Document:

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                                                                   EXHIBIT 10.11

                                                                  Execution Copy
                                                                  --------------

                               LICENSE AGREEMENT
                               -----------------

     This License Agreement (this "Agreement") is entered into as of November
                                   ---------
20, 2001 (the "Effective Date"), by and between American BioScience, Inc., a
               --------------
California corporation ("ABI") and American Pharmaceutical Partners, Inc., a
California corporation ("APP").
                         ---

                                    RECITALS
                                    --------

     A.  ABI has developed and owns the rights to the Product, as defined in
Section 1.21 of this Agreement.
------------

     B.  APP is in the business of manufacturing, marketing and distributing
pharmaceutical Products in the United States and elsewhere in the world, and has
special expertise in oncolytics.

     C.  The Parties desire to enter into an agreement for APP to market,
distribute and sell the Product under a license from ABI.

                                   AGREEMENT
                                   ---------

     In consideration of the premises, the mutual covenants contained herein,
and other good and valuable consideration, the receipt and sufficiency of which
is acknowledged, the Parties agree as follows:

     1. Definitions. As used in this Agreement (in addition to other definitions
        -----------
set forth in this Agreement), the following definitions shall apply:

        1.1 "ABI Parties means ABI, its Affiliates, permitted assignees and any
             -----------
party (if any) licensed or approved by ABI to use, market, distribute, import,
export, sell or offer to sell the Product with the exception of the APP Parties.

        1.2 "Action" means any actual or threatened claim, suit, arbitration,
             ------
hearing, inquiry, proceeding, complaint, charge or investigation by or before
any court, government, governmental entity or arbitrator.

        1.3 "Affiliate" means any entity controlling, controlled by or under the
             ---------
common control of APP or ABI, as the case may be. Such entity will be considered
an Affiliate only for the time during which such control exists. For the purpose
of this Agreement, "control" means having, directly or indirectly, the power to
direct or cause the direction of management and policies of such entity. FOR
PURPOSES OF THIS AGREEMENT, APP WILL NOT BE CONSIDERED AN AFFILIATE OF ABI, AND
ABI WILL NOT BE CONSIDERED AN AFFILIATE OF APP.

        1.4 "APP Parties" or "APP Party" means any of APP, its Affiliates and
             -----------
its permitted sublicensees and assignees.

        1.5 "Chargeable Price" means, with respect to Product manufactured by
             ----------------
APP, the Standard Costs per unit of Product, and with respect to Product not
manufactured by APP, the

[***] Omitted pursuant to a confidential treatment request. The material has
      been filed separately with the Securities and Exchange Commission.

<PAGE>

price APP pays for the Product from ABI's designated manufacturer(s) plus the
reasonable costs of quality control and other activities performed by APP that
would be included in Standard Costs if APP were the manufacturer.

        1.6 "Chemical Ingredients" means paclitaxel and albumin.
             --------------------

        1.7 "Competitor" means a business entity that markets and sells a
             ----------
pharmaceutical Product that includes taxanes as an active pharmaceutical
ingredient.

        1.8 "Damages" means any and all losses, liabilities, obligations, costs,
             -------
expenses, damages or judgments of any kind or nature whatsoever including
reasonable attorneys', accountants' and experts' fees, disbursements of counsel
and other costs and expenses incurred in pursuing or defending claims under this
Agreement.

        1.9 "FDA" means the United States Food and Drug Administration or any
             ---
other successor agency whose approval is necessary to market the Product in the
United States and any comparable agency in other countries in the Territory
where ABI intends to obtain regulatory approval.

        1.10 "GAAP" means generally accepted accounting principles as in effect
              ----
in the United States applied on a basis consistent with past practice.

        1.11 "Gross Profits (or Losses)" means Net Sales less: (A) Chargeable
              -------------------------
Price; (B) any fees, costs and expenses incurred by APP in connection with
obtaining and maintaining Regulatory Approval for the Product including, without
limitation, those paid pursuant to Section 13.2; and (C) user fees. Any moneys
                                   ------------
paid to ABI under Sections 8, 9, 10 and 11 of this Agreement will not be
                  -------- -  -  --     --
included in the calculation of Gross Profits (or Losses).

        1.12 "Gross Sales Net of Chargebacks" means gross invoiced sales of the
              ------------------------------
Product by APP to its customers (or in the case of sales to an Affiliate of APP,
the first sale to a non-affiliated customer) less chargebacks.

        1.13 "IPO" means the closing of the first sale by APP of shares of its
              ---
common stock, par value $0.001 per share, for an aggregate offering price of a
minimum of $50 million in an underwritten public offering registered under the
Securities Act of 1933, as amended.

        1.14 "Legal Requirement" means any statute, law, ordinance, rule,
              -----------------
regulation, permit, order, writ, judgment, injunction, decree or award issued,
enacted or made by any governmental entity or any arbitrator.

        1.15 "Manufacturing Agreement" means that certain manufacturing
              -----------------------
agreement entered into between ABI and APP dated the same date as this
Agreement.

        1.16 "Manufacturing Recall" means a Recall arising from or relating to
              --------------------
the Product that, when manufactured by APP, was adulterated, contaminated or was
otherwise caused by APP's failure to comply with the Manufacturing Agreement or
the Specifications as defined in the Manufacturing Agreement.

<PAGE>

        1.17 "NDA" means one or more of the New Drug Applications that ABI files
              ---
for the Product with the FDA, including any supplements or amendments and
510(k)s, and any foreign equivalents in Canada or Mexico.

        1.18 "Net Sales" means Gross Sales Net of Chargebacks less, with respect
              ---------
to sales of Product: (A) freight and insurance charges actually paid; (B)
discounts, credits or allowances, if any, given or made because of price
adjustments; (C) actual replacements, returns or rebates (including but not
limited to group purchasing organization fees and rebates and governmental
rebates); (D) reasonable selling and marketing expenses (including pre-launch
expenses and sales force costs); (E) sales, excise and value added taxes if paid
by APP and (F) general and administrative costs incurred with respect to the
Product during a calendar year [***]. The amount of the Net Sales for any period
will be determined in accordance with GAAP on the basis of sales recorded in the
ordinary course on the books of the relevant APP Parties during such period,
less the deductions provided for in this Section 1.18.
                                         ------------

        1.19 "Parties" means APP and ABI ("Party" meaning one of the Parties).
              -------

        1.20 "Person" means any natural person, corporation, trust, association,
              ------
company, partnership, joint venture, governmental entity or other entity.

        1.21 "Product" means ABI-007, a cremaphor-free, nanoparticle paclitaxel
              -------
formulation [***].

        1.22 "Product Liability Claim" means any Action by a third party and any
              -----------------------
appeal from any Action asserted by a third party with respect to the Product
alleging product liability, product defect, design, manufacturing, packaging or
labeling defect, failure to warn, or any similar action relating to the
formulation, manufacture, use or safety of the Product.

        1.23 "Proprietary Information" means all information relating to the
              -----------------------
Product, the properties, composition or structure of the Product or the
manufacture or processing of the Product or the machines used to manufacture or
process the Product or to a Party's business (including, without limitation,
reagents, computer programs, algorithms, names and expertise of employees and
consultants, know-how, formulas, processes, ideas, inventions, whether
patentable or not, schematics and other technical, business, financial, customer
and Product development plans, forecasts, strategies and information), whether
previously, currently or subsequently disclosed to the other Party. ABI's
Proprietary Information shall include ABI Owned Developments and ABI
Developments. APP's Proprietary Information shall include APP Owned
Developments.

        1.24 "Proprietary Rights" means any and all patent rights, copyrights,
              ------------------
mask work rights, trade secret rights and all other intellectual and industrial
property rights.

        1.25 "Regulatory Approval" means the procurement of any registration,
              -------------------
permit and approval required by applicable government authorities for the
manufacture, importation, marketing, sale or distribution of the Product.

        1.26 "Standard Costs" means direct and indirect costs, including without
              --------------
limitation the materials, components, raw materials, direct labor and overhead,
attributable to

<PAGE>

production, manufacturing, processing, quality control and packaging by APP of
the Product, and shall be fixed year-to-year as set forth hereafter. Except for
the purposes of determining Actual Costs in accordance with Section 10.6(B),
                                                            ---------------
Standard Costs will not include costs incurred in connection with Bad Batches
(as hereafter defined) of the Product. In addition, Standard Costs will not
include general and administrative costs. The Standard Costs will be updated at
the end of each calendar year for the purpose of determining Chargeable Price
for the succeeding year. Except as otherwise contemplated by this definition or
agreed by the Parties, Standard Costs will be determined in accordance with GAAP
and standard costing principles as currently practiced by APP.

