Document:

exv10w50

Exhibit 10.50

SECURITY AGREEMENT

	 	 	 	 	 
	Name and Address of Grantor:	 	 
	 

	 	Aristos Pharmaceuticals, Inc.	 	 
	 

	 	2000 Regency Parkway, Suite 255	 	 
	 

	 	Cary, NC 27518	 	 
	 
	 	 	 	 
	Name and Address of Debtor:	 	 
	 

	 	Cornerstone Biopharma Holdings, Inc.	 	 
	 

	 	2000 Regency Parkway, Suite 255	 	 
	 

	 	Cary, NC 27518	 	 
	 
	 	 	 	 
	Name and Address of Secured Party:	 	 
	 

	 	Paragon Commercial Bank	 	 
	 

	 	3535 Glenwood Avenue	 	 
	 

	 	Raleigh, NC 27612	 	 
	 

	 	Attn: Brian K. Reid, Senior Vice President	 	 

          THIS
SECURITY AGREEMENT is made and entered into this
25th
day of June, 2008, by
and among Aristos Pharmaceuticals, Inc. (hereinafter called the “Grantor” whether one or more in
number, a corporation, partnership, another legal entity or an individual), whose address is 2000
Regency Parkway, Suite 255, Cary NC 27518, and Cornerstone Biopharma Holdings, Inc. (hereafter
called the “Debtor”), whose address is 2000 Regency Parkway, Suite 255, Cary NC 27518 and Paragon
Commercial Bank (hereinafter called the “Secured Party”), a North Carolina banking Corporation,
whose address is 3535 Glenwood Avenue, Raleigh, NC 27612.

     WHEREAS, Cornerstone Biopharma Holdings, Inc. are indebted to Secured Party in the amount of
Four Million and 00/100 Dollars ($4,000,000.00) as evidenced by its note dated April 21, 2005; and

     WHEREAS, Aristos Pharmaceuticals, Inc. is desirous of securing said Note for the benefit of
Cornerstone Biopharma Holdings, Inc. with UCC filings (Secretary of State) on its properties
located at 2000 Regency Parkway, Suite 255, Cary NC 27518 (the “Property”).

     NOW, THEREFORE, in consideration of Ten Dollars ($10.00), the mutual covenants and promises
contained herein, and other good and valuable consideration, the receipt and sufficiency of which
is hereby acknowledged, Aristos Pharmaceuticals, Inc. hereby agree to pledge their interest in the
Property and related furnishings and equipment as security for the Note as follows:

     (1) CREATION OF SECURITY INTEREST: Grantor and Debtor grants to Secured Party a security
interest in the Collateral described or referred to herein to secure the performance of all direct,
contingent, present and future obligations of Debtor to Secured Party (the “Obligations”).

(2) COLLATERAL: The Collateral is classified generally as:

þ Accounts. Any and all accounts, accounts receivable, receivables, contract rights, book debts,
checks, notes, drafts, instruments, chattel paper, acceptances, choses in action, any and all
amounts due to Debtor from a factor or other forms of obligations and receivables now existing or
hereafter arising out of the business of the Debtor, as well as any and all returned, refused and
repossessed goods, and the cash or non-cash proceeds resulting therefrom.

þ
Inventory. Any and all of Debtor’s inventory, including without limitation any and all goods
held for sale or lease or being processed for sale or lease in Debtor’s business as now or
hereafter conducted, whether now owned or hereinafter acquired, including all materials, goods and
work in process, finished goods, and other tangible property held for sale or lease or furnished or
to be furnished under contracts of service or used or consumed in Debtor’s business, along with all
documents (including documents of title) covering inventory and all cash and non-cash proceeds
from the sale of inventory, including proceeds from insurance.

