Document:

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                                                                     Exhibit 4.6

THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE, AND MAY
BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED AND QUALIFIED
PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS OR IF
THE COMPANY IS PROVIDED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE
COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES
LAWS IS NOT REQUIRED OR IF THE COMPANY OTHERWISE SATISFIES ITSELF THAT
REGISTRATION IS NOT REQUIRED.

                   WARRANT TO PURCHASE SHARES OF COMMON STOCK

                                       OF

                               ALSIUS CORPORATION,
                            A CALIFORNIA CORPORATION

Date of Grant: April 13, 2006

     This certifies that for the purchase price paid, the undersigned holder of
this Warrant (the "Original Holder") and any person to whom the interest in this
Warrant is lawfully transferred (the Original Holder hereof and such transferees
referred to hereinafter as the "Holder"), is entitled to purchase up to that
number of shares of Common Stock, no par value (the "Common Stock") of Alsius
Corporation, a California corporation (the "Company") as determined pursuant to
Section 1(b) hereof, pursuant to the terms of this Warrant. This Warrant is
being issued in connection with a series of convertible promissory notes issued
by the Company on the Date of Grant of this Warrant (such notes, together with
convertible notes issued by the Company having substantially the same terms that
are later issued, the "Bridge Notes"). The Bridge Notes are automatically
convertible into Common Stock upon the closing of an underwritten public
offering of the Company's Common Stock (the "IPO").

     1. Exercise of Warrant.

          (a) Exercise Price; Aggregate Exercise Price. The price per share at
which this Warrant may be exercised (the "Exercise Price") will be equal to (i)
in the case of an IPO, the public offering price per share of Common Stock in
the IPO as stated on the front cover of the final IPO prospectus (before
deduction of any underwriting commissions, expenses or other amounts) or (ii) in
the event that an IPO or sale of the Company has not occurred prior to the
Maturity Date (as defined in the Bridge Notes) of the Bridge Notes, as described
below in this Section 1(a), the current $3.00 price per share of the Series F
Preferred Stock (as adjusted for stock splits, consolidations, recapitalizations
and the like that may occur after the date hereof).

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This Warrant will automatically become a Warrant to purchase shares of Series F
Preferred Stock if no IPO or sale of the Company causing conversion of the
Bridge Notes occurs prior to the Maturity Date of the Bridge Notes (including
any extension thereof in accordance with the terms of the Bridge Notes) and all
references to Common Stock in this Warrant shall become a reference to Series F
Preferred Stock. In the event of a Sale Transaction (as defined in the Bridge
Notes), this Warrant will be automatically cancelled. The initial "Aggregate
Exercise Price" will be the amount resulting from multiplying the Exercise Price
times the total number of shares of the stock that may be purchased upon
exercise hereof.

          (b) Number of Shares. Subject to the exercisability restrictions set
forth in Section 1(c) hereof, this Warrant will entitle the Holder to purchase
(i) in the event of an IPO, a number of shares of Common Stock equal to the
quotient obtained by dividing twenty percent (20%) of the original principal
amount of the Holder's Bridge Note by the public offering price per share of
Common Stock in the IPO as stated on the front cover of the final IPO prospectus
(before deduction of any underwriting commissions, expenses or other amounts),
and (ii) in the event that an IPO or Sale Transaction has not occurred prior to
the Maturity Date of the Bridge Notes, the quotient obtained by dividing twenty
percent (20%) of the original principal amount of the Holder's Bridge Note by
the $3.00 price per share of the Series F Preferred Stock (as adjusted for stock
splits, consolidations, recapitalizations and the like that may occur after the
date hereof).

          (c) Exercise Period. This Warrant will become exercisable on the
earlier of (i) closing of an IPO in which the Bridge Notes automatically convert
into Common Stock and (ii) the maturity date of the Bridge Notes (including any
extension thereof in accordance with the terms of the Bridge Notes) (the
"Exercise Date"). This Warrant will be exercisable for a period of three (3)
years from the Exercise Date.

          (d) Method of Exercise; Payment. The purchase right represented by
this Warrant may be exercised by the Holder, in whole or in part, for up to the
total number of shares remaining available for exercise by the surrender of this
Warrant (with the notice of exercise form attached hereto as Annex I duly
executed) at the principal office of the Company and by payment to the Company,
by: (i) check made payable to the Company drawn on a United States bank and for
United States funds, (ii) wire transfer of immediately available funds, (iii)
delivery to the Company of evidence of cancellation of indebtedness of the
Company to such Holder, or (iv) any combination thereof, of an amount in each
case equal to the then applicable Exercise Price per share multiplied by the
number of shares of Common Stock then being purchased. Upon partial exercise,
the Company will promptly issue an amended warrant representing the remaining
number of shares purchasable hereunder. All other terms and conditions of such
amended warrant will be identical to those contained herein, including, but not
limited to the effective date hereof.

          (e) Net Exercise. In the event that the Company's Common Stock is then
traded on a national securities exchange or admitted to unlisted trading
privileges on such an exchange, or is listed on the National Market (the
"National Market") of the National Association of Securities Dealers Automated
Quotations System (the "Nasdaq") or other over-the-counter quotation system,
this Warrant shall represent the right to purchase Common Stock and then the
Holder may elect to receive, without the payment by the Holder of any additional

                                      -2-

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consideration, shares equal to the value of this Warrant, or any portion hereof,
by the surrender of this Warrant or such portion to the Company (with the notice
of exercise form attached hereto as Annex I duly executed). Thereupon, the
Company will issue to the Holder such number of fully paid and nonassessable
shares of Common Stock as is computed using the following formula:

                                      Y (A - B)
                                  X = ---------
                                          A

          Where: X = The number of shares of Common Stock to be issued to the
                     Holder pursuant to this net exercise;

                 Y = The number of shares of Common Stock in respect of which
                     the net issue election is made;

                 A = The fair market value of one share of the Company's Common
                     Stock at the time the net issue election is made;

                 B = The Exercise Price in effect under this Warrant at the
                     time the net issuance election is made pursuant to this
                     Section 1(e).

     For purposes of this Section 1(e), the fair market value of one share of
the Company's Common Stock as of a particular date will be determined as
follows: (i) if traded on a securities exchange or through the Nasdaq National
Market, the value will be deemed to be the average of the closing prices of the
securities on such exchange for the ten (10) trading days ending on the trading
day prior to the net exercise election; and (ii) if traded over-the-counter, the
value will be deemed to be the average of the closing bid or sale prices
(whichever is applicable) for the ten (10) trading days ending on the trading
day prior to the net exercise.

          (f) Issuance of New Warrant. In the event of any exercise of the
purchase right represented by this Warrant, certificates for the shares of
Common Stock (or such other series of stock then issuable upon exercisable of
this Warrant) so purchased will be delivered to the Holder within fifteen (15)
business days after receipt of such payment and, unless this Warrant has been
fully exercised or has expired, a new warrant representing the portion of the
shares of Common Stock (or such other series of stock then issuable upon
exercisable of this Warrant), if any, with respect to which this Warrant will
not then have been exercised will also be issued to the Holder within a fifteen
(15) business day period.

     2. Adjustment of Number and Kind of Securities and Adjustment of Exercise
Price. The number and kind of securities purchasable upon the exercise of this
Warrant, and the Exercise Price, will be subject to adjustment from time to time
upon the occurrence of certain events, as follows:

          (a) Reclassification, Reorganization, Consolidation or Merger. In case
of any reclassification of the Common Stock of the Company, or any
reorganization, consolidation or merger of the Company with or into another
corporation (other than a merger or reorganization with respect to which the
Company is the continuing corporation and which does not result in any
reclassification of the Common Stock), the Company, or such successor
corporation, as the

                                      -3-

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case may be, will execute and deliver to the Holder a new warrant in
substitution for this Warrant which will provide that the Holder will have the
right to exercise such new warrant and upon such exercise to receive, in lieu of
each share of Common Stock issuable upon exercise of this Warrant, the number
and kind of securities, money and property receivable upon such
reclassification, reorganization, consolidation or merger by a holder of shares
of Common Stock of the Company for each share of Common Stock. Such new warrant
will provide for adjustments which will be as nearly equivalent as may be
practicable to the adjustments provided for in this Section 2 including, without
limitation, adjustments to the Exercise Price and to the number of shares
issuable upon exercise of this Warrant. The provisions of this Section 2(a) will
similarly apply to successive reclassifications, reorganizations, consolidations
or mergers. Notwithstanding the foregoing, pursuant to Section 1(a) hereof, this
Warrant shall automatically terminate upon a Sale Transaction.

