Document:

EXHIBIT 4.3

                                 FORM OF WARRANT

THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED. SUCH SECURITIES MAY NOT BE SOLD, ASSIGNED, TRANSFERRED,
PLEDGED OR HYPOTHECATED UNLESS REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, OR IN ACCORDANCE WITH AN EXEMPTION THEREUNDER.

                                 68,000 Warrants

            Void after 5:00 p.m. Eastern Time on the Expiration Date

                        WARRANT TO PURCHASE COMMON STOCK

                                       OF

                       NASTECH PHARMACEUTICAL COMPANY INC.

      This Is To Certify That, FOR VALUE RECEIVED, Jesup & Lamont Securities
Corporation ("Holder"), having an address at 650 Fifth Avenue, Suite 300, New
York, NY 10019, is entitled to purchase, subject to the provisions of this
Warrant, ("Warrant") from Nastech Pharmaceutical Company Inc., a Delaware
corporation (the "Company"), Sixty-Eight Thousand (68,000) non-callable, fully
paid, validly issued and non-assessable shares of Common Stock, par value $.006
per share (the "Common Stock"), at an exercise price of $9.56, at any time or
from time to time during the period (the "Exercise Period") from the date hereof
until 5:00 p.m. Eastern Standard Time on May 11, 2005 (the "Expiration Date").
The number of shares of Common Stock to be received upon the exercise of this
Warrant and the price to be paid for each share of Common Stock may be adjusted
from time to time as hereinafter set forth. The Common Stock, as adjusted from
time to time, are hereinafter sometimes referred to as "Warrant Shares" and the
exercise price of the Common Stock hereunder in effect at any time and as
adjusted from time to time is hereinafter sometimes referred to as the "Exercise
Price."

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      (1) EXERCISE OF WARRANT. This Warrant may be exercised in whole or in part
at any time or from time to time during the Exercise Period; provided, however,
that if such day is a day on which banking institutions in the State of New York
are authorized by law to close, then on the next succeeding day which shall not
be such a day. This Warrant may be exercised by presentation and surrender of
this Warrant to the Company at its principal office or to the Company's warrant
agent, if any has been so appointed, with the Exercise Form annexed hereto duly
executed and accompanied by payment of the Exercise Price, in cash or by
certified or bank cashier's check, for the number of Warrant Shares specified in
such form. Notwithstanding the foregoing, in lieu of any cash payment required
hereunder, the Holder of this Warrant shall have the right at any time during
the Exercise Period to exercise the Warrant in full or in part by surrender of
this Warrant (with the election at the end hereof duly executed) to the Company
at its principal office or to the Company's warrant agent, if any has been so
appointed, in exchange for the number of Warrant Shares equal to the product of
(a) the number of Warrant Shares as to which the Warrant is being exercised
multiplied by (b) a fraction, the numerator of which is the Current Market Price
(as defined in Section 10 below) of the Common Stock less the Exercise Price and
the denominator of which is the Current Market Price. As soon as practicable
after each such exercise of the Warrants, the Company shall issue or cause to be
issued and delivered to the Holder a certificate or certificates for the Warrant
Shares issuable upon such exercise, registered in the name of the Holder. The
Warrant shall be deemed to have been exercised immediately prior to the close of
business on the date of any such exercise, provided such exercise is in
accordance with the provisions set forth herein. If this Warrant should be
exercised in part only, the Company shall, upon surrender of this Warrant for
cancellation, execute and deliver a new Warrant evidencing the rights of the
Holder thereof to purchase the balance of the Warrant Shares purchasable
thereunder. Upon receipt by the Company of this Warrant at its office in proper
form for exercise, the Holder shall be deemed to be the holder of record of the
Common Stock issuable upon such exercise, notwithstanding that the stock
transfer books of the Company shall then be closed or that certificates
representing such Common Stock shall not then be physically delivered to the
Holder.

      (2) RESERVATION OF SHARES. The Company shall at all times reserve for
issuance and/or delivery upon exercise of this Warrant such number of shares of
its Common Stock as shall be required for issuance and delivery upon exercise of
the Warrants.

      (3) FRACTIONAL SHARES. No fractional shares or script representing
fractional shares shall be issued upon the exercise of this Warrant. If more
than one Warrant shall be exercised at one time by the Holder, the number of
full shares which shall be issuable upon exercise thereof shall be computed on
the basis of the aggregate number of full shares issuable upon such exercise. No
adjustment shall be made in respect of cash dividends on Warrant Shares
delivered upon exercise of any Warrant. With respect to any fraction of a share
called for upon exercise hereof, the Company shall pay to the Holder an amount
in cash equal to such fraction multiplied by the average bid and asked prices of
the Common Stock on the last available date for which quotations are available
immediately preceding the date of exercise of this Warrant, if the bid and asked
prices are not so reported, then the current market value shall be an amount,
not less than the book value thereof as at the end of the most recent fiscal
year of the Company ending prior to the date of the exercise of the Warrant,
determined in such reasonable manner as may be prescribed by the Board of
Directors of the Company.

