Document:

DC6882.pdf -- Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing

INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT

     THIS INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT (this “Assignment”) is made and dated as of June 2, 2009 (the “Effective Date”) by and between CombinatoRx, Incorporated, a Delaware corporation with its principal office and place of business at 245 1st Street, Cambridge, MA 02142 (“CRX”), and ExCRX Singapore Pte. Ltd., formerly known as CombinatoRx (Singapore) Pte Ltd, a company incorporated in Singapore with company registration number 200511269N whose registered office is
11 Biopolis Way #08-05/06 Helios Singapore 138667 (“CRX-SG”).

     WHEREAS, CRX and CRX-SG have entered into a Termination Agreement of even date herewith, pursuant to which the Services Agreement between CRX and CRX-SG, dated as of August 19, 2005 (the
“Prior Services Agreement”) has been terminated; and

     WHEREAS, CRX and CRX-SG have entered into a Transition Services Agreement of even date herewith (the “Transition Services Agreement”), pursuant to which CRX agrees to transition services previously performed by CRX to third parties designated by CRX-SG to perform such services; and

     WHEREAS, CRX and CRX-SG wish to confirm their understanding regarding certain intellectual property rights.

     NOW THEREFORE, be it known that, for good and valuable consideration, receipt of which is hereby acknowledged, the Parties agree as follows:

	
1. Definitions.

“Agreement IP Rights” shall mean the Project Intellectual Property and the Previously Assigned Patent Rights.

“CRX Technology” shall mean all inventions, discoveries, technologies, trade secrets, works of authorship, writings, data and other information (i) that were owned by CRX prior to the
conduct or commencement of any services pursuant to the Prior Services Agreement, or which were developed or acquired by CRX independently of, and not in the performance of services pursuant to the Prior Services Agreement or (ii) that were
developed or acquired by CRX in the performance of services pursuant to the Prior Services Agreement and that do not relate to novel therapeutic combinations for Infectious Disease.

“Infectious Disease” shall mean any disease indication caused by a viral, bacterial or fungal infection, other than any disease indication which may be related to or caused by a viral,
bacterial or fungal infection, or which may have a putative infectious component, but primary treatment for which, as of the initiation of research or development work on such indication by CRX, is not typically anti-infective in nature, including,
without 

limitation or by way of example, such indications as cervical cancer (possibly caused by HPV) or Crohn’s disease (putative cause: infections).

“Previously Assigned Patent Rights” shall mean all right, title and interest in and to any U.S. Patent Applications listed on Exhibit A, any invention claimed therein, any other patent application directed to any such invention, and all Letters Patent of the United States that may be granted thereon, and all reissues, continuations, continuations-in-part, divisions,
revisions, reexaminations, and extensions thereof; and all rights to claim priority on the basis of such applications, and all applications for Letters Patent that have been or may be filed for any such invention in any country of the world and all
Letters Patent that may be granted on any such invention in any country of the world, and all extensions, renewals, and reissues thereof, constituting all patent rights made or developed pursuant to the Prior Services Agreement that have, pursuant
to the provisions thereof, previously been assigned by CRX to CRX-SG.

“Project Intellectual Property” shall mean any and all data, writings (irrespective of whether in written or electronic form), information (tangible and intangible), processes, methods,
inventions, discoveries, improvements, trade secrets, works of authorship and technology in any form whatsoever, and any and all patent, copyright and other intellectual property rights therein, resulting from or generated, made or developed by or
on behalf of CRX in the performance of the services provided to CRX-SG under the Prior Services Agreement to the extent any of the foregoing covers novel therapeutic combination therapies for Infectious Disease, but excluding, without limitation,
any process, methods, inventions, discoveries, improvements, trade secrets, works of authorship and technology related solely to the CRX Technology.

2. Ownership and Assignment of Patent Rights.

CRX and CRX-SG hereby agree that the Previously Assigned Patent Rights listed on Exhibit A are owned by and vest solely and exclusively in CRX-SG under the terms of the
Prior Services Agreement. Without prejudice to the foregoing, CRX hereby transfers and assigns to CRX-SG:

	
a.      		
all rights, title and interests, including all intellectual property rights anywhere in the world, whether registered or not, and all benefits and rights to sue or obtain relief for any past, current or future infringement or
violation of such rights, in and to the Agreement IP Rights throughout all countries of the world and in perpetuity; and	
	 
	
b.      		
all rights of action, powers and benefits arising from ownership of the Agreement IP Rights throughout all countries of the world and in perpetuity, including without limitation, the right to sue for damages and other legal and
equitable remedies in respect of all causes of action arising prior to, on or after the Effective Date.	
	 

