Document:

Prepared by R.R. Donnelley Financial -- EX-10.16(d)

 Exhibit 10.16(d) 

 

CONFIDENTIAL 

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential
treatment has been requested with respect to the omitted portions. 

 AMENDMENT #3 TO TASK ORDER #13 

COHERUS Project Number: CHS0214-02 

MEDPACE Project Number: ETA302 

This Amendment #3 (“Amendment #3”) to Task Order #13 effective as of 18 October 2013 (“Task Order”), is by and
between Coherus Bioscience, Inc., a Delaware corporation with its principal place of business at 201 Redwood Shores Parkway, Suite 200 Redwood City, CA 94065 (“Sponsor”), and Medpace, Inc., with its principal place of business at 5375
Medpace Way, Cincinnati, Ohio 45227 (“Medpace”). This Amendment #3 shall be effective 30 May 2014. 
 WITNESSETH: 

WHEREAS, the Parties have entered into Task Order pursuant and subject to the terms of the Master Service Agreement dated 23 January
2012, (the “Agreement”); and 
 WHEREAS, the Parties desire to amend Task Order in connection with a Phase 3, A Double-Blind,
Randomized, Parallel-Group, Active-Control Study to Compare the Efficacy and Safety of CHS-0214 DP Versus Enbrel® in Subjects with Rheumatoid Arthritis and Inadequate Response to Treatment
with Methotrexate to increase the MRL and [***] fees included in the Budget. 
 NOW, THEREFORE, in consideration of the mutual covenants
contained herein, the Parties hereby agree as follows to the revised Scope of Work: 
  

	 	1.	Appendix F: MRL and [***] Services and Budget attached to Task Order #13 is hereby amended by Appendix F attached to this Amendment #3. 

 

	 	2.	The MRL and [***] Fees line item included under the Pass-through Expenses category in Appendix C: Services and Budget is hereby increased from [***] to [***]. (“Increase”). 

 

	 	3.	As a result of the Increase in the Budget, Appendix D: Payment Schedule, attached to the Task Order is hereby amended to include the following: 

A total of [***] is due upon execution of Amendment #3. The remainder of the Increase will be paid in accordance with the terms of Appendix D:
Payment Schedule, attached to the Task Order. 
 The total amount payable by Sponsor to Medpace under this Amendment #3 for Medpace Direct Fees,
Pass-through Expenses, and Pre-funded Expenses shall not exceed the amount of [***] without prior written consent of both parties. The total value of Task Order and all subsequent amendments is now [***]. 

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 1

									
	 	  	Direct Fees	  	Pass Through Costs	  	Pre-funded Expenses	  	TOTAL
	 Task Order #13
	  	[***]	  	[***]	  	[***]	  	[***]
	 Amendment #1
	  	[***]	  	[***]	  	[***]	  	[***]
	 Amendment #2
	  	[***]	  	[***]	  	[***]	  	[***]
	 Amendment #3
	  	[***]	  	[***]	  	[***]	  	[***]
	 TOTAL
	  	[***]	  	[***]	  	[***]	  	[***]

 All other provisions of the Agreement and Task Order shall remain unchanged and in effect. 

IN WITNESS WHEREOF, the Parties have hereunto signed this Amendment #3 to Task Order in their official capacities which shall be effective on the day and year
listed above. 
  

			
	MEDPACE, INC.
		
	Signature:	 	/s/ John Wynne
		
	By:	 	John Wynne
		 	    (Print Name)
		
	Title:	 	Vice President
		 	Commercial Operations

  

			
	COHERUS BIOSCIENCES, INC.
		
	Signature:	 	/s/ Dennis M. Lanfear
		
	By:	 	Dennis M. Lanfear
		 	    (Print Name)
		
	Title:	 	President & CEO 5/30/14

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 2

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
	 Sponsor: Coherus Biosciences
 Protocol:
CHS-0214-02
	  	 30-May-14

  

					
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 Total Medpace Reference Laboratories Fees
	  	 	[***]	  

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 3

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 Medpace Reference Laboratories Fee Estimate 

 

																																							
	Sponsor: Coherus Biosciences	  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
	Protocol: CHS-0214-02	  		  		  		  		  		  		  	[***]	 		  		  		  		  		  		  		  	
																				
		 		 		  		  		  		  		  		  		  		  		  	[***]	 		  		  		  		  		  		  		  	
	 	 	 	 	 	  	Unit Cost	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	Total
Number
of Units	  	Cost	  	Subtotal
	 Laboratory Tests
	  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	[***]
		 		 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  	[***]	  	[***]	  		  		  		  	[***]	  		  	[***]	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  	[***]	  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
	 Laboratory Support Services
	  		  		  		  		  		 		  		  		  		  		  		  		  	[***]
	 [***]
	 		 		  		  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
		 	[***]	 		  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 	[***]	 		  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
	 [***]
	 		 		  		  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
		 		 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
	 [***]
	 		 		  		  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
		 		 	[***]	  	[***]	  		  	[***]	  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  	[***]	  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  	[***]	  		  		  		  	[***]	  		  	[***]	 		  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
		 		 	[***]	  	[***]	  		  		  		  		  		  		  		  		 		  		  		  		  		  		  		  	
	Total Medpace Reference Laboratory Fees	  		  		  		  		 		  		  		  		  		  		  		  	[***]

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 4

	
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 Medpace Reference Laboratories Fee Estimate 

 

																																					
	Sponsor: Coherus Biosciences	 		 		 		 		 		 		 		 		 		 		 		 		 		 	
	Protocol: CHS-0214-02	 		 		 		 		 		 	[***]	 		 		 		 		 		 		 		 	
																			
