Document:

<Page>

                                                                    Exhibit 10.9

                              EMPLOYMENT AGREEMENT
                                 (Alan L. Crane)

     This Employment Agreement (this "Agreement") dated as of March 15, 2002
(the "Effective Date") is made by and between Mimeon, Inc., a Delaware
corporation (the "Company"), and Alan L. Crane ("Employee").

     WHEREAS, Employee has been a director of the Company since June 13, 2001;
and

     WHEREAS, the Company wishes to employ Employee and Employee desires to be
an employee of the Company;

     NOW, THEREFORE, in consideration of the premises and the mutual covenants
and agreements herein contained, the parties hereto agree as follows:

     1.   TITLES AND RESPONSIBILITIES.

          (a)  CHIEF EXECUTIVE OFFICER. The Company hereby employs Employee to
perform those duties and services as the Company shall from time to time set
forth, and Employee accepts employment with the Company, upon the terms and
conditions hereinafter set forth. Employee shall serve as President and Chief
Executive Officer of the Company and shall report to the Board of Directors of
the Company (the "Board"). The Company may elect another individual to serve as
President at some future date, but Employee shall retain the title and
responsibilities of Chief Executive Officer for so long as he is an employee of
the Company.

          (b)  CHAIRMAN OF BOARD OF DIRECTORS. Employee shall serve as a
director and the Chairman of the Board for so long as he is the Chief Executive
Officer or until he earlier resigns as a director or as Chairman.

     2.   DUTY TO PERFORM SERVICES. The Company acknowledges that Employee is
currently an employee of Millennium Pharmaceuticals, Inc. ("Millennium"). During
the period between the Effective Date and June 1, 2002 (the "Transition
Period"), Employee will gradually devote less of his time rendering services to
Millennium and more of his time rendering services to the Company. Commencing on
June 1, 2002, except as provided below, Employee shall devote his full time
during normal business hours to rendering services to the Company hereunder, and
shall exert all reasonable efforts in the rendering of such services. Except to
the extent the restrictions contained in Section 11 may apply, nothing in this
Agreement shall prohibit Employee from (a) making and managing passive
investments, (b) engaging in religious, academic, charitable or other community
or non-profit activities, (c) serving as a non-employee director of Controlled
Delivery Systems, Inc., and (d) serving as a partner of Polaris Venture Partners
("Polaris") in a manner, and to an extent, that will not interfere with his
duties to the Company.

     Employee agrees that in the rendering of all services to the Company and in
all aspects of employment hereunder, he shall comply in all material respects
with all directives, policies, standards and regulations from time to time
established by the Company, to the extent they are not in conflict with this
Agreement.

<Page>

     3.   TERM OF AGREEMENT. The term of this Agreement will commence on the
Effective Date. There shall be no definite term of employment, and Employee
shall be an employee at will. The Company may terminate Employee's employment
with the Company at any time with or without Cause (as defined in
Section 17(e)).

     4.   COMPENSATION.

          (a)  BASE SALARY.

               (i)    TRANSITION PERIOD. For each month during the Transition
Period, the Company will pay Employee a salary equal to $22,950 less the gross
salary paid by Millennium to Employee for such month.

               (ii)   AFTER JUNE 1, 2002. After the Transition Period, the
Company shall pay Employee a base salary, payable in equal installments in
accordance with the Company's standard schedule for salary payments to its
employees, at an annual rate equal to $240,000. Employee's base salary shall be
reviewed by the Compensation Committee of the Board at least once every 12
months, and may be increased on or after each such review as mutually agreed
upon by the Company and Employee.

          (b)  BONUS. By April 15, 2002, the Company shall pay Employee a bonus
of $106,585.

          (c)  RESTRICTED STOCK. Simultaneous with the execution of this
Agreement, the Company shall sell to Employee 766,296 shares (the "Shares") of
the Company's common stock, $.0001 par value per Share, at a price of $.0001 per
Share. The purchase and sale of Shares shall be governed by a Restricted Stock
Purchase Agreement, substantially in the form of Exhibit A, which shall contain,
among other things, a right of the Company to repurchase unvested Shares under
certain circumstances.

     5.   VACATIONS, HOLIDAYS AND SICK TIME; BENEFITS.

          (a)  VACATIONS, HOLIDAYS AND SICK TIME. Employee shall be entitled to
20 paid vacation days annually, and shall not be required to work but shall be
paid for all major U.S. holidays. Employee shall be entitled to the same number
of paid sick days per year as a partner of Polaris is entitled to receive from
Polaris.

          (b)  BENEFITS. Employee and, to the extent applicable, Employee's
family, dependents and beneficiaries, shall be entitled to receive (i) medical,
dental, life and disability insurance coverage through Polaris, the employer
portion of such costs to be borne by the Company, (ii) such other benefits as
may be provided by the Company to its senior executives generally from time to
time, and (iii) such other benefits as may be provided by Polaris to its
partners generally from time to time (collectively, the "Benefits").

                                        2
<Page>

     6.   EXPENSES. The Company shall pay or reimburse Employee for all
reasonable business expenses incurred by Employee in connection with his
employment by the Company in accordance with the Company's policies in effect
from time to time.

