Document:

AGREEMENT BETWEEN EDUCATIONAL VIDEO CONFERENCING,
                 INC. AND YAI NATIONAL INSTITUTE FOR PEOPLE WITH
               DISABILITIES FOR THE LICENSING AND USE OF THE EVCI
                      INTERACTIVE VIDEO/AUDIO/DATA NETWORK

                               W I T N E S S E T H

     AGREEMENT  made this 31st day of August  2000,  between  EDUCATIONAL  VIDEO
CONFERENCING,  INC. (hereinafter "EVCI"), with offices located at 35 East Grassy
Sprain Road, Yonkers, New York 10710, and YAI NATIONAL INSTITUTE FOR PEOPLE WITH
DISABILITIES  (hereinafter "YAI"), with offices located at 460 West 34th Street,
New York, NY 10001.

     WHEREAS,  YAI is an  organization  which provides  services for individuals
with developmental disabilities; and

     WHEREAS,  YAI desires to lease  two-way,  interactive,  video  conferencing
capabilities using broadband, high-speed, IP connectivity; and

     WHEREAS,   EVCI  has  the   ability  to  provide  an   infrastructure   and
communications Network that will allow two-way, interactive,  video conferencing
capabilities  using broadband,  high-speed,  IP connectivity  over  commercially
available telecommunications lines; and

     WHEREAS,  YAI desires to provide five (5) of its facilities  with access to
internal  courses and programs,  professional  development and higher  education
courses and programs for  professional  staff, and other programs and courses as
deemed suitable for YAI community members over such Network; and

     WHEREAS, EVCI has the ability to provide such courses and programs.

     NOW, THEREFORE, it is hereby agreed as follows:

     1.   EVCI agrees that it will  provide an  interactive  video  conferencing
          Network (The  Network)  that will give YAI the ability to  communicate
          both (i)  between its various  sites,  and (ii)  between its sites and
          other providers of educational and training  materials  utilizing EVCI
          and  (iii)  between  its sites and  other  mutually  agreed  upon EVCI
          subscribers,  using video\audio\data.  EVCI shall provide the ATM Line
          Terminator.  YAI shall obtain all  necessary  telecommunication  lines
          from  a  third  party   ("Telecom   Provider").   EVCI  shall   assume
          responsibility  for the interface  between the Network and the Telecom
          Provider  and shall  notify YAI and the  Telecom  Provider of problems
          related to the  communication  lines and  cooperate  with the  Telecom
          Provider  to  correct  such  problems,  but  shall  not  otherwise  be
          responsible  or liable for  failures in the Network to the extent that
          such  failures are  attributable  to failures or faults in the Telecom
          Provider lines.

     2.   EVCI will  deploy a two-way,  interactive,  near 30  frames-per-second
          quality,  interactive,  video conference Network to five (5) YAI sites
          as set forth in Exhibit A,  which is  attached  hereto and made a part
          hereof.  EVCI agrees to extend the Network to additional  YAI sites at
          YAI's  written  request  on terms  the same as those  applying  to the
          initial five (5) sites excluding promotional and sign on incentives.

     3.   YAI will  indicate  location  and  placement  for Network  termination
          equipment, including a basic floor plan for each YAI site, which shall
          also include  location for  termination  equipment and position of all
          site-based  equipment.  YAI shall provide complete contact information
          for each  building,  including  name and  phone  number  of  technical
          contacts, room numbers, phone services, and site project contact.

                                                                               1
<PAGE>

     4.   Network  Management  - EVCI  will  provide  all  related  services  to
          maintain a seamless video communications  Network,  which will include
          line monitoring and failure detection from the EVCI Network to the ATM
          line  terminator.  EVCI shall  replace  or repair  any EVCI  defective
          equipment in accordance with Paragraph 7, below.

     5.   During the term of this  agreement,  EVCI shall make all  updates  and
          enhancements to the existing  software and Network available to YAI at
          no additional charge.

