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit,
corporate credit cards or merchant services issued for the account of that Person; and (iii) all obligations arising under any interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or
other 

  
 2. 

 
agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; provided, however, that the term “Contingent
Obligation” shall not include endorsements for collection or deposit in the ordinary course of business. The amount of any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount of the primary obligation
in respect of which such Contingent Obligation is made or, if not stated or determinable, the maximum reasonably anticipated liability in respect thereof as determined by such Person in good faith; provided, however, that such amount shall not in
any event exceed the maximum amount of the obligations under the guarantee or other support arrangement. 
 “Credit Card Line” means a Credit
Extension of up to $50,000, to be used exclusively for the provision of Credit Card Services. 
 “Credit Card Maturity Date” means the date that
is 364 days after the Closing Date. 
 “Credit Card Services” has the meaning assigned in Section 2.1(c)(ii) hereof. 

“Credit Extension” means each Term Loan, the Credit Card Services provided under the Credit Card Line, or any other extension of credit by Bank to
or for the benefit of Borrower hereunder. 
 “Equipment” means all present and future machinery, equipment, tenant improvements, furniture,
fixtures, vehicles, tools, parts and attachments in which Borrower has any interest. 
 “ERISA” means the Employee Retirement Income Security Act
of 1974, as amended, and the regulations thereunder. 
 “Event of Default” has the meaning assigned in Article 8. 

“GAAP” means generally accepted accounting principles, consistently applied, as in effect from time to time in the United States. 

“Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of property or services, including without
limitation reimbursement and other obligations with respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or similar instruments, (c) all capital lease obligations, and (d) all
Contingent Obligations, including but not limited to any sublimit contained herein. 
 “Insolvency Proceeding” means any proceeding commenced by
or against any Person or entity under any provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy or insolvency law, including assignments for the benefit of creditors, formal or informal moratoria, compositions,
extension generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 
 “Inventory” means all present and
future inventory in which Borrower has any interest. 
 “Investment” means any beneficial ownership of (including stock, partnership or limited
liability company interest or other securities) any Person, or any loan, advance or capital contribution to any Person. 

  
 3. 

 “Investment Agreement” means, collectively, Borrower’s stock purchase and other agreement(s)
pursuant to which Borrower most recently issued its preferred stock. 
 “IPO” means the sale of Borrower’s equity securities in a public
offering. 
 “IRC” means the Internal Revenue Code of 1986, as amended, and the regulations thereunder. 

“Letter of Credit” means a commercial or standby letter of credit or similar undertaking issued by Bank at Borrower’s request. 

“Lien” means any mortgage, lien, deed of trust, charge, pledge, security interest or other encumbrance. 

“Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower, and any other document, instrument or agreement
entered into in connection with this Agreement, all as amended or extended from time to time. 
 “Material Adverse Effect” means a material
adverse effect on (i) the operations, business or financial condition of Borrower and its Subsidiaries taken as a whole, (ii) the ability of Borrower to repay the Obligations or otherwise perform its obligations under the Loan Documents,
or (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s security interest in the Collateral. The failure to meet Tranche B Availability Requirement shall not automatically by itself be deemed a Material Adverse
Effect, but may, in combination with other factors and conditions, constitute a Material Adverse Effect. 
 “Negotiable Collateral” means all of
Borrower’s present and future letters of credit of which it is a beneficiary, drafts, instruments (including promissory notes), securities, documents of title, and chattel paper, and Borrower’s Books relating to any of the foregoing. 

“New Equity” means Cash proceeds received by Borrower after January 1, 2018 from the sale or issuance of Borrower’s equity securities to
investors acceptable to Bank. 
 “Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to Bank by Borrower
pursuant to this Agreement or any other agreement (other than the Warrant), whether absolute or contingent, due or to become due, now existing or hereafter arising, including any interest that accrues after the commencement of an Insolvency
Proceeding and including any debt, liability, or obligation owing from Borrower to others that Bank may have obtained by assignment or otherwise. 

“Periodic Payments” means all installments or similar recurring payments that Borrower may now or hereafter become obligated to pay to Bank pursuant
to the terms and provisions of any instrument, or agreement now or hereafter in existence between Borrower and Bank. 
 “Permitted Indebtedness”
means: 
 (a)    Indebtedness of Borrower in favor of Bank arising under this Agreement or any other Loan Document; 

  
 4. 

 (b)    Indebtedness existing on the Closing Date and disclosed in the Schedule; 

(c)    Indebtedness not to exceed $500,000 in the aggregate at any time secured by a lien described in clause (c) of the
defined term “Permitted Liens,” provided such Indebtedness does not exceed at the time it is incurred the lesser of the cost or fair market value of the property financed with such Indebtedness; 

(d)    Subordinated Debt; 

(e)    Indebtedness to trade creditors incurred in the ordinary course of business; and 

(f)    Extensions, refinancings and renewals of any items of Permitted Indebtedness, provided that the principal amount is not
increased or the terms modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be. 
 “Permitted Investment”
means: 
 (a)    Investments existing on the Closing Date disclosed in the Schedule; 

(b)    (i) Marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or any
State thereof maturing within one year from the date of acquisition thereof, (ii) commercial paper maturing no more than one year from the date of creation thereof and currently having rating of at least
A-2 or P-2 from either Standard & Poor’s Corporation or Moody’s Investors Service, (iii) Bank’s certificates of deposit maturing no more
than one year from the date of investment therein, and (iv) Bank’s money market accounts; (v) Investments in regular deposit or checking accounts held with Bank or as otherwise permitted by, and subject to the terms and conditions of,
Section 6.6 of this Agreement; and (vi) Investments consistent with any investment policy adopted by the Borrower’s board of directors; 

(c)    Investments accepted in connection with Permitted Transfers; 

(d)    Investments of Subsidiaries in or to other Subsidiaries or Borrower and Investments by Borrower in Subsidiaries not to exceed
$500,000 in the aggregate in any fiscal year; 
 (e)    Investments not to exceed $500,000 outstanding in the aggregate at any
time consisting of (i) travel advances and employee relocation loans and other employee loans and advances in the ordinary course of business, and (ii) loans to employees, officers or directors relating to the purchase of equity securities
of Borrower or its Subsidiaries pursuant to employee stock purchase plan agreements approved by Borrower’s Board of Directors; 

(f)    Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or
suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s business; 

(g)    Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers
who are not Affiliates, in the ordinary course of business, provided that this subparagraph (g) shall not apply to Investments of Borrower in any Subsidiary; 

  
 5. 

 (h)    Joint ventures or strategic alliances in the ordinary course of Borrower’s
business consisting of the non-exclusive licensing of technology, the development of technology or the providing of technical support, provided that any cash Investments by Borrower do not exceed $500,000 in
the aggregate in any fiscal year; and 
 (i)    Investments permitted under Section 7.3 and 7.6. 

