Document:

<PAGE>
                                CREDIT AGREEMENT,

                          dated as of October 18, 2005

                                      among

                             DULOXETINE ROYALTY SUB,

                         DULOXETINE HOLDCO ROYALTY SUB,

       VARIOUS FINANCIAL INSTITUTIONS AND OTHER PERSONS FROM TIME TO TIME
                                 PARTIES HERETO,

                                 as the Lenders

                                       and

                      MORGAN STANLEY SENIOR FUNDING, INC.,

       as the Administrative Agent and Syndication Agent for the Lenders.

                                   ----------

                      MORGAN STANLEY SENIOR FUNDING, INC.,

                                as Lead Arranger
<PAGE>
                                    CONTENTS

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ARTICLE I DEFINITIONS AND ACCOUNTING TERMS...............................     2
   SECTION 1.1.     Defined Terms........................................     2
   SECTION 1.2.     Cross-References.....................................     2
   SECTION 1.3.     Accounting and Financial Determinations..............     2
ARTICLE II COMMITMENTS, BORROWING PROCEDURES AND NOTES...................     2
   SECTION 2.1.     Commitments..........................................     2
   SECTION 2.2.     Borrowing Procedures.................................     2
   SECTION 2.3.     Continuation and Conversion Elections................     2
   SECTION 2.4.     Funding..............................................     3
   SECTION 2.5.     Register; Notes......................................     3
ARTICLE III REPAYMENTS, PREPAYMENTS, INTEREST AND FEES...................     4
   SECTION 3.1.     Repayments and Prepayments; Application..............     4
   SECTION 3.2.     Interest Provisions..................................     5
ARTICLE IV CERTAIN LIBO RATE AND OTHER PROVISIONS........................     6
   SECTION 4.1.     LIBO Rate Lending Unlawful...........................     6
   SECTION 4.2.     Deposits Unavailable.................................     6
   SECTION 4.3.     Increased LIBO Rate Loan Costs, etc..................     6
   SECTION 4.4.     Funding Losses.......................................     7
   SECTION 4.5.     Increased Capital Costs..............................     7
   SECTION 4.6.     Taxes................................................     7
   SECTION 4.7.     Payments, Computations; Proceeds of Collateral, etc..    10
   SECTION 4.8.     Sharing of Payments..................................    10
   SECTION 4.9.     Setoff...............................................    11
ARTICLE V CONDITIONS TO LOANS............................................    11
   SECTION 5.1.     Resolutions, etc.....................................    11
   SECTION 5.2.     Closing Date Certificate.............................    12
   SECTION 5.3.     Compliance with Warranties, no Default, etc..........    12
   SECTION 5.4.     Consummation of Transaction..........................    13
   SECTION 5.5.     Delivery of Notes....................................    13
   SECTION 5.6.     Security Agreements..................................    13
   SECTION 5.7.     Filing Agent, etc....................................    14
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                                    CONTENTS

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   SECTION 5.8.     Opinions of Counsel..................................    14
   SECTION 5.9.     Intercreditor Agreement..............................    14
   SECTION 5.10.    Co-Promotion Agreement...............................    14
   SECTION 5.11.    Notice to Lilly......................................    14
   SECTION 5.12.    Borrowing Request....................................    15
   SECTION 5.13.    Hedge Agreement......................................    15
   SECTION 5.14.    Patriot Act Disclosures..............................    15
   SECTION 5.15.    Closing Fees, Expenses, etc..........................    15
   SECTION 5.16.    Satisfactory Legal Form..............................    15
ARTICLE VI REPRESENTATIONS AND WARRANTIES................................    15
   SECTION 6.1.     Representations and Warranties of Royalty Sub........    15
   SECTION 6.2.     Representations and Warranties of Royalty Sub, the
                    Pledgor and Quintiles................................    18
ARTICLE VII COVENANTS....................................................    20
   SECTION 7.1.     Affirmative Covenants................................    20
   SECTION 7.2.     Other Covenants......................................    21
   SECTION 7.3.     Covenants of Pledgor.................................    25
ARTICLE VIII EVENTS OF DEFAULT...........................................    26
   SECTION 8.1.     Listing of Events of Default.........................    26
   SECTION 8.2.     Termination of Commitments...........................    27
   SECTION 8.3.     Remedies.............................................    27
ARTICLE IX THE AGENTS....................................................    30
   SECTION 9.1.     Actions..............................................    30
   SECTION 9.2.     Funding Reliance, etc................................    31
   SECTION 9.3.     Exculpation..........................................    31
   SECTION 9.4.     Successor............................................    31
   SECTION 9.5.     Loans by MS..........................................    32
   SECTION 9.6.     Credit Decisions.....................................    32
   SECTION 9.7.     Copies, etc..........................................    32
   SECTION 9.8.     Reliance by Administrative Agents....................    33
   SECTION 9.9.     Defaults.............................................    33
ARTICLE X MISCELLANEOUS PROVISIONS.......................................    33
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<PAGE>
                                    CONTENTS

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   SECTION 10.1.    Waivers, Amendments, etc.............................    33
   SECTION 10.2.    Notices; Time........................................    34
   SECTION 10.3.    Payment of Costs and Expenses........................    35
   SECTION 10.4.    Indemnification......................................    35
   SECTION 10.5.    Survival.............................................    36
   SECTION 10.6.    Severability.........................................    36
   SECTION 10.7.    Headings.............................................    37
   SECTION 10.8.    Execution in Counterparts, Effectiveness, etc........    37
   SECTION 10.9.    Governing Law; Entire Agreement......................    37
   SECTION 10.10.   Successors and Assigns...............................    37
   SECTION 10.11.   Sale and Transfer of Loans; Participations in Loans;
                    Notes................................................    37
   SECTION 10.12.   Other Transactions...................................    39
   SECTION 10.13.   Forum Selection and Consent to Jurisdiction..........    39
   SECTION 10.14.   Waiver of Jury Trial.................................    40
   SECTION 10.15.   Immunity; Judgment Currency..........................    41
   SECTION 10.16.   Limited Recourse.....................................    41
   SECTION 10.17.   Patriot Act..........................................    42
   SECTION 10.18.   Intercreditor Provisions.............................    42
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SCHEDULE I  - Percentages; LIBOR Office; Domestic Office

ANNEX A     - Defined Terms

EXHIBIT A   - Form of Note
EXHIBIT B   - Form of Borrowing Request
EXHIBIT C   - Form of Continuation/Conversion Notice
EXHIBIT D   - Form of Closing Date Certificate
EXHIBIT E-1 - Form of Loan Security Agreement
EXHIBIT E-2 - Form of First Lien Pledge and Security Agreement
EXHIBIT F   - Form of Intercreditor Agreement
EXHIBIT G   - Form of Lender Assignment Agreement
EXHIBIT H   - Form of Confidentiality Agreement
EXHIBIT I   - Service of Process

                                      -iv-
<PAGE>
                                CREDIT AGREEMENT

     THIS CREDIT AGREEMENT, dated as of October 18, 2005, is among Duloxetine
Royalty Sub, an exempted company incorporated with limited liability under the
laws of the Cayman Islands ("Royalty Sub"), Duloxetine Holdco Royalty Sub, an
exempted company incorporated with limited liability under the laws of the
Cayman Islands (the "Pledgor"), the various financial institutions and other
Persons from time to time parties hereto (the "Lenders") and MORGAN STANLEY
SENIOR FUNDING, INC. ("MS"), as administrative agent (in such capacity, the
"Administrative Agent") and syndication agent (in such capacity, the
"Syndication Agent") for the Lenders and as the Lead Arranger. Quintiles
Transnational Corp., a North Carolina corporation ("Quintiles") is an additional
party hereto with respect only to the Sections listed above its signature
hereto.

                                   WITNESSETH:

     WHEREAS, Royalty Sub intends to acquire (the "Acquisition") certain rights
(as further defined in Annex A attached hereto, the "Royalty Sub Rights") of
Quintiles under the Duloxetine-Depression U.S. Co-Promotion Agreement, dated as
of July 18, 2002 (as amended by amendments dated as of December 1, 2003 and
August 18, 2005, and as further amended, supplemented, amended and restated or
otherwise modified from time to time as permitted under this Agreement, the
"Co-Promotion Agreement"), between Eli Lilly and Company, an Indiana corporation
("Lilly"), and Quintiles, in accordance with the terms and conditions of a
Purchase and Sale Agreement, dated as of the Closing Date (as amended,
supplemented, amended and restated or otherwise modified from time to time as
permitted under this Agreement, the "Purchase and Sale Agreement"), to be
entered into by Royalty Sub, Pledgor and Quintiles;

     WHEREAS, in order to consummate the Acquisition and to pay fees, costs and
expenses associated therewith (collectively, the "Transaction"):

          (a) Royalty Sub has requested that the Lenders provide a commitment
     pursuant to which Loans will be made, in a maximum original principal
     amount equal to $125,000,000, to Royalty Sub in a single borrowing on the
     Closing Date; and

          (b) Royalty Sub intends to issue on the Closing Date its Class A
     Duloxetine PhaRMA(SM) Second Lien 13% Notes due 2013 (the "Second Lien
     Notes") in an aggregate principal amount of $125,000,000, pursuant to the
     terms of that certain Indenture, dated as of the date hereof (as amended,
     supplemented, amended and restated or otherwise modified from time to time
     as permitted under this Agreement, the "Indenture"), by and between Royalty
     Sub as the issuer of the Second Lien Notes and U.S. Bank National
     Association, as initial trustee of the Second Lien Notes (together with any
     successor trustee thereunder, the "Trustee"); and

     WHEREAS, the Lenders are willing, on the terms and subject to the
conditions hereinafter set forth, to extend the Commitments and Loans to Royalty
Sub;

     NOW, THEREFORE, the parties hereto agree as follows.
<PAGE>
                                    ARTICLE I
                        DEFINITIONS AND ACCOUNTING TERMS

     SECTION 1.1. Defined Terms. Capitalized terms used herein and defined in
Annex A hereto shall have the meanings set forth therein, and such Annex A is
hereby incorporated herein by reference. Unless otherwise defined or the context
otherwise requires, terms for which meanings are provided in this Agreement or
in Annex A hereto shall have such meanings when used in each other Loan Document
(other than the Intercreditor Agreement, which has its own defined terms).
Capitalized terms, if any, used in any Loan Document that are not defined herein
or within the relevant Loan Document, shall have the meaning given to such terms
in Annex A to the Intercreditor Agreement.

     SECTION 1.2. Cross-References. Unless otherwise specified, references in a
Loan Document to any Article or Section are references to such Article or
Section of such Loan Document, and references in any Article, Section or
definition to any clause are references to such clause of such Article, Section
or definition.

     SECTION 1.3. Accounting and Financial Determinations. Unless otherwise
specified, all accounting terms used in each Loan Document shall be interpreted,
and all accounting determinations and computations thereunder shall be made, in
accordance with GAAP.

                                   ARTICLE II
                   COMMITMENTS, BORROWING PROCEDURES AND NOTES

     SECTION 2.1. Commitments. In a single Borrowing (which shall be a Business
Day) occurring on or prior to the Commitment Termination Date, each Lender
agrees that it will make loans (relative to such Lender, its "Loans") to Royalty
Sub equal to such Lender's Percentage of the aggregate amount of the Borrowing
of Loans requested by Royalty Sub to be made on such day. No amounts paid or
prepaid with respect to the Loans may be reborrowed.

     SECTION 2.2. Borrowing Procedures. Royalty Sub has delivered a Borrowing
Request to the Administrative Agent requesting that a Borrowing be made in the
form of LIBO Rate Loans in an amount equal to the Commitment Amount. On the
terms and subject to the conditions of this Agreement, such Borrowing shall be
made on October 18, 2005, the Business Day specified in such Borrowing Request.
On or before 11:00 a.m. on such Business Day each Lender that has a Commitment
to make the Loans being requested shall deposit with the Administrative Agent
same day funds in an amount equal to such Lender's Percentage of the requested
Borrowing. Such deposit will be made to an account which the Administrative
Agent shall specify by notice to the Lenders. The Administrative Agent shall
make such funds available to Royalty Sub by wire transfer to the accounts
Royalty Sub shall have specified in its Borrowing Request. No Lender's
obligation to make any Loan shall be affected by any other Lender's failure to
make any Loan.

     SECTION 2.3. Continuation and Conversion Elections. By delivering a
Continuation/Conversion Notice to the Administrative Agent on or before 10:00
a.m. on a Business Day, Royalty Sub may from time to time irrevocably elect, on
not less than one Business Day's notice in the case of Base Rate Loans, or three
Business Days' notice in the case

                                       -2-
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of LIBO Rate Loans, and in either case not more than five Business Days' notice,
that all Loans, or any portion of Loans in an aggregate minimum amount of
$1,000,000, and an integral multiple of $1,000,000 be, in the case of Base Rate
Loans, converted into LIBO Rate Loans or be, in the case of LIBO Rate Loans,
converted into Base Rate Loans or continued as LIBO Rate Loans (in the absence
of delivery of a Continuation/Conversion Notice with respect to any LIBO Rate
Loan at least three Business Days (but not more than five Business Days) before
the last day of the then current Interest Period with respect thereto, such LIBO
Rate Loan shall, on such last day, automatically convert to a Base Rate Loan);
provided that (x) each such conversion or continuation shall be pro rated among
the applicable outstanding Loans of all Lenders that have made such Loans, and
(y) no portion of the outstanding principal amount of any Loans may be continued
as, or be converted into, LIBO Rate Loans when any Default has occurred and is
continuing.

     SECTION 2.4. Funding. Each Lender may, if it so elects, fulfill its
obligation to make, continue or convert LIBO Rate Loans hereunder by causing one
of its foreign branches or Affiliates (or an international banking facility
created by such Lender) to convert or maintain such LIBO Rate Loan; provided
that such LIBO Rate Loan shall nonetheless be deemed to have been made and to be
held by such Lender, and the obligation of Royalty Sub to repay such LIBO Rate
Loan shall nevertheless be to such Lender for the account of such foreign
branch, Affiliate or international banking facility. In addition, Royalty Sub
hereby consents and agrees that, for purposes of any determination to be made
for purposes of Sections 4.1, 4.2, 4.3 or 4.4, it shall be conclusively assumed
that each Lender elected to fund all LIBO Rate Loans by purchasing Dollar
deposits in its LIBOR Office's interbank eurodollar market.

     SECTION 2.5. Register; Notes. (a) Royalty Sub hereby designates the
Administrative Agent to serve as Royalty Sub's agent, solely for the purpose of
this clause, to maintain a register (the "Register") on which the Administrative
Agent will record each Lender's Commitment, the Loans made by each Lender and
each repayment in respect of the principal amount of the Loans, annexed to which
the Administrative Agent shall retain a copy of each Confidentiality Agreement
delivered to the Administrative Agent, and each Lender Assignment Agreement
delivered to the Administrative Agent pursuant to Section 10.11. Failure to make
any recordation, or any error in such recordation, shall not affect any
Obligor's Obligations. The entries in the Register shall be conclusive, in the
absence of manifest error, and Royalty Sub, the Administrative Agent and the
Lenders shall treat each Person in whose name a Loan is registered (or, if
applicable, to which a Note has been issued) as the owner thereof for the
purposes of all Loan Documents, notwithstanding notice or any provision herein
to the contrary. Any assignment or transfer of a Commitment or the Loans made
pursuant hereto shall be registered in the Register only upon delivery to the
Administrative Agent of a Lender Assignment Agreement and a Confidentiality
Agreement that has been executed by the requisite parties pursuant to Section
10.11. No assignment or transfer of a Lender's Commitment or Loans shall be
effective unless such assignment or transfer shall have been recorded in the
Register by the Administrative Agent as provided in this Section.

     (b) Royalty Sub agrees that, upon the request to the Administrative Agent
by any Lender, Royalty Sub will execute and deliver to such Lender a Note
evidencing the Loans made by, and payable to the order of, such Lender in a
maximum principal amount equal to such Lender's Percentage of the Commitment
Amount. Royalty Sub hereby irrevocably authorizes

                                       -3-
<PAGE>
each Lender to make (or cause to be made) appropriate notations on the grid
attached to such Lender's Note (or on any continuation of such grid), which
notations, if made, shall evidence, inter alia, the date of, the outstanding
principal amount of, and the interest rate and Interest Period applicable to the
Loans evidenced thereby. Such notations shall, to the extent not inconsistent
with notations made by the Administrative Agent in the Register, be conclusive
and binding on each Obligor absent manifest error; provided that the failure of
any Lender to make any such notations or any error in such notations shall not
limit or otherwise affect any Obligations of any Obligor.

                                   ARTICLE III
                   REPAYMENTS, PREPAYMENTS, INTEREST AND FEES

     SECTION 3.1. Repayments and Prepayments; Application. Royalty Sub agrees
that the Loans shall be repaid and prepaid pursuant to the following terms and
in accordance with the terms of the Intercreditor Agreement.

     SECTION 3.1.1. Repayments and Prepayments. Royalty Sub shall repay in full
the unpaid principal amount of each Loan on the Stated Maturity Date. Prior
thereto, payments and prepayments of the Loans shall or may be made as set forth
below.

     (a) From time to time on any Business Day, Royalty Sub may make a voluntary
prepayment, in whole or in part, of the outstanding principal amount of any
Loans by depositing or causing to be deposited in the Repayment/Redemption
Account in immediately available funds an amount equal to the amount of such
Loans to be prepaid (including any interest payable thereon and any amounts
payable pursuant to Article IV with respect thereto); provided that (i) all such
voluntary prepayments shall require at least one but no more than five Business
Days' prior notice to the Administrative Agent; and (ii) all such voluntary
partial prepayments shall be, in the case of LIBO Rate Loans, in an aggregate
minimum amount of $1,000,000 and an integral multiple of $1,000,000 and, in the
case of Base Rate Loans, in an aggregate minimum amount of $500,000 and an
integral multiple of $100,000.

     (b) Royalty Sub shall make a mandatory repayment of the Loans on the
Payment Date immediately following the occurrence of any Change of Control Event
(the "Mandatory Repayment Date"), and the Loans and all other Obligations shall
automatically become due and payable on such Mandatory Repayment Date. On or
before the Mandatory Repayment Date, Royalty Sub shall, to the extent an amount
equal to the aggregate outstanding principal amount of the Loans and all other
Obligations as of the Mandatory Repayment Date is not then held on deposit in
the Repayment/Redemption Account, deposit or cause to be deposited in the
Repayment/Redemption Account an amount in immediately available funds equal to
the amount of such Loans and other Obligations.

Each prepayment of any Loans made pursuant to this Section shall be without
premium or penalty, except as may be required by Section 4.4.

     SECTION 3.1.2. Application. Each prepayment or repayment of the principal
of the Loans made in accordance with the terms of the Intercreditor Agreement
shall be applied, to the extent of such prepayment or repayment, first, to the
principal amount thereof being maintained

                                       -4-
<PAGE>
as Base Rate Loans, and second, subject to the terms of Section 4.4, to the
principal amount thereof being maintained as LIBO Rate Loans.

     SECTION 3.2. Interest Provisions. Interest on the outstanding principal
amount of the Loans shall accrue and be payable in accordance with the terms set
forth below and the terms of the Intercreditor Agreement.

     SECTION 3.2.1. Rates. Pursuant to an appropriately delivered Borrowing
Request or Continuation/Conversion Notice, Royalty Sub may elect that the Loans
accrue interest at a rate per annum:

          (a) on that portion maintained from time to time as a Base Rate Loan,
     equal to the sum of the Alternate Base Rate from time to time in effect
     plus the Applicable Margin; and

          (b) pursuant to a Continuation/Conversion Notice, on that portion
     maintained as a LIBO Rate Loan, during each Interest Period applicable
     thereto, equal to the sum of the LIBO Rate (Reserve Adjusted) for such
     Interest Period plus the Applicable Margin.

All LIBO Rate Loans shall bear interest from and including the first day of the
applicable Interest Period to (but not including) the last day of such Interest
Period at the interest rate determined as applicable to such LIBO Rate Loan.
Interest on Base Rate Loans shall be calculated from and including the first day
of the Borrowing of such Base Rate Loan to (but not including) the date interest
is required to be paid on such Base Rate Loan pursuant to Section 3.2.3.

     SECTION 3.2.2. Post-Default Rates. Upon the occurrence and during the
continuance of any Event of Default, the Loans and other Obligations shall bear
interest (after as well as before any judgment) at a rate that is (i) in the
case of the Loans, the rate of interest that otherwise would be applicable to
such Loans plus 2% per annum and (ii) in the case of other monetary Obligations,
the Alternate Base Rate plus 2% per annum, in each case to the extent permitted
by law.

     SECTION 3.2.3. Payment Dates. Interest accrued on each Loan shall be
payable, without duplication:

          (a) on the Stated Maturity Date;

          (b) on the date of any payment or prepayment (including a Mandatory
     Repayment Date), in whole or in part, of principal outstanding on such Loan
     on the principal amount so paid or prepaid;

          (c) with respect to Base Rate Loans, on each Payment Date occurring
     after the Effective Date;

          (d) with respect to LIBO Rate Loans, on the Payment Date falling on
     the last day of each applicable Interest Period; and

                                       -5-
<PAGE>
          (e) with respect to any Base Rate Loans converted into LIBO Rate Loans
     on a day when interest would not otherwise have been payable pursuant to
     clause (d), on the Payment Date immediately following the date of such
     conversion.

Interest accrued on Loans or other monetary Obligations after the date such
amount is due and payable (whether on the Stated Maturity Date, on a Mandatory
Repayment Date or otherwise) shall be payable upon the earlier of the Stated
Maturity Date or the immediately succeeding Payment Date.

                                   ARTICLE IV
                     CERTAIN LIBO RATE AND OTHER PROVISIONS

     SECTION 4.1. LIBO Rate Lending Unlawful. If any Lender shall determine
(which determination shall, upon notice thereof to Royalty Sub and the
Administrative Agent, be conclusive and binding on Royalty Sub) that the
introduction of or any change in or in the interpretation of any law makes it
unlawful, or any Governmental Authority asserts that it is unlawful, for such
Lender to continue any Loan as, or to convert any Loan into, a LIBO Rate Loan,
the obligations of such Lender to continue or convert any such LIBO Rate Loan
shall, upon such determination, forthwith be suspended until such Lender shall
notify the Administrative Agent that the circumstances causing such suspension
no longer exist, and all outstanding LIBO Rate Loans payable to such Lender
shall automatically convert into Base Rate Loans at the end of the then current
Interest Periods with respect thereto or sooner, if required by such law or
assertion.

     SECTION 4.2. Deposits Unavailable. If (a) the Administrative Agent shall
have determined that (i) Dollar deposits in the relevant amount and for the
relevant Interest Period are not available to it in its relevant market or (ii)
by reason of circumstances affecting its relevant market, adequate means do not
exist for ascertaining the interest rate applicable hereunder to LIBO Rate Loans
or (b) the Administrative Agent shall have received notice from the Required
Lenders that the LIBO Rate (Reserve Adjusted) determined or to be determined for
such Interest Period will not adequately and fairly reflect the cost to such
Lenders (as conclusively certified by such Lenders) of converting or maintaining
their affected Loans during such Interest Period, then, upon notice from the
Administrative Agent to Royalty Sub and the Lenders, the obligations of all
Lenders under Section 2.3 and Section 2.4 to continue any Loans as, or to
convert any Loans into, LIBO Rate Loans shall forthwith be suspended until the
Administrative Agent shall notify Royalty Sub and the Lenders that the
circumstances causing such suspension no longer exist.

     SECTION 4.3. Increased LIBO Rate Loan Costs, etc. Royalty Sub agrees to
reimburse each Lender for any increase in the cost to such Lender of, or any
reduction in the amount of any sum receivable by such Lender in respect of, such
Lender's Commitments and the making of Loans hereunder (including the continuing
or maintaining (or of its obligation to continue) any Loans as, or of converting
(or of its obligation to convert) any Loans into, LIBO Rate Loans) that arise in
connection with any change in, or the introduction, adoption, effectiveness,
interpretation, reinterpretation or phase-in after the Closing Date of, any law
or regulation, directive, guideline, decision or request (whether or not having
the force of law) of any Governmental Authority, except for such changes with
respect to increased capital costs and

                                       -6-
<PAGE>
Taxes which are governed by Sections 4.5 and 4.6, respectively. Each affected
Lender shall promptly notify the Administrative Agent and Royalty Sub in writing
of the occurrence of any such event, stating the reasons therefor and the
additional amount required fully to compensate such Lender for such increased
cost or reduced amount. Such additional amounts shall be payable by Royalty Sub
directly to such Lender upon the Payment Date immediately following such notice
(subject to the terms of the Intercreditor Agreement), and such notice shall, in
the absence of manifest error, be conclusive and binding on Royalty Sub.

     SECTION 4.4. Funding Losses. In the event any Lender shall incur any loss
or expense (including any loss or expense incurred by reason of the liquidation
or reemployment of deposits or other funds acquired by such Lender to continue
any portion of the principal amount of any Loan as, or to convert any portion of
the principal amount of any Loan into, a LIBO Rate Loan) as a result of (a) any
conversion or repayment or prepayment of the principal amount of any LIBO Rate
Loan on a date other than the scheduled last day of the Interest Period
applicable thereto, whether pursuant to Article III or otherwise or (b) any
Loans not being continued as, or converted into, LIBO Rate Loans in accordance
with the Continuation/Conversion Notice therefor, then, upon the written notice
of such Lender to Royalty Sub (with a copy to the Administrative Agent), Royalty
Sub shall, upon the Payment Date immediately following its receipt thereof
(subject to the terms of the Intercreditor Agreement), pay directly to such
Lender such amount as will (in the reasonable determination of such Lender)
reimburse such Lender for such loss or expense. Such written notice shall, in
the absence of manifest error, be conclusive and binding on Royalty Sub.

     SECTION 4.5. Increased Capital Costs. If any change in, or the
introduction, adoption, effectiveness, interpretation, reinterpretation or
phase-in of, any law or regulation, directive, guideline, decision or request
(whether or not having the force of law) of any Governmental Authority affects
or would affect the amount of capital required or expected to be maintained by
any Secured Party or any Person controlling such Secured Party, and such Secured
Party determines (in good faith but in its sole and absolute discretion) that
the rate of return on its or such controlling Person's capital as a consequence
of the Commitments or the Loans made by such Secured Party is reduced to a level
below that which such Secured Party or such controlling Person could have
achieved but for the occurrence of any such circumstance, then upon notice from
time to time by such Secured Party to Royalty Sub, Royalty Sub shall upon the
Payment Date immediately following receipt of such notice (subject to the terms
of the Intercreditor Agreement) pay directly to such Secured Party additional
amounts sufficient to compensate such Secured Party or such controlling Person
for such reduction in rate of return. A statement of such Secured Party as to
any such additional amount or amounts shall, in the absence of manifest error,
be conclusive and binding on Royalty Sub. In determining such amount, such
Secured Party may use any method of averaging and attribution that it (in its
sole and absolute discretion) shall deem applicable.

     SECTION 4.6. Taxes. Royalty Sub covenants and agrees as follows with
respect to Taxes.

     (a) Any and all payments by Royalty Sub under each Loan Document shall be
made without setoff, counterclaim or other defense, and free and clear of, and
without deduction or withholding for or on account of, any Taxes. In the event
that any Taxes are imposed and

                                       -7-
<PAGE>
required to be deducted or withheld from any payment required to be made by any
Obligor to or on behalf of any Secured Party under any Loan Document, then:

          (i) subject to clause (f), if such Taxes are Non-Excluded Taxes, the
     amount of such payment shall be increased as may be necessary so that such
     payment is made, after withholding or deduction for or on account of such
     Taxes, in an amount that is not less than the amount provided for in such
     Loan Document; and

          (ii) Royalty Sub shall withhold the full amount of such Taxes from
     such payment (as increased pursuant to clause (a)(i)) and shall pay such
     amount to the Governmental Authority imposing such Taxes in accordance with
     applicable law.

     (b) In addition, Royalty Sub shall pay all Other Taxes imposed to the
relevant Governmental Authority imposing such Other Taxes in accordance with
applicable law.

     (c) As promptly as practicable after the payment of any Taxes or Other
Taxes, and in any event within 45 days of any such payment being due, Royalty
Sub shall furnish to the Administrative Agent a copy of an official receipt (or
a certified copy thereof) evidencing the payment of such Taxes or Other Taxes.
The Administrative Agent shall make copies thereof available to any Lender upon
request therefor.

     (d) Subject to clause (f), Royalty Sub shall indemnify each Secured Party
for any Non-Excluded Taxes and Other Taxes levied, imposed or assessed on (and
whether or not paid directly by) such Secured Party whether or not such
Non-Excluded Taxes or Other Taxes are correctly or legally asserted by the
relevant Governmental Authority. Promptly upon having knowledge that any such
Non-Excluded Taxes or Other Taxes have been levied, imposed or assessed, and
promptly upon notice thereof by any Secured Party, Royalty Sub shall pay such
Non-Excluded Taxes or Other Taxes directly to the relevant Governmental
Authority (provided that no Secured Party shall be under any obligation to
provide any such notice to Royalty Sub). In addition, Royalty Sub shall
indemnify each Secured Party for any incremental Taxes that may become payable
by such Secured Party as a result of any failure of Royalty Sub to pay any Taxes
when due to the appropriate Governmental Authority or to deliver to the
Administrative Agent, pursuant to clause (c), documentation evidencing the
payment of Taxes or Other Taxes. With respect to indemnification for
Non-Excluded Taxes and Other Taxes actually paid by any Secured Party or the
indemnification provided in the immediately preceding sentence, such
indemnification shall be made on the Payment Date immediately following the date
such Secured Party makes written demand therefor (subject to the terms of the
Intercreditor Agreement). Royalty Sub acknowledges that any payment made to any
Secured Party or to any Governmental Authority in respect of the indemnification
obligations of Royalty Sub provided in this clause shall constitute a payment in
respect of which the provisions of clause (a) and this clause shall apply.

     (e) Each Non-U.S. Lender, on or prior to the date on which such Non-U.S.
Lender becomes a Lender hereunder (and from time to time thereafter upon the
request of Royalty Sub or the Administrative Agent, but only for so long as such
Non-U.S. Lender is legally entitled to do so), shall deliver to Royalty Sub and
the Administrative Agent either (i) two duly completed copies of any of
(x) Internal Revenue Service Form W-8BEN claiming eligibility of the Non-U.S.

                                       -8-
<PAGE>

Lender for benefits of an income tax treaty to which the United States is a
party, (y) Internal Revenue Service Form W-8ECI, or (z) Internal Revenue Service
Form W-8IMY and any necessary withholding certificates, documentation and
withholding statements, or in each case an applicable successor form; or (ii) in
the case of a Non-U.S. Lender that is not legally entitled to deliver one of the
three forms listed in clause (e)(i), (x) a certificate to the effect that such
Non-U.S. Lender is not (A) a "bank" within the meaning of Section 881(c)(3)(A)
of the Code, (B) a "10 percent shareholder" of Royalty Sub within the meaning of
Section 881(c)(3)(B) of the Code, or (C) a controlled foreign corporation
receiving interest from a related person within the meaning of Section
881(c)(3)(C) of the Code (referred to as an "Exemption Certificate") and (y) two
duly completed copies of Internal Revenue Service Form W-8BEN or applicable
successor form.

     (f) Royalty Sub shall not be obligated to pay any additional amounts to any
Lender pursuant to clause (a)(i), or to indemnify any Lender pursuant to clause
(d), in respect of United States federal withholding taxes to the extent imposed
as a result of (i) the failure of such Lender to deliver to Royalty Sub the form
or forms and/or an Exemption Certificate, as applicable to such Lender, pursuant
to clause (e), (ii) such form or forms and/or Exemption Certificate not
establishing a complete exemption from U.S. federal withholding tax or the
information or certifications made therein by the Lender being untrue or
inaccurate on the date delivered in any material respect, or (iii) the Lender
designating a successor lending office at which it maintains its Loans which has
the effect of causing such Lender to become obligated for tax payments in excess
of those in effect immediately prior to such designation; provided that Royalty
Sub shall be obligated to pay additional amounts to any such Lender pursuant to
clause (a)(i), and to indemnify any such Lender pursuant to clause (d), in
respect of United States federal withholding taxes if (i) any such failure to
deliver a form or forms or an Exemption Certificate or the failure of such form
or forms or Exemption Certificate to establish a complete exemption from U.S.
federal withholding tax or inaccuracy or untruth contained therein resulted from
a change in any applicable statute, treaty, regulation or other applicable law
or any interpretation of any of the foregoing occurring after the Closing Date,
which change rendered such Lender no longer legally entitled to deliver such
form or forms or Exemption Certificate or otherwise ineligible for a complete
exemption from U.S. federal withholding tax, or rendered the information or
certifications made in such form or forms or Exemption Certificate untrue or
inaccurate in a material respect, (ii) the redesignation of the Lender's lending
office was made at the request of Royalty Sub or (iii) the obligation to pay any
additional amounts to any such Lender pursuant to clause (a)(i) or to indemnify
any such Lender pursuant to clause (d) is with respect to an assignee Lender
that becomes an assignee Lender as a result of an assignment made at the request
of Royalty Sub.

     (g) If (i) Royalty Sub is required to pay additional amounts to any Lender
(an "Affected Lender") pursuant to clause (a)(i), or to indemnify an Affected
Lender pursuant to clause (d), in respect of Taxes as a result of a change in
any applicable statute, treaty, regulation or other applicable law or any
interpretation of any of the foregoing occurring after the Closing Date and (ii)
the payment of such amounts, in the reasonable judgment of Royalty Sub, is and
is likely to continue to be more onerous with respect to such Affected Lender
than with respect to other Lenders, Royalty Sub may, within 30 days of receipt
by Royalty Sub of any demand or notice from such Affected Lender (or the
Administrative Agent on behalf of such Affected Lender) to pay any such
additional amounts, give notice (a "Replacement Notice") in writing to the
Administrative Agent and such Affected Lender of Royalty Sub's intention to
replace such Affected Lender with an Eligible Assignee (a "Replacement Lender")
as designated in such

                                       -9-
<PAGE>
Replacement Notice; provided that no Replacement Notice may be given by Royalty
Sub if (x) such replacement conflicts with any applicable law or regulation, (y)
any Event of Default shall have occurred and be continuing at the time of such
replacement or (z) prior to any such replacement, such Affected Lender shall
have taken any necessary action under this Section so as to eliminate the
continued need for payment of amounts owing pursuant to clause (a)(i) or clause
(d). If the Administrative Agent shall, within 30 days of its receipt of such
Replacement Notice, notify Royalty Sub and such Affected Lender in writing that
the Administrative Agent has consented to such Replacement Lender (such consent
not to be unreasonably withheld, and such consent not being required if the
Replacement Lender is already a Lender), then such Affected Lender shall,
subject to the payment of any amounts due pursuant to Section 4.4, assign, in
accordance with Section 10.11, all of its Loans, Notes (if any) and other rights
and obligations under this Agreement and all other Loan Documents to such
Replacement Lender; provided that (A) such assignment shall be without recourse,
representation or warranty and shall be on terms and conditions reasonably
satisfactory to such Affected Lender and such Eligible Assignee, (B) the
purchase price paid by such Replacement Lender shall be in the amount of such
Affected Lender's Loans, together with all accrued and unpaid interest in
respect thereof, plus all other amounts (including the amounts demanded and
unreimbursed under this Section and any applicable amounts due pursuant to
Section 4.4) owing to such Affected Lender hereunder, (C) Royalty Sub shall pay
to the Affected Lender and the Administrative Agent all reasonable out-of-pocket
expenses incurred by the Affected Lender and the Administrative Agent in
connection with such assignment and assumption and (D) if a Lender Assignment
Agreement is executed by the Replacement Lender and, to the extent applicable,
the Administrative Agent in accordance with Section 10.11 and all amounts
referred to in clause (B) above shall have been paid to the Affected Lender,
then such Affected Lender shall, for all purposes of this Agreement, be deemed
to have executed and delivered such Lender Assignment Agreement. Upon the
effective date of an assignment described above, the Replacement Lender shall
become a "Lender" for all purposes under the Loan Documents.

     SECTION 4.7. Payments, Computations; Proceeds of Collateral, etc. Unless
otherwise expressly provided in a Loan Document, all payments by Royalty Sub
pursuant to each Loan Document shall be made by Royalty Sub to the Collection
Account for application pursuant to the terms of the Intercreditor Agreement.
All payments received by the Administrative Agent shall be applied for the pro
rata account of the Secured Parties entitled to receive such payment and shall
be made without setoff, deduction or counterclaim. Funds received after 11:00
a.m. on any date shall be deemed to have been received by the Administrative
Agent on the next succeeding Business Day. The Administrative Agent shall
promptly remit in same day funds to each Secured Party its share, if any, of
such payments received by the Administrative Agent for the account of such
Secured Party. All interest (including interest on LIBO Rate Loans) and fees
shall be computed on the basis of the actual number of days (including the first
day but excluding the last day) occurring during the period for which such
interest or fee is payable over a year comprised of 360 days (or, in the case of
interest on a Base Rate Loan (calculated at other than the Federal Funds Rate),
365 days or, if appropriate, 366 days). Payments due on other than a Business
Day shall (except as otherwise described in the definition of "Payment Date") be
made on the next succeeding Business Day and such extension of time shall be
included in computing interest and fees in connection with that payment.

                                      -10-
<PAGE>
     SECTION 4.8. Sharing of Payments. If any Secured Party shall obtain any
payment or other recovery (whether voluntary, involuntary, by application of
setoff or otherwise) on account of any Loan (other than pursuant to the terms of
Sections 4.3, 4.4, 4.5 or 4.6) in excess of its pro rata share of payments
obtained by all Secured Parties, such Secured Party shall purchase from the
other Secured Parties such participations in Loans made by them as shall be
necessary to cause such purchasing Secured Party to share the excess payment or
other recovery ratably (to the extent such other Secured Parties were entitled
to receive a portion of such payment or recovery) with each of them; provided
that if all or any portion of the excess payment or other recovery is thereafter
recovered from such purchasing Secured Party, the purchase shall be rescinded
and each Secured Party which has sold a participation to the purchasing Secured
Party shall repay to the purchasing Secured Party the purchase price to the
ratable extent of such recovery together with an amount equal to such selling
Secured Party's ratable share (according to the proportion of (a) the amount of
such selling Secured Party's required repayment to the purchasing Secured Party
to (b) total amount so recovered from the purchasing Secured Party) of any
interest or other amount paid or payable by the purchasing Secured Party in
respect of the total amount so recovered. Royalty Sub agrees that any Secured
Party purchasing a participation from another Secured Party pursuant to this
Section may, to the fullest extent permitted by law, exercise all its rights of
payment (including pursuant to Section 4.9) with respect to such participation
as fully as if such Secured Party were the direct creditor of Royalty Sub in the
amount of such participation. If under any applicable bankruptcy, insolvency or
other similar law any Secured Party receives a secured claim in lieu of a setoff
to which this Section applies, such Secured Party shall, to the extent
practicable, exercise its rights in respect of such secured claim in a manner
consistent with the rights of the Secured Parties entitled under this Section to
share in the benefits of any recovery on such secured claim.

     SECTION 4.9. Setoff. Each Secured Party shall, upon the occurrence and
during the continuance of any Default described in clause (g) of Section 8.1 or,
with the consent of the Required Lenders, upon the occurrence and during the
continuance of any other Event of Default, have the right to appropriate and
apply to the payment of the Obligations owing to it (whether or not then due),
and (as security for such Obligations) Royalty Sub hereby grants to each Secured
Party a continuing Lien in, any and all balances, credits, deposits, accounts or
moneys of Royalty Sub then or thereafter maintained with such Secured Party;
provided that any such appropriation and application shall be subject to the
provisions of Section 4.8 and the terms of the Intercreditor Agreement. Each
Secured Party agrees promptly to notify Royalty Sub and the Administrative Agent
after any such appropriation and application made by such Secured Party;
provided that the failure to give such notice shall not affect the validity of
such setoff and application. The rights of each Secured Party under this Section
are in addition to other rights and remedies (including other rights of setoff
under applicable law or otherwise) which such Secured Party may have.

                                    ARTICLE V
                               CONDITIONS TO LOANS

     The obligations of the Lenders to make Loans on the Closing Date shall be
subject to the prior or concurrent satisfaction of each of the conditions
precedent set forth in this Article V.

                                      -11-
<PAGE>
     SECTION 5.1. Resolutions, etc. The Administrative Agent shall have received
from each of Royalty Sub, the Pledgor and Quintiles, dated as of the Closing
Date, duly executed and delivered by such Person's Secretary or Assistant
Secretary, managing member or general partner, as applicable, certificates as to

          (a) resolutions of each such Person's Board of Directors (or other
     managing body, in the case of other than a corporation) then in full force
     and effect authorizing, to the extent relevant, all aspects of the
     Transaction applicable to such Person and the execution, delivery and
     performance of each Loan Document to be executed by such Person and the
     transactions contemplated hereby and thereby;

          (b) the incumbency and signatures of those of its officers, managing
     member or general partner, as applicable, authorized to act with respect to
     each Loan Document to be executed by such Person; and

          (c) the full force and validity of each Organic Document of such
     Person and copies thereof;

upon which certificates each Secured Party may conclusively rely until it shall
have received a further certificate of the Secretary, Assistant Secretary,
managing member or general partner, as applicable, of any such Person canceling
or amending the prior certificate of such Person.

     SECTION 5.2. Closing Date Certificate. The Administrative Agent shall have
received the Closing Date Certificate, dated as of the Closing Date and duly
executed and delivered by an Authorized Officer of Royalty Sub, in which
certificate Royalty Sub shall agree and acknowledge that the statements made
therein shall be deemed to be true and correct representations and warranties of
Royalty Sub as of such date, and, at the time each such certificate is
delivered, such statements shall in fact be true and correct. All documents and
agreements (including Transaction Documents) required to be appended to the
Closing Date Certificate shall be in form and substance satisfactory to the
Administrative Agent, shall have been executed and delivered by the requisite
parties, and shall be in full force and effect.

     SECTION 5.3. Compliance with Warranties, no Default, etc. The
Administrative Agent shall have received (a) a certificate, dated as of the
Closing Date and duly executed and delivered by an Authorized Officer of Royalty
Sub, certifying that (i) the representations and warranties set forth in each
Loan Document executed and delivered by it (A) that are not qualified by
materiality shall, in each case, be true and correct in all material respects
with the same effect as if then made (unless stated to relate solely to an
earlier date, in which case such representations and warranties shall be true
and correct in all material respects as of such earlier date) and (B) that are
qualified by materiality shall, in each case, be true and correct in all
respects with the same effect as if then made (unless stated to relate solely to
an earlier date, in which case such representations and warranties shall be true
and correct in all respects as of such earlier date), and (ii) no Default shall
have then occurred and be continuing, and (b) a certificate, dated as of the
Closing Date and duly executed and delivered by an authorized officer of each of
the Pledgor and Quintiles, certifying that (i) the respective representations
and warranties set forth in this Agreement executed and delivered by each of
them (A) that are not qualified by materiality shall, in each case, be true and
correct in all material respects with the same effect as if then made

                                      -12-
<PAGE>
(unless stated to relate solely to an earlier date, in which case such
representations and warranties shall be true and correct in all material
respects as of such earlier date) and (B) that are qualified by materiality
shall, in each case, be true and correct in all respects with the same effect as
if then made (unless stated to relate solely to an earlier date, in which case
such representations and warranties shall be true and correct in all respects as
of such earlier date), and (ii) no Default shall have then occurred and be
continuing.

     SECTION 5.4. Consummation of Transaction. The Administrative Agent shall
have received evidence satisfactory to it that all actions necessary to
consummate the Transaction shall have been taken in material compliance with all
Applicable Law and in accordance with the terms of each applicable Transaction
Document, without amendment or waiver of any material provision thereof. The
Administrative Agent shall have received copies of the Transaction Documents (as
well as all other closing documentation executed or delivered in connection
therewith, but excluding the Note Purchase Agreements) executed and delivered by
the parties thereto, each of which shall be in full force and effect. The
Administrative Agent shall have received evidence satisfactory to it that the
Second Lien Note Documents shall have been executed and delivered and that the
proceeds of the Second Lien Notes shall have been made available to Royalty Sub
in an amount sufficient, when taken together with the proceeds of the Loans, to
consummate the Transaction.

     SECTION 5.5. Delivery of Notes. The Administrative Agent shall have
received, for the account of each Lender that has requested a Note, such
Lender's Notes duly executed and delivered by an Authorized Officer of Royalty
Sub.

