Document:

Exhibit 10(b)

  

  

  POWER OF ATTORNEY

  

  

  We, the undersigned directors and/or officers of The Lincoln National Life Insurance Company, hereby constitute and appoint Delson R. Campbell, Scott C. Durocher, Kimberly A. Genovese, Daniel P. Herr, Donald E. Keller, Michelle Grindle,  Jeffrey L. Smith, Jassmin McIver-Jones, Carolyn Augur and John D. Weber,  individually, our true and lawful
    attorneys-in-fact, with full power to each of them to sign for us, in our names and in the capacities indicated below, any Registration Statements and any and all amendments to Registration Statements; including exhibits, or other documents filed on
    Forms N-6, N-4 or S-3 or any successors or amendments to these Forms, filed with the Securities and Exchange Commission, under the Securities Act of 1933 and/or Securities Act of 1940, on behalf of the Company in its own name or in the name of one of
    its Separate Accounts, hereby ratifying and confirming our signatures as they may be signed by any of our attorneys-in-fact to any such amendments to said Registration Statements as follows:

  

  

  Variable Life Insurance Separate Accounts:

  

  

  
    
      

  

  	
          Account

        	
          Product name

        
	
          Lincoln Life Flexible Premium Variable Life Account D (811-04592)

        	
          Variable Universal Life Leadership Series

        
	
          Lincoln Life Flexible Premium Variable Life Account F (811-05164)

        	
          American Legacy Life

          American Legacy Estate Builder

        
	
          Lincoln Life Flexible Premium Variable Life Account G (811-05585)

        	
          VUL-III

        
	
          Lincoln Life Flexible Premium Variable Life Account J (811-08410)

        	
          American Legacy Variable Life

        
	
          Lincoln Life Flexible Premium Variable Life Account K (811-08412)

        	
          Multi Fund Variable Life

        
	
          Lincoln Life Flexible Premium Variable Life Account M (811-08557)

        	
          VULdb / VULdb ES

          VULdb-II ES

          VUL-I / VULcv

          VULcv-II / VULcvII ES / VUL Flex

          VULcv-III ES

          MoneyGuard VUL

          VULone ES / VULone 2005 ES

          Momentum VULone / Momentum VULone 2005

          VULcv-IV ES

          VULdb-IV ES

          Momentum VULone 2007

          VULone 2007

          AssetEdge VUL

          AssetEdge VUL2015/AssetEdge Exec VUL 2015

          VULone2012

          VULone2014

          InReach VULone2014

          VULone2019

          AssetEdge VUL2019/AssetEdge Exec VUL 2019

          AssetEdge VUL2019-2/AssetEdge Exec VUL 2019-2

          AssetEdge VUL2020/AssetEdge Exec VUL 2020

        
	
          Lincoln Life Flexible Premium Variable Life Account R (811-08579)

        	
          SVUL / SVUL-I

          SVUL-II / SVUL-II ES

          SVUL-III ES

          SVUL-IV ES / PreservationEdge SVUL

          SVULone ES

          Momentum SVULone

          SVULone 2007 ES

          Momentum SVULone 2007

          SVULone2013

          SVULone2016

          SVULone2019

        
	
          Lincoln Life Flexible Premium Variable Life Account S (811-09241)

        	
          CVUL / CVUL Series III / CVUL Series III ES

          LCV4 ES

          LCV5 ES / LCC VUL

          Lincoln Corporate Executive VUL

        
	
          Lincoln Life Flexible Premium Variable Life Account Y (811-21028)

        	
          American Legacy VULcv-III

          American Legacy VULdb-II

          American Legacy SVUL-II

          American Legacy SVUL-III

          American Legacy VULcv-IV

          American Legacy VULdb-IV

          American Legacy SVUL-IV/PreservationEdge SVUL

          American Legacy AssetEdge

        

  

  

  

  

  Variable Annuity Separate Accounts:

  

  

  	
          Account

        	
          Product name

        
	
          Lincoln National Variable Annuity Account C (811-03214)

        	
          Multi-Fund

          Multi-Fund Select

          Multi-Fund 5 Retirement Annuity

        
	
          Lincoln National Variable Annuity Account E (811-04882)

        	
          The American Legacy

        
	
          Lincoln National Variable Annuity Account H (811-05721)

        	
          American Legacy II

          American Legacy III

          American Legacy III B Class

          American Legacy III C Share

          American Legacy III Plus

          American Legacy III View

          American Legacy Design

          American Legacy Signature

          American Legacy Fusion

          American Legacy Series

          American Legacy Advisory

          American Legacy Target Date Income B Share

          American Legacy Target Date Income Advisory

          Shareholder’s Advantage

          Shareholder’s Advantage A Class

          Shareholder’s Advantage purchased on and after May 21, 2018

        
	
          Lincoln National Variable Annuity Account L (811-07645)

        	
          Group Variable Annuity

          Secured Retirement Income Version 1

          Secured Retirement Income Version 2

          Secured Retirement Income Version 3

          Secured Retirement Income Version 4

          Retirement Income Rollover Version 1

          Retirement Income Rollover Version 2

          Retirement Income Rollover Version 3

          Retirement Income Rollover Version 4

        
	 	 
	
          Lincoln Life Variable Annuity Account N (811-08517)

        	
          ChoicePlus Assurance (A Share)

          ChoicePlus Assurance (A Class)

          ChoicePlus Assurance (B Share)

          ChoicePlus Assurance (B Class)

          ChoicePlus Assurance (C Share)

          ChoicePlus Assurance (L Share)

          ChoicePlus Assurance (Bonus)

          Choice Plus

          Choice Plus II

          ChoicePlus Access

          ChoicePlus II Access

          ChoicePlus Bonus

          ChoicePlus II Bonus

        
	 	
          ChoicePlus II Advance

          ChoicePlus Design

          ChoicePlus Signature

          ChoicePlus Rollover

          ChoicePlus Fusion

          ChoicePlus Series

          ChoicePlus Prime

          ChoicePlus Advisory

          ChoicePlus Select B-Share

          InvestmentSolutions

          InvestmentSolutions RIA

          Lincoln Investor Advantage

          Lincoln Invester Advantage 2018

          Lincoln Investor Advantage Fee-Based

          Lincoln Investor Advantage RIA

          Lincoln Investor Advantage Advisory

          Lincoln Investor Advantage RIA Class

          Lincoln Investor Advantage Advisory Choice

          Lincoln Level Advantage B Share Indexed Variable Annuity

          Lincoln Level Advantage Advisory Indexed Variable Annuity

          Lincoln Level Advantage B Class Indexed Variable Annuity

          Lincoln Level Advantage Advisory Class Indexed Variable Annuity

          Lincoln Level Advantage Fee-Based Indexed Variable Annuity

          Lincoln Level Advantage Select B-Share Indexed Variable Annuity

          Lincoln Level Advantage Design B-Share Indexed Variable Annuity

          Lincoln Level Advantage Design Advisory Indexed Variable Annuity

          Core Income

        
	
          Lincoln Life Variable Annuity Account Q (811-08569)

        	
          Multi-Fund Group

        
	
          Lincoln Life S-3 Filing

        	
          Lincoln Level Advantage B Share Indexed Variable Annuity

          Lincoln Level Advantage Advisory Indexed Variable Annuity

          Lincoln Level Advantage B Class Indexed Variable Annuity

          Lincoln Level Advantage Advisory Class Indexed Variable Annuity

          Lincoln Level Advantage Fee-Based Indexed Variable Annuity

          Lincoln Level Advantage Select B Share Indexed Variable Annuity

          Lincoln Level Advantage Design B-Share Indexed Variable Annuity

          Lincoln Level Advantage Design Advisory Indexed Variable Annuity

        

  

  

  

  

  Except as otherwise specifically provided herein, the power-of-attorney granted herein shall not in any manner revoke in whole or in part any power-of-attorney that
    each person whose signature appears below has previously executed.  This power-of-attorney shall not be revoked by any subsequent power-of-attorney each person whose signature appears below may execute, unless such subsequent power specifically refers
    to this power-of-attorney or specifically states that the instrument is intended to revoke all prior general powers-of-attorney or all prior powers-of-attorney.

  

  

  This Power-of-Attorney may be executed in separate counterparts each of which when executed and delivered shall be an original; but all such counterparts shall
    together constitute one and the same instrument.  Each counterpart may consist of a number of copies, each signed by less than all, but together signed by all, of the undersigned.

  

  

  

  

  

  

  Signature                                                                                    Title

  

  

  /s/Dennis R. Glass

  	______________________________	
          President, Chairman and Director

        

  Dennis R. Glass

  

  

  /s/Ellen G. Cooper

  	_____________________________	
          Executive Vice President, Chief Investment Officer

        

  Ellen G. Cooper                                                                                                  and Director

  

  

  /s/Randal J. Freitag

  	_____________________________	
          Executive Vice President; Chief Financial Officer and Director

        

  Randal J. Freitag

  

  

  /s/Christine A. Janofsky

  	_____________________________	
          Senior Vice President and Controller

        

  Christine A. Janofsky

  

  

  /s/Leon E. Roday

  	_____________________________	
          Executive Vice President, General Counsel and Director

        

  Leon E. Roday

  

  

  /s/Wilford H. Fuller

  	_____________________________	
          Executive Vice President and Director

        

  Wilford H. Fuller

  

  

  /s/Keith J. Ryan

  ______________________________                                       
    Vice President and Director

  Keith J. Ryan

  

  

  

  

  We, Delson R. Campbell, Scott C. Durocher, Kimberly A. Genovese, Daniel P. Herr, Donald E. Keller, Michelle Grindle, Jeffrey L. Smith, Jassmin McIver-Jones,
    Carolyn Augur and John D. Weber, have read the foregoing Power of Attorney.  We are the person(s) identified therein as agent(s) for the principal named therein.  We acknowledge our legal responsibilities.

  

  

  	
          /s/Delson R. Campbell                                                      

          Delson R. Campbell

           

        	
          /s/Scott C. Durocher  

          Scott C. Durocher

        
	
          /s/Kimberly A. Genovese                                                      

          Kimberly A. Genovese

           

        	
          /s/Daniel P. Herr                                                      

          Daniel P. Herr

        
	
          /s/Donald E. Keller                                                      

          Donald E. Keller

           

        	
          /s/Michelle Grindle                                                      

          Michelle Grindle

        
	
          /s/Jeffrey L. Smith                                                      

          Jeffrey L. Smith

           

        	
          /s/John D. Weber                                                      

          John D. Weber

        
	
          /s/Jassmin McIver-Jones                                                      

          Jassmin McIver-Jones

        	
          /s/Carolyn Augur                                                      

          Carolyn Augur

        

  

  

  

  

  

  

  

  

  

  

  Version dated: 5/2020EX-10.1

 Exhibit 10.1 

Execution Copy 

COLLABORATION AND LICENSE AGREEMENT 

by and between 
 WYETH 

acting through its Wyeth Pharmaceuticals Division 

and 
 TRUBION PHARMACEUTICALS,
INC. 
 December 19, 2005 

 TABLE OF CONTENTS 

 

													
	 	 	 	 	  	 	  	 	  	Page	 
	 1.
	 	 	DEFINITIONS	  		  	 	1	 
			
	 2.
	 	 	LICENSES	  	 	17	 
		 	 	2.1	 	  	Licenses to Wyeth	  	 	17	 
		 				  	2.1.1	  	Exclusive Licenses	  	 	17	 
		 				  	2.1.2	  	Retained Rights of Trubion	  	 	17	 
		 	 	2.2	 	  	License to Trubion	  	 	17	 
		 	 	2.3	 	  	Exclusivity	  	 	18	 
		 				  	2.3.1	  	CD20 Product Exclusivity	  	 	18	 
		 				  	2.3.2	  	HER2 Product Exclusivity	  	 	18	 
		 				  	2.3.3	  	Limitations	  	 	19	 
		 	 	2.4	 	  	Sublicensing	  	 	19	 
		 	 	2.5	 	  	Direct Licenses to Affiliates	  	 	20	 
		 	 	2.6	 	  	Right of Reference	  	 	20	 
		 	 	2.7	 	  	Section 365(n) of Bankruptcy Code	  	 	20	 
		 	 	2.8	 	  	No Implied Rights	  	 	21	 
			
	 3.
	 	 	RESEARCH PROGRAM	  	 	22	 
		 	 	3.1	 	  	Scope and Conduct of the Research Program	  	 	22	 
		 	 	3.2	 	  	Designation of Targets	  	 	22	 
		 				  	3.2.1	  	Target Candidates	  	 	22	 
		 				  	3.2.2	  	Released Targets	  	 	24	 
		 				  	3.2.3	  	Wyeth Targets	  	 	24	 
		 				  	3.2.4	  	Excluded Targets	  	 	26	 
		 	 	3.3	 	  	Term and Termination of the Research Program	  	 	28	 
		 				  	3.3.1	  	Research Term	  	 	28	 
		 				  	3.3.2	  	Termination of Research Program by Wyeth	  	 	28	 
		 	 	3.4	 	  	Joint Research Committee	  	 	29	 
		 				  	3.4.1	  	Composition	  	 	29	 
		 				  	3.4.2	  	Responsibilities	  	 	29	 
		 				  	3.4.3	  	Meetings	  	 	29	 
		 				  	3.4.4	  	Voting	  	 	29	 
		 				  	3.4.5	  	Dispute Resolution	  	 	29	 
		 				  	3.4.6	  	Minutes	  	 	30	 
		 	 	3.5	 	  	Research Plan	  	 	30	 
		 	 	3.6	 	  	Funding of the Research Program	  	 	30	 
		 				  	3.6.1	  	Research Funding	  	 	30	 
		 				  	3.6.2	  	Reimbursement Payments	  	 	31	 
		 				  	3.6.3	  	Records and Audits	  	 	32	 
		 	 	3.7	 	  	Data and Deliverables	  	 	33	 
		 	 	3.8	 	  	Alliance Managers	  	 	33	 
			
	 4.
	 	 	 PRODUCT DEVELOPMENT, MANUFACTURING, COMMERCIALIZATION AND REGULATORY
MATTERS
	  	 	34	 
		 	 	4.1	 	  	Product Development	  	 	34	 
		 	 	4.2	 	  	Transfer of Product Data and Filings	  	 	34	 
		 	 	4.3	 	  	Regulatory Approvals	  	 	35	 
		 	 	4.4	 	  	Regulatory Reporting	  	 	35	 
		 	 	4.5	 	  	Progress Reports	  	 	35	 
		 	 	4.6	 	  	CD20 Product Development	  	 	36	 
		 	 	4.7	 	  	Joint Development Committee	  	 	37	 

  
 i 

															
		 	 	4.8	 	  	 	Joint Project Team; Development Plan	  	 	38	 
		 	 	4.9	 	  	 	Manufacturing	  	 	38	 
		 	 	4.10	 	  	 	Commercialization	  	 	39	 
		 	 	4.11	 	  	 	Co-Promotion Option	  	 	39	 
		 	 	4.12	 	  	 	Co-Promotion Committee	  	 	40	 
		 	 	4.13	 	  	 	Co-Branding	  	 	40	 
		 	 	4.14	 	  	 	Marking	 	  		  	 	40	 
			
	 5.
	 	 	CONSIDERATION	  	 	40	 
		 	 	5.1	 	  	 	Initial Research and Development Expense Payment	  	 	40	 
		 	 	5.2	 	  	 	Equity	  	 	40	 
		 	 	5.3	 	  	 	Additional Research and Development Expense Payments	  	 	41	 
		 	 	5.4	 	  	 	Royalties	  	 	41	 
		 				  	 	5.4.1	 	  	Product Royalties	  	 	41	 
		 				  	 	5.4.2	 	  	CD20 Product Royalties	  	 	41	 
		 				  	 	5.4.3	 	  	HER2 Product Royalties	  	 	44	 
		 				  	 	5.4.4	 	  	Other Product Royalties	  	 	47	 
		 				  	 	5.4.5	 	  	Expiration of Royalty Period	  	 	48	 
		 				  	 	5.4.6	 	  	Royalty Adjustments	  	 	48	 
		 	 	5.5	 	  	 	Reports and Payments	  	 	49	 
		 				  	 	5.5.1	 	  	Cumulative Royalties	  	 	49	 
		 				  	 	5.5.2	 	  	Royalty Statements and Payments	  	 	50	 
		 				  	 	5.5.3	 	  	Taxes and Withholding	  	 	50	 
		 				  	 	5.5.4	 	  	Currency	  	 	50	 
		 				  	 	5.5.5	 	  	Additional Provisions Relating to Royalties	  	 	51	 
		 				  	 	5.5.6	 	  	Interest on Past Due Payments	  	 	51	 
		 	 	5.6	 	  	 	Maintenance of Records; Audits	  	 	51	 
		 				  	 	5.6.1	 	  	Record Keeping	  	 	51	 
		 				  	 	5.6.2	 	  	Audits	  	 	51	 
		 				  	 	5.6.3	 	  	Underpayments/Overpayments	  	 	52	 
		 				  	 	5.6.4	 	  	Confidentiality	  	 	52	 
			
	 6.
	 	 	INTELLECTUAL PROPERTY	  	 	52	 
		 	 	6.1	 	  	 	Inventions; Joint Patent Committee	  	 	52	 
		 				  	 	6.1.1	 	  	Ownership and Inventorship	  	 	53	 
		 				  	 	6.1.2	 	  	SMIP Improvements	  	 	53	 
		 				  	 	6.1.3	 	  	Joint Patent Committee	  	 	54	 
		 	 	6.2	 	  	 	Patent Rights	  	 	55	 
		 				  	 	6.2.1	 	  	Filing, Prosecution and Maintenance of Patent Rights	  	 	55	 
		 				  	 	6.2.2	 	  	Enforcement of Patent Rights	  	 	62	 
		 				  	 	6.2.3	 	  	Infringement and Third Party Licenses	  	 	65	 
		 				  	 	6.2.4	 	  	Patent Certifications	  	 	67	 
		 				  	 	6.2.5	 	  	Patent Term Restoration	  	 	68	 
		 	 	6.3	 	  	 	Trademarks	  	 	68	 
			
	 7.
	 	 	CONFIDENTIALITY	  	 	68	 
		 	 	7.1	 	  	 	Confidentiality	  	 	68	 
		 	 	7.2	 	  	 	Authorized Disclosure and Use	  	 	69	 
		 				  	 	7.2.1	 	  	Disclosure	  	 	69	 
		 				  	 	7.2.2	 	  	Use	  	 	70	 
		 	 	7.3	 	  	 	SEC Filings	  	 	70	 
		 	 	7.4	 	  	 	Public Announcements; Publications	  	 	70	 
		 				  	 	7.4.1	 	  	Coordination	  	 	70	 
		 				  	 	7.4.2	 	  	Announcements	  	 	70	 
		 				  	 	7.4.3	 	  	Publications	  	 	71	 

  
 ii 

											
	 8.
	 	REPRESENTATIONS AND WARRANTIES	  	 	71	 
		 	8.1	  	Representations and Warranties of Each Party	  	 	71	 
		 	8.2	  	Additional Representations and Warranties of Trubion	  	 	72	 
		 	8.3	  	Mutual Covenant	  	 	74	 
		 	8.4	  	Additional Covenants of Trubion	  	 	74	 
		 	8.5	  	Representation by Legal Counsel	  	 	74	 
		 	8.6	  	No Inconsistent Agreements	  	 	74	 
		 	8.7	  	Disclaimer	  	 	74	 
			
	 9.
	 	GOVERNMENT APPROVALS; TERM AND TERMINATION	  	 	74	 
		 	9.1	  	HSR Filing	  	 	74	 
		 	9.2	  	Other Government Approvals	  	 	75	 
		 	9.3	  	Term	  	 	75	 
		 	9.4	  	Termination Upon HSR Denial	  	 	75	 
		 	9.5	  	Material Breach	  	 	75	 
		 	9.6	  	Termination by Wyeth	  	 	76	 
		 		  	9.6.1	  	Termination Without Cause	  	 	76	 
		 		  	9.6.2	  	Termination for a Material Safety or Regulatory Issue	  	 	76	 
		 	9.7	  	Effects of Termination	  	 	77	 
		 		  	9.7.1	  	Effect of Termination by Wyeth for Cause	  	 	77	 
		 		  	9.7.2	  	Effect of Termination by Trubion for Cause	  	 	81	 
		 		  	9.7.3	  	Effect of Termination by Wyeth Without Cause	  	 	84	 
		 		  	9.7.4	  	Effect of Termination by Wyeth for a Material Safety or Regulatory Issue	  	 	86	 
		 		  	9.7.5	  	Post-Termination Rights to Wyeth Technology and Trubion Technology	  	 	87	 
		 		  	9.7.6	  	Post-Termination Licenses to Wyeth Technology	  	 	87	 
		 		  	9.7.7	  	Post-Termination Transfer of Product Data and Filings and Existing Trademarks	  	 	87	 
		 		  	9.7.8	  	Manufacturing of Licensed Products After Termination	  	 	88	 
		 		  	9.7.9	  	Post-Termination Disposition of Inventories of Licensed Products	  	 	89	 
		 		  	9.7.10	  	Continuation of Rights and Licenses Under Sections 6.1.1 and 6.1.2	  	 	90	 
		 		  	9.7.11	  	Continuation of Other Rights and Obligations	  	 	90	 
		 	9.8	  	Modification of Agreement Terms by Wyeth	  	 	90	 
		 	9.9	  	Survival of Certain Obligations	  	 	91	 
		 	9.10	  	Change of Control	  	 	92	 
		 		  	9.10.1	  	Definition	  	 	92	 
		 		  	9.10.2	  	Change of Control of Wyeth	  	 	93	 
		 		  	9.10.3	  	Change of Control of Trubion	  	 	95	 
			
	 10.
	 	INDEMNIFICATION AND INSURANCE	  	 	95	 
		 	10.1	  	Indemnification by Wyeth	  	 	95	 
		 	10.2	  	Indemnification by Trubion	  	 	95	 
		 	10.3	  	Procedure	  	 	96	 
		 	10.4	  	Insurance	  	 	96	 
			
	 11.
	 	DISPUTE RESOLUTION	  	 	97	 
		 	11.1	  	General	  	 	97	 
		 	11.2	  	Failure of Executive Officers to Resolve Dispute	  	 	97	 
		 	11.3	  	Disclaimer of Consequential and Punitive Damages	  	 	97	 
			
	 12.
	 	MISCELLANEOUS	  	 	97	 
		 	12.1	  	Periodic Executive Meetings	  	 	97	 
		 	12.2	  	Assignment	  	 	98	 
		 	12.3	  	Further Actions	  	 	98	 
		 	12.4	  	Force Majeure	  	 	98	 

  
 iii 

											
	     
	 	12.5	 	Non-Solicitation	  	 	98	 
		 	12.6	 	Correspondence and Notices	  	 	99	 
		 		 	12.6.1	  	Ordinary Notices	  	 	99	 
		 		 	12.6.2	  	Extraordinary Notices	  	 	99	 
		 	12.7	 	Amendment	  	 	100	 
		 	12.8	 	Waiver	  		  	 	100	 
		 	12.9	 	Severability	  	 	100	 
		 	12.10	 	Descriptive Headings	  	 	100	 
		 	12.11	 	Governing Law	  	 	101	 
		 	12.12	 	Entire Agreement of the Parties	  	 	101	 
		 	12.13	 	Independent Contractors	  	 	101	 
		 	12.14	 	Counterparts	  	 	101	 

  
 iv 

 EXHIBITS 

Exhibit 1.122 — TRU-015 

Exhibit 1.129 — Trubion Patent Rights 
 Exhibit 1.132 —
Trubion Third Party Agreements 
 Exhibit 3.2.1 — Trubion’s “Milestone One” 

Exhibit 3.2.4 — Excluded Targets 
 Exhibit 4.4 — Adverse
Event Reporting Procedures 
 Exhibit 5.2A — Stock Purchase Agreement 

Exhibit 5.2B — Amendment to Investor Rights Agreement 

Exhibit 5.3 — Additional Research and Development Expense Payments 

Exhibit 8.2(d) — Third Party Rights 
 Exhibit 8.2(e) —
Government Funding Agreements 

  
 v 

 COLLABORATION AND LICENSE AGREEMENT 

This Collaboration and License Agreement (the “Agreement”) is entered into as of December 19, 2005 (the “Signing
Date”), by and between Wyeth, together with its Affiliates (as defined below), acting through its Wyeth Pharmaceuticals Division, a corporation organized and existing under the laws of the State of Delaware and having a place of business at 500
Arcola Road, Collegeville, Pennsylvania 19426 (collectively, “Wyeth”) and Trubion Pharmaceuticals, Inc., together with its Affiliates (as defined below), a corporation organized and existing under the laws of the State of Delaware and
having a principal place of business at 2401 4th Avenue, Suite 1050, Seattle, Washington 98121 (collectively, “Trubion”). Wyeth and Trubion may each be referred to herein individually as a “Party” and collectively as the
“Parties”. 
 WHEREAS, Wyeth is engaged in the research, development and commercialization of pharmaceutical and health care
products; 
 WHEREAS, as of the Signing Date, Trubion has developed certain SMIPs (as defined below) and CD20 Products (as defined below),
as well as certain Patent Rights (as defined below) and Know-How (as defined below) pertaining to Trubion’s SMIP technology platform; 

WHEREAS, Wyeth and Trubion desire to collaborate to discover, research and develop, and Wyeth desires to research, develop, manufacture and
commercialize, Licensed Products (as defined below) as provided herein; and 
 WHEREAS, Wyeth desires to obtain from Trubion, and Trubion
desires to grant to Wyeth, certain exclusive rights so that Wyeth may develop, manufacture and commercialize such Licensed Products, as provided herein. 

NOW THEREFORE, in consideration of the mutual promises and covenants set forth below and other good and valuable consideration, the receipt
and sufficiency of which is hereby acknowledged, the Parties hereby agree as follows: 
  

	1.	 DEFINITIONS. 

  

	 	1.1.	 “Additional Research and Development Expense Payment” shall have the meaning set forth in
Section 5.3 hereof. 

  

	 	1.2.	 “Additional Third Party Licenses” shall have the meaning set forth in Section 6.2.3(a)
hereof. 

  

	 	1.3.	 “Affiliate(s)” shall mean, with respect to any Person, any other Person which controls, is
controlled by or is under common control with such Person. A Person shall be regarded as in control of another entity if it owns or controls at least fifty percent (50%) of the equity securities of the subject entity entitled to vote in the election
of directors (or, in the case of an entity that is not a corporation, for the election of the corresponding managing 

	 	authority); provided, however, that the term “Affiliate” shall not include subsidiaries or other entities in which a Party or its Affiliates owns a majority of the ordinary voting power necessary to
elect a majority of the board of directors or other governing board, but is restricted from electing such majority by contract or otherwise, until such time as such restrictions are no longer in effect. 

 

	 	1.4.	 “Agreement” shall have the meaning set forth in the preamble hereof. 

 

	 	1.5.	 “Bankruptcy Code” shall have the meaning set forth in Section 2.7 hereof.

  

	 	1.6.	 “BLA” shall have the meaning set forth in Section 1.100 hereof. 

 

	 	1.7.	 “Calendar Quarter” shall mean the respective periods of three (3) consecutive calendar
months ending on March 31, June 30, September 30 or December 31, for so long as this Agreement is in effect. 

  

	 	1.8.	 “Category 1 Covered SMIP Improvement” shall have the meaning set forth in
Section 6.1.3(b) hereof. 

  

	 	1.9.	 “Category 2 Covered SMIP Improvement” shall have the meaning set forth in
Section 6.1.3(b) hereof. 

  

	 	1.10.	 “CD20 Antigen” shall mean the human protein antigen that is known as CD20, and identified as a
full length CD20 protein antigen in GenBank, and identified by GenBank Accession Nos. NP_690605, NP_068769 or P11836, and any other protein that Has The Same Sequence as the foregoing. 

 

	 	1.11.	 “CD20 Effective Royalty Rate” shall have the meaning set forth in Section 5.4.2(a)
hereof. 

  

	 	1.12.	 “CD20 Product” shall mean any TRU-015 Product and/or Follow-On CD20 Product (as the context requires). 

  

	 	1.13.	 “Cell Lines” shall mean the cell lines and any other expression systems that produce or
express any SMIP. 

  

	 	1.14.	 “Change of Control” shall have the meaning set forth in Section 9.10.1 hereof.

  

	 	1.15.	 “Clinical Study Supplies” shall have the meaning set forth in Section 4.9 hereof.

  

	 	1.16.	 “Combination Product” shall mean any product containing as active ingredients both (a) a
Product and (b) one or more other pharmaceutically active compounds or substances. 

  
 2 

	 	1.17.	 “Combination Sale” shall have the meaning set forth in Section 1.76 hereof.

  

	 	1.18.	 “Commercialization” or “Commercialize” shall mean activities directed to marketing,
promoting, distributing, importing or selling a product. Commercialization shall not include any activities related to Manufacturing or Development. 

  

	 	1.19.	 “Commercially Reasonable Efforts” shall mean, with respect to the efforts to be expended by
any Party with respect to any objective, those reasonable, diligent, good faith efforts to accomplish such objective as such Party would normally use to accomplish a similar objective under similar circumstances. With respect to any objective
relating to the Development and/or Commercialization of a Licensed Product by any Party, “Commercially Reasonable Efforts” shall mean those efforts and resources normally used by such Party with respect to a product owned or controlled by
such Party, or to which such Party has similar rights, which product is of similar market potential and is at a similar stage in its development or life as is such Licensed Product, taking into account issues of safety, efficacy, product profile,
the competitiveness of the marketplace, the proprietary position of the Licensed Product, the regulatory structure involved, profitability of the Licensed Product and other relevant commercial factors. A “Commercially Reasonable”
action or decision of a Party refers in this Agreement to an action or decision taken or made by such Party using its Commercially Reasonable Efforts. 

  

	 	1.20.	 “Confidential Information” of a Party shall mean all
Know-How or other information, including, without limitation, proprietary information and materials (whether or not patentable) regarding such Party’s technology, products, business information or
objectives, that is communicated in any way or form by the Disclosing Party to the Receiving Party, either prior to or after the Effective Date of this Agreement, and whether or not such Know-How or other
information is identified as confidential at the time of disclosure; provided that, information not identified as confidential by the Disclosing Party shall be deemed to be Confidential Information of the Disclosing Party if the Receiving
Party knows, or should have had a reasonable expectation, that the information communicated by the Disclosing Party is Confidential Information of the Disclosing Party. The terms and conditions of this Agreement shall be considered Confidential
Information of both Parties. 

  

	 	1.21.	 “Conjugate(s)” shall mean SMIP(s) fused genetically or linked, either directly or through a
linker molecule, with any biological, cytostatic, cytotoxic or radioactive agent. 

  
 3 

	 	1.22.	 “Control” or “Controlled” shall mean with respect to any (a) item of
information, including, without limitation, Know-How, or (b) intellectual property right, the possession (whether by ownership or license, other than pursuant to this Agreement) by a Party of the ability
to grant to the other Party a license or to extend other rights as provided herein, under such item or right without violating the terms of any agreement or other arrangements with any Third Party. 

 

	 	1.23.	 “Co-Promotion” shall mean the joint promotion of a
CD20 Product in the United States by both Parties and/or their respective Affiliates under the same CD20 Product Trademark(s). “Co-Promote,” when used as a verb, shall mean to engage in such Co-Promotion. 

  

	 	1.24.	 “Co-Promotion Period” shall have the meaning set forth
in Section 4.11 hereof. 

  

	 	1.25.	 “Covered SMIP Improvement” shall have the meaning set forth in Section 6.1.2 hereof.

  

	 	1.26.	 “Deposited Protein” shall have the meaning set forth in Section 1.45 hereof.

  

	 	1.27.	 “Designated Target(s)” shall have the meaning set forth in Section 9.8 hereof.

  

	 	1.28.	 “Development” or “Develop” shall mean
non-clinical and clinical drug development activities pertaining to a product, including, without limitation, toxicology, pharmacology, test method development and stability testing, process development,
formulation development, delivery system development, quality assurance and quality control development, statistical analysis, clinical studies (including pre- and post-approval studies), regulatory affairs,
pharmacovigilance and Regulatory Approval and clinical study regulatory activities (including regulatory activities directed to obtaining pricing and reimbursement approvals). 

 

	 	1.29.	 “Development Plan” shall mean the written plan for the Development of CD20 Products described
in Section 4.8 hereof. 

  

	 	1.30.	 “Disclosing Party” shall have the meaning set forth in Section 7.1 hereof.

  

	 	1.31.	 “Effective Date” shall mean the later to occur of (a) the Signing Date and (b) the HSR
Clearance Date. 

  

	 	1.32.	 “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended.

  

	 	1.33.	 “Excluded Target(s)” shall mean the Target(s) described in Section 3.2.4 hereof as
Excluded Target(s). 

  
 4 

	 	1.34.	 “Exclusivity Covenants” shall have the meaning set forth in Section 9.10.2(c) hereof.

  

	 	1.35.	 “Executive Officers” shall mean the President of Wyeth Pharmaceuticals (or an executive
officer of Wyeth designated by such President of Wyeth Pharmaceuticals) and the Chief Executive Officer of Trubion (or an executive officer of Trubion designated by such Chief Executive Officer). 

 

	 	1.36.	 “Exercise Notice” shall have the meaning set forth in Section 9.10.2(c) hereof.

  

	 	1.37.	 “Existing Activities” shall have the meaning set forth in Section 9.10.2(c) hereof.

  

	 	1.38.	 “Existing Trademarks” shall have the meaning set forth in Section 9.7.1(a).

  

	 	1.39.	 “FDA” shall mean the United States Food and Drug Administration or any successor agency
thereto. 

  

	 	1.40.	 “FD&C Act” shall mean the United States Federal Food, Drug, and Cosmetic Act (21 U.S.C.
§ 301 et seq.), as amended, and the rules and regulations promulgated thereunder. 

  

	 	1.41.	 “First Commercial Sale” shall mean, with respect to a given Licensed Product and any country
in the Territory, the first sale or transfer for value of such Licensed Product under this Agreement by Wyeth or its sublicensees to a Third Party in such country following receipt of marketing authorization from the appropriate Regulatory Authority
permitting commercial sale of such Licensed Product in such country. 

  

	 	1.42.	 “Follow-On CD20 Product” shall mean any product
containing a Follow-On CD20 SMIP. 

  

	 	1.43.	 “Follow-On CD20 SMIP” shall mean any SMIP (other than TRU-015) directed against the CD20 Antigen or a portion thereof. 

  

	 	1.44.	 “FTE” shall mean a full time equivalent scientific person (M.S. or Ph.D. level) year,
consisting of a minimum of a total of one thousand eight hundred eighty (1,880) hours per year of scientific work by an employee of Trubion on or directly related to and in support of the Research Program. Work on or directly related to the Research
Program can include, but is not limited to, experimental preclinical laboratory and research work, recording and writing up results, reviewing literature and references, holding scientific discussions, managing and leading scientific staff and
carrying out management duties, in each case where such activities are directly related to the Research Program. 

  
 5 

	 	1.45.	 “Has The Same Sequence” shall mean, with respect to a specific protein (as described by an
amino acid sequence identified by a GenBank accession number; a “New Protein”), that another specific protein (as described by an amino acid sequence identified by a GenBank accession number; each, a “Deposited Protein”) has at
least ninety percent (90%) amino acid sequence identity over at least ninety percent (90%) of the length of the New Protein. 

By way of example only, if the New Protein consists of 100 amino acids, and any contiguous sequence of 90 amino acids contained in the
Deposited Protein has at least 90% sequence identity to any contiguous sequence of 90 amino acids in the New Protein (that is, at least 81 of the 90 contiguous amino acids in such Deposited Protein sequence are identical to any 81 of any 90
contiguous amino acids in such New Protein), then the New Protein Has The Same Sequence as the Deposited Protein. 
  

	 	1.46.	 “HER2 Antigen” shall mean the human protein antigen that is known as human epidermal growth
factor receptor (also known as c-erb-B2 or HER2/neu), and identified as a full length human epidermal growth factor receptor in GenBank and identified by GenBank
Accession Nos. NP_004439.2, NP_001005862 or AAD56009 and any other protein that Has The Same Sequence as the foregoing. 

  

	 	1.47.	 “HER2 Effective Royalty Rate” shall have the meaning set forth in Section 5.4.3(a)
hereof. 

  

	 	1.48.	 “HER2 Product” shall mean any product containing a HER2 SMIP. 

 

	 	1.49.	 “HER2 SMIP” shall mean any SMIP directed against the HER2 Antigen or a portion thereof.

  

	 	1.50.	 “HSR Act” shall mean the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and
the rules and regulations promulgated thereunder. 

  

	 	1.51.	 “HSR Filing” shall mean filings by Wyeth and Trubion with the United States Federal Trade
Commission and the Antitrust Division of the United States Department of Justice of a Notification and Report Form for Certain Mergers and Acquisitions (as that term is defined in the HSR Act) with respect to the matters set forth in this Agreement,
together with all required documentary attachments thereto. 

  

	 	1.52.	 “HSR Clearance Date” shall mean the earliest date on which the Parties have actual knowledge
that all applicable waiting periods under the HSR Act with respect to the transactions contemplated hereunder have expired or have been terminated. 

  

	 	1.53.	 “IND” shall mean an Investigational New Drug Application, as defined in the FD&C Act, that
is required to be filed with the FDA before beginning clinical testing of a Licensed Product in human subjects, or an equivalent foreign filing. 

  
 6 

	 	1.54.	 “Indemnified Party” shall have the meaning set forth in Section 10.3 hereof.

  

	 	1.55.	 “Indemnifying Party” shall have the meaning set forth in Section 10.3 hereof.

  

	 	1.56.	 “Initial Term” shall have the meaning set forth in Section 3.3.1 hereof.

  

	 	1.57.	 “JDC” shall have the meaning set forth in Section 4.7 hereof. 

 

	 	1.58.	 “Joint Invention(s)” shall have the meaning set forth in Section 6.1.1 hereof.

  

	 	1.59.	 “Joint Know-How” shall mean that Know-How related to the Licensed Products that is jointly owned by the Parties in accordance with Section 6.1.1 of this Agreement. 

 

	 	1.60.	 “Joint Patent Committee” shall mean the committee described in Section 6.1.3 hereof.

  

	 	1.61.	 “Joint Patent Right(s)” shall mean those Patent Right(s) that claim Joint Know-How or Joint Invention(s). 

  

	 	1.62.	 “Joint Technology” shall mean the Joint Patent Rights, the Joint Inventions and the Joint Know-How. 

  

	 	1.63.	 “JPT” shall have the meaning set forth in Section 4.8 hereof. 

 

	 	1.64.	 “JRC” shall have the meaning set forth in Section 3.4.1 hereof. 

 

	 	1.65.	 “JRC Liaison” shall mean a JRC member designated by a Party as its “JRC Liaison” in
accordance with Section 3.4.3 hereof. 

  

	 	1.66.	 “Know-How” shall mean inventions, discoveries, data,
information, processes, methods, techniques, materials, technology, results or other know-how, whether or not patentable. 