        1.27 "Technology" means any and all ideas, techniques, inventions,
              ----------
methods, data, information, formulae, processes, trade secrets, intellectual
property, know-how, and test results, whether patentable or not, and whether or
not reduced to practice, including Proprietary Rights, owned, controlled or
otherwise in possession of or used by ABI as of the date of this Agreement, or
during the term of this Agreement and necessary or useful to make, have made,
develop, have developed, use, import, market, offer for sale or sell the
Product.

        1.28 "Territory" means North America.
              ---------

     2. License Grant.
        -------------

     Subject to the terms and conditions set forth in this Agreement:

        2.1 ABI grants to APP a license to and under the Technology to use,
market, distribute, import, export, sell and offer to sell the Product in the
Territory subject to Section 9. Any modification or improvement made by or for
                     ---------
ABI to the Technology during the term of this Agreement must be promptly
disclosed to APP and included in this license without additional charge to APP,
except as provided in Section 9. Subject to any modification under Section 9,
                      ---------                                    ---------
APP's license is exclusive solely within the Territory, even as against ABI. APP
will have the right to grant sublicenses to third parties as provided in Section
                                                                         -------
2.2.
---

        2.2 APP's right to sublicense will be in accordance with the terms of
the license granted to APP under this Agreement. Any sublicense and the relevant
sublicense agreement will be subject to ABI's review and prior written approval,
which approval shall not be unreasonably withheld or delayed. Despite the
foregoing, in no event will ABI be obligated to consent to the sublicensing of
this Agreement to a Competitor. Even if APP sublicenses the license granted
under this Agreement, APP will remain responsible to ABI for the performance of
its obligations under this Agreement and for any breach of the obligations under
this Agreement whether or not the breach is caused by APP or any sublicensee.

        2.3 APP may purchase the Product only from manufacturer(s) designated in
writing by ABI, which manufacturer(s) shall initially be APP under the
Manufacturing Agreement. ABI hereby designates APP as a manufacturer from which
APP may purchase the Product, for as long as the Manufacturing Agreement is in
effect.

        2.4 If ABI terminates APP's right to manufacture Product under the
Manufacturing Agreement for any reason other than under Section 12.2 or 12.4 of
                                                        --------------------
said Agreement, ABI shall arrange for adequate supply of Product to APP for sale
in the Territory for

<PAGE>

the duration of APP's license under this Agreement at a price not in excess of
the Chargeable Price applicable to APP manufactured Product in effect at the
time of such termination, as such price would be adjusted from time to time if
APP had been the manufacturer. If ABI terminates the Manufacturing Agreement
under Section 12.2 or 12.4 of said Agreement, but does not terminate this
      --------------------
Agreement, ABI shall use commercially reasonable best efforts to arrange for
adequate supply of Product to APP for sales in the Territory for the duration of
this License Agreement. In each case, ABI shall provide that the supplier of
Product to APP shall be responsible for the purity and conformance to
Specifications of the Product supplied to APP, and shall indemnify ABI and APP
to the same extent as APP indemnifies ABI under the Manufacturing Agreement.

        2.5 Except as otherwise agreed to by the Parties:

            (A) APP's license is limited to the Territory, and no APP Party may
     directly or indirectly market, distribute, sell or offer to sell the
     Product outside the Territory, nor may any APP Party directly or indirectly
     market, distribute, sell or offer to sell the Product to anyone that it has
     knowledge intends to, or reasonably believes intends to, directly or
     indirectly market, distribute, sell or offer to sell the Product to anyone
     outside the Territory.

            (B) Except as provided in Section 9, (i) no ABI Parties may directly
     or indirectly market, distribute, sell or offer to sell the Product inside
     the Territory, nor (ii) may ABI or its Affiliates sell the Product to
     anyone that it has knowledge intends to, or reasonably believes intends to,
     directly or indirectly market, distribute, sell or offer to sell the
     Product to anyone inside the Territory.

        2.6 So long as APP has made all milestone payments required under
Section 9, the license to APP shall convey the exclusive right to market and
---------
sell the Product in the Territory. If APP fails to make a milestone payment
required by Section 9, then the license to APP shall be limited to those
            ---------
oncology indications for which milestone payments have been made under Section
                                                                       -------
9, and ABI may, in its discretion, market or license the Product in the
-
Territory, for those indications for which APP did not make milestone payments.
Neither Party will be responsible to the other Party for the distribution or
sale of the Product other than by itself or its Affiliates for indications other
than those as to which it holds express rights under this Agreement, at the time
of the distribution or sale.

        2.7 Except as expressly provided in Section 14, nothing in this Section
                                            ----------                  -------
2 or otherwise in this Agreement will confer any right to use in advertising,
-
publicity or other promotional activities any name, trademark or trade name of
ABI.

     3. Transfer of Technology; Improvements. ABI will convey and disclose in
        ------------------------------------
tangible form to APP, as soon as reasonably practicable after the Effective Date
and throughout the term of this Agreement, all Technology. Each Party agrees to
as soon as reasonably practicable disclose in tangible form to the other Party
all modifications and improvements made to the Technology during the term of
this Agreement. APP will immediately transfer to ABI all right, title and
interest in and to any process, product, composition, or product-by-process, or
any improvements thereto, including inventions ("Developments"), made by the APP
Parties using

<PAGE>

ABI's processes or outputs ("Processes") (collectively, the "ABI Owned
Developments"). From and after their development, the ABI Owned Developments
will be included within the scope of the license granted to APP under this
Agreement. APP will own any Developments made by APP or its assignees using any
process or output other than the Processes, provided such Developments are
developed solely by APP or its assignees without any input from ABI or any of
its employees, including Patrick Soon-Shiong. Any Developments that are
developed solely by APP without using any Processes are referred to as the "APP
Owned Developments." APP may take whatever steps it deems necessary to protect
its rights in the APP Owned Developments. APP further grants to ABI, subject to
Section 17.2, a perpetual, royalty-free license to use all of the APP Owned
------------
Developments that are used or needed by APP in the manufacture or
commercialization of the Product.

     4. Marketing. Subject to Section 9, APP will use reasonable commercial
        ---------
efforts to market, distribute and sell the Product under the license granted
under this Agreement. Those efforts will include marketing, distributing and
selling the Product on its own merits and not in a manner instead intended to
promote other Products. Any advertising of the Product by the APP Parties must
be free from unwarranted statements and all advertising and promotional
materials will be subject to the review and comment of ABI. APP will continue to
promote the sale of the Product in the Territory during the term of this
Agreement, and will maintain the types of facilities, places of business,
approvals, employees (or third party representatives) that are necessary to do
so.

     5. Representation and Warranties of the Parties. Each Party represents to
        --------------------------------------------
the other Party that as of the date of this Agreement:

        5.1 The Party (A) is a corporation duly organized, validly existing and
in good standing under the laws of its jurisdiction of incorporation and (B) has
full power and authority to execute and deliver this Agreement and to perform
its obligations under this Agreement;

        5.2 This Agreement constitutes the valid and legally binding obligation
of the Party and is enforceable against the Party in accordance with its terms;

        5.3 Except as limited in Section 6, the execution and delivery of this
                                 ---------
Agreement and the performance of its obligations under this Agreement by the
Party will not cause the Party to violate or contravene (A) the Party's articles
of incorporation or bylaws, (B) any instrument, agreement or understanding by
which the Party or any of its Affiliates is bound or affected, or (C) any Legal
Requirement by which the Party or its properties or assets is bound or affected;
and

        5.4 The Party is not required to obtain a consent, approval or license
from any Person to execute, deliver and perform this Agreement (except for
Regulatory Approvals contemplated under this Agreement), and except for the
consent approvals or licenses that have been duly obtained by the Party.