     SECTION 5.6. Security Agreements. The Administrative Agent shall have
received, with counterparts for each Lender, executed counterparts of the Loan
Security Agreement and the First Lien Pledge and Security Agreement, each dated
as of the Closing Date, duly executed by the applicable Obligor party thereto,
together with

          (a) evidence that certificates evidencing all of the issued and
     outstanding Capital Securities owned by the Pledgor of Royalty Sub and
     pledged under the First Lien Pledge and Security Agreement shall have been
     delivered to the Administrative Agent, which certificates in each case
     shall be accompanied by undated instruments of transfer duly executed in
     blank;

          (b) copies of Filing Statements suitable in form for naming the
     Pledgor and Royalty Sub as a debtor and the Administrative Agent as the
     secured party, or other similar instruments or documents to be filed under
     the UCC of all jurisdictions as may be necessary or, in the opinion of the
     Administrative Agent, desirable to perfect the Liens of the Administrative
     Agent pursuant to each such Security Agreement, and copies of Uniform
     Commercial Code financing statements to be filed in connection with the
     Purchase and Sale Agreement naming Quintiles as a debtor and Royalty Sub as
     the secured party;

          (c) certified copies of UCC Requests for Information or Copies (Form
     UCC-11), or a similar search report certified by a party acceptable to the
     Administrative Agent, dated a date reasonably near to the Closing Date,
     listing all effective financing

                                      -13-
<PAGE>
     statements which name any Obligor (under its present name and any previous
     names) as the debtor, together with copies of such financing statements
     (none of which shall evidence a Lien on any collateral described in any
     Loan Document); and

          (d) a copy of a deposit and securities account control agreement
     executed and delivered by each of Royalty Sub, the Administrative Agent,
     the Trustee and U.S. Bank National Association, the deposit bank and/or
     custodian with respect to each Account, sufficient to enable the
     Administrative Agent (or its agent) to have and maintain control over each
     Account.

     SECTION 5.7. Filing Agent, etc. All Uniform Commercial Code financing
statements or other similar financing statements required pursuant to the Loan
Documents (collectively, the "Filing Statements") shall have been delivered to
CSC Corporation or another similar filing service company acceptable to the
Administrative Agent (the "Filing Agent"). The Filing Agent shall have
acknowledged in a writing satisfactory to the Administrative Agent and its
counsel (i) the Filing Agent's receipt of all Filing Statements, (ii) that the
Filing Statements have either been submitted for filing in the appropriate
filing offices or will be submitted for filing in the appropriate offices within
ten days following the Closing Date and (iii) that the Filing Agent will notify
the Administrative Agent and its counsel of the results of such submissions
within 30 days following the Closing Date.

     SECTION 5.8. Opinions of Counsel. The Administrative Agent shall have
received opinions, dated the Closing Date and addressed to the Administrative
Agent and all Lenders, from

          (a) Pillsbury Winthrop Shaw Pittman LLP, as to certain intellectual
     property matters set forth therein in form and substance satisfactory to
     the Administrative Agent;

          (b) Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan, L.L.P.,
     special counsel to Royalty Sub, in form and substance satisfactory to the
     Administrative Agent; and

          (c) Walkers, special counsel to Royalty Sub and the Pledgor, in form
     and substance satisfactory to the Administrative Agent.

     SECTION 5.9. Intercreditor Agreement. The Administrative Agent shall have
received, with counterparts for each Lender, the Intercreditor Agreement, duly
executed by each party thereto.

     SECTION 5.10. Co-Promotion Agreement. The Co-Promotion Agreement, including
the Second Amendment thereto, in the form previously furnished by Quintiles to
counsel to the Administrative Agent, shall have been executed and delivered by
Quintiles and Lilly and shall be in full force and effect, and the
Administrative Agent shall have received upon prior written request therefor a
true, correct and complete copy of the Co-Promotion Agreement, as amended and
supplemented, as such agreement may be redacted by Quintiles or Lilly for the
protection of certain information.

                                      -14-
<PAGE>
     SECTION 5.11. Notice to Lilly. The Administrative Agent shall have received
a copy of the notice provided to Lilly by Quintiles pursuant to Section 4.1 of
the Purchase and Sale Agreement instructing Lilly to make all Royalty Sub
Payments after the Closing Date to the Collection Account, which notice shall be
certified by a responsible officer of Quintiles as having been sent to Lilly
prior to the Closing Date.

     SECTION 5.12. Borrowing Request. The Administrative Agent shall have
received a Borrowing Request in accordance with the terms of Section 2.2.

     SECTION 5.13. Hedge Agreement. The Administrative Agent shall have received
evidence satisfactory to it that Royalty Sub shall have entered into the Hedge
Agreement.

     SECTION 5.14. Patriot Act Disclosures. The Lenders shall have received all
Patriot Act disclosures reasonably requested by them prior to the Closing Date.

     SECTION 5.15. Closing Fees, Expenses, etc. The Administrative Agent shall
have received for its own account, or for the account of each Lender, as the
case may be, all fees, costs and expenses due and payable pursuant to Section
10.3.

     SECTION 5.16. Satisfactory Legal Form. All documents executed or submitted
pursuant hereto by or on behalf of any Obligor shall be reasonably satisfactory
in form and substance to the Administrative Agent and its counsel, and the
Administrative Agent and its counsel shall have received all information,
approvals, opinions, documents or instruments as the Administrative Agent or its
counsel may reasonably request.

                                   ARTICLE VI
                         REPRESENTATIONS AND WARRANTIES

     In order to induce the Secured Parties to enter into this Agreement and to
make Loans hereunder, each of Royalty Sub, the Pledgor and Quintiles, as
applicable, represents and warrants to each Secured Party as set forth in this
Article VI.

     SECTION 6.1. Representations and Warranties of Royalty Sub. Royalty Sub
represents and warrants to each Secured Party as follows:

          (a) Royalty Sub is an exempted company incorporated with limited
     liability created under the laws of the Cayman Islands, is duly qualified
     to do business and is in good standing in each jurisdiction where such
     qualification is required, and has full power and authority to conduct its
     business, and Royalty Sub has not become subject to a Voluntary Bankruptcy
     or an Involuntary Bankruptcy.

          (b) Royalty Sub has not engaged in any activities since its
     organization (other than those incidental to its organization and permitted
     by its organizational documents, the execution of the Loan Documents and
     the Transaction Documents to which it is a party and the activities
     referred to in or contemplated by such agreements), and Royalty Sub has not
     paid any dividends, distributions or other Restricted Payments since its
     organization.

                                      -15-
<PAGE>
          (c) The Borrowing of the Loans and the execution and delivery, and the
     compliance by Royalty Sub with the terms, of the Loan Documents and each of
     the Transaction Documents to which it is a party:

               (i) do not at the Closing Date (A) conflict with, result in a
          breach of any of the terms or provisions of or constitute a default
          under the Organic Documents of Royalty Sub, or (B) conflict with any
          judgment, order or decree of any Governmental Authority having
          jurisdiction over Royalty Sub, or (C) except to the extent it would
          not have or be reasonably likely to have a Material Adverse Effect,
          conflict with any Applicable Law; and

               (ii) do not at the Closing Date violate, or constitute a default
          under, any deed, indenture, agreement or other instrument or
          obligation to which Royalty Sub is a party or by which it or any part
          of its assets, property or revenues are bound.

          (d) The borrowing of the Loans, the execution and delivery by Royalty
     Sub of the Loan Documents and the Transaction Documents executed by it and
     the performance by Royalty Sub of its obligations hereunder and thereunder
     and the arrangements contemplated hereby and thereby to be performed by it
     have been duly authorized, executed and delivered by Royalty Sub.

          (e) This Agreement constitutes, and the other Loan Documents and the
     Transaction Documents to which it is a party, when executed and delivered
     will constitute, valid, legally binding and (subject to general equitable
     principles, and laws relating to insolvency, liquidation, reorganization
     and other laws of general application relating to creditors' rights or
     claims or to laws of prescription or the concepts of materiality,
     reasonableness, good faith and fair dealing) enforceable obligations of
     Royalty Sub.

          (f) On the Closing Date, there exists no Event of Default nor any
     event which, had the Loans already been made, would constitute a Default or
     an Event of Default.

          (g) On the Closing Date, subject to the Liens created in favor of the
     Administrative Agent and except for Permitted Liens, there exists no Lien
     over the assets of Royalty Sub.

          (h) Royalty Sub has determined, and by virtue of its entering into the
     transactions contemplated hereby and its authorization, execution and
     delivery of this Agreement, the other Loan Documents and the other
     Transaction Documents to which it is party, the making of the Loans, the
     issuance of the Second Lien Notes and the consummation of the Transaction,
     that its incurrence of Indebtedness and other liability hereunder or
     thereunder or contemplated hereby or thereby (i) is in its own best
     interests, (ii) does not leave it unable to pay its debts as they become
     due in the ordinary course of business, (iii) will not leave it with debts
     which cannot be paid from the present saleable value of its property and
     (iv) will not render it insolvent within the meaning of Section

                                      -16-
<PAGE>
     101(31) of the United States Bankruptcy Code or Section 271 of the New York
     Debtor and Creditor Law.

          (i) All consents, approvals, authorizations or other orders of all
     Governmental Authorities required (excluding any required by the other
     parties to the Loan Documents) for or in connection with the execution,
     delivery and performance of the Loan Documents by Royalty Sub have been
     obtained and are in full force and effect and are not contingent upon
     fulfillment of any condition. Royalty Sub is not an "investment company"
     within the meaning of the Investment Company Act of 1940, as amended, or a
     "holding company", or a "subsidiary company" of a "holding company", or an
     "affiliate" of a "holding company" or of a "subsidiary company" of a
     "holding company", within the meaning of the Public Utility Holding Company
     Act of 1935, as amended.

          (j) There is no action, suit, investigation or proceeding pending or,
     to the knowledge of Royalty Sub, threatened against Royalty Sub before any
     court or arbitrator or any governmental body, agency or official which in
     any manner challenges or seeks to prevent, enjoin, alter or materially
     delay the transactions contemplated by this Agreement and the other Loan
     Documents to which Royalty Sub is a party.

          (k) Royalty Sub has no Subsidiaries.

          (l) Royalty Sub is the legal and beneficial owner of Royalty Sub
     Rights and the other assets and property constituting the Collateral, free
     and clear of any Liens other than Permitted Liens.

          (m) Under the laws of the Cayman Islands, the laws of the State of New
     York and U.S. federal law in force at the Closing Date, it is not necessary
     or desirable that this Agreement or any other Loan Document (other than
     evidences and perfection of the Liens) be filed, recorded or enrolled by
     Royalty Sub with any court or other Governmental Authority in any such
     jurisdictions or that any stamp, registration or similar Tax be paid by
     Royalty Sub on or in relation to this Agreement or any of the other Loan
     Documents (other than the filing of the Filing Statements).

          (n) The filing of the Filing Statements and other recordings, if any,
     required to perfect a Lien in favor of the Administrative Agent in Royalty
     Sub Rights sold, transferred, conveyed, assigned, contributed and granted
     on the Closing Date pursuant to the Purchase and Sale Agreement have been
     or shall have been duly made by the Closing Date, and, subject to the
     provisions of the Intercreditor Agreement, the Administrative Agent has or
     shall have the same rights as Quintiles or the Pledgor has or would have
     with respect to Royalty Sub Rights (if Quintiles or the Pledgor, as the
     case may be, were still the owner of such Royalty Sub Rights) against
     Lilly.

          (o) The representations and warranties made by Royalty Sub in any of
     the other Loan Documents or Transaction Documents to which it is a party
     are true and accurate as of the date made.

                                      -17-
<PAGE>
          (p) No material adverse change in the business, condition (financial
     or otherwise), performance or properties of Royalty Sub has occurred since
     its date of formation.

          (q) Royalty Sub has filed all tax returns and reports required by law
     to have been filed by it and has paid all Taxes thereby shown to be due and
     owing, except any such Taxes which are being diligently contested in good
     faith by appropriate proceedings and for which adequate reserves in
     accordance with GAAP shall have been set aside on its books. Royalty Sub
     has never filed any tax return or report under any name other than its
     exact legal name.

          (r) No conditions exist at, on or under any property now or previously
     owned or leased by Royalty Sub which, with the passage of time, or the
     giving of notice or both, would give rise to material liability under any
     Environmental Law.

          (s) No step has been taken or is intended by Royalty Sub or, so far as
     it is aware, any other Person for the winding-up, liquidation, dissolution,
     administration, merger or consolidation or for the appointment of a
     receiver or administrator of Royalty Sub or all or any of its assets, and,
     immediately after the sale, transfer, conveyance, assignment, contribution
     and granting of the Royalty Sub Rights on the Closing Date, Royalty Sub
     will not be rendered insolvent or be unable to pay its debts as they mature
     or be left with unreasonably small capital.

     SECTION 6.2. Representations and Warranties of Royalty Sub, the Pledgor and
Quintiles. Each of Royalty Sub, the Pledgor and Quintiles, jointly and
severally, represents and warrants to each Secured Party as follows:

          (a) This Agreement has been duly authorized, executed and delivered by
     the Pledgor and Quintiles and constitutes the valid, legally binding and
     (subject to general equitable principles, insolvency, liquidation,
     reorganization and other laws of general application relating to creditors'
     rights) enforceable obligations of the Pledgor and Quintiles.

          (b) The Pledgor is not an "investment company" within the meaning of
     the Investment Company Act of 1940, as amended.

          (c) No consent, approval or authorization of, or registration, filing
     or declaration with, any Governmental Authority is required in connection
     with the execution, delivery or performance by Quintiles or the Pledgor of
     this Agreement or the transactions contemplated hereby other than, in the
     case of Quintiles, such filings as shall have been made prior to the date
     of this Agreement and such filings required to be made after the date of
     this Agreement under Applicable Laws.

          (d) During the twelve-consecutive-month period prior to the Effective
     Date and prior to the date of any Loan hereunder, no steps have been taken
     to terminate any Pension Plan, and no contribution failure has occurred
     with respect to any Pension Plan. None of Royalty Sub, Pledgor or
     Quintiles, nor any ERISA Affiliate, has ever maintained a Pension Plan that
     is or was subject to Title IV of ERISA. No condition exists or event

                                      -18-
<PAGE>
     or transaction has occurred with respect to any Pension Plan which might
     result in the incurrence by Quintiles, the Pledgor, Royalty Sub or any
     member of the Controlled Group of any material liability, fine or penalty.
     Except as described in Quintiles' filings with the Securities and Exchange
     Commission, none of Quintiles, the Pledgor, Royalty Sub or any member of
     the Controlled Group has any contingent liability with respect to any
     post-retirement benefit under a Welfare Plan, other than liability for
     continuation coverage described in Part 6 of Title I of ERISA. The
     execution and delivery of this Agreement and the making of the Loans
     hereunder will not involve any transaction that is subject to the
     prohibitions of Section 406 of ERISA or in connection with which a tax
     could be imposed pursuant to Sections 4975(c)(1)(A)-(D) of the Code.

          (e) None of Royalty Sub, the Pledgor or Quintiles has any reason to
     believe that the Product sales forecast projections included in the
     Independent Consultant's Report (i) are not based upon assumptions (as they
     are described in the Independent Consultant's Report) that Royalty Sub, the
     Pledgor or Quintiles reasonably believes in good faith to be consistent in
     all material respects with the operation of the Co-Promotion Agreement and
     (ii) are not reasonable, taking into account such assumptions. The
     Administrative Agent acknowledges, however, that none of Quintiles, the
     Pledgor or Royalty Sub participated in the preparation of the Independent
     Consultant's Report or analyzed the methodology applied in reaching the
     conclusions set forth therein.

          (f) Each of the representations and warranties made by Royalty Sub in
     the other Transaction Documents, by Quintiles and the Pledgor in Section 5
     of the Purchase and Sale Agreement and by the Pledgor in Section 4.1 of the
     First Lien Pledge and Security Agreement, is hereby incorporated herein by
     reference as if fully set forth herein and given for the benefit of the
     Secured Parties.

          (g) None of the factual information (except for the sales forecast
     projections and related financial model provided to the Secured Parties and
     prepared by the Independent Consultant) heretofore or contemporaneously
     furnished in writing to any Secured Party by or on behalf of any Obligor in
     connection with any Loan Document or any transaction contemplated hereby
     (including the Transaction) contains any untrue statement of a material
     fact, or omits to state any material fact necessary to make any information
     not misleading, and no other factual information hereafter furnished in
     connection with any Loan Document by or on behalf of any Obligor to any
     Secured Party will contain any untrue statement of a material fact or will
     omit to state any material fact necessary to make any information not
     misleading on the date as of which such information is dated or certified.

          (h) No Obligor is engaged in the business of extending credit for the
     purpose of buying or carrying margin stock, and no proceeds of any Loans
     will be used to purchase or carry margin stock or otherwise for a purpose
     which violates, or would be inconsistent with, F.R.S. Board Regulation U or
     Regulation X. Terms for which meanings are provided in F.R.S. Board
     Regulation U or Regulation X or any regulations substituted therefor, as
     from time to time in effect, are used in this Section with such meanings.

                                      -19-
<PAGE>
          (i) Section 9.9 of the Purchase and Sale Agreement is enforceable to
     govern any Liquidated Damages Event that may occur.

                                   ARTICLE VII
                                    COVENANTS

     SECTION 7.1. Affirmative Covenants. Royalty Sub agrees with each Lender and
the Administrative Agent that until the Termination Date has occurred, Royalty
Sub will perform or cause to be performed the obligations set forth below.

     SECTION 7.1.1. Financial Information, Reports, Notices, etc.

          (a) Royalty Sub will furnish to the Administrative Agent for the
     benefit of the Secured Parties, within 60 days after the end of each Fiscal
     Year, a certificate, in form and substance satisfactory to the
     Administrative Agent, from an Authorized Officer of Royalty Sub as to his
     or her knowledge of Royalty Sub's compliance with all of its obligations
     under this Agreement.

          (b) Royalty Sub shall deliver written notice to the Administrative
     Agent of the occurrence of (i) any Default or Event of Default and (ii) any
     of the events described in Section 6.4(e) of the Purchase and Sale
     Agreement promptly and in any event within five Business Days of any
     officer of Royalty Sub becoming aware of such Default, Event of Default,
     event or situation.

          (c) (i) To the extent not prohibited by obligations of confidentiality
     between Quintiles and Lilly, Royalty Sub shall promptly (but in no event
     more than five Business Days following its receipt thereof) provide to
     Servicer and the Administrative Agent for the benefit of the Secured
     Parties copies of any correspondence and (ii) Royalty Sub shall promptly
     (but in no event more than five Business Days following its receipt
     thereof) provide to Servicer and the Administrative Agent for the benefit
     of the Secured Parties copies of any notices (A) in the case of each of
     clause (i) and clause (ii), between Quintiles and Lilly with respect to the
     Co-Promotion Agreement, including quarterly net sales reports under Section
     5.10 of the Co-Promotion Agreement, if such correspondence or notices
     relate to or could reasonably be expected to affect the Royalty Sub Rights
     or (B) from Quintiles or the Pledgor pursuant to Section 6.1(j), 6.1(m) or
     6.4 of the Purchase and Sale Agreement.

          (d) Promptly upon becoming aware of (i) the institution of any steps
     by any Person to terminate any Pension Plan, (ii) the failure to make a
     required contribution to any Pension Plan if such failure is sufficient to
     give rise to a Lien under Section 302(f) of ERISA, (iii) the taking of any
     action with respect to a Pension Plan which could result in the requirement
     that any Obligor furnish a bond or other security to the PBGC or such
     Pension Plan, or (iv) the occurrence of any event with respect to any
     Pension Plan which could result in the incurrence by any Obligor of any
     material liability, fine or penalty, notice thereof and copies of all
     documentation relating thereto.

          (e) Royalty Sub shall furnish to the Administrative Agent a copy of
     each opinion of counsel furnished to the Trustee pursuant to Section 5.2(d)
     of the Indenture,

                                      -20-
<PAGE>
     upon which opinion the Administrative Agent and the Lenders shall be
     permitted to rely, which opinion shall state whether there are any actions
     to be taken, including any financing statements to be filed in any office,
     within the period of 12 full consecutive calendar months following the date
     of such opinion in order to continue the perfection of the security
     interests granted under the Loan Documents or the Transaction Documents.

          (f) Royalty Sub will provide such other financial and other
     information as any Lender through the Administrative Agent may from time to
     time reasonably request.

     SECTION 7.1.2. Maintenance of Existence; Compliance with Contracts, Laws,
etc. Royalty Sub will preserve and maintain its legal existence, perform its
obligations under material agreements to which Royalty Sub is a party, and
comply with all Applicable Laws and orders, including the payment (before the
same become delinquent) of all Taxes, imposed upon Royalty Sub or upon its
property except to the extent being diligently contested in good faith by
appropriate proceedings and for which adequate reserves in accordance with GAAP
have been set aside on the books of Royalty Sub.

     SECTION 7.1.3. Books and Records. Royalty Sub will keep books and records
which accurately reflect all of its business affairs and transactions and permit
each Secured Party or any of their respective representatives, at reasonable
times and intervals upon reasonable notice to Royalty Sub, to discuss Royalty
Sub's financial matters with its representatives and to examine (and photocopy
extracts from) any of its books and records. Royalty Sub will maintain its
register of shareholders at all times in the Cayman Islands.

     SECTION 7.1.4. Use of Proceeds. Royalty Sub will apply the proceeds of the
Loans as follows:

          (a) to finance, in part, the Acquisition; and

          (b) to pay fees and expenses incurred in connection with the
     Acquisition and the Transaction.

     SECTION 7.1.5. Further Assurances. Upon reasonable request of the
Administrative Agent, each of Royalty Sub and the Pledgor shall execute and
deliver such further instruments and take such further actions as may be
reasonably necessary or proper to carry out more effectively the transactions
contemplated by this Agreement.

     SECTION 7.2. Other Covenants. Royalty Sub covenants and agrees with each
Lender and the Administrative Agent that until the Termination Date has
occurred, Royalty Sub will perform or cause to be performed the obligations set
forth below:

          (a) Except as expressly permitted by any Loan Document, Royalty Sub
     shall not take any action, whether orally or in writing, which would amend,
     waive, modify, supplement, restate or cancel, terminate, discharge or
     prejudice the validity or effectiveness of, any Loan Document or the Hedge
     Agreement, or permit any party to any such document to be released from
     such obligations. In addition, Royalty Sub will not consent to any
     amendment, supplement, waiver or other modification of, or enter into any
     forbearance from exercising any rights with respect to the terms or
     provisions contained

                                      -21-
<PAGE>
     in any of, or take any action, whether orally or in writing, to discharge
     or prejudice the validity or effectiveness of, (i) any Second Lien Note
     Documents except as provided in the Intercreditor Agreement or, if not
     provided for therein, as otherwise permitted by such Second Lien Note
     Document or (ii) any Acquisition Document.

          (b) Royalty Sub shall not, directly or indirectly, (i) declare or pay
     any dividend, distribution or other Restricted Payment other than as
     expressly permitted in this Agreement, the Indenture or the Intercreditor
     Agreement, (ii) make any voluntary or optional redemption, repurchase,
     defeasance or other acquisition or retirement for value of Indebtedness of
     Royalty Sub other than as expressly permitted in this Agreement, the
     Indenture or the Intercreditor Agreement or (iii) make any loan or advance
     to a Person, any purchase or other acquisition of any beneficial interest,
     shares, warrants, rights, options, obligations or other securities of such
     Person, any capital contribution to such Person or any other Investment in
     such Person (other than Eligible Investments expressly permitted by the
     terms of the Intercreditor Agreement or as permitted under clause (f) of
     Section 7.2).

          (c) Royalty Sub shall not (and shall not consent to Quintiles or the
     Pledgor taking any action that would) incur or suffer to exist any Lien
     over or with respect to any of Royalty Sub's assets, other than (i) Liens
     securing the Obligations, (ii) Liens securing the obligations under the
     Second Lien Note Documents (subject to the terms of the Intercreditor
     Agreement) and (iii) any other Permitted Lien.

          (d) Royalty Sub shall not (i) incur, create, issue, assume, Guarantee
     or otherwise become liable for or with respect to, or become responsible
     for, the payment or performance of, contingently or otherwise, whether
     present or future (in any such case, to "Incur"), Indebtedness or other
     similar monetary obligations; provided, however, that Royalty Sub may Incur
     Indebtedness in respect of (x) the Obligations or any Refinancing thereof
     (as defined in the Intercreditor Agreement), (y) the Second Lien Notes in
     an aggregate principal amount not to exceed $125,000,000 or any Refinancing
     thereof (as defined in the Intercreditor Agreement) and (z) the Class B
     Notes (provided that in the case of clause (z), (A) the net proceeds from
     the issuance of such Class B Notes are deposited in the
     Repayment/Redemption Account to the extent required to voluntarily prepay
     the Loans (or a portion thereof) and the other Obligations pursuant to
     clause (a) of Section 3.1.1 and distributed as provided in the
     Intercreditor Agreement and (B) such Class B Notes constitute Indebtedness
     of Royalty Sub subordinated in right of payment to the Obligations on
     subordination terms reasonably satisfactory to the Administrative Agent and
     are issued pursuant to the Indenture) or (ii) make any payment or
     prepayment of principal of, or premium or interest or other amounts on, or
     redeem, retire, purchase, defease or otherwise acquire, or make any deposit
     (including the payment of amounts into a sinking fund or other similar
     fund) with respect to, any Indebtedness which would violate the terms of
     this Agreement, the Indenture or the Intercreditor Agreement.

          (e) Royalty Sub shall not liquidate or dissolve, consolidate with, or
     merge into or with, any other Person, or purchase or otherwise acquire all
     or substantially all of the assets of any Person (or any division thereof),
     or sell, convey, transfer, lease or otherwise dispose of Royalty Sub Rights
     or all or any material portion of its other property and

                                      -22-
<PAGE>
     assets to, any other Person, or permit any other Person to merge with or
     into, or consolidate or otherwise combine with, Royalty Sub.

          (f) Royalty Sub shall not, directly or indirectly, issue, deliver or
     sell, or consent to issue, deliver or sell, any actual, contingent, future
     or executory membership interests, beneficial interests, share capital or
     other equity or ownership interests or other Capital Securities (however
     designated, whether voting or non-voting), except for any additional
     Capital Securities of Royalty Sub issued to the Pledgor, provided that such
     additional Capital Securities are pledged to the Administrative Agent
     pursuant to the First Lien Pledge and Security Agreement and to the Trustee
     pursuant to the Second Lien Pledge and Security Agreement, and provided
     further that Royalty Sub shall not accept any capital contributions or
     other Investments from Quintiles or the Pledgor after the Closing Date
     except for contributions permitted by the Intercreditor Agreement.

          (g) Except as otherwise provided in the Memorandum of Association and
     the Articles of Association of Royalty Sub, as amended, restated,
     supplemented or otherwise modified from time to time in accordance with
     clause (a), Royalty Sub shall not engage in any business or activity other
     than purchasing, holding and pledging Royalty Sub Rights, collecting
     Royalty Sub Payments (as defined in the Indenture), incurring the
     Indebtedness and other obligations under the Second Lien Note Documents,
     entering into the Hedge Agreement, if any, on the Closing Date and
     remaining an Obligor under the Loan Documents and a party to the
     Transaction Documents.

          (h) Royalty Sub shall not, directly or indirectly, enter into, renew
     or extend any transaction (including the purchase, sale, lease or exchange
     of property or assets, or the rendering of any service) with any Affiliate
     of Royalty Sub, except for the Acquisition Documents as in effect on the
     date hereof.

          (i) Royalty Sub shall not take any action to become subject to a
     Voluntary Bankruptcy or Involuntary Bankruptcy. Royalty Sub shall provide
     promptly to the Administrative Agent written notice of the institution of
     any proceeding by or against Royalty Sub seeking to adjudicate it a
     bankrupt or insolvent, or seeking liquidation, winding-up, reorganization,
     arrangement, adjustment, protection, relief or composition of its debts
     under any law relating to bankruptcy, insolvency or reorganization or
     relief of debtors, or seeking the entry of an order for relief or the
     appointment of a receiver, Administrative Agent or other similar official
     for it or for any substantial part of its property. Royalty Sub shall not
     take any action to waive, repeal, amend, vary, supplement or otherwise
     modify its Organic Documents in a manner that would adversely affect (x)
     the rights, remedies, privileges or preferences of any Secured Party or (y)
     the Collateral (including the Royalty Sub Rights).

          (j) Royalty Sub shall duly and punctually pay the principal, premium,
     if any, and interest on the Loans, and all other Obligations, in accordance
     with the terms of this Agreement and the other Loan Documents; provided
     that, except in the case of the Stated Maturity Date or a Mandatory
     Repayment Date, Royalty Sub shall be in compliance with this covenant if it
     pays in full by the next succeeding Payment Date or Mandatory

                                      -23-
<PAGE>
     Repayment Date any interest on the Loans that became due and was not paid
     on any Payment Date (including interest thereon).

          (k) Royalty Sub shall not employ any employees other than as required
     by any provisions of local law; provided that the Service Providers and the
     directors and officers of Royalty Sub shall not be deemed to be employees
     for purposes of this clause (k).

          (l) Royalty Sub will not enter into any agreement prohibiting (i) the
     creation or assumption of any Lien upon its properties, revenues or assets,
     whether now owned or hereafter acquired or (ii) the ability of any Obligor
     to amend or otherwise modify any Loan Document. The foregoing prohibitions
     shall not apply to restrictions contained in any Loan Document or any
     Second Lien Note Document.

          (m) Royalty Sub shall at all times enforce its rights under the
     Purchase and Sale Agreement and the Servicing Agreement in a commercially
     reasonable manner.

          (n) Royalty Sub shall record any charge created by it in its register
     of mortgages and charges pursuant to Section 56 Companies Law (2004
     Revision) and make such register open to inspection by its members and the
     Secured Parties.

          (o) Royalty Sub shall maintain its existence separate and distinct
     from any other Person in all material respects, including taking the
     following actions as appropriate:

               (i) maintaining in full effect its existence, rights and
          franchises as an exempted company incorporated with limited liability
          under the laws of the Cayman Islands and obtaining and preserving its
          qualification to do business in each jurisdiction in which such
          qualification is or will be necessary to protect the validity and
          enforceability of this Agreement and each other Loan Document and each
          other instrument or agreement necessary or appropriate to properly
          administer this Agreement and each other Loan Document and permit and
          effectuate the transactions contemplated hereby and thereby;

               (ii) maintaining its own deposit accounts, separate from those of
          the Pledgor, Quintiles, any of its directors or officers and their
          respective Affiliates;

               (iii) conducting no material transactions between Royalty Sub and
          any of its Affiliates, other than entering into the Acquisition
          Documents;

               (iv) allocating fairly and reasonably the cost of any shared
          overhead expenses, including office space with the Pledgor, Quintiles,
          any of its directors or officers or any of their respective
          Affiliates;

               (v) conducting its affairs separately from those of the Pledgor,
          Quintiles, any of its directors or officers or any of their respective
          Affiliates (other than Royalty Sub) and maintaining accurate and
          separate books, records and accounts and financial statements,
          including in connection with the purchase of

                                      -24-
<PAGE>
          Royalty Sub Rights from the Pledgor; it being agreed that performance
          under the Loan Documents will not result in Royalty Sub's contravening
          this clause (v);

               (vi) acting solely in its own name and not that of any other
          Person, including the Pledgor, Quintiles, any of its directors or
          officers or any of their respective Affiliates, and at all times use
          its own stationery, invoices and checks separate from those of the
          Pledgor, Quintiles, any of its directors or officers or any of their
          respective Affiliates;

               (vii) not holding itself out as having agreed to pay or
          Guarantee, or as otherwise being liable for, the obligations of the
          Pledgor, Quintiles, any of its directors or officers or any of their
          respective Affiliates;

               (viii) insuring that any financial reports prepared by Royalty
          Sub disclose the effects of the true sale of Royalty Sub Rights by the
          Pledgor and any of its Affiliates in compliance with GAAP;

               (ix) maintaining all of its assets in its own name and not
          commingling its assets with those of any other Person except as
          required under the Intercreditor Agreement or any other Loan Document;

               (x) paying its own operating expenses and other liabilities out
          of its own funds;

               (xi) holding regular meetings of its directors, as appropriate,
          and observing all formalities required by the Organic Documents of
          Royalty Sub;

               (xii) maintaining adequate capital for the normal obligations
          reasonably foreseeable in light of its contemplated business
          operations;

               (xiii) not acquiring obligations of its shareholders, the
          Pledgor, Quintiles, any of its directors or officers or any of their
          respective Affiliates;

               (xiv) holding itself out to the public as a legal entity separate
          and distinct from any other Person, including Quintiles or the Pledgor
          or any Affiliate of Quintiles or the Pledgor (other than Royalty Sub);

               (xv) correcting any known misunderstanding regarding its separate
          identity;

               (xvi) not forming, acquiring or holding any Subsidiaries or other
          interests in the Capital Securities of any Person; and

               (xvii) not sharing any common logo with or identifying itself as
          a department or division of the Pledgor, Quintiles, any of its
          directors or officers or any of their respective Affiliates.

                                      -25-
<PAGE>
     SECTION 7.3. Covenants of Pledgor. Each of the covenants made by the
Pledgor in Sections 6.1 and 6.2 of the Purchase and Sale Agreement and by the
Pledgor in Article VI of the First Lien Pledge and Security Agreement, is hereby
incorporated herein by reference as if fully set forth herein and given for the
benefit of the Secured Parties. In furtherance of the foregoing, the Pledgor
will cause Royalty Sub to comply with the terms and provisions of this Agreement
and the other Loan Documents and the Acquisition Documents.

                                  ARTICLE VIII
                                EVENTS OF DEFAULT

     SECTION 8.1. Listing of Events of Default. Each of the following events or
occurrences described in this Article shall constitute an "Event of Default":

          (a) failure by Royalty Sub to pay the interest on the Loans due on any
     Payment Date (other than the Stated Maturity Date or a Mandatory Repayment
     Date) in full by the next succeeding Payment Date, together with interest
     on any interest not paid on the Payment Date on which it was originally
     due;

          (b) failure by Royalty Sub to pay when due principal and accrued and
     unpaid interest on any Loans on the Stated Maturity Date or a Mandatory
     Repayment Date;

          (c) failure by Royalty Sub to pay any Obligation (other than principal
     and interest) when due and payable in connection with the Loan Documents,
     and the continuance of such default for a period of five Business Days or
     more after written notice thereof is given to Royalty Sub by the
     Administrative Agent;

          (d) any representation or warranty of any Obligor made or deemed to be
     made in any Loan Document (including any certificates delivered pursuant to
     Article V) is or shall be materially incorrect when made or deemed to have
     been made;

          (e) a default shall occur in the payment of any amount when due
     (subject to any applicable grace period), whether by acceleration,
     mandatory repayment or redemption, or otherwise, of any principal or stated
     amount of, or interest or fees on, any Indebtedness (other than
     Indebtedness described in clause (a), (b) or (c)) of any Obligor having a
     principal or stated amount, individually or in the aggregate, in excess of
     $1,000,000, or a default shall occur in the performance or observance of
     any obligation or condition with respect to such Indebtedness if the effect
     of such default is to accelerate the maturity of any such Indebtedness or
     such default shall continue unremedied for any applicable period of time
     sufficient to permit the holder or holders of such Indebtedness, or any
     trustee or agent for such holders, to cause or declare such Indebtedness to
     become due and payable or to require such Indebtedness to be prepaid,
     redeemed, purchased or defeased, or require an offer to purchase or defease
     such Indebtedness to be made, or to exercise remedies in respect of any
     collateral securing such Indebtedness, prior to its expressed maturity;

          (f) (i) failure by Royalty Sub to comply in any material respect with
     any of the covenants set forth in clauses (a), (b) or (c) of Section 7.1.1,
     Section 7.1.4 or Section 7.2 (other than clause (j), (n) or (o) thereof),
     and written notice thereof being given to

                                      -26-
<PAGE>
     Royalty Sub by the Administrative Agent at the written direction of the
     Required Lenders; or (ii) failure by any Obligor to comply in any material
     respect with any of the other covenants, obligations, conditions or
     provisions binding on it under any Loan Document (other than a payment
     default for which provision is made in clause (a), (b) or (c) above) if (in
     the case of this clause (ii) only) such failure continues for a period of
     30 days or more after written notice thereof has been given to Royalty Sub
     by the Administrative Agent at the written direction of the Required
     Lenders;

          (g) the occurrence of a Voluntary Bankruptcy or an Involuntary
     Bankruptcy;

          (h) any judgment or order for the payment of money in excess of
     U.S.$1,000,000 shall be rendered against Royalty Sub and either (i)
     enforcement proceedings have been commenced by any creditor upon such
     judgment or order or (ii) there is any period of ten consecutive days
     during which a stay of enforcement of such judgment or order, by reason of
     a pending appeal or otherwise, shall not be in effect;

          (i) Quintiles or the Pledgor shall have failed to perform in any
     material respect any of its respective covenants under the Purchase and
     Sale Agreement; or

          (j) the Pledgor shall have failed to perform in any material respect
     any of its covenants of the First Lien Pledge and Security Agreement.

     SECTION 8.2. Termination of Commitments. If any Event of Default described
in clause (g) of Section 8.1 with respect to Royalty Sub shall occur, the
Commitments (if not theretofore terminated) shall automatically terminate. If
any Event of Default (other than any Event of Default described in clause (g) of
Section 8.1) shall occur for any reason, whether voluntary or involuntary, and
be continuing, the Administrative Agent, upon the direction of the Required
Lenders, shall by notice to Royalty Sub declare all or any portion of the
Commitments (if not theretofore terminated) to be terminated, whereupon the
Commitments shall terminate.

     SECTION 8.3. Remedies.

     SECTION 8.3.1. Remedies. Upon the occurrence and continuation of an Event
of Default, neither the Administrative Agent nor any other Secured Party shall
have the right to accelerate the outstanding principal amount of the Loans.
Subject to the provisions of the Intercreditor Agreement, if any Event of
Default shall have occurred and be continuing, the Administrative Agent may at
all times pursue any available remedy against any Obligor by proceeding at law
or in equity to collect the payment of principal of, premium, if any, or
interest on the Loans and other Obligations or to enforce the performance of any
provision of the Loan Documents to the fullest extent permitted by law.

     (a) The Administrative Agent may obtain the appointment of a receiver of
the Collateral or any part thereof and for any other order in relation to the
administration of this Agreement or any other Loan Document, and it may assent
to or approve any application to any court of competent jurisdiction and shall
be indemnified by Royalty Sub against all costs, charges and expenses incurred
by in relation to any such application or proceedings.

                                      -27-
<PAGE>
     (b) The Administrative Agent may, without notice to Royalty Sub and at such
time as the Administrative Agent in its sole discretion may determine, exercise
any or all of Royalty Sub's rights in, to and under or in any way connected with
or related to any or all of the Collateral, including (i) demanding and
enforcing payment and performance of, and exercising any or all of Royalty Sub's
rights and remedies with respect to the collection, enforcement or prosecution
of, any or all of the Collateral (including the Royalty Sub Rights and Royalty
Sub's rights under the Purchase and Sale Agreement), in each case by legal
proceedings or otherwise, (ii) settling, adjusting, compromising, extending,
renewing, discharging and releasing any or all of, and any legal proceedings
brought to collect or enforce any or all of, Royalty Sub Rights and otherwise
under the Transaction Documents and (iii) preparing, filing and signing the name
of Royalty Sub on (A) any proof of claim or similar document to be filed in any
bankruptcy or similar proceeding involving the Collateral (including Royalty Sub
Rights) and (B) any notice of lien, assignment or satisfaction of lien, or
similar document in connection with the Collateral (including Royalty Sub
Rights).

     (c) The Administrative Agent may, without notice except as specified
herein, sell or cause the sale of all or any part of the Collateral in one or
more parcels at public or private sale, at any of the Administrative Agent's
offices or elsewhere, for cash, on credit or for future delivery, and upon such
other terms as the Administrative Agent may deem commercially reasonable,
provided that, so long as the Co-Promotion Agreement has not been terminated,
the Administrative Agent shall make any such sale only to Quintiles, Lilly,
Royalty Sub or one of their respective Affiliates, or to a Person that (i) has
provided a confidentiality agreement to Royalty Sub (whether in the form of
Exhibit H, in the form to be signed by Permitted Holders (as defined in the
Indenture) (in either case with the necessary changes being made to reflect
identity of the parties and the nature of the transaction) or in a form
otherwise satisfactory to Royalty Sub) and (ii) has represented and warranted
that such Person and each Affiliate thereof is not in the business of
developing, manufacturing or marketing pharmaceutical or diagnostic products.
Royalty Sub agrees that, to the extent notice of sale shall be required by law,
at least ten days' notice to Royalty Sub of the time and place of any public
sale or the time after which any private sale is to be made shall constitute
reasonable notification. The Administrative Agent shall not be obligated to make
any sale of all or any part of the Collateral regardless of notice of sale
having been given. The Administrative Agent may adjourn any public or private
sale from time to time by announcement at the time and place fixed therefor, and
such sale may, without further notice, be made at the time and place to which it
was so adjourned.

     (d) The Administrative Agent may, instead of exercising the power of sale
conferred upon it by clause (c), proceed by a suit or suits at law or in equity
to foreclose the Lien and sell all or any portion of the Collateral under a
judgment or a decree of a court or courts of competent jurisdiction, provided
that, so long as the Co-Promotion Agreement has not been terminated, the
Administrative Agent shall make any such foreclosure sale only to Quintiles,
Lilly, Royalty Sub or one of their Affiliates or to a Person that (i) has
provided a confidentiality agreement to Royalty Sub (whether in the form of
Exhibit H, in the form to be signed by Permitted Holders (as defined in the
Indenture) (in either case with the necessary changes being made to reflect
identity of the parties and the nature of the transaction) or in a form
otherwise satisfactory to Royalty Sub) and (ii) has represented and warranted
that such Person and each Affiliate thereof is not in the business of
developing, manufacturing or marketing pharmaceutical or diagnostic products.

                                      -28-
<PAGE>
     (e) The Administrative Agent may require Royalty Sub to, and Royalty Sub
hereby agrees that it shall at its expense and upon request of the
Administrative Agent, forthwith assemble all or part of the Collateral as
directed by the Administrative Agent and make it available to the Administrative
Agent at a place to be designated by the Administrative Agent that is reasonably
convenient to both parties.

     (f) In addition to the rights and remedies provided for in this Indenture,
the Administrative Agent may exercise in respect of the Collateral all the
rights and remedies of a secured party upon default under the UCC (whether or
not the UCC applies to the affected property included in the Collateral) and
under all other applicable laws; provided that, so long as the Co-Promotion
Agreement has not been terminated, the Administrative Agent shall cause any sale
of the Collateral to be made only to Quintiles, Lilly, Royalty Sub or one of
their respective Affiliates, or to a Person that (i) has provided a
confidentiality agreement to Royalty Sub (whether in the form of Exhibit H, in
the form to be signed by Permitted Holders (as defined in the Indenture) (in
either case with the necessary changes being made to reflect identity of the
parties and the nature of the transaction) or in a form otherwise satisfactory
to Royalty Sub) and (ii) has represented and warranted that such Person and each
Affiliate thereof is not in the business of developing, manufacturing or
marketing pharmaceutical or diagnostic products.

     SECTION 8.3.2. Restoration of Royalty Sub Rights and Remedies. If the
Administrative Agent or any other Secured Party has instituted any proceeding to
enforce any right or remedy under this Agreement or any other Loan Document, and
such proceeding has been discontinued or abandoned for any reason or has been
determined adversely to the Administrative Agent or such other Secured Party,
then in every such case Royalty Sub, the Administrative Agent and the other
Secured Parties shall, subject to any determination in such proceeding, be
restored severally and respectively to their former positions hereunder, and
thereafter all rights and remedies of the Administrative Agent and the other
Secured Parties shall continue as though no such proceeding had been instituted.

     SECTION 8.3.3. Remedies Cumulative. Each and every right, power and remedy
herein given to the Administrative Agent specifically or otherwise shall be
cumulative and shall, to the extent permitted by law, be in addition to every
other right, power and remedy herein specifically given or now or hereafter
existing at law, in equity or by statute, and each and every right, power and
remedy whether specifically herein given or otherwise existing may be exercised
from time to time and as often and in such order as may be deemed expedient by
the Administrative Agent, and the exercise or the beginning of the exercise of
any power or remedy shall not be construed to be a waiver of the right to
exercise at the same time or thereafter any other right, power or remedy. No
delay or omission by the Administrative Agent in the exercise of any right,
remedy or power or in the pursuance of any remedy shall impair any such right,
power or remedy or be construed to be a waiver of any Default on the part of
Royalty Sub or to be an acquiescence.

