Document:

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                                                                   Exhibit 10.5

                               PANGEA SYSTEMS, INC

                      CHANGE OF CONTROL AND RETENTION PLAN

                                   ARTICLE 1.

                PURPOSE, ESTABLISHMENT AND APPLICABILITY OF PLAN

     (a) PURPOSES. It is expected that Pangea Systems, Inc. (the "Company"),
from time to time, will consider the possibility of a Change of Control. The
Board of Directors of the Company (the "Board") recognizes that such
consideration can be a distraction to the Employee or Executive and can cause
the Employee or Executive to consider alternative employment opportunities. The
Board believes that it is in the best interests of the Company and its
shareholders to provide the Employee or Executive with an incentive to continue
his employment and to maximize the value of the Company upon a Change of Control
for the benefit of its shareholders. Further, the Board believes that it is in
the best interests of the Company and its shareholders to provide an attractive
compensation package to attract and retain key personal. In order to provide the
Employee or Executive with enhanced financial security and sufficient
encouragement to remain with the Company notwithstanding the possibility of a
Change of Control, the Board believes that it is imperative to provide the
Employee or Executive with certain benefits upon a Change of Control and certain
severance benefits upon the Employee's or Executive's termination of employment
following a Change of Control.

     (b)  ESTABLISHMENT OF PLAN. As of the Effective Date, the Company
hereby establishes this Plan, as set forth in this document.

     (c)  APPLICABILITY OF PLAN.  Subject to the terms of this Plan, the
benefit provided by this Plan shall be available to all Employees and
Executives of the Company.

     (d)  CONTRACTUAL RIGHT TO BENEFITS. This Plan establishes and vests in
each Employee and Executive a contractual right to the benefits to which he
or she is entitled pursuant to the terms thereof, enforceable by the Employee
and Executive against the Company.

                                   ARTICLE 2.

                          DEFINITIONS AND CONSTRUCTION

         Whenever used in the Plan, the following terms shall have the meanings
set forth below.

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     (a) CAUSE. "Cause" shall mean (i) any act of personal dishonesty taken by
the Employee or Executive in connection with his responsibilities as an employee
which is intended to result in substantial personal enrichment of the Employee
or Executive, (ii) Employee's or Executive's conviction of a felony which the
Board reasonably believes has had or will have a material detrimental effect on
the Company's reputation or business, (iii) a willful act by the Employee or
Executive which constitutes misconduct and is injurious to the Company, and (iv)
continued willful violations by the Employee or Executive of the Employee's or
Executive's obligations to the Company after there has been delivered to the
Employee or Executive a written demand for performance from the Company which
describes the basis for the Company's belief that the Employee or Executive has
not substantially performed his duties.

     (b) CHANGE OF CONTROL. "Change of Control" shall mean the occurrence of any
of the following events:

         (i) the approval by shareholders of the Company of a merger or
consolidation of the Company with any other corporation, other than a merger or
consolidation which would result in the voting securities of the Company
outstanding immediately prior thereto continuing to represent (either by
remaining outstanding or by being converted into voting securities of the
surviving entity) more than fifty percent (50%) of the total voting power
represented by the voting securities of the Company or such surviving entity
outstanding immediately after such merger or consolidation;

        (ii) any approval by the shareholders of the Company of a plan of
complete liquidation of the Company or an agreement for the sale or disposition
by the Company -of all or substantially all of the Company's assets; or

       (iii) any "person" (as such term is used in Sections 13(d) and 14(d) of
the Securities Exchange Act of 1934, as amended) becoming the "beneficial
owner" (as defined in Rule 13d-3 under said Act), directly or indirectly, of
securities of the Company representing 50% or more of the total voting power
represented by the Company's then outstanding voting securities.

     (c) EMPLOYEE. "Employee" shall mean an employee of the Company who is not
an Executive.

     (d) EXECUTIVE. "Executive" shall mean an officer of the Company of the
vice-presidential level or above, any non-employee director and those persons
designated by the Board as listed on Exhibit A, which may be amended from time
to time.

     (e) INVOLUNTARY TERMINATION. "Involuntary Termination" shall mean (i)
without the Employee's or Executive's express written consent, a significant
reduction of the Employee's or Executive's duties, position or responsibilities
relative to the Employee's or Executive's duties, position or responsibilities
in effect immediately prior to the

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Change of Control, or the removal of the Employee or Executive from such
position, duties and responsibilities, unless the Employee or Executive is
provided with comparable duties, position and responsibilities; provided,
however, that a reduction in duties, position or responsibilities solely by
virtue of the Company being acquired and made part of a larger entity (as, for
example, when the Chief Financial Officer of the Company remains as such
following a Change of Control but is not made the Chief Financial Officer of the
acquiring corporation) shall not constitute an "Involuntary Termination; (ii)
without the Employee's or Executive's express written consent, a substantial
reduction of the facilities and perquisites (including office space and
location) available to the Employee or Executive immediately prior to the Change
of control; (iii) a reduction by the Company of the Employee's or Executive's
base salary as in effect immediately prior to the Change of Control; (iv) a
material reduction by the Company in the kind or level of employee benefits to
which the Employee or Executive is entitled immediately prior to the Change of
Control with the result that the Employee's or Executive's overall benefits
package is significantly reduced; (v) without the Employee's or Executive's
express written consent, the relocation of the Employee or Executive to a
facility or a location more than thirty-five (35) miles from his current
location; (vi) any purported termination of the Employee or Executive by the
Company which is not effected for Cause for which the grounds relied upon are
not valid; or (vii) the failure of the Company to obtain the assumption of this
Plan, by any successors contemplated in Section 5 below.

     (f) OPTION. "Option" shall mean an option granted by the Board pursuant to
the Company's 1996 Equity Incentive Plan.

     (g) PLAN. "Plan" shall mean this Change of Control and Retention Plan.

