Document:

EX-4.8

 Exhibit 4.8 

PERSONALIS, INC. 
 AND

                     , AS
WARRANT AGENT 
 FORM OF DEBT SECURITIES 

WARRANT AGREEMENT 
 DATED
AS OF                      

 PERSONALIS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT 

THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [●], between
PERSONALIS, INC., a Delaware corporation (the “Company”), and [●], a [corporation] [national banking association] organized and existing under the laws of [●] and having a corporate trust office in
[●], as warrant agent (the “Warrant Agent”). 
 WHEREAS, the Company has entered into an indenture
dated as of [●] (the “Indenture”), with [●], as trustee (such trustee, and any successors to such trustee, herein called the “Trustee”), providing for the issuance from time to time of its
debt securities, to be issued in one or more series as provided in the Indenture (the “Debt Securities”); 

WHEREAS, the Company proposes to sell [If Warrants are sold with other securities — [title of such
other securities being offered] (the “Other Securities”) with] warrant certificates evidencing one or more warrants (the “Warrants” or, individually, a “Warrant”) representing
the right to purchase [title of Debt Securities purchasable through exercise of Warrants] (the “Warrant Debt Securities”), such warrant certificates and other warrant certificates issued pursuant to this Agreement being
herein called the “Warrant Certificates”; and 
 WHEREAS, the Company desires the Warrant Agent to act
on behalf of the Company, and the Warrant Agent is willing so to act, in connection with the issuance, registration, transfer, exchange, exercise and replacement of the Warrant Certificates, and in this Agreement wishes to set forth, among other
things, the form and provisions of the Warrant Certificates and the terms and conditions on which they may be issued, registered, transferred, exchanged, exercised and replaced. 

NOW THEREFORE, in consideration of the premises and of the mutual agreements herein contained, the parties hereto agree as
follows: 
 ARTICLE 1 

ISSUANCE OF WARRANTS AND EXECUTION AND 

DELIVERY OF WARRANT CERTIFICATES 

1.1    Issuance of Warrants. [If Warrants alone — Upon issuance, each
Warrant Certificate shall evidence one or more Warrants.] [If Other Securities and Warrants — Warrant Certificates will be issued in connection with the issuance of the Other Securities but shall be separately transferable and
each Warrant Certificate shall evidence one or more Warrants.] Each Warrant evidenced thereby shall represent the right, subject to the provisions contained herein and therein, to purchase one Warrant Debt Security. [If Other Securities and
Warrants — Warrant Certificates will be issued with the Other Securities and each Warrant Certificate will evidence [●] Warrants for each [$[●] principal amount] [[●] shares] of Other Securities issued.] 

1.2    Execution and Delivery of Warrant Certificates. Each Warrant Certificate,
whenever issued, shall be in registered form substantially in the form set forth in Exhibit A hereto, shall be dated the date of its countersignature by the Warrant Agent and may have such letters, numbers, or other marks of identification or
designation and such legends or endorsements printed, lithographed or engraved thereon as the officers of the Company executing the same may approve (execution thereof to be conclusive evidence of such approval) and as are not inconsistent with the
provisions of this Agreement, or as may be required to comply with any law or with any rule or regulation made pursuant thereto or with any rule or regulation of any securities exchange on which the Warrants may be listed, or to conform to usage.
The Warrant Certificates shall be signed on behalf of the Company by any of its present or future chief executive 

  
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officers, presidents, senior vice presidents, vice presidents, chief financial officers, chief legal officers, treasurers, assistant treasurers, controllers, assistant controllers, secretaries or
assistant secretaries under its corporate seal reproduced thereon. Such signatures may be manual or facsimile signatures of such authorized officers and may be imprinted or otherwise reproduced on the Warrant Certificates. The seal of the Company
may be in the form of a facsimile thereof and may be impressed, affixed, imprinted or otherwise reproduced on the Warrant Certificates. 

No Warrant Certificate shall be valid for any purpose, and no Warrant evidenced thereby shall be exercisable, until such Warrant Certificate
has been countersigned by the manual signature of the Warrant Agent. Such signature by the Warrant Agent upon any Warrant Certificate executed by the Company shall be conclusive evidence that the Warrant Certificate so countersigned has been duly
issued hereunder. 
 In case any officer of the Company who shall have signed any of the Warrant Certificates either manually or by
facsimile signature shall cease to be such officer before the Warrant Certificates so signed shall have been countersigned and delivered by the Warrant Agent, such Warrant Certificates may be countersigned and delivered notwithstanding that the
person who signed such Warrant Certificates ceased to be such officer of the Company; and any Warrant Certificate may be signed on behalf of the Company by such persons as, at the actual date of the execution of such Warrant Certificate, shall be
the proper officers of the Company, although at the date of the execution of this Agreement any such person was not such officer. 
 The
term “holder” or “holder of a Warrant Certificate” as used herein shall mean any person in whose name at the time any Warrant Certificate shall be registered upon the books to be maintained by the
Warrant Agent for that purpose. 
 1.3    Issuance of Warrant Certificates. Warrant
Certificates evidencing the right to purchase Warrant Debt Securities may be executed by the Company and delivered to the Warrant Agent upon the execution of this Agreement or from time to time thereafter. The Warrant Agent shall, upon receipt of
Warrant Certificates duly executed on behalf of the Company, countersign such Warrant Certificates and shall deliver such Warrant Certificates to or upon the order of the Company. 

ARTICLE 2 
 WARRANT
PRICE, DURATION AND EXERCISE OF WARRANTS 
 2.1    Warrant Price. During the period specified in
Section 2.2, each Warrant shall, subject to the terms of this Agreement and the applicable Warrant Certificate, entitle the holder thereof to purchase the principal amount of Warrant Debt Securities specified in the applicable Warrant
Certificate at an exercise price of [●]% of the principal amount thereof [plus accrued amortization, if any, of the original issue discount of the Warrant Debt Securities] [plus accrued interest, if any, from the most recent date from which
interest shall have been paid on the Warrant Debt Securities or, if no interest shall have been paid on the Warrant Debt Securities, from the date of their initial issuance.] [The original issue discount ($[●] for each $1,000 principal amount
of Warrant Debt Securities) will be amortized at a [●]% annual rate, computed on a[n] [semi-] annual basis [using a 360-day year consisting of twelve 30-day
months].] Such purchase price for the Warrant Debt Securities is referred to in this Agreement as the “Warrant Price.” 

2.2    Duration of Warrants. Each Warrant may be exercised in whole or in part at any
time, as specified herein, on or after [the date thereof] [●] and at or before [●] p.m., [City] time, on [●] or such later date as the Company may designate by notice to the Warrant Agent and the holders of Warrant Certificates
mailed to their addresses as set forth in the record books of the Warrant Agent (the “Expiration Date”). Each Warrant not exercised at or before [●] p.m., [City] time, on the Expiration Date shall become void, and all
rights of the holder of the Warrant Certificate evidencing such Warrant under this Agreement shall cease. 

  
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 2.3    Exercise of Warrants. 

(a)    During the period specified in Section 2.2, the Warrants may be exercised to purchase a whole number of
Warrant Debt Securities in registered form by providing certain information as set forth on the reverse side of the Warrant Certificate and by paying in full, in lawful money of the United States of America, [in cash or by certified check or
official bank check in New York Clearing House funds] [by bank wire transfer in immediately available funds] the Warrant Price for each Warrant Debt Security with respect to which a Warrant is being exercised to the Warrant Agent at its corporate
trust office, provided that such exercise is subject to receipt within five business days of such payment by the Warrant Agent of the Warrant Certificate with the form of election to purchase Warrant Debt Securities set forth on the reverse side of
the Warrant Certificate properly completed and duly executed. The date on which payment in full of the Warrant Price is received by the Warrant Agent shall, subject to receipt of the Warrant Certificate as aforesaid, be deemed to be the date on
which the Warrant is exercised; provided, however, that if, at the date of receipt of such Warrant Certificates and payment in full of the Warrant Price, the transfer books for the Warrant Debt Securities purchasable upon the exercise of such
Warrants shall be closed, no such receipt of such Warrant Certificates and no such payment of such Warrant Price shall be effective to constitute the person so designated to be named as the holder of record of such Warrant Debt Securities on such
date, but shall be effective to constitute such person as the holder of record of such Warrant Debt Securities for all purposes at the opening of business on the next succeeding day on which the transfer books for the Warrant Debt Securities
purchasable upon the exercise of such Warrants shall be opened, and the certificates for the Warrant Debt Securities in respect of which such Warrants are then exercised shall be issuable as of the date on such next succeeding day on which the
transfer books shall next be opened, and until such date the Company shall be under no duty to deliver any certificate for such Warrant Debt Securities. The Warrant Agent shall deposit all funds received by it in payment of the Warrant Price in an
account of the Company maintained with it and shall advise the Company by telephone at the end of each day on which a payment for the exercise of Warrants is received of the amount so deposited to its account. The Warrant Agent shall promptly
confirm such telephone advice to the Company in writing. 
 (b)    The Warrant Agent shall, from time to time, as
promptly as practicable, advise the Company of (i) the number of Warrant Debt Securities with respect to which Warrants were exercised, (ii) the instructions of each holder of the Warrant Certificates evidencing such Warrants with respect
to delivery of the Warrant Debt Securities to which such holder is entitled upon such exercise, (iii) delivery of Warrant Certificates evidencing the balance, if any, of the Warrants for the remaining Warrant Debt Securities after such
exercise, and (iv) such other information as the Company or the Trustee shall reasonably require. 

