Document:

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                                                                  EXHIBIT 10.17

                               LICENSE AGREEMENT
                               -----------------

     This Agreement is made and entered into this Sixth day of January, 1996
(the "Effective Date") by and between Cold Spring Harbor Laboratory, a New York
corporation having its principal office at 1 Bungtown Road, Cold Spring Harbor,
New York 11724 (hereinafter referred to as "CSHL"), and Genomica Corporation, a
Delaware corporation having its principal office at Cold Spring Harbor, New York
(hereinafter referred to as "Licensee").

                                  WITNESSETH
                                  ----------

     WHEREAS, CSHL is the owner of certain Patent Rights, Copyrights and
Technical Information (as defined below) pertaining to GT (as defined in section
1.2) and also known as Genome Topographer.

     WHEREAS, GT was developed by Dr. Thomas Marr at CSHL under work supported,
in part, by grants from the Department of Energy DE-FG02-9lER61190 and the
National Institutes of Health IROI HG0020301A1; and

     WHEREAS, Licensee desires to obtain licenses from CSHL so that it may
commercialize the GT and make it commercially available;

     WHEREAS, CSHL desires to have the Patent Rights, Copyrights and Technical
Information utilized in the public interest and is willing to grant an exclusive
license thereunder; and

     NOW, THEREFORE, in consideration of the premises and the mutual covenants
contained herein, the parties hereto agree as follows:
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                            ARTICLE 1 - DEFINITIONS
                            -----------------------

     For the purpose of this Agreement, the following words and phrases shall
have the following meanings:

     1.1  "Affiliate" shall mean any corporation, company, partnership, joint
venture and/or firm which controls, is controlled by or is under common control
with Licensee. For purposes of this Section 1.1, "control" shall mean (a) in the
case of corporate entities, direct or indirect ownership of at least fifty
percent (50%) of the stock or shares entitled to vote for the election of
directors, and (b) in the case of non-corporate entities, direct or indirect
ownership of at least fifty percent (50%) of the equity interest with the power
to direct the management and policies of such on-corporate entities.

     1.2  "GT" shall mean a general purpose computing system useful for studying
complex genetic diseases.

     1.3  "Chang/Marr Algorithm" shall mean that portion of the GT which
incorporates either in software or hardware form an algorithm developed at CSHL
and described in "Approximate String Matching and Local Similarity" by William
I. Chang and Thomas G. Marr in Proc. Symp. Combinatorial Pattern Matching, 1994
                               ------------------------------------------
Springer-Verlag Lecture Notes in Computer Science 807:259-273 (June, 1994) and
described in U.S. Patent Application Serial No. 08/455,654 filed May 31, 1995.

     1.4  "Licensed Process" shall mean any process which is Covered in whole or
in part by a Valid Claim contained in the Patent Rights in the country in which
such process is used or which incorporates Licensed Copyrights or Technical
Information in its manufacture, use or sale;

     1.5  "Licensed Product" shall mean any product or part thereof, including
without limitation, software systems or apparatus which:

     (a)  is Covered in whole or in part by a Valid Claim contained in the
          Patent Rights in the country in which such product or part thereof is
          made, used or sold; or

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     (b)  is manufactured using a Licensed Process in the country in which such
          product or part thereof is manufactured; or

     (c)  which incorporates Licensed Copyrights or Technical Information in its
          manufacture, use or sale.

     1.6  "Valid Claim" shall mean an issued claim of an unexpired patent, or a
claim of a pending patent application, which shall not have been withdrawn,
cancelled or disclaimed, nor held invalid or unenforceable by a court of
competent jurisdiction in an unappealed or unappealable decision.

     1.7  "Covered" shall mean, with respect to a Valid Claim, that but for the
licenses granted herein, the manufacture, use or sale of the Licensed Product or
Licensed Process would be deemed to constitute an infringement of the Valid
Claim, whether the Valid Claim was in an issued patent or not.

     1.8  Subject to the provisions of Section 4.3 with respect to "portions" of
a Licensed Product, "Net Sales Price" with respect to Licensed Products shall
mean the gross billing price for a Licensed Product sold by Licensee or its
Affiliates or sub-licensees thereof less the sum of the following:

     (a)  rebates or discounts allowed;

     (b)  customs duties or charges;

     (c)  excises, sales taxes, tariff duties and/or other taxes imposed upon
          and with reference to such sales;

     (d)  outbound transportation charges, including freight, postage, insurance
          and additional special packaging charges, prepaid or allowed; and

     (e)  amounts allowed or credited for rejections, recalls or returns.

     No deductions shall be made for commissions paid to individuals, whether
they be with independent sales agencies or regularly employed by Licensee and on
its payroll, or for cost of collections. Licensed Products shall be considered
"sold" when billed out or invoiced. Transfer between Licensee and any of its
Affiliates for resale shall not be considered a sale, and in such

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case, the Net Sales Price shall be based on the gross billing price for the
Licensed Product as sold by the Affiliate, less those deductions set forth in
clauses (a) through (e) above.

     Subject to the provisions of Section 4.3 with respect to "portions" of a
Licensed Process, "Net Sales Price" with respect to a Licensed Process shall
mean the gross price charged by Licensee or its sublicensees to a customer for
the right to practice the Licensed Process.

     l.9   "Patent Rights" shall mean U.S. Patent Application Serial No.
08/455,654 filed May 31, 1995, and any United States and foreign patents issued
from said U.S. application and from divisionals and continuations of said
application; and any reissues or reexaminations of said application.

     1.10  "Technical Information" shall mean any information, including,
designs, formulas, process information, or algorithms pertaining to GT
technology or software (including object code and source code), or inventions
claimed in the Patent Rights or included in the Licensed Copyrights which
information is now, or during a period of five (5) years from the Effective Date
hereof, becomes owned or controlled by CSHL with a right to grant the license
granted herein and which has been or becomes developed by CSHL employees in Dr.
Marr's facilities at CSHL, during said five (5) year period. Notwithstanding the
preceding sentence, research data generated at CSHL shall be excluded from the
definition of Technical Information.

     1.11  "Copyrights" shall mean all elements of protection under national and
international copyright law including, without limitation, the right to make
enhancements, adaptations, and translations of copyrighted material.

     1.12  "Licensed Copyrights" shall mean all registered copyrights pertaining
to GT, which was developed by or for Dr. Thomas Marr at his facilities at CSHL
and which is now, or becomes, owned or controlled by CSHL within a period of
five (5) years from the Effective Date with the right to grant the license set
forth herein with respect to any of the Technical Information.

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                               ARTICLE 2 - GRANT
                               -----------------

     2.1  Subject to CSHL's rights in Section 2.3 and the government's rights in
Section 4.7, CSHL hereby grants to Licensee the worldwide, exclusive right and
license under the Patent Rights, Licensed Copyrights and Technical Information,
including the right to sublicense any or all of such rights, to make, have made,
use, have used, sell, have sold, offer to sell or import Licensed Products and
to practice and otherwise use the Licensed Processes until the later of the
expiration of the last to expire patent included in the Patent Rights or
copyright included in the Licensed Copyrights, unless this Agreement shall be
sooner terminated according to the terms hereof.

     2.2  As soon as reasonably possible following the date of execution of this
Agreement, but in no event later than three (3) months after such date, upon
request by Licensee, CSHL shall disclose to Licensee all Technical Information
presently in its possession or control.

     2.3  The parties recognize that CSHL is a basic research and educational
institute. CSHL therefore retains and reserves the right to publish any work
developed at CSHL. CSHL agrees to provide a draft disclosure of Technical
Information at least thirty (30) days in advance of submission for publication.
If Licensee believes that patentable subject matter is contained in the
submission, CSHL shall delay the submission up to an additional thirty (30) days
to permit the filing of a patent application pursuant to Article 6. CSHL further
reserves the right to practice under the Patent Rights, Licensed Copyrights and
Technical Information for its own noncommercial research purposes, provided that
the researcher is free to publish the results of the research. CSHL further
reserves the right to sublicense Dr. Marr to practice under the Patent Rights,
Licensed Copyrights and Technical Information under the same conditions for his
own noncommercial purposes. The Licensee grants to CSHL for research purposes a
royalty-free license to use Licensee developed products which incorporate the
Licensed Products (the "License Back"). The License Back includes software
updates. CSHL agrees to: (i) publish data developed through the use of GT in the
Licensee maintained GT data base on timeframes consistent with the publication
of the data in other public databases; (ii) work with the Licensee to

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actively promote the use of the developed product within CSHL; and (iii) pay
standard Licensee rates for services such as telephone and installation support.

     2.4     Licensee agrees to forward to CSHL, in advance, a copy of its
standard license agreements for Licensed Products, and to forward a copy of any
and all non-standard sublicense agreements at least five (5) working days prior
to the effective date thereof.

                           ARTICLE 3 - DUE DILIGENCE
                           -------------------------

     3.1     Licensee shall use its best efforts to develop and to bring to
market one or more Licensed Products and or Licensed Process for the field of
biological applications of the GT.

     3.2     As partial evidence of such efforts, the Licensee shall:

     3.2.1.  Fund sponsored research at CSHL in the amount of one hundred and
seventy thousand ($170,000.00) dollars per year, payable quarterly, for each of
the next two years. The first payment in the amount of forty-two thousand and
five hundred dollars ($42,500.00) shall be due on 1 April, 1996, and subsequent
payments in the same amount shall be due each 1 July, 1 October and 1 January
thereafter subject to the terms and conditions appended hereto as APPENDIX A.
This amount includes CSHL customary indirect costs.

     3.2.2.  On or before December 1, 1996 release at least one version of the
Licensed Product or Licensed Process.

     3.2.3.  On or before December 1, 1996, hire and retain sufficient
development personnel to effectively develop the Licensed Product and/or
Licensed Process and a support organization to sell, market and service the
Licensed Product and/or Licensed Process.

