Document:

EX-4.1

 Exhibit 4.1 

 
  

BANCO SANTANDER, S.A. 
 as
Issuer, 
 THE BANK OF NEW YORK MELLON, 

London Branch 
 as Trustee
and Principal Paying Agent 
 and 

THE BANK OF NEW YORK MELLON SA/NV, 

Luxembourg Branch 
 as
Senior Preferred Debt Securities Registrar 
  

 
 SECOND
SUPPLEMENTAL INDENTURE 
 dated as of March 24, 2022 

to 
 SENIOR PREFERRED DEBT
SECURITIES INDENTURE 
 dated as of June 30, 2021 
  

 

 SECOND SUPPLEMENTAL INDENTURE (“Second Supplemental Indenture”),
dated as of March 24, 2022, among BANCO SANTANDER, S.A., a sociedad anónima incorporated under the laws of The Kingdom of Spain (the “Company”), having its principal executive office located at
Ciudad Grupo Santander, Avenida de Cantabria s/n, 28660 Boadilla del Monte, Madrid, Spain, as Issuer, THE BANK OF NEW YORK MELLON, London Branch, a banking corporation duly organized and existing under the laws of the State of New York, as trustee
(the “Trustee,” which term includes any successor Trustee) and principal paying agent (the “Principal Paying Agent,” which term includes any successor Principal Paying Agent), having its Corporate Trust Office at
One Canada Square, London, E14 5AL, United Kingdom, and THE BANK OF NEW YORK MELLON SA/NV, Luxembourg Branch, a société anonyme/naamloze vennootschap, incorporated under the laws of Belgium, as senior
preferred debt securities registrar (the “Senior Preferred Debt Securities Registrar”), having its principal office at 2-4 Rue Eugène Ruppert, L-2453 Luxembourg, Luxembourg. 
 WITNESSETH 

WHEREAS, the Company and the Trustee have executed and delivered a Senior Preferred Debt Securities Indenture dated as of June 30, 2021
(as heretofore supplemented and amended, the “Base Indenture” and, the Base Indenture, as supplemented and amended by this Second Supplemental Indenture, the “Senior Preferred Debt Securities Indenture”), to
provide for the issuance of the Company’s senior preferred debt securities (the “Senior Preferred Debt Securities”), including the Senior Preferred Notes (as defined below). 

WHEREAS, Section 9.01(d) of the Base Indenture permits the Company and the Trustee to change or eliminate any provisions of the Base
Indenture without the consent of Holders, subject to certain conditions; 
 WHEREAS, Section 9.01(f) of the Base Indenture permits the
Company and the Trustee to enter into a supplemental indenture to establish the forms or terms of Senior Preferred Debt Securities of any series as permitted under Sections 2.01 and 3.01 of the Base Indenture without the consent of Holders; 

WHEREAS, there are no Outstanding Senior Preferred Debt Securities of any series created prior to the execution of this Second Supplemental
Indenture that are entitled to the benefit of the provisions set forth herein or that would be adversely affected by such provisions; 

WHEREAS, the Executive Committee of the Company has authorized the entry into this Second Supplemental Indenture and the establishment of the
Senior Preferred Notes (as defined below), as required by Section 9.01 of the Base Indenture; 

  
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 WHEREAS, the parties hereto desire to establish a series of Senior Preferred Debt Securities
to be known as the Series 140 3.496% Senior Preferred Fixed Rate Notes due 2025 (the “Senior Preferred Notes”) pursuant to Sections 2.01 and 3.01 of the Base Indenture. The Senior Preferred Notes may be issued from time to time, and
any Senior Preferred Notes issued as part of the series created herein will constitute a single series of Senior Preferred Debt Securities under the Senior Preferred Debt Securities Indenture and shall be included in the definition of “Senior
Preferred Notes” where the context requires; 
 WHEREAS, the Company has requested and hereby requests that the Trustee execute and
deliver this Second Supplemental Indenture and the Company has provided the Trustee with an Executive Committee Resolution authorizing the execution of this Second Supplemental Indenture; 

WHEREAS, all actions required by the Company to be taken in order to make this Second Supplemental Indenture a valid, binding and enforceable
instrument in accordance with its terms, have been taken and performed, and the execution and delivery of this Second Supplemental Indenture has been duly authorized in all respects; and 

WHEREAS, where indicated, this Second Supplemental Indenture shall amend and supplement the Base Indenture; and to the extent that the terms
of the Base Indenture are inconsistent with such provisions of this Second Supplemental Indenture, the terms of this Second Supplemental Indenture shall govern. 

NOW, THEREFORE, the Company and the Trustee mutually covenant and agree as follows: 

ARTICLE 1 
 DEFINITIONS 

Section 1.01. Definition of Terms. For all purposes of this Second Supplemental Indenture: 

(a) a term defined anywhere in this Second Supplemental Indenture has the same meaning throughout; 

(b) capitalized terms used herein but not otherwise defined shall have the meanings assigned to them in the Base Indenture; 

(c) the singular includes the plural and vice versa; 

(d) headings are for convenience of reference only and do not affect interpretation; and 

(e) for the purposes of this Second Supplemental Indenture and the Base Indenture, the term “series” shall mean a series of the
Senior Preferred Debt Securities. 

  
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 ARTICLE 2 

FORM OF SENIOR PREFERRED NOTES 

Section 2.01. Terms of the Senior Preferred Notes. The following terms relating to the Senior Preferred Notes are hereby
established pursuant to Section 3.01 of the Base Indenture: 
 (a) The Senior Preferred Notes shall be designated as: the Series 140
3.496% Senior Preferred Fixed Rate Notes due 2025; 
 (b) The price at which the Senior Preferred Notes shall be issued is 100.000% of the
principal amount thereof; 
 (c) The aggregate principal amount of the Senior Preferred Notes that may be authenticated and delivered under
the Senior Preferred Debt Securities Indenture shall not exceed $1,250,000,000, except as otherwise provided in the Senior Preferred Debt Securities Indenture, including Section 2.01(t) hereof; 

(d) Principal on the Senior Preferred Notes shall be payable on March 24, 2025 (the “Maturity Date”); 

(e) The Senior Preferred Notes shall be issued in global registered form on March 24, 2022. From (and including) the date of issuance to
(and excluding) the Maturity Date, interest on the Senior Preferred Notes will be payable at a fixed rate of 3.496% per annum. Interest will be payable semi-annually in arrears on September 24 and March 24 of each year (each, an
“Interest Payment Date”), commencing September 24, 2022, up to and including the Maturity Date or any date of earlier redemption; 

Interest on the Senior Preferred Notes will be calculated on the basis of a 360-day year divided into
twelve months of 30 days each and, in the case of an incomplete month, the actual number of days elapsed in such month. The regular record date for the Senior Preferred Notes will be 15 calendar days immediately preceding the relevant Interest
Payment Date, whether or not a Business Day (the “Regular Record Date”); 
 (f) No premium, upon redemption or otherwise,
shall be payable by the Company on the Senior Preferred Notes; 
 (g) Principal of and any interest on the Senior Preferred Notes shall be
paid to the Holder through The Bank of New York Mellon, as paying agent of the Company having offices in London, United Kingdom and the Borough of Manhattan, The City of New York; 

(h) The Senior Preferred Notes shall not be redeemable except as provided in Article 11 of the Senior Preferred Debt Securities Indenture, as
amended by this Second Supplemental Indenture; 
 (i) The Company shall have no obligation to redeem or purchase the Senior Preferred Notes
pursuant to any sinking fund or analogous provision; 

  
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 (j) The Senior Preferred Notes shall be issued only in minimum denominations of $200,000 and
integral multiples of $200,000 in excess thereof; 
 (k) The principal amount of the Senior Preferred Notes shall be payable, subject to the
conditions set forth in Section 3.07 hereto, upon the declaration of acceleration thereof pursuant to Section 5.02 of the Base Indenture, as amended by Section 3.07 hereto; 

(l) Additional Amounts in respect of the Senior Preferred Notes shall be payable as set forth in the Senior Preferred Debt Securities
Indenture; 
 (m) The Senior Preferred Notes shall be denominated in, and payments thereon shall be made in, U.S. Dollars only; 

(n) The payment of principal of or interest, if any, on the Senior Preferred Notes shall be payable only in the coin or currency in which the
Senior Preferred Notes are denominated; 
 (o) The Senior Preferred Notes will be issued in the form of one or more global securities in
registered form, without coupons attached, and initially registered in the name of Cede & Co., as nominee of The Depository Trust Company, the Depositary; 

(p) The Senior Preferred Notes will not be initially issued in definitive form; 

(q) The Events of Default on the Senior Preferred Notes are as provided for in the Senior Preferred Debt Securities Indenture; 

(r) The Company agrees with respect to the Senior Preferred Notes and each Holder of the Senior Preferred Notes, by his or her acquisition of
the Senior Preferred Notes will be deemed to have agreed to the ranking as described in Section 2.02 of the Senior Preferred Debt Securities Indenture. Each such Holder will be deemed to have irrevocably waived his or her rights of priority
which would otherwise be accorded to him or her under the laws of Spain, to the extent necessary to effectuate the ranking provisions of the Senior Preferred Notes. In addition, each Holder of the Senior Preferred Notes by his or her acquisition of
such Senior Preferred Notes authorizes and directs the Trustee on his or her behalf to take such action as may be necessary or appropriate to effectuate the ranking of such Senior Preferred Notes as provided in the Senior Preferred Debt Securities
Indenture, and appoints the Trustee as his or her attorney-in-fact for any and all such purposes; 

(s) The form of the Senior Preferred Notes to be issued on the date hereof shall be substantially in the form of Exhibit A hereto; 

  
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 (t) The Company may issue additional Senior Preferred Notes (“Additional
Senior Preferred Notes”) after the date hereof having the same ranking and same interest rate, maturity date, redemption terms and other terms, except for the price to the public, original interest accrual date, issue date
and first Interest Payment Date, as the Senior Preferred Notes; provided, however, that such Additional Senior Preferred Notes will not have the same CUSIP, ISIN or other identifying number as the outstanding Senior Preferred Notes unless the
Additional Senior Preferred Notes are fungible with the Senior Preferred Notes for U.S. federal income tax purposes. Any such Additional Senior Preferred Notes, together with the Senior Preferred Notes, will constitute a single series of securities
under the Senior Preferred Debt Securities Indenture; 
 (u) The Company appoints The Bank of New York Mellon, London Branch, as the
Principal Paying Agent for the Senior Preferred Notes; 
 (v) The Company appoints The Bank of New York Mellon SA/NV, Luxembourg Branch, as
the Senior Preferred Debt Securities Registrar for the Senior Preferred Notes pursuant to Section 3.05 of the Base Indenture; 
 (w) If
(i) a TLAC/MREL Disqualification Event or (ii) a tax event that would entitle the Company to redeem the Senior Preferred Notes as set forth in Section 11.08 of the Base Indenture, occurs and is continuing, the Company may substitute
all (but not some) of the Senior Preferred Notes or modify the terms of all (but not some) of the Senior Preferred Notes as provided for in Section 8.04 of the Senior Preferred Debt Securities Indenture; 

(x) Subject to applicable law, neither any Holder or beneficial owner of the Senior Preferred Notes nor the Trustee acting on behalf of the
Holders of the Senior Preferred Notes may exercise, claim or plead any right of set-off, netting, compensation or retention in respect of any amount owed to it by the Company in respect of, or arising under,
or in connection with, the Senior Preferred Notes as provided for in Section 5.15 of the Senior Preferred Debt Securities Indenture; 

(y) Each Holder of the Senior Preferred Notes acknowledges, accepts, consents to and agrees to be bound by the effect of the exercise of the Bail-in Power by the Relevant Resolution Authority as provided for in Article 12 of the Senior Preferred Debt Securities Indenture; and 

(z) The Bank of New York Mellon SA/NV, Luxembourg Branch, as the Senior Preferred Debt Securities Registrar for the Senior Preferred Notes
acknowledges, accepts, consents to and agrees to be bound by the effect of the exercise of the Bail-in Power by the Relevant Resolution Authority as provided for in Article 12 of the Senior Preferred Debt
Securities Indenture. 
 ARTICLE 3 

ADDITIONAL TERMS APPLICABLE TO THE SENIOR PREFERRED NOTES 

Section 3.01. Addition of Definitions. With respect to the Senior Preferred Notes only, Section 1.01 of the Base Indenture is
amended to include the following definitions (which shall be deemed to arise in Section 1.01 in their proper alphabetical order): 

“Additional Senior Preferred Notes” shall have the meaning provided in Section 2.01(t) hereof. 

“Issue Date” means March 24, 2022, being the date of the initial issue of the Senior Preferred Notes. 

  
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 “Maturity Date” means March 24, 2025. 

“RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing Law 11/2015, as amended or superseded from time to
time. 
 Section. 3.02. [Reserved] 

Section 3.03. Replacement of Definitions. With respect to the Senior Preferred Notes only, Section 1.01 of the Base Indenture
is amended to replace in their entirety the following definitions: 
 “Applicable Banking Regulations” means
at any time the laws, regulations, requirements, guidelines and policies relating to capital adequacy, resolution and/or solvency including, among others, those giving effect to the MREL and the TLAC or any equivalent or successor principles, then
applicable to the Company and/or the Group including, without limitation to the generality of the foregoing, the CRD IV, the BRRD, the SRM Regulation and those regulations, requirements, guidelines and policies relating to capital adequacy,
resolution and/or solvency of the Regulator then applicable to the Company and/or the Group including, among others, those giving effect to the MREL and the TLAC or any equivalent or successor principles, in each case to the extent then in effect in
the Kingdom of Spain (whether or not such regulations, requirements, guidelines or policies have the force of law and whether or not they are applied generally or specifically to the Company and/or the Group). 

“Business Day” means any day, other than Saturday or Sunday, that is not a Legal Holiday nor a day on which
banking institutions are authorized or required by law, regulation or executive order to close in the City of New York or London nor a day when the Trans-European Automated Real-time Gross Settlement Express Transfer system (the “TARGET2
System”), or any successor thereto, is closed for business. 
 “CRR” means Regulation (EU)
No. 575/2013 of the European Parliament and of the Council of 26 June 2013 on the prudential requirements for credit institutions and investment firms and amending Regulation (EU) No. 648/2012 or such other regulation as may come into
effect in place thereof, as amended from time to time. 

  
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 “Qualifying Notes” means, with respect to each series of
Senior Preferred Debt Securities, at any time, any securities issued directly by the Company that have terms not otherwise materially less favorable to the Holders of the Senior Preferred Debt Securities of such series than the terms of the Senior
Preferred Debt Securities of such series, provided that such securities shall: 
 (i) contain terms which comply with the
then current requirements for TLAC/MREL Eligible Instruments as embodied in the Applicable Banking Regulations; 
 (ii) carry
the same rate of interest as the Senior Preferred Debt Securities of such series prior to the relevant substitution or variation pursuant to Section 8.04; 

(iii) have the same denomination and aggregate outstanding principal amount as the Senior Preferred Debt Securities of such
series prior to the relevant substitution or variation pursuant to Section 8.04; 
 (iv) have the same date of maturity
and the same dates for payment of interest as the Senior Preferred Debt Securities of such series prior to the relevant substitution or variation pursuant to Section 8.04; 

(v) have at least the same ranking as the Senior Preferred Debt Securities of such series; 

(vi) not, immediately following such substitution or variation, be subject to (i) a TLAC/MREL Disqualification Event
and/or (ii) a tax event that would entitle the Company to redeem the Senior Preferred Debt Securities of such series as set forth under Section 11.08; and 

(vii) be listed or admitted to trading on any stock exchange as selected by the Company, if the Senior Preferred Debt
Securities of such series were listed or admitted to trading on a stock exchange immediately prior to the relevant substitution or variation pursuant to Section 8.04. 

“Regular Record Date” means the date that is 15 calendar days immediately preceding the relevant Interest
Payment Date, whether or not a Business Day. 
 “SRM Regulation” means Regulation (EU) No. 806/2014 of
the European Parliament and of the Council of 15 July 2014, establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment firms in the framework of the Single Resolution Mechanism and the
Single Resolution Fund and amending Regulation (EU) No. 1093/2010, as amended or replaced from time to time. 

  
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 “Supervisory Permission” means, in relation to any action,
such supervisory permission (or, as appropriate, waiver) from the Regulator as is required therefor under Applicable Banking Regulations. 

