Document:

<PAGE>

                    Form of Right Certificate

                 (Exhibit B to Rights agreement)

Certificate No. R-                                   _____ Rights

     NOT  EXERCISABLE AFTER FEBRUARY 1, 2009 OR  EARLIER  IF
     REDEMPTION OR EXCHANGE OCCURS.  THE RIGHTS ARE  SUBJECT
     TO  REDEMPTION AT $.01 PER RIGHT AND TO EXCHANGE ON THE
     TERMS SET FORTH IN THE RIGHTS AGREEMENT.

                        Right Certificate

                      CV Therapeutics, Inc.

     This   certifies  that  ___________________  or   registered
assigns,  is  the registered owner of the number  of  Rights  set
forth above, each of which entitles the owner thereof, subject to
the  terms,  provisions and conditions of the First  Amended  and
Restated Rights Agreement, dated as of July 19, 2000 (the "Rights
Agreement"),   between   CV  Therapeutics,   Inc.,   a   Delaware
corporation (the "Company"), and Wells Fargo Bank Minnesota, N.A.
(the  "Rights Agent"), to purchase from the Company at  any  time
after  the  Distribution Date (as such term  is  defined  in  the
Rights  Agreement)  and  prior to 5:00  P.M.,  Pacific  Time,  on
February 1, 2009 at the office of the Rights Agent designated for
such  purpose, or at the office of its successor as Rights Agent,
one  one-hundredth  of  a  fully  paid  non-assessable  share  of
Series  A Junior Participating Preferred Stock, par value $  .001
per share (the "Preferred Shares"), of the Company, at a purchase
price of $500.00 per one one-hundredth of a Preferred Share  (the
"Purchase Price"), upon presentation and surrender of this  Right
Certificate with the Form of Election to Purchase duly  executed.
The number of Rights evidenced by this Right Certificate (and the
number  of one one-hundredths of a Preferred Share which  may  be
purchased upon exercise hereof) set forth above, and the Purchase
Price  set forth above, are the number and Purchase Price  as  of
February 2, 1999, based on the Preferred Shares as constituted at
such date.

     From  and  after  the time any Person becomes  an  Acquiring
Person,  (as such terms are defined in the Rights Agreement),  if
the  Rights  evidenced by this Right Certificate are beneficially
owned by (i) an Acquiring Person or an Affiliate or Associate  of
any  such  Acquiring  Person (as such terms are  defined  in  the
Rights  Agreement),  (ii)  a transferee  of  any  such  Acquiring
Person, Associate or Affiliate who becomes a transferee after the
Acquiring   Person   becomes  such,  or   (iii)   under   certain
circumstances specified in the Rights Agreement, a transferee  of
any  such Acquiring Person, Associate or Affiliate who becomes  a
transferee  prior  to or concurrently with the  Acquiring  Person
becoming such, such Rights shall become null and void without any
further  action  and no holder hereof shall have any  right  with
respect to such Rights from and after the time any Person becomes
an Acquiring Person.

<PAGE>

     As  provided in the Rights Agreement, the Purchase Price and
the  number of one one-hundredths of a Preferred Share which  may
be  purchased upon the exercise of the Rights evidenced  by  this
Right Certificate are subject to modification and adjustment upon
the happening of certain events.

     This  Right  Certificate is subject to  all  of  the  terms,
provisions  and  conditions of the Rights Agreement,  as  amended
from  time  to  time, which terms, provisions and conditions  are
hereby  incorporated herein by reference and made a  part  hereof
and to which Rights Agreement reference is hereby made for a full
description  of  the rights, limitations of rights,  obligations,
duties  and immunities hereunder of the Rights Agent, the Company
and  the holders of the Right Certificates.  Copies of the Rights
Agreement are on file at the principal executive offices  of  the
Company and the above-mentioned offices of the Rights Agent.

     This   Right  Certificate,  with  or  without  other   Right
Certificates,  upon surrender at the office of the  Rights  Agent
designated  for such purpose, may be exchanged for another  Right
Certificate  or  Right  Certificates  of  like  tenor  and   date
evidencing  Rights  entitling  the  holder  to  purchase  a  like
aggregate  number of Preferred Shares as the Rights evidenced  by
the  Right  Certificate or Right Certificates  surrendered  shall
have entitled such holder to purchase.  If this Right Certificate
shall  be  exercised  in part, the holder shall  be  entitled  to
receive upon surrender hereof another Right Certificate or  Right
Certificates for the number of whole Rights not exercised.

