Document:

EX-10.43

 Exhibit 10.43 
 AMENDMENT TO 
 EXECUTIVE EMPLOYMENT AGREEMENT 

This AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT (“Amendment”) is made and entered into as of the 30 day of
DECEMBER, 2008 by and between QUINTILES TRANSNATIONAL CORP., a North Carolina corporation (the “Company”), and JOHN D. RATLIFF (“Executive”). 

WHEREAS, Executive is currently employed under an Executive Employment Agreement with the Company, dated June 14, 2004 (the
“Employment Agreement”), and currently serves as Executive Vice President and Chief Operating Officer, directly reporting to the Chairman and Chief Executive Officer of the Company; 

WHEREAS, the Company and Executive amended the Employment Agreement by a letter to Executive from Michael Mortimer on behalf of
the Company dated September 19, 2006 (the “Letter Agreement”); 
 WHEREAS, the Company and Executive
desire to amend further the Employment Agreement to memorialize new compensation arrangements approved by the Company’s Board of Directors in November 2006 and December 2007 and to evidence compliance with Section 409A of the Internal
Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”); and 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth below and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the
Company and Executive agree that the Employment Agreement, as amended by the Letter Agreement (the “Amended Employment Agreement”) shall be further amended as follows: 

1. COMPENSATION. Section 3, COMPENSATION, of the Amended Employment Agreement is deleted in its entirety and the
following Section is inserted in lieu thereof: 
 3. COMPENSATION. 

3.1 Base Salary. Executive’s annual salary for all services rendered shall be Five Hundred
Fifty Thousand and No/100 Dollars ($550,000.00) (less any applicable taxes and withholdings), payable in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. Executive’s salary may be
reviewed and is subject to adjustment in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. 
 3.2 Performance Incentive Plan. Executive may participate on a basis commensurate with his position as a senior executive 

 
officer, as determined by the Company, in the Quintiles Performance Incentive Plan. For the year 2008, Executive is eligible to participate at a target level of one hundred percent (100%) of
his annual base salary. This target level may be increased or decreased in subsequent years at the discretion of the Company. Beginning with the year 2008, the Performance Incentive Plan cap shall increase to two hundred percent (200%) of
target, based on Company and personal performance. Any Bonus paid to Executive shall be less applicable withholdings and shall be distributed pursuant to policies as determined by the Company, but in no event later than March 15 of the calendar
year following the calendar year in which such Bonus was earned. 
 3.3 Annual Executive
Allowance. Each year during the term of this Amended Employment Agreement, Executive shall be entitled to receive payment of Thirty Thousand and No/100 Dollars ($30,000.00), less any applicable taxes and withholdings, as an Executive
Allowance. The Executive Allowance shall be paid in substantially equal installment payments in accordance with the Company’s normal payroll practices. This Executive Allowance is intended to be used for miscellaneous expenses and allowances
previously provided by the Company such as car allowance, tax return preparation fees, financial planning fees, legal fees, and the micropurchase plan. 
 3.4 Other Benefits. Executive may participate in all medical, dental and disability insurance, 401(k), pension, personal leave, and other benefit plans and programs provided by the Company
to other employees at Executive’s level except that Executive may not receive severance payments other than as specified in this Amended Employment Agreement; provided, however, that Executive’s participation in such benefit plans and
programs is subject to the applicable terms, conditions and eligibility requirements of these plans and programs, some of which are in the plan administrator’s discretion, as they may exist from time to time. 

3.5 Business Expenses. Executive shall be reimbursed for reasonable and necessary expenses actually
incurred by him in performing services under this Amended Employment Agreement in accordance with and subject to the terms and conditions of the applicable Company reimbursement policies, procedures, and practices as they may exist from time to
time. Expenses covered by this provision include, but are not limited to, travel, entertainment, professional dues and subscriptions, and dues, fees, and expenses associated with membership in various professional and business and civic associations
in which Executive’s participation is in the Company’s best interest. All such reimbursements shall be made no later than March 15 of the calendar year following the calendar year in which the expenses were incurred. 