		  		  		 		 		 		 		 		 		 		 	[***]	 		 		 		 		 		 		 		 	
	 	  	 	  	Unit Cost	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	Total
Number
of Units	 	Cost	 	Subtotal
	Laboratory Tests	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]
		  	[***]	  	[***]	 	[***]	 	[***]	 		 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 		 	[***]	 	[***]	 	[***]	 	
		  	[***]	  	[***]	 	[***]	 	[***]	 		 	[***]	 		 	[***]	 		 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	
		  	[***]	  	[***]	 	[***]	 	[***]	 		 	[***]	 		 	[***]	 		 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	
		  	[***]	  		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	
		  	[***]	  	[***]	 	[***]	 	[***]	 		 		 		 	[***]	 		 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	
		  	[***]	  	[***]	 	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
	Laboratory Support Services	 		 		 		 		 		 		 		 		 		 		 		 	[***]
	 [***]
	  		  		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
	 [***]
	  		  		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	
		  	[***]	  	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
	 [***]
	  		  		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	
		  	[***]	  	[***]	 		 	[***]	 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 	[***]	 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 	[***]	 		 		 		 	[***]	 		 	[***]	 		 	[***]	 	[***]	 	[***]	 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 	[***]	 		 	[***]	 	[***]	 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	
		  	[***]	  	[***]	 		 		 		 		 		 		 		 		 		 		 		 		 		 		 		 	
	 Total Medpace Reference Laboratory Fees
	 		 		 		 		 		 		 		 		 		 		 		 	[***]

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 5

	
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 Medpace Reference Laboratories Fee Estimate 

 

																																									
	Sponsor: Coherus Biosciences	  		  		  		  		  		  	 	[	***] 	 		  		  		  		  		  		  		  			
	Protocol: CHS-0214-02	  		  		  		  		  		  		  				 		  		  		  		  		  		  		  			
																			
		  		  		  		  		  		  		  		  		  		  	 	[	***] 	 		  		  		  		  		  		  		  			
	 	  	 	  	Unit Cost	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	Total
Number
of Units	  	Cost	  	Subtotal	 
	Laboratory Tests	  		  		  		  		  				 		  		  		  		  		  		  		  	 	[***]	  
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  			
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  			
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  			
		  	[***]	  	[***]	  	[***]	  	[***]	  		  		  		  	[***]	  		  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  			
		  	[***]	  	[***]	  	[***]	  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
	Laboratory Support Services	  		  		  		  		  		  				 		  		  		  		  		  		  		  	 	[***]	  
	[***]	  		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
	[***]	  		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  			
		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
	[***]	  		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  			
		  	[***]	  	[***]	  		  	[***]	  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  	[***]	  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  	[***]	  		  		  		  	[***]	  		  	 	[***]	  	 		  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  			
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  			
	Total Medpace Reference Laboratory Fees	  		  				 		  		  		  		  		  		  		  	 	[***]	  

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 6

	
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 Medpace Reference Laboratories Pass Through Estimate 

 

									
	 Sponsor: Coherus Biosciences

Protocol: CHS-0214-02
	  	Average
Cost per Unit	 	Estimated
Number of
Units	 	Total Cost	 	Subtotal
	 Pass Through Estimates
	  		 		 		 	[***]
	 [***]
	  		 		 		 	
	 [***]
	  	[***]	 	[***]	 	[***]	 	
	 [***]
	  	[***]	 	[***]	 	[***]	 	
	 [***]
	  	[***]	 	[***]	 	[***]	 	
	 [***]
	  	[***]	 		 	[***]	 	
	 [***]
	  	[***]	 	[***]	 	[***]	 	
	 [***]
	  		 		 	[***]	 	
	 Total Estimated Medpace Reference Laboratory Pass-Through Fees
	  		 		 		 	[***]

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 7

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 Transportation Costs 
  

																											
	 Country
	  	Sites	  	Number
Screened	  	Number
Randomized	  	Number
Ambient /
Refrigerate
shipments	  	Number
Frozen
Shipments	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 Total
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	  		  	[***]
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  		  		  		  	[***]	  		  	[***]	  		  	[***]	  		  	[***]

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 8

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
	Costs	  	1 Resupplies per site        

  

																											
	 Sites
	  	Number
Screened	  	Number
Randomized	  	Number
Ambient /
Refrigerate
shipments	  	Number
Frozen
Shipments	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	  	
		  		  		  	[***]	  		  		  		  		  		  		  		  		  		  	
		  		  		  	[***]	  		  		  		  		  		  		  		  		  		  	
		  		  		  	[***]	  		  		  		  		  		  		  		  		  		  	
		  		  		  	[***]	  		  		  		  		  		  		  		  		  		  	
		  		  		  	[***]	  		  		  		  		  		  		  		  		  		  	
		  		  		  	[***]	  		  		  		  		  		  		  		  		  		  	
		  		  		  		  		  		  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	  	[***]

  

			
	

	  	 Amendment #3 to Task Order #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA302
 Page 9

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.Prepared by R.R. Donnelley Financial -- EX-10.16(e)

 Exhibit 10.16(e) 

 

CONFIDENTIAL 

[***] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential
treatment has been requested with respect to the omitted portions. 