     Subject  to  the  provisions of the  Rights  Agreement,  the
Rights  evidenced by this Certificate (i) may be redeemed by  the
Company  at a redemption price of $.01 per Right or (ii)  may  be
exchanged in whole or in part for shares of the Company's  Common
Stock,  par  value  $.001 per share, or, upon  circumstances  set
forth in the Rights Agreement, cash, property or other securities
of  the  Company,  including fractions of a  share  of  Preferred
Stock.

     No  fractional  Preferred Shares will  be  issued  upon  the
exercise  of  any  Right or Rights evidenced hereby  (other  than
fractions which are integral multiples of one one-hundredth of  a
Preferred  Share, which may, at the election of the  Company,  be
evidenced  by  depositary receipts) but in lieu  thereof  a  cash
payment will be made, as provided in the Rights Agreement.

     No  holder  of this Right Certificate shall be  entitled  to
vote or receive dividends or be deemed for any purpose the holder
of the Preferred Shares or of any other securities of the Company
which  may  at any time be issuable on the exercise  hereof,  nor
shall  anything contained in the Rights Agreement  or  herein  be
construed to confer upon the holder hereof, as such, any  of  the
rights  of a stockholder of the Company or any right to vote  for
the  election  of  directors  or upon  any  matter  submitted  to
stockholders  at  any  meeting thereof, or to  give  or  withhold
consent to any corporate action, or to receive notice of meetings
or  other  actions affecting stockholders (except as provided  in
the  Rights  Agreement), or to receive dividends or  subscription
rights, or otherwise, until the Right or Rights evidenced by this
Right  Certificate shall have been exercised as provided  in  the
Rights Agreement.

     This Right Certificate shall not be valid or obligatory  for
any  purpose until it shall have been countersigned by the Rights
Agent.

<PAGE>

     Witness  the  facsimile signature of the proper officers  of
the Company and its corporate seal.  Dated as of July 19, 2000.

Attest:                            CV Therapeutics, Inc.

By:_______________________           By:__________________________
     Alan C. Mendelson                   Louis G. Lange
     Secretary                           Chairman of the Board and
                                         Chief Executive Officer

Countersigned:

Wells Fargo Bank Minnesota, N.A.
  as Rights Agent

By:_______________________

Print Name:  Beverly Robinson

Title:  Account Manager

<PAGE>

            Form of Reverse Side of Right Certificate

                       FORM OF ASSIGNMENT

        (To be executed by the registered holder if such
       holder desires to transfer the Right Certificate.)

     FOR  VALUE  RECEIVED  ______________________________________
hereby sells, assigns and transfers unto

          (Please print name and address of transferee)

_________________________________________________________________
____  this Right Certificate, together with all right, title  and
interest  therein,  and  does hereby irrevocably  constitute  and
appoint ________________________ Attorney, to transfer the within
Right Certificate on the books of the within-named Company,  with
full power of substitution.

Dated:  ____________________

                                   ______________________________
                                   Signature

     Form of Reverse Side of Right Certificate -- continued

<PAGE>

Signature Guaranteed:

     Signatures  must  be  guaranteed by an  "eligible  guarantor
institution"  as  defined in Rule 17Ad-15 promulgated  under  the
Securities Exchange Act of 1934, as amended.

---------------------------------------------------------------

     The   undersigned  hereby  certifies  that  (1)  the  Rights
evidenced by this Right Certificate are not being sold,  assigned
or  transferred  by or on behalf of a Person who  is  or  was  an
Acquiring  Person, an Interested Stockholder or an  Affiliate  or
Associate  thereof  (as  such terms are  defined  in  the  Rights
Agreement);  and  (2) after due inquiry and to the  best  of  the
knowledge of the undersigned, the undersigned did not acquire the
Rights evidenced by this Right Certificate from any Person who is
or  was  an  Acquiring Person, an Interested Stockholder,  or  an
Affiliate or Associate thereof.

