Document:

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                                                                     EXHIBIT 4.7

These securities have not been registered under the Securities Act of 1933 or
any state securities laws. These securities have been acquired for investment
and not with a view to distribution or resale, and may not be sold, mortgaged,
pledged, hypothecated or otherwise transferred without registration under the
Securities Act of 1933 and qualification under state securities laws, or an
opinion of counsel acceptable to the corporation that registration and
qualification is not required.

                         TITAN MOTORCYCLE CO. OF AMERICA

                          Common Stock Purchase Warrant

To Subscribe for and Purchase                                    March 7, 2000
1,190 Shares of Common Stock of
TITAN MOTORCYCLE CO. OF AMERICA

     THIS CERTIFIES that, for good and valuable consideration, the sufficiency
of which is hereby acknowledged, Mr. Richard Cohn or his registered assigns (the
"Holder") is entitled to subscribe for and purchase from TITAN MOTORCYCLE CO. OF
AMERICA, a Nevada corporation (hereinafter called the "Company"), up to 1,190
shares (subject to adjustment as hereinafter provided) of fully paid and
non-assessable Common Stock of the Company (the "Common Stock"), subject to the
provisions and upon the terms and conditions hereinafter set forth at the price
of $2.00 per share (such price as may from time to time be adjusted as provided
herein is called the "Warrant Price"), at or prior to 5:00 p.m. Pacific time on
March 7, 2005 (the "Exercise Period").

     This Warrant and any Warrant subsequently issued upon exchange or transfer
hereof are hereinafter collectively called the "Warrant."

     Section 1. EXERCISE OF WARRANT. The rights represented by this Warrant may
be exercised by the Holder, in whole or in part (but not as to fractional
shares) at any time or from time to time during the Exercise Period by the
completion of the purchase form attached hereto and by the surrender of this
Warrant (properly endorsed) at the office of the Company as it may designate by
notice in writing to the Holder hereof at the address of the Holder appearing on
the books of the Company, and by payment to the Company of the Warrant Price in
cash or by certified or official bank check, for each share being purchased. In
the event of any exercise of the rights represented by this Warrant, a
certificate or certificates for the shares of Common Stock so purchased,
registered in the name of the Holder or its nominee or other party designated in
the purchase form by the Holder hereof, shall be delivered to the Holder as soon
as practicable after the exercise of this Warrant, and in any event within five
(5) business days after the date on which the rights represented by this Warrant
shall have been so exercised; and, unless this Warrant has expired or has been
exercised in full, a new Warrant representing the number of shares (except a
remaining fractional share), if any, with respect to which this Warrant shall
not then have been exercised shall also be issued to the Holder within such
time. The person in whose name any certificate for shares of Common Stock is
issued upon exercise of this Warrant shall for all purposes be deemed to have
become the holder of record of such shares on the date on which this Warrant was
surrendered and payment of the Warrant is made, except that, if the
<PAGE>   2
date of such surrender and payment is a date on which the stock transfer books
of the Company are closed, such person shall be deemed to have become the holder
of such shares at the close of business on the next succeeding date on which the
stock transfer books are open. No fractional shares shall be issued upon
exercise of this Warrant and no payment or adjustment shall be made upon any
exercise on account of any cash dividends on the Common Stock issued upon such
exercise. If any fractional interest in a share of Common Stock would, except
for the provision of this Section 1, be delivered upon such exercise, the
Company, in lieu of delivery of a fractional share thereof, shall pay to the
Holder an amount in cash equal to the current market price of such fractional
share as determined in good faith by the Board of Directors of the Company.
Current market price means the closing price of the Common Stock on the relevant
date as reported on the Nasdaq SmallCap Market (or any national securities
exchange, national market including the Nasdaq National Market, or other
quotation system on which the Common Stock is then listed) or, if no prices are
reported for that date, such prices on the next preceding date for which closing
prices were reported, or if the Common Stock is not publicly traded, by such
methods or procedures as may be established from time to time by the Board of
Directors of the Company in good faith.

