Document:

Modification to Commercial Promissory Note Agreement

 EXHIBIT10.43 
  
 THIRD MODIFICATION TO COMMERCIAL PROMISSORY 
 NOTE AND LOAN AND SECURITY AGREEMENT 
  
 THIS THIRD MODIFICATION TO COMMERCIAL PROMISSORY NOTE AND LOAN AND SECURITY AGREEMENT (“Modification”) is made and entered into as of
this 30th day of January, 2004 by and between SALIX PHARMACEUTICALS, LTD., a Delaware corporation and
SALIX PHARMACEUTICALS, INC., a California corporation (collectively, jointly and severally, “Borrower”) and RBC CENTURA BANK (“Bank”). 
  
 RECITALS 
  
 Bank made a loan to Borrower pursuant to the terms of a Commercial Promissory Note dated September 30, 2002 in the original principal amount of up to
Seven Million Dollars ($7,000,000.00) (with all amendments and modifications thereto, the “Note”) and a Loan and Security Agreement dated September 30, 2002 (with all amendments and modifications thereto, the “Loan
Agreement”; and with the Note and all other instruments, documents and agreements delivered in connection with the Note or Loan Agreement, or securing the same, and all amendments and modifications thereto, collectively the “Loan
Documents”). Borrower has requested Bank extend the current term of the Loan made pursuant to the Loan Documents, and to modify certain covenants within this Loan Agreement, and Bank has agreed to do so as set forth below. 
  
 NOW, THEREFORE, for and in consideration of the mutual promises herein
contained, and other good and valuable consideration, the receipt and independent sufficiency of which are hereby acknowledged, the parties agree as follows: 
  

1. Incorporation of Recitals. The foregoing Recitals are hereby incorporated in this Modification. 
  
 2. Modification to Note; Conforming Modification of Loan Agreement.
The Maturity Date is hereby extended until January 31, 2005, and in connection therewith, Section 2.1 of the Note is hereby deleted in its entirety, and a new Section 2.1 is inserted in lieu thereof, reading as follows: 
  
 “Section 2.1 Interest Payment Terms. Interest shall be payable
monthly, in arrears, beginning October 10, 2002 and continuing on the same calendar day of each consecutive month thereafter until January 31, 2005 (the “Maturity Date”), when all accrued but unpaid interest is due and payable in
full.” 
  
 In furtherance thereof, the “Revolving Maturity Date”,
as defined in Exhibit A to the Loan Agreement is hereby modified to be and mean January 31, 2005. 
  
 3. Modification to Loan Agreement. The “Maximum Quarterly Loss” financial covenant contained in the Loan Agreement is hereby removed, and
in connection therewith, Section 6.9(b) of the Loan Agreement is hereby deleted in its entirety. 
  
 4. Fees and Expenses. Bank’s agreement to extend the Maturity Date of the Note and to make the foregoing modifications and amendments is
subject in all respects to Borrower’s payment of a modification/renewal fee of Eight Thousand Five Hundred Dollars ($8,500.00), and all costs and expenses incurred or suffered by Bank in connection with this Agreement, including, without
limitation, attorneys’ fees. 
  
 5. Effect of
Modification. Nothing contained in this Modification shall in any way waive, annul, vary and affect any provision, condition, covenant and agreement contained in the Note and other Loan Documents, except as specifically modified herein, nor
affect and impair any rights, powers and remedies under the Loan Documents. The Note, as modified by this Modification, and the other Loan Documents contain the entire agreement of the parties hereto and the undersigned does hereby ratify, confirm
and reaffirm the terms of, and their respective agreements, obligations and duties under, each of the Note, Loan Agreement and other Loan Documents, all of which shall remain in full force and effect, as modified herein. This Modification shall be
binding upon any assignee and successor in interest of the parties hereto, and Borrower waives and will not assert against any transferee and assignee of Bank any claims, defenses, set-offs and rights of recoupment which Borrower could assert
against Bank, except defenses which Borrower cannot waive. 

 6. Miscellaneous. This Modification shall be deemed to have been executed and delivered in North
Carolina regardless of where the signatories may be located at the time of execution and shall be governed by and construed in accordance with the substantive laws of the State of North Carolina, excluding, however, the conflict of law provisions
thereof. This Modification may be executed in any number of counterparts with the same effect as if all parties hereto had signed the same document. All such counterparts shall be construed together and shall constitute one instrument, but in making
proof hereof it shall only be necessary to produce one such counterpart. It is the intention of the parties that this Modification and the Note, the other Loan Documents, and any other commitment letters, documents or agreements related to or
entered into in connection with the Loan Documents (or any of them), be interpreted in a consistent manner; provided, however, in the event of any irreconcilable conflict in the provisions of this Modification and the provisions of any of the Loan
Documents, the provisions of this Modification shall control. 
  