þ Equipment. Any and all of Debtor’s furnishings and equipment, wherever located, whether now
owned or hereafter acquired, together with all increases, parts, fittings, accessories, equipment,
and special tools now or hereafter affixed to any part thereof or used in connection therewith, and
all products, additions, substitutions, accessions, and all cash and non-cash proceeds, including
proceeds from insurance thereof and thereto.

o Fixtures. All of Debtor’s fixtures now existing or hereafter acquired, together with all
substitutes and replacements therefor, all accessions and attachments thereto, and all tools, parts
and equipment now or hereafter added to or used in connection therewith. These goods are or will
become fixtures on the following described real estate in            County,           (State), owned by
[name of owner] more particularly described as follows:

þ Instruments and/or Investment Documents. The following described instruments and documents
including, without limitation, negotiable instruments, promissory notes, and documents of title
owned or to be owned by Debtor, certificates of deposit, and all liens, security agreements, leases
and other contracts securing or otherwise relating to any of such instruments or documents, and all
cash and non-cash proceeds and products thereof and such additional property receivable or
distributed in respect of or in exchange for all or any of such instruments or documents.

þ General Intangibles. All patents, trademarks, service marks, trade secrets, copyrights and
exclusive licenses (whether issued or pending) and all documents, applications, materials and other
matters related thereto, all inventions, and all manufacturing, engineering and production plans,
drawings, specifications, processes and systems, all trade names, computer programs, databases,
systems and software (including source and object codes), goodwill, choses in action and all other
general intangibles of Debtor whether now owned or hereafter acquired and all cash and non-cash
proceeds thereof.

o Timber. All of Debtor’s uncut timber growing or to be grown on the following described
property, and all cash and non-cash proceeds including proceeds from insurance, and all products
thereof (property description):

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þ Other — Description of Collateral listed in box below:

Description
of Collateral

     A blanket first priority lien on all furnishings, equipment, inventory and other items and
types of personal property now owned or hereafter acquired, all the company’s general intangibles
and accounts receivable, whether presently existing or arising in the future, and all the proceeds
and products from the foregoing (including insurance proceeds) for Aristos Pharmaceuticals, Inc.

     In addition to the foregoing, the collateral shall also include those items listed on Schedule
A, attached hereto and incorporated herein by reference.

Check here o if Debtor has no place of business in North Carolina but resides in North Carolina.
Check here o if Debtor has more
than one place of business in North Carolina. Check here
þ if Debtor
has only one place of business in North Carolina, give county of business here: WAKE.

If checked here o the Collateral described above includes all after-acquired Consumer Goods acquired
by the Debtor within ten (10) days after the Secured Party has given value pursuant to this
Agreement.

If checked here o this is a purchase money security agreement.

          Any additional Collateral acquired hereafter by the Grantor shall be Collateral subject to
this Agreement. All Collateral now or hereafter subject to this Agreement includes the proceeds
thereof and any additions and accessions thereto. Nothing contained herein shall be deemed consent
to the sale of any Collateral.

	(3)	 	GRANTOR’S UNDERTAKINGS: The Grantor agrees:

     (A) that Grantor will protect and properly care for the Collateral and no Collateral will be
misused, wasted or allowed to deteriorate except for normal wear and tear;

     (B) to use the Collateral principally within the State of North Carolina and not to affix the
Collateral to other personal property (unless other provision regarding the location or affixation
of the Collateral is noted herein) and not to affix the Collateral to real property unless it is
classified as a fixture hereinabove and the requisite information is supplied;

     (C) that Secured Party may act as attorney for Grantor in adjusting and canceling any such
insurance coverage and in endorsing any insurance draft and may retain for the satisfaction of the
Grantor’s Obligations any insurance proceeds and/or unearned premium on such insurance;

     (D) that upon the request of Secured Party, Grantor will (i) provide an updated appraisal of
the Collateral and (ii) give to or deposit with Secured Party additional Collateral to Secured
Party’s satisfaction;