CRX hereby authorizes and requests the Commissioner of Patents and Trademarks of the United States and any official of any country of the world whose duty it is to issue patents on applications as described above, to issue all
Letters Patent for the invention(s) to CRX-SG or its lawful successors or assigns, in accordance with the terms of this Assignment.

To the extent that any rights, title and interests, including all intellectual property rights anywhere in the world, whether registered or not, and all benefits and rights to sue or obtain relief for any past, current or future
infringement or violation of such rights, in and to the Agreement IP Rights (or any part thereof) in any country of the world may remain or become vested in CRX or its related corporations notwithstanding Section 2, CRX shall and hereby agrees, at
CRX-SG’s prior written request and at CRX-SG’s expense, to irrevocably assign, transfer and convey and/or undertake to procure that such related corporations shall irrevocably assign, transfer and convey, absolutely and unconditionally, to
CRX-SG, the said rights, title and interests by way of agreement in a form substantially similar to this Assignment. 

CRX agrees and confirms that no sums, royalties, payments and/or other charges of any kind shall be payable by CRX-SG to CRX or any of its related corporations under this Assignment for the assignment and conveyance of the
Agreement IP Rights. 

CRX confirms that the assignment set out in Section 2 includes the assignment of all the benefits of all patent and design applications, in any country of the world, comprised in the Agreement IP Rights and the assignment of all
intellectual property rights in and to the inventions and subject matter of patents, in all countries of the world, comprised in the Agreement IP Rights.

3. Confirmation of Rights. For the avoidance of doubt, (i) the Previously Assigned 

Patent Rights listed on Exhibit A and the subject matter listed on Exhibit B comprise substantially all of the
Agreement IP Rights, (ii) except as expressly provided in this Assignment with respect to the Agreement IP Rights, CRX-SG has no right or interest in or under any intellectual property now or previously owned or controlled by CRX other than the
Agreement IP Rights and all CRX Technology shall remain the sole and exclusive property of CRX and (iii) CRX has no right or interest in or under any intellectual property of CRX-SG currently filed or filed by CRX-SG in the future, and all Agreement
IP Rights shall remain the sole and exclusive property of CRX-SG. 

CRX shall promptly discontinue all use of the Project Intellectual Property in any form or manner. CRX hereby represents, warrants and undertakes with CRX-SG that CRX has not (i) granted any third party any right, licence or
sub-licence to use the Project Intellectual Property in any manner or (ii) permitted any third party to use or exploit the Project Intellectual Property, except the agreements by and among CRX and CRX-SG with the Liverpool School of Tropical
Medicine relating to the A-WOL Consortium, which are terminating with respect to CRX as of the Effective Date.

	
4.      		
Perfection, Assistance and Recordal.	
	 
	 	
a.      		
At CRX-SG’s prior written request and at CRX-SG’s expense, CRX undertakes to do any and all acts and execute any and all documents in such manner and at such location as may be required by CRX-SG in CRX-SG’s
discretion to: (i) protect, perfect or enforce any of the rights, privileges and entitlements granted or promised to CRX-SG by this Assignment; and (ii) enable CRX-SG to pursue or prosecute any application in respect of the Agreement IP Rights to
registration in favour of CRX-SG or such other party as CRX-SG may direct. For the purposes of the provisions above and without prejudice to its generality, CRX hereby undertakes at the request of CRX-SG to sign and execute such formal assignment
documents as may be required by the relevant registries anywhere in the world, in the form required by such registry and/or substantially in the form as set out in Exhibit D.	
	 
	 	
b.      		
CRX undertakes to reasonably cooperate with CRX-SG in any proceedings for infringement of any Agreement IP Rights, including providing such information as CRX-SG may reasonably request, provided that CRX-SG shall reimburse any
costs or expenses incurred by CRX in providing such cooperation.	
	 
	 	
c.      		
CRX hereby authorises the recordal of this Assignment with the relevant patent or other Intellectual Property Rights registries anywhere in the world by agents appointed by CRX-SG.	
	 
	 	
d.      		
As security for the performance by CRX of its obligations under this Agreement, if CRX shall have failed following 14 days' notice from CRX-SG to perform any act or execute any document referred to in this Section 4, CRX-SG shall
have the right to do so in the place and stead of CRX as the lawfully appointed attorney of CRX and CRX undertakes to confirm and ratify and be bound by any and all of the actions of CRX-SG pursuant to this Clause and such authority and appointment
shall take effect as an irrevocable appointment.	
	 
	 	
e.      		
CRX shall furnish, deliver, divulge, transfer, disclose, impart or otherwise communicate to CRX-SG, the Delivery Materials in its possession, where “Delivery Materials” means the most up-to-date and complete data, media,
documents, reports and shall be deemed to include the materials listed in Exhibit C.	
	 