          (b) Split, Subdivision or Combination of Shares. If the Company at any
time while this Warrant remains outstanding and unexpired splits, subdivides or
combines its Common Stock, the Exercise Price will be proportionately decreased
in the case of a split or subdivision or proportionately increased in the case
of a combination. Any adjustment under this Section 2(b) will become effective
when the split, subdivision or combination becomes effective.

          (c) Stock Dividends. If the Company at any time while this Warrant
remains outstanding and unexpired will pay a dividend with respect to the Common
Stock payable in shares of Common Stock, or securities convertible into or
exchangeable for Common Stock ("Convertible Securities"), the Exercise Price
will be adjusted, from and after the date of determination of the shareholders
entitled to receive such dividend or distribution, to that price determined by
multiplying the Exercise Price in effect immediately prior to such date of
determination by a fraction (i) the numerator of which will be the total number
of shares of Common Stock outstanding immediately prior to such dividend or
distribution, and (ii) the denominator of which will be the total number of
shares of Common Stock outstanding immediately after such dividend or
distributions (including shares of Common Stock issuable upon exercise,
conversion or exchange of any Convertible Securities issued as a dividend or
distribution). If the Convertible Securities issued as such dividend or
distributions by their terms provided, with the passage of time or otherwise,
for any increase or decrease in the consideration payable to the Company, or any
increase or decrease in the number of shares issuable upon exercise, conversion
or exchange thereof, or any change of rate or otherwise), the Exercise Price
will, upon any such decrease or increase becoming effective, be reduced or
increased to reflect such decrease or increase as if such decrease or increase
became effective immediately prior to the issuance of the Convertible Securities
as the dividend or distribution. Any adjustment under this Section 2(c) will
become effective on the record date or, if there is not record date, on the date
of issuance.

          (d) Adjustment of Number of Shares. Upon each adjustment in the
Exercise Price pursuant to this Section 2, the number of shares issuable upon
exercise of this Warrant will be adjusted to the number obtained by dividing the
then outstanding Aggregate Exercise Price by the Exercise Price immediately
after such adjustment.

     3. Compliance With Securities Act; Transferability of Warrant.

                                      -4-

<PAGE>

          (a) Legends. Any certificate for shares issued upon exercise hereof
will be imprinted with a legend in substantially the form set forth in the
Notice of Exercise form attached hereto as Annex I.

          (b) Restricted Securities. The Holder understands that the Warrant,
the Common Stock (the "Securities"), that the Holder is purchasing are
characterized as "restricted securities" under the federal securities laws,
inasmuch as they are being acquired from the Company in a transaction not
involving a public offering, and that under such laws and applicable regulations
such securities may be resold without registration under the Securities Act of
1933, as amended (the "1933 Act") only in certain limited circumstances. In this
connection, the Holder is familiar with Rule 144, as presently in effect, and
understands the resale limitations imposed thereby and by the 1933 Act. The
Holder understands Rule 144 is not currently available for the sale of the
Securities and may never be so available.

          (c) Transferability and Negotiability of Warrant. This Warrant may not
be transferred or assigned in whole or in part, unless (i) there is then in
effect a registration statement (declared effective by the Securities and
Exchange Commission) and necessary state regulatory authorities) under the 1933
Act covering such proposed disposition and such disposition is made in
accordance with such registration statement; or (ii) the Holder will have
notified the Company of the proposed disposition and will have furnished the
Company with a brief statement of the circumstances surrounding the proposed
disposition, and if reasonably requested by the Company, the Holder will have
furnished the Company with an opinion of counsel, reasonably satisfactory to the
Company that such disposition will not require registration of such shares under
the 1933 Act; provided however, no such registration or opinion will be
necessary for any transfer of this Warrant: (i) in compliance with Rule 144 or
Rule 144A of the 1933 Act, (ii) by gift, will or intestate succession by the
Holder to his or her spouse or lineal descendants or ancestors or any trust for
any of the foregoing or (iii) pursuant to a transfer to any partner, former
partner, affiliate, member or equity holder of the Holder or the estate of any
such partner, former partner, affiliate, member or equity holder of the Holder;
provided that, in each of the foregoing cases, the transferee agrees in writing
to be subject to the terms of this Warrant. Subject to the provisions of this
Section 3(c), title to this Warrant may be transferred in the same manner as a
negotiable instrument transferable by endorsement and delivery, by execution and
delivery of a completed Assignment Form attached hereto as Annex II.

     4. Representations and Warranties of the Holder. The Holder hereby
represents and warrants that:

          (a) Authorization. The Holder has full power and authority to enter
into this Warrant, and this Warrant constitutes the valid and legally binding
obligations of the Holder, enforceable in accordance with its terms.

          (b) Purchase Entirely for Own Account. The Securities will be acquired
for investment for the Holder's own account, not as a nominee or agent, and not
with a view to the resale or distribution of any part thereof, and the Holder
has no present intention of selling, granting any participation in or otherwise
distributing the same. The Holder does not have any contract, undertaking,
agreement or arrangement with any person to sell, transfer or grant
participation in any of the Securities to such person or to any third person.

                                      -5-

<PAGE>

          (c) Disclosure of Information. The Holder has received all the
information the Holder considers necessary or appropriate for deciding whether
to purchase this Warrant. The Holder has had an opportunity to ask questions and
receive answers from the Company regarding the terms and conditions of the
offering and sale of the Securities.

          (d) Investment Experience. The Holder is an investor in securities of
companies in the development stage and acknowledges that the Holder is able to
fend for himself and bear the economic risk of its investment, including the
complete loss thereof, and has such knowledge and experience in financial or
business matters that the Holder is capable of evaluating the merits and risks
of the investment in the Securities. The Holder acknowledges that the Company
currently is seeking investors to participate in a proposed offering of the
Company's securities, but there can be no assurances that the Company will find
financing on acceptable terms, if at all. The Holder has not been organized for
the purpose of acquiring the Securities.

          (e) Accredited Investor. The Holder is an "accredited investor" within
the meaning of Rule 501 of Regulation D, as presently in effect, promulgated
under the 1933 Act.

     5. Market Stand-Off Agreement. The Holder agrees to be bound by the market
stand-off agreement set forth in the Company's Investors' Rights Agreement (as
defined in the Bridge Notes), as the same may be amended from time to time.

     6. Replacement of Warrant. On receipt of evidence reasonably satisfactory
to the Company of the loss, theft, destruction, or mutilation of this Warrant
and, in the case of loss, theft, or destruction, on delivery of an indemnity
agreement reasonably satisfactory in form and substance to the Company or, in
the case of mutilation, on surrender and cancellation of this Warrant, the
Company at its expense will execute and deliver, in lieu of this Warrant, a new
warrant of like tenor and amount.

     7. Reservation of Stock. The Company covenants that during the term this
Warrant is exercisable, the Company will reserve from its authorized and
unissued Common Stock and Common Stock or Series F Preferred Stock, as the case
may be, a sufficient number of shares to provide for the issuance of Common
Stock or Series F Preferred Stock, as the case may be, upon the exercise of this
Warrant and, if applicable, the issuance of Common Stock upon conversion of the
Series F Preferred Stock and, from time to time, will take all steps necessary
to amend its Restated Articles to provide sufficient reserves of shares of
Common Stock or Series F Preferred Stock, as the case may be, issuable upon
exercise of the Warrant and, if applicable, Common Stock issuable upon
conversion of the Series F Preferred Stock. The Company agrees that its issuance
of this Warrant will constitute full authority to its officers who are charged
with the duty of executing stock certificates to execute and issue the necessary
certificates for shares of Common Stock or Series F Preferred Stock upon the
exercise of this Warrant.

     8. Notices. In case:

          (a) the Company will take a record of the holders of its Common Stock
(or other stock or securities at the time receivable upon the exercise of this
Warrant) for the purpose

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<PAGE>

of entitling them to receive any dividend or other distribution, or any right to
subscribe for or purchase any shares of stock of any class or any other
securities, or to receive any other right, or

          (b) of any capital reorganization of the Company, any reclassification
of the capital stock of the Company, any consolidation or merger of the Company
with or into another corporation, or any conveyance of all or substantially all
of the assets of the Company to another corporation, or

          (c) the closing of an IPO or the conversion of this Warrant into a
Warrant to purchase shares of Series F Preferred Stock, or

          (d) of any voluntary dissolution, liquidation of winding up of the
Company, then, and in each such case, the Company will mail or cause to be
mailed to the Holder or Holders a notice specifying, as the case may be, (A) the
date on which a record is to be taken for the purpose of such dividend,
distribution or right, and stating the amount and character of such dividend,
distribution or right, or (B) the date on which such reorganization,
reclassification, consolidation, merger, conveyance, dissolution, liquidation or
winding up is to take place, and the time, if any is to be fixed, as of which
the holders of record of Common Stock (or such stock or securities at the time
receivable upon the exercise of this Warrant) will be entitled to exchange their
shares of Common Stock (or such other stock or securities) for securities or
other property deliverable upon such reorganization, reclassification,
consolidation, merger, conveyance, dissolution, liquidation or winding up. Such
notice will be mailed at least fifteen (15) days prior to the date therein
specified.

