Document:

Amendment to Letter Agreement between the Company and Leanne M. Kelly

 Exhibit 10.2 
 CONFIDENTIAL AND PRIVILEDGED 
 May 8, 2008 
 Leanne Kelly 
 107 A’ja Way 
 Warminster, PA 18974 
 Dear Leanne: 
 As discussed with
you, Genaera proposes to amend your letter of employment, dated November 22, 2002, as amended. The following paragraph is hereby added: 
 “If
Genaera terminates your employment without cause (“cause” is defined in Genaera’s 2004 Stock Based Incentive Compensation Plan) you will receive (a) your monthly base salary at the highest rate in effect at any time during your
employment for twelve (12) months following your termination date; and (b) if you are eligible to participate and elect to purchase COBRA benefits continuation, Genaera will continue to pay the applicable premiums for a period equal to
that for which you are receiving severance payments. As conditions of receiving the severance pay described in this paragraph, you must: (a) sign a general release, including a non-disparagement clause, in a form acceptable to Genaera;
(b) not be in breach of any agreement executed with Genaera as part of your employment, including, the Company’s Proprietary Information Agreement (includes Non-Solicitation Clause), Code of Business Conduct and Ethics Policy, Statement on
Insider Information and Insider Trading, Conflict of Interest Policy, Sexual Harassment Policy and the Drug Free Workplace Policy; (c) keep the existence of these severance terms and your participation in the Genaera Severance Pay Program
confidential from all persons other than executive officers of Genaera, your immediate family members, your attorney, and your accountant, or other financial advisor; and (d) not, during the period that you receive payments under this
paragraph, directly or indirectly own, manage, control, participate in, consult with, render services for, or in any manner engage in any business directly competing with the businesses of Genaera or its affiliates, in any country where Genaera or
its affiliates conducts business (provided, however, that passive investments amounting to no more than three percent of the voting equity of a business shall not be prohibited). The severance payment hereunder shall be subject to the terms of the
Genaera Corporation Change of Control Severance Pay Program, provided you are an Eligible Employee under that program.” 
 Except as amended above, all
other terms and conditions of your employment shall remain in full force and effect. 
 Please indicate your acceptance of this amendment by your signature
below and return to Human Resources by May 15, 2008. 
  

	
	 /s/ John L. Armstrong, Jr.

	John L. Armstrong, Jr.
	President and Chief Executive Officer

  

			
	Accepted:	 	 /s/ Leanne M. Kelly

	Date:	 	May 8, 2008Amendment to Letter Agreement between the Company and John L. Armstrong, Jr.

 Exhibit 10.3 
 GENAERA CORPORATION 
 5110 Campus Drive 
 Plymouth Meeting, PA 19462 
 May 12, 2008 
 John L. Armstrong, Jr. 
 8 Amberfield Lane 
 Hockessin Chase 
 Hockessin, DE 19707 
 Dear Jack: 
 For and in consideration of the mutual promises contained herein
and other good and valuable consideration and intending to be legally bound, we have agreed to amend in its entirety the second paragraph of your letter agreement dated October 21, 2003, as amended by letter agreement dated November 29,
2005 and by letter agreement dated July 6, 2006 and by letter agreement dated November 29, 2007, between you and Genaera Corporation as follows: 
 If (i) your employment is terminated without “Cause,” as defined in Section 2.4 of the Genaera Corporation 2004 Stock Based Incentive Compensation Plan, except that clause (iv) of such Section
shall not apply to the definition of “Cause” as used in this letter agreement, or (ii) you terminate your employment at any time with Good Reason (as defined below), (a) you will receive your monthly base salary at the highest
rate in effect during your employment for twelve (12) months following the date of termination, (b) all of your outstanding unvested options to purchase, or awards to acquire, securities of Genaera Corporation shall vest as of the date of
termination and (c) all of your outstanding options to purchase, or awards to acquire, securities of Genaera Corporation shall remain exercisable for the shorter of five (5) years following the date of termination or the original term of
such option to purchase, or award to acquire, securities of Genaera Corporation. 
 All the terms and conditions of this letter agreement shall be binding
upon and inure to the benefit and be enforceable by the respective heirs, representative heirs, representative, successors (including any successor as a result of a merger or similar reorganization) and assigns of the parties hereto, except that
your duties and responsibilities hereunder are of a personal nature and shall not be assignable in whole or in part by you. All terms of the letter agreement dated October 21, 2003, as amended by letter agreement dated November 29, 2005
and by letter agreement dated July 6, 2006 and by letter agreement dated November 29, 2007, between you and Genaera Corporation not amended by this letter agreement shall remain in full force and effect. 

 Please indicate your agreement with the terms of this letter agreement by your signature below. 
 Sincerely, 
  

	
	 /s/ R. Frank Ecock

	R. Frank Ecock
	Chair, Compensation Committee
	
	Agreed to and Accepted:
	
	 /s/ John L. Armstrong, Jr.

	John L. Armstrong, Jr.Amendment to Letter Agreement between the Company and Michael J. Gast, M.D., Ph.

