Document:

Exhibit 10b

    

    

    POWER OF ATTORNEY

    

    

    We, the undersigned directors and/or officers of The Lincoln National Life Insurance Company, hereby constitute and appoint Delson R. Campbell, Scott C. Durocher,
      Kimberly A. Genovese, Daniel P. Herr, Donald E. Keller, Michelle Grindle,  Jeffrey L. Smith, Jassmin McIver-Jones, Carolyn Augur and John D. Weber,  individually, our true and lawful attorneys-in-fact, with full power to each of them to sign for us,
      in our names and in the capacities indicated below, any Registration Statements and any and all amendments to Registration Statements; including exhibits, or other documents filed on Forms N-6, N-4 or S-3 or any successors or amendments to these
      Forms, filed with the Securities and Exchange Commission, under the Securities Act of 1933 and/or Securities Act of 1940, on behalf of the Company in its own name or in the name of one of its Separate Accounts, hereby ratifying and confirming our
      signatures as they may be signed by any of our attorneys-in-fact to any such amendments to said Registration Statements as follows:

    

    

    Variable Life Insurance Separate Accounts:

    

    	
            Account

          	
            Product name

          
	
            Lincoln Life Flexible Premium Variable Life Account D (811-04592)

          	
            Variable Universal Life Leadership Series

          
	
            Lincoln Life Flexible Premium Variable Life Account F (811-05164)

          	
            American Legacy Life

            American Legacy Estate Builder

          
	
            Lincoln Life Flexible Premium Variable Life Account G (811-05585)

          	
            VUL-III

          
	
            Lincoln Life Flexible Premium Variable Life Account J (811-08410)

          	
            American Legacy Variable Life

          
	
            Lincoln Life Flexible Premium Variable Life Account K (811-08412)

          	
            Multi Fund Variable Life

          
	
            Lincoln Life Flexible Premium Variable Life Account M (811-08557)

          	
            VULdb / VULdb ES

            VULdb-II ES

            VUL-I / VULcv

            VULcv-II / VULcvII ES / VUL Flex

            VULcv-III ES

            MoneyGuard VUL

            VULone ES / VULone 2005 ES

            Momentum VULone / Momentum VULone 2005

            VULcv-IV ES

            VULdb-IV ES

            Momentum VULone 2007

            VULone 2007

            AssetEdge VUL

            AssetEdge VUL2015/AssetEdge Exec VUL 2015

            VULone2012

            VULone2014

            InReach VULone2014

            VULone2019

            AssetEdge VUL2019/AssetEdge Exec VUL 2019

            AssetEdge VUL2019-2/AssetEdge Exec VUL 2019-2

          
	
            Lincoln Life Flexible Premium Variable Life Account R (811-08579)

          	
            SVUL / SVUL-I

            SVUL-II / SVUL-II ES

            SVUL-III ES

            SVUL-IV ES / PreservationEdge SVUL

            SVULone ES

            Momentum SVULone

            SVULone 2007 ES

            Momentum SVULone 2007

            SVULone2013

            SVULone2016

            SVULone2019

          
	
            Lincoln Life Flexible Premium Variable Life Account S (811-09241)

          	
            CVUL / CVUL Series III / CVUL Series III ES

            LCV4 ES

            LCV5 ES / LCC VUL

            Lincoln Corporate Executive VUL

          
	
            Lincoln Life Flexible Premium Variable Life Account Y (811-21028)

          	
            American Legacy VULcv-III

            American Legacy VULdb-II

            American Legacy SVUL-II

            American Legacy SVUL-III

            American Legacy VULcv-IV

            American Legacy VULdb-IV

            American Legacy SVUL-IV/PreservationEdge SVUL

            American Legacy AssetEdge

          

    

    

    

    

    Variable Annuity Separate Accounts:

    

    

    	
            Account

          	
            Product name

          
	
            Lincoln National Variable Annuity Account C (811-03214)

          	
            Multi-Fund

            Multi-Fund Select

            Multi-Fund 5 Retirement Annuity

          
	
            Lincoln National Variable Annuity Account E (811-04882)

          	
            The American Legacy

          
	
            Lincoln National Variable Annuity Account H (811-05721)

          	
            American Legacy II

            American Legacy III

            American Legacy III B Class

            American Legacy III C Share

            American Legacy III Plus

            American Legacy III View

            American Legacy Design

            American Legacy Signature

            American Legacy Fusion

            American Legacy Series

            American Legacy Advisory

            American Legacy Target Date Income B Share

            American Legacy Target Date Income Advisory

            Shareholder’s Advantage

            Shareholder’s Advantage A Class

            Shareholder’s Advantage purchased on and after May 21, 2018

          
	
            Lincoln National Variable Annuity Account L (811-07645)

