Document:

THIRD
      LEASE
      AMENDMENT AGREEMENT

    

    THIS
      THIRD LEASE AMENDMENT AGREEMENT, made as of the 1ST
      day of October, 2006
      (the
“LEASE Amendment”)
      is by
      and between ADVAXIS, INC.(“TENANT”), and the NEW JERSEY ECONOMIC DEVELOPMENT
      AUTHORITY (“LANDLORD”).

    

    WHEREAS,
      the TENANT and the LANDLORD entered into a certain Lease
      Agreement made as of June 1, 2005 (the “Lease”): and
      a
      certain Lease Amendment as of November 15, 2005: and a second Lease Amendment
      as
      of March 15, 2006. The Lease Agreement, and the Lease Amendments are
      collectively referred to as the “LEASE”.

    

    WHEREAS,
      the LANDLORD and TENANT wish to amend certain provisions contained in the
Lease
      as more
      fully set forth below.

    

    NOW,
      THEREFORE, in the joint and mutual exercise of their powers, and in
      consideration of the mutual covenants herein contained, the parties amend the
      Lease
      as
      follows:

     

    
      	1.	
              Definitions
                of LEASED PREMISES is hereby amended read as follows: 

               

              The term “LEASED PREMISES” means that portion
                of the COMMERCIALIZATION CENTER delineated on the floor plans constituting
                EXHIBIT
                1A
                attached hereto and made a part hereof, bounded by the interior sides
                of
                the centers of all demising walls other than exterior BUILDING walls
                and
                the exterior sides of all exterior BUILDING walls. For purposes of
                this
                LEASE, TENANT and LANDLORD agree that the LEASED PREMISES consists
                of Two
                (2) laboratory units made up of One Thousand Six Hundred (1,600)
                Rentable
                square feet and Two (2) office units made up of One Hundred twenty
                five
                (125) square feet each.

            

    

    
       

    

    
      	
              2.

            	
              Section
                5.2 is hereby amended to read as follows:

               

              TENANT covenants and agrees to
                pay to
                LANDLORD, RENT, in advance, on the first day of each month during
                the
                LEASE TERM for
                the lab units No. 119 and No.
                120:

            

    

     

    
      
        
        

      

      
        -1-

        
          

        

      

      
        
        

      

    

     

    
      	 	
              Period

            	
              Annualized
                Fixed Rent 

            	
                Monthly
                Fixed
                Rent

            
	 	 	 	 
	 	October 1, 2006 to 	
              $36,800.00 

            	
              $4600.00
                per month 

            
	 	 	 	 
	 	May 31, 2007 	 	
              ($2300.00
                per
                unit)

            

    

     

    During
      the LEASE TERM, TENANT shall pay to LANDLORD Rent for the office unit B113
      and
      B202/A as follows;

    
       

      
        	 	
                Period

              	
                Annualized
                  Fixed Rent 

              	
                  Monthly
                  Fixed
                  Rent

              
	 	 	 	 
	 	October 1, 2006 to 	
                $8,080.00
                  

              	
                $1,010.00
                  per month

              
	 	 	 	 
	 	May 31, 2007	 	
                 $510.00
                  per month (for
                  office B113)

                $500.00
                  per month (for
                  office B202/A)

              

      

    

      

    
      	3.	
              Section
                40.1 is hereby amended to read as
                follows:

            

    

    

    Within
      five (5) business days following TENANT’S execution of this LEASE. The
TENANT
      shall deposit with LANDLORD a security deposit in the amount of $1,000.00
      ($1,000.00 over previous security deposit) (“SECURITY DEPOSIT”) in cash funds
(paid
      by
      either certified funds, cashiers check or wire transfer). LANDLORD shall
keep
      the
      SECURITY DEPOSIT in an interest bearing account with the interest accruing
      to the benefit of the TENANT. If an EVENT OF DEFAULT by TENANT exists
      under this LEASE at any time, LANDLORD may use, apply or retain the whole
      or
      any part of the SECURITY DEPOSIT to the extent necessary to cure said
      EVENT OF DEFAULT . It is understood that the deposit is not to be considered
      as the last rental payment due under this LEASE. If at any time during
the
      term
      of this LEASE, LANDLORD applies all or a portion of this SECURITY DEPOSIT
      to cure TENANT’S EVENT OF DEFAULT, TENANT shall repay to LANDLORD within ten
      (10) business days after demand by LANDLORD any amount
      necessary to restore the SECURITY DEPOSIT to the full sum set forth above.

     

    
      
        
        

      

      
        -2-

        
          

        

      

      
        
        

      

    

     

    
      	4.	
              Miscellaneous

            

    

    

    A.
      

