Document:

<PAGE>
May 7, 2002

Eric Hertz

Dear Eric:

This letter (the "Letter Agreement") sets forth the terms of your employment
with Western Wireless Corporation ("WWC"), effective May 10, 2002 (or date of
execution).

     1.  ROLE: Your title will be Chief Operating Officer. In that capacity you
         will report to the Chief Executive Officer of WWC (the "CEO").

     2.  RESPONSIBILITIES: Your responsibilities will include supervision of all
         operating functions of WWC including sales and marketing, customer
         service, information technology and engineering together with such
         other duties as may be assigned to you by the CEO. You will devote
         substantially all of your business time and attention to the
         obligations delineated in this Letter Agreement.

     3.  CASH COMPENSATION: Your base compensation will be $325,000, payable in
         accordance with standard payroll practices of WWC. In addition, you
         will have an opportunity, as determined by WWC, to earn a performance
         bonus targeted at $225,000 per year, to be paid annually at yearend.
         The bonus will be based on a formula based on growth, cash flow and
         leadership. Your first year's bonus will be prorated for your start
         date. It is understood that nothing contained herein will prevent WWC,
         in its sole and absolute discretion, from, at any time, increasing your
         compensation, either permanently or for a limited period, whether in
         base compensation, by bonus or otherwise, if WWC in its sole
         discretion, shall deem it advisable to do so in order to recognize and
         fairly compensate you for the value of your services to WWC; provided,
         however, that nothing contained in this paragraph three shall in any
         manner obligate WWC to make any such increase or provide any such
         additional compensation or benefits.

     4.  STOCK OPTIONS: You will receive an option to purchase 100,000 shares of
         WWC's common stock at an exercise price per share as of the closing
         price of the stock on your acceptance of this offer or other mutually
         agreed upon date. Your options will have a 4-year vesting and shall
         contain Change of Control protection consistent with other officers of
         WWC. You will be eligible to continue, during the course of your
         employment, to participate in the option program at a level to be
         determined by the CEO and the Compensation Committee.

     5.  RESTRICTED STOCK GRANT: You will receive a restricted stock grant of
         35,000 shares and a cash tax gross up upon your start. The shares will
         be fully vested when granted but subject to forfeiture if you terminate
         your employment voluntarily without Cause or your employment is
         terminated by WWC with Cause prior to your one year anniversary with
         WWC. This forfeiture restriction will terminate if there is a Change of
         Control of WWC. For the purposes of this Letter Agreement, "Change of
         Control" shall be as defined in the WWC Stock Option Agreement.

     6.  RELOCATION: We will pay you a flat payment of $200,000, which is
         intended to cover your costs of relocation including moving your
         belongings, vehicles and animals, the costs associated with buying and
         selling houses and any other costs associated with the move. This
         payment is intended to cover all costs of relocation except that it is
         understood that the company will separately reimburse you for the cost
         of travel to and from Seattle prior to your relocation, the cost of
         temporary housing in the Seattle area and the cost of house hunting
         trips for your family to come to the Seattle area.

     7.  BENEFITS: You will also be eligible to participate in the WWC's
         Employee Benefit Programs upon eligibility, which includes a group
         health insurance program; life insurance and 401(k) plan with matching.

<PAGE>
Page 2

         You will be entitled to four weeks of vacation annually.

     8.  EXPENSES: WWC will reimburse you for all reasonable out-of-pocket
         business expenses paid or incurred by you in connection with the
         performance of your duties, upon submission of signed, itemized lists
         of such expenses on general forms established for that purpose by WWC.

     9.  INDEMNIFICATION: WWC will enter into an Indemnification Agreement with
         you pursuant to which WWC will agree to indemnify you against certain
         liabilities arising by reason of your affiliation with WWC.

     10. NON-DISCLOSURE: You agree not to disclose at any time, whether during
         the term of this Letter Agreement or thereafter, any secret or
         confidential information relating to WWC's or any of its subsidiaries'
         businesses, financial condition or prospects, which information you
         have obtained while employed by WWC or by any of its subsidiaries or
         any of the predecessors in interest of any of them, except (i) as may
         be required in furtherance of the businesses of WWC or of any of its
         subsidiaries, (ii) with WWC's express prior written consent, (iii) if
         such information is made generally available to the public through no
         fault of yours, or (iv) if such disclosure is required by applicable
         law or regulation or by legal process and then only with prompt written
         notice to WWC in advance of any such disclosure.

     11. NON-COMPETE: You agree that, during the term of your employment by WWC
         and for a period of one (1) year immediately following the termination
         of your employment with WWC for any reason whatsoever, you will not,
         either directly or indirectly, for compensation or any other
         consideration, individually or as an employee, broker, agent,
         consultant, lender, contractor, advisor, solicitor, stockholder
         (provided that ownership of 5% or less of the outstanding stock of any
         corporation listed on a national securities exchange is not
         prohibited), proprietor, partner, or person having any other material
         economic interest in, affiliated with or rendering services to any
         other entity, engage in or provide services to or for a business that
         is substantially the same as or similar to WWC's or its subsidiaries
         businesses and which competes within the applicable commercial mobile
         radio services markets serviced by WWC or its subsidiaries, directly or
         indirectly.

     12. EMPLOYMENT AT WILL: Notwithstanding any other provision of this Letter
         Agreement, your employment by WWC may be terminated by WWC at any time,
         with or without Cause, as defined below. In the event of a termination
         for Cause you will have no rights to severance payments. Termination
         for "Cause" means (i) your gross neglect or willful material breach of
         your principal employment responsibilities or duties, (ii) a final
         judicial adjudication that you are guilty of a felony, (iii) fraudulent
         conduct as determined by a court of competent jurisdiction in the
         course of your employment with WWC or any of its subsidiaries, (iv) the
         breach by you of the covenant set forth in paragraph nine, below, or
         (v) the material breach by you of any other provision of this Letter
         Agreement which continues uncured for a period of thirty (30) days
         after notice thereof by WWC. In the event of your voluntary termination
         of employment with WWC, you will have no rights to severance benefits.

         In the event of an involuntary termination for other than Cause (which
         shall include your resignation as a direct result of (i) a reduction in
         your base compensation and/or incentive bonus target percentage, or
         (ii) the material breach by the Company of any provision of this Letter
         Agreement which continues uncured for a period of thirty (30) days
         after notice thereof by you), then (A) you will be entitled to receive
         a severance payment in an amount equal to your accrued but unpaid
         existing annual targeted incentive bonus through the date of
         termination, twelve (12) months of your then base compensation and an
         amount equal to twelve (12) months of your existing annual targeted
         incentive bonus; (B) WWC will, at its expense, make all COBRA benefit
         payments on behalf of you and your dependents for twelve (12) months
         following such involuntary termination; and (C) with respect to any
         stock options previously granted to you by WWC which remain unvested at
         the time of the involuntary termination, notwithstanding the vesting
         language in the stock option agreement pursuant to which such options
         were granted, there shall be immediate vesting

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Page 3

         of that portion of each such grant of unvested stock options as equals
         the product of the total number of such options under such grant which
         remain unvested multiplied by a fraction the numerator of which is the
         sum of (i) the number of days from the date on which the last vesting
         of options under such grant took place to and including the date on
         which the termination occurs plus (ii) 365 and the denominator of which
         is the number of days remaining from the date on which the last vesting
         of options under such grant took place to and including the date on
         which the final vesting under such grant would have occurred.

         Your death or permanent disability will be deemed an involuntary
         termination for other than Cause. "Permanent disability" shall mean
         your inability substantially to render the services required hereunder
         for eight (8) months in any eighteen (18) month period because of a
         physical or mental condition, it being understood that until you have
         received notice from WWC terminating this Letter Agreement, you will
         continue to receive your base compensation and all other benefits to
         which you are entitled under this Letter Agreement.

         You agree that upon termination of your employment by WWC for any
         reason you will surrender to WWC all proprietary records, lists and
         other documents obtained by you or entrusted to you during the course
         of your employment by WWC, together with all copies of all such
         documents. This Letter Agreement contains the entire agreement between
         you and WWC with respect to your employment by WWC, other than human
         resource and corporate policies, which are to be executed by all
         employees. This Letter Agreement may not be amended, waived, changed,
         modified or discharged except by an instrument in writing executed by
         or on behalf of you and WWC.

     13. NOTICES: All notices, requests, demands and other communications with
         respect to this Letter Agreement will be in writing and will be deemed
         to have been duly given if delivered by hand, registered or certified
         mail (first class postage and fees prepaid, return receipt requested),
         telecopier or overnight courier guaranteeing next-day delivery, as
         follows:

         Western Wireless Corporation
         3650 - 131st Avenue SE, #400
         Bellevue, Washington 98006
         Attention:  General Counsel
         Telecopy:  (425) 586-8102

         Eric Hertz

         and to such other persons as either you or WWC has specified in writing
         to the other by notice as aforesaid.

     14. ENFORCEMENT: If any part of this Letter Agreement is hereafter
         construed to be invalid or unenforceable in any jurisdiction, the same
         will not affect the remainder of the Letter Agreement or the
         enforceability of such part in any other jurisdiction, which will be
         given full effect, without regard to the invalid portions or the
         enforceability in such other jurisdiction. If any part of this Letter
         Agreement is held to be unenforceable because of the scope thereof, you
         and WWC agree that the court making such determination will have the
         power to reduce the duration and/or area of such provision and, in its
         reduced form, said provision shall be enforceable; provided, however,
         that such court's determination will not affect the enforceability of
         this Letter Agreement in any other jurisdiction beyond such court's
         authority.

     15. JURISDICTION: This Letter Agreement will be governed by and construed
         and interpreted in accordance with the laws of the State of Washington
         without reference to conflicts of laws principles.

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Page 4

Please signify your acceptance of the terms of this Letter Agreement by signing
where indicated below.

                                            Sincerely yours,

                                            WESTERN WIRELESS CORPORATION

                                            By:
                                               ---------------------------------
                                                    John W. Stanton
                                                    Chief Executive Officer
AGREED TO AND ACCEPTED:

---------------------------------
Eric Hertz<PAGE>
                                                                   EXHIBIT 10.52

[Confidential treatment is being sought for certain portions of this Exhibit, as
indicated by a "[*]" symbol and footnoted as "omitted pursuant to Rule 24b-2 and
filed separately with the Commission." Such omitted portions have been filed
with the Securities and Exchange Commission.]

