Document:

EX-10.14

 Exhibit 10.14 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”) is made and entered into as of January 24, 2020 by and
between Beam Therapeutics Inc. (the “Company”) and Giuseppe (“Pino”) Ciaramella (the “Executive”), and is effective as of the day prior to the date on which the Company becomes subject to the reporting
obligations of Section 12 of the Securities Exchange Act of 1934, as amended (the “Effective Date”). 
 WHEREAS, the
Company has employed the Executive pursuant to that certain Employment Agreement by and between the Company and the Executive, dated as of February 2, 2018 (the “Prior Employment Agreement”); and 

WHEREAS, the Company and Executive desire to enter into this Agreement, which will supersede the Prior Employment Agreement as of the
Effective Date, setting forth the terms and conditions of Executive’s continued employment with the Company. 
 NOW, THEREFORE, in
consideration of the mutual covenants contained herein and intending to be legally bound hereby, the Company and the Executive agree as follows: 

1.    Position and Duties. 

(a)    Effective as of the Effective Date, the Executive will be employed by the Company, on a full-time basis, as its
President and Chief Scientific Officer. In addition, the Executive may be asked from time to time to serve as a director or officer of one or more of the Company’s Affiliates, without further compensation. 

(b)    The Executive agrees to perform the duties of his position and such other duties as may reasonably be assigned to
the Executive from time to time. The Executive also agrees that, while employed by the Company, he will devote his full business time and his best efforts, business judgment, skill and knowledge exclusively to the advancement of the business
interests of the Company and its Affiliates and to the discharge of his duties and responsibilities for them. 

(c)    The Executive agrees that, while employed by the Company, he will comply with all Company policies, practices and
procedures and all codes of ethics or business conduct applicable to his position, as in effect from time to time. 

2.    Compensation and Benefits. During the Executive’s employment hereunder, as compensation for all services
performed by the Executive for the Company and its Affiliates, the Company will provide the Executive the following compensation and benefits: 

(a)    Base Salary. The Company will pay the Executive a base salary at the rate of $475,000 per year, payable in
accordance with the regular payroll practices of the Company and subject to adjustment from time to time by the Board of Directors of the Company (the “Board”) in its discretion (as adjusted, from time to time, the “Base
Salary”). 

  
 -1- 

 (b)    Bonus Compensation. For each fiscal year completed during
the Executive’s employment under this Agreement, the Executive will be eligible to earn an annual bonus (each, an “Annual Bonus”). The Executive’s target bonus will be 45% of the Base Salary, with the actual amount of any
such Annual Bonus to be determined by the Board in its discretion, based on the Executive’s performance and the Company’s performance against goals established by the Compensation Committee of the Board. In order to receive any Annual
Bonus hereunder, the Executive must be employed through the date that such Annual Bonus is paid. 

(c)    Participation in Employee Benefit Plans. The Executive will be entitled to participate in all employee
benefit plans from time to time in effect for employees of the Company generally, except to the extent such plans are duplicative of benefits otherwise provided to the Executive under this Agreement (e.g., a severance pay plan). The Executive’s
participation will be subject to the terms of the applicable plan documents and generally applicable Company policies, as the same may be in effect from time to time, and any other restrictions or limitations imposed by law. 

(d)    Vacations. The Executive will be entitled to earn vacation days in accordance with the policies of the
Company, as in effect from time to time. Vacation may be taken at such times and intervals as the Executive shall determine, subject to the business needs of the Company. 

(e)    Business Expenses. The Company will pay or reimburse the Executive for all reasonable business expenses
incurred or paid by the Executive in the performance of his duties and responsibilities for the Company, subject to any maximum annual limit and other restrictions on such expenses set by the Company and to such reasonable substantiation and
documentation as may be specified by the Company from time to time. The Executive’s right to payment or reimbursement hereunder shall be subject to the following additional rules: (i) the amount of expenses eligible for payment or
reimbursement during any calendar year shall not affect the expenses eligible for payment or reimbursement in any other calendar year, (ii) payment or reimbursement shall be made not later than December 31 of the calendar year following
the calendar year in which the expense or payment was incurred and (iii) the right to payment or reimbursement shall not be subject to liquidation or exchange for any other benefit. 

3.    Confidential Information and Intellectual Property. 

(a)    Confidential Information. During the course of the Executive’s employment with the Company, the
Executive will learn of Confidential Information, and will develop Confidential Information on behalf of the Company and its Affiliates. The Executive agrees that he will not use or disclose to any Person (except as required by applicable law or for
the proper performance of his regular duties and responsibilities for the Company) any Confidential Information obtained by the Executive incident to his employment or any other association with the Company or any of its Affiliates. The Executive
agrees that this restriction will continue to apply after his employment terminates, regardless of the reason for such termination. For the avoidance of doubt, (i) nothing contained in this Agreement limits, restricts

  
 -2- 

 
or in any other way affects the Executive’s communicating with any governmental agency or entity, or communicating with any official or staff person of a governmental agency or entity,
concerning matters relevant to such governmental agency or entity and (ii) the Executive will not be held criminally or civilly liable under any federal or state trade secret law for disclosing a trade secret (y) in confidence to a
federal, state, or local government official, either directly or indirectly, or to an attorney, solely for the purpose of reporting or investigating a suspected violation of law, or (z) in a complaint or other document filed under seal in a
lawsuit or other proceeding; provided, however, that notwithstanding this immunity from liability, the Executive may be held liable if he unlawfully accesses trade secrets by unauthorized means. 