 AMENDMENT #4 TO TASK ORDER #13 

COHERUS Project Number: CHS-0214-02 

MEDPACE Project Number: ETA302 

This Amendment #4 (“Amendment #4”) to Task Order #13 effective as of October 18, 2013 (“Task
Order”), is by and between Coherus Biosciences, Inc., a Delaware corporation with its principal place of business at 201 Redwood Shores Parkway, Suite 200, Redwood City, CA 94065 (“Sponsor”), and Medpace, Inc.,
with its principal place of business at 5375 Medpace Way, Cincinnati, Ohio 45227 (“Medpace”). This Amendment #4 shall be effective August 19, 2014. 

WITNESSETH: 
 WHEREAS, the Parties
have entered into Task Order pursuant and subject to the terms of the Master Service Agreement dated January 23, 2012, (the “Master Service Agreement”); and subsequent Amendment #1 effective April 23, 2014, and
Amendment #2 effective May 21, 2014, and Amendment #3 effective May 30, 2014, and 
 WHEREAS, the Parties
desire to amend Task Order in connection with A Phase 3, Double-Blind, Randomized, Parallel-Group, Active-Control Study to Compare the Efficacy and Safety of CHS-0214 Versus Enbrel® in
Subjects With Rheumatoid Arthritis and Inadequate Response to Treatment with Methotrexate to modify the Services. 
 NOW,
THEREFORE, in consideration of the mutual covenants contained herein, the Parties hereby agree as follows to the revised Scope of Work. 
  

	1.	As a result of these changes, Appendices A, B, C, D, E, and F in Task Order will be deleted in their entirety and replaced with Appendices A, B, C, D, E, and F attached to this Amendment #4 and
incorporated herein. 

  

	2.	[***] Services and Budget is identified in Appendix G attached to this Amendment #4 and incorporated herein. 

  

	3.	[***] is identified in Appendix H attached to this Amendment #4 and incorporated herein. 

  

	4.	Notwithstanding anything to the contrary in this Task Order and its Appendices or the Master Service Agreement, the Parties agree [***] the Scope of Work (Appendix A) and/or the Services and Budget (Appendix C). In
determining [***], as provided above, the Parties will [***], and incorporated herein. 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

 The total amount payable by Sponsor to Medpace under this Amendment #4 for Medpace Direct Fees, Pass-through
Expenses, and Pre-funded Expenses shall not exceed the amount of [***] without prior written consent of both parties. The total value of Task Order and all subsequent amendments is now [***], as further set forth in the following table: 

 

																	
	 	  	Direct Fees	 	  	Pass Through
Costs	 	  	Pre-funded
Expenses	 	  	TOTAL	 
	 Task Order #13
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 Amendment #1
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 Amendment #2
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 Amendment #3
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 Amendment #4
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 TOTAL
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 

 All other provisions of the Agreement and Task Order shall remain unchanged and in effect. 

IN WITNESS WHEREOF, the Parties have hereunto signed this Amendment #4 to Task Order in their official capacities which shall be effective on the
day and year listed above. 
  

			
	MEDPACE, INC.
		
	Signature:	 	/s/ August Troendle

			
		
	By:	 	August Troendle
		 	(Print Name)
		
	Title:	 	President

  

			
	COHERUS BIOSCIENCES, INC.
		
	Signature:	 	/s/ Dennis M. Lanfear

			
		
	By:	 	Dennis M. Lanfear
		 	(Print Name)
		
	Title:	 	President & CEO

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

													
	 	  	Pass Through	 
	 Version
	  	MRL Labs	 	  	Other	 	  	Total	 
	 Original
	  				  	 	[***]	  	  	 	[***]	  
	 Amendment #1
	  	 	[***]	  	  				  	 	[***]	  
	 Amendment #2
	  				  				  	 	[***]	  
	 Amendment #3
	  	 	[***]	  	  				  	 	[***]	  
	 Amendment #4
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 TOTAL
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
		
	 	  	Pre-Funded	 
	 Version
	  	    [***]    	 	  	Other	 	  	Total	 
	 Original
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 Amendment #1
	  				  				  	 	[***]	  
	 Amendment #2
	  	 	[***]	  	  				  	 	[***]	  
	 Amendment #3
	  				  				  	 	[***]	  
	 Amendment #4
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 TOTAL
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 APPENDIX A: SCOPE OF WORK 
  

			
	 ITEM
	  	 DESCRIPTION

		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]

  

									
	 Investigator Meeting
	  	 Position
	 	  	 Count
	 
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  				  	 	[***]	  

 PROJECT START-UP 

 

									
	 [***]
	  	[***]	  	[***]	  	 ITEM
	  	 DESCRIPTION

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

																	
	 [***]
	  				  				  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
	 [***]
	  				  				  	 	[***]	  	  			
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
		  				  	 	[***]	  	  	 	[***]	  	  			
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
	 [***]
	  				  				  	 	[***]	  	  			
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

															
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

															
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

															
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  

 CLINICAL OPERATIONS 
  

															
	 [***]
	  	[***]	 	  	[***]	  	ITEM	 	  	DESCRIPTION	 
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

															
	 [***]
	  				  		  	 	[***]	  	  			
	 [***]
	  				  		  	 	[***]	  	  			
	 [***]
	  				  		  	 	[***]	  	  			
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
	 [***]
	  				  		  	 	[***]	  	  			
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  			

 CLINICAL MONITORING 
  

															
	 [***]
	  	[***]	 	  	[***]	  	ITEM	 	  	DESCRIPTION	 
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

															
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 CLINICAL SAFETY 
  

															
	 [***]
	  	[***]	 	  	[***]	  	ITEM	 	  	DESCRIPTION	 
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  			

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

															
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  
		  	 	[***]	  	  		  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