(c)    As soon as practicable after the exercise of any Warrant, the Company shall issue pursuant to the Indenture,
in authorized denominations, to or upon the order of the holder of the Warrant Certificate evidencing such Warrant the Warrant Debt Securities to which such holder is entitled, in fully registered form, registered in such name or names as may be
directed by such holder. If fewer than all of the Warrants evidenced by such Warrant Certificate are exercised, the Company shall execute, and an authorized officer of the Warrant Agent shall manually countersign and deliver, a new Warrant
Certificate evidencing Warrants for the number of Warrant Debt Securities remaining unexercised. 
 (d)    The
Company shall not be required to pay any stamp or other tax or other governmental charge required to be paid in connection with any transfer involved in the issue of the Warrant Debt Securities, and in the event that any such transfer is involved,
the Company shall not be required to issue or deliver any Warrant Debt Securities until such tax or other charge shall have been paid or it has been established to the Company’s satisfaction that no such tax or other charge is due. 

  
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 (e)    Prior to the issuance of any Warrants there shall have
been reserved, and the Company shall at all times through the Expiration Date keep reserved, out of its authorized but unissued Warrant Debt Securities, a number of shares sufficient to provide for the exercise of the Warrants. 

ARTICLE 3 
 OTHER
PROVISIONS RELATING TO RIGHTS OF HOLDERS OF 
 WARRANT CERTIFICATES 

3.1    No Rights as Holder of Warrant Debt Securities Conferred by Warrants
or Warrant Certificates. No Warrant Certificate or Warrant evidenced thereby shall entitle the holder thereof to any of the rights of a holder of Warrant Debt Securities, including, without limitation, the right to receive
the payment of principal of (or premium, if any) or interest, if any, on the Warrant Debt Securities or to enforce any of the covenants in the Indenture. 

3.2    Lost, Stolen, Mutilated or Destroyed Warrant Certificates. Upon receipt by the
Warrant Agent of evidence reasonably satisfactory to it and the Company of the ownership of and the loss, theft, destruction or mutilation of any Warrant Certificate and/or indemnity reasonably satisfactory to the Warrant Agent and the Company and,
in the case of mutilation, upon surrender of the mutilated Warrant Certificate to the Warrant Agent for cancellation, then, in the absence of notice to the Company or the Warrant Agent that such Warrant Certificate has been acquired by a bona fide
purchaser, the Company shall execute, and an authorized officer of the Warrant Agent shall manually countersign and deliver, in exchange for or in lieu of the lost, stolen, destroyed or mutilated Warrant Certificate, a new Warrant Certificate of the
same tenor and evidencing Warrants for a like principal amount of Warrant Debt Securities. Upon the issuance of any new Warrant Certificate under this Section 3.2, the Company may require the payment of a sum sufficient to cover any tax or
other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses of the Warrant Agent) in connection therewith. Every substitute Warrant Certificate executed and delivered pursuant to this
Section 3.2 in lieu of any lost, stolen or destroyed Warrant Certificate shall represent an additional contractual obligation of the Company, whether or not the lost, stolen or destroyed Warrant Certificate shall be at any time enforceable by
anyone, and shall be entitled to the benefits of this Agreement equally and proportionately with any and all other Warrant Certificates duly executed and delivered hereunder. The provisions of this Section 3.2 are exclusive and shall preclude
(to the extent lawful) all other rights and remedies with respect to the replacement of mutilated, lost, stolen or destroyed Warrant Certificates. 

3.3    Holder of Warrant Certificate May Enforce Rights. Notwithstanding any of
the provisions of this Agreement, any holder of a Warrant Certificate, without the consent of the Warrant Agent, , the Trustee, the holder of any Warrant Debt Securities or the holder of any other Warrant Certificate, may, in such holder’s own
behalf and for such holder’s own benefit, enforce, and may institute and maintain any suit, action or proceeding against the Company suitable to enforce, or otherwise in respect of, such holder’s right to exercise the Warrants evidenced by
such holder’s Warrant Certificate in the manner provided in such holder’s Warrant Certificates and in this Agreement. 

3.4    Merger, Sale, Conveyance or Lease. In case of (a) any share exchange, merger or similar
transaction of the Company with or into another person or entity (other than a share exchange, merger or similar transaction in which the Company is the acquiring or surviving corporation) or (b) the sale, exchange, lease, transfer or other
disposition of all or substantially all of the properties and assets of the Company as an entirety (in any such case, a “Reorganization Event”), then, as a condition of such 

  
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Reorganization Event, lawful provisions shall be made, and duly executed documents evidencing the same from the Company’s successor shall be delivered to the holders of the Warrants, so that
such successor shall succeed to and be substituted for the Company, and assume all the Company’s obligations under, this Agreement and the Warrants. The Company shall thereupon be relieved of any further obligation hereunder or under the
Warrants, and the Company as the predecessor corporation may thereupon or at any time thereafter be dissolved, wound up or liquidated. Such successor or assuming entity thereupon may cause to be signed, and may issue either in its own name or in the
name of the Company, any or all of the Warrants issuable hereunder which heretofore shall not have been signed by the Company, and may execute and deliver securities in its own name, in fulfillment of its obligations to deliver Warrant Debt
Securities upon exercise of the Warrants. All the Warrants so issued shall in all respects have the same legal rank and benefit under this Agreement as the Warrants theretofore or thereafter issued in accordance with the terms of this Agreement as
though all of such Warrants had been issued at the date of the execution hereof. In any case of any such Reorganization Event, such changes in phraseology and form (but not in substance) may be made in the Warrants thereafter to be issued as may be
appropriate. The Warrant Agent may receive a written opinion of legal counsel as conclusive evidence that any such Reorganization Event complies with the provisions of this Section 3.4. 

3.5    Notice to Warrant Holders. In case the Company shall (a) effect any Reorganization
Event or (b) make any distribution on or in respect of the [title of Warrant Debt Securities] in connection with the dissolution, liquidation or winding up of the Company, then the Company shall mail to each holder of Warrants at such
holder’s address as it shall appear on the books of the Warrant Agent, at least ten days prior to the applicable date hereinafter specified, a notice stating the date on which such Reorganization Event, dissolution, liquidation or winding up is
expected to become effective, and the date as of which it is expected that holders of [title of Warrant Debt Securities] of record shall be entitled to exchange their shares of [title of Warrant Debt Securities] for securities or other property
deliverable upon such Reorganization Event, dissolution, liquidation or winding up. No failure to mail such notice nor any defect therein or in the mailing thereof shall affect any such transaction. 

ARTICLE 4 
 EXCHANGE AND
TRANSFER OF WARRANT CERTIFICATES 
 4.1    Exchange and Transfer of
Warrant Certificates. Upon surrender at the corporate trust office of the Warrant Agent, Warrant Certificates evidencing Warrants may be exchanged for Warrant Certificates in other denominations evidencing such Warrants or the transfer
thereof may be registered in whole or in part; provided that such other Warrant Certificates evidence Warrants for the same aggregate principal amount of Warrant Debt Securities as the Warrant Certificates so surrendered. The Warrant Agent shall
keep, at its corporate trust office, books in which, subject to such reasonable regulations as it may prescribe, it shall register Warrant Certificates and exchanges and transfers of outstanding Warrant Certificates, upon surrender of the Warrant
Certificates to the Warrant Agent at its corporate trust office for exchange or registration of transfer, properly endorsed or accompanied by appropriate instruments of registration of transfer and written instructions for transfer, all in form
satisfactory to the Company and the Warrant Agent. No service charge shall be made for any exchange or registration of transfer of Warrant Certificates, but the Company may require payment of a sum sufficient to cover any stamp or other tax or other
governmental charge that may be imposed in connection with any such exchange or registration of transfer. Whenever any Warrant Certificates are so surrendered for exchange or registration of transfer, an authorized officer of the Warrant Agent shall
manually countersign and deliver to the person or persons entitled thereto a Warrant Certificate or Warrant Certificates duly authorized and executed by the Company, as so requested. The Warrant Agent shall not be required to effect any exchange or
registration of transfer which will result in the issuance of a Warrant Certificate evidencing a Warrant for a fraction of a Warrant Debt Security or a number of Warrants for a whole number of Warrant Debt Securities and a fraction of a

  
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Warrant Debt Security. All Warrant Certificates issued upon any exchange or registration of transfer of Warrant Certificates shall be the valid obligations of the Company, evidencing the same
obligations and entitled to the same benefits under this Agreement as the Warrant Certificate surrendered for such exchange or registration of transfer. 

4.2    Treatment of Holders of Warrant Certificates. The
Company, the Warrant Agent and all other persons may treat the registered holder of a Warrant Certificate as the absolute owner thereof for any purpose and as the person entitled to exercise the rights represented by the Warrants evidenced
thereby, any notice to the contrary notwithstanding. 
 4.3    Cancellation of Warrant
Certificates. Any Warrant Certificate surrendered for exchange, registration of transfer or exercise of the Warrants evidenced thereby shall, if surrendered to the Company, be delivered to the Warrant Agent and all Warrant Certificates
surrendered or so delivered to the Warrant Agent shall be promptly canceled by the Warrant Agent and shall not be reissued and, except as expressly permitted by this Agreement, no Warrant Certificate shall be issued hereunder in exchange therefor or
in lieu thereof. The Warrant Agent shall deliver to the Company from time to time or otherwise dispose of canceled Warrant Certificates in a manner satisfactory to the Company. 