          	
            Group Variable Annuity

            Secured Retirement Income Version 1

            Secured Retirement Income Version 2

            Secured Retirement Income Version 3

            Secured Retirement Income Version 4

            Retirement Income Rollover Version 1

            Retirement Income Rollover Version 2

            Retirement Income Rollover Version 3

            Retirement Income Rollover Version 4

          
	
            Lincoln Life Variable Annuity Account N (811-08517)

          	
            ChoicePlus Assurance (A Share)

            ChoicePlus Assurance (A Class)

            ChoicePlus Assurance (B Share)

            ChoicePlus Assurance (B Class)

            ChoicePlus Assurance (C Share)

            ChoicePlus Assurance (L Share)

            ChoicePlus Assurance (Bonus)

            Choice Plus

            Choice Plus II

            ChoicePlus Access

            ChoicePlus II Access

            ChoicePlus Bonus

            ChoicePlus II Bonus

          
	
            Lincoln Life Variable Annuity Account N (811-08517) Continued

          	
            ChoicePlus II Advance

            ChoicePlus Design

            ChoicePlus Signature

            ChoicePlus Rollover

            ChoicePlus Fusion

            ChoicePlus Series

            ChoicePlus Prime

            ChoicePlus Advisory

            InvestmentSolutions

            InvestmentSolutions RIA

            Lincoln Investor Advantage

            Lincoln Invester Advantage 2018

            Lincoln Investor Advantage Fee-Based

            Lincoln Investor Advantage RIA

            Lincoln Investor Advantage Advisory

            Lincoln Investor Advantage RIA Class

            Lincoln Level Advantage B Share Indexed Variable Annuity

            Lincoln Level Advantage Advisory Indexed Variable Annuity

            Lincoln Level Advantage B Class Indexed Variable Annuity

            Lincoln Level Advantage Advisory Class Indexed Variable Annuity

            Lincoln Level Advantage Fee-Based Indexed Variable Annuity

            Lincoln Level Advantage Select B-Share Indexed Variable Annuity

            Core Income

          
	
            Lincoln Life Variable Annuity Account Q (811-08569)

          	
            Multi-Fund Group

          
	
            Lincoln Life S-3 Filing

          	
            Lincoln Level Advantage B Share Indexed Variable Annuity

            Lincoln Level Advantage Advisory Indexed Variable Annuity

            Lincoln Level Advantage B Class Indexed Variable Annuity

            Lincoln Level Advantage Advisory Class Indexed Variable Annuity

            Lincoln Level Advantage Fee-Based Indexed Variable Annuity

            Lincoln Level Advantage Select B Share Indexed Variable Annuity

          

    

    

    

    

    Except as otherwise specifically provided herein, the power-of-attorney granted herein shall not in any manner revoke in whole or in part any power-of-attorney that each person whose signature appears below has
      previously executed.  This power-of-attorney shall not be revoked by any subsequent power-of-attorney each person whose signature appears below may execute, unless such subsequent power specifically refers to this power-of-attorney or specifically
      states that the instrument is intended to revoke all prior general powers-of-attorney or all prior powers-of-attorney.

    

    

    This Power-of-Attorney may be executed in separate counterparts each of which when executed and delivered shall be an original; but all such counterparts shall together constitute one and the same
      instrument.  Each counterpart may consist of a number of copies, each signed by less than all, but together signed by all, of the undersigned.

    

    

    

    

    Signature                                                                                    Title

    

    

    

    

    /s/Dennis R. Glass

    
      
        	______________________________	
                President, Chairman and Director

              

      

    

    Dennis R. Glass

    

    

    

    

    /s/Ellen Cooper

    
      
        	______________________________	
                Executive Vice President, Chief Investment Officer

              

      

    

    Ellen Cooper                                                                                    and Director

    
      
        

    

    

    

    /s/Randal J. Freitag

    
      
        	______________________________	
                Executive Vice President; Chief Financial Officer and Director

              

      

    

    Randal J. Freitag

    

    

    

    

    /s/Leon E. Roday

    
      
        	______________________________	
                Executive Vice President, General Counsel and Director

              

      

    

    Leon E. Roday

    

    

    

    

    /s/Wilford H. Fuller

    
      
        	______________________________	
                Executive Vice President and Director

              

      

    

    Wilford H. Fuller

    

    

    

    

    /s/Keith J. Ryan

    ______________________________                                                                                                  Vice
      President and Director

    Keith J. Ryan

    

    

    

    

    

    

    We, Delson R. Campbell, Scott C. Durocher, Kimberly A. Genovese, Daniel P. Herr, Donald E. Keller, Michelle Grindle, Jeffrey L. Smith, Jassmin McIver-Jones, Carolyn Augur and John D. Weber, have
      read the foregoing Power of Attorney.  We are the person(s) identified therein as agent(s) for the principal named therein.  We acknowledge our legal responsibilities.

