Document:

EXECUTIVE EMPLOYMENT AGREEMENT, DATED AS OF DECEMBER 12, 2001

 EXHIBIT 4.10 
  

			
	Adherex Technologies Inc.	  	Personal and Confidential

  
 December 12, 2001 
  
 Dr. Robin J. Norris, MD 
 2966 Castle Peak Avenue 
 Superior, CO 
 80027 
 Dear Robin: 
  
 Re:     Offer of Employment 
  
 Further to our discussions, this will confirm an offer of employment to you as the Executive Vice President of Research and Development and Chief Operating Officer
with Adherex Technologies Inc., conditional on your meeting Canadian immigration requirements. This appointment will commence on January 2, 2002 under the following terms and conditions: 
  

	1.	Remuneration 

  
 You will be paid an annual base salary of Cdn $225,000 less all applicable statutory deductions. 
  

	2.	Equity Participation 

  
 As a member of the Executive Management Team, and reflective of your position as Chief Operating Officer, you will receive 600,000 share purchase options,
vesting in amounts of 200,000 shares each of January 1, 2003, January 1, 2004 and January 1, 2005. These options will have a seven year term and an exercise price of Cdn $.33 per share. 
  

	3.	Relocation and Temporary Accommodation 

  

	 	a.	Relocation Allowance. You will be provided reasonable relocation expenses and moving costs. This will also include six trips to Colorado to facilitate transition issues.

  

	 	b.	Temporary Accommodation Allowance. You will be provided with three months of temporary accommodation in a furnished apartment and other reasonable expenses in the City of Ottawa
while seeking a permanent residence. 

  

	4.	Term 

  

	 	a.	You shall be appointed a full-time employee of Adherex Technologies Inc. on an indeterminate basis, subject to earlier termination as provided hereafter. 

 

	 	b.	In the event that you wish to resign your position, you must provide three months notice of resignation in writing to the Chief Executive Officer. This notice may be reduced by
mutual agreement. 

  

	5.	Group Health and Benefits 

  
 As a member of our firm you will participate in our group benefit plan coverage involving life insurance, hospitalization, major medical, dental,
disability and other benefits of Adherex Technologies Inc. as defined in our Benefit Booklet. Costs of the benefits, other than long term disability, are paid for by Adherex. 
  

	6.	Vacation and Statutory Holidays 

  
 You are eligible for vacation in accordance with our policy. On joining our firm, you will begin accruing a vacation entitlement equivalent to four weeks
per annun. In addition, you will be entitled to be paid for all public holidays in accordance with the provisions of the Employment Standards Act of Ontario and company policy. 
  

	7.	Confidential Information 

  
 You will be required to sign the Adherex Confidentiality and Intellectual Property Agreement as a condition of your employment. A copy of this Agreement
is attached. 
  

	8.	Conflict of Interest 

  
 You shall be subject to conflict of interest requirements and shall be responsible to recognize and to avoid circumstances that may give rise to or give
the appearance of a conflict of interest situation. 
  

	9.	Termination 

  

	 	a.	Termination Without Cause 

  
 Your employment may be terminated in the absence of cause at any time and for any reason upon the provision of 1 month of pay, at your regular rate of pay
within the first three months of employment; provision of 6 months of pay, at your regular rate within 3 to 12 months of employment; and 1 year of pay, at your regular rate of pay after the first year of employment, in lieu of notice and severance
pay. 
  

	 	b.	Termination for Cause 

  
 Your employment may be terminated at any time and for any reason for cause without notice or payment in lieu of notice or severance pay, except payment of
wages and vacation pay earned to the date of termination. 
  
 If the contents of
this letter are acceptable to you, please confirm by signing the Acceptance of Offer and return to me. 
  
 Robin, I am very pleased to offer you the position of Executive Vice President Research and Development and Chief Operating Office, and on behalf of the other members of our team, welcome you to Adherex Technologies
Inc. 
  