“Permitted Liens” means the following: 

(a)    Any Liens existing on the Closing Date and disclosed in the Schedule (excluding Liens to be satisfied with the proceeds of
the Credit Extensions) or arising under this Agreement, the other Loan Documents, or any other agreement in favor of Bank; 

(b)    Liens for taxes, fees, assessments or other governmental charges or levies, either not delinquent or being contested in good
faith by appropriate proceedings and for which Borrower maintains adequate reserves; 
 (c)    Liens not to exceed $500,000 in the
aggregate at any time (i) upon or in any Equipment (other than Equipment financed by a Credit Extension) acquired or held by Borrower or any of its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely for
the purpose of financing the acquisition or lease of such Equipment, or (ii) existing on such Equipment at the time of its acquisition, in each case provided that the Lien is confined solely to the property so acquired and improvements thereon,
and the proceeds of such Equipment; 
 (d)    Liens arising from leases, subleases,
non-exclusive licenses, or non-exclusive sublicenses granted to others in the ordinary course, of Borrower’s business consistent with past practices that do not
interfere in any material respect with the business of Borrower and its Subsidiaries taken as a whole; 
 (e)    Deposits
(i) under worker’s compensation, unemployment insurance social security or other similar laws, (ii) to secure the performance of bids, tenders or contracts (other than for the repayment of borrowed money), (iii) to secure indemnity,
performance or other similar bonds for the performance of bids, tenders or contracts (other than for the repayment of borrowed money), or (iv) to secure statutory obligations (other than liens arising under ERISA or environmental liens), and in
all situations under clauses (i), (ii), (iii), and (iv) the permission granted for such deposits is limited to said deposits being made as the need arises in the ordinary course of Borrower’s business; 

(f)    Liens of materialmen, mechanics, warehousemen, carriers, artisans or other similar liens arising in the ordinary course of
Borrower’s business or by operation of law, which are not past due or which are being contested in good faith by appropriate proceedings and for which reserves have been established to the extent required in accordance with GAAP; 

(g)    Liens incurred in connection with the extension, renewal or refinancing of the indebtedness secured by Liens of the type
described in clauses (a) through (e) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness being extended, renewed or
refinanced does not increase; 

  
 6. 

 (h)    Liens arising from judgments, decrees or attachments in circumstances not
constituting an Event of Default under Sections 8.4 (attachment) or8.8 (judgments); and 
 (i)    Liens in favor of landlords to
secure leases not to exceed $50,000. 
 “Permitted Transfer” means the conveyance, sale, lease, transfer or disposition by Borrower or any
Subsidiary of: 
 (a)    Inventory in the ordinary course of business; 

(b)    licenses and similar arrangements for the use of the property of Borrower or its Subsidiaries in the ordinary course of
business; 
 (c)    worn-out, surplus or obsolete Equipment not financed with the proceeds
of Credit Extensions; 
 (d)    grants of security interests and other Liens that constitute Permitted Liens; and 

(e)    other assets of Borrower or its Subsidiaries that do not in the aggregate exceed $500,000 during any fiscal year. 

“Person” means any individual, sole proprietorship, partnership, limited liability company, joint venture, trust, unincorporated organization,
association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or governmental agency. 
 “Prime
Rate” means the variable rate of interest, per annum, most recently announced by Bank, as its “prime rate,” whether or not such announced rate is the lowest rate available from Bank. 

“Responsible Officer” means each of the Chief Executive Officer, the Chief Operating Officer, the Chief Financial Officer, Vice President of Finance
and the Controller of Borrower, as well as any other officer or employee identified as an Authorized Officer in the corporate resolution delivered by Borrower to Bank in connection with this Agreement. 

“Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any. 

“SOS Reports” means the official reports from the Secretaries of State of each Collateral State, the state where Borrower’s chief executive
office is located, the state of Borrower’s formation and other applicable federal, state or local government offices identifying all current security interests filed in the Collateral and Liens of record as of the date of such report. 

“Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the debt owing by Borrower to Bank on terms reasonably
acceptable to Bank (and identified as being such by Borrower and Bank). 
 “Subsidiary” means any corporation, partnership or limited liability
company or joint venture in which (i) any general partnership interest or (ii) more than 50% of the stock, limited liability company interest or joint venture of which by the terms thereof ordinary voting power to elect the

  
 7. 

 
Board of Directors, managers or trustees of the entity, at the time as of which any determination is being made, is owned by Borrower, either directly or through an Affiliate. 

“Term Loan Commitment” means Ten Million Dollars ($10,000,000). 

“Term Loan Maturity Date” means March 31, 2022. 

“Tranche” means any of Tranche A or Tranche B. 

“Tranche A” has the meaning assigned in Section 2.1(b)(i)(1). 

“Tranche A Availability Requirement” means delivery by Borrower to Bank of both (i) written confirmation reasonably satisfactory to Bank from
Borrower’s board of directors that Borrower has completed enrollment in the EMMINENCE Phase 2b clinical trial; and (ii) evidence reasonably satisfactory to Bank that Borrower has received at least Four Million Dollars ($4,000,000) in New
Equity. 
 “Tranche A Term Loan” or “Tranche A Term Loans” means any Term Loan(s) made under Tranche A. 

“Tranche B” has the meaning assigned in Section 2.1(b)(i)(2). 

“Tranche B Availability Requirement” means delivery by Borrower to Bank of written confirmation satisfactory to Bank in its good faith
discretion from Borrower’s board of directors that the board, in good faith, believes that the findings from interim data generated in the Company’s EMMINENCE Phase 2b trial, are positive and, subject to satisfactory final results, provide
commercially reasonable support for further clinical development of MSDC-0602K. 
 “Tranche B Term Loan” or “Tranche B Term Loans” means
any Term Loan(s) made under Tranche B. 

  
 8. 

DEBTOR                         
   CIRIUS THERAPEUTICS, INC. 
 SECURED PARTY:         PACIFIC WESTERN BANK 

EXHIBIT B 
 COLLATERAL
DESCRIPTION ATTACHMENT TO LOAN AND SECURITY AGREEMENT 
 All personal property of Borrower (herein referred to as “Borrower” or
“Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not limited to: 

(a)    all accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper),
deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), financial assets, general intangibles (including patents, trademarks, copyrights, goodwill, payment intangibles, domain names
and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions), investment property
(including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and records; 

(b)    any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation, insurance proceeds,
and all supporting obligations and the security therefor or for any right to payment. All terms above have the meanings given to them in the North Carolina Uniform Commercial Code, as amended or supplemented from time to time, including revised
Division 9 of the Uniform Commercial Code-Secured Transactions. 
 Notwithstanding the foregoing, the Collateral shall not include any of the
intellectual property, in any medium, of any kind or nature whatsoever, now or hereafter owned or acquired or received by Borrower, or in which Borrower now holds or hereafter acquires or receives any right or interest (collectively, the
“Intellectual Property”); provided, however, that the Collateral shall include all accounts and general intangibles that consist of rights to payment and proceeds from the sale, licensing or disposition of all or any part, or rights in,
the foregoing (the “Rights to Payment”). 
 Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy
Court) holds that a security interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of March 6, 2018 include the Intellectual
Property to the extent and only to the extent necessary to permit perfection of Bank’s security interest in the Rights to Payment, and further provided, however, that Bank’s enforcement rights with respect to any security interest in the
Intellectual Property shall be absolutely limited to the Rights to Payment only, and Bank shall have no recourse whatsoever with respect to the underlying Intellectual Property. 

  
 1. 

 EXHIBIT C 

LOAN ADVANCE/PAYDOWN REQUEST FORM 

[Please refer to New Borrower Kit] 

EXHIBIT D 
 COMPLIANCE
CERTIFICATE 
 [Please refer to New Borrower Kit] 

  
 2.EX-10.2

 Exhibit 10.2 

ASSIGNMENT AND ASSUMPTION OF LEASE 

This Assignment and Assumption of Lease (“Assignment”) is entered into and made effective as of the 1st day of April, 2017,
by and between METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC a Delaware limited liability company (“Assignor”) and CIRIUS THERAPEUTICS,
INC., a Delaware corporation (“Assignee”), and consented to by MAIN STREET EAST, LLC, a Michigan limited liability company (“Landlord”). 

