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                                November 1, 2001

Protection One, Inc.
Protection One Alarm Monitoring, Inc.
818 S. Kansas Avenue
Topeka, Kansas 66612

         Attention:        Richard Ginsburg
                           President and Chief Executive Officer

Ladies and Gentlemen:

         This letter agreement confirms the terms on which Westar Industries,
Inc. ("Westar") has agreed to provide Protection One, Inc. and Protection One
alarm Monitoring, Inc. (collectively, "Protection One") management and financial
advisory services.

         During the period of Westar's engagement under this letter (as
specified below), Westar will, if requested:

         (a)      review and analyze, in consultation with members of
management, the business, operations and financial condition of Protection One;

         (b)      review and analyze, in consultation with members of
management, Protection One's financial and strategic plans and business
alternatives;

         (c)      review and evaluate, in consultation with members of
management, Protection One's capital structure and potential financing and
refinancing alternatives;

         (d)      review and evaluate, in consultation with members of
management, strategies to reduce the amount of Protection One's outstanding
debt; and

         (e)      render such other similar or related financial and advising
services as may be requested from time to time by Protection One.

         During the period of Westar's engagement, Westar will continue to seek
and obtain information regarding developments affecting Protection One in an
effort to stay current with respect to Protection One's business, operations,
financial condition and prospects. In addition, Westar will be available at
Protection One's request to meet with members of Protection One's management to
discuss strategic and financial alternatives and their financial implications.

         As compensation for Westar's services hereunder, Protection One agrees
to pay Westar, in arrears within fifteen days following the end of each calendar
quarter beginning with the quarter ending March 31, 2002, an annual management
and financial advisory fee equal to .50 percent of Protection One's consolidated
total assets on the last day of the quarter.

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         Payment of the fees contemplated hereby shall entitle Protection One to
use of Westar's Cessna Citation VII plane, or another aircraft designated by
Westar if such plane is no longer owned by Westar or is otherwise unavailable,
for 140 hours of flight time in each twelve-month period after the date of this
Agreement, subject to the payment of operating costs for the plane for the
flight time actually used. Protection One may purchase additional hours of use,
subject to availability, at the same hourly rate Westar allocates internally for
use of the plane.

         The engagement of Westar under this letter agreement, and the payment
of the fees contemplated hereby, will continue so long as Westar owns at least a
majority of Protection One's outstanding capital stock.

         In connection with this engagement, Westar is acting as an independent
contractor and not in any other capacity, with duties owing solely to Protection
One. All aspects of the relationship created by this agreement shall be governed
by and construed in accordance with the laws of the State of Delaware,
applicable to contracts made and to be performed therein.

         Please confirm that the foregoing is in accordance with Protection
One's understanding by signing and returning to Westar the enclosed duplicate of
this letter.

                                            Very truly yours,

                                            WESTAR INDUSTRIES, INC.

                                            By: /s/ Paul R. Geist
                                                -----------------
                                                     Paul R. Geist
                                                     President

Accepted and agreed to as of the date first written above:

PROTECTION ONE, INC.

By: /s/ Richard Ginsburg
    --------------------
         Richard Ginsburg
         President and Chief Executive Officer

PROTECTION ONE ALARM MONITORING, INC.

By: /s/ Richard Ginsburg
    --------------------
         Richard Ginsburg
         President and Chief Executive OfficerQuickLinks
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Exhibit 10.18    
  

 
 

FIFTH AMENDMENT    
  

THIS
FIFTH AMENDMENT ("Agreement") is made and entered into as of December 5, 2001, by and among KASHIWA FUDOSAN AMERICA, INC., a
California corporation ("Landlord") and TITAN PHARMACEUTICALS, INC., a Delaware corporation ("Tenant"). 