  
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 3.6 Modifications or Revisions of Benefit Plans and Programs.
Nothing in this Amended Employment Agreement shall require the Company to create, continue, or refrain from amending, modifying, revising, or revoking any of the plans, programs, or benefits set forth in Sections 3.2 through 3.5. Any amendments,
modifications, revisions, and revocations of these plans, programs, and benefits shall apply to Executive. 

3.7 Offset for Disability Payments. If, at any time, during which Executive is receiving salary or
post-termination payments from the Company, he receives payments on account of mental or physical disability from any Company-provided plan, then the Company, at its discretion, may reduce his salary or post-termination payments by the amount of
such disability payments.” 
 2. TERM OF EMPLOYMENT. Section 4, TERM OF EMPLOYMENT, of the Amended Employment
Agreement shall be amended as follows: 
 Executive’s Right to Terminate for a Breach by the
Company. Section 4.4 of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu thereof: 
 “4.4 Executive may terminate employment in the event the Company materially breaches this Agreement if: (i) Executive provides the Company with written notice of the material breach of
this Agreement within ninety (90) days of the initial actions or inactions of the Company giving rise to such breach; (ii) the Company has not cured such breach within ninety (90) days of such notice (“Cure Period”); and
(iii) if the Company fails to cure such breach, Executive terminates employment under this Agreement within ninety (90) days of the expiration of the Cure Period.” 

  
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 3. COMPENSATION AND BENEFITS UPON TERMINATION. Section 5, COMPENSATION
AND BENEFITS UPON TERMINATION, of the Amended Employment Agreement shall be amended as follows: 
  

	 	(a)	Termination by the Company Without Cause or for Non-Renewal or by the Executive for a Material Breach. Section 5.2 (iii) of the Amended
Employment Agreement is deleted in its entirety and the following Section is inserted in lieu thereof: 

 “(iii) subject to Executive’s compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.5, an amount equal to the sum of 1.55 times his then current monthly base salary (less
applicable withholdings) multiplied by thirty six (36), plus an amount equal to three times his Annual Executive Allowance under Section 3.3, such sum to be payable in lump sum (less applicable withholdings) within ten (10) calendar days
following the effective date of the general release required by Section 5.5, but not later than ninety (90) days following termination.” 
  

	 	(b)	Benefit Continuation. Section 5.3 of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu
thereof: 

 “5.3 In the event Executive is receiving payments under Section 5.2 of the
Amended Employment Agreement, and subject to Executive’s compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.5, Executive shall be entitled to a lump sum payment equal to thirty six (36) multiplied by the
Company’s monthly cost for providing the type of medical, dental, vision, long term disability and term life insurance coverage, as applicable, in effect for Executive (e.g., family coverage vs. employee-only coverage) at the time of his
termination, payable in a one-time lump sum payment, less any applicable tax withholdings, within ten (10) calendar days following the effective date of the general release required by Section 5.5, but not later than ninety (90) days
following termination from employment. Any payment under this section that is includible in Executive’s gross income shall be increased by an additional amount equal to the Federal income tax applicable to such payment determined by applying
the highest marginal Federal tax rate in effect at the payment date. Executive shall bear full responsibility for applying for COBRA continuation coverage and for obtaining coverage under any other insurance policy following termination of
employment, and nothing herein shall constitute a guarantee of COBRA continuation coverage or benefits or a guarantee of eligibility for health, dental, long term disability or term life insurance coverage.” 