     3.2.4.  Spend at least two million ($2,000,000) dollars over a period of
three (3) years from the Effective Date towards development and
commercialization of the Licensed Product and Licensed Process. Sponsored
research funded at CSHL shall be credited against this amount.

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     3.2.5. Enter into an exclusive consulting contract with Dr. Marr in
accordance with the terms and conditions set forth in the Consultant Agreement
appended hereto as APPENDIX B.

     3.3    Upon written notification by CSHL of a field or fields other than
biological applications of the GT, Licensee shall present a business plan to
CSHL to develop and commercialize such field(s) and enter into good faith
negotiations with CSHL to exploit such field(s). As a minimum, Licensee shall
comply with the due diligence requirements of the aforementioned DOE and NIH
grants in order to maintain the exclusive licenses granted herein. In the event
the parties are unable to reach an agreement with respect to exploiting such
fields within one year from any particular notification, then at CSHL's option
the matter shall be submitted to mediation and/or arbitration as a dispute under
Article 13.

                        ARTICLE 4 - ROYALTIES AND FEES
                        ------------------------------

     4.1    Licensee shall pay to CSHL a license fee of 679,679 shares of
Licensee common stock upon execution of this Agreement, as outlined in the
Initial Capitalization Schedule of APPENDIX C attached hereto and subject only
to the terms of the Common Stock Acquisition Agreement attached hereto as
APPENDIX D. Licensee shall set aside a pool of additional shares for
distribution by CSHL and Licensee to future employees at Dr. Marr's laboratory
involved in the generation of improvements to the GT technology or software as
compensation for their potential contributions, in accordance with NIH
regulations.

     4.2    Licensee shall also pay: (i) the sum of $__________ as reimbursement
to CSHL for the patent and copyright expenses incurred up to the Effective Date
and relating to the Patent Rights and the GT, and (ii) the sum of thirty-three
thousand ($33,000) dollars to CSHL for renovation of space at CSHL for
accommodating Licensee personnel at CSHL.

     4.3    On all manufacture, use or sales of Licensed Products by Licensee or
its Affiliates or its sub-licensees or customers or sub-licensees of Licensee or
its Affiliates and all use of a Licensed Process by a customer of Licensee or
its Affiliates during the term of the license granted

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in Section 2.1 above, for intended use in the field of biological applications,
including, without limitation, gene based drug research and development,
Licensee shall pay to CSHL earned royalties at the rate of 2% of the Net Sales
Price of that portion of the Net Sales Price of the Licensed Product or Licensed
Process which is attributable to the Chang/Marr Algorithm, taking into account
the added value of the Chang/Marr Algorithm to the Licensed Product or Licensed
Process, prevailing industry standards with respect to software licenses, profit
potential, market potential and additional research and development required. In
the event the parties are unable to agree on "that portion" prior to first sale
of a Licensed Product or Licensed Process, the matter shall be resolved as a
dispute under Article 13. For intended use outside of the preceding field of
biological applications, the earned royalty rate shall be 10% of the Net Sales
Price of "that portion" (as computed above) of the Licensed Product or Licensed
Process which relates to, or incorporates, the Chang/Marr Algorithm.

     4.4  In no event shall more than one royalty pursuant to the terms of
Section 4.3 be due CSHL in respect of any Licensed Product or Licensed Process
despite the fact that such Licensed Product, or its method of manufacture or
use, is or shall be Covered by more than one Valid Claim contained in the Patent
Rights.

     4.5  Notwithstanding the foregoing Sections 4.3 and 4.4, in the event
Licensee sub-licenses any of the rights granted herein, CSHL shall be paid 10%
of any compensation or consideration attributable to the Chang/Marr Algorithm
(hereinafter "Income") and paid to Licensee for such rights, in addition to the
royalty specified in Article 4.3 as applied to the Net Selling Price of Licensed
Products or Licensed Process sold by the sublicensee.

     4.6  Royalty and other payments hereunder shall be paid in United States
dollars to CSHL at its principal office, or at such other place as CSHL may
reasonably designate consistent with the laws and regulations controlling in any
foreign country. CSHL shall reimburse Licensee for any payments lawfully made by
Licensee to any foreign country for fees otherwise due such country directly
from CSHL. If any currency conversion shall be required in connection with the
payment of royalties and other payments hereunder, such conversion shall be made
by using the

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exchange rate prevailing at the Chase Manhattan Bank, N.A. (hereinafter "Chase
Manhattan Bank") in New York, New York, on the last business day of the royalty
reporting period to which such royalty or other payments relate. If by law,
regulation, or fiscal policy of a particular country, conversion into or
transfer to United States dollars is restricted or forbidden, Licensee shall
give CSHL prompt notice in writing and shall pay the royalty and other amounts
due through such lawful means or methods as CSHL may reasonably designate.
Failing the designation by CSHL of such lawful means or methods within fifteen
(15) days after such notice is given to CSHL, Licensee shall deposit the royalty
payment due in local currency to the credit of CSHL in a recognized banking
institution designated by CSHL or, if none is designated by CSHL within the
period of fifteen (15) days as described above, in a recognized banking
institution selected by Licensee and identified in a notice in writing given to
CSHL by Licensee. When in any country the law or regulations prohibit both the
transmittal and deposit of royalties on sales in such country, royalty payments
shall be suspended for as long as such prohibition is in effect, and as soon as
such prohibition ceases to be in effect, all royalties which License would have
been under obligation to transmit or deposit, but for the prohibition, shall be
deposited or transmitted promptly to the extent allowable.

     4.7  Licensee understands that the Patent Rights and Licensed Copyrights
were developed with support provided in part by funds of United States federal
agencies and, therefore, Licensee agrees that the rights granted Licensee
hereunder are subject to applicable limitations and United States governmental
rights established by United States law, including 35 U.S.C. Sections 200-212
and the regulations promulgated thereunder in 37 C.F.R. Part 401.

     4.8  Licensee shall not owe CSHL the royalties set forth in Section 4.3
above on sales of Licensed Products to the United States government when the
government reduces the Net Sales Price paid by it for such Licensed Products by
the amount of the royalty due CSHL hereunder on the basis of its royalty-free
license for government use of the Patent Rights or Licensed Copyrights for which
the royalty, in the absence of such license, would be due hereunder.

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                        ARTICLE 5 - REPORTS AND RECORD
                        ------------------------------

     5.1  Licensee shall keep full, true and accurate books of account and other
records containing all particulars that may be necessary for the purpose of
showing the amounts payable to CSHL hereunder. Said books of account shall be
kept at Licensee's principal place of business. Said books and other records
shall be available during normal business hours, upon two (2) business days'
prior written notice by CSHL, for two (2) years following the end of the
calendar year to which they pertain, to the inspection of CSHL or its agents
(not to exceed once during each calendar year) for the sole purpose of verifying
Licensee's royalty statements or compliance in other respects with this
Agreement. Such inspection shall be at the sole cost and expenses of CSHL;
provided, however, should such inspection lead to the discovery of a greater
than ten percent (10%) discrepancy in reporting of royalties or other payments
due hereunder, Licensee shall pay the full cost and expense of such inspection.

     5.2  Commencing with the calendar quarter in which the first commercial
sales of any Licensed Product occurs, or the calendar quarter in which
sublicense income is first received by Licensee, whichever occurs sooner,
Licensee shall submit to CSHL, within sixty (60) days after March 31, June 30,
September 30 and December 31 of each year, true and accurate reports, giving the
following particulars of the business conducted by Licensee, its Affiliates and
its sublicensees during the preceding three-month, period under this Agreement,
as such particulars shall be pertinent to an accounting of royalties or other
payments due hereunder:

     (a)  number of Licensed Products sold by Licensee and its Affiliates in
          each country;

     (b)  total billings for Licensed Products sold by Licensee, its
          sublicensees and its Affiliates in each country;

     (c)  amount of Income received from sublicensees;

     (d)  applicable deductions from Net Sales Price as provided in Section 1.8;
          and

     (e)  total royalties and/or portion of sublicense Income due to CSHL
          hereunder.

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     5.3  With each such report submitted, Licensee shall pay to CSHL the
royalties and/or portion of sublicense Income due and payable under this
Agreement. If no royalties and/or portion of sublicense Income shall be due,
Licensee shall so report.

     5.4  The royalty and other payments set forth in this Agreement and any
amounts due under Article 6 shall, if overdue, bear interest until paid at a per
annum rate two percent (2%) above the prime rate in effect at Chase Manhattan
Bank on the due date. The payment of such interest shall not foreclose CSHL from
exercising any other rights it may have as a consequence of the lateness of any
payment.

                        ARTICLE 6 - PATENT PROSECUTION
                        ------------------------------

     6.1  Except as provided in this Article 6, CSHL shall be responsible, at
its sole discretion, for the preparation, filing, prosecution and maintenance of
all patent applications and patents included in the Patent Rights in the United
States and to the extent warranted in any foreign countries. CSHL shall consult
regularly with Licensee and shall provide copies to Licensee of all filings,
office actions and proposed responses and shall endeavor to provide Licensee
with a meaningful opportunity to participate in decisions regarding the filing,
prosecution and maintenance of those patent applications. Licensee shall
reimburse CSHL for all reasonable costs incurred by CSHL subsequent to the
Effective Date of this Agreement for the preparation, filing, prosecution and
maintenance of all Patent Rights.

     6.2  CSHL shall not abandon the prosecution of any patent applications
included in the Patent Rights nor shall it fail to make any payment or fail to
take any other action necessary to maintain a patent included in the Patent
Rights unless it has notified Licensee at least thirty (30) days prior thereto,
whereupon Licensee shall have the option to prosecute and maintain such patent
or patent application at its own expense.