     6. Representation and Warranties of ABI. ABI represents and warrants to APP
        ------------------------------------
that as of the date of this Agreement:

<PAGE>

        6.1 ABI owns and has the unrestricted and enforceable right to use,
develop and commercialize the Technology and the Product in the Territory, and
may enter into this Agreement. To ABI's knowledge, all prior art was disclosed
in the course of the prosecution of the patents included in the Technology that
ABI was aware would cause such patents to be invalid or unenforceable. Subject
to the immediately preceding sentence, ABI makes no representation as to the
validity or enforceability of any patent relating to the Product.

        6.2 ABI has not previously assigned, licensed, sublicensed, encumbered
or otherwise transferred to any third party any of the Technology or the Product
in the Territory;

        6.3 To ABI's knowledge, there are no Actions that are pending or, to the
knowledge of ABI, threatened, that challenge the rights of ABI or its licensees
to develop, use or commercialize the Technology or the Product;

        6.4 To ABI's knowledge, ABI has provided APP with all material
information with respect to its clinical trials for the Product;

        6.5 To ABI's knowledge, ABI has not used in any capacity the services of
any person debarred under Section 3.6 of the Federal Food, Drug and Cosmetic Act
                          -----------
in connection with the NDA filed for Product;

        6.6 No royalties are due to third parties by APP for sales of the
Product;

        6.7 ABI has taken, and will continue to take, reasonable security
measures to protect the secrecy, confidentiality and value of the Technology;
and

        6.8 To ABI's knowledge, ABI's activities to date relating to the
Technology and the Product have not been, and the planned and proposed
development, use and commercialization of the Technology and the Product will
not be in violation or contravention of the patent, intellectual property, trade
secret or other rights of any third party. Neither ABI, its Affiliates or
employees nor, to ABI's knowledge, ABI's agents, advisors or consultants, has
received any written or oral communication (A) alleging that it has violated, or
by use, development or commercialization of the Technology or Product would
violate, the patent, intellectual property, trade secret or other rights of any
third party or (B) that otherwise challenges ABI's rights with respect to the
Technology or the Product.

        6.9 EXCEPT AS EXPRESSLY PROVIDED IN SECTIONS 6.1 - 6.8, ABI (A)
                                            ------------------
SPECIFICALLY DISCLAIMS ALL WARRANTIES OF ANY KIND REGARDING THE PRODUCT OR THE
TECHNOLOGY, INCLUDING ANY WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE, (B) MAKES NO REPRESENTATION REGARDING THE SUITABILITY OF THE
PRODUCT OR ANY OF THE TECHNOLOGY FOR ANY THIRD PARTY'S REQUIREMENTS, AND (C)
MAKES NO REPRESENTATION AS TO WHETHER OR NOT THE TECHNOLOGY INFRINGES ON THE
PATENT OR OTHER PROPRIETARY RIGHTS OF ANY THIRD PARTY.

<PAGE>

     7. APP Representations and Warranties.
        ----------------------------------

        7.1 APP represents and warrants to ABI that, as of the date of this
Agreement, none of the executive officers of APP has any knowledge that any of
ABI's representations and warranties are inaccurate. For purposes of this
Section 7.1, the knowledge of Patrick Soon-Shiong shall be imputed to ABI rather
-----------
than to APP.

        7.2 APP acknowledges and agrees that none of APP or its Affiliates has
or claims to have ownership or license rights to the Technology or Product
except as set forth in this Agreement. APP agrees that neither ABI nor any third
party has promised, offered or conveyed to APP any interest in the Technology or
Product except as set forth in this Agreement and the Manufacturing Agreement.

     8. Up-Front Payment; IPO.
        ---------------------

        8.1 APP shall pay to ABI:

            (A) $15 million on a date designated by ABI to APP on at least two
     (2) days written notice, which payment date shall not be earlier than 30
     days nor later than 45 days following the execution of this Agreement;

            (B) $10 million upon the earlier of (1) January 15, 2002 or (2) 30
     days following APP's IPO; and

            (C) $35 million upon the earlier of (1) January 15, 2003 or (2) 30
     days following APP's IPO.

        8.2 Despite the provisions of the relevant instruments, ABI is required
to repay APP any amounts owing under the Demand Promissory Note dated July 24,
2001 and as amended and restated in October, 2001, and the Letter Agreement
dated October 21, 1999, no later than the earlier of (A) the five year
anniversary of the execution of this Agreement, and (B) the payment of $75
million by APP to ABI under Section 10. Notwithstanding the foregoing, APP shall
be allowed to take as a credit against the payments of Section 8.1(C) in excess
of $25 million, any amounts above $22 million advanced to ABI by APP. Promptly
after the execution of this Agreement, ABI and APP will enter into an agreement
to secure ABI's obligation under this Section 8.2.

     9. Milestone Payments.
        ------------------

        9.1 In addition to the payments provided for in Section 8, Section 10
                                                        ---------  ----------
and Section 11, upon notice to APP from ABI of the achievement of the following
    ----------
milestones, and within 30 days of that notice (subject to the provisions of
Sections 9.4 and 9.5), APP is required to make the following respective one-time
--------------------
payments:

            (A) $10 million upon notification that the FDA has accepted for
     filing ABI's NDA for the Product for a breast cancer indication;

<PAGE>

            (B) $15 million upon FDA approval of the NDA for the Product for a
     breast cancer indication;

            (C) $7.5 million upon the first publication in a United States
     top-tier peer- reviewed journal associated with a professional association
     of the Product's positive final Phase II results of lung cancer clinical
     trials;

            (D) $5 million upon notification that the FDA has accepted for
     filing ABI's NDA for the Product for a lung cancer indication;

            (E) $5 million upon FDA approval of the NDA for the Product for a
     lung cancer indication;

            (F) $7.5 million upon the first publication in a United States
     top-tier peer-reviewed journal associated with a professional association
     of the Product's positive final Phase II results of ovarian cancer clinical
     trials;

            (G) $5 million upon notification that the FDA has accepted for
     filing ABI's NDA for the Product for an ovarian cancer indication;

            (H) $5 million upon FDA approval of the NDA for the Product for an
     ovarian cancer indication;

            (I) $7.5 million upon the first publication in a United States
     top-tier peer- reviewed journal associated with a professional association
     of the Product's positive final Phase II results of prostate cancer
     clinical trials;

            (J) $5 million payments upon the first publication with respect to
     each other indication established for study by the Steering Committee (as
     defined in Section 12.3) in a United States top-tier peer-reviewed journal
     associated with a professional association of the Product's positive final
     Phase II results of clinical trials;

            (K) $10 million upon FDA approval of the NDA for the Product for a
     prostate cancer indication; and

            (L) $10 million upon FDA approval of the NDA for each other
     indication established for study by the Steering Committee.

        9.2 With respect to any publication milestones, if the Parties do not
reasonably agree that prescribers are entitled to be reimbursed for the
applicable indications as a consequence of the publication, the respective
payment will be reduced to $5 million.

        9.3 No milestone payment with respect to lung, ovarian or prostrate
cancers, or other cancer indications will be due and payable prior to Regulatory
Approval of the NDA for a breast cancer indication.

        9.4 In the event one or more of the milestone payments under Section 9.1
                                                                     -----------
(A) - (H) are due before APP has an IPO, and ABI at that time owns or controls
---------                                ---
at least fifty percent

<PAGE>

(50%) of APP's capital stock, APP shall be allowed to pay such milestone
payment(s) plus interest at a rate of 8% per year on the unpaid amount from the
due date until paid, rather than within 30 days of notice as stated in Section
9.1, by paying ABI seventy-five percent (75%) of the Gross Profits until the
earlier of (i) the date on which the payments of additional 25% of Gross Profits
has been equal to the amount of such deferred milestone payments and (ii) APP's
IPO, at which time APP shall pay all amounts that remain due and owing within 30
days. In the event one or more of the milestone payments under Section 9.1(A) -
(H) are due before APP has an IPO, and ABI at that time owns or controls less
than fifty percent (50%) of APP's capital stock, and APP fails to make the
milestone payment when due, APP shall have no right to use, market, distribute,
import, export, sell or offer to sell the Product for such indication. Any
marketing or distribution of Product for such indication by APP after such
failure to make a milestone payment will be a breach of this Agreement by APP.
From and after APP's failure to make such milestone payment, ABI will have the
right to use the Technology for the relevant indication in any manner it deems
appropriate, including use within the Territory.

