Document:

Exhibit 4.96

PROMISSORY NOTE 

 

	U.S. $12,000,000.00	Issue Date: October 20, 2017

 

 

Subject to the terms
and conditions of this Note, for value received, AMYRIS, INC., a Delaware corporation (the “Company”),
hereby promises to pay to the order of GINKGO BIOWORKS, INC. or its registered assigns (“Holder”), the
principal sum of Twelve Million Dollars ($12,000,000), or such lesser amount as shall then equal the outstanding principal amount
hereunder, together with interest accrued on the unpaid Principal Amount as set forth more fully in Section 2.1 hereof.

 

The Company and the
Holder are parties to a certain Collaboration Agreement dated as of September 12, 2016 (as amended, the “Collaboration
Agreement”), in furtherance of which the Holder has previously advanced goods and services to the Company in an aggregate
amount of Twelve Million Dollars ($12,000,000) (the “Outstanding Collaboration Amount”), which Outstanding
Collaboration Amount is due and payable to the Holder by the Company as of the date hereof. The Company and the Holder hereby confirm,
acknowledge and agree that (i) the Holder is entitled to repayment of the Outstanding Collaboration Amount and (ii) the Company
shall execute and perform its obligations under this Note in full satisfaction of the Outstanding Collaboration Amount.

 

The following is a
statement of the rights of the Holder and the terms and conditions to which this Note is subject, and to which the Holder hereof,
by the acceptance of this Note, agrees.

 

1.        DEFINITION.
The following definitions shall apply for purposes of this Note.

 

“Affiliate”
has the meaning ascribed to it in Rule 144 promulgated under the Securities

Act.

 

“Applicable
Rate” means a rate equal to the lower of: (a) the Highest Lawful Rate; and (b) ten and one half of one percent (10.5%)
per annum.

 

“Balance”
means, at the applicable time, the sum of the Principal Amount, all then accrued but unpaid interest, the Holder Expenses, and
all other amounts then accrued but unpaid under this Note.

 

“Board
of Directors” means the Company’s Board of Directors.

 

“Business
Day” means a weekday on which banks are open for general banking business in New York City, New York.

 

“Capital
Lease Obligation” means, at the time any determination thereof is to be made, the amount of the liability in respect
of a capital lease that would at such time be required to be capitalized on a balance sheet in accordance with GAAP.

 

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“Change
of Control” shall mean the occurrence of any of the following: (i) the consolidation of the Company with, or the
merger of the Company with or into, another “person” (as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange
Act), or the sale, lease, transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially
all of the assets of the Company and its Subsidiaries taken as a whole, or the consolidation of another “person” with,
or the merger of another “person” into, the Company, other than in each case pursuant to a transaction in which the
“persons” that “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange
Act), directly or indirectly, the Voting Shares of the Company immediately prior to the transaction “beneficially own”,
directly or indirectly, Voting Shares representing at least a majority of the total voting power of all outstanding classes of
voting stock of the surviving or transferee person; (ii) the adoption by the Company of a plan relating to the liquidation or dissolution
of the Company; (iii) the consummation of any transaction (including, without limitation, any merger or consolidation) the result
of which is that any “person” becomes the “beneficial owner” directly or indirectly, of more than 50% of
the Voting Shares of the Company (measured by voting power rather than number of shares); or (iv) the first day on which a majority
of the members of the Board of Directors does not consist of Continuing Directors.

 

“Collaboration
Agreement” is defined in the second introductory paragraph hereto.

 

“Company”
shall mean Amyris, Inc., a Delaware corporation, as set forth in the first introductory paragraph hereto, and any corporation or
other entity which succeeds to the Company’s obligations under this Note, whether by permitted assignment, by merger or consolidation,
operation of law or otherwise.

 

“Continuing
Director” shall mean, as of any date of determination, any member of the Board of Directors who (i) was a member
of the Board of Directors on the Issue Date or (ii) was nominated for election or elected to the Board of Directors with the approval
of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election
and who voted with respect to such nomination or election; provided that a majority of the members of the Board of Directors voting
with respect thereto shall at the time have been Continuing Directors.

 

“Debt”
shall mean, with respect to any Person, any indebtedness of such Person, whether or not contingent, in respect of borrowed money
or evidenced by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements in respect thereof)
or banker’s acceptances or representing Capital Lease Obligations or the balance deferred and unpaid of the purchase price
of any property or representing any Hedging Obligations, except any such balance that constitutes an accrued expense or trade payable,
if and to the extent any of the foregoing indebtedness (other than letters of credit and Hedging Obligations) would appear as a
liability upon a balance sheet of such Person prepared in accordance with GAAP, as well as all Debt of others secured by a Lien
on any asset of such Person (whether or not such Debt is assumed by such Person) and Lease Debt and, to the extent not otherwise
included, the guarantee by such Person of any Debt of any other Person. The amount of any Debt outstanding as of any date shall
be (i) the accreted value thereof, in the case of any Debt that does not require current payments of interest or (ii) the principal
amount thereof, together with any interest thereon that is more than 30 days past due, in the case of any other Debt.

 

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“Default
Rate” means a rate equal to the lower of (a) the Highest Lawful Rate; and (b) fifteen and one half of one percent
(15.5%) per annum.

 

“Event
of Default” has the meaning set forth in Section 6.

 

“Exchange
Act” means the Securities Exchange Act of 1934, as amended from time to time.

 

“Financing
Document” means each of this Note and any other document entered into, executed or delivered under or in connection
with this Note, or for the purpose of amending, modifying, supplementing or restating this Note or any other such documents.

 

“GAAP”
means generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board
of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards
Board or in such other statements by such other entity as have been approved by a significant segment of the accounting profession
in the United States, which are in effect from time to time.

 

“Hedging
Obligations” means, with respect to any Person, the obligations of such Person under (i) currency exchange or interest
rate swap agreements, interest rate cap agreements and interest rate collar agreements and (ii) other agreements or arrangements
designed to protect such Person against fluctuations in interest rates or currency exchange rates.

 

“Highest
Lawful Rate” means the maximum non-usurious rate of interest, as in effect from time to time, which may be charged,
contracted for, reserved, received or collected by Holder in connection with this Note under applicable law.

 

“Holder”
is defined in the first introductory paragraph hereof.

