Document:

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                                                                    EXHIBIT 10.1

                            FIRST AMENDMENT TO LEASE

     This First Amendment to Lease (the "Amendment") is entered into as of the
26th day of July, 1995, by and among ALLSTON LANDING LIMITED PARTNERSHIP, a
Massachusetts limited partnership, with offices at One Kendall Square,
Cambridge, Massachusetts 02139 ("Tenant"), and MASSACHUSETTS TURNPIKE AUTHORITY,
a body politic and corporate organized pursuant to the laws of the Commonwealth
of Massachusetts with offices at Ten Park Plaza, Suite 5170, Boston,
Massachusetts 02116 ("Landlord"). Terms used in this Amendment, which are not
defined herein, shall have the meanings set forth in the Lease (defined below).

     Reference is made to the following facts:

     A.   Landlord and Tenant are parties to a certain lease, dated as of June
1, 1992 (the "Lease"), for certain premises containing 375,325 square feet of
land, bounded by Soldiers Field Road, Western Avenue and other land of Landlord,
as more particularly described in the Lease (the "Premises").

     B.   Pursuant to the Lease, Tenant has constructed a manufacturing facility
and certain improvements (the "Improvements") on a portion of the Premises.

     C.   Tenant had requested, and Landlord had agreed, that Tenant could
construct the so-called "Tank Farm" for such manufacturing facility at a
location outside of the boundaries of the portion of the Premises identified in
the Lease as the initially established Development Parcel. Accordingly, Landlord
and Tenant now wish to revise the boundaries of the Development Parcel to
include such, "Tank Farm Area" (being approximately 5,154 square feet in area)
and to confirm certain other matters in connection with the Improvements
constructed by Tenant on the Premises.

     NOW, THEREFORE, in consideration of the foregoing and for other good and
valuable consideration, the receipt of which is hereby acknowledged, Landlord
and Tenant hereby agree, effective as of the date of this Amendment, as follows:

     1.   The Appendix A originally attached to and made a part of the Lease is
hereby deleted in its entirety, and the new Appendix A (Rev. 5/31/95) attached
to this Amendment is substituted in place thereof.

     2.   With respect to the Improvements constructed by Tenant on the
Development Parcel, Landlord and Tenant hereby agree, based upon the
certifications of Tenant's architect, Architectural Resources Cambridge, Inc.,
and Certificate of Occupancy No. 30643 dated July 6, 1994, issued by the City of
Boston's Inspectional Services Department, as follows:

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          (a)  To the best of Tenant's knowledge, such Improvements have been
completed in accordance with the plans therefor submitted to and approved by
Landlord in accordance with Landlord's design approval rights under Section
3.2.2 of the Lease. For purposes of this Amendment, any statement made "to the
best of a party's knowledge" shall mean that nothing has come to the actual
attention of the individual officers or senior staff or representatives of such
party participating directly in the management or supervision of the matter at
issue that would lead such individuals to question the accuracy of such
statement, but that such individuals have not made any special investigation
with respect thereto.

          (b)  As of July 6, 1994, such Improvements contain 130,490 square feet
of FAR Floor Area and the initial Development Parcel Rent payable by Tenant with
respect to such Improvements in accordance with Section 4.1.2 of the Lease shall
be $234,882 per year.

          (c)  As of June 1, 1995, the Holding Parcel Rent payable by Tenant
with respect to the initially established Holding Parcel shall be $124,364 per
year.

          (d)  Landlord hereby acknowledges and agrees that as of April 8, 1992,
Tenant "Commenced Material and Substantial Construction" of 130,490 square feet
of FAR Floor Area on the Development Parcel.

     3.   Landlord hereby grants to Tenant the right to grant an easement for a
term of years (not to extend beyond the expiration or earlier termination of the
Lease) to Boston Edison Company for the construction, installation, operation,
use, inspection, maintenance, modification, replacement, repair and removal of:
(i) certain underground electrical ductbanks, manholes and a generator pad on
the Holding Parcel in the locations shown on the plan entitled "Plan of the
Genzyme Manufacturing Facility -- Existing Underground Utilities (Outside of the
Development Parcel)" dated May 18, 1994, last revised May 31, 1995, a copy of
which is attached as part of Appendix A hereto (the "Utilities Plan "); and (ii)
certain underground electrical ductbanks and a manhole off the Premises on other
property of Landlord in the location shown on the plan entitled "Boston Edison
Company Electrical Engineering &Station Operations Department Plan of Soldiers
Field Road, Brighton, Showing Proposed Conduit and Manhole Location," Plan
#P-1786c, dated September 10, 1992 (the "Boston Edison Plan"), a reduced copy of
which is attached as Appendix B hereto. The locations of the utility facilities
identified in (i) and (ii) above may be relocated from time to time either (x)
at the direction of Landlord pursuant to Landlord's relocation privileges under
Section 2.1 of the Lease, or (y) as Tenant may request and Landlord may approve
in writing, such approval to be in Landlord's sole discretion. The foregoing
right and easement shall be subject to the following conditions:

     (a)  Such construction, maintenance, modification, replacement, repair and
          removal shall be at Tenant's sole expense. Tenant shall at Tenant's
          sole expense cause the property crossed by such electrical facilities
          promptly to be restored to a condition acceptable to Landlord's Chief
          Engineer after each occasion on which Tenant performs any such work.

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     (b)  Such right and easement shall be nonexclusive, and in common with
          similar rights and easements which Landlord may grant to others from
          time to time.

     (c)  The exercise of such right and easement by Tenant and Boston Edison
          Company shall not interfere with Landlord's use of the property
          crossed by such electrical facilities including, without limitation,
          the use of such property for 24-hour access to the Massachusetts
          Turnpike, whether over existing ramps and access ways or ramps and
          ways hereafter constructed and/or relocated from time to time.

     (d)  At Landlord's election after the expiration or earlier termination of
          the Lease, Tenant shall at Tenant's sole expense promptly relocate
          and/or remove such electrical facilities and restore the property to a
          condition acceptable to Landlord's Chief Engineer.

     (e)  The foregoing right and easement granted to Tenant shall be subject to
          all of the terms and provisions imposed upon Tenant by the Lease.

     (f)  Any easement granted to Boston Edison Company by Tenant pursuant to
          this Paragraph 3 shall be subject to the foregoing conditions and
          shall also be subject to Landlord's prior written approval as to form
          and substance. Attached hereto as Appendix C is a form of easement
          setting forth the minimum material provisions required by Landlord to
          be contained in any such easement.

     4.   Landlord hereby acknowledges that the electrical facilities described
in Paragraph 3 above and a number of other utility lines serving the Development
Parcel, as well as a generator pad and fencing, are located on the Holding
Parcel (as such Parcels are currently configured). Such utility lines, generator
pad and fencing are located as shown on the Utilities Plan. Such other utility
lines include the lines for drain, sewer, fire protection water and domestic
water services. Tenant acknowledges that Landlord retains the right to require,
among other things, the relocation of such utility lines, generator pad and
fencing from time to time pursuant to Section 2.1 of the Lease. Landlord agrees
that to the extent Landlord exercises its right to terminate the Lease as to the
Holding Parcel (or a portion thereof) pursuant to Article II of the Lease or
pursuant to the last sentence of Section 2.1 of the Lease, the right and
easement granted under Paragraph 3 of this Amendment, and any resulting easement
granted by Tenant, shall be deemed to have been simultaneously terminated as to
the Holding Parcel (or such portion thereof) PROVIDED, HOWEVER, that Tenant
shall continue to have, as rights appurtenant to the lease of the remaining
Premises, the right to use such electrical facilities and such other utility
lines, generator pad and fencing as now located (or as relocated from time to
time pursuant to Paragraph 3 of this Amendment, or pursuant to Section 2.1 of
the Lease).

     5.   Landlord's and Tenant's liability under this Amendment shall be
limited, respectively, as set forth in Sections 10.2 and 10.12 of the Lease.

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6.   Except as amended hereby, the Lease remains unchanged and in full force and
effect.

     IN WITNESS WHEREOF, the parties hereto have executed this Amendment to
Lease as a sealed instrument as of the date and year first above written.

TENANT:                                    LANDLORD:
ALLSTON LANDING LIMITED                    MASSACHUSETTS TURNPIKE
PARTNERSHIP                                AUTHORITY

By: Allston Landing Corporation,
        By:
           ------------------------------
        its sole General Partner By:

By:                                        By:
     ---------------------------------        ----------------------------------
        Its Treasurer

                                           By:
                                              ----------------------------------

                                           Approved:
                                                    ----------------------------
                                                        James A. Aloisi, Jr.
                                                        General Counsel

     By its signature below, the undersigned Guarantor of the Lease hereby
acknowledges and consents to the foregoing First Amendment and ratifies and
confirms its Guaranty dated as of June 1, 1992, with respect to the lease as
amended through the First Amendment.

                                           GUARANTOR:

                                           GENZYME CORPORATION

                                           By:
                                              ----------------------------------
                                              Its Senior Vice President

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                            Appendix A (Rev. 5/31/95)

                    Premises Description, Including Initially
                 Established Development Parcel, Holding Parcel
                             and Inaccessible Parcel

     Attached hereto are the following:

     Page A-2:                This is a reduced copy of a "Plan of Land in
                              Boston, MA." dated February 26, 1992, scale 1 inch
                              = 100 feet, prepared for Allston Landing Limited
                              Partnership (the "Premises Plan ").

