Document:

EXHIBIT 10.7

EXECUTION VERSION

 

SECOND OMNIBUS
AMENDMENT AGREEMENT

 

This SECOND OMNIBUS AMENDMENT AGREEMENT (this
“Amendment”), dated as of July 19, 2019 (the “Effective Date”), is entered into by and among
APPLIED DNA SCIENCES, INC., a Delaware corporation (the “Issuer”), APDN (B.V.I.) INC., a corporation
organized under the laws of the British Virgin Islands (the “Guarantor”, and together with the Issuer, collectively,
the “Grantors” and each a “Grantor”), DELAWARE TRUST COMPANY, a Delaware corporation,
as collateral agent (together with its successors and assigns, in such capacity, the “Collateral Agent”) for
the benefit of the Buyers (defined below) and each of the investors listed on Schedule I attached hereto (each, a “Buyer”
and collectively, the “Buyers”; the Buyers and the Collateral Agent are collectively, together with their successors
and assigns, collectively, the “Secured Parties”).

 

WITNESSETH:

 

WHEREAS, the Issuer and the Collateral
Agent are parties to that certain Security Agreement, dated as of October 19, 2018 (as amended to date and as the same may be further
amended, amended and restated, supplemented or otherwise modified from time to time, the “Security Agreement”),
whereby the Issuer granted a security interest in substantially all of its tangible and intangible assets, whether real or personal
property, now or hereafter acquired (the “Issuer Collateral”), to the Collateral Agent for the ratable benefit
of the Secured Parties; and

 

WHEREAS, the Guarantor and the Collateral
Agent are parties to that certain Guaranty and Security Agreement, dated as of October 19, 2018 (as amended, amended and restated,
supplemented or otherwise modified from time to time, the “Guaranty and Security Agreement” and together with
the Security Agreement, collectively, the “Security Agreements”), whereby the Guarantor granted a security interest
in substantially all of its tangible and intangible assets, whether real or personal property, now or hereafter acquired (the “Guarantor
Collateral”, and together with the Issuer Collateral, collectively, the “Collateral”), to the Collateral
Agent for the ratable benefit of the Secured Parties; and

 

WHEREAS, the Collateral Agent, the
Grantors and the investors party thereto as Buyers (the “Original Buyers”; each Buyer party hereto which is
not an Original Buyer is a “New Buyer”) are parties that certain Collateral Agency Agreement, dated as of October
19, 2018 (as amended, amended and restated, supplemented or otherwise modified from time to time, the “Collateral Agency
Agreement”), whereby, among other things, the Original Buyers appointed the Collateral Agent as the Secured Parties’
representative and agent with respect to the Collateral; and

 

WHEREAS, the Grantors and the Secured
Parties have previously amended each of the Security Agreement, the Guaranty and Security Agreement and the Collateral Agency Agreement
pursuant to that certain Omnibus Amendment Agreement, dated as of February 26, 2019; and

 

WHEREAS, the Grantors have requested
and the Secured Parties, by their execution and acknowledgement hereof, have each agreed, subject to the terms of this Amendment,
to further amend each of the Security Agreement, the Guaranty and Security Agreement and the Collateral Agency Agreement (each
a “Transaction Document” and collectively, the “Transaction Documents”), as provided herein.

 

     

     

    

 

NOW, THEREFORE, the parties hereto
hereby agree as follows, for good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged and intending
to be legally bound:

 

1.            Definitions. Capitalized terms used and not otherwise defined in this Amendment shall have the respective
meanings given to such terms in the applicable Transaction Document.

 

2.            Joinder. Each New Buyer hereby becomes a Buyer under the terms of the Collateral Agency Agreement and any
other Transaction Document (as defined in the Collateral Agency Agreement) to which any Buyer is a party (collectively, the “Buyer
Documents”), and appoints the Collateral Agent as provided in Section 1 of the Collateral Agency Agreement. Each New
Buyer agrees that it hereby is, and shall be deemed to be, and assumes the obligations of, a “Buyer” under each of
the Buyer Documents, including the joint and several indemnification obligations in the Collateral Agency Agreement. Each New Buyer
hereby agrees to perform, comply with, and be subject to and bound by each of the terms and provisions of each of the Buyer Documents
jointly and severally with the other Buyers party thereto.

