Document:

FOURTH AMENDMENT TO

LOAN AND SECURITY AGREEMENT

(TERM LOAN AND REVOLVING LOAN)

 

This FOURTH AMENDMENT
TO LOAN AND SECURITY AGREEMENT (this “Amendment”), dated as of March 3, 2014 (the “Effective Date”),
is entered into by and among THIRD SECURITY SENIOR STAFF 2008 LLC, as administrative agent (the “Agent”),
and a lender, the other lenders party hereto (collectively, the “Lenders”), and TRANSGENOMIC, INC., a
Delaware corporation (the “Borrower”).

 

WHEREAS, the
Borrower, the Agent and the Lenders are parties to that certain Loan and Security Agreement (Term Loan and Revolving Loan), dated
as of March 13, 2013 (as amended, restated, supplemented, or otherwise modified from time to time, the “Loan Agreement”),
whereby the Lenders have extended to the Borrower a loan facility pursuant to the Loan Agreement on the terms and subject to the
conditions contained therein; and

 

WHEREAS, the
Borrower has requested that the Agent and the Lenders, and the Agent and the Lenders have agreed to, subject to the terms and conditions
set forth in this Amendment, amend certain provisions of the Loan Agreement effective as of the Effective Date.

 

NOW, THEREFORE,
in consideration of the foregoing premises, and other good and valuable consideration, the receipt and legal sufficiency of which
are hereby acknowledged, the parties hereto hereby agree as follows:

 

1.Definitions.
Unless otherwise defined herein, capitalized terms used herein shall have the meanings assigned to them in the Loan Agreement.

 

2.Amendment
to the Loan Agreement. Effective as of the Effective Date, the Loan Agreement is amended as follows:

 

(a)Section
2.2(b) of the Loan Agreement is amended by amending and restating the first sentence thereof as follows:

 

“Commencing
on the Amortization Date and continuing on the Payment Date of each successive month thereafter through and including the Maturity
Date, Borrower shall make monthly payments of interest to each Lender in accordance with its respective Pro Rata Share, in arrears,
and calculated as set forth in Section 2.3.”

 

(b)The
Loan Agreement is amended by inserting the following text as a new Section 2.8(d):

 

“(d)Payment and Computation of Interest. Interest on the Advances is payable on each
Payment Date and shall be computed on the basis of a 360-day year for the actual number of days elapsed in the period during which
such interest accrues. In computing interest on the Revolving Line, the date of the making of any Credit Extension shall be included
and the date of payment shall be excluded; provided, however, that if any Credit Extension is repaid on the same
day on which it is made, such day shall be included in computing interest on such Credit Extension.”

 

    	 

    	 

    

 

(c)Section
14.1 of the Loan Agreement is amended by amending and restating the definition of “Amortization Date” as follows:

 

“Amortization
Date” means April 1, 2015.

 

3.Conditions
Precedent. The effectiveness of this Amendment is subject to the satisfaction of the following conditions precedent:

 

(a)receipt
by the Agent of a copy of this Amendment, duly executed and delivered by the Borrower and the Required Lenders;

 

(b)receipt
by the Agent of any other documents or agreements reasonably requested by the Agent in connection with the transactions contemplated
by this Amendment;

 

(c)the
truth and accuracy of the representations and warranties contained in Section 5 of this Amendment; and

 

(d)receipt
by the Lenders and the Agent of any fees and expenses due and payable on or before the Effective Date under the Loan Agreement
or this Amendment.

 

4.Reaffirmation.
The Borrower hereby reaffirms each of the agreements, covenants, and undertakings set forth in the Loan Agreement and each and
every other Loan Document as of the Effective Date as if the Borrower was making said agreements, covenants and undertakings as
of the Effective Date.

 

5.Representations,
Warranties, Covenants and Acknowledgments. To induce the Agent and Lenders to enter into this Amendment, the Borrower hereby:

 

(a)represents
and warrants that (i) as of the Effective Date, all of the representations and warranties made or deemed to be made under the Loan
Documents are true and correct in all material respects (other than any representation or warranty that is qualified by materiality
or Material Adverse Effect, in which case such representation or warranty is true and correct in all respects) on and as of the
Effective Date to the same extent as though made on and as of the Effective Date, except to the extent such representations and
warranties specifically relate to an earlier date, in which case such representations and warranties were true and correct in all
material respects (other than any representation or warranty that is qualified by materiality or Material Adverse Effect, in which
case such representation or warranty was true and correct in all respects) on and as of such earlier date; (ii) as of the Effective
Date, there exists no Default or Event of Default under the Loan Agreement or any of the other Loan Documents; (iii) the Borrower
has the corporate power and is duly authorized to enter into, deliver and perform this Amendment; and (iv) this Amendment is the
legal, valid and binding obligation of the Borrower enforceable against the Borrower in accordance with its terms, except as may
be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws relating to or limiting creditors’ rights
generally or by equitable principles relating to enforceability;

 

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(b)acknowledges
and agrees that (i) this Amendment does not and shall not create (nor shall the Borrower or any of its Subsidiaries rely upon the
existence of or claim or assert that there exists) any obligation of the Agent or any Lender to consider or agree to any further
consent, waiver or amendment with respect to any Loan Document and, in the event that the Agent or any Lender subsequently agrees
to consider any further consent, waiver or amendment with respect to any Loan Document, neither this Amendment nor any other conduct
of the Agent or any Lender shall be of any force or effect on the Agent’s or such Lender’s consideration or decision
with respect thereto, and neither the Agent nor any Lender shall have any further obligation whatsoever to consider or agree to
any further consent, waiver or amendment with respect to any Loan Document; and (ii) the Agent and each Lender reserves all of
their respective rights pursuant to the Loan Agreement and all other Loan Documents;

 

(c)further
acknowledges and agrees that the Agent’s and Lenders’ agreement to amend the specific matters addressed in this Amendment,
do not and shall not create (nor shall the Borrower or any of its Subsidiaries rely upon the existence of or claim or assert that
there exists) any obligation of the Agent or any Lender to consider or agree to any further waivers, consents or amendments and,
in the event that the Agent or any Lender subsequently agrees to consider any further waivers, consents or amendments, neither
this Amendment nor any other conduct of the Agent or any Lender shall be of any force or effect on the Agent’s or any Lender’s
consideration or decision with respect to any such requested consent;

 

(d)further
acknowledges and agrees that no right of offset, defense, counterclaim, claim, cause of action or objection in favor of the Borrower
against any Lender exists arising out of or with respect to (i) this Amendment, the Loan Agreement or any other Loan Document,
or (ii) any other documents now or heretofore evidencing, securing or in any way relating to the foregoing; and

 

(e)further
acknowledges and agrees that this Amendment shall be deemed a Loan Document for all purposes under the Loan Agreement and the other
Loan Documents.

 

6.Effect of
Non-Compliance. To the extent any representation or warranty made herein shall be untrue in any material respect, such occurrence
shall be deemed an Event of Default pursuant to the terms of the Loan Agreement and the other Loan Documents.

 

7.Release; Indemnitees.

 

(a)In
further consideration of the execution of this Amendment by the Agent and each Lender, the Borrower, individually and on behalf
of its successors (including, without limitation, any trustees acting on behalf of the Borrower and any debtor-in-possession with
respect to the Borrower), assigns, subsidiaries and Affiliates, hereby forever releases the Agent, each Lender and their respective
successors, assigns, parents, subsidiaries, Affiliates, officers, employees, directors, agents and attorneys (collectively, the
“Releasees”) from any and all debts, claims, demands, liabilities, responsibilities, disputes, causes, damages,
actions and causes of actions (whether at law or in equity) and obligations of every nature whatsoever, whether liquidated or unliquidated,
whether known or unknown, matured or unmatured, fixed or contingent (collectively, “Claims”) that the Borrower
may have against the Releasees which arise from or relate to any actions which the Releasees may have taken or omitted to take
in connection with the Loan Agreement or the other Loan Documents prior to the Effective Date, including, without limitation, with
respect to the Obligations, any Collateral, the Loan Agreement, any other Loan Document and any third parties liable in whole or
in part for the Obligations. This provision shall survive and continue in full force and effect whether or not the Borrower shall
satisfy all other provisions of this Amendment, the Loan Documents or the Loan Agreement, including payment in full of all Obligations.

 

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(b)The
Borrower hereby further agrees to indemnify and hold the Releasees harmless with respect to any and all liabilities, obligations,
losses, penalties, actions, judgments, suits, costs, expenses or disbursements of any kind or nature whatsoever incurred by the
Releasees, or any of them, whether direct, indirect or consequential, as a result of or arising from or relating to any proceeding
by, or on behalf of any Person, including, without limitation, officers, directors, agents, trustees, creditors, partners or shareholders
of the Borrower or any parent, Subsidiary or Affiliate of the Borrower, whether threatened or initiated, asserting any claim for
legal or equitable remedy under any statutes, regulation or common law principle arising from or in connection with the negotiation,
preparation, execution, delivery, performance, administration and enforcement of this Amendment. The foregoing indemnity shall
survive the payment in full of the Obligations and the termination of this Amendment, the Loan Agreement and the other Loan Documents.

 

8.Effect; Relationship
of Parties. Except as expressly modified hereby, the Loan Agreement and each other Loan Document shall be and remain in full
force and effect as originally written, and shall constitute the legal, valid, binding and enforceable obligations of the Borrower
to the Agent and Lenders. The relationship of the Agent and Lenders, on the one hand, and the Borrower, on the other hand, has
been and shall continue to be, at all times, that of creditor and debtor and not as joint venturers or partners. Nothing contained
in this Amendment, any instrument, document or agreement delivered in connection herewith or in the Loan Agreement or any of the
other Loan Documents shall be deemed or construed to create a fiduciary relationship between or among the parties.

 

9.Expenses.
The Borrower shall pay the Agent all of its actual, documented and reasonable costs and expenses in connection with the preparation,
negotiation, execution and enforcement of this Amendment in accordance with the Loan Agreement (including, without limitation,
all actual, documented and reasonable fees, expenses and disbursements of counsel to the Agent).