1.    Assignor does hereby grant, convey, transfer and assign to Assignee, its successors and assigns, all of
Assignor’s rights, title and interest in and to that certain Lease Agreement between Landlord and Assignor dated as of November 30, 2009, as amended by that Addendum to Lease Agreement dated as of October 31, 2011, that Second
Addendum to Lease Agreement dated as of December 16, 2014, that Third Addendum to Lease Agreement dated December 16, 2015, and that Fourth Addendum to Lease Agreement dated April 29, 2016 including any security deposit and all other
amendments, modifications, extensions and renewals thereof, a true, full and complete copy of which is attached hereto as Exhibit A (“Lease”), pertaining to the leasing of that certain real property (including all
improvements located thereon) located at 161 East Michigan Avenue, Kalamazoo, Michigan and containing approximately 2,901 square feet of leasable space (“Premises”). 

2.    Assignor represents and warrants, to the best of its knowledge and as of the date hereof, that neither Assignor nor
the Landlord under the Lease, are in breach of or default under any terms and provisions of the Lease and that Assignor is currently paying $3,810 a month under the Lease. 

3.    Assignor hereby agrees to indemnify, protect, defend and hold Assignee harmless from and against all occurrences,
claims, demands, losses, damages, expenses and costs (including reasonable attorneys’ fees) incurred, arising out of, or in connection with Assignor’s failure, prior to the effective date of this Assignment, to observe, perform and
discharge any and all of Assignor’s covenants, obligations and duties pursuant to the Lease. 
 4.    Assignee does
hereby accept and assume such grant, conveyance, transfer and assignment of the Lease, and agrees to perform and be bound by all of the covenants, obligations and duties first arising pursuant to the Lease from and after the effective date of this
Assignment. 
 5.        Assignee hereby agrees to indemnify, protect, defend and hold Assignor
harmless from and against all occurrences, claims, demands, losses, damages, expenses and costs (including reasonable attorneys’ fees) incurred, arising out of, or in connection with Assignee’s failure, after the effective date of this
Assignment, to observe, perform and discharge any and all of the covenants, obligations and duties first arising after the effective date of this Assignment pursuant to the Lease. 

6.    This Assignment may not be assigned by operation of law or otherwise by any party without the prior written consent
of the other parties. This Assignment shall be binding upon and inure to the benefit of the parties and their respective successors and permitted assigns 

 7.    This Assignment shall be governed by, enforced under and construed in
accordance with the laws of the State of Michigan, regardless of the laws that might otherwise govern under applicable principles of conflicts of laws. 

8.    This Assignment may be executed by facsimile, scanned and emailed or other electronic signatures and in
counterparts, each of which shall be deemed to be an original, but all of which shall constitute one and the same agreement. 

9.    Terms not defined herein shall have the meanings ascribed in the Lease. 

[Signature Page Follows] 

									
	ASSIGNOR:	 		 	ASSIGNEE:
			
	 METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC,

a Delaware limited liability Company
	 		 	 CIRIUS THERAPEUTICS, INC.,

a Delaware corporation

					
	By:	 	/s/ Michelle Antunes	 		 	By:	 	/s/ Brian Farmer 
	Name:	 	Michelle Antunes	 		 	Name:	 	Brian K. Farmer
	Title:	 	Manager Finance Administration	 		 	Title:	 	Chief Business Officer

 CONSENT TO AND APPROVAL OF LEASE ASSIGNMENT BY LANDLORD 

The undersigned, duly authorized agent of Landlord, hereby consents to and approves of the assignment of the Lease made herein from Assignor
to Assignee. 
  

			
	 MAIN STREET EAST, LLC,

a Michigan limited liability company

		
	By:	 	/s/ Frederick D. Brown 
	Name:	 	Frederick D. Brown
	Title:	 	Member

 EXHIBIT A 

THE LEASE 

 LEASE AGREEMENT 

THIS LEASE AGREEMENT is made and executed this
    30th     day of November, 2009, by and between MAIN STREET EAST, LLC, hereinafter referred to as “LANDLORD” and
METABOLIC SOLUTIONS DEVELOPMENT COMPANY, a Michigan corporation, hereinafter referred to as “TENANT”. 
 FOR AND IN CONSIDERATION
of the mutual covenants and promises contained herein, the parties hereby agree as follows: 
 1.    Leased
Premises. LANDLORD hereby leases to TENANT and TENANT hereby rents from LANDLORD, the premises located in the City of Kalamazoo Michigan, being the north portion of the 4th floor of The
Haymarket Building (the “Building”) located at 161 E. Michigan Avenue, (“Leased Premises”). The Leased Premises consists of approximately 4,028 square feet, and are shown in yellow highlight on the floor plan attached as
Exhibit A. The Leased Premises shall also include TENANT’S exclusive rights to utilize portions of the Common Areas (defined below) as fully set forth in Section 7. 

2.    Term. The term of this Lease shall commence December 1, 2009 and end on December 31, 2011. 

3.    Rent. The TENANT agrees to pay to the LANDLORD the rental set forth in Exhibit B attached hereto during the
term of this Lease Agreement. The rental shall be paid in equal monthly installments on or before the 1st day of each month, in advance, at the location designated by LANDLORD. 

 

	 	Landlord Designation:	 MAIN STREET EAST, LLC 

c/o Treystar 
 7950 Moorsbridge
Road 
 Portage, MI 49024 

4.    Late Fee. A late fee equal to two (2%) percent of the base monthly rent shall become due and payable
immediately on any rental payment not received on or before the sixth day of the month due. These fees are to be considered as liquidated amounts representing Landlord’s damages and costs of administration on account of late payment.
Tenant’s failure to pay the aforementioned fees as they become due shall constitute a default. 

5.    Restriction on Use. TENANT shall use the Leased Premises only for the conduct of a business or professional
enterprise and other related activities, and for no other purpose without the written consent of LANDLORD. TENANT shall not use the Leased Premises for any unlawful, improper or immoral use, nor for any purpose or in any manner which is in violation
of any present or future governmental laws or regulations. TENANT shall also not undertake any activity within the Leased Premises which might annoy or disturb other tenants in the Building. 

6.    Utilities and Services. TENANT shall be responsible for payment of all gas, electricity, water and sewer used
or consumed in the Leased Premises. Since the Leased Premises is not separately metered for gas, electric, water and sewer, Landlord shall pay all gas, 
  

 
electric, water and sewer bills received for such services furnished to the Building, and promptly notify TENANT of its prorata share of such bills. Tenant’s
pro-rata share will be determined monthly by multiplying the total amount of such bill by a fraction, the numerator of which shall be the square footage of the Leased Premises (4,028 square feet), and the
denominator of which shall be the total leasable square footage in the Building space (presently 39,153 square feet). TENANT shall reimburse Landlord within fifteen days of receiving the notice of its prorata share. Landlord shall have no liability
or responsibility for any failure or interruption of any utilities or services to TENANT unless caused by Landlord’s failure or refusal to pay any utility bill, but, in the event of any such failure or interruption, Landlord and Tenant will
cooperate to remedy such condition as expeditiously as possible. 
 7.    Common Areas and Facilities. TENANT
shall be entitled to use the common areas of the Building, including entryways, hallways, stairwells and elevators (the “Common Areas”). TENANT shall have the right to install, at its cost, a video camera monitoring, recording and
surveillance system covering the fourth floor elevator doors and the fourth floor stairwell doors. TENANT shall also have the exclusive right to control the use of the receptionist station identified in purple highlight on the floor plan attached as
Exhibit A. TENANT shall utilize the freight elevator for the purpose for which it was intended. TENANT shall be responsible for relocking any exterior doors after use by TENANT or its employees or invitees, when the entire Building is not open for
business. TENANT shall also be responsible for locking and securing the Leased Premises. LANDLORD shall pay for lighting in Common Areas and also shall provide a common receptacle for refuse. LANDLORD may furnish certain security facilities for the
Building. If LANDLORD furnishes such facilities, it is with the express understanding that such facilities are furnished gratuitously by LANDLORD and that LANDLORD shall not be liable for any loss of TENANT’S property through theft,
casualty or otherwise, or for any damage or injury whatsoever to TENANT or its employees or invitees, as a result of any non-function or malfunction of such security system. 

