Document:

THIS WARRANT AND THE SHARES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE "ACT") OR ANY APPLICABLE STATE
SECURITIES LAW, AND MAY NOT BE TRANSFERRED EXCEPT (i) PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE ACT OR (ii) UPON FIRST FURNISHING TO THE
COMPANY AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH TRANSFER IS
NOT IN VIOLATION OF THE REGISTRATION REQUIREMENTS OF THE ACT OR ANY APPLICABLE
STATE SECURITIES LAW.

                                 687,500 Shares

                              COMMON STOCK WARRANT

                   For the Purchase of Shares of Common Stock
                                       of
                                SafeScience, Inc.
                          ----------------------------

         THIS CERTIFIES THAT, for value received, Barbara Ann Karmanos Cancer
Institute (the "Holder") or their registered assigns, are entitled to subscribe
for and purchase from SafeScience, Inc., a Nevada corporation (the "Company"),
six hundred eighty-seven thousand five hundred (687,500) fully paid and
non-assessable shares of the Company's Common Stock, par value $.01 per share
("Common Stock"), subject to the terms and conditions set forth herein at a
purchase price of $1.15 per share (the "Exercise Price"). This Warrant shall be
exercisable, subject the vesting requirements in Section 1, until January 26,
2011.

         1. Vesting. The shares of this Warrant shall vest 85,938 shares
quarterly over a period of two years, commencing March 31, 2001;
notwithstanding, however, that 85,934 shares shall vest in the eighth period.

         2. Exercise of Warrant. The rights represented by this Warrant may be
exercised by the holders hereof, in whole or in part (but not as to a fractional
share of Common Stock), by the surrender of this Warrant (with the notice of
exercise form attached hereto as Exhibit 1 (the "Notice of Exercise") duly
executed) at the office of any duly appointed transfer agent for the Common
Stock or at the principal office of the Company and upon payment to the Company,
or for the account of the Company, by cash or certified check or wire transfer,
of the purchase price for such shares in the amount equal to the product of (a)
the Exercise Price, times (b) the number of shares of Common Stock being
purchased.

         3. Delivery of Stock Certificates on Exercise. As soon as practicable
after the exercise of this Warrant in accordance with Section 2 hereof and in
any event within 10 days thereafter, the Company at its expense will cause to be
issued in the name of and delivered to the holder hereof, or as such holder
(upon payment by such holder of any applicable transfer taxes) may direct, a
certificate or certificates for the number of shares of Common Stock to which
such holder shall be entitled on such exercise, and, unless this Warrant has
expired or has been

<PAGE>

exercised in full, a new Warrant representing the number of shares with respect
to which this Warrant shall not then have been exercised shall also be issued to
the holder hereof at such time. The Holders of this Warrant acknowledges that
the certificate or certificates representing the shares of stock issuable upon
the exercise of this Warrant shall be stamped or otherwise imprinted with a
legend substantially in the following form:

                  "The securities represented by this certificate have not been
              registered under the Securities Act of 1933, as amended, or the
              securities laws of any state. The securities have been acquired
              for investment and may not be sold, offered for sale or
              transferred in the absence of an effective registration under the
              Securities Act of 1933, as amended, and any applicable state
              securities laws or an opinion of counsel satisfactory in form and
              substance to counsel for the Company that the transaction shall
              not result in a violation of state or federal securities laws."

         Upon the request of a holder of a certificate representing shares of
Common Stock purchased upon exercise of this Warrant, the Company shall remove
the foregoing legend from the certificate or issue to such holder a new
certificate therefor free of any transfer legend, if, with such request, the
Company shall have received an opinion of counsel reasonably satisfactory to the
Company to the effect that such legend may be removed from such certificate.

         4. Shares to be Issued, Reservation of Shares; Holders of Record.

              (a) Shares to be Issued. The Company covenants and agrees that all
shares which may be issued upon the exercise of the rights represented by this
Warrant will, upon issuance, be validly authorized, issued and outstanding,
fully paid and non-assessable, and free from all taxes, liens and charges with
respect to the issue thereof.

              (b) Reservation of Common Stock. The Company covenants and agrees
that, during the period within which the rights represented by this Warrant may
be exercised, the Company will at all times have authorized and reserved a
sufficient number of shares of its Common Stock to provide for the exercise of
the rights represented by this Warrant.

              (c) Holders of Record. Each person or entity in whose name any
certificate for shares of Common Stock is issued upon the exercise of this
Warrant in accordance with its terms shall for all purposes be deemed to have
become the holder of record of the shares of Common Stock represented thereby
on, and such certificate shall be dated, the date upon which the Notice of
Exercise was duly executed and payment of the aggregate Exercise Price was made
pursuant to Section 2 hereof. Prior to the exercise of this Warrant, the holder
hereof shall not be entitled to any rights of a stockholder of the Company with
respect to the shares of Common Stock for which this Warrant shall be
exercisable, including, without limitation, the right to vote, to receive
dividends or other distributions or to exercise any preemptive rights and shall
not be entitled to receive any notice of any proceedings of the Company, except
as provided herein.

         5. Adjustment of Exercise Price. The Exercise Price in effect from time
to time shall be subject to adjustment as follows:

              (a) Adjustment for Common Stock Dividends; Subdivisions and
Combinations.

                                      -2
<PAGE>

Upon the issuance of additional shares of Common Stock as a dividend or other
distribution on outstanding Common Stock, the subdivision of outstanding shares
of Common Stock into a greater number of shares of Common Stock, or the
combination of outstanding shares of Common Stock into a smaller number of
shares of the Common Stock, the number of shares of Common Stock purchasable
hereunder shall be proportionately adjusted to the nearest whole share and the
Exercise Price shall be proportionately decreased in the case of a dividend,
split or subdivision and proportionately increased in the case of a combination.
An adjustment made pursuant to this Section 5(a) shall be given effect, upon
payment of such a dividend or distribution, as of the record date for the
determination of stockholders entitled to receive such dividend or distribution
(on a retroactive basis) and in the case of a subdivision or combination shall
become effective immediately as of the effective date thereof.