     6.   If the EVCI equipment is lost, stolen or damaged while under the care,
          custody or control of YAI, YAI shall  repair or replace the  equipment
          as soon as  reasonably  practicable,  or  reimburse  EVCI  the cost of
          repairing or replacing  the  equipment  within 30 days of such loss or
          damage.

     7.   EVCI will deploy the required  technical and  non-technical  personnel
          resources  to design and  maintain  the  capability  of the Network as
          described herein, at EVCI's expense.  At the request of YAI, EVCI will
          check the Network in advance of scheduled courses or presentations. In
          the event that YAI becomes aware of technical  problems  affecting the
          operation of the Network, YAI shall promptly notify EVCI, providing an
          accurate  description  of the problem.  Within 30 minutes of receiving
          such a report and description  from YAI, EVCI shall provide YAI with a
          good faith  estimate  of the time  required  to correct the problem in
          order to facilitate any  rescheduling of courses which may be required
          by YAI. EVCI will dispatch  personnel  before the close of business on
          the day after the request  for  service  has been made.  If there is a
          need to  replace  equipment,  EVCI  shall  have the  needed  equipment
          ordered and shipped overnight,  and installed by the close of business
          within two (2) days following receipt of new equipment.

     8.   EVCI will maintain a help desk service to provide customer support and
          problem solving that will  specifically  deal with issues  surrounding
          the EVCI video  conferencing  Network as  required  for all  scheduled
          classes or programs  offered over the Network,  24 hours a day,  seven
          days a week.

     9.   EVCI will  provide,  as needed,  an EVCI  employee to YAI to train YAI
          staff and coordinate the EVCI/YAI programs.

     10.  YAI shall  cooperate  with and assist  EVCI in  marketing  courses and
          programs to YAI  employees  and staff.  EVCI may utilize the equipment
          and  network  at  mutually  convenient  times  at  EVCI's  expense  to
          demonstrate the Network for other potential users.

     11.  YAI shall have the right  during the term of this  agreement to market
          select EVCI products, as mutually determined by the parties. YAI shall
          identify  any  prospective  client to whom it intends  to market  EVCI
          programs and secure  written  authority  from EVCI to proceed prior to
          any  contact  with  said  client.   EVCI  shall  grant  or  deny  such
          authorization within three (3) days of receipt of identification.  Any
          denial of authorization shall be for cause and shall be accompanied by
          an explanation.

     12.  YAI shall be solely  responsible  for all costs for its own marketing,
          advertising,  and promotion regarding EVCI's offerings to YAI approved
          clients. EVCI shall provide master copies of promotional  information,
          and course  schedules to enable YAI to reproduce the  information  for
          marketing and enrollment  purposes  including a co-marketing  brochure
          and publication on the YAI web site if applicable. Except as described
          herein, neither party shall utilize the other's name or any associated
          names, trademarks,  copyrights, etc., without prior written consent of
          the other party, which shall not be unreasonable withheld.

     13.  If a YAI client  desires to purchase  network,  corporate  training or
          educational  content  through YAI and YAI has written  authority  from
          EVCI to pursue such  client,  then EVCI use its best  efforts to enter
          into a contract with such client.

                                                                               2
<PAGE>

     14.  If EVCI enters into a contract  with an  authorized  YAI client,  EVCI
          shall pay to YAI five  percent (5%) of the annual EVCI revenue that is
          generated and collected  through such customers for network,  courses,
          programs  and services  offered by EVCI as a result of YAI's  efforts.
          EVCI shall make such payments, if required,  quarterly on the 15th day
          of the month  following  the end of each  quarter.  YAI shall have the
          right to audit  EVCI's  books and records once every year to ascertain
          EVCI's  compliance  with this  paragraph.  In the even that such audit
          shows an  underpayment  greater than 3%, EVCI shall  reimburse YAI for
          the expense of the audit.  The  obligations  of this  paragraph  shall
          survive the expiration or termination of this agreement.

