Document:

Common Stock Certificate

EXHIBIT
4.1

BOV1E
MEDICAL CORPORATION

COMMON
STOCK

INCORPORATED
UNDER THE LAWS OF THE STATE OF DELAWARE

This

Certifies

that

is the

owner
of

FULLY
PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK OF THE PAR VALUE OF $.001 PER
SHARE OF

 

BOVIE
MEDICAL CORPORATION

 

(hereinafter
called the ‘Corporation’') transferable on the books of the Corporation in
person or by duly authorized attorney upon surrender of this Certificate
Properly endorsed. This Certificate and the shared represented hereby Are issued
end shall be held subject to all the provision of the Certificate of
Incorporation and By-Laws of the Corporation and the amendments from time to
time made thereto, copies of' which are or will
be on file at the principal office of the Corporation, to all of which the
holder by acceptance hereof assents.

This
Certificate is not valid unless countersigned by The Transfer Agent and
Registrar.

WITNESS
the facsimile seal of the Corporation and the facsimile signature of its duly
authorized officers.

Dated:

	
      Countersigned
      and Registered:
	 
	 	
      PRESIDENT

	
      MANHATTAN
      TRANSFER REGISTRAR CO.
	 
	
      (HOLBROOK,
      N.Y.)
	 
	 	
      CHAIRMAN

	
      Transfer
      Agent 
	 
	
      and
      Registrar
	 
	
      Authorized
      SignatureCONFIDENTIAL TREATMENT REQUESTED. CONFIDENTIAL PORTIONS OF THIS DOCUMENT
     HAVE BEEN REDACTED AND HAVE BEEN SEPARATELY FILED WITH THE COMMISSION.

                             CONFIDENTIAL TREATMENT

<PAGE>

                       MANUFACTURING AND SUPPLY AGREEMENT

This  Manufacturing and Supply Agreement is entered into effective as of Tuesday
March 6th, 2003, by and between INyX Pharma Ltd., a company  organized under the
laws of England and Wales ("INyX"),  and Stiefel Laboratories,  Inc., a New York
corporation (the "Customer").

                                   BACKGROUND

A. The Customer  desires to use INyX's  facilities,  resources  and expertise to
manufacture  the  Products,  as  defined  below,  and INyX  desires  to act as a
contract  manufacturer of the Product(s) agreed to by both Parties in accordance
with the terms and conditions set forth in this Agreement;

B. INyX and the  Customer  wish to enter  into  this  manufacturing  and  supply
agreement  on the terms and  conditions  set  forth in this  Agreement,  for the
consideration set forth in this Agreement.

 NOW, THEREFORE, in consideration of the above premises and the mutual covenants
set forth below, INyX and the Customer agree as follows:

                                    AGREEMENT

                                    ARTICLE 1
                                   DEFINITIONS
                                   -----------

For the purposes of this Agreement,  the following  capitalized terms shall have
the following meanings:

"Affiliate"  means any  corporation  or other  business  entity  controlled  by,
controlling  or under  common  control  with a Party  hereto.  For this  purpose
"control"  shall mean direct or indirect  beneficial  ownership of fifty percent
(50%) or more of the voting stock,  or a fifty percent (50%) or more interest in
the income of, such corporation or other business entity.

"Batch" shall have the meaning set forth in the Quality Agreement.

"Certificate  of Analysis" means a summary of the quality  control  testing,  as
described in the Product Specifications,  performed by INyX for Finished Product
supplied under this Agreement.

"Change" shall have the meaning set forth in the Quality Agreement.

"Commercially Reasonable Efforts" means, with respect to a Party, the efforts of
such Party that are reasonable in light of the size of the present and potential
markets for the Products (as reasonably determined by such Party) and consistent
with such Party's efforts used in similar activities regarding other products of
similar market potential.

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<PAGE>

"Confidential  Information"  shall have the  meaning set forth in Section 7.3 of
this Agreement.

"Customer  Representative" means the person designated by the Customer who shall
be  primarily  resident  on  site at  INyX's  facility.  As of the  date of this
Agreement, * * * is designated as the Customer Representative.

"Date of Manufacture" shall have the meaning set forth in the Quality Agreement.

"Dermatological Products" shall have the meaning set forth in Section 4.3.

"Development Agreement" means any separate agreement entered into by the Parties
with respect to a potential  Product that is not yet ready to be manufactured on
a commercial scale,  including the requirements  surrounding production of units
of Product and Placebo  appropriately labeled for use in the Customer's clinical
trials (in amounts to be  specified by the  Customer,  as  required).  Each such
Development  Agreement shall, when executed, be appended to this Agreement as an
Exhibit E.

"DMF" means the Drug Master File for a Product, as filed by INyX with the FDA.

"FDA" means the Food and Drug Administration of the United States of America.

"Finished Product" shall have the meaning set forth in the Quality Agreement.

"IND" means an Investigational  New Drug Application for a Product,  as filed by
the Customer with the FDA.

"INyX" means INyX Pharma Ltd.

"Initial Term" shall have the meaning set forth in Section 10.1.

"Labeling"  means the primary  container  label,  secondary  packaging,  package
insert, shelf pack and shipper label specific to a finished Product manufactured
in accordance with cGMPs and the Customer's instructions.

"Losses" shall have the meaning set forth in Section 11.1.

"Manufacturing Standards" means the specifications for manufacturing, packaging,
labeling and storing the Products set forth in the Product  Specifications,  the
master batch  record,  cGMPs,  MSDSs,  and all other  applicable  U.S.  laws and
regulations.

"MSDS" means material safety data sheets.

"NDA" means a New Drug Application for a Product, as filed by the Customer with,
and approved by the FDA.

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<PAGE>

"Party"  means  INyX or the  Customer  and  "Parties"  means  both  INyX and the
Customer, as the context requires.

"Placebo"  means  a  Product  adjusted  to  be  formulated  without  the  active
ingredient.

"Product  Specifications"  means the specifications  provided by the Customer in
writing for the  manufacture  of any  Product and  accepted by INyX from time to
time,  and  includes  all such  specifications  as may be  required  pursuant to
applicable regulatory laws.

"Product(s)" means Dermatological Products and the products described on Exhibit
A to this Agreement for commercial sale, as it may be properly amended from time
to time by agreement of the Parties, and which is incorporated by this reference
as though fully set forth in this paragraph.

"Quality Agreement" means the Agreement set forth as Exhibit C to this Agreement
and incorporated by this reference as though fully set forth in this Agreement.

"Regulatory   Authority"   means  the  FDA  or  any   equivalent  or  additional
governmental or regulatory  agencies having  jurisdiction  with respect to INyX,
INyX's facilities, or the Products.

"Stiefel" means Stiefel Laboratories, Inc.

"Unique  Materials"  shall have the  meaning  set forth in Section  3.12 of this
Agreement.

                                   ARTICLE 2
                     PRODUCT SPECIFICATIONS AND MANUFACTURE
                     --------------------------------------

2.1   Manufacture of Products
      -----------------------

During the term of this  Agreement,  and subject to the terms and  conditions of
this  Agreement,  INyX  shall  formulate,  fill  and  package  the  Products  in
accordance with their respective Product Specifications,  according to the terms
of this Agreement and the Quality Agreement, as they may be amended from time to
time.

2.2   Conformance to Product Specifications
      -------------------------------------

Products (and jointly  approved for the purposes of this  section,  the Placebo)
shall conform to the Product Specifications, the terms of the Quality Agreement,
and all  specifications  provided in the Customer's IND or NDA.  Notwithstanding
the foregoing, if the Customer accepts Product in accordance with the provisions
of this Agreement and the Quality Agreement, this Section 2.2 shall be deemed to
have been satisfied.

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<PAGE>

2.3   Labeling
      --------

INyX will  label and  package  Product  in  finished  form,  pursuant  to a firm
purchase order accepted by INyX as described in Section 3.4, provided,  however,
that the Customer shall be responsible  for the origination of artwork and text,
as well as final approval before manufacture, of the Labeling.

2.4   Raw Materials
      -------------

INyX shall source all raw materials used in manufacture of the Products  firstly
from sources  designated by the Customer.  The Customer  shall  purchase the raw
materials  and  deliver  same to INyX.  INyX and the  Customer  agree to jointly
develop a procedure for testing raw materials  that meets all FDA  requirements,
prior to the Customer's issuance of its first order for Products hereunder.

