Document:

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<P align="center">
<B><FONT size="2">COMMON STOCK OPTION AGREEMENT</FONT></B>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">STOCK OPTION AGREEMENT, dated as of
August&nbsp;2, 2003, by and among Ascential Software
Corporation, a Delaware corporation (&#147;Parent&#148;), Greek
Acquisition Corporation, a Delaware corporation and a
wholly-owned subsidiary of Parent (the &#147;Purchaser&#148;),
and Mercator Software, Inc., a Delaware corporation (the
&#147;Company&#148;).
</FONT>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">WHEREAS, the Company, Parent and the Purchaser
are entering into an Agreement and Plan of Merger (the
&#147;Merger Agreement&#148;) of even date herewith providing
for (i)&nbsp;a cash tender offer to purchase any and all
outstanding shares of Common Stock, par value $0.01 per share,
of the Company (the &#147;Common Shares&#148;), at a price of
$3.00 per share, net to the seller in cash upon the terms and
subject to the conditions set forth in the Merger Agreement (the
&#147;Offer&#148;); and (ii)&nbsp;the merger (the
&#147;Merger&#148;) of the Purchaser into the Company; and
</FONT>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">WHEREAS, as a condition to the willingness of
Parent and the Purchaser to enter into the Merger Agreement and
commence the Offer, Parent and Purchaser have requested, and the
Company has agreed to grant the Purchaser, the option to
purchase, as described herein, authorized but unissued Common
Shares.
</FONT>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">NOW THEREFORE, in consideration of the foregoing
and the mutual covenants and agreements set forth herein, and
for other good and valuable consideration the sufficiency of
which is hereby acknowledged, the parties agree as follows:
</FONT>
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    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Grant of
    Option.</I> On the terms and subject to the conditions of this
    Agreement, the Company hereby grants to the Purchaser an
    irrevocable option (the &#147;Option&#148;) to purchase for the
    Offer Price as defined in the Merger Agreement (the
    &#147;Purchase Price&#148;) no more than 19.99% of the then
    outstanding Common Shares in the aggregate (collectively, the
    &#147;Optioned Shares&#148;).
    </FONT></TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Exercise of
    Option.</I> Subject to the immediately succeeding sentence, the
    Option may be exercised by the Purchaser, in whole or in part,
    at any time or from time to time after Purchaser has purchased
    Shares pursuant to the Offer until the earlier of
    (i)&nbsp;immediately following the Effective Time (as defined in
    the Merger Agreement) and (ii)&nbsp;the termination of the
    Merger Agreement in accordance with its terms. The exercise of
    the Option for Common Shares is conditioned upon the Purchaser
    and the Parent owning, immediately following such exercise, in
    the aggregate, at least 90% of the outstanding Common Shares. In
    the event the Purchaser wishes to exercise the Option, the
    Purchaser shall give a written notice (the &#147;Notice&#148;)
    to the Company of its intention to exercise the Option,
    specifying the number of Optioned Shares to be purchased. Such
    notice shall be delivered to the Company in accordance with the
    requirements of Section&nbsp;7(d), and shall specify a date
    (which may be the date of such notice) not more than ten
    business days from the date such Notice is given for the
    purchase of the Optioned Shares. The closing (the
    &#147;Closing&#148;) of the purchase of the Optioned Shares
    shall take place at the offices of Skadden, Arps, Slate,
    Meagher&nbsp;&#38; Flom LLP, One Beacon Street, Boston,
    Massachusetts 02108 or at such other location as the Purchaser
    shall elect. If any decree, injunction, order, law or regulation
    shall not permit the purchase of the Optioned Shares to be
    consummated on the date specified in such Notice, the date for
    the Closing shall be as soon as practicable following the
    cessation of such restriction on consummation, but in any event
    within two business days thereof.
    </FONT></TD>
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    <TD>&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Payment and
    Delivery of Certificate(s).</I> At any Closing hereunder,
    (a)&nbsp;the Purchaser shall make payment to the Company of the
    aggregate price for the par value of the Optioned Shares so
    purchased in official bank check or by wire transfer to a bank
    designated by the Company; (b)&nbsp;the Purchaser shall deliver
    to the Company a Promissory Note substantially in the form
    attached hereto as <I>Exhibit&nbsp;A</I> (the &#147;Note&#148;)
    for the aggregate price for the Optioned Shares so purchased
    less the amount paid in accordance with clause&nbsp;3(a); and
    (c)&nbsp;the Company shall deliver to the Purchaser a
    certificate or certificates representing the number of Optioned
    Shares so purchased registered in the
    </FONT></TD>
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<P align="center"><FONT size="2">1
</FONT>

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    <FONT size="2">name of the Purchaser. Certificates for Optioned
    Shares delivered at the Closing may be endorsed with a
    restrictive legend that shall read substantially as follows:
    </FONT></TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">&#147;THE SECURITIES OFFERED HEREBY ARE SUBJECT
    TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE
    TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE SECURITIES
    ACT OF 1933 AND APPLICABLE STATE SECURITIES LAWS, PURSUANT TO
    REGISTRATION OR EXEMPTION THEREFROM.&#148;
    </FONT></TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">It is understood and agreed that the reference to
    the resale restrictions of the Securities Act of 1933 in the
    above legend shall be removed by delivery of substitute
    certificate(s) without such reference if Parent shall have
    delivered to the Company a copy of a letter from the staff of
    the Securities and Exchange Commission, or an opinion of counsel
    reasonably satisfactory to the Company, to the effect that
    registration of the future resale of the Optioned Shares is not
    required and that such legend is not required for purposes of
    the Securities Act.
    </FONT></TD>
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    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Representations
    and Warranties of the Company.</I> The Company hereby represents
    and warrants (such representations and warranties being deemed
    repeated at and as of any Closing hereunder) to Parent and the
    Purchaser as follows:
    </FONT></TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(a)&nbsp;<I>Due Incorporation.</I> The Company is
    a corporation duly organized, validly existing and in good
    standing under the laws of the State of Delaware and has the
    requisite corporate power and authority to enter into and
    perform this Agreement.
    </FONT></TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(b)&nbsp;<I>Due Authorization, etc.</I> This
    Agreement and the consummation of the transactions contemplated
    hereby have been duly authorized by all necessary corporate
    action on the part of the Company. This Agreement has been duly
    executed and delivered by a duly authorized officer of the
    Company and constitutes the valid and binding obligation of the
    Company, enforceable against the Company in accordance with its
    terms.
    </FONT></TD>
</TR>

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    <TD>&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(c)&nbsp;<I>Company&#146;s Capital Stock.</I> The
    Company has taken all necessary corporate action to authorize
    and reserve for issuance upon exercise of the Option the
    Optioned Shares, and at all times from the date hereof through
    the date of termination of this Agreement will keep reserved for
    issuance upon exercise of the Option the number of Common Shares
    that the Purchaser is then entitled to purchase pursuant to the
    Option. The Common Shares to be issued upon due exercise, in
    whole or in part, of the Option shall, when issued, be validly
    issued, fully-paid and non-assessable, and shall be delivered
    free and clear of all claims, liens, encumbrances and security
    interests, including any preemptive right of any of the
    stockholders of the Company.
    </FONT></TD>
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    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">5.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Representations
    and Warranties of the Purchaser and Parent.</I> Parent and the
    Purchaser hereby jointly and severally represent and warrant
    (such representations and warranties being deemed repeated at
    and as of any Closing hereunder) to the Company as follows:
    </FONT></TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(a)&nbsp;<I>Due Incorporation.</I> Each of Parent
    and the Purchaser is a corporation duly organized, validly
    existing and in good standing under the laws of the State of
    Delaware and has the requisite corporate power and authority to
    enter into and perform this Agreement.
    </FONT></TD>
</TR>