     6.3  For the first five (5) years after the Effective Date, CSHL shall
provide Licensee with copies of any invention disclosures by CSHL employees who
are then employed in Dr.

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Marr's facilities at CSHL, to the extent submitted prior to publication to the
Administrative Director or Assistant Administrative Director of CSHL and solely
relating to the Licensed Product or Licensed Process. Licensee shall have a
period of not more than sixty (60) days from the date of receipt of said copies
in which to inform CSHL of its decision to have such a disclosure filed as a
U.S. and/or foreign patent application; in which event, CSHL shall, with due
diligence, file such a patent application at Licensee's expense, whereupon it
shall become a Patent Right hereunder subject to all provisions in this
Agreement referring to "Patent Right(s)."

                           ARTICLE 7 - INFRINGEMENT
                           ------------------------

     7.1  Each Party shall inform the other Party promptly in writing of any
alleged infringement of the Patent Rights or Licensed Copyrights by a third
party, of which such Party shall have knowledge, and of any available evidence
thereof.

     7.2  During the term of this Agreement, CSHL shall have the right, but
shall not be obligated, to prosecute at its own expense any infringements of the
Patent Rights and, in furtherance of such rights, Licensee hereby agrees that
CSHL may join Licensee as a party plaintiff in any such suit, without expense to
Licensee. CSHL shall hold harmless and indemnify Licensee from and against any
order for costs arising without fault of Licensee that may be made against CSHL
or Licensee in such proceedings. The total cost of any infringement action
commenced or defended solely by CSHL shall be borne by CSHL. Any recovery or
damages for past infringement derived from such action shall first be used to
reimburse CSHL for all legal expenses connected with such action. Any recovery
or damages still remaining shall be applied toward (i) reimbursement of CSHL for
the amount of royalties not received by CSHL as a result of such infringement,
and (ii) compensation of Licensee for its lost profits or a reasonable royalty
on the sales of the infringer, whichever measure of damages the court shall have
applied; provided, however, that if such remaining amount of recovery or damages
is insufficient to compensate CSHL fully for such royalties and to compensate
Licensee fully for such lost profits or reasonable royalty, then such amount of
recovery or damages still remaining shall be

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apportioned pro rata between CSHL and Licensee in proportion to (a) the amount
of royalties not received by CSHL as a result of such infringement, as compared
with (b) Licensee's lost profits or a reasonable royalty on the sales of the
infringer, whichever measure of damages the court shall have applied. Any
recovery or damages still remaining after the above-mentioned applications shall
be divided as follows: 50% to CSHL and the remaining 50% to Licensee.

     7.3  If within six (6) months after having been notified of any alleged
infringement CSHL shall have been unsuccessful in causing the alleged infringer
to desist or shall not have brought and shall not be diligently prosecuting an
infringement action, or if CSHL shall notify Licensee at any time prior thereto
of its intention not to bring suit against any alleged infringer, then, in those
events only, Licensee shall have the right, but shall not be obligated, to
prosecute at its own expense any such infringement of the Patent Rights and, in
furtherance of such rights, CSHL hereby agrees that Licensee may join CSHL as a
party plaintiff in any such suit, without expense to CSHL. No settlement,
consent judgment or other voluntary final disposition of the suit may be entered
into without the consent of CSHL, which consent shall not unreasonably be
withheld. Licensee shall hold harmless and indemnify CSHL from and against any
order for costs arising without fault of CSHL that may be made against Licensee
or CSHL in such proceedings. The total cost of any infringement action commenced
or defended by Licensee shall be borne by Licensee. Any recovery or damages for
past infringement derived from such action shall first be used to reimburse
Licensee for all legal expenses connected with such action. Any recovery or
damages still remaining shall be applied toward (i) reimbursement of CSHL for
the amount of royalties not received by CSHL as a result of such infringement,
and (ii) compensation of Licensee for its lost profits or a reasonable royalty
on the sales of the infringer, whichever measure of damages the court shall have
applied; provided, however, that if such remaining amount of recovery or damages
is insufficient to compensate CSHL fully for such royalties and to compensate
Licensee fully for such lost profits or reasonable royalty, then such amount of
recovery or damages still remaining shall be apportioned pro rata between CSHL
and Licensee in proportion to (a) the amount of royalties not received by CSHL
as a result of such infringement,

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as compared with (b) Licensee's lost profits or a reasonable royalty on the
sales of the infringer, whichever measure of damages the court shall have
applied. Any recovery or damages still remaining after the above-mentioned
applications shall be divided as follows: 50% to CSHL and the remaining 50% to
Licensee.

                  ARTICLE 8 - PRODUCT LIABILITY AND WARRANTY
                  ------------------------------------------

     8.1  Except to the extent resulting from the gross negligence or
intentional misconduct or material breach of this Agreement by CSHL, which
breach remains uncured beyond a ninety (90) day period from the date of receipt
of notice of breach, Licensee shall at all times during the term of this
Agreement and thereafter, indemnify, defend and hold CSHL, its trustees,
officers, employees and affiliates, harmless from and against all actions,
suits, claims, demands, judgments, liabilities and expenses, including legal
expenses and reasonable attorneys' fees, arising out of the development,
manufacture, sale, distribution or use of Licensed Products or Licensed
Processes or the presence of Licensees employees, sublicensees or agents in or
on the premises of CSHL, including, without limitation, any claim arising out of
the death of or injury to any person or persons or out of any damage to
property, or arising out of the exercise of rights granted hereunder by
Licensee, its Affiliates or its sublicensees. CSHL shall promptly notify
Licensee in writing of any such action, suit, claim or demand. Licensee shall
manage and control, at its sole expense, the defense of any such action, suit,
claim or demand. CSHL shall not agree to any settlement without Licensee's
consent.

     8.2  Licensee shall promptly obtain and carry in full force and effect
product liability insurance against any claims, judgments, liabilities and
expenses for which it is obligated to indemnify CSHL under Section 8.1 above, in
such amounts and with such deductibles and other limits as are customary in the
software industry to protect against this eventuality.

     A copy of a policy for such insurance shall be provided to CSHL within
thirty (30) days of the Effective Date.

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<PAGE>

     8.3  CSHL represents and warrants that it is the sole owner of the Patent
Rights, and Licensed Copyrights, subject to any rights of the United States
government, and that it has the authority to grant the licenses granted
hereunder, and that it has not knowingly taken any actions that would adversely
affect the validity of the Patent Rights. CSHL warrants that as of the date of
execution of this Agreement, it has not received actual notice of any patents or
patent applications or copyrights owned by third parties which would prevent
Licensee from making, using or selling Licensed Products or practicing or
otherwise using the Licensed Processes. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH
IN THIS AGREEMENT, CSHL MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF
ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF
MERCHANTABILITY OF THE LICENSED PRODUCT OR LICENSED PROCESS, FITNESS FOR A
PARTICULAR PURPOSE OF THE LICENSED PRODUCT OR LICENSED PROCESS, OR VALIDITY OR
ENFORCEMENT OF PATENT RIGHTS OR LICENSED COPYRIGHTS. NOTHING IN THIS AGREEMENT
SHALL BE CONSTRUED AS A REPRESENTATION MADE OR WARRANTY GIVEN BY CSHL THAT THE
PRACTICE BY LICENSEE OF THE LICENSES GRANTED HEREUNDER SHALL NOT INFRINGE THE
INTELLECTUAL PROPERTY RIGHTS OF ANY THIRD PARTY.

                           ARTICLE 9 - COLLABORATION
                           -------------------------

     9.1  CSHL and Licensee desire to establish a broad collaboration with
respect to further developments emanating from Dr. Marr's facilities at CSHL.

     9.2  In furtherance of the spirit of collaboration of the Parties, CSHL
agrees to provide up to eight (8) employees of Licensee with access, during a
period of two (2) years after the date of execution of this Agreement and during
normal business hours, to CSHL's laboratories for the sole purpose of conducting
computer software development and research on GT under the direction of Dr.
Marr.

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     These employees shall be in addition to any employees funded by Licensee
sponsored research at CSHL. Licensee shall be responsible for any salaries,
expenses and additional capital equipment required by these employees and for
rent for the facilities and services used by such Licensee's employees, in
accordance with the Lease Agreement appended hereto as APPENDIX E.

                         ARTICLE 10 - EXPORT CONTROLS
                         ----------------------------

     It is understood that CSHL and Licensee are subject to United States laws
and regulations controlling the export of technical data, computer software,
laboratory prototypes and other commodities (including the Arms Export Control
Act, as amended, and the Export Administration Act of 1979), and that its
obligations hereunder are contingent on compliance with applicable united States
export laws and regulations. The transfer of certain technical data and
commodities may require a license from the applicable agency of the United
States Government and/or written assurances by Licensee that Licensee shall not
export data or commodities to certain foreign countries without prior approval
of such agency. CSHL neither represents that a license shall not be required nor
that, if required, it shall be issued.

               ARTICLE 11 - CONFIDENTIALITY AND NON-USE OF NAMES
               -------------------------------------------------

     11.1  Licensee shall maintain the Proprietary Technical Information in
confidence, and shall not disclose, divulge or otherwise communicate such
Information to others, or use it for any purpose, except pursuant to, and in
order to carry out, the terms and objectives of this Agreement, and hereby
agrees to exercise every reasonable precaution to prevent and restrain the
unauthorized disclosure (except to the extent necessary incident to the use or
sale of Licensed Products or Licensed Processes) of such Information by any of
its directors, officers, employees, consultants, subcontractors, sublicensees or
agents.