 

	 	(c)	Release of Claims as a Condition of Payment from the Company. Section 5.5 of the Amended Employment Agreement is deleted in its entirety and the
following Section is inserted in lieu thereof: 

  
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 “5.5 Notwithstanding any provision of this Amended Employment
Agreement to the contrary, the Company’s obligation to provide the payments and benefits under Sections 5.2 and 5.3 of this Amended Employment Agreement is conditioned upon Executive’s execution of an enforceable release of claims and his
compliance with Sections 6, 7, 8 and 9 of this Amended Employment Agreement. If Executive chooses not to execute such a release or fails to comply with these sections, then the Company’s obligation to compensate him ceases on the effective
termination date except as to amounts due at the time and any amount subsequently due pursuant to the plan described in Section 3.2. The release of claims shall be provided to Executive within thirty (30) days of his separation from
service and Executive must execute it within the time period specified in the release (which shall not be longer than forty five (45) days from the date of receipt). Such release shall not be effective until any applicable revocation period has
expired.” 
 4. SECTION 409A OF THE INTERNAL REVENUE CODE. The following provisions shall be added to the end
of the Amended Employment Agreement as Section 19: 
 “19 Section 409A of the Internal
Revenue Code 
 19.1 Parties’ Intent. The parties intend that the provisions of this Amended
Employment Agreement comply with the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”) and all provisions of this Amended Employment Agreement shall be construed
in a manner consistent with the requirements for avoiding taxes or penalties under Section 409A. If any provision of this Amended Employment Agreement (or of any award of compensation, including equity compensation or benefits) would cause
Executive to incur any additional tax or interest under Section 409A, the Company shall, upon the specific request of Executive, use its reasonable business efforts to in good faith reform such provision to comply with Code Section 409A;
provided, that to the maximum extent practicable, the original intent and economic benefit to Executive and the Company of the applicable provision shall be maintained, and the Company shall have no obligation to make any changes that could
create any additional economic cost or loss of benefit to the Company. The Company shall timely use its reasonable business efforts to amend any plan or program in which Executive participates to bring it in compliance with Section 409A.
Notwithstanding the foregoing, the Company shall have no liability with regard to any failure to comply with Section 409A so long as it has acted in good faith with regard to compliance therewith. 

19.2 Separation from Service. A termination of employment shall not be deemed to have occurred for purposes of any
provision of this Amended Employment Agreement providing for the payment of any amounts or benefits upon or following a termination of employment unless such termination also constitutes a “Separation from Service” within the meaning of
Section 409A and, 

  
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for purposes of any such provision of this Amended Employment Agreement, references to a “termination,” “termination of employment,” “separation from service” or
like terms shall mean Separation from Service. 
 19.3 Separate Payments. Each installment payment required
under this Amended Employment Agreement shall be considered a separate payment for purposes of Section 409A. 
 19.4
Delayed Distribution to Key Employees. If the Company determines in accordance with Sections 409A and 416(i) of the Code and the regulations promulgated thereunder, in the Company’s sole discretion, that Executive is a Key
Employee of the Company on the date his/her employment with the Company terminates and that a delay in benefits provided under this Amended Employment Agreement is necessary to comply with Code Section 409A(A)(2)(B)(i), then any severance
payments and any continuation of benefits or reimbursement of benefit costs provided by this Amended Employment Agreement, and not otherwise exempt from Section 409A, shall be delayed for a period of six (6) months following the date of
termination of Executive’s employment (the “409A Delay Period”). In such event, any severance payments and the cost of any continuation of benefits provided under this Amended Employment Agreement that would otherwise be due and
payable to Executive during the 409A Delay Period shall be paid to Executive in a lump sum cash amount in the month following the end of the 409A Delay Period. For purposes of this Amended Employment Agreement, “Key Employee” shall mean an
employee who, on an Identification Date (“Identification Date” shall mean each December 31) is a key employee as defined in Section 416(i) of the Code without regard to paragraph (5) thereof. If Executive is identified as a
Key Employee on an Identification Date, then Executive shall be considered a Key Employee for purposes of this Amended Employment Agreement during the period beginning on the first April 1 following the Identification Date and ending on the
following March 31.” 
 5. COUNTERPARTS. This Amendment may be executed in counterparts, each of which
shall be an original, with the same effect as if the signatures affixed thereto were upon the same instrument. 
 6.
DEFINITIONS. All terms used in this Amendment shall have the same definitions as used in the Amended Employment Agreement, unless otherwise provided herein. All references to “Amended Employment Agreement” shall include all
modifications made by this Amendment, unless provided otherwise. 
 7. EFFECT OF AMENDMENT. Except as amended
hereby, the Amended Employment Agreement shall remain in full force and effect and is hereby ratified and confirmed by the Company and Executive in all respects. 