        9.5 APP may decline to make the milestone payments set forth in
subsections (I), (J), (K) and (L) of Section 9.1 if, and only if, at the time
---------------------------------    -----------
that the milestone is met and notice is provided by ABI to APP, Net Sales of the
Product by APP do not, in the aggregate, equal or exceed $250 million (the
"Milestone Minimum").
 -----------------

            (A) If, upon 30 days notice from ABI that it has achieved a
     milestone set forth in subsections (I), (J), (K) or (L) of Section 9.1, APP
     has achieved the Milestone Minimum, then APP is required to pay to ABI the
     milestone payment provided for in the relevant subsection.

            (B) If, upon 30 days notice from ABI that it has achieved a
     milestone set forth in subsections (I), (J), (K) or (L) of Section 9.1, APP
     has not achieved the Milestone Minimum, then upon notice from ABI, APP is
     required to pay to ABI the milestone payment provided for in subsections
     (I), (J), (K) or (L) of Section 9.1 or indicate in writing that it is
     declining to make the payment. APP's failure to make a certain milestone
     payment in subsections (I), (J), (K) or (L) of Section 9.1, or to indicate
     that it is declining to make such a payment if the Milestone Minimum has
     not been achieved, will be deemed a declination by APP to make such
     milestone payment.

            (C) Following APP's declination or deemed declination to make a
     milestone payment, upon each declination or deemed declination, the
     relevant indication for which the milestone set forth in subsections (I),
     (J), (K) or (L) was achieved will no longer be included within the license
     grant to APP and APP will have no further right to use, market, distribute,
     import, export, sell and offer to sell the Product for such indication. Any
     marketing or distribution of Product for such indication by APP after its
     declination or deemed declination to make the milestone payment will be a
     breach of this Agreement by APP. From and after the declination or deemed
     declination by APP, ABI will have the right to use the Technology for the
     relevant indication in any manner it deems appropriate.

<PAGE>

        9.6 Once a milestone payment has been made under this Section 9 for a
particular indication (e.g., breast cancer), no additional payment shall be due
for label expansion or improvements within such indication.

    10. Share of Gross Profit or Loss.
        -----------------------------

        10.1 APP will pay to ABI:

             (A) Except as set forth in Sections 9.4 and 9.5 and Section
    10.1(B), [50% of the Gross Profits on sales of the Product in the Territory
    by the APP Parties. For purposes hereof, Gross Profits on sales of the
    Product by APP's permitted sublicensees in the United States is the greater
    of actual Gross Profits of the sublicensees or the Gross Profits that APP
    would have earned based upon its recent prior results if it had sold the
    Product itself in the United States rather than through a permitted
    licensee.

             (B) 50% of the consideration received by APP from any sublicensees
    in Canada and Mexico, in consideration for the grant of sublicenses of
    Technology, as permitted in Section 2.2 herein. As used in this Section
    10.1(B), consideration shall include amounts received from such sublicenses
    for the sale of Product to them by APP or its Affiliates, less the Actual
    Cost of such Product (as defined in Section 10.6).

        10.2 Except as provided in Section 16, APP's obligation to pay a
                                   ----------
percentage of the Gross Profits or consideration received by the APP Parties
will cease on a country-by-country basis within the Territory, after expiration,
in each respective country, of the last to expire of all patents listed on
Exhibit A, as such Exhibit A may be amended from time to time by mutual
---------          ---------
agreement of the Parties. Despite the foregoing, such obligation shall not cease
in the event the APP Parties sell the Product in such a country using the ABI
Brand Names.

        10.3 APP must make the payments due under this Section 10 within 45 days
                                                       ----------
following the end of, and with respect to sales of the Product by the APP
Parties during, each calendar quarter. If any payment due under Section 10 is
                                                                ----------
not made when due, interest will accrue at the rate of 8% per year on the unpaid
amount from the due date until the date of the payment.

        10.4 If there is a Gross Loss in any calendar quarter, no payment is
required for that quarter, and the amount of the Gross Loss will be carried
forward and reduce the amount of Gross Profits for the next calendar quarter
(and, as necessary, carried forward to successive quarters until the full amount
of Gross Loss has been offset by subsequent Gross Profit). Pre-launch selling
and marketing expenses of APP under this Agreement will be treated as a
deduction from Net Sales in the first calendar quarter of sales under this
Agreement.

        10.5 Within 45 days following the end of each calendar quarter (and
accompanying any payments made to ABI under this Section 10), APP must supply
                                                 ----------
ABI with a report, on behalf of the APP Parties, setting forth in reasonable
detail the calculation of ABI's share of Gross Profits (or Losses). APP must
keep and maintain, and must cause the APP Parties to keep and maintain, detailed
and accurate books and records with regard to Gross Profits (or Losses), Net
Sales, and the calculations for Gross Profits (or Losses) and Net Sales. A
nationally known independent certified public accounting firm selected by ABI
(which must be (A) other than APP's designated certified public accounting firm,
(B) reasonably acceptable to APP, and

<PAGE>

(C) bound in confidence not disclose any information except to inform ABI of
discrepancies) will be entitled, for purposes of determining compliance with
this Section 10, to review and audit the books and records of the APP Parties
     ----------
from time to time, but no more than three times a year as to each such party,
during normal business hours upon reasonable notice to the relevant APP Party
and at ABI's expense. Provided however, if the review or audit shows an
underpayment of more than 10% for the applicable period, the relevant APP Party
will bear the expense. The findings of the accounting firm will be binding on
the Parties.

        10.6 At the end of each calendar year, the parties shall "true up" the
Gross Profits (or Losses) applicable to APP manufactured Product sold by the APP
Parties in the Territory as follows:

             (A) Within 45 days after the end of each calendar year, APP shall
    determine its Actual Costs of manufacturing Product during such calendar
    year. The Actual Costs shall be APP's actual direct and indirect costs of
    manufacturing Product, including without limitation the materials,
    components, facility maintenance and depreciation, utilities, and labor and
    overhead, attributable to Production, processing, packaging and quality
    control of Product manufactured by APP and sold by it during such calendar
    year. The Actual Costs shall include an allowance for the costs of Bad
    Batches, as set forth in Section 10.6(B). On the basis of such Actual Costs,
                             ---------------
    APP shall calculate its revised Chargeable Price for such calendar year,
    which shall be determined by substituting Actual Costs for Standard Costs in
    the formula set forth in Section 1.5 (the "Revised Chargeable Price"). If
    the aggregate Revised Chargeable Price is less than the aggregate Chargeable
    Price originally included in the determination of Gross Profits (or Losses)
    for all Product sold during such calendar year, then APP shall remit to ABI
    one-half of such difference. If the aggregate Revised Chargeable Price is
    greater than the aggregate Chargeable Price originally included in the
    determination of Gross Profits (or Losses) for all Product sold during such
    calendar year, then ABI shall remit to APP one-half of such difference. APP
    shall include such calculations in its accounting report which is due 45
    days after the end of each calendar year.

             (B) For purposes of determining Actual Costs, APP shall be
    permitted to include the costs of actual Bad Batches manufactured by APP
    [***]

             (C) In addition to, and separate and apart in all respects from the
    provisions of Section 10.6(B), the costs of Bad Batches in the first
                  ---------------
    seventeen batches manufactured after the Effective Date (excluding pilot or
    pilot scale batches), shall be borne equally by the Parties. ABI shall
    reimburse APP for 50% of such costs, and APP's share of such costs shall be
    omitted from all calculations of Standard Costs and Actual Costs.

             (D) As used in this Section 10.6, "Bad Batches" shall mean batches
                                 ------------
    of Product which are lost in the course of manufacture, or are determined by
    APP not to be suitable for release. Notwithstanding the foregoing, Bad
    Batches shall not include pilot or pilot scale batches.

