Document:

Employment Agreement between Registrant and Bruce J. Seeley

 Exhibit 10.10 
 NANOSTRING TECHNOLOGIES, INC. 
 BRUCE SEELEY EMPLOYMENT AGREEMENT

 This Agreement is entered into as of May 18, 2012 (this “Agreement”) by and between
NanoString Technologies, Inc., a Delaware corporation (the “Company”), and Bruce Seeley (“Executive”). 
 1. Position. 
 (a) Title. Executive will serve as the Sr. Vice
President & General Manager, Diagnostics of the Company. Executive will render such business and professional services in the performance of his duties, consistent with Executive’s position within the Company, as shall reasonably be
assigned to him by the Company’s Chief Executive Officer (“CEO”) and/or Board of Directors (the “Board”). The period of Executive’s employment under this Agreement is referred to herein as the
“Employment Term” and shall commence on May 21, 2012. 
 (b) Obligations. Executive agrees to the
best of his ability and experience that he will at all times loyally and conscientiously perform all of the duties and obligations required of and from him pursuant to the express and implicit terms hereof, and to the reasonable satisfaction of the
Company. During the Employment Term, Executive further agrees that he will not engage in any other employment, occupation, consulting, or other business activity directly related to the business in which the Company is now involved or becomes
involved during the Employment Term, nor will he engage in any other activities that conflict with his obligations to the Company. Nothing in this Agreement will prevent Executive from accepting speaking or presentation engagements in exchange for
honoraria or from serving on boards of charitable organizations, or from owning no more than one percent (1%) of the outstanding equity securities of a corporation whose stock is listed on a national stock exchange. Subject to the discretion
and approval of the Company’s Board of Directors confirmed in writing by the CEO, Executive shall be free to serve on the board of directors of one corporation. 
 2. At-Will Employment. The parties agree that, subject to the terms of this Agreement, Executive’s employment with the Company is “at-will” and may be terminated at any time with or
without cause or notice. Executive understands and agrees that neither his job performance nor promotions, commendations, bonuses or the like from the Company give rise to or in any way serve as the basis for modification, amendment, or extension,
by implication or otherwise, of his employment with the Company. The at-will nature of Executive’s employment cannot be modified or amended except by a written agreement signed by Executive and the Company’s CEO. 

3. Compensation. 
 (a) Base Salary. During the Employment Term, the Company will pay Executive as compensation for his services a base salary at the annualized rate of three hundred thousand dollars ($300,000) (the
“Base Salary”). Executive’s Base Salary shall increase to the annualized 

  
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rate of at least three hundred twenty thousand dollars ($320,000) upon the earlier to occur of (i) the one (1) year anniversary of the beginning of the Employment Term, or (ii) the
closing of the Company’s sale of its common stock in a firm commitment underwritten public offering pursuant to a registration statement under the Securities Act of 1933, as amended. The Base Salary will be paid periodically in accordance with
the Company’s normal payroll practices and be subject to the usual, required withholdings, and change at the Company’s discretion, including annual review by the Board for any appropriate adjustment. 

(b) Signing Bonus. The Company will pay Executive a signing bonus of twenty-eight thousand dollars ($28,000) (the “Signing
Bonus”). The Signing Bonus will be paid with the first regular payroll to occur thirty (30) days after the beginning of the Employment Term and will be subject to the usual, required withholdings. If Executive terminates his employment
with the Company for any reason other than Good Reason (as defined below) within the first twelve (12) months of the Employment Term, then Executive must refund the Company for the Signing Bonus (without credit for withholdings or pro-ration
for partial service, etc.), and Executive hereby expressly consents to have such amount withheld from his final paycheck if he is obligated to refund the Signing Bonus under this paragraph. Executive shall have no obligation to refund the Company
for the Signing Bonus if he terminates his employment with the Company after the one (1) year anniversary of the Employment Term, or if he terminates his employment with the Company at any time for Good Reason (as defined below). 

(c) Bonus. Executive shall be eligible to be considered for an annual, performance-based, cash bonus of up to 40% of
Executive’s Base Salary for each calendar year, which bonus shall be awarded in the sole discretion of the Compensation Committee of the Board of Directors based on a recommendation from the CEO, which shall be based on Executive’s
performance in the prior calendar year against metrics established for such year by the Company. Any bonus awarded shall be paid by no later than March 15 following the calendar year to which the bonus corresponds. If Executive is terminated by
or leaves the Company prior to the end of a given calendar year, then the Company shall have no obligation to pay a bonus to Executive for such year. For the year ending December 31, 2012, Executive’s bonus will be prorated based upon his
start date. 
 (d) Equity Grant. In connection with the commencement of Executive’s employment, the Company will
recommend that the Board of Directors grant Executive an option to purchase two million six hundred and fifty five thousand (2,655,000) shares of common stock of the Company (the “Stock Option”), with an exercise price equal to
the fair market value on the date or grant. The Stock Option will vest at the rate of 25% of the shares on the twelve (12) month anniversary of Executive’s Vesting Commencement Date (as defined in his Stock Option Agreement, which date
will be the first day of the Employment Term) and the remaining Stock Option shares will vest monthly thereafter at the rate of 1/48 of the total number of the Option Shares per month. Vesting will, of course, depend on Executive’s continued
employment with the Company. The Stock Option will be subject to the terms of the Company’s 

  
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2004 Stock Option Plan (the “Plan”). In the event that there is a Change in Control (as such term is defined in the Plan), and the Executive is terminated from employment without
Cause (as defined below) or resigns for a Good Reason (as defined below) on or within twelve (12) months after the effective date of such Change in Control, then one hundred percent (100%) of the unvested portion of the Stock Option shall
vest and become exercisable at the time of Executive’s termination from Employment. The Stock Option will be an incentive stock option to the maximum extent permitted by law and will be subject to the terms of the Plan and a stock option
agreement between Executive and the Company, including but not limited to a “lock up” provision and a right of first refusal in favor of the Company. 
 4. Employee Benefits. During the Employment Term, Executive will be entitled to participate in the employee benefit plans currently and hereafter maintained by the Company of general applicability
to other senior executives of the Company, including, without limitation, the Company’s medical plans. The Company reserves the right to cancel or change the benefit plans and programs it offers to its employees at any time. Executive shall
also be entitled to take paid vacation consistent with the Company’s vacation policy approved by the Board. 
 5.
Severance benefits. 
 (a) Involuntary Termination. If Executive’s employment with the Company terminates as
a result of an Involuntary Termination (as defined below), and Executive signs and does not revoke a standard release of claims with the Company within sixty (60) days after the date of his termination, then, subject to Executive’s
compliance with Section 8, Executive shall receive severance pay (less applicable withholding taxes) at a rate equal to his Base Salary rate, as then in effect, for a period of six (6) months from the date such release of claims becomes
effective (such payments shall he paid periodically in accordance with the Company’s normal payroll policies). If Executive becomes entitled to receive severance pay pursuant to this Section 5(a), Executive will not be entitled to any
other severance benefits or similar payments in accordance with the Company’s established policies as then in effect. 

(b) Voluntary Termination; Termination for Cause. If Executive’s employment with the Company is terminated voluntarily by
Executive or for Cause by the Company, then (i) all vesting of any unvested stock options or shares of restricted stock held by Executive as of the date of Executive’s termination of employment will terminate immediately, (ii) all
payments of compensation by the Company to Executive hereunder will terminate immediately (except as to amounts already earned) and (iii) Executive will only be eligible for severance benefits in accordance with the Company’s established
policies as then in effect. 
 (c) Termination by Reason of Death or Disability. If Executive’s employment with the
Company terminates as a result of Executive’s death or Disability (as defined in Section 6 below), Executive or Executive’s estate or representative will receive all salary accrued (plus any other amounts payable as determined by the
Board in its sole discretion) as of the date of Executive’s death or Disability and any other benefits payable under the Company’s then 

  
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existing benefit plans and policies in accordance with such plans and policies in effect on the date of death or Disability and in accordance with applicable law. Such payments shall be made by
the Company periodically in accordance with the Company’s normal payroll policies with respect to each element of such payments. 
 6. Definitions. 
 (a) Cause. For purposes of this Agreement,
“Cause” is defined as (i) a violation of a material written Company policy that is communicated by the Board to Executive and that continues uncured for thirty (30) days, (ii) an act of dishonesty made by Executive in
connection with Executive’s responsibilities, as an employee, (iii) Executive’s conviction of, or plea of nolo contendere to, a felony, (iv) Executive’s gross misconduct, (v) the failure or refusal of Executive
to follow the lawful and proper directives of the Board that are within the scope of the Executive’s duties set forth in Section 1 above and that is not corrected within thirty (30) days after written notice from the Board to
Executive identifying such failure or refusal or (vi) Executive’s material breach of the PIIA (as defined below) or Section 8(b) hereof. 
 (b) Disability. For purposes of this Agreement, “Disability” shall mean that Executive has been unable to perform his duties hereunder as the result of his incapacity due to
physical or mental illness, and such inability, which continues for at least 120 consecutive calendar days or 150 calendar days during any consecutive twelve-month period, is determined to be total and permanent by a physician selected by the
Company and its insurers and acceptable to Executive or to Executive’s legal representative (with such agreement on acceptability not to be unreasonably withheld). 
 (c) Good Reason. For purposes of this Agreement, “Good Reason” shall mean if (A) there is (1) a material, adverse and permanent change in Executive’s position as set
forth in Section 1(a) of this Agreement causing such position to be of materially reduced stature or responsibility (other than changes related to Executive’s termination as the Senior Vice President and General Manager, Diagnostics),
(2) a reduction of more than five percent (5%) in Executive’s Base Salary then in effect (other than any such reduction applicable to officers of the Company generally), (3) a material reduction by the Company in the kind or
level of employee benefits (other than Base Salary) to which Executive is entitled immediately prior to such reduction with the result that Executive’s overall benefits package (other than Base Salary) is substantially reduced (other than any
such reduction applicable to officers of the Company generally), (4) any material breach by the Company of any material provision of this Agreement which continues uncured for thirty (30) days following notice by Executive thereof, or
(5) a refusal by Executive, following a request by the Company, to relocate to a facility or location more than forty (40) miles from the Company’s current location, and (B) Executive provides notice to the Company within
thirty (30) days after the initial occurrence of the condition or event described above, the Company fails to cure or remedy any such condition or event within the thirty (30) day period following its receipt of the notice, and Executive
thereafter elects to terminate his employment voluntarily within thirty (30) days after the expiration of the period for 

  
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correcting such condition or event; provided, however, that none of the foregoing shall constitute Good Reason to the extent that Executive has agreed in writing to such material
change, reduction, breach or refusal, and provided further that any change in Executive’s job function or responsibilities in order to accommodate a disability under the Americans with Disabilities Act, the Family Medical Leave Act or
any analogous statute or law shall not constitute a basis for Executive to involuntarily terminate his employment hereunder. 

(d) Involuntary Termination. For purposes of this Agreement, an “Involuntary Termination” shall be deemed to
occur if: (i) Executive’s employment with the Company is terminated by the Company for any reason other than Cause (and for a reason other than Executive’s death or Disability); or (ii) Executive terminates his employment with
the Company for Good Reason. 
 7. Proprietary Information and Inventions Agreement. Executive acknowledges that he is
and will continue to be bound by the terms and conditions of the Proprietary Information and Inventions Agreement (the “PIIA”), a copy of which is attached hereto as Exhibit A. 

8. Conditional Nature of Severance Payments. 
 (a) Non-Solicitation; Non-Competition. Executive agrees and acknowledges that Executive’s right to receive the severance benefits set forth in Section 5 (to the extent Executive is
otherwise entitled to such benefits) shall be conditioned upon Executive’s continued compliance with Section 8 (Non-Solicitation) and Section 9 (Non-Competition) of the PIIA and Section 8(b) of this Agreement. Upon any breach of
this section, all severance benefits pursuant to this Agreement shall immediately cease including, without limitation, Executive’s right to exercise any stock options on a date that is more than ninety (90) days after the date that
Executive’s employment was terminated. 
 (b) Non-Disparagement. During and after the Employment Term, Executive
agrees to refrain from any defamation, libel or slander of the Company and its officers, directors, employees, agents, investors, stockholders, administrators, affiliates, divisions, subsidiaries, predecessor and successor corporations, and assigns,
and any tortuous interference with the contracts, relationships and prospective economic advantage of any of the foregoing persons and entities. 
 (c) Understanding of Covenants. Executive represents that he (i) is familiar with the covenants set forth in Section 8 and Section 9 of the PIIA, and (ii) is fully aware of his
obligations hereunder, including, without limitation, the reasonableness of the length of time, scope and geographic coverage of such covenants. 
 9. Confidentiality of Terms. Executive agrees to follow the Company’s strict policy that employees must not disclose, either directly or indirectly, any of the terms of this Agreement to any
person, including other employees of the Company; provided, however, that Executive may 

  
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discuss such terms with members of Executive’s immediate family and any legal, tax or accounting specialists who provide Executive with individual legal, tax or accounting advice.

 10. Assignment. This Agreement will be binding upon and inure to the benefit of (a) the heirs, executors and
legal representatives of Executive upon Executive’s death and (b) any successor of the Company. Any such successor of the Company will be deemed substituted for the Company under the terms of this Agreement for all purposes. For this
purpose, “successor” means any person, firm, corporation or other business entity which at any time, whether by purchase, merger or otherwise, directly or indirectly acquires all or substantially all of the assets or business of the
Company. None of the rights of Executive to receive any form of compensation payable pursuant to this Agreement may be assigned or transferred except by will or the laws of descent and distribution. Any other attempted assignment, transfer,
conveyance or other disposition of Executive’s right to compensation or other benefits will be null and void. 
 11.
Notices. All notices, requests, demands and other communications called for hereunder shall be in writing and shall be deemed given (a) on the date of delivery if delivered personally, (b) one (1) day after being sent by a well
established commercial overnight service, or (c) four (4) days after being mailed by registered or certified mail, return receipt requested, prepaid and addressed to the parties or their successors at the following addresses, or at such
other addresses as the parties may later designate in writing: 
 If to the Company: 

NanoString Technologies, Inc. 
 530 Fairview Ave. N., Suite 2000 
 Seattle, WA 98109 

Attn: CEO 
 If to Executive: 
 to the last residential address known by the
Company. 
 12. Severability. In the event that any provision hereof becomes or is declared by a court of competent
jurisdiction to be illegal, unenforceable or void, this Agreement will continue in full force and effect without said provision. 
 13. Application of Section 409A. Notwithstanding anything to the contrary set forth herein, any payments and benefits provided under this Agreement that constitute “deferred
compensation” within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) and the regulations and other guidance thereunder and any state law of similar effect (collectively, the
“Section 409A”) shall not commence in connection will Executive’s termination of employment unless and until Executive has also incurred a “separation from service” (as such term is defined in Treasury Regulation
Section 1.409A-1(h) (the “Separation From Service”), unless the Company reasonably determines that such amounts 

  
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may be provided to Executive without causing Executive to incur the additional 20% tax under Section 409A. 
 It is intended that each installment of severance pay provided for in this Agreement is a separate “payment” for purposes of Treasury Regulation Section 1.409A-2(b)(2)(i). For the avoidance
of doubt, it is intended that severance payments set forth in this Agreement satisfy, to the greatest extent possible, the exceptions from the application of Section 409A provided under Treasury Regulation Sections 1.409A-1(b)(4) and
1.409A-1(b)(9). 
 If the Company (or, if applicable, the successor entity thereto) determines that any payments or benefits
constitute “deferred compensation” under Section 409A and Executive is, on the termination of service, a “specified employee” of the Company or any successor entity thereto, as such term is defined in
Section 409A(a)(2)(B)(i) of the Code, then, solely to the extent necessary to avoid the incurrence of the adverse personal tax consequences under Section 409A, the timing of the payments and benefits shall be delayed until the earlier to
occur of: (a) the date that is six months and one day after Executive’s Separation From Service, or (b) the date of Executive’s death (such applicable date, the “Specified Employee Initial Payment Date”). On the
Specified Employee Initial Payment Date, the Company (or the successor entity thereto, as applicable) shall (i) pay to Executive a lump sum amount equal to the sum of the payments and benefits that Executive would otherwise have received
through the Specified Employee Initial Payment Date if the commencement of the payment of such amounts had not been so delayed pursuant to this Section and (ii) commence paying the balance of the payments and benefits in accordance with the
applicable payment schedules set forth in this Agreement. 
 14. Arbitration. 

(a) General. In consideration of Executive’s service to the Company, his promise to arbitrate all employment related disputes
and Executive’s receipt of the compensation, pay raises and other benefits paid to Executive by the Company, at present and in the future, Executive agrees that any and all controversies, claims, or disputes with anyone (including the Company
and any employee, officer, director, stockholder or benefit plan of the Company in their capacity as such or otherwise) arising out of, relating to, or resulting from Executive’s service to the Company under this Agreement or otherwise or the
termination of Executive’s service with the Company, including any breach of this Agreement, shall be subject to binding arbitration under the Arbitration Rules set forth in the Revised Code of Washington Chapter 7.04 (the
“Rules”) and pursuant to Washington law. Disputes which Executive agrees to arbitrate, and thereby agrees to waive any right to a trial by jury, include any statutory claims under state or federal law, including, but not limited to,
claims under Title VII of the Civil Rights Act of 1964, the Americans with Disabilities Act of 1990, the Age Discrimination in Employment Act of 1967, the Older Workers Benefit Protection Act, claims of harassment, discrimination or wrongful
termination. Executive further understands that this Agreement to arbitrate also applies to any disputes that the Company may have with Executive. 

  
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 (b) Procedure. Executive agrees that any arbitration will be administered by the
American Arbitration Association (“AAA”) and that a neutral arbitrator will be selected in a manner consistent with its National Rules for the Resolution of Employment Disputes. The arbitration proceedings will allow for discovery
according to the National Rules for the Resolution of Employment Disputes and the Washington Code of Civil Procedure. Executive agrees that the arbitrator shall have the power to decide any motions brought by any party to the arbitration, including
motions for summary judgment and/or adjudication and motions to dismiss and demurrers, prior to any arbitration hearing. Executive agrees that the arbitrator shall issue a written decision on the merits with findings of fact and conclusions of law.
Executive also agrees that the arbitrator shall have the power to award any remedies, including attorneys’ fees and costs, available under applicable law. Executive understands the Company will pay for any administrative or hearing fees charged
by the arbitrator or AAA except that Executive shall pay the first $200.00 of any filing fees associated with any arbitration Executive initiates. Executive agrees that the arbitrator shall administer and conduct any arbitration in a manner
consistent with the Rules and that to the extent that the AAA’s National Rules for the Resolution of Employment Disputes conflict with the Rules, the Rules shall take precedence. 

(c) Remedy. Except as provided by the Rules, arbitration shall be the sole, exclusive and final remedy lot any dispute between
Executive and the Company. Accordingly, except as provided for by the Rules, neither Executive nor the Company will be permitted to pursue court action regarding claims that are subject to arbitration. Notwithstanding, the arbitrator will not have
the authority to disregard or refuse to enforce any lawful Company policy, and the arbitrator shall not order or require the Company to adopt a policy not otherwise required by law which the Company has not adopted. 

(d) Availability of Injunctive Relief. In addition to the right under the Rules to petition the court for provisional relief,
Executive agrees that any party may also petition the court for injunctive relief where either party alleges or claims a violation of this Agreement or the PIIA or any other agreement regarding trade secrets, confidential information,
non-competition, non-solicitation or non-disparagement. In the event either party seeks injunctive relief the prevailing party shall be entitled to recover reasonable costs and attorneys’ fees. 

(e) Administrative Relief. Executive understands that this Agreement does not prohibit Executive from pursuing an administrative
claim with a local, state or federal administrative body such as the Washington State Human Rights Commission, Equal Employment Opportunity Commission or the workers’ compensation board. This Agreement does, however, preclude Executive from
pursuing court action regarding any such claim. 
 15. Voluntary Nature of Agreement. Executive acknowledges and agrees
that Executive is executing this Agreement voluntarily and without any duress or undue influence by the Company or any other person. Executive further acknowledges and agrees that Executive has carefully read this Agreement and that Executive has
asked any questions needed for Executive to understand the terms, consequences and binding effect of this Agreement and fully understand 

  
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it, including that Executive is waiving Executive’s right to a jury trial. Finally, Executive agrees that Executive has been provided an opportunity to seek the advice of an attorney of
Executive’s choice before signing this Agreement. 
 16. Integration. This Agreement, any stock option and
restricted stock agreements between the Company and Executive and the PIIA represent the entire agreement and understanding between the parties as to the subject matter herein and supersede all prior or contemporaneous agreements whether written or
oral. No waiver, alteration, or modification of any of the provisions of this Agreement will be binding unless in writing and signed by duly authorized representatives of the parties hereto. 

17. Tax Withholding. All payments made pursuant to this Agreement will be subject to withholding of applicable taxes. 

18. Governing Law. This Agreement will be governed by the laws of the State of Washington, without giving effect to principles of
conflict of laws. 
 IN WITNESS WHEREOF, the parties have executed this Agreement as of the day and year first above written.

  

			
	COMPANY:
	
	NANOSTRING TECHNOLOGIES, INC.
		
	By:	 	/s/ Wayne Burns
	Print Name: Wayne Burns
	Title: CFO

  

	
	EXECUTIVE:
	
	/s/ Bruce Seeley
	Bruce Seeley

  
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 Attachment A 
 NANOSTRING TECHNOLOGIES, INC. 
 PROPRIETARY INFORMATION AND INVENTIONS
AGREEMENT 
 (WASHINGTON EMPLOYEES) 
 In consideration for my becoming, employed (or my employment being continued), or retained as a consultant (or my consulting relationship being continued), by NanoString Technologies, Inc. or any of its
current or future subsidiaries, affiliates, successors or assigns (collectively, the “Company”), the Company and I hereby agree as follows: 
 1. Duties. I will perform for the Company such duties as may be designated by the Company from time to time. During my period of employment or consulting relationship with the Company, I
will devote my best efforts to the interests of the Company and will not engage in other employment or in any activities detrimental to the best interests of the Company without the prior written consent of the Company. 

2. Confidentiality Obligation. I understand and agree that all Proprietary Information (as defined below) shall be the sole
property of the Company and its assigns, including all trade secrets, patents, copyrights and other rights in connection therewith. I hereby assign to the Company any rights I may acquire in such Proprietary Information. I will hold in confidence
and not directly or indirectly to use or disclose, both during my employment by or consulting relationship with the Company and after its termination (irrespective of the reason for such termination), any Proprietary Information I obtain or create
during the period of my employment or consulting relationship, whether or not during working hours, except to the extent authorized by the Company, until such Proprietary Information becomes generally known. I agree not to make copies of such
Proprietary Information except as authorized by the Company. Upon termination of my employment or consulting relationship or upon an earlier request of the Company, I will return or deliver to the Company all tangible forms of such Proprietary
Information in my possession or control, including but not limited to drawings, specifications, documents, records, devices, models or any other material and copies or reproductions thereof. 

3. Ownership of Physical Property. All document, apparatus, equipment and other physical property in any form, whether or
not pertaining to Proprietary Information, furnished to me by the Company or produced by me or others in connection with my employment or consulting relationship shall be and remain the sole property of the Company. I shall return to the Company all
such documents, materials and property as and when requested by the Company, except only (i) my personal copies of records relating to my compensation; (ii) if applicable, my personal copies of any materials evidencing shares of the
Company’s capital stock purchased by me and/or options to purchase shares of the Company’s capital stock granted to me; (iii) my copy of this Agreement and (iv) my personal property and personal documents I bring with me to the
Company and any personal correspondence and personal materials that I accumulate and keep at my office during my employment (my “Personal Documents”). Even if the Company does not so

  
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request, I shall return all such documents, materials and property upon termination of my employment or consulting relationship, and, except for my Personal Documents, I will not take with me any
such documents, material or property or any reproduction thereof upon such termination. 
 4. Assignment of
Inventions. 
 (a) Without further compensation, I hereby agree promptly to disclose to the Company, all Inventions (as
defined below) which I may solely or jointly develop or reduce to practice during the period of my employment or consulting relationship with the Company which (i) pertain to any line of business activity of the Company, (ii) are aided by
the use of time, material or facilities of the Company, whether or not during working hours or (iii) relate to any of my work during the period of my employment or consulting relationship with the Company, whether or not during normal working
hours (“Company Inventions”). During the term of my employment or consultancy, all Company Inventions that I conceive, reduce to practice, develop or have developed (in whole or in part, either alone or jointly with others) shall be
the sole property of the Company and its assigns to the maximum extent permitted by law (and to the fullest extent permitted by law shall be deemed “works made for hire”), and the Company and its assigns shall be the sole owner of all
patents, copyrights, trademarks, trade secrets and other rights in connection therewith. I hereby assign to the Company any rights that I may have or acquire in such Company Inventions. 

(b) I attach hereto as Exhibit A a complete list of all Inventions, if any, made by me prior to my employment or consulting
relationship with the Company that are relevant to the Company’s business, and I represent and warrant that such list is complete. If no such list is attached to this Agreement, I represent that I have no such Inventions at the time of signing
this Agreement. If in the course of my employment or consultancy (as the case may be) with the Company, I use or incorporate into a product or process an Invention not covered by Section 4(a) of this Agreement in which I have an interest, the
Company is hereby granted a nonexclusive, fully paid-up, royally-free, perpetual, worldwide license of my interest to use and sublicense such Invention without restriction of any kind. 

NOTICE REQUIRED BY REVISED CODE OF WASHINGTON 49.44.140: 

Any assignment of Inventions required by this Agreement does not apply to an Invention for which no equipment, supplies, facility or
trade secret information of the Company was used and which was developed entirely on the employee’s own time, unless (a) the Invention relates (i) directly to the business of the Company or (ii) to the Company’s actual or
demonstrably anticipated research or development or (b) the Invention results from any work performed by the employee for the Company. 
 5. Further Assistance; Power of Attorney. I agree to perform, during and after my employment or consulting relationship, all acts deemed necessary or desirable by the Company

  
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to permit and assist it, at its expense, in obtaining and enforcing the full benefits, enjoyment, rights and title throughout the world in the Inventions assigned to the Company as set forth in
Section 4 above. Such acts may include, but are not limited to, execution of documents and assistance or cooperation in legal proceedings. I hereby irrevocably designate the Company and its duly authorized officers and agents as my agent and
attorney-in fact, to execute and file on my behalf any such applications and to do all other lawful acts to further the prosecution and issuance of patents, copyright and mask work registrations related to such Inventions. This power of attorney
shall not be affected by my subsequent incapacity. 
 6. Inventions. As used in this Agreement, the term
“Inventions” means discoveries, developments, concepts, designs, ideas, know-how, improvements, inventions, trade secrets and/or original works of authorship, whether or not patentable, copyrightable or otherwise legally
protectable. This includes, but is not limited to, any new product, machine, article of manufacture, biological material, method, procedure, process, technique, use, equipment, device, apparatus, system, compound, formulation, composition of matter,
design or configuration of any kind, or any improvement thereon. 
 7. Proprietary Information. As used in this
Agreement, the term “Proprietary Information” means information or physical material not generally known or available outside the Company or information or physical material entrusted to the Company by third parties. This includes,
but is not limited to, Inventions, confidential knowledge, copyrights, product ideas, techniques, processes, formulas, object codes, biological materials, mask works and/or any other information of any type relating to documentation, laboratory
notebooks, data, schematics, algorithms, flow charts, mechanisms, research, manufacture, improvements, assembly, installation, marketing, forecasts, sales, pricing, customers, the salaries, duties, qualifications, performance levels and terms of
compensation of other employees, and/or cost or other financial data concerning any of the foregoing of the Company and its operations. Proprietary Information may be contained in material such as drawings, samples, procedures, specifications,
reports, studies, customer or supplier lists, budgets, cost or price lists, compilations or computer programs, or may be in the nature of unwritten knowledge or know-how. 
 8. Solicitation of Employees, Consultants, and Other Parties. During the term of my employment or consulting relationship with the Company, and for a period of one year following the
termination of my relationship with the Company for any reason, I will not directly or indirectly solicit, induce, recruit or encourage any of the Company’s employees or consultants to terminate their relationship with the Company, or attempt
any of the foregoing, either for myself or any other person or entity. Further, at any time following termination of my relationship with the Company for any reason, I shall not use any Proprietary Information of the Company to attempt to negatively
influence any of the Company’s clients or customers from purchasing any of the Company’s products or services, or solicit any licensor to or customer of the Company or licensee of the Company’s products, that are known to me, with
respect to any business, products or services that are competitive to the products or services offered by the 

  
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Company or under development as of the date of termination of my relationship with the Company. 
 9. Noncompetition. During the term of my employment or consulting relationship with the Company and for one year following the termination of my relationship with the Company for any reason,
I will not, without the Company’s prior written consent, directly or indirectly work on any products or services that are competitive with products or services (a) being commercially developed or exploited by the Company during my
employment or consultancy and (b) on which I worked or about which I learned Proprietary Information during my employment or consultancy with the Company. 
 10. No Conflicts. I represent that my performance of all the terms of this Agreement as an employee of or consultant to the Company does not and will not breach any agreement to keep in
confidence proprietary information, knowledge of data acquired by me in confidence or in trust prior to my becoming an employee or consultant of the Company, and I will not disclose to the Company, or induce the Company to use, any confidential or
proprietary information or material belonging to any previous employer or others. I agree not to enter into any written or oral agreement that conflicts with the provisions of this Agreement. 

11. No Interference. I certify that, to the best of my information and belief, I am not a party to any other agreement
which will interfere with my full compliance with this Agreement. 
 12. Effects of Agreement. This Agreement
(a) shall survive for a period of five years beyond the termination of my employment by or consulting relationship with the Company, (b) inures to the benefit of successors and assigns of the Company and (c) is binding upon my heirs
and legal representatives. 
 13. At-Will Relationship. I understand and acknowledge that my employment or
consulting relationship with the Company is and shall continue to be at-will, as defined under applicable law, meaning that either I or the Company may terminate the relationship at any time for any reason or no reason, without further obligation or
liability. 
 14. Injunctive Relief. I acknowledge that violation of this Agreement by me may cause irreparable
injury to the Company, and I agree that the Company will be entitled to seek extraordinary relief in court, including, but not limited to, temporary restraining orders, preliminary injunctions and permanent injunctions without the necessity of
posting a bond or other security and without prejudice to any other rights and remedies that the Company may have for a breach of this Agreement. 
 15. Miscellaneous. This Agreement supersedes any oral, written or other communications or agreements concerning the subject matter of this Agreement, and may be amended or waived only by a
written instrument signed by me and the Chief Executive Officer 

  
 -13-

 
of the Company. This Agreement shall be governed by the laws of the State of Washington applicable to contracts entered into and performed entirely within the State of Washington, without giving
effect to principles of conflict of laws. If any provision of this Agreement is held to be unenforceable under applicable law, then such provision shall be excluded from this Agreement only to the extent unenforceable, and the remainder of such
provision and of this Agreement shall be enforceable in accordance with its terms. 
 16. Acknowledgment. I
certify and acknowledge that I have carefully read all of the provisions of this Agreement and that I understand and will fully and faithfully comply with such provisions. 
 The undersigned have executed this Proprietary Information and Inventions Agreement as of the date set forth below. 
  

			
	COMPANY:
	
	NANOSTRING TECHNOLOGIES INC.
		
	By:	 	/s/ Wayne Burns
	Print Name: Wayne Burns
	Title: CFO

  

	
	EXECUTIVE:
	
	/s/ Bruce Seeley
	Bruce Seeley

  
 -14-

 Exhibit A 

Nanostring Technologies, Inc. 
 530 Fairview Ave N. Suite 2000 
 Seattle, WA 98109 

Ladies and Gentlemen: 
 1. The following is a complete list of all Inventions relevant to the subject matter of my employment by the Company that have been made or conceived or first reduced to practice by me, alone or jointly
with others or which has become known to me prior to my employment by the Company. I represent that such list is complete. 
 2.
I propose to bring to my employment or consultancy the following materials and documents of a former employer: 
  

	 	x	No materials or documents. 

  

	 	 ̈	See below: 

  

			
		
	By:	 	/s/ Bruce Seeley
		 	Bruce Seeley

  
 -15-

 NANOSTRING TECHNOLOGIES, INC. 

