Document:

Prepared by R.R. Donnelley Financial -- Assignment and Assumption Agreement

  
 EXHIBIT 10.25 
  
 ASSIGNMENT AND ASSUMPTION AGREEMENT 
  
 THIS ASSIGNMENT AND ASSUMPTION AGREEMENT
(“Agreement”) is entered into as of February 25, 2002 (the “Effective Date”), by and between THE IMMUNE RESPONSE CORPORATION, a Delaware corporation (“IRC”), having a principle place of business at 5935 Darwin Court,
Carlsbad, California 92008 and GENSTAR THERAPEUTICS CORPORATION, a Delaware corporation (“GenStar”), having a principle place of business at 10865 Altman Row, San Diego, California 92121, with respect to the following facts: 

 
 RECITALS 
  
 WHEREAS, IRC and the
Regents of the University of California (the “Regents”) entered into that certain License Agreement effective March 21, 1996 (the “Regents License Agreement”), pursuant to which the Regents granted to IRC an exclusive license
under certain patent rights on the terms and subject to the conditions of the Regents License Agreement; 
  
 WHEREAS, IRC and
GenStar entered into that certain License Agreement dated March 5, 1997 (as amended by that certain Amendment To License Agreement effective January 29, 1999, the “GenStar License Agreement”), pursuant to which IRC granted to GenStar an
exclusive license under such patent rights on the terms and subject to the conditions of the GenStar License Agreement; 
  
 WHEREAS, IRC and GenStar desire to terminate the GenStar License Agreement, and to assign to GenStar all of IRC’s rights and obligations under the Regents License Agreement, on the terms and conditions set forth herein; 

 
 NOW, THEREFORE, the parties agree as follows: 
  
 1.    Definitions.    All capitalized terms used, but not defined, herein shall have the respective meanings set forth in the Regents License Agreement. 

 
 2.    Condition Precedent.    The effectiveness of this Agreement shall be conditioned upon
the due execution and delivery of the Consent of Substitution of Party among the Regents, IRC and GenStar in the form attached hereto as Exhibit A (the “Consent”). 
  
 3.    Assignment and Assumption.    IRC hereby assigns and transfers to GenStar, and GenStar hereby accepts from IRC, all of IRC’s
rights and obligations under the Regents License Agreement. GenStar agrees to be bound by and to perform all obligations of IRC accruing on or after the Effective Date under the Regents License Agreement and IRC agrees to perform all obligations of
IRC accruing prior to the Effective Date. 
  
 4.    Indemnity.    GenStar shall
indemnify and hold IRC harmless from and against any and all losses, liabilities, damages and expenses (including reasonable attorneys’ fees and costs) incurred or suffered by IRC arising from the Regents License Agreement after the Effective
Date. IRC shall indemnify and hold GenStar harmless from and against any and all losses, liabilities, damages and expenses (including reasonable attorneys’ fees and costs) incurred or suffered by GenStar arising from the Regents License
Agreement (but not the GenStar License 
 

  
 Agreement) prior to the Effective Date. Nothing in the Consent shall affect IRC’s indemnification obligations under
this Section. 
  
 5.    Consideration.    In consideration for the assignment and
transfer by IRC to GenStar hereunder, GenStar shall pay IRC as follows: 
  
 5.1 GenStar shall pay to IRC an
acquisition fee of one hundred thousand dollars ($100,000), payable on the Effective Date. 
  
 5.2 Within thirty
(30) calendar days after GenStar’s receipt of the required marketing and pricing approval from the FDA (or from the governing health authority of any other country) to sell the first Licensed Product or Licensed Method for use in the Field,
GenStar shall pay to IRC a milestone fee of two hundred thousand dollars ($200,000). 
  
 5.3 All payments by
GenStar to IRC pursuant to this Agreement shall be paid in United States dollars and shall be paid by wire transfer in immediately available funds into such accounts as IRC may direct in writing to GenStar. Late payments shall bear interest at a
rate equal to the lesser of one and one-half percent (11⁄2%) per month or the maximum amount permitted by applicable law. 
  
 6.    Representations and Warranties.    Each party hereby represents and warrants to the other party as follows: 
  
 6.1 Corporate Existence.    Such party is a corporation duly organized, validly existing and in good standing under the laws of the state in
which it is incorporated. 
  
 6.2 Authorization and Enforcement of
Obligations.    Such party (a) has the corporate power and authority and the legal right to enter into this Agreement and to perform its obligations hereunder, and (b) has taken all necessary corporate action on its part to
authorize the execution and delivery of this Agreement and the performance of its obligations hereunder. This Agreement has been duly executed and delivered on behalf of such party, and constitutes a legal, valid, binding obligation, enforceable
against such party in accordance with its terms. 
  