 

	 	1.67.	 “Liabilities” shall have the meaning set forth in Section 10.1 hereof.

  

	 	1.68.	 “Licensed Product(s)” shall mean any Product(s) or Combination Product(s).

  

	 	1.69.	 “Licensed Target(s)” shall mean any Trubion Target(s) or Wyeth Target(s), so long as they
remain the subject of the licenses granted to Wyeth under this Agreement. 

  
 7 

	 	1.70.	 “Major Indication(s)” shall mean, with respect to any CD20 Product, any indication with a
prevalence-based patient population of at least two hundred thousand (200,000) patients in the United States, including, without limitation, non-Hodgkin’s lymphoma, rheumatoid arthritis, systemic lupus
erythematosus, Crohn’s disease and multiple sclerosis. 

  

	 	1.71.	 “Major Market Country” shall mean any of the United States, the United Kingdom, France,
Germany, Italy, Spain or Japan. 

  

	 	1.72.	 “Manufacturing” or “Manufacture” shall mean activities directed to producing,
manufacturing, processing, filling, finishing, packaging, labeling, quality assurance testing and release, shipping and storage of a product. 

  

	 	1.73.	 “NCBI” shall have the meaning set forth in Section 3.2.1 hereof. 

 

	 	1.74.	 “NDA” shall have the meaning set forth in Section 1.100 hereof. 

 

	 	1.75.	 “Net Combination Sale Amount” shall have the meaning set forth in Section 1.76 hereof.

  

	 	1.76.	 “Net Sales” shall mean the gross amounts charged for sales of Licensed Products (on which
payments are due under this Agreement) by Wyeth or its sublicensees to Third Parties, less the sum of (a) and (b) where (a) is a provision, determined under Generally Accepted Accounting Principles in the United States and in accordance
with Wyeth’s customary and usual accrual procedures, consistently applied, for the accrual of (i) trade, cash, quantity and wholesaler discounts or rebates (other than price discounts granted at the time of sale), if any, allowed or paid,
(ii) credits or allowances given or made for rejection or return of, previously sold Licensed Products or for retroactive price reductions (including Medicaid, managed care and similar types of rebates), (iii) taxes, duties or other
governmental charges levied on or measured by the billing amount (excluding income and franchise taxes), as adjusted for rebates and refunds, and (iv) charges for packing, freight, and shipping to the extent included in the invoice price and
(b) is a periodic adjustment (positive or negative, as applicable), determined under Generally Accepted Accounting Principles in the United States and in accordance with Wyeth’s customary and usual adjustment procedures, consistently
applied, of the provision determined in (a) to reflect amounts actually incurred for (i), (ii), (iii) and (iv) based on amounts actually invoiced or as separately set forth in agreements with Third Parties or as deducted or paid as required by
applicable law or regulations. (The deductions described in (i), (ii), (iii) and (iv) are referred to herein as “Permitted Deductions.”) In the case of any sale of Licensed Products for consideration other than cash, Net Sales shall
be calculated on the fair market value of the consideration received. 

  
 8 

 Notwithstanding the foregoing, if a Licensed Product is sold as a Combination Product (a
“Combination Sale”), the Net Sales for such Combination Product shall be the portion of such Combination Sale allocable to the Licensed Product determined as follows: 

Except as provided below, the Net Sales amount for a Combination Sale shall equal the gross amount invoiced for the Combination Sale, reduced
by the Permitted Deductions (the “Net Combination Sale Amount”), multiplied by the fraction A/(A+B), where: 
 A is
the invoice price, in the country where such Combination Sale occurs, of the Licensed Product contained in the Combination Product, if sold as a separate product in such country by Wyeth or its sublicensees, as the case may be, and B is the
aggregate of the invoice price or prices, in such country, of, products which collectively contain as their respective sole active ingredient such other pharmaceutically active compounds or substances, as the case may be, included in the Combination
Product, if sold separately in such country by Wyeth or its sublicensees, as applicable. 
 In the event that Wyeth or its sublicensees sell
the Licensed Product included in a Combination Product as a separate product in a country, but do not separately sell all of the other pharmaceutically active compounds or substances, as the case may be, included in such Combination Product in such
country, the calculation of the Net Sales amount for such Combination Sale shall be determined by multiplying the Net Combination Sale Amount by the fraction A/C where: 

A is the average wholesale price, in such country, charged by Wyeth or its sublicensees, as the case may be, for the Licensed Product
contained in such Combination Product, when sold as a separate product by Wyeth or its sublicensees, as applicable, and C is the average wholesale price, in such country, charged by Wyeth or its sublicensees, as applicable, for the entire
Combination Product. 
 In the event that Wyeth or its sublicensees do not sell the Licensed Product included in a Combination Product as a
separate product in a country where such Combination Sale occurs, but do separately sell products which collectively contain as their respective sole active ingredient all of the other pharmaceutically active compounds or substances, as the case may
be, included in the Combination Product in such country, the calculation of Net Sales resulting from such Combination Sale shall be determined by multiplying the Net Combination Sale Amount by the fraction
(C-D)/C, where: 

  
 9 

 C is the average wholesale price, in such country, charged by Wyeth or its
sublicensees, as the case may be, for the entire Combination Product, and D is the average wholesale price charged by Wyeth or its sublicensees, as the case may be, for the products which collectively contain as their sole active ingredient
such other pharmaceutically active compounds or substances, as the case may be, included in the Combination Product. 
 Where active
ingredient portions of a Combination Product are sold separately as other products but in different dosage strengths than are in the Combination Product, the calculation of the Net Sales amount for such Combination Product shall be based on
appropriate proration of the amounts of each active ingredient component included therein when applying the formulas set forth above. 

Where the calculation of Net Sales resulting from a Combination Sale in a country cannot be determined by any of the foregoing methods, the
calculation of Net Sales for such Combination Sale shall be that portion of the Net Combination Sale Amount reasonably determined in good faith by the Parties as properly reflecting the value of the Licensed Product included in the Combination
Product. 
 Notwithstanding the foregoing, Net Sales shall not include any reimbursement received by Wyeth or its sublicensees in respect of
the use of a Licensed Product in a country solely as part of a clinical trial prior to the receipt of marketing authorization required to commence commercial sales of such Licensed Product in such country. 

 

	 	1.77.	 “New Protein” shall have the meaning set forth in Section 1.45 hereof.

  

	 	1.78.	 “Niche Indication(s)” shall mean, with respect to any CD20 Product, any indication, including,
but not limited to, inflammatory myositis, for such CD20 Product other than a Major Indication. 

  

	 	1.79.	 “Notice of Breach” shall have the meaning set forth in Section 9.5 hereof.

  

	 	1.80.	 “Notice of Modification” shall have the meaning set forth in Section 9.5 hereof.

  

	 	1.81.	 “Notice of Termination” shall have the meaning set forth in Section 9.5 hereof.

  

	 	1.82.	 “Other Product” shall mean any product containing a SMIP directed against a Wyeth Target or a
portion thereof. 

  

	 	1.83.	 “Part(y/ies)” shall have the meaning set forth in the preamble hereof. 

  
 10 

	 	1.84.	 “Patent Rights” shall mean any and all (a) patents, (b) pending patent applications,
including, without limitation, all provisional applications, substitutions, continuations, continuations-in-part, divisions, renewals, and all patents granted thereon,
(c) all patents-of-addition, reissues, reexaminations and extensions or restorations by existing or future extension or restoration mechanisms, including, without
limitation, supplementary protection certificates or the equivalent thereof, (d) inventor’s certificates, and (e) all United States and foreign counterparts of any of the foregoing. 

 

	 	1.85.	 “Person” shall mean an individual, sole proprietorship, partnership, limited partnership,
limited liability partnership, corporation, limited liability company, business trust, joint stock company, trust, incorporated association, joint venture or similar entity or organization, including a government or political subdivision, department
or agency of a government. 

  

	 	1.86.	 “Permitted Deduction” shall have the meaning set forth in Section 1.76 hereof.

  

	 	1.87.	 “Phase I Clinical Study” shall mean a study of a Licensed Product in human subjects with the
endpoint of determining initial tolerance, safety or pharmacokinetic information in single dose, single ascending dose, multiple dose and/or multiple ascending dose regimens. 

 

	 	1.88.	 “Phase II Clinical Study” shall mean a study of a Licensed Product in human patients to
determine initial efficacy and dose range finding before embarking on Phase III Clinical Studies. 

  

	 	1.89.	 “Phase IIa Clinical Study” shall mean Trubion’s
TRU-015 Protocol 15001. 

  

	 	1.90.	 “Phase IIb Clinical Study” shall mean Trubion’s
TRU-015 Protocol 15002. 

  

	 	1.91.	 “Phase III Clinical Study” shall mean a pivotal study (whether or not denominated a
“Phase III” clinical study under applicable regulations) in human patients with a defined dose or a set of defined doses of a Licensed Product designed to ascertain efficacy and safety of such Licensed Product for the purpose of enabling
the preparation and submission of Regulatory Approval Applications to the competent Regulatory Authorities in a country of the Territory. 

  

	 	1.92.	 “Previously Deposited Protein” shall have the meaning set forth in Section 3.2.4(b)
hereof. 

  

	 	1.93.	 “Product” shall mean any CD20 Product, HER2 Product, or Other Product, or any Conjugate of any
CD20 Product, HER2 Product, or Other Product. 

  
 11 

	 	1.94.	 “Product Data and Filings” shall mean (a) all clinical protocols, studies, clinical data
and results used in or resulting from any clinical trial of any Licensed Product and (b) all INDs, Regulatory Approval Applications and Regulatory Approvals regarding any Licensed Product. 

 

	 	1.95.	 “Product License” shall have the meaning set forth in Section 2.1.1 hereof.

  

	 	1.96.	 “Product-Related Patent Rights” shall have the meaning set forth in Section 6.2.1 (a)
hereof. 

  

	 	1.97.	 “Provisional Excluded Target” shall mean a Target described in Section 3.2.4 hereof as a
Provisional Excluded Target. 

  

	 	1.98.	 “Receiving Party” shall have the meaning set forth in Section 7.1 hereof.

  

	 	1.99.	 “Recombinant DNA” shall mean the DNA sequences encoding any SMIP including, without
limitation, any DNA plasmid expression construct encoding any such SMIP. 

  

	 	1.100.	 “Regulatory Approval” shall mean the technical, medical and scientific licenses,
registrations, authorizations and approvals (including, without limitation, approvals of New Drug Applications (“NDAs”) or Biologic License Applications (“BLAs”), supplements and amendments,
pre- and post- approvals, pricing approvals, and labeling approvals) of any national, supra-national, regional, state or local regulatory agency, department, bureau, commission, council or other governmental
entity, necessary for the commercial Manufacture, distribution, marketing, promotion, offer for sale, use, import, export and sale of Licensed Product(s) in a regulatory jurisdiction in the Territory. For the sake of clarity, Regulatory Approval
shall not be deemed to have been obtained in a country other than the United States until any applicable governmental pricing approvals have also been obtained in such country. Regulatory Approval of a Licensed Product shall be deemed to have been
obtained in the United States immediately upon BLA approval for such Licensed Product in the United States. 

  

	 	1.101.	 “Regulatory Approval Application” shall mean an application submitted to the appropriate
Regulatory Authority seeking Regulatory Approval of a Licensed Product for use in one or more therapeutic indications in a regulatory jurisdiction within the Territory. 

 

	 	1.102.	 “Regulatory Authorit(y/ies)” shall mean any national (e.g., the FDA), supra-national
(e.g., the European Commission, the Council of the European Union, or the European Agency for the Evaluation of Medicinal Products), regional, state or local regulatory agency, department, bureau, commission, council or other governmental
entity in each country of the Territory involved in the granting of Regulatory Approval for a Licensed Product. 

  
 12 

	 	1.103.	 “Released Target” shall have the meaning set forth in Section 3.2.2 hereof.

  

	 	1.104.	 “Replacement Target” shall have the meaning set forth in Section 3.2.3 hereof.

  

	 	1.105.	 “Research Budget” shall have the meaning set forth in Section 3.5 hereof.

  

	 	1.106.	 “Research Plan” shall mean the written plan for the conduct of the Research Program described
in Section 3.5 hereof as approved and amended by the Parties in accordance with Section 3.5 hereof. 

  

	 	1.107.	 “Research Program” shall have the meaning set forth in Section 3.1 hereof.

  

	 	1.108.	 “Research Program Data” shall have the meaning set forth in Section 3.7 hereof.

  

	 	1.109.	 “Research Term” shall have the meaning set forth in Section 3.3.1 hereof.

  

	 	1.110.	 “Royalty Period” shall mean the period of time beginning on the date of the First Commercial
Sale of a Licensed Product in any country and, on a Licensed Product-by-Licensed Product and
country-by-country basis, extending until the earlier of (a) the termination of this Agreement pursuant to Article 9 hereof with respect to such Licensed Product in
such country or (b) the later of (i) the date on which the last Valid Claim included within the Trubion Technology ceases to be a Valid Claim, which Valid Claim would be infringed by the composition, Manufacture, use, sale, offer for sale or
importing of such Licensed Product in such country, or (ii)(A) with respect to CD20 Products, the ten (10) year anniversary of the First Commercial Sale for the first Major Indication of such CD20 Product in such country (provided, however,
that if such CD20 Product has received Regulatory Approval for a Niche Indication in such country but has not received Regulatory Approval for a Major Indication in such country, the Royalty Period as defined under and for purposes of this clause
(ii)(A) for such CD20 Product in such country shall be suspended beginning on the ten (10) year anniversary of the First Commercial Sale of such CD20 Product in such country until such time, if at all, as Regulatory Approval has been obtained
permitting the marketing of such CD20 Product for a Major Indication in such country, at which point such Royalty Period shall commence with respect to such CD20 Product for a Major Indication) and (B) with respect to each other Licensed Product,
the ten (10) year anniversary of the First Commercial Sale of such Licensed Product in such country. 

  

	 	1.111.	 “Signing Date” shall have the meaning set forth in the preamble hereof. 

  
 13 

	 	1.112.	 “SMIP(s)” or small modular immuno-pharmaceutical(s) shall mean a single chain polypeptide that
(i) is not a tetrameric immunoglobulin having two (2) heavy chains and two (2) light chains or a fragment of such an immunoglobulin, (ii) binds with specificity to a target antigen, (iii) has a binding domain, and
(iv) may have an effector domain which may or may not have effector function, including, but not limited to, any murine, chimeric, humanized or human forms thereof, any fragments, subunits, derivatives or multimeric forms thereof, any fusion
protein or multispecific forms thereof, and any other native, genetically engineered protein or protein scaffold. 

  

	 	1.113.	 “SMIP Improvement” shall mean an invention consisting of any modification to the
polynucleotide sequence encoding or the amino acid sequence of a SMIP, if the practice of such invention would infringe Patent Rights Controlled by Trubion at the time such invention is made. 

 

	 	1.114.	 “Specifically Binds” shall mean, in the case of a SMIP or other protein, the binding of such
SMIP or other protein to a Target (or a portion thereof) above the level of background binding and wherein such SMIP or other protein is designed or being developed to exert its biological effect through binding to such Target (or such portion
thereof). 

  

	 	1.115.	 “Successor Party” shall have the meaning set forth in Section 9.10.2(a) hereof.

  

	 	1.116.	 “Sued Party” shall have the meaning set forth in Section 6.2.3(b) hereof.

  

	 	1.117.	 “Target” shall mean a specific named human protein that is identified as a full length protein
of that name and further identified by up to three (3) GenBank accession numbers for its amino acid sequence, as well as any additional protein(s) that Has The Same Sequence as such specific named human protein. 

 

	 	1.118.	 “Target Candidate” shall have the meaning set forth in Section 3.2.1 hereof.

  

	 	1.119.	 “Territory” shall mean the entire world. 

 

	 	1.120.	 “Third Part(y/ies)” shall mean any Person(s) other than Wyeth or Trubion.

  

	 	1.121.	 “Trademark” shall mean those trademarks used in connection with the Commercialization of any
Licensed Product by Wyeth or its sublicensees hereunder. 

  

	 	1.122.	 “TRU-015” shall mean the chimeric SMIP directed
against the CD20 Antigen that is currently designated by Trubion as “TRU-015,” as further described on Exhibit 1.122 attached hereto. 

 

	 	1.123.	 “TRU-015 Product” shall mean any product containing TRU-015. 

  
 14 

	 	1.124.	 “Trubion” shall have the meaning set forth in the preamble hereof. 

 

	 	1.125.	 “Trubion Additional Third Party License” shall have the meaning set forth in
Section 6.2.3(a) hereof. 

  

	 	1.126.	 “Trubion Indemnified Party” shall have the meaning set forth in Section 10.1 hereof.

  

	 	1.127.	 “Trubion Know-How” shall mean any Know-How, other than the Joint Know-How, that (a) Trubion Controls as of the Effective Date or that comes into the Control of Trubion during the term of this Agreement
(other than through the grant of a license by Wyeth) and (b) relates to any Cell Lines, Conjugates, Licensed Products, Recombinant DNA, SMIPs, Licensed Targets, Target Candidates or the Development, Manufacture or use of any of the foregoing.

  

	 	1.128.	 “Trubion Lawyers” shall have the meaning set forth in Section 3.2.1 hereof.

  

	 	1.129.	 “Trubion Patent Rights” shall mean Patent Rights, other than Joint Patent Rights, that
(a) Trubion Controls as of the Effective Date or that come into the Control of Trubion during the term of this Agreement and (b) claim any Trubion Know-How. Those Trubion Patent Rights known to be
existing as of the Signing Date are listed on Exhibit 1.129 attached hereto. 

  

	 	1.130.	 “Trubion Target” shall mean each of the human CD20 Antigen and/or the HER2 Antigen, as the
context may require. 

  

	 	1.131.	 “Trubion Technology” shall mean Trubion’s interest in the Trubion Patent Rights, the
Trubion Know-How, the Joint Technology and the Research Program Data. 

  

	 	1.132.	 “Trubion Third Party Agreement(s)” shall mean the agreements specified on Exhibit 1.132
between Trubion and the indicated Third Parties that relate to the research, Development, Manufacture and/or Commercialization of Licensed Products under this Agreement. 

 

	 	1.133.	 “U.S. Wyeth Pharmaceuticals” shall have the meaning set forth in Section 12.5 hereof.

  

	 	1.134.	 “Valid Claim” shall mean a claim that (a) in the case of any unexpired United States or
foreign patent, shall not have been dedicated to the public, disclaimed, nor held invalid or unenforceable by a court or government agency of competent jurisdiction in an unappealed or unappealable decision, or (b) in the case of any United
States or foreign patent application, (i) shall not have been cancelled, withdrawn or abandoned, without being refiled in another application in the applicable jurisdiction, (ii) shall not have been finally rejected by an administrative
agency or other 

  
 15 

	 	
governmental action from which no appeal can be taken and (iii) shall not have been pending for more than seven (7) years, in either case which claim (if issued) would cover the
Manufacture, use or sale of any Licensed Product. For purposes of this definition, the time period for which a claim is pending shall begin on the priority date for such claim, and shall continue until such claim is either issued or is no longer
deemed to be a Valid Claim in accordance with the preceding sentence regardless of whether such claim is amended or refiled in another application in the applicable jurisdiction. If a claim of a patent application which ceased to be a Valid Claim
under (b) due to the passage of time later issues as part of a patent described within (a) then it shall again be considered to be a Valid Claim effective as of the issuance of such patent. 

 

	 	1.135.	 “Wyeth” shall have the meaning set forth in the preamble hereof. 

 

	 	1.136.	 “Wyeth Applied Technology” shall mean, with respect to any Licensed Product, that Wyeth
Technology which (a) Wyeth had applied to such Licensed Product prior to any termination of any rights under this Agreement with respect to such Licensed Product, provided that such Wyeth Technology is necessary or useful for the continued
research, Development, Manufacture or Commercialization of such Licensed Product as it exists at the time of such termination, or (b) Wyeth had incorporated into such Licensed Product prior to any termination of rights under this Agreement with
respect to such Licensed Product; provided that Wyeth shall use its Commercially Reasonable Efforts to sublicense or otherwise transfer rights under any Third-Party license to which the use or exploitation of such Wyeth Applied Technology is
subject; and further provided, however, that with respect to each of clauses (a) and (b) of this Section 1.136, such Wyeth Technology shall not include any of Wyeth’s conjugation technology. 

 

	 	1.137.	 “Wyeth Indemnified Party” shall have the meaning set forth in Section 10.2 hereof.

  

	 	1.138.	 “Wyeth Know-How” shall mean any Know-How, other than the Joint Know-How, that (a) Wyeth Controls as of the Effective Date or that comes into the Control of Wyeth (other than as a result of the licenses
granted by Trubion to Wyeth under Section 2.1 hereof) during the term of this Agreement and (b) relates to the Cell Lines, Conjugates, Recombinant DNA, Licensed Products, SMIPs, Target Candidates or Licensed Targets or the Development,
Manufacture, use or Commercialization of any of the foregoing. 

  

	 	1.139.	 “Wyeth Patent Rights” shall mean Patent Rights, other than the Joint Patent Rights, that (a)
Wyeth Controls as of the Effective Date or that come into the Control of Wyeth (other than as a result of the licenses granted by Trubion to Wyeth under Section 2.1 hereof) during the term of this Agreement and (b) claim any Wyeth Know-How. 

  
 16 

	 	1.140.	 “Wyeth Targets” shall mean the Targets designated by Wyeth under the Research Program, as
described in Section 3.2 hereof. 

  

	 	1.141.	 “Wyeth Technology” shall mean Wyeth’s interest in the Wyeth Patent Rights, the Wyeth Know-How, the Joint Technology and the Research Program Data. 

  

	2.	 LICENSES. 

  

	 	2.1.	 Licenses to Wyeth. 

 

	 	2.1.1.	 Exclusive Licenses. Subject to the terms and conditions of this Agreement, Trubion, effective as of the
Effective Date, hereby grants to Wyeth an exclusive license (exclusive even as to Trubion, except to the extent necessary for Trubion to perform its obligations under this Agreement), with the right to grant sublicenses in accordance with the
provisions of Section 2.4 hereof, under the Trubion Technology, to research, Develop, have Developed, make, have made, Manufacture, use, have used, import, have imported, export, have exported, distribute, have distributed, market, have
marketed, offer and have offered for sale, sell, have sold and Commercialize (subject to Section 4.11) Licensed Products in the Territory (the license granted under this Section 2.1.1 is sometimes referred to herein as the “Product
License”). 

  

	 	2.1.2.	 Retained Rights of Trubion. For the avoidance of doubt, but subject to Sections 2.3 and 3.2 hereof,
Trubion shall retain: (a) all rights under the Trubion Technology with respect to the research, Development, Manufacture, use and Commercialization of SMIPs that (i) Specifically Bind to Targets that are not Licensed Targets and
(ii) do not Specifically Bind to any Licensed Targets; and (b) the right to use SMIPs which Specifically Bind to one or more Licensed Targets in in vitro studies conducted solely as part of Trubion’s internal research efforts, provided,
however, that Trubion shall not provide any such SMIP (that Specifically Binds to a Licensed Target) to any Third Party or utilize any such SMIP (that Specifically Binds to a Licensed Target) in a collaboration with any Third Party, except with
Wyeth’s prior written consent. 

  

	 	2.2.	 License to Trubion. Wyeth hereby grants to Trubion a royalty-free
non-exclusive license, with no right to grant sublicenses, under the Wyeth Technology, solely for the purpose of, and limited to, Trubion’s use of the Wyeth Technology in connection with the Trubion
Technology to research, Develop, have Developed, make, have made, use and have used Licensed Products to fulfill its obligations under this Agreement. In addition, Wyeth hereby grants to Trubion the
non-exclusive license under Wyeth’s rights to Covered SMIP Improvements as set forth in greater detail in Section 6.1.2. 

  
 17 

	 	2.3.	 Exclusivity. 

  

	 	2.3.1.	 CD20 Product Exclusivity. Subject to Section 2.3.3, and except for Development of the CD20 Products
pursuant to the terms of this Agreement, neither Party shall Develop any human therapeutic product that contains a protein that Specifically Binds to the CD20 Antigen during the time period beginning on the Effective Date and ending on the earlier
of: (a) the First Commercial Sale of any CD20 Product for a Major Indication in a Major Market Country or (b) the termination of the licenses granted by Trubion to Wyeth under this Agreement with respect to all CD20 Products.

 Subject to Section 2.3.3, and except for Commercialization of the CD20 Products pursuant to the terms of this
Agreement, neither Party shall Commercialize any human therapeutic product that contains a protein that Specifically Binds to the CD20 Antigen during the time period beginning on the Effective Date and ending on the earlier of: (a) five (5)
years after the First Commercial Sale of any CD20 Product for a Major Indication in a Major Market Country or (b) the termination of the licenses granted by Trubion to Wyeth under this Agreement with respect to all CD20 Products. 

 

	 	2.3.2.	 HER2 Product Exclusivity. Subject to Section 2.3.3, and except for Development of the HER2 Products
pursuant to the terms of this Agreement, neither Party shall Develop any human therapeutic product that contains a protein that Specifically Binds to the HER2 Antigen during the time period beginning on the Effective Date and ending on the earlier
of: (a) the First Commercial Sale of any HER2 Product in any Major Market Country or (b) the termination of the licenses granted by Trubion to Wyeth under this Agreement with respect to all HER2 Products. 

Subject to Section 2.3.3, and except for Commercialization of the HER2 Products pursuant to the terms of this Agreement, neither Party
shall Commercialize any human therapeutic product that contains a protein that Specifically Binds to the HER2 Antigen during the time period beginning on the Effective Date and ending on the earlier of: (a) five (5) years after the First
Commercial Sale of any HER2 Product in any Major Market Country or (b) the termination of the licenses granted by Trubion to Wyeth under this Agreement with respect to all HER2 Products. 

  
 18 

	 	2.3.3.	 Limitations. The exclusivity provisions of Sections 2.3.1 and 2.3.2 above (a) shall not
apply to Wyeth’s Manufacture of any product for a Third Party pursuant only to a contract manufacturing or supply agreement between Wyeth and such Third Party where Wyeth is acting only as a contract manufacturer or supplier for such Third
Party, (b) shall in no way limit any of the licenses granted by Trubion to Wyeth under Section 2.1 hereof, and (c) shall in no way limit any of the retained rights of Trubion set forth in Section 2.1.2 hereof.

  

	 	2.4.	 Sublicensing. Wyeth may grant to one or more Third Parties sublicenses of the rights granted to
it under Section 2.1 hereof at any time; provided that Wyeth shall execute a written agreement with each such sublicensee and shall comply with the following: Each such sublicense (a) shall be subject and subordinate to, and
consistent with, the terms and conditions of this Agreement, (b) shall not in any way diminish, reduce or eliminate any of Wyeth’s obligations under this Agreement, (c) shall require each such sublicensee to comply with all applicable
terms of this Agreement, including to keep books and records, and permit Wyeth to audit (either directly or through an independent auditor) such books and records, and (d) shall provide that any such sublicensee shall not further sublicense
except on terms consistent with this Section 2.4. Wyeth shall provide Trubion with a copy of each such sublicense agreement within thirty (30) days after the execution thereof. Such copy may be redacted to exclude confidential, non-Licensed Product-related information and financial information (other than such financial information that is necessary for assessing the obligations to Trubion under this Agreement). Upon Trubion’s request
and at Trubion’s expense, Wyeth shall exercise its right to conduct an audit of a sublicensee’s books and records pertaining to the sale of a Licensed Product under any such sublicense agreement at the next time that conducting such an
audit is permissible under such sublicense agreement. Wyeth shall provide Trubion with a copy of the report of the findings made in any such audit. If such audit reveals that such sublicensee has understated its Net Sales by ten percent (10%) or
more, Wyeth shall be responsible for the costs of the audit. Wyeth shall remain responsible for its obligations hereunder and for the performance of its sublicensees (including, without limitation, making all payments due Trubion by reason of any
Net Sales of Licensed Products), and shall ensure that any such sublicensees comply with all relevant provisions of this Agreement. In the event of any uncured material breach by any sublicensee under a sublicense agreement that would constitute a
breach of Wyeth’s obligations under this Agreement, Wyeth will promptly inform Trubion in writing and shall take such action which in Wyeth’s reasonable business judgment will address such default;

  
 19 

	 	
provided, however, any such uncured material breach by such sublicensee of an obligation that would constitute a breach of Wyeth’s obligations under this Agreement shall be
deemed an uncured material breach of Wyeth hereunder unless Wyeth cures such material breach within the time provided under Section 9.5 hereof. 

  

	 	2.5.	 Direct Licenses to Affiliates. Wyeth may at any time request and authorize Trubion to grant licenses
within the scope of Section 2.1 directly to Affiliates of Wyeth by giving written notice designating to which Affiliate a direct license is to be granted. Upon receipt of any such notice, Trubion shall enter into and sign a separate direct
license agreement with such designated Affiliate of Wyeth. All such direct license agreements shall be consistent with the terms and conditions of this Agreement, except for such modifications as may be required by the laws and regulations in the
country in which the direct license will be exercised; provided, however, that Trubion shall have no obligation to enter into any such direct license agreement if the effect of entering into such agreement (and continuing as a
Party to this Agreement) would be to increase the level of obligations owed by Trubion, decrease the obligations owed to Trubion or the enforceability thereof, or decrease the consideration owed to Trubion relative to the obligations owed by or to,
or the consideration owed to, Trubion under this Agreement, had such direct license(s) not been granted. In countries where the validity of such direct license agreement requires prior government approval or registration, such direct license
agreement shall not become binding between the parties thereto until such approval or registration is granted, which approval or registration shall be obtained by Wyeth. All costs of making such direct license agreement(s), including Trubion’s
reasonable attorneys’ fees, under this Section 2.5 shall be borne solely by Wyeth. 

  

	 	2.6.	 Right of Reference. Trubion hereby grants to Wyeth a “Right of Reference,” as that term is
defined in 21 C.F.R. § 314.3(b), to any data Controlled by Trubion that relates to any CD20 Product (and any other Licensed Product, to the extent applicable), and Trubion shall provide a signed statement to this effect, if requested by Wyeth,
in accordance with 21 C.F.R. § 314.50(g)(3). 

  

	 	2.7.	 Section 365(n) of Bankruptcy Code. All rights and licenses now or hereafter granted under or
pursuant to any Section of this Agreement, including Sections 2.1 and 2.5 hereof, are rights to “intellectual property” (as defined in Section 101 (35A) of Title 11 of the United States Code, as amended (such Title 11, the
“Bankruptcy Code”)). In the event this Agreement is rejected under Section 365 of the Bankruptcy Code, Trubion hereby grants to Wyeth, subject to Wyeth’s obligations under Sections 365(n)(2)(A) and (B), a right of access and to
obtain possession of and to benefit from each of the following embodiments to the extent related to Wyeth’s exercise of its license rights to any Licensed Products or otherwise

  
 20 

	 	related to any rights or licenses granted under or pursuant to any Section of this Agreement: (i) copies of pre-clinical and clinical research data and results,
(ii) aliquots of laboratory samples, (iii) Licensed Product samples and inventory, (iv) Cell Lines expressing Licensed Products, libraries encoding Licensed Products or components thereof and sequences thereof, (v) copies of
laboratory notes and notebooks pertaining to Licensed Products, (vi) copies of data and results related to clinical trials of Licensed Products, (vii) regulatory filings and approvals of Licensed Products, (viii) rights of reference
in respect of regulatory filings and approvals of Licensed Products, and (ix) plasmid and vectors encoding Licensed Product SMIPs, all of which constitute “embodiments” of intellectual property pursuant to Section 365(n) of the
Bankruptcy Code, and (xi) all other embodiments of such intellectual property in Trubion’s possession or control. Recognizing that the embodiments described above may be useful or necessary to Trubion in connection with its continued
operation of its business, and that a Third Party may also have a right of access to such embodiment under Section 365(n) of the Bankruptcy Code or applicable non-bankruptcy law, where there is a fixed or
limited quantity of any biological material or other tangible item of such embodiment described above, Wyeth shall be entitled to a pro rata portion thereof. Trubion agrees not to interfere with Wyeth’s exercise under the Bankruptcy Code of
rights and licenses to intellectual property licensed hereunder and embodiments thereof in accordance with this Agreement and agrees to use Commercially Reasonable Efforts (short of any obligation of Trubion to incur expenses in connection
therewith) to assist Wyeth to obtain such intellectual property and embodiments thereof in the possession or control of Third Parties as reasonably necessary or useful for Wyeth to exercise such rights and licenses in accordance with this Agreement;
provided, however, that Trubion’s Commercially Reasonable Efforts for purposes of this Section 2.7 shall not be deemed to include an obligation to make payments to Third Parties to obtain such intellectual property rights and
embodiments thereof The Parties hereto acknowledge and agree that reimbursement payments pursuant to Sections 3.6 and 4.6 and all other payments by Wyeth to Trubion hereunder other than royalty payments pursuant to Section 5.4 and Additional
Research and Development Expense Payments under Section 5.3 do not constitute royalties within the meaning of Bankruptcy Code §365(n) or relate to licenses of intellectual property hereunder. 

 

	 	2.8.	 No Implied Rights. Except as expressly provided in this Agreement, neither Party shall be deemed by
estoppel or implication to have granted the other Party any license or other right with respect to any intellectual property of such Party. 

  
 21 

	3.	 RESEARCH PROGRAM. 

 

	 	3.1.	 Scope and Conduct of the Research Program. Under the terms and conditions set forth herein, Trubion and
Wyeth shall collaborate through one or more joint project teams in the conduct of a pre-clinical research program to identify and evaluate (a) SMIPs directed against Licensed Targets and (b) Licensed
Products, including CD20 Products, HER2 Products and Other Products (collectively, the “Research Program”). Such activities shall include, but not be limited to, the following: 

 

	 	(i)	 Licensed Product SMIP discovery, construction, initial expression and characterization, 

 

	 	(ii)	 Licensed Product SMIP optimization and preliminary Cell Line and bioprocess development in connection with such
SMIPs, 

  

	 	(iii)	 Biological activity evaluation of Licensed Products via in vitro assays and in vivo models,

  

	 	(iv)	 Pharmacology studies of Licensed Products to determine mechanisms of action, pharmacokinetics and
pharmacodynamics, 

  

	 	(v)	 Advanced Licensed Product process development, Licensed Product formulation, Cell Line optimization, and
generation of related working and master cell banks, 

  

	 	(vi)	 Pre-clinical toxicology and safety assessment studies with respect to
Licensed Products, and 

  

	 	(vii)	 Evaluation of Licensed Products and related SMIPs for use as part of Wyeth’s targeted chemotherapy
products. 

 Subject to and in accordance with the Research Plan and the Development Plan (to the extent applicable), the
JRC shall determine the appropriate activities to be undertaken by Trubion and Wyeth; provided, however, that, as of the Signing Date, the Parties anticipate that Trubion shall conduct activity (i) above (with input from Wyeth), Wyeth
shall. conduct activities (v), (vi) and (vii) above, and Trubion and Wyeth shall jointly conduct activities (ii), (iii) and (iv) above. The Research Program shall be conducted in accordance with the Research Plan, and each Party shall use
its Commercially Reasonable Efforts to perform all of its obligations under the Research Program in accordance with the Research Plan and current good laboratory practices. 
  

	 	3.2.	 Designation of Targets. 

 

	 	3.2.1.	 Target Candidates. Within thirty (30) days after the Effective Date, Wyeth shall provide
Trubion’s Vice President, Legal Affairs & Chief Patent Counsel with a list of up to thirty (30) Targets (each a “Target Candidate”) from which Wyeth shall have the exclusive right, until the second anniversary of the
Effective Date (or in the event that the Research Program is extended, until the third anniversary of the Effective Date), to designate up to ten (10) Wyeth Targets, in accordance with the following provisions (subject to Wyeth’s right under
Section 3.2.3 to designate as Wyeth Targets up to five (5) Targets (of the ten (10) Targets that Wyeth may designate as Wyeth Targets) 

  
 22 

	 	that are not Target Candidates at the time of selection). In the case of protein Targets that are Target Candidates, Wyeth shall designate each such Target Candidate on the list by its GenBank accession number provided
by the National Center for Biotechnology Information (“NCBI”) (including any nomenclature describing such Target Candidate that is provided therewith) or, if an NCBI GenBank accession number is not available for such Target Candidate, by
its nucleotide and amino acid sequences. For the avoidance of doubt, Wyeth may not designate as Target Candidates any Targets that are Excluded Targets. Subject to the following procedures, Trubion shall not undertake any research or Development
activities beyond Milestone One (as defined on Exhibit 3.2.1 attached hereto) of Trubion’s internal product development process, or propose to enter into or enter into any agreement with any Third Party with respect to any SMIP directed
against any Target Candidate or with respect to any Licensed Product containing such a SMIP, unless and until such Target Candidate becomes a Released Target, Excluded Target or Provisional Excluded Target. Trubion, through its Legal Department,
shall maintain a copy of the list of Target Candidates in a secure location. Trubion shall take reasonable measures and implement reasonable procedures to ensure that only its inside attorneys who are employees of its Legal Department and its
outside patent counsel (collectively, “Trubion Lawyers”) have knowledge of and access to Wyeth’s Target Candidate list. The Target Candidate list shall be considered Confidential Information of Wyeth, and except as expressly permitted
under this Section 3.2 or otherwise under this Agreement, Trubion shall not use or disclose the Target Candidate list or the information set forth therein to any of its Affiliates, to any Third Party, or to any employees, officers or agents of
Trubion other than Trubion Lawyers. For so long as a Target remains a Target Candidate, Trubion, through its Legal Department, shall implement reasonable procedures to maintain records of all Third Party inquiries to Trubion and Trubion’s
responses to same, relating to the Target Candidate list made pursuant to this Section 3.2. The Trubion Legal Department shall also maintain the list of Released Targets, Excluded Targets and Provisional Excluded Targets in accordance with the
provisions of Sections 3.2.2 and 3.2.4. In the event of a bona fide dispute arising under this Agreement relating to the Target selection process described in this Section 3.2, Trubion shall provide to an independent Third Party
selected by Wyeth and reasonably acceptable to Trubion access to the lists of Target Candidates, Released Targets, Excluded Targets and Provisional Excluded Targets and records and processes related 

  
 23 

	 	thereto (to the extent relevant to the bona fide dispute) maintained by Trubion in accordance with this Section 3.2. Such independent Third Party may only communicate to Wyeth whether or not the Target
selection process was properly performed by Trubion’s Lawyers. 