 

10.Miscellaneous.
This Amendment may be executed in any number of counterparts and by different parties hereto in separate counterparts, each of
which, when so executed and delivered, shall be deemed to be an original and all of which counterparts, taken together, shall constitute
but one and the same instrument. This Amendment shall be binding upon and inure to the benefit of the successors and permitted
assigns of the parties hereto. California law governs this Amendment, without regard to principles of conflicts of law. This Amendment
embodies the entire agreement and understanding between the parties hereto with respect to the subject matter hereof and supersedes
all prior oral or written negotiations, agreements and understandings of the parties with respect to the subject matter hereof.
Time is of the essence of this Amendment.

 

[remainder of page intentionally blank]

 

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IN WITNESS WHEREOF,
the parties hereto have caused this Amendment to be executed as of the Effective Date.

 

	BORROWER:	 
	 	 	 
	TRANSGENOMIC, INC.	 
	 	 	 
	By:	/s/ Paul Kinnon	 
	Name:	Paul Kinnon	 
	Title:	President & CEO	 
	 	 	 
	AGENT:	 
	 	 	 
	THIRD SECURITY SENIOR STAFF 2008 LLC	 
	As Agent for Lenders	 
	 	 	 
	By	/s/ Randal J. Kirk	 
	Name:	Randal J. Kirk	 
	Title:	Manager, Third Security, LLC, which is	 
	 	the Manager of Third Security Senior	 
	 	Staff 2008 LLC	 
	 	 	 
	LENDERS:	 
	 	 	 
	THIRD SECURITY SENIOR STAFF 2008 LLC	 
	 	 	 
	By	/s/ Randal J. Kirk	 
	 	Randal J. Kirk	 
	 	Manager, Third Security, LLC, which is the	 
	 	Manager of Third Security Senior Staff 2008 LLC	 
	 	 	 
	THIRD SECURITY STAFF 2010 LLC	 
	 	 	 
	By	/s/ Randal J. Kirk	 
	 	Randal J. Kirk	 
	 	Manager, Third Security, LLC, which is the	 
	 	Manager of Third Security Staff 2010 LLC	 
	 	 	 
	THIRD SECURITY INCENTIVE 2010 LLC	 
	 	 	 
	By	/s/ Randal J. Kirk	 
	 	Randal J. Kirk	 
	 	Manager, Third Security, LLC, which is the	 
	 	Manager of Third Security Incentive 2010 LLC	 

 

[Signature Page to Fourth Amendment]SERIES B CONVERTIBLE PREFERRED STOCK
PURCHASE AGREEMENT

 

THIS SERIES B CONVERTIBLE PREFERRED STOCK
PURCHASE AGREEMENT (this “Agreement”) is made as of this 5th day of March, 2014, by and among Transgenomic, Inc., a
Delaware corporation (the “Company”), and Third Security Senior Staff 2008 LLC, a Virginia limited liability company
(“Senior Staff LLC”), Third Security Staff 2014 LLC, a Virginia limited liability company (“Staff LLC”),
and Third Security Incentive 2010 LLC, a Virginia limited liability company (“Incentive LLC” and, together with Senior
Staff LLC and Staff LLC, the “Purchasers”).

 

WHEREAS, upon the terms and conditions set
forth in this Agreement, the Company proposes to issue and sell to the Purchasers 1,443,297 shares of Series B Convertible Preferred
Stock (the “Series B Preferred”) having the rights, preferences, privileges and restrictions set forth in the Certificate
of Designation in the form attached to this Agreement as Exhibit A.

 

NOW, THEREFORE, in consideration of the
foregoing premises and the mutual covenants and conditions set forth herein, and for good and valuable consideration the receipt
and adequacy of which is hereby acknowledged, the parties hereto agree as follows:

 

ARTICLE I

DEFINITIONS

 

		1.1	Definitions.

 

In addition to the terms defined elsewhere herein, when
used herein, the following terms shall have the meanings indicated hereunder:

 

 

		(a)	“Accredited Investor Questionnaire” means the Accredited Investor Questionnaire in the form attached hereto as
Exhibit F.

 

		(b)	“Act” means the Securities Act of 1933, as amended, and the rules and regulations of the SEC thereunder.

 

		(c)	“Affiliate” shall mean, with respect to any Person, any other Person who controls, is controlled by or is under
common control with such Person.

 

		(d)	“Agreement” means this Agreement as the same may be amended, supplemented or modified in accordance with the terms
hereof.

 

		(e)	“Assets” has the meaning set forth in Section 3.19 of this Agreement.

 

		(f)	“Board of Directors” means the Board of Directors of the Company.

 

		(g)	“Business Day” means any day other than a Saturday, Sunday or other day on which commercial banks in the State
of Delaware are authorized or required by law or executive order to close.

 

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		(h)	“Bylaws” means the Company’s Bylaws, as the same may have been amended and as in effect as of the Closing
Date, in the form attached hereto as Exhibit C.

 

		(i)	“Capital Stock” means all of the Company’s issued and outstanding equity securities.

 

		(j)	“Certificate of Designation” means the certificate of designation setting forth the rights, preferences, privileges
and restrictions of the Series B Preferred, in the form attached hereto as Exhibit A.

 

		(k)	“Certificate of Incorporation” means the Third Amended and Restated Certificate of Incorporation of the Company,
as the same may have been amended and as in effect as of the Closing Date, in the form attached hereto as Exhibit B.

 

		(l)	“Claims” has the meaning set forth in Section 3.5 of this Agreement.

 

		(m)	“Closing” has the meaning set forth in Section 2.2(a) of this Agreement.

 

		(n)	“Closing Date” has the meaning set forth in Section 2.2(a) of this Agreement.

 

		(o)	“Code” means the Internal Revenue Code of 1986, as amended, or any successor statue thereto.

 

		(p)	“Common” means Common Stock, $0.01 par value per share, of the Company, or any other Capital Stock into which such
stock is reclassified or reconstituted.

 

		(q)	“Company” has the meaning assigned to such term in the recitals to this Agreement.

 

		(r)	“Company Disclosure Schedule” means the schedule of exceptions and qualifications to the representations and warranties
made by the Company herein, as furnished to the Purchasers concurrently with the execution and delivery of this Agreement.

 

		(s)	“Compensation Plans” means, without limitation, plans, arrangements or practices that provide for severance pay,
deferred compensation, incentive, bonus or performance awards and stock ownership or stock options.

 

		(t)	“Contractual Obligation(s)” means as to any Person, any agreement, undertaking, contract, indenture, mortgage,
deed of trust or other instrument to which such Person is a party or by which it or any of its property is bound.

 

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		(u)	“Copyright(s)” means any foreign or United States copyright registrations and applications for registration thereof,
and any non-registered copyrights.

 

		(v)	“Environmental Laws” means federal, state, local and foreign laws, principles of common law, civil law, regulations
and codes, as well as orders, decrees, judgments or injunctions issued, promulgated, approved or entered thereunder relating to
pollution, protection of the environment or public health and safety.

 

		(w)	“ERISA” means the Employee Retirement Income Security Act of 1974, as amended.

 

		(x)	“Exchange Act” means the Securities Exchange Act of 1934, as amended, or any similar successor federal statute
and the rules and regulations thereunder, as the same shall be in effect from time to time.

 

		(y)	“Financial Statements” has the meaning set forth in Section 3.11 of this Agreement.

 

		(z)	“GAAP” means U.S. generally accepted accounting principles in effect from time to time.

 

		(aa)	“Governmental Authority(ies)” when used in the singular, means any federal, state or local governmental or quasi-governmental
instrumentality, agency, board, commission or department or any regulatory agency, bureau, commission or authority and, when used
in the plural, means all such entities.

 

		(bb)	“Indebtedness” means, as to any Person, (a) all obligations of such person for borrowed money (including, without
limitation, reimbursement and all other obligations with respect to surety bonds, letters of credit and bankers’ acceptances,
whether or not matured), (b) all obligations of such person evidenced by notes, bonds, debentures or similar instruments, (c) all
obligations of such person to pay the deferred purchase price of property or services, except trade accounts payable and accrued
commercial or trade liabilities arising in the ordinary course of business, (d) all interest rate and currency swaps, caps, collars
and similar agreements or hedging devices under which payments are obligated to be made by such Person, whether periodically or
upon the happening of a contingency, (e) all indebtedness created or arising under any conditional sale or other title retention
agreement with respect to property acquired by such Person (even though the rights and remedies of the seller or lender under such
agreement in the event of default are limited to repossession or sale of such property), (f) all obligations of such Person under
leases which have been or should be, in accordance with GAAP, recorded as capital leases and (g) all indebtedness secured by any
Lien (other than Liens in favor of lessors under leases other than leases included in clause (f)) on any property or asset owned
or held by that Person regardless of whether the indebtedness secured thereby shall have been assumed by that Person or is non-recourse
to the credit of that Person.

 

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		(cc)	“Intellectual Property Rights” means Copyrights, Patents, Trade Secrets, Trademarks, Internet Assets, Mask Works,
software (excluding “off the shelf” software) and other proprietary rights in intellectual property existing under
Requirements of Law.

 

		(dd)	“Internet Assets” mean any internet domain names and other computer user identifiers and any rights in and to sites
on the worldwide web, including rights in and to any text, graphics, audio and video files and html or other code incorporated
in such sites.

 

		(ee)	“Lien” means any mortgage, deed of trust, pledge, hypothecation, assignment, encumbrance, lien (statutory or other)
or preference, priority, right or other security interest or preferential arrangement of any kind or nature whatsoever (excluding
preferred stock and equity related preferences), including, without limitation, those created by, arising under or evidencing substantially
the same economic effect as any of the foregoing.

 

		(ff)	“Losses” means all losses, Claims, or written threats thereof, damages, expenses (including reasonable fees, disbursements
and other charges of counsel incurred) or other liabilities.

 

		(gg)	“Mask Works” means any mask works and registrations and applications for registrations thereof.

