Document:

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                                                                     Exhibit 4.1

                               LABRANCHE & CO INC.
                              EQUITY INCENTIVE PLAN

                  1. PURPOSE. The purpose of the LaBranche & Co Inc. Equity
Incentive Plan (the "Plan") is to establish a flexible vehicle through which
LaBranche & Co Inc., a Delaware corporation (the "Company"), can offer
equity-based compensation incentives to eligible personnel of the Company and
its subsidiaries and affiliates (collectively, the "Firm") in order to attract,
retain and motivate such personnel and to further align the interests of such
personnel with those of the stockholders of the Company.

                  2. TYPES OF AWARDS. Awards under the Plan may be in the form
of (a) options to purchase shares of the Company's common stock, $0.01 par value
("Common Stock"), including options intended to qualify as "incentive stock
options" ("ISOs") within the meaning of Section 422 of the Internal Revenue Code
of 1986, as amended (the "Code") and options which do not qualify as ISOs
("NQSOs"), (b) restricted shares of Common Stock, (c) restricted stock units
tied to shares of Common Stock, and (d) other equity-based awards related to
shares of Common Stock, including stock appreciation rights and dividend
equivalents, which the Committee determines to be consistent with the purposes
of the Plan.

                  3. ADMINISTRATION.

                     (a) COMMITTEE. The Plan shall be administered by the Board
of Directors of the Company (the "Board") or a committee or subcommittee thereof
(the "Committee") appointed by the Board. If a Committee is appointed, then,
unless the Board determines otherwise, its members shall consist solely of
individuals who qualify as "non-employee directors" under Rule 16b-3 promulgated
under Section 16 of the Securities Exchange Act of 1934, as amended (the
"Exchange Act") and as "outside directors" under Section 162(m) of the Code. If
for any reason the Committee does not satisfy the "non-employee director"
requirements of Rule 16b-3 or the "outside director" requirements of Section
162(m) of the Code, such non-compliance shall not affect the validity of the
awards, interpretations or other actions of the Committee. Notwithstanding
anything herein to the contrary, the Plan shall be administered solely by the
Board with respect to grants made to non-employee directors of the Company. To
the extent that the Plan is administered by the Board, the Board shall have all
the authority and responsibility granted to the Committee herein.

                     (b) AUTHORITY OF COMMITTEE. Subject to the limitations of
the Plan, the Committee, acting in its sole and absolute discretion, shall have
full power and authority to (i) select the persons to whom awards shall be made
under the Plan, (ii) make awards to such persons and prescribe the terms and
conditions of such awards, (iii) construe, interpret and apply the provisions of
the Plan and of any agreement or other document evidencing an award made under
the Plan, (iv) prescribe, amend and rescind rules and regulations relating to
the Plan, including rules governing its own operations, (v) correct any defect,
supply any omission and reconcile any inconsistency in the Plan, (vi) amend any
outstanding award in any

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respect, including, without limitation, to accelerate the time or times at which
the award becomes vested, unrestricted or may be exercised, (vii) carry out any
responsibility or duty specifically reserved to the Committee under the Plan,
and (viii) make any and all determinations and interpretations and take such
other actions as may be necessary or desirable in order to carry out the
provisions, intent and purposes of the Plan. A majority of the members of the
Committee shall constitute a quorum. The Committee may act by the vote of a
majority of its members present at a meeting at which there is a quorum or by
unanimous written consent.

                     (c) INDEMNIFICATION. The Company shall indemnify and hold
harmless each member of the Committee and any employee or director of the Firm
to whom any duty or power relating to the administration or interpretation of
the Plan is delegated from and against any loss, cost, liability (including any
sum paid in settlement of a claim with the approval of the Board), damage and
expense (including legal and other expenses incident thereto) arising out of or
incurred in connection with the Plan, unless and except to the extent
attributable to such person's fraud or wilful misconduct.

                  4. SHARE LIMITATIONS. Subject to adjustment pursuant to
Section 13 below, the maximum number of shares of Common Stock that may be
issued under the Plan is 4,687,500. For this purpose, the following shares shall
be deemed not to have been issued and shall be deemed to remain available for
issuance: (a) shares covered by the unexercised portion of an option or stock
appreciation right that terminates, expires or is canceled, (b) shares of
restricted stock that are forfeited or repurchased in accordance with the terms
of the award, (c) shares represented by restricted stock units or other-equity
based awards that are forfeited, canceled or otherwise terminated, and (d)
shares that are withheld in order to pay the purchase price for shares covered
by any award or to satisfy the tax withholding obligations associated with any
award under the Plan. Shares of Common Stock available for issuance under the
Plan may be authorized and unissued, held by the Company in its treasury or
otherwise acquired for purposes of the Plan. No fractional shares of Common
Stock shall be issued under the Plan. The maximum number of shares of Common
Stock with respect to which awards (including options and stock appreciation
rights) may be granted under the Plan to any employee in any calendar year shall
be 500,000 shares.

                  5. ELIGIBILITY. Awards under the Plan may be made to such
officers, directors, employees (including prospective employees), consultants
and other individuals who may perform services for the Firm, as the Committee
may select. In making awards under the Plan, the Committee shall give
consideration to the functions and responsibilities of a potential recipient,
the potential recipient's previous and/or expected future contributions to the
business of the Firm and such other factors as the Committee deems relevant
under the circumstances.

                  6. STOCK OPTIONS. Subject to the provisions of the Plan, the
Committee may grant options to eligible personnel upon such terms and conditions
as the Committee deems appropriate. The terms and conditions of any option shall
be evidenced by a written option agreement or other instrument approved for this
purpose by the Committee.

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                     (a) EXERCISE PRICE. The exercise price per share of Common
Stock covered by an option granted under the Plan may not be less than the fair
market value per share on the date of grant (or, in the case of an ISO granted
to an optionee who, at the time the option is granted, owns stock possessing
more than 10% of the total combined voting power of all classes of stock of the
Company or a "subsidiary" of the Company within the meaning of Section 424 of
the Code, 110% of fair market value).

                     (b) OPTION TERM. No option granted under the Plan may be
exercisable (if at all) more than ten years after the date the option is granted
(or, in the case of an ISO granted to a ten percent stockholder described in
Section 422 of the Code, five years).

                     (c) VESTING AND EXERCISE OF OPTIONS. The Committee may
establish such vesting and other conditions and restrictions on the exercise of
an option and/or upon the issuance of Common Stock in connection with the
exercise of an option as it deems appropriate. Subject to satisfaction of
applicable withholding requirements, once vested and exercisable, an option may
be exercised by transmitting to the Company (i) a notice specifying the number
of shares to be purchased and (ii) payment of the exercise price. The exercise
price of an option may be paid in cash and/or such other form of payment as the
Company may permit.

                     (d) RIGHTS AS A STOCKHOLDER. No shares of Common Stock
shall be issued in respect of the exercise of an option until full payment of
the exercise price and the applicable tax withholding obligation with respect to
such exercise has been made or provided for. The holder of an option shall have
no rights as a stockholder with respect to any shares covered by an option until
the date such shares are issued. Except as otherwise provided herein, no
adjustments shall be made for dividend distributions or other rights for which
the record date is prior to the date such shares are issued.

                     (e) BUY OUT AND SETTLEMENT. The Committee, on behalf of the
Company, may at any time offer to buy out any outstanding option on such terms
and conditions as the Committee shall establish.

                  7. RESTRICTED STOCK AND RESTRICTED STOCK UNITS. Subject to the
provisions of the Plan, the Committee may award restricted shares of Common
Stock and/or restricted stock units tied to shares of Common Stock to eligible
personnel upon such terms and subject to such conditions and restrictions as the
Committee deems appropriate. The terms and conditions of any restricted stock or
restricted stock unit award shall be evidenced by a written agreement or other
instrument approved for this purpose by the Committee.

                     (a) PURCHASE PRICE. The purchase price payable for shares
of restricted stock and for shares issued pursuant to the settlement of a
restricted stock unit may be as low as zero, provided, however, that to the
extent required by applicable law, the purchase price per share shall be no less
than the par value of a share of Common Stock.

                     (b) RESTRICTIONS AND VESTING. The Committee may establish
such conditions and restrictions on the vesting of restricted stock and
restricted stock units and

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on the issuance of shares of restricted stock as it deems appropriate,
including, without limitation, conditions and restrictions based upon continued
service, the attainment of specified performance goals and/or other factors and
criteria deemed relevant for this purpose.

                     (c) RIGHTS AS A STOCKHOLDER. The holder of restricted stock
units awarded under the Plan shall have only the rights of a general unsecured
creditor of the Company and shall have no rights as a stockholder with respect
to the shares of Common Stock referenced by such units until such shares are
issued in the name of the holder following the satisfaction or expiration of the
vesting and other conditions and restrictions applicable to such units. The
recipient of restricted stock shall have the rights of a stockholder with
respect to the restricted stock, subject to any restrictions and conditions as
the Committee may impose.

                     (d) STOCK CERTIFICATES FOR RESTRICTED STOCK. Unless the
Committee elects otherwise, shares of restricted stock shall be evidenced by
book entries on the Company's stock transfer records pending the expiration of
restrictions thereon. If a stock certificate for shares of restricted stock is
issued, it shall bear an appropriate legend to reflect the nature of the
restrictions applicable to the shares represented by the certificate, and the
Committee may require that any or all such stock certificates be held in custody
by the Company until the applicable restrictions have lapsed. The Committee may
establish such other conditions as it deems appropriate in connection with the
issuance of certificates for shares of restricted stock, including, without
limitation, a requirement that the grantee deliver a duly signed stock power,
endorsed in blank, for the shares covered by the award.

                     (e) LAPSE OF RESTRICTIONS. If and when the vesting
conditions and other restrictions applicable to a restricted stock or restricted
stock unit award are satisfied or expire, a certificate for the shares covered
or referenced by the award, to the extent vested and free of restrictions, shall
be delivered to the holder. All legends shall be removed from said certificates
at the time of delivery except as otherwise required by applicable law.

                  8. OTHER EQUITY-BASED AWARDS. The Committee may grant other
types of equity-based awards, including, without limitation, the grant or offer
for sale of unrestricted shares of Common Stock and/or the grant of stock
appreciation rights or dividend equivalents, in such amounts and subject to such
terms and conditions as the Committee shall determine. Such awards may entail
the transfer of actual shares of Common Stock to Plan participants, or payment
in cash or otherwise of amounts based on the value of shares of Common Stock and
may include, without limitation, awards designed to comply with or take
advantage of the applicable local laws or jurisdictions other than the United
States.

                  9. TERMINATION OF EMPLOYMENT OR SERVICE. Unless otherwise
determined by the Committee at grant or, if no rights of the recipient are
thereby reduced, thereafter, and subject to earlier termination in accordance
with the provisions hereof, the following rules apply with regard to awards held
by a recipient at the time of his or her termination of employment or other
service with the Firm:

                     (a) STOCK OPTIONS AND STOCK APPRECIATION RIGHTS.