    Except
      as
      expressly modified hereby, all terms, conditions, definitions, undertakings
      and
      covenants of the Lease
      shall
      remain in full force and effect and are in no way abrogated by this LEASE
Amendment.
      Capitalized terms used within this LEASE Amendment
      but
      not
      otherwise defined herein shall have the meanings ascribed to them in the
Lease.

    B.

    This
      LEASE Amendment
      may be
      signed in any number of counterparts with the same effect as if the signatures
      thereto and hereto were upon the same instrument.

    C.

    If
      any
      provision of this LEASE Amendment
      shall be
      held invalid or unenforceable by any court of competent jurisdiction, such
      holding shall not invalidate or render unenforceable any other provision hereof
      or of the Lease.

    IN
      WITNESS WHEREOF, the parties hereto have duly executed this Third Lease Amendment
      as of
      the date first written above.

    

    
      	 	 	 
	ATTEST:	
              NEW
                JERSEY
                ECONOMIC DEVELOPMENT AUTHORITY,

                   
                LANDLORD

            
	 	 
 	 
 
	
              
 	By:  	 
	 	
               

              NAME:   

              TITLE:

            	
              

              Caren
                S. Franzini

              Chief
                Executive Officer

            
	 	 

    

     

    
      

      
        	 	 	 
	ATTEST:	ADVAXIS,
                INC., TENANT
	 	 
 	 
 
	
                
 	By:  	 
	 	
                 

                NAME:    

                TITLE:

              	
                

                 

              
	 	 

      

       

    

     

    
      
        
        

      

      
        -3-CONFIDENTIAL
      TREATMENT REQUEST

    [*]
      indicates information that has been omitted

    pursuant
      to a confidential treatement request and

    this
      information has been filed under separate

    cover
      with the Commission.

    

     

    SPONSORED
      RESEARCH AGREEMENT

    
 

    between

     

    ADVAXIS,
      INC.

    (SPONSOR)

    

    and

    
 

    THE
      TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

    (PENN)

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    TABLE
      OF
      CONTENTS

    
       

      
        	 	 
	
                RECITALS

              	
                1

              
	 	 
	
                ARTICLE
                  1. DEFINITIONS

              	
                1

              
	 	 
	
                ARTICLE
                  2. SPONSORED RESEARCH

              	
                2

              
	 	 
	
                ARTICLE
                  3. TERM OF AGREEMENT

              	
                2

              
	 	 
	
                ARTICLE
                  4. REIMBURSEMENT OF COSTS, PAYMENT

              	
                2

              
	 	 
	
                ARTICLE
                  5. RECORDS AND REPORTS

              	
                2

              
	 	 
	
                ARTICLE
                  6. SPONSOR’S
                  RIGHTS IN RESEARCH RESULTS AND REPORTS

              	
                3

              
	 	 
	
                ARTICLE
                  7. INTELLECTUAL PROPERTY

              	
                3

              
	 	 
	
                ARTICLE
                  8. CONFIDENTIALITY, PUBLICATION, USE OF NAME

              	
                4

              
	 	 
	
                ARTICLE
                  9. TERMINATION

              	
                4

              
	 	 
	
                ARTICLE
                  10. DISCLAIMER OF WARRANTIES, INDEMNIFICATION

              	
                7

              
	 	 
	
                ARTICLE
                  11. ADDITIONAL PROVISIONS

              	
                7

              
	 	 
	
                Attachment
                  A

              	
                8

              
	 	 
	
                Appendix
                  1

              	
                9

              
	 	 
	
                Attachment
                  B

              	
                11

              
	 	 
	
                Attachment
                  C

              	
                13

              

      
 

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

       

    

    SPONSORED
      RESEARCH AGREEMENT

     

    This
      Sponsored Research Agreement ("AGREEMENT") is made by and between The Trustees
      of the University of Pennsylvania, a Pennsylvania nonprofit corporation
      ("PENN"), with offices located at Franklin Building, Room P221, 3451 Walnut
      Street, Philadelphia, PA 19104-6205, and Advaxis, Inc., a corporation organized
      and existing under the laws of Delaware ("SPONSOR"), having a place of business
      at 675 Route 1, Ste 113B, N. Brunswick, NJ 08902.

    

    This
      AGREEMENT is effective as of the first day of November, 2006 ("EFFECTIVE
      DATE").

    

    RECITALS

    

    PENN
      and
      SPONSOR are entering into this AGREEMENT since SPONSOR desires to fund the
      research of Dr. Yvonne Paterson of PENN's School of Medicine in certain specific
      areas. SPONSOR desires to support such research conducted by PENN in accordance
      with the terms and conditions of this AGREEMENT. The research program
      contemplated by this AGREEMENT is of mutual interest to SPONSOR and PENN and
      furthers the educational, scholarship and research objectives of PENN as a
      nonprofit, tax-exempt, educational institution, and may benefit both SPONSOR
      and
      PENN through the creation or discovery of new inventions.