     11.2  The provisions of Section 11.1 shall not apply to any Information
disclosed hereunder which:

                                      -16-
<PAGE>

     (a)  was known or used by Licensee prior to its date of disclosure to
          Licensee, as evidenced by the prior written records of Licensee; or

     (b)  either before or after the date of the disclosure to Licensee is
          lawfully disclosed to Licensee by sources other than CSHL who are
          rightfully in possession of the Information; or

     (c)  either before or after the date of the disclosure to Licensee is or
          was published or generally known to the public through no fault or
          omission on the part of Licensee provided, however, that the sale of
          Licensed Products or use of Licensed Processes in the ordinary course
          shall not constitute fault or omission;

     (d)  is independently developed by or for the Licensee without reference to
          or reliance upon the Information; or

     (e)  is required to be disclosed by Licensee to comply with applicable
          laws, to defend or prosecute litigation or to comply with governmental
          regulations, or to be used in patent applications to be filed under
          this Agreement, provided that the Licensee provides prior written
                          -------- ----
          notice of such disclosure to CSHL and takes reasonable and lawful
          actions to avoid and/or minimize the degree of such disclosure.

     11.3 Neither Party shall use the names or trademarks of the other Party,
nor any adaptation thereof, nor the names of any of its employees, in any
advertising, promotional or sales literature without prior written consent
obtained from such other Party, or said employee, in each case, except that
Licensee may state that it is licensed by CSHL under one or more of the patents
and/or applications included in the Patent Rights and Licensed Copyrights.

     11.4 A Party shall not disclose, divulge or otherwise communicate the
existence or terms of this Agreement to others except to the extent such
existence or terms (i) become published or generally known to the public through
no fault or omission of such Party; (ii) are required to be disclosed to comply
with applicable laws, to defend or prosecute litigation or to comply with
governmental regulations, or (iii) are required to be disclosed to potential
investors in Licensee, existing shareholders of Licensee, or otherwise as
necessary to conduct the business of Licensee, provided that in the case of
                                               -------- ----
(ii), or (iii) such Party provides prior written notice of such disclosure to
the other Party and takes reasonable and lawful actions to avoid and/or minimize
the degree of such disclosure; including, where possible, disclosing the
information under an agreement of confidentiality for the benefit of the other
Party.

                                      -17-
<PAGE>

                            ARTICLE 12 - ASSIGNMENT
                            -----------------------

     This Agreement is not assignable by Licensee or CSHL by operation of law or
otherwise, except that it is assignable by Licensee in connection with a merger
or consolidation of Licensee with or into another business entity or sale of all
or substantially all of Licensee's business or assets or stock to a business
entity or business person that assumes Licensee's obligations hereunder in
writing.

                        ARTICLE 13 - DISPUTE RESOLUTION
                        -------------------------------

     13.1  Except for the right of either Party to apply to a court of competent
jurisdiction for a temporary restraining order, a preliminary injunction, or
other equitable relief to preserve the status quo or prevent irreparable harm
and except for any dispute involving Section 14.2, any and all claims, disputes
or controversies arising under, out of, or in connection with this Agreement,
including, without limitation, any dispute relating to "compensation" or
"consideration" attributable to the Chang/Marr Algorithm in Section 4.5 or
patent validity or infringement, which the Parties shall be unable to resolve
within sixty (60) days, shall be mediated in good faith. The Party raising such
dispute shall promptly advise the other Party of such claim, dispute or
controversy in a writing which describes in reasonable detail the nature of such
dispute. By not later than five (5) business days after the recipient has
received such notice of dispute, each Party shall have selected for itself a
representative who shall have the authority to bind such Party, and shall
additionally have advised the other Party in writing of the name and title of
such representative. Such representatives shall schedule a date for a mediation
hearing with a mediator jointly selected by such representatives in New York,
New York on a date not later than ten (10) business days after the date of such
notice of dispute, or if no dates are available in such period, then the first
available date thereafter. The parties shall thereupon enter into good faith
mediation and shall share the costs equally. If the representatives of the
parties have not been able to jointly select a mediator or to resolve the
dispute within fifteen (15) business days after the earlier of attempting to
jointly select a mediator or the occurrence of such mediation hearing, the
parties

                                      -18-
<PAGE>

shall submit the matter to arbitration, in good faith in New York, New York, in
accordance with the rules and practices of the American Arbitration Association.
The decision of the arbitrator(s) shall be binding on the parties and
enforceable in any court of competent jurisdiction.

     13.2  Notwithstanding the foregoing, nothing in this Article 13 shall be
construed to waive any rights or timely performance of any obligations existing
under this Agreement.

                           ARTICLE 14 - TERMINATION
                           ------------------------

     14.1  If Licensee shall cease to carry on its business or at any time
commit any act of bankruptcy, or become bankrupt, or have a receivership order
made against it, or make or execute any bill of sale, deed of trust, or
assignment for the benefit of creditors, this Agreement shall terminate upon
notice by CSHL.

     14.2  Should Licensee fail to make any payment whatsoever due and payable
to CSHL hereunder, CSHL shall have the right to terminate this Agreement
effective on thirty (30) days' notice, unless Licensee shall make all such
payments to CSHL within said thirty (30) day period. Upon the expiration of the
thirty (30) days period, if Licensee shall not have made all such payments to
CSHL, CSHL may, immediately upon notice to Licensee, terminate this Agreement
and the rights, privileges and license granted hereunder.

     14.3  Upon any material breach or default of this Agreement by Licensee,
other than those occurrences set out in Section 14.1 and 14.2 above, which shall
always take precedence in that order over any material breach or default
referred to in this Section 14.3, CSHL shall have the right to terminate this
Agreement and the rights, privileges and license granted hereunder effective on
ninety (90) days' notice to Licensee. Such termination shall become
automatically effective unless Licensee shall have cured any such material
breach or default prior to the expiration of the ninety (90) day period. Upon
any termination under Sections 14.1, 14.2, or 14.3, Licensee shall promptly
return all Proprietary Technical Information theretofore supplied to it by CSHL
and any copies made by or for it, its Affiliates or sublicensees.

                                      -19-
<PAGE>

     14.4  Licensee shall have the right to terminate this Agreement at any time
on six (6) months' notice to CSHL, and upon payment of all amounts due CSHL
through the effective date of termination.

     14.5  Upon termination of this Agreement for any reason, nothing herein
shall be construed to release either party from any obligation that matured
prior to the effective date of such termination. Licensee and any sublicensee
thereof may, however, after the effective date of such termination, sell all
Licensed Products, and complete Licensed Products in the process of manufacture
at the time of such termination and sell the same, provided that Licensee shall
pay to CSHL the royalties thereon as required by Section 4.3 of this Agreement
and shall submit the reports required by Article 5 hereof on the sale of
Licensed Products.

     14.6  Upon termination of this Agreement for any reason, CSHL shall
recognize the sublicenses granted by the Licensee under the rights licensed
hereunder, provided that CSHL (i) thereafter shall have the right to receive any
payments or other consideration payable to Licensee thereunder, (ii) thereafter
shall have the right to terminate the sublicense upon thirty (30) days' notice
of a material breach by the sublicensee which is not cured prior to expiration
of such thirty (30) day period, and (iii) shall not assume, and shall not be
responsible to any sublicensees for, any representations, warranties or
obligations of Licensee to any sublicensees other than as set forth herein.

     14.7  The provisions of Article II shall survive any expiration or
termination of this Agreement.

                        ARTICLE 15 - PAYMENTS, NOTICES
                        ------------------------------
                           AND OTHER COMMUNICATIONS
                           ------------------------

     Any payment, notice or other communication pursuant to this Agreement shall
be sufficiently made or given by the sending Party (i) upon personal delivery to
the receiving Party, or (ii) two (2) days after deposit with the United States
Postal Service, registered or certified first class mail, postage prepaid,
return receipt requested, addressed to the receiving Party at its

                                      -20-
<PAGE>

address set forth below, or at such other address of which the receiving Party
shall have notified the sending Party in a notice given in accordance with this
Article 15.

     In the case of CSHL:

                 Mr. John Maroney
             ------------------------------------------

                 Assistant Administrative Director
             ------------------------------------------

                 Box 100. 1 Bungtown Road
             ------------------------------------------

                 Cold Spring Harbor, New York 11724
             ------------------------------------------

     In the case of Licensee:

                 Mr. James L. Rathmann
             ------------------------------------------

                 President, Genomica Corporation
             ------------------------------------------

                 600 Dorset Road
             ------------------------------------------

                 Devon, Pennsylvania 19333
             ------------------------------------------

                     ARTICLE 16 - MISCELLANEOUS PROVISIONS
                     -------------------------------------

     16.1    This Agreement shall be construed, governed, interpreted and
applied in accordance with the laws of the State of New York, U.S.A., without
giving effect to its conflict of laws provisions, except that questions
affecting the constructions and effect of any patent shall be determined by the
law of the country in which the patent was granted.

     16.2    The parties hereto acknowledge that this Agreement (including the
Appendices hereto) sets forth the entire Agreement and understanding of the
parties hereto as to the subject matter hereof, and shall not be subject to any
change or modification except by the execution of a written instrument
subscribed to by the parties hereto.

                                      -21-
<PAGE>

     16.3  The provisions of this Agreement are severable, and in the event
that any provisions of this Agreement shall be determined to be invalid or
unenforceable under any controlling body of the law, such invalidity or
unenforceability shall not in any way affect the validity of enforceability of
the remaining provisions hereof.

     16.4  Licensee agrees to mark the Licensed Products sold by it with any
notice of patent rights reasonably necessary or desirable under applicable law
to enable the Patent Rights to be enforced to the maximum degree in the country
where such Licensed Products are sold.

           In the event any Technical Information bears a Copyright Notice,
Licensee shall not remove such notice and it shall be retained or reproduced in
its exact form on all authorized copies and versions of Licensed Product(s) or
the Licensed Process, both in machine and human readable language.