                       MANUFACTURING AND SUPPLY AGREEMENT

        This Agreement is made this 26th day of June, 2002 by and between Sonus
Pharmaceuticals, Inc., a Delaware corporation having a principal place of
business at 22026 20th Avenue S.E., Bothell, Washington 98021 ("Sonus") and
Gensia Sicor Pharmaceutical Sales, Inc., a Delaware corporation having a
principal place of business at 19 Hughes, Irvine, California 92618-1902 ("Gensia
Sicor").

                                 R E C I T A L S

        WHEREAS, Sonus is developing S-8184, also known as TOCOSOL(TM)
Paclitaxel, a cancer therapy product; and

        WHEREAS, Gensia Sicor is in the business of developing, manufacturing,
testing packaging, and marketing sterile injectable pharmaceutical products; and

        WHEREAS, Sonus desires that Gensia Sicor manufacture and supply Sonus
with certain of its requirements for S-8184; and

        WHEREAS, Gensia Sicor desires to provide services to Sonus related to
the manufacture of S-8184 as agreed to by both parties in accordance with the
terms and conditions set forth herein

        NOW THEREFORE, in consideration of the premises and the mutual promises
and agreements contained herein, Sonus and Gensia Sicor agree as follows:

<PAGE>
1.  DEFINITIONS.

        1.1 "Active Pharmaceutical Ingredient" or "API" means any component of
the Product that is intended to furnish pharmacological activity or other direct
effect in the diagnosis, cure, mitigation, treatment, or prevention of disease,
or to affect the structure or any function of the body of man or animals, but
does not include intermediates used in the synthesis of such ingredients.

        1.2 "API Specifications" means the specifications for the API set forth
in the Master Batch Record. A complete copy of the API Specifications, as agreed
by the parties, is set forth in the API and Excipients Specifications attached
as Exhibit A hereto.

        1.3 "Affiliate" means, with respect to either party, all entities which,
directly or indirectly, are controlled by, control, or are under common control
with such party. For purposes of this definition, the word "control" shall mean
ownership of more than fifty percent (50%) of the voting shares or interest of
an entity.

        1.4 "Batch" means the entire amount of Product yielded from a
manufacturing event using a specific quantity of API, Excipients, and components
Processed in accordance with the Master Batch Record.

        1.5 "Batch Processing Charge" means the pricing set forth in Exhibit J,
including the line batch charge, unit charge, compounding surcharge, and filter
surcharge, as may be adjusted from time to time according to the terms and
conditions set forth herein.

        1.6 "Batch Record" means the document created as and after each Batch is
Processed and Packaged. Each Batch Record shall reflect and incorporate all
aspects of the Master Batch Record, the applicable Certificate of Analysis, and
any Manufacturing Variance Reports issued with respect to such Batch.

        1.7 "Batch Release" means the final sign-off by Gensia Sicor's Quality
Department marking the culmination of the quality process by which a batch of
Product is shown to conform to all aspects of the Manufacturing Standards.

        1.8 "Compounded Bulk" means API and Excipients that have been compounded
but not filled or packaged or finished into a final dosage presentation.

        1.9 "Certificate of Analysis" means a certificate that accompanies each
shipment of API, Excipient or Product certifying that the API, Excipient or
Product meets the specifications as set forth in the Master Batch Record.

        1.10 "Current Good Manufacturing Practices" or "cGMPs" means the current
good manufacturing practices applicable to the manufacture of sterile
pharmaceutical products for human use in the United States, as set forth in
regulations promulgated by the FDA.

        1.11 "Date of Manufacture" means the date of sterile filling of the
Compounded Bulk.

        1.12 "Excipient" means any substance, other than the API, used in
formulating the Product.

                                       2
<PAGE>
        1.13 "Excipient Specification" means the specifications for the
Excipient as set forth in the Master Batch Record. A complete copy of the
Excipient Specifications, as agreed by the parties, is set forth in the API and
Excipients Specifications attached as Exhibit A hereto.

        1.14 "Facility" means Gensia Sicor's facility in Irvine, California, or
any other Gensia Sicor facility as agreed to in writing, in advance, by the
Parties to this Agreement.

        1.15 "FDA" means the United States Food and Drug Administration.

        1.16 "Forecast" means a rolling twelve (12) month estimate of expected
orders for the Product to assist Gensia Sicor in production planning.

        1.17 "Manufacturing Standards" means the specifications for Processing,
Packaging, and storing the Product set forth in the Product Specifications, the
Master Batch Record, cGMPs, MSDSs, and all other applicable U.S. laws and
regulations, to the extent such terms and conditions are not inconsistent with
this Agreement.

        1.18 "Manufacturing Variance Report" means a written report indicating
any Variance in the Processing or Packaging of a Batch from the procedures set
forth in the Master Batch Record.

        1.19 "Master Batch Record" means the document, as may be amended from
time to time, specifying: (i) the API and Excipient Specifications, (ii) the
procedures for testing and releasing the API and Excipients, (iii) the Primary
Components, (iv) Secondary Packaging, (v) the Product Specifications, (vi) the
formula (listing the API and the Excipients for the Product), (vii) the
procedures for manufacturing the Product (listing the API, the Excipients, the
Primary Components, and the Secondary Packaging), and (viii) the procedures for
assuring the quality of the Product.

        1.20 "Master Forecast" means a [ * ] forecast provided to Gensia Sicor
for commercial product manufacturing.

        1.21 "MSDS" means the Material Safety Data Sheets for the API,
Excipients and the Product, respectively.

        1.22 "Package" or "Packaging" means the act of inspecting, labeling, and
packing the Product into saleable units.

        1.23 "Primary Components" means the vial, stopper, and seal as
identified in the Master Batch Record.

        1.24 "Process", "Processed" or "Processing" means the pharmaceutical
manufacturing procedures, or any part thereof, involved in manufacturing the
Product in accordance with the Master Batch Record.

        1.25 "Product" means the finished emulsion cancer therapeutic product
known as TOCOSOL(TM) Paclitaxel.

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       3
<PAGE>
        1.26 "Product Specifications" means the specifications for the Product,
including the Primary Components, the Secondary Packaging, and the in-process
and release specifications for the Product, as set forth in the Master Batch
Record and as may be amended by the parties from time to time. A complete copy
of the Product Specifications, as agreed by the parties, is set forth in the
Product Description and Specifications attached as Exhibit B hereto.

        1.27 "Purchase Order" means the document provided by Sonus to Gensia
Sicor which shall set forth, subject to the terms of this Agreement, the number
of Batches or units to be Processed and Packaged, the estimated Batch Processing
Charge, the requested dates and locations for delivery, and special instructions
for each Batch.

        1.28 "Reference Standard" means a quantity of API or Excipient with a
known assay, with which Gensia Sicor may perform comparative analysis to API or
Excipient samples having an unknown assay.

        1.29 "Registration Batch" means a batch of Product manufactured to
support an NDA filing.

        1.30 "Secondary Packaging" means any component other than Primary
Components used to convert units of Product into saleable units.

        1.31 "Shipping Components" means the packaging, boxes, and shipping
containers into which the Product is placed for shipment to Sonus.

        1.32 "Validation Batch" means a batch of saleable product manufactured
prior to NDA approval to confirm that the process set forth in the NDA is
reproducible at commercial scale, and which meets FDA requirements for a
validation process.

        1.33 "Variance" means a departure from an established quality standard
(including, without limitation, cGMPs or other standard operating procedures,
manufacturing work orders, Packaging orders, raw material or Product
Specifications, analytical control procedures, water monitoring procedures,
equipment maintenance schedules), whether anticipated or unanticipated, which
has the potential to affect the safety, identity, strength, quality or purity of
the Product.

        1.34 "Work in Process" or "WIP" means the API, Excipients, Primary
Components, and Secondary Packaging that constitute a Batch, during the time
period beginning with Gensia Sicor dispensing API in accordance with the Master
Batch Record and ending on the Gensia Sicor release date with respect to such
Batch.

                                       4
<PAGE>
2. ACQUISITION OF MANUFACTURING EQUIPMENT. Promptly after the execution of this
Agreement, the parties shall confer and agree upon a list of the parts and
equipment to be procured by Gensia Sicor on behalf of Sonus for the
manufacturing of the Product. Sonus shall own all of such equipment so acquired.
Gensia Sicor shall maintain customary insurance for the loss or damage to such
equipment which shall name Sonus as a loss payee. The preliminary list of
equipment to be purchased is set forth in Exhibit C attached hereto, which shall
be finalized upon agreement of representatives of Sonus and Gensia Sicor. Gensia
Sicor shall use commercially reasonable efforts to acquire the equipment and
parts at the most favorable pricing available. All purchases of equipment will
be made on a timely basis as needed and with the prior written approval of Sonus
specifying the equipment and costs related thereto. The anticipated costs of the
equipment are set forth on Exhibit C attached hereto. Sonus shall be responsible
for payment of the purchase price of such equipment and the related
administrative charge payable to Gensia Sicor, as provided in Section 6 below.

3. GENSIA SICOR PRE-COMMERCIAL RESPONSIBILITIES.

        3.1 TECHNOLOGY TRANSFER.

               (a) Sonus shall transfer to Gensia Sicor the technology and
expertise necessary to manufacture and supply the requirements of Sonus for the
Product as provided herein. Sonus shall retain exclusive ownership of all
patent, trademark, trade secret and other intellectual property rights relating
to the technology, manufacturing process and information disclosed to Gensia
Sicor. The parties' respective project representatives shall determine the
analytical methods transfer and confirmation thereof; process evaluation,
confirmation, optimization, and scale-up plan; cleaning validation;
microbiology; method of media fills; component compatibility testing; production
test run and other manufacturing procedures in order to finalize the scope of
work and costs associated therewith. The anticipated costs shall include those
related to such matters as more specifically itemized on Exhibit D attached
hereto. In consideration of the services to be rendered by Gensia Sicor in
connection with the technology transfer, Sonus shall pay to Gensia Sicor the
fees as set forth on Exhibit D attached hereto in accordance with the terms and
provisions of Section 6 below.