(b)    Protection of Documents. All documents, records and files, in any media of whatever kind and description,
relating to the business, present or otherwise, of the Company or any of its Affiliates, and any copies, in whole or in part, thereof (the “Documents”), whether or not prepared by the Executive, shall be the sole and exclusive
property of the Company. The Executive agrees to safeguard all Documents and to surrender to the Company, at the time his employment terminates or at such earlier time or times as the Board or its designee may specify, all Documents then in his
possession or control. The Executive also agrees to disclose to the Company, at the time his employment terminates or at such earlier time or times as the Board or its designee may specify, all passwords necessary or desirable to obtain access to,
or that would assist in obtaining access to, any information which the Executive has password-protected on any computer equipment, network or system of the Company or any of its Affiliates. 

(c)    Assignment of Rights to Intellectual Property. 

(i)    The Executive will promptly disclose in confidence to the Company all inventions, discoveries, ideas, processes,
products, computer programs, works of authorship and know-how that the Executive or any individual working with the Executive makes, conceives or reduces to practice, from the date the Executive’s
employment with the Company commenced through the expiration or termination of this Agreement, and that (i) arises from the services provided by the Executive to the Company (the “Services”) or other work performed by the
Executive for the Company or (ii) arises from use of facilities, equipment, supplies, materials or Confidential Information of the Company (along with all patent and other intellectual property rights arising therefrom, collectively,
“Developments”). For clarity, “Developments” will include any products, progeny, modifications, improvements or derivatives of biological materials provided to the Executive by the Company. The Executive will not
make any use of any funds, space, personnel, facilities, equipment or other resources of a third party in performing the Services hereunder nor take any other action that would result in another third party owning or having a right in any
Developments under the such third party’s applicable policies or otherwise. 
 (ii)    The Executive will make and
maintain adequate and reasonably current written records of all Developments, which records will be available to and remain the property of the Company at all times. All Developments will be the sole property of the Company. For purposes of the
copyright laws of the United States, all Developments will constitute works made for hire as applicable. The Executive hereby assigns and, to the extent any such assignment cannot be made at present, hereby agrees to assign to the Company, without
further compensation, all right, title and interest in and to all Developments. 

  
 -3- 

 (iii)    The Executive will assist the Company in any reasonable manner
to obtain for its own benefit patent and other intellectual property rights in any and all countries with respect to the Developments, and the Executive will execute and deliver, promptly as requested, patent and other applications and assignments
therefor. The Executive will further reasonably assist the Company to enforce any such patent rights and other rights, including testifying in any suit or proceeding. The Executive will perform the Executive’s obligations under this
Section 3 without further compensation, except for reimbursement of expenses incurred at the Company’s request and, with respect to any performance after the term of this Agreement or in excess of the Executive’s time commitment
during the term of this Agreement, compensation at a reasonable rate for costs and expenses incurred by the Executive and time actually spent by the Executive at the Company’s request. In the event the Company is unable after reasonable effort
to obtain the Executive’s signature on any document which the Executive may be required to sign pursuant to this Section 3, whether because of the Executive’s physical or mental incapacity or for any other reason whatsoever, the
Executive hereby irrevocably appoints each of the President and the Secretary of the Company (whether now or hereafter in office) as the Executive’s
attorney-in-fact to execute any such document on the Executive’s behalf. 

(iv)    The Company agrees that any technology and/or intellectual property, and any and all intellectual property
rights, industrial property rights, and moral rights thereto, created in whole or in part by the Executive prior to the date hereof and referred to in Exhibit A to this Agreement (“Excluded Technology”) is
not within the scope of the assignment of Developments hereunder, which may be updated in the future by mutual agreement. Except for any Excluded Technology, if the Executive incorporates into any Developments any proprietary information or other
intellectual property owned by the Executive or in which the Executive has an interest, the Executive hereby grants, and to the extent any such grant cannot be made at the present, agrees to grant to the Company a
non-exclusive, royalty-free, irrevocable, perpetual, transferable worldwide license, with the right to sublicense through multiple tiers, under all intellectual property rights, to make, use, refrain from
using, sell, offer for sale, import, modify, delete, add to, reproduce, create derivative works based upon, distribute, perform, display or otherwise exploit in any way, such proprietary information or other intellectual property, in whole or in
part, by any means, now known or later developed, in all languages 
 4.    Termination of Employment. The
Executive’s employment under this Agreement shall continue until terminated pursuant to this Section 4. 