     16.5  The failure of either party to assert a right hereunder or to insist
upon compliance with any term or condition of this Agreement shall not
constitute a waiver of that right or excuse a similar subsequent failure to
perform any such term or condition by the other party.

                                      -22-
<PAGE>

     IN WITNESS WHEREOF, the parties have duly executed this Agreement the day
and year set forth below.

                              COLD SPRING HARBOR LABORATORY

                              By: /s/ John Maroney
                                 --------------------------------------

                              Name:   John Maroney
                                   ------------------------------------

                              Title:  Assistant Administrative Director
                                    -----------------------------------

                              Date:   3/25/96
                                   ------------------------------------

                              GENOMICA CORPORATION

                              By: /s/ James L. Rathmann
                                 --------------------------------------

                              Name:   James L. Rathmann
                                   ------------------------------------

                              Title:  President
                                    -----------------------------------

                              Date:   3
                                   ------------------------------------

                                      -23-<PAGE>
                                                                   EXHIBIT 10.18

          GEMSTONE SYSTEMS, INC. DOMESTIC SOFTWARE LICENSE AGREEMENT

This Agreement is made by and between GemsStone Systems, Inc. ("GEMSTONE"), an
Oregon corporation, and the Licensee, each being identified and having a place
of business as given on the face of this Agreement.

1.   DEFINITIONS
----------------

As used herein, the terms set forth below shall have the following respective
meanings:

1.1  "GEMSTONE" shall mean GemStone Systems, Inc., and shall not mean any
subsidiary, affiliate, or other person or entity associated with GemStone
Systems, Inc.

1.2  "Licensee" shall mean the entity identified on the face page of this
Agreement, and shall not mean any subsidiary, affiliate, or other person or
entity associated the Licensee, including, without limitation, any governmental
authority.

1.3  "Software Products" shall mean the products identified in the Product
Description on the face page of this Agreement in the form delivered, for which
the terms of payment set out in Section 8.0 PAYMENT below have been met, and all
updates of the same provided to Licensee under the terms of this Agreement.

1.4  "Documentation" shall mean manuals identified in the Product Description on
the face page of this Agreement.

1.5  "Server Computer System" shall mean a computer system that executes control
processes within a GemStone environment and contains one or more extents of a
single Logical GemStone Database.  Server Computer Systems may be at the same
site or at geographically distributed sites from other Server Computer Systems
or Client Computer Systems.

1.6  "Client Computer System" shall mean a computer system that can execute
Software Products that access a single Logical GemStone Database.  Client
Computer Systems may be at the same site or at geographically distributed sites
from Server Computer Systems or other Client Computer Systems.

1.7  "Logical GemStone Database" shall mean a domain of information controlled
by a common schema and common control processes within a GemStone environment.
A Logical GemStone Data can span multiple Server Computer Systems.

1.8  "Named Developer" shall mean an individual who is authorized by Licensee to
develop and/or run applications using Software Products that access a single
Logical GemStone Database.

1.9  "Named User" shall mean an individual who is authorized by Licensee to run
applications using Software Products that access a single Logical GemStone
Database; a Named Developer, or an unattended hardware device that could supply
information to or obtain information from the Logical GemStone Database.

1.10 "Concurrent User" shall mean an individual who is connected to a
Licensee's single Logical GemStone Database; an individual connected to the
Logical GemStone Database through a multiplexed front end, such as a transaction
processing monitor, or an unattended hardware device that is connected to the
Logical GemStone Database.

2.   LICENSE GRANT
------------------

2.1  GEMSTONE hereby grants to Licensee, and Licensee hereby accepts from
GEMSTONE, a non-exclusive license, without right to sublicense, to use the
Software Products and Documentation; provided, however, that such use of the
Software Products shall be limited to use by Licensee accessing a single Logical
GemStone Database on Server Computer Systems or on Client Computer Systems
connected to Server Computer Systems.  Access to or use of a form or release of
Software Products other than as delivered is not granted by this license.
GEMSTONE reserves all rights not expressly granted by this Agreement.

2.2  Licensee's use of Software Products is limited to use by the number of
Named Developers, Named Users, or Concurrent Users so indicated on the Product
Description page of this Agreement plus any subsequent Named Developers, Named
Users, or Concurrent Users indicated in any authorized amendment to this
Agreement.  Users indicated in any authorized amendment to this Agreement.
Licensee shall have in place with its Named Developers, Named Users, Concurrent
Users, employees, agents and others appropriate agreements to satisfy Licensee's
obligations under this Agreement, including, but not limited to obligations
undertaken in Section 7.

2.3  Software Products may be removed from one Server Computer System and
transferred to another Server Computer System or from one Client Computer System
and transferred to another Client Computer System after notification to
GEMSTONE.  An associated transfer fee will be assessed.  Use of Software
Products may be transferred from one Named Developer to another Named Developer,
or from one Named User to another Named User, or from one Concurrent User to
another Concurrent User without charge.

3.   OWNERSHIP
--------------

3.1  Title to and ownership of Software Products, including all copies thereof,
and all rights therein including trade secrets, patents and copyrights, shall
remain with GEMSTONE.  No title or ownership of Software Products or any part
thereof, is transferred to Licensee.

4.   PROPRIETARY NOTICES
------------------------

4.1  Licensee shall not remove or alter GEMSTONE's ownership, trademark,
copyright, or other proprietary notice on Software Products or Documentation.

4.2  Where applicable, the Software Products and Documentation shall be marked
with appropriate Restricted Rights legends under the Federal Acquisition
Regulations (FAR) or other similar regulations.  The Software Products are
provided only with restricted rights as set out in this Agreement.

5.   USE RESTRICTIONS
---------------------

5.1  Licensee shall not modify, adapt, translate, reverse engineer, decompile,
or disassemble Software Products.  Licensee agrees not to develop derivative
works which are intended to be functionally equivalent substitutes for the
Software Products or any part thereof.  Licensee shall not modify, adapt,
translate, or create derivative works based on the Documentation without prior
written permission from GEMSTONE.

6.   COPY RESTRICTIONS
----------------------

6.1  Licensee shall not copy Software Products or Documentation except as
required for use of the Software Products as provided in this Agreement, and for
archival storage to assure against loss.  Licensee must reproduce and include
the
<PAGE>

GEMSTONE copyright notice and other proprietary notices on each archival copy.

7.   CONFIDENTIALITY
--------------------

7.1  Licensee understands and acknowledges that GEMSTONE has proprietary trade
secrets and confidential information in Software Products, and therefore will
hold the Software Products in confidence.

7.2  Notwithstanding anything in this Agreement, Licensee shall have no
obligation to hold any information in confidence to the extent that Licenses can
show by documentary evidence that such information:  (a) is already known to
Licensee at the time it is obtained by Licensee from GEMSTONE, free from any
obligation to hold such information in confidence; (b) is or becomes publicly
known through no wrongful act of Licensee; (c)is rightfully received from a
third party without restriction and without breach  of any obligation to
GEMSTONE or its suppliers; or (d) is independently developed by Licensee without
use of any confidential information of GEMSTONE or its suppliers.

7.3  Information regarding performance of the Software Products received from
GEMSTONE or developed by Licensee shall be maintained by Licensee as GEMSTONE
confidential information and Licensee shall not disclose such information to any
outside entity, including, but not limited to, industry analysts, trade press,
GEMSTONE's competitors, or other business entities without GEMSTONE's prior
written consent.

7.4  Licensee's obligations under this Section 7 shall survive termination of
this Agreement.

8.   PAYMENT
------------

8.1  Full payment is due within 30 days from the date of mailing an invoice for
the Software Products or Documentation to Licensee.  All amounts are payable in
U.S. Dollars by check or money order payable to GemStone Systems, Inc.  All
Taxes, if any, are to be paid by Licensee, except for taxes on the income or
revenue of GEMSTONE.

9.   TERM AND TERMINATION
-------------------------

9.1  The term of this Agreement shall commence on the effective date of this
Agreement and shall continue until terminated pursuant to this Section 9.

9.2  Either party may, by written notice, terminate this Agreement if the other
party fails to remedy any default under this Agreement within thirty (30) days
of receipt of written notice specifying such default.

9.3  Upon termination of this Agreement for any reason, all licenses granted
hereunder shall terminate, Licensee shall immediately cease use of and shall
return to GEMSTONE all copies of the Software Products and Documentation.

10.  SHIPMENT
-------------

10.1 GEMSTONE shall ship Software Products or Documentation ordered by Licensee
as soon as practical after acceptance of Licensee's order. All shipments of
Software Products and Documentation shall be F.O.B. Beaverton, OR, and the risk
of loss shall pass to Licensee upon delivery to the carrier. When an order is
not accompanied by shipping instructions, GEMSTONE shall select the carrier. In
no case shall GEMSTONE assume any liability in connection with the shipment nor
shall the carrier be construed as an agent for GEMSTONE. GEMSTONE shall not be
liable for any damages or penalties for delivery delays due to causes beyond its
reasonable control. All shipping, handling, and insurance charges, if any are to
be paid by Licensee.

10.2 Each order paced by Licensee for Software Products or Documentation shall
be deemed to incorporate all of the terms and conditions of this Agreement. Any
terms and conditions of such order which are in addition to or inconsistent with
the terms of this Agreement shall be deemed stricken from such order.