 6.3 No Consents.    In addition
to the Consent of Substitution of Party among the Regents, IRC and GenStar described in Section 2 above, all necessary consents, approvals and authorizations of all governmental authorities and other Persons required to be obtained by such party in
connection with this Agreement have been obtained. 
  
 6.4 No Conflict.    The
execution and delivery of this Agreement and the performance of such party’s obligations hereunder (a) do not conflict with or violate any requirement of applicable laws or regulations, and (b) do not conflict with, or constitute a default
under, any contractual obligation of it. 
  
 7.    Representations and Warranties of
IRC.    IRC hereby represents and warrants to GenStar as follows: 
  
 7.1 Full Force
and Effect.    The Regents License Agreement is in full force and effect as of the Effective Date and IRC has not received any notice of termination thereof. 
 

 2 

  
 7.2 No Obligations or Breach. To its knowledge, as of the Effective
Date, there are no obligations of IRC under the Regents License Agreement which have accrued and have not been met, and IRC has not received any notice of breach of the Regents License Agreement. 
  

8.    Termination of the GenStar License Agreement.    Subject to the effectiveness of this Agreement, the GenStar License Agreement
shall be terminated as of the Effective Date and of no further force and effect. 
  
 9.    Further
Assurances.    Each party shall perform any further acts and execute and deliver any further documents that may be reasonably necessary to carry out the provisions of this Agreement. 
  
 10.    General.    This Agreement is the entire agreement between the parties concerning the subject
matter hereof. All prior agreements, promises or negotiations, whether written or oral, including without limitation the GenStar License Agreement, are superseded by this Agreement. This Agreement is governed by California law, without regard to
conflict of laws principles. This Agreement may be executed in any number of counterparts, each of which shall be deemed to be an original and all of which together shall be deemed to be one and the same instrument. 
  
 IN WITNESS WHEREOF, the undersigned have duly executed and delivered this Agreement effective as of the Effective Date. 
  

	 	TH
	E IMMUNE RESPONSE CORPORATION 
 

  

	 	By
	                                      
         
 

  

	 	Pri
	nted Name:
                                    

  

	 	Tit
	le                                      
      
 

  

	 	GE
	NSTAR THERAPEUTICS CORPORATION 
 

  

	 	By
	                                      
         
 

	 	    
	    Lee McCracken, President and Chief 
 

	 	    
	    Business Officer 
 

 

 3 

  
 EXHIBIT A 
  
 CONSENT OF SUBSTITUTION OF PARTY 
 

 4<PAGE>

                                                                   EXHIBIT 10.38

                            FIRST AMENDMENT TO LEASE
                            ------------------------

               THIS FIRST AMENDMENT TO LEASE (this "Amendment") is made as of
May 4, 2000, between GAL-BRISBANE, L.P., a California limited partnership
("Landlord") and SNOWBALL.COM, a Delaware corporation ("Tenant"), on the basis
of the following facts, understandings and intentions:

         A.    Landlord and Tenant previously entered into that certain Lease
dated as of November 29, 1999 ("Lease") with respect to three (3) office
buildings under construction commonly known as 3280, 3260 and 3240 Bayshore
Boulevard, Brisbane, California 94005. The capitalized terms used in this
Amendment and not otherwise defined herein shall have the same meaning given to
such terms in the Lease.

         B.    Tenant has submitted to Landlord Preliminary Plans for Building
A, Building B and Building C ("Submitted Plans") pursuant to the Work Letter. A
copy of the Submitted Plans is attached hereto as Exhibit A.
                                                  ---------

         C.    The Submitted Plans contain modifications to the Building Shells
for each Building, including the closure of lobby stairwell penetrations in each
Building and the creation of new core area penetrations in Building B. The
Submitted Plans for Building B also contain a non-standard, unstacked bathroom
on the second floor.

         D.    Landlord and Tenant agree that Tenant may construct the Tenant
Improvements shown on the Submitted Plans on the terms and conditions set forth
in this Amendment.

         NOW, THEREFORE, IN CONSIDERATION of the mutual covenants and promises
of the parties, the receipt and adequacy of which are hereby acknowledged, the
parties hereto agree as follows:

         1.    Approval of Submitted Plans. Subject to the terms and conditions
               ---------------------------
of this Amendment, Landlord hereby approves the Submitted Plans pursuant to
Paragraph F(i) of the Work Letter.

         2.    Demolition and Restoration. Upon the expiration or earlier
               --------------------------
termination of the Lease, Tenant (a) shall remove the improvements designated to
be removed on the demolition and plans for the Buildings attached hereto as
Exhibit B ("Demolition & Restoration Plans"), (b) shall restore and/or provide
---------
the improvements designated to be restored or provided on the Demolition and
Restoration Plans, and (c) shall not remove the improvements designated to
                                 ---
remain on the Demolition and Restoration Plans. Tenant shall repair any damage
caused by such work. Tenant's obligations under this Paragraph 2 are in addition
to and are not in lieu of any other requirements of the Lease governing the
return of the Premises upon the expiration or earlier termination of the Lease,
including but not limited to Paragraph 16 of the Lease.

