Document:

May 14, 2001

Bradley Carver
President & CEO
SafeScience, Inc.
31 St. James Ave., 8th Floor
Boston, MA  02116

RE:      Amendment #1

Dear Brad:

As recently discussed with Brian Hughes and John Burns, Wayne State University
("WSU"), Barbara Ann Karmanos Cancer Institute ("KCI") (together, "Licensors")
and SafeScience, Inc. ("Company") desire to effect the following amendment to
the WSU-KCI-Company License Agreement effective January 26, 2001 (the
"Agreement"):

1. Section 3.1 (c) of the Agreement shall be amended and shall read in full as
follows: "Licensee shall pay Licensors an additional license fee which shall
constitute five percent (5%) of cash raised directly or indirectly for the
benefit of Licensee, by Licensee or any entity affiliated in whole or in part
with Licensee, and whether through debt, equity, or other means during the term
of this Agreement. Such additional fee shall be paid in quarterly installments
within forty-five (45) days of the end of each calendar quarter, with each
quarterly installment payment constituting five percent (5%) of cash raised
directly or indirectly for the benefit of Licensee, by Licensee or any entity
affiliated in whole or in part with Licensee, and whether through debt, equity,
or other means during the immediately preceding calendar quarter. Once Licensee
has raised at least $3,000,000 in cash raised directly or indirectly for the
benefit of Licensee, by Licensee or any entity affiliated in whole or in part
with Licensee, and whether through debt, equity, or other means during the term
of this Agreement, Licensee shall have twelve (12) months to raise an additional
$29,700,000. In the event $29,700,000 are not raised within such twelve (12)
month time period, Licensee shall make payment within forty five (45) days of
the end of such 12 month period such that the total payments made under this
paragraph are $1,635,000. If the Licensee raises less than $3,000,000 cash
raised directly or indirectly for the benefit of Licensee, by Licensee or any
entity affiliated in whole or in part with Licensee, and whether through debt,
equity, or other means during the term of this Agreement the Licensee shall owe
no more nor no less than 5% of the cash raised. If the Licensee raises at least
$3,000,000 cash raised directly or indirectly for the benefit of Licensee, by
Licensee or any entity affiliated in whole or in part with Licensee, and whether
through debt, equity, or other means during the term of this Agreement, total
payments under this paragraph shall not exceed $1,635,000."

2. Section 6.2 (f) of the Agreement shall be amended to delay the date on which
Licensors can invoke their right to terminate the Agreement in the event
Licensee is involuntarily delisted from the Nasdaq stock exchange. As amended,
Section 6.2 (f) shall read in full as follows: "Beginning September 1, 2001,
Licensors may, at their option, terminate this Agreement and revoke the license
granted in Sections 2.1 and 2.2. in the event Licensee is involuntarily delisted
from the Nasdaq stock

<PAGE>

exchange for reasons of failure to comply with the listing requirements under
NASD Market Place Rule 4310(c)(2), (4) or (7), provided, however, that Licensors
shall have no right to terminate this Agreement, except as provided in Sections
6.2 (a-c), once Licensee has entered into an agreement to sell Licensed Products
with a pharmaceutical or biotechnology company having a net worth of at least
$100 million or market capitalization of at least $200 million; furthermore,
Licensors shall have no right to terminate this Agreement, except as provided in
Sections 6.2 (a-c), during any time period when (i) Licensee has at least a
total of $10 million in cash and cash equivalents on its balance sheet as
certified by Licensee's chief financial officer and Licensee's financial
obligations do not exceed such amount, or (ii) Licensee's closing stock price on
the Nasdaq SmallCap Market, Nasdaq National Market, New York Stock Exchange or
American Stock Exchange is at least $5.00 per share."

3. The second sentence of Section 2.6 of the Agreement shall be amended to read
in full as follows: Determination of diligence shall be made with reference to
objective criteria, including, without limitation, Licensee's obligation to (i)
raise at least three million dollars ($3,000,000.00) in cash through the
issuance of securities, including but not limited to debt or equity, between the
Effective Date and October 1, 2001; and (ii) introduce Licensed Products to the
market within six (6) months following receipt of necessary marketing approvals
from the Food and Drug Administration ("FDA") and other appropriate regulatory
agencies.