 

3.            Amendment to the Collateral Agency Agreement.

 

(a)              
the first “WHEREAS” clause of the Collateral Agency Agreement is hereby amended and restated, in its
entirety, as follows:

 

“WHEREAS, the Issuer and the Buyers are
parties to (i) that certain Securities Purchase Agreement, dated as of August 31, 2018 (the “August Securities Purchase
Agreement”, (ii) that certain Securities Purchase Agreement, dated as of November 29, 2018, or (iii) that certain Securities
Purchase Agreement, dated as of July 16, 2019 (the “July Securities Purchase Agreement” and, together with the
August Securities Purchase Agreement and the November Securities Purchase Agreement, collectively, the “Securities Purchase
Agreement”), and certain other agreements, documents and instruments executed and delivered in connection therewith (together
the Securities Purchase Agreement and this Agreement, collectively, the “Transaction Documents”), pursuant to
which the Issuer shall be required to sell, and the Buyers shall purchase or have rights to purchase, on a several and not joint
basis, the principal amount of the notes issued pursuant thereto (as such notes may be amended, amended and restated, supplemented
or otherwise modified from time to time, the “Notes”).”

 

(b)              
Section 1(a) of the Collateral Agency Agreement is hereby amended to adding the following sentence at the end of Section
1(a):

 

“The Collateral Agent further
agrees that each Buyer may purchase additional Notes from the Issuer pursuant to an amendment to each Buyer’s Note between
such Buyer and the Company.”

 

     -2-

     

    

 

(c)              
Section 1(a)(iii) of the Collateral Agency Agreement is hereby amended and restated, in its entirety, as follows:

 

“(iii) take such other action
or actions as the Collateral Agent may be directed in writing from time to time by the holders of at least 50% of the outstanding
principal of the Company Notes (as defined in the Securities Purchase Agreement) (the “Required Holders”) to
create, perfect, preserve or maintain the Secured Parties’ security interest in the Collateral or enforce any and all rights
and remedies, in whole or in part, available to the Secured Parties under the Collateral Documents with respect to the Collateral.
In furtherance of the foregoing, the Collateral Agent hereby agrees to promptly take any other action (x) required or directed
in writing by the Required Holders from time to time in order to maintain the perfection of, and preserve or protect, the Secured
Parties’ security interests in the Collateral, (y) necessary in any bankruptcy or insolvency proceeding with respect to any
Debtor to evidence the appointment of the Collateral Agent hereunder and the perfection, preservation and maintenance of the Collateral
in favor of the Secured Parties or (z) permitted or required to be taken by a secured party of record under the UCC and directed
in writing by the Required Holders from time to time in order to carry out more effectively the purposes of this Agreement.”

 

(d)              
Section 1(b) of the Collateral Agency Agreement is hereby amended and restated, in its entirety, as follows:

 

“The Collateral Agent further
agrees that (i) the Buyers shall, and are hereby authorized to, file all initial financing statements against each Debtor with
respect to the Collateral, which financing statements shall list the Collateral Agent as secured party of record thereon, and (ii)
it will not amend, nor will it consent the amendment of, any financing statements filed against any Debtor with respect to the
Collateral without the prior written consent of the Required Holders (not to be unreasonably withheld, conditioned or delayed).”

 

(e)              
The last sentence of Section 2(b) of the Collateral Agency Agreement is hereby amended and restated, in its entirety, as
follows:

 

“If the Collateral Agent shall
not have received further instruction from the Required Holders within 10 business days following the date on which the Collateral
Agent sent an Expiration Notice with respect to an Expiring Financing Statement, the Collateral Agent shall be, and hereby is,
authorized to file, in the appropriate filing office, a continuation statement with respect to such Expiring Financing Statement
and shall provide evidence of the same to the Buyers.”

 

     -3-

     

    

 

(f)               
Section 4 of the Collateral Agency Agreement is hereby amended and restated, in its entirety, as follows:

 