     9. Rights of Shareholders. The Holder will not be entitled to vote or
receive dividends or be deemed the holder of Common Stock or any other
securities of the Company that may at any time be issuable on the exercise
hereof for any purpose, nor will anything contained herein be construed to
confer upon the Holder, as such, any of the rights of a shareholder of the
Company or any right to vote for the election of directors or upon any matter
submitted to shareholders at any meeting thereof, or to give or withhold consent
to any corporate action (whether upon any recapitalization, issuance of stock,
reclassification of stock, change of par value, or change of stock to no par
value, consolidation, merger, conveyance, or otherwise) or to receive notice of
meetings, or to receive dividends or subscription rights or otherwise until the
Warrant will have been exercised and the shares of Common Stock purchasable upon
the exercise hereof will have been issued, as provided herein.

     10. Fractional Shares. No fractional shares will be issued in connection
with any exercise hereunder, but in lieu of such fractional shares the Company
will make a cash payment therefor upon the basis of the Exercise Price then in
effect.

     11. Assignment. This Warrant applies to, inures to the benefit of, and
binds the successors and assigns of the parties hereto. Any transfer of this
Warrant will be effected only by surrender of this Warrant to the Company and
reissuance of a new note to transferee. The Holder and any subsequent holder(s)
of this Warrant receive this Warrant subject to the foregoing items and
conditions, and agree to comply with the foregoing terms and conditions for the
benefit of the Company and any other holders.

                                      -7-

<PAGE>

     12. Notices. Any notice, request or other communication required or
permitted hereunder will be in writing and will be deemed to have been duly
given (i) when received, if personally delivered, faxed, sent by nationally
recognized courier or U.S. Mail return-receipt requested, or (ii) on the third
(3rd) business day after deposit in the U.S. Mail, if sent by first-class mail,
in any such case to the address of the Holder set forth on the signature page
hereto and to the Company at Alsius Corporation, 15770 Laguna Canyon Road, Suite
150, Irvine, California 92618, Attention: President. Any party hereto may by
notice so given change its address for future notice hereunder.

     13. Warrant Register. This Warrant is transferable only upon the books of
the Company which it will cause to be maintained for such purpose. The Company
may treat the registered holder of this Warrant as he, she or it appears on the
Company's books at any time as the Holder for all purposes.

     14. Amendment, Waiver, Etc. The terms of this Warrant may be amended or
waived only upon the written agreement of the Company and the Holder; provided,
however, that during the time (and only during the time) the Bridge Notes are
outstanding, the terms of this Warrant and all of the other Warrants issued by
the Company in connection with the Bridge Notes may be amended or waived upon
the written agreement of the Company and the Holders of two-thirds or more of
the aggregate principal amount of all Bridge Notes (the "Supermajority
Holders"), whether or not the Holder of this Warrant agrees thereto, as long as
such amendment or waiver is the same for all Warrants. Any such amendment or
waiver agreed to by the Company and the Supermajority Holders during the time
the Bridge Notes are outstanding will be binding on the holders of all Warrants.
Amendments or waivers to which the Company and the Supermajority Holders may
agree, and which will be binding on holders of all Warrants, include, but are
not limited to, (i) shortening the term of the Warrants, (ii) changing the
exercise price of the Warrants, or (iii) reducing the number of shares for which
the Warrants are exercisable (as long as such reduction is proportionally the
same for each Warrant holder based on the shares covered by such holder's
Warrant relative to the shares covered by all Warrants).

     15. Heading; References. All headings used herein are used for convenience
only and will not be used to construe or interpret this Warrant. Except where
otherwise indicated, all references herein to Sections refer to Sections hereof.

     16. Severability. If any provision or set of provisions of this Warrant (or
any portion thereof) is held by an arbitrator or court of competent jurisdiction
to be invalid, illegal or unenforceable for any reason whatever: (a) such
provision will be limited or modified in its application to the minimum extent
necessary to avoid the invalidity, illegality or unenforceability of such
provision and such modified provision will be reduced to a writing and signed by
the parties hereto; (b) the validity, legality and enforceability of the
remaining provisions of this Warrant will not in any way be affected or impaired
thereby; and (c) to the fullest extent possible, the provisions of this Warrant
will be construed so as to give effect to the intent manifested by the provision
(or portion thereof) held invalid, illegal or unenforceable.

     17. Effect of Amendment or Waiver. Each Holder acknowledges that by the
operation of Section 14 hereof, less than all of the Holders of Warrants (or
such transferees of Warrants) may effect an amendment or waiver of provisions of
the Warrants and may therefore

                                      -8-

<PAGE>

diminish or eliminate all rights of such Holder under this Warrant even though
such Holder has not consented to the amendment or waiver.

     18. Governing Law. This Warrant will be governed by and construed in
accordance with the laws of the State of California, without regards to its
conflict of laws provisions.

                  [Remainder of page intentionally left blank]

                                      -9-

<PAGE>

     IN WITNESS WHEREOF, the undersigned have caused this Warrant to be executed
by the undersigned as of the date first set forth above.

                                        ALSIUS CORPORATION,
                                        a California corporation

                                        By:
                                            ------------------------------------
                                            William J. Worthen
                                            President and Chief Executive
                                            Officer

                                        HOLDER:

                                        [INVESTOR]

                                        By:
                                            ------------------------------------
                                        Name:
                                              ----------------------------------
                                        Title:
                                               ---------------------------------
                                        Address:
                                                 -------------------------------
                                        Fax:
                                             -----------------------------------
                                        Phone:
                                               ---------------------------------

                                      -10-

<PAGE>

                                     ANNEX I
                                   TO WARRANT

                           Warrant Notice of Exercise

Ladies/Gentlemen:

On this date the undersigned, ______________________________, hereby acquires
from Alsius Corporation, a California corporation (the "Company"), an aggregate
of _____________ shares of Common Stock (as defined in the Warrant) or Series F
Preferred Stock (as defined in the Warrant), as the case may be, which is
exercised hereby (the "Restricted Securities").

1. Investment Intent. The undersigned represents and warrants that:

     (a) The Restricted Securities have been acquired by the undersigned for
investment and not with a view to the sale or other distribution thereof within
the meaning of the Securities Act of 1933, as amended (the "1933 Act") and the
undersigned has no present intention of selling or otherwise disposing of all or
any portion of the Restricted Securities.

     (b) The undersigned has acquired the Restricted Securities for the
undersigned's own account and no one else has any beneficial ownership in the
Restricted Securities.

2. Restrictions on Transfer. The undersigned understands that:

     (a) In reliance upon the representations and warranties set forth herein,
the Restricted Securities have not been registered with the Securities and
Exchange Commission, and accordingly may not be offered, sold or otherwise
transferred except in compliance with the 1933 Act (including any exemptions
from registration thereunder);

     (b) The undersigned must bear the economic risk of the undersigned's
investment in the Restricted Securities indefinitely unless and until the
Restricted Securities are registered pursuant to the 1933 Act or, in the opinion
of counsel in form and substance satisfactory to the Company, an exemption from
the registration requirement is available;

     (c) The undersigned cannot be assured that any exemption from the
registration requirement will be available should the undersigned desire to
transfer the Restricted Securities, and, therefore, the undersigned may not be
able to dispose of or otherwise transfer the Restricted Securities, under the
circumstances, in the amounts, or at the time proposed by the undersigned; and

     (d) Rule 144 promulgated under the 1933 Act, which provides for certain
limited, routine sales of unregistered securities, is not presently available
with respect to the Restricted Securities, and the Company is under no
obligation to furnish the information that might be necessary to enable the
undersigned to sell any of the Restricted Securities under Rule 144.