     Pages A-3
     and A-4:                 These pages contain a legal description of the
                              Premises.

     Page A-5:                This is a copy of a "Plan of the Genzyme
                              Manufacturing Facility Existing Underground
                              Utilities (Outside of the Development Parcel) in
                              Boston, MA.", Scale 1" = 40', dated May 18, 1994,
                              revised November 9, 1994, and last revised May 31,
                              1995 prepared by Vanasse Hangen Brustlin, Inc.,
                              prepared for Allston Landing Limited Partnership
                              (the "Phase I Plan").

     Pages A-6
     and A-7:                 These pages contain a legal description of the
                              Development Parcel.

     For purposes of this Lease:

     The "Premises" constitutes the area identified on the Premises
     Plan as the "Project Area (Area = 8.62 acres)" and described in
     the legal description on Pages A-3 and A-4.

     The initially established "Development Parcel" constitutes the
     area identified on the Phase I Plan as the "Phase I Lease Area
     (Area = 126,597 square feet or 2.906 acres)" and described in the
     legal description on Pages A-6 and A-7.

     The initially established "Holding Parcel" constitutes all of the
     Premises except for the initially established Development Parcel.
     As shown on the Phase I Plan, the area of the initially
     established "Holding Parcel" contains 248,728 square feet or
     6.710 acres.

     The "Inaccessible Parcel" (Area = 63,130 square feet or 1.449
     acres) constitutes that portion of the initially established
     Holding Parcel shown as shaded on the Phase I Plan.

N 06 DEG. 30' 13 W                 a distance of two hundred ninety-three and
                                   seventy-three hundredths feet (293.73') to a
                                   point thence

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                                 [APPENDIX A-2]

                         [GRAPHIC IMAGE OF PROJECT AREA]

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                                       A-3

                                    PREMISES
                                LEGAL DESCRIPTION

A certain parcel of land situated on the southerly side of Western Avenue in the
City of Boston (Allston District), in the County of Suffolk, Commonwealth of
Massachusetts, bounded and described as follows:

Beginning at a point in the southerly line of Western Avenue at the
northeasterly corner of the parcel and land hereinafter described, said point
being the northwesterly corner of Lot 8 as shown on Land Court Plan No. 21781-E;
thence

S 06 DEG. 30' 13" E           A distance of two hundred fifty and three
                              hundredths feel (250.03') to a point; thence

N 83 DEG.  17' 27" E          A distance of one hundred thirteen and seventy-two
                              hundredths feel (113.72') to a point; the previous
                              two (2) lines bounding on said Lot 8; thence

S 06 DEG.  42' 33' E          A distance of five hundred sixty five and no
                              hundredths feet (565.00') to a point; thence

Southerly                     And curving to the right along the arc of a curve
                              having a radius of one hundred ninety and no
                              hundredths feet (190.00'), a length of one hundred
                              seven and eighty seven hundredths feet (107.87')
                              to a point; thence

Westerly                      And curving to the right along the arc of a curve
                              having a radius of eighty four and no hundredths
                              feet (84.00'), a length of one hundred fifty eight
                              and fourteen hundredths feet (158.14') to a point;
                              thence

N 46' 19' 00" W               A distance of one hundred and no hundredths feet
                              (100.00') to a point; thence

Westerly                      And curving to the left along the arc of a curve
                              having a radius of two hundred five and no
                              hundredths feet (205.00'), a length of three
                              hundred one and sixty hundredths feet (301.60') to
                              a point; thence

N 02 DEG.  30' 24" W          A distance of seven hundred fifty three and forty
                              seven hundredths feet (753.47') to a point; thence

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                                       A-4

                                    PREMISES
                                LEGAL DESCRIPTION

Northwesterly                 And curving to the left along the arc of a curve
                              having a radius of fifty five and no hundredths
                              feet (55.00'), a length of ninety and twenty three
                              hundredths feet (90.23') to a point in the
                              southerly line of said Western Avenue; the
                              previous seven (7) courses bounding on land now or
                              formerly of the Massachusetts Turnpike Authority;
                              thence

N 83 DEG. 29' 47" E           A distance of three hundred eighty eight and no
                              hundredths feet (388.00') along the southerly line
                              of said Western Avenue to the point of beginning.

The above described parcel of land contains an area of 8.62 areas more or less
and is more particularly shown as 'Project Area' on a plan entitled: "Plan of
Land in Boston, Massachusetts. Dated February 26, 1992, scale: 100 feet to an
inch, prepared for Allston Landing Limited Partnership, prepared by Vanasse
Hangan Brustlin, Inc., 101 Walnut Street, Watertown, MA.

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                                       A-6

(VHB logo here)                  LEGAL DESCRIPTION
                                PHASE ONE LEASE AREA
                                      GENZYME
                               (REVISED MAY 31, 1995)

A certain parcel of land situated on the southerly side of Western Avenue in the
City of Boston (Allston District), county of Suffolk, Commonwealth of
Massachusetts, bounded and described as follows:

Beginning at a point in the southerly line of Western Avenue at the
northwesterly corner of the parcel of land hereinafter described, said point
being the northwesterly corner of Lot 8 as shown on Land Court Plan 21781E;
thence

S 06 DEG. 30' 13" E      A distance of two hundred fifty and three hundredths
                         feet (250.03') to a point; thence

N 83 DEG. 17' 27" E      A distance of one hundred thirteen and seventy-two
                         hundredths feet (113.72') to a point; thence

S 06 DEG. 42' 33" E      A distance of three hundred eighty-six and eleven
                         hundredths feet (386.11') to a point; thence

S 83 DEG. 29' 47" W      A distance of one hundred thirty-six and sixty
                         hundredths feet (136.60') to a point; thence

S 06 DEG. 30' 13" E      A distance of seventy-three and no hundredths feet
                         (73.00') to a point; thence

S 83 DEG. 29' 47" W      A distance of one hundred twenty and no hundredths feet
                         (120.00') to a point; thence

S 06 DEG. 30' 13" E      A distance of thirty and no hundredths feet (30.00') to
                         a point; thence

S 83 DEG. 29' 47" W      A distance of one hundred sixty-seven and no hundredths
                         feet (167.00') to a point; thence

N 06 DEG. 30' 13" W      A distance of forty-seven and no hundredths feet
                         (47.00') to a point; thence

N 83 DEG. 29' 47" E      A distance of one hundred two and no hundredths feet
                         (102.00') to a point; thence

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N 06 DEG. 30' 13" W      A distance of seventy-eight and no hundredths feet
                         (78.00') to a point; thence

N 83 DEG. 29' 47" E      A distance of fifty-one and eleven hundredths feet
                         (51.11') to a point; thence

N 06 DEG. 30' 13" W      A distance of three hundred twenty and no hundredths
                         feet (320.00') to a point; thence

N 83 DEG. 29' 47" E      A distance of one hundred twenty-eight and thirty-nine
                         hundredths feet (128.39') to a point; thence

N 06 DEG. 30'13" W       A distance of two hundred ninety-three and
                         seventy-three hundredths feet (293.73') to a point;
                         thence

N 83 DEG. 29' 47" E      A distance of twenty-seven and no hundredths feet
                         (27.00') by the southerly line of Western Avenue to the
                         point of beginning.

The above described parcel of land contains 2.906 acres of land, more or less,
and is shown on a plan entitled "Plan of the Genzyme Manufacturing Facility,
Phase I Lease Area in Boston, Massachusetts, dated May 22, 1992 and most
recently revised May 31, 1995, prepared by Vanasse Hangen Brustlin, Inc.

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                                  [APPENDIX B]
                    [GRAPHICS IMAGE OF SOLDIER'S FIELD AREA]

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                                                                      APPENDIX C

                               EASEMENT AGREEMENT

THIS EASEMENT AGREEMENT (the "Agreement") made as of this ___ day of __________,
1993 by and between Allston Landing Limited Partnership, a Massachusetts limited
partnership having an office address of ________________________________________
(herein referred to as "ALLP") and Boston Edison Company, a Massachusetts
Corporation having its corporate office at 800 Boylston Street, Boston, MA 02199
(herein referred to as "Boston Edison").

                                    RECITALS

     NOW THEREFORE, IN CONSIDERATION OF THE PROMISES AND OF THE MUTUAL
AGREEMENTS HEREIN CONTAINED, AND OTHER GOOD AND VALUABLE CONSIDERATION, THE
SUFFICEIENCY OF WHICH IS HEREBY ACKNOWLEDGED BY THE PARTIES, THE PARTIES HEREBY
AGREE AS FOLLOWS:

1.   AGREEMENTS AND GRANTS

A.   ALLP hereby grants to Boston Edison, upon the terms and conditions set
forth in this Agreement, an easement to construct, install, operate, use,
inspect, maintain, modify, replace, repair, and remove an electrical system and
any and all fixtures, all of which shall be and remain the property of Boston
Edison to be used only in connection with electrical service in accordance with
detailed plans set forth in Exhibit A attached hereto and made a part hereof,
(referred to herein as "the Plans"). The exact location of the electrical system
and of the easement including its dimensions, has been substantially determined
by ALLP and Boston Edison. ___________________ and Boston Edison agree to allow
minor alterations to the location of the electrical system to accommodate
circumstances that arise prior to and during construction. Upon completion of
construction of the electrical system, Boston Edison shall submit to ALLP and to
ALLP's landlord, the Massachusetts Turnpike Authority ("Authority") a set of
as-built plans depicting the exact location of the easement. The area which is
the subject of this easement is identified in the plans and shall be referred to
herein as the "Easement Area."