     Section 2. STOCK SPLITS, CONSOLIDATION, MERGER, AND SALE. In the event that
before the issuance of the shares of Common Stock into which this Warrant may be
exercised the outstanding shares of Common Stock shall be split, combined, or
consolidated, by dividend, reclassification or otherwise, into a greater or
lesser number of shares of Common Stock or any other class or classes of stock,
as appropriate, the Warrant Price in effect immediately prior to such
combination or consolidation and the number of shares purchasable under this
Warrant shall, concurrently with the effectiveness of such combination or
consolidation, be proportionately adjusted. If there shall be effected any
consolidation or merger of the Company with another corporation, or a sale of
all or substantially all of the Company's assets to another corporation, and if
the holders of Common Stock shall be entitled pursuant to the terms of any such
transaction to receive stock, securities or assets with respect to or in
exchange for Common Stock, then, as a condition of such consolidation, merger or
sale, lawful and adequate provisions shall be made whereby the Holder of this
Warrant shall thereafter have the right to receive, upon the basis and upon the
terms and conditions specified herein and in lieu of the shares of Common Stock
immediately theretofore receivable upon the exercise of such Warrant, such
shares of stock, securities or assets as may be issuable or payable with respect
to or in exchange for a number of outstanding shares of such Common Stock equal
to the number of shares of such Common Stock immediately theretofore so
receivable had such consolidation, merger or sale not taken place, and in any
such case appropriate provisions shall be made with respect to the rights and
interests of the Holder to the end that the provisions hereof shall thereafter
be applicable, as nearly as may be, in relation to any shares of stock,
securities or assets thereafter deliverable upon the exercise of this Warrant.

         (a) STOCK TO BE RESERVED. The Company will at all times reserve and
keep available out of its authorized Common Stock, solely for the purpose of
issue upon the exercise of this Warrant as herein provided, such number of
shares of Common Stock as shall then be issuable upon the exercise of this
Warrant.
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         (b) ISSUE TAX. The issuance of certificates for shares of Common Stock
upon exercise of this Warrant shall be made without charge to the Holders of
this Warrant for any issuance tax in respect thereof provided that the Company
shall not be required to pay any tax which may be payable in respect of any
transfer involved in the issuance and delivery of any certificate in a name
other than that of the Holder of this Warrant, which shall be borne by the
Holder.

         (c) CLOSING OF BOOKS. The Company will not close its transfer books to
impair any issuance of the shares of Common Stock upon the exercise of this
Warrant.

     Section 3. NOTICES OF RECORD DATES.  In the event of:

         (a) any taking by the Company of a record of the holders of any class
of securities for the purpose of determining the holders thereof who are
entitled to receive any dividend or other distribution (other than cash
dividends out of earned surplus), or any right to subscribe for, purchase or
otherwise acquire any shares of stock of any class or any other securities or
property, or to receive any other right, or

         (b) any capital reorganization of the Company, any reclassification or
recapitalization of the capital stock of the Company or any transfer of all or
substantially all the assets of the Company to or consolidation or merger of the
Company with or into any other corporation, or

         (c) any voluntary or involuntary dissolution, liquidation or winding-up
of the Company, then and in each such event the Company will give notice to the
Holder of this Warrant specifying (i) the date on which any such record is to be
taken for the purpose of such dividend, distribution or right and stating the
amount and character of such dividend, distribution or right, and (ii) the date
on which any such reorganization, reclassification, recapitalization, transfer,
consolidation, merger, dissolution, liquidation or winding-up is to take place,
and the time, if any is to be fixed, as of which the holders of record of Common
Stock will be entitled to exchange their shares of Common Stock for securities
or other property deliverable upon such reorganization, reclassification,
recapitalization, transfer, consolidation, merger, dissolution, liquidation or
winding-up. Such notice shall be given at least ten (10) days and not more than
ninety (90) days prior to the date therein specified, and such notice shall
state that the action in question or the record date is subject to the
effectiveness of a registration statement under the Securities Act of 1933, as
amended (the "Securities Act") or to a favorable vote of shareholders, if either
is required. Any failure to provide a notice hereunder shall not affect the
corporate action taken.

     Section 4. NO SHAREHOLDER RIGHTS OR LIABILITIES. This Warrant shall not
entitle the Holder hereof to any voting rights or other rights as a shareholder
of the Company. No provision hereof, in the absence of affirmative action by the
Holder hereof to purchase shares of Common Stock, and no mere enumeration hereon
of the rights or privileges of the Holder hereof, shall give rise to any
liability of such Holder for the Warrant Price or as a shareholder of the
Company, whether such liability is asserted by the Company or by creditors of
the Company.

     Section 5. REPRESENTATIONS OF HOLDER. The Holder hereby represents and
acknowledges to the Company as of the date hereof and as of each exercise of
this Warrant that:
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         (a) this Warrant, the Common Stock issuable upon exercise of this
Warrant and any securities issued with respect to any of them by way of a stock
dividend or stock split or in connection with a recapitalization, merger,
consolidation or other reorganization will be "restricted securities" as such
term is used in the rules and regulations under the Securities Act; such
securities have not been and may not be registered under the Securities Act or
any state securities law; and such securities must be held indefinitely unless
registration is effected or transfer can be made pursuant to appropriate
exemptions;

         (b) the Holder has read, and fully understands, the terms of this
Warrant set forth on its face and the attachments hereto, including the
restrictions on transfer contained herein;

         (c) the Holder is purchasing for investment for its own account and not
with a view to or for sale in connection with any distribution of this Warrant
or the Common Stock of the Company issuable upon exercise of this Warrant and it
has no intention of selling such securities in a public distribution in
violation of the federal securities laws or any applicable state securities
laws;