     (h) TERMINATION DATE. "Termination Date" shall mean the effective date of
any notice of termination delivered by one party to the other hereunder.

                                   ARTICLE 3.

                                  TERM OF PLAN

         TERM OF  PLAN. This Plan shall terminate upon the date that all
obligations of the parties hereto under this Plan have been satisfied.

                                   ARTICLE 4.

                    CHANGE OF CONTROL AND SEVERANCE BENEFITS

     (a) OPTION ACCELERATION UPON A CHANGE OF CONTROL FOR EMPLOYEES AND
EXECUTIVES. In the event of a Change of Control, each Option granted to an
Employee or Executive shall be assumed or an equivalent option substituted by
the successor

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corporation or a parent or subsidiary of the successor corporation. In the
event that the successor corporation or its parent or subsidiary refuses to
assume or substitute for the Option, the Employee or Executive shall fully
vest in and have the right to exercise the Option, including shares as to
which it would not otherwise be vested or exercisable. If an Option becomes
fully vested and exercisable in lieu of assumption or substitution in the
event of a Change of Control, the Company shall notify the Employee or
Executive in writing at least fifteen (15) days prior to the Change of
Control that the Option shall be fully exercisable (contingent upon the
Change of Control) for a period of fifteen (15) days from the date of such
notice, and the Option shall terminate upon the expiration of such period.
For the purposes of this paragraph, the Option shall be considered assumed
if, following the merger or sale of assets, the Option confers the right to
purchase or receive, for each share subject to the Option immediately prior
to the Change of Control, the consideration (whether stock, cash, or other
securities or property) received in the merger or sale of assets by holders
of Common Stock for each share held on the effective date of the transaction
(and if holders were offered a choice of consideration, the type of
consideration chosen by the holders of a majority of the outstanding shares);
provided, however, that if such consideration received in the merger or sale
of assets is not solely common stock of the successor corporation or its
parent, the Company may, with the consent of the successor corporation,
provide for the consideration to be received upon the exercise of the Option,
for each share subject to the Option, to be solely common stock of the
successor corporation or its parent equal in fair market value to the per
share consideration received by holders of common stock in the merger or sale
of assets. Notwithstanding the above, if it is determined by the Company's
independent public accountants (the "Accountants") that such acceleration
would preclude accounting for the Change of Control as a pooling of interests
for financial accounting purposes, and it is a condition to the closing of
the Change of Control that the transaction be accounted for as a pooling of
interests, then the vesting and exercisability of the Options shall not
accelerate pursuant to this Section 4(a).

     (b) OPTION ACCELERATION UPON A CHANGE OF CONTROL FOR EXECUTIVE'S. Upon a
Change of Control, the vesting and exercisability of each Option granted to an
Executive by the Company (the "Options") shall be automatically accelerated as
to 50% of the shares subject thereto at the time of the Change of Control, but
which are not vested at such time; provided, however, that if it is determined
by the Company's Accountants that such acceleration would preclude accounting
for the Change of Control as a pooling of interests for financial accounting
purposes, and it is a condition to the closing of the Change of Control that the
transaction be accounted for as a pooling of interests, then the vesting and
exercisability of the Options shall not accelerate pursuant to this Section
4(b).

     (c) TERMINATION OF EXECUTIVES FOLLOWING A CHANGE OF CONTROL. If the
Executive's employment with the Company terminates as a result of an Involuntary
Termination within twelve (12) months of a Change in Control, the vesting and
exercisability of each Option granted to an Executive by the Company shall be

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automatically accelerated as to 50% of the shares subject thereto at the
Termination Date, but which are not vested at such time; provided, however, that
if it is determined by the Company's Accountants that such acceleration would
preclude accounting for the Change of Control as a pooling of interests for
financial accounting purposes, and it is a condition to the closing of the
Change of Control that the transaction be accounted for as a pooling of
interests, then the vesting and exercisability of the Options shall not
accelerate pursuant to this Section 4(c).

     (d) TERMINATION OF EMPLOYEES FOR CAUSE. If an Employee's or Executive's
employment with the Company is terminated for Cause, the Employee or Executive
shall be permitted to exercise the Option for those shares underlying the Option
that have vested prior to the Termination Date; provided, however, that the
Employee or Executive exercises the option within 30 days of the Termination
Date. Notwithstanding the forgoing, if it is determined by the Company's
Accountants that the Section 4(d) would preclude accounting for the Change of
Control as a pooling of interests for financial accounting purposes, and it is a
condition to the closing of the Change of Control that the transaction be
accounted for as a pooling of interests, then this Section 4(d) shall be of no
effect.

                                   ARTICLE 5.

                                  SUCCESSORS

         COMPANY'S SUCCESSORS. Any successor to the Company (whether direct
or indirect and whether by purchase, lease, merger, consolidation,
liquidation or otherwise) to all or substantially all of the Company's
business and/or assets shall assume the Company's obligations under this Plan
and agree expressly to perform the Company's obligations under this Plan in
the same manner and to the same extent as the Company would be required to
perform such obligations in the absence of a succession. For all purposes
under this Plan, the term "Company" shall include any successor to the
Company's business and/or assets which executes and delivers the assumption
agreement described in this Article or which becomes bound by the terms of
this Plan by operation of law.

                                   ARTICLE 6.

                           GOLDEN PARACHUTE EXCISE TAX
                        AND NON-DEDUCTIBILITY LIMITATIONS

     (a) BENEFITS CAP. In the event that the benefits under this Plan, when
aggregated with any other payments or benefits received by an Employee or
Executive, or to be received by an Employee or Executive, would (i) constitute
"parachute payments" within the meaning of Section 280G of the Code, and (ii)
but for this provision, would be subject to the excise tax imposed by Section
4999 of the Code or any similar or successor provision, then the Employee's or
Executive's Plan benefits shall be

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reduced to such lesser amount or degree as would result in no portion of such
benefits being subject to the excise tax under Section 4999 of the Code.