11.  SUPPORT
------------

11.1 GEMSTONE will deliver to Licensee any updates to the Software Products and
Documentation released for general availability during the 90 days following the
effective date of this Agreement, provided full payment of all license fees due
under this Agreement has been received by GEMSTONE. GEMSTONE will, for the 90
days following the effective date of this Agreement, as is reasonable, assist
Licensee by receiving telephone calls from Licensee at telephone number (503)
629-8383 (or such other telephone number as may be established for this purpose
from time to time by GEMSTONE) and communicating data to Licensee via electronic
mail to answer a reasonable number of questions about Software Products and
Documentation. GEMSTONE shall not be obligated to assist Licensee other than as
specified herein. After the initial 90 day period, continued updates and support
will be the subject of a separate Software Maintenance Agreement.

12.  WARRANTY; LIMITATION OF LIABILITY
--------------------------------------

12.1 GEMSTONE warrants that Software Products will perform substantially in
accordance with the Documentation for a period of ninety (90) days after the
date the Software Products have been shipped to Licensee (hereinafter "Warranty
Period").

12.2 During the Warranty Period, GEMSTONE shall attempt, without charge, to
diagnose, verify and correct errors or defects in the Software Products that are
identified in writing by notice to GEMSTONE, and any corrections for errors or
defects may, at GEMSTONE's election, be installed directly and/or incorporated
in subsequent updates to be delivered to Licensee from GEMSTONE.

12.3 Any modifications or other alterations of a Software Product by Licensee
without the approval of GEMSTONE shall, without limiting GEMSTONE's other
remedies, void GEMSTONE's warranty and software maintenance obligations unless
and until the Software Product is returned to its unaltered state.

12.4 GEMSTONE shall have no responsibility for delivering to Licensee any
subsequent versions of the Software products or Documentation that it may
develop in the future.

12.5 GEMSTONE's liability to the Licensee for all damages, costs, claims, or
demands incurred or suffered by or awarded against GEMSTONE arising directly or
indirectly out of the performance or any breach of this license shall in no
event exceed the total amount paid to GEMSTONE under this License.

12.6 THIS WARRANTY IS IN LIEU OF ALL OTHER WARRANTIES AND CONDITIONS, EXPRESSED
OR IMPLIED, INCLUDING BUT NOT LIMITED TO, ANY WARRANTY OF MERCHANTABILITY AND
FITNESS FOR A PARTICULAR PURPOSE.  EXCEPT AS MAY BE OTHERWISE PROVIDED IN THIS
AGREEMENT, GEMSTONE SHALL NOT BE RESPONSIBLE TO LICENSEE OR TO ANY THIRD PARTY
FOR ANY INDIRECT, SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES,
<PAGE>

WHETHER IN CONTRACT OR TORT, DUE TO ANY FORESEEN OR UNFORESEEN CAUSE FROM
LICENSEE'S OR ANY THIRD PARTY'S USE OR THE PERFORMANCE OF THE SOFTWARE PRODUCTS
UNDER THIS AGREEMENT.

13.   INDEMNITY BY GEMSTONE
---------------------------

13.1  GEMSTONE agrees to indemnify Licensee, as limited by this paragraph, with
respect to any suit, claim or proceeding brought against Licensee alleging that
Licensee's use of the Software Products constitutes an infringement of any valid
United States patent or copyright. GEMSTONE agrees to defend Licensee against
any such claims and to pay litigation costs, reasonable attorney's fees, and
damages awarded by a court of competent jurisdiction: if, and only if, Licensee
promptly gives notice to GEMSTONE of any such suit, claim or proceeding and
cooperates with GEMSTONE in the defense or settlement of such suit, claim or
proceeding; and provided that GEMSTONE shall have sole control thereof.

13.2  If a claim or allegation is made, or in either party's judgment is likely
to arise, Licensee agrees that GEMSTONE may, at GEMSTONE's option:

(i)   procure for Licensee the right to continue using the portion of the
Software Product enjoined from use;

(ii)  replace or modify the Software Product so that Licensee's use is not
subject to any such injunction; or

(iii) accept return of the Software Product to GEMSTONE, and in the event of
such return, GEMSTONE shall refund the license fee paid for the Software
Product.

GEMSTONE shall have no further liability or obligations arising from patents of
copyrights  under this Agreement.

13.3  This indemnity of section 13 shall not apply to claims arising from any
Software Product that has been modified or altered other than by GEMSTONE.

14.   INDEMNITY BY LICENSEE
---------------------------

14.1  Because GEMSTONE has no knowledge of, or control over, the applications of
the Software Products made by Licensee, and is therefore unable to assess any
risks of personal injury or damage arising from the applications made by
Licensee, Licensee assumes all risks, and agrees to indemnify GEMSTONE, and hold
GEMSTONE harmless, with respect to any suit, claim or proceeding brought against
GEMSTONE alleging that use by, or under authority of, Licensee, of the Software
Products caused personal injury or property damage.

15.   GENERAL
-------------

15.1  This agreement may be amended only by a written instrument stating an
intention to modify this Agreement and signed by a duly authorized
representative of the party to be bound.

15.2  Failure by either party at any time to require performance by the other
party or to claim a breach of any term or condition of this Agreement shall not
be construed as affecting any subsequent breach or the right to require
performance with respect thereto or to claim a breach with respect thereto.

15.3  This Agreement may not be assigned by either party without the prior
written permission of the other party, which permission shall not be
unreasonably withheld.

15.4  If any provision in this Agreement may be held to be invalid or
unenforceable in any jurisdiction in which this Agreement is being performed,
the meaning of such provision shall be construed so as to render it enforceable
to the extent feasible. If no feasible interpretation would save such provision,
it shall be severed from this Agreement and the remainder shall remain in full
force and effect. However, in the event such provision is considered an
essential element of this Agreement, the parties shall promptly negotiate
alternative, reasonable equivalent, enforceable terms.

15.5  The rights and obligations of the parties and all interpretations and
performance of this Agreement shall be governed in all respects by the laws of
the State of Oregon.

15.6  Notices shall be transmitted in writing by certified U.S. Mail, postage
prepaid, return receipt requested, addressed to the parties at an address
specified on the face page of this Agreement or to such other address as is
provided by notice.

15.7  Any notice given pursuant to Paragraph 15.6 shall be effective four (4)
days after the day it is mailed or upon receipt as evidenced by the U.S. Postal
Service return receipt card, whichever is earlier.

15.8  Section heading are inserted for convenience only and shall not be used in
any way to construe the terms of this Agreement.

The terms and conditions appearing on the face page and in the Software License
Agreement set forth the entire agreement between the parties. By executing this
Agreement, I acknowledge that I have read and understand all these terms and
conditions, and that I have the authority to enter into this Agreement on behalf
of the Licensee. This Agreement shall be effective as of the last date given
below.

LICENSEE:

/s/ D. M. Fisher     3/28/96
-------------------------------------
Authorized Signature/Date

Donal M. Fisher
-------------------------------------
Print Name

V.P. Sales & Marketing
-------------------------------------
Title

GEMSTONE:

_____________________________________
Authorized Signature/Date

_____________________________________
Print Name

_____________________________________
Title
<PAGE>

                        SOFTWARE MAINTENANCE AGREEMENT

DEFINITIONS:  As used herein, the terms set forth below shall have the following
respective meanings: "Designated Contact Person" shall mean the Primary Contact
or Alternate contact identified on the face page of this Agreement, either of
which may be changed upon written notice from licensee, who shall be responsible
for Service Request on behalf of all users at Licensee's site. "Software Update"
shall mean any change to Software Products or documentation, by GEMSTONE, for
the purpose or providing enhancements, improving performance, or improving
functionality; and that is formally released by GEMSTONE for external use.
"Service Request" shall mean communication from a Designated contact person to
GEMSTONE via telephone call, facsimile transmission, electronic mail for the
purpose of obtaining answers to questions about Software Products or
Documentation, or submitting problem reports about Software Products or
Documentation.

UPDATES:  GEMSTONE will promptly deliver to Licensee any Software Update issued
during the term of this Agreement, whereupon such Software Update shall be
regarded as the Software Product which it supersedes and shall there upon be
subject to all of the terms and conditions of this Software License Agreement
relating to such Software Product. Upon issue of any Software Update, it shall
become the currently supported version. Support for the version of the Software
Product it superseded will continue, but support for all previous versions will
be discontinued.

SUPPORT:  GEMSTONE will, as is reasonable, assist Licensee by receiving Service
Request from Licensee during normal GEMSTONE Business hours (9:00 a.m. - 6:00
p.m. Pacific time excluding weekends and holidays), and at phone numbers and
addresses to be made known to Licensee on the effective date of this Agreement.
In the case that Service Requests are questions posed by Licensee, GEMSTONE's
response shall be made within a reasonable time and shall include the answers,
if known. In the case that Service Requests are problem reports submitted by
Licensee, Licensee shall submit sufficient documentation of each problem
referenced therein to enable GEMSTONE to reproduce and verify same. GEMSTONE's
response to each problem shall be made within a reasonable time after it
verifies same, and may include (I) instructions for fixing or avoiding the
problem if known or readily ascertainable, or (II) a Software Update which is
free of such problem. GEMSTONE shall not be obligated to assist Licensee beyond
the assistance specified herein. Additional services such as complete
installation, onsite support, support outside of normal business hours, or
consulting are available at GEMSTONE's standard time and expense rates.

TERM:  The term of this Agreement shall commence on the effective date of this
Agreement and shall end one (1) year thereafter unless earlier terminated as
provided herein below. GEMSTONE shall have the right to terminate this Agreement
upon written notice to Licensee if Licensee is in Breach of any terms or
conditions of this Agreement, does not pay for renewal within 30 days after the
beginning of any renewal term, has any act of dissolution or bankruptcy made or
filed by or against it, makes any assignment of its assets for the benefit of
creditors, or has any substantial attachment or execution of judgment made
against it.