 IN WITNESS WHEREOF, the parties have caused this Modification to be executed with authority duly obtained, as of the date first written above. 
  

			
	 SALIX PHARMACEUTICALS, LTD., a Delaware corporation

		
	 By:
	 	 /s/ Adam C. Derbyshire

	 	 	

	 Print Name:
	 	 Adam C. Derbyshire

	 Title:
	 	 Sr. Vice President, Finance and Administration and CFO

	
	 SALIX PHARMACEUTICALS, INC., a California corporation

		
	 By:
	 	 /s/ Adam C. Derbyshire

	 	 	

	 Print Name:
	 	 Adam C. Derbyshire

	 Title:
	 	 Sr. Vice President, Finance and Administration and CFO

	
	 RBC CENTURA BANK

		
	 By:
	 	 /s/ Win Bear

	 	 	

	 Print Name:
	 	 Win Bear

	 Title:
	 	 Senior Account Manager

  
  

 2Amendment No. 6 to License and Distribution Agreement

 EXHIBIT 10.5I 
  
 AMENDMENT TO AGREEMENT 
  

			
	 HP Agreement No.: 4660000765
	 	 Amendment No.: 6

		
	 Supplier: Altiris, Inc.
	 	  
		
	 Effective Date of Amendment: January 1, 2004
	 	 

  
 This Amendment No. 6 (the
“Amendment”) to the License and Distribution Agreement dated November 12, 1999, also known as HP Agreement No. 4660000765, and as previously amended by the parties from time to time (the “Agreement”) is made by and between
Hewlett-Packard Company (“HP”) and Altiris, Inc. (“Altiris”) as of the Effective Date referenced above. 
  
 Whereas HP and Altiris desire to amend the Agreement and hereby agree as follows: 
  

	1.	All capitalized terms which are not defined in this Amendment shall have the meaning as ascribed to them in the Agreement. 

  

	2.	Section 9.5 of the Agreement is deleted in its entirety and replaced with the following language: 

  
 “License and Upgrade Fees for Internal Use—Deployment Solution. The license fee for a perpetual, Internal Use License of
Deployment Solution (previously known as Altiris eXpress) under Section 3.1 shall be [*]. Upgrade Protection, as set forth in Section 8.2 of the Agreement, is not included in such license fee. The license fee is payable by HP at the end of each
calendar quarter and is based on the number of nodes installed during such calendar quarter. If HP desires to receive Upgrade Protection for such licenses then HP shall pay an additional annual fee of [*] in advance of the annual Upgrade Protection
coverage period. Altiris reserves the right to increase the license fee or annual Upgrade Protection fee effective [*].” 
  

	3.	All other terms not expressly amended herein shall remain in full force and effect as set forth in this Agreement. Should a conflict arise between the Amendment and the Agreement,
the provisions of this Amendment shall control. 

  
 This Amendment
has been reviewed and accepted by the following parties as duly noted by signatures below. 
  

									
	 APPROVEDAND AGREED TO:
	 	 	 	 
			
	Hewlett-Packard Company (“HP”)	 	 	 	Altiris, Inc. (“Altiris”):
					
	By:	 	 /s/    Marie-Luce Vantyghem        
	 	 	 	By:	 	 /s/    Rob Wellman        

	 	 	
	 	 	 	 	 	

	 	 	Signature	 	 	 	 	 	Signature
					
	 Name:
	 	 Marie-Luce Vantyghem
	 	 	 	 Name:
	 	 Rob Wellman

	 Title:
	 	 Sol. Integration Mgr.
	 	 	 	 Title:
	 	 V.P. Strategic Alliance

	 Date:
	 	 March 4, 2004

	 	 	 	 Date:
	 	 March 2, 2004

  

			
	 Reviewed by Altiris Legal

	By:	 	 /s/    Eric Gardanier        

	 	 	

	 Date:
	 	 2/13/04                            

	 	 	

  

	[*]	This provision is the subject of a Confidential Treatment Request.Fifth Amendment to Lease Agreement

 EXHIBIT 10.6E 
  
 FIFTH AMENDMENT to LEASE AGREEMENT DATED 
 DECEMBER 31, 2001 
  
 [Canopy Properties, Inc. / Altiris, Inc.] 
  