     7.   CONFIDENTIAL INFORMATION. While employed by the Company and
thereafter, Employee shall not, directly or indirectly, use any Confidential
Information (as defined below) other than pursuant to his employment by and for
the benefit of the Company, or disclose any Confidential Information to anyone
outside of the Company, whether by private communication, public address,
publication or otherwise, or disclose any Confidential Information to anyone
within the Company who has not been authorized to receive such information,
except as directed in writing by an authorized representative of the Company.
The term "Confidential Information" as used throughout this Agreement shall mean
all trade secrets, proprietary information, and other data or information (and
any tangible evidence, record or representation thereof), whether prepared,
conceived or developed by a consultant or employee of the Company (including
Employee) or received by the Company from an outside source, which is in the
possession of the Company (whether or not the property of the Company), and
which is maintained in confidence by the Company. Without limiting the
generality of the foregoing, Confidential Information shall include:

          (a)  any idea, improvement, invention, innovation, development,
technical data, design, formula, device, pattern, sequence, concept, art,
method, process, machine, manufacturing method, composition of matter, computer
program or software, source code, object code, algorithm, model, diagram, flow
chart, product specification or design, plan for a new or revised product,
sample, compilation of information, or work in process, and any and all
revisions and improvements relating to any of the foregoing (in each case
whether or not reduced to tangible form); and

          (b)  the name of any employee, consultant, customer or prospective
customer, any sales plan, marketing material, plan or survey, business plan or
opportunity, product or development plan or specification, business proposal,
financial record, or business record or other record or information relating to
the present or proposed business of the Company.

     Notwithstanding the foregoing, the term Confidential Information shall not
apply to information which the Company has voluntarily disclosed to the public
without restriction, or which has otherwise lawfully entered the public domain.

     Employee acknowledges that the Company from time to time has in its
possession information which is claimed by customers and others to be
proprietary and which the Company has agreed to keep confidential. Employee
agrees that all such information shall be Confidential Information for purposes
of this Agreement.

     8.   OWNERSHIP AND ASSIGNMENT OF INTELLECTUAL PROPERTY. Employee agrees
that all originals and all copies of materials containing, representing,
evidencing, recording, or constituting any Confidential Information, however and
whenever produced (whether by Employee or others) shall be the sole property of
the Company.

                                        3
<Page>

     Employee agrees that all Confidential Information and all other
discoveries, inventions, ideas, specifications, designs, concepts, research and
other information, processes, products, methods and improvements, or parts
thereof conceived, developed, or otherwise made by him, alone or jointly with
others and in any way relating to the Company's present or proposed products,
programs or services or to tasks assigned to his during the course of his
employment, whether or not patentable or subject to copyright protection and
whether or not reduced to tangible form or reduced to practice, during the
period of his employment with the Company, whether or not made during my regular
working hours, and whether or not made on the Company's premises, and whether or
not disclosed by his to the Company (hereinafter referred to as "Intellectual
Property") together with all products or services which embody or emulate any
Intellectual Property shall belong exclusively to the Company.

     Employee agrees to, and hereby does, assign to the Company all his right,
title and interest throughout the world in and to all Intellectual Property and
to anything tangible which evidences, incorporates, constitutes, represents or
records any Intellectual Property. Employee agrees that all Intellectual
Property shall constitute works made for hire under the copyright laws of the
United States and hereby assigns and, to the extent any such assignment cannot
be made at present, Employee hereby agrees to assign to the Company all
copyrights, patents and other proprietary rights Employee may have in any
Intellectual Property, together with the right to file for and/or own wholly
without restriction United States and foreign patents, trademarks, and
copyrights. Employee agrees to waive, and hereby waives, all moral rights or
proprietary rights in or to any Intellectual Property and, to the extent that
such rights may not be waived, agrees not to assert such rights against the
Company or its licensees, successors or assigns.

     Employee hereby certifies that Schedule A sets forth any and all
confidential information and intellectual property that Employee claims as his
own or otherwise intends to exclude from this Agreement because it was developed
by him prior to the date of this Agreement. Employee understands that after
execution of this Agreement he shall have no right to exclude Confidential
Information or Intellectual Property from this Agreement.

     9.   EMPLOYEE'S OBLIGATION TO KEEP RECORDS. Employee shall make and
maintain adequate and current written records of all Intellectual Property,
including notebooks and invention disclosures, which records shall be available
to and remain the property of the Company at all times. Employee shall disclose
all Intellectual Property promptly, fully and in writing to the Company
immediately upon production or development of the same and at any time upon
request.

     10.  EMPLOYEE'S OBLIGATION TO COOPERATE. Employee will, at any time during
his employment, or after it terminates, upon request of the Company, execute all
documents and perform all lawful acts which the Company considers necessary or
advisable to secure its rights hereunder and to carry out the intent of this
Agreement. Without limiting the generality of the foregoing, Employee will
assist the Company in any reasonable manner to obtain for its own benefit
patents or copyrights in any and all countries with respect to all Intellectual
Property assigned pursuant to Section 8, and Employee will execute, when
requested, patent and other

                                        4
<Page>

applications and assignments thereof to the Company, or Persons (as defined in
Section 17(f)) designated by it, and any other lawful documents deemed necessary
by the Company to carry out the purposes of this Agreement, and Employee will
further assist the Company in every way to enforce any patents and copyrights
obtained, including testifying in any suit or proceeding involving any of said
patents or copyrights or executing any documents deemed necessary by the
Company, all without further consideration than provided for herein. It is
understood that reasonable out-of-pocket expenses of Employee's assistance
incurred at the request of the Company under this Section will be reimbursed by
the Company.