         (d) the Holder is an "accredited investor" within the meaning of
paragraph (a) of Rule 501 of Regulation D promulgated by the Securities and
Exchange Commission and an "excluded purchaser" within the meaning of Section
25102(f) of the California Corporate Securities Law of 1968; and

         (e) the Company may affix the following legend (in addition to any
other legend(s), if any, required by applicable state corporate and/or
securities laws) to certificates for shares of Common Stock (or other
securities) issued upon exercise of this Warrant:

         These securities have not been registered under the Securities Act of
         1933 or any state securities laws. These securities have been acquired
         for investment and not with a view to distribution or resale, and may
         not be sold, mortgaged, pledged, hypothecated or otherwise transferred
         without registration under the Securities Act of 1933 and qualification
         under state securities laws, or an opinion of counsel acceptable to the
         corporation that registration and qualification is not required.

     Section 6.  RESTRICTIONS ON TRANSFER; REGISTRATION RIGHTS.

         (a) The Holder may not transfer this Warrant without the written
consent of the Company and an opinion of counsel acceptable to the Company that
the transfer may be effected in compliance with exemptions under the Securities
Act and applicable state securities laws. The Holder may not transfer the Common
Stock underlying the Warrant unless there is an effective registration statement
in effect under the Securities Act and the transfer is qualified under
applicable state securities laws, or the Holder has delivered to the Company an
opinion of counsel acceptable to the Company that registration and qualification
is not required.

         (b) The Company is obligated to cause a registration statement to be
filed under the Securities Act on or before April 7, 2000 pursuant to a
Registration Rights Agreement between the Company and Advantage Fund II Ltd. and
a Registration Rights Agreement between the Company and Koch Investment Group
Limited (the "Registration Statement"). The Company
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shall include in such Registration Statement all of the Common Stock issuable
upon conversion of the Warrant.

         (c) All fees, disbursements, and out-of-pocket expenses incurred in
connection with the filing of the Registration Statement under Paragraph (a) of
Section 6 and in complying with applicable securities and Blue Sky laws shall be
borne by the Company, provided, however, that any expenses of the individual
Holder or holders of the underlying securities, including but not limited to the
Holder or holders' attorneys' fees and discounts and commissions, shall be borne
by the Holder and holders of the Common Stock. The Company at its expense will
supply the Holder and any holder of Common Stock with copies of the Registration
Statement and the prospectus or offering circular included therein and other
related documents in such quantities as may be reasonably requested by the
Holder or holder of Common Stock.

         (d) The Company shall have no obligation to register the Warrant but
shall be obligated to register the Common Stock issuable upon exercise of the
Warrant in accordance with Paragraph (b) of Section 6.

         (e) The Company agrees that it will use its best efforts to keep such
Registration Statement effective until March 7, 2005 or such earlier date as all
Common Stock covered by such Registration Statement have been disposed of
pursuant thereto.

         (f) The Holder agrees to cooperate with the Company and to provide the
Company on its request with all information concerning the Holder, the Warrant
issued hereunder, any Common Stock acquired upon exercise of the Warrant and the
means or methods of intended disposition of the Common Stock pursuant to the
Registration Statement that may reasonably be requested by the Company in order
for the Company to perform its obligation under this Section 6.

     Section 7. LOST, STOLEN, MUTILATED, OR DESTROYED WARRANT. If this Warrant
is lost, stolen, mutilated, or destroyed, the Company may, on such terms as to
indemnity or otherwise as it may in its discretion reasonably impose (which
shall, in the case of a mutilated Warrant, include the surrender thereof), issue
a new Warrant of like denomination and tenor as the Warrant so lost, stolen,
mutilated, or destroyed.

     Section 8. PRESENTMENT. Prior to due presentment of this Warrant, together
with a completed assignment form attached hereto for registration of transfer,
the Company may deem and treat the Holder as the absolute owner of the Warrant,
notwithstanding any notation of ownership or other writing thereon, for the
purpose of any exercise thereof and for all other purposes, and the Company
shall not be affected by any notice to the contrary.

     Section 9. NOTICE. Notice or demand pursuant to this Warrant shall be
sufficiently given or made, if sent by first-class mail, postage prepaid,
addressed, if to the Holder of this Warrant, to the Holder at its last known
address as it shall appear in the records of the Company, and if to the Company,
at 2222 West Peoria Avenue, Phoenix, Arizona 85029, Attention: Chief Financial
Officer. The Company may alter the address to which communications are to be
sent by giving notice of such change of address in conformity with the
provisions of this Section 9 for the giving of notice.
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      Section 10. GOVERNING LAW. The validity, interpretation, and performance
of this Warrant shall be governed by the laws of the State of Arizona without
regard to principles of conflicts of laws.