 

“Holder
Expenses” means any documented, out-of-pocket costs, expenses, professional fees (including, without limitation,
attorneys’ fees), and other charges incurred by the Holder in connection with the negotiation, documentation, enforcement
or administration of this Note from time to time.

 

“Issue
Date” is October 20, 2017.

 

“Lease
Debt” means, with respect to any Person, (i) the amount of any accrued and unpaid obligations of such Person arising
under any lease or related document (including a purchase agreement, conditional sale or other title retention agreement) in connection
with the lease of real property or improvement thereon (or any personal property included as part of any such lease) which provides
that such Person is contractually obligated to purchase or cause a third party to purchase the leased property or pay an agreed
upon residual value of the leased property to the lessor (whether or not such lease transaction is characterized as an operating
lease or a capitalized lease in accordance with GAAP) and (ii) the guarantee, direct or indirect, in any manner (including, without
limitation, letters of credit and reimbursement agreements in respect thereof), of any of the amounts set forth in (i) above.

 

“Lien”
means, with respect to any asset, any mortgage, lien, pledge, charge, security

 

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interest or encumbrance of any kind in
respect of such asset, whether or not filed, recorded or otherwise perfected under applicable law (including any conditional sale
or other title retention agreement, any lease in the nature thereof, any option or other agreement to sell or give a security interest
in and any filing of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of
any jurisdiction).

 

“Lost Note
Documentation” means documentation satisfactory to the Company with regard to a lost or stolen Note, including, if
required by the Company, an affidavit of lost note and an indemnification agreement by Holder in favor of the Company with respect
to such lost or stolen Note.

 

“LSA”
means that certain Loan and Security Agreement, dated as of March 29, 2014, as amended, by and between the Company and each of
its subsidiaries party thereto, the other financial institutions or entities from time to time parties thereto (collectively, referred
to as “Lender”) and Stegodon Corporation, a Delaware corporation, as assignee of Hercules Capital, Inc., a Maryland
corporation, in its capacity as administrative agent for itself and the Lender.

 

“Material
Adverse Effect” is defined in Section 5.1.

 

“Maturity
Date” means October 19, 2022.

 

“Note”
means this Promissory Note.

 

“Outstanding
Collaboration Amount” is defined in the second introductory paragraph hereof.

 

“Past Due
Incentive Payments” is defined in Section 7.10.

 

“Person”
means an individual, corporation, limited liability company, partnership, association, joint-stock company, trust, unincorporated
organization, joint venture or other entity or any governmental authority.

 

“Pre-Closing Consents”
is defined in Section 7.3.

 

“Prepayment Date”
is defined in Section 2.1(b)(i).

 

“Prepayment Notice”
is defined in Section 2.1(i).

 

“Principal Amount”
means, at the applicable time, all then outstanding principal of this Note.

 

“Released Parties”
is defined in Section 9 hereof.

 

“SEC” is
defined in Section 7.4.

 

“Securities Act”
means the Securities Act of 1933, as amended from time to time.

 

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“Subsidiary”
means, with respect to any specified Person: (a) any corporation, associationor other business entity of which more than 50% of
the total voting power of shares of capital stock entitled (without regard to the occurrence of any contingency and after giving
effect to any voting entitled (without regard to the occurrence of any contingency and after giving effect to any voting agreement
or stockholders’ agreement that effectively transfers voting power) to vote in the election of directors, managers or trustees
of the corporation, association or other business entity is at the time owned or controlled, directly or indirectly, by that Person
or one or more of the other Subsidiaries of that Person (or a combination thereof); and (b) any partnership (i) the sole general
partner or the managing general partner of which is such Person or a Subsidiary of such Person or (ii) the only general partners
of which are that Person or one or more Subsidiaries of that Person (or any combination thereof).

 

“Partnership
Agreement” means that certain Partnership Agreement by and between the Company and the Holder dated on or about the
date hereof.

 

“Partnership
Agreement Payment” is defined in Section 2.1(d)(i).

 

“The NASDAQ
Stock Market” is defined in Section 7.4.

 

“Voting
Shares” of any Person means capital shares or capital stock of such Person which ordinarily has voting power for
the election of directors (or Persons performing similar functions) of such Person, whether at all times or only so long as no
senior class of securities has such voting power by reason of any contingency.

 

2.        PAYMENT
AT MATURITY DATE; INTEREST. 

 

2.1        Payment.

 

(a)        Principal
Repayment. If this Note has not been previously paid in full pursuant to Section 2.1(d) or Section 2.1(e) hereof, then the
entire Balance shall be due and payable in full in cash on the Maturity Date.

 

(b)        Payment
of Interest. Beginning on November 31, 2017 and continuing on the last day of each month thereafter, through and including
the Maturity Date, the Company shall pay monthly payments of interest in the amount of $105,000 (subject to Section 2.1(c), below),
or such lower amount as represents payment of interest at a fixed per annum rate equal to the Applicable Rate.

 

(c)        Default
Rate of Interest. Immediately upon the occurrence and during the continuance of an Event of Default, the Company shall pay
monthly interest in the amount of $155,000, or such lower amount as represents payment of interest at a fixed per annum rate equal
to the Default Rate. Payment or acceptance of the increased interest rate provided in this Section 2.1(c) is not a permitted alternative
to timely payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or remedies
of the Holder.

 

(d)        Optional
Prepayment. The Company may prepay all (but not less than all) of the entire Balance of this Note at any time, provided that:

 

(i)        The
Company shall have indefeasibly paid in full, in good funds, all of the Partnership Payments (as defined in the Partnership Agreement)
pursuant to the terms and conditions of the Partnership Agreement (the “Partnership Agreement Payment”);

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(ii)        The
Company shall notify the Holder in writing of any prepayment (such notice, a “Prepayment Notice”), not
later than 10:00am New York time, five (5) Business Days prior to the proposed prepayment date (the date on which such prepayment
shall be effective, the “Prepayment Date”). Such Prepayment Notice shall be irrevocable and shall specify
the Prepayment Date and shall include calculations of the Balance to be repaid; and

 

(iii)        The
Holder shall confirm to the Company, in writing, that (i) the Partnership Agreement Payment has occurred and (ii) the calculations
set forth in the Prepayment Notice are accurate and complete.

 

(e)        Mandatory
Prepayment upon a Change of Control. If the Company completes a Change of Control before the payment of the entire Balance of this
Note, then upon the closing of such Change of Control, the Company shall immediately repay the entire Balance of this Note together
with the Partnership Agreement Payment.