A “TLAC/MREL Disqualification Event” shall have occurred at any time that all or part of the outstanding
nominal amount of a series of Senior Preferred Debt Securities does not fully qualify as TLAC/MREL Eligible Instruments of the Company and/or the Group, except where such non-qualification (i) is due
solely to the remaining maturity of the Senior Preferred Debt Securities of such series being less than any period prescribed for TLAC/MREL Eligible Instruments by the Applicable Banking Regulations as at the issue date of the relevant series of
Senior Preferred Debt Securities or (ii) is as a result of the Senior Preferred Debt Securities of such series being bought back by or on behalf of the Company or a buy back of the Senior Preferred Debt Securities of such series which is funded
by or on behalf of the Company. 
 Section 3.04. Payment. Notwithstanding Section 3.07 of the Base Indenture, payments of
interest, if any, and any Additional Amounts on the Senior Preferred Notes may be made by wire transfer of immediately available funds. 

Section 3.05. Deletion of Satisfaction and Discharge Provisions. With respect to the Senior Preferred Notes only, Article 4 of the
Base Indenture is deleted in its entirety. 
 Section 3.06. Replacement of Provisions with Respect to Events of Default. With
respect to the Senior Preferred Notes only, Section 5.01(a) of the Base Indenture is hereby replaced with the following: 

Except as otherwise provided pursuant to Section 3.01, if any of the following events occurs and is continuing with
respect to the Senior Preferred Debt Securities of any series, it shall constitute an “Event of Default”: 
 (i)
Non-payment: default is made in the payment of any interest or principal due in respect of the Senior Preferred Debt Securities of that series or any of them and such default continues for a
period of seven days (or such other period as may be specified pursuant to Section 3.01); or 
 (ii) Winding up:
any order is made by any competent court or resolution passed for the winding up or liquidation of the Company (except in any such case for the purpose of reconstruction or amalgamation or a merger,
spin-off or any other structural modification (modificación estructural), provided that any entity that survives or is created as a result of such merger,
spin-off or other structural modification is given a rating by an internationally recognized rating agency at least equal to the then current rating of the Company at the time of such transaction). 

  
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 Section 3.07. Replacement of Provisions with Respect to Acceleration of
Maturity; Rescission and Annulment. With respect to the Senior Preferred Notes only, Section 5.02 of the Base Indenture is hereby replaced with the following: 

Enforcement of Remedies. (a) If an Event of Default occurs as set forth in paragraph (a)(i) of
Section 5.01, then the Trustee or the Holders of at least 25% in outstanding principal amount of the Senior Preferred Debt Securities of that series may institute proceedings for the winding up or liquidation of the Company but may take no
further action in respect of such default. 
 If an Event of Default occurs as set forth in paragraph (a)(ii) of
Section 5.01, then the Trustee or the Holders of at least 25% in outstanding principal amount of the Senior Preferred Debt Securities of that series may declare such Senior Preferred Debt Securities of such series immediately due and payable
whereupon the Senior Preferred Debt Securities of such series shall, when permitted by applicable Spanish insolvency law, become immediately due and payable at their Early Termination Amount together with all interest (if any) accrued thereon. 

Without prejudice to paragraphs (a)(i) and (a)(ii) of Section 5.01, the Trustee or the holders of at least 25% in
outstanding principal amount of the Senior Preferred Debt Securities of any series may at their discretion and without further notice, institute such proceedings against the Company as they may think fit to enforce any obligation, condition or
provision binding on the Company under the Senior Preferred Debt Securities of such series, provided that, except as provided in Section 5.01(a)(ii) winding-up above, the Company shall not as a consequence of
such proceedings be obliged to pay any sum or sums representing or measured by reference to principal or interest in respect of the Senior Preferred Debt Securities of such series sooner than the same would otherwise have been payable by it or any
damages. 
 Section 3.08. Replacement of Provisions with Respect to Waiver of Right of
Set-off. With respect to the Senior Preferred Notes only, Section 5.15 of the Base Indenture is hereby replaced with the following: 

Waiver of Right of Set-off. Subject to applicable law, neither any Holder
or beneficial owner of the Senior Preferred Debt Securities of any series, nor the Trustee acting on behalf of the Holders of the Senior Preferred Debt Securities of such series may exercise, claim or plead any right of set-off, netting, compensation or retention in respect of any amount owed to it by the Company in respect of, or arising under, or in connection with, the Senior Preferred Debt Securities of such series or this
Senior Preferred Debt Securities Indenture and each Holder and beneficial owner of the Senior Preferred Debt Securities of such series, by virtue of its holding of any Senior Preferred Debt Securities of such series or any 

  
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interest therein, and the Trustee acting on behalf of the Holders of the Senior Preferred Debt Securities of such series, shall be deemed to have waived all such rights of set-off, netting, compensation or retention. If, notwithstanding the above, any amounts due and payable to any Holder or beneficial owner of a Senior Preferred Debt Security of any series, or any interest therein by
the Company in respect of, or arising under, the Senior Preferred Debt Securities of such series are discharged by set-off, such Holder or beneficial owner shall, subject to applicable law, immediately pay an
amount equal to the amount of such discharge to the Company (or, if the event of any voluntary or involuntary liquidation of the Company shall have occurred, the liquidator or administrator of the Company, as the case may be) and, until such time as
payment is made, shall hold an amount equal to such amount in trust (where possible) or otherwise for the Company (or the liquidator or administrator of the Company, as the case may be) and, accordingly, any such discharge shall be deemed not to
have taken place. 
 Section 3.09. Replacement of Provisions with Respect to Substitution and Variation. With respect to
the Senior Preferred Notes only, the first paragraph of Section 8.04 of the Base Indenture is hereby replaced with the following: 

Substitution and Variation. If (i) a TLAC/MREL Disqualification Event or (ii) a tax event that would
entitle the Company to redeem the Senior Preferred Debt Securities of such series as set forth in Section 11.08, occurs and is continuing, the Company may substitute all (but not some) of the Senior Preferred Debt Securities of such series or modify
the terms of all (but not some) of the Senior Preferred Debt Securities of such series, without any requirement for the consent or approval of the holders of the Senior Preferred Debt Securities of such series, so that they are substituted for, or
varied to, become, or remain, Qualifying Notes, subject to having given not less than 15 nor more than 30 days’ notice to the Holders of such series in accordance with Section 1.06 and to the Trustee (which notice shall be irrevocable and
shall specify the date for substitution or, as applicable, variation), and subject to obtaining Supervisory Permission therefor, if and as required under Applicable Banking Regulations. 

Section 3.10. Deletion of Provisions with Respect to Selection by the Trustee of Senior Preferred Debt Securities to Be
Redeemed. With respect to the Senior Preferred Notes only, the first paragraph of Section 11.03 of the Base Indenture is deleted in its entirety. 

  
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 Section 3.11. Replacement of Provisions with Respect to Optional Redemption for
Taxation Reasons. With respect to the Senior Preferred Notes only, Section 11.08 of the Base Indenture is hereby replaced with the following: 

Optional Redemption for Taxation Reasons. If (i) as a result of any change in, or amendment to, the laws or
regulations of Spain or of any political subdivision thereof or any authority or agency therein or thereof having power to tax or in the interpretation or administration of any such laws or regulations which becomes effective on or after the date of
issue of the first issued Senior Preferred Debt Securities of such series, the Company shall determine that (a) the Company would be required to pay Additional Amounts pursuant to Section 10.04 or (b) the Company would not be entitled
to claim a deduction in computing tax liabilities in Spain in respect of any interest to be paid on the next interest payment date on such series of Senior Preferred Debt Securities or the value of such deduction to the Company would be materially
reduced or (c) the applicable tax treatment of the Senior Preferred Debt Securities of such series changes in a material way that was not reasonably foreseeable at the issue date and (ii) such circumstances are evidenced by the delivery by the
Company to the Trustee of a copy of the Supervisory Permission for the redemption, if and as required, the Company may, at its option and having given no less than 15 nor more than 30 days’ notice to the Holders of the Senior Preferred Debt
Securities of such series in accordance with Section 11.04 (which notice shall be irrevocable) and a concurrent copy thereof to the Trustee, redeem in whole, but not in part, the Outstanding Senior Preferred Debt Securities of such series (in
accordance with the requirements of Applicable Banking Regulations in force at the relevant time) at their early tax redemption amount (the “Early Redemption Amount (Tax)”) (which shall be their principal amount), together with any
accrued interest thereon to (but excluding) the date fixed for redemption; provided, however, that (i) in the case of (i)(a) above, no such notice of redemption may be given earlier than 90 days prior to the earliest date on which the Company would
be obliged to pay such Additional Amounts were a payment in respect of the Senior Preferred Debt Securities of such series then due and (ii) redemption due to changes in tax treatment pursuant to this Section 11.08 may only take place in
accordance with Applicable Banking Regulations in force at the relevant time and subject to the Company obtaining Supervisory Permission therefor, if and as required. 

Section 3.12. Replacement of Provisions with Respect to Repurchase of Senior Preferred Debt Securities. With respect to the
Senior Preferred Notes only, Section 11.09 of the Base Indenture is hereby replaced with the following: 

Repurchase of Senior Preferred Debt Securities. The Company and any of its subsidiaries or any third party
designated by any of them, may at any time repurchase Senior Preferred Debt Securities of any series in the open market or otherwise and at any price; provided that the repurchase of the Senior Preferred Debt Securities of such series by the
Company or any of its subsidiaries shall take place in accordance with Applicable Banking Regulations in force at the relevant time and will be subject to the prior consent of the Regulator and/or the Relevant Resolution Authority, if and as
required. 

  
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 Section 3.13. Deletion of Provisions with Respect to Optional Early Redemption
(Call). With respect to the Senior Preferred Notes only, Section 11.10 of the Base Indenture is deleted in its entirety. 

Section 3.14. Deletion of Provisions with Respect to Optional Early Redemption (Put). With respect to the Senior Preferred
Notes only, Section 11.11 of the Base Indenture is deleted in its entirety. 
 Section 3.15. Deletion of Provisions with
Respect to Optional Redemption for TLAC/MREL Disqualification Event. With respect to the Senior Preferred Notes only, Section 11.12 of the Base Indenture is deleted in its entirety. 

ARTICLE 4 
 MISCELLANEOUS 

Section 4.01. Effect of Supplemental Indenture. Upon the execution and delivery of this Second Supplemental Indenture by each of
the Company and the Trustee, the Base Indenture shall be supplemented in accordance herewith, and this Second Supplemental Indenture shall form a part of the Base Indenture for all purposes in respect of the Senior Preferred Notes or otherwise as
applicable. 
 Section 4.02. Confirmation of Indenture. The Senior Preferred Debt Securities Indenture, with respect to the
Senior Preferred Notes or otherwise as applicable, is in all respects ratified and confirmed, and the Base Indenture, this Second Supplemental Indenture and all indentures supplemental thereto shall, in respect of the Senior Preferred Notes or
otherwise as applicable, be read, taken and construed as one and the same instrument. This Second Supplemental Indenture constitutes an integral part of the Senior Preferred Debt Securities Indenture and, where applicable, with respect to the Senior
Preferred Notes. In the event of a conflict between the terms and conditions of the Base Indenture and the terms and conditions of this Second Supplemental Indenture, the terms and conditions of this Second Supplemental Indenture shall prevail where
applicable. 
 Section 4.03. Concerning the Trustee. The Trustee does not make any representations as to the validity,
sufficiency or adequacy of this Second Supplemental Indenture or the Senior Preferred Notes. The recitals and statements herein and in the Senior Preferred Notes are deemed to be those of the Company and not the Trustee. In entering into this Second
Supplemental Indenture, the Trustee shall be entitled to the benefit of every provision of the Base Indenture relating to the conduct of or affecting the liability of or affording protection to the Trustee. 

  
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 Section 4.04. Governing Law. The Senior Preferred Debt Securities Indenture and
the Senior Preferred Notes shall be governed by and construed in accordance with the laws of the State of New York (without giving effect to the choice of law provisions), except for Section 2.02 of the Senior Preferred Debt Securities
Indenture, Section 2.01(r) of this Second Supplemental Indenture and the status provisions of the Senior Preferred Notes, which shall be governed by and construed in accordance with the laws of the Kingdom of Spain, and except that the
authorization and execution by the Company of the Senior Preferred Debt Securities Indenture and the Senior Preferred Notes shall be governed by (in addition to the laws of the State of New York relevant to execution) the respective jurisdictions of
organization of the Company and the Trustee, as the case may be. 
 Section 4.05. Separability. In case any provision contained
in this Second Supplemental Indenture shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

Section 4.06. Counterparts. This Second Supplemental Indenture may be executed in any number of counterparts, each of which so
executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument. The exchange of copies of this Second Supplemental Indenture and of signature pages by facsimile, e-mail or other electronic format (e.g., PDF, “tif” or “jpg”) transmission and other electronically imaged signatures (including, without limitation, DocuSign and AdobeSign) shall constitute
effective execution and delivery of this Second Supplemental Indenture as to the parties hereto and may be used in lieu of the original Second Supplemental Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile, e-mail or other electronic format (e.g., PDF, “tif” or “jpg”) shall be deemed to be their original signatures for all purposes. This Second Supplemental Indenture and any indenture supplemental
hereto and any other document, certificate or opinion delivered in connection with this Second Supplemental Indenture, such supplemental indenture or the issuance and delivery of the Senior Preferred Debt Securities may be signed by or on behalf of
the Company and the Trustee by manual, facsimile or pdf or other electronically imaged signature (including, without limitation, DocuSign and AdobeSign). 

Section 4.07. Electronic Means. The Trustee shall have the right to accept and act upon instructions, including funds transfer
instructions (“Instructions”) given pursuant to this Second Supplemental Indenture and related financing documents and delivered using e-mail, facsimile transmission, secure electronic
transmission containing applicable authorization codes, passwords and/or authentication keys issued by the Trustee, or another method or system specified by the Trustee as available for use in connection with its services hereunder (collectively,
the “Electronic Means”); provided, however, that the Company shall provide to the Trustee an incumbency certificate listing officers with the authority to provide such Instructions (“Authorized Officers”) and
containing specimen signatures of such Authorized Officers, which incumbency certificate shall be amended by the Company whenever a person is to be added or deleted from the listing. If the Company elects to give the Trustee Instructions using
Electronic Means and the Trustee in its discretion elects to act upon such Instructions, the Trustee’s understanding of such Instructions shall be deemed controlling. The Company understands and agrees that the Trustee cannot determine the
identity of the actual sender of such Instructions and that the Trustee shall conclusively presume that directions that 

  
 13 

 
purport to have been sent by an Authorized Officer listed on the incumbency certificate provided to the Trustee have been sent by such Authorized Officer. The Company shall be responsible for
ensuring that only Authorized Officers transmit such Instructions to the Trustee and that the Company and all Authorized Officers are solely responsible to safeguard the use and confidentiality of applicable user and authorization codes, passwords
and/or authentication keys upon receipt by the Company. The Trustee shall not be liable for any losses, costs or expenses arising directly or indirectly from the Trustee’s reliance upon and compliance with such Instructions notwithstanding such
directions conflict or are inconsistent with a subsequent written instruction. The Company agrees: (i) to assume all risks arising out of the use of Electronic Means to submit Instructions to the Trustee, including without limitation the risk
of the Trustee acting on unauthorized Instructions, and the risk of interception and misuse by third parties; (ii) that it is fully informed of the protections and risks associated with the various methods of transmitting Instructions to the
Trustee and that there may be more secure methods of transmitting Instructions than the method(s) selected by the Company; (iii) that the security procedures (if any) to be followed in connection with its transmission of Instructions provide to it a
commercially reasonable degree of protection in light of its particular needs and circumstances; and (iv) to notify the Trustee immediately upon learning of any compromise or unauthorized use of the security procedures. 

Section 4.08. Recognition of Bail-In. Notwithstanding and to the exclusion of any other
term of this Second Supplemental Indenture or any other agreements, arrangements, or understanding between the Senior Preferred Debt Securities Registrar and the Company or any Holder, the Company and each Holder acknowledges and accepts that a BRRD
Liability arising under this Second Supplemental Indenture may be subject to the exercise of Bail-in Powers by the Relevant Resolution Authority, and acknowledges, accepts, and agrees to be bound by: 

(a) the effect of the exercise of Bail-in Powers by the Relevant Resolution Authority in relation to
any BRRD Liability of the Senior Preferred Debt Securities Registrar to the Company or to any Holder under this Second Supplemental Indenture, that (without limitation) may include and result in any of the following, or some combination thereof:

 (i) the reduction of all, or a portion, of the BRRD Liability or outstanding amounts due thereon; 

(ii) the conversion of all, or a portion, of the BRRD Liability into shares, other securities or other obligations of the
Senior Preferred Debt Securities Registrar or another person, and the issue to or conferral on the Company or on any Holder of such shares, securities or obligations; 

(iii) the cancellation of the BRRD Liability; 

(iv) the amendment or alteration of any interest, if applicable, thereon, the maturity or the dates on which any payments are
due, including by suspending payment for a temporary period; 

  
 14 

 (b) the variation of the terms of this Second Supplemental Indenture, as deemed necessary by
the Relevant Resolution Authority, to give effect to the exercise of Bail-in Powers by the Relevant Resolution Authority in respect of the Senior Preferred Debt Securities Registrar. 