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                         (i) TERMINATION BY REASON OF DEATH. If a participant's
employment or service terminates by reason of his or her death, then any option
or stock appreciation right held by the deceased participant shall thereupon
become fully vested and may be exercised by the deceased participant's
beneficiary at any time within one year from the date of death but in no event
after expiration of the stated term and, to the extent not exercised within such
time period, will be canceled.

                         (ii) TERMINATION BY REASON OF DISABILITY. If a
participant's employment or service is terminated by the Firm due to his or her
Disability (as hereinafter defined), then any option or stock appreciation right
held by the participant, to the extent exercisable on the date his or her
employment or service terminates, may be exercised by the participant at any
time within one year from the date his or her employment or service terminates
but in no event after expiration of the stated term, and, to the extent not
exercised within such time period, will be canceled. If the participant dies
during such one-year period, then the deceased participant's beneficiary may
exercise the option or stock appreciation right, to the extent exercisable by
the deceased participant immediately prior to his or her death, for a period of
one year following the date of death but in no event after expiration of the
stated term. "Disability" means a participant's absence from employment for at
least 180 days in any twelve month period as a result of his or her incapacity
due to physical or mental illness, as determined by the Committee.

                         (iii) TERMINATION FOR CAUSE. If a participant's
employment or service is terminated by the Firm for Cause (as hereinafter
defined) or if, at the time of a participant's termination, a ground for
termination for Cause exists, then, notwithstanding anything to the contrary
contained herein, any option or stock appreciation right held by the participant
(whether or not otherwise vested) shall immediately terminate and cease to be
exercisable. "Cause" means (A) in the case where there is no employment or
consulting agreement between the participant and the Firm or where such an
agreement exists but does not define "Cause" (or words of like import), a
termination classified by the Firm as a termination due to the participant's
dishonesty, fraud, insubordination, willful misconduct, refusal to perform
services or materially unsatisfactory performance of his or her duties, or (B)
in the case where there is an employment or consulting agreement between the
participant and the Firm, a termination that is or would be deemed for "cause"
(or words of like import) under such agreement.

                         (iv) OTHER TERMINATION. If a participant's employment
or service terminates for any reason (other than death, Disability or Cause or
at a time when Cause exists) or no reason, then any option or stock appreciation
right held by the participant, to the extent not then exercisable, shall
thereupon terminate. Any option or stock appreciation right held by the
participant which is exercisable at the time of such termination of employment
or service shall remain exercisable during the thirty-day period following such
termination of employment or service or, if sooner, until the expiration of the
stated term of the option or stock appreciation right and, to the extent not
exercised within such period, shall thereupon terminate.

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                      (b) RESTRICTED STOCK, RESTRICTED STOCK UNITS AND
OTHER-EQUITY BASED AWARDS. Unless otherwise determined by the Committee, upon
the termination of a recipient's employment or service for any reason
(including, without limitation, death or Disability) or no reason, any shares of
restricted stock, restricted stock units or other equity- based awards (other
than stock options and stock appreciation rights covered by Section 9(a) hereof)
which have not yet become fully vested shall be forfeited, and any certificate
therefor or book entry with respect thereto or other evidence thereof shall be
canceled.

                  10. FAIR MARKET VALUE. For purposes of the Plan, the fair
market value of a share of Common Stock, as of any date, shall be determined in
good faith by the Board in a uniform and consistent manner.

                  11. NON-TRANSFERABILITY. No stock option or stock appreciation
right granted under the Plan shall be transferable by the recipient other than
upon the recipient's death to a beneficiary designated by the recipient in a
manner acceptable to the Committee, or, if no designated beneficiary shall
survive the recipient, pursuant to the recipient's will or by the laws of
descent and distribution. All stock options and stock appreciation rights shall
be exercisable during the recipient's lifetime only by the recipient. Shares of
restricted stock and restricted stock units may not be transferred prior to the
date on which shares are issued or, if later, the date on which such shares have
vested and are free of any applicable restriction imposed hereunder. Except as
otherwise specifically provided by law or the provisions hereof or the
applicable award agreement or instrument, no award received under the Plan may
be transferred in any manner, and any attempt to transfer any such award shall
be void, and no such award shall in any manner be liable for or subject to the
debts, contracts, liabilities, engagements or torts of any person who shall be
entitled to such award, nor shall it be subject to attachment or legal process
for or against such person. Notwithstanding the foregoing, the Committee may
determine at the time of grant or thereafter that an NQSO is transferable in
whole or part to such persons, under such circumstances, and subject to such
conditions as the Committee may prescribe.

                  12. OTHER CONDITIONS. The Committee may impose such other
conditions with respect to the grant of awards or the issuance of shares of
Common Stock pursuant to the Plan, including, without limitation, conditions
relating to the application of federal or state securities laws or exchange
requirements as it deems necessary or advisable.

                  13. CAPITAL CHANGES; CHANGE IN CONTROL; MERGER.

                      (a) ADJUSTMENTS UPON CHANGES IN CAPITALIZATION. The
aggregate number and class of shares for which awards may be granted under the
Plan, the maximum number of shares that may be covered by individual awards in
any year, the number and class of shares covered by each outstanding award and,
if applicable, the exercise price per share shall all be adjusted
proportionately or as otherwise appropriate to reflect any increase or decrease
in the number of issued shares of Common Stock resulting from a split-up or
consolidation of shares or any like capital adjustment, or the payment of any
stock dividend, and/or to reflect a change in the character or class of shares
covered by the Plan arising from a readjustment or recapitalization of the
Company's capital stock.

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                      (b) CHANGE IN CONTROL. The Committee may provide in any
award agreement for the effect on the award of a "change in control" of the
Company or any of its subsidiaries or affiliates (as such term is defined by the
Committee in any such award agreement), including, without limitation, the
acceleration of the exercisability of, or the lapse of restrictions or deemed
satisfaction of goals with respect to, any outstanding awards.

                      (c) MERGER; CONSOLIDATION. Unless otherwise provided in
the applicable award agreement, in the event of a merger, consolidation,
mandatory share exchange or other similar business combination of the Company
with or into any other entity ("Successor Entity") or any transaction in which
another person or entity acquires all the issued and outstanding Common Stock,
or all or substantially all the assets of the Company, outstanding awards may be
assumed or an equivalent award may be substituted by the Successor Entity or a
parent or subsidiary of the Successor Entity.

                      (d) FRACTIONAL SHARES. In the event of any adjustment in
the number of shares covered by any option pursuant to the provisions hereof,
any fractional shares resulting from such adjustment shall be disregarded, and
each such option shall cover only the number of full shares resulting from the
adjustment.

                      (e) DETERMINATIONS FINAL. All adjustments under this
Section 13 shall be made by the Committee, and its determination as to what
adjustments shall be made, and the extent thereof, shall be final, binding and
conclusive.

                  14. TAX WITHHOLDING. As a condition to the exercise of any
award or the delivery of any shares of Common Stock pursuant to any award or the
lapse of restrictions on any award, or in connection with any other event that
gives rise to a federal or other governmental tax withholding obligation on the
part of the Firm relating to an award, (a) the Firm may deduct or withhold (or
cause to be deducted or withheld) from any payment or distribution to a grantee
whether or not pursuant to the Plan or (b) the Firm shall be entitled to require
that the grantee remit cash to the Firm (through payroll deduction or
otherwise), in each case in an amount sufficient in the opinion of the Company
to satisfy such withholding obligation. If the event giving rise to the
withholding obligation involves a transfer of shares of Common Stock, then,
unless the applicable award agreement provides otherwise, at the discretion of
the Committee, the grantee may satisfy the withholding obligation described
under this Section 14 by electing to have the Company withhold shares of Common
Stock (which withholding will be at a rate not in excess of the statutory
minimum rate) or by tendering previously owned shares of Common Stock, in each
case having a fair market value equal to the amount of tax to be withheld (or by
any other mechanism as may be required or appropriate to conform with local tax
and other rules).

                  15. AMENDMENT AND TERMINATION. The Board may amend or
terminate the Plan, provided, however, that no such action may affect adversely
the accrued rights of the holder of any outstanding award without the consent of
the holder. Except as otherwise provided in Section 13, any amendment which
would increase the number of shares of Common Stock for which awards may be
granted under the Plan (in the aggregate or on an individual basis) or

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modify the class of individuals eligible to receive awards under the Plan shall
be subject to the approval of the Company's stockholders. The Committee may
amend the terms of any agreement or certificate made or issued hereunder at any
time and from time to time, provided, however, that any amendment which would
adversely affect the accrued rights of the holder may not be made without his or
her consent.

                  16. NO RIGHTS CONFERRED. Nothing contained herein shall be
deemed to give any individual any right to receive an award under the Plan or to
be retained in the employ or service of the Firm.

                  17. DECISIONS AND DETERMINATIONS TO BE FINAL. All decisions
and determinations made by the Board pursuant to the provisions hereof and,
except to the extent rights or powers under the Plan are reserved specifically
to the discretion of the Board, all decisions and determinations of the
Committee shall be final, binding and conclusive.

                  18. GOVERNING LAW. All rights and obligations under the Plan
and each award agreement or instrument shall be governed by and construed in
accordance with the laws of the State of New York, without regard to its
principles of conflict of laws.

                  19. TERM OF THE PLAN. The Plan shall become effective on the
date of its adoption by the Board. Unless sooner terminated by the Board, the
Plan shall terminate on the tenth anniversary of the date of its adoption by the
Board. The rights of any person with respect to an award made under the Plan
that is outstanding at the time of the termination of the Plan shall not be
affected solely by reason of the termination of the Plan and shall continue in
accordance with the terms of the award (as then in effect or thereafter amended)
and the Plan.

                                       8<PAGE>

                                                                     EXHIBIT 4.2

                                                         AEROGEN, INC.

                                                  FOURTH AMENDED AND RESTATED
                                                       INFORMATION AND
                                                 REGISTRATION RIGHTS AGREEMENT

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                                                       TABLE OF CONTENTS

<TABLE>
<CAPTION>

                                                                                                               PAGE
<S>                                                                                                            <C>
1.       CERTAIN DEFINITIONS......................................................................................1

2.       DEMAND REGISTRATION......................................................................................2

         2.1      Request for Registration on Form Other Than Form S-3............................................2

         2.2      Right of Deferral of Registration on Form Other Than Form S-3...................................3

         2.3      Request for Registration on Form S-3............................................................3

         2.4      Registration of Other Securities in Demand Registration.........................................3

         2.5      Underwriting in Demand Registration.............................................................3

                  2.5.1    Notice of Underwriting.................................................................3

                  2.5.2    Inclusion of Other Holders in Demand Registration......................................4

                  2.5.3    Selection of Underwriter in Demand Registration........................................4

                  2.5.4    Marketing Limitation in Demand Registration............................................4

                  2.5.5    Right of Withdrawal in Demand Registration.............................................4

         2.6      Blue Sky in Demand Registration.................................................................5

3.       PIGGYBACK REGISTRATION...................................................................................5

         3.1      Notice of Piggyback Registration and Inclusion of Registrable Securities........................5

         3.2      Underwriting in Piggyback Registration..........................................................5

                  3.2.1    Notice of Underwriting in Piggyback Registration.......................................5

                  3.2.2    Marketing Limitation in Piggyback Registration.........................................5

                  3.2.3    Allocation of Shares in Piggyback Registration.........................................6

                  3.2.4    Withdrawal in Piggyback Registration...................................................6

         3.3      Blue Sky in Piggyback Registration..............................................................6

4.       EXPENSES OF REGISTRATION.................................................................................6

5.       REGISTRATION PROCEDURES..................................................................................6

6.       INFORMATION FURNISHED BY HOLDER..........................................................................7

7.       INDEMNIFICATION..........................................................................................8

         7.1      Company's Indemnification of Holders............................................................8

         7.2      Holder's Indemnification of Company.............................................................8

         7.3      Indemnification Procedure.......................................................................9

         7.4      Contribution....................................................................................9

         7.5      Underwriting Agreement.........................................................................10

                                                           i.