     SECTION 8.3.4. Authority of Courts Not Required. The parties hereto agree
that, to the greatest extent permitted by law, the Administrative Agent shall
not be obliged or required to seek or obtain the authority of, or any judgment
or order of, the courts of any jurisdiction in order to exercise any of its
rights, powers and remedies under this Agreement or any other Loan Document, and
the parties hereby waive any such requirement to the greatest extent permitted
by law.

                                      -29-
<PAGE>
     SECTION 8.3.5. Administrative Agent May File Proofs of Claim. The
Administrative Agent may file such proofs of claim and other papers or documents
as may be necessary or advisable in order to have the claims of any Secured
Party allowed in any judicial proceedings relating to any Obligor or the
Collateral. Upon the occurrence of an event that, given the passage of time,
would constitute an Involuntary Bankruptcy, Royalty Sub hereby expressly
authorizes each Secured Party to appear in any court conducting any relevant
proceeding during such time period to preserve, protect and defend their rights
under the Loan Documents.

     SECTION 8.3.6. Application of Proceeds. All cash proceeds received by the
Administrative Agent in respect of any sale of, collection from or other
realization upon all or any part of the Collateral shall be deposited in the
Collection Account and distributed as provided in the Intercreditor Agreement.

     SECTION 8.3.7. Waivers of Royalty Sub Rights Inhibiting Enforcement.
Royalty Sub waives (a) any claim that, as to any part of the Collateral, a
public sale, should the Administrative Agent elect so to proceed, is, in and of
itself, not a commercially reasonable method of sale for such part of the
Collateral, (b) the right to assert in any action or proceeding between it and
the Administrative Agent offsets or counterclaims that it may have, (c) except
as otherwise provided in any of the Loan Documents, TO THE EXTENT PERMITTED BY
APPLICABLE LAW, NOTICE OR JUDICIAL HEARING IN CONNECTION WITH THE ADMINISTRATIVE
AGENT'S TAKING POSSESSION OR DISPOSITION OF ANY OF THE COLLATERAL, INCLUDING ANY
AND ALL PRIOR NOTICE AND HEARING FOR ANY PREJUDGMENT REMEDY OR REMEDIES AND ANY
SUCH RIGHT THAT ROYALTY SUB WOULD OTHERWISE HAVE UNDER THE CONSTITUTION OR ANY
STATUTE OF THE U.S. OR OF ANY STATE, AND ALL OTHER REQUIREMENTS AS TO THE TIME,
PLACE AND TERMS OF SALE OR OTHER REQUIREMENTS WITH RESPECT TO THE ENFORCEMENT OF
THE ADMINISTRATIVE AGENT'S RIGHTS HEREUNDER, (d) all rights of redemption,
appraisement, valuation, stay and extension or moratorium and (e) except as
otherwise provided in any of the Loan Documents, all other rights the exercise
of which would, directly or indirectly, prevent, delay or inhibit the
enforcement of any of the rights or remedies under this Agreement or the
absolute sale of the Collateral, now or hereafter in force under any applicable
law, and Royalty Sub, for itself and all who may claim under it, insofar as it
or they now or hereafter lawfully may, hereby waives the benefit of all such
laws and rights.

                                   ARTICLE IX
                                   THE AGENTS

     SECTION 9.1. Actions. Each Lender hereby appoints MS as its Administrative
Agent and Syndication Agent under and for purposes of each Loan Document. Each
Lender authorizes the Administrative Agent to act on behalf of such Lender under
each Loan Document and, in the absence of other written instructions from the
Required Lenders received from time to time by the Administrative Agent (with
respect to which the Administrative Agent agrees that it will comply, except as
otherwise provided in this Section or as otherwise advised by counsel in order
to avoid contravention of applicable law), to exercise such powers hereunder and
thereunder as are specifically delegated to or required of the Administrative
Agent by the terms hereof and thereof, together with such powers as may be
incidental thereto (including the release of Liens on

                                      -30-
<PAGE>
assets disposed of in accordance with the terms of the Loan Documents). Each
Lender hereby indemnifies (which indemnity shall survive any termination of this
Agreement) the Agents, pro rata according to such Lender's proportionate Total
Exposure Amount, from and against any and all liabilities, obligations, losses,
damages, claims, costs or expenses of any kind or nature whatsoever which may at
any time be imposed on, incurred by, or asserted against, the Agents in any way
relating to or arising out of any Loan Document (including attorneys' fees), and
as to which such Agent is not reimbursed by Royalty Sub; provided that no Lender
shall be liable for the payment of any portion of such liabilities, obligations,
losses, damages, claims, costs or expenses which are determined by a court of
competent jurisdiction in a final proceeding to have resulted from such Agent's
gross negligence or willful misconduct. No Agents shall be required to take any
action under any Loan Document, or to prosecute or defend any suit in respect of
any Loan Document, unless it is indemnified hereunder to its satisfaction. If
any indemnity in favor of any Agent shall be or become, in the Agent's
determination, inadequate, such Agent may call for additional indemnification
from the Lenders and cease to do the acts indemnified against hereunder until
such additional indemnity is given.

     SECTION 9.2. Funding Reliance, etc. Unless the Administrative Agent shall
have been notified in writing by any Lender by 3:00 p.m. on the Business Day
prior to a Borrowing that such Lender will not make available the amount which
would constitute its Percentage of such Borrowing on the date specified
therefor, the Administrative Agent may assume that such Lender has made such
amount available to the Administrative Agent and, in reliance upon such
assumption, make available to Royalty Sub a corresponding amount. If and to the
extent that such Lender shall not have made such amount available to the
Administrative Agent, such Lender and Royalty Sub severally agree to repay the
Administrative Agent forthwith on demand such corresponding amount together with
interest thereon, for each day from the date the Administrative Agent made such
amount available to Royalty Sub to the date such amount is repaid to the
Administrative Agent, at the interest rate applicable at the time to Loans
comprising such Borrowing (in the case of Royalty Sub) and (in the case of a
Lender), at the Federal Funds Rate (for the first two Business Days after which
such amount has not been repaid), and thereafter at the interest rate applicable
to Loans comprising such Borrowing.

     SECTION 9.3. Exculpation. None of the Agents nor any of their respective
directors, officers, employees or agents shall be liable to any Secured Party
for any action taken or omitted to be taken by it under any Loan Document, or in
connection therewith, except for its own willful misconduct or gross negligence,
nor responsible for any recitals or warranties herein or therein, nor for the
effectiveness, enforceability, validity or due execution of any Loan Document,
nor for the creation, perfection or priority of any Liens purported to be
created by any of the Loan Documents, or the validity, genuineness,
enforceability, existence, value or sufficiency of any collateral security, nor
to make any inquiry respecting the performance by any Obligor of its
Obligations. Any such inquiry which may be made by any Agent shall not obligate
it to make any further inquiry or to take any action. Each Agent shall be
entitled to rely upon advice of counsel concerning legal matters and upon any
notice, consent, certificate, statement or writing which such Agent believes to
be genuine and to have been presented by a proper Person.

     SECTION 9.4. Successor. The Administrative Agent may resign as such at any
time upon at least 30 days' prior notice to Royalty Sub and all Lenders. If the
Administrative Agent

                                      -31-
<PAGE>
at any time shall resign, the Required Lenders may appoint another Lender that
has executed and delivered a Confidentiality Agreement as a successor
Administrative Agent which shall thereupon become the Administrative Agent
hereunder. If no successor Administrative Agent shall have been so appointed by
the Required Lenders, and shall have accepted such appointment, within 30 days
after the retiring Administrative Agent's giving notice of resignation, then the
retiring Administrative Agent may, on behalf of the Lenders, appoint a successor
Administrative Agent, which shall be one of the Lenders or a commercial banking
institution organized under the laws of the United States (or any State thereof)
or a United States branch or agency of a commercial banking institution, and
having a combined capital and surplus of at least $250,000,000, and shall have
executed and delivered a Confidentiality Agreement; provided that if such
retiring Administrative Agent is unable to find a commercial banking institution
which is willing to accept such appointment and which meets the qualifications
set forth in above, the retiring Administrative Agent's resignation shall
nevertheless thereupon become effective and the Lenders shall assume and perform
all of the duties of the Administrative Agent hereunder until such time, if any,
as the Required Lenders appoint a successor as provided for above. Upon the
acceptance of any appointment as Administrative Agent hereunder by a successor
Administrative Agent, such successor Administrative Agent shall be entitled to
receive from the retiring Administrative Agent such documents of transfer and
assignment as such successor Administrative Agent may reasonably request, and
shall thereupon succeed to and become vested with all rights, powers, privileges
and duties of the retiring Administrative Agent, and the retiring Administrative
Agent shall be discharged from its duties and obligations under the Loan
Documents. After any retiring Administrative Agent's resignation hereunder as
the Administrative Agent, the provisions of this Article shall inure to its
benefit as to any actions taken or omitted to be taken by it while it was the
Administrative Agent under the Loan Documents, and Section 10.3 and Section 10.4
shall continue to inure to its benefit. The Syndication Agent may resign as such
at any time upon at least 10 days' prior notice to Royalty Sub, all Lenders and
the other Agents.

     SECTION 9.5. Loans by MS. MS shall have the same rights and powers with
respect to (x) the Loans made by it or any of its Affiliates, and (y) the Notes
held by it or any of its Affiliates as any other Lender and may exercise the
same as if it were not the Administrative Agent. MS and its Affiliates may
accept deposits from, lend money to, and generally engage in any kind of
business with Royalty Sub or any Subsidiary or Affiliate of Royalty Sub as if MS
were not an Agent hereunder.

     SECTION 9.6. Credit Decisions. Each Lender acknowledges that it has,
independently of the Agents and each other Lender, and based on such Lender's
review of the financial information of Royalty Sub, the Loan Documents (the
terms and provisions of which being satisfactory to such Lender) and such other
documents, information and investigations as such Lender has deemed appropriate,
made its own credit decision to extend its Commitments. Each Lender also
acknowledges that it will, independently of the Agents and each other Lender,
and based on such other documents, information and investigations as it shall
deem appropriate at any time, continue to make its own credit decisions as to
exercising or not exercising from time to time any rights and privileges
available to it under the Loan Documents.

     SECTION 9.7. Copies, etc. The Administrative Agent shall give prompt notice
to each Lender that has executed and delivered a Confidentiality Agreement of
each notice or request

                                      -32-
<PAGE>
required or permitted to be given to the Administrative Agent by Royalty Sub
pursuant to the terms of the Loan Documents (unless concurrently delivered to
the Lenders by Royalty Sub) and each other notice received from Quintiles or
Lilly relating to the Transaction. The Administrative Agent will distribute to
each such Lender each document or instrument received for its account (including
each Distribution Report received by the Administrative Agent for the benefit of
such Lenders) and copies of all other communications received by the
Administrative Agent from Royalty Sub for distribution to such Lenders by the
Administrative Agent in accordance with the terms of the Loan Documents.

     SECTION 9.8. Reliance by Administrative Agents. The Agents shall be
entitled to rely upon any certification, notice or other communication
(including any thereof by telephone, telecopy, telegram or cable) believed by it
to be genuine and correct and to have been signed or sent by or on behalf of the
proper Person, and upon advice and statements of legal counsel, independent
accountants and other experts selected by any Agent. As to any matters not
expressly provided for by the Loan Documents, the Agents shall in all cases be
fully protected in acting, or in refraining from acting, thereunder in
accordance with instructions given by the Required Lenders or all of the Lenders
as is required in such circumstance, and such instructions of such Lenders and
any action taken or failure to act pursuant thereto shall be binding on all
Secured Parties.

     SECTION 9.9. Defaults. The Agents shall not be deemed to have knowledge or
notice of the occurrence of a Default unless the Administrative Agent has
received a written notice from a Lender or Royalty Sub specifying such Default
and stating that such notice is a "Notice of Default". In the event that the
Administrative Agent receives such a notice of the occurrence of a Default, the
Administrative Agent shall give prompt notice thereof to the Lenders. Subject to
the provisions of the Intercreditor Agreement, the Administrative Agent shall
(subject to Section 10.1) take such action with respect to such Default as shall
be directed by the Required Lenders; provided that unless and until the
Administrative Agent shall have received such directions, the Administrative
Agent may (but shall not be obligated to) take such action, or refrain from
taking such action, with respect to such Default as it shall deem advisable in
the best interest of the Secured Parties except to the extent that this
Agreement expressly requires that such action be taken, or not be taken, only
with the consent or upon the authorization of the Required Lenders or all
Lenders.

                                    ARTICLE X
                            MISCELLANEOUS PROVISIONS

     SECTION 10.1. Waivers, Amendments, etc. The provisions of each Loan
Document may from time to time be amended, modified or waived, if such
amendment, modification or waiver is in writing and consented to by Royalty Sub
and the Required Lenders; provided that no such amendment, modification or
waiver shall:

          (a) modify this Section or change or waive any provision of Section
     4.7 or 4.8 requiring pro rata treatment of the Lenders, or the sharing of
     payments by all Lenders, in each case, without the consent of all Lenders;

                                      -33-
<PAGE>
          (b) increase the aggregate amount of any Loans required to be made by
     a Lender pursuant to its Commitments, extend the final Commitment
     Termination Date of Loans made (or participated in) by a Lender or extend
     the final Stated Maturity Date for any Lender's Loan, in each case without
     the consent of such Lender;

          (c) reduce (by way of forgiveness) the principal amount of or reduce
     the rate of interest on any Lender's Loan, reduce any fees described in
     Article III payable to any Lender or extend the date on which interest or
     fees are payable in respect of such Lender's Loans, in each case without
     the consent of such Lender (provided that the vote of Required Lenders
     shall be sufficient to waive the payment, or reduce the increased portion,
     of interest accruing under Section 3.2.2);

          (d) reduce the percentage set forth in the definition of "Required
     Lenders" or modify any requirement hereunder that any particular action be
     taken by all Lenders without the consent of all Lenders;

          (e) except as otherwise expressly provided in a Loan Document, release
     Royalty Sub from its Obligations under the Loan Documents or the Pledgor
     from its obligations under the First Lien Pledge and Security Agreement or
     all or substantially all of the collateral under the Loan Documents, in
     each case without the consent of all Lenders;

          (f) change Section 3 of the Intercreditor Agreement without the
     consent of all Lenders; or

          (g) affect adversely the interests, rights or obligations of the
     Administrative Agent (in its capacity as the Administrative Agent), unless
     consented to by the Administrative Agent.

No failure or delay on the part of any Secured Party in exercising any power or
right under any Loan Document shall operate as a waiver thereof, nor shall any
single or partial exercise of any such power or right preclude any other or
further exercise thereof or the exercise of any other power or right. No notice
to or demand on any Obligor in any case shall entitle it to any notice or demand
in similar or other circumstances. No waiver or approval by any Secured Party
under any Loan Document shall, except as may be otherwise stated in such waiver
or approval, be applicable to subsequent transactions. No waiver or approval
hereunder shall require any similar or dissimilar waiver or approval thereafter
to be granted hereunder.

     SECTION 10.2. Notices; Time. All notices and other communications provided
under each Loan Document shall be in writing (or by facsimile) and addressed,
delivered or transmitted, if to Royalty Sub, the Administrative Agent or a
Lender to the applicable Person at its address or facsimile number set forth
below each party's signature to this Agreement or set forth on Schedule I hereto
or set forth in the Lender Assignment Agreement, or at such other address or
facsimile number as may be designated by such party in a notice to the other
parties. Any notice, if mailed and properly addressed with postage prepaid or if
properly addressed and sent by pre-paid courier service, shall be deemed given
when received; any notice, if transmitted by facsimile, shall be deemed given
when the confirmation of transmission thereof is received by

                                      -34-
<PAGE>
the transmitter. Electronic mail and Internet and intranet websites may be used
only to distribute routine communications by the Administrative Agent to the
Lenders, such as information as provided in Section 7.1 and for the distribution
and execution of Loan Documents for execution by the parties thereto, and may
not be used for any other purpose. The parties hereto agree that delivery of an
executed counterpart of a signature page to this Agreement and each other Loan
Document by facsimile or other electronic communication shall be effective as
delivery of an original executed counterpart of this Agreement or such other
Loan Document. Unless otherwise indicated, all references to the time of a day
in a Loan Document shall refer to New York time.

     SECTION 10.3. Payment of Costs and Expenses. Royalty Sub agrees to pay all
expenses of the Administrative Agent (including the fees and out-of-pocket
expenses of Mayer, Brown, Rowe & Maw LLP, counsel to the Administrative Agent
and of local counsel, if any, who may be retained by or on behalf of the
Administrative Agent) in connection with

          (a) the negotiation, preparation, execution and delivery of each Loan
     Document, including schedules and exhibits, and any amendments, waivers,
     consents, supplements or other modifications to any Loan Document as may
     from time to time hereafter be required, whether or not the transactions
     contemplated hereby are consummated; and

          (b) the filing or recording of any Loan Document (including the Filing
     Statements) and all amendments, supplements, amendment and restatements and
     other modifications to any thereof, searches made following the Effective
     Date in jurisdictions where Filing Statements (or other documents
     evidencing Liens in favor of the Secured Parties) have been recorded and
     any and all other documents or instruments of further assurance required to
     be filed or recorded by the terms of any Loan Document; and

          (c) the preparation and review of the form of any document or
     instrument relevant to any Loan Document.

Royalty Sub further agrees to pay, and to save each Secured Party harmless from
all liability for, any stamp or other taxes which may be payable in connection
with the execution or delivery of each Loan Document, the Loans or the issuance
of the Notes. Royalty Sub also agrees to reimburse the Administrative Agent upon
demand for all reasonable out-of-pocket expenses (including reasonable
attorneys' fees and legal expenses of counsel to the Administrative Agent)
incurred by the Administrative Agent, and to reimburse the reasonable attorneys'
fees and legal expenses of counsel to each Lender that, together with its
Affiliates, holds more than 35% of the Total Exposure Amount, in each case in
connection with (x) activities by the Administrative Agent and each such counsel
during the continuance of an Event of Default, (y) the negotiation of any
restructuring or "work-out" with Royalty Sub, whether or not consummated, of any
Obligations and (z) the enforcement of any Obligations.

     SECTION 10.4. Indemnification. In consideration of the execution and
delivery of this Agreement by each Secured Party, Royalty Sub hereby indemnifies
and holds each Secured Party and each of their respective officers, directors,
employees, agents, trustees and advisors (collectively, the "Indemnified
Parties") harmless from and against any and all actions, causes of action,
suits, losses, costs, liabilities and damages, and expenses incurred in
connection therewith

                                      -35-
<PAGE>
(irrespective of whether any such Indemnified Party is a party to the action for
which indemnification hereunder is sought), including reasonable attorneys' fees
and disbursements, whether incurred in connection with actions between or among
the parties hereto or the parties hereto and third parties (collectively, the
"Indemnified Liabilities"), incurred by the Indemnified Parties or any of them
as a result of, or arising out of, or relating to

          (a) any transaction financed or to be financed in whole or in part,
     directly or indirectly, with the proceeds of any Loan, including all
     Indemnified Liabilities arising in connection with the Transaction;

          (b) the entering into and performance of any Loan Document by any of
     the Indemnified Parties (including any action brought by or on behalf of
     Royalty Sub as the result of any determination by the Required Lenders
     pursuant to Article V not to fund any Loan, provided that any such action
     is resolved in favor of such Indemnified Party);

          (c) any investigation, litigation or proceeding related to any
     acquisition or proposed acquisition by any Obligor or any Subsidiary
     thereof of all or any portion of the Capital Securities or assets of any
     Person, whether or not an Indemnified Party is party thereto; or

          (d) each Lender's Environmental Liability (the indemnification herein
     shall survive repayment of the Obligations and any transfer of the property
     of any Obligor or its Subsidiaries by foreclosure or by a deed in lieu of
     foreclosure for any Lender's Environmental Liability, regardless of whether
     caused by, or within the control of, such Obligor or such Subsidiary);

except for Indemnified Liabilities arising for the account of a particular
Indemnified Party by reason of the relevant Indemnified Party's gross negligence
or willful misconduct. Each Obligor and its successors and assigns hereby waive,
release and agree not to make any claim or bring any cost recovery action
against, any Indemnified Party under CERCLA or any state equivalent, or any
similar law now existing or hereafter enacted. It is expressly understood and
agreed that to the extent that any Indemnified Party is strictly liable under
any Environmental Laws, each Obligor's obligation to such Indemnified Party
under this indemnity shall likewise be without regard to fault on the part of
any Obligor with respect to the violation or condition which results in
liability of an Indemnified Party. If and to the extent that the foregoing
undertaking may be unenforceable for any reason, each Obligor agrees to make the
maximum contribution to the payment and satisfaction of each of the Indemnified
Liabilities which is permissible under applicable law.

     SECTION 10.5. Survival. The obligations of Royalty Sub under Sections 4.3,
4.4, 4.5, 4.6, 10.3 and 10.4, and the obligations of the Lenders under Section
9.1, shall in each case survive any assignment from one Lender to another (in
the case of Sections 10.3 and 10.4) and the occurrence of the Termination Date.
The representations and warranties made by each Obligor in each Loan Document
shall survive the execution and delivery of such Loan Document.

                                      -36-
<PAGE>
     SECTION 10.6. Severability. Any provision of any Loan Document which is
prohibited or unenforceable in any jurisdiction shall, as to such provision and
such jurisdiction, be ineffective to the extent of such prohibition or
unenforceability without invalidating the remaining provisions of such Loan
Document or affecting the validity or enforceability of such provision in any
other jurisdiction.

     SECTION 10.7. Headings. The various headings of each Loan Document are
inserted for convenience only and shall not affect the meaning or interpretation
of such Loan Document or any provisions thereof.

     SECTION 10.8. Execution in Counterparts, Effectiveness, etc. This Agreement
may be executed by the parties hereto in several counterparts, each of which
shall be an original and all of which shall constitute together but one and the
same agreement. This Agreement shall become effective when counterparts hereof
executed on behalf of Royalty Sub, the Administrative Agent and each Lender (or
notice thereof satisfactory to the Administrative Agent), shall have been
received by the Administrative Agent.

     SECTION 10.9. Governing Law; Entire Agreement. EACH LOAN DOCUMENT (EXCEPT
AS OTHERWISE EXPRESSLY SET FORTH IN A LOAN DOCUMENT) WILL EACH BE DEEMED TO BE A
CONTRACT MADE UNDER AND GOVERNED BY THE INTERNAL LAWS OF THE STATE OF NEW YORK
(INCLUDING FOR SUCH PURPOSE SECTIONS 5-1401 AND 5-1402 OF THE GENERAL
OBLIGATIONS LAW OF THE STATE OF NEW YORK). The Loan Documents constitute the
entire understanding among the parties hereto with respect to the subject matter
thereof and supersede any prior agreements, written or oral, with respect
thereto.

     SECTION 10.10. Successors and Assigns. This Agreement shall be binding upon
and shall inure to the benefit of the parties hereto and their respective
successors and assigns; provided that Royalty Sub may not assign or transfer its
rights or obligations hereunder without the consent of all Lenders.

     SECTION 10.11. Sale and Transfer of Loans; Participations in Loans; Notes.
Each Lender may assign, or sell participations in, its Loans and Commitments to
one or more other Persons in accordance with the terms set forth below.

     (a) Any Lender may assign to one or more Eligible Assignees all or a
portion of its rights and obligations under the Loan Documents (including all or
a portion of its Commitments and the Loans at the time owing to it); provided
that:

          (i) except in the case of (A) an assignment of the entire remaining
     amount of the assigning Lender's Commitments and the Loans at the time
     owing to it or (B) an assignment to a Lender, an Affiliate of a Lender or
     an Approved Fund with respect to a Lender, the aggregate amount of the
     Commitments (which for this purpose includes Loans outstanding thereunder)
     or principal outstanding balance of the Loans of the assigning Lender
     subject to each such assignment (determined as of the date the Lender
     Assignment Agreement with respect to such assignment is delivered to the
     Administrative Agent) shall not be less than $1,000,000 and shall be in
     increments of

                                      -37-
<PAGE>
     $1,000,000 (unless the entire amount of Loans or Commitments of such
     assigning Lender is being assigned), unless the Administrative Agent
     otherwise consents;

          (ii) each partial assignment shall be made as an assignment of a
     proportionate part of all the assigning Lender's rights and obligations
     under this Agreement with respect to the Loans and/or the Commitments
     assigned, except that this clause (a) (ii) shall not prohibit any Lender
     from assigning all or a portion of its rights and obligations among
     separate tranches on a non-pro rata basis; and

          (iii) the parties to each assignment shall (A) either (1)
     electronically execute and deliver to the Administrative Agent a Lender
     Assignment Agreement via an electronic settlement system acceptable to the
     Administrative Agent (which initially shall be ClearPar, LLC) or (2)
     execute and deliver to the Administrative Agent a Lender Assignment
     Agreement and (B) (in the case of the Eligible Assignee) (1) execute and
     deliver a Confidentiality Agreement to the Administrative Agent (to the
     extent not previously provided by such Lender or one of its Affiliates) and
     (2) if the Eligible Assignee is not already a Lender, provide to the
     Administrative Agent administrative details with respect to such Eligible
     Assignee and applicable tax forms.

     (b) Subject to acceptance and recording thereof by the Administrative Agent
pursuant to clause (c), from and after the effective date specified in each
Lender Assignment Agreement, (i) the Eligible Assignee thereunder shall (if not
already a Lender) be a party hereto and, to the extent of the interest assigned
by such Lender Assignment Agreement, have the rights and obligations of a Lender
under the Loan Documents, and (ii) the assigning Lender thereunder shall
(subject to Section 10.5) be released from its obligations under the Loan
Documents, to the extent of the interest assigned by such Lender Assignment
Agreement (and, in the case of a Lender Assignment Agreement covering all of the
assigning Lender's rights and obligations under the Loan Documents, such Lender
shall cease to be a party hereto, but shall (as to matters arising prior to the
effectiveness of the Lender Assignment Agreement) continue to be entitled to the
benefits of any provisions of the Loan Documents which by their terms survive
the termination of this Agreement). Any assignment or transfer by a Lender of
rights or obligations under this Agreement that does not comply with the terms
of this Section shall be treated for purposes of the Loan Documents as a sale by
such Lender of a participation in such rights and obligations in accordance with
clause (d).

     (c) The Administrative Agent shall record each assignment made in
accordance with this Section in the Register pursuant to clause (a) of Section
2.5. The Register shall be available for inspection by Royalty Sub and any
Lender, at any reasonable time upon reasonable prior notice to the
Administrative Agent.

     (d) Any Lender may, without the consent of, or notice to, any Person, sell
participations to one or more Persons (other than individuals) (a "Participant")
in all or a portion of such Lender's rights or obligations under the Loan
Documents (including all or a portion of its Commitments or the Loans owing to
it); provided that (i) such Lender's obligations under the Loan Documents shall
remain unchanged, (ii) such Lender shall remain solely responsible to the other
parties hereto for the performance of such obligations, (iii) Royalty Sub, the
Administrative Agent and the other Lenders shall continue to deal solely and
directly with such Lender in

                                      -38-
<PAGE>
connection with such Lender's rights and obligations under the Loan Documents
and (iv) such Lender shall not be permitted to provide Confidential Information
to its Participant unless (A) such Participant executes and delivers to the
Administrative Agent a Confidentiality Agreement or (B) the provision of
Confidential Information is otherwise permitted under the terms of such Lender's
Confidentiality Agreement. Any agreement or instrument pursuant to which a
Lender sells a participation shall provide that such Lender shall retain the
sole right to enforce the rights and remedies of a Lender under the Loan
Documents and to approve any amendment, modification or waiver of any provision
of the Loan Documents; provided that, such agreement or instrument may provide
that such Lender will not, without the consent of the Participant, take any
action of the type described in clauses (a) through (d) or clause (g) of Section
10.1 with respect to Obligations participated in by that Participant. Subject to
clause (e), Royalty Sub agrees that each Participant shall be entitled to the
benefits of Sections 4.3, 4.4, 4.5, 4.6, 7.1.1, 10.3 and 10.4 to the same extent
as if it were a Lender and had acquired its interest by assignment pursuant to
clause (c). To the extent permitted by law, each Participant also shall be
entitled to the benefits of Section 4.9 as though it were a Lender, but only if
such Participant agrees to be subject to Section 4.8 as though it were a Lender.

     (e) A Participant shall not be entitled to receive any greater payment
under Section 4.3, 4.4, 4.5, 4.6, 10.3 or 10.4 than the applicable Lender would
have been entitled to receive with respect to the participation sold to such
Participant, unless the sale of the participation to such Participant is made
with Royalty Sub's prior written consent. A Participant that would be a Non-U.S.
Lender if it were a Lender shall not be entitled to the benefits of Section 4.6
unless Royalty Sub is notified of the participation sold to such Participant and
such Participant agrees, for the benefit of Royalty Sub, to comply with the
requirements set forth in Section 4.6 as though it were a Lender. In addition,
if at the time of the sale of such participation, any greater Taxes subject to
payment under Section 4.6 would apply to the Participant than applied to the
applicable Lender, then such Participant shall not be entitled to any payment
under Section 4.6 with respect to the portion of such Taxes as exceeds the Taxes
applicable to the Lender at the time of the sale of the participation unless the
Participant's request for Royalty Sub's prior written consent for the
Participation described in the first sentence of this clause states that such
greater Taxes would be applicable to such Participant. Any Lender may at any
time pledge or assign a Lien in all or any portion of its rights under this
Agreement to secure obligations of such Lender, including any pledge or
assignment to secure obligations to a Federal Reserve Bank; provided that no
such pledge or assignment of a Lien shall release a Lender from any of its
obligations hereunder or substitute any such pledgee or assignee for such Lender
as a party hereto.

     SECTION 10.12. Other Transactions. Nothing contained herein shall preclude
the Administrative Agent or any Lender from engaging in any transaction, in
addition to those contemplated by the Loan Documents, with Royalty Sub or any of
its Affiliates in which Royalty Sub or such Affiliate is not restricted hereby
from engaging with any other Person.

     SECTION 10.13. Forum Selection and Consent to Jurisdiction. ANY LITIGATION
BASED HEREON, OR ARISING OUT OF, UNDER, OR IN CONNECTION WITH, ANY LOAN
DOCUMENT, OR ANY COURSE OF CONDUCT, COURSE OF DEALING, STATEMENTS (WHETHER ORAL
OR WRITTEN) OR ACTIONS OF THE ADMINISTRATIVE AGENT, THE LENDERS, THE PLEDGOR OR
ROYALTY SUB IN

                                      -39-
<PAGE>
CONNECTION HEREWITH OR THEREWITH MAY BE BROUGHT AND MAINTAINED IN THE COURTS OF
THE STATE OF NEW YORK OR IN THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN
DISTRICT OF NEW YORK; PROVIDED THAT ANY SUIT SEEKING ENFORCEMENT AGAINST ANY
COLLATERAL OR OTHER PROPERTY MAY BE BROUGHT, AT THE ADMINISTRATIVE AGENT'S
OPTION, IN THE COURTS OF ANY JURISDICTION WHERE SUCH COLLATERAL OR OTHER
PROPERTY MAY BE FOUND. THE PLEDGOR AND ROYALTY SUB IRREVOCABLY CONSENT TO THE
SERVICE OF PROCESS BY REGISTERED MAIL, POSTAGE PREPAID, OR BY PERSONAL SERVICE
WITHIN OR WITHOUT THE STATE OF NEW YORK AT THE ADDRESSES FOR NOTICES SPECIFIED
IN SECTION 10.2. EACH OF THE PARTIES HERETO HAS IRREVOCABLY DESIGNATED,
APPOINTED AND EMPOWERED THE RESPECTIVE PERSONS NAMED IN EXHIBIT I AS ITS
DESIGNEE, APPOINTEE AND AGENT TO RECEIVE, ACCEPT AND ACKNOWLEDGE FOR AND ON ITS
BEHALF, AND ITS PROPERTIES, ASSETS AND REVENUES, SERVICE OF ANY AND ALL LEGAL
PROCESS, SUMMONS, NOTICES AND DOCUMENTS THAT MAY BE SERVED IN ANY SUIT, ACTION
OR PROCEEDING BROUGHT AGAINST SUCH PARTY IN ANY UNITED STATES OR STATE COURT
ARISING OUT OF OR RELATING TO THIS AGREEMENT. THE PLEDGOR AND ROYALTY SUB HEREBY
EXPRESSLY AND IRREVOCABLY WAIVE, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY
OBJECTION WHICH THEY MAY HAVE OR HEREAFTER MAY HAVE TO THE LAYING OF VENUE OF
ANY SUCH LITIGATION BROUGHT IN ANY SUCH COURT REFERRED TO ABOVE AND ANY CLAIM
THAT ANY SUCH LITIGATION HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. TO THE
EXTENT THAT THE PLEDGOR AND ROYALTY SUB HAVE OR HEREAFTER MAY ACQUIRE ANY
IMMUNITY FROM JURISDICTION OF ANY COURT OR FROM ANY LEGAL PROCESS (WHETHER
THROUGH SERVICE OR NOTICE, ATTACHMENT PRIOR TO JUDGMENT, ATTACHMENT IN AID OF
EXECUTION OR OTHERWISE) WITH RESPECT TO THEMSELVES OR THEIR PROPERTY, THE
PLEDGOR AND ROYALTY SUB HEREBY IRREVOCABLY WAIVE TO THE FULLEST EXTENT PERMITTED
BY LAW SUCH IMMUNITY IN RESPECT OF THEIR OBLIGATIONS UNDER THE LOAN DOCUMENTS.

     SECTION 10.14. Waiver of Jury Trial. THE ADMINISTRATIVE AGENT, EACH LENDER,
THE PLEDGOR AND ROYALTY SUB HEREBY KNOWINGLY, VOLUNTARILY AND INTENTIONALLY
WAIVE TO THE FULLEST EXTENT PERMITTED BY LAW ANY RIGHTS THEY MAY HAVE TO A TRIAL
BY JURY IN RESPECT OF ANY LITIGATION BASED HEREON, OR ARISING OUT OF, UNDER, OR
IN CONNECTION WITH, EACH LOAN DOCUMENT, OR ANY COURSE OF CONDUCT, COURSE OF
DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN) OR ACTIONS OF THE ADMINISTRATIVE
AGENT, SUCH LENDER, THE PLEDGOR OR ROYALTY SUB IN CONNECTION THEREWITH. THE
PLEDGOR AND ROYALTY SUB ACKNOWLEDGE AND AGREE THAT THEY HAVE RECEIVED FULL AND
SUFFICIENT CONSIDERATION FOR THIS PROVISION (AND EACH OTHER PROVISION OF EACH
OTHER LOAN DOCUMENT TO WHICH THEY ARE A PARTY) AND THAT THIS PROVISION IS A
MATERIAL

                                      -40-
<PAGE>
INDUCEMENT FOR THE ADMINISTRATIVE AGENT AND EACH LENDER ENTERING INTO THE LOAN
DOCUMENTS.

     SECTION 10.15. Immunity; Judgment Currency. (a) To the extent any Obligor
may in any jurisdiction claim for itself or its assets immunity (to the extent
such immunity may now or hereafter exist, whether on the grounds of sovereign
immunity or otherwise) from suit, execution, attachment (whether in aid of
execution, before judgment or otherwise) or other legal process (whether through
service or notice or otherwise), and to the extent that in any such jurisdiction
there may be attributed to itself or its assets such immunity (whether or not
claimed), each Obligor irrevocably agrees with respect to any matter arising
under this Agreement and each other Loan Document for the benefit of the Secured
Parties not to claim, and irrevocably waives, such immunity to the full extent
permitted by the laws of such jurisdiction.

     (b) If, for the purpose of obtaining a judgment or order in any court, it
is necessary to convert a sum due hereunder to any Secured Party from Dollars
into another currency, each Obligor hereby agrees, and each Secured Party
agrees, to the fullest extent that they may effectively do so, that the rate of
exchange used shall be that at which, in accordance with normal banking
procedures, such Secured Party could purchase Dollars with such other currency
in the Borough of Manhattan, The City of New York on the Business Day
immediately preceding the day on which final judgment is given.

     (c) The obligation of any Obligor in respect of any sum payable by it to a
Secured Party shall, notwithstanding any judgment or order in a currency other
than Dollars (the "Judgment Currency"), be discharged only to the extent that,
on the Business Day immediately following receipt by such Secured Party of such
security of any sum adjudged to be so due in the Judgment Currency, such Secured
Party may in accordance with normal banking procedures purchase Dollars with the
Judgment Currency. If the amount of Dollars so purchased is less than the sum
originally due to such Secured Party in the Judgment Currency (determined in the
manner set forth in clause (b) above), each Obligor agrees, as a separate
obligation and notwithstanding any such judgment, to indemnify such Secured
Party against such loss, and, if the amount of Dollars so purchased exceeds the
sum originally due to such Secured Party, such Secured Party agrees to remit to
such Obligor such excess, provided that such Secured Party shall have no
obligation to remit any such excess as long as such Obligor shall have failed to
pay to such Secured Party any obligations due and payable to such Secured Party
under any Loan Document, in which case such excess may be applied to such
obligations of such Obligor in accordance with the terms thereof. The foregoing
indemnity shall constitute a separate and independent obligation of each Obligor
and shall continue in full force and effect notwithstanding any such judgment or
order as aforesaid.

     SECTION 10.16. Limited Recourse. Each of the parties hereto accepts that
the enforceability against Royalty Sub of the obligations of Royalty Sub
hereunder shall be limited to the assets of Royalty Sub, whether tangible or
intangible, real or personal (including the Collateral) and the proceeds
thereof. Once all such assets have been realized upon and such assets (and
proceeds thereof) have been applied in accordance with Section 3 of the
Intercreditor Agreement, any outstanding obligations of Royalty Sub shall be
extinguished. Each of the parties hereto further agrees that it shall take no
action against any employee, director, principal, agent, officer or
administrator of Royalty Sub or the Administrative Agent in relation to this

                                      -41-
<PAGE>
Agreement; provided that nothing herein shall limit Royalty Sub (or its
permitted successors or assigns, including any party hereto that becomes such a
successor or assign) from pursuing claims, if any, against any such Person. The
foregoing provisions of this Section 10.16 shall not in any way limit, impair or
otherwise affect any rights of Administrative Agent or any Lender to proceed
against any Person (a) for intentional and willful fraud or intentional and
willful misrepresentations on the part of or by such Person and (b) for the
receipt of any distributions or payment to which Royalty Sub or any successor in
interest is entitled, other than distributions expressly permitted pursuant to
this Agreement and the Intercreditor Agreement. The provisions of this Section
10.16 shall survive termination of this Agreement.

     SECTION 10.17. Patriot Act. Each of the Lenders, the Administrative Agent
and the Lead Arranger hereby notifies Royalty Sub that pursuant to the
requirements of the U.S.A. Patriot Act, it is required to obtain, verify and
record information that identifies Royalty Sub, the Pledgor and certain of their
Affiliates, which information includes the name and address of the Pledgor and
Royalty Sub and other information that will allow such Lender, the Agents or the
Lead Arrangers, as the case may be, to identify the Pledgor and Royalty Sub in
accordance with the U.S.A. Patriot Act.

     SECTION 10.18. Intercreditor Provisions. Notwithstanding anything to the
contrary in this Agreement or in any other Loan Document (i) the Liens granted
to the Administrative Agent in favor of any of the Secured Parties pursuant to
this Agreement and the other Loan Documents, the exercise of any right related
to any collateral, and all rights of payment (including rights of setoff and
similar rights), shall be subject, in each case, to the terms of the
Intercreditor Agreement; and (ii) in the event of any direct conflict between
the express terms and provisions of this Agreement and the Intercreditor
Agreement or the Intercreditor Agreement and any other Loan Document, in each
case, with respect to the Liens granted to the Administrative Agent in favor of
the Secured Parties pursuant to this Agreement and the other Loan Documents, the
exercise of any right related to any collateral, and all rights of payment
(including rights of setoff), the Intercreditor Agreement shall control.

                                      -42-
<PAGE>
     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
executed by their respective officers thereunto duly authorized as of the day
and year first above written.

                                        DULOXETINE ROYALTY SUB

                                        By: /s/ Santiago M. Estrada
                                            ------------------------------------
                                        Name: Santiago M. Estrada
                                        Title: Vice President and Secretary

                                        Address: c/o Walkers SPV Limited
                                        P.O. Box 908GT, Walker House
                                        Mary Street, George Town, Grand Cayman
                                        Cayman Islands

                                        Facsimile No.: 345-945-4757
                                        Attention: The Director

                                        DULOXETINE HOLDCO ROYALTY SUB

                                        By: /s/ John L. Bradley, Jr.
                                            ------------------------------------
                                        Name: John L. Bradley, Jr.
                                        Title: Vice President

                                        Address: c/o Walkers SPV Limited
                                        P.O. Box 908GT, Walker House
                                        Mary Street, George Town, Grand Cayman
                                        Cayman Islands

                                        Facsimile No.: 345-945-4757
                                        Attention: The Director
<PAGE>
                                        QUINTILES TRANSNATIONAL CORP.

                                        (as party hereto with respect to
                                        Sections 5.1, 5.3 and 6.2 only)

                                        By: /s/ John L. Bradley, Jr.
                                            ------------------------------------
                                        Name: John L. Bradley, Jr.
                                        Title: Senior Vice President, Corporate
                                        Development

                                        Address: 4709 Creekstone Drive, Suite
                                        200 Durham, North Carolina 27703

                                        Facsimile No.: 919-998-2759
                                        Attention: John S. Russell, General
                                        Counsel
<PAGE>
                                        MORGAN STANLEY SENIOR FUNDING, INC.
                                           as the Administrative Agent, Lead
                                           Arranger and Lender

                                        By: /s/ Eugene F. Martin
                                            ------------------------------------
                                        Name: Eugene F. Martin
                                        Title: Vice President
<PAGE>
                                                                      SCHEDULE I

                                  PERCENTAGES;
                                  LIBOR OFFICE;
                                 DOMESTIC OFFICE

<TABLE>
<CAPTION>
                                    NOTICE ADDRESS/                 PERCENTAGES
    NAME OF LENDER             DOMESTIC AND LIBOR OFFICE          LOAN COMMITMENT
---------------------   ---------------------------------------   ---------------
<S>                     <C>                                       <C>
Morgan Stanley Senior   One Pierrepont Plaza
   Funding, Inc.        7th Floor                                       100%
                        300 Cadman Plaza West
                        Brooklyn, NY 11201

                        Documentation
                        Erma Dell'Aquila/Edward Henley
                        Telecopier: 718-754-7249 / 7250
                        E-mail:
                        Erma.Dell'Aquila@morganstanley.com
                        Edward.Henley@morganstanley.com

                        Loan Administration
                        Larry Benison / Adam Hoffman
                        Telecopier: 718-754-7249 / 7250
                        E-mail: Larry.Benison@morganstanley.com
                        Adam.Hoffman@morganstanley.com
</TABLE>
<PAGE>
                                     ANNEX A
                                  DEFINED TERMS

     "Accounts" means the Collection Account, the Holding Account, any
Repayment/Redemption Account, any Escrow Account, any Capital Account and any
other account established pursuant to the Intercreditor Agreement.

     "Acquisition" is defined in the first recital.

     "Acquisition Documents" means each of the Purchase and Sale Agreement, the
Bill of Sale and the Servicing Agreement.

     "Administrative Agent" is defined in the preamble and includes each other
Person appointed as the successor Administrative Agent pursuant to Section 9.4.

     "Affected Lender" is defined in Section 4.6.

     "Affiliate" means, with respect to any Person, any other Person that,
directly or indirectly, controls, is controlled by or is under common control
with such Person or is a director, officer or manager of such Person. For
purposes of this definition, "control" of a Person means the possession,
directly or indirectly, of the power (a) to vote 10% or more of the Capital
Securities (on a fully diluted basis) of such Person having ordinary voting
power for the election of directors, managing members or general partners (as
applicable) or (b) to direct or cause the direction of the management and
policies of such Person, whether through the ownership of Voting Securities, by
contract or otherwise.

     "Agents" means, collectively, each of the Administrative Agent and the
Syndication Agent.

     "Agreement" means, on any date, this Credit Agreement as originally in
effect on the Effective Date and as thereafter from time to time amended,
supplemented, amended and restated or otherwise modified from time to time and
in effect on such date.