“Section 4. Term; Termination.
This Agreement shall remain in full force and effect until its termination in accordance with this Section 4. The Buyers (by an
affirmative vote of the Required Holders) may, in their sole discretion, terminate this Agreement and remove the Collateral Agent
from its appointment hereunder at any time by giving the Collateral Agent and the Debtors at least thirty (30) days’ prior
written notice. The Collateral Agent may terminate this Agreement, and resign from its appointment hereunder, by giving the Buyers
at least thirty (30) days’ prior written notice. If the Collateral Agent at any time shall resign, the Buyers shall (by an
affirmative vote of the Required Holders), within ten (10) days after such notice, appoint a successor Collateral Agent which shall
thereupon become the Collateral Agent hereunder and under the Security Document. If no successor Collateral Agent shall have been
so appointed, and shall have accepted such appointment, within the above time frame the retiring Collateral Agent may (but shall
not be obligated to) appoint a successor. Upon the acceptance of any appointment as Collateral Agent hereunder by a successor Collateral
Agent, such successor Collateral Agent shall be entitled to receive from the retiring Collateral Agent such documents of transfer
and assignment as such successor Collateral Agent may reasonably request, and shall thereupon succeed to and become vested with
all rights, powers, privileges and duties of the retiring Collateral Agent. Regardless of whether any such successor has been appointed
and accepted such appointment, the resigning Collateral Agent shall be discharged from its duties and obligations under this Agreement
following the expiration of such thirty (30) day notice period. After the effective date of any retiring Collateral Agent’s
resignation hereunder as collateral agent, the provisions of this Agreement shall inure to its benefit as to any actions taken
or omitted to be taken by it while it was Collateral Agent under this Agreement.”

 

(g)              
Section 7(g) of the Collateral Agency Agreement is hereby amended and restated, in its entirety, as follows:

 

“(g) Unless otherwise provided
in this Agreement, wherever this Agreement or the Collateral Documents requires or provides for the consent, direction, instructions
or waiver of the Collateral Agent or for an act or thing to be done in a manner or to be satisfactory to the Collateral Agent,
the Collateral Agent shall act hereunder and thereunder with the written consent of or under the written instructions or written
direction of the Required Holders. At any time and from time to time, the Collateral Agent may require a written confirmation of
the Required Holders including the outstanding principal of the Company Notes and the holders thereof as of such time.”

 

     -4-

     

    

 

(h)              
Section 10(a) of the Collateral Agency Agreement is hereby amended and restated, in its entirety, as follows:

 

“(a) Extension. The
Buyers and the Company hereby agree to extend all delivery dates set forth in the Securities Purchase Agreement for the granting
of liens securing the Notes and the perfection of the security interests contemplated therein for completion within a period of
thirty (30) days from July 19, 2019, as such period may be extended by the Collateral Agent, in its reasonable discretion; provided,
however, that, the Required Holders may agree in writing to instruct the Collateral Agent not to perfect its security interest,
for the benefit of the Secured Parties, in certain types of Collateral if, in the reasonable judgment of the Required Holders,
the expense or process for achieving such perfection is determined to be unduly burdensome.”

 

(i)                
Schedule 1 of the Collateral Agency Agreement is hereby amended and restated, in its entirety in the form
of Schedule 1 attached hereto.

 

4.            Amendment to the Security Agreement.

 

(a)              
the Preamble of the Security Agreement is hereby amended and restated, in its entirety, as follows:

 

“SECURITY AGREEMENT (as amended, supplemented,
amended and restated or otherwise modified from time to time, this “Agreement”) dated October 19, 2018 made
by APPLIED DNA SCIENCES, INC., a Delaware corporation with headquarters located at 50 Health Sciences Drive, Stony Brook, New York
11790 (the “Grantor”), in favor of DELAWARE TRUST COMPANY, a Delaware corporation, as collateral agent (together
with any successor collateral agent, in such capacity, the “Collateral Agent”) for the benefit of the investors
listed on the Schedule of Buyers (each a “Buyer” and collectively, the “Buyers”; the Buyers
and the Collateral Agent are collectively, with their respective successors and assigns, the “Secured Parties”))
set forth in (i) the Securities Purchase Agreement, dated as of August 31, 2018 (as amended, amended and restated, supplemented
or otherwise modified from time to time, the “August Securities Purchase Agreement”), (ii) the Securities Purchase
Agreement, dated as of November 29, 2018 (as amended, amended and restated, supplemented or otherwise modified from time to time,
the “November Securities Purchase Agreement”, or (iii) the Securities Purchase Agreement, dated July 16, 2019
(as amended, amended and restated, supplemented or otherwise modified from time to time, the “July Securities Purchase
Agreement” and, together with the August Securities Purchase Agreement and the November Securities Purchase Agreement,
collectively, the “Securities Purchase Agreement”), and the other Secured Parties.”

