Document:

<PAGE>

                                  EXHIBIT 10.8
                                  ------------

                          Registration Rights Agreement

<PAGE>

                          REGISTRATION RIGHTS AGREEMENT

                WHEREAS, this Registration Rights Agreement (this "AGREEMENT")
is made and entered into as of September 29, 2004, by and among Treasure
Mountain Holdings, Inc., a Nevada corporation ("PUBCO"), Spencer Trask Ventures,
Inc. ("Spencer Trask"), Rodman & Renshaw, LLC ("R&R") and purchasers signatory
hereto (each a "Purchaser" and collectively, the "PURCHASERS"); and

                WHEREAS, the Purchasers acquired from Vyteris, Inc. ("VYTERIS")
common stock and warrants to purchase shares of the common stock (collectively,
the "VYTERIS SECURITIES") in a private offering of its securities ("PRIVATE
OFFERING"), all upon the terms set forth in the Vyteris Confidential Private
Placement Memorandum dated, June 18, 2004, as amended or supplemented from time
to time, including all attachments, schedules and exhibits thereto (the
"MEMORANDUM"); and

                WHEREAS, upon consummation of the merger of Vyteris with and
into Pubco (as described in the Memorandum), Pubco shall issue Common Stock and
Warrants to the Purchasers in exchange for the Vyteris Securities purchased by
such Purchasers in the Private Offering, all upon the terms set forth in that
certain Agreement and Plan of Merger entered into by and between Pubco, a wholly
owned subsidiary of Pubco and Vyteris, dated July 8, 2004 ("MERGER AGREEMENT").

                NOW THEREFORE, Pubco and the Purchasers hereby agree as follows:

        1.      DEFINITIONS. Capitalized terms used and not otherwise defined
herein that are defined in the Merger Agreement shall have the meanings given
such terms in the Merger Agreement. As used in this Agreement, the following
terms shall have the following meanings:

                "ADVICE" shall have the meaning set forth in Section 6(d).

                "CLOSING DATE" means the date of the closing of the Private
Offering.

                "COMMISSION" means the Securities and Exchange Commission.

                "COMMON STOCK" means shares of Pubco common stock, $0.001 par
value per share, issued or issuable to Purchasers pursuant to the terms of the
Merger Agreement.

                "EFFECTIVENESS DATE" means, with respect to the Registration
Statement required to be filed hereunder, the 150th calendar day following the
Closing Date.

                "EFFECTIVENESS PERIOD" shall have the meaning set forth in
Section 2(a).

                "EXCHANGE ACT" means the Securities Exchange Act of 1934, as
amended.

                "EVENT" shall have the meaning set froth in Section 2(b).

<PAGE>

                "EVENT DATE" shall have the meaning set forth in Section 2(b).

                "FILING DATE" means, with respect to the Registration Statement
required to be filed hereunder, the 45th calendar day following the Closing
Date.

                "HOLDER" or "HOLDERS" means the holder or holders, as the case
may be, from time to time of Registrable Securities, including, without
limitation, the Placement Agents and certain officers of Pubco (as further
described in the Merger Agreement).

                "INDEMNIFIED PARTY" shall have the meaning set forth in Section
5(c).

                "INDEMNIFYING PARTY" shall have the meaning set forth in Section
5(c).

                "LOSSES" shall have the meaning set forth in Section 5(a).

                "PERSON" means an individual or corporation, partnership, trust,
incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof)
or other entity of any kind.

                "PLACEMENT AGENTS" means collectively, Spencer Trask and R&R
individually.

                "PROCEEDING" means an action, claim, suit, investigation, or
proceeding (including, without limitation, an investigation or partial
proceeding, such as a deposition), whether commenced or threatened.

                "PROSPECTUS" means the prospectus included in the Registration
Statement (including, without limitation, a prospectus that includes any
information previously omitted from a prospectus filed as part of an effective
registration statement in reliance upon Rule 430A promulgated under the
Securities Act), as amended or supplemented by any Prospectus supplement, with
respect to the terms of the offering of any portion of the Registrable
Securities covered by the Registration Statement, and all other amendments and
supplements to the prospectus, including post-effective amendments, and all
material incorporated by reference or deemed to be incorporated by reference in
such Prospectus.

                "REGISTRABLE SECURITIES" means (i) the Shares, (ii) the Warrant
Shares, (iii) the shares of Common Stock issuable upon exercise of warrants
issued to Spencer Trask in connection with the Bridge Note financing (as
described in the Memorandum) (the "STV WARRANTS"), (iv) the shares of Common
Stock issuable upon exercise of the warrants issued to the Placement Agents or
their designees in connection the transactions contemplated by the Memorandum
and Merger Agreement (the "PLACEMENT AGENTS' WARRANTS"), (v) the shares of
Common Stock issuable upon the exercise of the Warrants to be issued to certain
officers of Pubco upon consummation of the Merger as contemplated by the Merger
Agreement (the "TM Management Warrants"), (vi) the shares of Common Stock issued
and issuable to B. Braun Medical, Inc. (the "Braun Shares") and (vii) together
with any shares of Common Stock issued or issuable upon any stock split,
dividend or other distribution, recapitalization or similar event

                                        2
<PAGE>

with respect to the foregoing or in connection with any anti-dilution provisions
in the Warrants, the STV Warrants, the Placement Agents' Warrants, the TM
Management Warrants and the Braun Shares.

                "REGISTRATION STATEMENT" means the registration statements
required to be filed hereunder, including (in each case) the Prospectus,
amendments and supplements to the registration statement or Prospectus,
including pre- and post-effective amendments, all exhibits thereto, and all
material incorporated by reference or deemed to be incorporated by reference in
the registration statement.

                "RULE 144" means Rule 144 promulgated by the Commission pursuant
to the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

                "RULE 415" means Rule 415 promulgated by the Commission pursuant
to the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

                "RULE 424" means Rule 424 promulgated by the Commission pursuant
to the Securities Act, as such Rule may be amended from time to time, or any
similar rule or regulation hereafter adopted by the Commission having
substantially the same effect as such Rule.

                "SECURITIES ACT" means the Securities Act of 1933, as amended.

                "SHARES" means the shares of Common Stock issued or issuable to
each Purchaser pursuant to the Merger Agreement.

                "TRADING DAY" means (i) a day on which the Common Stock is
traded on a Trading Market on which it is listed, or (ii) if the Common Stock is
not listed on a Trading Market, a day on which the Common Stock is traded on the
over-the-counter market, as reported by the OTC Bulletin Board, or (iii) if
trades of the Common Stock are not reported on the OTC Bulletin Board, a day on
which the Common Stock is quoted in the over-the-counter market as reported by
the National Quotation Bureau Incorporated (or any similar organization or
agency succeeding to its functions of reporting prices); provided, that in the
event that the Common Stock is not listed or quoted as set forth in (i), (ii)
and (iii) hereof, then Trading Day shall mean a Business Day.

                "TRADING MARKET" means the following markets or exchanges on
which the Common Stock is listed or quoted for trading on the date in question:
the American Stock Exchange, the New York Stock Exchange, the Nasdaq National
Market or the Nasdaq SmallCap Market.

                "WARRANTS" means the Common Stock Purchase Warrants issued or
issuable to the Purchasers pursuant to the terms of the Merger Agreement.

                                       3
<PAGE>

                "WARRANT SHARES" means the shares of Common Stock issuable upon
exercise of the Warrants.

        2.      REGISTRATION.

                (a)     Pubco shall prepare, and shall use it best efforts to
file with the Commission on or before the Filing Date, the Registration
Statement covering the resale of all of the Registrable Securities for an
offering to be made on a continuous basis pursuant to Rule 415. The Registration
Statement required hereunder shall, at Pubco's election, be on Form SB-2 (except
if Pubco is not then eligible to register for resale the Registrable Securities
on Form SB-2, in which case the Registration Statement shall be on another
appropriate form in accordance herewith) or Form S-1. The Registration Statement
required hereunder shall contain (except if otherwise directed by the Holders)
the "PLAN OF DISTRIBUTION" attached hereto as ANNEX A. Pubco shall use its best
efforts to cause the Registration Statement to become effective and remain
effective as provided herein. Pubco shall use its best efforts to cause the
Registration Statement to be declared effective under the Securities Act as
promptly as possible after the filing thereof, and shall use its best efforts to
keep the Registration Statement continuously effective under the Securities Act
until the earlier of (a) twenty-four months after the Effectiveness Date and (b)
such time when the Registrable Securities may be sold without volume
restrictions pursuant to Rule 144(k) as determined by the counsel to Pubco
pursuant to a written opinion letter to such effect, addressed and acceptable to
Pubco's transfer agent and the affected Holders (the "EFFECTIVENESS PERIOD").

                (b)     If: (i) a Registration Statement is not filed on or
prior to the Filing Date (if Pubco files a Registration Statement without
affording Holders the opportunity to review and comment on the same as required
by Section 3(a), Pubco shall not be deemed to have satisfied this clause (i));
or (ii) Pubco fails to file with the Commission a request for acceleration in
accordance with Rule 461 promulgated under the Securities Act, by the later of
(x) five Trading Days from the date that Pubco is notified (orally or in
writing, whichever is earlier) by the Commission that a Registration Statement
will not be "reviewed," or not subject to further review ("COMMISSION NOTICE")
and (y) ten Trading Days from the date that Pubco receives a Commission Notice
if (A) Pubco's Board of Directors determines in its good faith judgment that it
is advisable to delay the effectiveness of the Registration Statement, and (B)
Pubco provides each Holder with a certificate signed by the President or Chief
Executive Officer of the Company of such delay (not later than one day following
the receipt of notice from the Commission); or (iii) prior to the date when such
Registration Statement is first declared effective by the Commission, Pubco
fails to file a pre-effective amendment and otherwise respond in writing to
comments made by the Commission in respect of such Registration Statement within
ten Trading Days after the receipt of comments by or notice from the Commission
that such amendment is required in order for a Registration Statement to be
declared effective; or (iv) a Registration Statement filed or required to be
filed hereunder is not declared effective by the Commission on or before the
Effectiveness Date; or (v) after a Registration Statement is first declared
effective by the Commission, it ceases for any reason to remain continuously
effective as to all Registrable Securities for which it is required to be
effective, or the Holders are not permitted to utilize the Prospectus therein to
resell such Registrable Securities, for in any such cases twenty Trading Days
(which need not be

                                       4
<PAGE>

consecutive days) in the aggregate during any 12-month period (any such failure
or breach being referred to as an "EVENT," and for purposes of clause (i) or
(iv) the date on which such Event occurs, or for purposes of clause (ii) the
date on which such five or ten Trading Day period, as applicable, is exceeded,
or for purposes of clauses (iii) the date which such ten Trading Day period is
exceeded, or for purposes of clause (v) the date on which such twenty Trading
Day period is exceeded being referred to as "EVENT DATE"), then in addition to
any other rights the Holders may have hereunder or under applicable law: (x) on
each such Event Date, Pubco shall pay to each Purchaser an amount in cash, as
partial liquidated damages and not as a penalty, equal to 1% of the aggregate
purchase price paid by such Purchaser for the Registrable Securities then held
by such Purchaser and (y) on each monthly anniversary of each such Event Date
(if the applicable Event shall not have been cured by such date) until the
applicable Event is cured, Pubco shall pay to each Purchaser an amount in cash,
as partial liquidated damages and not as a penalty, equal to 2% of the aggregate
purchase price paid by such Purchaser for the Registrable Securities then held
by such Holder: PROVIDED, HOWEVER, that notwithstanding any provision herein to
the contrary, Pubco shall not be required to make payments under this Section
2(b) in excess of 10% of the aggregate purchase price paid by the Purchasers for
the Registrable Securities. If Pubco fails to pay any partial liquidated damages
pursuant to this Section 2(b) in full within seven days of the date payable,
Pubco shall pay interest thereon at a rate of 18% per annum (or such lesser
maximum amount that is permitted to be paid by applicable law) to the
Purchasers, accruing daily from the date such partial liquidated damages are due
until such amounts, plus all such interest thereon, are paid in full. The
liquidated damages pursuant to the terms hereof shall apply on a pro-rata basis
for any portion of a month prior to the cure of an Event.

                (c)     If during the Effectiveness Period, the number of
Registrable Securities at any time exceeds 100% of the number of shares of
Common Stock then registered in a Registration Statement, then Pubco shall file
as soon as practicable, an additional Registration Statement (or, if permitted
by law, a post-effective amendment to such Registration Statement) covering the
resale of Common Stock by the Holders of not less than all of such Registrable
Securities, and Pubco shall use best efforts to cause such Registration
Statement to be declared effective as soon as practicable thereafter.

        3.      REGISTRATION PROCEDURES.

                In connection with Pubco's registration obligations hereunder,
Pubco shall:

                (a)     Not less than three Trading Days prior to the filing of
the Registration Statement or any related Prospectus or any amendment or
supplement thereto, (i) furnish to the Holders copies of all such documents
proposed to be filed (including documents incorporated or deemed incorporated by
reference to the extent requested by such Person) which documents will be
subject to the review of such Holders, and (ii) cause its officers and
directors, counsel and independent certified public accountants to respond to
such inquiries as shall be necessary, in the reasonable opinion of Pubco's
counsel to conduct a reasonable investigation within the meaning of the
Securities Act. In the event a Holder fails to respond with three days of
receipt of the documents provided in accordance with (i) above, such Holder it
will be deemed to consent to the filing of the Registration Statement. Pubco
shall not file the Registration Statement or any

                                       5
<PAGE>

such Prospectus or any amendments or supplements thereto to which the Holders of
a majority of the Registrable Securities shall reasonably object in good faith
within such three day period unless and until Pubco shall have reasonably
responded to such objections.

                (b)     (i) Prepare and file with the Commission such
amendments, including post-effective amendments, to the Registration Statement
and the Prospectus used in connection therewith as may be necessary to keep the
Registration Statement continuously effective as to the applicable Registrable
Securities for the Effectiveness Period and prepare and file with the Commission
such additional Registration Statements in order to register for resale under
the Securities Act all of the Registrable Securities; (ii) cause the related
Prospectus to be amended or supplemented by any required Prospectus or
Prospectus supplement, and as so supplemented or amended to be filed pursuant to
Rule 424; (iii) when the Commission notifies Pubco if there will be a "review"
of the Registration Statement and whenever the Commission comments in writing on
the Registration Statement, respond as promptly as possible to any comments
received from the Commission with respect to the Registration Statement or any
amendment thereto and, as promptly as possible, and in any event within five
Trading Days provide the Placement Agents' counsel with true and complete copies
of all correspondence from and to the Commission relating to the Registration
Statement; and (iv) comply in all material respects with the provisions of the
Securities Act and the Exchange Act with respect to the disposition of all
Registrable Securities covered by the Registration Statement during the
applicable period in accordance with the intended methods of disposition by the
Holders thereof set forth in the Registration Statement as so amended or in such
Prospectus as so supplemented.

                (c)     Notify the Holders of Registrable Securities to be sold,
as promptly as reasonably possible (and, in the case of (i)(A) below, not less
than two Trading Days prior to such filing) and (if requested by any such
Person) confirm such notice in writing promptly following the day: (i)(A) when a
Prospectus or any Prospectus supplement or post-effective amendment to the
Registration Statement is proposed to be filed; (B) with respect to the
Registration Statement or any post-effective amendment, when the same has become
effective; (ii) of any request by the Commission or any other federal or state
governmental authority during the period of effectiveness of the Registration
Statement for amendments or supplements to the Registration Statement or
Prospectus or for additional information; (iii) of the issuance by the
Commission or any other federal or state governmental authority of any stop
order suspending the effectiveness of the Registration Statement covering any or
all of the Registrable Securities or the initiation of any Proceedings for that
purpose; (iv) of the receipt by Pubco of any notification with respect to the
suspension of the qualification or exemption from qualification of any of the
Registrable Securities for sale in any jurisdiction, or the initiation or threat
in writing of any Proceeding for such purpose; and (v) of the occurrence of any
event or passage of time that makes the financial statements included in the
Registration Statement ineligible for inclusion therein or any statement made in
the Registration Statement or Prospectus or any document incorporated or deemed
to be incorporated therein by reference untrue in any material respect or that
requires any revisions to the Registration Statement, Prospectus or other
documents so that, in the case of the Registration Statement or the Prospectus,
as the case may be, it will not contain any untrue statement of a material fact
or omit to state any material fact required to be stated therein or necessary to
make the statements therein, in light of the circumstances under which they were
made, not misleading.

                                       6
<PAGE>

                (d)     Use its best efforts to avoid the issuance of, or, if
issued, obtain the withdrawal of (i) any order suspending the effectiveness of
the Registration Statement, or (ii) any suspension of the qualification (or
exemption from qualification) of any of the Registrable Securities for sale in
any jurisdiction, at the earliest practicable moment.

                (e)     Furnish to each Holder, without charge, at least one
conformed copy of the Registration Statement and each amendment thereto,
including financial statements and schedules, all documents incorporated or
deemed to be incorporated therein by reference, to the extent requested, and all
exhibits, to the extent requested by such Person (including those previously
furnished or incorporated by reference), promptly after the filing of such
documents with the Commission.

                (f)     Promptly deliver to each Holder, without charge, as many
copies of the Prospectus or Prospectuses (including each form of prospectus) and
each amendment or supplement thereto as such Persons may reasonably request in
connection with resales by the Holder of Registrable Securities. Pubco hereby
consents to the use of such Prospectus and each amendment or supplement thereto
by each of the selling Holders in connection with the offering and sale of the
Registrable Securities covered by such Prospectus and any amendment or
supplement thereto, except after the giving on any notice pursuant to Section
3(c).

                (g)     Prior to any resale of Registrable Securities by a
Holder, use its best efforts to register or qualify or cooperate with the
selling Holders in connection with the Registration or qualification (or
exemption from the registration or qualification) of such Registrable Securities
for the resale by the Holder under the securities or Blue Sky laws of such
jurisdictions within the United States as any Holder reasonably requests in
writing, to keep each such Registration or qualification (or exemption
therefrom) effective during the Effectiveness Period and to do any and all other
acts or things reasonably necessary to enable the disposition in such
jurisdictions of the Registrable Securities covered by the Registration
Statement; PROVIDED, that Pubco shall not be required to qualify generally to do
business in any jurisdiction where it is not then so qualified, subject Pubco to
any material tax in any such jurisdiction where it is not then so subject or
file a general consent to service of process in any such jurisdiction.

                (h)     If requested by the Holders, cooperate with the Holders
to facilitate the timely preparation and delivery of certificates representing
Registrable Securities to be delivered to a transferee pursuant to the
Registration Statement, which certificates shall be free, to the extent
permitted by the Merger Agreement, of all restrictive legends, and to enable
such Registrable Securities to be in such denominations and registered in such
names as any such Holders may request.

                (i)     Upon the occurrence of any event contemplated by Section
3(c)(v), as promptly as reasonably possible, prepare a supplement or amendment,
including a post-effective amendment, to the Registration Statement or a
supplement or amendment to the related Prospectus or any document incorporated
or deemed to be incorporated therein by reference, and file any other required
document so that, as thereafter delivered, neither the Registration Statement
nor such Prospectus will contain an untrue statement of a material fact or omit
to state

                                       7
<PAGE>

a material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they were made,
not misleading. If Pubco notifies the Holders in. accordance with clauses (ii)
through (v) of Section 3(c) above to suspend the use of any Prospectus until the
requisite changes to such Prospectus have been made, then the Holders shall
suspend use of such Prospectus. Pubco will use its best efforts to ensure that
the use of the Prospectus may be resumed as promptly as is practicable. Pubco
shall be entitled to exercise its right under this Section 3(i) to suspend the
availability of a Registration Statement and Prospectus, subject to the payment
of liquidated damages pursuant to Section 2(b), for a period not to exceed 90
days (which need not be consecutive days) in any twelve month period.

                (j)     Comply with all applicable rules and regulations of the
Commission.

                (k)     Pubco may require each Holder to furnish to Pubco a
certified statement as to (i) the number of shares of Common Stock beneficially
owned by such Holder, (ii) if required by the Commission, the holder thereof or
the person that has voting and dispositive control over such Shares, (iii) any
relationship between such Holder and Pubco and (iv) such other information
regarding such Holder as shall be required by the Commission. If any such Holder
fails to furnish such information within three Trading Days of Pubco's request,
Pubco shall furnish written notice of such non-compliance to such Holder, the
applicable Placement Agent and the applicable Placement's Agent's counsel. If,
for a period of two Trading Days after such notice is given, such Holder
continues to fail to furnish such information, then (i) Pubco shall no longer be
obligated to register any of such Holder's Registrable Securities as part of the
Registration Statement: PROVIDED, HOWEVER, in the event such Holder provides
such information to Pubco prior to the time when Pubco files a request for
effectiveness, Pubco shall register such Holder's Registrable Securities as part
of the Registration Statement and (ii) Pubco shall have no obligation to pay any
liquidated damages to such Holder with respect to any Event. In the event that
(i) the immediately preceding sentence applies, (ii) thereafter such Holder
provides such information to Pubco and (iii) thereafter Pubco files another
registration statement in which Pubco may include such Holder's securities
without significant cost to Pubco and with the consent of any applicable
underwriter, then Pubco shall use its best efforts to include such Holder's
Registrable Securities in such registration statement in accordance with
customary arrangements applicable to piggyback registration rights.