     (b) DETERMINATION. Unless the Company and the Employee or Executive
otherwise agree in writing, any determination required under this Article shall
be made in writing by the Accountants, whose determination shall be conclusive
and binding upon the Employee or Executive and the Company for all purposes. For
purposes of making the calculations required by this Article, the Accountants
may make reasonable assumptions and approximations concerning applicable taxes
and may rely on reasonable, good faith interpretation concerning the application
of Sections 280G and 4999 of the Code. The Company and the Employee or Executive
shall furnish to the Accountants such information and documents as the
Accountants may reasonably request in order to make a determination under this
Article. The Company shall bear all costs the Accountants may reasonably incur
in connection with any calculations contemplated by this Article.

                                   ARTICLE 7.

                                   NOTICES

     (a) GENERAL. Notices and all other communications contemplated by this Plan
shall be in writing and shall be deemed to have been duly given when personally
delivered or when mailed by U.S. registered or certified mail, return receipt
requested and postage prepaid. In the case of the Employee or Executive, mailed
notices shall be addressed to him at the home address which he most recently
communicated to the Company in writing. In the case of the Company, mailed
notices shall be addressed to its corporate headquarters, and all notices shall
be directed to the attention of its Secretary.

     (b) NOTICE OF TERMINATION. Any termination by the Company for Cause or by
the Employee or Executive as a result of a voluntary resignation or an
Involuntary Termination shall be communicated by a notice of termination to the
other party hereto given in accordance with this Section. Such notice shall
indicate the specific termination provision in this Plan relied upon, shall set
forth in reasonable detail the facts and circumstances claimed to provide a
basis for termination under the provision so indicated, and shall specify the
Termination Date (which shall be not more than 30 days after the giving of such
notice). The failure by the Employee or Executive to include in the notice any
fact or circumstance which contributes to a showing of Involuntary Termination
shall not waive any right of the Employee or Executive hereunder or preclude the
Employee or Executive from asserting such fact or circumstance in enforcing his
rights hereunder.

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                                   ARTICLE 8.

                                  ARBITRATION

     (a) Any dispute or controversy arising out of, relating to, or in
connection with this Plan, or the interpretation, validity, construction,
performance, breach, or termination thereof, shall be settled by binding
arbitration to be held in Alameda County, California, in accordance with the
National Rules for the Resolution of Employment Disputes then in effect of the
American Arbitration Association (the "Rules"). The arbitrator may grant
injunctions or other relief in such dispute or controversy. The decision of the
arbitrator shall be final, conclusive and binding on the parties to the
arbitration. Judgment may be entered on the arbitrator's decision in any court
having jurisdiction.

     (b) The arbitrator(s) shall apply California law to the merits of any
dispute or claim, without reference to conflicts of law rules. The arbitration
proceedings shall be governed by federal arbitration law and by the Rules,
without reference to state arbitration law. By signing and delivering to the
Company the Notice of Participation, the Employee or Executive consents to the
personal jurisdiction of the state and federal courts located in California for
any action or proceeding arising from or relating to this Plan or relating to
any arbitration in which the parties are participants.

     (c) The Company and Employee or Executive shall each pay one-half of the
costs and expenses of such arbitration, and each shall separately pay its
counsel fees and expenses.

     (d) Nothing in this Section modifies Employee's or Executive's at-will
employment status. Either Employee or Executive, or the Company can terminate
the employment relationship at any time, with or without cause.

     (e) SUBMITTING ANY CLAIMS ARISING OUT OF, RELATING TO, OR IN CONNECTION
WITH THIS PLAN, OR THE INTERPRETATION, VALIDITY, CONSTRUCTION, PERFORMANCE,
BREACH OR TERMINATION THEREOF TO BINDING ARBITRATION, CONSTITUTES A WAIVER OF
EMPLOYEE'S OR EXECUTIVE'S RIGHT TO A JURY TRIAL AND RELATES TO THE RESOLUTION OF
ALL DISPUTES RELATING TO ALL ASPECTS OF THE EMPLOYER/ EMPLOYEE OR EXECUTIVE
RELATIONSHIP, INCLUDING BUT NOT LIMITED TO, THE FOLLOWING CLAIMS:

        (i) ANY AND ALL CLAIMS FOR WRONGFUL DISCHARGE OF EMPLOYMENT; BREACH OF
CONTRACT, BOTH EXPRESS AND IMPLIED; BREACH OF THE COVENANT OF GOOD FAITH AND
FAIR DEALING, BOTH EXPRESS AND IMPLIED; NEGLIGENT OR INTENTIONAL INFLICTION OF
EMOTIONAL DISTRESS; NEGLIGENT OR INTENTIONAL

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MISREPRESENTATION; NEGLIGENT OR INTENTIONAL INTERFERENCE WITH CONTRACT OR
PROSPECTIVE ECONOMIC ADVANTAGE; AND DEFAMATION.

       (ii) ANY AND ALL CLAIMS FOR VIOLATION OF ANY FEDERAL STATE OR MUNICIPAL
STATUTE, INCLUDING, BUT NOT LIMITED TO, TITLE VII OF THE CIVIL RIGHTS ACT OF
1964, THE CIVIL RIGHTS ACT OF 1991, THE AGE DISCRIMINATION IN EMPLOYMENT ACT OF
1967, THE AMERICANS WITH DISABILITIES ACT OF 1990, THE FAIR LABOR STANDARDS ACT,
THE CALIFORNIA FAIR EMPLOYMENT AND HOUSING ACT, AND LABOR CODE SECTION 201, ET
SEQ.;

      (iii) ANY AND ALL CLAIM ARISING OUT OF ANY OTHER LAWS AND REGULATIONS
RELATING TO EMPLOYMENT OR EMPLOYMENT DISCRIMINATION.