8.    Maintenance and Repair. LANDLORD shall keep the foundation, outer walls, roof and structural components of
the Building, including its doors, door frames, door checks, and windows, in good repair as a Class A building. LANDLORD shall also be responsible for all maintenance and repair to the Common Areas, including parking lot and landscaping,
structural components and mechanical systems of the Building, including heating, plumbing and air conditioning equipment; provided, however the LANDLORD shall not be responsible for the expense of repair of damages caused by the acts or negligence
of TENANT or its employees or invitees. LANDLORD shall keep the Common Areas in a clean, sanitary and attractive condition. TENANT shall notify LANDLORD of any repairs which are the responsibility of the LANDLORD to perform. Except as expressly
required elsewhere in this Lease, LANDLORD shall not be called upon to make any other improvements or repairs of any kind upon the Leased Premises and the Leased Premises and appurtenances shall at all times be kept in good order, condition, and
repair by TENANT, and shall also be kept in a clean, sanitary, and safe condition in accordance with the laws of the State of Michigan, and in accordance with all directions, rules and regulations of the health officer, fire marshal, building
inspector or other proper officers of the governmental agencies having jurisdiction, at the sole cost and expense of TENANT, and TENANT shall comply with all said requirements of the law, ordinances and otherwise affecting the Leased Premises.
TENANT shall permit no waste, damage or injury to the Leased Premises, and TENANT shall at its own cost and expense replace any glass windows, doors, door hardware 

  
 2 

 
and frames in the Leased Premises which may be broken by TENANT or its employees or invitees. At the expiration of the tenancy created hereunder, TENANT shall surrender the Leased Premises in as
good condition as when taken, reasonable wear and tear, loss by fire or other unavoidable casualty excepted. Notwithstanding anything in this paragraph contained, there shall be no obligation on the part of TENANT to comply with any of the laws,
directions, rules and regulations referred to which may require structural alterations, structural repairs or structural additions, unless made necessary by act or work performed by TENANT, in which event TENANT shall comply at its expense. 

9.      Alterations. 

(a)    No alterations, additions or improvements shall be made in or to the Leased Premises without the prior consent, in
writing, of LANDLORD, which consent shall not unreasonably be withheld, conditioned or delayed. All alterations, additions, improvements and fixtures which may be made or installed by either of the parties hereto upon the Leased Premises and which
in any manner are attached to the floors, walls or ceilings, with the exception of TENANT’S displays and trade fixtures, shall be the property of LANDLORD and at the termination of this Lease shall remain upon and be surrendered with the Leased
Premises as a part thereof, without disturbance, molestation or injury. Prior to the installation of any alterations, additions or improvements by TENANT, TENANT may obtain LANDLORD’S written approval for TENANT’S removal of certain
improvements at the end of the Lease term. LANDLORD may also designate by written notice to TENANT, which designation must be made at the time LANDLORD’S approval for such alteration, addition or improvement is given, certain fixtures, trade
fixtures, alterations or improvements which shall be removed by TENANT at the expiration of the term. TENANT shall promptly remove any such improvements at the time of expiration of the term and repair any damage to the Leased Premises caused by
such removal. 
 (b)    Notwithstanding the provisions of subsection a. above, LANDLORD consents to TENANT making the
improvements described on attached Exhibit C. 
 10.    Taxes. LANDLORD shall pay all real estate taxes and
installments of special assessments levied against the Leased Premises coming due during the term of this Lease Agreement. TENANT shall pay all personal property taxes levied against the property of the TENANT contained in the Leased Premises coming
due from and after the date of commencement of this Lease. 
 11.    Insurance; Waiver of Claims; Indemnity. 

(a)    Throughout the term of this Lease, LANDLORD shall maintain in force fire and extended coverage insurance insuring
the Building, but not TENANT’S leasehold improvements or personal property, in the name of the LANDLORD and in an amount not less than 80% of replacement value, determined by reappraisal from time to time as deemed necessary by LANDLORD in its
sole discretion. TENANT shall be solely responsible, at his cost, for providing such insurance protecting TENANT’S personal property and leasehold improvements as he deems necessary or desirable. 

  
 3 

 (b)    Throughout the term of this Lease, TENANT shall maintain in force
public liability insurance covering the Leased Premises against liability for personal injuries or property damage arising out of the use, occupation or condition of the Leased Premises, in the following amounts: For personal injuries to any person
or persons arising out of a single accident, $1,000,000, and for property damage resulting from any one occurrence, $100,000. LANDLORD shall be named as an additional insured in all policies of liability insurance maintained pursuant to this section
TENANT shall furnish to LANDLORD a certificate of the insurer evidencing the existence of each such insurance policy obtained pursuant to this section and stating that such insurance shall not be canceled without thirty (30) days’ prior
written notice to LANDLORD. 
 (c)    LANDLORD and TENANT each hereby waive any and every claim for recovery from the
other for any and all loss or damage to the Leased Premises, or any portion thereof, or to the contents thereof, which loss or damage is covered by valid and collectible fire and extended coverage insurance policies, to the extent that such loss or
damage is recoverable under said insurance policies. Inasmuch as this mutual waiver will preclude the assignment of any aforesaid claim by the way of subrogation (or otherwise) to an insurance company (or any other person), LANDLORD and TENANT each
agree to give to each insurance company which has issued its policies of fire and extended coverage insurance, written notice of the terms of this mutual waiver, and to have said insurance policies properly endorsed, if necessary, to prevent the
invalidation of said insurance by reason of said waiver. 
 (d)    TENANT waives all claims against LANDLORD and its
agents and employees for injury to persons or damage to property, including trade fixtures, sustained by TENANT or any person claiming through TENANT, resulting from any occurrence in or upon the Building, except when the same is due to
LANDLORD’S negligent or willful acts. Such claims waived by TENANT include, without limitation, such claims for damages resulting from: (a) any equipment or appurtenances becoming out of repair; (b) injury or damage done or occasioned
by wind, water, flooding, freezing, fire, explosion, earthquake, excessive heat or cold, vandalism, riot or disorder or other casualty; (c) any defect in or failure of plumbing, heating or air conditioning equipment, electric wiring or
installation thereof, water, steam, gas or sewer pipes, stairs, railings or walks; (d) broken glass; (e) the backing up of any sewer pipe or downspout; (f) the bursting, leaking, overflowing, stoppage, or running out of any tank, tub,
washstand, water closet, water pipe, drain, cooling coil or any other pipe or tank in, upon or about the Leased Premises; (g) the escape of steam or hot water; (h) water, snow or ice being upon or coming through the roof, skylight,
trapdoor, stairs, walks or any other place upon or near the Leased Premises or otherwise; (i) the falling of any fixture, plaster, stucco or other object; (j) any act, omission, or negligence of
co-tenants or of other persons or occupants of the Building or owners of adjacent or contiguous property; and (k) damage to or loss by theft or otherwise of property of TENANTS or others, unless such
injuries to persons or damage to property are the result of the willful or negligent acts of LANDLORD. 
 (e)    TENANT
agrees to indemnify, defend and hold harmless LANDLORD and its agents and employees from and against all claims, liabilities, losses, suits, fines, proceedings, and expenses (except those arising out of the negligent or willful acts of LANDLORD and
not covered by TENANT’S insurance), including reasonable attorneys’ fees, for injury to or death of any person or loss of or damage to property in or upon the Leased Premises, and including the

  
 4 

 
person and property of TENANT, its employees, agents, invitees, licensees or others. It is understood and agreed that all of TENANT’S property kept, stored, and maintained in or upon the
Leased Premises or Common Areas, shall be at the risk of TENANT. LANDLORD agrees to indemnify, defend and hold harmless TENANT and its agents and employees from and against all claims, liabilities, losses, suits, fines, proceedings, and expenses
(except those arising out of the negligent or willful acts of TENANT and not covered by LANDLORD’S insurance), including reasonable attorneys’ fees, for injury to or death of any person or loss of or damage to property in or upon the
Building (but not the Leased Premises) and the Common Areas, and including the person and property of LANDLORD, its employees, agents, invitees, licensees or others. 