     15.  Term of Agreement: The basic term of this agreement shall be three (3)
          years,  commencing on the Effective Dates. The Effective Dates of this
          Agreement  shall be the dates that the Network is available for use on
          each of the five (5) sites.  EVCI shall  advise YAI in writing of such
          dates (and  accepted  by YAI as  operational).  This  agreement  shall
          automatically  be renewed  for  further  terms of one (1) year each at
          EVCI's then existing pricing for not for profits unless YAI gives EVCI
          written notice of non-renewal at least thirty (30) days before the end
          of the basic term or any renewal term or unless EVCI ceases  providing
          services of the type covered by this agreement to customers  generally
          and gives YAI written notice of such cessation at least six (6) months
          before  the end of any  renewal  term.  YAI  shall  have the  right to
          terminate  this  agreement  at any  time in the  event  of a  material
          problem  with the Network or a material  breach of this  agreement  by
          EVCI as  follows:  YAI shall  provide  EVCI with  written  notice (the
          "Default  Notice")  specifying  the manner in which EVCI is in default
          under the  agreement.  Upon  receipt of such  notice,  EVCI shall have
          ninety  (90)  days to cure the  default.  YAI shall  give  EVCI  every
          opportunity  to cure the  default  and, to the extent that the default
          does not interfere with  continued use of the Network,  shall continue
          to use the  Network  during the cure  period in the same  manner as it
          used the  Network  prior to the Default  Notice.  If at the end of the
          cure period EVCI has not cured the default,  then this agreement shall
          terminate  immediately  or, if there  are any  scheduled  programs  or
          classes, at the end of such programs or classes,  provided the default
          does not interfere with the provision of such programs or classes.

     16.  Payment:  YAI shall pay to EVCI,  the monthly fee set forth in Exhibit
          A,  commencing the Effective  Dates of this Agreement and on the first
          day of each month  thereafter,  during the term of this Agreement.  If
          the  Effective  Dates are not the first day of a month,  the first and
          last month fee shall be pro-rated accordingly.

     17.  Service  Guarantee  - In the event  that  EVCI is  unable  to  deliver
          scheduled  courses  due to Network  failure  not  attributable  to the
          Telecom  Provider,  then YAI shall have no  obligation to pay EVCI the
          student  station  charges for the  stations  scheduled to receive such
          course(s)  for the  month(s) in which the  failure to deliver  courses
          occurs.

     18.  It is expressly  agreed and  understood  that  neither  party shall be
          liable for incidental, special or consequential damages for any breach
          or violation of this agreement.

     19.  No valid  modification,  amendment,  or  deletion  may be made to this
          Agreement,   except  in  writing,  and  executed  by  the  parties  in
          substantially the same manner as this Agreement.

     20.  Any and all notices  required  hereunder  shall be by Certified  Mail,
          Return Receipt Requested, to each party's address as follows:

          For EVCI                    For YAI

          Dr John McGrath             Barbara Sealey
          President                   Assistant Director
          EVCI                        YAI National Institute for People with
          35 East Grassy Sprain         Disabilities
                                      Road 460 West 34th Street

                                                                               3
<PAGE>

          Yonkers, NY 10710          New York, NY 10001

     21.  If any portion of this agreement  shall be found to be void,  voidable
          or unenforceable, it shall not affect the validity of the remainder of
          the Agreement.

     22.  This  agreement  shall be binding on the  respective  parties'  heirs,
          successors,  and assigns.  EVCI may assign its rights and  obligations
          under this  Agreement  only upon prior written  notice of at least six
          (6)  months.  Upon  receipt of such  notice,  YAI may  terminate  this
          Agreement at any time prior to the effective  date of such  assignment
          by written notice to EVCI.

     23.  The  parties  agree  that  any  disputes  or   disagreements   arising
          hereunder,  or in  connection  herewith,  shall be  settled by binding
          arbitration  before  the  American  Arbitration  Association  at their
          offices  located in New York  City,  New York,  and that any  judgment
          awarded  thereunder  may  be  entered  in  any  court  of  appropriate
          jurisdiction, and will have full force and effect therein.

