Document:

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                                                                    EXHIBIT 10.4

                                                               EXECUTION VERSION

              AMENDMENT TO AMENDED AND RESTATED BINDING TERM SHEET

      This AMENDMENT TO AMENDED AND RESTATED BINDING TERM SHEET (this
"AMENDMENT") is made effective as of December 27, 2004 by and between NORTHWEST
BIOTHERAPEUTICS, INC., a Delaware corporation (the "COMPANY"), and TOUCAN
CAPITAL FUND II, L.P., a Delaware limited partnership ("TOUCAN").

                                    RECITALS

      WHEREAS, the Company and Toucan are party to that certain Binding
Convertible Preferred Stock Term Sheet originally dated April 26, 2004 and
amended and restated on October 22, 2004 (as so amended and restated, the
"CONVERTIBLE PREFERRED STOCK TERM SHEET").

      WHEREAS, concurrently herewith, the Company and its affiliates, if any,
and Toucan and its designees, are entering into Amendment No. 3 (the "THIRD
AMENDMENT") to that certain Amended and Restated Recapitalization Agreement by
and between the parties thereto; and

      WHEREAS, in connection with the Third Amendment, the Company and Toucan
desire to amend the Convertible Preferred Stock Term Sheet as provided herein.

                                    AGREEMENT

      NOW, THEREFORE, for and in consideration of good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
Company and Toucan agree as follows:

      1. The paragraph of the Convertible Preferred Stock Term Sheet entitled
"Warrants:" is hereby amended and restated in its entirety as follows:

      "The Company shall issue $6.75 million in warrant coverage on the first
      $6.75 million Convertible Preferred Stock purchased for cash (the
      "Preferred Stock Warrants"). Preferred Stock Warrants shall not be issued
      upon conversion of notes, exercise of warrants, or other conversion or
      exercise. The number of warrants to be so issued shall be determined on
      the basis of $0.10 per share. If the total of $6.75 million is invested in
      Convertible Preferred Stock, the number of warrants issued shall be
      exercisable for 67.5 million shares of Convertible Preferred Stock. The
      exercise price of such Preferred Stock Warrants shall be the lesser of
      $0.10 per share (subject to adjustment for stock splits, stock dividends
      and the like) and 35% discount to the average closing price during the
      twenty trading days prior to the First Closing; provided, however, that in
      no event will the exercise price be less than $.04 per share (subject to
      adjustment for stock splits, stock dividends and the like). The exercise
      period shall commence upon issuance of the Preferred Stock Warrants, and
      shall continue for a period of seven (7) years after their respective
      issuance dates."

      2. The thirteenth bullet in the paragraph entitled "Conditions to Closing"
of the Convertible Preferred Stock term Sheet is hereby deleted in its entirety
and shall not be a

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                                                               EXECUTION VERSION

condition precedent to the obligation of any Investor to Purchase Convertible
Preferred Stock from the Company.

      3. Unless specifically modified or changed by the terms of this Amendment,
all terms and conditions of the Convertible Preferred Stock Term Sheet shall
remain in effect and shall apply fully as described and set forth in the
Convertible Preferred Stock Term Sheet.

      4. This Amendment may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

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                                       2.
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                                                               EXECUTION VERSION

      The Company and Toucan have executed this AMENDMENT TO AMENDED AND
RESTATED BINDING TERM SHEET as of the day and year first written above.

TOUCAN CAPITAL FUND II, L.P.                NORTHWEST BIOTHERAPEUTICS, INC.

By: /s/ Linda Powers                        By: /s/ Alton Boynton
    ____________________________                _____________________________
Name: Linda Powers                          Name: Alton L. Boynton
Title: Managing Director                    Title: President

                                       3.EXHIBIT 4.1

                                   RESOLUTIONS

      WHEREAS, the Company is indebted to Bruce E. Jameson for professional
services rendered and expenses incurred in connection with the business of the
Company.

      RESOLVED, that in payment for professional services rendered and expenses
incurred in connection with the business of the Company the Company hereby
grants to Bruce E. Jameson 490,345 shares of the Company's common stock, valued
at $.11 per share, to be registered in a registration statement on Form S-8 to
be filed with the Securities and Exchange Commission ("SEC") promptly after the
Company becomes current in all if its filing obligations under the Securities
Exchange Act of 1934 (the "Exchange Act").Ex. 10.1 - Form of Hudson United Bancorp 2002 Stock Option Plan Nonqualified
Stock Option Grant Agreement

	

Exhibit 10.1 

Name of Employee:  ________________________          
                        No. of Shares:  __________

Exercise Price:   ________

HUDSON UNITED BANCORP

NONQUALIFIED STOCK OPTION AGREEMENT 

        Hudson
United Bancorp, a New Jersey corporation (the “Company”), this ____ day of
__________, _____ (the “Option Date”) hereby grants to _______________ (the
“Employee”), an officer or employee of the Company or a subsidiary thereof,
pursuant to the Company’s 2002 Stock Option Plan (the “Plan”), an option
to purchase shares of the Common Stock, no par value, of the Company (“Common Stock”)
in the amount and on the terms and conditions hereinafter set forth.  