 

     -5-

     

    

 

(b)              
the second WHEREAS clause in each of Exhibits A and B of the Security Agreement is hereby amended and restated, in
its entirety, as follows:

 

“WHEREAS, Grantor is party to the (i)
Securities Purchase Agreement, dated as of August 31, 2018 (the “August Securities Purchase Agreement”), (ii)
the Securities Purchase Agreement, dated as of November 29, 2018 (the “November Securities Purchase Agreement”),
and (iii) the Securities Purchase Agreement, dated as of July 16, 2019 (as amended, amended and restated, supplemented or otherwise
modified from time to time, the “July Securities Purchase Agreement” and, together with the August Securities
Purchase Agreement and the November Securities Purchase Agreement, collectively, the “Securities Purchase Agreement”),
in each case, with the Buyers party thereto.”

 

(c)              
Schedule XI (Excluded Assets) of the Security Agreement is hereby amended and restated, in its entirety, as follows:

 

“Excluded Assets

	 	·	the Equity Interests in Applied DNA Sciences India Private Limited, a corporation formed under the laws of India, owned by the Grantor;
	 	·	the Equity Interests in APDN (B.V.I.) Inc., a corporation formed under the laws of the British Virgin Islands, owned by the Grantor;
	 	·	20% of the Equity Interests in LineaRX, Inc., a Delaware corporation (“LineaRX”), owned by the Grantor; and
	 	·	all Excluded Accounts.”
	
 

	
 

	
 

	 	 	 	 	 

 

5.            Amendment to the Guaranty and Security Agreement.

 

(a)              
the Preamble of the Guaranty and Security Agreement is hereby amended and restated, in its entirety, as follows:

 

“GUARANTY AND SECURITY AGREEMENT (as
amended, supplemented, amended and restated or otherwise modified from time to time, this “Agreement”) dated
October 19, 2018 made by APDN (B.V.I.) INC., a corporation organized under the laws of the British Virgin Islands (the “Grantor”),
in favor of DELAWARE TRUST COMPANY, a Delaware corporation, as collateral agent (together with any successor collateral, in such
capacity, the “Collateral Agent”) for the benefit of the investors listed on the Schedule of Buyers (each a
“Buyer” and collectively, the “Buyers”; the Buyers and the Collateral Agent are collectively,
with their respective successors and assigns, the “Secured Parties”)) set forth in (i) the Securities Purchase
Agreement, dated as of August 31, 2018 (as amended, amended and restated, supplemented or otherwise modified from time to time,
the “August Securities Purchase Agreement”), (ii) the Securities Purchase Agreement, dated as of November 29,
2018 (as amended, amended and restated, supplemented or otherwise modified from time to time, the “November Securities
Purchase Agreement”) and (iii) the Securities Purchase Agreement, dated as of July 16, 2019 (as amended, amended and
restated, supplemented or otherwise modified from time to time, the “July Securities Purchase Agreement” and,
together with the August Securities Purchase Agreement and the November Securities Purchase Agreement, collectively, the “Securities
Purchase Agreement”), and the other Secured Parties.”

 

     -6-

     

    

 

(b)              
the second WHEREAS clause in each of Exhibits A and B of the Guarantor IP Security Agreement is hereby amended and
restated, in its entirety, as follows:

 

“WHEREAS, Grantor is a wholly owned subsidiary
of APPLIED DNA SCIENCES, INC., a Delaware corporation (the “Company”), and the Company is party to the (i) Securities
Purchase Agreement, dated as of August 31, 2018 (the “August Securities Purchase Agreement”), (ii) the Securities
Purchase Agreement, dated as of November 29, 2018 (the “November Securities Purchase Agreement” and (iii) the
Securities Purchase Agreement, dated as of July 16, 2019 (as amended, amended and restated, supplemented or otherwise modified
from time to time, the “July Securities Purchase Agreement” and, together with the August Securities Purchase
Agreement and the November Securities Purchase Agreement, collectively, the “Securities Purchase Agreement”),
in each case, with the Buyers party thereto.”

 

6.            Ratification. This Amendment shall be construed in connection with and as a part of each of the Security Agreement,
the IP Security Agreement, the Guaranty and Security Agreement, the Guarantor IP Security Agreement and Collateral Agency Agreement,
as applicable, and, except as expressly amended by this Amendment, all terms, conditions, covenants, representations and warranties
contained in the Security Agreement, the IP Security Agreement, the Guaranty and Security Agreement, the Guarantor IP Security
Agreement and Collateral Agency Agreement, respectively, are hereby ratified and shall be and remain in full force and effect.
Any and all notices, requests, certificates and other instruments executed and delivered after the execution and delivery of this
Amendment may refer to the Security Agreement, the IP Security Agreement, the Guaranty and Security Agreement, the Guarantor IP
Security Agreement and Collateral Agency Agreement, as applicable, without making specific reference to this Amendment, but nevertheless
all such references shall include this Amendment.