     11.  NONCOMPETITION. Subject to written waivers that may be provided by the
Company upon request, which shall not be unreasonably withheld, Employee agrees
that during the term of this Agreement and for a period of 12 months after the
termination of this Agreement (the "Restricted Period"), Employee shall not
directly or indirectly (i) provide any services in the Field of Interest to any
Person other than the Company, (ii) become an owner, partner, shareholder,
consultant, agent, employee or co-venturer of any Person that has committed, or
intends to commit, significant resources to the Field of Interest.
Notwithstanding the foregoing, Employee may purchase as a passive investment up
to one percent (1%) of any class or series of outstanding voting securities of
any Person that has committed significant resources to the Field of Interest if
such class or series is listed on a national or regional securities exchange or
publicly traded in the "over-the-counter" market.

     12.  NONSOLICITATION. During the Restricted Period, Employee shall not (i)
solicit, encourage, or take any other action which is intended to induce any
employee of, or consultant to, the Company (or any other Person who may have
been employed by, or may have been a consultant to, the Company during the term
of Employee's employment) to terminate his or his employment or relationship
with the Company in order to become employed by or otherwise perform services
for any other Person or (ii) solicit, endeavor to entice away from the Company
or otherwise interfere with the relationship of the Company with any Person who
is, or was within the then-most recent 12 month period, a client or customer of
the Company.

     13.  RETURN OF PROPERTY. Upon termination of Employee's employment with the
Company, or at any other time upon request of the Company, Employee shall return
promptly any Confidential Information, including all customer or prospective
customer lists, other customer or prospective customer information or related
materials, computer programs, software, electronic data, specifications,
drawings, blueprints, medical devices, samples, reproductions, sketches, notes,
notebooks, memoranda, reports, records, proposals, business plans, or copies of
them, other documents or materials, tools, equipment, or other property
belonging to the Company or its customers which Employee may then possess or
have under his control. Employee further agrees that upon termination of his
employment he shall not take with him any documents or data in any form or of
any description containing or pertaining to Confidential Information or
Intellectual Property.

                                        5
<Page>

     14.  OTHER OBLIGATIONS.

          (a)  Employee hereby represents, warrants and agrees (i) that Employee
has the full right to enter into this Agreement and perform the services
required of him hereunder, without any restriction whatsoever; (ii) that in the
course of performing services hereunder, Employee will not violate the terms or
conditions of any agreement between him and any third party or infringe or
wrongfully appropriate any patents, copyrights, trade secrets or other
intellectual property rights of any Person anywhere in the world; (iii) that
Employee has not and will not disclose or use during his employment by the
Company any confidential information that he acquired as a result of any
previous employment or consulting arrangement or under a previous obligation of
confidentiality; and (iv) that Employee has disclosed to the Company in writing
any and all continuing obligations to previous employers or others that require
him not to disclose any information to the Company.

          (b)  Employee acknowledges that the Company from time to time may have
agreements with other Persons, including the government of the United States or
other countries and agencies thereof, which impose obligations or restrictions
on the Company regarding inventions made during the course of work thereunder or
regarding the confidential nature of such work. Employee agrees to be bound by
all such obligations and restrictions and to take all action necessary to
discharge the obligations of the Company thereunder.

     15.  TERMINATION EVENT. The following events shall each be considered a
"Termination Event" and, upon the occurrence of any of them, shall have the
effect of immediately terminating the Company's obligations under this
Agreement, including its obligation to make any further payments hereunder but
excluding the payment of base salary and vacation benefits which are accrued at
the date of termination:

          (a)  Employee's death;

          (b)  Employee's Disability for such period of time and under
circumstances which would constitute a Permanent Disability;

          (c)  The termination of Employee's employment by the Company for Cause
(as defined in Section 17(e)); or

          (d)  The termination of Employee's employment by Employee for any
reason other than Good Reason (as defined in Section 17(e)).

     Any decision to terminate Employee's employment for Cause shall be made by
the Board after Employee has had a reasonable opportunity to be heard by the
Board. Termination pursuant to Section 15(c) shall be without prejudice to any
other right or remedy to which the Company may be entitled, at law, in equity,
under this Agreement or otherwise.

                                        6
<Page>

     Notwithstanding Employee's termination of employment pursuant to Section
15(b), 15(c) or 15(d), Employee's covenants and obligations set forth in
Sections 7, 8, 10, 11, 12 and 13 shall remain in effect and be fully enforceable
in accordance with the provisions thereof.

     16.  TERMINATION WITHOUT CAUSE OR FOR GOOD REASON. In addition to the other
termination rights provided to the Company or Employee hereunder, the Company
may terminate Employee's employment without Cause at any time and Employee may
terminate Employee's employment for Good Reason at any time; PROVIDED, however,
that:

          (a)  Employee's covenants and obligations set forth in Sections 7, 8,
9, 10, 11, 12 and 13 shall remain in effect and be fully enforceable in
accordance with the provisions thereunder; and

          (b)  in the event that Employee's employment is terminated by the
Company without Cause, or by the Employee for Good Reason, at any time prior to
the first anniversary of this Agreement, then, subject to Section 16(d),
Employee shall be entitled to receive (i) the installments of base salary set
forth in Section 4(a) not yet paid to such Employee, payable when and as if
Employee had continued to be employed by the Company until the six-month
anniversary of the date of such termination; and (ii) the Benefits set forth in
Section 5(b) for such period of time; and

          (c)  in the event that Employee's employment is terminated by the
Company without Cause, or by Employee for Good Reason, at any time after the
first anniversary of this Agreement, then, subject to Section 16(d), Employee
shall be entitled to receive (i) the installments of base salary set forth in
Section 4(a) not yet paid to such Employee, payable when and as if Employee had
continued to be employed by the Company the one-year anniversary of the date of
such termination; and (ii) the Benefits set forth in Section 5(b) for such
period of time.