									
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]

 RANDOMIZATION AND SUPPLY MANAGEMENT 
  

									
	 [***]
	  	[***]	  	[***]	  	ITEM	  	DESCRIPTION
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and
Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

									
		  	[***]	  		  	[***]	  	[***]

 DATA MANAGEMENT 
  

									
	 [***]
	  	[***]	  	[***]	  	ITEM	  	DESCRIPTION
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

									
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

									
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]
	 [***]
	  		  		  	[***]	  	[***]

 STATISTICAL ANALYSIS 
  

									
	 [***]
	  	[***]	  	[***]	  	ITEM	  	DESCRIPTION
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	
		  	[***]	  		  	[***]	  	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 DATA SAFETY MONITORING BOARD 
  

									
	 [***]
	  	[***]	 	[***]	  	ITEM	  	DESCRIPTION
		  	[***]	 		  	[***]	  	
	 [***]
	  	[***]	 		  	[***]	  	[***]
		  	[***]	 		  	[***]	  	[***]
		  	[***]	 		  	[***]	  	[***]
		  	[***]	 		  	[***]	  	[***]

 MEDICAL WRITING 
  

									
	 [***]
	  	[***]	 	[***]	  	ITEM	  	DESCRIPTION
		  	[***]	 		  	[***]	  	[***]
	 [***]
	  		 		  	[***]	  	
		  	[***]	 		  	[***]	  	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

									
	 [***]
	  		  		  	[***]	  	
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]
		  	[***]	  		  	[***]	  	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 APPENDIX B: TIMELINE 
  

					
	 Task
	  	Date	 
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 APPENDIX C: SERVICES AND BUDGET 
  

					
	Medpace Service Category	  	Fee	 
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

					
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 Total Service Fees
	  	 	[***]	  

  

					
	 Prefunded & Pass-Through Expenses
	  	Fee	 
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

					
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 Total Prefunded & Pass-Through Expenses
	  	 	[***]	  
	 Grand Total of All Fees
	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 APPENDIX D: PAYMENT SCHEDULE 

 

									
	 Payment Schedule

	 Project:
	  	CHS-0214-02 / ETA302	  	Total Direct Fees:	  	[***]	  	
					
	 Sponsor:
	  	Coherus Bioscience, Inc.	  		  		  	

									
					
	 Payment #
	  	 Payment Description/Type
	  	Invoice/Date	  	Amount
to Pay	  	Percentage
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]
	 Total of All Payments:
	  	[***]	  		  	100%

  

	*	[***] 

	**	[***] 

 The payment schedule above includes [***]. For each additional [***]. These units will be [***]. This
unit cost does not include [***]. Pass-through expenses associated [***] will be invoiced [***]. 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 Sponsor paid [***] towards Pre-funded Expenses under Amendment #2 to Task Order #13. Upon execution of this
Amendment #4, Sponsor will pay an additional [***] of the remaining total Pre-funded Expenses due per Appendix C: Services and Budget. Medpace will invoice Sponsor as needed for actual Pre-funded Expenses incurred. Sponsor shall pay such invoice
within [***] of receipt. If sufficient funds are not received from Sponsor, [***]. Medpace shall apply the initial [***] Pre-funded amount paid at execution of this Amendment #4 against the last invoice of actual Pre-funded Expenses, and reconcile
the balance. 
 Pass-through Costs will be billed to Sponsor on a monthly basis or as incurred. Sponsor shall pay such invoice within [***] of receipt. 

Pass-through Costs and Pre-funded Expenses 
 Any sums
quoted with respect to Pass-through Costs and Pre-funded Expenses [***]. While Medpace will [***]. Payments made to third parties are [***]. 
 Pass-through
Costs may include, but are not limited to, [***]. Costs associated with, [***] are as detailed in the table below. 
  

									
	Item	  	Cost*	 	  	Description	 
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	 	[***]	  	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

					
	 [***]
	  	[***]	  	[***]
	 [***]
	  	[***]	  	
	 [***]
	  	[***]	  	
	 [***]
	  	[***]	  	
	 [***]
	  	[***]	  	
	 [***]
	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]

  

	*	Currency is [***]. Costs are subject to change based on fluctuations in supplier prices. 

 Medpace will
pass-through [***]. This will include [***]. 
  

					
	Item	  	Cost	 	Description
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	

  

	*	Currency is [***] 

 Pre-funded Expenses 

Pre-funded Expenses may include, but are not limited to, [***]. Investigator fees are [***]. The investigator fee amount [***]. The laboratory fee amount
[***]. With the exception of [***], Medpace will seek the prior written approval of the budget by Sponsor before signing an agreement (including amendments) with Pre-funded Vendors. 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 Additional Costs 

[***]. 
 All Direct Fees are [***]. Pursuant to Paragraph 3, all
such changes [***]. After staff are assigned, [***]. 
 Inflation 

[***] 
 Currency and Exchange Rate 

The currency of this Task Order is United States Dollars. 

Medpace will invoice Sponsor for Pass-through Costs and Pre-funded Expenses incurred and/or [***]. The Direct Fees detailed in this Task Order were calculated
using [***]. [***]. [***]. 
  

					
	 Country
	  	Currency	 	as of [***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]
	 [***]
	  	[***]	 	[***]

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

					
	 [***]
	  	[***]	 	[***]

 Applicable Taxes 
 All
Direct Fees, Pass-through Costs, and Pre-funded Expenses are quoted excluding any [***], which include but are not limited to [***], which may be payable to Medpace by Sponsor. 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 APPENDIX E: TRANSFER OF OBLIGATIONS 

CONFIDENTIAL 
 Directions: Complete the form below
for Sponsor obligations that have been transferred in accordance with 21 CFR Part 312, Subpart D (Responsibilities of Sponsors). Forward the completed form to Sponsor’s Regulatory Affairs Department for submission to the
applicable regulatory agencies. 
  