3. Legend and Stop-Transfer Orders. The undersigned understands that, if
required by applicable federal securities laws at the date of issuance of the
Restricted Securities, certifies or other instruments representing any of the
Restricted Securities acquired by the undersigned will

<PAGE>

bear a legend substantially similar to the following, in addition to any other
legends required by federal or state laws, or by any contractual agreement
binding upon the undersigned with respect to the Restricted Securities:

     THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER
     THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY
     STATE, AND MAY BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED
     AND QUALIFIED PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE
     SECURITIES LAWS OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL
     REASONABLY SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION
     UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT REQUIRED OR IF THE COMPANY
     OTHERWISE SATISFIES ITSELF THAT REGISTRATION IS NOT REQUIRED.

     The undersigned agrees that, to ensure and enforce compliance with the
restrictions imposed by applicable law and those referred to in the foregoing
legend, or elsewhere herein, the Company may issue appropriate "stop transfer
instructions to its transfer agent, if any, with respect to any certificate or
other instrument representing Restricted Securities, or if the Company transfers
its own securities, that it may make appropriate notation to the same effect in
the Company's records.

     Notwithstanding the legend above, no registration statement or opinion of
counsel will be necessary for any transfer of Restricted Securities: (i) in
compliance with Rule 144 or Rule 144A of the 1933 Act, (ii) by gift, will or
intestate succession by the Holder to his or her spouse or lineal descendants or
ancestors or any trust for any of the foregoing or (iii) pursuant to a transfer
to any partner, former partner, affiliate or the estate of any such partner of
the Holder; provided that, in each of the foregoing cases, the transferee agrees
in writing to be subject to the terms of the Warrant.

-------------------------------------
(Printed name if entity)
(Signature of Individual)

(Please fill in and sign below only
if entity):

By:
    ---------------------------------
    (Signature)
Printed name:
              -----------------------
Its:
     --------------------------------
Date:
      -------------------------------

<PAGE>

                                    ANNEX II
                                   TO WARRANT

                 ASSIGNMENT FORM FOR ALSIUS CORPORATION WARRANT

     TO ASSIGN THE FOREGOING WARRANT, EXECUTE THIS FORM AND SUPPLY REQUIRED
INFORMATION. DO NOT USE THIS FORM TO EXERCISE THE WARRANT TO PURCHASE SHARES.

     PLEASE NOTE: THE WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED, OR UNDER THE APPLICABLE STATE SECURITIES LAWS. THE WARRANT
IS SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE
TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE WARRANT.

FOR VALUE RECEIVED, the foregoing Warrant for the purchase of capital stock of
Alsius Corporation and all rights evidenced thereby are hereby assigned to

Name of assignee:
                  --------------------------------------------------------------
Address of assignee:
                     -----------------------------------------------------------

                     -----------------------------------------------------------
Date:
      ---------------------------------
Assigning Holder's Name:
                         -------------------------------------------------------

Assigning Holder's Signature:
                              --------------------------------------------------
Assigning Holder's Address:
                            ----------------------------------------------------

                            ----------------------------------------------------

The name and signature of the assigning Holder must be exactly the same as the
Holder's name appears on the face of the assigned warrant, without alteration or
enlargement or any change whatever. Officers of corporations and those acting in
fiduciary or their representative capacity should file with this Assignment
proper evidence of their authority to so act.<PAGE>

                                                                     Exhibit 4.7

THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE, AND MAY
BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED AND QUALIFIED
PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE SECURITIES LAWS OR IF
THE COMPANY IS PROVIDED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE
COMPANY THAT REGISTRATION AND QUALIFICATION UNDER FEDERAL AND STATE SECURITIES
LAWS IS NOT REQUIRED OR IF THE COMPANY OTHERWISE SATISFIES ITSELF THAT
REGISTRATION IS NOT REQUIRED.

THIS 8% UNSECURED CONVERTIBLE PROMISSORY NOTE (THIS "NOTE") IS SUBORDINATED TO
THE COMPANY'S REPAYMENT OBLIGATIONS TO OXFORD FINANCE CORPORATION. THE TERMS OF
REPAYMENT UNDER THIS NOTE SHALL BE SUBJECT TO THE TERMS OF A SUBORDINATION
AGREEMENT AMONG THE COMPANY, OXFORD FINANCE CORPORATION AND THE UNDERSIGNED.

                               ALSIUS CORPORATION,
                            A CALIFORNIA CORPORATION

                    8% UNSECURED CONVERTIBLE PROMISSORY NOTE

                              DUE DECEMBER 31, 2006

Principal Amount $_________                                       April 13, 2006

     FOR VALUE RECEIVED, ALSIUS CORPORATION, a California corporation (the
"Company"), hereby promises to pay to the undersigned holder (the "Holder"), or
its registered assigns, the principal amount advanced to the Company hereunder,
up to the total principal amount stated above.

     1. (a) Bridge Financing. This 8% Unsecured Convertible Promissory Note (the
"Note") is part of a series of notes of like tenor which are being issued by the
Company on or about the date hereof in connection with a bridge financing of the
Company of up to $6 million (such notes are collectively referred to as the
"Bridge Notes"). In the event that, after the initial issuance of the Bridge
Notes, the Company elects to increase the bridge financing by issuing additional
convertible promissory notes having the same terms as this Note, except for a
later issuance date, then the issuance of such additional notes will require the
approval of the holders of two-thirds of the principal amount of all Bridge
Notes (the "Supermajority Holders") and, after such approval, such notes will
also be considered Bridge Notes for purposes hereof. THE RIGHTS OF REPAYMENT OF
THE HOLDER OF THIS NOTE AND THE HOLDERS OF ALL OTHER BRIDGE NOTES ARE
SUBORDINATED TO THE RIGHT OF OXFORD FINANCE CORPORATION, A LENDER TO THE
COMPANY, TO BE REPAID ALL PRINCIPAL, INTEREST, EXPENSES AND OTHER AMOUNTS OWED
TO SUCH LENDER, CURRENTLY

<PAGE>

APPROXIMATELY $4.3 MILLION. UNDER SECTION 23 HEREOF, THE HOLDER AGREES TO SIGN A
SUBORDINATION AGREEMENT REASONABLY ACCEPTABLE TO OXFORD FINANCE CORPORATION.

          (b) Maturity; Repayment. Repayment of this Note will be made in lawful
money of the United States of America at the address of the Holder set forth on
the signature page hereto, or at such other place as the Holder may designate in
writing. Unless earlier converted pursuant to Section 2 hereof, the principal
advanced hereunder will be due and payable on the earliest to occur of (i)
December 31, 2006 (the "Maturity Date"), (ii) an Event of Default (as
hereinafter defined) or (iii) the closing of a Sale Transaction. Interest will
accrue on the unpaid principal sum at a rate of eight percent (8%) per annum.
Prepayment of principal and accrued interest may be made in whole or in part
from time to time without penalty only with the consent of the Supermajority
Holders, provided that prepayment may only be made on this Note if at the same
time prepayment is made on all Bridge Notes, with payment on each Bridge Note
made pro rata in proportion to the original principal amount of such Bridge Note
relative to the aggregate principal amount of all Bridge Notes.

          (c) Issuance of Promissory Notes or Other Securities with Superior
Terms. If, after the date hereof and prior to the earlier of the Maturity Date
or the full repayment or conversion of the Bridge Notes, the Company issues
additional promissory notes or other securities ("Senior Securities") that
provide superior rights to the holders of such Senior Securities than the Bridge
Notes, then the Bridge Notes shall be deemed automatically amended, without the
need for any action on the part of Company or the Holder, as of the date of the
issuance of the Senior Securities to confer such additional rights upon all
holders of Bridge Notes. At the written request of the Supermajority Holders,
the Company will exchange the Bridge Notes for amended and restated Bridge Notes
or such other documents as are necessary to evidence the additional rights
granted to the holders of Senior Securities.

     2. (a) Automatic Conversion Upon IPO. If, after the date hereof and prior
to the earlier of the Maturity Date or the full repayment or conversion of the
Bridge Notes, the Company closes an underwritten public offering of its Common
Stock (an "IPO"), then the entire principal amount of this Note and accrued
interest (calculated through the date that is ten (10) days prior to the closing
of the IPO) will be converted automatically, without the need for any action on
the part of Company or the Holder, into unregistered shares of Common Stock of
the Company concurrently with the closing of the IPO. The number of shares of
Common Stock issuable upon conversion of this Note will be calculated by
dividing the total of the principal amount of and accrued interest on this Note
(calculated through the date set forth above in this Section 2(a)) then
outstanding by 80% of the per share public offering price stated on the front
cover of the final prospectus for the IPO (before deduction of any underwriting
commissions, expenses or other amounts). The Company will give the Holder notice
of the intended closing of an IPO, including the public offering price, provided
that the failure to give such notice will not affect the automatic conversion of
this Note. In order to receive certificates representing the Common Stock, the
Holder must cause the original of this Note to be delivered to the Company, or
if lost, stolen or destroyed, an affidavit and, if reasonably requested by the
Company, a reasonable indemnity as to the lost, stolen or destroyed original of
this Note. Then, the Company will cause one or more stock certificates
evidencing the Holder's ownership of the number of conversion shares into which
the principal amount of, and interest accrued on, this Note has been

<PAGE>

converted to be delivered promptly to the Holder or as directed by the Holder.
From and after the IPO, this Note will represent only the right to receive
shares of Common Stock.