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    <TD>&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(b)&nbsp;<I>Due Authorization, etc.</I> This
    Agreement and the consummation of the transactions contemplated
    hereby have been duly authorized by all necessary corporate
    action on the part of the Purchaser and Parent. This Agreement
    has been duly executed and delivered by a duly authorized
    officer of the Purchaser and of Parent, and constitutes the
    valid and binding obligation of the Purchaser and of Parent,
    enforceable against each in accordance with its terms.
    </FONT></TD>
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    <TD>&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(c)&nbsp;<I>Distribution.</I> The Purchaser is
    acquiring the Option and will acquire the Optioned Shares to be
    purchased upon exercise of the Option for its own account and
    not with a view to the distribution thereof within the meaning
    of the Securities Act of 1933. The foregoing representation and
    warranty shall be made by any assignee under Section&nbsp;7(a)
    and shall be binding upon such assignee.
    </FONT></TD>
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<P align="center"><FONT size="2">2
</FONT>

<PAGE>
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    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">6.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Adjustment
    Upon Changes in Capitalization.</I> In the event of any change
    in the shares of the Company&#146;s capital stock by reason of
    any stock dividend, split-up, merger, recapitalization,
    combination, conversion, exchange of shares, issuance of shares
    (or agreements or commitments to issue shares) or the like, the
    number of Optioned Shares subject to the Option and the purchase
    price per Optioned Share shall be appropriately adjusted.
    </FONT></TD>
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    <TD>&nbsp;</TD>
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<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">7.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<I>Miscellaneous.</I>
    </FONT></TD>
</TR>

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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(a)&nbsp;<I>Assignment; Guarantee of the
    Purchaser&#146;s Obligations.</I> This Agreement shall not be
    assigned by the Purchaser, except to Parent or a wholly-owned
    subsidiary of Parent, without the prior written consent of the
    Company, which consent may be withheld, conditioned or delayed
    in the Company&#146;s sole and absolute discretion. Parent
    hereby unconditionally guarantees the full and punctual
    performance by Purchaser of all of the obligations of Purchaser
    or any of its assignees or delegates hereunder and under the
    Note. In connection with the obligations of Parent under the
    immediately preceding sentence, Parent hereby waives any and all
    rights, notices and defenses to which it otherwise would be
    entitled solely in its capacity as a guarantor under this
    Agreement or the Note.
    </FONT></TD>
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    <TD>&nbsp;</TD>
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<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(b)&nbsp;<I>Amendments.</I> This Agreement may
    not be modified, amended, altered or supplemented except upon
    the execution and delivery of a written agreement executed by
    the parties hereto.
    </FONT></TD>
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<TR>
    <TD>&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(c)&nbsp;<I>Non-survival of representations,
    etc.</I> All representations, warranties and agreements in this
    Agreement shall terminate at the Closing.
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(d)&nbsp;<I>Notices.</I> All notices, requests,
    claims, demands and other communications hereunder shall be in
    writing and shall be given (and shall be deemed to have been
    duly received if so given) by delivery, by cable, telegram or
    telex, or by mail (registered or certified mail, postage
    prepaid, return receipt requested) to the respective parties as
    follows:
    </FONT></TD>
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    <FONT size="2">If to the Company:
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Mercator Software, Inc.
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">45 Danbury Road
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Wilton, Connecticut
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Attention: General Counsel
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Facsimile: (203)&nbsp;563-1361
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">With a copy to:
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Jenkens &#38; Gilchrist Parker Chapin LLP
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">450 Lexington Avenue
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Chrysler Building
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">New York, New York 10023
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Attention: Michael Weinseir, Esq.
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Facsimile: (212)&nbsp;704-6288
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">If to Parent or the Purchaser:
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Ascential Software Corporation
    </FONT></TD>
</TR>

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    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">50 Washington Street
    </FONT></TD>
</TR>

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    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Westborough, MA 01581
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Attention: General Counsel
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Facsimile: (508)&nbsp;389-8711
    </FONT></TD>
</TR>

</TABLE>

<P align="center"><FONT size="2">3
</FONT>
<PAGE>
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    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">With copies to:
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Skadden, Arps, Slate, Meagher &#38; Flom LLP
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">One Beacon Street
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Boston, MA 02108
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Attention: Louis Goodman, Esq.
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Facsimile: (617)&nbsp;573-4822
    </FONT></TD>
</TR>

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    <FONT size="2">or to such other address as either party may have
    furnished to the other in writing in accordance herewith, except
    that notices of change of address shall be effective only upon
    receipt.
    </FONT></TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(e)&nbsp;<I>Governing Law.</I> This Agreement
    shall be governed by and construed in accordance with the
    substantive law of the State of Delaware without giving effect
    to the principles of conflict of laws thereof.
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(f)&nbsp;<I>Counterparts.</I> This Agreement may
    be executed in several counterparts, each of which shall be an
    original, but all of which together shall constitute one and the
    same agreement.
    </FONT></TD>
</TR>

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    <TD>&nbsp;</TD>
</TR>

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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(g)&nbsp;<I>Effect of Headings.</I> The Section
    headings herein are for convenience only and shall not affect
    the construction hereof.
    </FONT></TD>
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    <TD>&nbsp;</TD>
</TR>

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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(h)&nbsp;<I>Entire Agreement.</I> This Agreement
    constitutes the entire agreement among the parties with respect
    to the matters referred to herein and supersedes all prior
    agreements or understandings, both written or oral, among the
    parties, or any of them, with respect to the subject matter
    hereof.
    </FONT></TD>
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    <TD>&nbsp;</TD>
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    <TD>&nbsp;</TD>
    <TD align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <FONT size="2">(i)&nbsp;<I>Specific Performance.</I> Purchaser,
    Parent and the Company each acknowledge and agree that the other
    would be irreparably damaged in the event any of the provisions
    of this Agreement were not performed by it in accordance with
    the specific terms or were otherwise breached. The Company
    agrees that if for any reason the Company shall have failed to
    issue Optioned Shares or to perform any of its other obligations
    under the Agreement, then the Purchaser and Parent shall be
    entitled to specific performance and injunctive and other
    equitable relief and the Company agrees to waive any requirement
    for the securing or posting of a bond in connection with the
    obtaining of any such injunctive or other equitable relief. This
    provision is without prejudice to any other rights the Purchaser
    and Parent may have against the Company for any failure to
    perform its obligations under this Agreement.
    </FONT></TD>
</TR>

</TABLE>

<P align="center">
<FONT size="2">[Signature Page Follows]
</FONT>

<P align="center"><FONT size="2">4
</FONT>

<PAGE>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">IN WITNESS WHEREOF, Parent, the Purchaser and the
Company have caused this Company Stock Option Agreement to be
duly executed on the day and year first above written.
</FONT>
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    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">ASCENTIAL SOFTWARE CORPORATION
    </FONT></TD>
</TR>

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</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD><FONT size="2">By:&nbsp;</FONT></TD>
    <TD align="left">
    <FONT size="2">/s/ PETER GYENES
    </FONT></TD>
</TR>