  
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 IN WITNESS WHEREOF, this Amendment has been duly executed as of the day and year set forth
above. 
  

					
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 /s/ Michael Mortimer

		 	Name:	 	Michael Mortimer
		 	Title:	 	Executive Vice President and
Chief Administrative Officer
	
	EXECUTIVE:
	
	 /s/ John D. Ratliff

	John D. Ratliff

  
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 SUPPLEMENT TO 
 EXECUTIVE EMPLOYMENT AGREEMENT 
 This supplements that certain Executive
Employment Agreement by and between QUINTILES TRANSNATIONAL CORP. and JOHN D. RATLIFF dated June 14, 2004, as amended (the “Employment Agreement”). Pursuant to this supplement, if John D. Ratliff retires, elects not to renew
his Employment Agreement or otherwise voluntarily departs from service to Quintiles, he shall be entitled to the same benefits as the benefits owed to Mr. Ratliff had he been terminated without “Cause,” as described in the Employment
Agreement, including cash severance payments, insurance benefits and executive allowance benefits (each as described more fully in Mr. Ratliff’s Employment Agreement), which shall be calculated and payable upon the same terms and subject to the
same conditions (as set forth in his Employment Agreement) following the date his employment relationship with Quintiles ends. 
  

			
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 
		
	Name:	 	 
		
	Title:	 	 
		
	Date:	 	 
	
	EXECUTIVE:
	
	 
	            John D. Ratliff
		
	Date:EX-10.1

 Exhibit 10.1 
 ALEXZA PHARMACEUTICALS, INC. 

2013 CASH BONUS PLAN 
 1. GENERAL. 
 (a) Eligible Bonus Award Recipients. The
persons eligible to receive Bonus Awards are all Alexza employees, including Officers, Executive Directors, Directors, Managers and Individual Contributors. 
 (b) Form of Bonus Awards. All Bonus Awards under the Bonus Plan will be paid in cash. 
 (c) Purpose. The Company, by means of the Bonus Plan, seeks to secure and retain the services of the group of persons eligible to receive Bonus Awards as set forth in Section 1(a) and to
provide incentives for such persons to exert maximum efforts for the success of the Company. 
 2. DEFINITIONS.

 (a) “Base Salary” means a Participant’s annual base compensation, as determined on the
applicable Bonus Determination Date. 
 (b) “Board” means the Board of Directors of the Company.

 (c) “Bonus Award” means, with respect to each Participant, the award in the amount determined
by the Committee, in its sole discretion, on any Bonus Determination Date. 
 (d) “Bonus Determination
Date” means the date upon which the Committee, in its sole discretion, determines the actual Bonus Award earned by each Participant. 
 (e) “Bonus Plan” means this Alexza Pharmaceuticals, Inc. 2013 Cash Bonus Plan. 
 (f) “Committee” means the Compensation Committee of the Board or such other committee of the Board (including, without limitation, the full Board) to which the Board has
delegated power to administer the Bonus Plan. 
 (g) “Company” means Alexza Pharmaceuticals, Inc.

 (h) “Continuous Service” means that the Participant’s service with the Company, whether
as an Officer, Executive Director, Director, Manager or Individual Contributor is not interrupted or terminated. A change in the capacity in which the Participant renders service to the Company as an Officer, Executive Director, Director, Manager or
Individual Contributor, provided that there is no interruption or termination of the Participant’s service with the Company, shall not terminate a Participant’s Continuous Service. To the extent permitted by law, the Committee or the chief
executive officer of the Company, in that party’s sole discretion, may determine whether Continuous Service shall be considered interrupted in the case of any leave of absence approved by that party, including sick leave, military leave or any
other personal leave. 