          (d)  Notwithstanding anything to the contrary in Sections 16(b) or
(c), if Employee commences full time employment or enters into a consulting
arrangement with a Person other than the Company (a "New Employer") during the
period of time that the Company would otherwise be providing severance benefits
to Employee pursuant to Sections 16(b) or (c) (the "Severance Period"), then (i)
any cash compensation earned by Employee from a New Employer during the
Severance Period shall be credited toward the Company's severance obligations
under this Section 16, and (ii) the Company shall have no obligation to provide
or pay for any type of Benefits that the New Employer provides to Employee;
provided, that the quality of the benefits provided by the New Employer are
equivalent or superior to the Benefits provided or paid for by the Company.
Employee agrees to inform the Company promptly in writing if he commences
employment or enters into a consulting arrangement with a New Employer while he
is receiving severance payments or Benefits from the Company or Polaris.

     17.  MISCELLANEOUS.

                                        7
<Page>

          (a)  ENTIRE AGREEMENT. This Agreement constitutes the entire agreement
among the parties with respect to the subject matter hereof and supersedes all
other prior agreements and understandings, both written and oral, between the
parties with respect to such subject matter.

          (b)  ASSIGNABILITY, ETC. This Agreement shall be binding upon and
inure to the benefit of the parties hereto and their respective successors and
permitted assigns. This Agreement is not intended to confer upon any Person
other than the parties hereto any rights or remedies hereunder, except as
otherwise expressly provided herein and shall not be assignable by operation of
law or otherwise.

          (c)  AMENDMENTS AND SUPPLEMENTS. This Agreement may not be altered,
changed or amended, except by an instrument in writing signed by the parties
hereto; PROVIDED, HOWEVER, that no such alteration, change or amendment may be
binding on the Company unless approved by the Board.

          (d)  NO WAIVER. The terms and conditions of this Agreement may be
waived only by a written instrument signed by the party waiving compliance. In
the case of the Company, no waiver shall be effective unless approved by the
Board. The failure of any party hereto to enforce at any time any of the
provisions of this Agreement shall in no way be construed to be a waiver of any
such provision, nor in any way to affect the validity of this Agreement or any
part hereof or the right of such party thereafter to enforce each and every such
provision. No waiver of any breach of or non-compliance with this Agreement
shall be held to be a waiver of any other or subsequent breach or
non-compliance.

          (e)  CERTAIN DEFINITIONS. For purposes of this Agreement, the
following terms shall have the meanings set forth below:

          "Cause" means:

               (i)    Employee's dishonesty with respect to the Company;

               (ii)   Employee's misconduct which materially and adversely
reflects upon the business, affairs, operations, or reputation of the Company or
upon Employee's ability to perform his duties for the Company;

               (iii)  Employee's failure to perform his duties and
responsibilities for the Company, which failure continues for more than ten days
after the Company gives written notice to Employee which sets forth in
reasonable detail the nature of such failure;

               (iv)   Employee's negligent performance of his duties, which
negligent performance continues for more than ten days after the Company gives
written notice to Employee which sets forth in reasonable detail the nature of
such negligence; or

                                        8
<Page>

               (v)    Employee's breach of any one or more of the material
provisions of this Agreement, which breach continues for more than ten days
after the Company gives written notice to Employee which sets forth in
reasonable detail the nature of such breach.

          "Disability" means the inability of Employee to substantially perform
his duties to the Company as a result of his incapacity due to illness or
physical disability.

          "Field of Interest" means the field of sequencing, chemical, enzymatic
or biological synthesis, production or modification of linear and branched
sugars and glycoconjugates.

          "Good Reason" means Employee's termination of his employment because
of (i) the Company's breach of any one or more of the material provisions of
this Agreement, which breach continues for more than ten days after Employee
gives written notice to the Company which sets forth in reasonable detail the
nature of such breach; (ii) a material reduction by the Company of Employee's
responsibilities; or (iii) a relocation by the Company of Employee's place of
employment by more than 40 miles.

          "Permanent Disability" means a Disability which continues for at least
120 consecutive calendar days or 150 calendar days during any consecutive
twelve-month period, after its commencement, and is determined in good faith to
be total and permanent by the Board following consultation with reputable
medical or health experts selected by the Board.

          "Person" means an individual, a corporation, an association, a
partnership, an estate, a trust and any other entity or organization.

          (f)  CONSTRUCTION OF AGREEMENT. A reference to a Section or Exhibit
shall mean a Section in or Exhibit to this Agreement unless otherwise expressly
stated. The titles and headings herein are for reference purposes only and shall
not in any manner limit the construction of this Agreement which shall be
considered as a whole. The words "include," "includes" and "including" when used
herein shall be deemed in each case to be followed by the words "without
limitation."

          (g)  NOTICE. All notices and other communications hereunder shall be
in writing and shall be deemed given if delivered by hand, sent by facsimile
transmission with confirmation of receipt, sent via a reputable overnight
courier service with confirmation of receipt requested, or mailed by registered
or certified mail (postage prepaid and return receipt requested) to the parties
at the following addresses (or at such other address for a party as shall be
specified by like notice), and shall be deemed given on the date on which
delivered by hand or otherwise on the date of receipt as confirmed:

     To the Company:

          Mimeon, Inc.
          Bay Colony Corporate Center

                                        9
<Page>

          1000 Winter Street, Suite 3350
          Waltham, MA 02154
          Attention: President

     To Employee:

          Alan L. Crane
          25 Quidnic Road
          Waban, MA 02468

          (h)  GOVERNING LAW. This Agreement shall be governed by, and construed
and enforced in accordance with, the substantive laws of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

          (i)  REMEDIES. Employee recognizes that money damages alone would not
adequately compensate the Company in the event of breach by Employee of this
Agreement, and Employee therefore agrees that, in addition to all other remedies
available to the Company at law, in equity or otherwise, the Company shall be
entitled to injunctive relief for the enforcement hereof. All rights and
remedies hereunder are cumulative and are in addition to and not exclusive of
any other rights and remedies available at law, in equity, by agreement or
otherwise.