    

    In
      consideration of the promises and mutual covenants contained herein, and
      intending to be legally bound hereby, the parties hereto agree as
      follows:

    

    ARTICLE
      1.
      DEFINITIONS

     

    1.1
      PENN
      INTELLECTUAL PROPERTY means all patentable inventions conceived and reduced
      to practice in the conduct of the SPONSORED RESEARCH during the term of this
      Agreement, including all United States and foreign patent applications claiming
      said patentable inventions, including any divisional, continuation,
      continuation-in-part (to the extent that the claims are directed to said
      patentable inventions), and foreign equivalents thereof, as well as any patents
      issued thereon or reissues or reexaminations thereof. PENN INTELLECTUAL PROPERTY
      also includes all significant copyrightable software created in the conduct
      of
      the SPONSORED RESEARCH during the term of this AGREEMENT. PENN INTELLECTUAL
      PROPERTY shall not include any patent application or patent issues,
      continuation, continuation in part or any other intellectual property licensed
      to SPONSOR by PENN under a license agreement having an Effective Date of July
      1,
      2002 as amended (“LICENSE”, see Attachment C).

    

    1.2
      PRINCIPAL INVESTIGATOR means Dr. Yvonne Paterson who has agreed to serve as
      faculty investigator for the SPONSORED RESEARCH and shall be responsible for
      the
      conduct, supervision and administration of the SPONSORED RESEARCH.

    

    1.3
      RESEARCH RESULTS means all data and information which are generated in the
      performance of the SPONSORED RESEARCH during the term of this AGREEMENT.
      RESEARCH RESULTS expressly excludes PENN INTELLECTUAL PROPERTY.

    

    1.4
      SPONSORED RESEARCH means the research program described in Attachment A to
      this
      AGREEMENT.

    

    ARTICLE
      2.
      SPONSORED RESEARCH 

    

    2.1
      PENN
      shall commence the SPONSORED RESEARCH after the EFFECTIVE DATE of this AGREEMENT
      and upon payment by SPONSOR of any funds owed, and shall use good faith efforts
      to conduct such SPONSORED RESEARCH substantially in accordance with the terms
      and conditions of this AGREEMENT. SPONSOR acknowledges that PENN and the
      PRINCIPAL INVESTIGATOR shall have the freedom to conduct and supervise the
      SPONSORED RESEARCH in a manner consistent with PENN's educational and research
      missions.

    

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

       

    

    2.2 
      If the
      services of the PRINCIPAL INVESTIGATOR become unavailable to PENN for any
      reason, PENN shall be entitled to designate another member of its faculty who
      is
      acceptable to SPONSOR to serve as the PRINCIPAL INVESTIGATOR of the SPONSORED
      RESEARCH. If a substitute PRINCIPAL INVESTIGATOR has not been designated within
      sixty (60) days after the original PRINCIPAL INVESTIGATOR ceases his or her
      services under this AGREEMENT, either party may terminate this AGREEMENT upon
      written notice thereof to the other party, subject to the provisions of ARTICLE
      9.

    

    ARTICLE
      3.
      TERM OF
      AGREEMENT

    

    3.1
      The
      initial term of this AGREEMENT shall begin on the EFFECTIVE DATE of this
      AGREEMENT and shall end two years later unless terminated sooner pursuant to
      Sections 2.2 or 9.2 hereof. This AGREEMENT may be extended or renewed only
      by
      mutual written agreement executed by duly authorized representatives of the
      parties.

    

    ARTICLE
      4.
      REIMBURSEMENT OF COSTS, PAYMENT

    

    4.1
      SPONSOR
      shall reimburse PENN for all direct and indirect costs incurred in the conduct
      of the SPONSORED RESEARCH in an amount not to exceed the total amount of
      $ 118,755
      as set forth in Attachment A. SPONSOR acknowledges that this amount is a good
      faith estimate only and not a guarantee of the cost to conduct the SPONSORED
      RESEARCH. If at any time PENN determines that it will require additional funds
      for the SPONSORED RESEARCH, it shall notify SPONSOR and provide an estimate
      of
      the additional amount. SPONSOR shall not be liable for any costs in excess
      of
      the amount of $118,755 unless it has agreed in writing to provide additional
      funds.

    

    4.2
      SPONSOR
      shall make payments in advance to PENN in accordance with the payment schedule
      set forth in Attachment A. All payments shall clearly identify the PRINCIPAL
      INVESTIGATOR and SPONSORED RESEARCH. All payments are to be made by check
      payable in United States dollars, to "The Trustees of the University of
      Pennsylvania", and sent to:

     

    The
      University of Pennsylvania

    Office
      of
      Research Services

    P.O.
      Box
      7777-W9535

    Philadelphia,
      PA 19175

    

    4.3
      Title to
      any equipment, laboratory animals, or any other materials made or acquired
      with
      funds provided under this AGREEMENT shall vest in PENN, and such equipment,
      animals, or materials shall remain the property of PENN following termination
      of
      this AGREEMENT. 