      Section 11. SUCCESSORS, ASSIGNS. Subject to the restrictions on transfer
by Holder set forth in Section 6 hereof, all the terms and provisions of the
Warrant shall be binding upon and inure to the benefit of and be enforceable by
the respective successors and assigns of the parties hereto.

      Section 12. AMENDMENT. This Warrant may be modified, amended, or
terminated by a writing signed by the Company and the Holder.

      Section 13. SEVERABILITY. Should any part but not the whole of this
Warrant for any reason be declared invalid, such decision shall not affect the
validity of any remaining portion, which remaining portion shall remain in force
and effect as if this Warrant had been executed with the invalid portion thereof
eliminated, and it is hereby declared the intention of the parties hereto that
they would have executed the remaining portion of this Warrant without including
therein any such part which may, for any reason, be hereafter declared invalid.

      Section 14. NO IMPAIRMENT. The Company will not, by any voluntary action,
avoid or seek to avoid the observance or performance of any of the terms to be
observed or performed hereunder by the Company, but will at all times in good
faith assist in the carrying out of all the provisions of this Warrant and in
the taking of all such action as may be necessary or appropriate in order to
protect the rights of the Holder of this Warrant against impairment.

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     IN WITNESS WHEREOF, the Company has caused this Warrant to be duly executed
and delivered on and as of the day and year first above written by one of its
officers thereunto duly authorized.

                                           TITAN MOTORCYCLE CO. OF AMERICA,
                                           a Nevada corporation

Dated: ____________  ______

                                           By: ________________________________

                                           Title: _____________________________

     The undersigned Holder agrees and accepts this Warrant and acknowledges
that it has read and confirms each of the representations contained in Section
5.

                                            RICHARD COHN

                                            ___________________________________
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                                  PURCHASE FORM

(To be executed by the Warrant Holder if he desires to exercise the Warrant in
whole or in part)

To:  TITAN MOTORCYCLE CO. OF AMERICA

     The undersigned, whose Social Security or other identifying number is
_______________, hereby irrevocably exercises the attached Warrant, agrees to
purchase ______________ shares of Common Stock, and tenders payment herewith to
the order of TITAN MOTORCYCLE CO. OF AMERICA in the amount of
$_____________________________.

The undersigned requests that certificates for such shares be issued as follows:

Name: __________________________________

Address: ________________________________

         ________________________________

         ________________________________

Deliver to: _______________________________

Address: ________________________________

         ________________________________

         ________________________________

and, if the number of shares shall not be all the shares purchasable under the
Warrant, that a new Warrant for the balance remaining of the shares purchasable
under the attached Warrant be registered in the name of, and delivered to, the
undersigned at the address stated below:

Address: ________________________________

         ________________________________

         ________________________________

By this exercise,

         The undersigned hereby reaffirms its representations and warrants set
forth forth in Section 5 of the Warrant as of the date hereof.

Dated:______________, _____         Signature: _________________________________

                                       (Signature must conform in all respects
                                       to the name of the Warrant Holder as
                                       specified on the face of the Warrant,
                                       without alteration, enlargement or any
                                       change whatsoever)
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                                   ASSIGNMENT

(To be executed by the Warrant Holder if he desires to effect a transfer of the
Warrant)

     FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers
unto ____________ ______________________________, whose Social Security or other
identification number is _________________ [residing/located] at
____________________________ ____________________ the attached Warrant, and
appoints _____________________________ residing at
_______________________________________
_____________________________________________ the undersigned's attorney-in-fact
to transfer said Warrant on the books of the Company, with full power of
substitution in the premises.

Dated:_______________, _____

In the presence of:

_________________________________      ________________________________________

                                       (Signature must conform in all respects
                                       to the name of the Warrant Holder as
                                       specified on the face of the Warrant,
                                       without alteration, enlargement or any
                                       change whatsoever).<PAGE>

Exhibit 4.1

                       PHARMAKINETICS LABORATORIES, INC.
                            ARTICLES SUPPLEMENTARY

     PharmaKinetics Laboratories, Inc., a Maryland corporation having its
principal office in Baltimore, Maryland (the "Corporation"), hereby certifies to
the State Department of Assessments and Taxation of Maryland that:

     FIRST: Pursuant to authority expressly vested in the Board of Directors of
the Corporation by Article Sixth of the Charter of the Corporation, the Board of
Directors has duly classified 250,000 shares of the Preferred Stock of the
Corporation as a class designated "Class B Convertible Preferred Stock."

     SECOND: A description of such Class B Convertible Preferred Stock,
including the preferences, conversion and other rights, voting powers,
restrictions, dividends, and qualifications, all as set by the Board of
Directors of the Corporation, is as follows:

1.   DESIGNATION AND AMOUNT

     A total of 250,000 shares of the Corporation's Preferred Stock shall be
designated the "Class B Convertible Preferred Stock."