(a)    By the Company For Cause. The Company may terminate the Executive’s employment for Cause upon notice to
the Executive setting forth in reasonable detail the nature of the Cause. For purposes of this Agreement, “Cause” shall mean the occurrence of any of the following, as determined by the Board in its reasonable judgment: (i) a
willful and material act of dishonesty by the Executive in connection with the performance of the Executive’s duties as an employee of the Company; (ii) the Executive’s conviction of, or plea of guilty or nolo contendere to, a felony
or any crime involving fraud, embezzlement or any willful act of moral turpitude, or a material violation of a federal or state law by the Executive, that the Board reasonably determines has had or is reasonably likely to have a materially
detrimental effect on the Company’s reputation or business; (iii) the Executive’s gross misconduct in the performance of the Executive’s duties as an employee of the Company; (iv) the Executive’s willful and material
unauthorized use or disclosure of any proprietary information or trade secrets of the Company that materially damages 

  
 -4- 

 
the Company or any other party to whom the Executive owes an obligation of nondisclosure as a result of the Executive’s relationship with the Company; (v) the Executive’s willful
and material breach of any obligations under any written agreement or covenant with the Company, including this Agreement; or (vi) the Executive’s continued willful and substantial failure to perform the Executive’s employment duties
(other than a result of the Executive’s death or Disability) after notice. Cause shall not exist unless, in any case, the Executive has first received a written notice from the Board that sets forth the factual basis for the Board’s
determination as to any behavior or occurrence claimed as Cause and the Executive fails to cure such claimed behavior or occurrence, if curable, to the reasonable satisfaction of a majority of the Board within ten (10) business days after
receiving such written notice, in which case the Executive’s termination date will be the expiration date of the cure period, if any. For purposes of this paragraph, no act or failure to act on the Executive’s part shall be considered
“willful” unless it is done or omitted to be done by the Executive in bad faith and without reasonable belief that the act or failure to act was in the best interest of the Company. 

(b)    By the Company Without Cause. The Company may terminate the Executive’s employment at any time other
than for Cause upon notice to the Executive. 
 (c)    By the Executive for Good Reason. The Executive may
terminate his employment for Good Reason, provided that (i) the Executive provides written notice to the Company, setting forth in reasonable detail the nature of the condition giving rise to Good Reason, within sixty (60) days of the
initial existence of such condition, (ii) the condition remains uncured by the Company for a period of thirty (30) days following such notice and (iii) the Executive terminates his employment, if at all, not later than sixty
(60) days after the expiration of such cure period. For purposes of this Agreement, “Good Reason” shall mean (i) a material reduction in the Executive’s base salary or target annual bonus; (ii) a material
diminution of the Executive’s title, duties, responsibilities or reporting lines; (iii) a material change in the principal geographic location at which the Executive must perform services, more than fifty (50) miles from the
Company’s head office; or (iv) a material breach by the Company of this Agreement or any equity award agreement with the Executive. 

(d)    By the Executive Without Good Reason. The Executive may terminate his employment without Good Reason at any
time upon thirty (30) days’ notice to the Company. The Board may elect to waive such notice period or any portion thereof. 

(e)    Death and Disability. The Executive’s employment hereunder shall automatically terminate in the event
of the Executive’s death during employment. The Company may terminate the Executive’s employment, upon notice to the Executive, in the event of the Executive’s Disability. 

5.    Other Matters Related to Termination; Change in Control. 

(a)    Final Compensation. In the event of termination of the Executive’s employment with the Company,
howsoever occurring, the Company shall pay the Executive (i) the Base Salary for the final payroll period of his employment, through the date his employment terminates; (ii) compensation at the rate of the Base Salary for any vacation time
earned but not used as of the date his employment terminates; and (iii) reimbursement, in accordance with Section 

  
 -5- 

 
2(e) hereof, for business expenses incurred by the Executive but not yet paid to the Executive as of the date his employment terminates, provided that the Executive submits all expenses and
supporting documentation required within sixty (60) days of the date his employment terminates, and provided further that such expenses are reimbursable under Company policies then in effect (all of the foregoing, “Final
Compensation”). Except as otherwise provided in Section 5(a)(iii), Final Compensation will be paid to the Executive within thirty (30) days following the date of termination or such shorter period required by law. 

(b)    Severance Benefits. In the event of a termination of the Executive’s employment pursuant to
Section 4(b) or Section 4(c) above, the Company will pay the Executive, in addition to Final Compensation: (i) the Base Salary for a period of twelve (12) months following the date of termination; (ii) a lump sum target
Annual Bonus, pro-rated for the portion of the then-current calendar year during which the Executive was employed by the Company including any notice periods; (iii) continued vesting for twelve
(12) months of any unvested portion of any equity awards then held by the Executive, and (iv) provided that the Executive timely elects and remains eligible for coverage pursuant to Part 6 of Title I of ERISA, or similar state law
(collectively, “COBRA”), payment or reimbursement to the Executive of an amount equal to the full monthly premium for COBRA continuation coverage under the Company’s medical plans as in effect on the date of the
Executive’s termination with respect to the level of coverage in effect for the Executive and the Executive’s eligible dependents as of the date of the Executive’s termination, on a monthly basis, with respect to the period from the
date of the Executive’s termination until the earlier of (x) twelve (12) months following such date and (y) the date the Executive becomes eligible for coverage under a subsequent employer’s medical plan (together, the
“Severance Benefits”). 
 (c)    Change in Control. In the event of a Change in Control, fifty
percent (50%) of the Executive’s unvested equity awards then held by the Executive (but excluding the portion of such equity awards that would otherwise have vested during the six-month period after the
date of such Change in Control (the “Carved Out Equity”)) will become fully vested and exercisable and no longer subject to any restrictions or forfeiture upon such Change in Control. The remaining fifty percent (50%) of the
unvested equity awards shall, subject to all applicable conditions and restrictions, continue to vest following the Change in Control in accordance with the vesting schedule in effect prior to the Change in Control. The Carved Out Equity shall,
subject to the Executive’s continued employment with the Company or its successor after such Change in Control, continue to vest over the first six months after the date of the Change in Control in accordance with the vesting schedule in effect
prior to the Change in Control. In the event of a termination of the Executive’s employment pursuant to Section 4(b) or Section 4(c) above within twelve (12) months immediately following or within thirty (30) days
immediately prior to a Change in Control, then, in addition to the Final Compensation and in lieu of the Severance Benefits, the Company shall provide the following payments and benefits: (i) the Base Salary for a period of twelve
(12) months following the date of termination; (ii) an amount equal to the target Annual Bonus; (iii) immediate vesting of any unvested portion of any equity awards then held by the Executive; and (iv) provided that the Executive
timely elects and remains eligible for COBRA coverage, payment or reimbursement to the Executive of an amount equal to the full monthly premium for COBRA continuation coverage under the Company’s medical plans as in effect on the date of the
Executive’s termination with respect to the level of coverage in effect for the Executive and the Executive’s eligible dependents as of the date of the Executive’s termination, 