    

    ARTICLE
      5.
      RECORDS
      AND REPORTS 

    

    5.1
      PRINCIPAL INVESTIGATOR shall maintain records of the results of the SPONSORED
      RESEARCH and shall provide SPONSOR with reports of the progress and results
      of
      the SPONSORED RESEARCH in accordance with Attachment A. PENN shall maintain
      records of the use of the funds provided by SPONSOR and shall make such records
      available to SPONSOR upon reasonable notice during PENN's normal business hours,
      but not more frequently than each anniversary of the EFFECTIVE
      DATE.

    

    ARTICLE
      6.
      SPONSOR’S RIGHTS IN RESEARCH RESULTS AND REPORTS

    

    6.1
      SPONSOR shall have the right to use RESEARCH RESULTS disclosed to SPONSOR in
      records and reports for any reasonable purpose. SPONSOR shall need to obtain
      a
      license to use RESEARCH RESULTS from PENN if such use would infringe any
      copyright or any claim of a patent application or issued patent owned by PENN.
      

    

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

       

    

    6.2
      PENN
      and the PRINCIPAL INVESTIGATOR hereby grant SPONSOR a royalty-free,
      nontransferable, non-exclusive right to copy, reproduce and distribute any
      research reports furnished to SPONSOR under this AGREEMENT. SPONSOR may not
      charge fees for said research reports, use said research reports for advertising
      or promotional activities, or alter or modify said research reports without
      the
      prior written permission of PENN. 

    

    ARTICLE
      7.
      INTELLECTUAL PROPERTY 

     

    7.1
      PENN
      shall retain all right, title and interest in and to the PENN INTELLECTUAL
      PROPERTY and any patents, copyrights, software and tangible research materials
      and other intellectual property related thereto.

    

    7.2
      PRINCIPAL INVESTIGATOR shall provide PENN and SPONSOR a written disclosure
      of
      any PENN INTELLECTUAL PROPERTY reasonably considered patentable. SPONSOR shall
      advise PENN in writing, no later than sixty (60) days after receipt of such
      disclosure, whether it requests PENN to file and prosecute patent applications
      related to such PENN INTELLECTUAL PROPERTY. If SPONSOR does not request PENN
      to
      file and prosecute such patent applications, PENN may proceed with such
      preparation and prosecution at its own cost and expense; but such patent
      applications shall be excluded from SPONSOR's option under Section 7.5
      hereof.

    

    7.3
      PENN
      shall control the preparation and prosecution of all patent applications and
      the
      maintenance of all patents related to PENN INTELLECTUAL PROPERTY. With regard
      to
      any patent applications filed at the request and expense of SPONSOR, PENN will
      consult with SPONSOR on patent prosecution. SPONSOR shall reimburse PENN upon
      receipt of invoice for all documented expenses incurred in connection with
      the
      filing and prosecution of the patent applications and maintenance of the patents
      that SPONSOR has requested PENN to prosecute under Section 7.2
      hereof.

    

    7.4
      PRINCIPAL INVESTIGATOR shall provide PENN and SPONSOR a written disclosure
      of
      any copyrightable software created in the conduct of the SPONSORED RESEARCH
      during the term of this Agreement that PRINCIPAL INVESTIGATOR reasonably
      considers to be scientifically valuable.

     

    7.5
      In
      consideration of SPONSOR's funding of the SPONSORED RESEARCH and

    payment
      for intellectual property expenses as provided for in Section 7.3, PENN grants
      SPONSOR a first option to negotiate to acquire a license on terms substantially
      similar to the terms of LICENSE and in accordance with industry standards to
      practice PENN INTELLECTUAL PROPERTY. PENN and SPONSOR will negotiate in good
      faith to determine the terms of a license agreement as to each item of PENN
      INTELLECTUAL PROPERTY for which SPONSOR has agreed to make payment for
      intellectual property expenses as provided for in Section 7.3, if any. For
      PENN
      INTELLECTUAL PROPERTY subject to the conditions in Section 2.6 of LICENSE all
      terms specified in Section 2.6 of LICENSE shall apply. If SPONSOR and PENN
      fail
      to execute a license agreement within six (6) months after disclosure of the
      PENN INTELLECTUAL PROPERTY to SPONSOR or if SPONSOR fails to make payment for
      intellectual property expenses as provided for in Section 7.3, PENN shall be
      free to license the PENN INTELLECTUAL PROPERTY to any party upon such terms
      as
      PENN deems appropriate, without any further obligation to SPONSOR. 