    

    

    /s/Delson R. Campbell                                                                                                                              /s/Scott
      C. Durocher

    ____________________________________                                                                                                                              _____________________________________

    Delson R. Campbell                                                                                                                              Scott
      C. Durocher

    

    

    /s/Kimberly A. Genovese                                                                                                                /s/Daniel
      P. Herr

    ____________________________________                                                                                                                              _____________________________________

    Kimberly A. Genovese                                                                                                                              Daniel
      P. Herr

    

    

    /s/Donal E. Keller                                                                                                                /s/Michelle
      Grindle

    ____________________________________                                                                                                                              _____________________________________

    Donald E. Keller                                                                                                                Michelle
      Grindle

    

    

    /s/Jeffrey L. Smith                                                                                                                /s/John
      D. Weber

    _____________________________________                                                                                                                              _____________________________________

    Jeffrey L. Smith                                                                                                                              John
      D. Weber

    

    

    /s/Jassmin McIver-Jones                                                                                                                /s/Carolyn
      Augur

    _____________________________________                                                                                                                              _____________________________________

    Jassmin McIver-Jones                                                                                                                              Carolyn
      Augur

    

    

    

    

    

    

    

    

    

    

    Version dated: October 2019Exhibit 10.1

 

SECURITIES PURCHASE AGREEMENT

 

This Securities Purchase
Agreement (this “Agreement”) is dated as of December __, 2019, between Wize Pharma, Inc., a Delaware corporation
(the “Company”), and the purchasers set forth on the signature pages affixed hereto (each, a “Purchaser”
and, collectively, the “Purchasers”).

 

WHEREAS, subject
to the terms and conditions set forth in this Agreement and pursuant to an exemption from the registration requirements of Section
5 of the Securities Act contained in Section 4(a)(2) thereof, the Company desires to issue and sell to the Purchasers, and Purchasers
severally and not jointly desire to purchase from the Company, securities of the Company as more fully described in this Agreement.

 

NOW, THEREFORE,
IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration the receipt
and adequacy of which are hereby acknowledged, the Company and the Purchasers agree as follows:

 

ARTICLE I.

DEFINITIONS

 

1.1
Definitions. In addition to the terms defined elsewhere in this Agreement the following terms have the meanings set forth in
this Section 1.1:

 

“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or
any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to
close.

 

“Closing”
means the closing of the purchase and sale of the Shares pursuant to Section 2.1 hereof.

 

“Closing Date”
means the Trading Day on which all of the Transaction Documents have been executed and delivered by the applicable parties thereto,
and all conditions precedent to (i) the Purchasers’ obligations to pay the Purchase Price and (ii) the Company’s obligations
to deliver the Shares and Warrants, in each case, have been satisfied or waived, subject to the provisions of Section 2.1.

 

“Commission”
means the United States Securities and Exchange Commission.

 

“Common Stock”
means the common stock of the Company, par value $0.001 per share, and any other class of securities into which such securities
may hereafter be reclassified or changed.

 

“Exchange
Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 

“Liens”
means a lien, charge, pledge, security interest, encumbrance, right of first refusal, preemptive right or other restriction.

 

“Material Adverse Effect”
means: (i) a material adverse effect on the legality, validity or enforceability of any Transaction Document, (ii) a material adverse
effect on the results of operations, assets, business, prospects or condition (financial or otherwise) of the Company and the Subsidiaries,
taken as a whole, in the long term or (iii) a material adverse effect on the Company’s ability to perform in any material
respect on a timely basis its obligations under any Transaction Document; provided, however, that none of the following shall be
taken into account in determining whether there has been, or could be, a Material Adverse Effect: (a) any adverse change, event,
development, or effect (whether short-term or long-term) arising from or relating to (1) general business or economic conditions,
including such conditions related to the business of the Company and its Subsidiaries, (2) any national or international political
or social conditions, (3) financial, banking, or securities markets (including any disruption thereof and any decline in the price
of any security or any market index), (4) changes in GAAP, (5) changes in laws, rules, regulations, orders, or other binding directives
issued by any governmental entity, or (6) the taking of any action contemplated by any Transaction Document, (b) any failure to
meet a forecast (whether internal or published) of revenue, earnings, cash flow, or other data for any period or any change in
such a forecast, and (c) any existing event, occurrence, or circumstance with respect to which any Purchaser has knowledge as of
the date hereof.

 

     

     

    

 

“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.

 

“SEC Reports”
shall have the meaning ascribed to such term in Section 3.2(d) hereof.

 

“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 

“Shares”
has the meaning ascribed to such term in Section 2.1 hereof.

