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Exhibit 10.5    
    

EMPLOYMENT AGREEMENT  

PARTIES  

        This Employment Agreement (this "Agreement"), dated as of the 1st day of January 2005, is entered into by and between CardioTech
International, Inc., a Massachusetts corporation having its principal place of business at 229 Andover Street, Wilmington MA 01887 (the "Company"), and Michael Szycher, Ph.D., an individual
with an address at 2 Durham Drive, Lynnfield, Massachusetts 01940 (the "Executive"). 

TERMS OF AGREEMENT  

        In consideration of this-Agreement and the continued employment of the Executive by the Company, the parties agree as follows: 

        1.    Employment.    The Company hereby employs the Executive, on a full-time basis, to act as Chief
Executive Officer of the Company and to perform such acts and duties and furnish such services to the Company in connection with and related to those positions as is customary for persons with similar
positions in like companies, and as the Board of Directors of the Company (the "Board") shall from time to time reasonably direct. The Executive shall be an officer of the Company. The Company also
agrees to use its best efforts to cause the Executive to be elected a member, and the Chairman, of the Board. The Executive hereby accepts said employment. The Executive shall use his best and most
diligent efforts to promote the interests of the Company; shall discharge his duties in a highly competent manner; and shall devote his full business time and his best business judgment, skill
and knowledge to the performance of his duties and responsibilities hereunder. The Executive shall report directly to the Board. Nothing contained herein shall preclude the Executive from devoting
incidental and insubstantial amounts of time to activities other than the business of the Company. 

        2.    Term of Employment.    The Company agrees to employ the Executive for the period commencing on the date hereof
and ending on December 31, 2007 (the "Employment Period"). Notwithstanding the foregoing, both the Executive and the Company shall have the right to terminate the Executive's employment under
this Agreement upon thirty (30) days written notice to the other party, subject to the Company's obligation to pay severance benefits under certain circumstances as provided in Sections 3.6 and
3.7 hereof. If the Executive shall remain in the employ of the Company beyond the Employment Period, in the absence of any other express agreement between the parties, this Agreement shall be deemed
to continue on a month-to-month basis (the "Extended Employment Period"). 

        3.    Compensation and Benefits; Disability.    

        3.1.    Salary.    During the Executive's employment, the company shall pay the Executive an annualized base salary of
Three Hundred and Twenty Five Thousand Dollars ($325, 000) (the "Base Salary"), payable in equal installments pursuant to the Company's customary payroll policies in force at the time of payment (but
in no event less frequently than monthly), less required payroll deductions and state and federal withholdings. The Base Salary may be adjusted from time to time in the sole discretion of the Board,
except that the Executive, if a Director, shall not be entitled to vote thereon. The Base Salary shall be reviewed annually by the Board. 

        3.2.    Bonus Payment.    During the Employment Period, the Executive may receive, in the sole discretion of the
Compensation Committee of the Board (the "Compensation Committee"), an annual bonus payment in an amount, if any, to be determined by the Compensation Committee, 

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except
that the Executive, if a member of the Compensation Committee, shall not be entitled to vote thereon. 

        3.3.    Executive Benefits.    During the Employment Period, the Executive shall receive such benefits as are
customarily provided to other officers and employees of the Company, including but not limited to the following benefits: 

        (a)    Health Insurance.    Non-contributory health insurance pursuant to a health policy or substantially
similar policy; and 

        (b)    Life Insurance.    Life insurance on the life of the Executive with an Executive-directed beneficiary in the
amount of 150% of the Base Salary. 

        3.4.    Vacation.    The Executive may take four weeks of paid vacation during each year at such times as shall be
Consistent with the Company's vacation policies and (in the Board's judgment) with the Company's vacation schedule for officers and other employees. 

        3.5.    Disability or Death.    If during the Employment Period, the Executive shall (I) become ill, disabled
or otherwise incapacitated so as to be unable to perform his usual duties (a) for a period in excess of one hundred twenty (120) consecutive days or (b) for more than one hundred
eighty (180) days in-any consecutive twelve (12) month period, or (ii) die, then the Company shall have the right to terminate this Agreement, in accordance with
applicable laws, on thirty (30) days written notice to the Executive or his estate. 