              (b) Adjustments for Capital Reorganizations. If any capital
reorganization or reclassification of the capital stock of the Company shall be
effected, whether by merger, consolidation, sale of assets or otherwise (other
than a subdivision or combination of shares or stock dividend as provided for
above) (in each case, a "Reorganization"), then, as a condition of such
Reorganization, lawful and adequate provision shall be made whereby the holder
hereof shall thereafter have the right to purchase and receive upon the basis
and upon the terms and conditions specified in this Warrant, in lieu of shares
of Common Stock of the Company immediately theretofore purchasable and
receivable upon the exercise of the rights represented hereby, those shares of
stock, securities or assets which would have been issued or payable with respect
to or in exchange for the Common Stock issuable upon exercise of this Warrant
had this Warrant been exercised immediately prior to the record date (or the
effective date, as the case may be) for such Reorganization. Upon any
Reorganization this Warrant shall continue in full force and effect and the
terms hereof shall be applicable to the shares and other securities and property
receivable on the exercise of this Warrant after the consummation of such
Reorganization and shall be binding upon the issuer of any such stock or other
securities, including the person acquiring all or substantially all of the
properties or assets of the Company, whether or not such person shall have
expressly assumed the terms of this Warrant.

              (c) Other Adjustments. In the event the Company shall make or
issue, or fix a record date for the determination of holders of Common Stock
entitled to receive, a dividend or other distribution payable in securities of
the Company other than shares of Common Stock, then and in each such event
lawful and adequate provision shall be made so that the holders of Warrants
shall receive upon exercise thereof in addition to the number of shares of
Common Stock receivable thereupon, the number of securities of the Company which
such holders would have received had such Warrants been exercised on the date of
such event and had such holders thereafter, during the period from the date of
such event to and including the date of exercise, retained such securities
receivable by such holders as aforesaid during such period, giving application
to all adjustments called for during such period under this Section 5 as applied
to such distributed securities.

              (d) Notices of Adjustments. In each case of an adjustment pursuant
to this Section 5, the Company, at its expense, will furnish the holder of this
Warrant with a certificate, prepared by the chief financial officer of the
Company, showing such adjustment or readjustment, and the number of shares of
Common Stock or other securities and the amount, if any, of other property that
at the time would be received upon the exercise of this Warrant.

                                      -3-
<PAGE>

              (e) Notices of Record Date. In the event (i) the Company
establishes a record date to determine the holders of any class of securities
who are entitled to receive any dividend or other distribution or (ii) there
occurs any capital reorganization of the Company, any reclassification or
recapitalization of the capital stock of the Company, any merger or
consolidation of the Company, any acquisition of the Company, any transfer of
all or substantially all of the assets of the Company to any other Company
entity or person, any sale of a majority of the voting securities of the Company
in one or a series of related transactions or any voluntary or involuntary
dissolution, liquidation or winding up of the Company, the Company shall give to
the holder hereof a notice specifying (a) the date of such record date for the
purpose of such dividend or distribution and a description of such dividend or
distribution, (b) the date on which any such reorganization, reclassification,
transfer, consolidation, merger, acquisition, sale, dissolution, liquidation or
winding up is expected to become effective, and (c) the time, if any, that is to
be fixed, as to when the holders of record of Common Stock (or other securities)
shall be entitled to exchange their shares of Common Stock (or other securities)
for securities or other property deliverable upon such reorganization,
reclassification, transfer, consolidation, merger, acquisition, sale,
dissolution, liquidation or winding up. Such written notice shall be given to
the holder of this Warrant at least fifteen (15) days prior to the date
specified in such notice on which any such action is to be taken.

         6. Holder Representations and Warranties. The Holder of this Warrant
understands the risks of investing in emerging companies such as the Company and
can afford a loss of its entire investment. The Holder is acquiring the Warrant
for investment and not with the view to, or for resale in connection with, any
distribution thereof. The Holder understands that the Warrant and the shares of
Common Stock issuable upon exercise thereof have not been registered under the
Securities Act of 1933, as amended (the "Securities Act"), or any applicable
state securities ("blue sky") laws, by reason of specified exemptions from the
registration provisions of the Securities Act and such laws. The Holder
acknowledges that the Warrant and the shares of Common Stock issuable upon
exercise thereof must be held indefinitely unless they are subsequently
registered under the Securities Act or an exemption from such registration is
available. The Holder hereof has been advised or is aware of the provisions of
Rule 144 promulgated under the Securities Act, which permits the resale of
shares purchased in a private placement subject to the satisfaction of certain
conditions and that such Rule may not be available for resale of the shares.

         7. Transfer. Subject to compliance with applicable securities laws,
this Warrant and all rights hereunder are transferable, in whole or in part, at
the offices referred to in paragraph 2 hereof by the holder in person or by a
duly authorized attorney, upon surrender of this Warrant properly endorsed. Each
taker and holder of this Warrant, by taking or holding the same, consents and
agrees that this Warrant, when endorsed in blank, shall be deemed negotiable and
that when this Warrant is so endorsed, the holder hereof may be treated by the
Company and all other persons dealing with this Warrant as the absolute owner
hereof for any purposes and as the person entitled to exercise the rights
represented by this Warrant or to the transfer hereof on the books of the
Company, any notice to the contrary notwithstanding; but until each transfer on
such books, the Company may treat the registered holder hereof as the owner
hereof for all purposes.