12.    Access to Leased Premises. LANDLORD shall have the right to enter upon the Leased Premises at all reasonable
hours after reasonable notice for the purpose of inspecting the same, or of making repairs, additions or alterations to the Leased Premises or any property owned or controlled by LANDLORD. LANDLORD shall have reasonable access to the Leased Premises
for the purpose of exhibiting the same to prospective tenants. 
 13.    Condemnation. In the event a part of the
Leased Premises shall be taken under the power of eminent domain by any legally constituted authority, and there remains sufficient amount of space to permit TENANT to carry on its business in a manner comparable to which it has been accustomed,
then this Lease shall continue, but the obligation to pay rent on the part of the TENANT shall be reduced in an amount proportionate to the area and relative value of the portion of the Leased Premises taken by such condemnation. In the event all of
the Leased Premises shall be taken, or so much of the Leased Premises taken that it is not feasible to continue a reasonably satisfactory operation of the business of the TENANT, then this Lease shall be terminated. Such termination shall be without
prejudice to the rights of either the LANDLORD or the TENANT to recover compensation from the condemning authority for any loss or damage caused by such condemnation. Neither LANDLORD nor TENANT shall have any right in or to any award made to the
other by the condemning authority. 
 14.    Destruction. Except as otherwise provided in this Lease, in the
event the Leased Premises, or any portion of the Building, are damaged by fire or other casualty, such damage shall be repaired with reasonable dispatch by and at the expense of LANDLORD. Until such repairs are completed, the rent payable hereunder
shall be abated in proportion to the area of the Leased Premises which is rendered unusable by TENANT in the conduct of its business. 
 In
the event that such repairs cannot, in the reasonable opinion of the parties, be substantially completed within one hundred twenty (120) days after the occurrence of such damage, or if more than fifty (50%) percent of the Leased Premises have
been rendered unoccupiable as a result of such damage, or if there has been a declaration of any governmental authority that the Leased Premises are unsafe or unfit for occupancy, then either LANDLORD or TENANT shall have the right to terminate this
Lease. 
 15.    Bankruptcy or Insolvency. In the event the estate created hereby shall be taken in execution or
by other process of law, or if TENANT shall be adjudicated insolvent or bankrupt pursuant to the provisions of any state or federal insolvency or bankruptcy act, or if a receiver or trustee of the property of TENANT shall be appointed with respect
to TENANT’S property for 

  
 5 

 
the benefits of TENANT’S creditors, then and in any such event, LANDLORD may, at its option, terminate this Lease and all rights of TENANT hereunder, by giving to TENANT notice in writing of
the election of LANDLORD to so terminate. 
 16.    Default of Tenant. In the event of any failure of TENANT to
pay any rental installment due hereunder within ten (10) days after the same shall be due, or any failure to perform any other of the terms, conditions or covenants of this Lease for more than twenty (20) days after written notice of such
default shall have been received by TENANT, or if TENANT shall commit or permit any default in the terms herein, or if TENANT shall abandon the Leased Premises or suffer this Lease to be taken under any writ of execution, then LANDLORD, besides
other rights or remedies it may have, shall have the immediate right of reentry and TENANT’S right of possession of the Leased Premises shall be terminated. LANDLORD shall be entitled to such further rights and remedies as shall be permitted by
law. 
 17.    Quiet Enjoyment. Upon payment by the TENANT of the rents herein provided, and, upon the observance
and performance of all the covenants, terms and conditions on TENANT’S part to be observed and performed, TENANT shall peaceably and quietly hold and enjoy the Leased Premises for the term hereof without hindrance or interruption by LANDLORD or
any other person or persons lawfully or equitably claiming by, through or under the LANDLORD, subject, nevertheless, to the terms and conditions of this Lease. 

18.    Waiver. One or more waivers of any covenant or condition by LANDLORD shall not be construed as a waiver of a
subsequent breach of the same covenant or condition, and the consent or approval by LANDLORD to or of any act of TENANT requiring LANDLORD’S consent or approval shall not be deemed to waive or render unnecessary LANDLORD’S consent or
approval to or of any subsequent similar act by TENANT. 
 19.    Notices. Whenever under this Lease a provision
is made for notice of any kind, it shall be deemed sufficient notice and service thereof if such notice to TENANT is in writing, addressed to TENANT at the last known post office address of TENANT or at the Leased Premises, and sent by registered or
certified mail with postage prepaid, and if such notice to LANDLORD is in writing, addressed to the last known post office address of LANDLORD and sent by registered or certified mail with postage prepaid. Notice need be sent to but one TENANT or
LANDLORD where TENANT or LANDLORD is more than one person. 
 20.    No Partnership. Nothing contained herein
shall be deemed or construed by the parties hereto, nor by any third party, as creating the relationship of principal and agent or partnership or of joint venture between the parties hereto, it being understood and agreed that neither the method of
computation of rent, nor any other provision contained herein, nor any acts of the parties herein, shall be deemed to create any relationship between the parties hereto other than the relationship of LANDLORD and TENANT. Whenever herein the singular
number is used, the same shall include the plural, and the masculine gender shall include the feminine and neuter genders. 

21.    Partial Invalidity. If any term, covenant or condition of this Lease or the application thereof to any
person or circumstance shall, to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such term, covenant or 

  
 6 

 
condition to persons or circumstances other than those as to which it is held invalid or unenforceable, shall not be affected thereby and each term, covenant and condition of this Lease shall be
valid and be enforced to the fullest extent permitted by law. 
 22.    Successors. All rights and liabilities
herein given to, or imposed upon, the respective parties hereto shall extend to and bind the several respective heir~ executors, administrators, successors and assigns of said parties; and if there shall be more than one TENANT, they shall all be
bound jointly and severally by the terms, covenants and agreements herein. No rights, however, shall inure to the benefit of any assignee of TENANT unless the assignment to such assignee has been approved by LANDLORD in writing as provided above.

 23.    Subletting. Tenant agrees not to sell, assign, mortgage, pledge, franchise, or in any manner transfer
this Lease or any estate or interest thereunder and not to Sublet the Leased Premises hereunder or any part thereof without the prior written consent of the Landlord, not to be unreasonably withheld, conditioned or delayed. 