  
 -6- 

 
on a monthly basis, with respect to the period from the date of the Executive’s termination until the earlier of (x) twelve (12) months following such date and (y) the date the
Executive becomes eligible for coverage under a subsequent employer’s medical plan (together, the “CIC Severance Benefits”). 

(d)    Conditions To And Timing Of Severance Benefits. Any obligation of the Company to provide the Executive the
Severance Benefits or the CIC Severance Benefits, as applicable, is conditioned on his signing and returning, without revoking, to the Company a timely and effective separation agreement containing a general release of claims and other customary
terms in the form provided to the Executive by the Company at the time that the Executive’s employment terminates (the “Separation Agreement”). The Separation Agreement must become effective, if at all, by the sixtieth (60th)
calendar day following the date the Executive’s employment terminates. Any Severance Benefits or CIC Severance Benefits to which the Executive is entitled will be payable in the form of salary continuation in accordance with the normal payroll
practices of the Company. The first such payment will be made on the Company’s next regular payday following the expiration of sixty (60) calendar days from the date that the Executive’s employment terminates, but will be retroactive
to the day following such date of termination. 
 (e)    Benefits Termination. Except for any right the Executive
may have under COBRA to continue participation in the Company’s group health and dental plans at his cost, the Executive’s participation in all employee benefit plans shall terminate in accordance with the terms of the applicable benefit
plans based on the date of termination of his employment, without regard to any continuation of the Base Salary or other payment to the Executive following termination of his employment, and the Executive shall not be eligible to earn vacation or
other paid time off following the termination of his employment. 
 (f)    Survival. Provisions of this Agreement
shall survive any termination of employment if so provided in this Agreement or if necessary or desirable to accomplish the purposes of other surviving provisions, including without limitation the Executive’s obligations under Section 3 of
this Agreement. The obligation of the Company to make payments to the Executive under Section 5(b), and the Executive’s right to retain the same, are expressly conditioned upon his continued full performance of his obligations under
Section 3 of this Agreement. Upon termination by either the Executive or the Company, all rights, duties and obligations of the Executive and the Company to each other shall cease, except as otherwise expressly provided in this Agreement. 

6.    Timing of Payments and Section 409A. 

(a)    Notwithstanding anything to the contrary in this Agreement, if at the time the Executive’s employment
terminates, the Executive is a “specified employee,” as defined below, any and all amounts payable under this Agreement on account of such separation from service that would (but for this provision) be payable within six (6) months
following the date of termination, shall instead be paid on the next business day following the expiration of such six (6)-month period or, if earlier, upon the Executive’s death; except (A) to the extent of amounts that do not constitute
a deferral of compensation within the meaning of Treasury regulation Section 1.409A-1(b) (including without limitation by reason of the safe harbor set forth in Section 1.409A-1

  
 -7- 

 
(b)(9)(iii), as determined by the Company in its reasonable good faith discretion); (B) benefits which qualify as excepted welfare benefits pursuant to Treasury regulation Section 1.409A-1(a)(5); or (C) other amounts or benefits that are not subject to the requirements of Section 409A of the Code (“Section 409A”). 

(b)    For purposes of this Agreement, all references to “termination of employment” and correlative phrases
shall be construed to require a “separation from service” (as defined in Section 1.409A-1(h) of the Treasury regulations after giving effect to the presumptions contained therein), and the term
“specified employee” means an individual determined by the Company to be a specified employee under Treasury regulation Section 1.409A-l(i). 

(c)    Each payment made under this Agreement shall be treated as a separate payment and the right to a series of
installment payments under this Agreement is to be treated as a right to a series of separate payments. 
 (d)    In no
event shall the Company have any liability relating to the failure or alleged failure of any payment or benefit under this Agreement to comply with, or be exempt from, the requirements of Section 409A. 