      (4) EXCHANGE OR LOSS OF WARRANT. This Warrant is exchangeable, without
expense, at the option of the Holder, upon presentation and surrender hereof to
the Company for other Warrants of different denominations entitling the holder
thereof to purchase in the aggregate the same number of Common Stock purchasable
hereunder. This Warrant may be divided or combined with other Warrants which
carry the same rights upon presentation hereof at the principal office of the
Company with a written notice specifying the denominations in which new Warrants
are to be issued and signed by the Holder hereof. The term "Warrant" as used
herein includes any Warrants into which this Warrant may be divided or
exchanged. Upon receipt by the Company or its warrant agent, if any, of evidence
satisfactory to it of the loss, theft, destruction or mutilation of this
Warrant, and (in

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the case of loss, theft or destruction) of reasonably satisfactory
indemnification, and upon surrender and cancellation of this Warrant, if
mutilated, the Company will execute and deliver a new Warrant of like tenor and
date.

      (5) RIGHTS OF THE HOLDER. The Holder shall not, by virtue hereof, be
entitled to any rights of a stockholder in the Company, either at law or equity,
and the rights of the Holder are limited to those expressed in the Warrant and
are not enforceable against the Company except to the extent set forth herein
and in any warrant agreement entered into by and between the Company and a
warrant agent with respect to the Warrants. In the event the Company enters into
a warrant agreement with a warrant agent, the terms of the Warrant shall be
embodied in the warrant agreement; and the acceptance of this Warrant by the
Holder shall be deemed consent by the Holder for the Company to enter into any
such warrant agreement, upon such terms and conditions mutually agreeable
between the Company and any such warrant agent, provided such warrant agreement
does not adversely affect any of the rights of the Holder, as set forth in this
Warrant.

      (6) ANTI-DILUTION PROVISIONS.

            (a) Stock Dividends, Splits, Combinations, etc. In case the Company
shall at any time after the date of this Warrant (i) declare a dividend, or make
a distribution, on the outstanding Common Stock in shares of its capital stock,
(ii) subdivide the outstanding Common Stock, (iii) combine the outstanding
Common Stock into a smaller number of shares, or (iv) issue any shares of its
capital stock by reclassification of the Common Stock (including any such
reclassification in connection with a consolidation or merger in which the
Company is the continuing corporation), then in each case, the number and kind
of shares of Common Stock receivable upon exercise of this Warrant, in effect at
the time of the record date for such dividend or distribution or of the
effective date of such subdivision, combination, or reclassification, shall be
proportionately increased or decreased, as the case may be, so that the Holder
after such time shall be entitled to receive the aggregate number and kind of
shares which if such Warrant had been exercised immediately prior to such time,
it would have owned upon such exercise and been entitled to receive by virtue of
such dividend, distribution, subdivision, combination or reclassification.
Whenever the number of shares of Common Stock purchasable upon the exercise of
this Warrant is adjusted as provided in this Section 6(a), then the Exercise
Price shall also be adjusted by multiplying such Exercise Price immediately
prior to such adjustment by a fraction (A) the numerator of which shall be the
number of shares of common Stock purchasable upon the exercise immediately prior
to such adjustment, and (B) the denominator of which shall be the number of
shares of Common Stock so purchasable immediately thereafter. Such adjustment
shall be made successively whenever any event listed above shall occur.

            (b) Reorganization, Consolidation, Merger, Etc. In the case of any
reorganization of the Company (or any other corporation, the securities of which
are at the time receivable on the exercise of this Warrant) or if the Company
(or any other such corporation) shall consolidate with or merge into another
corporation or convey all or substantially all of its assets to another
corporation, then, and in each such case, the Holder of this Warrant upon the
exercise as provided for in Section 1 at any time after the consummation of such
reorganization, consolidation, merger or conveyance, shall be entitled to
receive in lieu of the securities and property receivable upon the exercise of
this Warrant prior to such consummation, the securities or property to which
such Holder would have been entitled upon such consummation if such Holder had
exercised this Warrant immediately prior thereto, in each such case, the terms
of this Warrant shall be applicable to the securities or property received upon
the exercise of this Warrant after such combination.