                                   ARTICLE 9.

                            MISCELLANEOUS PROVISIONS

     (a) AT-WILL EMPLOYMENT. The Company and the Employee or Executive
acknowledge that the Employee's or Executive's employment is and shall continue
to be at-will, as defined under applicable law. If the Employee's or Executive's
employment terminates for any reason, the Employee or Executive shall not be
entitled to any payments, benefits, damages, awards or compensation other than
as provided by this Plan, or as may otherwise be established under the Company's
then existing employee benefit plans or policies at the time of termination.

     (b) NO DUPLICATIVE BENEFITS. To the extent that the terms of an Employee's
or Executive's Offer Letter provide for acceleration of options under terms
substantially similar to those in Sections 4(b) and (c) hereof, no duplicative
benefits shall be conferred upon such Employee or Executive.

     (c) NO DUTY TO MITIGATE. The Employee or Executive shall not be required to
mitigate the amount of any payment contemplated by this Plan, nor shall any such
payment be reduced by any earnings that the Employee or Executive may receive
from any other source.

     (d) WAIVER. No provision of this Plan may be modified, waived or discharged
unless the modification, waiver or discharge is agreed to by the Board. No
waiver by either party of any breach of, or of compliance with, any condition or
provision of this Plan by the other party shall be considered a waiver of any
other condition or provision or of the same condition or provision at another
time,

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     (e) CHOICE OF LAW. The validity, interpretation, construction and
performance of this Plan shall be governed by the internal substantive laws, but
not the conflicts of law rules, of the State of California.

     (f) SEVERABILITY. The invalidity or unenforceability of any provision or
provisions of this Plan shall not affect the validity or enforceability of any
other provision hereof, which shall remain in full force and effect.

     (g) EMPLOYMENT TAXES. All payments made pursuant to this Plan shall be
subject to withholding of applicable income and employment taxes.

     (h) COUNTERPARTS. This Plan may be executed in counterparts, each of which
shall be deemed an original, but all of which together will constitute one and
the same instrument.

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                                    EXHIBIT A

         Peter Karp<PAGE>

                       INDEMNIFICATION AGREEMENT

         THIS INDEMNIFICATION AGREEMENT (the "Agreement") is effective as of the
____ day of ________, 2000, by and between DoubleTwist, Inc., a Delaware
corporation (the "Company"), and _______________, an individual ("Indemnitee").

                                   BACKGROUND

         A. Indemnitee is [AN OFFICER/A MEMBER OF THE BOARD OF DIRECTORS] of the
Company and, in that capacity, performs a valuable service for the Company. For
a variety of reasons, including the frequency, magnitude and often baseless
nature of claims and actions brought against corporate directors and officers
generally, it is difficult for corporations to attract and retain highly
competent persons as directors and officers. In addition, there exists
uncertainty, both as to matters of "substance" and "procedure," about the
protection against such claims provided by statutory, charter and bylaw
provisions and through "director and officer" insurance.

        B. The Company's Certificate of Incorporation also provides for
indemnification of, and advancement of expenses to, the directors and officers
of the Company to the maximum extent authorized by the Delaware General
Corporation Law, as amended (the "DGCL"), and, together with the DGCL, permits,
by its nonexclusive nature, the establishment of indemnification agreements
between the Company and its directors and officers.

         C. In order to induce Indemnitee to continue to serve as [AN OFFICER/A
MEMBER OF THE BOARD OF DIRECTORS] of the Company and to clarify the specific
procedure for addressing indemnification matters if and as they arise, the
Company and the Indemnitee hereby agree to contractual indemnification
arrangements on the terms set forth in this Agreement.

         THE PARTIES AGREE AS FOLLOWS:

         1. DEFINITIONS. For purposes of this Agreement, the following terms
have the following meanings:

                           a. "Agent" means any person (i) who is or was a
director, officer, employee or other agent of the Company or (ii) who is or was
serving at the request of the Company, or otherwise as a result of that person's
relationship with the Company, as a director, officer, employee or other agent
of another foreign or domestic corporation or of any partnership, joint venture,
trust or other enterprise (including, without limitation, service with respect
to employee benefit plans).

                           b. "Change in Control" shall be deemed to have
occurred if (i) any "person" (as such term is used in Sections 13(d) and 14(d)
of the Securities Exchange Act of 1934, as amended), other than a trustee or
other fiduciary holding securities under an employee benefit plan of the Company
or a corporation owned directly or indirectly by the stockholders of the Company
in substantially the same proportions as their ownership of stock of the
Company, becomes the "beneficial owner" (as defined in Rule 13d-3 under said
Act), directly or indirectly, of securities of the Company representing 20% or
more of the total voting power represented by

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the Company's then outstanding Voting Securities, or (ii) during any period of
two consecutive years, individuals who at the beginning of such period
constitute the Board of Directors of the Company and any new director whose
election by the Board of Directors or nomination for election by the Company's
stockholders was approved by a vote of at least two-thirds (2/3) of the
directors then still in office who either were directors at the beginning of the
period or whose election or nomination for election was previously so approved,
cease for any reason to constitute a majority thereof, or (iii) the stockholders
of the Company approve a merger or consolidation of the Company with any other
corporation, other than a merger or consolidation which would result in the
Voting Securities of the Company outstanding immediately prior thereto
continuing to represent (either by remaining outstanding or by being converted
into Voting Securities of the surviving entity) at least 80% of the total voting
power represented by the Voting Securities of the Company or such surviving
entity outstanding immediately after such merger or consolidation, or the
stockholders of the Company approve a plan of complete liquidation of the
Company or an agreement for the sale or disposition by the Company (in one
transaction or a series of transactions) of all or substantially all of the
Company's assets.