2.   VOTING RIGHTS

     General. Each holder of Class B Convertible Preferred Stock shall be
     -------
entitled to vote on all matters submitted to a vote of the holders of the Common
Stock of the Corporation and, with respect to each such matter, shall be
entitled to that number of votes equal to the number of whole shares of Common
Stock into which such holder's shares of Class B Convertible Preferred Stock
could be converted, pursuant to the provisions of Section 5, on the record date
for the determination of stockholders entitled to vote on such matters, or if no
such record date is established, on the date such vote is taken. Except as
otherwise provided in the Corporation's charter regarding matters as to which
the holders of the Corporation's Class A Convertible Preferred Stock shall vote
separately as a class (with respect to which matters the holders of shares of
Class B Convertible Preferred Stock shall not be entitled to vote), or otherwise
required by law, the holders of shares of Class B Convertible Preferred Stock
and the holders of shares of Class A Convertible Preferred Stock and the holders
of shares of Common Stock shall vote together as a single class on matters
submitted to the stockholders of the Corporation.

3.   DIVIDENDS

     If the Corporation declares a dividend on its Common Stock, each holder of
shares of Class B Convertible Preferred Stock shall be entitled to participate
in such dividend as if such holder was the holder of the number of whole shares
of Common Stock into which such holder's shares of Class B Convertible Preferred
Stock could be converted, pursuant to the provisions of Section 5, on the record
date for the determination of holders of Common Stock entitled to receive the
declared dividend.

4.   LIQUIDATION, DISSOLUTION, OR WINDING-UP

                                       1
<PAGE>

     Upon the liquidation, dissolution, or winding-up of the Corporation,
whether voluntary or involuntary, the holders of Class B Convertible Preferred
Stock shall be entitled to be paid out of the assets of the Corporation
available for distribution to its stockholders, whether from capital, surplus or
earnings, after payment of distributions in respect of the preferential rights
of any other Preferred Stock then outstanding (the "Proceeds") and each holder
of Class B Convertible Preferred Stock shall share in the Proceeds pro rata with
the holders of Common Stock and the holders of any Preferred Stock having
rights, privileges or preferences on parity with or subordinate to the Class B
Convertible Preferred Stock.

5.   CONVERSION.

     5.1  Conversion Right and Conversion Rate.  Any holder of Class B
          ------------------------------------
Convertible Preferred Stock shall have the right, at the holder's option, to
convert at any time, or from time to time, any or all of the such holder's
shares of Class B Convertible Preferred Stock into fully-paid and nonassessable
shares of the Common Stock of the Corporation, subject to the terms and
conditions of this Section 5. The number of shares of Common Stock issuable for
each share of Class B Convertible Preferred Stock upon any such conversion
(herein called the "Conversion Rate") shall be one (1) share of Common Stock for
each share of Class B Convertible Preferred Stock; provided, however, that if
the application of the then current Conversion Rate to the aggregate number of
shares of Class B Convertible Preferred Stock surrendered by a single holder in
a single transaction would result in a fraction, then the next lower whole
number of shares of Common Stock shall be issuable upon such conversion. The
Conversion Rate shall be subject to adjustment from time to time in certain
instances as provided in Section 5.3. The Corporation shall make no payment or
adjustment on account of any dividends accrued on the Common Stock issuable upon
such conversion, or on account of the rounding down to the next lower whole
number of shares issuable upon any conversion.

     5.2  Manner of Conversion.    In order to convert shares of Class B
          --------------------
Convertible Preferred Stock into Common Stock, the record holder of such shares
shall surrender the certificate or certificates therefor, duly endorsed or
accompanied by duly executed stock powers, at the principal office of the
Corporation. Together with such certificates, the converting holder shall give a
written conversion notice to the Corporation of the election to convert a
specified number of shares of Class B Convertible Preferred Stock. The
converting holder shall state in its notice of conversion the name or names that
shall appear on the certificate or certificates for Common Stock issuable upon
such conversion. The Corporation shall, as soon as practicable thereafter, cause
to be issued and delivered to the converting holder, or to the converting
holder's designated transferees or nominees, if permitted by applicable law,
certificates for the number of full shares of Common Stock to which the
converting holder is entitled. If the converting holder has elected to convert
only a portion of the shares of Class B Convertible Preferred Stock represented
by the surrendered certificates, the Corporation shall issue, at its expense, a
new certificate representing the unconverted shares of Class B Convertible
Preferred Stock, registered in the name of the converting holder, or in the name
or names of the converting holder's designated transferees or nominees, if
permitted by applicable law. Shares of Class B Convertible Preferred Stock shall
be deemed to have been converted as of the close of business on the date when
the surrender of the certificates therefor and the giving of notice as required
above has been completed. The person or persons entitled to receive the Common
Stock issuable upon conversion shall be treated for all purposes as the record
holder or holders of such Common Stock at and after such time.

