Document:

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                                                                EXHIBIT 10.18

                                [Logo]

March 1, 1995

Paul H. Fischer, Ph.D.
15310 Kwanzan Court
N. Potomac, Maryland 20878

Dear Paul:

It is with great pleasure that i extend an offer of employment to you for the
position of Vice President of Research and Development, a position which
reports directly to the President of GenVec, Inc. We were all very impressed
with your backround and experience and have every confidence that you would
be an extremely valuable addition to our Management Team.

The specific terms of this offer are detailed in the enclosed schedule. I
believe that you will find these terms to be consistent with those discussed
during our recent conversations. As you will see, I have listed your start
date as "To be determined". We would be anxious for you to join us as soon as
possible, but the exact start date can be agreed upon later.

I have also enclosed two (2) copies of the GenVec Confidentiality, Invention,
and Non-Compete Agreement that must be signed by each GenVec employee. Please
feel free to review this document and call me with any questions.

I know that you are as excited about the opportunities at GenVec as I am.
We are all looking forward to working with you and gaining the benefit of
your extensive experience. Together, we will certainly be able to build a
stronger, more valuable company.

If the terms of this offer are acceptable to you, please sign and date both
copies of this letter and the Confidentiality, Invention and Non-Compete
Agreement, keep one of each for yourself and return the other to me.

Sincerely,

/s/ Thomas W. D'Alonzo
Thomas W. D'Alonzo
President & Chief Executive Officer

enclosures

AGREED TO AND ACCEPTED BY:

/s/ Paul H. Fischer, Ph.D.                           March 9, 1995
--------------------------                           -------------------
Paul H. Fischer, Ph.D.                               Date

<PAGE>

                                  GENVEC, INC.

                               TERMS OF EMPLOYMENT

Employee
Name:          Paul H. Fischer, Ph.D.

Position:      Vice President of Research and Development

Start Date:    March 1, 1995

Salary:        $170,000 per annum, to be paid in semi-monthly installments

Equity:        You will be awarded options to purchase 475,000 shares of
               common stock at a price of $0.10 per share, as follows:

               - 425,000 shares vesting equally over a four year period

               - 25,000 shares for each of your first two years of employment
                 at GenVec, vesting based on the achievement of agreed upon
                 milestones during those periods.

Salary
Continuation:  Should your employment be terminated for any reason other than
               for cause, your salary shall continue to be paid for a period
               of nine (9) months from the effective date of such termination.
               Payments made hereunder would cease if you become permanently
               employed at the same or greater salary during the nine month
               period.

Vacation:      Three (3) weeks annual vacation.

Holidays:      Seven paid holidays plus three paid floating holidays.

Medical
Insurance:     The Company will provide health and dental insurance through
               its group policy with Aetna. The Company splits the cost of
               this plan 80/20 with the employee. A family plan currently
               costs the employee $112.33 per month through payroll
               deductions.

Disability
Insurance:     The first 90 days of short term disability is covered by the
               Company at 80% of pay until after two years of service. After
               two years, the first 90 days will be paid at 100% of salary.
               After 90 days, long term disability will pay 60% of salary,
               with a maximum monthly payment of $5,000.

<PAGE>

401(k)
Plan:         The Company allows all employees with six months of service and
              21 years of age to participate in its 401(k) plan. Employees may
              contribute, on a pretax basis, the lesser of 15% of their salary
              or $9,240. The plan is subject to all IRS compliance
              regulations.

Other
Benefits:     The Company will insure you when traveling on business up to
              $250,000. Basic life insurance of $50,000 is also provided. You
              will be included in other benefit programs which may be
              established by the Company, consistent with your position within
              the Company.<PAGE>
                                                           EXHIBIT 10.19

                                PRINCE VENTURES

June 3, 1993

Imre Kovesdi, Ph.D.
160A South Main Street
Pearl River, NY 10965-2433

VIA FEDERAL EXPRESS

Dear Imre:

I very much enjoyed having dinner with you last night at Aria in Manhattan.
The fact that you enjoy opera as much as I do perhaps made the restaurant an
ideal choice. I was pleased to describe the financial aspects of venture
capital, IPOs, stock options, etc. I was also pleased to introduce you to my
firm and our Scientific Advisory Board. I am extremely excited about the
opportunity GenVec represents, as you know, and feel that you will be a
strong contributor to the eventual success of GenVec. I especially would like
you to join us as soon as possible so that our scientific recruiting can
embody some of the staffing concepts you and I discussed over dinner.

I am pleased to be able to significantly improve our offer to you for the
position of Director - Vector Biology and Development.