            (c) Extraordinary Dividends. In case the Company shall distribute to
all holders of Common Stock (including any such distribution made to the
stockholders of the Company in connection with a consolidation or merger in
which the Company is the continuing corporation) evidences of its indebtedness
or assets (other than dividends payable in shares of Common Stock), or
subscription rights, options, or warrants or convertible or exchangeable
securities containing the right to subscribe for or purchase shares of Common
Stock (excluding those referred to in paragraph 6(b) hereof), then, in each
case, the Exercise Price shall be adjusted by multiplying the Exercise Price in
effect immediately prior to the record date for the determination of
stockholders entitled to receive

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such distribution by a fraction, the numerator of which shall be the current
Exercise Price per share of Common Stock on such record date, less the fair
market value (as determined in good faith by the Board of Directors of the
Company, whose determination shall be conclusive absent manifest error) of the
portion of the evidences of indebtedness or assets so to be distributed, or of
such subscription rights, options, or warrants or convertible or exchangeable
securities containing the right to subscribe for or purchase shares of Common
Stock, applicable to one share, and the denominator of which shall be such
current Exercise Price per share of Common Stock. Such adjustment shall be made
whenever any such distribution is made, and shall become effective on the date
of such distribution retroactive to the record date for the determination of
stockholders entitled to receive such distribution.

            (d) De Minimis Exception. No adjustment in the Exercise Price shall
be required if such adjustment is less than $.01; provided, however, that any
adjustments which by reason of this paragraph 6 are not required to be made
shall be carried forward and taken into account in any subsequent adjustment.
All calculations under this paragraph 6 shall be made to the nearest
one-thousandth of a share, as the case may be.

            (e) Date of Issuance. In any case in which this paragraph 6 shall
require that an adjustment in the Exercise Price be made effective as of a
record date for a specified event, the Company may elect to defer, until the
occurrence of such event, issuing to any Holder who exercised any Warrants after
such record date, the shares of Common Stock, if any, issuable upon such
exercise over and above the shares of Common Stock, if any, issuable upon such
exercise on the basis of the Exercise Price in effect prior to such adjustment.

            (f) Adjustment to Number of Shares. Upon each adjustment of the
Exercise Price as a result of the calculations made in paragraph 6(c) hereof,
each Warrant outstanding prior to the making of the adjustment in the Exercise
Price shall thereafter evidence the right to purchase, at the adjusted Exercise
Price, that number of shares (calculated to the nearest thousandth) obtained by
dividing (i) the product obtained by multiplying the number of shares
purchasable upon exercise of a Warrant prior to adjustment of the number of
shares by the Exercise Price in effect prior to adjustment of the Exercise Price
by (ii) the Exercise Price in effect after such adjustment of the Exercise
Price.

            (g) Notice of Adjustments. Whenever there shall be an adjustment as
provided in this paragraph 6, the Company shall promptly cause written notice
thereof to be sent by overnight courier, to the Holder, at its principal office,
which notice shall be accompanied by an officer's certificate setting forth the
number of Warrant Shares purchasable upon the exercise of this Warrant and the
Exercise Price after such adjustment and setting forth a brief statement of the
facts requiring such adjustment and the computation thereof, which officer's
certificate shall be conclusive evidence of the correctness of any such
adjustment absent any error.

            (h) Outstanding Options/Warrants. No adjustment in the Exercise
Price shall be required in the case of the issuance of any and all shares of
Common Stock upon exercise of any options, warrants or convertible securities
outstanding on or before the date hereof.

            (i) Adjustments at Below Par Value. Before taking any action which
would cause an adjustment reducing the Exercise Price below the then par value
of the Common Stock issuable upon exercise of the Warrants, the Company will
take any corporate action which may, in the opinion of its counsel, be necessary
in order that the Company may validly and legally issue fully paid and
non-assessable shares of such the Company at such adjusted Exercise Price.

      (7) INVESTMENT REPRESENTATION. By accepting this Warrant, the Holder
acknowledges that it is being taken for its own account as principal, for
investment purposes only, and not with a view to, or for, resale, distribution
or fractionalization thereof, in whole or in part, and no other person has a
direct or indirect beneficial interest in such Warrant; and such Warrant may
only be transferred, subject to compliance with the legend set forth on the
first page of this Warrant Certificate. Purchaser will not, directly or
indirectly, offer, sell, pledge, transfer or otherwise dispose of (or solicit
any offers to buy, purchase or otherwise acquire or take a pledge of) the
Warrant,