AMENDMENT TO EMPLOYMENT AGREEMENT 
 This amendment (the “Amendment”) is made by and between Bruce Seeley (“Executive”) and NanoString Technologies, Inc. (the “Company,” and together with
Executive, the “Parties”) on the dates set forth below. 
 WHEREAS, the Parties entered into an
employment agreement effective May 18, 2012 (the “Employment Agreement”); 
 WHEREAS, the Company
and Executive desire to amend certain provisions of the Employment Agreement in order to clarify the timing of the severance payment, as set forth below, in accordance with Section VI.B.3 of Internal Revenue Service Notice 2010-6, as amended by
Internal Revenue Service Notice 2010-80. 
 NOW, THEREFORE, for good and valuable consideration, Executive and the
Company agree that the Employment Agreement is hereby amended as follows. 
 1. Section 409A. Section 13 of the
Employment Agreement is hereby amended to insert the following paragraph immediately following the first paragraph thereof: 
 “Any severance payments or benefits under this Agreement that would be considered “deferred compensation” under Section 409A will be paid on, or, in the case of installments, will not
commence until, the sixtieth (60th) day following
Executive’s Separation From Service, of, if later, such time is required by the final paragraph of this Section 13. Except as required by the final paragraph of this Section 13, any installment payments that would have been made to
Executive during the 60 day period immediately following Executive’s Separation From Service but for the preceding sentence will be paid to Executive on the sixtieth (60th) day following Executive’s Separation from Service and the remaining payments shall be made as provided in
this Agreement.” 
 2. Full Force and Effect. To the extent not expressly amended hereby, the Agreement shall remain
in full force and effect. 
 3. Entire Agreement. This Amendment and the Agreement constitute the full and entire
understanding and agreement between the Parties with regard to the subjects hereof and thereof. This Amendment may be amended at any time only by mutual written agreement of the Parties. 

4. Counterparts. This Amendment may be executed in counterparts, all of which together shall constitute one instrument, and each
of which may be executed by less than all of the parties to this Amendment. 
 5. Governing Law. This Amendment will be
governed by the laws of the State of Washington (with the exception of its conflict of laws provisions). 

 IN WITNESS WHEREOF, each of the Parties has executed this Amendment, in the case of
the Company by its duly authorized officer, on the dates set forth below. 
  

									
	NANOSTRING TECHNOLOGIES, INC.	 		 	Bruce Seeley
			
	/s/ Wayne Burns	 		 	 /s/ Bruce Seeley

	Wayne D. Burns	 		 		 	
					
	By:	 	Sr. VP, Operations & Administration	 		 		 	
					
	Date:	 	12/26/12	 		 	Date:	 	12/26/12Lease Agreement between Registrant and BMR-530 Fairview Avenue LLC

 Exhibit 10.11 
 EXECUTION VERSION 
 LEASE 

by and between 

BMR-530 FAIRVIEW AVENUE LLC, 
 a Delaware limited liability company 
 and 

NANOSTRING TECHNOLOGIES, INC., 
 a Delaware corporation 

 LEASE 
 THIS LEASE (this “Lease”) is entered into as of this 19th day of October, 2007 (the “Execution Date”), by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited
liability company (“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation (“Tenant”). 
 RECITALS 
 A. WHEREAS, Landlord owns certain real property (the
“Property”) located at 530 Fairview Avenue in Seattle, Washington, and intends to construct a building located thereon (the “Building”) in which the Premises (as defined below) shall be located; and 

B. WHEREAS, Landlord wishes to lease to Tenant, and Tenant desires to lease from Landlord, certain premises (the
“Premises”) consisting of (a) the entire second floor of the Building and (b) storage rooms 107 and 109 of the Building (the “Storage Rooms”) pursuant to the terms and conditions of this Lease, as detailed
below. 
 AGREEMENT 
 NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged,
and intending to be legally bound, agree as follows: 
 1. Lease of Premises. Effective on the Term Commencement Date,
Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, the Premises, as shown on Exhibit A attached hereto for use by Tenant in accordance with the Permitted Use (as defined below) and no other uses. The Premises
comprise the entire second (2nd) floor of the Building. The Property and all landscaping, parking facilities and other improvements and appurtenances related thereto, including, without limitation, the Building, are hereinafter collectively
referred to as the “Project.” All portions of the Project that are for the non-exclusive use of tenants of the Building, including, without limitation, driveways, sidewalks, parking areas, landscaped areas, service corridors,
stairways, elevators, public restrooms and public lobbies, are hereinafter referred to as “Common Area.” 

Tenant and Cell Therapeutics, Inc. (“CTI”) are parties to that certain Sublease dated October 6, 2004, as amended,
under which Tenant subleases from CTI certain premises located at 201 Elliott Avenue West, Seattle, Washington (“Sublease Premises”). CTI leases the Sublease Premises from BMR-201 Elliot Avenue LLC (“Master
Landlord”). This Lease is contingent upon the simultaneous full execution by Tenant and Master Landlord of an agreement in the form of the attached Exhibit J. 

 2. Basic Lease Provisions. For convenience of the parties, certain basic provisions
of this Lease are set forth herein. The provisions set forth herein are subject to the remaining terms and conditions of this Lease and are to be interpreted in light of such remaining terms and conditions. 

2.1 This Lease shall take effect upon the Execution Date and, except as specifically otherwise provided within this Lease, each of the
provisions hereof shall be binding upon and inure to the benefit of Landlord and Tenant from the date of execution and delivery hereof by all parties hereto. 
 2.2 In the definitions below, each current Rentable Area (as defined below) is expressed in rentable square footage. Rentable Area and Tenant’s Pro Rata Share are both subject to adjustment as
provided in this Lease. 
  

					
	 Definition or Provision
	  	Means the Following (As of the Term
Commencement Date)	 
		
	 Approximate Rentable Area of Premises (without the Expansion Premises)
	  	 	16,852 square feet	  
		
	 Approximate Rentable Area of Building
	  	 	95,849 square feet	  
		
	 Approximate Tenant’s Pro Rata Share of Building (without the Expansion Premises)
	  	 	17.60	% 

 2.3 Basic Annual Rent for the Premises (“Basic Annual Rent”) shall be $51.00 per square
foot of Rentable Area of the Premises, subject to adjustment under this Lease. Initial monthly and annual installments of Basic Annual Rent as of the Rent Commencement Date, subject to adjustment under this Lease: 

 

													
	 	  	Rentable Area	  	Per S.F. of
Rentable Area	  	Approximate
Total Annual	 	  	Approximate
Total Monthly	 
	 Premises (without the Expansion Premises)
	  	Approximately
16,852 square feet	  	$51.00 annually	  	$	859,452	  	  	$	71,621.00	  

 2.4 Estimated Delivery Date: June 1, 2008 

2.5 Term Commencement Date: The later to occur of (i) Substantial Completion (as defined below) of the Core and Shell Work and the
Tenant Improvements, or (ii) July 1, 2008 
 2.6 Term Expiration Date: Five (5) years after the Rent Commencement
Date; provided, however, Tenant shall have the option to extend this Lease as provided in Article 42 
 2.7 Rent
Commencement Date: One hundred eighty (180) days after the Term Commencement Date 

  
 -2-

 2.8 Security Deposit: An amount equal to Basic Annual Rent for the first full month after
the Rent Commencement Date ($67,681.25), subject to increase in accordance with the terms hereof 
 2.9 Permitted Use:

 (a) Second Floor Portion of Premises: General office and laboratory use in conformity with Applicable Laws (as defined
below) 
 (b) Storage Rooms Portion of Premises: General storage use 

 

					
		 	2.10 Address for Rent Payment:	 	BMR-530 Fairview Avenue LLC
		 		 	17140 Bernardo Center Drive, Suite 222
		 		 	San Diego, California 92128

  

					
		 	2.11 Address for Notices to Landlord:	 	 BMR-530 Fairview Avenue LLC

17140 Bernardo Center Drive, Suite 222
 San
Diego, California 92128
 Attn: General Counsel/Real Estate

 2.12 Address for Notices to Tenant: 

 

			
	Prior to the Term Commencement Date:	  	Nanostring Technologies, Inc.
		  	201 Elliot Avenue West
		  	Seattle, Washington
		  	Attn: CFO
		
	With a copy to:	  	Heller Ehrman
		  	701 Fifth Avenue
		  	Suite 6100
		  	Seattle, Washington
		  	Attn: Sonya Erikson
		
	After the Term Commencement Date	  	Nanostring Technologies, Inc.
		  	Suite 2000
		  	530 Fairview Avenue
		  	Seattle, WA
		  	Attn: CFO
		
	With a copy to:	  	Heller Ehrman
		  	701 Fifth Avenue
		  	Suite 6100
		  	Seattle, Washington
		  	Attn: Sonya Erikson

  
 -3-

 2.13 The following Exhibits are attached hereto and incorporated herein by reference:

  

			
	Exhibit A	  	Premises
	Exhibit B	  	Acknowledgement of Term Commencement Date and Term Expiration Date
	Exhibit C	  	[Intentionally Deleted]
	Exhibit D	  	Rules and Regulations
	Exhibit E	  	Form of Estoppel Certificate
	Exhibit F	  	[Intentionally Deleted]
	Exhibit G	  	Work Letter
	Exhibit H	  	Form of Letter of Credit
	Exhibit I	  	Form of Additional TI Allowance Acceptance Letter
	Exhibit J	  	Form of Holdover Side Letter
	Exhibit K	  	[Intentionally Deleted]
	Exhibit L	  	Warm Shell Costs

 3. Term. 
 3.1 The actual term of this Lease (the “Term”) shall be that period from the actual Term Commencement Date (as defined in Section 2.5 above) through the Term Expiration Date,
subject to earlier termination of this Lease as provided herein. 
 4. Core and Shell Work and Tenant Improvements.

 4.1 Shell and Core Construction of Building. 

4.1.1 Commencement of Core and Shell Work. Landlord shall, at Landlord’s sole cost and expense (except that Tenant shall pay
(as a deduction against the TI Allowance) Tenant’s Pro Rata Share of the costs incurred by Landlord in performing, or causing to be performed, the work described on, or necessary to cause the Building to comply with the requirements set forth
on, or the depiction of the warm shell which is attached hereto as Exhibit L, including the costs of design, permitting and construction in connection therewith (such costs, the “Warm Shell Costs”)), cause
Landlord’s contractor, M.A. Mortenson or such replacement thereof as Landlord may make from time to time (“Core and Shell Contractor”), to diligently prosecute the construction of the core and shell of the Building to
completion pursuant to the Approved Core and Shell Plans (as defined in the Work Letter), subject only to Core and Shell Permitted Changes (as defined in the Work Letter attached hereto as Exhibit G), (all such construction,
collectively, “Core and Shell Work”). Core and Shell Work shall be performed in a workmanlike manner, and shall confoun with Applicable Laws. The commencement and completion of Core and Shell Work shall be subject to delays
resulting from acts of Tenant or Force Majeure. “Force Majeure” shall mean acts of God; acts of terrorism; adverse weather conditions; war; invasion; insurrection; acts of a public enemy; terrorism; riot; mob violence; civil
commotion; sabotage; strikes, lockouts or other labor disputes; inability to procure or general shortage of labor, materials, facilities, equipment or supplies on the open market; delay in transportation; laws, rules, regulations or orders of any

  
 -4-

 
Governmental Authority; moratorium or other governmental action; inability to obtain permits or approvals, including, without limitation, city and public utility approvals; the acts or inaction
of the contractor and subcontractors, if any; or any other cause beyond the reasonable control of Landlord, financial ability excepted, whether similar or dissimilar to the foregoing. 

4.1.2 Completion of Construction. Core and Shell Work shall be deemed “Substantially Complete” or there shall be
“Substantial Completion” if Landlord has (a) completed all of the Core and Shell Work identified on the Approved Core and Shell Plans (subject only to such incomplete or defective work as will not materially or adversely impact
Tenant’s use of the Premises (collectively, the “Punchlist Items”)) and (b) received a temporary or other certificate of occupancy from the applicable municipal authority(ies) or a certificate of substantial completion
from the architect. Landlord and Tenant shall work together in the thirty (30) days following Landlord’s Substantial Completion of the Core and Shell Work to develop the list of Punchlist Items, which Landlord shall use good faith,
diligent efforts to complete diligently. Landlord shall endeavor in good faith to cause the Contractor to fix any defects in the Core and Shell Work. 
 4.2 Tenant Improvements. Landlord shall cause the Core and Shell Contractor or another Contractor designated by Landlord and approved by Tenant, such consent not to be unreasonably withheld or
delayed (“TI Contractor”, and together with Core and Shell Contractor, “Contractor”) to commence and thereafter diligently prosecute the construction of the tenant improvements in the Premises pursuant to the Work
Letter (the “Tenant Improvements”); provided, however, that before performing the Tenant Improvements, Landlord shall prepare in good faith an estimated budget for the construction of the Tenant Improvements and
deliver such budget to Tenant for Tenant’s written approval prior the start of construction (the “Budget”). Landlord and Tenant shall work together cooperatively and in good faith to achieve a mutually acceptable Budget.
Landlord shall update the Budget for Tenant’s review and approval at reasonable intervals and shall notify Tenant in writing if the Budget is likely to be exceeded. If there is an indication that the Budget is likely to be exceeded, Landlord
and Tenant shall work together cooperatively, if required by Tenant, to modify the scope of the Tenant Improvements to bring the same in line with a budget reasonably acceptable to Tenant. The Tenant Improvements shall be performed in a workmanlike
manner and shall substantially conform with Applicable Laws and the Approved TI Plans (as defined in the Work Letter). Tenant shall pay all TI Costs, except that Landlord shall pay for TI Costs that do not exceed the TI Allowance. The “TI
Allowance” shall mean (a) One Hundred Twenty Five Dollars ($125.00) per rentable square foot of the Premises (the “Initial TI Allowance”), together with (b) the Additional Allowance. The “TI
Costs” shall mean all Tenant Core and Shell Costs (as defined in the Work Letter) and all costs and expenses of performing the TI Work, including without limitation the hard and soft costs of (i) construction, (ii) the
Construction Management Fee (as such term is defined in the Work Letter) and any Project or construction management fees paid by Tenant to an unaffiliated third party (such fees not to exceed three percent (3%) of the TI Allowance),
(iii) space planning, design, architect, engineering, data and phone cabling and other related services, (iv) costs and expenses for labor, material, equipment, data and phone cabling and fixtures (including, without limitation, any of the
Attached Property (as defined in Section 18.5), (v) building permits and other taxes, fees, charges and levies by governmental and quasi-governmental agencies for permits or for inspections of the Tenant Improvements, and (vi) the

  
 -5-

 
Warm Shell Costs. In no event shall the TI Allowance be used for: (w) the purchase of any furniture, personal property or other non-building system equipment, (x) costs resulting from a
Tenant Delay, (y) costs resulting from any default by Tenant of its obligations under this Lease, or (z) costs that are recoverable or reasonably recoverable by Tenant from a third party (e.g., insurers, warrantors, or tortfeasors). In the
event the estimated total TI Costs (as set forth in the Budget) exceed the TI Allowance, Tenant shall deposit with Landlord such overage (the “TI Allowance Excess”), within five (5) business days of receiving the Budget (the
“TI Deposit”). In the event Landlord determines the estimate of the TI Costs set forth in the Budget underestimates the amount of TI Costs so that the TI Deposit will not be sufficient to cover the TI Allowance Excess, then Landlord
shall communicate the same to Tenant and, if required by Tenant, the parties shall discuss revisions to the Budget and Tenant may make a TI Tenant Change Order Request to reduce TI Costs, and unless the TI Costs are reduced to be within the Budget
and previously paid TI Deposit, Tenant shall promptly pay the additional amount to Landlord, and such additional amount shall be added to the TI Deposit. If the sum of the TI Allowance plus the TI Deposit is not sufficient to cover the TI Costs,
Tenant shall reimburse Landlord the difference between (a) the TI Costs and (b) the sum of the TI Allowance and the TI Deposit. However, Landlord shall be solely responsible for any costs related to the Tenant Improvements to the extent
the same result from Landlord’s gross negligence, intentional misconduct or breach of Lease. Landlord and Tenant shall work together cooperatively at no cost or risk to Landlord to maximize Tenant’s ability, to the extent reasonably
possible, to obtain the benefit of any applicable research and development tax credits with respect to the Tenant Improvements. 
 4.2.1 Architects, Contractors and Consultants. The architect, engineering consultants, design team, general contractor and subcontractors responsible for the construction of the Tenant Improvements
shall be selected by Landlord and approved by Tenant, which approval Tenant shall not unreasonably withhold, condition or delay. Landlord shall supervise all such entities and endeavor in good faith to ensure that the same design and construct the
Core and Shell Work and the Tenant Improvements in compliance with this Lease. 
 4.2.2 Completion of Tenant
Improvements. The Tenant Improvements for the Premises shall be deemed “Substantially Complete” or there shall be “Substantial Completion” if Landlord has completed all of the respective Tenant Improvements
identified on the Approved TI Plans (subject only to the Punchlist Items) for such Phase. Landlord and Tenant shall work together in the thirty (30) days following Landlord’s Substantial Completion of the Tenant Improvements to develop the
list of Punchlist Items, which Landlord shall use diligent, good faith efforts to complete diligently. Notwithstanding anything to the contrary, Landlord shall be responsible, at its sole cost, to promptly correct any defects or violations of law
with respect to the Tenant Improvements throughout the Term. 
 4.2.3 Additional Allowance. Landlord shall, at
Tenant’s request, provide an additional tenant improvement allowance not to exceed Fifty Dollars ($50.00) per rentable square foot of the Premises (the “Additional Allowance”), which amount may be used by Tenant to increase the
scope of Core and Shell Work or the Tenant Improvements pursuant to the terms and conditions contained in the Work Letter. In the event Tenant elects to use the Additional Allowance, Tenant 

  
 -6-

 
shall pay to Landlord, as Rent, an amount equal to the drawn portion of the Additional Allowance, amortized over the initial Term at an interest rate of ten percent (10%) per annum. Tenant
shall make payments in respect of the Additional Allowance plus interest thereon in equal monthly installments so that the full amount shall be paid on or before the expiration of the initial Term. Tenant shall pay such amounts with the payment of
Basic Annual Rent for each month. If Tenant has not paid the full amount of the Additional Allowance plus interest thereon at the expiration or earlier termination of this Lease (unless such termination is due to an event of casualty or condemnation
for which Landlord receives sufficient insurance or condemnation proceeds with respect to the Tenant Improvements to fully compensate Landlord for the amortized value thereof as determined by Landlord in good faith), then upon the expiration or
termination of this Lease Tenant shall immediately pay the unpaid portion of such amount to Landlord. The payments Tenant is required to make in respect of the Additional Allowance shall constitute “Additional Rent” in accordance
with Section 6.2 hereof. Tenant shall be entitled to prepay the Additional Allowance at any time, without penalty. 

4.3 Warranties. Landlord shall diligently endeavor to cause Contractor to complete with reasonable promptness the Punchlist Items
and repair with reasonable promptness all defects in the construction of (x) Core and Shell Work in accordance with the Approved Core and Shell Plans, and (y) the Tenant Improvements in accordance with the Approved TI Plans, each as to
which Tenant notifies Landlord in writing (which notice Tenant shall give within nine (9) months after the Term Commencement Date). Except for such items, and except as otherwise set forth in this Lease, Tenant shall be deemed to have accepted
the Premises in the condition delivered to it “As Is,” and Landlord shall have no liability to correct other claimed defects; provided, however, except as to those items that Landlord is required to correct pursuant to this section,
Landlord shall partially assign to Tenant (but without prejudice to any of Landlord’s rights of enforcement) all warranties that it has received under the architect contracts, construction contracts or any subcontract, or from any material
supplier. Landlord agrees to administer any claims in connection with such warranties in a reasonable manner. 
 Notwithstanding
the foregoing, Landlord further warrants that as of the Term Commencement Date the Premises shall (a) substantially comply with all Applicable Laws (defined below); (b) be constructed substantially in conformance with the Approved TI Plans
and Approved Core and Shell Plans; and (c) be watertight. To the extent any of the warranties set forth in the preceding sentence are violated, Landlord shall promptly correct the same at its sole cost. 

4.4 Expiration of TI Allowance Obligations. So long as no uncured Default by Tenant exists, Tenant shall have until June 30,
2009 to expend the unused portion of the TI Allowance, after which date Landlord’s obligation to fund the TI Allowance shall expire. Tenant’s right to use the unused portion of the TI Allowance will terminate if Tenant Defaults and fails
to cure such Default prior to the expiration of any applicable cure period. 
 5. Possession and Rent Commencement Date.

 5.1 Tenant’s Access. From and after the day that is thirty (30) days before the day when Landlord then
expects the Term Commencement Date to occur, Landlord shall permit Tenant 

  
 -7-

 
to enter the Premises in order to inspect the same, move equipment and personal property into the Premises and perform installation or improvement work, so long as Tenant does not interfere with
Landlord’s installation and completion of the Core and Shell Work or Tenant Improvements; provided, however, Tenant shall furnish to Landlord evidence satisfactory to Landlord that insurance coverages required of Tenant under the
provisions of Article 22 are in effect, and such entry shall be subject to all the terms and conditions of this Lease other than the payment of Basic Annual Rent and Operating Expenses. 

5.2 Premises. Landlord shall endeavor to tender possession of the Premises (with the Tenant Improvements and the Core and Shell
Work Substantially Complete) to Tenant on or before the Estimated Delivery Date. If Core and Shell Work or the Tenant Improvements as required pursuant to the terms of the Work Letter are not Substantially Complete on or before the Estimated
Delivery Date for any reason whatsoever, then this Lease shall not be void or voidable, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom and the Term Commencement Date shall not occur until Substantial Completion of
Core and Shell Work and the Tenant Improvements occurs; provided, however, if the satisfaction of the requirements for Substantial Completion of Core and Shell Work or the Tenant Improvements have been delayed by any Tenant Delay, Substantial
Completion of Core and Shell Work and the Tenant Improvements shall be deemed to occur when (as reasonably determined by Landlord) Substantial Completion of Core and Shell Work and the Tenant Improvements would have occurred if such Tenant Delay had
not occurred. Within thirty (30) days after Substantial Completion of Core and Shell Work and the Tenant Improvements, Landlord’s architect shall calculate and certify in writing to Landlord and Tenant the Rentable Area of the Premises in
accordance with Article 9, which calculation must be approved by Landlord and Tenant (both hereby agreeing to act reasonably with respect to granting such approval). “Tenant Delay” shall mean any delay in the
commencement or completion of the Core and Shell Work or the TI Work that results from or arises out of any of the following: (1) delays or failure of Tenant to deliver items in accordance with the Work Letter attached hereto as
Exhibit G; (2) Tenant’s failure to fulfill its obligations as set forth in this Lease or the Work Letter (including any failure to review or approve or disapprove any items in accordance with the Work Letter); (3) delays
caused by Tenant Change Order Requests (as defined in the Work Letter) or TI Tenant Change Order Requests (as defined in the Work Letter); (4) unavailability of materials, components or finishes for Core and Shell Work or the Tenant
Improvements that differ from Landlord’s standard work or that have an unusually long lead-time for delivery; (5) a willful or negligent act or omission of Tenant or Tenant’s Agents that interferes with the progress of the work;
(6) failure of Landlord and Tenant to agree (for any reason, provided Landlord acts in good faith and diligently to work with Tenant with respect to the Budget) on a mutually agreeable Budget within ten (10) calendar days after Landlord
delivers a draft Budget to Tenant or any request by Tenant that the scope of the Tenant Improvements be modified in connection with the Budget; or (7) delays caused by any revision to the Budget or TI Tenant Change Order Request. Landlord shall
endeavor in good faith to provide Tenant with at least thirty (30) days prior written notice of the date when Landlord believes the Term Commencement Date will occur. 
 5.3 Acknowledgement. Landlord and Tenant shall each execute and deliver to the other written acknowledgment of the actual Term Commencement Date and the Term Expiration

  
 -8-

 
Date when such is established, and shall attach it to this Lease as Exhibit B. Failure to execute and deliver such acknowledgement, however, shall not affect the Rent Commencement
Date or Landlord’s or Tenant’s liability hereunder. Failure by Tenant to obtain validation by any medical review board or other similar governmental licensing of the Premises required for the Permitted Use by Tenant shall not serve to
extend the Term Commencement Date. 
 6. Rent. 
 6.1 Commencing on the Rent Commencement Date, Tenant shall pay to Landlord as Basic Annual Rent for the Premises the sums set forth in Section 2.3, subject to the rental adjustments provided
in Article 7 hereof. Basic Annual Rent shall be paid in equal monthly installments as set forth in Section 2.3, subject to the rental adjustments provided in Article 7 hereof, each in advance on the first day of
each and every calendar month during the Term. 
 6.2 In addition to Basic Annual Rent, from and after the Term Commencement
Date, Tenant shall pay to Landlord as additional rent (“Additional Rent”) at times hereinafter specified in this Lease (a) Tenant’s pro rata share, as set forth in Section 2.2 (“Tenant’s Pro Rata
Share”), of Operating Expenses as provided in Article 8 and (b) any other amounts that Tenant assumes or agrees to pay under the provisions of this Lease that are owed to Landlord, including, without limitation, any and all
other sums that may become due by reason of any default of Tenant or failure on Tenant’s part to comply with the agreements, terms, covenants and conditions of this Lease to be performed by Tenant, after notice and the lapse of any applicable
cure periods. 
 6.3 Basic Annual Rent and Additional Rent shall together be denominated “Rent.” Rent shall be paid to
Landlord, without abatement, deduction or offset (except as otherwise set forth in this Lease), in lawful money of the United States of America at the office of Landlord as set forth in Section 2.10 or to such other person or at such
other place as Landlord may from time designate in writing. In the event the Term commences or ends on a day other than the first day of a calendar month, then the Rent for such fraction of a month shall be prorated for such period on the basis of a
thirty (30) day month and shall be paid at the then-current rate for such fractional month. 
 7. Rent Adjustments.
The Basic Annual Rent shall be subject to an annual upward adjustment of three percent (3%) of the then-current Basic Annual Rent. The first such adjustment shall become effective commencing with that monthly rental installment that is due on
or after the first (1st) annual anniversary of the Rent Commencement Date and subsequent adjustments shall become effective on every successive annual anniversary for so long as this Lease continues in effect. 

8. Operating Expenses. 
 8.1 As used herein, the term “Operating Expenses” shall include: 

(a) Government impositions including, without limitation, property tax costs consisting of real and personal property taxes and
assessments (including amounts due under any improvement bond upon the Building or the Project, including the parcel or parcels of real 

  
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property upon which the Building and areas serving such Building are located or assessments in lieu thereof imposed by any federal, state, regional, local or municipal governmental authority,
agency or subdivision (each, a “Governmental Authority”) are levied); taxes on or measured by gross rentals received from the rental of space in the Building; taxes based on the square footage of the Premises, the Building or the
Project, as well as any parking charges, utilities surcharges or any other costs levied, assessed or imposed by, or at the direction of, or resulting from Applicable Laws (as defined below) or interpretations thereof, promulgated by any Governmental
Authority in connection with the use or occupancy of the Building or the parking facilities serving the Building; taxes on this transaction or any document to which Tenant is a party creating or transferring an interest in the Premises; any fee for
a business license to operate an office building; and any expenses, including the reasonable cost of attorneys or experts, reasonably incurred by Landlord in seeking reduction by the taxing authority of the applicable taxes, less tax refunds
obtained as a result of an application for review thereof. Operating Expenses shall not include any net income, franchise, capital stock, estate or inheritance taxes, or taxes that are the personal obligation of Tenant or of another tenant of the
Project; and 
 (b) All other costs of any kind paid or incurred by Landlord in connection with the operation or maintenance of
the Building and the Project including, by way of example and not of limitation, costs of repairs and replacements to improvements within the Project as appropriate to maintain the Project as required hereunder, including costs of funding such
reasonable reserves as Landlord, consistent with good business practice, may establish to provide for future repairs and replacements; costs of utilities furnished to the Common Areas; sewer fees; cable television; trash collection; cleaning,
including windows; heating; ventilation; air-conditioning; maintenance of landscaping and grounds; maintenance of drives and parking areas; maintenance of the root security services and devices; building supplies; maintenance or replacement of
equipment utilized for operation and maintenance of the Project; license, permit and inspection fees; sales, use and excise taxes on goods and services purchased by Landlord in connection with the operation, maintenance or repair of the Project or
Building systems and equipment; telephone, postage, stationery supplies and other expenses incurred in connection with the operation, maintenance or repair of the Project; accounting, legal and other professional fees and expenses incurred in
connection with the Project; costs of furniture, draperies, carpeting, landscaping and other customary and ordinary items of personal property provided by Landlord for use in Common Areas or in the Building office; Building office rent or rental
value for a commercially reasonable amount of space, to the extent an office used for Building operations is maintained at the Building; capital expenditures; costs of complying with all federal, state, municipal and local laws, codes, ordinances,
rules and regulations of Governmental Authorities, committees, associations, or other regulatory committees, agencies or governing bodies having jurisdiction over the Property, the Project, the Building, the Premises, Landlord or Tenant, including
both statutory and common law and hazard waste rules and regulations (“Applicable Laws”); reasonable insurance premiums, including premiums for public liability, property casualty, earthquake, terrorism and environmental coverages;
portions of insured losses paid by Landlord as part of any commercially reasonable deductible portion of a loss pursuant to the terms of insurance policies; service contracts; costs of services of independent contractors retained to do work of a
nature referenced above; and costs of compensation (including employment taxes and fringe benefits) of all persons who perform regular and recurring 

  
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duties connected with the day-to-day operation and maintenance of the Project, its equipment, the adjacent walks, landscaped areas, drives and parking areas, including, without limitation,
janitors, floor waxers, window washers, watchmen, gardeners, sweepers and handymen. 
 Notwithstanding the foregoing, Operating
Expenses shall not include any leasing commissions; expenses that relate to preparation of rental space for a tenant; expenses of initial development and construction, including, but not limited to, initial costs of tools and equipment provided for
the initial commencement of operations, grading, paving, landscaping and decorating (as distinguished from maintenance, repair and replacement of the foregoing); legal expenses relating to other tenants; costs of repairs to the extent reimbursed by
payment of insurance proceeds received by Landlord; interest upon loans to Landlord or secured by a mortgage or deed of trust covering the Project or a portion thereof (provided that interest upon a government assessment or improvement bond
payable in installments shall constitute an Operating Expense under Subsection 8.1(a)); salaries of executive officers of Landlord; depreciation claimed by Landlord for tax purposes (provided that this exclusion of depreciation is
not intended to delete from Operating Expenses actual costs of repairs and replacements and reasonable reserves in regard thereto that are provided for in Subsection 8.1(b) and otherwise allowable under this Lease); and taxes of the
types that are excluded from Operating Expenses by the last sentence of Subsection 8.1(a); fees and costs, advertising and promotional expenses and other costs incurred in procuring tenants or in selling the Building or Project; legal
fees incurred in connection with approvals from and contract disputes with suppliers; costs of renovating or otherwise improving or decorating space for any tenant or other occupant of the Building or Project, including Tenant, or relocating any
tenant; financing costs including interest and principal amortization of debts and the costs of providing the same; rental on ground leases or other underlying leases and the costs of providing the same; wages, bonuses and other compensation of
employees above the grade of Building Manager; any liabilities, costs or expenses associated with or incurred in connection with the removal, enclosure, encapsulation of, and the cost of defending against claims in regard to the existence or release
of, Hazardous Substances or materials at the Building or Project which result from Landlord’s gross negligence or willful misconduct (except with respect to those costs for which Tenant is otherwise responsible pursuant to the express terms of
this Lease); costs of any items for which, and to the extent, Landlord is paid or reimbursed by insurance; increased insurance or Real Estate Taxes which are paid by any tenant of the Building or Project or for which Landlord is reimbursed from any
other tenant; charges for electricity, water, or other utilities, services or goods and applicable taxes for which Tenant or any other tenant, occupant, person or other party reimburses Landlord or pays to third parties; any violation of Applicable
Laws to the extent that such violation exists as of the Term Commencement Date; cost of any HVAC, janitorial or other services provided to tenants on an extra cost basis after regular business hours and for which such tenants reimburse Landlord;
cost of installing, operating and maintaining any specialty service, such as an observatory, broadcasting facilities, child or daycare, luncheon club or athletic or recreation club; any costs, expenses or fees associated with the initial
construction of the Building or Project; cost of any work or service performed on an extra cost basis for any tenant in the Building or Project to a materially greater extent or in a materially more favorable manner than furnished generally to the
tenants and other occupants; cost of any work or services performed for any facility other than the Building or Project; any cost representing an amount paid to a person, firm, corporation or other entity related to Landlord that is in excess of the

  
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amount which would have been paid in the absence of such relationship; any cost of painting or decorating any interior parts of the Building or Project other than Common Areas; any cost
associated with operating an on-or off-site management office for the Building or Development; Landlord’s general overhead and any other expense not directly attributable to operation and management of the Building and Project (e.g., the
activities of Landlord’s officers and executives or professional development expenditures); cost of initial cleaning and rubbish removal from the Building or Project to be performed before final completion of the base building or tenant space;
cost of initial landscaping of the Building or Project; attorneys’ fees, accounting fees and other expenditures incurred in connection with negotiations, disputes and claims of other tenants or occupants of the Building or Project; late fees or
charges incurred by Landlord due to late payment of expenses resulting from Landlord’s negligence or willful misconduct; cost of acquiring, securing, cleaning or maintaining sculptures, paintings and other works of art; taxes on Landlord’s
business (such as income, excess profits, franchise, capital stock, estate, inheritance, etc.); charitable or political contributions; costs and expenses incurred in connection with compliance with or the contesting or settlement of any claimed
violation of law or requirements of law; costs incurred because of any failure of the Project to comply with Applicable Laws, which failure exists as of the Term Commencment Date; direct costs or allocable costs associated with parking operations if
there is a separate charge to Tenant, other tenants or the public for parking; and all other items for which another party compensates or pays so that Landlord shall not recover any item of cost more than once. 