 

7.            Parties Bound. This Amendment shall be binding on and inure to the benefit of (i) each Grantor and (ii) the
Secured Parties, as well as each of their respective heirs, executors, administrators, legal representatives, successors and assigns,
except as otherwise expressly provided for herein.

 

     -7-

     

    

 

8.            Counterparts and Signatures. This Amendment may be executed in any number of counterparts, each of which when
so executed and delivered shall be deemed to be an original, and all of which taken together shall constitute but one and the same
instrument. The transmission or receipt of a facsimile or similar communication being a reproduction of a party’s signature
or initial shall produce the same legal result as the transmission or receipt of an original signature or initial.

 

9.            Severability of Provisions. Any provision of this Amendment which is prohibited and unenforceable in any jurisdiction
shall, as to such jurisdiction, be ineffective to the extent of such prohibitive or enforceability without invalidating the remaining
provisions hereof or affecting the validity or enforceability of such provisions in any other jurisdiction.

 

10.          Section Headings. The Section headings used in this Amendment are for convenience only and shall not affect
the construction of this Amendment.

 

11.          Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State
of New York.

 

12.          Instruction to Collateral Agent. Each of the Buyers, by its acknowledgement hereof, hereby directs the Collateral
Agent to execute and deliver this Amendment, and authorizes the Collateral Agent to take action as agent on its behalf and to exercise
such powers and discretion under the Security Agreement, the Guaranty and Security Agreement and the Collateral Agency Agreement
and the other Transaction Documents (as defined in the Collateral Agency Agreement) as are delegated to the Collateral Agent by
the terms thereof, together with such powers and discretion as are reasonably incidental. This Section 12 is solely for
the benefit of the Collateral Agent and the Buyers and neither the Grantor nor any other Person shall have rights as a third party
beneficiary of the provisions in this Section 12.

 

13.         
Costs and Expenses. Without limiting any expense or indemnity provisions set forth in the Security Agreement,
the Guaranty and Security Agreement and the Collateral Agency Agreement or any other Transaction Document, the Grantor agrees to
pay on demand all reasonable and documented out-of-pocket expenses, fees, and disbursements (including reasonable and documented
attorneys’ fees and expenses) of the Collateral Agent and the Buyers in connection with the negotiation, preparation, execution,
delivery and administration of this Amendment.

 

[remainder of page intentionally left
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     -8-

     

    

 

IN WITNESS WHEREOF, the parties have executed
this Amendment as of the day and year first above written.

 

	 	GRANTORS:
	 	 
	 	APPLIED DNA SCIENCES, INC., a Delaware corporation
	 	 
	 	By:	/s/ Beth Jantzen
	 	Print Name: Beth Jantzen, CPA
	 	Its: Chief Financial Officer
	 	 
	 	APDN (B.V.I.) INC., a corporation formed under the laws of the British Virgin Islands
	 	 
	 	By:	/s/ James A. Hayward
	 	Print Name: James A. Hayward
	 	Its: Authorized Signatory

  

[Signatures Continue on Following Page]

 

Signature Page to Second Omnibus Amendment
Agreement

 

     

     

    

 

	 	COLLATERAL AGENT
	 	 
	 	DELAWARE TRUST COMPANY,
	 	as Collateral Agent
	 	 
	 	By:	/s/ Alan R. Halpern
	 	Name: Alan R. Halpern
	 	Title: Vice President

 

 

[Signatures Continue on Following Page]

 

Signature Page to Second Omnibus Amendment
Agreement

 

     

     

    

 

ACKNOWLEDGED AND CONSENTED TO BY BUYERS:

 