     (E) that Collateral will not be changed, transferred, or otherwise disposed of (except for
sale of inventory in the ordinary course of Debtor’s business) or be subjected to any unpaid
charge, unless the Secured Party consents in advance in writing to such change, transfer or charge;

     (F) to procure or execute any Financing Statement or other document and do any act or pay any
costs which Secured Party deems necessary to protect or perfect its security interest under this
Agreement;

     (G) that the Collateral will not be used for illegal purposes; and

     (H) that Secured Party
shall have the right to examine and inspect the Collateral and the books and records relating
thereto, if any, at any reasonable time and, upon demand, Grantor shall assemble the Collateral at
such place or places as Secured Party may designate for the purpose of allowing Bank to examine
same.

	(4)	 	DEFAULT AND REMEDIES:

     (A) The happening of any of the following events shall constitute a default under this
Agreement: (i) the occurrence of a default under any note or other agreement secured hereby; (ii)
the failure of Grantor to perform any of the terms, stipulations and conditions written into this
Agreement; (iii) the insolvency of the Debtor, or the application for the appointment of a receiver
for Debtor, the filing of a petition under any provision of the Bankruptcy Code by or against
Debtor or an assignment for the benefit of creditors by or against Debtor; (iv) the entry of a
judgment against Debtor or the issuance or service of any attachment, levy or garnishment against
Debtor or the Collateral; (v) the failure of Debtor to furnish from time to time at Bank’s request,
financial information with respect to Debtor; (vi) a determination by Bank that the Obligations are
insecure or that a material adverse change in the financial condition of Debtor has occurred since
the date hereof; (vii) failure of Debtor to perform any other agreement with Bank; (viii) any
representation or affirmation by the Debtor to Bank herein or by separate writing is incorrect or
false.

     (B) Upon the occurrence of a default as set forth in (A) above, at the option of Bank, all or
any one of the Obligations secured hereby shall become immediately due and payable without demand
or notice, and Bank shall have at any time after default the rights and remedies provided in the
Uniform Commercial Code as enacted in the State of North Carolina or other applicable law, or by
any note or other agreement secured hereby, and may, without limiting or waiving in any way the
aforesaid rights:

          1. Enter upon Grantor’s premises to take possession of the Collateral or render it unusable,
or require Grantor to assemble the Collateral at any place designated by the Bank reasonably
convenient to both parties;

          2. Give any notice or notification to the Grantor required by the Uniform Commercial Code by
mailing such notice, at least five (5) days before the event, if any, which is the subject of the
notice to the Grantor’s address shown herein. Five (5) days’ notice to Grantor of any proposed
action by Bank shall be deemed reasonable and sufficient notice for all purposes, provided, this
provision shall not require a longer period of notice than shall be reasonable under the
circumstances then existing;

          3. Use the proceeds of the disposition of any Collateral to pay and discharge
all or any of the Obligations of Debtor set forth herein;

          4. Cure the default and the expense of curing such default shall thereupon become part of the
Obligations secured hereby and shall be payable by Debtor to Bank upon demand of Bank, together
with interest thereon at the highest rate allowed by law;

          5. Obtain the appointment of a receiver for all or any part of the Collateral,
without notice to Grantor.

     (A) THIS AGREEMENT IS SUBJECT TO THE TERMS, CONDITIONS, COVENANTS, AGREEMENTS, AFFIRMATIONS
AND STIPULATIONS SET FORTH BELOW, ALL OF WHICH ARE A PART OF THIS AGREEMENT AND BINDING ON THE
PARTIES HERETO; AND

     (B) NO MODIFICATION OR WAIVER OF THE PROVISIONS OF THIS AGREEMENT SHALL BE EFFECTIVE UNLESS IN
WRITING NOR SHALL ANY WAIVER BE APPLICABLE EXCEPT IN THE SPECIFIC INSTANCES FOR WHICH GIVEN.