                                       2

<PAGE>

     5.3. Adjustment to Conversion Rate.
          -----------------------------

     (a)  Generally. In order to prevent dilution of the conversion rights
          ---------
granted under Section 5.1 hereof, the Conversion Rate in effect at any time
shall be subject to adjustment from time to time pursuant to this Section 5.3.
Any such adjustment shall be automatic and shall not require any further action
on the part of the Corporation (except for the preparation of an Adjustment
Certificate pursuant to Section 5.4) or of any registered owner of Class B
Convertible Preferred Stock.

     (b)  Sale or Issuance of Common Stock.  If and whenever the Corporation
          --------------------------------
issues or sells, or in accordance with paragraph (c) of this Section 5.3 is
deemed to have issued or sold, any shares of its Common Stock for consideration
per share less than One Dollar ($1.00) (hereafter, the "Adjustment Trigger
Price"), then immediately upon such issuance or sale (or deemed issuance or
sale) the Conversion Rate then in effect shall be increased by multiplying such
Conversion Rate by a fraction, the numerator of which shall be the sum of (i)
the number of shares of Common Stock outstanding immediately prior to such
issuance or sale (or deemed issuance or sale) plus (ii) the number of shares of
Common Stock so issued or sold (or deemed issued or sold), and the denominator
of which shall be the sum of (x) the number of shares of Common Stock
outstanding immediately prior to such issuance or sale (or deemed issuance or
sale) plus the number of shares of Common Stock that the aggregate consideration
received by the Corporation (or deemed received by the Corporation) in
connection with such issuance or sale (or deemed issuance or sale), determined
in accordance with Subsection 5.3(e) hereof, would purchase at a price per share
equal to the Adjustment Trigger Price. For purposes of this Section 5.3, the
term "Common Stock" shall include all securities of the Corporation having
characteristics substantially equivalent to those of the Corporation's Common
Stock.

     (c)  Deemed Sale or Issuance of Common Stock. For purposes of this Section
          ---------------------------------------
5.3, the following events shall be deemed an issuance or sale of Common Stock:

          (i)  Issuance of Rights, Warrants or Options. If the Corporation in
               ---------------------------------------
     any manner grants any rights, warrants or options to subscribe for or to
     purchase Common Stock (such rights, warrants or options being herein called
     "Options") and the price per share for which Common Stock is issuable upon
     the exercise of such Options is less than the Adjustment Trigger Price,
     then the total maximum number of shares of Common Stock issuable upon the
     exercise of such Options shall be deemed to have been issued and sold by
     the Corporation upon the grant of such Options for such price per share.
     For purposes of this paragraph, the "price per share for which Common Stock
     is issuable" will be determined by dividing (x) the total amount, if any,
     received or receivable by the Corporation as consideration for the granting
     of such Options, plus the minimum aggregate amount of additional
     consideration payable to the Corporation upon the exercise of all such
     Options, by (B) the total maximum number of shares of Common Stock issuable
     upon the exercise of all such Options. No further adjustment of the
     Conversion Rate shall be made when shares of Common Stock are actually
     issued upon the exercise of such Options.

          (ii) Issuance of Convertible Securities.  If the Corporation in any
               ----------------------------------
     manner issues or sells any securities convertible into or exchangeable for
     Common Stock (such convertible or exchangeable

                                       3
<PAGE>

     securities being herein called "Convertible Securities") and the price per
     share for which Common Stock is issuable upon such conversion or exchange
     is less than the Adjustment Trigger Price, then the total maximum number of
     shares of Common Stock issuable upon the conversion or exchange of such
     Convertible Securities shall be deemed to have been issued and sold by the
     Corporation for such price per share upon the issuance or sale of such
     Convertible Securities. For purposes of this paragraph, the "price per
     share for which Common Stock is issuable" shall be determined by dividing
     (x) the total amount received or receivable by the Corporation as
     consideration for the issuance or sale of such Convertible Securities, plus
     the minimum aggregate amount of additional consideration, if any, payable
     to the Corporation upon the conversion or exchange thereof, by (y) the
     total maximum number of shares of Common Stock issuable upon the conversion
     or exchange of all such Convertible Securities. No further adjustment of
     the Conversion Rate shall be made when shares of Common Stock are actually
     issued upon the conversion or exchange of such Convertible Securities.

          (iii)  Treatment of Expired Options and Unexercised Convertible
                 --------------------------------------------------------
     Securities. Upon the expiration of any Option or the termination of any
     ----------
     right to convert or exchange any Convertible Securities without exercise of
     the underlying option or right, provided such Options or Convertible
     Securities are not reissued by the Corporation, the Conversion Rate then in
     effect hereunder will be adjusted to the Conversion Rate that would have
     been in effect at the time of such expiration or termination had such
     Option or Convertible Security, to the extent outstanding immediately prior
     to such expiration or termination, never been issued.