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except in compliance with the Securities Act and the rules and regulations
promulgated thereunder. Holder is an "Accredited Investor" as defined in Rule
501 of Regulation D under the Securities Act. Holder is aware of the Company's
business affairs and financial condition and has had access to and has acquired
sufficient information about the Company to reach an informed and knowledgeable
decision to acquire the Warrant. Holder has such business and financial
experience as is required to give it the capacity to utilize the information
received, to evaluate the risks involved in purchasing the Warrant and making an
informed decision about purchasing the Warrant, and to protect its own interests
in connection with the purchase of the Warrant and is able to bear the risks of
an investment in the Warrant. Purchaser is not an "affiliate" or the Company as
defined in Rule 405 of the Securities Act. Holder understands that its
acquisition of the Warrant has not been registered under the Securities Act of
1933 or registered or qualified under any state securities law in reliance on
specific exemptions therefrom, which exemptions may depend upon, among other
things, the bona fide nature of Holder's investment intent as expressed herein.
Holder has, in connection with its decision to purchase the Warrant, relied
solely upon the representations and warranties of the Company contained herein.
Unless the shares issuable upon the exercise of this Warrant are registered
under the Securities Act, the Holder, upon exercise of this Warrant, will be
required to reiterate the representations contained in this Section 7 with
respect to the shares so issuable, and the certificates representing such shares
will contain a legend to the effect that the Holder may not transfer, sell,
pledge or hypothecate such shares unless the registration provisions of the
Securities Act have been complied with and unless the Company has received an
opinion of counsel that such registration is not required.

      (8) REGISTRATION RIGHTS. The Company will register the Warrant Shares for
resale by the Holder on the first registration statement that the Company files
with the Commission after October 18, 2001. Any registration statement filed
pursuant to this Section 8 shall be maintained and remain effective during the
term of this Warrant.

      (9) NOTICES. All notices and other communications which are required or
may be given under this Warrant shall be in writing and shall be deemed to have
been duly given when delivered in person or transmitted by telex or three (3)
days after being mailed, postage prepaid, in the case of the Company to Nastech
Pharmaceutical Company Inc., 45 Adams Avenue, Hauppauge, New York 11788
Attention: Chief Financial Officer, and in the case of the Holder to the address
set forth herein, or to such other address as such party shall have specified by
notice to the other party in accordance with this section (9). If notice is
given by registered or certified first class mail, postage prepaid, return
receipt requested, the return receipt shall be conclusive evidence of the notice
having been mailed on the date set forth.

      (10) DEFINITION. The "Current Market Price" for the Common Stock of the
Company on any date shall be deemed to be the average of the daily closing
prices for the thirty (30) consecutive trading days immediately preceding the
date in question. The closing price for each day shall be the last reported
sales price regular way or, in case no such reported sale takes place on such
day, the closing bid price regular way, in either case on the principal national
securities exchange (including, for purposes hereof, the Nasdaq National Market
("Nasdaq")) on which the shares of Common Stock are listed or admitted to
trading, or, if the Common Stock are not listed or admitted to trading on any
national securities exchange, the highest reported bid price for the Common
Stock as furnished by the Nasdaq or a similar organization if the Nasdaq is no
longer reporting such information (including, for purposes hereof, Nasdaq). If
on any such date the Common Stock are not listed or admitted to trading on any
national securities exchange and are not quoted by Nasdaq or any similar
organization, the fair value of a share on such date, as determined in good
faith by the Board of Directors of the Company, whose determination shall be
conclusive, shall be used.

      (11) MISCELLANEOUS. This Agreement contains the entire Agreement and
supersedes all prior agreements and understandings, oral or written, between the
parties hereto with respect to the subject matter hereof. This Warrant may not
be changed orally, but only by an agreement in writing signed by the party
against whom any waiver, change, amendment, modification or discharge is sought,
provided however, that this Warrant may be amended or modified without the
consent of the Holder if such amendment or modification does not adversely
affect

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the rights of the Holder hereunder. This Agreement may be assigned by Holder in
accordance with the provisions of section (7) of this Agreement. This Agreement
will not be assigned by the Company and shall be interpreted under the laws of
the State of New York without application to the principles of conflicts of
laws.

                                    NASTECH PHARMACEUTICAL COMPANY INC.

                               By: ___________________________________________

Dated: October 18, 2001

Attest:

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                               FORM OF ASSIGNMENT

            (To be executed by the registered holder if such holder desires to
transfer the attached Warrant.)

            FOR VALUE RECEIVED, _____________________ hereby sells, assigns, and
transfers unto ________________________ a warrant (the "Warrant") to purchase
__________ Common Stock, $.006 par value per share, of Nastech Pharmaceutical
Company Inc. (the "Company"), together with all right, title, and interest
therein, and does hereby irrevocably constitute and appoint
__________________________________________________ as attorney to transfer such
Warrant on the books of the Company, with full power of substitution.