Prior to the installation by Boston Edison of any modifications, replacements,
substitutes, additions, innovations or improvements to the electrical system,
Boston Edison shall submit plans and specifications to ALLP and to the
Authority's Chief Engineer for review and approval, which approval shall not be
unreasonably withheld, and which approval shall be granted or denied within 60
days of receipt by ALLP and the Authority of a written proposal by Boston
Edison.

B.   The rights herein granted to Boston Edison include the right of ingress and
egress over the adjacent property of the Authority from time to time for the
construction,

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installation, operation, use, inspection, maintenance, modification,
replacement, repair, and removal of the electrical system by Boston Edison, its
employees, agents and contractors, under the direction and supervision of the
Authority in accordance with the Operation and Construction Requirements set
forth in Exhibit B attached hereto and made part hereof. The Authority has
reserved the right from time to time to make reasonable changes in such
requirements. Boston Edison will conform to such changes within a reasonable
time after it has received written notice thereof from the Authority. The
Authority shall allow Boston Edison, its employees, agents and contractors
reasonable access to the Easement Area and the electrical system throughout the
term of the Agreement, subject to reasonable regulation regarding traffic flow,
public health and safety and the Authority's own operations on the Turnpike.
Vehicles of Boston Edison, its employees, agents and contractors may enter and
leave the turnpike only at toll plazas. Operators of such vehicles shall pay all
applicable tolls which shall be the same tolls applicable to similar vehicles
driven by the general public.

2.   TERM

The term of this easement is coterminous with the term of that certain lease
("Lease") from the Authority to ALLP dated as of June 1, 1992, as amended
through that First Amendment to Lease dated __________________, 1993. To the
extent Authority exercises its right to terminate the Lease as to the Holding
Parcel (or a portion thereof) pursuant to Article II of the Lease, the foregoing
right granted to ALLP and any resulting easement granted by ALLP shall be deemed
to have been simultaneously terminated by Landlord as to the Holding Parcel (or
such portion thereof), and at Landlord's election thereafter ALLP shall at
ALLP's sole expense promptly relocate and/or remove the electrical facilities
and restore the property to a condition acceptable to Authority's Chief
Engineer.

3.   RESTORATION

Boston Edison agrees to restore the Easement Area, at its own expense,
immediately upon completion of construction, to a condition acceptable to the
Chief Engineer, in accordance with Exhibit B.

4.   AUTHORITY'S RESERVED RIGHTS

ALLP and the Authority reserve the right to grant to others, including
competitors of Boston Edison, rights to those granted hereunder. No easements or
other rights granted by ALLP to Boston Edison are exclusive, except to the
extent expressly stated in this Agreement.

ALLP and the Authority each reserve the right for its employees, agents,
grantees and assigns to enter upon any portion of property in which rights have
been granted to Boston Edison hereunder for any purpose deemed necessary by the
Authority's Chief Engineer in connection with the construction, reconstruction,
or maintenance of the Turnpike or Authority-owned installations and appurtenants
thereto. The Authority shall give Boston Edison reasonable advance notice of all
proposed uses of the Easement Area and the opportunity to prevent any such use
which may unreasonably interfere with the rights granted by this Agreement. The
Authority shall exercise reasonable care in the

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performance of any work theron to avoid physical damage to the electrical
system. If such damage does occur, the Authority shall reimburse Boston Edison
for its reasonable costs in restoring such damaged portions to the electrical
system to the same condition as existed prior to such damage. In no event shall
the Authority be liable to Boston Edison or ALLP for any delay, consequential,
special or incidental damages, including, but not limited to, lost profits and
revenues, resulting from any such damage to the electrical system, fixtures or
equipment or any other property of Boston Edison.

Boston Edison will not interfere with the exercise by others of rights
consistent with this Agreement granted or to be granted them.

5.   INDEMNIFICATION

Boston Edison, on behalf of itself, its agents, employees, contractors or
subcontractors, assumes all risk of repair, maintenance, operation, removal or
relocation of the electrical system, or any portion thereof, and shall be solely
responsible and answerable in damages for any and all accidents and injuries to
person or property, including death. Boston Edison hereby covenants and agrees
to indemnify and hold harmless each of ALLP and the Authority from all claims,
suits, actions, damages, and costs of every nature and description, arising out
of or relating to the repair, maintenance, operation, removal or relocation of
the electrical system or any portion thereof, by Boston Edison, its agents,
employees, contractors or subcontractors or the violations of any law,
ordinance, rule or regulation by them or any of them in connection therewith.
Boston Edison shall, upon request, defend at its own cost and expense any action
brought at any time against ALLP or the Authority in connection with any such
claims or suits. Upon receipt by ALLP or the Authority of notice of any claim,
suit, action, damage or cost covered by the hold harmless provisions of this
paragraph, ALLP or the Authority shall notify Boston Edison thereof promptly and
in writing. This indemnification obligation shall survive the expiration or
earlier termination of this Easement Agreement.

6.   NUISANCE

Boston Edison, for itself and its successors, assigns and agents, covenants and
agrees to place no signs, structures, buildings or parts thereof upon the
Authority's property and to do nothing on such property to render such areas
unsightly or offensive.

7.   TAXES

Boston Edison shall pay and discharge or cause to be paid and discharged any and
all taxes, assessments and governmental charges or payments in lieu thereof
(except any tax, assessment or other charge on the income of ALLP or the
Authority) that shall or may be levied, assessed, or imposed during the term of
this Agreement by any governmental or other lawful authority (except the
Authority) upon or against ALLP or the Authority or Boston Edison arising out of
the rights granted to Boston Edison hereunder.

8.   AUTHORITY'S REMEDIES

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If Boston Edison shall fail materially to perform or observe any of the
covenants, agreements, duties and conditions on its part to be performed or
observed under this Agreement, and such failure shall continue unremedied after
thirty (30) days' written notice to Boston Edison of the failure therof, either
ALLP or the Authority shall have the right, at its election, to terminate this
Agreement. Such right shall be in addition to all other rights or remedies
available to it in law or in equity. All rights of ALLP and of the Authority
against Boston Edison accruing or arising prior to termination shall survive
such termination. In the even Boston Edison has commenced remedial action and is
making good faith efforts diligently to complete such action, ALLP and the
Authority will not have the right to terminate this Agreement.

Upon failure, neglect or refusal of Boston Edison, upon notice in writing to
Boston Edison from ALLP or the Authority, to perform or to commence to perform
and diligently pursue in good faith to completion within a reasonable time any
repair work hereunder, ALLP or the Authority may undertake and perform such
repair work, and upon receipt of bills for such repair work from ALLP or the
Authority may undertake and perform such repair work, and upon receipt of bills
for such repair work from ALLP or the Authority, Boston Edison shall forthwith
reimburse ALLP or the Authority, as the case may be, for such costs reasonably
so incurred.

9.   RELOCATION

In the event it shall become necessary to rearrange or relocate the electrical
system to accommodate changes or improvements on the Turnpike, and such
rearrangements or relocations are reasonably required for such purposes, the
relocation work will be made by Boston Edison at its sole expense upon receipt
of written notice from the Authority or ALLP to do so. If Boston Edison shall
fail (a) to perform such work, or (b) within forty (40) days of receipt of such
written notice, to inform ALLP and the Authority of its intention to perform
such work and to furnish ALLP and the Authority with a reasonable schedule for
doing such work, each of ALLP and the Authority shall have the right, at its
option, to perform such work, at the risk and expense of Boston Edison.

The provisions of this paragraph are for the exclusive protection of ALLP and
the Authority, and Boston Edison shall not be required to relocate any portion
of the electrical system because of any conflict between Boston Edison's
facilities and improvements contemplated or requested by other parties. ALLP and
the Authority will fully cooperate with Boston Edison to the end that such
changes and relocations of the electrical system may be held to the minimum
necessary to accomplish the Authority's purposes. When an alternative method by
which the Authority can accomplish its purpose is available and such alternative
method would not necessitate relocation of the electrical system and, in the
judgment of the Authority such alternative method is substantially equal in cost
and feasibility, the Authority will adopt such alternative method and will
permit the electrical system to remain in place or will disturb it as little as
possible.

10.  ASSIGNMENT

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Boston Edison may, upon forty-five (45) days' prior notice, assign or transfer
its rights hereunder, in whole or in part, to any other entity with the prior
written consent of the Authority, which consent shall not be unreasonably
withheld, but no assignment shall act to expand the grant of easement allowing
the Easement Area to be used for purposes not specifically provided for in
Section 1, hereinabove.

11.  NONDISCRIMINATION

In all matters pertaining to its exercise of its rights hereunder, Boston Edison
will comply with all applicable discrimination statutes, including Massachusetts
General Laws c.151B, and with all applicable Authority rules and regulations for
affirmative action.