	By:	/s/ James A. Hayward	 
	Print Name: James A. Hayward	 
	 	 
	By:	/s/ Judith Murrah	 
	Print Name: Judith Murrah	 
	 	 
	By:	/s/ Yavoc Shamash	 
	Print Name: Yavoc Shamash	 
	 	 
	By:	/s/ Robert Catell	 
	Print Name: Robert Catell	 
	 	 
	By:	/s/ Elizabeth Schmalz Ferguson	 
	Print Name: Elizabeth Schmalz Ferguson	 
	 	 
	By:	/s/ Gregg Baldwin	 
	Print Name: Gregg Baldwin	 
	 	 
	By:	/s/ William Montgomery	 
	Print Name: William Montgomery	 
	 	 
	By:	/s/ Johnette van Eeden	 
	Print Name: Johnette van Eeden	 
	 	 
	By:	/s/ John G. Cartier	 
	Print Name: John Cartier	 
	 	 
	By:	/s/ Wayne Buchen	 
	Print Name: Wayne Buchen	 

 

Signature Page to Second Omnibus Amendment
Agreement

 

     

     

    

 

ACKNOWLEDGED AND CONSENTED TO BY BUYERS (continued):

 

	Delabarta II	 
	 	 
	By:	/s/ John Bitzer III	 
	Print Name: John F. Bitzer III	 
	Title: President	 
	 	 
	The Rodgers Living Trust Dated April 7, 1995	 
	 	 
	By:	/s/ Jay D. Rodgers	 
	Print Name: Jay D. Rodgers	 
	Title: Trustee	 
	 	 
	Dillon Hill Capital, LLC	 
	 	 
	By:	/s/ Bruce Grossman	 
	Print Name: Bruce Grossman	 
	Title: Chief Executive Officer	 

 

Signature Page to Second Omnibus Amendment
Agreement

 

     

     

    

 

SCHEDULE
I

SCHEDULE OF BUYERS

 

	Buyer	 	Address for Notices
	James A. Hayward	 	1 Emmet Drive, Stony Brook, NY 11790 and 50 Health Sciences Drive, Stony Brook, NY 11790
	 	 	 
	Judith Murrah	 	8 Old Post Lane, Saint James, NY 11780
	 	 	 
	Delabarta II	 	c/o Delaware Corporate Management, 1105 North Market Street, Suite 1300, Wilmington, DE 19801
	 	 	 
	Yavoc Shamash	 	7 Quaker Hill Road, Stony Brook, NY 11790
	 	 	 
	Robert Catell	 	62 Osborne Road, Garden City, NY 11530
	 	 	 
	Elizabeth Schmalz Ferguson	 	101 Jersey Avenue, Spring Lake, NJ 07762
	 	 	 
	The Rodgers Living Trust Dated April 7, 1995	 	1277 Porter Road, Flower Mound, TX 75022
	 	 	 
	Gregg Baldwin	 	3391 Ichabod Way, The Villages, FL 32163
	 	 	 
	William Montgomery	 	34211 Seavey Loop Road, Eugene, OR 97405
	 	 	 
	Johnette van Eeden	 	451 Westpark Way, Suite 5, Euless, TX 76040
	 	 	 
	John Cartier	 	P.O. Box East Hampton, NY 11937
	 	 	 
	Wayne Buchen	 	50 Health Sciences Drive, Stony Brook, NY 11790
	 	 	 
	Dillon Hill Capital, LLC	 	200
Business Park Drive, Ste 306, Armonk, NY 10504

 

Schedule I to Second Omnibus Amendment
AgreementEXHIBIT 10.8

EXECUTION VERSION

 

SECOND AMENDMENT TO INTELLECTUAL PROPERTY
SECURITY AGREEMENT

(APPLIED DNA SCIENCES, INC.)

 

This SECOND AMENDMENT
TO INTELLECTUAL PROPERTY SECURITY AGREEMENT (this “Amendment”), dated as of July 19, 2019, is made by APPLIED
DNA SCIENCES, INC., a Delaware corporation (the “Grantor”) in favor of DELAWARE TRUST COMPANY, a
Delaware corporation, as collateral agent (together with its successors and assigns, in such capacity, the “Collateral
Agent”) for the benefit of the Secured Parties (as defined in the Security Agreement referred to below).