                                   ______________________________
                                   Signature

<PAGE>

                  FORM OF ELECTION TO PURCHASE

          (To be executed if holder desires to exercise
          Rights represented by the Right Certificate.)

To Wells Fargo Bank Minnesota, N.A.;

     The   undersigned  hereby  irrevocably  elects  to  exercise
___________________________  Rights  represented  by  this  Right
Certificate  to purchase the Preferred Shares issuable  upon  the
exercise  of such Rights and requests that certificates for  such
Preferred Shares be issued in the name of:

Please insert social security
or other identifying number: ______________

______________________________________________________________
               (Please print name and address)

______________________________________________________________

If such number of Rights shall not be all the Rights evidenced by
this  Right Certificate, a new Right Certificate for the  balance
remaining of such Rights shall be registered in the name  of  and
delivered to:

Please insert social security
or other identifying number: ______________

______________________________________________________________
               (Please print name and address)

______________________________________________________________

Dated:  _________________

                                   ______________________________
                                   Signature

     Form of Reverse Side of Right Certificate -- continued

<PAGE>

Signature Guaranteed:

     Signatures  must  be  guaranteed by an  "eligible  guarantor
institution"  as  defined in Rule 17Ad-15 promulgated  under  the
Securities Exchange Act of 1934, as amended.

---------------------------------------------------------------

     The   undersigned  hereby  certifies  that  (1)  the  Rights
evidenced by this Right Certificate are not beneficially owned by
nor are they being exercised on behalf of an Acquiring Person, an
Interested  Stockholder or an Affiliate or Associate thereof  (as
such  terms are defined in the Rights Agreement); and  (2)  after
due  inquiry and to the best of the knowledge of the undersigned,
the  undersigned  did not acquire the Rights  evidenced  by  this
Right  Certificate  from any Person who is or  was  an  Acquiring
Person,  an Interested Stockholder, or an Affiliate or  Associate
thereof.

                                   ______________________________
                                   Signature

---------------------------------------------------------------

                             NOTICE

     The  signature in the Form of Assignment or Form of Election
to  Purchase,  as the case may be, must conform to  the  name  as
written  upon  the  face  of  this  Right  Certificate  in  every
particular,  without  alteration or  enlargement  or  any  change
whatsoever.

     In  the event the certification set forth above in the  Form
of  Assignment or the Form of Election to Purchase, as  the  case
may  be, is not completed, the Company and the Rights Agent  will
deem  the beneficial owner of the Rights evidenced by this  Right
Certificate  to  be  an  Acquiring  Person  or  an  Affiliate  or
Associate thereof (as defined in the Rights Agreement)  and  such
Assignment or Election to Purchase will not be honored.<PAGE>

                      CV THERAPEUTICS, INC.

                  Summary of Rights to Purchase
                        Preferred Shares

     On   February  2,  1999,  the  Board  of  Directors  of   CV
Therapeutics,  Inc. (the "Company") declared a  dividend  of  one
preferred  share purchase right (a "Right") for each  outstanding
share  of  common stock, par value $.001 per share  (the  "Common
Shares"),  of  the  Company.  The dividend was  effective  as  of
February  23,  1999  (the  "Record Date")  with  respect  to  the
stockholders  of  record on that date.   On July  19,  2000,  the
Rights  were amended, and this Summary sets forth the  Rights  as
amended.

     The  Rights  will  attach to new Common Shares issued  after
the  Record Date.  Each Right entitles the registered  holder  to
purchase  from  the  Company  one one-hundredth  of  a  share  of
Series  A  Junior Participating Preferred Stock, par value  $.001
per share (the "Preferred Shares"), of the Company at a price  of
$500.00 per one one-hundredth of a Preferred Share (the "Purchase
Price"), subject to adjustment.  Each Preferred Share is designed
to  be  the  economic  equivalent  of  100  Common  Shares.   The
description  and terms of the Rights are set forth in  the  First
Amended and Restated Rights Agreement, dated as of July 19,  2000
(the  "Rights  Agreement"), between the Company and  Wells  Fargo
Bank Minnesota, N.A. (the "Rights Agent").