     "Alternate Base Rate" means, on any date and with respect to all Base Rate
Loans, a fluctuating rate of interest per annum (rounded upward, if necessary,
to the next highest 1/16 of 1%) equal to the higher of

          (a)  the Base Rate in effect on such day; and

          (b)  the Federal Funds Rate in effect on such day plus 1/2 of 1%.

Changes in the rate of interest on that portion of any Loans maintained as Base
Rate Loans will take effect simultaneously with each change in the Alternate
Base Rate. The Administrative Agent will give notice promptly to Royalty Sub and
the Lenders of changes in the Alternate Base Rate; provided that the failure to
give such notice shall not affect the Alternate Base Rate in effect after such
change.

                                      A-1
<PAGE>
     "Applicable Law" means, with respect to any Person, all laws, rules,
regulations and orders of Governmental Authorities applicable to such Person or
any of its properties or assets.

     "Applicable Margin" means at any time, 4.50% in the case of Loans
maintained as LIBO Rate Loans and 3.50% in the case of Loans maintained as Base
Rate Loans.

     "Approved Fund" means any Person (other than a natural Person) that (a) is
or will be engaged in making, purchasing, holding or otherwise investing in
commercial loans and similar extensions of credit in the ordinary course of its
business, and (b) is administered or managed by a Lender, an Affiliate of a
Lender or an entity or an Affiliate of an entity that administers or manages a
Lender.

     "Authorized Officer" means, relative to any Obligor, those of its officers,
general partners or managing members (as applicable) whose signatures and
incumbency shall have been certified to the Administrative Agent and the Lenders
pursuant to Section 5.1.

     "Base Rate" means the rate from time to time published in the "Money Rates"
section of The Wall Street Journal as being the "Prime Rate" (or, if more than
one rate is published as the "Prime Rate", then the highest of such rates). The
Base Rate will change as of the date of publication in The Wall Street Journal
of a "Prime Rate" that is different from that published on the preceding
Business Day. In the event that The Wall Street Journal shall, for any reason,
fail or cease to publish the "Prime Rate", the Administrative Agent shall choose
a reasonably comparable index or source to use as the basis for the Base Rate.

     "Base Rate Loan" means a Loan bearing interest at a fluctuating rate
determined by reference to the Alternate Base Rate.

     "Bill of Sale" means, collectively, the Pledgor Bill of Sale and the
Royalty Sub Bill of Sale.

     "Board Resolution" means a copy of a resolution certified by an officer of
Royalty Sub as having been duly adopted by the board of directors of Royalty Sub
and being in full force and effect on the date of such certification.

     "Borrowing" means the Loans made by all Lenders required to make such Loans
on the Closing Date and pursuant to the Borrowing Request in accordance with
Section 2.2.

     "Borrowing Request" means a Loan request and certificate duly executed by
an Authorized Officer of Royalty Sub, substantially in the form of Exhibit B
hereto.

     "Business Day" means (a) any day that is not a Saturday, Sunday or legal
holiday on which commercial banks are authorized or required to be closed in New
York, New York and (b) for purposes of calculating amounts at the London
interbank offered rate and related calculations relative to the making,
continuing, prepaying or repaying of Indebtedness in respect thereof, any day
that is a Business Day described in clause (a) that is also a day on which
dealings in U.S. dollars are carried on in the London interbank market.

                                      A-2
<PAGE>
     "Calculation Date" means, for any Payment Date, the fifth Business Day
immediately preceding such Payment Date.

     "Capital Account" is defined in Section 3.1(a) of the Intercreditor
Agreement.

     "Capital Securities" means, with respect to any Person, all shares,
interests, participations or other equivalents (however designated, whether
voting or non-voting) of such Person's capital, whether now outstanding or
issued after the Closing Date, including common shares, ordinary shares,
preferred shares, membership interests or share capital in a limited liability
company or other Person, limited or general partnership interests in a
partnership, beneficial interests in trusts or any other equivalent of such
ownership interest or any options, warrants and other rights to acquire such
shares or interests, including rights to allocations and distributions,
dividends, redemption payments and liquidation payments.

     "CERCLA" means the Comprehensive Environmental Response, Compensation and
Liability Act of 1980, as amended.

     "Change of Control" means that (i) the power to direct or cause the
direction of Quintiles' management and policies, whether possessed through
ownership or control of the stock of Quintiles or of a parent entity of
Quintiles, by contract or otherwise, is, after July 18, 2002, transferred to, or
acquired by, a person or entity (or related persons or entities) who did not
possess such power prior to July 18, 2002 or (ii) Quintiles is a party to a
merger or similar transaction and is not the surviving entity of such
transaction, unless the person or entity (or related persons or entities)
possessing, as of July 18, 2002, the power to direct or cause the direction of
the management and policies of Quintiles possess such power, immediately after
such transaction, with regard to the entity surviving such transaction.

     "Change of Control Event" means either:

          (a) (i) Quintiles experiences (or a successor of Quintiles
     experiences) a Change of Control at any time during the term of the
     Co-Promotion Agreement involving a person or entity who is listed in
     Exhibit 10.8 of the Co-Promotion Agreement and (ii)(x) Lilly terminates the
     Co-Promotion Agreement with respect to such Change of Control or (y) the
     surviving or new entity as a result of such Change of Control, if not
     Quintiles, does not agree in writing to assume and perform all of
     Quintiles' obligations under the Co-Promotion Agreement pursuant to the
     provisions thereof; or

          (b) Quintiles experiences (or a successor of Quintiles experiences) a
     Change of Control at any time during the term of the Co-Promotion Agreement
     involving companies debarred under the United States Generic Drug
     Enforcement Act of 1992 (21 U.S.C. Section 335a et seq.), as amended from
     time to time, or a company that cannot certify to Lilly that, to the best
     of its knowledge, it is in compliance with the provisions of the United
     States Generic Drug Enforcement Act of 1992 (21 U.S.C. Section 335a et
     seq.), as amended from time to time, and not using the services of any
     person or entity debarred under the United States Generic Drug Enforcement
     Act of 1992 (21 U.S.C. Section 335a et seq.), as amended from time to time,
     unless, in each case, (i) Quintiles provides to Royalty Sub, the
     Administrative Agent and the Trustee no later than the time of such

                                      A-3
<PAGE>
     Change of Control an irrevocable written acknowledgment from Lilly that
     Lilly will not exercise its right to terminate the Co-Promotion Agreement
     under Section 10.8 thereof with respect to such Change of Control and (ii)
     the surviving or new entity as a result of such Change of Control, if not
     Quintiles, agrees in writing to assume and perform all of Quintiles'
     obligations under the Co-Promotion Agreement pursuant to the provisions
     thereof.

     "Class B Notes" means the Class B Notes issued pursuant to Section 2.16 of
the Indenture.

     "Closing Date" means the date of the Borrowing hereunder.

     "Closing Date Certificate" means the closing date certificate executed and
delivered by an Authorized Officer of Royalty Sub, substantially in the form of
Exhibit D hereto.

     "Code" means the Internal Revenue Code of 1986 and the regulations
thereunder, in each case as amended, reformed or otherwise modified from time to
time.

     "Collateral" means, collectively, the "Collateral" as defined in each of
the Loan Security Agreement, the First Lien Pledge and Security Agreement, and
all other collateral with respect to which the Administrative Agent (or its
agent) is granted a Lien to secure the Obligations.

     "Collection Account" is defined in Section 3.1(a) of the Intercreditor
Agreement.

     "Commitment" means, relative to any Lender, such Lender's obligation (if
any) to make Loans pursuant to Section 2.1.

     "Commitment Amount" means $125,000,000.

     "Commitment Termination Date" means the earlier of (a) October 18, 2005
(immediately after the making of the Loans on such date) and (b) the date on
which any Commitment Termination Event occurs. Upon the occurrence of any event
described above, the Commitments shall terminate automatically and without any
further action.

     "Commitment Termination Event" means

          (a) the occurrence of any Event of Default with respect to Royalty Sub
     described in clause (g) of Section 8.1; or

          (b) the occurrence and continuance of any other Event of Default and
     the giving of notice by the Administrative Agent, acting at the direction
     of the Required Lenders, to Royalty Sub that the Commitments have been
     terminated.

     "Confidential Information" means any and all information provided by Lilly
or Quintiles that is Quintiles Confidential Information or Lilly Confidential
Information, respectively, each as defined in the Co-Promotion Agreement.

                                      A-4
<PAGE>
     "Confidentiality Agreement" means, with respect to any Lender or any of its
Affiliates, a confidentiality agreement for the benefit of Royalty Sub provided
to the Administrative Agent on or prior to the Closing Date or a confidentiality
agreement for the benefit of Royalty Sub provided to the Administrative Agent
substantially in the form of Exhibit H.

     "Continuation/Conversion Notice" means a notice of continuation or
conversion and certificate duly executed by an Authorized Officer of Royalty
Sub, substantially in the form of Exhibit C hereto.

     "Controlled Group" means all members of a controlled group of corporations
and all members of a controlled group of trades or businesses (whether or not
incorporated) under common control which, together with Royalty Sub, are treated
as a single employer under Section 414(b) or 414(c) of the Code or Section 4001
of ERISA.

     "Co-Promotion Agreement" is defined in the first recital.

     "Default" means any Event of Default or any condition, occurrence, event or
act that, with the giving of notice or the lapse of time or both, would
constitute an Event of Default; provided that a failure to pay interest on the
Loans when such amount becomes due on any Payment Date other than the Stated
Maturity Date or a Mandatory Repayment Date shall not constitute a Default;
provided further that a failure to pay any such interest not so paid on any such
Payment Date in full (with additional interest thereon pursuant to Section
3.2.2) by the next succeeding Payment Date shall be an immediate Event of
Default.

     "Discharge of First Lien Obligations" has the meaning set forth in the
Intercreditor Agreement.

     "Distribution Report" is defined in the Intercreditor Agreement.

     "Dollar" or the sign "$" means lawful money of the United States.

     "Domestic Office" means the office of a Lender designated as its "Domestic
Office" on Schedule I hereto or in a Lender Assignment Agreement, or such other
office within the United States as may be designated from time to time by notice
from such Lender to the Administrative Agent and Royalty Sub.

     "Effective Date" means the date this Agreement becomes effective pursuant
to Section 10.8.

     "Eligible Assignee" means (a) a Lender; (b) an Affiliate of a Lender; (c)
an Approved Fund; (d) a commercial bank or other financial institution or (e)
any other Person (other than a natural Person, Royalty Sub, any Affiliate of
Royalty Sub or any other Person taking direction from, or working in concert
with, Royalty Sub or any of Royalty Sub's Affiliates), provided that in each
case such Person has executed and delivered a Confidentiality Agreement to the
Administrative Agent.

     "Eligible Institution" means any bank organized under the laws of the U.S.
or any state thereof or the District of Columbia (or any domestic branch of a
foreign bank), which at all times

                                      A-5
<PAGE>
has either (a) a long-term unsecured debt rating of at least A2 by Moody's and A
by S&P and Fitch or (b) a certificate of deposit rating of at least P-1 by
Moody's, A-1 by S&P and F1 by Fitch.

     "Eligible Investments" means, in each case, book-entry securities,
negotiable instruments or securities represented by instruments in bearer or
registered form that evidence:

          (a) direct obligations of, and obligations fully Guaranteed as to
     timely payment of principal and interest by, the U.S. or any agency or
     instrumentality thereof the obligations of which are backed by the full
     faith and credit of the U.S. (having original maturities of no more than
     365 days or such lesser time as is required for the distribution of funds);

          (b) demand deposits, time deposits or certificates of deposit of the
     Operating Bank or of depositary institutions or trust companies organized
     under the laws of the U.S. or any state thereof or the District of Columbia
     (or any domestic branch of a foreign bank) (i) having original maturities
     of no more than 365 days or such lesser time as is required for the
     distribution of funds; provided, that, at the time of investment or
     contractual commitment to invest therein, the short-term debt rating of
     such depositary institution or trust company shall be at least P-1 by
     Moody's, A-1 by S&P and F1 by Fitch or (ii) having maturities of more than
     365 days and, at the time of the investment or contractual commitment to
     invest therein, a rating of at least A2 by Moody's and A by S&P and Fitch;

          (c) corporate or municipal debt obligations (i) having remaining
     maturities of no more than 365 days or such lesser time as is required for
     the distribution of funds and having, at the time of the investment or
     contractual commitment to invest therein, a rating of at least P-1 or A2 by
     Moody's, A-1 or A by S&P and F1 or A by Fitch or (ii) having maturities of
     more than 365 days and, at the time of the investment or contractual
     commitment to invest therein, a rating of at least A2 by Moody's and A by
     S&P and Fitch;

          (d) investments in money market funds (including funds in respect of
     which the Administrative Agent, the Trustee or any of their respective
     Affiliates is investment manager or otherwise) having a rating of at least
     A2 by Moody's, Am by S&P and A by Fitch; or

          (e) notes or bankers' acceptances (having original maturities of no
     more than 365 days or such lesser time as is required for the distribution
     of funds) issued by any depositary institution or trust company referred to
     in clause (b) above;

provided, however, that no investment shall be made in any obligations of any
depositary institution or trust company that is identified in a written notice
to the Administrative Agent or, after the Discharge of First Lien Obligations,
the Trustee from Royalty Sub or Servicer as having a contractual right to set
off and apply any deposits held, and other indebtedness owing, by Royalty Sub to
or for the credit or the account of such depositary institution or trust
company, unless such contractual right by its terms expressly excludes all
Eligible Investments.

                                      A-6
<PAGE>
     "Environmental Laws" means all applicable federal, state or local statutes,
laws, ordinances, codes, rules, regulations and guidelines (including consent
decrees and administrative orders) relating to public health and safety and
protection of the environment.

     "Equity Interests" means, with respect to any Person, all shares,
interests, participations or other equivalents (however designated, whether
voting or non-voting) of such Person's capital, whether now outstanding or
issued after the Closing Date, including common shares, ordinary shares,
preferred shares, membership interests or share capital in a limited liability
company or other Person, limited or general partnership interests in a
partnership, beneficial interests in trusts or any other equivalent of such
ownership interest or any options, warrants and other rights to acquire such
shares or interests, including rights to allocations and distributions,
dividends, redemption payments and liquidation payments.

     "ERISA" means the Employee Retirement Income Security Act of 1974, as
amended, and any successor statute thereto of similar import, together with the
regulations thereunder, in each case as in effect from time to time. References
to Sections of ERISA also refer to any successor Sections thereto.

     "Escrow Account" is defined in Section 3.1(a) of the Intercreditor
Agreement.

     "Event of Default" is defined in Section 8.1.

     "Exchange Act" means the U.S. Securities Exchange Act of 1934, as amended.

     "Exemption Certificate" is defined in clause (e) of Section 4.6.

     "Federal Funds Rate" means, for any period, a fluctuating interest rate per
annum equal for each day during such period to

          (a) the weighted average of the rates on overnight federal funds
     transactions with members of the Federal Reserve System arranged by federal
     funds brokers, as published for such day (or, if such day is not a Business
     Day, for the next preceding Business Day) by the Federal Reserve Bank of
     New York; or

          (b) if such rate is not so published for any day which is a Business
     Day, the average of the quotations for such day on such transactions
     received by the Administrative Agent from three federal funds brokers of
     recognized standing selected by it.

     "Filing Agent" is defined in Section 5.7.

     "Filing Statements" is defined in Section 5.7.

     "Final Maturity Date" means, with respect to (a) the Original Class A
Notes, October 15, 2013, (b) with respect to any Class B Notes or Refinancing
Notes, the date specified in the indenture supplemental to the Indenture
providing for their issuance; provided, that the Final Maturity Date with
respect to any Class B Notes or Refinancing Notes shall be no earlier than

                                      A-7
<PAGE>
October 15, 2013, and (c) the Loans, the same meaning as "Stated Maturity Date"
as defined in the Agreement.

     "First Lien Pledge and Security Agreement" means the Pledge and Security
Agreement executed and delivered by an Authorized Officer of Pledgor,
substantially in the form of Exhibit E-2 hereto, as amended, supplemented,
amended and restated or otherwise modified from time to time.

     "Fiscal Year" means any period of twelve consecutive calendar months ending
on December 31; references to a Fiscal Year with a number corresponding to any
calendar year (e.g., the "2005 Fiscal Year") refer to the Fiscal Year ending on
December 31 of such calendar year.

     "Fitch" means Fitch, Inc. and any successor thereto or, if such corporation
or its successor shall for any reason no longer perform the functions of a
securities rating agency, "Fitch" shall be deemed to refer to any other
nationally recognized statistical rating organization (within the meaning
ascribed thereto by the Exchange Act) designated by Royalty Sub.

     "F.R.S. Board" means the Board of Governors of the Federal Reserve System
or any successor thereto.

     "GAAP" means generally accepted accounting principles in effect in the U.S.
from time to time.

     "Governmental Authority" means the government of the United States, any
other nation or any political subdivision thereof, whether state or local, and
any agency, authority, instrumentality, regulatory body, court, central bank or
other Person exercising executive, legislative, judicial, taxing, regulatory or
administrative powers or functions of or pertaining to government.

     "Guarantee" means any obligation, contingent or otherwise, of any Person
directly or indirectly guaranteeing any Indebtedness or other obligation of any
other Person and, without limiting the generality of the foregoing, any
obligation, direct or indirect, contingent or otherwise, of such Person (a) to
purchase or pay (or advance or supply funds for the purchase or payment of) such
Indebtedness or other obligation of such other Person or (b) entered into for
purposes of assuring in any other manner the obligee of such Indebtedness or
other obligation of the payment thereof or to protect such obligee against loss
in respect thereof (in whole or in part); provided, that the term "Guarantee"
shall not include endorsements for collection or deposit in the ordinary course
of business. The term "Guarantee" when used as a verb has a corresponding
meaning.

     "Hazardous Material" means

          (a) any "hazardous substance", as defined by CERCLA;

          (b) any "hazardous waste", as defined by the Resource Conservation and
     Recovery Act, as amended; or

                                      A-8
<PAGE>
          (c) any pollutant or contaminant or hazardous, dangerous or toxic
     chemical, material or substance (including any petroleum product) within
     the meaning of any other applicable federal, state or local law,
     regulation, ordinance or requirement (including consent decrees and
     administrative orders) relating to or imposing liability or standards of
     conduct concerning any hazardous, toxic or dangerous waste, substance or
     material, all as amended.

     "Hedge Agreement" means the interest rate cap agreement between Royalty Sub
and the Hedge Provider, having an effective date of the Closing Date.

     "Hedge Payment" means a net payment to the Hedge Provider by Royalty Sub on
the Closing Date.

     "Hedge Provider" means Morgan Stanley Capital Services Inc., the
counterparty of Royalty Sub under the Hedge Agreement.

     "herein", "hereof", "hereto", "hereunder" and similar terms contained in
any Loan Document refer to such Loan Document as a whole and not to any
particular Section, paragraph or provision of such Loan Document.

     "Holding Account" is defined in Section 3.1(a) of the Intercreditor
Agreement.

     "Indebtedness" means, with respect to any Person at any date of
determination (without duplication), (a) all indebtedness of such Person for
borrowed money, (b) all obligations of such Person evidenced by bonds,
debentures, notes or other similar instruments, (c) all obligations of such
Person as an account party in respect of letters of credit or other similar
instruments (including reimbursement obligations with respect thereto), (d) all
the obligations of such Person to pay the deferred and unpaid purchase price of
property or services, which purchase price is due more than 90 days after the
date of purchasing such property or service or taking delivery and title thereto
or the completion of such services, and payment deferrals arranged primarily as
a method of raising funds to acquire such property or service, (e) all monetary
obligations of such Person and its Subsidiaries under any leasing or similar
arrangement which have been (or, in accordance with GAAP, should be) classified
as capitalized leases, (f) all Guarantees of such Person in respect of any of
the foregoing, (g) all monetary obligations of such Person with respect to any
interest rate hedge, cap, floor, swap, option or other interest rate hedge
agreement entered into after the Closing Date, (h) all Indebtedness (as defined
in clauses (a) through (g) of this definition) of other Persons secured by a
lien on any asset of such Person, whether or not such Indebtedness is assumed by
such Person, and (i) all Indebtedness (as defined in clauses (a) through (g) of
this definition) of other Persons Guaranteed by such Person.

     "Indemnified Liabilities" is defined in Section 10.4.

     "Indemnified Parties" is defined in Section 10.4.

     "Indenture" is defined in the second recital.

     "Independent Consultant" means L.E.K. Consulting LLC.

                                      A-9
<PAGE>
     "Independent Consultant's Report" means the report of the Independent
Consultant included in the Private Placement Memorandum as Appendix A.

     "Initial Capital Amount Account" means an account established by or on
behalf of Royalty Sub in the Cayman Islands in connection with the initial
subscription for 1,000 ordinary shares of Royalty Sub in the amount of
U.S.$1,000 and the payment of a transaction fee in the amount of U.S.$1,000.

     "Intercreditor Agreement" means the Intercreditor Agreement, executed and
delivered by each Person party thereto, substantially in the form of Exhibit F
hereto, as amended, supplemented, amended and restated or otherwise modified
from time to time.

     "Interest Period" means, relative to any LIBO Rate Loan, (i) initially, the
period beginning on (and including) the Closing Date and ending on (but
excluding) the first Payment Date following the Closing Date and (ii)
thereafter, the period beginning on (and including) the date on which such LIBO
Rate Loan is made or continued as, or converted into, a LIBO Rate Loan pursuant
to Sections 2.3 or 2.4 and ending on (but excluding) the day which numerically
corresponds to such date three months thereafter (or, if such month has no
numerically corresponding day, on the last Business Day of such month); provided
that

          (a) each Interest Period shall end on a Payment Date; and

          (b) no Interest Period for any Loan may end later than the Stated
     Maturity Date.

     "Investment" means, relative to any Person,

          (a) any loan, advance or extension of credit made by such Person to
     any other Person, including the purchase by such Person of any bonds,
     notes, debentures or other debt securities of any other Person;

          (b) Guarantees in favor of any other Person; and

          (c) any Capital Securities held by such Person in any other Person.

The amount of any Investment shall be the original principal or capital amount
thereof less all returns of principal or equity thereon and shall, if made by
the transfer or exchange of property other than cash, be deemed to have been
made in an original principal or capital amount equal to the fair market value
of such property at the time of such Investment.

     "Involuntary Bankruptcy" means, with respect to Royalty Sub or the Pledgor,
without the consent or acquiescence of Royalty Sub or the Pledgor, respectively,
the entering of an order for relief or approving a petition for relief or
reorganization or any other petition seeking any reorganization, arrangement,
composition, readjustment, liquidation, dissolution or other similar relief
under any present or future bankruptcy, insolvency or similar statute, law or
regulation, or the filing of any such petition against Royalty Sub or the
Pledgor, respectively, which petition shall not be dismissed within 60 days, or,
without the consent or acquiescence of Royalty Sub or the Pledgor, respectively,
the entering of an order appointing a trustee, custodian, receiver or

                                      A-10
<PAGE>
liquidator of Royalty Sub or the Pledgor, respectively, or of all or any
substantial part of the property of Royalty Sub or the Pledgor, respectively,
which order shall not be dismissed within 60 days.

     "Judgment Currency" is defined in Section 10.15.

     "Lender Assignment Agreement" means an assignment agreement substantially
in the form of Exhibit G hereto.

     "Lenders" is defined in the preamble.

     "Lender's Environmental Liability" means any and all losses, liabilities,
obligations, penalties, claims, litigation, demands, defenses, costs, judgments,
suits, proceedings, damages (including consequential damages), disbursements or
expenses of any kind or nature whatsoever (including reasonable attorneys' fees
at trial and appellate levels and experts' fees and disbursements and expenses
incurred in investigating, defending against or prosecuting any litigation,
claim or proceeding) which may at any time be imposed upon, incurred by or
asserted or awarded against the Administrative Agent, any Lender or any of such
Person's Affiliates, shareholders, directors, officers, employees, and agents in
connection with or arising from:

          (a) any Hazardous Material on, in, under or affecting all or any
     portion of any property of Royalty Sub, the groundwater thereunder, or any
     surrounding areas thereof to the extent caused by Releases from Royalty
     Sub's or any of its predecessors' properties;

          (b) any misrepresentation, inaccuracy or breach of any warranty,
     contained or referred to in clause (r) of Section 6.1 (without regard to
     any qualifications or exceptions with respect to knowledge or materiality
     contained or referred to therein);

          (c) any violation or claim of violation by Royalty Sub or any of its
     Subsidiaries of any Environmental Laws; or

          (d) the imposition of any lien for damages caused by or the recovery
     of any costs for the cleanup, release or threatened release of Hazardous
     Material by Royalty Sub or any of its Subsidiaries, or in connection with
     any property owned or formerly owned by Royalty Sub or any of its
     Subsidiaries.

     "LIBO Rate" means a rate of interest equal to the per annum rate of
interest at which United States dollar deposits in an amount comparable to the
amount of the relevant LIBO Rate Loan and for a period equal to the relevant
Interest Period are offered in the London interbank eurodollar market at 11:00
a.m. (London time) two (2) Business Days prior to the commencement of such
Interest Period (or three (3) Business Days prior to the commencement of such
Interest Period if banks in London, England were not open and dealing in
offshore United States dollars on such second preceding Business Day), as
displayed in the Bloomberg Financial Markets system (or, if such rate is not so
displayed, such other comparable nationally available source selected by the
Administrative Agent in its sole discretion) or, if the Bloomberg Financial
Markets system or another authoritative source is not available, as the LIBO
Rate is otherwise determined by the Administrative Agent in its sole and
absolute discretion.

                                      A-11
<PAGE>
     "LIBO Rate Loan" means a Loan bearing interest, at all times during an
Interest Period applicable to such Loan, at a rate of interest determined by
reference to the LIBO Rate (Reserve Adjusted).

     "LIBO Rate (Reserve Adjusted)" means, relative to any Loan to be made,
continued or maintained as, or converted into, a LIBO Rate Loan for any Interest
Period, a rate per annum (rounded upwards, if necessary, to the nearest 1/16 of
1%) determined pursuant to the following formula:

                  LIBO Rate      =            LIBO Rate
                                   -------------------------------
              (Reserve Adjusted)   1.00 - LIBOR Reserve Percentage

The LIBO Rate (Reserve Adjusted) for any Interest Period for LIBO Rate Loans
will be determined by the Administrative Agent on the basis of the LIBOR Reserve
Percentage in effect two Business Days before the first day of such Interest
Period.

     "LIBOR Office" means the office of a Lender designated as its "LIBOR
Office" on Schedule I hereto or in a Lender Assignment Agreement, or such other
office designated from time to time by notice from such Lender to Royalty Sub
and the Administrative Agent, whether or not outside the United States, which
shall be making or maintaining the LIBO Rate Loans of such Lender.

     "LIBOR Reserve Percentage" means, relative to any Interest Period for LIBO
Rate Loans, the reserve percentage (expressed as a decimal) equal to the maximum
aggregate reserve requirements (including all basic, emergency, supplemental,
marginal and other reserves and taking into account any transitional adjustments
or other scheduled changes in reserve requirements) specified under regulations
issued from time to time by the F.R.S. Board and then applicable to assets or
liabilities consisting of or including "Eurocurrency Liabilities", as currently
defined in Regulation D of the F.R.S. Board, having a term approximately equal
or comparable to such Interest Period.

     "Lien" means any security interest, mortgage, pledge, hypothecation,
assignment, deposit arrangement, encumbrance, lien (statutory or otherwise),
charge against or interest in property or other priority or preferential
arrangement of any kind or nature whatsoever, in each case to secure payment of
a debt or performance of an obligation, including any conditional sale, any sale
with recourse against Royalty Sub or any agreement to give any security
interest.

     "Lilly" is defined in the first recital.

     "Liquidated Damages Event" means that Quintiles has breached (i) Section
6.2(c), Section 6.2(d) or Section 6.2(e) of the Purchase and Sale Agreement or
(ii) any other covenant in the Purchase and Sale Agreement, but only to the
extent for purposes of this clause (ii) that the actions or inactions giving
rise to such breach result in (x) a termination of the Co-Promotion Agreement
pursuant to the terms of the Co-Promotion Agreement or (y) the failure of Lilly
to make any Royalty Sub Payments required by the Co-Promotion Agreement pursuant
to the terms of the Co-Promotion Agreement for a period of at least six months,
unless Quintiles is in good

                                      A-12
<PAGE>
faith taking appropriate action to contest Lilly's failure to make such payments
under the Co-Promotion Agreement.

     "Loan" is defined in Section 2.1.

     "Loan Documents" means, collectively, this Agreement, the Intercreditor
Agreement, the Notes, the Loan Security Agreement, the First Lien Pledge and
Security Agreement, any deposit or securities account contract agreement with
respect to the Accounts, the account control agreement dated as of October 18,
2005, among Royalty Sub, Servicer, the Administrative Agent, the Trustee and
U.S. Bank National Association, as custodian thereunder (as amended or otherwise
modified from time to time), each other agreement pursuant to which the
Administrative Agent (or its agent) is granted a Lien to secure the Obligations
and each other agreement, certificate, document or instrument delivered in
connection with any Loan Document, whether or not specifically mentioned herein
or therein (but not including any Transaction Document).

     "Loan Security Agreement" means the Security Agreement executed and
delivered by an Authorized Officer of Royalty Sub, substantially in the form of
Exhibit E-1 hereto, as amended, supplemented, amended and restated or otherwise
modified from time to time.

     "Mandatory Repayment Date" is defined in Section 3.1.1.

     "Material Adverse Effect" means a material adverse effect on (i) the
ability of Quintiles, the Pledgor or Servicer, as the case may be, to perform
its obligations under any of the Transaction Documents or the Co-Promotion
Agreement, in each case to which it is a party, (ii) the validity or
enforceability of the Co-Promotion Agreement or the rights or remedies of
Royalty Sub under the Co-Promotion Agreement or (iii) the Royalty Sub Rights or
the ability of Royalty Sub to perform any of its obligations under the Notes,
the Agreement, the Loan Security Agreement and the Indenture.

     "Moody's" means Moody's Investors Service, Inc. and any successor thereto
or, if such corporation or its successor shall for any reason no longer perform
the functions of a securities rating agency, "Moody's" shall be deemed to refer
to any other nationally recognized statistical rating organization (within the
meaning ascribed thereto by the Exchange Act) designated by Royalty Sub.

     "MS" is defined in the preamble.

     "Non-Excluded Taxes" means any Taxes other than net income and franchise
Taxes imposed with respect to any Secured Party by any Governmental Authority
under the laws of which such Secured Party is organized or in which it maintains
its applicable lending office.

     "Non-U.S. Lender" means any Lender that is not a "United States person", as
defined under Section 7701(a)(30) of the Code.

     "Note" means a promissory note of Royalty Sub payable to any Lender, in the
form of Exhibit A hereto (as such promissory note may be amended, endorsed or
otherwise modified from time to time), evidencing the aggregate Indebtedness of
Royalty Sub to such Lender

                                      A-13
<PAGE>
resulting from outstanding Loans, and also means all other promissory notes
accepted from time to time in substitution therefor or renewal thereof.

     "Obligations" means all obligations (monetary or otherwise, whether
absolute or contingent, matured or unmatured) of Royalty Sub and each other
Obligor arising under or in connection with a Loan Document, and the principal
of and premium, if any, and interest (including interest accruing during the
pendency of any proceeding of the type described in clause (g) of Section 8.1,
whether or not allowed in such proceeding) on the Loans.

     "Obligor" means, as the context may require, Royalty Sub and each other
Person (other than Quintiles or a Secured Party) obligated under any Loan
Document.

     "Operating Bank" means U.S. Bank National Association or any other Eligible
Institution consented to by the Collection Agent at which the Accounts are held;
provided, that if at any time the Operating Bank ceases to be an Eligible
Institution, a successor shall be appointed by Servicer on behalf of the
Collection Agent and all Accounts shall thereafter be transferred to and be
maintained at such successor in the name of the Collection Agent and such
successor shall thereafter be the "Operating Bank".

     "Organic Document" means, relative to any Obligor, as applicable, its
certificate of incorporation, by-laws, certificate of partnership, partnership
agreement, certificate of formation, limited liability agreement, operating
agreement and all shareholder agreements, voting trusts and similar arrangements
applicable to any of such Obligor's Capital Securities.

     "Original Class A Notes" means the Duloxetine PhaRMA(SM) Second Lien 13%
Notes due 2013 of Royalty Sub in the initial outstanding principal balance of
U.S.$125,000,000, substantially in the form of Exhibit A to the Indenture.

     "Other Taxes" means any and all stamp, documentary or similar Taxes, or any
other excise or property Taxes or similar levies that arise on account of any
payment made or required to be made under any Loan Document or from the
execution, delivery, registration, recording or enforcement of any Loan
Document.

     "Participant" is defined in Section 10.11.

     "Payment Date" means each January 15, April 15, July 15 and October 15,
commencing on January 15, 2006 and including the Final Maturity Date; provided,
that, if any such date would otherwise fall on a day that is not a Business Day,
the Payment Date falling on such date shall be the first following day that is a
Business Day; provided, further, that, if any such following Business Day would
occur in the succeeding month, then the Payment Date shall be the first Business
Day preceding such date.

     "PBGC" means the Pension Benefit Guaranty Corporation and any Person
succeeding to any or all of its functions under ERISA.

     "Pension Plan" means a "pension plan", as such term is defined in Section
3(2) of ERISA, which is subject to Title IV of ERISA (other than a multiemployer
plan as defined in Section 4001(a)(3) of ERISA), and to which Royalty Sub or any
corporation, trade or business

                                      A-14
<PAGE>
that is, along with Royalty Sub, a member of a Controlled Group, may have
liability, including any liability by reason of having been a substantial
employer within the meaning of Section 4063 of ERISA at any time during the
preceding five years, or by reason of being deemed to be a contributing sponsor
under Section 4069 of ERISA.

     "Percentage" means, relative to any Lender, the applicable percentage
relating to Loans set forth opposite its name on Schedule I hereto under the
Commitment column or set forth in a Lender Assignment Agreement under the
Commitment column, as such percentage may be adjusted from time to time pursuant
to Lender Assignment Agreements executed by such Lender and its assignee Lender
and delivered pursuant to Section 10.11.

     "Permitted Lien" means (a) any lien for Taxes, assessments and governmental
charges or levies not yet due and payable or which are being contested in good
faith by appropriate proceedings, (b) any Lien created in favor of the
Administrative Agent or the Trustee and (c) any other Lien expressly permitted
under the Transaction Documents.

     "Person" means any natural person, firm, corporation, limited liability
company, partnership, joint venture, association, joint-stock company, trust,
unincorporated organization, Governmental Authority or any other legal entity,
including public bodies, whether acting in an individual, fiduciary or other
capacity.

     "Pledgor" is defined in the preamble.

     "Pledgor Bill of Sale" means the Bill of Sale, dated as of the Closing
Date, executed by Quintiles and the Pledgor, substantially in the form of
Exhibit A to the Purchase and Sale Agreement.

     "Private Placement Memorandum" means the private placement memorandum of
Royalty Sub for the Original Class A Notes dated October 14, 2005.

     "Product" means a pharmaceutical product for humans, owned or controlled by
Lilly, containing duloxetine hydrochloride (also known as, according to Chemical
Abstracts' registry #136434-34-9,
(S)-(+)-N-methyl-y-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride) as
the active pharmaceutical ingredient, United States patent numbers 5,023,269 and
5,508,276.

     "Purchase and Sale Agreement" is defined in the first recital.

     "Quintiles" is defined in the first recital.

     "Register" is defined in clause (a) of Section 2.5.

     "Repayment/Redemption Account" is defined in Section 3.1(a) of the
Intercreditor Agreement.

     "Replacement Lender" is defined in Section 4.6.

     "Replacement Notice" is defined in Section 4.6.

                                      A-15
<PAGE>
     "Required Lenders" means, at any time, Lenders holding more than 50% of the
Total Exposure Amount.

     "Restricted Payment" means the declaration or payment of any dividend
(other than dividends payable solely in Capital Securities of Royalty Sub) on,
or the making of any payment or distribution on account of, or setting apart
assets for a sinking or other analogous fund for, the purchase, redemption,
defeasance, retirement or other acquisition of any class of Capital Securities
of Royalty Sub or any warrants or options to purchase any such Capital
Securities, whether now or hereafter outstanding, or the making of any other
distribution in respect thereof, either directly or indirectly, whether in cash
or property, obligations of Royalty Sub or otherwise.

     "Royalty Sub" is defined in the preamble.

     "Royalty Sub Bill of Sale" means the Bill of Sale, dated as of the Closing
Date, executed by the Pledgor and Royalty Sub, substantially in the form of
Exhibit B to the Purchase and Sale Agreement.

     "Royalty Sub Payments" means all royalties and other compensation, payments
and reimbursements paid, owed, accrued or otherwise required to be paid by Lilly
to Quintiles pursuant to the Co-Promotion Agreement, including (i) all payments
that may be required by (A) Sections 5.6, 5.7, 5.8, 5.13 and 5.14 of the
Co-Promotion Agreement with respect to royalty and other payments, (B) Article
10 of the Co-Promotion Agreement with respect to payments upon certain events of
termination of the Co-Promotion Agreement and (C) Section 11.3 of the
Co-Promotion Agreement with respect to Lilly's continuing responsibility for
paying Quintiles the payments required by Section 5.7 of the Co-Promotion
Agreement in the event of Lilly's license, sale or assignment of its
intellectual property relating to the Product as set forth in such Section 11.3
and (ii) additional payments or consideration paid to Quintiles in connection
with any amendment, restatement, supplement, modification or waiver of the
Co-Promotion Agreement.

     "Royalty Sub Rights" means the assets sold, transferred, conveyed,
assigned, contributed and granted by Quintiles to the Pledgor, and by the
Pledgor to Royalty Sub, pursuant to the Purchase and Sale Agreement and the
respective Bill of Sale, which shall consist of (i) the rights of Quintiles
under the Co-Promotion Agreement (A) to receive all Royalty Sub Payments and (B)
to receive quarterly net sales reports under Section 5.10 of the Co-Promotion
Agreement from Lilly showing net sales for such quarter and (ii) the proceeds of
and the rights to enforce each of the foregoing.

     "S&P" means Standard & Poor's Ratings Services, a division of The
McGraw-Hill Companies, Inc., and any successor thereto or, if such division or
its successor shall for any reason no longer perform the functions of a
securities rating agency, "S&P" shall be deemed to refer to any other nationally
recognized statistical rating organization (within the meaning ascribed thereto
by the Exchange Act) designated by Royalty Sub.

     "Second Lien Notes" is defined in the second recital.

     "Second Lien Note Documents" means each of the Indenture, the Second Lien
Notes, the Class B Notes, the Second Lien Pledge and Security Agreement and the
Note Purchase Agreements (as defined in the Indenture) with respect to the
Second Lien Notes.

                                      A-16
<PAGE>
     "Second Lien Pledge and Security Agreement" means that certain second lien
pledge and security agreement dated as of the Closing Date made by the Pledgor
to the Trustee pursuant to the terms of the Indenture, including the Annex and
Exhibits attached thereto, as amended, restated, supplemented or otherwise
modified from time to time.

     "Secured Parties" means, collectively, the Lenders, the Agents and, in each
case, each of their respective successors, transferees and assigns.

     "Security Agreement" means, as the context may require, the First Lien
Pledge and Security Agreement and the Loan Security Agreement.

     "Service Providers" means Servicer, the Administrative Agent, the Trustee,
the Collection Agent, the Calculation Agent, the Paying Agent, the Registrar,
the Operating Bank and any Person that becomes Servicer, the Administrative
Agent, the Trustee, the Collection Agent, the Calculation Agent, the Paying
Agent, the Registrar or the Operating Bank in accordance with the terms of the
applicable agreement and, subject to the written approval of the Administrative
Agent or, after the Discharge of First Lien Obligations, the Noteholders of a
majority of the Outstanding Principal Balance of the Senior Class of Notes, any
other Person designated as a Service Provider by Royalty Sub.

     "Servicer" means Quintiles, acting in its capacity as servicer pursuant to
the Servicing Agreement (or any other Person appointed by Royalty Sub to succeed
Quintiles as such or any successor thereto).

     "Servicing Agreement" means the servicing agreement dated as of the Closing
Date between Royalty Sub and Quintiles, including the Annex attached thereto, as
amended, restated, supplemented or otherwise modified from time to time in
accordance with the terms of the Agreement and the Indenture, if applicable.

     "Stated Maturity Date" means October 15, 2013.

     "Subsidiary" means, with respect to any Person, any other Person of which
more than 50% of the outstanding Voting Securities of such other Person
(irrespective of whether at the time Capital Securities of any other class or
classes of such other Person shall or might have voting power upon the
occurrence of any contingency) is at the time directly or indirectly owned or
controlled by such Person, by such Person and one or more other Subsidiaries of
such Person or by one or more other Subsidiaries of such Person.

     "Syndication Agent" is defined in the preamble.

     "Taxes" means any and all taxes, fees, levies, duties, tariffs, imposts and
other charges of any kind (together with any and all interest, penalties, loss,
damage, liability, expense, additions to tax and additional amounts or costs
incurred or imposed with respect thereto) now or hereafter imposed, levied,
collected, withheld or otherwise assessed by the U.S. or by any state, local,
foreign or other Governmental Authority (or any subdivision or agency thereof)
or other taxing authority, including taxes or other charges on or with respect
to income, franchises, windfall or other profits, gross receipts, property,
sales, use, capital stock, payroll, employment, social security, workers'
compensation, unemployment compensation or net worth and similar charges

                                      A-17
<PAGE>
and taxes or other charges in the nature of excise, deduction, withholding, ad
valorem, stamp, transfer, value added, taxes on goods and services, gains taxes,
license, registration and documentation fees, customs duties, tariffs and
similar charges.

     "Termination Date" means the date on which all Obligations have been paid
in full in cash.

     "Total Exposure Amount" means, on any date of determination (and without
duplication), the outstanding principal amount of all Loans (or, prior to the
Closing Date, all outstanding Commitments).

     "Transaction" is defined in the second recital.

     "Transaction Documents" means each of the Second Lien Note Documents and
each of the Acquisition Documents, in each case as amended, supplemented,
amended and restated or otherwise modified from time to time in accordance with
clause (a) of Section 7.2.

     "Trustee" means U.S. Bank National Association, a national banking
association, as initial trustee of the Notes under the Indenture, and any
successor appointed in accordance with the terms of the Indenture.

     "type" means, relative to any Loan, the portion thereof, if any, being
maintained as a Base Rate Loan or a LIBO Rate Loan.

     "UCC" means the Uniform Commercial Code as in effect from time to time in
the State of New York; provided, that, if, with respect to any financing
statement or by reason of any provisions of law, the perfection or the effect of
perfection or non-perfection of the Liens granted to the Administrative Agent or
the Trustee pursuant to the applicable Transaction Document is governed by the
Uniform Commercial Code as in effect in a jurisdiction of the United States
other than the State of New York, then "UCC" means the Uniform Commercial Code
as in effect from time to time in such other jurisdiction for purposes of the
provisions of each Transaction Document and any financing statement relating to
such perfection or effect of perfection or non-perfection.

     "U.S." or "United States" means the United States of America, its 50
states, each territory thereof and the District of Columbia.

     "Voluntary Bankruptcy" means, with respect to Royalty Sub or the Pledgor,
(i) the inability of Royalty Sub or the Pledgor, respectively, generally to pay
its debts as such debts become due, or an admission in writing by Royalty Sub or
the Pledgor, respectively, of its inability to pay its debts generally or a
general assignment by Royalty Sub or the Pledgor, respectively, for the benefit
of creditors, (ii) the filing of any petition or answer by Royalty Sub or the
Pledgor, respectively, seeking to adjudicate itself as bankrupt or insolvent, or
seeking for itself any liquidation, winding-up, reorganization, arrangement,
adjustment, protection, relief or composition of Royalty Sub or the Pledgor,
respectively, or its debts under any law relating to bankruptcy, insolvency,
receivership, winding-up, liquidation, reorganization, examination, relief of
debtors or other similar law now or hereafter in effect, or seeking, consenting
to or acquiescing in the entry of an order for relief in any case under any such
law, or the appointment

                                      A-18
<PAGE>
of or taking possession by a receiver, trustee, custodian, liquidator, examiner,
assignee, sequestrator or other similar official for Royalty Sub or the Pledgor,
respectively, or for any substantial part of its property, or (iii) corporate or
other entity action taken by Royalty Sub or the Pledgor, respectively, to
authorize any of the actions set forth above.