               (b) Gensia Sicor will develop a Master Batch Record for the
Product following the technical specifications, methods and know-how provided by
Sonus.

               (c) Sonus will transfer a stability indicating analytical
method(s) for the Product to Gensia Sicor. Such methods will be validated by
Gensia Sicor for their application to the finished Product. Upon Gensia Sicor's
successful confirmation of validated stability indicating methods for Product
Gensia Sicor will be responsible for release of finished dosage Product.

        3.2 PRE-COMMERCIAL MANUFACTURING RESPONSIBILITIES. In connection with
the validation and commercialization of the manufacturing process, the
manufacturing of stability lots and clinical supplies and other pre-commercial
manufacturing of the Product, Gensia Sicor shall have the following duties and
responsibilities:

               (a) Gensia Sicor shall establish manufacturing systems
integration, including Batch Record development, SOP development and
modifications, and raw material data sheet development.

                                       5
<PAGE>
               (b) Gensia Sicor shall assist, as requested by Sonus, in the
development of labeling and packaging for the Product, which will be submitted
in regulatory submissions for the Product.

               (c) Gensia Sicor shall manufacture Registration Batches and
perform process validation, including protocol development, implementation and
final report.

               (d) As mutually defined and agreed by the project teams, Gensia
shall conduct stability studies required for an NDA and other regulatory agency
submittals.

               (e) Gensia Sicor shall provide regulatory support in the form of
CMC documentation; sterility assurance package; process flow, facility narrative
and report on testing.

               (f) Gensia Sicor shall validate and certify the manufacturing
process, including installation qualifications, operational qualifications, and
process qualifications for any new equipment or process used to support the
manufacture of the Product.

               (g) Gensia Sicor shall provide suitable manufacturing
instructions and other manufacturing documentation and manufacturing controls
for NDA submission, as well as other regulatory submissions.

               (h) Gensia Sicor shall conduct material contact and equipment
cleanability studies required to support manufacture of the Product in the
Gensia Sicor manufacturing facility. Gensia Sicor shall complete any necessary
sterility, microbial and pyrogen testing studies, and process validation
studies, and provide Sonus or its representatives and appropriate regulatory
agencies with microbiological data, process validation data, batch documents and
other manufacturing and processing data required for FDA and other regulatory
submissions.

               (i) Gensia Sicor will permit Sonus representatives to conduct
necessary GMP and quality assurance reviews of Gensia Sicor documentation,
including review of Gensia Sicor manufacturing work orders and manufacturing
quality assurance Variances regarding the Product and the facilities in which
the Product will be manufactured. In addition, Gensia Sicor shall host at least
an annual quality assurance review of the Gensia Sicor manufacturing facility.

        In consideration of the pre-commercial manufacturing services to be
provided by Gensia Sicor, Sonus shall pay to Gensia Sicor, the fees set forth on
Exhibit E attached hereto in accordance with the provisions of Section 6 below.

4. SONUS' PRE-COMMERCIAL RESPONSIBILITIES.

        4.1 GENERAL RESPONSIBILITIES. Sonus shall have the following development
duties and responsibilities with respect to the development of the Product:

               (a) Sonus shall promptly communicate to Gensia Sicor any changes
to the Product formulation. In addition, to the extent necessary, Sonus shall
verify that the U.S. Product formulation and associated specifications (modified
as necessary) are acceptable as formulations for foreign countries.

                                       6
<PAGE>
               (b) Sonus shall provide approved API, Excipients and Reference
Standards for the manufacture of pre-validation Product to Gensia Sicor,
according to the provisions set forth in Section 8.3, with Certificates of
Analysis, for formulation studies, stability and clinical supplies,
manufacturing studies, and other needs as reasonably required by Gensia Sicor
for execution of its responsibilities under this Agreement. Sonus shall provide
API, Excipients and Reference Standards to Gensia Sicor at no charge at least
fifteen (15) working days prior to any scheduled manufacture of Product. In the
event that Sonus fails to deliver the quantity of conforming API, Excipients and
Reference Standard required for Gensia Sicor to fulfill its obligations
hereunder, Gensia Sicor shall not be obligated to meet scheduled delivery dates.
API, Excipients and Reference Standard shall conform with the API and Excipient
Specifications of Exhibit A, attached hereto and made a part hereof. Sonus shall
have the right to modify the API and Excipient Specifications from time to time
in its sole discretion, in which event Exhibit A shall be so modified. All costs
associated with implementing changes to the Master Batch Record shall be borne
by Sonus, as per Exhibit G, subparagraph 2.1.

               (c) Sonus shall provide Gensia Sicor with technical data to
enable Gensia Sicor to comply with its obligations under this Agreement. Such
data shall include but not be limited to: (1) Material Safety Data Sheets with
environmental and safety information; and (2) summaries of toxicological and
pharmacological data for API and Excipients in sufficient detail to define
potential hazards, establish employee exposure levels, and establish equipment
cleanability limits.

               (d) Sonus shall perform and be responsible for conducting all
clinical studies necessary to obtain FDA approval and regulatory approval from
health authorities in foreign countries as determined by Sonus in its sole
discretion.

               (e) Sonus shall conduct all research and development and use
commercially reasonable efforts to prepare and submit to the FDA, and regulatory
agencies in such foreign countries as Sonus shall deem appropriate in its sole
discretion, an NDA or other regulatory submission covering the Product, respond
to all questions from the regulatory agencies and take necessary steps to obtain
regulatory agency approvals and maintain the approved NDA or other regulatory
submissions covering the Product.

               (f) Sonus shall develop, proofread and maintain label copy and
artwork for the Product. Sonus shall have complete responsibility for content
and accuracy of labeling for Product provided that all labels and package
inserts shall be developed in accordance with Gensia Sicor's guidelines with
regard to physical dimensions and handling procedures.

               (g) Sonus shall review and approve the Master Batch Record in
writing prior to initiating the manufacture of the Product, at least six (6)
weeks prior to the scheduled manufacture of the batch. Material changes to the
Batch Records shall be made at least six (6) weeks in advance of the manufacture
of the next batch.

                                       7
<PAGE>
5. SCHEDULE.

        Both parties agree to use commercially reasonable efforts to conduct and
complete the activities described in the foregoing Sections 2 through 4 with the
goal of manufacturing the first clinical batch of the Product [ * ], according
to the schedule appended hereto as Exhibit F.

6. PAYMENTS FOR GENSIA SICOR'S PRE-COMMERCIAL SERVICES.

        To reimburse Gensia Sicor for its services and participation in the
pre-commercial product development efforts, Sonus shall pay Gensia Sicor the
following:

        6.1 MANUFACTURING EQUIPMENT. As provided in Section 2 above, Sonus shall
be responsible for payment of the purchase price of all equipment procured by
Gensia Sicor on behalf of Sonus. In addition, Sonus shall pay Gensia Sicor an
administration charge equal to [ * ]of the aggregate purchase price of all parts
and equipment procured by Gensia Sicor for and on behalf of Sonus (excluding
sales and other taxes, shipping, packing and other similar charges). Payment
terms shall be as provided in Section 6.4 below.

        6.2 TECHNOLOGY TRANSFER SERVICES. In consideration for the efforts and
services to be rendered by Gensia Sicor regarding the transfer of manufacturing
technology to Gensia Sicor as provided in Section 3.1 above, Sonus shall pay to
Gensia Sicor the fees and expenses set forth on Exhibit D attached hereto.
Payment terms shall be as provided in Section 6.4 below.

        6.3 PRE-COMMERCIAL SERVICES. In consideration for the pre-commercial
services to be provided by Gensia Sicor to Sonus as provided in Section 3.2
above and as more particularly specified on Exhibit E attached hereto, Sonus
shall pay to Gensia Sicor the amounts set forth on Exhibit E. Payment terms
shall be as provided in Section 6.4 below.

        6.4 PAYMENT TERMS.

               (a) Sonus has paid [ * ] to Gensia Sicor as an advance for the
purchase price of equipment and technology transfer services, which will be
creditable against the acquisition of manufacturing equipment as provided in
Section 6.1 above, and the technology transfer services as provided in Section
6.2 above.

               (b) With respect to payments due to Gensia Sicor for the purchase
of equipment under this Section 6, except as covered by the advance provided for
in subparagraph (a) above, all payment requests shall be submitted by invoice
from Gensia Sicor to Sonus promptly following receipt of an invoice from vendor
of such equipment by Gensia Sicor.

               (c) With respect to payments due to Gensia Sicor for services
under this Section 6, except as covered by the advance provided for in
subparagraph (a) above, [ * ] shall be due upon the initiation of a project and
[ * ] shall be due upon completion and acceptance by Sonus of the work for the
project. Initiation of any work or services on the project shall be authorized
by Sonus in writing prior to the commencement of work by Gensia Sicor. All
payment requests shall be submitted by invoice from Gensia Sicor to Sonus.

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       8
<PAGE>
               (d) Unless otherwise specifically provided, payment terms shall
be net thirty days from the day of the Gensia Sicor invoice. Payment shall be in
U.S. dollars. Terms shall be F.O.B. Gensia Sicor's Irvine, California facility.

        6.5 CHANGES IN PROJECT SCOPE OR ADDITIONAL WORK. If material
unanticipated changes occur in any Product development project or to the Product
specifications, or if unanticipated technical difficulties result in the
requirement for Gensia Sicor to perform material amounts of either additional or
repeat work, or if additional work is required beyond the scope of a Product
development project, which is not caused by the fault or negligence of Gensia
Sicor, Gensia Sicor's reasonable costs for such additional work shall be paid by
Sonus, subject to Sonus' prior written approval. Reimbursement for such
additional work shall be at the rates specified on Exhibit G attached hereto,
plus out-of-pocket costs for reasonable travel and subsistence, materials and
supplies. Gensia Sicor shall provide Sonus with a new or revised scope of work
with cost estimates for such additional work and shall receive the written
approval of Sonus prior to commencing any such additional work. Sonus shall pay
Gensia Sicor within thirty (30) days of receipt of an invoice confirming
completion of such work.