         8. Exchange. Subject to compliance with applicable securities laws,
this Warrant is

                                      -4-
<PAGE>

exchangeable, upon the surrender hereof by the holder hereof at such offices for
new Warrants of like tenor representing in the aggregate the right to subscribe
for and purchase the number of shares which may be subscribed for and purchased
hereunder, each of such new Warrants to represent the right to subscribe for and
purchase such number of shares as shall be designated by such holder hereof at
the time of such surrender. Upon receipt of evidence satisfactory to the Company
of the loss, theft, destruction or mutilation of this Warrant and, in the case
of any such loss, theft or destruction, upon delivery of a bond of indemnity
satisfactory to the Company, or, in the case of any such mutilation, upon
surrender or cancellation of this Warrant, the Company will issue to the holder
hereof a new Warrant of like tenor, in lieu of this Warrant, representing the
right to subscribe for and purchase the number of shares which may be subscribed
for and purchased hereunder.

         9. Registration Rights. The shares issuable upon exercise of this
Warrant shall have the registration rights described in Section 3.2(c) of the
License Agreement dated January 26, 2001 (the "License Agreement") by and among
the Company and the Holders. The Company may postpone the filing of any
registration statement required pursuant to the License Agreement for a
reasonable period of time, not to exceed sixty (60) days in the aggregate, and
not more than once in any ninety (90) day period, if the Company has been
advised by legal counsel in writing, with a copy to the undersigned upon their
request, that such filing would require a special audit or the disclosure of a
material impending transaction or other matter and the Board of Directors of the
Company determines reasonably and in good faith that such disclosure would have
a material adverse effect on the Company.

         10. Notices. Notices or demands relating to this Warrant shall be
sufficiently given or made if sent by prepaid air express courier with regular
service to the addressee, or telexed, telecopied or hand-delivered, if to the
Company, at the address of its principal office or if to the holder of this
Warrant, at its address registered on the books of the Company.

         11. No Impairment. The Company will not, by amendment of its Charter or
by any other voluntary action, avoid or seek to avoid the observance or
performance of any of the terms of this Warrant, but will at all times in good
faith assist in the carrying out of all such terms and in the taking of all such
action as may be necessary or appropriate in order to protect the rights of the
Holder of this Warrant against impairment.

         12. No Rights or Liabilities as a Stockholder. This Warrant shall not
entitle the Holders hereof to any voting rights or other rights as a stockholder
of the Company. No provision of this Warrant, in the absence of affirmative
action by the holder hereof to purchase Common Stock, and no mere enumeration
herein of the rights or privileges of the holder hereof, shall give rise to any
liability of such holder for the Exercise Price or as a stockholder of the
Company, whether such liability is asserted by the Company or by creditors of
the Company.

         13. Miscellaneous. The provisions of this Warrant may be amended or
waived by an instrument in writing signed by the party against which enforcement
of such amendment or waiver is sought. This Warrant shall be construed and
enforced in accordance with and governed by the laws of The Commonwealth of
Massachusetts. The headings in this Warrant are for purposes of reference only,
and shall not limit or otherwise affect any of the terms hereof. The invalidity
or unenforceability of any provision hereof shall in no way affect the validity
or enforceability of any other provision.

                                      -5-
<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
a duly authorized officer as of January 26, 2001.

                                            SAFESCIENCE, INC.

                                            By:  /s/Bradley Carver
                                                 -------------------------------
                                                  Bradley Carver, President

ACCEPTED AND AGREED:

BARBARA ANN KARMANOS CANCER INSTITUTE

By: /s/ Illegible
   -----------------------------------------
Name:
Title

Date:
     ---------------------------------------

<PAGE>

                                    EXHIBIT 1

                               NOTICE OF EXERCISE

   (To be Executed by the Registered Holder in Order to Exercise the Warrant)

         1. The undersigned hereby irrevocably elects to purchase _____________
(________) shares of the Common Stock, $.01 par value per share, SafeScience,
Inc., pursuant to the Warrant Agreement between the Company and the undersigned
dated January 26, 2001 and according to the terms thereof, and herewith makes
payment of the Exercise Price of such shares in full.

         2.       Such payment is hereby made in the amount of by wire transfer
or by certified or bank check.

         3. Please issue a certificate or certificates representing said shares
of Common Stock in the name of the undersigned or in such other name as is
specified below:

                                               ---------------------------------
                                               (Name)

                                               ---------------------------------
                                               (Address)

                                               ---------------------------------
                                               Signature

Dated:
        ----------

                                               ---------------------------------
                                               (Name)

                                               ---------------------------------
                                               (Address)

                                               ---------------------------------
                                               Signature

Dated:
        ----------NEITHER THESE SECURITIES NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE
EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR
THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM
REGISTRATION UNDER SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT"),
AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE
EXEMPTION FROM THE REGISTRATION REQUIREMENTS THEREUNDER AND IN COMPLIANCE WITH
APPLICABLE STATE SECURITIES OR BLUE SKY LAWS.

                                SAFESCIENCE, INC.