  

	 	3.2.2.	 Released Targets. On or before the first anniversary of the Effective Date, Wyeth, by written notice to
Trubion’s Vice President, Legal Affairs & Chief Patent Counsel, shall identify at least fifteen (15) Target Candidates from the list delivered pursuant to Section 3.2.1 (inclusive of any Target Candidates that have become
Released Targets during such period pursuant to Section 3.2.4 hereof), which from the date of such identification shall cease to be Target Candidates (each, a “Released Target”). At the time that a Target Candidate becomes a Released
Target, Trubion, subject to Section 2.8, shall be free to undertake research and Development activities independent of obligations under this Agreement, and to enter into discussions or an agreement with a Third Party, with respect to SMIPs
directed against any such Released Target or any other activities in connection with such Released Target. On or before the second anniversary of the Effective Date, Wyeth, by written notice to Trubion, shall identify such additional Target
Candidates from the list delivered pursuant to Section 3.2.1, if any, as additional Released Targets, such that there are no more than ten (10) Target Candidates remaining on the list delivered pursuant to Section 3.2.1 (less the number of
Wyeth Targets that were Target Candidates at the time of selection as a Wyeth Target(s) pursuant to Section 3.2.3), which from the date of such identification shall cease to be Target Candidates and, thereafter each shall also become a Released
Target. At the end of the Research Term, all remaining Target Candidates, if any, shall become Released Targets. 

  

	 	3.2.3.	 Wyeth Targets. Wyeth Targets shall be designated only from either (a) Target Candidates that have
not become Released Targets, or (b) any other Target (including a Released Target that is or becomes available, as described below) that is not then an Excluded Target or a Provisional Excluded Target; provided, however, that no
more than five (5) of the Targets designated by Wyeth as Wyeth Targets may be Targets that are not Target Candidates at the time of selection. Subject to the foregoing sentence, Wyeth shall designate: (y) at least two
(2) Target Candidates or other Targets as Wyeth Targets on or before the first anniversary of the Effective Date; and (z) up to ten (10) Target Candidates or other Targets (inclusive of those designated as Wyeth Targets during the first
year) as Wyeth 

  
 24 

	 	Targets on or before the second anniversary of the Effective Date; provided, however, if Wyeth does not designate a total of ten (10) Wyeth Targets on or before such second anniversary, then the lesser number of
Wyeth Targets so designated shall be the total number of Wyeth Targets under this Agreement unless Wyeth extends the Research Program, in which case Wyeth may designate, before the third anniversary of the Effective Date, one or more additional
Wyeth Targets (up to a cumulative total of ten (10) in the aggregate). For the avoidance of doubt and subject to the following sentence, Wyeth may designate only up to a total of ten (10) Wyeth Targets from the Effective Date of this Agreement
through the end of the Research Program (even if extended). During the term of the Research Program, Wyeth shall have the right to abandon and replace up to three (3) of the Wyeth Targets with other Targets designated as described above;
provided that each such replacement Target (a “Replacement Target”) must be unanimously approved (such approval not to be unreasonably withheld) by the JRC (without resort to the JRC dispute resolution procedure) to be designated as
a Wyeth Target. In the event that Wyeth nominates as a Wyeth Target (whether as a proposed initial designation of a Wyeth Target or as a replacement designation as a Wyeth Target) a Target that is not then a Target Candidate, Trubion’s Legal
Department, within ten (10) business days after receiving written notice of such nomination, shall determine and advise Wyeth in writing whether such Target is an Excluded Target or a Provisional Excluded Target, as described below (and shall
indicate whether such Target is an Excluded Target or is a Provisional Excluded Target). If such Target is an Excluded Target or a Provisional Excluded Target, it shall not be eligible to be considered a Wyeth Target. If a proposed Replacement
Target is not an Excluded Target or a Provisional Excluded Target, then the JRC shall either approve or disapprove designation of such proposed Replacement Target as a Wyeth Target; provided that the original Wyeth Target that Wyeth proposes
to replace shall be automatically deemed a Released Target upon the JRC’s approval of the designation of the Replacement Target. 

  
 25 

	 	3.2.4.	 Excluded Targets. Excluded Targets are not eligible to be Wyeth Targets for so long as they
remain Excluded Targets. The Targets deemed “Excluded Targets” as of the Effective Date are set forth in Exhibit 3.2.4 attached hereto. Trubion may add additional Targets as Excluded Targets or Provisional Excluded Targets (which
may be selected from Released Targets and other Targets, but would not include any Wyeth Targets or any Target Candidate that has not become a Released Target) in accordance with the following procedures: 

 

	 	(a)	 During the period when at least one Target Candidate exists, and upon the written request of a potential Third
Party collaborator and/or licensee of Trubion pertaining to the identification, generation and/or Development of SMIPs directed against a Target or Targets, Trubion’s Legal Department shall promptly determine whether or not any of such Targets
is a Wyeth Target. 

  

	 	(b)	 With respect to any Target newly submitted by a Party to Trubion’s Legal Department hereunder,
Trubion’s Lawyers will determine whether such submitted Target Has The Same Sequence as any specific, previously deposited protein within the list of Licensed Targets, Target Candidates, Released Targets, Excluded Targets and Provisional
Excluded Targets available to Trubion’s Lawyers (each a “Previously Deposited Protein”). By way of example only, if the New Protein consists of 100 amino acids, and any contiguous sequence of 90 amino acids contained in the Previously
Deposited Protein has at least 90% sequence identity to any contiguous sequence of 90 amino acids in the New Protein (that is, at least 81 of the 90 contiguous amino acids in such Previously Deposited Protein sequence are identical to any 81 of any
90 contiguous amino acids in such New Protein), then the New Protein Has The Same Sequence as the Previously Deposited Protein. Should Wyeth designate a Target that is not a protein, the Parties agree to negotiate in good faith the procedure for
identifying and testing whether a subsequent proposed non-protein Target is the “same as” such designated non-protein Target for purposes of this Section 3.2.

  

	 	(c)	 If Trubion’s Legal Department determines, in accordance with Section 3.2.4(b) above, that any such
Target is a Wyeth Target, Trubion shall not proceed with such potential Third Party collaboration or license with respect to such Target. If any of such Targets is not a Wyeth Target or a Target Candidate, such Target shall automatically be deemed a
“Provisional Excluded Target”. If such Target is a Target Candidate, Trubion shall notify Wyeth in writing of Trubion’s request that a Target Candidate be recategorized as a Released Target, in order for Trubion to be able to enter
substantive negotiations with such Third Party regarding such Target that is a Target 

  
 26 

	 	
Candidate (i.e., Trubion shall “Put” such Target Candidate to Wyeth). Trubion shall have no obligation to notify Wyeth of the identity of such Third Party or the purpose of the
proposed collaboration or license. From the date that Trubion “Puts” such Target Candidate to Wyeth, Wyeth shall have ninety (90) days with respect to such Puts made to Wyeth prior to the first anniversary of the Effective Date, and
shall have thirty (30) days with respect to such Puts made thereafter, to notify Trubion in writing whether Wyeth designates such Target Candidate as a Wyeth Target or recategorizes such Target Candidate as a Released Target. If Wyeth fails to
notify Trubion within such ninety (90)-day or thirty (30)-day period, respectively, then such Target Candidate shall automatically be deemed a Released Target. Any such
Released Targets shall be deemed to be Provisional Excluded Targets. 

  

	 	(d)	 If Trubion and such potential Third Party collaborator and/or licensee do not enter into a definitive agreement
regarding such Provisional Excluded Target within twelve (12) months after the date that such Target is deemed a Provisional Excluded Target (such 12-month period being subject to a three (3) month
extension by Trubion, if Trubion declares, in writing, to Wyeth that at least one draft definitive agreement has been exchanged between Trubion and such potential Third Party collaborator and/or licensee), thereafter such Provisional Excluded Target
would revert to being a Released Target. If Trubion and such potential Third-Party collaborator and/or licensee enter into a definitive agreement within the time period provided above, such Provisional Excluded Target shall be deemed an Excluded
Target. 

  

	 	(e)	 During the period when at least one (1) Target Candidate exists, if Trubion itself identifies internally a
Target that has progressed to Milestone One (as defined in Exhibit 3.2.1 attached hereto) of Trubion’s internal product development process, Trubion’s Legal Department shall promptly determine whether or not such Target is a Target
Candidate. If such Target is not a Target Candidate, such Target shall be deemed an Excluded Target. If Trubion thereafter abandons work on such Excluded Target, Trubion shall notify Wyeth in writing that Trubion has abandoned work on such Excluded
Target and such Excluded Target shall thereafter be deemed a Released Target. If such Target is a Target Candidate, Trubion may Put such Target Candidate to Wyeth. From the date that 

  
 27 

	 	
Trubion Puts such Target Candidate to Wyeth, Wyeth shall have ninety (90) days with respect to such Puts made to Wyeth prior to the first anniversary of the Effective Date, and shall have
thirty (30) days with respect to such Puts made thereafter, to notify Trubion in writing whether Wyeth designates such Target Candidate as a Wyeth Target or recategorizes such Target Candidate as a Released Target. If Wyeth fails to notify
Trubion within such ninety (90)-day or thirty (30)-day period, respectively, then such Target Candidate shall automatically be deemed a Released Target. Any such
Released Target shall be deemed to be Excluded Target. If Trubion thereafter abandons work on any such Excluded Target, Trubion shall notify Wyeth in writing that Trubion has abandoned work on such Excluded Target and such Excluded Target shall
thereafter be deemed a Released Target. 

  

	 	(f)	 With respect to the Puts described in (c) and (e) above, Trubion shall not be permitted to Put more than
two (2) Target Candidates to Wyeth during the first six (6) full Calendar Quarters of the Research Program. 

  

	 	3.3.	 Term and Termination of the Research Program. 

 

	 	3.3.1.	 Research Term. The term of the Research Program (the “Research Term”) shall begin on the
Effective Date and shall continue until the three (3) year anniversary of the Effective Date (the “Initial Term”), subject to extension as described below. At Wyeth’s option (exercisable by providing written notice to Trubion no
later than six (6) months prior to the end of the Initial Term of the Research Program or any extension year thereof), the Research Term may be extended for up to two (2) additional one (1) year periods and, thereafter, shall be renewable
annually only upon mutual written agreement of the Parties. 

  

	 	3.3.2.	 Termination of Research Program by Wyeth. Commencing on the first anniversary of the Effective Date,
Wyeth shall have the right to terminate the Research Program, at will, at any time, in its entirety, upon one (1) year prior written notice to Trubion; provided that Trubion shall have no obligation after the effective termination
date to complete any Research Program activities in connection with any Trubion Target, Wyeth Target, SMIP or Licensed Product. Such termination of the Research Program shall not constitute termination of this Agreement and shall not affect the
Parties’ rights and obligations under this Agreement other than those relating to the Research Program. 

  
 28 

	 	3.4.	 Joint Research Committee. 

 

	 	3.4.1.	 Composition. Within thirty (30) days after the Effective Date, the Parties shall establish a Joint
Research Committee (the “JRC”) to oversee the Research Program. The JRC will be in effect only during the Research Term. The JRC shall be composed of three (3) representatives from each Party. Each Party may replace any of its
representatives at any time upon written notice to the other Party. From time to time, the JRC may establish subcommittees to oversee particular projects or activities, and such subcommittees shall be constituted as the JRC decides.

  

	 	3.4.2.	 Responsibilities. The JRC shall be responsible for establishing, reviewing and recommending
modifications and updates to the Research Plan, including the Research Budget, in accordance with Section 3.5 hereof, monitoring and reporting to the Parties on activities conducted pursuant to the Research Plan, and for such other functions as
agreed by the Parties. 

  

	 	3.4.3.	 Meetings. The JRC shall meet as soon as practicable after it is established by the Parties and,
thereafter, at such additional times as the Parties deem appropriate, not less frequently than quarterly. Each Party shall designate one of its JRC members as its “JRC Liaison” to co-chair meetings,
prepare and circulate JRC meeting agendas and JRC meeting minutes. The meetings of the JRC shall be held in the United States, and shall alternate between the Parties’ business locations or as otherwise decided by the JRC. JRC meetings may be
conducted in person, by telephone or by videoconference. Each Party shall use reasonable efforts to cause its representatives to attend the meetings of the JRC. If a representative of a Party is unable to attend a meeting, such Party may designate
an alternate member to attend such meeting in place of the absent member. 

  

	 	3.4.4.	 Voting. Decisions of the JRC shall be made by unanimous consent, with each Party having one vote. The
JRC may act without a meeting if an action by unanimous written consent is signed by each Party’s JRC Liaison. 

  

	 	3.4.5.	 Dispute Resolution. If the JRC is unable to reach agreement on a matter, the matter may be referred, at
the request of either Party, for resolution through good faith discussions between Wyeth’s Executive Vice President of Discovery Research and Trubion’s Senior Vice President of Research and Development or their respective designees.
Notwithstanding the foregoing, in the event the JRC cannot promptly resolve a disagreement or a 

  
 29 

	 	voting deadlock regarding the Research Program, Wyeth’s Executive Vice President of Discovery Research shall have the right to cast a tie-breaking vote to resolve any such
disagreement or voting deadlock, such right and tie-breaking authority being subject to the terms and conditions of this Agreement. 

 

	 	3.4.6.	 Minutes. The JRC shall keep accurate and complete minutes of its meetings that record all proposals and
recommendations made, and all actions and decisions taken. The JRC minutes shall not be effective until approved in writing by each Party’s JRC Liaison. All records of the JRC shall be available at all times to each Party.

  

	 	3.5.	 Research Plan. The Parties shall use their Commercially Reasonable Efforts to develop and approve a
complete Research Plan (including a corresponding Research Budget) within sixty (60) days of the Effective Date. The Parties shall ensure that the Research Plan is consistent with the terms and conditions of this Agreement, and the Research
Plan shall not impose obligations on either Party that are inconsistent with the terms of this Agreement. The Research Plan shall set forth generally (a) the activities to be undertaken by the Parties under the Research Program consistent with
the terms of Section 3.1, (b) the utilization of ten (10) Trubion FTEs in conducting such activities, (c) the anticipated schedule on which such activities are to be conducted, (d) the desired deliverables to be provided by each
Party with respect to each Licensed Target that is the subject of the Research Program, and (e) the annual budget for non-ordinary expenses (as described in Section 3.6.1 below) to be incurred by
Trubion under the Research Program (the “Research Budget”). The JRC shall review the Research Plan, including the Research Budget, on at least an annual basis and submit any proposed modifications or updates to the Parties for review and
approval; any such modifications or updates shall not become effective until approved in writing by an authorized officer of each of the Parties. The Parties shall review and consider any such proposed modifications or updates on an expeditious
basis. The Parties shall promptly amend the Research Plan from time to time to address the performance of the Research Program as it relates to any Licensed Targets designated by Wyeth in accordance with Section 3.2 above.

  

	 	3.6.	 Funding of the Research Program. 

 

	 	3.6.1.	 Research Funding. During each year of the Research Term (as it may be extended), Wyeth shall pay Trubion
Three Million Dollars ($3,000,000) per year for services performed in accordance with the Research Plan. Trubion shall commit to the Research Program ten (10) FTEs per year to provide services in furtherance of the Research Program in accordance
with the Research Plan. For the avoidance of doubt, Trubion may, at its 

  
 30 

																							
	 Key Activities
	  	Feb	  	March	  	April	  	May	  	June	  	July	  	August	  	September	  	October	  	November	  	December

CONFIDENTIAL                 

Planned expenditures/FTEs for Trubion: 

~ $90,000 for purchase of phage specific for TRU-015 for use in detection assays 

hu-TRU-015 
 Mo Bio: 3.5 

Assay: 1.0 
 PD: 1.0 

her2neu 
 Mo Bio: 1.5 

Assay: 1 
 PD: 0.5 

Up to 2 additional FTE’s may be expended by Project Management and R&D 

management 
  

					
	JRC Wyeth Representative:	  		  	JRC Trubion Representative:
			
	  
	  		  	 Kendall M. Mohler

	        Name	  		  	Name
			
	  
	  		  	 /s/ Kendall M. Mohler

	        Signature	  		  	Signature
			
	  
	  		  	 3/9/06

	        Date	  		  	Date

 Research Plan for Joint Research Committee- 

Wyeth/Trubion Alliance 1Q 2006 

CONFIDENTIAL                 

 

			
	Team members	  	JRC
	Last updated	  	    20-Feb-06

  

																							
	 Key Activities
	  	Feb	  	March	  	April	  	May	  	June	  	July	  	August	  	September	  	October	  	November	  	December

 Development of CD20 humanized SMIP for
Inflammation and Oncology Indications 
 L. Tchistiakov Wyeth contact for DNA constructs 

9 versions of SMIP for further analysis: for Oncology: 3 binding domains, all with csc hinge, WT-Fc. For Inflammation, 3 binding domains, csc versus scc
hinge, all with aa 331 mutations 
 Trubion to generate additional humanized binding domain(s) (e.g., 018009) for in vitro testing 

9 Binding domain candidates: Fresh protein generated and tested at Trubion 

Trubion to generate additional activity data (CDC, ADCC) on fresh batches of nine product candidates 

DNA being transferred to Wyeth for activity confirmation. ATC/BEP and Andover to work sequentially 

Top four constructs will be selected for manufacturability studies 

Wyeth to send supernatants to Trubion for in vitro testing 

Trubion to transfer assays and reagents for bioactivity testing to Wyeth 

Trubion to provide chimeric lead molecule and CDC null version for testing in Wyeth oncology models 

Trubion to evaluate linker versions to evaluate impact on aggregation 

Trubion to assemble data and initiate patent strategy on second generation anti-CD20 

Selection of pre-development candidate 
 Pre-development
assessment of candidate and generation of data for entry into development 

																							
	 Key Activities
	  	Feb	  	March	  	April	  	May	  	June	  	July	  	August	  	September	  	October	  	November	  	December

CONFIDENTIAL                 

Develop strategy to identify and generate optimal SMIP to Her2 for Oncology Indication 

Pursue multiple routes in parallel 
 Obtain mouse monoclonal
antibodies using synthetic peptide 
  

	 	•	 	 Can use overlapping sequences 

 

	 	•	 	 Also try conventional approach to allow hitting epitopes outside of stump 

Trubion generates her2 constructs for phage display- soluble ectodomain constructs 

and cell surface expressed cell lines 
 Carry-out phage display
with multiple constructs 
 Team to meet to agree path forward 

Expression and efficacy analysis 
 Determine possibility of
X-ray crystallography at Wyeth for CD20 SMIP 
 Initiate research on additional targets for SMIP generation 

Identify initial targets to be pursued 
 Planned
expenditures/FTEs for Wyeth: 
 $65,000-130,000 outside services for monoclonal antibody production 

hu-TRU-015 
 BT: 2.0 

ONC: 0.5 
 INF: 1.0 

BRITT: 1.0 
 her2neu 

BT: 1.5 
 ONC: 1.0 

BRITT: 0.5 
 New targets: 

BT: 1.5 
 ONC: 1.0 

INF: 0.5 
 Up to 2 additional FTEs may be expended by Project
Management, Portfolio Management, and Biological Technologies management 

CONFIDENTIAL                 

Planned expenditures/FTEs for Trubion: 

~ $90,000 for purchase of phage specific for TRU-015 for use in detection assays 

hu-TRU-015 
 Mo Bio: 3.5 

Assay: 1.0 
 PD: 1.0 

her2neu 
 Mo Bio: 1.5 

Assay: 1 
 PD: 0.5 

Up to 2 additional FTE’s may be expended by Project Management and R&D 

management 
  

					
	JRC Wyeth Representative:	  		  	JRC Trubion Representative:
			
	 

  
	  		  	  

	        Name	  		  	Name
			
	 

  
	  		  	  

	        Signature	  		  	Signature
			
	 May 16, 2006
	  		  	  

	        Date	  		  	Date

 sole expense and discretion, devote more than ten (10) FTEs from time to time to provide
services in furtherance of the Research Program. The Three Million Dollars in research funding described above shall be increased automatically once per calendar year by the percentage change in the U.S. Consumer Price Index, All Urban Consumers
over the previous year; provided, however, that no increase shall be effective prior to January 1, 2007. Trubion shall be solely responsible for expenses incurred by Trubion for ordinary equipment, materials and supplies utilized by
Trubion in performing its activities under the Research Program; provided, however, that Wyeth shall reimburse Trubion for those out-of-pocket, non-ordinary expenses incurred by Trubion in accordance with the Research Plan and Research Budget in acquiring access to animal models, vendor services or equipment that are necessary for, and to be used primarily
in connection with, the performance of Trubion’s activities under the Research Program (for example, including unique equipment or the Manufacture of Products by Third Parties, but not including common laboratory or consumable supplies such as
laboratory animals, pipettes, test tubes, petri dishes, reagents, and the like). Trubion shall provide to Wyeth, prior to the first day of each Calendar Quarter, a forecast of such expenses (by major expense category, on an accrual basis)
reimbursable under this Section 3.6.1 which Trubion expects to incur during such Calendar Quarter and the subsequent three Calendar Quarters, in each case shown by month. Other than the foregoing amounts and except as otherwise expressly
provided in this Agreement, each Party shall be solely responsible for its costs and expenses incurred in performing its obligations under the Research Program. 
  

	 	3.6.2.	 Reimbursement Payments. Reimbursement to be made to Trubion by Wyeth pursuant to
Section 3.6.1 will be made pursuant to invoices submitted by Trubion to Wyeth no more often than once with respect to any Calendar Quarter, within thirty (30) days of the end of such Calendar Quarter. Payment shall be due within forty-five
(45) days after Wyeth receives such an invoice from Trubion. Each invoice must be accompanied by supporting documentation sufficiently demonstrating the expense so paid on a cash basis (such as receipts for out-of-pocket expenses and other written documentation reasonably acceptable to Wyeth) and by a certificate executed by Trubion’s VP, Finance & Administration, of the number of FTEs used by
Trubion in such Calendar Quarter in performing Trubion’s obligations under the Research Program. Except as approved in writing in advance by Wyeth, Wyeth shall not be obligated to reimburse Trubion for amounts in excess of the applicable
budgeted amounts in the Research Budget. 

  
 31 

	 	3.6.3.	 Records and Audits. During the Research Term, Trubion shall keep books and accounts of record in
connection with the expenses reimbursable under Section 3.6.1 hereof in accordance with GAAP and in sufficient detail to permit accurate determination of all figures necessary for verification of costs to be reimbursed hereunder. Trubion shall
maintain such cost records for a period of at least three (3) years after the end of the calendar year in which they were generated in order to enable audit of such records as set forth below. Upon thirty (30) days prior written notice from Wyeth,
Trubion shall permit an independent certified public accounting firm of nationally recognized standing selected by Wyeth and reasonably acceptable to Trubion, to examine, at Wyeth’s sole expense, the relevant books and records of Trubion as may
be reasonably necessary to verify the amount of reimbursable out-of-pocket expenses incurred. An examination by Wyeth under this Section 3.6.3 shall occur not more than
once in any calendar year and shall be limited to the pertinent books and records for any calendar year ending not more than thirty six (36) months before the date of the request. The accounting firm shall be provided access to such books and
records at Trubion’s facility(ies) where such books and records are normally kept and such examination shall be conducted during Trubion’s normal business hours. Trubion may require the accounting firm to sign a standard non-disclosure agreement before providing the accounting firm access to Trubion’s facilities or records. The accounting firm shall provide both Trubion and Wyeth a written report disclosing whether the
certificates and invoices submitted by Trubion under Section 3.6.2 are correct or incorrect and the specific details concerning any discrepancies. No other information shall be provided to Wyeth. If the accounting firm determines that the aggregate
amount of out-of-pocket expenses actually incurred by Trubion was less than the amount reimbursed by Wyeth during the period covered by the audit, Trubion shall refund
the excess payments to Wyeth within thirty (30) days of its receipt of the auditor’s report so concluding (or, if later, within fifteen (15) days after resolution of a bona fide objection by Trubion to the findings in such report).
If the amount to be refunded exceeds more than ten percent (10%) of the amount that was properly payable, Trubion shall reimburse Wyeth for the cost of the audit. All information of Trubion which is subject to review under this Section 3.6.3 shall
be deemed to be Confidential Information of Trubion subject to the provisions of Article 7, and such Confidential Information shall not be disclosed to any Third Party or used for any purpose other than verifying the information provided by Trubion
to Wyeth; provided, however, that such Confidential Information may be disclosed to Third Parties only to the extent necessary to enforce Wyeth’s rights under this Agreement, as may be necessary for Wyeth to exercise its rights under
this Agreement, or as otherwise expressly permitted under this Agreement. 

  
 32 

	 	3.7.	 Data and Deliverables. During the Research Term, each Party will use Commercially Reasonable Efforts to
promptly provide to the other Party the data or desired deliverables specified in the Research Plan, including, without limitation, (a) SMIPs, Recombinant DNA, and Cell Lines, to the extent related to Licensed Targets and/or Licensed Products,
(b) activity evaluation of the items listed in (a) obtained from in vitro or in vivo assays, pharmacology studies, process development data, drug product formulation data, toxicology and safety studies, and evaluation of
chemotherapy conjugates, but only to the extent and in the manner that items listed in (a) and (b) are set forth in the Research Plan. Each Party shall also disclose to the other Party in writing all data, information, inventions, techniques
and discoveries (whether patentable or not) arising out of the conduct of the Research Program. Disclosure of all such aforementioned inventions and discoveries shall be delivered to the other Party in a manner mutually agreed upon by the Joint
Patent Committee. Subject to the terms and conditions of this Agreement, each Party shall have the right to use any data or information generated under the Research Program for its permitted activities under the Research Program and this Agreement
(collectively, “Research Program Data”). TRUBION MAKES NO REPRESENTATION OR WARRANTY, EITHER EXPRESS OR IMPLIED, THAT IT WILL BE ABLE TO SUCCESSFULLY DISCOVER, DEVELOP OR DELIVER ANY SMIP DIRECTED AGAINST A LICENSED TARGET OR ANY LICENSED
PRODUCT. 

  

	 	3.8.	 Alliance Managers. Each Party shall designate a single alliance manager, who shall perform such duties
relating to the day-to-day worldwide coordination of the collaboration contemplated by this Agreement as are determined by the JRC and the JDC. Such alliance managers
shall have experience and knowledge appropriate for managers with such project management responsibilities. Such alliance managers may attend, as non-voting members, any meetings of the committees contemplated
by this Agreement as deemed fit by such committees. Each Party may change its designated alliance manager from time to time upon notice to the other Party. 

  
 33 

	4.	 PRODUCT DEVELOPMENT, MANUFACTURING, COMMERCIALIZATION AND REGULATORY MATTERS. 

 

	 	4.1.	 Product Development. Except as otherwise expressly provided in Articles 2 and 3 hereof and in this
Article 4, Wyeth shall have the sole authority, at its expense, for the Development of Licensed Products, including the initiation and conduct of clinical trials. Wyeth shall be responsible for the Development of and shall use its Commercially
Reasonable Efforts to Develop Licensed Products throughout the Territory where it is Commercially Reasonable to do so (it being understood that Wyeth shall have the sole discretion to select those countries in which it will conduct clinical studies
of Licensed Products and, when Commercially Reasonable to do so, to delay or discontinue the Development of any Licensed Product directed against a particular Licensed Target in favor of pursuing Development of another Licensed Product directed
against such Licensed Target). When appropriate based on the data obtained during Development, Wyeth shall use its Commercially Reasonable Efforts to secure Regulatory Approval for Licensed Products in the Territory. 

 

	 	4.2.	 Transfer of Product Data and Filings. Upon Wyeth’s reasonable request and in consultation with the
JDC from time to time during the term of this Agreement and to the extent permitted by applicable law, Trubion shall assign and transfer to Wyeth Trubion’s entire right, title and interest in and to any of the Product Data and Filings pursuant
to an instrument to such effect in form and substance reasonably satisfactory to Wyeth and shall perform all other actions reasonably requested by Wyeth to effect and confirm such transfer. The Parties shall cooperate through the JDC to ensure that
assignment and transfer of Trubion’s right, title and interest in and to Product Data and Filings relating to CD20 Products is made in a manner that does not impede Trubion’s activities and responsibilities under Section 4.6. After
receipt of Wyeth’s request consistent with the foregoing, Trubion shall provide to Wyeth, at Wyeth’s expense, within sixty (60) days of receipt of such request, complete copies of such Product Data and Filings, including, without
limitation, relevant clinical data, INDs, additional regulatory filings with FDA or other Regulatory Authorities, supplements or amendments thereto, all written correspondence with FDA or other Regulatory Authorities regarding the regulatory
filings, and all existing written minutes of meetings and memoranda of conversations between Trubion (including, to the extent practicable, Trubion’s investigators) and FDA or other Regulatory Authorities in Trubion’s possession (or in the
possession of any of Trubion’s agents and subcontractors, such as contract research organizations used by Trubion), to the extent Trubion has the right to access and provide to Wyeth such Product Data and Filings, regarding such regulatory
filings, each to the extent they relate to Licensed Products. Within thirty (30) days (or such later date as Wyeth may request) after the date of receipt of Wyeth’s reasonable request after consultation with the JDC, Trubion shall execute
and deliver a letter to the FDA or other Regulatory Authorities, in a form approved by Wyeth, transferring ownership to Wyeth of such regulatory filings, if any, filed in the name of Trubion that are related to Licensed Products. After such transfer
of ownership of regulatory filings relating to a Licensed Product, during the term of this Agreement all regulatory filings with the FDA or other Regulatory Authorities pertaining to such Licensed Product shall be made in the name of Wyeth, in
accordance with the terms of Section 4.3 below. 

  
 34 

	 	4.3.	 Regulatory Approvals. Wyeth shall have the sole authority to file, in its own name, at its sole expense,
all Regulatory Approval Applications for Licensed Products. Wyeth shall have the sole authority and responsibility for communicating with any Regulatory Authority regarding any Regulatory Approval Application, or any Regulatory Approval once
granted. To the extent necessary to satisfy applicable regulatory requirements with respect to the INDs for the clinical studies of CD20 Products described in Section 4.6, Wyeth hereby grants to Trubion a “Right of Reference,” as that term
is defined in 21 C.F.R. § 314.3(b), to any data Controlled by Wyeth that relates to any CD20 Products that are the subject of the clinical studies described in Section 4.6 hereof, and Wyeth shall provide a signed statement to this effect,
if requested by Trubion, in accordance with 21 C.F.R. § 314.50(g)(3). Copies of all Wyeth regulatory filings that relate to Trubion’s Development activities under this Agreement will be provided by Wyeth to Trubion upon request, subject to
reasonable resource and time constraints. 

  

	 	4.4.	 Regulatory Reporting. Wyeth shall be responsible for preparing and filing all reports required to be
filed in order to maintain any Regulatory Approvals granted for Licensed Products in the Territory, including, without limitation, adverse drug experience reports. To the extent Trubion has or receives any information regarding any adverse drug
experience which may be related to the use of any Licensed Product or to Licensed Product Development, Trubion shall promptly provide Wyeth with all such information in accordance with the Adverse Event Reporting and pharmacovigilance procedures set
forth in Exhibit 4.4 attached hereto (as may be amended from time to time upon written mutual agreement of the Parties). From time to time after the Effective Date, representatives from both Parties shall meet to review and revise or replace
such Adverse Event Reporting and pharmacovigilance procedures. 

  

	 	4.5.	 Progress Reports. 

 

	 	(a)	 Wyeth shall provide Trubion with confidential summary reports of its and its sublicensees’ Development
activities, on a Licensed Product-by-Licensed Product basis, on a quarterly basis, with respect to CD20 Products and HER2 Products, and on an annual basis, with respect
to Other Products. The form of the summary reports, and the type of information and the appropriate and reasonable level of detail to be included in such reports, shall be mutually and reasonably agreed by the Parties; provided that the
Parties agree that such reports shall include information regarding progress towards and achievement of any event set forth in Exhibit 5.3 attached hereto. 

  
 35 

	 	(b)	 Wyeth shall provide Trubion with confidential summary reports of its and its sublicensees’ CD20 Product
Commercialization activities on a quarterly basis after the First Commercial Sale of a CD20 Product. Beginning six (6) months prior to the anticipated First Commercial Sale of a CD20 Product, and thereafter on a semi-annual basis, Wyeth shall meet
with Trubion and provide updates on CD20 Product Commercialization activities. 

  

	 	(c)	 Wyeth shall provide Trubion with confidential summary reports of its and its sublicensees’ HER2 Product
Commercialization activities on a semi-annual basis after the First Commercial Sale of a HER2 Product. Beginning six (6) months prior to the anticipated First Commercial Sale of a HER2 Product, and thereafter on a semi-annual basis, Wyeth shall
meet with Trubion and provide updates on HER2 Product Commercialization activities. 

  

	 	(d)	 Wyeth shall provide Trubion with confidential summary reports of its and its sublicensees’ Other Product
Commercialization activities on an annual basis after the First Commercial Sale of an Other Product. Beginning six (6) months prior to the anticipated First Commercial Sale of an Other Product, and thereafter on an annual basis, Wyeth shall meet
with Trubion and provide updates on Other Product Commercialization activities. 

  

	 	(e)	 The meetings described in clauses (b) – (d) above shall be coordinated to occur at the same time, to the
extent practicable. 

  

	 	4.6.	 CD20 Product Development. Subject to Section 4.7 hereof, Trubion shall use its Commercially
Reasonable Efforts to conduct the following Development activities for CD20 Products: (a) Trubion shall continue the Phase I Clinical Studies and Phase IIa Clinical Studies of TRU-015 ongoing at the
Effective Date for treatment of rheumatoid arthritis until completion or termination of such studies, including the re-treatment periods of such studies; (b) Trubion shall initiate and perform the planned
Phase IIb Clinical Study of TRU-015 for treatment of rheumatoid arthritis through the completion or termination of such study; (c) Trubion shall continue the Phase I Clinical Study ongoing at the
Effective Date, and shall initiate and perform the planned Phase III Clinical Studies (or the appropriate subsequent clinical study) of TRU-015 for the treatment of inflammatory myositis through the completion
or termination of such studies; (d) Trubion 

  
 36 

 shall have responsibility for and shall perform the clinical studies for at least two
(2) additional Niche Indications selected by the Parties and set forth in the Development Plan; and (e) Trubion shall continue to perform the ongoing bioprocess development activities, and in each case
(a-e) such activities and responsibilities of Trubion shall be performed in accordance with the Development Plan. None of the clinical studies described in this Section 4.6 shall be terminated prior to
completion before discussion of such matter by the JDC. Trubion shall keep accurate records of its clinical study activities under this Section 4.6 in accordance with applicable laws and, upon reasonable request, shall provide Wyeth with access
to such records. Trubion shall maintain such records for a period of at least three (3) years after the end of the calendar year in which they were generated. The Development Plan shall provide that Trubion is responsible for conducting the clinical
trials for rheumatoid arthritis, inflammatory myositis and additional Niche Indications through the completion or termination of such clinical studies described above and shall contain a budget for such clinical trials. Trubion shall be solely
responsible for its internal FTE and other internal costs for such Development activities, but Wyeth shall reimburse Trubion for all out-of-pocket costs incurred by
Trubion in connection with the foregoing Development activities in accordance with the budget contained in the Development Plan (which shall include, without limitation, all expenses paid to one or more contract research organizations for such
Development activities). Trubion shall provide to Wyeth, on or before the first day of each Calendar Quarter, a forecast of such out-of-pocket costs (by major expense
category, on an accrual basis) reimbursable under this Section 4.6 that Trubion expects to incur during such Calendar Quarter and the subsequent three (3) Calendar Quarters, in each case shown by month. Reimbursement to be made to Trubion
by Wyeth pursuant to this Section 4.6 will be made pursuant to invoices submitted by Trubion to Wyeth no more often than once with respect to any Calendar Quarter, within forty-five (45) days of the end of such Calendar Quarter. Payment shall
be due within forty-five (45) days after Wyeth receives such an invoice from Trubion. Each invoice must be accompanied by supporting documentation sufficiently demonstrating the expense so incurred (such as receipts for out-of-pocket expenses). The provisions of Section 3.6.3 shall apply to the expenses reimbursable by Wyeth under this Section 4.6 in the same manner as they apply to
expenses reimbursable under Section 3.6.1. 
  

	 	4.7.	 Joint Development Committee. Within thirty (30) days of the Effective Date, Wyeth and
Trubion shall establish a CD20 Product Joint Development Committee (the “JDC”), comprised of appropriate representatives of both Parties, to review and provide input to Wyeth regarding CD20 Product Development in the Territory, including
the strategic direction of the overall CD20 Product Development program. Wyeth shall consider in good faith any of Trubion JDC members’ comments and recommendations regarding CD20 Product Development, 

  
 37 

 but Wyeth shall have final decision-making authority with respect to how the Parties proceed
with CD20 Product Development, subject to Wyeth’s obligations under Section 4.1 in connection therewith. If Trubion disagrees with an action or decision by the JDC, Trubion may express its concerns through good faith discussions between
the Executive Officers of Trubion and Wyeth, with Wyeth Research’s President having the final decision-making authority with respect to such matter. For the avoidance of doubt, the JDC may not impose different or greater CD20 Product
Development obligations on Trubion than those specified in Section 4.6. 
  

	 	4.8.	 Joint Project Team; Development Plan. Trubion and Wyeth shall form a Joint Project Team
(“JPT”) comprised of appropriate representatives of both Parties to plan and implement the CD20 Product Development activities in accordance with the Development Plan. The JPT shall report to the JDC. If the JPT cannot promptly resolve a
disagreement or a voting deadlock regarding the CD20 Product Development activities, the matter shall be brought before the JDC for resolution. Wyeth shall prepare the Development Plan with input and advice from Trubion through the JPT. The
Development Plan will define each Party’s roles and responsibilities, provide a mechanism to coordinate each Party’s and/or joint activities, and provide a process for monthly meetings of the JPT to monitor and report on all activities of
the Parties conducted under the Development Plan. The Development Plan shall not impose different or greater CD20 Product Development obligations on Trubion than those specified in Section 4.6. The Development Plan shall be updated annually by
the JPT. 

  

	 	4.9.	 Manufacturing. Wyeth shall have the exclusive right to Manufacture Licensed Products itself or through
one or more Third Parties selected by Wyeth; provided, however, that Trubion shall use its Commercially Reasonable Efforts to Manufacture and supply Wyeth with its requirements of the TRU-015 Product in
accordance with the Development Plan under Trubion’s existing contract Manufacturing arrangements for use in pre-clinical studies and clinical trials (“Clinical Study Supplies”); provided
that Trubion cannot guarantee as of the Effective Date that it will be able to Manufacture and supply such requirements. Wyeth shall reimburse Trubion for its direct
out-of-pocket cost of Clinical Study Supplies, including, without limitation,
out-of-pocket expenses incurred by Trubion prior to the Effective Date that are directly related to the Manufacture, testing and release of Clinical Study Supplies to be
used after the Effective Date (such pre-Effective Date out-of-pocket expenses not to exceed Three Million Dollars ($3,000,000)).
Reimbursement of such pre-Effective Date expenses shall be due within thirty (30) days after the first patient is dosed in the first Phase IIb Clinical Study for rheumatoid arthritis using such Clinical
Study Supplies. Upon Wyeth’s written request, Trubion shall provide reasonable assistance to Wyeth, until the first cGMP batch of TRU-015 Product is Manufactured in a Wyeth facility (or the facility of a
Third Party designated by Wyeth), in support and facilitation of Wyeth’s efforts 

  
 38 

 to Manufacture TRU-015 Products and to secure
appropriate TRU-015 Product Manufacturing arrangements with Third Parties. Such assistance shall be at no cost to Wyeth; provided that Wyeth shall reimburse Trubion for all of its reasonable out-of-pocket expenses related thereto. If applicable, upon Wyeth’s written request, Trubion shall assign or otherwise transfer to Wyeth (to the extent allowable under
such agreements) its TRU-015 Product Manufacturing agreements with Third Parties. 
  