Solely as used in this Section 4.08: 

“Bail-in Legislation” means in relation to a member state of the European Economic Area which
has implemented, or which at any time implements, the BRRD, the relevant implementing law, regulation, rule or requirement as described in the EU Bail-in Legislation Schedule from time to time. 

“Bail-in Powers” means any Write-down and Conversion Powers as defined in the EU Bail-in Legislation Schedule, in relation to the relevant Bail-in Legislation. 

“BRRD” means Directive 2014/59/EU establishing a framework for the recovery and resolution of credit institutions and investment
firms or such other directive as may amend or come into effect in place thereof, as amended or replaced from time to time and including any other relevant implementing regulatory provisions. 

“BRRD Liability” means a liability in respect of which the relevant Write-down and Conversion Powers in the applicable Bail-in Legislation may be exercised. 
 “EU Bail-in
Legislation Schedule” means the document described as such, then in effect, and published by the Loan Market Association (or any successor person) from time to time at http://www.lma.eu.com/pages.aspx?p=499. 

“Relevant Resolution Authority” means the resolution authority with the ability to exercise any
Bail-in Powers in relation to the Senior Preferred Debt Securities Registrar. 
 [Signature Pages
Follow] 

  
 15 

 IN WITNESS WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be duly executed as
of the date first written above. 
  

			
	BANCO SANTANDER, S.A., as Issuer
		
	By:	 	 /s/ Juan Urigoen Irusta

		 	Name: Juan Urigoen Irusta
		 	Title: Authorized Signatory

  
 [Signature Page to
Second Supplemental Indenture] 

 
			
	THE BANK OF NEW YORK MELLON,
	London Branch, as Trustee
		
	By:	 	 /s/ Thomas Bolton

		 	Name: Thomas Bolton
		 	Title:   Vice President

  
 [Signature Page to
Second Supplemental Indenture] 

 
			
	THE BANK OF NEW YORK MELLON SA/NV, Luxembourg Branch, as Registrar
		
	By:	 	 /s/ Thomas Bolton

		 	Name: Thomas Bolton
		 	Title:   Vice President

  
 [Signature Page to
Second Supplemental Indenture] 

 EXHIBIT A 

FORM OF GLOBAL NOTE 
 THIS NOTE IS A
GLOBAL SECURITY AND IS REGISTERED IN THE NAME OF THE DEPOSITORY TRUST COMPANY AS THE DEPOSITARY (AS DEFINED IN THE SENIOR PREFERRED DEBT SECURITIES INDENTURE GOVERNING THIS NOTE), OR ITS NOMINEE IN CUSTODY FOR THE BENEFIT OF THE BENEFICIAL OWNERS
HEREOF, AND IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (I) THE TRUSTEE MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO THE BASE INDENTURE, (II) THIS GLOBAL NOTE MAY BE EXCHANGED IN WHOLE BUT NOT IN
PART PURSUANT TO SECTION 3.05 OF THE BASE INDENTURE, (III) THIS GLOBAL NOTE MAY BE DELIVERED TO THE TRUSTEE FOR CANCELLATION PURSUANT TO SECTION 3.09 OF THE BASE INDENTURE AND (IV) THIS GLOBAL NOTE MAY BE TRANSFERRED TO A SUCCESSOR
DEPOSITARY WITH THE PRIOR WRITTEN CONSENT OF THE COMPANY. UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SENIOR PREFERRED NOTES IN DEFINITIVE FORM, THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE
DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. UNLESS THIS GLOBAL SECURITY IS
PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITARY TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY GLOBAL SECURITY ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS MAY BE
REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITARY (AND ANY PAYMENT IS MADE TO CEDE & CO. OR SUCH OTHER ENTITY AS MAY BE REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITARY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR
VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 THE RANKING OF
THIS NOTE IS SET FORTH IN SECTION 2.02 OF THE SENIOR PREFERRED DEBT SECURITIES INDENTURE, AND SECTION 2.01(r) OF THE SECOND SUPPLEMENTAL INDENTURE, AND THIS NOTE IS ISSUED SUBJECT TO THE PROVISIONS OF SUCH SECTIONS 2.02 AND 2.01(r), RESPECTIVELY,
AND THE HOLDER OF THIS NOTE, BY ACCEPTING THE SAME, AGREES TO AND SHALL BE BOUND BY SUCH PROVISIONS. THE PROVISIONS OF SECTION 2.02 OF THE SENIOR PREFERRED DEBT SECURITIES INDENTURE, SECTION 2.01(r) OF THE SECOND SUPPLEMENTAL INDENTURE AND THE TERMS
OF THIS PARAGRAPH ARE GOVERNED BY, AND SHALL BE CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE KINGDOM OF SPAIN. 

 CUSIP No. 05964H AP0 

ISIN No. US05964HAP01 
 SERIES 140
3.496% SENIOR PREFERRED FIXED RATE NOTES DUE 2025 
 Issued by 

BANCO SANTANDER, S.A. 
  

			
	No.	  	$

 BANCO SANTANDER, S.A., a sociedad anónima, incorporated under the laws of the Kingdom of Spain (herein called the
“Company”, which term includes any successor person under the Senior Preferred Debt Securities Indenture (as defined on the reverse hereof)), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the
principal sum of $                 (                 dollars) on March 24, 2025 (the
“Maturity Date”) or on such earlier date as the principal hereof may become due in accordance with the terms hereof and to pay interest thereon semi-annually in arrears on September 24 and March 24 of each year, commencing on
September 24, 2022, and ending the Maturity Date (each, an “Interest Payment Date”). Interest so payable on any Interest Payment Date shall be paid to the Holder in whose name this Note is registered at the close of business on the
15th calendar day immediately preceding the relevant Interest Payment Date, whether or not such day is a Business Day, as defined in the Senior Preferred Debt Securities Indenture (each a “Regular Record Date”). 

From (and including) the date of issuance to (and excluding) the Maturity Date, interest on this Note will be payable at a fixed rate of
3.496% per annum. 
 Payments of interest on this Note shall be computed on the basis of a 360-day
year divided into twelve months of 30 days each and, in the case of an incomplete month, the actual number of days elapsed in such month. 

Payment of the principal amount of and any interest on, this Note will be made by wire transfer of immediately available funds in such coin or
currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. Such payment shall be made to the Holder including through a Paying Agent of the Company for collection by the Holder. If the
date for payment of the principal amount hereof or interest thereon is not a Business Day, then (subject as provided in the Senior Preferred Debt Securities Indenture) such payment shall be made on the next succeeding Business Day with the same
force and effect as if made on such date for payment, provided that no interest shall accrue on such payment for the period from and after such payment date. 

The Senior Preferred Notes are issuable in minimum denominations of $200,000 and integral multiples of $200,000 in excess thereof. 

  
 A-2 

 For information purposes only, without any substantive effect whatsoever and solely in order
to comply with Article 413(d) of the Spanish Companies Law (Ley de Sociedades de Capital), approved by Royal Decree 1/2010, of July 2, to the extent applicable, it is hereby noted that the initial aggregate principal amount
of the Senior Preferred Notes, i.e., US $1,250,000,000 was equivalent to approximately €1,132,759,401.90, at the Bloomberg reference exchange rate as of March 21, 2022 of US $1.1035 per €1.00. Amounts due on the Notes shall not under
any circumstances whatsoever be payable in any currency other than U.S. Dollars. 
 Prior to due presentment of this Note for registration
of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Note is registered as the owner of such Note for the purpose of receiving payment of principal and interest, if any, on and any
Additional Amounts with respect to such Note and for all other purposes whatsoever, whether or not such Note be overdue, and neither the Company, the Trustee nor any agent of the Company or the Trustee shall be affected by notice to the contrary.

 Reference is hereby made to the further provisions of this Note set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been executed by or on
behalf of the Trustee referred to on the reverse hereof by manual, PDF or other electronically imaged signature (including, without limitation, DocuSign and AdobeSign), this Note shall not be entitled to any benefit under the Senior Preferred Debt
Securities Indenture or be valid or obligatory for any purpose. 
 Notwithstanding any other term of this Note or any other agreements,
arrangements, or understandings between the Company and any Holder of the Senior Preferred Notes, by its acquisition of this Note, each Holder (which includes each holder of a beneficial interest in this Note) acknowledges, accepts, consents to and
agrees: (i) to be bound by the effect of the exercise of the Bail-in Power by the Relevant Resolution Authority, which may include and result in any of the following, or some combination thereof: the
reduction of all, or a portion, of the Amounts Due on a permanent basis; the conversion of all, or a portion, of the Amounts Due into Common Equity Tier 1 instruments, other securities or other obligations of the Company or another person (and the
issue to the Holder of such Common Equity Tier 1 instruments, securities or obligations), including by means of an amendment, modification or variation of the terms of the Senior Preferred Notes, in which case the Holder agrees to accept in lieu of
its rights under this Note, any such Common Equity Tier 1 instruments, other securities or other obligations of the Company or another person; the cancellation of this Note or Amounts Due; the amendment or alteration of the maturity of this Note or
amendment of the interest payable on this Note, or the date on which the interest becomes payable, including by suspending payment for a temporary period; and (ii) that the terms of this Note are subject to, and may be varied, if necessary, to
give effect to, the exercise of the Bail-in Power by the Relevant Resolution Authority: 

“Amounts Due” means the principal amount of, premium, if any, together with any accrued but unpaid interest, and Additional Amounts,
if any, due on the Senior Preferred Notes. References to such amounts will include amounts that have become due and payable, but which have not been paid, prior to the exercise of the Bail-in Power by the
Relevant Resolution Authority. 

  
 A-3 

 “Bail-in Power” means any power existing
from time to time under, and exercised in compliance with, any laws, regulations, rules or requirements in effect in the Kingdom of Spain, relating to (i) the transposition of the BRRD, and in particular its article 59 (including but not
limited to, Law 11/2015, RD 1012/2015 and any other implementing regulations), (ii) the SRM Regulation and (iii) the instruments, rules or standards created thereunder, pursuant to which any obligation of a Regulated Entity (or an affiliate of
such Regulated Entity) can be reduced, cancelled, suspended, modified, or converted into shares, other securities, or other obligations of such Regulated Entity (or affiliate of such Regulated Entity). 

“Business Day” means any day, other than Saturday or Sunday, that is not a Legal Holiday nor a day on which banking institutions are
authorized or required by law, regulation or executive order to close in the City of New York or London nor a day when the Trans-European Automated Real-time Gross Settlement Express Transfer system (the “TARGET2 System”), or any successor
thereto, is closed for business. 
 “BRRD” means Directive 2014/59/EU of 15 May establishing the framework for the recovery
and resolution of credit institutions and investment firms or such other directive as may amend or come into effect in place thereof, as implemented into law by Law 11/2015 and RD 1012/2015, as amended or replaced from time to time and including any
other relevant implementing regulatory provisions. 
 “Law 11/2015” means Law 11/2015 of 18 June, on recovery and resolution
of credit institutions and investment firms (Ley 11/2015, de 18 de junio, de recuperación y resolución de entidades de crédito y empresas de servicios de inversión) as amended or replaced from time
to time. 
 “RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing Law 11/2015, as amended or
superseded from time to time. 
 “Regulated Entity” means any entity to which BRRD, as implemented in the Kingdom of Spain
(including but not limited to, Law 11/2015, RD 1012/2015 and any other implementing regulations), or any other Spanish law relating to the Bail-in Power, applies, which includes, certain credit institutions,
investment firms, and certain of their parent or holding companies. 
 “Relevant Resolution Authority” means the Spanish Fund for
the Orderly Restructuring of Banks, the Bank of Spain, the European Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the Bail-in Power
or any other resolution power from time to time. 
 “SRM Regulation” means Regulation (EU) No. 806/2014 of the European
Parliament and of the Council of 15 July 2014, establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment firms in the framework of the Single Resolution Mechanism and the Single
Resolution Fund and amending Regulation (EU) No. 1093/2010, as amended or replaced from time to time. 
 The public deed of issuance
(escritura de emisión) related to the Senior Preferred Notes represented hereby was executed on March 22, 2022 before Mr. Miguel Ruiz Gallardón García de la Rasilla with the number 2,029 of his records. 

  
 A-4 

 IN WITNESS WHEREOF, the Company has caused this Note to be duly executed. 

Dated: 
  

			
	BANCO SANTANDER, S.A., as Issuer
		
	By:	 	          

		 	Name:
		 	Title:

 [Global Note Signature Page] 

  
 A-5 

 CERTIFICATE OF AUTHENTICATION 

This is one of the Senior Preferred Debt Securities of the series designated herein referred to in the within-mentioned Senior Preferred Debt
Securities Indenture. 
 Dated: 
  

			
	THE BANK OF NEW YORK MELLON,
	London Branch, as Trustee
		
	By:	 	          

		 	Name:
		 	Title:

 [Global Note Signature Page] 

  
 A-6 

 [REVERSE OF SECURITY] 

This Note is one of a duly authorized issue of securities of the Company of the series designated Series 140 3.496% Senior Preferred Fixed
Rate Notes due 2025 (herein called the “Senior Preferred Notes”) issued and to be issued in one or more series under a Senior Preferred Debt Securities Indenture, dated as of June 30, 2021, as heretofore supplemented and amended
(herein called the “Base Indenture”), between the Company, as issuer, and The Bank of New York Mellon, London Branch, as trustee (herein called the “Trustee”, which term includes any successor trustee under the Base Indenture),
as amended and supplemented by the Second Supplemental Indenture, dated as of March 24, 2022, among the Company, The Bank of New York Mellon, London Branch, as Trustee and Principal Paying Agent, and The Bank of New York Mellon SA/NV,
Luxembourg Branch, as Senior Preferred Debt Securities Registrar (the “Second Supplemental Indenture”, and, the Base Indenture, as amended and supplemented by the Second Supplemental Indenture, the “Senior Preferred Debt Securities
Indenture”) to which Senior Preferred Debt Securities Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company
and the Trustee and the Holders of the Senior Preferred Notes and of the terms upon which the Senior Preferred Notes are, and are to be, authenticated and delivered. Capitalized terms used herein are used as defined in the Senior Preferred Debt
Securities Indenture unless otherwise indicated. The terms of the Senior Preferred Notes include those stated in the Senior Preferred Debt Securities Indenture. The Senior Preferred Notes are subject to all such terms, and Holders are referred to
the Senior Preferred Debt Securities Indenture for a statement of all such terms. To the extent permitted by applicable law, in the event of any inconsistency between the terms of this Note and the terms of the Senior Preferred Debt Securities
Indenture, the terms of the Senior Preferred Debt Securities Indenture will control. 
 This Note is one of the series designated on the
face hereof, initially limited in aggregate principal amount to $1,250,000,000; provided, that the Company may, from time to time, without the consent of the Holders of the Senior Preferred Notes, issue additional Senior Preferred Debt
Securities under the Senior Preferred Debt Securities Indenture, having the same ranking and same interest rate, maturity, redemption terms and other terms, except for the price to the public, original interest accrual date, issue date and first
interest payment date, as the Senior Preferred Notes; provided, however, that such additional Senior Preferred Notes will not have the same CUSIP, ISIN or other identifying number as the outstanding Senior Preferred Notes unless the
additional Senior Preferred Notes are fungible with the Senior Preferred Notes for U.S. federal income tax purposes. Any such additional Senior Preferred Notes, together with the Senior Preferred Notes, will constitute a single series of Senior
Preferred Notes under the Senior Preferred Debt Securities Indenture and shall be included in the definition of “Senior Preferred Debt Securities” in the Base Indenture where the context requires. 

The payment obligations of the Company under the Senior Preferred Notes on account of principal constitute direct, unconditional,
unsubordinated and unsecured obligations (créditos ordinarios) of the Company and, upon the insolvency of Banco Santander (but subject to any other ranking that may apply as a result of any mandatory provision of law (or
otherwise)), such payment obligations in respect of principal rank (i) pari passu among themselves and with any Senior Higher Priority Liabilities (as defined below) and (ii) senior to (x) any Senior Non Preferred Liabilities
(as defined below) and (y) any present and future subordinated obligations (créditos subordinados) of the Company in accordance with Article 281 of the Spanish Insolvency Law (as defined below). 

  
 A-7 

 Claims of Holders of Senior Preferred Notes in respect of interest accrued but unpaid as
of the commencement of any insolvency procedure in respect of the Company shall constitute subordinated claims (créditos subordinados) against the Company ranking in accordance with the provisions of Article 281.1.3o of the
Spanish Insolvency Law and no further interest shall accrue from the date of the declaration of insolvency of the Company. 
 The
obligations of the Company under the Senior Preferred Notes are subject to the Bail-in Power. 