</TABLE>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">

<TR>
    <TD width="40%"></TD>
    <TD width="60%"></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <HR size="1" align="left" noshade></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Name: Peter Gyenes
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Title: Chairman and Chief Executive Officer
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">GREEK ACQUISITION CORPORATION
    </FONT></TD>
</TR>

</TABLE>
<P>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">

<TR>
    <TD width="40%"></TD>
    <TD width="2%"></TD>
    <TD width="58%"></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD><FONT size="2">By:&nbsp;</FONT></TD>
    <TD align="left">
    <FONT size="2">/s/ PETER FIORE
    </FONT></TD>
</TR>

</TABLE>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">

<TR>
    <TD width="40%"></TD>
    <TD width="60%"></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <HR size="1" align="left" noshade></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Name: Peter Fiore
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Title: President
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">MERCATOR SOFTWARE, INC.
    </FONT></TD>
</TR>

</TABLE>
<P>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">

<TR>
    <TD width="40%"></TD>
    <TD width="2%"></TD>
    <TD width="58%"></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD><FONT size="2">By:&nbsp;</FONT></TD>
    <TD align="left">
    <FONT size="2">/s/ ROY C. KING
    </FONT></TD>
</TR>

</TABLE>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">

<TR>
    <TD width="40%"></TD>
    <TD width="60%"></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <HR size="1" align="left" noshade></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Name: Roy C. King
    </FONT></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">Title: Chairman and Chief Executive Officer
    </FONT></TD>
</TR>

</TABLE>

<P align="center">
<I><FONT size="2">Signature Page to Option Agreement</FONT></I>

<P align="center"><FONT size="2">5
</FONT>
<PAGE>

<P align="right">
<B><FONT size="2">Exhibit&nbsp;A</FONT></B>

<P align="center">
<B><FONT size="2">NON-TRANSFERABLE PROMISSORY NOTE</FONT></B>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">FOR VALUE RECEIVED, Greek Acquisition
Corporation, a Delaware corporation (&#147;the Maker&#148;),
hereby promises to pay to Mercator Software, Inc., a Delaware
Corporation, the principal amount of
[&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;]
($&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;)],
with no interest, on [insert date that is six months after the
date of exercise] by wire transfer of immediately available
funds to an account designated by the payee. The amount due
hereunder shall be payable in money of the United States of
America lawful at such time for the payment of public and
private debts.
</FONT>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">The Maker hereby waives presentment, diligence,
protest and demand, notice of protest, demand, dishonor and
nonpayment of this Note, and all other notices of any kind in
connection with the delivery, acceptance, performance, default
or enforcement of this Note.
</FONT>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">This Note shall be governed by and construed in
accordance with the laws of the State of Delaware without giving
effect to the principles of conflicts of laws thereof.
</FONT>

<P align="left">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<FONT size="2">IN WITNESS WHEREOF, the Maker has caused this
Note to be executed as of
the &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;day
of &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;,
2003.
</FONT>
<P>

<TABLE width="100%" border="0" cellpadding="0" cellspacing="0">

<TR>
    <TD width="40%"></TD>
    <TD width="60%"></TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">GREEK ACQUISITION CORPORATION
    </FONT></TD>
</TR>

<TR>
    <TD>&nbsp;</TD>
</TR>

<TR valign="top">
    <TD>&nbsp;</TD>
    <TD align="left">
    <FONT size="2">By:<HR size="1" align="left" noshade>
    </FONT></TD>
</TR>

</TABLE>

<P align="center"><FONT size="2">6
</FONT>Non-Exclusive License Agreement between U of M Med School and Co. covering RNA

 EXHIBIT 10.2 
  

Certain information marked by asterisks {***} in this Exhibit has been omitted pursuant to a request for confidential treatment. The omitted information has been filed
separately with the Securities and Exchange Commission. 
   
 NON-EXCLUSIVE LICENSE AGREEMENT 
  
 This Agreement,
effective as of April 15, 2003 (the “Effective Date”), is between the University of Massachusetts Medical School (“Medical School”), a public institution of higher education of the Commonwealth of Massachusetts having an address
of 55 Lake Avenue North, Worcester, MA 01655 and CytRx Corporation (“Company”), a Delaware corporation having an address of 11726 San Vicente Blvd., Suite 650, Los Angeles, CA 90049. 
  
 R E C I T A L S 
  
 WHEREAS, Medical School is owner by assignment of the invention claimed in
the United States Patent Application listed in Exhibit A pertaining to the Medical School’s invention disclosure number UMMC 01-36 entitled RNA Sequence-Specific Mediators of RNA Interference; 
  
 WHEREAS, Company desires to obtain a non-exclusive license in the field of
therapeutics limited to the narrowed fields of other Medical School license agreements; specifically, using RNAi to inhibit HCMV Immediate Early (IE) gene expression in Retinitis applications, using RNAi to inhibit mutant SOD1 gene expression in
Amytrophic Lateral Sclerosis (ALS) applications, and using RNAi to inhibit gene targets implicated in Type II Diabetes and Obesity under the rights of Medical School in any patent rights claiming those inventions; and 
  
 WHEREAS, Medical School is willing to grant Company a non-exclusive license
on the terms set forth in this Agreement. 
  
 NOW, THEREFORE,
Medical School and Company hereby agree as follows: 
  
 1. Definitions. 
  
 1.1.
“Affiliate” means any legal entity (such as a corporation, partnership, or limited liability company) that is controlled by Company. For the purposes of this definition, the term “control” means (a) beneficial ownership of
at least fifty percent (50%) of the voting securities of a corporation or other business organization with voting securities or (b) a fifty percent (50%) or greater interest in the net assets or profits of a partnership or other business
organization without voting securities. 
  
 1.2.
“Biological Materials” means the tangible biological materials described on Exhibit A, as well as tangible materials that are routinely produced through use of the original materials, including, for example, any progeny
derived from a cell line, monoclonal antibodies produced by hybridoma cells, DNA or RNA replicated from isolated DNA or RNA, recombinant proteins produced through use of isolated DNA or RNA, and substances routinely purified from a source material
included in the original materials (such as recombinant proteins isolated from a cell 

 
extract or supernatant by non-proprietary affinity purification methods). These Biological Materials shall be listed on Exhibit A, which will be periodically
amended to include any additional Biological Materials that Medical School may furnish to Company. 
  
 1.3. “Combination Product” means a product that contains a Licensed Product component and at least one other essential functional
component. 
  
 1.4. “Confidential Information”
means any confidential or proprietary information furnished by one party (the “Disclosing Party”) to the other party (the “Receiving Party”) in connection with this Agreement, provided that such information is specifically
designated as confidential. Such Confidential Information shall include, without limitation, any diligence reports furnished to Medical School under Section 3.1. and royalty reports furnished to Medical School under Section 5.2. 
  
 1.5. “Field” means therapeutics, prophylactics, and
diagnostics arising from the limited use of RNAi to inhibit HCMV Immediate Early (IE) gene expression in Retinitis applications, using RNAi to inhibit mutant SOD1 gene expression in Amyotrophic Lateral Sclerosis (ALS) applications, and using RNAi to
inhibit gene targets implicated in Type II Diabetes and Obesity. 
  
 1.6. “Licensed Product” means any product that cannot be developed, manufactured, used, or sold without (a) infringing one or more claims under the Patent Rights or (b) using or incorporating some portion of one or more
Biological Materials. 
  