	 	4.10.	 Commercialization. Subject to the terms and conditions of this Agreement, Wyeth shall have the
sole authority and the exclusive right to Commercialize Licensed Products itself or through one or more Third Parties selected by Wyeth and shall have sole authority and responsibility in all matters relating to the Commercialization of Licensed
Products. Wyeth shall use Commercially Reasonable Efforts to Commercialize Licensed Products in the Territory in each country where Wyeth has obtained Regulatory Approval for such Licensed Product(s) and for each indication of such Licensed
Product(s) for which Regulatory Approval has been obtained in such country. 

  

	 	4.11.	 Co-Promotion Option. Subject to the foregoing, in the event of a
BLA filing with the FDA for Regulatory Approval of a CD20 Product for a Niche Indication in the United States, Trubion shall have the option to Co-Promote the CD20 Product in the United States for such
Niche Indication in accordance with Wyeth’s marketing plan for up to five (5) years after the First Commercial Sale of the first CD20 Product for any Niche Indication in the United States (the
“Co-Promotion Period”). The Trubion Co-Promotion option shall be exercisable by Trubion giving written notice to Wyeth no later than forty-five (45) days
after the date of the first BLA filing with the FDA for the first Niche Indication for the first CD20 Product (or such longer time as the Parties may mutually agree). Promptly after Trubion’s exercise of such option, the Parties shall
negotiate, in good faith, a definitive Co-Promotion Agreement, which shall require Trubion and Wyeth to use Commercially Reasonable Efforts to Co-Promote such CD20
Product. Such Co-Promotion Agreement shall contain customary provisions relating to relative sales force efforts, responsibility for sales calls, sales force training, promotional materials and samples,
detailing and the number and qualifications of sales force personnel (including medical science liaisons) that will be devoted to such Co-Promotion activities. The Parties hereby agree, inter alia, that
such Co-Promotion Agreement, and Wyeth’s marketing plan for such CD20 Product, shall provide (a) Trubion’s sales force with a meaningful role in the Commercialization of such CD20 Product;
(b) that Wyeth shall provide CD20 Product-related sales training to Trubion’s sales force, at no cost to Trubion; and (c) that Trubion’s sales force shall use CD20 Product promotional materials and samples, to be provided by
Wyeth at no cost, in connection with their sales efforts. As compensation for sales force support provided by Trubion in connection with such Co-Promotion, Wyeth shall pay Trubion a fixed fee (to be set

  
 39 

 forth in the definitive Co-Promotion Agreement) for
each Product sales detail performed by members of Trubion’s sales force in accordance with Wyeth’s marketing plan for such CD20 Product. Trubion will not have the right to contract out for or otherwise delegate to any Third Party any
responsibility for such sales force support. Trubion’s sales force activities shall be conducted in accordance with Wyeth’s policies and the marketing and promotion plan for the CD20 Product. 

 

	 	4.12.	 Co-Promotion Committee. If Trubion exercises its Co-Promotion option with respect to a CD20 Product in accordance with Section 4.11 hereof, a Co-Promotion Committee shall be formed by the Parties within thirty
(30) days after such exercise. The Co-Promotion Committee shall oversee all aspects of Co-Promotion-related activities and reasonably relevant aspects of Commercialization of such CD20 Product during the Co-Promotion Period, and shall include Trubion’s Chief Executive Officer and Wyeth’s Executive Vice President and General Manager, Wyeth BioPharma. 

 

	 	4.13.	 Co-Branding. To the extent allowed by applicable law, all
product labeling for CD20 Products shall include both Parties’ names, which shall be of similar size and prominence to the extent practicable (except (i) with respect to labeling of vials or other components of a CD20 Product that do not
include either Party’s name or (ii) with respect to labeling of diluent or other components packaged together with the CD20 Product that do not customarily contain another Person’s name). 

 

	 	4.14.	 Marking. All Licensed Products shall be marked with the patent numbers of issued patents within Trubion
Patent Rights and Wyeth Patent Rights that cover such Licensed Products, to the extent practicable and permitted by law in countries in which such markings have notice value against infringers of patents. 

 

	5.	 CONSIDERATION. 

 

	 	5.1.	 Initial Research and Development Expense Payment. In consideration of Trubion’s agreement to
conduct the Research Program and to participate on the JRC and JDC, Wyeth shall pay to Trubion Forty Million Dollars ($40,000,000.00) within ten (10) days after the Effective Date, which payment shall be
non-refundable and non-creditable. 

  

	 	5.2.	 Equity. Wyeth shall purchase from Trubion common stock of Trubion at such time, in such amounts and for
such price as specified in the Stock Purchase Agreement, attached hereto as Exhibit 5.2A. Concurrent with the execution of the Stock Purchase Agreement, the Parties shall enter into an amendment of Trubion’s Amended and Restated Investor
Rights Agreement, attached hereto as Exhibit 5.2B. 

  
 40 

	 	5.3.	 Additional Research and Development Expense Payments. In further consideration of Trubion’s
contributions under the Research Program and the Development Program, as provided in Articles 3 and 4 above, Wyeth shall pay to Trubion the payments specified in Exhibit 5.3 attached hereto (each an “Additional Research and Development
Expense Payment”) in the amounts and at such times as specified in Exhibit 5.3. Wyeth shall notify Trubion promptly upon the achievement of each event specified in Exhibit 5.3. 

 

	 	5.4.	 Royalties. 

  

	 	5.4.1.	 Licensed Product Royalties. In consideration for the licenses granted to Wyeth under Section 2.1
hereof, and in addition to those payments required to be made by Wyeth pursuant to Section 5.1, Section 5.2 and Section 5.3, Wyeth shall pay to Trubion royalties during the Royalty Period as set forth in Sections 5.4.2, 5.4.3 and
5.4.4 below, subject to the adjustments provided in Section 5.4.6 below. 

  

	 	5.4.2.	 CD20 Product Royalties. 

 

	 	(a)	 Except as provided in Sections 5.4.2(b) and 5.4.2(c) below, Wyeth shall pay to Trubion royalties in the amount
of the Marginal Royalty Rates (set forth below) of the aggregate Net Sales collectively obtained by Wyeth and its sublicensees from the sale of CD20 Products in the Territory during each calendar year in the applicable Royalty Period:

  

					
	 	  	Marginal Royalty Rate	 
	 	  	(% of the Applicable Portion	 
	 Annual Net Sales Level
	  	of Annual Net Sales)	 
	 Less than $500 million
	  	 	10.0	% 
	 From $500 million up to $1.0 billion
	  	 	12.5	% 
	 From $1.0 billion up to $1.5 billion
	  	 	15.0	% 
	 From $1.5 billion up to $2.0 billion
	  	 	17.5	% 
	 Greater than $2.0 billion
	  	 	20.0	% 

 Each Marginal Royalty Rate set forth in the table above shall apply only to that portion of the annual Net
Sales that falls within the indicated range. By way of example only, if the aggregate Net Sales of CD20 Products during a calendar year equaled $1.2 billion, the total royalty for CD20 Products during such year would equal the specified
Marginal Royalty Rate (10.0%) of the first five hundred million dollars ($500,000,000) of Net Sales, plus the specified Marginal Royalty Rate (12.5%) of the next five hundred million dollars ($500,000,000) of Net Sales, plus the
specified Marginal Royalty Rate (15.0%) of the remaining two hundred million dollars ($200,000,000) of Net Sales (that is, $50 million + $62.5 million + $30 million, which would equal $142.5 million). 

  
 41 

 For purposes of this Section 5.4.2, the “CD20 Effective Royalty Rate” for a
particular time period shall mean the weighted average, expressed as a percentage, of the Marginal Royalty Rates that would apply under the provisions of this Section 5.4.2(a) to the aggregate CD20 Product Net Sales in the Territory during such
time period (without regard, for these purposes, to any adjustments made under Sections 5.4.2(b) or 5.4.2(c)). By way of example only, if the aggregate Net Sales of CD20 Products in the Territory during a calendar year equaled $1.2 billion, the
CD20 Effective Royalty Rate for such calendar year would be calculated as follows: ((10.0% of $500 million) plus (12.5% of $500 million) plus (15.0% of $200 million)) divided by $1.2 billion, expressed as a percentage,
which would equal 11.875%. By way of further example only, if the aggregate Net Sales of CD20 Products in the Territory during each of the four Calendar Quarters of such calendar year were $250 million, $275 million, $325 million and
$350 million, respectively (for a total of $1.2 billion in such calendar year), the CD20 Effective Royalty Rates for each of the four Calendar Quarters would be 10%, 10.227%, 12.5% and 13.929%, respectively. 

 

	 	(b)	 Subject to the provisions of Section 5.4.2(c) below, in the event that, at any time during the term of the
Product License, no issued Valid Claim is included within the Trubion Patent Rights in a country where a CD20 Product is sold (which claim, but for the licenses granted hereunder to Wyeth, would be infringed by Wyeth’s or its sublicensees’
Manufacture, use, sale, offer for sale or import of such CD20 Product in such country); Wyeth shall pay to Trubion royalties with respect to such CD20 Product in such country during such time period, in lieu of the royalties described in
Section 5.4.2(a), equal to the following amount: (i) the CD20 Effective Royalty Rate of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such CD20 Product in such country during such time period minus
(ii) two percent (2%) of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such CD20 Product in such country during such time period. By way of example only, 

  
 42 

 if the aggregate Net Sales of such a CD20 Product in such country during the relevant time
period were $100,000,000 and the CD20 Effective Royalty Rate (based on Net Sales of CD20 Products throughout the Territory) for such time period were 11.875%, the royalties payable under this Section 5.4.2(b) on Net Sales in such country would
equal (i) 11.875% of $100,000,000, (or $11,875,000), minus (ii) 2% of $100,000,000, (or $2,000,000), which would equal $9,875,000. By way of further example only, if the aggregate Net Sales of such a CD20 Product in such country during the
relevant time period were $30,000,000 and the CD20 Effective Royalty Rate (based on Net Sales of CD20 Products throughout the Territory) for such time period were 13.929%, the royalties payable under this Section 5.4.2(b) on Net Sales in such
country would equal (i) 13.929% of $30,000,000, (or $4,178,700), minus (ii) 2% of $30,000,000, (or $600,000), which would equal $3,578,700. 
  

	 	(c)	 In the event that at any time during the term of the Product License: (i) no issued Valid Claim is
included within the Trubion Patent Rights in a country where a CD20 Product is sold (which claim, but for the licenses granted hereunder to Wyeth, would be infringed by Wyeth’s or its sublicensees’ Manufacture, use, sale, offer for sale or
import of such CD20 Product in such country), (ii) a product is sold by a Third Party in such country, which product would, if sold by such Third Party in the United States, infringe an issued Valid Claim included within the Trubion Patent Rights in
the United States, and (iii) such product sold by the Third Party has a ten percent (10%) or greater unit market share in such country (where the market is defined as the sum of the unit sales of such CD20 Product and of the product described
in clause (ii)), Wyeth shall pay to Trubion royalties with respect to such CD20 Product in such country during such time period, in lieu of the royalties described in Section 5.4.2(a) and Section 5.4.2(b), equal to the following amount:
(i) fifty percent (50%) of (ii) the CD20 Effective Royalty Rate of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such CD20 Product in such country during such time period. By way of example only, if the
aggregate Net Sales of such a CD20 Product in such country during the relevant time period were $100,000,000 and the CD20 Effective Royalty Rate for such time period were 11.875%, the royalties payable under this Section 5.4.2(c) would equal
(i) 50% of (ii) 11.875% of $100,000,000, (or $11,875,000), which would equal $5,937,500. 

  
 43 

	 	5.4.3.	 HER2 Product Royalties. 

 

	 	(a)	 Except as provided in Sections 5.4.3(b) and 5.4.3(c) below, Wyeth shall pay to Trubion royalties in the amount
of the Marginal Royalty Rates (set forth below) of the aggregate Net Sales collectively obtained by Wyeth and its sublicensees from the sale of each HER2 Product in the Territory during each calendar year in the applicable Royalty Period:

  

					
	 	  	Marginal Royalty Rate	 
	 	  	(% of the Applicable Portion	 
	 Annual Net Sales Level
	  	of Annual Net Sales)	 
	 Less than $500 million
	  	 	7.5	% 
	 From $500 million up to $1.0 billion
	  	 	10.0	% 
	 From $1.0 billion up to $1.5 billion
	  	 	12.5	% 
	 From $1.5 billion up to $2.0 billion
	  	 	15.0	% 
	 Greater than $2.0 billion
	  	 	17.5	% 

 Each Marginal Royalty Rate set forth in the table above shall apply only to that portion of the annual Net
Sales for a particular HER2 Product that falls within the indicated range. By way of example only, if the aggregate Net Sales of a HER2 Product during a calendar year equaled $1.2 billion, the total royalty for such HER2 Product during such
calendar year would equal the specified Marginal Royalty Rate (7.5%) of the first five hundred million dollars ($500,000,000) of Net Sales, plus the specified Marginal Royalty Rate (10.0%) of the next five hundred million dollars
($500,000,000) of Net Sales, plus the specified Marginal Royalty Rate (12.5%) of the remaining two hundred million dollars ($200,000,000) of Net Sales (that is, $37.5 million + $50 million + $25 million, which would equal $112.5
million). 
 For purposes of this Section 5.4.3, the “HER2 Effective Royalty Rate” for a particular time period for a
particular HER2 Product shall mean the weighted average, expressed as a percentage, of the Marginal Royalty Rates that would apply under the provisions of this Section 5.4.3(a) to the Net Sales in the Territory of such HER2 Product during such
time period (without regard, for these purposes, to any adjustments made under Sections 5.4.3(b) or 5.4.3(c)). By way of example only, if the Net Sales of a HER2 Product in 

  
 44 

 the Territory during a calendar year equaled $1.2 billion, the HER2 Effective Royalty
Rate for such calendar year for such HER2 Product would be calculated as follows: ((7.5% of $500 million) plus (10.0% of $500 million) plus (12.5% of $200 million)) divided by $1.2 billion, expressed as a percentage, which
would equal 9.375%. By way of further example only, if the Net Sales of such HER2 Product in the Territory during each of the four Calendar Quarters of such calendar year were $250 million, $275 million, $325 million, and
$350 million, respectively (for a total of $1.2 billion in such calendar year), the HER2 Effective Royalty Rates for each of the four Calendar Quarters would be 7.5%, 7.727%, 10% and 11.429%, respectively. 

 

	 	(b)	 Subject to the provisions of Section 5.4.3(c) below, in the event that, at any time during the term of the
Product License, no issued Valid Claim is included within the Trubion Patent Rights in a country where a HER2 Product is sold (which claim, but for the licenses granted hereunder to Wyeth, would be infringed by Wyeth’s or its sublicensees’
Manufacture, use, sale, offer for sale or import of such HER2 Product in such country), Wyeth shall pay to Trubion royalties with respect to such HER2 Product in such country during such time period, in lieu of the royalties described in
Section 5.4.3(a), equal to the following amount: (i) the HER2 Effective Royalty Rate for such HER2 Product of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such HER2 Product in such country during such
time period minus (ii) two percent (2%) of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such HER2 Product in such country during such time period. By way of example only, if the aggregate Net Sales of
such a HER2 Product in such country during the relevant time period were $100,000,000 and the HER2 Effective Royalty Rate (based on Net Sales of such HER2 Product throughout the Territory) for such time period for such HER2 Product were 9.375%, the
royalties payable under this Section 5.4.3(b) on Net Sales in such country would equal (i) 9.375% of $100,000,000, (or $9,375,000), minus (ii) 2% of $100,000,000, (or $2,000,000), which would equal $7,375,000. By way of further example
only, if the Net Sales of such HER2 Product in such country during the relevant time period were $30,000,000 and the HER2 Effective Royalty Rate (based on Net Sales of such HER2 Product throughout the Territory) for such time period were 11.429%,
the royalties payable under this Section 5.4.3(b) on Net Sales in such country would equal (i) 11.429% of $30,000,000, (or $3,428,700), minus (ii) 2% of $30,000,000, (or $600,000), which would equal $2,828,700. 

  
 45 

	 	(c)	 In the event that at any time during the term of the Product License: (i) no issued Valid Claim is
included within the Trubion Patent Rights in any country where a HER2 Product is sold (which claim, but for the licenses granted hereunder to Wyeth, would be infringed by Wyeth’s or its sublicensees’ Manufacture, use, sale, offer for sale
or import of such HER2 Product in such country), (ii) a product is sold by a Third Party in such country, which product would, if sold by such Third Party in the United States, infringe an issued Valid Claim included within the Trubion Patent Rights
in the United States, and (iii) such product sold by a Third Party has a ten percent (10%) or greater unit market share in such country (where the market is defined as the sum of the unit sales of such HER2 Product and of the product described
in clause (ii)), Wyeth shall pay to Trubion royalties with respect to such HER2 Product in such country during such time period, in lieu of the royalties described in Section 5.4.3(a) and Section 5.4.3(b), equal to the following amount:
(i) fifty percent (50%) of (ii) the HER2 Effective Royalty Rate for such HER2 Product of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such HER2 Product in such country during such time period. By way of
example only, if the aggregate Net Sales of such a HER2 Product in such country during the relevant time period were $100,000,000 and the HER2 Effective Royalty Rate for such time period for such HER2 Product were 9.375%, the royalties payable under
this Section 5.4.3(c) on Net Sales in such country would equal (i) 50% of (ii) 9.375% of $100,000,000, (or $9,375,000), which would equal $4,687,500. By way of further example only, if the Net Sales of such HER2 Product in such country during
the relevant time period were $30,000,000 and the HER2 Effective Royalty Rate (based on Net Sales of such HER2 Product throughout the Territory) for such time period were 11.429%, the royalties payable under this Section 5.4.3(c) on Net Sales
in such country would equal (i) 50% multiplied by (ii) 11.429% of $30,000,000, (or $3,428,700), which would equal $1,714,350. 

  
 46 

	 	5.4.4.	 Other Product Royalties. 

 

	 	(a)	 Except as provided in Sections 5.4.4(b) and 5.4.4(c) below, Wyeth shall pay Trubion a royalty of five percent
(5.0%) of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of each Other Product in the Territory during each calendar year in the applicable Royalty Period. 

 

	 	(b)	 Subject to the provisions of Section 5.4.4(c) below, in the event that, at any time during the term
of the Product License, no issued Valid Claim is included within the Trubion Patent Rights in a country where an Other Product is sold (which claim, but for the licenses granted hereunder to Wyeth, would be infringed by Wyeth’s or its
sublicensees’ Manufacture, use, sale, offer for sale or import of such Other Product in such country), Wyeth shall pay to Trubion, with respect to such Other Product in such country during such time period, in lieu of the royalty described in
Section 5.4.4(a), a royalty of four percent (4.0%) of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such Other Product in such country during such time period. 

 

	 	(c)	 In the event that at any time during the term of the Product License: (i) no issued Valid Claim is
included within the Trubion Patent Rights in any country where an Other Product is sold (which claim, but for the licenses granted hereunder to Wyeth, would be infringed by Wyeth’s or its sublicensees’ Manufacture, use, sale, offer for
sale or import of such Other Product in such country), (ii) a product is sold by a Third Party in such country, which product would, if sold by such Third Party in the United States, infringe an issued Valid Claim included within the Trubion Patent
Rights in the United States, and (iii) such product sold by a Third Party has a ten percent (10%) or greater unit market share in such country (where the market is defined as the sum of the unit sales of such Other Product and of the product
described in clause (ii)), Wyeth shall pay to Trubion, with respect to such Other Product in such country during such time period, in lieu of the royalties described in Section 5.4.4(a) and Section 5.4.4(b), a royalty of two and one half
percent (2.5%) of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such Other Product in such country during such time period. 

  
 47 

	 	5.4.5.	 Expiration of Royalty Period. After the expiration of the Royalty Period for any Licensed Product in any
country in the Territory, no further royalties shall be payable in respect of sales of such Licensed Product in such country and thereafter the licenses granted to Wyeth under Section 2.1 with respect to such Licensed Product in such country
shall be fully paid-up, perpetual, irrevocable, royalty-free, exclusive licenses. 

  

	 	5.4.6.	 Royalty Adjustments. 

 

	 	(a)	 Certain Third Party Agreements. On a
country-by-country basis in a given calendar year, Wyeth shall deduct from CD20 Product royalties otherwise payable to Trubion under Section 5.4.2 fifty percent
(50%) of the aggregate amount of royalties actually paid to Third Parties under Additional Third Party Licenses with respect to the Development, Manufacture or Commercialization of CD20 Products in such country in such calendar year;
provided, however, that (i) the amount of such deduction shall not exceed twenty percent (20%) of the amount of the CD20 Product royalties otherwise payable to Trubion under Section 5.4.2 in a given calendar year and
(ii) such deduction shall not have the effect, under any circumstances, of reducing the CD20 Product royalties payable under Section 5.4.2 below ten percent (10%) of the aggregate Net Sales obtained by Wyeth and its sublicensees from the
sale of CD20 Products in such country in a given calendar year (before taking into account the operation of Sections 5.4.2(b) and 5.4.2(c)). On a country-by-country
basis in a given calendar year, Wyeth shall deduct from HER2 Product royalties otherwise payable to Trubion under Section 5.4.3 fifty percent (50%) of the aggregate amount of royalties actually paid to Third Parties under Additional Third Party
Licenses with respect to the Development, Manufacture or Commercialization of such HER2 Product in such country in such calendar year; provided, however, that (i) the amount of such deduction shall not exceed twenty percent (20%)
of the amount of the HER2 Product royalties otherwise payable to Trubion under Section 5.4.3 in a given calendar year and (ii) such deduction shall not have the effect, under any circumstances, of reducing the HER2 Product royalties
payable under Section 5.4.3 below seven and one-half percent (7.5%) of the aggregate Net Sales obtained by Wyeth and its sublicensees from the sale of such HER2 Product in such country in a given calendar
year (before taking into account the operation of Sections 5.4.3(b) and 5.4.3(c)). Wyeth shall not make any deductions under this Section 5.4.6(a) from royalties payable to Trubion under

  
 48 

	 	
Section 5.4.4 on Net Sales of Other Products. Wyeth shall be solely responsible for all (and shall bear entirely at its own expense) non-royalty costs
(i.e., costs other than those paid as a percentage of sales) of any Additional Third Party Licenses (including, without limitation, upfront license fees and milestone payments, if any). Trubion shall be solely responsible for all (and
shall bear entirely at its own expense) royalties and non-royalty costs of any Trubion Additional Third Party Licenses (including, without limitation, upfront license fees and milestone payments, if any).

  

	 	(b)	 Other Third Party Agreements. Wyeth shall be solely responsible for all payment obligations related to
the Conjugates, Licensed Products and Wyeth Technology under its licenses and other agreements with Third Parties that are in effect as of the Effective Date, and no adjustment to the royalties payable by Wyeth under Section 5.4.1 shall be made
on account of any such obligations. Trubion shall be solely responsible for all payment obligations related to the Trubion Technology under its licenses and other agreements with Third Parties that are in effect as of the Effective Date including,
without limitation, those obligations arising under the Trubion Third Party Agreements. 

  

	 	5.5.	 Reports and Payments. 

 

	 	5.5.1.	 Cumulative Royalties. The obligation to pay royalties under Section 5.4 of this Agreement shall be
imposed only once with respect to a single unit of a Licensed Product, regardless of how many Valid Claims included within the Trubion Technology would, but for this Agreement, be infringed by the Manufacture, use, import, offer for sale or sale of
such Licensed Product in the countr(y)ies of such Manufacture, use or sale. For the avoidance of doubt, if a single Licensed Product is both a CD20 Product and an Other Product, such Licensed Product shall be deemed to be a CD20 Product for purposes
of the royalty obligations under Section 5.4. If a single Licensed Product is both a HER2 Product and an Other Product, such Licensed Product shall be deemed to be a HER2 Product for purposes of the royalty obligations under Section 5.4.

  
 49 

	 	5.5.2.	 Royalty Statements and Payments. Within sixty (60) days after the end of each Calendar Quarter,
Wyeth shall deliver to Trubion a report setting forth for such Calendar Quarter the following information, on a Licensed Product-by-Licensed Product and country-by-country basis: (a) the gross sales amount (by Wyeth and its sublicensees) for each category of Licensed Product sold in the United States and the number of units of Licensed Product sold in the
United States and other countries in the Territory, on a country-by-country basis; (b) the Net Sales for each Licensed Product; (c) any adjustments (including
the basis therefor) made pursuant to Sections 5.4.2(b), 5.4.2(c), 5.4.3(b), 5.4.3(c), 5.4.4(b), 5.4.4(c) or 5.4.6(a) to the royalty amount payable for the sale of each Licensed Product, the applicable Marginal Royalty Rates and the CD20 Effective
Royalty Rate or HER2 Effective Royalty Rate (as the case may be) payable on the Net Sales, and (d) the royalty amount due hereunder for the sale of each Licensed Product. No such reports shall be due for any Licensed Product before the First
Commercial Sale of such Licensed Product. The total royalty due for the sale of Licensed Products during such Calendar Quarter shall be remitted at the time such report is made. 

 

	 	5.5.3.	 Taxes and Withholding. All payments due Trubion under this Agreement will be made without any
deduction or withholding for or on account of any tax unless such deduction or withholding is required by applicable laws or regulations to be assessed against Trubion. If Wyeth is so required to deduct or withhold, Wyeth will (a) promptly
notify Trubion of such requirement, (b) pay to the relevant authorities the full amount required to be deducted or withheld promptly upon the earlier of determining that such deduction or withholding is required or receiving notice that such
amount has been assessed against Trubion, (c) promptly forward to Trubion an official receipt (or certified copy) or other documentation reasonably acceptable to Trubion evidencing such payment to such authorities, and (d) otherwise
reasonably cooperate with Trubion in connection with Trubion’s attempts to obtain favorable tax treatment and credit therefor (where appropriate) in accordance with applicable laws. 

 

	 	5.5.4.	 Currency. All amounts payable and calculations hereunder shall be in United States Dollars. As
applicable, Net Sales and any royalty deductions shall be translated into United States dollars in accordance with Wyeth’s customary and usual translation procedures, consistently applied, which procedures are in accordance with Generally
Accepted Accounting Principles in the United States. 

  
 50 

	 	5.5.5.	 Additional Provisions Relating to Royalties. Trubion acknowledges and agrees that nothing in this
Agreement (including, without limitation, any exhibits or attachments hereto) shall be construed as representing an estimate or projection of either (a) the number of Licensed Products that will or may be successfully Developed or
Commercialized or (b) anticipated sales or the actual value of any Licensed Product and that the figures set forth in Section 5.4 or elsewhere in this Agreement or that have otherwise been discussed by the Parties are merely intended to
define Wyeth’s royalty obligations to Trubion in the event such sales performance is achieved. WYETH MAKES NO REPRESENTATION OR WARRANTY, EITHER EXPRESS OR IMPLIED, THAT IT WILL BE ABLE TO SUCCESSFULLY DEVELOP OR COMMERCIALIZE ANY LICENSED
PRODUCT OR, IF COMMERCIALIZED, THAT IT WILL ACHIEVE ANY PARTICULAR SALES LEVEL OF SUCH LICENSED PRODUCT(S). 

  

	 	5.5.6.	 Interest on Past Due Payments. If either Party fails to pay any payment due under this Agreement on or
before the date such payment is due, as provided in this Agreement, such late payment shall bear interest, to the extent permitted by applicable law, at the average one-month London Inter-Bank Offering Rate
(LIBOR) for the United States Dollar as reported from time to time in The Wall Street Journal, effective for the first date on which payment was delinquent and calculated on the number of days such payment is overdue or, if such rate is not
regularly published, as published in such source as the Parties agree. 

  

	 	5.6.	 Maintenance of Records; Audits. 

 

	 	5.6.1.	 Record Keeping. Wyeth shall keep accurate books and accounts of record in connection with the sale of
Licensed Products, in sufficient detail to permit accurate determination of all figures necessary for verification of royalties and other payments to be paid to Trubion hereunder. Wyeth shall keep accurate records of its activities under this
Agreement that relate to the events with respect to which Additional Research and Development Expense Payments may be made under Section 5.3 hereof. Wyeth shall maintain such records for a period of at least three (3) years after the end
of the calendar year in which they were generated. 

  

	 	5.6.2.	 Audits. Upon thirty (30) days prior written notice from Trubion, Wyeth shall permit an independent
certified public accounting firm of nationally recognized standing selected by Trubion and reasonably acceptable to Wyeth, to examine, at Trubion’s sole expense, the relevant books and records of Wyeth as may be reasonably necessary to verify
the accuracy of the reports submitted by Wyeth in accordance with Section 5.5 and the payment of royalties hereunder. An examination by Trubion 

  
 51 

	 	under this Section 5.6.2 shall occur not more than once in any calendar year and shall be limited to the pertinent books and records for any calendar year ending not more than three (3) years before the date
of the request. The accounting firm shall be provided access to such books and records at Wyeth’s facility(ies) where such books and records are normally kept and such examination shall be conducted during Wyeth’s normal business hours.
Wyeth may require the accounting firm to sign a standard non-disclosure agreement before providing the accounting firm access to Wyeth’s facilities or records. Upon completion of the audit, the accounting
firm shall provide both Wyeth and Trubion a written report disclosing whether the reports submitted by Wyeth are correct or incorrect, whether the royalties paid are correct or incorrect, and in each case, the specific details concerning any
discrepancies. No other information shall be provided to Trubion. 

	 	

	 	

	 	5.6.3.	 Underpayments/Overpayments. If such accounting firm concludes that additional royalties were due
to Trubion, Wyeth shall pay to Trubion the additional royalties within thirty (30) days of the date Wyeth receives such accountant’s written report so concluding. If such royalty underpayment exceeds ten percent (10%) of the royalties that
were to be paid to Trubion, Wyeth also shall reimburse Trubion for the out-of-pocket expenses incurred in conducting the audit. If such accounting firm concludes that
Wyeth overpaid royalties to Trubion, Trubion, within thirty (30) days of the date Trubion receives such account’s report so concluding, will refund such overpayments to Wyeth less the reasonable out-of-pocket costs incurred by Trubion in conducting the audit. 

	 	

	 	5.6.4.	 Confidentiality. All financial information of Wyeth which is subject to review under this
Section 5.6 shall be deemed to be Wyeth’s Confidential Information subject to the provisions of Article 7 hereof, and Trubion shall not disclose such Confidential Information to any Third Party or use such Confidential Information for any
purpose other than verifying payments to be made by Wyeth to Trubion hereunder; provided, however, that such Confidential Information may be disclosed by Trubion to Third Parties only to the extent necessary to enforce
Trubion’s rights under this Agreement. 

  

	6.	 INTELLECTUAL PROPERTY. 

 

	 	6.1.	 Inventions; Joint Patent Committee. 

  
 52 

	 	6.1.1.	 Ownership and Inventorship. A Party shall own all inventions and Know-How made solely by employees
of such Party, and shall jointly own with the other Party any invention, whether or not patentable, made jointly by employees of both Parties (a “Joint Invention”), all Joint Patent Rights directed thereto, and any Know-How made jointly by employees of both Parties (“Joint Know-How”). All determinations of inventorship under this Agreement shall be made in accordance with United States patent law. Each Party shall
disclose promptly in writing to the other any Joint Inventions and any candidate Joint Inventions of which it becomes aware. Subject to (a) the grant of licenses to Wyeth under Section 2.1 and to Trubion under Section 2.2, (b) the
exclusivity provisions of Section 2.3, and (c) the Parties’ other rights and obligations under this Agreement, each Party shall be free to exploit (including to research, Develop, Manufacture, Commercialize and enforce), either itself
or through the grant of licenses to Third Parties (which Third Party licenses are further sublicensable), Joint Patent Rights and Joint Know-How throughout the world without restriction, without the need to obtain further consent from the other
Party, and without payment of any compensation to the other Party. 

  

	 	6.1.2.	 SMIP Improvements. All SMIP Improvements made by Wyeth, whether independently or jointly with Trubion,
in the course of performing Wyeth’s obligations under this Agreement during the term of the Agreement (each, a “Covered SMIP Improvement”) shall be promptly disclosed by Wyeth to Trubion. Wyeth, subject to the rights and licenses
granted by Trubion to Wyeth hereunder, hereby grants to Trubion a worldwide, royalty-free (other than as expressly set forth in this Section 6.1.2), irrevocable, non-exclusive license (with the right to
sublicense), under Wyeth’s rights to such Covered SMIP Improvements, to practice, exploit and use such Covered SMIP Improvements in connection with the research, Manufacture, Development, Commercialization or use of SMIPs (but, to the extent
any Covered SMIP Improvement is directed to a complementarity determining region or any portion of a binding domain provided by Wyeth, Trubion shall not have a license from Wyeth hereunder to practice, exploit and use such Covered SMIP Improvement
in connection with the research, Manufacture, Development, Commercialization and use of proteins other than SMIPs); provided, however, for the avoidance of doubt, that the license granted to Trubion pursuant to this sentence shall not be
deemed to constitute or include a license with respect to any underlying Wyeth technology or any Wyeth Technology (including without limitation Manufacturing, delivery, formulation and conjugation technology) other than Wyeth’s rights to such
Covered SMIP Improvements. In the event, and to the extent, that 

  
 53 

	 	
Wyeth is obligated to pay a Third Party any royalties or other payments as a result of the licensing of a Covered SMIP Improvement to Trubion pursuant to this Section 6.1.2 or as a result of
Trubion’s or its sublicensees’ (excluding Wyeth’s) practice of such Covered SMIP improvement, the license by Wyeth to Trubion pursuant to this Section 6.1.2 with respect to such Covered SMIP Improvement shall be conditioned on
Trubion’s continuing obligation to pay Wyeth the amount of such royalties and other payments according to the terms of the applicable agreement between Wyeth and such Third Party. In the event that Trubion grants a sublicense to any Third Party
with respect to a Covered SMIP Improvement that is not a Joint Invention (but rather was invented solely by Wyeth), Trubion shall pay Wyeth a royalty of one and one half percent (1.5%) of the net sales by such sublicensee (or its affiliates or
sublicensees) of any product that incorporates such Covered SMIP Improvement. For purposes of the preceding sentence, “net sales” shall be defined in a manner substantially similar to the definition or “Net Sales” under this
Agreement. 

  

	 	6.1.3.	 Joint Patent Committee. 

 

	 	(a)	 Establishment; Meetings; Decisions. Within thirty (30) days after the
Effective Date, the Parties shall establish a Joint Patent Committee composed of at least one (1) representative from each Party with experience in the prosecution 01 biotechnology patents. The Joint Patent Committee will have such duties and
responsibilities as are expressly assigned to it under this Article 6. The Joint Patent Committee shall meet as soon as practicable after it is established by the Parties and, thereafter, at such additional times as the Parties deem appropriate, not
less frequently than quarterly. The meetings of the Joint Patent Committee shall alternate between the Parties’ business locations or as otherwise decided by the Joint Patent Committee; provided that Joint Patent Committee meetings may
be conducted in person, by telephone or by videoconference. Each Party shall use reasonable efforts to cause its representative(s) to attend each Joint Patent Committee meeting. Decisions of the Joint Patent Committee shall be made by unanimous
consent, with each Party having one vote. The Joint Patent Committee may act without a meeting if an action by unanimous written consent is signed by each committee member. If the Joint Patent Committee is unable to reach agreement on a matter for
which it has decision-malting authority pursuant to Section 6.1.3(b), 6.2.1(c) or 6.2.2(c), the matter may be 

  
 54 

	 	
referred, at the request of either Party, Tor resolution by outside patent counsel mutually selected by the Parties (wherein such outside patent counsel shall be knowledgeable and experienced in
the subject matter of the matter so referred), and such resolution shall be deemed the decision of the Joint Patent Committee. Unless otherwise agreed by the Parties, the patent counsel selected will not have served as primary outside IP counsel to
either Party prior to being selected to resolve the Joint Patent Committee disagreement. Unless otherwise agreed by the Parties, each Party shall be responsible for fifty percent (50%) of the amounts paid to such outside patent counsel in connection
with such resolution (including attorney’s fees and other costs). 

  

	 	(b)	 Category 1 Covered SMIP Improvements and Category 2 Covered SMIP Improvements. Without limiting
Wyeth’s obligation under Section 6.1.1 and Section 6.1.2 to disclose promptly to Trubion any inventions and candidate inventions made hereunder (including, without limitation, any Covered SMIP Improvements), each Party shall report on
a quarterly basis to the Joint Patent Committee whether any of its activities hereunder during the prior Calendar Quarter involved a new Covered SMIP Improvement. The Joint Patent Committee shall decide whether a given Covered SMIP Improvement
(i) is solely applicable to SMIP coding regions (a “Category 1 Covered SMIP Improvement”), or (ii) is not solely applicable to SMIP coding regions (a “Category 2 Covered SMlP Improvement”). As provided in greater detail
in Section 6.2.1(d) below, Trubion shall be responsible for preparation, filing, prosecution and maintenance of all Patent Rights directed to Category 1 Covered SMIP Improvements, and Wyeth shall be responsible for preparation, filing,
prosecution and maintenance of all Patent Rights directed to Category 2 Covered SMlP Improvements. 

  

	 	6.2.	 Patent Rights. 

 

	 	6.2.1.	 Filing, Prosecution and Maintenance of Patent Rights 

 

	 	(a)	 Trubion Patent Rights. 