24.    Signs. LANDLORD shall furnish and maintain one sign for TENANT comparable to existing signs upon the
Building directory. Any additional directory listing, if approved by LANDLORD, shall be installed by LANDLORD at the sole cost and expense of TENANT. TENANT shall have the right to install one hallway sign at the entrance to the Leased Premises,
subject to the approval of the size, shape, and design of such sign by Landlord. TENANT shall not erect or install any other exterior signs or any exterior decorations or painting on any portion of the interior or exterior of the Leased Premises
without the prior written consent of LANDLORD. 
 25.    Subordination. LANDLORD reserves the right to subject
and subordinate this Lease at any and all times to the lien of any mortgage or mortgages now or hereafter placed on the Leased Premises and TENANT agrees to further execute and deliver, upon demand, such further instrument subordinating this Lease
to the lien of any such mortgage as shall be desired by LANDLORD, provided, however, that the mortgagee shall first execute and deliver to TENANT an agreement in recordable form under which the mortgagee agrees that in the event of a foreclosure it
will not join the TENANT as a party defendant in the foreclosure action and will not seek to terminate TENANT as a party defendant in the foreclosure action and will not seek to terminate the TENANT’S interest so long as TENANT is not in
default in the performance of its lease obligations, and further that the mortgage will not disturb the possession and other rights of the TENANT under this Lease. 

26.    Improvements. TENANT takes the Leased Premises “as is.” LANDLORD will, at its expense, install
(a) a glass demising wall separating the Leased Premises from the south portion of the 4th floor not within the Leased Premises (the “South Portion”, which is shown by green
highlight on the Floor Plan attached as Exhibit A), and (b) a door with security lock, at such time as (but prior to the commencement date of such lease) LANDLORD executes a lease for the South Portion. The approximate locations of such glass
demising wall and door/security lock are shown on the floor plan attached as Exhibit A. Notwithstanding any other provision in this Lease, until such time as LANDLORD leases the South Portion to another tenant, TENANT may utilize all or any portion
of the South Portion without charge and without an obligation to pay Rent, utilities or other additional charges. 

  
 7 

 27.    Parking. LANDLORD will provide TENANT with one parking space on
the island adjacent to the rear of the Haymarket Building. TENANT will have the right to lease from Treystar up to five (5) parking spaces in Lot 305 (at the corner of Edward Street and Michigan Avenue) at the cost of Sixty ($60.00) Dollars per
space, per month. 
 28.    Commissions. TENANT has no responsibility for any commissions in connection with this
Lease. 
 29.    Security Deposit. Upon execution of this Lease, TENANT shall pay to LANDLORD the sum of Three
Thousand Eight Hundred and 00/100 ($3,800.00) Dollars as a security deposit. LANDLORD may commingle this security deposit with any other funds of the LANDLORD. Upon the termination of this Lease, LANDLORD may, in addition to other remedies, apply
this security deposit in whole or in part to any rent owed by the TENANT or any damages to the Leased Premises caused by Tenant, its invitees and employees. The security deposit is not an advance payment of rent or a measure of LANDLORD’S
damages in event of any loss or default. Upon termination of this Lease, LANDLORD will refund to TENANT any balance of the security deposit remaining after deducting any rent or damages owed by TENANT. 

30.    Right of First Refusal on Balance of Fourth Floor. LANDLORD hereby grants the TENANT a right of first
refusal to lease the South Portion. Notice of a proposed lease, and a copy thereof, which has been accepted by LANDLORD and the proposed tenant, will be given to the TENANT by the LANDLORD in writing. TENANT may elect to lease all, but not less than
all, of the space which is the subject of the proposed lease, on the same terms set forth in the proposed lease, by giving notice thereof to LANDLORD within five (5) days after receipt of the notice and the proposed lease. This right of first
refusal shall expire at the end of the Lease Agreement. 
 31.    Environmental Representations. LANDLORD
warrants and represents that the Building and the Leased Premises are in compliance with all Environmental Laws. Environmental Laws means and includes all now and hereafter existing statutes, laws, ordinances, codes, regulations, rules, rulings,
orders, decrees, directives, policies and requirements by any federal, state or local governmental authority regulating, relating to, or imposing liability or standards of conduct concerning public health and safety or the environment. 

  
 8 

 IN WITNESS WHEREOF, the LANDLORD and TENANT have executed this Agreement on the day and year
first above written. 
  

							
	LANDLORD:	 		 	MAIN STREET EAST, L.L.C.
				
		 		 	By:	 	/s/ illegible
				
		 		 	Its:	 	Member
			
	TENANT:	 		 	METABOLIC SOLUTIONS DEVELOPMENT COMPANY
				
		 		 	By:	 	/s/ Jerry R. Colca
				
		 		 	Its:	 	President

  

  
 9 

 EXHIBIT A 

FLOOR PLAN 
  

  
 10 

 

 

  
 11 

 EXHIBIT B 

RENT SCHEDULE 
 To
the Lease Agreement between Main Street East, L.L.C., a Michigan Limited Liability Company and METABOLIC SOLUTIONS DEVELOPMENT COMPANY., dated November ______, 2009. 

The Leased Premises are more particularly described as the northern portion of the 4th
Floor, consisting of approximately 4,028 square feet of space, “as is”. 
 The base rental due hereunder is as follows: 

 

	 	•	 	 December 2009 through December 2010 – Three thousand Eight Hundred and 00/100 ($3,800.00) Dollars per month.

  

	 	•	 	 January 2011 through December 2011 – Four Thousand and 00/100 ($4,000.00) Dollars per month.

  
 12 

 EXHIBIT C 

APPROVED TENANT ADDITIONS AND IMPROVEMENTS 

1.    Tenant may install a separate high security lock on the server room (such room being shown on the floor plan
attached as Exhibit A to the Lease) or an equivalent room. 
 2.    Tenant may install a halon (or equivalent) fire
suppression system covering the server room or an equivalent room. 
 3.    Tenant may hang the tank for the fire
suppression system on one wall of the mechanical room which is adjacent to the server room. 
 4.    Tenant may during
the Term convert the storage room along the east side of the Leased Premises to additional office space. 
 5.    Tenant
may re-activate, install, upgrade, subdivide, modify and/or replace the security alarm system covering the Leased Premises. Such rights shall include the South Portion, until it is leased by Landlord to
another tenant. 
  

  
 13 

 ADDENDUM TO LEASE AGREEMENT 

THIS ADDENDUM TO LEASE AGREEMENT, made effective the 31st day of October, 2011, by and
between MAIN STREET EAST, LLC, A Michigan Limited Liability Company, herein referred to as “LANDLORD” and METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC, herein referred to as “TENANT” in the manner following: 

RECITALS 
 WHEREAS,
the parties are LANDLORD and TENANT on a Lease dated as of November 30, 2009 (“Lease”) for Suite 4th Floor North of the Haymarket Building – 161 East Michigan Avenue in
Kalamazoo, MI. 
 NOW THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, it is
expressly agreed by and between the parties hereto as follows: 
  

	 	1.	 The Lease Agreement shall be extended an additional three (3) years – commencing January 1, 2012
and expiring December 31, 2014. 

  

	 	2.	 The square footage of the Leased Premises shall increase from 4,028 to 4,076. The space is comprised of 2,969
square feet of space used solely by Tenant, plus 1,107 square feet of Tenant’s share of common area space on the 4th floor. (see attached plan) 

 

	 	3.	 Tenant agrees to pay the following new rental amounts: 

 

	 	-	 January 1, 2012 – December 31,
2012                    $4,755.33 per month 

  

	 	-	 January 1, 2013 – December 31,
2013                    $4,755.33 per month 

  

	 	-	 January 1, 2014 – December 31,
2014                    $4,755.33 per month 

  

	 	4.	 Landlord agrees to provide Tenant with one (1), three (3) year Option term. Tenant agrees to pay the
following rental amounts during the Option term: 

  

	 	-	 January 1, 2015 – December 31,
2015                    $5,196.28 per month 

  

	 	-	 January 1, 2016 – December 31,
2016                    $5,352.17 per month 

  

	 	-	 January 1, 2017 – December 31,
2017                    $5,512.73 per month 

  

	 	5.	 Landlord agrees to pay A.L. Summerfield the sum of One Thousand Seven Hundred eleven and 92/100 dollars
($1,711.92) for brokerage fees associated with the representation of Tenant. 