12.  INSURANCE

Boston Edison will maintain in force at its expense, during the term of this
Agreement, the following insurance:

     (i)     Comprehensive bodily injury, personal injury and property damage
             liability insurance, including Blanket contractual Liability, Broad
             Form Comprehensive Liability insurance and products, Completed
             Operations and XCU (Explosion, Collapse, and Underground) hazards
             insurance, to a limit not less than ten million dollars
             ($10,000,000) combined single limit;

     (ii)    Comprehensive Auto Liability insurance for vehicles owned, leased,
             rented, or otherwise used to a limited of not less than five
             million dollars ($5,000,000);

     (iii)   Workers Compensation and Employer's Liability insurance, including
             All States and Longshoreman's and Harbor Worker's Act coverage for
             that amount as required by statute and limit of not less than five
             million dollars ($5,000,000) liability coverage; and

     (iv)    Such additional insurance in such types, coverages and amounts as
             from time to time may be reasonably required by the Authority and
             such increases in the amounts provided for hereinabove in
             subparagraphs (i), (ii), and (iii) as from time to time may
             be reasonably required by ALLP or the Authority.

Boston Edison shall make reasonable efforts to ensure that all such policies
shall include a provision that acts or omissions of Boston Edison shall not
preclude coverage for ALLP and for the Authority.

All insurance required hereunder shall be effected with insurers acceptable to
ALLP and the Authority and under valid and enforceable policies naming Boston
Edison, ALLP and the Authority as their interests appear, as insureds
thereunder. Any insurer rated A or higher in Best's Insurance Manual shall be
deemed acceptable to ALLP and to the Authority. All insurance required
hereunder:

                                       C-5
<Page>

     (i)     Shall provide by endorsement for immediate written notice to ALLP
             and to the Authority of any material change in coverage or
             conditions and at least thirty (30) days' prior written notice to
             ALLP and to the Authority if coverage is to be cancelled or
             renewed; and

     (ii)    Shall be evidenced by promptly furnishing ALLP and the Authority
             with certificates of insurance.

13.  TURNPIKE LOSS OF REVENUE

Any loss of toll, lease, easement or rental revenue by the Authority of any kind
resulting from a leak or other incident cause directly or indirectly by the
operation or installation of the electrical system or in any way attributed to
the electrical system shall be reimbursed to the Authority by Boston Edison. Any
such loss by the Authority shall be documented and forwarded by Registered Mail
to Boston Edison within forty-five (45) days after such incident or occurrence.
Any amount owed the Authority by Boston Edison shall be paid within thirty (30)
days of such documentation. Amounts owed the Authority pursuant to this section
remaining unpaid after the thirtieth (30th) day shall bear interest at the prime
commercial rate of the First National Bank of Boston, as it may be adjusted from
time to time.

14.  NOTICE

Every notice, demand and approval required or permitted to be given under this
Agreement shall be in writing and deemed to have been duly given only when
mailed by certified or registered mail, with return receipt requested, addressed
in the case of notice or demand upon the Authority to it at:

     Director of Development and Planning
     Massachusetts Turnpike Authority
     State Transportation Building
     10 Park Plaza, Suite 5170
     Boston, MA 02116

And in the case of notice to or demand upon Boston Edison, to it at:

     W.B. Arcese, Jr.
     ROW Supervisor
     Boston Edison Pipeline Company
     8 Anngina Drive
     Enfield, CT 06082

And in the case of notice to or demand upon ALLP, to it at:

                                       C-6
<Page>

or in the case of either party to such other address as that party from time to
time shall have designated by written notice given to the other party, as herein
provided.

15.  RECORDING

In accordance with the provisions of M.G.L. c.183, Section 4, ALLP and Boston
Edison shall record this Easement Agreement with the Suffolk County Registry of
Deeds.

16.  COMPLIANCE WITH LAWS

Boston Edison shall comply with all applicable state and federal statutes
relative to environmental protection in the construction, installation and
operation of the electrical system, including, all local ordinances and
conservation commission requirements of any city or town in which the electrical
system in the Easement Area may be located.

Boston Edison shall comply with the provision of M.G.L. c.7, Section 40J, by
filing with the Commonwealth of Massachusetts Commissioner of Administration and
Finance for Capital Planning and Operation, prior to the execution of the
Agreement and also from time to time during the term of this Agreement, all
disclosure statements required by said statute.

Pursuant to M.G.L. c.62C, Section 49A, Boston Edison certifies under the pains
and penalties of perjury that Boston Edison is in compliance with all laws of
the Commonwealth of Massachusetts relating to taxes.

IN WITNESS WHEREOF, the parties have caused this Agreement to be executed on
their behalf by their duly authorized representatives as of the date first set
forth above

                                [SIGNATURE BLOCK]

                                       C-7
<Page>

                                    EXHIBIT B

                    CONSTRUCTION AND OPERATIONAL REQUIREMENTS
                TO BE ATTACHED TO THE LEASE OF EASEMENT AGREEMENT
                BETWEEN THE AUTHORITY AND BOSTON EDISON PIPELINE

1.   Boston Edison shall obtain a permit from the Authority for work performed
     within the Authority property. No work shall be done on property of the
     Authority until such time as Boston Edison shall have communicated with
     P. L. Matson, the Authority's Maintenance Engineer, whose office is at 668
     South Avenue, Weston, Massachusetts, telephone: (617) 431-5120, and Al
     Abdella, Division Engineer, telephone: (617) 431-5149, and received from
     them permission to commence work and such further instructions as they may
     deem necessary in the performance of the work on the Turnpike property.

2.   All operation within Turnpike property shall be subject to the directions
     of the Authority's Engineer and the State Police Captain. They shall have
     the right to stop all work due to traffic considerations, weather
     conditions, or for any other reason that, in their opinion, would affect
     the safe operation of the Turnpike.

3.   Operations shall be conducted so as to cause minimum interference with
     Turnpike traffic and operations. The work area shall be kept open to
     traffic at all times except as may be authorized or directed by the
     Authority's Engineer.

4.   All work shall be performed in accordance with all governing local, state
     and Federal rules, codes, laws, ordinance and regulations.

5.   It shall be the responsibility of Boston Edison to notify the public
     service corporations and/or municipal departments 72 hours before digging.
     Further, a 72 hour advance call shall be made to the Dig Safe Center
     (Telephone: 1-800-322-4844).

6.   If blasting is necessary, the approval of the Chief Engineer of the
     authority shall be secured. No fewer than two days in advance the Engineer
     will, for the protection of traffic, assign police details and other
     necessary personnel of the Authority, for which the Authority shall be
     reimbursed by Boston Edison at prevailing rates.

     The time during which explosives may be used is restricted to Monday
     through Thursday between the hours of 9:30 AM and 2:00 PM (Prevailing
     time). The use of explosives is not permitted on Friday, weekends (Saturday
     and Sunday), holidays. In order to minimize traffic disruptions, Boston
     Edison shall schedule blasting such that any two successive blasts
     detonated anywhere on the project are separated by at least two (2) hours.

     Boston Edison shall coordinate all blasting with the Authority's Engineer
     on site who shall determine in advance when the charges may be set.

                                       C-8
<Page>

     The maximum time for which traffic may be stopped at any single time shall
     be fifteen minutes, from the time traffic is stopped by police until all
     travel lanes are cleared of blast debris, to the satisfaction of the
     Engineer, and notice is given to the police that traffic may be resumed in
     both directions. If traffic is stopped for more than 15 minutes, Boston
     Edison shall pay to the Authority a penalty of $500 per minute for every
     minute traffic is stopped in excess of the 15 minute limit.

7.   Any excavation of the outside shoulders of the Turnpike roadways authorized
     to be left open overnight shall be protected by barricades and traffic
     control devices satisfactory to the Authority's Engineer.

8.   The Authority may assign representatives, generally referred to as
     Inspectors, as it reasonable deems necessary at the expense of Boston
     Edison and they shall be authorized to give directions with regard to the
     safety and convenience of the Turnpike traffic or of the public.

9.   All ears disturbed by this operation, including, but not limited to, the
     right of way, fence, highway guard, drainage structures, waterways, stone
     bounds, loam and seeding, shall be restored to the original condition
     satisfactory to the Authority's Engineer.

10.  All costs incurred by the Authority, including traffic protection and state
     police, if required, shall be reimbursed by Boston Edison at the prevailing
     rate.

11.  Upon completion of construction of the electrical system, Boston Edison
     shall submit to the Authority an "As-Built" plan showing the exact location
     and profile of the crossing.

                                      C-9<Page>

                                                                    EXHIBIT 10.2

                                                                  EXECUTION COPY

                           SECOND AMENDMENT TO LEASE

     This SECOND AMENDMENT TO LEASE (this "Second Amendment") is dated as of
this 22nd day of December, 1997, to be effective as of the 1st day of June,
1997, by and among MASSACHUSETTS TURNPIKE AUTHORITY, a body politic and
corporate organized pursuant to the laws of the Commonwealth of Massachusetts
with offices at Ten Park Plaza, Suite 5170, Boston, Massachusetts 02116
(hereinafter referred to as "LANDLORD"), ALLSTON LANDING LIMITED PARTNERSHIP, a
Massachusetts limited partnership with offices at One Kendall Square, Cambridge,
Massachusetts 02139 (hereinafter referred to as "TENANT"), and GENZYME
CORPORATION, with offices at One Kendall Square, Cambridge, Massachusetts 02139
(hereinafter referred to as "GUARANTOR").