			
	 Drug:
	  	CHS-0214 Versus Enbrel® Study ID: CHS-0214-02
		
	 Study Title:
	  	A Phase 3, Double-Blind, Randomized, Parallel-Group, Active-Control Study to Compare the Efficacy and Safety of CHS-0214 Versus Enbrel® in Subjects With Rheumatoid
Arthritis and Inadequate Response to Treatment with Methotrexate
		
	 CRO Name:
	  	Medpace
		
	 CRO Address:
	  	5375 Medpace Way, Cincinnati, Ohio 45227

  

			
	 OBLIGATIONS TRANSFERRED
TO MEDPACE: x THE APPROPRIATE BOX(ES).

	
	
 ̈       All obligations in
21 CFR 312, Subpart D (Responsibilities of Sponsors) have been transferred to Medpace.
  

x       The following obligations
have been transferred to Medpace:

 

 Sec. 312.32: IND Safety Reports 

 

	 ̈	Promptly review safety information. 

  

	x	Notify all participating investigators in a written IND safety report of any AE associated with the drug that is both serious and unexpected. 

 

	 ̈	Notify the FDA in a written IND safety report of any AE associated with the drug that is both serious and unexpected. 

Sec. 312.53: Selecting investigators and monitors 
  

	x	(a) Select qualified investigators 

  

	x	(b) Control investigational drug shipment 

  

	x	(c) Obtain information from investigators 

  

	 	x	(1) Signed Form FDA-1572 

  

	 	x	(2) CV or other qualification statement 

  

	 	x	(3) Clinical protocol outline 

  

	 	x	(4) Financial disclosure information 

  

	x	(d) Select qualified monitors 

 Sec. 312.54: Emergency research 

 

	 ̈	(a) Monitor the progress of all studies involving an exception from informed consent.

 Sec. 312.57: Record keeping and record retention 

 

	x	(a) Maintain adequate records showing investigational drug receipt, shipment, or other disposition. 

  

	x	(b) Maintain complete and accurate records showing any financial interests of the investigator subject to 21 CFR 54. 

  

	x	(c) Retain the records and reports required by the regulations for 2 years after the marketing application is approved, or if not approved, until 2 years after investigational drug shipment is discontinued and
FDA has been notified. 

  

	 ̈	(d) Retain reserve samples of any test article and reference standard identified and used in bioequivalence or bioavailability studies. 

Sec. 312.58: Inspection of Sponsor’s records and reports 
  

	x	(a) Permit FDA personnel to have access to and copy and verify any records and reports related to the clinical

 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

 

	x	(b) Monitor such studies to identify when an IRB determines that it can’t approve the research. 

Sec. 312.55: Informing investigators 
  

	x	(a) Provide sites with the current Inv. Brochure. 

  

	x	(b) Inform investigators of new observations on the drug, particularly with respect to AEs and safe use. 

Sec. 312.56: Review of ongoing investigations 
  

	 ̈	(a) Monitor the progress of all IND studies. 

  

	x	(b) Secure compliance from noncompliant investigators or discontinue drug shipments and end the investigator’s participation in the study. 

 

	x	(c) Review and evaluate the safety and efficacy results as it is obtained from the investigator. 

  

	x	(d) Discontinue use of the investigational drug if it is determined to present an unreasonable and significant risk to subjects, notify all IRBs and investigators, and assure the return or alternate disposition of the
drug from the investigators. 

	 	
investigation. 

  

	x	(b) Permit DEA personnel to have access to and copy records related to the shipment, delivery, receipt and disposition of any investigational controlled substance. Assure adequate storage precautions are taken for
investigational new drug substances listed in any schedule of the Controlled Substances Act. 

 Sec. 312.59: Disposition of unused
supply of investigational drug 
  

	x	Assure the return (or alternate disposition) of all unused supplies of the investigational drug from each discontinued/terminated investigator; maintain written records of any disposition of the investigational drug.

 Other 
  

	 ̈	Please describe any other applicable transfers below: 

 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

 APPENDIX F: MRL AND [***] Services and Budget 

See attached budget on next page. 

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 Sponsor: Coherus Biosciences
            8-Jul-14 
 Protocol: CHS-0214-02 

 

					
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 Total Medpace Reference Laboratories Fees
	  	 	[***]	  

  

			
		  	 Medpace Amendment #4 to TASK ORDER #13

Coherus Biosciences, Inc.
 CHS-0214-02
/ ETA 302

			
		
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

																																									
	 	 	 	 	 	  	Medpace Reference Laboratories Fee Estimate
	 Sponsor: Coherus Biosciences

Protocol: CHS-0214-02
	  		  		  		  		  		  	 	[***]	  	 		  		  		  		  		  		  		  	
																				
		 		 		  		  		  		  		  		  		  		  		  	 	[***]	  	 		  		  		  		  		  		  		  	
	 	 	 	 	 	  	Unit Cost	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	Total
Number
of Units	  	Cost	  	Subtotal
		 		 	Laboratory Tests	  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	[***]
		 		 	 [***]
	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  	[***]	  	[***]	  		  		  		  	[***]	  		  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  	[***]	  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	Laboratory/Support Services	  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	[***]
		 	 [***]
	 		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  	[***]	  	
		 		 	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 	 [***]
	 		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 		 	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 	 [***]
	 		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 		 	 [***]
	  	[***]	  		  	[***]	  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  	[***]	  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  	[***]	  		  		  		  	[***]	  		  	 	[***]	  	 		  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 		 	 [***]
	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  		  		  		  	
		 	 Total Medpace Reference Laboratory Fees
	  		  		  		  				 		  		  		  		  		  		  		  	[***]