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                                                       TABLE OF CONTENTS
                                                          (CONTINUED)

                                                                                                               PAGE
                                                                                                               <C>

         7.6      Survival.......................................................................................10

8.       LIMITATIONS ON REGISTRATION RIGHTS GRANTED TO OTHER SECURITIES..........................................10

9.       TRANSFER OF RIGHTS......................................................................................10

10.      MARKET STAND-OFF........................................................................................11

11.      TERMINATION OF REGISTRATION RIGHTS......................................................................11

12.      FINANCIAL STATEMENTS AND REPORTS TO HOLDERS.............................................................11

         12.1     General........................................................................................11

         12.2     Major Holders..................................................................................12

13.      INSPECTION..............................................................................................12

14.      USE OF INFORMATION; TERMINATION OF COVENANTS............................................................13

15.      SMALL BUSINESS STOCK....................................................................................13

16.      RIGHT OF FIRST OFFER....................................................................................13

         16.1     General........................................................................................13

         16.2     Notice.........................................................................................13

         16.3     Election.......................................................................................13

         16.4     Company Rights.................................................................................14

         16.5     Definitions....................................................................................14

         16.6     Exceptions.....................................................................................15

         16.7     Transfer of Rights.............................................................................15

17.      MISCELLANEOUS...........................................................................................15

         17.1     Entire Agreement; Successors and Assigns.......................................................15

         17.2     Governing Law..................................................................................15

         17.3     Counterparts...................................................................................15

         17.4     Headings.......................................................................................15

         17.5     Notices........................................................................................16

         17.6     Amendment of Agreement.........................................................................16

         17.7     Amendment and Restatement of Prior Rights Agreement............................................16

         17.8     Changes in Registrable Securities..............................................................16
</TABLE>

                                                          ii.
<PAGE>

                           FOURTH AMENDED AND RESTATED

                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT

         This FOURTH AMENDED AND RESTATED INFORMATION AND REGISTRATION RIGHTS
AGREEMENT (the "Agreement") is made as of July 7, 2000, by and among AeroGen,
Inc., a Delaware corporation (the "Company"), and the persons listed on the
attached Schedule A (collectively, the "Holders").

                                    RECITALS

         A.   The Company and certain Holders are parties to that certain
Third Amended and Restated Information and Registration Rights Agreement dated
August 25, 1998, as amended March 10, 2000 (the "Prior Rights Agreement"),
which grants rights to the Common Stock issuable upon conversion of the shares
owned by, and information to, such Holders, which registration, information
and other rights are hereby terminated and superseded by this Agreement.

         B.   On the date hereof, the Company is issuing and selling shares of
its Series F Preferred Stock to certain Holders and is, therefore, amending
and restating the Prior Rights Agreement.

         C.   The Company wishes to enter into this Agreement to grant the
Holders registration rights with respect to the shares of Common Stock
issuable upon conversion of the Preferred Stock and to provide information
rights to each Holder.

         The Parties Agree As Follows:

         1.   CERTAIN DEFINITIONS.  As used in this Agreement, the following
terms shall have the following respective meanings:

                        (a)     "COMMISSION" shall mean the Securities and
Exchange Commission or any other federal agency at the time administering the
Securities Act.

                        (b)     "CONVERTIBLE SECURITIES" shall mean securities
of the Company convertible into or exchangeable for Registrable Securities.

                        (c)     "FORM S-3" shall mean Form S-3 issued by the
Commission or any substantially similar form then in effect.

                        (d)     "HOLDER" shall mean any holder of outstanding
Registrable Securities which have not been sold to the public or Convertible
Securities, but only if such holder is identified on Schedule A or an assignee
or transferee of Registration rights as permitted by Section 9.

                                        1.
<PAGE>

                        (e)     "INITIATING HOLDERS" shall mean Holders who in
the aggregate hold at least aggregate fifty percent (50%) of the Registrable
Securities.

                        (f)     "MATERIAL ADVERSE EVENT" shall mean an
occurrence having a consequence that either (a) is materially adverse as to
the business, properties, prospects or financial condition of the Company or
(b) is reasonably foreseeable, has a reasonable likelihood of occurring, and
if it were to occur might materially adversely affect the business,
properties, prospects or financial condition of the Company.

                        (g)     The terms "REGISTER", "REGISTERED" and
"REGISTRATION" refer to a registration effected by preparing and filing a
registration statement in compliance with the Securities Act ("Registration
Statement"), and the declaration or ordering of the effectiveness of such
Registration Statement.

                        (h)     "REGISTRABLE SECURITIES" shall mean all Common
Stock not previously sold to the public issued or issuable upon conversion or
exercise of any of the Company's Convertible Securities identified on Schedule
A purchased by or issued to the Holders, including Common Stock issued
pursuant to stock splits, stock dividends and similar distributions, and any
securities of the Company granted Registration rights pursuant to Section 8 of
this Agreement; PROVIDED, HOWEVER, that for the purposes of Section 2 and
Section 16 hereof, the Series E Preferred Stock held by PathoGenesis
Corporation and Becton, Dickinson and Company shall not be deemed Registrable
Securities and PathoGenesis Corporation and Becton, Dickinson and Company will
not be deemed a Holder under Section 2 or Section 16.

                        (i)     "REGISTRATION EXPENSES" shall mean all
expenses incurred by the Company in complying with Sections 2 or 3 of this
Agreement, including, without limitation, all federal and state registration,
qualification and filing fees, NASD fees, fees to list the Registrable
Securities on securities exchanges and quotation systems, printing fees and
disbursements expenses, of counsel for the Company and one special counsel for
Holders (if different from the Company), Blue Sky fees and expenses, and the
expense of any special audits incident to or required by any such Registration.

                        (j)     "SECURITIES ACT" shall mean the Securities Act
of 1933, as amended, or any similar federal statute, and the rules and
regulations of the Commission thereunder, all as the same shall be in effect
at the time.

                        (k)     "SELLING EXPENSES" shall mean all underwriting
discounts and selling commissions applicable to the sale of Registrable
Securities pursuant to this Agreement.

         2.   DEMAND REGISTRATION.

              2.1   REQUEST FOR REGISTRATION ON FORM OTHER THAN FORM S-3.
Subject to the terms of this Agreement, in the event that the Company shall
receive from the Initiating Holders at any time after the earlier of (i) the
date two years after the date of this Agreement or

                                      2.

<PAGE>

(ii) six months following the Company's initial public offering, a written
request that the Company effect any Registration with respect to all or a part
of the Registrable Securities on a form other than Form S-3 for an offering of
at least 20% of the then outstanding Registrable Securities (or any lesser
percent if the reasonably anticipated aggregate net proceeds to the Holders,
the Company and any other selling stockholders would exceed $2,000,000), the
Company shall (i) promptly give written notice of the proposed Registration to
all other Holders and (ii) use its best efforts to effect the Registration, as
expeditiously as practicable, of the Registrable Securities specified in such
request, together with any Registrable Securities of any Holder joining in
such request as are specified in a written request given within 20 days after
written notice from the Company. The Company shall not be obligated to take
any action to effect any such Registration pursuant to this Section 2.1 (i)
within six months of the effective date of a Registration initiated by the
Company or (ii) after the Company has effected three such Registrations
pursuant to this Section 2.1 and such Registrations have been declared
effective.

              2.2   RIGHT OF DEFERRAL OF REGISTRATION ON FORM OTHER THAN FORM
S-3. If the Company shall furnish to all such Holders who joined in the
request a certificate signed by the Chief Executive Officer or President of
the Company stating that, in the good faith judgment of the Board of Directors
of the Company, it would be seriously detrimental to the Company for any
Registration to be effected as requested under Section 2.1 and/or Section 2.3,
the Company shall have the right, exercisable one time only with respect to
such Registration, to defer the filing of a Registration Statement with
respect to such offering for a period of not more than 120 days from delivery
of the request of the Initiating Holders.

              2.3   REQUEST FOR REGISTRATION ON FORM S-3. Subject to the terms
of this Agreement, in the event that the Company receives from Holders who in
the aggregate hold at least twenty-five percent (25%) of the then outstanding
Registrable Securities (or any lesser percent if the reasonably anticipated
net proceeds to the Holders, the Company and any other selling stockholders
would exceed $1,000,000) a written request that the Company effect any
Registration on Form S-3 (or any successor form to Form S-3 regardless of its
designation) at a time when the Company is eligible to register securities on
Form S-3 (or any successor form to Form S-3 regardless of its designation) for
an offering of Registrable Securities, the Company will promptly give written
notice of the proposed Registration to all the Holders and will as soon as
practicable use its best efforts to effect Registration of the Registrable
Securities specified in such request, together with all or such portion of the
Registrable Securities of any Holder joining in such request as are specified
in a written request delivered to the Company within 30 days after written
notice from the Company of the proposed Registration. There shall be no limit
to the number of occasions on which the Company shall be obligated to effect
Registration under this Section 2.3.

              2.4   REGISTRATION OF OTHER SECURITIES IN DEMAND REGISTRATION.
Any Registration Statement filed pursuant to the request of the Initiating
Holders under this Section 2 may, subject to the provisions of Section 2.5,
include securities of the Company other than Registrable Securities.

                                      3.

<PAGE>

              2.5   UNDERWRITING IN DEMAND REGISTRATION.

                    2.5.1    NOTICE OF UNDERWRITING.  If the Holders intend to
distribute the Registrable Securities covered by their request by means of an
underwriting, they shall so advise the Company as a part of their request made
pursuant to this Section 2, and the Company shall include such information in
the written notice referred to in Section 2.1 or 2.3, and the right of any
Holder to Registration pursuant to Section 2 shall be conditioned upon such
Holder's agreement to participate in such underwriting and the inclusion of
such Holder's Registrable Securities in the underwriting.

