Document:

Filed by Automated Filing Services Inc. (604) 609-0244 - Medicure Inc. - Exhibit 4r

April 5, 2005 

 Mr. Albert D. Friesen 

  Medicure Inc. 

  1200 Waverley Street 

  4th Floor 

  Winnipeg, Manitoba 

  R3T 0P4 

Dear Dr. Friesen, 

 Re:        Arrangements on Change of
  Control 

 This letter confirms our agreement with respect to the amounts
  payable by Medicure Inc. (the Company”) to A.D. Friesen Enterprises Ltd.
  in the event that your employment as President and Chief Executive Officer of
  the Company is terminated or you resign from such position on or within 6 months
  after a “Change of Control of the Company”. 

	 1.      	 For the purposes of this agreement: 

	 
	 	 (a)     
      
	 “Change of Control of the Company” occurs
        (i) upon the acquisition by any person or group of persons acting jointly
        and in concert of more than 50% of the then issued and outstanding voting
        securities of the Company (or its successor by way of merger, amalgamation,
        arrangement or other corporate reorganization); or (ii) if during any
        period of two consecutive years, individuals who, at the beginning of
        such period constituted the board, together with any new director whose
        election by the board or nomination for election by the Company’s
        shareholders was approved by a vote of at least two-thirds of the directors
        then in office either who were directors at the beginning of the two-year
        period, or whose election or nomination was previously so approved, cease
        for any reason to constitute 60% of the board. 

	 
	 	 (b)      
	 “Compensation” means the sum of 200%
        of your annual base compensation in effect on the Occurrence of the Termination
        Event, an amount equal to 100% of the bonus, if any, paid to you
        with respect to the last completed fiscal year ending prior to the Occurrence
        of the Termination Event plus the amount, if any, of your annual car allowance
        in effect on the Occurrence of the Termination Event. 

 - 2 - 

	 	 (c)      
	 “Occurrence of the Termination Event”
        means the date of the termination or constructive termination of your
        employment or your voluntary resignation as President and Chief Executive
        Officer of the Company on or within 6 months after a Change of Control
        of the Company. 

	 
	 	 (d)      
	 “person” means an individual,
        corporation, company, partnership, unincorporated association, unincorporated
        syndicate, trust or other entity. 

	 
	 	 (e)      
	 The following presumptions apply to determine
        whether a person is “acting jointly and in concert” with any
        other person or group of persons: 

	 
	 	 	 (i)     
      
	 every person who, as a result of any agreement,
        commitment or understanding, whether formal or informal, with another
        person (such other person, the “offeror”) or any other person
        acting jointly or in concert with the offeror, acquires or offers to acquire
        securities of the Company of the same class as those acquired or offered
        to be acquired by the offeror; 

	 
	 	 	 (ii)      
	 every person who, as a result of any agreement,
        commitment or understanding, whether formal or informal, with the offeror
        or any other person acting jointly or in concert with the offeror intends
        to exercise jointly or to exercise jointly or in concert with the offeror
        or with any other person acting jointly or in concert with the offeror
        any voting rights attaching to any voting securities of the Company; and
      

	 
	 	 	 (iii)      
	 every associate or affiliate of the offeror (with
        the terms “associate” and “affiliate” having the
        respective meanings set out in the Securities Act (Ontario) as
        in effect on the date hereof). 

	 2.      	 Upon the Occurrence of a Termination Event, the
        Company shall pay to you a lump sum equal to the Compensation in satisfaction
        of any and all claims you may have against the Company for damages or
        otherwise for termination of employment except for your rights under sections
        3 and 4 below. 

	 
	 3.      	 In addition, upon the Occurrence of the Termination
        Event, you shall be entitled to continue, for 24 months from the
        Occurrence of the Termination Event, your participation in any group health
        and welfare plans of the Company then in effect, subject to the approval
        of the insurer, or if, as a result of such occurrence, you are no longer
        eligible to participate in such plans, you shall be reimbursed, for such
        24 month period, for costs incurred by you in obtaining and participating
        in substantially equivalent replacement plans, if any, in either case
        only until such time as you obtain alternative or new employment. 

	 
	 4.      	 Upon the Occurrence of the Termination Event, any
        options held by you to purchase shares in the Company shall remain in
        full force and effect until expiry thereof in accordance with the terms
        of the certificates or agreements under which such options or 

 - 3 - 

	 	 warrants were granted and all unvested options shall
        immediately vest and remain in full force and effect for 60 days following
        the Occurrence of the Termination Event. 

	 
	 5.      	 Nothing contained herein shall release you from
        any obligations you have as a fiduciary of the Company whether arising
        before or after the Occurrence of the Termination Event. 

	 
	 6.      	 You agree that, after the Occurrence of the Termination
        Event, you will not make any disparaging remarks or comments concerning
        the Company and its business and affairs. 

	 
	 7.      	 This agreement shall be governed by and construed
        in accordance with the laws of the Province of Manitoba. 

	 
	 8.      	 This agreement shall enure to the benefit of and
        be binding upon you and your heirs, executives, administrators and legal
        personal representatives and upon the Company and its successors. 

 If you are in agreement with the foregoing, please so indicate
  by signing the duplicate copy of this letter and returning it to the undersigned.

Yours very truly, 

 Medicure Inc. 

 

 By: /s/ Derek Reimer 

 

	 Accepted and Agreed:  	  
	 	 
	 April 5, 2005  	  
	 	 
	 /s/ Albert D. Friesen  	 /s/ Dawson Reimer  
	  	 WitnessFiled by Automated Filing Services Inc. (604) 609-0244 - Medicure Inc. - Exhibit 4s

April 5, 2005 

Mr. Moray Merchant 

 Medicure Inc. 