 

	 	(i)	 Trubion Patent Rights. Trubion shall use its Commercially Reasonable Efforts to prepare, file, prosecute
and maintain, throughout the Territory, all 

  
 55 

	 	
of the Trubion Patent Rights, using patent counsel of Trubion’s choice; provided, however, that Trubion shall give Wyeth before filing a reasonable opportunity to review and comment
upon the text of any applications for Trubion Patent Rights to the extent related to any Licensed Product, any SMIPs directed against any Licensed Target, or the Development, Manufacture, use or Commercialization thereof (collectively,
“Product-Related Patent Rights”); and provided further, however, that patent counsel for patent applications for Product-Related Patent Rights that are prepared or filed on or after the Signing Date and that do not rely on the
priority date of a patent or patent application filed before the Signing Date will be mutually agreed upon by the Parties. Trubion shall reasonably consider and address Wyeth’s comments on patent applications included in Product-Related Patent
Rights. Trubion shall consult with Wyeth with respect to such patent applications, and shall supply Wyeth with a copy of such patent applications as filed, together with notice of each filing date and serial number. Trubion shall also keep Wyeth
advised of the status of prosecution of all such patent applications included in the Product-Related Patent Rights, and shall consult with Wyeth and provide Wyeth with a reasonable opportunity to comment on all correspondence received from and all
submissions to be made to any government patent office or authority with respect to any such patent application or patent. Trubion shall reasonably consider and address Wyeth’ s comments on such correspondence and submissions. Each Party shall
be responsible for fifty percent (50%) of Trubion’s out-of-pocket expenses incurred in connection with preparing, filing, prosecuting and maintaining such
Product-Related Patent Rights throughout the Territory, including, but not limited to, out-of-pocket expenses for inventorship determinations and inventorship disputes
(other than between the Parties); provided, however, that in the event Trubion grants a license(s) in a given country or countries to one or more Third Parties under any patent application or patent that is included in the Product-Related
Patent Rights, Wyeth shall be responsible for a pro rata portion, 

  
 56 

	 	
based on a total number of parties that includes Trubion, Wyeth and all Third Party licensees under such patent application or patent (e.g., if there are two (2) Third Party licensees
in addition to Wyeth and Trubion, then Wyeth shall be responsible for twenty-five percent (25%)), of Trubion’s out-of- pocket expenses incurred in a
given country in connection with preparing, filing, prosecuting and maintaining such patent application or patent. (As used in this Article 6, “out-of-pocket
expenses” shall be deemed to include, without limitation, reasonable attorneys’ fees.) Wyeth shall reimburse Trubion on a quarterly basis within forty-five (45) days of receiving an invoice accompanied by supporting documentation
demonstrating the out-of- pocket expenses so incurred. On an annual basis, during the last Calendar Quarter of each year, Trubion shall provide Wyeth with a good faith,
written estimate of the out-of-pocket expenses reimbursable by Wyeth under this Section 6.2.l(a) that Trubion expects to incur in the following calendar year. In addition, if Trubion elects not to file a patent application on Trubion Know-How
that, if filed, would be a Product-Related Patent Right, or to cease the prosecution and/or maintenance of any Product-Related Patent Rights, (except for abandonment of a patent application in favor of a patent application subsequently filed for
purposes of continuing the prosecution of Patent Rights claiming the inventions included in the abandoned patent application), Trubion shall provide Wyeth with written notice immediately upon the decision to not file or continue the prosecution of
such patent application or maintenance of such patent. In such event, Trubion shall permit Wyeth, at Wyeth’s sole discretion, to file and/or continue prosecution and/or maintenance of such Product-Related Patent Right on Trubion’s behalf
and at Wyeth’s own expense. If Wyeth elects to file or to continue such prosecution or maintenance, it shall notify Trubion in writing of such decision within ninety (90) days of receipt of Trubion’s written notice, in which case
Trubion shall assign to Wyeth such Product-Related Patent Right abandoned by Trubion and shall execute such documents and perform such acts, at Wyeth’s 

  
 57 

	 	
expense, as may be reasonably necessary to permit Wyeth to file, prosecute and/or maintain such Product-Related Patent Right. In the event that Wyeth files or continues the prosecution or
maintenance of any such Product-Related Patent Right pursuant to this Section 6.2.l(a), then Wyeth shall no longer be obligated to pay to Trubion any royalty payments that would be due solely with respect to such Product-Related Patent Right.

  

	 	(b)	 Wyeth Patent Rights. Subject to Section 6.2.l(d), and except with respect to Covered SMIP
Improvements, Wyeth, at its own expense, shall have the sole right, but not the obligation, to prepare, file, prosecute and maintain, throughout the Territory, all Wyeth Patent Rights, using patent counsel of Wyeth’s choice.

  

	 	(c)	 Joint Patent Rights. Subject to Section 6.2.l(d), in the event the Parties make any Joint Invention
(excluding a Covered SMIP Improvement), the Joint Patent Committee shall promptly meet to discuss and determine whether to seek patent protection thereon. If the Joint Patent Committee decides to seek patent protection on such Joint Invention, then
Wyeth shall have the primary obligation to prepare, file, prosecute and maintain any corresponding Joint Patent Rights throughout the Territory using patent counsel mutually agreeable to the Parties, such agreement not to be unreasonably withheld.
Wyeth shall give Trubion a reasonable opportunity to review and comment on the text of any patent application with respect to such Joint Patent Right before filing, shall consult with Trubion with respect thereto, shall reasonably consider and
address any of Trubion’s comments, and shall supply Trubion with a copy of each such patent application as filed, together with notice of its filing date and serial number. Wyeth shall keep Trubion advised of the status of the actual and
prospective patent filings (including, without limitation, the grant of any Joint Patent Rights), shall provide Trubion with a reasonable opportunity to comment on all correspondence received from and all proposed submissions to be made to any
government patent office or authority related to the filing, prosecution and maintenance of such patent filings, shall consult with Trubion with respect thereto, and shall reasonably consider and address any or ‘Trubion’s comments on such
correspondence and submissions. Trubion shall reimburse Wyeth for fifty percent (50%) of the out-of-pocket expenses incurred by

  
 58 

	 	
Wyeth in connection with preparing, filing, prosecuting and maintaining such Joint Patent Rights (other than
out-of-pocket expenses for inventorship determinations and inventorship disputes), which reimbursement will be made within forty-five (45) days of receiving
invoices, such invoices to be submitted by Wyeth no more often than once per Calendar Quarter and to be accompanied by supporting documentation demonstrating and detailing the expenses so incurred. On an annual basis, during the last Calendar
Quarter of each year, Wyeth shall provide Trubion with a good faith, written estimate of the out-of-pocket expenses reimbursable by Trubion under this Section 6.2.1
(c) that Wyeth expects to incur in the following calendar year. If Wyeth elects not to file a patent application on any such Joint Patent Rights, or to cease the prosecution and/or maintenance of any such Joint Patent Rights (except for abandonment
of a patent application in favor of a patent application subsequently filed for purposes of continuing the prosecution of Patent Rights claiming the inventions included in the abandoned patent application), Wyeth shall provide Trubion with written
notice immediately upon the decision to not file or continue the prosecution of such patent application or maintenance of such patent. In such event, Wyeth shall permit Trubion, at Trubion’s sole discretion, to file and/or continue prosecution
and/or maintenance of such Joint Patent Rights at Trubion’s own expense. If Trubion elects to continue such prosecution or maintenance, it shall notify Wyeth in writing of such decision within ninety (90) days of receipt of Wyeth’s
written notice, in which case, Wyeth shall assign to Trubion such Joint Patent Rights abandoned by Wyeth and shall execute such documents and perform such acts, at Trubion’s expense, as may be reasonably necessary to permit Trubion to file,
prosecute and/or maintain such Joint Patent Rights. 

  

	 	(d)	 Category 1 and Category 2 Covered SMIP Improvements. 

 

	 	(i)	 Category 1 Covered SMIP Improvements. In the event that Wyeth makes any Category 1 Covered SMIP
Improvement (whether it is an invention solely by Wyeth or a Joint Invention), Trubion shall have the first right and primary obligation to prepare, file, prosecute and maintain any Patent Rights covering such Category 1 Covered SMlP Improvement,
using patent counsel mutually agreeable to the Parties, such 

  
 59 

	 	
agreement not to be unreasonably withheld. Trubion shall give Wyeth a reasonable opportunity to review and comment on the text of any patent application with respect to such Category 1 Covered
SMIP Improvement before filing, shall consult with Wyeth with respect thereto, shall reasonably consider and address any of Wyeth’s comments, and shall supply Wyeth with a copy of the patent application as filed, together with notice of its
filing date and serial number. Trubion shall keep Wyeth advised of the status of the actual and prospective patent filings (including, without limitation, the grant of any Patent Rights covering such Category 1 Covered SMIP Improvements), shall
provide Wyeth with a reasonable opportunity to comment on all correspondence received from and all proposed submissions to be made to any government patent office or authority related to the filing, prosecution and maintenance of such patent
filings, shall consult with Wyeth with respect thereto, and shall reasonably consider and address any of Wyeth’s comments on such correspondence and submissions. Each Party shall be responsible for fifty percent (50%) of Trubion’s out-of-pocket expenses incurred in connection with preparing, filing, prosecuting and maintaining such Category 1 Covered SMIP Improvement-related Patent Rights throughout the
Territory, other than out-of-pocket expenses for inventorship determinations and inventorship disputes. Wyeth shall reimburse Trubion on a quarterly basis within
forty-five (45) days of receiving an invoice accompanied by supporting documentation demonstrating the out-of-pocket expenses so incurred. On an annual basis,
during the last Calendar Quarter of each year, Trubion shall provide Wyeth with a good faith, written estimate of the out-of-pocket expenses reimbursable by Wyeth under
this Section 6.2.1(d)(i) that Trubion expects to incur in the following calendar year. In addition, if Trubion elects not to file a patent application on a Category 1 Covered SMIP Improvement, or to cease the prosecution and/or maintenance of
any Category 1 Covered SMIP Improvement-related Patent Right (except for abandonment of a patent application in favor of a patent application subsequently filed for purposes of continuing the prosecution of Patent Rights claiming the inventions
included in the 

  
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abandoned patent application), Trubion shall provide Wyeth with written notice immediately upon the decision to not file or continue the prosecution of such patent application or maintenance of
such patent. If Wyeth elects to continue such prosecution or maintenance, it shall notify Trubion in writing of such decision within ninety (90) days of receipt 01 Trubion’s written notice, in which case Trubion shall assign to Wyeth the
right to file, prosecute and maintain such Category 1 Covered SMIP Improvement-related Patent Right, and shall execute such documents and perform such acts, at Wyeth’s expense, as may be reasonably necessary to permit Wyeth to file, prosecute
and/or maintain such Category 1 Covered SMIP Improvement-related Patent Right. In the event that Wyeth continues the prosecution or maintenance of any Category 1 Covered SMIP Improvement-related Patent Right pursuant to this
Section 6.2.l(d)(i), Wyeth shall do so at its own expense, and Wyeth shall no longer be obligated to pay to Trubion any royalty payments that would be due solely with respect to any such Category 1 Covered SMIP Improvement-related Patent Right.

  

	 	(ii)	 Category 2 Covered SMIP Improvements. In the event that Wyeth makes any Category 2 Covered SMIP
Improvement (whether it is an invention solely by Wyeth or a Joint Invention), Wyeth shall have the first right and primary obligation to prepare, file, prosecute and maintain any Patent Rights covering such Category 2 Covered SMIP Improvement, at
its own expense, using patent counsel mutually agreeable to the Parties, such agreement not to be unreasonably withheld. Wyeth shall give Trubion a reasonable opportunity to review and comment on the text of any patent application with respect to
such Category 2 Covered SMIP Improvement before filing, shall consult with Trubion with respect thereto, shall reasonably consider and address any of Trubion’s comments, and shall supply Trubion with a copy 01 the patent application as filed,
together with notice of its filing date and serial number. Wyeth shall keep Trubion advised of the status of the actual and prospective patent filings (including, without limitation, the grant of any Patent Rights covering such Category 2 Covered
SMlP Improvement), shall provide Trubion with a reasonable opportunity to 

  
 61 

	 	
comment on all correspondence received from and all proposed submissions to be made to any government patent office or authority related to the filing, prosecution and maintenance of such patent
filings, shall consult with Trubion with respect thereto, and shall reasonably consider and address any of Trubion’s comments on such correspondence and submissions. If Wyeth elects not to file a patent application on a Category 2 Covered SMIP
Improvement, or to cease the prosecution and/or maintenance of any Category 2 Covered SMIP Improvement-related Patent Right (except for abandonment of a patent application in favor of a patent application subsequently filed for purposes of
continuing the prosecution of Patent Rights claiming the inventions included in the abandoned patent application), Wyeth shall provide Trubion with written notice immediately upon the decision to not file or continue the prosecution of such patent
application or maintenance of such patent. If Trubion elects to continue such prosecution or maintenance, it shall notify Wyeth in writing of such decision within ninety (90) days of receipt of Wyeth’s written notice, in which case Wyeth
shall assign to Trubion such Category 2 Covered SMIP Improvement-related Patent Right abandoned by Wyeth and shall execute such documents and perform such acts, at Trubion’s expense, as may be reasonably necessary to permit Trubion to file,
prosecute and/or maintain such Category 2 Covered SMIP Improvement-related Patent Right. 

  

	 	6.2.2.	 Enforcement of Patent Rights. 

 

	 	(a)	 Notice. lf either Wyeth or Trubion becomes aware of any infringement, anywhere in the Territory, of any
issued patent within the Trubion Patent Rights (including Product- Related Patent Rights), Wyeth Patent Rights or Joint Patent Rights, which infringing activity adversely affects or is reasonably expected to adversely affect any SMIP or Licensed
Product hereunder, it will promptly notify the other Party in writing to that effect and the Parties will consult with each other through the Joint Patent Committee regarding any actions to be taken with respect to such infringing activity;
provided, however, that neither Party is obligated to disclose confidential information of a Third Party (other than a sublicensee under this Agreement, to the extent such Party is permitted to do so under the terms of the sublicense).

  
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	 	(b)	 Product-Related Patent Rights. To the extent permitted under the Trubion Third Party Agreements, if
applicable, Wyeth shall have the first right, but not the obligation, to take action to obtain a discontinuance of infringement or bring suit against a Third Party infringer of Product-Related Patent Rights under which Wyeth has an exclusive license
to make, use and sell Licensed Products under this Agreement, to the extent such infringement involves a product directed against a Licensed Target. Wyeth shall have such first right within three (3) months from the date of notice and the right
to join Trubion as a party plaintiff. Wyeth shall be responsible for, and shall bear, all the out-of-pocket expenses of any suit brought by it claiming infringement of
any such Product-Related Patent Rights; provided that Trubion shall reimburse Wyeth for twenty percent (20%) of the out-of-pocket expenses incurred in connection
therewith. Trubion will cooperate with Wyeth in any such suit and shall have the right to consult with Wyeth and to participate in and be represented by independent counsel in such litigation at its own expense. Wyeth shall incur no liability to
Trubion as a consequence of such litigation or any unfavorable decision resulting therefrom, including any decision holding any of the Product-Related Patent Rights invalid or unenforceable. Any recoveries obtained by Wyeth as a result of any
proceeding against such Third Party infringer shall be allocated as follows: 

  

	 	(i)	 Such recovery shall first be used to reimburse each Party for all out-of-pocket litigation expenses in connection with such litigation paid by that Party; and 

  

	 	(ii)	 With respect to any remaining recovery, eighty percent (80%) shall go to Wyeth and twenty percent (20%)
shall go to Trubion. 

 If, after the expiration of the three (3) month period (or, if earlier, the date upon which
Wyeth provides written notice that it does not plan to bring suit), Wyeth has not obtained a discontinuance of such infringement of Product-Related Patent Rights or filed suit against any such Third Party infringer hereunder, then Trubion shall have
the right, but not the obligation, to bring suit against 

  
 63 

 
such Third Party infringer of the Product-Related Patent Rights under which Wyeth has an exclusive license under this Agreement, provided that each Party shall bear fifty percent (50%) of
the out-of-pocket expenses of such suit. Wyeth will cooperate with Trubion in any such suit for infringement of such Product-Related Patent Rights brought by Trubion
against a Third Party, and shall have the right to consult with Trubion and to participate in and be represented by independent counsel in such litigation at its own expense. Trubion shall incur no liability to Wyeth as a consequence of such
litigation or any unfavorable decision resulting therefrom, including any decision holding any of the Product-Related Patent Rights invalid or unenforceable. Any recoveries obtained by Trubion as a result of any such proceeding against a Third Party
infringer shall be allocated as follows: 
  

	 	(iii)	 Such recovery shall first be used to reimburse each Party for all out-of-pocket litigation expenses in connection with such litigation paid by that Party; and 

  

	 	(iv)	 With respect to any remaining recovery, one hundred percent (100%) shall go to Trubion.

  

	 	(c)	 Joint Patent Rights. With respect to any notice of a Third Party infringer of the Joint Patent Rights,
the Joint Patent Committee shall meet as soon as reasonably practicable to discuss such infringement and determine an appropriate course of action. Wyeth shall have the first right but not the obligation to bring an action against such Third Party
infringer or otherwise address such alleged infringement within three (3) months from the date of notice and to control such litigation or other means of addressing such infringement. Wyeth shall be responsible for, and shall bear, all the out-of-pocket expenses of any suit brought by it claiming infringement of any such Joint Patent Rights; provided that Trubion shall reimburse Wyeth for twenty percent
(20%) of the out-of-pocket expenses incurred in connection therewith. Trubion shall cooperate with Wyeth, at Wyeth’s expense, in any such suit brought by Wyeth and
shall have the right to consult with Wyeth and participate in and be represented by independent counsel in such litigation at its own expense. Wyeth shall incur no liability to Trubion as a consequence of such litigation or any unfavorable decision
resulting therefrom, including any decision holding any of the Joint Patent Rights invalid or 

  
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unenforceable. Any recovcries obtained by Wycth as a result of any proceeding against such Third Party infringer shall be allocated as follows: 

 

	 	(i)	 Such recovery shall first be used to reimburse each Party for all out-of-pocket litigation expenses in connection with such litigation paid by that Party; and 

  

	 	(ii)	 With respect to any remaining recovery, eighty percent (80%) shall go to Wyeth and twenty percent (20%)
shall go to Trubion. 

 If, after the expiration of the three (3) month period (or, if earlier, the date upon which
Wyeth provides written notice that it does not plan to bring suit) Wyeth elects not to take action against a Third Party infringer of the Joint Patent Rights and Trubion elects to bring an action, then Wyeth shall cooperate, at Trubion’s
expense, in such action. Trubion shall incur no liability to Wyeth as a consequence of such litigation or any unfavorable decision resulting therefrom, including any decision holding any of the Joint Patent Rights invalid or unenforceable. Any
recoveries obtained by Trubion shall go to Trubion. 
  

	 	6.2.3.	 Infringement and Third Party Licenses 

 

	 	(a)	 Infringement of Third Party Patents - Course of Action. If the research, Development, Manufacture
or Commercialization of any Licensed Product is alleged by a Third Party to infringe a Third Party’s patent, the Party becoming aware of such allegation shall promptly notify the other Party. 

Additionally, if either Party determines (with consultation by the Joint Patent Committee) that, based upon the review of a Third Party’s
patent or patent application or other intellectual property rights, it may be desirable to obtain a license from such Third Party with respect thereto, such Party shall promptly notify the other Party of such determination. In the event Wyeth
determines, after good faith consultation with Trubion through the Joint Patent Committee, that it is necessary or useful to obtain licenses under intellectual property rights from Third Parties (“Additional Third Party Licenses”) in order
to Develop, Manufacture or Commercialize Licensed Products under this Agreement, Wyeth shall be solely responsible for 

  
 65 

 
negotiating and obtaining any such Additional Third Party Licenses, but shall not be obligated to do so. Trubion may elect, in its sole discretion, to obtain one or more Third Party licenses that
are applicable to Trubion Technology in general but are not Licensed Product-specific (“Trubion Additional Third Party Licenses”); if Trubion so elects, then Trubion shall be solely responsible for negotiating and obtaining any such
licenses, but shall not be obligated to do so. 
  

	 	(b)	 Third Party Infringement Suit. If a Third Party sues a Party (the “Sued Party”) alleging that
the Sued Party or its Affiliates’ or sublicensees’ research, Development, Manufacture or Commercialization of any Licensed Product during the term of and pursuant to this Agreement infringes or will infringe said Third Party’s patent,
then, upon the Sued Party’s request and in connection with the Sued Party’s defense of any such Third Party infringement suit, the other Party shall provide reasonable assistance to the Sued Party for such defense. If both Wyeth and
Trubion are sued by a Third Party, then the Parties shall consult with one another through the Joint Patent Committee. Unless otherwise determined by the Joint Patent Committee, Wyeth will control the defense of any suit relating to Licensed
Products (whether one or both Parties are Sued Parties) and shall select counsel for such suit after consultation through the Joint Patent Committee. Trubion shall have the right to participate in and be represented by independent counsel in such
litigation at its own expense. If the alleged infringement is of claims related to the Trubion Technology utilized by Wyeth hereunder, Wyeth shall be responsible for, and shall bear, all the out-of-pocket expenses of such actions; provided that Trubion shall reimburse Wyeth for twenty percent (20%) of the
out-of-pocket expenses incurred in connection therewith. In the event Trubion is the Party paying such expenses, Trubion shall periodically, but no more than once per
Calendar Quarter, invoice Wyeth for its eighty percent (80%) share of expenses incurred. All invoices shall be accompanied by supporting documentation reasonably showing the expenses so incurred. Such invoices shall be paid within thirty
(30) days of receipt. In the event Wyeth is the Party paying such expenses, Wyeth shall receive a credit in the amount of Trubion’s share of such expenses, which credit shall be applied to royalties due to Trubion under Section 5.4,
as adjusted under Section 5.4.6; provided that, no such royalty payment to Trubion shall be 

  
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reduced by more than fifty percent (50%) in any Calendar Quarter as a result of such credit. Any portion of the credit not utilized due to the limitations of the preceding sentence shall be
carried over and credited to future royalty payments. 

  

	 	(c)	 Interference, Opposition, Revocation, and Declaratory Judgment Actions. If the Parties, though the Joint
Patent Committee, mutually determine that, based upon the review of a Third Party’s patent or patent application or other intellectual property rights, it may be desirable to provoke or institute an interference, opposition, revocation or
declaratory judgment action with respect thereto, then the ‘Parties shall consult with one another and shall reasonably cooperate in connection with such an action. Unless otherwise determined by the Joint Patent Committee, Wyeth will control
such action and shall select counsel for such action. Wyeth shall be responsible for, and shall bear, all the out-of-pocket expenses of such action; provided that
Trubion shall reimburse Wyeth for twenty percent (20%) of the out-of-pocket expenses incurred in connection therewith. Wyeth shall submit invoices to Trubion for such
expenses, such invoices to be accompanied by supporting documentation reasonably showing the expenses so incurred. Trubion shall have the right to participate in and be represented by independent counsel in such action at its own expense.

  

	 	6.2.4.	 Patent Certifications. Each Party shall immediately give written notice to the other of any
certification of which it becomes aware filed pursuant to 21 U.S.C. 5 355(b)(2)(A) or 5 355(j)(2)(A)(vii) (or any amendment or successor statute thereto), any similar statutory or regulatory requirement enacted in the future regarding
biologic products, or any similar statutory or regulatory requirement in any non-U.S. country in the Territory claiming that a Joint Patent Right, Wyeth Patent Right or a Trubion Patent Right covering a
Licensed Product is invalid or that infringement will not arise from the Manufacture, use or sale of a product by a Third Party. Upon the giving or receipt of such notice, Wyeth shall have the first right, but not the obligation, to bring an
infringement action against such Third Party. In such a case, Wyeth shall notify Trubion at least ten (10) days prior to the date set forth by statute or regulation of its intent to exercise, or not exercise, this right. Any infringement action
against a Third Party arising under this Section 6.2.4 shall be governed by the provisions of Section 6.2.2(b) hereof. 

  
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	 	6.2.5.	 Patent Term Restoration. The Parties hereto shall cooperate with each other in obtaining patent term
restoration, or its equivalent anywhere in the Territory, including under 3 5 U.S .C. 5 156 and its foreign counterparts, where applicable to the Trubion Patent Rights, Wyeth Patent Rights and Joint Patent Rights. If elections with respect to
obtaining such patent term restoration are to be made, Wyeth shall make such election (after consultation with Trubion through the Joint Patent Committee) and Trubion shall abide by such election. 

 

	 	6.3.	 Trademarks. Wyeth shall, in its sole discretion select and own all Licensed Product-related Trademarks,
trade dress, logos and copyrights and names to be used in connection with the Commercialization of any Licensed Product hereunder. Trubion shall neither use nor seek to register, anywhere in the Territory, any trademarks which are confusingly
similar to any Trademark or any other trademarks, trade names, trade dress or logos used by or on behalf of Wyeth or its sublicensees in connection with any Licensed Product; provided, however*, that nothing in this Section 6.3 shall be
construed to prevent Trubion from enforcing its own trademark, trade name, trade dress or logo rights or affect the Parties’ obligations under Section 4.13. 

 

	7.	 CONFIDENTIALITY. 

 

	 	7.1.	 Confidentiality. Except to the extent expressly authorized by this Agreement or otherwise agreed in
writing, the Parties agree that, for the term of this Agreement and for five (5) years thereafter, each Party (the “Receiving Party”), receiving any Confidential Information of the other Party (the “Disclosing Party”)
hereunder shall keep such Confidential Information confidential and shall not publish or otherwise disclose or use such Confidential Information for any purpose other than as provided for in this Agreement except for Confidential Information that
the Receiving Party can establish: 

  

	 	(a)	 was already known by the Receiving Party (other than under an obligation of confidentiality), at the time of
disclosure by the Disclosing Party and such Receiving Party has documentary evidence to that effect; 

  

	 	(b)	 was generally available to the public or otherwise part of the public domain at the time of its disclosure to
the Receiving Party; 

  

	 	(c)	 became generally available to the public or otherwise part of the public domain after its disclosure or
development, as the case may be, and other than through any act or omission of a Party in breach of this confidentiality obligation; 

  
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	 	(d)	 was disclosed to that Party, other than under an obligation of confidentiality, by a Third Party who had
110 obligation to the Disclosing Party not to disclose such information to others; or 

  

	 	(e)	 was independently discovered or developed by or on behalf of the Receiving Party without the use of the
Confidential Information belonging to the other Party and the Receiving Party has documentary evidence to that effect. 

  

	 	7.2.	 Authorized Disclosure and Use. 

 

	 	7.2.1.	 Disclosure. Notwithstanding the foregoing Section 7.1, each Party may disclose Confidential
Information belonging to the other Party to the extent such disclosure is reasonably necessary to: 

  

	 	(a)	 file or prosecute patent applications covering Trubion Know-How,
Wyeth Know-How or Joint Know-How as contemplated by this Agreement, in a manner consistent with decisions and recommendations of the Joint Patent Committee under Article
6, if the affected Party consents to such disclosure (such consent not to be unreasonably withheld or delayed); provided that a disclosure of a Party’s Confidential Information under this Section 7.2.l(a) shall be treated as a
publication under Section 7.4.3, and shall be subject to the requirements of advance notice, review period and opportunity to file patent application(s), as set forth in Section 7.4.3, 

 

	 	(b)	 prosecute or defend litigation, 

 

	 	(c)	 exercise rights hereunder provided such disclosure is covered by terms of confidentiality similar to
those set forth herein, 

  

	 	(d)	 facilitate discussions with prospective investors (other than pharmaceutical or biotechnology companies)
in connection with financing arrangements (not involving any license, collaboration or other arrangement relating to such Party’s technology or products) or a proposed acquisition of such Party, subject to appropriate confidentiality agreements
and limiting such disclosure to disclosure of the terms and conditions of this Agreement and Know-How to the extent contained in such Party’s patent applications; and 

 

	 	(e)	 comply with applicable governmental laws and regulations. 

  
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 In the event that a Party shall reasonably deem it necessary to disclose, pursuant to this
Section 7.2.1, Confidential Information belonging to the other Party, the Disclosing Party shall to the extent possible give reasonable advance notice of such disclosure to the other Party and take reasonable measures to ensure confidential
treatment of such information. 
  

	 	7.2.2.	 Use. Notwithstanding the foregoing Section 7.1, each Party shall have the right to use Confidential
Information of the other Party in carrying out its responsibilities under this Agreement in the research, Development, Manufacture and Commercialization of Licensed Products. 

 

	 	7.3.	 SEC Filings. Either Party may disclose the terms of this Agreement to the extent required, in the
reasonable opinion of such Party’s legal counsel, to comply with applicable laws, including, without limitation, the rules and regulations promulgated by the United States Securities and Exchange Commission. Notwithstanding the foregoing,
before disclosing this Agreement or any of the terms hereof pursuant to this Section 7.3, the Parties will reasonably consult with one another on the terms of this Agreement to be redacted in malting any such disclosure. If a Party discloses
this Agreement or any of the terms hereof in accordance with this Section 7.3, such Party agrees, at its own expense, to seek confidential treatment 01 portions of this Agreement or such terms, as may be reasonably requested by the other Party.

  

	 	7.4.	 Public Announcements; Publications 

 

	 	7.4.1.	 Coordination. The Parties agree on the importance of coordinating their public announcements respecting
this Agreement and the subject matter thereof (other than academic, scientific or medical publications that are subject to the publication provision set forth below). Trubion and Wyeth shall, from time to time, and at the request of the other Party,
discuss and agree on the general information content relating to this Agreement (including relating to the Research Program and Development Program, and/or to research, Development, Manufacture and/or Commercialization of Licensed Products) which
may be publicly disclosed (including, without limitation, by means of any printed publication or oral presentation). 

  

	 	7.4.2.	 Announcements. Except as may be expressly permitted under Section 7.3 or Section 7.4.3 or as
may be appropriate for Wyeth to make in connection with its Commercialization activities as contemplated hereunder, subject to Sections 7.1 and 7.2 hereof, neither Party will make any public announcement regarding this Agreement, the Research
Program or the Development Program, 

  
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and/or the research, Development, Manufacturing or Commercialization of Licensed Products without the prior written approval of the other Party. 

 

	 	7.4.3.	 Publications. During the term of this Agreement, each Party will submit to the other Party for review
and approval all proposed academic, scientific and medical publications and public presentations relating to the Research Program, the Development Program and/or to the research, Development, Manufacture and/or Commercialization of any Licensed
Product, or any proposed disclosure under Section 7.2.l(a), for review in connection with preservation of Patent Rights and/or to determine whether any of such other Party’s Confidential Information should be modified or deleted. Written
copies of such proposed publications and presentations shall be submitted to the non-publishing Party no later than thirty (30) days before submission for publication or presentation and the non
publishing Party shall provide its comments with respect to such publications and presentations within fifteen (1 5) business days of its receipt of such written copy. The review period may be extended for an additional thirty (30) days in the
event the non-publishing Party can demonstrate reasonable need for such extension, including, but not limited to, the preparation and filing of patent applications. By mutual agreement, this period may be
further extended. Wyeth and Trubion will each comply with standard academic practice regarding authorship of scientific publications and recognition of contribution of other parties in any publications relating to the Research Program, the
Development Program and/or to the research, Development, Manufacture and/or Commercialization of any Licensed Product. 

  

	8.	 REPRESENTATIONS AND WARRANTIES. 

 

	 	8.1.	 Representations and Warranties of Each Party. Each or Trubion and Wyeth hereby represents and warrants
to the other Party hereto as follows: 

  

	 	(a)	 it is a corporation or entity duly organized and validly existing under the laws of the state or other
jurisdiction of its incorporation or formation; 

  

	 	(b)	 the execution, delivery and performance of this Agreement by such Party has been duly authorized by all
requisite corporate action and does not require any shareholder action or approval; 

  
 71 

	 	(c)	 it has the power and authority to execute and deliver this Agreement and to perform its obligations and
to grant the licenses granted by it to the other Party pursuant to this Agreement; 

  

	 	(d)	 the execution, delivery and performance by such Party of this Agreement and its compliance with the
terms and provisions hereof does not and will not conflict with or result in a breach of any of the terms and provisions of or constitute a default under (i) any agreement or instrument binding or affecting it or the subject matter of this
Agreement; (ii) the provisions of its charter or operative documents or bylaws; or (iii) any order, writ, injunction or decree of any court or governmental authority entered against it or by which any of its property is bound, except where
such conflict, breach or default would not materially impact (A) the Party’s ability to meet its obligations hereunder or (B) the rights granted to the other Party hereunder; and 

 

	 	(e)	 it has not granted to any Third Party any right or license which would conflict in any material respect
with the rights granted by it to the other Party hereunder. 

  

	 	8.2.	 Additional Representations and Warranties of Trubion In addition to the representations and warranties
made by Trubion in Section 8.1, Trubion, subject to Section 8.7, hereby represents and warrants to Wyeth that as of the Signing Date: 

  

	 	(a)	 except as disclosed in Exhibit 8.2(d) attached hereto, Trubion is the sole and exclusive owner of
the Trubion Patent Rights and Trubion has not placed, or suffered to be placed, any liens, charges or encumbrances on or against the Trubion Patent Rights; 

  

	 	(b)	 Exhibit 1.129 is a true and complete list of Trubion Patent Rights that pertain to Licensed
Products, provided that an inadvertent omission from such list may be cured by amending Exhibit 1.129; 

  

	 	(c)	 the Trubion Patent Rights are existing and, to Trubion’s knowledge, no issued or granted patents
within the Trubion Patent Rights are invalid or unenforceable; 

  

	 	(d)	 except as disclosed in Exhibit 8.2(d) attached hereto, Trubion has no knowledge that any Third
Party has any right, title or interest in or to any of the Trubion Patent Rights; 

  
 72 

	 	(e)	 except as set forth in Exhibit 8.2(e) attached hereto, no Trubion Patent Right listed in
Exhibit 1.129 attached hereto is subject to any funding agreement with any government or government agency; 

  

	 	(f)	 Trubion has received no written notice alleging infringement of a Third Party Patent Right in connection
with its research and Development of SMIPs directed against a Trubion Target, and Trubion has disclosed to Wyeth all material information of which Trubion is aware as to whether the research, Development, Manufacture, use or sale of SMIPs directed
against a Trubion Target, in the form that is the subject of the clinical studies ongoing as of the Signing Date, if such SMIPs were researched, Developed, Manufactured, used or sold as of the Signing Date, infringes or would infringe issued or
granted patents owned by a Third Party as of the Signing Date; 

  

	 	(g)	 the Trubion Patent Rights are not subject to any litigation, judgments or settlements against or owed by
Trubion, nor has Trubion received written notice of any threats of such litigation; 

  

	 	(h)	 Trubion is in compliance in all material respects with all agreements with Third Parties relating to
Licensed Products that are sublicensed to Wyeth hereunder; 

  

	 	(i)	 Trubion has not knowingly used any Know-How misappropriated from a
Third Party in connection with a Licensed Product to be provided for Commercialization under this Agreement, and Trubion is not aware of any claim by a Third Party that Know-How misappropriated from such Third
Party has been used by Trubion in its Development of SMIPs directed against a Trubion Target; and 

  

	 	(j)	 the Trubion Patent Rights are not the subject of any interference, opposition, reissue or reexamination
proceeding in the United States or, to the knowledge of Trubion, any opposition proceeding outside of the United States. 

  
 73 

	 	8.3.	 Mutual Covenant. Each Party covenants to the other Party that it shall at all times comply with all
applicable material laws and regulations relating to its activities under this Agreement. 

  

	 	8.4.	 Additional Covenants of Trubion. During the term of this Agreement, Trubion will use diligent efforts
not to materially breach any agreement between Trubion and a Third Party that provides Trubion Patent Rights pertaining to the research, Development, Manufacture or Commercialization of any Licensed Product, and it will provide Wyeth promptly with
notice of any such alleged breach. The foregoing sentence shall not be construed to prevent the termination of any such Third-Party agreement by Trubion; provided, however, that Trubion shall not terminate any such Third-Party agreement
without obtaining Wyeth’s prior written consent, which consent shall not be unreasonably withheld or delayed. During the term of this Agreement, Trubion will not knowingly use any Know-How misappropriated
from a Third Party in connection with any Licensed Product being provided for Commercialization under this Agreement. 

  

	 	8.5.	 Representation by Legal Counsel. Each Party hereto represents that it has been represented by
legal counsel in connection with this Agreement and acknowledges that it has participated in the drafting hereof, In interpreting and applying the terms and provisions of this Agreement, the Parties agree that no presumption shall exist or be
implied against the Party which drafted such terms and provisions. 

  

	 	8.6.	 No Inconsistent Agreements. Neither Party has in effect and after the Signing Date neither Party shall
enter into any oral or written agreement or arrangement that would be inconsistent with its obligations under this Agreement. 

  

	 	8.7.	 Disclaimer. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN SECTIONS 8.1, 8.2 AND 8.5, THE PARTIES MAKE NO
REPRESENTATIONS AND EXTEND NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, AND PARTICULARLY THAT LICENSED PRODUCTS WILL BE SUCCESSFULLY DEVELOPED HEREUNDER, AND IF LICENSED PRODUCTS ARE DEVELOPED, WITH RESPECT TO SUCH LICENSED PRODUCTS, THE
PARTIES DISCLAIM ALL IMPLIED WARRANTIES OF TITLE, NON-INFRINGEMENT, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. 

 

	9.	 GOVERNMENT APPROVALS; TERM AND TERMINATION. 

 

	 	9.1.	 HSR Filing. Each Party shall be responsible for its own costs, expenses, and filing fees associated with
any HSR Filing; provided, however, that Wyeth shall be solely responsible for any fees (other than penalties that 

  
 74 

	 	
may be incun-ed as a result of actions or omissions on the part of Trubion) required to be paid to any government agency in connection with making any such
HSR Filing. 

  

	 	9.2.	 Other Government Approvals. Trubion and Wyeth will cooperate and use respectively all reasonable efforts
to make all registrations, filings and applications, to give all notices and to obtain as soon as practicable all governmental or other consents, transfers, approvals, orders, qualifications authorizations, permits and waivers, if any, and to do all
other things necessary or desirable for the consummation of the transactions as contemplated hereby. 

  

	 	9.3.	 Term. The term of this Agreement will commence on the Signing Date and shall extend, unless this
Agreement is terminated earlier in accordance with this Article 9, on a Licensed Product by Licensed Product and country by country basis until such time as the Royalty Period with respect to the sale of such Licensed Product in such country
expires. 

  

	 	9.4.	 Termination Upon HSR Denial. This Agreement shall terminate (a) at Wyeth’s option,
immediately upon written notice to Trubion, in the event that the United States Federal Trade Commission and/or the United States Department of Justice shall seek a preliminary injunction under the HSR Act against Trubion and Wyeth to enjoin the
transactions contemplated by this Agreement, (b) at the election of either Party, immediately upon written notice to the other Party, in the event that the United States Federal Trade Commission and/or the United States Department of Justice
shall obtain a preliminary injunction under the HSR Act against Trubion and Wyeth to enjoin the transactions contemplated by this Agreement, or (c) at the election of either Party, immediately upon written notice to the other Party, in the
event that the HSR Clearance Date shall not have occurred on or prior to one hundred eighty (180) days after the effective date of the HSR Filing. 

  

	 	9.5.	 Material Breach. In the event that either Party commits a material breach of its representations,
warranties or obligations under this Agreement, the other Party may terminate this Agreement (a) on a Licensed Target by Licensed Target and country by country basis, to the extent that such material breach relates to Licensed Product(s)
directed against such Licensed Target(s) in such country(ies) or (b) in its entirety only if such material breach fundamentally frustrates the objectives or transactions contemplated by this Agreement taken as a whole. If a Party elects to
exercise such right to terminate, it shall do so by providing written notice of the alleged breach (the “Notice of Breach”) to the breaching Party. If such material breach pertains to the payment of undisputed amounts payable under this
Agreement and remains uncured for thirty (30) days after the breaching Party’s receipt of such Notice of Breach or, if such material breach pertains to another material breach (other than for
non-payment) and 

  
 75 

	 	
remains uncured for one hundred twcnty (120) days after the breaching Party’s receipt of such Notice of Breach, then the non-breaching Party may
terminate this Agreement, as and to the extent permitted in (a) or (b) above, on fifteen (15) days notice by giving a written notice of termination (“Notice of Termination”) to the breaching Party; provided, however, that
if such breach (other than for non-payment) is not susceptible to cure within the initial 120-day period and the breaching Party uses continuous, diligent, good faith
efforts to cure such breach, it shall document such efforts by written notice to the non-breaching Party on or before the end of such 120- day period, and the stated
cure period will be extended by an additional one hundred twenty (120) days. This Agreement shall be deemed terminated (as and to the extent permitted in (a) or (b) above) fifteen (1 5) days after the breaching Party’s receipt of such
Notice of Termination, unless the breaching Party has fully cured the breach prior to the expiration of such 15-day period. 