     "Voting Securities" means, with respect to any Person, Capital Securities
of any class or kind ordinarily having the power to vote for the election of
directors, managers or other voting members of the governing body of such
Person.

     "Welfare Plan" means a "welfare plan", as such term is defined in Section
3(1) of ERISA.

                                      A-19<PAGE>
                                                                [EXECUTION COPY]

                             INTERCREDITOR AGREEMENT

     This INTERCREDITOR AGREEMENT (this "Agreement"), is dated as of October 18,
2005 and entered into by and among (i) MORGAN STANLEY SENIOR FUNDING, INC., in
its capacity as administrative agent under the First Lien Documents (as defined
below), including its successors and assigns from time to time (the "First Lien
Agent"), (ii) U.S. BANK NATIONAL ASSOCIATION, in its capacity as trustee under
the Indenture (as defined below), including its successors and assigns from time
to time (the "Trustee"), (iii) U.S. BANK NATIONAL ASSOCIATION, as the initial
Collection Agent (as defined below), (iv) DULOXETINE ROYALTY SUB, an exempted
company incorporated with limited liability under the laws of the Cayman Islands
("Royalty Sub") and (v) DULOXETINE HOLDCO ROYALTY SUB, an exempted company
incorporated with limited liability under the laws of the Cayman Islands (the
"Pledgor"). Capitalized terms used herein but not otherwise defined herein have
the meanings set forth in Section 1 below.

                                    RECITALS

     WHEREAS, Royalty Sub, the Pledgor, the lenders party thereto and the First
Lien Agent have heretofore entered into a Credit Agreement, dated as of the date
hereof (as amended, restated, supplemented, modified or Refinanced from time to
time, the "First Lien Credit Agreement");

     WHEREAS, Royalty Sub and the Trustee have entered into an Indenture, dated
as of the date hereof (as amended, restated, supplemented, modified or
Refinanced from time to time, the "Indenture"), pursuant to which Royalty Sub
intends to issue on the Closing Date its Duloxetine PhaRMA(SM) Second Lien 13%
Notes due 2013 (the "Second Lien Notes") and following the Closing Date may
issue (following the Discharge of First Lien Obligations) its Class B Notes or
(pursuant to a Refinancing or following the Discharge of First Lien Obligations)
Refinancing Notes;

     WHEREAS, the obligations of Royalty Sub under the First Lien Documents will
be secured by substantially all the assets of Royalty Sub and a pledge of
substantiality all of the Capital Securities of Royalty Sub held by the Pledgor,
pursuant to the terms of the First Lien Collateral Documents;

     WHEREAS, the obligations of Royalty Sub under the Second Lien Documents
will be secured by substantially all the assets of Royalty Sub and a pledge of
substantially all of the Capital Securities of Royalty Sub held by the Pledgor,
pursuant to the terms of the Second Lien Collateral Documents;

     WHEREAS, the priority of payments of the First Lien Obligations and the
Second Lien Obligations are set forth in this Agreement;

     WHEREAS, the Liens securing the Second Lien Obligations will be
subordinated and second in priority to the Liens securing the First Lien
Obligations; and
<PAGE>
     WHEREAS, the First Lien Documents and the Second Lien Documents provide,
among other things, that the parties thereto shall set forth in this Agreement
their respective rights and remedies with respect to the priority of payments
thereunder and the Liens on the Collateral.

     NOW, THEREFORE, in consideration of the foregoing, the mutual covenants and
obligations herein set forth and for other good and valuable consideration, the
sufficiency and receipt of which are hereby acknowledged, the parties hereto,
intending to be legally bound, hereby agree as follows:

                             SECTION 1. DEFINITIONS.

     SECTION 1.1. Defined Terms. Capitalized terms used herein shall have the
meanings set forth in Annex A hereto, and such Annex A is hereby incorporated
herein by reference. Capitalized terms, if any, used in this Agreement that are
not defined in Annex A hereto or otherwise defined herein shall have the
meanings given to such terms in Annex A to the Indenture.

     SECTION 1.2. Terms Generally. The definitions of terms herein shall apply
equally to the singular and plural forms of the terms defined, and vice versa. A
term has the meaning assigned to it and an accounting term not otherwise defined
has the meaning assigned to it in accordance with GAAP. Words of the masculine,
feminine or neuter gender shall mean and include the correlative words of other
genders. The words "include", "includes" and "including" and similar terms shall
be construed as if followed by the phrase "without limitation." The word "will"
shall be construed to have the same meaning and effect as the word "shall".
Unless the context requires otherwise (i) references to an agreement or other
document include references to such agreement or document as amended, restated,
supplemented or otherwise modified in accordance with the terms of this
Agreement, and the provisions of this Agreement apply to successive events and
transactions, (ii) references to any statute or other legislative provision
shall include any statutory or legislative modification or re-enactment thereof,
or any substitution therefor, (iii) any reference herein to any Person shall be
construed to include such Person's successors and permitted assigns, (iv) the
words "herein", "hereof" and "hereunder", and words of similar import, shall be
construed to refer to this Agreement in its entirety and not to any particular
provision hereof, (v) all references herein to Exhibits or Sections shall be
construed to refer to Exhibits or Sections of this Agreement and (vi) the words
"asset" and "property" shall be construed to have the same meaning and effect
and to refer to any and all tangible and intangible assets and properties,
including cash, securities, accounts and contract rights.

                          SECTION 2. LIEN PRIORITIES.

     SECTION 2.1. Seniority. Notwithstanding the date, manner or order of grant,
attachment, perfection or validity of any Liens securing the Second Lien
Obligations granted on the Collateral or of any Liens securing the First Lien
Obligations granted on the Collateral and notwithstanding any provision of the
UCC, any Applicable Law or the Second Lien Documents or any other circumstance
whatsoever, the Trustee, on behalf of itself and the Second Lien Claimholders,
hereby agrees that: (i) any Lien on the Collateral securing any First Lien
Obligations now or hereafter held by or on behalf of the First Lien Agent or any
First Lien Claimholders or any agent or trustee therefor (including the
Collection Agent), regardless of how

                                       -2-
<PAGE>
acquired, whether by grant, possession, statute, operation of law, subrogation
or otherwise, shall be senior in all respects and prior to any Lien on the
Collateral securing any of the Second Lien Obligations; and (ii) any Lien on the
Collateral securing any of the Second Lien Obligations now or hereafter held by
or on behalf of the Trustee, any Second Lien Claimholders or any agent or
trustee therefor (including the Collection Agent) regardless of how acquired,
whether by grant, possession, statute, operation of law, subrogation or
otherwise, shall be junior and subordinate in all respects to all Liens on the
Collateral securing any First Lien Obligations.

     SECTION 2.2. Prohibition on Contesting Liens. Each of the Trustee, for
itself and on behalf of each Second Lien Claimholder, and the First Lien Agent,
for itself and on behalf of each First Lien Claimholder, agrees that it shall
not (and hereby waives any right to) contest or support any other Person in
contesting, in any proceeding (including any Insolvency or Liquidation
Proceeding), the priority, validity, perfection or enforceability of a Lien held
by or on behalf of any of the First Lien Claimholders in the Collateral or by or
on behalf of any of the Second Lien Claimholders in the Collateral, as the case
may be; provided, that nothing in this Agreement shall be construed to prevent
or impair the rights of any First Lien Claimholder to enforce this Agreement,
including the priority of the Liens securing the First Lien Obligations, as
provided in Section 4.1.

     SECTION 2.3. No New Liens. So long as the Discharge of First Lien
Obligations has not occurred, the parties hereto agree that no additional Liens
shall be granted or permitted on any asset of any Obligor to secure (i) any
Second Lien Obligation unless immediately after giving effect to such grant or
concurrently therewith, a Lien shall be granted on such asset to secure the
First Lien Obligations or (ii) any First Lien Obligation unless immediately
after giving effect to such grant or concurrently therewith, a Lien shall be
granted on such asset to secure the Second Lien Obligations; provided that, in
either event, the priority and seniority of such Liens shall be consistent with
the terms and provisions of Section 2.1.

     SECTION 2.4. Similar Liens and Agreements. It is the intention of the
parties hereto that the First Lien Collateral and the Second Lien Collateral be
identical. In furtherance of the foregoing and of Section 9.10, the parties
hereto agree, subject to the other provisions of this Agreement, upon request by
the First Lien Agent or the Trustee, to cooperate in good faith (and to direct
their counsel to cooperate in good faith) from time to time in order to (i)
determine the specific items included in the First Lien Collateral and the
Second Lien Collateral and the steps taken to perfect their respective Liens
thereon and the identity of the respective parties obligated under the First
Lien Documents and the Second Lien Documents and (ii) agree upon the forms of
the First Lien Collateral Documents and the Second Lien Collateral Documents.

                              SECTION 3. PAYMENTS

     SECTION 3.1. Establishment of Accounts.

          (a) Pursuant to the terms of the Servicing Agreement, Royalty Sub will
     cause Servicer, acting on behalf of Royalty Sub, to establish and maintain
     with the Operating Bank on its books and records in the name of Royalty
     Sub, subject to the Liens established under the First Lien Collateral
     Documents and the Second Lien Collateral Documents, (i) a collection
     account (the "Collection Account"), (ii) a holding account

                                       -3-
<PAGE>
     (the "Holding Account"), (iii) a repayment and redemption account (the
     "Repayment/Redemption Account"), (iv) an escrow account (the "Escrow
     Account"), (v) a capital contribution account (the "Capital Account"), and
     (vi) any additional accounts the establishment of which is set forth in a
     Board Resolution delivered by Royalty Sub to Servicer and the Collection
     Agent, in each case at such time as is set forth in this Section 3.1 or in
     such Board Resolution. Each Account shall be established and maintained as
     an Eligible Account so as to create, perfect and establish the priority of
     the Liens established under the First Lien Collateral Documents and the
     Second Lien Collateral Documents in such Account and all cash, Eligible
     Investments and other property from time to time deposited therein and
     otherwise to effectuate the Liens under the First Lien Collateral Documents
     and the Second Lien Collateral Documents.

          (b) The First Lien Agent and the Trustee agree that the Collection
     Agent, as agent for the First Lien Agent and the Trustee, shall have the
     power to direct withdrawals or transfers from the Accounts and to direct
     the investment and reinvestment of funds in the Accounts, subject to
     Section 3.2, and the Collection Agent shall make withdrawals and transfers
     from the Accounts in accordance with the terms of this Agreement based on
     the Relevant Information and as calculated by it pursuant to this
     Agreement. Each of Royalty Sub (for itself and on behalf of Servicer), the
     Collection Agent, the First Lien Agent and the Trustee acknowledges and
     agrees that the Accounts are "deposit accounts" or "investment property"
     within the meaning of Section 9-102 of the UCC, and Royalty Sub agrees to
     cause (or to direct Servicer to cause) each Operating Bank to enter into an
     agreement (a "Control Agreement") with Royalty Sub, the First Lien Agent
     and the Trustee pursuant to which such Operating Bank agrees to comply with
     any and all instructions of the First Lien Agent or the Trustee (or in
     either case the Collection Agent on its behalf) directing the disposition,
     investment and reinvestment of funds in all Accounts maintained with such
     Operating Bank without the further consent of Royalty Sub or Servicer or
     any other Person, and Royalty Sub shall take such other actions as are
     reasonably required by the First Lien Agent and the Trustee to establish
     its "control", for purposes of Section 9-314 of the UCC, over any such
     Accounts. Notwithstanding the terms of the immediately foregoing sentence
     or of any such Control Agreement, the Trustee agrees that it will not give
     any such instructions to any Operating Bank prior to the Discharge of First
     Lien Obligations without the prior written consent of the First Lien Agent.

          (c) If, at any time, any Account ceases to be an Eligible Account,
     Royalty Sub will cause Servicer or an agent thereof to, within ten Business
     Days, establish a new Account meeting the conditions set forth in this
     Section 3.1 in respect of such Account and transfer any cash or investments
     in the existing Account to such new Account, and, from the date such new
     Account is established, it shall have the same designation as the existing
     Account. If the Operating Bank should change at any time, then Royalty Sub
     will cause Servicer, acting on behalf of Royalty Sub, to thereupon promptly
     establish replacement Accounts as necessary at the successor Operating Bank
     and transfer the balance of funds in each Account then maintained at the
     former Operating Bank pursuant to the terms of the Servicing Agreement to
     such successor Operating Bank.

                                       -4-
<PAGE>
          (d) Royalty Sub will cause Servicer to establish and maintain the
     Collection Account at the Operating Bank not later than the Closing Date,
     and the Collection Account shall bear a designation clearly indicating that
     the funds deposited therein are held for the benefit of the Secured
     Creditors. Except as expressly provided herein, all Collections shall be
     deposited in the Collection Account and transferred therefrom in accordance
     with the terms of this Agreement. No funds shall be deposited in the
     Collection Account that do not constitute Collections except as expressly
     provided in this Agreement without the prior written consent of the
     Collection Agent.

          (e) Royalty Sub will cause Servicer to establish and maintain the
     Holding Account at the Operating Bank not later than the Closing Date, and
     the Holding Account shall bear a designation clearly indicating that the
     funds deposited therein are held for the benefit of the Second Lien
     Claimholders. Amounts shall be transferred into the Holding Account only
     following the Discharge of First Lien Obligations pursuant to clause
     (b)(vi) of Section 3.7. Any such amounts held in the Holding Account may be
     transferred (i) to the Collection Account pursuant to Section 3.6 or (ii)
     to Royalty Sub pursuant to Section 3.11.

          (f) Upon receipt of written notice of a voluntary or mandatory
     repayment of the Loans pursuant to the terms of the First Lien Credit
     Agreement, or a Redemption of any class of Notes, Royalty Sub will cause
     Servicer to establish and maintain a Repayment/Redemption Account at the
     Operating Bank which shall bear a designation clearly indicating that the
     funds or other assets deposited therein are held for the benefit of the
     Secured Creditors that are the subject of such voluntary or mandatory
     repayment or Redemption. All amounts received for the purpose of any such
     voluntary or mandatory repayment or Redemption shall be deposited in such
     Repayment/Redemption Account and shall be held in such Account until such
     amounts are applied to make such voluntary or mandatory repayment and
     payment of related First Lien Obligations, or pay the Redemption Price of
     such Notes, in each case in accordance with Section 3.9, together with any
     premium or related Second Lien Obligations and, if applicable, such Notes
     are cancelled by the Trustee.

          (g) Upon notice by the Trustee to the Collection Agent, the First Lien
     Agent and Servicer that any Noteholder, Agent Member or Beneficial Holder
     has not delivered a Confidentiality Agreement to the Registrar, Royalty Sub
     will cause Servicer to establish and maintain an Escrow Account at the
     Operating Bank in the name of the Trustee which shall bear a designation
     clearly indicating that the funds or other assets deposited therein are
     held for the benefit of any such Noteholder, Agent Member or Beneficial
     Holder. All amounts paid to the Trustee pursuant to Section 3.7 which are
     to be withheld from such Noteholder, Agent Member or Beneficial Holder
     pursuant to Section 2.5(d) of the Indenture shall be deposited in such
     Escrow Account and shall be held in such Account until such amounts are
     distributed as provided in Section 2.5(d) of the Indenture, and the
     Collection Agent agrees to act upon the direction of the Trustee to give
     effect to Section 2.5(d) of the Indenture.

          (h) Royalty Sub will cause Servicer to establish and maintain the
     Capital Account at the Operating Bank not later than the Closing Date which
     shall bear a designation

                                       -5-
<PAGE>
     clearly indicating that the funds or other assets deposited therein are
     held for the benefit of the Secured Creditors into which Quintiles (and the
     Pledgor, as applicable) shall deposit any capital contributions made to
     Royalty Sub. All such capital contributions shall be held in such Account
     and transferred (i) to the Collection Account only to the extent permitted
     by Section 3.8 and (ii) to the Repayment/Redemption Account only to the
     extent specifically provided for in any written notice of a voluntary or
     mandatory repayment of the Loans delivered to the First Lien Agent pursuant
     to the terms of the First Lien Credit Agreement or written notice of an
     Optional Redemption delivered to the Trustee pursuant to Section 3.1(a) of
     the Indenture, any written notice of a Mandatory Redemption delivered to
     the Trustee pursuant to Section 3.1(c) of the Indenture or any written
     notice of a Special Tax Redemption delivered to the Trustee pursuant to
     Section 3.1(d) of the Indenture, in each case for application pursuant to
     Section 3.7. Following the Discharge of First Lien Obligations, Royalty Sub
     also may direct the Collection Agent to deposit in the Capital Account all
     or a portion of any amount otherwise distributable to Royalty Sub pursuant
     to clause (b)(x) of Section 3.7 or Section 3.11, and the Collection Agent
     shall maintain a record of the portion of the funds on deposit in the
     Capital Account allocable to capital contributions and the portion
     allocable to such deposits.

     SECTION 3.2. Investments of Cash. Royalty Sub or Servicer, on its behalf,
shall direct the Operating Bank holding each Account in writing to invest and
reinvest the funds on deposit in the Accounts in Eligible Investments, to the
extent available to such Operating Bank; provided, however, that so long as an
Event of Default under the First Lien Credit Agreement or the Indenture has
occurred and is continuing, the First Lien Agent or, following the Discharge of
First Lien Obligations, the Trustee (or in either case the Collection Agent on
its behalf) shall direct the Operating Bank to invest such amount in Eligible
Investments described in clause (d) of the definition thereof from the time of
receipt thereof until such time as such amounts are required to be distributed
pursuant to the terms of this Agreement. In the absence of written direction
delivered to the Operating Bank from Royalty Sub or Servicer, the Operating Bank
shall invest any funds in Eligible Investments described in clause (d) of the
definition thereof. The Operating Bank shall make such investments and
reinvestments in accordance with the terms of the following provisions:

          (a) the Eligible Investments shall have maturities and other terms
     such that sufficient funds shall be available to make required payments
     pursuant to this Agreement on the Business Day immediately preceding the
     next occurring Payment Date after such investment is made;

          (b) if any funds to be invested are not received in the Accounts by
     1:00 p.m., New York City time, on any Business Day, such funds shall, if
     possible, be invested in overnight Eligible Investments; and

          (c) all interest and earnings on Eligible Investments held in the
     Accounts shall be invested in Eligible Investments on an overnight basis
     and credited to the appropriate Account until the next Payment Date.

                                       -6-
<PAGE>
Royalty Sub acknowledges that regulations of the U.S. Comptroller of the
Currency grant Royalty Sub the right to receive confirmations of security
transactions as they occur. Royalty Sub specifically waives receipt of such
confirmations to the extent permitted by Applicable Law and acknowledges that
the Operating Bank will furnish periodic cash transaction statements that will
detail all investment transactions.

     SECTION 3.3. Closing Date Deposits; Withdrawals and Transfers.

          (a) On the Closing Date, the First Lien Agent and the Trustee shall,
     subject to the receipt of written direction from Royalty Sub upon receipt
     of the proceeds from (i) the making of the Loans to Royalty Sub and (ii)
     the sale by Royalty Sub of the Second Lien Notes, make the following
     payments from such proceeds in the amounts so directed by Royalty Sub:

               (i) to such Persons as shall be specified by Royalty Sub, such
          Transaction Expenses as shall be due and payable in connection with
          the Transaction;

               (ii) the Hedge Payment to the Hedge Provider, as directed by
          Royalty Sub; and

               (iii) to Quintiles, in accordance with the Purchase and Sale
          Agreement, an amount equal to the Cash Purchase Price.

          (b) On the date of issuance of any Class B Notes or Refinancing Notes,
     the Collection Agent shall, subject to the receipt of written direction
     from Royalty Sub upon receipt of the proceeds of the sale by Royalty Sub of
     such Notes, make such payments and transfers as shall be specified in this
     Agreement and, to the extent not in contravention of the terms of this
     Agreement, in the Indenture, the related Board Resolution and any indenture
     supplemental to the Indenture in respect of such Notes, copies of which
     Board Resolution and supplemental indenture shall be attached to such
     written direction.

     SECTION 3.4. Capital Contributions. Royalty Sub will immediately forward
any capital contributions received by it from Quintiles or the Pledgor to the
Collection Agent for deposit in the Capital Account.

     SECTION 3.5. Calculation Date Calculations.

          (a) Prior to Each Payment Date. As soon as reasonably practicable
     after each Calculation Date (a "Relevant Calculation Date") but in no event
     later than 12:00 noon (New York City time) on the second Business Day prior
     to the immediately succeeding Payment Date, the Collection Agent shall,
     based on Servicer Information received by the Collection Agent, and based
     on information known to it or Relevant Information provided to it, make the
     following determinations and calculations (and each of the First Lien
     Agent, the Trustee and Royalty Sub (for itself and on behalf of Servicer)
     agrees to provide any Relevant Information reasonably requested by the
     Collection Agent for the purpose of making such determinations and
     calculations):

                                       -7-
<PAGE>
               (i) the amount of Collections received during the period
          commencing on the day immediately following the Calculation Date which
          immediately preceded such Relevant Calculation Date and ending on such
          Relevant Calculation Date;

               (ii) the balance of funds on deposit in each Account other than
          the Collection Account on such Relevant Calculation Date and the
          amount of interest earnings (net of losses and investment expenses),
          if any, on investments on funds on deposit therein from the day
          immediately following the Calculation Date which immediately preceded
          such Relevant Calculation Date and ending on such Relevant Calculation
          Date;

               (iii) the balance of funds on deposit in the Collection Account
          on such Relevant Calculation Date and the amount of interest earnings
          (net of losses and investment expenses), if any, on investments on
          funds on deposit therein from the day immediately following the
          Calculation Date which immediately preceded such Relevant Calculation
          Date and ending on such Relevant Calculation Date (including any
          amount to be transferred to the Collection Account pursuant to clause
          (a) of Section 3.6 in respect of such Payment Date);

               (iv) the Available Collections Amount for such Payment Date;

               (v) all amounts to be distributed to the Pledgor for the purpose
          of paying franchise Taxes and other fees and expenses required to
          maintain the Pledgor's corporate existence, and to pay other Taxes and
          general corporate and overhead expenses incurred by the Pledgor in the
          ordinary course of its business as a holding company for Royalty Sub;

               (vi) all fees, costs and expenses (including reasonable
          attorneys' fees and legal expenses) of the First Lien Claimholders
          under the First Lien Documents (including amounts payable pursuant to
          Section 10.3 of the First Lien Credit Agreement and all amounts
          payable in respect of Taxes pursuant to Section 4.6 of the First Lien
          Credit Agreement) and the Second Lien Claimholders under the Second
          Lien Documents not previously reimbursed;

               (vii) all other Expenses not previously reimbursed, with the
          amounts shown on all invoices attached to Servicer Information
          received by the Collection Agent for the reimbursement or payment of
          Expenses not previously paid or reimbursed;

               (viii) with respect to the Loans, (A) the applicable interest
          rate on any LIBO Rate Loans and (B) the amount of interest on all
          Loans, calculated pursuant to the terms of the First Lien Credit
          Agreement (including Section 3.2 of the First Lien Credit Agreement)
          for such Payment Date;

               (ix) with respect to the Notes, (A) the applicable interest rate
          on each class of Floating Rate Notes based on LIBOR determined on the
          Reference Date for the Interest Accrual Period beginning on such
          Payment Date and (B) the Interest

                                       -8-
<PAGE>
          Amount (including any Additional Interest and Additional Amounts) on
          each class of Floating Rate Notes and Fixed Rate Notes for such
          Payment Date;

               (x) the outstanding principal amount of the Loans on such Payment
          Date immediately prior to any principal payment on such Payment Date;

               (xi) if such Payment Date is a Mandatory Repayment Date or a date
          on which a voluntary prepayment of the Loans is to be made under the
          First Lien Credit Agreement, the amount necessary to make such
          voluntary prepayment or a mandatory repayment of the Loans, interest
          and other amounts due thereon and, if all Loans are being repaid on
          such Payment Date, all other First Lien Obligations on such Payment
          Date;

               (xii) if such Payment Date is a Redemption Date on which a
          Redemption of Notes is scheduled to occur, the amount necessary to pay
          the Redemption Price of the Notes to be repaid on such Redemption Date
          and the Redemption Premium, if any, to be paid in addition to such
          Redemption Price;

               (xiii) the amount of the Lilly Payment, if any, to be made on
          such Payment Date, provided such payment is being made in accordance
          with Section 3.10;

               (xiv) the shortfall, if any, of the Available Collections Amount
          for such Payment Date in respect of any amounts payable pursuant to
          clause (a)(v), (a)(vi) or (b)(iv) of Section 3.7, as applicable (a
          "Shortfall"), taking into account any Lilly Payment determined
          pursuant to clause (xiii) above and the payment of expenses described
          in clauses (v), (vi) and (vii) above payable on such Payment Date and,
          with respect to each Shortfall, the amount to be withdrawn from the
          Capital Account, if any, determined as provided in Section 3.8;

               (xv) a determination of whether the Interest Coverage Ratio is
          less than or equal to or greater than the specified ratio for such
          Payment Date set forth in Section 3.11; provided that for purposes of
          making such determination, if such determination is not reflected in
          Servicer Information received by the Collection Agent or if the
          Collection Agent has not received such Servicer Information on or
          before the third Business Day prior to the immediately succeeding
          Payment Date, the Interest Coverage Ratio for such Payment Date shall
          be deemed to be not equal to or greater than the specified ratio for
          such Payment Date set forth in Section 3.11; and

               (xvi) any other information, determinations and calculations
          reasonably required in order to give effect to the terms of this
          Agreement and the other Transaction Documents.

          (b) Following the Discharge of First Lien Obligations. In addition to
     the calculations and determinations to be made pursuant to clause (a)
     above, following the Discharge of First Lien Obligations (and prior
     thereto, if the Collection Agent determines that the Discharge of First
     Lien Obligations will occur on the immediately succeeding

                                       -9-
<PAGE>
     Payment Date), as soon as reasonably practicable after each Relevant
     Calculation Date but in no event later than 12:00 noon (New York City time)
     on the second Business Day prior to the immediately succeeding Payment
     Date, the Collection Agent shall, based on Servicer Information received by
     the Collection Agent, and based on information known to it or Relevant
     Information provided to it, make the following determinations and
     calculations (and each of the Trustee and Royalty Sub (for itself and on
     behalf of Servicer) agrees to provide any Relevant Information reasonably
     requested by the Collection Agent for the purpose of making such
     determinations and calculations):

               (i) the amount, if any, to be transferred from the Holding
          Account as of such Relevant Calculation Date to the Collection Account
          on such Payment Date in accordance with Section 3.6;

               (ii) (A) the Outstanding Principal Balance of each class of Notes
          on such Payment Date immediately prior to any principal payment on
          such Payment Date; (B) for each Payment Date, the principal amount
          required to be paid on the Second Lien Notes on such Payment Date that
          would reduce the Outstanding Principal Balance of the Second Lien
          Notes to the Remaining Scheduled Notes Balance for such Payment Date
          on the Class A Principal Payment Schedule; and (C) the amount of any
          other principal payment to be made in respect of each class of Notes
          on such Payment Date;

               (iii) any amount that will be deposited into the Holding Account
          pursuant to Section 3.7(b)(vi); and

               (iv) the amounts, if any, distributable to Royalty Sub on such
          Payment Date pursuant to clause (b)(x) of Section 3.7 or Section 3.11.

          (c) Calculation Report. Following the calculations and determinations
     by the Collection Agent described in clauses (a) and (b) above, as
     applicable, and not later than 1:00 p.m., New York City time, on the second
     Business Day prior to the immediately succeeding Payment Date, the
     Collection Agent shall provide to each of Servicer, Royalty Sub, the First
     Lien Agent and the Trustee a calculation report (a "Calculation Report")
     listing such determinations and calculations and the amount of the
     Available Collections Amount to be applied on such Payment Date to make
     each of the payments, transfers and deposits contemplated by Section 3.7 or
     Section 3.9, and any Lilly Payment due and payable on such date, as
     applicable, setting forth separately the payments to be made in respect of
     the First Lien Obligations and the Second Lien Obligations. In addition,
     following the Discharge of First Lien Obligations, such Calculation Report
     shall include the amount, if any, to be distributed to Royalty Sub from the
     Holding Account on such Payment Date as contemplated by Section 3.11. The
     calculations set forth in each Calculation Report shall be conclusive and
     binding on each Obligor, Servicer, each First Lien Claimholder and each
     Second Lien Claimholder, absent manifest error.

          (d) Capital Account Deposits. Following the Discharge of First Lien
     Obligations, not later than one Business Day prior to the immediately
     succeeding Payment Date, Royalty Sub shall advise the Trustee in writing as
     to the portion of amounts, if any,

                                      -10-
<PAGE>
     distributable to Royalty Sub on such Payment Date pursuant to clause (b)(x)
     of Section 3.7 or Section 3.11 to be deposited in the Capital Account on
     such Payment Date.

     SECTION 3.6. Payment Date First Step Transfers.

          (a) Each Payment Date. On each Payment Date, the Collection Agent
     shall transfer from any Account (other than the Collection Account) to the
     Collection Account the amount of earnings (net of losses and investment
     expenses), if any, earned as a result of investments of funds on deposit
     therein during the period from the second immediately preceding Calculation
     Date prior to such Payment Date and ending on the Calculation Date
     immediately preceding such Payment Date.

          (b) Following the Discharge of First Lien Obligations. In addition to
     the transfers to be made on each Payment Date pursuant to clause (a) above,
     on each Payment Date following the Discharge of First Lien Obligations, the
     Collection Agent shall transfer to the Collection Account the amount in the
     Holding Account as of the immediately preceding Calculation Date if (i) as
     of such Payment Date an Event of Default under the Indenture has occurred
     and is continuing, (ii) the Interest Coverage Ratio for such Payment Date
     is not equal to or greater than the specified ratio for such Payment Date
     set forth in Section 3.11 (as determined pursuant to clause (a)(xv) of
     Section 3.5), (iii) on or after June 15, 2008, as of such Payment Date the
     Patent Extension Event has not occurred or (iv) as of such Payment Date (x)
     the Trustee has received written notice from Noteholders of at least 25% of
     the Outstanding Principal Balance of the Class A Notes that a Material
     Adverse Development has occurred and (y) the Trustee has not received
     further written notice from Noteholders of a majority of the Outstanding
     Principal Balance of the Class A Notes that such Material Adverse
     Development has ended or is no longer applicable; provided, that if the
     Person acting as Trustee is not the same Person as the Collection Agent,
     the Trustee shall notify the Collection Agent of the occurrence of such
     event.

     SECTION 3.7. Payment Date Second Step Withdrawals.

          (a) Prior to the Discharge of First Lien Obligations. Prior to the
     Discharge of First Lien Obligations, on each Payment Date, after the
     applicable transfers provided for in clause (a) of Section 3.6 have been
     made, after making the distributions from the Repayment/Redemption Account,
     if any, pursuant to Section 3.9, and after the making of any Lilly Payment
     pursuant to Section 3.10, the Collection Agent shall distribute from the
     Collection Account to the First Lien Agent or the Trustee, as applicable,
     the amounts set forth below in the order of priority set forth below but,
     in each case, only to the extent that all amounts then required to be paid
     ranking prior thereto have been paid in full:

               (i) first, to the Pledgor, all amounts to be distributed to the
          Pledgor for the purpose of paying fees and expenses of the Pledgor of
          the type described in clause (a)(v) of Section 3.5 in an amount not to
          exceed $20,000 during any fiscal year;

               (ii) second, all fees, costs and expenses (including reasonable
          attorneys' fees and legal expenses) of the First Lien Claimholders
          under the First Lien

                                      -11-
<PAGE>
          Documents (including amounts payable pursuant to Section 10.3 of the
          First Lien Credit Agreement and all amounts payable in respect of
          Taxes pursuant to Section 4.6 of the First Lien Credit Agreement) not
          previously reimbursed;

               (iii) third, all fees, costs and expenses (including reasonable
          attorneys' fees and legal expenses) of the Second Lien Claimholders
          (other than the holders of Class B Notes, in such capacity) under the
          Second Lien Documents not previously reimbursed;

               (iv) fourth, all Expenses not previously reimbursed, with the
          amounts shown on all invoices attached to Servicer Information
          received by the Collection Agent for the reimbursement or payment of
          Expenses not previously paid or reimbursed;

               (v) fifth, to the First Lien Agent for distribution to the
          applicable First Lien Claimholders to the ratable payment of all
          interest payable under the First Lien Documents for such Payment Date
          (including interest accruing after the commencement of a proceeding in
          bankruptcy, insolvency or similar law, whether or not permitted as a
          claim under such law), taking into account any amounts paid pursuant
          to Section 3.8 on such Payment Date;

               (vi) sixth, to the Trustee for distribution to the applicable
          Second Lien Claimholders to the ratable payment of the Interest Amount
          then due and payable on the Class A Notes, taking into account any
          amounts paid pursuant to Section 3.8 on such Payment Date;

               (vii) seventh, to the ratable payment of the principal amount of
          the Loans then outstanding; and

               (viii) eighth, to the ratable payment of all other First Lien
          Obligations until the occurrence of the Discharge of First Lien
          Obligations.

          (b) Following the Discharge of First Lien Obligations. Following the
     Discharge of First Lien Obligations, on each Payment Date, after the
     applicable transfers provided for in Section 3.6 have been made, after
     making the distributions from the Repayment/Redemption Account, if any,
     pursuant to Section 3.9, and after the making of any Lilly Payment pursuant
     to Section 3.10, the Collection Agent shall distribute from the Collection
     Account to the Trustee the amounts set forth below in the order of priority
     set forth below but, in each case, only to the extent that all amounts then
     required to be paid ranking prior thereto have been paid in full:

               (i) first, to the Pledgor, all amounts to be distributed to the
          Pledgor for the purpose of paying fees and expenses of the Pledgor of
          the type described in clause (a)(v) of Section 3.5 in an amount not to
          exceed $20,000 during any fiscal year;

               (ii) second, all fees, costs and expenses (including reasonable
          attorneys' fees and legal expenses) of the Second Lien Claimholders
          under the Second Lien Documents not previously reimbursed;

                                      -12-
<PAGE>
               (iii) third, all Expenses not previously reimbursed, with the
          amounts shown on all invoices attached to Servicer Information
          received by the Collection Agent for the reimbursement or payment of
          Expenses not previously paid or reimbursed;

               (iv) fourth, to the Trustee for distribution to the applicable
          Second Lien Claimholders to the ratable payment of the Interest Amount
          then due and payable on the Class A Notes, taking into account any
          amounts paid pursuant to Section 3.8 on such Payment Date;

               (v) fifth, to the Trustee for distribution to the Noteholders,
          principal payments on the Class A Notes, allocated pro rata in
          proportion to the Outstanding Principal Balance of the Class A Notes
          held by such Noteholders, until the Outstanding Principal Balance of
          the Class A Notes equals the Scheduled Remaining Notes Balance for
          such Payment Date on the Class A Principal Payment Schedule; provided,
          however, that principal payments on the Class A Notes shall be made to
          the Trustee for distribution to the Noteholders, allocated pro rata in
          proportion to the Outstanding Principal Balance of the Class A Notes
          held by such Noteholders, regardless of the Scheduled Remaining Notes
          Balance Amount and until the Class A Notes have been paid in full, if
          (A) an Event of Default under the Indenture has occurred and is
          continuing, (B) on or after June 15, 2008, the Patent Extension Event
          has not occurred, (C)(x) the Trustee has received written notice from
          Noteholders of at least 25% of the Outstanding Principal Balance of
          the Class A Notes that a Material Adverse Development has occurred and
          (y) the Trustee has not received further written notice from
          Noteholders of a majority of the Outstanding Principal Balance of the
          Class A Notes that such Material Adverse Development has ended or is
          no longer applicable or (D) prior to the Discharge of First Lien
          Obligations, the First Lien Agent or any other First Lien Claimholder
          disposed of any portion of the Collateral following the occurrence of
          an Event of Default under the Credit Agreement without an Event of
          Default having occurred under the Indenture; provided, that if the
          Person acting as Trustee is not the same Person as the Collection
          Agent, the Trustee shall notify the Collection Agent of the occurrence
          of such event;

               (vi) sixth, if the Interest Coverage Ratio for such Payment Date
          is not equal to or greater than the specified ratio for such Payment
          Date set forth in Section 3.11 (as determined pursuant to clause
          (a)(xv) of Section 3.5) and the Outstanding Principal Balance of the
          Class A Notes is greater than zero, for deposit into the Holding
          Account;

               (vii) seventh, after the Class A Notes have been paid in full, to
          the Trustee for distribution to the Noteholders of the Class B Notes,
          if any, the Interest Amount on the Class B Notes;

               (viii) eighth, after the Class A Notes have been paid in full, to
          the Trustee for distribution to the Noteholders of the Class B Notes,
          if any, payment of the

                                      -13-
<PAGE>
          principal amount of the Class B Notes in accordance with their terms
          until the Class B Notes have been paid in full;

               (ix) ninth, to the ratable payment of all other Second Lien
          Obligations until all such amounts are paid in full; and

               (x) tenth, to Royalty Sub, all remaining amounts assuming that
          the Interest Coverage Ratio for such Payment Date is equal to or
          greater than the specified ratio for such Payment Date set forth in
          Section 3.11 (as determined pursuant to clause (a)(xv) of Section
          3.5).

          (c) To the extent that any monies are deposited in the Collection
     Account to reimburse prior distributions in respect of a Lilly Shortfall,
     such monies shall be paid to the First Lien Agent on behalf of the First
     Lien Claimholders or the Trustee on behalf of the Second Lien Claimholders,
     as applicable, prior to giving effect to this Section 3.7 to the extent
     that such monies otherwise would have been paid to such First Lien
     Claimholders or Second Lien Claimholders on the prior respective Payment
     Date in accordance with this Section 3.7 in the absence of such Lilly
     Shortfall.

     SECTION 3.8. Capital Account; Shortfalls. The Available Collections Amount
does not include the aggregate amount of funds on deposit in the Capital
Account; provided that if the Collection Agent has determined that a Shortfall
exists pursuant to the Calculation Report with respect to any Payment Date, and
there is a positive balance in the Capital Account on such Payment Date, then on
such Payment Date the Collection Agent shall withdraw from the Capital Account
an amount equal to the lesser of the Shortfall and the balance in the Capital
Account and distribute it to the First Lien Agent or the Trustee, as applicable,
in payment of the amounts payable as set forth in clause (a)(v), (a)(vi) or
(b)(iv) of Section 3.7, as applicable; provided further that the Collection
Agent shall make such a withdrawal from the Capital Account in respect of not
more than six Payment Dates in total and in respect of not more than any three
consecutive Payment Dates; provided further that no more than three such
withdrawals shall be made from the Capital Account in respect of interest on the
Notes prior to the Discharge of First Lien Obligations.

     SECTION 3.9. Repayment/Redemption.

          (a) Voluntary or Mandatory Repayment of Loans. On any Payment Date on
     which the Loans are to be subject to a voluntary or mandatory repayment
     (including pursuant to a voluntary repayment of the Loans with the proceeds
     of Class B Notes pursuant to clause (d) of Section 7.2 of the First Lien
     Credit Agreement), the Collection Agent shall distribute the amounts in the
     applicable Repayment/Redemption Account to the First Lien Agent for payment
     of all amounts then outstanding as calculated by the Collection Agent under
     clause (a)(xi) of Section 3.5, in accordance with the terms of the First
     Lien Documents.

          (b) Redemption of Notes. Subject to Section 3.15, on any Payment Date
     on which any class of Notes is to be the subject of a Redemption, in whole
     or in part, the Collection Agent shall distribute the amounts in the
     applicable Repayment/Redemption

                                      -14-
<PAGE>
     Account to the Trustee for payment of all amounts then outstanding as
     calculated by the Collection Agent under clause (a)(xii) of Section 3.5, in
     accordance with the terms of the Second Lien Documents and any applicable
     Board Resolution, including:

               (i) paying to such Persons as shall be specified by Royalty Sub
          such Transaction Expenses as shall be due and payable in connection
          with the issuance and sale of the applicable Class B Notes or
          Refinancing Notes;

               (ii) remitting to the Noteholders of such class of Notes, in
          accordance with the Board Resolution authorizing such Redemption, an
          amount equal to the Redemption Price plus Premium, if any, allocated,
          in the event of a Redemption of such Notes in part, pro rata in
          proportion to the Outstanding Principal Balance of such Notes held by
          such Noteholders; and

               (iii) making such other distributions and payments as shall be
          authorized and directed by the Board Resolution and supplemental
          indentures executed in connection with such Redemption.

     SECTION 3.10. Lilly Shortfall. If, no later than ten Business Days prior to
any Calculation Date, the Collection Agent receives written notice of the
existence of a Lilly Shortfall, the Collection Agent shall promptly (but in no
event later than the next succeeding Business Day following receipt of such
written notice) notify Servicer, Royalty Sub, Quintiles, the Trustee and the
First Lien Agent of such existence of a Lilly Shortfall. Upon Royalty Sub or
Quintiles receiving notification of the same, or upon Royalty Sub or Quintiles
otherwise becoming aware of a Lilly Shortfall, Royalty Sub shall cause Servicer,
no later than such Calculation Date, to confirm the amount of any such Lilly
Shortfall in writing to the Collection Agent, with a copy to Royalty Sub,
Quintiles, the Trustee and the First Lien Agent. Unless the Collection Agent
shall have received prior to the related Payment Date (i) written notification
from Quintiles or the Servicer certifying that any such Lilly Shortfall has been
cured in full, (ii) prior to the Discharge of First Lien Obligations, written
notice from the First Lien Agent that the Required Lenders have indicated that
such payment shall not be made on such Payment Date (with a copy of such notice
to the Trustee if not acting as Collection Agent) or (iii) following the
Discharge of First Lien Obligations, written notice from the Trustee that a
majority of the Outstanding Principal Balance of the Senior Class of Notes has
indicated that such payment shall not be made on such Payment Date, then prior
to making any other distributions pursuant to Section 3.7 or Section 3.8, the
Collection Agent shall make a Lilly Payment to Lilly on such Payment Date in the
amount of such Lilly Shortfall from the Holding Account and, to the extent funds
are not available in the Holding Account therefor, from the Collection Account.

     SECTION 3.11. Interest Coverage Ratio. On each Payment Date following the
Discharge of First Lien Obligations, after any transfers required by Section 3.6
have been made and any Lilly Payment has been made, the Collection Agent shall
transfer to Royalty Sub any amounts in the Holding Account on such Payment Date
if the Interest Coverage Ratio for such Payment Date and the Interest Coverage
Ratio for each of the three immediately preceding Payment Dates are equal to or
greater than the following specified ratios for each indicated Payment Date (as
determined pursuant to clause (a)(xv) of Section 3.5):

                                      -15-
<PAGE>
<TABLE>
<CAPTION>
                     Payment Dates                        Interest Coverage Ratio
                     -------------                        -----------------------
<S>                                                       <C>
From January 15, 2006 to and including October 15, 2006             1.5
From January 15, 2007 to and including October 15, 2007             2.0
From January 15, 2008 to and including October 15, 2008             3.0
From January 15, 2009 to and including October 15, 2009             4.0
From January 15, 2010 and thereafter                                5.0
</TABLE>

Notwithstanding the foregoing, the Collection Agent shall not make any such
transfer described in the immediately preceding paragraph if (i) an Event of
Default under the Indenture has occurred and is continuing, (ii) on or after
June 15, 2008, the Patent Extension Event has not occurred or (iii)(x) the
Trustee has received written notice from Noteholders of at least 25% of the
Outstanding Principal Balance of the Class A Notes that a Material Adverse
Development has occurred and (y) the Trustee has not received further written
notice from Noteholders of a majority of the Outstanding Principal Balance of
the Class A Notes that such Material Adverse Development has ended or is no
longer applicable; provided, that if the Person acting as Trustee is not the
same Person as the Collection Agent, the Trustee shall notify the Collection
Agent of the occurrence of such event.

     SECTION 3.12. Distributions. To the extent Royalty Sub receives amounts
from the Collection Agent distributed from the Collection Account pursuant to
clause (b)(x) of Section 3.7 or from the Holding Account pursuant to Section
3.11, such amounts may be distributed by Royalty Sub to the Pledgor (or as
otherwise directed by the Pledgor or any Person designated by the Pledgor to
give such directions) in its sole discretion.