7. REGULATORY MATTERS

        7.1 SONUS' REGULATORY SUBMISSIONS FOR THE PRODUCT. Sonus shall be solely
responsible for preparing and filing a NDA for the Product with the FDA and any
applicable user fees for such, and for other regulatory submissions in such
foreign countries as Sonus in its discretion deems appropriate. Sonus shall own
the NDA and all other regulatory filings. Gensia Sicor agrees to cooperate and
assist Sonus as Sonus may reasonably request in any such filings or submissions.

        7.2 GENSIA SICOR'S MANUFACTURING LICENSES AND PERMITS. Gensia Sicor
shall maintain all regulatory and governmental permits, licenses and approvals
that are necessary for the manufacture of the Product and shipment of the
Product to Sonus. During the term of this Agreement, Gensia Sicor will be
responsible for any reporting of matters regarding the manufacture by Gensia
Sicor of the Product to the FDA, or other applicable regulatory authority, as
the case may be, in accordance with the applicable statutes and regulations. If
any matters are reported directly to the FDA or other applicable regulatory
authority, Gensia Sicor shall concurrently furnish copies of such reports to
Sonus.

        Gensia Sicor shall comply with all applicable laws and regulations,
rules, ordinances, injunctions, orders and decrees, and shall maintain in effect
all required governmental permits, licenses, orders, applications and approvals
regarding the Product and the use of its Facility to Process or Package and
store the Product, and Gensia Sicor shall Process or Package and store the
Product in accordance with all such permits, licenses, applications and
approvals.

        Gensia Sicor shall be responsible to ensure that its Processing and/or
Packaging and testing facilities, equipment and systems meet regulatory
requirements for cGMPs for the United States and European Union. Gensia Sicor
shall be responsible for validation of its Facility, equipment, Processing
and/or Packaging processes as well as testing methods that apply to the Product.
In addition, Gensia Sicor shall be responsible for all necessary education and
training of its employees and contractors in regards to the Facility, equipment,
Processing or Packaging, and testing methods that apply to the Product. The
costs of such training will be borne by Gensia Sicor.

                                       9
<PAGE>
        7.3 MANUFACTURING INSPECTIONS. Gensia Sicor shall be responsible for
handling and responding to any FDA or other regulatory authority inspections
with respect to the manufacture by Gensia Sicor of the Product during the term
of this Agreement. To the extent practicable, Gensia Sicor shall inform Sonus of
such inspections and shall permit a representative of Sonus to be present during
those portions of such inspections that relate to the Product. Gensia Sicor
shall provide to Sonus any information reasonably requested by Sonus and all
information requested by any governmental or regulatory authority concerning any
governmental inspection related to or affecting the Product. To the extent that
Gensia Sicor requires the reasonable assistance of Sonus in order to fulfill its
obligations pursuant to this Section 7.3, Sonus agrees to fully cooperate with
and assist Gensia Sicor.

        7.4 TRANSFER OF REGULATORY SUBMISSIONS. In the event, for any reason,
Gensia Sicor is unable to supply Sonus with the Product pursuant to orders
placed by Sonus hereunder, and shall fail to cure its failure within sixty (60)
days of written notice from Sonus, Gensia Sicor shall promptly cooperate as
reasonably required by Sonus to provide Sonus, or a designated third party of
Sonus, under restrictions of confidentiality, such information, records and
other documentation in Gensia Sicor's possession specifically relating to the
manufacture of the Product as Sonus or such designated third party needs to
supply the Product to Sonus, or which shall be reasonably required to transfer
such records and documents as may be necessary to assure that any regulatory
submissions by Gensia Sicor relating to the Product shall inure to the benefit
of Sonus.

8. MANUFACTURE AND SUPPLY OF PRODUCT.

        8.1 PURCHASE AND SALE OF PRODUCT. Pursuant to the terms and conditions
of this Section 8, Gensia Sicor shall manufacture, sell and deliver Product to
Sonus and Sonus shall purchase from Gensia Sicor at least [ * ] of the annual
worldwide requirements of Sonus for the Product. Sonus shall have the right to
manufacture the Product itself or to appoint third parties to manufacture for up
to [ * ] of the worldwide requirements of Sonus for the Product. In the event
Gensia Sicor is unable to supply Sonus with its requirements as set forth
herein, Sonus shall have the right to itself manufacture or appoint a third
party to manufacture Product. Sonus shall give Gensia Sicor six (6) months'
prior notice in writing if Sonus decides to manufacture or have manufactured the
Product by a third party. Gensia Sicor shall manufacture the Product in
accordance with cGMPs per the approved manufacturing Batch Records and in
accordance with the Product Specifications. The Product Description and
Specifications are attached to this Agreement as Exhibit B and made a part
hereof. Product Specifications may be changed from time to time upon approval by
both parties.

        8.2 GOVERNMENT APPROVALS. Notwithstanding any other provision of this
Agreement, Gensia Sicor shall have no obligation to manufacture, sell or deliver
Product to Sonus for commercial use until Sonus has obtained necessary
government approvals required to manufacture and sell Product in the country
into which the Product is intended to be sold.

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       10
<PAGE>
        8.3 SUPPLY OF API AND EXCIPIENTS. API and Excipients to be used in the
manufacture of the Product, as specified in Exhibit A, shall be
supplied/procured as follows:

----------------- ------------------------------- ------------------------------

                  Clinical and Stability Batches          Validation and
                                                    Post-Validation Manufacture

----------------- ------------------------------- ------------------------------

Excipients        Supplied by Sonus to Gensia     Procured and supplied by
                  Sicor at no cost.  (With the    Gensia Sicor from
                  exception of sterile water      Sonus-approved sources.
                  for injection which shall be
                  supplied by Gensia Sicor)

----------------- ------------------------------- ------------------------------

API               Supplied by Sonus to Gensia     Procured and supplied by
                  at no cost.                     Sonus at no cost to Gensia
                                                  Sicor and to be shipped
                                                  directly to Gensia Sicor
                                                  by vendor.

----------------- ------------------------------- ------------------------------

Responsibility for procurement and supply of the API or Excipients may be
transferred from Sonus to Gensia Sicor at any other time that may be mutually
agreeable to the parties, provided that sufficient lead time is allowed to
procure material for scheduled production batches. Gensia Sicor shall use
commercially reasonable efforts to obtain such API and Excipients at the most
favorable pricing available. Sonus shall reimburse Gensia Sicor for the cost of
such API and Excipients obtained by Gensia Sicor on behalf of Sonus according to
the provisions of Section 8.5 (c), below.

        8.4 MANUFACTURE OF PRODUCT.

               (a) Gensia Sicor shall provide such facilities, equipment, and
services as may be required to perform the Processing, Packaging and handling of
such Product in accordance with the manufacturing and control procedures set
forth in the Master Batch Record and the terms and conditions set forth herein.
Gensia Sicor shall manufacture Product for Sonus from the API and Excipients
supplied by Sonus to Gensia Sicor and /or API and Excipients obtained by Gensia
Sicor as per Section 8.3 above. Gensia Sicor will obtain other materials and
components for production from qualified suppliers approved by Gensia Sicor. To
insure Gensia Sicor's ability to manufacture Product in accordance with Sonus'
orders, Sonus shall provide to Gensia Sicor at Gensia Sicor's manufacturing
plant the API and Excipients at least two weeks prior to the scheduled
manufacturing date. API and Excipients shall be delivered F.O.B. Gensia Sicor's
plant pursuant to no-cost purchase orders issued by Gensia Sicor to Sonus. Sonus
warrants to Gensia Sicor that the API and Excipients supplied to Gensia Sicor
hereunder shall meet the specifications set forth in Exhibit A, as may be
modified from time to time by Sonus, and shall be suitable for use in the
manufacture of Product. The API and Excipients shall be accompanied by a
Certificate of Analysis.

               (b) Any proposed change to the Master Batch Record or Product
Specifications must be approved by both Parties. Any resulting increase or
decrease in Gensia Sicor's production costs shall be supported by documentation
in form and content reasonably satisfactory to Sonus. If Sonus elects to adopt
the revision, the Batch Processing Charge will be increased or decreased by the
amount of such changes in production costs, and the related Schedules will be
amended accordingly.

                                       11
<PAGE>
               (i) If Gensia Sicor determines it is technically unable to comply
        with a proposed revision of the Master Batch Record or the
        Specifications, or if Sonus is unwilling to accept any increase in the
        Batch Processing Charge arising therefrom, Sonus may choose in its sole
        discretion to either withdraw the proposed revision or terminate the
        Agreement.

               (ii) No revisions to the Specifications that would affect the
        Processing and/or Packaging of the Product shall be submitted to any
        Regulatory Authorities unless approved by both Parties in writing. It is
        understood by both Parties that changes mandated by Regulatory
        Authorities shall be acted upon with due diligence.

               (iii) Gensia Sicor shall not change the geographical location at
        which it Processes the Product nor shall it make any material change to
        the facilities used to Process the Product without providing Sonus with
        prior written notification. All costs associated with a facility change
        or modification that is requested by Sonus shall be the responsibility
        of Sonus. All costs associated with a facility change or modification
        that is imposed by the FDA or any other regulatory body to comply with
        cGMP shall be the responsibility of Gensia Sicor, unless such change
        relates solely to, or was caused solely by, the Product.

               (c) Risk of loss of API, Work in-Process and finished Product
held by Gensia Sicor on its premises and in its care, custody and control, shall
be with Gensia Sicor until shipped as Product or otherwise to Sonus, except as
provided for in this Section. Notwithstanding the foregoing, Gensia Sicor shall
not be liable for loss of API, Work in-Process or finished Product when Gensia
Sicor is conducting manufacturing operations in accordance with Gensia Sicor's
SOPs, cGMPs and the procedures as set forth in the Master Batch Record, except
as set forth below.

               (i) In the event of a failed Batch, Gensia Sicor shall be liable
        to Sonus only if the cause of such a failure is attributable primarily
        to the negligence or willful conduct of Gensia Sicor. In that case,
        Gensia Sicor shall, as Sonus' sole and exclusive remedy for the failed
        Batch, not invoice Sonus for the failed Batch and Sonus may choose one
        of the following two options:

               Option 1: Gensia Sicor will pay Sonus an amount equal to the
               lesser of (i) the value of the lost API or (ii) the Line Batch
               Charge as set forth in Exhibit J.