 

(f)        Effect
of Payment in Full of the Balance. All rights with respect to this Note shall terminate upon the repayment of the entire Balance
of this Note as provided in this Section 2.1. Notwithstanding the foregoing, Holder agrees to surrender this Note to the Company
(or Lost Note Documentation where applicable) as soon as practicable after repayment pursuant to this Section 2.1.

 

(g)        Savings
Clause. Notwithstanding anything herein to the contrary, if during any period for which interest is computed hereunder, the amount
of interest computed on the basis provided for in this Note, together with all fees, charges and other payments which are treated
as interest under applicable law, as provided for herein or in any other document executed in connection herewith, would exceed
the amount of such interest computed on the basis of the Highest Lawful Rate, then the Company shall not be obligated to pay, and
the Holder shall not be entitled to charge, collect, receive, reserve or take, interest in excess of the Highest Lawful Rate, and
during any such period the interest payable hereunder shall be computed on the basis of the Highest Lawful Rate.

 

3.                 
APPLICATION OF PAYMENTS. All payments will be applied first, to the repayment of accrued fees and expenses
under this Note (including, without limitation, the Holder Expenses); then, to accrued interest until all then outstanding
accrued interest has been paid in full; and then, to the repayment of principal until all principal has been paid in full.
If after all applications of such payments have been made as provided in this Section, then the remaining amount of such payment
that is in either case in excess of the Balance of this Note, shall be returned to the Company.

 

4.                 
EVENTS OF DEFAULT. Each of the following events shall constitute an “Event of Default”
hereunder:

 

(a)        The
Company fails to make any payment when due under this Note on the applicable due date, subject to a ten (10) business day grace
period;

 

(b)
       A receiver is appointed for any material part of the Company’s property,
the Company makes a general assignment for the benefit of creditors, or the Company becomes a debtor or alleged debtor in a
case under the U.S. Bankruptcy Code or becomes the subject of any other bankruptcy or similar proceeding for the general
adjustment of its debts or for its liquidation

 

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(c)       The
Company breaches any material obligation to the Holder under this Note and does not cure such breach within twenty (20) days after
written notice thereof has been given by or on behalf of such Holder to the Company;

 

(d)
       A default under any document evidencing any Debt of the Company in the aggregate principal
amount of at least $2,000,000, or a default under any security agreement, mortgage, indenture, instrument or other document under
which there may be issued or by which there may be secured or evidenced any Debt for money borrowed by the Company (or the payment
of which is guaranteed by the Company) of at least $2,000,000 in the aggregate, whether such Debt or guarantee now exists, or is
created after the Issue Date of this Note, where such default results in the acceleration of amounts due thereunder;

 

(e)
       The Company’s Board of Directors or stockholders adopt a resolution for the liquidation,
dissolution or winding up of the Company;

 

(f)        The
occurrence of a Change of Control;

 

(g)
       The occurrence of a default or an Event of Default (as defined in the Partnership Agreement)
under the Partnership Agreement after the date hereof; or

 

(h)
       The Company shall fail to observe or perform any covenant, condition or agreement contained
in Section 6 hereof.

 

Upon the occurrence
of any Event of Default, all accrued but unpaid expenses, accrued but unpaid interest, all principal and any other amounts outstanding
under this Note shall (i) in the case of any Event of Default under Section 6(b), become immediately due and payable in full without
further notice or demand by Holder and (ii) in the case of any Event of Default other than under Section 6(b), become immediately
due and payable upon written notice by or on behalf of the Holder.

 

5.        REPRESENTATIONS
AND WARRANTIES. The Company represents and warrants to the Holder as follows:

 

 

5.1
       Organization and Standing. The Company is duly incorporated, validly
existing, and in good standing under the laws of the State of Delaware. The Company has all requisite power and authority to
own and operate its properties and assets and to carry on its business as presently conducted and as proposed to be
conducted. The Company is qualified to do business as a foreign entity in every jurisdiction in which the failure to be so
qualified would have, or would reasonably be expected to have, a material adverse effect, individually or in the aggregate,
upon the business, properties, tangible and intangible assets, liabilities, operations, prospects, financial condition or
results of operation of the Company or the ability of the Company to perform its obligations under this Note (a
“Material Adverse Effect”). For the purposes of clarity, the implementation of any plan for the
significant restructuring of the Company, which has been approved by the Board of Directors of the Company as of the date
hereof, shall not constitute a Material Adverse Effect.

 

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5.2        Power.
The Company has all requisite power to execute and deliver this Note, to sell and issue the Note, and to carry out and perform
its obligations under the terms of this Note.

 

5.3        Authorization.
Subject to any waivers of covenants limiting the Company’s ability to incur further debt under outstanding debt instruments
and loans, each of which would be obtained or waived as required prior to the closing (the “Pre-Closing Consents”),
the execution, delivery, and performance of the Note by the Company has been duly authorized by all requisite action on the part
of the Company and its officers, directors and stockholders, and this Note constitutes the legal, valid, and binding obligation
of the Company, enforceable in accordance with its terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization,
moratorium, and other laws of general application affecting enforcement of creditors’ rights generally, and (b) as limited
by laws relating to the availability of specific performance, injunctive relief or other equitable remedies.

 

5.4        Consents
and Approvals. Except for any Current Report on Form 8-K or other document to be filed by the Company with the U.S. Securities
and Exchange Commission (the “SEC”) in connection with the transactions contemplated hereby, the Company
is not required to give any notice to, make any filing with, or obtain any authorization, consent, or approval of any government
or governmental agency in order to consummate the transactions contemplated hereby. No consent, approval, authorization or other
order of, or registration, qualification or filing with, any court, regulatory body, administrative agency, self-regulatory organization,
stock exchange or market (including The NASDAQ Stock Market LLC (“The NASDAQ Stock Market”), or other
governmental body is required for the execution and delivery of the Note, the valid issuance, sale and delivery of the Note to
be sold hereunder other than such as have been made or obtained, or for any securities filings required to be made under federal
or state securities laws applicable to the offering of the Note.