          (b) Repayment or Conversion Upon Sale Transaction. If, after the date
hereof and prior to the full repayment or conversion of the Bridge Notes, the
Company closes a Sale Transaction (as defined below), then the entire principal
amount of this Note and accrued interest (calculated through the date that is
ten (10) days prior to the closing of the Sale Transaction) shall become
immediately due and payable and will be repaid at the closing of such Sale
Transaction in an amount equal to 150% of such principal amount and accrued
interest (the "Sale Repayment"). The form of repayment of this Note in
connection with a Sale Transaction will be in the same form of consideration
(i.e., cash and/or stock) as is received by the other shareholders of the
Company in the Sale Transaction. The valuation of the acquirer's stock or any
other non-cash consideration used to repay the Note, will be made by mutual
agreement of the Company and the Supermajority Holders, or absent such
agreement, by an experienced professional appraiser selected by mutual agreement
of the Company and the Supermajority Holders. The Company will give the Holder
prior written notice of its intention to complete a Sale Transaction, stating
the principal terms of the transaction; however, the failure to give such notice
will not affect the repayment terms of this Note. "Sale Transaction" means (i)
any sale of all or substantially all of the assets of the Company, and (ii) any
stock purchase, consolidation, merger, exchange or other transaction or series
of related transactions pursuant to which holders of the outstanding voting
securities of the Company immediately prior to such consolidation, merger,
exchange or other transaction or series of transactions fail to hold equity
securities representing a majority of the voting power of the Company or
surviving entity immediately following such stock purchase, consolidation,
merger, exchange or other transaction or series of transactions. A Sale
Transaction will not include a change of ownership of the Company (whether or
not greater than fifty percent (50%)) that results from the sale of newly issued
securities of the Company for cash in a financing or series of related
financings. The acquirer in any Sale Transaction may require the Holder to
surrender the original of this Note, or if lost, stolen or destroyed, an
affidavit and, if reasonably requested by the Company, a reasonable indemnity as
to the lost, stolen or destroyed original of this Note, in order to receive the
Sale Repayment.

          (c) Conversion at Maturity. If, on or before the Maturity Date, this
Note is not repaid in full and there has not been an IPO or Sale Transaction,
then the principal amount of this Note and accrued interest (calculated through
the Maturity Date) will be converted automatically on the Maturity Date, without
the need for any action by the Company or the Holder, into shares of the
Company's current Series F Preferred Stock (the "Series F Preferred Stock"). The
number of shares of Series F Preferred Stock issuable upon conversion of this
Note will be calculated by dividing the total of the principal amount then
outstanding of and accrued interest on this Note (calculated through the
Maturity Date) by the current $3.00 price per share of the Series F Preferred
Stock (as adjusted for stock splits, consolidations, recapitalizations and the
like that may occur after the date hereof). In order to receive certificates
representing the Series F Preferred Stock issuable upon conversion of this Note,
the Holder must cause the original of this Note to be delivered to the Company,
or if lost, stolen or destroyed, an affidavit and, if reasonably requested by
the Company, a reasonable indemnity as to the lost, stolen or destroyed original
of this Note. Then, the Company will cause one or more stock certificates
evidencing the Holder's ownership of the number of conversion shares into which
the principal

<PAGE>

amount of, and interest accrued on, this Note has been converted to be delivered
promptly to the Holder or as directed by the Holder. From and after the Maturity
Date, this Note will represent only the right to receive shares of Series F
Preferred Stock.

     3. Default. If any of the following events (hereafter called "Events of
Default") occurs:

          (a) If the Company defaults in the payment of any principal or accrued
interest due under this Note within fifteen (15) days of the date the same
becomes due and payable, whether at maturity or by acceleration or otherwise; or

          (b) If the Company makes a general assignment for the benefit of
creditors; or

          (c) If the Company files a voluntary petition in bankruptcy, or
becomes insolvent or adjudicated bankrupt, or files any petition or answer
seeking any reorganization, arrangement, composition, readjustment, liquidation,
dissolution or similar relief under the present or any future federal bankruptcy
act or other applicable federal, state or other statute, law or regulation, or
files any answer admitting the material allegation of a petition filed against
the Company in such proceeding, or seeks or consents to or acquiesces in the
appointment of any trustee, receiver or liquidator of the Company or of all or
any substantial part of the properties of the Company, or the Company commences
the winding up or the dissolution or liquidation of the Company; or

          (d) If, within sixty (60) days after a court of competent jurisdiction
has entered an order, judgment or decree approving any complaint or petition
against the Company seeking reorganization, dissolution or similar relief under
the present or any future federal bankruptcy act or other applicable federal,
state or other statute, law or regulation, such order, judgment or decree has
not been dismissed or stayed pending appeal, or if, within sixty (60) days after
the appointment, without the consent or acquiescence of the Company, of any
trustee, receiver or liquidator of the Company or of all or any substantial part
of the properties of the Company, such appointment has not been vacated or
stayed pending appeal, or if, within sixty (60) days after the expiration of any
such stay, such appointment has not been vacated; or

          (e) In the event the Company (i) redeems, purchases or otherwise
acquires for value, any share or shares of its equity securities other than
shares issued to officers, directors, employees and consultants of the Company
pursuant to agreements giving the Company a right or duty to repurchase such
shares upon termination of employment with or service to the Company, (ii)
declares or pays any dividends on or declares or makes any other distribution
(other than a dividend payable on capital stock solely in shares of capital
stock) on account of any of its equity securities or sets apart any sum for any
such purpose, or (iii) repays any of the Bridge Notes other than a repayment
made with the consent of the Supermajority Holders concurrently made on all
Bridge Notes, with payment on each Bridge Note made pro rata in proportion to
the principal amount of such Bridge Note relative to the aggregate principal
amount of all Bridge Notes;

               then, and in each and every such case, the Supermajority Holders,
but not any individual holder of Bridge Notes, may by written notice to the
Company declare all

<PAGE>

amounts under this Note and all other Bridge Notes to be forthwith due and
payable (except that, in the case of an Event of Default under either Section
3(b), Section 3(c) or Section 3(d) hereof, this Note will become immediately due
and payable without notice, and in the case of a default under Section 3(e)(iii)
hereof, the Holder of this Note may by written notice declare all amounts under
this Note due and payable without needing the approval of the Supermajority
Holders) and thereupon the balance will become so due and payable, without
presentation, protest or further demand or notice of any kind, all of which are
hereby expressly waived. The Company will give prompt written notice to the
Holder of the occurrence or the approval by the Company or its Board of
Directors of any and all of the foregoing events.

     4. Representations, Warranties and Covenants of the Company. The Company
hereby represents, warrants and covenants that:

          (a) Organization, Good Standing, Qualification. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of California, has all requisite corporate power and authority to
own and operate its properties and assets and to carry on its business as now
conducted and as proposed to be conducted, to execute and deliver this Note and
the Warrant to be issued in connection with the Bridge Notes (the "Warrant"), to
issue and sell the Common Stock, or Series F Preferred Stock, as the case may
be, issuable upon conversion of this Note, and the Common Stock issuable upon
conversion thereof, and the Common Stock issuable upon exercise of the Warrants
(collectively, the "Securities"), and to carry out the provisions of this Note
and the Warrant. The Company is qualified to transact business as a foreign
corporation and is in good standing under the laws of California and under the
laws of each jurisdiction where its ownership, lease or operation of property or
the conduct of its business requires such qualification, except to the extent
that failure to so qualify would not have a material adverse effect on the
Company.

          (b) Authorization. All corporate action on the part of the Company,
its officers, directors and shareholders necessary for the authorization,
execution and delivery of this Note and the Warrant, the performance of all
obligations of the Company hereunder and thereunder at the closing of the bridge
financing of which this Note is a part (the "Closing") and the authorization,
issuance (or reservation for issuance), sale and delivery of the Securities has
been taken or will be taken prior to the Closing (except for the authorization
of additonal equity needed for the conversion of the Notes, as contemplated by
Section 5(f) hereof), and this Note and the Warrant constitute valid and legally
binding obligations of the Company, enforceable in accordance with their
respective terms except (a) as limited by applicable bankruptcy, insolvency,
reorganization, moratorium and other laws of general application affecting
enforcement of creditors' rights generally, (b) as limited by laws relating to
the availability of specific performance, injunctive relief or other equitable
remedies.