	
5.      		
Disclaimers.	
	 
	 	
a.      		
EACH PARTY PROVIDES OR HAS PROVIDED THE	
	 
	 	 	
AGREEMENT IP RIGHTS, ON AN “AS IS” BASIS, WITHOUT	
	 

	 	
ANY WARRANTY WHATSOEVER, AND HEREBY DISCLAIMS ALL WARRANTIES, EXPRESS, IMPLIED, STATUTORY OR ARISING FROM CUSTOM OR TRADE, INCLUDING WITHOUT LIMITATION THE IMPLIED WARRANTIES OF	
	 
	 	
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NON-INFRINGEMENT. EACH PARTY UNDERSTANDS AND AGREES THAT THE AGREEMENT IP RIGHTS MAY BE INCORRECT OR INCOMPLETE AND MAY HAVE DEFECTS, AND THAT THE ASSIGNING OR GRANTING PARTY
SHALL HAVE NO LIABILITY TO THE RECEIVING PARTY OR ANY THIRD PARTY IN CONNECTION THEREWITH.	
	 
	 	
b.      		
NEITHER PARTY SHALL BE LIABLE FOR ANY INDIRECT, SPECIAL, INCIDENTAL, CONSEQUENTIAL OR EXEMPLARY	
	 
	 	 	
DAMAGES ARISING UNDER OR OUT OF THE ASSIGNMENT HEREUNDER, REGARDLESS OF WHETHER ADVISED BEFOREHAND OF THE POSSIBILITY OF SUCH DAMAGES.	
	 
	
6.      		
Prosecution, Maintenance and Enforcement of Agreement IP Rights	
	 
	 	
a.      		
Prosecution and Maintenance. CRX-SG shall have the sole right, but not the obligation, to prepare, file, prosecute and maintain any patent right included in the Agreement IP Rights throughout the
world at CRX-SG’s expense.	
	 
	 	
b.      		
Enforcement of Agreement IP Rights. CRX-SG shall have the exclusive right but not the obligation, at CRX-SG’s sole cost and expense, to take action to obtain a discontinuance of infringement
or bring suit or otherwise to take appropriate action with respect to any alleged, actual or threatened infringement or other improper use of any Agreement IP Rights. At the reasonable request of CRX-SG, CRX shall render to CRX-SG reasonable
cooperation in respect of such actions at CRX-SG’s expense.	
	 
	
7.      		
Miscellaneous.	
	 
	 	
a.      		
This Assignment shall be governed in all respects by the laws of the Commonwealth of Massachusetts without regard to conflicts of law principles.	
	 
	 	
b.      		
In the event any proceeding or lawsuit is brought by either party in connection with this Assignment, each party shall bear its own attorneys’ fees and costs.	
	 

	
c.      		
The failure of either party to require performance by the other party of any provision hereof shall not affect the full right to require such performance at any time thereafter, nor shall the waiver by either party of a breach of
any provision hereof be taken or held to be a waiver of the provision itself.	
	 
	
d.      		
Each of the Parties will promptly do, make, execute or deliver, or cause to be done, made, executed or delivered, all further acts, documents and things as the other Party may reasonably require from time to time for the purpose
of giving effect to this Assignment and will use reasonable efforts and take all steps as may be reasonably within its power to implement to their full extent the provisions of this Assignment.	
	 
	
e.      		
In the event that any provision of this Assignment shall be unenforceable or invalid under any applicable law or be so held by applicable court decision, such unenforceability or invalidity shall not render this Assignment
unenforceable or invalid as a whole, and, in such event, such provision shall be changed and interpreted so as to best accomplish the objectives of such unenforceable or invalid provision within the limits of applicable law or applicable court
decisions.	
	 
	
f.      		
This Assignment will be binding upon and inure to the benefit of the parties and their successors and assigns.	
	 
	
g.      		
This Assignment may be executed simultaneously in two (2) or more counterparts, each of which shall be considered an original, but all of which together shall constitute one and the same instrument.	
	 
	
h.      		
This Assignment together with the exhibit hereto completely and exclusively states the agreement of the parties regarding its subject matter. This Assignment supersedes, and its terms govern, all prior proposals, agreements, or
other communications between the parties, oral or written, regarding such subject matter, including the Prior Services Agreement. This Assignment shall not be modified except by a subsequently dated written amendment signed by both parties. Any
purported oral amendment to this Assignment shall have no effect.	
	 