“Law 11/2015” means Law 11/2015 of 18 June, on recovery and resolution of credit institutions and investment firms (Ley
11/2015, de 18 de junio, de recuperación y resolución de entidades de crédito y empresas de servicios de inversión) as amended or replaced from time to time. 

“Senior Higher Priority Liabilities” means the unsubordinated and unsecured obligations (créditos ordinarios) of the
Company (including the Senior Preferred Notes), other than the Senior Non Preferred Liabilities. 
 “Senior Non Preferred
Liabilities” means any unsubordinated and unsecured senior non preferred obligations (créditos ordinarios no preferentes) of the Company under Additional Provision 14.2 of Law 11/2015 (including senior non preferred notes) and any
other obligations which, by law and/or by their terms, and to the extent permitted by Spanish law, rank pari passu with the Senior Non Preferred Liabilities. 

“Spanish Insolvency Law” means the restated text of the Spanish Insolvency Law (Ley Concursal) approved by the Royal
Decree-Legislative 1/2020, of 5 May, as amended from time to time. 
 The provisions of Section 2.02 of the Senior
Preferred Debt Securities Indenture, and Section 2.01(r) of the Second Supplemental Indenture shall apply only to rights or claims payable with respect to the Senior Preferred Notes and nothing herein shall affect or prejudice the payment of
the costs, charges, expenses, liabilities, indemnity or remuneration of the Trustee, the first lien rights of the Trustee under Section 6.08 of the Base Indenture, or the rights and remedies of the Trustee in respect thereof. 

The Company agrees with respect to the Senior Preferred Notes and each Holder of the Senior Preferred Notes, by his or her acquisition of the
Senior Preferred Notes will be deemed to have agreed to the ranking as described herein. Each such Holder will be deemed to have irrevocably waived his or her rights of priority which would otherwise be accorded to him or her under the laws of
Spain, to the extent necessary to effectuate the ranking provisions of the Senior Preferred Notes. In addition, each Holder of the Senior Preferred Notes by his or her acquisition of such Senior Preferred Notes authorizes and directs the Trustee on
his or her behalf to take such action as may be necessary or appropriate to effectuate the ranking of such Senior Preferred Notes as provided in the Senior Preferred Debt Securities Indenture, and as summarized herein and appoints the Trustee as his
or her attorney-in-fact for any and all such purposes. 

  
 A-8 

 Notwithstanding any other term of this Note or any other agreements, arrangements, or
understandings between the Company and any Holder of the Senior Preferred Notes, by its acquisition of this Note, each Holder (which includes each holder of a beneficial interest in this Note) acknowledges, accepts, consents to and agrees:
(i) to be bound by the effect of the exercise of the Bail-in Power by the Relevant Resolution Authority, which may include and result in any of the following, or some combination thereof: the reduction of
all, or a portion, of the Amounts Due on a permanent basis; the conversion of all, or a portion, of the Amounts Due into Common Equity Tier 1 instruments, other securities or other obligations of the Company or another person (and the issue to the
Holder of such Common Equity Tier 1 instruments, securities or obligations), including by means of an amendment, modification or variation of the terms of the Senior Preferred Notes, in which case the Holder agrees to accept in lieu of its rights
under this Note, any such Common Equity Tier 1 instruments, other securities or other obligations of the Company or another person; the cancellation of this Note or Amounts Due; the amendment or alteration of the maturity of this Note or amendment
of the interest payable on this Note, or the date on which the interest becomes payable, including by suspending payment for a temporary period; and (ii) that the terms of this Note are subject to, and may be varied, if necessary, to give
effect to, the exercise of the Bail-in Power by the Relevant Resolution Authority. 
 “Amounts
Due” means the principal amount of, premium, if any, together with any accrued but unpaid interest, and Additional Amounts, if any, due on the Senior Preferred Notes. References to such amounts will include amounts that have become due and
payable, but which have not been paid, prior to the exercise of the Bail-in Power by the Relevant Resolution Authority. 

“Bail-in Power” means any power existing from time to time under, and exercised in
compliance with, any laws, regulations, rules or requirements in effect in the Kingdom of Spain, relating to (i) the transposition of the BRRD, and in particular its article 59 (including but not limited to, Law 11/2015, RD 1012/2015 and any
other implementing regulations), (ii) the SRM Regulation and (iii) the instruments, rules or standards created thereunder, pursuant to which any obligation of a Regulated Entity (or an affiliate of such Regulated Entity) can be reduced,
cancelled, suspended, modified, or converted into shares, other securities, or other obligations of such Regulated Entity (or affiliate of such Regulated Entity). 

“BRRD” means Directive 2014/59/EU of 15 May establishing the framework for the recovery and resolution of credit institutions
and investment firms or such other directive as may amend or come into effect in place thereof, as implemented into law by Law 11/2015 and RD 1012/2015, as amended or replaced from time to time and including any other relevant implementing
regulatory provisions. 
 “RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing Law 11/2015, as amended or
superseded from time to time. 
 “Regulated Entity” means any entity to which BRRD, as implemented in the Kingdom of Spain
(including but not limited to, Law 11/2015, RD 1012/2015 and any other implementing regulations), or any other Spanish law relating to the Bail-in Power, applies, which includes, certain credit institutions,
investment firms, and certain of their parent or holding companies. 

  
 A-9 

 “Relevant Resolution Authority” means the Spanish Fund for the Orderly
Restructuring of Banks, the Bank of Spain, the European Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the Bail-in Power or any other
resolution power from time to time. 
 “SRM Regulation” means Regulation (EU) No. 806/2014 of the European Parliament and of
the Council of 15 July 2014, establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment firms in the framework of the Single Resolution Mechanism and the Single Resolution Fund and
amending Regulation (EU) No. 1093/2010, as amended or replaced from time to time. 
 The exercise of the
Bail-in Power by the Relevant Resolution Authority with respect to the Senior Preferred Notes shall not constitute an event of default and the terms and conditions of the Senior Preferred Notes shall continue
to apply in relation to the residual principal amount of, or outstanding amount payable with respect to, the Senior Preferred Notes subject to any modification of the amount of distributions payable to reflect the reduction of the principal amount,
and any further modification of the terms that the Relevant Resolution Authority may decide in accordance with applicable laws and regulations relating to the resolution of credit institutions, investment firms and/or Company entities incorporated
in the relevant member state. 
 No repayment or payment of Amounts Due, if any, on the Senior Preferred Notes, will become due and payable
or be paid after the exercise of any Bail-in Power by the Relevant Resolution Authority if and to the extent such amounts have been reduced, converted, cancelled, amended or altered as a result of such
exercise. 
 By its acquisition of this Note, each Holder of this Note, (which, for the purposes of this clause, includes each Holder of a
beneficial interest in this Note), to the extent permitted by the Trust Indenture Act, will waive any and all claims, in law and/or in equity, against the Trustee for, agree not to initiate a suit against the Trustee in respect of, and agree that
the Trustee will not be liable for, any action that the Trustee takes, or abstains from taking, in either case in accordance with the exercise of the Bail-in Power by the Relevant Resolution Authority with
respect to this Note. 
 Additionally, by its acquisition of this Note, each Holder of this Note acknowledges and agrees that, upon the
exercise of the Bail-in Power by the Relevant Resolution Authority: 
 (i) the Trustee will not be
required to take any further directions from the Holders of the Senior Preferred Notes with respect to any portion of the Senior Preferred Notes that are written-down, converted to equity and/or cancelled under the Senior Preferred Debt Securities
Indenture, which authorizes Holders of a majority in aggregate outstanding principal amount of the outstanding Senior Preferred Notes to direct certain actions relating to the Senior Preferred Notes; and 

(ii) the Senior Preferred Debt Securities Indenture will not impose any duties upon the Trustee whatsoever with respect to the exercise of the Bail-in Power by the Relevant Resolution Authority; 
 provided, however, that notwithstanding the
exercise of the Bail-in Power by the Relevant Resolution Authority, so long as the Senior Preferred Notes remain outstanding, there will at all times be a Trustee for the Senior Preferred Notes in
accordance with the Senior Preferred Debt Securities Indenture, and the resignation and/or removal of the Trustee and the appointment of a successor Trustee will continue to be governed by the Base Indenture, including to the extent no additional
supplemental indenture or amendment is agreed upon in the event the Senior Preferred Notes remain outstanding following the completion of the exercise of the Bail-in Power. 

  
 A-10 

 By its acquisition of this Note, each Holder of this Note acknowledges and agrees that
neither a cancellation or deemed cancellation of the principal or interest (in each case, in whole or in part), nor the exercise of the Bail-in Power by the Relevant Resolution Authority with respect to the
Senior Preferred Notes will give rise to a default for purposes of Section 315(b) (Notice of Default) and Section 315(c) (Duties of the Trustee in Case of Default) of the Trust Indenture Act. 

By purchasing this Note, each Holder (including each beneficial owner) of this Note shall be deemed to have authorized, directed and requested
DTC and any direct participant in DTC or other intermediary through which it holds this Note to take any and all necessary action, if required, to implement the exercise of the Bail-in Power with respect to
the Senior Preferred Notes as it may be imposed, without any further action or direction on the part of such Holder. 
 Each Holder of this
Note also acknowledges and agrees that the foregoing description of the Bail-in Power and its exercise is exhaustive on the matters described herein to the exclusion of any other agreements, arrangements or
understandings relating to the application of any Bail-in Power to the Senior Preferred Notes. 

Each Holder of this Note that acquires such Senior Preferred Notes in the secondary market (including each beneficial owner) shall be deemed
to acknowledge, agree to be bound by and consent to the same provisions specified herein to the same extent as the Holders of the Senior Preferred Notes that acquire the Senior Preferred Notes upon their initial issuance, including, without
limitation, with respect to the acknowledgment and agreement to be bound by and consent to the terms of the Senior Preferred Notes, including in relation to the
Bail-in-Power. 
 Additional terms of the Senior Preferred
Notes, including but not limited to events of default, remedies, payment of additional amounts in respect of withholding tax, substitution and variation of the Senior Preferred Notes upon certain regulatory events and amendment are set forth in the
Senior Preferred Debt Securities Indenture. 
 The Senior Preferred Debt Securities Indenture and the Senior Preferred Notes shall be
governed by and construed in accordance with the laws of the State of New York (without giving effect to the choice of law provisions), except for Section 2.02 of the Senior Preferred Debt Securities Indenture, Section 2.01(r) of the
Second Supplemental Indenture and the status of the Senior Preferred Notes, which shall be governed by and construed in accordance with the laws of The Kingdom of Spain, and except that the authorization and execution by the Company of the Senior
Preferred Debt Securities Indenture and the Senior Preferred Notes shall be governed by (in addition to the laws of the State of New York relevant to execution) the respective jurisdictions of organization of the Company and the Trustee, as the case
may be. 
 The Senior Preferred Notes and this Note have been issued in the State of New York. 

  
 A-11EX-4.2

 Exhibit 4.2 

 
  

BANCO SANTANDER, S.A. 
 as
Issuer, 
 THE BANK OF NEW YORK MELLON, 

London Branch 
 as Trustee,
Calculation Agent and Principal Paying Agent 
 and 

THE BANK OF NEW YORK MELLON SA/NV, 

Luxembourg Branch 
 as
Senior Non Preferred Debt Securities Registrar 
  

 
 FOURTH
SUPPLEMENTAL INDENTURE 
 dated as of March 24, 2022 

to 
 SENIOR NON PREFERRED DEBT
SECURITIES INDENTURE 
 dated as of May 28, 2020 
  

 

 FOURTH SUPPLEMENTAL INDENTURE (“Fourth Supplemental Indenture”), dated as
of March 24, 2022, among BANCO SANTANDER, S.A., a sociedad anónima incorporated under the laws of The Kingdom of Spain (the “Company”), having its principal executive office located at Ciudad Grupo Santander,
Avenida de Cantabria s/n, 28660 Boadilla del Monte, Madrid, Spain, as Issuer, THE BANK OF NEW YORK MELLON, London Branch, a banking corporation duly organized and existing under the laws of the State of New York, as trustee (the
“Trustee,” which term includes any successor Trustee), calculation agent (the “Calculation Agent,” which term includes any successor Calculation Agent) and principal paying agent (the “Principal Paying Agent,”
which term includes any successor Principal Paying Agent), having its Corporate Trust Office at One Canada Square, London, E14 5AL, United Kingdom and THE BANK OF NEW YORK MELLON SA/NV, Luxembourg Branch, a société anonyme/naamloze
vennootschap, incorporated under the laws of Belgium, as senior non preferred debt securities registrar (the “Senior Non Preferred Debt Securities Registrar”), having its principal office at 2-4 Rue Eugène Ruppert, L-2453
Luxembourg, Luxembourg. 
 WITNESSETH 

WHEREAS, the Company and the Trustee have executed and delivered a Senior Non Preferred Debt Securities Indenture dated as of May 28,
2020 (as heretofore supplemented and amended, the “Base Indenture” and, the Base Indenture, as supplemented and amended by this Fourth Supplemental Indenture, the “Senior Non Preferred Indenture”), to provide for
the issuance of the Company’s senior non preferred debt securities (the “Senior Non Preferred Debt Securities”), including the Senior Non Preferred Notes (as defined below). 

WHEREAS, Section 9.01(d) of the Base Indenture permits the Company and the Trustee to change or eliminate any provisions of the Base
Indenture without the consent of Holders, subject to certain conditions; 
 WHEREAS, Section 9.01(f) of the Base Indenture permits the
Company and the Trustee to enter into a supplemental indenture to establish the forms or terms of Senior Non Preferred Debt Securities of any series as permitted under Sections 2.01 and 3.01 of the Base Indenture without the consent of Holders; 

WHEREAS, there are no Outstanding Senior Non Preferred Debt Securities of any series created prior to the execution of this Fourth
Supplemental Indenture that are entitled to the benefit of the provisions set forth herein or that would be adversely affected by such provisions; 

WHEREAS, the Executive Committee of the Company has authorized the entry into this Fourth Supplemental Indenture and the establishment of the
Senior Non Preferred Notes (as defined below), as required by Section 9.01 of the Base Indenture; 

  
 1 

 WHEREAS, the parties hereto desire to establish a series of Senior Non Preferred Debt
Securities to be known as the Series 141 4.175% Senior Non Preferred Fixed-To-Fixed Rate Notes due 2028 (the “Senior Non Preferred Notes”) pursuant to Sections 2.01 and 3.01 of the Base Indenture. The Senior Non Preferred Notes may
be issued from time to time, and any Senior Non Preferred Notes issued as part of the series created herein will constitute a single series of Senior Non Preferred Debt Securities under the Senior Non Preferred Indenture and shall be included in the
definition of “Senior Non Preferred Notes” where the context requires; 
 WHEREAS, the Company has requested and hereby requests
that the Trustee execute and deliver this Fourth Supplemental Indenture and the Company has provided the Trustee with an Executive Committee Resolution authorizing the execution of this Fourth Supplemental Indenture; 

WHEREAS, all actions required by the Company to be taken in order to make this Fourth Supplemental Indenture a valid, binding and enforceable
instrument in accordance with its terms, have been taken and performed, and the execution and delivery of this Fourth Supplemental Indenture has been duly authorized in all respects; and 

WHEREAS, where indicated, this Fourth Supplemental Indenture shall amend and supplement the Base Indenture; and to the extent that the terms
of the Base Indenture are inconsistent with such provisions of this Fourth Supplemental Indenture, the terms of this Fourth Supplemental Indenture shall govern. 

NOW, THEREFORE, the Company and the Trustee mutually covenant and agree as follows: 

ARTICLE 1 
 DEFINITIONS 

Section 1.01. Definition of Terms. For all purposes of this Fourth Supplemental Indenture: 

(a) a term defined anywhere in this Fourth Supplemental Indenture has the same meaning throughout; 

(b) capitalized terms used herein but not otherwise defined shall have the meanings assigned to them in the Base Indenture; 

(c) the singular includes the plural and vice versa; 

(d) headings are for convenience of reference only and do not affect interpretation; and 

(e) for the purposes of this Fourth Supplemental Indenture and the Base Indenture, the term “series” shall mean a series of the
Senior Non Preferred Debt Securities. 