        4.      REGISTRATION EXPENSES. All fees and expenses incident to the
performance of or compliance with this Agreement by Pubco shall be borne by
Pubco whether or not any Registrable Securities are sold pursuant to the
Registration Statement. The fees and expenses referred to in the foregoing
sentence shall include, without limitation, (i) all registration and filing fees
(including, without limitation, fees and expenses (A) with respect to filings
required to be made with the Trading Market on which the Common Stock is then
listed for trading, and (B) in compliance with applicable state securities or
Blue Sky laws), (ii) printing expenses (including, without limitation, expenses
of printing certificates for Registrable Securities and of printing prospectuses
if the printing of prospectuses is reasonably requested by the holders of a
majority of the Registrable Securities included in the Registration Statement)
in connection with the performance by Pubco of its obligations hereunder, (iii)
messenger, telephone and delivery expenses, (iv) fees and disbursements of
counsel for Pubco, (v) Securities Act liability insurance, if Pubco so desires
such insurance, and (vi) fees and expenses of all other Persons retained by

                                       8
<PAGE>

Pubco in connection with the consummation of the transactions contemplated by
this Agreement. In addition, Pubco shall be responsible for all of its internal
expenses incurred in connection with the consummation of the transactions
contemplated by this Agreement (including, without limitation, all salaries and
expenses of its officers and employees performing legal or accounting duties),
and the expense of any annual audit. Pubco shall not be responsible for any
Holder's brokerage commissions or other underwriting discount paid by any Holder
in connection with the sale of any Registrable Securities.

        5.      INDEMNIFICATION

                (a)     INDEMNIFICATION BY PUBCO. Pubco shall, notwithstanding
any termination of this Agreement, indemnify and hold harmless each Holder, the
officers, directors, agents and employees of each of them, each Person who
controls any such Holder (within the meaning of Section 15 of the Securities Act
or Section 20 of the Exchange Act) and the officers, directors, agents and
employees of each such controlling Person, to the fullest extent permitted by
applicable law, from and against any and all losses, claims, damages,
liabilities, costs (including, without limitation, reasonable attorneys' fees)
and expenses (collectively, "Losses"), as incurred, to the extent arising out of
or relating to any untrue or alleged untrue statement of a material fact
contained in the Registration Statement, any Prospectus or any form of
prospectus or in any amendment or supplement thereto or in any preliminary
prospectus, or arising out of or relating to any omission or alleged omission of
a material fact required to be stated therein or necessary to make the
statements therein (in the case of any Prospectus or form of prospectus or
supplement thereto, in light of the circumstances under which they were made)
not misleading, except to the extent, but only to the extent, that (1) such
untrue statements or omissions are based solely upon information regarding such
Holder furnished in writing to Pubco by such Holder expressly for use therein,
or to the extent that such information relates to such Holder or such Holder's
proposed method of distribution of Registrable Securities and was reviewed and
expressly approved in writing by such Holder expressly for use in the
Registration Statement, such Prospectus or such form of Prospectus or in any
amendment or supplement thereto (it being understood that each Holder has
approved ANNEX A hereto for this purpose) or (2) in the case of an occurrence of
an event of the type specified in Section 3(c)(ii)-(v), the use by such Holder
of an outdated or defective Prospectus after Pubco has notified such Holder in
writing that the Prospectus is outdated or defective and prior to the receipt by
such Holder of the Advice contemplated in Section 6(d). Pubco shall notify the
Holders promptly of the institution, threat or assertion of any Proceeding of
which Pubco is aware in connection with the transactions contemplated by this
Agreement.

                (b)     INDEMNIFICATION BY HOLDERS. Each Holder shall, severally
and not jointly, indemnify and hold harmless Pubco, its directors, officers,
agents and employees, each Person who controls Pubco (within the meaning of
Section 15 of the Securities Act and Section 20 of the Exchange Act), and the
directors, officers, agents or employees of such controlling Persons, to the
fullest extent permitted by applicable law, from and against all Losses, as
incurred, to the extent arising out of or based upon: (x) such Holder's failure
to comply with the prospectus delivery requirements of the Securities Act or (y)
any untrue or alleged untrue statement of a material fact contained in any
Registration Statement, any Prospectus, or any form of prospectus, or in any
amendment or supplement thereto or in any preliminary prospectus, or arising out
of or

                                       9
<PAGE>

relating to any omission or alleged omission of a material fact required to be
stated therein or necessary to make the statements therein not misleading (i) to
the extent, but only to the extent, that such untrue statement or omission is
contained in any information so furnished in writing by such Holder to Pubco
specifically for inclusion in the Registration Statement or such Prospectus or
(ii) to the extent that (1) such untrue statements or omissions are based solely
upon information regarding such Holder furnished in writing to Pubco by such
Holder expressly for use therein, or to the extent that such information relates
to such Holder or such Holder's proposed method of distribution of Registrable
Securities and was reviewed and expressly approved in writing by such Holder
expressly for use in the Registration Statement (it being understood that each
Holder has approved ANNEX A hereto for this purpose), such Prospectus or such
form of Prospectus or in any amendment or supplement thereto or (2) in the case
of an occurrence of an event of the type specified in Section 3(c)(ii)-(v), the
use by such Holder of an outdated or defective Prospectus after Pubco has
notified such Holder in writing that the Prospectus is outdated or defective and
prior to the receipt by such Holder of the Advice contemplated in Section 6(d).
In no event shall the liability of any selling Holder hereunder be greater in
amount than the dollar amount of the net proceeds received by such Holder upon
the sale of the Registrable Securities giving rise to such indemnification
obligation.

                (c)     CONDUCT OF INDEMNIFICATION PROCEEDINGS. If any
Proceeding shall be brought or asserted against any Person entitled to indemnity
hereunder (an "INDEMNIFIED PARTY"), such Indemnified Party shall promptly notify
the Person from whom indemnity is sought (the "INDEMNIFYING PARTY") in writing,
and the Indemnifying Party shall have the right to assume the defense thereof,
including the employment of counsel reasonably satisfactory to the Indemnified
Party and the payment of all fees and expenses incurred in connection with the
defense thereof; provided, that the failure of any Indemnified Party to give
such notice shall not relieve the Indemnifying Party of its obligations or
liabilities pursuant to this Agreement, except (and only) to the extent that it
shall be finally determined by a court of competent jurisdiction (which
determination is not subject to appeal or further review) that such failure
shall have prejudiced the Indemnifying Party.

                An Indemnified Party shall have the right to employ separate
counsel in any such Proceeding and to participate in the defense thereof, but
the fees and expenses of such counsel shall be at the expense of such
Indemnified Party or Parties unless: (i) the Indemnifying Party has agreed in
writing to pay such fees and expenses; (ii) the Indemnifying Party shall have
failed promptly to assume the defense of such Proceeding and to employ counsel
reasonably satisfactory to such Indemnified Party in any such Proceeding; or
(iii) the named parties to any such Proceeding (including any impleaded parties)
include both such Indemnified Party and the Indemnifying Party, and such
Indemnified Party shall have been advised by counsel that a conflict of interest
is likely to exist if the same counsel were to represent such Indemnified Party
and the Indemnifying Party (in which case, if such Indemnified Party notifies
the Indemnifying Party in writing that it elects to employ separate counsel at
the expense of the Indemnifying Party, the Indemnifying Party shall not have the
right to assume the defense thereof and the reasonable fees and expenses of one
separate counsel shall be at the expense of the Indemnifying Party). The
Indemnifying Party shall not be liable for any settlement of any such Proceeding
effected without its written consent, which consent shall not be unreasonably
withheld. No Indemnifying Party shall, without the prior written consent of the
Indemnified Party, effect any

                                       10
<PAGE>

settlement of any pending Proceeding in respect of which any Indemnified Party
is a party, unless such settlement includes an unconditional release of such
Indemnified Party from all liability on claims that are the subject matter of
such Proceeding.

                All reasonable fees and expenses of the Indemnified Party
(including reasonable fees and expenses to the extent incurred in connection
with investigating or preparing to defend such Proceeding in a manner not
inconsistent with this Section 5) shall be paid to the Indemnified Party, as
incurred, within ten Trading Days of written notice thereof to the Indemnifying
Party; PROVIDED, that the Indemnified Party shall promptly reimburse the
Indemnifying Party for that portion of such fees and expenses applicable to such
actions for which such Indemnified Party is not entitled to indemnification
hereunder, determined based upon the relative faults of the parties.

                (d)     CONTRIBUTION. If a claim for indemnification under
Section 5(a) or 5(b) is unavailable to an Indemnified Party (by reason of public
policy or otherwise), then each Indemnifying Party, in lieu of indemnifying such
Indemnified Party, shall contribute to the amount paid or payable by such
Indemnified Party as a result of such Losses, in such proportion as is
appropriate to reflect the relative fault of the Indemnifying Party and
Indemnified Party in connection with the actions, statements or omissions that
resulted in such Losses as well as any other relevant equitable considerations.
The relative fault of such Indemnifying Party and Indemnified Party shall be
determined by reference to, among other things, whether any action in question,
including any untrue or alleged untrue statement of a material fact or omission
or alleged omission of a material fact, has been taken or made by, or relates to
information supplied by, such Indemnifying Party or Indemnified Party, and the
parties' relative intent, knowledge, access to information and opportunity to
correct or prevent such action, statement or omission. The amount paid or
payable by a party as a result of any Losses shall be deemed to include, subject
to the limitations set forth in Section 5(c), any reasonable attorneys' or other
reasonable fees or expenses incurred by such party in connection with any
Proceeding to the extent such party would have been indemnified for such fees or
expenses if the indemnification provided for in this Section was available to
such party in accordance with its terms.

                The parties hereto agree that it would not be just and equitable
if contribution pursuant to this Section 5(d) were determined by pro rata
allocation or by any other method of allocation that does not take into account
the equitable considerations referred to in the immediately preceding paragraph.
Notwithstanding the provisions of this Section 5(d), no Holder shall be required
to contribute, in the aggregate, any amount in excess of the amount by which the
proceeds actually received by such Holder from the sale of the Registrable
Securities subject to the Proceeding exceeds the amount of any damages that such
Holder has otherwise been required to pay by reason of such untrue or alleged
untrue statement or omission or alleged omission, except in the case of fraud by
such Holder. The indemnity and contribution agreements contained in this Section
5 are in addition to any liability that the Indemnifying Parties may have to the
other Indemnified Parties.

                                       11
<PAGE>

        6.      MISCELLANEOUS

                (a)     REMEDIES. In the event of a breach by Pubco or by a
Holder, of any of their obligations under this Agreement, each Holder or Pubco,
as the case may be, in addition to being entitled to exercise all rights granted
by law and under this Agreement, including recovery of damages, will be entitled
to specific performance of its rights under this Agreement. Each of Pubco and
each Holder agrees that monetary damages would not provide adequate compensation
for any losses incurred by reason of a breach by it of any of the provisions of
this Agreement and hereby further agrees that, in the event of any action for
specific performance in respect of such breach, it shall waive the defense that
a remedy at law would be adequate.

                (b)     NO PIGGYBACK ON REGISTRATIONS. Neither Pubco nor any of
its security holders (other than the Holders in such capacity pursuant hereto)
may include securities of Pubco in the Registration Statement other than the
Registrable Securities, and Pubco shall not after the date hereof enter into any
agreement providing any rights to be included with the Registration Statement to
any of its security holders. Pubco shall not file any other registration
statement until after the Effective Date other than any Registration Statement
(i) that may be required to be filed in connection with the reincorporation of
Pubco as a Delaware corporation and (ii) covering the registration requirements
of Pubco described in the Memorandum, other than with respect to the Restricted
Securities..

                (c)     COMPLIANCE. Each Holder covenants and agrees that it
will comply with the prospectus delivery requirements of the Securities Act as
applicable to it in connection with sales of Registrable Securities pursuant to
the Registration Statement.

                (d)     DISCONTINUED DISPOSITION. Each Holder agrees by its
acquisition of such Registrable Securities that, upon receipt of a notice from
Pubco of the occurrence of any event of the kind described in Section 3(c), such
Holder will forthwith discontinue disposition of such Registrable Securities
under the Registration Statement until such Holder's receipt of the copies of
the supplemented Prospectus and/or amended Registration Statement or until it is
advised in writing (the "ADVICE") by Pubco that the use of the applicable
Prospectus may be resumed, and, in either case, has received copies of any
additional or supplemental filings that are incorporated or deemed to be
incorporated by reference in such Prospectus or Registration Statement. Pubco
may provide appropriate stop orders to enforce the provisions of this paragraph.
Pubco agrees and acknowledges that any period during which the Holder is
required to discontinue the disposition of the Registered Securities hereunder
shall be subject to the provisions of Section 2(b).

                (e)     PIGGYBACK REGISTRATIONS. If at any time during the
Effectiveness Period there is not an effective Registration Statement covering
all of the Registrable Securities and Pubco shall determine to prepare and file
with the Commission a registration statement relating to an offering for its own
account or the account of others under the Securities Act of any of its equity
securities, other than on Form S-4 or Form S-8 (each as promulgated under the
Securities Act) or their then equivalents relating to equity securities to be
issued solely in connection with any acquisition of any entity or business or
equity securities issuable in connection with the stock

                                       12
<PAGE>

option or other employee benefit plans, then Pubco shall send to each Holder a
written notice of such determination and, if within fifteen days after the date
of such notice, any such Holder shall so request in writing, Pubco shall include
in such registration statement all or any part of such Registrable Securities
such Holder requests to be registered, subject to customary underwriter cutbacks
applicable to all holders of registration rights.

                (f)     AMENDMENTS AND WAIVERS. The provisions of this
Agreement, including the provisions of this sentence, may not be amended,
modified or supplemented, and waivers or consents to departures from the
provisions hereof may not be given, unless the same shall be in writing and
signed by Pubco and a majority in interest of the Holders of the then
outstanding Registrable Securities.

                (g)     NOTICES. Any notice or other communication required or
permitted to be given hereunder shall be in writing and shall be mailed by
certified mail, return receipt requested, or delivered against receipt to the
party to whom it is to be given (i) if to Pubco, to Vyteris, Inc., 13-01 Pollitt
Drive, Fairlawn, New Jersey 07410, Attention: Vincent L. DeCaprio, Ph.D, Telefax
number (201) 796-6057, with a copy to Lowenstein Sandler P.C., 65 Livingston
Avenue, Roseland, New Jersey 07068, Attention: Peter H. Ehrenberg, Esq., Telefax
number (973) 597-2351or (ii) if to the Purchaser, at the address set forth in
Pubco's records (or, in either case, to such other address as the party shall
have furnished in writing in accordance with the provisions of this Section
6(g)). Any notice or other communication given by certified mail shall be deemed
given at the time of certification thereof, except for a notice changing a
party's address which shall be deemed given at the time of receipt thereof.

                (h)     SUCCESSORS AND ASSIGNS. This Agreement shall inure to
the benefit of and be binding upon the successors and assigns of each of the
parties and shall inure to the benefit of each Holder.

                (i)     EXECUTION AND COUNTERPARTS. This Agreement may be
executed in any number of counterparts, each of which when so executed shall be
deemed to be an original and, all of which taken together shall constitute one
and the same Agreement. In the event that any signature is delivered by
facsimile transmission, such signature shall create a valid binding obligation
of the party executing (or on whose behalf such signature is executed) the same
with the same force and effect as if such facsimile signature were the original
thereof.

                (j)     GOVERNING LAW. All questions concerning the
construction, validity, enforcement and interpretation of this Agreement shall
be governed by and construed and enforced in accordance with the internal laws
of the State of Delaware, without regard to the principles of conflicts of law
thereof. Each party agrees that all legal proceedings concerning the
interpretations, enforcement and defense of the transactions contemplated by
this Agreement (whether brought against a party hereto or its respective
affiliates, directors, officers, shareholders, employees or agents) shall be
commenced exclusively in the state and federal courts sitting in the City of New
York, New York. Each party hereto hereby irrevocably submits to the exclusive
jurisdiction of the state and federal courts sitting in the City of New York,
New York for the adjudication of any dispute hereunder or in connection herewith
or with any transaction contemplated hereby or discussed herein (including with
respect to the enforcement

                                       13
<PAGE>

of this Agreement), and hereby irrevocably waives, and agrees not to assert in
any suit, action or proceeding, any claim that it is not personally subject to
the jurisdiction of any such court. Each party hereto hereby irrevocably waives
personal service of process and consents to process being served in any such
suit, action or proceeding by delivering a copy thereof via overnight delivery
(with evidence of delivery) to such party at the address in effect for notices
to it under this Agreement and agrees that such service shall constitute good
and sufficient service of process and notice thereof. Nothing contained herein
shall be deemed to limit in any way any right to serve process in any manner
permitted by law. Each party hereto hereby irrevocably waives, to the fullest
extent permitted by applicable law, any and all right to trial by jury in any
legal proceeding arising out of or relating to this Agreement or the
transactions contemplated hereby. If either party shall commence an action or
proceeding to enforce any provisions of this Agreement, then the prevailing
party in such action or proceeding shall be reimbursed by the other party for
its attorneys fees and other costs and expenses incurred with the investigation,
preparation and prosecution of such action or proceeding.

                (k)     CUMULATIVE REMEDIES. The remedies provided herein are
cumulative and not exclusive of any remedies provided by law.

                (1)     SEVERABILITY. If any term, provision, covenant or
restriction of this Agreement is held by a court of competent jurisdiction to be
invalid, illegal, void or unenforceable, the remainder of the terms, provisions,
covenants and restrictions set forth herein shall remain in full force and
effect and shall in no way be affected, impaired or invalidated, and the parties
hereto shall use their commercially reasonable efforts to find and employ an
alternative means to achieve the same or substantially the same result as that
contemplated by such term, provision, covenant or restriction. It is hereby
stipulated and declared to be the intention of the parties that they would have
executed the remaining terms, provisions, covenants and restrictions without
including any of such that may be hereafter declared invalid, illegal, void or
unenforceable.

                (m)     HEADINGS. The headings in this Agreement are for
convenience of reference only and shall not limit or otherwise affect the
meaning hereof.

                (n)     INDEPENDENT NATURE OF PURCHASERS' OBLIGATIONS AND
RIGHTS. The obligations of each Purchaser hereunder is several and not joint
with the obligations of any other Purchaser hereunder, and no Purchaser shall be
responsible in any way for the performance of the obligations of any other
Purchaser hereunder. Nothing contained herein or in any other agreement or
document delivered at any closing, and no action taken by any Purchaser pursuant
hereto or thereto, shall be deemed to constitute the Purchasers as a
partnership, an association, a joint venture or any other kind of entity, or
create a presumption that the Purchasers are in any way acting in concert with
respect to such obligations or the transactions contemplated by this Agreement.
Each Purchaser shall be entitled to protect and enforce its rights, including
without limitation the rights arising out of this Agreement, and it shall not be
necessary for any other Purchaser to be joined as an additional party in any
proceeding for such purpose.

                                       14
<PAGE>

                (o)     FORM S-3 ELIGIBILITY. In the event that Pubco becomes
eligible to include the Registrable Securities on a registration statement on
Form S-3 and is able to do so in a manner which will not cause there to be any
lack of effective registration statement covering Registrable Securities, Pubco
shall be permitted to amend the exiting Registration Statement by a
post-effective amendment on Form S-3 (if permitted by the rules and regulations
of the Commission and under applicable law) or utilize a registration statement
on Form S-3 covering the Registrable Securities.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       15
<PAGE>

        IN WITNESS WHEREOF, the parties have executed this Registration Rights
Agreement as of the date first written above.

                            TREASURE MOUNTAIN HOLDINGS, INC.

                            By: /s/   Michael McGuinness
                                --------------------------------------------
                                Name:  Michael McGuinness
                                Title: CFO

                    [PURCHASER'S SIGNATURE PAGE TO PUBCO RRA]

                            PURCHASER

                            See Omnibus Signature Page for Purchaser's Signature

                                --------------------------------------------

                   [PLACEMENT AGENTS' SIGNATURE TO PUBCO RAA]

                            SPENCER TRASK VENTURES, INC.