                                     WARRANT
                                     -------

Warrant No. __                                          Dated:  February 2, 2001

         SafeScience, Inc., a Nevada corporation (the "Company"), hereby
certifies that, for value received, Montrose Investment Ltd., or its registered
assigns ("Holder"), is entitled, subject to the terms set forth below, to
purchase from the Company up to a total of 380,000 shares of common stock, $.01
par value per share (the "Common Stock"), of the Company (each such share, a
"Warrant Share" and all such shares, the "Warrant Shares") at an exercise price
equal to $1.75 per share (as adjusted from time to time as provided in Section
8, the "Exercise Price"), at any time and from time to time from and after the
date hereof and through and including February 2, 2006 (the "Expiration Date"),
and subject to the following terms and conditions:

         1. Registration of Warrant. The Company shall register this Warrant,
upon records to be maintained by the Company for that purpose (the "Warrant
Register"), in the name of the record Holder hereof from time to time. The
Company may deem and treat the registered Holder of this Warrant as the absolute
owner hereof for the purpose of any exercise hereof or any distribution to the
Holder, and for all other purposes, and the Company shall not be affected by
notice to the contrary.

         2. Registration of Transfers and Exchanges.

              (a) The Company shall register the transfer of any portion of this
Warrant in the Warrant Register, upon surrender of this Warrant, with the Form
of Assignment attached hereto duly completed and signed, to the Transfer Agent
or to the Company at its address for notice set forth in Section 12. Upon any
such registration or transfer, a new warrant to purchase Common Stock, in
substantially the form of this Warrant (any such new warrant, a "New Warrant"),
evidencing the portion of this Warrant so transferred shall be issued to the
transferee and a New Warrant evidencing the remaining portion of this Warrant
not so transferred, if any, shall be issued to the transferring Holder. The
acceptance of the New Warrant by the transferee

<PAGE>

thereof shall be deemed the acceptance of such transferee of all of the rights
and obligations of a holder of a Warrant.

              (b) This Warrant is exchangeable, upon the surrender hereof by the
Holder to the office of the Company at its address for notice set forth in
Section 12 for one or more New Warrants, evidencing in the aggregate the right
to purchase the number of Warrant Shares which may then be purchased hereunder.
Any such New Warrant will be dated the date of such exchange.

         3. Duration and Exercise of Warrants.

              (a) This Warrant shall be exercisable by the registered Holder on
any business day before 6:30 P.M., New York City time, at any time and from time
to time on or after the date hereof to and including the Expiration Date. At
6:30 P.M., New York City time on the Expiration Date, the portion of this
Warrant not exercised prior thereto shall be and become void and of no value.
Prior to the Expiration Date, the Company may not call or otherwise redeem this
Warrant without the prior written consent of the Holder.

              (b) Upon surrender of this Warrant, with the Form of Election to
Purchase attached hereto duly completed and signed, to the Company at its
address for notice set forth in Section 12 and upon payment of the Exercise
Price multiplied by the number of Warrant Shares that the Holder intends to
purchase hereunder, in the manner provided hereunder, all as specified by the
Holder in the Form of Election to Purchase, the Company shall promptly (but in
no event later than four (4) business days after the Date of Exercise (as
defined herein)) issue or cause to be issued and cause to be delivered to or
upon the written order of the Holder and in such name or names as the Holder may
designate, a certificate for the Warrant Shares issuable upon such exercise,
free of restrictive legends except (i) either in the event that a registration
statement covering the resale of the Warrant Shares and naming the Holder as a
selling stockholder thereunder is not then effective or the Warrant Shares are
not freely transferable without volume restrictions pursuant to Rule 144(k)
promulgated under the Securities Act of 1933, as amended (the "Securities Act"),
or (ii) if this Warrant shall have been issued pursuant to a written agreement
between the original Holder and the Company, as required by such agreement. Any
person so designated by the Holder to receive Warrant Shares shall be deemed to
have become holder of record of such Warrant Shares as of the Date of Exercise
of this Warrant. The Company shall, upon request of the Holder, if available,
use its best efforts to deliver Warrant Shares hereunder electronically through
the Depository Trust Corporation or another established clearing corporation
performing similar functions.

                  A "Date of Exercise" means the date on which the Company shall
have received (i) this Warrant (or any New Warrant, as applicable), with the
Form of Election to Purchase attached hereto (or attached to such New Warrant)
appropriately completed and duly signed, and (ii) payment of the Exercise Price
for the number of Warrant Shares so indicated by the holder hereof to be
purchased.

                                      -2-
<PAGE>

              (c) This Warrant shall be exercisable, either in its entirety or,
from time to time, for a portion of the number of Warrant Shares. If less than
all of the Warrant Shares which may be purchased under this Warrant are
exercised at any time, the Company shall issue or cause to be issued, at its
expense, a New Warrant evidencing the right to purchase the remaining number of
Warrant Shares for which no exercise has been evidenced by this Warrant.

         4. Piggyback Registration Rights. During the Effectiveness Period (as
defined in the Registration Rights Agreement dated March 29, 2000 between the
Company and the original Holder), the Company may not file any registration
statement with the Securities and Exchange Commission (other than registration
statements of the Company filed on Form S-8 or Form S-4, each as promulgated
under the Securities Act, pursuant to which the Company is registering
securities pursuant to a Company employee benefit plan or pursuant to a merger,
acquisition or similar transaction including supplements thereto, but not
additionally filed registration statements in respect of such securities) at any
time when there is not an effective registration statement covering the resale
of the Warrant Shares and naming the Holder as a selling stockholder thereunder,
unless the Company provides the Holder with not less than 15 days notice of its
intention to file such registration statement and provides the Holder the option
to include any or all of the applicable Warrant Shares therein. The piggyback
registration rights granted to the Holder pursuant to this Section shall
continue until all of the Holder's Warrant Shares have been sold in accordance
with an effective registration statement or upon the Expiration Date. The
Company will pay all registration expenses in connection therewith.

         5. Payment of Taxes. The Company will pay all documentary stamp taxes
attributable to the issuance of Warrant Shares upon the exercise of this
Warrant; provided, however, that the Company shall not be required to pay any
tax which may be payable in respect of any transfer involved in the registration
of any certificates for Warrant Shares or Warrants in a name other than that of
the Holder. The Holder shall be responsible for all other tax liability that may
arise as a result of holding or transferring this Warrant or receiving Warrant
Shares upon exercise hereof.