Furthermore, Operating Costs shall not include the cost of capital improvements (but shall include costs of capital repairs and
replacements), except for (A) the annual amortization (amortized over the lesser of ten (10) years or the useful life as reasonably determined by Landlord) of costs incurred by Landlord after the Commencement Date for any capital
improvements installed or paid for by Landlord and required by any laws, rules or regulations of any governmental or quasi-governmental authority due to a violation that does not exist on the Term Commencement Date of any such law, rule or
regulation; (B) the annual amortization (amortized over the lesser of ten (10) years or the useful life as reasonably determined by Landlord) of costs of any equipment, device or capital improvement purchased or incurred as a labor-saving
measure or to effect other economics in the operation or maintenance of the Building; or (C) minor capital improvements, tools or expenditures to the extent each such improvement or acquisition costs less than Fifty Thousand Dollars
($50,000.00). 
 Landlord shall at all times use commercially reasonable efforts to endeavor to operate the Building and Project
in an economically reasonable manner at costs not disproportionately higher than those experienced by other comparable buildings in the Seattle area. 
 8.2 Tenant shall pay to Landlord on the first day of each calendar month of the Term, as Additional Rent, (a) the Property Management Fee (as defined below) and (b) Landlord’s estimate of
Tenant’s Pro Rata Share of Operating Expenses with respect to the Building for such month. 

  
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 (x) The “Property Management Fee” shall equal three percent (3%) of
the Basic Annual Rent due from Tenant. 
 (y) Within ninety (90) days after the conclusion of each calendar year (or such
longer period as may be reasonably required by Landlord), Landlord shall furnish to Tenant a statement showing in reasonable detail the actual Operating Expenses and Tenant’s Pro Rata Share of Operating Expenses for the previous calendar year.
Any additional sum due from Tenant to Landlord shall be due and payable within thirty (30) days. If the amounts paid by Tenant pursuant to this Section 8.2 exceed Tenant’s Pro Rata Share of Operating Expenses for the previous
calendar year, then Landlord shall credit the difference against the Rent next due and owing from Tenant; provided that, if the Lease term has expired, Landlord shall accompany said statement with payment for the amount of such difference.

 (z) Any amount due under this Section 8.2 for any period that is less than a full month shall be prorated (based
on a thirty (30)-day month) for such fractional month. 
 8.3 Landlord’s annual statement shall be final and binding upon
Tenant unless Tenant, within ninety (90) days after Tenant’s receipt thereof, shall contest any item therein by giving written notice to Landlord, specifying each item contested and the reasons therefor. If, during such ninety (90)-day
period, Tenant reasonably and in good faith questions or contests the correctness of Landlord’s statement of Tenant’s Pro Rata Share of Operating Expenses, Landlord shall provide Tenant with reasonable access to review Landlord’s
books and records to the extent relevant to determination of Operating Expenses, and such information as Landlord reasonably determines to be responsive to Tenant’s written inquiries regarding the same. In the event that, after Tenant’s
review of such information, Landlord and Tenant (both acting in good faith) cannot agree upon the amount of Tenant’s Pro Rata Share of Operating Expenses, then Tenant shall have the right to have an independent public accounting firm hired by
Tenant on an hourly basis and not on a contingent-fee basis (at Tenant’s sole cost and expense except as provided below), subject to a reasonable confidentiality agreement and approved by Landlord (which approval Landlord shall not unreasonably
withhold or delay) audit and review such of Landlord’s books and records for the year in question as directly relate to the determination of Operating Expenses for such year (the “Independent Review”). Landlord shall make such
books and records available at the location where Landlord maintains them in the ordinary course of its business. Landlord need not provide copies of any books or records. Tenant shall commence the Independent Review within thirty (30) days
after the date Landlord has given Tenant access to Landlord’s books and records for the Independent Review. Tenant shall complete the Independent Review and notify Landlord in writing of Tenant’s specific objections to Landlord’s
calculation of Operating Expenses (including a written statement of the basis, nature and amount of each proposed adjustment) no later than ninety (90) days after Landlord has first given Tenant access to Landlord’s books and records for
the Independent Review. Landlord shall review the results of any such Independent Review. The parties shall endeavor in good faith to agree promptly and reasonably upon Operating Expenses taking into account the results of such Independent Review.
If, as of sixty (60) days after Tenant has submitted the Independent Review to Landlord, the parties have not agreed on the appropriate adjustments to Operating Expenses, then the parties shall engage a mutually agreeable independent

  
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third party accountant with at least ten (10) years’ experience in commercial real estate accounting in the Seattle, Washington area (the “Accountant”). If the parties
cannot agree on the Accountant, each shall within ten (10) days after such impasse appoint an Accountant (different from the accountant and accounting firm that conducted the Independent Review) and, within ten (10) days after the
appointment of both such Accountants, those two Accountants shall select a third (which cannot be the accountant and accounting firm that conducted the Independent Review). If either party fails to timely appoint an Accountant, then the Accountant
the other party appoints shall be the sole Accountant. Within ten (10) days after appointment of the Accountant(s), Landlord and Tenant shall each simultaneously give the Accountants (with a copy to the other party) its determination of
Operating Expenses, with such supporting data or information as each submitting party determines appropriate. Within ten (10) days after such submissions, the Accountants shall by majority vote select either Landlord’s or Tenant’s
determination of Operating Expenses. The Accountants may not select or designate any other determination of Operating Expenses. The determination of the Accountant(s) shall bind the parties. If the parties agree or the Accountant(s) determine that
Tenant’s Pro Rata Share of Operating Expenses actually paid for the calendar year in question exceeded Tenant’s obligations for such calendar year, then Landlord shall, at Tenant’s option, either (a) credit the excess to the next
succeeding installments of estimated Additional Rent or (b) pay the excess to Tenant within thirty (30) days after delivery of such results. If the parties agree or the Accountant(s) determine that Tenant’s payments of Tenant’s
Pro Rata Share of Operating Expenses for such calendar year were less than Tenant’s obligation for the calendar year, then Tenant shall pay the deficiency to Landlord within thirty (30) days after delivery of such results. If it is finally
agreed or determined that Landlord’s annual statement for any year overcharges Tenant by 5% or more, then Landlord shall reimburse Tenant all reasonable costs of such review (including without limitation the cost of third party auditors) within
thirty (30) days of Landlord’s receipt of an invoice therefor. 
 8.4 Tenant shall not be responsible for Operating
Expenses attributable to the time period prior to the Term Commencement Date; provided, however, that if Landlord shall permit Tenant possession of the Premises prior to the Term Commencement Date, Tenant shall be responsible for
Operating Expenses from such earlier date of possession. Tenant’s responsibility for Tenant’s Pro Rata Share of Operating Expenses shall continue to the latest of (a) the date of termination of the Lease, (b) the date Tenant has
fully vacated the Premises or (c) if termination of the Lease is due to a default by Tenant, the date of rental commencement of a replacement tenant. 
 8.5 Operating Expenses for the calendar year in which Tenant’s obligation to share therein commences and for the calendar year in which such obligation ceases shall be prorated on a basis reasonably
determined by Landlord. Expenses such as taxes, assessments and insurance premiums that are incurred for an extended time period shall be prorated based upon the time periods to which they apply so that the amounts attributed to the Premises relate
in a reasonable manner to the time period wherein Tenant has an obligation to share in Operating Expenses. 
 8.6 Within seven
(7) business days after the end of each calendar month, Tenant shall submit to Landlord an invoice, or, in the event an invoice is not available, an itemized list, of all costs and expenses that (a) Tenant has incurred (either internally
or by employing third parties) 

  
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during the prior month and (b) for which Tenant reasonably believes it is entitled to reimbursements from Landlord pursuant to the terms of this Lease or that Tenant reasonably believes is
the responsibility of Landlord pursuant to this Lease or the Work Letter. 
 9. Rentable Area. 

9.1 The term “Rentable Area” as set forth in Article 2 and as referenced within the Work Letter, and as may
otherwise be referenced within this Lease, shall reflect such areas as reasonably calculated by Landlord’s architect. 

9.2 The “Rentable Area” of the Building is generally determined by making separate calculations of Rentable Area
applicable to each floor within the Building and totaling the Rentable Area of all floors within the Building. The Rentable Area of a floor is computed by measuring to the outside finished surface of the permanent outer Building walls. The full area
calculated as previously set forth is included as Rentable Area, without deduction for columns and projections or vertical penetrations, including stairs, elevator shafts, flues, pipe shafts, vertical ducts and the like, as well as such items’
enclosing walls. Rentable Area throughout the Building shall be determined by Landlord via a consistent methodology. 
 9.3
Except as set forth in Section 9.6, the term “Rentable Area,” when applied to the Premises, is that area equal to the usable area of the Premises, plus an equitable allocation of Rentable Area within the Building that is not
then utilized or expected to be utilized as usable area, including, but not limited to, that portion of the Building devoted to corridors, equipment rooms, restrooms, elevator lobby, atrium and mailroom. In making such allocations, consideration
shall be given to tenants benefited by space allocated such that the area that primarily serves tenants of only one floor, such as corridors and restrooms upon such floor, shall be allocated to usable area of the Building, as a whole. Landlord shall
provide Tenant with a detailed summary of its calculation of the Premises Rentable Area. 
 9.4 Review of allocations of
Rentable Areas as between tenants of the Building and the Project shall be made as frequently as Landlord deems appropriate in order to facilitate an equitable apportionment of Operating Expenses. 

9.5 Final measurement of the Rentable Area of the Premises and the Building shall be determined by Landlord or Landlord’s architect
and confirmed by Tenant with respect to this Lease. To the extent that the actual Premises as finally measured are larger or smaller than the approximate Rentable Area set forth in Section 2.2 of this Lease, the Basic Annual Rent,
Tenant’s Pro Rata Share of the Building, the amount of the Security Deposit, the TI Allowance and Additional Allowance of the Premises (and such other variables in this Lease as are a function of Rentable Area) shall all be adjusted
accordingly. If Tenant notifies Landlord within fifteen (15) days after receiving the final determination of the Rentable Area and supporting documentation for the same that Tenant disagrees with the determination of the Rentable Area as
calculated by Landlord or Landlord’s architect, the matter shall be arbitrated by a single arbitrator in accordance with Commercial Arbitration Rules of the American Arbitration Association. The arbitrator’s decision shall be limited to
determining the square footage of the Rentable Area. The arbitrator shall have no 

  
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authority to make any other rulings or fashion any remedy. The decision of the arbitrator shall be final. The party losing the arbitration shall reimburse the prevailing party for all of the
prevailing party’s fees, costs and expenses of the arbitration, including attorneys’ fees and the arbitrator’s fees. 
 9.6 Landlord and Tenant intend to include the Storage Rooms within the Premises, but intend that Tenant will occupy the Storage Rooms without paying Basic Annual Rent for, or a share of Operating Expenses
allocated to, the Storage Rooms, and that the TI Allowance will be calculated without regard to the Storage Rooms. As such, the Storage Rooms shall be excluded from the Rentable Area of the Premises for purposes of determining the Basic Annual Rent,
Tenant’s Pro Rata Share of the Building and the amount of the TI Allowance, and the amounts set forth in Sections 2.2 and 2.3 have been calculated on that basis. 

10. Security Deposit. 
 10.1 Tenant shall deposit with Landlord within five (5) days of the Execution Date a security deposit in the amount set forth in Section 2.8 (the “Security Deposit”),
which Security Deposit shall be held by Landlord as security for the faithful performance by Tenant of all of the terms, covenants and conditions of this Lease to be kept and performed by Tenant during the period commencing on the Execution Date and
ending upon the expiration or termination of this Lease. If Tenant defaults with respect to any provision of this Lease, including, but not limited to, any provision relating to the payment of Rent, then Landlord may (but shall not be required to)
use, apply or retain all or any part of the Security Deposit for the payment of any Rent or any other sum in default, or to compensate Landlord for any other loss or damage that Landlord may suffer by reason of Tenant’s default. If any portion
of the Security Deposit is so used or applied, then Tenant shall, within ten (10) days following demand therefor, increase the amount of the L/C Security or deposit cash with Landlord in an amount sufficient to restore the Security Deposit to
its required amount, and Tenant’s failure to do so shall be a material breach of this Lease. The provisions of this Article 10 shall survive the expiration or earlier termination of this Lease. 

10.2 In the event of bankruptcy or other debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be applied
first to the payment of Rent and other charges due Landlord for all periods prior to the filing of such proceedings. 
 10.3
Landlord may deliver to any purchaser of Landlord’s interest in the Premises the funds deposited hereunder by Tenant, and thereupon Landlord shall be discharged from any further liability with respect to such deposit. This provision shall also
apply to any subsequent transfers. 
 10.4 If Tenant shall fully and faithfully perform every provision of this Lease to be
performed by it, then the Security Deposit, or any balance thereof, shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) days after the expiration or earlier
termination of this Lease. 

  
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 10.5 The Security Deposit may be in the form of cash, a letter of credit or any other
security instrument acceptable to Landlord in its sole discretion. Tenant may at any time, except during Default, deliver a letter of credit (the “L/C Security”) as the entire Security Deposit, as follows. 

(a) If Tenant elects to deliver L/C Security, then Tenant shall provide Landlord, and maintain in full force and effect throughout the
Term, a letter of credit in the form of Exhibit H issued by an issuer reasonably satisfactory to Landlord, in the amount of the Security Deposit, with an initial term of at least one year. If, at the Term Expiration Date, any Rent
remains uncalculated or unpaid, then: (i) Landlord shall with reasonable diligence complete any necessary calculations; and (ii) Tenant shall extend the expiry date of such L/C Security from time to time as Landlord reasonably requires
(not to exceed 30 days). Tenant shall reimburse Landlord’s reasonable legal costs (as reasonably estimated by Landlord’s counsel) in handling Landlord’s acceptance of L/C Security or its replacement or extension. 

(b) If Tenant delivers to Landlord satisfactory L/C Security in place of the entire Security Deposit, Landlord shall remit to Tenant any
cash Security Deposit Landlord previously held. 
 (c) Landlord may draw upon the L/C Security, and hold and apply the proceeds
in the same manner and for the same purposes as the Security Deposit, if: (i) an uncured Default exists; (ii) as of the date 45 days before any L/C Security expires (even if such scheduled expiry date is after the Term Expiration Date)
Tenant has not delivered to Landlord an amendment or replacement for such L/C Security, reasonably satisfactory to Landlord, extending the expiry date to the earlier of (1) six (6) months after the then-current Term Expiration Date or
(2) the date one year after the then-current expiry date of the L/C Security; (iii) the L/C Security provides for automatic renewals, Landlord requests that the issuer confirm the current L/C Security expiry date (with a copy of such
request to Tenant), and the issuer fails to do so within fifteen (15) business days after Tenant and the issuer each receives such request; (iv) Tenant fails to pay (when and as Landlord reasonably requires) any bank charges for
Landlord’s transfer of the L/C Security; or (v) the issuer of the L/C Security ceases, or announces that it will cease, to maintain an office in the city where Landlord may present drafts under the L/C Security. This paragraph does not
limit any other provisions of this Lease allowing Landlord to draw the L/C Security under specified circumstances. If Landlord draws on the Security L/C, any amount that is not applied in accordance with Section 10.1 hereof shall be held
as a cash Security Deposit. 
 (d) Tenant shall not seek to enjoin, prevent, or otherwise interfere with Landlord’s draw
under L/C Security, even if it violates this Lease. Landlord shall hold the proceeds of any draw in the same manner and for the same purposes as a cash Security Deposit. In the event of a wrongful draw, the parties shall cooperate to allow Tenant to
post replacement L/C Security simultaneously with the return to Tenant of the wrongfully drawn sums, and Landlord shall upon request confirm in writing to the issuer of the L/C Security that Landlord’s draw was erroneous. 

(e) If Landlord transfers its interest in the Premises, then Tenant shall at Tenant’s expense, within fifteen (15) business
days after receiving a request from Landlord, deliver (and, if the issuer requires, Landlord shall consent to) an amendment to the L/C Security naming Landlord’s grantee as substitute beneficiary. If the required Security changes while L/C
Security is in force, then Tenant shall deliver (and, if the issuer requires, Landlord shall consent to) a corresponding amendment to the L/C Security. 

  
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 11. Use. 
 11.1 Tenant shall use the Premises for the purpose set forth in Section 2.9, and shall not use the Premises, or permit or suffer the Premises to be used, for any other purpose without
Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion. 
 11.2 Tenant
shall not use or occupy the Premises in violation of Applicable Laws; zoning ordinances; or the certificate of occupancy issued for the Building, and shall, upon five (5) days’ written notice from Landlord, discontinue any use of the
Premises that is declared or claimed by any Governmental Authority having jurisdiction to be a violation of any of the above, or that in Landlord’s reasonable opinion violates any of the above. Tenant shall comply with any direction of any
Governmental Authority having jurisdiction that shall, by reason of the nature of Tenant’s use or occupancy of the Premises, impose any duty upon Tenant or Landlord with respect to the Premises or with respect to the use or occupation thereof.

 11.3 Tenant shall not do or permit to be done anything that will invalidate or increase (unless Tenant pays the increase for
the duration of the increase (even if after the end of the Term)) the cost of any fire, environmental, extended coverage or any other insurance policy covering the Building and the Project, and shall comply with all rules, orders, regulations and
requirements of the insurers of the Building and the Project, and Tenant shall promptly, upon demand, reimburse Landlord for any additional premium charged for such policy by reason of Tenant’s failure to comply with the provisions of this
Article. 
 11.4 Tenant shall keep all doors opening onto public corridors closed, except when in use for ingress and egress.

 11.5 No additional locks or bolts of any kind shall be placed upon any of the doors or windows by Tenant, nor shall any
changes be made to existing locks or the mechanisms thereof without Landlord’s prior written consent, which shall not be unreasonably withheld, conditioned or delayed. Tenant shall, upon termination of this Lease, return to Landlord all keys to
offices and restrooms either furnished to or otherwise procured by Tenant. In the event any key so furnished to Tenant is lost, Tenant shall pay to Landlord the cost of replacing the same or of changing the lock or locks opened by such lost key if
Landlord shall deem it necessary to make such change. 
 11.6 No awnings or other projections shall be attached to any outside
wall of the Building. No curtains, blinds, shades or screens shall be attached to or hung in, or used in connection with, any window or door of the Premises other than Landlord’s standard window coverings without Landlord’s prior written
consent, which consent shall not be unreasonably withheld, conditioned or delayed. Neither the interior nor exterior of any windows shall be coated or otherwise sunscreened without Landlord’s prior written consent, which shall not be
unreasonably withheld, conditioned or delayed. No equipment, furniture or other items of personal property shall be placed on any exterior balcony without Landlord’s prior written consent, which shall not be unreasonably withheld, conditioned
or delayed. 

  
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 11.7 No sign, advertisement or notice (“Signage”) shall be exhibited,
painted or affixed by Tenant on any part of the Premises or the Building without Landlord’s prior written consent, which shall not be unreasonably withheld, conditioned or delayed. Directory and suite entry identification for Tenant shall be
provided for Tenant by Landlord at Landlord’s sole cost and expense, and shall be of a size, color and type and be located in a place acceptable to Landlord. The directory tablet shall be provided exclusively for the display of the name and
location of tenants only. Tenant shall not place anything on the exterior of the corridor walls or corridor doors other than Landlord’s standard lettering without Landlord’s prior written consent, which shall not be unreasonably withheld,
conditioned or delayed. Tenant shall have Signage rights for the Premises substantially consistent with the Signage permitted for other comparable Tenants in the Project, as Landlord reasonably determines, including without limitation space on any
monument sign should one be constructed. At Landlord’s option, Landlord may install any such Signage, and Tenant shall pay all actual costs associated with such installation within thirty (30) days after demand therefor. 

11.8 Tenant shall use reasonable efforts consistent with a laboratory user to minimize the sounds or vibrations from equipment or
machinery installed by Tenant in the Premises that extend into the Common Areas or other offices in the Building. Further, Tenant shall only place equipment within the Premises with floor loading consistent with the structural design of the Building
(unless Tenant otherwise obtains Landlord’s prior written approval, which shall not be unreasonably withheld, conditioned or delayed) and such equipment shall be placed in a location designed to carry the weight of such equipment. 

11.9 Tenant shall not (a) do or permit anything to be done in or about the Premises that shall in any way unreasonably obstruct or
interfere with the rights of other tenants or occupants of the Building or the Project, or injure or annoy them, (b) use or allow the Premises to be used for immoral, unlawful or objectionable purposes, (c) cause, maintain or permit any
nuisance or waste in, on or about the Premises, the Building or the Project or (d) take any other action that would in Landlord’s reasonable determination in any manner materially adversely affect other tenants’ quiet use and
enjoyment of their space or adversely impact their ability to conduct business in a professional and suitable work environment. 

11.10 Notwithstanding any other provision herein to the contrary, but subject to Landlord’s obligations and warranties under this
Lease (including without limitation Section 4.3) Tenant shall be responsible for all liabilities, costs and expenses arising out of or in connection with the compliance of the Premises with the Americans with Disabilities Act, 42 U.S.C.
§ 12101, et seq. (together with regulations promulgated pursuant thereto, the “ADA”), and Tenant shall indemnify, defend and hold harmless Landlord from and against any loss, cost, liability or expense (including
reasonable attorneys’ fees and disbursements) arising out of any failure of the Premises to comply with the ADA. The provisions of this Section 11.10 shall survive the expiration or earlier termination of this Lease. 

  
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 12. Brokers. 

12.1 Tenant represents and warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation
of this Lease other than The Staubach Company (“Tenant’s Broker”), and that it knows of no other real estate broker or agent that is or might be entitled to a commission in connection with this Lease (other than Landlord’s
Broker, as set forth in Section 12.2 hereof). Landlord shall compensate Tenant’s Broker in relation to this Lease pursuant to a separate agreement between Landlord and Tenant’s Broker. 

12.2 Landlord represents and warrants that it has had no dealing with any real estate broker or agent in connection with the negotiation
of this Lease other than EDG Commercial Real Estate (“Landlord’s Broker”) and that it knows of no other real estate broker or agent that is or might be entitled to a commission in connection with this Lease (other than
Tenant’s Broker, as set forth in Section 12.1 hereof). Landlord shall compensate Landlord’s Broker in relation to this Lease pursuant to a separate agreement between Landlord and Landlord’s Broker. 

12.3 Tenant represents and warrants that no broker or agent has made any representation or warranty relied upon by Tenant in
Tenant’s decision to enter into this Lease, other than as contained in this Lease. 
 12.4 Tenant acknowledges and agrees
that the employment of brokers by Landlord is for the purpose of solicitation of offers of leases from prospective tenants and that no authority is granted to any broker to furnish any representation (written or oral) or warranty from Landlord
unless expressly contained within this Lease. Landlord is executing this Lease in reliance upon Tenant’s representations, warranties and agreements contained within Sections 12.1 and 12.3. 

12.5 Tenant agrees to indemnify, defend and hold Landlord harmless from any and all cost or liability for compensation claimed by any
other broker or agent, other than Tenant’s Broker, employed or engaged by it or claiming to have been employed or engaged by Tenant. Landlord agrees to indemnify, defend and hold Tenant harmless from any and all cost or liability for
compensation claimed by any other broker or agent, other than Landlord’s Broker, employed or engaged by it or claiming to have been employed or engaged by Landlord. 
 13. Holding Over. 
 13.1 If, with Landlord’s prior written consent,
Tenant holds possession of all or any part of the Premises after the Term, Tenant shall become a tenant from month to month after the expiration or earlier termination of the Term, and in such case Tenant shall continue to pay (a) the Basic
Annual Rent in accordance with Article 6, as adjusted in accordance with Article 7, and (b) Tenant’s Pro Rata Share of Operating Expenses. Any such month-to-month tenancy shall be subject to every other term,
covenant and agreement contained herein. 
 13.2 Notwithstanding the foregoing, if Tenant remains in possession of the Premises
after the expiration or earlier termination of the Term without Landlord’s prior written consent, Tenant shall become a tenant at sufferance subject to the terms and conditions of this Lease, except that the monthly rent shall be equal to one
hundred fifty percent (150%) of the Rent in effect during the last thirty (30) days of the Term. 

  
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 13.3 Acceptance by Landlord of Rent after the expiration or earlier termination of the Term
shall not result in an extension, renewal or reinstatement of this Lease. 
 13.4 The foregoing provisions of this
Article 13 are in addition to and do not affect Landlord’s right of reentry or any other rights of Landlord hereunder or as otherwise provided by Applicable Laws. 

14. Taxes on Tenant’s Property. 
 14.1 Tenant shall pay prior to delinquency any and all taxes levied against any personal property or trade fixtures placed by Tenant in or about the Premises. 

14.2 If any such taxes on Tenant’s personal property or trade fixtures are levied against Landlord or Landlord’s property or,
if the assessed valuation of the Building or the Property is increased by inclusion therein of a value attributable to Tenant’s personal property or trade fixtures, and if Landlord, after written notice to Tenant, pays the taxes based upon any
such increase in the assessed valued of the Building or the Project, then Tenant shall, upon demand, repay to Landlord the taxes so paid by Landlord. 
 14.3 If any improvements in or Alterations to the Premises, whether owned by Landlord or Tenant and whether or not affixed to the real property so as to become a part thereof, are assessed for real
property tax purposes at a valuation higher than the valuation at which improvements conforming to Landlord’s building standards (the “Building Standard”) in other spaces in the Building are assessed, then the real property
taxes and assessments levied against Landlord or the Building by reason of such excess assessed valuation shall be deemed to be taxes levied against personal property of Tenant and shall be governed by the provisions of Section 14.2
above. Any such excess assessed valuation due to improvements in or alterations to space in the Building leased by other tenants of Landlord shall not be included in the Operating Expenses defined in Article 8, but shall be treated, as
to such other tenants, as provided in this Section 14.3. If the records of the County Assessor are available and sufficiently detailed to serve as a basis for deteunining whether said Tenant improvements or alterations are assessed at a
higher valuation than the Building Standard, then such records shall be binding on both Landlord and Tenant. 
 15. Condition
of Premises. Tenant acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of the Premises, the Building or the Project, or with respect to the suitability of the
Premises, the Building or the Project for the conduct of Tenant’s business, except as otherwise set forth in this Lease. Tenant acknowledges that subject to Landlord’s representations, warranties and obligations set forth in this Lease
(a) it agrees to take the Premises in their condition “as is” as of the Temi Commencement Date, except as otherwise set forth in this Lease and (b) Landlord shall have no obligation to alter, repair or otherwise prepare the
Premises for Tenant’s occupancy or to pay for or construct any improvements to the Premises, except as otherwise set forth in this Lease. 

  
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 16. Common Areas and Parking Facilities. 

16.1 Tenant shall have the non-exclusive right, in common with others, to use the Common Areas, subject to the rules and regulations
adopted by Landlord and attached hereto as Exhibit D, together with such other reasonable and nondiscriminatory rules and regulations as are hereafter promulgated by Landlord in writing in its reasonable discretion (the “Rules
and Regulations”). Tenant shall faithfully observe and comply with the Rules and Regulations. Landlord shall not be responsible to Tenant for the violation or non-performance by any other tenant or any agent, employee or invitee thereof of
any of the Rules and Regulations. 
 16.2 Tenant shall be entitled to rent from Landlord on a monthly basis from time to time
throughout the Term an amount of parking spaces not to exceed one (1) parking space (located in the Building garage) per One Thousand rentable square feet of the Premises (“Tenant’s Parking Space Allowance”) on an
unreserved basis at a rate of One Hundred Seventy Five Dollars ($175.00) per parking space per month, which rate shall be subject to annual market-based increases not greater than three percent (3%) per calendar year. Notwithstanding the
foregoing, Landlord shall provide Tenant with Tenant’s Parking Space Allowance for the first twelve (12) months following the Rent Commencement Date at no cost to Tenant. 

16.3 Landlord reserves the right to modify the Common Areas, including the right to add or remove exterior and interior landscaping and
to subdivide real property, so long as such modifications do not materially adversely interfere with Tenant’s use and enjoyment of the Premises. Tenant acknowledges that Landlord specifically reserves the right to allow the exclusive use of
corridors and restroom facilities located on specific floors to one or more tenants occupying such floors; provided, however, that Tenant shall not be deprived of the use of the corridors reasonably required to serve the Premises or of
restroom facilities serving the floor upon which the Premises are located. 
 17. Utilities and Services. 

17.1 Tenant shall pay for all water (including the cost to service, repair and replace reverse osmosis, de-ionized and other treated
water), gas, heat, light, power, telephone, internet service, cable television, other telecommunications and other utilities supplied to the Premises together with any fees, surcharges and taxes thereon. If any such utility is not separately metered
to Tenant, Tenant shall pay a reasonable proportion (to be determined by Landlord) of all charges of such utility jointly metered with other premises as part of Tenant’s Pro Rata Share of Operating Expenses or, in the alternative, Landlord may,
at its option, monitor the usage of such utilities by Tenant and charge Tenant with the cost of purchasing, installing and monitoring such metering equipment, which cost shall be paid by Tenant as Additional Rent. 