    

    7.6
      Any
      license granted to SPONSOR pursuant to Section 7.5 hereof shall be subject
      to
      PENN’s right to use and permit other non-profit organizations to use PENN
      INTELLECTUAL PROPERTY for educational and research purposes and, if applicable,
      to the rights of the United States government reserved under Public Laws 96-517,
      97-256 and 98-620, codified at 35 U.S.C. 200-212, and any regulations issued
      thereunder.

    

    ARTICLE
      8.
      CONFIDENTIALITY, PUBLICATION, USE OF NAME

    

    8.1
      PENN
      shall not be obligated to accept any confidential information from SPONSOR.
      

    If
      SPONSOR desires to furnish any confidential information to the PRINCIPAL
      INVESTIGATOR, SPONSOR may request the PRINCIPAL INVESTIGATOR to sign the
“Agreement between SPONSOR and PRINCIPAL INVESTIGATOR concerning SPONSOR’s
      Confidential Information” that is attached as Attachment B. PENN bears no
      responsibility for maintaining the confidentiality of any confidential
      information of SPONSOR provided under such an individual agreement.

    

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

       

    

    8.2
      In
      order to preserve the patentability of PENN INTELLECTUAL PROPERTY, SPONSOR
      shall
      maintain PENN INTELLECTUAL PROPERTY and information provided pursuant to the
      SPONSORED RESEARCH (whether oral or written) as confidential and shall not
      disclose such information to any third party until the publication of such
      information by the PRINCIPAL INVESTIGATOR or until PENN provides SPONSOR with
      written verification that all desirable patentable inventions have been
      protected, whichever occurs sooner.

    

    8.3
      PENN
      shall be free to publish, present or otherwise disclose RESEARCH RESULTS or
      other information and material resulting from the SPONSORED RESEARCH for any
      purpose. PENN shall furnish the SPONSOR with a copy of any proposed publication
      or presentation at least thirty (30) days in advance of the submission of said
      proposed publication in order for SPONSOR to review and comment on said proposed
      publication.

    

    8.4
      PENN
      shall not use SPONSOR's name without SPONSOR's prior written consent except
      that
      PENN may acknowledge SPONSOR's funding of this SPONSORED RESEARCH and any
      scientific contributions in scientific publications and in listings of sponsored
      research projects. SPONSOR shall not use PENN's name, or the name of any
      trustee, officer, faculty member, student or employee thereof, without PENN's
      prior written consent.

    

    ARTICLE
      9.
      TERMINATION

    

    9.1
      In
      addition to the termination right set forth in Section 2.2 hereof, either party
      may terminate this AGREEMENT effective upon written notice to the other party,
      if the other party breaches any of the terms or conditions of this AGREEMENT
      and
      fails to cure such breach within thirty (30) days after receiving written notice
      thereof. In the event of an incurable breach, the non-breaching party may
      terminate this AGREEMENT effective immediately upon written notice to the
      breaching party. 

    

    9.2
      In the
      event of termination of this AGREEMENT prior to its stated term whether for
      breach or for any other reason whatsoever, PENN shall be entitled to retain
      from
      the payments made by SPONSOR prior to termination PENN's reasonable costs of
      concluding the work in progress. Allowable costs include, without limitation,
      all costs or noncancellable commitments incurred prior to the receipt, or
      issuance, by PENN of the notice of termination, and the full cost of each
      employee, student and faculty member supported hereunder through the end of
      such
      commitments. In the event of termination, PENN shall submit a final report
      of
      all costs incurred and all funds received under this AGREEMENT within ninety
      (90) days after the effective termination date. The report shall be accompanied
      by a check in the amount of any excess of funds advanced over costs and
      allowable commitments incurred. In case of a deficit of funds, SPONSOR shall
      pay
      PENN the amount needed to cover costs and allowable commitments incurred by
      PENN
      under this AGREEMENT.

    

    9.3
      Termination of this AGREEMENT shall not affect the rights and obligations of
      the
      parties accrued prior to termination hereof. The provisions of ARTICLE 4,
      entitled REIMBURSEMENT OF COSTS, PAYMENT; ARTICLE 6, entitled SPONSOR’S RIGHTS
      IN RESEARCH RESULTS AND REPORTS; ARTICLE 7, entitled INTELLECTUAL PROPERTY;
      ARTICLE 8 entitled CONFIDENTIALITY, PUBLICATION, USE OF NAME , ARTICLE 10,
      entitled DISCLAIMER OF WARRANTIES, INDEMNIFICATION; and ARTICLE 11, entitled
      ADDITIONAL PROVISIONS, shall survive such termination. 