 

“Subsidiary”
means with respect to any entity at any date, any direct or indirect corporation, limited or general partnership, limited liability
company, trust, estate, association, joint venture or other business entity of which (A) more than 30% of (i) the outstanding
capital stock having (in the absence of contingencies) ordinary voting power to elect a majority of the board of directors or other
managing body of such entity, (ii) in the case of a partnership or limited liability company, the interest in the capital
or profits of such partnership or limited liability company or (iii) in the case of a trust, estate, association, joint venture
or other entity, the beneficial interest in such trust, estate, association or other entity business is, at the time of determination,
owned or controlled directly or indirectly through one or more intermediaries, by such entity, or (B) is under the actual control
of the Company.

 

“Trading Day”
means a day on which the principal Trading Market is open for trading.

 

“Trading Market”
means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on the date in question:
the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange
or any tier of the OTC Markets operated by the OTC Markets Group, Inc. (or any successors to any of the foregoing).

 

“Transaction
Documents” means this Agreement, the Warrant and any other documents executed in connection with the transaction contemplated
hereunder.

 

“Transfer
Agent” means Issuer Direct Corporation, the current transfer agent of the Company, and any successor transfer agent of
the Company.

 

“ Warrant”
has the meaning ascribed to such term in Section 2.1 hereof.

 

“Warrant Shares”
means the shares of Common Stock issuable upon the exercise of the Warrants.

 

ARTICLE II.

PURCHASE AND SALE

 

2.1 Closing.
On the Closing Date, upon the terms and subject to the conditions set forth herein, substantially concurrent with the execution
and delivery of this Agreement by the parties hereto, the Company shall sell, and the Purchasers shall, severally and not jointly,
purchase up to __________ shares of Common Stock (the “Shares”) in the respective amounts set forth on the signature
pages attached hereto at $0.27 per share for an aggregate purchase price of up to $_________ (the “Purchase Price”)
and the Company shall also issue to each Purchaser a Warrant (the “Warrant”), substantially in the form of Exhibit
“A” attached hereto, to purchase two shares of Common Stock for each share of Common Stock purchased by such Purchaser
pursuant to this Agreement. At or prior to the Closing, the Company and the Purchaser shall deliver the other items set forth in
Section 2.2, hereof. Upon satisfaction of the covenants and conditions set forth in Sections 2.2 and 2.3, hereof, the Closing shall
occur at the offices of the Company or such other location, including through electronic transmission, as the parties shall mutually
agree.

 

    - 2 -

     

    

 

2.2 Deliveries.

 

		(a)	On or prior to the Closing Date, the Company shall deliver
to the Purchasers this Agreement duly executed by the Company. The Company shall deliver or cause to be delivered to the Purchaser
the Shares and the Warrants purchased by such Purchasers in the amounts set forth on the signature page to this Agreement to the
address set forth on the signature page to this Agreement within 5 Business Days of the Closing Date.

 

		(b)	On or prior to the Closing Date, each Purchaser shall each deliver or cause to be delivered to
the Company this Agreement duly executed by such Purchaser and the Purchase Price for the aggregate number of Shares to be purchased
by such Purchaser as set forth on the signature page to this Agreement by wire of immediately available funds.

 

2.3 Closing
Conditions.

 

(a) The
obligations of the Company hereunder in connection with the Closing are subject to the following conditions being met:

 

		(i)	the accuracy in all material respects on the Closing Date of the representations and warranties
of the Purchaser contained herein (unless as of a specific date therein in which case they shall be accurate as of such date)

 

		(ii)	all obligations, covenants and agreements of the Purchaser required to be performed at or prior
to the Closing Date shall have been performed; and

 

		(iii)	the delivery by the Purchaser of the item set forth in Section 2.2(b) hereof.

 

(b) The
obligation of the Purchaser hereunder in connection with the Closing are subject to the following conditions being met:

 

		(i)	the accuracy in all material respects when made and on the Closing Date of the representations
and warranties of the Company contained herein (unless as of a specific date therein);

 

		(ii)	all obligations, covenants and agreements of the Company required to be performed at or prior to
the Closing Date shall have been performed;

 

		(iii)	from the date hereof to the Closing Date, trading in the Common Stock shall not have been suspended
by the Commission or the Company’s principal Trading Market, and, at any time prior to the Closing Date, trading in securities
generally as reported by Bloomberg L.P. shall not have been suspended or limited, or minimum prices shall not have been established
on securities whose trades are reported by such service, or on any Trading Market; and

 

		(iv)	the delivery by the Company of the items set forth in Section 2.2(a) hereof.

 

ARTICLE III

REPRESENTATIONS AND WARRANTIES

 

3.1 Representations
and Warranties of the Company. The Company hereby makes the following representations and warranties to the Purchasers:

 

(a) The
Company is a corporation, validly existing and in good standing under the laws of Delaware.