In simplistic terms, the near term goals of the company are:

     1.  Construct a 2nd generation CF adenovector system which is enough of
         an improvement over the existing design to:

         a.  warrant use of this vector in follow-on human CF trials

         b.  justify patent filings and be FDA approved based on improved
             efficacy/safety profile

     2.  Prioritize clinical targets for applications beyond CF

     3.  Construct next generation proprietary generic vectors which confer
         significant advantages over existing designs preferably optimized
         for use in the applications identified in #2. A partial list of
         areas to be explored would include

         a.  immune blunting
         b.  increasing longevity of expression
         c.  tropism
         d.  tissue specific promotion and radiation inducible promotion
         e.  improved production methods to increase safety
         f.  others

<PAGE>

                                     - 2 -

You would be expected to significantly contribute to growing an organization
capable of reaching the above goals. Input is also desired and expected on
organization design, identification and recruitment of new hires and
laboratory set-up and design.

The expectations are to have a scientific  staff (scientist and research
associates) of approximately 12 people within 12-18 months and a total of 25
within 24-30 months. Additional scientific support will come from Ron
Crystal's academic lab at Cornell and from the collaboration with Genentech
in the CF area.

DETAILS OF OFFER

     Annual salary: $100,000 per year, guaranteed for 12 months

     Sign-on Bonus: $10,000, paid upon acceptance of offer

     Incentive stock options: 60,000 shares with 4 year vesting schedule, at
     $.10/share exercise price

     Benefits: medical and dental insurance for you and your wife

     Relocation package:

          -  up to $6,420 to cover the cost of being released from you
             current lease in Pearl River (depending on you best efforts
             negotiation with your present landlord)

          -  mortgage points and closing costs should you and your wife
             decide to purchase a house in the Rockville/Gaithersburg area

          -  temporary living expenses up to three months

          -  out of pocket moving expenses

     Professional enhancements:

          -  personal research may be done at GenVec (up to 10% of workday)

          -  an adjunct professorship will be arranged if possible at the NIH
             or other suitable institution

     Offer expiration: June 10, 1993

Imre, I hope this offer meets with your approval. Please call me at my
office (203-227-8332) or my home (203-431-0649) if you or your wife have any
questions.

As we discussed, I would like to invite you and your wife to visit the D.C.
area at our expense and give you a sense of the many benefits and attractions
of the area. We are working with relocation experts who would be pleased to
give you detailed tours and provide you with a wealth of information about
the area. Ron Crystal and his wife Janet would be pleased to have dinner with
you and your wife while you are there.

<PAGE>

                                     - 3 -

Again, I welcome you to join us in what I know will be a very exciting,
challenging, and rewarding opportunity, both professionally and financially.
I look forward to hearing from you. Please signify your acceptance of our
offer by signing and returning to me one copy of this letter.

Sincerely,

/s/ Gregory F. Zaic
Gregory F. Zaic
Chairman, GenVec Inc.

ACCEPTED

/s/ Imre Kovesdi, Ph.D.
Imre Kovesdi, Ph.D.

June 6, 1993

cc: John Ruhmann<PAGE>

                                                         EXHIBIT 10.20

                                  [cad 157]Logo[cad 179]

March 7, 1995

Thomas E. Smart
3748 Bret Harte Drive
Redwood City, CA 94061

Dear Tom:

It is with great pleasure that I extend an offer of employment to you for the
position of Executive Director, Corporate Development at GenVec, Inc. We were
all very impressed with your background and experience and have every
confidence that you would be an extremely valuable addition to our Management
Team.

The specific terms of this offer are detailed in the enclosed schedule. I
believe that you will find these terms to be consistent with those discussed
during our recent conversations. As you will see, I have listed your start
date as "To be determined". We would be anxious for you to join us as soon as
possible, but the exact start date can be agreed upon later.

I have also enclosed two (2) copies of the GenVec Confidentiality, Invention,
and Non-Compete Agreement that must be signed by each GenVec employee. Please
feel free to review this document and call me with any questions.

I know that you are as excited about the opportunities at GenVec as I am. We
are all looking forward to working with you and gaining the benefit of your
extensive experience. Together, we will certainly be able to build a
stronger, more valuable company.

If the terms of this offer are acceptable to you, please sign and date both
copies of this letter and the Confidentiality, Invention and Non-Compete
Agreement, keep one of each for yourself and return the other to me.

Sincerely,

/s/ Thomas W. D'Alonzo
Thomas W. D'Alonzo
President & Chief Executive Officer

enclosures

AGREED TO AND ACCEPTED BY:

/s/ Thomas E. Smart                 3/9/95
------------------------------      -----------------------------
Thomas E. Smart                     Date

<PAGE>

                                 GENVEC, INC.