2.5   Batch Testing; Certificate of Authenticity
      ------------------------------------------

INyX  shall  test,  or cause  to be  tested,  in  accordance  with  the  Product
Specifications,  each batch of Product  manufactured  pursuant to this Agreement
before delivery to the Customer.  Prior to each shipment of Product,  INyX shall
provide to the Customer a  Certificate  of Analysis  attesting to the quality of
each batch contained  within the shipment,  including review and approval by the
appropriate  quality control unit of all batch  production and control  records.
INyX shall maintain and provide the Customer with such  documentation  as may be
required for compliance with FDA and other applicable regulators.

2.6   Good Manufacturing Practice
      ---------------------------

INyX  shall  manufacture,  store  and  prepare  all  Products  for  shipping  in
accordance with the current Good Manufacturing  Practices  ("cGMPs") of the FDA,
and  the  equivalent  manufacturing  requirements  of  the  European  Regulatory
Authorities,  in an FDA  inspected  and ISO9000  certified  facility,  currently
envisioned  to  be  INyX's  facility  in  Runcorn,  U.K.  INyX  may  not  change
manufacturing  of Products to an alternate  facility without first obtaining the
Customer's  written approval,  including the approvals  required pursuant to the
Quality Agreement, such approvals not to be unreasonably withheld.

2.7   DMF
      ---

To the extent  required,  INyX shall  maintain a DMF,  like  filing or  relevant
registration certificate,  suitable for INyX's manufacture of Products, with the
applicable regulatory agencies (including FDA) and shall ensure that its "active
status" is maintained.  INyX shall use Commercially Reasonable Efforts to timely
accomplish, and bear the costs of, preparing for regulatory inspection, approval
and associated  filings  required for the manufacture of Products.  The Customer
shall  directly  pay or  reimburse  INyX  for  any  fees  and  payments  to such
regulatory  agencies  required  for such  inspection,  approval  and  associated
filings (e.g.,  any FDA inspection  fee); it is understood  that the Customer is
not responsible for fees and payments related to the general operation of INyX's
business or facilities.  INyX will provide  letter(s)  granting the Customer and
its designees the right of  cross-reference  to the DMF. INyX reserves the right
to cancel such  letter(s) in case of  termination  of this  Agreement;  provided
that, any such letter(s) are first offered to be transferred to the Customer and
the Customer declines the transfer.

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<PAGE>

2.8   Inspections
      -----------

The Customer has the right at any time during the term of this  Agreement,  upon
reasonable  prior  notice  and  during  reasonable  business  hours and  without
disruption to INyX's business, to inspect INyX's facility,  and to make FDA-type
inspections at its plant to satisfy itself that INyX  manufactures and documents
the Product  according  to current  cGMPs,  consistent  with FDA  standards  and
requirements.  Such  inspections  may  only be made  by  individuals  reasonably
acceptable  to INyX.  The  provisions  of this  Section  2.8 are  subject to the
confidentiality  provisions of Article 7. The Customer shall be responsible  for
its costs of travel and accommodation for such inspections.

2.9   Changes to Product Specifications
      ---------------------------------

      (a)   If  the  Customer   desires  any  material  change  to  the  Product
            Specifications or manufacturing process, the Customer shall deliver,
            one-hundred  and twenty  (120) days  prior to the  expected  date of
            implementation,  written  notice  to  INyX  specifying  such  change
            desired by the  Customer,  and INyX shall respond to any such notice
            within  thirty (30) days after  INyX's  receipt  thereof;  provided,
            however,  that the Product  Specifications  or process  shall not be
            supplemented,  modified or amended in any respect  without the prior
            written  agreement  of  the  Parties.  INyX  will  use  Commercially
            Reasonable  Efforts to  implement  changes  within  one-hundred  and
            twenty (120) days.  If the  Customer  requests a change to a Product
            Specification,  including the manufacturing process, and INyX agrees
            that such  change is  feasible,  such change  shall be  incorporated
            within the Product Specification  pursuant to a written amendment to
            this Agreement.  The Customer shall be responsible for obtaining any
            required FDA approval  prior to  implementation  of such a change at
            the Customer's cost.

      (b)   INyX will  communicate to the Customer in a timely manner any change
            in the Product  Specification,  including the manufacturing process,
            initiated by INyX, and will obtain the Customer's  written  approval
            by way of written  amendment of this  Agreement  incorporating  such
            change within the Product  Specification  prior to implementation of
            the change.  No such change may be  instituted  except in compliance
            with this  Agreement and the Quality  Agreement.  The Customer shall
            have the option of obtaining, or having INyX obtain any required FDA
            approval prior to implementation of such a change.  INyX may provide
            additional services in conjunction with the manufacture of Products,
            such as additional formulation,

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<PAGE>

            process  development  or  stability  testing,  at the request of the
            Customer and pursuant to the Customer's purchase order, and all data
            and  results  from such  additional  services  shall be owned by the
            Customer and protected as confidential under this Agreement.

2.10  Customer Representative at INyX
      -------------------------------

The Customer  may, at the  Customer's  expense,  place a company  representative
on-site at INyX's  manufacturing  facility  during  the term of this  Agreement.
Subject to the following sentence, such representative shall have full access to
all  operations,  documents,  and  records  that  specifically  pertain  to  the
manufacture  of the Products.  The Customer  Representative  shall accept INyX's
procedures regulating external customer  relationships  (including GMP training,
guarantee of confidentiality,  and health procedures),  and shall not materially
disrupt INyX's operations.

                                   ARTICLE 3
                               PLANNING AND SUPPLY
                               -------------------

3.1   Production
      ----------

INyX will produce  Products to meet the mutually agreed upon forecasts,  subject
to the provisions of this Article 3. INyX will keep the Customer informed of all
scheduled production activity for the Products.

3.2   Termination of Obligation
      -------------------------

INyX's obligation to supply Product to the Customer shall terminate  pursuant to
the provisions of Article 10 below.

3.3   Forecasts
      ---------

The Customer  shall  provide  INyX with an annual  forecast  for  budgeting  and
production planning purposes.  The Customer shall also deliver to INyX a monthly
update,  including  a 90-day  rolling  forecast  setting  forth  the  Customer's
required quantities and delivery dates for each Product. Forecasts shall include
the  amounts of each  Product to be  manufactured  and  supplied by INyX and the
expected  timing for the delivery of each shipment  during the forecast  period.
The Parties shall discuss each of the forecasts and shall mutually agree in good
faith on the  appropriateness  of each forecast  versus  anticipated  demand for
Product.

3.4   Purchase Orders
      ---------------

The  Customer  will place  written  purchase  orders  directly  or  through  its
designated  representatives  with INyX approximately 10 weeks prior to requested
shipment  date,  including the  following  details:  number of units,  requested
shipping date,  shipping  instructions and the

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<PAGE>

Customer's order reference  number  including the price calculated  according to
this  Agreement.  Each purchase order issued pursuant to this Agreement shall be
governed by the terms and conditions of this  Agreement,  and shall override any
conflicting  provisions  in any invoice or packing  slip  generated by INyX with
respect to the details set forth in this Section 3.4.

3.5   Receipt and Acceptance by INyX
      ------------------------------

INyX shall promptly  acknowledge  its receipt of purchase  orders and inform the
Customer of the  anticipated  dates of manufacture  and delivery of each Product
presentation to the Customer. INyX shall respond in writing as to its acceptance
of each firm purchase  order within  fifteen (15) days of receipt of such order.
Any portion of the order that exceeds the most recent  corresponding twelve (12)
month forecast  (supplied  pursuant to Section 3.3) by more than one hundred ten
percent (110%) will be accepted at INyX's discretion. Once a specified quantity,
form and delivery  date terms have been agreed to by the Parties in any purchase
order  placed  pursuant  to this  Section  3.5,  the  purchase  order may not be
canceled by either  Party  except as provided in Section 3.10 or in Section 3.11
below.

3.6   Shipment; Delays
      ----------------

INyX shall use Commercially  Reasonable  Efforts to ship Product to the Customer
by the delivery date specified in the accepted  purchase order. If INyX believes
there will be a  significant  delay in shipment of Finished  Product  beyond the
delivery dates  specified in any accepted  purchase  order,  INyX shall promptly
inform the Customer of such expected delay and shall use Commercially Reasonable
Efforts to minimize the delay.

3.7   Change Orders
      -------------

The time of delivery and  quantities  specified in a purchase  order accepted by
INyX pursuant to Section 3.5 above shall be binding upon the Parties and may not
be changed or canceled, except as provided in Sections 3.9 and 3.10 below.