 

    - 3 -

     

    

 

(b) The
Company has the requisite corporate power and authority to enter into and to consummate the transactions contemplated by this Agreement
and otherwise to carry out its obligations hereunder. The execution and delivery of this Agreement by the Company and the consummation
by it of the transactions contemplated hereby and thereby have been duly authorized by all necessary action on the part of the
Company.

 

(c) The
execution, delivery and performance by the Company of this Agreement, the issuance and sale of the Shares and Warrant and the consummation
by it of the transactions contemplated hereby party do not and will not conflict with or violate any provision of the Company’s
articles of incorporation or other organizational or charter documents. The Shares, upon issuance in accordance with this Agreement,
and the Warrant Shares upon exercise in accordance with the Warrant will be duly issued, fully paid, and nonassessable.

 

(d) The Company has
filed all reports, schedules, forms, statements and other documents required to be filed by the Company under the Securities Act
and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the date hereof (or such
shorter period as the Company was required by law or regulation to file such material) (the foregoing filed materials, including
the exhibits thereto and documents incorporated by reference therein, being collectively referred to herein as the “SEC Reports”).
As of their respective dates, the SEC Reports complied in all material respects with the requirements of the Securities Act and
the Exchange Act, as applicable, and none of the SEC Reports, when filed, contained any untrue statement of a material fact or
omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light
of the circumstances under which they were made, not misleading. The financial statements of the Company included in the SEC Reports
comply in all material respects with applicable accounting requirements and the rules and regulations of the SEC with respect thereto
as in effect at the time of filing.

 

(e) Since the date
of the latest audited financial statements included within the SEC Reports, there has been no event, occurrence or development
that has had or that would reasonably be expected to result in a Material Adverse Effect,.

 

(f) The Shares are duly
authorized and, when issued and paid for in accordance with the applicable Transaction Documents, will be duly and validly issued,
fully paid and nonassessable, free and clear of all Liens imposed by the Company. The Warrant Shares, when issued upon exercise
of the Warrant, will be validly issued, fully paid and nonassessable, free and clear of all Liens imposed by the Company.

 

(g)
There is no action, suit, inquiry, notice of violation, proceeding or investigation pending or, to the knowledge of the Company,
threatened against or affecting the Company, any Subsidiary or any of their respective properties before or by any court, arbitrator,
governmental or administrative agency or regulatory authority (federal, state, county, local or foreign) (collectively, an “Action”)
which (i) adversely affects or challenges the legality, validity or enforceability of any of the Transaction Documents or the issuance
of the Securities or (ii) could, if there were an unfavorable decision, have or reasonably be expected to result in a Material
Adverse Effect.

 

(h)
Based on the consolidated financial condition of the Company as of the date of this Agreemente, after giving effect to the receipt
by the Company of the proceeds from the sale of the Securities hereunder, (i) the fair saleable value of the Company’s assets
exceeds the amount that will be required to be paid on or in respect of the Company’s existing debts and other liabilities
(including known contingent liabilities) as they mature, (ii) the Company’s assets do not constitute unreasonably small capital
to carry on its business as now conducted and as proposed to be conducted including its capital needs taking into account the particular
capital requirements of the business conducted by the Company, consolidated and projected capital requirements and capital availability
thereof, and (iii) the current cash flow of the Company, together with the proceeds the Company would receive, were it to liquidate
all of its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in
respect of its liabilities when such amounts are required to be paid. As of the date hereof, the Company has no intention to file
for reorganization or liquidation under the bankruptcy.

 

    - 4 -

     

    

 

3.2 Representations
and Warranties of the Purchasers. Each Purchaser severally and not jointly hereby represents and warrants as of the date hereof
and as of the Closing Date to the Company as follows (unless as of a specific date therein, in which case they shall be accurate
as of such date):

 

(a) Authority.
Each Transaction Document to which Purchaser is a party has been duly executed by the Purchaser, and when delivered by the Purchaser
in accordance with the terms hereof, will constitute the valid and legally binding obligation of the Purchaser, enforceable against
it in accordance with its terms, except: (i) as limited by general equitable principles and applicable bankruptcy, insolvency,
reorganization, moratorium and other laws of general application affecting enforcement of creditors’ rights generally, (ii)
as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies and (iii)
insofar as indemnification and contribution provisions may be limited by applicable law.

 

(b) Understandings
or Arrangements. The Purchaser is acquiring the Shares, Warrant and Warrant Shares as principal for its own account and has
no direct or indirect arrangement or understandings with any other persons to distribute or regarding the distribution of such
Shares, Warrantand Warrant Shares. The Purchaser is acquiring the Shares hereunder in the ordinary course of its business.

 

(c) Purchaser
Status. At the time the Purchaser was offered the Shares, it was, and as of the date hereof it is and on each date on which
it exercise the Warrant it will be an “accredited investor” as defined in Rule 501(a) under the Securities Act.