 

5.5        Non-Contravention.
The execution and delivery of this Note and, following satisfaction of the closing conditions set forth in Section 7 hereof, the
issuance, sale and delivery of the Note and the performance by the Company of its obligations under the Note and/or the consummation
of the transactions contemplated thereby, will not (a) conflict with, result in the breach or violation of, or constitute (with
or without the giving of notice or the passage of time or both) a violation of, or default under, (i) subject to obtaining the
Pre-Closing Consents, any bond, debenture, note or other evidence of indebtedness, or under any lease, license, franchise, permit,
indenture, mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which the Company or any
subsidiary is a party or by which it or its properties may be bound or affected, (ii) the Company’s Restated Certificate
of Incorporation, as amended and as in effect on the date hereof, the Company’s Bylaws, as amended and as in effect on the
date hereof, or the equivalent document with respect to any subsidiary, as amended and as in effect on the date hereof, or (iii)
any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental or regulatory body (including
The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to the Company, any of its subsidiaries
or their respective properties, except in the case of clauses (i) and (iii) for such conflicts, breaches, violations or defaults that would not be likely to have,
individually or in the aggregate, a Material Adverse Effect, or (b) result in the creation or imposition of any lien, encumbrance,
claim, security interest or restriction whatsoever upon any of the material properties or assets of the Company or any of its subsidiaries
or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained in any material bond, debenture,
note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any other agreement or instrument
to which the Company or any if its subsidiaries is a party or by which the Company or any of its subsidiaries is bound or to which
any of the property or assets of the Company is subject. For purposes of this Section 5.5, the term “material” shall
apply to agreements, understandings, instruments, contracts or proposed transactions to which the Company is a party or by which
it is bound involving obligations (contingent or otherwise) of, or payments to, the Company in excess of $100,000 in any consecutive
12-month period.

 

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5.6Legal Proceedings.
There is no action, suit or proceeding before any court, governmental agency or body, domestic or foreign, now pending or,
to the knowledge of the Company, threatened against the Company or its subsidiaries wherein an unfavorable decision, ruling or
finding would reasonably be expected to, individually or in the aggregate, (i) materially adversely affect the validity or enforceability
of, or the authority or ability of the Company to perform its obligations under, the Note or (ii) have a Material Adverse Effect.
The Company is not a party to or subject to the provisions of any injunction, judgment, decree or order of any court, regulatory
body, administrative agency or other governmental agency or body that might have, individually or in the aggregate, a Material
Adverse Effect.

 

5.7No Violations.
Neither the Company nor any of its subsidiaries is in violation of its respective certificate of incorporation, bylaws or other
organizational documents, or to its knowledge, is in violation of any statute or law, judgment, decree, rule, regulation, ordinance
or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration
panel or authority applicable to the Company or any of its subsidiaries, which violation, individually or in the aggregate, would
be reasonably likely to have a Material Adverse Effect. Neither the Company nor any of its subsidiaries is in default (and there
exists no condition which, with or without the passage of time or giving of notice or both, would constitute a default) in the
performance of any bond, debenture, note or any other evidence of indebtedness in any indenture, mortgage, deed of trust or any
other material agreement or instrument to which the Company or any of its subsidiaries is a party or by which the Company or any
of its subsidiaries is bound or by which the properties of the Company are bound, which would be reasonably likely to have a Material
Adverse Effect. There has not been, and to the knowledge of the Company, there is not pending or contemplated, any investigation
by the SEC involving the Company or any current or former director or officer of the Company and the Company is not an “ineligible
issuer” pursuant to Rules 164, 405 and 433 under the Securities Act. The Company has not received any comment letter from
the SEC relating to any documents filed by the Company with the SEC which has not been resolved. The SEC has not issued any stop
order or other order suspending the effectiveness of any registration statement filed by the Company under the Exchange Act or
the Securities Act.

 

5.8 Listing
Compliance. The Company is in compliance with the requirements of The NASDAQ Stock Market for continued listing of
the Common Stock thereon and has no knowledge of any facts or circumstances that could reasonably lead to delisting of its Common

 

Stock from The NASDAQ Stock Market. The
Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Stock under
the Exchange Act or the listing of the Common Stock on The NASDAQ Stock Market, nor has the Company received any notification that
the SEC or The NASDAQ Stock Market is contemplating terminating such registration or listing. The transactions contemplated by
the Note will not contravene the rules and regulations of The NASDAQ Stock Market

 

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5.9        Provisions
Relating to Stockholder Rights. This Note does not entitle Holder to any voting rights or other rights as a stockholder
of the Company. No provisions of this Note and no enumeration herein of the rights or privileges of the Holder, shall cause the
Holder to be a stockholder of the Company for any purpose.

 

5.10       Acknowledgement.
The Company acknowledges and agrees that the execution and delivery of this Note to the Holder in satisfaction of the Outstanding
Collaboration Amount does not constitute a waiver of any default or any other rights of the Holder arising under or relating to
the Partnership Agreement.

 

6.        COVENANTS.

 

6.1        Distributions.
The Company shall not, and shall not allow any Subsidiary to, (a) repurchase or redeem any class of stock or other equity interest
other than pursuant to employee, director or consultant repurchase plans or other similar agreements (provided, however, in case
of such permitted repurchases or redemptions, the repurchase or redemption price does not exceed the original consideration paid
for such stock or equity interest); (b) declare or pay any cash dividend or make a cash distribution on any class of stock or other
equity interest, except that a Subsidiary may pay dividends or make distributions to the Company; (c) lend money to any employees,
officers or directors or guarantee the payment of any such loans granted by a third party in excess of $100,000 in the aggregate
(except as may have previously been in effect prior to the Issue Date); or (d) waive, release or forgive any Debt owed by any employees,
officers or directors in excess of $100,000 in the aggregate.

 

6.2        Notification
of an Event of Default. The Company shall notify the Holder immediately of the occurrence of an Event of Default, such
notice to be sent in accordance with Section 10.5 hereof.

 

6.3        Financial
Reporting. The Company’s sole financial reporting obligation shall be to furnish to the Holder written notification
in the event that the consolidated cash balance of the Company is less than $10,000,000 at monthly close.

 

The Company shall not make any change in
its (a) accounting policies or reporting practices, except as required by GAAP or (b) fiscal years or fiscal quarters. The fiscal
year of the Company shall end on December 31. The Holder hereby acknowledges and agrees that the materials described in this Section
6.3 will contain material non-public and confidential information of the Company and its affiliates and the Holder and its respective
affiliates and representatives shall abide by all confidentiality terms applicable under this Note and any confidentiality and
non-disclosure agreements among the parties hereto.