               Option 2: Gensia Sicor will use commercially reasonable efforts
               to remanufacture the Batch as soon as practical, and apply a
               credit to the invoice for the replacement batch in an amount that
               is the lesser of (i) the value of the lost API or (ii) the Line
               Batch Charge as set forth in Exhibit J.

               Notwithstanding the foregoing, if the cause of such a failure is
        due to equipment failure (other than equipment specified by Sonus and
        maintained by Gensia Sicor in accordance with manufacturer's
        recommendations), operator error or accident, Sonus will not be charged
        the Batch Processing Charge.

                                       12
<PAGE>
               Gensia Sicor shall assume no liability for Product that fails to
        conform with the Manufacturing Standards if the Product: (i) has been
        subjected to misuse, negligence or accident other than by Gensia Sicor
        or any employee or agent of Gensia Sicor; (ii) has been stored, handled
        or used by others in a manner contrary to current good manufacturing
        practices or similar requirements after delivery to a common carrier; or
        (iii) nonconformance is attributable to processes, procedures or Product
        components specified by Sonus in the Master Batch Record where such
        processes, procedures or Product components were followed or used by
        Gensia Sicor in accordance with the Master Batch Record

               (ii) In the event of loss of API prior to the start of the
        manufacturing process, Gensia Sicor shall be liable to Sonus only if the
        cause of such a failure is attributable primarily to the negligence or
        willful conduct of Gensia Sicor. In that case, Gensia Sicor shall, as
        Sonus' sole and exclusive remedy for the lost API, pay to Sonus an
        amount that is equal to the value of the lost API.

               (iii) Gensia Sicor shall not be liable for loss of API,
        Compounded Bulk, WIP, or Product; (1) resulting from an event of force
        majeure; (2) caused by Sonus' negligence or willful misconduct; (3)
        [ * ]; or (4) occurring while Gensia Sicor is actually conducting
        manufacturing operations in accordance with the Manufacturing Standards,
        except as specified in subparagraph (e) below.

               (d) Adequate storage space shall be provided for the API,
Excipients and finished Product, on-site at Gensia Sicor. Gensia Sicor shall
maintain and monitor API, Excipients and finished Product temperature where
specified. In the event Sonus requests Gensia Sicor to store Product after it
has been released, Gensia Sicor shall store the Product as storage capacity
allows for a reasonable time at the rates set forth on Exhibit H. Gensia Sicor
will store the Product at no charge for up to fifteen (15) calendar days
following Gensia Sicor Batch Release. In the event that Sonus requires a delay
in shipment of finished Product and Sonus communicates such change in writing
prior to Gensia Sicor Batch Release, Gensia Sicor will either transfer the
Product to a Sonus specified pharmaceutical warehouse or, as space permits,
store the finished Product and invoice Sonus for the Batch(s).

               (e) Normal inventory and yield loss for API and Excipients
("Standard Batch Yield") shall be established by agreement of the parties after
three (3) full validation runs plus three (3) commercial runs of saleable
Product. The Standard Batch Yield shall be reviewed and may be modified on an
annual basis upon mutual consent of the parties taking into consideration Gensia
Sicor's actual manufacturing experience with the Product. In the event that a
commercial batch yields less than the Standard Batch Yield by more than [ * ],
Gensia Sicor shall reimburse Sonus for the cost of the amount of wasted API and
Excipients provided by or paid for by Sonus, at the then current cost, however,
in no event shall reimbursement by Gensia Sicor under this Section 8.4(e) exceed
an amount equivalent to the Line Batch Charge set forth on Exhibit J.

               (f) Product shall be labeled by Gensia Sicor in accordance with
label copy provided by Sonus, which shall have been approved by the appropriate
regulatory agency. Such copy may be modified from time to time by Sonus. All
costs associated with labeling changes shall be borne by Sonus. Product labeling
shall contain the trademarks designated by Sonus. Primary and

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       13
<PAGE>

secondary labeling shall acknowledge and name Gensia Sicor Pharmaceuticals as
the manufacturer of the Product.

               (g) Gensia Sicor's manufacturing process, quality control
procedures, testing and in-plant quality control checks on the production of
Product for Sonus shall be applied in the same manner as those procedures and
checks are applied to other products manufactured by Gensia Sicor and shall
include procedures specified on Exhibit I attached hereto. A Certificate of
Analysis shall be provided to Sonus at the time Product is delivered hereunder.

               (h) Sonus shall have a period of twenty-five (25) days from the
date of receipt by Sonus to inspect and reject any shipment of Product on the
grounds that it does not conform with the Product Description and
Specifications. If the Product is delivered by Gensia Sicor directly to
customers, the inspection period shall be twenty-five (25) days from the receipt
of the Product by the customer. Sonus shall have the right to return any Product
that does not conform. Sonus shall be deemed to have accepted delivery of
Product if no notice of rejection is received by Gensia Sicor in accordance with
the procedure and time frame described herein. No claims with respect to
rejected Product shall be greater than the sum of the cost of replacement of API
or Excipients as set forth in subparagraph (b) above plus the Purchase Order
price for the non-conforming Product. All or part of any shipment may be held
for Gensia Sicor's disposition and at Gensia Sicor's expense if found to be not
in conformance with the Product Specifications, provided Gensia Sicor confirms
such nonconformance through generally accepted quality control procedures, and
provided further that such nonconformance is not due to the failure of the API
or Excipients supplied by Sonus hereunder to conform to the specifications
therefor. If the parties disagree with respect to whether Product is
nonconforming, the Product in question shall be submitted for testing to an
independent testing laboratory acceptable to both parties. The parties further
agree that the determination of such independent laboratory shall be binding on
both parties and that the cost related to such testing shall be paid by the
party that was in error with respect to whether the Product is nonconforming.
Any Product not rejected by Sonus pursuant to this subparagraph 8.4(f) shall be
deemed accepted.

               (i) Sonus shall reimburse Gensia Sicor for the actual cost of any
obsolete Excipients, Primary Components, Shipping Components, and Secondary
Packaging, (plus any related special disposal costs) purchased by Gensia Sicor
expressly to meet its performance obligations under this Agreement in reliance
upon Sonus' then most recent Forecast, except in the case where such obsolete
Excipients, Primary Components, Shipping Components and Secondary Packaging were
purchased by Gensia Sicor greater than three (3) months before scheduled use. An
obsolete component is any Excipient, Primary Component, Secondary Packaging, or
Shipping Component which cannot be incorporated into the Product due to changes
directed by Sonus or mandated by a regulatory authority, or caused by a
cancellation or postponement of manufacturing. Once a component becomes
obsolete, Gensia Sicor may invoice Sonus the acquisition cost of such obsolete
components, which invoice shall identify the Excipients or components in
question and shall be accompanied by a reasonably detailed statement of the
cause of such obsolescence. Any such obsolete component(s) shall be returned to
Sonus and Sonus' discretion and expense.

               (j) If any Product must be recalled by reason of failure to meet
any requirements of any regulatory authority or any other requirements of law or
if an NDA Field Alert must be issued, Sonus shall have the sole responsibility
to effect such recall or issue such Field Alert. Sonus shall consult with Gensia
Sicor prior to effecting any such recall or issuing any such NDA Field Alert.
Gensia Sicor shall cooperate as reasonably required in Sonus' efforts. The
parties shall have the following duties and responsibilities in connection with
any such recall:

                                       14
<PAGE>
        (i)    Sonus' Responsibility.

               If the failure to meet applicable legal requirements resulting in
               a recall or issuance of an NDA Field Alert is not caused by the
               act or omission of Gensia Sicor, then Sonus shall reimburse
               Gensia Sicor for any costs reasonably expended by Gensia Sicor to
               effect the recall. Sonus shall bear the cost of (a) the Batch
               Processing Charge for any Product that is recalled and (b)
               reimburse Gensia Sicor on a time and materials basis not to
               exceed the Batch Processing Charge, for any Work-in-Process,
               Finished but non-approved Product, or Product that cannot be
               shipped due to the condition requiring the recall, provided that
               as of the date that the Processing and/or Packaging was suspended
               as a result of the recall, such Work-in-Process had been
               Processed and/or Packaged in accordance with the Master Batch
               Record and/or Master Packaging Record, and the non-approved
               Product and/or unshipped Product conforms in all material aspects
               to the Specifications and was Processed and/or Packaged in
               accordance with the Processing and/or Packaging, Quality
               Assurance and Validation procedures set forth in the
               Specifications and with any applicable regulations of any
               Regulatory Authorities, including cGMPs.

        (ii)   Gensia Sicor's Responsibility.

               If the failure to meet applicable legal requirements resulting in
               a recall or issuance of an NDA Field Alert is caused by an act or
               omission of Gensia Sicor, or by the breach of Gensia Sicor's
               warranties under this Agreement, or if the Product failed to
               conform to any of the Specifications resulting in a recall or
               issuance of an NDA Field Alert, Gensia Sicor shall reimburse
               Sonus for (a) any cost reasonably expended by Sonus to effect the
               recall or issue the NDA Field Alert, and (b) any Batch Processing
               Charge paid to Gensia Sicor by Sonus for recalled Product and for
               any Product that cannot be shipped due to the condition requiring
               the recall or NDA Field Alert.

        (iii)  Cooperation.

               Gensia Sicor shall cooperate as reasonably required to allow
               Sonus to determine the root cause of the problem resulting in a
               recall or Field Alert. Such assistance shall include follow-up
               investigation including reviews of retained samples and Batch
               Records as well as testing of Product. Gensia Sicor shall provide
               Sonus within five (5) business days from the date of request all
               necessary information that will enable Sonus to respond properly
               to issues relating to the recall or Field Alert. Gensia Sicor
               shall also cooperate fully in resolving Product issues.

               (k) Sonus shall have the right, upon reasonable written notice to
Gensia Sicor, to conduct once each calendar year and during normal business
hours a quality assurance audit and inspection of Gensia Sicor's records and
production facilities relating to manufacture of the Product.

               (l) If requested by the FDA or other regulatory agency, either
party may provide a copy of this Agreement to the FDA or other regulatory agency
with selected financial and business terms redacted. In such event the party
providing the copy shall immediately notify the other party that a copy has been
or will be provided to the FDA or other regulatory agency. The parties further
acknowledge that either party may be required to file this Agreement under
federal securities laws.