     24.  This agreement shall be construed in accordance with, and governed by,
          the laws of the State of New York.

     25.  The foregoing  constitutes the entire  agreement  between the parties,
          and  any  other  agreements  or  representations,  whether  verbal  or
          written,  if not contained herein, are void, of no effect, and are not
          binding upon the parties.

     In witness  whereof the parties have  hereunto set their hands and seal the
     date that first appears above.

YAI National Institute for People with Disabilities

By: /S/ BARBARA SEALEY                          Date: 8/31/00
    --------------------------------                  --------------------------
Title:  ASSISTANT DIRECTOR
       -----------------------------

EDUCATIONAL VIDEO CONFERENCING, INC.

By: /S/ JOHN J. MCGRATH, PHD.                   Date: 8/31/00
    --------------------------------                  --------------------------
Title:  PRESIDENT
       -----------------------------

                                                                               4

<PAGE>

                                    EXHIBIT A

                            EVCI INTERACTIVE NETWORK

                           IMPLEMENTATION PROJECT FOR

               YAI NATIONAL INSTITUTE FOR PEOPLE WITH DISABILITIES

                                                                               5

<PAGE>

PROJECT PLAN

EVCI shall place one (1) TEACHER STATION (TS) in the Administrative site and one
(1)  SMALL  ROOM  STATION  (SRS) in each of the five (5)  sites  that  have been
identified  for  inclusion in the Project.  The cost,  benefits and features for
implementation of the Project are identified below:

<TABLE>
<CAPTION>

EVCI INTERACTIVITY NETWORK                                                      MONTHLY CHARGE

<S>                                                                             <C>
1)       SMALL ROOM STATION (SRS)                                               $  316
         Features:   One Dell Pentium III 700 MHz (128 mb ram)
                     Two 21" Dell Monitors
                     One Monitor Splitter
                     One Intel  Proshare  Video  Camera  and  Package  One
                     Keyboard   One   Microphone   One  Mouse   Unit  EVCI
                     Proprietary Software License Package  Teacher/Student
                     Facilitation   Software  Near  30   Frames-per-Second
                     Delivery  Connection Cables Speakers  Microsoft Word,
                     Excel, PowerPoint, Paint
         Benefits:   o Station converts from a Teacher Station to a
                     Student Station for maximum utilization.
                     o Two large monitors permit expanded student
                     access to programs.
                     o Complete live,  interactivity  is available  either
                     through point-to-point or multi-point connectivity.

2)       TEACHER STATION (TS)                                                   $   295
         Features:   One Dell Pentium III 700 MHz (128 mb ram)
                     One 21" Trinitron  Monitor One Intel  Proshare  Video
                     Camera and Package One  Keyboard One  Microphone  One
                     Mouse  Unit One  Document  Scanner  EVCI  Proprietary
                     Software License Package Teacher/Student Facilitation
                     Software   Near   30    Frames-per-Second    Delivery
                     Connection  Cables Speakers  Microsoft  Word,  Excel,
                     PowerPoint, Paint
         Benefits:   o Station converts from a Teacher Station to a
                     Student Station for maximum utilization.
                     o Allows instructor to use video, Internet, and white
                     board as teaching tools.
                     o Complete live,  interactivity  is available  either
                     through point-to-point or multi-point connectivity.
</TABLE>

                                                                               6
<PAGE>

<TABLE>
<CAPTION>

<S>                                                                             <C>
3)       SITE LOCATION SUPPORT                                                  $   234
         Features:   Scheduling Maintenance
                     Installation Assistance
                     24/7 Help Desk Assistance Services
                     Software Updating
                     Line and Equipment Maintenance and Monitoring
                     Professional Training and Support(1)
                     Problem Solving
                     Online Downloads
         Benefits:   o Continuous, round-the-clock access to assistance
                     for equipment and programs
                     o Teacher development in educational technology
                     o Administrative support for programs