3.8   Increased Demand
      ----------------

INyX will use  Commercially  Reasonable  Efforts to  accommodate  the Customer's
requests for units in excess of those reserved for the Customer and set forth in
Exhibit B to this Agreement; provided, however, that it shall not be a breach of
this Agreement if INyX, despite its Commercially  Reasonable  Efforts, is unable
to supply  quantities of Product to the Customer in excess of 110% of the annual
forecast supplied pursuant to Section 3.3 for that year.

3.9   Postponement of Manufacturing; Penalties
      ----------------------------------------

      (a)   By the  Customer.  The Customer  may  postpone a purchase  order for
            production in accordance  with the  provisions in this Section.  The
            Customer may postpone each purchase  order one time. In the event of
            postponement pursuant to this Section

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<PAGE>

            3.9, INyX shall use  Commercially  Reasonable  Efforts to reschedule
            the postponed order to a date agreeable to both Parties.  Regardless
            of the amount of notice,  if the Customer  does not  reschedule  the
            Date of Manufacture to a date within  forty-five  (45) calendar days
            of the originally scheduled date, the purchase order shall be deemed
            cancelled,  and shall  accrue the  penalties,  if any,  pursuant  to
            Section 3.10.

      (b)   By INyX.

            (i)   INyX  shall use  Commercially  Reasonable  Efforts to meet the
                  terms of a purchase order that it accepts, taking into account
                  mutually  agreed upon forecasts  under Section 3.3,  available
                  plant capacity and timing of its production.

            (ii)  If INyX fails to meet the  deadlines  specified  in a purchase
                  order that it has accepted,  or specified in its acceptance of
                  the  purchase  order,  and the  failure is caused by the gross
                  negligence or willful  misconduct  of INyX,  then the Customer
                  may  require  INyX to supply  the  undelivered  Product at the
                  earliest  possible future date (subject to a penalty of 15% of
                  the cost of such  undelivered  Product for each month's delay)
                  unless otherwise  agreed by the Customer,  or the Customer may
                  at  its  option  cancel  such  portion  of the  order  without
                  penalty.

3.10  Cancellation of Purchase Orders; Penalties
      ------------------------------------------

The Customer may cancel a purchase order for  production in accordance  with the
provisions  in this  Section.  The charge for  cancellation  shall be determined
according to the following schedule:

      (a)   If the  Customer  gives at least  ninety (90)  calendar  days notice
            prior to the manufacturing date assigned by INyX pursuant to Section
            3.5, there shall be no penalty for cancellation.

      (b)   If the Customer  gives less than sixty (60)  calendar  days and more
            than twenty-one (21) days notice, INyX may invoice the Customer for,
            and the Customer shall be

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<PAGE>

            required to pay to INyX an amount equal to thirty  percent  (30%) of
            the amount owed under the purchase  order,  calculated in accordance
            with Exhibit B; provided,  however,  that INyX must use Commercially
            Reasonable  Efforts to reallocate the suite to  manufacture  another
            product of similar value to INyX on the originally  scheduled  date,
            and no charge  shall be assessed to the Customer if such efforts are
            successful.

      (c)   If the  Customer  gives twenty one (21) days or less notice but more
            than  fourteen  (14) days notice INyX may invoice the Customer  for,
            and the Customer shall be required to pay to INyX an amount equal to
            fifty  percent  (50%) of the amount owed under the  purchase  order,
            calculated in accordance  with Exhibit B;  provided,  however,  that
            INyX must use  Commercially  Reasonable  Efforts to  reallocate  the
            suite to manufacture another product of similar value to INyX on the
            originally  scheduled  date,  and no charge shall be assessed to the
            Customer if such efforts are successful.

      (d)   If the  Customer  gives  less  than  fourteen  (14)  days  notice of
            cancellation,  INyX may invoice the  Customer  for, and the Customer
            shall be  required to pay,  an amount  equal to one  hundred  (100%)
            percent of the amount owed under the purchase  order,  calculated in
            accordance with Exhibit B.

3.11  Shipment; Inspection; Rejection
      -------------------------------

      (a)   Shipment of Product.  INyX shall ship, or cause to be shipped at the
            Customer's   expense,   the   Product  to  the   Customer   or  such
            destination(s) as the Customer may designate in writing. Delivery of
            Product  to a  common  carrier  authorized  by  the  Customer  shall
            constitute delivery to the Customer,  and risk of loss shall pass to
            the Customer at that time.  INyX agrees to provide support to assist
            the  Customer  to  pursue  any  Product  related  claims it may have
            against  carriers,  provided that the Customer shall  reimburse INyX
            for any  out-of-pocket  expenses  INyX may incur in  providing  such
            support.  All invoices and other shipping documents shall be sent by
            first  class mail or by fax to the  Customer's  address  for notices
            under  this  Agreement,  directed  to the  attention  of  Purchasing
            Department, Stiefel Laboratories, Inc., 6290 Route 145, Oak Hill, NY
            12460.

      (b)   Non-Conforming Product. The Customer may reject any batch of Product
            that does not conform to the  Manufacturing  Standards,  or that has
            less than eighteen (18) months remaining before its expiration date,
            subject  to the terms of this  Section  and the  Quality  Agreement.
            Within  thirty (30) days after INyX's  internal  release of Product,
            the  Customer  shall  inspect the Product and notify INyX whether it
            will accept or reject the Product.  No inspection under this Section
            shall  relieve INyX of its  obligations  and  warranties  under this
            Agreement.  If the Customer  rejects all or any part of any shipment
            of Product, the procedures to be followed are:

            (i)   the  Customer  shall  submit to INyX in writing any claim that
                  the Product does not conform  with the Product  Specifications
                  or cGMPs,  accompanied by a report of the Customer's  analysis
                  (which analysis shall be conducted in good faith) and a sample
                  of the Product at issue,  explaining in reasonable  detail the
                  basis on which the  allegedly  nonconforming  Product does not
                  meet  the  Product  Specifications.   Once  nonconformance  is
                  confirmed  and fault is  determined  to belong with INyX,  the

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<PAGE>

                  Customer shall not be obligated to pay for such  nonconforming
                  shipment  of Product.  Only those tests  listed in the Product
                  Specifications  may be used to demonstrate  nonconformance  of
                  Product.

            (ii)  INyX  shall  conduct  its own  analysis  of the sample in good
                  faith within thirty (30) days after the receipt by INyX of the
                  report and sample from the  Customer,  and provide the results
                  to the Customer.

                  (A)   If after  INyX's own  analysis of the sample INyX agrees
                        with the  claim of  nonconformity,  the  Customer  shall
                        promptly inform INyX if the Customer wishes to have INyX
                        replace  the   nonconforming   Product  with  conforming
                        Product.   If  the  Customer   wishes  to  receive  such
                        replacement Product, INyX shall provide such replacement
                        as soon as reasonably practicable  thereafter,  in which
                        case the  Customer  shall be  obligated  to pay only for
                        such  replacement  Product.  The  Customer  shall not be
                        obligated to pay for the nonconforming Product, and INyX
                        shall:  (1) credit the  Customer  for the amount paid by
                        the  Customer to INyX for the  nonconforming  Product if
                        the  Customer  has already  paid for such  nonconforming
                        Product or (2) cancel its  invoice to the  Customer  for
                        such  nonconforming  Product if the Customer has not yet
                        paid for such  nonconforming  Product,  and the Customer
                        shall not be  obligated to pay such  cancelled  invoiced
                        amount.

                  (B)   If, after its own analysis, INyX does not agree with the
                        claim of  nonconformity  or determines that the Customer
                        is responsible for the nonconformity, such Product shall
                        be tested for  conformance  with the applicable  Product
                        Specifications  by an  independent  third party  testing
                        laboratory  mutually  acceptable  to both  Parties.  The
                        independent  analysis  shall be binding on both  Parties
                        solely  for the  purpose  of  determining  whether  such
                        Product may be rightfully rejected.

            (iii) After a final determination that the Product shipment is:

                  (A)   nonconforming,  and  if  INyX  is  responsible  for  the
                        nonconformity,  the Customer  shall return or destroy it
                        at INyX's  request  and cost in the most cost  effective
                        and   environmentally   safe  and   appropriate   manner
                        available, consistent with federal, state and local laws
                        and regulations;

                  (B)   conforming,  the Customer  shall  forthwith pay INyX for
                        such  Product  in  accordance  with  the  terms  of this
                        Agreement.