2

 

          IN WITNESS WHEREOF, this Agreement is executed (i) if by individuals, by hereunto setting
their hands under seal by adoption of the word “SEAL” appearing next to the individuals’ names,
(ii) if by a corporation, by the duly authorized officers of the corporation on its behalf under
seal by adoption of the facsimile seal printed hereon for such purpose or, if an impression seal
appears hereon, by affixing such impression seal, (iii) if by a partnership, by the duly authorized
partners of the partnership on its behalf under seal by adoption of the word “SEAL” appearing next
to the name of the partnership and/or the signatures of the partners, or (iv) if by a limited
liability corporation, by the duly authorized members and/or manager(s) on its behalf under seal by
adoption of the word “SEAL” appearing next to the name of the limited liability corporation and/or
the signatures of the members and/or manager(s), as of the
25th
day of June, 2008.

	 	 	 	 	 	 	 	 	 
	 	 	Aristos Pharmaceuticals, Inc. (SEAL)	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	By:	 	/s/ Craig A. Collard	 	(SEAL)	 	 
	 

	 	 	 	 

Craig A. Collard, CEO
	 		 	 
	 
	 	 	 	 	 	 	 	 
	 	 	Cornerstone Biopharma Holdings, Inc. (SEAL)	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	By:	 	/s/ Craig A. Collard	 	(SEAL)	 	 
	 

	 	 	 	 

Craig A. Collard, President
	 		 	 

	 	 	 	 	 
	Acknowledged By:          Paragon Commercial Bank	 	 
	 
	 	 	 	 
	By:
	 	/s/ Brian K. Reid	 	 
	 

	 	 	 	 
	 

	 	Brian K. Reid, Senior Vice President	 	 

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THE ABOVE AGREEMENT IS SUBJECT TO THE

FOLLOWING ADDITIONAL AGREEMENTS AND AFFIRMATIONS

Collections.

     A. Bank is authorized and empowered at any time in its sole discretion (i) to require Debtor
to notify or itself to notify, either in its own name or in the name of Debtor, all or any of the
account debtors, or any person obligated to Debtor for any amount, that the accounts and/or general
intangibles have been assigned to Bank or to request in its name, in the name of Debtor or in the
name of a third party, confirmation from any such debtor or person of the amount payable or any
other matter stated therein or relating thereto; (ii) to demand, collect or compromise for any and
all sums which are now or may hereafter become due or owing upon any of the accounts or upon any
other obligation to Debtor; (iii) to enforce payment of any account or any other obligation of any
person to Debtor either in its own name or in the name of Debtor; and (iv) to endorse in the name
of Debtor and to collect any instruments tendered or received in payment of the accounts or any of
Debtor’s general intangibles. But Bank under no circumstances shall be under any duty to act in
regard to any of the foregoing matters. The Debtor hereby appoints Bank and any officer or employee
of Bank as Bank may from time to time designate as attorneys-in-fact for the Debtor, to sign and
endorse in the name of Debtor, to give notices in the name of Debtor and to perform all other
actions necessary or desirable in the reasonable discretion of Bank to effect these provisions and
carry out the intent hereof. The Debtor hereby ratifies and approves all acts of such
attorneys-in-fact and neither Bank nor any other such attorneys-in-fact will be liable for any acts
of commission or omission nor for any error of judgment or mistake of fact or law. This power,
being coupled with an interest, is irrevocable so long as any account or general intangible
assigned to Bank remains unpaid and Debtor has any indebtedness to Bank. The costs of such
collection and enforcement, including attorneys’ fees and out-of-pocket expenses, shall be borne
solely by Debtor whether the same are incurred by Bank or Debtor.