     

    ARTICLE
      10.
      DISCLAIMER OF WARRANTIES, INDEMNIFICATION

    

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

       

    

    10.1 PENN
      MAKES NO WARRANTIES, EXPRESS OR IMPLIED, AS TO ANY MATTER WHATSOEVER, INCLUDING,
      WITHOUT LIMITATION, WARRANTIES WITH RESPECT TO THE CONDUCT, COMPLETION, SUCCESS
      OR PARTICULAR RESULTS OF THE SPONSORED RESEARCH, OR THE CONDITION, OWNERSHIP,
      MERCHANTABILITY, OR FITNESS FOR A PARTICULAR PURPOSE OF THE SPONSORED RESEARCH
      OR ANY PENN INTELLECTUAL PROPERTY OR RESEARCH RESULTS OR THAT USE OF THE PENN
      INTELLECTUAL PROPERTY OR RESEARCH RESULTS WILL NOT INFRINGE ANY PATENT,
      COPYRIGHT, TRADEMARK OR OTHER INTELLECTUAL PROPERTY RIGHT OF A THIRD PARTY.
      PENN
      SHALL NOT BE LIABLE FOR ANY DIRECT, INDIRECT, CONSEQUENTIAL, PUNITIVE OR OTHER
      DAMAGES SUFFERED BY SPONSOR OR ANY OTHER PERSON RESULTING FROM THE SPONSORED
      RESEARCH OR THE USE OF ANY PENN INTELLECTUAL PROPERTY, ANY RESEARCH RESULTS
      OR
      ANY PRODUCTS RESULTING THEREFROM.

    

    10.2
      SPONSOR
      shall defend, indemnify and hold harmless PENN, the PRINCIPAL INVESTIGATOR
      and
      any of PENN's faculty, students, employees, trustees, officers, affiliates
      and
      agents (hereinafter referred to collectively as the "INDEMNIFIED PERSONS")
      from
      and against any and all liability, claims, lawsuits, losses, damages, costs
      or
      expenses (including attorneys' fees), which the INDEMNIFIED PERSONS may
      hereafter incur, or be required to pay as a result of SPONSOR's use of the
      results of SPONSORED RESEARCH or any PENN INTELLECTUAL PROPERTY or RESEARCH
      RESULTS or as a result of any breach of this AGREEMENT or any act or omission
      of
      SPONSOR, its employees, affiliates, contractors, licensees or agents. PENN
      shall
      notify SPONSOR upon learning of the institution or threatened institution of
      any
      such liability, claims, lawsuits, losses, damages, costs and expenses and PENN
      shall cooperate with SPONSOR in every proper way in the defense or settlement
      thereof at SPONSOR's request and expense. 

     

    ARTICLE
      11.
      ADDITIONAL PROVISIONS

    

    11.1
      No
      rights hereunder may be assigned by SPONSOR, directly or by merger or other
      operation of law, without the express written consent of PENN, which consent
      shall not be unreasonably withheld. Any prohibited assignment of this AGREEMENT
      or the rights hereunder shall be null and void. No assignment shall relieve
      SPONSOR of responsibility for the performance of any accrued obligations, which
      it has prior to such assignment.

    

    11.2
      A waiver
      by either party of a breach or violation of any provision of this AGREEMENT
      will
      not constitute or be construed as a waiver of any subsequent breach or violation
      of that provision or as a waiver of any breach or violation of any other
      provision of this AGREEMENT.

    

    11.3
      Nothing
      herein shall be deemed to establish a relationship of principal and agent
      between PENN and SPONSOR, nor any of their agents or employees, nor shall this
      AGREEMENT be construed as creating any form of legal association or arrangement
      which would impose liability upon one party for the act or failure to act of
      the
      other party. Nothing in this AGREEMENT, express or implied, is intended to
      confer on any person other than the parties hereto or their permitted assigns,
      any benefits, rights or remedies.

    

    11.4
      Notices,
      statements, reports and other communications under this AGREEMENT shall be
      in
      writing and shall be deemed to have been received as of the date dispatched
      if
      sent by public overnight courier (e.g., Federal Express) and addressed as
      follows:

     

    If
      to
      PENN:

    

    Research
      Services

    University
      of Pennsylvania

    Franklin
      Building, Room P221

    3451
      Walnut Street

    Philadelphia,
      PA 19104-6205

    Attn.:
      Executive Director

    

    
      
        
        

      

      
        7
          of 14

        
          

        

      

      
        
        

      

       

    

    If
      to
      PRINCIPAL INVESTIGATOR:

    

    Yvonne
      Paterson, Ph.D.