 

		(hh)	“Material Adverse Effect” means, subject to any applicable cure or grace periods, a material adverse effect upon
any of (a) the financial condition, operations, business or properties of the Company, except to the extent resulting from (i)
changes in general local, domestic, foreign, or international economic conditions (except to the extent such change has a materially
disproportionate effect on the Company as compared to other similarly situated Persons in the industry in which the Company operates),
(ii) changes affecting generally the industry or industries in which the Company operates (except to the extent such change has
a materially disproportionate effect on the Company as compared to other similarly situated Persons in the industry in which the
Company operates), (iii) acts of war, sabotage or terrorism, military actions or the escalation thereof, (iv) any changes in applicable
laws or accounting rules or principles, including, without limitation, changes in GAAP, (v) any action required by this Agreement
or (vi) the announcement of this Agreement or the transactions contemplated hereby, (b) the ability of the Company to perform its
material obligations under this Agreement or any of the Transaction Documents or (c) the legality, validity or enforceability of
this Agreement or any of the Transaction Documents.

 

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		(ii)	“Material Company IP” has the meaning set forth in Section 3.21(b).

 

		(jj)	“Obligations” means, collectively, all of the Company’s Indebtedness, liabilities and Contractual Obligations.

 

		(kk)	“Orders” has the meaning set forth in Section 3.2 of this Agreement.

 

		(ll)	“Patent(s)” means any foreign or United States patents and patent applications, including any divisionals, continuations,
continuations-in-part, substitutions or reissues thereof, whether or not patents are issued on such applications and whether or
not such applications are modified, withdrawn or resubmitted.

 

		(mm)	“Person” means any individual or group of individuals, firm, corporation, partnership, trust, incorporated or unincorporated
association, joint venture, joint stock company, limited liability company, Governmental Authority or other entity of any kind,
and shall include any successor (by merger or otherwise) of such entity.

 

		(nn)	“Permits” has the meaning set forth in Section 3.6(b) of this Agreement.

 

		(oo)	“Purchased Shares” has the meaning set forth in Section 2.1(a) of this Agreement.

 

		(pp)	“Purchasers” has the meaning assigned to such term in the recitals to this Agreement.

 

		(qq)	“Registration Rights Agreement” means the Registration Rights Agreement to be entered into among the Company and
the Purchasers under the conditions set forth herein, the form of which is attached hereto as Exhibit D.

 

		(rr)	“Requirements of Law” means, as to any Person, any law, statute, treaty, rule, regulation, license or franchise
or determination of an arbitrator or a court or other Governmental Authority, in each case applicable or binding upon such Person
or any of its property or to which such Person or any of its property is subject or pertaining to any or all of the transactions
contemplated or referred to herein.

 

		(ss)	“SEC” means the Securities and Exchange Commission or any similar agency then having jurisdiction to enforce the
Act.

 

		(tt)	“SEC Documents” has the meaning set forth in Section 3.11 of this Agreement.

 

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		(uu)	“Securities Filings” means the filing of a Form D with the SEC under the Act and any filing required to be filed
with the any state by the Company in respect of its issuance of the Series B Preferred.

 

		(vv)	“Series A Preferred” means the Company’s Series A Convertible Preferred Stock, $0.01 par value per share.

 

		(ww)	“Series B Preferred” means the Company’s Series B Convertible Preferred Stock, $0.01 par value per share.

 

		(xx)	“Share Purchase Price” means $4.85, the price per share of the Series B Preferred to be paid by the Purchasers.

 

		(yy)	“Stock Certificate Questionnaire” means the Stock Certificate Questionnaire in the form attached hereto as Exhibit
G.

 

		(zz)	“Taxes” has the meaning set forth in Section 3.12 of this Agreement.

 

		(aaa)	“Trade Secrets” means any scientific or technical information, design, process, procedure, formula or improvement
that derives independent economic value from not being generally known, and not being readily ascertainable through proper means,
to the Company’s competitors or other persons who can obtain economic value from its use. To the fullest extent consistent
with the foregoing, and otherwise lawful, Trade Secrets shall include, without limitation, information and documentation pertaining
to the design, specifications, testing, validation, implementation and customizing techniques and procedures concerning the Company’s
present and future products and services.

 

		(bbb)	“Trademarks” means any foreign or United States trademarks, service marks, trade dress, trade names, brand names,
designs and logos, corporate names, product or service identifiers, whether registered or unregistered, and all registrations and
applications for registration thereof.

 

		(ccc)	“Transaction Documents” means, collectively, this Agreement and the Registration Rights Agreement.

 

		1.2	Accounting Terms; Financial Statements.

 

All accounting terms used herein not expressly defined
in this Agreement shall have the respective meanings given to them in accordance with sound accounting practice. The term “sound
accounting practice” shall mean such accounting practice as, in the opinion of the independent certified public accountants
regularly retained by the Company, conforms at the time to GAAP applied on a consistent basis except for changes with which such
accountants concur.

 

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		1.3	Knowledge of the Company.

 

All references to “Knowledge of the Company”
or any similar phrase means the actual knowledge of those individuals set forth on Schedule 1.3 of the Company Disclosure
Schedule or knowledge any such person would be reasonably expected to have given their position with the Company.

 

ARTICLE II

PURCHASE AND SALE OF SERIES B PREFERRED

 

		2.1	Purchase and Sale of Series B Preferred.

 

		(a)	Subject to the terms and conditions herein set forth, the Company agrees to issue and sell to the Purchasers, and each Purchaser
agrees that it will purchase from the Company, on the Closing Date, such number of shares of Series B Preferred (all of the shares
of Series B Preferred being purchased pursuant to this Section 2.1(a) being referred to herein as the “Purchased Shares”)
set forth opposite such Purchaser’s name on Schedule A hereto for the aggregate purchase price of approximately Seven
Million Dollars ($7,000,000.00).

 

		(b)	The Purchased Shares shall have the preferences and rights set forth in the Certificate of Designation for the Series B Preferred.

 

		2.2	Closing.

 

The closing of the sale and purchase of the Purchased
Shares (the “Closing”) shall take place at the offices of Third Security, LLC at 1881 Grove Avenue, Radford, Virginia
24141, at 10:00 a.m., local time, on March 5, 2014, or at such other time, place and date that the Company and the Purchasers may
agree in writing (the “Closing Date”). On the Closing Date, each Purchaser shall deliver or cause to be delivered payment
of the aggregate purchase price for the Purchased Shares being acquired by such Purchaser, as set forth on Schedule A hereto,
by or on behalf of each Purchaser to the Company by certified check or by wire transfer of immediately available funds to an account
designated in writing by the Company, and the Company shall, within three (3) business days following receipt by the Company of
such payment, deliver the Purchased Shares being acquired by each of the Purchasers in the form of certificates issued in each
Purchaser’s name.

 

		2.3	Use of Proceeds.

 

The Company shall use the proceeds from the sale of
the Purchased Shares hereunder for working capital and general corporate purposes.

 

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ARTICLE III

REPRESENTATIONS, WARRANTIES AND COVENANTS
OF THE COMPANY

 

Except as set forth on the Company Disclosure Schedule, the
Company hereby represents, warrants and covenants to each Purchaser as follows:

 

		3.1	Corporate Existence and Power.

 

The Company (a) is a corporation duly organized, validly
existing and in good standing under the laws of the State of Delaware; (b) has all requisite corporate power and authority to own
and operate its property, to lease the property it operates as lessee and to conduct the business in which it is currently, or
is currently proposed to be, engaged; (c) is licensed and in good standing under the laws of each jurisdiction to which its
ownership, lease or operation of property or the conduct of its business requires such qualification, except to the extent the
failure to do so would not have a Material Adverse Effect; and (d) has the corporate power and authority to execute, deliver and
perform its obligations under this Agreement and each of the other Transaction Documents.

 

		3.2	Authorization; No Contravention.

 

The execution, delivery and performance by the Company
of this Agreement and each of the other Transaction Documents and the transactions contemplated hereby and thereby, including,
without limitation, the sale, issuance and delivery of the Purchased Shares (a) have been duly authorized by all necessary corporate
action of the Company; (b) do not contravene the terms of the Certificate of Incorporation or the Bylaws; and (c) do not violate,
conflict with or result in any breach or contravention of, or the creation of any Lien under, any Contractual Obligation or the
judgment, injunction, writ, award, decree or order of any nature (collectively, “Orders”) of any Governmental Authority
against, or binding upon, the Company, in each case in this clause (c), individually or in the aggregate, as would have a Material
Adverse Effect.

 

		3.3	Governmental Authorization; Third Party Consents.

 

Except as set forth on Schedule 3.3 of the Company
Disclosure Schedule and except for the filing of the Securities Filings and the filing and acceptance of the Certificate of Designation,
no approval, consent, exemption, authorization or other action by, or notice to, or filing with, any Governmental Authority or
any other Person in respect of any Requirement of Law, and no lapse of a waiting period under a Requirement of Law, is necessary
or required in connection with the execution, delivery or performance (including, without limitation, the sale, issuance and delivery
of the Purchased Shares) by, or enforcement against the Company of this Agreement and the other Transaction Documents or the transactions
contemplated hereby and thereby.

 

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		3.4	Binding Effect.

 

This Agreement and each of the other Transaction Documents
have been duly executed and delivered by the Company and constitute the legal, valid and binding obligations of the Company enforceable
against the Company in accordance with their terms, except as enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, fraudulent conveyance or transfer, moratorium or similar laws affecting the enforcement of creditors’ rights
generally or by general principles of equity relating to enforceability (regardless of whether considered in a proceeding at law
or in equity).

 

		3.5	Litigation.

 

There are no actions, suits, proceedings, claims, complaints,
disputes, arbitrations or investigations (collectively, “Claims”) pending or, to the Knowledge of the Company, threatened,
at law, in equity, in arbitration or before any Governmental Authority against the Company. To the Knowledge of the Company, there
is no fact, event or circumstance that is likely to give rise to any Claim. The Company has not received notice of any Order and
no Order has been issued by any court or other Governmental Authority against the Company purporting to enjoin or restrain the
execution, delivery or performance of this Agreement or any of the other Transaction Documents to which it is a party.

 

		3.6	Compliance with Laws.

 

		(a)	The Company is in compliance in all respects with all Requirements of Law and all Orders issued by any court or Governmental
Authority, except where the failure to be in compliance would not have a Material Adverse Effect.