 1.7. “Net Sales” means the
gross amount billed or invoiced on sales by Company and its Affiliates and Sublicensees of Licensed Products, less the following: (a) customary trade, quantity, or cash discounts and commissions to non-affiliated brokers or agents to the extent
actually allowed and taken; (b) amounts repaid or credited by reason of rejection or return; (c) to the extent separately stated on purchase orders, invoices, or other documents of sale, any taxes or other governmental charges levied on the
production, sale, transportation, delivery, or use of a Licensed Product which is paid by or on behalf of Company; (d) outbound transportation costs prepaid or allowed and costs of insurance in transit; and (e) allowance for bad debt that is
customary and reasonable for the industry and in accordance with generally accepted accounting principles. Notwithstanding anything to the contrary in this Section 1.7, Net Sales does not include sales of Licensed Products at or below the fully
burdened cost of manufacturing solely for research or clinical testing or for indigent or similar public support or compassionate use programs. 
  
 In any transfers of Licensed Products between Company and an Affiliate or Sublicensee, Net Sales shall be calculated based on the final sale of the
Licensed Product to an independent third party. In the event that Company or an Affiliate or Sublicensee receives non-monetary consideration for any Licensed Products, Net Sales shall be calculated based on the fair market value of such
consideration. . 
  

 2 

 In the case of Combination Products, Net Sales means the gross amount billed or invoiced on sales of the
Combination Product less the deductions set forth above, multiplied by a proration factor that is determined as follows: 
  
 (i) If all components of the Combination Product were sold separately during the same or immediately preceding Royalty Period, the
proration factor shall be determined by the formula [A / (A+B)], where A is the aggregate gross sales price of all Licensed Product components during such period when sold separately from the other essential functional components, and B is the
aggregate gross sales price of the other essential functional components during such period when sold separately from the Licensed Product Components; or 
  
 (ii) If all components of the Combination Product were not sold separately during the same or immediately preceding Royalty Period, the
proration factor shall be determined by the formula [C / (C+D)], where C is the aggregate fully absorbed cost of the Licensed Product components during the prior Royalty Period and D is the aggregate fully absorbed cost of the other essential
functional components during the prior Royalty Period, with such costs being determined in accordance with generally accepted accounting principles. 
  
 1.8. “Patent Rights” means the U.S. patent applications listed on Exhibit A, and any divisional, continuation, or
continuation-in-part of such patent applications to the extent the claims are directed to subject matter specifically described therein, as well as any patent issued thereon and any reissue or reexamination of such patent, and any foreign
counterparts to such patents and patent applications. Exhibit A shall be periodically amended to include any additional Patent Rights that may arise. “Medical School Patent Rights” means Patent Rights assigned to the Medical School
and the joint owners Massachusetts Institute of Technology, the Whitehead Institute for Biomedical Research, and Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. 
  
 1.9. “Royalty Period” means the partial calendar quarter commencing on the date on which the first Licensed
Product is sold or used every complete or partial calendar quarter thereafter during which either (a) this Agreement remains in effect or (b) Company has the right to complete and sell work-in-progress and inventory of Licensed Products pursuant to
Section 6.5. 
  
 1.10. “Sublicensee” means any permitted
sublicensee of the rights granted Company under this Agreement, as further described in Section 2.2. 
  
 1.11. “Sublicense Income” means any payments that Company receives from a Sublicensee in consideration of the sublicense of the rights granted
Company under Section 2.1., including without limitation license fees, royalties, milestone payments, and license maintenance fees, but excluding the following payments: (a) payments made in consideration for the issuance 
  

 3 

 
of equity or debt securities of Company at fair market value, and (b) payments specifically committed to the development of Licensed Products. 
  
 2. Grant of Rights. 
  
 2.1. Subject to the terms of this Agreement, Medical School hereby grants to
Company and its Affiliates a non-exclusive, worldwide, royalty-bearing license (with the right to sublicense) under its commercial rights in the Patent Rights and Biological Materials to develop, make, have made, use, and sell Licensed Products in
the Field. 
  
 2.2. Sublicenses. Company shall have the right to
grant sublicenses of its rights under Section 2.1. with the consent of Medical School, which consent shall not be unreasonably withheld or delayed. All sublicense agreements executed by Company pursuant to this Article 2 shall expressly bind the
Sublicensee to the terms of this. Company shall promptly furnish Medical School with a fully executed copy of any such sublicense agreement. 
  
 3. Company Obligations Relating to Commercialization. 
  
 3.1. Diligence Requirements. Company shall use diligent efforts or shall cause its Affiliates or Sublicensees to use
diligent efforts to develop Licensed Products and to introduce Licensed Products into the commercial market; thereafter, Company or its Affiliates or Sublicensees shall make Licensed Products reasonably available to the public. Specifically, Company
or its Affiliates or Sublicensees shall fulfill the following obligations: 
  
 (a) Within ninety (90) days after the Effective Date, Company shall furnish Medical School with a written research and development plan under which Company intends to develop Licensed Products. 
  
 (b) Within sixty (60) days after each anniversary of the
Effective Date, Company shall furnish Medical School with a written report on the progress of its efforts during the prior year to develop and commercialize Licensed Products, including without limitation research and development efforts, efforts to
obtain regulatory approval, marketing efforts, and sales figures. The report shall also contain a discussion of intended efforts and sales projections for the current year. 
  
 (c) Company shall endeavor to obtain all necessary governmental approvals for the manufacture, use and sale
of Combination Product and Licensed Product. Specifically, Company shall: 
  
 (i) Within eight (8) years after the Effective Date, file an Investigational New Drug Application (“IND”) or its equivalent covering at least one Combination Product or Licensed Product with the U.S. Food
and Drug Administration (“FDA”); 
  

 4 

 (ii) Within thirteen (13) years after the Effective Date, file a New Drug Application
(“NDA”) with the FDA covering at least one Combination Product or Licensed Product; 
  
 (iii) Within eighteen (18) months after receiving FDA approval of the NDA for a Combination Product or Licensed Product, market at least
one Combination Product or Licensed Product in the U.S.; and 
  
 (iv) reasonably fill the market demand for any Combination Product or Licensed Product following commencement of marketing of such product at any time during the exclusive period of this Agreement. 
  
 (d) Within eighteen (18) months after the Effective Date,
Company shall successfully undertake a public or private offering of raising ten million dollars ($10,000,000). 
  
 (e) In addition to the obligations set forth above, Company or its Affiliates or Sublicensees shall spend (either directly or through
sponsored research by Company or its Affiliates or Sublicensees at the Medical School) an aggregate of not less than {***} per calendar year for the development of Combination Product and/or Licensed Product commencing with the year 2004.

  
 Company shall have the responsibility to finance its obligations in this
Section 3.1, and the Medical School shall provide reasonable cooperation to Company in this regard. In the event that Medical School determines that Company (or an Affiliate or Sublicensee) has not fulfilled its obligations under this Section 3.1.,
Medical School shall furnish Company with written notice of such determination. Within sixty (60) days after receipt of such notice, Company shall either (i) fulfill the relevant obligation or (ii) negotiate with Medical School a mutually acceptable
schedule of revised diligence obligations, failing which Medical School shall have the right, immediately upon written notice to Company, to terminate this Agreement. 
  