     SECTION 3.13. Payments Over. Any Collateral or proceeds thereof received by
the Trustee or any Second Lien Claimholders in connection with the exercise of
any right or remedy (including setoff) relating to the Collateral in
contravention of this Agreement shall, to the extent permitted under Applicable
Law, be segregated and held in trust and forthwith paid over, without recourse,
representation or warranty, to the Collection Agent for the benefit of the First
Lien Agent and the First Lien Claimholders in the same form as received, with
any necessary endorsements or as a court of competent jurisdiction may otherwise
direct until such time as the Discharge of First Lien Obligations has occurred
and to the extent necessary to satisfy the Discharge of First Lien Obligations.
The Collection Agent and the First Lien Agent are hereby authorized to make any
such endorsements as agent for the Trustee or any such Second Lien Claimholders.
This authorization is coupled with an interest and is irrevocable.

     SECTION 3.14. Distribution Report. On each Payment Date, promptly following
receipt thereof by Servicer, the Collection Agent shall deliver to the First
Lien Agent and the Trustee a report in a form reasonably satisfactory to the
First Lien Agent and the Trustee, covering the items set forth in Annex B
hereto, prepared by Servicer and delivered to the Collection Agent pursuant to
the terms of the Servicing Agreement (each, a "Distribution Report"). Each
Distribution Report shall, pursuant to the terms of the Servicing Agreement, be
accompanied by (i) a statement prepared by Servicer setting forth an analysis of
the Collection Account activity for the period commencing on the day next
following the preceding Calculation Date and ending on the Calculation Date
relating to such Payment Date, (ii) such information, if any, that Quintiles
shall have provided to the First Lien Agent pursuant to Section 7.1.1 (or any
equivalent provision) of the First Lien Credit Agreement or to the Trustee
pursuant to Section 6.4 of the

                                      -16-
<PAGE>
Purchase and Sale Agreement during the Interest Accrual Period then ended and
(iii) the information, if any, that Royalty Sub shall have provided to the
Trustee pursuant to Section 5.2 of the Indenture, or Servicer shall have
provided to the Collection Agent pursuant to Section 4.1 of the Servicing
Agreement, during the period then ended.

     SECTION 3.15. Prior Payment of First Lien Obligations. Notwithstanding any
of the foregoing provisions of this Section 3, except in the case of a
Refinancing of the Second Lien Notes (or any Refinancing Notes in respect
thereof), in no event shall any amount of principal or premium with respect to
any Notes be paid, redeemed, discharged or otherwise satisfied prior to the
Discharge of First Lien Obligations without the prior written consent of the
First Lien Agent (it being understood that such payment, redemption, discharge
or other satisfaction may occur on the same Payment Date as the Discharge of
First Lien Obligations, provided the Discharge of First Lien Obligations has
occurred).

                             SECTION 4. ENFORCEMENT

     SECTION 4.1. Exercise of Remedies. At all times prior to the Discharge of
First Lien Obligations, whether or not any Insolvency or Liquidation Proceeding
has been commenced by or against any Obligor, subject to the other terms and
provisions of this Agreement, neither the Trustee nor the Second Lien
Claimholders (nor any representative or agent on their behalf) will exercise or
seek to exercise any rights or remedies (including setoff) available to them by
virtue of any Lien held by them with respect to any Collateral (including the
exercise of any right under any lockbox agreement, control account agreement or
similar agreement or arrangement to which the Trustee or any Second Lien
Claimholder is a party) or institute any action or proceeding with respect to
such rights or remedies (including any action of foreclosure), and will not
contest, protest or object to (or otherwise directly or indirectly hinder or
prevent) any Lien Enforcement Action or other action taken for the purpose of
protecting or preserving Collateral brought by the First Lien Agent or any First
Lien Claimholder with respect to the Collateral, or any other exercise by the
First Lien Agent or any First Lien Claimholder of any rights and remedies
relating to the Collateral, or object to the forbearance by the First Lien Agent
or the First Lien Claimholders from bringing or pursuing any Lien Enforcement
Action, other action taken for the purpose of protecting or preserving
Collateral, or any other exercise of any rights or remedies relating to the
Collateral, in each case so long as such proceeding, Lien Enforcement Action or
other right or remedy or forbearance thereof complies with Applicable Law and
this Agreement; provided, that if an Event of Default under the Indenture has
occurred and is continuing, subject at all times to the provisions of Section
2.1 and Section 3, commencing 180 days after receipt by the First Lien Agent of
a copy of (i) notice of such Event of Default to Royalty Sub and (ii) written
notice by the Trustee or the Second Lien Claimholders to Royalty Sub declaring
its or their intent to take action to enforce its or their Liens on the
Collateral (unless any Obligor is subject to an Insolvency or Liquidation
Proceeding by reason of which such declaration and the making of such demand is
stayed, in which case, commencing on the date of the commencement of such
Insolvency or Liquidation Proceeding), the Trustee or the Second Lien
Claimholders may take action to enforce its or their Liens on the Collateral,
but only so long as the First Lien Agent is not diligently pursuing in good
faith the exercise of its enforcement rights or remedies against, or diligently
attempting to vacate any stay or enforcement of its Liens on, any material part
of the Collateral (including commencement of any

                                      -17-
<PAGE>
reasonable action to foreclose its Liens on any material part of the Collateral,
any reasonable action to take possession of any material part of the Collateral
or commencement of any reasonable legal proceedings or actions to enforce its
Liens against or with respect to any material part of such Collateral) (prompt
notice of which shall be given to the Trustee as required pursuant to Section
6.1); provided, further, that (x) in any Insolvency or Liquidation Proceeding
commenced by or against any Obligor, the Trustee may file a claim or statement
of interest with respect to the Second Lien Obligations and (y) the Trustee may
take any action (not adverse to the Liens on the Collateral securing the First
Lien Obligations, or the rights of the First Lien Agent or the First Lien
Claimholders to exercise remedies in respect thereof) in order to preserve or
protect its Lien on the Collateral and to preserve its rights to share in the
proceeds of the Collateral in accordance with the terms of this Agreement. Prior
to the Discharge of First Lien Obligations, in any sale or other disposition of
any of the Collateral by the Trustee or any Second Lien Claimholder, (A) the
Trustee or such Second Lien Claimholder shall conduct such sale or other
disposition in a commercially reasonable manner and (B) any Collateral or
proceeds thereof received by the Trustee or such Second Lien Claimholders in
connection with such sale or other disposition shall, to the extent required
under Section 3 and to the extent permitted under Applicable Law, be segregated
and held in trust and forthwith paid over, without recourse, representation or
warranty, to the Collection Agent for application in accordance with Section 3
in the same form as received, with any necessary endorsements or as a court of
competent jurisdiction may otherwise direct. In exercising rights and remedies
with respect to the Collateral permitted hereunder, the First Lien Agent and the
First Lien Claimholders may enforce the provisions of the First Lien Documents
and exercise remedies thereunder and the Trustee and the Second Lien
Claimholders may enforce the provisions of the Second Lien Documents and
exercise remedies thereunder, in each case, all in such order and in such manner
as they may determine in the exercise of their sole discretion. Such exercise
and enforcement shall include the rights of an agent appointed by them to sell
or otherwise dispose of Collateral upon foreclosure, to incur expenses in
connection with such sale or disposition, and to exercise all the rights and
remedies of a secured creditor under the UCC and of a secured creditor under
Bankruptcy Laws.

     SECTION 4.2. Actions Not Subject to Limitation. Nothing in this Agreement
shall be construed to in any way limit or impair the right of: (a) any Secured
Creditor to bid for or purchase Collateral at any private or judicial
foreclosure upon such Collateral initiated by any Person; (b) the Trustee or any
Second Lien Claimholder to join (but not control) any Lien Enforcement Action or
other foreclosure or other judicial lien enforcement proceeding with respect to
the Collateral initiated by the First Lien Agent, so long as it does not delay
or interfere in any material respect with the exercise by the First Lien Agent
of its rights as provided in this Agreement; and (c) the Trustee to receive any
remaining proceeds of Collateral after the Discharge of First Lien Obligations.

                          SECTION 5. OTHER AGREEMENTS.

     SECTION 5.1. Releases. At all times prior to the Discharge of First Lien
Obligations and during the continuance of a Release Event, the Trustee and
Second Lien Claimholders shall, in connection with any contemplated sale or
other disposition of Collateral either by (A) the First Lien Agent or its agents
or (B) any Obligor with the consent of the First Lien Agent: (i) upon the
request of the First Lien Agent with respect to any of the Collateral (which
request shall specify

                                      -18-
<PAGE>
the proposed terms of such sale or other disposition and the type and amount of
consideration to be received in connection therewith), release or otherwise
terminate its Liens on such Collateral; (ii) promptly upon the request of the
First Lien Agent authorize, execute and/or deliver such release documents and
confirmations of the authorization to file UCC amendments and terminations
provided for herein, in each case as the First Lien Agent may reasonably require
in connection with such sale or other disposition; provided, that (A) subject to
the payment and Lien priorities established pursuant to this Agreement, such
release by the Trustee and Second Lien Claimholders shall not extend to or
otherwise affect any of the rights of the Trustee or Second Lien Claimholders
under this Agreement to the proceeds from any such sale or other disposition of
Collateral, (B) the First Lien Agent and First Lien Claimholders shall promptly
provide such proceeds to the Collection Agent for application in accordance with
Section 3, and (C) no such release and/or authorization documents shall be
required to be delivered by the Trustee and Second Lien Claimholders (1) to any
Obligor or (2) more than one Business Day prior to the date of the closing of
such sale or other disposition; provided further that, if the closing of such
sale or other disposition is not consummated, the First Lien Agent shall
promptly return all release and/or authorization documents to the Trustee and
Second Lien Claimholders, as the case may be; and (iii) be deemed to have
consented under the Second Lien Documents to such sale or other disposition, it
being understood, however, that the Trustee and Second Lien Claimholders shall,
subject to this Agreement, continue to have rights with respect to the proceeds
of such disposition constituting Collateral. The effectiveness of any such
release or termination by the Trustee and Second Lien Claimholders shall be
subject to the sale or other disposition of such Collateral described in such
request or on substantially similar terms and shall lapse in the event such sale
or other disposition does not occur within three days of the anticipated closing
date.

     SECTION 5.2. Insurance. At all times prior to the Discharge of First Lien
Obligations, the First Lien Agent and the First Lien Claimholders shall have the
sole and exclusive right, subject to the rights of the Obligors under the First
Lien Documents, to adjust settlement for any insurance policy covering the
Collateral in the event of any loss thereunder and to approve any award granted
in any condemnation or similar proceeding (or any deed in lieu of condemnation)
affecting the Collateral. Unless and until the Discharge of First Lien
Obligations has occurred, and subject to the rights of the Obligors under the
First Lien Collateral Documents, all proceeds of any such policy and any such
award (or any payments with respect to a deed in lieu of condemnation) in
respect of the Collateral shall be paid over to the Collection Agent for
application in accordance with Section 3, such other Person as may be entitled
thereto or as a court of competent jurisdiction may otherwise direct. If the
Trustee or any Second Lien Claimholders shall, at any time prior to the
Discharge of First Lien Obligations, receive any proceeds of any such insurance
policy or any such award or payment, it shall pay such proceeds over to the
Collection Agent for application in accordance with Section 3.

     SECTION 5.3. Amendments to First Lien Documents and Second Lien Documents.

     (a) Until the Discharge of First Lien Obligations, without the prior
written consent of the First Lien Agent, no Second Lien Document may be amended,
supplemented or otherwise modified to the extent such amendment, supplement or
modification would (i) contravene the provisions of this Agreement or clause (a)
of Section 7.2 of the First Lien Credit Agreement, (ii) increase the Outstanding
Principal Balance of the Second Lien Notes (including any Refinancing

                                      -19-
<PAGE>
Notes in respect thereof) to an amount in excess of the Outstanding Principal
Balance as of the Closing Date, together with interest that has been accrued and
unpaid under the Second Lien Notes (including any Refinancing Notes in respect
thereof) and, in the case of Refinancing Notes, any redemption premium provided
for in the Indenture and reasonable transaction expenses relating thereto, (iii)
increase the "Stated Rate of Interest" or similar component of the interest or
the yield on the Second Lien Notes or any Refinancing Notes above the Stated
Rate of Interest on the Second Lien Notes (or any Refinancing Notes in respect
thereof) as of the date hereof, (iv) provide for dates for payment of principal,
interest, premium (if any) or fees which are earlier than such dates under the
Indenture or the Second Lien Notes (or any Refinancing Notes in respect thereof)
as in effect on the date hereof, (v) provide for covenants, events of default or
remedies which are more restrictive in any material respect on any Obligor than
those set forth in the Indenture or the Note Purchase Agreements, in each case
as in effect on the date hereof, (vi) provide for redemption, prepayment or
defeasance provisions that are more burdensome in any material respect on any
Obligor than those set forth in the Indenture as in effect on the date hereof,
(vii) provide for collateral securing Secured Obligations thereunder which is
more extensive than the collateral provided for under the First Lien Documents
or (viii) increase the obligations of any Obligor or confer any additional
rights on any Second Lien Claimholder which would be adverse to the First Lien
Claimholders in any material respect.

     (b) Each of the Trustee, Royalty Sub and the Pledgor agrees that each
Second Lien Collateral Document shall include the following language (or
language to similar effect approved by the First Lien Agent):

          "Notwithstanding anything herein to the contrary, the Lien and
          security interest granted to the Trustee pursuant to this Agreement
          and the exercise of any right or remedy by the Trustee hereunder are
          subject to the provisions of the Intercreditor Agreement, dated as of
          October 18, 2005 (as amended, restated, supplemented or otherwise
          modified from time to time, the "Intercreditor Agreement"), among
          Morgan Stanley Senior Funding, Inc., as First Lien Agent, U.S. Bank
          National Association (or its successor), as trustee for the holders of
          the Second Lien Obligations, U.S. Bank National Association (or its
          successor), as Collection Agent, Duloxetine Royalty Sub, an exempted
          company with limited liability under the laws of the Cayman Islands,
          and Duloxetine Holdco Royalty Sub, an exempted company with limited
          liability under the laws of the Cayman Islands. In the event of any
          conflict between the terms of the Intercreditor Agreement and this
          Agreement, the terms of the Intercreditor Agreement shall govern and
          control."

     (c) Without the prior written consent of the Trustee, no First Lien
Document may be amended, supplemented or otherwise modified to the extent such
amendment, supplement or modification would (i) contravene the provisions of
this Agreement or Section 5.1(a) of the Indenture, (ii) increase the then
outstanding aggregate principal amount of the Loans under the First Lien Credit
Agreement in excess of the Maximum First Lien Principal Amount, (iii) increase
the "Applicable Margin" or similar component of the interest or the yield on the
Loans

                                      -20-
<PAGE>
under the First Lien Credit Agreement by more than 2.0% per annum above the
Applicable Margin on the Loans under the First Lien Credit Agreement as of the
Closing Date (exclusive, for the avoidance of doubt, of any imposition of up to
2.0% of "default" interest), or (iv) provide for a final stated maturity other
than the Final Maturity Date as in effect on the date hereof. The First Lien
Agent shall give notice of any amendment, waiver, consent or other modification
of any First Lien Document to the Trustee within ten (10) Business Days of the
effectiveness of such amendment, waiver, consent or other modification (provided
that the failure of any such notice to be given shall not impair or affect the
Trustee's or any Second Lien Claimholder's obligations to the First Lien Agent
and the First Lien Claimholders, the First Lien Agent's rights hereunder, the
enforceability of this Agreement or any Liens created or granted hereby or under
any First Lien Document or limit or impair the effectiveness or effect of any
such amendment, waiver or consent).

     (d) In the event the First Lien Agent or the First Lien Claimholders and
the relevant Obligor(s) enter into any amendment, waiver or consent in respect
of any of the First Lien Collateral Documents for the purpose of adding to, or
deleting from, or waiving or consenting to any departures from any provisions
of, any First Lien Collateral Document or changing in any manner the rights of
the First Lien Agent, the First Lien Claimholders, or any Obligor thereunder,
then such amendment, waiver or consent shall apply automatically to any
comparable provision of the Second Lien Collateral Documents without the consent
of the Trustee or the Second Lien Claimholders and without any action by the
Trustee or any Obligor; provided that (i) no such amendment, waiver or consent
shall have the effect of (A) removing assets subject to the Lien of the Second
Lien Collateral Documents, except to the extent that a release of such Lien is
permitted by Section 5.1 (or, for the avoidance of doubt, is expressly permitted
under the terms of the Second Lien Collateral Documents), (B) imposing duties on
the Trustee without its consent or (C) permitting other Liens on the Collateral
not permitted under the terms of Section 7 and (ii) notice of such amendment,
waiver or consent shall have been given to the Trustee within ten (10) Business
Days of the effectiveness of such amendment, waiver or consent (provided that
the failure of any such notice to be given shall not impair or affect the
Trustee's or any Second Lien Claimholder's obligations to the First Lien Agent
and the First Lien Claimholders, the First Lien Agent's rights hereunder, the
enforceability of this Agreement or any Liens created or granted hereby or under
any First Lien Document or limit or impair the effectiveness or effect of any
such amendment, waiver or consent or the automatic application thereof to any
comparable provision of the Second Lien Documents).

     SECTION 5.4. Rights As Unsecured Creditors. The Trustee and the Second Lien
Claimholders may exercise rights and remedies as unsecured creditors against the
Obligors in accordance with the terms of the Second Lien Documents and
Applicable Law. Except as otherwise set forth in this Agreement, nothing in this
Agreement shall prohibit the receipt by the Trustee or any Second Lien
Claimholders of payments in respect of the Second Lien Obligations, so long as
such receipt is (i) in accordance with all terms and provisions (including as to
priority of payments) of Section 3 and (ii) not the direct or indirect result of
the exercise by the Trustee or any Second Lien Claimholders of rights or
remedies available to them by virtue of any Lien or enforcement of any Lien, in
either case held by them, in contravention of this Agreement.

                                      -21-
<PAGE>
     SECTION 5.5. Agent for Perfection.

          (a) Each of the Agents, as applicable, acknowledges and agrees to
     hold, maintain control of or be listed as an additional insured or loss
     payee with respect to, the Pledged Collateral that is part of the
     Collateral in its possession, control or with respect to which it is listed
     as an additional insured or loss payee (or in the possession or control of
     its agents or bailees) as agent for the benefit of the First Lien Agent and
     the Trustee and any assignee solely for the purpose of perfecting the
     security interest granted under the First Lien Collateral Documents and the
     Second Lien Collateral Documents, subject to the terms and conditions of
     this Section 5.5.

          (b) Except to the extent otherwise provided under Section 3 or Section
     4.1 and until the Discharge of First Lien Obligations has occurred, the
     First Lien Agent and the Collection Agent, as applicable, shall be entitled
     to deal with the Pledged Collateral in accordance with the terms of the
     First Lien Collateral Documents as if the Liens of the Trustee under the
     Second Lien Collateral Documents did not exist. The rights of the Trustee
     shall at all times be subject to the terms of this Agreement and to the
     First Lien Agent's rights under the First Lien Collateral Documents.

          (c) Each of the First Lien Agent and the Trustee hereby appoints the
     other and the Collection Agent as its agent and representative, solely for
     the purpose of perfecting the Lien granted in the Collateral to such First
     Lien Agent, the Trustee or the Collection Agent, with respect to any
     financing statements, security agreements and any other documentation filed
     from time to time naming such other as secured party with respect to the
     Collateral and which is required to be filed in order to perfect the Lien
     of such other Person on the Collateral under Applicable Law ("Filing
     Collateral"), and each of the First Lien Agent, the Trustee and the
     Collection Agent hereby accepts such appointment and agrees to hold such
     financing statements, security agreements and any other documentation in
     such capacity solely for the purpose of perfecting the Lien granted in the
     Collateral to such other Person.

          (d) The First Lien Agent and the Collection Agent shall have no
     obligation whatsoever to the Trustee or any Second Lien Claimholder to
     assure that the Pledged Collateral or the Filing Collateral is genuine or
     owned by any Obligor or to preserve rights or benefits of any Person except
     as expressly set forth in this Section 5.5. The duties or responsibilities
     of the First Lien Agent and the Collection Agent under this Section 5.5
     shall be limited solely to holding the Pledged Collateral as agent for the
     First Lien Agent and the Trustee and acting as agent and representative
     with respect to the Filing Collateral, in each case, in accordance with
     this Section 5.5. The Trustee shall have no obligation whatsoever to the
     Collection Agent, the First Lien Agent or any First Lien Claimholder to
     assure that the Filing Collateral is genuine or owned by any Obligor or to
     preserve rights or benefits of any Person except as expressly set forth in
     this Section 5.5. The duties or responsibilities of the Trustee under this
     Section 5.5 shall be limited solely to acting as agent and representative
     with respect to the Filing Collateral in accordance with this Section 5.5.

                                      -22-
<PAGE>
          (e) The Collection Agent and the First Lien Agent shall not have by
     reason of the Second Lien Collateral Documents, this Agreement or any other
     document, or its acceptance of the appointment set forth in clause (c)
     above, a fiduciary relationship or any other obligations or liabilities in
     respect of the Trustee or any Second Lien Claimholder. The Collection Agent
     and the Trustee shall not have by reason of the First Lien Collateral
     Documents, this Agreement or any other document, or its acceptance of the
     appointment set forth in clause (c) above, a fiduciary relationship or any
     other obligations or liabilities in respect of the First Lien Agent or any
     First Lien Claimholder.

          (f) Upon the Discharge of First Lien Obligations, the First Lien Agent
     or the Collection Agent, as applicable, shall deliver, without recourse,
     representation or warranty, the remaining Pledged Collateral (if any)
     together with any necessary endorsements to the Trustee for its benefit and
     that of the Second Lien Claimholders, at the sole cost and expense of such
     holders to the extent Second Lien Obligations remain outstanding, in each
     case, so as to allow such Person to obtain possession or control of, or (if
     applicable) be listed as an additional insured or loss payee with respect
     to, such Pledged Collateral in accordance with the UCC or other Applicable
     Law. Upon such Discharge of the First Lien Obligations, the First Lien
     Agent and the Collection Agent further agree to take all other action
     reasonably requested by the Trustee, at the sole cost and expense of the
     Second Lien Claimholders, in connection with the Trustee obtaining a
     first-priority interest in the Collateral or as a court of competent
     jurisdiction may otherwise direct including the establishment of the
     Accounts in the name of the Trustee.

     SECTION 5.6. Consent Under Purchase and Sale Agreement, Servicing Agreement
or Second Lien Pledge and Security Agreement. So long as no Event of Default
under the First Lien Credit Agreement has occurred and is continuing, the First
Lien Agent and the First Lien Claimholders agree that the First Lien Agent will
not, without the prior written consent of the Trustee, (i) consent to any
amendment, waiver, modification, restatement or supplement of the Purchase and
Sale Agreement under Section 6.2, 9.6 or 9.8 thereof, (ii) consent to any
amendment, waiver, modification, restatement or supplement of the Servicing
Agreement under Section 6.4 or 6.6 thereof, or exercise its rights under Section
4.1 thereof to replace the Servicer, or exercise any consent rights under
Section 6.6 of the Servicing Agreement, (iii) exercise any consent rights under
Section 6.1(l) or 9.8 of the Purchase and Sale Agreement or (iv) exercise any
consent rights under Section 6.1, 6.5, 6.9 or 6.10 of the Second Lien Pledge and
Security Agreement.

              SECTION 6. SECOND LIEN CLAIMHOLDERS PURCHASE OPTION.

     SECTION 6.1. Notice of Exercise. The First Lien Agent shall give the
Trustee prior written notice (a "Trigger Notice") of its intention to either (i)
require the Second Lien Claimholders to release their Lien on Collateral
pursuant to the terms hereof during the continuance of a Release Event or (ii)
take any Lien Enforcement Action or other action taken for the purpose of
protecting or preserving Collateral under the First Lien Documents (including
written notice to Quintiles of a Liquidated Damages Event, unless the Trustee
has given a notice to Quintiles of a Liquidated Damages Event under Section 8.2
of the Purchase and Sale Agreement that has not been rescinded by the First Lien
Agent pursuant to the terms of such Section 8.2, in which case no Trigger Notice
shall be required), together with a description in

                                      -23-
<PAGE>
reasonable detail as to the Lien Enforcement Action or such other action it
intends to take. The First Lien Agent shall give such Trigger Notice (x) in the
absence of an Exigent Circumstance, not less than ten Business Days prior to the
taking of any such Lien Enforcement Action or other action taken for the purpose
of protecting or preserving Collateral under the First Lien Documents or (b) if
Exigent Circumstances exist, as soon as practicable and in any event
contemporaneously with the taking of such Lien Enforcement Action or such other
action. The Trustee, on behalf of the Second Lien Claimholders who elect to so
participate pursuant to the Indenture (the "Participating Second Lien
Claimholders"), shall then have the option, exercised by delivery of notice to
the First Lien Agent on behalf of the First Lien Claimholders (the "Purchase
Notice") within ten Business Days following receipt of such Trigger Notice, to
purchase all of the First Lien Obligations from the First Lien Claimholders.
Such notice from the Trustee to the First Lien Agent shall be irrevocable. In
the event that during such ten Business Day period, the Trustee shall send to
the First Lien Agent a Purchase Notice, the First Lien Agent shall not commence
any Lien Enforcement Action or other foreclosure or other action to sell or
otherwise realize upon the Collateral; provided, that continuing collection of
amounts to be paid to or on behalf of the First Lien Claimholders under the
terms of Section 3 shall not be prohibited hereunder; provided further that the
purchase and sale with respect to the First Lien Obligations provided for herein
shall have closed within five Business Days after receipt by the First Lien
Agent of such Purchase Notice and the First Lien Agent shall have received
payment in full of the First Lien Obligations as provided for herein within such
five Business Day period.

     SECTION 6.2. Purchase and Sale. On the date specified by the Trustee in
such Purchase Notice (which shall not be less than three Business Days nor more
than five Business Days after the receipt by the First Lien Agent of the
Purchase Notice from the Trustee), the First Lien Claimholders shall sell to the
Trustee (for the account of the Participating Second Lien Claimholders), and the
Trustee shall purchase (on behalf of the Participating Second Lien Claimholders)
from the First Lien Claimholders, the First Lien Obligations; provided, that the
First Lien Agent and the First Lien Claimholders shall retain all rights to be
indemnified or held harmless by the Obligors in accordance with the terms of the
First Lien Documents but shall not retain any rights to the security therefor.

     SECTION 6.3. Payment of Purchase Price. Upon the date of such purchase and
sale, the Trustee shall (a) pay to the First Lien Agent on behalf of the First
Lien Claimholders as the purchase price therefor the full amount of all the
First Lien Obligations then outstanding and unpaid (including principal,
interest, fees and expenses, including reasonable attorneys' fees and legal
expenses) and (b) agree to reimburse the First Lien Claimholders for any loss,
cost, damage or expense (including reasonable attorney's fees and legal
expenses) in connection with any checks or other payments provisionally credited
to the First Lien Obligations as to which any First Lien Claimholder has not yet
received final payment. Such purchase price shall be remitted by wire transfer
in federal funds to such bank account of the First Lien Agent in New York City
as the First Lien Agent may designate in writing to the Trustee for such
purpose. Interest shall be calculated to but excluding the Business Day on which
such purchase and sale shall occur if the amounts so paid by the Trustee to the
bank account designated by the First Lien Agent are received in such bank
account prior to 2:00 p.m., New York City time and interest shall be calculated
to and including such Business Day if the amounts so paid by the Trustee to the
bank

                                      -24-
<PAGE>
account designated by the First Lien Agent are received in such bank account
later than 2:00 p.m., New York City time.

     SECTION 6.4. Limitation on Representations and Warranties. Such purchase
shall be expressly made without representation or warranty of any kind by the
First Lien Agent or any First Lien Claimholder as to the First Lien Obligations
or otherwise and without recourse to the First Lien Agent or any First Lien
Claimholder, except that each First Lien Claimholder shall represent and warrant
(a) the amount of its portion of the First Lien Obligations being purchased, (b)
that such First Lien Claimholder owns its portion of the First Lien Obligations
free and clear of any Liens or encumbrances and (c) such First Lien Claimholder
has the right to assign such First Lien Obligations and the assignment is duly
authorized.

                SECTION 7. INSOLVENCY OR LIQUIDATION PROCEEDINGS.

     SECTION 7.1. Finance Issues.

          (a) If any Obligor shall become subject to any Insolvency or
     Liquidation Proceeding and if as debtor(s)-in-possession move for approval
     of financing to be provided in good faith by any Secured Creditor (the "DIP
     Lender") under Section 364 of the Bankruptcy Code or the use of cash
     collateral with the consent of the DIP Lender under Section 363 of the
     Bankruptcy Code (each a "DIP Financing"), no other Secured Creditor shall
     object to any such financing or use of cash collateral on any grounds
     whatsoever, other than on the grounds of a failure to provide "adequate
     protection" for the Liens of such other Secured Creditor, so long as (i)
     the interest rate, fees, advance rates, lending sublimits and limits and
     other terms are commercially reasonable under the circumstances, (ii)
     except as provided in the immediately succeeding sentence, all such other
     Secured Creditors retain a Lien on the Collateral (including proceeds
     thereof arising after the commencement of such proceeding) with the same
     priority as existed prior to the commencement of the case under the
     Bankruptcy Code, and (iii) such financing or use of cash collateral is
     subject to the terms of this Agreement. To the extent the Liens securing
     the First Lien Obligations are subordinated or pari passu with such DIP
     Financing, the Trustee and each Second Lien Claimholder will subordinate
     its Liens in the Collateral to the Liens securing such DIP Financing (and
     all Obligations relating thereto).

          (b) If any Obligor shall be subject to any Insolvency or Liquidation
     Proceeding and the First Lien Agent shall desire to permit Royalty Sub or
     the Pledgor to sell, lease or otherwise dispose of Collateral free and
     clear of the Liens securing the First Lien Obligations or other claims
     under Section 363 of the Bankruptcy Code, then the Trustee, on behalf of
     itself and the Second Lien Claimholders, agrees that it will raise no
     objection to such sale, lease or other disposition of Collateral; provided
     that the net cash proceeds of such sale, lease or other disposition are
     applied in accordance with the terms of Section 3.

     SECTION 7.2. Relief from the Automatic Stay. Until the Discharge of First
Lien Obligations has occurred, the Trustee, on behalf of itself and the Second
Lien Claimholders, agrees that none of them shall seek relief from the automatic
stay or any other stay in any Insolvency or Liquidation Proceeding in respect of
the Collateral (except, if the First Lien Agent,

                                      -25-
<PAGE>
on behalf of itself and the First Lien Claimholders, seeks relief from the
automatic stay to exercise their rights against the Collateral under and in
accordance with this Agreement, then the Trustee, on behalf of itself and the
Second Lien Claimholders, may seek limited relief from the automatic stay to
preserve its or their right, subject to Section 5, to receive proceeds of
Collateral payable to them under and in accordance with this Agreement), without
the prior written consent of the First Lien Agent.

     SECTION 7.3. Adequate Protection. The Trustee, on behalf of itself and the
Second Lien Claimholders, agrees that neither it nor any Second Lien Claimholder
shall contest (or support any other Person contesting) (i) any request by the
First Lien Agent or the First Lien Claimholders for adequate protection or (ii)
any objection by the First Lien Agent or the First Lien Claimholders to any
motion, relief, action or proceeding based on the First Lien Agent or the First
Lien Claimholders claiming a lack of adequate protection, except as provided in
Section 7.1. Notwithstanding the foregoing provisions in this Section 7.3 but
subject to the provisions of Section 7.1, in any Insolvency or Liquidation
Proceeding, (x) if the First Lien Claimholders (or any subset thereof) are
granted adequate protection in the form of additional collateral securing the
First Lien Obligations and any DIP Financing provided by the First Lien
Claimholders, then the Trustee, on behalf of itself or any of the Second Lien
Claimholders, shall also be granted a second priority Lien on such additional
collateral as security for the Second Lien Obligations, and any Lien on such
additional collateral securing the Second Lien Obligations shall be subordinated
or otherwise second in priority to the Liens on such collateral securing the
First Lien Obligations and any such DIP Financing provided by the First Lien
Claimholders (and all obligations relating thereto) and to any other Liens
granted to the First Lien Claimholders as adequate protection on the same basis
as the other Liens securing the Second Lien Obligations are subordinated or
otherwise second in priority to such First Lien Obligations under this
Agreement; and (y) in the event the Trustee, on behalf of itself and the Second
Lien Claimholders, seeks or requests adequate protection in respect of Second
Lien Obligations and such adequate protection is granted in the form of
additional collateral, then the Trustee, on behalf of itself or any of the
Second Lien Claimholders, agrees that the First Lien Agent (or its agent) shall
also be granted a senior Lien on such additional collateral as security for the
First Lien Obligations and for any such DIP Financing provided by the First Lien
Claimholders and that any Lien on such additional collateral securing the Second
Lien Obligations shall be subordinated or otherwise second in priority to the
Liens on such collateral securing the First Lien Obligations and any such DIP
Financing provided by the First Lien Claimholders (and all obligations relating
thereto) and to any other Liens granted to the First Lien Claimholders as
adequate protection on the same basis as the other Liens securing the Second
Lien Obligations are subordinated or otherwise second in priority to such First
Lien Obligations under this Agreement.

     SECTION 7.4. Preference Issues. If the First Lien Agent or any First Lien
Claimholder is required in any Insolvency or Liquidation Proceeding or otherwise
to turn over or otherwise pay to the estate of any Obligor any amount (a
"Recovery"), then the First Lien Obligations shall be reinstated to the extent
of such Recovery and the First Lien Agent and the First Lien Claimholders shall
be entitled to a reinstatement of First Lien Obligations with respect to all
such recovered amounts. If this Agreement shall have been terminated prior to
such Recovery, this Agreement shall be reinstated in full force and effect, and
such prior termination shall not

                                      -26-
<PAGE>
diminish, release, discharge, impair or otherwise affect the obligations of the
parties hereto from such date of reinstatement.

     SECTION 7.5. No Waiver. The First Lien Agent and the First Lien
Claimholders shall not be prohibited or in any way limited from objecting in any
Insolvency or Liquidation Proceeding or otherwise (except to the extent it is
expressly agreed herein that no such objection shall be made) to any action
taken by the Trustee or any of the Second Lien Claimholders, including the
seeking by the Trustee or any Second Lien Claimholder of adequate protection or
the asserting by the Trustee or any Second Lien Claimholders of any of its
rights and remedies under the Second Lien Documents.

     SECTION 7.6. Reorganization Securities. If, in any Insolvency or
Liquidation Proceeding, debt instruments or securities of the reorganized debtor
secured by Liens upon any property of the reorganized debtor are distributed,
pursuant to a court-authorized plan of reorganization or similar
court-authorized dispositive restructuring plan, both on account of First Lien
Obligations and on account of Second Lien Obligations, then (x) the Second Lien
Claimholders will be allowed to retain such securities notwithstanding any
provision herein to the contrary and (y) to the extent the debt instruments or
securities distributed on account of the First Lien Obligations and on account
of the Second Lien Obligations are secured by Liens upon the same property, the
provisions of this Agreement will survive the distribution of such debt
instruments or securities pursuant to such plan and will apply with like effect
to the Liens securing such debt instruments or securities, unless otherwise
agreed by the First Lien Claimholders and the Second Lien Claimholders.

     SECTION 7.7. Voting for Plan of Reorganization. The First Lien
Claimholders, on the one hand, and the Second Lien Claimholders, on the other
hand, shall be entitled to vote as separate classes with respect to any plan of
reorganization in connection with any Insolvency or Liquidation Proceeding;
provided, however, that the Trustee, on behalf of itself and the Second Lien
Claimholders, agrees that neither it nor any Second Lien Claimholder shall take
any action or vote in any way which supports any plan of reorganization that is
inconsistent with the terms of this Agreement.

     SECTION 7.8. Effectiveness in Insolvency or Liquidation Proceedings. This
Agreement, which the parties hereto expressly acknowledge is a "subordination
agreement" under Section 510(a) of the Bankruptcy Code, shall, for the avoidance
of any doubt, be effective before, during and after the commencement of an
Insolvency or Liquidation Proceeding. All references in this Agreement to an
Obligor shall include such Obligor, as applicable, as a debtor-in-possession and
any receiver or trustee for such Obligor, as applicable, in any Insolvency or
Liquidation Proceeding.

     SECTION 7.9. Post-Petition Interest.

          (a) Neither the Trustee nor any Second Lien Claimholder shall oppose
     or seek to challenge any claim by the First Lien Agent or any First Lien
     Claimholder for allowance in any Insolvency or Liquidation Proceeding of
     First Lien Obligations consisting of post-petition interest, fees or
     expenses to the extent of the value of the Lien of the First Lien Agent on
     behalf of the First Lien Claimholders on the Collateral without regard to
     the

                                      -27-
<PAGE>
     existence of the Lien of the Trustee on behalf of the Second Lien
     Claimholders on the Collateral.

          (b) Neither the First Lien Agent nor any First Lien Claimholder shall
     oppose or seek to challenge any claim by the Trustee or any Second Lien
     Claimholder for allowance in any Insolvency or Liquidation Proceeding of
     Second Lien Obligations consisting of post-petition interest, fees or
     expenses to the extent of the value of the Lien of the Trustee on behalf of
     the Second Lien Claimholders on the Collateral, after taking into account
     the Lien of the First Lien Agent on behalf of the First Lien Claimholders
     on the Collateral.

                       SECTION 8. RELIANCE; WAIVERS; ETC.

     SECTION 8.1. Reliance. Other than any reliance on the terms of this
Agreement, the First Lien Agent, on behalf of itself and the First Lien
Claimholders, acknowledges that it and such First Lien Claimholders have,
independently and without reliance on the Trustee or any Second Lien
Claimholders, and based on documents and information deemed by them appropriate,
made their own credit analysis and decision to enter into each of the First Lien
Documents and be bound by the terms of this Agreement and they will continue to
make their own credit decision in taking or not taking any action under the
First Lien Documents or this Agreement. Other than any reliance on the terms of
this Agreement, the Trustee, on behalf of itself and such Second Lien
Claimholders, acknowledges that it and such Second Lien Claimholders have,
independently and without reliance on the First Lien Agent or any First Lien
Claimholders, and based on documents and information deemed by them appropriate,
made their own credit analysis and decision to enter into each of the Second
Lien Documents and be bound by the terms of this Agreement and they will
continue to make their own credit decision in taking or not taking any action
under the Second Lien Documents or this Agreement.

     SECTION 8.2. No Warranties or Liability. The First Lien Agent, on behalf of
itself and the First Lien Claimholders, acknowledges and agrees that each of the
Trustee and the Second Lien Claimholders have made no express or implied
representation or warranty, including with respect to the execution, validity,
legality, completeness, collectibility or enforceability of any of the Second
Lien Documents, the ownership of any Collateral or the perfection or priority of
any Liens thereon. The Second Lien Claimholders will be entitled to manage and
supervise their respective rights and obligations under the Second Lien
Documents in accordance with law and as they may otherwise, in their sole
discretion, deem appropriate, but subject in all respects to this Agreement. The
Trustee, on behalf of itself and the Second Lien Claimholders, acknowledges and
agrees that each of the First Lien Agent and the First Lien Claimholders have
made no express or implied representation or warranty, including with respect to
the execution, validity, legality, completeness, collectibility or
enforceability of any of the First Lien Documents, the ownership of any
Collateral or the perfection or priority of any Liens thereon. Except as may be
specifically set forth in this Agreement, the First Lien Claimholders will be
entitled to manage and supervise their respective rights and obligations under
the First Lien Documents in accordance with law and as they may otherwise, in
their sole discretion, deem appropriate (including without regard to the rights
and interests of the Second Lien Claimholders). The Trustee and the Second Lien
Claimholders shall have no duty to the First Lien Agent or any of the First Lien
Claimholders, and the First Lien Agent and the First Lien

                                      -28-
<PAGE>
Claimholders shall have no duty to the Trustee or any of the Second Lien
Claimholders, to act or refrain from acting in a manner which allows, or results
in, the occurrence or continuance of an event of default or default under any
agreements with any Obligor (including the First Lien Documents and the Second
Lien Documents), regardless of any knowledge thereof which they may have or be
charged with.

     SECTION 8.3. No Waiver of Lien Priorities.

          (a) No right of the Collection Agent, the First Lien Claimholders, the
     First Lien Agent or any of them to enforce any provision of this Agreement
     or any First Lien Document shall at any time in any way be prejudiced or
     impaired by any act or failure to act on the part of any Obligor or by any
     act or failure to act by any First Lien Claimholder or the First Lien
     Agent, or by any noncompliance by any Person with the terms, provisions and
     covenants of this Agreement, any of the First Lien Documents or any of the
     Second Lien Documents, regardless of any knowledge thereof which the First
     Lien Agent or the First Lien Claimholders, or any of them, may have or be
     otherwise charged with. No right of the Collection Agent, the Trustee, the
     Second Lien Claimholders or any of them to enforce any provision of this
     Agreement or any Second Lien Document shall at any time in any way be
     prejudiced or impaired by any act or failure to act on the part of any
     Obligor or by any act or failure to act by any Second Lien Claimholder or
     the Trustee, or by any noncompliance by any Person with the terms,
     provisions and covenants of this Agreement, any of the Second Lien
     Documents or any of the First Lien Documents, regardless of any knowledge
     thereof which the Trustee or the Second Lien Claimholders, or any of them,
     may have or be otherwise charged with.

          (b) Without in any way limiting the generality of the foregoing
     paragraph (but subject to the rights of any Obligor under the First Lien
     Documents), the Collection Agent (as applicable), the First Lien
     Claimholders, the First Lien Agent and any of them may, at any time and
     from time to time in accordance with the First Lien Documents and/or
     Applicable Law, without the consent of, or notice to, the Trustee or any
     Second Lien Claimholders, without incurring any liabilities to the Trustee
     or any Second Lien Claimholders and without impairing or releasing the Lien
     priorities and other benefits provided in this Agreement (even if any right
     of subrogation or other right or remedy of the Trustee or any Second Lien
     Claimholders is affected, impaired or extinguished thereby) do any one or
     more of the following:

               (i) except as set forth in Section 5.3, change the manner, place
          or terms of payment or change or extend the time of payment of, or
          amend, renew, exchange, or (subject to Section 2.1) increase or alter,
          the terms of any of the First Lien Obligations or any Lien on any
          Collateral or any liability of any Obligor, or any liability incurred
          directly or indirectly in respect thereof (including any increase in
          or extension of the First Lien Obligations, without any restriction as
          to the amount, tenor or terms of any such increase or extension) or
          otherwise amend, renew, exchange, extend, modify or supplement in any
          manner any Liens held by the First Lien Agent or any of the First Lien
          Claimholders, the First Lien Obligations or any of the First Lien
          Documents;

                                      -29-
<PAGE>
               (ii) subject to the terms of this Agreement, sell, exchange,
          release, surrender, realize upon, enforce or otherwise deal with in
          any manner and in any order any part of the Collateral or any
          liability of any Obligor to the First Lien Claimholders or the First
          Lien Agent, or any liability incurred directly or indirectly in
          respect thereof;

               (iii) subject to Section 2.1, take or fail to take any Lien or
          any other collateral security for any First Lien Obligations or take
          or fail to take any action which may be necessary or appropriate to
          ensure that any such Lien or any other Lien upon any property is duly
          enforceable or perfected or entitled to priority as against any other
          Lien or to ensure that any proceeds of any property subject to any
          Lien are applied to the payment of any First Lien Obligations or any
          other obligation secured thereby;

               (iv) settle or compromise any First Lien Obligation or any other
          liability of any Obligor or any security therefor or any liability
          incurred directly or indirectly in respect thereof and, subject to the
          terms of Section 3, apply any sums by whomsoever paid and however
          realized to any liability (including the First Lien Obligations) in
          any manner or order; and

               (v) subject to the terms of this Agreement, exercise or delay in
          or refrain from exercising any right or remedy against any Obligor or
          any other Person, elect any remedy and otherwise deal freely with any
          Obligor or any Collateral and any security or any liability of any
          Obligor to the First Lien Claimholders or any liability incurred
          directly or indirectly in respect thereof.