 

		(b)	The Company has all licenses, permits, orders and approvals of any Governmental Authority (collectively, “Permits”)
that are necessary for the conduct of the business of the Company taken as a whole; such Permits are in full force and effect;
and no violations are or have been recorded in respect of any Permit, except in each case, individually or in the aggregate, as
would not have a Material Adverse Effect.

 

		(c)	No material expenditure is presently required by the Company to comply with any existing Requirement of Law or Order.

 

		(d)	None of the Company, any subsidiary or any director, officer, or employee of, or, to the Knowledge of the Company, any agent
or other person associated with or acting on behalf of the Company or any subsidiary has, directly or indirectly: (a) used any
funds of the Company or any subsidiary for unlawful contributions, unlawful gifts, unlawful entertainment or other unlawful expenses
relating to political activity; (b) made any unlawful payment to foreign or domestic governmental officials or employees or to
foreign or domestic political parties or campaigns from funds of the Company or any subsidiary; (c) violated any provision of the
Foreign Corrupt Practices Act of 1977, as amended, rule or regulation issued by the U.S. Office of Foreign Assets Control (“OFAC”)
of the U.S. Treasury Department, the Financial Action Task Force on Money Laundering (“FATF”) or the U.S. Secretary
of the Treasury under Section 311 or 312 of the USA PATRIOT Act or any similar Requirements of Law; (d) established or maintained
any unlawful fund of monies or other assets of the Company or any subsidiary; (e) made any fraudulent entry on the books or records
of the Company or any subsidiary; or (f) made any unlawful bribe, unlawful rebate, unlawful payoff, unlawful influence payment,
unlawful kickback or other unlawful payment to any person, private or public, regardless of form, whether in money, property or
services, to obtain favorable treatment in securing business, to obtain special concessions for the Company or any subsidiary,
to pay for favorable treatment for business secured or to pay for special concessions already obtained for the Company or any subsidiary.

 

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		3.7	Capitalization.

 

On the Closing Date, after giving effect to the issuance
of the Purchased Shares to each of the Purchasers in accordance with the terms hereof, the authorized Capital Stock shall consist
of (a) 150,000,000 shares of Common, of which 7,353,695 will be outstanding and issued, and (b) 15,000,000 shares of Preferred
Stock, par value $0.01 per share, of which (x) 3,879,307 shares are designated as Series A Preferred, of which 2,586,205 shares
will be outstanding and issued, and (y) 1,443,297 shares are designated as Series B Preferred, of which 1,443,297 shares will be
outstanding and issued. Set forth on Schedule 3.7 of the Company Disclosure Schedule is a true and complete list of (i) the stockholders
of record of the Company, and, opposite the name of each such stockholder of record, the amount of all Capital Stock owned by such
stockholder and (ii) the holders of all outstanding options, warrants, conversion privileges, or other rights to purchase or otherwise
acquire any authorized but unissued shares of Capital Stock or other proprietary interests (collectively, “Options”)
and, opposite the name of each such holder, the amount of all Options of the Company owned by such holder. The Company has reserved
a sufficient number of shares of Common for issuance upon conversion of the Purchased Shares, plus such additional number of shares
of Common as may be necessary upon the application of the anti-dilution provisions of the Series B Preferred set forth in the Certificate
of Designation. The Purchased Shares are duly authorized, and, assuming the accuracy of the representations and warranties of the
Purchasers set forth in Article IV, when issued to the Purchasers pursuant to the terms of this Agreement, will be validly issued,
fully paid and nonassessable and, assuming the accuracy of the representations and warranties of the Purchasers in Sections 4.5,
4.6, and 4.7 hereof, will be issued in compliance with (or pursuant to exemptions under) the registration and qualification requirements
of all applicable securities laws. The shares of Common issuable upon conversion of the Purchased Shares are duly authorized and,
when issued in compliance with the provisions of the Certificate of Incorporation, including the Certificate of Designation, will
be validly issued, fully paid and nonassessable and, assuming the accuracy of the representations and warranties of the Purchasers
in Sections 4.5, 4.6, and 4.7 hereof, will be issued in compliance with (or pursuant to exemptions under) the registration and
qualification requirements of all applicable securities laws. If at any time after the date hereof, the Company does not have a
sufficient number of Common authorized and available for issuance upon conversion of the Purchased Shares, the Company and the
Purchasers will jointly cooperate with one another in obtaining the necessary stockholder approval to increase the number of authorized
shares of Common at the Company’s next annual meeting of stockholders; provided, however, that if the Purchasers so
request in writing, in lieu of waiting until the next annual meeting of stockholders, the Company shall call and hold a special
meeting of its stockholders within sixty (60) days of the date such writing is given by the Purchasers for the sole purpose of
increasing the number of authorized shares of Common (such meeting, a “Special Meeting”), and the Company and the Purchasers
will jointly cooperate with one another in obtaining the necessary stockholder approval at such Special Meeting. Notwithstanding
the foregoing, the Company will not be required to hold a Special Meeting within 3 months of (i) the Company's most recent annual
meeting of stockholders or (ii) the one-year anniversary of the Company's most recent annual meeting of stockholders. The outstanding
shares of Capital Stock of the Company are all duly authorized, validly issued, fully paid and nonassessable, and were issued in
compliance with (or pursuant to exemptions under) the registration and qualification requirements of all applicable securities
laws. The Company does not own directly or indirectly, nor has it made any investment in, any Capital Stock of or ownership interest
in any other Person.

 

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		3.8	No Default or Breach; Contractual Obligations.

 

The Company has not received notice of, and is not in
default under, or with respect to, any Contractual Obligation in any respect, which, individually or together with all such defaults,
would have a Material Adverse Effect. All Contractual Obligations of the Company are valid, in full force and effect and binding
upon the Company, and to the Knowledge of the Company, the other parties thereto except in each case, individually or in the aggregate,
as would not have a Material Adverse Effect. To the Knowledge of the Company, no other party to any such Contractual Obligation
is in default thereunder, nor does any condition exist that with notice or lapse of time or both would constitute a default thereunder,
except in each case, individually or in the aggregate, as would not have a Material Adverse Effect.

 

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		3.9	Title to Real Property.

 

The Company has good, record and marketable title in
fee simple to, or holds interests as lessee under leases in full force and effect in, all real property used in connection with
its business or otherwise owned or leased by it, except for such defects in title as would not, individually or in the aggregate,
have a Material Adverse Effect.

 

		3.10	FIRPTA.

 

The Company is not a “foreign person” within
the meaning of Section 1445 of the Code.

 

		3.11	SEC Documents; Financial Statements.

 

The Common is registered pursuant to Section 12(b) of
the Exchange Act. During the two-year period preceding the Closing Date, the Company has timely filed all reports, schedules, forms,
statements and other documents required to be filed by it with the SEC pursuant to the reporting requirements of the Exchange Act
(the “SEC Documents”). At the times of their respective filings, the SEC Documents complied in all material respects
with the requirements of the Exchange Act and the rules and regulations of the SEC promulgated thereunder and other federal, state
and local laws, rules and regulations applicable to such documents. At the times of their respective filings, the SEC Documents
did not contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary
in order to make the statements therein, in light of the circumstances under which they were made, not misleading. The Company
currently meets the “registrant eligibility” requirements set forth in the general instructions to Form S-3 to enable
the registration of the Common. As of their respective dates, the financial statements of the Company included in the SEC Documents
(the “Financial Statements”) complied in all material respects with applicable accounting requirements and the published
rules and regulations of the SEC or other applicable rules and regulations with respect thereto. Such financial statements have
been prepared in accordance with GAAP (except (i) as may be otherwise indicated in such financial statements or the notes thereto
or (ii) in the case of unaudited interim statements, to the extent they may not include footnotes or may be condensed or summary
statements), and fairly present in all material respects the consolidated financial position of the Company as of the dates thereof
and the results of operations and cash flows for the periods then ended (subject, in the case of unaudited statements, to normal
year-end audit adjustments).

 

		3.12	Taxes.

 

		(a)	The Company has paid all federal, state, county, local, foreign and other taxes, including, without limitation, income taxes,
estimated taxes, excise taxes, sales taxes, use taxes, gross receipts taxes, franchise taxes, employment and payroll related taxes,
property taxes and import duties, whether or not measured in whole or in part by net income (hereinafter, “Taxes” or,
individually, a “Tax”) that have come due and are required to be paid by it through the date hereof, and all deficiencies
or other additions to Tax, interest and penalties owed by it in connection with any such Taxes, and shall timely pay any Taxes
including additions, interest and penalties, required to be paid by it on, before or after the date hereof;

 

    	12

    	 

    

 

		(b)	the Company has timely filed returns for Taxes that it is required to file on and through the date hereof and all information
set forth in such Tax returns is correct and complete in all material respects;

 

		(c)	with respect to all Tax returns of the Company, (i) except as set forth in Schedule 3.12, there is no unassessed tax
deficiency proposed or to the Knowledge of the Company threatened against the Company and (ii) except as set forth in Schedule
3.12, no audit is in progress and no extension of time is in force with respect to any date on which any return for Taxes was
or is to be filed and no waiver or agreement is in force for the extension of time for the assessment or payment of any Tax;

 

		(d)	except as set forth in Schedule 3.12, the Company has neither agreed to nor is required to make any adjustments under
Section 481(a) of the Code by reason of a change in accounting methods or otherwise; Schedule 3.12 sets forth the status
of federal income tax audits and state, local and foreign tax audits of the Tax returns of the Company for each taxable year for
which the statute of limitations has not expired; and

 

		(e)	all liabilities for Taxes of the Company attributable to periods prior to the date hereof have been adequately provided for
in the Financial Statements and the liability of the Company for Taxes has not and will not increase at any time up to the Closing
Date other than in the ordinary course of business.