         (1) EVCI is  concerned  that  the  best  quality  of  presentation  and
         instruction be offered  through their systems.  Instructors who will be
         teaching  over  EVCI/SRS  systems are  provided  up to two (2),  8-hour
         training  sessions,  for  up  to 15  people,  at  NO  ADDITIONAL  COST.
         Instructors  teaching  over EVCI/TS  systems are provided with one (1),
         four-hour  training session on class design at NO ADDITIONAL COST. This
         will   provide  the  YAI   instructors   the   opportunity   to  create
         video-friendly  content  while  adapting  classroom  content  to  video
         delivery.  Instruction  is  delivered  to each  site  from  top-quality
         professionals from top-ranking instructional institutions. Content will
         include such topics as: Distance  Learning  Techniques,  Technology for
         the Teacher and Creative Curriculum  Development.  Any further training
         will be made available at a small cost.

4)       EVCI HOURLY UTILIZATION    (Estimated)                                 $   1,200(2)
         Features:   Bridging for point-to-point/multipoint
                     connections
                     Reserved time assignments
                     24/7 Network Connectivity
                     Failure detection, replacement and/or repair
                     Network Management
         Benefits:   o Guaranteed access to the Network
                     o Support Safety Net

         (2)  This   figure  is  based  upon   utilization   of  the   equipment
         approximately  10 hours per week on each unit for 40 hours per month (@
         $5 per hour).  YAI will receive a monthly EVCI  Promotional  Rebate for
         usage on Bell Atlantic ATM DS1  installations  made before 10/31/00 (to
         be applied below).

5)       EVCI CONTENT UTILIZATION INCENTIVES
         Features:   Applies to any  EVCI-provider  courses or content  from the
                     2,500+  courses  and/or  250+  degree   programs  that  are
                     currently  available from EVCI and which are delivered over
                     the EVCI  Network to employees of or relatives of employees
                     of  YAI.   Applies   to  any   EVCI-provider   professional
                     development  content  delivered to any YAI site included in
                     the project.
         Benefits:   o A 10% credit based on the cost of tuition for curriculum,
                     and/or  courses and/or  training  and/or  degrees,  will be
                     rebated  back  to  YAI  program   costs  and/or  any  other
                     determined utilization. o Incentive for employees and their
                     family  members to utilize  equipment  to take  courses for
                     their own professional and personal development.
</TABLE>

                                                                               7
<PAGE>

<TABLE>
<CAPTION>

<S>                                                                             <C>
6)       DIGITALIZED VIDEO ARCHIVING AND RETRIEVAL                              $   (3)
         Features:   Allows for in-house training,  EVCI-provider  courses,  and
                     EVCI-provider   professional   development  content  to  be
                     recorded  and  stored  for future  reference.
         Benefits:   o Immediate  access to courses and content not  attended by
                     employees  at  multiple  locations.
                     o  Use  as an  aid  in  training new instructors.
</TABLE>

         (3) Dollar  amount for  digitalized  video  archiving  and retrieval is
         dependent  upon the amount of hours utilized by YAI. Cost for archiving
         and retrieval will be established by EVCI.

                                                                               8

<PAGE>

BELL ATLANTIC TELECONNECTIVITY NETWORK

     A)   ATM DS1  CONNECTIONS
          As a co-partner  with EVCI, Bell Atlantic will design and price an ATM
          DS1-area Network for YAI, which would be dedicated to serving the five
          (5) sites  involved in the Project.  ATM operates on higher data rates
          to  support  voice,  video and data  transmissions  over  fiber  optic
          facilities. ATM provides guaranteed business quality service to ensure
          successful   end-to-end   transmission   for   the   duration   of   a
          teaching/learning/conferencing  session.  The  details of the  Project
          Implementation  Plan  from  Bell  Atlantic,   which  includes  monthly
          services, fees and charges, is available from Bell Atlantic.