          (c) The Trustee, on behalf of itself and the Second Lien Claimholders,
     agrees that the Collection Agent, the First Lien Claimholders and the First
     Lien Agent shall have no liability to the Trustee or any Second Lien
     Claimholders, and the Trustee, on behalf of itself and the Second Lien
     Claimholders, hereby waives any claim any such Person may have against any
     First Lien Claimholder or the First Lien Agent, in each case arising out of
     any and all actions which the First Lien Claimholders or the First Lien
     Agent (or any of their respective affiliates, directors, officers,
     employees, agents and other representatives) may take or permit or omit to
     take with respect to (i) the First Lien Documents, (ii) the collection, or
     the exercise of rights and remedies in respect, of the First Lien
     Obligations or (iii) the foreclosure upon, or sale, liquidation or other
     disposition of, or transaction relating to, any Collateral; provided, that
     any such action is taken in a commercially reasonable manner and in
     accordance with Applicable Law and this Agreement. The Trustee, on behalf
     of itself and the Second Lien Claimholders, agrees that the First Lien
     Claimholders and the First Lien Agent have no duty to them in respect of
     the maintenance or preservation of the Collateral, the First Lien
     Obligations or otherwise, except as provided in this Agreement. Neither the
     Collection Agent, the First Lien Agent nor any First Lien Claimholder nor
     any of their respective directors, officers, employees, agents or other
     representatives will be liable for failure to demand, collect or realize
     upon any of the Collateral or for any delay in doing so, except to the
     extent arising out of the breach of this Agreement by any such Person, and
     will be under no obligation to sell or otherwise dispose of any Collateral
     upon the request of any Obligor or upon the

                                      -30-
<PAGE>
     request of any Second Lien Claimholder or any other Person or to take any
     other action whatsoever with regard to the Collateral or any part thereof.

          (d) The Trustee, on behalf of itself and the Second Lien Claimholders,
     agrees not to assert and hereby waives, to the fullest extent permitted by
     law, any right to demand, request, plead or otherwise assert or otherwise
     claim the benefit of, any marshalling, appraisal, valuation or other
     similar right that may otherwise be available under Applicable Law with
     respect to the Collateral or any other similar rights a junior secured
     creditor may have under Applicable Law. The Trustee and the Second Lien
     Claimholders waive any claim or defense which any or all of them may now or
     hereafter have against the First Lien Agent or the First Lien Claimholders
     arising out of any and all actions which the First Lien Agent or the First
     Lien Claimholders take or omit to take (including actions with respect to
     the creation, perfection or continuation of liens or security interests in
     any Collateral, actions with respect to the occurrence of any default or
     event of default, actions with respect to the foreclosure upon, sale,
     release of, depreciation of or failure to realize upon, any Collateral and
     actions with respect to the collection of any claim for all or any part of
     the First Lien Obligations from Royalty Sub, the Pledgor or any other
     party) with respect to the First Lien Documents but in any event not in
     contravention of this Agreement.

     SECTION 8.4. Obligations Unconditional. All rights, interests, agreements
and obligations of the First Lien Agent and the First Lien Claimholders and the
Trustee and the Second Lien Claimholders, respectively, hereunder shall remain
in full force and effect irrespective of:

          (a) any lack of validity or enforceability of any First Lien Documents
     or any Second Lien Documents or the Liens granted thereunder;

          (b) any change in the time, manner or place of payment of, or in any
     other terms of, all or any of the First Lien Obligations or Second Lien
     Obligations, or any amendment or waiver or other modification, including
     any increase in the amount thereof, whether by course of conduct or
     otherwise, of the terms of any First Lien Document or any Second Lien
     Document (except to the extent otherwise prohibited by this Agreement);

          (c) any exchange of any security interest in any Collateral or any
     other collateral, or any amendment, waiver or other modification, whether
     in writing or by course of conduct or otherwise, of all or any of the First
     Lien Obligations or Second Lien Obligations;

          (d) the commencement of any Insolvency or Liquidation Proceeding in
     respect of any Obligor; or

          (e) any other circumstances which otherwise might constitute a defense
     available to, or a discharge of, any Obligor in respect of the First Lien
     Obligations, or of the Trustee or any Second Lien Claimholder in respect of
     this Agreement.

                                      -31-
<PAGE>
                            SECTION 9. MISCELLANEOUS.

     SECTION 9.1. Collection Agent. U.S. Bank National Association shall act as
the initial Collection Agent hereunder. The First Lien Agent (and, following the
Discharge of First Lien Obligations, the Trustee) may, upon written notice to
the Collection Agent, appoint any other Person (including the First Lien Agent
or the Trustee) to be the successor Collection Agent. Upon receipt of such
notice that a successor Collection Agent has been appointed, the existing
Collection Agent shall resign as Collection Agent and shall cooperate in good
faith to cause the successor to become the new Collection Agent and shall take
such actions as may be necessary or desirable to effect such change in the
identity of the Collection Agent, including transferring the Accounts (or any
other Collateral) into the name of the successor Collection Agent. The
Collection Agent may resign upon 30 days written notice to the First Lien Agent
and the Trustee (or such shorter period as may be required to appoint a
successor Collection Agent as set forth above). Neither the Collection Agent nor
any of its directors, officers, employees or agents shall be liable to any
Secured Creditor for any action taken or omitted to be taken by it under any
First Lien Document or Second Lien Document, or in connection therewith, except
for its own willful misconduct or gross negligence, nor responsible for any
recitals or warranties herein or therein, nor for the effectiveness,
enforceability, validity or due execution of any First Lien Document or Second
Lien Document, nor for the creation, perfection or priority of any Liens
purported to be created by any of the First Lien Documents or Second Lien
Documents, or the validity, genuineness, enforceability, existence, value or
sufficiency of any collateral security, nor to make any inquiry respecting the
performance by any Obligor of its obligations. Any such inquiry which may be
made by the Collection Agent shall not obligate it to make any further inquiry
or to take any action. The Collection Agent shall be entitled to rely upon
advice of counsel concerning legal matters and upon any notice, consent,
certificate, statement or writing which the Collection Agent believes to be
genuine and to have been presented by a proper Person.

     SECTION 9.2. Reliance by Collection Agent. The Collection Agent shall be
entitled to rely upon any certification, notice or other communication
(including any thereof by telephone, telecopy, telegram or cable) believed by it
to be genuine and correct and to have been signed or sent by or on behalf of the
proper Person, and upon advice and statements of legal counsel, independent
accountants and other experts selected by any Agent. As to any matters not
expressly provided for by this Agreement, the Collection Agent shall in all
cases be fully protected in acting, or in refraining from acting, in accordance
with instructions given by the other Agents as required in such circumstance.

     SECTION 9.3. Conflicts. In furtherance of Section 5.3, in the event of any
conflict between the provisions of this Agreement and the provisions of the
First Lien Documents or the Second Lien Documents, the provisions of this
Agreement shall govern and control.

     SECTION 9.4. Effectiveness; Continuing Nature of this Agreement;
Severability. This Agreement shall become effective when executed and delivered
by the parties hereto. This is a continuing agreement of Lien subordination and
the First Lien Claimholders may continue, at any time and without notice to the
Trustee or any Second Lien Claimholder, subject to the provisions of this
Agreement, to extend credit and other financial accommodations and lend monies
to or for the benefit of any Obligor constituting First Lien Obligations in
reliance hereof

                                      -32-
<PAGE>
and subject to the terms hereof. The Trustee, on behalf of itself and the Second
Lien Claimholders, hereby waives any right it may have under Applicable Law to
revoke this Agreement or any of the provisions of this Agreement. Any provision
of this Agreement which is prohibited or unenforceable in any jurisdiction shall
not invalidate the remaining provisions hereof, and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction. Subject to Section 7.4,
this Agreement shall terminate and be of no further force and effect, (i) with
respect to the Trustee, the Second Lien Claimholders and the Second Lien
Obligations, upon the later of (x) the date upon which the Secured Obligations
under the Indenture terminate if there are no other Second Lien Obligations
outstanding on such date and (y) if there are other Second Lien Obligations
outstanding on such date, the date upon which such Second Lien Obligations are
paid in full and (ii) with respect to the First Lien Agent, the First Lien
Claimholders and the First Lien Obligations, the date of Discharge of First Lien
Obligations.

     SECTION 9.5. Amendments; Waivers. No amendment, modification or waiver of
any of the provisions of this Agreement by the Trustee or the First Lien Agent
shall be deemed to be made unless the same shall be in writing signed on behalf
of each such party hereto or its authorized agent and each waiver, if any, shall
be a waiver only with respect to the specific instance involved and shall in no
way impair the rights of the parties making such waiver or the obligations of
the other parties to such party in any other respect or at any other time.

     SECTION 9.6. Information Concerning Financial Condition of Obligors. The
First Lien Claimholders, on the one hand, and the Second Lien Claimholders, on
the other hand, shall each be responsible for keeping themselves informed of (i)
the financial condition of Royalty Sub and all of the other Obligors and (ii)
all other circumstances bearing upon the risk of nonpayment of the First Lien
Obligations or the Second Lien Obligations. The First Lien Agent and the First
Lien Claimholders shall have no duty to advise the Trustee or any Second Lien
Claimholder of information known to it or them regarding such condition or any
such circumstances or otherwise. In the event the First Lien Agent or any of the
First Lien Claimholders, in its or their sole discretion, undertakes at any time
or from time to time to provide any such information to the Trustee or any
Second Lien Claimholder, it or they shall be under no obligation (w) to make,
and the First Lien Agent and the First Lien Claimholders shall not make, any
express or implied representation or warranty, including with respect to the
accuracy, completeness, truthfulness or validity of any such information so
provided, (x) to provide any additional information or to provide any such
information on any subsequent occasion, (y) to undertake any investigation or
(z) to disclose any information which, pursuant to accepted or reasonable
commercial finance practices, such party wishes to maintain confidential or is
otherwise required to maintain confidential. The Trustee and the Second Lien
Claimholders shall have no duty to advise the First Lien Agent or any First Lien
Claimholder of information known to it or them regarding such condition or any
such circumstances or otherwise. In the event the Trustee or any of the Second
Lien Claimholders, in its or their sole discretion, undertakes at any time or
from time to time to provide any such information to the First Lien Agent or any
First Lien Claimholder, it or they shall be under no obligation (A) to make, and
the Trustee and the Second Lien Claimholders shall not make, any express or
implied representation or warranty, including with respect to the accuracy,
completeness, truthfulness or validity of any such information so provided, (B)
to provide any additional information or to provide any such information on any
subsequent occasion, (C) to undertake any investigation or (D) to disclose any
information which, pursuant

                                      -33-
<PAGE>
to accepted or reasonable commercial finance practices, such party wishes to
maintain confidential or is otherwise required to maintain confidential.

     SECTION 9.7. Subrogation. Subject to the Discharge of First Lien
Obligations, with respect to the value of any payments or distributions in cash,
property or other assets that the Second Lien Claimholders or Trustee pay over
to the Collection Agent for the benefit of the First Lien Agent or First Lien
Claimholders under the terms of this Agreement, the Second Lien Claimholders and
the Trustee shall be subrogated to the rights of the First Lien Agent and First
Lien Claimholders; provided, that the Trustee, on behalf of itself and the
Second Lien Claimholders, hereby agrees not to assert or enforce all such rights
of subrogation it may acquire as a result of any payment hereunder until the
Discharge of First Lien Obligations has occurred. With respect to the value of
any payments or distributions in cash, property or other assets received by the
Trustee or the Second Lien Claimholders and paid over to the Collection Agent
for the benefit of the First Lien Agent or the First Lien Claimholders pursuant
to, and applied in accordance with, this Agreement, the Second Lien Obligations
shall not be relieved or reduced by any such paid-over payment or distribution.

     SECTION 9.8. SUBMISSION TO JURISDICTION; WAIVERS.

          (a) THE PARTIES HERETO IRREVOCABLY AND UNCONDITIONALLY SUBMIT TO THE
     NONEXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF NEW YORK SITTING IN
     NEW YORK CITY AND OF THE UNITED STATES DISTRICT COURT SITTING IN NEW YORK
     CITY, AND ANY APPELLATE COURT FROM ANY THEREOF, IN ANY ACTION OR PROCEEDING
     ARISING OUT OF, UNDER, OR IN CONNECTION WITH, THIS AGREEMENT, OR ANY COURSE
     OF CONDUCT, COURSE OF DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN) OR
     ACTIONS OF SUCH PARTY IN CONNECTION HEREWITH, OR FOR RECOGNITION OR
     ENFORCEMENT OF ANY JUDGMENT, AND EACH OF THE PARTIES HERETO IRREVOCABLY AND
     UNCONDITIONALLY AGREES THAT ALL CLAIMS IN RESPECT OF ANY SUCH ACTION OR
     PROCEEDING MAY BE HEARD AND DETERMINED IN SUCH NEW YORK STATE COURT OR, TO
     THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, IN SUCH FEDERAL COURT. EACH
     OF THE PARTIES HERETO AGREES THAT A FINAL JUDGMENT IN ANY SUCH ACTION OR
     PROCEEDING SHALL BE CONCLUSIVE AND MAY BE ENFORCED IN OTHER JURISDICTIONS
     BY SUIT ON THE JUDGMENT OR IN ANY OTHER MANNER PROVIDED BY LAW.

          (b) THE PARTIES HERETO IRREVOCABLY AND UNCONDITIONALLY WAIVE, TO THE
     FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY OBJECTION WHICH EACH MAY
     NOW OR HEREAFTER HAVE TO THE LAYING OF VENUE OF ANY ACTION OR PROCEEDING
     ARISING OUT OF OR RELATING TO THIS AGREEMENT IN ANY COURT REFERRED TO IN
     CLAUSE (a) of SECTION 9.8. EACH OF THE PARTIES HERETO HEREBY IRREVOCABLY
     WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, THE DEFENSE OF
     AN INCONVENIENT FORUM TO THE MAINTENANCE OF SUCH ACTION OR PROCEEDING IN
     ANY SUCH COURT, AND TO THE EXTENT THAT

                                      -34-
<PAGE>
     SUCH PARTY HAS OR HEREAFTER MAY ACQUIRE ANY IMMUNITY FROM JURISDICTION OF
     ANY COURT OR FROM ANY LEGAL PROCESS (WHETHER THROUGH SERVICE OR NOTICE,
     ATTACHMENT PRIOR TO JUDGMENT, ATTACHMENT IN AID OF EXECUTION OR OTHERWISE)
     WITH RESPECT TO ITSELF OR ITS PROPERTY, SUCH PARTY HEREBY IRREVOCABLY
     WAIVES TO THE FULLEST EXTENT PERMITTED BY LAW SUCH IMMUNITY IN RESPECT OF
     ITS OBLIGATIONS UNDER THIS AGREEMENT.

          (c) EACH PARTY HERETO HEREBY KNOWINGLY, VOLUNTARILY, INTENTIONALLY AND
     IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY
     RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LEGAL PROCEEDING DIRECTLY OR
     INDIRECTLY ARISING OUT OF OR RELATING TO THIS AGREEMENT AND THE
     TRANSACTIONS CONTEMPLATED HEREBY, AND ANY COURSE OF CONDUCT, COURSE OF
     DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN) OR ACTIONS OF SUCH PARTY IN
     CONNECTION HEREWITH (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY).
     EACH PARTY HERETO (A) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY
     OF ANY OTHER PERSON HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH
     OTHER PERSON WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE
     FOREGOING WAIVER, (B) ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO
     HAVE BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE
     MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION AND (C) ACKNOWLEDGES AND
     AGREES THAT IT HAS RECEIVED FULL AND SUFFICIENT CONSIDERATION FOR THIS
     SECTION AND THAT THIS SECTION IS A MATERIAL INDUCEMENT FOR IT ENTERING INTO
     THIS AGREEMENT.

     SECTION 9.9. Notices. All notices to the Second Lien Claimholders and the
First Lien Claimholders permitted or required under this Agreement may be sent
to the Trustee and the First Lien Agent, respectively. All notices to the
Collection Agent shall be sent to it at the address set forth beneath its
signature hereto, or such other address as the Collection Agent indicates in
writing to the other parties hereto. Unless otherwise specifically provided
herein, any notice or other communication herein required or permitted to be
given shall be in writing and may be personally served, electronically mailed or
sent by courier service or U.S. mail and shall be deemed to have been given when
delivered in person or by courier service, upon receipt of electronic mail or
four Business Days after deposit in the U.S. mail (registered or certified, with
postage prepaid and properly addressed). For the purposes hereof, the addresses
of the parties hereto shall be as set forth below each party's name on the
signature pages hereto, or, as to each party, at such other address as may be
designated by such party from time to time in a written notice to all of the
other parties.

     SECTION 9.10. Further Assurances. Each of the Collection Agent, the First
Lien Agent, on behalf of itself and the First Lien Claimholders, and the
Trustee, on behalf of itself and the Second Lien Claimholders, agrees that it
shall take such further action and shall execute and deliver such additional
documents and instruments (in recordable form, if requested) as the

                                      -35-
<PAGE>
Collection Agent, the First Lien Agent or the Trustee may reasonably request to
effectuate the terms of and the lien priorities contemplated by this Agreement.

     SECTION 9.11. APPLICABLE LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND
SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW
YORK.

     SECTION 9.12. Binding on Successors and Assigns. This Agreement shall be
binding upon the Secured Creditors and their respective successors and assigns.

     SECTION 9.13. Specific Performance. Each of the First Lien Agent and the
Trustee may demand specific performance of this Agreement. The First Lien Agent,
on behalf of itself and the First Lien Claimholders, and the Trustee, on behalf
of itself and the Second Lien Claimholders, hereby irrevocably waives any
defense based on the adequacy of a remedy at law and any other defense which
might be asserted to bar the remedy of specific performance in any action which
may be brought by the First Lien Agent or the Trustee, as the case may be.

     SECTION 9.14. Headings. Section headings in this Agreement are included
herein for convenience of reference only and shall not constitute a part of this
Agreement for any other purpose or be given any substantive effect.

     SECTION 9.15. Counterparts. This Agreement may be executed in counterparts
(and by different parties hereto in different counterparts), each of which shall
constitute an original, but all of which when taken together shall constitute a
single contract. Delivery of an executed counterpart of a signature page of this
Agreement or any document or instrument delivered in connection herewith by
telecopy shall be effective as delivery of a manually executed counterpart of
this Agreement or such other document or instrument, as applicable.

     SECTION 9.16. Authorization. By its signature, each Person executing this
Agreement on behalf of a party hereto represents and warrants to the other
parties hereto that it is duly authorized to execute this Agreement.

     SECTION 9.17. No Third Party Beneficiaries; Effect of Agreement. This
Agreement and the rights and benefits hereof shall inure to the benefit of each
of the parties hereto and its respective successors and assigns and shall inure
to the benefit of each of the First Lien Claimholders and the Second Lien
Claimholders. No other Person shall have or be entitled to assert rights or
benefits hereunder. Nothing in this Agreement shall impair, as among the
Obligors and the First Lien Agent and the First Lien Claimholders, on the one
hand, and the Obligors and the Trustee and the Second Lien Claimholders, on the
other hand, the obligations of the Obligors to pay principal, interest, fees and
other amounts as provided in the First Lien Documents and the Second Lien
Documents, respectively.

     SECTION 9.18. Immunity; Judgment Currency. (a) To the extent any Obligor
may in any jurisdiction claim for itself or its assets immunity (to the extent
such immunity may now or hereafter exist, whether on the grounds of sovereign
immunity or otherwise) from suit, execution, attachment (whether in aid of
execution, before judgment or otherwise) or other legal process (whether through
service or notice or otherwise), and to the extent that in any such jurisdiction
there may be attributed to itself or its assets such immunity (whether or not
claimed),

                                      -36-
<PAGE>
each Obligor irrevocably agrees with respect to any matter arising under this
Agreement and each other First Lien Document and Second Lien Document for the
benefit of the Secured Creditors not to claim, and irrevocably waives, such
immunity to the full extent permitted by the laws of such jurisdiction.

          (b) If, for the purpose of obtaining a judgment or order in any court,
     it is necessary to convert a sum due hereunder to any Secured Creditor from
     Dollars into another currency, each Obligor hereby agrees, and each Secured
     Creditor agrees, to the fullest extent that they may effectively do so,
     that the rate of exchange used shall be that at which, in accordance with
     normal banking procedures, such Secured Creditor could purchase Dollars
     with such other currency in the Borough of Manhattan, The City of New York
     on the Business Day immediately preceding the day on which final judgment
     is given.

          (c) The obligation of any Obligor in respect of any sum payable by it
     to a Secured Creditor shall, notwithstanding any judgment or order in a
     currency other than Dollars (the "Judgment Currency"), be discharged only
     to the extent that, on the Business Day immediately following receipt by
     such Secured Creditor of such security of any sum adjudged to be so due in
     the Judgment Currency, such Secured Creditor may in accordance with normal
     banking procedures purchase Dollars with the Judgment Currency. If the
     amount of Dollars so purchased is less than the sum originally due to such
     Secured Creditor in the Judgment Currency (determined in the manner set
     forth in clause (b) above), each Obligor agrees, as a separate obligation
     and notwithstanding any such judgment, to indemnify such Secured Creditor
     against such loss, and, if the amount of Dollars so purchased exceeds the
     sum originally due to such Secured Creditor, such Secured Creditor agrees
     to remit to such Obligor such excess, provided that such Secured Creditor
     shall have no obligation to remit any such excess as long as such Obligor
     shall have failed to pay to such Secured Creditor any obligations due and
     payable to such Secured Creditor under any Loan Document, in which case
     such excess may be applied to such obligations of such Obligor in
     accordance with the terms thereof. The foregoing indemnity shall constitute
     a separate and independent obligation of each Obligor and shall continue in
     full force and effect notwithstanding any such judgment or order as
     aforesaid.

     SECTION 9.19. Limited Recourse. Each of the parties hereto accepts that the
enforceability against Royalty Sub of the obligations of Royalty Sub hereunder
shall be limited to the assets of Royalty Sub, whether tangible or intangible,
real or personal (including the Collateral) and the proceeds thereof. Once all
such assets have been realized upon and such assets (and proceeds thereof) have
been applied in accordance with Section 3, any outstanding obligations of
Royalty Sub shall be extinguished. Each of the parties hereto further agrees
that it shall take no action against any employee, director, principal, agent,
officer or administrator of Royalty Sub, the First Lien Agent, the Trustee or
the Collection Agent in relation to this Agreement; provided, that nothing
herein shall limit Royalty Sub (or its permitted successors or assigns,
including any party hereto that becomes such a successor or assign) from
pursuing claims, if any, against any such Person; provided further that the
foregoing shall not in any way limit, impair or otherwise affect any rights of
the First Lien Claimholders or the Second Lien Claimholders to proceed against
any Person (a) for intentional and willful fraud or intentional

                                      -37-
<PAGE>
and willful misrepresentations on the part of or by such Person and (b) for the
receipt of any distributions or payments to which Royalty Sub or any successor
in interest is entitled, other than distributions expressly permitted pursuant
to this Agreement. The provisions of this Section 9.19 shall survive termination
of this Agreement.

                                      -38-
<PAGE>
     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the date first written above.

                                        FIRST LIEN AGENT

                                        MORGAN STANLEY SENIOR FUNDING, INC.,
                                        in its capacity as First Lien Agent

                                        By: /s/ Eugene F. Martin
                                            ------------------------------------
                                        Name: Eugene F. Martin
                                        Title: Vice President

                                        Address: One Pierrepont Plaza, 7th Floor
                                        300 Cadman Plaza West
                                        Brooklyn, NY 11201

                                        Facsimile: 718-754-7250
                                        Attention: Edward Henley

                                        TRUSTEE

                                        U.S. BANK NATIONAL ASSOCIATION,
                                        in its capacity as Trustee

                                        By: /s/ Alison D. B. Nadeau
                                            ------------------------------------
                                        Name: Alison D. B. Nadeau
                                        Title: Vice President

                                        Address: U.S. Bank National Association
                                        One Federal Street, 3rd Floor
                                        Boston, MA 02110

                                        Facsimile: 617-6036683
                                        Attention: Corporate Trust Services
                                                   (Duloxetine Royalty Sub)

                                        COLLECTION AGENT

                                        U.S. BANK NATIONAL ASSOCIATION,
                                        in its capacity as Collection Agent

                                        By: /s/ Alison D. B. Nadeau
                                            ------------------------------------
<PAGE>
                                        Name: Alison D. B. Nadeau
                                        Title: Vice President

                                        Address: U.S. Bank National Association
                                        One Federal Street, 3rd Floor
                                        Boston, MA 02110

                                        Facsimile: 617-6036683
                                        Attention: Corporate Trust Services
                                                   (Duloxetine Royalty Sub)

                                        DULOXETINE ROYALTY SUB

                                        By: /s/ Santiago M. Estrada
                                            ------------------------------------
                                        Name: Santiago M. Estrada
                                        Title: Vice President and Secretary

                                        Address: c/o Walkers SPV Limited
                                        P.O. Box 908GT, Walker House
                                        Mary Street, George Town, Grand Cayman
                                        Cayman Islands

                                        Facsimile No.: 345-945-4757
                                        Attention: The Director

                                        DULOXETINE HOLDCO ROYALTY SUB

                                        By: /s/ John L. Bradley, Jr.
                                            ------------------------------------
                                        Name: John L. Bradley, Jr.
                                        Title: Vice President

                                        Address: c/o Walkers SPV Limited
                                        P.O. Box 908GT, Walker House
                                        Mary Street, George Town, Grand Cayman
                                        Cayman Islands

                                        Facsimile No.: 345-945-4757
                                        Attention: The Director
<PAGE>
                                     ANNEX A
                                  DEFINED TERMS

     "Accounts" means the Collection Account, the Holding Account, any
Repayment/Redemption Account, any Escrow Account, any Capital Account and any
other account established pursuant to this Agreement.

     "Additional Amounts" has the meaning set forth in Section 5.3 of the
Indenture.

     "Additional Interest" means, with respect to the Notes, interest accrued on
the amount of any interest and Premium, if any, in respect of such Notes that is
not paid when due at the Stated Rate of Interest of such Notes for each Interest
Accrual Period until any such unpaid interest or Premium is paid in full,
compounded quarterly on each Payment Date, to the fullest extent permitted by
Applicable Law.

     "Administrative Agent" means Morgan Stanley Senior Funding, Inc., or any
successor appointed pursuant to the terms of the Credit Agreement.

     "Affiliate" means, with respect to any Person, any other Person that,
directly or indirectly, controls, is controlled by or is under common control
with such Person or is a director, officer or manager of such Person. For
purposes of this definition, "control" of a Person means the possession,
directly or indirectly, of the power (a) to vote 10% or more of the Capital
Securities (on a fully diluted basis) of such Person having ordinary voting
power for the election of directors, managing members or general partners (as
applicable) or (b) to direct or cause the direction of the management and
policies of such Person, whether through the ownership of Voting Securities, by
contract or otherwise.

     "Agent Members" has the meaning set forth in Section 2.10(a) of the
Indenture.

     "Agents" means each of the First Lien Agent, the Trustee and the Collection
Agent.

     "Agreement" is defined in the preamble.

     "Applicable Law" means, with respect to any Person, all laws, rules,
regulations and orders of Governmental Authorities applicable to such Person or
any of its properties or assets.

     "Applicable Margin" has the meaning set forth in Annex A of the Credit
Agreement.

     "Applicable Treasury Rate" for any Redemption Date means the interest rate
(expressed as a semiannual decimal and, in the case of United States Treasury
bills, converted to a bond equivalent yield) determined on the fourth Business
Day prior to such Redemption Date to be the per annum rate equal to the
semiannual yield to maturity for United States Treasury securities maturing on
the Average Life Date of the Original Class A Notes as of such Redemption Date
and trading in the public securities markets either (a) as determined by
interpolation between the most recent weekly average yield to maturity for two
series of United States Treasury securities trading in the public securities
markets, (i) one maturing as close as possible to, but earlier than, the Average
Life Date of the Original Class A Notes and (ii) the other maturing as close as
possible to, but later than, the Average Life Date of the Original Class A
Notes, in each case as

                                       A-1
<PAGE>
published in the most recent H.15 (519) or (b) if a weekly average yield to
maturity for United States Treasury securities maturing on the Average Life Date
of the Original Class A Notes is reported in the most recent H.15 (519), such
weekly average yield to maturity as published in such H.15 (519).

     "Available Collections Amount" means, as of any Payment Date, the sum of
(a) the amount on deposit in the Collection Account as of the Calculation Date
immediately preceding such Payment Date, (b) the amount of any net investment
income on amounts in the Accounts as of such Calculation Date, (c) the amount of
any Hedge Receipts due on such Payment Date and (d) with respect to periods
following the Discharge of First Lien Obligations, the amount in the Holding
Account as of such Calculation Date to be transferred to the Collection Account
on such Payment Date if (i) an Event of Default under the Indenture has occurred
and is continuing, (ii) the Interest Coverage Ratio for such Payment Date is not
equal to or greater than the specified ratio for such Payment Date as set forth
in Section 3.11 (as determined pursuant to Section 3.5), (iii) on or after June
15, 2008, the Patent Extension Event has not occurred or (iv)(x) the Trustee has
received written notice from Noteholders of at least 25% of the Outstanding
Principal Balance of the Class A Notes that a Material Adverse Development has
occurred and (y) the Trustee has not received further written notice from
Noteholders of a majority of the Outstanding Principal Balance of the Class A
Notes that such Material Adverse Development has ended or is no longer
applicable.

     "Average Life Date" of the Original Class A Notes means the date that
follows the applicable Redemption Date by a period equal to the Remaining
Weighted Average Life of the Original Class A Notes.

     "Bankruptcy Code" means Title 11 of the United States Code entitled
"Bankruptcy", as now and hereafter in effect, or any successor statute

     "Bankruptcy Law" means the Bankruptcy Code and any similar federal, state
or foreign law for the relief of debtors.

     "Beneficial Holder" means any Person that holds a Beneficial Interest in
any Global Note through an Agent Member.

     "Beneficial Interest" means any beneficial interest in any Global Note,
whether held directly by an Agent Member or held indirectly through an Agent
Member's beneficial interest in such Global Note.

     "Bill of Sale" means, collectively, the Pledgor Bill of Sale and the
Royalty Sub Bill of Sale.

     "Board Resolution" means a copy of a resolution certified by an officer of
Royalty Sub as having been duly adopted by the board of directors of Royalty Sub
and being in full force and effect on the date of such certification.

     "Business Day" means (a) any day that is not a Saturday, Sunday or legal
holiday on which commercial banks are authorized or required to be closed in New
York, New York and (b) for purposes of calculating amounts at the London
interbank offered rate and related calculations

                                       A-2
<PAGE>
relative to the making, continuing, prepaying or repaying of Indebtedness in
respect thereof, any day that is a Business Day described in clause (a) that is
also a day on which dealings in U.S. dollars are carried on in the London
interbank market.

     "Calculation Agent" means U.S. Bank National Association and any successor
appointed pursuant to Section 6.11 of the Indenture.

     "Calculation Date" means, for any Payment Date, the fifth Business Day
immediately preceding such Payment Date.

     "Calculation Report" is defined in clause (c) of Section 3.5.

     "Capital Account" is defined in clause (a) of Section 3.1.

     "Capital Securities" means, with respect to any Person, all shares,
interests, participations or other equivalents (however designated, whether
voting or non-voting) of such Person's capital, whether now outstanding or
issued after the Closing Date, including common shares, ordinary shares,
preferred shares, membership interests or share capital in a limited liability
company or other Person, limited or general partnership interests in a
partnership, beneficial interests in trusts or any other equivalent of such
ownership interest or any options, warrants and other rights to acquire such
shares or interests, including rights to allocations and distributions,
dividends, redemption payments and liquidation payments.

     "Cash Purchase Price" means U.S.$239,890,387.91.

     "Class A Notes" means the Original Class A Notes and any Refinancing Notes
issued to refinance the foregoing.

     "Class A Principal Payment Schedule" means the schedule of Scheduled
Remaining Notes Balances as of a particular Payment Date set forth in Schedule 1
to the Indenture, as it may be adjusted pursuant to Section 2.17 of the
Indenture.

     "Class B Notes" means the Class B Notes, if any, issued in such form as
shall be authorized by a Board Resolution and any indenture supplemental to the
Indenture in respect thereof pursuant to Section 2.16 of the Indenture and any
Refinancing Notes issued to refinance the foregoing.

     "Closing Date" means the date of the borrowing of the Loans and the
issuance of the Second Lien Notes.

     "Code" means the Internal Revenue Code of 1986 and the regulations
thereunder, in each case as amended, reformed or otherwise modified from time to
time.

     "Collateral" means all of the assets and property of any Obligor, whether
real, personal or mixed, including all proceeds and products of any of the
foregoing, constituting First Lien Collateral or Second Lien Collateral.

     "Collection Account" is defined in clause (a) of Section 3.1.

                                       A-3
<PAGE>
     "Collection Agent" means, initially, U.S. Bank National Association, and
thereafter, each successor Collection Agent as described in Section 9.1.

     "Collections" means, without duplication, (a) Royalty Sub Payments, (b) any
Hedge Receipts, (c) any investment income on amounts on deposit in the Accounts
and (d) any other amounts received by Royalty Sub (other than the proceeds of
any Loans or Notes and capital contributions from the Pledgor or Quintiles).

     "Confidentiality Agreement" means, with respect to any Lender or any of its
Affiliates with respect to the Loans or with respect to Noteholders or
Beneficial Holders at the Closing Date with respect to the Original Class A
Notes (or, with respect to Class B Notes or any Refinancing Notes, the date of
issuance of such Class B Notes or Refinancing Notes), a confidentiality
agreement with Royalty Sub provided to the Administrative Agent or the
Registrar, as the case may be, on or prior to the Closing Date (or such date of
issuance), and otherwise means a resale confidentiality agreement with Royalty
Sub substantially in the form of Exhibit H to the Credit Agreement or Exhibit B
to the Indenture, as the case may be.

     "Co-Promotion Agreement" means that certain Duloxetine-Depression U.S.
Co-Promotion Agreement, effective as of July 18, 2002, between Quintiles and
Lilly, as amended by the First Amendment thereto dated as of December 1, 2003
and the Second Amendment thereto dated as of August 18, 2005, and as amended,
restated, supplemented or otherwise modified from time to time in accordance
with the terms of the Credit Agreement and the Indenture, if applicable.

     "Corporate Trust Office" means the office of the Trustee in the city at
which at any particular time the Trustee's duties under the Transaction
Documents shall be principally administered and, on the Closing Date, shall be
One Federal Street, 3rd Floor, Boston, Massachusetts 02110.

     "Credit Agreement" means that certain credit agreement, dated as of the
Closing Date, among Royalty Sub, the Pledgor, Quintiles (with respect to only
certain sections set forth therein), the Lenders and the Administrative Agent,
including the Annex, Schedule and Exhibits attached thereto, as amended,
restated, supplemented or otherwise modified from time to time.

     "Default" means a condition, event or act that, with the giving of notice
or the lapse of time or both, would constitute an Event of Default; provided,
that a failure to pay interest on the Loans or the Class A Notes when such
amount becomes due on any Payment Date other than the Final Maturity Date or any
Redemption Date does not constitute a Default; provided, further, that a failure
to pay any such interest not so paid on any such Payment Date in full with
Additional Interest thereon by the next succeeding Payment Date shall be an
immediate Event of Default.

     "DIP Financing" has the meaning set forth in clause (a) of Section 7.1.

     "DIP Lender" has the meaning set forth in clause (a) of Section 7.1.

     "Direction" has the meaning set forth in Section 1.4(c) of the Indenture.

                                       A-4
<PAGE>
     "Discharge of First Lien Obligations" means (i) payment in full in cash of
the principal of and interest (including interest accruing on or after the
commencement of any Insolvency or Liquidation Proceeding, whether or not such
interest would be allowed in such Insolvency or Liquidation Proceeding) and
premium, if any, on all funded Indebtedness outstanding under the First Lien
Documents, (ii) payment in full in cash of all other First Lien Obligations that
are due and payable or otherwise accrued and owing at or prior to the time such
principal, interest and premium, if any, are paid and (iii) termination of all
commitments of the First Lien Claimholders to extend credit under the First Lien
Documents, other than, in the case of each of the preceding clauses (i) through
(iii), any such payment or termination in connection with a Refinancing.

     "Distribution Report" has the meaning set forth in Section 3.14.

     "Dollar" or the sign "$" means lawful money of the United States.

     "Eligible Account" means a trust account maintained on the books and
records of an Eligible Institution in the name of the Collection Agent.

     "Eligible Institution" means any bank organized under the laws of the U.S.
or any state thereof or the District of Columbia (or any domestic branch of a
foreign bank), which at all times has either (a) a long-term unsecured debt
rating of at least A2 by Moody's and A by S&P and Fitch or (b) a certificate of
deposit rating of at least P-1 by Moody's, A-1 by S&P and F1 by Fitch.

     "Eligible Investments" means, in each case, book-entry securities,
negotiable instruments or securities represented by instruments in bearer or
registered form that evidence:

          (a) direct obligations of, and obligations fully Guaranteed as to
     timely payment of principal and interest by, the U.S. or any agency or
     instrumentality thereof the obligations of which are backed by the full
     faith and credit of the U.S. (having original maturities of no more than
     365 days or such lesser time as is required for the distribution of funds);

          (b) demand deposits, time deposits or certificates of deposit of the
     Operating Bank or of depositary institutions or trust companies organized
     under the laws of the U.S. or any state thereof or the District of Columbia
     (or any domestic branch of a foreign bank) (i) having original maturities
     of no more than 365 days or such lesser time as is required for the
     distribution of funds; provided, that, at the time of investment or
     contractual commitment to invest therein, the short-term debt rating of
     such depositary institution or trust company shall be at least P-1 by
     Moody's, A-1 by S&P and F1 by Fitch or (ii) having maturities of more than
     365 days and, at the time of the investment or contractual commitment to
     invest therein, a rating of at least A2 by Moody's and A by S&P and Fitch;

          (c) corporate or municipal debt obligations (i) having remaining
     maturities of no more than 365 days or such lesser time as is required for
     the distribution of funds and having, at the time of the investment or
     contractual commitment to invest therein, a rating of at least P-1 or A2 by
     Moody's, A-1 or A by S&P and F1 or A by Fitch or (ii) having maturities of
     more than 365 days and, at the time of the investment or contractual

                                       A-5
<PAGE>
     commitment to invest therein, a rating of at least A2 by Moody's and A by
     S&P and Fitch;

          (d) investments in money market funds (including funds in respect of
     which the Administrative Agent, the Trustee or any of their respective
     Affiliates is investment manager or otherwise) having a rating of at least
     A2 by Moody's, Am by S&P and A by Fitch; or

          (e) notes or bankers' acceptances (having original maturities of no
     more than 365 days or such lesser time as is required for the distribution
     of funds) issued by any depositary institution or trust company referred to
     in clause (b) above;

provided, however, that no investment shall be made in any obligations of any
depositary institution or trust company that is identified in a written notice
to the Administrative Agent or, after the Discharge of First Lien Obligations,
the Trustee from Royalty Sub or Servicer as having a contractual right to set
off and apply any deposits held, and other indebtedness owing, by Royalty Sub to
or for the credit or the account of such depositary institution or trust
company, unless such contractual right by its terms expressly excludes all
Eligible Investments.

     "Equity Interests" means, with respect to any Person, all shares,
interests, participations or other equivalents (however designated, whether
voting or non-voting) of such Person's capital, whether now outstanding or
issued after the Closing Date, including common shares, ordinary shares,
preferred shares, membership interests or share capital in a limited liability
company or other Person, limited or general partnership interests in a
partnership, beneficial interests in trusts or any other equivalent of such
ownership interest or any options, warrants and other rights to acquire such
shares or interests, including rights to allocations and distributions,
dividends, redemption payments and liquidation payments.

     "ERISA" means the U.S. Employee Retirement Income Security Act of 1974, as
amended.

     "ERISA Affiliate" means any trade or business that is treated as a single
employer with Royalty Sub, the Pledgor or Quintiles under Section 414 of the
Code.

     "Escrow Account" is defined in clause (a) of Section 3.1.

     "Event of Default" means either (i) an Event of Default under, and as
defined in, the First Lien Credit Agreement or (ii) an Event of Default under,
and as defined in, the Indenture.

     "Exchange Act" means the U.S. Securities Exchange Act of 1934, as amended.

     "Exigent Circumstance" means (i) the exercise by any Person (other than a
Secured Creditor) of enforcement rights or remedies with respect to any
Collateral or (ii) any other event or circumstance that materially and
imminently threatens the ability of the First Lien Claimholders to realize upon
all or a material part of the Collateral, including fraudulent removal,
concealment or abscondment thereof or destruction (other than to the extent
covered by insurance) or material waste thereof.

                                       A-6
<PAGE>
     "Expenses" means any reasonable out-of-pocket fees, costs or expenses of
Royalty Sub, including the fees, expenses and indemnities of the Service
Providers, the fees and out-of-pocket expenses of counsel to the Administrative
Agent, the Trustee and Royalty Sub incurred after the Closing Date in connection
with the transactions contemplated by the Transaction Documents, the fees and
expenses of any nationally recognized independent public accounting firm engaged
as auditors of Royalty Sub and any payments under indemnity obligations of
Royalty Sub to any Person other than Quintiles; provided, however, that, except
as expressly provided in this Agreement, the Credit Agreement or the Indenture,
Expenses shall not include any Transaction Expenses, any amounts payable on the
Loans or the Notes, any Hedge Payment, the fees, costs or expenses relating to
the Class B Notes or any other amounts ranking pari passu with or junior to
interest payable on the Loans or the Notes in the priority of payments set forth
in this Agreement.

     "Filing Collateral" is defined in clause (c) of Section 5.5.

     "Final Maturity Date" means, with respect to (a) the Original Class A
Notes, October 15, 2013, (b) with respect to any Class B Notes or Refinancing
Notes, the date specified in the indenture supplemental to the Indenture
providing for their issuance; provided, that the Final Maturity Date with
respect to any Class B Notes or Refinancing Notes shall be no earlier than
October 15, 2013, and (c) the Loans, the same meaning as "Stated Maturity Date"
as defined in the Credit Agreement.

     "First Lien Agent" is defined in the preamble, and includes any agent
acting on its behalf.

     "First Lien Claimholders" means, at any relevant time, the holders of First
Lien Obligations at such time.

     "First Lien Collateral" means all of the assets and property of any
Obligor, whether real, personal or mixed, with respect to which a Lien is
granted by such Obligor as security for any First Lien Obligations.

     "First Lien Collateral Documents" means, collectively, the Loan Security
Agreement, the First Lien Pledge and Security Agreement and any other agreement,
document or instrument pursuant to which a Lien is granted securing any First
Lien Obligations or under which rights or remedies with respect to such Liens
are governed.

     "First Lien Credit Agreement" has the meaning set forth in the recitals
hereto.

     "First Lien Documents" means the First Lien Credit Agreement and the First
Lien Collateral Documents, including any documents or instruments executed or
delivered in connection with a Refinancing.

     "First Lien Obligations" means all Obligations outstanding under the First
Lien Credit Agreement and the other First Lien Documents; provided, that in no
event shall the aggregate outstanding principal amount of the Loans at any time
exceed the Maximum First Lien Principal Amount. "First Lien Obligations" shall
include all interest accrued or accruing (or which would, absent commencement of
an Insolvency or Liquidation Proceeding, accrue) after commencement of an
Insolvency or Liquidation Proceeding in accordance with the rate specified in
the relevant First Lien Document whether or not the claim for such interest is
allowed as a claim in such

                                      A-7
<PAGE>
Insolvency or Liquidation Proceeding. To the extent any payment with respect to
the First Lien Obligations (whether by or on behalf of any Obligor, as proceeds
of security, enforcement of any right of setoff or otherwise) is declared to be
fraudulent or preferential in any respect, set aside or required to be paid or
turned over to a debtor in possession, trustee, receiver or similar Person, then
the obligation or part thereof originally intended to be satisfied shall be
deemed to be reinstated and outstanding as if such payment had not occurred.

     "First Lien Pledge and Security Agreement" means that certain first lien
pledge and security agreement dated as of the Closing Date made by the Pledgor
to the Administrative Agent, including the Exhibits attached thereto, as
amended, restated, supplemented or otherwise modified from time to time.

     "Fitch" means Fitch, Inc. and any successor thereto or, if such corporation
or its successor shall for any reason no longer perform the functions of a
securities rating agency, "Fitch" shall be deemed to refer to any other
nationally recognized statistical rating organization (within the meaning
ascribed thereto by the Exchange Act) designated by Royalty Sub.

     "Fixed Rate Notes" means the Original Class A Notes and any Class B Notes
or Refinancing Notes issued with a fixed rate of interest.

     "Floating Rate Notes" means any Class B Notes or Refinancing Notes issued
with a floating or variable rate of interest.

     "GAAP" means generally accepted accounting principles in effect in the U.S.
from time to time.

     "Global Notes" means any Permanent Global Notes and Regulation S Global
Notes.

     "Governmental Authority" means the government of the United States, any
other nation or any political subdivision thereof, whether state or local, and
any agency, authority, instrumentality, regulatory body, court, central bank or
other Person exercising executive, legislative, judicial, taxing, regulatory or
administrative powers or functions of or pertaining to government.