         6. Replacement of Warrant. If this Warrant is mutilated, lost, stolen
or destroyed, the Company shall issue or cause to be issued in exchange and
substitution for and upon cancellation hereof, or in lieu of and substitution
for this Warrant, a New Warrant, but only upon receipt of evidence reasonably
satisfactory to the Company of such loss, theft or destruction and indemnity, if
requested, satisfactory to it. Applicants for a New Warrant under such
circumstances shall also comply with such other reasonable regulations and
procedures and pay such other reasonable charges as the Company may prescribe.

         7. Reservation of Warrant Shares. The Company covenants that it will at
all times reserve and keep available out of the aggregate of its authorized but
unissued Common Stock, solely for the purpose of enabling it to issue Warrant
Shares upon exercise of this Warrant as herein provided, the number of Warrant
Shares which are then issuable and deliverable upon the exercise of this entire
Warrant, free from preemptive rights or any other actual contingent

                                      -3-
<PAGE>

purchase rights of persons other than the Holder (taking into account the
adjustments and restrictions of Section 8). The Company covenants that all
Warrant Shares that shall be so issuable and deliverable shall, upon issuance
and the payment of the applicable Exercise Price in accordance with the terms
hereof, be duly and validly authorized, issued and fully paid and nonassessable.

         8. Certain Adjustments. The Exercise Price and number of Warrant Shares
issuable upon exercise of this Warrant are subject to adjustment from time to
time as set forth in this Section 8. Upon each such adjustment of the Exercise
Price pursuant to this Section 8, the Holder shall thereafter prior to the
Expiration Date be entitled to purchase, at the Exercise Price resulting from
such adjustment, the number of Warrant Shares obtained by multiplying the
Exercise Price in effect immediately prior to such adjustment by the number of
Warrant Shares issuable upon exercise of this Warrant immediately prior to such
adjustment and dividing the product thereof by the Exercise Price resulting from
such adjustment.

              (a) If the Company, at any time while this Warrant is outstanding,
(i) shall pay a stock dividend (except scheduled dividends paid on outstanding
preferred stock as of the date hereof which contain a stated dividend rate) or
otherwise make a distribution or distributions on shares of its Common Stock or
on any other class of capital stock payable in shares of Common Stock, (ii)
subdivide outstanding shares of Common Stock into a larger number of shares, or
(iii) combine outstanding shares of Common Stock into a smaller number of
shares, the Exercise Price shall be multiplied by a fraction of which the
numerator shall be the number of shares of Common Stock (excluding treasury
shares, if any) outstanding before such event and of which the denominator shall
be the number of shares of Common Stock (excluding treasury shares, if any)
outstanding after such event. Any adjustment made pursuant to this Section shall
become effective immediately after the record date for the determination of
stockholders entitled to receive such dividend or distribution and shall become
effective immediately after the effective date in the case of a subdivision or
combination, and shall apply to successive subdivisions and combinations.

              (b) In case of any reclassification of the Common Stock or any
compulsory share exchange pursuant to which the Common Stock is converted into
other securities, cash or property, then the Holder shall have the right
thereafter to exercise this Warrant only into the shares of stock and other
securities and property receivable upon or deemed to be held by holders of
Common Stock following such reclassification or share exchange, and the Holder
shall be entitled upon such event to receive such amount of securities or
property equal to the amount of Warrant Shares such Holder would have been
entitled to had such Holder exercised this Warrant immediately prior to such
reclassification or share exchange. The terms of any such reclassification or
share exchange shall include such terms so as to continue to give to the Holder
the right to receive the securities or property set forth in this Section 8(b)
upon any exercise following any such reclassification or share exchange.

                                      -4-
<PAGE>

              (c) If the Company, at any time while this Warrant is outstanding,
shall distribute to all holders of Common Stock (and not to holders of this
Warrant) evidences of its indebtedness or assets or rights or warrants to
subscribe for or purchase any security (excluding those referred to in Sections
8(a), (b) and (d)), then in each such case the Exercise Price shall be
determined by multiplying the Exercise Price in effect immediately prior to the
record date fixed for determination of stockholders entitled to receive such
distribution by a fraction of which the denominator shall be the Exercise Price
determined as of the record date mentioned above, and of which the numerator
shall be such Exercise Price on such record date less the then fair market value
at such record date of the portion of such assets or evidence of indebtedness so
distributed applicable to one outstanding share of Common Stock as determined by
the Company's independent certified public accountants that regularly examines
the financial statements of the Company (an "Appraiser").