     B)   EVCI  PROMOTIONAL  REBATES
          As  indicated  above,  each site  within the  Project  will  receive a
          monthly Rebate of $250.

                                                                               9
<PAGE>

     SUMMARY PROPOSAL FOR YAI - NATIONAL INSTITUTE FOR PEOPLE WITH DISABILITIES

     YAI Administrative Office, New York, NY
     YAI Long Island Services Office, Mineola, NY
     Marine Park Multi-Service Center, Brooklyn, NY
     Bayside Multi-Service
     Center, Bayside, NY
     Tarrytown Multi-Service Center, Tarrytown, NY

<TABLE>
<CAPTION>
<S>                                                                             <C>
I.   MONTHLY PROGRAM COST FOR SRS PER SITE
     1. SRS Unit                                                                      316
     2. Site Location Support                                                         234
     3. Hourly Utilization (assumes 40 hours per month)                               200
     4. EVCI  Tele-connectivity  Rebate Offer  (assumes a Bell  Atlantic ATM DS1
        connection) -                                                                 250

     TOTAL MONTHLY COST PER SITE                                                $     500

II.  MONTHLY PROGRAM COST FOR TS AT ADMINISTRATIVE OFFICE
     1. TS Unit                                                                 $     295
     2. Hourly Utilization (assumes 40 hours per month)                         $     200
                                                                                ---------
     TOTAL MONTHLY COST FOR TS                                                  $     495

III. MONTHLY PROGRAM COST FOR 5 YAI SITES                                       $   2,995

IV.  YEARLY PROGRAM COST FOR 5 YAI SITES                                        $  35,940

        V. Special SIGN-ON  Incentive                                           $   8,985

          As a  special  incentive  for early
          action  clients,  EVCI is  offering
          the FIRST  THREE  MONTHS OF SERVICE
          AT NO CHARGE. The incentive,  which
          expires  8/31/00,  is  designed  to
          allow  EVCI  to work  closely  with
          clients to  establish  the  highest
          quality Network design, service and
          support  in the  start-up  phase of
          the   Project,   while   permitting
          clients   the  full   benefit   and
          enjoyment   of  all   services  and
          programs.

          3 months x $500 per  month = $1,500
          3 months x $495 per  month = $1,485
          ($1,500 x 5 sites) + $1495=8985

VI.  ADJUSTED YEARLY PROGRAM COST FOR YAI AFTER
     SIGN-ON INCENTIVE IS APPLIED (YEAR ONE)                                    $  26,955

</TABLE>

                                                                              10
<PAGE>

VII. DIGITALIZED  VIDEO  ARCHIVING  AND RETRIEVAL
     YAI will be able to record training and educational  courses and content to
     use for future  reference at a fee of $30 per hour for archiving and $8 per
     hour per station for retrieval.

VIII.BREAK-EVEN MODEL (YEAR ONE)
     YAI may be able to offset the cost of the network  through the EVCI Content
     Utilization Incentive.  With this incentive,  ten percent (10%) of the cost
     of EVCI-provider  courses taken by employees is used toward the cost of the
     Network.   Thereby  allowing   employees  to  develop   professionally  and
     personally while benefiting YAI.

     (Assuming students take courses provided by Adelphi University)

     If 67 YAI employees were to each register for four (4) courses with Adelphi
     University at $1300 per course  (estimating  that Adelphi  charges $433 per
     credit for YAI  employees),  they would be spending  $348,400.  Ten percent
     (10%) of the cost of the  courses,  or $34,840  would be  credited to YAI's
     adjusted yearly program cost. Thus,  resulting in zero (0) EVCI cost to YAI
     for the first year.

     IX. Economic  Benefits Model
     YAI may avoid  costs  associated  with  hiring and  increase  its  employee
     retention rate by improved  accessibility to training  courses.  If current
     and new  employees are trained more  efficiently  the  probability  of them
     continuing  to work  for a longer  period  of time at YAI  could  increase.
     Therefore,  with an increase in retention  comes a decrease in advertising,
     hiring, and production loss costs for YAI.