  
 2 

 ARTICLE 2 

FORM OF SENIOR NON PREFERRED NOTES 

Section 2.01. Terms of the Senior Non Preferred Notes. The following terms relating to the Senior Non Preferred Notes are hereby
established pursuant to Section 3.01 of the Base Indenture: 
 (a) The Senior Non Preferred Notes shall be designated as: the Series 141
4.175% Senior Non Preferred Fixed-to-Fixed Rate Notes due 2028; 
 (b) The price at which the Senior Non Preferred Notes shall be issued is
100.000% of the principal amount thereof; 
 (c) The aggregate principal amount of the Senior Non Preferred Notes that may be authenticated
and delivered under the Senior Non Preferred Indenture shall not exceed $1,500,000,000, except as otherwise provided in the Senior Non Preferred Indenture, including Section 2.01(t) hereof; 

(d) Principal on the Senior Non Preferred Notes shall be payable on March 24, 2028 (the “Maturity Date”); 

(e) The Senior Non Preferred Notes shall be issued in global registered form on March 24, 2022. From (and including) the date of issuance
to (and excluding) March 24, 2027 (the “Reset Date”), interest on this Note will be payable at a fixed rate of 4.175% per annum. From (and including) the Reset Date to (but excluding) the Maturity Date (the “Reset
Period”), interest on the Senior Non Preferred Notes will be payable at a fixed rate equal to the applicable U.S. Treasury Rate (as defined herein) as of the second Business Day preceding the Reset Date (the “Reset Determination
Date”), plus 2.000% per annum. Interest will be payable semi-annually in arrears on September 24 and March 24 of each year (each, an “Interest Payment Date”), commencing September 24, 2022, up to and
including the Maturity Date or any date of earlier redemption; 
 Interest on the Senior Non Preferred Notes will be calculated on the basis
of a 360-day year divided into twelve months of 30 days each and, in the case of an incomplete month, the actual number of days elapsed in such month. The regular record date for the Senior Non Preferred Notes will be 15 calendar days immediately
preceding the relevant Interest Payment Date, whether or not a Business Day (the “Regular Record Date”); 
 (f) No premium,
upon redemption or otherwise, shall be payable by the Company on the Senior Non Preferred Notes; 
 (g) Principal of and any interest on the
Senior Non Preferred Notes shall be paid to the Holder through The Bank of New York Mellon, as paying agent of the Company having offices in London, United Kingdom and the Borough of Manhattan, The City of New York; 

  
 3 

 (h) The Senior Non Preferred Notes shall not be redeemable except as provided in Article 11
of the Senior Non Preferred Indenture, as amended by this Fourth Supplemental Indenture; 
 (i) The Company shall have no obligation to
redeem or purchase the Senior Non Preferred Notes pursuant to any sinking fund or analogous provision; 
 (j) The Senior Non Preferred Notes
shall be issued only in minimum denominations of $200,000 and integral multiples of $200,000 in excess thereof; 
 (k) The principal amount
of the Senior Non Preferred Notes shall be payable, subject to the conditions set forth in Section 3.08 hereto, upon the declaration of acceleration thereof pursuant to Section 5.02 of the Base Indenture, as amended by Section 3.08
hereto; 
 (l) Additional Amounts in respect of the Senior Non Preferred Notes shall be payable as set forth in the Senior Non Preferred
Indenture; 
 (m) The Senior Non Preferred Notes shall be denominated in, and payments thereon shall be made in, U.S. Dollars only; 

(n) The payment of principal of or interest, if any, on the Senior Non Preferred Notes shall be payable only in the coin or currency in which
the Senior Non Preferred Notes are denominated; 
 (o) The Senior Non Preferred Notes will be issued in the form of one or more global
securities in registered form, without coupons attached, and initially registered in the name of Cede & Co., as nominee of The Depository Trust Company, the Depositary; 

(p) The Senior Non Preferred Notes will not be initially issued in definitive form; 

(q) The Events of Default on the Senior Non Preferred Notes are as provided for in the Senior Non Preferred Indenture; 

(r) The Company agrees with respect to the Senior Non Preferred Notes and each Holder of the Senior Non Preferred Notes, by his or her
acquisition of the Senior Non Preferred Notes will be deemed to have agreed to the ranking as described in Section 12.01 of the Senior Non Preferred Indenture. Each such Holder will be deemed to have irrevocably waived his or her rights of priority
which would otherwise be accorded to him or her under the laws of Spain, to the extent necessary to effectuate the ranking provisions of the Senior Non Preferred Notes. In addition, each Holder of the Senior Non Preferred Notes by his or her
acquisition of such Senior Non Preferred Notes authorizes and directs the Trustee on his or her behalf to take such action as may be necessary or appropriate to effectuate the ranking of such Senior Non Preferred Notes as provided in the Senior Non
Preferred Indenture, and appoints the Trustee as his or her attorney-in-fact for any and all such purposes; 

  
 4 

 (s) The form of the Senior Non Preferred Notes to be issued on the date hereof shall be
substantially in the form of Exhibit A hereto; 
 (t) The Company may issue additional Senior Non Preferred Notes (“Additional
Senior Non Preferred Notes”) after the date hereof having the same ranking and same interest rate, maturity date, redemption terms and other terms, except for the price to the public, original interest accrual date, issue date and first
Interest Payment Date, as the Senior Non Preferred Notes; provided, however, that such Additional Senior Non Preferred Notes will not have the same CUSIP, ISIN or other identifying number as the outstanding Senior Non Preferred Notes unless
the Additional Senior Non Preferred Notes are fungible with the Senior Non Preferred Notes for U.S. federal income tax purposes. Any such Additional Senior Non Preferred Notes, together with the Senior Non Preferred Notes, will constitute a single
series of securities under the Senior Non Preferred Indenture; 
 (u) The Company appoints The Bank of New York Mellon, London Branch, as the
initial Calculation Agent and Principal Paying Agent for the Senior Non Preferred Notes; 
 (v) The Company appoints The Bank of New York
Mellon SA/NV, Luxembourg Branch as the Senior Non Preferred Debt Securities Registrar for the Senior Non Preferred Notes pursuant to Section 3.05 of the Base Indenture; 

(w) If (i) a TLAC/MREL Disqualification Event or (ii) a tax event that would entitle the Company to redeem the Senior Non Preferred
Notes as set forth in Section 11.08 of the Base Indenture, occurs and is continuing, the Company may substitute all (but not some) of the Senior Non Preferred Notes or modify the terms of all (but not some) of the Senior Non Preferred Notes as
provided for in Section 8.04 of the Senior Non Preferred Indenture; 
 (x) Subject to applicable law, neither any Holder or beneficial
owner of the Senior Non Preferred Notes nor the Trustee acting on behalf of the Holders of the Senior Non Preferred Notes may exercise, claim or plead any right of set-off, netting, compensation or retention in respect of any amount owed to it by
the Company in respect of, or arising under, or in connection with, the Senior Non Preferred Notes as provided for in Section 12.04 of the Senior Non Preferred Indenture; 

(y) Each Holder of the Senior Non Preferred Notes acknowledges, accepts, consents to and agrees to be bound by the effect of the exercise of
the Bail-in Power by the Relevant Resolution Authority as provided for in Article 13 of the Senior Non Preferred Indenture; and 
 (z) The
Bank of New York Mellon SA/NV, Luxembourg Branch, as the Senior Non Preferred Debt Securities Registrar for the Senior Non Preferred Notes acknowledges, accepts, consents to and agrees to be bound by the effect of the exercise of the Bail-in Power
by the Relevant Resolution Authority as provided for in Article 13 of the Senior Non Preferred Indenture. 

  
 5 

 ARTICLE 3 

ADDITIONAL TERMS APPLICABLE TO THE SENIOR NON PREFERRED NOTES 

Section 3.01. Addition of Definitions. With respect to the Senior Non Preferred Notes only, Section 1.01 of the Base
Indenture is amended to include the following definitions (which shall be deemed to arise in Section 1.01 in their proper alphabetical order): 

“Additional Senior Non Preferred Notes” shall have the meaning provided in Section 2.01(t) hereof. 

“Comparable Treasury Issue” means, with respect to the Reset Period, the U.S. Treasury security or securities
selected by the Company (and notified to the Calculation Agent) with a maturity date on or about the last day of the Reset Period, and that would be utilized at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities denominated in U.S. dollars and having a maturity of one year. 
 “Comparable
Treasury Price” means, with respect to the Reset Date, (i) the arithmetic average of the Reference Treasury Dealer Quotations for the Reset Date (calculated on the Reset Determination Date preceding the Reset Date), after excluding the
highest and lowest such Reference Treasury Dealer Quotations, or (ii) if fewer than five such Reference Treasury Dealer Quotations are received, the arithmetic average of all such quotations, or (iii) if fewer than two such Reference
Treasury Dealer Quotations are received, then such Reference Treasury Dealer Quotation as quoted in writing to the Company and the Calculation Agent by a Reference Treasury Dealer. 

“H.15” means the daily statistical release designated as such and published by the Board of Governors of the
United States Federal Reserve System under the caption “Treasury constant maturities,” or any successor or replacement publication as determined by the Company (and notified to the Calculation Agent) that establishes yield on actively
traded U.S. Treasury securities adjusted to constant maturity, and “most recent H.15” means, in respect of the Reset Period, the H.15 which includes a yield to maturity for U.S. Treasury securities with a maturity of one year published
closest in time but prior to the Reset Determination Date. 
 “Issue Date” means March 24, 2022, being
the date of the initial issue of the Senior Non Preferred Notes. 
 “Maturity Date” means March 24,
2028. 

  
 6 

 “Reference Treasury Dealer” each of up to five banks
selected by the Company, or the affiliates of such banks, which are (i) primary U.S. Treasury securities dealers, and their respective successors, or (ii) market makers in pricing corporate bond issues denominated in U.S. dollars. 

“Reference Treasury Dealer Quotations” means with respect to each Reference Treasury Dealer and the Reset
Date, the arithmetic average, as determined by the Calculation Agent, of the bid and offered prices for the applicable Comparable Treasury Issue, expressed in each case as a percentage of its principal amount, at 11:00 a.m. (New York City time), on
the Reset Determination Date. 
 “RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing
Law 11/2015, as amended or superseded from time to time. 
 “Reset Date” means March 24, 2027. 

“Reset Determination Date” means the second Business Day preceding the Reset Date. 

“Reset Period” means the period from (and including) the Reset Date to (but excluding) the Maturity Date. 

“U.S. Treasury Rate” means, in relation to the Reset Date and the Reset Period commencing on the Reset Date,
the rate per annum equal to: (1) the average of the yields on actively traded U.S. Treasury securities adjusted to constant maturity, for one-year maturities, for the five Business Days immediately prior to the Reset Determination Date, published in
the most recent H.15, for the maturity of one year; or (2) if such release (or any successor release) is not published during the week immediately prior to the Reset Determination Date or does not contain such yields, the rate per annum equal
to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for the Reset
Date. 
 The U.S. Treasury Rate shall be determined by the Calculation Agent. 

If the U.S. Treasury Rate cannot be determined, for whatever reason, as described under (1) or (2) above, “U.S.
Treasury Rate” means the rate in percentage per annum as notified by the Calculation Agent to the Company equal to the yield on U.S. Treasury securities having a maturity of one year as set forth in the most recent H.15 (or any successor
release to be determined by the Company and notified to the Calculation Agent) at 5:00 p.m. (New York City time) on the Reset Determination Date. 

Section. 3.02. [Reserved] 

  
 7 

 Section 3.03. Replacement of Definitions. With respect to the Senior Non
Preferred Notes only, Section 1.01 of the Base Indenture is amended to replace in their entirety the following definitions: 

“Applicable Banking Regulations” means at any time the laws, regulations, requirements, guidelines and
policies relating to capital adequacy, resolution and/or solvency including, among others, those giving effect to the MREL and the TLAC or any equivalent or successor principles, then applicable to the Company and/or the Group including, without
limitation to the generality of the foregoing, the CRD IV, the BRRD, the SRM Regulation and those regulations, requirements, guidelines and policies relating to capital adequacy, resolution and/or solvency of the Regulator then applicable to the
Company and/or the Group including, among others, those giving effect to the MREL and the TLAC or any equivalent or successor principles, in each case to the extent then in effect in the Kingdom of Spain (whether or not such regulations,
requirements, guidelines or policies have the force of law and whether or not they are applied generally or specifically to the Company and/or the Group). 

“Bail-in Power” means any power existing from time to time under, and exercised in compliance with, any laws,
regulations, rules or requirements in effect in the Kingdom of Spain, relating to (i) the transposition of the BRRD, and in particular its article 59 (including but not limited to, Law 11/2015, RD 1012/2015 and any other implementing
regulations), (ii) the SRM Regulation and (iii) the instruments, rules or standards created thereunder, pursuant to which any obligation of a Regulated Entity (or an affiliate of such Regulated Entity) can be reduced, cancelled, suspended,
modified, or converted into shares, other securities, or other obligations of such Regulated Entity (or affiliate of such Regulated Entity). 

“Business Day” means any day, other than Saturday or Sunday, that is not a Legal Holiday nor a day on which
banking institutions are authorized or required by law, regulation or executive order to close in the City of New York or London nor a day when the Trans-European Automated Real-time Gross Settlement Express Transfer system (the “TARGET2
System”), or any successor thereto, is closed for business. 
 “CRR” means Regulation (EU)
No. 575/2013 of the European Parliament and of the Council of 26 June 2013 on the prudential requirements for credit institutions and investment firms and amending Regulation (EU) No. 648/2012 or such other regulation as may come into
effect in place thereof, as amended from time to time. 

  
 8 

 “Qualifying Notes” means, with respect to each series of
Senior Non Preferred Debt Securities, at any time, any securities issued directly by the Company that have terms not otherwise materially less favorable to the Holders of the Senior Non Preferred Debt Securities of such series than the terms of the
Senior Non Preferred Debt Securities of such series, provided that such securities shall: 
 (i) contain terms which comply
with the then current requirements for TLAC/MREL-Eligible Instruments as embodied in the Applicable Banking Regulations; 

(ii) carry the same rate of interest as the Senior Non Preferred Debt Securities of such series prior to the relevant
substitution or variation pursuant to Section 8.04; 
 (iii) have the same denomination and aggregate outstanding
principal amount as the Senior Non Preferred Debt Securities of such series prior to the relevant substitution or variation pursuant to Section 8.04; 

(iv) have the same date of maturity and the same dates for payment of interest as the Senior Non Preferred Debt Securities of
such series prior to the relevant substitution or variation pursuant to Section 8.04; 
 (v) have at least the same
ranking as the Senior Non Preferred Debt Securities of such series; 
 (vi) not, immediately following such substitution or
variation, be subject to (i) a TLAC/MREL Disqualification Event and/or (ii) a tax event that would entitle the Company to redeem the Senior Non Preferred Debt Securities of such series as set forth under Section 8.04; and 

(vii) be listed or admitted to trading on any stock exchange as selected by the Company, if the Senior Non Preferred Debt
Securities of such series were listed or admitted to trading on a stock exchange immediately prior to the relevant substitution or variation pursuant to Section 8.04. 

“Regulated Entity” means any entity to which BRRD, as implemented in the Kingdom of Spain (including but not
limited to, Law 11/2015, RD 1012/2015 and any other implementing regulations), or any other Spanish law relating to the Bail-in Power, applies, which includes, certain credit institutions, investment firms, and certain of their parent or holding
companies. 
 “Regular Record Date” means the date that is 15 calendar days immediately preceding the
relevant Interest Payment Date, whether or not a Business Day. 
 “Regulator” means the European Central
Bank, the Bank of Spain, the Relevant Resolution Authority or such other or successor authority exercising primary bank supervisory authority or the role of primary bank resolution authority, in each case with respect to prudential matters in
relation to the Company and/or the Group. 

  
 9 

 “Relevant Resolution Authority” means the Spanish Fund for
the Orderly Restructuring of Banks, the Bank of Spain, the European Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the Bail-in Power or any other resolution power from time
to time. 
 “Spanish Insolvency Law” means the restated text of the Spanish Insolvency Law (Ley
Concursal) approved by the Royal Decree-Legislative 1/2020, of 5 May, as amended from time to time. 
 “SRM
Regulation” means Regulation (EU) No. 806/2014 of the European Parliament and of the Council of 15 July 2014, establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment
firms in the framework of the Single Resolution Mechanism and the Single Resolution Fund and amending Regulation (EU) No. 1093/2010, as amended or replaced from time to time. 

“Supervisory Permission” means, in relation to any action, such supervisory permission (or, as appropriate,
waiver) from the Regulator as is required therefor under Applicable Banking Regulations. 
 A “TLAC/MREL
Disqualification Event” shall have occurred at any time that all or part of the outstanding nominal amount of a series of Senior Non Preferred Debt Securities does not fully qualify as TLAC/MREL Eligible Instruments of the Company and/or
the Group, except where such non-qualification (i) is due solely to the remaining maturity of the Senior Non Preferred Debt Securities of such series being less than any period prescribed for TLAC/MREL Eligible Instruments by the Applicable
Banking Regulations as at the issue date of the relevant series of Senior Non Preferred Debt Securities or (ii) is as a result of the Senior Non Preferred Debt Securities of such series being bought back by or on behalf of the Company or a buy
back of the Senior Non Preferred Debt Securities of such series which is funded by or on behalf of the Company. 
 Section 3.04.
[Reserved]. 
 Section 3.05. Payment. Notwithstanding Section 3.07 of the Base Indenture, payments of interest, if any, and
any Additional Amounts on the Senior Non Preferred Notes may be made by wire transfer of immediately available funds. 
 Section 3.06.
Deletion of Satisfaction and Discharge Provisions. With respect to the Senior Non Preferred Notes only, Article 4 of the Base Indenture is deleted in its entirety. 