                            By: /s/ William P. Dioguardi
                                --------------------------------------------
                                Name:  William P. Dioguardi
                                Title: President

                            RODMAN & RENSHAW, LLC

                            By: /s/ Thomas G. Pinou
                                --------------------------------------------
                                Name:  Thomas G. Pinou
                                Title: Chief Financial Officer

                      [TM MANAGEMENT SIGNATURES TO THE RRA]

                                /s/ Lane Clissold
                                --------------------------------------------
                                Name: Lane Clissold
                                /s/ George Norman
                                --------------------------------------------
                                George Norman

                                       16
<PAGE>

                         [B. BRAUN SIGNATURE TO THE RRA]

                                B. BRAUN MEDICAL, INC.

                                By:
                                   -----------------------------------------
                                   Name:
                                   Title:

                                       17
<PAGE>

                                     ANNEX A

                              PLAN OF DISTRIBUTION

        The Selling Stockholders (the "SELLING STOCKHOLDERS") and any of their
pledgees, donees, assignees and successors-in-interest may, from time to time,
sell any or all of their shares of Common Stock on any stock exchange, market or
trading facility on which the shares arc traded or in private transactions.
These sales may be at fixed or negotiated prices. The Selling Stockholders may
use any one or more of the following methods when selling shares:

        o       ordinary brokerage transactions and transactions in which the
                broker-dealer solicits purchasers;

        o       block trades in which the broker-dealer will attempt to sell the
                shares as agent but may position and resell a portion of the
                block as principal to facilitate the transaction;

        o       purchases by a broker-dealer as principal and resale by the
                broker-dealer for its account;

        o       an exchange distribution in accordance with the rules of the
                applicable exchange;

        o       privately negotiated transactions;

        o       settlement of short sales;

        o       broker-dealers may agree with the Selling Stockholders to sell a
                specified number of such shares at a stipulated price per share;

        o       a combination of any such methods of sale; and

        o       any other method permitted pursuant to applicable law.

        The Selling Stockholders may also sell shares under Rule 144, if
available, rather than under this Prospectus.

        Broker-dealers engaged by the Selling Stockholders may arrange for other
broker-dealers to participate in sales. Broker-dealers may receive commissions
or discounts from the Selling Stockholders (or, if any broker-dealer acts as
agent for the purchaser of shares, from the purchaser) in amounts to be
negotiated. The Selling Stockholders do not expect these commissions and
discounts relating to its sales of shares to exceed what is customary in the
types of transactions involved.

        The Selling Stockholders may from time to time pledge or grant a
security interest in some or all of the Common Stock owned by them and, if they
default in the performance of their secured obligations, the pledgees or secured
parties may offer and sell the shares of Common Stock from time to time under
this Prospectus, or under an amendment to this Prospectus under Rule 424(b)(3)
or other applicable provision of the Securities Act.

                                       18
<PAGE>

        The Selling Stockholders and any broker-dealers or agents that are
involved in selling the shares may be deemed to be "underwriters" within the
meaning of the Securities Act in connection with such sales. In such event, any
commissions received by such broker-dealers or agents and any profit on the
resale of the shares purchased by them may be deemed to be underwriting
commissions or discounts under the Securities Act. The Selling Stockholders have
informed Pubco that it does not have any agreement or understanding, directly or
indirectly, with any person to distribute the Common Stock.

        Pubco is required to pay all fees and expenses incurred by Pubco
incident to the registration of the shares. Pubco has agreed to indemnify the
Selling Stockholders against certain losses, claims, damages and liabilities,
including liabilities under the Securities Act.

                                       19<PAGE>

                                  EXHIBIT 10.9
                                  ------------

                         Securities Purchase Agreement

<PAGE>

                          SECURITIES PURCHASE AGREEMENT
                                   DATED AS OF
                               SEPTEMBER 28, 2004
                                 WITH RESPECT TO

                         11.5% SENIOR SECURED GRID NOTES

================================================================================

<PAGE>

                          SECURITIES PURCHASE AGREEMENT

        This SECURITIES PURCHASE AGREEMENT (this "Agreement") dated this 28th
day of September, 2004 (the "Effective Date") is entered into by and among
Spencer Trask Specialty Group, LLC ("Spencer Trask"), Vyteris, Inc., a Delaware
corporation (the "Company") and the individuals and entities listed on EXHIBIT A
hereto under the heading "Initial Purchasers" (the "Initial Purchasers") who
become parties to this Agreement by executing and delivering a financing
signature page in the form attached hereto as EXHIBIT B (the "Financing
Signature Page"), and the individuals and entities who become parties to this
Agreement after the date hereof in accordance with Section 2.2 hereof by
executing and delivering a Financing Signature Page (the "Additional
Purchasers"). Additional Purchasers may include the Initial Purchasers. The
Initial Purchasers and the Additional Purchasers are collectively referred to
herein as the "Purchasers."

        WHEREAS, the Company desires to sell to the Purchasers, and the
Purchasers desire to purchase from the Company, (a) one million shares (the
"Shares") of the Company's common stock, $0.0001 par value per share (the
"Common Stock"), (b) 11.5% Senior Secured Grid Notes (each, a "Note," and
collectively, the "Notes"), in substantially the form attached hereto as EXHIBIT
C and (c) warrants (each, a "Warrant," and collectively, the "Warrants"), in
substantially the form attached hereto as EXHIBIT D, pursuant to the terms of
this Agreement; and

        WHEREAS, each time a Purchaser loans funds to the Company, the Company
shall issue to the Purchaser a Warrant to purchase up to such number of shares
of Common Stock equal to the quotient obtained by dividing (i) 40% of the amount
funded pursuant to the terms of each Notes, by (ii) 1.50

        NOW, THEREFORE, in consideration of the mutual covenants and agreements
set forth in this Agreement, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties do hereby
agree as follows:

        1.      AUTHORIZATION; SALE OF SHARES, NOTES AND WARRANTS.

                1.1     AUTHORIZATION. The Company has, or before the Closings
(as defined in Section 2.2) will have, duly authorized the sale and issuance,
pursuant to the terms of this Agreement, of the Shares, the Notes, the Warrants,
the issuance of the Common Stock issuable upon exercise of the Warrants (the
"Warrant Shares").

                1.2     SALE OF NOTES AND WARRANTS. Subject to the terms and
conditions of this Agreement, at the Closing, the Company will sell and each of
the Purchasers will purchase severally and not jointly the Shares, Notes in the
principal amounts set forth on EXHIBIT A attached hereto and Warrants. The terms
and provisions of the Notes and Warrants are more fully set forth in the forms
of Note and Warrant, true and correct copies of each are attached hereto as
EXHIBITS C and D, respectively.

                1.3     SALE OF THE SHARES. As a material inducement for the
Purchasers entering into this Agreement, and for other good and valuable
consideration, receipt and adequacy of which is acknowledged by the Company, the
Company shall issue the Shares to Spencer Trask Specialty Group, LLC ("STSG") on
the date hereof in the denomination set forth in EXHIBIT A hereto.

                                      -2-
<PAGE>

        2.      PURCHASE PRICE; CLOSING.

                2.1     PURCHASE PRICE. The aggregate principal amount of the
Notes is limited to the lesser of $5,000,000 and the Available Loan Amount (as
defined in the Note); and

                2.2     THE INITIAL CLOSING. Subject to the terms and conditions
of this Agreement, the initial closing (the "Initial Closing") of the sale and
purchase of Shares, Notes and Warrants under this Agreement shall take place at
the offices of Littman Krooks LLP, 655 Third Avenue, New York, New York 10017
(or remotely via the exchange of documents and signatures) on the Effective Date
(the "Initial Closing Date"). At the Initial Closing, (i) the Company shall
deliver to each of the Initial Purchasers: (A) the Notes in the aggregate
principal amount set forth opposite such Initial Purchaser's name on EXHIBIT A
attached hereto and (B) the Warrants to purchase an amount of shares Common
Stock as set forth opposite such Initial Purchaser's name on EXHIBIT A attached
thereto; (ii) the Company and STSG, as agent for the Initial Purchasers, shall
execute and deliver the Security Agreement in the form attached hereto as
EXHIBIT E (the "Security Agreement"); (iii) the Company and STSG shall execute
and deliver the Warrant Agreement attached hereto as EXHIBIT Fand (iv) each
Initial Purchaser shall pay directly to the Company, by wire transfer of
immediately available funds, a portion of the Purchase Price equal to the
aggregate principal amount of the Note so purchased.

                2.3     ADDITIONAL CLOSINGS. Additional sales of Notes and
Warrants not sold at the Initial Closing may be made by the Company to the
Additional Purchasers, if any, at one or more closings (each, an "Additional
Closing"), until October 1, 2005, unless extended upon agreement of the Company
and the Purchasers. Each Additional Closing and the Initial Closing are
collectively referred to as the "Closings" and the date of each Additional
Closing and the Initial Closing are collectively referred to as the "Closing
Dates." At each Additional Closing, (i) each Additional Purchaser purchasing
Notes and Warrants at such Additional Closing shall execute and deliver a
Financing Signature Page, and upon acceptance by the Company of such Financing
Signature Page, such Additional Purchaser shall become a "Purchaser" hereunder,
(ii) the Company shall issue and deliver to each Additional Purchaser who
purchases a Note and Warrant at such Additional Closing certificates
representing the principal amount of the Notes and Warrants being purchased and
at such Additional Closing by such Additional Purchaser against payment to the
Company of an amount equal to the principal amount for the Note being purchased
by such Additional Purchaser, and (iii) the Company shall cause EXHIBIT A hereto
to be amended to include each Additional Purchaser and all corresponding
information specified in each such Exhibit (the "Revised Exhibit"). The Purchase
Price shall be paid directly to the Company, by wire transfer of immediately
available funds. The Company shall deliver the Revised Exhibit to each
Purchaser, within a reasonable time period following each Additional Closing.

                2.4     DUTY TO PROVIDE LOANS. In consideration of receipt of
the Shares, from the date hereof until October 1, 2005, Spencer Trask hereby
agrees to loan to the Company (either directly or through one or more related
parties) up to the lessor of $5,000,000 and the Available Loan Amount (as
defined in the Note), at such time or times as the Company, in its sole and
absolute discretion, shall request. The parties hereby agree and acknowledge
that such loan or loans shall be subject to the terms and conditions of this
Agreement and the attached Notes.

        3.      REPRESENTATIONS OF THE COMPANY. To induce the Purchasers to
enter into this Agreement and to purchase the Notes hereunder, the Company
hereby warrants, represents and covenants to the Purchasers as set forth below
in this Section 3. Except as set forth on the Disclosure Schedule attached to
this Agreement as SCHEDULE 1, (the "Disclosure Schedule", such Disclosure
Schedule being arranged in sections corresponding to the sections contained in
this Section 3), the Company represents and warrants to the Purchasers that as
of the Closing Date:

                3.1     DUE ORGANIZATION AND QUALIFICATION. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware. The Company has all requisite power and authority to
own, lease and operate its assets and properties and to carry on its business as
presently conducted and as presently contemplated. The Company is duly qualified
to transact business and is in good standing in each jurisdiction in which the
nature of its business or the locations of its property requires such
qualification, except where the failure to do so would not have a material
adverse effect on the Company's business, operations, assets or condition
(financial or otherwise).

                3.2     POWER AND AUTHORITY. The Company has the requisite
corporate power and authority to execute and deliver this Agreement and the
Shares, Notes and Warrants and to perform its obligations hereunder and

                                      -3-
<PAGE>

thereunder. The execution, delivery and performance of this Agreement have been
duly authorized by all necessary corporate action on the part of Company. This
Agreement has been duly executed and delivered by the Company and is the valid
and binding obligation of the Company, enforceable against the Company in
accordance with its terms, except as such enforceability may be limited by
applicable bankruptcy, moratorium, insolvency, reorganization or other similar
laws now or hereafter in effect generally affecting the enforcement of
creditors' rights, specific performance, injunctive or other equitable remedies.
When executed and delivered by the Company at the Closing, each Note and Warrant
will be the valid and binding obligation of the Company, enforceable against the
Company in accordance with its terms, except as such enforceability may be
limited by bankruptcy, moratorium, insolvency, reorganization or other similar
laws now or hereafter in effect generally affecting the enforcement of
creditors' rights, specific performance, injunctive or other equitable remedies.

                3.3     RESERVATION OF SHARES. The Company shall use its best
efforts, including soliciting its stockholders for requisite approval, to at all
times have authorized and reserved for issuance a sufficient number of shares of
Common Stock to provide for the exercise of the Warrants. The Company agrees
that the issuance of the Warrants shall constitute full authority to its
officers who are charged with the duty of executing stock certificates to
execute and issue the necessary certificates for the Warrants Shares issuable
upon exercise of the Warrants or any securities issued in connection with the
Warrant.

                3.4     CAPITALIZATION; SUBSIDIARIES. The authorized capital
stock of the Company consists solely of 100,000,000 shares of common stock,
$.0001 par value per share (the "Common Stock"), and 50,000,000 shares of
preferred stock, par value $.0001 per share ("Preferred Stock"), of which
333,333 shares are designated Series A Convertible Preferred Stock ("Series A
Stock"), and 7,500,000 shares are designated Series C Convertible Preferred
Stock ("Series C Stock"). There are as of the date hereof, and will be, as of
the Closing Date, 24,865,888 (excluding the 1,000,000 shares to be issued in
exchange for STSG's commitment to provide the Working Capital Facility and
including 15,908 shares issued as a result the exercise of stock options by
employees during the month of September 2004) (as described on the DISCLOSURE
SCHEDULE)shares of Common Stock issued and outstanding; and 75,134,112 shares of
Common Stock reserved for issuance consisting of:

                o       6,925,779 shares of Common Stock reserved for issuance
                        pursuant to the Company's stock option plan, a true and
                        complete list of which options and grants is set forth
                        in the DISCLOSURE SCHEDULE,
                o       6,848,000 shares of Common Stock reserved for issuance
                        pursuant to the warrants, a true and complete list of
                        which is set forth in the DISCLOSURE SCHEDULE,
                o       92,593 shares of Common Stock reserved for issuance
                        pursuant to the license, development and distribution
                        agreement dated September 20, 2002 by and between the
                        Company and B. Braun Medical Inc.,
                o       83,333 shares of Common Stock reserved for issuance upon
                        conversion of the 333,333 shares of Series A Stock
                        issued and outstanding,
                o       1,875,000 shares of Common Stock reserved for issuance
                        upon the conversion of the 7,500,000 shares of Series
                        C Stock issued and outstanding, and
                o       8,622,500 shares of Common Stock reserved for issuance
                        upon the conversion of certain convertible notes, a true
                        and complete list of which is set forth in the
                        DISCLOSURE Schedule.

The Preferred Stock issued and outstanding as of each such date shall consist
solely of 333,333 shares of Series A Stock held by the Series A shareholder,
Becton Dickinson and Company, and 7,500,000 shares of Series C Stock held by the
sole Series C shareholders, Spencer Trask Specialty Group, LLC and Donald F.
Farley. All of the issued and outstanding shares of capital stock of the Company
have been duly authorized, and are validly issued, fully paid and
non-assessable.

                3.5     OPTIONS; SHAREHOLDER RIGHTS. Except as set forth on the
DISCLOSURE SCHEDULE, there are no outstanding obligations, options, warrants,
convertible notes or other securities, subscriptions, or other commitments or
rights (matured or contingent) of any nature to acquire or subscribe for any
securities or other equity interest of or in the Company. The DISCLOSURE
SCHEDULE also sets forth the exercise price and expiration dates of all
outstanding options and warrants to acquire securities of the Company. Except as
set forth in the DISCLOSURE SCHEDULE, there are no bonds, debentures, notes or
other indebtedness of the Company having the right to vote (or convertible into,

                                      -4-
<PAGE>

or exchangeable for, securities having the right to vote) on any matter on which
any stockholder of the Company may vote. Except as set forth on the DISCLOSURE
SCHEDULE, there are no preemptive rights, rights of first refusal, voting
agreements, anti-dilution or "ratchet" protections or other rights that any
stockholder of the Company would be entitled to exercise or invoke as a result
of the purchase by a Purchaser of a Note in accordance with the terms of this
Agreement.

                3.6     AUTHORIZATION OF THE SHARES, NOTES AND WARRANTS. All
corporate action on the part of the Company necessary for the authorization,
issuance, sale and/or delivery of the Shares, Notes and Warrants has been taken.

                3.7     COMPLIANCE WITH LAWS. The Company is in compliance in
all material respects with all Federal, state, local and foreign laws, statutes,
ordinances, regulations, orders, judgments, injunctions, awards or decrees
(collectively, "Laws") applicable to it or any of its material properties or
operations. The Company has not received any notice of material violation or
alleged material violation of any Law by it. The Company has all material
licenses, permits, orders and approvals of Federal, state, local and foreign
governmental or regulatory bodies necessary for the conduct of its business and
operations as presently conducted.

                3.8     NO BREACH; CONSENTS. Except as set forth on the
DISCLOSURE SCHEDULE, the execution, delivery and performance of this Agreement
and the Notes by the Company and the consummation by the Company of the
transactions contemplated hereby will not (i) result in any lien, pledge,
mortgage, security interest, claim, lease, charge, option, easement, servitude
or other encumbrance whatsoever (collectively, "Liens") upon any of the property
of the Company (other than in favor of the Purchasers) or (ii) violate, conflict
with or breach any of the terms and conditions of, result in a material
modification of, accelerate or trigger the rights of any person under, or
constitute (or with notice or lapse of time or both would constitute) a default
under (a) any material instrument, contract or other agreement to which the
Company is a party or by or to which it or any of its properties is bound or
subject; (b) the Company's Certificate of Incorporation or By-laws (and all
amendments thereto up through the date hereof); or (c) any Law applicable to the
Company or any of its properties or operations. Except as set forth on the
DISCLOSURE SCHEDULE, no consent, approval or authorization of, or declaration or
filing with, any governmental authority, stockholder of the Company or other
person is required on the part of the Company in connection with the execution,
delivery or performance of this Agreement or the consummation by it of the
transactions contemplated hereby.

                3.9     LITIGATION. Except as set forth on the DISCLOSURE
SCHEDULE, there are no material suits or actions, administrative, arbitration or
other proceedings or governmental investigations pending or, to the Company's
knowledge, threatened against or affecting the Company or any of its properties
or assets. There are no judgments, orders, injunctions, decrees or awards
against the Company that are not satisfied or remain outstanding.

                3.10    BROKERS. Except as set forth on the DISCLOSURE SCHEDULE,
neither the Company nor any of Company's officers, directors, employees or
stockholders has employed any broker or finder in connection with the
transactions contemplated by this Agreement and no fee is or will be due and
owing to any broker or finder in connection with the transactions contemplated
by this Agreement.

                3.11    INTELLECTUAL PROPERTY. Except as set forth on the
DISCLOSURE SCHEDULE, there is not pending nor, to Company's knowledge,
threatened any claim, suit or action contesting or challenging the rights of the
Company in or to any of the material item of intellectual property owned or used
by the Company in the conduct of its business (the "Intellectual Property") or
the validity of any of the Intellectual Property. To the Company's knowledge,
there is no infringement upon or unauthorized use of any of the Intellectual
Property by any third party. No officer, director, equity holder or affiliate of
the Company nor any of their respective associates has any right to or interest
in any of the Intellectual Property, including, without limitation, any right to
payments (by royalty or otherwise) in respect of any use or transfer thereof.

        4.      REPRESENTATIONS OF THE PURCHASERS. Each of the Purchasers
severally represents and warrants to the Company as follows:

                4.1     POST-CLOSING CURES AND REQUIREMENTS. The Purchaser
hereby represents that it agrees and acknowledges that (i) pursuant to the
Merger (as defined in that certain Confidential Private Placement Memorandum,
dated June 18, 2004), the Company will become a wholly-owned subsidiary of
Treasure Mountain

                                      -5-
<PAGE>

Holdings, Inc. ("Pubco"); (ii) at present, Pubco has an insufficient number and
type of shares of capital stock authorized to provide all of the merger
consideration contemplated by the proposed terms of the Merger; and (iii) after
consummation of the Merger, it is intended that the lack of authorized shares
will be cured either by (A) Pubco reincorporating in the State of Delaware by
merging into a subsidiary corporation that will have sufficient authorized
shares to provide all of the applicable merger consideration (the
"Reincorporation Merger"); or (B) amending the Pubco Certificate of
Incorporation to provide for additional authorized shares. The Purchaser hereby
agrees that, at any meeting (whether annual or special and whether or not an
adjourned or postponed meeting) of the holders of common stock of Pubco ("Pubco
Common Stock"), however called, or in connection with any written consent of the
holders of Pubco Common Stock, the Purchaser will appear at the meeting to, or
will otherwise cause the Purchaser's shares of Pubco Common Stock and any other
interests that the Purchaser may have in Pubco to be counted as present thereat
for purposes of establishing a quorum and will vote all of such Pubco capital
stock and any other interests in favor of, or will consent (with respect to such
capital stock and interests) to, the Reincorporation Merger, or, if proposed by
the Board of Directors of Pubco, will vote all of such Pubco capital stock and
any other interests in favor of, or will consent (with respect to such capital
stock and interests) to, an amendment to the Certificate of Incorporation of
Pubco to provide for the authorization of the shares required to be issued or
reserved for issuance pursuant to the Merger.