 (i) “Corporate Goal” means any of the Corporate Goals set
forth on Exhibit A. 
 (j) “Director” means a person who is at the management level of
Associate Director through Director level, or at the technical level of Sr. Scientist II or Sr. Research Fellow, or Principal Engineer or Sr. Fellow Engineer. 
 (k) “Executive Director” means a person who is at the management level of Executive Director. 
 (l) “Individual Contributor” means all other employees not in the Manager, Director, Executive Director, Officer or CEO role. 

(m) “Manager” means a person who is at the management level of Supervisor through Sr. Manager, or at the
technical level of Scientist I through Sr. Scientist I level, or Sr. Engineer I through Sr. Staff Engineer level. 
 (n)
“Multiplication Factor” means a factor set in accordance with Section 5 hereof, which may increase or decrease an individual’s Bonus Award based upon such individual’s performance. 

(o) “Officer” means a person designated as such by the Board. 

(p) “Participant” means an eligible Officer, Executive Director, Director, Manager or Individual
Contributor selected by the Committee, in its sole discretion, to participate in the Bonus Plan. 
 (q)
“Performance Period” means January 1, 2013 through December 31, 2013. 
 (r)
“Target Bonus Award” means the target award payable under the Bonus Plan to a Participant, as determined by the Committee. Each Participant’s Target Bonus Award equals the product of such Participant’s
(i) Base Salary, and (ii) Target Bonus Percentage. For example, an Officer with a Base Salary is $200,000, whose Target Bonus Percentage is 40% would have his or her Bonus Award calculated by reference to a Target Bonus Award of $80,000
($200,000 x 40%). 
  

			
	 (s) “Target Bonus Percentage” means:
	 	60% for the chief executive officer;
		 	40% for Officers;
		 	25% for Executive Directors;
		 	20% for Directors;
		 	15% for Managers; and
		 	10% for Individual Contributors

 3. Plan Administration. 
 (a) The Committee shall be responsible for the general administration and interpretation of the Bonus Plan and for carrying out its provisions. The Committee may delegate specific administrative
tasks to Company Employees or others as appropriate for proper administration of the Bonus Plan. The Committee shall have such powers as may be necessary to discharge its duties hereunder, including, but not by way of limitation, the following
powers and duties, but subject to the terms of the Bonus Plan: 

 (i) authority to determine eligibility and the amount, manner and time of payment of
any Bonus Awards hereunder; 
 (ii) authority to construe and interpret the terms of the Bonus Plan; 

(iii) authority to adopt rules, regulations and bylaws and to take such actions as it deems necessary or desirable for the proper
administration of the Bonus Plan. 
 (b) Any rule or decision by the Committee that is not inconsistent with the
provisions of the Bonus Plan shall be conclusive and binding on all persons, and shall be given the maximum deference permitted by law. 
 4.
Earning of Bonus Award. Participation in the Bonus Plan is at the discretion of the Committee. If an Officer, Executive Director, Director, Manager or Individual Contributor is hired after the beginning of the Performance Period, the Committee
shall have the discretion to determine whether such individual should be eligible to participate in the Bonus Plan and whether such participation, if any, should be prorated. A Participant must be in Continuous Service, and must meet the minimum
standard of performance for their position in the Company on the end date of the Performance Period to earn any Bonus Award under this Bonus Plan; if the Participant’s Continuous Service terminates before the end date of the Performance Period,
the Participant will not be eligible to receive a Bonus Award, or any portion of a Bonus Award, except as provided in an applicable severance plan or in an individual employment or retention agreement with such Participant. 