        3.6.    Severance Payment.    In the event (I) the Company terminates this Agreement without cause (i.e.,
other than pursuant to Section 3.5 or Section 4 hereof) at any time (including during the Extended Employment Period, or (ii) the Executive terminates his employment for Good
Reason following a Change in Control of the Company, or (iii) the Company fails to renew this, Agreement within- two (2) years following the occurrence of a Change in Control, the
Company shall pay the Executive a severance payment equal to the Executive's then current Base Salary multiplied by 2.99; such severance payment to be adjusted to the extent necessary to avoid such
payment being treated as an "excess parachute payment" for purposes of Section 28OG of the Internal Revenue Code of 1986. 

        "Good
Reason" shall mean, during the nine (9) month period following a Change in Control, (1) a good faith determination by the Executive that As a result of such Change in
Control he is not able to discharge his duties effectively or (2) without the Executive's express written consent, the occurrence of any of the following circumstances: (a) the
assignment to the Executive of any duties inconsistent (except in the nature of a promotion) with the position in the Company that he held immediately prior to the Change in Control or a substantial
adverse alteration in the nature or status of his position or responsibilities or the Conditions of his employment from those in effect immediately prior to the Change in Control; (b) a
reduction by the Company in the Base Salary as in effect on the date of the Change in Control; (c) the Company's requiring the Executive to be based more than twenty-five
(25) miles from the Company's offices at which he was principally employed immediately prior to the date of the Change in Control except for required travel on the Company's business to an
extent substantially consistent with his present business travel obligations; or (d) the failure by the Company to continue in effect any material compensation or benefit plan in which the
Executive participates immediately prior to the Change in Control unless an equitable arrangement (embodied in an ongoing substitute or alterative plan) has been made with respect to such plan, or the
failure by the Company to Continue the Executive's participation therein (or in such substitute or alterative plan) on a basis not materially less favorable, both in terms of the amount of benefits
provided and the level of his participation relative to other participants than existed at the time of the Change in Control. The Executive's continued employment shall not constitute consent to, or a
waiver of rights with respect to, any circumstance constituting Good Reason hereunder. 

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        For
purposes of this Agreement, a "Change in Control" shall occur or be deemed to have occurred only if any of the following events occur: (i) any "person," as such term is used
in Sections 1-3(d) and 14-(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), (other than any majority owned subsidiary thereof, the Company, any
trustee or other fiduciary holding securities under an employee benefit plan of the Company, any trustee or other fiduciary of a trust treated for federal, income tax purposes as a grantor trust of
which the Company is the grantor, or any corporation owned directly or indirectly by the Stockholders of the Company in substantially the same proportion as their ownership of stock of the Company) is
or becomes the "beneficial owner" (as defined-in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the company representing 50% or more of the
combined voting power of the Company's then outstanding securities on any matter which could come before its stockholders for approval; (ii) individuals who, as of the date hereof, constitute
the Board (the "Incumbent Board") cease for any reason to constitute at least a majority of the Board, provided that any person becoming a director subsequent to the date hereof whose election, or
nomination for election by the Company's stockholders, was approved by a vote of at least a majority of the directors then comprising the Incumbent Board (other than an election or nomination of an
individual whose initial assumption of office is in connection with an actual or threatened election contest relating to the election of the directors of the Company, as-such terms are
used in Rule 14a-11 of Regulation 14A under the Exchange Act) shall be, for purposes of this Agreement, considered as though such person were a member of the Incumbent Board;
(iii) the stockholders of the Company approve a merger or consolidation of the Company with any other corporation, other than (A) a merger or consolidation which would result in the
voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity)
more than 80% of the combined voting power of the voting securities of the Company or such surviving entity outstanding immediately after such merger or consolidation or (B) a merger or
consolidation effected to implement
a recapitalization of the Company (or similar transaction) in which no "person" (as hereinabove defined) acquires more than 50% of the combined voting power of the Company's then outstanding
securities; or (iv) the stockholders of the Company approve a plan of complete liquidation of the Company or an agreement for the sale or disposition by the Company of all or substantially all
of the Company's assets. 