ARTICLE 5 
 CONCERNING
THE WARRANT AGENT 
 5.1    Warrant Agent. The Company hereby appoints [●] as Warrant Agent of
the Company in respect of the Warrants and the Warrant Certificates upon the terms and subject to the conditions herein set forth, and [●] hereby accepts such appointment. The Warrant Agent shall have the powers and authority granted to and
conferred upon it in the Warrant Certificates and hereby and such further powers and authority to act on behalf of the Company as the Company may hereafter grant to or confer upon it. All of the terms and provisions with respect to such powers and
authority contained in the Warrant Certificates are subject to and governed by the terms and provisions hereof. 

5.2    Conditions of Warrant Agent’s Obligations. The Warrant Agent
accepts its obligations herein set forth upon the terms and conditions hereof, including the following to all of which the Company agrees and to all of which the rights hereunder of the holders from time to time of the Warrant Certificates shall be
subject: 
 (a)    Compensation and Indemnification. The Company agrees promptly to pay the
Warrant Agent the compensation to be agreed upon with the Company for all services rendered by the Warrant Agent and to reimburse the Warrant Agent for reasonable
out-of-pocket expenses (including reasonable counsel fees) incurred without negligence, bad faith or willful misconduct by the Warrant Agent in connection with the
services rendered hereunder by the Warrant Agent. The Company also agrees to indemnify the Warrant Agent for, and to hold it harmless against, any loss, liability or expense incurred without negligence, bad faith or willful misconduct on the part of
the Warrant Agent, arising out of or in connection with its acting as Warrant Agent hereunder, including the reasonable costs and expenses of defending against any claim of such liability. 

(b)    Agent for the Company. In acting under this Agreement and in connection
with the Warrant Certificates, the Warrant Agent is acting solely as agent of the Company and does not assume any obligations or relationship of agency or trust for or with any of the holders of Warrant Certificates or beneficial owners of Warrants.

  
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 (c)    Counsel. The Warrant Agent may consult with counsel
satisfactory to it, which may include counsel for the Company, and the written advice of such counsel shall be full and complete authorization and protection in respect of any action taken, suffered or omitted by it hereunder in good faith and in
accordance with the advice of such counsel. 
 (d)    Documents. The Warrant Agent shall be protected and
shall incur no liability for or in respect of any action taken or omitted by it in reliance upon any Warrant Certificate, notice, direction, consent, certificate, affidavit, statement or other paper or document reasonably believed by it to be
genuine and to have been presented or signed by the proper parties. 
 (e)    Certain Transactions. The
Warrant Agent, and its officers, directors and employees, may become the owner of, or acquire any interest in, Warrants, with the same rights that it or they would have if it were not the Warrant Agent hereunder, and, to the extent permitted by
applicable law, it or they may engage or be interested in any financial or other transaction with the Company and may act on, or as depositary, trustee or agent for, any committee or body of holders of Warrant Debt Securities or other obligations of
the Company as freely as if it were not the Warrant Agent hereunder. Nothing in this Agreement shall be deemed to prevent the Warrant Agent from acting as trustee under any indenture to which the Company is a party, including, without limitation, as
Trustee under the Indenture. 
 (f)    No Liability for Interest. Unless otherwise agreed
with the Company, the Warrant Agent shall have no liability for interest on any monies at any time received by it pursuant to any of the provisions of this Agreement or of the Warrant Certificates. 

(g)    No Liability for Invalidity. The Warrant Agent shall have no liability with respect to
any invalidity of this Agreement or any of the Warrant Certificates (except as to the Warrant Agent’s countersignature thereon). 

(h)    No Responsibility for Representations. The Warrant Agent shall not be responsible for
any of the recitals or representations herein or in the Warrant Certificates (except as to the Warrant Agent’s countersignature thereon), all of which are made solely by the Company. 

(i)    No Implied Obligations. The Warrant Agent shall be obligated to perform only such duties as are
herein and in the Warrant Certificates specifically set forth and no implied duties or obligations shall be read into this Agreement or the Warrant Certificates against the Warrant Agent. The Warrant Agent shall not be under any obligation to take
any action hereunder which may tend to involve it in any expense or liability, the payment of which within a reasonable time is not, in its reasonable opinion, assured to it. The Warrant Agent shall not be accountable or under any duty or
responsibility for the use by the Company of any of the Warrant Certificates authenticated by the Warrant Agent and delivered by it to the Company pursuant to this Agreement or for the application by the Company of the proceeds of the Warrant
Certificates. The Warrant Agent shall have no duty or responsibility in case of any default by the Company in the performance of its covenants or agreements contained herein or in the Warrant Certificates or in the case of the receipt of any written
demand from a holder of a Warrant Certificate with respect to such default, including, without limiting the generality of the foregoing, any duty or responsibility to initiate or attempt to initiate any proceedings at law or otherwise or, except as
provided in Section 6.2 hereof, to make any demand upon the Company. 

  
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 5.3    Resignation, Removal and Appointment of Successors. 

(a)    The Company agrees, for the benefit of the holders from time to time of the Warrant Certificates, that there
shall at all times be a Warrant Agent hereunder until all the Warrants have been exercised or are no longer exercisable. 

(b)    The Warrant Agent may at any time resign as agent by giving written notice to the Company of such intention
on its part, specifying the date on which its desired resignation shall become effective; provided that such date shall not be less than three months after the date on which such notice is given unless the Company otherwise agrees. The Warrant Agent
hereunder may be removed at any time by the filing with it of an instrument in writing signed by or on behalf of the Company and specifying such removal and the intended date when it shall become effective. Such resignation or removal shall take
effect upon the appointment by the Company, as hereinafter provided, of a successor Warrant Agent (which shall be a bank or trust company authorized under the laws of the jurisdiction of its organization to exercise corporate trust powers) and the
acceptance of such appointment by such successor Warrant Agent. The obligation of the Company under Section 5.2(a) shall continue to the extent set forth therein notwithstanding the resignation or removal of the Warrant Agent. 

(c)    In case at any time the Warrant Agent shall resign, or shall be removed, or shall become incapable of
acting, or shall be adjudged a bankrupt or insolvent, or shall commence a voluntary case under the Federal bankruptcy laws, as now or hereafter constituted, or under any other applicable Federal or state bankruptcy, insolvency or similar law or
shall consent to the appointment of or taking possession by a receiver, custodian, liquidator, assignee, trustee, sequestrator (or other similar official) of the Warrant Agent or its property or affairs, or shall make an assignment for the benefit
of creditors, or shall admit in writing its inability to pay its debts generally as they become due, or shall take corporate action in furtherance of any such action, or a decree or order for relief by a court having jurisdiction in the premises
shall have been entered in respect of the Warrant Agent in an involuntary case under the Federal bankruptcy laws, as now or hereafter constituted, or any other applicable Federal or state bankruptcy, insolvency or similar law, or a decree or order
by a court having jurisdiction in the premises shall have been entered for the appointment of a receiver, custodian, liquidator, assignee, trustee, sequestrator (or similar official) of the Warrant Agent or of its property or affairs, or any public
officer shall take charge or control of the Warrant Agent or of its property or affairs for the purpose of rehabilitation, conservation, winding up or liquidation, a successor Warrant Agent, qualified as aforesaid, shall be appointed by the Company
by an instrument in writing, filed with the successor Warrant Agent. Upon the appointment as aforesaid of a successor Warrant Agent and acceptance by the successor Warrant Agent of such appointment, the Warrant Agent shall cease to be Warrant Agent
hereunder. 
 (d)    Any successor Warrant Agent appointed hereunder shall execute, acknowledge and deliver to
its predecessor and to the Company an instrument accepting such appointment hereunder, and thereupon such successor Warrant Agent, without any further act, deed or conveyance, shall become vested with all the authority, rights, powers, trusts,
immunities, duties and obligations of such predecessor with like effect as if originally named as Warrant Agent hereunder, and such predecessor, upon payment of its charges and disbursements then unpaid, shall thereupon become obligated to transfer,
deliver and pay over, and such successor Warrant Agent shall be entitled to receive, all monies, securities and other property on deposit with or held by such predecessor, as Warrant Agent hereunder. 

(e)    Any corporation into which the Warrant Agent hereunder may be merged or converted or any corporation with
which the Warrant Agent may be consolidated, or any corporation resulting from any merger, conversion or consolidation to which the Warrant Agent shall be a party, or any corporation to which the Warrant Agent shall sell or otherwise transfer all or
substantially all the assets and business of the Warrant Agent, provided that it shall be qualified as aforesaid, shall be the successor Warrant Agent under this Agreement without the execution or filing of any paper or any further act on the part
of any of the parties hereto. 

  
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 ARTICLE 6 

MISCELLANEOUS 

6.1    Amendment. This Agreement may be amended by the parties hereto, without the consent of the holder of
any Warrant Certificate, for the purpose of curing any ambiguity, or of curing, correcting or supplementing any defective provision contained herein, or making any other provisions with respect to matters or questions arising under this Agreement as
the Company and the Warrant Agent may deem necessary or desirable; provided that such action shall not materially adversely affect the interests of the holders of the Warrant Certificates. 