  1200 Waverley Street 

  4th Floor 

  Winnipeg, Manitoba 

  R3T 0P4 

Dear Mr. Merchant, 

 Re:        Arrangements on Change of
  Control 

 This letter confirms our agreement with respect to the amounts
  payable by Medicure Inc. (the Company”) to you in the event that your
  employment as Vice President Market and Business Development of the Company
  is terminated or you resign from such position on or within 6 months after a
  “Change of Control of the Company”. 

	 1.      	 For the purposes of this agreement: 

	 
	 	 (a)     
      
	 “Change of Control of the Company” occurs
        (i) upon the acquisition by any person or group of persons acting jointly
        and in concert of more than 50% of the then issued and outstanding voting
        securities of the Company (or its successor by way of merger, amalgamation,
        arrangement or other corporate reorganization); or (ii) if during any
        period of two consecutive years, individuals who, at the beginning of
        such period constituted the board, together with any new director whose
        election by the board or nomination for election by the Company’s
        shareholders was approved by a vote of at least two-thirds of the directors
        then in office either who were directors at the beginning of the two-year
        period, or whose election or nomination was previously so approved, cease
        for any reason to constitute 60% of the board. 

	 
	 	 (b)      
	 “Compensation” means the sum of 100%
        of your annual base compensation in effect on the Occurrence of the Termination
        Event, an amount equal to 100% of the bonus, if any, paid to you
        with respect to the last completed fiscal year ending prior to the Occurrence
        of the Termination Event plus the amount, if any, of your annual car allowance
        in effect on the Occurrence of the Termination Event. 

 - 2 - 

	 	 (c)      	 “Occurrence of the Termination Event”
        means the date of the termination or constructive termination of your
        employment or your voluntary resignation as Vice President Market and
        Business Development of the Company on or within 6 months after a Change
        of Control of the Company. 

	 
	 	 (d)      	 “person” means an individual,
        corporation, company, partnership, unincorporated association, unincorporated
        syndicate, trust or other entity. 

	 
	 	 (e)      	 The following presumptions apply to determine
        whether a person is “acting jointly and in concert” with any
        other person or group of persons: 

	 
	 	 	 (i)     
      
	 every person who, as a result of any agreement,
        commitment or understanding, whether formal or informal, with another
        person (such other person, the “offeror”) or any other person
        acting jointly or in concert with the offeror, acquires or offers to acquire
        securities of the Company of the same class as those acquired or offered
        to be acquired by the offeror; 

	 
	 	 	 (ii)      
	 every person who, as a result of any agreement,
        commitment or understanding, whether formal or informal, with the offeror
        or any other person acting jointly or in concert with the offeror intends
        to exercise jointly or to exercise jointly or in concert with the offeror
        or with any other person acting jointly or in concert with the offeror
        any voting rights attaching to any voting securities of the Company; and
      

	 
	 	 	 (iii)      
	 every associate or affiliate of the offeror (with
        the terms “associate” and “affiliate” having the
        respective meanings set out in the Securities Act (Ontario) as
        in effect on the date hereof). 

	 2.      	 Upon the Occurrence of a Termination Event, the
        Company shall pay to you a lump sum equal to the Compensation in satisfaction
        of any and all claims you may have against the Company for damages or
        otherwise for termination of employment except for your rights under sections
        3 and 4 below. 

	 
	 3.      	 In addition, upon the Occurrence of the Termination
        Event, you shall be entitled to continue, for 12 months from the
        Occurrence of the Termination Event, your participation in any group health
        and welfare plans of the Company then in effect, subject to the approval
        of the insurer, or if, as a result of such occurrence, you are no longer
        eligible to participate in such plans, you shall be reimbursed, for such
        12 month period, for costs incurred by you in obtaining and participating
        in substantially equivalent replacement plans, if any, in either case
        only until such time as you obtain alternative or new employment. 

	 
	 4.      	 Upon the Occurrence of the Termination Event, any
        options held by you to purchase shares in the Company shall remain in
        full force and effect until expiry thereof in accordance with the terms
        of the certificates or agreements under which such options or 

 - 3 - 

	 	 warrants were granted and all unvested options shall
        immediately vest and remain in full force and effect for 60 days following
        the Occurrence of the Termination Event. 

	 
	 5.      	 Nothing contained herein shall release you from
        any obligations you have as a fiduciary of the Company whether arising
        before or after the Occurrence of the Termination Event. 

	 
	 6.      	 You agree that, after the Occurrence of the Termination
        Event, you will not make any disparaging remarks or comments concerning
        the Company and its business and affairs. 

	 
	 7.      	 This agreement shall be governed by and construed
        in accordance with the laws of the Province of Manitoba. 

	 
	 8.      	 This agreement shall enure to the benefit of and
        be binding upon you and your heirs, executives, administrators and legal
        personal representatives and upon the Company and its successors. 

 If you are in agreement with the foregoing, please so indicate
  by signing the duplicate copy of this letter and returning it to the undersigned.

Yours very truly, 

 Medicure Inc. 

 

	 By: /s/ Albert D. Friesen  	  
	  	 
	 	 
	 	 
	 Accepted and Agreed:  	  
	 	 
	 April 5, 2005  	  
	 	 
	 /s/ Moray Merchant  	 /s/ Derek Reimer  
	  	 Witness

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00090-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00090-of-00352.parquet"}]]