        3.7.    Benefits After Termination    Except as otherwise required by law, the Executive shall not be entitled to any
employee benefits provided under Section 3.3 hereof after termination of the employment of the Executive, whether or not severance pay is being provided, except that if the Executive is
entitled to the severance payment described in Section 3.6 of this Agreement, (i) the Company shall continue in full force and effect, at its expense, the life insurance provided for in
Section 3.3(b) hereof for a period of one (1) year after termination of the Executive's employment hereunder or until the Executive becomes employed, whichever first occurs, and
(ii) during the six (6) month period following the termination of the Executive's employment, the Company shall reimburse the Executive for out-of-pocket health
insurance expenses incurred by the Executive pursuant to the Consolidated Omnibus Budget Reconciliation Act of 1986 ("COBRA"). If the Executive elects not to maintain health insurance pursuant to
COBRA, the Company is under no obligation to reimburse the Executive for his otherwise elected coverage. The Executive shall be obligated to give the Company prompt notice of his employment. 

        4.    Discharge for Cause.    The Company may discharge the Executive and terminate his employment under this
Agreement for Cause without further liability to the Company by a majority vote of the Board, except that Executive, if a Director, shall not be entitled to vote thereon. As used in this Agreement,
"Cause" shall mean any or all of the following: 

        (a)   misconduct
of the Executive during the course of his employment which is materially injurious to the Company and which is brought to the attention of the Executive
promptly after 

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discovery
by the Company, including but not limited to, theft or embezzlement from the Company, the intentional provision of services to competitors of the Company, or improper disclosure of
proprietary information, but not including any act or failure to act by the Executive that he believed in good faith to be proper conduct not adverse to his duties hereunder; 

        (b)   willful
disregard or neglect by the Executive of his duties or of the Company's interests that continues after being brought to the attention of the Executive; 

        (c)   unavailability
(except as provided in Section 3.5 hereof) of the Executive to substantially perform the duties provided for herein; 

        (d)   conviction
of a fraud or felony or any criminal offense involving dishonesty, breach of trust or moral turpitude during the Executive's employment; 

        (e)   the
Executive's breach of any of the material terms of this Agreement (including the failure of the Executive to discharge his duties in a highly competent manner) or
any of the agreements executed in connection herewith as enumerated in Section 10.1 hereof. 

        In
the event the Company exercises its right to terminate the Executive's employment under this Section 4, the Executive shall not be entitled to receive any severance pay or
other termination benefits, except as required by law. 

        5.    Termination Without Cause.    The Company may terminate this Agreement without cause, without further liability
to the Company except as set forth in Sections 3.6 and 3.7 hereof, by a majority vote of the Board. The Executive, if a Director, shall not be entitled to vote on the termination of this Agreement
without Cause. 

        6.    Expenses.    Pursuant to the Company' s customary policies in force at the time of payment, the Executive shall
be promptly reimbursed, against presentation of vouchers or receipts therefor, for all authorized expenses properly incurred by him on the Company's behalf in the performance of his duties hereunder. 

        7.    Additional Agreements.    Upon execution of this Agreement, the Executive shall execute and deliver to the
Company an Agreement Not to Compete (the "Noncompetition Agreement") and a Confidential and Proprietary Information Agreement (the "Confidential And Proprietary Information Agreement") substantially
in the forms attached hereto as Exhibits A and B. The agreements attached hereto as Exhibits A and B
shall survive the expiration of or termination of this Agreement and the termination of Executive's employment with the Company for any reason. 

        8.    Arbitration.    All disputes and claims relating to this Agreement and the rights, obligations and performance
of the parties hereto shall be settled by a single arbitrator sitting in Boston, Massachusetts under the applicable rules of the American Arbitration Association. 