 3.2. Indemnification. 
  
 (a) Indemnity. Company shall indemnify, defend, and hold harmless Medical School and its trustees, officers, faculty, students, employees, and
agents and their respective successors, heirs and assigns (the “Indemnitees”), against any liability, damage, loss, or expense (including reasonable attorneys fees and expenses of litigation) incurred by or imposed upon any of the
Indemnitees in connection with any claims, suits, actions, demands or judgments arising out of any theory of liability (including without limitation actions in the form of tort, warranty, or strict liability and regardless of whether such action has
any factual basis) concerning any product, process, or service that is made, used, or sold pursuant to any right or license granted under this Agreement; provided, however, that such indemnification shall not apply to any liability, damage, loss, or
expense to the extent directly attributable to (i) the negligent activities 
  
  *** The information marked by asterisks on this page has been omitted pursuant to a request for confidential treatment. The omitted information has been filed separately with the Securities and Exchange Commission. 
   

 5 

 
or intentional misconduct of the Indemnitees or (ii) the settlement of a claim, suit, action, or demand by Indemnitees without the prior written approval of
Company. 
  
 (b) Procedures. The Indemnitees agree to
provide Company with prompt written notice of any claim, suit, action, demand, or judgment for which indemnification is sought under this Agreement. Company agrees, at its own expense, to provide attorneys reasonably acceptable to Medical School to
defend against any such claim. The Indemnitees shall cooperate fully with Company in such defense and will permit Company to conduct and control such defense and the disposition of such claim, suit, or action (including all decisions relative to
litigation, appeal, and settlement); provided, however, that any Indemnitee shall have the right to retain its own counsel, at the expense of Company, if representation of such Indemnitee by the counsel retained by Company would be inappropriate
because of actual or potential differences in the interests of such Indemnitee and any other party represented by such counsel. Company agrees to keep Medical School informed of the progress in the defense and disposition of such claim and to
consult with Medical School with regard to any proposed settlement. 
  
 (c) Insurance. Company shall maintain insurance or self-insurance that is reasonably adequate to fulfill any potential obligation to the Indemnitees, but in any event not less than one million dollars ($1,000,000) for injuries to any
one person arising out of a single occurrence and five million dollars ($5,000,000) for injuries to all persons arising out of a single occurrence. Company shall provide Medical School, upon request, with written evidence of such insurance or
self-insurance. Company shall continue to maintain such insurance or self-insurance after the expiration or termination of this Agreement during any period in which Company or any Affiliate or Sublicensee continues to make, use, or sell a product
that was a Licensed Product under this Agreement and thereafter for a period of two (2) years. 
  
 3.3. Use of Medical School Name. In accordance with Section 6.3., Company and its Affiliates and Sublicensees shall not use the name “University of Massachusetts Medical School” or any variation of
that name in connection with the marketing or sale of any Licensed Products. 
  
 3.4. Marking of Licensed Products. To the extent commercially feasible and consistent with prevailing business practices, Company shall mark, and shall cause its Affiliates and Sublicensees to mark, all
Licensed Products that are manufactured or sold under this Agreement with the number of each issued patent under the Patent Rights that applies to such Licensed Product. 
  
 3.5. Compliance with Law. Company shall comply with, and shall ensure that its Affiliates and Sublicensees comply
with, all local, state, federal, and international laws and regulations relating to the development, manufacture, use, and sale of Licensed Products. Company expressly agrees to comply with the following: 
  
 (a) Company or its Affiliates and Sublicensees shall obtain
all necessary approvals from the United States Food & Drug Administration and any similar 
  

 6 

 
governmental authorities of any foreign jurisdiction in which Company or an Affiliate or Sublicensee intends to make, use, or sell Licensed Products.

  
 (b) Company and its Affiliates and
Sublicensees shall comply with all United States laws and regulations controlling the export of certain commodities and technical data, including without limitation all Export Administration Regulations of the United States Department of Commerce.
Among other things, these laws and regulations prohibit, or require a license for, the export of certain types of commodities and technical data to specified countries. Company hereby gives written assurance that it will comply with, and will cause
its Affiliates and Sublicensees to comply with, all United States export control laws and regulations, that it bears sole responsibility for any violation of such laws and regulations by itself or its Affiliates and Sublicensees, and that it will
indemnify, defend, and hold Medical School harmless (in accordance with Section 3.1.) for the consequences of any such violation. 
  
 4. Consideration for Grant of Rights. 
  
 4.1. License Fee. In partial consideration of the rights granted Company under this Agreement, Company shall pay to Medical School, within thirty
(30) days after the Effective Date, (a) a license fee of {***}, and (b) a payment in the amount of {***} to reimburse Medical School for its actual expenses incurred as of January 31, 2003 in connection with obtaining the Patent Rights. These
license fee payments are nonrefundable and are not creditable against any other payments due to Medical School under this Agreement. 
  
 4.2. Equity. In partial consideration of the license granted to Company under this Agreement, on or about April 18, 2003, Company shall issue to Medical
School a total number of shares of Common Stock of Company, ($.01 par value per share) equal to {***} of the outstanding shares of Company. Company shall register the shares that are issued to the Medical School within ninety (90) days after their
issuance and those shares will then be unrestricted. 
  
 4.3.
License Maintenance Fee. Beginning on the anniversary of the Effective Date, and in each calendar year during the term of the Agreement, Company shall pay to Medical School {***}. This annual license maintenance fee is nonrefundable and is
not creditable against any other payments due to Medical School under this Agreement. 
  
 4.4. Royalties. In partial consideration of the rights granted Company under this Agreement, Company shall pay to Medical School a royalty of {***} of Net Sales of Licensed Products by Company and its
Affiliates. 
  
 (a) If there is a competing product in the
marketplace, no royalties are due for a Licensed Product that is within the definition of “Licensed Product” because it uses or incorporates only Biological Materials. 
  
  *** The information marked by asterisks on this page has been omitted pursuant to a request for confidential treatment. The omitted
information has been filed separately with the Securities and Exchange Commission. 
   

 7 

 (b) If during the Royalty Period, patents under the Patent Rights have expired or have been abandoned in
a particular country, (i) no royalty is payable by Company, if there is a competing product in that country, and (ii) if Company reduces its prices for Licensed Products in that country, even if there is no competing product in that country, Company
and Medical School shall negotiate in good faith a reduction in the royalty rate to reflect the reduction in Company’s gross margins caused by the price reduction. 
  
 (c) Company shall pay Medical School {***} of Net Sales of commercial clinical laboratory services by Company and its
Affiliates. 
  
 4.5. Minimum Royalty. At the beginning of
each calendar year during the term of this Agreement, beginning January 1, 2016, Company shall pay to Medical School a minimum royalty of {***}. If the actual royalty payments to Medical School in any calendar year are less than the minimum royalty
payment required for that year, Company shall have the right to pay Medical School the difference between the actual royalty payment and the minimum royalty payment in full satisfaction of its obligations under this Section, provided such minimum
payment is made to Medical School within sixty (60) days after the conclusion of the calendar year. Waiver of any minimum royalty payment by Medical School shall not be construed as a waiver of any subsequent minimum royalty payment. If Company
fails to make any minimum royalty payment within the sixty-day period, such failure shall constitute a material breach of its obligations under this Agreement, and Medical School shall have the right to terminate this Agreement in accordance with
Section 7.3. 
  