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<PAGE>

            (iv)  If conforming  Product  supplied under this Agreement  becomes
                  nonconforming  or unsuitable at no fault of INyX, the Customer
                  will remain obligated to pay INyX for such Product.  At INyX's
                  request,  the Customer shall return such unsuitable Product to
                  INyX.  Otherwise,  the Customer  shall  destroy it in the most
                  environmentally   safe  and  appropriate   manner   available,
                  consistent with federal, state and local laws and regulations.

      (c)   Notwithstanding  the other  provisions  of this  Section  3.11,  the
            Customer  shall  have no right to reject any  Product  that fails to
            conform with the  Manufacturing  Standards if the  nonconformance is
            attributable  to (i) events  outside of INyX's control that occurred
            after delivery to a common carrier, or (ii) processes, procedures or
            Product  components   specified  by  the  Customer  in  the  Product
            Specifications,  provided that INyX followed or used such processes,
            procedures and Product components  materially in accordance with the
            Product Specifications.

3.12  Unique Materials
      ----------------

The Customer shall reimburse INyX for its actual costs expended for the purchase
of "Unique  Materials"  (i.e.,  certain raw  materials,  artwork,  printed cans,
labels,  cartons and special  valves)  purchased  by INyX  expressly to meet its
performance  obligations  under this  Agreement in reliance upon a firm purchase
order  pursuant  to Section  3.4 and which  later are made  obsolete,  or to the
extent  that such  Unique  Materials  remain on hand at the  expiration  of this
Agreement as provided under Section 10.1. For purposes of this Section, material
is  obsolete  if it cannot  be  incorporated  into the  Product  due to  changes
mandated by a Regulatory  Authority,  changes  directed by the Customer,  or the
Customer-mandated cancellation or postponement.  Once material becomes obsolete,
INyX may  invoice  the  Customer  for the  acquisition  costs  of such  obsolete
material  from time to time,  which  invoices  shall  identify  the  material in
question  and shall be  accompanied  by a reasonably  detailed  statement of the
cause of such  obsolescence  and a certification  that INyX has disposed of such
materials in accordance with the terms of this Agreement.

3.13  Risk of Losz
      ------------

Risk of loss of Product shall be with INyX until delivery of Product to a common
carrier  pursuant  to  Section  3.11  of  this  Agreement.  Notwithstanding  the
forgoing,  INyX shall not be liable  for loss of  Product  caused by an event of
force majeure or the Customer's negligence or willful misconduct.

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<PAGE>

3.14  Insurance
      ---------

INyX shall at its own expense  obtain and  maintain  workers'  compensation  and
comprehensive general liability insurance with respect to performance under this
Agreement,   in  the   amount   of  Five   Million   British   Pounds   Sterling
((pound)5,000,000).

                                   ARTICLE 4
                             PRICE AND PAYMENT TERMS
                             -----------------------

4.1   Price for Products
      ------------------

The  Customer  shall pay INyX for  Products  in  amounts  to be agreed  for each
Product and for each size or formulation. The agreed upon price for each Product
shall be set forth in the  document  attached  as  Exhibit B to this  Agreement,
which Exhibit may be amended from time to time by the mutual  written  agreement
of the Parties.

4.2   Invoices
      --------

INyX shall submit to the Customer an invoice five (5) days after INyX's internal
release of Product.  The  Customer  shall make  payment of each  invoice  within
forty-five  (45) days after receipt by the Customer.  If within  forty-five (45)
days after the delivery of Product and the accompanying  Certificate of Analysis
to the Customer,  the Customer  demonstrates  non-conformance under Section 3.11
and INyX agrees with such  finding,  the Customer  shall not be obligated to pay
for such non-conforming shipment.

4.3   Exclusivity
      -----------

The  Parties  agree to deal with each  other  exclusively  with  respect  to the
manufacture   and  supply  of  topical  and  foam  aerosol   products  used  for
dermatological   applications  (together  with  *  *  *  ,  the  "Dermatological
Products")  during  the  term  of this  Agreement  (the  "Exclusivity  Period"),
including extensions and renewals thereof. This exclusivity arrangement:

      (a)   shall  not apply to the  manufacture  and  supply of  Dermatological
            Products in respect of the current  customers of INyX  (formerly the
            customers of Miza  Pharmaceuticals,  Inc. and its subsidiaries) such
            Dermatological  Products  and  customers  to be set  out in  Exhibit
            4.3(a). INyX shall be free to continue to supply such Dermatological
            Products to such customers; and

      (b)   may, at the request of INyX,  be suspended  for the  manufacture  of
            certain  Dermatological  Products upon  obtaining the consent of the
            Customer, such consent not to be unreasonably withheld.

4.4  * * *

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<PAGE>

4.4   Currency
      --------

Amounts due to INyX under this Agreement are payable in U.S.  Dollars,  based on
the average  exchange  rate  published in the Wall Street  Journal from ten (10)
days prior through the date of the Customer's first rolling forecast provided to
INyX pursuant to Section 3.3 above.  If the exchange rate  published in the Wall
Street Journal from ten (10) days prior through the date of a subsequent six (6)
month rolling  forecast differs by more than five percent (5%) from the exchange
rate  then  prevailing  between  the  Parties,  the  Party  against  which  such
difference  works may,  within ten (10) days,  request a  renegotiation  of such
exchange  rate with the other Party.  The  difference  in any such  renegotiated
exchange rate not to exceed fifty percent (50%) of the  difference  between said
then-prevailing and published exchange rates.

4.5   Set-Off
      -------

The parties  acknowledge  that,  INyX has made a convertible  promissory note of
even date in favour of the  Customer in the face  amount of  (pound)2,500,000.00
British Pounds Sterling (the "Promissory  Note").  INyX agrees that the Customer
may,  from time to time, at its sole  discretion,  set-off  against  amounts due
hereunder any overdue  interest or principal  payments  accruing due pursuant to
the  Promissory  Note,  upon providing INyX ten (10) business days notice of the
Customer's  intention  to set-off such  amounts;  and to permit INyX to cure any
default under the Promissory Note as provided therein.

                                    ARTICLE 5
                                   WARRANTIES
                                   ----------

5.1   Quality
      -------

Each shipment of Product under this Agreement  shall have been  manufactured  in
accordance  with U.S.  Current Good  Manufacturing  Practices in a duly licensed
facility  and shall have been  subject to a quality  control  inspection  by the
Customer in accordance with the Product  Specifications  and with the Customer's
then current  quality  control  standards  and  systems.  INyX shall number each
Product  shipment  with a vendor lot number that is traceable  to raw  materials
and/or components used to manufacture such Product.

5.2   Representations and Warranties
      ------------------------------

      (a)   INyX  warrants  that Product  delivered to the Customer  pursuant to
            this Agreement shall, at the time of delivery:

            (i)   have been manufactured,  filled, packaged,  stored and shipped
                  in accordance with all applicable laws, rules,  regulations or
                  requirements;

            (ii)  have  been  manufactured,   filled,  packaged  and  stored  in
                  accordance   with,   and  will   conform   to,   the   Product
                  Specifications;

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<PAGE>

            (iii) will be free  from  defects  in  material,  manufacturing  and
                  workmanship  for the shelf life of the Product as set forth in
                  the Product Specifications;

            (iv)  not be  adulterated  or  misbranded  within the meaning of the
                  Federal Food, Drug and Cosmetic Act (the "Act") as amended, or
                  within the meaning of any applicable state or municipal law in
                  which the  definitions of  adulteration  and  misbranding  are
                  substantially  the same as those  contained in the Act, as the
                  Act and such laws are constituted and effective at the time of
                  delivery; and

            (v)   will not be an article which may not,  under the provisions of
                  Sections 404 and 505 of the Act, be introduced into interstate
                  commerce.

      (b)   Licensing.  INyX  represents  and warrants  that it has obtained and
            will  maintain on a current basis and will comply with all licenses,
            permits and approvals of applicable  governmental agencies as may be
            required to manufacture, test and store the Product pursuant to this
            Agreement and perform its other  obligations  under this  Agreement.
            INyX shall be responsible for obtaining and maintaining licenses and
            permits  for  manufacture,  testing  and  storage of the Product and
            ensuring that its facilities  used in the manufacture of the Product
            meet cGMPs in all respects.

      (c)   Compliance  with Laws.  INyX  represents  and warrants that it shall
            comply with all federal,  state, local and foreign laws, regulations
            and other  requirements  applicable to the manufacture,  testing and
            storage of the Product  and the  performance  of INyX's  obligations
            under  this  Agreement.  INyX  shall  have sole  responsibility  for
            adopting  and  enforcing  safety  procedures  for the  handling  and
            manufacture of the Product at its facilities and the proper handling
            and proper disposal of waste relating to the Product.