                                                                              11<PAGE>

                                                                  EXHIBIT 10.(v)

                                AMENDMENT NO. 1

                                       TO

                                   AGREEMENT

         AMENDMENT NO. 1 TO EMPLOYMENT AGREEMENT, dated as of July 13, 2000 and
effective retroactively as of May 5, 1999, by and among ENZO BIOCHEM, INC., a
New York corporation with offices at 60 Executive Blvd., Farmindgale, NY 11735
(the "Company") and Elazar Rabbani, an individual residing at 69 Fifth Avenue,
New York, NY 10003 (the "Executive").

                                    RECITALS
                                    --------

         Executive has been President and Chairman of the Board of the Company
since October 15, 1987 and possesses valuable experience, skills and know-how
with respect to all aspects of the Company's business. The parties hereto are
party to an Agreement, dated as of May 4, 1994 (the "Employment Agreement"), and
desire to amend the Employment Agreement as hereinafter set forth. The Company
desires to continue to employ Executive on the terms and conditions set forth in
the Employment Agreement, as amended hereby, and Executive is willing to
continue such employment on such terms and conditions.

         It is therefore hereby agreed by and between the parties as follows:

         1.       Amendments to Employment Agreement.
                  -----------------------------------

                  Section 1.2(a) is hereby amended in its entirety to read as
follows:

                  Except for earlier termination as provided in Section 4
hereof, the Executive's employment under this Agreement (the "Employment Term" )
shall be for an initial term (the "Initial Term") beginning on the date hereof
and ending on May 4, 2002. The Employment Term shall be automatically renewed
for an additional term (an "Additional Term") of two (2) years unless either
party hereto gives written notice to the other at least one hundred eighty (180)
days prior to the expiration of the Initial Term of such party's intention to
terminate the Executive's employment hereunder at the end of such Initial Term.
The Employment Term shall be automatically renewed for an indefinite number of
subsequent Additional Terms of two (2) years unless either party hereto gives
written notice to the other at least one hundred eighty (180) days prior to the
expiration of the Additional Term then in effect of such party's intention to
terminate the Executive's employment hereunder at the end of such Additional
Term.

                  Section 2.1 is hereby amended in its entirety to read as
follows:

                  Base Salary. As compensation for the Executive's employment
hereunder, the Executive shall be entitled to receive a base salary at a rate of
$280,000 per annum payable (and subject to withholding) in accordance with the
Company's normal payroll practices from time to time in effect, to be increased
to $312,000 per annum effective as of January 1, 2000. The base salary may be
increased, but not decreased, from time to time at the discretion of the Board.
(The base salary as increased from time to time being hereinafter referred to as
the "Base Salary.")

<PAGE>

         2.       Reaffirmation of Employment Agreement.
                  --------------------------------------

                  Except as provided herein, this Amendment No. 1 shall not
constitute a waiver or modification of any term, provision or condition of the
Employment Agreement; and all terms, conditions, agreements, provisions,
representations and warranties contained in the Employment Agreement shall
remain in full force and effect.

         3.       Governing Law.
                  --------------

                  This Amendment No. 1 shall be governed by, and construed and
enforced in accordance with, the laws of the State of New York, applicable to
agreements made and to be performed entirely in New York. In addition, each
party hereto irrevocably and unconditionally agrees that any suit, action or
other legal proceeding arising out of this Agreement may be brought only in the
State of New York.

         IN WITNESS WHEREOF, the parties have executed this Amendment No. 1 on
July 13, 2000.

                                        ENZO BIOCHEM, INC.

                                        /s/ Barry Weiner
                                        ----------------------------------------
                                        Name:  Barry Weiner
                                        Title: President

                                        EXECUTIVE:

                                        /s/ Shahram Rabbani
                                        ----------------------------------------
                                        Shahram Rabbani

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