          (c) Capitalization. The authorized capital of the Company consists of:

               (i) Preferred Stock. 11,538,655 shares of Preferred Stock (the
     "Preferred Stock"), 718 shares of which have been designated Series A
     Preferred Stock, all of which are currently issued and outstanding; 148
     shares of which have been designated Series B Preferred Stock, all of which
     are currently issued and outstanding; 1,582,546 shares of which have been
     designated Series C-D Preferred Stock, 1,582,026

<PAGE>

     shares of which are currently issued and outstanding; 1,422,435 shares of
     Series E Preferred Stock, all of which are currently issued and
     outstanding; and 8,532,808 shares of which have been designated Series F
     Preferred Stock, 8,319,141 shares of which are issued and outstanding.

               (ii) Common Stock. 16,000,000 shares of Common Stock of which
     56,984 shares are issued and outstanding. Except for (i) the conversion
     privileges of the Series A, Series B, Series C-D, Series E and Series F
     Preferred Stock; (ii) warrants to purchase 414,554 shares of Common Stock;
     (iii) warrants to purchase 116,667 shares of Series F Preferred Stock; (iv)
     the rights provided in paragraph 2.3 of the Tenth Amended and Restated
     Investor Rights Agreement, dated September 2, 2004, among the Company,
     certain investors and other specified holders named therein (the
     "Investors' Rights Agreement"); (v) rights granted in the Second Amended
     and Restated Right of First Refusal and Co-Sale Agreement, dated September
     2, 2004, among the Company, certain investors and other specified holders
     named therein; and (vi) 1,923,701 shares issuable pursuant to options
     granted under the Company's stock incentive plans or otherwise. The Company
     has reserved 2,100,000 shares of its Common Stock for purchase upon
     exercise of options granted or available for grant under the 2004 Plan.
     Except as set forth in the Eighth Amended and Restated Articles of
     Incorporation (the "Restated Articles"), the Investor Rights Agreement and
     the Shareholders Agreement, dated September 2, 2004, among the Company,
     certain investors and other specified holders named therein, the Company is
     not a party or subject to any agreement or understanding, and, to the best
     of the Company's knowledge, there is no agreement or understanding between
     any persons that affects or relates to the voting or giving of written
     consents with respect to any security or the voting by a director of the
     Company.

               (iii) Securities Law Compliance. The outstanding shares of Common
     Stock and Preferred Stock have been issued in accordance with the
     registration or qualification provisions of the Securities Act of 1933, as
     amended (the "1933 Act") and any relevant state securities laws or pursuant
     to valid exemptions therefrom and have been duly authorized and validly
     issued and are fully paid and nonassessable, and have been issued in
     compliance with applicable federal and state securities laws.

          (d) Valid Issuance. The Securities, when issued, sold and delivered in
accordance with the terms of this Note and the Warrant for the consideration
expressed herein and therein, will be duly and validly issued, fully paid and
nonassessable, and will be free and clear of any pledges, liens and encumbrances
in favor of the Company and of restrictions on transfer other than restrictions
on transfer under this Note, the Warrant and under applicable state and federal
securities laws as presently in effect.

          (e) Offering. Subject in part to the truth and accuracy of the
Holder's representations set forth in this Note and the Warrant, the offer, sale
and issuance of this Note, the Common Stock or Series F Preferred Stock, as the
case may be, as contemplated by this Note and the issuance of the Common Stock
to be issued upon conversion thereof, the Warrant and the Common Stock issuable
upon exercise of the Warrant, are exempt from the registration requirements of
the 1933 Act, and neither the Company nor any authorized agent acting on its
behalf will take any action hereafter that would cause the loss of such
exemption.

<PAGE>

          (f) Compliance With Other Instruments. The execution, delivery and
performance by the Company of this Note and the Warrant, the issuance (or
reservation for issuance) of the Securities, and the consummation of the
transactions contemplated hereby and thereby will not (i) result in any
violation or default of any provision of its Restated Articles or Bylaws, (ii)
result in a violation or default in any material respect of any provision of any
mortgage, agreement, instrument or contract to which it is a party or by which
it is bound or, to the best of its knowledge, of any federal or state judgment,
order, writ, decree, statute, rule or regulation applicable to the Company, or
(iii) constitute, with or without the passage of time or giving of notice, an
event that results in the creation of any material lien, charge or encumbrance
upon any assets of the Company or the suspension, revocation, impairment,
forfeiture or nonrenewal of any material permit, license, authorization or
approval applicable to the Company, its business or operations, or any of its
assets or properties.

          (g) Reservation of Stock. The Company covenants that in the event this
Note is convertible into Series F Preferred Stock, the Company will use its best
efforts to (i) reserve from its authorized and unissued Series F Preferred
Stock, and Common Stock issuable upon conversion thereof, a sufficient number of
shares to provide for the issuance of Series F Preferred Stock upon the
conversion of this Note or (ii) take all necessary steps to amend its Restated
Articles to provide sufficient reserves of shares of Series F Preferred Stock
issuable upon conversion of this Note, and shares of its Common Stock for
issuance on conversion thereof.

          (h) Amendment to Investors' Rights Agreement. Concurrent with the
execution and delivery of this Note, the Company and certain of the holders of
the Bridge Notes have amended that certain Tenth Amended and Restated Investors'
Rights Agreement, dated September 2, 2004, among the Company and the investors
named therein (the "Investors' Rights Agreement") to provide that all securities
issuable upon conversion of this Note and all securities issuable upon exercise
of the Warrants shall constitute "Registrable Securities" for purposes of such
agreement.

     5. Representations, Warranties and Covenants of the Holder. The Holder
hereby represents and warrants that:

          (a) Authorization. The Holder has full power and authority to enter
into this Note, and this Note constitutes the valid and legally binding
obligations of the Holder, enforceable in accordance with its terms.

          (b) Purchase Entirely for Own Account. The Securities will be acquired
for investment for the Holder's own account, not as a nominee or agent, and not
with a view to the resale or distribution of any part thereof, and the Holder
has no present intention of selling, granting any participation in or otherwise
distributing the same. The Holder does not have any contract, undertaking,
agreement or arrangement with any person to sell, transfer or grant
participation in any of the Securities to such person or to any third person.

          (c) Disclosure of Information. The Holder has received all the
information the Holder considers necessary or appropriate for deciding whether
to purchase the Securities. The Holder has had an opportunity to ask questions
and receive answers from the Company regarding the terms and conditions of the
offering and sale of the Securities.

<PAGE>

          (d) Investment Experience. The Holder is an investor in securities of
companies in the development stage and acknowledges that the Holder is able to
fend for himself and bear the economic risk of its investment, including the
complete loss thereof, and has such knowledge and experience in financial or
business matters that the Holder is capable of evaluating the merits and risks
of the investment in the Securities. The Holder acknowledges that the Company
currently is seeking investors to participate in a proposed offering of the
Company's securities, but there can be no assurances that the Company will find
financing on acceptable terms, if at all. The Holder has not been organized for
the purpose of acquiring the Securities.

          (e) Accredited Investor. The Holder understands the definition of, and
represents that the Holder is, an "accredited investor" as defined in Rule 501
of Regulation D, as presently in effect, promulgated under the 1933 Act.

          (f) Covenant of the Holder. The Holder agrees to execute and deliver
such documents and agreements and to vote either at a meeting of shareholders or
by written consent as may be reasonably requested from time to time by the
Company to carry out the obligations hereunder and under the Warrant, including,
but not limited to, all shareholder consents required in its capacity as a
Holder to increase the number of authorized shares of Series F Preferred Stock
and/or Common Stock.

     6. Restricted Securities. The Holder understands that the Securities that
the Holder is purchasing are characterized as "restricted securities" under the
federal securities laws, inasmuch as they are being acquired from the Company in
a transaction not involving a public offering, and that under such laws and
applicable regulations such securities may be resold without registration under
the 1933 Act only in certain limited circumstances. In this connection, the
Holder is familiar with Rule 144, as presently in effect, and understands the
resale limitations imposed thereby and by the 1933 Act. The Holder understands
Rule 144 is not currently available for the sale of the Securities and may never
be so available.