        Incorporation
by Reference of Plan.   The provisions of the Plan, a copy of which is
being furnished herewith to the Employee, are incorporated by reference herein and shall
govern as to all matters not expressly provided for in this Agreement. Terms not defined
herein have the meanings set forth in the Plan. In the event of any conflict between the
terms of this agreement and the Plan, the terms of the Plan shall govern.  

         Grant
of Option.   The Company hereby grants to the Employee the option (the
“Option”) to purchase all or any part of an aggregate of ___________ shares of
Common Stock (“Shares”) on the terms and conditions herein set forth. The Option
is a “Nonqualified” Option and is not intended to be an incentive option within
the meaning of Section 422 of the Code. 

         Purchase
Price.   The purchase price of the shares of Common Stock subject to the Option shall be
$_________ per share, subject to adjustment as provided in Section 10 below. 

Terms of Option.  (a)   Vesting.  
This Option shall not be exercisable until the dates shown below:

	Percentage
of Shares Which
May Be Purchased
Hereunder          	First Date On Which Such
Shares May be Purchased	Last Date On Which Such
Shares May be Purchased
	 		
		1 yr after Option Date	10 yrs after Option Date
		2 yrs after Option Date	10 yrs after Option Date
		3 yrs after Option Date	10 yrs after Option Date
		4 yrs after Option Date	10 yrs after Option Date
		5 yrs after Option Date	10 yrs after Option Date
	 		

	

        
        Notwithstanding
the foregoing vesting schedule, in the event of a Change in Control (as such term is
defined in the Plan), all options granted pursuant hereto shall become immediately
exercisable.  

        
        (b) Final
Termination.   Notwithstanding anything to the contrary set forth in Section 4(a), the
Option shall no longer be exercisable ten (10) years from the date hereof or such earlier
date as is prescribed in the Plan or in this Agreement.  

        Restrictions.                      This
Option is subject to all the terms and conditions set forth in the Plan
               including, but not limited to, the following:  

		       
    This Option
 is not  transferable  except  by will or by the laws of  descent  and
                      distribution, as provided in Section 6.3 of the Plan;  

		       
    This Option
may be exercised by the  Employee,  his estate or  beneficiary,  or his
                      legal  representative,  as the case may be, for a period of six (6)
months after the Employee dies                       or becomes  Disabled (as such term
is defined in the Plan),  or until the expiration of the stated
                      term of the Option, whichever period is shorter, as provided in
Section 6.2 of the Plan;  

		         
  This Option may be  exercised  by the  Employee  for a period of sixty (60) days
                      from the date of termination by reason of retirement,  voluntary
resignation, or dismissal without                       Cause (as such term is defined
 in the Plan) or until the  expiration  of the  stated  term of the
                      Option, whichever period is shorter, as provided in Section 6.2 of
the Plan;  

		           
This Option lapses upon the  termination of employment if the termination is by the
                      Company or by a subsidiary for Cause, as provided in Section 6.2 of
the Plan.  

	

        Exercise.  This
Option shall be exercised by notice to the Company, accompanied by full
               payment in cash or check (or Shares), as set forth in Section 7.2 of the
Plan. A                sample form to be used in exercising this Option is attached.  

2 

	

        Tax
Treatment Upon Exercise.   Generally, the Employee will recognize ordinary income upon
the exercise of this Option, the tax on which is subject to withholding and FICA. The
foregoing statement of tax consequences is intended only as a generalized statement of
current Federal tax law (as in existence on the date of this Agreement) and the Employee
should consult his or her tax consultant to determine the specific tax consequences of
his or her exercise of this Option at the time of such exercise. The Employee shall
deliver to the Company any Federal income tax withholding required by law in connection
herewith within 10 days after recognition of the income from exercise of this Option.  

        Securities
Law Restrictions.   The Company is under no obligation to file a registration statement
under the Securities Act of 1933 with respect to the Shares to be received upon exercise
of the Option. As provided by Article IX of the Plan, unless a registration statement
under the Act has been filed and remains effective with respect to the Shares, the
Company shall require that the offer and sale of such Shares be exempt from the
registration provisions of the Act. As a condition of such exemption, the Company shall
require a representation and undertaking, in form and substance satisfactory to counsel
for the Company, that the optionee is acquiring the Shares for his own account for
investment and not with a view to the distribution or resale thereof and shall otherwise
require such representations and impose such conditions as shall establish to the Company’s
satisfaction that the offer and sale of the Shares issuable upon the exercise of the
Option will not constitute a violation of the Act or any similar state act affecting the
offer and sale. If the Shares are issued in an exempt transaction, the Shares shall bear
the following restrictive legend:  

	  	
“These
shares have not been registered under the Securities Act of 1933. No transfer of the
shares may be affected without an opinion of counsel to the Company stating that the
transfer is exempt from registration under the Act and any applicable state securities
laws or that the transfer of the shares is covered by an effective registration statement
with respect to the shares.” 