5. Determination of Bonus Awards; Timing of Payment. On or after December 31, 2013, the Committee shall determine Bonus Awards based on the
Target Bonus Awards, the overall achievement of the Corporate Goals and individual performance. To earn a Bonus award, an individual must be in good standing and not on a performance improvement plan on the end date of the Performance Period, and
the Company must achieve at least 70% of the Corporate Goals, as determined by the Committee. For eligible individuals, the individual performance Multiplication Factor will not increase or decrease any Participant’s Bonus Award by more than
30%. The Committee’s determination of the achievement of the Corporate Goals will account for the determination of 80% of each Bonus Award, and the remaining 20% of such Bonus Award is subject to the sole discretion of the Committee. The chief
executive officer will determine the Multiplication Factor for each individual other than the chief executive officer. The Board will determine the Multiplication Factor for the chief executive officer. The Company shall distribute amounts payable
to Participants within 60 days following the Bonus Determination Date in respect of these Bonus Awards. 
 6. Amendment and Termination of
the Bonus Plan. The Committee may amend, modify, suspend or terminate the Bonus Plan, in whole or in part, at any time, including adopting amendments deemed necessary or desirable to correct any defect or to supply omitted data or to
reconcile any inconsistency in the Bonus Plan or in any Bonus Award granted hereunder. At no time before the actual payment of Bonus Awards to Participants under the Bonus Plan shall any Participant accrue any vested interest or right whatsoever
under the Bonus Plan. 

 7. Withholding. Each Bonus Award shall be reduced by the sums required to satisfy the federal, state,
local and foreign tax withholding obligations of the Company, if any, which arise in connection with the payment of such Bonus Award. 
 8.
Unfunded Plan. The Bonus Plan is unfunded and nothing in the Bonus Plan shall be construed to create a trust or to establish or evidence any Participant’s claim of any right to payment of a Bonus Award other than as an unsecured general
creditor with respect to any payment to which he or she may be entitled. Each Bonus Award under the Bonus Plan shall be paid solely from the general assets of the Company. 
 9. No Guarantee of Employment. The Bonus Plan is intended to provide a financial incentive to Participants and is not intended to confer any rights to continued employment upon Participants whose
employment will remain at-will and subject to termination by either the Company or Participant at any time, with or without cause or notice. 

10. Recovery. Any amounts paid hereunder shall be subject to recoupment in accordance with The Dodd–Frank Wall Street Reform and Consumer
Protection Act and any implementing regulations thereunder, any clawback policy adopted by the Company or as is otherwise required by applicable law. 

 EXHIBIT A 

2013 PERFORMANCE GOALS 
 Corporate Goal 1: U.S. ADASUVE commercialization 

	 	•	 	 Production scale-up, with 50,000 units at the wholesaler 

	 	•	 	 Execute U.S. post-approval regulatory commitments 

	 	•	 	 Complete U.S. pre-commercialization for product launch 

 Corporate Goal 2: EU ADASUVE commercialization 

	 	•	 	 Gain ADASUVE EMA approval 

	 	•	 	 Support EU commercialization for product launch with Ferrer 

	 	•	 	 Production scale-up, with 6-month lead time from Ferrer purchase orders 

	 	•	 	 Execute EU post-approval regulatory commitments 

 Corporate Goal 3: Commercial manufacturing follow-on projects 

	 	•	 	 Maintain stability and overall facility compliance program 

	 	•	 	 Lower housing assembly - complete qualification / gain regulatory approval 

	 	•	 	 Application-specific integrated circuit project - complete design cycle testing (“DCT”), supplier qualification, submit regulatory filing

 Corporate Goal 4: Move AZ-002 in clinical development 

	 	•	 	 Complete DCT, design verification testing and clinical trial materials 

	 	•	 	 Initiate Phase 2a Proof-of-Concept clinical study 

	 	•	 	 Re-establish toxicology test article manufacturing 

 Corporate Goal 5: Conduct new product planning assessment for new pipeline candidates 

Corporate Goal 6: Execute and maintain commercial partnership agreements 

	 	•	 	 Maintain Ferrer partnership 

	 	•	 	 Finalize US commercial strategy 

	 	•	 	 Close additional non-US distributorship deals 

 Corporate Goal 7: Maintain public company reporting and administration 

	 	•	 	 Complete required SEC filings and maintain SOX compliance 

	 	•	 	 Maintain IP filings 

	 	•	 	 Update employee systems, compensation philosophies and other compliance and administration items.

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