     B. At the option of Bank, Debtor will forthwith upon receipt of all checks, drafts, cash and
other remittances in payment or on account of Debtor’s accounts or general intangibles, deposit the
same in a special bank account maintained with Bank, over which Bank has the sole power of
withdrawal and will designate with each such deposit the particular account or general intangible
upon which the remittance was made. The funds in said account shall be held by Bank as security for
the Obligations. Said proceeds shall be deposited in precisely the form received except for the
endorsement of Debtor where necessary to permit collection of items, which endorsement Debtor
agrees to make, and which Bank is also hereby authorized to make on Debtor’s behalf. Pending such
deposit, Debtor agrees that it will not commingle any such checks, drafts, cash and other
remittances with any of Debtor’s funds or property, but will hold them separate and apart therefrom
and upon an express trust for Bank until deposit thereof is made in the special account. Bank may
at any time and from time to time, in its sole discretion, apply any part of the credit balance in
the special account to the payment of all or any of the Obligations, whether or not the same be
due. Upon the full and final liquidation of all of the Obligations, Bank will pay over to the
Debtor any excess received by it from Debtor, whether received by it as a deposit in the special
account or received by it as a direct payment on any of the Obligations.

Other
Agreements and Affirmations of Debtor.

     A. Each and every account or general intangible now owned or hereafter acquired, is a bonafide
existing obligation, valid and enforceable against the account debtor, or other person obligated to
Debtor, and it is not subject to any dispute, defense or offset. Debtor will promptly notify Bank
of any account or general intangible with respect to which the foregoing is untrue.

     B. Debtor will at all times keep accurate and complete records of Debtor’s inventory, accounts
and general intangibles and will upon request furnish Bank a schedule, in form satisfactory to
Bank, describing such accounts, etc. as Bank may require. Debtor will furnish to Bank copies of
contracts and invoices applicable thereto, together with satisfactory evidence of the shipment and
receipt of any goods covered thereby and the performance of any services or obligations covered
thereby as Bank may require if applicable. Bank, or any of its agents, shall have the right to call
at Debtor’s place or places of business at intervals to be determined by Bank and without hindrance
or delay, to inspect Debtor’s inventory and to inspect, audit, check and make extracts from the
books, records, journals, orders, receipts, correspondence and other data relating to Debtor’s
inventory, accounts, general intangibles, or to any other transaction between the parties hereto.

     C. If any of the Debtor’s accounts or general intangibles arise out of contracts with the
United States or any department, agency, or instrumentality thereof, Debtor will immediately notify
Bank in writing and execute any instruments and take any steps required by Bank in order that all
monies due and to become due under such contracts shall be assigned to Bank and notice thereof
given to the Government under the Federal Assignment of Claims Act.

     D. If any of Debtor’s accounts or general intangibles should be evidenced by promissory note,
trade acceptances, or other instruments for the payment of money, Debtor, unless otherwise directed
by Bank will deliver same to Bank within ten days after receipt, appropriately endorsed to Bank’s
order and, regardless of the form of such endorsement, Debtor hereby waives presentment, demand,
notice of dishonor, protest and notice of protest and all other notices with respect thereto. Bank
shall not be bound to take any steps necessary to preserve any right of Debtor against any prior
parties to such instruments which Debtor hereby assumes to do.

     E. Debtor will not without the prior written consent of Bank borrow from anyone except Bank or
pledge, or grant any security interest in, any of its accounts, general intangibles, or any
inventory, equipment, or other property to anyone except Bank, or permit any lien or encumbrance to
attach to any of the foregoing, or any levy to be made thereon, or any financing statement (except
Bank’s statement) to be on file with respect thereto.

     F. Debtor will pay and discharge when due all taxes, levies and other charges on the
Collateral, keep the Collateral insured for the benefit of Bank (to whom loss shall be payable) in
such amounts, in such companies, and against such risks as may be satisfactory to Bank; pay the
cost of all such insurance and deliver certificates evidencing such insurance to Bank; and Debtor
assigns to Bank all rights to receive the proceeds of such insurance, directs any insurer to pay
all proceeds directly to Bank, and authorizes Bank to endorse any draft for such proceeds and to
apply such proceeds against the Obligations in such manner as Bank may determine from time to time.
All insurance policies shall provide for at least ten days prior written notice of cancellation to
Bank.