 

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7.        CONDITIONS
PRECEDENT. The Holder’s obligation to accept delivery of this Note at the closing in satisfaction of the Outstanding
Collaboration Amount shall be subject to the satisfaction of all the conditions precedent set forth below:

 

7.1        Good
Standing. The Company shall be validly existing as a corporation in good standing under the laws of Delaware as evidenced
by a certificate of the Secretary of State of the State of Delaware, a copy of which shall be provided to the Holder at the closing.

 

7.2        Board
Approval. The terms and conditions of the issuance of the Note and all other documents related hereto shall have been duly
approved by the Board of Directors of the Company (including the audit committee and at least six directors who are disinterested
with respect to the transactions contemplated hereby).

 

7.3        Other
Approvals. The Company shall have obtained all governmental, regulatory or third party consents and approvals required
in connection with the transactions contemplated hereby, if any, including, without limitation, obtaining any waivers of any other
negative covenants and pro rata or similar preemptive rights that may apply to the issuance of the Note.

 

7.4        Execution
of Partnership Agreement. The Holder shall have received, in form and substance satisfactory to the Holder, a fully-executed
copy of the Partnership Agreement.

 

8.        RIGHT
OF SETOFF. If an Event of Default shall have occurred and be continuing or if the Holder shall have been served with a
trustee process or similar attachment relating to property of the Company, the Holder is hereby authorized at any time and from
time to time, to the fullest extent permitted by applicable law, to set off and apply any and all deposits of any type or nature,
and any other amounts delivered to the Holder by or at the direction of the Company, in whatever currency, and/or any and all amounts
owed by the Holder to or for the account of the Company (whether arising under this Agreement or otherwise, in whatever currency)
against any and all other obligations now or hereafter existing under this Note, any other Financing Document, or any other agreement
between the Holder and the Company, and irrespective of whether or not the Holder shall have made any demand under this Note, any
other Financing Document, the Partnership Agreement, or any other agreement, and although such obligations of the Company may be
contingent or unmatured. The rights of the Holder under this Section 8 are in addition to other rights and remedies (including
other rights of setoff) that the Holder may have. The Holder agrees to notify the Company promptly after any such setoff and application,
provided that the failure to give such notice shall not affect the validity of such setoff and application.

 

    11 /15

     

    

9.       NO
DEFENSES.

 

9.1        The
Company hereby acknowledges and agrees that, as of the date hereof (except as provided below in Section 9.2): (a) it does not have
any claim or cause of action related to any agreement between or among the Company and the Holder against the Holder (or any of
their respective directors, officers, employees, agents, subsidiaries, affiliates, attorneys, attorneys’ consultants, predecessors,
successors or assigns), including, without limitation, the Collaboration Agreement; (b) it does not have any offset right, counterclaim,
or defense of any kind against the

 

 

obligations under the Collaboration Agreement
or any other agreement between the Holder and the Company or any portion thereof; and (c) the Holder has heretofore properly performed
and satisfied in a timely manner all of its obligations and commitments to the Company, including, without limitation, with respect
to the Collaboration Agreement. For and in consideration of the agreements contained in this Note and other good and valuable consideration,
and except as provided below in Section 9.2, the Company unconditionally and irrevocably releases, waives, and forever discharges
the Holder, together with its respective predecessors, successors, assigns, subsidiaries, affiliates, agents, employees, directors,
officers, attorneys and attorneys’ consultants (collectively, the “Released Parties”), from the following, in
each case only as related to the Collaboration Agreement and any other agreement between the Company and the Holder: (x) any and
all liabilities, obligations, duties, promises, or indebtedness of any kind (if any) of the Released Parties to the Company or
any of its affiliates, which existed, arose, or occurred at any time from the beginning of the world to the date of this Note,
and (y) all claims, offsets, causes of action, suits, or defenses of any kind whatsoever (if any), which the Company or any of
its affiliates might otherwise have against the Released Parties, or any of them, in either case (x) or (y) on account of any condition,
act, omission, event, contract, liability, obligation, indebtedness, claim, cause of action, defense, circumstance, or matter of
any kind, which existed, arose, or occurred at any time from the beginning of the world to the date of this Note, whether at law
or in equity, whether based upon statute, common law or otherwise, whether matured, contingent or non-contingent, whether direct
or indirect, whether known or unknown, whether suspected or unsuspected, which the Company ever had, now has, or may claim to have
against, arising out of, based on, asserted in, or in connection with any agreement or event including, without limitation, the
Collaboration Agreement or any other agreement between the Holder and the Company or any portion thereof.

 

10.        GENERAL
PROVISIONS.

 

10.1        Waivers.
The Company and all endorsers of this Note hereby waive notice, presentment, protest and notice of dishonor.

 

10.2        Transfer.
Neither this Note nor any rights hereunder may be assigned, conveyed or transferred, in whole or in part, without the Company’s
prior written consent, which the Company may withhold in its sole discretion; provided, however, that this
Note may be assigned, conveyed or transferred without the prior written consent of the Company to any Affiliate of the Holder who
(a) executes and delivers an acknowledgement that such transferee agrees to be subject to, and bound by, all the terms and conditions
of this Note, (b) makes the representations and warranties to the Company that are set forth in Section 5 of this Note, and (c)
(if requested by the Company) delivers to the Company an opinion of legal counsel, reasonably satisfactory to the Company, that
such transfer complies with state and federal securities laws. Subject to the foregoing, the rights and obligations of the Company
and Holder under this Note shall be binding upon and benefit their respective permitted successors, assigns, heirs, administrators
and transferees.

 

10.3        Governing
Law. This Note shall be governed, construed and interpreted in accordance with the laws of the State of New York, without
giving effect to principles of conflicts of law.

 

    12 /15

     

    

 

10.4        Headings.
The headings and captions used in this Note are used only for convenience and are not to be considered in construing or interpreting
this Note. All references in this Note to sections and exhibits shall, unless otherwise provided, refer to sections hereof and
exhibits attached hereto, all of which exhibits are incorporated herein by this reference.

 

10.5        Notices.
All notices, requests, and other communications hereunder shall be in writing and will be deemed to have been duly given and received
(a) when personally delivered, (b) when sent by facsimile upon confirmation of receipt, (c) one business day after the day on which
the same has been delivered prepaid to a nationally recognized courier service, or

(d) five business days after the deposit
in the United States mail, registered or certified, return receipt requested, postage prepaid, in each case addressed,

 

If to the Company:

 

Amyris, Inc.