 This FIFTH AMENDMENT is
entered into as of the twenty-third (23rd) day of January, 2004 between Canopy Properties, Inc. (“Landlord”) and Altiris, Inc. (“Tenant”). 
  

Whereas Landlord and Tenant entered into a Lease dated December 31, 2001, first amended 12 September 2002, and again 31 March 2003, 21 May 2003, and 31 Oct 2003, for
the purpose of increasing the premises, Landlord and Tenant hereby agree to further amend the Lease as follows: 
  
 1.1 Effective January 23, 2004, Tenant hereby surrenders to Landlord, and Landlord hereby accepts back from Tenant approximately 7,200 rentable square
feet of additional space (Additional Premises, Phase 2 of the Second Amendment to the Lease) identified as Suite 200, situated on the second floor of the Canopy Building III, located at 588 West 400 South, Lindon, Utah. 
  
 1.2 Effective January 23, 2004, Landlord hereby leases to Tenant and Tenant
hereby leases from Landlord approximately 8,103 rentable square feet of additional space (Additional Premises) identified as Suite 130, situated on the first floor of the Canopy Building III and represented on the attached drawing, Exhibit A,
located at 588 West 400 South, Lindon, Utah, bringing the approximate total lease space to 63,139 rentable square feet. 
  
 1.3 For purposes of clarification, the CPI escalation rate for base rent is hereby determined to be the CPI-U rate, Annualized and made public in early
January of each year, as published on the Bureau of Labor Statistics internet web page. 
  
 1.4 The Additional Premises in Paragraph 1.2 of this Amendment, shall be leased at the rate of $145,063.96, operating expenses as outlined in Paragraph 29 of the Lease included, except for the direct electrical costs
associated with the Computer Lab area located in the center of the Additional Premises, which shall be separately metered and billed extra as an additional rent; the base rent escalating at the Bureau of Labor Statistics published CPI-U rate each
remaining year of the term. 
  
 1.5 Upon this effective date, the
total annual rent for the Leased Premises shall be increased from $1,179,573.71, which includes the January 2004 CPI adjustment, to $1,195,739.64, for a net monthly increase of $1,347.16. 
  
 1.6 Tenant’s percentage share of operating cost at this effective date will be increased from 70.62% to 71.65%.

  
 2.1 Effective the earlier of: (i) January 1, 2005, or (ii)
upon completion of mutually agreed to Tenant Improvements (generally represented in the attached Exhibit B), or (iii) upon occupancy by Tenant should that occur first, Landlord hereby leases to Tenant and Tenant hereby leases from Landlord
approximately 7,200 rentable square feet of additional space (Additional Premises, Phase 2) identified as Suite 200, situated on the second floor of the Canopy Building III, located at 588 West 400 South, Lindon, Utah, bringing the approximate total
lease space to 70,339 rentable square feet. 

 2.2 These Additional Premises, Phase 2, shall be leased at the rate of $128,898.00 if effective before
January 1, 2005, or if on or after January 1, 2005, at $128,898.00 plus the 2004 CPI-U adjustment; operating expenses as outlined in Paragraph 29 of the Lease included, subsequently escalating at the Bureau of Labor Statistics published CPI-U rate
each remaining year of the term. 
  
 2.3 Upon this effective
date, the total annual rent for the Premises shall be adjusted by at least $128,898.00 to $1,324,637.64, for a net monthly increase of $10,741.50, plus the 2005 CPI-U adjustment, if applicable. 
  
 2.4 Tenant’s percentage share of operating cost at this effective date
will be increased from 70.62 % to 79.82%. 
  
 2.5 In the event
that Landlord has a firm offer to lease the Additional Premises, Phase 2, referred to in Paragraph 2.1 of this Lease Amendment prior to September 1, 2004, Landlord will first offer the space to Tenant under terms consistent with paragraph 2.2.
Tenant shall have ten (10) business days from notice of the offer to accept said offer to lease the space at that time. If Tenant does not accept the offer at that time, Landlord shall be free to lease said Additional Premises to a Third Party
through November 30, 2004. 
  
 All other terms, conditions and provisions of said
Lease, including the ending date of the initial term of the Lease, shall remain in full force and effect. 
  
  

									
	LANDLORD:	 	 	 	TENANT:
	Canopy Properties, Inc.	 	 	 	Altiris, Inc.
					
	By:	 	 /s/ Boyd Worthington

	 	 	 	By:	 	 /s/ Stephen C. Erickson

	Its:	 	VP, Real Estate Development	 	 	 	Its:	 	VP & Chief Financial Officer

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