     G. Debtor agrees that it will not permit any return of merchandise, the sale of which gave
rise to any of the accounts, except in the usual and regular course of business.

     H. Debtor shall give Bank written notice of each office of Debtor in which records of Debtor
pertaining to accounts held as Collateral are kept and each location at which Collateral is or will
be kept, and of any change in any such location. If no such notice is given, all records of Debtor
pertaining to the Collateral are and shall be kept at Debtor’s address shown above, and all
Collateral of Debtor will be kept at Debtor’s address shown above unless otherwise noted as
follows:

Debtor will notify Bank immediately of any material change in the Collateral, or of a change in
Debtor’s residence or location or of the location of any Collateral or of the location of the
records related to any Collateral.

     I. Without the written consent of Bank, Debtor will not change its name, change its corporate
partnership or other legal status, use any tradename or engage in any business in which it was not
engaged on the date of this Agreement.

     J. Notwithstanding anything here in the contrary, the term “Obligations” includes all costs
incurred by Bank to obtain, preserve, perfect, and enforce this Agreement and maintain, preserve,
collect and enforce its rights with respect to the Collateral, including, without limitation, its
reasonable attorneys fees.

     K. Debtor agrees that Bank may sell or assign all or any of the Obligations to a third party
and, in connection therewith, Bank may assign and transfer all of its rights under this Agreement
to such third party who, upon such assignment, shall have all of the rights and benefits granted to
the Bank herein.

4

 

     L. Notwithstanding anything in this Agreement to the contrary, the proceeds from any
disposition of the Collateral shall be applied toward all or any of the following items in such
order as the Bank deems necessary and appropriate: (i) the expenses of taking, removing, storing,
repairing, processing, holding and selling the Collateral, including, without limitation,
reasonable attorney’s fees; (ii) at the Bank’s option, to the expense of liquidating and satisfying
any liens, security interests or encumbrances against the Collateral which may be prior to the
Bank’s security interest; (iii) to the unpaid Obligations. If the proceeds realized from the
disposition of the Collateral shall fail to satisfy all of the foregoing items, Debtor shall be
liable for the remaining deficiency, which shall be payable to Bank on demand. If all of the above
items are paid as a result of the disposition of the Collateral and a surplus exists, the surplus
shall be paid to the persons entitled thereto by law.

     Sale
of Inventory. So long as Debtor is not in default hereunder, Debtor shall have the right,
in the regular course of business, to process and sell Debtor’s inventory. Bank’s security interest
hereunder shall attach to all proceeds of all sales or other dispositions of Debtor’s inventory.

     Term. This Agreement may not be terminated by Debtor while any Obligations remain unpaid, in whole
or in part.

     Financing
Statements. Debtor will deliver such instruments of further assignment or assurance
as Bank may from time to time request to carry out the intent hereof, and will join with Bank in
executing financing statements in form satisfactory to Bank and pay the cost of filing the same and
continuation statements and any other documents in any public office deemed advisable by Bank.
Debtor agrees that a carbon, photographic or other reproduction of this Agreement or a financing
statement shall be sufficient as a financing statement.

     Notification
to Purchasers of Farm Products. If the Collateral is or includes farm products,
as soon as possible, and in any event not less than 15 days prior to any sale of livestock or
crops, the Debtor will provide to the Secured Party a written list of all buyers, commission
merchants, or selling agents (including addresses and phone numbers) to or through whom the Debtor
intends to sell livestock or crops constituting “farm products” under the Food Security Act of 1985
(7 U.S.C. Section 1631, as amended)(the FSA), or applicable state law. The Secured Party is hereby
authorized to give written notice to any person of its security interest, as required or permitted
under the Uniform Commercial Code, the FSA, or other applicable law, which notice may instruct the
recipient to make payments jointly to the Debtor and the Secured Party and may disclose the
Debtor’s social security or taxpayer identification number, together with such other information as
must or may be included for an effective notice under such law. The Debtor agrees to keep the list
on a current basis and not to sell crops or livestock to or through any person not on the list.