          (j)  SURVIVAL; VALIDITY. Except as expressly provided herein, the
provisions of this Agreement shall not survive termination of Employee's
employment by the Company for any reason. In the event that any provision of
this Agreement shall be determined to be unenforceable by reason of its
extension for too great a period of time or over too large a geographic area or
over too great a range of activities, it shall be interpreted to extend only
over the maximum period of time, geographic area or range of activities as to
which it may be enforceable. If, after application of the preceding sentence,
any provision of this Agreement shall be determined to be invalid, illegal or
otherwise unenforceable by a court of competent jurisdiction, the validity,
legality and enforceability of the other provisions of this Agreement shall not
be affected thereby. Except as otherwise provided in this Section 24, any
invalid, illegal or unenforceable provision of this Agreement shall be
severable, and after any such severance, all other provisions hereof shall
remain in full force and effect.

          (k)  COUNTERPARTS. This Agreement may be executed in one or more
counterparts, all of which together shall constitute one and the same Agreement.

* * * * *

                                       10
<Page>

     IN WITNESS WHEREOF, the parties have caused this Employment Agreement to be
executed as an agreement under seal as of the date first written above.

                                  MIMEON, INC.

                                  By: /s/ Christoph Westphal
                                     -------------------------------
                                      Christoph Westphal
                                      President

                                      /s/ Alan L. Crane
                                  ----------------------------------
                                  Alan L. Crane

                                       11<Page>

                                                                   EXHIBIT 10.10

                       RESTRICTED STOCK PURCHASE AGREEMENT
                                 (Alan L. Crane)

     This Restricted Stock Purchase Agreement dated as of June 13, 2001 (this
"Agreement") is made by and between Mimeon, Inc., a Delaware corporation (the
"Company"), and Alan L. Crane (the "Purchaser").

     1.   DEFINITIONS. As used in this Agreement, the following terms shall have
the following meanings:

          QUALIFIED OFFERING: A firm commitment underwritten public offering of
the Company's Common Stock pursuant to an effective registration statement under
the Securities Act of 1933, as amended (the "Act"), in which the price per share
is at least $5.00 (subject to equitable adjustment in the event of stock splits
and the like) and the aggregate gross proceeds to the Company from such offering
are not less than $10,000,000.

          QUALIFIED SALE: The sale of all or substantially all of assets or
issued and outstanding capital stock of the Company, or merger or consolidation
involving the Company in which stockholders of the Company immediately before
such merger or consolidation do not own immediately after such merger or
consolidation capital stock or other equity interests of surviving corporation
or entity representing more than fifty percent in voting power of capital stock
or other equity interests of such surviving corporation or entity outstanding
immediately after such merger or consolidation.

          SERVICE: Service as an employee, officer or director of, or a
consultant or advisor to, the Company or its successors.

          SHARES: The shares of Common Stock issued to Purchaser hereunder and
any other securities of the Company which may be issued in exchange for or in
respect of such shares of Common Stock, whether by way of stock split, stock
dividend, combination of shares, reclassification, recapitalization,
reorganization or any other means.

          UNVESTED SHARES: Any Shares that are not Vested Shares.

          VESTED: Released from the Company's Repurchase Option (as defined in
Section 5(a)).

          VESTED SHARES: Any Shares that have vested in accordance with Section
5(b).

     2.   PURCHASE AND SALE OF SHARES. The Company hereby sells to Purchaser,
and Purchaser hereby purchases from the Company, 23,438 shares of the Company's
common stock, $0.0001 par value per share ("Common Stock"), for a purchase price
per share of $0.0001, and an aggregate purchase price of $2.35. The Company
acknowledges receipt from Purchaser of $2.35 in cash, in full payment of such
purchase price. Purchaser and the Company hereby agree that the fair market
value of the Shares on the date hereof is $0.0001 per share.

<Page>

     3.   REPRESENTATIONS OF PURCHASER. Purchaser understands that the Shares
are not registered under the Act, and represents to the Company, and agrees that
the Company is entitled to rely on such representations, as follows:

          (a)  Purchaser understands that the Shares have not been registered
under the Act, or registered or qualified under the securities or "Blue Sky"
laws of any jurisdiction, and are being sold pursuant to exemptions contained in
the Act and exemptions contained in other applicable securities or "Blue Sky"
laws. Purchaser understands further that the Company's reliance on these
exemptions is based in part on the representations made by Purchaser in the
Agreement. In this connection, Purchaser represents and warrants that the offer
and sale of the Shares were made solely in Massachusetts.

          (b)  Purchaser understands the term "accredited investor" as used in
Regulation D promulgated under the Act and represents and warrants to the
Company that he is an "accredited investor" for purposes of acquiring the
Shares. The nature and amount of Purchaser's investment in the Shares is
consistent with Purchaser's investment objectives, abilities, and resources.
Purchaser understands that the Shares are an illiquid investment, which will not
become freely transferable by reason of any "change of circumstances" whatever.
Purchaser has adequate means of providing for Purchaser's current needs and
possible contingencies and has no need for liquidity in Purchaser's investment.