In the event that Trubion is the breaching Party and fails to cure any such material breach within the applicable time period(s) set forth
above, Wyeth, within sixty (60) days after the expiration 01 the cure period for such breach, may elect, in lieu of terminating this Agreement, by written notice to Trubion (a “Notice of Modification”), to modify the terms of this
Agreement, as (and only to the extent) provided in Section 9.8, on a Licensed Target-by-Licensed Target and country-by-country basis (but only to the extent such
material breach relates to Licensed Product(s) directed against such Licensed Target(s) in such country(ies)), in which event, Wyeth shall be deemed to have waived its right to terminate this Agreement under this Section 9.5 with respect to
such Licensed Target(s) in such country(ies) only with respect to the material breach giving rise to such action under this Section 9.5. Notwithstanding the foregoing, a Party shall not be in breach of its obligations under this Agreement to
the extent that such breach was caused by the other Party’s failure to perform its obligations hereunder. 
  

	 	9.6.	 Termination by Wyeth. 

 

	 	9.6.1.	 Termination Without Cause. Commencing on the second anniversary of the Effective Date, Wyeth shall have
the right, exercisable upon ninety (90) days prior written notice to Trubion, to terminate this Agreement either (a) in its entirety, or (b) on a Licensed Target by Licensed Target and country by country basis. Wyeth’s rights
under this Section 9.6.1 are separate from and in addition to its rights to terminate the Research Program under Section 3.3.2 hereof. 

  

	 	9.6.2.	 Termination for a Material Safety or Regulatory Issue. Wyeth shall have the right to terminate
this Agreement, at any time, on a Licensed Target by Licensed Target basis, by giving 

  
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sixty (60) days prior written notice to Trubion in the event of any safety or regulatory issue that would have a material adverse effect on Wyeth’s ability to research, Develop,
Manufacture or Commercialize any Licensed Product directed against such Licensed Target, as determined in Wyeth’s reasonable judgment and according to Wyeth’s standard internal procedures for evaluating such safety or regulatory issues.
Effects of such termination shall be as set forth in Section 9.7.4. 

  

	 	9.7.	 Effects of Termination. 

 

	 	9.7.1.	 Effect of Termination by Wyeth for Cause. 

 

	 	(a)	 Without limiting any other legal or equitable remedies that Wyeth or Trubion may have, subject to
Section 11.3, if this Agreement is terminated in its entirety by Wyeth for cause under Section 9.5, the following provisions shall apply: 

  

	 	(i)	 all licenses granted by each Party to the other Party under this Agreement shall terminate (except as
provided in Section 9.7.10 below); 

  

	 	(ii)	 during the one (1) year period after the effective date of such termination, Trubion shall have the
right to negotiate with Wyeth an agreement which grants to Trubion a non-exclusive license (with the right to grant sublicenses) to practice, use and exploit the Wyeth Applied Technology with respect to the
research, Development, Manufacture and Commercialization of Licensed Products on commercially reasonable terms. If Trubion exercises such right, Wyeth shall negotiate the terms of such license with Trubion diligently and in good faith;
provided that, if Trubion and Wyeth negotiate, but do not enter into, such non-exclusive license, Wyeth shall not enter into any agreement granting a license to a Third Party under the Wyeth Applied
Technology within one (1) year after the end of such negotiations on terms more favorable to such Third Party than those last offered by Wyeth to Trubion, without first offering Trubion, for a period of not less than sixty (60) days, the
opportunity to review such terms after full disclosure thereof and enter into a non-exclusive license on such more favorable terms, and, if Trubion accepts such more favorable terms, the Parties shall promptly
negotiate definitive agreements relating thereto; 

  
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	 	(iii)	 during the one (1) year period after the effective date of such termination, Trubion shall have the
right to negotiate with Wyeth for the transfer of Product Data and Filings to Trubion, and for the grant by Wyeth to Trubion of the right and license to use the Licensed Product-specific Trademarks and Product-specific names pertaining to the
Licensed Product(s) as existing at the time of termination (collectively, “Existing Trademarks”), on commercially reasonable terms. If Trubion exercises such right, Wyeth shall negotiate the terms of such transfer and license with Trubion
diligently and in good faith; provided that, if Trubion and Wyeth negotiate but do not enter into such an agreement, Wyeth shall not enter into any agreement granting such rights to a Third Party within one (1) year after the end of such
negotiation on terms more favorable to such Third Party than those last offered by Wyeth to Trubion, without first offering Trubion, for a period of not less than sixty (60) days, the opportunity to review such terms after full disclosure
thereof and enter into such an agreement on such more favorable terms, and, if Trubion accepts such more favorable terms, the Parties shall promptly negotiate definitive agreements relating thereto; and 

 

	 	(iv)	 subject to the provisions of Section 9.9, this Agreement shall be of no further force or effect.

  

	 	(b)	 Without limiting any other legal or equitable remedies that Wyeth or Trubion may have, subject to
Section 11.3, if this Agreement is terminated by Wyeth for cause under Section 9.5 with respect to a Licensed Target in all countries, but not in its entirety, the following provisions shall apply: 

 

	 	(i)	 if such Licensed Target is a Trubion Target, all of the Parties’ rights and obligations under
Article 3 in connection with the Research Program shall cease in their entirety; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall remain payable in accordance with the
provisions of Article 3; 

  

	 	(ii)	 if such Licensed Target is a Wyeth Target, all of the Parties’ rights and obligations under Article
3 in connection with the Research Program shall continue, subject to Wyeth’s option, exercisable in its sole discretion, to terminate the Research Program as 

  
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follows: Wyeth shall exercise such option to terminate the Research Program (if it so elects) by a written statement to that effect included in Wyeth’s Notice of Termination (described in
Section 9.5 above). If Wyeth exercises such option to terminate the Research Program, all of the Parties’ rights and obligations under Article 3 in connection with the Research Program shall cease in their entirety fifteen (15) days
after Trubion’s receipt of such Notice of Termination; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall remain payable in accordance with the provisions of Article 3;

  

	 	(iii)	 if such terminated Licensed Target is the CD20 Antigen, Wyeth shall have no further obligation to reimburse
Trubion under Section 4.6 with respect to expenses incurred after the effective date of termination; 

  

	 	(iv)	 all licenses granted by each Party to the other Party under this Agreement with respect to Licensed Products
directed against such Licensed Target shall terminate (except as provided in Section 9.7.10 below); 

  

	 	(v)	 the provisions of Section 9.7.1(a)(ii), with such changes as are appropriate in the context of such
limited termination, shall apply with respect to the Licensed Products directed against such Licensed Target; and 

  

	 	(vi)	 the provisions of Section 9.7.l(a)(iii), with such changes as are appropriate in the context of such
limited termination, shall apply with respect to Product Data and Filings, and Existing Trademarks, relating to the Licensed Products directed against such Licensed Target. 

 

	 	(c)	 Without limiting any other legal or equitable remedies that Wyeth or Trubion may have, subject to
Section 11.3, if this Agreement is terminated by Wyeth for cause under Section 9.5 with respect to all Licensed Targets in a country, but not in its entirety, the following provisions shall apply: 

 

	 	(i)	 if such country is a Major Market Country, all of the Parties’ rights and obligations under Article
3 in 

  
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connection with the Research Program shall cease in their entirety; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall
remain payable in accordance with the provisions of Article 3; 

  

	 	(ii)	 if such country is not a Major Market Country, all of the Parties’ rights and obligations under
Article 3 in connection with the Research Program shall continue, subject to Wyeth’s option, exercisable in its sole discretion, to terminate the Research Program as follows: Wyeth shall exercise such option to terminate the Research Program
(if it so elects) by a written statement to that effect included in Wyeth’s Notice of Termination (described in Section 9.5 above). If Wyeth exercises such option to terminate the Research Program, all of the Parties’ rights and
obligations under Article 3 in connection with the Research Program shall cease in their entirety fifteen (15) days after Trubion’s receipt of such Notice of Termination; provided that all amounts due for research performed and
costs incurred prior to the date of such termination shall remain payable in accordance with the provisions of Article 3; 

  

	 	(iii)	 all licenses granted by each Party to the other Party under this Agreement with respect to such country
shall terminate (except as provided in Section 9.7.10 below); and 

  

	 	(iv)	 the term “Territory” as used in this Agreement shall thereafter exclude such country;

  

	 	(v)	 except as provided in Section 9.9, neither Wyeth nor Trubion shall have any further obligations
under this Agreement with respect to such country; 

  

	 	(vi)	 the provisions of Section 9.7.l(a)(ii), with such changes as are appropriate in the context of such
limited termination, shall apply with respect to Licensed Products in such country; and 

  

	 	(vii)	 the provisions of Section 9.7.1(a)(iii), with such changes as are appropriate in the context of
such limited termination, shall apply with respect to Product Data and Filings, and Existing Trademarks, relating to Licensed Products in such country. 

  
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	 	9.7.2.	 Effect of Termination by Trubion for Cause 

 

	 	(a)	 Without limiting any other legal or equitable remedies that Trubion or Wyeth may have, subject to
Section 11.3, if this Agreement is terminated in its entirety by Trubion for cause under Section 9.5, the following provisions shall apply: 

  

	 	(i)	 all licenses granted by each Party to the other Party under this Agreement shall terminate (except as
provided in Section 9.7.10 below); 

  

	 	(ii)	 Wyeth and Trubion shall, upon Trubion’s request, such request made within ninety (90) days
after such termination, enter into negotiations of a non-execlusive license from Wyeth to Trubion under which Wyeth will grant to Trubion a non-exclusive license (with the right to grant sublicenses) to
practice, use and exploit the Wyeth Applied Technology with respect to the research, Development, Manufacture and Commercialization of Licensed Products as constituted at the time of termination of this Agreement. The Parties hereby agree that such
license shall include, inter alia, provisions whereby Trubion shall agree (A) to comply with the applicable requirements of any Third Party license to which the use or exploitation of such Wyeth Applied Technology is subject including, but not
limited to the payment of royalties; (B) with respect to any CD20 Products or HER2 Products, to pay to Wyeth (I) if such termination occurs prior to BLA filing in a Major Market Country, royalties and Additional Research and Development
Expense Payments in amounts equal to twenty-five percent (25%) of those amounts Wyeth would have been obligated to pay Trubion had this Agreement remained in full force and effect or (11) if such termination occurs after BLA filing in a Major
Market Country, royalties and Additional Research and Development Expense Payments in amounts equal to fifty percent (50%) of those amounts Wyeth would have been obligated to pay Trubion had this Agreement remained in full force and effect;
(C) with respect lo any Licensed Products other than CD20 Products and HER2 Products, to pay to Wyeth royalties and other non-royalty payments on commercially reasonable terms; and (D) that Trubion
shall have no other financial obligations to Wyeth; 

  
 81 

	 	(iii)	 the provisions of Section 9.7.7 (Post-Termination Transfer of Product Data and Filings and Existing
Trademarks) shall apply; 

  

	 	(iv)	 the provisions of Section 9.7.8 (Manufacturing of Licensed Products After Termination) shall apply;
and 

  

	 	(v)	 subject to the provisions of Section 9.9, this Agreement shall be of no further force or effect.

  

	 	(b)	 Without limiting any other legal or equitable remedies that Trubion or Wyeth may have, subject to
Section 11.3, if this Agreement is terminated by Trubion for cause under Section 9.5 with respect to a Licensed Target in all countries, but not in its entirety, the following provisions shall apply: 

 

	 	(i)	 all of the Parties’ rights and obligations under Article 3 in connection with the Research Program
shall cease in their entirety; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall remain payable in accordance with the provisions of Article 3; 

 

	 	(ii)	 if such terminated Licensed Target is the CD20 Antigen, Wyeth shall have no further obligation to
reimburse Trubion under Section 4.6 with respect to expenses incurred after the effective date of termination; 

  

	 	(iii)	 all licenses granted by each Party to the other Party under this Agreement with respect to Licensed
Products directed against such Licensed Target shall terminate (except as provided in Section 9.7.10 below); 

  

	 	(iv)	 the provisions of Section 9.7.2(a)(ii) (Wyeth’s grant of a
non-exclusive license to Trubion under Wyeth Applied Technology), with such changes as arc appropriate in the context of such limited termination, shall apply to Licensed Products directed against such
Licensed Target; 

  

	 	(v)	 the provisions of Section 9.7.7 (Post-Termination Transfer of Product Data and Filings and Existing
Trademarks), with such changes as are appropriate in the context of such limited termination, shall apply with respect to Product Data and Filings, and Existing Trademarks, related to Licensed Products directed against such Licensed Target; and

  
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	 	(vi)	 the provisions of Section 9.7.8 (Manufacturing of Licensed Products After Termination), with such changes
as are appropriate in the context of such limited termination, shall apply with respect to Licensed Products directed against such Licensed Target. 

  

	 	(c)	 Without limiting any other legal or equitable remedies that Trubion or Wyeth may have, subject to
Section 11.3, if this Agreement is terminated by Trubion for cause under Section 9.5 with respect to all Licensed Targets in a country, but not in its entirety, the following provisions shall apply: 

 

	 	(i)	 all of the Parties’ rights and obligations under Article 3 in connection with the Research Program shall
cease in their entirety; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall remain payable in accordance with the provisions of Article 3; 

 

	 	(ii)	 all licenses granted by each Party to the other Party under this Agreement with respect to such country shall
terminate (except as provided in Section 9.7.10 below); 

  

	 	(iii)	 the provisions of Section 9.7.2(a)(ii) (Wyeth’s grant of a
non-exclusive license to Trubion under Wyeth Applied Technology), with such changes as are appropriate in the context of such limited termination, shall apply to a
non-exclusive license to research, Develop, Manufacture and Commercialize Licensed Products in such country; 

  

	 	(iv)	 the provisions of Section 9.7.7 (Post-Termination Transfer of Product Data and Filings and Existing
Trademarks), with such changes as are appropriate in the context of such limited termination, shall apply with respect to Product Data and Filings, and Existing Trademarks, related to Licensed Products in such country; and 

 

	 	(v)	 the term “Territory” as used in this Agreement shall thereafter exclude such country.

  
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	 	9.7.3.	 Effect of Termination by Wyeth Without Cause. 

 

	 	(a)	 If this Agreement is terminated in its entirety by Wyeth under Section 9.6.1, the following provisions
shall apply: 

  

	 	(i)	 all licenses granted by each Party to the other Party under this Agreement shall terminate (except as provided
in Section 9.7.10 below); 

  

	 	(ii)	 the provisions of Section 9.7.2(a)(ii) (Wyeth’s grant of a
non-exclusive license to Trubion under Wyeth Applied Technology) shall apply; 

  

	 	(iii)	 the provisions of Section 9.7.7 (Post-Termination Transfer of Product Data and Filings and Existing
Trademarks) shall apply; 

  

	 	(iv)	 the provisions of Section 9.7.8 (Manufacturing of Licensed Products After Termination) shall apply; and

  

	 	(v)	 subject to the provisions of Section 9.9, this Agreement shall be of no further force or effect.

  

	 	(b)	 If this Agreement is terminated by Wyeth under Section 9.6.1 with respect to a Licensed Target in all
countries, but not in its entirety, the following provisions shall apply: 

  

	 	(i)	 all of the Parties’ rights and obligations under Article 3 in connection with the Research Program shall
cease in their entirety; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall remain payable in accordance with the provisions of Article 3; 

 

	 	(ii)	 if such terminated Licensed Target is the CD20 Antigen, Wyeth shall have no further obligation to reimburse
Trubion under Section 4.6 with respect to expenses incurred after the effective date of termination; 

  

	 	(iii)	 all licenses granted by each Party to the other Party under this Agreement with respect to Licensed Products
directed against such Licensed Target shall terminate (except as provided in Section 9.7.10 below); 

  
 84 

	 	(iv)	 the provisions of Section 9.7.2(a)(ii) (Wyeth’s grant of a
non-exclusive license to Trubion under Wyeth Applied Technology), with such changes as are appropriate in the context of such limited termination, shall apply to a
non-exclusive license to research, Develop, Manufacture and Commercialize Licensed Products directed against such Licensed Target; 

 

	 	(v)	 the provisions of Section 9.7.7 (Post-Termination Transfer of Product Data and Filings and Existing
Trademarks), with such changes as are appropriate in the context of such limited termination, shall apply with respect to Product Data and Filings, and Existing Trademarks, related to Licensed Products directed against such Licensed Target; and

  

	 	(vi)	 the provisions of Section 9.7.8 (Manufacturing of Licensed Products After Termination), with such changes
as are appropriate in the context of such limited termination, shall apply with respect to Licensed Products directed against such Licensed Target. 

  

	 	(c)	 If this Agreement is terminated by Wyeth under Section 9.6.1 with respect to all Licensed Targets in a
country, but not in its entirety, the following provisions shall apply: 

  

	 	(i)	 if such country is a Major Market Country, all of the Parties’ rights and obligations under Article 3 in
connection with the Research Program shall cease in their entirety; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall remain payable in accordance with the provisions of
Article 3; and if such country is not a Major Market Country, all of the Parties’ rights and obligations under Article 3 in connection with the Research Program shall continue; 

 

	 	(ii)	 all licenses granted by each Party to the other Party under this Agreement with respect to such country shall
terminate (except as provided in Section 9.7.10 below); 

  

	 	(iii)	 the provisions of Section 9.7.2(a)(ii) (Wyeth’s grant of a
non-exclusive license to Trubion under Wyeth Applied Technology), with such changes as are appropriate in the context of such limited termination, shall apply to a
non-exclusive license to research, Develop, Manufacture and Commercialize Licensed Products in such country; 

  
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	 	(iv)	 the provisions of Section 9.7.7 (Post-Termination Transfer of Product Data and Filings and Existing
Trademarks), with such changes as are appropriate in the context of such limited termination, shall apply with respect to Product Data and Filings, and Existing Trademarks, related to Licensed Products in such country; and 

 

	 	(v)	 the term “Territory” as used in this Agreement shall thereafter exclude such country.

  

	 	9.7.4.	 Effect of Termination by Wyeth for a Material Safety or Regulatory Issue. If this Agreement is
terminated with respect to a Licensed Target by Wyeth under Section 9.6.2, the following provisions shall apply: 

  

	 	(a)	 all of the Parties’ rights and obligations under Article 3 in connection with the Research Program shall
continue; 

  

	 	(b)	 if such terminated Licensed Target is the CD20 Antigen, Wyeth shall have no further obligation to reimburse
Trubion under Section 4.6 with respect to with respect to expenses incurred after the effective date of termination; 

  

	 	(c)	 all licenses granted by each Party to the other Party under this Agreement with respect to Licensed Products
directed against such Licensed Target shall terminate (except as provided in Section 9.7.10 below); 

  

	 	(d)	 unless the basis of termination under Section 9.6.2 is the imposition of a. clinical hold by a Regulatory
Authority, a determination by Wyeth to place a hold on further clinical studies of a Licensed Product directed against such Licensed Target (such determination to be made by Wyeth in accordance with its standard procedures of addressing such safety
issues) or a withdrawal of a Licensed Product from the market for patient safety reasons, whether voluntary or otherwise, the provisions of Section 9.7.2(a)(ii) (Wyeth’s grant of a non-exclusive
license to Trubion under Wyeth Applied Technology), with such changes as are appropriate in the context of such limited termination, shall apply to a non-exclusive license to research, Develop, Manufacture and
Commercialize Licensed Products directed against such Licensed Target; 

  
 86 

	 	(e)	 the provisions of Section 9.7.7 (Post-Termination Transfer of Product Data and Filings and Existing
Trademarks), with such changes as are appropriate in the context of such limited termination, shall apply with respect to Product Data and Filings, and Existing Trademarks, related to Licensed Products directed against such Licensed Target; and

  

	 	(f)	 unless the basis of termination under Section 9.6.2 is the imposition of a clinical hold by a Regulatory
Authority, a determination by Wyeth to place a hold on further clinical studies of a Licensed Product directed against such Licensed Target (such determination to be made by Wyeth in accordance with its standard procedures of addressing such safety
issues) or a withdrawal of a Licensed Product from the market for patient safety reasons, whether voluntary or otherwise, the provisions of Section 9.7.8 (Manufacturing of Licensed Products After Termination), with such changes as are
appropriate in the context of such limited termination, shall apply with respect to Licensed Products directed against such Licensed Target. 

  

	 	9.7.5.	 Post-Termination Rights to Wyeth Technology and Trubion Technology. Except as otherwise expressly set
forth in this Agreement, expiration or termination of this Agreement for any reason shall have no effect on Wyeth’s rights with respect to the Wyeth Technology, and Trubion shall have no right, title or interest in or to any of the Wyeth
Technology, and such expiration or termination shall have no effect on Trubion’s rights with respect to the Trubion Technology, and Wyeth shall have no right, title or interest in or to any of the Trubion Technology. 

 

	 	9.7.6.	 Post-Termination Licenses to Wyeth Technology. In the event that Wyeth grants to Trubion a license under
any Wyeth Technology pursuant to Section 9.7.1, 9.7.2, 9.7.3 or 9.7.4, such license shall include, inter alia, provisions whereby Trubion shall agree to comply with the applicable requirements of any Third Party license to which the use
or exploitation of any such items may be subject including, but not limited to, the payment of royalties. 

  

	 	9.7.7.	 Post-Termination Transfer of Product Data and Filings and Existing Trademarks. The following provisions
shall apply in the event of termination by Trubion under Section 9.5 or termination by Wyeth under Section 9.6. To the extent permitted by applicable law, Wyeth shall assign and transfer to 

  
 87 

	 	
Trubion Wyeth’s entire right, title and interest in and to Product Data and Filings, provide copies of all the Research Program Data, and license or otherwise transfer rights to Existing
Trademarks that are necessary or useful for Trubion to continue to research, Develop, Manufacture or Commercialize Licensed Products as constituted at the time of termination. To the extent such Research Program Data, Product Data and Filings and
other rights or items were previously transferred from Trubion to Wyeth, Wyeth shall perform such transfer at no cost to Trubion. To the extent such Research Program Data and Product Data and Filings were not previously transferred from Trubion to
Wyeth, Trubion shall reimburse Wyeth for its reasonable out-of-pocket expenses in connection with such transfer, and such transfer shall be pursuant to an instrument in
form and substance reasonably satisfactory to Trubion. Wyeth shall perform all other actions reasonably requested by Trubion to effect and confirm such transfer. After receipt of Trubion’s request consistent with the foregoing, Wyeth shall
provide to Trubion, within sixty (60) days of receipt of such request, complete copies of such Product Data and Filings, including, without limitation, relevant clinical data, INDs, additional regulatory filings with FDA or other Regulatory
Authorities, supplements or amendments thereto, all written correspondence with FDA or other Regulatory Authorities regarding the regulatory filings, and all existing written minutes of meetings and memoranda of conversations between Wyeth
(including, to the extent practicable, Wyeth’s investigators) and FDA or other Regulatory Authorities in Wyeth’s possession (or in the possession of any of Wyeth’s agents and subcontractors, such as contract research organizations
used by Wyeth), to the extent Wyeth has the right to access and provide to Trubion such Product Data and Filings, regarding such regulatory filings, each to the extent they relate to Licensed Products. Within thirty (30) days (or such later
date as Trubion may request) after the date of receipt of Trubion’s request, Wyeth shall execute and deliver a letter to the FDA or other Regulatory Authorities, in a form approved by Trubion, transferring ownership to Trubion of such
regulatory filings, if any, filed in the name of Wyeth that are related to Licensed Products. 

  

	 	9.7.8.	 Manufacturing of Licensed Products After Termination. If (a) with respect to a particular Licensed
Target, Trubion terminates this Agreement pursuant to Section 9.5 hereof or Wyeth terminates this Agreement pursuant to Section 9.6 hereof, and (b) Wyeth is engaged in the Manufacturing of a Licensed Product directed against such
Licensed Target on the date the terminating Party gives notice of termination under Section 9.5 

  
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or Section 9.6, as the case may be, then Wyeth shall Manufacture such Licensed Product for Trubion and use Commercially Reasonable Efforts to supply Trubion with its entire requirements of
such Licensed Product until (i) the three (3) year anniversary of the effective date of such termination if at the time of such notice there shall have been filed a Regulatory Approval Application for such Licensed Product or (ii) the two
(2) year anniversary of the effective date of such termination if at the time of such notice there shall not have been filed a Regulatory Approval Application for such Licensed Product; provided, however, that (w) Wyeth shall not be
required to conduct any activities to increase the scale on which it is then Manufacturing such Licensed Product, (x) Wyeth shall not be required to Manufacture or supply such Licensed Product in an amount in excess of its available capacity in
the Manufacturing suite that was used by Wyeth for the Manufacture of such Licensed Product (taking into account the other uses Wyeth is making of the manufacturing suite as of the date of the Notice of Termination) or to change the location of the
Manufacturing activities, (y) Wyeth shall have no obligation to maintain idle capacity in such manufacturing suite for purposes of meeting such Manufacturing obligations and (z) Wyeth may at its option assign to Trubion one or more of its
Licensed Product manufacturing agreements with Third Parties, to the extent assignable, in lieu of continuing to contract directly with such Third Parties. The purchase price for such Licensed Product units actually Manufactured by Wyeth shall be at
Wyeth’s fully absorbed manufacturing cost plus twenty percent (20%), and Wyeth’s obligations under this Section 9.7.8 shall be subject to the execution of a supply agreement and a quality agreement, each mutually acceptable to both
Parties, which agreements shall contain the terms set forth in this Section 9.7.8 and such other reasonable terms as mutually agreed by the Parties. 

  

	 	9.7.9.	 Post-Termination Disposition of Inventories of Licensed Products. Following termination of this
Agreement with respect to one or more Licensed Targets, Wyeth and its sublicensees shall have the right to continue to sell their existing inventories of Licensed Products directed against such Licensed Targets for a period not to exceed one hundred
eighty (180) days after the effective date of such termination. Wyeth shall pay royalties and report on such sales, and maintain records thereon, in accordance with Sections 5.4, 5.5 and 5.6, which shall survive termination for such purpose.

  
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	 	9.7.10.	 Continuation of Rights and Licenses Under Sections 6.1.1 and 6.1.2. Notwithstanding anything in this
Section 9.7 to the contrary, the Parties’ rights and licenses set forth in Sections 6.1.1 and 6.1.2 shall survive any expiration or termination of this Agreement. 

 

	 	9.7.11.	 Continuation of Other Rights and Obligations. Except as expressly provided to the contrary in this
Section 9. 7, in the event that a Party exercises any right that results in the termination of some, but not all, of the Parties’ rights and obligations under this Agreement, all non-terminated
rights and obligations of the Parties shall continue in full force and effect. 

  

	 	9.8.	 Modification of Agreement Terms by Wyeth. Without limiting any other legal or equitable remedies that
Wyeth or Trubion may have, subject to Section 11.3, in the event that Wyeth elects to modify the terms of this Agreement as provided in Section 9.5, in lieu of terminating this Agreement under Section 9.5, with respect to one or more
Licensed Targets identified by Wyeth in its Notice of Modification (the “Designated Target(s)”), the following terms shall apply: 

  

	 	9.8.1.	 except as set forth in Section 9.8.4 below, all rights and obligations of the Parties under this Agreement
shall continue in full force and effect, and shall not be subject to any unilateral modification by Wyeth; provided that, if the Designated Target is the CD20 Antigen, Trubion shall have no further option to
Co-Promote CD20 Products under Section 4.11 and the JDC and JPT shall have no further jurisdiction over Licensed Products directed against such CD20 Antigen that is such Designated Target;

  

	 	9.8.2.	 all licenses granted by Trubion to Wyeth under this Agreement with respect to Licensed Products directed
against each Designated Target shall remain in effect; 

  

	 	9.8.3.	 all of the Parties’ rights and obligations under Article 3 in connection with the Research Program shall
cease in their entirety; provided that all amounts due for research performed and costs incurred prior to the date of such termination shall remain payable in accordance with the provisions of Article 3; and 

 

	 	9.8.4.	 only in the event of (i) a material breach by Trubion of Section 2.3.1 or 2.3.2; or (ii) a material
breach by Trubion of Section 8.1(e), 8.2(c) or 8.2(d); or (iii) a material breach by Trubion of Section 8.2(a) (and, in the case of a material breach by Trubion of Section 8.2(a), only where Wyeth establishes that Trubion

  
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had knowledge, as of the Signing Date, that Trubion was not the sole and exclusive owner of the Trubion Patent Rights or that Trubion had placed, or suffered to be placed, any liens, charges or
encumbrances on or against the Trubion Patent Rights); or (iv) if during the term of this Agreement, Trubion grants to a Third Party a right or license that conflicts in a material respect with Wyeth’s then-existing rights under this Agreement
pertaining to such Licensed Target(s), and thereby materially breaches Trubion’s obligations hereunder, then: 

  

	 	(a)	 Wyeth’s diligence obligations to use Commercially Reasonable Efforts under Sections 4.1 and 4.10 shall no
longer apply to Licensed Products directed against such Designated Target; 

  

	 	(b)	 the amount of any Additional Research and Development Expense Payment that Wyeth thereafter becomes obligated
to pay under Section 5.3 relating to Licensed Products directed against such Designated Target shall be reduced by fifty percent (50%) of such amount; and 

 

	 	(c)	 the amounts of any royalties that Wyeth thereafter becomes obligated to pay under Section 5.4 relating to
Licensed Products directed against such Designated Target shall be reduced by fifty percent (50%) of such amounts. 

  

	 	9.9.	 Survival of Certain Obligations. Expiration or termination of this Agreement shall not relieve the
Parties of any obligation accrued or accruing before such expiration or termination (including situations where it becomes clear only after the time of such expiration or termination that such obligation had already accrued). The following
provisions shall survive the expiration or termination of this Agreement: Article 1 (to the extent definitions are embodied in the following listed Articles and Sections); Sections 3.6.3, 3.7, 5.6, 6.1.1, 6.1.2, 9.2, 9.5, 9.6, 9.7, 9.9, 9.10.2,
12.3, 12.6, 12.8, 12.9, 12.10, 12.11 and 12.12; and Articles 7, 10 and 11. Any expiration or early termination of this Agreement shall be without prejudice to the rights of either Party against the other accrued or accruing under this Agreement
before expiration or termination, including, without limitation, the obligations (1) to provide research funding and reimbursement of expenses for activities undertaken prior to such expiration or termination under and in accordance with
Sections 3.6.1, 3.6.2, 4.6, 4.9, 6.1.3, 6.2.1(a), (c) and (d), 6.2.2(b) and (c), and 6.2.3(b) and (c); and (2) to pay royalties for Licensed Products sold before such expiration or termination, and, to the extent permitted under
Section 9.7.9, after expiration or termination in accordance with Section 5.4 (and subject to the related obligations under Section 5.5); and (3) to pay any Additional Research and Development Expense Payments in connection with
any events specified on Exhibit 5.3 that are achieved prior to such expiration or termination, but with respect to which the corresponding payments under Exhibit 5.3 were not paid prior to such expiration or termination.

  
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	 	9.10.	 Change of Control. 

 

	 	9.10.1.	 Definition. With respect to any Party, a “Change of Control” means an event in which:
(a) any other person or group of persons (as the term “person” is used for purposes of Section 13(d) or 14(d) of the Exchange Act) not then beneficially owning more than fifty percent (50%) of the voting power of the outstanding
securities of such Party acquires or otherwise becomes the beneficial owner (within the meaning of Rule 13d-3 promulgated under the Exchange Act) of securities of such Party representing more than fifty
percent (50%) of the voting power of the then outstanding securities of such Party with respect to the election of directors of such Party; or (b) such Person (i) consummates a merger, consolidation or similar transaction with another
Person where the voting securities of such Party outstanding immediately preceding such transaction (or the voting securities issued with respect to the voting securities of such Party outstanding immediately preceding such transaction) represent
less than fifty percent (50%) of the voting power of such Party or surviving entity, as the case may be, immediately following such transaction, (ii) sells or otherwise transfers to any Person(s) in one or more related transactions more than
fifty percent (50%) of its consolidated total assets, or assets from which more than fifty percent (50%) of its consolidated operating income for its most recent financial year was derived, (iii) disposes by sale, assignment, exclusive license
or otherwise of all or substantially all of its intellectual property rights, except for licenses under such intellectual property rights in the ordinary course of business and any isolated sale or assignment of specific items of intellectual
property, or (iv) liquidates, dissolves or winds-up; or (c) with respect to Wyeth and with respect to Trubion, (at any time following any public offering of voting securities by Trubion), any
“person” (as the term “person” is used for the purposes of Sections 13(d) or 14(d) of the Exchange Act) other than Wyeth acquires nineteen and nine-tenths percent (19.9%) or more of the voting power of the then-outstanding voting
securities of such Party. 

  
 92 

	 	9.10.2.	 Change of Control of Wyeth. 

 

	 	(a)	 In the event that any transaction results in a Change of Control of Wyeth, Trubion shall be
entitled to request further written assurances from the successor in interest to Wyeth (the “Successor Party”) re-affirming the commitment of the Successor Party to comply with the terms and
conditions of the Agreement. Such further written assurances shall be delivered within ninety (90) days of written request by Trubion. Trubion may so request at any time during the one-hundred eighty
(180) day period following completion of the subject transaction. Subject to the operation of Section 9.10.2(b) below, the failure of such Successor Party to provide the requested written assurance shall be deemed to be a material breach
of the Agreement. 

  

	 	(b)	 In the event that in connection with, or during the twelve (12) month period following, a Change of
Control of Wyeth, Wyeth or the Successor Party is required, or voluntarily decides, to divest itself of one or more Licensed Products, Wyeth or the Successor Party, subject to any restrictions or limitations imposed by the Federal Trade Commission
or other governmental agency on such divestiture, shall offer to Trubion an exclusive opportunity to negotiate the acquisition or license of all rights of Wyeth or such Successor Party, as the case may be, to such Licensed Product(s) on commercially
reasonable terms. In the event that Trubion and the Successor Party, after ninety (90) days’ good faith negotiations, are unable to conclude a definitive agreement regarding the acquisition or license of such Licensed Product(s), the Successor
Party shall be entitled to divest itself of such Licensed Product(s) to a party other than Trubion; provided, however, no such divestiture to a Third Party shall take place on terms more favorable to such Third Party than those last offered
by the Successor Party to Trubion, without first offering such Licensed Product(s) to Trubion on such more favorable terms. Such Third Party shall be required to assume all of the Successor Party’s obligations owed to Trubion pursuant to this
Agreement with respect to the Licensed Product(s) so divested. 

  

	 	(c)	 In the event of a Change of Control of Wyeth, the restrictive covenants set forth in Sections 2.3.1 and 2.3.2
(the “Exclusivity Covenants”) shall apply to the Successor Party’s then-existing Development and Commercialization activities that otherwise would violate the Exclusivity Covenants (the “Existing Activities”). In such event,
Trubion shall have the right, exercisable upon written notice given by Trubion (an “Exercise Notice”) within thirty (30) days after consummation of the Change of 

  
 93 

 Control, to require such Successor Party to engage in good faith discussions regarding the
terms and conditions on which such Successor Party would pay reasonable financial consideration to Trubion with respect to such Existing Activities. If Trubion and such Successor Party do not agree on such terms and conditions within ninety
(90) days after Trubion gives the Exercise Notice (or such longer period as may be agreed to by such parties), or if such Successor Party notifies Trubion in writing during such ninety (90) day period that it does not desire to engage in
such discussions, Trubion shall have the right, exercisable upon written notice given by Trubion within ten (10) days (i) after the end of such ninety (90) day period (or such longer period as agreed to by such parties) or (ii) after
receipt of such notice from such Successor Party, to require such Successor Party to enter into an agreement to divest to a Third Party either (a) the Existing Activities or (b) the relevant CD20 Products or HER2 Products, as the case may
be (such Third Party, in the case of a divestiture of the relevant CD20 Products or HER2 Products, to be reasonably acceptable to Trubion) within one (1) year after the date of such notice by Trubion, subject to applicable governmental and
regulatory approval. If such Successor Party does not enter into an agreement with a Third Party (such Third Party, in the case of a divestiture of the relevant CD20 Products or HER2 Products, to be reasonably acceptable to Trubion) to divest such
Existing Activities or such Products within such one (1) year period (or if such Successor Party does enter into such an agreement but such agreement terminates after such one (1) year period and such divestiture is not consummated) or if
such Successor Party notifies Trubion in writing that it does not intend to divest such Existing Activities or such Products, Trubion shall have the right, exercisable within (30) days after the end of such one (1) year period (or upon
termination of such agreement, if later) to terminate, in its sole discretion, all CD20-related licenses (only where such Existing Activities relate to products directed against the CD20 Antigen which would otherwise violate Wyeth’s exclusivity
covenants in Section 2.3.1 hereof) and/or all HER2-related licenses (only where such Existing Activities relate to products directed against the HER2 Antigen which would otherwise violate Wyeth’s exclusivity covenants in Section 2.3.2
hereof) granted to Wyeth under the Agreement, on those terms and subject to those conditions that would apply to a termination by Wyeth without cause. 

  
 94 

	 	9.10.3.	 Change of Control of Trubion. In the event of a Change of Control of Trubion where the acquiring party
is a top fifteen (15) pharmaceutical company (measured by market capitalization), Wyeth shall have the right to terminate the Co-Promotion rights of Trubion provided for in Section 4.11 above by
giving written notice to Trubion. 

  

	10.	 INDEMNIFICATION AND INSURANCE. 

 

	 	10.1.	 Indemnification by Wyeth. Wyeth will indemnify, defend and hold harmless Trubion, and each of its
respective employees, officers, directors and agents (each, a “Trubion Indemnified Party”) from and against any and all liability, loss, damage, expense (including reasonable attorneys’ fees and expenses) and cost (collectively,
“Liabilities”) that the Trubion Indemnified Party may be required to pay to one or more Third Parties resulting from or arising out of: 

  

	 	(a)	 any claims of any nature pertaining to any act or omission related to performance under this Agreement by, on
behalf of, or under the authority of Wyeth (other than by any Trubion Indemnified Party) including, but not limited to, research, Development, Manufacture or Commercialization of Licensed Product(s) or any violation of applicable law, rule or
regulation by, on behalf of, or under the authority of Wyeth (other than by any Trubion Indemnified Party); and/or 

  

	 	(b)	 any Wyeth representation or warranty set forth herein being untrue in any material respect when made;

 except in each case, to the extent caused by the negligence or willful misconduct of Trubion or any other Trubion
Indemnified Party. 
  