<PAGE>

    11. Sales Achievement Milestone Payments. APP is required to make the
        ------------------------------------
highest of the following milestone payments that have been achieved but not yet
paid to ABI within 30 days following the end of the calendar year in which the
indicated level of annual Adjusted Net Sales of the Product has been attained or
exceeded by the APP Parties:

    Annual Adjusted Net Sales          Milestone Payment
    -------------------------          -----------------

    [***]                              $10 million
    [***]                              $20 million
    [***]                              $30 million
    [***]                              $50 million

    For the sake of clarity, each such milestone payment shall be made one time
only, if at all, during the course of this Agreement. If an indicated level of
Adjusted Net Sales is attained in a calendar year but the corresponding
milestone payment has previously been paid, APP shall pay the next lowest level
of unpaid milestone payments, if any. For purposes of this Section 11,
                                                            ----------
"Adjusted Net Sales" means Net Sales as defined in Section 1.18 but without the
                                                   ------------
deduction contained in Section 1.18(D).
                       ---------------

    12. Further Development of the Product.
        ----------------------------------

        12.1 ABI will diligently pursue development of the Product for the
indications of breast, lung, ovarian and prostate cancers, according to the
objectives established by the Steering Committee. The Steering Committee will
reasonably determine the claims desired, the design, conduct and desired
endpoints of clinical trials, regulatory submissions to be made, timelines,
indications (other than those referred to above) to be studied and petitioned,
and other objectives of development and of lifecycle management efforts (e.g.,
Phase IIIb/IV) (the "Development Issues").
                     ------------------

        12.2 All developments will be performed at ABI's sole cost and expense,
but APP must provide to ABI, as requested by ABI (A) up to $2 million of the
Product (based on Chargeable Price) free of charge, [***].

        12.3 The steering team will be comprised of three representatives from
each of ABI and APP (the "Steering Committee"), and is required to meet in
                          ------------------
person or by conference call at least once every three months, or more often as
needed. Each Party's representatives must reasonably cooperate in establishing
meeting dates, setting agendas, attending and conducting the meetings, and
working diligently toward, and contributing to, the goals and business of the
Steering Committee and the Development Issues.

        12.4 If consensus cannot be reached on one or more Development Issues,
APP's representatives will be entitled to make the final decision with respect
to breast, lung and ovarian indications and ABI's representatives will be
entitled to make the final decision for all other indications.

    13. Regulatory Filings/Approvals.
        ----------------------------

        13.1 ABI will be responsible for and required to:

<PAGE>

             (A) make all filings, and other submissions, to the applicable
    governmental agency, department or other body regarding or relating to the
    Product; and

             (B) obtain all Regulatory Approvals to develop, test, market, and
    distribute the Product in the Territory in the manner and for the
    indications indicated in this Agreement and determined by the Steering
    Committee, except for filings and other submissions required to be made by
    APP for the manufacture of the Product as set forth in the Manufacturing
    Agreement.

        13.2 APP will reasonably cooperate with ABI in its efforts under Section
                                                                         -------
13.1. All costs and expenses associated with the foregoing with respect to a
----
particular indication will be borne by ABI until ABI obtains FDA approval of the
NDA for such indication. Thereafter, for each indication for which APP makes the
milestone payment under Section 9, although ABI will continue to be responsible
                        ---------
for regulatory filings and the maintenance of such approvals, APP will promptly
reimburse ABI for any further direct costs incurred with respect to the
maintenance of such regulatory approvals for each such indication in the
Territory upon presentation of documentary evidence of these types of payments.

        13.3 ABI will use all commercially reasonable efforts to diligently and
aggressively pursue the development of the Product for breast, lung and ovarian
indications.

    14. Use of Brand Names.
        ------------------

        14.1 During the term of this Agreement, and as permitted under Section
                                                                       -------
16.2, and except for those indications for which APP does not make payments
----
under Section 9, APP will have the right to market, distribute, import, export,
      ---------
offer to sell and sell the Product in the Territory using any brand name
included in an NDA that is approved by the FDA or otherwise established by ABI
for the Product ("ABI Brand Names") and no other party will have such right in
                  ---------------
the Territory. APP shall have such right to the full extent that ABI has the
right to use ABI Brand Names. Any use by APP of ABI Brand Names will be subject
to ABI's comments and may not impair or dilute the value of the names. Except as
provided under Section 16 APP may not sell the Product using any other brand
               ----------
names.

        14.2 As between ABI and APP, ABI will be the sole owner of all ABI Brand
Names and hereby grants APP a royalty-free trademark license for the use of ABI
Brand Names, subject to the other payment provisions in this Agreement.

        14.3 In connection with its use of ABI Brand Names, APP must:

             (A) credit ABI for ownership of the ABI Brand Names in any
    marketing efforts in which it uses any ABI Brand Names;

             (B) at its expense, take whatever action may be required under any
    Legal Requirement to use any ABI Brand Names in the Territory or refrain
    from taking any action that could impair or dilute the value of any ABI
    Brand Names; and

<PAGE>

             (C) reasonably cooperate with ABI in connection with any Action
    relating to the use by ABI (or its licensees, including APP) of any ABI
    Brand Names that APP is using.

    15. No Restriction on Competition. Nothing in this Agreement will be deemed
        -----------------------------
to prohibit either Party from developing, making, using, marketing or otherwise
distributing or promoting Products competitive with the Product.

    16. Term.
        ----

        16.1 This Agreement will commence on the Effective Date and, except as
provided in this Section 16 and Section 17 will continue until the date of
                 ----------     ----------
expiration of the last patent containing a valid claim that would be infringed
by the use, marketing, sale or distribution of the Product, including in
finished form, but upon the expiration, APP will have a fully-paid, royalty-free
(except as provided in Section 16.4) irrevocable, non-exclusive right to use,
                       ------------
market, sell and distribute the Product in the Territory except for those
indications for which APP does not make payments under Section 9.
                                                       ---------

        16.2 If APP desires to continue to sell Product using ABI Brand Names
after the expiration of such last patent, it may, except for those indications
for which APP does not make payments under Section 9, do so by providing ABI
                                           ---------
with six months notice prior to such expiration of APP's desire to extend the
license to ABI Brand Names, as provided in Section 14.1. Except as provided in
                                           ------------
Section 16.3, this Agreement will continue for successive one-year terms
------------
thereafter (the "Extension Periods") until APP provides ABI with a minimum of
                 -----------------
six months notice of APP's intention to terminate.

        16.3 If, during the Extension Periods, the APP Parties are selling the
Product under any ABI Brand Name while concurrently selling Product in a generic
form, ABI will have the right to terminate this Agreement upon notice to APP
during any calendar year that Gross Profits for sales of the Product by such
Parties using one or more ABI Brand Names are not at least equal to 50% of Gross
Profits for sales of the Product using ABI Brand Names, in the calendar year
immediately prior to the first Extension Period.

        16.4 So long as the APP Parties continue to sell Product under an ABI
Brand Name, APP must pay to ABI the percentage of Gross Profits or consideration
that APP would be obligated to pay to ABI under Section 10 but only for sales of
                                                ----------
the Product sold using ABI Brand Names. During an Extension Period, the APP
Parties shall have no payment or royalty obligations to ABI for sales by APP
Parties of Product sold under any name other than an ABI Brand Name.

    17. Termination.
        -----------

        17.1 This Agreement may be terminated:

             (A) At any time by mutual agreement of the Parties;

             (B) Immediately, by the non-defaulting Party, if the other Party:

<PAGE>

            (1) commits a material breach or default ("Breach") under this
    Agreement, which Breach is not remedied within 60 days after the receipt of
    written notice of the Breach by the Party in Breach (except as to the
    payment of money by APP, for which the notice period will be 10 days).
    Notwithstanding the foregoing, if the Breach is not curable in 60 days and
    the breaching or defaulting party in good faith notifies the other party in
    writing prior to the 60 days that it is initiating cure of the Breach, and
    initiates cure of such Breach within 60 days after the initial notice and
    in good faith continues diligently to attempt to cure the Breach, then
    this Agreement shall not be terminated pursuant to this Section
                                                            --------
    17.1(B)(1). Provided, however, it shall not be a breach of the Agreement if
    ----------
    APP does not make one or more of the milestone payments under Section 9.1
                                                                  -----------
    (A) - (H), but rather, in such instance and subject to Section 9.4, APP
    ---------                                              -----------
    shall immediately lose all right to use, market, distribute, import, export,
    sell and offer to sell the Product for such indication and that indication
    for which the payment was not made shall not longer be included within the
    license grant to APP. From and after APP's failure to make a milestone
    payment, ABI will have the right to use the Technology for the relevant
    indication in any manner it deems appropriate, including use within the
    Territory.