 Exhibit 10.4 
 CONFIDENTIAL AND PRIVILEDGED 
 May 8, 2008 
 Michael Gast 
 111 Augusta Drive 
 West Chester, PA 19382 
 Dear Michael: 
 As discussed
with you, Genaera proposes to amend your letter of employment, dated March 9, 2006, as amended. The following paragraph hereby replaces the third paragraph: 
 “If Genaera terminates your employment without cause (“cause” is defined in Genaera’s 2004 Stock Based Incentive Compensation Plan) you will receive (a) your monthly base salary at the highest rate in effect at any
time during your employment for twelve (12) months following your termination date; and (b) if you are eligible to participate and elect to purchase COBRA benefits continuation, Genaera will continue to pay the applicable premiums for a
period equal to that for which you are receiving severance payments. As conditions of receiving the severance pay described in this paragraph, you must: (a) sign a general release, including a non-disparagement clause, in a form acceptable to
Genaera; (b) not be in breach of any agreement executed with Genaera as part of your employment, including, the Company’s Proprietary Information Agreement (includes Non-Solicitation Clause), Code of Business Conduct and Ethics Policy,
Statement on Insider Information and Insider Trading, Conflict of Interest Policy, Sexual Harassment Policy and the Drug Free Workplace Policy; (c) keep the existence of these severance terms and your participation in the Genaera Severance Pay
Program confidential from all persons other than executive officers of Genaera, your immediate family members, your attorney, and your accountant, or other financial advisor; and (d) not, during the period that you receive payments under this
paragraph, directly or indirectly own, manage, control, participate in, consult with, render services for, or in any manner engage in any business directly competing with the businesses of Genaera or its affiliates, in any country where Genaera or
its affiliates conducts business (provided, however, that passive investments amounting to no more than three percent of the voting equity of a business shall not be prohibited). The severance payment hereunder shall be subject to the terms of the
Genaera Corporation Change of Control Severance Pay Program, provided you are an Eligible Employee under that program.” 
 Except as amended above, all
other terms and conditions of your employment shall remain in full force and effect. 
 Please indicate your acceptance of this amendment by your signature
below and return to Human Resources by May 15, 2008. 
  

			
	 /s/ John L. Armstrong, Jr.

	John L. Armstrong, Jr.
	President and Chief Executive Officer

  

			
	Accepted:	 	 /s/ Michael J. Gast, M.D., Ph.D.

 Date: May 12, 2008Amendment to the Agreement in the Event of a Change in Control

 Exhibit 10.5 
 May 8, 2008 
 Michael Gast 
 111 Augusta Drive

 West Chester, PA 19382 
  

	 	Re:	Amendment to Agreement in the Event of a Change of Control of Genaera Corporation  

 Dear Michael: 
 Paragraph 2 of the Change of Control Agreement, dated March 9, 2006, is hereby amended
in its entirety to read as follows: 
 2. Payments Upon a Covered Termination. If a Covered Termination occurs, then the Company will,
on or before your last day as an employee of the Company, pay to you, in lieu of any other rights to cash compensation other than the payment of your salary for services performed before the date of termination, as a severance benefit, a lump sum
cash payment equal to one times your total base salary plus bonus compensation from the Company for the calendar year in which the sum of such salary and bonus compensation earned by you was the highest at any time during the term of this Agreement.

 Except as amended above, all other terms and conditions of your employment shall remain in full force and effect. 
 Please indicate your acceptance of this amendment by your signature below and return to Human Resources by May 15, 2008. 
 Sincerely, 
  

			
	 /s/ John L. Armstrong, Jr.

	John L. Armstrong, Jr.
	President and Chief Executive Officer

  

			
	Accepted:	 	 /s/ Michael J. Gast, M.D., Ph.D.

 Date: May 12, 2008Amendment to the Agreement in the Event of a Change in Control

 Exhibit 10.6 
 May 8, 2008 
 Henry Wolfe 
 9 Revere Lane

 Glenmoore, PA 19343 
  

	 	Re:	Amendment to Agreement in the Event of a Change of Control of Genaera Corporation  

 Dear Henry: 
 Paragraph 2 of the Change of Control Agreement, dated March 3, 2008, is hereby amended in
its entirety to read as follows: 
 2. Payments Upon a Covered Termination. If a Covered Termination occurs, then the Company will, on
or before your last day as an employee of the Company, pay to you, in lieu of any other rights to cash compensation other than the payment of your salary for services performed before the date of termination, as a severance benefit, a lump sum cash
payment equal to one times your total base salary plus bonus compensation from the Company for the calendar year in which the sum of such salary and bonus compensation earned by you was the highest at any time during the term of your employment with
the Company. 
 Except as amended above, all other terms and conditions of your employment shall remain in full force and effect. 

Please indicate your acceptance of this amendment by your signature below and return to Human Resources by May 15, 2008. 
 Sincerely, 
  

			
	 /s/ John L. Armstrong, Jr.

	John L. Armstrong, Jr.
	President and Chief Executive Officer

  

			
	Accepted:	 	 /s/ Henry R. Wolfe, Ph.D.

 Date: May 12, 2008

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