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

																																							
	 	  	 	  	Medpace Reference Laboratories Fee Estimate
																
	 Sponsor: Coherus Biosciences

Protocol: CHS-0214-02
	  		  		  		  		  		  		  		  	 	[	***] 	 		  		  		  		  		  		  	
																			
		  		  		  		  		  		  		  		  		  		  		  	 	[	***] 	 		  		  		  		  		  		  	
	 	  	 	  	Unit
Cost	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	 	[***]	  	[***]	  	[***]	  	[***]	  	Total
Number
of Units	  	Cost	  	Subtotal
																
		  	 Laboratory Tests
	  		  		  		  		  		  		  				 		  		  		  		  		  		  	[***]
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  		  		  		  	[***]	  		  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
																
		  	 Laboratory/Support Services
	  		  		  		  		  		  		  				 		  		  		  		  		  		  	[***]
	 [***]
	  		  		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
	 [***]
	  		  		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  	
		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
	 [***]
	  		  		  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  	[***]	  		  		  		  	[***]	  		  	[***]	  				 	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	 	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  		  				 		  		  		  		  		  		  	
	 Total Medpace Reference Laboratory Fees
	  		  		  		  		  		  		  				 		  		  		  		  		  		  	[***]

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

																																							
	 	  	 	  	Medpace Reference Laboratories Fee Estimate
																
	 Sponsor: Coherus Biosciences

Protocol: CHS-0214-02
	  		  		  		  		  		  		  	 	[***]	  	  		  		  		  		  		  		  		  	
																			
		  		  		  		  		  		  		  		  		  		  	 	[***]	  	  		  		  		  		  		  		  		  	
	 	  	 	  	Unit
Cost	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	 	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	Total
Number
of Units	  	Cost	  	Subtotal
																
		  	 Laboratory Tests
	  		  		  		  		  		  				  		  		  		  		  		  		  		  	[***]
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	 	[***]	  	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	 	[***]	  	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  		  		  		  	[***]	  		  	 	[***]	  	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
															
		  	 Laboratory/Support Services
	  		  		  		  		  				  		  		  		  		  		  		  		  	[***]
	 [***]
	  		  		  		  		  		  		  		  		  		  				  		  		  		  		  		  		  		  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
	 [***]
	  		  		  		  		  		  		  		  		  		  				  		  		  		  		  		  		  		  	
		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
	 [***]
	  		  		  		  		  		  		  		  		  		  				  		  		  		  		  		  		  		  	
		  	[***]	  	[***]	  		  	[***]	  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  	[***]	  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  	[***]	  		  		  		  	[***]	  		  	 	[***]	  	  		  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	 	[***]	  	  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  	[***]	  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  		  		  	
		  	[***]	  	[***]	  		  		  		  		  		  		  		  				  		  		  		  		  		  		  		  	
	Total Medpace Reference Laboratory Fees	  		  		  		  		  				  		  		  		  		  		  		  		  	[***]

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 Medpace Reference Laboratories Fee Estimate 

Sponsor: Coherus Biosciences 
 Protocol: CHS-0214-02

  

																			
	 	  	 	  	Average
Cost per Unit	 	  	Estimated
Number of
Units	 	  	Total Cost	 	  	Subtotal	 
		  	Pass Through Estimates	  				  				  				  			
	 [***]
	  		  				  				  				  			
		  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
		  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
		  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
		  	[***]	  	 	[***]	  	  				  	 	[***]	  	  			
		  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
		  	[***]	  				  				  	 	[***]	  	  			
	Total Medpace Reference Laboratory Fees	  	  				  				  	 	[***]	  

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 Transportation Costs—ETA302 Sc. 1 

 

																											
	 Country
	  	Sites	  	Number
Screened	  	Number
Randomized	  	Number
Ambient
&
Refrigerate
shipments	  	Number
Frozen
Shipments	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 Total
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  		  	[***]	  		  	[***]	  		  	[***]	  		  	[***]
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  	[***]	  		  		  		  		  		  	[***]	  	[***]	  		  	
		  		  		  		  		  		  		  	[***]	  		  	[***]	  		  	[***]	  		  	[***]
		  		  		  		  	*[***]	  		  		  		  		  		  		  		  		  	
		  		  		  		  	*[***]	  		  		  		  		  		  		  		  		  	

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

																																																	
	 Country
	  	Sites	 	  	Number
Screened	 	  	Number
Randomized	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	 	 
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  			
	 Total
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  				  	 	[***]	  	  				  	 	[***]	  	  				  	 	[***]	  	  				  	 	[***]	  	  			
		  				  				  				  				  	 	[***]	  	  				  	 	[***]	  	  				  	 	[***]	  	  				  	 	[***]	  	  	 	[***]	  

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 APPENDIX G: [***]. 

See attached budget on next page. 