            (2) made a material misrepresentation of any representation or
    warranty contained in this Agreement; or

            (3) has a permanent or temporary restraining order, preliminary
    injunction or other order granted against it by a court or authority
    enjoining or restricting the sale of the Product as contemplated hereby in
    the Territory. Notwithstanding the foregoing, if any such order results or
    would foreseeably result in a decline of 10% or less of units of Product
    sold in the Territory as compared to the prior calendar year's sales of
    units of Product sold in the Territory, then this Agreement shall not be
    terminated pursuant to this Section 17.1(B)(3).
                                ------------------

       (C) Following a 60-day period after written notice to cure such
condition, by either ABI or APP if the other Party:

            (1) does not pay its debts generally as they become due, or is
    unable to pay its debts generally as they become due;

            (2) has or has instituted against it any proceeding seeking to
    adjudicate it bankrupt or insolvent, or seeking liquidation, winding up,
    reorganization, arrangement, adjustment, protection, relief or composition
    of it or its debts under any law relating to bankruptcy, insolvency or
    reorganization or relief of debtors;

            (3) makes a general assignment for the benefit of creditors;

            (4) seeks the entry of an order for relief or the appointment of a
    receiver, liquidator, sequestrator, trustee, custodian or similar official
    for it; or

<PAGE>

              (5) takes advantage of any other law or procedure for the
    protection of creditors.

        17.2  Upon the termination of this Agreement by ABI pursuant to Section
                                                                        -------
17.1, the rights and license granted to APP under this Agreement and
----
APP's obligations under Sections 8, 9, 10 and 11 (except to the extent earned
but not yet paid) will terminate, sublicenses will terminate, and ABI's
obligations to provide Technology or information will cease. The rights and
license to APP under this Agreement, and the sublicenses granted thereunder,
shall survive termination of this Agreement by ABI for any other reason. Except
to the extent that any monies are owned and not yet paid and for the provisions
of Sections 5, 6, 7, 17, 18, 19, 20, 21, 22, 23, 25, 26, 32, and 33, none of the
   -------- -  -  -  --  --  --  --  --  --          --  --      --
provisions of this Agreement shall survive termination. Upon the termination by
APP under Sections 17.1(B) or (C), ABI's license to APP Owned Developments shall
          -----------------------
also terminate. Upon ABI's termination of this Agreement pursuant to Section
                                                                     -------
17.1, ABI will have the right to concurrently terminate the Manufacturing
----
Agreement.

        17.3  Termination is not the sole remedy under this Agreement, and
whether or not termination is effected, all other remedies remain available to
each Party.

    18. Confidentiality.
        ---------------

        18.1  Each Party recognizes that the other Party holds its Proprietary
Information as important. In particular, each Party recognizes that the other
Party's Proprietary Information (and the confidential nature thereof) is
critical to the other Party's business and that neither Party would enter into
this Agreement without assurance that such information and the value thereof
will be protected as provided in this Section 18 and elsewhere in this
                                      ----------
Agreement.

        18.2  Each Party must, therefore:

              (A) Hold the other Party's Proprietary Information in confidence
    and take reasonable precautions to protect the Proprietary Information
    (including, without limitation, no less than all precautions that it
    employs with respect to its own confidential materials);

              (B) not divulge (except pursuant to a sublicense expressly
    authorized in this Agreement) the other Party's Proprietary Information
    or any information derived therefrom to any third person; and

              (C) not make any use whatsoever at any time of the other Party's
    Proprietary Information except for purposes of and expressly authorized in
    this Agreement.

        18.3  Any employee given access to any Proprietary Information must have
a legitimate "need to know" and must be bound in writing to maintain the
confidence of information to which it is given access.

        18.4  Without granting any right or license, the disclosing Party agrees
that the foregoing restrictions will not apply with respect to information that
the receiving Party is able to demonstrate by competent evidence:

<PAGE>

            (A) is in or (through no improper action or inaction by the
    receiving Party or any Affiliate of the receiving Party or its agents or
    employees) enters the public domain (and is readily available without
    substantial effort);

            (B) was rightfully disclosed to it by another person without
    restriction; or

            (C) was independently developed by it by persons without access to
    such information and without use of any of the disclosing Party's
    Proprietary Information.

        18.5  Each Party's obligations under this Section 18 will terminate
                                                  ----------
five years after the date of termination or expiration of this Agreement. The
Parties recognize and acknowledge that prior to the Effective Date of this
Agreement, each Party has received the other Party's Proprietary Information and
each hereby agrees to protect the Proprietary Information to the same extent as
set forth in this Section 18.
                  ----------

        18.6  Immediately upon termination or expiration of this Agreement, each
Party will turn over to the other Party all Proprietary Information of the other
Party and all documents or media containing any Proprietary Information and any
and all copies or extracts thereof except insofar as necessary to practice the
license as set forth in Section 16.1.
                        ------------

        18.7  Each Party acknowledges and agrees that due to the unique nature
of Proprietary Information, there can be no adequate remedy at law for any
breach of each Party's obligations under this Section 18, that any breach may
                                              ----------
result in irreparable harm to the disclosing Party, and therefore, that upon any
breach or any threat of breach, the disclosing Party will be entitled to
appropriate equitable relief (without the posting of any bond) in addition to
whatever remedies it might have at law in connection with any breach or
enforcement of the receiving Party's obligations under this Agreement or the
unauthorized use or release of any Proprietary Information.

    19. Patent Matters.
        --------------

        19.1  ABI will, in a scientifically and commercially reasonable manner,
file and prosecute patent applications and maintain patents in the Territory
relating to the Technology, the ABI Owned Developments and any improvements made
by or on behalf of ABI ("ABI Developments").
                         ----------------

        19.2  APP will not attempt to file or prosecute any patent applications
or maintain any patent covering the Technology, the ABI Developments, or the ABI
Owned Developments except: (i) as ABI may, in its sole discretion, approve in
writing; (ii) in the event ABI elects to discontinue or abandon the prosecution
and/or maintenance of any patent or patent application covering the Technology
in the Territory, it shall provide adequate notice to APP and shall give APP the
opportunity to file, continue prosecution of, pay any issuance fee and/or
maintain such patent application and/or patent at APP's own expense.

        19.3  APP may take whatever steps it deems necessary to protect and
enforce its rights and interest in APP Owned Developments. ABI will not attempt
to file or prosecute any patent applications or maintain any patent covering the
APP Owned Developments.

<PAGE>

        19.4  If either Party becomes aware of any Product or activity of any
third party that involves or may involve infringement or other violation of any
patent relating to the Proprietary Information, APP Owned Developments (to the
extent related to the Product), ABI Owned Developments, ABI Developments or
other Proprietary Right in the Territory, that Party must promptly notify the
other Party in writing of the infringement or violation.

        19.5  ABI will have the first right, but not the obligation, to file
suit or take other action to prevent the infringement of any patents or
Technology owned by ABI related to the Product in the Territory. If ABI takes
such action, ABI will control any action undertaken by ABI against an infringer,
and ABI may enter into settlements, stipulated judgments or other arrangements
respecting the infringement, at its own expense unless the proposed settlements,
judgments or arrangements would adversely affect APP, in which case, they will
be subject to APP's consent which will not be unreasonably withheld. If ABI
takes such action, ABI will defend, indemnify and hold APP harmless from related
costs and expenses for such claimed infringement. APP will permit an action to
be brought by ABI in APP's name if required by law. APP agrees to provide all
assistance that ABI may reasonably require in any litigation, including
providing written evidence, deposition and trial testimony, for which ABI will
pay APP a reasonable hourly rate of compensation, together with reimbursement
for out-of-pocket costs. Any damages or other recovery from an infringement
action undertaken by ABI pursuant to this Section 19.5 to enforce ABI's
                                          ------------
Proprietary Rights relating to the Product sold in the Territory, will be used
first to reimburse ABI's legal costs and expenses incurred in the action and
thereafter any damages or other recovery relating to Products sold by the APP
Parties in the Territory will be shared equally with APP.

        19.6  If ABI does not, within 90 days after receipt of notice of a
patent infringement relating to the use of the Product sold by the APP Parties
in the Territory, commence action directed toward restraining or enjoining such
patent infringement, APP may take such legally permissible action as it deems
necessary or appropriate to enforce ABI's patent rights and restrain such
infringement at its own expense unless the actions would adversely affect ABI,
in which case they will be subject to ABI's consent which will not be
unreasonably withheld. If APP takes such action, APP will indemnify, defend and
hold harmless ABI in respect of any such action. Any damages or other recovery
from an infringement action undertaken by APP pursuant to this Section 19.6 to
                                                               ------------
enforce ABI Proprietary Rights on the Product sold in the Territory, will be
first used to reimburse APP's legal costs and expenses incurred in such action
and thereafter shared equally with ABI; provided if any portion of such damages
or other recovery relate to infringement outside the Territory or Product not
sold by the APP Parties in the Territory, such portion shall be paid 100% to
ABI.