6.2    Notices and Demands to the Company and Warrant Agent.
If the Warrant Agent shall receive any notice or demand addressed to the Company by the holder of a Warrant Certificate pursuant to the provisions of the Warrant Certificates, the Warrant Agent shall promptly forward such notice or demand to the
Company. 
 6.3    Addresses. Any communication from the Company to the Warrant Agent with respect to this
Agreement shall be addressed to [●], Attention: [●] and any communication from the Warrant Agent to the Company with respect to this Agreement shall be addressed to Personalis, Inc., 1330 O’Brien Drive, Menlo Park, CA 94025,
Attention: [●] (or such other address as shall be specified in writing by the Warrant Agent or by the Company). 

6.4    Governing Law. This Agreement and each Warrant Certificate issued hereunder shall be governed by and
construed in accordance with the laws of the State of New York. 
 6.5    Delivery of
Prospectus. The Company shall furnish to the Warrant Agent sufficient copies of a prospectus meeting the requirements of the Securities Act of 1933, as amended, relating to the Warrant Debt Securities deliverable upon exercise of the
Warrants (the “Prospectus”), and the Warrant Agent agrees that upon the exercise of any Warrant, the Warrant Agent will deliver to the holder of the Warrant Certificate evidencing such Warrant, prior to or concurrently with
the delivery of the Warrant Debt Securities issued upon such exercise, a Prospectus. The Warrant Agent shall not, by reason of any such delivery, assume any responsibility for the accuracy or adequacy of such Prospectus. 

6.6    Obtaining of Governmental Approvals. The Company will from time to time take all action
which may be necessary to obtain and keep effective any and all permits, consents and approvals of governmental agencies and authorities and securities act filings under United States Federal and state laws (including without limitation a
registration statement in respect of the Warrants and Warrant Debt Securities under the Securities Act of 1933, as amended), which may be or become requisite in connection with the issuance, sale, transfer, and delivery of the Warrant Debt
Securities issued upon exercise of the Warrants, the issuance, sale, transfer and delivery of the Warrants or upon the expiration of the period during which the Warrants are exercisable. 

  
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 6.7    Persons Having Rights under the Agreement. Nothing
in this Agreement shall give to any person other than the Company, the Warrant Agent and the holders of the Warrant Certificates any right, remedy or claim under or by reason of this Agreement. 

6.8    Headings. The descriptive headings of the several Articles and Sections of this Agreement are
inserted for convenience only and shall not control or affect the meaning or construction of any of the provisions hereof. 

6.9    Counterparts. This Agreement may be executed in any number of counterparts, each of which as so
executed shall be deemed to be an original, but such counterparts shall together constitute but one and the same instrument. 

6.10    Inspection of Agreement. A copy of this Agreement shall be available at all reasonable
times at the principal corporate trust office of the Warrant Agent for inspection by the holder of any Warrant Certificate. The Warrant Agent may require such holder to submit such holder’s Warrant Certificate for inspection by it. 

  
 10 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly
executed as of the day and year first above written. 
  

			
	PERSONALIS, INC., as Company

 
			
		
	By:	 	  

 
			
	Name:	 	  

 
			
	Title:	 	  

 
			
		
	ATTEST:	 	  

 
			
		 	  

 
			
	
	COUNTERSIGNED

 
			
	
	[●], as Warrant Agent

 
			
		
	By:	 	  

 
			
	Name:	 	  

 
			
	Title:	 	  

 
			
		
	ATTEST:	 	  

 
			
		 	  

 [SIGNATURE PAGE TO PERSONALIS, INC. DEBT SECURITIES WARRANT AGREEMENT] 

 EXHIBIT A 

FORM OF WARRANT CERTIFICATE 

[FACE OF WARRANT CERTIFICATE] 
  

			
	[Form of Legend if Warrants are not immediately exercisable.]	  	[Prior to [●], Warrants evidenced by this Warrant Certificate cannot be exercised.]

 EXERCISABLE ONLY IF COUNTERSIGNED BY THE WARRANT AGENT AS PROVIDED HEREIN 

VOID AFTER [●] P.M., [City] time, ON [●]. 

 PERSONALIS, INC. 

WARRANT CERTIFICATE REPRESENTING 

WARRANTS TO PURCHASE 

[TITLE OF WARRANT DEBT SECURITIES] 
  

			
	No. [●]	  	[●] Warrants

 This certifies that [●] or registered assigns is the registered owner of the above indicated number of Warrants, each
Warrant entitling such owner to purchase, at any time [after [●] p.m., [City] time, [on [●] and] on or before [●] p.m., [City] time, on [●], $[●] principal amount of [TITLE OF WARRANT DEBT SECURITIES] (the
“Warrant Debt Securities”), of Personalis, Inc. (the “Company”) issued or to be issued under the Indenture (as hereinafter defined), on the following basis: during the period from [●], through
and including [●], each Warrant shall entitle the Holder thereof, subject to the provisions of this Agreement, to purchase the principal amount of Warrant Debt Securities stated in the Warrant Certificate at the warrant price (the
“Warrant Price”) of [●]% of the principal amount thereof [plus accrued amortization, if any, of the original issue discount of the Warrant Debt Securities] [plus accrued interest, if any, from the most recent date from
which interest shall have been paid on the Warrant Debt Securities or, if no interest shall have been paid on the Warrant Debt Securities, from the date of their original issuance]. [The original issue discount ($[●] for each $1,000 principal
amount of Warrant Debt Securities) will be amortized at a [●]% annual rate, computed on a[n] [semi-]annual basis [using a 360-day year consisting of twelve 30-day
months]. The Holder may exercise the Warrants evidenced hereby by providing certain information set forth on the back hereof and by paying in full, in lawful money of the United States of America, [in cash or by certified check or official bank
check in New York Clearing House funds] [by bank wire transfer in immediately available funds], the Warrant Price for each Warrant Debt Security with respect to which this Warrant is exercised to the Warrant Agent (as hereinafter defined) and by
surrendering this Warrant Certificate, with the purchase form on the back hereof duly executed, at the corporate trust office of [name of Warrant Agent], or its successor as warrant agent (the “Warrant Agent”), which is, on
the date hereof, at the address specified on the reverse hereof, and upon compliance with and subject to the conditions set forth herein and in the Warrant Agreement (as hereinafter defined). 

The term “Holder” as used herein shall mean the person in whose name at the time this Warrant Certificate shall be registered upon the
books to be maintained by the Warrant Agent for that purpose pursuant to Section 4 of the Warrant Agreement. 
 The Warrants evidenced by this Warrant
Certificate may be exercised to purchase Warrant Debt Securities in the principal amount of $1,000 or any integral multiple thereof in registered form. Upon any exercise of fewer than all of the Warrants evidenced by this Warrant Certificate, there
shall be issued to the Holder hereof a new Warrant Certificate evidencing Warrants for the aggregate principal amount of Warrant Debt Securities remaining unexercised. 

This Warrant Certificate is issued under and in accordance with the Warrant Agreement dated as of [●] (the “Warrant Agreement”),
between the Company and the Warrant Agent and is subject to the terms and provisions contained in the Warrant Agreement, to all of which terms and provisions the Holder of this Warrant Certificate consents by acceptance hereof. Copies of the Warrant
Agreement are on file at the above-mentioned office of the Warrant Agent. 

 The Warrant Debt Securities to be issued and delivered upon the exercise of Warrants evidenced by this
Warrant Certificate will be issued under and in accordance with an Indenture, dated as of [●] (the “Indenture”), between the Company and [●], as trustee (such trustee, and any successors to such trustee, the
“Trustee”)] and will be subject to the terms and provisions contained in the Warrant Debt Securities and in the Indenture. Copies of the Indenture, including the form of the Warrant Debt Securities, are on file at the
corporate trust office of the Trustee. 
 Transfer of this Warrant Certificate may be registered when this Warrant Certificate is surrendered at the
corporate trust office of the Warrant Agent by the registered owner or such owner’s assigns, in the manner and subject to the limitations provided in the Warrant Agreement. 

After countersignature by the Warrant Agent and prior to the expiration of this Warrant Certificate, this Warrant Certificate may be exchanged at the
corporate trust office of the Warrant Agent for Warrant Certificates representing Warrants for the same aggregate principal amount of Warrant Debt Securities. 

This Warrant Certificate shall not entitle the Holder hereof to any of the rights of a holder of the Warrant Debt Securities, including, without limitation,
the right to receive payments of principal of (and premium, if any) or interest, if any, on the Warrant Debt Securities or to enforce any of the covenants of the Indenture. 

Reference is hereby made to the further provisions of this Warrant Certificate set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 This Warrant Certificate shall not be valid or obligatory for any purpose until
countersigned by the Warrant Agent. 
 IN WITNESS WHEREOF, the Company has caused this Warrant to be executed in its name and on its behalf by the
facsimile signatures of its duly authorized officers. 