5.3   Limitations; Indemnification
      ----------------------------

      (a)   Limitations  on Warranty.  The warranty  furnished in this Article 5
            shall not apply to defects  caused by  accident  or willful  damage,
            abuse, misuse, neglect, improper testing,  handling,  storage or use
            after delivery by INyX of the Product in question to the Customer.

      (b)   No Implied  Representations;  Warranties  or  Conditions.  EXCEPT AS
            OTHERWISE EXPRESSLY PROVIDED IN THIS AGREEMENT, NEITHER INYX NOR THE
            CUSTOMER  MAKES ANY  REPRESENTATIONS  OR WARRANTIES AND THERE ARE NO
            CONDITIONS, EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, WITH RESPECT
            TO  PRODUCT  SUPPLIED  UNDER  THIS  AGREEMENT,   INCLUDING,  WITHOUT

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<PAGE>

            LIMITATION,  ANY  REPRESENTATIONS,  WARRANTIES  OR  CONDITIONS  WITH
            RESPECT  TO  NONINFRINGEMENT,   MERCHANTABILITY  OR  FITNESS  FOR  A
            PARTICULAR  PURPOSE OF SUCH  PRODUCT,  OR  ARISING  FROM A COURSE OF
            DEALING OR USAGE OF TRADE PRACTICE.

      (c)   Limitation of Liability.  EXCEPT FOR ANY LOSS, LIABILITY,  DAMAGE OR
            OBLIGATION   ARISING  OUT  OF  OR  RELATING  TO  THE  DISCLOSURE  OF
            CONFIDENTIAL  INFORMATION  PURSUANT  TO  ARTICLE  7 OR AS  OTHERWISE
            EXPRESSLY  SET FORTH IN THIS  AGREEMENT,  IN NO EVENT  SHALL  EITHER
            PARTY HAVE ANY LIABILITY TO THE OTHER PARTY OR ANY OTHER THIRD PARTY
            FOR ANY LOST  OPPORTUNITY,  COSTS OF PROCUREMENT OF SUBSTITUTE GOODS
            OR  SERVICES,  OR  FOR  ANY  INDIRECT,  INCIDENTAL,   CONSEQUENTIAL,
            PUNITIVE OR SPECIAL DAMAGES ARISING OUT OF THIS AGREEMENT, UNDER ANY
            CAUSE OF ACTION OR THEORY OF LIABILITY (INCLUDING  NEGLIGENCE),  AND
            WHETHER OR NOT SUCH PARTY TO THIS  AGREEMENT HAS BEEN ADVISED OF THE
            POSSIBILITY   OF  SUCH  DAMAGE.   THESE   LIMITATIONS   SHALL  APPLY
            NOTWITHSTANDING  ANY  FAILURE OF  ESSENTIAL  PURPOSE OF ANY  LIMITED
            REMEDY.  INYX'S  MAXIMUM  LIABILITY  UNDER THIS  AGREEMENT  SHALL BE
            LIMITED  TO THE  INYX'S  ACTUAL  RECOVERY  UNDER  ITS  COMPREHENSIVE
            GENERAL  LIABILITY  INSURANCE  WHICH AS OF THE DATE HEREOF CARRIES A
            COVERAGE OF FIVE MILLION BRITISH POUNDS STERLING.

      (d)   INyX shall use  commercial  efforts  in  pursuing  claims  under its
            comprehensive  general  liability  insurance in order to  reasonably
            permit the Customer to recover  losses,  as its interest may appear,
            pursuant to this Agreement.  Upon the Customer's request, INyX shall
            assign to the  Customer  (to the  extent it can  legally  do so) its
            rights to  insurance  proceeds,  provided  the  Customer has a valid
            claim   against   INyX   under   this   Agreement   that  is  either
            unconditionally  admitted by INyX or is otherwise  finally confirmed
            by court action or other dispute resolution process.

                                   ARTICLE 6
                               TECHNOLOGY TRANSFER
                               -------------------

6.1   Second Source
      -------------

INyX  shall  assist  the  Customer  (at the  Customer's  cost  and  expense)  in
qualifying  a second  source for Product,  providing  technical  assistance  and
documentation as necessary, including

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                                                                         Page 15
<PAGE>

such  manufacturing  technology  and know-how so as to permit  another entity to
manufacture  Product,  and  INyX  agrees  to  cooperate  with  the  Customer  to
facilitate the technology transfer.

6.2   Reimbursement
      -------------

The Customer  agrees to  reimburse  INyX for INyX's  expenses in  providing  the
assistance required in Section 6.1 for any second source other than an Affiliate
of INyX.

6.3   Intellectual Property
      ---------------------

INyX shall use Commercially  Reasonable  Efforts to assist the Customer with the
preparation  and filing of patent  applications in connection with the Products;
provided that, the Customer shall reimburse INyX for all out-of-pocket costs and
expenses incurred by INyX.

For greater clarity,  INyX acknowledges  that all intellectual  property created
specifically  in  connection  with the Products (the  "Intellectual  Property"),
including  formulations,  inventions  or  discoveries  (first made or reduced to
practice  in the  performance  of  INyX's  obligations  hereunder)  shall be the
property of the Customer.  INyX shall,  when requested by the Customer,  execute
all such  assignments,  consents  and other  documents  reasonably  necessary to
assign  to the  Customer  all  right,  title  and  interest  in  and to all  the
Intellectual Property, and shall use best efforts to cause its employees, agents
and  subcontractors  to execute the  necessary  documents to give effect to this
provision.

The Customer hereby grants INyX a royalty-free,  non-exclusive,  worldwide right
and license to make, use and sell products incorporating  Intellectual Property,
subject always to INyX's obligations hereunder.

                                   ARTICLE 7
                                 CONFIDENTIALITY
                                 ---------------

7.1   Confidentiality
      ---------------

      (a)   Confidential Information.  The Parties acknowledge that by reason of
            their  relationship  to each other under this  Agreement,  each will
            have access to certain  information  and  materials  concerning  the
            other's business,  plans, trade secrets,  customers (including,  but
            not limited to, customer lists), technology, and/or products that is
            confidential  and of  substantial  value to that Party,  which value
            would  be  impaired  if such  information  were  disclosed  to Third
            Parties ("Confidential Information"). Each Party agrees that it will
            not use in any way other than expressly  authorized or  contemplated
            under this  Agreement,  nor  disclose to any third  party,  any such
            Confidential  Information  revealed to it by the other Party (except
            that Confidential  Information may be disclosed, as required for the
            purposes  of  this  Agreement,   to  any  Regulatory  Authority,  an

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<PAGE>

            Affiliate,   assignee,   distributor,   consultant  or  third  party
            contractor or research and  development  organization  under similar
            written  obligations of non-disclosure  and non-use),  and will take
            every reasonable  precaution to protect the  confidentiality of such
            information and with no less  restrictive  precautions than it takes
            to  protect  its  own  confidential  information.   If  Confidential
            Information is required to be disclosed in response to a valid order
            by a  court,  Regulatory  Authority  or  other  government  body  of
            competent jurisdiction,  or if otherwise required to be disclosed by
            law, or if necessary  to establish  the rights of either Party under
            this Agreement,  the receiving Party shall use reasonable efforts to
            provide the  disclosing  Party with advance  notice of such required
            disclosure to give the disclosing  Party  sufficient  time to seek a
            protective order or other protective measures, if any are available,
            for such Confidential Information.