                    2.5.2    INCLUSION OF OTHER HOLDERS IN DEMAND
REGISTRATION. If the Company, officers or directors of the Company holding
Common Stock other than Registrable Securities or holders of securities other
than Registrable Securities, request inclusion in such Registration, the
Initiating Holders, to the extent they deem advisable and consistent with the
goals of such Registration, shall, on behalf of all Holders, offer to any or
all of the Company, such officers or directors and such holders of securities
other than Registrable Securities that such securities other than Registrable
Securities be included in the underwriting and may condition such offer on the
acceptance by such persons of the terms of this Section 2, provided that no
Holder shall have Registrable Securities excluded from such Registration as a
result of the offer to others without such Holder's written consent. In the
event, however, that the number of shares so included exceeds the number of
shares of Registrable Securities included by all Holders, such Registration
shall be treated as governed by Section 3 hereof rather than Section 2, and it
shall not count as a Registration for purposes of Section 2.1 hereof.

                    2.5.3    SELECTION OF UNDERWRITER IN DEMAND REGISTRATION.
The Company shall (together with all Holders proposing to distribute their
securities through such underwriting) enter into an underwriting agreement, in
customary form, with the representative ("Underwriter's Representative") of
the underwriter or underwriters selected for such underwriting by the Holders
of a majority of the Registrable Securities being Registered by the Holders
and agreed to by the Company in its reasonable business judgment.

                    2.5.4    MARKETING LIMITATION IN DEMAND REGISTRATION. In
the event the Underwriter's Representative advises the Initiating Holders in
writing that market factors (including, without limitation, the aggregate
number of shares of Common Stock and other securities requested to be
Registered, the general condition of the market, and the status of the persons
proposing to sell securities pursuant to the Registration) require a
limitation of the number of shares to be underwritten, then (i) first the
Common Stock (other than Registrable Securities) held by officers or directors
of the Company, (ii) next the securities other than Registrable Securities and
the securities set forth in the following subparagraph (iii), and (iii) last
the securities requested to be Registered by the Company, shall be excluded
from such Registration to the extent required by such limitation. If a
limitation of the number of shares is still required, the Initiating Holders
shall so advise all Holders and the number of shares of Registrable Securities
that may be included in the Registration and underwriting shall be allocated
among all Holders in proportion, as nearly as practicable, to the respective
amounts of

                                      4.

<PAGE>

Registrable Securities entitled to inclusion in such Registration held by such
Holders at the time of filing the Registration Statement. No Registrable
Securities or other securities excluded from the underwriting by reason of
this Section 2.5.4 shall be included in such Registration Statement.

                    2.5.5    RIGHT OF WITHDRAWAL IN DEMAND REGISTRATION. If
any Holder of Registrable Securities, or a holder of other securities entitled
(upon request) to be included in such Registration, disapproves of the terms
of the underwriting, such person may elect to withdraw therefrom by written
notice within a reasonable time prior to the effective date of the
Registration Statement to the Company, the underwriter and the Initiating
Holders. The securities so withdrawn shall also be withdrawn from the
Registration Statement.

              2.6   BLUE SKY IN DEMAND REGISTRATION. In the event of any
Registration pursuant to Section 2, the Company will exercise its best efforts
to Register and qualify the securities covered by the Registration Statement
under such other securities or Blue Sky laws of such jurisdictions as shall be
reasonably appropriate for the distribution of such securities; provided,
however, that the Company shall not be required to qualify to do business or
to file a general consent to service of process in any such states or
jurisdictions, except for those states or jurisdictions in which the Company
is already qualified to do business or subject to consent to service of
process and except as may be required by the Securities Act.

         3.   PIGGYBACK REGISTRATION.

              3.1   NOTICE OF PIGGYBACK REGISTRATION AND INCLUSION OF
REGISTRABLE SECURITIES. Subject to the terms of this Agreement, in the event
the Company decides to Register (either for its own account or the account of
a security holder or holders exercising their respective demand Registration
rights) on a form that would be suitable for a Registration involving solely
Registrable Securities, the Company will: (i) promptly give each Holder
written notice thereof (which shall include a list of the jurisdictions in
which the Company intends to attempt to qualify such securities under the
applicable Blue Sky or other state securities laws) and (ii) include in such
Registration (and any related qualification under Blue Sky laws or other
compliance), and in any underwriting involved therein, all the Registrable
Securities specified in a written request delivered to the Company by any
Holder within 15 days after delivery of such written notice from the Company.

              3.2   UNDERWRITING IN PIGGYBACK REGISTRATION.

                    3.2.1    NOTICE OF UNDERWRITING IN PIGGYBACK REGISTRATION.
If the Registration of which the Company gives notice is for a Registered
public offering involving an underwriting, the Company shall so advise the
Holders as a part of the written notice given pursuant to Section 3.1. In such
event the right of any Holder to Registration shall be conditioned upon such
underwriting and the inclusion of such Holder's Registrable Securities in such
underwriting to the extent provided in this Section 3. All Holders proposing
to distribute their securities through such underwriting shall (together with
the Company and the other holders distributing their securities through such
underwriting) enter into an underwriting agreement in customary form with the
Underwriter's Representative for such offering. The

                                      5.

<PAGE>

Holders shall have no right to participate in the selection of the
underwriters for an offering pursuant to this Section 3.

                    3.2.2    MARKETING LIMITATION IN PIGGYBACK REGISTRATION.
In the event the Underwriter's Representative advises the Holders seeking
Registration of Registrable Securities pursuant to Section 3 in writing that
market factors (including, without limitation, the aggregate number of shares
of Common Stock requested to be Registered, the general condition of the
market, and the status of the persons proposing to sell securities pursuant to
the Registration) require a limitation of the number of shares to be
underwritten, the Underwriter's Representative (subject to the allocation
priority set forth in Section 3.2.3) may exclude some or all Registrable
Securities from such Registration and underwriting.

                    3.2.3    ALLOCATION OF SHARES IN PIGGYBACK REGISTRATION.
In the event that the Underwriter's Representative limits the number of shares
to be included in a Registration pursuant to Section 3.2.2, the number of
shares to be included in such Registration shall be allocated (subject to
Section 3.2.2) in the following manner: The number of shares that may be
included in the Registration and underwriting by selling stockholders shall be
allocated among all other Holders thereof, in proportion, as nearly as
practicable, to the respective amounts of securities which such Holders would
otherwise be entitled to include in such Registration. No Registrable
Securities or other securities excluded from the underwriting by reason of
this Section 3.2.3 shall be included in the Registration Statement.

                    3.2.4    WITHDRAWAL IN PIGGYBACK REGISTRATION.  If any
Holder disapproves of the terms of any such underwriting, he may elect to
withdraw therefrom by written notice to the Company and the underwriter
delivered within a reasonable time prior to the effective date of the
Registration Statement. Any Registrable Securities or other securities
excluded or withdrawn from such underwriting shall be withdrawn from such
Registration.

              3.3   BLUE SKY IN PIGGYBACK REGISTRATION. In the event of any
Registration of Registrable Securities pursuant to Section 3, the Company will
exercise its best efforts to Register and qualify the securities covered by
the Registration Statement under such other securities or Blue Sky laws of
such jurisdictions as shall be reasonably appropriate for the distribution of
such securities; provided, however, that the Company shall not be required to
qualify to do business or to file a general consent to service of process in
any such states or jurisdictions, except for those states or jurisdictions in
which the Company is already qualified to do business or subject to consent to
service of process and except as may be required by the Securities Act.

         4.   EXPENSES OF REGISTRATION. All Registration Expenses incurred in
connection with three Registrations pursuant to Section 2.1, any Registration
pursuant to Section 2.3, and any Registration pursuant to Section 3, shall be
borne by the Company. Notwithstanding the above, if a Registration request
made pursuant to Section 2.1 is subsequently withdrawn at the request of the
Holders of a majority of the Registrable Securities to be Registered, the
Holders shall forfeit their right to one demand Registration pursuant to
Section 2.l unless the Holders pay for any and all expenses of such withdrawn
Registration; provided further, however, that if at the

                                      6.

<PAGE>

time of such withdrawal, the Holders have learned of a Material Adverse Event
with respect to the condition, business or prospects of the Company not known
to the Holders at the time of their request, then the Holders shall not be
required to pay any of such expenses and shall retain their rights pursuant to
Section 2.1 and not forfeit any demand Registrations. All Selling Expenses
shall be borne by the Holders of the securities Registered pro rata on the
basis of the number of shares Registered.

         5.   REGISTRATION PROCEDURES. The Company will keep each Holder whose
Registrable Securities are included in any Registration pursuant to this
Agreement promptly advised as to the initiation and completion of such
Registration. At its expense the Company will:

                             (a)     prepare and file with the Commission a
Registration Statement with respect to such Registrable Securities and use its
best efforts to cause such Registration Statement to become effective, and
keep such Registration Statement effective for a period of up to 120
continuous days or until the Holder or Holders have completed the distribution
described in the Registration Statement relating thereto, whichever first
occurs; provided that such 120-day period shall be extended for a period of
time equal to the period the Holder refrains from selling any Registrable
Securities included in the Registration at the request of the Company or the
underwriter;

                             (b)     prepare and file with the Commission such
amendments and supplements to such Registration Statement and the prospectus
used in connection with such Registration Statement as may be necessary to
comply with the provisions of the Securities Act with respect to the
disposition of all securities covered by such Registration Statement;

                             (c)     furnish to the Holders such numbers of
copies of a prospectus, including a preliminary prospectus, in conformity with
the requirements of the Securities Act, and such other documents as they may
reasonably request in order to facilitate the disposition of Registrable
Securities owned by them;

                             (d)     use its best efforts to obtain clearance
from the National Association of Securities Dealers and cause all such
Registrable Securities included in such Registration to be listed on each
securities exchange (or The Nasdaq Stock Market, as the case may be) on which
similar securities of the Company are then listed;

                             (e)     promptly notify each Holder of
Registrable Securities covered by such Registration Statement, or the Holder's
designated attorney-in-fact, when a prospectus relating thereto covered by
such Registration Statement is required to be delivered under the Securities
Act, of the happening of any event as a result of which the prospectus
included in such Registration Statement, as then in effect, includes an untrue
statement of a material fact or omits to state a material fact required to be
stated therein or necessary to make the statements therein not misleading in
the light of the circumstances then existing; and

                                      7.

<PAGE>

                             (f)     furnish, at the request of any Holder
requesting Registration of Registrable Securities pursuant to this Agreement,
on the date that such Registrable Securities are delivered to the underwriters
for sale in connection with a Registration pursuant to this Agreement, if such
securities are being sold through underwriters, or if such securities are not
being sold through underwriters, on the date that the Registration Statement
with respect to such securities becomes effective (i) an opinion of counsel
representing the Company for purposes of such Registration dated such date, in
such form and substance as is reasonably and customarily given to underwriters
in an underwritten public offering, addressed to the underwriters, if any, and
to the Holders requesting Registration of Registrable Securities and (ii) a
letter dated such date from the independent certified public accountants of
the Company, in such form and substance as is reasonably and customarily given
by independent certified public accountants to underwriters in an underwritten
public offering, addressed to the underwriters, if any, and to the Holders
requesting Registration of Registrable Securities.