        19.7  Each Party must fully cooperate with the other Party bringing any
action, including joining as a Party to the suit, if necessary, and also
including, without limitation, supplying essential documentary evidence and
making essential witnesses then in its employ available.

        19.8  If any third party threatens or commences a lawsuit against either
Party alleging the Product in any way infringes or otherwise violates any
Proprietary Rights of such third party, it shall promptly notify the other Party
in writing.

<PAGE>

    20. Adverse Experience Reporting; Recalls.
        -------------------------------------

        20.1  Each Party will report to the other Party any information of which
it becomes aware concerning any adverse drug experience in connection with the
use of the Product, including the incidence and the severity thereof. ABI will
provide to APP copies of any reports submitted to the FDA relating to any
adverse drug experiences that ABI determines to be significant.

        20.2  If ABI is required to initiate, or otherwise in its discretion
decides to initiate, a recall, withdrawal or field correction (collectively, a
"Recall") of the Product sold by the APP Parties in the Territory, ABI will
 ------
notify APP and provide a copy of its proposal with respect to such Recall,
including the Recall letter, for APP's review prior to ABI's initiation of the
Recall. If APP independently believes that a Recall of the Product sold by the
APP Parties in the Territory may be necessary or appropriate, it must notify
ABI, and the parties must fully cooperate with each other concerning the
necessity and nature of the Action.

        20.3  ABI will be responsible for all Recall activities with respect to
Recall of the Product. APP will reasonably cooperate with ABI in connection with
any Recall. Each Party will maintain complete and accurate Recall records
relating to the Product for any periods that are required by any Legal
Requirement.

        20.4 The fees, costs and expenses of any Recall (collectively, the
"Recall Expenses") of the Product will be apportioned between the Parties as
 ---------------
follows:

            (A) Except as provided in Section 20.4(C), ABI will pay all Recall
    Expenses related to Recalls of the Product outside the Territory.

            (B) Except as provided in Section 20.4(C), the Parties will share
    50%/50% all Recall Expenses related to Recalls of the Product sold by the
    APP Parties in the Territory.

            (C) If the Recall is a Manufacturing Recall as determined by an
    independent third party mutually agreed upon, then APP will pay all Recall
    Expenses.

            (D) In the event of a Recall of the Product outside the Territory as
    provided in Section 20.4(A) or for Manufacturing Recalls as provided in
    Section 20.4(C), the responsible Party shall promptly reimburse the other
    Party for any Recall Expenses the other Party incurred. In the event of a
    Recall of the Product in the Territory as provided in Section 20.4(B), each
    Party shall submit to the other Party on a quarterly basis an accounting of
    its Recall Expenses incurred, and the Party that incurred the lesser amount
    shall make a reconciling payment to the other Party for 50% of the
    difference.

    21.  Indemnification; Incidental And Consequential Damages.
         -----------------------------------------------------

        21.1 APP agrees to indemnify, defend and hold harmless the ABI Parties
from any Damages incurred by or assessed against the ABI Parties resulting from
a third party claim caused or alleged to be caused by:

<PAGE>

            (A) APP's failure to perform any of its obligations under this
    Agreement;

            (B) any breach of or inaccuracy in any representations or warranty
    made by APP in this Agreement;

            (C) any Product Liability Claim arising from the gross negligence,
    fraud or intentional misconduct of an APP Party;

            (D) a sublicesee's material breach of its sublicense under this
    Agreement or related to any gross negligence, fraud or intentional
    misconduct on the part of any sublicensee of APP; and

            (E) any Product Liability Claim directly resulting from the use of
    the Product that, when manufactured by APP, was adulterated or contaminated,
    or was otherwise caused by APP's failure to comply with this Agreement
    or the Specifications provided for in the Manufacturing Agreement.

        21.2  ABI agrees to indemnify, defend and hold harmless the APP Parties
from any Damages incurred by or assessed against the APP Parties resulting from
a third party claim caused or alleged to be caused by:

            (A) ABI's failure to perform any of its obligations under this
    Agreement;

            (B) any breach of or inaccuracy in any representations or warranty
    made by ABI in this Agreement;

            (C) any Product Liability Claim arising from the gross negligence,
    fraud or intentional misconduct of ABI Parties;

            (D) any Product Liability Claim directly resulting from the use
    and/or sale of the Product outside the Territory, except for those
    covered in Section 21.1(C) or Section 21.1(E);
               ---------------    ---------------
            (E) any Product Liability Claim directly resulting from the use
    and/or sale of the Product inside the Territory, when sold by ABI
    Parties for indications other than those licensed to APP, except for those
    covered in Section 21.1(C) or Section 21.1(E).
               ---------------    ---------------

        21.3  Except with respect to the APP Owned Developments or ABI Owned
Developments, ABI further indemnifies APP for any proceedings instituted by or
on behalf of a third party based upon a claim that the manufacture, use or sale
of the Product infringes a patent or any other proprietary right of that third
party. Such indemnification obligation shall be limited as follows:

            (A) to the extent such proceeding or settlement thereof results in a
    future royalty to be paid by APP, ABI's indemnity obligation shall be
    satisfied by having such royalty payment be a deduction from Net Sales; and

<PAGE>

            (B) to the extent such proceeding or settlement thereof results in a
        payment obligation other than as provided in Section 21.3(A) above, ABI
                                                     ---------------
        shall indemnify APP only to the extent of fifty percent (50%) of
        payments previously made by APP to ABI pursuant to Section 8.1 hereof,
                                                           -----------
        and any indemnity payments to be made by ABI to APP or on behalf of APP
        pursuant to the foregoing shall be limited to fifty percent (50%) of
        ABI's operating cash flow, including without limitation, the split of
        Gross Profits under this Agreement.

        21.4  If any Party entitled to be indemnified pursuant to this Section
                                                                       -------
21 (an "Indemnified Party") receives notice of the assertion by any Person of
--
any claim or of the commencement by any Person of any Action (any such claim or
Action being referred to herein as an "Indemnifiable Claim") with respect to
                                       -------------------
which another Party hereto (an "Indemnifying Party") is or may be obligated to
                                ------------------
provide indemnification, the Indemnified Party shall promptly notify the
Indemnifying Party in writing (the "Claim Notice"). However, the failure to
                                    ------------
provide the notice will not relieve or otherwise affect the obligation of the
Indemnifying Party to provide indemnification under this Agreement, except to
the extent that any Damages directly resulted or were caused by that failure.

        21.5  The Indemnifying Party will have 30 days after receipt of the
Claim Notice to undertake, conduct and control, through counsel of its own
choosing and at its expense, the settlement or defense of the claim, and the
Indemnified Party will cooperate with the Indemnifying Party in connection with
the settlement or defense, if:

            (A) the Indemnifying Party permits the Indemnified Party to
    participate in the settlement or defense through counsel chosen by the
    Indemnified Party (subject to the consent of the Indemnifying Party, which
    consent shall not be unreasonably withheld);

            (B) the fees and expenses of such counsel will not be borne by the
    Indemnifying Party; and

            (C) the Indemnifying Party does not settle any Indemnifiable Claim
    without the Indemnified Party's consent which consent may not be
    unreasonably withheld. So long as the Indemnifying Party is vigorously
    contesting any Indemnifiable Claim in good faith, the Indemnified Party may
    not pay or settle the claim without the Indemnifying Party's consent, which
    consent shall not be unreasonably withheld.

        21.6  If the Indemnifying Party does not notify the Indemnified Party
within 30 days after receipt of the Claim Notice that it elects to undertake the
defense of the Indemnifiable Claim described in the Claim Notice, the
Indemnified Party has the right to contest, settle or compromise the
Indemnifiable Claim in the exercise of its reasonable discretion. However, the
Indemnified Party must notify the Indemnifying Party of any compromise or
settlement of any such Indemnifiable Claim.