 

		3.13	Changes.

 

Except as disclosed in the SEC Documents, since December
31, 2012 there has not been:

 

		(a)	any change in the assets, liabilities, financial condition or operating results of the Company from that reflected in the Financial
Statements, except changes in the ordinary course of business that have not caused, in the aggregate, a Material Adverse Effect;

 

		(b)	any damage, destruction or loss, whether or not covered by insurance, causing a Material Adverse Effect;

 

    	13

    	 

    

 

		(c)	any waiver or compromise by the Company of a valuable right or of a material debt owed, except in the ordinary course of business;

 

		(d)	any satisfaction or discharge of any Lien by the Company, except in the ordinary course of business;

 

		(e)	any material change or amendment to an Obligation, except in the ordinary course of business;

 

		(f)	receipt of notice that there has been a loss of, or material order cancellation by, any material customer of the Company or
to the Knowledge of the Company any threatened termination, cancellation or limitation of, or any adverse modification or change
in the business relationship of the Company, or the business of the Company, with any material customer or material supplier and,
to the Knowledge of the Company, there exists no present condition or state of fact circumstances that would have a Material Adverse
Effect or prevent the Company from conducting such business relationships or such business with any such material customer or material
supplier in the same manner as heretofore conducted by the Company;

 

		(g)	any Lien, created by the Company, with respect to any of its material properties or assets, except Liens for taxes not yet
due or payable or Liens arising in the ordinary course of business;

 

		(h)	any loans or guarantees made by the Company to or for the benefit of its employees, officers or directors, or any members of
their immediate families, other than advances made in the ordinary course of business;

 

		(i)	any resignation or termination of employment of any Key Employee;

 

		(j)	any declaration, setting aside or payment or other distribution in respect of any of the Company’s Capital Stock (except
for the reservation of shares of Capital Stock pursuant to this Agreement and the Transaction Documents), or any direct or indirect
redemption, purchase or other acquisition of any such stock by the Company; or

 

		(k)	any binding agreement or commitment by the Company to do any of the things described in this Section 3.13.

 

		3.14	Investment Company.

 

The Company is not an “investment company”
within the meaning of the Investment Company Act of 1940, as amended.

 

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		3.15	Private Offering.

 

No form of general solicitation or general advertising
was used by the Company or its representatives in connection with the offer or sales of the Purchased Shares. Assuming the accuracy
of the representations and warranties of the Purchasers, no registration of the Purchased Shares, pursuant to the provisions of
the Act or any state securities or “blue sky” laws, will be required by the offer, sale or issuance of the Purchased
Shares.

 

		3.16	Employee Matters.

 

		(a)	Schedule 3.16 contains a list of all of the individuals who are in the employ of the Company (“Employees”),
including the names, titles and compensation of each. Schedule 3.16 lists (i) all increases in compensation of such Employees
during the previous 12 months other than increases in salary in the ordinary course of business consistent with the Company’s
policies and (ii) any increases in compensation of such Employees that have not yet been effected but which are valid Contractual
Obligations of the Company. To the Company’s Knowledge, no Employee is a party to or is otherwise bound by any agreement
or arrangement (including, without limitation, any license, covenant or commitment of any nature), or subject to any Order, (i)
that would conflict with such Employee’s obligation diligently to promote and further the interests of the Company or (ii)
that would conflict with the Company’s business as now conducted. The Company has complied with all Requirements of Law relating
to the employment of labor, including provisions relating to wages, hours, equal opportunity, collective bargaining and payment
of Social Security and other taxes, except in each case, individually or in the aggregate, as would not have a Material Adverse
Effect.

 

		(b)	Schedule 3.16(b) contains a complete and accurate list of all written employment agreements for the Employees. The employment
agreements include, without limitation, employee leasing agreements, employee services agreements and non-competition agreements.

 

		(c)	No unwritten amendments have been made, whether by oral communication, pattern of conduct or otherwise, with respect to any
Compensation Plans or employment agreements for the Employees.

 

		(d)	None of the Employees listed on Schedule 3.16(d) of the Company Disclosure Schedule (the “Key Employees”)
has any plans to terminate his or her employment with the Company to the Company’s Knowledge, and the Company has no intention
of terminating the employment of any Key Employee.

 

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		3.17	Labor Relations.

 

		(a)	The Company is not engaged in any unfair labor practice under any Requirement of Law;

 

		(b)	there is (i) no grievance or arbitration proceeding arising out of or under collective bargaining agreements pending or, to
the Knowledge of the Company, threatened against the Company, and (ii) no strike, labor dispute, slowdown or stoppage pending or,
to the Knowledge of the Company, threatened against the Company;

		(c)	the Company is not a party to any collective bargaining agreement or contract;

 

		(d)	there is no union representation question existing with respect to the employees of the Company; and

 

		(e)	to the Knowledge of the Company, no union organizing activities are taking place with respect to the employees of the Company.

 

		3.18	Employee Benefit Plans.

 

The Company has no actual or contingent, direct or indirect,
liability in respect of any employee benefit plan or arrangement, including any plan subject to ERISA, other than to administer
and make contributions under or pay benefits pursuant to the plans listed on Schedule 3.18 (collectively, the “Plans”).
All of the Plans are in compliance with all applicable Requirements of Law except to the extent that noncompliance with such Requirements
of Law would not have a Material Adverse Effect. No Plan (a) is subject to Title IV of ERISA, or is otherwise a Defined Benefit
Plan, or is a multiple employer plan (within the meaning of Section 413(c) of the Code); or (b) provides for post-retirement welfare
benefits except to the extent any such benefits are required by law or a “parachute payment” (within the meaning of
Section 280G(b) of the Code) except as set forth on Schedule 3.18. The execution and delivery of this Agreement and each
of the other Transaction Documents, the purchase and sale of the Purchased Shares and the consummation of the transactions contemplated
hereby and thereby will not result in any prohibited transaction by the Company within the meaning of Section 406 of ERISA or Section
4975 of the Code. Schedule 3.18 also sets forth all Compensation Plans of the Company, other than compensation disclosed
on Schedule 3.16.

 

		3.19	Title to Assets.

 

The Company owns and has good and valid title to all
of its properties and assets used in its business and reflected as owned in the Financial Statements or so described in any Schedule
hereto (collectively, the “Assets”), in each case free and clear of all Liens, except for (a) Liens specifically described
in the notes to the Financial Statements, (b) Liens that would not, individually or in the aggregate, have a Material Adverse Effect,
or (c) Liens for Taxes that have not yet become delinquent.

 

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		3.20	Liabilities.

 

The Company has no material liabilities other than (i)
liabilities fully and adequately reflected or reserved against in the Financial Statements, (ii) liabilities not required by GAAP
to be set forth in the Financial Statements and (iii) liabilities incurred since December 31, 2012 in the ordinary course of business
and that will not have a Material Adverse Effect.

 

		3.21	Intellectual Property.

 

		(a)	Except as provided on Schedule 3.21(a) or in the agreements listed in Schedule 3.21(c), the Company is the owner
of or has the license or right to use, sell, license or dispose of all of the Intellectual Property Rights that are used in connection
with the business of the Company as presently conducted, free and clear of all Liens.

 

		(b)	Schedule 3.21(b) sets forth all of the registered Copyrights, Patents, patent applications, registered Trademarks, and
domain names owned or licenses by the Company that are material to the business of the Company as currently conducted. None of
the Intellectual Property Rights that are material to the business of the Company as currently conducted (the “Material Company
IP”) is subject to any outstanding Order, and no Claim is pending or, to the Knowledge of the Company, threatened, which
challenges the validity, enforceability, use or ownership of the item.

 

		(c)	Schedule 3.21(c) sets forth all licenses, sublicenses and other agreements under which the Company is either a licensor
or licensee of any Material Company IP. The Company has performed all material obligations imposed upon it thereunder, and the
Company is not, nor to the Knowledge of the Company is any party thereto in breach of or default thereunder in any material respect,
nor is there any event which with notice or lapse of time or both would constitute a default thereunder. All of the licenses listed
on Schedule 3.21(c) are valid, enforceable and in full force and effect with respect to the Company and, to the Knowledge
of the Company, with respect to the other party or parties to such licenses, and will continue to be so on identical terms immediately
following the Closing, except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, fraudulent
conveyance or transfer, moratorium or similar laws affecting the enforcement of creditors’ rights generally and by general
principles of equity related to enforceability (regardless of whether considered in a proceeding at law or in equity).

 

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		(d)	To the Knowledge of the Company none of the Material Company IP currently sold or licensed by the Company to any Person or
used by or licensed to the Company infringes upon or otherwise violates any Intellectual Property Rights of others.

 

		(e)	No litigation is pending and no Claim has been made against the Company or, to the Knowledge of the Company, is threatened,
contesting the right of the Company to sell or license the Material Company IP to any Person or use the Material Company IP presently
sold or licensed to such Person or used by the Company.

 

		(f)	To the Knowledge of the Company, no Person is infringing upon or otherwise violating the Material Company IP.

 

		(g)	No former employer of any Employee, and no current or former client of any consultant of the Company, has made a claim, or
to the Knowledge of the Company threatened to make a claim, against the Company that such Employee or such consultant is utilizing
proprietary information of such former employer or client.

 

		(h)	To the Knowledge of the Company, no Employee is in material violation of any term of any employment agreement, patent or invention
disclosure agreement or other contract or agreement relating to the relationship of such Employee with the Company.

 

		(i)	None of the Company’s Trade Secrets has been disclosed to any Person other than (i) employees, representatives and agents
of the Company, (ii) as required pursuant to any filings with a Governmental Authority, (iii) when disclosure to a Person is pursuant
to provisions in non-disclosure, consultant, license or other confidentiality agreements entered into by the Company or (iv) in
connection with discussions with possible sources of financing for the Company subject to customary non-disclosure arrangements.

 

		3.22	Potential Conflicts of Interest.

 

Except as disclosed in the SEC Documents or as set forth
on Schedule 3.22, during the two-year period preceding the Closing Date, no event has occurred that would be required to
be reported by the Company pursuant to Item 404(d)(1) of Regulation S-K promulgated by the SEC.

 

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		3.23	Trade Relations.

 

Except as set forth on Schedule 3.23, there exists
no actual or, to the Knowledge of the Company, threatened termination, cancellation or material limitation of, or any adverse modification
or change in, the business relationship of the Company, or the business of the Company, with any customer or any group of customers
whose purchases are individually or in the aggregate material to the Company, or with any material supplier of the Company, and,
to the Knowledge of the Company, there exists no present condition or state of fact or circumstances that would have a Material
Adverse Effect or prevent the Company from conducting such business relationships or such business with any such customer, such
group of customers or such material supplier substantially in the same manner as heretofore conducted by the Company.