 

(d) Experience
of the Purchaser. The Purchaser, either alone or together with its representatives, has such knowledge, sophistication and
experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment
in the Shares and the Warrants, and has so evaluated the merits and risks of such investment. The Purchaser understands that an
investment in the Shares, Warrant and Warrant Shares involve a high degree of risk, including the risks set forth in the SEC Reports
since January 1, 2018. The Purchaser is able to bear the economic risk of an investment in the Shares, Warrant and Warrant Shares
and, at the present time, is able to afford a complete loss of such investment.

 

(e) Access
to Information. The Purchaser acknowledges that it has had the opportunity to review the Transaction Documents (including all
exhibits and schedules thereto) and the SEC Reports and has been afforded, (i) the opportunity to ask such questions as it has
deemed necessary of, and to receive answers from, representatives of the Company concerning the terms and conditions of the offering
of the Shares, Warrant and Warrant Shares and the merits and risks of investing in the Shares, Warrant and Warrant Shares; (ii)
access to information about the Company and its financial condition, results of operations, business, properties, management and
prospects sufficient to enable it to evaluate its investment; and (iii) the opportunity to obtain such additional information that
the Company possesses or can acquire without unreasonable effort or expense that is necessary to make an informed investment decision
with respect to the investment. Each Purchaser acknowledges that such Purchaser is aware that as a result of certain other transactions
consummated by the Company as well as the transactions contemplated by this Agreement, the exercise price of certain outstanding
warrants may be reduced pursuant to the terms of such warrants.

 

(f)  Restricted
Securities. The Purchaser understands that the Shares, Warrant and Warrant Shares are restricted securities within the meaning
of the Securities Act, have not been registered under the Securities Act or any state securities laws and may not be transferred
or sold except pursuant to an effective registration statement or an available exemption therefrom. The Purchaser agrees to the
imprinting, so long as is required by this Section 3.2 (f), of a legend on any of the Shares, Warrant and Warrant Shares in the
following form:

 

THESE SECURITIES
HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON
AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY,
MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE
EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH
APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF
WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. THESE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT
WITH A REGISTERED BROKER-DEALER OR OTHER LOAN WITH A FINANCIAL INSTITUTION THAT IS AN “ACCREDITED INVESTOR”
AS DEFINED IN RULE 501(a) UNDER THE SECURITIES ACT.

 

    - 5 -

     

    

 

ARTICLE IV.

REGISTRATION RIGHTS 

 

4.1 Demand
Registration Rights. At any time that any Purchaser owns any Shares, Warrants or Warrant Shares, any such Purchaser may make
written requests to the Company to require the Company to register, udner and in accordance with the provisions of the Securities
Act, any or all of such Purchaser’s Shares and Warrant Shares (a “Demand Registration”).

 

4.2 Registration
Rights Agreement. The Company shall use its commercially reasonable best efforts to prepare and file a registration statement on
an appropriate form with respect to any Demand Registration (the “Demand Registration Statement”) as promptly
as reasonably practicable after receiving such Demand Notice, and the Company shall use its commercially reasonable best efforts
to cause the Demand Registration Statement to become effective as promptly as reasonably practicable after the filing thereof.

 

4.3 Rule
415 Limitation. Notwithstanding anything herein to the contrary, the Company shall not be required to register any Shares or
Warrant Shares as a result of a limitation on the maximum number of shares of Common Stock permitted to be registered by the staff
of the Commission pursuant to Rule 415 promulgated under the Securities Act or any successor rule providing for offering securities
on a continuous or delayed basis.

 

ARTICLE V.

MISCELLANEOUS

 

5.1 Expenses.
The Company shall pay all Transfer Agent fees (including, without limitation, any fees required for same-day processing of any
instruction letter delivered by the Company), stamp taxes and other taxes and duties levied in connection with the delivery of
the Shares, Warrant and Warrant Shares to the Purchaser other than income and capital gains taxes of the Purchaser that may be
incurred in connection with the transactions contemplated hereby.

 

5.2 Entire
Agreement. The Transaction Documents contain the entire understanding of the parties with respect to the subject matter hereof
and thereof and supersede all prior agreements and understandings, oral or written, with respect to such matters, which the parties
acknowledge have been merged into such documents, exhibits and schedules.

 

5.3 Notices.
Any and all notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and
shall be deemed given and effective on the earliest of: (a) the date of transmission, if such notice or communication is delivered
via facsimile or e-mail at the facsimile number or e-mail address set forth on the signature pages attached hereto at or prior
to 5:30 p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of transmission, if such notice or
communication is delivered via facsimile or e-mail at the facsimile number or e-mail address set forth on the signature pages attached
hereto on a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (c) the second (2nd)
Trading Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service or (d) upon actual receipt
by the party to whom such notice is required to be given. The address for such notices and communications shall be as set forth
on the signature pages attached hereto.