         6.   INFORMATION FURNISHED BY HOLDER. It shall be a condition
precedent of the Company's obligations under this Agreement as to any Holder
that such Holder of Registrable Securities included in any Registration
furnish to the Company such information regarding such Holder and the
distribution proposed by such Holder or Holders as shall be required to effect
the registration of such Holder's Registrable Securities; provided, that such
Holder was given a reasonable opportunity to provide the Company with such
information, not to exceed ten (10) days.

         7.   INDEMNIFICATION.

              7.1   COMPANY'S INDEMNIFICATION OF HOLDERS. To the extent
permitted by law, the Company will indemnify each Holder, each of its
officers, directors, trustees, agents and constituent partners, legal counsel
for the Holders, and each person controlling such Holder, with respect to
which Registration, qualification or compliance of Registrable Securities has
been effected pursuant to this Agreement, and each underwriter, if any, and
each person who controls any underwriter against all claims, losses, damages,
liabilities or expenses (or actions in respect thereof) to the extent such
claims, losses, damages, liabilities or expenses arise out of or are based
upon any untrue statement (or alleged untrue statement) of a material fact
contained in any prospectus or other document (including any related
Registration Statement) incident to any such Registration, qualification or
compliance, or are based on any omission (or alleged omission) to state
therein a material fact required to be stated therein or necessary to make the
statements therein not misleading, or any violation by the Company of the
Securities Act, the Securities Exchange Act of 1934, as amended (the "Exchange
Act"), any state securities law or any rule or regulation promulgated under
the Securities Act, the Exchange Act or any state securities law applicable to
the Company and relating to any such Registration, qualification or
compliance; and the Company will promptly reimburse each such Holder, such
officers, directors, trustees, agents, constituent parties and legal counsel,
each such underwriter and each person who controls any such Holder or
underwriter, for any legal and any other expenses reasonably incurred in
connection with investigating or defending any such claim, loss, damage,
liability, expense or action; provided, however, that the indemnity contained
in this Section 7.1 shall not

                                      8.

<PAGE>

apply to amounts paid in settlement of any such claim, loss, damage, liability
or action if settlement is effected without the consent of the Company (which
consent shall not unreasonably be withheld); and provided, further, that the
Company will not be liable in any such case to the extent that any such claim,
loss, damage, liability or expense arises out of or is based upon and in
conformity with written information furnished to the Company such Holder,
underwriter, or controlling person and expressly stated to be for in use in
connection with the offering of securities of the Company.

              7.2   HOLDER'S INDEMNIFICATION OF COMPANY. To the extent
permitted by law, each Holder will, severally and not jointly, if Registrable
Securities held by such Holder are included in the securities as to which such
Registration, qualification or compliance is being effected pursuant to this
Agreement, indemnify the Company, each of its directors and officers that has
signed the Registration Statement, each legal counsel and independent
accountant of the Company, each underwriter, if any, of the Company's
securities covered by such a Registration Statement, each person who controls
the Company or such underwriter within the meaning of the Securities Act, and
each other such Holder, each of its officers, directors, trustees, agents and
constituent partners and each person controlling such other Holder, against
all claims, losses, damages, liabilities or expenses (or actions in respect
thereof) arising out of or based upon any untrue statement (or alleged untrue
statement) of a material fact contained in any such Registration Statement,
prospectus, offering circular or other document, or any omission (or alleged
omission) to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, or any violation by
such Holder of any rule or regulation promulgated under the Securities Act
applicable to such Holder and relating to action or inaction required of such
Holder in connection with any such Registration, qualification or compliance;
and will reimburse the Company, such Holders, such directors, officers,
trustees, agents, partners, persons, law and accounting firms, underwriters or
control persons for any legal and any other expenses reasonably incurred in
connection with investigating or defending any such claim, loss, damage,
liability or action, in each case to the extent, but only to the extent, that
such untrue statement (or alleged untrue statement) or omission (or alleged
omission) is made in such Registration Statement, prospectus, offering
circular or other document in reliance upon and in conformity with written
information furnished to the Company by such Holder and expressly stated to be
specifically for use in connection with the offering of securities of the
Company, provided, however, that the indemnity contained in this Section 7.2
shall not apply to amounts paid in settlement of any such claim, loss, damage,
liability or action if settlement is effected without the consent of such
Holder (which consent shall not unreasonably be withheld); and provided
further that each Holder's liability under this Section 7.2 shall not exceed
such Holder's net proceeds from the offering of securities made in connection
with such Registration.

              7.3   INDEMNIFICATION PROCEDURE. Promptly after receipt by an
indemnified party under this Section 7 of notice of the commencement of any
action, such indemnified party will, if a claim in respect thereof is to be
made against an indemnifying party under this Section 7, notify the
indemnifying party in writing of the commencement thereof and generally
summarize such action. The indemnifying party shall, after acknowledging in
writing that it is obligated to provide indemnification with respect to such
claim and demonstrating its financial

                                      9.

<PAGE>

ability to pay such claim if adversely determined, have the right to
participate in and to assume the defense of such claim; provided, however,
that the indemnifying party shall be entitled to select counsel for the
defense of such claim only with the approval of any parties entitled to
indemnification, which approval shall not be unreasonably withheld; provided
further, however, that if either party reasonably determines that there may be
conflict between the position of the indemnifying and indemnified parties in
conducting the defense of such action, suit or proceeding by reason of
recognized claims for indemnity under this Section 7, then counsel for such
party shall be entitled to conduct the defense to the extent reasonably
determined by such counsel to be necessary to protect the interest of such
party at the expense of the indemnifying party; provided however, that the
indemnifying party shall not, in connection with any such action, claim or
proceeding or separate but substantially similar or related actions, claims or
proceedings arising out of the same general allegations or circumstances, be
liable for the reasonable fees and expenses of more than one separate counsel
(together with appropriate local counsel) at any time for all such indemnified
parties. The failure to notify an indemnifying party promptly of the
commencement of any such action, if prejudicial to the ability of the
indemnifying party to defend such action, shall relieve such indemnifying
party, to the extent and only to the extent so prejudiced, of liability to the
indemnified party under this Section 7, but the omission so to notify the
indemnifying party will not relieve such party of any liability that such
party may have to any indemnified party otherwise other than under this
Section 7.

              7.4   CONTRIBUTION. If the indemnification provided for in this
Section 7 is held by a court of competent jurisdiction to be unavailable to an
indemnified party with respect to any loss, liability, claim, damage, or
expense referred to therein, then the indemnifying party, in lieu of
indemnifying such indemnified party hereunder, shall contribute to the amount
paid or payable by such indemnified party as a result of such loss, liability,
claim, damage, or expense in such proportion as is appropriate to reflect the
relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the statements or omissions
that resulted in such loss, liability, claim, damage, or expense as well as
any other relevant equitable considerations, provided, however, that each
Holder's aggregate liability under this Section 7.4 and Section 7.2 shall not
exceed such Holder's net proceeds from the offering of securities made in
connection with such Registration. The relative fault of the indemnifying
party and of the indemnified party shall be determined by reference to, among
other things, whether the untrue or alleged untrue statement, of a material
fact or the omission to state a material fact relates to information supplied
by the indemnifying party or by the indemnified party and the parties'
relative intent, knowledge, access to information, and opportunity to correct
or prevent such statement or omission.

              7.5   UNDERWRITING AGREEMENT. If a Holder participates in a
Company-initiated underwritten offering pursuant to Section 3 above, then to
the extent that the provisions relating to indemnification of and contribution
to the underwriter by such Holder contained in the applicable underwriting
agreement conflict with the provisions relating to such indemnification and
contribution contained in this Agreement, the provisions in such underwriting
agreement shall control as between the Holder and the underwriter.

                                     10.

<PAGE>

              7.6   SURVIVAL. The obligations of the Company and Holders under
this Section 7 shall survive the completion of any offering of Registrable
Securities in a registration statement under this Agreement, and otherwise.

         8.   LIMITATIONS ON REGISTRATION RIGHTS GRANTED TO OTHER SECURITIES.
From and after the date of this Agreement, the Company shall not enter into
any agreement with any holder or prospective holder of any securities of the
Company providing for the granting to such holder of any Registration rights
(other than the inclusion hereunder as a "Holder" any holder of Series F
Preferred Stock authorized on the date hereof purchased in compliance with the
Company's Series F Preferred Stock Purchase Agreement of even date herewith,
and as "Registrable Securities" the shares of Common Stock issuable upon
conversion of such Series F Preferred Stock), except that, with the consent of
the Holders of 50% of the aggregate of the Convertible Securities and
Registrable Securities then outstanding, additional holders may be added as
parties to this Agreement with regard to any or all securities of the Company
held by them. Any such additional parties shall execute a counterpart of this
Agreement, and upon execution by such additional parties and by the Company,
shall be considered a Holder for all purposes of this Agreement. The
additional parties and the additional Registrable Securities shall be
identified in an amendment to Schedule A hereto.

         9.   TRANSFER OF RIGHTS. The right to cause the Company to Register
securities granted by the Company to the Holders under this Agreement may be
assigned by any Holder to a transferee or assignee of any Convertible
Securities or Registrable Securities not sold to the public acquiring at least
50% of the then outstanding Convertible Securities or Registrable Securities
(equitably adjusted for any stock splits, subdivisions, stock dividends,
changes, combinations or the like) held by such Holder on the date hereof;
provided, however, that (x) the Company must receive written notice prior to
the time of said transfer, stating the name and address of said transferee or
assignee and identifying the securities with respect to which such information
and Registration rights are being assigned, (y) the transferee or assignee of
such rights must not be a person deemed by the Board of Directors of the
Company, in its best judgment, to be a competitor or potential competitor of
the Company, and (z) the transferee or assignee agrees in writing to be
subject to and bound by the terms of this Agreement. Notwithstanding the
limitation set forth in the foregoing sentence respecting the minimum number
of shares which must be transferred, (i) any Holder which is a partnership may
transfer such Holder's Registration rights to such Holder's constituent
partners; (ii) any Holder or Holders, each of which is a corporation, may
transfer such Holder's or Holders' Registration rights to any corporation or
other entity at least 50% in interest of which is owned by such Holder or
Holders or the owners of at least 50% in interest of such Holder or Holders
without restriction as to the number or percentage of shares acquired by any
such constituent partner, corporation or other entity; (iii) any Holder which
is a registered investment company may transfer such Holder's Registration
rights to another registered investment company with a common investment
advisor; and (iv) any Holder which is a trust may transfer such Holder's
Registration rights to a successor trustee or trustees or to a successor trust
or trusts for the benefit of the same beneficiaries as the beneficiaries of
such Holder.

                                     11.