 

		3.24	Outstanding Borrowing.

 

Schedule 3.24 sets forth (a) the amount of all
Indebtedness with respect to the Company as of the date hereof, (b) the Liens that relate to such Indebtedness and that encumber
the Assets and (c) the name of each lender thereof.

 

		3.25	Insurance.

 

The Company maintains insurance with insurance companies
in such amounts and covering such risks as are usually and customarily carried by Persons engaged in the business conducted by
the Company. Such policies and binders are valid and enforceable in accordance with their terms and are in full force and effect.
None of such policies will be affected by, or terminate or lapse by reason of, any transaction contemplated by this Agreement or
any of the other Transaction Documents.

 

		3.26	Minute Records.

 

All minutes and written consents since January 1, 2013
of the Board of Directors and stockholders of the Company have been provided or made available to each of the Purchasers. The minutes
and written consents contain a complete summary of all meetings of the Board of Directors and stockholders since January 1, 2013
and reflect all transactions referred to in such minutes and written consents accurately in all material respects.

 

		3.27	Environmental Matters.

 

The Company is and has been in compliance in all respects
with all applicable Environmental Laws except for failures to be in compliance that would not, individually or in the aggregate,
have a Material Adverse Effect. There is no Claim pending or, to the Knowledge of the Company, threatened against the Company pursuant
to Environmental Laws that would reasonably be expected to result in a fine, penalty or other obligation, cost or expense that
would have a Material Adverse Effect; and, there are no past or present events, conditions, circumstances, activities, practices,
incidents, agreements, actions or plans which may prevent compliance with, or which have given rise to or will give rise to liability
under, Environmental Laws except in each case, individually or in the aggregate, as has not had or would not have a Material Adverse
Effect.

 

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		3.28	Broker’s, Finder’s or Similar Fees.

 

Except as set forth on Schedule 3.28, there are
no brokerage commissions, finder’s fees or similar fees or commissions payable by the Company in connection with the transactions
contemplated hereby based on any agreement, arrangement or understanding with the Company or any action taken by any such Person.

 

		3.29	Accountants.

 

McGladrey LLP, whose report on the financial statements
of the Company is filed with the SEC in the Company’s Annual Report on Form 10-K for the year ended December 31, 2012, were,
at the time such report was issued, independent registered public accountants as required by the Act. Except as described in the
SEC Documents and as preapproved in accordance with the requirements set forth in Section 10A of the Exchange Act, to the Knowledge
of the Company, neither McGladrey LLP nor Ernst & Young LLP has engaged in any non-audit services prohibited by subsection
(g) of Section 10A of the Exchange Act on behalf of the Company.

 

		3.30	Internal Controls.

 

The Company has established and maintains a system of
internal accounting controls sufficient to provide reasonable assurances that: (i) transactions are executed in accordance with
management’s general or specific authorization; (ii) transactions are recorded as necessary to permit preparation of
financial statements in conformity with GAAP and to maintain accountability for assets; (iii) access to assets is permitted only
in accordance with management’s general or specific authorization; and (iv) the recorded accountability for assets is compared
with existing assets at reasonable intervals and appropriate action is taken with respect to any differences.

 

		3.31	Corporate Governance.

 

The Board of Directors meets the independence requirements
of, and has established an audit committee that meets the independence requirements of, the rules and regulations of the SEC. The
Audit Committee has reviewed the adequacy of its charter within the past 12 months.

 

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		3.32	Disclosure Controls.

 

The Company has established and maintains disclosure
controls and procedures (as such term is defined in Rules 13a-15 and 15d-15 under the Exchange Act). Since the date of the most
recent evaluation of such disclosure controls and procedures, there have been no significant changes in internal controls or in
other factors that could significantly affect internal controls, including any corrective actions with regard to significant deficiencies
and material weaknesses. The Company is in compliance in all material respects with all provisions currently in effect and applicable
to the Company of the Sarbanes-Oxley Act of 2002, and all rules and regulations promulgated thereunder or implementing the provisions
thereof.

 

		3.33	No Undisclosed Events or Circumstances.

 

Except as disclosed in the SEC Documents, since December
31, 2012, except for the consummation of the transactions contemplated herein, to the Company’s Knowledge, no event or circumstance
has occurred or exists with respect to the Company or its businesses, properties, prospects, operations or financial condition,
which, under any Requirement of Law, requires public disclosure or announcement by the Company but which has not been so publicly
announced or disclosed.

 

		3.34	Application of Takeover Provisions.

 

The issuance of the Series B Preferred pursuant hereto
and the Purchasers’ ownership thereof is not prohibited by the business combination statutes of the state of Delaware or
the Certificate of Incorporation. The Company has not adopted any stockholder rights plan, “poison pill” or similar
arrangement that would trigger any right, obligation or event as a result of the issuance of such securities and the Purchasers’
ownership of such securities and there are no similar anti-takeover provisions under the Certificate of Incorporation. In addition,
the Company covenants and agrees that, from and after the Closing Date, it will not adopt any such anti-takeover provisions, whether
under its Certificate or otherwise, that would be applicable to the Purchasers or any of their respective Affiliates.

 

		3.35	No Stockholder Approval.

 

No approval of the stockholders of the Company is required
under law or otherwise for the Company to issue and deliver to the Purchasers the shares of Series B Preferred as contemplated
hereby.

 

		3.36	Disclosure.

 

		(a)	Agreement and Other Documents. This Agreement and the documents and certificates furnished to the Purchasers by the
Company, including but not limited to the SEC Documents, do not contain any untrue statement of a material fact or omit to state
a material fact necessary in order to make the statements contained herein or therein, in the light of the circumstances under
which they were made, not misleading.

 

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		(b)	Material Adverse Effects. To the Knowledge of the Company, there is no fact which the Company has not disclosed to each
of the Purchasers in writing which would have a Material Adverse Effect.

 

ARTICLE IV

REPRESENTATIONS AND WARRANTIES OF THE
PURCHASERS

 

Each Purchaser hereby represents and warrants to the Company
as follows:

 

		4.1	Existence and Power.

 

The Purchaser is duly organized, validly existing and
in good standing under the laws of the Commonwealth of Virginia and has the power and authority to execute, deliver and perform
its obligations under this Agreement and each of the other Transaction Documents.

 

		4.2	Authorization; No Contravention.

 

The execution, delivery and performance by the Purchaser
of this Agreement and each of the other Transaction Documents to which it is a party and the transactions contemplated hereby and
thereby, including, without limitation, the purchase of the Purchased Shares, (a) have been duly authorized by all necessary action,
(b) do not contravene the terms of the Purchaser’s organizational documents, or any amendment thereof, and (c) do not violate,
conflict with or result in any breach or contravention of or the creation of any Lien under, any Contractual Obligation of the
Purchaser, or any Orders of any Governmental Authority or Requirement of Law applicable to the Purchaser in each case, individually
or in the aggregate, as would have a material adverse effect on (i) the ability of the Purchaser to perform its material obligations
under this Agreement or any of the other Transaction Documents or (ii) the legality, validity or enforceability of this Agreement
or any of the other Transaction Documents.

 

		4.3	Governmental Authorization; Third Party Consents.

 

No approval, consent, exemption, authorization, or other
action by, or notice to, or filing with, any Governmental Authority or any other person with respect to any Requirement of Law,
and no lapse of a waiting period under any Requirement of Law, is necessary or required in connection with the execution, delivery
or performance (including, without limitation, the purchase of the Purchased Shares) by, or enforcement against, the Purchaser
of this Agreement and each of the other Transaction Documents to which the Purchaser is a party or the transactions contemplated
hereby and thereby.

 

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		4.4	Binding Effect.

 

This Agreement and each of the other Transaction Documents
to which the Purchaser is a party have been duly executed and delivered by the Purchaser and constitute the legal, valid and binding
obligations of the Purchaser, enforceable against the Purchaser in accordance with its terms, except as enforceability may be limited
by applicable bankruptcy, insolvency, reorganization, fraudulent conveyance or transfer, moratorium or similar laws affecting the
enforcement of creditors’ rights generally or by equitable principles relating to enforceability (regardless of whether considered
in a proceeding at law or in equity).

 

		4.5	Purchase for Own Account.

 

The Purchased Shares and the shares of Capital Stock
issuable upon conversion thereof that are being acquired by the Purchaser pursuant to this Agreement are being or will be acquired
for its own account and with no intention of distributing or reselling such securities or any part thereof in any transaction that
would be in violation of the securities laws of the United States of America, or any state, without prejudice, however, to the
rights of the Purchaser at all times to sell or otherwise dispose of all or any part of such securities under an effective registration
statement under the Act, or under an exemption from such registration available under the Act. If the Purchaser should in the future
decide to dispose of any of such securities, the Purchaser understands and agrees that it may do so only in compliance with the
Act and applicable state securities laws, as then in effect.

 

		4.6	Restricted Securities.

 

The Purchaser understands that the Purchased Shares
will not be registered at the time of their issuance under the Act for the reason that the sale provided for in this Agreement
is exempt pursuant to Section 4(2) of the Act and that the reliance of the Company on such exemption is predicated in part on the
Purchaser’s representations set forth herein. The Purchaser represents that it is experienced in evaluating companies such
as the Company, has such knowledge and experience in financial and business matters as to be capable of evaluating the merits and
risks of its investment and has the ability to suffer the total loss of its investment. The Purchaser further represents that it
has had the opportunity to ask questions of and receive answers from the Company concerning the terms and conditions of the offering
and to obtain additional information to such Purchaser’s satisfaction.

 

		4.7	Accredited Investor Status.

 

At the time such Purchaser was offered the Shares, it
was, and at the date hereof it is, and on the Closing Date it will be, an “accredited investor” as defined in Rule
501(a) under the Securities Act.

 

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		4.8	Accuracy of Accredited Investor Questionnaire.