	

        Restrictions
on Transfer.   This Option shall not be transferred (except by will or by the laws of
descent and distribution), assigned, pledged, or hypothecated and shall not be subject to
execution, attachment, or similar process. In the event the terms of this paragraph are
not complied with by the Employee, or if the Option is subject to execution, attachment,
or similar process, this Option shall immediately become null and void.  

        Anti-Dilution
Provisions.   If prior to expiration of the Option there shall occur any change in the
outstanding Common Stock of the Company by reason of any stock dividend, stock split,
combination or exchange of shares, merger, consolidation, recapitalization,
reorganization, liquidation, subscription rights offering, or the like, and as often as
the same shall occur, then the kind and number of shares subject to the Option, or the
purchase price per share of Common Stock, or both, shall be adjusted by the Compensation
Committee in such manner as it may deem equitable, the determination of which shall be
binding and conclusive. Failure of the Compensation Committee or Board to provide for any
such adjustment shall be conclusive evidence that no adjustment is required.  

3 

	

        Acceptance
of Provisions.   The execution of this Agreement by the Employee shall
constitute the Employee’s acceptance of and agreement to all of the terms and
conditions of the Plan and this Agreement.  

        Notices.                      All
notices and other communications required or permitted under the Plan and
               this Agreement shall be in writing and shall be given either by (i)
personal                delivery or regular mail, in each case against receipt, or (ii)
first class                registered or certified mail, return receipt requested. Any
such communication                shall be deemed to have been given (a) on the date of
receipt in the cases                referred to in clause (i) and (b) on the second day
after the date of mailing in                the cases referred to in clause (ii). All
such communications to the Company                shall be addressed to it, to the
attention of its Secretary or Treasurer, at its                then principal office and
to the Employee at his last address appearing on the                records of the
Company or, in each case, to such other person or address as may                be
designated by like notice hereunder.  

        Miscellaneous.                      This
Agreement and the Plan together contain a complete statement of all the
               arrangements between the parties with respect to their subject matter, and
this                Agreement cannot be changed except by a writing executed by both
parties. This                Agreement shall be governed by and construed in accordance
with the laws of the                State of New Jersey applicable to agreements made and
to be performed                exclusively in New Jersey. The headings in this Agreement
are solely for                convenience of reference and shall not affect its meaning
or interpretation.  

			HUDSON UNITED BANCORP

By:  
——————————————

——————————————

	

4 

	

FORM FOR EXERCISING
NONQUALIFIED STOCK OPTION 

_________________ , ____

Hudson United Bancorp

1000 MacArthur Boulevard
Mahwah, New Jersey 07430

Attn.:   Corporate Secretary 

Gentlemen: 

        
        I
am (check one) 

		                                           ___      an
employee of Hudson United Bancorp, Inc. or a subsidiary thereof (the “Company”) 

		                ___           a
former employee of the Company  

		                                           ___      the
designated beneficiary of an employee of the Company 

	

and, as such, I am entitled to
exercise the option (the “Option”) granted pursuant to the attached Hudson
United Bancorp Nonqualified Stock Option Agreement (the “Agreement”). 

        
        I wish
to exercise the Option to acquire _____ shares of Hudson United Bancorp Common Stock
(“Shares”) at the exercise price of ________, as set forth in the Agreement. My
total payment of _______ is enclosed. 

        
        (Check
one to indicate whether you are paying in:) 

___   Cash

___    Check made payable to Hudson United Bancorp

___     Other shares of Hudson United Bancorp Common Stock (to the extent not prohibited by the Agreement)

        
        Also
enclosed is a check for $_________, representing the withholding tax which I must pay to
you in connection with the exercise of the option. 

        
        If
the Shares I acquire hereby have not been registered for sale under the Securities Act of
1933, as amended (which the Company is under no obligation to do), I represent to you that
I am acquiring the Shares for investment purposes only and not with a view to distribution
and I authorize you to place an appropriate restrictive legend on the certificates
representing the Shares. 

	

        
        Please
make a notation on the Agreement to evidence my exercise of the Option as set forth and
return the Agreement (if any Options remain thereunder), along with a certificate
representing the shares, to me at the address below. 

			

  
——————————————

[Name of Employee]

——————————————

——————————————

——————————————

(PRINT ADDRESS)

	

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