  

	 	6.	 Right of First Refusal – Tenant shall have a Right of First Refusal on the adjacent Suite – 4th floor South, comprised of 2,306 square feet. The current Lease on 4th floor south expires in August 2012. 

 

	 	7.	 Except as expressly amended above, the terms, covenants and conditions of the lease datedNovember 30, 2009
between LANDLORD and TENANT are hereby ratified and reaffirmed. 

 IN WITNESS WHEREOF, the parties hereto have executed
this Addendum as of the day and year first above written. 

 

 “LANDLORD” 

MAIN STREET EAST LLC 
 By: /s/
Illegible 
 Its: Member

 “TENANT” 

METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC 
 By:
/s/ Stephen Benoit 
 Its: Chief Executive Officer

 

 SECOND ADDENDUM TO LEASE AGREEMENT 

THIS SECOND ADDENDUM TO LEASE AGREEMENT, is made effective this 16th day of December,
2014, by and between MAIN STREET EAST, LLC, A Michigan limited liability company, (“Landlord”), and METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC, a Delaware limited liability company (“Tenant”), in the manner
following: 
 RECITALS 

WHEREAS, the parties are Landlord and Tenant pursuant to a Lease Agreement dated November 30, 2009, as amended by an Addendum to Lease
Agreement dated October 31, 2011 (as amended, the “Lease”), whereby Tenant leased from Landlord approximately 4,076 square feet of office space located in the north portion of the fourth floor of the Haymarket Building – 161 East
Michigan Avenue in Kalamazoo, MI (the “Leased Premises”). 
 NOW THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, it is expressly agreed by and between the parties hereto as follows: 
  

	 	1.	 The Lease shall be extended for one (1) year, commencing January 1, 2015 and expiring
December 31, 2015 (the “Extension Term”). 

  

	 	2.	 Tenant agrees to pay a rental amount of $5,196.28 per month during the Extension Term. 

 

					
	Dates	 	Rate/Square Foot	 	Monthly Payment
			
	 Extension Term
	 		 	
			
	 January 1, 2015-December 31, 2015
	 	$15.30	 	$5,196.28 per month

  

	 	3.	 On or before September 30, 2015, Tenant may exercise any one of the following options, subject to the
terms and conditions set forth herein: 

  

	 	•	 	 Option A – Exercise Renewal on Current Space. Tenant may exercise an option to
renew the Lease for a two (2) year term on the current Leased Premises at the rental rates set forth in the “Option Term” chart below (the “Option Term Rates”). In order to exercise such option, Tenant must provide written
notice of its intent to do so to Landlord at any time on or before September 30, 2015. 

  

	 	•	 	 Option B – Exercise Renewal on Downsized Space. Tenant may exercise an option to
renew the Lease for a two (2) year term on downsized space. Such option would reduce the square footage of the Leased Premises from approximately 4,076 square feet to approximately 3,088 square feet via elimination of approximately 988 square
feet known as the “cube farm”. In order to exercise such option, Tenant must provide written notice of its intent to do so to Landlord at any time on or before September 30, 2015. If Tenant delivers timely notice to downsize, then,
effective January 1, 2016, the square footage of the Leased Premises shall be reduced to approximately 3,088 square feet, and the rental amount for the Leased Premises shall be reduced accordingly, based on the Option Term Rates.

	 	•	 	 Option C – Exercise Renewal on Expanded Space Tenant may exercise an option to
renew the Lease for a two (2) year term on expanded space. Such option would increase the square footage of the Leased Premises from approximately 4,076 square feet to approximately 6,382 square feet by adding the square footage of the suite
known as “4th Floor South” to the square footage of the Leased Premises. In order to exercise such option, Tenant must provide written notice of its intent to do so to Landlord at any
time on or before September 30, 2015. If Tenant delivers timely notice to expand, then, effective January 1, 2016, the Leased Premises shall be expanded to approximately 6,382 square feet, and the rental amount shall be increased
accordingly, based on the Option Term Rates. 

  

			
	Dates	 	Rate/Square Foot
		
	 Option Term
	 	
		
	 January 1, 2016-December 31, 2016
	 	$15.76
		
	 January 1, 2017-December 31, 2017
	 	$16.23

  

	 	4.	 Landlord hereby grants Tenant a right of first refusal to lease the suite known as “4th Floor South”. If Landlord is in negotiations with a proposed tenant for such suite, and such negotiations result in a letter of intent, Landlord shall provide Tenant with a copy of such letter
of intent, together with a copy of the proposed lease. Tenant may elect to lease all, but not less than all, of the space which is the subject of the letter of intent and proposed lease, on the same terms and conditions set forth therein, by giving
Landlord written notice thereof within five (5) days after receipt of such documents. 

  

	 	5.	 Section 19 of the Lease (regarding notices) is hereby deleted in its entirety and is replaced with the
following: 

 “19. Notices. All notices, requests, demands, and other communications required or permitted to
be given hereunder shall be in writing and shall be deemed to have been given if delivered (a) personally, (b) by private national overnight mail delivery service, or (c) by electronic mail, followed by certified mail, return receipt
requested, postage prepaid, to the following addresses, or to such other address as a party may designate by a notice of change in address: 
  

	 	LANDLORD:	 Main Street East, LLC 

	 	    	 c/o Treystar 

	 	    	 Attention: Fritz Brown 

	 	    	 7950 Moorsbridge Road 

	 	    	 Portage, Michigan 49024 

	 	    	 Email: fbrown@treystar.com 

 

	 	TENANT:	 Metabolic Solutions Development Company, LLC 

	 	    	 Attention: Michelle Antunes 

	 	    	 161 East Michigan Avenue, 4th Floor North

	 	    	 Kalamazoo, Michigan 49007 

	 	    	 Email: mantunes@msdrx.com 

  
 2 

	 	6.	 Any inconsistencies between the Lease and this Addendum shall be resolved in favor of this Addendum. Except as
expressly amended herein, the terms, covenants and conditions of the Lease are hereby ratified, affirmed and in full force and effect. 

IN WITNESS WHEREOF, the parties hereto have executed this Second Addendum as of the day and year first above written. 

 

									
	“LANDLORD”	 		 	“TENANT”
			
	MAIN STREET EAST, LLC	 		 	METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
					
	By:	 	/s/ Frederick O. Brown	 		 	By:	 	/s/ Stephen Benoit 
					
	Its:	 	Member	 		 	Its:	 	Chief Executive Officer

  
 3 

 THIRD ADDENDUM TO LEASE AGREEMENT 

THIS THIRD ADDENDUM TO LEASE AGREEMENT, is made effective this 16th day of December, 2015, by and between MAIN STREET EAST, LLC, A
Michigan limited liability company, (“Landlord”), and METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC, a Delaware limited liability company (“Tenant”), in the manner following: 

RECITALS 
 WHEREAS,
the parties are Landlord and Tenant pursuant to a Lease Agreement dated November 30, 2009, as amended by an Addendum to Lease Agreement dated October 31, 2011, and as amended by a Second Addendum dated December 16, 2014 (as amended,
the “Lease”) whereby Tenant leased from Landlord approximately 4,076 square feet of office space located in the north portion of the fourth floor of the Haymarket Building – 161 East Michigan Avenue in Kalamazoo, MI (the “Leased
Premises”). 
 NOW THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, it is
expressly agreed by and between the parties hereto as follows: 
  

	 	1.	 The Lease shall be extended on a
Month-to-Month basis, commencing January 1, 2016 (the “Extension Term”). Whereas both Landlord and Tenant have the right to terminate the Lease Agreement
with thirty (30) days advanced written notice. 