 

The Accredited Investor Questionnaire delivered by such
Purchaser in connection with this Agreement is complete and accurate in all respects as of the date of this Agreement and will
be correct as of the Closing Date.

 

		4.9	Residency.

 

Such Purchaser’s offices in which its investment
decision with respect to the Purchased Shares was made are located at the address immediately below such Purchaser’s name
on its signature page hereto.

 

		4.10	Certain Trading Activities.

 

Such Purchaser has not directly or indirectly engaged
in any Short Sales involving the Company’s securities since the time that it was first contacted by the Company with respect
to the transactions contemplated hereby. “Short Sales” include, without limitation, all “short sales” as
defined in Rule 200 promulgated under Regulation SHO under the Exchange Act and all types of direct and indirect stock pledges,
forward sale contracts, options, puts, calls, short sales, swaps and similar arrangements (including on a total return basis),
and sales and other transactions through non-US broker dealers or foreign regulated brokers. Notwithstanding the foregoing, in
the case of a Purchaser that is or is part of a multi-managed investment vehicle (a “Fund”) whereby separate portfolio
managers manage separate portions of such Fund’s assets and the portfolio managers have no direct knowledge of the investment
decisions made by the portfolio managers managing other portions of such Fund’s assets, the representation set forth above
shall solely apply with respect to the portion of assets of such Purchaser managed by the portfolio manager that made the investment
decision to purchase the Purchased Shares. Such Purchaser hereby covenants and agrees not to engage, directly or indirectly, in
any transactions in the securities of the Company or involving the Company’s securities during the period from the date hereof
until such time as (i) the transactions contemplated by this Agreement are first publicly announced or (ii) this Agreement
is terminated in full. Notwithstanding the foregoing, for avoidance of doubt, nothing contained herein shall constitute a representation
or warranty, or preclude any actions, with respect to the identification of the availability of, or securing of, available shares
to borrow in order to effect short sales or similar transactions in the future.

 

		4.11	Litigation.

 

There are no Claims pending or, to the knowledge of
the Purchaser, threatened, at law, in equity, in arbitration or before any Governmental Authority against the Purchaser that, individually
or in the aggregate, would have a material adverse effect on (i) the ability of the Purchaser to perform its material obligations
under this Agreement or any of the other Transaction Documents or (ii) the legality, validity or enforceability of this Agreement
or any of the other Transaction Documents. No Order has been issued by any court or other Governmental Authority against the Purchaser
purporting to enjoin or restrain the execution, delivery or performance of this Agreement or any of the other Transaction Documents.

 

    	24

    	 

    

 

		4.12	Broker’s, Finder’s or Similar Fees.

 

There are no brokerage commissions, finder’s fees
or similar fees or commissions payable by the Purchaser, in connection with the transactions contemplated hereby based on any agreement,
arrangement or understanding with the Purchaser or any action taken by the Purchaser.

 

		4.13	Inquiries and Access; No Reliance.

 

The Company has provided the Purchaser the opportunity
to ask questions of the Company and has provided full access to its facilities and personnel in response to any request therefor
that the Purchaser and his or its purchaser representative(s), if any, have made, concerning the Company and its activities, and
all other matters relating to the operations of the Company and the offering and sale of the Purchased Shares. Such Purchaser acknowledges
that he or it is not relying upon any other investor or any officer, director, stockholder, employee, agent, partner or Affiliate
of any such investor in making his or its investment, or decision to invest, in the Company or in monitoring such investment. In
addition, the purchase of the Purchased Shares and the consummation of the transactions contemplated hereunder by the Purchaser
are not done in reliance upon any warranty or representation by, or information from, the Company of any sort, oral or written,
except the warranties and representations specifically set forth in this Agreement (including the schedules and exhibits hereto)
and in any certificates required to be delivered to the Purchaser by the Company hereunder and thereunder. Such purchase and consummation
are instead done entirely on the basis of the Purchaser’s own investigation, analysis, judgment and assessment of the present
and potential value and earning power of the Company as well as those representations and warranties by the Company specifically
set forth in this Agreement (including the schedules and exhibits hereto) and in any certificates required to be delivered to the
Purchaser by the Company hereunder and thereunder. In no respect does this Section 4.13 limit the representations and warranties
contained in Article III of this Agreement.

 

ARTICLE V

CONDITIONS TO THE OBLIGATION OF THE PURCHASERS
TO CLOSE

 

The obligation of each of the Purchasers
(i) to purchase the Purchased Shares pursuant to the terms of this Agreement and (ii) to perform any obligations hereunder with
respect to the Closing shall be subject to the satisfaction as reasonably determined by, or waiver by, each of the Purchasers of
the following conditions on or before the Closing Date.

 

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		5.1	Representations and Warranties.

 

The representations and warranties of the Company contained
in Article III hereof shall be true and correct at and on the Closing Date as if made at and on such date.

 

		5.2	Compliance with this Agreement.

 

The Company shall have performed and complied with all
of its agreements and conditions set forth herein that are required to be performed or complied with by the Company on or before
the Closing Date.

 

		5.3	Secretary’s Certificate.

 

The Secretary of the Company shall deliver to each of
the Purchasers a certificate certifying from the Company, in form and substance satisfactory to each of the Purchasers, dated the
Closing Date and signed by the Secretary of the Company, certifying (a) that the attached copies of the Certificate of Incorporation,
Certificate of Designation, the Bylaws and resolutions of the Board of Directors approving this Agreement and each of the other
Transaction Documents to which the Company is a party and the transactions contemplated hereby and thereby, are all true, complete
and correct and remain unamended and in full force and effect and (b) as to the incumbency and specimen signature of each officer
of the Company executing this Agreement, each other Transaction Document and any other document delivered in connection herewith
on behalf of the Company.

 

		5.4	Filing of the Certificate of Designation.

 

The Certificate of Designation shall have been duly
filed by the Company with and accepted by the Delaware Secretary of State and be in full force and effect.

 

		5.5	Registration Rights Agreement.

 

As of the Closing Date, the Company and the Purchasers
shall have duly executed and delivered the Registration Rights Agreement.

 

		5.6	Consents and Approvals.

 

Except for the Securities Filings or with respect to
the matters set forth on Schedule 3.3 of the Company Disclosure Schedule, all consents, exemptions, authorizations, or other
action by, or notices to, or filings with, Governmental Authorities and other Persons required in respect of all Requirements of
Law and with respect to those Contractual Obligations of the Company that are necessary in connection with the execution, delivery
or performance by, or enforcement against, the Company of this Agreement and each of the other Transaction Documents shall have
been obtained and be in full force and effect, and each of the Purchasers shall have been furnished with appropriate evidence thereof.

 

    	26

    	 

    

 

		5.7	No Application of Anti-Takeover Provisions.

  

The Company’s Board of Directors, to the extent
permissible under Delaware law, shall have taken all necessary action such that any provisions contained in the Certificate of
Incorporation or Delaware law that may apply to business combinations or other transactions with affiliated stockholders or impact
the voting rights of affiliated stockholders shall not apply to the Purchasers or their Affiliates, including but not limited to
Section 203 of the Delaware General Corporation Law. The Company shall not have adopted any stockholder rights plan, “poison
pill” or similar arrangement, or any anti-takeover provisions under its charter documents, that would trigger any right,
obligation or event as a result of the issuance of the Series B Preferred pursuant hereto to the Purchasers or the Purchasers’
ownership of such securities, or the accumulation of Company securities acquired in the market by the Purchasers or their respective
Affiliates.

 

		5.8	No Material Judgment or Order.

 

There shall not be on the Closing Date any Order of
a court of competent jurisdiction or any ruling of any Governmental Authority or any condition imposed under any Requirement of
Law that, in the reasonable judgment of the Purchasers, would prohibit the purchase of the Purchased Shares or subject any of the
Purchasers to any penalty or other onerous condition under or pursuant to any Requirement of Law if the Purchased Shares were to
be purchased hereunder.

 

		5.9	No Litigation.

 

No action, suit proceeding, claim or dispute shall have
been brought or otherwise arisen at law, in equity, in arbitration or before any Governmental Authority against the Company that,
if adversely determined, would have, individually or in the aggregate, a material adverse effect on (i) the ability of the Company
to perform its material obligations under this Agreement or any of the other Transaction Documents or (ii) the legality, validity
or enforceability of this Agreement or any of the other Transaction Documents.

 

		5.10	Opinion of Company Counsel.

 

Purchasers and the Company shall have received from
Paul Hastings LLP, counsel to the Company, an opinion, dated as of the Closing, in the form attached hereto as Exhibit E.

 

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		5.11	Preemptive Rights.

 

All stockholders of the Company having any preemptive,
first refusal or other rights with respect to the issuance of the Purchased Shares shall have irrevocably waived the same in writing.

 

		5.12	No Suspension of Trading.

 

Trading in the Common shall not have been suspended
by the SEC or otherwise.

 

ARTICLE VI

CONDITIONS TO THE OBLIGATIONS OF THE
COMPANY TO CLOSE

 

The obligation of the Company to issue and
sell the Purchased Shares and the obligation of the Company to perform its other obligations hereunder shall be subject to the
satisfaction as reasonably determined by, or written waiver by, the Company of the following conditions on or before the Closing
Date.

 

		6.1	Representations and Warranties.

 

The representation and warranties of each of the Purchasers
contained in Article IV hereof shall be true and correct at and on the Closing Date as if made at and on such date.

 

		6.2	Compliance with this Agreement.

 

Each Purchaser shall have performed and complied with
all of the agreements and conditions set forth herein that are required to be performed or complied with by such Purchaser on or
before the Closing Date.

 

		6.3	Registration Rights Agreement.

 

Each Purchaser shall have duly executed and delivered
the Registration Rights Agreement.

 

		6.4	Questionnaires.

 

Each Purchaser shall have duly executed and delivered
to the Company an Accredited Investor Questionnaire, satisfactory to the Company, and Stock Certificate Questionnaire, in the forms
attached hereto as Exhibits F and G, respectively.