4. Except as expressly amended by this Amendment #1, all other terms and
provisions of the Agreement shall remain in full force and effect (including
Section 9.6 (Counterparts). Capitalized terms used in this Amendment #1 and not
defined herein are used with the meaning ascribed to them in the Agreement. This
Amendment #1 shall take effect as of January 26, 2001.

If the terms of this Amendment No. 1 are agreeable to Company, please have two
copies of Amendment No. 1 executed on behalf of Company and forward them to my
attention for signature on behalf of WSU.

                                            Very truly yours,

                                            /s/ Fred Reinhart

                                            Fred Reinhart

<PAGE>

AGREED AND ACCEPTED:

SAFESCIENCE, INC.                            WAYNE STATE UNIVERSITY

By:     /s/ Bradley J. Carver                By:    /s/ Fred Reinhart
      -----------------------                      -----------------------------
Name:   Bradley J. Carver                    Name:  Fred Reinhart
      -----------------------                      -----------------------------
Title:  CEO and President                    Title: Director Technology Transfer
      -----------------------                      -----------------------------
                                                    Office
                                                   -------

BARBARA ANN KARMANOS CANCER INSTITUTE

By:      /s/ William G. Bennet
     ---------------------------
Name:    William G. Bennet
     ---------------------------
Title:   Chief Financial Officer
     ---------------------------================================================================================

                           FOURTH AMENDMENT AGREEMENT

                            DATED AS OF MAY 17, 2001

                                      AMONG

                           LILLIAN VERNON CORPORATION,

                                  AS BORROWER,

                   LILLIAN VERNON FULFILLMENT SERVICES, INC.,

                           LVC RETAIL CORPORATION AND

                       LILLIAN VERNON INTERNATIONAL, LTD.

                                 AS GUARANTORS,

                            THE CHASE MANHATTAN BANK,

                                    AS AGENT,

                                       AND

                             THE BANKS NAMED HEREIN

                            ------------------------

               TO THE CREDIT AGREEMENT DATED AS OF AUGUST 19, 1996

                            -------------------------

================================================================================

<PAGE>

     THIS FOURTH AMENDMENT AGREEMENT, dated as of May 17, 2001 (this "Fourth
Amendment"), among LILLIAN VERNON CORPORATION, a Delaware corporation (the
"Borrower"), LILLIAN VERNON FULFILLMENT SERVICES, a Virginia corporation
("LVFS"), LVC RETAIL CORPORATION, a Delaware corporation ("LVC"), and LILLIAN
VERNON INTERNATIONAL, LTD., a New York corporation ("LVI Inc.", and together
with LVFS and LVC, the "Guarantors"), the several banks from time to time
parties to the Agreement (as defined below) (the "Banks") and THE CHASE
MANHATTAN BANK, a New York banking corporation, as agent for the Banks hereunder
(in such capacity, the "Agent");

                              W I T N E S S E T H :
                              ---------------------

          WHEREAS, the parties hereto have entered into a Revolving Credit
Agreement dated as of August 19, 1996 (as amended, restated, supplemented or
otherwise modified from time to time, the "Agreement");

          WHEREAS, the Borrower has requested the Banks amend the Agreement as
of the date hereof (the "Fourth Amendment Effective Date") in order to extend
the Maturity Date to August 31, 2005 and adjust certain financial covenants
contained therein; and

          WHEREAS, the Borrower and Guarantors desire, and each Bank and the
Agent are willing, on the terms and conditions set forth below, to modify
certain terms of the Agreement as set forth below;

          NOW, THEREFORE, in consideration of the premises and mutual covenants
herein contained, the parties hereto hereby agree as follows:

     SECTION 1. DEFINED TERMS. Capitalized terms used herein and not defined
herein shall have the meanings specified in the Agreement.