  

	 	2.	 Tenant agrees to pay a rental amount of $5,196.28 per month during the Extension Term. 

 

	 	3.	 Right of First Refusal – Tenant shall have the right to match any offers submitted for the Leased
Premises (with or without the “cube farm”, as defined below) within thirty days of written notice from Landlord. Tenant shall provide a letter stipulating acceptance or rejection of the new Lease Terms. 

 

	 	4.	 Nullification of Right of First Refusal – After March 31, 2016, in the event the Landlord
receives an offer for the entire 4th floor, the Right of First Refusal shall be deemed null and void – allowing the Landlord to freely Lease the entire 4th floor to a third party. Landlord must provide Tenant thirty (30) days advanced written notice in such an event. 

 

	 	5.	 Tenant may exercise any one of the following options anytime during the Month-to-Month Extension period, but prior to any Right of First Refusal notification from Landlord, subject to the terms and conditions set forth herein: 

 

	 	•	 	 Option A – Exercise Renewal on Current Space. Tenant may exercise an option to
renew the Lease for a one (1) year term on the current Leased Premises at the rental rates set forth in the “Option Term” chart below (the “Option Term Rates”). 

 

	 	•	 	 Option B – Exercise Renewal on Downsized Space. Tenant may exercise an option to
renew the Lease for a one (1) year term on downsized space. Such option would reduce the square footage of the Leased Premises from approximately 4,076 square feet to approximately 3,088 square feet via elimination of approximately 988 square
feet known as the “cube farm”. In order to exercise such option, Tenant must provide thirty (30) days advance written of its intent 

	 	 
to do so. In this event, the rental amount for the Leased Premises shall be reduced accordingly, based on the Option Term Rates. 

 

			
	Dates	 	Rate/Square Foot
		
	 Option Term
	 	
		
	 January 1, 2016-December 31, 2016
	 	$15.76
		
	 January 1, 2017-December 31, 2017
	 	$16.23

  

	 	6.	 Any inconsistencies between the Lease and this Addendum shall be resolved in favor of this Addendum. Except as
expressly amended herein, the terms, covenants and conditions of the Lease are hereby ratified, affirmed and in full force and effect. 

IN WITNESS WHEREOF, the parties hereto have executed this Third Addendum as of the day and year first above written. 

 

									
	“LANDLORD”	 		 	“TENANT”
			
	MAIN STREET EAST, LLC	 		 	METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
					
	By:	 	/s/ Frederick O. Brown	 		 	By:	 	/s/ Stephen Benoit 
					
	Its:	 	Member	 		 	Its:	 	Chief Executive Officer

  
 2 

 FOURTH ADDENDUM TO LEASE AGREEMENT 

THIS FOURTH ADDENDUM TO LEASE AGREEMENT is made effective this 29th day of April, 2016,
by and between MAIN STREET EAST, LLC, a Michigan limited liability company (“Landlord”), and METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC, a Delaware limited liability company (“Tenant”), in the manner
following: 
 RECITALS 

WHEREAS, the parties are Landlord and Tenant pursuant to a Lease Agreement dated November 30, 2009, as amended by an Addendum to Lease
Agreement dated October 31, 2011, a Second Addendum dated December 16, 2014, and a Third Addendum dated December 16, 2015 (as amended, collectively, the “Lease”), whereby Tenant leased from Landlord approximately 4,076
square feet of office space located in the north portion of the fourth floor of the Haymarket Building – 161 East Michigan Avenue in Kalamazoo, MI (the “Leased Premises”); and 

WHEREAS, the parties now desire (i) to reduce the area of the Leased Premises to approximately 2,901 square feet and (ii) to extend
the term of the Lease by three years, all pursuant to the terms and conditions of this Fourth Addendum; 
 NOW THEREFORE, for good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, it is expressly agreed by and between the parties hereto as follows: 
  

	 	1.	 Leased Premises. The Leased Premises shall be approximately 2,216 square feet of office space and the
corresponding portion, 45.64%, of common space at 685 square feet, totaling 2,901 square feet known as “Suite A”, as depicted on Exhibit “A” attached hereto. 

 

	 	2.	 Term. The Lease shall be extended by three (3) years, commencing May 1, 2016, and terminating
April 30, 2019 (the “Extension Term”). 

  

	 	3.	 Rental. Tenant agrees to pay the following monthly rental amounts over the Extension Term:

  

	 	•	 	 May 1, 2016 – April 30, 2017
                    $3,810                    
($15.760/sqft) 

  

	 	•	 	 May 1, 2017 – April 30, 2018
                    $3,888                    
($16.082/sqft 

  

	 	•	 	 May 1, 2018 – April 30, 2019
                    $3,964                    
($16.397/sqft) 

  

	 	4.	 Relocation. 

  

	 	A.	 Landlord, at any time during the Extension Term, shall have the right to relocate Tenant from the Leased
Premises (for purposes of this Section, the “Old Premises”) to other space in Landlord’s downtown Kalamazoo portfolio (such other space being referred to as the “New Premises”) (the “Relocation Option”).

  

	 	B.	 Landlord shall have the right to exercise the Relocation Option only by giving notice thereof (the
“Relocation Notice”) to Tenant not later than ninety (90) days before the date that the relocation becomes effective (the “Relocation Date”). A Relocation Notice shall not be effective unless Landlord includes
therewith a floor plan identifying the New Premises. The New Premises shall (i) be comprised of rentable area equal to or greater than the rentable area of the Old Premises, (ii) be similar in configuration to the Old Premises, and
(iii) be within a 3 block radius of the Old Premises. In no event shall the monthly rental amount increase if the New Premises is comprised of a rentable area greater than the rentable area of the Old Premises. Landlord, at Landlord’s
expense, shall construct in the New Premises, not later than the 

	 	
Relocation Date, an interior installation that is as comparable as reasonably practicable to the interior installation that then exists in the Old Premises. 

 

	 	C.	 Tenant shall cooperate reasonably with Landlord in connection with Landlord’s designing and performing the
construction of such interior installation in the New Premises. Tenant shall vacate the Old Premises and surrender vacant and exclusive possession of the Old Premises to Landlord on or before the Relocation Date, provided that Landlord has
theretofore delivered vacant and exclusive possession of the New Premises to Tenant. Landlord shall reimburse Tenant for any reasonable moving expenses and for any other reasonable costs and expenses incurred by Tenant in so relocating to the New
Premises from the Old Premises, within thirty (30) days after Tenant’s request therefor and Tenant’s submission to Landlord of reasonable supporting documentation therefor. 

 

	 	D.	 From and after the Relocation Date, all references to the Premises herein shall mean the New Premises rather
than the Old Premises. 

  

	 	5.	 Any inconsistencies between the Lease and this Addendum shall be resolved in favor of this Addendum. Except as
expressly amended herein, the terms, covenants and conditions of the Lease are hereby ratified, affirmed and in full force and effect. 

IN WITNESS WHEREOF, the parties hereto have executed this Fourth Addendum as of the day and year first above written. 

 

									
	“LANDLORD”	 		 	“TENANT”
			
	MAIN STREET EAST, LLC	 		 	METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
					
	By:	 	/s/ Frederick O. Brown	 		 	By:	 	/s/ Stephen Benoit
	Name:	 	Frederick O. Brown	 		 	Name:	 	Stephen Benoit
	Its:	 	Authorized Agent	 		 	Its:	 	CEO

  
 2

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