Detachment and Transfer of Rights

     Initially,  the  Rights  will  be  evidenced  by  the  stock
certificates representing Common Shares then outstanding, and  no
separate  Right  Certificates will  be  distributed.   Until  the
earlier  to occur of (i) a public announcement that a  person  or
group  of  affiliated  or  associated  persons,  has  become   an
"Acquiring  Person"  (as  such term  is  defined  in  the  Rights
Agreement)  or (ii) 10 business days (or such later date  as  the
Board   may   determine)  following  the  commencement   of,   or
announcement of an intention to make, a tender offer or  exchange
offer  which  would  result  in the beneficial  ownership  by  an
Acquiring Person of 15% or more of the outstanding Common  Shares
(the earlier of such dates being called the "Distribution Date"),
the  Rights will be evidenced, with respect to any of the  Common
Share  certificates outstanding as of the Record  Date,  by  such
Common Share certificate.  In general, an "Acquiring Person" is a
person, the affiliates or associates of such person, or a  group,
which  has  acquired beneficial ownership of 15% or more  of  the
outstanding Common Shares.

     The  Rights  Agreement provides that, until the Distribution
Date  (or  earlier redemption or expiration of the  Rights),  the
Rights will be transferable with and only with the Common Shares.
Until  the Distribution Date (or earlier redemption or expiration
of  the  Rights), new Common Share certificates issued after  the
Record  Date upon transfer or new issuance of Common Shares

<PAGE>

will contain a notation incorporating  the  Rights Agreement   by
reference.  Until the Distribution Date (or earlier redemption or
expiration  of  the  Rights) the surrender  or  transfer  of  any
certificates for Common Shares outstanding as of the Record Date,
even  without such notation or a copy of this Summary  of  Rights
being attached thereto, will also constitute the transfer of  the
Rights  associated  with the Common Shares  represented  by  such
certificate.   As soon as practicable following the  Distribution
Date,   separate  certificates  evidencing  the  Rights   ("Right
Certificates") will be mailed to holders of record of the  Common
Shares  as of the close of business on the Distribution Date  and
such separate Right Certificates alone will evidence the Rights.

Exercisability of Rights

     The  Rights are not exercisable until the Distribution Date.
The Rights will expire on February 1, 2009 (the "Final Expiration
Date"),  unless the Final Expiration Date is extended  or  unless
the  Rights are earlier redeemed or exchanged by the Company,  in
each  case  as described below.  Until a Right is exercised,  the
holder thereof, as such, will have no rights as a stockholder  of
the Company, including, without limitation, the right to vote  or
to receive dividends.

     The  Purchase  Price  payable, and the number  of  Preferred
Shares or other securities or property issuable or payable,  upon
exercise  of  the Rights are subject to adjustment from  time  to
time  to prevent dilution.  The number of outstanding Rights  and
the  number  of one one-hundredths of a Preferred Share  issuable
upon exercise of each Right are also subject to adjustment in the
event  of  a stock split of the Common Shares or a stock dividend
on  the  Common Shares payable in Common Shares, or subdivisions,
consolidations or combinations of the Common Shares occurring, in
any  such  case,  prior to the Distribution Date.   With  certain
exceptions, no adjustment in the Purchase Price will be  required
until cumulative adjustments require an adjustment of at least 1%
in  such Purchase Price.  No fractional Preferred Shares will  be
issued (other than fractions which are integral multiples of  one
one-hundredth of a Preferred Share, which may, at the election of
the  Company, be evidenced by depositary receipts)  and  in  lieu
thereof,  an adjustment in cash will be made based on the  market
price  of  the Preferred Shares on the last trading day prior  to
the date of exercise.

Terms of Preferred Shares

     Preferred  Shares purchasable upon exercise  of  the  Rights
will not be redeemable.  Each Preferred Share will be entitled to
a minimum preferential quarterly dividend payment of $l per share
but  will  be entitled to an aggregate dividend of 100 times  the
dividend declared per Common Share.  In the event of liquidation,
the holders of the Preferred Shares will be entitled to a minimum
preferential liquidation payment of $100 per share  but  will  be
entitled  to  an aggregate payment of 100 times the payment  made
per  Common  Share.  Each Preferred Share will  have  100  votes,
voting together with the Common Shares.  Finally, in the event of
any  merger,  consolidation or other transaction in which  Common
Shares  are  exchanged, each Preferred Share will be entitled  to
receive  100  times the amount received per Common Share.   These
rights  are  protected  by  customary  anti-dilution  provisions.
Because   of  the  nature  of  the

<PAGE>

Preferred  Shares'  dividend,
liquidation and voting rights, the value of the one one-hundredth
interest in a Preferred Share purchasable upon exercise  of  each
Right  should  approximate the value of one  Common  Share.   The
Preferred  Shares would rank junior to any other  series  of  the
Company's preferred stock.