Dated:___________________

                                                Signature:  ___________________

                                     NOTICE

            The signature on the foregoing Assignment must correspond to the
name as written upon the face of this Warrant in every particular, without
alteration or enlargement or any change whatsoever.

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                                  EXERCISE FORM

                                  Dated ______, ____

      The undersigned hereby irrevocably elects to exercise the within Warrant
to the extent of purchasing shares of Common Stock and hereby (i) tenders
payment herewith in the amount of $_____________ or (ii) surrenders this Warrant
in the amount of _________, in payment of the actual exercise price thereof, and
requests that certificates for such securities be issued in the name of, and
delivered to, and, if such number of Warrant Shares shall not be all the Warrant
Shares covered by the within Warrant, that a new Warrant for the balance of the
Warrant Shares be registered in the name of, and delivered to, the undersigned
at the address stated below. As a condition to this election, the undersigned
hereby represents and warrants to the Company that the representations made by
the undersigned in Section 7 of the Warrant are true and correct as of the date
of this election with respect to the Warrant Shares.

                     INSTRUCTIONS FOR REGISTRATION OF STOCK

Name: __________________________________________________________________________
                 (Please type, write or print in block letters)

Address: _______________________________________________________________________

Signature: _____________________________________________________________________Exhibit 10.A
                                  COVANCE INC.
                           VARIABLE COMPENSATION PLAN
                            Effective January 1, 2001

1.       Purpose: The purpose of the Covance Inc. Variable Compensation Plan (as
         amended, modified or supplemented, from time to time, the "Plan") is to
         reward the accomplishments of participating employees of Covance Inc.
         ("Covance") and its subsidiaries (collectively, the "Company") in
         achievement of company performance versus targets. The Plan does not
         constitute an amendment, supplement or modification of any individual
         employment agreement between the Company and an employee.

2.       Eligibility: Variable compensation awards under the Plan may be made to
         individuals who are full-time or part-time employees of the Company
         (including executives of the Company) provided that:

         (a)  The employee is employed with the Company on or before October 1
              of the performance year in question; provided, however, that in
              the event an individual commences employment with the Company
              after October 1 of the performance year in question but otherwise
              satisfies the eligibility or performance requirements of the
              Plan, then a variable compensation award may be made upon the
              chief executive officer's ("CEO") recommendation. If the employee
              commences employment with the Company after January 1 of the
              performance year in question but before October 1 of such year and
              otherwise satisfies the eligibility or performance requirements of
              the Plan, then such employee's variable compensation award, if
              any, shall be prorated based on the actual service provided by the
              employee for the performance year in question based either on time
              worked or base pay earned.

         (b)  In the case of Individual Contributor employees (as defined in
              Appendix 2), the employee is employed by the Company on December
              15 of the performance year and, in the case of other employees,
              the employee is employed by the Company both on December 31 of
              the performance year and on the payment date (usually mid-March
              of the following calendar year), provided, however, that (i) in
              the event an employee leaves the Company as a result of death or
              disability the employee shall be eligible for an award which
              shall be prorated based on actual service provided by the
              employee for the performance year in question based on time
              worked or base pay earned in the performance year in question; and
              (ii) in the event a Manager/Supervisor or Key Executive employee's
              employment is terminated by the Company due to a reduction in
              force between December 31 and the payment date, the employee shall
              be eligible for an award.

         (c)  With respect to Individual Contributor employees, the employee is
              in good standing, not on probation or involved in a formal work
              improvement program on the payment date; and

         (d)  The employee is not eligible to participate in any other Company
              variable compensation plan, sales compensation plan or other
              similar plan.
<PAGE>

3.       Administration/Disputes: The Compensation and Organization Committee of
         the Covance Board of Directors (the "Committee"), consisting of at
         least two members who qualify as outside directors under applicable
         Internal Revenue Code and Securities and Exchange Commission (the
         "SEC") rules, codes and regulations, shall manage and administer the
         Plan. No member of the Committee shall be eligible for awards under the
         Plan. The Committee may adopt such policies, rules and regulations that
         it deems necessary for governing, managing or administering the Plan.
         To the extent consistent with the Company's Amended and Restated
         Certificate of Incorporation, no member of the Committee shall be
         liable for any action or determination with respect to the Plan, and
         the members shall be entitled to indemnification and reimbursement in
         the manner provided in the Company's Amended and Restated Certificate
         of Incorporation, as amended, modified or supplemented from time to
         time. In the performance of its functions under the Plan, the Committee
         shall be entitled to rely upon information and advice furnished by the
         Company's officers, accountants, counsel and any party the Committee
         deems necessary, and no member of the Committee shall be liable for any
         action taken or not taken in reliance upon any such advice. Any dispute
         or disagreement which shall arise under, or as a result of, or pursuant
         to, this Plan shall be finally determined by the Committee in its
         absolute and uncontrolled discretion, and any such determination or any
         other determination by the Committee under or pursuant to this Plan and
         any interpretation by the Committee of the terms of this Plan, shall be
         final, binding and conclusive on all persons affected thereby.