     SECTION 2. AMENDMENTS TO THE AGREEMENT.

          (A) Section 1.01 of the Agreement is hereby amended by deleting the
definition of "Maturity Date" contained therein and inserting in lieu thereof
the following:

          "'Maturity Date' shall mean August 31, 2005."

          (B) Section 2.10(c) of the Agreement is hereby amended by inserting
beneath the headings "Conversion Date" and "Maximum Term" and immediately after
the entries "prior to August 19, 2000" and "3 years", respectively, the
following:

          "prior to August 31, 2002          6 years
           prior to August 31, 2003          5 years
           prior to August 31, 2004          4 years
           prior to August 31, 2005          3 years"

          (C) Section 6.10 of the Agreement is hereby amended by deleting such

<PAGE>

Section in its entirety and inserting in lieu thereof the following:

                    "SECTION 6.10. Consolidated Capital Expenditures. Permit,
          during each of the fiscal years specified below, Consolidated Capital
          Expenditures to exceed in the aggregate the sum of (i) the maximum
          amount set forth below opposite such fiscal year, plus (ii) the actual
          amount of the maximum amount set forth below that was not expended for
          Consolidated Capital Expenditures during the immediately preceding
          fiscal year:

                         Fiscal Year                 Maximum Amount
                         -----------                 --------------
                           2001                      $ 5,000,000
                           2002                      $10,000,000
                           2003                      $10,000,000
                           2004                      $10,000,000
                           2005                      $10,000,000"

          (D) Section 6.12 of the Agreement is hereby amended by deleting such
Section in its entirety and inserting in lieu thereof the following:

                    "SECTION 6.12. Consolidated Working Capital. Permit the
          Consolidated Working Capital to be less than (a) $55,000,000 at the
          end of each fiscal year and at the end of the first quarter of each
          fiscal year, (b) $45,000,000 at the end of the second quarter of each
          fiscal year and (c) $35,000,000 at the end of the third quarter of
          each fiscal year."

                    (E) Section 6.14 of the Agreement is hereby amended by
          deleting such Section in its entirety and inserting in lieu thereof
          the following:

                    "SECTION 6.14. Consolidated Tangible Net worth Plus
          Subordinated Debt. At any time permit the sum of Consolidated Tangible
          Net Worth plus Subordinated Debt to be less than (a) $90,000,000
          during the first and second quarters of each fiscal year and (b)
          $95,000,000 during the third and fourth quarters of each fiscal year."

          SECTION 3. CONDITIONS TO EFFECTIVENESS. This Fourth Amendment shall
become effective only upon the satisfaction or waiver of all of the following
conditions precedent:

          (A) The parties hereto shall have duly executed and delivered this
Fourth Amendment.

          (B) The Agent shall have received certificates of the Secretary or
Assistant Secretary of the Borrower and each of the Guarantors dated as of the
Fourth Amendment Effective Date, certifying: (i) that its respective By-laws
either are attached to such certificate, or to the extent not attached have not
been amended since the Closing Date, (ii) that its respective charter or
certificate, as the case may be, either is attached to such certificate or to
the extent not attached has not been amended since the Closing Date, and (iii)
as to the incumbency and signatures of

                                       2

<PAGE>

each of its respective officers executing this Fourth Amendment and any other
documents to which it is a party.

          (C) The Agent shall have received from the Borrower the fees and
expense reimbursements referred to under Section 7 hereof.