  
 10 

 Section 3.07. Replacement of Provisions with Respect to Events of Default. With
respect to the Senior Non Preferred Notes only, Section 5.01(a)(ii) of the Base Indenture is hereby replaced with the following: 

Winding up: any order is made by any competent court or resolution passed for the winding up or liquidation of the
Company (except in any such case for the purpose of reconstruction or amalgamation or a merger, spin-off or any other structural modification (modificación estructural), provided that any entity that survives or is created as a result
of such merger, spin-off or other structural modification is given a rating by an internationally recognized rating agency at least equal to the then current rating of the Company at the time of such transaction). 

Section 3.08. Replacement of Provisions with Respect to Enforcement of Remedies. With respect to the Senior Non Preferred Notes
only, Section 5.02(a) of the Base Indenture is hereby replaced with the following: 
 If an Event of Default occurs as
set forth in paragraph (a)(i) of Section 5.01, then the Trustee or the Holders of at least 25% in outstanding principal amount of the Senior Non Preferred Debt Securities of that series may institute proceedings for the winding up or
liquidation of the Company but may take no further action in respect of such default. 
 Section 3.09. Collection of Indebtedness
and Suits for Enforcement by the Trustee. With respect to the Senior Non Preferred Notes only, Section 5.03 of the Base Indenture is amended in part to add the following sentences at the end of the section: 

No remedy against the Company other than as referred to in this Article 5 shall be available to the Holders, whether for the
recovery of amounts owing to the Holders in respect of the Senior Non Preferred Debt Securities or under this Senior Non Preferred Debt Securities Indenture or in respect of any breach by the Company of any of its other obligations under or in
respect of the Senior Non Preferred Debt Securities or under this Senior Non Preferred Debt Securities Indenture, except that the Holders shall have such rights and powers as they are required to have under the Trust Indenture Act. 

Section 3.10. Replacement of Provisions with Respect to Substitution and Variation. With respect to the Senior Non Preferred Notes
only, the first paragraph of Section 8.04 of the Base Indenture is hereby replaced with the following: 

Substitution and Variation. If (i) a TLAC/MREL Disqualification Event or (ii) a tax event that would entitle
the Company to redeem the Senior Non Preferred Debt Securities of any series as set forth in Section 11.08 occurs and is continuing, the Company may substitute all (but not some) of the Senior Non Preferred Debt Securities of any series or
modify the terms of all (but not some) of the Senior Non Preferred Debt Securities of such series, without any requirement for the consent or approval of the Holders of the Senior Non 

  
 11 

 Preferred Debt Securities of such series, so that they are substituted for, or varied to,
become, or remain, Qualifying Notes, subject to having given not less than 15 nor more than 30 days’ notice to the Holders of such series in accordance with Section 1.06 and to the Trustee (which notice shall be irrevocable and shall
specify the date for substitution or, as applicable, variation), and subject to obtaining Supervisory Permission therefor, if and as required under Applicable Banking Regulations. 

Section 3.11. Replacement of Provisions with Respect to Election to Redeem; Notice to Trustee. With respect to the Senior Non
Preferred Notes only, Section 11.02 of the Base Indenture is hereby replaced with the following: 
 Election to
Redeem; Notice to Trustee. The election of the Company to redeem any Senior Non Preferred Debt Securities shall be evidenced by a Board Resolution. The Company shall, at least 15 days prior, but not nor more than 30 days prior to the Redemption
Date fixed by the Company (unless a shorter notice shall be satisfactory to the Trustee), notify the Trustee of such Redemption Date, of the principal amount of Senior Non Preferred Debt Securities of such series to be redeemed and, if applicable,
the tenor of the Senior Non Preferred Debt Securities to be redeemed. In the case of any redemption of Senior Non Preferred Debt Securities of any series prior to the expiration of any provision restricting such redemption provided in the terms of
such Senior Non Preferred Debt Securities or elsewhere in this Senior Non Preferred Debt Securities Indenture, the Company shall furnish the Trustee with respect to such Senior Non Preferred Debt Securities with an Officer’s Certificate
evidencing compliance with or waiver of such provision. 
 Section 3.12. Deletion of Provisions with Respect to Selection by the
Trustee of Senior Non Preferred Debt Securities to Be Redeemed. With respect to the Senior Non Preferred Notes only, the first paragraph of Section 11.03 of the Base Indenture is deleted in its entirety. 

Section 3.13. Replacement of Provisions with Respect to Notice of Redemption. With respect to the Senior Non Preferred Notes only,
the first paragraph of Section 11.04 of the Base Indenture is hereby replaced with the following: 
 Notice of
Redemption. Notice of redemption shall be given not less than 15 days nor more than 30 days prior to the Redemption Date to each Holder of Senior Non Preferred Debt Securities to be redeemed in the manner and to the extent provided in
Section 1.06. 
 Section 3.14. Replacement of Provisions with Respect to Optional Redemption Due to Changes in Tax
Treatment. With respect to the Senior Non Preferred Notes only, Section 11.08 of the Base Indenture is hereby replaced with the following: 
  

  
 12 

 Optional Redemption Due to Changes in Tax Treatment. If (i) as a
result of any change in, or amendment to, the laws or regulations of Spain or of any political subdivision thereof or any authority or agency therein or thereof having power to tax or in the interpretation or administration of any such laws or
regulations which becomes effective on or after the date of issue of the first issued Senior Non Preferred Debt Securities of such series, the Company shall determine that (a) the Company would be required to pay Additional Amounts pursuant to
Section 10.04 or (b) the Company would not be entitled to claim a deduction in computing tax liabilities in Spain in respect of any interest to be paid on the next interest payment date on such series of Senior Non Preferred Debt
Securities or the value of such deduction to the Company would be materially reduced or (c) the applicable tax treatment of the Senior Non Preferred Debt Securities of such series changes in a material way that was not reasonably foreseeable at
the issue date and (ii) such circumstances are evidenced by the delivery by the Company to the Trustee of a copy of the Supervisory Permission for the redemption, if and as required, the Company may, at its option and having given no less than
15 nor more than 30 days’ notice to the Holders of the Senior Non Preferred Debt Securities of such series in accordance with Section 11.04 (which notice shall be irrevocable) and a concurrent copy thereof to the Trustee, redeem in whole,
but not in part, the Outstanding Senior Non Preferred Debt Securities of such series (in accordance with the requirements of Applicable Banking Regulations in force at the relevant time) at their early tax redemption amount (the “Early
Redemption Amount (Tax)”) (which shall be their principal amount), together with any accrued interest thereon to (but excluding) the date fixed for redemption; provided, however, that (i) in the case of (i)(a) above, no such notice of
redemption may be given earlier than 90 days prior to the earliest date on which the Company would be obliged to pay such Additional Amounts were a payment in respect of the Senior Non Preferred Debt Securities of such series then due and
(ii) redemption due to changes in tax treatment pursuant to this Section 11.08 may only take place in accordance with Applicable Banking Regulations in force at the relevant time and subject to the Company obtaining Supervisory Permission
therefor, if and as required. 
 Section 3.15. Replacement of Provisions with Respect to Optional Redemption For TLAC/MREL
Disqualification Event. With respect to the Senior Non Preferred Notes only, Section 11.09 of the Base Indenture is hereby replaced with the following: 

Optional Redemption For TLAC/MREL Disqualification Event. If, in relation to the Senior Non Preferred Debt Securities of
any series, a TLAC/MREL Disqualification Event has occurred and is continuing, then the Company may, at its option and having given not less than 15 nor more than 30 days’ notice to the Holders of the Senior Non Preferred Debt Securities of
such series in accordance with Section 11.04 above (which notice shall be irrevocable and shall specify the date for redemption) and a concurrent copy thereof to the Trustee, elect to redeem in whole but not in part the Outstanding Senior Non
Preferred Debt Securities of such series at their principal amount, together with any accrued and unpaid interest thereon to (but excluding) the date fixed for redemption (“Early Redemption Amount (TLAC/MREL Disqualification
Event)”). 

  
 13 

 Redemption for a TLAC/MREL Disqualification Event is subject to the Company
obtaining Supervisory Permission, if and as required under Applicable Banking Regulations, and may only take place in accordance with Applicable Banking Regulations in force at the relevant time. 

Section 3.16. Optional Early Redemption (Call). With respect to the Senior Non Preferred Notes only, Section 11.10 of the
Base Indenture is hereby replaced with the following: 
 Optional Early Redemption (Call). The Senior Non Preferred
Debt Securities may be redeemed at the Company’s option, in whole, but not in part, on the Reset Date, in accordance with the requirements of Applicable Banking Regulations in force at the relevant time and subject to the Company obtaining
Supervisory Permission therefor, if and as required, at a redemption price equal to 100% of the principal amount of the Senior Non Preferred Notes, plus accrued and unpaid interest thereon to, but excluding, the redemption date. The Company shall
give no less than 15 nor more than 30 days’ notice to the holders of the Senior Non Preferred Debt Securities to redeem such Senior Non Preferred Debt Securities. 

Section 3.17. Replacement of Provisions with Respect to Ranking of Senior Non Preferred Debt Securities. With respect to the
Senior Non Preferred Notes only, Section 12.01 of the Base Indenture is hereby replaced with the following: 

Ranking of Senior Non Preferred Debt Securities. The Company, for itself, its successors and assigns, covenants and
agrees, and each Holder of the Senior Non Preferred Debt Securities of any series by his acceptance thereof, likewise covenants and agrees, that the payment obligations of the Company under the Senior Non Preferred Debt Securities of such series on
account of principal constitute direct, unconditional, unsubordinated and unsecured senior non preferred obligations (créditos ordinarios no preferentes) of the Company and, in accordance with Additional Provision 14.2 of Law 11/2015,
but subject to any other ranking that may apply as a result of any mandatory provision of law (or otherwise), upon the insolvency of the Company, such payment obligations in respect of principal rank (i) pari passu among themselves and
with any Senior Non Preferred Liabilities, (ii) junior to the Senior Higher Priority Liabilities (and, accordingly, upon the insolvency of the Company, the claims in respect of principal under the Senior Non Preferred Debt Securities will be
met after payment in full of the Senior Higher Priority Liabilities) and (iii) senior to any present and future subordinated obligations (créditos subordinados) of the Company in accordance with Article 281 of the Spanish Insolvency
Law. 

  
 14 

 Claims of Holders of Senior Non Preferred Debt Securities of any series in
respect of interest accrued but unpaid as of the commencement of any insolvency procedure in respect of the Company shall constitute subordinated claims (créditos subordinados) against the Company ranking in accordance with the
provisions of Article 281.1.3o of the Spanish Insolvency Law and no further interest shall accrue from the date of the declaration of insolvency of the Company. 

The provisions of this Article 12 shall apply only to rights or claims payable under any Senior Non Preferred Debt Securities
of any series and nothing herein shall affect or prejudice the payment of the costs, charges, expenses, liabilities, indemnity or remuneration of the Trustee, the first lien rights of the Trustee under Section 6.08 hereof, or the rights and
remedies of the Trustee in respect thereof. 
 Section 3.18. Replacement of Provisions with Respect to Waiver of Right of Set-off.
With respect to the Senior Non Preferred Notes only, Section 12.04 of the Base Indenture is hereby replaced with the following: 

Waiver of Right of Set-off. Subject to applicable law, neither any Holder or beneficial owner of the Senior Non
Preferred Debt Securities of any series nor the Trustee acting on behalf of the Holders of the Senior Non Preferred Debt Securities of such series may exercise, claim or plead any right of set-off, netting, compensation or retention in respect of
any amount owed to it by the Company in respect of, or arising under, or in connection with, the Senior Non Preferred Debt Securities of such series or this Senior Non Preferred Debt Securities Indenture and each Holder and beneficial owner of the
Senior Non Preferred Debt Securities of such series, by virtue of its holding of any Senior Non Preferred Debt Securities of such series or any interest therein, and the Trustee acting on behalf of the Holders of the Senior Non Preferred Debt
Securities of such series, shall be deemed to have waived all such rights of set-off, netting, compensation or retention. If, notwithstanding the above, any amounts due and payable to any Holder or beneficial owner of a Senior Non Preferred Debt
Security of any series or any interest therein by the Company in respect of, or arising under, the Senior Non Preferred Debt Securities of such series are discharged by set-off, such Holder or beneficial owner shall, subject to applicable law,
immediately pay an amount equal to the amount of such discharge to the Company (or, if the event of any voluntary or involuntary liquidation of the Company shall have occurred, the liquidator or administrator of the Company, as the case may be) and,
until such time as payment is made, shall hold an amount equal to such amount in trust (where possible) or otherwise for the Company (or the liquidator or administrator of the Company, as the case may be) and, accordingly, any such discharge shall
be deemed not to have taken place. 

  
 15 

 Section 3.19. Replacement of Provisions with Respect to Agreement and
Acknowledgement with Respect to the Exercise of the Bail-in Power. With respect to the Senior Non Preferred Notes only, Section 13.01(a)(i) of the Base Indenture is hereby replaced with the following: 

 

	 	(i)	 to be bound by the effect of the exercise of the Bail-in Power by the Relevant Resolution Authority, which may
include and result in any of the following, or some combination thereof: 

  

	 	•	 	 the reduction of all, or a portion, of the Amounts Due on a permanent basis; 

 

	 	•	 	 the conversion of all, or a portion, of the Amounts Due into Common Equity Tier 1 instruments, other securities
or other obligations of the Company or another person (and the issue to the Holder of such Common Equity Tier 1 instruments, securities or obligations), including by means of an amendment, modification or variation of the terms of the Senior Non
Preferred Debt Securities, in which case the Holder agrees to accept in lieu of its rights under such Senior Non Preferred Debt Securities any such Common Equity Tier 1 instruments, other securities or other obligations of the Company or another
person; 

  

	 	•	 	 the cancellation of the Senior Non Preferred Debt Securities or Amounts Due; 

 

	 	•	 	 the amendment or alteration of the maturity of the Senior Non Preferred Debt Securities or amendment of the
interest payable on the Senior Non Preferred Debt Securities, or the date on which the interest becomes payable, including by suspending payment for a temporary period; and 

ARTICLE 4 
 MISCELLANEOUS 

Section 4.01. Effect of Supplemental Indenture. Upon the execution and delivery of this Fourth Supplemental Indenture by each of
the Company and the Trustee, the Base Indenture shall be supplemented in accordance herewith, and this Fourth Supplemental Indenture shall form a part of the Base Indenture for all purposes in respect of the Senior Non Preferred Notes or otherwise
as applicable. 
 Section 4.02. Confirmation of Indenture. The Senior Non Preferred Indenture with respect to the Senior Non
Preferred Notes or otherwise as applicable, is in all respects ratified and confirmed, and the Base Indenture, this Fourth Supplemental Indenture and all indentures supplemental thereto shall, in respect of the Senior Non Preferred Notes or
otherwise as applicable, be read, taken and construed as one and the same instrument. This Fourth Supplemental Indenture constitutes an integral part of the Senior Non Preferred Indenture and, where applicable, with respect to the Senior Non
Preferred Notes. In the event of a conflict between the terms and conditions of the Base Indenture and the terms and conditions of this Fourth Supplemental Indenture, the terms and conditions of this Fourth Supplemental Indenture shall prevail where
applicable. 

  
 16 

 Section 4.03. Concerning the Trustee. The Trustee does not make any
representations as to the validity, sufficiency or adequacy of this Fourth Supplemental Indenture or the Senior Non Preferred Notes. The recitals and statements herein and in the Senior Non Preferred Notes are deemed to be those of the Company and
not the Trustee. In entering into this Fourth Supplemental Indenture, the Trustee shall be entitled to the benefit of every provision of the Base Indenture relating to the conduct of or affecting the liability of or affording protection to the
Trustee. 
 Section 4.04. Governing Law. The Senior Non Preferred Indenture and the Senior Non Preferred Notes shall be governed
by and construed in accordance with the laws of the State of New York (without giving effect to the choice of law provisions), except for Section 12.01 of the Senior Non Preferred Indenture, Section 2.01(r) of this Fourth Supplemental
Indenture and the status provisions of the Senior Non Preferred Notes, which shall be governed by and construed in accordance with the laws of the Kingdom of Spain, and except that the authorization and execution by the Company of the Senior Non
Preferred Indenture and the Senior Non Preferred Notes shall be governed by (in addition to the laws of the State of New York relevant to execution) the respective jurisdictions of organization of the Company and the Trustee, as the case may be.