                              W I T N E S S E T H:

     WHEREAS, Landlord and Tenant entered into that certain Lease dated as of
June 1, 1992, as amended by that certain First Amendment to Lease dated as of
July 26, 1995 by and between Landlord and Tenant (as amended, the "EXISTED
LEASE") for the demise of the land and improvements defined in the Existing
Lease as the "PREMISES", which Premises are comprised of therein described and
defined Development Parcel and Holding Parcel (which Holding Parcel includes the
Inaccessible Parcel) and which demise includes a right of first refusal to the
therein described and defined Adjoining Parcels;

     WHEREAS, initial capitalized terms used herein and not otherwise defined
shall have the meanings respectively ascribed to such terms in the Existing
Lease;

     WHEREAS, Section 2.1.2 of the Existing Lease provides that Landlord may
terminate the Existing Lease as to the Holding Parcel if Tenant has not
Commenced Material and Substantial Construction of at least 200,000 square feet
of FAR Floor Area of Improvements on the Holding Parcel by June 1, 1997;

     WHEREAS, Section 2.1.3 of the Existing Lease provides that, in addition to
Landlord's remedies set forth in Section 2.1.2 of the Existing Lease, Tenant
shall either provide access to Landlord over the Development Parcel in order to
provide access to the Inaccessible Parcel or pay Rent with respect to the
Inaccessible Parcel as if such Parcel was improved with 80,000 square feet of
FAR Floor Area of Improvements if Tenant has not Commenced Material and
Substantial Construction of at least 80,000 square feet of Improvements on the
Inaccessible Parcel by June 1, 1997;

     WHEREAS, no such Construction had commenced on either the Holding Parcel or
the Inaccessible Parcel as aforesaid as of June 1, 1997;

     WHEREAS, on account of no such Construction having commenced as aforesaid,
the Existing Lease grants Landlord the right to terminate the Existing Lease as
to the Holding Parcel;

<Page>

     WHEREAS, if the Existing Lease is terminated as to the Holding Parcel,
Tenant's rights to the Adjoining Parcels are terminated;

     WHEREAS, Tenant desires to continue to lease and develop the Holding Parcel
(inclusive of the Inaccessible Parcel) upon the terms and conditions set forth
herein; and

     WHEREAS, Landlord and Tenant desire to amend certain provisions of the
Existing Lease as more specifically set forth herein.

     NOW, THEREFORE, in consideration of the premises and mutual promises and
covenants contained herein and in the Existing Lease, and for other good and
valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, Landlord and Tenant hereby agree as follows:

     1. Definitions. The definitions of Adjusted Rent, Development Parcel Rent,
Holding Parcel Rent, Premises, Rent and Term as set forth in Section 1.1 of the
Existing Lease are hereby deleted in their entirety, and the following
definitions, in addition to the definition of Inaccessible Parcel Rent, are
respectively substituted therefor:

     "ADJUSTED RENT: Commencing on the 30th, and redetermined on the 40th, 50th
     and 60th anniversaries of the Date of Lease Execution (June 1, 1992), to be
     in effect as so determined for the respective ten Lease Years following the
     30th, 40th and 50th anniversaries and for the five Lease Years following
     the 60th anniversary, whichever is the lesser of (i) Fair Market Value
     Rent, assuming that the "MAXIMUM FAR FLOOR AREA OF IMPROVEMENTS" (defined
     as 130,490 square feet of initial Improvements plus the Maximum FAR Floor
     Area of Additional Improvements (as hereinafter defined)) have been
     constructed on the Premises, ascertained in accordance with $4.1.4 (but
     never less than Rent payable during the immediately preceding Lease Year)
     or (ii) the sum of (A) $1.80 multiplied by 130,490 (the total square feet
     of FAR Floor Area of initial Improvements constructed on the Development
     Parcel), increased by 5% per annum, cumulatively, from the Date of Lease
     Execution until the beginning of the Lease Year in question (calculated as
     [$1.80 (l+ (x) (. 05))x 130,490] (x being the Lease Year in question)),
     plus (B)(1)if either Landlord or Tenant terminate this Lease with respect
     to the Holding Parcel (exclusive of the Inaccessible Parcel) in accordance
     with Sections 4.2.1.1(e) and 4.2.1.1(f) of this Lease, respectively, the
     product of $1.80 multiplied by the greater of (v) 80,000 or (w) the total
     square feet of FAR Floor Area constructed on that portion of the Premises
     formerly referred to as the Inaccessible Parcel, increased by 5% per annum,
     cumulatively, from the Date of Lease Execution until the beginning of the
     Lease Year in question (calculated as [$1.80 (1+(x) (. 05)) x (y)] (x being
     the Lease Year in question and y being the greater of clause (v) and (w)
     above); or (2) if neither Landlord or Tenant terminate this Lease with
     respect to the Holding Parcel (exclusive of the Inaccessible Parcel) as
     provided herein, the product of $1.60 multiplied by 620,160 (the Maximum
     FAR Floor Area of Additional Improvements (as hereinafter defined)),
     increased by 5% per annum, cumulatively, from the Date of Lease Execution
     until the beginning of the Lease Year in question (calculated as [$1.60
     (1+(x)(. 05))x 620,160] (x being the Lease Year in question). (For an
     example, see Section 4.1.6.)

                                        2
<Page>

     DEVELOPMENT PARCEL RENT: The sum of (a) (i) from and after June 1, 1997,
     $272,724.10 per annum (100% of the product of $2.09 [$1.80 increased by
     16.1%, the CPI Escalation for the initial five Lease Years] multiplied by
     130,490 or the total square feet of FAR Floor Area of initial Improvements
     constructed on the Development Parcel) through the last day of the month in
     which the Development Plan Rent Commencement Date (as hereinafter defined)
     occurs, (ii) from and after the first day of the month following the
     Development Plan Rent Commencement Date, $245,451.69 per annum (90% of the
     product of $2.09 multiplied by 130,490) through the last day of the month
     in which the fifth anniversary of the Development Plan Rent Commencement
     Date occurs, and (iii) $272,724.10 per annum (100% of the product of $2.09
     multiplied by 130,490) for any period thereafter, PLUS (b) from and after
     the Development Plan Rent Commencement Date: (i) if either Landlord or
     Tenant terminate this Lease with respect to the Holding Parcel (exclusive
     of the Inaccessible Parcel) in accordance with Sections 4.2.1.1(e) and
     4.2.1.1(f) of this Lease, respectively, the product of $2.09 multiplied by
     the greater of (A) 80,000 or (B) the total square feet of FAR Floor Area
     constructed on that portion of the Premises formerly referred to as the
     Inaccessible Parcel; or (ii) if neither Landlord nor Tenant terminate this
     Lease with respect to the Holding Parcel (exclusive of the Inaccessible
     Parcel) as provided herein, $1,038,147.84 per annum (90% of the product of
     620,160, being the maximum FAR Floor Area of additional Improvements which
     could potentially be constructed on the Premises ("MAXIMUM FAR FLOOR AREA
     OF ADDITIONAL IMPROVEMENTS"), multiplied by $1.86 through the last day of
     the month in which the fifth anniversary of the Development Plan Rent
     Commencement Date occurs, and $1,153,497.60 per annum (100% of the product
     of the Maximum FAR Floor Area of Additional Improvements, multiplied by
     $1.86) for any period thereafter; subject to increase on the tenth
     anniversary of the Date of Lease Execution (June 1, 1992) and every fifth
     anniversary thereafter by the a mount equal to the CPI Escalation
     multiplied by the sum of the amounts set forth in clause (a) and clause
     (b). Development Parcel Rent shall be due and payable from the Date of
     Lease Execution (June 1, 1992) until the commencement of Adjusted Rent.
     (For an example, see Section 4.1.6.)

     HOLDING PARCEL RENT: (a) $1.00 multiplied by the number of total square
     feet of land area included within that portion of the Holding Parcel
     exclusive of the Inaccessible Parcel which have been improved and upon
     which parking facilities have been constructed, as more fully provided in
     Section 4.1.l, PLUS (b) $250.00 annually for each parking space striped on
     that portion of the Holding Parcel exclusive of the Inaccessible Parcel,
     PLUS (c) $.50 multiplied by the number of total square feet of the
     remainder of the land area included within that portion of the Holding
     Parcel exclusive of the Inaccessible Parcel; subject to increase on the
     tenth anniversary of the Date of Lease Execution (June 1, 1992)and every
     five years thereafter by the amount equal to the CPI Escalation multiplied
     by the sum of the amounts set forth in clauses (a), (b) and (c). From and
     after the Development Plan Rent Commencement Date, no Holding Parcel Rent
     shall be payable.

     INACCESSIBLE PARCEL RENT: The product of $2.09 multiplied by the greater of
     (i) 80,000 or (ii) the total square feet of FAR Floor Area of Improvements
     constructed on the Inaccessible Parcel, subject to increase on the tenth
     anniversary of the Date of Lease Execution (June 1, 1992) and every five
     years thereafter by an amount equal to the CPI Escalation multiplied by the
     aforementioned product. From and after the Development

                                        3
<Page>

     Plan Rent Commencement Date, no Inaccessible Parcel Rent shall be payable.