Dated:                         

PERSONALIS, INC., as Company 
  

			
	By:	 	  

	Name:	 	  

	Title:	 	  

		
	ATTEST:	 	  

		 	  

		
	 COUNTERSIGNED
  

[●], as Warrant Agent
	 	
		
	By:	 	  

	Name:	 	  

	Title:	 	  

		
	ATTEST:	 	  

		 	  

 [REVERSE OF WARRANT CERTIFICATE] 

(Instructions for Exercise of Warrant) 

To exercise any Warrants evidenced hereby for Warrant Debt Securities (as hereinafter defined), the Holder must pay, in lawful money of the
United States of America, [in cash or by certified check or official bank check in New York Clearing House funds] [by bank wire transfer in immediately available funds], the Warrant Price in full for Warrants exercised, to [●] [address of
Warrant Agent], Attention: [●], which payment must specify the name of the Holder and the number of Warrants exercised by such Holder. In addition, the Holder must complete the information required below and present this Warrant Certificate in
person or by mail (certified or registered mail is recommended) to the Warrant Agent at the appropriate address set forth above. This Warrant Certificate, completed and duly executed, must be received by the Warrant Agent within five business days
of the payment. 
 (To be executed upon exercise of Warrants) 

The undersigned hereby irrevocably elects to exercise              Warrants,
evidenced by this Warrant Certificate, to purchase              $[●] principal amount of the [TITLE OF WARRANT DEBT SECURITIES] (the “Warrant Debt
Securities”), of Personalis, Inc. and represents that the undersigned has tendered payment for such Warrant Debt Securities, in lawful money of the United States of America, [in cash or by certified check or official bank check in New
York Clearing House funds] [by bank wire transfer in immediately available funds], to the order of Personalis, Inc., c/o [insert name and address of Warrant Agent], in the amount of
$             in accordance with the terms hereof. The undersigned requests that said principal amount of Warrant Debt Securities be in fully registered form in the authorized
denominations, registered in such names and delivered all as specified in accordance with the instructions set forth below. 
 If the number
of Warrants exercised is less than all of the Warrants evidenced hereby, the undersigned requests that a new Warrant Certificate evidencing the Warrants for the aggregate principal amount of Warrant Debt Securities remaining unexercised be issued
and delivered to the undersigned unless otherwise specified in the instructions below. 
  

							
	Dated:	  	
                     
                                         
           
	    	Name:    	  	  

		  		    		  	Please Print

  

			
	Address:	 	
	  

     

	(Insert Social Security or Other Identifying Number of Holder)
		
	Signature Guaranteed:	 	  

		 	Signature

 (Signature must conform in all respects to name of holder as specified on the face of this Warrant Certificate and must bear a
signature guarantee by a FINRA member firm). 
 This Warrant may be exercised at the following addresses: By hand at: 

[●] 

 By mail at: 

[Instructions as to form and delivery of Warrant Debt Securities and, if applicable, Warrant Certificates evidencing Warrants for the number of Warrant Debt
Securities remaining unexercised — complete as appropriate.] 

 ASSIGNMENT 

[Form of assignment to be executed if Warrant Holder desires to transfer Warrant] 

FOR VALUE RECEIVED,              hereby sells, assigns and transfers
unto: 
  

					
	      
	 	        	  	      

	(Please print name and address including zip code)	 		  	Please print Social Security or other identifying number

 the right represented by the within Warrant to purchase
             aggregate principal amount of [Title of Warrant Debt Securities] of Personalis, Inc., to which the within Warrant relates and appoints
             attorney to transfer such right on the books of the Warrant Agent with full power of substitution in the premises. 

 

							
	Dated:    	  	                               
                             	  	                      Name:  	  	  

		  		  		  	Signature

 (Signature must conform in all respects to name of holder as specified on the face of the Warrant) 

Signature GuaranteedExhibit 10.1

 

AMENDED &
RESTATED

EMPLOYMENT
AGREEMENT

 

THIS EMPLOYMENT AGREEMENT
(the “Agreement”) is made by and between COLLEGIUM PHARMACEUTICAL, INC. (the “Company”) and
JOSEPH CIAFFONI (the “Executive”).

 

WHEREAS, the Company
and the Executive are parties to an Employment Agreement dated as of May 31, 2017, as amended (the “Existing Agreement”);
and

 

WHEREAS, the Company
and the Executive desire to amend and restate the Existing Agreement and enter into this Agreement pursuant to which the Company
will continue to employ Executive.

 

NOW, THEREFORE, in
consideration of the foregoing and intending to be bound hereby, the parties agree as follows:

 

1.           Duration
of Agreement. This Agreement is effective as of January 1, 2021 and has no specific expiration date. Unless terminated by
agreement of the parties, this Agreement will govern Executive’s continued employment by the Company until that employment
ceases.

 

2.           Title;
Duties. Executive will continue to be employed as the Company’s President and Chief Executive Officer. Executive will
devote his best efforts and substantially all of his business time and services to the Company and its affiliates to perform such
duties as may be customarily incident to his position and as may reasonably be assigned to him from time to time. Executive shall
report to the Company’s Board of Directors (the “Board”). Executive will not, in any capacity, engage
in other business activities or perform services for any other individual, firm or corporation without the prior written consent
of the Board; provided, however, that without such consent, Executive may engage in charitable, non-profit and public service
activities, so long as such activities do not in any respect interfere or conflict with Executive’s performance of his duties
and obligations to the Company; and provided further that Executive may serve on for-profit boards of directors (other than the
Board) with the consent of the Board, such consent not to be unreasonably withheld.

 

3.           Place
of Performance. Executive will perform his services hereunder at the principal executive offices of the Company in Stoughton,
Massachusetts; provided, however, that Executive may be required to travel from time to time for business purposes.

 

4.           Compensation
and Indemnification.

 

4.1          Base
Salary. Executive’s annual salary will be $657,000 (the “Base Salary”), paid in accordance with the Company’s
payroll practices as in effect from time to time. The Base Salary will be reviewed annually by the Compensation Committee of the
Company’s Board of Directors (the “Committee”).

 

     

     

    

 

4.2         Annual
Bonuses.

 

4.2.1       
 For each fiscal year ending during his employment, Executive will be eligible to earn an annual bonus. The target amount
of the annual bonus will be 70% of Executive’s Base Salary for the applicable fiscal year. The actual bonus payable with
respect to a particular year will be determined by the Committee, based on the achievement of corporate and/or individual performance
objectives established by the Committee. Any bonus payable under this paragraph will be paid during the calendar year immediately
following the fiscal year in respect of which the bonus is payable and, except as otherwise provided in Section 5.1.1 and Section
5.3.1, will only be paid if Executive remains continuously employed by the Company through the actual bonus payment date.

 

4.2.2       
For purposes of determining any bonus payable to Executive, the measurement of corporate and individual performance will
be performed by the Committee in good faith. From time to time, the Committee may, in its sole discretion, make adjustments to
corporate or individual performance goals, so that required departures from the Company’s operating budget, changes in accounting
principles, acquisitions, dispositions, mergers, consolidations and other corporate transactions, and other factors influencing
the achievement or calculation of such goals do not affect the operation of this provision in a manner inconsistent with its intended
purposes.

 

4.3         Employee
Benefits. During Executive’s employment, Executive will be eligible to participate in all employee benefit plans and
programs made available by the Company from time to time to employees generally, subject to applicable plan terms and policies.
The Company periodically reviews its benefits, policies, benefits providers and practices and may terminate, alter or change them
at its discretion from time to time.

 

4.4         Reimbursement
of Expenses. Executive will be reimbursed by the Company for all reasonable business expenses incurred by Executive in accordance
with the Company’s customary expense reimbursement policies as in effect from time to time. Notwithstanding anything herein
to the contrary, to the extent any expense, reimbursement or in-kind benefit provided to the Executive constitutes a “deferral
of compensation” within the meaning of Section 409A of the Internal Revenue Code (the “Code”) (i) the
amount of expenses eligible for reimbursement or in-kind benefits provided to the Executive must be incurred during the Executive’s
term of employment; (ii) the amount of expenses eligible for reimbursement or in-kind benefits provided to the Executive during
any calendar year will not affect the amount of expenses eligible for reimbursement or in-kind benefits provided to the Executive
in any other calendar year, (iii) the reimbursements for expenses for which the Executive is entitled to be reimbursed shall be
made on or before the last day of the calendar year following the calendar year in which the applicable expense is incurred and
(iv) the right to payment or reimbursement or in-kind benefits hereunder may not be liquidated or exchanged for any other benefit.

 

5.           Termination.
Executive’s employment with the Company may be terminated by the Company or Executive at any time and for any reason.
Upon any cessation of his employment with the Company, Executive will be entitled only to such compensation and benefits as
described in this Section 5. Upon any cessation of his employment for any reason, unless otherwise requested by the
Company, Executive agrees to resign immediately from all officer and director positions he then holds with the Company and
its affiliates.

 

    -2-

     

    

 

5.1         Termination
without Cause or for Good Reason. If Executive’s employment by the Company ceases due to a termination by the Company
without Cause (as defined below) or a resignation by Executive for Good Reason (as defined below), Executive will be entitled
to:

 

5.1.1       
payment of any annual bonus otherwise payable (but for the cessation of Executive’s employment) with respect to a
year ended prior to the cessation of Executive’s employment;

 

5.1.2       
continuation of Executive’s Base Salary for a period equal to eighteen (18) months, payable in accordance with the
Company’s standard payroll practices;

 

5.1.3       
payment equal to (i) Executive’s target annual bonus described in Section 4.2.1 multiplied by (ii) 1.5, paid in eighteen
(18) substantially equal installments over an eighteen-month period and in accordance with the Company’s standard payroll
practices;

 

5.1.4       
accelerated vesting of any unvested restricted stock, stock options and other equity incentives awarded to Executive by
the Company that are solely subject to time-based vesting criteria equal to what would have vested had Executive remained employed
for eighteen (18) additional months; and

 

5.1.5       
waiver of the applicable premium otherwise payable for COBRA continuation coverage for Executive (and, to the extent covered
immediately prior to the date of such cessation, his eligible dependents) for a period equal to eighteen (18) months.