                           c. "Disinterested Director" means a director of the
Company who neither is nor was a party to the Proceeding in respect of which
indemnification is sought under this Agreement or otherwise.

                           d. "Expenses" includes any and all direct and
indirect costs (including, without limitation, attorneys' fees and
disbursements, court costs, fees and expenses of witnesses, experts,
professional advisers and private investigators, arbitration expenses, costs of
attachment, appeal or similar bonds, travel expenses, duplicating, printing and
binding costs, telephone charges, postage, delivery service fees, and any and
all other disbursements or out-of-pocket expenses) actually and reasonably
incurred by or on behalf of Indemnitee in connection with either (i) the
investigation, defense, settlement or appeal of, or being a witness or
participant in, a Proceeding (including preparing for any of the foregoing) or
(ii) the establishment or enforcement of any right to indemnification under this
Agreement or otherwise or any right to recovery under any liability insurance
policy maintained by the Company; PROVIDED, HOWEVER, that "Expenses" shall not
include any judgments, fines or amounts paid in settlement.

                           e. "Independent Counsel" means a law firm or attorney
that neither is presently nor in the past two years has been retained to
represent: (i) the Company or Indemnitee in any matter material to the Company
or Indemnitee, or (ii) any other party to the Proceeding in respect of which
indemnification is sought under this Agreement or otherwise. In addition, the
term "Independent Counsel" does not include any law firm or attorney who, under
the applicable standards of professional conduct then prevailing, would have a
conflict of interest in representing either the Company or Indemnitee in an
action to determine Indemnitee's right to indemnification under this Agreement
or otherwise.

                           f. "Liabilities" means liabilities and losses of any
type whatsoever, including, without limitation, judgments, fines, excise taxes
and penalties (including, without limitation, ERISA excise taxes and penalties)
and amounts paid in settlement (including all interest, assessments and other
charges paid or payable in connection with or in respect of such

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liabilities and losses), actually incurred by Indemnitee in connection with or
as a result of a Proceeding.

                           g. "Potential Change in Control" shall be deemed to
have occurred if (i) the Company enters into an agreement, the consummation of
which would result in the occurrence of a Change in Control; (ii) any person
(including the Company) publicly announces an intention to take or to consider
taking actions which, if consummated, would constitute a Change in Control;
(iii) any person, other than a trustee or other fiduciary holding securities
under an employee benefit plan of the Company or a corporation owned, directly
or indirectly, by the stockholders of the Company in substantially the same
proportions as their ownership of stock of the Company, who is or becomes the
beneficial owner, directly or indirectly, of securities of the Company
representing 9.5% or more of the combined voting power of the Company's then
outstanding Voting Securities, increases such person's beneficial ownership of
such securities by five percentage points or more over the initial percentage of
such securities equal to or exceeding 9.5% so owned by such person; or (iv) the
Board of Directors of the Company adopts a resolution to the effect that, for
purposes of this Agreement, a Potential Change in Control has occurred.

                           h. "Proceeding" means any threatened, pending or
completed action, suit or proceeding (including any inquiry, hearing,
arbitration proceeding or alternative dispute resolution mechanism), whether
civil, criminal, administrative or investigative (including any action by or in
the right of the Company), to which Indemnitee is or was a party, witness or
other participant, or is threatened to be made a party, witness or other
participant, by reason of the fact that Indemnitee is or was an Agent, or by
reason of anything done or not done by Indemnitee in that capacity or in any
other capacity while serving as an Agent, whether before or after the date of
this Agreement. "Proceeding" shall not include any Proceeding initiated by
Indemnitee (other than as contemplated by Sections 3(d) or 6 of this Agreement)
unless such Proceeding was authorized or consented to by the Board of Directors
of the Company.

                           i. "Voting Securities" means any securities of the
Company which vote generally in the election of directors.

         2. AGREEMENT TO INDEMNIFY. Subject to the terms and conditions of, and
in accordance with the procedures set forth in, this Agreement, the Company
shall hold Indemnitee harmless and indemnify Indemnitee (and Indemnitee's spouse
as provided below), to the fullest extent permitted by the provisions of the
DGCL and other applicable law, from and against all Expenses and Liabilities,
including, without limitation, Expenses and Liabilities arising from any
Proceeding brought by or in the right of the Company or its stockholders. The
Company and Indemnitee intend that this Agreement provide for indemnification in
excess of that expressly required, granted or permitted by statute, including,
without limitation, any indemnification provided by the Company's Certificate of
Incorporation or Bylaws, or by vote of its stockholders or directors, or by
applicable law. If, after the date hereof, the DGCL or any other applicable law
is amended to permit or authorize indemnification of, or advancement of defense
expenses to, Indemnitee to a greater extent than is permitted on the date
hereof, references in this Agreement

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to the DGCL or any other applicable law shall be deemed to refer to the DGCL or
such applicable law as so amended.

         3.       PROCEDURAL MATTERS.

                  a. INITIAL REQUEST. Whenever Indemnitee believes that, in a
specific case, Indemnitee is then entitled to indemnification under this
Agreement or under the Company's Certificate of Incorporation or Bylaws, the
DGCL or otherwise, Indemnitee shall submit a written notice to the Company
requesting an authorization and determination by the Company to that effect. The
notice shall describe the matter giving rise to the request and be accompanied
by all appropriate supporting documentation reasonably available to Indemnitee.