    Department
      of Microbiology

    University
      of Pennsylvania

    323A
      Johnson Pavilion

    Philadelphia,
      PA 19104

    

    If
      to
      SPONSOR:

    

    Att:
      Roni
      Appel, CEO

    Advaxis,
      Inc

    675
      Route
      1

    N.
      Brunswick, NJ 08902

     

    11.5
      This
      AGREEMENT shall be construed and governed in accordance with the laws of the
      Commonwealth of Pennsylvania, without giving effect to conflict of law
      provisions. The parties hereby submit to the exclusive jurisdiction of and
      venue
      in any state or federal courts located within the Eastern District of
      Pennsylvania with respect to any and all disputes concerning the subject of
      this
      AGREEMENT.

    

    11.6
      PENN and
      SPONSOR shall not discriminate against any employee or applicant for employment
      because of race, color, sex, sexual or affectional preference, age, religion,
      national or ethnic origin, handicap, or because he or she is a disabled veteran
      or veteran of the Vietnam Era. 

    

    11.7
      Neither
      party shall be liable for any failure to perform as required by this AGREEMENT
      to the extent such failure to perform is due to circumstances reasonably beyond
      such party's control, including, without limitation, labor disturbances or
      labor
      disputes of any kind, accidents, failure of any governmental approval required
      for full performance, civil disorders or commotions, acts of aggression, acts
      of
      God, energy or other conservation measures imposed by law or regulation,
      explosions, failure of utilities, mechanical breakdowns, material shortages,
      disease, or other such occurrences.

    

    11.8
      SPONSOR
      shall comply with all laws, regulations and other legal requirements applicable
      to SPONSOR in connection with this AGREEMENT, including but not limited to
      any
      legal requirements applicable to SPONSOR's use of the results of the SPONSORED
      RESEARCH or any PENN INTELLECTUAL PROPERTY or RESEARCH RESULTS and laws
      controlling the export of technical data, computer software, laboratory
      prototypes, and all other export controlled commodities.

    

    11.9
      This
      AGREEMENT embodies the entire understanding between the parties relating to
      the
      subject matter hereof and supersedes all prior understandings and agreements,
      whether written or oral. This AGREEMENT may not be varied except by a written
      document signed by duly authorized representatives of both parties.

     

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

    

    IN
      WITNESS WHEREOF, the duly authorized representatives of the parties hereby
      execute this AGREEMENT as of the date first written above.

    

    
      	
              THE
                TRUSTEES OF THE 

            	
              ADVAXIS,
                INC.

            
	
              UNIVERSITY
                OF PENNSYLVANIA

            	 	 
	 	 	 	 
	 	 	 	 
	
              By:

            	 	
              By:

            	 
	 	
              
 	 	
              
 
	
              Name:

            	 	
              Name:

            	 
	 	
              
 	 	
              
 
	
              Title:

            	 	
              Title:

            	 
	 	
              
 	 	
              
 
	
              Date:

            	 	
              Date:

            	 
	 	
              
 	 	
              
 

    

    

    

    I
      have
      read and agreed to the responsibilities of the PRINCIPAL
      INVESTIGATOR:

    

    

    
      	
              By:

            	
               

            	Date:	
               

            
	 	
              
                
Yvonne
                Paterson, Ph. D.

            	 	
              
 

    

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

    

    Attachment
      A

    Summary
      of SPONSORED RESEARCH

     

    1)
      Work
      Scope

    

    2)
      Details of Program - See Appendix 1

     

    PRINCIPAL
      INVESTIGATOR:

     

    
      1) Name:
        Yvonne Paterson, Ph.D.

    

    
      2) Phone
        Number: 215-898-3461

    

     

    Representative
      of SPONSOR:

    

    1)
      Name:
      Roni Appel

    2)
      Phone
      Number: 732 545 1590

     

    Period
      of
      Performance: Two years

    

    

    Report
      Schedule: 

    

    Final
      report within thirty (30) days after termination

    

    

    Budget:

    

    Total
      Direct Costs = $100,693, per annum

    Indirect
      Costs = $58,905

    

    Total
      Costs per annum = $159,598 

    Total
      costs for period of award =$319,196

    

    Payment
      Schedule:

    

    Payments
      will be made every quarter such that an initial payment of 25% of the total
      costs per annum will be due and payable upon signing this AGREEMENT, 25% will
      become due three (3) months after signing of this AGREEMENT, and for every
      three
      months thereafter for the term of the agreement. The last payment is thus due
      August 1, 2008.

    

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

    

    Appendix
      1

    

    Appendix
      1

    

    [*]

    

    
      
        
        

      

      
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          of 14

        
          

        

      

      
        
        

      

    

    [*] 

    

    
      
        
        

      

      
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    Attachment
      B

    

    SPONSOR
      CONFIDENTIAL INFORMATION

    

    The
      free
      publication and dissemination of research results and information is an
      essential and long-standing policy of the University of Pennsylvania. Because
      of
      the negative impact confidentiality obligations can have on the educational
      mission of the University and the free communication of research results, the
      University does not undertake to keep proprietary information provided by a
      commercial sponsor confidential. Under certain circumstances, however, the
      University recognizes that a University principal investigator (the
“Investigator”) under a commercially sponsored research program may desire to
      receive confidential and proprietary information of the commercial sponsor
      (“Sponsor”) that the Investigator considers essential for the conduct of the
      research program. Accordingly, the University will permit the Investigator
      to
      accept confidential information of a Sponsor under the terms and conditions
      of
      the agreement between the Sponsor and Investigator stated below.