                             TERMS OF EMPLOYMENT

Employee
Name:          Thomas E. Smart

Position:      Executive Director, Corporate Development
               (Vice President title will immediately follow the execution of
               an additional corporate collaboration)

Start Date:    To be determined

Salary:        $110,000 per annum, to be paid in semi-monthly installments

Bonus:         $10,000 upon the signing of a corporate collaboration
               agreement within 12 months of employment and an additional
               $10,000 upon the signing of a second corporate collaboration
               agreement within 18 months of employment. Each of these
               corporate collaborations is expected to include material up
               front payments, annual research support, milestones and
               royalties on future product sales.

Equity:        You will be awarded options to purchase 225,000 shares of
               common stock at a price of $0.10 per share, as follows:

               -  180,000 shares vesting equally over a four year period

               -  10,000 shares vesting upon the signing each of the two
                  significant corporate partnerships described above in the
                  "Bonus" section.

               -  25,000 shares vesting over four years beginning on the date
                  of your promotion to Vice President.

               Should a "change in control", as described in the attached
               definition, occur at GenVec during your employment, all
               options which are not yet vested will immediately become fully
               vested.

Relocation:    The Company will reimburse you for moving expenses up to a
               maximum of $40,000, which are incurred during the first twelve
               (12) months of your employment, including the following:

                    -  Estimated closing fee on your California residence
                       of $15,000.
                    -  Transfer taxes on your California residence of $5,000.
                    -  One house hunting trip, if necessary.
                    -  Temporary housing costs for up to 30 days, if necessary.
                    -  Transportation of all personal property.
                    -  Other mutually agreed upon misc. relocation expenses.

               (It is expected that expenses will not exceed $30,000.) To the
               extent that these expenses are not tax deductible, the Company
               will gross them up for all federal and state personal income
               taxes.

<PAGE>

Salary
Continuation:  Should your employment be terminated for any reason other than
               for cause, your salary shall continue to be paid for a period
               of six (6) months from the effective date of such termination.
               Payments made hereunder would cease if you become permanently
               employed at the same or greater salary during the nine month
               period.

Vacation:      Three (3) weeks annual vacation

Holidays:      Seven paid holidays plus three paid floating holidays.

Medical
Insurance:     The Company will provide health and dental insurance through
               its group policy Aetna. The Company splits the cost of this
               plan 80/20 with the employee. A family plan currently costs
               the employee $112.33 per month through payroll deductions.

Disability
Insurance:     The first 90 days of short term disability is covered by the
               Company at 80% of pay until after two years of service. After
               two years, the first 90 days will be paid at 100% of salary.
               After 90 days, long term disability will pay 60% of salary,
               with a maximum monthly payment of $5,000.

401(k)
Plan:          The Company allows all employees with six months of service and
               21 years of age to participate in its 401(k) plan. Employees
               may contribute, on a pretax basis, the less of 15% of their
               salary or $9,240. The plan is subject to all IRS compliance
               regulations.

Other
Benefits:      The Company will insure you when traveling on business up to
               $250,000. Basic life insurance of $50,000 is also provided.
               You will be included in other benefit programs which may be
               established by the Company, consistent with your position
               within the Company.

<PAGE>

                      DEFINITION OF "CHANGE IN CONTROL"

A  "Change in Control" shall mean the earliest to occur of the following events:

(i)    the date the stockholders of the Company (or the Board of Directors, if
       stockholder action is not required) approve a plan or other arrangement
       pursuant to which the Company will be dissolved or liquidated; or

(ii)   the date the stockholders of the Company (or the Board of Directors,
       if stockholder action is not required) and the stockholders of the
       other constituent corporation, if applicable, (or its board of
       directors, if stockholder action is not required) have approved a
       definitive agreement to sell or otherwise dispose of substantially all
       of the assets of the Company, other than in a transaction in which
       shareholders of the Company will maintain voting control of the
       purchasing entity after the transaction; or

(iii)  the date the stockholders of the Company (or the Board of Directors,
       if stockholder action is not required) and the stockholders of the
       other constituent corporation, if applicable, (or its board of
       directors, if stockholder action is not required) have approved a
       definitive agreement to reorganize, merge or consolidate the Company
       with or into such corporation, other than, in either case, a
       reorganization, merger, or consolidation of the Company, in a
       transaction in which shareholders of the Company will maintain voting
       control of the surviving entity after the transaction; or

(iv)   The date any entity, person or group, other than the Company or any of
       its subsidiaries and other than an entity which is not engaged in the
       operation of a trade or business involving research and development or
       the sale of goods and services, shall have become the beneficial owner
       of, or shall have obtained voting control over more than fifty percent
       (50%) of the outstanding shares of the Company's common stock.

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