     IN WITNESS WHEREOF, each party has caused this Assignment to be executed in its name by its duly authorized representative.

	
CRX: 
		
 		
 
		
 		
CRX-SG: 
	
	
COMBINATORX, INCORPORATED 
		
 		
ExCRX Singapore Pte. Ltd. 
	
	
 
		
 		
 
		
 		
(f.k.a. COMBINATORX (SINGAPORE) 
	
	
 
		
 		
 
		
 		
PTE LTD) 
	
	
By /s/ Robert Forrester 
		
 		
By /s/ Yeo Su Ling 
	
	
Name: Robert Forrester 
		
 		
Name: Yeo Su Ling 
	
	
Title: 
		
 		
EVP and CFO 
		
 		
Title: 
		
 		
Director 
	
	
Date: 
		
 		
June 2, 2009 
		
 		
Date: 
		
 		
June 2, 2009 
	

	
Exhibit A

Previously Assigned Patent Rights

	
Exhibit B

Project Intellectual Property Rights

Exhibit C

Delivery Materials

Exhibit D

Form AssignmentDC6888.pdf -- Converted by SEC Publisher 4.2, created by BCL Technologies Inc., for SEC Filing

TRANSITION SERVICES AGREEMENT

BY AND BETWEEN

COMBINATORX, INCORPORATED

AND

EXCRX SINGAPORE PTE. LTD.

(f.k.a. COMBINATORX (SINGAPORE) PTE. LTD.)

	
DATED JUNE 2 2009

	
TABLE OF CONTENTS
	
	
 
		
 		
 
		
 		
Page 
	
	
1. 
		
 		
GENERAL SCOPE OF AGREEMENT 
		
 		
1 
	
	
2. 
		
 		
RESPONSIBILITIES 
		
 		
1 
	
	
3. 
		
 		
SUBCONTRACTING 
		
 		
2 
	
	
4. 
		
 		
CHANGES IN SCOPE 
		
 		
2 
	
	
5. 
		
 		
TERM 
		
 		
2 
	
	
6. 
		
 		
PAYMENTS AND SCHEDULES 
		
 		
2 
	
	
7. 
		
 		
NOTICES 
		
 		
3 
	
	
8. 
		
 		
INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT 
		
 		
3 
	
	
9. 
		
 		
CONFIDENTIAL INFORMATION 
		
 		
3 
	
	
10. 
		
 		
PUBLICITY; DISCLOSURE 
		
 		
4 
	
	
11. 
		
 		
PURCHASER REPORTING 
		
 		
4 
	
	
12. 
		
 		
INDEMNIFICATION 
		
 		
4 
	
	
13. 
		
 		
INSURANCE 
		
 		
5 
	
	
14. 
		
 		
TERMINATION 
		
 		
5 
	
	
15. 
		
 		
CONFORMANCE WITH LAW; REPRESENTATION 
		
 		
6 
	
	
16. 
		
 		
APPLICABLE LAW 
		
 		
6 
	
	
17. 
		
 		
INDEPENDENT CONTRACTOR 
		
 		
6 
	
	
18. 
		
 		
ENTIRE AGREEMENT 
		
 		
6 
	
	
19. 
		
 		
ASSIGNMENT 
		
 		
7 
	
	
20. 
		
 		
WAIVER 
		
 		
7 
	
	
21. 
		
 		
FORCE MAJEURE 
		
 		
7 
	
	
22. 
		
 		
MISCELLANEOUS 
		
 		
7 
	

	
TRANSITION SERVICES AGREEMENT

This Transition Services Agreement (the “Agreement”) is made and dated as of as of June 2, 2009 (the “Effective
Date”) by and between CombinatoRx, Incorporated, a Delaware corporation with its principal office and place of business at 245 1st Street, Cambridge, MA 02142 (“Provider”), and ExCRX Singapore Pte. Ltd., formerly known as CombinatoRx (Singapore) Pte. Ltd., a Singapore private limited company (the “Purchaser”).