         3.    Final Plans. The Submitted Plans constitute preliminary Plans,
               -----------
and do not show all of the Tenant Improvements Tenant intends to construct in
the Premises. Nothing set forth in this Amendment is intended to limit
Landlord's right upon receipt of Final Plans for the Tenant

<PAGE>

Improvements to review and approve the Final Plans, or to designate for removal
upon the expiration or earlier termination of the Lease additional Non-General
Purpose Office Improvements pursuant to Paragraph F(ii) of the Work Letter.

         4.    Elevators.
               ---------

               4.1.   Installation by Tenant. Tenant shall install one elevator
                      ----------------------
in each Building as part of Tenant's Work under the Work Letter. The elevators
are presently on order from Thyssen Dover and have been approved by Landlord and
Tenant. Tenant shall be solely responsible for the cost to purchase, deliver,
and install the elevators in the Premises in the locations shown in the
Submitted Plans and in accordance with the requirements of the Work Letter,
provided that Landlord shall contribute up to a maximum of Two Hundred
Ninety-Eight Thousand Dollars ($298,000) ("Elevator Allowance") towards such
costs and no others.

               4.2    Payment of Elevator Allowance. Landlord shall make monthly
                      -----------------------------
disbursements to Tenant from the Elevator Allowance; provided that with respect
to each disbursement (A) Landlord shall have first received (i) an AIA G702/G703
Application and Certification for Payment with respect to the work completed and
for which Tenant is seeking reimbursement, executed by Tenant's Architect and
Tenant's Contractor, and (ii) an Unconditional Waiver and Release Upon Progress
Payment with respect to the amount requested, in the form prescribed by Section
3262 of the California Civil Code, (B) the work for which a disbursement is
requested shall have been substantially completed in accordance with the plans
and specifications approved by Landlord, and (C) Tenant shall not be in default
of any material terms of the Lease. Each disbursement shall be subject to a ten
percent (10%) retention, which retention shall not be disbursed until the
following items, in addition to satisfaction of the requirements listed above
(other than (A)(ii)), have been received by Landlord: (a) a final operating
permit for each elevator issued by the appropriate agency or department of the
State of California, and (b) an Unconditional Waiver and Release Upon Final
Payment in the form prescribed by Section 3262 of the California Civil Code.

               4.3    Elevator Use. Prior to the time that Tenant's Work is
                      ------------
completed, Tenant shall not use, and Tenant shall prevent its contractors,
consultants and other representatives from using, the elevators except as
necessary to install and test the elevators. Notwithstanding the foregoing,
Tenant may use the elevators to transport Tenant's office furniture within each
Building; provided Tenant shall take reasonable and customary precautions to
protect the elevators, including but not limited to the use of wall and ceiling
pads and floor protection. Any damage to the elevators caused by Tenant or
Tenant's contractors, agents, and consultants shall be promptly repaired by
Tenant at Tenant's sole cost.

         5.    Entire Agreement. This Amendment represents the entire
               ----------------
understanding between Landlord and Tenant concerning the subject matter hereof,
and there are no understandings or agreements between them relating to the Lease
or the Premises not set forth in writing and signed by the parties hereto. No
party hereto has relied upon any representation, warranty or understanding not
set forth herein, either oral or written, as an inducement to enter into this
Amendment.

                                       2

<PAGE>

         6.   Continuing Obligations. Except as expressly set forth to the
              ----------------------
contrary in this Amendment, the Lease, including but not limited to the Work
Letter, remains unmodified and in full force and effect. To the extent of any
conflict between the terms of this Amendment and the terms of the Lease, the
terms of this Amendment shall control.

         IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the day and year first above written.

"Landlord"

GAL-BRISBANE, L.P.,
a California limited partnership

By: Brisbane Tech LLC,
    a Delaware limited liability company,
    its General Partner

    By: Stuhlmuller Real Estate, LLC,
        a Delaware limited liability company

        By: /s/ ROGER C. STUHLMULLER
            --------------------------------
            Roger C. Stuhlmuller
            Manager

"Tenant"

SNOWBALL.COM, INC.,
a Delaware corporation

By: /s/ JAMES R. TOLONEN
    ----------------------------------------
Name: James R. Tolonen
     ---------------------------------------
Its:  COO/CFO
     ---------------------------------------

By:_________________________________________
Name:_______________________________________
Its:________________________________________

                                       3

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