	 	10.2.	 Indemnification by Trubion. Trubion will indemnify, defend and hold harmless Wyeth and its sublicensees,
distributors and each of its and their respective employees, officers, directors and agents (each, a “Wyeth Indemnified Party”) from and against any and all Liabilities that the Wyeth Indemnified Party may be required to pay to one or more
Third Parties resulting from or arising out of: 

  

	 	(a)	 any claims of any nature pertaining to any act or omission related to performance under this Agreement
by, on behalf of, or under the authority of Trubion (other than by any Wyeth Indemnified Party) or any violation of applicable law, rule or regulation by, on behalf of, or under the authority of Trubion (other than by any Wyeth Indemnified Party);
and/or 

  
 95 

	 	(b)	 any Trubion representation or warranty set forth herein being untrue in any material respect when made;

 except in each case, to the extent caused by the negligence or willful misconduct of Wyeth or any other Wyeth
Indemnified Party. 
  

	 	10.3.	 Procedure. Each Party will notify the other in the event it becomes aware of a claim for which
indemnification may be sought hereunder. In case any proceeding (including any governmental investigation) shall be instituted involving any Party in respect of which indemnity may be sought pursuant to this Article 10, such Party (the
“Indemnified Party”) shall promptly notify the other Party (the “Indemnifying Party”) in writing within fifteen (15) days and the Indemnifying Party and Indemnified Party shall meet to discuss how to respond to any claims that
are the subject matter of such proceeding. The Indemnifying Party, upon request of the Indemnified Party, shall retain counsel reasonably satisfactory to the Indemnified Party to represent the Indemnified Party and shall pay the fees and expenses of
such counsel related to such proceeding. The Indemnified Party agrees to cooperate fully with the Indemnifying Party in the defense of any such claim, action or proceeding, or any litigation resulting from any such claim. In any such proceeding, the
Indemnified Party shall have the right to retain its own counsel, but the fees and expenses of such counsel shall be at the expense of the Indemnified Party unless (a) the Indemnifying Party and the Indemnified Party shall have mutually agreed
to the retention of such counsel or (b) the named parties to any such proceeding (including any impleaded parties) include both the Indemnifying Party and the Indemnified Party and representation of both Parties by the same counsel would be
inappropriate due to actual or potential differing interests between them. All such fees and expenses shall be reimbursed as they are incurred. The Indemnifying Party shall not be liable for any settlement of any proceeding effected without its
written consent, but if settled with such consent or if there be a final judgment for the plaintiff, the Indemnifying Party agrees to indemnify the Indemnified Party from and against any loss or liability by reason of such settlement or judgment.
The Indemnifying Party shall not, without the written consent of the Indemnified Party, effect any settlement of any pending or threatened proceeding in respect of which the Indemnified Party is, or arising out of the same set of facts could have
been, a party and indemnity could have been sought hereunder by the Indemnified Party, unless such settlement includes an unconditional release of the Indemnified Party from all liability on claims that are the subject matter of such proceeding.

  

	 	10.4.	 Insurance. Each Party shall use Commercially Reasonable Efforts to obtain and maintain, during
the term of this Agreement, commercial general liability insurance, including products liability insurance, with reputable and financially secure insurance carriers to cover its indemnification obligations under Sections 10.1 or 10.2, as applicable,
or self-insurance, in each case with limits of not less than Five Million Dollars ($5,000,000.00) per occurrence and in the aggregate. Insurance shall be procured with carriers having an A.M. Best Rating of
A-VII or better. 

  
 96 

	11.	 DISPUTE RESOLUTION. 

 

	 	11.1.	 General. Any controversy, claim or dispute arising out of or relating to this Agreement shall be
settled, if possible, through good faith negotiations between the Parties. If, however, the Parties are unable to settle such dispute after good faith negotiations, the matter shall be referred to the Executive Officers to be resolved by negotiation
in good faith as soon as is practicable but in no event later than thirty (30) days after referral. Such resolution, if any, of a referred issue shall be final and binding on the Parties. 

 

	 	11.2.	 Failure of Executive Officers to Resolve Dispute. If the Executive Officers are unable to settle the
dispute after good faith negotiation in the manner set forth above, either Party (including its successors and permitted assigns but excluding its Affiliates unless an Affiliate is a successor or permitted assign) may seek resolution of the dispute
through any remedies available at law or in equity from any court of competent jurisdiction. 

  

	 	11.3.	 Disclaimer of Consequential and Punitive Damages. Subject to and without limiting the indemnification
obligations of each Party under Article 10, under no circumstances shall either Party be liable to the other Party for consequential or punitive damages arising out of or relating to this Agreement or any breach thereof. Both Parties hereby disclaim
such damages. 

  

	12.	 MISCELLANEOUS. 

 

	 	12.1.	 Periodic Executive Meetings. The Chief Executive Officer of Trubion, the Senior Vice President, Research
and Development of Trubion, the Executive Vice President and General Manager of the Wyeth Pharmaceuticals Biopharma Business Unit and the Executive Vice President and Operating Officer of Wyeth’s Research Division (and such other executive
officers of the Parties as may be designated from time to time by the Parties) shall meet from time to time during the first five (5) years of the term of this Agreement to review and discuss the Parties’ activities under this Agreement.
Such meetings will be held on a quarterly basis or such other periodic basis as such executive officers decide, and will take place in locations selected by such executive officers. Such meetings may take place by telephone or video conference.

  
 97 

	 	12.2.	 Assignment. Neither this Agreement nor any interest hereunder shall be assignable by either Party,
without the prior written consent of the other Party, which consent shall not be unreasonably withheld or delayed, except a Party may make such an assignment without the other Party’s consent to Affiliates or to a successor to substantially all
of the business of such Party to which this Agreement relates, whether in merger, sale of stock, sale of assets or other transaction. This Agreement shall be binding upon the successors and permitted assigns of the Parties, and the name of a Party
appearing herein shall be deemed to include the names of such Party’s successors and permitted assigns to the extent necessary to carry out the intent of this Agreement. In addition to the foregoing, Trubion may assign its right, in whole or
part, to receive payments under this Agreement; provided, however, Trubion shall notify Wyeth of its intention to do so and shall provide Wyeth an opportunity for at least thirty (30) days to negotiate in good faith the purchase
of any such right Trubion intends to so assign. Any assignment not in accordance with this Section 12.2 shall be void. 

  

	 	12.3.	 Further Actions. Each Party agrees to execute, acknowledge and deliver such further instruments, and to
do all such other acts, as may be necessary or appropriate in order to carry out the purposes and intent of the Agreement. 

  

	 	12.4.	 Force Majeure. Neither Party shall be liable to the other for delay or failure in the performance
of the obligations on its part contained in this Agreement if and to the extent that such failure or delay is due to circumstances beyond its control which it could not have avoided by the exercise of reasonable diligence. It shall notify the other
Party promptly should such circumstances arise, giving an indication of the likely extent and duration thereof, and shall use all Commercially Reasonable Efforts to resume performance of its obligations as soon as practicable; provided,
however, that neither Party shall be required to settle any labor dispute or disturbance. 

  

	 	12.5.	 Non-Solicitation. During the period between the Effective Date
and the later of (a) the end of the Research Term or (b) the date on which Trubion completes the activities to be conducted by Trubion pursuant to Section 4.6, but in the case of (a) and (b) not later than the fifth
anniversary of the Effective Date, neither Trubion nor the Wyeth pharmaceuticals business operating in the United States (“U.S. Wyeth Pharmaceuticals”) shall solicit for employment any key or technical employee(s) of the other Party who
become known to U.S. Wyeth Pharmaceuticals or Trubion, as the case may be, through the transactions contemplated by this Agreement without the other’s prior written consent (which consent may be granted or denied in the other’s sole
discretion); provided, however, that nothing in this Section 12.5 shall prohibit U.S. Wyeth Pharmaceuticals or Trubion, as the case may be, from hiring any employees of the other who respond to general employment solicitations not
targeted at the employees of the other, advertised employment opportunities, or hiring by the other by personnel not working on the transactions contemplated by this Agreement or who are not otherwise directly or indirectly exposed to the personnel
working thereon. 

  
 98 

	 	12.6.	 Correspondence and Notices. 

 

	 	12.6.1.	 Ordinary Notices. Correspondence, reports, documentation, and any other communication in writing between
the Parties in the course of ordinary implementation of this Agreement shall be delivered by hand, sent by facsimile transmission (receipt verified), or by airmail to the employee or representative of the other Party who is designated by such other
Party to receive such written communication. 

  

	 	12.6.2.	 Extraordinary Notices. Extraordinary notices and other communications hereunder (including, without
limitation, any notice of force majeure, breach, termination, change of address, etc.) shall be in writing and shall be deemed given if delivered personally or by facsimile transmission (receipt verified), mailed by registered or certified mail
(return receipt requested), postage prepaid, or sent by nationally recognized express courier service, to the Parties at the following addresses (or at such other address for a Party as shall be specified by like notice; provided, however,
that notices of a change of address shall be effective only upon receipt thereof): 

 All correspondence to
Wyeth shall be addressed as follows: 
 Wyeth Pharmaceuticals 

500 Arcola Road 
 Collegeville,
Pennsylvania 19426 
 Attn: Senior Vice President, Corporate Business 

        Development 

Fax: (484) 865-6476 

with a copy to: 
 Wyeth 

5 Giralda Farms 
 Madison, New
Jersey 07940 
 Attn: Executive Vice President and General Counsel 

Fax: (973) 660-7156 

  
 99 

 All correspondence to Trubion shall be addressed as follows: 

Trubion Pharmaceuticals, Inc. 

2401 4th Avenue 
 Suite 1050

 Seattle, Washington 98121 

Attn: President & CEO 

Fax: (206) 838-0503 

with a copy to: 
 Trubion
Pharmaceuticals, Inc. 
 Vice President, Legal Affairs 

2401 4th Avenue 
 Suite 1050

 Seattle, Washington 98121 

Fax: (206) 838-0503 
  

	 	12.7.	 Amendment. No amendment, modification or supplement of any provision of this Agreement shall be valid or
effective unless made in writing and signed by a duly authorized officer of each Party. 

  

	 	12.8.	 Waiver. No provision of the Agreement shall be waived by any act, omission or knowledge of a Party or
its agents or employees except by an instrument in writing expressly waiving such provision and signed by a duly authorized officer of the waiving Party. The waiver by either of the Parties of any breach of any provision hereof by the other Party
shall not be. construed to be a waiver of any succeeding breach of such provision or a waiver of the provision itself. 

  

	 	12.9.	 Severability. If any clause or portion thereof in this Agreement is for any reason held to be invalid,
illegal or unenforceable, the same shall not affect any other portion of this Agreement, as it is the intent of the Parties that this Agreement shall be construed in such fashion as to maintain its existence, validity and enforceability to the
greatest extent possible. In any such event, this Agreement shall be construed as if such clause of portion thereof had never been contained in this Agreement, and there shall be deemed substituted therefor such provision as will most nearly carry
out the intent of the Parties as expressed in this Agreement to the fullest extent permitted by applicable law. 

  

	 	12.10.	 Descriptive Headings. The descriptive headings of this Agreement are for convenience only, and
shall be of no force or effect in construing or interpreting any of the provisions of this Agreement. 

  
 100 

	 	12.11.	 Governing Law. This Agreement shall be governed by and interpreted in accordance with the substantive
laws of the State of New York, without regard to conflict of law principles thereof. 

  

	 	12.12.	 Entire Agreement of the Parties. This Agreement constitutes and contains the complete, final and
exclusive understanding and agreement of the Parties and cancels and supersedes any and all prior negotiations, correspondence, understandings and agreements, whether oral or written, among the Parties respecting the subject matter hereof and
thereof, including, but not limited to, that certain Non-Disclosure Agreement of the Parties effective May 27, 2004. For the avoidance of doubt, disclosures made under such Confidentiality Agreement shall
continue to be subject to the terms of this Agreement as if first disclosed pursuant hereto. Except as expressly set forth in this Agreement, neither Party shall have any other obligations, whether by implication or otherwise, with respect to the
research, Development, Manufacture or Commercialization of Licensed Products. 

  

	 	12.13.	 Independent Contractors. Both Parties are independent contractors under this Agreement. Nothing herein
contained shall be deemed to create an employment, agency, joint venture or partnership relationship between the Parties hereto or any of their agents or employees, or any other legal arrangement that would impose liability upon one Party for the
act or failure to act of the other Party. Neither Party shall have any express or implied power to enter into any contracts or commitments or to incur any liabilities in the name of, or on behalf of, the other Party, or to bind the other Party in
any respect whatsoever. 

  

	 	12.14.	 Counterparts. This Agreement may be executed in any number of counterparts, each of which need not
contain the signature of more than one Party but all such counterparts taken together shall constitute one and the same agreement. Facsimile signatures shall be binding upon the Parties and shall be treated as if originals. 

IN WITNESS WHEREOF, duly authorized representatives of the Parties have duly executed this Agreement to be effective as of the Signing Date.

  

			
	WYETH,
	acting through its
	Wyeth Pharmaceuticals Division
		
	By	 	 

	Name:	 	
	Title:	 	

 

			
	TRUBION PHARMACEUTICALS, INC.
		 	
		 	
		
	By	 	 /s/ Peter A. Thompson

	Name: Peter A. Thompson, M.D.
	Title:   President & CEO

 
 

  
 101 

 EXHIBIT 1.122 

TRU-015 

TRU-015 is the designation for a recombinant chimeric (murine/human) single chain protein that binds
to CD20, a lineage-restricted protein present on the surface of B lymphocytes. TRU-015 is composed of three distinct domains: (1) a binding domain based on the publicly available 2H7 antibody sequence
that binds to human CD20; the heavy and light chain variable regions are connected by a 15-amino acid linker; (2) a modified human IgG1 hinge domain; and (3) an IgG effector domain consisting of the
CH2 and CH3 domains of human IgG1. 
  

TRU-015 Domains 
  

 
 

 
 Monomeric TRU-015 contains 477 amino acid residues resulting in an
approximate theoretical molecular weight of 52,161 Da and a theoretical pl of 8.36. TRU-015 exists as a dimer in solution and has a theoretical weight of 106,000 Da. It exhibits the properties of selective
binding, long half-life, and effector functions. Trubion has termed this type of molecule a “small modular immunopharmaceutical”. 

As of the Signing Date, TRU-015 is investigated in the Phase IIa Clinical Study. 

 EXHIBIT 1.129 

TRUBION PATENT RIGHTS 
  

							
	MOLECULES FOR THERAPY OF B CELL DISEASES	  	United States	  	60/367,358	  	01/17/2001
				
	RECOMBINANT SIGNALING RECEPTORS FOR TUMOR GENE THERAPY	  	United States	  	60/385,691	  	06/03/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	10/053,530	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/088,693	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/088,570	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/089,511	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/089,367	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/088,569	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/089,368	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/089,190	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	11/088,737	  	03/23/2005
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	10/207,655	  	07/25/2002

							
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	United States	  	10/627,556	  	07/26/2003
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	International	  	PCT/US02/01487	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Australia	  	2002241922	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Canada	  	2,433,877	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	China	  	02803820.7	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Europe	  	02707519.1	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Hong Kong	  	03109369.1	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Israel	  	156,955	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Japan	  	2002-557417	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Korea	  	10-2003-7009474	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Mexico	  	PA/a/2003/6358	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	New Zealand	  	527,591	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Poland	  	P364623	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	Russia	  	2003125266	  	01/17/2002

							
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	South Africa	  	2003/5098	  	01/17/2002
				
	BINDING DOMAIN-IMMUNOGLOBULIN FUSION PROTEINS	  	International	  	PCT/US03/24918	  	07/26/2003
				
	BINDING CONSTRUCTS AND METHODS FOR USE THEREOF	  	International	  	PCT/US03/41600	  	12/24/2003
				
	BINDING DOMAIN FUSION PROTEINS (MODULAR GUIDED PROTEASE INHIBITORS (MGPI))	  	United States	  	60/600,755	  	08/11/2004
				
	BINDING DOMAIN FUSION PROTEINS (MODULAR GUIDED PROTEASE INHIBITORS (MGPI))	  	International	  	PCT/US05/28496	  	08/10/2005
				
	SINGLE DOSE USE OF CD20-SPECIFIC BINDING MOLECULES	  	United States	  	60/702,498	  	07/25/2005
				
	SINGLE DOSE USE OF CD20-SPECIFIC BINDING MOLECULES	  	United States	  	60/702,875	  	07/27/2005
				
	COMPOSITIONS AND METHODS FOR PROTEIN DEAGGREGATION	  	United States	  		  	07/25/2005

 EXHIBIT 1.132 

TRUBION THIRD PARTY AGREEMENTS 
 TRU-015 MANUFACTURING AND DEVELOPMENT 
 TRU-015 (V.l) 

 

					
	Manufacturing	    	LONZA	    	 August 12, 2003
 Dev. &
Mfg. Agreement
             Amend 1

            Amend 2

			
		    		    	 January 8, 2004
 Dev. & Mfg.
Agreement
             Amend 1

            Amend 2

            Amend 3

            Amend 4

            Amend 5

            Amend 6

            Amend 7

            Amend 8

            Amend 9

 

	 	 	 
	Formulation	    	 FORMATECH:
 Development of formulation:
liquid and Lypholized
  
	    	Development Agreement Executed
	 	 	 
	Manufacturing	    	 CARDINAL HEALTH:
 Phase II

clinical manufacturing of Lypholized TRU-015
	    	 Consulting Agreement
 Executed

Master Service Agreement

			
		    	Multiple quotes	    	
			
		    	 BAROFOLD, INC.
  
	    	 Evaluation Agreement Executed
  

	 	 	 
	License Agreement	    	CHASINS	    	CHO Cell Lines

 EXHIBIT 1.132 

TRUBION THIRD PARTY AGREEMENTS — Page 2 

TRU-015 MANUFACTURING AND DEVELOPMENT (continued) 
  

 TRU-015 (V.2) 

 

					
	Generate Commercial Cell Line	  	 XCELLEREX:

Tentative Start Date

2/21-2/28

Develop Commercial cell line for TRU-015 (V.2) receive plasmid with DNA
from Trubion and develop through stability testing
	  	 Contract with Workplan in negotiation

 
 Development Services Agreement Executed Amend 1

	 	 	 
	Generate MCB	  	 BIORELIANCE

To generate MCB for Lonza 2006 runs
	  	Completing Master Service Agreement (not yet executed)
	 	 	 
	Manufacturing Agreement	  	 LONZA
 Manufacturing of Commercial Cell
Line
	  	 Lonza Manufacturing
 Service
Agreement

			
		  	Technical transfer to USA site	  	Scale up to 5000L
	 	 	 
	License Agreement	  	CHASINS	  	CHO Cell Lines

 EXHIBIT 1.132 

TRUBION THIRD PARTY AGREEMENTS — Page 3 
  

					
	CLINICAL
			
	CRO	  	PHARMANET, LLC	  	Master Services Agmnt. Executed
			
	CRO	  	KENDLE INTL.	  	Master Services Agmnt. Executed
			
	CRO	  	I3/STRATPROBE	  	 Master Services Agreement
 Exhibit A-1 to MSA
 Exhibit A-2 to MSA Executed

			
	LABORATORY	  	MAYO CLINIC	  	Laboratory Services Agreement Executed
			
	TOXICOLOGY	  	SNBL	  	 Lab Svcs. Agmnt. 01
 Lab Svcs. Agmnt. 04

Lab Svcs. Agmnt. 05
 Lab Svcs. Agmnt. Amend 05

			
		  	             3 Primate Studies

            2 In-vitro Studies
	  	
			
	IMMUNOHISTOCHEMISTRY	  	            PHENOPATH	  	Laboratory Services Agreement
		  		  	(Master Agreement) Executed

  
  

ANALYTICAL 
  

	
	 ANTIBODIES BY DESIGN

(Division of Morphosys)

        Neutralizing Antibodies

 EXHIBIT 1.132 

TRUBION THIRD PARTY AGREEMENTS — Page 4 

RESEARCH 
  

	
	
	 LONZA

	
	 Glutamine-Synthetase (GS) Expression System

	
	 RCT

	
	 Pichia Pastoria Expression System

	
	 XENOGEN

	
	 Transgenic Mice

	
	 SHAMROCK STRUCTURES

	
	 Crystallization and Structural Proteomics

  
  

 

			
	MATERIAL TRANSFER AGREEMENT	  	 FHCRC (Dr. Strong)
 3-D Crystallization

 EXHIBIT 3.2.1 

TRUBION’S “MILESTONE ONE” 

Milestone #1 
 Defined in Trubion’s internal
project management process, which may be modified from time to time. 
 The following specifications are determined: 

 

	 	•	 	 Scientific Rationale that supports the therapeutic potential 

 

	 	•	 	 Mechanism of Action (MOA) 

 

	 	•	 	 Specific biochemical and therapeutic properties (targeted) 

 

	 	•	 	 Binding Domain 

  

	 	•	 	 Target 

  

	 	•	 	 In vivo activity 

 

	 	•	 	 Safety 

  

	 	•	 	 pk 

  

	 	•	 	 Market rationale (preliminary) for product profile 

 

	 	•	 	 Economics (COGs) 

  

	 	•	 	 Clinical rationale (preliminary) for product profile 

 

	 	•	 	 Alliance Opportunity assessment 

 

	 	•	 	 Intellectual property assessment 

 EXHIBIT 3.2.4 

EXCLUDED TARGETS 

GenBank Accession Number (Amino Acid Sequence) 
  

			
		
	L6 (TM4SF1)	  	NP_055035
		
	CD19	  	NP_001761
		
	CD28	  	AAF33792
		
	CD40	  	NP_001241 = isoform 1 (long); NP_690593 = isoform 2 (short)
		
	CD37	  	NP_001765

 EXHIBIT 4.4 

ADVERSE EVENT REPORTING PROCEDURES 

The terms adverse event or experience (AE) and adverse drug reaction (ADR), used in this Exhibit 4.4 shall have the meanings set forth in worldwide reporting
regulations. The Parties agree to comply with any and all governmental laws, regulations and orders that are applicable now and in the future in connection with product safety collection and reporting. 

The Parties agree to meet after the Effective Date to establish a detailed Safety Agreement outlining the pharmacovigilance responsibilities of each Party
including but not limited to: AE or ADR reporting including literature review and associated reporting; AE or ADR follow-up reporting; preparation and submission of all safety reports to the Regulatory
Authorities as required by local laws and/or regulations in the Territory; maintaining the global safety database; all interactions with health authorities regarding safety; periodic submissions; labeling modifications; safety monitoring and
detection; and safety measures (e.g., Dear Doctor Letter, restriction on distribution). Wyeth shall maintain the global safety database for the Licensed Products. 

Notwithstanding the foregoing and until such time as the Safety Agreement is executed, to the extent Trubion has or receives any information regarding any
AE/ADR which may be related to the use of any Licensed Product or to Licensed Product Development, Trubion shall promptly forward such information as follows: 
  

	 	•	 	 Fatal or life-threatening serious AE(s)/ADR(s) judged by either the investigator and/or sponsor to be reasonably
related to the Licensed Product(s) Development/protocol shall be transmitted to Wyeth within three (3) calendar days from the date received by Trubion. 

  

	 	•	 	 All other serious AE(s)/ADR(s) not fatal or life-threatening but judged by either the investigator and/or sponsor
to be reasonably related to the Licensed Product(s) Development/protocol shall be transmitted to Wyeth within five (5) calendar days from the date received by Trubion. 

AE/ADR information may be transmitted to Wyeth by: 
  

	 	a.	 Facsimile: 610-989-5544
or 

  

	 	b.	 Overnight courier to: 

Global Safety Surveillance & Epidemiology 

Wyeth Research 
 GSSE Triage
Unit 
 Dock E 
 500 Arcola
Road 
 Collegeville, PA 19426 

 EXHIBIT 5.2A 

STOCK PURCHASE AGREEMENT 

TRUBION PHARMACEUTICALS, INC. 

COMMON STOCK PURCHASE AGREEMENT 

This Common Stock Purchase Agreement (this “Agreement”) is made as of December     , 2005 by and between
Trubion Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Wyeth, a Delaware corporation (the “Purchaser”). 

RECITALS 

A.    The Purchaser and the Company are entering into a collaboration agreement of even date herewith (the
“Collaboration Agreement”); 
 B.    In connection with the Collaboration Agreement, Purchaser desires
to purchase from the Company shares of its Common Stock (the “Common Stock”), concurrently with and conditioned upon the closing of the Company’s initial public offering, upon the terms and conditions set forth herein; 

C.    The Company and the Purchaser wish to set forth the terms and conditions upon which the Company will sell the Common
Stock to the Purchaser; and 
 D.    Concurrent with the execution of this Agreement, the Company and Purchaser are
entering into an amendment (the “Rights Agreement Amendment”) to the Company’s Amended and Restated Investor Rights Agreement (the “Rights Agreement”) to provide Purchaser with certain rights and obligations
thereunder upon the issuance of the Common Stock hereunder. 
 NOW, THEREFORE, in consideration of the premises and mutual covenants and
conditions contained herein, the Company and the Purchaser hereby agree as follows: 
 ARTICLE 1 

PURCHASE AND SALE OF SHARES 

1.1    Purchase Price and Closing. Subject solely to the conditions set forth in Sections 1.2 – 1.5 and
Article IV hereof, the Company will issue and sell to the Purchaser and, subject to the terms and conditions set forth in this Agreement, the Purchaser will purchase from the Company (the “Sale”), that number of shares of Common
Stock (the “Shares”) equal to the quotient obtained by dividing Twenty- Five Million Dollars ($25,000,000) (the “Investment Amount”) by the per-share price to the public (the
“IPO Price”) of shares of Common Stock in the Company’s first underwritten, firm commitment public offering (the “IPO”) pursuant to an effective registration statement (the “Registration
Statement”) under the Securities Act of 1933, as amended (the “Securities Act”). The per share price to Purchaser shall be the IPO Price. The purchase and sale will take place at a closing (the “Closing”)
to be held on the date, at the location and simultaneously with the closing of the IPO, subject to the satisfaction of all of the conditions to the Closing specified in Article IV herein. At the Closing the Company will issue and deliver a
certificate evidencing the Shares to the Purchaser against payment of the full purchase price therefor by wire transfer of immediately available funds to an account designated by the Company. 

 1.2    Maximum Share Number. Notwithstanding Section 1.1
above, in the event the number of Shares would otherwise constitute more than (i) nineteen and nine-tenths percent (19.9%) of the Actual Voting Power (as defined in Section 5. l(i)) or (ii) twenty percent (20%) of the number of shares
issued in the IPO (including any shares covered by a related registration statement filed pursuant to Rule 462(b) of the Securities Act but excluding any shares issued or to be issued in an overallotment option), then in either case (i) or (ii)
above the Investment Amount (and correspondingly the number of shares purchased by the Purchaser) shall be reduced by the minimum dollar amount and share amount necessary to avoid either such event. 

1.3    Restrictions on Transfer. Pursuant to the Rights Agreement Amendment, Purchaser agrees and acknowledges that
the restrictions set forth in Sections 2.1 and 2.12 of the Rights Agreement shall apply to Purchaser and the Shares. 

1.4    HSR Act. Prior to the execution of the Collaboration Agreement and this Agreement, the parties made certain
filings under the Hart-Scott Rodino Antitrust Improvements Act of 1976, as amended (the “HSR Act”). If either party concludes in good faith that additional filings or proceedings are necessary or desirable as a result of the
transactions contemplated hereby either as a result of the signing of this Agreement or in connection with the Closing or otherwise, the parties agree to promptly file such additional notices, applications and documents that may be required under
the HSR Act, or any other required foreign or domestic competition law (collectively, the “Competition Laws”) and all applicable additional filings fees associated therewith shall be paid by the party required to so pay such
additional filing fees under the applicable Competition Law(s). In connection therewith, the Company and Purchaser each shall use their commercially reasonable efforts to take such actions as may be required to cause the expiration or early
termination of the notice periods under the Competition Laws as promptly as possible and to resolve such objections, if any, as may be asserted with respect to the transactions contemplated by this Agreement under the Competition Laws; provided,
however, that notwithstanding the foregoing, neither party shall agree to any change or amendment to this Agreement unless such change or amendment is agreed by the other party in advance. Nothing in this Agreement shall require either party or
any subsidiary or affiliate of either party to sell, hold separate, license or otherwise dispose of any assets or conduct its business in a specified manner, or agree or proffer to sell, hold separate, license or otherwise dispose of any assets or
conduct its business in a specified manner, or permit or agree to the sale, holding separate, licensing or other disposition of any assets of either party or any subsidiary or affiliate of either party, whether as a condition to obtaining any
approval from, or to avoid potential litigation or administrative action by, a governmental entity or any other person or for any other reason. 

1.5    Termination of Purchase Right and Obligation. Notwithstanding any provision of this Agreement to the
contrary, Purchaser’s right and obligation to purchase, and the Company’s right and obligation to sell, the Shares shall terminate if the closing of the IPO has not occurred prior to the earliest to occur of the following: 

(a)    The termination of the Collaboration Agreement; or 

(b)    The Company (1) undergoes a Change of Control (as defined in Section 5. l(iv));; provided,
however, the following shall be deemed to not be a Change of Control for purposes of this Section 1.5(b): (i) a transaction effected exclusively for the purpose of changing the domicile of the Company, or (ii) an equity financing in
which the Company is the surviving corporation, or (2) engages in a merger, consolidation, reorganization or similar transaction in which the surviving entity has a class of equity securities registered under Section 12 of the Exchange Act
(as defined below). 

  
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 ARTICLE II 

REPRESENTATIONS AND WARRANTIES OF THE COMPANY 

The Company hereby represents and warrants to the Purchaser as follows: 

2.1    Corporate Action. The Company has all necessary corporate power and has taken all corporate action required
to enter into and perform this Agreement and the Rights Agreement Amendment (collectively, the “Financing Documents”). The Financing Documents have been duly executed and delivered, and constitute valid, legal, binding and
enforceable obligations of the Company, enforceable in accordance with their terms, except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of
creditors’ rights generally and (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies. The issuance, sale and delivery of the Shares in accordance with this Agreement
have been duly authorized by all necessary corporate action on the part of the Company. The issuance of the Shares is not subject to preemptive rights or other preferential rights in any present stockholders of the Company that have not been waived
and will not conflict with any provision of any agreement or instrument to which the Company is a party or by which it or its property is bound and to which the Company has not obtained appropriate waivers. 

2.2    No Conflict. The execution and delivery of this Agreement by the Company does not, and the consummation of
the transactions contemplated hereby will not, conflict with, or result in any violation of, or default under (with or without notice or lapse of time, or both), or give rise to a right of termination, cancellation, modification or acceleration of
any obligation under (i) any provision of the Certificate of Incorporation of the Company or Bylaws of the Company, (ii) any material mortgage, indenture, lease, contract or other agreement or instrument, permit, concession, or license to
which the Company or any of its properties or assets is subject or (iii) any judgment, order, decree, applicable to the Company or its properties or assets. To the Company’s knowledge as of the date hereof, no provision of any applicable
law, rule or regulation and no judgment, order, decree or injunction applicable to the Company or its properties or assets shall prohibit the consummation of the Closing nor shall the Closing result in any violation of any such law, rule, regulation
judgment, order, decree or injunction. 
 2.3    Status of Shares. The Shares, when issued and delivered in
accordance with the terms hereof and after payment of the purchase price therefor, will be duly authorized, validly issued, fully-paid and non-assessable, issued in compliance with applicable state and federal
securities laws (subject, in part, to the representations and warranties of Purchase in Article III hereof) and free of restrictions on transfer other than restrictions on transfer under the Financing Documents and applicable state and federal
securities laws. 
 2.4    Organization, Good Standing and Qualification. The Company is a corporation duly
organized, validly existing and in good standing under the laws of the State of Delaware and has all requisite corporate power and authority to carry on its business. 

2.5.    Collaboration Agreement. The Collaboration Agreement has been duly authorized, executed, and delivered by
the Company and constitutes a valid and binding obligation of the Company, enforceable in accordance with its terms, except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application
affecting enforcement of creditors’ rights generally and (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies. 

  
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 2.6    Final Prospectus and Registration Statement. The Company,
acknowledging that the Purchaser will be relying on the accuracy and completeness of the Company’s disclosure in connection with the IPO, warrants to the Purchaser that the Prospectus (as defined below) used in connection with the
Company’s IPO will comply, at the time of filing or use, with the requirements of the Securities Act, and the Prospectus filed or used in connection with the IPO will not, at such time, contain an untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading; the Registration Statement, when it becomes effective, will comply, in all
material respects, with the requirements of the Securities Act; and the Registration Statement will not, when it becomes effective, contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein; provided, however, that the Company makes no warranty with respect to any statement contained in the Registration Statement or a prospectus in reliance upon and in conformity with information
concerning the Purchaser that is furnished by the Purchaser expressly for use therein. “Prospectus” means the final prospectus (as such term is defined in Section 2(a)(10) of the Securities Act) as first filed with the SEC
pursuant to paragraph (1) or (4) of Rule 424(b) of the Securities Act. 
 ARTICLE III 

REPRESENTATIONS AND WARRANTIES AND COVENANTS BY PURCHASER 

The Purchaser represents and warrants and covenants to the Company that: 

3.1    Purchaser is an “accredited investor” as defined in Rule 501(a) under the Securities Act of 1933, as
amended. 
 3.2    Purchaser will acquire the Shares for its own account, for the purpose of investment and not with a
view to distribution or resale thereof. 
 3.3    Purchaser has all necessary corporate power and has taken all
corporate action required to enter into and perform the Financing Documents. The Financing Documents have been duly executed and delivered, and constitute valid, legal, binding and enforceable obligations of Purchaser, enforceable in accordance with
their terms, except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors’ rights generally and (ii) as limited by laws relating to the
availability of specific performance, injunctive relief or other equitable remedies. 
 3.4    Purchaser has taken no
action which would give rise to any claim against the Company by any other person for any brokerage commissions, finders’ fees or the like relating to this Agreement or the transactions contemplated hereby. 

3.5    Purchaser has had the opportunity to ask questions of and receive answers from representatives of the Company
concerning the terms of the offering of the Shares and to obtain additional information concerning the Company and its business. 

3.6    The acquisition by the Purchaser of the Shares shall constitute a confirmation of these representations and
warranties made by the Purchaser as of the Closing. Purchaser understands that the Shares are “restricted securities” under the Securities Act and have not been registered under the Securities Act in reliance upon an exemption for non-public offerings. The Purchaser further represents that it understands and agrees that, until registered under the Securities Act or transferred pursuant to the provisions of Rule 144 as promulgated by the
Commission, all certificates evidencing any of the Shares, whether upon initial issuance or upon any transfer thereof, shall be subject to the transfer restrictions and bear the legends set forth in Section 2.1 of the Rights Agreement. 

  
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 3.7    To the Purchaser’s knowledge as of the date hereof, no
provision of any applicable law, rule or regulation and no judgment, order, decree or injunction applicable to the Purchaser or its properties or assets shall prohibit the consummation of the Closing nor shall the Closing result in any violation of
any such law, rule, regulation, judgment, order, decree or injunction. 
 ARTICLE IV 

CONDITIONS TO CLOSING 

4.1    Conditions of the Purchaser’s Obligation. The obligation of the Purchaser to purchase and pay for the
Shares at the Closing is subject to the satisfaction of the following conditions: 
 (a)    Documentation at
Closing. The Purchaser shall have received prior to or at the Closing all of the following documents or instruments, or evidence of completion thereof, each in form and substance satisfactory to the Purchaser: 

(i)    A copy of the Certificate of Incorporation of the Company, certified by the Secretary of State of the State of
Delaware, a copy of the resolutions of the Board of Directors of the Company evidencing the approval of this Agreement, the issuance of the Shares and the other matters contemplated hereby, and a copy of the Bylaws of the Company, all of which shall
have been certified by the Secretary of the Company to be true, complete and correct in every particular, and certified copies of all documents evidencing other necessary corporate or other action and governmental approvals, if any, with respect to
this Agreement and the Shares. 
 (ii)    A customary opinion of counsel to the Company covering the matters set forth
in Exhibit A hereto. 
 (iii)    A certificate of the Secretary of the Company which shall certify the names of
the officers of the Company authorized to sign this Agreement, the certificate for the Shares and the other documents, instruments or certificates to be delivered pursuant to this Agreement by the Company or any of its officers, together with the
true signatures of such officers. 
 (iv)    A certificate of the President of the Company stating (A) that the
representations and warranties made by the Company in this Agreement are true and correct in all material respects at the date hereof and as of the Closing with the same force and effect as though all such representations and warranties had been
made as of the Closing, and (B) that all covenants and conditions required to be performed prior to or at the Closing have been performed as of the Closing. 

(v)    A Certificate of Good Standing for the Company from the Secretary of State of the State of Delaware, dated as of a
recent date. 
 (b)    Performance. The Company shall have performed and complied with in all material respects
all agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by it on or before the Closing. 

(c)    Consents, Waivers, Etc. The Company shall have obtained all consents or waivers, if any, necessary to
execute and deliver this Agreement, issue the Shares and to carry out the transactions contemplated hereby and thereby and the waiting period applicable to this Agreement and the 

  
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Collaboration Agreement under the HSR Act (or any other applicable Competition Laws) shall have expired or terminated early. All corporate and other action and governmental filings necessary to
effect the terms of this Agreement, the issuance of the Shares and other agreements and instruments executed and delivered by the Company in connection herewith shall have been made or taken, except for any post-sale filing that may be required
under federal or state securities laws. 
 (d)    Rights Agreement Amendment. The Rights Agreement Amendment
shall have been executed by the Company and by the holders of the requisite majority of Registrable Securities (as such term is defined in the Rights Agreement); provided, however, the parties acknowledge that subsequent to the date hereof
the Rights Agreement may be further amended in accordance with its terms; provided, further, however, Purchaser shall be required to consent to such amendment or be provided substantially equivalent rights in such amendment or another written
agreement with the Company. 
 (e)    Collaboration Agreement. The Collaboration Agreement shall have been duly
authorized, executed, and delivered by the Company and constitute a valid and binding obligation of the Company, enforceable in accordance with its terms, except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium
and other laws of general application affecting enforcement of creditors’ rights generally and (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies. The Purchaser shall
not have the right to terminate the Collaboration Agreement for cause pursuant to Section 9.5 thereof (provided, however, if Purchaser’s right to so terminate the Collaboration Agreement for cause is solely dependent on the lapsing
on any applicable “cure” period pursuant to Section 9.5 thereof, solely for purposes of this Section 4.1 (e), Purchaser shall be deemed to have the right to terminate the Collaboration Agreement for cause notwithstanding the
failure of any such cure period to have lapsed); and the Company shall not have given notice to the Purchaser of its intent to terminate the Collaboration Agreement. 

(f)    Representations and Warranties. The representations and warranties made by the Company in this Agreement
shall have been true and correct in all material respects at the date hereof and as of the Closing with the same force and effect as though all such representations and warranties had been made as of the Closing. 