     "Guarantee" means any obligation, contingent or otherwise, of any Person
directly or indirectly guaranteeing any Indebtedness or other obligation of any
other Person and, without limiting the generality of the foregoing, any
obligation, direct or indirect, contingent or otherwise, of such Person (a) to
purchase or pay (or advance or supply funds for the purchase or payment of) such
Indebtedness or other obligation of such other Person or (b) entered into for
purposes of assuring in any other manner the obligee of such Indebtedness or
other obligation of the payment thereof or to protect such obligee against loss
in respect thereof (in whole or in part); provided, that the term "Guarantee"
shall not include endorsements for collection or deposit in the ordinary course
of business. The term "Guarantee" when used as a verb has a corresponding
meaning.

     "Hedge Agreement" means the interest rate cap agreement between Royalty Sub
and the Hedge Provider, having an effective date of the Closing Date.

                                      A-8
<PAGE>
     "Hedge Payment" means a net payment to the Hedge Provider by Royalty Sub on
the Closing Date.

     "Hedge Provider" means Morgan Stanley Capital Services Inc., the
counterparty of Royalty Sub under the Hedge Agreement.

     "Hedge Receipt" means a net payment to be made by the Hedge Provider into
the Collection Account under the Hedge Agreement and includes any termination
payment received from the Hedge Provider.

     "Holding Account" is defined in clause (a) of Section 3.1.

     "Incur" has the meaning set forth in Section 5.1(d) of the Indenture.

     "Indebtedness" means, with respect to any Person at any date of
determination (without duplication), (a) all indebtedness of such Person for
borrowed money, (b) all obligations of such Person evidenced by bonds,
debentures, notes or other similar instruments, (c) all obligations of such
Person as an account party in respect of letters of credit or other similar
instruments (including reimbursement obligations with respect thereto), (d) all
the obligations of such Person to pay the deferred and unpaid purchase price of
property or services, which purchase price is due more than 90 days after the
date of purchasing such property or service or taking delivery and title thereto
or the completion of such services, and payment deferrals arranged primarily as
a method of raising funds to acquire such property or service, (e) all monetary
obligations of such Person and its Subsidiaries under any leasing or similar
arrangement which have been (or, in accordance with GAAP, should be) classified
as capitalized leases, (f) all Guarantees of such Person in respect of any of
the foregoing, (g) all monetary obligations of such Person with respect to any
interest rate hedge, cap, floor, swap, option or other interest rate hedge
agreement entered into after the Closing Date, (h) all Indebtedness (as defined
in clauses (a) through (g) of this definition) of other Persons secured by a
lien on any asset of such Person, whether or not such Indebtedness is assumed by
such Person, and (i) all Indebtedness (as defined in clauses (a) through (g) of
this definition) of other Persons Guaranteed by such Person.

     "Indenture" has the meaning set forth in the recitals hereto.

     "Insolvency or Liquidation Proceeding" means (i) any voluntary or
involuntary case or proceeding under the Bankruptcy Code with respect to any
Obligor, (ii) any other voluntary or involuntary insolvency, reorganization or
bankruptcy case or proceeding, or any receivership, liquidation, reorganization
or other similar case or proceeding, with respect to any Obligor or with respect
to a material portion of its respective assets, (iii) any liquidation,
dissolution, reorganization or winding up of any Obligor whether voluntary or
involuntary and whether or not involving insolvency or bankruptcy or (iv) any
assignment for the benefit of creditors or any other marshalling of assets and
liabilities of any Obligor.

     "Intercreditor Agreement" means that certain Intercreditor Agreement, dated
as of the Closing Date, among the Administrative Agent, the Trustee, the
Collection Agent, Royalty Sub and the Pledgor, including the Annexes attached
thereto, as amended, restated, supplemented or otherwise modified from time to
time.

                                      A-9
<PAGE>
     "Interest Accrual Period" means the period beginning on (and including) the
Closing Date (or, with respect to any Class B Notes or Refinancing Notes, the
date of issuance of such Class B Notes or Refinancing Notes) and ending on (but
excluding) the first Payment Date thereafter and each successive period
beginning on (and including) a Payment Date and ending on (but excluding) the
next succeeding Payment Date; provided, however, that the final Interest Accrual
Period shall end on but exclude the Final Maturity Date (or, if earlier, with
respect to any class of Notes repaid in full, the date such class of Notes is
repaid in full).

     "Interest Amount" means, with respect to any class of Notes, on any Payment
Date, the amount of accrued and unpaid interest at the Stated Rate of Interest
with respect to such class of Notes on such Payment Date (including any
Additional Interest, if any, or Additional Amounts, if any), determined in
accordance with the terms thereof (including interest accruing after the
commencement of a proceeding in bankruptcy, insolvency or similar law, whether
or not permitted as a claim under such law).

     "Interest Coverage Ratio" means, for the Notes on each Payment Date, the
ratio, as calculated by the Servicer pursuant to Section 4.1(c)(i) of the
Servicing Agreement, of (a) the Royalty Sub Payments received during the
quarterly period ending on the Calculation Date related to such Payment Date to
(b) the sum of (i) interest at the Stated Rate of Interest on the Outstanding
Principal Balance of the Notes during the Interest Accrual Period ending on such
Payment Date and (ii) the amount of Expenses payable pursuant to Section 3.7 on
such Payment Date.

     "Judgment Currency" has the meaning set forth in clause (c) of Section
9.18.

     "Lenders" means the various financial institutions and other Persons from
time to time parties to the Credit Agreement and each other Secured Party, as
applicable.

     "LIBO Rate Loan" is defined in the First Lien Credit Agreement.

     "LIBOR" means, with respect to each Interest Accrual Period, unless
otherwise specified, the London interbank offered rate for deposits in U.S.
dollars having a term of three months for a period commencing on the second
Business Day immediately following the Reference Date for such Interest Accrual
Period in amounts of not less than U.S.$1,000,000, as such rate appears on
Telerate Page 3750 at approximately 11:00 a.m. (London time) on such Reference
Date therefor; provided, that, if three-month LIBOR cannot be determined from
Telerate Page 3750, the Collection Agent or Calculation Agent, as the case may
be, shall request the principal London offices of each of four major banks in
the London interbank market selected by the Collection Agent or Calculation
Agent, as the case may be, to provide a Rate Quotation, and, if at least two
Rate Quotations are provided, three-month LIBOR will be the arithmetic mean of
the Rate Quotations obtained by the Collection Agent or Calculation Agent, as
the case may be; provided, further, that, in the event three-month LIBOR cannot
be determined from Telerate Page 3750 as described in the Credit Agreement or
the Indenture, as the case may be, and fewer than two Rate Quotations are
available, three-month LIBOR will be the arithmetic mean of the rates quoted at
approximately 11:00 a.m. New York City time on such Reference Date by three
major banks in New York City selected by the Collection Agent or Calculation
Agent, as the case may be, for loans representative of single transactions at
such time

                                      A-10
<PAGE>
in U.S. dollars to leading European banks, having a term of three months for a
period commencing on the second Business Day immediately following such
Reference Date; provided, further, that, if fewer than three such banks selected
by the Collection Agent or Calculation Agent, as the case may be, are quoting
such rates, three-month LIBOR for the applicable Interest Accrual Period will be
deemed to be the same as three-month LIBOR in effect for the immediately
preceding Interest Accrual Period.

     "Lien" means any security interest, mortgage, pledge, hypothecation,
assignment, deposit arrangement, encumbrance, lien (statutory or otherwise),
charge against or interest in property or other priority or preferential
arrangement of any kind or nature whatsoever, in each case to secure payment of
a debt or performance of an obligation; provided, that the term "Lien", when
used with respect to the Trustee or any Second Lien Claimholder, shall not
include any judgment lien or similar lien obtained by any such Person through
the exercise of remedies that would have been available to it if it had been an
unsecured, unsubordinated creditor of the Obligors.

     "Lien Enforcement Action" shall mean, in each case, upon the occurrence and
during the continuance of an Event of Default under the First Lien Credit
Agreement, (i) any action by any Secured Creditor to foreclose on the Lien of
such Person on all or a material portion of the Collateral, (ii) any action by
any Secured Creditor to take possession of, sell or otherwise realize
(judicially or non-judicially) upon all or a material portion of the Collateral
(including by setoff or notification of account debtors), and/or (iii) the
commencement by any Secured Creditor of any legal proceedings against or with
respect to all or a material portion of the Collateral to facilitate the actions
described in clauses (i) and (ii) above; provided, that "Lien Enforcement
Action" shall not include actions taken by the Collection Agent in the course of
collection of amounts to be deposited in any of the Accounts, regardless of
whether such collection occurs prior to or following any Event of Default under
the First Lien Credit Agreement.

     "Lilly" means Eli Lilly and Company, an Indiana corporation.

     "Lilly Payment" means any payment made by the Collection Agent in respect
of any Lilly Shortfall.

     "Lilly Shortfall" means the amount, if any, payable by Quintiles to Lilly
pursuant to the Co-Promotion Agreement that is due and payable but that has not
been paid by Quintiles.

     "Liquidated Damages Amount" has the meaning set forth in Section 8.2(a) of
the Purchase and Sale Agreement.

     "Liquidated Damages Event" means that Quintiles has breached (i) Section
6.2(c), Section 6.2(d) or Section 6.2(e) of the Purchase and Sale Agreement or
(ii) any other covenant in the Purchase and Sale Agreement, but only to the
extent for purposes of this clause (ii) that the actions or inactions giving
rise to such breach result in (x) a termination of the Co-Promotion Agreement
pursuant to the terms of the Co-Promotion Agreement or (y) the failure of Lilly
to make any Royalty Sub Payments required by the Co-Promotion Agreement pursuant
to the terms of the Co-Promotion Agreement for a period of at least six months,
unless Quintiles is in good faith taking appropriate action to contest Lilly's
failure to make such payments under the Co-Promotion Agreement.

                                      A-11
<PAGE>
     "Loan Documents" is defined in the First Lien Credit Agreement.

     "Loan Security Agreement" is defined in the First Lien Credit Agreement.

     "Loans" has the meaning set forth in Section 2.1 of the First Lien Credit
Agreement.

     "Mandatory Redemption" has the meaning set forth in Section 3.1(c) of the
Indenture.

     "Mandatory Repayment Date" is defined in the First Lien Credit Agreement.

     "Material Adverse Development" means (i) any legal or regulatory
development affecting the Product that results in the suspension, withdrawal or
revocation of approvals to sell the Product in the Territory, (ii) any shutdown
for any period in excess of three consecutive months of Lilly's primary and
secondary manufacturing facilities for the production of the Product or any
publicly-announced reduction in manufacturing output of the Product for a period
in excess of three months, (iii) any material adverse re-labeling requirement or
(iv) any voluntary action by Lilly that results in a suspension or cessation of
sales of the Product, the occurrence of any of such items (i) through (iv) which
has, or would reasonably be expected to have, a material adverse effect on the
net sales of the Product on which the Royalty Sub Payments are based.

     "Material Adverse Effect" means a material adverse effect on (i) the
ability of Quintiles, the Pledgor or Servicer, as the case may be, to perform
its obligations under any of the Transaction Documents or the Co-Promotion
Agreement, in each case to which it is a party, (ii) the validity or
enforceability of the Co-Promotion Agreement or the rights or remedies of
Royalty Sub under the Co-Promotion Agreement or (iii) the Royalty Sub Rights or
the ability of Royalty Sub to perform any of its obligations under the Notes,
the Credit Agreement, the Loan Security Agreement and the Indenture.

     "Maximum First Lien Principal Amount" means $125,000,000, less the total
amount of any payments or prepayments of outstanding principal on the Loans,
other than any such payment or prepayment made in connection with a Refinancing.

     "Moody's" means Moody's Investors Service, Inc. and any successor thereto
or, if such corporation or its successor shall for any reason no longer perform
the functions of a securities rating agency, "Moody's" shall be deemed to refer
to any other nationally recognized statistical rating organization (within the
meaning ascribed thereto by the Exchange Act) designated by Royalty Sub.

     "Note Purchase Agreement" means that certain note purchase agreement dated
the Closing Date among Royalty Sub, the Pledgor, Quintiles and the Purchaser
party thereto, including the Annex, Schedule and Exhibits thereto, as amended,
restated, supplemented or otherwise modified from time to time.

     "Note Purchase Agreements" means, collectively, each Note Purchase
Agreement and Other Agreements.

     "Noteholder" means any Person in whose name a Note is registered from time
to time in the Register for such Note.

                                      A-12
<PAGE>
     "Notes" means the Original Class A Notes, any Class B Notes and any
Refinancing Notes.

     "Obligations" is defined in the First Lien Credit Agreement.

     "Obligor" means each of Royalty Sub, the Pledgor and any other Person
(other than Quintiles) granting a Lien on any Collateral pursuant to a First
Lien Collateral Document or a Second Lien Collateral Document.

     "Operating Bank" means U.S. Bank National Association or any other Eligible
Institution consented to by the Collection Agent at which the Accounts are held;
provided, that if at any time the Operating Bank ceases to be an Eligible
Institution, a successor shall be appointed by Servicer on behalf of the
Collection Agent and all Accounts shall thereafter be transferred to and be
maintained at such successor in the name of the Collection Agent and such
successor shall thereafter be the "Operating Bank".

     "Optional Redemption" has the meaning set forth in Section 3.1(a) of the
Indenture.

     "Original Class A Notes" means the Duloxetine PhaRMA(SM) Second Lien 13%
Notes due 2013 of Royalty Sub in the initial Outstanding Principal Balance of
U.S.$125,000,000, substantially in the form of Exhibit A to the Indenture.

     "Other Agreements" has the meaning set forth in Section 3.1 of the Note
Purchase Agreement.

     "Outstanding" means (a) with respect to the Notes of any class at any time,
all Notes of such class theretofore authenticated and delivered by the Trustee
except (i) any such Notes cancelled by, or delivered for cancellation to, the
Trustee, (ii) any such Notes, or portions thereof, for the payment of principal
of and accrued and unpaid interest on which moneys have been distributed to
Noteholders by the Trustee and any such Notes, or portions thereof, for the
payment or redemption of which moneys in the necessary amount have been
deposited in the Repayment/Redemption Account for such Notes; provided, that, if
such Notes are to be redeemed prior to the maturity thereof in accordance with
the requirements of Section 3.1 of the Indenture, written notice of such
Redemption shall have been given as provided in Section 3.2 of the Indenture, or
provision satisfactory to the Trustee shall have been made for giving such
written notice, and (iii) any such Notes in exchange or substitution for which
other Notes, as the case may be, have been authenticated and delivered, or which
have been paid pursuant to the terms of the Indenture (unless proof satisfactory
to the Trustee is presented that any of such Notes is held by a Person in whose
hands such Note is a legal, valid and binding obligation of Royalty Sub), and
(b) when used with respect to the Loans or any other evidence of Indebtedness,
at any time, any principal amount thereof then unpaid and outstanding (whether
or not due or payable).

     "Outstanding Principal Balance" means, with respect to any Note or other
evidence of Indebtedness Outstanding, the total principal amount of such Note or
other evidence of Indebtedness unpaid and Outstanding at any time, as determined
in the case of the Notes in the information to be provided to Servicer, the
Administrative Agent and the Trustee by the Collection Agent pursuant to Section
3.5.

                                      A-13
<PAGE>
     "Participating Second Lien Claimholders" is defined in Section 6.1.

     "Patent Extension Event" means that the Trustee has received written notice
from Servicer that Lilly has received an extension from the United States Patent
and Trademark Office of its compound patent relating to the Product (No.
5,023,269) until at least January 15, 2013.

     "Paying Agent" has the meaning set forth in Section 2.3(a) of the
Indenture.

     "Payment Date" means each January 15, April 15, July 15 and October 15,
commencing on January 15, 2006 and including the Final Maturity Date; provided,
that, if any such date would otherwise fall on a day that is not a Business Day,
the Payment Date falling on such date shall be the first following day that is a
Business Day; provided, further, that, if any such following Business Day would
occur in the succeeding month, then the Payment Date shall be the first Business
Day preceding such date.

     "Permanent Global Note" has the meaning set forth in Section 2.1(b) of the
Indenture.

     "Permanent Regulation S Global Note" has the meaning set forth in Section
2.1(b) of the Indenture.

     "Person" means any natural person, firm, corporation, limited liability
company, partnership, joint venture, association, joint-stock company, trust,
unincorporated organization, Governmental Authority or any other legal entity,
including public bodies, whether acting in an individual, fiduciary or other
capacity.

     "Pledged Collateral" means, as the context may require, (i) any Collateral
in the possession or control of the Collection Agent, the First Lien Agent or
the Trustee, to the extent that possession or control thereof is taken to
perfect a Lien thereon under the UCC and/or (ii) any rights to receive payments
under any insurance policy that constitutes Collateral and with respect to which
the Collection Agent, the First Lien Agent or the Trustee is named as an
additional insured or a loss payee.

     "Pledged Equity" has the meaning set forth in Section 2.1(a) of the Second
Lien Pledge and Security Agreement.

     "Pledgor" is defined in the preamble.

     "Pledgor Bill of Sale" means the Bill of Sale, dated as of the Closing
Date, executed by Quintiles and the Pledgor, substantially in the form of
Exhibit A to the Purchase and Sale Agreement.

     "Premium" means, with respect to any Note on any Redemption Date, any
Redemption Premium, if applicable, or, with respect to any Redemption Date, the
portion of the Redemption Price of the Notes being redeemed in excess of the
Outstanding Principal Balance of the Notes being redeemed.

     "Private Placement Legend" has the meaning set forth in Section 2.2 of the
Indenture.

                                      A-14
<PAGE>
     "Private Placement Memorandum" means the private placement memorandum of
Royalty Sub for the Loans and the Original Class A Notes dated October 14, 2005.

     "Product" means a pharmaceutical product for humans, owned or controlled by
Lilly, containing duloxetine hydrochloride (also known as, according to Chemical
Abstracts' registry #136434-34-9,
(S)-(+)-N-methyl-y-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride) as
the active pharmaceutical ingredient, United States patent numbers 5,023,269 and
5,508,276.

     "Purchase and Sale Agreement" means that certain purchase and sale
agreement dated as of the Closing Date among Quintiles, the Pledgor and Royalty
Sub, including the Annex and Exhibits attached thereto, as amended, restated,
supplemented or otherwise modified from time to time.

     "Purchase Notice" is defined in Section 6.1.

     "Purchaser" has the meaning set forth in Section 1.1 of the Note Purchase
Agreement.

     "Quintiles" means Quintiles Transnational Corp., a North Carolina
corporation.

     "Rate Quotation" means a quotation of the rate at which three-month
deposits in amounts of not less than U.S.$1,000,000 are offered by the Person
quoting such rate to prime banks in the London interbank market, at
approximately 11:00 a.m. London time on the applicable Reference Date, that is
representative of single transactions at such time.

     "Recovery" has the meaning set forth in Section 7.4.

     "Redemption" means any Optional Redemption, any Mandatory Redemption, any
Special Tax Redemption and any other redemption of Notes described in Section
3.1(b) of the Indenture.

     "Redemption Date" means the date, which shall in each case be a Payment
Date, on which Notes are redeemed pursuant to a Redemption.

     "Redemption Premium" means, in the case of any Class B Notes or Refinancing
Notes, the amount, if any, specified in the Board Resolution or indenture
supplemental to the Indenture to be paid in the event of a Redemption of such
Class B Notes or Refinancing Notes separately from the Redemption Price.

     "Redemption Price" means (a) in respect of a Mandatory Redemption or an
Optional Redemption of the Original Class A Notes (i) on any Payment Date on or
prior to April 15, 2008, the greater of (x) the Outstanding Principal Balance of
the Original Class A Notes being redeemed and (y) the present value, discounted
at the Applicable Treasury Rate plus 1.0%, of the scheduled principal payment
amounts not then paid on the Original Class A Notes (assuming the Scheduled
Remaining Notes Balances are achieved as provided in the Class A Principal
Payment Schedule) and interest at the Stated Rate of Interest on the Outstanding
Principal Balance of the Original Class A Notes through January 15, 2011
(assuming the Scheduled Remaining Notes Balances are achieved as provided in the
Class A Principal Payment Schedule) plus, in each case, the accrued and unpaid
interest to the Redemption Date on the Original Class A Notes that

                                      A-15
<PAGE>
are being redeemed and (ii) on any Payment Date after April 15, 2008, an amount
equal to the product of (x) the applicable Class A Redemption Percentage as set
forth below and (y) the Outstanding Principal Balance of the Original Class A
Notes that are being redeemed on such Payment Date, plus the accrued and unpaid
interest to the Redemption Date on the Original Class A Notes that are being
redeemed:

<TABLE>
<CAPTION>
PAYMENT DATES BETWEEN INDICATED PAYMENT DATES        CLASS A REDEMPTION PERCENTAGE
---------------------------------------------        -----------------------------
<S>                                                  <C>
From July 15, 2008 to and including April 15, 2009              106.50%
From July 15, 2009 to and including April 15, 2010              103.25%
        From July 15, 2010 and thereafter                       100.00%
</TABLE>

(b) in respect of any Class B Notes or Refinancing Notes, the redemption price,
if any, plus the accrued and unpaid interest to the Redemption Date on the Class
B Notes or Refinancing Notes, as the case may be, established by or pursuant to
a Board Resolution or in any indenture supplemental to the Indenture providing
for the issuance of such Notes or designated as such in the form of such Notes
(any such Redemption Price in respect of any Class B Notes or Refinancing Notes
may include a Redemption Premium, and such Board Resolution or indenture
supplemental to the Indenture may specify a separate Redemption Premium), and
(c) in respect of a Special Tax Redemption of the Original Class A Notes, 100%
of the Outstanding Principal Balance of the Original Class A Notes plus the
accrued and unpaid interest to the Redemption Date on the Original Class A
Notes.

     "Reference Date" means, with respect to each Interest Accrual Period, the
day that is two Business Days prior to the Payment Date on which such Interest
Accrual Period commences; provided, however, that the Reference Date with
respect to the initial Interest Accrual Period means the date that is two
Business Days before the Closing Date (or, with respect to any Class B Notes or
Refinancing Notes, the date that is two Business Days before the date of
issuance of such Class B Notes or Refinancing Notes).

     "Refinancing" means

          (i) in respect of any Indebtedness under the First Lien Credit
     Agreement, any refinancing, renewal, defeasance, restructuring, replacement
     or refunding of the loans under the First Lien Credit Agreement, to the
     extent (x) the aggregate principal amount of loans and commitments made in
     connection with such refinancing, renewal, defeasance, restructuring,
     replacement or refunding does not exceed the Maximum First Lien Principal
     Amount and (y) the Trustee has been provided written notice by Royalty Sub
     that the Obligations arising from such refinancing, renewal, defeasance,
     restructuring, replacement or refunding are intended to constitute First
     Lien Obligations hereunder (it being understood that the failure of any
     such notice to be given shall not impair or affect the Trustee's or any
     Second Lien Claimholder's obligations to the First Lien Agent and the First
     Lien Claimholders, the First Lien Agent's rights hereunder, the
     enforceability of this Agreement or any Liens created or granted under any
     First Lien Document); provided that any such refinancing, renewal,
     defeasance, restructuring, replacement or refunding (and the Indebtedness
     resulting therefrom) does not (a) contravene the provisions of this
     Agreement or Section 5.1(a) of the Indenture (and the holders of such
     refinancing Indebtedness, or an agent on their behalf, have agreed to be
     bound by the

                                      A-16
<PAGE>
     terms hereof), (b) increase the "Applicable Margin" or similar component of
     the interest or the yield on such Indebtedness by more than 2.0% per annum
     above the "Applicable Margin" or similar component applicable to the Loans
     as of the Closing Date (exclusive, for the avoidance of doubt, of any
     imposition of up to 2.0% of "default" interest) or (c) provide for any
     Indebtedness or other obligations under such refinancing Indebtedness
     becoming due and payable on a date other than the Final Maturity Date; and

          (ii) in respect of any Indebtedness under the Second Lien Documents,
     any refinancing, renewal, defeasance, restructuring, replacement or
     refunding of the Second Lien Notes (including any Refinancing Notes in
     respect thereof) consisting of Refinancing Notes, to the extent (x) the
     aggregate principal amount of the Refinancing Notes issued in connection
     with such refinancing, renewal, defeasance, restructuring, replacement or
     refunding does not exceed the Outstanding Principal Balance as of the
     Closing Date of the Second Lien Notes (or any Refinancing Notes in respect
     thereof) and, together with (for the avoidance of doubt) interest that has
     been accrued and unpaid under the Second Lien Notes (including any
     Refinancing Notes in respect thereof) so refinanced, renewed, defeased,
     restructured, replaced or refunded, any redemption premium provided for in
     the Indenture and reasonable transaction expenses relating thereto and (y)
     the First Lien Agent has been provided written notice by Royalty Sub that
     the obligations arising therefrom are intended to constitute Second Lien
     Obligations hereunder (it being understood that the failure of any such
     notice to be given shall not impair or affect the First Lien Agent's or any
     First Lien Claimholder's obligations to the Trustee and the Second Lien
     Claimholders, the Trustee's rights under the Indenture, the enforceability
     of the Indenture or any Liens created or granted under any Second Lien
     Document); provided that any such refinancing, renewal, defeasance,
     restructuring, replacement or refunding (and the Indebtedness resulting
     therefrom) does not (a) contravene the provisions of this Agreement or
     clause (a) of Section 7.2 of the First Lien Credit Agreement, (b) result in
     an increase in the Stated Rate of Interest or similar component of the
     interest or the yield on the Refinancing Notes than on the Second Lien
     Notes (including any Refinancing Notes in respect thereof), (c) provide for
     dates for payment of principal, interest, premium (if any) or fees which
     are earlier than such dates under the Indenture or the Second Lien Notes
     (including any Refinancing Notes in respect thereof) as in effect on the
     date hereof, (d) provide for covenants, events of default or remedies which
     are more restrictive in any material respect on any Obligor than those set
     forth in the Indenture or the Note Purchase Agreements, in each case as in
     effect on the date hereof, (e) provide for redemption, prepayment or
     defeasance provisions that are more burdensome in any material respect on
     any Obligor than those set forth in the Indenture as in effect on the date
     hereof, (f) provide for collateral securing Secured Obligations thereunder
     which is more extensive than the collateral provided for under the First
     Lien Documents or (g) increase the obligations of any Obligor or confer any
     additional rights on any Second Lien Claimholder which could reasonably be
     expected to be adverse to the First Lien Claimholders in any material
     respect.

          "Refinanced" and "Refinance" shall have correlative meanings of
     Refinancing.

     "Refinancing Notes" means any class of Notes issued by Royalty Sub under
the Indenture at any time and from time to time after the Closing Date pursuant
to Section 2.15 of

                                      A-17
<PAGE>
the Indenture, the proceeds of which are used to repay all of the Outstanding
Principal Balance of a class of Notes.

     "Register" has the meaning set forth in Section 2.3(a) of the Indenture.

     "Registrar" has the meaning set forth in Section 2.3(a) of the Indenture.

     "Regulation S" means Regulation S under the Securities Act.

     "Regulation S Global Note Exchange Date" means the date of exchange of any
Temporary Regulation S Global Note for any Permanent Regulation S Global Note,
which date shall be 40 days after the Closing Date (or, with respect to any
Class B Notes or Refinancing Notes, 40 days after the date of issuance of such
Class B Notes or Refinancing Notes).

     "Regulation S Global Notes" has the meaning set forth in Section 2.1(b) of
the Indenture.

     "Release Event" shall mean (i) prior to the occurrence of an Insolvency or
Liquidation Proceeding by or against any Obligor, the occurrence and continuance
of an Event of Default under the First Lien Credit Agreement and the taking of
any Lien Enforcement Action with respect to the Collateral by the First Lien
Agent; provided, that any Release Event occurring prior to an Insolvency or
Liquidation Proceeding by or against any Obligor shall cease to constitute a
Release Event as of the occurrence of such Insolvency or Liquidation Proceeding
if the First Lien Agent and the First Lien Claimholders continue making loans or
providing other financial accommodations (whether pursuant to the First Lien
Credit Agreement or otherwise) or consent to the use of cash collateral after
the occurrence of such Insolvency or Liquidation Proceeding or (ii) after the
occurrence of an Insolvency or Liquidation Proceeding by or against any Obligor,
the occurrence of any of the following: (a) the entry of an order of the
bankruptcy court pursuant to Section 363 of the Bankruptcy Code or otherwise
authorizing the sale of all or a material portion of any Obligor's assets or (b)
the taking of any Lien Enforcement Action with respect to the Collateral by the
First Lien Agent or the entry of an order of the bankruptcy court pursuant to
Section 362 of the Bankruptcy Code vacating the automatic stay and authorizing
the First Lien Agent to take any Lien Enforcement Action with respect to the
Collateral.

     "Relevant Calculation Date" is defined in clause (a) of Section 3.5.

     "Relevant Information" means any information provided to the Administrative
Agent, the Trustee, the Collection Agent, the Calculation Agent or the Paying
Agent in writing by any Service Provider retained from time to time by Royalty
Sub pursuant to the Transaction Documents.

     "Remaining Weighted Average Life" means, with respect to the Original Class
A Notes on any Redemption Date, (a) the sum of the products of (i) each
principal payment amount on the Original Class A Notes payable on each
subsequent Payment Date (assuming the Scheduled Remaining Notes Balances are
achieved as provided in the Class A Principal Payment Schedule) in accordance
with the Class A Principal Payment Schedule multiplied by (ii) the number of
days remaining from the applicable Redemption Date until such subsequent Payment
Date divided by (b) the Outstanding Principal Balance of the Original Class A
Notes on such Redemption Date.

                                      A-18
<PAGE>
     "Repayment/Redemption Account" is defined in clause (a) of Section 3.1.

     "Required Lenders" means Lenders holding more than 50% of the outstanding
principal amount of all Loans on any date of determination (and without
duplication).

     "Responsible Officer" means (a) with respect to the Administrative Agent,
any officer of the Administrative Agent, (b) with respect to the Trustee, any
officer within the Corporate Trust Office, and also, with respect to a
particular matter, any other officer to whom such matter is referred because of
such officer's knowledge and familiarity with the particular subject, (c) with
respect to Royalty Sub, an officer of Royalty Sub, (d) with respect to the
Pledgor, an officer of the Pledgor and (e) with respect to Quintiles, (i) any
officer of Quintiles and (ii) in respect of the matters described in Section
6.4(d) and Section 6.4(e) of the Purchase and Sale Agreement relating to the
Co-Promotion Agreement, any officer of Quintiles with management
responsibilities in respect of the relationship with Lilly under the
Co-Promotion Agreement.

     "Royalty Sub" is defined in the preamble.

     "Royalty Sub Bill of Sale" means the Bill of Sale, dated as of the Closing
Date, executed by the Pledgor and Royalty Sub, substantially in the form of
Exhibit B to the Purchase and Sale Agreement.

     "Royalty Sub Payments" means all royalties and other compensation, payments
and reimbursements paid, owed, accrued or otherwise required to be paid by Lilly
to Quintiles pursuant to the Co-Promotion Agreement, including (i) all payments
that may be required by (A) Sections 5.6, 5.7, 5.8, 5.13 and 5.14 of the
Co-Promotion Agreement with respect to royalty and other payments, (B) Article
10 of the Co-Promotion Agreement with respect to payments upon certain events of
termination of the Co-Promotion Agreement and (C) Section 11.3 of the
Co-Promotion Agreement with respect to Lilly's continuing responsibility for
paying Quintiles the payments required by Section 5.7 of the Co-Promotion
Agreement in the event of Lilly's license, sale or assignment of its
intellectual property relating to the Product as set forth in such Section 11.3
and (ii) additional payments or consideration paid to Quintiles in connection
with any amendment, restatement, supplement, modification or waiver of the
Co-Promotion Agreement.

     "Royalty Sub Rights" means the assets sold, transferred, conveyed,
assigned, contributed and granted by Quintiles to the Pledgor, and by the
Pledgor to Royalty Sub, pursuant to the Purchase and Sale Agreement and the
respective Bill of Sale, which shall consist of (i) the rights of Quintiles
under the Co-Promotion Agreement (A) to receive all Royalty Sub Payments and (B)
to receive quarterly net sales reports under Section 5.10 of the Co-Promotion
Agreement from Lilly showing net sales for such quarter and (ii) the proceeds of
and the rights to enforce each of the foregoing.

     "Rule 144A" means Rule 144A under the Securities Act.

     "S&P" means Standard & Poor's Ratings Services, a division of The
McGraw-Hill Companies, Inc., and any successor thereto or, if such division or
its successor shall for any reason no longer perform the functions of a
securities rating agency, "S&P" shall be deemed to refer to any other nationally
recognized statistical rating organization (within the meaning ascribed thereto
by the Exchange Act) designated by Royalty Sub.

                                      A-19
<PAGE>
     "Scheduled Remaining Notes Balance" means for any Payment Date the
remaining Outstanding Principal Balance of the Original Class A Notes for such
Payment Date as set forth on the Class A Principal Payment Schedule.

     "Second Lien Claimholders" means, at any relevant time, the holders of
Second Lien Obligations at such time.

     "Second Lien Collateral" means all of the assets and property of any
Obligor, whether real, personal or mixed, with respect to which a Lien is
granted by such Obligor as security for any Second Lien Obligations.

     "Second Lien Collateral Documents" means, collectively, the Indenture, the
Second Lien Pledge and Security Agreement and any other agreement, document or
instrument pursuant to which a Lien is granted securing any Second Lien
Obligations or under which rights or remedies with respect to such Liens are
governed.

     "Second Lien Documents" means the Notes, the Note Purchase Agreements and
the Second Lien Collateral Documents, including any documents or instruments
executed or delivered in connection with a Refinancing.

     "Second Lien Notes" is defined in the recitals.

     "Second Lien Obligations" means all Secured Obligations outstanding under
the Indenture, the Notes and the other Second Lien Documents. "Second Lien
Obligations" shall include all interest accrued or accruing (or which would,
absent commencement of an Insolvency or Liquidation Proceeding, accrue) after
commencement of an Insolvency or Liquidation Proceeding in accordance with the
rate specified in the relevant Second Lien Document whether or not the claim for
such interest is allowed as a claim in such Insolvency or Liquidation
Proceeding. To the extent any payment with respect to the Second Lien
Obligations (whether by or on behalf of any Obligor, as proceeds of security,
enforcement of any right of setoff or otherwise) is declared to be fraudulent or
preferential in any respect, set aside or required to be paid or turned over to
a debtor in possession, trustee, receiver or similar Person, then the obligation
or part thereof originally intended to be satisfied shall be deemed to be
reinstated and outstanding as if such payment had not occurred.

     "Second Lien Pledge and Security Agreement" means that certain second lien
pledge and security agreement dated as of the Closing Date made by the Pledgor
to the Trustee pursuant to the terms of the Indenture, including the Annex and
Exhibits attached thereto, as amended, restated, supplemented or otherwise
modified from time to time.

     "Secured Creditors" means the First Lien Agent, the First Lien
Claimholders, the Trustee and the Second Lien Claimholders.

     "Secured Obligations" has the meaning set forth in the Granting Clause of
the Indenture.

     "Secured Party" has the meaning set forth in the Credit Agreement.

     "Securities Act" means the U.S. Securities Act of 1933, as amended.

                                      A-20
<PAGE>
     "Senior Class" means (a) so long as any Class A Notes are Outstanding, the
Class A Notes, or (b) if no Class A Notes are Outstanding, the Class B Notes.

     "Service Providers" means Servicer, the Administrative Agent, the Trustee,
the Collection Agent, the Calculation Agent, the Paying Agent, the Registrar,
the Operating Bank and any Person that becomes Servicer, the Administrative
Agent, the Trustee, the Collection Agent, the Calculation Agent, the Paying
Agent, the Registrar or the Operating Bank in accordance with the terms of the
applicable agreement and, subject to the written approval of the Administrative
Agent or, after the Discharge of First Lien Obligations, the Noteholders of a
majority of the Outstanding Principal Balance of the Senior Class of Notes, any
other Person designated as a Service Provider by Royalty Sub.

     "Servicer" means Quintiles, acting in its capacity as servicer pursuant to
the Servicing Agreement (or any other Person appointed by Royalty Sub to succeed
Quintiles as such or any successor thereto).

     "Servicer Information" means, with respect to any Calculation Date, the
written information provided by Servicer under Section 4.1(c) of the Servicing
Agreement with respect to such Calculation Date.

     "Servicing Agreement" means the servicing agreement dated as of the Closing
Date between Royalty Sub and Quintiles, including the Annex attached thereto, as
amended, restated, supplemented or otherwise modified from time to time in
accordance with the terms of the Credit Agreement and the Indenture, if
applicable.

     "Shortfall" has the meaning set forth in clause (a)(xiv) of Section 3.5.

     "Special Tax Redemption" has the meaning set forth in Section 3.1(d) of the
Indenture.

     "Stated Rate of Interest" means, with respect to any class of the Notes for
any Interest Accrual Period, the interest rate set forth in such class of Notes
for such Interest Accrual Period.

     "Subsidiary" means, with respect to any Person, any other Person of which
more than 50% of the outstanding Voting Securities of such other Person
(irrespective of whether at the time Capital Securities of any other class or
classes of such other Person shall or might have voting power upon the
occurrence of any contingency) is at the time directly or indirectly owned or
controlled by such Person, by such Person and one or more other Subsidiaries of
such Person or by one or more other Subsidiaries of such Person.

     "Taxes" means any and all taxes, fees, levies, duties, tariffs, imposts and
other charges of any kind (together with any and all interest, penalties, loss,
damage, liability, expense, additions to tax and additional amounts or costs
incurred or imposed with respect thereto) now or hereafter imposed, levied,
collected, withheld or otherwise assessed by the U.S. or by any state, local,
foreign or other Governmental Authority (or any subdivision or agency thereof)
or other taxing authority, including taxes or other charges on or with respect
to income, franchises, windfall or other profits, gross receipts, property,
sales, use, capital stock, payroll, employment, social security, workers'
compensation, unemployment compensation or net worth and similar charges and
taxes or other charges in the nature of excise, deduction, withholding, ad
valorem, stamp,

                                      A-21
<PAGE>
transfer, value added, taxes on goods and services, gains taxes, license,
registration and documentation fees, customs duties, tariffs and similar
charges.

     "Telerate Page 3750" means Page 3750 on Moneyline Telerate or such other
page as may replace Page 3750 on that service or such other service as may be
nominated by the British Bankers' Association for the purpose of displaying
London interbank offered rates for U.S. dollar deposits.

     "Temporary Regulation S Global Note" has the meaning set forth in Section
2.1(b) of the Indenture.

     "Territory" means the 50 states of the United States of America and the
District of Columbia, but does not include the Commonwealth of Puerto Rico or
any other territory, possession or protectorate of the United States of America.

     "Transaction" is defined in the First Lien Credit Agreement.

     "Transaction Documents" means the Credit Agreement, the Indenture, the
Notes, the Purchase and Sale Agreement, the Bill of Sale, the Servicing
Agreement, the First Lien Pledge and Security Agreement, the Second Lien Pledge
and Security Agreement, the Loan Security Agreement, this Agreement, the Note
Purchase Agreements, the account control agreement dated as of October 18, 2005
among Royalty Sub, Servicer, the Administrative Agent, the Trustee and U.S. Bank
National Association, as custodian thereunder, and each other agreement pursuant
to which the Administrative Agent or the Trustee (or its respective agents) is
granted a Lien to secure the obligations under the Credit Agreement, the
Indenture or the Notes, respectively.

     "Transaction Expenses" means the out-of-pocket expenses payable by Royalty
Sub in connection with (a) the issuance of the Loans and the Original Class A
Notes, including placement fees, any initial fees payable to Service Providers
and the fees and expenses of Mayer, Brown, Rowe & Maw LLP and Pillsbury Winthrop
Shaw Pittman LLP, counsel to the Administrative Agent and the Noteholders,
respectively, in connection with the making of the Loans and the offering and
issuance of the Original Class A Notes, as set forth in the Credit Agreement and
the Note Purchase Agreements, respectively, and (b) the offering and issuance of
any Class B Notes or Refinancing Notes, to the extent specified in the Board
Resolution authorizing such offering and issuance.

     "Trigger Notice" has the meaning set forth in Section 6.1.

     "Trust Indenture Act" means the U.S. Trust Indenture Act of 1939, as
amended.

     "Trustee" has the meaning set forth in the preamble hereof, and includes
any agent acting on its behalf.

     "Trustee Closing Account" means the account of Royalty Sub maintained with
the Trustee at U.S. Bank, ABA No. 091000022, Account No. 173103321092, Ref.
Duloxetine Royalty (Acct. # 173103321092), Attention: Corporate Trust (Zlatan
Catic/Alice Menezes).

                                      A-22
<PAGE>
     "UCC" means the Uniform Commercial Code as in effect from time to time in
the State of New York; provided, that, if, with respect to any financing
statement or by reason of any provisions of law, the perfection or the effect of
perfection or non-perfection of the Liens granted to the Administrative Agent or
the Trustee pursuant to the applicable Transaction Document is governed by the
Uniform Commercial Code as in effect in a jurisdiction of the United States
other than the State of New York, then "UCC" means the Uniform Commercial Code
as in effect from time to time in such other jurisdiction for purposes of the
provisions of each Transaction Document and any financing statement relating to
such perfection or effect of perfection or non-perfection.

     "U.S." or "United States" means the United States of America, its 50
states, each territory thereof and the District of Columbia.

     "Voting Securities" means, with respect to any Person, Capital Securities
of any class or kind ordinarily having the power to vote for the election of
directors, managers or other voting members of the governing body of such
Person.

                                      A-23
<PAGE>
                                     ANNEX B

                         COVERAGE OF DISTRIBUTION REPORT

(i)  With respect to the current Payment Date, (A) the balances on deposit in
     the Collection Account and any other Account established under the
     Intercreditor Agreement on the Calculation Date immediately preceding the
     prior Payment Date (or, with respect to the first Payment Date, on the
     Closing Date) (the "Preceding Calculation Date"), (B) the aggregate amounts
     of deposits into and withdrawals from the Collection Account and any other
     Account established under the Intercreditor Agreement from but excluding
     the Preceding Calculation Date to and including the Calculation Date
     immediately preceding the Payment Date (the "Current Calculation Date") and
     (C) the balances on deposit in the Collection Account and any other Account
     established under the Intercreditor Agreement on the Current Calculation
     Date.

(ii) Analysis of Collection Account activity from the Preceding Calculation Date
     to the Current Calculation Date

     Balance on the Preceding Calculation Date

     Collections from but excluding the Preceding Calculation Date to and
     including the Current Calculation Date ("Current Collections")

     Aggregate Loan and other First Lien Document payments from but excluding
     the Preceding Calculation Date to and including the Current Calculation
     Date

     Aggregate Note payments from but excluding the Preceding Calculation Date
     to and including the Current Calculation Date

     Expense payments payable on the Current Calculation Date ("Current
     Expenses")

     Balance on the Current Calculation Date

(iii) Interest Coverage Ratio

     Current Collections

     Interest due on the Outstanding Principal Balance of the Notes for the
     current Payment Date plus Current Expenses

     Interest Coverage Ratio for the current Payment Date

     Required Interest Coverage Ratio for the current Payment Date

(iv) Amount, if any, to be transferred from the Holding Account to the
     Collection Account with respect to the current Payment Date

(v)  Payments on the current Payment Date

     Current Expenses

     Interest Amount of Loans

     Interest Amount of Notes

     Additional interest on Loans, if any

     Additional Interest, if any

     Principal payments of Loans and other obligations under First Lien
     Documents

     Principal payments of Notes, if any

                                       B-1
<PAGE>
     Amounts transferred to the Holding Account, if any

(vi) Aggregate principal amount of Loans

     Opening balance

     Principal payments made on the current Payment Date

     Closing balance

(vii) Outstanding Principal Balance of Notes

     Opening Outstanding Principal Balance

     Principal payments, if any, made on the current Payment Date

     Closing Outstanding Principal Balance

(viii) Amount distributed to Royalty Sub from the Collection Account, if any,
     with respect to the current Payment Date

(ix) Amount distributed to Royalty Sub from the Holding Account, if any, with
     respect to the current Payment Date

(x)  A comparison of the actual Outstanding Principal Balance of the Notes to
     the Scheduled Remaining Notes Balance as of the current Payment Date

(xi) A withholding obligation may be included

(xii) Appropriate modifications will be made to contemplate any Refinancing
     Notes and/or Class B Notes

                                       B-2

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