			
	 Sincerely,

	
	 ADHEREX TECHNOLOGIES INC

		
	By:	 	 /s/ John Brooks

	 	 	 John Brooks

	 	 	 Chief Executive Officer

  

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 ACCEPTANCE OF EMPLOYMENT OFFER 
  
 I hereby fully accept the Offer of Employment extended to me on January 2, 2002 to join Adherex Technologies Inc., in Ottawa, as their
Executive Vice President of Research and Development and Chief Operating Officer, and agree to all of the terms and conditions as stated therein. 
  

									
					
	By:	 	 /s/ Robin J. Norris
	 	 	 	 Date:
	 	 December 18, 2001

	 	 	 Robin J. Norris
	 	 	 	 	 	 

  

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 CONFIDENTIALTY & INTELLECTUAL PROPERTY AGREEMENT 
  
 THIS AGREEMENT dated the 18th day of December, 2001 is made between Adherex
Technologies Inc. (the “Company”) and the undersigned employee (“Employee”). 
  
 We agree that it may be necessary for the Company to disclose to you from time to time certain confidential and proprietary information concerning the
products and processes and technology developed by Company and/or affiliates or subsidiaries which the Company wishes to protect along with its trade secrets, technical expertise, business knowledge, procedures and systems and all other confidential
and proprietary information, together with proprietary and other information of a confidential nature provided by third parties all of which is not generally available to the public, the unauthorized disclosure of which would cause irreparable harm
to the Company. 
  
 In consideration of my employment by the
Company, the undersigned and the Company agree as follows: 
  

	1.	For the purposes of this Agreement, “Information” shall include, without limitation, all unpublished know-how, technical data, techniques, records, formulae, process,
designs, sketches, photographs, plans, drawings, specifications, samples, reports, studies, findings, inventions and ideas whether patentable or not, whether they be trade secrets or not and whether they be in written, graphic or oral form, that are
now or hereafter owned or acquired by Company, all of which are of a confidential and/or proprietary nature concerning the development, testing, production and marketing of and consulting in the area of products and processes and technology
developed by Company and/or its affiliates or subsidiaries. 

  

	2.	The Employee agrees to hold in trust and confidence all Information and to use and communicate any Information only in the performance of his work for the Company to such authorized
employees, subcontractors and others as are required by their duties to have knowledge thereof or for such other purposes and to such persons as are authorized by the Company in writing. 

  

	3.	Any Information which is communicated to any person shall be stamped with the words “PROTECTED” or “CONFIDENTIAL” or other such identifying mark prior to its
disclosure to such person. 

  

	4.	All improvements, inventions, know-how and discoveries, all Information and technology, and all patents arising out of or relating to the Information whether developed by the
Employee or not during the term of the Employee’s employment are the exclusive property of Company. The Company alone shall have the right to apply for, prosecute and obtain patents, copyrights, trademarks or industrial design protection in any
or all countries of the world in respect of any and all such improvements, inventions, know-how and discoveries and the Employee agrees to disclose, deliver and assign to the Company all such improvements, inventions, know-how and discoveries
whether patentable or not and agrees at any time to execute when requested any, applications, transfers, assignments and other documents as necessary for the purpose of confirming the Company’s title to any such improvements, inventions,
know-how and discoveries, or for applying for prosecution and obtaining patents in any country with respect thereto. The Employee agrees to cooperate and assist fully in the prosecution of any such application. Any copyrightable materials generated
or developed by the Employee while employed by the Company, including but not limited to, computer programs and related documentation belonging to the Company and the Employee hereby assigns to the Company all interest and ownership in such
copyright as and when created. 

  

	5.	The Employee will notify the Company of any default that comes to the Employee’s attention and agrees to indemnify the Company for any costs, losses or damages suffered as a
result for the Employee’s failure to comply with the Agreement. As well, the Employee acknowledges that a failure to comply with the terms of this Agreement constitute grounds for dismissal with cause without notice. 

 

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	6.	The Employee will devote his full working time and attention to his employment. The Employee will not, during the term of that employment, perform work or services for a material
competitor of the Company. The Employee will not during employment with the Company compete directly or indirectly with it. The obligations of confidentially and non-disclosure contained in this Agreement will continue in effect notwithstanding
termination of employment and the Employee must continue to observe these obligations when seeking new employment. 