          (c)  Purchaser is acquiring the Shares for Purchaser's own account for
investment, and not for, with a view to, or in connection with the resale or
distribution thereof. Purchaser has no present intention to sell, hypothecate,
distribute or otherwise transfer the Shares or any portion thereof or any
interest therein.

          (d)  Purchaser understands that the Shares will constitute "restricted
securities" within the meaning of Rule 144 promulgated under the Act and that,
as such, the Shares must be held indefinitely unless they are subsequently
registered under the Act or unless an exemption from the registration
requirements thereof is available. Purchaser has been advised that Rule 144,
which permits the resale, subject to various terms and conditions, of small
amounts of such "restricted securities" after they have been held for one year,
does not now apply to the Company, because the Company is not now required to
file, and does not file, current reports under the Securities Exchange Act of
1934, and because information concerning the Company substantially equivalent to
that which would be available if the Company were required to file such reports
is not now publicly available. The Company may become a reporting entity at some
future date, but no assurance can be given that it will do so.

          (e)  In connection with Purchaser's acquisition of the Shares,
Purchaser accepts the condition that the Company may maintain "stop transfer"
orders with respect to the Shares and that each certificate or other document
evidencing the Shares will bear conspicuous legends in substantially the form
set forth in Section 7 of this Agreement.

          (f)  Purchaser has consulted Purchaser's attorney or accountant with
respect to Purchaser's purchase of the Shares. Purchaser has fully investigated
the Company and its business and financial condition and has knowledge of the
Company's current activities. Purchaser acknowledges that the Company has
granted Purchaser and Purchaser's attorney or

                                        2
<Page>

accountant access to all information about the Company which they have requested
and has offered each of them access to all further information which they deemed
relevant to an investment decision with respect to the Shares. Purchaser and
Purchaser's attorney or accountant have had the opportunity to ask questions of,
and receive answers from, representatives of the Company concerning such
information and the Company's financial condition and prospects.

     4.   RESTRICTIONS ON TRANSFER. The following restrictions on transfer of
the Shares shall apply:

          (a)  SECURITIES LAWS. Except for purchases of Unvested Shares by the
Company as contemplated by Section 5, no Shares, nor any interest therein, may
be sold, assigned, pledged or otherwise transferred at any time or under any
circumstances unless (i) the Shares proposed to be transferred have been
registered under the Act and qualified under applicable state securities laws,
or (ii) the Company has received, or agreed to waive, an opinion of counsel
acceptable to the Company to the effect that such transfer may be effected
without registration under the Act or qualification under the securities laws of
relevant states and the proposed transferee has made such representations and
agreements as the Company shall require to assure compliance with the Act and
such laws.

          (b)  TERMINATION OF REPURCHASE OPTION. Except for purchases of
Unvested Shares by the Company as contemplated by Section 5, no Shares, nor any
interest therein, may be sold, assigned, pledged or otherwise transferred until
the Repurchase Option shall have terminated with respect to such Shares.

          (c)  RIGHT OF FIRST OFFER. In the event that at any time Purchaser
desires to sell, assign or otherwise transfer any of the Vested Shares then held
by Purchaser, he shall first offer the Vested Shares desired to be transferred
to the Company by giving written notice of the proposed transfer. The notice
shall state the number of Vested Shares proposed to be transferred, the name of
the person or persons to whom it is proposed to transfer the Vested Shares, the
price at which the Vested Shares are intended to be transferred and all other
terms of the transaction, which must be bona fide. Such notice shall constitute
an offer by Purchaser to the Company for the Company to purchase such Vested
Shares on such terms and at a price per Vested Share equal to the price stated
in the notice. The Company may accept the offer as to all, but not less than
all, of the Vested Shares offered by notifying Purchaser in writing within 30
days after receipt of such notice of its acceptance of the offer. If the offer
is accepted, Purchaser shall sell the offered Vested Shares to the Company on
the terms and at the price per Vested Share as aforesaid, free of all
encumbrances, and shall deliver the certificates representing such Vested
Shares, duly endorsed in blank by Purchaser or with duly executed stock powers
attached thereto, all in form suitable for the transfer of such Vested Shares to
the Company, within 30 days of the date of acceptance of the offer to sell,
against payment therefor at the same price per Vested Share and according to the
same terms as were offered by the proposed transferee. If within the applicable
time period Purchaser does not receive notice of the Company's intention to
purchase the offered Vested Shares, the offer shall be deemed to have been
rejected. In such event, Purchaser may transfer title to the offered Vested
Shares within 90 days from the date of his written notice to the Company of his
intention to sell, but such transfer shall be made only to the proposed
transferee or transferees and at the proposed price and on such other terms as
stated

                                        3
<Page>

in such notice. Vested Shares that are so transferred to such transferee or
transferees shall remain subject to this Section 3 and as a condition to any
transfer Purchaser shall obtain a written agreement from the transferee by which
the transferee agrees to be bound by this Section 3.

          (d)  PERMITTED TRANSFERS. Any portion or all of the Vested Shares may,
without compliance with the provisions of Section 4(c), be transferred by
Purchaser to a member of his immediate family or to a family partnership or
family trust, or on Purchaser's death may be transferred to Purchaser's estate
or to those entitled to a distribution of the Vested Shares under the laws of
descent and distribution, provided that Shares that are so transferred shall
remain subject to this Section 4 and as a condition to any transfer Purchaser
shall obtain a written agreement from the transferee by which the transferee
agrees to be bound by this Section 4.