     PREMISES: The land and improvements located on the lot described in
     Appendix A attached to the Existing Lease, which lot consists of the
     Development Parcel and the Holding Parcel (which Holding Parcel includes
     the Inaccessible Parcel) as the same are initially established and
     described in said Appendix A. Effective as of the Development Plan
     Commencement Date, the Inaccessible Parcel shall be deemed to have been
     moved from the Holding Parcel to the Development Parcel. The Holding
     Parcel, exclusive of the Inaccessible Parcel, may be eliminated from the
     Premises by Landlord upon the terms and conditions set forth in this Lease.

     RENT: The sum of all Holding Parcel Rent, Inaccessible Parcel Rent,
     Development Parcel Rent and Adjusted Rent, per annum.

     TERM: From the Date of Lease Execution (June 1, 1992) until the sixty-fifth
     anniversary of such Date."

     2. Section 2.1, Premises. The first sentence of Section 2.1 of the Existing
Lease is hereby deleted in its entirety, and the following text is substituted
therefor:

     "Landlord leases the Premises to Tenant and Tenant leases the Premises from
     Landlord for the Term (unless, with respect to all and/or certain portions
     of the Premises, earlier terminated in accordance with the provisions of
     the Lease), subject to the terms of this Lease and all matters of record
     existing as of the Date of Lease Execution and matters referred to herein,
     to all of which Tenant shall conform."

     3. Section 2.1.1. Development Parcel. Holding Parcel and Inaccessible
Parcel. The text of Section 2.1.1 of the Existing Lease is hereby revised as
follows:

          a.   The first paragraph of Section 2.1.1 is hereby deleted in its
     entirety, and the following text is substituted therefor:

               "The Premises consist of the Development Parcel, the Holding
               Parcel and the Inaccessible Parcel (the initial boundaries of
               which are described on Appendix A)."

                                        4
<Page>

          b.   The second sentence of the second paragraph of Section 2.1.l is
     hereby deleted in its entirety.

          c.   The third and fourth paragraphs of Section 2.1.1 are hereby
     deleted in their entirety.

          d.   The fifth paragraph of Section 2.1.1 shall be revised by adding
     to the last sentence thereof the clause:

               "(exclusive of the Inaccessible Parcel), but Tenant shall be
               permitted to use portions of the Holding Parcel for surface
               parking."

     4.   SECTION 2.1.2. Section 2.1.2 of the Existing Lease is hereby deleted
in its entirety.

     5.   SECTION 2.1.3. Section 2.1.3 of the Existing Lease is hereby deleted
in its entirety, and the following new Section 2.1.3 is substituted therefor:

          "2.1.3 Development of Inaccessible Parcel. Tenant shall be entitled to
     construct Improvements on the Inaccessible Parcel from time to time subject
     to and in accordance with Section 3.2 hereof. Until such time as Tenant
     constructs Improvements on the Inaccessible Parcel, Tenant shall pay
     Inaccessible Parcel Rent with respect to the Inaccessible Parcel calculated
     as if the Inaccessible Parcel were improved with 80,000 square feet of FAR
     Floor Area of Improvements.

          From and after the date that Tenant constructs Improvements on the
     Inaccessible Parcel that contain more than 80,000 square feet of FAR Floor
     Area, Tenant shall pay Inaccessible Parcel Rent with respect to the
     Inaccessible Parcel based upon the actual square footage of FAR Floor Area
     of such Improvements, as if such Improvements had been included in the
     initial Development Parcel. Such Rent shall be subject to such increases
     and adjustments as are then and thereafter applicable to the Improvements
     on the initial Development Parcel."

     6.   SECTION 4.1.1. HOLDING PARCEL RENT. Section 4.1.1 of the Existing
Lease is hereby deleted in its entirety, and the following text is substituted
therefor:

          "4.1.1 HOLDING PARCEL RENT. Holding Parcel Rent will be as set forth
     in Section 1.1, except that Holding Parcel Rent will continue to be paid
     with respect to any land area within public or private right of way
     hereafter established whether or not Landlord retains any fee interest
     therein. As of June 1, 1997, the Holding Parcel Rent computed in accordance
     with $1.1 is equal to $15,652.93 per month. The calculation of Holding
     Parcel Rent as of June 1, 1997 is detailed on Schedule 4.1.1 attached
     hereto."

     7.   SECTION 4.1.1.1, INACCESSIBLE PARCEL RENT. The following text is added
as Section 4.1.1.1 of the Existing Lease following Section 4.1.1 of the
Existing Lease:

                                        5
<Page>

          "4.1.1.1 INACCESSIBLE PARCEL RENT. Inaccessible Parcel Rent will be as
set forth in Section 1.1. As of June 1, 1997, the Inaccessible Parcel Rent
computed in accordance with $1.1 is equal to $13,933.33 per month (or $2.09 x
80,000 =Section 167,200.00 per annum or $13,933.33 per month). "

     8.   SECTION 4.1.2. DEVELOPMENT PARCEL RENT. Section 4.1.2 of the Existing
Lease shall be deleted in its entirety, and the following text shall be
substituted therefor:

     "4.1.2 DEVELOPMENT PARCEL RENT. Development Parcel Rent during the Term
     shall be as set forth in Section 1.1, except that the amount set forth in
     clause (b) described under "Development Parcel Rent" shall not be due and
     payable to Landlord until the Development Plan Rent Commencement Date. The
     amount set forth in clause (b) of Development Parcel Rent shall not be
     reduced for any reason, including, without limitation, the fact that Tenant
     is permitted to develop more than 75% but less than 100% of the FAR Floor
     Area as set forth in the Development Plan (the "DEVELOPMENT PLAN FLOOR
     AREA") or if Tenant is prohibited from developing at least 75% of the
     Development Plan Floor Area and does not terminate the Lease as to the
     Holding Parcel in accordance with the provisions of Section 4.2.1.1(f)
     hereof."

     9.   SECTION 4.2.1.1, DEVELOPMENT OF THE HOLDING PARCEL. The following text
is added as Section 4.2.1.1 of the Existing Lease following Section 4.2.1 of the
Existing Lease:

     "4.2.1.1" DEVELOPMENT OF THE HOLDING PARCEL.

     (a) PRELIMINARY DEVELOPMENT PLAN.

     Notwithstanding any provisions of the Existing Lease to the contrary,
     within sixty (60) days after the date of this Second Amendment (the
     "PRELIMINARY DEVELOPMENT PLAN PERIOD"), Tenant shall present to Landlord
     for its review a preliminary development plan and development timetable for
     the Holding Parcel (the "PRELIMINARY DEVELOPMENT PLAN").

     (b) DEVELOPMENT PLAN.

     During the three (3) months following the Preliminary Development Period
     (which three (3) months, together with the Preliminary Development Plan
     Period, shall be hereinafter referred to as the "Development Plan Period
     "), Landlord and Tenant shall negotiate in good faith the terms of a final
     development plan and development timetable for the Holding Parcel (the
     "DEVELOPMENT PLAN") which is consistent with the approved master plan set
     forth in Appendix F of the Existing Lease and mutually acceptable to
     Landlord and Tenant in each party's sole discretion. The Development Plan
     shall include, without limitation, (i) an agreement of Tenant to grant
     Landlord and its successors, assigns, lessees and/or licensees an exclusive
     access easement, in form and substance satisfactory to Landlord, along the
     westerly boundary of the Holding Parcel from Western Avenue to the
     southerly edge of the Holding Parcel and (ii) an identification of each
     Leasehold Mortgage Parcel (as hereinafter defined) and each Sale-Leaseback
     Parcel (as hereinafter defined).

                                        6
<Page>

     To the extent the parties agree to the terms and conditions of the
     Development Plan, the parties agree to enter into an amendment to the
     Existing Lease, as amended hereby, as necessary and appropriate to reflect
     the terms of the Development Plan.

     Tenant acknowledges that Landlord's ability to enter into an amendment to
     the Lease as aforesaid as well as this Second Amendment is derived from M.
     G. L. Chapter 81A which provides that Landlord must submit to the
     Metropolitan Highway System Advisory Board ("ADVISORY BOARD") before the
     final execution thereof by Landlord all contracts, plans, agreements and
     memoranda of understanding relative to land use plans, air rights, zoning
     restrictions and environmental impacts associated with the development of
     the Holding Parcel (any such agreement is herein referred to as a
     "DEVELOPMENT CONTRACT") for review by the Advisory Board.

     (c) MEPA REVIEW.

     Upon completion of the Development Plan (but in any event no later than
     four (4) months after the expiration of the Development Plan Period),
     Tenant shall file a preliminary environmental impact report (the "PEIR")
     complying with all provisions of the Massachusetts Environmental Policy Act
     and the regulations enacted pursuant thereto (collectively, "MEPA") with
     the Commonwealth of Massachusetts Department of Environmental Affairs or
     any other successor agency ("DEP"). Tenant shall simultaneously provide
     Landlord with a copy of the PEIR.