              (d) Except for (i) the issuance of shares of Common Stock and
warrants to purchase Common Stock for an aggregate purchase price of up to
$12,000,000 pursuant to a private placement memorandum dated January 29, 2001
and (ii) the issuance of options or warrants to employees, officers and
directors, and the issuance of shares upon exercise of options or warrants
issued, under any stock option plan heretofore or hereinafter duly adopted by
the Company, the Company or any subsidiary thereof, as applicable with respect
to Common Stock Equivalents (as defined below), at any time while this Warrant
is outstanding, shall issue shares of Common Stock or rights, warrants, options
or other securities or debt that is convertible into or exchangeable for shares
of Common Stock ("Common Stock Equivalents"), entitling any person to acquire
shares of Common Stock at a price per share less than the Exercise Price (if the
holder of the Common Stock or Common Stock Equivalent so issued shall at any
time, whether by operation of purchase price adjustments, reset provisions,
floating conversion, exercise or exchange prices or otherwise, or due to
warrants, options or rights issued in connection with such issuance, be entitled
to receive shares of Common Stock at a price less than the Exercise Price, such
issuance shall be deemed to have occurred for less than the Exercise Price),
then the Exercise Price shall be multiplied by a fraction, the numerator of
which shall be the number of shares of Common Stock outstanding immediately
prior to the issuance of such Common Stock or such Common Stock Equivalents plus
the number of shares of Common Stock which the offering price for such shares of
Common Stock or Common Stock Equivalents would purchase at the Exercise Price,
and the denominator of which shall be the sum of the number of shares of Common
Stock outstanding immediately prior to such issuance plus the number of shares
of Common Stock so issued or issuable, provided, that for purposes hereof, all
shares of Common Stock that are issuable upon conversion, exercise or exchange
of Common Stock Equivalents shall be deemed outstanding immediately after the
issuance of such Common Stock Equivalents. Such adjustment shall be made
whenever such Common Stock or Common Stock Equivalents are issued. However, upon
the expiration of any Common Stock Equivalents the issuance of which resulted in
an adjustment in the Exercise Price pursuant to this Section, if any such Common
Stock Equivalents shall expire and shall not have been exercised, the Exercise
Price shall immediately upon such expiration be recomputed and effective
immediately upon such expiration be increased to the price which it would have
been (but reflecting any other

                                      -5-
<PAGE>

adjustments in the Exercise Price made pursuant to the provisions of this
Section after the issuance of such Common Stock Equivalents) had the adjustment
of the Exercise Price made upon the issuance of such Common Stock Equivalents
been made on the basis of offering for subscription or purchase only that number
of shares of the Common Stock actually purchased upon the exercise of such
Common Stock Equivalents actually exercised.

              (e) In case of any (1) merger or consolidation of the Company with
or into another Person, or (2) sale by the Company of more than one-half of the
assets of the Company (on a book value basis) in one or a series of related
transactions, the Holder shall have the right thereafter to exercise this
Warrant for the shares of stock and other securities, cash and property
receivable upon or deemed to be held by holders of Common Stock following such
merger, consolidation or sale, and the Holder shall be entitled upon such event
or series of related events to receive such amount of securities, cash and
property as the Common Stock for which this Warrant could have been exercised
immediately prior to such merger, consolidation or sales would have been
entitled. The terms of any such merger, sale or consolidation shall include such
terms so as continue to give the Holder the right to receive the securities,
cash and property set forth in this Section upon any conversion or redemption
following such event. This provision shall similarly apply to successive such
events.

              (f) For the purposes of this Section 8, the following clauses
shall also be applicable:

                    (i)  Record Date. In case the Company shall take a record of
                         the holders of its Common Stock for the purpose of
                         entitling them (A) to receive a dividend or other
                         distribution payable in Common Stock or in securities
                         convertible or exchangeable into shares of Common
                         Stock, or (B) to subscribe for or purchase Common Stock
                         or securities convertible or exchangeable into shares
                         of Common Stock, then such record date shall be deemed
                         to be the date of the issue or sale of the shares of
                         Common Stock deemed to have been issued or sold upon
                         the declaration of such dividend or the making of such
                         other distribution or the date of the granting of such
                         right of subscription or purchase, as the case may be.

                    (ii) Treasury Shares. The number of shares of Common Stock
                         outstanding at any given time shall not include shares
                         owned or held by or for the account of the Company, and
                         the disposition of any such shares shall be considered
                         an issue or sale of Common Stock.

              (g) All calculations under this Section 8 shall be made to the
nearest cent or the nearest 1/100th of a share, as the case may be.

                                      -6-
<PAGE>

              (h) Whenever the Exercise Price is adjusted pursuant to Section
8(c) above, the Holder, after receipt of the determination by the Appraiser,
shall have the right to select an additional appraiser (which shall be a
nationally recognized accounting firm), in which case the adjustment shall be
equal to the average of the adjustments recommended by each of the Appraiser and
such appraiser. The Holder shall promptly mail or cause to be mailed to the
Company, a notice setting forth the Exercise Price after such adjustment and
setting forth a brief statement of the facts requiring such adjustment. Such
adjustment shall become effective immediately after the record date mentioned
above.

                    (i)  If:

                    (i)  the Company shall declare a dividend (or any other
                         distribution) on its Common Stock; or

                    (ii) the Company shall declare a special nonrecurring cash
                         dividend on or a redemption of its Common Stock; or

                    (iii) the Company shall authorize the granting to all
                         holders of the Common Stock rights or warrants to
                         subscribe for or purchase any shares of capital stock
                         of any class or of any rights; or

                    (iv) the approval of any stockholders of the Company shall
                         be required in connection with any reclassification of
                         the Common Stock, any consolidation or merger to which
                         the Company is a party, any sale or transfer of all or
                         substantially all of the assets of the Company, or any
                         compulsory share exchange whereby the Common Stock is
                         converted into other securities, cash or property; or

                    (v)  the Company shall authorize the voluntary dissolution,
                         liquidation or winding up of the affairs of the
                         Company,

then the Company shall cause to be mailed to each Holder at their last addresses
as they shall appear upon the Warrant Register, at least 20 calendar days prior
to the applicable record or effective date hereinafter specified, a notice
stating (x) the date on which a record is to be taken for the purpose of such
dividend, distribution, redemption, rights or warrants, or if a record is not to
be taken, the date as of which the holders of Common Stock of record to be
entitled to such dividend, distributions, redemption, rights or warrants are to
be determined or (y) the date on which such reclassification, consolidation,
merger, sale, transfer or share exchange is expected to become effective or
close, and the date as of which it is expected that holders of Common Stock of
record shall be entitled to exchange their shares of Common Stock for
securities, cash or other property deliverable upon such reclassification,
consolidation, merger, sale, transfer, share exchange, dissolution, liquidation
or winding up; provided, however, that the failure to mail such notice or any
defect therein or in the mailing thereof shall not affect the validity of the
corporate action required to be specified in such notice.