4.       Performance Year: The plan year is from January 1 through December 31.

5.       Performance Targets:

         (a)  Business Units. The CEO shall propose for the approval of the
              Committee the performance targets for each Business Unit of the
              Company, including Covance Corporate (see Appendix 1 for a list of
              units for the 2001 performance year). The performance targets
              shall be based on pre-bonus operating margin, or such other
              financial targets as the Committee shall determine. Corporate HR
              and Finance shall maintain a copy of the objectives.

         (b)  Individual Objectives. The Committee shall approve the objectives
              for the performance year of the CEO and the CEO shall approve the
              objectives of his direct reports, including the Corporate Senior
              Vice Presidents. In the case of the CEO and his executive
              management team, including the Corporate Officers, such
              objectives shall be based on a variety of performance measures,
              such as operating margin, and measures of customer satisfaction
              and operational and people excellence.

         (c)  Percentage Payout. The Committee shall establish performance pool
              percentage payouts setting the percentage payout level, including
              the lowest and highest percentage payout that the pool will pay
              out for actual business unit results against target for each
              category of employee participating in the Plan.

         (d)  Bonus Target Percentages. The Committee shall review bonus target
              percentages for each category of participating employee. The
              target is reflected as a percentage of an employee's base pay
              earned during the performance year in question (the "Employee
              Bonus Percentage"). The product of an employee's base pay earned
              during the performance year and the applicable Employee Bonus
              Percentage is the "Employee Bonus Target Amount").

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<PAGE>

         (e)  Performance Assessment Categories. The CEO shall establish, and
              the Committee shall review, performance assessment categories and
              the impact of such performance assessment on such individuals'
              variable compensation award, if any, under the Plan.

6.       Determination of Business Unit Bonus Pools and Total Bonus Pool: The
         Committee shall certify the Business Units' financial results and
         approve the amount of the total Bonus Pool before the payment of any
         variable compensation under the Plan; provided, however, that for the
         purpose of determining the awards to Individual Contributor employees,
         the CEO shall estimate the Business Unit financial results based on
         performance through November 30 of the performance year in question.
         Payout shall be made to such employees on the basis of such estimates.
         The total Bonus Pool shall be the aggregate of the bonus pools for all
         of the Business Units determined in accordance with Section 5. The
         Committee shall also determine whether the objectives of the CEO have
         been satisfied for the performance year in question. The CEO shall
         assess the performance of his executive management, including the
         Corporate Senior Vice Presidents, compared to their applicable
         objectives for the performance year in question and shall, at the
         Committee's request, review such assessments with the Committee.

7.       Bonus Pool Allocations:

         (a)  Individual Contributor Awards. The variable compensation award for
              Individual Contributor employees shall be determined by
              considering the employee's Business Unit's performance compared to
              its Financial Target, the bonus payout percentage represented by
              such results (the "Business Unit Target Percentage"), and the
              employee's Employee Bonus Percentage.

         (b)  Managers/Supervisors and Key Executive Management. The variable
              compensation award for Manager/Supervisor employees and Key
              Executive/Executive Management employees shall be determined by
              considering the employee's Business Unit Target Percentage, the
              employee's Employee Bonus Percentage and individual performance
              assessment; provided, however, that with respect to employees who
              are not Corporate Vice Presidents of the Company or higher, the
              CEO shall have the authority to adjust, after consultation with
              appropriate members of management, any individual's variable
              compensation award under the Plan; provided, further, however,
              that in no event shall the aggregate amount of the variable
              compensation payments to a Business Unit for a performance year
              exceed such Business Unit's bonus pool.

         (c)  General Manager Discretionary Awards. Each Business Unit General
              Manager and, in the case of Covance Corporate, the CEO, shall have
              the discretion and authority to allocate an additional amount
              equal to up to 5% of the Business Unit bonus pool or such greater
              amount as the Committee shall authorize in any performance year
              (the "Discretionary Bonus") to any plan participant(s) who is not
              a Corporate Vice President or higher based on his/her sole and
              absolute judgment that such individual or entity has made a
              significant contribution to the Company's success or for some
              other important business reason. Such Discretionary Bonus shall
              not be paid until all other amounts payable under the Plan have
              been paid.