5

 

Schedule A

Accounts. Any and all accounts, accounts receivable, receivables, contract rights, book debts,
checks, notes, drafts, instruments, chattel paper, acceptances, choses in action, any and all
amounts due to Debtor from a factor or other forms of obligations and receivables now existing or
hereafter arising out of the business of the Debtor, as well as any and all returned, refused and
repossessed goods, and the cash or non-cash proceeds resulting therefrom.

Inventory. Any and all of Debtor’s inventory, including without limitation any and all goods held
for sale or lease or being processed for sale or lease in Debtor’s business as now or hereafter
conducted, whether now owned or hereafter acquired, including all materials, goods and work in
process, finished goods, and other tangible property held for sale or lease or furnished or to be
furnished under contracts of service or used or consumed in Debtor’s business, along with all
documents (including documents of title) covering inventory and all cash and non-cash proceeds from
the sale of inventory, including proceeds from insurance.

Furniture and Equipment. Any and all of Debtor’s furnishings, fixtures and equipment, wherever
located, whether now owned or hereafter acquired, together with all increases, parts, fittings,
accessories, equipment, and special tools now or hereafter affixed to any part thereof or used in
connection therewith, and all products, additions, substitutions, accessions, and all cash and
non-cash proceeds, including proceeds from insurance thereof and thereto.

Instruments and/or Investment Documents. The following described instruments and documents
including, without limitation, negotiable instruments, promissory notes, and documents of title
owned or to be owned by Debtor, certificates of deposit, and all liens, security agreements, leases
and other contracts securing or otherwise relating to any of such instruments or documents, and all
cash and non-cash proceeds and products thereof and such additional property receivable or
distributed in respect of or in exchange for all or any of such instruments or documents.

General Intangibles. All patents, trademarks, service marks, trade secretes, copyrights and
exclusive licenses (whether issued or pending) and all documents, applications, materials and other
matters related thereto, all inventions, and all manufacturing, engineering and production plans,
drawings, specifications, processes and systems, all trade names, computer programs, databases,
systems and software (including source and object codes), goodwill, choses in action and all other
general intangibles or Debtor whether now owned or hereafter acquired and all cash and non-cash
proceeds thereof.

6exv10w51

Exhibit 10.51

October 29, 2008

David Price, Chief Financial Officer

Cornerstone Biopharma Holdings, Inc.

2000 Regency Parkway Suite 255

Cary, NC 27518

Re:      Financial covenant letter for Cornerstone Biopharma Holdings, Inc.

Dear Mr. Price,

Paragon Commercial Bank (The Bank) approves the following financial covenant modifications
for Cornerstone Biopharma Holdings, Inc.:

	 	I.	 	Craig Collard’s majority ownership (54% — not including Family
Trust ownership) will go to approximately 35% after the merger of Critical
Therapeutics, Inc. and Cornerstone Biopharma Holdings, Inc.

	 	•	 	Craig Collard must maintain Cornerstone Therapeutics, Inc (new
merged entity) as his primary employer and he must hold an executive
management level position (Chairman, CEO, President) in the company
as long as the line of credit is in place.

	 	II.	 	The Bank will allow the Carolina Pharmaceutical subordinated debt
(approximately $8,952,000) to be turned into equity in the new merged entity
and accrued interest (approximately $2,249,077) will be paid out to Carolina
Pharmaceuticals which in turn will be paid to the individual owners.

All other covenants, terms, conditions, collateral and guarantees of the loan will remain the
same.

Please feel free to contact me at my office phone number (919-534-7380) if I can be of
further assistance.

Sincerely,

Brian K. Reid

Senior Vice President

Paragon Commercial Bank

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