5885 Hollis Street, Suite 100

Emeryville, CA 94608

Attn: General Counsel

Facsimile number:

 

If to the Holder:

Ginkgo Bioworks, Inc.

27 Drydock Ave., Floor 8

Boston, MA 02210

Attn:

 

with a copy (which shall not constitute notice)
to:

 

Choate, Hall & Stewart LLP

2 International Place

Boston, MA 02110

Attn:

Fascimile number:

 

or as otherwise indicated by Holder by
providing notice of a change in its address, facsimile number, or other information to the Company. The Holder and the Company
may each agree in writing to accept notices and other communications to it hereunder by electronic communications pursuant to procedures
reasonably approved by it; provided that approval of such procedures may be limited to particular notices or communications.

 

10.6        Place
of Payment. Payments made hereunder shall be delivered to the Holder at the address set forth below:

 

Ginkgo Bioworks, Inc.

27 Drydock Ave., Floor 8

Boston, MA 02210

Attn:

 

or at such other address or the attention
of such other Person as specified by prior written notice to the Company, including any transferee of this Note.

 

    13 /15

     

    

10.7        Amendments
and Waivers. This Note may be amended and provisions may be waived only by written agreement of the Company and the Holder.
Any amendment or waiver effected in accordance with this Section 10.7 shall be binding upon each holder of the Note, each future
holder of the Note, and the Company.

 

10.8        Severability.
If one or more provisions of this Note are held to be unenforceable under applicable law, then such provision(s) shall be excluded
from this Note to the extent they are held to be unenforceable and the remainder of the Note shall be interpreted as if such provision(s)
were so excluded and shall be enforceable in accordance with its terms.

 

[Signature page follows.]

 

    14 /15

     

    

 

IN WITNESS WHEREOF,
the Company has caused this Promissory Note to be signed in its name as of the date first written above.

 

 

THE COMPANY

 

AMYRIS, INC.

 

 

 

By: /s/ John Melo

 

Name:John Mel

 

Title: CEO

 

15 /15Exhibit 4.97

AMYRIS, INC.

 

NOTE

 

No. B-1$25,000,000.00

 

Amyris, Inc., a Delaware corporation (the
“Company”), for value received, hereby promises to pay to DSM FINANCE BV, or registered assigns (“Holder”),
the principal sum of hereof, which shall be Twenty-Five Million Dollars ($25,000,000.00), no later than December 31, 2021 and to
pay interest thereon, from the date of this Note, or from the most recent interest payment date to which interest has been paid
on this Note, quarterly on March 31, June 30, September 30 and December 31 in each year, commencing December 31, 2017, at the rate
of 2.5% per quarter (calculated on a simple interest basis and paid in cash) until the principal hereof is due and in the manner
set forth below.

 

Payment of the principal of this Note shall
be made upon the surrender of this Note to the Company, at its chief executive office (or such other office within the United States
as shall be designated by the Company to the holder hereof) (the “Designated Office”), in such coin or currency
of the United States of America as at the time of payment shall be legal tender for the payment of public and private debts. Payment
of interest in cash and all other amounts payable in cash with respect to this Note shall be made by wire transfer to the holder,
provided that if the holder shall not have furnished wire instructions in writing to the Company no later than the Business
Day immediately prior to the date on which the Company makes such payment, such payment may be made by U.S. dollar check mailed
to the address of the Person entitled thereto as such address shall appear in the Company security register.

 

Capitalized terms used and not otherwise
defined herein shall have the respective meanings given to those terms in Section 4 hereof.

 

1.       Redemption.
This Note is subject to redemption, as a whole or from time to time in part (in any amount that is an integral multiple of $1,000),
upon not less than five (5) days’ prior written notice in the manner provided in Section 5(b) hereof, at the election of
the Company, at a redemption price of 100% of the principal amount hereof, together with accrued interest to the redemption date,
but interest installments whose stated maturity is on or prior to such redemption date will be payable to the holder of this Note,
or one or more predecessor securities, of record at the close of business on the relevant record dates referred to on the face
hereof.

 

2.       Certain
Covenants. Until the Obligations hereunder are paid in full:

 

		(a)	The Company will maintain or cause to be maintained its and each of its Subsidiaries’ corporate or other organizational
existence and good standing in its jurisdiction of incorporation and maintain its qualification in each jurisdiction where the
failure to so qualify would reasonably be expected to have a Material Adverse Effect.

 

		(b)	The Company will, and will cause each of its Subsidiaries to, comply with all applicable statutes, regulation and orders
                                                                 of, and all applicable restrictions imposed by, all governmental bodies, domestic or foreign, in respect of the conduct of its business and the ownership
of its property, other than those the noncompliance with which would not have, and which would not reasonably be expected to have,
a Material Adverse Effect.

 

     

     

    

 

The Company will pay and discharge, and will cause each
of its Subsidiaries to pay and discharge, all taxes, assessments and governmental charges or levies imposed upon it or upon its
income or profits, or upon any properties belonging to it and all lawful claims which, if unpaid, might become a Lien upon any
properties of the Company or any of its Subsidiaries; provided that, neither the Company nor any of its Subsidiaries shall
be required to pay any such tax, assessment, charge, levy or claim which is being contested in good faith and by proper proceedings
if it has maintained adequate reserves with respect thereto in accordance with GAAP.

 

		(c)	The Company will, and will cause each of its Subsidiaries to, (A) maintain insurance coverage by such insurers and in such
forms and amounts and against such risks as are customarily carried by persons conducting businesses similar to those of the Company
and its Subsidiaries and (B) promptly upon the holder’s request, furnish to the holder such information about such insurance
as the holder may from time to time reasonably request, which information shall be prepared in form and detail satisfactory to
the holder.

 

		(d)	The Company shall notify Holder promptly following the date on which an executive officer of the Company has concluded that
an event has occurred that has caused or would reasonably be expected to cause a Material Adverse Effect.

 

		(d)	Neither the Company nor any of its Subsidiaries shall (i) pay any dividends or make any distributions on its Equity Securities
other than dividends paid on the common stock of the Company paid solely in common stock of the Company; (ii) purchase, redeem,
retire, defease or otherwise acquire for value any of its Equity Securities; (iii) return any capital to any holder of its Equity
Securities; (iv) make any distribution of assets, Equity Securities, obligations or securities to any holder of its Equity Securities;
or (v) set apart any sum for any such purpose; provided that any Subsidiary may pay cash dividends to the Company.