                                      -7-
<PAGE>

         9. Payment of Exercise Price. The Holder shall pay the Exercise Price
in cash or immediately available funds.

         10. Certain Exercise Restrictions

              (a) A Holder may not exercise this Warrant to the extent such
exercise would result in the Holder, together with any affiliate thereof,
beneficially owning (as determined in accordance with Section 13(d) of the
Securities Exchange Act of 1934, as amended (the "Exchange Act") and the rules
promulgated thereunder) in excess of 4.999% of the then issued and outstanding
shares of Common Stock, including shares issuable upon such exercise and held by
such Holder after application of this Section. Since the Holder will not be
obligated to report to the Company the number of shares of Common Stock it may
hold at the time of an exercise hereunder, unless the exercise at issue would
result in the issuance of shares of Common Stock in excess of 4.999% of the then
outstanding shares of Common Stock without regard to any other shares which may
be beneficially owned by the Holder or an affiliate thereof, the Holder shall
have the authority and obligation to determine whether the restriction contained
in this Section will limit any particular exercise hereunder and to the extent
that the Holder determines that the limitation contained in this Section
applies, the determination of which portion of this Warrant is exercisable shall
be the responsibility and obligation of the Holder. If the Holder has delivered
a Form of Election to Purchase for a number of Warrant Shares that, without
regard to any other shares that the Holder or its affiliates may beneficially
own, would result in the issuance in excess of the permitted amount hereunder,
the Company shall notify the Holder of this fact and shall honor the exercise
for the maximum portion of this Warrant permitted to be exercised on such Date
of Exercise in accordance with the periods described herein and, at the option
of the Holder, either keep the portion of the Warrant tendered for exercise in
excess of the permitted amount hereunder for future exercises or return such
excess portion of the Warrant to the Holder. The provisions of this Section may
be waived by a Holder (but only as to itself and not to any other Holder) upon
not less than 61 days prior notice to the Company. Other Holders shall be
unaffected by any such waiver.

              (b) A Holder may not exercise this Warrant to the extent such
exercise would result in the Holder, together with any affiliate thereof,
beneficially owning (as determined in accordance with Section 13(d) of the
Exchange Act and the rules promulgated thereunder) in excess of 9.999% of the
then issued and outstanding shares of Common Stock, including shares issuable
upon such exercise and held by such Holder after application of this Section.
Since the Holder will not be obligated to report to the Company the number of
shares of Common Stock it may hold at the time of an exercise hereunder, unless
the exercise at issue would result in the issuance of shares of Common Stock in
excess of 9.999% of the then outstanding shares of Common Stock without regard
to any other shares which may be beneficially owned by the Holder or an
affiliate thereof, the Holder shall have the authority and obligation to
determine whether the restriction contained in this Section will limit any
particular exercise hereunder and to the extent that the Holder determines that
the limitation contained in this Section applies, the determination of which
portion of this Warrant is exercisable shall be the responsibility and

                                      -8-
<PAGE>

obligation of the Holder. If the Holder has delivered a Form of Election to
Purchase for a number of Warrant Shares that, without regard to any other shares
that the Holder or its affiliates may beneficially own, would result in the
issuance in excess of the permitted amount hereunder, the Company shall notify
the Holder of this fact and shall honor the exercise for the maximum portion of
this Warrant permitted to be exercised on such Date of Exercise in accordance
with the periods described herein and, at the option of the Holder, either keep
the portion of the Warrant tendered for exercise in excess of the permitted
amount hereunder for future exercises or return such excess portion of the
Warrant to the Holder. The provisions of this Section may be waived by a Holder
(but only as to itself and not to any other Holder) upon not less than 61 days
prior notice to the Company. Other Holders shall be unaffected by any such
waiver.

         11. Fractional Shares. The Company shall not be required to issue or
cause to be issued fractional Warrant Shares on the exercise of this Warrant.
The number of full Warrant Shares which shall be issuable upon the exercise of
this Warrant shall be computed on the basis of the aggregate number of Warrant
Shares purchasable on exercise of this Warrant so presented. If any fraction of
a Warrant Share would, except for the provisions of this Section, be issuable on
the exercise of this Warrant, the Company shall pay an amount in cash equal to
the Exercise Price multiplied by such fraction.

         12. Notices. Any and all notices or other communications or deliveries
hereunder shall be in writing and shall be deemed given and effective on the
earliest of (i) the date of transmission, if such notice or communication is
delivered via facsimile at the facsimile telephone number specified in this
Section prior to 6:30 p.m. (New York City time) on a business day, (ii) the
business day after the date of transmission, if such notice or communication is
delivered via facsimile at the facsimile telephone number specified in this
Section later than 6:30 p.m. (New York City time) on any date and earlier than
11:59 p.m. (New York City time) on such date, (iii) the business day following
the date of mailing, if sent by nationally recognized overnight courier service,
or (iv) upon actual receipt by the party to whom such notice is required to be
given. The addresses for such communications shall be: (i) if to the Company, to
Park Square Building, 31 St. James Avenue, 8th Floor, Boston, MA 02116,
facsimile: 617-422-0675, attention Chief Financial Officer, or (ii) if to the
Holder, to the Holder at the address or facsimile number appearing on the
Warrant Register or such other address or facsimile number as the Holder may
provide to the Company in accordance with this Section.