                4.2     EXISTENCE AND POWER. The Purchaser (a) is duly organized
and validly existing and (b) has the requisite power and authority to execute,
deliver and perform its obligations under this Agreement. In the event the
Purchaser is an individual, such Purchaser has the legal capacity to execute,
deliver and perform the obligations under this Agreement.

                4.3     AUTHORIZATION; NO CONTRAVENTION. The execution delivery
and performance by each Purchaser of this Agreement and the transactions
contemplated hereby, (a) have been duly authorized by all necessary action, (b)
do not contravene the terms of such Purchaser's organizational documents, or any
amendment thereof, and (c) do not violate, conflict with or result in any breach
or contravention of, or the creation of any lien under, any material contractual
obligation of such Purchaser or any requirement of law applicable to such
Purchaser, and (d) do not violate any orders of any court, arbitrational
tribunal, administrative agency or commission or other governmental or
regulatory authority or agency (each of the foregoing is hereafter referred to
as a "Governmental Entity") against, or binding upon, such Purchaser.

                4.4     GOVERNMENTAL AUTHORIZATION; THIRD PARTY CONSENTS. No
approval, consent, compliance, exemption, authorization or other action by, or
notice to, or filing with, any Governmental Entity or any other person, and no
lapse of a waiting period under any requirement of law, is necessary or required
in connection with the execution, delivery or performance (including, without
limitation, the purchase of the Notes) by, or enforcement against, the Purchaser
of this Agreement or the transactions contemplated hereby.

                4.5     BINDING EFFECT. This Agreement has been duly executed
and delivered by each Purchaser and constitutes the legal, valid and binding
obligations of such Purchaser, enforceable against it in accordance with its
terms, except as enforceability may be limited by applicable bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting generally the
enforcement of creditors' rights and subject to a court's discretionary
authority with respect to granting a decree ordering specific performance or
other equitable remedies.

                4.6     PURCHASE FOR OWN ACCOUNT. The Shares, Notes and Warrants
hereby acquired by each Purchaser pursuant to this Agreement are being acquired
for such Purchaser's own account and with no intention of distributing or
reselling such securities or the securities issuable upon exercise of the
Warrants in any transaction that would be in violation of the securities laws of
the United States of America or any state, without prejudice. If such Purchaser
should in the future decide to dispose of any of such Notes or Warrant or the
securities issuable upon exercise thereof, such Purchaser understands and agrees
that it may do so only in compliance with the Securities Act and applicable
state securities laws, as then in effect. Each Purchaser agrees to the
imprinting, so long as required by law, of legends on certificates representing
all of its Shares, Notes, Warrants, and Warrant Shares (hereinafter collectively
referred to as the "Securities").

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR THE SECURITIES LAWS OF
ANY STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE

                                      -6-
<PAGE>

REGISTRATION STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES LAWS OR
PURSUANT TO AN APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF SUCH
ACT AND SUCH LAWS.

                4.7     RESTRICTED SECURITIES. Each Purchaser understands that
none of the Securities will be registered at the time of their issuance under
the Securities Act since they are being acquired from the Company in a
transaction exempt from the registration requirements of the Securities Act and
that the reliance of the Company on such exemption is predicated in part on the
Purchaser's representations set forth herein.

                4.8     INVESTMENT REPRESENTATIONS. Each Purchaser is acquiring
the Securities, for such Purchaser's own account, for investment and not with a
view to, or for sale in connection with, any distribution of such securities or
any part thereof. Each Purchaser (i) has such knowledge and experience in
financial and business affairs that it is capable of evaluating the merits and
risks involved in purchasing the Securities, (ii) is able to bear the economic
risks involving in purchasing the Securities, (iii) is an "accredited investor"
as defined in Rule 501(a) of Regulation D promulgated under the Securities Act
and (iv) has had the opportunity to ask questions of, and receive answers from,
Company and persons acting on Company's behalf concerning Company's business,
management, and financial affairs and the terms and conditions of the
Securities. Each Purchaser's principal place of business is New York.

        5.      CONDITIONS OF CLOSING OF THE INITIAL PURCHASERS AND ADDITIONAL
PURCHASERS. The obligations of the Purchasers to purchase their respective Notes
and Warrants and transfer the Purchase Price for the Notes and Warrants being
purchased at the applicable Closing, as the case may be, are subject to the
fulfillment at or before such Closing, as applicable, of the following
conditions precedent, any one or more of which may be waived in whole or in part
by the Purchasers, which waiver shall be at the sole discretion of such
Purchasers:

                5.1     REPRESENTATIONS AND WARRANTIES. The representations and
warranties made by the Company in this Agreement shall have been true and
correct in all respects as of the date when made and as of each Closing Date,
except for the representations and warranties that are expressly made as of a
particular date (which shall remain true and correct as of such date).

                5.2     ISSUANCE OF SHARES. The Company shall have previously
issued 1,000,000 shares of Common Stock to STSGas consideration for entering
into this Agreement.

                5.3     AGREEMENTS. All agreements, and conditions contained in
this Agreement to be performed or complied with by the Company prior to the
Initial Closing or Additional Closing, as the case may be, shall have been
performed or complied with by the Company prior to or at the Initial or
Additional Closing, as applicable.

                5.4     CONSENTS, ETC. The Company shall have secured and
delivered to the Purchasers all consents and authorizations that shall be
necessary or required lawfully to consummate this Agreement and to issue the
Notes to be purchased by each Purchaser at the Initial or Additional Closing.

                5.5     DELIVERY OF DOCUMENTS. All of the documents to be
delivered by the Company pursuant to Sections 2.1 or 2.2, as applicable, shall
be in a form and substance reasonably satisfactory to the Purchasers and their
counsel, and shall have been executed and delivered to the Purchasers by each of
the other parties thereto.

                5.6     PROCEEDINGS AND DOCUMENTS. All corporate and other
proceedings in connection with the transactions contemplated by this Agreement
and all documents and instruments incident to such transactions shall be in a
form and substance reasonably satisfactory to the Purchasers and their counsel,
and the Purchasers and their counsel shall have received all such counterpart
originals or certified or other copies of such documents as the Purchasers or
their counsel may reasonably request.

        6.      CONDITIONS OF CLOSING OF THE COMPANY. The Company's obligations
to sell and issue the Notes at the Initial Closing or Additional Closings, as
the case may be, are subject to the fulfillment at or before the Initial Closing
or Additional Closings of the following conditions, which conditions may be
waived in whole or in part by the Company, and which waiver shall be at the sole
discretion of the Company:

                                      -7-
<PAGE>

                6.1     REPRESENTATIONS AND WARRANTIES. The representations and
warranties made by the Purchasers in this Agreement shall have been true and
correct in all respects as of the date when made and as of each Closing Date,
except for the representations and warranties that are expressly made as of a
particular date (which shall remain true and correct as of such date).

                6.2     AGREEMENTS. All agreements, and conditions contained in
this Agreement to be performed or complied with by the Purchasers prior to the
Initial Closing or Additional Closing, as the case may be, shall have been
performed or complied with by the Company prior to or at the Initial or
Additional Closing, as applicable.

                6.3     PAYMENT OF PURCHASE PRICE. The Purchasers shall have
tendered the aggregate Purchase Price in exchange for the Notes being issued
hereunder in accordance with Section 2.1 or 2.2, as applicable.

                6.4     DELIVERY OF DOCUMENTS. All of the documents to be
delivered by the Purchasers pursuant to Section 2.1 or 2.2, as applicable, shall
be in a form and substance reasonably satisfactory to the Company and its
counsel, and shall have been executed and delivered to the Company by each of
the other parties thereto.

        7       INTERCREDITOR AGREEMENT. Each Purchaser hereby agrees as
follows:

                7.1     STSG is hereby appointed by the Purchaser to act as
security agent (the "Security Agent") under the Security Agreement with respect
to the Collateral (as defined in the Security Agreement) and to take all actions
as contemplated in such capacity in the Security Agreement.

                7.2     At all times, whether before, after or during the
pendency of any bankruptcy, reorganization or other insolvency proceeding
involving the Company, notwithstanding the preferences or priorities resulting
from the order of granting or perfection of any liens, the order of filing or
recording of any financing statements or mortgages or the priorities that would
otherwise apply under applicable law:

                        (a)     The right to receive payments on the Notes and
the security interests of each Purchaser in all Collateral shall rank equally
and the Purchasers shall share therein and in the proceeds thereof PRO RATA
according to the unpaid principal and accrued interest due and owing to each
Purchaser from time to time under the Notes. No Purchaser shall challenge the
validity, perfection or priority of any Purchaser's security interest in the
Collateral pursuant to the Notes or challenge the relative priority thereof
established pursuant to this Agreement; and

                        (b)     Except as otherwise provided specifically
herein, priority shall be determined in accordance with applicable law. The
provisions of this Section 7.2(b) are, and are intended, solely for the purpose
of defining the relative rights of the Purchasers, and are solely for the
benefit of the Purchasers, and may not be relied upon or enforced by any party
other than then Purchasers, and nothing in this Section 7.2(b) is intended to or
shall impair the obligations of the Company.

                        (c)     Notwithstanding any contrary provision of the
Notes, a Note shall not be declared to be due and payable prior to the date on
which the Requisite Holders (as hereafter defined) declare same to be due and
payable.

                        (d)     A Purchaser shall not, without the prior written
consent of the Requisite Holders, institute proceedings to enforce any provision
of a Note, the Security Agreement, or this Agreement, notwithstanding any
provision to the contrary contained in the Notes, the Security Agreement or this
Agreement or in any agreement or instrument relating hereto or thereto.

                        (e)     The Security Agent upon the approval of the
Requisite Holders shall have the sole authority to decide upon the exercise of
any rights and remedies with respect to the Collateral (as defined in the
Security Agreement) under the Security Agreement for the benefit of all
Purchasers. No Purchaser shall have the right to take any action with respect to
the Collateral whether by judicial or non-judicial foreclosure, notification to
the Company's account debtors, or otherwise, except in accordance with the
preceding sentence.

                        (f)     In the event any payment or distribution of
assets of the Company of any kind or character, whether in cash, property or
securities, and whether or not pursuant to any dissolution, winding up,

                                      -8-
<PAGE>

liquidation or reorganization, not permitted by or in accordance with the
provisions of this Agreement or the Notes shall be received by a Purchaser, such
payment or distribution to such Purchaser shall not be commingled with other
funds and shall be held in trust for the benefit of, and shall be paid over or
delivered to, the party or parties entitled to receive such payment or
distribution, in the form received (except for the endorsement or assignment of
a Purchaser where necessary). In the event of any failure by a Purchaser to make
any such endorsement or assignment, the party or parties entitled to receive
such payment or distribution are hereby irrevocably authorized to make same.

                        (g)     The Security Agent shall only be obligated to
take action and shall act as directed by the Requisite Holders; neither the
Security Agent, nor any of its officers, directors, employees or affiliates
shall be responsible to Lenders for any losses that any of such Lenders may
incur hereunder or under the Security Agreement. The Security Agent shall be
entitled to conclusively rely on any such direction or consent from the
Requisite Holders. In addition, the Security Agent may act in reliance upon any
signature believed by it to be genuine, and may assume that any person who has
been designated by the Purchasers to give any written instructions, notice or
receipt, or make any statements in connection with the provisions hereof has
been duly authorized to do so. Security Agent shall have no duty to make inquiry
as to the genuineness, accuracy or validity of any statements or instructions or
any signatures on statements or instructions.

                        (h)     The Security Agent may resign at any time by
giving written notice ("Notice") to the Company and the Lenders, which
resignation shall be effective 30 days from the date of the Notice ("Effective
Resignation Date"). Upon the earlier of (i) the Effective Resignation Date or
(ii) the appointment of a successor Security Agent by the Requisite Holders, the
Security Agent shall have no further obligations hereunder. In the event a
successor Security Agent is not appointed by the Requisite Holders on or before
the Effective Resignation Date, then Security Agent shall have the right to
deliver any Collateral held by it with a clerk of a court of competent
jurisdiction or a third party escrow provider pending the appointment of a
successor Security Agent by the Requisite Holders.

        8       MISCELLANEOUS.

                8.1     SUCCESSORS AND ASSIGNS. This Agreement, and the rights
and obligations of each Purchaser hereunder, may be assigned by such Purchaser
to (a) any person or entity to which the Notes are transferred by such
Purchaser, or (b) to any Affiliated Party (as hereinafter defined), and, in each
case, such transferee shall be deemed a "Purchaser" for purposes of this
Agreement; provided that such assignment of rights shall be contingent upon the
transferee providing a written instrument to the Company notifying the Company
of such transfer and assignment and agreeing in writing to be bound by the terms
of this Agreement. The Company may not assign its rights under this Agreement.
For purposes of this Agreement, "Affiliated Party" shall mean, with respect to
any Purchaser, any person or entity which, directly or indirectly, controls, is
controlled by or is under common control with such Purchaser, including, without
limitation, any general partner, officer or director of such Purchaser and any
venture capital fund now or hereafter existing which is controlled by one or
more general partners of, or shares the same management company as, such
Purchaser.

                8.2     EXPENSES. Each party hereto shall pay its own expenses
relating to the transactions contemplated by this Agreement, including, without
limitation, the fees and expenses of their respective counsel, financial
advisors and accountants.

                8.3     SEVERABILITY. The invalidity or unenforceability of any
provision of this Agreement shall not affect the validity or enforceability of
any other provision of this Agreement.

                8.4     SPECIFIC PERFORMANCE. In addition to any and all other
remedies that may be available at law in the event of any breach of this
Agreement, each Purchaser shall be entitled to specific performance of the
agreements and obligations of the Company hereunder and to such other injunctive
or other equitable relief as may be granted by a court of competent
jurisdiction.

                8.5     GOVERNING LAW. This Agreement shall be governed by and
construed in accordance with the internal laws of the State of Delaware (without
reference to the conflicts of law provisions thereof).

                                      -9-
<PAGE>

                8.6     NOTICES. All notices, requests, consents, and other
communications under this Agreement shall be in writing and shall be deemed
delivered (i) three business days after being sent by registered or certified
mail, return receipt requested, postage prepaid or (ii) one business day after
being sent via a reputable nationwide overnight courier service guaranteeing
next business day delivery, in each case to the intended recipient as set forth
below: If to the Company, at 13-01 Pollitt Drive, Fair Lawn, New Jersey 07410,
Attention: Dr. Vincent DeCaprio, President, or at such other address as may have
been furnished in writing by the Company to the other parties hereto, with a
copy to Lowenstein Sandler P.C., 65 Livingston Avenue, Roseland, New Jersey
07068-1791, Attention: Peter H. Ehrenberg, Esq.

                                If to a Purchaser, at its address set forth on
EXHIBIT A, or at such other address as may have been furnished in writing by
such Purchaser to the other parties hereto, with a copy to Littman Krooks LLP,
655 Third Avenue, New York, New York 10017, Attention: Mitchell C. Littman, Esq.

                                Any party may give any notice, request, consent
or other communication under this Agreement using commercially reasonable means
(including, without limitation, personal delivery, messenger service, telecopy,
first class mail or electronic mail), but no such notice, request, consent or
other communication shall be deemed to have been duly given unless and until it
is actually received by the party for whom it is intended. Any party may change
the address to which notices, requests, consents or other communications
hereunder are to be delivered by giving the other parties notice in the manner
set forth in this Section.

                8.7     COMPLETE AGREEMENT. This Agreement (including its
exhibits and schedule) constitutes the entire agreement and understanding of the
parties hereto with respect to the subject matter hereof and supersedes all
prior agreements and understandings relating to such subject matter.

                8.8     AMENDMENTS AND WAIVERS. This Agreement may be amended or
terminated and the observance of any term of this Agreement may be waived with
respect to all parties to this Agreement (either generally or in a particular
instance and either retroactively or prospectively), with the written consent of
the Company and the holders of at least 50% of the aggregate amount of principal
under all Notes then held by all Purchasers (the "Requisite Holders").
Notwithstanding the foregoing, (a) this Agreement may not be amended or
terminated and the observance of any term hereunder may not be waived with
respect to any Purchaser without the written consent of such Purchaser unless
such amendment, termination or waiver applies to all Purchasers in the same
fashion, (b) EXHIBIT A hereto may be amended by the Company from time to time in
accordance with Section 2.2 to add information regarding Additional Purchasers
without the consent of the other parties hereto and (c) no amendment of this
Agreement may be made with respect to the Maturity Date or interest rate of a
Note without the consent of the holder thereof. The Company shall give prompt
written notice of any amendment or termination hereof or waiver hereunder to any
party hereto that did not consent in writing to such amendment, termination or
waiver. Any amendment, termination or waiver effected in accordance with this
Section 8.8 shall be binding on all parties hereto, even if they do not execute
such consent. No waivers of or exceptions to any term, condition or provision of
this Agreement, in any one or more instances, shall be deemed to be, or
construed as, a further or continuing waiver of any such term, condition or
provision.

                8.9     PRONOUNS. Whenever the context may require, any pronouns
used in this Agreement shall include the corresponding masculine, feminine or
neuter forms, and the singular form of nouns and pronouns shall include the
plural, and vice versa.

                8.10    COUNTERPARTS; FACSIMILE SIGNATURES. This Agreement may
be executed in any number of counterparts (including, in the case of the
Purchasers, Financing Signature Pages), each of which shall be deemed to be an
original, and all of which shall constitute one and the same document. This
Agreement (including the Financing Signature Pages) may be executed by facsimile
signatures.

                8.11    SECTION HEADINGS AND REFERENCES. The section headings
are for the convenience of the parties and in no way alter, modify, amend, limit
or restrict the contractual obligations of the parties. Any reference in this
agreement to a particular section or subsection shall refer to a section or
subsection of this Agreement, unless specified otherwise. ]

                                      -10-
<PAGE>

        Executed as of the date first written above.

                                        COMPANY:

                                        VYTERIS, INC.

                                        By:     /s/ Vincent De Caprio
                                                ---------------------
                                        Name:   Vincent De Caprio
                                        Title:  President

                                        SPENCER TRASK SPECIALTY GROUP, LLC

                                        By:    /s/ Donald F. Farley
                                               ----------------------
                                               Donald F. Farley
                                               Chief Executive Officer

                                      -11-
<PAGE>

<TABLE>
<CAPTION>
<S>                                                                           <C>

                                                           EXHIBIT A

                                          LIST OF PURCHASERS AND SECURITIES PURCHASED

----------------------------------------- ----------------------------------------- -----------------------------------------
            Name and Address
         OF INITIAL PURCHASERS

----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------
           Name and Address of
         ADDITIONAL PURCHASERS
----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------

----------------------------------------- ----------------------------------------- -----------------------------------------
</TABLE>

                                      -12-
<PAGE>

                                    EXHIBIT B
                            FINANCING SIGNATURE PAGE

        By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Note Purchase Agreement
(the "Purchase Agreement") by and among Vyteris, Inc., a Delaware corporation
(the "Company"), and the Purchasers (as defined in the Purchase Agreement),
dated as of the Closing Date (as defined in the Purchase Agreement),
acknowledges having read the representations in the Purchase Agreement section
entitled "Representations of the Purchasers," and hereby represents that the
statements contained therein are complete and accurate with respect to the
undersigned as a Purchaser. The undersigned further hereby agrees to be bound by
the terms and conditions of the (i) Purchase Agreement as a "Purchaser"
thereunder, (ii) the Security Agreement and (iii) the Warrant Agreement and
authorizes this signature page to be attached to the Purchase Agreement.

        Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By:___________________________________
                                               Name of Purchaser

                                        By:___________________________________

                                        Title: _______________________________
                                        Date: ________________________________
                                        Contact Person: ______________________
                                        Telephone No.: _______________________
                                        Fax No.:  ____________________________
                                        E-mail Address:  _____________________

                                      -13-
<PAGE>

                                    EXHIBIT C
                     FORM OF 11.5% SENIOR SECURED GRID NOTE

<PAGE>

                         11.5% SENIOR SECURED GRID NOTE

New York, New York                                           _________ __, 200__

This Note is issued pursuant to, and is subject to the terms and conditions of
the Securities Purchase Agreement dated as of September __, 2004 with respect to
11.5% Senior Secured Grid Notes among Vyteris, Inc. and the Initial Purchasers
named therein ("Purchase Agreement").