          (iv)   Integrated Transactions.  In case any Option is issued in
                 -----------------------
     connection with the issuance or sale of other securities of the Corporation
     together comprising one integrated transaction in which no specific
     consideration is allocated to such Option by the parties thereto, the
     Option shall be deemed to have been issued for a consideration of One Cent
     ($0.01).

     (d)  Certain Events Excepted.  Notwithstanding the other provisions of this
          -----------------------
Section 5.3, the following events shall not trigger an adjustment to the
Conversion Rate:

          (i)    the issuance or sale (or deemed issuance or sale) of Common
     Stock reserved for issuance in connection with the conversion of Class B
     Convertible Preferred Stock or Class A Convertible Preferred Stock;

          (ii)   the issuance or sale (or deemed issuance or sale) of Common
     Stock reserved for issuance upon the exercise of warrants held by holders
     of the Class B Convertible Preferred Stock or Class A Convertible Preferred
     Stock; and

          (iii)  the grant of Options, or the issuance or sale (or deemed
     issuance or sale) of Common Stock, to officers, employees, directors,
     consultants or advisors of the Corporation pursuant to any stock option
     plan or restricted stock purchase plan adopted by the Corporation or
     Options exercisable after the resignation or termination of any such
     persons.

     (e)  Calculation of Consideration Received. If any Common Stock, Option or
          -------------------------------------
Convertible Security is issued or sold, or deemed to have been issued or sold,
for cash, the consideration received therefor shall

                                       4
<PAGE>

be deemed to be the net amount of cash received by the Corporation therefor. In
case any Common Stock, Option or Convertible Security is issued or sold for a
consideration other than cash, the amount of the consideration other than cash
received by the Corporation shall be the fair market value of such
consideration. If any Common Stock, Option or Convertible Security is issued in
connection with any merger in which the Corporation is the surviving
corporation, the amount of consideration therefor shall be deemed to be the fair
market value of such portion of the net assets and business of the non-surviving
corporation as is attributable to such Common Stock, Option or Convertible
Security, as the case may be. The fair market value of any consideration other
than cash and securities shall be determined by the Board of Directors of the
Corporation.

     (f)  Dividend in Common Stock. If the Corporation pays a dividend in shares
          ------------------------
of its Common Stock, the Conversion Rate shall be increased by multiplying the
Conversion Rate then in effect by a fraction, the numerator of which shall be
the sum of (A) the number of shares of Common Stock outstanding at the opening
of business on the date fixed for such dividend plus (B) the total number of
shares constituting such dividend, and the denominator of which shall be the
number of shares of Common Stock outstanding at the opening of business on the
date fixed for such dividend.

     (g)  Subdivision or Combination of Common Stock. If the Corporation at any
          ------------------------------------------
time subdivides (by any stock split, stock dividend, recapitalization or
otherwise) the outstanding shares of Common Stock into a greater number of
shares, the Conversion Rate and the Adjustment Trigger Price in effect
immediately prior to such subdivision will be, respectively, proportionately
increased and decreased. If the Corporation at any time combines (by reverse
stock split or otherwise) the outstanding shares of Common Stock into a smaller
number of shares, the Conversion Rate and the Adjustment Trigger Price in effect
immediately prior to such combination will be, respectively, proportionately
decreased and increased.

     (h)  Waiver of Automatic Adjustment. An automatic adjustment to the
          ------------------------------
Conversion Rate or the Adjustment Trigger Price pursuant to this Section 5.3 may
not be waived except by written notice to the Corporation executed by the
registered owners of 100 percent of then outstanding shares of Class B
Convertible Preferred Stock.

     5.4  Adjustment Certificate. The Treasurer or Chief Financial Officer of
          ----------------------
the Corporation shall compute all required adjustments to the Conversion Rate or
the Adjustment Trigger Price under this Section 5 and shall prepare a
certificate setting forth the adjusted Conversion Rate or Adjustment Trigger
Price and showing in detail the facts upon which the adjustment was based (the
"Adjustment Certificate"). The Treasurer or Chief Financial Officer shall
promptly file the Adjustment Certificate with the Transfer Agent, if any, for
the Class B Convertible Preferred Stock and shall promptly mail a copy of the
Adjustment Certificate to each record holder of Class B Convertible Preferred
Stock.