        9.    Notices.    Any notice of communication given by any " party hereto to the other party or parties shall be in
writing and personally delivered, mailed by certified mail, return receipt requested, postage prepaid, or delivered by a recognized overnight carrier, to the addresses provided above. All notices
shall be deemed given when actually received. Any person entitled to receive notice (or a copy thereof) may designate in writing, by notice to the others, another address to which notices to such
person shall thereafter be sent 

        10.    Miscellaneous.    

        10.1.    Entire Agreement.    This Agreement contains the entire understanding of the parties in respect of its
subject tatter and supersedes all prior agreements and understandings between the parties with respect to such subject matter; provided, however, that nothing in this Agreement shall affect the
Executive's or the Company's obligations under the Noncompetition Agreement or the 

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Confidential
and Proprietary Information Agreement each dated May 1996, between the parties hereto. 

        10.2.    Amendment; Waiver.    This Agreement may not be amended, supplemented, canceled or discharged, except by
written instrument executed by the party affected thereby. No failure to exercise, and no delay in exercising, any right, power or privilege hereunder shall operate as a waiver thereof. No waiver of
any breach of any provision of this Agreement shall be deemed to be a waiver of any preceding or succeeding breach of the same or any other provisions. 

        10.3.    Binding Effect; Assignment.    The rights and obligations of this Agreement shall bind and inure to the
benefit of any successor of the Company by reorganization, merger or consolidation, or any assignee of all or substantially all of the Company's business and properties. The Executive's rights or
obligations under this Agreement may not be assigned by the Executive; except that the Executive's right to compensation to the earlier of the date of death, disability pursuant to Section 3.5
hereof, or termination of actual employment, shall pass to the Executive's executor or administrator. 

        10.4.    Headings.    The headings contained in this Agreement are for reference purposes only and shall not affect
the meaning or interpretation of this Agreement. 

        10.5.    Governing Law: Interpretation.    This Agreement shall be construed in accordance with and governed for all
purposes by the laws and public policy of the Commonwealth of Massachusetts applicable to contracts executed and to be wholly performed within such Commonwealth. Service of process in any dispute
shall be effective (a) upon the Company, if service is made on any officer of the Company other than the Executive; (b) upon the Executive, if served at the Executive's residence last
known to the Company with an information copy to the Executive at any other residence, or in care of a subsequent employer of which the Company may be aware. 

        10.6.    Further Assurances.    Each of the parties agrees to execute, acknowledge, deliver and perform, or cause to
be executed, acknowledged, delivered or performed, at any time, or from time to time, as the case may be, all such further acts deeds, assignments, transfers, conveyances, powers of attorney and
assurances as may be necessary or proper to carry out the provisions or intent of this Agreement. 

        10.7.    Severability.    If any one or more of the terms, provisions, covenants or restrictions of this Agreement
shall be determined by a court of competent jurisdiction to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full
force and effect, and shall in no way be affected, impaired or invalidated. If, moreover, any one or more of the provisions contained in this Agreement shall for any reason be determined by a court of
competent jurisdiction to be excessively broad as to duration, geographical scope, activity or subject, it shall be construed by limiting or reducing it so as to be enforceable to the extent
compatible with then applicable law. 

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EXECUTION  

        The parties executed this Agreement as a sealed instrument as of the date first above written, whereupon it became binding in accordance with its terms. 

	 	 	CARDIOTECH INTERNATIONAL, INC.

Compensation Committee
	

 	
 	

By:	

/s/  MICHAEL ADAMS      
 Name: Michael Adams

Title: Chairman, Compensation Committee
	

 	
 	

EXECUTIVE
	

 	
 	

By:	

/s/  MICHAEL SZYCHER, PH.D.      
 Michael Szycher, Ph.D.