7.    Definitions. For purposes of this Agreement, the following definitions apply: 

“Affiliates” means all persons and entities directly or indirectly controlling, controlled by or under common control with
the Company, where control may be by management authority, equity interest or otherwise. 
 “Change in Control” means the
consummation of (i) the dissolution or liquidation of the Company; (ii) the sale of all or substantially all of the assets of the Company on a consolidated basis to an unrelated person or entity; (iii) a merger, reorganization or
consolidation pursuant to which the holders of the Company’s outstanding voting power immediately prior to such transaction do not own a majority of the outstanding voting power of the surviving or resulting entity (or its ultimate parent, if
applicable); (iv) the acquisition of all or a majority of the outstanding voting stock of the Company in a single transaction or a series of related transactions by a Person or group of Persons; or (v) any other acquisition of the business of
the Company, as determined by the Board; provided, however, that the Company’s Initial Public Offering, any subsequent public offering or anther capital raising event, or a merger effected solely to change the Company’s
domicile shall not constitute a “Change in Control”. 
 “Code” means the Internal Revenue Code of 1986, as
amended. 
 “Confidential Information” means any and all information of the Company and its Affiliates that is not
generally available to the public. Confidential Information also includes any information received by the Company or any of its Affiliates from any Person with any understanding, express or implied, that it will not be disclosed. Confidential
Information does not include information that enters the public domain, other than through the Executive’s breach of his obligations under this Agreement or any other agreement between the Executive and the Company or any of its Affiliates.

 “Disability” means “disability” as defined in Section 422 of the Code. 

  
 -8- 

 “Initial Public Offering” means the consummation of the first firm
commitment underwritten public offering pursuant to an effective registration statement under the Securities Act of 1933, as amended, covering the offer and sale by the Company of its equity securities, as a result of or following which the common
stock of the Company shall be publicly held. 
 “Intellectual Property” means inventions, discoveries, developments,
methods, processes, compositions, works, concepts and ideas (whether or not patentable or copyrightable or constituting trade secrets) conceived, made, created, developed or reduced to practice by the Executive (whether alone or with others, whether
or not during normal business hours or on or off Company premises) during the Executive’s employment that relate either to the business of the Company or any of its Affiliates or to any prospective activity of the Company or any of its
Affiliates or that result from any work performed by the Executive for the Company or any of its Affiliates or that make use of Confidential Information or any of the equipment or facilities of the Company or any of its Affiliates. 

“Person” means an individual, a corporation, a limited liability company, an association, a partnership, an estate, a trust
or any other entity or organization, other than the Company or any of its Affiliates. 
 8.    Indemnification.
The Company shall indemnify and hold the Executive harmless to the fullest extent provided under the Certificate of Incorporation and the By-Laws of the Company against and in respect of any and all actions,
suits, proceedings, claims, demands, judgments, costs, expenses (including reasonable attorney’s fees), losses, and damages resulting from the Executive’s good faith performance of his duties and obligations to the Company, subject to the
limitations and conditions set forth therein. 
 9.    Conflicting Agreements. The Executive hereby represents
and warrants that his signing of this Agreement and the performance of his obligations under it will not breach or be in conflict with any other agreement to which the Executive are a party or are bound, and that the Executive is not now subject to
any covenants against competition or similar covenants or any court order that could affect the performance of his obligations under this Agreement. The Executive agrees that the Executive will not disclose to or use on behalf of the Company any
confidential or proprietary information of a third party without that party’s consent. 

10.    Withholding. All payments made by the Company under this Agreement shall be reduced by any tax or other
amounts required to be withheld by the Company to the extent required by applicable law. 
 11.    Assignment.
Neither the Executive nor the Company may make any assignment of this Agreement or any interest in it, by operation of law or otherwise, without the prior written consent of the other; provided, however, the Company may assign its
rights and obligations under this Agreement without the Executive’s consent to one of its Affiliates or to any Person with whom the Company shall hereafter effect a reorganization, consolidate or merge, or to whom the Company shall hereafter
transfer all or substantially all of its properties or assets. This Agreement shall inure to the benefit of and be binding upon the Executive and the Company, and each of their respective successors, executors, administrators, heirs and permitted
assigns. 

  
 -9- 

 12.    Severability. If any portion or provision of this
Agreement shall to any extent be declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so
declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 

13.    Miscellaneous. This Agreement sets forth the entire agreement between the Executive and the Company, and
replaces all prior and contemporaneous communications, agreements and understandings, written or oral, with respect to the terms and conditions of the Executive’s employment, including the Prior Employment Agreement and the Amended and Restated
Employment Agreement by and between the Company and the Executive, dated as of September 25, 2019. This Agreement may not be modified or amended, and no breach shall be deemed to be waived, unless agreed to in writing by the Executive and an
expressly authorized representative of the Board. The headings and captions in this Agreement are for convenience only and in no way define or describe the scope or content of any provision of this Agreement. This Agreement may be executed in two or
more counterparts, each of which shall be an original and all of which together shall constitute one and the same instrument. This is a Massachusetts contract and shall be governed and construed in accordance with the laws of the Commonwealth of
Massachusetts, without regard to any conflict of laws principles that would result in the application of the laws of any other jurisdiction. 