17.2 Landlord shall not be liable for, nor shall any eviction of Tenant result from, the failure to furnish any utility or service,
whether or not such failure is caused by accident, breakage, repair, Force Majeure or Tenant’s negligence or gross negligence. Tenant shall provide written notice to Landlord of any interruption of a utility or service, and Landlord shall use
commercially reasonable efforts to correct any such interruption within five (5) business days after receipt of such notice. In the event that such failure continues for such five (5) business day period after Landlord’s receipt of
such written notice from Tenant, Tenant shall be entitled to a full 

  
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abatement of Rent during the period beginning at the end of such five (5) business day period for the duration of any such interruption to the extent that the same materially interferes with
Tenant’s use of the Premises and to the extent that the same is due to Landlord’s gross negligence or intentional misconduct. 
 17.3 Tenant shall pay for, prior to delinquency of payment therefor, any utilities and services that may be furnished to the Premises during or, if Tenant occupies the Premises after the expiration or
earlier termination of the Term, after the Term. 
 17.4 Tenant shall not, without Landlord’s prior written consent (which
shall not be unreasonably withheld, conditioned or delayed), use any device in the Premises (including, without limitation, data processing machines) that will in any way (a) increase the amount of ventilation, air exchange, gas, steam,
electricity or water beyond the existing capacity of the Building as proportionately allocated to the Premises based upon Tenant’s Pro Rata Share as usually furnished or supplied for the use set forth in Section 2.9 or
(b) exceed Tenant’s Pro Rata Share of the Building’s capacity to provide such utilities or services, unless Tenant installs additional equipment or installations with respect to such device that prevent any adverse effect on the
Building. 
 17.5 Tenant shall have the right to use the Building loading dock and freight elevator in common with other tenants
in the Building in a manner and with frequency proportionate to Tenant’s Pro Rata Share. 
 17.6 If Tenant shall require
utilities or services in excess of those usually furnished or supplied for tenants in similar spaces in the Building by reason of Tenant’s equipment or extended hours of business operations, then Tenant shall first procure Landlord’s
consent for the use thereof, which consent Landlord may reasonably condition upon the availability of such excess utilities or services, and Tenant shall pay as Additional Rent an amount equal to the cost of providing such excess utilities and
services. 
 17.7 Utilities and services provided by Landlord to the Premises that are separately metered shall be paid by
Tenant directly to the supplier of such utility or service if the same is practical; otherwise the same shall be paid to Landlord. 
 17.8 Landlord shall provide water in Common Areas for lavatory and water fountain purposes only. Tenant shall be entitled to use water in its Premises consistent with a laboratory user, and Landlord shall
install a water meter to measure Tenant’s water consumption for such purposes. Throughout the duration of Tenant’s occupancy of the Premises, Tenant shall keep said meter and installation equipment in good working order and repair at
Tenant’s sole cost and expense. If Tenant fails to so maintain such meter and equipment, Landlord may repair or replace the same and shall collect the costs therefor from Tenant. Tenant agrees to pay for water consumed, as shown on said meter,
as and when bills are rendered. If Tenant fails to timely make such payments, Landlord may pay such charges and collect the same from Tenant. Any such costs or expenses incurred, or payments made by Landlord for any of the reasons or purposes
hereinabove stated, shall be deemed to be Additional Rent payment by Tenant and collectible by Landlord as such. 

  
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 17.9 Landlord reserves the right to stop service of the elevator, plumbing, ventilation, air
conditioning and electric systems, when Landlord deems necessary or desirable, due to accident, emergency or the need to make repairs, alterations or improvements, until such repairs, alterations or improvements shall have been completed, and
Landlord shall further have no responsibility or liability for failure to supply elevator facilities, plumbing, ventilation, air conditioning or electric service when prevented from doing so by Force Majeure or a failure by a third party to deliver
gas, oil or another suitable fuel supply, or Landlord’s inability by exercise of reasonable diligence to obtain gas, oil or another suitable fuel; provided that Landlord shall use reasonable efforts to provide at least one (1) business day
advance written notice to Tenant (except in the event of an emergency) of any stop in service, repair, alteration or improvement that Landlord in good faith anticipates will materially and adversely impact Tenant, and Landlord further agrees to use
reasonable efforts to perform such work in a manner that keeps any disruption to Tenant to a reasonable level. Without limiting the foregoing, it is expressly understood and agreed that any covenants on Landlord’s part to furnish any service
pursuant to any of the terms, covenants, conditions, provisions or agreements of this Lease, or to perform any act or thing for the benefit of Tenant, shall not be deemed breached if Landlord is unable to furnish or perform the same by virtue of
Force Majeure. 
 18. Alterations. 
 18.1 Tenant shall make no alterations, additions or improvements in or to the Premises or engage in any construction, demolition, reconstruction, renovation, or other work (whether major or minor) of any
kind in, at, or serving the Premises (“Alterations”) without Landlord’s prior written approval, which approval Landlord shall not unreasonably withhold, condition or delay; provided, however, that in the event any
proposed Alteration adversely affects (a) any structural portions of the Building, including exterior walls, roof, foundation or core of the Building, (b) the exterior of the Building or (c) any Building systems, including elevator,
plumbing, air conditioning, heating, electrical, security, life safety and power, then Landlord may withhold its approval with respect thereto in its sole and absolute discretion. Tenant shall, in making any such Alterations, use only those
architects, contractors, suppliers and mechanics of which Landlord has given prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed. In seeking Landlord’s approval, Tenant shall provide Landlord, at
least fourteen (14) days in advance of any proposed construction, with plans, specifications, bid proposals, work contracts, requests for laydown areas and such other information concerning the nature and cost of the Alterations as Landlord may
reasonably request. Notwithstanding the foregoing, Tenant shall not be required to seek Landlord’s prior consent to cosmetic Alterations in the Premises that cost less than $50,000 in any one instance; provided, however, that in
the event any proposed Alteration adversely affects (a) any structural portions of the Building, including exterior walls, roof, foundation or core of the Building, (b) the exterior of the Building or (c) any Building systems,
including elevator, plumbing, air conditioning, heating, electrical, security, life safety and power, then Tenant must obtain Landlord’s approval, and Landlord may withhold such approval in its sole and absolute discretion. 

  
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 18.2 Tenant shall not construct or permit to be constructed partitions or other obstructions
that might interfere with free access to mechanical installation or service facilities of the Building, or interfere with the moving of Landlord’s equipment to or from the enclosures containing such installations or facilities, without first
obtaining Landlord’s approval, which shall not be unreasonably withheld, conditioned or delayed. 
 18.3 Tenant shall
accomplish any work performed on the Premises or the Building in such a manner as to permit any fire sprinkler system and fire water supply lines to remain fully operable at all times. 

18.4 Any work performed on the Premises or the Building by Tenant or Tenant’s contractors shall be done at such times and in such
manner as Landlord may from time to time reasonably designate. Tenant covenants and agrees that all work done by Tenant or Tenant’s contractors shall be performed in full compliance with Applicable Laws. Within thirty (30) days after
completion of any Alterations, if applicable, Tenant shall provide Landlord with complete “as-built” drawing print sets and electronic CADD files on disc (or files in such other current format in common use as Landlord reasonably approves
or requires) showing any changes in the Premises. Within sixty (60) days of the Term Commencement Date, Landlord shall provide Tenant with complete “as-built” drawing print sets and electronic CADD files on disc (or files in such
other current format in common use as Landlord reasonably approves or requires) for the Building, and agrees to provide Tenant with updates to the same to the extent necessary for Tenant to efficiently provide Landlord with the deliverables required
by the prior sentence. 
 18.5 All Tenant Improvements, Alterations, attached equipment, decorations, fixtures, trade fixtures,
additions and improvements, subject to Sections 18.8 and 20.3, attached to or built into the Premises, made by either of the Parties, including, without limitation, all floor and wall coverings, built-in cabinet work and paneling,
sinks and related plumbing fixtures, built-in laboratory benches, exterior venting fume hoods and walk-in freezers and refrigerators, ductwork, conduits, electrical panels and circuits (collectively, “Attached Property”), shall
(unless, prior to such construction or installation, Landlord elects otherwise in writing) become the property of Landlord upon the expiration or earlier termination of the Term, and shall remain upon and be surrendered with the Premises as a part
thereof. The Premises shall at all times remain the property of Landlord and shall be surrendered to Landlord upon the expiration or earlier termination of this Lease. Notwithstanding the foregoing, upon termination of this Lease, Tenant shall have
the right to remove any equipment, laboratory/research equipment, decorations, trade fixtures and personal property from the Premises that was paid for entirely by Tenant and that is not affixed to the Building or the Property in a manner that
removal of the same would require substantial alteration (for example, trade fixtures that are merely bolted to the Building would not require substantial alteration to remove; but an item such as an installed walk-in freezer would require
substantial alterations to remove) (“Tenant’s Personal Property”); provided, however, Tenant shall repair any damage to the Premises associated with such removal. 

18.6 Before commencing any work, Tenant shall give Landlord at least fourteen (14) days’ prior written notice of the proposed
commencement of such work and shall, if required by Landlord, secure, at Tenant’s own cost and expense, a completion and lien indemnity bond satisfactory to Landlord for said work. 

  
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 18.7 Tenant shall repair any damage to the Premises caused by Tenant’s removal of any
property from the Premises. During any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. The provisions of this Section shall survive the expiration or earlier
termination of this Lease. 
 18.8 If Tenant shall fail to remove any of its property from the Premises prior to termination of
this Lease, then Landlord may, at its option, remove the same in any manner that Landlord shall choose and store said effects without liability to Tenant for loss thereof or damage thereto, and Tenant shall pay Landlord, upon demand, any costs and
expenses incurred due to such removal and storage or Landlord may, at its sole option and without notice to Tenant, sell such property or any portion thereof at private sale and without legal process for such price as Landlord may obtain and apply
the proceeds of such sale against any (a) amounts due by Tenant to Landlord under this Lease and (b) any expenses incident to the removal, storage and sale of said personal property. 

18.9 Notwithstanding any other provision of this Article 18 to the contrary, in no event shall Tenant remove any improvement
from the Premises as to which Landlord contributed payment, including, without limitation, the Tenant Improvements made pursuant to the Work Letter without Landlord’s prior written consent, which consent Landlord may withhold in its sole and
absolute discretion. 
 18.10 Tenant shall reimburse Landlord for any extra expenses incurred by Landlord by reason of faulty
work done by Tenant or its contractors, or by reason of delays caused by such work, or by reason of inadequate clean-up. 

18.11 Within sixty (60) days after final completion of the Tenant Improvements (or any other Alterations performed by Tenant with
respect to the Premises), Tenant shall pay to Landlord an amount equal to four percent (4%) of the cost to Tenant of all Alterations installed by Tenant or its contractors or agents to cover Landlord’s overhead and expenses for plan
review, coordination, scheduling and supervision thereof (the “Alteration Fee”); provided, however, that no Alteration Fee shall be payable for any Alterations which do not require any plan review, coordination,
scheduling or supervision; and provided, further, that the parties agree that the Alteration Fee shall not apply to the Tenant Improvements since Landlord will receive the Construction Management Fee as described in the Work Letter.
For purposes of payment of such sum, Tenant shall submit to Landlord copies of all bills, invoices and statements covering the costs of such charges, accompanied by payment to Landlord of the fee set forth in this Section. Tenant shall reimburse
Landlord for any extra expenses incurred by Landlord by reason of faulty work done by Tenant or its contractors, or by reason of delays caused by such work, or by reason of inadequate clean-up. 

  
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 18.12 Tenant shall require its contractors and subcontractors performing work on the
Premises to name Landlord and its affiliates and lenders (so long as Landlord notifies Tenant in writing of the identity of the same) as additional insureds on their respective insurance policies. 

19. Repairs and Maintenance. 
 19.1 Landlord shall repair and maintain in good working condition the structural and exterior portions and Common Areas of the Building and the Project and all Building systems and utilities, including,
without limitation, roofing and covering materials, foundations, exterior walls, plumbing, fire sprinkler systems (if any), heating, ventilating, air conditioning, elevators, and electrical systems installed or furnished by Landlord. Any costs
related to the repair or maintenance activities specified in this Section 19.1 shall be included as a part of Operating Expenses to the extent allowable under Article 8, unless such repairs or maintenance is required in whole or in
part because of any act, neglect, fault or omissions of Tenant, its agents, servants, employees or invitees, in which case Tenant shall pay to Landlord the cost of such repairs and maintenance. 

19.2 Except for services of Landlord, if any, required by Section 19.1, Tenant shall at Tenant’s sole cost and expense
maintain and keep the Premises and every part thereof in good condition and repair, damage thereto from ordinary wear and tear excepted. Tenant shall, upon the expiration or sooner termination of the Term, surrender the Premises to Landlord in as
good of a condition as when received, ordinary wear and tear and casualty excepted. Landlord shall have no obligation to alter, remodel, improve, repair, decorate or paint the Premises or any part thereof, other than pursuant to the terms and
provisions of the Work Letter or this Lease. 
 19.3 Landlord shall not be liable for any failure to make any repairs or to
perform any maintenance that is an obligation of Landlord unless such failure shall persist for an unreasonable time after Tenant provides Landlord with written notice of the need of such repairs or maintenance. Tenant waives its rights under
Applicable Laws now or hereafter in effect to make repairs at Landlord’s expense. 
 19.4 Repairs under this
Article 19 that are obligations of Landlord are subject to allocation among Tenant and other tenants as Operating Expenses, except as otherwise provided in this Article 19. 

19.5 This Article 19 relates to repairs and maintenance arising in the ordinary course of operation of the Building and the
Project and any related facilities. In the event of fire, earthquake, flood, vandalism, war, terrorism, natural disaster or similar cause of damage or destruction, Article 23 shall apply in lieu of this Article 19.

 20. Liens. 
 20.1 Subject to the immediately succeeding sentence, Tenant shall keep the Premises, the Building and the Project free from any liens arising out of work performed, materials furnished or obligations
incurred by Tenant. Tenant further covenants and agrees that any mechanic’s lien filed against the Premises, the Building or the Project for work claimed to have been done for, or materials claimed to have been furnished to, shall be discharged
or bonded by Tenant within fifteen (15) days after the filing thereof, at Tenant’s sole cost and expense. 

  
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 20.2 Should Tenant fail to discharge or bond against any lien of the nature described in
Section 20.1, Landlord may, at Landlord’s election but following five (5) day’s prior written notice, pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title, and Tenant
shall immediately reimburse Landlord for the costs thereof as Additional Rent. 
 20.3 In the event that Tenant leases or
finances the acquisition of office equipment, furnishings, laboratory/research equipment, trade fixtures or other personal property utilized by Tenant in the operation of Tenant’s business (collectively, “Equipment”), Tenant
warrants that any Uniform Commercial Code financing statement executed by Tenant shall, upon its face or by exhibit thereto, indicate that such financing statement is applicable only to Equipment of Tenant located within the Premises. In no event
shall the address of the Building be furnished on a financing statement without qualifying language as to applicability of the lien only to Equipment located in an identified suite leased by Tenant. Should any holder of a financing statement
authorized by Tenant record or place of record a financing statement that appears to constitute a lien against any interest of Landlord in the real property or against equipment that may be located other than within an identified suite leased by
Tenant, Tenant shall, within ten (10) days after filing such financing statement, cause (a) a copy of the lender security agreement or other documents to which the financing statement pertains (subject to confidentiality requirements in
such agreement or other documents) to be furnished to Landlord to facilitate Landlord’s ability to demonstrate that the lien of such financing statement is not applicable to Landlord’s interest and (b) Tenant’s lender to amend
such financing statement and any other documents of record to clarify that any liens imposed thereby are not applicable to any interest of Landlord in the Premises, the Building or the Project. Notwithstanding anything to the contrary in this Lease,
all Tenant’s Personal Property and which may be moved without material damage to the Premises that is situated in or installed by Tenant in the Premises shall at all times remain Tenant’s property and Tenant may remove and replace any
Equipment at any time during the Term, provided that Tenant promptly repair any damage caused by the same. In no event shall Landlord have any common law or statutory lien or other security interest in any of Tenant’s Equipment, and Landlord
hereby expressly waives and releases any lien or security interest however created or arising. 
 21. Indemnification and
Exculpation. 
 21.1 Tenant agrees to indemnify, defend and save Landlord harmless from and against any and all demands,
claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all reasonable expenses (including, without limitation, reasonable attorneys’ fees, charges and disbursements) incurred in investigating or
resisting the same (collectively, “Claims”) arising from injury or death to any person or damage to any property occurring within or about the Premises, the Building or the Property arising directly or indirectly out of
Tenant’s or Tenant’s employees’, agents’ or guests’ use or occupancy of the Premises or a breach or default by Tenant in the performance of any of its obligations hereunder except to the extent

  
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caused by Landlord’s breach of Lease, willful misconduct or gross negligence. Subject to Section 21.2, Landlord agrees to indemnify, defend and save Tenant harmless from and
against any and all Claims arising from injury or death to any person or damage to any property occurring within or about the Premises, the Building or the Property to the extent that the same arise directly or indirectly out of the breach of Lease,
willful misconduct or gross negligence of Landlord or Landlord’s employees, agents or guests, except to the extent caused by Tenant’s breach of Lease, willful misconduct or negligence. 

21.2 Notwithstanding any provision of Section 21.1 to the contrary, Landlord shall not be liable to Tenant for, and Tenant
assumes all risk of, damage to personal property or scientific research, including, without limitation, loss of records kept by Tenant within the Premises and damage or losses caused by fire, electrical malfunction, gas explosion or water damage of
any type (including, without limitation, broken water lines, malfunctioning fire sprinkler systems, roof leaks or stoppages of lines), except to the extent that any such loss is due to Landlord’s gross negligence or willful disregard of written
notice by Tenant of need for a repair that Landlord is responsible to make for an unreasonable period of time. Tenant further waives any claim for injury to its business or loss of income relating to any such damage or destruction of personal
property as described in this Section 21.2. 
 21.3 Landlord shall not be liable for any damages arising from any
act, omission or neglect of any other tenant in the Building or the Project, or of any other third party. 
 21.4 Tenant
acknowledges that security devices and services, if any, while intended to deter crime, may not in given instances prevent theft or other criminal acts. Landlord shall not be liable for injuries or losses caused by criminal acts of third parties,
and Tenant assumes the risk that any security device or service may malfunction or otherwise be circumvented by a criminal. If Tenant desires protection against such criminal acts, then Tenant shall, at Tenant’s sole cost and expense, obtain
appropriate insurance coverage. 
 21.5 The provisions of this Article 21 shall survive the expiration or earlier
termination of this Lease. 
 21.6 The indemnity from Tenant in this Article 21 is intended to specifically cover actions
brought by Tenant’s own employees, with respect to acts or omissions during the term of this Lease. In that regard, with respect to Landlord, Tenant waives any immunity it may have under Washington’s Industrial Insurance Act, RCW
Title 51, to the extent necessary to provide Landlord with a full and complete indemnity from claims made by Tenant and its employees, to the extent of their negligence. If losses, liabilities, damages, liens, costs and expenses covered by
Tenant’s indemnity are caused by the sole negligence Landlord or by the concurrent negligence of both Landlord and Tenant, or their respective employees, agents, invitees and licensees, then Tenant shall indemnify Landlord only to the extent of
Tenant’s own negligence or that of its officers, agents, employees, guests or invitees. LANDLORD AND TENANT ACKNOWLEDGE THAT THE INDEMNIFICATION PROVISIONS OF THIS ARTICLE 21 WERE SPECIFICALLY NEGOTIATED AND AGREED UPON BY THEM.

  
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 22. Insurance; Waiver of Subrogation. 

22.1 Landlord shall maintain insurance for the Building and the Project, including the Tenant Improvements, in amounts equal to full
replacement cost (exclusive of the costs of excavation, foundations and footings, and without reference to depreciation taken by Landlord upon its books or tax returns) or such lesser coverage as Landlord may elect, provided that the
deductibles for such insurance coverage shall be commercially reasonable; and provided further that the limits of such coverage shall not be less than ninety percent (90%) of such full replacement cost or the amount of such
insurance Landlord’s lender, mortgagee or beneficiary (each, a “Lender”), if any, requires Landlord to maintain, providing protection against any peril generally included within Special Form property insurance. Landlord,
subject to availability thereof, shall further insure, if Landlord deems it appropriate, coverage against flood, environmental hazard, earthquake, loss or failure of building equipment, rental loss during the period of repairs or rebuilding,
workmen’s compensation insurance and fidelity bonds for employees employed to perform services. Notwithstanding the foregoing, Landlord may, but shall not be deemed required to, provide insurance for any improvements installed by Tenant or that
are in addition to the Tenant Improvements, without regard to whether or not such are made a part of or are affixed to the Building. Any costs incurred by Landlord pursuant to this Section 22.1 shall constitute a portion of Operating
Expenses. 
 22.2 In addition, Landlord shall carry commercial general liability insurance with a single limit of not less than
One Million Dollars ($1,000,000) for death or bodily injury, or property damage with respect to the Project. Any costs incurred by Landlord pursuant to this Section 22.2 shall constitute a portion of Operating Expenses. 

22.3 Tenant shall, at its own cost and expense, procure and maintain in effect, beginning on the Term Commencement Date or the date of
occupancy, whichever occurs first, and continuing throughout the Term (and occupancy by Tenant, if any, after termination of this Lease) commercial general liability insurance with limits of not less than One Million Dollars ($1,000,000) per
occurrence and Two Million Dollars ($2,000,0000) general aggregate for death or bodily injury and property damage with respect to the Premises (including $100,000 fire legal liability (each loss)). 

22.4 The liability insurance required to be purchased and maintained by Tenant pursuant to this Lease shall name Landlord, BioMed Realty,
L.P., BioMed Realty Trust, Inc., Landlord’s constituent partners and the Building Lenders (if disclosed by Landlord to Tenant in writing) (“Landlord Parties”) as additional insureds. All insurance carried by either Landlord or
Tenant as required under this Lease shall be with companies having a rating of not less than policyholder rating of A- and financial category rating of at least Class VII in “Best’s Insurance Guide.” Tenant shall obtain for Landlord
from the insurance companies or cause the insurance companies to furnish certificates of coverage to Landlord. No such policy shall be cancelable or subject to reduction of coverage or other modification or cancellation except after thirty
(30) days’ prior written notice to Landlord from the insurer (except in the event of non-payment of premium, in which case ten (10) days written notice shall be given). All such policies shall be written as primary

  
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policies, not contributing with and not in excess of the coverage that Landlord may carry. Tenant’s policy may be a “blanket policy” that specifically provides that the amount of
insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, prior to the expiration of such policies, furnish Landlord with renewals or binders. Tenant agrees that if Tenant does not take out and maintain such insurance,
Landlord may (but shall not be required to) procure said insurance on Tenant’s behalf and at its cost to be paid by Tenant as Additional Rent. 
 22.5 Tenant assumes the risk of damage to any fixtures, goods, inventory, merchandise, equipment and leasehold improvements, and Landlord shall not be liable for injury to Tenant’s business or any
loss of income therefrom, relative to such damage, all as more particularly set forth within this Lease. Tenant shall, at Tenant’s sole cost and expense, carry such insurance as Tenant desires for Tenant’s protection with respect to
personal property of Tenant or business interruption. 
 22.6 In each instance where insurance is to name Landlord Parties as
additional insureds, Tenant shall, upon Landlord’s written request, also designate and furnish certificates evidencing such Landlord Parties as additional insureds to (a) any Lender of Landlord holding a security interest in the Building
or the Project, (b) the landlord under any lease whereunder Landlord is a tenant of the real property upon which the Building is located if the interest of Landlord is or shall become that of a tenant under a ground lease rather than that of a
fee owner, and (c) any management company retained by Landlord to manage the Project. 
 22.7 Landlord and Tenant each
hereby waive any and all rights of recovery against the other or against the officers, directors, employees, agents and representatives of the other on account of loss or damage occasioned by such waiving party or its property or the property of
others under such waiving party’s control, in each case to the extent that such loss or damage is insured against under any Special Form insurance policy that either Landlord or Tenant may have in force at the time of such loss or damage or are
required to carry by this Lease, whichever is greater. Landlord and Tenant, upon obtaining the policies of insurance required or permitted under this Lease, shall give notice to the insurance carrier or carriers that the foregoing mutual waiver of
subrogation is contained in this Lease. If the release of either Landlord or Tenant, as set forth in the first sentence of this Section 22.7, shall contravene Applicable Laws, then the liability of the party in question shall be deemed
not released but shall be secondary to the other party’s insurer. 
 22.8 Landlord may require insurance policy limits
required under this Lease to be raised to conform with reasonable requirements of Landlord’s Lender or, following the initial Term, to bring coverage limits to levels then being required of new tenants within the Project. 

23. Damage or Destruction. 
 23.1 In the event of a partial destruction of the Building or the Project by fire or other perils covered by extended coverage insurance not exceeding twenty-five percent (25%) of the full insurable
value thereof, and provided that (a) the damage thereto is such that the Building or the Project may be repaired, reconstructed or restored within a period of twelve (12) months from the date of the happening of such casualty and
(b) Landlord shall receive insurance proceeds sufficient 

  
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to cover the cost of such repairs (except for any deductible amount provided by Landlord’s policy, which deductible amount, if paid by Landlord, shall constitute an Operating Expense),
Landlord shall commence and proceed diligently with the work of repair, reconstruction and restoration of the Building or the Project, as applicable, and this Lease shall continue in full force and effect. 

23.2 In the event of any damage to or destruction of the Building or the Project other than as described in Section 23.1,
Landlord may elect to repair, reconstruct and restore the Building or the Project, as applicable, in which case this Lease shall continue in full force and effect. If Landlord elects not to repair the Building or the Project, as applicable, then
this Lease shall terminate as of the date of such damage or destruction. 
 23.3 Landlord shall give written notice to Tenant
within sixty (60) days following the date of damage or destruction of its election whether to repair, reconstruct or restore the Building or the Project, as applicable, and in such notice, Landlord shall indicate Landlord’s good faith
estimate of the time to complete such repairs. If the expected time to complete repairs exceeds twelve (12) months, then Tenant may terminate this Lease upon written notice given to Landlord within thirty (30) days after receipt of
Landlord’s notice. 
 23.4 Upon any termination of this Lease under any of the provisions of this Article 23,
the parties shall be released thereby without further obligation to the other from the date possession of the Premises is surrendered to Landlord, except with regard to (a) items occurring prior to the damage or destruction and
(b) provisions of this Lease that, by their express terms, survive the expiration or earlier termination hereof. All property insurance proceeds (except with respect to Tenant’s personal property and removable equipment that Tenant
purchased without any contribution from Landlord) shall be paid to Landlord. 
 23.5 In the event of repair, reconstruction and
restoration as provided in this Article 23, all Rent to be paid by Tenant under this Lease shall be abated proportionately based on the extent to which Tenant’s use of the Premises is impaired during the period of such repair,
reconstruction or restoration, unless Landlord at its sole cost provides Tenant with other space during the period of repair that, in Tenant’s reasonable opinion, is suitable for the temporary conduct of Tenant’s business; provided,
however, that the amount of such abatement shall be reduced by the proceeds of business interruption insurance actually received by Tenant with respect to the Premises. 
 23.6 Notwithstanding anything to the contrary contained in this Article 23, should Landlord be delayed or prevented from completing the repair, reconstruction or restoration of the damage or
destruction to the Premises after the occurrence of such damage or destruction by Force Majeure, then the time for Landlord to commence or complete repairs shall be extended on a day-for-day basis. 

23.7 If Landlord is obligated to or elects to repair, reconstruct or restore as herein provided, then Landlord shall be obligated to make
such repair, reconstruction or restoration only with regard to those portions of the Premises, the Building or the Property that were originally provided at Landlord’s expense. The repair, reconstruction or restoration of improvements not
originally provided by Landlord or at Landlord’s expense shall be the obligation of Tenant. In the 

  
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event Tenant has elected to upgrade certain improvements from the Building Standard, Landlord shall, upon the need for replacement due to an insured loss, provide only the Building Standard
(except with respect to improvements paid for out of the TI Allowance), unless Tenant again elects to upgrade such improvements and pay any incremental costs related thereto, except to the extent that excess insurance proceeds, if received, are
adequate to provide such upgrades, in addition to providing for basic repair, reconstruction and restoration of the Premises, the Building and the Project. 
 23.8 Notwithstanding anything to the contrary contained in this Article 23, Landlord shall not have any obligation whatsoever to repair, reconstruct or restore the Premises if the damage
resulting from any casualty covered under this Article 23 occurs during the last twelve (12) months of the Term or any extension hereof, or to the extent that insurance proceeds are not available therefor (provided Landlord carried
insurance required under this Lease). Furthermore, if the damage resulting from any casualty covered under this Article 23 occurs during the last twelve (12) months of the Term or any extension hereof, Tenant shall be entitled to
terminate this Lease upon written notice to Landlord. 
 23.9 Landlord’s obligation, should it elect or be obligated to
repair or rebuild, shall be limited to the Property and the Building; provided that Tenant shall, at its expense, replace or fully repair all of Tenant’s personal property and any Alterations installed by Tenant existing at the time of
such damage or destruction. If the Property or the Building is to be repaired in accordance with the foregoing, Landlord shall make available to Tenant any portion of insurance proceeds it receives that are allocable to the Alterations constructed
by Tenant pursuant to this Lease, provided Tenant is not then in default beyond applicable notice and cure periods under this Lease. 
 24. Eminent Domain. 
 24.1 In the event the whole of the Premises, or such
part thereof as shall substantially interfere with Tenant’s use and occupancy thereof, shall be taken for any public or quasi-public purpose by any lawful power or authority by exercise of the right of appropriation, condemnation or eminent
domain, or sold to prevent such taking, Tenant or Landlord may terminate this Lease effective as of the date possession is required to be surrendered to said authority. 
 24.2 In the event of a partial taking of the Building or the Project, or of drives, walkways or parking areas serving the Building or the Project for any public or quasi-public purpose by any lawful power
or authority by exercise of right of appropriation, condemnation, or eminent domain, or sold to prevent such taking, then, without regard to whether any portion of the Premises occupied by Tenant was so taken, Landlord may elect to terminate this
Lease as of such taking if such taking is, in Landlord’s reasonable opinion, of a material nature such as to make it uneconomical to continue use of the unappropriated portion for purposes of renting office or laboratory space. 

24.3 Tenant shall be entitled to any award that is specifically awarded as compensation for (a) the taking of Tenant’s personal
property that was installed solely at Tenant’s expense and (b) the costs of Tenant moving to a new location. Except as set forth in the previous sentence, any award for such taking shall be the property of Landlord. 

  
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 24.4 If, upon any taking of the nature described in this Article 24, this Lease
continues in effect, then Landlord shall promptly proceed to restore the Premises, the Building and the Project, as applicable, to substantially their same condition prior to such partial taking to the extent such restoration is feasible, as
determined by Landlord in its sole and absolute discretion. The Rent shall be decreased proportionately to reflect the loss of any portion of the Premises no longer available to Tenant. 

25. Defaults and Remedies. 
 25.1 Late payment by Tenant to Landlord of Rent and other sums due shall cause Landlord to incur costs not contemplated by this Lease, the exact amount of which shall be extremely difficult and
impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges that may be imposed on Landlord by the terms of any mortgage or trust deed covering the Premises. Therefore, if any
installment of Rent due from Tenant is not received by Landlord within three (3) business days after Tenant’s receipt of written notice from Landlord regarding such overdue amount (provided that Tenant shall only be entitled to one
(1) such written notice in a consecutive twelve (12) month period), Tenant shall pay to Landlord an additional sum of five percent (5%) of the overdue Rent as a late charge. The parties agree that this late charge represents a fair
and reasonable estimate of the costs that Landlord shall incur by reason of late payment by Tenant. 
 25.2 No payment by Tenant
or receipt by Landlord of a lesser amount than the Rent payment herein stipulated shall be deemed to be other than on account of the Rent, nor shall any endorsement or statement on any check or any letter accompanying any check or payment as Rent be
deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or pursue any other remedy provided in this Lease or in equity or at law. If a dispute
shall arise as to any amount or sum of money to be paid by Tenant to Landlord hereunder, Tenant shall have the right to make payment “under protest,” such payment shall not be regarded as a voluntary payment, and there shall survive the
right on the part of Tenant to institute suit for recovery of the payment paid under protest. 
 25.3 If Tenant fails to pay any
sum of money required to be paid by it hereunder, or shall fail to perform any other act on its part to be performed hereunder, Landlord may, without waiving or releasing Tenant from any obligations of Tenant, but shall not be obligated to, make
such payment or perform such act; provided that such failure by Tenant continues for three (3) days after Landlord delivers notice to Tenant demanding performance by Tenant; or provided that such failure by Tenant unreasonably
interfered with the use of the Building by any other tenant or with the efficient operation of the Building, or resulted or could have resulted in a violation of Applicable Laws or the cancellation of an insurance policy maintained by Landlord.
Notwithstanding the foregoing, in the event of an emergency, Landlord shall have the right to enter the Premises and act in accordance with its rights as provided elsewhere in this Lease. In addition to the late charge described in
Section 25.1, Tenant shall pay to Landlord as Additional Rent all sums so paid or 

  
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incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal to twelve percent (12%) per annum or the highest rate permitted
by Applicable Laws, whichever is less. 
 25.4 The occurrence of any one or more of the following events shall constitute a
“Default” hereunder by Tenant: 
 (a) The vacation of the Premises by Tenant without the intention to continue
to perform obligations; 
 (b) The failure by Tenant to make any payment of Rent, as and when due, where such failure shall
continue for a period of three (3) business days after Tenant’s receipt of written notice thereof from Landlord; 

(c) The failure by Tenant to observe or perform any obligation or covenant contained herein (other than described in
Subsection 25.4(a)) to be performed by Tenant, where such failure shall continue for a period of thirty (30) days after written notice thereof from Landlord to Tenant; provided that, if the nature of Tenant’s default is
such that it reasonably requires more than thirty (30) days to cure, Tenant shall not be deemed to be in default if Tenant shall commence such cure within said thirty (30) day period and thereafter diligently prosecute the same to
completion; 
 (d) Tenant makes an assignment for the benefit of creditors; 

(e) A receiver, trustee or custodian is appointed to or does take title, possession or control of all or substantially all of
Tenant’s assets; 
 (f) Tenant files a voluntary petition under the United States Bankruptcy Code or any successor statute
(the “Bankruptcy Code”); 
 (g) Any involuntary petition if filed against Tenant under any chapter of the
Bankruptcy Code and is not dismissed within one hundred twenty (120) days; 
 (h) The failure by Tenant to deliver an
estoppel certificate in accordance with Article 30 where such failure shall continue for a period of three (3) business days after Tenant’s receipt of written notice thereof from Landlord; 

(i) The failure by Tenant to subordinate its interest under this Lease in accordance with Section 35.3 hereof where such
failure shall continue for a period of three (3) business days after Tenant’s receipt of written notice thereof from Landlord; and 
 (j) Tenant’s interest in this Lease is attached, executed upon or otherwise judicially seized and such action is not released within one hundred twenty (120) days of the action. 