  

	7.	The Employee will immediately on demand return to the Company any Information in his possession and during the term of employment will allow the Company to inspect any documents or
work produced relating to the Information which are in the possession or control of the Employee. The Employee will not copy the information. On termination of his employment, all Information will be immediately returned to the Company.

  

	8.	The Employee hereby advises the Company that except to the extent of those agreements listed on Schedule “A” attached, he is not bound by any other confidentially or
disclosure agreements and agrees that he will not become a party to any such agreement with others during his employment. The Employee further advises the Company that there are no patents, patent applications or other inventions made by the
Employee prior to his employment with the Company except those specifically listed in Schedule “B”. If no Schedules are attached to this Agreement, then there are no agreements or patents outstanding. 

  

	9.	We agree that this Agreement is to be interpreted and governed by the laws of the Province of Ontario. For ease of interpretation, this Agreement is to be read with all changes in
gender and number as the circumstances require and the Agreement is binding upon and available to the benefit of both parties, their personal representatives, successors, affiliates, subsidiaries and assigns. Any notice under this Agreement should
be delivered to the Company’s head office and the Employee at his home address. 

  

	10.	Because the nature of the information is such that disclosure cannot be adequately remedied by damages, the parties agree that in addition to any other remedies available injunctive
relief may be an appropriate remedy to prevent or restrict any disclosure or further disclosure. A failure by the Company to enforce any provision of the Agreement does not constitute a waiver of any of its rights and does not release the Employee
of any responsibility for performance under the Agreement. 

  

	11.	The Company agrees that all the obligations of confidentiality and non-disclosure terminate when the Employee can establish with documentary proof that all the Information:

  

	 	(a)	was in the public domain at the time of the disclosure to the Employee by the Company, 

  

	 	(b)	entered the public domain through no fault of the Employee, 

  

	 	(c)	was in the Employee’s possession free of any obligation of confidentiality before disclosure by the Company to the Employee, or 

  

	 	(d)	was disclosed to Employee in good faith by a third party which has the right to make such disclosure, 

  
 provided that the Employee notifies the Company in writing within 10 days of receipt of the Information where the exemptions
under (c) and (d) apply. 
  

	12.	Those parts of this Agreement relating to the disclosure of Information shall continue in full force and effect after the termination of the employment of the Employee and shall
cease to have full force and effect only when and in respect of such Information as becomes part of the public domain. 

  

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	13.	The various sections of this Agreement are severable and the invalidity of one does not affect the enforceability of the other provisions of this Agreement 

 

	14.	Toutes les parties ont exigé que cet Accord soit rédigé en anglais. 

  
 All parties have requested that this Agreement be drawn up in English. 
  
 IN WITNESS WHEREOF the parties have executed this agreement on the day and
year first written above. 
  

									
	 	 	 	 	 ADHEREX TECHNOLOGIES INC.

					
	 	 	 	 	 	 	Per:	 	 /s/ John Brooks

	 	 	 	 	 	 	 	 	 John Brooks

	 	 	 	 	 	 	 	 	 Chief Executive Officer

					
	Witness	 	 /s/
	 	 	 	 	 	 /s/ Robin Norris

	 	 	 	 	 	 	 	 	 Robin Norris

  

 6EXECUTIVE EMPLOYMENT AGREEMENT, DATED AS OF JANUARY 27, 2003

 EXHIBIT 4.11 
  
 Adherex Technologies Inc 
  
 D. Scott Murray 
 37 Fielding Avenue 
 Toronto, ON 
 M4J IR4 
  
 Dear Mr. Murray, 
  
 We are pleased to offer you the position of General Counsel and Corporate Secretary at Adherex Technologies, Inc. 
  
 Reporting to John Brooks, Chief Executive Officer, you will be responsible for legal and
regulatory filing requirements, corporate compliance for securities related matters, facilitating intellectual property development, maintenance of corporate records and other corporate secretary duties, and for providing general legal counsel and
services as required. 
  