 

W I T N E S S E T H:

 

WHEREAS, the
Grantor and the Collateral Agent are parties to that certain Security Agreement, dated as of October 19, 2018 (as amended, amended
and restated, supplemented or otherwise modified from time to time, the “Security Agreement”), whereby the Grantor
granted a security interest in substantially all of its tangible and intangible assets, whether real or personal property, now
or hereafter acquired (the “Collateral”), to the Collateral Agent for the ratable benefit of the Secured Parties;

 

WHEREAS, in
connection with the Security Agreement, the Issuer executed and delivered that certain Intellectual Property Security Agreement,
dated as of October 19, 2018 and amended by that certain First Amendment to Intellectual Property Security Agreement, dated February
26, 2019 (as so amended and as may be further amended, amended and restated, supplemented or otherwise modified from time to time,
the “IP Security Agreement”) in favor of the Collateral Agent for the ratable benefit of the Secured Parties;

 

WHEREAS, the
Grantor has requested and the Secured Parties, by their execution and acknowledgement hereof, have each agreed, subject to the
terms of this Amendment, to amend the Security Agreement as provided herein; and

 

NOW, THEREFORE,
the parties hereto hereby agree as follows, for good and valuable consideration, the receipt and sufficiency of which is hereby
acknowledged:

 

1.            
Definitions. Capitalized terms used and not otherwise defined in this Amendment shall have the respective
meanings given to such terms in the IP Security Agreement.

 

2.            
Amendment to the IP Security Agreement. The parties hereto agree, intending to be legally bound, the second
“WHEREAS” clause of the IP Security Agreement is hereby amended and restated, in its entirety, as follows:

 

“WHEREAS,
Grantor is party to the (i) Securities Purchase Agreement, dated as of August 31, 2018 (the “August Securities Purchase
Agreement”), (ii) the Securities Purchase Agreement, dated as of November 29, 2018 (the “November Securities
Purchase Agreement”), and (iii) the Securities Purchase Agreement, dated as of July 16, 2019 (as amended, amended and
restated, supplemented or otherwise modified from time to time, the “July Securities Purchase Agreement” and,
together with the August Securities Purchase Agreement and the November Securities Purchase Agreement, collectively, the “Securities
Purchase Agreement”), in each case, with the Buyers party thereto.”

 

 

     

     

    

 

3.            
Ratification. Except as specifically modified herein, the terms of the IP Security Agreement shall remain
in full force and effect. This Amendment shall be construed in connection with and as a part of the IP Security Agreement and,
except as expressly amended by this Amendment, all terms, conditions, covenants, representations and warranties contained in the
IP Security Agreement is hereby ratified and shall be and remain in full force and effect. Any and all notices, requests, certificates
and other instruments executed and delivered after the execution and delivery of this Amendment may refer to the IP Security Agreement
without making specific reference to this Amendment, but nevertheless all such references shall include this Amendment.

 

4.            
Parties Bound. This Amendment shall be binding on and inure to the benefit of (i) the Grantor and (ii) the
Secured Parties, as well as each of their respective heirs, executors, administrators, legal representatives, successors and assigns,
except as otherwise expressly provided for herein.

 

5.            Counterparts and Signatures. This Amendment may be executed in any number of counterparts, each of which when
so executed and delivered shall be deemed to be an original, and all of which taken together shall constitute but one and the same
instrument. The transmission or receipt of a facsimile or similar communication being a reproduction of a party’s signature
or initial shall produce the same legal result as the transmission or receipt of an original signature or initial.

 

6.            Severability of Provisions. Any provision of this Amendment which is prohibited and unenforceable in any jurisdiction
shall, as to such jurisdiction, be ineffective to the extent of such prohibitive or enforceability without invalidating the remaining
provisions hereof or affecting the validity or enforceability of such provisions in any other jurisdiction.

 

7.            Section Headings. The Section headings used in this Amendment are for convenience only and shall not affect
the construction of this Amendment.

 

8.            Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State
of New York.

 

9.            Costs and Expenses. Without limiting any expense or indemnity provisions set forth in the IP Security Agreement,
the Grantor agrees to pay on demand all reasonable and documented out-of-pocket expenses, fees, and disbursements (including reasonable
and documented attorneys’ fees and expenses) of the Collateral Agent in connection with the negotiation, preparation, execution,
delivery and administration of this Amendment.

 

[remainder of page intentionally left
blank]

 

     

     

    

 

IN WITNESS WHEREOF, the parties have executed
this Amendment as of the day and year first above written.

 

	 	 	GRANTOR:
	 	 	 	 
	 	 	APPLIED DNA SCIENCES, INC., a Delaware corporation
	 	 	 	 
	 	 	By:	/s/ Beth Jantzen
	 	 	Print Name:  Beth Jantzen, CPA
	 	 	Its:  Chief Financial Officer

 

Signature Page to Second Amendment to
IP Security Agreement (Issuer)

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