	
The parties agree as follows.

1. GENERAL SCOPE OF AGREEMENT

A. This Agreement relates to the termination of services formerly provided by Provider to Purchaser as Provider’s majority-owned subsidiary, and pursuant to the Services Agreement between the Provider and CombinatoRx
(Singapore) Pte. Ltd., dated as of August 19, 2005 (the “Prior Agreement”), and to the transition of the performance of such services to Purchaser or third parties designated by
Purchaser.

B. The scope of the work to be performed under this Agreement, which shall consist of the transition of certain services provided to Purchaser to Purchaser or third parties designated by Purchaser, shall be negotiated and set
forth in a writing on terms reasonably acceptable to both parties and in substantially the form set forth in Exhibit A (the “Transition Services Statement of Work”). The Transition
Services Statement of Work shall be executed by both parties on the Effective Date. The Transition Services Statement of Work shall include a description of the scope of work, responsibilities, deliverables, timelines, budget and payment schedule
and shall be subject to all of the provisions of this Agreement, in addition to the specific details set forth therein. To the extent any provisions of the Transition Services Statement of Work conflict or are inconsistent with the provisions of
this Agreement, the provisions of this Agreement shall control. When executed by both parties, the Transition Services Statement of Work shall constitute a separate and distinct contract between the parties and shall be incorporated herein by
reference and form a part hereof. Unless otherwise expressly stated in the Transition Services Statement of Work, the provisions of the Transition Services Statement of Work shall be independent of the provisions of any Prior Statement of Work (as
defined below).

C. All Statements of Work (as defined in the Prior Agreement) entered into under the Prior Agreement and in effect as of the time hereof (the “Prior Statements of Work”) are hereby terminated and of no further force and effect. 

	
2.RESPONSIBILITIES

Provider shall use commercially reasonable efforts to perform the services and fulfill the obligations and responsibilities set forth in this Agreement and the Transition Services Statement of Work (such services, obligations and
responsibilities are referred to herein collectively as the “Services”). Provider shall use commercially reasonable efforts to provide all personnel, equipment and resources
necessary to perform the Services.

	
3.SUBCONTRACTING

Provider may engage any contractor, subcontractor or other vendor (collectively, “Subcontractor”) to perform any obligations under this Agreement. Provider shall
be responsible for the management of all Subcontractors. The engagement by Provider of any Subcontractor shall not relieve Provider of its obligations under this Agreement or the Transition Services Statement of Work. Any agreement between Provider
and the Subcontractor pertaining to the Services shall be consistent with the provisions of this Agreement. 

	
4.CHANGES IN SCOPE

The Transition Services Statement of Work may be amended by a written amendment which is executed by both parties (a “Change Order”). Each Change Order shall set
forth the agreed changes to the applicable task, responsibility, budget, timeline or other matter. A Change Order shall become effective only upon the execution of the Change Order by both parties. As used in this Agreement, the term “Transition Services Statement of Work” shall mean the Transition Services Statement of Work as amended by any Change Orders thereto. Each Change Order shall reference this Agreement and the
Transition Services Statement of Work and shall be subject to the provisions of this Agreement. To the extent any provisions of a Change Order conflict or are inconsistent with the provisions of this Agreement, the provisions of this Agreement shall
control. All Change Orders shall be incorporated herein by reference and form a part hereof.

	
5.TERM

The term of this Agreement shall begin as of the Effective Date and shall terminate automatically on the date that is the later of (a) the date on which all the Services and responsibilities described in the Transition Services
Statement of Work have been completed and discharged and the deliverables provided in the Transition Services Statement of Work have been provided or (b) September 30, 2009; provided, however, that this Agreement and the Transition Services
Statement of Work may be earlier terminated in accordance with the provisions of this Agreement. 

	
6.PAYMENTS AND SCHEDULES

A. Payment shall be due to Provider at such times and in such amounts as set forth in this Agreement and the Transition Services Statement of Work applicable to the Services being provided. All costs and rates set forth in the
Transition Services Statement of Work shall remain firm for the duration of the Services performed under the Transition Services Statement of Work. Provider shall submit to Purchaser Provider’s invoice in accordance with the schedule set forth
in the Transition Services Statement of Work, and Purchaser shall pay to Provider the applicable amount within thirty (30) days following receipt by Purchaser of such invoice. Payment shall be made by wire transfer to Provider or by such other means
as is agreed by the parties.