RENEWAL:  This agreement will be automatically renewed for an additional term at
the end of the current term unless (I) Licensee requests cancellation at least
30 days prior to the end of the current term, (II) GEMSTONE submits a different
Agreement to Licensee at least 30 days prior to the end of the current term,
(III) GEMSTONE has terminated this Agreement as specified above. The effective
date of the renewal Agreement shall be on the anniversary of the effective date
of this Agreement. Should Licensee decide to terminate this Agreement, renewal
at a later date may be purchased for the then current maintenance agreement
price plus a renewal fee equal to a one year's maintenance agreement price.

Signed:  /s/ D.M. Fisher
       --------------------

Date:  3/28/96
     ----------------------

Software License Agreement                  GemStone Systems, Inc.
<PAGE>

                        SOFTWARE MAINTENANCE AGREEMENT

DEFINITIONS:  As used herein, the terms set forth below shall have the
following respective meanings: "Designated Contact Person" shall mean the
Primary Contact or Alternate contact identified on the face page of this
Agreement, either of which may be changed upon written notice from licensee, who
shall be responsible for Service Request on behalf of all users at Licensee's
site. "Software Update" shall mean any change to Software Products or
documentation, by GEMSTONE, for the purpose or providing enhancements, improving
performance, or improving functionality; and that is formally released by
GEMSTONE for external use. "Service Request" shall mean communication from a
Designated contact person to GEMSTONE via telephone call, facsimile
transmission, electronic mail for the purpose of obtaining answers to questions
about Software Products or Documentation, or submitting problem reports about
Software Products or Documentation.

UPDATES:  GEMSTONE will promptly deliver to Licensee any Software Update issued
during the term of this Agreement, whereupon such Software Update shall be
regarded as the Software Product which it supersedes and shall there upon be
subject to all of the terms and conditions of this Software License Agreement
relating to such Software Product. Upon issue of any Software Update, it shall
become the currently supported version. Support for the version of the Software
Product it superseded will continue, but support for all previous versions will
be discontinued.

SUPPORT:  GEMSTONE will, as is reasonable, assist Licensee by receiving Service
Request from Licensee during normal GEMSTONE Business hours (9:00 a.m. - 6:00
p.m. Pacific time excluding weekends and holidays), and at phone numbers and
addresses to be made known to Licensee on the effective date of this Agreement.
In the case that Service Requests are questions posed by Licensee, GEMSTONE's
response shall be made within a reasonable time and shall include the answers,
if known. In the case that Service Requests are problem reports submitted by
Licensee, Licensee shall submit sufficient documentation of each problem
referenced therein to enable GEMSTONE to reproduce and verify same. GEMSTONE's
response to each problem shall be made within a reasonable time after it
verifies same, and may include (I) instructions for fixing or avoiding the
problem if known or readily ascertainable, or (II) a Software Update which is
free of such problem. GEMSTONE shall not be obligated to assist Licensee beyond
the assistance specified herein. Additional services such as complete
installation, onsite support, support outside of normal business hours, or
consulting are available at GEMSTONE's standard time and expense rates.

TERM:  The term of this Agreement shall commence on the effective date of
this Agreement and shall end one (1) year thereafter unless earlier terminated
as provided herein below. GEMSTONE shall have the right to terminate this
Agreement upon written notice to Licensee if Licensee is in Breach of any terms
or conditions of this Agreement, does not pay for renewal within 30 days after
the beginning of any renewal term, has any act of dissolution or bankruptcy made
or filed by or against it, makes any assignment of its assets for the benefit of
creditors, or has any substantial attachment or execution of judgment made
against it.

RENEWAL:  This agreement will be automatically renewed for an additional term at
the end of the current term unless (I) Licensee requests cancellation at least
30 days prior to the end of the current term, (II) GEMSTONE submits a different
Agreement to Licensee at least 30 days prior to the end of the current term,
(III) GEMSTONE has terminated this Agreement as specified above. The effective
date of the renewal Agreement shall be on the anniversary of the effective date
of this Agreement. Should Licensee decide to terminate this Agreement, renewal
at a later date may be purchased for the then current maintenance agreement
price plus a renewal fee equal to a one year's maintenance agreement price.

Signed:  /s/ D.M. Fisher                         /s/ Dan J. Ware
       -----------------

Date:  6/28/96                                     7/16/96
     -------------------

Software License Agreement                  GemStone Systems, Inc.
<PAGE>

            GEMSTONE SYSTEMS, INC. VALUE-ADDED REMARKETER AGREEMENT

This Agreement is made by and between GemStone Systems, Inc ("GEMSTONE"), an
Oregon corporation, and the Licensee, each being identified and having a place
of business as given on the face page of this Agreement.

BACKGROUND
----------

This Agreement is made with reference to the following facts:

     Licensee has entered into a GemStone Systems, Inc. Domestic Software
     License Agreement ("SLA"), to which this Agreement is attached, relating to
     the license of certain Software Products and Documentation identified on
     the face page of such agreement;

     The parties desire to add to the terms of the SLA in order that GEMSTONE
     may grant to Licensee a license to distribute the Software Products and
     Documentation upon the terms and conditions of this Agreement;

Now, therefore, the parties hereby agree as follows:

1.   DEFINITIONS
----------------

1.1  The definitions established in Section 1 of the SLA shall also apply to
this Agreement.

1.2  "Customer" means any end user to whom licensee sublicenses Documentation or
an executable copy of the Software Products.

1.3  "Territory" means the countries and areas identified on Exhibit B.

1.4  "Sublicense Agreement" means a contact between Licensee and a Customer
whereby the Customer is granted the right to use all or a part of the Software
Products and Documentation, and which contains the terms specified in Exhibit A.
Licensee may only sublicense the Software Products and Documentation to
Customers located in, and solely for use in, the Territory and may not
sublicense directly or indirectly to Customers in, or for use in, any other
countries.

2.   SUBLICENSE GRANT
---------------------

2.1  Notwithstanding the provisions of Section 2.1 of the SLA, GEMSTONE grants
license a non-exclusive, nontransferable, license to sublicense Customers
located in the Territory to use the Documentation and an executable version of
the Software Products, provided that:

     (i)   the Software Products and Documentation are part of a software
     product to be licensed by Licensee to a Customer;

     (ii)  the Software Products and Documentation are sublicensed for use only
     in the Territory;

     (iii) Licensee has its Customer execute a Sublicense Agreement containing a
     clear statement of the terms specified in Exhibit A in a manner enforceable
     in the Territory; and

     (iv)  Licensee shall affix on and encode in each copy of a Software Product
     sublicensed by Licensee a unique serial number provided by GEMSTONE.

3.   TERM
---------

This Agreement shall commence immediately and shall continue for a period of 2
years, unless sooner terminated as provided hereunder.

4.   FEES, PAYMENT REPORTS
--------------------------

4.1  Within thirty (30) days after the end of each calendar quarter, Licensee
shall remit payment of the appropriate Sublicense Fees as set forth in Exhibit
C.

     (i)   The Sublicense Fees set forth in Exhibit C may be changed by GEMSTONE
     at any time. If a change to a price, discount, payment or credit term
     results in an increase in cost to the Licensee, such change shall become
     effective only upon thirty (30) days prior written notice by GEMSTONE.

4.2  Within thirty (30) days after the end of each calendar quarter, Licensee
shall also deliver to GEMSTONE a written Activity Report signed by an officer of
Licensee covering the calendar quarter.  The Activity Report shall contain the
following information;

     (i)   the amount of the royalties or fees payable by Licensee to GEMSTONE
     for licenses or sublicense of the Software Products and Documentation
     during the preceding calendar quarter;

     (ii)  the manner in which the amount of the royalties or fees payable to
     GEMSTONE was calculated by Licensee;

     (iii) a description of the software products licensed by Licensee to
     Customers hereunder;

     (iv)  the date on which the Software Products were shipped to each end
     user;

     (v)   the brands and models of the Server Computer Systems on which the
     Software Products were installed; and

     (vi)  the unique serial number provided by GEMSTONE which was affixed to
     and encoded into each Software Product.

4.3  Licensee shall maintain accurate records relating to the copying,
distribution, sublicensing, and servicing of the Software Products and
Documentation so as to establish the payments due to GEMSTONE hereunder, to
identify all Sublicensees, and to otherwise verify Licensee's compliance with
the terms of this Agreement.  Such books, records and Sublicense Agreements
shall be available at their place of keeping for inspection or copying by
GEMSTONE or an independent auditor chosen and paid by GEMSTONE during normal
business hours.  Licensee shall retain all Sublicense Agreements and records
pertaining to payments due to GEMSTONE for a period of three (3) years after
termination.  In the event an audit reveals that Licensee has not paid all of
the Sublicense Fees due hereunder, Licensee shall pay within 10 days the
discrepancy plus interest, calculated at a monthly rate of 1% per month (or, the
maximum rate allowed by law, if less) from the date the Sublicense Fee was due
until it is paid.  If the discrepancy exceeds more than 5% of the Sublicense
Fees due for the period under audit, Licensee shall also reimburse the cost of
such inspection, including reasonable auditor's fees.

4.4  All sales, use, personal property, withholding and other taxes relating to
this Agreement shall be paid by Licensee unless Licensee provides GEMSTONE with
valid tax exemption certificates.  Licensee shall not be reasonable for taxes
based on GEMSTONE's net income.

4.5  Any Payment or part of a payment that is not paid when due shall bear
interest at the rate of 1.5% per month, or at the highest contract rate allowed
by law, whichever is less, from its due date until paid.
<PAGE>

5.   LICENSEE OBLIGATIONS
--   --------------------

5.1  Licensee shall evaluate and test the Software Products and Documentation to
determine its suitability for use in the creation of products.

5.2  Licensee agrees to train within sixty (60) days of the effective date of
this Agreement and maintain a sufficient number (minimum of one (1) each) of
capable technical and sales personnel to carry out the obligations and
responsibilities of Licensee under this Agreement.