<PAGE>

         10.  MARKET STAND-OFF. Each Holder hereby agrees that such Holder
shall not sell or otherwise transfer any Registrable Securities or other
securities of the Company during a reasonable and customary period (not to
exceed one hundred eighty (180) days in the case of the Company's initial
public offering and ninety (90) days in the case of any other offering), as
agreed to between the Company and the Underwriter's Representative(s)
following the effective date of a Registration Statement of the Company filed
under the Securities Act; provided that such restriction shall only apply to
the first two Registration Statements of the Company to become effective which
include securities to be sold on behalf of the Company to the public in an
underwritten offering, and shall not apply to any shares purchased in the
initial public offering or in the open market thereafter; provided further,
that all of the Company's officers, directors, affiliates and holders of more
than 10,000 shares of Common Stock are subject to similar restrictions for the
same period of time; provided further, that the holders of Series F Preferred
Stock shall be subject to the restrictions of this Section 10 only with
respect to a Registration Statement filed in connection with the Company's
initial public offering.

         11.  TERMINATION OF REGISTRATION RIGHTS.

                             (a)     Except as set forth in subparagraph (b)
below, the right of any Holder to request registration or inclusion in any
registration pursuant to Section 2.1, 2.3 or 3 shall terminate on the closing
of the first Company-initiated firmly underwritten registered public offering
of Common Stock of the Company, or if all shares of Registrable Securities
held or entitled to be held upon conversion by such Holder may immediately be
sold under Rule 144 during any 90-day period.

                             (b)     The provisions of subparagraph (a) above
shall not apply to any Holder who owns more than one percent (1%) of the
Company's outstanding stock until the earlier of (x) such time as such Holder
owns less than one percent (1%) of the outstanding stock of the Company, or
(y) the expiration of five years after the closing of the first firmly
underwritten registered public offering of Common Stock of the Company.

         12.  FINANCIAL STATEMENTS AND REPORTS TO HOLDERS.

              12.1  GENERAL.  The Company shall deliver to each of the Holders:

                             (a)     as soon as practicable, but in any event
within ninety (90) days after the end of each fiscal year of the Company, a
balance sheet of the Company as of the end of such year and statements of
income and cash flows for such year, which year-end financial reports shall be
in reasonable detail and prepared in accordance with generally accepted
accounting principles consistently applied and shall be audited and
accompanied by the opinion of independent public accountants of recognized
national standing selected by the Company;

                             (b)     as soon as practicable after the end of
the first, second and third quarterly accounting periods in each fiscal year
of the Company, and in any event within forty-five (45) days thereafter, to
each Holder, a balance sheet of the Company as of the end of each such
quarterly period, and a statement of income and a statement of cash flows of
the

                                     12.

<PAGE>

Company for such period and for the current fiscal year to date, prepared in
accordance with generally accepted accounting principles, with the exception
that no notes need be attached to such statements and year-end audit
adjustments may not have been made;

                             (c)     contemporaneously with delivery to
holders of Common Stock of the Company, a copy of each report of the Company
delivered to holders of Common Stock; and

                             (d)     as soon as practicable following
submission to and approval by the Board of Directors of the Company, but in no
event later than 30 days prior to the end of each fiscal year, to each Holder,
the operating budget and plan (the "Plan") respecting the next fiscal year, a
summary of each such Plan containing a monthly financial budget together with
any update of the Plan as such update is prepared and a three-year financial
summary; provided, however, that the Company shall not be obligated to deliver
to any Holder any Plan or any other document under this Section 12.1(d) if the
Board of Directors shall reasonably determine that such Holder is a competitor
of the Company.

              12.2  MAJOR HOLDERS. So long as a Holder (with its affiliates)
shall own not less than 200,000 shares of Preferred Stock (a "Major Holder"),
the Company shall deliver to each such Major Holder:

                             (a)     promptly, but in any event within ten
(10) days, copies of all reports, proxy statements, registration statements
and notifications filed with the SEC or provided to security holders or
directors of the Company or to the financial community;

                             (b)     as soon as practicable, but in any event
within sixty (60) days after the end of each fiscal year of the Company, a
stockholders' list, showing the holders' of all outstanding shares (both
before giving effect to dilution and on a fully-diluted basis) and detailing
all options granted, exercised or lapsed and all stock issued or sold; and

                             (c)     promptly, such other financial data or
other information relating to the business, affairs or financial condition of
the Company as is available to the Company which a Major Holder may reasonably
request.

         13.  INSPECTION. The Company shall permit the Major Holders (or their
designated representative), at such Major Holder's expense, to visit and
inspect the Company's properties, to examine its books of account and records
and to discuss the Company's affairs, finances and accounts with its officers,
all at such reasonable times as may be requested by the Major Holders (or
their designated representative); provided, however, that the Company shall
not be obligated pursuant to this Section 13 to provide any information which
it reasonably considers a trade secret or confidential information.

         14.  USE OF INFORMATION; TERMINATION OF COVENANTS. The covenants of
the Company set forth in Sections 12 and 13 shall be terminated, and be of no
further force or effect, upon the earlier of (a) the consummation of an
underwritten public offering of the Company's

                                     13.

<PAGE>

Common Stock registered under the Securities Act or (b) the date the Company
registers any securities under the Exchange Act.

         15.  SMALL BUSINESS STOCK. The Company shall submit such reports as
the Secretary of the Treasury may require pursuant to Section 1202(d)(1)(c) of
the Internal Revenue Code of 1986, as amended (the "Code"), relating to
certain small business stock. The Company shall not make any election which
would cause it not to be an "eligible corporation" as defined in Section
1202(e)(4) of the Code. The Company shall not acquire or dispose of assets
such that real estate not used in the active conduct of a "qualified trade or
business", as defined in Section 1202(e)(3) of the Code, constitutes more than
ten percent of its assets. The Company shall use at least eighty percent (by
value) of its assets in the conduct of one or more qualified trades or
businesses, as provided in Section 1202(e)(1) of the Code.

         16.  RIGHT OF FIRST OFFER.

              16.1  GENERAL. Subject to the terms and conditions specified in
this Section 16, the Company hereby grants to each Holder, except for Venture
Lending & Leasing, Inc., Venture Lending & Leasing II, Inc., PathoGenesis
Corporation and Becton, Dickinson and Company, a right of first offer with
respect to future sales by the Company of its New Securities (as hereinafter
defined). For purposes of this Section 16, the term Holder includes any
partners, holders or affiliates of the Holder (which shall include another
registered investment company with a common investment advisor). The Holder
shall be entitled to apportion the right of first offer hereby granted among
itself and its partners, holders and affiliates in such proportions as it
deems appropriate.

              16.2  NOTICE. In the event the Company proposes to issue New
Securities, it shall give the Holder written notice (the "Notice") of its
intention stating (i) a description of the New Securities it proposes to
issue, (ii) the number of shares of New Securities it proposes to offer, (iii)
the price per share at which, and other terms on which, it proposes to offer
such New Securities and (iv) the number of shares that the Holder has the
right to purchase under this Section 16, based on the Holder's Percentage as
defined in Section 16.5(b)).

              16.3  ELECTION. Within thirty (30) days after the Notice is
given (in accordance with Section 17.5), the Holder may elect to purchase, at
the price specified in the Notice, up to the number of shares of the New
Securities proposed to be issued that the Holder has the right to purchase as
specified in the Notice. An election to purchase shall be made in writing and
must be given to the Company within such 30-day period (in accordance with
Section 17.5). The closing of the sale of New Securities by the Company to the
participating Holder upon exercise of its rights under this Section 16 shall
take place simultaneously with the closing of the sale of New Securities to
third parties.

              16.4  COMPANY RIGHTS. The Company shall have one hundred twenty
(120) days after the giving of the Notice to enter into an agreement to sell
the New Securities which the Holder did not elect to purchase under this
Section 16, at or above the price and upon terms not materially more favorable
to the purchasers of such securities than the terms specified in the

                                     14.

<PAGE>

initial Notice given in connection with such sale. In the event the Company
has not entered into an agreement to sell the New Securities within such
120-day period, the Company shall not thereafter issue or sell any New
Securities without first offering such New Securities to the Holders in the
manner provided in this Section 16.

              16.5  DEFINITIONS.

                             (a)     "New Securities" shall mean any shares
of, or securities convertible into or exercisable for any shares of, any class
of the Company's capital stock; provided that "New Securities" does not
include: (a) any shares of Series A Preferred Stock, Series B Preferred Stock,
Series C Preferred Stock, Series D Preferred Stock, Series E Preferred Stock
or Series F Preferred Stock authorized for issuance on the date hereof or the
Common Stock issuable upon conversion thereof; (b) securities issued pursuant
to the acquisition of another business entity by the Company by merger,
purchase of substantially all of the assets of such entity, or other
reorganization whereby the Company owns not less than a majority of the voting
power of such entity; (c) shares, or options to purchase shares, of the
Company's Common Stock and the shares of Common Stock issuable upon exercise
of such options, issued pursuant to any arrangement approved by the Board of
Directors to employees, officers and directors of, or consultants, advisors or
other persons performing services for, the Company; (d) shares of the
Company's Common Stock or Preferred Stock of any series issued in connection
with any stock split, stock dividend or recapitalization of the Company; (e)
Common Stock issued upon exercise of warrants, options or convertible
securities if the issuance of such warrants, options or convertible securities
was a result of the exercise of the right of first offer granted under this
Section 16 or was subject to the right of first offer granted under this
Section 16; (f) capital stock or warrants or options for the purchase of
shares of capital stock issued by the Company to a lender in connection with
any loan or lease financing transaction; (g) securities sold to the public in
an offering pursuant to a registration statement filed with the Commission
under the Securities Act; and (h) any securities issued in connection with
strategic transactions involving the Company and other entities, including (i)
joint ventures, manufacturing, marketing or distribution arrangements or (ii)
technology transfer or development arrangements; provided that such strategic
transactions and the issuance of shares therein, has been approved by the
Company's Board of Directors.

                             (b)     The applicable "Percentage" for the
Holder shall be the number of shares of New Securities calculated by dividing
(a) the total number of shares of Common Stock owned by the Holder (assuming
conversion of all shares of Preferred Stock) by (b) the total number of shares
of Common Stock outstanding at the time the Notice is given (assuming
conversion of all shares of Preferred Stock).

              16.6  EXCEPTIONS. The right of first offer granted under this
Section 16 shall not apply to and shall expire upon the consummation of the
Company's sale of its Common Stock in a bona fide, firm commitment
underwriting pursuant to a registration statement on Form S-1 under the
Securities Act (other than a registration statement relating either to the
sale of

                                     15.

<PAGE>

securities to employees of the Company pursuant to a stock option, stock
purchase or similar plan or a transaction under Rule 145 of the Securities
Act).