 4.6. Third-Party Royalties. If Company is legally
required to make royalty payments to Medical School under any agreement other than this Agreement (the “Other Medical School Licenses”), or to one or more third parties in the same Royalty Period for which royalties are due under Section
4.5 or 4.7 in order for Company to make, use or sell Licensed Products or have its sublicense make, use, or sell Licensed Products: 
  

	 	(a)	 	in the case of any payments to Medical School under Other Medical School Licenses with respect to Licensed Products under this Agreement, the royalty payment made by Company to
Medical School under this Agreement for the applicable Royalty Payment shall be reduced by fifty percent (50%) of the aggregate amounts payable for the same Royalty Period under the Other Medical School Licenses (before making any similar reduction
in those payments pursuant to a corresponding reduction clause in those agreements), with a minimum floor of {***} of Net Sales of Licensed Products or {***} of the Sublicense Income to be paid under this Agreement; and 

  

	 	(b)	 	in the case of payments to one or more third parties, an offset of fifty percent (50%) of the amount paid to third parties may be taken by Company against any royalties payable by
Company to the Medical School under this Agreement with a minimum floor of {***} of Net Sales of Licensed Products or {***} of all Sublicense Income, 

  
  *** The information marked by asterisks on this page has been omitted pursuant to a request for confidential treatment. The omitted
information has been filed separately with the Securities and Exchange Commission. 
   

 8 

	 	 
provided that in no event shall the royalty payments under Section 4.5 and 4.7, when aggregated with any other offsets and credits allowed under this
Agreement, be reduced by more than fifty percent (50%); in the case of payments to one or more third parties, Medical School shall receive {***} of the Sublicense Income net of the foregoing third party payments; and 

  

	 	(c)	 	in the case of both payments under Other Medical School Licenses and to third parties in the same Royalty Period, the reduction described in (i) above shall first be made, and then
the offset described in (ii) above shall be taken, provided that only a pro rata amount of the offset pursuant to (ii) above shall be taken against the royalties payable under this Agreement (with the pro-ration calculated based on the relative
royalty rates under this Agreement and the Other Medical School Licenses), with a minimum floor under this Agreement of {***} of Net Sales of Licensed Products and {***} of Sublicense Income. 

  
 By way of illustration, assume a royalty of {***} under the Other Medical
School Licenses of Net Sales of Licensed Products and a payment of {***} of Net Sales of Licensed Products to a third party. The reduction and offsets calculation would be as follows: 
  

	 	(i)	 	The {***} of Net Sales of Licensed Products would be reduced to {***} of Net Sales of Licensed Products (i.e., a reduction of 50% of the {***} of Net Sales of Licensed Products
under Other Medical School Licenses); and 

  
 (ii)
The remaining {***} of Net Sales of Licensed Products would be offset by an amount equal to {***} of Net Sales of Licensed Products, for a net royalty to the Medical School under this Agreement of {***} of Net Sales of Licensed Products (i.e., the
offset of 50% of the {***} of Net Sales of Licensed Products payable to the third party is allocated pro rata against Medical School under this Agreement, with 33 1/3% of this net offset of {***} of Net Sales of Licensed Products being allocated to the royalties under this Agreement (the {***} royalty rate under this Agreement divided by the
{***} royalty rate under this Agreement plus the {***} royalty rate under the Other Medical School Licenses)). 
  
 5. Royalty Reports; Payments; Records. 
  
 5.1. First Sale. Company shall report to Medical School the date of first commercial sale of each Licensed Product within thirty (30) days of
occurrence in each country. 
  
 5.2. Reports and Payments.
Within sixty (60) days after the conclusion of each Royalty Period, Company shall deliver to Medical School a report containing the following information: 
  

*** The information marked by asterisks on this page has been omitted pursuant to a request for confidential treatment. The omitted information has been filed
separately with the Securities and Exchange Commission. 
   

 9 

 (a) the number of Licensed Products sold to independent third parties in each country,
and the number of Licensed Products used by Company and its Affiliates in the provision services in each country; 
  
 (b) the gross sales price for each Licensed Product by Company and its Affiliates or Sublicensees during the applicable Royalty Period in
each country; 
  
 (c) calculation of Net Sales for
the applicable Royalty Period in each country, including a listing of applicable deductions; and 
  
 (d) total royalty payable on Net Sales in U.S. dollars, together with the exchange rates used for conversion. 
  
 If no royalties are due to Medical School for any Royalty Period, the report shall so state.
Concurrent with this report, Company shall remit to Medical School any payment due for the applicable Royalty Period. Medical School shall instruct Company as to the method of payment. The contents of all such reports shall be the confidential and
proprietary information of Company. To the extent permitted by applicable law, Medical School shall use reasonable efforts to maintain the confidentiality of such reports. 
  
 5.3. Payments in U.S. Dollars. All payments due under this Agreement shall be payable in United States dollars.
Conversion of foreign currency to U.S. dollars shall be made at the conversion rate existing in the United States (as reported in the Wall Street Journal) on the last working day of the calendar quarter preceding the applicable Royalty
Period. Such payments shall be without deduction of exchange, collection, or other charges. 
  
 5.4. Payments in Other Currencies. If by law, regulation, or fiscal policy of a particular country, conversion into United States dollars or transfer of funds of a convertible currency to the United States is
restricted or forbidden, Company shall give Medical School prompt written notice of such restriction, which notice shall satisfy the sixty-day payment deadline described in Section 5.2. Company shall pay any amounts due Medical School through
whatever lawful methods Medical School reasonably designates; provided, however, that if Medical School fails to designate such payment method within thirty (30) days after Medical School is notified of the restriction, Company may deposit such
payment in local currency to the credit of Medical School in a recognized banking institution selected by Company and identified by written notice to Medical School, and such deposit shall fulfill all obligations of Company to Medical School with
respect to such payment. 
  
 5.5. Records. Company shall
maintain, and shall cause its Affiliates to maintain, complete and accurate records of Licensed Products that are made, used, sold, or performed under this Agreement and any amounts payable to Medical School in relation to such Licensed Products,
which records shall contain sufficient information to permit Medical School to confirm the accuracy of any reports delivered to Medical School under Section 5.2. The relevant party shall 
  

 10 

 
retain such records relating to a given Royalty Period for at least three (3) years after the conclusion of that Royalty Period, during which time Medical
School shall have the right, at its expense, to cause its internal accountants or an independent, certified public accountant to inspect such records during normal business hours for the sole purpose of verifying any reports and payments delivered
under this Agreement. Such accountant shall not disclose to Medical School any information other than information relating to accuracy of reports and payments delivered under this Agreement. The parties shall reconcile any underpayment or
overpayment within thirty (30) days after the accountant delivers the results of the audit. In the event that any audit performed under this Section reveals an underpayment in excess of the greater of (a) five thousand dollars ($5,000) or (b) ten
percent (10%) in any Royalty Period, Company shall bear the full cost of such audit. Medical School may exercise its rights under this Section only once every year and only with reasonable prior notice to Company. 
  
 5.6. Late Payments. Any payments by Company that are not paid on or
before the date such payments are due under this Agreement shall bear interest, to the extent permitted by law, at two percentage points above the Prime Rate of interest as reported in the Wall Street Journal on the date payment is due, with
interest calculated based on the number of days that payment is delinquent. 
  
 5.7. Method of Payment. All payments under this Agreement should be made in the name of the “Medical School of Massachusetts” and sent to the address identified below. Each payment should reference
this Agreement and identify the obligation under this Agreement that the payment satisfies. 
  
 5.8. Withholding and Similar Taxes. Royalty payments and other payments due to Medical School under this Agreement shall be reduced by reason of any withholding or similar taxes applicable to such payments to
Medical School, which shall be paid by Company as required by applicable law and reported by Company to the Medical School. 
  