1.      DEFINITIONS. For purposes of this Note:

        A.      AVAILABLE LOAN AMOUNT. The "Available Loan Amount" means, at any
one point in time, the sum of (a) all accounts receivable less than 60 days past
due relating to the purchase of Inventory (as hereinafter defined) from the
Borrower; and (b) the cost of Inventory owned by the Borrower, inclusive of raw
materials, work-in-process and finished goods, as calculated in accordance with
generally accepted accounting principles.

        B.      BORROWER. The "Borrower" means Vyteris, Inc., a Delaware
corporation residing at or having its chief executive office at 847 13-01
Pollitt Drive, Fair Lawn, New Jersey 07410.

        C.      COLLATERAL. "Collateral" means any collateral, subordination,
guaranty, endorsement or other security or assurance of payment, whether now
existing or hereafter arising or accruing, that now or hereafter secures the
payment of or is otherwise applicable to the Outstanding Principal Account or
any interest or other amount payable pursuant to this Note and remaining unpaid.

        D.      CREDIT. The "Credit" means a loan limit made available by the
Lender to the Borrower in the maximum principal amount equal to the Limiting
Principal Amount.

        E.      EVENT OF DEFAULT. "Event of Default" shall have the meaning set
forth in Section 8 hereof.

        F.      HOLDER. The "Holder" means the Lender or any transferee of this
Note., provided that any transferee shall have executed an assumption agreement
pursuant to which the transferee shall have unconditionally assumed the
obligations of the Holder under this Note and the other Transaction Documents
relating to this Note.

        G.      INTEREST. "Interest" shall have the meaning set forth in Section
3 hereof.

        H.      LENDER. The "Lender" means Spencer Trask Specialty Group, LLC, a
Delaware limited liability company, having its chief executive office at 535
Madison Avenue, New York, New York 10022.

        I.      LIMITING PRINCIPAL AMOUNT. "Limiting Principal Amount" means
$5,000,000.

<PAGE>

        J.      LOAN. "Loan" means any loan by the Holder pursuant to the
Credit.

        K.      MATURITY DATE. The "Maturity Date" shall be November 15, 2005.

        L.      OUTSTANDING PRINCIPAL AMOUNT. The "Outstanding Principal Amount"
means the outstanding principal amount of this Note.

        M.      TRANSACTION DOCUMENTS. The "Transaction Documents" shall mean
this Note, the Purchase Agreement and the Security Agreement as defined in
Section 9 hereof.

2.      PROMISE TO PAY. The principal amount plus all accrued and unpaid
interest owing under this Note shall be paid on the Maturity Date; PROVIDED,
HOWEVER, this Note shall be prepaid from the proceeds received by the Borrower
from the sale of its inventory (the "Inventory") prior to the Maturity Date. The
Borrower agrees that beginning on the date hereof all payments to the Borrower
by account ("Accounts") relating to their purchases of Inventory from the
Borrower are to be made directly to the "lock box" account designated in
SCHEDULE A hereto until further notice from the Holder. The Borrower shall not
contradict such instructions until such time as the Outstanding Principal Amount
and accrued but unpaid interest is paid. The Borrower also agrees to transfer
promptly, and in no event later than three (3) business days after receipt, to
the Lender all payments received directly by the Borrower from the Accounts by
wire transfer to the account designated on SCHEDULE A hereto in immediately
available funds in U.S. Dollars. All funds deposited into the "lock-box" account
shall be applied as prepayments to this Note (which shall be applied first to
interest and then to principal hereunder). Such prepayment amounts may be
re-borrowed by the Borrower pursuant to a valid borrowing request to the lender
in the form attached hereto as SCHEDULE B and Holder shall lend those sums to
the Borrower. The Borrower agrees to use commercially reasonable efforts to
collect any and all monies from Accounts. The Holder shall have the right to
100% of the monies sent to the "lock box" account designated in SCHEDULE A
hereto or otherwise received by Spencer Trask Specialty Group, LLC ("STSG") in
respect of the Accounts for application to the outstanding balance of this Note.
This Note, and all representations, warranties, covenants and agreements
contained herein, shall be binding upon the Borrower and its successors and
permitted assigns and shall inure to the benefit of the Lender and its
successors and assigns. The Borrower may not assign or delegate any of its
duties or obligations under this Note without the written consent of the Holder,
which shall not be unreasonably withheld.

3.      INTEREST. Interest, calculated on the basis of a 360-day year for the
actual calendar days elapsed (365 or 366, as applicable), on the Outstanding
Principal Amount from and including the date of this Note to but not including
the date the Outstanding Principal Amount is paid in full at a rate per year
that shall on each day be 11.5% (provided, however, that (i) in no event shall
such interest be payable at a rate in excess of the maximum rate permitted by
applicable law and (ii) solely to the extent necessary to result in such
interest not being payable at a rate in excess of such maximum rate, any amount
that would be treated as part of such interest under a final judicial
interpretation of applicable law shall be deemed to have been a mistake and
automatically canceled, and, if received by the Holder, shall be refunded to the
Borrower, it being the intention of the Lender and the Borrower that such
interest not be payable at a rate in excess of such maximum rate) (the
"Interest").

                                      - 2 -
<PAGE>

        The Outstanding Principal Amount and accrued and unpaid Interest
outstanding as of the Maturity Date shall automatically become due and payable
on the Maturity Date.

4.      PAYMENTS WITHOUT PREMIUM OR PENALTY. The Borrower shall have the option
before the Maturity Date or upon the occurrence of an Event of Default of paying
the Outstanding Principal Amount to the Holder in full or part at any time and
from time to time without any premium or penalty.

5.      SCHEDULE OF ADVANCES OR LOAN ACCOUNT. There shall be payable as
principal pursuant to this Note only so much of the Limiting Principal Amount as
shall have been advanced by the Holder as a Loan or Loans and is outstanding.
The Holder shall set forth on the schedule attached to and made a part of this
Note or any similar schedule or loan account (including, but not limited to, any
similar schedule or loan account maintained in computerized records) annotations
evidencing (a) the date and principal amount of each Loan, (b) the date and
amount of each payment applied to the Outstanding Principal Amount and (c) the
Outstanding Principal Amount after each Loan and each such payment. Each such
annotation shall, in the absence of manifest error, be conclusive and binding
upon the Borrower. No failure by the Holder to make and no error by the Holder
in making any annotation on such attached schedule or any such similar schedule
or loan account shall affect the Borrower's obligation to repay the principal
amount of each Loan, the Borrower's obligation to pay interest on the
outstanding principal amount of each Loan or any other obligation of the
Borrower to the Holder pursuant to this Note or otherwise. At such time as the
Borrower wishes to receive a Loan, a request shall be submitted to Holder in the
form attached hereto as SCHEDULE B, certified as correct by the Borrower's Chief
Executive Officer and Chief Financial Officer.

6.      LIMITATION ON OUTSTANDING PRINCIPAL AMOUNT. The Borrower shall not at
any time permit, and the Lender shall not at any time be obligated to permit,
the Outstanding Principal Amount to exceed the Limiting Principal Amount, or, if
less, the Available Loan Amount.

7.      AMOUNTS IMMEDIATELY DUE. The Outstanding Principal Amount and all
Interest and other amounts payable pursuant to this Note and remaining unpaid
shall, without any notice, demand, presentment or protest of any kind (each of
which is knowingly, voluntarily, intentionally and irrevocably waived by the
Borrower), automatically become immediately due upon the occurrence of any Event
of Default.

8.      EVENTS OF DEFAULT. If any one or more of the following events (each, an
"Event of Default") shall occur, that is to say:

        A.      The Borrower shall fail to make any payment in respect of
interest (including additional interest) on or principal of this Note within
five (5) days of becoming due, whether at maturity or by acceleration or
otherwise; or

        B.      Any default or event of default shall occur with respect to any
other indebtedness of the Borrower exceeding $100,000 which results in any
payment with respect to such indebtedness for borrowed money becoming due prior
to its stated maturity; or

                                      - 3 -
<PAGE>

        C.      A final judgment which, in the aggregate with other outstanding
final judgments against the Borrower, exceeds $100,000 shall be rendered against
the Borrower and, if within 45 days after entry thereof, such judgment shall not
have been discharged or stayed pending appeal, or within 45 days after
expiration of such stay such judgment shall not have been discharged; or

        D.      The Borrower shall:

                (i)     commence a voluntary case under Title 11 of the United
States Code as from time to time in effect, or authorize, by appropriate
proceedings of its board of directors, the commencement of such a voluntary
case;

                (ii)    have filed against it a petition commencing an
involuntary case under said Title 11 which is not dismissed or vacated within 90
days after the date the same is filed;

                (iii)   seek relief as a debtor under any applicable law, other
than said Title 11, of any jurisdiction relating to the liquidation or
reorganization of debtors or to the modification or alteration of the rights of
creditors, or consent to or acquiesce in such relief;

                (iv)    have entered against it any order by a court of
competent jurisdiction (i) finding it to be bankrupt or insolvent, (ii) ordering
or approving its liquidation, reorganization or any modification or alteration
of the rights of its creditors, or (iii) assuming custody of, or appointing a
receiver or other custodian for, all or a substantial part of its property and,
in the case of clause (ii) or (iii), any such order shall not have been vacated
or rescinded within 90 days after the date such order was entered; or

                (v)     make an assignment for the benefit of, or enter into a
composition with, its creditors, or appoint or consent to the appointment of a
receiver or other custodian for all or a substantial part of its property; or

        E.      The Borrower shall have breached in any material respect any
representation, warranty, covenant or obligation contained in the Transaction
Documents and, if capable of cure, such breach continues for ten (10) days after
the Holder gives notice of such breach to the Borrower;

        F.      The security interest granted to the Holder shall not be less
than a first priority security interest in the Collateral;

then, and in each and every case, the Holder may declare the Outstanding
Principal Amount of this Note to be immediately due and payable, and thereupon
the Outstanding Principal Amount, together with Interest accrued thereon, shall
become so due and payable without presentation, presentment, protest or further
demand or notice of any kind, all of which are hereby expressly waived, and the
Holder may proceed to enforce payment of such amount in such manner as it may
elect.

9.      SENIOR SECURED RIGHTS TO COLLATERAL. This Note shall be secured by that
certain Security Agreement (the "Security Agreement") by and among the Lender
and the Borrower, dated of even date herewith, as may be amended from time to
time.

                                      - 4 -
<PAGE>

        The indebtedness evidenced by this Note and the payment of the
Outstanding Principal Amount hereof shall be Senior (as hereinafter defined) to,
and have priority in right of payment over, all indebtedness of Borrower for
borrowed money, outstanding as of the date hereof or hereinafter incurred, other
than purchase money equipment financing. "Senior" as used herein shall be deemed
to mean that, in the event of any default in the payment of the obligations
represented by this Note (after giving effect to "cure" provisions, if any) or
of any liquidation, insolvency, bankruptcy, reorganization, or similar
proceedings relating to the Company, all sums payable on this Note shall first
be paid in full, with interest, if any, before any payment is made upon any
other indebtedness for borrowed money, other than purchase money equipment
financing, now outstanding or hereinafter incurred, and, in any such event, any
payment or distribution of any character which shall be made in respect of any
other indebtedness of the Company shall be paid over to the Lender of this Note
for application to the payment hereof, unless and until the obligations under
this Note (which shall mean the principal and other obligations arising out of,
premium, if any, interest on, and any costs and expenses payable under, this
Note) shall have been paid and satisfied in full.

10.     NO OTHER SENIOR INTERESTS. Except for (i) the rights of Becton,
Dickinson and Company ("Becton") to receive certain royalties in respect of
certain products developed using certain intellectual property rights
transferred by Becton pursuant to Section 8.05 of that certain Transaction
Agreement, by and between Becton, Spencer Trask Specialty Group, LLC, Spencer
Trask Ventures, Inc. and the Grantor, dated November 10, 2000, (ii) the rights
of B. Braun Medical Inc. to certain distribution and license rights to use the
Borrower's Trademarks, Patents (each as defined in the Security Agreement) and
related intellectual property rights pertaining to the Borrower's transdermal
lidocaine delivery system pursuant to Section 2 of that certain License,
Development and Distribution Agreement, dated September 20, 2002 and (iii)
purchase money liens against equipment, the Borrower owns each of the General
Assets, Trademarks, Patents and Licenses (each as defined in the Security
Agreement) free and clear of any and all liens, claims or security or adverse
interests to all or any of the Trademarks, Patents and Licenses free and clear
of any and all liens, claims or security or adverse interests to all or any of
the Trademarks, Patents and Licenses on file or of record in any public office,
except as such as have been filed in favor of the Lender pursuant to this
Agreement.

11.     The Borrower hereby covenants and agrees, so long as any amount remains
outstanding pursuant to this Note:

        A.      It will not grant or attempt to grant any person or entity a
security interest in the Collateral or any portion thereof senior to, with
priority over, or PARI PASSU with the security interest granted to the Lender
pursuant to the Security Agreement.

        B.      It will not pledge or attempt to pledge the Collateral or any
portion thereof to any person or entity.

12.     GOVERNING LAW. This Note shall be governed by and construed, interpreted
and enforced in accordance with the law of the State of Delaware and the federal
law of the United States without regard to the law of any other jurisdiction.

                                      - 6 -
<PAGE>

13.     WAIVER OF TRIAL BY JURY AND CLAIMS TO CERTAIN DAMAGES. THE BORROWER
KNOWINGLY, VOLUNTARILY, INTENTIONALLY AND IRREVOCABLY WAIVES EACH RIGHT THE
BORROWER MAY HAVE TO A TRIAL BY JURY WITH RESPECT TO, AND EACH RIGHT TO ASSERT
ANY CLAIM FOR DAMAGES (INCLUDING, BUT NOT LIMITED TO, PUNITIVE DAMAGES) IN
ADDITION TO ACTUAL DAMAGES IN, ANY ACTION OR OTHER LEGAL PROCEEDING, WHETHER
BASED ON ANY CONTRACT OR NEGLIGENT, INTENTIONAL OR OTHER TORT OR OTHERWISE,
ARISING OUT OF OR OTHERWISE RELATING TO (A) THE CREDIT, ANY LOAN OR COLLATERAL,
THIS NOTE OR ANY OTHER WRITING HERETOFORE OR HEREAFTER EXECUTED IN CONNECTION
WITH THE CREDIT OR ANY LOAN OR COLLATERAL, (B) ANY TRANSACTION ARISING OUT OF OR
OTHERWISE RELATING TO THE CREDIT, ANY LOAN OR COLLATERAL, THIS NOTE OR ANY SUCH
OTHER WRITING OR (C) ANY NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT
OF THE CREDIT, ANY LOAN OR COLLATERAL, THIS NOTE OR ANY SUCH OTHER WRITING.

                                   VYTERIS, INC.

                                   By:    _____________________________________
                                          Name:
                                          Title:

                                      - 6 -
<PAGE>

                        SCHEDULE OF ADVANCES AND PAYMENTS

                  Principal
                    Amount                                        Outstanding
Date Advanced      Advanced      Date Paid     Amount Paid     Principal Amount
-------------      --------      ---------     -----------     ----------------

                                      - 7 -
<PAGE>

                                   SCHEDULE A

Bank name and address:          ____________________________
                                ____________________________
                                ____________________________

Account title:

Account Number:

                                      - 8 -

<PAGE>

                                   SCHEDULE B

                         VYTERIS, INC. BORROWING REQUEST

Date:________________________

To:  Spencer Trask Specialty Group, LLC

As of the date of this request, the following is correct and true to the best of
the undersigned's knowledge and belief:

(a) Total amount of accounts receivable owing to us from the sale of inventory
which are not more that sixty (60) days past due is: ___________________________

(b) Cost of our inventory, in accordance with GAAP, is:

        Raw materials:    ________________
        Work in process:  ________________
        Finished goods:   ________________
        Total inventory:  ________________

(c) Total of (a) and (b) above:________________ ("Available Loan Amount")

(d) Amount of loans currently outstanding:________________

(e) Maximum amount we can borrow, (c) minus (d):$____________

(f) The undersigned hereby requests a loan in the principal amount of
$________________, which is not in excess of $5,000,000 or, if less, the amount
shown in (e) above.

_____________________________________      _____________________________________
Signature of Chief Executive Officer       Signature of Chief Financial Officer

                                      - 9 -

<PAGE>

                                    EXHIBIT D
                                 FORM OF WARRANT

                                      -15-
<PAGE>

                          [FORM OF WARRANT CERTIFICATE]

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR THE SECURITIES LAWS OF
ANY STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT PURSUANT TO (i) AN
EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES
LAWS OR (ii) AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO THE ISSER, THAT
AN APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH
LAWS IS AVAILABLE.

THE TRANSFER, EXCHANGE AND EXERCISE OF THE WARRANTS REPRESENTED BY THIS
CERTIFICATE ARE RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO
HEREIN.

No. St-__
                                                                 _______Warrants
                                                          _____________ __, 200_

                               WARRANT CERTIFICATE

        This Warrant Certificate certifies that _________________________, or
its registered assigns, is the registered holder of ____________________warrants
(the "Warrants") to purchase initially, at any time after the date hereof
("Warrant Issue Date") until 5:30 p.m. New York time on September __, 2009 (the
"Expiration Date"), up to ___________ fully paid and non-assessable shares of
Common Stock, $0.0001 par value per share ("Common Stock") of the Company, at
the initial exercise price, subject to adjustment in certain events (the
"Exercise Price"), of $1.50 upon surrender of this Warrant Certificate and
payment of the Exercise Price at an office or agency of the Company, or by
surrender of this Warrant Certificate in lieu of cash payment, but subject to
the conditions and adjustments set forth in the Warrant Agreement dated as of
___________ ___, 200_ entered into by and among the Company and each holder of
Warrants (the "Warrant Agreement"). Except as otherwise provided in Section 3.2
of the Warrant Agreement, payment of the Exercise Price shall be made by
certified or official bank check in New York Clearing House funds payable to the
order of the Company.

        No Warrant may be exercised after 5:30 p.m. (New York time) on the
Expiration Date, at which time the Warrants evidenced hereby, unless exercised
prior thereto, shall thereafter be void.

        The Warrants evidenced by this Warrant Certificate are part of a duly
authorized issue of Warrants issued pursuant to the Warrant Agreement, which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and to which reference is hereby made for a description of the
rights, limitations of rights, obligations, duties and immunities thereunder of
the Company and the registered holder(s) of the Warrants.

<PAGE>

        As set forth in Section 7 of in the Warrant Agreement, certain
adjustments may be made to the Exercise Price and the type and/or number of the
Company's securities issuable upon their exercise. In the event of such an
adjustment, the Company will, at the request of the holder, issue a new Warrant
Certificate evidencing the adjustment in the Exercise Price and the number
and/or type of securities issuable upon the exercise of the Warrants; PROVIDED,
HOWEVER, that the failure of the Company to issue such new Warrant Certificates
shall not in any way change, alter or otherwise impair the rights of the holder
as set forth in the Warrant Agreement.

        Upon due presentment of transfer of this Warrant Certificate and the
executed form of assignment attached hereto at an office or agency of the
Company, a new Warrant Certificate or Warrant Certificates of like form and
tenor and evidencing in the aggregate a like number of Warrants shall be issued
to the transferee(s) in exchange for this Warrant Certificate, subject to the
limitations provided herein and in the Warrant Agreement, without any charge
except for any tax or other governmental charge imposed in connection with such
transfer.

        Upon the exercise of less than all of the Warrants evidenced by this
Warrant Certificate, the Company shall forthwith issue to the holder hereof a
new Warrant Certificate representing such number of unexercised Warrants.

        The Company may deem and treat the registered holder(s) hereof as the
absolute owner(s) of this Warrant Certificate (notwithstanding any notation of
ownership or other writing hereon made by anyone), for the purpose of any
exercise hereof, and of any distribution to the holder(s) hereof, and for all
other purposes, and the Company shall not be affected by any notice to the
contrary.

        All capitalized terms used and not defined in this Warrant Certificate
shall have the meanings ascribed to them in the Warrant Agreement.

            [THE REMAINDER OF THIS PAGE IS INTENTIONALLY LEFT BLANK]

                                       2
<PAGE>

        IN WITNESS WHEREOF, the Company has caused this Warrant Certificate to
be duly executed as of _____________ __, 200_.

                                            VYTERIS, INC.