14.    Notices. Any notices provided for in this Agreement shall be in writing and shall be effective when
delivered in person or deposited in the United States mail, postage prepaid, and addressed to the Executive at his last known address on the books of the Company or, in the case of the Company, to it at its principal place of business, attention of
the Chairman of the Board, or to such other address as either party may specify by notice to the other actually received. 
 IN WITNESS
WHEREOF, this Agreement has been executed by the Company, by its duly authorized representative, and by the Executive, as of the date first above written. 
  

									
	THE EXECUTIVE:	 		 	THE COMPANY:
				
	 /s/ Giuseppe Ciaramella
	 		 	By:	 	 /s/ John Evans

	Giuseppe (“Pino”) Ciaramella	 		 		 	Name:	 	John Evans
		 		 		 	Title:	 	Chief Executive Officer

  
 -10- 

 EXHIBIT A 

Excluded Technology 

  
 -11-EX-10.15

 Exhibit 10.15 

Beam Therapeutics Inc. 
 January 24,
2020 
 Terry-Ann Burrell 

Dear Terry-Ann, 

This letter agreement (this “Agreement”) confirms the terms and conditions of your employment with Beam Therapeutics Inc.
(the “Company”), effective as of the day prior to the date on which the Company becomes subject to the reporting obligations of Section 12 of the Securities Exchange Act of 1934, as amended (the “Effective
Date”). 
 1.    Position. Your position with the Company will be Chief Financial Officer (CFO). You
agree to perform the duties of your position and such other duties as may be assigned to you from time to time by the Company. You will report to the Chief Executive Officer of the Company. You will be expected to devote your full business time and
your best professional efforts to the performance of your duties and responsibilities for the Company and its affiliates and to abide by all policies, practices and procedures of the Company and all codes of ethics or business conduct applicable to
your position, as in effect from time to time. As this is a full-time role, it is understood and agreed that you will not engage in additional employment, consulting or other business activities (whether full-time or part-time) without prior written
consent. 
 2.    Salary. The Company will pay you an annual base salary of $400,000 payable in accordance with
the Company’s standard payroll schedule (“Base Salary”). This salary will be subject to periodic review and adjustments at the discretion of the Compensation Committee (the “Committee”) of the Board of
Directors of the Company (the “Board”). 
 3.    Bonus Eligibility. You are eligible to receive
an annual performance bonus with a target of 40% of your Base Salary. The actual amount of your annual performance bonus will be determined by the Committee in its discretion and will be subject to the Committee’s assessment of your
performance, as well as business conditions at the Company. As a condition to receiving any such bonus, you must continue to be employed with the Company through the date that such bonus is to be paid. For 2019, your bonus is guaranteed in full and
will not be subject to pro-ration. 

  
 1 

 4.    Benefits; Expense Reimbursement; Commuter Expenses. 

(a)    You will be eligible to participate in such benefits programs as the Company shall maintain from time to time in
accordance with the terms of such plans to the same extent as, and subject to the same terms, conditions and limitations applicable to, other employees of the Company of similar rank and tenure. 

(b)    In accordance with the Company’s policies and procedures, you will be entitled to reimbursement of all
reasonable and properly documented expenses incurred by you in the performance of your duties that are approved by the Company. 

(c)    The Company will not require you to relocate permanently to the Cambridge, Massachusetts area and shall reimburse
you for all reasonable and properly documented commuting expenses and reasonable housing accommodations incurred by you in connection with your commute to Cambridge, Massachusetts from New York. The Company will also furnish you will short-term
temporary housing for the first three (3) months of your employment with the Company. All payments contemplated by this Section 5(c) are subject to legally required tax withholdings. All taxable reimbursed expenses will be included in your
income and will be grossed up accordingly. 
 5.    Representation Regarding Other Obligations. As a condition of
your employment, you entered into an Employee Non-Solicitation, Confidentiality and Assignment Agreement between you and the Company, dated June 24, 2019 (the “the Employee Non-Solicitation, Confidentiality and Assignment Agreement”), which shall remain in full force and effect following the Effective Date. You represent that you are not subject to any confidentiality, non-competition or other agreement that restricts your employment activities or that may affect the performance of your obligations to the Company under this Agreement. You further represent that you have not used
and agree that you will not use or disclose on behalf of the Company any trade secret or other confidential or proprietary information of any previous employer or any other party without that party’s consent. 

6.    Taxes. All forms of compensation referred to in this Agreement are subject to reduction to reflect applicable
withholding and payroll taxes and other deductions required by law. You hereby acknowledge that the Company does not have a duty to design its compensation policies in a manner that minimizes your tax liabilities, and you will not make any claim
against the Company or the Board related to tax liabilities arising from your compensation. 
 7.    Interpretation,
Amendment and Enforcement. This Agreement and the Employee Non-Solicitation, Confidentiality and Assignment Agreement constitute the complete agreement between you and the Company, contain all the terms of
your employment with the Company and supersede any prior agreements, representations or understandings (whether written, oral or implied) between you and the Company related to the subject matter of this Agreement, including the Offer Letter by and
between you and the Company dated May 20, 2019, which as of the Effective Date shall terminate and be of no further force or effect. The terms of this Agreement and the resolution of any disputes as to the meaning, effect, performance or
validity of this 

  
 2 

 
Agreement or arising out of, related to, or in any way connected with, this Agreement, your employment with the Company or any other relationship between you and the Company (the
“Disputes”) will be governed by laws of the Commonwealth of Massachusetts, excluding laws relating to conflicts or choice of law. You and the Company submit to the exclusive personal jurisdiction of the federal and state courts
located in the Commonwealth of Massachusetts regarding any Dispute or any claim related to any Dispute. 