              16.7  TRANSFER OF RIGHTS. The right of first offer granted under
this section may be assigned by a Holder to a transferee or assignee of the
Holder's shares of the Company's stock acquiring at least 50 percent of the
then outstanding Common Stock (assuming conversion of all shares of Preferred
Stock) held by such Holder on the date hereof. In the event that a Holder
shall assign its right of first offer pursuant to this Section 16.7 in
connection with the transfer of less than all of such Holder's shares of the
Company's stock, such Holder shall also retain such Holder's right of first
offer. Notwithstanding the limitation set forth in the first sentence of this
paragraph respecting the minimum number of shares which must be transferred,
(i) any Holder which is a partnership may transfer such Holder's right of
first offer to such Holder's constituent partners; (ii) any Holder or Holders,
each of which is a corporation, may transfer such Holder's or Holders' right
of first offer to any corporation or other entity at least 50% in interest of
which is owned by such Holder or Holders or the owners of at least 50% in
interest of such Holder or Holders without restriction as to the number or
percentage of shares acquired by such constituent partner, any corporation or
other entity; (iii) any Holder which is a registered, investment company may
transfer such Holder's right of first offer to another registered investment
company with a common investment advisor; and (iv) any Holder which is a trust
may transfer such Holder's right of first offer to a successor trustee or
trustees or to a successor trust or trusts for the benefit of the same
beneficiaries as the beneficiaries of such Holder.

         17.  MISCELLANEOUS.

              17.1  ENTIRE AGREEMENT; SUCCESSORS AND ASSIGNS. This Agreement
constitutes the entire contract between the Company and the Holders relative
to the subject matter hereof. Subject to the exceptions specifically set forth
in this Agreement, the terms and conditions of this Agreement shall inure to
the benefit of and be binding upon the respective executors, administrators,
heirs, successors and assigns of the parties.

              17.2  GOVERNING LAW. This Agreement shall be governed by and
construed in accordance with the laws of the State of California applicable to
contracts entered into and wholly to be performed within the State of
California by California residents.

              17.3  COUNTERPARTS. This Agreement may be executed in two or
more counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

              17.4  HEADINGS. The headings of the Sections of this Agreement
are for convenience and shall not by themselves determine the interpretation
of this Agreement.

              17.5  NOTICES. Any notice required or permitted hereunder shall
be given in writing and shall be conclusively deemed effectively given upon
personal delivery, or five days after deposit in the United States mail, by
registered or certified mail, postage prepaid, addressed

                                     16.

<PAGE>

(i) if to the Company, as set forth below the Company's name on the signature
page of this Agreement, and (ii) if to a Holder, at such Holder's address as
set forth on the Company's books, or at such other address as the Company or
such Holder may designate by ten (10) days' advance written notice to the
Holders or the Company, respectively.

              17.6  AMENDMENT OF AGREEMENT. Any provision of this Agreement
may be amended or waived only by a written instrument signed by the Company
and by persons holding at least fifty percent (50%) of the aggregate of the
Convertible Securities and Registrable Securities then outstanding.

              17.7  AMENDMENT AND RESTATEMENT OF PRIOR RIGHTS AGREEMENT.
Pursuant to Section 17.6 of the Prior Rights Agreement, the Prior Rights
Agreement is hereby amended and restated in its entirety by this Agreement.

              17.8  CHANGES IN REGISTRABLE SECURITIES. If, and as often as,
there are any changes in the Registrable Securities by way of stock split,
stock dividend, combination or reclassification, or through merger,
consolidation, reorganization or recapitalization, or by any other means,
appropriate adjustment shall be made in the provisions of this Agreement, as
may be required, so that the rights and privileges granted hereby shall
continue with respect to the Registrable Securities as so changed. Without
limiting the generality of the foregoing, the Company will require any
successor by merger or consolidation to assume and agree to be bound by the
terms of this Agreement, as a condition to any such merger or consolidation.

                                     17.
<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the day and year first above written.

                                  COMPANY

                                  AEROGEN, INC., a Delaware corporation

                                  By: /s/ Carol Gamble
                                     ------------------------------------------
                                                  Carol Gamble
                                  Vice President, General Counsel and Secretary

                                        18.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                  Bonnie Dennis Living Trust
                                  ------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     ---------------------------------------
                                                Signature

                                  Address: 1080 Autumn Lane
                                           ---------------------------------

                                           Los Altos, CA 94024
                                           ---------------------------------

                                           ---------------------------------

                                        19.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                  Valor Capital Mgmt, L.P.
                                  -----------------------------------------
                                           [Print Name of Holder]

                                  By:   /s/
                                     --------------------------------------
                                                    Signature
                                               John M. Kratky III

                                  Address:          200 Park Ave
                                          ---------------------------------

                                                    Ste. 3900
                                          ---------------------------------

                                                    NY NY 10166
                                          ---------------------------------

                                        20.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Matthew Frank
                                  ------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     ---------------------------------------
                                                    Signature

                                  Address:      2995 Woodside Rd Ste 400
                                          ----------------------------------

                                                Woodside, CA
                                          ----------------------------------

                                                94062
                                          ----------------------------------

                                        21.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           David B. Tuckerman
                                  ------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     ---------------------------------------
                                                    Signature
                                                 CMEA Ventures

                                  Address:       235 Montgomery St. # 920
                                          ----------------------------------

                                                 San Francisco, CA 94104
                                          ----------------------------------

                                          ----------------------------------

                                        22.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Harris Venture Partners, LLC
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                  Signature
                                     Michael S. Resnick, VP,  William Harris

                                  Address: Investors, Inc, as Managing Member
                                          ------------------------------------

                                                2 N. LaSalle St, Suite 400
                                          ------------------------------------

                                                    Chicago, IL 60602
                                          ------------------------------------

                                        23.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Interwest Investors VI, LP
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                    Signature
                                                Managing Director

                                  Address:  3000 Sand Hill Rd. #3-255
                                          ------------------------------------

                                            Menlo Park, CA 94025
                                          ------------------------------------

                                        24.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Interwest Partners VI, LP
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                    Signature
                                                Managing Director

                                  Address: 3000 Sand Hill Rd. #3-255
                                          ------------------------------------

                                            Menlo Park, CA 94025
                                          ------------------------------------

                                        25.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Virdian Capital, L.P.
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                 Signature

                                  Address:        220 Montgomery St #946
                                          ------------------------------------

                                                  San Francisco, CA 94104
                                          ------------------------------------

                                          ------------------------------------

                                        26.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Avery Ventures I
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                  Signature

                                  Address:        130 East Dana St.
                                          ------------------------------------

                                                  Mountain View, CA 94041
                                          ------------------------------------

                                          ------------------------------------

                                        27.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           David Saks
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                  Signature

                                  Address:        2 Knowllwood Road
                                          ------------------------------------

                                                  Woodcliff Lake
                                          ------------------------------------

                                                  N.J. 07675
                                          ------------------------------------

                                        28.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           David B. Musket
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                   Signature

                                    Address:
                                            ----------------------------------

                                            ----------------------------------

                                            ----------------------------------

                                        29.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Hunt Ventures, L.P.
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                  Signature

                                  Address: 1445 Ross Avenue
                                          ------------------------------------

                                                20th Floor
                                          ------------------------------------

                                                Dallas, TX   75202
                                          ------------------------------------

                                        30.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Kensigton Partners, L.P. II
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                    Signature

                                    Address:
                                            ----------------------------------

                                            ----------------------------------

                                            ----------------------------------

                                        31.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Bald Eagle Fund
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                    Signature

                                  Address:

                                          ------------------------------------

                                          ------------------------------------

                                          ------------------------------------

                                        32.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Kensington Partners, L.P.
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                    Signature

                                  Address:
                                          ------------------------------------

                                          ------------------------------------

                                          ------------------------------------

                                        33.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           The Kaufmann Fund
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                  --------------------------------------------
                                                    Signature

                                  Address:          The Kaufmann Fund
                                          ------------------------------------

                                                    140 E. 45th Street
                                          ------------------------------------

                                                    New York, NY 10017
                                          ------------------------------------

                                        34.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Invescp Global Health Services Fund
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                    Signature

                                  Address:          7800 E. Union Ave
                                          ------------------------------------

                                                    Ste 1100
                                          ------------------------------------

                                                    Denver, CO 80237
                                          ------------------------------------

                                        35.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Jonathan J. Carpenter
                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                                    Signature

                                  Address: 1 Larch Drive
                                          ------------------------------------

                                            Atherton
                                          ------------------------------------

                                            CA  94027
                                          ------------------------------------

                                        36.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                  ZAFFARONI REVOCABLE TRUST
                                  D/T/D 1-24-86

                                  --------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                     -----------------------------------------
                                            Signature Alejandro Zaffaroni
                                                       Trustee

                                  Address: 4005 Miranda Avenue
                                          ------------------------------------

                                               Suite 180
                                          ------------------------------------

                                               Palo Alto,  CA 94304
                                          ------------------------------------

                                        37.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           CMEA
                                  ----------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature

                                  Address:
                                            ------------------------------------

                                            ------------------------------------

                                            ------------------------------------

                                        38.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Leeway & Co.
                                  ----------------------------------------------
                                           [Print Name of Holder]
                                                    Leeway & Co. by State Street

                                  By: Bank & Trust Co. a Partner by    /s/
                                      ------------------------------------------
                                                    Signature
                                               Kimberly A. Monyhan
                                               Assistant Vice President
                                  Address:  Leeway & Co. c/o State Street Bank &
                                            Trust
                                            ------------------------------------

                                            One Enterprise Drive - W6C
                                            ------------------------------------

                                            North Quincy, MA 02171
                                            ------------------------------------

                                        39.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Wheatley Partners LP
                                           Wheatley Foreign Partners LP
                                  ----------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature
                                           By Barry Rubenstein, CEO
                                  Address:        Wheatley Partners LLC
                                            ------------------------------------
                                                  General Partner
                                                  80 Cutter Mill Road.. Ste 311
                                            ------------------------------------

                                                  Great Neck, NY 11021
                                            ------------------------------------

                                        40.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           ProMed Partners, L.P.
                                  ----------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature
                                                    Barry Kurokawa
                                  Address:          200 Park Ave, Ste 3900
                                            ------------------------------------

                                                    NY, NY 10166
                                            ------------------------------------

                                            ------------------------------------

                                        41.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           PEC Israel Economic Corporation
                                  ----------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature

                                  Address:  511 Fifth Avenue
                                            ------------------------------------

                                            New York, N.Y. 10017
                                            ------------------------------------

                                            U.S.A.
                                            ------------------------------------

                                        42.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                ------------------------------------------------
                                  The Northern Trust Company not
                                  Individually, but solely in its capacity as
                                  Trustee of the Lucent technologies Inc.
                                ------------------------------------------------
                                  Master Pension Trust
                                ------------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature

                                  Address:          Jeff Bullen
                                            ------------------------------------

                                                    Trust Officer
                                            ------------------------------------

                                            ------------------------------------

                                        43.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

<TABLE>

<S>                                                               <C>
* U.S. VENTURE PARTNERS IV, L.P.                                  * see entities listed on left
By Presidio Management Group IV, L.P.                             ------------------------------------
Its General Patner                                                         [Print Name of Holder]