          SECTION 4. REPRESENTATIONS AND WARRANTIES. In order to induce the
Banks and Agent to enter into this Fourth Amendment, the Borrower and the
Guarantors hereby jointly and severally represent and warrant to the Agent: (i)
that the representations and warranties contained in the Agreement are true and
correct on and as of the Fourth Amendment Effective Date as though made on and
as of such date, except for changes which have occurred and which were not
prohibited by the terms of the Agreement; (ii) that no Default or Event of
Default has occurred and is continuing, or would result from the execution,
delivery and performance by the Borrower and the Guarantors, of this Fourth
Amendment or the Agreement (as amended by this Fourth Amendment); (iii) that the
Borrower and the Guarantors have full power, right and legal authority to
execute, deliver and perform its obligations under this Fourth Amendment; (iv)
that the Borrower and Guarantors have taken all action necessary to authorize
the execution and delivery of, and the performance of its obligations under this
Fourth Amendment; and (v) that each of this Fourth Amendment and the Agreement
(as amended by the Fourth Amendment) constitutes a legal, valid and binding
obligation of the Borrower and the Guarantors enforceable against each of them
in accordance with its terms, subject to the effect of any applicable
bankruptcy, insolvency, reorganization or moratorium or similar laws affecting
the rights of creditors generally and by general equitable principles (whether
enforcement is sought by proceedings in equity or at law).

          SECTION 5. GUARANTY. The Guarantors each acknowledge receipt of a copy
of this Fourth Amendment Agreement and hereby ratify and affirm their guaranty
of the Obligations of the Borrower under the Agreement as amended hereby.

          SECTION 6. REFERENCE TO AND EFFECT ON THE DOCUMENTS. Each reference in
the Agreement to "this Agreement", "hereunder", "hereof", "herein" or words of
like import, and each reference to the Agreement in documents related to the
Agreement, shall mean and be a reference to the Agreement as amended hereby.
Except as specifically amended hereby, the Agreement and all such related
documents, and all other documents, agreements, instruments or writings entered
into in connection therewith, shall remain in full force and effect and are
hereby ratified, confirmed and acknowledged by the Borrower.

          SECTION 7. FEES AND EXPENSES. The Borrower agrees to pay or reimburse
the Agent, as stated in Section 10.05 of the Agreement (as amended hereby), for
its reasonable out-of-pocket costs and expenses, including, without limitation,
the reasonable fees and disbursements of counsel to the Agent incurred by the
Agent in connection with the preparation, reproduction, execution and delivery
of this Fourth Amendment and any other instruments and documents to be delivered
hereunder. In addition, the Borrower agrees to pay to the Banks, through the
Agent, on the Fourth Amendment Effective Date, a facility fee in an amount equal
to $25,000, to be shared pro rata among the Banks based upon the Tranche 1
Commitments.

                                       3

<PAGE>

          SECTION 8. GOVERNING LAW. This Fourth Amendment and the rights and
obligations of the parties hereunder shall be governed by and construed and
interpreted in accordance with the substantive laws of the State of New York,
without regard to its conflict of laws principles.

          SECTION 9. COUNTERPARTS. This Fourth Amendment may be executed in any
number of counterparts, all of which taken together shall constitute one and the
same instrument, and any party hereto may execute this Fourth Amendment by
signing any such counterpart.

                                       4

<PAGE>

          IN WITNESS WHEREOF, the parties hereto have caused this Fourth
Amendment to be duly executed and delivered by their proper and duly authorized
officers as of the day and year first above written.

                                      THE CHASE MANHATTAN BANK,
                                      As Bank and as Agent,

                                      By:
                                         ----------------------------------
                                         Name:
                                         Title:

                                      SUNTRUST BANK

                                      By:
                                         ----------------------------------
                                         Name:
                                         Title:

                                       5

<PAGE>

                       SIGNATURE PAGE TO FOURTH AMENDMENT
                       TO LILLIAN VERNON CREDIT AGREEMENT

                                           LILLIAN VERNON CORPORATION

                                           By:
                                              ---------------------------------
                                              Name:
                                              Title:

                                           LILLIAN VERNON FULFILLMENT
                                           SERVICES, INC.

                                           By:
                                              ---------------------------------
                                              Name:
                                              Title:

                                           LVC RETAIL CORPORATION

                                           By:
                                              ---------------------------------
                                              Name:
                                              Title:

                                           LILLIAN VERNON INTERNATIONAL, INC.

                                           By:
                                              ---------------------------------
                                              Name:
                                              Title:

                                       6

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