 
 

RECITALS    
  

	A.
	Landlord
and Tenant have heretofore entered into that certain lease dated as of February 14, 1996 (the "Lease") for Suite 505, initially containing approximately 3,866 rentable
square feet, in the building located at 400 Oyster Point Boulevard, South San Francisco, California ("Building"), which forms part of the office building complex commonly known as Oyster Point Marina
Business Park (the "Complex"). Landlord and Tenant have entered into 1) that certain First Amendment dated as of March 25, 1997 for Suite 510, initially containing approximately 1,441
rsf, 2) that certain Second Amendment dated as of May 22, 1998 for Suites 515 and 512, consisting of 3,739 rsf and 961 rsf, respectively, 3) that certain Third Amendment dated as
of November 11, 2000 for temporary space located in Suite 203 consisting of 2,031 rsf and 4) that certain Fourth Amendment dated April 9. 2001 that added Suite 311 (2,396 rsf) and
Suite 516 (892 rsf), to the Premises and extended the Lease to June 30, 2005.

	E.
	The
parties mutually desire to modify the Lease, all on and subject to the terms and conditions hereof. 

 
 

AGREEMENT    
  

NOW
THEREFORE, in consideration of the mutual terms and conditions herein contained and of other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the
parties agree as follows: 

	1.
	Lease Extension: The lease is hereby extended for a period of one (1) years, commencing on July 1, 2005 and expiring on
June 30, 2006, or any earlier date upon which the Term may expire or be cancelled or terminated pursuant to any of the conditions or covenants of this Lease or pursuant to law.

	2.
	Added Premises. Tenant shall lease Suite 500 in 400 Oyster Point Boulevard consisting of 7,875 rsf, (the "Added Premises") for a period
of approximately fifty-three months, commencing on the date construction of tenant improvements for Suite 500 is substantially complete ("Added Premises Commencement Date") and expiring on
June 30, 2006 (the "Added Premises Expiration Date"). Promptly following the substantial completion of tenant improvements for the Added Premises, the parties hereto shall, if required by
Landlord, enter into a supplementary agreement fixing the date of the Commencement Date.

	3.
	Suite 311 Termination. Within fifteen (15) days of substantial completion of Added Premises, Tenant shall vacate Suite 311
consisting of 2,396 rsf and the lease and rent with respect to Suite 311 shall terminate. Landlord shall have the right to charge holdover rent as specified in the Lease for Suite 311 after said
fifteen-day period.

	4.
	Summary Table. The parties agree that the following table (the "Table One") sets forth in summary form the basic terms of Tenant's Lease
with the inclusion of the Added Premises including the specific space comprising Added Premises, with respect to such space, the Term of 

1

 

the
Lease, the usable and rentable square footage, the Base Rent, Base Year, and the Tenant's Share, as all of such terms as defined below: 

	PERIOD
 
	 	PREMISES
	 	RSF
	 	USF
	 	MONTHLY

BASE RENT
	 	T'S SHARE

BLDG/COMP
	 	BASE

YEAR

	Commencement Date to 6/30/02	 	500, 505 & 516	 	18,774	 	16,325	 	$45,996.30	 	8.1%/4.04%	 	1998
	7/1/02 to 6/30/03	 	500, 505 & 516	 	18,774	 	16,325	 	$51,628.50	 	8.1%/4.04%	 	2000
	7/1/03 to 6/30/04	 	500, 505 & 516	 	18,774	 	16,325	 	$56,322.00	 	8.1%/4.04%	 	2000
	7/1/04 to 6/30/05	 	500, 505 & 516	 	18,774	 	16,325	 	$61,015.50	 	8.1%/4.04%	 	2000
	7/1/05 to 6/30/06	 	500, 505 & 516	 	18,774	 	16,325	 	$64,770.30	 	8.1%/4.04%	 	2000

In
the event of any conflict between the terms contained in the Table and the terms contained in the body of the Lease or elsewhere in this Agreement, the terms of the Table as modified elsewhere by
this Agreement shall control throughout the Term. 

	6.
	Base Rent. The "Base Rent" reserved under this Lease, for the Term thereof, shall consist of Forty-Five Thousand Nine
Hundred Ninty-Six and 30/100s per month from the Commencement Date to June 30, 2002; Fifty-One Thousand Six Hundred Twenty-Eight and 50/100's ($51,628.50) per month from
July 1, 2002 to June 30, 2003; Fifty-Six Thousand Three Hundred Twenty-Two and 00/100 Dollars ($56,322.00) per month from July 1, 2003 to June 30,
2004, Sixty-One Thousand Fifteen and 50/100 Dollars ($61,015.50) per month from July 1, 2004 to June 30, 2005 and Sixty-Four Thousand Seven Hundred Seventy and
30/100's ($64,770.30) per month from July 1, 2005 to June 30, 2006.