  
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 Notices given under this Section 25.4 shall specify the alleged default and
shall demand that Tenant perform the provisions of this Lease or pay the Rent that is in arrears, as the case may be, within the applicable period of time, or quit the Premises. No such notice shall be deemed a forfeiture or a termination of this
Lease unless Landlord elects otherwise in such notice. The foregoing notice and cure provisions shall be inclusive of and not in addition to the notices and cure periods provided for in RCW 59.12, as now or hereafter amended, or any legislation in
lieu or substitution thereof. 
 25.5 In the event of a Default by Tenant, and at any time thereafter, with or without notice or
demand and without limiting Landlord in the exercise of any right or remedy that Landlord may have, Landlord shall be entitled to terminate Tenant’s right to possession of the Premises by any lawful means, in which case this Lease shall
terminate and Tenant shall immediately surrender possession of the Premises to Landlord. In such event, Landlord shall have the immediate right to re-enter and remove all persons and property, and such property may be removed and stored in a public
warehouse or elsewhere at the cost and for the account of Tenant, all without service of notice or resort to legal process and without being deemed guilty of trespass or becoming liable for any loss or damage that may be occasioned thereby, except
to the extent of Landlord’s gross negligence or intentional misconduct. In the event that Landlord shall elect to so terminate this Lease, then Landlord shall be entitled to recover from Tenant all damages incurred by Landlord by reason of
Tenant’s default, including, without limitation: 
 (a) The worth at the time of award of any unpaid Rent that had accrued
at the time of such termination; plus 
 (b) The worth at the time of award of the amount by which the unpaid Rent that would
have accrued during the period commencing with termination of the Lease and ending at the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord’s reasonable satisfaction
could have been reasonably avoided; plus 
 (c) The worth at the time of award of the amount by which the unpaid Rent for the
balance of the Term after the time of award exceeds that portion of the loss of Landlord’s rental income from the Premises that Tenant proves to Landlord’s reasonable satisfaction could have been reasonably avoided; plus 

(d) Any other amount necessary to compensate Landlord for all the detriment caused by Tenant’s failure to perform its obligations
under this Lease or that in the ordinary course of things would be likely to result therefrom, including, without limitation, the cost of restoring the Premises to the condition required under the terms of this Lease; plus 

(e) At Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by
Applicable Laws. 
 As used in Subsections 25.5(a) and 25.5(b), “worth at the time of award” shall be computed by
allowing interest at the rate specified in Section 25.1. As used in Subsection 25.5(c) above, the 

  
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“worth at the time of the award” shall be computed by taking the present value of such amount, using the discount rate of the Federal Reserve Bank of San Francisco at the time of the
award plus one (1) percentage point. 
 25.6 In addition to any other remedies available to Landlord at law or in equity
and under this Lease, Landlord may continue this Lease in effect after Tenant’s Default and abandonment and recover Rent as it becomes due, provided Tenant has the right to sublet or assign, subject only to reasonable limitations). In
addition, Landlord shall not be liable in any way whatsoever for its failure or refusal to relet the Premises. For purposes of this Section 25.6, the following acts by Landlord will not constitute the termination of Tenant’s right
to possession of the Premises: 
 (a) Acts of maintenance or preservation or efforts to relet the Premises, including, but not
limited to, alterations, remodeling, redecorating, repairs, replacements or painting as Landlord shall consider advisable for the purpose of reletting the Premises or any part thereof; or 

(b) The appointment of a receiver upon the initiative of Landlord to protect Landlord’s interest under this Lease or in the
Premises. 
 Notwithstanding the foregoing, in the event of a Default by Tenant, Landlord may elect at any time to terminate this Lease and to
recover damages to which Landlord is entitled. If Landlord does not elect to terminate this Lease as provided in Section 25.5, then Landlord may, from time to time, recover all Rent as it becomes due under this Lease. 

25.7 In the event Landlord elects to terminate this Lease and relet the Premises, Landlord may execute any new lease in its own name.
Tenant hereunder shall have no right or authority whatsoever to collect any Rent from such tenant. The proceeds of any such reletting shall be applied as follows: 
 (a) First, to the payment of any indebtedness other than Rent due hereunder from Tenant to Landlord, including, without limitation, storage charges or brokerage commissions owing from Tenant to Landlord
as the result of such reletting; 
 (b) Second, to the payment of the costs and expenses of reletting the Premises, including
(i) alterations and repairs that Landlord deems reasonably necessary and advisable and (ii) reasonable attorneys’ fees, charges and disbursements incurred by Landlord in connection with the retaking of the Premises and such reletting;

 (c) Third, to the payment of Rent and other charges due and unpaid hereunder; and 

(d) Fourth, to the payment of future Rent and other damages payable by Tenant under this Lease. 

  
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 25.8 All of Landlord’s rights, options and remedies hereunder shall be construed and
held to be nonexclusive and cumulative. Landlord shall have the right to pursue any one or all of such remedies, or any other remedy or relief that may be provided by Applicable Laws, whether or not stated in this Lease. No waiver of any default of
Tenant hereunder shall be implied from any acceptance by Landlord of any Rent or other payments due hereunder or any omission by Landlord to take any action on account of such default if such default persists or is repeated, and no express waiver
shall affect defaults other than as specified in said waiver. 
 25.9 Landlord’s termination of (a) this Lease or
(b) Tenant’s right to possession of the Premises shall not relieve Tenant of any liability to Landlord that has previously accrued or that shall arise based upon events that occurred prior to the later to occur of (i) the date of
Lease termination or (ii) the date Tenant surrenders possession of the Premises. 
 25.10 To the extent permitted by
Applicable Laws, Tenant waives any and all rights of redemption granted by or under any present or future Applicable Laws if Tenant is evicted or dispossessed for any cause, or if Landlord obtains possession of the Premises due to Tenant’s
default hereunder or otherwise. 
 25.11 Landlord shall not be in default under this Lease unless Landlord fails to perform
obligations required of Landlord within a reasonable time, but in no event shall such failure continue for more than thirty (30) days after written notice from Tenant specifying the nature of Landlord’s failure; provided,
however, that if the nature of Landlord’s obligation is such that more than thirty (30) days are required for its performance, then Landlord shall not be in default if Landlord commences performance within such thirty (30) day
period and thereafter diligently prosecutes the same to completion. 
 25.12 In the event of any default by Landlord, Tenant
shall give notice by registered or certified mail to any (a) beneficiary of a deed of trust or (b) mortgagee under a mortgage covering the Premises, the Building or the Project and to any landlord of any lease of land upon or within which
the Premises, the Building or the Project is located, and shall offer such beneficiary, mortgagee or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Building by power of sale or a judicial action if
such should prove necessary to effect a cure; provided that Landlord shall furnish to Tenant in writing the names and addresses of all such persons who are to receive such notices. 

26. Assignment or Subletting. 
 26.1 Except as hereinafter expressly permitted, Tenant shall not, either voluntarily or by operation of Applicable Laws, directly or indirectly sell, hypothecate, assign, pledge, encumber or otherwise
transfer this Lease, or sublet the Premises (each, a “Transfer”), without Landlord’s prior written consent, which consent Landlord may not unreasonably withhold, condition or delay. Tenant shall have the right to Transfer
without Landlord’s prior written consent the Lease or any portion thereof or the Premises or any part thereof to any person or entity that as of the date of determination and at all times thereafter directly, or indirectly through one or more
intermediaries, controls, is controlled by, or is under common control with Tenant, to any entity resulting from the 

  
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merger, consolidation, acquisition or restructuring of Tenant, or to the purchaser in connection with the sale of substantially all of the assets used in connection with the business operated by
Tenant at the Building (“Tenant’s Affiliate”), provided Tenant shall notify Landlord in writing at least thirty (30) days prior to the effectiveness of such Transfer to Tenant’s Affiliate (an “Exempt
Transfer”) and otherwise comply with the requirements of this Lease regarding such Transfer. For purposes of Exempt Transfers, “control” requires both (a) owning (directly or indirectly) more than fifty percent (50%) of
the stock or other equity interests of another person and (b) possessing, directly or indirectly, the power to direct or cause the direction of the management and policies of such person. Notwithstanding anything to the contrary, the following
Sections 26.2, 26.3 and 26.9 of the Lease shall not be applicable to any Exempt Transfer. 
 26.2 In
the event Tenant desires to effect a Transfer, then, at least forty-five (45) but not more than ninety (90) days prior to the date when Tenant desires the assignment or sublease to be effective (the “Transfer Date”),
Tenant shall provide written notice to Landlord (the “Transfer Notice”) containing information (including references) concerning the character of the proposed transferee, assignee or sublessee; the Transfer Date; any ownership or
commercial relationship between Tenant and the proposed transferee, assignee or sublessee; and the consideration and all other material terms and conditions of the proposed Transfer, all in such detail as Landlord shall reasonably require. Tenant
shall also tender to Landlord reasonable attorney’s fees and other costs or overhead expenses incurred by Landlord in reviewing Tenant’s request for such Transfer (not to exceed $3,000). 

26.3 Landlord, in determining whether consent should be given to a proposed Transfer, may give consideration to (a) the financial
strength of such transferee, assignee or sublessee (notwithstanding Tenant remaining liable for Tenant’s performance), (b) any change in use that such transferee, assignee or sublessee proposes to make in the use of the Premises and
(c) Landlord’s desire to exercise its rights under Section 26.9 to cancel this Lease. 
 26.4 In no event
shall Landlord be deemed to be unreasonable for declining to consent to a Transfer to a transferee, assignee or sublessee of poor reputation, lacking financial qualifications or seeking a change in the Permitted Use, or jeopardizing directly or
indirectly the status of Landlord or any of Landlord’s affiliates as a Real Estate Investment Trust under the Internal Revenue Code of 1986. Notwithstanding anything contained in this Lease to the contrary, (w) no Transfer shall be
consummated on any basis such that the rental or other amounts to be paid by the occupant, assignee, manager or other transferee thereunder would be based, in whole or in part, on the income or profits derived by the business activities of such
occupant, assignee, manager or other transferee; (x) Tenant shall not furnish or render any services to an occupant, assignee, manager or other transferee with respect to whom transfer consideration is required to be paid, or manage or operate
the Premises or any capital additions so transferred, with respect to which transfer consideration is being paid; (y) Tenant shall not consummate a Transfer with any person in which Landlord owns an interest, directly or indirectly (by applying
constructive ownership rules set forth in Section 856(d)(5) of the Internal Revenue Code (“Revenue Code”); and (z) Tenant shall not consummate a Transfer with any person or in any manner that could cause any portion of the
amounts received by Landlord pursuant to this Lease or any sublease, license or other arrangement 

  
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for the right to use, occupy or possess any portion of the Premises to fail to qualify as “rents from real property” within the meaning of Section 856(d) of the Revenue Code, or
any similar or successor provision thereto or which could cause any other income of Landlord to fail to qualify as income described in Section 856(c)(2) of the Revenue Code. 

26.5 As conditions precedent to Tenant subleasing the Premises or to Landlord considering a request by Tenant to Tenant’s transfer
of rights or sharing of the Premises, Landlord may require any or all of the following: 
 (a) Tenant shall remain fully liable
under this Lease during the unexpired Term; 
 (b) Tenant shall provide Landlord with evidence reasonably satisfactory to
Landlord that the value of Landlord’s interest under this Lease shall not be diminished or reduced by the proposed Transfer. Such evidence shall include, without limitation, evidence respecting the relevant business experience and financial
responsibility and status of the proposed transferee, assignee or sublessee; 
 (c) If Tenant’s transfer of rights or
sharing of the Premises provides for the receipt by, on behalf of or on account of Tenant of any consideration of any kind whatsoever (including, without limitation, a premium rental for a sublease or lump sum payment for an assignment, but
excluding Tenant’s reasonable costs in marketing and subleasing the Premises) in excess of the rental and other charges due to Landlord under this Lease, Tenant shall pay fifty percent (50%) of all of such excess to Landlord, provided that
Tenant may first recover transaction costs incurred by Tenant, including marketing expenses, tenant improvement allowances actually provided by Tenant, construction costs, alterations, cash concessions, brokerage commissions, attorneys’ fees
and free rent. If said consideration consists of cash paid to Tenant, payment to Landlord shall be made upon receipt by Tenant of such cash payment; 
 (d) The proposed transferee, assignee or sublessee shall agree that, in the event Landlord gives such proposed transferee, assignee or sublessee notice that Tenant is in default under this Lease, such
proposed transferee, assignee or sublessee shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments shall be received by Landlord without any liability being incurred by Landlord, except to credit such payment
against those due by Tenant under this Lease, and any such proposed transferee, assignee or sublessee shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however,
that in no event shall Landlord or its Lenders, successors or assigns be obligated to accept such attornment; 
 (e)
Landlord’s consent to any such Transfer shall be effected on Landlord’s forms; 
 (f) Tenant shall not then be in
default beyond applicable notice and cure periods hereunder in any respect; 

  
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 (g) Such proposed transferee, assignee or sublessee’s use of the Premises shall be the
same as the Permitted Use; 
 (h) Landlord shall not be bound by any provision of any agreement pertaining to the Transfer,
except for Landlord’s written consent to the same; 
 (i) Tenant shall pay all transfer and other taxes (including
interest and penalties) assessed or payable for any Transfer; 
 (j) Landlord’s consent (or waiver of its rights) for any
Transfer shall not waive Landlord’s right to consent to any later Transfer; 
 (k) Tenant shall deliver to Landlord one
executed copy of any and all written instruments evidencing or relating to the Transfer; and 
 (l) A list of Hazardous
Materials (as defined in Section 40.8 below), certified by the proposed transferee, assignee or sublessee to be true and correct, that the proposed transferee, assignee or sublessee intends to use or store in the Premises. Additionally,
Tenant shall deliver to Landlord, on or before the date any proposed transferee, assignee or sublessee takes occupancy of the Premises, all of the items relating to Hazardous Materials of such proposed transferee, assignee or sublessee as described
in Section 40.2. 
 26.6 Any Transfer that is not in compliance with the provisions of this Article 26
shall be void and shall, at the option of Landlord, terminate this Lease. 
 26.7 The consent by Landlord to a Transfer shall
not relieve Tenant or proposed transferee, assignee or sublessee from obtaining Landlord’s consent to any further Transfer, nor shall it release Tenant or any proposed transferee, assignee or sublessee of Tenant from full and primary liability
under this Lease. 
 26.8 Notwithstanding any Transfer, Tenant shall remain fully and primarily liable for the payment of all
Rent and other sums due or to become due hereunder, and for the full performance of all other terms, conditions and covenants to be kept and performed by Tenant. The acceptance of Rent or any other sum due hereunder, or the acceptance of performance
of any other term, covenant or condition thereof, from any person or entity other than Tenant shall not be deemed a waiver of any of the provisions of this Lease or a consent to any Transfer. 

26.9 If Tenant delivers to Landlord a Transfer Notice indicating a desire to assign the Lease or otherwise Transfer this Lease or all or
substantially all of the Premises to a proposed transferee, assignee or sublessee for all or substantially all of the Term (other than an Exempt Transfer), then Landlord shall have the option, exercisable by giving notice to Tenant at any time
within ten (10) days after Landlord’s receipt of such Transfer Notice, to terminate this Lease as of the date specified in the Transfer Notice as the Transfer Date, except for those provisions that, by their express terms, survive the
expiration or earlier termination hereof. For purposes of the preceding sentence, “substantially all of the Term” shall mean that the proposed transfer would 

  
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expire during the last one (1) year of the Term. If Landlord exercises such option, then Tenant shall have the right to withdraw such Transfer Notice by delivering to Landlord written notice
of such election within five (5) days after Landlord’s delivery of notice electing to exercise Landlord’s option to terminate this Lease. In the event Tenant withdraws the Transfer Notice as provided in this Section 26.8,
this Lease shall continue in full force and effect. No failure of Landlord to exercise its option to terminate this Lease shall be deemed to be Landlord’s consent to a proposed Transfer. 

26.10 If Tenant sublets the Premises or any portion thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security
for Tenant’s obligations under this Lease, all rent from any such subletting, and appoints Landlord as assignee for Tenant, and Landlord (or a receiver for Tenant appointed on Landlord’s application) may collect such rent and apply it
toward Tenant’s obligations under this Lease; provided that, until the occurrence of a Default by Tenant, Tenant shall have the right to collect such rent. 
 27. Attorneys’ Fees. If either party commences an action against the other party arising out of or in connection with this Lease, then the substantially prevailing party shall be entitled to
have and recover from the other party reasonable attorneys’ fees, charges and disbursements and costs of suit. 
 28.
Bankruptcy. In the event a debtor, trustee or debtor in possession under the Bankruptcy Code, or another person with similar rights, duties and powers under any other Applicable Laws, proposes to cure any default under this Lease or to assume
or assign this Lease and is obliged to provide adequate assurance to Landlord that (a) a default shall be cured, (b) Landlord shall be compensated for its damages arising from any breach of this Lease and (c) future performance of
Tenant’s obligations under this Lease shall occur, then such adequate assurances shall include any or all of the following, as designated by Landlord in its sole and absolute discretion: 

28.1 Those acts specified in the Bankruptcy Code or other Applicable Laws as included within the meaning of “adequate
assurance,” even if this Lease does not concern a shopping center or other facility described in such Applicable Laws; 

28.2 A prompt cash payment to compensate Landlord for any monetary defaults or actual damages arising directly from a breach of this
Lease; 
 28.3 A cash deposit in an amount at least equal to the then-current amount of the Security Deposit; or 

28.4 The assumption or assignment of all of Tenant’s interest and obligations under this Lease. 

29. Definition of Landlord. With regard to obligations imposed upon Landlord pursuant to this Lease, the term
“Landlord,” as used in this Lease, shall refer only to Landlord or Landlord’s then-current successor-in-interest. In the event of any transfer, assignment or conveyance of Landlord’s interest in this Lease or in
Landlord’s fee title to or leasehold interest in the Property, as 

  
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applicable, Landlord herein named (and in case of any subsequent transfers or conveyances, the subsequent Landlord) shall be automatically freed and relieved, from and after the date of such
transfer, assignment or conveyance, from all liability for the performance of any covenants or obligations contained in this Lease thereafter to be performed by Landlord (except for return of the Security if Landlord’s assignee does not assume
the obligation to repay the Security Deposit to Landlord) and, without further agreement, the transferee, assignee or conveyee of Landlord’s in this Lease or in Landlord’s fee title to or leasehold interest in the Property, as applicable,
shall be deemed to have assumed and agreed to observe and perform any and all covenants and obligations of Landlord hereunder during the tenure of its interest in the Lease or the Property. Landlord or any subsequent Landlord may transfer its
interest in the Premises or this Lease without Tenant’s consent. 
 30. Estoppel Certificate. Tenant shall, within
ten (10) days of receipt of written notice from Landlord, execute, acknowledge and deliver a statement in writing substantially in the form attached to this Lease as Exhibit E, or on any other form reasonably requested by a proposed
Lender or purchaser, (a) certifying that this Lease is unmodified and in full force and effect (or, if modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to
which rental and other charges are paid in advance, if any, (b) acknowledging that there are not, to Tenant’s knowledge, any uncured defaults on the part of Landlord hereunder, or specifying such defaults if any are claimed, and
(c) setting forth such further reasonable information with respect to this Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any prospective purchaser or encumbrancer of all or any portion of the real
property of which the Premises are a part such that Tenant shall be stopped from arguing facts contrary to the express assertions of the estoppel. If Tenant fails to deliver such statement within such prescribed time, then such estoppel shall be
binding upon Tenant that the Lease is in full force and effect and without modification except as may be represented by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution. 

31. Joint and Several Obligations. If more than one person or entity executes this Lease as Tenant, then: 

31.1 Each of them is jointly and severally liable for the keeping, observing and performing of all of the terms, covenants, conditions,
provisions and agreements of this Lease to be kept, observed or performed by Tenant; and 
 31.2 The term
“Tenant” as used in this Lease shall mean and include each of them, jointly and severally. The act of, notice from, notice to, refund to, or signature of any one or more of them with respect to the tenancy under this Lease,
including, without limitation, any renewal, extension, expiration, termination or modification of this Lease, shall be binding upon each and all of the persons executing this Lease as Tenant with the same force and effect as if each and all of them
had so acted, so given or received such notice or refund, or so signed. 
 32. Limitation of Landlord’s Liability.

 32.1 If Landlord is in default under this Lease and, as a consequence, Tenant recovers a monetary judgment against Landlord,
the judgment shall be satisfied only out of (a) the 

  
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proceeds of sale received on execution of the judgment and levy against the right, title and interest of Landlord in the Building and the Project of which the Premises are a part, (b) rent,
insurance proceeds or other income from such real property receivable by Landlord or (c) the consideration received by Landlord from the sale, financing, refinancing or other disposition of all or any part of Landlord’s right, title or
interest in the Building or the Project of which the Premises are a part. 
 32.2 Landlord shall not be personally liable for
any deficiency under this Lease. If Landlord is a partnership or joint venture, then the partners of such partnership shall not be personally liable for Landlord’s obligations under this Lease, and no partner of Landlord shall be sued or named
as a party in any suit or action, and service of process shall not be made against any partner of Landlord except as may be necessary to secure jurisdiction of the partnership or joint venture. If Landlord is a corporation, then the shareholders,
directors, officers, employees and agents of such corporation shall not be personally liable for Landlord’s obligations under this Lease, and no shareholder, director, officer, employee or agent of Landlord shall be sued or named as a party in
any suit or action, and service of process shall not be made against any shareholder, director, officer, employee or agent of Landlord. If Landlord is a limited liability company, then the members of such limited liability company shall not be
personally liable for Landlord’s obligations under this Lease, and no member of Landlord shall be sued or named as a party in any suit or action, and service of process shall not be made against any member of Landlord except as may be necessary
to secure jurisdiction of the limited liability company. No partner, shareholder, director, employee, member or agent of Landlord shall be required to answer or otherwise plead to any service of process, and no judgment shall be taken or writ of
execution levied against any partner, shareholder, director, employee or agent of Landlord. 
 32.3 Each of the covenants and
agreements of this Article 32 shall be applicable to any covenant or agreement either expressly contained in this Lease or imposed by Applicable Laws and shall survive the expiration or earlier termination of this Lease. 

33. Project Control by Landlord. 
 33.1 Landlord reserves full control over the Building and the Project to the extent not inconsistent with Tenant’s enjoyment of the Premises as provided by this Lease. This reservation includes,
without limitation, Landlord’s right to subdivide the Project, convert the Building to condominium units, grant easements and licenses to third parties, and maintain or establish ownership of the Building separate from fee title to the
Property. 
 33.2 Tenant shall, at Landlord’s request, promptly execute such further reasonable documents as may be
reasonably appropriate to assist Landlord in the performance of its obligations hereunder; provided that Tenant need not execute any document that creates additional liability for Tenant, that materially adversely affects Tenant or that
deprives Tenant of the quiet enjoyment and use of the Premises as provided by this Lease. 
 33.3 Landlord may, at any and all
reasonable times during non-business hours (or during business hours if Tenant so requests), and upon one (1) business day prior written or facsimile notice (provided that no time restrictions shall apply or advance notice be required if
an 

  
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emergency necessitates immediate entry), enter the Premises to (a) inspect the same and to determine whether Tenant is in compliance with its obligations hereunder, (b) supply any
service Landlord is required to provide hereunder, (c) show the Premises to prospective purchasers or tenants during the final year of the Term, (d) post notices of nonresponsibility, (e) access the telephone equipment, electrical
substation and fire risers and (f) alter, improve or repair any portion of the Building other than the Premises for which access to the Premises is reasonably necessary. For any such access to the Premises, Landlord shall, except in an
emergency, permit a representative of Tenant to accompany Landlord, and at all times agrees to comply with Tenant’s reasonable security and safety rules that are orally communicated to Landlord’s representative accessing the Premises at
the time or access and/or provided to Landlord in writing. In connection with any such alteration, improvement or repair as described in Subsection 33.3(f) above, Landlord may erect in the Premises or elsewhere in the Project scaffolding
and other structures reasonably required for the alteration, improvement or repair work to be performed. In no event shall Tenant’s Rent abate as a result of Landlord’s activities pursuant to this Section 33.3; provided,
however, that all such activities shall be conducted in such a manner so as to cause as little interference to Tenant as is reasonably possible. Landlord shall at all times retain a key with which to unlock all of the doors in the Premises.
If an emergency necessitates immediate access to the Premises, Landlord may use whatever force is necessary to enter the Premises, and any such entry to the Premises shall not constitute a forcible or unlawful entry to the Premises, a detainer of
the Premises, or an eviction of Tenant from the Premises or any portion thereof. 
 34. Quiet Enjoyment. So long as
Tenant is not in default beyond applicable notice and cure periods under this Lease, Landlord or anyone acting through or under Landlord shall not disturb Tenant’s occupancy of the Premises, except as permitted by this Lease. 

35. Subordination and Attornment. 
 35.1 This Lease shall be subject and subordinate to the lien of any mortgage, deed of trust, or lease in which Landlord is tenant now or hereafter in force against the Building or the Project (each an
“Encumbrance”) and to all advances made or hereafter to be made upon the security thereof without the necessity of the execution and delivery of any further instruments on the part of Tenant to effectuate such subordination, according to
the following terms and conditions. 
 35.2 Landlord shall endeavor, no later than twenty (20) days after the date of full
execution of this Lease, to provide Tenant, without cost or charge, with commercially reasonable subordination, non-disturbance and attornment agreements (“SNDA”) in favor of Tenant from any ground lessors, mortgage holders or lien
holders (each, a “Superior Mortgagee”) then in existence. Without limitation, the SNDA shall provide that the Superior Mortgagee shall recognize this Lease, and in the event of any default under such Encumbrance or any foreclosure
action, forced sale, or other proceeding in connection therewith, the rights of Tenant under this Lease, and Tenant’s possession of the Premises shall not be disturbed, Tenant shall not be named as defendant in any such proceedings, and that in
the event such Superior Mortgagee becomes owner of the Premises, Building, Project or any part thereof, such holder shall accept Tenant as Tenant under this Lease, and, notwithstanding the foregoing, any such SNDA shall include customary limitations
on such 

  
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holder’s obligations to Tenant. Said SNDA shall be in recordable form and may be recorded at Tenant’s election and expense. In the event Landlord fails to provide such commercially
reasonable SNDA within the time frame set forth in this Section, Tenant shall have the right, as its sole and exclusive remedy, exercisable no later than thirty (30) days after the date of full execution of this Lease, to terminate this Lease
upon ten (10) business days written notice to Landlord. In the event Tenant elects to terminate this Lease and Landlord does not provide Tenant with the applicable SNDA within such ten (10) day period, this Lease shall terminate and
Landlord shall reimburse Tenant all of Tenant’s pre-paid rent. This provision shall survive the termination of this Lease. 

35.3 Notwithstanding the foregoing, Tenant’s subordination as provided above with respect to any Encumbrances arising after the date
of this Lease shall be conditioned upon Landlord providing Tenant with a commercially reasonable SNDA that without limitation complies with the preceding paragraph. Said SNDA shall be in recordable form and may be recorded at Tenant’s expense.

 35.4 Notwithstanding the foregoing, Tenant shall execute and deliver upon demand such further reasonable instrument or
instruments evidencing such subordination of this Lease to the lien of any such mortgage or mortgages or deeds of trust or lease in which Landlord is tenant as may be required by Landlord so long as the same are consistent with this
Article 35. However, if any such mortgagee, beneficiary or Landlord under lease wherein Landlord is tenant so elects, this Lease shall be deemed prior in lien to any such lease, mortgage, or deed of trust upon or including the Premises
regardless of date and Tenant shall execute a statement in writing to such effect at Landlord’s request. 
 35.5 Upon
written request of Landlord and opportunity for Tenant to review, Tenant agrees to execute any Lease amendments not materially altering the terms of this Lease, if required by a mortgagee or beneficiary of a deed of trust encumbering real property
of which the Premises constitute a part incident to the financing of the real property of which the Premises constitute a part. Any change materially affecting or changing Tenant’s use of the Premises, materially increasing Tenant’s costs
or liabilities, affecting the amount or timing of the consideration to be paid by Tenant or modifying the Term of this Lease shall be deemed as materially altering the terms hereof. 

35.6 In the event any proceedings are brought for foreclosure, or in the event of the exercise of the power of sale under any mortgage or
deed of trust made by Landlord covering the Premises, Tenant’s use and enjoyment of the Premises shall not be disturbed and Tenant shall attorn to the purchaser upon any such foreclosure or sale and recognize such purchaser as Landlord under
this Lease. 
 36. Surrender. 
 36.1 At lease ten (10) days prior to Tenant’s surrender of possession of any part of the Premises, Tenant shall provide Landlord with (a) a facility decommissioning and Hazardous Materials
closure plan for the Premises (“Exit Survey”), and (b) written evidence of all appropriate governmental releases obtained by Tenant in accordance with Applicable Laws, including, without

  
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limitation, laws pertaining to the surrender of the Premises. In addition, Tenant agrees to remain responsible after the surrender of the Premises for the remediation of any recognized
environmental conditions set forth in the Exit Survey and compliance with any recommendations set forth in the Exit Survey. Tenant’s obligations under this Section 36.1 shall survive the expiration or earlier termination of the
Lease. 
 36.2 No surrender of possession of any part of the Premises shall release Tenant from any of its obligations
hereunder, unless such surrender is accepted in writing by Landlord. 
 36.3 The voluntary or other surrender of this Lease by
Tenant shall not effect a merger with Landlord’s fee title or leasehold interest in the Premises, the Building or the Property, unless Landlord consents in writing, and shall, at Landlord’s option, operate as an assignment to Landlord of
any or all subleases. 
 36.4 The voluntary or other surrender of any ground or other underlying lease that now exists or may
hereafter be executed affecting the Building or the Project, or a mutual cancellation thereof or of Landlord’s interest therein by Landlord and its lessor shall not effect a merger with Landlord’s fee title or leasehold interest in the
Premises, the Building or the Property and shall, at the option of the successor to Landlord’s interest in the Building or the Project, as applicable, operate as an assignment of this Lease. 

37. Waiver and Modification. No provision of this Lease may be modified, amended or supplemented except by an agreement in writing
signed by Landlord and Tenant. The waiver by Landlord or Tenant of any breach by the other of any term, covenant or condition herein contained shall not be deemed to be a waiver of any subsequent breach of the same or any other term, covenant or
condition herein contained. 
 38. Waiver of Jury Trial and Counterclaims. The parties waive trial by jury in any action,
proceeding or counterclaim brought by the other party hereto related to matters arising out of or in any way connected with this Lease; the relationship between Landlord and Tenant; Tenant’s use or occupancy of the Premises, the Building or the
Project; or any claim of injury or damage related to this Lease or the Premises, the Building or the Project. 
 39.
Intentionally deleted. 
 40. Hazardous Materials. 