     5.5  Notice of Certain Events. In case:
          ------------------------

          (i)    the Corporation shall declare a dividend payable in Common
     Stock;

          (ii)   of any capital reorganization of the Corporation,
     reclassification of the capital stock

                                       5
<PAGE>

     of the Corporation, consolidation or merger of the Corporation with or into
     another corporation, or conveyance of all or substantially all of the
     assets of the Corporation to another corporation; or

          (iii)  of the voluntary or involuntary dissolution, liquidation or
     winding-up of the Corporation;

then, and in any such case, the Corporation shall cause to be mailed to the
Transfer Agent, if any, for the Class B Convertible Preferred Stock and to the
record holders of the outstanding shares of Class B Convertible Preferred Stock,
at least twenty days prior to the record date for any such event, a notice
disclosing the event to occur and the record date for determination of the
stockholders entitled to participate in such event.

     5.6  Common Stock Reserve. The Corporation shall at all times reserve and
          --------------------
keep available, out of its authorized but unissued Common Stock, solely for the
purpose of effecting the conversion of the shares of Class B Convertible
Preferred Stock, the full number of shares of Common Stock issuable upon the
conversion of all shares of Class B Convertible Preferred Stock from time to
time outstanding.

     5.7  Taxes. The Corporation shall pay any and all issue taxes that may be
          -----
payable in respect of the issuance or delivery of shares of Common Stock upon
conversion of shares of Class B Convertible Preferred Stock.

6.   RESTRICTIONS AND LIMITATIONS ON CORPORATE ACTION

     The approval by vote of the holders of at least a majority of the
outstanding shares of Class B Convertible Preferred Stock, voting as a single
class, each share of Class B Convertible Preferred Stock to be entitled to one
vote in each instance, shall be required for any action by the Corporation or
any amendment to the corporate charter if such corporate action or amendment
would change or limit any of the rights, preferences, or privileges of the Class
B Convertible Preferred Stock; provided, however, that the Board of Directors of
the Corporation shall have the authority to authorize the creation and issuance
of a class or series of capital stock having rights, preferences or privileges
senior to or on parity with the Class B Convertible Preferred Stock.

7.   NO IMPAIRMENT

     The Corporation will not, by amendment of its corporate charter or through
any reorganization, transfer of capital stock or assets, consolidation, merger,
dissolution, issue or sale of securities, or through any other voluntary action,
avoid or seek to avoid the observance or performance of any of the terms of the
Class B Convertible Preferred Stock, but will at all times in good faith assist
in the carrying out of all such terms.

8.   NO REISSUANCE OF CLASS B CONVERTIBLE PREFERRED STOCK; TERMINATION

     No share or shares of Class B Convertible Preferred Stock acquired by the
Corporation by reason of conversion or otherwise shall be reissued, and all such
shares shall be canceled, retired and eliminated from the shares which the
Corporation is authorized to issue. Upon the cancellation of all outstanding
shares of the Class B Convertible Preferred Stock, these charter

                                       6
<PAGE>

provisions regarding the Description and Designation of Class B Convertible
Preferred Stock shall terminate and have no further force and effect.

     THIRD: Except as otherwise provided by express provisions of these Articles
Supplementary, nothing herein shall limit, by inference or otherwise, the
discretionary right of the Board of Directors to classify and reclassify and
issue any shares of Preferred Stock and to fix or alter all terms thereof to the
full extent provided in the Charter of the Corporation.

     FOURTH: In addition to the above provisions with respect to the Class B
Convertible Preferred Stock, such Class B Convertible Preferred Stock shall be
subject to, and entitled to the benefits of, the provisions set forth in the
Corporation's Charter with respect to Preferred Stock generally.

     FIFTH: The Board of Directors of the Corporation, pursuant to a Unanimous
Written Consent in Lieu of Meeting dated February 29, 2000, duly authorized and
adopted resolutions classifying and designating the Class B Convertible
Preferred Stock as set forth in these Articles Supplementary.

     IN WITNESS WHEREOF, PharmaKinetics Laboratories, Inc., has caused these
Articles of Supplementary to be signed and acknowledged in its name and on its
behalf by its President and corporate seal to be hereunto affixed and attested
by its Secretary on the 17th day of April, 2000.

ATTEST:                                 PHARMAKINETICS LABORATORIES, INC.

/s/ Taryn L. Kunkel                     By: /s/ James M. Wilkinson, II   (SEAL)
---------------------------                -----------------------------
Secretary                               President

     The undersigned, President of PharmaKinetics Laboratories, Inc., who
executed on behalf of said Corporation the foregoing Articles Supplementary to
the Charter, of which this Certificate is made a part, hereby acknowledges, in
the name and on behalf of the Corporation, the foregoing Articles Supplementary
to be the corporate act of said Corporation, and further certifies that, to the
best of his knowledge, information and belief, the matters and facts set forth
therein with respect to the authorization and approval thereof are true under
the penalties of perjury.

Dated April 17, 2000          /s/ James M. Wilkinson, II
                              ---------------------------------------
                              President

                                       7

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