	7.
	Tenant Improvements: Landlord shall provide a Tenant Improvement Allowance of One Hundred Twenty-Four Thousand Two Hundred
Seventy-Five and 95/100's Dollars ($124,275.95) toward tenant improvements in the Premises and Added Premises inclusive of i) $106,358.05 in construction costs,
ii) $12,000.00 in architectural, design and permitting costs and iii) $5,917.90 in project management fee (5% of TIs). Tenant shall pay for the carpet alternate ($8,745.00) of DA Pope's
bid dated November 19, 2001. Tenant's Work shall be governed by the Work Letter Agreement attached on Amendment Two with the exception of the above-mentioned Tenant Improvement Allowance.

	8.
	Early Entry: Tenant shall be permitted to enter the Added Premises prior to the Added Premises Commencement Date to perform install
Tenant's phone and cabling systems and furniture partitions. Tenant shall comply with all terms and condition of the Lease, except those provision requiring payment of Rent.

	9.
	Base Year: The Base Year for the Premises and Added Premises shall be 1998 until June 30, 2002 and 2000 commencing July 1,
2002.

	10.
	Option to Extend. The Option to Extend the Lease for two years specified in Paragraph 1.7 of the Lease shall apply to the period
July 1, 2006 to June 30, 2008.

	11.
	Security Deposit: The Security Deposit shall remain the same.

	12.
	No Offer: Submission of this Agreement is not an offer to enter into the same but a solicitation for such an offer by Tenant. Tenant
agrees that its execution of this Agreement constitutes a firm offer to enter the same that may not be withdrawn for a period of thirty (30) working days after delivery to Landlord. Landlord
shall not be bound by this Agreement until Landlord has executed and delivered
the same to Tenant. This Agreement shall not be relied upon by any other party, individual, corporation, partnership, or other entity as a basis for termination its lease with Landlord. 

2

 
	13.
	Defined Terms: Terms used herein that are defined in the Lease shall have the meanings therein defined, unless a different definition
is set forth in this Agreement. In the event of any conflict between the provisions of the Lease and this Agreement, the terms of this Agreement shall prevail.

	14.
	Survival: Warranties, representations, agreements, and obligations contained in this Agreement shall survive the execution and delivery
of this Agreement and shall survive any and all performances in accordance with this Agreement.

	15.
	Counterparts: This Agreement may be executed in any number of counterparts, which each severally and all together shall constitute one
and the same Agreement.

	16.
	Attorneys' Fees: If any party obtains a judgment against any other party or parties by reason of breach of this Agreement, reasonable
attorneys' fees and costs as fixed by the court shall be included in such judgment against the losing party or parties.

	17.
	Successors: This Agreement and the terms and provisions hereof shall inure to the benefit of and be binding upon the heirs, successors,
and assigns of the parties.

	18.
	Whole Agreement: The mutual obligations of the parties as provided herein are the sole consideration for this Agreement, and no
representations, promises, or inducements have been made by the parties other than as appear in this Agreement. This Agreement may not be amended except in writing signed by all the parties. 

IN
WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written. 

	Landlord:	 	Kashiwa Fudosan America, Inc., a California corporation
	

 	
 	

By:	
 	

/s/  HARU TAKEHANA      
 Mr. Haru Takehana
	 	 	Its:	 	Vice President
	
Tenant:	
 	
Titan Pharmaceuticals, Inc., a Delaware corporation
	

 	
 	

By:	
 	

/s/  SUNIL BHONSLE      
 Mr. Sunil Bhonsle
	 	 	Its:	 	Executive Vice President & COO

3

QuickLinks

Exhibit 10.18

FIFTH AMENDMENT

RECITALS

AGREEMENT

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