 Section 4.05. Separability. In case any provision contained in this Fourth Supplemental Indenture shall be invalid, illegal
or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

Section 4.06. Counterparts. This Fourth Supplemental Indenture may be executed in any number of counterparts, each of which so
executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument. The exchange of copies of this Fourth Supplemental Indenture and of signature pages by facsimile, e-mail or other
electronic format (e.g., “pdf”, “tif” or “jpg”) transmission and other electronically imaged signatures (including, without limitation, DocuSign and AdobeSign) shall constitute effective execution and delivery of this
Fourth Supplemental Indenture as to the parties hereto and may be used in lieu of the original Fourth Supplemental Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile, e-mail or other electronic format (e.g.,
“pdf” or “tif”) shall be deemed to be their original signatures for all purposes. This Fourth Supplemental Indenture and any indenture supplemental hereto and any other document, certificate or opinion delivered in connection
with this Fourth Supplemental Indenture, such supplemental indenture or the issuance and delivery of the Senior Non Preferred Debt Securities may be signed by or on behalf of the Company and the Trustee by manual, facsimile or pdf or other
electronically imaged signature (including, without limitation, DocuSign and AdobeSign). 

  
 17 

 Section 4.07. Electronic Means. The Trustee shall have the right to accept and
act upon instructions, including funds transfer instructions (“Instructions”) given pursuant to this Fourth Supplemental Indenture and related financing documents and delivered using e-mail, facsimile transmission, secure electronic
transmission containing applicable authorization codes, passwords and/or authentication keys issued by the Trustee, or another method or system specified by the Trustee as available for use in connection with its services hereunder (collectively,
the “Electronic Means”); provided, however, that the Company shall provide to the Trustee an incumbency certificate listing officers with the authority to provide such Instructions (“Authorized Officers”) and
containing specimen signatures of such Authorized Officers, which incumbency certificate shall be amended by the Company whenever a person is to be added or deleted from the listing. If the Company elects to give the Trustee Instructions using
Electronic Means and the Trustee in its discretion elects to act upon such Instructions, the Trustee’s understanding of such Instructions shall be deemed controlling. The Company understands and agrees that the Trustee cannot determine the
identity of the actual sender of such Instructions and that the Trustee shall conclusively presume that directions that purport to have been sent by an Authorized Officer listed on the incumbency certificate provided to the Trustee have been sent by
such Authorized Officer. The Company shall be responsible for ensuring that only Authorized Officers transmit such Instructions to the Trustee and that the Company and all Authorized Officers are solely responsible to safeguard the use and
confidentiality of applicable user and authorization codes, passwords and/or authentication keys upon receipt by the Company. The Trustee shall not be liable for any losses, costs or expenses arising directly or indirectly from the Trustee’s
reliance upon and compliance with such Instructions notwithstanding such directions conflict or are inconsistent with a subsequent written instruction. The Company agrees: (i) to assume all risks arising out of the use of Electronic Means to
submit Instructions to the Trustee, including without limitation the risk of the Trustee acting on unauthorized Instructions, and the risk of interception and misuse by third parties; (ii) that it is fully informed of the protections and risks
associated with the various methods of transmitting Instructions to the Trustee and that there may be more secure methods of transmitting Instructions than the method(s) selected by the Company; (iii) that the security procedures (if any) to be
followed in connection with its transmission of Instructions provide to it a commercially reasonable degree of protection in light of its particular needs and circumstances; and (iv) to notify the Trustee immediately upon learning of any
compromise or unauthorized use of the security procedures. 
 Section 4.08. Recognition of Bail-In. Notwithstanding and to the
exclusion of any other term of this Fourth Supplemental Indenture or any other agreements, arrangements, or understanding between the Senior Non Preferred Debt Securities Registrar and the Company or any Holder, the Company and each Holder
acknowledges and accepts that a BRRD Liability arising under this Fourth Supplemental Indenture may be subject to the exercise of Bail-in Powers by the Relevant Resolution Authority, and acknowledges, accepts, and agrees to be bound by: 

(a) the effect of the exercise of Bail-in Powers by the Relevant Resolution Authority in relation to any BRRD Liability of the Senior Non
Preferred Debt Securities Registrar to the Company or to any Holder under this Fourth Supplemental Indenture, that (without limitation) may include and result in any of the following, or some combination thereof: 

  
 18 

 (i) the reduction of all, or a portion, of the BRRD Liability or outstanding
amounts due thereon; 
 (ii) the conversion of all, or a portion, of the BRRD Liability into shares, other securities or
other obligations of the Senior Non Preferred Debt Securities Registrar or another person, and the issue to or conferral on the Company or on any Holder of such shares, securities or obligations; 

(iii) the cancellation of the BRRD Liability; 

(iv) the amendment or alteration of any interest, if applicable, thereon, the maturity or the dates on which any payments are
due, including by suspending payment for a temporary period; 
 (b) the variation of the terms of this Fourth Supplemental Indenture, as
deemed necessary by the Relevant Resolution Authority, to give effect to the exercise of Bail-in Powers by the Relevant Resolution Authority in respect of the Senior Non Preferred Debt Securities Registrar. 

Solely as used in this Section 4.08: 

“Bail-in Legislation” means in relation to a member state of the European Economic Area which has implemented, or which at any time
implements, the BRRD, the relevant implementing law, regulation, rule or requirement as described in the EU Bail-in Legislation Schedule from time to time. 

“Bail-in Powers” means any Write-down and Conversion Powers as defined in the EU Bail-in Legislation Schedule, in relation to the
relevant Bail-in Legislation. 
 “BRRD” means Directive 2014/59/EU establishing a framework for the recovery and resolution of
credit institutions and investment firms or such other directive as may amend or come into effect in place thereof, as amended or replaced from time to time and including any other relevant implementing regulatory provisions. 

“BRRD Liability” means a liability in respect of which the relevant Write-down and Conversion Powers in the applicable Bail-in
Legislation may be exercised. 
 “EU Bail-in Legislation Schedule” means the document described as such, then in effect, and
published by the Loan Market Association (or any successor person) from time to time at http://www.lma.eu.com/pages.aspx?p=499. 

“Relevant Resolution Authority” means the resolution authority with the ability to exercise any Bail-in Powers in relation to the
Senior Non Preferred Debt Securities Registrar. 
 [Signature Pages Follow] 

  
 19 

 IN WITNESS WHEREOF, the parties hereto have caused this Fourth Supplemental Indenture to be duly executed as
of the date first written above. 
  

			
	BANCO SANTANDER, S.A., as Issuer
		
	By:	 	 /s/ Juan Urigoen Irusta

	Name:	 	Juan Urigoen Irusta
	Title:	 	Authorized Signatory

 [Signature Page to Fourth Supplemental Indenture] 

 
			
	THE BANK OF NEW YORK MELLON, London Branch, as Trustee
		
	By:	 	 /s/ Thomas Bolton

	Name:	 	Thomas Bolton
	Title:	 	Vice President

 [Signature Page to Fourth Supplemental Indenture] 

 
			
	THE BANK OF NEW YORK MELLON SA/NV, Luxembourg Branch, as Registrar
		
	By:	 	 /s/ Thomas Bolton

	Name:	 	Thomas Bolton
	Title:	 	Vice President

 [Signature Page to Fourth Supplemental Indenture] 

 EXHIBIT A 

FORM OF GLOBAL NOTE 
 THIS NOTE IS A
GLOBAL SECURITY AND IS REGISTERED IN THE NAME OF THE DEPOSITORY TRUST COMPANY AS THE DEPOSITARY (AS DEFINED IN THE SENIOR NON PREFERRED INDENTURE GOVERNING THIS NOTE), OR ITS NOMINEE IN CUSTODY FOR THE BENEFIT OF THE BENEFICIAL OWNERS HEREOF, AND IS
NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (I) THE TRUSTEE MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO THE BASE INDENTURE, (II) THIS GLOBAL NOTE MAY BE EXCHANGED IN WHOLE BUT NOT IN PART PURSUANT TO
SECTION 3.05 OF THE BASE INDENTURE, (III) THIS GLOBAL NOTE MAY BE DELIVERED TO THE TRUSTEE FOR CANCELLATION PURSUANT TO SECTION 3.09 OF THE BASE INDENTURE AND (IV) THIS GLOBAL NOTE MAY BE TRANSFERRED TO A SUCCESSOR DEPOSITARY WITH THE PRIOR WRITTEN
CONSENT OF THE COMPANY. UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SENIOR NON PREFERRED NOTES IN DEFINITIVE FORM, THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF
THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. UNLESS THIS GLOBAL SECURITY IS PRESENTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITARY TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY GLOBAL SECURITY ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS MAY BE REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITARY (AND ANY PAYMENT IS MADE TO CEDE & CO. OR SUCH OTHER ENTITY AS MAY BE REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITARY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO
ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 THE RANKING OF THIS NOTE IS SET FORTH IN
SECTION 12.01 OF THE SENIOR NON PREFERRED INDENTURE, AND SECTION 2.01(r) OF THE FOURTH SUPPLEMENTAL INDENTURE, AND THIS NOTE IS ISSUED SUBJECT TO THE PROVISIONS OF SUCH SECTIONS 12.01 AND 2.01(r), RESPECTIVELY, AND THE HOLDER OF THIS NOTE, BY
ACCEPTING THE SAME, AGREES TO AND SHALL BE BOUND BY SUCH PROVISIONS. THE PROVISIONS OF SECTION 12.01 OF THE SENIOR NON PREFERRED INDENTURE, SECTION 2.01(r) OF THE FOURTH SUPPLEMENTAL INDENTURE AND THE TERMS OF THIS PARAGRAPH ARE GOVERNED BY, AND
SHALL BE CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE KINGDOM OF SPAIN. 

 CUSIP No. 05964H AQ8 

ISIN No. US05964HAQ83 
 SERIES 141
4.175% SENIOR NON PREFERRED FIXED-TO-FIXED RATE NOTES DUE 2028 
 Issued by 

BANCO SANTANDER, S.A. 
  

			
	No.	  	$

 BANCO SANTANDER, S.A., a sociedad anónima, incorporated under the laws of the Kingdom of Spain (herein called
the “Company”, which term includes any successor person under the Senior Non Preferred Indenture (as defined on the reverse hereof)), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the principal
sum of $             (             dollars) on March 24, 2028 (the “Maturity Date”) or on such earlier date as the
principal hereof may become due in accordance with the terms hereof and to pay interest thereon semi-annually in arrears on September 24 and March 24 of each year, commencing on September 24, 2022, and ending on the Maturity Date
(each, an “Interest Payment Date”). Interest so payable on any Interest Payment Date shall be paid to the Holder in whose name this Note is registered at the close of business on the 15th calendar day immediately preceding the relevant
Interest Payment Date, whether or not such day is a Business Day, as defined in the Senior Non Preferred Indenture (each a “Regular Record Date”). 

From (and including) the date of issuance to (and excluding) March 24, 2027 (the “Reset Date”), interest on this Note will be
payable at a fixed rate of 4.175% per annum. From (and including) the Reset Date to (but excluding) the Maturity Date (the “Reset Period”), interest on the Senior Non Preferred Notes will be payable at a fixed rate equal to the
applicable U.S. Treasury Rate as of the second Business Day preceding the Reset Date (the “Reset Determination Date”), plus 2.000% per annum. 

Payments of interest on this Note shall be computed on the basis of a 360-day year divided into twelve months of 30 days each and, in the case
of an incomplete month, the actual number of days elapsed in such month. 
 Payment of the principal amount of and any interest on, this
Note will be made by wire transfer of immediately available funds in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. Such payment shall be made to the Holder
including through a Paying Agent of the Company for collection by the Holder. If the date for payment of the principal amount hereof or interest thereon is not a Business Day, then (subject as provided in the Senior Non Preferred Indenture) such
payment shall be made on the next succeeding Business Day with the same force and effect as if made on such date for payment, provided that no interest shall accrue on such payment for the period from and after such payment date. 

  
 A-2 

 The Senior Non Preferred Notes are issuable in minimum denominations of $200,000 and
integral multiples of $200,000 in excess thereof. 
 For information purposes only, without any substantive effect whatsoever and solely in
order to comply with Article 413(d) of the Spanish Companies Law (Ley de Sociedades de Capital), approved by Royal Decree 1/2010, of July 2, to the extent applicable, it is hereby noted that the initial aggregate principal amount
of the Senior Non Preferred Notes, i.e., US$1,500,000,000, was equivalent to approximately €1,359,311,282.28, at the Bloomberg reference exchange rate as of March 21, 2022 of US $1.1035 per €1.00. Amounts due on the Notes shall not
under any circumstances whatsoever be payable in any currency other than U.S. Dollars. 
 Prior to due presentment of this Note for
registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Note is registered as the owner of such Note for the purpose of receiving payment of principal and interest, if
any, on and any Additional Amounts with respect to such Note and for all other purposes whatsoever, whether or not such Note be overdue, and neither the Company, the Trustee nor any agent of the Company or the Trustee shall be affected by notice to
the contrary. 
 Reference is hereby made to the further provisions of this Note set forth on the reverse hereof, which further provisions
shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been
executed by or on behalf of the Trustee referred to on the reverse hereof by manual, PDF or other electronically imaged signature (including, without limitation, DocuSign and AdobeSign), this Note shall not be entitled to any benefit under the
Senior Non Preferred Indenture or be valid or obligatory for any purpose. 
 Notwithstanding any other term of this Note or any other
agreements, arrangements, or understandings between the Company and any Holder of the Senior Non Preferred Notes, by its acquisition of this Note, each Holder (which includes each holder of a beneficial interest in this Note) acknowledges, accepts,
consents to and agrees: (i) to be bound by the effect of the exercise of the Bail-in Power by the Relevant Resolution Authority, which may include and result in any of the following, or some combination thereof: the reduction of all, or a
portion, of the Amounts Due on a permanent basis; the conversion of all, or a portion, of the Amounts Due into Common Equity Tier 1 instruments, other securities or other obligations of the Company or another person (and the issue to the Holder of
such Common Equity Tier 1 instruments, securities or obligations), including by means of an amendment, modification or variation of the terms of the Senior Non Preferred Notes, in which case the Holder agrees to accept in lieu of its rights under
this Note, any such Common Equity Tier 1 instruments, other securities or other obligations of the Company or another person; the cancellation of this Note or Amounts Due; the amendment or alteration of the maturity of this Note or amendment of the
interest payable on this Note, or the date on which the interest becomes payable, including by suspending payment for a temporary period; and (ii) that the terms of this Note are subject to, and may be varied, if necessary, to give effect to,
the exercise of the Bail-in Power by the Relevant Resolution Authority. 

  
 A-3 

 “Amounts Due” means the principal amount of, premium, if any, together with any
accrued but unpaid interest, and Additional Amounts, if any, due on the Senior Non Preferred Notes. References to such amounts will include amounts that have become due and payable, but which have not been paid, prior to the exercise of the Bail-in
Power by the Relevant Resolution Authority. 
 “Bail-in Power” means any power existing from time to time under, and exercised in
compliance with, any laws, regulations, rules or requirements in effect in the Kingdom of Spain, relating to (i) the transposition of the BRRD, and in particular its article 59 (including but not limited to, Law 11/2015, RD 1012/2015 and any
other implementing regulations), (ii) the SRM Regulation and (iii) the instruments, rules or standards created thereunder, pursuant to which any obligation of a Regulated Entity (or an affiliate of such Regulated Entity) can be reduced,
cancelled, suspended, modified, or converted into shares, other securities, or other obligations of such Regulated Entity (or affiliate of such Regulated Entity). 

“Business Day” means any day, other than Saturday or Sunday, that is not a Legal Holiday nor a day on which banking institutions are
authorized or required by law, regulation or executive order to close in the City of New York or London nor a day when the Trans-European Automated Real-time Gross Settlement Express Transfer system (the “TARGET2 System”), or any successor
thereto, is closed for business. 
 “BRRD” means Directive 2014/59/EU of 15 May establishing the framework for the recovery
and resolution of credit institutions and investment firms or such other directive as may amend or come into effect in place thereof, as implemented into law by Law 11/2015 and RD 1012/2015, as amended or replaced from time to time and including any
other relevant implementing regulatory provisions. 
 “Law 11/2015” means Law 11/2015 of 18 June, on recovery and resolution
of credit institutions and investment firms (Ley 11/2015, de 18 de junio, de recuperación y resolución de entidades de crédito y empresas de servicios de inversión) as amended or replaced from time to time.