8.    Termination of Employment; Change in Control. It is understood that you are an
“at-will” employee. Either you or the Company may terminate the employment relationship at any time and for any reason, with or without Cause or prior notice and without additional compensation to
you, subject to the following: 
 (a)    the Company may terminate your employment for Cause (as defined below) upon
written notice to you effective immediately, in which case you will not be entitled to receive any form of payment other than your earned salary and accrued but unused vacation through your date of termination (the “Accrued
Obligations”): 
 (b)    you may terminate your employment voluntarily other than for Good Reason (as defined
below) upon at least thirty (30) days’ prior written notice to the Company, in which case you will not be entitled to receive any form of payment other than the Accrued Obligations; and 

(c)    the Company may terminate your employment without Cause upon written notice to you effective immediately, provided
and notwithstanding the foregoing, in the event that the Company terminates your employment without Cause, then, subject to you entering into and complying with a separation agreement and general release in a form provided by the Company that
becomes fully effective (due to its timely execution and non-revocation) within sixty (60) days of the termination of your employment (such requirements, the “Release Requirements”),
which may include noncompetition provisions consistent with the noncompetition provisions set forth in the Employee Non-Solicitation, Confidentiality and Assignment Agreement, in addition to Accrued
Obligations, you will be entitled to: (i) payment of an amount equal to twelve (12) months of your then Base Salary as of the date of termination, such amount to be paid in equal installments over a twelve (12) month period after the
date of your termination in accordance with the Company’s usual payroll practices and periods, and (ii) provided you timely elect and remain eligible for coverage pursuant to Part 6 of Title I of ERISA, or similar state law (collectively,
“COBRA”), payment or reimbursement to you of an amount equal to monthly COBRA premiums at the same rate as the Company pays for active employees for you and your eligible dependents until the earlier of twelve (12) months or
the date you become eligible for coverage under a subsequent employer’s medical plan, subject to applicable COBRA terms and in compliance with applicable non-discrimination or other requirements under the
Internal Revenue Code of 1986, as amended (the “Code”), the Patient Protection and Affordable Care Act, and the Health Care and Education Reconciliation Act (collectively the “Severance Payments”). In the interest
of clarity, in the event your employment is terminated as a 

  
 3 

 
result of your (1) death, (2) disability, (3) resignation, or (4) termination for Cause by the Company, you will be entitled to the Accrued Obligations but you will not be entitled
to the Severance Payments or any other compensation. 
 (d)    In the event that, within the twelve (12) month
period that immediately follows or the thirty (30) day period immediately prior to a Change in Control (as defined below), your employment with the Company is terminated by the Company without Cause or as a result of your resignation for Good
Reason, then subject to your compliance with the Release Requirements and in lieu of the Severance Payments, you will be entitled to: (1) an amount equal to twelve (12) months of your then Base Salary as of the date of termination, such
amount to be paid in equal installments over a twelve (12) month period after the date of your termination in accordance with the Company’s usual payroll practices and periods; (2) an amount equal to your target annual performance
bonus amount for the year your employment is terminated, payable within sixty (60) days following the last day of your employment; (3) provided you timely elect and remain eligible for COBRA coverage, payment or reimbursement to you of an
amount equal to monthly COBRA premiums at the same rate as the Company pays for active employees for you and your eligible dependents until the earlier of twelve (12) months or the date you become eligible for coverage under a subsequent
employer’s medical plan, subject to applicable COBRA terms and in compliance with applicable non-discrimination or other requirements under the Internal Revenue Code of 1986, as amended (the
“Code”), the Patient Protection and Affordable Care Act, and the Health Care and Education Reconciliation Act (collectively, the “CIC Severance Payments”) and (4) immediate vesting of the then unvested portion
of any outstanding equity awards then held by you (together with the CIC Severance Payments, the “CIC Severance Benefits”). In the interest of clarity, in the event your employment is terminated within the twelve (12) month
period that immediately follows or the thirty (30) day period immediately prior to a Change in Control as a result of your resignation without Good Reason or termination for Cause by the Company, you will be entitled to the Accrued
Obligations but you will not be entitled to the CIC Severance Benefits or any other compensation. 
 (e)    For purposes
of this Agreement: 
 “Cause” means: (i) your dishonest statements or acts with respect to the Company or any
affiliate of the Company, or any current or prospective customers, suppliers, vendors or other third parties with which such entity does business that results in or is reasonably anticipated to result in material harm to the Company; (ii) your
commission of (A) a felony or (B) any misdemeanor involving moral turpitude, deceit, dishonesty or fraud; (iii) your failure to perform your assigned duties and responsibilities to the reasonable satisfaction of the Company which
failure continues, in the reasonable judgment of the Company, for thirty (30) days after written notice given to you by the Company describing such failure in reasonable detail; (iv) your gross negligence, willful misconduct or
insubordination with respect to the Company that results in or is reasonably anticipated to result in harm to the Company; or (v) your material violation of any provision of any agreement between you and the Company, including this Agreement or
any agreement relating to noncompetition, non-solicitation, nondisclosure and/or assignment of inventions. 