 

Except as otherwise provided in this Section
5.1, and except for payment of all (i) accrued and unpaid Base Salary through the date of such cessation, (ii) any expense
reimbursements to be paid in accordance with Company policy and (iii) payments for any accrued but unused paid time off in accordance
with the Company’s policies and applicable law, all compensation and benefits will cease at the time of such cessation and
the Company will have no further liability or obligation by reason of such cessation. The payments and benefits described in this
Section 5.1 are in lieu of, and not in addition to, any other severance arrangement maintained by the Company. For avoidance
of doubt, any unvested restricted stock, stock options and other equity incentives awarded to Executive by the Company that are
subject to performance-based vesting shall become vested, if at all, in accordance with the Company’s Amended and Restated
2014 Stock Incentive Plan (or any successor provision or plan) (the “Plan”) and the applicable award agreement.

 

Notwithstanding any provision of this
Agreement, the payments and benefits described in Section 5.1 are conditioned on: (a) the Executive’s execution
and delivery to the Company and the expiration of all applicable statutory revocation periods, by the 45th day following the
effective date of his cessation of employment, of a general release of claims against the Company and its affiliates in a
form reasonably prescribed by the Company (the “Release”); and (b) the Executive’s continued
compliance with the Restrictive Covenants (as defined below). Subject to Section 5.5, below, the benefits described in Section
5.1 will be paid or provided (or begin to be paid or provided) as soon as administratively practicable (or determinable
in the case of the benefits described in Section 5.1.1, if later) after the Release becomes irrevocable, provided that
if the 45 day period described above begins in one taxable year and ends in a second taxable year such payments or benefits
shall not commence until the second taxable year.

 

    -3-

     

    

 

5.2         Termination
Following a Change in Control. If Executive’s employment by the Company ceases due to a termination by the Company without
Cause or a resignation by Executive for Good Reason during the twelve (12) month period immediately following the occurrence of
a Change in Control (as defined below), (i) all unvested restricted stock, stock options and other equity incentives awarded to
Executive by the Company that are subject only to time-based vesting will become immediately and automatically fully vested and
exercisable (as applicable), (ii) in lieu of the salary continuation described in Section 5.1.2, the Executive shall receive two
(2) times his Base Salary, paid in a lump sum; (iii) in lieu of the bonus described in Section 5.1.3, the Executive shall receive
two (2) times his then-current target annual bonus payable in a lump sum, and (iv) the COBRA continuation period described in
Section 5.1.5 will be twenty-four (24) months in lieu of eighteen (18) months (provided, however, that if such COBRA continuation
period expires after eighteen (18) months under applicable law, the Company will instead pay to the Executive a taxable lump sum
payment equal to six (6) months of the monthly COBRA premium then in effect. Any unvested restricted stock, stock options and
other equity incentives awarded to Executive by the Company that are subject to performance-based vesting shall become vested,
if at all, in accordance with the Plan and the applicable award agreement.

 

Any benefits received
under this Section 5.2 shall be governed by the terms and conditions described in Section 5.1 above, including without limitation
the requirement that Executive timely execute a Release and comply with the Restrictive Covenants.

 

5.3         Termination
Due to Death or Disability. If Executive’s employment by the Company ceases due to his death or Disability (as defined
below), Executive will be entitled to:

 

5.3.1       
payment of any annual bonus otherwise payable (but for the cessation of Executive’s employment) with respect to a
year ended prior to the cessation of Executive’s employment;

 

5.3.2       
an amount equal to the annual bonus that would have been paid to Executive for the fiscal year in which his employment terminates
(had his employment not terminated), multiplied by a fraction equal to the number of days Executive worked through the date of
termination of employment over 365, which amount shall be paid in the year following employment termination at the time annual
bonuses are paid to the Company’s senior executives;

 

5.3.3       
all unvested restricted stock, stock options and other equity incentives awarded to Executive by the Company shall become
fully vested; and

 

5.3.4       
waiver of the applicable premium otherwise payable for COBRA continuation coverage for Executive, if applicable (and, to
the extent covered immediately prior to the date of such cessation, his eligible dependents) for a period equal to twelve (12)
months.

 

    -4-

     

    

 

Except as otherwise provided in this Section
5.3, and except for payment of all (i) accrued and unpaid Base Salary through the date of such cessation, (ii) any
expense reimbursements to be paid in accordance with Company policy and (iii) payments for any accrued but unused paid time
off in accordance with the Company’s policies and applicable law, all compensation and benefits will cease at the time
of such cessation and the Company will have no further liability or obligation by reason of such cessation. Notwithstanding
any provision of this Agreement, the payments and benefits described in Section 5.3 are conditioned on
Executive’s (or, in the case of his death, his estate’s) satisfaction of the Release requirements set forth in Section
5.1. and the Executive’s continued compliance with the Restrictive Covenants (as defined below). Subject to Section
5.5, below, the benefits described in Section 5.3 will be paid or provided (or begin to be paid or provided) as
soon as administratively practicable (or determinable in the case of the benefits described in Section 5.3.1 and Section
5.3.2, if later) after the Release becomes irrevocable, provided that if the 45 day period described above begins in one
taxable year and ends in a second taxable year such payments or benefits shall not commence until the second taxable
year.

 

5.4         Other
Terminations. If Executive’s employment with the Company ceases for any reason other than as described in Section
5.1, Section 5.2 or Section 5.3 above (including but not limited to termination (i) by the Company for Cause
or (ii) by Executive without Good Reason, then the Company’s obligation to Executive will be limited solely to (a) accrued
and unpaid Base Salary through the date of such cessation, (b) any expense reimbursements to be paid in accordance with Company
policy and (c) payments for any accrued but unused paid time off in accordance with the Company’s policies and applicable
law. All compensation and benefits will cease at the time of such cessation and, except as otherwise provided by COBRA or this
Section 5.4, the Company will have no further liability or obligation by reason of such termination. The foregoing will
not be construed to limit Executive’s right to payment or reimbursement for claims incurred prior to the date of such termination
under any insurance contract funding an employee benefit plan, policy or arrangement of the Company in accordance with the terms
of such insurance contract.

 

5.5         Compliance
with Section 409A. If the termination giving rise to the payments described in Section 5.1, Section 5.2 or Section
5.3 is not a “Separation from Service” within the meaning of Treas. Reg. § 1.409A-1(h)(1) (or any successor
provision), then the amounts otherwise payable pursuant to that section will instead be deferred without interest and will not
be paid until Executive experiences a Separation from Service. To the maximum extent permitted under Section 409A of the Code
and its corresponding regulations, the cash severance benefits payable under this Agreement are intended to meet the requirements
of the short-term deferral exemption under Section 409A of the Code and the “separation pay exception” under Treas.
Reg. §1.409A-1(b)(9)(iii). To the extent compliance with the requirements of Treas. Reg. § 1.409A-3(i)(2) (or any successor
provision) is necessary to avoid the application of an additional tax under Section 409A of the Internal Revenue Code to payments
due to Executive upon or following his Separation from Service, then notwithstanding any other provision of this Agreement (or
any otherwise applicable plan, policy, agreement or arrangement), any such payments that are otherwise due within six months following
Executive’s Separation from Service (taking into account the preceding sentence of this paragraph) will be deferred without
interest and paid to Executive in a lump sum immediately following that six month period. For purposes of the application of Treas.
Reg. § 1.409A-1(b)(4) (or any successor provision), each payment in a series of payments will be deemed a separate payment.

 

5.6         PPACA.
Notwithstanding anything in this Agreement to the contrary, the waiver in respect of COBRA premiums pursuant to Section
5.1, Section 5.2 or Section 5.3 shall cease to the extent required to avoid adverse consequences to the
Company under the Patient Protection and Affordable Care Act of 2010 and regulations thereunder.

 

    -5-

     

    

 

5.7         Section
280G. If any payment or distribution by the Company to or for the benefit of the Executive, whether paid or payable or distributed
or distributable pursuant to the terms of this Agreement or otherwise pursuant to or by reason of any other agreement, policy,
plan, program or arrangement or the lapse or termination of any restriction on or the vesting or exercisability of any payment
or benefit (each a “Payment”), would be subject to the excise tax imposed by Section 4999 of the Code (or any
successor provision thereto) or to any similar tax imposed by state or local law (such tax or taxes are hereafter collectively
referred to as the “Excise Tax”), then the aggregate amount of Payments payable to Executive shall be reduced
to the aggregate amount of Payments that may be made to the Executive without incurring an excise tax (the “Safe-Harbor
Amount”) in accordance with the immediately following sentence; provided that such reduction shall only be imposed
if the aggregate after-tax value of the Payments retained by Executive (after giving effect to such reduction) is equal to or
greater than the aggregate after-tax value (after giving effect to the Excise Tax) of the Payments to Executive without any such
reduction. Any such reduction shall be made in the following order: (i) first, any future cash payments (if any) shall be reduced
(if necessary, to zero); (ii) second, any current cash payments shall be reduced (if necessary, to zero); (iii) third, all non-cash
payments (other than equity or equity derivative related payments) shall be reduced (if necessary, to zero); and (iv) fourth,
all equity or equity derivative payments shall be reduced.

 

5.8         Definitions.
For purposes of this Agreement:

 

5.8.1       
“Cause” means (a) commission or conviction of any felony or any crime involving dishonesty; (b) commission
of any fraud against the Company; (c) intentional and material damage to any material property of the Company; (d) Executive’s
material breach of any agreement with or duty owed to the Company or any of its affiliates (including, without limitation, Executive’s
material breach of any of the Restrictive Covenants, as defined below); or (e) refusal to perform the lawful, reasonable and material
directives of the Company’s Board of Directors (the “Board”).