                                       15
<PAGE>
               (m) Gensia Sicor shall maintain hazard and liability insurance
which shall cover loss or damage to API or Work in Progress. Wherever loss as
described in this Section 8.4 is covered by insurance held by Gensia Sicor, the
first recourse for recovery of loss shall be through such insurance and to the
full extent of the loss, notwithstanding any other limitations set forth in this
Section 8.4.

               (n) Wherever loss as described in this Section 8.4 is limited to
the amount of the Line Batch Charge as set forth in Exhibit J, that limit shall
be the greater of the current Line Batch Charge or [ * ] which is the Line Batch
Charge as of the date of execution of this Agreement.

        8.5 PRICE AND PAYMENT.

               (a) Product shall be delivered by Gensia Sicor at the prices set
forth in Exhibit J of this Agreement. The pricing set forth on Exhibit J shall
remain in effect from the date of this Agreement through [ * ]. Thereafter, the
pricing may be increased by Gensia Sicor by an amount not to exceed the annual
percentage increase of the Producer Price Index, pharmaceutical preparations,
issued by the Bureau of Labor Statistics, the U.S. Department of Labor. The
pricing includes related services for (i) supplying cGMP compliant facilities,
equipment and processes, (ii) maintenance, calibration and monitoring of all
utility systems, (iii) microbiological monitoring of controlled environments,
(iv) processing supplies, (v) manufacturing production, (vi) one manufacturing
day and necessary labor and resources to support the manufacture of one batch of
Product, (vii) personnel training, (viii) system maintenance of SOPs and Batch
Records, and (ix) completion of Batch Record reviews and product releases within
forty-five (45) days of initiating manufacture. The prices do not include any
labeling or packaging development or other preparatory or other work requested
by Sonus. Gensia Sicor shall invoice Sonus for such labeling and packaging
development or other work according to the pricing set forth on Exhibit E
attached hereto. Gensia Sicor may revise the Batch Processing Charge, upon
written notification to Sonus, should new processes or procedures be required
for the safe manufacture and clean-up of the Product, provided that Gensia
Sicor, Sonus and appropriate vendor(s) will collaborate to minimize such
charges.

               (b) Gensia Sicor shall offer to Sonus the benefit of any
volume-based price adjustments or other discount programs that it makes
available to any other customers for comparable utilization of Gensia Sicor
facilities or resources at the same time as Gensia Sicor provides any such
benefit to its other customers.

               (c) Gensia Sicor shall be responsible for payment of the purchase
price of all API and Excipients procured by Gensia Sicor for and on behalf of
Sonus, except as provided in Section 8.4 (a) and (b). Gensia Sicor shall invoice
Sonus for reimbursement for the aggregate purchase price of all such API and
Excipients procured. In addition, Sonus shall pay Gensia Sicor an administration
charge equal to [ * ] of the aggregate purchase price of all API and Excipients
procured by Gensia Sicor for and on behalf of Sonus (excluding sales and other
taxes, shipping, packing and other similar charges).

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       16
<PAGE>
               (d) In addition, upon request by Sonus, Gensia Sicor shall
provide miscellaneous support services, including Batch Record modification,
excipient testing and Batch Release testing for the prices set forth on Exhibit
G attached hereto.

               (e) Gensia Sicor shall invoice Sonus upon delivery of Product to
Sonus for each batch manufactured by Gensia Sicor the sum of the Batch
Processing Charge as specified on Exhibit J. The price for one batch of Product
includes one manufacturing production day and necessary labor and resources to
manufacture one batch of Product. A late payment service charge of 1.5 percent
per month (or the highest amount permitted by law, if lower than 1.5 percent)
shall be paid on all amounts that are past due more than thirty (30) days from
the date of invoice, which shall not be submitted to Sonus prior to Batch
Release.

               (f) Any federal, state, county or municipal sales or use tax,
excise or similar charge, or any other tax assessment (other than that assessed
against income), license, fee or other charge lawfully assessed or charged on
the sale or transportation of Product sold pursuant to this Agreement shall be
paid by Sonus.

        8.6 DELIVERY. Upon Gensia Sicor's release, the finished Product shall be
shipped to Sonus, or another location specified by Sonus on a corresponding
Purchase Order. Shipping costs, which shall be described as commercial freight
ground service per Gensia Sicor's selected carrier, or the carrier or method of
shipment as specified by Sonus, shall be borne by Sonus. Any additional shipping
costs, including temperature monitors if required, will be borne by Sonus and
will be invoiced at the actual rate, plus any additional out-of-pocket charges
for delivery services. Product shall be delivered to Sonus F.O.B. Gensia Sicor's
facility in Irvine, California and title shall pass to Sonus at such point.
Gensia Sicor will not be liable for loss or damage to the Product resulting from
the shipping of Product subsequent to its delivery to the common carrier.

        8.7 ORDERS AND FORECASTS.

               (a) Upon execution of this agreement, Sonus shall supply Gensia
Sicor with a Forecast for the Product, and update it [ * ]. For clinical Product
Gensia Sicor acknowledges that the Forecast is an estimate and shall not be
binding.

               (b) At least [ * ] prior to the first forecasted commercial sale
of the Product, and thereafter [ * ], Sonus shall supply Gensia Sicor with a
rolling Forecast of the quantities of the Product Sonus intends to order during
the following [ * ] period. Estimated demand for Product shall be communicated
[ * ]. The first [ * ] of the Forecast shall constitute a firm order and a
binding commitment. The last [ * ] of each Forecast shall constitute a good
faith estimate of expected orders for the Product to assist Gensia Sicor with
production planning.

               (c) In addition to a rolling [ * ] Forecast, Sonus shall supply
Gensia Sicor with a Master Forecast on the following schedule:

        1.  [ * ] prior to commercial launch, then;
        2.  Prior to either [ * ], whichever comes first, then;
        3.  [ * ] after the latest submission of the Master Forecast, then;
        4.  Prior to [ * ] in all subsequent years

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       17
<PAGE>
               Sonus' purchase obligation shall be [ * ] of the [ * ] Forecasted
in each Master Forecast. Should the number of [ * ] ordered by Sonus in any
[ * ] be less than [ * ] of the [ * ] forecasted in the Master Forecast, Sonus
shall pay Gensia Sicor [ * ] of the then current [ * ] as set forth in Exhibit J
for each [ * ] not supplied. If any failure to meet the purchase obligation
under the Master Forecast results from cancellation of any order for which a fee
is payable under subparagraph (h) below, the total fee payable for any [ * ] not
supplied shall be [ * ].

               (d) Sonus shall place each Purchase Order with Gensia Sicor for
Product to be delivered hereunder at least [ * ] prior to the requested delivery
date specified in each respective Purchase Order. Gensia Sicor will deliver
written confirmation of receipt of each Purchase Order and the anticipated
delivery date of Product to Sonus within [ * ] of receipt by Gensia Sicor. Sonus
shall be obligated to purchase all Product ordered and delivered by the
specified delivery date.

               (e) Gensia Sicor may reject any Purchase Order that exceeds [ * ]
of the [ * ] forecasted in the Master Forecast. No rejection shall be effective
unless in writing and delivered to Sonus within [ * ] of Gensia Sicor's receipt
of Sonus' Purchase Order. Gensia Sicor will use commercially reasonable efforts
to meet Sonus' requests for [ * ] in excess of those set forth in the Master
Forecast, provided, however, that no breach of this Agreement shall occur if
Gensia Sicor, despite its commercially reasonable efforts, is unable to supply
such quantities of Product to Sonus.

               (f) Each Purchase Order for Product shall be governed by the
terms of this Agreement and none of the provisions of such Purchase Order shall
be applicable except those specifying quantity ordered, delivery dates, special
shipping instructions and invoice information.

               (g) Sonus shall have the right to audit Gensia Sicor's records
during normal business hours, from time to time, to confirm that the provisions
of this Agreement are being applied as specified.

               (h) In the event Sonus cancels or postpones Processing prior to
the manufacturing date communicated to Sonus pursuant to this Section 8.7,
Gensia Sicor shall use commercially reasonable efforts to reschedule the
postponed order to a date agreeable to both Parties. If Sonus does not
reschedule the date of manufacture to a date within [ * ] of the originally
scheduled date, the Purchase Order shall be considered cancelled. Sonus may
postpone a Purchase Order [ * ]. Sonus shall reimburse Gensia Sicor for all
unique supplies and components acquired for Sonus in the event of cancellation
of any manufacturing run. If a manufacturing date is cancelled or postponed by
Sonus, Sonus may be charged a cancellation fee in accordance with the following:

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       18
<PAGE>
----------------------------------------------  --------------------------------

         CANCELLATION / POSTPONEMENT                        FEE

----------------------------------------------  --------------------------------

Notice of cancellation /postponement received   [ * ] as set forth in Exhibit J.
less than [ * ] from the scheduled fill date

----------------------------------------------  --------------------------------

Notice of cancellation / postponement received  [ * ]
less than [ * ] from the scheduled fill date

----------------------------------------------  --------------------------------

Notice of cancellation / postponement received  [ * ]
less than [ * ] from the scheduled fill date

----------------------------------------------  --------------------------------

Notice of cancellation / postponement received  [ * ]
less than [ * ] from the scheduled fill date

----------------------------------------------  --------------------------------

        8.8 WARRANTIES.

               (a) Sonus represents and warrants to Gensia Sicor that API and
Excipients to be delivered to Gensia Sicor pursuant to this Agreement, at the
time of delivery, (i) shall conform to the specifications for such API and
Excipients, and (ii) shall not be adulterated or misbranded within the meaning
of the Federal Food, Drug and Cosmetic Act, as amended, or within the meaning of
any applicable state or municipal law in which the definitions of adulteration
and misbranding are substantially the same as those contained in the Federal
Food, Drug and Cosmetic Act, as well as any applicable foreign law or regulation
of any country in which the Product will be sold, as such Act and such laws are
constituted and effective at the time of delivery and shall not be an article
which may not under the provisions of Sections 404 and 505 of such Act be
introduced into interstate commerce.