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<PAGE>

         (d)  Special Incentive Pool. In the event a Business Unit exceeds its
              performance target, a special incentive pool shall be established
              from which additional incentive awards shall be made to Key
              Executives/Executive Management, provided, however, that members
              of the Global Leadership Council (which shall include the CEO and
              all Corporate Senior Vice Presidents) and recipients of
              performance shares under the Employee Equity Participation Plan
              during the performance year in question shall not be eligible for
              awards from the Special Incentive Pool.

8.       Adjustments:

         (a)  Discretionary Adjustments. The CEO or the Committee, as
              applicable, may in calculating the amount of the total Bonus Pool
              and Bonus Pool for each Business Unit as of the end of the
              performance year in question and assessing whether the financial
              targets and objectives, in each case, have been satisfied, in
              whole or in part, as applicable, or exceeded on a basis consistent
              with circumstances existing when such financial targets and
              objectives, in each case, were established include or exclude, as
              applicable, the effect on the financial targets and objectives
              arising from any acquisition of the stock or assets of any other
              person or entity, the divestiture of all or any of the Company's
              businesses, restructurings, strategic expenditures by Covance
              identified to the Covance Board of Directors as such, force
              majeure events, material litigation, or any other unexpected or
              unforeseen extraordinary event or occurrence during the
              performance year.

         (b)  Prorations. In furtherance of the second proviso of Paragraph
              7(a), the computation of any individual variable compensation
              award to any employee under this Plan (including the CEO and
              executive management) shall be prorated for the aggregate effect
              of individual performance assessments that, without giving effect
              to such proration, would result in variable compensation awards
              that would otherwise exceed the amount of the Bonus Pool for any
              Business Unit for the performance year in question.

9.       Payment Dates: Awards shall be paid no later than December 15 of the
         applicable performance year for the Individual Contributor employees
         and no later than March 15 following the close of the applicable
         performance year for the Manager/Supervisors and Key
         Executive/Executive Management employees. Awards are subject to all
         applicable tax laws and withholding requirements.

10.      Earned Base Pay: For purposes of the Plan, earned base pay is defined
         as the cumulative base salary paid to an employee during the Plan year.
         Because Individual Contributor awards shall be paid out before the end
         of the Plan year (mid-December of the Plan year), earned base pay will
         be defined as cumulative base salary paid up to Mid-November plus an
         estimated amount of earned base pay for the remainder of the Plan year,
         using the formula stated below:

         (Cumulative Earned Salary) + (Per Pay Period Salary times the # of Pay
         Periods Remaining in Plan Year)

11.      Governing Law; Binding Effect: THIS PLAN SHALL BE GOVERNED BY AND
         CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW JERSEY
         (WITHOUT REGARD TO THE CONFLICT OF LAW PROVISIONS THEREOF) AND ALL
         QUESTIONS CONCERNING THE VALIDITY AND CONSTRUCTION THEREOF SHALL BE
         GOVERNED IN ACCORDANCE WITH THE LAWS OF SAID STATE; PROVIDED, HOWEVER,
         THAT ALL MATTERS OF CORPORATE GOVERNANCE AND OTHER CORPORATE MATTERS
         CONCERNING DELAWARE CORPORATION SHALL BE GOVERNED BY THE DELAWARE
         GENERAL CORPORATION LAW.

                                       4
<PAGE>

         Except as otherwise expressly provided herein, this Plan shall be
         binding upon and inure to the benefit of the parties hereto, their
         legal representatives, successors and assigns.

12.      Termination of Employment: Participation in the Plan does not create a
         contract of employment, or grant any employee of the Company the right
         to be retained in the service of, or otherwise employed by, the
         Company. Individuals will not receive a variable compensation award
         under this Plan for the performance year in which their employment
         terminates for any reason or no reason or if they are terminated for
         any reason or no reason prior to the date the variable compensation is
         actually paid for the performance year in question, except where
         otherwise provided in Paragraph 2 hereof. Without limiting the
         foregoing or Paragraph 2 hereof, any individual whose employment is
         terminated for wrongdoing, including, but not limited to, a violation
         of the Company's Business Integrity Plan, including the code of
         conduct, will forfeit all rights to payment under this Plan.

13.      Amendment, Suspension, or Termination: The Board or Committee may, at
         any time, suspend, terminate, waive or amend the Plan (or provisions
         hereof, as applicable), in such respects as the Board or Committee
         deems to be in the best interest of the Company. No amendment will
         adversely affect any right of any grantee, or his successors in
         interest, to keep any variable compensation award actually made
         hereunder before the effective date of the amendment. Plan deferrals,
         if any, in effect at the Plan's termination remain in effect according
         to their original terms.