     7. Further Limitations on Disposition. Without in any way limiting the
representations set forth above, the Holder further agrees not to make any
disposition of all or any portion of the Securities (other than the valid
exercise or conversion thereof in accordance with their respective terms) unless
and until:

          (a) There is then in effect a registration statement under the 1933
Act covering such proposed disposition, and such disposition is made in
accordance with such registration statement; or if requested by the Company, the
Holder has furnished the Company with an opinion of counsel, reasonably
satisfactory to the Company, that such disposition will not require registration
of such Securities under the 1933 Act.

          (b) Notwithstanding the foregoing, no investment representation letter
or opinion of counsel will be required for any transfer of Securities (i) in
compliance with Rule 144 or Rule 144A of the 1933 Act, (ii) by gift, will or
intestate succession by the Holder to his or her spouse or lineal descendants or
ancestors or any trust for any of the foregoing or (iii) pursuant to a transfer
to any partner, former partner, affiliate, member or equity holder of the Holder
or the estate of any such partner, former partner, affiliate, member or equity
holder of the Holder;

<PAGE>

provided that, in each of the foregoing cases, the transferee agrees in writing
to be subject to the terms of this Note. In addition, if the Holder of any
Securities delivers to the Company an unqualified opinion of counsel that no
subsequent transfer of such Securities will require registration under the 1933
Act, the Company will, upon such contemplated transfer, promptly deliver new
documents/certificates for such Securities that do not bear the legend set forth
in Section 8(a) hereof.

     8. Legends. It is understood that the certificates evidencing the
Securities may bear one or more of the following legends:

          (a) The following legend under the 1933 Act:

     "THESE SECURITIES HAVE NOT BEEN REGISTERED OR QUALIFIED UNDER THE
     SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE,
     AND MAY BE OFFERED, SOLD, PLEDGED OR HYPOTHECATED ONLY IF REGISTERED AND
     QUALIFIED PURSUANT TO THE RELEVANT PROVISIONS OF FEDERAL AND STATE
     SECURITIES LAWS OR IF THE COMPANY IS PROVIDED AN OPINION OF COUNSEL
     REASONABLY SATISFACTORY TO THE COMPANY THAT REGISTRATION AND QUALIFICATION
     UNDER FEDERAL AND STATE SECURITIES LAWS IS NOT REQUIRED OR IF THE COMPANY
     OTHERWISE SATISFIES ITSELF THAT REGISTRATION IS NOT REQUIRED."

          (b) Any legend required by state securities laws.

               The Company agrees to remove promptly, upon the request of the
Holder of Securities issued upon conversion of this Note, the legend set forth
in Section 8(a) hereof from the documents/certificates for such Securities upon
full compliance with this Note, Rules 144 and 145 under the 1933 Act and any
other applicable provisions of the 1933 Act.

     9. Market Stand-Off Agreement. The Holder agrees to be bound by the market
stand-off agreement set forth in the Company's Investors' Rights Agreement, as
the same may be amended from time to time.

     10. Assignment. This Note applies to, inures to the benefit of, and binds
the successors and assigns of the parties hereto. Any transfer of this Note will
be effected only by surrender of this Note to the Company and reissuance of a
new note to the transferee. The Holder and any subsequent holder(s) of this Note
receive this Note subject to the foregoing items and conditions, and agree to
comply with the foregoing terms and conditions for the benefit of the Company
and any other holders.

     11. Expenses. Irrespective of whether the Closing is effected, the Company
and the Holder will be solely responsible for paying its own costs and expenses
with respect to the negotiation, execution, delivery and performance of this
Note and the Warrant; provided, however, that the Company agrees to pay
reasonable fees and expenses of one counsel to all holders of Bridge Notes
actually incurred.

<PAGE>

     12. Notices. Any notice, request or other communication required or
permitted hereunder will be in writing and will be deemed to have been duly
given (i) when received, if personally delivered, faxed, sent by nationally
recognized courier or U.S. Mail return-receipt requested, or (ii) on the third
business day after deposit in the U.S. Mail, if sent by first-class mail, in any
such case to the address of the Holder set forth on the signature page hereto
and to the Company at Alsius Corporation, 15770 Laguna Canyon Road, Suite 150,
Irvine, California 92619, Attention: President. Any party hereto may by notice
so given change its address for future notice hereunder.

     13. No Shareholder Rights. Nothing contained in this Note will be construed
as conferring upon the Holder or any other person the right to vote or to
consent or to receive notice as a shareholder in respect of meetings of
shareholders for the election of directors of the Company or any other matters
or any rights whatsoever as a shareholder of the Company; and no dividends will
be payable or accrued in respect of this Note or the capital stock obtainable
hereunder until, and only to the extent that, this Note will have been
converted.

     14. Note Register. This Note is transferable only upon the books of the
Company which it will cause to be maintained for such purpose. The Company may
treat the registered holder of this Note as he, she or it appears on the
Company's books at any time as the Holder for all purposes.

     15. Loss, Etc., of Note. Upon receipt of evidence satisfactory to the
Company of the loss, theft, destruction or mutilation of this Note, and of
indemnity reasonably satisfactory to the Company if lost, stolen or destroyed,
and upon surrender and cancellation of this Note if mutilated, the Company will
execute and deliver to the Holder a new note of like date, tenor and
denomination.

     16. Amendment, Waiver, Etc. The terms of this Note may be amended or waived
only upon the written agreement of the Company and the Holder; provided,
however, that the terms of this Note and all of the Bridge Notes may be amended
or waived upon the written agreement of the Company and the Supermajority
Holders, whether or not the Holder of this Note agrees thereto, as long as such
amendment or waiver is the same for all Bridge Notes. Any such amendment or
waiver agreed upon by the Company and the Supermajority Holders will be binding
on the holders of all Bridge Notes. Amendments or waivers to which the Company
and the Supermajority Holders may agree, and which will be binding on holders of
all Bridge Notes, include, but are not limited to, (i) extending the maturity
date, (ii) converting principal and accrued interest on the Bridge Notes in
whole or in part into equity securities of the Company, whether or not an IPO
has occurred, or (iii) changing the terms of repayment of the Bridge Notes upon
a Sale Transaction, including reducing the premium payable; provided, however,
that no amendment to the Bridge Notes shall be effective if such amendment
violates any of the terms of the Subordination Agreement (as hereinafter
defined).

     17. Heading; References. All headings used herein are used for convenience
only and will not be used to construe or interpret this Note. Except where
otherwise indicated, all references herein to Sections refer to Sections hereof.

<PAGE>

     18. Governing Law. This Note will be governed by and construed in
accordance with the laws of the State of California, without regard to its
conflicts of laws provisions.

     19. Severability. If any provision or set of provisions of this Note (or
any portion thereof) is held by an arbitrator or court of competent jurisdiction
to be invalid, illegal or unenforceable for any reason whatever: (a) such
provision will be limited or modified in its application to the minimum extent
necessary to avoid the invalidity, illegality or unenforceability of such
provision and such modified provision will be reduced to a writing and signed by
the parties hereto; (b) the validity, legality and enforceability of the
remaining provisions of this Note will not in any way be affected or impaired
thereby; and (c) to the fullest extent possible, the provisions of this Note
will be construed so as to give effect to the intent manifested by the provision
(or portion thereof) held invalid, illegal or unenforceable.

     20. Miscellaneous. The Company hereby waives presentment, demand, notice of
nonpayment, protest and all other demands and notices in connection with the
delivery, acceptance, performance or enforcement of this Note. If an action is
brought for collection under this Note, the Company will pay all costs of
collection actually incurred by a representative of the holders of a majority of
the principal amount of all Bridge Notes (the "Majority Holders"), including,
but not limited to, the reasonable attorneys' fees of a single counsel for all
holders of Bridge Notes selected by the Majority Holders.

     21. Warrant. As additional consideration for the issuance of this Note, the
Holder will receive the warrant attached hereto as Exhibit A.

     22. Effect of Amendment or Waiver. Each Holder acknowledges that, by the
operation of Section 16 hereof, less than all of the Holders of Bridge Notes (or
such transferees of Bridge Notes) may effect an amendment or waiver of
provisions of the Bridge Notes and may therefore diminish or eliminate rights of
such Holder under this Note even though such Holder has not consented to the
amendment or waiver.

     23. Oxford Subordination. The Holder agrees to sign such reasonable
subordination agreement (the "Subordination Agreement") as is required by Oxford
Finance Corporation and is reasonably acceptable to the Supermajority Holders,
to memorialize the subordination by the holders of Bridge Notes of their right
to be repaid to the repayment rights of Oxford Finance Corporation under its
loan agreements with the Company.

                         [Signatures on Following Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned have caused this 8% Unsecured
Convertible Promissory Note to be executed by the undersigned as of the date
first set forth above.