 In the corporate compliance aspect of the position,
specific responsibilities are expected to include ensuring regulatory compliance with all securities matters; playing a significant role in corporate fundraising activities; participating in presenting strategic, business and financial plans; and
managing relationships with senior management, outside auditors, Board of Directors, external counsel, and financial institutions. In this role you may also lead the financial review aspects of due diligence analysis in conjunction with the review
of new business acquisitions, divestitures, and downsizing initiatives as needed. Additionally you will fulfill the role of Adherex Corporate Secretary. 
  
 In the area concerning intellectual property, examples of specific responsibilities include advising on the considerations related to the protection and dissemination of
intellectual property; representing the organization in all phases of intellectual property activities, including opportunities for licensing and research collaboration; coordinating the workflow of patent lawyers in filing patent applications,
dealing with inventors, and assisting with litigation work. 
  
 As General
Counsel, you will be responsible for a variety of corporate legal tasks such as assisting the negotiation of corporate transactions including licenses and material transfer agreements; analyzing contracts, product acquisition agreements, and
commercial leases from other firms for conformity and the negotiation of optimal terms; identifying risk exposure; advising executive management on contractual obligations and issues; establishing and maintaining document control management
procedures; keeping current on legislative issues, statutes, decisions, and ordinances of judicial bodies; examining legal data to determine advisability of defending or prosecuting lawsuit; providing legal guidance to staff and acting as agent of
the corporation in various business transactions. 
  
 Over time, responsibilities
and/or reporting relationships may be added or changed, as business requires. 
  
 We offer an annual salary of C$150,000. You will become eligible for company-sponsored benefits, including life insurance, supplemental medical/dental coverage and three weeks paid vacation per year. In addition, you will receive paid time
off during our holiday shutdown period between Christmas and New Years. As a member of the Executive Management Team, and reflective of your position as General Counsel and Corporate Secretary, you will qualify for participation in the Adherex
Technologies Stock Option Plan, as administered and granted by the Board of Directors. Our recommendation to the board will be for 150,000 share options vesting equally over a three-year period, in accordance with the Adherex Stock Option Plan.

  
 You will be reimbursed up to C$10,000 to cover reasonable relocation expenses
and moving costs. Reasonable relocation expenses include trips between Ottawa and Toronto to facilitate transition issues, costs related to the physical move of belongings, and temporary accommodation. Costs not outlined here must be pre-approved to
be eligible for reimbursement. Additionally, receipts must be provided for all expenses. 

 For your information, a list of our benefits programs and the appropriate qualifying dates are shown in the attached Pay
and Benefit Program Outline. As a standard employee policy, Adherex reimburses employees for periodic professional association fees or dues required to maintain professional status. As per this policy, the cost of your professional fees, both legal
and pharmacy, will be reimbursed by Adherex. Additionally, it is our understanding that you will be eligible for professional liability insurance through our standard Director and Officer Insurance program. 
  
 Within your first three months of employment, your employment may be terminated in the
absence of cause at any time and for any reason upon the provision of 3 months severance pay at your regular rate. Subsequent to completion of this period, your employment may be similarly terminated with receipt of 3 months notice and 3 months
severance pay. In the event that you wish to resign your position, you must provide one month notice of resignation in writing to the Chief Executive Officer. This notice may be reduced by mutual agreement. Termination provisions will be reviewable
as part of the annual pay review process. However, unless new termination provisions are agreed upon at such time, the termination provisions herein will remain in effect. 
  
 This offer (and the attachments to it) constitute all the terms and conditions of your employment. If there have been any discussions or
correspondence with respect to your employment, this offer supercedes such discussions or correspondence. 
  
 Your contribution to the success of Adherex is important to us. We look forward to seeing you on your first day at work, which is expected to be February 3rd, 2003. If this offer is acceptable to you, please sign
below and return one original to my office. If we do not receive a signed copy of this letter on or before January 30`”, 2003, this offer is void and withdrawn. 
  
 Please accept our congratulations on your successful candidacy for this opportunity. We look forward to working with you. 
  
 Sincerely, 
  

	
	 /s/ John Brooks

	 John Brooks, CFA

	 Chief Executive Officer

  

	
	 Agreed and accepted this 27th day of January, 2003.