40.1 Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be brought upon, kept or used in or about the
Premises, the Building or the Project in violation of Applicable Laws by Tenant, its agents, employees, contractors or invitees. If Tenant breaches such obligation, or if the presence of Hazardous Materials as a result of such a breach results in
contamination of the Premises, the Building, the Project or any adjacent property, or if contamination of the Premises by Hazardous Materials otherwise occurs during the Term of this Lease or any extension or renewal hereof or holding over
hereunder, then Tenant shall indemnify, save, defend and hold Landlord, its agents and contractors harmless from and against any and all 

  
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claims, judgments, damages, penalties, fines, costs, liabilities and losses (including, without limitation, diminution in value of the Premises, the Building, the Project or any portion thereof;
damages for the loss or restriction on use of rentable or usable space or of any amenity of the Premises or Project; damages arising from any adverse impact on marketing of space in the Premises, the Building or the Project; and sums paid in
settlement of claims, attorneys’ fees, consultants’ fees and experts’ fees) that arise during or after the Term as a result of such breach or contamination. This indemnification of Landlord by Tenant includes, without limitation,
costs incurred in connection with any investigation of site conditions or any cleanup, remedial, removal or restoration work required by any Governmental Authority because of Hazardous Materials present in the air, soil or groundwater above, on or
under the Premises. Without limiting the foregoing, if the presence of any Hazardous Materials in, on, under or about the Premises, the Building, the Project or any adjacent property caused or permitted by Tenant results in any contamination of the
Premises, the Building, the Project or any adjacent property, then Tenant shall promptly take all actions at its sole cost and expense as are necessary to return the Premises, the Building, the Project and any adjacent property to their respective
condition existing prior to the time of such contamination; provided that Landlord’s written approval of such action shall first be obtained, which approval Landlord shall not unreasonably withhold; and provided, further,
that it shall be reasonable for Landlord to withhold its consent if such actions could have a material adverse long-term or short-term effect on the Premises, the Building or the Project. 

40.2 Landlord acknowledges that it is not the intent of this Article 40 to prohibit Tenant from operating its business as
described in Section 2.9 above. Tenant may operate its business according to the custom of Tenant’s industry so long as the use or presence of Hazardous Materials is strictly and properly monitored according to Applicable Laws. As a
material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the Term Commencement Date a list identifying each type of Hazardous Material to be present on
the Premises and setting forth any and all governmental approvals or permits required in connection with the presence of such Hazardous Material on the Premises (the “Hazardous Materials List”). Tenant shall deliver to Landlord an
updated Hazardous Materials List promptly after any material changes to the types or amounts of Hazardous Materials used by Tenant in the Premises. Tenant shall deliver to Landlord true and correct copies of the following documents (hereinafter
referred to as the “Documents”) relating to the handling, storage, disposal and emission of Hazardous Materials prior to the Term Commencement Date or, if unavailable at that time, concurrent with the receipt from or submission to
any Governmental Authority: permits; approvals; reports and correspondence; storage and management plans; notices of violations of Applicable Laws; plans relating to the installation of any storage tanks to be installed in or under the Premises, the
Building or the Project (provided that installation of storage tanks shall only be permitted after Landlord has given Tenant its written consent to do so, which consent Landlord may withhold in its sole and absolute discretion); and all
closure plans or any other documents required by any and all Governmental Authorities for any storage tanks installed in, on or under the Premises, the Building or the Project for the closure of any such storage tanks. Tenant shall not be required,
however, to provide Landlord with any portion of the Documents containing information of a proprietary nature that, in and of themselves, do not contain a reference to any Hazardous Materials or activities related to Hazardous Materials. Upon
Landlord’s written request, 

  
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Tenant agrees that it shall enter into a reasonable written agreement with other tenants of the Building and the Project concerning the equitable allocation of fire control areas (as defined in
the Uniform Building Code as adopted by the city or municipality(ies) in which the Project is located (the “UBC”)) within the Building and the Project for the storage of Hazardous Materials. In the event that Tenant’s use of
Hazardous Materials is such that it utilizes fire control areas in the Building or the Project in excess of Tenant’s Pro Rata Share of the Building or the Project, as applicable, as set forth in Section 2.2, Tenant agrees that it
shall, at its sole cost and expense and upon Landlord’s written request, establish and maintain a separate area of the Premises classified by the UBC as an “H” occupancy area for the use and storage of Hazardous Materials or take such
other action as is necessary to ensure that its share of the fire control areas of the Building and the Project is not greater than Tenant’s Pro Rata Share of the Building or the Project, as applicable. 

40.3 Notwithstanding the provisions of Section 40.1 above, if Tenant (a) has been required by any prior landlord, Lender
or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property if the contamination resulted from such party’s action or omission or use of the property in question, or (b) is subject to
an enforcement order issued by any Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, then Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute discretion (with
respect to any such matter involving Tenant) at any time within one hundred eighty (180) days after the date Landlord actually becomes aware of such requirement or order, as applicable; provided, however, that unless such property
is the Property, this Section 40.3 shall not apply to any assignee of Tenant that (x) purchases all or substantially all of the assets of Tenant, and (y) has a net worth of at least $100,000,000. 

40.4 Notwithstanding the provisions of Section 40.1 above, if any proposed transferee, assignee or sublessee of Tenant
(a) has been required by any prior landlord, Lender or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property if the contamination resulted from such party’s action or omission or use
of the property in question, or (b) is subject to an enforcement order issued by any Governmental Authority in connection with the use, disposal or storage of Hazardous Materials, then it shall not be unreasonable for Landlord to withhold its
consent to any proposed transfer, assignment or subletting (with respect to any such matter involving such proposed transferee, assignee or sublessee); provided, however, that this Section 40.4 shall not apply in the case
of any assignment of this Lease by Tenant to any assignee that (x) purchases all or substantially all of the assets of Tenant, and (y) has a net worth of at least $100,000,000. 

40.5 At any time, and from time to time, prior to the expiration of the Term, if Landlord has a reasonable basis to believe that Tenant
has violated this Article 40, Landlord shall have the right to conduct appropriate tests of the Premises, the Building and the Project to demonstrate that Hazardous Materials are present or that contamination has occurred due to Tenant
or Tenant’s agents, employees or invitees. Tenant shall pay all reasonable costs of such tests of the Premises if a violation by Tenant is found to have occurred. 

  
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 40.6 If underground or other storage tanks storing Hazardous Materials are located on the
Premises or are hereafter placed on the Premises by any party, Tenant shall monitor the storage tanks, maintain appropriate records, implement reporting procedures, properly close any underground storage tanks, and take or cause to be taken all
other steps necessary or required under the Applicable Laws. 
 40.7 Tenant’s obligations under this Article 40
shall survive the expiration or earlier termination of the Lease. During any period of time needed by Tenant or Landlord after the termination of this Lease to complete the removal from the Premises of any such Hazardous Materials, Tenant shall
continue to pay Rent in accordance with this Lease, which Rent shall be prorated daily. 
 40.8 As used herein, the term
“Hazardous Material” means any hazardous or toxic substance, material or waste that is or becomes regulated by any Governmental Authority. 
 41. Miscellaneous. 
 41.1 Where applicable in this Lease, the singular
includes the plural and the masculine or neuter includes the masculine, feminine and neuter. The section headings of this Lease are not a part of this Lease and shall have no effect upon the construction or interpretation of any part hereof.

 41.2 Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for
a lease, and shall not be effective as a lease or otherwise until execution by and delivery to both Landlord and Tenant. 
 41.3
Time is of the essence with respect to the performance of every provision of this Lease in which time of performance is a factor. 
 41.4 Each provision of this Lease performable by Tenant or Landlord shall be deemed both a covenant and a condition. 
 41.5 Whenever consent or approval of either party is required, that party shall not unreasonably withhold, condition or delay such consent or approval, except as may be expressly set forth to the
contrary. 
 41.6 The terms of this Lease are intended by the parties as a final expression of their agreement with respect to
the terms as are included herein, and may not be contradicted by evidence of any prior or contemporaneous agreement. 
 41.7 Any
provision of this Lease that shall prove to be invalid, void or illegal shall in no way affect, impair or invalidate any other provision hereof, and all other provisions of this Lease shall remain in full force and effect and shall be interpreted as
if the invalid, void or illegal provision did not exist. 

  
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 41.8 Landlord may, but shall not be obligated to, record this Lease or a short form
memorandum hereof if approved by Tenant, which consent shall not be unreasonably withheld, conditioned or delayed. Neither party shall record this Lease. Landlord shall be responsible for the cost of recording any memorandum of this Lease, including
any transfer or other taxes incurred in connection with said recordation. 
 41.9 The language in all parts of this Lease shall
be in all cases construed as a whole according to its fair meaning and not strictly for or against either Landlord or Tenant. 

41.10 Each of the covenants, conditions and agreements herein contained shall inure to the benefit of and shall apply to and be binding
upon the parties hereto and their respective heirs; legatees; devisees; executors; administrators; and permitted successors, assigns, sublessees. Nothing in this Section 41.10 shall in any way alter the provisions of this Lease
restricting assignment or subletting. 
 41.11 Any notice, consent, demand, bill, statement or other communication required or
permitted to be given hereunder shall be in writing and shall be given by personal delivery, overnight delivery with a reputable nationwide overnight delivery service, or certified mail (return receipt requested), and if given by personal delivery,
shall be deemed delivered upon receipt; if given by overnight delivery, shall be deemed delivered one (1) day after deposit with a reputable nationwide overnight delivery service; and, if given by certified mail (return receipt requested),
shall be deemed delivered three (3) business days after the time the notifying party deposits the notice with the United States Postal Service. Any notices given pursuant to this Lease shall be addressed to Tenant at the Premises, or to
Landlord or Tenant at the addresses shown in Sections 2.11 and 2.12, respectively. Either party may, by notice to the other given pursuant to this Section, specify additional or different addresses for notice purposes. 

41.12 This Lease shall be governed by, construed and enforced in accordance with the laws of the State in which the Premises are located,
without regard to such State’s conflict of law principles. 
 41.13 Each of Landlord and Tenant warrant to the other that
the respective individual or individuals signing this Lease on its behalf has the power, authority and legal capacity to sign this Lease on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers
or other organizations and entities on whose behalf said individual or individuals have signed. 
 41.14 Tenant agrees that it
shall promptly furnish to Landlord, from time to time, upon Landlord’s written request, the most recent audited year-end financial statements reflecting Tenant’s current financial condition or, to the extent audited financial statements
are not available, year-end financial statements certified by Tenant’s chief financial officer as prepared in conformance with GAAP as it is related to accrued liabilities and fairly representing Tenant’s current financial condition.
Tenant represents and warrants that all financial statements, records and information furnished by Tenant to Landlord in connection with this Lease are true, correct and complete in all material respects. 

  
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 41.15 This Lease may be executed in one or more counterparts, each of which, when taken
together, shall constitute one and the same document. 
 41.16 Landlord warrants that there are no recorded covenants,
conditions or restrictions on the Project or Property (the “CC&Rs”) that materially interfere with Tenant’s ability to use the Premises for the Permitted Use. 

42. Option to Extend Term. Tenant shall have the option (“Option”) to extend the Term of this Lease by five
(5) years (the “Extension Term”) as to the entire Premises (and no less than the entire Premises) upon the following terms and conditions. Any extension of the Term pursuant to the Option shall be on all the same terms and
conditions as this Lease, except as follows: 
 42.1 Basic Annual Rent shall be adjusted on the first (1st) day of the
Extension Term and each anniversary date thereof in accordance with Article 7. The Basic Annual Rent during the Extension Term shall equal the greater of: (a) ninety-five percent (95%) of the Fair Market Value for the Extension
Term; and (b) 103% of the then-current Basic Annual Rent at the end of the then-current Term, and shall be adjusted in accordance with Article 7 hereof. “Fair Market Value” means the then-prevailing average annual
rate that comparable landlords have accepted in current transactions from new, non-equity (i.e., not being offered equity in the Building), nonrenewal, nonexpansion and nonaffiliated tenants of similar financial strength for comparable space in
comparable laboratory buildings comparably located, with comparable size, quality and floor height in a first class office building, or as appropriate, a laboratory building, taking into consideration all relevant factors, including, without
limitation, the proposed lease term, the tenant inducements, free rent, brokerage commissions, allowances or concessions, if any, and excluding specialized tenant improvements or tenant paid improvements for a comparable term, with the determination
of Fair Market Value to take into account all relevant factors, including tenant inducements, allowances or concessions, if any, the extent of the services provided or to be provided to the Premises, and contraction and expansion options. In the
event the tenant inducements, allowances or concessions granted differ from the terms contained in this Lease, an adjustment to the Fair Market Value shall be made on a basis consistent with the adjustments commonly made in the market for comparable
differences and concession packages. If Landlord and Tenant cannot agree on the Fair Market Value for purposes of the Extension Term then they shall engage a mutually agreeable independent third party appraiser with at least ten
(10) years’ experience in appraising the rental value of leased commercial premises (for research and development and laboratory uses) in the Seattle, Washington area (the “Appraiser”). If the parties cannot agree on the
Appraiser, each shall within ten (10) days after such impasse appoint an Appraiser and, within ten (10) days after the appointment of both such Appraisers, those two Appraisers shall select a third. If either party fails to timely appoint
an Appraiser, then the Appraiser the other party appoints shall be the sole Appraiser. Within ten (10) days after appointment of all Appraiser(s), Landlord and Tenant shall each simultaneously give the Appraisers (with a copy to the other
party) its determination of Fair Market Value, with such supporting data or information as each submitting party determines appropriate. Within ten (10) days after such submissions, the Appraisers shall by majority vote select either
Landlord’s or Tenant’s Fair Market Value. The Appraisers may not select or designate any other Fair Market Value. The determination of the Appraiser(s) shall bind the parties. 

  
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 42.2 The Option is not assignable separate and apart from this Lease except that it shall be
exercisable by a Tenant’s Affiliate to which this Lease has been assigned in accordance herewith. 
 42.3 The Option is
conditional upon Tenant giving Landlord written notice of its election to exercise the Option at least nine (9) months prior to the end of the expiration of the initial Term of this Lease. Time shall be of the essence as to Tenant’s
exercise of the Option. Tenant assumes full responsibility for maintaining a record of the deadlines to exercise the Option. Tenant acknowledges that it would be inequitable to require Landlord to accept any exercise of the Option after the date
provided for in this paragraph. 
 42.4 Notwithstanding anything contained in this Article 42, Tenant shall not have
the right to exercise the Option: 
 (a) During the time commencing from the date Landlord delivers to Tenant a written notice
that Tenant is actually in default under any provisions of this Lease and continuing until Tenant has cured the specified default to Landlord’s reasonable satisfaction; or 

(b) At any time after any Default as described in Article 25 of the Lease and continuing until Tenant cures any such
Default, if such Default is susceptible to being cured; or 
 (c) In the event that Tenant has defaulted (beyond applicable
notice and cure periods) in the performance of its obligations under this Lease two (2) or more times and a service or late charge has become payable under Section 25.1 for each of such defaults during the twelve (12)-month period
immediately prior to the date that Tenant intends to exercise the Option, whether or not Tenant has cured such defaults. 
 42.5
The period of time within which Tenant may exercise the Option shall not be extended or enlarged by reason of Tenant’s inability to exercise such Option because of the provisions of Section 42.4. 

42.6 All of Tenant’s rights under the provisions of the Option shall terminate and be of no further force or effect even after
Tenant’s due and timely exercise of the Option if, after such exercise, but prior to the commencement date of the new term, (a) Tenant fails to pay to Landlord a monetary obligation of Tenant for a period of twenty (20) days after
written notice from Landlord to Tenant, (b) Tenant fails to commence to cure a default (other than a monetary default) within thirty (30) days after the date Landlord gives notice to Tenant of such default or (c) Tenant has defaulted
(beyond applicable notice and cure periods) under this Lease two (2) or more times and a service or late charge under Section 25.1 has become payable for any such default, whether or not Tenant has cured such defaults. 

43. Right of First Refusal. Tenant shall have a continuing right of first refusal (“ROFR”) as to any premises on
the first and third floors of the Building for which Landlord is seeking a tenant (“Available Premises”) from time to time during the Term and extensions thereof. To the extent that Landlord renews or extends a then-existing lease
with any then-existing tenant of any space, or 

  
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enters into a new lease with such then-existing tenant for the same premises, the affected space shall not be deemed to be Available Premises. In addition, space that has not been rented since
the completion of the Building shall be Available Premises. In the event Landlord makes to a third party, or receives from a third party, a offer to lease Available Premises that Landlord is willing to accept, Landlord shall provide written notice
thereof to Tenant (the “Notice of Offer”), specifying the terms and conditions of a proposed lease to Tenant of the Available Premises. 
 43.1 Within ten (10) days following its receipt of a Notice of Offer, Tenant shall advise Landlord in writing whether Tenant elects to lease the Available Premises on the terms and conditions set
forth in such Notice of Offer. If Tenant fails to notify Landlord of Tenant’s election within said ten (10) day period, then Tenant shall be deemed to have elected not to lease the Available Premises. 

43.2 If Tenant timely notifies Landlord that Tenant elects to lease the Available Premises on the terms and conditions set forth in the
Notice of Offer, then Landlord shall lease the Available Premises to Tenant upon the terms and conditions set forth in the Notice of Offer. 
 43.3 If Tenant notifies Landlord that Tenant elects not to lease the Available Premises on the terms and conditions set forth in the Notice of Offer, or if Tenant fails to notify Landlord of Tenant’s
election within the ten (10)-day period described above, then Landlord shall have the right to consummate the lease of the Available Premises on the same terms as are in the Notice of Offer, or on terms that, in Landlord’s reasonable, good
faith judgment, are more favorable to Landlord or on other terms than are set forth in the Notice of Offer (provided that each of (a) the size of any prospective subject space to be let, (b) the aggregate economic value based on the
discounted present value (to be calculated with an eight percent (8%) annual interest factor) of the net rent and other amounts to be paid by the tenant and the Landlord over the term of the lease of such space and the amount of the tenant
improvement allowance, and (c) the length of the term of such prospective lease does not vary by more than seven and one-half percent (7.5%) from those set forth in the Notice of Offer), within one hundred twenty (120) days following
Tenant’s election (or deemed election) not to lease the Available Premises. If Landlord does not lease the Available Premises within said one hundred twenty (120)-day period, then Tenant’s ROFR shall be fully reinstated with respect to the
specific Available Premises, and Landlord shall not thereafter lease the Available Premises without first complying with the procedures set forth in this Article 43. 

43.4 Notwithstanding anything in this Article 43 to the contrary, Tenant shall not exercise the ROFR during such period of
time that Tenant is in default beyond applicable notice and cure periods under any provision of this Lease. Any attempted exercise of the ROFR during a period of time in which Tenant is so in default shall be void and of no effect. In addition,
Tenant shall not be entitled to exercise the ROFR if Tenant has been in default (beyond applicable notice and cure periods) two (2) or more times during the twelve (12) month period prior to the date on which Tenant seeks to exercise the
ROFR. 
 43.5 Notwithstanding anything in this Lease to the contrary, Tenant shall not assign or transfer the ROFR, either
separately or in conjunction with an assignment or transfer of Tenant’s interest in the Lease, without Landlord’s prior written consent, which consent Landlord may withhold in its sole and absolute discretion; provided that this
ROFR shall be exercisable by Tenant’s Affiliate to which this Lease has been assigned in accordance with the terms hereof. 

  
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 43.6 If Tenant exercises the ROFR, Landlord does not guarantee that the Available Premises
will be available on the anticipated commencement date for the lease thereof if the then-existing occupants of the Additional Space shall hold over, or for any other reason beyond Landlord’s reasonable control. 

43.7 Notwithstanding anything in this Lease to the contrary, if the Available Premises consists of all or any portion of the first
(1St) floor, Tenant at its sole discretion may elect to exercise this ROFR with respect to all of such space on the first (1st) floor or with respect to only such portion thereof as Tenant may elect (so long as the portion of the first
(1st) floor that Tenant does not elect to lease is, in Landlord’s reasonable judgment, reasonably marketable). 
 44.
Expansion Option. 
 44.1 Subject to the conditions set forth in this Article 44, Tenant shall have the
right, but not the obligation, to expand the Premises (the “Expansion Option”) to include space in the basement or on the first floor of the Building (the “Potential Expansion Area”). The portion of the Potential
Expansion Area added to the Premises by exercise of the Expansion Option shall herein be referred to as the “Expansion Premises”. 
 44.2 Tenant may exercise its Expansion Option under this Article 44 for any portion of the Potential Expansion Area that remains Available Space by providing Landlord with written notice (the
“Expansion Option Exercise Notice”) that Tenant has elected to exercise its Expansion Option for such space. A portion of the space in the Building shall be deemed “Available Space” if such portion is vacant and Tenant has
not received a Notice of Offer in accordance with Article 43 with respect to such portion. 
 44.3 Tenant
acknowledges that Landlord shall have the right at any time in its sole and absolute discretion to make improvements in addition to the Core and Shell Work to any portion of the Potential Expansion Area for which Tenant has not exercised its
Expansion Option such that such portion of the Potential Expansion Area will be ready for tenant occupancy (even if such portion of the Potential Expansion Area will not be suitable for Tenant’s use) (such improvements, “Spec
Improvements”). If Landlord intends to make Spec Improvements to any portion of the Potential Expansion Area, then Landlord shall endeavor to provide written notice to Tenant when Landlord applies for a building permit for the Spec
Improvements, which notice shall state Landlord’s intent to complete such Spec Improvements in such portion of the Potential Expansion Area (such portion of the Potential Expansion Area that is described in a Spec Space Notice (as defined
below) as the portion that will be so improved, a “Spec Space Area”), and specify the general nature of the Spec Improvements and the Spec Space Area (such notice, a “Spec Space Notice”). If Tenant desires to lease
less than all of the Spec Space Area, then the Expansion Premises shall be determined in accordance with Section 44.4, and such Spec Space Area shall be the Expansion Premises hereunder. If Tenant delivers an Expansion Option Exercise
Notice with respect to any Spec Space Area before Landlord commences the Spec Improvements in such Spec 

  
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Space Area, then, in its Expansion Option Exercise Notice, Tenant may clearly and explicitly notify Landlord that Tenant does not desire Landlord to complete the Spec Improvements (a
“Non-Spec Election”), and if Tenant timely provides such notice to Landlord, then Landlord shall not perform the Spec Improvements in such Spec Space Area, and instead the improvement of such Spec Space shall be governed by
Section 44.5. If Tenant does not make a Non-Spec Election in Tenant’s Expansion Option Exercise Notice, then Landlord shall perform the Spec Improvements in such Spec Space Area (a “Leased Spec Area”), and shall not
be required to perform any improvements in addition to the Core and Shell Work and the Spec Improvements, and Tenant shall not be entitled to any TI Allowance for the Leased Spec Area. 

44.4 If Tenant exercises its Expansion Option in accordance with Section 44.2 hereof with respect to: 

(a) any Spec Space Area, then Tenant shall, in its Expansion Option Exercise Notice, specify the number of square feet of Rentable Area
of Spec Space Area that Tenant requires. It Tenant requests less than the entire Rentable Area of Spec Space Area in its Expansion Option Exercise Notice, then Landlord shall subsequently designate as the Expansion Premises a portion of such Spec
Space Area, reasonably suitable for leasing and comprised of a number of square feet of Rentable Area that is approximately the same as the number of square feet of Rentable Area that is specified by Tenant in its Expansion Option Exercise Notice,
but only if there is Spec Space Area that meets each of the following requirements: 
 (i) The Rentable Area of such space is
approximately the same as the Rentable Area designated by Tenant in its Expansion Option Exercise Notice; and 
 (ii) Landlord
can separately demise such space in a reasonable manner so that (i) such space and (ii) the remaining space located on such floor of the Building (if any) are of a commercially reasonable and marketable configuration and are suitable for
leasing, including having access to the common areas on the applicable floor (in the case of (ii) above, without reducing the rent per square foot that such remaining space would be expected to attain on the open market). 

(b) any portion of the Potential Expansion Area for which Landlord has not delivered a Spec Space Notice and which is Available Space
(“Available Non-Spec Space”), then Tenant shall, in its Expansion Option Exercise Notice, specify the number of square feet of Rentable Area of Available Non-Spec Space that Tenant requires. Landlord shall subsequently designate as
the Expansion Premises a portion of the Potential Expansion Area that is Available Non-Spec Space, reasonably suitable for leasing and comprised of a number of square feet of Rentable Area that is approximately the same as the number of square feet
of Rentable Area that is specified by Tenant in its Expansion Option Exercise Notice, but only if there is Potential Expansion Area that meets each of the following requirements: 

(i) The Rentable Area of such space is approximately the same as the Rentable Area designated by Tenant in its Expansion Option Exercise
Notice; 

  
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 (ii) Landlord can separately demise such space in a reasonable manner so that (i) such
space and (ii) the remaining space located on such floor of the Building (if any) are of a commercially reasonable and marketable configuration and are suitable for leasing, including having access to the common areas on the applicable floor
(in the case of (ii) above, without reducing the rent per square foot that such remaining space would be expected to attain on the open market); 
 (iii) Such space is Available Non-Spec Space; and 
 (iv) Landlord has not
delivered a Spec Space Notice with respect to such space. 
 Tenant shall pay all costs and expenses of separately demising the Expansion
Premises. 
 44.5 In the event Tenant exercises its Expansion Option in accordance with the terms of this Article 44
with respect to Available Non-Spec Space or any Spec Space Area for which Tenant has made a Non-Spec Election, Tenant may, by providing written notice to Landlord at any time during the twelve (12) month period (the “Expansion Tenant
Improvement Election Period”) immediately following the later of the date of the Expansion Option Exercise Notice provided by Tenant to Landlord for such space or Substantial Completion of the Core and Shell Work, request in writing (the
“Expansion Premises TI Notice”) that Landlord construct tenant improvements to such Expansion Premises in accordance with the terms of Article 4 of this Lease and the Work Letter (with such modifications thereto as may
reasonably be necessary to reflect that the Tenant Improvements for such Expansion Premises will be governed by this Article 44 to the extent inconsistent with Article 44); provided, however, Tenant shall
deliver its Draft Plans for the Expansion Premises Tenant Improvements to Landlord within sixty (60) days after Tenant provides its Expansion Premises TI Notice for such Expansion Premises to Landlord; provided, further, that the
TI Allowance for such Expansion Premises shall be treated separately for such Expansion Premises and determined based on the rentable square footage of the Expansion Premises; provided, further, that Tenant shall have until the earlier
of (a) the occurrence of a Default after notice and the lapse of any applicable cure periods (which shall be the notice and cure periods specified in Article 25 and not additional notice or cure periods) or (b) the expiration
of the Expansion Tenant Improvement Election Period, to expend the unused portion of any TI Allowance with respect to such Expansion Premises, after which date Landlord’s obligation to fund the TI Allowance for such Expansion Premises shall
expire, and any Tenant Improvements made by Landlord to the applicable Expansion Premises after such date shall be made at Tenant’s sole cost and expense. Tenant and Landlord shall amend the Work Letter to incorporate any additional tenant
improvements requested by Tenant in accordance with this Section 44.5 within ten (10) days following Tenant’s provision of such notice to Landlord. 
 44.6 Within ten (10) days after exercising the Expansion Option, Tenant and Landlord shall enter into a written amendment to this Lease (the “Amendment”), which Amendment shall
provide, unless otherwise agreed in writing: 
 (a) that the term commencement date for the Expansion Premises (the
“Expansion Space Term Commencement Date”) shall be the later of (i) the date of Substantial Completion of the Core and Shell Work and Tenant Improvements (or Spec Improvements in lieu of Tenant Improvements for any Leased Spec
Area) for the Expansion Premises or (ii) the Term Commencement Date for the initial Premises; 

  
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 (b) that the Premises under this Lease shall be increased to include the Expansion Premises
as of the Expansion Space Term Commencement Date; 
 (c) that the Rentable Area of the Premises shall be increased to reflect
the inclusion of the Rentable Area of the Expansion Premises as of the Expansion Space Term Commencement Date; 
 (d) the new
Basic Annual Rent, with the Expansion Premises increasing the Basic Annual Rent as set forth in Section 44.8 hereof, provided, however, that if a Fair Market Rental Value determination is required in connection with such
increase and the new Basic Annual Rent is therefore not known at the time of execution of the Amendment, the Amendment shall indicate that the new Basic Annual Rent shall be determined in accordance with Section 44.8 of this Lease;

 (e) unless such Expansion Premises are Leased Spec Area, that Tenant shall commence paying Basic Annual Rent, and
Tenant’s Share of Operating Expenses, for any Expansion Premises commencing upon the later of (i) ten (10) days following the date of the Expansion Option Exercise Notice provided by Tenant to Landlord with respect to the Expansion
Premises, or (ii) eight (8) months following the the later of (A) the date of the Expansion Option Exercise Notice provided by Tenant to Landlord with respect to the Expansion Premises, or (B)the Substantial Completion of the Core and
Shell Work for such Expansion Premises, or (iii) the Rent Commencement Date; 
 (f) if such Expansion Premises are Leased
Spec Area, that Tenant shall commence paying Basic Annual Rent, and Tenant’s Share of Operating Expenses, for any Expansion Premises commencing upon the later of (i) ten (10) days following the date of the Expansion Option Exercise
Notice provided by Tenant to Landlord with respect to the Expansion Premises, or (ii) Substantial Completion of the Spec Improvements for the Leased Spec Area, or (iii) the Rent Commencement Date; 

(g) Tenant’s new Pro Rata Share of Operating Expenses based upon the addition of the Rentable Area of the Expansion Premises to the
Premises; 
 (h) the proportionate increase to the Security Deposit (which increase shall be payable to Landlord upon execution
of the Amendment); and 
 (i) the amount of the Initial TI Allowance and Additional TI Allowance (which amount shall exclude
any TI Allowance for Leased Spec Space). 

  
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 44.7 Landlord shall endeavor to tender possession of the Expansion Premises (with the Tenant
Improvements thereto (or Spec Improvements in lieu of Tenant Improvements for any Leased Spec Area) Substantially Complete) to Tenant on or before the estimated delivery date for the Expansion Premises (the “Expansion Estimated Delivery
Date”). If the Tenant Improvements (or Spec Improvements in lieu of Tenant Improvements for any Leased Spec Area) are not Substantially Complete on or before the Expansion Estimated Delivery Date for any reason whatsoever, then this Lease
shall not be void or voidable, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and the Expansion Space Term Commencement Date shall not occur until Substantial Completion of the Tenant Improvements for the
Expansion Premises occurs. Substantial Completion of Tenant Improvements for the Expansion Premises shall be determined separately from Substantial Completion for the remainder of the Premises. 

44.8 The initial Basic Annual Rent for the Expansion Premises shall be calculated as follows: 

(a) Unless the Expansion Premises is Leased Spec Area: 
 (i) if the Expansion Option is exercised from and after the Execution Date until the Term Commencement Date, then the initial Basic Annual Rent for such Expansion Premises shall be the rental rate per
square foot of Rentable Area of the Expansion Premises set forth in Section 2.3 hereof; 
 (ii) if the Expansion
Option is exercised from and after the Teen Commencement Date until the first anniversary of the Term Commencement Date, then the initial Basic Annual Rent for such Expansion Premises shall be the Fair Market Rental Value of the Expansion Premises
(not to exceed 110% of the initial Basic Annual Rent per square foot of Rentable Area set forth in Section 2.3 hereof); 
 (iii) if the Expansion Option is exercised after the first anniversary of the Term Commencement Date, then the initial Basic Annual Rent for such Expansion Premises shall be the Fair Market Rental Value
of the Expansion Premises; and 
 (b) If the Expansion Premises is Leased Spec Space, then the initial Basic Annual Rent for
such Expansion Premises shall be the Fair Market Rental Value for such space and improvements thereto with respect to such space, in which case Tenant shall not be entitled to any TI Allowance in connection with such Expansion Premises. 

Basic Annual Rent for the Expansion Premises shall escalate in accordance with Article 7 of this Lease. 