                  b. DETERMINATION AND PAYMENT. The Company shall make a
determination about Indemnitee's entitlement to indemnification in the specific
case no later than 90 days after receipt of Indemnitee's request. In making that
determination, the person or persons making the determination shall presume that
Indemnitee met any applicable standard of conduct required for indemnification,
unless the Company shall have affirmatively shown by clear and convincing
evidence that Indemnitee did not meet that standard. The determination shall be
made by the Board of Directors by a majority vote of a quorum consisting of
Disinterested Directors. If such a quorum is not obtainable, or, even if
obtainable, a quorum of Disinterested Directors so directs, the determination
shall be made by Independent Counsel in a written opinion obtained at the
Company's expense. Notwithstanding the foregoing, if there has been a Change in
Control (other than a Change in Control which has been approved by a majority of
the Company's Board of Directors who were directors immediately prior to such
Change in Control), the determination shall be made by Independent Counsel in a
written opinion obtained at the Company's expense. If the person or persons
empowered to make the determination either: (i) affirmatively makes a
determination of Indemnitee's entitlement to indemnification or (ii) fails to
make any determination at all within the 90-day period, indemnification shall be
considered as authorized and proper in the circumstances, and Indemnitee shall
be absolutely entitled to such indemnification, and shall receive payment as
promptly as practicable, in the absence of any misrepresentation of a material
fact by Indemnitee in the request for indemnification, or a specific
determination by a court of competent jurisdiction that all or any part of such
indemnification is prohibited by applicable law. If the person or persons
empowered to make the determination find that the Indemnitee is not entitled to
indemnification, the Indemnitee shall have the right to apply to a court of
competent jurisdiction for the purpose of enforcing Indemnitee's right to
indemnification pursuant to this Agreement. The termination of any Proceeding by
judgment, order, settlement, arbitration award, conviction or upon a plea of
NOLO CONTENDERE or its equivalent shall not, of itself, create a presumption
that Indemnitee did not act in good faith and in a manner which Indemnitee
reasonably believed to be in or not opposed to the best interests of the
Company, or that, with respect to any criminal Proceeding, Indemnitee had
reasonable cause to believe Indemnitee's conduct was unlawful.

                  c. ADVANCEMENT OF EXPENSES. If so requested in a writing by
Indemnitee accompanied by appropriate supporting documentation, the Company
shall, within ten days after receipt of the request, advance funds for the
payment of Expenses, whether that request is made

                                      -4-
<PAGE>

before or after the final disposition of a Proceeding (including, without
limitation, any criminal Proceeding or any Proceeding brought by or in the right
of the Company or its stockholders), unless there has been a final determination
that Indemnitee is not entitled to indemnification for those Expenses. If
required by law at the time of the advance, the payment of the advance shall be
conditioned upon the receipt from Indemnitee of an undertaking (which need not
be secured) to repay the advance to the extent that it is ultimately determined
that Indemnitee is not entitled to such indemnification by the Company. Any
dispute concerning the advancement of Expenses may, at the election of the
Indemnitee, be resolved by arbitration before an arbitrator selected by
Indemnitee and approved by the Company. If the parties cannot agree on a single
arbitrator, then the claim shall be heard by a panel of three arbitrators, with
one selected by Indemnitee, one selected by the Company and one selected jointly
by the foregoing two arbitrators. Each of the arbitrators shall be a litigation
or corporate attorney with experience in the field of officer and director
indemnification. The arbitrators shall be selected within (15) days after demand
for arbitration and shall render a decision within (45) days after selection,
unless good cause is shown for requiring a longer decision period. The Company
shall act in utmost good faith to provide timely information to the arbitrators
and to insure Indemnitee a full opportunity to defend against the Company's
claim that Indemnitee is not entitled to an advance of Expenses. The Company
shall indemnify Indemnitee against all Expenses incurred by Indemnitee under the
dispute resolutions proceedings set forth in this Subsection 3(c), unless a
court of competent jurisdiction finds that each of the claims and/or defenses by
Indemnitee in the action or proceeding for which an advance is sought was
frivolous or made in bad faith.

                  d. ENFORCEMENT. If Indemnitee has not received a determination
of entitlement to indemnification or an advance, as the case may be, within the
applicable time periods for such actions specified in this Agreement, or if it
has been determined that Indemnitee substantively would not be permitted to be
indemnified in whole or in part under applicable law, Indemnitee shall be
entitled to commence an action in any court of competent jurisdiction (including
the court in which the Proceeding (as to which Indemnitee seeks indemnification)
is or was pending) (i) in the former case, seeking enforcement of Indemnitee's
rights under this Agreement or otherwise, or seeking an initial determination by
the court, or (ii) in the latter case, challenging any such determination or any
aspect thereof, including the legal or factual bases therefor. The Company
hereby consents to service of process and to appear generally in any such
proceeding. It shall be a defense to any such action that applicable law does
not permit the Company to indemnify Indemnitee for the amount claimed. In any
such action, the Company shall have the burden of proving that indemnification
or advances are not proper in the circumstances of the specific case. Neither
the failure of the Company to have made a determination prior to the
commencement of such action that indemnification is proper under the
circumstances because Indemnitee has met the standard of conduct under
applicable law, nor an actual determination by the Company that Indemnitee has
not met such standard of conduct, shall be a defense to the action or create a
presumption that Indemnitee has not met that standard of conduct. The Company
shall indemnify Indemnitee for Expenses incurred by Indemnitee in connection
with the successful establishment or enforcement, in whole or in part, by
Indemnitee of Indemnitee's right to indemnification or advances.

                                      -5-
<PAGE>

                  e. NOTICE BY INDEMNITEE AND DEFENSE OF PROCEEDINGS. Indemnitee
shall promptly notify the Company in writing upon being served with any summons,
citation, subpoena, complaint, indictment, information or other document
relating to any matter which may give rise to a claim for indemnification under
this Agreement or otherwise; PROVIDED, HOWEVER, that a failure of Indemnitee to
provide that notice shall relieve the Company from liability only if and to the
extent that the failure materially prejudices the Company's ability to
adequately defend Indemnitee in the Proceeding. With respect to any Proceeding
as to which Indemnitee so notifies the Company:

                           i. The Company shall be entitled to participate at
its own expense.