5.3  Licensee shall provide all technical, service, warranty, return, telephone
and other training, service and support to its Customers relating to the
Software Products.

6.   SUPPORT
--   -------

6.1  Subject to the availability of its personnel, GEMSTONE will provide
reasonable technical assistance to Licensee, upon request, at GEMSTONE's then-
current rates, terms, and conditions.

7.   OWNERSHIP AND NOTICES
--   ---------------------

7.1  Licensee shall insure that any copyright notice or other proprietary rights
notice placed in or on or displayed by the Software products or Documentation by
GEMSTONE, whether in machine language or human readable form continue to appear
or exist in all copies of the Software Products and Documentation that Licensee
delivers to its Customers.

8.   INDEMNITY BY LICENSEE
--   ---------------------

8.1  Licensee shall indemnify GEMSTONE from all claims, losses, and damages
which may arise from its marketing, installation, or support of the Software
Products and Documentation, including claims based on representations,
warranties, or misrepresentations made by Licensee, inadequate installation,
support or assistance by licensee, or any other act or failure to act on the
part of Licensee.  Licenser shall have the right to participate in the defense
of any such claim at its own expense.

9.   TERMINATION
--   -----------

9.1  In addition to the provisions of Section 9 of the SLA, GEMSTONE may
terminate this Agreement prior to its expiration upon the failure of Licensee to
pay any sum due hereunder within fifteen (15) days of the date due.

9.2  Licensee may terminate this Agreement at any time after all payments
accrued hereunder prior to the effective date of termination have been made by
giving ninety (90) days written notice to GEMSTONE.

9.3  In addition to its obligations under Section 9.3 of the SLA, upon
expiration or termination of this Agreement, Licensee agrees to cease
sublicensing the Software Products and Documentation.  Notwithstanding the
foregoing, and notwithstanding termination of this Agreement, Licensee shall
retain the right to continue to support authorized Customer copies of Software
products that have been sublicensed hereunder prior to the effective date of
termination, subject to continued payment of applicable royalties to GEMSTONE.

10.  GENERAL
---  -------

10.1 This Agreement may not be assigned by either party without the prior
written approval of the other party, which approval shall not be unreasonably
withheld.

10.2 Each party is acting as an independent contractor and not as an agent,
partner, or joint venturer with the other party for any purpose.  Except as
provided in this Agreement, neither party shall have any right, power, or
authority to act or to create any obligation, express or implied, on behalf of
the other.

10.3 Neither GEMSTONE nor Licensee shall be reasonable for delays or failure of
performance resulting from acts beyond the reasonable control of such party.
Such acts shall include, but not be limited to, acts of god, strikes, walkouts,
riots, acts of war, epidemics, failure of suppliers to perform, governmental
regulations, power failure or failures, earthquakes, or other disasters.

10.4 The parties have read this Agreement and agree to be bound by its terms,
and further agree that this Agreement, together with the SLA of which it is a
part, constitute the complete and exclusive statement of the agreement between
them which supersedes all proposals, oral or written, and all other
communications between them relating to the license and use of the Software
Products and Documentation.

In witness whereof, the parties have caused this Agreement to be executed by
their duly authorized representatives.

LICENSEE:

 /s/ D.M. Fisher
------------------------------------------
Authorized Signature/Date

  Donald Fisher
------------------------------------------
Print Name

  V.P. Sales & Marketing
------------------------------------------
Title

GEMSTONE:

 /s/ Dan J. Ware
------------------------------------------
Authorized Signature/Date

  Dan J. Ware
------------------------------------------
Print Name

  Sr. V.P. W.W. Operations
------------------------------------------
Title
<PAGE>

       Addendum to GemStone Systems, Inc. Value Added Reseller Agreement
       -----------------------------------------------------------------

This addendum is hereby made part of and incorporated into the GemStone Systems,
Inc. Value Added Reseller ("Agreement") entered into by and between GemStone
Systems, Inc. ("GemStone") and Genomica ("Licensee") on April 8, 1996.  In the
event that this Addendum is inconsistent or conflicting with Agreement, the
provisions of the Addendum will prevail.

The parties agree to make the following changes to the Agreement.

Paragraph 2 - SUBLICENSE GRANT
------------------------------

Delete the following:

     (iv)  Licensee shall affix on and encode in each copy of a Software Product
sublicensed by Licensee a unique serial number provided by GEMSTONE

Paragraph 4 - FEES, PAYMENT REPORTS
-----------------------------------

Section 4.1, (i) shall read as follows:

     (i)  The Sublicense Fees set forth in Exhibit C may be changed by GEMSTONE
     at any time. If a change to a price, discount, payment or credit term
     results in an increase in cost to the Licensee, such change shall become
     effective only upon ninety (90) days prior written notice by GEMSTONE.

Section 4.2, (v) shall read as follows:

     (v)  the platform and operating systems of the Server Computer Systems on
     which the Software Products were installed; and

Add the following section (vi):

     (v)  GEMSTONE acknowledges that the information provided by Licensee under
     section 4.2 and 4.3 is confidential to Licensee and will treat it as such
     provided however, such information is marked confidential with a
     appropriate legend or stamp.

Paragraph 6 -  SUPPORT
----------------------

Add the following sentence:

     GemStone anticipates providing such service in accordance with its standard
     response and escalation procedures.

Paragraph 8 - INDEMNITY BY LICENSEE
-----------------------------------

Add the following sentence to the end of the paragraph:

     The foregoing indemnity obligation of Licensee shall not apply with respect
     to any claims that the Software Products infringe upon any patent or
     copyright, and such claims shall be subject to GEMSTONE's indemnity
     obligations under the SLA, except to the extent that such claims relate to
     any modification or alteration of a Software Product by a party other than
     GEMSTONE or the use of a Software Product with any materials not provided
     by GEMSTONE.
<PAGE>

Paragraph 9 - TERMINATION
-------------------------

Section 9.1 shall read as follows:

     In addition to the provisions of section 9 of the SLA. GEMSTONE may
     terminate this Agreement prior to its expiration upon the failure of
     Licensee to pay any sum due hereunder within thirty (30) days of the date
     due.

IN WITNESS WHEREOF, the undersigned have read and agreed to the terms of this
Agreement.

GEMSTONE SYSTEMS, INC.                      Genomica

By: /s/ Dan J. Ware                         By: /s/ D. M. Fisher
   --------------------------------            --------------------------------

Name:   Dan J. Ware                         Name:   Donald M. Fisher
     ------------------------------              ------------------------------

Title:  Sr. V.P. W.W. Operation             Title:  V.P. Sales & Marketing
      -----------------------------               -----------------------------

Date:   5/1/96                              Date:   4/8/96
     ------------------------------              ------------------------------

03/27/96; 12:18 PM

<PAGE>

                                   EXHIBIT A

                    Terms Required in Sublicense Agreement

The parties agree that each Sublicense Agreement between licensee and its
Customers for the Software Products and Documentation shall require that the
Customer agree to the following:

Title to the Software Products does not pass to the Customer.

Customer only obtains a non-exclusive license, without right to sublicense, to
use the Software Products in the Territory to access a single Logical GemStone
Database on Server Computer Systems.

Customer shall not transfer or license the use of all or any portion of the
Software Products and Documentation to any third party or entity.

The Software Products constitutes highly valuable property of GEMSTONE and
contains trade secrets and confidential information owned by GEMSTONE.  Customer
shall observe complete confidentiality with respect to the Software Products and
documentation, and all performance data and shall not disclose all or any
portion thereof to any third party or entity, except to its employees as
required in the course of their employment.

Customer shall not decompile, disassemble or otherwise reverse engineer the
Software Products.

The obligations set forth above shall survive any expiration of the term of the
Sublicense Agreement.

GEMSTONE has made no representations to the Customer and GEMSTONE warrants only
that the Software Products will perform substantially in accordance with the
documentation for a period of ninety (90) days.

GEMSTONE's liability to Customer for any claim shall be limited to direct
damages and shall not exceed the total amount paid to GEMSTONE for the license
of the Software Products.
<PAGE>

                                   EXHIBIT B

                                   Territory

The geographic scope of the licenses conveyed herein by GEMSTONE to VAR for
Genomica's product called Genome topographer shall be World Wide distribution.
<PAGE>

                                   EXHIBIT C

                                Sublicense Fees

1.  Licenses Product:  Genome Topographer (GT)
                       -----------------------

    Fee: Licensee will remit to GemStone a royalty equal to 14% of gross sales
    received in connection with the sale and distribution of concurrent users
    for the above product. Amounts subject to the royalty include product
    licenses and maintenance fees and as such will allow Licensee to updates its
    VAR product and distribute to its Customers.

    Number of Users:  The above product is sold on a per user bases.

    Term of Licensee Product: One year. Subsequent renewals fees will be
    remitted at the above percentage on an annual basis. Should customer elect
    to cease using GT during the annual term, no fees paid will be refunded to
    Licensee.

2.  Evaluation Licenses:

GEMSTONE acknowledges the need for Genomica to conduct evaluations of the GT
with its prospects.  Therefore, GEMSTONE will grant at Genomica's request a
thirty (30) day temporary keyfile in order to access the GEMSTONE Software at no
charge to accommodate the Genomica evaluation cycle.
<PAGE>

                                   EXHIBIT D

                            Approved Configurations

1.   Licensee Product:
     ----------------

Name of Product(s): Genome Topographer (GT)

Brief Description and function: The Genome Topographer supports computer aided
gene analysis.

2.   Approved Configuration
     ----------------------

Platform/Operating systems: Any GemStone supported platform

Language Interfaces: GemStone Smalltalk Interface for Visual Works, GemStone C
Interface

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