          (e)  REMEDIES. No sale, assignment, pledge or other transfer of Shares
shall be effective or given effect on the books of the Company unless all of the
applicable provisions of this Section 4 have been duly complied with. If any
transfer of Shares is made or attempted in violation of the foregoing
restrictions, or if Shares are not offered to the Company as required hereby,
the Company shall have the right to purchase such Shares from the purported
owner thereof or his transferee at any time before or after the transfer, as
herein provided. In addition to any other legal or equitable remedies which it
may have, the Company may enforce its rights by actions for specific performance
(to the extent permitted by law) and may refuse to recognize any transferee as
one of its stockholders for any purpose, including, without limitation, for
purposes of dividend and voting rights, until all applicable provisions hereof
have been complied with.

          (f)  LOCK-UP. Purchaser agrees that for a period of up to 180 days
from the effective date of any registration of securities of the Company (upon
request of the Company or the underwriters managing any underwritten offering of
the Company's securities), he will not sell, make any short sale or loan of,
grant any option for the purchase of, or otherwise dispose of any Shares held by
him without the prior written consent of the Company or such underwriters, as
the case may be.

          (g)  TERMINATION OF RESTRICTIONS. Sections 4(c) and 4(d) shall
terminate upon the earlier to occur of: (i) immediately prior to the
consummation of a Qualified Sale; or (ii) the closing of a Qualified Offering.

     5.   REPURCHASE OF UNVESTED SHARES.

          (a)  REPURCHASE OPTION.

               (i)   In the event of the termination of Purchaser's Service by
Purchaser or the Company for any reason, with or without cause, the Company
shall upon the date of such termination (the "Termination Date") have an
irrevocable, exclusive option (the "Repurchase Option") for a period of 90 days
from such date to repurchase all or any portion of the Unvested Shares at the
per share repurchase price of $0.0001 per share, appropriately adjusted in the
event of a stock dividend, stock split, recapitalization, combination of shares
or similar event occurring subsequent to the date of this Agreement.

                                        4
<Page>

               (ii)  Unless the Company notifies Purchaser within 90 days from
the date of termination of Purchaser's Service that it does not intend to
exercise its Repurchase Option with respect to some or all of the Unvested
Shares, the Repurchase Option shall be deemed automatically exercised by the
Company as of the 90th day following such termination, provided that the Company
may notify Purchaser that it is exercising its Repurchase Option as of a date
prior to such 90th day. Unless Purchaser is otherwise notified by the Company
pursuant to the preceding sentence that the Company does not intend to exercise
its Repurchase Option as to some or all of the Unvested Shares to which it
applies at the time of termination, execution of this Agreement by Purchaser
constitutes written notice to Purchaser of the Company's intention to exercise
its Repurchase Option with respect to all Unvested Shares to which such
Repurchase Option applies. The Company, at its choice, may satisfy its payment
obligation to Purchaser with respect to exercise of the Repurchase Option by
either (A) delivering a check to Purchaser in the amount of the purchase price
for the Unvested Shares being repurchased, or (B) in the event Purchaser is
indebted to the Company, canceling an amount of such indebtedness equal to the
purchase price for the Unvested Shares being repurchased, or (C) by a
combination of (A) and (B) so that the combined payment and cancellation of
indebtedness equals such purchase price, provided that the Company shall use
good faith efforts to satisfy its payment obligation to Purchaser within 15 days
after Company's notice of exercise of the Repurchase Option (or deemed
exercise), and that if such check is not delivered or such cancellation is not
effective within such 15 days from such date, the amount of the Company's
unsatisfied payment obligation shall bear interest at a rate of nine percent
(9%) per annum until the Company has satisfied its payment obligation under this
paragraph (ii). In the event of any deemed automatic exercise of the Repurchase
Option pursuant to this Section 5(a)(ii) and Purchaser is then indebted to the
Company, the amount of such indebtedness equal to the purchase price of the
Unvested Shares being repurchased shall be deemed automatically canceled as of
the date of Company's notice of exercise of the Repurchase Option (or deemed
exercise). As a result of any repurchase of Unvested Shares pursuant to this
Section 5(a), the Company shall become the legal and beneficial owner of the
Unvested Shares being repurchased and shall have all rights and interest therein
or related thereto, and the Company shall have the right to transfer to its own
name the number of Unvested Shares being repurchased by the Company, without
further action by Purchaser.

     (b)  VESTING.

          (i)  The Shares will become vested as follows:

               (A) one sixteenth (1/16) of the Shares shall vest on
September 13, 2001; and

               (B) an additional one sixteenth (1/16) of the Shares shall vest
on the last day of each consecutive three-month period thereafter until 100% of
the Shares have become vested; PROVIDED, however, that the vesting of Shares on
any such vesting date shall be conditioned upon Purchaser's continuing Service
with the Company from the date hereof through such vesting date. Fractional
shares shall be rounded down to the nearest whole share.

                                        5
<Page>

          (ii) Notwithstanding Section 4(b)(i), all Shares shall be deemed to
have vested immediately prior to the consummation of a Qualified Sale.

     6.   CUSTODY OF CERTIFICATES. In order to facilitate the exercise of the
Repurchase Option, the Company or its counsel shall hold all certificates
representing Unvested Shares, together with an adequate number of undated and
otherwise blank stock powers executed by Purchaser. The Company shall have the
right to cause transfers of Unvested Shares to be effected pursuant to Section
5. After any Shares become Vested Shares, the Company shall, upon request of
Purchaser, deliver to Purchaser a certificate or certificates representing such
Vested Shares. After the Company sends Purchaser a notice that it does not
intend to exercise its Repurchase Option as to certain Unvested Shares, the
Company shall, upon request of Purchaser, deliver to Purchaser a certificate or
certificates representing such Unvested Shares.