                           ii. Except as otherwise provided below, the Company,
jointly with any other indemnifying party similarly notified, shall be entitled
to assume the defense of such Proceeding, with counsel reasonably satisfactory
to Indemnitee. After notice from the Company to Indemnitee of the Company's
election to assume the defense, the Company shall not be liable to Indemnitee
under this Agreement for any Expenses subsequently incurred by Indemnitee, other
than as provided below. Indemnitee shall have the right to employ Indemnitee's
own counsel in that Proceeding, but the fees and expenses of such counsel
incurred after notice from the Company of its election so to assume the defense
shall be borne by Indemnitee, except to the extent that (x) the employment of
counsel by Indemnitee has been authorized by the Company, (y) Indemnitee has
reasonably concluded that there may be a conflict of interest between the
Company and Indemnitee in the conduct of the defense of such Proceeding or that
counsel selected by the Company may not be adequately representing Indemnitee,
or (z) the Company has not in fact employed counsel to assume the defense of
such Proceeding. In those cases, the fees and expenses of Indemnitee's own
counsel shall be paid by the Company.

                           iii. Neither the Company nor Indemnitee shall
unreasonably withhold its or his or her consent to any proposed settlement. The
Company has no obligation to indemnify and hold Indemnitee harmless under this
Agreement for any amounts paid in settlement of any Proceeding effected without
its written consent. The Company shall not settle any Proceeding in any manner
which would impose any penalty or limitation on Indemnitee without Indemnitee's
written consent.

                  f. CHANGE IN CONTROL. If there is a Change in Control (other
than a Change in Control which has been approved by a majority of the Company's
Board of Directors who were directors immediately prior to such Change in
Control), then with respect to all matters thereafter arising concerning the
rights of Indemnitee to indemnification and advances under this Agreement or
otherwise, the Company shall seek legal advice only from Independent Counsel
selected by Indemnitee and approved by the Company, which approval shall not be
unreasonably withheld. Such Independent Counsel, among other things, shall
render its written opinion to the Company and Indemnitee as to whether and to
what extent Indemnitee would be permitted to be

                                      -6-
<PAGE>

indemnified under applicable law. The Company shall pay the reasonable fees and
expenses of such Independent Counsel.

         4. NONEXCLUSIVITY. The indemnification provided by this Agreement is
not exclusive of or inconsistent with any rights to which Indemnitee may be
entitled under the Company's Certificate of Incorporation or Bylaws, any other
agreement, any vote of stockholders or directors, the DGCL, or otherwise, both
as to action in Indemnitee's official capacity and otherwise. If and to the
extent that a change in the DGCL (whether by statute or judicial decision)
permits greater indemnification by agreement than would be afforded currently
under the Company's Certificate of Incorporation or Bylaws or under this
Agreement, it is the intent of the parties hereto that Indemnitee shall enjoy by
this Agreement the greater benefits so afforded by such change.

         5. PARTIAL INDEMNIFICATION. If Indemnitee is entitled to
indemnification by the Company for some or a portion of Expenses or Liabilities
but not for the total amount, the Company shall nevertheless indemnify
Indemnitee for the portion of such Expenses and Liabilities to which Indemnitee
is entitled to be indemnified. Moreover, notwithstanding any other provision of
this Agreement, to the extent that Indemnitee has been successful on the merits
or otherwise in defense of any Proceeding or in defense of any claim, issue or
matter therein, including dismissal without prejudice, Indemnitee shall be
indemnified against all Expenses incurred by Indemnitee in connection therewith.

         6. LIABILITY INSURANCE. To the extent the Company maintains an
insurance policy or policies providing directors' and officers' liability
insurance, Indemnitee shall be covered by such policy or policies, in accordance
with its or their terms, to the maximum extent of the coverage available for any
Company director or officer, as the case may be. If Indemnitee serves as a
fiduciary of any employee benefit plan of the Company or any of its subsidiary
or affiliated corporations, then to the extent that the Company maintains an
insurance policy or policies providing fiduciaries' liability insurance,
Indemnitee shall be covered by such policy or policies in accordance with its or
their terms, to the maximum extent of the coverage available for any fiduciary.
In the event of a Potential Change in Control, the Company shall maintain in
force any and all insurance policies then maintained by the Company providing
directors' and officers' liability insurance or fiduciaries' liability
insurance, in respect of Indemnitee, for a period of six years thereafter. Upon
notice to the Company, either from Indemnitee or from any other source, of the
commencement or threat of commencement of any Proceeding or matter which may
give rise to a claim for indemnification of Indemnitee and which may be covered
by any insurance policy maintained by the Company, the Company shall promptly
give notice to the insurer in accordance with the procedures prescribed by such
policy and shall thereafter take all necessary or appropriate action to cause
such insurer to pay, to or on behalf of Indemnitee all Liabilities and Expenses
payable under such policy with respect to such Proceeding or matter. The Company
shall indemnify Indemnitee for Expenses incurred by Indemnitee in connection
with any successful action brought by Indemnitee for recovery under any
insurance policy referred to in this Section 6 and shall advance to Indemnitee
the Expenses of such action in the manner provided in Section 3(c) above.

                                      -7-
<PAGE>

         7. OTHER SOURCES. Indemnitee shall not be required to exercise any
rights Indemnitee may have against any other parties (for example, under an
insurance policy purchased by Indemnitee, the Company or any other person or
entity) before Indemnitee exercises or enforces Indemnitee's rights under this
Agreement. However, to the extent the Company actually indemnifies Indemnitee or
advances Indemnitee funds in respect of Expenses, the Company shall be entitled
to enforce any such rights which Indemnitee may have against third parties.
Indemnitee shall assist the Company in enforcing those rights if it pays
Indemnitee's costs and expenses of doing so. If Indemnitee is actually
indemnified or advanced Expenses by any such third party, then, for so long as
Indemnitee is not required to disgorge the amounts so received, to that extent
the Company shall be relieved of its obligation to indemnify Indemnitee or to
advance Expenses.