  
 4 

 “Change in Control” means (i) any sale of the equity securities of
Company to any person or persons acting in concert after which the shareholders of the Company as of immediately prior to such sale in their capacity as such no longer own a majority of the outstanding equity securities of the Company (or its
successor); (ii) any sale of all or substantially all of the assets or capital stock of the Company (other than in a spin-off or similar transaction) or (iii) any other acquisition of the business of the
Company, as determined by the Board in its sole discretion. For the avoidance of doubt, in no event shall (i) a bona fide equity or debt financing of the Company, including a financing in which greater than 50% of the Company’s outstanding
equity securities are acquired by a third-party, or reorganization required to affect, or otherwise undertaken in connection with, an initial public offering or (ii) the acquisition of equity securities by parties not acting in concert in
connection with any public offering of the equity securities of the Company or any affiliate of the Company, be deemed a “Change in Control” for purposes of this letter. 

“Good Reason” means that you have complied with the Good Reason Process (hereinafter defined) following the occurrence of any
of the following events: (i) a material diminution in your responsibilities, authority or duties; (ii) a diminution in your Base Salary; or (iii) change of more than fifty (50) miles in the geographic location at which you
provide services to the Company (each a “Good Reason Condition”). Notwithstanding the foregoing, a suspension of your responsibilities, authority and/or duties for the Company during any portion of a bona fide internal investigation
or an investigation by regulatory or law enforcement authorities shall not be a Good Reason Condition. “Good Reason Process” shall mean that (i) you reasonably determine in good faith that a Good Reason Condition has occurred;
(ii) you notify the Company in writing of the occurrence of the Good Reason Condition within thirty (30) days of the occurrence of such condition; (iii) you cooperate in good faith with the Company’s efforts, for a period not
less than thirty (30) days following such notice (the “Cure Period”), to remedy the Good Reason Condition; (iv) notwithstanding such efforts, the Good Reason condition continues to exist; and (v) you terminate
employment within thirty (30) days after the end of the Cure Period. If the Company cures the Good Reason Condition during the Cure Period, Good Reason shall be deemed not to have occurred. 

(f)    The Severance Payments or CIC Severance Payments, as applicable, shall commence within sixty (60) days after
the date of termination of your employment hereunder and shall be made on the Company’s regular payroll dates; provided, however, that if the sixty- (60-) day period begins in one calendar year and ends
in a second calendar year, the Severance Payments or CIC Severance Payments, as applicable, shall begin to be paid in the second calendar year. In the event a regular payroll period is missed between the date of the termination of your employment
hereunder and first payment date, the first payment shall include a “catch up” payment. 
 9.    Timing of
Payments and Section 409A. 
 (a)    Notwithstanding anything to the contrary in this Agreement,
if at the time your employment terminates, you are a “specified employee,” as defined below, any and all 

  
 5 

 
amounts payable under this Agreement on account of such separation from service that would (but for this provision) be payable within six (6) months following the date of termination, shall
instead be paid on the next business day following the expiration of such six (6)-month period or, if earlier, upon your death; except (A) to the extent of amounts that do not constitute a deferral of compensation within the meaning of Treasury
regulation Section 1.409A-1(b) (including without limitation by reason of the safe harbor set forth in Section 1.409A-1 (b)(9)(iii), as determined by the
Company in its reasonable good faith discretion); (B) benefits which qualify as excepted welfare benefits pursuant to Treasury regulation Section 1.409A-1(a)(5); or (C) other amounts or benefits that
are not subject to the requirements of Section 409A of the Code (“Section 409A”). 

(b)    For purposes of this Agreement, all references to “termination of employment” and correlative phrases
shall be construed to require a “separation from service” (as defined in Section 1.409A-1(h) of the Treasury regulations after giving effect to the presumptions contained therein), and the term
“specified employee” means an individual determined by the Company to be a specified employee under Treasury regulation Section 1.409A-l(i). 

(c)    Each payment made under this Agreement shall be treated as a separate payment and the right to a series of
installment payments under this Agreement is to be treated as a right to a series of separate payments. 
 (d)    In no
event shall the Company have any liability relating to the failure or alleged failure of any payment or benefit under this Agreement to comply with, or be exempt from, the requirements of Section 409A. 

10.    Indemnification. The Company shall indemnify you and hold you harmless to the fullest extent provided under
the Certificate of Incorporation and the By-Laws of the Company against and in respect of any and all actions, suits, proceedings, claims, demands, judgments, costs, expenses (including reasonable
attorney’s fees), losses, and damages resulting from your good faith performance of your duties and obligations to the Company, subject to the limitations and conditions set forth therein. 

As of the date first written above, this Agreement will take effect as a binding agreement between you and the Company on the basis set forth
above. 
  

			
	Very truly yours,
	
	BEAM THERAPEUTICS INC.
		
	By:	 	 /s/ John Evans

	 John Evans
 Chief Executive
Officer

  
 6 

					
	Accepted and agreed:	 		 	
			
	 /s/ Terry-Ann Burrell
	 		 	January 24, 2020
	Terry-Ann Burrell	 		 	Date

  
 7

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00303-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00303-of-00352.parquet"}]]