      (b)   Exceptions.  For purposes of this  Agreement,  information  shall be
            deemed Confidential  Information if such information,  by its nature
            or due to the context  within  which it is  disclosed,  is obviously
            intended by the disclosing Party to be kept confidential even if not
            identified as such in writing or with legends or other markings. The
            person disclosing Confidential Information shall endeavor to confirm
            verbally disclosed  Information as "CONFIDENTIAL" in writing,  given
            the  understanding  that  failure  to do so does  not  constitute  a
            designation   of   non-confidentiality,    particularly   when   the
            confidential  nature is apparent  from  context and subject  matter.
            Upon request by a Party,  the other Party will advise whether or not
            it  considers  any   particular   information  or  materials  to  be
            Confidential Information.  Confidential Information does not include
            information, technical data or know-how that:

            (i)   is or  becomes  publicly  available  through  no  fault of the
                  receiving Party or its individual employees, agents or members
                  amounting to a breach of this Agreement;

            (ii)  is  lawfully  obtained  on a  non-confidential  basis  by  the
                  receiving  Party from a third  party who is not  obligated  to
                  retain such information in confidence;

            (iii) the receiving Party can  demonstrate,  by competent  evidence,
                  was known to it or any of its  Affiliates  from a source other
                  than the disclosing  Party or any of its  Affiliates  prior to
                  the disclosure under this Agreement;

            (iv)  the receiving  Party can demonstrate by its written records is
                  independently developed by employees of the receiving Party or
                  an Affiliate of the  receiving  Party,  which  employees  were
                  neither   privy  to  nor  had   access  to  the   Confidential
                  Information  and which is developed  without use in any way of
                  the Confidential Information;
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<PAGE>

            (v)   must be disclosed to governmental agencies, provided that: (A)
                  this  exception   shall  only  apply  to  disclosure  to  such
                  agencies,  and not to any other person or entity;  and (B) the
                  disclosing Party shall (1) provide the other Party with prompt
                  notice  (including  copies of all written requests or demands)
                  of any proposed disclosure to any governmental agency, with an
                  explanation of the Confidential Information of the other Party
                  to be disclosed; and (2) cooperate in any lawful effort by the
                  other Party to prevent,  limit or restrict  disclosure  of its
                  Confidential Information to such government agency.

7.2   Remedy
      ------

If either Party breaches any of its obligations  with respect to this Article 7,
or if such a breach is likely to occur,  the other  Party  shall be  entitled to
seek equitable  relief,  including  specific  performance  or an injunction,  in
addition to any other rights or remedies,  including money damages,  provided by
law, without posting a bond.

7.3   Agreement Terms
      ---------------

Subject to Section  15.2 and the  exclusions  set forth in Section  7.1(b),  the
Parties shall treat the terms and conditions of this  Agreement as  Confidential
Information;  provided,  however, after written notification to the other Party,
each Party may disclose the existence of this  Agreement and the material  terms
and conditions of this Agreement under  circumstances that reasonably ensure the
confidentiality  thereof  to:  (a) any  government  or  regulatory  authorities,
including without limitation the United States Security and Exchange  Commission
pursuant  to  applicable  law  (excluding,  to  the  extent  legally  permitted,
disclosure of financial terms in any publicly  available versions of information
so  disclosed),   (b)  its  legal  representatives,   advisors  and  prospective
investors,  and (c) to the  Customer's  licensors  to the  extent  required  for
compliance with the Customer's obligations under third party licenses.

7.4   Return of Confidential Information
      ----------------------------------

Within ten (10) days  following the  termination  of any  agreement  between the
Parties  with  respect to the  subject  matter  the  receiving  Party  agrees to
promptly  return all tangible  items relating to the  Confidential  Information,
including all written material, photographs, models, compounds, compositions and
the like made  available or supplied by the  disclosing  Party to the  receiving
Party, and all copies thereof,  upon the request of the disclosing Party, except
such  records  as may be  required  to be  kept  for  FDA  or  other  government
regulatory  compliance.  Recipient  further  agrees to identify those persons to
whom the  Confidential  Information  that is the subject of this  Agreement  was
disclosed upon request of the disclosing Party.
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<PAGE>

7.5   Inside Information
      ------------------

INyX  understands   that   Confidential   Information  may  constitute   "inside
information" of the Customer for securities  purposes and agrees to refrain from
any unlawful disclosure, trading or other improper use of such information.

7.6   Connetics Information
      ---------------------

Miza  Pharmaceuticals,  Inc.  has,  to the best of INyX's  knowledge  (after due
enquiry),  returned to Connetics  Corporation  all  Confidential  Information of
Connetics   Corporation  under  the  provisions  of  the  Amended  and  Restated
Manufacturing  and Supply  Agreement  between  Miza  Pharmaceuticals,  Inc.  and
Connetics Corporation dated September 19th, 2001.

                                   ARTICLE 8
                                   ASSIGNMENT
                                   ----------

8.1   Assignment by INyX
      ------------------

INyX shall have no right or authority to assign the  Agreement or any portion of
the  Agreement,  to  sublet or  subcontract  in whole or in part,  or  otherwise
delegate its  performance  under this  Agreement,  without the Customer's  prior
written consent, such consent not to be unreasonably  withheld.  Notwithstanding
the foregoing, nothing in this Agreement shall prohibit INyX from assigning this
Agreement to any Affiliate of INyX that may from time to time own or operate the
facility at Runcorn,  England.  No such assignment shall relieve INyX of primary
liability for the performance of its obligations under this Agreement.

8.2   Assignment by the Customer
      --------------------------

The Customer may assign this  Agreement.  INyX agrees that if this  Agreement is
assigned to any third party or Affiliate,  all the terms and  conditions of this
Agreement  shall obtain  between such third party or Affiliate and INyX with the
same force and effect as if said  Agreement  had been made with such third party
or Affiliate  in the first  instance,  provided  that no such  assignment  shall
relieve  the  Customer  of primary  liability  for the due  performance  of this
Agreement.

                                   ARTICLE 9
                                  FORCE MAJEURE
                                  -------------

9.1   Force majeure
      -------------

Neither Party shall be considered in default of performance  of its  obligations
under  this  Agreement,  except any  obligation  under  this  Agreement  to make
payments when due, to the extent that performance of such obligations is delayed
by contingencies  or causes beyond the reasonable  control and not caused by the
negligence  or willful  misconduct  of such Party,  including but not limited to
strike,  fire,  flood,  earthquake,  windstorm,  governmental  acts

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<PAGE>

or orders or restrictions,  or force majeure,  to the extent that the failure to
perform is beyond the  reasonable  control of the  nonperforming  Party,  if the
Party  affected  shall give prompt written notice of any such cause to the other
Party.  The Party giving such notice shall thereupon be excused from such of its
obligations under this Agreement for the period of time that it is so disabled.

                                   ARTICLE 10
                              TERM AND TERMINATION
                              --------------------

10.1  Term
      ----

This Agreement shall expire on March 6, 2007 (the "Initial  Term"),  after which
this Agreement may be renewed for successive  periods of one calendar year each,
any such  agreement to renew to be  confirmed in writing by the Parties.  At the
end of the  Initial  Term,  this  Agreement  shall,  at the  Customer's  option,
automatically  renew for  successive  one-year  periods under the same terms and
conditions set forth under this Agreement (or such other terms agreed in writing
by the Parties) until terminated in writing in accordance with the provisions of
this Agreement.

10.2  Termination for Material Breach
      -------------------------------

Either Party may terminate this Agreement upon written notice if the other Party
has breached any of its material obligations under this Agreement,  and (a) such
breach has not been cured within 60 days after written notice of the breach,  or
(b)  if a  plan,  reasonably  acceptable  to  the  non-breaching  Party,  is not
implemented to cure as soon as practicable after notice of the breach

10.3  Termination upon Insolvency
      ---------------------------

Either Party may, in addition to any other remedies available to it by law or in
equity,  terminate  this  Agreement  immediately  by written notice to the other
Party  upon (i) the  filing  by the  other  Party  of a  voluntary  petition  in
bankruptcy  or seeking  reorganization,  liquidation,  dissolution,  winding-up,
arrangement,  composition or readjustment of its debts or any other relief under
any bankruptcy,  insolvency,  reorganization  or other similar act or law of any
jurisdiction  now or  hereafter  in effect,  (ii) the filing  against such other
Party of an involuntary  petition in bankruptcy which is not dismissed within 60
days,  (iii) the  appointment  of a  receiver  or  trustee  of any of such other
Party's  property if such  appointment is not vacated  within 60 days,  (iv) the
adjudication  of such other Party as  insolvent,  or (v) the  assignment of such
other Party's property for the benefit of its creditors.

10.4  Termination for Force Majeure
      -----------------------------

Either Party may terminate  this  Agreement  upon thirty (30) days written prior
notice in the event of the other Party's inability to substantially  perform its
obligations under this Agreement for more than one hundred eighty (180) days due
to an event of force majeure as described in Article 9.

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10.5  Termination without Cause
      -------------------------

Either Party may  terminate  this  Agreement  upon twelve (12)  months'  written
notice to the other Party.

10.6  Accrued Liabilities
      -------------------

The  termination  of this  Agreement for any reason shall not  discharge  either
Party's  liability for  obligations  incurred  under this  Agreement and amounts
unpaid at the time of such termination. The Customer shall be liable to pay INyX
for any Product, work in progress and materials purchased by INyX to fulfill its
obligations  under this  Agreement,  provided  however  that INyX shall make all
Commercially   Reasonable   Efforts  to   mitigate   its   damages   under  such
circumstances.