     

    Agreement
      between Sponsor and Principal Investigator 

    Concerning
      Sponsor Confidential Information

    

    In
      connection with research to be conducted at the University of Pennsylvania
      (“University”) sponsored by [Insert name of research sponsor] (“Sponsor”) and
      relating to [Insert brief description of the research ] (the “Sponsored
      Research”), Sponsor desires to provide [Insert name of Principal Investigator]
      (“Investigator”) with certain information that Sponsor considers confidential.

    

    
      	
              1.

            	
              For
                purposes of this Agreement, “Confidential Information” means only
                confidential information of Sponsor related to the Sponsored Research
                that
                is disclosed to the Investigator by Sponsor in writing and conspicuously
                marked as confidential and proprietary at the time of disclosure,
                or, if
                disclosed visually or orally, is stated to be confidential and proprietary
                at the time of disclosure and confirmed by a written summary describing
                the information in reasonable detail delivered by Sponsor to Investigator
                within seven (7) days after disclosure. Notwithstanding anything to the
                contrary contained in this Agreement or the markings on any document
                disclosed by Sponsor, Confidential Information does
                not include: 

            

    

    

    
      	 	
              (a)

            	
              information
                that is reasonably required by scientific standards for publication
                of the
                Sponsored Research, or any information that is necessary for other
                scholars to verify the results of the Sponsored
                Research;

            

    

    

    
      	 	
              (b)

            	
              information
                that is in the public domain at the time Sponsor discloses it to
                Investigator or that thereafter enters the public domain through
                no fault
                of Investigator;

            

    

    

    
      	 	
              (c)

            	
              information
                that was known to Investigator or to the University before the date
                Sponsor discloses it to Investigator, or that becomes known to
                Investigator or the University through a third party having an apparent
                bona fide right to disclose the
                information;

            

    

    

    
      	 	
              (d)

            	
              information
                that is independently developed by University
                personnel;

            

    

    

    
      	 	
              (e)

            	
              information
                that is disclosed by Investigator or the University in accordance
                with the
                terms of Sponsor’s written
                approval;

            

    

    

    
      	 	
              (f)

            	
              information
                that is required to be disclosed for compliance with any Federal,
                state or
                local law or regulation, or required to be disclosed by a court of
                law or
                governmental authority.

            

    

    

    2. The
      Investigator retains the right to refuse to accept any Confidential Information
      that the Investigator does not consider to be essential to the performance
      of
      the Sponsored Research or that the Investigator believes to be improperly
      designated as Confidential Information.

    

    
      
        
        

      

      
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    3. In
      the
      event the Investigator does accept any Confidential Information, for a period
      of
      three (3) years after Investigator’s acceptance of Confidential Information,
      Investigator agrees to use efforts no less than those Investigator employs
      with
      respect to Investigator’s own confidential information:

    

    
      	 	
              (a)

            	
              not
                to disclose the Confidential Information to third parties without
                Sponsor’s consent to such disclosure;
                and

            

    

    
      	 	 	 

    

    
      	 	
              (b)

            	
              to
                use the Confidential Information only in furtherance of the Sponsored
                Research.

            

    

    

    4. Sponsor
      specifically acknowledges its understanding that the Investigator's efforts
      hereunder will not necessarily conform to prevailing commercial standards for
      the protection of confidential and proprietary information. Sponsor expressly
      agrees that the University shall not be liable for any disclosure of Sponsor’s
      Confidential Information.

    

    5. This
      Agreement sets forth the entire understanding of Sponsor and Investigator with
      respect to the subject matter hereof, supersedes any prior agreement between
      Sponsor and Investigator, and there are no other understandings or agreements,
      written or oral, between them relating to such subject matter. The Agreement
      may
      not be changed or supplemented in any way except by a written agreement duly
      executed by both Sponsor and Investigator and approved by the University. This
      Agreement shall be governed by, enforced, and interpreted in accordance with
      the
      laws of the Commonwealth of Pennsylvania, without giving effect to its
      principles of conflict of laws.

    
      

      
        	SPONSOR	INVESTIGATOR
	 	 	 	 
	 	 	 	 
	 	
                
 	 	
                
 
	
                Date:

              	 	
                Date:

              	 
	 	
                
 	 	
                
 

      

     

    
      
        
        

      

      
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