 

5.8.2       
“Change in Control” means the first to occur of any of the events described in Section 1(g) of the Plan
..

 

5.8.3       
“Disability” means a condition entitling the Executive to benefits under the Company’s long term
disability plan, policy or arrangement; provided, however, that if no such plan, policy or arrangement is then maintained
by the Company and applicable to the Executive, “Disability” will mean the Executive’s inability to perform
his duties under this Agreement due to a mental or physical condition that can be expected to result in death or that can be expected
to last (or has already lasted) for a continuous period of 90 days or more, or for 120 days in any 180 consecutive day period.
Termination as a result of a Disability will not be construed as a termination by the Company “without Cause.”

 

5.8.4       
“Good Reason” means any of the following, without the Executive’s prior consent:

 

    -6-

     

    

 

(a)              
 a material diminution of the Executive’s duties or authority with the Company, reporting relationships or the assignment
of duties and responsibilities inconsistent with Executive’s status at the Company; (b) a reduction in Base Salary; or (c)
the relocation of the Executive’s primary place of employment to a location that is (i) more than 50 miles from the location
of the Executive’s permanent primary place of employment prior to such relocation and (ii) more than 50 miles from the location
of the Executive’s residence. However, none of the foregoing events or conditions will constitute Good Reason unless the
Executive provides the Company with written objection to the event or condition within 30 days following the occurrence thereof,
the Company does not reverse or otherwise cure the event or condition within 30 days of receiving that written objection, and the
Executive resigns Executive’s employment within 30 days following the expiration of that cure period. Notwithstanding the
foregoing and for the avoidance of doubt, a diminution of the Executive’s title as a result of Change in Control shall not
constitute Good Reason.

 

6.           Restrictive
Covenants. To induce the Company to enter into this Agreement and in recognition of the compensation to be paid to the Executive
pursuant to Sections 4 and 5 of this Agreement, the Executive agrees to be bound by the provisions of this Section 6
(the “Restrictive Covenants”). These Restrictive Covenants will apply without regard to whether any termination
or cessation of the Executive’s employment is initiated by the Company or the Executive, and without regard to the reason
for that termination or cessation.

 

6.1          Covenant
Not To Compete. The Executive covenants that, during his employment by the Company and for a period of eighteen (18) months
following immediately thereafter (the “Restricted Period”), the Executive will not (except in his capacity
as an employee or director of the Company) do any of the following, directly or indirectly:

 

6.1.1       
engage or participate in any Competing Business (as defined below) wherever the Company or its affiliates do business, do
or plan to do business or sell or market their products or services;

 

6.1.2       
become interested in (as owner, stockholder, lender, partner, co-venturer, director, officer, employee, agent or consultant)
any person, firm, corporation, association or other entity engaged in a Competing Business. Notwithstanding the foregoing, the
Executive may hold up to 1% of the outstanding securities of any class of any publicly-traded securities of any company;

 

6.1.3       
influence or attempt to influence any employee, consultant, supplier, licensor, licensee, contractor, agent, strategic partner,
distributor, customer or other person to terminate or modify any written or oral agreement, arrangement or course of dealing with
the Company or any of its affiliates; or

 

6.1.4        solicit
for employment or retention as an independent contractor (or arrange to have any other person or entity solicit for
employment or retention) any person employed or retained by the Company or any of its affiliates.

 

Executive acknowledges that
the consideration described in Sections 4 and 5 constitutes mutually-agreed upon consideration with respect to
the covenants set forth in Sections 6.1.1 and 6.1.2 for purposes of Section 24L(b)(vii) of Chapter 149 of the
Massachusetts General Laws.

 

    -7-

     

    

 

6.2         Confidentiality.
The Executive recognizes and acknowledges that the Proprietary Information (as defined in below) is a valuable, special and unique
asset of the business of the Company and its affiliates. As a result, both during the term of the Executive’s employment
and thereafter, the Executive will not, without the prior written consent of the Company, for any reason divulge to any third-party
or use for his own benefit, or for any purpose other than the exclusive benefit of the Company and its affiliates, any Proprietary
Information. Notwithstanding the foregoing, nothing in this Agreement prohibits Executive from initiating communications directly
with, responding to any inquiries from, providing testimony before, providing confidential information to, reporting possible
violations of law or regulation to, or from filing a claim or assisting with an investigation directly with a self-regulatory
authority or a government agency or entity, including the U.S. Equal Employment Opportunity Commission, the Department of Labor,
the National Labor Relations Board, the Department of Justice, the Securities and Exchange Commission, the Congress, and any agency
Inspector General (collectively, the “Regulators”), or from making other disclosures that are protected under
the whistleblower provisions of state or federal law or regulation. In connection with any such activity, the Executive must identify
any information that is confidential and ask the Regulator for confidential treatment of such information. Despite the foregoing,
Executive is not permitted to reveal to any third party, including any governmental, law enforcement, or regulatory authority,
information employee came to learn during the course of the Executive’s employment with the Company that is protected from
disclosure by any applicable privilege, including but not limited to the attorney-client privilege, attorney work product doctrine
and/or other applicable legal privileges. The Company and its affiliates do not waive any applicable privileges or the right to
continue to protect its privileged attorney-client information, attorney work product, and other privileged information. Notwithstanding
any other provisions of this Agreement, pursuant to 18 USC Section 1833(b), Executive shall not be held criminally or civilly
liable under any federal or state trade secret law for the disclosure of the Company’s or its affiliate’s trade secret
that is made: (a) confidentially to a federal, state, or local government official, either directly or indirectly, or to an attorney,
and solely for the purpose of reporting or investigating a suspected violation of law; or (b) in a complaint or other document
filed in a lawsuit or other proceeding, if such filing is made under seal. If Executive files a lawsuit for retaliation by the
Company for reporting a suspected violation of law, Executive may disclose a trade secret to the Executive’s attorney and
use the trade secret information in related court proceedings, provided that Executive files any document containing the trade
secret information under seal and does not disclose the trade secret, except pursuant to court order.

 

6.3         Property
of the Company.

 

6.3.1        Proprietary
Information. All right, title and interest in and to Proprietary Information will be and remain the sole and exclusive
property of the Company and its affiliates. The Executive will not remove from the Company’s or its affiliates’
offices or premises any documents, records, notebooks, files, correspondence, reports, memoranda or similar materials of or
containing Proprietary Information, or other materials or property of any kind belonging to the Company or its affiliates
unless necessary or appropriate in the performance of his duties to the Company and its affiliates. If the Executive removes
such materials or property in the performance of his duties, he will return such materials or property promptly after the
removal has served its purpose. The Executive will not make, retain, remove and/or distribute any copies of any such
materials or property, or divulge to any third person the nature of and/or contents of such materials or property, except to
the extent necessary to satisfy contractual obligations of the Company or its affiliates, to perform his duties on behalf of
the Company and its affiliates or pursuant to the exceptions set forth in Section 6.2. Upon termination of the
Executive’s employment with the Company, he will leave with the Company and its affiliates or promptly return to the
Company and its affiliates all originals and copies of such materials or property then in his possession.

 

    -8-

     

    

 

6.3.2       
Intellectual Property. The Executive agrees that all the Intellectual Property (as defined below) will be considered
 “works made for hire” as that term is defined in Section 101 of the Copyright Act (17 U.S.C. § 101) and that all
right, title and interest in such Intellectual Property will be the sole and exclusive property of the Company and its affiliates.
To the extent that any of the Intellectual Property may not by law be considered a work made for hire, or to the extent that, notwithstanding
the foregoing, the Executive retains any interest in the Intellectual Property, the Executive hereby irrevocably assigns and transfers
to the Company and its affiliates any and all right, title, or interest that the Executive may now or in the future have in the
Intellectual Property under patent, copyright, trade secret, trademark or other law, in perpetuity or for the longest period otherwise
permitted by law, without the necessity of further consideration. The Company and its affiliates will be entitled to obtain and
hold in its own name all copyrights, patents, trade secrets, trademarks and other similar registrations with respect to such Intellectual
Property. The Executive further agrees to execute any and all documents and provide any further cooperation or assistance reasonably
required by the Company, at the Company’s expense, to perfect, maintain or otherwise protect its rights in the Intellectual
Property. If the Company or its affiliates, as applicable, are unable after reasonable efforts to secure the Executive’s
signature, cooperation or assistance in accordance with the preceding sentence, whether because of the Executive’s incapacity
or any other reason whatsoever, the Executive hereby designates and appoints the Company, the appropriate affiliate, or their respective
designee as the Executive’s agent and attorney-in-fact, to act on his behalf, to execute and file documents and to do all
other lawfully permitted acts necessary or desirable to perfect, maintain or otherwise protect the Company’s or its affiliates’
rights in the Intellectual Property. The Executive acknowledges and agrees that such appointment is coupled with an interest and
is therefore irrevocable.

 

6.4         Definitions.
For purposes of this Agreement:

 

6.4.1       
“Competing Business” means any person, firm, corporation, partnership, association or other entity engaged
in developing, manufacturing, marketing, distributing or selling, directly or indirectly, pharmaceutical abuse-deterrent products
or any other product for pain indications that directly competes with a product developed, manufactured, marketed, distributed
or sold by the Company. A division, subsidiary or similar business unit of an entity that does not engage in the business activities
described in this definition will not be considered a Competing Business even if another separate division, subsidiary or similar
business unit does engage in such activities.