10.7  Return and Disposition of Property
      ----------------------------------

Upon the  termination of this Agreement for any reason,  each Party shall return
to the  other  Party  or  its  designee  all of  such  other  Party's  property,
including, but not limited to, all proprietary  information,  in its possession.
To the  extent  required  by law  or to  comply  with  such  Party's  continuing
obligations under this Agreement,  each Party may keep a single copy of tangible
property  belonging  to the other Party.  INyX shall  dispose of all bulk active
ingredients,  raw materials,  containers, and Labeling not necessary to complete
work in progress at the  Customer's  expense in accordance  with the  Customer's
reasonable instructions.

                                   ARTICLE 11
                                 INDEMNIFICATION
                                 ---------------

11.1  Indemnification by INyX
      -----------------------

INyX shall,  subject to Section 5.3, indemnify the Customer,  its Affiliates and
their respective directors,  officers, employees and agents, and defend and save
each of them  harmless,  from and  against any and all suits,  losses,  actions,
demands,  investigations,  claims,  damages,  liabilities,  costs  and  expenses
(including,  without  limitation,   reasonable  attorneys'  fees  and  expenses)
(collectively, "Losses") brought by third parties arising from or occurring as a
result of:

      (a)   a  nonconformity  of Product with the warranties  under Sections 5.1
            and 5.2 except for any damages attributable to the negligence of the
            Customer, its employees or agents;

      (b)   INyX's failure to comply with the Product Specifications;

      (c)   any willful act or omission or negligence of INyX or its  employees,
            agents or other  contractors in the manufacturing and testing of the
            Product; or

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<PAGE>

      (d)   INyX's failure to comply with the Act and the regulations  under the
            Act in the production of Product.

      (e)   any  breach  (or  alleged  breach)  by INyX of its  representations,
            warranties, or obligations under this Agreement;

      (f)   the  manufacture  or the storage of the Product prior to the date of
            shipment of Product to the Customer by INyX or its Affiliates,

      all except to the extent caused by the negligence or willful misconduct of
      the Customer or its officers, agents, employees, Affiliates, sublicensees
      or customers.

11.2  Indemnification by the Customer
      -------------------------------

The Customer shall,  subject to Section 5.3,  indemnify INyX, its Affiliates and
their respective directors,  officers, employees and agents, and defend and save
each of them  harmless,  from and  against  any and all Losses  brought by third
parties arising from or occurring as a result of:

      (a)   failure by the  Customer to comply  with the Food Drug and  Cosmetic
            Act and the regulations under the Act;

      (b)   the handling or other use of the Product;

      (c)   any willful act or omission  or  negligence  of the  Customer or its
            employees, agents or other contractors

      (d)   any   breach  (or   alleged   breach)   by  the   Customer   of  its
            representations, warranties, or obligations under this Agreement;

      (e)   the  manufacture by the Customer or third parties  contracted by the
            Customer,  or the  storage of Product  after the date of shipment of
            Product to the Customer by INyX or its Affiliates,

all except to the extent caused by the negligence or willful  misconduct of INyX
or its officers, agents, employees, Affiliates, sublicensees or customers.

11.3  Process
      -------

If either Party expects to seek  indemnification  from the other pursuant to the
provisions of this Article 11, it shall promptly give notice to the indemnifying
Party of any such Claim. The indemnifying  Party shall have the right to control
the defense of such Claim and the  indemnified  Party shall  cooperate  with the
indemnifying  Party in the defense of such Claim. No settlement or compromise of
any Claim shall be binding on a Party hereto without its prior written consent.

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                                                                         Page 22
<PAGE>

11.4  Patent Indemnification
      ----------------------

The  Customer  shall  indemnify  and hold INyX and its  employees,  servants and
agents harmless from and against any and all claims,  demands,  actions,  suits,
losses,  damages,  costs,  expenses (including  reasonable attorney's fees), and
liabilities which INyX may incur,  suffer or be required to pay by reason of any
patent  infringement suit brought against INyX because of INyX's  manufacture of
Product to the extent that the alleged  infringement  arose out of or related to
INyX's use of  processes,  compounds  or other  products the rights to which are
claimed to be owned by the Customer.

                                   ARTICLE 12
                            AUDIT RIGHTS; INSPECTIONS
                            -------------------------

12.1  Inspections
      -----------

The  Customer,  upon its own  discretion  and at its own cost  and  expense,  is
entitled  during  ordinary  business  hours and at dates  acceptable  to INyX to
inspect or to have  inspected,  INyX's plant and procedures used for manufacture
and storage of the Products.

12.2  Books and Records
      -----------------

INyX agrees to  maintain  and cause its  Affiliates  to  maintain  complete  and
accurate  books and  records of account so as to enable the  Customer  to verify
amounts due and payable under this Agreement. In particular, INyX shall preserve
and maintain  all such  records and accounts  required for audit for a period of
four (4) years after the calendar quarter for which the record applies.

12.3  Audit of INyX's Records
      -----------------------

During the term of this  Agreement,  the Customer  shall have the right upon two
(2) weeks notice to INyX to have an  independent  certified  public  accountant,
selected by the Customer and reasonably acceptable to INyX, audit INyX's records
during normal business hours; provided,  however, that such audit shall not take
place more frequently than once a year and shall not cover records for more than
the preceding four (4) years.

12.4  Government Inspection
      ---------------------

INyX agrees to advise the Customer by telephone and facsimile immediately of any
proposed or announced  visit or  inspection,  and as soon as possible but in any
case within  twenty-four (24) hours of any unannounced  visit or inspection,  by
any Regulatory  Authority of any facilities  used by INyX in the  performance of
its  obligations  under this  Agreement.  INyX shall provide the Customer with a
reasonable  description  of each such visit or  inspection  promptly  (but in no
event  later  than five 5  calendar  days)  thereafter,  and with  copies of any
letters,  reports or other  documents  (including Form 483's) issued by any such
authorities  that  relate to the  Products,  or

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<PAGE>

such  facilities,  processes  or  procedures.  The  Customer  may review  INyX's
responses  to any such  reports and  communications,  and if  practicable,  and,
insofar as timely received,  the Customer's  reasonable views and requests shall
be taken into account prior to submission of such reports and  communications to
the relevant Regulatory Authority.

                                   ARTICLE 13
                                    DISPUTES
                                    --------

13.1  Arbitration
      -----------

If the Parties' are unable to settle amicably any claim, dispute, controversy or
difference arising out of or in relation to or in connection with this Agreement
or for breach of this Agreement  through  consultation  and  negotiation in good
faith and a spirit of mutual  cooperation,  then the  dispute  shall be resolved
through  binding  arbitration  in  accordance  with the  rules  of the  American
Arbitration  Association then in effect. Judgment upon the award rendered by the
arbitrators  may be entered in any court  having  jurisdiction  thereof.  In any
arbitration  pursuant to this section, the award shall be rendered by a majority
of the members of a board of arbitration  consisting of three members, one being
appointed by each Party and the third being appointed by mutual agreement of the
two arbitrators  appointed by the Parties. The place of arbitration shall be New
York, New York.

13.2  UN Convention Not Applicable
      ----------------------------

The Parties  expressly  disclaim  application  to this  Agreement  of the United
Nations  Convention on Contracts for the International  Sale of Goods, and agree
that it shall  not  govern  or apply to this  Agreement  or its  performance  or
construction.

13.3  Governing Law
      -------------

This Agreement  shall be governed,  controlled,  interpreted  and defined by and
under the laws of the State of New York and the United States  without regard to
that body of law known as conflicts of law; provided that issues relating to the
validity  and  enforceability  of patents  shall be  governed by the laws of the
jurisdiction by which such patent was granted.

                                   ARTICLE 14
                                     NOTICES

14.1  Notice.
      -------

Any notice required or permitted by this Agreement shall be in writing and shall
be sent by prepaid  registered or certified mail, return receipt  requested;  by
facsimile;  by internationally  recognized courier; or by personal delivery,  in
each case  addressed  to the other Party at the  address  below or at such other
address for which such Party gives notice under this Agreement.

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                                                                         Page 24
<PAGE>

If to the Customer at:

      Stiefel Laboratories, Inc.
      Attention: President and Chief Executive Officer
      255 Alhambre Circle
      Coral Gables, Florida, USA  33134

If to INyX, at:

      INyX Pharma Ltd.
      Attention: Steve Handley
      6 Seymour Court, Manor Park
      Runcorn, Cheshire, UK  WA7 1S&

Such notice shall be deemed to have been given when delivered or, if delivery is
not accomplished by some fault of the addressee, when tendered. Either Party may
change its address for notice by delivering a written  notice of the new address
in accordance with this Article.