         13. Warrant Agent. The Company shall serve as warrant agent under this
Warrant. Upon thirty (30) days' notice to the Holder, the Company may appoint a
new warrant agent. Any corporation into which the Company or any new warrant
agent may be merged or any corporation resulting from any consolidation to which
the Company or any new warrant agent shall be a party or any corporation to
which the Company or any new warrant agent transfers substantially all of its
corporate trust or shareholders services business shall be a successor warrant
agent under this Warrant without any further act. Any such successor warrant
agent shall promptly cause notice of its succession as warrant agent to be
mailed (by first class mail, postage prepaid) to the Holder at the Holder's last
address as shown on the Warrant Register.

                                      -9-
<PAGE>

         14. Miscellaneous.

              (a) This Warrant shall be binding on and inure to the benefit of
the parties hereto and their respective successors and assigns. This Warrant may
be amended only in writing signed by the Company and the Holder and their
successors and assigns.

              (b) Subject to Section 14(a), above, nothing in this Warrant shall
be construed to give to any person or corporation other than the Company and the
Holder any legal or equitable right, remedy or cause under this Warrant. This
Warrant shall inure to the sole and exclusive benefit of the Company and the
Holder.

              (c) The corporate laws of the State of Nevada shall govern all
issues concerning the relative rights of the Company and its stockholders. All
other questions concerning the construction, validity, enforcement and
interpretation of this Warrant shall be governed by and construed and enforced
in accordance with the internal laws of the State of New York, without regard to
the principles of conflicts of law thereof. The Company and the Holder hereby
irrevocably submit to the exclusive jurisdiction of the state and federal courts
sitting in the City of New York, borough of Manhattan, for the adjudication of
any dispute hereunder or in connection herewith or with any transaction
contemplated hereby or discussed herein, and hereby irrevocably waives, and
agrees not to assert in any suit, action or proceeding, any claim that it is not
personally subject to the jurisdiction of any such court, or that such suit,
action or proceeding is improper. Each of the Company and the Holder hereby
irrevocably waives personal service of process and consents to process being
served in any such suit, action or proceeding by receiving a copy thereof sent
to the Company at the address in effect for notices to it under this instrument
and agrees that such service shall constitute good and sufficient service of
process and notice thereof. Nothing contained herein shall be deemed to limit in
any way any right to serve process in any manner permitted by law.

              (d) The headings herein are for convenience only, do not
constitute a part of this Warrant and shall not be deemed to limit or affect any
of the provisions hereof.

              (e) In case any one or more of the provisions of this Warrant
shall be invalid or unenforceable in any respect, the validity and
enforceability of the remaining terms and provisions of this Warrant shall not
in any way be affected or impaired thereby and the parties will attempt in good
faith to agree upon a valid and enforceable provision which shall be a
commercially reasonable substitute therefor, and upon so agreeing, shall
incorporate such substitute provision in this Warrant.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK,
                             SIGNATURE PAGE FOLLOWS]

                                      -10-
<PAGE>

                  IN WITNESS WHEREOF, the Company has caused this Warrant to be
duly executed by its authorized officer as of the date first indicated above.

                                              SAFESCIENCE, INC.

                                              By: /s/ Bradley J. Carver
                                                  ------------------------------
                                                  Name: Bradley J. Carver
                                                  Title: President

<PAGE>

                          FORM OF ELECTION TO PURCHASE

(To be executed by the Holder to exercise the right to purchase shares of Common
Stock under the foregoing Warrant)

To SafeScience, Inc.

In accordance with the Warrant enclosed with this Form of Election to Purchase,
the undersigned holder hereby exercises the right to purchase _________________
of the shares of Common Stock ("Warrant Shares") of SafeScience, Inc., a Nevada
corporation (the "Company"), evidenced by the attached Warrant (the "Warrant").
Capitalized terms used herein and not otherwise defined shall have the
respective meanings set forth in the Warrant.

         1.  Payment of Exercise  Price.  The holder  shall pay the sum of
$__________________  to the Company in accordance with the terms of the Warrant.

         2.  Delivery of Warrant  Shares.  The Company  shall deliver to the
holder  __________  Warrant  Shares in accordance with the terms of the Warrant.

Date: _______________ __, ______

   Name of Registered Holder

By:___________________________
     Name:
     Title:

<PAGE>

                  If the number of shares of Common Stock issuable upon this
exercise shall not be all of the shares of Common Stock which the undersigned is
entitled to purchase in accordance with the enclosed Warrant, the undersigned
requests that a New Warrant (as defined in the Warrant) evidencing the right to
purchase the shares of Common Stock not issuable pursuant to the exercise
evidenced hereby be issued in the name of and delivered to:

                                            (Please print name and address)

Dated: _____________, _____                   Name of Holder:

                                              (Print)

                                              (By:)
                                              (Name:)
                                              (Title:)
                                              (Signature  must  conform in all
                                              respects to name of holder as
                                              specified on the face of the
                                              Warrant)

<PAGE>

                               FORM OF ASSIGNMENT

           [To be completed and signed only upon transfer of Warrant]

                  FOR VALUE RECEIVED, the undersigned hereby sells, assigns and
transfers unto ________________________________ the right represented by the
within Warrant to purchase ____________ shares of Common Stock of SafeScience,
Inc. to which the within Warrant relates and appoints ________________ attorney
to transfer said right on the books of SafeScience, Inc. with full power of
substitution in the premises.

Dated:

---------------, ----

                                           -------------------------------------
                                           (Signature  must  conform in all
                                           respects to name of holder as
                                           specified on the face of the Warrant)

                                           -------------------------------------
                                           Address of Transferee

                                           -------------------------------------

                                           -------------------------------------

In the presence of:

--------------------------

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