                                        ALSIUS CORPORATION,
                                        a California corporation

                                        By:
                                            ------------------------------------
                                            William J. Worthen
                                            President and Chief
                                            Executive Officer

                                        HOLDER:

                                        [INVESTOR]

                                        By:
                                            ------------------------------------
                                        Name:
                                              ----------------------------------
                                        Title:
                                               ---------------------------------
                                        Address:
                                                 -------------------------------
                                        Fax:
                                             -----------------------------------
                                        Phone:
                                               ---------------------------------

<PAGE>

                             SUBORDINATION AGREEMENT

     This Subordination Agreement (this "Agreement") is made as of April 13,
2006, among each of the holders of those certain 8% Unsecured Convertible
Promissory Notes listed on the attached Exhibit A ("Creditor"), Oxford Finance
Corporation ("Bank") and Alsius Corporation ("Borrower").

                                    Recitals

     B. Borrower has requested and/or obtained certain loans or other credit
accommodations from Bank, which are or may be from time to time secured by
assets and property of Borrower.

     C. Creditor intends to extend 8% unsecured convertible bridge financing to
Borrower.

     D. In order to comply with the terms and conditions of Bank's Master
Security Agreement No. 5051091 between Borrower and Bank and dated as of July
31, 2005, as amended from time to time in the manner set forth in Section 8
("Loan Agreement"), Creditor is willing to subordinate: (i) all of Borrower's
indebtedness and obligations to Creditor that will be issued as of April __,
2006 and evidenced by those certain "8% Unsecured Convertible Promissory Notes"
(the "Subordinated Debt") to all of Borrower's indebtedness and obligations to
Bank under the Loan Agreement; and (ii) all of Creditor's security interests, if
any, to all of Bank's security interests in the Borrower's property.

     E. Bank's consent to the Subordinated Debt, as is required under the Loan
Agreement, shall be conditioned upon each holder of Subordinated Debt signing
this Agreement.

     NOW, THEREFORE, THE PARTIES AGREE AS FOLLOWS:

     1. Creditor subordinates to Bank any security interest or lien that
Creditor may have in any property of Borrower. Notwithstanding the respective
dates of attachment or perfection of the security interest of Creditor and the
security interest of Bank, the security interest of Bank in the Collateral, as
defined in the Loan Agreement between Borrower and Bank, shall at all times be
prior to the security interest of Creditor.

     2. All Subordinated Debt is subordinated in right of payment to all
obligations of Borrower to Bank under the Loan Agreement (the "Senior Debt"),
together with all costs of collecting such obligations (including attorneys'
fees), including, without limitation, all interest accruing after the
commencement by or against Borrower of any bankruptcy, reorganization or similar
proceeding.

     3. Creditor will not demand or receive from Borrower (and Borrower will not
pay to Creditor) all or any part of the Subordinated Debt, by way of payment,
prepayment, setoff, lawsuit or otherwise, nor will Creditor exercise any remedy
with respect to the Collateral, nor will Creditor commence, or cause to
commence, prosecute or participate in any administrative, legal or equitable
action against Borrower, for so long as any portion of the Senior Debt remains
outstanding. Notwithstanding the foregoing, Creditor shall be entitled to
convert the

<PAGE>

Subordinated Debt into equity securities of Borrower pursuant to the terms of
the Subordinated Debt.

     4. Subject to Section 3 hereof, Creditor shall promptly deliver to Bank in
the form received (except for endorsement or assignment by Creditor where
required by Bank) for application to the Senior Debt any payment, distribution,
security or proceeds received by Creditor with respect to the Subordinated Debt
other than in accordance with this Agreement.

     5. In the event of Borrower's insolvency, reorganization or any case or
proceeding under any bankruptcy or insolvency law or laws relating to the relief
of debtors ("Insolvency Event"), these provisions shall remain in full force and
effect, and Bank's claims against Borrower and the estate of Borrower shall be
paid in full before any payment is made to Creditor.

     6. For so long as any of the Senior Debt remains unpaid, Creditor
irrevocably appoints Bank as Creditor's attorney-in-fact, and grants to Bank a
power of attorney with full power of substitution, in the name of Creditor or in
the name of Bank, for the use and benefit of Bank, with written notice to
Creditor, to perform at Bank's option the following act in any bankruptcy,
insolvency or similar proceeding involving Borrower:

          (a) To file the appropriate claim or claims in respect of the
Subordinated Debt on behalf of Creditor if Creditor does not do so prior to 30
days before the expiration of the time to file claims in such proceeding and if
Bank elects, in its sole discretion, to file such claim or claims.

     7. Creditor agrees that it will not take any action in any proceeding
related to an Insolvency Event inconsistent with the terms and conditions of
this Agreement, including the payment subordination provisions contained herein.
Creditor further agrees to promptly take such action as Bank may reasonably
request in furtherance thereof, including filing of claims or voting of claims
in any such proceeding related to an Insolvency Event in such manner as
reasonably directed by Bank to effectuate this Agreement.

     8. Creditor shall immediately affix a legend to the instruments evidencing
the Subordinated Debt stating that the instruments are subject to the terms of
this Agreement. No amendment of the documents evidencing or relating to the
Subordinated Debt shall directly or indirectly modify the provisions of this
Agreement in any manner which might terminate or impair the subordination of the
Subordinated Debt or the subordination of the security interest or lien that
Creditor may have in any property of Borrower. By way of example, such
instruments shall not be amended to (i) increase the rate of interest with
respect to the Subordinated Debt, or (ii) accelerate the payment of the
principal or interest or any other portion of the Subordinated Debt.

     9. This Agreement shall remain effective for so long as Borrower owes any
amounts to Bank under the Loan Agreement. If, at any time after payment in full
of the Senior Debt any payments of the Senior Debt must be disgorged by Bank for
any reason (including, without limitation, the bankruptcy of Borrower), this
Agreement and the relative rights and priorities set forth herein shall be
reinstated as to all such disgorged payments as though such payments had

<PAGE>

not been made and Creditor shall immediately pay over to Bank all payments
received with respect to the Subordinated Debt to the extent that such payments
would have been prohibited hereunder, but only up to the amount still owed to
Bank under the Senior Debt. At any time without notice to Creditor, Bank may
take actions it considers appropriate on the Senior Debt such as terminating
advances, increasing the principal, extending the time of payment, increasing
interest rates, renewing, compromising or otherwise amending any documents
affecting the Senior Debt and any collateral securing the Senior Debt, and
enforcing or failing to enforce any rights against Borrower or any other person.
No action or inaction will impair or otherwise affect Bank's rights under this
Agreement. No such action or inaction shall impair or otherwise affect Bank's
rights hereunder.

     10. This Agreement shall bind any successors or assignees of Creditor and
shall benefit any successors or assigns of Bank. This Agreement is solely for
the benefit of Creditor and Bank and not for the benefit of Borrower or any
other party. Creditor further agrees that if Borrower is in the process of
refinancing a portion of the Senior Debt with a new lender, and if Bank makes a
request of Creditor, Creditor shall agree to enter into a new subordination
agreement with the new lender on substantially the terms and conditions of this
Agreement.

     11. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original and all of which together shall constitute one
instrument.

     12. Virginia law shall govern this Agreement without giving effect to
conflicts of laws principles thereof. Creditor and Bank submit to the exclusive
jurisdiction of the State and Federal courts in the Commonwealth of Virginia.
CREDITOR AND BANK EACH WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE
OF ACTION FROM THIS AGREEMENT.

     13. This Agreement represents the entire agreement with respect to the
subject matter hereof, and supersedes all prior negotiations, agreements and
commitments. Creditor is not relying on any representations by Bank or Borrower
in entering into this Agreement, and Creditor has kept and will continue to keep
itself fully apprised of the financial and other condition of Borrower. This
Agreement may be amended only by written instrument signed by the holders of
two-thirds of the principal amount of all holders of Subordinated Debt and Bank.

     14. In the event of any legal action to enforce the rights of a party under
this Agreement, the party prevailing in such action shall be entitled, in
addition to such other relief as may be granted, all reasonable costs and
expenses, including reasonable attorneys' fees, incurred in such action.

<PAGE>

     IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the
date first above written.

                                        OXFORD FINANCE CORPORATION ("Bank")

                                        By:
                                            ------------------------------------
                                        Title:
                                               ---------------------------------

                                        ALSIUS CORPORATION ("Borrower")

                                        ----------------------------------------
                                        William J. Worthen
                                        President and Chief Financial Officer

<PAGE>

                                   "Creditor":

<PAGE>

                                    Exhibit A

                                List of Creditors

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