B. Purchaser will be in default with respect to payment, without receipt of a reminder from Provider, for all payments not paid timely. In case of default with respect to payment, any 

- 2 -

amount not paid timely shall bear interest from its due date through the date of effective receipt of payment at the rate equal to the lesser of the maximum rate allowable under applicable law or one percent (1%) over the prime
rate published in the eastern edition of The Wall Street Journal on the date such payment was due or a comparable newspaper if The Wall Street
Journal shall cease publishing the prime rate. All monies due to Provider hereunder are payable in United States dollars. 

C. All prices under this Agreement are net prices. Any payment under this Agreement shall be made plus value added tax, if value added tax is levied under applicable law, and shall be grossed up for any withholding tax that may be
required under applicable law. Fees of any nature levied or incurred on account of any payments from Purchaser to Provider accruing under this Agreement, by national, state or local governments, will be assumed and paid by Purchaser.

	
7.NOTICES

All notices, invoices and other communications under this Agreement shall be in writing and shall be deemed to have been duly given when (i) delivered by hand (with written confirmation of receipt), or (ii) when received by the
addressee, if sent by an internationally recognized overnight delivery service (receipt requested), to the appropriate address set forth below (or to such other address as a party may designate by notice to the other party):

	
If to Purchaser:

ExCRX Singapore Pte. Ltd.

c/o Forma Therapeutics, Inc.

790 Memorial Drive

Cambridge, MA 02139

Attention: Director of Corporate Development

If to Provider:

CombinatoRx, Incorporated

245 1st Street 

Cambridge, MA 02142

Attention: General Counsel 

8.INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT

On the Effective Date, the parties shall enter into the Intellectual Property Assignment Agreement in the form attached hereto as Exhibit B. The Intellectual Property
Assignment Agreement shall set forth the parties’ respective rights with respect to intellectual property created pursuant to this Agreement and the Prior Agreement.

	
9.CONFIDENTIAL INFORMATION

A. Neither Provider nor Purchaser shall disclose to any person or entity, or use for any purpose other than pursuant to this Agreement, any and all trade secrets, privileged records or other confidential or proprietary data or
information disclosed by or on behalf of the other party 

- 3 -

pursuant to this Agreement or any previous confidentiality agreement(s) (collectively “Confidential Information”); except that either party shall have the right
to disclose Confidential Information of the other party to employees of the first party’s Affiliates who are bound by like obligations of non-disclosure and non-use. Such obligation of each party of non-disclosure and non-use with respect to
Confidential Information disclosed by or on behalf of the other party shall not apply to the following: (1) Information at or after such time that it is or becomes publicly available through no fault of the receiving party or its Affiliates; (2)
Information that is already known to the receiving party or its Affiliates as shown by prior written records and was not obtained directly or indirectly from the disclosing party; (3) Information at or after such time that it is disclosed to the
receiving party or its Affiliates by another party with the legal right to do so; (4) Information that is required to be released by law, judicial process, court order or administrative request, provided that the receiving party limits disclosure to
that purpose, after giving the disclosing party notice in time to allow the disclosing party to object to or seek to limit such disclosure and the receiving party cooperates with the disclosing party as the disclosing party may reasonably request;
(5) Information that is developed by or for the receiving party or its Affiliates independently of access to the disclosing party’s Confidential Information; or (6) Information that is disclosed with the disclosing party’s express prior
written consent and pursuant to the terms of such consent.

B. The obligations of each party under this Section 9 shall survive and continue for seven (7) years after the Effective Date. 

	
10.PUBLICITY; DISCLOSURE

Except as required by law, Provider and Purchaser each agrees not to issue any press release or like public announcement, whether oral or written, relating to this Agreement or the terms hereof without the prior written consent of
the other party.

	
11.PURCHASER REPORTING

During the term of this Agreement and until July 31, 2009, Purchaser shall provide to Provider such information and reports regarding the Services and the Purchaser’s business as Provider may reasonably require for the
purposes of fulfilling Provider’s legal and regulatory obligations, including, without limitation, the reporting and disclosure requirements of the United States Securities and Exchange Commission and the NASDAQ.