     Upon Tenant's receipt of comments from DEP, Tenant shall submit a thorough
     response to such comments to DEP as soon as practicable (but in any event
     no later than two (2) months after receipt of such comments), and shall
     simultaneously provide Landlord with a copy of such response.

     Within twelve (12) months after the Development Plan Period, Tenant shall
     have complied with the provisions of the Massachusetts Environmental Policy
     Act and the regulations enacted pursuant thereto (collectively, "MEPA") and
     shall have received all permits and/or approvals required thereunder.

     Such twelve-month period shall be extended for up to an additional four (4)
     months if Tenant is diligently and continuously pursuing all applicable
     MEPA permits and/or approvals.

                                        7
<Page>

     (d) DEVELOPMENT PLAN RENT COMMENCEMENT DATE. Tenant shall pay Rent in the
     amount set forth in clause (b) of Development Parcel Rent commencing on the
     earlier of (i) the date on which a permit (or other successor
     permission) entitling Tenant to have temporary or permanent occupancy of
     such Improvements, or portions thereof, is issued or Available To Be Issued
     (hereafter defined) by the City of Boston or when Tenant commences
     occupancy of such Improvements in connection with its business, if earlier
     (Tenant shall give prompt notice of said permit issuance to Landlord), or
     (ii) the date which is eighteen (18) months after all MEPA permits and/or
     approvals have been obtained (but in any event not longer than thirty-four
     (34) months after the expiration of the Development Plan Period) [which
     earlier date shall hereinafter be referred to as the "DEVELOPMENT PLAN RENT
     COMMENCEMENT DATE"].

     "AVAILABLE TO BE ISSUED" shall mean that, but for delays neither caused by
     Tenant nor reasonably preventable by Tenant, could then have been
     substantially completed such that a permit entitling Tenant to have
     temporary or permanent occupancy would be issued.

     (e) LANDLORD'S TERMINATION OPTION. Notwithstanding any provisions of the
     Existing Lease to the contrary, if Tenant fails to comply with any of the
     provisions of subparagraphs (a), (b) and (c) above of this Section 4.2.1.1,
     upon four (4) months prior written notice to Tenant, Landlord may terminate
     the Lease as to the Holding Parcel (exclusive of the Inaccessible Parcel)
     and/or negotiate and conclude a lease transaction regarding all or a
     portion of the Holding Parcel (exclusive of the Inaccessible Parcel) with
     any other potential developers for any development on any terms and
     conditions acceptable to Landlord in its sole discretion. Landlord shall
     use reasonable efforts to require that the lease agreement embodying any
     such lease transaction contain covenants by the lessee to review the scope
     of the lessee's proposed construction with Tenant, to consider the
     coordination of such construction with Tenant, and to provide Tenant with
     the opportunity to comment on the lessee's proposed construction schedule.
     On or before the termination date specified in Landlord's notice to Tenant,
     Tenant shall surrender the Holding Parcel (exclusive of the Inaccessible
     Parcel) to Landlord in accordance with the provisions of the Lease,
     including, without limitation, Section 5.1.9 thereof.

     (f) TENANT'S TERMINATION OPTION. If for whatever reason prior to the
     commencement of the construction of the Improvements described in the
     Development Plan mutually agreed to by the parties Tenant is prohibited
     from developing at least 75% of the Development Plan Floor Area, upon at
     least four (4) months prior written notice to Landlord (which notice must
     be given within sixty (60) days of the date Tenant determines it is unable
     to develop at least 75% of the Development Plan Floor Area), Tenant may
     terminate the Lease as to the Holding Parcel (exclusive of the Inaccessible
     Parcel). On or before the

                                        8
<Page>

     termination date specified in Tenant's notice to Landlord, Tenant shall
     surrender the Holding Parcel (exclusive of the Inaccessible Parcel) to
     Landlord in accordance with the provisions of the Lease, including, without
     limitation, Section 5.1.9 thereof."

     10.  SECTION 4.1.3, CPI ESCALATION. The first sentence of Section 4.1.3 of
the Existing Lease is hereby deleted in its entirety, and the following text is
substituted therefor:

          "The term "CPI Escalation" shall mean the sum from time to time of
          each five successive years' percentage increase in the CPI commencing
          in the case of the initial five Lease Years with CPI with a period
          which includes the Date of Lease Execution (June 1, 1992), and for
          each subsequent five Lease Years commencing with CPI for each
          subsequent five year anniversary of the Date of the Lease Execution
          (June 1, 1992), but no percentage increase shall be included to the
          extent that such increase in CPI exceeds 5% per annum for such period
          and if there is no percentage increase in CPI or a percentage increase
          in CPI of less than 3% per annum for such period, then for the
          purposes of calculating "CPI Escalation" 3% shall be included as the
          annual percentage increase for such period. Notwithstanding any
          provisions of the Existing Lease, as amended hereby, to the contrary,
          the parties hereby acknowledge and agree that the CPI Escalation for
          the initial five Lease Years is 16.1%."

     The last sentence of Section 4.1.3 of the Existing Lease is hereby deleted
in its entirety, and the following text shall be substituted therefor:

          "Accordingly, the CPI escalation for Lease Years l-5 is 23.03% (4% +
          4.16% + 4.87% + 5% (because 5.65% exceeds the 5% cap) + 5% (because
          5.93% exceeds the 5% cap))."

     11.  SECTION 4.1.4. ADJUSTED RENT. Section 4.1.4 of the Existing Lease is
hereby deleted in its entirety, and the following text is substituted therefor:

          "4.1.4 ADJUSTED RENT. Adjusted Rent during the Term shall be set forth
          in Section 1.1 and shall be determined respectively for the 30th,
          40th, 50th and 60th anniversaries of the Date of the Lease Execution
          (June 1, 1992) respectively and, as so determined, remain in effect
          until the next such anniversary (or, finally, the end of the Term)."

     12.  SECTION 4.1.6. EXAMPLES.

          (a) Section 4.1.6(l) of the Existing Lease is hereby deleted in its
          entirety, and the following text is substituted therefor:

                                       9
<Page>

          "(1) Assume it is the beginning of the seventh Lease Year. Tenant has
          built 130,490 sq. ft. of FAR Floor Area of initial Improvements on the
          Premises, the Development Plan Rent Commencement Date has occurred,
          and neither Landlord nor Tenant has terminated this Lease with respect
          to the Holding Parcel (exclusive of the Inaccessible Parcel) as
          provided herein. As of the date of the Development Plan Rent
          Commencement Date, Holding Parcel Rent and Inaccessible Parcel Rent
          will be $1,283,599.53 (90% of the sum of $272,724.10 ($2.09 x
          130,490), plus $1,153,497.60 ($1.86 x 620,160))."

          (b) Section 4.1.6(2) of the Existing Lease is hereby deleted in its
          entirety, and the following text is substituted therefor:

          "(2) Assume it is the thirtieth anniversary of the Date of Lease
          Execution (June 1, 1992); neither Landlord nor Tenant terminated this
          Lease respect to the Holding Parcel (exclusive of the Inaccessible
          Parcel); the Premises are not fully developed as there are 630,490
          square feet (as opposed to 750,650 square feet) of FAR Floor Area of
          Improvements on the Premises. The initial Improvements were 130,490
          square feet of FAR Floor Area and 500,000 square feet of FAR Floor
          Area of Improvements were constructed. Adjusted Rent is to be
          determined in accordance with Section 1.l. Fair Market Value Rent
          (assuming Maximum FAR Floor Area of Improvements is constructed on the
          Premises), in accordance with the procedure set forth in 4. Section
          1.5, has been determined to be $3,500,000 a sum which is greater than
          the amount of Rent paid by Tenant with respect to the previous Lease
          Therefore, in determining Adjusted Rent, Tenant shall pay the lesser
          of Fair market Value Rent or the product of clause (ii) of the
          Adjusted Rent Formula set forth in Section 1.1 which is the sum of the
          products obtained under clause (A) and clause (B) of the Adjusted Rent
          formula set forth in Section 1.1 each respectively increased by 5% per
          annum, cumulatively, from the Date of Lease Execution (June 1, 1992)
          until the beginning of the thirty-first Lease Year or the sum of
          $587,205.00 [$1.80 (1 + (30)(.05)) x 130,490], plus the sum of
          $2,480,640.00 [$1.60 (1 + (30)(.05)) x 620,160] resulting in a sum of
          $3,067,845.00 ($587,205.00 + $2,480,40.00)."

     13.  SECTION 12.1, TENANT'S RIGHT TO MORTGAGE. Section 12.1 of the Existing
Lease is hereby deleted in its entirety, and the following text is substituted
therefor:

     "12.1 RIGHT TO MORTGAGE.