               (b) Gensia Sicor represents and warrants to Sonus that Product
delivered to Sonus pursuant to this Agreement shall, at the time of delivery,
not be adulterated or misbranded within the meaning of the Federal Food, Drug
and Cosmetic Act, as amended, or within the meaning of any applicable state or
municipal law in which the definitions of adulteration and misbranding are
substantially the same as those contained in the Federal Food, Drug and Cosmetic
Act, as well as any applicable foreign law or regulation of any country in which
the Product will be sold, as such Act and such laws are constituted and
effective at the time of delivery and shall not be an article which may not
under the provisions of Sections 404 and 505 of such Act be introduced into
interstate commerce.

               (c) Gensia Sicor represents and warrants that Product delivered
to Sonus pursuant to this Agreement shall be manufactured in an FDA approved
facility in accordance with the term of this Agreement and current Good
Manufacturing Practices, as promulgated by the FDA, and shall conform with the
Product Description and Specifications of Exhibit B. Gensia Sicor further
warrants that Product delivered to Sonus pursuant to this Agreement shall be
manufactured in accordance with applicable laws and regulations of regulatory
agencies of other countries in which the Product will be sold. The foregoing
warranties shall not extend to any nonconformity or defect which relates to or
is caused by API or Excipients supplied to Gensia Sicor by Sonus.

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       19
<PAGE>
               (d) NEITHER PARTY MAKES ANY OTHER WARRANTIES, EXPRESS OR IMPLIED,
WITH RESPECT TO THE API, EXCIPIENTS OR THE PRODUCT. ALL OTHER WARRANTIES,
EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF
MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE HEREBY DISCLAIMED BY
GENSIA SICOR. Neither party shall be liable to the other for any indirect,
incidental, special or consequential damages resulting from any breach of this
Agreement.

               (e) Gensia Sicor shall indemnify, defend and hold Sonus harmless
from and against all claims, causes of action, settlement costs, including
reasonable legal expenses, losses or liabilities of any kind asserted by third
persons which arise out of or are attributable to (i) any negligent act or
omission or willful misconduct on the part of Gensia Sicor's employees, agents
or representatives, or (ii) any breach by Gensia Sicor of any term or provision
of this Agreement. Sonus shall indemnify, defend and hold Gensia Sicor harmless
from and against all claims, causes of action, settlement costs, including
reasonable legal expenses, losses or liabilities of any kind asserted by third
persons which (i) arise out of or are attributable to any negligent act omission
or willful misconduct on the part of Sonus' employees, agents or
representatives, or (ii) any breach by Sonus of any term or provision of this
Agreement, or (iii) involve the use of the Product as a pharmaceutical product,
or the safety or efficacy of the Product and which are not otherwise
attributable to any indemnification claim of Sonus pursuant to the preceding
sentence.

               (f) Sonus shall indemnify, defend and hold Gensia Sicor harmless
from and against any damage, judgment, loss, cost or other expense, including
reasonable legal expenses, arising from claims that the Product or its
manufacture, use or sale infringes patent or other proprietary rights of a third
party provided that the infringement does not relate solely to the manufacturing
procedures of Gensia Sicor.

               (g) If either party expects to seek indemnification from the
other under the preceding three subparagraphs, the party seeking indemnification
shall promptly give notice to the other party of any such claim or suit
threatened, made or filed against it which forms the basis for such claim of
indemnification and shall cooperate fully with the other party in the
investigation and defense of all such claims or suits. The indemnifying party
shall have the option to assume the other party's defense in any such claim or
suit with counsel reasonably satisfactory to the other party. No settlement or
compromise shall be binding on a party hereto without its prior written consent,
unless such settlement fully releases the other party without any liability,
loss, cost or obligation to such party.

               (h) In the event (a) any government authority issues a request,
directive or order that the Product be recalled, or (b) any court of competent
jurisdiction order such a recall, or (c) Sonus, after consultation with Gensia
Sicor determines that the Product should be recalled, then in any such event,
the parties shall have the respective duties and obligations set forth in
Section 8.4(j) above, and take all appropriate corrective actions, and shall
cooperate in the investigations surrounding the recall. Sonus shall have the
sole responsibility of notifying customers and return of Product from customers,
as well as all FDA communications and requests regarding any such recalls.

                                       20
<PAGE>

9. TERM AND TERMINATION.

        9.1 This Agreement shall commence on the date first above written and
the initial term shall expire [ * ] following market introduction of the
Product; provided, however, that if market introduction of the Product has not
occurred within [ * ] from the date of this Agreement, either party may
terminate this Agreement upon ninety (90) days prior written notice to the other
party. Thereafter, the term shall continue automatically for successive two (2)
year periods until terminated, upon not less than twelve (12) months prior
written notice from one party to the other.

        9.2 Either party may terminate this Agreement by giving to the other
sixty (60) days prior written notice upon the bankruptcy or the insolvency of
the other party.

        9.3 Either party may terminate this Agreement upon the breach of any
material provision of this Agreement by the other party if the breach is not
cured within sixty (60) days after written notice thereof to the party in
default.

        9.4 Either party may terminate this Agreement with sixty (60) days
written notice should the manufacture of the Product be deemed unfeasible, and
only after commercially reasonable efforts have been applied to resolve the
circumstance that is deemed the cause of the manufacture being unfeasible.
Circumstances that could cause the manufacture of the Product to be deemed
unfeasible include, but shall not be limited to, [ * ] and failure to
manufacture the Product in accordance with the [ * ].

        9.5 Upon any termination of this Agreement, Gensia Sicor shall return to
Sonus all manufacturing equipment and parts, API, Excipients, and other
materials and supplies which Sonus has supplied to Gensia Sicor or has paid for
pursuant to the terms of this Agreement. All such items shall be returned F.O.B.
Gensia Sicor's facility in Irvine, California and Sonus shall be solely
responsible for all packing, shipping and related charges.

        9.6 Termination, expiration, cancellation or abandonment of this
Agreement through any means and for any reason shall not relieve the parties of
any obligation accruing prior thereto and shall be without prejudice to the
rights and remedies of either party with respect to any antecedent breach of any
of the provisions of this Agreement.

10. CONFIDENTIAL INFORMATION.

        It is recognized by the parties that during the term of this Agreement
the parties shall exchange Confidential Information. "Confidential Information"
shall mean all information, including where appropriate without limitation, any
information, patent disclosures, patent applications, structures, models,
techniques, processes, compositions, compounds and apparatus relating to the
same, disclosed by one party (the "disclosing party") to the other party (the
"recipient") or obtained by the recipient through observation or examination of
such information, but only to the extent that such information is maintained as
confidential by the disclosing party. Gensia Sicor acknowledges that all
information relating to the Specifications of the Product and the active
ingredient for the Product, and all manufacturing processes and procedures for
the Product which are disclosed by Sonus to Gensia Sicor, constitute
Confidential Information and are exclusively owned by Sonus. Gensia Sicor agrees
that it shall not disclose Confidential Information received from

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       21
<PAGE>
Sonus, and shall not use Confidential Information disclosed to it by Sonus for
Gensia Sicor's benefit (other than in the performance of its obligations
hereunder) or for the benefit of any third person. Sonus agrees that it shall
not disclose confidential Information received from Gensia Sicor, and shall not
use Confidential Information disclosed to it by Gensia Sicor for Sonus' benefit
(other than in the performance of its obligations hereunder) or for the benefit
of any third person. For purposes of this Agreement, Confidential Information
shall include all information disclosed hereunder in writing and identified as
confidential or if disclosed orally is reduced to writing within thirty (30)
days of oral disclosure and identified as confidential, except any portion
thereof which:

               (a) the recipient can prove was known to the recipient before
receipt hereof under this Agreement;

               (b) is disclosed in good faith to the recipient after acceptance
of this Agreement by a third person lawfully in possession of such information
and not under an obligation of nondisclosure;

               (c) is or becomes part of the public domain through no fault of
the recipient;

               (d) the recipient can prove was developed by the recipient
independently of information disclosed hereunder; or

               (e) is required by law to be disclosed; provided, however, that
no disclosure shall be made pursuant to this clause (e) unless prior notice is
given to the disclosing party and the disclosing party shall have a reasonable
opportunity to prevent such disclosure or take appropriate preventative
precautions relating to such disclosure.

        In the case of clauses (a), (b) and (d) above, the exception must be
proven by clear and convincing evidence and evidence of prior knowledge must be
in the form of a document dated prior to the disclosure by the disclosing party.
Notwithstanding the above, nothing contained in this Agreement shall preclude
Sonus or Gensia Sicor from utilizing Confidential Information as may be
necessary in prosecuting patent rights of the parties with respect to inventions
solely owned by that party, or obtaining governmental marketing approvals for
Product, or in manufacturing Product pursuant to this Agreement. The obligations
of the parties relating to Confidential Information shall expire five (5) years
after the termination of this Agreement.

        The provisions of this paragraph 9 are in addition to the provisions of
the confidential disclosure agreement entered into between Sonus and Gensia
Sicor on May 4, 2001.

                                       22
<PAGE>
11. IMPROVEMENTS.

        11.1 GENSIA SICOR PROCESS IMPROVEMENTS. Any developments, inventions or
discoveries developed or acquired solely by Gensia Sicor during the term of this
Agreement and which are applied to the manufacture of the Product shall be owned
solely by Gensia Sicor ("Gensia Sicor Process Improvements"). Sonus shall have a
royalty-free, non-exclusive, perpetual license to such Improvements relating
solely to the manufacture of the Product, whether such Improvements are
patentable, patented, or kept by Gensia Sicor as proprietary know-how or trade
secret, provided that the Product is manufactured by Gensia Sicor. In the event
Sonus licenses the right to develop, market and distribute the Product to a
third party who is not an Affiliate of Sonus, and such licensee desires to
transfer the manufacturing of the Product to a manufacturer other than Gensia
Sicor, and Gensia Sicor does not retain manufacturing rights pursuant to Section
12, Gensia Sicor shall negotiate in good faith to license all or any Gensia
Sicor Process Improvements to such third-party manufacturer on commercially
reasonable terms.

        11.2 SONUS IMPROVEMENTS. Any developments, inventions or discoveries
related to the manufacture of the product developed or acquired solely by Sonus
during the term of this Agreement shall be owned solely by Sonus.