	
12.INDEMNIFICATION

A. Purchaser shall indemnify and hold harmless Provider and its Affiliates and their respective directors, officers and employees from and against any and all claims, proceedings, damages or liabilities arising out of
Purchaser’s breach of any of the provisions of this Agreement or Purchaser’s negligence or willful misconduct in the performance of this Agreement; provided that, in regard to any such claim or proceeding that is made by a third party,
Purchaser, in 

- 4 -

reasonable consultation with Provider, shall have the right to select defense counsel and control the defense of such third party claim or proceeding.

B. Provider shall indemnify and hold harmless Purchaser and its Affiliates and their respective directors, officers and employees from and against any and all claims, proceedings, damages or liabilities arising out of
Provider’s breach of any of the provisions of this Agreement or Provider’s negligence or willful misconduct in the performance of this Agreement; provided that, in regard to any such claim or proceeding that is made by a third party,
Provider, in reasonable consultation with Purchaser, shall have the right to select defense counsel and control the defense of such third party claim or proceeding. 

C. Any party seeking indemnification hereunder shall notify the other party in writing promptly after receipt of any third party claim or proceeding in respect of which it intends to base a claim for indemnification hereunder, but
the failure or delay so to notify the indemnifying party shall not relieve the indemnifying party of any obligation or liability that it may have to the indemnified party except to the extent that its ability to defend or resolve the claim or
proceeding is adversely affected thereby. The indemnifying party shall provide diligent defense against any third party claim or proceeding with respect to the subject of the indemnity contained herein. The indemnifying party shall not settle any
such claim or proceeding without the prior written consent of the indemnified party, which consent shall not be unreasonably withheld. The indemnified party shall cooperate with and provide assistance to the indemnifying party and its legal
representatives as may be reasonably requested by the indemnifying party in connection with such claim or proceeding. The indemnified party shall have the right to select and to obtain representation by separate legal counsel at its own
expense.

	
13.INSURANCE

A. Purchaser shall maintain insurance coverage at levels sufficient to support the indemnification obligations assumed herein, in amounts and on other terms reasonably acceptable to Provider. Purchaser shall provide Provider with
evidence of such insurance upon Provider’s request.

B. Provider shall maintain insurance coverage at levels sufficient to support the indemnification obligations assumed herein, in amounts and on other terms reasonably acceptable to Purchaser. Provider shall provide Purchaser with
evidence of such insurance upon Purchaser’s request.

	
14.TERMINATION

A. (i) Any party may terminate this Agreement immediately by written notice to other party, in the event of a material breach of this Agreement or the Transition Services Statement of Work by the other party, if the non-breaching
party shall have given written notice to the breaching party specifying the nature of the breach and such breach shall not have been substantially cured within 30 days (5 days in the case of any payment breach) after such notice of breach. Any
termination by any party for breach by the other party shall be without prejudice to any damages or remedies to which it may be entitled from the other party; and (ii) any party may terminate this Agreement immediately by written notice to the other
party, if the other party becomes insolvent, makes or has made an assignment for the benefit of creditors, is the subject of 

- 5 -

proceedings in voluntary or involuntary bankruptcy instituted on behalf of or against it (except for involuntary bankruptcies which are dismissed within ninety (90) days) or has a receiver or trustee appointed for substantially
all of its property. The Transition Services Statement of Work shall terminate immediately upon the termination of this Agreement.

B. The expiration or termination of this Agreement or the Transition Services Statement of Work shall not affect the rights and obligations of the parties accrued prior to such expiration or termination. The rights and obligations
under Sections 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 19 and 22 of this Agreement shall survive the expiration or termination of this Agreement. 

15.CONFORMANCE WITH LAW; REPRESENTATION

Provider shall use commercially reasonable efforts to perform the Services and discharge obligations under this Agreement and the Transition Services Statement of Work in conformance with (i) professional standards and practices,
(ii) this Agreement and the Transition Services Statement of Work, and (iii) all applicable laws and regulations. Without limiting the generality of the foregoing, Provider shall retain all records relating to the Services and Provider’s
performance of this Agreement and the Transition Services Statement of Work for the time periods required by applicable federal regulations.

	
16.APPLICABLE LAW

This Agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts, without regard to the conflicts of laws principles thereof.

	
17.INDEPENDENT CONTRACTOR

A. Provider acknowledges and agrees that it is solely responsible for the compensation of the personnel assigned to the Services, and as employer, shall be responsible for withholding all federal, state, local or other applicable
taxes and similar items. Provider also shall be responsible for all other employer related obligations, including providing appropriate insurance coverage and employee benefits, and making all other deductions required by law affecting the gross
wages of each employee.