                                            By: ________________________________
                                                Name: Vincent L. DeCaprio, Ph.D.
                                                Title: President

Attest:

__________________________
Secretary

                                       3

<PAGE>

                         [FORM OF ELECTION TO PURCHASE]

TO:     Vyteris, Inc.
        Attention:  President

        1.      The undersigned hereby irrevocably elects to exercise the right,
represented by the attached Warrant Certificate, to purchase _______________
(leave blank if you choose Alternative No. 2 below) shares of Common Stock
pursuant to the terms of the Warrant Agreement entered into by and among
Vyteris, Inc. and the holders of the Warrants, dated __________ ___, 200__ (the
"Warrant Agreement"), and tenders herewith payment of the purchase price of such
shares in full. (Initial here if the undersigned elects this alternative).
_________

        2.      In lieu of exercising the attached Warrant Certificate for cash
or check, the undersigned hereby elects to effect the net exercise provision set
forth in Section 3.2 of the Warrant Agreement and receive ____________ (leave
blank if you choose Alternative No. 1 above) shares of Common Stock of the
Company. (Initial here if the undersigned elects this alternative). ___________

        Capitalized terms used and not herein defined shall have the meanings
ascribed to them in the Warrant Agreement.

        Please issue a certificate or certificates representing said securities
in the name of the undersigned or in such other name as is specified below:

                 ---------------------------------------------
                                     (Name)

                 ---------------------------------------------

                 ---------------------------------------------

                                    (Address)

                                    --------------------------------------------
                                    (Signature and Date)

                                    (Signature must conform in all respects to
                                    name of holder as specified on the face of
                                    the Warrant Certificate)

                                    --------------------------------------------
                                    (Insert Social Security or Other Identifying
                                    Number of Holder)

<PAGE>

                              [FORM OF ASSIGNMENT]

             (To be executed by the registered holder if such holder
                  desires to transfer the Warrant Certificate)

        FOR VALUE RECEIVED ________________________________ (the "Transferor")
hereby sells, assigns and transfers unto _____________________________________
(the "Transferee")

                  (Please print name and address of transferee)

        this Warrant Certificate, together with all right, title and interest
therein, and does hereby irrevocably constitute and appoint
______________________ as its Attorney to transfer the within Warrant
Certificate on the books of Vyteris, Inc., with full power of substitution. The
Transferor has provided a written instrument to the Company notifying the
Company of such transfer and pursuant to which the Transferee hereunder has
agreed in writing to be bound by the terms of the Warrant Agreement dated
__________ __, 200__ by, between and among Vyteris, Inc., a Delaware
corporation, and the holders of the Warrants a copy of which has been provided
to the Transferee by the Transferor.

Dated:                               Signature__________________________________
                                     (Signature must conform in all respects to
                                     name of holder as specified on the face of
                                     the Warrant Certificate)

                                     ___________________________________________
                                     (Insert Social Security or other
                                     Identifying Number of Holder)

<PAGE>

                                    EXHIBIT E
                           FORM OF SECURITY AGREEMENT

<PAGE>

                               SECURITY AGREEMENT

        This SECURITY AGREEMENT (this "Agreement"), dated as of September 28,
2004 is made by and between Vyteris, Inc., a Delaware corporation ("Vyteris" or
the "Grantor") and the holders (the "Noteholders") of certain 11.5% senior
secured grid notes (each, a "Note" and collectively, the "Notes") to be issued
by Vyteris from time to time on and after the date hereof, all upon terms set
forth in that certain Securities Purchase Agreement, dated September 28, 2004
(the "SPA").

                              W I T N E S S E T H:

        WHEREAS, pursuant to its execution of a Signature Financing Page in the
form attached to the SPA as EXHIBIT B, each such subscriber has become a
Noteholder, and has agreed to be subject to the terms of this Agreement;

        WHEREAS, it is a condition precedent to the obligation of each of the
subscribers of Notes to purchase a Note that the Grantor shall have agreed to
grant such Noteholders a future security interest in the Collateral (as
hereinafter defined) as contemplated by this Agreement; and

        WHEREAS, the Grantor expects to realize direct and indirect benefits as
a result of the sale of the Notes to the subscribers;

        NOW, THEREFORE, for good and valuable consideration, the receipt and
adequacy of which hereby is acknowledged, the Grantor hereby represents,
warrants, covenants, agrees, assigns and grants as follows:

                            ARTICLE I - DEFINITIONS

        1.1     This Agreement is the Security Agreement referred to in the
Notes. As used in this Agreement, the following terms shall have the meanings
respectively set forth below:

        "Agreement" means this Security Agreement, and any extensions,
modifications, renewals, restatements, supplements or amendments hereof.

        "Bankruptcy Code" means Chapter 11 of Title 11 of the United States
Code, as amended from time to time, and any successor statute and all rules and
regulations promulgated thereunder.

        "Collateral" means all of the Grantor's now owned or hereafter acquired
right, title and interest in and to the General Assets, the Trademarks, the
Patents and the Licenses.

        "General Assets" shall have the meaning set forth in Section 2.1 hereof.

        "Licenses" shall have the meaning set forth in Section 2.4 hereof.

<PAGE>

        "Patents" shall have the meanings set forth in Section 2.3 hereof.

        "Secured Obligations" means any and all present and future obligations
of the Grantor arising under or relating to the Notes or this Agreement, whether
due or to become due, matured or unmatured, or liquidated or unliquidated,
including interest that accrues after the commencement of any bankruptcy or
insolvency proceeding by or against the Grantor.

        "Trademarks" shall have the meanings set forth in Section 2.2 hereof.

                         ARTICLE II -SECURITY INTERESTS

                2.1     GRANT OF SECURITY INTEREST IN GENERAL ASSETS. To secure
the complete and timely payment, performance and satisfaction of all of the
Secured Obligations, the Grantor hereby grants to the Noteholders, a security
interest over all other security interests (except as expressly set forth in
this Agreement), with power of sale to the fullest extent permitted by
applicable law, in all of the Grantor's right, title and interest in and to the
Grantor's now owned or otherwise existing and hereafter acquired or arising:

                (a)     accounts, contract rights and all other forms of
        obligations owing to the Grantor arising out of the sale or lease of
        goods or the rendition of services by the Grantor, irrespective of
        whether earned by performance, and any and all credit insurance,
        guarantees or security therefor;

                (b)     books and records, including ledgers; records
        indicating, summarizing or evidencing the Grantor's properties or assets
        or liabilities; all information relating to the Grantor's business
        operations or financial condition; and all other computer programs, disk
        or tape files, printouts, runs or other computer prepared information;

                (c)     deposit accounts (as that term is defined from time to
        time in the Uniform Commercial Code as in effect in the State of
        Delaware);

                (d)     all of the Grantor's general intangibles and other
        personal property (including contract rights, rights arising under
        common law, statutes or regulations, choses or things in action,
        commercial tort claims, blueprints, drawings, purchase orders, customer
        lists, monies due or recoverable from pension funds, route lists,
        computer programs, information contained in computer disks or tapes,
        literature, reports, catalogs, insurance premium rebates, tax refunds
        and tax refund claims);

                (e)     goods (as that term is defined from time to time in the
        Uniform Commercial Code as in effect in the State of Delaware),
        including, without limitation, (i) all inventory, including, without
        limitation, equipment held for lease, whether raw materials, in process
        or finished, all material or equipment usable in processing the same and
        all documents of title covering any inventory, (ii) all equipment
        employed in connection with the Grantor's business, together with all
        present and future additions,

<PAGE>

        attachments and accessions thereto and all substitutions therefor and
        replacements thereof, and (iii) all vehicles;

                (f)     instruments and other investment property (as such terms
        are defined from time to time in the Uniform Commercial Code as in
        effect in the State of Delaware);

                (g)     negotiable collateral, including all of the Grantor's
        right, title and interest with respect to any letters of credit, letter
        of credit rights, instruments, drafts, documents and chattel paper (as
        each term is defined from time to time in the Uniform Commercial Code as
        in effect in the State of Delaware), and any and all supporting
        obligations in respect thereof;

                (h)     all parcels of real property and the related
        improvements thereto (whether as owner, lessee or otherwise);

                (i)     money or other assets of the Grantor that now or
        hereafter come into the possession, custody or control of the Grantor;

                (j)     the proceeds and products, whether tangible or
        intangible, of any of the foregoing, including proceeds of insurance
        covering any or all of the foregoing, and any and all of the foregoing,
        or other tangible or intangible property resulting from the sale,
        exchange, collection or other disposition of any of the foregoing, or
        any portion thereof or interest therein, and the proceeds thereof; and

                (k)     all of the Grantor's right, title and market in and to
        any shares of capital stock of any of its subsidiaries and the
        certificates representing any such shares

all of the items described in clauses (a)-(k) in this Section 2.1, are
hereinafter individually and/or collectively referred to as the "General
Assets".

                2.2     GRANT OF SECURITY INTEREST IN TRADEMARKS. To secure the
complete and timely payment, performance and satisfaction of all of the Secured
Obligations, the Grantor hereby grants to the Noteholders, a security interest
as and by way of a first mortgage and security interest having priority over all
other security interests, including, without limitation, with power of sale to
the fullest extent permitted by applicable law, in all of the Grantor's right,
title and interest in and to the Grantor's now owned or otherwise existing and
hereafter acquired or arising: trademarks, trade names, registered trademarks,
trademark applications, service marks, registered service marks and service mark
applications; (i) all renewals thereof, (ii) all income, royalties, damages and
payments now and hereafter due and/or payable under and with respect to thereto,
including, without limitation, payments under all licenses entered into in
connection therewith and damages and payments for past or future infringements
or dilutions thereof, (iii) the right to sue for past, present and future
infringements and dilutions thereof, (iv) the goodwill of the Grantor's business
symbolized by the foregoing and connected therewith and (v) all of the Grantor's
rights corresponding thereto throughout the world (all of the foregoing
trademarks, trade names, registered trademarks and trademark applications,

<PAGE>

service marks, registered service marks and service mark applications, together
with the items described in clauses (i)-(v) in this Section 2.2, are hereinafter
individually and/or collectively referred to as the "Trademarks"); and (b) all
proceeds of any and all of the foregoing, including, without limitation, license
royalties and proceeds of the infringement suits.

                2.3     GRANT OF SECURITY INTEREST IN PATENTS. To secure the
complete and timely payment, performance and satisfaction of all of the Secured
Obligations, the Grantor hereby grants to the Noteholders, a security interest
as and by way of a first mortgage and security interest having priority over all
of other security interests, including, without limitation, with power of sale
to the fullest extent permitted by applicable law, in all of the Grantor's
right, title and interest in and to the Grantor's now owned or otherwise
existing and hereafter acquired or arising: patents and patent applications and
(i) all renewals thereof, (ii) all income, royalties, damages and payments now
and hereafter due and/or payable under and with respect to thereto, including,
without limitation, payments under all licenses entered into in connection
therewith and damages and payments for past or future infringements or dilutions
thereof, (iii) the right to sue for past, present and future infringements and
dilutions thereof, (iv) the goodwill of the Grantor's business symbolized by the
foregoing and connected therewith and (v) all of the Grantor's rights
corresponding thereto throughout the world (all of the foregoing patents and
patent applications, together wit the items described in clauses (i)-(v) in this
Section 2.3, are hereinafter individually and/or collectively referred to as the
"Patents"); and (b) all proceeds of any and all of the foregoing, including,
without limitation, license royalties and proceeds of the infringement suits.

                2.4     GRANT OF SECURITY INTEREST IN TRADEMARK AND PATENT
LICENSES. To secure the complete and timely payment, performance and
satisfaction of all of the Secured Obligations, the Grantor hereby grants to the
Noteholders, a security interest, as and by way of a first mortgage and security
interest having priority over all of other security interests, including,
without limitation, with power of sale to the fullest extent permitted by
applicable law, in all of the Grantor's right, title and interest in and to the
Grantor's now owned or otherwise existing and hereafter acquired or arising:
rights under or interests in any license agreements with any other party,
whether the Grantor is a licensee or licensor under any such license agreement,
and the right to use the foregoing in connection with the enforcement of the
Noteholders' rights under the Notes, including, without limitation, the right to
prepare for sale and sell any and all inventory now or hereafter owned by the
Grantor and now or hereafter covered by such licenses (all of the foregoing are
hereinafter referred to collectively as the "Licenses"). Notwithstanding the
foregoing provisions of this Section 2.4, the Licenses shall not include any
license agreement in effect as of the date hereof that by its terms expressly
prohibits the grant of the security contemplated by this Agreement: PROVIDED,
HOWEVER, that upon the termination of such prohibitions for any reason
whatsoever, the provisions of this Section 2.4 shall be deemed to apply thereto
automatically.

                2.5     TITLE; OTHER LIENS. Except for (i) the rights of Becton,
Dickinson and Company ("Becton") to receive certain royalties in respect of
certain products developed using certain intellectual property rights
transferred by Becton pursuant to Section 8.05 of that certain Transaction
Agreement, by and between Becton, Spencer Trask Specialty Group, LLC, Spencer

<PAGE>

Trask Ventures, Inc. and the Grantor, dated November 10, 2000, and (ii) the
rights of B. Braun Medical Inc. to certain distribution and license rights to
use the Trademarks, Patents and related intellectual property rights pertaining
to the Grantor's transdermal lidocaine delivery system pursuant to Section 2 of
that certain License, Development and Distribution Agreement, dated September
20, 2002, the Grantor owns each of the General Assets, Trademarks, Patents and
Licenses free and clear of any and all liens, claims or security or adverse
interests to all or any of the Trademarks, Patents and Licenses free and clear
of any and all liens, claims or security or adverse interests to all or any of
the Trademarks, Patents and Licenses on file or of record in any public office,
except as such as have been filed in favor of the Noteholders pursuant to this
Agreement. The parties acknowledge that Grantor may grant future first priority
purchase money security interest in equipment to secure purchase money financing
of such equipment.

                        ARTICLE III - FURTHER ASSURANCES

                3.1     At any time and from time to time at the request of the
Noteholders, the Grantor shall execute and deliver to the Noteholders all such
financing statements and other instruments and documents in form and substance
satisfactory to the Noteholders as shall be necessary or desirable to fully
perfect, when filed and/or recorded, the security interest granted to the
Noteholders pursuant to ARTICLE II of this Agreement. The Grantor hereby
authorizes the Noteholders, without notice to the Grantor, to file any financing
statement and amendments thereof or continuations thereof, naming the Grantor as
debtor and the Noteholders as the creditors. At any time and from time to time,
the Noteholders shall be entitled to file and/or record any or all such
financing statements, instruments and documents held by them, and any or all
such further financing statements, documents and instruments, and to take all
such other actions, as the Noteholders may deem appropriate to perfect and to
maintain perfected the security interest granted to the Noteholders in ARTICLE
II of this Agreement. Before and after the occurrence of any default under the
Notes, at the Noteholders' request, the Grantor shall execute all such further
financing statements, instruments and documents, and shall do all such further
acts and things, as may be deemed necessary or desirable by the Noteholders to
create and perfect, and to continue and preserve, an indefeasible security
interest in the Collateral in favor of the Noteholders or the priority thereof,
including causing any such financing statements to be filed and/or recorded in
the applicable jurisdiction.

                         ARTICLE IV - SECURITY AGREEMENT

                4.1     This Agreement secures the payment of all of the Secured
Obligations of the Grantor now or hereafter existing under the Notes, whether
for principal, interest, fees, expenses or otherwise, and all of the Secured
Obligations of the Grantor now or hereafter existing under this Agreement and
provides for the application of proceeds from the Collateral, upon the
occurrence of an Event of Default, to satisfy the Secured Obligations.

                         ARTICLE V - EVENTS OF DEFAULT

                5.1     There shall be an Event of Default (as defined in the
Notes) hereunder upon the occurrence and during the continuance of an Event of
Default under any of the Notes. The

<PAGE>

Grantor shall promptly notify the Noteholders in writing of any occurrence of an
Event of Default.

                    ARTICLE VI - RIGHTS UPON EVENT OF DEFAULT

                6.1     Upon the occurrence and during the continuance of an
Event of Default, the Noteholders shall have, in any jurisdiction where
enforcement hereof is sought, in addition to all other rights and remedies that
the Noteholders may have under applicable law or in equity or under this
Agreement, all rights and remedies of a secured party under the Uniform
Commercial Code as enacted in any jurisdiction.

                  ARTICLE VII - VOTING RIGHTS; DIVIDENDS; ETC.

                7.1     With respect to Grantor's right, title and interest to
any Collateral consisting of securities, partnership interests, joint venture
interests, investments or the like (referred to collectively and individually in
this Article VII and in Article VIII as the "Investment Collateral"), so long as
no Event of Default occurs and remains continuing:

                (a)     the Grantor shall be entitled to exercise any and all
        voting and other consensual rights pertaining to the Investment
        Collateral, or any part thereof, for any purpose not inconsistent with
        the terms of this Agreement or the Notes; and

                (b)     the Grantor shall be entitled to receive and to retain
        and use any and all dividends or distributions paid in respect of the
        Investment Collateral.

                  ARTICLE VIII - RIGHTS DURING EVENT OF DEFAULT

                8.1     With respect to any Investment Collateral in the
possession of the Grantor, so long as an Event of Default has occurred and is
continuing:

                (a)     at the option of the Noteholders, all rights of the
        Grantor to exercise the voting and other consensual rights which it
        would otherwise be entitled to exercise pursuant to Section (a) of
        Article VII above, and to receive the dividends and distributions which
        it would otherwise be authorized to receive and retain pursuant to
        Section (b) of Article VIII above, shall cease, and all such rights
        thereupon shall become vested in the Noteholders which thereupon shall
        have the sole right to exercise such voting and other consensual rights
        and to receive and to hold as pledged Investment Collateral such
        dividends and distributions.

                (b)     all dividends and other distributions which are received
        by a Grantor contrary to the provisions of this Agreement shall be held
        in trust for the benefit of the Noteholders, shall be segregated from
        other funds of the Grantor and forthwith shall be paid over to the
        Noteholders as pledged Collateral in the same form as so received (with
        any necessary endorsements).

<PAGE>

         ARTICLE IX - GENERAL REPRESENTATIONS, WARRANTIES AND COVENANTS

        9.1     The Grantor represents, warrants and covenants, which
representations, warranties and covenants shall survive execution and delivery
of this Agreement, as follows:

                (a)     except for the interest granted to the Noteholders
        herein, rights disclosed in Section 2.5 and as disclosed on SCHEDULE
        9.1, the Grantor is, and as to Collateral acquired from time to time
        after the date hereof, the Grantor will be, the owner of all the
        Collateral free from any lien, security interest, encumbrance or other
        right, title or interest of any person, and the Grantor shall defend the
        Collateral against all claims and demands of all persons at any time
        claiming the same or any interest therein adverse to the Noteholders.

                (b)     except as disclosed on SCHEDULE 9.1, there is no
        financing statement (or similar statement or instrument of registration
        under the law of any jurisdiction) now on file or registered in any
        public office covering any interest of any kind in the Collateral, or
        intended to cover any such interest, which has not been terminated or
        released by the secured party named therein, and so long as any Notes
        remain outstanding or any of the Secured Obligations of the Grantor
        remain unpaid, the Grantor will not execute and there will not be on
        file in any public office any financing statement (or similar statement
        or instrument of registration under the law of any jurisdiction) or
        statements relating to the Collateral, except financing statements filed
        or to be filed in respect of and covering the security interest hereby
        granted to the Noteholders.

                (c)     at the Grantor's own expense, the Grantor will keep the
        Collateral (i) in good condition at all times (normal wear and tear
        excepted) and maintain same in accordance with all manufacturer's
        specifications and requirements, and (ii) free and clear of all liens
        and encumbrances, except for the liens granted or permitted hereby; and
        without the consent of the Noteholders, the Grantor will not sell,
        transfer, change the registration, if any, dispose of, attempt to
        dispose of, substantially modify or abandon the Collateral or any part
        thereof other than sales of inventory in the ordinary course of business
        and the disposition of obsolete or worn-out equipment in the ordinary
        course of business.

                (d)     the chief executive office and chief place of business
        of Vyteris is located at 13-01 Pollitt Drive, Fairlawn, New Jersey
        07410. The Grantor will not move its chief executive office and chief
        place of business until (i) it shall have given to the Noteholders not
        less than 30 days' prior written notice of its intention to do so,
        clearly describing such new location and providing such other
        information in connection therewith as the Noteholders may reasonably
        request, and (ii) with respect to such new location, it shall have taken
        such action, satisfactory to the Noteholders, to maintain the security
        interest of the Noteholders, in the Collateral.