        11.3 GENSIA SICOR AND SONUS IMPROVEMENTS. For any Improvements of Gensia
Sicor and Sonus jointly which relate to the manufacture of the Product, Gensia
Sicor and Sonus shall have joint rights to the Improvements, and all patents or
other intellectual property rights pertaining thereto. Joint improvements
include Improvements developed, made or conceived jointly by Gensia Sicor and
Sonus for which Sonus and Gensia Sicor would be considered joint authors under
the United States Copyright Act or joint inventors under the United States
Patent Act. Neither party may unilaterally license or assign any jointly
developed Improvements without the written consent of the other party, unless
the other party is compensated through a royalty, one-time payment or otherwise
in an amount equal to the relative value of such party's contribution to the
Improvement.

        11.4 GENSIA SICOR PRODUCT IMPROVEMENTS. Notwithstanding the provisions
of Section 11.1 herein, any developments, inventions or discoveries developed or
acquired solely by Gensia Sicor during the term of this Agreement which are
applicable to the Product ("Gensia Sicor Product Improvements") shall be owned
by Gensia Sicor, to the extent that such improvements are not covered by
existing Sonus patents, patent applications, know-how or trade secrets. Sonus
shall have a non-exclusive, royalty-free perpetual license to such Improvements
relating solely to the Product, whether such Improvements are patentable,
patented, or kept by Gensia Sicor as proprietary know-how or trade secret,
provided that such Improvements do not [ * ]. In the event a Gensia Sicor
Improvement [ * ], Gensia Sicor shall negotiate in good faith with Sonus the
terms of a license to all or any such Gensia Sicor Product Improvements

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       23
<PAGE>
12. RIGHT OF FIRST NEGOTIATION.

        In the event that Sonus licenses the right to develop, market and
distribute the Product to a third party who is not an Affiliate of Sonus, and
such licensee desires to transfer the manufacturing of the Product to a
manufacturer other than Gensia Sicor, Sonus, such licensee and Gensia Sicor
shall enter into a [ * ] period of exclusive negotiation (the "Right of First
Negotiation Period") for Gensia Sicor to retain the rights to manufacture the
Product for such third party. If the parties fail to come to an agreement during
such Right of First Negotiation Period, Sonus and such third party shall have
the right to terminate this Agreement upon six (6) months' written notice to
Gensia Sicor, and transfer the manufacturing of the Product to one or more third
parties, provided that the terms under which such third party manufactures the
Product for Sonus's licensee shall be no less favorable to Sonus' licensee than
the terms of Gensia Sicor's final offer.

13. FORCE MAJEURE.

        Any delay in the performance of any of the duties or obligations of
either party hereto (except the payment of money) shall not be considered a
breach of this Agreement and the time required for performance shall be extended
for a period equal to the period of such delay, provided that such delay has
been caused by or is the result of any acts of God; insurrections; riots;
embargoes; labor disputes, including strikes, lockouts, job actions, or
boycotts; fires; explosions; floods; shortages in transportation, or inability
to obtain necessary labor, materials, equipment, or laboratory facilities from
usual sources; or other unforeseeable causes beyond the control, and provided,
further, that the delay is not due to the fault or negligence of the party so
affected. The party so affected shall give prompt notice to the other party of
such cause and shall take whatever reasonable steps are necessary to relieve the
effect of such cause as rapidly as possible.

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

                                       24
<PAGE>

14. NOTICES.

        All notices hereunder shall be delivered personally or by registered or
certified mail, postage prepaid, to the following addresses of the respective
parties:

                   Gensia Sicor Pharmaceutical Sales, Inc.
                   19 Hughes
                   Irvine, California 92618-1902
                   Attention:     President

                   With copy to:  SICOR Inc.
                                  19 Hughes
                                  Irvine, California  92618-1902
                                  Attention:  General Counsel

                   Sonus Pharmaceuticals, Inc.
                   22026 20th Avenue S.E.
                   Bothell, Washington 98021
                   Attention:     Michael A. Martino,
                                  President and CEO

                   With copy to:  K. C. Schaaf, Esquire
                                  Stradling, Yocca, Carlson & Rauth
                                  660 Newport Center Drive, Suite 1600
                                  Newport Beach, California 92660

        Notices shall be effective upon receipt if personally delivered, or on
the third business day following the date of mailing. A party may change its
address listed above by notice to the other party.

15. APPLICABLE LAW.

        This Agreement shall be construed, interpreted and governed by the laws
of the State of California, except for choice of law rules.

                                       25
<PAGE>
16. ASSIGNMENT.

        Neither party shall assign this Agreement or any part thereof without
the prior written consent of the other party, which consent shall not be
unreasonably withheld; provided, however, (i) either party may assign this
Agreement without consent to an Affiliate of that party, or (ii) either party
may assign or sell the same without such consent in connection with the transfer
or sale of substantially its entire business to which this Agreement pertains or
in the event of its merger or consolidation with another company. Any permitted
assignee shall assume all obligations of its assignor under this Agreement. No
assignment shall relieve any party of responsibility for the performance of any
accrued obligation which such party then has hereunder.

17. ENTIRE AGREEMENT.

        This Agreement constitutes the entire agreement between the parties
concerning the subject matter hereof and supersedes all written or oral prior
agreements or understandings with respect thereto. No course of dealing or usage
of trade shall be used to modify the terms and conditions hereof.

18. SEVERABILITY.

        This Agreement is subject to the restrictions, limitations, terms and
conditions of all applicable laws, governmental regulations, approvals and
clearances. If any term or provision of this Agreement shall for any reason be
held invalid, illegal or unenforceable in any respect, such invalidity,
illegality or unenforceability shall not affect any other term or provision
hereof, and this Agreement shall be interpreted and construed as if such term or
provision, to the extent the same shall have been held to be invalid, illegal or
unenforceable, had never been contained herein.

19. WAIVER - MODIFICATION OF AGREEMENT.

        No waiver or modification of any of the terms of this Agreement shall be
valid unless in writing and signed by authorized representatives of both
parties. Failure by either party to enforce any rights under this Agreement
shall not be construed as a waiver of such rights nor shall a waiver by either
party in one or more instances be construed as constituting a continuing waiver
or as a waiver in other instances.

20. INDEPENDENT CONTRACTOR.

        Each party shall be and shall endeavor to act as the independent
contractor of the other party. Neither party shall be the legal agent of the
other party for any purpose whatsoever and therefore has no right or authority
to make or underwrite any promise, warranty or representation, to execute any
contract or otherwise to assume any obligation or responsibility in the name or
on behalf of the other party, except to the extent specifically authorized in
writing by the other party, neither of the parties hereto shall be bound by or
liable to any third persons for any act or any obligation or debt incurred by
the other towards such third party, except for the extent specifically agreed to
in writing by the party so to be bound.

                                       26
<PAGE>
21. DISPUTE RESOLUTION; ARBITRATION.

        The parties shall initially attempt in good faith to resolve any
significant controversy, claim, allegation, and breach or dispute arising out of
or relating to this Agreement (hereinafter collectively referred to a "Dispute")
through negotiations between senior executives of Sonus and Gensia Sicor. If the
Dispute is not resolved within thirty (30) days, (or such other period of time
mutually agreed upon by the parties), of notice of the dispute (the "Executive
Resolution Period"), then the parties agree to submit the Dispute to arbitration
as provided herein. Unless otherwise mutually agreed by the parties, only if the
Dispute is not resolved through negotiations as set forth herein, any party may
resort to arbitration.

        All Disputes relating in any way to this Agreement shall be resolved
exclusively through arbitration in accordance with the commercial arbitration
rules of the American Arbitration Association in then in effect. In the event
either party demands arbitration, it shall do so within thirty (30) days after
the expiration of the Executive Resolution (or any mutually agreed extension)
and shall include a request that such arbitration be held within thirty (30)
days of such demand. The arbitration hearing shall be held as soon as
practicable. The arbitration hearing shall be held in Orange County, California
and shall be before a single arbitrator selected by the parties in accordance
with the commercial arbitration rules of the American Arbitration Association
pursuant to its rules on selection of arbitrators. The arbitrator shall render a
formal, binding, non-appealable resolution and award on each issues as
expeditiously as possible, but not more then ten (10) business days after the
hearing. In any arbitration, the prevailing party shall be entitled to
reimbursement of its reasonable attorneys fees, costs and expenses incurred in
connection with the arbitration, and the parties shall use their reasonable
efforts to minimize arbitration costs.

        The parties, intending to be bound by the terms and conditions hereof,
have caused this Agreement to be signed by their duly authorized representatives
on the date first above written.

GENSIA SICOR PHARMACEUTICAL                SONUS PHARMACEUTICALS, INC.
SALES, INC.

By: /s/ Armand J. LeBlanc                  By: /s/ Michael A. Martino
    -------------------------------            ---------------------------------

Name       Armand J. LeBlanc               Name:       Michael A. Martino

Title:     President                       Title:      President and CEO

Date: June 26, 2002                        Date: June 26, 2002
      -----------------------------              -------------------------------

                                       27
<PAGE>
                                    EXHIBIT A

                        API AND EXCIPIENTS SPECIFICATIONS

1.  [ * ]

2.  [ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT B

                     PRODUCT DESCRIPTION AND SPECIFICATIONS

1. [ * ]

2. [ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT C

                             MANUFACTURING EQUIPMENT

The following estimate details the parts and equipment to be procured by Gensia
Sicor on behalf of Sonus for the manufacture of the Product.

[ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT D

                               TECHNOLOGY TRANSFER

The following estimate details those costs and services required to support the
transfer of the finished product technology of Sonus for the Product.

        [ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT E

                             PRE-COMMERCIAL SERVICES

The following estimate details those costs and services to be provided by Gensia
Sicor to support the validation and commercialization of the Product
manufacturing process.

[ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT F

                                    SCHEDULE

The following schedule details critical path items in the manufacturing scale-up
process to meet the goal of completing manufacture of the first clinical batch
of S-8184 at Gensia Sicor by end of year 2002. The project teams will together
detail and agree on a project schedule for execution of the work specified in
this agreement.

[ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT G

                           ADDITIONAL SUPPORT SERVICES

[ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT H

                              EXCESS STORAGE RATES

        [ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT I

           MANUFACTURING AND QUALITY CONTROL PROCESSES AND PROCEDURES

        [ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

<PAGE>
                                    EXHIBIT J

                         PRICING FOR COMMERCIAL SUPPLIES
        [ * ]

--------
    * Omitted pursuant to Rule 24b-2 and filed separately with the Commission.

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