 6. Confidential Information; Publications; Publicity. 
  
 6.1. Confidential Information. 
  
 (a) Designation. Confidential Information that is disclosed in writing shall be marked with a legend indicating its
confidential status (such as “Confidential” or “Proprietary”). Confidential Information that is disclosed orally or visually shall be documented in a written notice prepared by the Disclosing Party and delivered to the Receiving
Party within thirty (30) days of the date of disclosure; such notice shall summarize the Confidential Information disclosed to the Receiving Party and reference the time and place of disclosure. 
  
 (b) Obligations. For a period of five (5) years after disclosure of
any portion of Confidential Information, the Receiving Party shall (i) maintain such Confidential Information in strict confidence, except that the Receiving Party may disclose or permit the disclosure of any 
  

 11 

 
Confidential Information to its directors, officers, employees, consultants, and advisors who are obligated to maintain the confidential nature of such
Confidential Information and who need to know such Confidential Information for the purposes of this Agreement; (ii) use such Confidential Information solely for the purposes of this Agreement; and (iii) allow its trustees or directors, officers,
employees, consultants, and advisors to reproduce the Confidential Information only to the extent necessary for the purposes of this Agreement, with all such reproductions being considered Confidential Information. 
  
 (c) Exceptions. The obligations of the Receiving Party under
Subsection 6.1.(b) above shall not apply to the extent that the Receiving Party can demonstrate that certain Confidential Information (i) was in the public domain prior to the time of its disclosure under this Agreement; (ii) entered the public
domain after the time of its disclosure under this Agreement through means other than an unauthorized disclosure resulting from an act or omission by the Receiving Party; (iii) was independently developed or discovered by the Receiving Party without
use of the Confidential Information; (iv) is or was disclosed to the Receiving Party at any time, whether prior to or after the time of its disclosure under this Agreement, by a third party having no fiduciary relationship with the Disclosing Party
and having no obligation of confidentiality with respect to such Confidential Information; or (v) is required to be disclosed to comply with applicable laws or regulations, or with a court or administrative order, provided that the Disclosing Party
receives reasonable prior written notice of such disclosure. 
  
 (d) Ownership and Return. The Receiving Party acknowledges that the Disclosing Party (or any third party entrusting its own information to the Disclosing Party) claims ownership of its Confidential Information in the possession of
the Receiving Party. Upon the expiration or termination of this Agreement, and at the request of the Disclosing Party, the Receiving Party shall return to the Disclosing Party all originals, copies, and summaries of documents, materials, and other
tangible manifestations of Confidential Information in the possession or control of the Receiving Party, except that the Receiving Party may retain one copy of the Confidential Information in the possession of its legal counsel solely for the
purpose of monitoring its obligations under this Agreement. 
  
 6.2. Publications. Medical School and its employees will be free to publicly disclose (through journals, lectures, or otherwise) the results of any research in the Field or relating to the subject matter of the Patent Rights, except
as otherwise provided by written agreement between Medical School and Company (e.g., a sponsored research agreement). 
  
 6.3. Publicity Restrictions. Company shall not use the name of Medical School or any of its trustees, officers, faculty, students, employees, or
agents, or any adaptation of such names, or any terms of this Agreement in any promotional material or other public announcement or disclosure without the prior written consent of Medical School. The foregoing notwithstanding, Company shall have the
right to disclose such information without the consent of Medical School in any prospectus, offering memorandum, or other document or filing required by 
  

 12 

 
applicable securities laws or other applicable law or regulation, provided that Company shall have given Medical School at least ten (10) days (or such prior
shorter period in order to enable Company to make a timely announcement, while affording the Medical School the maximum feasible time to review the announcement) prior written notice of the proposed text for the purpose of giving Medical School the
opportunity to comment on such text. 
  
 7.
Term and Termination. 
  
 7.1. Term. This Agreement
shall commence on the Effective Date and shall remain in effect until (a) the expiration of all issued patents within the Patent Rights or (b) for a period of ten (10) years after the Effective Date if no such patents have issued within that
ten-year period, unless earlier terminated in accordance with the provisions of this Agreement. 
  
 7.2. Termination for Default. In the event that either party commits a material breach of its obligations under this Agreement and fails to cure
that breach within sixty (60) days after receiving written notice thereof, the other party may terminate this Agreement immediately upon written notice to the party in breach. 
  
 7.4. Force Majeure. Neither party will be responsible for delays resulting from causes beyond the reasonable control
of such party, including without limitation fire, explosion, flood, war, strike, or riot, provided that the nonperforming party uses commercially reasonable efforts to avoid or remove such causes of nonperformance and continues performance under
this Agreement with reasonable dispatch whenever such causes are removed. 
  
 7.5. Effect of Termination. The following provisions shall survive the expiration or termination of this Agreement: Articles 1 and 8; Sections 3.2., 3.5., 5.2. (obligation to provide final report and payment),
6.1., 7.5., and 9.9. Upon the early termination of this Agreement, Company and its Affiliates or Sublicensees may complete and sell any work-in-progress and inventory of Licensed Products that exist as of the effective date of termination, provided
that (a) Company is current in payment of all amounts due Medical School under this Agreement, (b) Company pays Medical School the applicable royalty on such sales of Licensed Products in accordance with the terms and conditions of this Agreement,
and (c) Company and its Affiliates or Sublicensees shall complete and sell all work-in-progress and inventory of Licensed Products within six (6) months after the effective date of termination. 
  
 8. Dispute Resolution. 
  
 8.1. Procedures Mandatory. The parties agree that any dispute arising
out of or relating to this Agreement shall be resolved solely by means of the procedures set forth in this Article, and that such procedures constitute legally binding obligations that are an essential provision of this Agreement; provided, however,
that all procedures and deadlines specified in this Article may be modified by written agreement of the parties. If either party fails to observe the procedures of 
  

 13 

 
this Article, as modified by their written agreement, the other party may bring an action for specific performance in any court of competent jurisdiction.

  
 8.2. Dispute Resolution Procedures. 
  
 (a) Negotiation. In the event of any dispute arising out of or
relating to this Agreement, the affected party shall notify the other party, and the parties shall attempt in good faith to resolve the matter within ten (10) days after the date of such notice (the “Notice Date”). Any disputes not
resolved by good faith discussions shall be referred to senior executives of each party, who shall meet at a mutually acceptable time and location within thirty (30) days after the Notice Date and attempt to negotiate a settlement. 
  
 (b) Mediation. If the matter remains unresolved within sixty (60) days
after the Notice Date, or if the senior executives fail to meet within thirty (30) days after the Notice Date, either party may initiate mediation upon written notice to the other party, whereupon both parties shall be obligated to engage in a
mediation proceeding under the then current Center for Public Resources (“CPR”) Model Procedure for Mediation of Business Disputes, except that specific provisions of this Section shall override inconsistent provisions of the CPR Model
Procedure. The mediator will be selected from the CPR Panels of Neutrals. If the parties cannot agree upon the selection of a mediator within ninety (90) days after the Notice Date, then upon the request of either party, the CPR shall appoint the
mediator. The parties shall attempt to resolve the dispute through mediation until one of the following occurs: (i) the parties reach a written settlement; (ii) the mediator notifies the parties in writing that they have reached an impasse; (iii)
the parties agree in writing that they have reached an impasse; or (iv) the parties have not reached a settlement within one hundred and twenty (120) days after the Notice Date. 
  