     7.   LEGENDS. Each certificate representing Shares shall prominently bear
legends in substantially the following forms:

     These securities have not been registered under the Securities Act of 1933.
     They may not be sold, offered for sale, pledged or hypothecated in the
     absence of a registration statement in effect with respect to the
     securities under such Act or an opinion of counsel satisfactory to the
     Corporation that such registration is not required.

     The securities represented by this certificate have been acquired for
     investment and have not been registered or qualified under the securities
     or "Blue Sky" laws of any jurisdiction. They may not be offered or sold
     without an opinion of counsel to the Corporation to the effect that the
     proposed transaction will be exempt from registration, qualification, and
     filings in all applicable jurisdictions.

     The Corporation is authorized to issue more than one class or series of
     stock. The powers, designations, preferences and relative participating,
     optional or other special rights, and the qualifications, limitations or
     restrictions of such preferences and/or rights of each class of stock or
     series of any class set forth in the Certificate of Incorporation of the
     Corporation. The Corporation will furnish a copy of the Certificate of
     Incorporation of the Corporation to the holder of this certificate without
     charge upon request.

     The securities represented by this certificate are subject to restrictions
     on transfer and repurchase rights pursuant to the terms of a Restricted
     Stock Purchase Agreement, as amended from time to time, between the owner
     of this certificate and the Corporation. The Corporation will furnish a
     copy of this agreement to the holder hereof without charge upon written
     request.

     8.   MISCELLANEOUS.

          (a)  ENTIRE AGREEMENT. This Agreement constitutes the entire agreement
between the parties with respect to the subject matter hereof, and supersedes
all prior agreements, negotiations, representations and proposals, written or
oral, relating to such subject matter.

                                        6
<Page>

          (b)  AMENDMENTS. Neither this Agreement nor any provision hereof may
be changed or modified except by an agreement in writing executed by Purchaser
and on behalf of the Company.

          (c)  BINDING EFFECT OF THE AGREEMENT. This Agreement shall inure to
the benefit of, and be binding upon, the Company, Purchaser and their respective
estates, heirs, executors, transferees, successors, assigns and legal
representatives.

          (d)  PROVISIONS SEVERABLE. In the event that any provision of this
Agreement shall be determined to be invalid, illegal or otherwise unenforceable
by any court of competent jurisdiction, the validity, legality and
enforceability of the other provisions of this Agreement shall not be affected
thereby. Any invalid, illegal or unenforceable provision of this Agreement shall
be severed, and after any such severance, all other provisions hereof shall
remain in full force and effect.

          (e)  NOTICES. All notices under this Agreement shall be effective (i)
upon personal or facsimile delivery, (ii) two business days after deposit in the
United States mail as registered or certified mail postage fully prepaid, or
(iii) one business day after pickup by any overnight commercial courier service,
in each case sent or addressed to the Company at its principal office and to
Purchaser at his record address as carried in the stock records of the Company
or at such other address as he may from time to time designate in writing to the
Company.

          (f)  CONSTRUCTION. A reference to a Section shall mean a Section of
this Agreement unless otherwise expressly stated. The titles and headings herein
are for reference purposes only and shall not in any manner limit the
construction of this Agreement which shall be considered as a whole. The words
"include," "includes" and "including" when used herein shall be deemed in each
case to be followed by the words "without limitation." Whenever the context may
require, any pronouns used herein shall include the corresponding masculine,
feminine or neuter forms, and the singular form of names and pronouns shall
include the plural and vice-versa.

          (g)  NO EMPLOYMENT AGREEMENT. This Agreement shall not be construed as
an agreement by the Company to employ Purchaser, nor is the Company obligated to
employ Purchaser by reason of this Agreement or the issuance of the Shares to
Purchaser.

          (h)  SECTION 83(b) ELECTION. Purchaser will furnish to the Company a
copy of any election made by Purchaser under Section 83(b) of the Internal
Revenue Code of 1986, as amended, with respect to his acquisition of the Shares.

          (i)  APPLICABLE LAW. This Agreement shall be construed and enforced in
accordance with the laws of The Commonwealth of Massachusetts, without regard to
its principles of conflicts of laws. Purchaser consents to jurisdiction and
venue in any state or federal court in The Commonwealth of Massachusetts for the
purposes of any action relating to or arising out of this Agreement or any
breach or alleged breach hereof, and to service of process in any such action by
certified or registered mail, return receipt requested.

                                        7
<Page>

          (j)  DISPOSITION OF SHARES; PURCHASE BY NOMINEE OR DESIGNEE. Any
Shares that the Company elects to purchase hereunder may be disposed of by it in
such manner as it deems appropriate with or without restrictions on the transfer
thereof, and the Company may require their transfer to a nominee or designee as
part of any purchase of the Shares from Purchaser.

          (k)  WITHHOLDING TAXES. Purchaser acknowledges and agrees that the
Company has the right to deduct from payments of any kind otherwise due to
Purchaser any federal, state or local taxes of any kind required by law to be
withheld with respect to the purchase of the Shares by Purchaser.

                                        8
<Page>

     IN WITNESS WHEREOF, the parties hereto have executed this Restricted Stock
Purchase Agreement as of the date first above written.

                                   MIMEON, INC.

                                   By: /s/ Ganesh Venkataraman
                                       -----------------------------
                                   Name:
                                   Title

                                   /s/ Alan L. Crane
                                   ----------------------------------
                                           Alan L. Crane

                                       9

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00062-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00062-of-00352.parquet"}]]