For purposes of this Article 44, the term “Fair Market Rental Value” of the Expansion Premises is the greater of
(a) the rental rate per square foot of Rentable Area of the Expansion Premises set forth in Section 2.3 hereof, or (b) the rental rate, determined in accordance with this Article 44, at which tenants are leasing
Comparable Space on the Expansion Space Term Commencement Date. For this purpose, “Comparable Space” shall mean office and laboratory 

  
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space that is (v) not subleased, (w) not subject to another tenant’s expansion rights, (x) comparable in size, location and quality to the Expansion Premises, (y) leased
for a term comparable to Tenant’s lease of the Expansion Premises and (z) located in the Building and in other comparable office and laboratory projects located in the Seattle, Washington area. In determining the rental rate of Comparable
Space, the parties shall exclude brokerage commissions and shall include all escalations and take into consideration the following concessions: (i) rental abatement concessions, if any, being granted to tenants in connection with the Comparable
Space and (ii) tenant improvements or allowances provided or to be provided for the Comparable Space, taking into account the TI Allowance for, or value of the Spec Improvements in, the Expansion Premises, as the case may be. 

For any portion of the Expansion Premises for which Tenant has exercised its Expansion Option Exercise Notice and for which Basic Annual
Rent will be determined based on the Fair Market Rental Value of the Expansion Premises, Landlord shall provide written notice to Tenant of Landlord’s determination of the Fair Market Rental Value (“LL FMV Notice”) within
fifteen (15) business days following Landlord’s receipt of such Expansion Option Exercise Notice from Tenant. If Tenant disagrees with Landlord’s determination of the Fair Market Rental Value of the portion of the Expansion Premises
as set forth in the LL FMV Notice, then Tenant shall provide written notice to Landlord within ten (10) days following Tenant’s receipt of the LL FMV Notice notifying Landlord thereof (“Tenant FMV Objection Notice”).

 If Tenant does not deliver its Tenant FMV Objection Notice to Landlord by the end of such ten (10) day period, then the
Fair Market Rental Value of the Expansion Premises shall conclusively be determined to be the Fair Market Rental Value set forth in the LL FMV Notice. 
 If Tenant does deliver its Tenant FMV Objection Notice to Landlord by the end of such ten (10) day period, then Landlord and Tenant shall diligently attempt in good faith to agree upon the Fair
Market Rental Value for such portion of the Expansion Premises on or before the fifth (5th) business day after Landlord’s receipt of the Tenant FMV Objection Notice. If Landlord and Tenant fail to reach agreement on or before such date,
the matter shall be arbitrated by a single arbitrator in accordance with Commercial Arbitration Rules of the American Arbitration Association. The arbitrator’s decision shall be limited to determining the Fair Market Rental Value of such
portion of the Expansion Premises. The arbitrator shall have no authority to make any other rulings or fashion any other remedy. The decision of the arbitrator shall be final. The party losing the arbitration shall reimburse the prevailing party for
all of the prevailing party’s reasonable fees, costs and expenses of the arbitration, including reasonable attorneys’ fees and the arbitrator’s fees. 
 44.9 Landlord shall use good faith efforts to cause Contractor to repair any defects in the Expansion Premises identified by Tenant to Landlord within nine (9) months of Tenant’s occupation of
the Expansion Premises. Notwithstanding the foregoing, Landlord warrants that as of the Expansion Space Tenn Commencement Date (a) the Expansion Premises shall substantially comply with all Applicable Laws; (b) any portion of the Expansion
Premises consisting of Spec Space Area shall be constructed substantially in conformance with Landlord’s plans for such Spec Space Area, (c) any portion of the Expansion Premises consisting of Available Non-Spec Space or for which Tenant
makes a Non-Spec Election shall be constructed substantially in accordance with 

  
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the Approved TI Plans and the Approved Core and Shell Plans for such space; and (d) the Expansion Premises shall be watertight. To the extent any of the warranties set forth in the preceding
sentence are violated, Landlord shall promptly correct the same at its sole cost. 
 44.10 Notwithstanding anything in this
Article 44 to the contrary, Tenant shall not exercise the Expansion Option during such period of time that Tenant is in default under any provision of this Lease after notice and the lapse of any applicable cure periods. Any attempted
exercise of the Expansion Option during a period of time in which Tenant is so in default shall be void and of no effect. In addition, Tenant shall not be entitled to exercise the Expansion Option if Landlord has given Tenant two (2) or more
notices of default under this Lease, whether or not the defaults are cured prior to the date on which Tenant seeks to exercise the Expansion Option. 
 45. Tenant Option to Terminate. Tenant shall have the option to terminate this Lease (the “Termination Option”) with no further rights or obligations hereunder in the event that
Tenant (a) enters into a new lease for space in another building which is directly or indirectly owned or controlled by BioMed Realty Trust, Inc. (each, a “BioMed Entity”) and (b) notifies Landlord and such BioMed Entity
at least five (5) business days before Tenant executes such new Lease that Tenant is exercising such Termination Option and that Tenant intends to terminate this Lease. Tenant shall exercise the Termination Option, if at all, within three
(3) business days after Tenant enters into such a new lease. If Tenant enters into such a new lease and exercises the Termination Option in such a manner, then this Lease shall be deemed to expire fifteen (15) days after Tenant commences
to pay rent under such other lease, subject to all of the terms and conditions of this Lease with respect to the obligations of Landlord and Tenant upon expiration of this Lease. Nothing in this Lease is intended to provide Tenant with any rights in
any other such building, including any right to lease space in such a building, and neither Landlord nor any affiliate of Landlord (including any BioMed Entity) shall have any obligation to negotiate with or otherwise entertain offers from Tenant
with respect to any such space. The Termination Option shall not entitle Tenant to terminate the Lease with respect to less than all of the Premises. 
 46. Authority. Tenant hereby covenants and warrants that (a) Tenant is duly incorporated or otherwise established or formed and validly existing under the laws of its state of incorporation,
establishment or formation, (b) Tenant has and is duly qualified to do business in the state in which the Property is located, (c) Tenant has full corporate, partnership, trust, association or other appropriate power and authority to enter
into this Lease and to perform all Tenant’s obligations hereunder and (d) each person (and all of the persons if more than one signs) signing this Lease on behalf of Tenant is duly and validly authorized to do so. 

47. Confidentiality. Tenant shall not disclose any terms or conditions of this Lease (including Rent) or give a copy of this Lease
to any third party, and Landlord shall not release to any third party any nonpublic financial information or nonpublic information about Tenant’s ownership structure, business or research (“Tenant Information”), except
(a) if required by Applicable Laws or in any judicial proceeding, provided that the releasing party has given the other party reasonable notice of such requirement, if feasible, (b) to a party’s attorneys, accountants, brokers
and other bona fide consultants or advisers, provided such third parties agree to be bound by this paragraph or (c) to bona fide prospective assignees or subtenants of this Lease. Landlord shall not use any nonpublic Tenant Information
in connection with any trading by Landlord of the capital stock of Tenant. 

  
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 48. Odors and Exhaust. Tenant acknowledges that Landlord would not enter into this
Lease with Tenant unless Tenant assured Landlord that under no circumstances will any other occupants of the Building or Project (including persons legally present in any outdoor areas of the Project) be subjected to reasonably offensive odors or
fumes (whether or not noxious), and that the Building and Project will not be damaged by any exhaust, in each case from Tenant’s operations. Landlord acknowledges that Tenant is a laboratory user, and that as such there may be odors and exhaust
generated that differ from those generated by an office user. Landlord and Tenant therefore agree as follows: 
 48.1 Tenant
shall not cause or permit (or conduct any activities that would cause) any release of any reasonably offensive odors or fumes of any kind from the Premises. 
 48.2 The Building has a ventilation system that in Landlord’s judgment (and taking Tenant’s Permitted Use of the Premises into account) is adequate, suitable, and appropriate to vent the
Premises in a manner that does not release odors affecting any indoor or outdoor part of the Project, and Tenant agrees to vent the Premises through such system. The placement and configuration of any further ventilation exhaust pipes, louvers and
other equipment shall be subject to Landlord’s reasonable approval. Subject to the foregoing, Tenant acknowledges Landlord’s legitimate desire to maintain the Project (indoor and outdoor areas) in a reasonably odor-free manner (taking into
account that the Building is a laboratory building), and Landlord may reasonably require Tenant to abate and remove all odors in a manner that goes beyond the requirements of Applicable Laws. 

48.3 If Tenant’s activities in the Premises generate odors that are not vented by the Building’s ventilation system (as
described in the prior paragraph), and if such odors are reasonably offensive to other tenants, then Tenant shall, at Tenant’s sole cost and expense, provide odor eliminators and other devices (such as filters, air cleaners, scrubbers and
whatever other equipment may in Landlord’s reasonable judgment be necessary or appropriate from time to time) to reasonably abate any odors, fumes or other substances in Tenant’s exhaust stream that, in Landlord’s reasonable judgment,
emanate from Tenant’s Premises. Any work Tenant performs under this paragraph shall constitute Alterations. 
 48.4
Tenant’s responsibility to abate odors, fumes and exhaust shall continue throughout the Term. Landlord’s approval of the Tenant Improvements shall not preclude Landlord from requiring additional measures to eliminate odors, fumes and other
adverse impacts of Tenant’s exhaust stream (as Landlord may designate in Landlord’s reasonable discretion). Tenant shall install additional equipment as Landlord reasonably requires from time to time under the preceding sentence. Such
installations shall constitute Alterations. 
 48.5 If Tenant fails to install satisfactory odor control equipment within twenty
(20) business days after Landlord’s demand (as set forth above) made at any time, then Landlord may, without limiting Landlord’s other rights and remedies, require Tenant to cease and suspend any

  
 -62-

 
operations in the Premises that, in Landlord’s determination, cause odors, fumes or exhaust. For example, if Landlord reasonably determines that Tenant’s production of a certain type of
product causes odors, fumes or exhaust, and Tenant does not install satisfactory odor control equipment within twenty (20) business days after Landlord’s request, then Landlord may require Tenant to stop producing such type of product in
the Premises unless and until Tenant has installed odor control equipment satisfactory to Landlord. 
 49. HVAC. For the
Premises, Landlord shall (a) maintain and operate the heating, ventilating and air conditioning systems used for typical laboratory use (“HVAC”), and (b) subject to clause (a) above, furnish HVAC as reasonably
required (except as this Lease otherwise provides or as to any special requirements that arise from Tenant’s particular use of the Premises for other than typical laboratory use) for reasonably comfortable occupancy of the Premises twenty-four
(24) hours a day, 365 or 366 days a year. If Tenant will require HVAC outside normal business hours of business days (as reasonably designated by Landlord) in the Premises (“Overtime HVAC”), then Landlord shall be obligated to
provide Overtime HVAC only if Tenant requests it by 4 p.m. on the immediately preceding business day. Notwithstanding anything to the contrary in this paragraph, Landlord shall have no liability, and Tenant shall have no right or remedy, on account
of any interruption or impairment in HVAC services, except as otherwise set forth in this Lease, and provided that Landlord diligently endeavors to cure any such interruption or impairment. 

50. Excavation. If any excavation shall be made upon land adjacent to or under the Building, or shall be authorized to be made,
Tenant shall afford to the person causing or authorized to cause such excavation, reasonable license to enter the Premises for the purpose of performing such work as said person shall deem necessary or desirable to preserve and protect the Building
from injury or damage and to support the same by proper foundations, without any claim for damages or liability against Landlord and without reducing or otherwise affecting Tenant’s obligations under this Lease so long as Tenant’s use and
enjoyment of the Premises is not materially interfered with. 
 51. Names. Landlord reserves the right to change the name
of the Project or the Building in its sole discretion. 
 52. Good Faith. As used herein, the term “good faith”
shall be subjective in nature (based on the perspective of the person or entity that is acting). A decision shall be deemed to be made in “good faith” if the person who makes the decision believes (without regard to whether such belief is
reasonable) that it is appropriate and is made without dishonesty or fraud; and “good faith efforts” shall mean such efforts as the person or entity that takes such actions believes (without regard to whether such belief is reasonable) are
appropriate under the circumstances or likely to achieve the desired result. 
 53. Substantially Conform or Comply.
References in this Lease to “substantially conform” or “substantially comply” shall mean that the item in question complies but for issues that do not result in material additional incremental costs to Tenant or materially
interfere with Tenant’s ability to use or enjoy the Premises in accordance with the Lease. 
 [REMAINDER OF THIS PAGE
INTENTIONALLY LEFT BLANK] 

  
 -63-

 IN WITNESS WHEREOF, the parties hereto have executed this Lease as of the date first above
written. 
  

			
	LANDLORD:
	
	 BMR-530 FAIRVIEW AVENUE LLC,
 a Delaware limited liability company

		
	By:	 	 /s/ Kent Griffin

	Name:	 	 Kent Griffin

	Title:	 	 CFO

	
	TENANT:
	
	 NANOSTRING TECHNOLOGIES, INC.,
 a Delaware corporation

		
	By:	 	 /s/ Wayne Burns

	Name:	 	 Wayne Burns

	Title:	 	 CFO

  
 [SIGNATURE
PAGE TO LEASE] 

 NOTARIZATION (required in the State of Washington) 

STATE OF CALIFORNIA) 

                         
   : ss. 
 COUNTY OF San Diego) 
 I certify that I know or have satisfactory evidence that Kent Griffin is the person who appeared before me, and s/he acknowledged that s/he signed this instrument, on oath stated that s/he was
authorized to execute the instrument and acknowledged it as the Chief Financial Officer of BMR-530 Fairview LLC, a corporation, to be the free and voluntary act of such corporation for the uses and purposes mentioned in the instrument.

 Dated this 25 day of October, 2007. 

 

	
	 /s/ Christy D. Bartlett

	[Signature of Notary]
	
	 Christy D. Bartlett

	[Print Name of Notary]

 STATE OF WASHINGTON) 
                             : ss. 

COUNTY OF King) 
 I
certify that I know or have satisfactory evidence that Wayne Burns is the person who appeared before me, and s/he acknowledged that s/he signed this instrument, on oath stated that s/he was authorized to execute the instrument and
acknowledged it as the Chief Financial Officer of NanoString Technologies, a corporation, to be the free and voluntary act of such corporation for the uses and purposes mentioned in the instrument. 

Dated this 19 day of October, 2007. 

 

	
	 /s/ Susan R. Van Den Ameele

	[Signature of Notary]
	
	 Susan R. Van Den Ameele

	[Print Name of Notary]
	
	Notary Public in and for the State of
	Washington, residing at Seattle.
	My commission expires: 09.21.11.

  
 [SIGNATURE
PAGE TO LEASE] 

 EXHIBIT A 

PREMISES 

SECOND FLOOR 
  

 

  
 

 

 EXHIBIT B 
 ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE 
 AND TERM EXPIRATION DATE

 THIS ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE AND TERM EXPIRATION DATE is entered into as of
[            ], 20[    ], with reference to that certain Lease (the “Lease”) dated as of October 19, 2007, by NANOSTRING TECHNOLOGIES, INC., a
Delaware corporation (“Tenant”), in favor of BMR-350 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”). All capitalized terms used herein without definition shall have the meanings ascribed to
them in the Lease. 
 Tenant hereby confirms the following: 

1. Tenant accepted possession of the Premises on [            ],
20[    ]. 
 2. To the best of Tenant’s knowledge after reasonable investigation, the Premises are in
good order, condition and repair. 
 3. To the best of Tenant’s knowledge after reasonable investigation, the Tenant
Improvements required to be constructed by Landlord under the Lease have been substantially completed. 
 4. To the best of
Tenant’s knowledge after reasonable investigation, all conditions of the Lease to be performed by Landlord as a condition to the full effectiveness of the Lease have been satisfied, and Landlord has fulfilled all of its duties in the nature of
inducements offered to Tenant to lease the Premises. Tenant acknowledges that the Term Commencement Date shall not be delayed as a result of any issues discovered by Tenant during such investigation. 

5. Notwithstanding the failure of any conditions to the occurrence of the Term Commencement Date, in accordance with the provisions of
Section 4.2 of the Lease, the Term Commencement Date is [            ], 20[    ], and, unless the Lease is terminated prior to the Term Expiration Date
pursuant to its terms, the Term Expiration Date shall be [            ], 20[    ]. 
 6. Tenant commenced occupancy of the Premises for the Permitted Use on [            ], 20[    ]. 

7. The Lease is in full force and effect, and the same represents the entire agreement between Landlord and Tenant concerning the
Premises[, except [            ]]. 
 8. To the best of
Tenant’s knowledge after reasonable investigation, Tenant has no existing defenses against the enforcement of the Lease by Landlord, and there exist no offsets or credits against Rent owed or to be owed by Tenant. 

  
 B-1

 9. The obligation to pay Rent is presently in effect and all Rent obligations on the part of
Tenant under the Lease commenced to accrue on [            ], 20[    ]. 
 10. The undersigned Tenant has not made any prior assignment, transfer, hypothecation or pledge of the Lease or of the rents thereunder or sublease of the Premises or any portion thereof. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
 B-2

 IN WITNESS WHEREOF, the parties hereto have executed this Acknowledgment of Term
Commencement Date and Term Expiration Date as of [            ], 20[    ]. 
  

			
	TENANT:
	
	 NANOSTRING TECHNOLOGIES, INC.
 a Delaware corporation

		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 B-3

 EXHIBIT C 
 [INTENTIONALLY DELETED] 

  
 C-1

 EXHIBIT D 
 RULES AND REGULATIONS 
 NOTHING IN THESE RULES AND REGULATIONS (“RULES AND
REGULATIONS”) SHALL SUPPLANT ANY PROVISION OF THE LEASE. IN THE EVENT OF A CONFLICT OR INCONSISTENCY BETWEEN THESE RULES AND REGULATIONS AND THE LEASE, THE LEASE SHALL PREVAIL. 

1. Except as specifically provided in the Lease to which these Rules and Regulations are attached, no sign, placard, picture,
advertisement, name or notice shall be installed or displayed on any part of the outside of the Premises or the Building without Landlord’s prior written consent. Landlord shall have the right to remove, at Tenant’s sole cost and expense
and without notice, any sign installed or displayed in violation of this rule. 
 2. If Landlord objects in writing to any
curtains, blinds, shades, screens or hanging plants or other similar objects attached to or used in connection with any window or door of the Premises or placed on any windowsill, which window, door or windowsill is (a) visible from the
exterior of the Premises and (b) not included in plans approved by Landlord, then Tenant shall promptly remove said curtains, blinds, shades, screens or hanging plants or other similar objects at its sole cost and expense. 

3. Tenant shall not obstruct any sidewalks or entrances to the Building, or any halls, passages, exits, entrances or stairways within the
Premises, in any case that are required to be kept clear for health and safety reasons. 
 4. No deliveries shall be made that
impede or interfere with other tenants in or the operation of the Project. 
 5. Tenant shall not place a load upon any floor of
the Premises that exceeds the load per square foot that (a) such floor was designed to carry or (b) that is allowed by Applicable Laws. Fixtures and equipment that cause noises or vibrations that may be transmitted to the structure of the
Building to such a degree as to be objectionable to other tenants shall be placed and maintained by Tenant, at Tenant’s sole cost and expense, on vibration eliminators or other devices sufficient to eliminate such noises and vibrations to
levels reasonably acceptable to Landlord and other tenants of the Building. 
 6. Tenant shall not use any method of heating or
air conditioning other than that shown in the Tenant Improvement plans. 
 7. Tenant shall not install any radio, television or
other antenna, cell or other communications equipment, or any other devices on the roof or exterior walls of the Premises except to the extent shown on approved Tenant Improvements plans. Tenant shall not interfere with radio, television or other
communications from or in the Premises or elsewhere. 

  
 D-1

 8. Canvassing, peddling, soliciting and distributing handbills or any other written material
within, on or around the Project (other than within the Premises) are prohibited and Tenant shall cooperate to prevent such activities. 
 9. Tenant shall store all of its trash, garbage and Hazardous Materials within its Premises or in designated receptacles outside of the Premises. Tenant shall not place in any such receptacle any material
that cannot be disposed of in the ordinary and customary manner of trash, garbage and Hazardous Materials disposal. 
 10. The
Premises shall not be used for any improper, immoral or objectionable purpose. No cooking shall be done or permitted on the Premises; provided, however, that Tenant may use (a) equipment approved in accordance with the
requirements of insurance policies that Landlord or Tenant is required to purchase and maintain pursuant to the Lease for brewing coffee, tea, hot chocolate and similar beverages, (b) microwave ovens for employees’ use and
(c) equipment shown on Tenant Improvement plans approved by Landlord; provided, further, that any such equipment and microwave ovens are used in accordance with Applicable Laws. 

11. Tenant shall not, without Landlord’s prior written consent, use the name of the Project, if any, in connection with or in
promoting or advertising Tenant’s business except as Tenant’s address. 
 12. Tenant shall comply with all safety,
fire protection and evacuation procedures and regulations established by Landlord or any Governmental Authority. 
 13. Tenant
assumes any and all responsibility for protecting the Premises from theft, robbery and pilferage, which responsibility includes keeping doors locked and other means of entry to the Premises closed. 

14. Landlord may waive any one or more of these Rules and Regulations for the benefit of Tenant or any other tenant, but no such waiver
by Landlord shall be construed as a waiver of such Rules and Regulations in favor of Tenant or any other tenant, nor prevent Landlord from therafter enforcing any such Rules and Regulations against any or all of the tenants of the Project, including
Tenant. 
 15. These Rules and Regulations are in addition to, and shall not be construed to in any way modify or amend, in
whole or in part, the terms covenants, agreements and conditions of the Lease. 
 16. Landlord reserves the right to make such
other and reasonable rules and regulations as, in its judgment, may from time to time be needed for safety and security, the care and cleanliness of the Project, or the preservation of good order therein; provided, however, that
Landlord shall provide written notice to Tenant of such rules and regulations prior to them taking effect. Tenant agrees to abide by these Rules and Regulations and any additional reasonable rules and regulations issued or adopted by Landlord.

  
 D-2

 17. Tenant shall be responsible for the observance of these Rules and Regulations by
Tenant’s employees, agents, clients, customers, invitees and guests. 

  
 D-3

 EXHIBIT E 
 FORM OF ESTOPPEL CERTIFICATE 
  

			
	To:	  	BMR-530 FAIRVIEW AVENUE LLC
		  	17140 Bernardo Center Drive, Suite 222
		  	San Diego, CA 92128
		  	Attention: General Counsel/Real Estate
		
		  	BioMed Realty, L.P.
		  	c/o BioMed Realty Trust, Inc.
		  	17140 Bernardo Center Drive, Suite 222
		  	San Diego, CA 92128
		
	Re:	  	Fairview Research Center (the “Premises”) at 530 Fairview Avenue, Seattle, Washington (the “Property”)

 The undersigned tenant (“Tenant”) hereby certifies to you as follows: 

1. Tenant is a tenant at the Property under a lease (the “Lease”) for the Premises dated as of October 19, 2007.
The Lease has not been cancelled, modified, assigned, extended or amended [except as follows: [            ]], and there are no other agreements, written or oral, affecting or relating to
Tenant’s lease of the Premises or any other space at the Property. The lease term expires on [            ], 20[    ]. 

2. Tenant took possession of the Premises, currently consisting of
[            ] square feet, on [            ], 20[    ], and commenced to pay rent on
[            ], 20[    ]. Tenant has full possession of the Premises, has not assigned the Lease or sublet any part of the Premises, and does not hold the Premises under
an assignment or sublease[, except as follows: [            ]]. 

3. All base rent, rent escalations and additional rent under the Lease have been paid through
[            ], 20[    ]. There is no prepaid rent[, except $[            ][, and the amount of security
deposit is $[            ][in cash] [in the form of a letter of credit]]. Tenant currently has no right to any future rent abatement under the Lease. 

4. Base rent is currently payable in the amount of $[            ] per month.

 5. Tenant is currently paying estimated payments of additional rent of
$[            ] per month on account of real estate taxes, insurance, management fees and common area maintenance expenses. 

6. All work to be performed for Tenant under the Lease has been performed as required under the Lease and has been accepted by Tenant[,
except [            ]], and all allowances to be paid to Tenant, including allowances for tenant improvements, moving expenses or other items, have been paid. 

  
 E-1

 7. To the best of Tenant’s knowledge after due investigation, the Lease is in full
force and effect, free from default and free from any event that could become a default under the Lease, and Tenant has no claims against the landlord or offsets or defenses against rent, and there are no disputes with the landlord. Tenant has
received no notice of prior sale, transfer, assignment, hypothecation or pledge of the Lease or of the rents payable thereunder[, except [            ]]. 

8. [Tenant has the following expansion rights or options for the Property:
[            ]. [Tenant has no rights or options to purchase the Property.] 
 9. To the best of Tenant’s knowledge, no hazardous wastes have been generated, treated, stored or disposed of by or on behalf of Tenant in, on or around the Premises or the Project in violation of
any environmental laws. 
 10. The undersigned has executed this Estoppel Certificate with the knowledge and understanding that
[INSERT NAME OF LANDLORD, PURCHASER OR LENDER, AS APPROPRIATE] or its assignee is acquiring the Property in reliance on this certificate and that the undersigned shall be bound by this certificate. The statements contained herein may be relied upon
by [INSERT NAME OF PURCHASER OR LENDER, AS APPROPRIATE], BMR-530 Fairview Avenue LLC, BioMed Realty, L.P., BioMed Realty Trust, Inc., and any mortgagee of the Property and their respective successors and assigns. 

Any capitalized terms not defined herein shall have the respective meanings given in the Lease. 

Dated this [    ] day of [            ], 20[    ].

  

			
	NANOSTRING TECHNOLOGIES, INC.,
	a Delaware corporation
		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 E-2

 EXHIBIT F 
 [INTENTIONALLY DELETED] 

 EXHIBIT G 
 WORK LETTER 
 This Work Letter (the “Work Letter”)
is made and entered into as of the 19th day of October, 2007, by and between BMR-530 FAIRVIEW AVENUE LLC, a Delaware limited liability company (“Landlord”), and NANOSTRING TECHNOLOGIES, INC., a Delaware corporation
(“Tenant”), and is attached to and made a part of that certain Lease dated as of October 19, 2007 (the “Lease”), by and between Landlord and Tenant for the Premises located at 530 Fairview Avenue in Seattle,
Washington. All capitalized terms used but not otherwise defined herein shall have the meanings given them in the Lease. 
 1. General
Requirements. 
 1.1 Tenant’s Authorized Representative. Tenant designates Wayne Burns (“Tenant’s
Authorized Representative”) as the person authorized to initial all plans, drawings, changes orders and approvals pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any such item until such item has been
initialed by Tenant’s Authorized Representative. 
 1.2 Core and Shell Work Schedule. The schedule for the design
and development of Core and Shell Work (as defined in the Lease), including, without limitation, the time periods for preparation and review of construction documents, approvals and performance, shall be in accordance with that certain schedule
prepared by Landlord and Tenant attached as Exhibit A-1 to this Work Letter (the “Core and Shell Work Schedule”). The Core and Shell Work Schedule shall be subject to adjustment as mutually agreed upon in writing by
the parties, or as provided in this Work Letter. 
 1.3 Tenant Improvements Schedule. The schedule for the design and
development of Tenant Improvements (as defined in the Lease), including, without limitation, the time periods for preparation and review of construction documents, approvals and performance, shall be in accordance with that certain schedule prepared
by Landlord and Tenant attached as Exhibit A-2 to this Work Letter (the “Tenant Improvements Schedule”). The Tenant Improvements Schedule shall be subject to adjustment as mutually agreed upon in writing by the
parties, or as provided in this Work Letter. 
 1.4 Architects and Consultants. The architect, engineering consultants,
design team, general contractor and subcontractors responsible for the construction of Landlord’s Work shall be selected by Landlord and approved by Tenant, which approval Tenant shall not unreasonably withhold, condition or delay. Tenant
hereby approves of Mithun Incorporated as Landlord’s architect and M.A. Mortenson Company as Landlord’s general contractor for the Core and Shell Work. 
 1.5 Construction Management Fee. Tenant shall pay Landlord a construction management fee in exchange for Landlord’s performance of the Tenant Improvements pursuant to Section 3
hereof equal to the lesser of (a) three percent (3%) of the TI Costs, and (b) Forty Thousand Dollars ($40,000) (the “Construction Management Fee”). 

  
 G-1

 2. Core and Shell Work. 
 2.1 Core and Shell Work. Core and Shell Work shall be performed by Landlord at Landlord’s sole cost and expense in accordance with the Approved Core and Shell Plans (as defined below) and the
Core and Shell Work Schedule, subject only to changes approved in accordance with Section 2.3. 
 2.2 Approved
Core and Shell Plans. Landlord shall prepare final plans and specifications for Core and Shell Work that are: (a) consistent with and are logical evolutions of the Design Development Drawings attached as Exhibit B which have
been approved by the parties, (b) incorporate Core and Shell Permitted Changes, and (c) incorporate any other Landlord-requested Core and Shell Changes that do not materially adversely impact Tenant (provided that if any such change
increases Tenant’s costs, the same shall be borne by Landlord). As soon as such final plans and specifications (“Final Core and Shell Plans”) are completed, Landlord shall deliver the same to Tenant for Tenant’s approval,
which approval may be withheld only if: (i) the Final Core and Shell Plans are not consistent with or logical evolutions of the approved Design Development Drawings, (ii) Tenant requests changes to the Final Core and Shell Plans in
accordance with Section 2.3(a)(i), or (iii) Tenant objects to any Landlord requested Core and Shell Change (other than Core and Shell Permitted Changes). Such Final Core and Shell Plans shall be approved or disapproved by Tenant
within ten (10) days after delivery to Tenant. Tenant shall not unreasonably withhold its approval of the Final Core and Shell Plans. If Tenant fails to notify Landlord of disapproval within this ten (10) day period, then the Final Core
and Shell Plans shall be deemed approved. If the Final Core and Shell Plans are disapproved by Tenant, Tenant shall notify Landlord in writing of its objections to such Final Core and Shell Plans and shall submit any requested Core and Shell Changes
through a Core and Shell Tenant Change Order Request (as defined below), and the parties shall confer and negotiate in good faith to reach agreement on the Final Core and Shell Plans. Promptly after the Final Core and Shell Plans are approved by
Landlord and Tenant, two (2) copies of such Final Core and Shell Plans shall be initialed and dated by Landlord and Tenant as soon as approved by Landlord and Tenant, Landlord shall promptly submit such Final Core and Shell Plans to all
appropriate governmental agencies for approval. The Final Core and Shell Plans so approved, and all change orders specifically permitted by this Agreement, are referred to herein as the “Approved Core and Shell Plans” and shall become part
of this Lease as though set forth in full. 

  
 G-2

 2.3 Changes to Core and Shell Work. Any changes to the Final Core and Shell Plans or
the Approved Core and Shell Plans (each, a “Core and Shell Change”) requested by Landlord or Tenant (other than Core and Shell Permitted Changes made by Landlord) shall be requested and instituted in accordance with the provisions of this
Article 2 and shall be subject to the written approval of the other party in accordance with this Work Letter. 

(a) Core and Shell Changes Requested by Tenant. 
 (i) Core and Shell Tenant Change Order Request. Tenant may request Core and Shell Changes to the Final Core and Shell Plans or the Approved Core and Shell Plans by notifying Landlord thereof in
writing in substantially the same form as the AIA standard change order form (a “Core and Shell Tenant Change Order Request”), which Core and Shell Tenant Change Order Request shall detail the nature and extent of any requested Core
and Shell Changes, including, without limitation, (a) the Core and Shell Change, (b) the party required to perform the Core and Shell Change, and (c) any modification of the Final Core and Shell Plans or the Approved Core and Shell
Plans, as applicable, and the Core and Shell Work Schedule necessitated by the Core and Shell Change. If the nature of a Core and Shell Change required by Tenant requires revisions to the Final Core and Shell Plans or the Approved Core and
Shell Plans, as applicable, or the Core and Shell Work Schedule, then Tenant shall be solely responsible for the cost and expense of such revisions and all additional costs or expenses incurred by Landlord to complete the Core and Shell Work
(collectively, the “Tenant Core and Shell Costs”), which Tenant may elect to pay out of the TI Allowance. If the estimated increase in TI Costs that results from such Core and Shell Change causes the estimated TI Costs to exceed the
TI Allowance, Tenant shall deposit with Landlord the amount of such excess, as reasonably estimated by Landlord, within ten (10) days of receiving Landlord’s approval of such Core and Shell Change. 