14.      Effective Date: The Plan will take effect as of January 1, 2001 and
         supersedes in its entirety the Covance Inc. Variable Compensation Plan
         approved on February 24, 2000 (and effective January 1, 2000), the
         Covance Inc. Variable Compensation Plan approved on February 25, 1999
         (and effective January 1, 1999), the Covance Way Covance Inc. Variable
         Compensation Plan, as amended, effective January 1, 1998, the Covance
         Inc. Variable Compensation Plan, as amended, and effective January 1,
         1997, the Covance Inc. General Employee Variable Compensation Plan, as
         amended, and effective January 1, 1997 and the Covance Biotechnology
         Services Inc. Variable Compensation Plan, as amended, and effective
         January 1, 1997.

                                       5
<PAGE>

                                                                      Appendix 1

                COVANCE VARIABLE COMPENSATION PLAN BUSINESS UNITS
                          FOR ACCRUALS AND BONUS POOLS

o    Global Labs

o    Global Phase I Clinics

o    Research Products

o    Global Central Labs & Central Diagnostics

o    ITMS

o    Nexigent

o    Global Clinical Phase II & III

o    Periapproval Services

o    CHEOS

o    Corporate
<PAGE>

                                                                      Appendix 2

                             Effect of Business Unit
                             -----------------------
                        Performance on Individual Payouts
                        ---------------------------------

Employee categories shall be determined by the General Manager of each Business
Unit (except for Key Executive/Executive Management employees who shall be
determined by the Global Leadership Council). Category guidelines and payout
percentages are set forth below.

     Individual Contributor* - generally defined as:

     1.  Clerical, administrative, support-type positions
     2.  For US employees - Non-exempt status
     3.  No supervisory responsibilities
     4.  Generally, employees at a target bonus of five percent or less

<TABLE>
<CAPTION>
     -------------------------------------------------------------------------------------------
         Business Unit Pre-Bonus Operating Margin          Percentage Bonus Payout of Target

     -------------------------------------------------------------------------------------------
<S>                                                                      <C>
            Less than 90% of target                                       80%
     -------------------------------------------------------------------------------------------
            90% to 110% of target                                        100%
     -------------------------------------------------------------------------------------------
            More than 110% of target                                     120%
     -------------------------------------------------------------------------------------------
*Individual performance assessment does not influence payout
</TABLE>

     Manager/Supervisor - generally defined as:

     1.  Professional, managerial and/or technical expertise
     2.  For US employees, Exempt status
     3.  May have supervisory responsibilities
     4.  Employees for whom clear personal objectives are set
     5.  Leadership position within the business unit

<TABLE>
<CAPTION>
     -------------------------------------------------------------------------------------------
         Business Unit Pre-Bonus Operating Margin          Percentage Bonus Payout of Target

     -------------------------------------------------------------------------------------------
<S>                                                                      <C>
            0% to 80% of target                                           75%
     -------------------------------------------------------------------------------------------
            100% of target                                               100%
     -------------------------------------------------------------------------------------------
            120% of target                                               125%**
     -------------------------------------------------------------------------------------------
</TABLE>

     Key Executive/Executive Management - Corporate Officers and select senior
     management employees to be determined annually by the Global Leadership
     Council (GLC).

<TABLE>
<CAPTION>
     -------------------------------------------------------------------------------------------
         Business Unit Pre-Bonus Operating Margin          Percentage Bonus Payout of Target

     -------------------------------------------------------------------------------------------
<S>                                                                      <C>
            0% to 80% of target                                           65%
     -------------------------------------------------------------------------------------------
            100% of target                                               100%
     -------------------------------------------------------------------------------------------
            115% or greater of target                                    125%
     -------------------------------------------------------------------------------------------
     *  Incremental payout rate between minimum and maximum is linear for the
        Manager/Supervisor and Key Executive/Executive Management categories.
     ** The maximum for Senior Managers is exclusive of any payouts under the
        Special Incentive Pool.
</TABLE>
<PAGE>

                                                                      Appendix 3

                 Designated Employee Performance Categories and
                 ----------------------------------------------
                       Performance Attainment Percentages
                       ----------------------------------

<TABLE>
<CAPTION>
     -------------------------------------------------------------------------------------------------

            Rating             Needs             Achieves            Exceeds           Outstanding
                            Improvement        Expectations        Expectations
     -------------------------------------------------------------------------------------------------
         Performance
<S>                           <C>                <C>                <C>                 <C>
         Attainment %         0 - 80%            80 - 110%          110 - 130%          130 - 160%
     -------------------------------------------------------------------------------------------------
</TABLE>

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00030-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00030-of-00352.parquet"}]]