                                   ARTICLE 15
                             NATURE OF RELATIONSHIP
                             ----------------------

15.1  No Agency; Independent Contractor
      ---------------------------------

Each Party is and shall be  considered  to be an  independent  contractor of the
other Party. Neither Party shall be the legal agent of the other for any purpose
whatsoever  and neither  Party has any right or authority to make or  underwrite
any promise, warranty or representation, to execute any contract or otherwise to
assume any obligation or responsibility in the name of or on behalf of the other
Party.  Neither  Party shall be bound by or liable to any third  persons for any
act or for any obligation or debt incurred by the other toward such third party,
except to the  extent  specifically  agreed to in  writing by the Party so to be
bound.

15.2  Public Statements
      -----------------

The  Parties  shall   endeavor  to  provide   courtesy   copies  of  any  public
announcements  concerning the  relationship  created by this Agreement.  Neither
Party  shall make any  representations  concerning  the other  without the prior
consent from the other Party. Notwithstanding the foregoing, each Party consents
to  references  to it in  reports  or  documents  or other  disclosures  sent to
stockholders or filed with or submitted to any  governmental  authority or stock
exchange.  Except for such  disclosure as is required by  applicable  law and/or
stock  exchange  regulation,  neither  Party shall make any  announcement,  news
release, public statement, publication or presentation relating to the existence
of this  Agreement or the  arrangements  referred to in this  Agreement  without
first notifying the other Party.

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<PAGE>

                                  ARTICLE 16
                              ADDITIONAL PROVISIONS
                              ---------------------

16.1  Headings
      --------

Article and section  headings  contained  in this  Agreement  are  included  for
convenience  of  reference  only and shall not affect in any way the  meaning or
interpretation of this Agreement.

16.2  Partial Invalidity
      ------------------

If  any  provision  of  this  Agreement  is  held  to be  invalid,  illegal,  or
unenforceable  by a court of competent  jurisdiction,  then:  (a) such provision
will be deemed amended to conform to applicable laws of such  jurisdiction so as
to be valid and enforceable,  or, if it cannot be so amended without  materially
altering the  intention of the Parties,  it will be stricken;  (b) the validity,
legality and enforceability of such provision will not in any way be affected or
impaired thereby in any other jurisdiction;  and (c) the remaining provisions of
this Agreement will remain in full force and effect.

16.3  Survival
      --------

The  covenants and  agreements  set forth in Articles 7, 11 and 13 shall survive
any  termination  or expiration  of this  Agreement and remain in full force and
effect regardless of the cause of termination.

16.4  Entire Agreement
      ----------------

This  Agreement,   including  the  attached  Exhibits,  constitutes  the  entire
agreement of the Parties with respect to the subject matter,  and supersedes all
prior or contemporaneous  understandings or agreements, whether written or oral,
between  the  Customer  and  INyX  with  respect  to  such  subject  matter.  In
particular,  (a) in the event of conflict  between this  Agreement and the terms
and  conditions of any purchase  order or other form generated in performance of
this  Agreement,  then the terms and conditions of this Agreement shall control,
and (b) in the  event  of  conflict  between  this  Agreement  and  the  Quality
Agreement (as it may be amended from time to time),  the terms of this Agreement
shall govern all aspects of the relationship between the Parties except that the
Quality Agreement shall govern with respect to quality matters.

16.5  Waivers
      -------

No waiver of any term or condition of this  Agreement  shall be valid or binding
on either Party unless agreed in writing by the Party to be charged. The failure
of either Party to enforce at any time, or for any period of time, any provision
of this  Agreement,  or the  failure to require at any time  performance  by the
other Party of any provision of this Agreement,  shall in no way be construed to
be a present or future  waiver of such  provisions or of the right of such Party
thereafter to enforce that provision or other provisions of this Agreement.

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<PAGE>

16.6  Assignment, Binding Effect
      --------------------------

Neither  Party shall assign this  Agreement,  by operation of law or  otherwise,
except to an Affiliate of such Party,  without the prior written  consent of the
other Party,  which consent  shall not be  unreasonably  withheld,  and any such
attempted  assignment without such consent shall be void. No assignment shall be
effective until the assignee shall have  unconditionally  assumed in writing all
of the assignor's  obligations under this Agreement and a written notice of such
assignment is given to all the other  Parties.  When duly assigned in accordance
with the  foregoing,  this  Agreement  shall be  binding  upon and  inure to the
benefit of the assignee.

16.7  Amendment
      ---------

No amendment or  modification  of this Agreement  shall be valid or binding upon
the  Parties  unless  made  in  writing  and  signed  by  the  duly   authorized
representatives of both Parties.

16.8  Taxes
      -----

INyX and the  Customer  shall  cooperate  in  seeking  and/or  applying  for all
available waivers, exclusions,  exemptions, rebates and the like with respect to
potential taxes (e.g., VAT) on the Products.

16.9  Conflicting Terms and Conditions
      --------------------------------

All sales  under  this  Agreement  shall be subject  to the  provisions  of this
Agreement (including,  without limitation, the Product Specifications) and shall
not be subject to the terms and  conditions  contained on any purchase  order of
the Customer or confirmation of INyX,  except insofar as any such purchase order
or confirmation establishes:

      (a)   the quantity and form of any Product ordered;

      (b)   the shipment date;

      (c)   the shipment routes and destinations; or

      (d)   the carrier.

16.10 Binding Effect and Assignment
      -----------------------------

Each Party agrees that its rights and  obligations  under this Agreement may not
be transferred or assigned directly or indirectly, except as follows: (a) either
Party may transfer or assign this  Agreement to an Affiliate of such Party which
agrees in writing to undertake the obligations under this Agreement,  (b) either
Party may transfer or assign this  Agreement in connection  with the sale of all
or substantially all of the assigning  Party's related business,  and (c) either
Party may transfer or assign this Agreement to a non-Affiliate  third party with

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<PAGE>

the  prior  written  consent  of the other  Party,  which  consent  shall not be
unreasonably withheld. Subject to the foregoing, this Agreement shall be binding
upon and inure to, the benefit of the Parties, their successors and assigns. Any
attempted  assignment  contrary to the provisions of this Section 16.10 shall be
deemed  ineffective,  and either  Party shall have the right to  terminate  this
Agreement, with the effect described in Section 10.2.

16.11 Counterparts
      ------------

This Agreement may be executed in two or more counterparts,  each of which shall
be deemed an original and all of which  together  shall  constitute  one and the
same agreement.

IN WITNESS  WHEREOF,  the Parties have caused this Agreement to be duly executed
by their respective duly authorized officers as of the date first written above.

STIEFEL LABORATORIES, INC.               INYX PHARMA LTD.

Per: /S/ Tessie L. Brunker               Per: /S/ Steven Handley
     ------------------------                 ---------------------
     Name:  Tessie L. Brunker                 Name:  Steven Handley
     Title: Vice President,                   Title: Director
            CFO and Treasurer

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<PAGE>

                                LIST OF EXHIBITS

Exhibit 4.3(a)          Current Customers and Dermatological Products

Exhibit A               Stiefel Products

Exhibit B               Pricing

Exhibit C               Quality Agreement

Exhibit D               Forecasts

Exhibit E-1, E-2 etc    Development Agreements

                                 Exhibit 4.3(a)

                  Current Customers and Dermatological Products
                  ---------------------------------------------

See Attachment dated 28th February, 2003

                                    Exhibit A

                                Stiefel Products
                                ----------------

Marketed Name           NDC Code                Size

                                    Exhibit B

                                     Pricing
                                     -------

Name  Size              Price per Unit*         Price per Unit(Free Issue)

* * *

                                    Exhibit C

                                Quality Agreement
                                -----------------

[See Attachment dated 4.03.03]

                                    Exhibit D

                           Forecast Format and Timing
                           --------------------------

With respect to forecasts supplied by the Customer:

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                                                                        Exhibits
<PAGE>

Date Submitted              Description                Purchase   Orders  Issued
                                                       for  Manufacturing  Dates
                                                       During:

                                   Exhibit E

                             Development Agreements

Future  development  agreements  between the Parties with respect to new Product
candidates shall be attached to this Agreement as Exhibits E-1, E-2, E-3, etc.

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                                                                        Exhibits

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