 

		6.5	No Material Judgment or Order.

 

There shall not be on the Closing Date any Order of
a court of competent jurisdiction or any ruling of any Governmental Authority or any condition imposed under any Requirement of
Law that, in the reasonable judgment of the Company, would prohibit the sale of the Purchased Shares or subject the Company to
any penalty or other onerous condition under or pursuant to any Requirement of Law if the Purchased Shares to be purchased hereunder.

 

    	28

    	 

    

 

		6.6	No Litigation.

 

No action, suit proceeding, claim or dispute shall have
been brought or otherwise arisen at law, in equity, in arbitration or before any Governmental Authority against the Purchasers
that, if adversely determined, would have, individually or in the aggregate, a material adverse effect on (i) the ability of the
Purchasers to perform their respective material obligations under this Agreement or any of the other Transaction Documents or (ii)
the legality, validity or enforceability of this Agreement or any of the other Transaction Documents.

 

		6.7	Consents and Approvals.

 

Except for the Securities Filings, all consents, exemptions,
authorizations, or other action by, or notices to, or filings with, Governmental Authorities and other Persons required in respect
of all Requirements of Law and with respect to those Contractual Obligations of the Purchasers that are necessary in connection
with the execution, delivery or performance by, or enforcement against, the Purchasers of this Agreement shall have been obtained
and be in full force and effect, and the Company shall have been furnished with appropriate evidence thereof.

 

ARTICLE VII

MISCELLANEOUS

 

		7.1	Survival of Representations and Warranties.

 

All of the representations and warranties made herein
shall survive the execution and delivery of this Agreement and expire twenty-four (24) months after the Closing Date, except for
(a) Sections 3.1, 3.2, 3.4, 3.7, 4.1, 4.2, 4.4, 4.5 and 4.7 which
representations and warranties shall survive indefinitely, and (b) Section 3.12, which shall survive until the later to
occur of (i) the lapse of the statue of limitations with respect to the assessment of any Tax to which such representation and
warranty related (including any extensions or waivers thereof) and (ii) 60 days after the final administrative or judicial determination
of the Taxes to which such representation and warranty relates, and no Claim with respect to Section 3.12 may be asserted
thereafter with the exception of Claims arising out of any fact, circumstance, action or proceeding to which the party asserting
such Claim shall have given notice to the other parties to this Agreement prior to the termination of such period of reasonable
belief that a tax liability will subsequently arise therefrom.

 

    	29

    	 

    

 

		7.2	Notices.

 

All notices, demands and other communications provided
for or permitted hereunder shall be made in writing and shall be by registered or certified first-class mail, return receipt requested,
telecopier, courier service or personal delivery:

 

		(a)	if to the Company:

 

Transgenomic, Inc.

12325 Emmet Street

Omaha, Nebraska 68164

Attention: Chief Financial Officer

Facsimile: 402-452-5401

 

with a copy to:

 

Paul Hastings LLP

1117 S. California Avenue

Palo Alto, California 94304

Attention: Jeffrey T. Hartlin

Facsimile: 650-320-1904

 

and

 

		(b)	if to the Purchasers:

 

c/o Third Security, LLC

1881 Grove Avenue

Radford, Virginia 24141

Attention: Tad Fisher

Facsimile: 540-633-7939

 

with a copy to:

 

Troutman Sanders LLP

Troutman Sanders Building

1001 Haxall Point

Richmond, Virginia 23219

Attention: John Owen Gwathmey

Facsimile: 804-698-5174

 

All such notices and communications shall be deemed
to have been duly given when delivered by hand, if personally delivered; when delivered by courier, if delivered by commercial
courier service; five (5) Business Days after being deposited in the mail, postage prepaid, if mailed; and when receipt is mechanically
acknowledged, if telecopied.

 

    	30

    	 

    

 

		7.3	Successors and Assigns; Third Party Beneficiaries.

 

This Agreement shall inure to the benefit of and be
binding upon the successors and permitted assigns of the parties hereto. Subject to applicable securities laws the Purchasers may
assign any of their rights under any of the Transaction Documents to any of their Affiliates. The Company may not assign any of
their rights under this Agreement without the written consent of the Purchasers. No person other than the parties hereto and their
successors are intended to be beneficiaries of the provisions of this Agreement.

 

		7.4	Amendment and Waiver.

 

		(a)	No failure or delay on the part of the Company or Purchasers in exercising any right, power or remedy hereunder shall operate
as a waiver thereof, nor shall any single or partial exercise of any such right, power or remedy preclude any other or further
exercise thereof or the exercise of any other right, power or remedy. The remedies provided for herein are cumulative and are not
exclusive of any remedies that may be available to the Company or the Purchasers at law, in equity or otherwise.

 

		(b)	Any amendment, supplement or modification of or to any provision of this Agreement, any waiver of any provision of this Agreement,
and any consent to any departure by the Company or the Purchasers from the terms of any provision of this Agreement, shall be effective
(i) only if it is made or given in writing and signed by the Company and the Purchasers, and (ii) only in the specific instance
and for the specific purpose for which made or given. Except where notice is specifically required by this Agreement, no notice
to or demand on the Company in any case shall entitle the Company to any other further notice or demand in similar or other circumstances.

 

		7.5	Counterparts; Facsimile.

 

This Agreement may be executed in any number of counterparts
and by the parties hereto in separate counterparts, each of which when so executed shall be deemed to be an original and all of
which taken together shall constitute one and the same agreement, and may be delivered to the other parties hereto by facsimile
or similar electronic means.

 

    	31

    	 

    

 

		7.6	Headings.

 

The headings in this Agreement are for convenience of
reference only and shall not limit or otherwise affect the meaning hereof.

 

		7.7	Governing Law.

 

This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware, without regard to the principles of conflicts of law thereof.

 

		7.8	Severability.

 

If any one or more of the provisions contained herein,
or the application thereof in any circumstance, is held invalid, illegal or unenforceable in any respect for any reason, the validity,
legality and enforceability of any such provision in every other respect and of the remaining provisions hereof shall not be in
any way impaired, unless the provision held invalid, illegal or unenforceable shall substantially impair the benefits of the remaining
provisions hereof.

 

		7.9	Rules of Construction.

 

Unless the context otherwise requires, references to
sections or subsections refer to sections or subsections of this Agreement.

 

		7.10	Entire Agreement.

 

This Agreement, together with the exhibits and schedules
hereto, and the other Transaction Documents are intended by the parties as a final expression of their agreement and intended to
be a complete and exclusive statement of the agreement and understanding of the parties hereto in respect of the subject matter
contained herein and therein. There are no restrictions, promises, representations, warranties or undertakings, other than those
set forth or referred to herein or therein. This Agreement, together with the exhibits and schedules hereto, and the other Transaction
Documents supersede all prior agreements and understandings between the parties with respect to such subject matter.

 

		7.11	Publicity; Confidentiality.

 

None of the parties hereto shall issue a publicity release
or public announcement or otherwise make any disclosure concerning this Agreement or the transactions contemplated hereby or the
Purchasers without prior approval by the other parties hereto; provided, however, that nothing in this Agreement
shall restrict the Purchasers or the Company from disclosing information (a) that is already publicly available, (b) that was known
to the Purchasers on a non-confidential basis prior to its disclosure by the Company, (c) that may be required or appropriate in
response to any summons or subpoena or in connection with any litigation, provided that the parties will use reasonable
efforts to notify the other party in advance of such disclosure so as to permit such party to seek a protective order or otherwise
contest such disclosure, and such other party will use reasonable efforts to cooperate, at the expense of the party trying to prevent
such disclosure, with such party in pursuing any such protective order, (d) to the Purchaser’s or the Company’s officers,
directors, agents, employees, members, partners, controlling persons, auditors or counsel, (e) to Persons from whom releases, consents
or approvals are required, or to whom notice is required to be provided, pursuant to the transactions contemplated by the Transaction
Documents or (f) to the prospective transferee in connection with any contemplated transfer of any of the Purchased Shares. If
any announcement is required by law or the rules of any securities exchange or market on which shares of Common are traded to be
made by any party hereto, prior to making such announcement such party will deliver a draft of such announcement to the other party
and shall give the other party reasonable opportunity to comment thereon.

 

    	32

    	 

    

 

		7.12	Further Assurances.

 

Each of the parties shall execute such documents and
perform such further acts, at the expense of the requesting party, (including, without limitation, obtaining any consents, exemptions,
authorizations or other action by, or giving any notices to, or making any filings with, any Governmental Authority or any other
Person) as may be reasonably required or desirable to carry out or to perform the provisions of this Agreement.

 

		7.13	Expenses. Each party hereto shall be responsible for its own fees and expenses associated with this Agreement and the
closing of the transactions contemplated hereby; provided, however, that at the Closing the Company shall reimburse
the Purchasers for all reasonable documented fees and expenses (including attorney’s fees) incurred by the Purchasers in
connection with the transactions contemplated by this Agreement, up to a maximum of $50,000.

 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

 

    	33

    	 

    

 

IN WITNESS WHEREOF,
the parties hereto have caused this Agreement to be executed and delivered by their respective officers hereunto duly authorized
on the date first above written.

 

	COMPANY:	TRANSGENOMIC, INC.
	 	 
	 	By:	/s/ Paul Kinnon
	 	 	Name: Paul Kinnon
	 	 	Title: CEO and President
	 	 
	PURCHASERS:	THIRD SECURITY SENIOR STAFF 2008 LLC
	 	 
	 	By:	/s/ Randal J. Kirk
	 	 	Name: Randal J. Kirk
	 	 	Title: Manager, Third Security, LLC, which is the Manager of Third Security Senior Staff 2008 LLC
	 	 
	 	THIRD SECURITY STAFF 2014 LLC
	 	 
	 	By:	/s/ Randal J. Kirk
	 	 	Name: Randal J. Kirk
	 	 	Title: Manager, Third Security, LLC, which is the Manager of Third Security Staff 2014 LLC
	 	 
	 	THIRD SECURITY INCENTIVE 2010 LLC
	 	 
	 	By:  	/s/ Randal J. Kirk
	 	 	Name: Randal J. Kirk
	 	 	Title: Manager, Third Security, LLC, which is the Manager of Third Security Incentive 2010 LLC

 

[Signature Page to Series B Convertible
Preferred Stock Purchase Agreement]

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