 

    -9-

     

    

 

6.4.2       
 “Intellectual Property” means (a) all inventions (whether patentable or unpatentable and whether or
not reduced to practice), all improvements thereto, and all patents and patent applications claiming such inventions, (b) all trademarks,
service marks, trade dress, logos, trade names, fictitious names, brand names, brand marks and corporate names, together with all
translations, adaptations, derivations, and combinations thereof and including all goodwill associated therewith, and all applications,
registrations, and renewals in connection therewith, (c) all copyrightable works, all copyrights, and all applications, registrations,
and renewals in connection therewith, (d) all mask works and all applications, registrations, and renewals in connection therewith,
(e) all trade secrets (including research and development, know-how, formulas, compositions, manufacturing and production processes
and techniques, methodologies, technical data, designs, drawings and specifications), (f) all computer software (including data,
source and object codes and related documentation), (g) all other proprietary rights, (h) all copies and tangible embodiments thereof
(in whatever form or medium), or (i) similar intangible personal property which have been or are developed or created in whole
or in part by the Executive (1) at any time and at any place while the Executive is employed by Company and which, in the case
of any or all of the foregoing, are related to and used in connection with the business of the Company or its affiliates, or (2)
as a result of tasks assigned to the Executive by the Company or its affiliates.

 

6.4.3       
“Proprietary Information” means any and all proprietary information developed or acquired by the Company
or any of its subsidiaries or affiliates that has not been specifically authorized to be disclosed. Such Proprietary Information
shall include, but shall not be limited to, the following items and information relating to the following items: (a) all intellectual
property and proprietary rights of the Company (including, without limitation, the Intellectual Property), (b) computer codes and
instructions, processing systems and techniques, inputs and outputs (regardless of the media on which stored or located) and hardware
and software configurations, designs, architecture and interfaces, (c) business research, studies, procedures and costs, (d) financial
data, (e) distribution methods, (f) marketing data, methods, plans and efforts, (g) the identities of actual and prospective suppliers,
(h) the terms of contracts and agreements with, the needs and requirements of, and the Company’s or its affiliates’
course of dealing with, actual or prospective suppliers, (i) personnel information, (j) customer and vendor credit information,
and (k) information received from third parties subject to obligations of non-disclosure or non-use. Failure by the Company or
its affiliates to mark any of the Proprietary Information as confidential or proprietary shall not affect its status as Proprietary
Information.

 

6.5         Acknowledgements.
The Executive acknowledges that the Restrictive Covenants are reasonable and necessary to protect the legitimate interests of
the Company and its affiliates, that the duration and geographic scope of the Restrictive Covenants are reasonable given the nature
of this Agreement and the position the Executive holds within the Company, and that the Company would not enter into this Agreement
or otherwise employ the Executive unless the Executive agrees to be bound by the Restrictive Covenants set forth in this Section
6.

 

    -10-

     

    

 

6.6         Remedies
and Enforcement Upon Breach.

 

6.6.1        Specific
Enforcement. The Executive acknowledges that any breach by him, willfully or otherwise, of the Restrictive Covenants will
cause continuing and irreparable injury to the Company or its affiliates for which monetary damages would not be an adequate
remedy. The Executive shall not, in any action or proceeding to enforce any of the provisions of this Agreement, assert the
claim or defense that such an adequate remedy at law exists. In the event of any such breach or threatened breach by the
Executive of any of the Restrictive Covenants, the Company or its affiliates, as applicable, shall be entitled to injunctive
or other similar equitable relief in any court, without any requirement that a bond or other security be posted, and this
Agreement shall not in any way limit remedies of law or in equity otherwise available to the Company and its affiliates.

 

6.6.2       
Judicial Modification. If any court determines that any of the Restrictive Covenants, or any part thereof, is unenforceable
because of the duration or geographical scope of such provision, such court shall have the power to modify such provision and,
in its modified form, such provision shall then be enforceable.

 

6.6.3       
Enforceability. If any court holds the Restrictive Covenants unenforceable by reason of their breadth or scope or
otherwise, it is the intention of the parties hereto that such determination not bar or in any way affect the right of the Company
and its affiliates to the relief provided above in the courts of any other jurisdiction within the geographic scope of such Restrictive
Covenants.

 

6.6.4       
Disclosure of Restrictive Covenants. The Executive agrees to disclose the existence and terms of the Restrictive
Covenants to any employer that the Executive may work for during the Restricted Period.

 

6.6.5       
Extension of Restricted Period. If the Executive breaches Section 6.1 in any respect, the restrictions contained
in that section will be extended for a period equal to the period that the Executive was in breach.

 

7.           Miscellaneous.

 

7.1         Right
to Consult Counsel. Executive understands and acknowledges that Executive has the right to consult with counsel prior to signing
this Agreement. Executive further represents that Executive is signing this Agreement freely and voluntarily in exchange for the
benefits provided herein

 

7.2         Other
Agreements. Executive represents and warrants to the Company that there are no restrictions, agreements or understandings
whatsoever to which he is a party that would prevent or make unlawful his execution of this Agreement, that would be inconsistent
or in conflict with this Agreement or Executive’s obligations hereunder, or that would otherwise prevent, limit or impair
the performance by Executive of his duties under this Agreement.

 

7.3         Successors
and Assigns. The Company may assign this Agreement to any successor to its assets and business by means of liquidation, dissolution,
sale of assets or otherwise. The duties of Executive hereunder are personal to Executive and may not be assigned by him.

 

    -11-

     

    

 

7.4         Governing
Law and Enforcement. This Agreement will be governed by and construed in accordance with the laws of the Commonwealth of
Massachusetts, without regard to the principles of conflicts of laws. Any legal proceeding arising out of or relating to this
Agreement will be instituted in a state or federal court in the Commonwealth of Massachusetts, and Executive and the Company
hereby consent to the personal and exclusive jurisdiction of such court(s) and hereby waive any objection(s) that they may
have to personal jurisdiction, the laying of venue of any such proceeding and any claim or defense of inconvenient forum.
Notwithstanding the foregoing, any action that is commenced by either party to resolve any matter arising under Section
6.1 of this Agreement, shall be commenced only in the Massachusetts Superior Court located in Suffolk County,
Massachusetts and the parties each consent to the jurisdiction of such court.

 

7.5         Waivers.
The waiver by either party of any right hereunder or of any breach by the other party will not be deemed a waiver of any other
right hereunder or of any other breach by the other party. No waiver will be deemed to have occurred unless set forth in a writing.
No waiver will constitute a continuing waiver unless specifically stated, and any waiver will operate only as to the specific
term or condition waived.

 

7.6         Severability.
Whenever possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid under applicable
law. However, if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect, such invalidity,
illegality or unenforceability will not affect any other provision, and this Agreement will be reformed, construed and enforced
as though the invalid, illegal or unenforceable provision had never been herein contained.

 

7.7         Survival.
This Agreement will survive the cessation of Executive’s employment to the extent necessary to fulfill the purposes and
intent the Agreement.

 

7.8         Notices.
Any notice or communication required or permitted under this Agreement will be made in writing and (a) sent by overnight courier,
(b) mailed by overnight U.S. express mail, return receipt requested or (c) sent by telecopier. Any notice or communication to
Executive will be sent to the address contained in his personnel file. Any notice or communication to the Company will be sent
to the Company’s principal executive offices, to the attention of its Chief Financial Officer. Notwithstanding the foregoing,
either party may change the address for notices or communications hereunder by providing written notice to the other in the manner
specified in this paragraph.

 

7.9         Entire
Agreement; Amendments. This Agreement contains the entire agreement and understanding of the parties hereto relating to the
subject matter hereof, and merges and supersedes all prior and contemporaneous discussions, agreements and understandings of every
nature relating to that subject matter (including, without limitation, the Existing Agreement). This Agreement may not be changed
or modified, except by an agreement in writing signed by each of the parties hereto.

 

    -12-

     

    

 

7.10       Withholding.
All payments (or transfers of property) to Executive will be subject to tax withholding to the extent required by applicable law.

 

7.11       Section
Headings. The headings of sections and paragraphs of this Agreement are inserted for convenience only and will not in any
way affect the meaning or construction of any provision of this Agreement.

 

7.12       Counterparts;
Facsimile. This Agreement may be executed in multiple counterparts (including by facsimile signature), each of which will
be deemed to be an original, but all of which together will constitute but one and the same instrument. Counterparts may be delivered
via facsimile, electronic mail (including pdf) or other transmission method and any counterpart so delivered shall be deemed to
have been duly and validly delivered and be valid and effective for all purposes.

 

<remainder of page intentionally left
blank; signature page follows>

 

    -13-

     

    

 

IN WITNESS
WHEREOF, the Company has caused this Agreement to be executed by its duly authorized officer, and Executive has executed this Agreement,
on the date(s) indicated below.

 

	 	COLLEGIUM PHARMACEUTICAL, INC.
	 
	 	By:	/s/ Paul Brannelly                     
	 
	 	Name:	Paul Brannelly
	 
	 	Title:	CFO
	 
	 	Date:	12/27/2020
	 
	 	JOSEPH CIAFFONI
	 
	 	/s/ Joseph Ciaffoni
	 	 
	 	Date:	12/24/2020

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