 (c) Trial Without Jury. If the parties fail to resolve the dispute through mediation, or if neither party elects to
initiate mediation, each party shall have the right to pursue any other remedies legally available to resolve the dispute, provided, however, that the parties expressly waive any right to a jury trial in any legal proceeding under this Section.

  
 8.3. Preservation of Rights Pending Resolution.

  
 (a) Performance to Continue. Each party shall continue
to perform its obligations under this Agreement pending final resolution of any dispute arising out or relating to this Agreement; provided, however, that a party may suspend performance of its obligations during any period in which the other party
fails or refuses to perform its obligations. 
  
 (b)
Provisional Remedies. Although the procedures specified in this Article are the sole and exclusive procedures for the resolution of disputes arising out of relating to this Agreement, either party may seek a preliminary injunction or other
provisional equitable relief if, in its reasonable judgment, such action is necessary to avoid irreparable harm to itself or to preserve its rights under this Agreement. 
  

 14 

 (c) Statute of Limitations. The parties agree that all applicable statutes of limitation and
time-based defenses (such as estoppel and laches) shall be tolled while the procedures set forth in Subsections 8.2.(a) and 8.2(b) are pending. The parties shall take any actions necessary to effectuate this result. 
  
 9. Miscellaneous. 
  
 9.1. Representations and Warranties. Representations and Warranties.
Medical School represents and warrants that its employees have assigned to Medical School their entire right, title, and interest in the Patent Rights, that it has authority to grant the rights and licenses set forth in this Agreement, and that, to
its best knowledge, Medical School does not hold any other intellectual property rights that would be infringed by the exploitation of the Patent Rights. MEDICAL SCHOOL MAKES NO OTHER WARRANTIES CONCERNING THE PATENT RIGHTS AND BIOLOGICAL MATERIALS,
INCLUDING WITHOUT LIMITATION ANY EXPRESS OR IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Specifically, Medical School makes no warranty or representation (a) that the exploitation of any Licensed Product will not infringe
any patents or other intellectual property rights of a third party, (b) regarding the validity or scope of the Patent Rights, and (c) that any third party is not currently infringing or will not infringe the Patent Rights. 
  
 9.2. Compliance with Law and Policies. Company agrees to comply with
applicable law and the policies of Medical School in the area of technology transfer and shall promptly notify Medical School of any violation that Company knows or has reason to believe has occurred or is likely to occur. The Medical School
policies currently in effect at 365 Plantation Street, Ste. 130, Worcester MA, 01605 campus are available online at www.umassmed.edu/research/policies. 
  
 9.3. Tax-Exempt Status. Company acknowledges that Medical School, as a public institution of the Commonwealth of Massachusetts, holds the status of
an exempt organization under the United States Internal Revenue Code. Company also acknowledges that certain facilities in which the licensed inventions were developed may have been financed through offerings of tax-exempt bonds. If the Internal
Revenue Service determines, or if counsel to Medical School reasonably determines, that any term of this Agreement jeopardizes the tax-exempt status of Medical School or the bonds used to finance Medical School facilities, the relevant term shall be
deemed an invalid provision and modified in accordance with Section 10.11. 
  
 9.4. Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, and all of which together shall be deemed to be one and the same instrument. 

 

 15 

 9.5. Headings. All headings are for convenience only and shall not affect the meaning of any
provision of this Agreement. 
  
 9.6. Binding Effect. This
Agreement shall be binding upon and inure to the benefit of the parties and their respective permitted successors and assigns. 
  
 9.7. Assignment. This Agreement may not be assigned by either party without the prior written consent of the other party, except that Company may
assign this Agreement to an Affiliate or to a successor in connection with the merger, consolidation, or sale of all or substantially all of its assets or that portion of its business to which this Agreement relates. 
  
 9.8. Amendment and Waiver. This Agreement may be amended,
supplemented, or otherwise modified only by means of a written instrument signed by both parties. Any waiver of any rights or failure to act in a specific instance shall relate only to such instance and shall not be construed as an agreement to
waive any rights or fail to act in any other instance, whether or not similar. 
  
 9.9. Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts irrespective of any conflicts of law principles. 
  
 9.10. Notice. Any notices required or permitted under this Agreement
shall be in writing, shall specifically refer to this Agreement, and shall be sent by hand, recognized national overnight courier, confirmed facsimile transmission, confirmed electronic mail, or registered or certified mail, postage prepaid, return
receipt requested, to the following addresses or facsimile numbers of the parties: 
  
 If to Medical School: 
  
 Office
of Technology Management 
 Medical School of Massachusetts 
 365 Plantation Street, Suite 130 
 Worcester, MA 01605 
 Attention:      Joseph F.X. McGuirl 
                         Executive Director 
  
 Tel: (508) 856-1626 
 Fax: (508) 856-1482 
  

 16 

 If to Company: 
  

CytRx Corporation 
 11726 San Vicente
Blvd., Suite 650 
 Los Angeles, CA 90049 
 Attention:      Steven A. Kriegsman 
                         Chief Executive Officer 
  
 Tel: (310) 826-5449 
 Fax: (310) 826-5529 
  
 All notices under this Agreement shall be deemed
effective upon receipt. A party may change its contact information immediately upon written notice to the other party in the manner provided in this Section. 
  
 9.11. Severability. In the event that any provision of this Agreement shall be held invalid or unenforceable for any reason, such invalidity or
unenforceability shall not affect any other provision of this Agreement, and the parties shall negotiate in good faith to modify the Agreement to preserve (to the extent possible) their original intent. If the parties fail to reach a modified
agreement within sixty (60) days after the relevant provision is held invalid or unenforceable, then the dispute shall be resolved in accordance with the procedures set forth in Article 7. While the dispute is pending resolution, this Agreement
shall be construed as if such provision were deleted by agreement of the parties. 
  
 9.12. Entire Agreement. This Agreement constitutes the entire agreement between the parties with respect to its subject matter and supersedes all prior agreements or understandings between the parties relating
to its subject matter. 
  
 IN WITNESS WHEREOF, the parties have
caused this Agreement to be executed by their duly authorized representatives as of the date first written above. 
  

	 MEDICAL SCHOOL OF MASSACHUSETTS
	 	 CYTRX CORPORATION

				
	 By:
	 	 /s/ Joseph F.X. McGuirl

	 	 By:
	 	 /s/ Steven A. Kriegsman

	 	 	 Joseph F.X. McGuirl
	 	 Steven A. Kriegsman

	 	 	 Executive Director, CVIP
	 	 Chief Executive Officer

  
  

 17 

 EXHIBIT A 
  
 List of Patent Rights 
  
 UMMC 01-36 “RNA Sequence-Specific Mediators of RNA Interference” 
 Inventors: David P. Bartel, Philip A. Sharp, Thomas Tuschl, and Philip D. Zamore 
  

	 	I.	 	United States Patents and Application 

  
 USSN 60/265232 entitled “RNA Sequence-Specific Mediators of RNA Interference”, by 
 David P. Bartel, Philip A. Sharp, Thomas Tuschl, and Philip D. Zamore 
  
 USSN 09/821832 entitled “RNA Sequence-Specific Mediators of RNA Interference”, by 
 David P. Bartel, Philip A. Sharp, Thomas Tuschl, and Philip D. Zamore 
  

	 	II.	 	International (non-U.S.) Patents and Applications 

  
 PCT/US01/10188 entitle “RNA Sequence-Specific Mediators of RNA Interference”, by 
 David P. Bartel, Philip A. Sharp, Thomas Tuschl, and Philip D. Zamore

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