         8. CERTAIN RELATIONSHIPS. The obligations and rights created under this
Agreement shall not be affected by any amendment to the Company's Certificate of
Incorporation or Bylaws or any other agreement or instrument to which Indemnitee
is not a party, and shall not diminish any other rights which Indemnitee now or
in the future has against the Company or any other person or entity.

         9. SEVERABILITY. If any provision of this Agreement is determined to be
unenforceable for any reason, it shall be adjusted rather than voided, if
possible, in order to achieve the intent of the Company and Indemnitee. In any
event, the remaining provisions of this Agreement shall remain enforceable to
the maximum extent possible.

         10. CONTRIBUTION. If the indemnification provided in Section 2 of this
Agreement is unavailable, then, in respect of any Proceeding in which the
Company is jointly liable with Indemnitee (or would be if joined in the
Proceeding), the Company shall contribute to the amount of Expenses and
Liabilities as appropriate to reflect: (i) the relative benefits received by the
Company, on the one hand, and Indemnitee, on the other hand, from the
transaction from which the Proceeding arose, and (ii) the relative fault of the
Company, on the one hand, and of Indemnitee, on the other, in connection with
the events which resulted in such Expenses and Liabilities, as well as any other
relevant equitable considerations. The relative fault of the Company, on the one
hand, and of Indemnitee, on the other, shall be determined by reference to,
among other things, the parties' relative intent, knowledge, access to
information and opportunity to correct or prevent the circumstances resulting in
such Expenses and Liabilities. The Company agrees that it would not be just and
equitable if contribution pursuant to this Section 10 were determined by pro
rata allocation or any other method of allocation which does not take account of
the equitable considerations described in this Section 10.

         11. GOVERNING LAW. This Agreement shall be governed by and construed
and enforced in accordance with the laws of the State of Delaware applicable to
contracts made and to be performed in such state without giving effect to the
principles of conflicts of laws. This Agreement is intended to be an agreement
of the type contemplated by Section 145(f) of the DGCL.

                                      -8-
<PAGE>

         12. NOTICES. All notices and other communications under this Agreement
shall be in writing and shall be given by personal or courier delivery,
confirmed facsimile or telex transmission or first class mail, and shall be
deemed to have been duly given upon receipt if personally delivered or delivered
by courier, on the date of transmission if transmitted by facsimile or telex, or
three days after mailing if mailed, to the addresses set forth below:

                  If to Indemnitee:

                  ------------------
                  ------------------
                  ------------------
                  ------------------

                  If to the Company:

                  DoubleTwist, Inc.
                  1999 Harrison Street, Suite 1100
                  Oakland, California 94612
                  Attn:  President

or to such other address as either party may designate by notice to the other
from time to time.

         13. COUNTERPARTS. This Agreement may be executed in one or more
counterparts, each of which shall constitute an original.

         14. SUCCESSORS AND ASSIGNS. This Agreement shall be binding upon the
Company and its successors and assigns, and shall inure to the benefit of
Indemnitee and Indemnitee's spouse, estate, heirs, executors, administrators,
personal or legal representatives and assigns. The Company shall require any
successor corporation (whether by merger, consolidation, or otherwise) by
written agreement in form and substance satisfactory to Indemnitee, expressly to
assume and agree to perform this Agreement in the same manner and to the same
extent that the Company would be required to perform if no such succession had
taken place.

         15. AMENDMENT AND WAIVER. This Agreement may not be amended except by a
writing executed by both the Company and Indemnitee. No waiver of any provision
of this Agreement shall be effective unless in writing and signed by the party
to be charged therewith. A waiver of, or a failure to insist on, complete
compliance with any provision of this Agreement shall not be construed as a
waiver of a subsequent or different non-compliance, breach or default of that or
any other provision of this Agreement.

         16. ACKNOWLEDGMENT. The Company expressly acknowledges that it has
entered into this Agreement and assumed the obligations imposed on the Company
under this Agreement in order to induce Indemnitee to serve or to continue to
serve as a director or officer and acknowledges that Indemnitee is relying on
this Agreement in serving or continuing to serve in such capacity. The Company
further agrees to stipulate in any court proceeding that the Company is bound by
all of the provisions of this Agreement.

                                      -9-
<PAGE>

         17. PERIOD OF LIMITATIONS. No legal action shall be brought and no
cause of action shall be asserted by or in the right of the Company against
Indemnitee, estate, heirs, executors, administrators or personal or legal
representatives after the expiration of two years from the date of accrual of
such cause of action, and any claim or cause of action of the Company shall be
extinguished and deemed released unless asserted by the timely filing of a legal
action within such two-year period; provided, however, that if any shorter
period of limitations is otherwise applicable to any such cause of action, such
shorter period shall govern.

         18. DURATION OF AGREEMENT. This Agreement shall continue in effect for
so long as Indemnitee is subject to any possible Proceeding, regardless of
whether Indemnitee continues to serve as an Agent.

         19. ENTIRE AGREEMENT. This document contains the final, complete and
exclusive statement of the agreement between the Company and Indemnitee with
respect to the subject matter of this Agreement and supersedes any prior or
contemporaneous understandings, agreements, communications, correspondence or
representations by or between the parties, whether written or oral, relating to
the subject matter of this Agreement.

                                      -10-
<PAGE>

                  IN WITNESS WHEREOF, the parties hereto have executed this
Agreement as of the date set forth in its first paragraph.

                                          DOUBLETWIST, INC.

                                          By:
                                              ---------------------------------
                                          Name:
                                               --------------------------------
                                          Title:
                                                 ------------------------------

                                          -------------------------------------
                                          [Name], Indemnitee

                                      -11-

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