 

5.4 Amendments;
Waivers. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed
by the Company and the Purchaser. No waiver of any default with respect to any provision, condition or requirement of this Agreement
shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision,
condition or requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any manner impair
the exercise of any such right.

 

    - 6 -

     

    

 

5.5 Headings.
The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect
any of the provisions hereof.

 

5.6 Successors
and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted
assigns. Neither the Purchaser nor the Company may assign this Agreement or any rights or obligations hereunder without the prior
written consent of the other party (other than by operation of law).

 

5.7 Governing
Law. All questions concerning the construction, validity, enforcement and interpretation of the Transaction Documents shall
be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the
principles of conflicts of law thereof. Each party agrees that all legal proceedings concerning the interpretations, enforcement
and defense of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a party
hereto or its respective affiliates, directors, officers, shareholders, partners, members, employees or agents) shall be commenced
exclusively in the state and federal courts sitting in the City of New York. Each party hereby irrevocably submits to the exclusive
jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan for the adjudication of any
dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect
to the enforcement of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any suit, action
or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding
is improper or is an inconvenient venue for such proceeding. Each party hereby irrevocably waives personal service of process and
consents to process being served in any such suit, action or proceeding by mailing a copy thereof via registered or certified mail
or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under this Agreement
and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein
shall be deemed to limit in any way any right to serve process in any other manner permitted by law. If either party shall commence
an action or proceeding to enforce any provisions of the Transaction Documents, then the prevailing party in such action, suit
or proceeding shall be reimbursed by the other party for its reasonable attorneys’ fees and other costs and expenses incurred
with the investigation, preparation and prosecution of such action or proceeding.

 

5.8 Survival.
The representations and warranties contained herein shall survive the Closing and the delivery of the Shares.

 

5.9 Execution.
This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same
agreement and shall become effective when counterparts have been signed by each party and delivered to each other party, it being
understood that the parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission
or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of the
party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf”
signature page were an original thereof.

 

5.10 Severability.
If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal,
void or unenforceable, the remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full
force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially
reasonable efforts to find and employ an alternative means to achieve the same or substantially the same result as that contemplated
by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that
they would have executed the remaining terms, provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.

 

5.11 Remedies.
In addition to being entitled to exercise all rights provided herein or granted by law, including recovery of damages, the Purchaser
and the Company will be entitled to specific performance under the Transaction Documents. The parties agree that monetary damages
may not be adequate compensation for any loss incurred by reason of any breach of obligations contained in the Transaction Documents
and hereby agree to waive and not to assert in any action for specific performance of any such obligation the defense that a remedy
at law would be adequate.

 

    - 7 -

     

    

 

5.12 Saturdays,
Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of any right required or
granted herein shall not be a Business Day, then such action may be taken or such right may be exercised on the next succeeding
Business Day.

 

5.13 Construction.
The parties agree that each of them and/or their respective counsel have reviewed and had an opportunity to revise the Transaction
Documents and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting
party shall not be employed in the interpretation of the Transaction Documents or any amendments thereto. In addition, each and
every reference to share prices and shares of Common Stock in any Transaction Document shall be subject to adjustment for reverse
and forward stock splits, stock dividends, stock combinations and other similar transactions of the Common Stock that occur after
the date of this Agreement.

 

5.14 No
Third Party Beneficiaries. This Agreement is intended for the benefit of the parties hereto and their respective successors
and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person, except as otherwise
set forth in Sections 5.6 and 5.17 hereof.

 

5.15 Replacement
of Securities. If any certificate or instrument evidencing any Shares, Warrant or Warrant Shares is mutilated, lost, stolen
or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof (in
the case of mutilation), or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of evidence
reasonably satisfactory to the Company of such loss, theft or destruction. The applicant for a new certificate or instrument under
such circumstances shall also pay any reasonable third-party costs (including customary indemnity) associated with the issuance
of such replacement Shares, Warrant or Warrant Shares, as the case may be.