B. Provider personnel assigned to the Services are not nor shall they be deemed to be at any time during the term of this Agreement employees of Purchaser. The parties’ relationship and status with each other shall be that of
independent contractors, and neither party shall state or imply, directly or indirectly, that it is empowered or authorized to commit or bind the other party or to incur any liabilities or expenses on behalf of the other party or to enter into any
oral or written agreement in the name or on behalf of the other party. Nothing herein shall create, expressly or by implication, a partnership, joint venture, agency, or other association of the parties.

	
18.ENTIRE AGREEMENT

This Agreement, the Transition Services Statement of Work and any Change Orders entered into pursuant hereto represent the entire agreement and understanding of the parties with respect to 

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the subject matter hereof and supersede all prior communications and agreements between the parties with respect to such subject matter. This Agreement shall supersede all prior confidentiality agreements between Purchaser and
Provider with respect to Confidential Information disclosed pursuant to this Agreement. The Transition Services Statement of Work and Change Orders shall be incorporated in this Agreement by reference and form a part hereof. In the event of any
inconsistency between this Agreement and the Transition Services Statement of Work or any Change Order, the provisions of this Agreement shall govern. This Agreement shall not be modified or amended except by a written agreement signed by the
parties hereto.

	
19.ASSIGNMENT

Except as expressly provided in this Section, this Agreement and the Transition Services Statement of Work, and all rights and obligations hereunder and thereunder, may not be assigned by either party without the express written
consent of the other party. Any assignment or attempt at the same in contravention of the foregoing shall be void and of no effect. Either party may assign this Agreement and the Transition Services Statement of Work, and all rights and obligations
hereunder and thereunder, in whole or in part without the consent of the other party, to any of the assignment party’s affiliates or in connection with the transfer or sale of all or substantially all of the assigning party’s assets or
business or its merger or consolidation with another company. This Agreement shall be binding upon and inure to the benefit of the parties and their respective successors and permitted assigns.

	
20.WAIVER

No waiver of any term, provision or condition of this Agreement whether by conduct or otherwise in any one or more instances shall be deemed to be or construed as a further or continuing waiver of any such term, provision or
condition, or as waiver of any other term, provision or condition of this Agreement.

	
21.FORCE MAJEURE

Neither party shall be liable to the other for failure or delay in performing its obligations under this Agreement, to the extent such failure or delay is caused by circumstances beyond such party's control, such as labor
disturbances or labor disputes, accidents, civil disorders or commotions, acts of aggression or acts of God. In such event, the party affected shall use reasonable efforts to resume performance of this Agreement.

	
22.MISCELLANEOUS

A. As used in this Agreement, an “Affiliate” of any party shall mean any corporation, company, partnership, firm or other entity that, directly or indirectly,
controls, is controlled by or is under common control with such party. For purposes of this definition “control” of any party or entity shall mean the beneficial ownership of fifty
percent (50%) or more of the voting or income interest in such party or entity.

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B. Should one or more provisions of this Agreement or the Transition Services Statement of Work become void or unenforceable as a matter of law, then this Agreement or the Transition Services Statement of Work shall be construed
as if such provision were not contained herein or therein and the remainder of this Agreement or the Transition Services Statement of Work shall be in full force and effect, and the parties will endeavor in good faith to substitute for the invalid
or unenforceable provision a valid and enforceable provision which conforms as nearly as possible with the original intent of the parties.

C. The captions and headings used in this Agreement, the Transition Services Statement of Work and any Change Order are for convenience of reference only and shall not affect the meaning or interpretation hereof or thereof in any
way.

D. This Agreement, the Transition Services Statement of Work and any Change Order may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same
instrument.

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IN WITNESS WHEREOF, the parties hereto have executed this Transition Services Agreement in duplicate.

EXCRX SINGAPORE PTE. LTD. COMBINATORX, INCORPORATED (f.k.a. COMBINATORX (SINGAPORE) PTE. LTD.)

	
By /s/ Yeo Su Ling

Name: Yeo Su Ling

Title: Director

Date: June 2, 2009

	
By /s/ Robert Forrester

Name: Robert Forrester

Title: EVP & CFO

Date: June 2, 2009

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EXHIBIT A

TRANSITION SERVICES STATEMENT OF WORK

A-1

EXHIBIT B

INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT

A-2

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