(g)    No Injunctions. No provision of any applicable law, rule or regulation and no judgment, order, decree or
injunction shall prohibit the consummation of the Closing. 
 (h)    Listing. The shares of Common Stock sold in
the IPO shall be listed on the New York Stock Exchange (“NYSE”) or traded on the Nasdaq National Market.    . 

(i)    Closing of IPO. The Closing hereunder shall be concurrent with the closing of the IPO. 

4.2    Conditions of the Company’s Obligation. The obligation of the Company to sell the Shares at the Closing
is subject to the satisfaction of the following conditions: 
 (a)    Performance. The Purchaser shall have
performed and complied with in all material respects all agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by it on or before the Closing. 

(b)    Consents, Waivers, Etc. Any waiting period applicable to this Agreement and the Collaboration Agreement
under the HSR Act (or any other applicable Competition Laws) shall have expired or terminated early. 

  
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 (c)    Rights Agreement Amendment. The Rights Agreement Amendment
shall have been executed by the Purchaser. 
 (d)    Collaboration Agreement. The Collaboration Agreement shall
have been duly authorized, executed and delivered by the Purchaser and constitute a valid and binding obligation of the Purchaser, enforceable in accordance with its terms, subject to laws of general application relating to bankruptcy, insolvency
and the relief of debtors and rules of law governing specific performance, injunctive relief or other equitable remedies. The Company shall not have the right to terminate the Collaboration Agreement for cause pursuant to Section 9.5 thereof
(provided, however, if the Company’s right to so terminate the Collaboration Agreement for cause is solely dependent on the lapsing on any applicable “cure” period pursuant to Section 9.5 thereof, solely for purposes of
this Section 4.2(d), the Company shall be deemed to have the right to terminate the Collaboration Agreement for cause notwithstanding the failure of any such cure period to have lapsed; and the Purchaser shall not have given notice to the
Company of its intent to terminate the Collaboration Agreement. 
 (e)    Representations and Warranties. The
representations and warranties made by the Purchaser in this Agreement shall have been true and correct in all material respects at the date hereof and as of the Closing with the same force and effect as though all such representations and
warranties had been made as of the Closing. 
 (f)    No Injunctions; Applicable Law. No provision of any
applicable law, rule or regulation and no judgment, order, decree or injunction shall prohibit the consummation of the Closing nor shall the Closing result in any violation of any such law, rule, regulation, judgment, order, decree or injunction.

 (g)    Listing. The shares of Common Stock sold in the IPO shall be listed on the NYSE or traded on the Nasdaq
National Market. 
 (h)    Closing of IPO. The Closing hereunder shall be concurrent with the closing of the IPO.

 (i)    Securities Regulations. The sale of the Shares to Purchaser shall not be prohibited under state and
federal securities laws and regulations. 
 ARTICLE V 

STANDSTILL AGREEMENT 

5.1.    Definitions. For the purposes of this Agreement, the following words and phrases shall have the following
meanings: 
 (i)    “Actual Voting Power” means, as of the date of determination, the total number of
votes attaching to the outstanding securities entitled to vote for the election of directors of the Company. 

(ii)    “Affiliate” shall have the meaning given it in Rule 12b-2
under the Securities Exchange Act of 1934, as amended (the “Exchange Act”). 
 (iii)    “Beneficial
Ownership” “Beneficial Owner” and “Beneficially Own” shall have the meanings described to those terms in Rule 13d-1 under the Exchange Act. 

  
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 (iv)    “Change of Control” means (1) the
acquisition by a Third Party of more than 50% of the Company’s then outstanding Voting Securities or (2) the consummation of a merger, acquisition, consolidation or reorganization or series of such related transactions involving the
Company, unless immediately after such transaction or transactions, the Beneficial Owners of the Company immediately prior to the first such transaction shall Beneficially Own at least 50% of the outstanding Voting Securities of the Company (or, if
the Company would not be the surviving company in such merger, consolidation or reorganization, the Voting Securities of the surviving corporation issued in such transaction or transactions in respect of Voting Securities of the Company shall
represent at least 50% of the Voting Securities of such surviving company). 
 (v)    “Investor Group”
means Purchaser and any member of a 13D Group to which the Purchaser belongs. 
 (vi)    “Person” means
an individual, corporation, partnership, association, trust, unincorporated organization or other entity 

(vii)    “13D Group” means any group of persons formed for the purpose of acquiring, holding, voting or
disposing of Voting Securities which would be required under the Exchange Act and the rules and regulations promulgated thereunder, to file a statement on Schedule 13D with the Securities and Exchange Commission as a “person” within the
meaning of Section 13(d)(3) of the Exchange Act if such group beneficially owned sufficient securities to require such a filing under the Exchange Act. 

(viii) “Standstill Period” shall mean the period beginning on the Closing of the IPO and ending on the date that is one year
following the Closing of the IPO. 
 (ix)    “Threshold Percentage” means the percentage of Actual
Voting Power owned by the Purchaser immediately following the closing of the IPO and the sale of Shares hereunder, which in no case shall exceed nineteen and nine-tenths percent (19.9%) of Actual Voting Power. 

(x)    “Third Party” means any Person or two or more Persons acting in concert, other than the Purchaser
and its Affiliates or the Company and its Affiliates. 
 (xii) “Voting Security” means, as of the date of determination,
the Common Stock of the Company, any other security generally entitled to vote for the election of directors and any outstanding convertible securities, options, warrants or other rights which are convertible into or exchangeable or exercisable for
securities entitled to vote for the election of directors. 
 5.2.    Standstill Obligations. 

(a)    Limitation. At any time during the Standstill Period, except with the prior written consent of the
Company’s Board of Directors, no member of the Investor Group shall, directly or indirectly: 
 (i)    acquire any
Voting Securities (except by way of stock splits, stock dividends or other distributions) if the effect of such acquisition or exercise would be to increase the percentage interest of the Investor Group in the Actual Voting Power to more than the
Threshold Percentage; or 
 (ii)    publicly propose (on behalf of itself or to or with a Third Party) any merger,
business combination, restructuring, recapitalization or similar transaction involving the Company or its subsidiaries or the purchase, sale or other disposition outside the ordinary course of business of any material portion of the assets of the
Company or any of its subsidiaries. 

  
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 (b)    Repurchases. Notwithstanding Section 5.2(a), no
member of the Investor Group shall be obligated to dispose of any Voting Securities if the aggregate percentage ownership of the Investor Group is increased as a result of a repurchase of Voting Securities by the Company. 

(c)    Participation. Except with the prior written consent of the Company’s Board of Directors, during the
Standstill Period the Investor Group will not: 
 (i)    solicit proxies (or powers of attorney or similar rights to
vote) in respect of any Voting Securities; 
 (ii)    become a “participant” or “participant in a
solicitation”, as those terms are defined in Regulation 14A of the General Rules and Regulations promulgated pursuant to the Exchange Act, in opposition to a solicitation by the Company; provided, however, that the Investor Group shall
not be deemed to be a “participant” or to have become engaged in a solicitation hereunder solely by reason of the Company’s solicitation of proxies in connection with any meeting of the stockholders of the Company; 

(iii)    seek to advise or intentionally influence any person or entity with respect to the voting of Voting Securities
in connection with any such solicitation, in opposition to the recommendation of a majority of the Board of Directors with respect to any matter relating to a Change of Control; 

(iv)    initiate, propose or otherwise solicit stockholders for the approval of any stockholder proposal (as described in
Rule 14a-8 under the Exchange Act or otherwise) with respect to the Company that is opposed by the Board of Directors; 

(v)    form or join any 13D Group for the purpose of voting, purchasing or disposing of Voting Securities or the
acquisition of all or substantially all of assets of the Company; 
 (vi)    deposit any Voting Securities in a voting
trust or subject them to a voting agreement or other arrangement of similar effect, except in order to comply with Competition Laws or other legal requirements; 

(vii)    otherwise act, alone or in concert with others, in a manner designed or having the deliberate effect of
circumventing the restrictions otherwise imposed hereunder, publicly announce any intention, plan or arrangement inconsistent with the foregoing or finance or agree to finance any other person in connection with any of the activities prohibited by
this Agreement; or 
 (viii) publicly request, propose or otherwise seek any amendment or waiver of the provisions of this Article 5. 

5.3    Exceptions. The limitations provided in Section 5.2 shall immediately terminate upon the occurrence of
any of the following events: 
 (a)    the commencement by any Person (other than a member of the Investor Group or an
Affiliate thereof) of a bona fide tender or exchange offer seeking to acquire Beneficial Ownership of fifty percent (50%) or more of the outstanding shares of Voting Securities of the Company; 

(b)    the execution of an agreement by the Company and any Person which, if consummated, would result in either
(i) a Change of Control of the Company or (ii) the sale of all or substantially all of the Company’s assets; or 

  
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 (c)    the adoption by the Company of a plan of liquidation or
dissolution with respect to the Company. 
 5.4    Exclusion. No action or actions taken by the Purchaser
pursuant to the terms of the Collaboration Agreement or in connection with exercising or enforcing its rights thereunder shall be deemed to violate the restrictions in Section 5.2. 

ARTICLE VI 
 MISCELLANEOUS 

6.1    No Waiver. No failure or delay on the part of any party to this Agreement in exercising any right, power or
remedy hereunder shall operate as a waiver thereof; nor shall any single or partial exercise of any such right, power or remedy preclude any other or further exercise thereof or the exercise of any other right, power or remedy hereunder. None of the
terms, covenants and conditions of this Agreement can be waived except by the written consent of the party waiving compliance. 

6.2    Publicity. The parties may, subject to compliance with the Securities Act, issue a joint press release
announcing this Agreement and the transactions contemplated hereby following execution of this Agreement. Any proposed announcement, press release or other public disclosure concerning this Agreement and/or any of the transactions or relationships
contemplated hereby shall be mutually approved by both parties (which approval shall not be unreasonably withheld); provided, however, that the restrictions contained in this Section 6.2 do not apply to disclosures required by law, the
rules of the NYSE, the NASD or under U.S. generally accepted accounting principles. The Purchaser agrees and acknowledges that this Agreement and the transactions contemplated hereby shall be disclosed in, and filed as an exhibit to, the
Registration Statement. 
 6.3    Amendments, Waivers and Consents. Any provision in this Agreement to the
contrary notwithstanding, and except as hereinafter provided, changes in or additions to this Agreement may be made, and compliance with any covenant or provision set forth herein may be omitted or waived, if the party requesting such change,
addition, omission or waiver shall obtain consent thereto in writing from the other party. Any waiver or consent may be given subject to satisfaction of conditions stated therein and any waiver or consent shall be effective only in the specific
instance and for the specific purpose for which given. Any such amendment or waiver or consent effected in accordance with this Section 6.3 shall be binding upon the parties and their respective successors and assigns. 

6.4    Addresses for Notices. Any notice required or permitted by this Agreement shall be in writing and shall be
deemed sufficient upon receipt, when delivered personally or by courier, overnight delivery service or confirmed facsimile, or seventy-two (72) hours after being deposited in the regular mail as certified
or registered mail (airmail if sent internationally) with postage prepaid, if such notice is addressed to the party to be notified at such party’s address or facsimile number as set forth below, or as subsequently modified by written notice.

 If to the Company: 

Trubion Pharmaceuticals, Inc. 

2401 Fourth Avenue, Suite 1050 

Seattle, WA 98121 
 Attn: Chief
Executive Officer and General Counsel 
 Facsimile Number: (206) 838-0503 

  
 10 

 If to the Purchaser: 

Wyeth Pharmaceuticals 
 500
Arcola Road 
 Collegeville, Pennsylvania 19426 

Attn: Senior Vice President, Corporate Business Development 

Fax: (484) 865-6476 

with a copy to: 
 Wyeth 

5 Giralda Farms 
 Madison, NJ
07940 
 Attn: Executive Vice President and General Counsel 

Facsimile: (973) 660-7156 

6.5    Binding Effect: Assignment. This Agreement may not be assigned by either party without the prior written
consent of the other; provided, however, that the Purchaser may assign its rights and delegate its duties hereunder to an Affiliate without the prior written consent of the Company; provided, however, Purchaser shall remain subject to
Section 5 hereof regardless of any such assignment; and provided further that if the Company undergoes a Change of Control in which (a) the Company is not the surviving entity and (b) this Agreement does not terminate pursuant to
Section 1.5(b) in connection with such Change of Control, the surviving entity and the Purchaser shall enter into a replacement agreement with substantially the same terms as this Agreement. Subject to the foregoing, the terms and conditions of
this Agreement shall inure to the benefit of and be binding upon the respective successors and assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their
respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. 

6.6    Entire Agreement. This Agreement and the documents referred to herein constitute the entire agreement
between the parties and supersede any prior understandings or agreements concerning the subject matter hereof. 

6.7    Specific Performance. The parties acknowledge and agree that irreparable damage would occur in the event any
of the provisions of Article V of this Agreement were not performed in accordance with their specific terms or were otherwise breached. Accordingly, it is agreed that the parties shall be entitled to an injunction or injunctions to prevent or cure
breaches of the provisions of Article V of this Agreement and to enforce specifically the terms and provisions of such Article in any court of the United States or any state thereof having jurisdiction, in addition to any other remedy to which they
may be entitled in law or in equity. 
 6.8    Severability. The provisions of this Agreement are severable and,
in the event that any court of competent jurisdiction shall determine that any one or more of the provisions or part of a provision contained in this Agreement shall, for any reason, be held to be invalid, illegal or unenforceable in any respect,
such invalidity, illegality or unenforceability shall not affect any other provision or part of a provision of this. Agreement; but this Agreement, shall be reformed and construed as if such invalid or illegal or unenforceable provision, or part of
a provision, had never been contained herein, and such provisions or part reformed so that it would be valid, legal and enforceable to the maximum extent possible. 

  
 11 

 6.9    Governing Law. This Agreement shall be governed by, and
construed and enforced in accordance with, the laws of the State of Delaware without reference to Delaware conflicts of law provisions. 

6.10    Headings. Article, Section and subsection headings in this Agreement are included herein for convenience of
reference only and shall not constitute a part of this Agreement for any other purpose. 
 6.11    Counterparts.
This Agreement may be executed in any number of counterparts, each of which shall be enforceable against the party actually executing the counterpart, and all of which together shall constitute one instrument. 

[Signature page follows.] 

  
 12 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the
date first above written. 
  

			
	 TRUBION PHARMACEUTICALS, INC.

		
	By:	 	 /s/ Peter A. Thompson, MD

	Name:	 	Peter A. Thompson, MD
	Title:	 	President & CEO
		
	WYETH	 	
		
	By:	 	 /s/ William M. Haskel

	Name:	 	William M. Haskel
	Title:	 	Vice President

  
 SIGNATURE PAGE TO TRUBION
PHARMACEUTICALS, INC. 
 COMMON STOCK PURCHASE AGREEMENT 

 EXHIBIT A 

MATTERS TO BE COVERED BY COMPANY COUNSEL 

1.    The Company is a corporation validly existing under Delaware law and in good standing with the Secretary of the
State of Delaware and has the corporate power to execute and deliver the Agreement and to perform its obligations thereunder. 

2.    The Company has duly authorized, executed and delivered the Agreement, and the Agreement constitutes the
Company’s valid and binding agreement enforceable against the Company in accordance with its terms, except as enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws relating to or affecting
creditors’ rights generally or by general equitable principles. 
 3.    No consent, approval, authorization or
order of, or any filing or declaration with, any court or governmental agency or body is required in connection with the execution, delivery and performance of the Agreement by the Company or in connection with the taking by the Company of any
action contemplated thereby, other than as indicated in the Agreement or such as have been obtained and made and such as may be required under federal and state securities laws. 

4.    The execution, delivery and performance of the Agreement by the Company, and the consummation by the Company of the
transactions contemplated therein do not and will not (a) violate the Certificate of Incorporation or By-Laws of the Company, (b) materially violate any judgment, ruling, decree or order known to
such counsel, (c) materially violate any statute or regulation applicable to the business or properties of the Company, or (d) result in a material breach or violation of any of the terms or provisions of, or constitute a default or result
in the acceleration of any obligation under any material contract to which the Company is a party or bound. 
 5.    The
Shares delivered on the date hereof have been duly authorized and validly issued and are fully paid and non-assessable shares of the Company. 

 Execution Copy 

EXHIBIT 5.2B 

TRUBION PHARMACEUTICALS, INC. 

AMENDMENT NO. 1 TO 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

This Amendment No. 1 to the Amended and Restated Investor Rights Agreement (the “Rights Agreement”) dated as of
July 13, 2004 is entered into as of             , 2005, by and among Trubion Pharmaceuticals, Inc., a Delaware corporation (the “Company”), Wyeth, a Delaware
corporation (“Wyeth”), and the investors set forth on Exhibit A hereto (collectively the “Investors” and each individually an “Investor”). 

RECITALS 

A.     The Company and the Investors are parties to the Rights Agreement. 

B.     The Company and Wyeth have entered into a Common Stock Purchase Agreement dated as of
December    , 2005 (the “Purchase Agreement”) pursuant to which the Company will sell to Purchaser and Purchaser will purchase from the Company shares of the Company’s Common Stock concurrent with and
conditioned upon the closing of the Company’s initial public offering (the “Closing”). A condition to the Purchaser’s obligations under the Purchase Agreement is that the Rights Agreement be amended in order to provide
Purchaser with certain rights to register shares of the Company’s Common Stock. 
 C.     Pursuant to
Section 6.5 of the Rights Agreement, the written consent of the Company and the Investors holding a majority of the Registrable Securities (the “Requisite Holders”) is required to amend the Rights Agreement. 

D.     The Company and the Requisite Holders desire to induce Purchaser to enter into the Purchase Agreement by agreeing
to the terms and conditions set forth herein. 
 NOW, THEREFORE, in consideration of the mutual promises, representations,
warranties, covenants and conditions set forth in this Agreement, the parties hereto agree as follows: 
 1.    
Definitions. Capitalized terms used herein without definition shall have the meaning ascribed to them in the Rights Agreement. 

2.     Addition of Purchaser as a Party to the Rights Agreement. Effective upon the Closing pursuant to the
Purchase Agreement, the parties hereby agree to add Purchaser as a party to the Rights Agreement and Purchaser shall be deemed a “Holder” of Registrable Securities for purposes of Sections 1, 2 and 6 of the Rights Agreement and subject to
all of the rights and obligations of such Sections. For purposes of clarification, Purchaser shall not be entitled to the rights or subject to the obligations set forth in Sections 3, 4 and 5 of the Rights Agreement and Purchaser shall not be deemed
an “Investor” for purposes of the Rights Agreement. 

 Execution Copy 

3.     Amendment to Section 1.1. The definition of “Registrable Securities” set forth in
Section 1.1 is hereby amended and restated to read in its entirety as follows: 
 “Registrable
Securities” means (a) Common Stock of the Company issued or issuable upon conversion of the Shares, (b) Common Stock of the Company issued to Frazier Healthcare Fund (“Frazier”), ARCH Venture
Fund (“Arch”) and Scott Minick (“Minick”) pursuant to those certain Common Stock Purchase Agreements dated November 19, 2002 by and between the Company and each of Frazier, Arch and Minick, (c) Common
Stock of the Company issued to Wyeth pursuant to the Purchase Agreement, and (d) any Common Stock of the Company issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or
other distribution with respect to, or in exchange for or in replacement of, the securities described in (a), (b) and (c) above; provided, however, the shares referred to in clause (c) above shall not qualify as Registrable
Securities for the purposes of Sections 2.2 hereof until the 15 month anniversary of the Closing. For the avoidance of doubt, in the event that the Company effects a registration under the Securities Act pursuant to Section 2.2 hereof prior to
the 15 month anniversary of the Closing, in connection with such registration the Shares referred to in clause (c) above shall qualify as Registrable Securities for the purposes of Section 2.3. Notwithstanding the foregoing, Registrable
Securities shall not include any securities sold by a person to the public pursuant to a registration statement or Rule 144 or sold in a private transaction in which the transferor’s rights under Section 2 of this Agreement are not
assigned. 
 4.     Amendment to Section 2.1(a)(ii). Section 2.1(a)(ii) is amended effective
immediately following the expiration of the “Market Stand-Off’ period set forth in Section 2.12 hereof, by deleting the last sentence thereof and substituting therefor the following: 

“Subject to the other terms of this Agreement (including without limitation the restrictions on assignment of registration rights set
forth in Section 2.10 and Sections 2.1(b) and (d)), it is agreed that the restrictions contained in this Section 2.1(a)(ii) shall not apply to dispositions of Shares or Registrable Securities made pursuant to Rule 144 promulgated under the
Securities Act.” 
 5.     Amendment to Section 6.5. Section 6.5 is hereby amended by adding,
after the final sentence thereof, the following: 
 Notwithstanding the foregoing, neither this Agreement nor any term hereof may be
amended, waived, discharged or terminated in any way that diminishes or eliminates the rights particular to Wyeth hereunder and in a manner different than the other holders of Registrable Securities, such action shall require the prior written
consent of Wyeth. 
 6.     Waiver of Right of Participation. Each Investor on behalf of itself and all other
Investors and holders of Registrable Securities hereby waives any right of participation set forth in Section IV of the Rights Agreement with respect to the sale and issuance of the shares of Company Common Stock to Wyeth pursuant to the Purchase
Agreement. 
 7.     No Other Amendments. Except as expressly amended or waived as set forth above, the Rights
Agreement shall remain in full force and effect in accordance with its terms. 
 8.     Counterparts. This
Amendment may be executed in any number of counterparts, each of which shall be deemed an original and all of which together shall constitute one document. 

  
 -2- 

 Execution Copy 

[Signature pages follow.] 

  
 -3- 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO THE
RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“COMPANY”
	
	TRUBION PHARMACEUTICALS, INC.
	a Delaware corporation
		
	By:	 	/s/ Peter Thompson
		 	Peter Thompson, M.D., FACP
		 	President and Chief Executive officer

 SIGNATURE PAGE TO AMENDMENT NO. 1 TO 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT
NO. 1 TO THE RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“WYETH”
	
	WYETH
		
	By:	 	 /s/ William M. Haskel

			
	Name:	 	 William M. Haskel

	Its:	 	 Vice President

 SIGNATURE PAGE TO AMENDMENT NO. 1
TO 
 AMENDED AND RESTATED INVESTOR RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO THE
RIGHT AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTOR”
	
	Prospect Venture partners II, L.P.
	
	By: Prospect Management Co. II, LLC,
	Its General Partner

 
			
		
	By:	 	 /s/ David Schnell

			
	Name:	 	David Schnell
	Title:	 	Managing Member

  

			
	Prospect Associates II, L.P.
	
	By: Prospect Management Co. II, LLC,
	Its General Partner

 
			
		
	By:	 	 /s/ David Schnell

			
	Name:	 	David Schnell
	Title:	 	Managing Member

  
 SIGNATURE PAGE TO
AMENDMENT NO. 1 TO 
 AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO THE
RlGHT’S AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTOR”
	
	ARCH Venture Fund V, L.P.
		
	By:	 	ARCH Venture Partners V,L.P.
		 	Its general partner
		
	By:	 	ARCH Venture Partners V, L.L.C.
		 	Its general partner
		
	By:	 	 

  

	Title:	 	Managing Director
	
	ARCH V Entrepreneurs Fund, L.P.
		
	By:	 	ARCH Venture Partners V,L.P.
		 	Its general partner
		
	By:	 	ARCH Venture Partners V, L.L.C.
		 	Its general partner
		
	By:	 	 

  

	Title:	 	Managing Director
	
	Healthcare Focus Fund, L.P.
		
	By:	 	ARCH Venture Partners V,L.P.
		 	Its general partner
		
	By:	 	ARCH Venture Partners V, L.L.C.
		 	Its general partner
		
	By:	 	 

  

	Title:	 	Managing Director

 SIGNATURE PAGE TO AMENDMENT NO. 1 TO 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties here to have executed this AMENDMENT NO. 1 TO THE
RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 
  

					
	“INVESTOR”
	
	Oxford Bioscience Partners IV L.P.
		
	By:	 	OBP Management IV L.P.
		
	By:	 	 /s/ Mark P. Carthy

		 		 	Mark P. Carthy – General Partner

 
			
	
	mRNA Fund II L.P. 
		
	 By:
	 	OBP Management IV L.P.
		
	 By:
	 	 /s/ Mark P. Carthy

		 	Mark P. Carthy – General Partner

  
 SIGNATURE PAGE TO
AMENDMENT NO. 1 TO 
 AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT
NO. 1 TO THE RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTOR”

 
			
	
	Frazier Healthcare IV, L.P.
	
	By FHM IV, LP, its general partner
	By FHM IV, LLC, its general partner

 
			
		
	By:	 	 /s/ Patrick Heron

			
		
	Name:	 	 Patrick Heron

 
			
		
	Its:	 	 authorized representative

			
	
	Frazier Affiliates IV, L.P.
	
	By FHM IV, LP, its general partner
	By FHM IV, LLC, its general partner

 
			
		
	By:	 	 /s/ Patrick Heron

			
		
	Name:	 	 Patrick Heron

 
			
		
	Its:	 	 authorized representative

			
	
	Frazier Healthcare III, L.P.
	
	By FHM III, LLC

 
			
		
	By:	 	  

 
			
		
	Name:	 	  

 
			
		
	Its:	 	  

 
			
	
	Frazier Affiliates III, L.P.
	
	By FHM III, LLC

 
			
		
	By:	 	  

 
			
		
	Name:	 	  

 
			
		
	Its:	 	  

 SIGNATURE PAGE TO AMENDMENT NO. 1
TO 
 AMENDED AND RESTATED INVESTOR RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties here to have executed this AMENDMENT NO. 1 TO THE
RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTOR”
	
	 Frazier Healthcare IV, L.P.

By FHM IV, LP, its general partner
 By FHM IV, LLC, its general
partner

 
			
		
	By:	 	 

 
			
		
	Name:	 	 

 
			
		
	Its:	 	 

  

			
	 Frazier Affiliates IV, L.P.

By FHM IV, LP, its general partner
 By FHM IV, LLC, its general
partner

 
			
		
	By:	 	 

 
			
		
	Name:	 	 

 
			
		
	Its:	 	 

  

			
	 Frazier Healthcare III, L.P.

By FHM III, LLC

 
			
		
	By:	 	

 
			
		
	Name:	 	 

 
			
		
	Its:	 	 

  

			
	 Frazier Affiliates III, L.P.

By FHM III, LLC

 
			
		
	By:	 	

 
			
		
	Name:	 	 

 
			
		
	Its:	 	 

 SIGNATURE PAGE TO AMENDMENT NO. 1
TO 
 AMENDED AND RESTATED INVESTOR RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO THE
RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTORS”
	
	VENROCK PARTNERS, L.P.
	 by its General Partner, Venrock Partners
Management, LLC

	
	VENROCK ASSOCIATES IV, L.P.
	 by its General Partner, Venrock Management IV, LLC

	
	VENROCK ENTREPRENEURS FUND IV, L.P.
	 by its General Partner, VEF Management IV, LLC

		
	By:	 	/s/ Anders D. Hove
	Name:	 	Anders D. Hove
	Title:	 	Member
	Address:	 	 30 Rockefeller Plaza
 Room 5508

New York, NY 10112

 SIGNATURE PAGE TO AMENDMENT NO. 1 TO 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO THE RIGHTS AGREEMENT
as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTORS”
	
	ATP Capital, L.P.
		
	By:	 	ATP General Partner LLC
		 	Its General Partner
		
	By:	 	 
		 	Jonathan Malkin, Manager

 SIGNATURE PAGE TO AMENDMENT NO. 1 TO 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO THE RIGHTS AGREEMENT
as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTOR”
	
	Cascade Investments, L.L.C.

 
			
		
	By:	 	 

 
			
		
	 Name:
	 	 

 
			
		
	 Its:
	 	
	
	 

  
 2 

 IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO THE RIGHTS
AGREEMENT as of the date set forth in the first paragraph hereof. 
  

			
	“INVESTOR”
	
	 

 
			
		
	By:	 	 

 
			
		
	 Name:
	 	 

 
			
		
	 Its:
	 	
	
	 

 SIGNATURE PAGE TO AMENDMENT NO. 1 TO 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

 EXHIBIT 5.3 

ADDITIONAL RESEARCH AND DEVELOPMENT 

EXPENSE PAYMENTS 
 A. Additional
Research and Development Expense Payments for CD20 Products 
 Within thirty (30) days after Trubion’s or Wyeth’s achievement of the
following events with respect to any CD20 Product (each payable one time only even if achieved with respect to more than one CD20 Product), Wyeth shall make the following payments to Trubion: 

 

					
	 Initiation of dosing in the first Phase IIb Clinical Study for rheumatoid arthritis:
	  	$	5.0 million	 
	 Initiation of dosing in the first Phase III Clinical Study for the first Niche
Indication:
	  	$	2.5 million	 
	 Initiation of dosing in the first Phase III Clinical Study for the first Major
Indication:
	  	$	12.5 million	 
	 Initiation of dosing in the first Phase III Clinical Study for the second Major
Indication:
	  	$	10.0 million	 
	 BLA filing and acceptance for review in the U.S. for the first Niche Indication:
	  	$	3.0 million	 
	 BLA filing and acceptance for review in the U.S. for the first Major Indication:
	  	$	20.0 million	 
	 BLA filing and acceptance for review in the U.S. for the second Major Indication:
	  	$	10.0 million	 
	 Committee for Medicinal Products for Human Use (“CHMP”) or equivalent registration
filing and acceptance for review in Europe for the first Niche Indication either in a centralized filing or a filing in France, Germany, Italy, Spain or the U.K.:
	  	$	1.0 million	 
	 CHMP or equivalent registration filing and acceptance for review in Europe for the first Major
Indication either in a centralized filing or a filing in France, Germany, Italy, Spain or the U.K.:
	  	$	3.0 million	 

					
	 CHMP or equivalent registration filing and acceptance for review in Europe for the second Major
Indication either in a centralized filing or a filing in France, Germany, Italy, Spain or the U.K.:
	  	$	2.0 million	 
	 Registration filing and acceptance for review in Japan for the first Niche Indication:
	  	$	1.0 million	 
	 Registration filing and acceptance for review in Japan for the first Major Indication:
	  	$	3.0 million	 
	 Registration filing and acceptance for review in Japan for the second Major Indication:
	  	$	2.0 million	 
	 U.S. FDA approval for the first Niche Indication:
	  	$	5.0 million	 
	 First Commercial Sale in the U.S. for the first Major Indication:
	  	$	40.0 million	 
	 First Commercial Sale in the U.S. for the second Major Indication:
	  	$	20.0 million	 
	 First Commercial Sale in Europe for the first Niche Indication (divided equally among France,
Germany, Italy, Spain and the U.K.):
	  	$	2.5 million	 
	 First Commercial Sale in Europe for the first Major Indication (divided equally among France,
Germany, Italy, Spain and the U.K.):
	  	$	6.0 million	 
	 First Commercial Sale in Europe for the second Major Indication (divided equally among France,
Germany, Italy, Spain and the U.K.):
	  	$	4.0 million	 
	 First Commercial Sale in Japan for the first Niche Indication:
	  	$	2.5 million	 
	 First Commercial Sale in Japan for the first Major Indication:
	  	$	6.0 million	 
	 First Commercial Sale in Japan for the second Major Indication:
	  	$	4.0 million	 

  
 2 

					
	 The first achievement of $1.0 billion in annual Net Sales of CD20 Products in any calendar
year, provided that such event occurs within ten (10) years after the first launch of a CD20 Product in a Major Indication in a Major Market Country:
	  	$	10.0 million	 
	 The first achievement of $2.5 billion in annual Net Sales of CD20 Products in any calendar
year, provided that such event occurs within ten (10) years after the first launch of a CD20 Product in a Major Indication in a Major Market Country:
	  	$	25.0 million	 
	 The first achievement of $5.0 billion in annual Net Sales of CD20 Products in any calendar
year, provided that such event occurs within ten (10) years after the first launch of a CD Product in a Major Indication in a Major Market Country:
	  	$	50.0 million	 

 B. Additional Research and Development Expense Payments for
HER2 Products 
 Within thirty (30) days after Wyeth’s achievement of the following events with respect to any HER2 Product (each payable one
time only even if completed or achieved with respect to more than one HER2 Product), Wyeth shall make the following payments to Trubion: 
  

					
	 Initiation of dosing in the first Phase I Clinical Study:
	  	$	2.0 million	 
	 Initiation of dosing in the first Phase II Clinical Study:
	  	$	3.0 million	 
	 Initiation of dosing in the first Phase III Clinical Study:
	  	$	5.0 million	 
	 BLA filing and acceptance for review in the U.S.:
	  	$	15.0 million	 
	 CHMP or equivalent registration filing and acceptance for review in Europe either in a centralized
filing or a filing in France, Germany, Italy, Spain or the U.K.:
	  	$	10.0 million	 
	 Registration filing and acceptance for review in Japan:
	  	$	5.0 million	 
	 First Commercial Sale in the U.S.:
	  	$	30.0 million	 
	 First Commercial Sale in Europe (divided equally among France, Germany, Italy and the
U.K.):
	  	$	20.0 million	 

  
 3 

					
	 First Commercial Sale in Japan:
	  	$	10.0 million	 
	 The first achievement of $1.0 billion in annual Net Sales of HER2 Products in any calendar
year, provided that such event occurs within ten (10) years after the first launch of an HER2 Product anywhere in the Territory:
	  	$	10.0 million	 
	 The first achievement of $2.5 billion in annual Net Sales of HER2 Products in any calendar
year, provided that such event occurs within ten (10) years after the first launch of an HER2 Product anywhere in the Territory:
	  	$	25.0 million	 

 C. Additional Research and Development Expense Payments for
Other Products 
 Within thirty (30) days after Wyeth’s achievement of the following events with respect to each Other Product (up to a maximum
of ten (10) Other Products), Wyeth shall make the following payments to Trubion; provided, however, that: (i) in the event that any of the following events is achieved with respect to two or more Other Products that are
directed against the same Wyeth Target, such payment shall be payable only with respect to the first such Other Product for which the event occurred; and (ii) in the event that an Other Product is directed against two or more Wyeth Targets,
such Licensed Product shall be a Multispecific SMIP Product, the consequences of which are as described in Section D below: 
  

					
	 Initiation of dosing in the first Phase I Clinical Study:
	  	$	1.0 million	 
	 Initiation of dosing in the first Phase II Clinical Study:
	  	$	1.5 million	 
	 Initiation of dosing in the first Phase III Clinical Study:
	  	$	2.5 million	 
	 BLA filing and acceptance for review in the U.S.:
	  	$	5.0 million	 
	 CHMP or equivalent registration filing and acceptance for review in Europe (either in a
centralized filing or a filing in France, Germany, Italy, Spain and the U.K.):
	  	$	5.0 million	 
	 Registration filing and acceptance for review in Japan:
	  	$	2.0 million	 
	 First Commercial Sale in the U.S.:
	  	$	10.0 million	 
	 First Commercial Sale in Europe (divided equally among France, Germany, Italy and the
U.K.):
	  	$	10.0 million	 
	 First Commercial Sale in Japan:
	  	$	3.0 million	 

  
 4 

 D. No Additional Payments; Other Applicable Terms and Conditions 

(i) Other than the payments listed in Sections A—C of this Exhibit 5.3, no Additional Research and Development Expense Payments shall be due or payable by
Wyeth to Trubion for any Licensed Product, regardless of the number of Licensed Products Developed against any Trubion Target or Wyeth Target. 
 (ii) Each
of the Additional Research and Development Expense Payments set forth above shall be payable one time only with respect to each Licensed Target (regardless of the number of times the specified event is achieved with respect to any Licensed
Product(s)). 
 (iii) In the event that the Development of a Licensed Product directed against a particular Licensed Target hereunder (an “Initial
Licensed Product”) is discontinued prior to the Commercialization of such Initial Licensed Product, and Development has been initiated with respect to another Licensed Product directed against such Licensed Target (a “Replacement Licensed
Product”), payments with respect to such Replacement Licensed Product shall be due under this Exhibit 5.3 only upon the achievement of those events that have not been achieved by the Initial Licensed Product. 

(iv) Without limiting the foregoing, if a specified event listed in Sections A—C of this Exhibit 5.3 occurs with respect to a Licensed Product directed
against two or more Licensed Targets (a “Multispecific SMIP Product”), then (a) no more than one Additional Research and Development Expense Payment shall become payable with respect to the achievement of such event for such
Multispecific SMIP Product, (b) only the highest Additional Research and Development Expense Payment based on the achievement of such event that has not already become payable shall be payable, and (c) if all Additional Research and
Development Expense Payments based on the achievement of such event have already become payable, then no payment shall be due with respect to such event for such Multispecific SMIP Product. By way of example only, if a BLA filing and acceptance for
review in the U.S. occurs with respect to a Multispecific SMIP Product directed against the HER2 Antigen and a Wyeth Target (“Wyeth Target Q”), then: (x) if the $15.0 million Additional Research and Development Expense Payment
under Section B for such event has not already become payable, only such $15.0 million amount shall become payable; (y) if such $15.0 million Additional Research and Development Expense Payment had already become payable, then the
$5.0 million Additional Research and Development Expense Payment under Section C for such event shall become payable, if it has not previously become payable; and, (z) if both such $15.0 million and such $5.0 million Additional
Research and Development Expense Payment had previously become payable, then no payment shall be due upon BLA filing and acceptance for review in the U.S. with respect to such Multispecific SMIP Product. To continue the same 

  
 5 

 
example, if the same Multispecific SMIP Product meets the condition set forth in (x) above, and thereafter a BLA filing and acceptance for review in the U.S. occurs with respect to a
separate Licensed Product directed only against such Wyeth Target Q, then upon such subsequent occurrence by such separate Licensed Product, the $5.0 million Additional Research and Development Expense Payment shall be payable with
respect to such Wyeth Target Q (if such $5.0 million payment had not previously become payable in connection with Wyeth Target Q). 
 (v)
Subject to the limitations set forth above in Sections A, B and C and in this Section D, if an Additional Research and Development Expense Payment based on a clinical study of, or Regulatory Approval filing for, a Licensed Product for a particular
indication (a “Later Development Event”) becomes payable before the achievement of an earlier phase clinical study event with respect to such Licensed Product for the same indication for which Additional Research and Development Expense
Payments would have been payable (an “Earlier Development Event”), then the Additional Research and Development Expense Payment for the Earlier Development Event also shall become payable upon occurrence of the Later Development Event. By
way of example only, if the FDA permits a BLA filing for a HER2 Product on the basis of Phase II Clinical Study results without requiring a Phase III Clinical Study, the Additional Research and Development Expense Payments for such BLA filing (when
made and accepted for review) and for a Phase III Clinical Study of such HER2 Product shall become payable at the same time. 

  
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 EXHIBIT 8.2(d) 

THIRD PARTY RIGHTS 

[Intentionally Left Blank] 

 EXHIBIT 8.2(e) 

GOVERNMENT FUNDING AGREEMENTS 

NIH Grant # 5 R01 CA90143 

Project Title: Gene Therapy with MAB Derivatives Expressed on Tumors

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