     (a)  Tenant shall have the right from time to time to grant one or more
     separate leasehold mortgages encumbering all or any functionally distinct
     portion of the Premises and the Improvements located thereon (each such
     portion of the Premises so mortgaged, a "LEASEHOLD MORTGAGE PARCEL"),
     assign and lease back all or a portion of the Premises and the Improvements
     located thereon incidental to a so-called sale-leaseback financing (each
     such portion of the Premises subject to a so-called sale-leaseback
     financing, a "SALE-LEASEBACK PARCEL") and grant a security interest under
     the Uniform Commercial Code in all or a portion of its interest in the
     Premises and all or a portion of the Improvements

                                       10
<Page>

     (each a "LEASEHOLD MORTGAGE" and collectively, the "LEASEHOLD MORTGAGES"),
     to secure the payment of any loan or loans obtained by Tenant from one or
     more recognized institutional lenders or other recognized financing sources
     (collectively, "LEASEHOLD MORTGAGEE"); provided, however, that Tenant shall
     give prior written notice to Landlord of its intent to exercise such rights
     hereunder, including in such notice the name, address of each such proposed
     Leasehold Mortgagee, the amount of such loan or loans and a description of
     the Leasehold Mortgage Parcel or the Sale-Leaseback Parcel, as the case may
     be, and thereafter promptly furnish any other information regarding each
     such Leasehold Mortgagee which Landlord may reasonably request. The intent
     of this provision is to enable Tenant to separately finance those
     Improvements on the Premises used principally for manufacturing purposes,
     for office and administrative purposes, and for research and development
     purposes, and for parking facilities. The Leasehold Mortgage having the
     first priority from time to time with respect to each Leasehold Mortgage
     Parcel is the "FIRST LEASEHOLD MORTGAGE" with respect to that respective
     Leasehold Mortgage Parcel; and the holder thereof is the "FIRST LEASEHOLD
     MORTGAGE" with respect to that respective Leasehold Mortgage Parcel. All
     Leasehold Mortgages are sometimes referred to as "PERMITTED FINANCING."

     (b)  Landlord agrees to consider amendments to this Lease which may be
     reasonably required to enable Tenant to obtain separate financing for each
     functionally distinct portion of the Premises. Tenant will submit such
     amendments to Landlord who will review the same and indicate those that are
     acceptable, and as to those which are not, specifying the reasons therefor
     and what changes would make the same acceptable to Landlord. To the extent
     such functionally distinct portion of the Premises is identified on the
     Development Plan, Landlord shall not deem such amendment unacceptable
     provided such amendment otherwise complies with this Section 12.1. At
     Tenant's request, Landlord will enter into separate (i.e., non-cross
     default) ground leases for each functionally distinct portion of the
     Premises, such separate ground leases to be on the same terms as contained
     in this Lease with only such changes as are necessary to accommodate
     separate leasing. In addition to the written notice from Tenant required in
     accordance with paragraph (a), Tenant shall deliver to Landlord a new lease
     upon the same terms and conditions of the Existing Lease as amended hereby,
     covering the Leasehold Mortgage Parcel or the Sale-Leaseback Parcel, as the
     case may be (except to the extent any such terms and conditions do not
     apply to the respective Leasehold Mortgage Parcel or the Sale-Leaseback
     Parcel), and a notice or memorandum thereof, in form and substance suitable
     for recording with the Suffolk County Registry of Deeds and the Suffolk
     Registry District of the Land Court (each a "PERMITTED FINANCING LEASE").
     Landlord shall use reasonable efforts to obtain approval, execute and
     deliver the Permitted Financing Lease as soon as reasonably practicable
     thereafter. Landlord and Tenant agree to negotiate in good faith, execute
     and deliver all other documents, instruments, amendments, restatements,
     agreements and contracts reasonably necessary in connection with the
     execution and delivery of the Permitted Financing Lease, including, but not
     limited to any Landlord Consent, Waiver and Estoppel Agreement by and among
     Landlord, Tenant and Leasehold Mortgagee, reasonably requested by such
     Leasehold Mortgagee.

     (c)  Notwithstanding any provisions of this Lease to the contrary: (i) the
     configuration of any and all Leasehold Mortgage Parcels and/or any and all
     Sale-Leaseback Parcels shall

                                       11
<Page>

     be documented in the Development Plan; (ii) Landlord shall not be required
     to enter into any amendments to this Lease, any Permitted Financing Lease
     or any other documents in connection therewith (collectively, the
     "PERMITTED FINANCING LEASE DOCUMENTS") in order to assist Tenant in
     financing any portion of the Improvements if Landlord is required to pay
     any out-of-pocket expenses in connection therewith and/or if any provisions
     of any such Permitted Financing Lease Document in any way increase
     Landlord's obligations or decrease the economic benefits derived by
     Landlord hereunder; and (iii) Tenant shall promptly (but not later than ten
     (10) days after Landlord's delivery to Tenant of a statement of such costs)
     reimburse Landlord for all actual costs (out-of-pocket and otherwise)
     expended or incurred by Landlord in connection with assisting Tenant in
     arranging financing for any portion of the Improvements, including, without
     limitation, the negotiation and review of any Permitted Financing Lease
     Documents.

     14.  ADJOINING PARCELS. Tenant hereby relinquishes all of its rights in and
to the Adjoining Parcels. In that regard, Article XIV and Appendix C of the
Existing Lease are hereby deleted in their entirety.

     15.  ENTIRE AGREEMENT. This Second Amendment constitutes the entire
agreement between Landlord and Tenant regarding the subject matter hereof and
supersedes all oral statements and prior writings thereto, including, without
limitation, that certain letter dated as of June 18, 1997 from Landlord to
Tenant. Except for those set forth in this Second Amendment, no representations,
warranties, or agreements have been made by Landlord or Tenant to the other with
respect to this Second Amendment or the obligations of Landlord or Tenant in
connection herewith.

     16.  NO OFFER. Submission of this Second Amendment to Tenant shall not be
construed as an offer, and Tenant shall not have any rights under this Second
Amendment unless Landlord executes a copy of this Second Amendment and delivers
it to Tenant.

     17.  LANDLORD FEES. Within ten (10) days after Landlord's delivery to
Tenant of a statement of such costs, Tenant shall reimburse Landlord for fifty
percent (50%) of all costs (including, without limitation, reasonable attorneys'
fees) expended or incurred by Landlord in connection with the drafting and
negotiating of this Second Amendment.

     18.  MISCELLANEOUS. The parties hereto acknowledge and agree that, except
as specifically amended by the terms of this Second Amendment, all of the terms,
covenants and provisions of the Existing Lease are hereby ratified and confirmed
and shall remain in full force and effect throughout the balance of the Term as
defined in this Second Amendment. From and after the date hereof, all references
in the Existing Lease to the terms "the Lease" or "this Lease" shall mean and be
the Existing Lease as affected by this Second Amendment.

                                       12
<Page>

     IN WITNESS WHEREOF, Landlord, Tenant and Guarantor have caused this Second
Amendment to Lease to be executed by their duly authorized representatives as a
Massachusetts instrument under seal on the date and year first above written.

                                        LANDLORD:
APPROVED:                               MASSACHUSETTS TURNPIKE AUTHORITY
MASSACHUSETTS TURNPIKE AUTHORITY

   /s/ Robert M. Ruzzo                  By:   /s/ James E. Rooney
-----------------------------              ---------------------------------
Name: Robert M. Ruzzo,                        Name: James E. Rooney,
      General Counsel                         Title: Chief Financial Officer

                                        TENANT:

                                        ALLSTON LANDING LIMITED
                                        PARTNERSHIP

                                        By: Allston Landing Corporation
                                        Its Sole General Partner

                                        By:   /s/ David J. McLachlan
-----------------------------              ----------------------------------
Name:                                         Name:  David J. McLachlan,
                                              Title: Executive Vice President

                                        GUARANTOR:

                                        GENZYME CORPORATION

                                        By:   /s/ David J. McLachlan
                                           ---------------------------------
                                              Name:  David J. McLachlan
                                              Title: Executive Vice President

                                       13
<Page>

                                 SCHEDULE 4.1.1

             HOLDING PARCEL (PROPER) RENT CALCULATION (AS OF 6/1/97)

The area of the Holding Parcel (excluding the area of the Inaccessible Parcel)
is:  185,598 s.f.

Of the total area, the Landlord has determined the following areas to be
improved land used for access and parking:

<Table>
              <S>                               <C>
              Main parking lot:                 54,608 s.f.
              New parking:                       2,560 s.f.
              Access road to parking:           16,640 s.f.

              TOTAL PARKING:                    73,808 s.f.
</Table>

The unimproved area of the Holding Parcel is:

                         185,598 - 73,808 = 111,790 s.f.

Base rent has been computed at $0.50 (before escalation) for the unimproved area
of the Holding Parcel, and base rent has been computed at $1.00 (before
escalation) for the improved land. In addition, there is a parking fee of
$1.00/day (before escalation) for every working day (261 weekdays, less 11
holidays = 250 days), on the 149 spaces which are on the improved land.

<Table>
<Caption>
                                                                                        WITH EXCEPTION OF
                                                                                        PARKING FEE, ESCALATED
                                               ORIGINAL                                 BY 16.1%
                                               --------                                 ----------------------
<S>                                 <C>                                                 <C>
Improved land rent =                73,808 s. f. x $1.00 =$73,808                       $  85,691.09

Unimproved land rent =              111,790 s. f. x $0.50 =$55,895                      $  64,894.10

Parking fee =                       149 SPACES X 250 DAYS X $1/DAY = $37,250            $  37.250.00
                                    ----------------------------------------            ------------

Holding Parcel Proper Total =               $ 166,953                                   $ 187,835.19

                                                                        DIVIDED BY 12 = $  15,652.93
</Table>

* The CPI Escalation for Lease Years l-5 is 16.1%.

                                       14

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