 “RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing Law 11/2015, as amended or superseded from time to
time. 
 “Regulated Entity” means any entity to which BRRD, as implemented in the Kingdom of Spain (including but not limited to,
Law 11/2015, RD 1012/2015 and any other implementing regulations), or any other Spanish law relating to the Bail-in Power, applies, which includes, certain credit institutions, investment firms, and certain of their parent or holding companies. 

“Relevant Resolution Authority” means the Spanish Fund for the Orderly Restructuring of Banks, the Bank of Spain, the European
Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the Bail-in Power or any other resolution power from time to time. 

  
 A-4 

 “SRM Regulation” means Regulation (EU) No. 806/2014 of the European
Parliament and of the Council of 15 July 2014, establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment firms in the framework of the Single Resolution Mechanism and the Single
Resolution Fund and amending Regulation (EU) No. 1093/2010, as amended or replaced from time to time. 
 The public deed of issuance
(escritura de emisión) related to the Senior Non Preferred Notes represented hereby was executed on March 22, 2022 before Mr. Miguel Ruiz Gallardón García de la Rasilla with the number 2,029 of his records. 

  
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 IN WITNESS WHEREOF, the Company has caused this Note to be duly executed. 

Dated: 
  

			
	BANCO SANTANDER, S.A., as Issuer
		
	By:	 	  

	Name:
	Title:

 [Global Note Signature Page] 

 

  
 A-6 

 CERTIFICATE OF AUTHENTICATION 

This is one of the Senior Non Preferred Debt Securities of the series designated herein referred to in the within-mentioned Senior Non
Preferred Debt Securities Indenture. 
 Dated: 
  

			
	THE BANK OF NEW YORK MELLON,
	London Branch, as Trustee
		
	By:	 	  

		 	Name:
		 	Title:

 [Global Note Signature Page] 

 

  
 A-7 

 [REVERSE OF SECURITY] 

This Note is one of a duly authorized issue of securities of the Company of the series designated Series 141 4.175% Senior Non Preferred
Fixed-to-Fixed Rate Notes due 2028 (herein called the “Senior Non Preferred Notes”) issued and to be issued in one or more series under a Senior Non Preferred Debt Securities Indenture, dated as of May 28, 2020, as heretofore
supplemented and amended (herein called the “Base Indenture”), between the Company, as issuer, and The Bank of New York Mellon, London Branch, as trustee (herein called the “Trustee”, which term includes any successor trustee
under the Base Indenture), as amended and supplemented by the Fourth Supplemental Indenture, dated as of March 24, 2022, among the Company, The Bank of New York Mellon, London Branch, as Trustee, Calculation Agent and Principal Paying Agent and
The Bank of New York Mellon SA/NV, Luxembourg Branch, as Senior Non Preferred Debt Securities Registrar (the “Fourth Supplemental Indenture”, and, the Base Indenture, as amended and supplemented by the Fourth Supplemental Indenture, the
“Senior Non Preferred Indenture”) to which Senior Non Preferred Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of
the Company and the Trustee and the Holders of the Senior Non Preferred Notes and of the terms upon which the Senior Non Preferred Notes are, and are to be, authenticated and delivered. Capitalized terms used herein are used as defined in the Senior
Non Preferred Indenture unless otherwise indicated. The terms of the Senior Non Preferred Notes include those stated in the Senior Non Preferred Indenture. The Senior Non Preferred Notes are subject to all such terms, and Holders are referred to the
Senior Non Preferred Indenture for a statement of all such terms. To the extent permitted by applicable law, in the event of any inconsistency between the terms of this Senior Non Preferred Note and the terms of the Senior Non Preferred Indenture,
the terms of the Senior Non Preferred Indenture will control. 
 This Note is one of the series designated on the face hereof, initially
limited in aggregate principal amount to $1,500,000,000; provided, that the Company may, from time to time, without the consent of the Holders of the Senior Non Preferred Notes, issue additional Senior Non Preferred Debt Securities under the Senior
Non Preferred Indenture, having the same ranking and same interest rate, maturity, redemption terms and other terms, except for the price to the public, original interest accrual date, issue date and first interest payment date, as the Senior Non
Preferred Notes; provided, however, that such additional Senior Non Preferred Notes will not have the same CUSIP, ISIN or other identifying number as the outstanding Senior Non Preferred Notes unless the additional Senior Non Preferred Notes
are fungible with the Senior Non Preferred Notes for U.S. federal income tax purposes. Any such additional Senior Non Preferred Notes, together with the Senior Non Preferred Notes, will constitute a single series of Senior Non Preferred Notes under
the Senior Non Preferred Indenture and shall be included in the definition of “Senior Non Preferred Debt Securities” in the Base Indenture where the context requires. 

The payment obligations of the Company under the Senior Non Preferred Notes on account of principal constitute direct, unconditional,
unsubordinated and unsecured senior non preferred obligations (créditos ordinarios no preferentes) of the Company and, in accordance with Additional Provision 14.2 of Law 11/2015, but subject to any other ranking that may apply as a
result of any mandatory provision of law (or otherwise), upon the insolvency of the Company, such payment obligations in respect of principal rank (i) pari passu among themselves 

 

  
 A-8 

 and with any Senior Non Preferred Liabilities (as defined below), (ii) junior to the Senior Higher
Priority Liabilities (as defined below) (and, accordingly, upon the insolvency of the Company, the claims in respect of principal under the Senior Non Preferred Notes will be met after payment in full of the Senior Higher Priority Liabilities) and
(iii) senior to any present and future subordinated obligations (créditos subordinados) of the Company in accordance with Article 281 of the Spanish Insolvency Law (as defined below). 

Claims of Holders of Senior Non Preferred Notes in respect of interest accrued but unpaid as of the commencement of any insolvency
procedure in respect of the Company shall constitute subordinated claims (créditos subordinados) against the Company ranking in accordance with the provisions of Article 281.1.3o of the Spanish Insolvency Law and no further
interest shall accrue from the date of the declaration of insolvency of the Company. 
 The obligations of the Company under the
Senior Non Preferred Notes are subject to the Bail-in Power. 
 “Law 11/2015” means Law 11/2015 of 18 June, on recovery
and resolution of credit institutions and investment firms (Ley 11/2015, de 18 de junio, de recuperación y resolución de entidades de crédito y empresas de servicios de inversión) as amended or replaced from
time to time. 
 “Senior Higher Priority Liabilities” means the unsubordinated and unsecured obligations (créditos
ordinarios) of the Company (including senior preferred debt securities ), other than the Senior Non Preferred Liabilities. 

“Senior Non Preferred Liabilities” means any unsubordinated and unsecured senior non preferred obligations (créditos
ordinarios no preferentes) of the Company under Additional Provision 14.2 of Law 11/2015 (including the Senior Non Preferred Notes) and any other obligations which, by law and/or by their terms, and to the extent permitted by Spanish law, rank
pari passu with the Senior Non Preferred Liabilities. 
 “Spanish Insolvency Law” means the restated text of the Spanish
Insolvency Law (Ley Concursal) approved by the Royal Decree-Legislative 1/2020, of 5 May, as amended from time to time. 
 The
provisions of Section 12.01 of the Senior Non Preferred Indenture, and Section 2.01(r) of the Fourth Supplemental Indenture shall apply only to rights or claims payable with respect to the Senior Non Preferred Notes and nothing herein
shall affect or prejudice the payment of the costs, charges, expenses, liabilities, indemnity or remuneration of the Trustee, the first lien rights of the Trustee under Section 6.08 of the Base Indenture, or the rights and remedies of the
Trustee in respect thereof. 
 The Company agrees with respect to the Senior Non Preferred Notes and each Holder of the Senior Non Preferred
Notes, by his or her acquisition of the Senior Non Preferred Notes will be deemed to have agreed to the ranking as described herein. Each such Holder will be deemed to have irrevocably waived his or her rights of priority which would otherwise be
accorded to him or her under the laws of Spain, to the extent necessary to effectuate the ranking provisions of the Senior Non Preferred Notes. In addition, each Holder of the Senior Non Preferred Notes by his or her acquisition of such Senior Non
Preferred Notes authorizes and directs the Trustee on his or her behalf to take such action as may be necessary or appropriate to effectuate the ranking of such Senior Non Preferred Notes as provided in the Senior Non Preferred Indenture, and as
summarized herein and appoints the Trustee as his or her attorney-in-fact for any and all such purposes. 

  
 A-9 

 Notwithstanding any other term of this Note or any other agreements, arrangements, or
understandings between the Company and any Holder of the Senior Non Preferred Notes, by its acquisition of this Note, each Holder (which includes each holder of a beneficial interest in this Note) acknowledges, accepts, consents to and agrees:
(i) to be bound by the effect of the exercise of the Bail-in Power by the Relevant Resolution Authority, which may include and result in any of the following, or some combination thereof: the reduction of all, or a portion, of the Amounts Due
on a permanent basis; the conversion of all, or a portion, of the Amounts Due into Common Equity Tier 1 instruments, other securities or other obligations of the Company or another person (and the issue to the Holder of such Common Equity Tier 1
instruments, securities or obligations), including by means of an amendment, modification or variation of the terms of the Senior Non Preferred Notes, in which case the Holder agrees to accept in lieu of its rights under this Note, any such Common
Equity Tier 1 instruments, other securities or other obligations of the Company or another person; the cancellation of this Note or Amounts Due; the amendment or alteration of the maturity of this Note or amendment of the interest payable on this
Note, or the date on which the interest becomes payable, including by suspending payment for a temporary period; and (ii) that the terms of this Note are subject to, and may be varied, if necessary, to give effect to, the exercise of the
Bail-in Power by the Relevant Resolution Authority. 
 “Amounts Due” means the principal amount of, premium, if any, together with
any accrued but unpaid interest, and Additional Amounts, if any, due on the Senior Non Preferred Notes. References to such amounts will include amounts that have become due and payable, but which have not been paid, prior to the exercise of the
Bail-in Power by the Relevant Resolution Authority. 
 “Bail-in Power” means any power existing from time to time under, and
exercised in compliance with, any laws, regulations, rules or requirements in effect in the Kingdom of Spain, relating to (i) the transposition of the BRRD, and in particular its article 59 (including but not limited to, Law 11/2015, RD
1012/2015 and any other implementing regulations), (ii) the SRM Regulation and (iii) the instruments, rules or standards created thereunder, pursuant to which any obligation of a Regulated Entity (or an affiliate of such Regulated Entity)
can be reduced, cancelled, suspended, modified, or converted into shares, other securities, or other obligations of such Regulated Entity (or affiliate of such Regulated Entity). 

“BRRD” means Directive 2014/59/EU of 15 May establishing the framework for the recovery and resolution of credit institutions
and investment firms or such other directive as may amend or come into effect in place thereof, as implemented into law by Law 11/2015 and RD 1012/2015, as amended or replaced from time to time and including any other relevant implementing
regulatory provisions. 
 “RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing Law 11/2015, as amended or
superseded from time to time. 
 “Regulated Entity” means any entity to which BRRD, as implemented in the Kingdom of Spain
(including but not limited to, Law 11/2015, RD 1012/2015 and any other implementing regulations), or any other Spanish law relating to the Bail-in Power, applies, which includes, certain credit institutions, investment firms, and certain of their
parent or holding companies. 

  
 A-10 

 “Relevant Resolution Authority” means the Spanish Fund for the Orderly
Restructuring of Banks, the Bank of Spain, the European Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the Bail-in Power or any other resolution power from time to time.

 “SRM Regulation” means Regulation (EU) No. 806/2014 of the European Parliament and of the Council of 15 July 2014,
establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment firms in the framework of the Single Resolution Mechanism and the Single Resolution Fund and amending Regulation (EU)
No. 1093/2010, as amended or replaced from time to time. 
 The exercise of the Bail-in Power by the Relevant Resolution Authority with
respect to the Senior Non Preferred Notes shall not constitute an event of default and the terms and conditions of the Senior Non Preferred Notes shall continue to apply in relation to the residual principal amount of, or outstanding amount payable
with respect to, the Senior Non Preferred Notes subject to any modification of the amount of distributions payable to reflect the reduction of the principal amount, and any further modification of the terms that the Relevant Resolution Authority may
decide in accordance with applicable laws and regulations relating to the resolution of credit institutions, investment firms and/or Company entities incorporated in the relevant member state. 

No repayment or payment of Amounts Due, if any, on the Senior Non Preferred Notes, will become due and payable or be paid after the exercise
of any Bail-in Power by the Relevant Resolution Authority if and to the extent such amounts have been reduced, converted, cancelled, amended or altered as a result of such exercise. 

By its acquisition of this Note, each Holder of this Note, (which, for the purposes of this clause, includes each Holder of a beneficial
interest in this Note), to the extent permitted by the Trust Indenture Act, will waive any and all claims, in law and/or in equity, against the Trustee for, agree not to initiate a suit against the Trustee in respect of, and agree that the Trustee
will not be liable for, any action that the Trustee takes, or abstains from taking, in either case in accordance with the exercise of the Bail-in Power by the Relevant Resolution Authority with respect to this Note. 

Additionally, by its acquisition of this Note, each Holder of this Note acknowledges and agrees that, upon the exercise of the Bail-in Power
by the Relevant Resolution Authority: 
 (i) the Trustee will not be required to take any further directions from the Holders of the Senior
Non Preferred Notes with respect to any portion of the Senior Non Preferred Notes that are written-down, converted to equity and/or cancelled under the Senior Non Preferred Indenture, which authorizes Holders of a majority in aggregate outstanding
principal amount of the outstanding Senior Non Preferred Notes to direct certain actions relating to the Senior Non Preferred Notes; and 

(ii) the Senior Non Preferred Indenture will not impose any duties upon the Trustee whatsoever with respect to the exercise of the Bail-in
Power by the Relevant Resolution Authority; 

  
 A-11 

 provided, however, that notwithstanding the exercise of the Bail-in Power by the
Relevant Resolution Authority, so long as the Senior Non Preferred Notes remain outstanding, there will at all times be a Trustee for the Senior Non Preferred Notes in accordance with the Senior Non Preferred Indenture, and the resignation and/or
removal of the Trustee and the appointment of a successor Trustee will continue to be governed by the Base Indenture, including to the extent no additional supplemental indenture or amendment is agreed upon in the event the Senior Non Preferred
Notes remain outstanding following the completion of the exercise of the Bail-in Power. 
 By its acquisition of this Note, each Holder of
this Note acknowledges and agrees that neither a cancellation or deemed cancellation of the principal or interest (in each case, in whole or in part), nor the exercise of the Bail-in Power by the Relevant Resolution Authority with respect to the
Senior Non Preferred Notes will give rise to a default for purposes of Section 315(b) (Notice of Default) and Section 315(c) (Duties of the Trustee in Case of Default) of the Trust Indenture Act. 

By purchasing this Note, each Holder (including each beneficial owner) of this Note shall be deemed to have authorized, directed and requested
DTC and any direct participant in DTC or other intermediary through which it holds this Note to take any and all necessary action, if required, to implement the exercise of the Bail-in Power with respect to the Senior Non Preferred Notes as it may
be imposed, without any further action or direction on the part of such Holder. 
 Each Holder of this Note also acknowledges and agrees
that the foregoing description of the Bail-in Power and its exercise is exhaustive on the matters described herein to the exclusion of any other agreements, arrangements or understandings relating to the application of any Bail-in Power to the
Senior Non Preferred Notes. 
 Each Holder of this Note that acquires such Senior Non Preferred Notes in the secondary market (including
each beneficial owner) shall be deemed to acknowledge, agree to be bound by and consent to the same provisions specified herein to the same extent as the Holders of the Senior Non Preferred Notes that acquire the Senior Non Preferred Notes upon
their initial issuance, including, without limitation, with respect to the acknowledgment and agreement to be bound by and consent to the terms of the Senior Non Preferred Notes, including in relation to the Bail-in-Power. 

Additional terms of the Senior Non Preferred Notes, including but not limited to events of default, remedies, payment of additional amounts in
respect of withholding tax, substitution and variation of the Senior Non Preferred Notes upon certain regulatory events, and amendment are set forth in the Senior Non Preferred Indenture. 

The Senior Non Preferred Indenture and the Senior Non Preferred Notes shall be governed by and construed in accordance with the laws of the
State of New York (without giving effect to the choice of law provisions), except for Section 12.01 of the Senior Non Preferred Indenture, Section 2.01(r) of the Fourth Supplemental Indenture and the status of the Senior Non Preferred
Notes, which shall be governed by and construed in accordance with the laws of The Kingdom of Spain, and except that the authorization and execution by the Company of the Senior Non Preferred Indenture and the Senior Non Preferred Notes shall be
governed by (in addition to the laws of the State of New York relevant to execution) the respective jurisdictions of organization of the Company and the Trustee, as the case may be. 

  
 A-12 

 The Senior Non Preferred Notes and this Note have been issued in the State of New York. 

 

  
 A-13

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