<PAGE>

                         ARTICLE X - COSTS AND EXPENSES

                10.1    The Grantor agrees to pay to the Noteholders all costs
and expenses (including, without limitation, reasonable attorneys' fees and
disbursements) incurred by the Noteholders in the enforcement or attempted
enforcement of this Agreement, whether or not an action is filed in connection
therewith, and in connection with any waiver or amendment of any term or
provision hereof. All advances, charges, costs and expenses, including
reasonable attorneys' fees and disbursements, incurred or paid by the
Noteholders in exercising any right, privilege, power or remedy conferred by
this Agreement or in the enforcement or attempted enforcement thereof, shall be
secured hereby and shall become a part of the Secured Obligations and shall be
paid to the Noteholders by the Grantor, immediately upon demand, together with
interest thereon from the date of demand at a rate of 8% per annum.

                         ARTICLE XI - CONTINUING EFFECT

                11.1    This Agreement shall remain in full force and effect and
continue to be effective should any petition be filed by or against the Grantor
for liquidation or reorganization, should the Grantor become insolvent or make
an assignment for the benefit of creditors or should a receiver or trustee be
appointed for all or any significant part of the Grantor's assets, and shall
continue to be effective or be reinstated, as the case may be, if at any time
payment and performance of the Secured Obligations, or any part thereof, is,
pursuant to applicable law, rescinded or reduced in amount, or must otherwise be
restored or returned by the Noteholders, whether as a "voidable preference,"
"fraudulent conveyance" or otherwise, all as though such payment or performance
had not been made. In the event that any payment or any part thereof is
rescinded, reduced, restored or returned, the Secured Obligations shall be
reinstated and deemed reduced only by such amount paid and not so rescinded,
reduced, restored or returned.

                ARTICLE XII - TERMINATION; RELEASE OF THE GRANTOR

                12.1    This Agreement shall be terminated and all Secured
Obligations of the Grantor hereunder shall be released when all Secured
Obligations of the Grantor have been paid in full or upon such release of the
Grantor's Secured Obligations hereunder or, with respect to any Note, when such
Note shall no longer be outstanding. Upon such termination, the Noteholders
shall return any pledged Collateral to the Grantor, or to the person or persons
legally entitled thereto, and shall endorse, execute, deliver, record and file
all instruments and documents, and do all other acts and things reasonably
required for the return of the Collateral to the Grantor, or to the person or
persons legally entitled thereto, and to evidence or document the release of the
Noteholders' interests arising under this Agreement, all as reasonably requested
by, and at the sole expense of, the Grantor.

<PAGE>

                          ARTICLE XIII - GOVERNING LAW

                13.1    THIS AGREEMENT SHALL BE CONSTRUED AND ENFORCED IN
ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF DELAWARE.

                            ARTICLE XIV - ASSIGNMENT

                14.1    This Agreement shall create a continuing security
interest in the Collateral and shall be binding upon the Grantor and the
Grantor's successors and assigns; inure, together with the rights and remedies
of the Noteholders and their successors, transferees and assigns; and be
severable in the event that one or more of the provisions herein is determined
to be illegal or unenforceable. Without limiting the generality of the
foregoing, the Noteholders may assign or otherwise transfer any portion of the
Secured Obligations to any other person or entity, and such other person or
entity shall thereupon become vested with all the benefits and obligations in
respect thereof granted to the Noteholders herein or otherwise.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

        IN WITNESS WHEREOF, the undersigned have executed this Agreement by its
duly authorized officer as of the date first written above.

                                         VYTERIS, INC.

                                         By:
                                             ---------------------
                                             Name: Vincent De Caprio
                                             Title: President

                                         SPENCER TRASK SPECIALTY GROUP, LLC

                                         By:
                                             ---------------------
                                             Name: Donald F. Farley
                                             Title: Chief Executive Officer

                                         NOTEHOLDERS:

                                         SEE OMNIBUS SIGNATURE PAGE TO THE SPA

<PAGE>

                                    EXHIBIT F

                            FORM OF WARRANT AGREEMENT

<PAGE>

                                WARRANT AGREEMENT

        This WARRANT AGREEMENT (this "Agreement") dated as of _________ __, 200_
is made by and between Vyteris, Inc., a Delaware corporation ("Vyteris," the
"Grantor" or the "Company") and the purchasers of certain five-year warrants
(the "Holders") to purchase common stock, $0.0001 par value per share, of the
Company ("Common Stock") who are parities to that certain Securities Purchase
Agreement, dated September 29, 2004 (the "SPA").

                               W I T N E S S E T H

        WHEREAS, pursuant to its execution of a Signature Financing Page in the
form attached to the SPA as EXHIBIT B, each such subscriber has become a Holder,
and has agreed to be subject to the terms of this Agreement; and

        WHEREAS, each time a Holder loans funds to the Company in accordance
with the terms of the SPA, the Company shall issue to such Holder a warrant
(each, a "Warrant," and collectively, the "Warrants"), in substantially the form
attached hereto as EXHIBIT A, pursuant to the terms of this Agreement Warrant,
to purchase up to such number of shares of Common Stock (the "Warrant Shares")
equal to the quotient obtained by dividing (i) 40% of the amount loaned by such
Holder on such date, by (ii) 1.50.

        NOW, THEREFORE, in consideration of the promises, the agreements herein
set forth and other good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, the parties hereto agree as follows:

        1.      GRANT. Subject to the terms and conditions hereinafter set
forth, the Holders are hereby granted the right to purchase Warrant Shares,
subject to the terms and conditions of this Agreement.

        2.      WARRANT CERTIFICATES. The Warrant certificates (the "Warrant
Certificates") delivered and to be delivered pursuant to this Agreement shall be
in the form set forth in EXHIBIT A attached hereto and made a part hereof, with
such appropriate insertions, omissions, substitutions, and other variations as
required or permitted by this Agreement.

        3.      EXERCISE OF THE WARRANTS.

        3.1     METHOD OF EXERCISE. The Warrants are initially exercisable for
Warrant Shares at the Exercise Price (as defined in Section 5.2 hereof), subject
to adjustment as provided in Section 7 hereof, payable by certified or official
bank check or cash. Upon surrender of a Warrant Certificate with the annexed
Form of Election to Purchase duly executed, together with payment of the
Exercise Price for the Warrant Shares at the Company's principal offices,
currently at 13-01 Pollitt Drive, Fair Lawn, New Jersey 07410, the registered
holder of a Warrant Certificate ("Holder" or "Holders") shall be entitled to
receive a certificate or certificates for the Warrant Shares so purchased. The
purchase rights represented by each Warrant Certificate are exercisable at the
option of the Holder(s) thereof, in whole or in part (but not as to fractional

<PAGE>

shares of the Warrant Shares). The Warrants may be exercised to purchase all or
part of the Warrant Shares represented thereby. In the case of purchase of less
than all the Warrant Shares purchasable under any Warrant Certificate, the
Company shall cancel such Warrant Certificate upon the surrender thereof and
shall execute and deliver a new Warrant Certificate of like tenor for the
balance of the Warrant Shares.

        3.2     NET EXERCISE BY SURRENDER OF THE WARRANTS. In addition to the
method of payment set forth in Section 3.1 and in lieu of any cash payment
required thereunder, the Holder(s) of the Warrants shall have the right at any
time and from time to time to exercise the Warrants in full or in part by
surrendering a Warrant Certificate in the manner specified in Section 3.1 in
exchange for the number of Warrant Shares computed by using the following
formula:

                     X = Y (A - B)
                         ---------
                             A

        Where  X  =  the number of Warrant Shares to be issued to the Holder(s)
                     pursuant to the net exercise.

               Y  =  the number of Warrant Shares subject to the Warrant being
                     exercised or, if only a portion of such Warrant is being
                     exercised, the portion of such Warrant being canceled (at
                     the time of such calculation).

               A  =  the Fair Market Value of one share of Common Stock (at the
                     date of exercise).

               B  =  the Exercise Price (as adjusted to the date of such
                     calculation).

        For purposes of this Section 3.2, the "Fair Market Value" of one share
of Common Stock shall equal: (i) the average of the closing sale price of the
Common Stock (or any other security for which the Warrants are then exercisable)
as quoted on the Nasdaq Stock Market or in the Over-The-Counter Market or the
closing price quoted on any national securities exchange on which such
securities are listed, whichever is applicable, for the five trading days
immediately prior to the date of exercise or, (ii) if no sales take place on any
such trading day, the average of the closing bid and asked prices on such
trading day; or (iii) if the Common Stock (or any other security for which the
Warrants are then exercisable) is not quoted on the Nasdaq Stock Market or
Over-The-Counter or on a national securities exchange, the Fair Market Value of
the Common Stock shall be established in good faith by the disinterested members
of the Company's Board of Directors.

        3.3.    EXERCISE PERIOD. The shall be exercisable, in whole or in part,
during the term commencing on the Warrant Issue Date and ending on the date five
(5) years after the Warrant Issue Date (the "Expiration Time").

<PAGE>

        4.      ISSUANCE OF CERTIFICATES.

        4.1     In the event of any exercise of the rights represented by the
Warrants, as promptly as practicable on or after the date of exercise and in any
event within ten (10) business days thereafter, the Company at its expense shall
issue and deliver to the Person or Persons (as hereinafter defined) entitled to
receive the same a certificate or certificates representing the number of
Warrant Shares issued upon such exercise. In the event that the Warrants are
exercised in part, as promptly as practicable on or after the date of exercise
and in any event within ten (10) business days thereafter, the Company at its
sole expense will execute and deliver new Warrants Certificates of like tenor
exercisable for the number of Warrant Shares for which the Warrants may then be
exercised. As used herein, the term "Person" or "Persons" means any individual
or any corporation, partnership, trust, limited liability company or other
entity or organization of any kind.

        4.2     The issuance of the Warrant Shares upon the exercise of the
Warrants, and the delivery of certificates or other instruments representing
such Warrant Shares, shall be made without charge to the Holder(s) for any tax
or other charge of whatever nature in respect of such issuance and the Company
shall bear any such taxes in respect of such issuance.

        5.      EXERCISE PRICE.

        5.1     INITIAL AND ADJUSTED EXERCISE PRICE. Except as otherwise
provided in Section 7 hereof, the Warrants shall be exercisable to purchase
Warrant Shares at an initial price of $1.50 per share. The adjusted exercise
price shall be the price that shall result from time to time from any and all
adjustments of the initial Exercise Price in accordance with the provisions of
Section 7 hereof.

        5.2     EXERCISE PRICE. The term "Exercise Price" herein shall mean the
initial exercise price or the adjusted exercise price, depending upon the
context.

        6.      TRANSFER OF SECURITIES

        6.1     LEGENDS. Each Holder, by acceptance of a Warrant Certificate,
covenants and agrees that it is acquiring the Warrants evidenced thereby and the
Warrant Shares for its own account as an investment and not with a view to the
distribution thereof. The Warrants and Warrant Shares have not been registered
under the Securities Act of 1933 (the "Act"), or any state securities laws and
no transfer of any Warrant or Warrant Shares shall be permitted unless the
Company has received notice of such transfer, at the address of its principal
office set forth in Section 3.1 hereof, in the form of assignment attached
hereto, accompanied by an opinion of counsel reasonably satisfactory to the
Company that an exemption from registration of such Warrant or Warrant Shares
under the Act is available for such transfer.

                THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT
                BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
                AMENDED (THE "ACT"), OR THE SECURITIES LAWS OF ANY
                STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT
                PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER
                SUCH ACT AND APPLICABLE STATE SECURITIES LAWS OR
                PURSUANT TO AN OPINION OF COUNSEL REASONABLY
                SATISFACTORY TO THE ISSUER THAT APPLICABLE EXEMPTION
                FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH
                LAWS IS AVAILABLE.

<PAGE>

                THE TRANSFER, EXCHANGE AND EXERCISE OF THE WARRANTS
                REPRESENTED BY THIS CERTIFICATE ARE RESTRICTED IN
                ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO
                HEREIN.

        6.2     REMOVAL OF LEGEND. Upon request of a Holder of a certificate
with the legends required by Section 6.1 hereof, the Company shall issue to such
Holder a new certificate therefor free of any transfer legend, if, with such
request, the Company shall have received an opinion of counsel satisfactory to
the Company in form and substance to the effect that any transfer by such Holder
of the shares evidenced by such certificate will not violate the Act and any
applicable state securities laws. Any purported transfer of any Warrant or
Warrant Shares not in compliance with the provisions of this Section 6 shall be
null and void.

        7.      ADJUSTMENT OF EXERCISE PRICE AND NUMBER OF WARRANT SHARES. The
number of Warrant Shares purchasable upon the exercise of the Warrants (in the
case of paragraphs (a) and (c) below) and the Exercise Price therefore (in the
case of paragraphs (a), (b) and (c) below) shall be subject to adjustment from
time to time upon the occurrence of certain events, as follows:

                (a)     ADJUSTMENT FOR RECLASSIFICATION, CONSOLIDATION OR
MERGER. If while any Warrant, or any portion thereof, remains outstanding and
unexpired there shall be (i) a reorganization or recapitalization (other than a
combination, reclassification, exchange or subdivision of shares otherwise
provided for herein), (ii) a merger or consolidation of the Company with or into
another Person in which the Company is not the surviving entity, or a reverse
merger in which the Company is the surviving entity but the shares of the
Company's capital stock outstanding immediately prior to the merger are
converted by virtue of the merger into other property, whether in the form of
securities, cash, or otherwise, or (iii) a sale or transfer of the Company's
properties and assets as, or substantially as, an entirety to any other Person
in one transaction or a series of related transactions, then, as a part of such
reorganization, recapitalization, merger, consolidation, sale or transfer,
unless otherwise directed by the Holder(s), all necessary or appropriate lawful
provisions shall be made so that the Holder(s) shall thereafter be entitled to
receive upon exercise of its Warrant, during the period specified herein and
upon payment of the Exercise Price then in effect, the greatest number of shares
of stock or other securities or property that a holder of Warrant Shares
deliverable upon exercise of such Warrant would have been entitled to receive in
such reorganization, recapitalization, consolidation, merger, sale or transfer
if such Warrants had been exercised immediately prior to such reorganization,
recapitalization, merger, consolidation, sale or transfer, all subject to
further adjustment as provided in this Section 7. If the per share consideration
payable to the Holder(s)

<PAGE>

for Warrant Shares in connection with any such transaction is in a form other
than cash or marketable securities, then the value of such consideration shall
be determined in good faith by the Company's Board of Directors. The foregoing
provisions of this paragraph shall similarly apply to successive
reorganizations, recapitalizations, consolidations, mergers, sales and transfers
and to the stock or securities of any other corporation that are at the time
receivable upon the exercise of such Warrant. In all events, appropriate
adjustment shall be made in the application of the provisions of the Warrants
(including adjustment of the Exercise Price and number of Warrant Shares
purchasable pursuant to the terms and conditions of the Warrants) with respect
to the rights and interests of the Holder(s) after the transaction, to the end
that the provisions of each Warrant shall be applicable after that event, as
near as reasonably may be, in relation to any shares or other property
deliverable or issuable after such reorganization, recapitalization, merger,
consolidation, sale or transfer upon exercise of each Warrant.

                (b)     ADJUSTMENTS FOR SPLIT, SUBDIVISION OR COMBINATION OF
WARRANT SHARES. If the Company at any time while the Warrants, or any portion
thereof, remain outstanding and unexpired shall split or subdivide any class of
securities as to which purchase rights under the Warrants exist, into a
different number of securities of the same class, the number of shares of such
class issuable upon exercise of the Warrants immediately prior to such split or
subdivision shall be proportionately adjusted and the Exercise Price for such
class of securities shall be proportionately adjusted. If the Company at any
time while the Warrants, or any portion thereof, remain outstanding and
unexpired shall combine any class of securities as to which purchase rights
under this Agreement exist, into a different number of securities of the same
class, the number of shares of such class issuable upon exercise of The Warrants
immediately prior to such combination shall be proportionately adjusted and the
Exercise Price for such class of securities shall be proportionately adjusted.

                (c)     ADJUSTMENTS FOR DIVIDENDS IN STOCK OR OTHER SECURITIES
OR PROPERTY. If while the Warrants, or any portion thereof, remain outstanding
and unexpired, the Holders shall have received, or, on or after the record date
fixed for the determination of eligible stockholders, shall have become entitled
to receive, without payment therefore, other or additional stock or other
securities or property (other than cash) of the Company by way of dividend, then
and in each case, the Warrants shall represent the right to acquire, in addition
to the number of shares of such class of security receivable upon exercise of
the Warrants, and without payment of any additional consideration therefore, the
amount of such other or additional stock or other securities or property (other
than cash) of the Company that such holder would hold on the date of such
exercise had it been the holder of record of the class of security receivable
upon exercise of the Warrants on the date hereof and had thereafter, during the
period from the date hereof to and including the date of such exercise, retained
such shares and/or all other additional stock available by it as aforesaid
during said period, giving effect to all adjustments called for during such
period by the provisions of this Section 7.

                (d)     ADJUSTMENT OF EXERCISE PRICE UPON ISSUANCE OF ADDITIONAL
SHARES OF COMMON STOCK. If while the Warrants, or any portion thereof, remain
outstanding and unexpired, the Company shall issue Additional Shares of Common
Stock (as hereinafter defined) without consideration or for a consideration per
share less than the then-applicable Exercise Price, then

<PAGE>

and in such event, such Exercise Price shall be reduced, concurrently with such
issue, to a price (rounded up to the nearest cent) determined by multiplying the
then-applicable Exercise Price by a fraction, (i) the numerator of which shall
be the number of shares of the Company's Common Stock issued and outstanding (on
an as-converted, fully-diluted basis) immediately prior to such issuance plus
the quotient obtained by dividing (x) the aggregate consideration received by
the Company for the total number of Additional Shares of Common Stock so issued
by (y) the Exercise Price, and (ii) the denominator of which shall be the number
of shares of the Common Stock issued and outstanding (on a fully-diluted basis)
immediately prior to such issuance plus the number of Additional Shares of
Common Stock so issued. Upon each such adjustment of the then-applicable
Exercise Price pursuant to the provisions of this Section 7, the number of
Warrant Shares purchasable upon the exercise of the Warrants shall be adjusted
to the nearest full amount by multiplying a number equal to the Exercise Price
in effect immediately prior to such adjustment by the number of Warrant Shares
purchasable upon the exercise of the Warrants immediately prior to such
adjustment and dividing the product so obtained by the adjusted Exercise Price.

        For the purposes hereof "Additional Shares of Common Stock" shall mean
all shares of Common Stock, or options, rights, warrants to subscribe for common
stock, or securities convertible into or exchangeable for shares of common
stock, actually issued by the Company on or after the date hereof, other than
shares of common stock issued at any time:

                (i)     upon exercise of the Warrants;

                (ii)    pursuant to the exercise of options, warrants or other
common stock purchase rights issued (or to be issued) to employees, officers or
directors of, or consultants or advisors to, or any strategic ally of, the
Company pursuant to any stock purchase or stock option plan or other arrangement
approved by the Board of Directors;

                (iii)   pursuant to the exercise of options, warrants or any
evidence of indebtedness, shares of capital stock (other than common stock) or
other securities convertible into or exchangeable for the Company's common
stock; or

                (iv)    in connection with the acquisition of all or part of
another entity by stock acquisition, merger, consolidation or other
reorganization, or by the purchase of all or part of the assets of such other
entity (including securities issued to persons formerly employed by such other
entity and subsequently hired by the Company and to any brokers or finders in
connection therewith) where the Company or its stockholders own more than fifty
(50%) percent of the voting power of the acquired, surviving, combined or
successor company.

                (e)     NOTICE OF ADJUSTMENTS. Upon any adjustment of the
Exercise Price and any increase or decrease in the number of Warrant Shares
purchasable upon the exercise of the Warrants, then, and in each such case, the
Company, within 30 days thereafter, shall give written notice thereof to the
Holder(s) at the address of such Holder(s) as shown on the books of the Company
which notice shall state the Exercise Price as adjusted and, if applicable, the

<PAGE>

increased or decreased number of Warrant Shares purchasable upon the exercise of
the Warrants, setting forth in reasonable detail the method of calculation of
each.

        8.      REGISTRATION RIGHTS.

        8.1     PIGGYBACK REGISTRATION. If, at any time commencing after the
date hereof until the Expiration Time, the Company proposes to register any of
its securities under the Securities Act of 1933, as amended (the "Act"), (other
than in connection with a merger, pursuant to Form S-8, S-4 or comparable
registration statement) it will give written notice by registered mail, at least
thirty (30) business days prior to the filing of each such registration
statement, to the registered Holder of the Warrant Shares of its intention to do
so. If the Holder of the Warrant Shares notifies the Company within twenty (20)
days after receipt of any such notice of its desire to include any Warrant
Shares in such proposed registration statement, the Company shall afford the
Holder of the Warrant Shares the opportunity to have any such Warrant Shares
registered under such registration statement.