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Exhibit 10.5<Page>

                                                                     Exhibit 4.1

                                           COMMON STOCK

                      Number                                             Shares

                                   COMBINATORX, INCORPORATED

                                  INCORPORATED UNDER THE LAWS
                                   OF THE STATE OF DELAWARE

                                                 CUSIP _______________
                                      SEE REVERSE SIDE FOR CERTAIN DEFINITIONS

THIS CERTIFIES THAT

IS THE OWNER OF

FULLY-PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK, PAR VALUE OF $0.001
PER SHARE OF COMBINATORX, INCORPORATED transferable on the books of the Company
by the holder hereof, in person, or by duly authorized attorney upon surrender
of this Certificate properly endorsed. The shares represented by this
Certificate are subject to the provisions of the certificate of incorporation
and by-laws of the Company as from time to time amended or restated. This
Certificate is not valid until countersigned by the Transfer Agent and
registered by the Registrar.

Witness the facsimile signatures of its duly authorized officers.

               PRESIDENT                                   TREASURER

Countersigned and Registered:

EQUISERVE TRUST COMPANY, N.A.
By:  ____________
Transfer Agent and Registrar

Authorized Signature

<Page>

                            COMBINATORX, INCORPORATED

THE RECORD HOLDER OF THIS CERTIFICATE MAY OBTAIN FROM THE SECRETARY OF THE
COMPANY, UPON REQUEST AND WITHOUT CHARGE, A FULL STATEMENT OF THE DESIGNATION,
RELATIVE RIGHTS, PREFERENCES AND LIMITATIONS OF THE SHARES OF EACH CLASS
AUTHORIZED TO BE ISSUED AND THE DESIGNATION, RELATIVE RIGHTS, PREFERENCES AND
LIMITATIONS OF EACH SERIES OF PREFERRED SHARES AUTHORIZED TO BE ISSUED SO FAR AS
THE SAME HAVE BEEN FIXED AND THE AUTHORITY OF THE BOARD OF DIRECTORS TO
DESIGNATE AND FIX THE RELATIVE RIGHTS, PREFERENCES AND LIMITATIONS OF OTHER
SERIES.

The following abbreviations, when used in the inscription on the face of this
certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

<Table>
<Caption>
<S>                                                               <C>
TEN COM - as tenants in common                                    UNIF GIFT MIN ACT - _________ Custodian _________

TEN ENT - as tenants by the entireties                                               (Custodian)           (Minor)
JT TEN  - as joint tenants with right of survivorship
                     and not as tenants in common
                                                                                   Under Uniform Gifts to Minors Act

                                                                                         ___________ (State)

Additional abbreviations may also be used though not in the above list.

For value received, ________________________________ hereby sell, assign and transfer unto

                 PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE

______________________________________________________________________________________________________________________
______________________________________________________________________________________________________________________

               (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE OF ASSIGNEE)

______________________________________________________________________________________________________________________
______________________________________________________________________________________________________________________
______________________________________________________________________________________________________________________
_____________________________________________________________________________ shares
of the stock represented by the within certificate, and do hereby irrevocably constitute and appoint
                  _____________________________________________________________________________ Attorney
                  to transfer the said stock on the books of the within named Company with full
                  power of substitution in the premises.

Dated  __________________________________________________                  X   ______________________________________

                                                                           X   ______________________________________
                                                                               NOTICE: THE SIGNATURE ON THIS ASSIGNMENT
                                                                               MUST CORRESPOND EXACTLY WITH THE NAME
                                                                               WRITTEN UPON THE FACE OF THE CERTIFICATE.

Signature(s) Guaranteed:

_________________________________________________________
THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR
INSTITUTION, AS DEFINED IN RULE 17AD-15 UNDER THE SECURITIES AND
EXCHANGE ACT OF 1934, AS AMENDED

KEEP THIS CERTIFICATE IN A SAFE PLACE. IF IT IS LOST, STOLEN, OR DESTROYED, THE
COMPANY MAY REQUIRE A BOND OF INDEMNITY AS A CONDITION TO THE ISSUANCE OF A
REPLACEMENT CERTIFICATE.
</Table>

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