	
	 /s/ Scott Murray

	 Scott Murray

  

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 Employment Offer Attachment A: Pay and Benefit Program Outline 
  
 Pay and Benefit Program Outling 
  

							
	 Employee:         Scott Murray
	 	 Job Title:         Corporate Counsel

	 Start Date:
	 	Pay Rate:	 	First Pay:	 	Pay Review Date:
	 February 1, 2003
	 	 $150,000/ Year
	 	 February 15, 2003
	 	 January 1, 2004

  
 Vacation Entitlement

  
 Vacation entitle is as follows:

  

			
	 Year 1 thru 2
	 	 Three weeks (15 days)

	 Year 3 thru 5
	 	 Four weeks (20 days)

	 Year 6 and thereafter
	 	 Four weeks (20 days)

 In the first year and the years of transition to increased vacation entitlement, vacation entitlement will be pro
rated annually. 
  
 Employee Benefit Programs 
  
 The effective dates shown assume successful completion of
your Probationary Period. 
  

							
	 	 	 	 	 Cost Sharing

	 Benefit Program

	 	 Effective Date

	 	 Employer

	 	 Employee

	 Basic Group Life Insurance
	 	 May 1, 2003
	 	 100%
	 	 
	 Basic A. D. & D Insurance
	 	 May 1, 2003
	 	 100%
	 	 
	 Long Term Disability
	 	 May 1, 2003
	 	 	 	 100%

	 Dental Insurance
	 	 May 1, 2003
	 	 100%
	 	 
	 Extended health Care Insurance
	 	 May 1, 2003
	 	 100%
	 	 
	 Stock Options
	 	 February 1, 04-05-06
	 	 	 	 

  
 Terms and conditions of
Benefit Programs are governed by the Insurer’s Master Contract and are subject to change. Where the terms of the Insurer’s Master Contract conflict with what is provided herein, the terms of the master Contract govern. 
  

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 Attachment B - Statement of Terms and Conditions of Employment 
  

	1.01.1	Eligibility for Employment 

  
 In compliance with federal legislation, new employees, if requested, and as a condition of employment, must present documentation establishing their
identity and their eligibility to legally work in Canada. A valid Social Insurance Number, landed immigrant papers, employment visa, or temporary work permit is deemed sufficient for this purpose. Failure to prove eligibility for employment in
Canada constitutes just cause for immediate dismissal, without notice or compensation in lieu of notice. 
  

	1.02	Employment Application 

  
 Any misrepresentations, falsifications, or material omissions in any data requested during the employment application process or data requested during the
hiring documentation process shall result in the exclusion of the individual from further consideration for employment or, if the person has been hired, termination of employment for cause, without notice or compensation in lieu of notice.

  

	1.03	Employment Reference Checks 

  
 Adherex Technologies Inc. checks the employment references of all final candidates for employment. Offers of employment are contingent upon obtaining
satisfactory reference checks. In order to protect an applicant’s privacy and so as not to jeopardize his or her current employment reference checks with a candidate’s current employer are not made unless the candidate’s permission is
obtained. Reference checks from current employers are requested only after a conditional offer of employment is accepted. 
  

	1.04	Probationary Period 

  
 All newly hired employees are required to serve a Probationary Period during the first three (3) months after their date of hire. Significant absences
during the Probationary Period will automatically extend the period by the length of the absence. The employee is classified as Probationary during this period and is ineligible for employee benefits during this time. 
  

	1.05	Confidentiality and Inventions Agreement 

  
 All employees are required to sign a non-disclosure agreement titled the Confidentiality and Inventions Agreement. Employees who improperly use or
disclose inventions, trade secrets and/or other confidential business information will be subject to appropriate disciplinary action, up to and including termination of employment, and possibly legal action, even if they do not actually benefit from
the disclosed information. The obligations under the Confidentiality and Inventions Agreement survive termination of employment and form part of the contract of employment between the employee and Adherex Technologies Inc. 
  

	1.06	Employees are required to observe and adhere to Adherex Technologies Inc.’s polices and practices at all times. 

  
 The conditions in this Statement of Terms and Conditions shall be outlined to each
prospective employee either during the selection process and/or when an employment offer is extended and forms part of the offer of employment. 
  

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