 

		(e)	Neither the Company nor any of its Subsidiaries shall make any payment or distribution in cash to any stockholder or Affiliate
of the Company other than payments or distributions made in the ordinary course of business.

 

3.       Events
of Default.

 

		(a)	“Event of Default”, wherever used herein, means any one of the following events (whatever the reason for
such Event of Default and whether it shall be voluntary or involuntary or be effected by operation of law or pursuant to any judgment,
decree or order of any court or any order, rule or regulation of any administrative or governmental body):

 

    2 

     

    

 

		(i)	default in the payment of any principal upon this Note when it becomes due and payable, following a ten (10) day cure period;
or

 

		(ii)	default in the payment of any interest upon this Note when it becomes due and payable, following a cure period of ten (10)
days after written notice to the Company in the manner set forth in Section 5(b);

 

		(iii)	default in the performance, or breach, of any covenant of the Company herein (other than any default, or breach, which is specifically
dealt with in clauses (i) or (ii) of Section 3(a)) and continuance of such default or breach for a period of forty-five (45) days
after the earlier to occur of (A) the date on which an executive officer of the Company becomes aware of such default or breach
and (B) the date on which the holder of this Note has provided written notice to the Company in the manner set forth in Section
5(b) specifying such default or breach and requiring it to be remedied and stating that such notice is a “Notice of Default”
hereunder;

 

		(iv)	the entry by a court having jurisdiction in the premises of (x) a decree or order for relief in respect of the Company or any
Significant Subsidiary (as defined below) in an involuntary case or proceeding under any applicable Federal or state bankruptcy,
insolvency, reorganization or other similar law or (y) a decree or order approving as properly filed a petition seeking reorganization,
arrangement, adjustment or composition of or in respect of the Company or any Significant Subsidiary under any applicable Federal
or state law, or appointing a custodian, receiver, liquidator, assignee, trustee, sequestrator or other similar official of the
Company or any Significant Subsidiary or of any substantial part of its or their respective property, or ordering the winding up
or liquidation of its affairs, and the continuance of any such decree or order for relief or any such other decree or order unstayed
and in effect for a period of sixty (60) consecutive days;

 

		(v)	the commencement by the Company or any Significant Subsidiary of a voluntary case or proceeding under any applicable Federal
or state bankruptcy, insolvency, reorganization or other similar law or of any other case or proceeding to be adjudicated a bankrupt
or insolvent, or the consent by the Company or any Significant Subsidiary to the entry of a decree or order for relief in respect
of the Company or any Significant Subsidiary in an involuntary case or proceeding under any applicable Federal or state bankruptcy,
insolvency, reorganization or other similar law or to the commencement of any bankruptcy or insolvency case or proceeding against
either the Company or a Significant Subsidiary, or the filing by either the Company or a Significant Subsidiary of a petition or
answer or consent seeking reorganization or similar relief under any applicable Federal or state law, or the consent by it to the
filing of such petition or to the appointment of or taking possession by a custodian, receiver, liquidator, assignee, trustee,
sequestrator or other similar official of the Company or any Significant
Subsidiary or of any substantial part of the property of either the Company or any Significant Subsidiary, or the making by either
the Company or any Significant Subsidiary of an assignment for the benefit of creditors, or the admission by either the Company
or any Significant Subsidiary in writing of its inability to pay its debts generally as they become due, or the taking of corporate
action by the Company or any Significant Subsidiary in furtherance of any such action;

 

 

    3 

     

    

		(vi)	any representation, warranty or certification by or on behalf of the Company or any of its Subsidiaries made or deemed made
herein or in the Credit Agreement (other than the representations and warranties set forth in clause (ii) of Section 2(g) of the
Credit Agreement) shall prove to have been incorrect in any material respect (without duplication of other materiality qualifiers
contained therein) on or as of the date made or deemed made;

 

		(vii)	the Company or any of its Subsidiaries (i) fails to make any payment in respect of any indebtedness (other than indebtedness
owing to the holder of this Note pursuant to this Note and the Credit Agreement) having an aggregate principal amount of more than
$10.0 million when due (whether by scheduled maturity, required prepayment, acceleration, demand, or otherwise) and such failure
continues after the applicable grace or notice period, if any, specified in the document relating thereto on the date of such failure;
or (ii) fails to perform or observe any other condition or covenant, or any other event shall occur or condition exist, under any
agreement or instrument relating to any such indebtedness, if the effect of such failure, event or condition is to cause such indebtedness
to be declared to be due and payable (or otherwise required immediately to be prepaid, redeemed, purchased or defeased) prior to
its stated maturity (without regard to any subordination terms with respect thereto) or cash collateral in respect thereof to be
demanded;

 

		(viii)	one or more monetary or non-monetary judgments, orders or decrees shall be rendered against any one or more of the Company
and its Subsidiaries which has, either individually or in the aggregate, a Material Adverse Effect, and there shall be any period
of thirty (30) consecutive days during which a stay of enforcement of such judgment or order, by reason of a pending appeal or
otherwise, shall not be in effect;

 

		(ix)	a Change of Control occurs;

 

		(x)	the Company has materially breached any provision of that certain Farnese License Agreement, dated as of November 14, 2017,
by and between the Company and DSM Nutritional Products Ltd., and such breach has not been cured within sixty (60) days after such
breach; or

 

    4 

     

    

 

		(xi)	any material provision of this Note or the Credit Agreement shall for any reason cease to be valid and binding on or enforceable
against the Company or the Company shall so state in writing or bring an action to limit its obligations or liabilities under this
Note or the Credit Agreement.

 

		(b)	The Company will give the holder of this Note notice, within two (2) Business Days of the occurrence thereof, of any Event
of Default or any event that, with the giving of notice or passage of time or both, would become an Event of Default. Such notice
shall be given in the manner provided in Section 5(b).

 

		(c)	During the continuance of an Event of Default, the Company shall provide the holder of this Note within three (3) Business
Days such information as the holder of this Note may reasonably request to establish any assertion by the Company under this Section
3.

 

		(d)	Upon the occurrence and during the continuance of a General Event of Default or a Payment Event
of Default, the holder of this Note may declare all or any portion of the unpaid principal amount of this Note, all interest then
accrued and unpaid thereon, and all other amounts then owing or payable hereunder or under the Credit Agreement to be immediately
due and payable; without presentment, demand, protest or other notice of any kind, all of which are hereby expressly waived by
the Company (an “Acceleration”).