(ii) Landlord’s Approval of Core and Shell Changes. If Landlord does not notify Tenant in writing of Landlord’s
decision either to approve or disapprove any Tenant requested Core and Shell Change within ten (10) days after receipt of a Core and Shell Tenant Change Order Request, then such Core and Shell Tenant Change Order Request shall be deemed
approved by Landlord, and Tenant shall be permitted to alter Core and Shell Work as contemplated by such Core and Shell Tenant Change Order Request. Landlord may withhold in it sole and absolute discretion its approval of any Core and Shell Tenant
Change Order Request; provided, however, Landlord shall not unreasonably withhold its approval to any Core and Shell Change requested by Tenant that is a Core and Shell Permitted Change. 

(b) Changes Requested by Landlord. 
 (i) Core and Shell Landlord Change Order Request. Tenant’s consent shall not be required in connection with Core and Shell Permitted Changes to Core and Shell Work. Other than Core and Shell
Permitted Changes, Landlord may request Core and Shell Changes to Core and Shell Work by notifying Tenant thereof in writing in substantially the same form as the AIA standard change order font! (a “Core and Shell Landlord Change Order
Request”), which Core and Shell Landlord Change Order Request shall detail the nature and extent of any requested Core and Shell Changes, including, without limitation, (a) the Core and Shell Change, (b) the party required to
perform the Core and Shell Change, and (c) any modification of the Approved Core and Shell Plans and the Core and Shell Work Schedule necessitated by the Core and Shell Change. 

(ii) Tenant’s Approval of Core and Shell Change. Tenant shall have ten (10) days after receipt of a Core and Shell
Landlord Change Order Request to notify Landlord in writing of Tenant’s approval or rejection of the Landlord-requested Core and Shell Change, which approval shall not be unreasonably withheld. Tenant’s failure to respond within such ten
(10) day period shall be deemed approval by Tenant. 

  
 G-3

 (c) Core and Shell Permitted Changes. For purposes of this Work Letter, a
“Core and Shell Permitted Change” shall mean: (a) minor field changes; (b) changes required by Governmental Authority; (c) any other changes that: (1) do not materially and adversely affect the building
structure, roof, or building service equipment to be constructed as part of Core and Shell Work, and (2) do not materially change the size, cost, configuration, or overall appearance of the Building or Landlord’s ability to construct Core
and Shell Work or Tenant’s ability to operate its business in the Building, or materially and adversely affect the Tenant Improvements or materially increase Tenant’s costs (unless such increase in cost is consented to by Tenant or
Landlord elects to pay such increased costs); and (d) ordinary development of the Approved Core and Shell Plans in a manner not inconsistent with the Approved Core and Shell Plans. 
 3. Tenant Improvements. 
 3.1 Work Plans. The Tenant Improvements,
shall be performed by Landlord at Tenant’s sole cost and expense and without cost to Landlord (except for the TI Allowance) and in accordance with the Approved TI Plans (as defined below). The design drawings, plans and specifications listed on
Exhibit C to this Work Letter (the “Tenant Work Plans”) are the initial list of plans that Tenant shall develop and submit to Landlord for approval. Tenant shall prepare and submit to Landlord for approval (such approval
not to be unreasonably withheld, conditioned or delayed) schematics covering the Tenant Improvements prepared in conformity with the applicable provisions of this Work Letter (the “Draft Plans”). The Draft Plans shall contain
sufficient information and detail to accurately describe the proposed design to Landlord and such other information as Landlord may reasonably request. Tenant shall be solely responsible for ensuring that the Tenant Work Plans and the Draft Plans
satisfy Tenant’s obligations for the Tenant Improvements. 
 3.2 Landlord Approval of Plans. Landlord shall notify
Tenant in writing within ten (10) days after receipt of the Draft Plans whether Landlord approves or objects to the Draft Plans and of the manner, if any, in which the Draft Plans are unacceptable. If Landlord reasonably objects to the Draft
Plans, then Tenant shall revise the Draft Plans and cause Landlord’s objections to be remedied in the revised Draft Plans. Tenant shall then resubmit the revised Draft Plans to Landlord for approval. Landlord’s approval of or objection to
revised Draft Plans and Tenant’s correction of the same shall be in accordance with this Section 3.2, until Landlord has approved the Draft Plans in writing. The iteration of the Draft Plans that is approved by Landlord without
objection shall be referred to herein as the “Approved Draft Plans.” 
 3.3 Design Development Plans.
Landlord shall prepare design development plans for the Tenant Improvements that: (a) are consistent with and are logical evolutions of the Approved Draft Plans, (b) incorporate TI Permitted Changes, and (c) incorporate any other
Landlord-requested TI Changes that are consented to by Tenant. As soon as such design development plans (the “Design Development Plans”) are completed, Landlord shall deliver the same to Tenant for Tenant’s approval, which
approval may be reasonably withheld only if the Design Development Plans are not consistent with or logical evolutions of the Approved Draft Plans. Such Design Development Plans 

  
 G-4

 
shall be approved or disapproved by Tenant within ten (10) days after delivery to Tenant. If Tenant fails to notify Landlord of disapproval within this ten (10) day period, the Design
Development Plans shall be deemed approved. If the Design Development Plans are disapproved by Tenant, then Tenant shall notify Landlord in writing of its objections to such Design Development Plans and the parties shall confer and negotiate in good
faith to reach agreement on the Design Development Plans. 
 3.4 Approved TI Plans. Landlord shall prepare final plans
and specifications for the Tenant Improvements that: (a) are consistent with and are logical evolutions of the Design Development Plans, (b) incorporate TI Permitted Changes, and (c) incorporate any other Landlord-requested TI Changes
to which Tenant consents. As soon as such final plans and specifications (“Final TI Plans”) are completed, Landlord shall deliver the same to Tenant for Tenant’s approval, which approval may be reasonably withheld only if:
(i) the Final TI Plans are not consistent with or logical evolutions of the Design Development Plans, or (ii) Tenant objects to any Landlord requested TI Change (other than TI Permitted Changes). Such Final TI Plans shall be approved or
disapproved by Tenant within ten (10) days after delivery to Tenant. If Tenant fails to notify Landlord of disapproval within this ten (10) day period, the Final TI Plans shall be deemed approved. If the Final TI Plans are disapproved by
Tenant, then Tenant shall notify Landlord in writing of its objections to such Final TI Plans and shall submit any requested TI Changes through a TI Tenant Change Order Request (as defined below), and the parties shall confer and negotiate in good
faith to reach agreement on the Final TI Plans. Promptly after the Final TI Plans are approved by Landlord and Tenant, two (2) copies of such Final TI Plans shall be initialed and dated by Landlord and Tenant as soon as approved by Landlord and
Tenant, Landlord shall promptly submit such Final TI Plans to all appropriate governmental agencies for approval. The Final TI Plans so approved, and all change orders specifically permitted by this Agreement, are referred to herein as the
“Approved TI Plans” and shall become part of this Lease as though set forth in full 
 3.5 Changes to Tenant
Improvements. Any changes to the Final TI Plans or the Approved TI Plans (each, a “TI Change”) requested by Landlord or Tenant (other than TI Permitted Changes made by Landlord) shall be requested and instituted in accordance
with the provisions of this Article 3 and shall be subject to the written approval of the other party in accordance with this Work Letter and the provisions of Article 44 of the Lease. 

(a) TI Changes Requested by Tenant. 
 (i) TI Tenant Change Order Request. Tenant may request TI Changes after Tenant approves the Final TI Plans or the Approved TI Plans, as applicable, by notifying Landlord thereof in writing in
substantially the same form as the AIA standard change order form (a “TI Tenant Change Order Request”), which TI Tenant Change Order Request shall detail the nature and extent of any requested TI Changes, including, without
limitation, (a) the TI Change, (b) the party required to perform the TI Change, and (c) any modification of the Final TI Plans or the Approved TI Plans, as applicable, or the respective Schedule necessitated by the TI Change. If the
nature of a TI Change requires revisions to the Final TI Plans or the Approved TI Plans, as applicable, then Tenant shall be solely responsible for the cost and expense of such revisions but 

  
 G-5

 
may apply the TI Allowance to the same. Tenant shall deposit with Landlord the additional cost and expense payable by Landlord, as reasonably estimated by Landlord, to complete the Tenant
Improvements due to a Tenant-requested TI Change within ten (10) days of receiving Landlord’s approval of such TI Change (the “TI Deposit”) if the TI Allowance is exhausted. In the event such deposit is not sufficient to
cover the approved TI Change, Tenant shall reimburse Landlord the difference between the actual cost of such TI Change and the TI Deposit. Tenant shall have the right to apply the Additional Allowance towards the TI Deposit. TI Tenant Change Order
Requests shall be signed by Tenant’s Authorized Representative. 
 (ii) Landlord’s Approval of TI Changes. All
Tenant-requested TI Changes shall be subject to Landlord’s prior written approval, which shall not be unreasonably withheld, conditioned or delayed. Landlord shall have ten (10) days after receipt of a TI Tenant Change Order Request to
notify Tenant in writing of Landlord’s approval or disapproval of any such Tenant-requested TI Change. If Landlord does not disapprove in writing a TI Tenant Change Order Request, then such TI Tenant Change Order Request shall be deemed
approved. 
 (b) TI Changes Requested by Landlord. 

(i) TI Landlord Change Order Request. Tenant’s consent shall not be required in connection with Landlord-requested TI
Permitted Changes to the Tenant Improvements. Other than TI Permitted Changes, Landlord may request TI Changes after Tenant approves the Approved TI Plans by notifying Tenant thereof in writing in substantially the same form as the AIA standard
change order form (a “TI Landlord Change Order Request”), which TI Landlord Change Order Request shall detail the nature and extent of any requested TI Changes, including, without limitation, (a) the TI Change, (b) the
party required to perform the TI Change, and (c) any modification of the Approved TI Plans or the respective Schedule necessitated by the TI Change. If the nature of a TI Change requires revisions to the Approved TI Plans, then Landlord
shall be solely responsible for the cost and expense of such revisions. 
 (ii) Tenant’s Approval of TI Change.
Tenant shall have ten (10) days after receipt of a TI Landlord Change Order Request to notify Landlord in writing of Tenant’s approval or rejection of the Landlord-requested TI Change, which approval shall not be unreasonably withheld,
conditioned or delayed. Tenant’s failure to respond within such ten (10) day period shall be deemed approval by Tenant. 
 (c) TI Permitted Changes. For purposes of this Work Letter, a “TI Permitted Change” shall mean: (a) minor field changes; (b) changes required by Governmental Authority;
(c) any other changes that: (1) do not materially and adversely affect Tenant’s requirements for the Tenant Improvements or the building structure, roof, or building service equipment to be constructed as part of the Tenant
Improvements, and (2) do not materially change the size, cost, configuration, or overall appearance of the Tenant Improvements or Tenant’s ability to operate its business in the Building or use the Premises for the Permitted Use; and
(d) ordinary development of the Approved TI Plans in a manner not inconsistent with the Approved TI Plans. In no event may Landlord make any change whatsoever to the TI Plans if the same increases Tenant’s costs, unless consented to by
Tenant. 

  
 G-6

 4. Requests for Consent. Except as otherwise provided in this Work Letter, Tenant shall respond to
all requests for consents, approvals or directions made by Landlord pursuant to this Work Letter within (10) days following Tenant’s receipt of such request. Tenant’s failure to respond within such ten (10) day period shall be
deemed approval by Tenant. 
 5. Miscellaneous. 
 5.1 Headings, Etc. Where applicable in this Work Letter, the singular includes the plural and the masculine or neuter includes the masculine, feminine and neuter. The section headings of this Work
Letter are not a part of this Work Letter and shall have no effect upon the construction or interpretation of any part hereof. 

5.2 Time of the Essence. Time is of the essence with respect to the performance of every provision of this Work Letter in which
time of performance is a factor. 
 5.3 Covenants. Each provision of this Work Letter performable by Landlord or Tenant
shall be deemed both a covenant and a condition. 
 5.4 Consent. Whenever consent or approval of either party is
required, that party shall not unreasonably withhold such consent or approval, except as may be expressly set forth to the contrary. 
 5.5 Entire Agreement. The terms of this Work Letter are intended by the parties as a final expression of their agreement with respect to the terms as are included herein, and may not be
contradicted by evidence of any prior or contemporaneous agreement, other than the Lease. 
 5.6 Invalid Provisions. Any
provision of this Work Letter that shall prove to be invalid, void or illegal shall in no way affect, impair or invalidate any other provision hereof, and all other provisions of this Work Letter shall remain in full force and effect and shall be
interpreted as if the invalid, void or illegal provision did not exist. 
 5.7 Construction. The language in all parts of
this Work Letter shall be in all cases construed as a whole according to its fair meaning and not strictly for or against either Landlord or Tenant. 
 5.8 Assigns. Each of the covenants, conditions and agreements herein contained shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs;
legatees; devisees; executors; administrators; and permitted successors, assigns, sublessees. Nothing in this Section 5.8 shall in any way alter the provisions of the Lease restricting assignment or subletting. 

5.9 Authority. Each of Tenant and Landlord warrant that the individual or individuals signing this Work Letter on its behalf have
the power, authority and legal capacity to sign this Work Letter on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers or other organizations and entities on whose behalf said individual or
individuals have signed. 

  
 G-7

 5.10 Counterparts. This Work Letter may be executed in one or more counterparts, each
of which, when taken together, shall constitute one and the same document. 
 IN WITNESS WHEREOF, Landlord and Tenant have
executed this Work Letter to be effective on the date first above written. 
  

			
	LANDLORD:
	
	 BMR-530 FAIRVIEW AVENUE LLC,
 a Delaware limited liability company

		
	By:	 	  

	Name:	 	  

	Title:	 	  

	
	TENANT:
	
	 NANOSTRING TECHNOLOGIES, INC.,
 a Delaware corporation

		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 G-8

 EXHIBIT A-1 
 CORE AND SHELL WORK SCHEDULE 
  
 

 

 EXHIBIT A-2 
 TENANT IMPROVEMENTS SCHEDULE 
  
 

 

 EXHIBIT B 
 PLANS AND SPECIFICATIONS 
 The Contract Documents include the following: 

Geotechnical Report: 

Geotechnical Report by Terra Associates dated November 7, 2005 
 Specifications: 
 Fairview Research Center Project Manual dated 9/22/06 

 
 

 

 

 

 

 

  
 

 

  
 

 

 EXHIBIT C 
 TENANT WORK PLANS 
 Tenant shall provide a full set of design
drawings, plans and specifications as reasonably required by Landlord. 

 EXHIBIT H 
 FORM OF LETTER OF CREDIT 
 [On letterhead or L/C letterhead of
Issuer.] 
 LETTER OF CREDIT 
 Date:             , 200     
  

					
	  
	  	(the “Beneficiary”)
	  
	  	
	  
	  	
	Attention:	 	  
	  	
	L/C. No.:	 	  
	  	
	Loan No. :	 	  
	  	

 Ladies and Gentlemen: 
 We establish in favor of Beneficiary our irrevocable and unconditional Letter of Credit numbered as identified above (the “L/C”) for an aggregate amount of
$        , expiring at     :00 p.m. on          or, if such day is not a Banking Day, then the next succeeding Banking Day (such date, as extended
from time to time, the “Expiry Date”). “Banking Day” means a weekday except a weekday when commercial banks in              are authorized or required to
close. 
 We authorize Beneficiary to draw on us (the “Issuer”) for the account of
             (the “Account Party”), under the terms and conditions of this L/C. 
 Funds under this L/C are available by presenting the following documentation (the “Drawing Documentation”): (a) the original L/C and (b) a sight draft substantially in the form
of Exhibit A, with blanks filled in and bracketed items provided as appropriate. No other evidence of authority, certificate, or documentation is required. 
 Drawing Documentation must be presented at Issuer’s office at                      on or before the
Expiry Date by personal presentation, courier or messenger service, or fax. Presentation by fax shall be effective upon electronic confirmation of transmission as evidenced by a printed report from the sender’s fax machine. After any fax
presentation, but not as a condition to its effectiveness, Beneficiary shall with reasonable promptness deliver the original Drawing Documentation by any other means. Issuer will on request issue a receipt for Drawing Documentation. 

We agree, irrevocably, and irrespective of any claim by any other person, to honor drafts drawn under and in conformity with this L/C,
within the maximum amount of this L/C, presented to us on or before the Expiry Date, provided we also receive (on or before the Expiry Date) any other Drawing Documentation this L/C requires. 

  
 H-1

 We shall pay this L/C only from our own funds by check or wire transfer, in compliance with
the Drawing Documentation. 
 If Beneficiary presents proper Drawing Documentation to us on or before the Expiry Date, then we
shall pay under this L/C at or before the following time (the “Payment Deadline”): (a) if presentment is made at or before noon of any Banking Day, then the close of such Banking Day; and (b) otherwise, the close of the
next Banking Day. We waive any right to delay payment beyond the Payment Deadline. If we determine that Drawing Documentation is not proper, then we shall so advise Beneficiary in writing, specifying all grounds for our determination, within one
Banking Day after the Payment Deadline. 
 Partial drawings are permitted. This L/C shall, except to the extent reduced thereby,
survive any partial drawings. 
 We shall have no duty or right to inquire into the validity of or basis for any draw under this
L/C or any Drawing Documentation. 
 The Expiry Date shall automatically be extended by one year (but never beyond
             the “Outside Date”) unless, on or before the date sixty (60) days before any Expiry Date, we have given Beneficiary notice that the Expiry Date shall not
be so extended (a “Nonrenewal Notice”). We shall promptly upon request confirm any extension of the Expiry Date under the preceding sentence by issuing an amendment to this L/C, but such an amendment is not required for the
extension to be effective. We need not give any notice of the Outside Date. 
 Beneficiary may from time to time without charge
transfer this L/C, in whole but not in part, to any transferee (the “Transferee”). Issuer shall look solely to Account Party for payment of any fee for any transfer of this L/C. Such payment is not a condition to any such transfer.
Beneficiary or Transferee shall consummate such transfer by delivering to Issuer the original of this L/C and a Transfer Notice substantially in the form of Exhibit B, purportedly signed by Beneficiary, and designating Transferee. Issuer
shall promptly reissue or amend this L/C in favor of Transferee as Beneficiary. Upon any transfer, all references to Beneficiary shall automatically refer to Transferee, who may then exercise all rights of Beneficiary. Issuer expressly consents to
any transfers made from time to time in compliance with this paragraph. 
 Any notice to Beneficiary shall be in writing and
delivered by hand with receipt acknowledged or by overnight delivery service such as FedEx (with proof of delivery) at the above address, or such other address as Beneficiary may specify by written notice to Issuer. A copy of any such notice shall
also be delivered, as a condition to the effectiveness of such notice, to:              (or such replacement as Beneficiary designates from time to time by written notice). 

No amendment that adversely affects Beneficiary shall be effective without Beneficiary’s written consent. 

  
 H-2

 This L/C is subject to and incorporates by reference: (a) the Uniform Customs and
Practice for Documentary Credits, International Chamber of Commerce Publication No. 500 (the “UCP”); and (b) to the extent not inconsistent with the UCP, Article 5 of the Uniform Commercial Code of the State of
New York. 
  

	
	Very truly yours,
	
	[Issuer Signature]

  
 H-3

 EXHIBIT A 
 FORM OF SIGHT DRAFT 
 [BENEFICIARY LETTERHEAD] 

TO: 
 [Name and Address of Issuer] 

SIGHT DRAFT 
 AT SIGHT,
pay to the Order of                     , the sum of
                     United States Dollars ($        ). Drawn under [Issuer] Letter of Credit No.
         dated                     . 
 [Issuer is hereby directed to pay the proceeds of this Sight Draft solely to the following account:
                            -] 
 [Name and signature block, with signature or purported signature of Beneficiary] 
  

			
	Date:	 	  

  
 H-4

 EXHIBIT B 
 FORM OF TRANSFER NOTICE 
 [BENEFICIARY LETTERHEAD] 

TO: 
 [Name and Address of Issuer] (the
“Issuer”) 
 TRANSFER NOTICE 
 By signing below, the undersigned, Beneficiary (the “Beneficiary”) under Issuer’s Letter of Credit No.          dated
                     (the “L/C”), transfers the L/C to the following transferee (the “Transferee”): 

[Transferee Name and Address] 
 The original
L/C is enclosed. Beneficiary directs Issuer to reissue or amend the L/C in favor of Transferee as Beneficiary. Beneficiary represents and warrants that Beneficiary has not transferred, assigned, or encumbered the L/C or any interest in the L/C,
which transfer, assignment, or encumbrance remains in effect. 
 [Name and signature block, with signature or purported signature of
Beneficiary] 
  

			
	Date:	 	  

  
 H-5

 EXHIBIT I 
 FORM OF ADDITIONAL TI ALLOWANCE ACCEPTANCE LETTER 
 [TENANT
LETTERHEAD] 
 BMR-530 Fairview Avenue LLC 
 17140 Bernardo Center Drive, Suite 222 
 San Diego, California 92128 

Attn: General Counsel/Real Estate 

[Date] 
 Re:
Additional Allowance 
 To Whom It May Concern: 
 This letter concerns that certain Lease dated as of October 19, 2007 (the “Lease”), between BMR-530 FAIRVIEW AVENUE LLC (“Landlord”) and NANOSTRING TECHNOLOGIES,
INC., (“Tenant”). Capitalized terms not otherwise defined herein shall have the meanings given them in the Lease. 
 Tenant hereby notifies Landlord that it wishes to exercise its right to utilize $         of the Additional Allowance pursuant to Section 4.2.3 of the
Lease. 
 If you have any questions, please do not hesitate to call
[            ] at ([            ])
[            ]-[            ] 

 

	
	Sincerely,
	
	[Name]
	[Title of Authorized Signatory]

  

			
	Cc:	 	Greg Lubushkin
		 	John Wilson
		 	Kevin Simonsen

  
 I-1

 EXHIBIT J 

FORM OF HOLDOVER SIDE LETTER 

  
 J-1

 BMR-201 Elliott Avenue LLC 

17140 Bernardo Center Drive, Suite 222 
 San Diego, California 92128 
 Phone: (858) 485-9840 

Facsimile: (858) 485-9843 
 October 19, 2007 
 Nanostring Technologies, Inc. 

201 Elliott Ave, W. Suite 300 
 Seattle,
Washington 98119 
 Attn: Wayne Burns 
 Re: Leases for Fairview Research Center and 201 Elliott Avenue 
 Dear Mr. Burns:

 This letter agreement is written in connection with (a) that certain lease dated as of the date hereof for the building
to be constructed at 530 Fairview Avenue, Seattle, Washington (the “New Building Lease”) by and between BMR-530 Fairview Avenue LLC, as landlord (“Landlord”), and Nanostring Technologies, Inc., as tenant (“Tenant”),
(b) that certain Lease Agreement (the “Existing Master Lease”) dated August 20, 2002 by and between BMR¬201 Elliott Avenue LLC (successor-in-interest to Elliott Park LLC), as landlord (“Master Landlord”) and Cell
Therapeutics, Inc., as tenant (“Cell Therapeutics”), and (c) that certain Sublease (the “Existing Sublease”) dated as of October 6, 2004, as amended, and Service Agreement (“Service Agreement) with an effective
date of October 15, 2004, both by and between Cell Therapeutics, as sublessor, and Tenant, as sublessee. 
 Master Landlord
currently leases certain space on the first, third, fourth and fifth floors of the building (the “Building”) located at 201 Elliott Avenue, W. Suite 300, Seattle, Washington (the “Master Leased Premises”) to Cell Therapeutics
pursuant to the Master Lease, and Cell Therapeutics currently subleases a certain portion of the Master Leased Premises located on the third floor of such building (the “Existing Premises”) to Nanostring Technologies, Inc. pursuant to the
Existing Sublease. Pursuant to the Existing Master Lease and the Existing Sublease, the Existing Master Lease and the Existing Sublease will expire on January 31, 2008 (the “Existing Lease Expiration Date”). 

Notwithstanding the foregoing, and in consideration of Tenant’s entering into the New Building Lease (Master Landlord acknowledges
that it will receive a direct or indirect benefit from Tenant’s entering into the New Building Lease), Master Landlord shall permit Tenant to continue to occupy and use the Existing Premises for the time period (such time period being referred
to herein as the “Gap Period”) beginning on the Existing Lease Expiration Date and ending on the “Term Commencement Date” (as such term is defined in, and may be adjusted under, the New Building Lease) on the same terms and
conditions as the Existing Sublease (as if the Existing Sublease were a direct lease between Tenant and Master Landlord); provided, however, that Tenant shall not be 

 
obligated to pay any Base Rent (as such term is defined in the Existing Sublease) for the Gap Period; provided, further, if the New Building Lease terminates before the Term Commencement Date,
then Tenant’s right to occupy the Existing Premises shall terminate effective on the later of (a) fifteen days after the New Building Lease terminates or (b) the Existing Lease Expiration Date; provided that if such termination is
primarily due to Landlord’s default or breach of the New Building Lease, then such right of Tenant to occupy the Existing Premises shall terminate on the date that is twelve (12) months after the date of termination of the New Building
Lease. For the avoidance of doubt, the parties agree that Tenant shall remain obligated during the Gap Period to perform the following obligations, among other obligations, as set forth in the Sublease (except that such obligations shall be
performed for the benefit of Master Landlord rather than Cell Therapeutics): (i) to pay Tenant’s pro rata share of all Taxes and Operating Costs (as such terms are defined in the Existing Sublease) for the Existing Premises (with the
exception of any Taxes or Operating Costs for the Existing Premises directly or indirectly and primarily attributable to Master Landlord’s planned improvements to the Existing Premises) as required by Section 2.3 of the Existing Sublease
during the Gap Period (except that Tenant should pay such amounts to Landlord rather than Cell Therapeutics), (ii) to maintain the insurance required by Section 5.4 of the Existing Sublease and (iii) to satisfy any other obligations
under the Existing Sublease related to Tenant’s occupancy of the Existing Premises during the Gap Period. Similarly, during the Gap Period, Master Landlord shall continue to provide for the benefit of Tenant rather than Cell Therapeutics all
services that Master Landlord is required to provide to Cell Therapeutics under the Existing Master Lease with respect to the Existing Premises (as if the time of the Master Lease were extended for the Gap Period), and Tenant shall enjoy and be
entitled to all of the benefits and rights to which Cell Therapeutics is entitled under the Existing Master Lease (as if the term of the Master Lease were extended for the Gap Period), including without limitation (i) all rights and protections
benefiting the tenant under Section 6 of the Existing Master Lease; (ii) all services and utilities as required by Section 7 of the Existing Master Lease (including without limitation the provision of electrical, water, HVAC,
janitorial and security services), (iii) the audit right set forth in Section 8.4 of the Existing Master Lease, (iv) the waiver of subrogation set forth in Section 12 of the Existing Master Lease, (v) the indemnification
provisions of Section 13 of the Existing Master Lease, (vi) the default and remedy provisions of Section 19.10 of the Existing Master Lease, and (vii) parking spaces as required by Section 29 of the Existing Master Lease.

 The parties further understand, agree and acknowledge that Master Landlord may make certain improvements to the Building
(other than the Existing Premises) during the Gap Period (the “Improvements”), and that the nature of the Improvements may interfere with Tenant’s use of the Existing Premises as permitted by the terms of the Existing Sublease,
including through the introduction of noise, vibration and dirt into the Existing Premises; provided, however, Master Landlord shall not unnecessarily disturb Tenant’s access to the Existing Premises. Tenant knowingly and
voluntarily assumes the risk of, and agrees that Master Landlord shall not be liable to Tenant for, any consequential or other damages arising in connection with the Improvements, and Tenant further waives any claim for injury, loss of income or
other damages relating to the Improvements. Landlord will endeavor to keep Tenant informed of the progress of the Improvements to the extent they may interfere with Landlord’s operations and to reasonably cooperate with Tenant to avoid
unnecessary disruption to Tenant’s operations. 

 So long as Tenant is not in default beyond applicable notice and cure periods under the
Existing Sublease, Tenant’s peaceable and quiet enjoyment of the Existing Premises shall not be disturbed by Master Landlord or anyone claiming by or through Master Landlord. 

Notwithstanding anything to the contrary, upon the expiration of the Gap Period, Tenant shall surrender the Existing Premises to Landlord
in its as-is condition, without any obligation to remove or restore any improvements or alterations to the Existing Premises. Tenant shall be entitled to remove any equipment, fixtures or trade fixtures from the Existing Premises at Tenant’s
election. At least ten (10) days prior to Tenant’s surrender of possession of the Existing Premises, Tenant shall provide Landlord with a facility decommissioning report for the Existing Premises (“Exit Survey”) in order to
verify that Tenant has left the Existing Premises free of environmental conditions in violation of applicable laws. Tenant agrees to remain responsible after the surrender of the Existing Premises for the remediation of any environmental conditions
in the Existing Premises in violation of law that are set forth in the Exit Survey as well as compliance with any reasonable recommendations set forth in the Exit Survey. However, notwithstanding the foregoing, Tenant shall not be responsible for
environmental conditions in the Existing Premises that were not caused by Tenant or Tenant’s agents, contractors or employees. Tenant’s obligations under this paragraph shall survive the expiration or earlier termination of the New
Building Lease or this letter agreement. 
 If legal proceedings are initiated to enforce any term of this letter agreement or
for the breach of any covenant or condition of this letter agreement, the prevailing party shall be entitled to recover reasonable attorneys’ fees and costs of suit to be fixed by the court. 

Please cause an authorized representative of Tenant to execute this Letter Agreement in the place provided below to indicate
Tenant’s agreement with the terms and conditions set forth herein. 
  

			
	Very truly yours,
	
	 BMR-201 ELLIOTT AVENUE LLC,
 a Delaware limited liability, company

		
	By:	 	 /s/ Kent Griffin

	Name:	 	 Kent Griffin

	Title:	 	 CFO

  

			
	ACCEPTED AND AGREED:
	
	 NANOSTRING TECHNOLOGIES, INC.
 a Delaware corporation

		
	By:	 	 /s/ Wayne Burns

	Name:	 	 Wayne Burns

	Title:	 	 CFO

  

			
	cc:	 	Steven Levine, Esq.
		 	Kevin Simonsen
		 	Chris Elmendorf

 EXHIBIT K 

[INTENTIONALLY DELETED] 

 EXHIBIT L 

WARM SHELL WORK 
  

	
	 Roofing

	Miscellaneous roofing as needed
	Walkway pads to base building mechanical equipment
	 Common Areas

	Finished first floor lobby
	Parking level 1 restroom/shower and janitor closet
	Finished exit stairways
	 Tenant Areas

	Rated shafts per plans
	 Plumbing

	Sanitary waste system and risers tee’d and capped at each floor
	Domestic water distribution - a domestic water riser will be provided with a T connection that will be valved and capped to each floor
	Lab water distribution - Lab hot and cold water systems will be provided with a T connection that will be valved and capped to each floor.
	 Gas

	Gas riser to penthouse
	 H.V.A.C

	Central HVAC system providing 100% outside air for tenant use. A base design of 1 CFM/sf to support lab or office use is available to each floor.
	Exhaust capacity for common areas & toilets per code
	Exhaust capacity for office and lab
	Supply and exhaust duct risers provided
	Hydronic systems - Hot and cold hydronic connections will be provided with a T connection that will be valved and capped to each floor.
	Automatic temperature control system - Building Management System is installed for the base building systems
	Network communication riser provided for tenant access to Building Management System
	 Electrical

	400 amp 480/277 Volt panel is provided on each floor.
	Electrical closets on tenant floors
	A central fire alarm system is provided with a connection J-box at each floor for tenant use
	Empty telephone/data conduits from telecom room distributed to each floor
	 Security

	Card access at bldg entries and w/in elevators, and stairwells
	Security system for base bldg area

 Many of the warm shell improvements identified above are illustrated in the sets of plans from Mithun Architects,
entitled Warm Shell Revision dated August 6, 2007. Tenant shall have access to said plans upon request. 
 Landlord may include other
improvements (“Warm Shell Additions”), not described above, in the Warm Shell Work, so long as the Warm Shell Additions are (i) of common service to all floors in the building and (ii) do not exceed, in the aggregate, a cost of
$5.00 per rentable square foot of the building.

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