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 CONFIDENTIAL 
  

	 Medpace, Inc.  
	 Estimation Date: [***] 

Estimate #: [***] 
 Cost
Estimate 
 [***] 

CHS-0214 Etanercept Biosimilar [***] 
  

									
	 ITEMS
	  	Price [***]	 	 	Price [***]	 
	 [***] Services
	  				 			
	 1. [***]
	  	 	[	***] 	 	 	[	***] 
	 2. [***]
	  	 	[	***] 	 	 	[	***] 
	 3. [***]
	  	 	[	***] 	 	 	[	***] 
	 Total
	  	 	[	***] 	 	 	[	***] 
	 [***]
	  				 			
	 1) [***]
	  	 	[	***] 	 	 	[	***] 
	 2) [***]
	  	 	[	***] 	 	 	[	***] 
	 3) [***]
	  				 			
	 Total
	  	 	[	***] 	 	 	[	***] 
	 Grand Total
	  	 	[	***] 	 	 	[	***] 

 Note 
  

	 	-	[***]: [***] 

  

	 	-	[***]: [***] 

  

	 	-	[***] 

  

	 	-	[***] 

  

	 	-	[***] 

  

	 	-	[***] 

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

	 	-	[***] 

  

	 	-	[***] 

  

	 	-	[***] 

 [***] 

[***] 

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
		  	 CONFIDENTIAL
  

Estimation Date: [***]
 Estimate #:
[***]

	 1. [***]
	  	

 Detailed cost estimate 

[***] 
 CHS-0214
Etanercept Biosimilar [***] 
 Total:
                        [***] 
  

													
	 Summary
	  	Unit price [***]	 	  	[***]	 	  	Cost [***]	 
	 I [***]
	  				  				  	 	[***]	  
	 1 [***]
	  				  				  			
	 (1) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (2) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (3) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 2 [***]
	  				  				  	 	[***]	  
	 3 [***]
	  				  				  			
	 (1) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (2) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (3) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 4 [***]
	  				  				  	 	[***]	  
	 5 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 II [***]
	  				  				  	 	[***]	  
	 1 [***]
	  				  				  			
	 (1) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (2) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 2 [***]
	  				  				  	 	[***]	  
	 3 [***]
	  				  				  			
	 (1) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

													
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 iii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 iv) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (2) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 iii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 iv) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 4 [***]
	  				  				  			
	 (1) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (2) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 5 [***]
	  				  				  			
	 (1) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 (2) [***]
	  				  				  			
	 i) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 ii) [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 III [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
		  				  				  	  
	  
	 
	 Total [***]
	  				  				  	 	[***]	  
		  				  				  	  
	  
	 

 Note: 
 –
[***] 
 – [***] 
 –
[***] 

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
		  	 CONFIDENTIAL
  

Estimation Date: [***]
 Estimate #:
[***]

	 2. [***]
	  	

 Detailed cost estimate 

[***] 
 CHS-0214
Etanercept Biosimilar [***] 
 Total:
                        [***] 
  

																									
	 	  	Summary	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	Cost [***]	 
	 I [***]
	  				  				  				  				  				  	 	[***]	  
	 [***]
	  	 	[***] presumably	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	sites	  	  	 	[***]	  
		  	 	[***]	  	  				  				  				  				  			
	 * [***]
	  				  				  				  				  				  			
	 * [***]
	  				  				  				  				  				  			
	 II [***]
	  				  				  				  				  				  	 	[***]	  
	 [***]
	  				  				  				  				  				  	 	[***]	  
	 [***]
	  				  				  				  				  				  			
	 [***]
	  				  				  				  				  				  			
	 • [***]
	  				  				  				  				  				  			
	 • [***]
	  				  				  				  				  				  			
	 [***]
	  				  				  				  				  				  			
	 • [***]
	  				  				  				  				  				  			
	 [***]
	  				  				  				  				  				  			
	 • [***]
	  				  				  				  				  				  			
	 [***]
	  				  				  				  				  				  			
	 • [***]
	  				  				  				  				  				  			
	 • [***]
	  				  				  				  				  				  			
	 III [***]
	  				  				  	 	[***]	  	  	 	[***]	  	  				  	 	[***]	  
		  				  				  				  				  				  	  
	  
	 
		  	 	Total [***]	  	  				  				  				  				  	 	[***]	  
		  				  				  				  				  				  	  
	  
	 
	 V [***]
	  				  				  				  				  				  			
	 1 [***]
	  				  				  				  				  				  			
	 2 [***]
	  				  				  				  				  				  			
	 3 [***]
	  				  				  				  				  				  			
	 4 [***]
	  				  				  				  				  				  			
	 5 [***]
	  				  				  				  				  				  			

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
		  	 CONFIDENTIAL
  

Estimation Date: [***]
 Estimate #:
[***]

	 3. [***]
	  	

 Detailed cost estimate 
  

															
		  	—Assumptions—	  		  		  				  			
	1)	  	[***]:	  	[***]	  	12) [***]: [***]	  				  			
	2)	  	[***]:	  	[***]	  		  				  			
	3)	  	[***]:	  	[***]	  	

[***]:	  				  	 	[***]	  
	4)	  	[***]:	  	[***]	  	

[***]:	  				  	 	[***]	  
	5)	  	[***]:	  	[***]	  	

[***]:	  				  	 	[***]	  
	6)	  	[***]:	  	[***]	  	

[***]:	  				  	 	[***]	  
	7)	  	[***]:	  	[***]	  	

[***]:	  				  	 	[***]	  
	8)	  	[***]	  	[***]	  	

[***]:	  				  	 	[***]	  
	9)	  	[***]:	  	[***]	  		  				  			
		  		  		  	[***]:	  				  	 	[***]	  
		  		  		  		  	 	Total:	  	  	 	[***]	  

  