        Notwithstanding the provisions of this Section 8.1, (A) the Company
shall have the right any time after it shall have given written notice pursuant
to this Section 8.1 (irrespective of whether a written request for inclusion of
any such securities shall have been made) to elect to postpone or not to file
any such proposed registration statement, or to withdraw the same after filing
but prior to the effective date thereof and (B) if the underwriter or
underwriters, if any, of any such proposed public offering shall be of the
reasonable opinion that the total amount or kind of securities held by the
Holders of Warrant Shares and any other persons or entities entitled to be
included in such public offering would adversely affect the success of such
public offering, then the amount of securities to be offered for the accounts of
Holders of Warrant Shares shall be reduced pro rata to the extent necessary to
reduce the total amount of securities to be included in such public offering to
the amount reasonably recommended by the underwriter or underwriters thereof,
whereupon the Company shall only be obligated to register such limited portion
(which may be none) of the Warrant Shares with respect to which such holder has
provided notice pursuant to this Section 8.1. In no event shall the Company be
required pursuant to this Section 8.1 to reduce the amount of securities to be
registered by it.

        8.2.    COVENANTS OF THE COMPANY WITH RESPECT TO REGISTRATION. In
connection with any registration under the previous paragraph, the Company
covenants and agrees as follows: (i) the Company shall use its best efforts to
file a registration statement as soon as practicable and shall use its best
efforts to have any registration statement declared effective at the earliest
possible time, and shall furnish Holder desiring to sell the Warrant Shares such
number of prospectuses as shall reasonably be requested; (ii) the Company shall
pay all costs (excluding fees and expenses of Holder's counsel and any
underwriting or selling commissions or other charges of any broker-dealer acting
on behalf of such Holder), fees and expenses in connection with all registration
statements filed pursuant to the previous paragraph including, without
limitation, the Company's legal and accounting fees, printing expenses, blue sky
fees and expenses; (iii) the Company shall take all necessary action which may
be required in qualifying or registering the Warrant Shares included in the
registration statement for offering and sale under the securities or blue sky
laws of such states as reasonably are requested by the Holder, provided that the
Company shall not be

<PAGE>

obligated to execute or file any general consent to service of process or to
qualify as a foreign corporation to do business under the laws of any such
jurisdiction; (iv) the Company shall indemnify the Holder of the Warrant Shares
to be sold pursuant to any registration statement and each person, if any, who
controls such Holder within the meaning of Section 15 of the Act or Section
20(a) of the Exchange Act of 1934, as amended (the "Exchange Act"), against all
loss, claim, damage, expense or liability (including all expenses reasonably
incurred in investigating, preparing or defending against any claim whatsoever)
to which any of them may become subject which relate to any registration
statement(s) prepared in connection herewith; (v) the Holder of the Warrant
Shares to be sold pursuant to a registration statement, and their successors and
assigns, shall severally and not jointly indemnify the Company, its officers and
directors and each person, if any, who controls the Company within the meaning
of Section 15 of the Act or Section 20(a) of the Exchange Act, against all loss,
claim, damage or expense or liability (including all expenses reasonably
incurred in investigating, preparing or defending against any claim whatsoever)
to which they may become subject under the Act, the Exchange Act or otherwise,
arising from any information furnished by or on behalf of such Holder, or their
successors or assigns, for specific inclusion in such a registration statement;
(vi) nothing contained in this Warrant shall be construed as requiring the
Holder to exercise this Warrant prior to the initial filing of any registration
statement or the effectiveness thereof; (vii) the Company shall prepare and file
with the Securities and Exchange Commission (the "Commission") such amendments,
post-effective amendments and supplements to the registration statement and the
prospectus included therein as may be necessary to keep the registration
statement effective until the later of (i) the date when all Warrant Shares
registered have been sold or (ii) until such time as the Warrant Shares are free
of restriction on resale under the Act (by removal of all restrictive legends,
instructions to transfer or otherwise) pursuant to Rule 144; and comply with the
provisions of the Act with respect to the disposition of all securities covered
by such registration statement during the applicable period in accordance with
the intended method or methods of distribution by the sellers thereof as set
forth in such registration statement or supplement of the prospectus; (viii) the
Company shall furnish to the Holder participating in an offering including
Warrant Shares and to each underwriter, if any, a signed counterpart, addressed
to the Holder or underwriter, of (A) an opinion of counsel to the Company, dated
the effective date of such registration statement (and, if such registration
includes an underwritten public offering, an opinion dated the date of the
closing under the underwriting agreement), and (B) a "cold comfort" letter dated
the effective date of such registration statement (and, if such registration
includes an underwritten public offering, a letter dated the date of the closing
under the underwriting agreement) signed by the independent public accountants
who have issued a report on the Company's financial statements included in such
registration statement, in each case covering substantially the same matters
with respect to such registration statement (and the prospectus included
therein) and, in the case of such accountants' letter, with respect to events
subsequent to the date of such financial statements, as are customarily covered
in opinions of issuer's counsel and in accountants' letters delivered to
underwriters in underwritten public offerings of securities; (vii) the Company
shall, as soon as practicable after the effective date of a registration
statement relating to any Warrant Shares pursuant to the previous paragraph, and
in any event within fifteen (15) months thereafter, use its reasonable efforts
to make "generally available to its security holders" (within the meaning of
Rule 158 under the Act) an earnings statement (which need not be audited)
complying with

<PAGE>

Section 11(a) of the Act and covering a period of at least (12) consecutive
months beginning after the effective date of the registration statement; and
(viii) upon the written request of the Holder, the Company shall deliver
promptly to the Holder participating in an offering including any Warrant Shares
pursuant to the previous paragraph who so requests and to the managing
underwriter, copies of all correspondence between the Commission and the
Company, its counsel or auditors and all memoranda relating to discussions with
the Commission or its staff with respect to the registration statement and shall
permit the Holder and underwriter to do such investigation, upon reasonable
advance notice, with respect to information contained in or omitted from the
registration statement as it deems reasonably necessary to comply with
applicable securities laws or rules of the National Association of Securities
Dealers, Inc. ("NASD"). Such investigation shall include access to books,
records and properties and opportunities to discuss the business of the Company
with its officers and independent auditors, all to such reasonable extent and at
such reasonable times and as often as any such Holder shall reasonably request
as it deems necessary to comply with applicable securities laws and NASD rules.

        9.      EXCHANGE AND REPLACEMENT OF WARRANT CERTIFICATES. Each Warrant
Certificate is exchangeable without expense, upon the surrender thereof by the
registered Holder(s) at the principal office of the Company, for a new Warrant
Certificate of like form, tenor and date representing in the aggregate the right
to purchase the same number of securities in such denominations as shall be
designated by the Holder(s) thereof at the time of such surrender.

        Upon receipt by the Company of evidence reasonably satisfactory to it of
the loss, theft, destruction or mutilation of any Warrant Certificate, and, in
case of loss, theft or destruction, of indemnity or security reasonably
satisfactory to it, and reimbursement to the Company of all reasonable expenses
incidental thereto, and upon surrender and cancellation of the Warrants, if
mutilated, the Company will make and deliver a new Warrant Certificate of like
form and tenor in lieu thereof.

        10.     FRACTIONAL SHARES. No fractional shares will be issued in
connection with any exercise hereunder. Instead, the Company shall pay to
Holder(s) an amount in cash equal to any fractional share to which the Holder(s)
would be entitled, multiplied by the Fair Market Value of the Common Stock.

        11.     STOCK FULLY PAID; RESERVATION OF SHARES. The Company shall at
all times reserve and keep available out of its authorized Common Stock, solely
for the purpose of issuance upon the exercise of the Warrants, such number of
Warrant Shares into which Warrants are exercisable. The Company covenants and
agrees that, upon exercise of the Warrants and payment of the Exercise Price
therefore, all shares of Common Stock shall be duly and validly issued, fully
paid, non-assessable and not subject to the preemptive rights of any
stockholder.

        12.     RIGHTS OF STOCKHOLDERS. Except as expressly provided in Section
3 hereof, no Holder, as such, shall be entitled to vote or receive dividends or
be deemed the holder of the Warrant Shares or any other securities of the
Company that may at any time be issuable on the exercise hereof for any purpose,
nor shall anything contained herein be construed to confer upon

<PAGE>

the Holder(s), as such, any of the rights of a stockholder of the Company or any
right to vote for the election of directors or upon any matter submitted to
stockholders at any meeting thereof, or to give or withhold consent to any
corporate action (whether upon any recapitalization, issuance of stock,
reclassification of stock, change of par value, consolidation, merger,
conveyance, or otherwise) or to receive notice of meetings, or to receive
dividends or subscription rights or otherwise until the Warrants shall have been
exercised and the Warrant Shares purchasable upon the exercise thereof shall
have been issued, as provided herein.

        13.     NOTICES. All notices, requests, consents and other
communications hereunder shall be in writing and shall be deemed to have been
duly made when delivered, or mailed by registered or certified mail, return
receipt requested:

        13.1    If to a registered Holder(s) of the Warrants, to the address of
such Holder(s) as shown on the books of the Company; or

        13.2    If to the Company, at 13-01 Pollitt Drive, Fair Lawn, New Jersey
07410, Attention: Vincent L. DeCaprio Ph.D., President, or Michael McGuinness,
Chief Financial Officer, or at such other address as may have been furnished in
writing by the Company, with a copy to Lowenstein Sandler PC, 65 Livingston
Avenue, Roseland, New Jersey 07068, Attention: Peter H. Ehrenberg, Esq.; or

        14.     SUPPLEMENTS AND AMENDMENTS. The Company may from time to time
supplement or amend this Agreement without the approval of any Holder(s) in
order to cure any ambiguity, to correct or supplement any provision contained
herein which may be defective or inconsistent with any provision herein, or to
make any other provisions in regard to matters or questions arising hereunder
which the Company may deem necessary or desirable and which the Company deems
shall not adversely affect the interests of the Company and/or the Holder(s).
Other amendments to this Agreement may be made only with the written consent of
the Company and the Holder(s) of the majority of the outstanding Warrant Shares
issuable upon exercise of the Warrants.

        15.     SUCCESSORS. All the covenants and provisions of this Agreement
shall be binding upon and inure to the benefit of the Company, the Holder(s) and
their respective successors and assigns hereunder.

        16.     TERMINATION. This Agreement shall terminate at the close of
business on the expiration time.

        17.     GOVERNING LAW. This Agreement shall be governed by and
construed, interpreted and enforced in accordance with the law of the State of
Delaware and the federal law of the United States without regard to the law of
any other jurisdiction.

        18.     WAIVER OF TRIAL BY JURY AND CLAIMS TO CERTAIN DAMAGES. THE
BORROWER KNOWINGLY, VOLUNTARILY, INTENTIONALLY AND IRREVOCABLY WAIVES EACH RIGHT
THE BORROWER MAY HAVE TO A

<PAGE>

TRIAL BY JURY WITH RESPECT TO, AND EACH RIGHT TO ASSERT ANY CLAIM FOR DAMAGES
(INCLUDING, BUT NOT LIMITED TO, PUNITIVE DAMAGES) IN ADDITION TO ACTUAL DAMAGES
IN, ANY ACTION OR OTHER LEGAL PROCEEDING, WHETHER BASED ON ANY CONTRACT OR
NEGLIGENT, INTENTIONAL OR OTHER TORT OR OTHERWISE, ARISING OUT OF OR OTHERWISE
RELATING TO (A) THE CREDIT, ANY LOAN OR COLLATERAL, THIS NOTE OR ANY OTHER
WRITING HERETOFORE OR HEREAFTER EXECUTED IN CONNECTION WITH THE CREDIT OR ANY
LOAN OR COLLATERAL, (B) ANY TRANSACTION ARISING OUT OF OR OTHERWISE RELATING TO
THE CREDIT, ANY LOAN OR COLLATERAL, THIS NOTE OR ANY SUCH OTHER WRITING OR (C)
ANY NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT OF THE CREDIT, ANY
LOAN OR COLLATERAL, THIS NOTE OR ANY SUCH OTHER WRITING.

        19.     ENTIRE AGREEMENT; MODIFICATION. This Agreement contains the
entire understanding between the parties hereto with respect to the subject
matter hereof and may not be modified or amended except as provided in Section
13 hereof.

        20.     SEVERABILITY. If any provision of this Agreement shall be held
to be invalid and unenforceable, such invalidity or unenforceability shall not
affect any other provision of this Agreement.

        21.     CAPTIONS. The caption headings of the Sections of this Agreement
are for convenience of reference only and are not intended, nor should they be
construed, as a part of this Agreement and shall be given no substantive effect.

        22.     BENEFITS OF THIS AGREEMENT. Nothing in this Agreement shall be
construed to give to any person, entity or corporation other than the Company
and any registered Holder(s) of the Warrant Certificates, Warrant Shares any
legal or equitable right, remedy or claim under this Agreement; and this
Agreement shall be for the sole and exclusive benefit of the Company and the
Holder(s) of the Warrant Certificates or Warrant Shares.

        23.     COUNTERPARTS. This Agreement may be executed in any number of
counterparts and each of such counterpart shall for all purposes be deemed to be
an original, and such counterparts shall together constitute but one and the
same instrument.

        24.     ASSIGNMENT. Any Person or Persons to whom the Warrants are
transferred by a Holder shall agree to be bound by all of the provisions hereof;
and the transferring Holder shall not transfer any Warrants unless the
transferring Holder first provides a written instrument to the Company notifying
the Company of such transfer pursuant to which the transferee agrees in writing
to be bound by the terms of this Agreement.

<PAGE>

        IN WITNESS WHEREOF, the parties hereto have caused this Warrant
Agreement to be duly executed as of the day and year first above written.

                                       VYTERIS, INC.

                                       By:  _________________________________
                                            Name: Vincent L. DeCaprio, Ph.D.
                                            Title: President

Attest:

-------------------------
Secretary

                                            HOLDERS:

                                            SEE OMNIBUS SIGNATURE PAGE TO SPA

<PAGE>

                                    EXHIBIT A

                          [FORM OF WARRANT CERTIFICATE]

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR THE SECURITIES LAWS OF
ANY STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT PURSUANT TO (i) AN
EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES
LAWS OR (ii) AN OPINION OF COUNSEL, REASONABLY SATISFACTORY TO THE ISSER, THAT
AN APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH
LAWS IS AVAILABLE.

THE TRANSFER, EXCHANGE AND EXERCISE OF THE WARRANTS REPRESENTED BY THIS
CERTIFICATE ARE RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO
HEREIN.

No. St-__
_______Warrants
                                                          _____________ __, 200_

                               WARRANT CERTIFICATE

        This Warrant Certificate certifies that _________________________, or
its registered assigns, is the registered holder of ____________________warrants
(the "Warrants") to purchase initially, at any time after the date hereof
("Warrant Issue Date") until 5:30 p.m. New York time on September __, 2009 (the
"Expiration Date"), up to ___________ fully paid and non-assessable shares of
Common Stock, $0.0001 par value per share ("Common Stock") of the Company, at
the initial exercise price, subject to adjustment in certain events (the
"Exercise Price"), of $1.50 upon surrender of this Warrant Certificate and
payment of the Exercise Price at an office or agency of the Company, or by
surrender of this Warrant Certificate in lieu of cash payment, but subject to
the conditions and adjustments set forth in the Warrant Agreement dated as of
___________ ___, 200_ entered into by and among the Company and each holder of
Warrants (the "Warrant Agreement"). Except as otherwise provided in Section 3.2
of the Warrant Agreement, payment of the Exercise Price shall be made by
certified or official bank check in New York Clearing House funds payable to the
order of the Company.

        No Warrant may be exercised after 5:30 p.m. (New York time) on the
Expiration Date, at which time the Warrants evidenced hereby, unless exercised
prior thereto, shall thereafter be void.

        The Warrants evidenced by this Warrant Certificate are part of a duly
authorized issue of Warrants issued pursuant to the Warrant Agreement, which
Warrant Agreement is hereby incorporated by reference in and made a part of this
instrument and to which reference is hereby

<PAGE>

made for a description of the rights, limitations of rights, obligations, duties
and immunities thereunder of the Company and the registered holder(s) of the
Warrants.

        As set forth in Section 7 of in the Warrant Agreement, certain
adjustments may be made to the Exercise Price and the type and/or number of the
Company's securities issuable upon their exercise. In the event of such an
adjustment, the Company will, at the request of the holder, issue a new Warrant
Certificate evidencing the adjustment in the Exercise Price and the number
and/or type of securities issuable upon the exercise of the Warrants; PROVIDED,
HOWEVER, that the failure of the Company to issue such new Warrant Certificates
shall not in any way change, alter or otherwise impair the rights of the holder
as set forth in the Warrant Agreement.

        Upon due presentment of transfer of this Warrant Certificate and the
executed form of assignment attached hereto at an office or agency of the
Company, a new Warrant Certificate or Warrant Certificates of like form and
tenor and evidencing in the aggregate a like number of Warrants shall be issued
to the transferee(s) in exchange for this Warrant Certificate, subject to the
limitations provided herein and in the Warrant Agreement, without any charge
except for any tax or other governmental charge imposed in connection with such
transfer.

        Upon the exercise of less than all of the Warrants evidenced by this
Warrant Certificate, the Company shall forthwith issue to the holder hereof a
new Warrant Certificate representing such number of unexercised Warrants.

        The Company may deem and treat the registered holder(s) hereof as the
absolute owner(s) of this Warrant Certificate (notwithstanding any notation of
ownership or other writing hereon made by anyone), for the purpose of any
exercise hereof, and of any distribution to the holder(s) hereof, and for all
other purposes, and the Company shall not be affected by any notice to the
contrary.

        All capitalized terms used and not defined in this Warrant Certificate
shall have the meanings ascribed to them in the Warrant Agreement.

            [THE REMAINDER OF THIS PAGE IS INTENTIONALLY LEFT BLANK]

<PAGE>

        IN WITNESS WHEREOF, the Company has caused this Warrant Certificate to
be duly executed as of _____________ __, 200_.

                                            VYTERIS, INC.

                                            By:_________________________________
                                               Name: Vincent L. DeCaprio, Ph.D.
                                               Title: President

Attest:

-------------------------
Secretary

<PAGE>

                         [FORM OF ELECTION TO PURCHASE]

TO:     Vyteris, Inc.
        Attention:  President

        1.      The undersigned hereby irrevocably elects to exercise the right,
represented by the attached Warrant Certificate, to purchase _______________
(leave blank if you choose Alternative No. 2 below) shares of Common Stock
pursuant to the terms of the Warrant Agreement entered into by and among
Vyteris, Inc. and the holders of the Warrants, dated __________ ___, 200__ (the
"Warrant Agreement"), and tenders herewith payment of the purchase price of such
shares in full. (Initial here if the undersigned elects this alternative).
_________

        2.      In lieu of exercising the attached Warrant Certificate for cash
or check, the undersigned hereby elects to effect the net exercise provision set
forth in Section 3.2 of the Warrant Agreement and receive ____________ (leave
blank if you choose Alternative No. 1 above) shares of Common Stock of the
Company. (Initial here if the undersigned elects this alternative). ___________

        Capitalized terms used and not herein defined shall have the meanings
ascribed to them in the Warrant Agreement.

        Please issue a certificate or certificates representing said securities
in the name of the undersigned or in such other name as is specified below:

                    ----------------------------------------
                                     (Name)

                    ----------------------------------------

                    ----------------------------------------
                                    (Address)

                                   --------------------------------------------
                                   (Signature and Date)

                                   (Signature must conform in all respects to
                                   name of holder as specified on the face of
                                   the Warrant Certificate)

                                   --------------------------------------------
                                   (Insert Social Security or Other Identifying
                                   Number of Holder)

<PAGE>

                              [FORM OF ASSIGNMENT]

             (To be executed by the registered holder if such holder
                  desires to transfer the Warrant Certificate)

        FOR VALUE RECEIVED ________________________________ (the "Transferor")
hereby sells, assigns and transfers unto _____________________________________
(the "Transferee")

                  (Please print name and address of transferee)

this Warrant Certificate, together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint ______________________ as its
Attorney to transfer the within Warrant Certificate on the books of Vyteris,
Inc., with full power of substitution. The Transferor has provided a written
instrument to the Company notifying the Company of such transfer and pursuant to
which the Transferee hereunder has agreed in writing to be bound by the terms of
the Warrant Agreement dated __________ __, 200__ by, between and among Vyteris,
Inc., a Delaware corporation, and the holders of the Warrants a copy of which
has been provided to the Transferee by the Transferor.

Dated:                             Signature___________________________________
                                   (Signature must conform in all respects to
                                   name of holder as specified on the face of
                                   the Warrant Certificate)

                                   ____________________________________________
                                   (Insert Social Security or other Identifying
                                   Number of Holder)

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00074-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00074-of-00352.parquet"}]]