Trigger of Flip-In and Flip-Over Rights

     In  the  event  that any person or group  of  affiliated  or
associated persons becomes an Acquiring Person, proper  provision
shall  be made so that each holder of a Right, other than  Rights
beneficially  owned by the Acquiring Person or any  affiliate  or
associate   thereof  (which  will  thereafter  be   void),   will
thereafter  have the right to receive upon exercise, that  number
of  Common Shares having a market value of two times the exercise
price  of  the Right.  This right will commence on  the  date  of
public  announcement that a person has become an Acquiring Person
(or  the  effective date of a registration statement relating  to
distribution of the rights, if later) and terminate 60 days later
(subject  to  adjustment in the event exercise of the  rights  is
enjoined).

     In  the  event that the Company is acquired in a  merger  or
other  business  combination transaction or 50% or  more  of  its
consolidated  assets or earning power are sold  to  an  Acquiring
Person, its affiliates or associates or certain other persons  in
which  such  persons have an interest, proper provision  will  be
made so that each such holder of a Right will thereafter have the
right  to receive, upon the exercise thereof at the then  current
exercise  price  of the Right, that number of  shares  of  common
stock  of  the  acquiring  company which  at  the  time  of  such
transaction  will have a market value of two times  the  exercise
price of the Right.

Redemption and Exchange of Rights

     At  any  time  prior to the earliest of  (i)  the  close  of
business  on  the  day  of the first public announcement  that  a
person  has  become  an  Acquiring  Person,  or  (ii)  the  Final
Expiration Date, the Board of Directors of the Company may redeem
the  Rights  in whole, but not in part, at a price  of  $.01  per
Right  (the  "Redemption Price").  In general, the redemption  of
the  Rights may be made effective at such time on such basis with
such  conditions as the Board of Directors in its sole discretion
may  establish.  Immediately upon any redemption of  the  Rights,
the  right  to  exercise the Rights will terminate and  the  only
right  of the holders of Rights will be to receive the Redemption
Price.

     At any time after any Person becomes an Acquiring Person and
prior  to the acquisition by such person or group of 50% or  more
of  the outstanding Common Shares, the Board of Directors of  the
Company may exchange the Rights (other than Rights owned by  such
person  or  group which will have become void), in  whole  or  in
part,  at  an  exchange  ratio of one  Common  Share,  or,  under
circumstances  set forth in the Rights Agreement, cash,  property
or  other  securities of the Company, including  fractions  of  a
Preferred  Share  (or  of a share of a class  or  series  of  the
Company's preferred stock having equivalent designations and  the
powers,   preferences   and  rights,  and   the   qualifications,
limitations  and restrictions), per Right (with  value  equal  to
such Common Shares).

<PAGE>

Amendment of Rights

     The  terms  of  the Rights generally may be amended  by  the
Board  of  Directors of the Company without the  consent  of  the
holders  of the Rights, except that from and after such  time  as
the Rights are distributed no such amendment may adversely affect
the  interests  of  the  holders of  the  Rights  (excluding  the
interest of any Acquiring Person).

Additional Information

     A  copy  of  the  Rights Agreement has been filed  with  the
Securities and Exchange Commission as an Exhibit to the Company's
Quarterly  Report  on Form 10-Q for the quarter  ended  June  30,
2000.   A  copy  of  the Rights Agreement is available  from  the
Company by writing to:  CV Therapeutics, Inc., 3172 Porter Drive,
Palo  Alto,  California 94304, Attn: Daniel K. Spiegelman.   This
summary  description of the Rights is not intended to be complete
and  is  qualified  in its entirety by reference  to  the  Rights
Agreement, which is hereby incorporated herein by reference.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00013-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00013-of-00352.parquet"}]]