 

5.16 Independent
Nature of Purchasers. The obligations of each Purchaser under this Agreement or other transaction document are several and
not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance of
the obligations of any other Purchaser under this Agreement or any other transaction document. Each Purchaser shall be responsible
only for its own representations, warranties, agreements and covenants hereunder. The decision of each Purchaser to purchase the
Shares and Warrants pursuant to this Agreement has been made by such Purchaser independently of any other Purchaser and independently
of any information, materials, statements or opinions as to the business, affairs, operations, assets, properties, liabilities,
results of operations, condition (financial or otherwise) or prospects of the Company which may have been made or given by any
other Purchaser or by any agent or employee of any other Purchaser, and no Purchaser or any of its agents or employees shall have
any liability to any other Purchaser (or any other person) relating to or arising from any such information, materials, statements
or opinions. Nothing contained herein or in any other transaction document, and no action taken by any Purchaser pursuant hereto
or thereto, shall be deemed to constitute the Purchasers as a partnership, an association, a joint venture or any other kind of
entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations
or the transactions contemplated by this Agreement. Except as otherwise provided in this Agreement or any other transaction document,
each Purchaser shall be entitled to independently protect and enforce its rights arising out of this Agreement or out of the other
transaction documents, and it shall not be necessary for any other Purchaser to be joined as an additional party in any proceeding
for such purpose. Each Purchaser has been represented by its own separate legal counsel in connection with the transactions contemplated
hereby.

 

5.17 Indemnification.
In consideration of each Purchaser’s execution and delivery of the Transaction Documents and acquiring the Shares, Warrants
and Warrant Shares thereunder and in addition to all of the Company’s other obligations under the Transaction Documents,
the Company shall defend, protect, indemnify and hold harmless each Purchaser and each other holder of the Shares, Warrants and
Warrant Shares and all of their stockholders, partners, members, officers, directors, employees and direct or indirect investors
and any of the foregoing Persons’ agents or other representatives (including, without limitation, those retained in connection
with the transactions contemplated by this Agreement) (collectively, the “Indemnitees”),
as incurred, from and against any and all actions, causes of action, suits, claims, losses, costs, penalties, fees, liabilities
and damages, and expenses in connection therewith (irrespective of whether any such Indemnitee is a party to the action for which
indemnification hereunder is sought), and including reasonable attorneys’ fees and disbursements (the “Indemnified
Liabilities”), incurred by any Indemnitee (unless such action is based solely upon
any conduct by such Indemnitee which is finally judicially determined to constitute fraud, gross negligence, willful misconduct
or malfeasance), as a result of, or arising out of, or relating to (a) any misrepresentation or breach of any representation or
warranty made by the Company in the Transaction Documents or any other certificate, instrument or document contemplated hereby
or thereby, (b) any breach of any covenant, agreement or obligation of the Company contained in the Transaction Documents or any
other certificate, instrument or document contemplated hereby or thereby or (c) any cause of action, suit or claim brought or made
against such Indemnitee by a third party (including for these purposes a derivative action brought on behalf of the Company) and
arising out of or resulting from (i) the execution, delivery, performance or enforcement of the Transaction Documents or any other
certificate, instrument or document contemplated hereby or thereby, or (ii) the status of such Purchaser or holder of the Shares,
Warrants and Warrant Shares as an investor in the Company pursuant to the transactions contemplated by the Transaction Documents.
To the extent that the foregoing undertaking by the Company may be unenforceable for any reason, the Company shall make the maximum
contribution to the payment and satisfaction of each of the Indemnified Liabilities that is permissible under applicable law. 

 

[Signature Pages Follow]

 

    - 8 -

     

    

 

IN WITNESS WHEREOF,
the undersigned has duly executed this Securities Purchase Agreement as of the date first indicated above.

 

	WIZE PHARMA, INC. 	 
	 	 	 
	 	 	 
	By:	      	 
	Name: Noam Danenberg	 
	Title: Chief Executive Officer	 
	 	 	 
	Address for Notice:	 
	 	 	 
	24 Hanagar Street, 	 
	Hod Hasharon, Israel	 
	4527708	 
	Email:	 	 

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK

SIGNATURE PAGE FOR PURCHASER FOLLOWS]

 

    - 9 -

     

    

 

[PURCHASER SIGNATURE PAGE TO SECURITIES
PURCHASE AGREEMENT]

 

IN WITNESS WHEREOF, the undersigned
has duly executed this Securities Purchase Agreement as of the date first indicated above.

 

	 	 
	(Name)	
	 	 
	 	 
	Number of Shares of	 
	Common stock being purchased	 

 

Warrant to Purchase ________ shares of
the Company’s common stock

 

$_________________________

Aggregate Purchase Price

 

Address for Notice:

 

Address for delivery of Shares and Invesment
Right (if different from address for notice):

 

Social Security #:

 

    - 10 -

     

    

 

[PURCHASER SIGNATURE PAGE TO SECURITIES
PURCHASE AGREEMENT]

 

IN WITNESS WHEREOF, the undersigned
has duly executed this Securities Purchase Agreement as of the date first indicated above.

 

	 	 
	 	(Name)
	 	 
	 	 
	Number of Shares of	 
	Common stock being purchased	 

 

Warrant to Purchase ________ shares of
the Company’s common stock

 

$_________________________

Aggregate Purchase Price

 

Address for Notice:

 

Address for delivery of Shares and Warrant
(if different from address for notice):

 

Social Security #:

 

 

- 11 -

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