                                                                  By:      /s/
                                                                      --------------------------------
SECOND VENTURES II, L.P.                                                            Signature
By Presidio Management Group IV, L.P.                                      Michael P. Maher, Attorney-in-Fact
Its General Partner                                               Address: US Venure Partners
                                                                           ---------------------------

                                                                           2180 Sand Hill Road  #300
                                                                           ---------------------------
USVP ENTREPRENEUR PARTNERS II, L.P.
A Delaware Limited Partnership                                             Menlo Park, CA 94025
By Presidio Management Group IV, L.P.                                      ---------------------------

</TABLE>

                                        44.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           PathoGenesis Corp.
                                  ----------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature
                                           Exec. VP & CFO
                                  Address:          5215 Old Orchard Rd
                                            ------------------------------------

                                                    Skokie, IL 60077
                                            ------------------------------------

                                            ------------------------------------

                                        45.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                  Advent Israel (Bermuda) Limited Partnership*
                                  Advent Israel Limited Partnership*
                                  Noptek Limited Partnership*
                                  By: Advent International Limited Partnership,
                                      General Partner
                                  By: Advent International Corporation, General
                                      Partner

                                  By:      /s/
                                      ------------------------------------------
                                           Janet L. Hennessy, Vice President

                                  Advent International Investors II Limited
                                      Partnership
                                  Advent Partners Limited Partnership*
                                  By: Advent International Corporation, General
                                      Partner

                                  By:      /s/
                                      ------------------------------------------
                                           Janet L. Hennessy, Vice President

                                  * c/o Advent International Corporation
                                    75 State Street, 29th Floor
                                    Boston, MA 02109

                                        46.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                  Barry Kurokawa IRA Cowen & Co. Custodian
                                  ----------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature

                                  Address:          280 Park Ave, 31ST Flr
                                            ------------------------------------

                                                    NY,  NY 10017
                                            ------------------------------------

                                            ------------------------------------

                                        47.
<PAGE>

                                  AEROGEN, INC.
                           FOURTH AMENDED AND RESTATED
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT
                        HOLDER COUNTERPART SIGNATURE PAGE

                                           Barry Kurokawa
                                  ----------------------------------------------
                                           [Print Name of Holder]

                                  By:      /s/
                                      ------------------------------------------
                                                    Signature

                                  Address:          37 Highridge Rd
                                            ------------------------------------

                                                    Hartsdale, NY 10530
                                            ------------------------------------

                                            ------------------------------------

                                        48.
<PAGE>

                                   SCHEDULE A
<TABLE>
<CAPTION>
------------------------------------------------------------ ---------------------------------------------------------
INVESTOR                                                     NUMBER OF SECURITIES
------------------------------------------------------------ ---------------------------------------------------------
<S>                                                          <C>
Advent Israel, L.P.                                          446,000 Shares of Series A Preferred Stock and 330,589
                                                             Shares of Series B Preferred Stock and 189,300 Shares
                                                             of Series C Preferred Stock

Advent International II, L.P.                                12,822 Shares of Series A Preferred Stock and 6,411
                                                             Shares of Series B Preferred Stock

Advent Israel Bermuda, L.P.                                  54,000 Shares of Series A Preferred Stock and 40,027
                                                             Shares of Series B Preferred Stock and 22,900 Shares of
                                                             Series C Preferred Stock

Advent Partners L.P.                                         38,850 Shares of Series B Preferred Stock and 9,450
                                                             Shares of Series C Preferred Stock

Noptek, L.P.                                                 641,026 Shares of Series A Preferred Stock and 481,560
                                                             Shares of Series B Preferred Stock and 273,650 Shares
                                                             of Series C Preferred Stock

------------------------------------------------------------ ---------------------------------------------------------
Peter Frederick and Jane Elizabeth Carpenter PTEE            142,858 Shares of Series D Preferred Stock
Carpenter 1985 Irrev Trust Dated 4/29/85, Jane Carpenter,
Trustee
------------------------------------------------------------ ---------------------------------------------------------
Chemicals and Materials Enterprise Associates, Limited       1,282,052 Shares of Series A Preferred Stock and
Partnership                                                  1,282,052 Shares of Series B Preferred Stock and
                                                             1,333,333 Shares of Series C Preferred Stock and
                                                             444,444 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Discount Investment Corporation Ltd.                         500,000 Shares of Series C Preferred Stock and 216,475
                                                             Shares of Series D Preferred Stock and 240,866 Shares
                                                             of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Eckenhoff Family Trust A, Bonnie J. Eckenhoff TREE 1/8/92    75,000 Shares of Series C Preferred Stock and 33,644
                                                             Shares of Series D Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
InterWest Investors VI, LP                                   88,791 Shares of Series C Preferred Stock and
                                                             16,913 Shares of Series D Preferred Stock and
                                                             6,756 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------

                                        49.
<PAGE>

------------------------------------------------------------ ---------------------------------------------------------
INVESTOR                                                     NUMBER OF SECURITIES
------------------------------------------------------------ ---------------------------------------------------------
InterWest Partners VI, L.P.                                  2,911,209 Shares of Series C Preferred Stock and
                                                             554,516 Shares of Series D Preferred Stock and 215,466
                                                             Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
INVESCO Funds Group, Inc.                                    1,142,858 Shares of Series D Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Pirate Ship & Co., Nominee of INVESCO Funds Group, Inc.      888,889 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Leeway & Co.                                                 1,437,960 Shares of Series D Preferred Stock and
                                                             266,667 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Ell & Co.                                                    2,276,326 Shares of Series D Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Gerlach  & Co., Nominee of The Manufacturers Life            2,714,286 Shares of Series D Preferred Stock
Insurance Company (USA)
------------------------------------------------------------ ---------------------------------------------------------
Merrill Lynch Pierce Fenner & Smith Inc. FBO David H.        28,572 Shares of Series D Preferred Stock
McCallum (IRA)
------------------------------------------------------------ ---------------------------------------------------------
David B. Musket                                              72,575 Shares of Series D Preferred Stock and 100,000
                                                             Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
David B. Musket SEP IRA c/o Cowen & Co., Custodian           50,000 Shares of Series C Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
PEC Israel Economic Corporation                              500,000 Shares of Series C Preferred Stock and 216,475
                                                             Shares of Series D Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
ProMed Partners, L.P.                                        150,000 Shares of Series D Preferred Stock and 46,125
                                                             Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Dr. Amram Rasiel                                             128,204 Shares of Series A Preferred Stock and 64,102
                                                             Shares of Series B Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Targa Capital                                                100,000 Shares of Series C Preferred Stock and 42,860
                                                             Shares of Series D Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Thomas E. Sparks, Jr.                                        25,000 Shares of Series C Preferred Stock and 10,824
                                                             Shares of Series D Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------

                                        50.
<PAGE>

------------------------------------------------------------ ---------------------------------------------------------
INVESTOR                                                     NUMBER OF SECURITIES
------------------------------------------------------------ ---------------------------------------------------------
U.S. Venture Partners IV, L.P.                               1,108,974 Shares of Series A Preferred Stock and
                                                             1,386,219 Shares of Series B Preferred Stock and
                                                             2,306,667 Shares of Series C Preferred Stock and
                                                             222,429 Shares of Series D Preferred Stock

Second Ventures II, L.P.                                     134,616 Shares of Series A Preferred Stock and 168,269
                                                             Shares of Series B Preferred Stock and 280,000 Shares
                                                             of Series C Preferred Stock and 27,000 Shares of Series
                                                             D Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
USVP Entrepreneur Partners II, L.P.                          38,462 Shares of Series A Preferred Stock and 48,077
                                                             Shares of Series B Preferred Stock and 80,000 Shares of
                                                             Series C Preferred Stock and 7,714 Shares of Series D
                                                             Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Venture Lending & Leasing, Inc.                              32,051 Shares of Common Stock and up to 52,000 Shares
                                                             of Series C Preferred Stock

Venture Lending & Leasing II, Inc.                           Up to 78,000 Shares of Series C Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Viridian Capital                                             400,000 Shares of Series D Preferred Stock and 333,333
                                                             Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Wheatley Partners, L.P.                                      526,798 Shares of Series D Preferred Stock and 819,463
                                                             Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Wheatley Foreign Partners, L.P.                              44,631 Shares of Series D Preferred Stock and 69,426
                                                             Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Alejandro C. Zaffaroni, Ph.D., & Lida Zaffaroni, Trustees    641,026 Shares of Series B Preferred Stock and 222,222
of the Zaffaroni Revocable Trust D/T/D 1-24-86               Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Zaffaroni Family Partnership, LP. (formerly Prydain          500,000 Shares of Series C Preferred Stock
Partners, L.P.)
------------------------------------------------------------ ---------------------------------------------------------
Jonathan Carpenter                                           24,013 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
PathoGenesis Corporation                                     961,539 Shares of Series E Preferred Stock
201 Elliott Avenue West, Suite 150
Seattle, WA  98118

------------------------------------------------------------ ---------------------------------------------------------

                                        51.
<PAGE>

------------------------------------------------------------ ---------------------------------------------------------
INVESTOR                                                     NUMBER OF SECURITIES
------------------------------------------------------------ ---------------------------------------------------------
Becton, Dickinson and Company                                961,539 Shares of Series E Preferred Stock
1 Becton Drive
Franklin Lakes, NJ  07417-1866

------------------------------------------------------------ ---------------------------------------------------------
MVI Medical Venture Investments Limited                      1,333,333 Shares of Series F Preferred Stock

------------------------------------------------------------ ---------------------------------------------------------
Edgemont Asset Management                                    888,889 Shares of Series F Preferred Stock

------------------------------------------------------------ ---------------------------------------------------------
Hunt Ventures, L.P.                                          444,444 Shares of Series F Preferred Stock

------------------------------------------------------------ ---------------------------------------------------------
The NeoMed Fund Limited                                      222,222 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Harris Venture Partners                                      222,222 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Valor Capital Management, L.P.                               222,222 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Kensington Partners, L.P.                                    86,076 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Bald Eagle Fund                                              19,625 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Kensington Partners, L.P. II                                 5,410 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
David Saks                                                   40,000 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
David Tuckerman                                              4,444 Shares of Series F Preferred Stock

------------------------------------------------------------ ---------------------------------------------------------
Matthew Frank                                                10,000 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Avery Ventures I                                             222,222 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Carpenter 1983 Family Trust UA dtd 3/9/83, Peter F.          44,444 Shares of Series F Preferred Stock
Carpenter and Jane Elizabeth Carpenter, Trustees
------------------------------------------------------------ ---------------------------------------------------------
Bonnie B. Dennis Living Trust                                20,000 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Barry Kurokawa IRA, Cowen & Co. Custodian                    23,000 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------
Barry Kurokawa                                               12,000 Shares of Series F Preferred Stock
------------------------------------------------------------ ---------------------------------------------------------

------------------------------------------------------------ ---------------------------------------------------------
</TABLE>

                                        52.

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