																									
	 Summary
	  	 	 	 	 	 	 	Unit price [***]	 	 	[***]	 	 	[***]	 	 	Cost [***]	 
	 I [***]
	  				 				 				 				 				 	 	[	***] 
	 1 [***]
	  				 				 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 2 [***]
	  				 				 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
							
	 II [***]
	  				 				 				 				 				 	 	[	***] 
	 1 [***]
	  				 				 				 				 				 			
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 2 [***]
	  				 				 				 				 				 			
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 3 [***]
	  				 				 				 				 				 			
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  				 				 				 				 				 			
	 4 [***]
	  				 				 				 				 				 			
	 [***]
	  				 				 				 				 				 			
	 1) [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 2) [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 3) [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 4) [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  				 				 				 				 				 			
	 1) [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 2) [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 i) [***]
	  				 				 				 				 				 			
	 [***]
	  				 				 				 				 				 			
	 ii) [***]
	  				 				 				 				 				 			
	 [***]
	  				 				 				 				 				 			
	 iii) [***]
	  				 				 				 				 				 			
	 iv) [***]
	  				 				 				 				 				 			
	 v) [***]
	  				 				 				 				 				 			
	 vi) [***]
	  				 				 				 				 				 			
	 vii) [***]
	  				 				 				 				 				 			
	 viii) [***]
	  				 				 				 				 				 			
	 ix) [***]
	  				 				 				 				 				 			
	 x) [***]
	  				 				 				 				 				 			
	 xi) [***]
	  				 				 				 				 				 			
	 xii) [***]
	  				 				 	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  				 				 				 				 				 			

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

																																											
	 4 [***]
	 		  				 				 				 				 				 				 				 				 				 			
	 [***]
	 		  	 	[	***] 	 	 	[	***] 	 				 	 	[	***] 	 				 	 	[	***] 	 	 	[	***] 	 				 				 	 	[***]	  
	 [***]
	 		  				 				 				 				 				 				 				 				 				 			
	 III [***]
	 		  				 				 				 				 				 				 				 				 				 	 	[***]	  
	 1 [***]
	 		  				 				 				 				 				 				 				 				 				 			
	 [***]
	 		  	 	[	***] 	 	 	[	***] 	 				 	 	[	***] 	 				 	 	[	***] 	 	 	[	***] 	 				 				 	 	[***]	  
	 [***]
	 		  	 	[	***] 	 	 	[	***] 	 				 	 	[	***] 	 				 	 	[	***] 	 	 	[	***] 	 				 				 	 	[***]	  
	 [***]
	 		  	 	[	***] 	 	 	[	***] 	 				 	 	[	***] 	 				 	 	[	***] 	 	 	[	***] 	 				 				 	 	[***]	  
	 [***]
	 		  				 				 				 				 				 				 				 				 				 			
	 2 [***]
	 		  				 				 				 				 				 				 				 				 				 			
	 [***]
	 		  	 	[	***] 	 				 	 	[	***] 	 				 				 	 	[	***] 	 				 	 	[	***] 	 	 	[	***] 	 			
	 [***]
	 		  				 				 				 				 				 				 				 				 				 			
	 3 [***]
	 		  				 				 				 				 				 				 				 				 				 			
	 [***]
	 		  	 	[	***] 	 	 	[	***] 	 				 	 	[	***] 	 				 	 	[	***] 	 	 	[	***] 	 				 				 	 	[***]	  
	 [***]
	 		  	 	[	***] 	 	 	[	***] 	 				 	 	[	***] 	 				 	 	[	***] 	 	 	[	***] 	 				 				 	 	[***]	  
	 IV [***]
	 		  				 				 	 	[	***] 	 				 	 	[	***] 	 				 				 				 				 	 	[***]	  
		 		  				 				 				 				 				 				 				 				 				 	  
	  
	 
		 	 Total [***]
	  				 				 				 				 				 				 				 				 				 	 	[***]	  
		 		  				 				 				 				 				 				 				 				 				 	  
	  
	 

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
	Timeline	  	CONFIDENTIAL

 Estimation Date: [***] 

Estimate #: [***] 
 [***], [***]

 [***] 
  

			
	 [***]
	  	5 of 6

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

			
	Actual Expense	  	CONFIDENTIAL

 Estimation Date: [***] 

Estimate #: [***] 
 Actual
expenses 
 Actual expenses: 
  

	(1)	[***] 

	 	1)	[***] 

	 	2)	[***] 

	 	3)	[***] 

  

	(2)	[***] 

	 	1)	[***] 

	 	2)	[***] 

  

	(3)	[***] 

	 	1)	[***] 

	 	2)	[***] 

  

	(4)	[***] 

	 	[***] 

  

	(5)	Others 

	 	1)	[***] 

	 	2)	[***] 

	 	3)	[***] 

  

	(6)	[***] 

	 	[***] 

  

	(7)	[***] 

	 	[***] 

  

	(8)	[***] 

	 	[***] 

  

	(9)	[***] 

	 	[***] 

 [***] 

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.
	  	

 APPENDIX H: [***] 

The table below reflects [***] included in this Amendment #4. Any [***] may require [***]. 

 

																																	
	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 	  	[***]	 
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
									
	 [***]
	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  

 Medpace Amendment #4 to TASK ORDER #13 

Coherus Biosciences, Inc. 

CHS-0214-02 / ETA 302 

  

			
	 [***]  Certain information in this document has been omitted and filed separately with the Securities and Exchange
Commission. Confidential treatment has been requested with respect to the omitted portions.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00235-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00235-of-00352.parquet"}]]