 

		(e)	Upon the occurrence of a Bankruptcy Event of Default, the unpaid principal amount under this Note and all interest and other
amounts owing under this Note shall automatically become due and payable without further act of the holder of this Note.

 

		(f)	The holder of the Note is hereby authorized, at any time and from time to time during the continuance of any Event of Default
and to the fullest extent permitted by applicable law, to set off and apply any and all indebtedness, claims or other obligations
at any time owing by the holder of the Note or any of its Affiliates (including, without limitation, amounts owing under the Ancillary
Agreements (as defined in the Quota Purchase Agreement) to or for the credit or the account of the Company against any payment
obligation of the Company (including, without limitation, payments of principal and interest) now or hereafter existing. Upon each
exercise of the setoff right described in the preceding sentence, the holder of the Note agrees promptly to notify the Company;
provided, however, that the failure to give such notice shall not affect the validity of such setoff and application. The rights
under this Section 3(f) are in addition to any other rights and remedies that the holder of the Note may have.

 

4.       Definitions.
Capitalized terms used in this Note and not otherwise defined have the meanings given to them in the Credit Agreement. Unless otherwise
defined in this Note, the following capitalized terms shall have the following respective meanings when used herein:

 

 

    5 

     

    

“Affiliate” of any specified
Person means any other Person directly or indirectly controlling or controlled by or under direct or indirect common control with
such specified Person. For the purposes of this definition, “control”, when used with respect to any specified Person,
means the power to direct the management and policies of such Person, directly or indirectly, whether through the ownership of
voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings
correlative to the foregoing.

 

“Bankruptcy Event of Default”
means an Event of Default specified in Section 3(a)(iv) or 3(a)(v).

 

“Business
Day” means any day other than Saturday or Sunday on which commercial banks are open for business in New York, New York.

 

“Change of Control” means
any (i) reorganization, recapitalization, consolidation or merger (or similar transaction or series of related transactions) involving
the Company, sale or exchange of outstanding (or issuance of new) shares of capital stock (or similar transaction or series of
related transactions) of the Company in which the holders of the Company’s outstanding shares of
capital stock immediately before consummation of such transaction or series of related transactions do not, immediately
after consummation of such transaction or series of related transactions, retain shares of capital stock representing more than
fifty percent (50%) of the voting power of the surviving entity of such transaction or series of related transactions (or the parent
of such surviving entity if such surviving entity is wholly owned by such parent), in each case without regard to whether the
Company is the surviving entity, or (ii) sale or issuance by the Company of new shares of preferred stock
of the Company to investors, none of whom are current investors in the Company, and
such new shares of preferred stock are senior to all existing preferred
stock and common stock
with respect to liquidation preferences, and the aggregate liquidation preference of the new shares of preferred stock
is more than fifty percent (50%) of the aggregate liquidation preference of all shares of preferred stock
of the Company.

 

“Credit Agreement” means
the Credit Agreement, dated as of December 28, 2017, entered into by and between the Company and the Lender.

 

“Equity Securities” of
any Person means (a) all common stock, preferred stock, participations, shares, partnership interests or other equity interests
in and of such Person (regardless of how designated and whether or not voting or non-voting) and (b) all warrants, options and
other rights to acquire any of the foregoing.

 

“GAAP” means generally
accepted accounting principles as in effect in the United States of America from time to time.

 

“General Event of Default”
means an Event of Default that is neither a Payment Event of Default nor a Bankruptcy Event of Default.

 

“Payment Event of Default”
means an Event of Default specified in Section 3(a)(i) or 3(a)(ii).

 

 

    6 

     

    

“Person” shall mean and
include an individual, a partnership, a corporation (including a business trust), a joint stock company, a limited liability company,
an unincorporated association, a joint venture or other entity or a governmental authority.

 

“Significant Subsidiary”
means, with respect to any Person, a Subsidiary of such Person that would constitute a significant subsidiary as such term is defined
under Rule 1-02 of Regulation S-X of the Commission.

 

“Subsidiary” shall mean
(a) any corporation of which more than fifty percent (50%) of the issued and outstanding equity securities having ordinary voting
power to elect a majority of the board of directors of such corporation is at the time directly or indirectly owned or controlled
by the Company, (b) any partnership, joint venture, limited liability company or other association of which more than fifty percent
(50%) of the equity interests having the power to vote, direct or control the management of such partnership, joint venture, limited
liability company or other association is at the time directly or indirectly owned and controlled by the Company, and (c) any other
entity included in the financial statements of the Company on a consolidated basis.

 

5.       Other.

 

		(a)	No provision of this Note shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay
the principal of and interest, if any, on this Note at the times, places and rate, and in the coin or currency, herein prescribed
or to repay this Note as herein provided.

 

		(b)	The Company will give prompt written notice to the holder of this Note of any change in the location of the Designated Office.
Any notice to the Company or to the holder of this Note shall be given in the manner set forth in the Credit Agreement.

 

		(c)	The transfer of this Note is registrable on the register maintained by the Company upon surrender of this Note for registration
of transfer at the Designated Office, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory
to the Company duly executed by, the holder hereof or such holder’s attorney duly authorized in writing, and thereupon one
or more new securities, of authorized denominations and for the same aggregate principal amount, will be issued to the designated
transferee or transferees. Such securities are issuable only in registered form without coupons in denominations of $1,000 and
any integral multiple thereof. No service charge shall be made for any such registration of transfer, but the Company may require
payment of a sum sufficient to recover any tax or other governmental charge payable in connection therewith. Prior to due presentation
of this Note for registration of transfer, the Company and any agent of the Company may treat the Person in whose name this Note
is registered as the owner thereof for all purposes, whether or not this Note be overdue, and neither the Company nor any such
agent shall be affected by notice to the contrary.

 

    7 

     

    

 

		(d)	This Note shall be governed by and construed in accordance with the internal laws of the State of New York, without regard
to principles of conflicts of laws.

 

[The remainder of this page is intentionally
left blank]

    8 

     

    

 

IN WITNESS WHEREOF, the Company has caused
this Note to be duly executed.

 

Dated: December 28, 2017

 

Amyris, Inc.

 

By: /s/ John Melo

Name:John Melo

Title:President and Chief Executive Officer

 

 

 

[Note Signature Page]

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