        21.7  Notwithstanding anything in this Section 21 to the contrary, APP
                                               ----------
is not entitled to assume the defense for any Indemnifiable Claim (and will be
liable for the reasonable fees and expenses incurred by the Indemnified Party in
defending the claim) if the Indemnifiable

<PAGE>

Claim seeks an order, injunction or other equitable relief (or other relief for
other than money damages) against ABI or its Affiliates which ABI determines,
after conferring with its counsel, cannot be separated from any related claim
for money damages and which, if successful, would adversely affect the
commercialization of the Product. However, if an equitable relief portion of the
Indemnifiable Claim can be separated from that for money damages, APP may assume
the defense of the portion relating to money damages.

    22. Product Liability.
        -----------------

        22.1  Subject to Section 21, each Party must promptly reimburse the
                         ----------
other Party for 50% of the amount of: (A) the costs of responding to or
defending any Product Liability Claim arising from use or sale of the Product in
the Territory, regardless of the reason for such claim except as expressly set
forth in Sections 21.1(C) or 21.1(E); and (B) any Damages payable by the Party
         ----------------    -------
following final judgment or settlement of any Product Liability Claim arising
from use or sale of the Product in the Territory regardless of the reason for
such claim except as expressly set forth in Sections 21.1(C) or 21.1(E). For the
                                            ----------------    -------
sake of clarity, the 50%/50% sharing ratio for Product Liability Claims arising
from the use or sale of the Product in the Territory (except as provided in
Sections 21.1(C) and 21.1(E) shall include, without limitation, claims based on
----------------     -------
allegations of latent defect, failure to warn, and the establishment of the
Specifications.

        22.2  For so long as ABI is conducting clinical trials of the Product or
commercially marketing and selling the Product, it must maintain Product
liability insurance with respect to the Product, with a reputable carrier, in
the amounts set forth in Exhibit B, naming APP and its Affiliates as additional
                         ---------
insureds.

        22.3 For so long as APP is commercially marketing and selling the
Product in the Territory, it must maintain Product liability insurance with
respect to the Product, with a reputable carrier, in the amounts set forth in
Exhibit C, naming ABI and its Affiliates as additional insureds.
---------

        22.4 Each Party must notify the other Party as promptly as practicable
if a Product Liability Claim under Section 22.1 is commenced or threatened
                                   ------------
against any Party. Each Party must cooperate with the other Party in connection
with any such Product Liability Claim that is commenced or threatened against
the other Party.

        22.5 If a Product Liability Claim under Section 22.1 is asserted against
                                                ------------
both Parties, each Party will have the right to designate counsel to defend
itself in the Product Liability Claim. If a Product Liability Claim under
Section 22.1 is brought against one Party but not the other Party, the named
------------
Party will (subject to Section 22.6) have absolute control of litigation,
                       ------------
except that:

            (A) the other Party may appoint counsel to participate in the
    defense of the Product Liability Claim if the named Party reasonably
    determines that the participation would not adversely affect the
    attorney-client privilege; and

            (B) if the litigation could reasonably be expected to have an
    adverse effect on the development and commercialization of the Product,
    the named Party must consult

<PAGE>

    with the other Party regarding the conduct of the litigation if the
    named Party reasonably determines that the cooperation would not adversely
    affect the attorney-client privilege.

        22.6  Neither Party may agree to a settlement of any Product Liability
Claim under Section 22.1 without the consent of the other Party, which consent
            ------------
may not be unreasonably withheld or delayed, if the settlement:

            (A) would have an adverse effect on the development or
    commercialization of the Product; or

            (B) would otherwise have a material adverse effect on the other
    Party.

    23. EXCEPT FOR BODILY INJURY OF A PERSON, NEITHER PARTY WILL BE LIABLE
HEREUNDER UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER LEGAL OR
EQUITABLE THEORY FOR ANY SPECIAL, INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES,
INCLUDING WITHOUT LIMITATION, LOSS OF PROFITS FROM THE USE OF (OR INABILITY TO
USE) THE TECHNOLOGY, THE DEVELOPMENT OR COMMERCIALIZATION OF THE PRODUCT OR
OTHERWISE IN CONNECTION WITH, OR ARISING OUT OF, THIS AGREEMENT.

    24. Independent Contractors. ABI and APP are independent Parties, and
        -----------------------
nothing contained herein will be construed to create a joint venture,
partnership or similar relationship. Neither Party is authorized to, nor may it,
make any statements, claims, representations, warranties or otherwise act in any
way so as to incur any liability whatsoever for which the other may become
directly, indirectly or contingently liable.

    25. Assignment.
        ----------

        25.1 The rights and obligations of the Parties under this Agreement may
not be assigned or transferred in any manner, including, without limitation, by
operation of law, sale of stock or sale of assets, without the prior written
approval, which shall not be unreasonably withheld, of the other Party (and any
attempt to do so will be void) except that:

            (A) rights to payment of money may be assigned without such
    approval, and

            (B) a Party has the right to assign this Agreement to its lenders as
    collateral security under a credit facility and following acceleration of
    that credit facility, it's lender has the right to assign this Agreement to
    a third party reasonably satisfactory to the other Party. Despite the
    foregoing, in no event shall ABI be obligated to consent to an assignment to
    a Competitor.

        25.2 Notwithstanding anything to the contrary in Section 25.1, if:
                                                         ------------
            (A) any Party:

                (1) merges or consolidates with any other corporation,
        partnership or other business entity, or

<PAGE>

                (2) all or substantially all of such Party's business or assets
            are transferred in any manner to any other corporation, partnership
            or other business entity; or

            (B) any other Person acquires the power, directly or indirectly, to
    direct or cause the direction of management and the policies of such Party
    (a "Change of Control");
        -----------------
    such event will be deemed an approved assignment for purposes of this
    Agreement if the conditions set forth in this Section 25.3 are satisfied.
                                                  ------------

        25.3  Following a Change of Control, such successor to such Party will
succeed to, and be subject to, all rights, interests, duties and obligations of,
and will thereafter be deemed for all purposes to be the applicable Party under
this Agreement. The successor to be approved under this Section 25.3 will be
                                                        ------------
require to:

            (A) have the experience, facilities, capabilities, and financial
    resources equal to or greater than such Party; and

            (B) expressly acknowledge, in a written instrument delivered to the
    other Party in a form reasonably acceptable to the Parties:

                (1) the succession to all duties and obligations of the Party
            under this Agreement, and

                (2) the existence of the requirements set forth in this Section
                                                                        -------
            25.
            --

        25.4  Despite the foregoing, for the purposes of this Agreement, an IPO
    will not be considered a Change of Control.

        25.5 If APP's successor does not meet the following requirements in
    Section 25.5(A) and 25.5(B) in each calendar year after a Change of Control
    ---------------     -------
    occurs, ABI may, at its sole option, convert the exclusive license to a
    non-exclusive license or terminate this Agreement:

            (A) spend on marketing and sales at least the same amounts that the
    APP Parties (other than those which have continuing agreements with such
    a successor) and its Affiliates and permitted assignees spent on marketing
    and sales in the calendar year prior to the Change of Control; and

            (B) achieve revenues that are greater than or equal to 90% of the
    greater of:

                (1) the revenues of the APP Parties (other than those which have
            continuing agreements with such a successor) in the calendar year
            prior to the Change of Control; or

<PAGE>

                (2) the average of the revenues of the APP Parties (other than
            those which have continuing agreements with such a successor) for
            the immediately preceding three calendar years.

        25.6 In the event a Change of Control, the foregoing amounts in Section
                                                                        -------
25.5 shall be prorated for the portion of the calendar year subsequent to the
----
Change of Control.

        25.7 If the successor entity fails to achieve the sales level required
in Section 25.5, such successor shall be entitled to make a supplemental payment
   ------------
to ABI (within 45 days after the end of each calendar year) of an amount equal
to: (A) the difference between its actual revenues from the Product and the
revenues required by Section 25.5, multiplied by (B) one-half (1/2) of its Gross
                     ------------
Profits from Product sales as a percentage of such actual revenues. Such
payment, if made, shall prevent ABI from exercising any other remedy under
Section 25.5 with respect to the calendar year for which such payment is made.
------------

        26. Notices. Any and all notices given pursuant to this Agreement must
            -------
be in writing, and will be deemed to have been properly given when delivered
personally or sent by facsimile, air courier, or post, to the respective address
shown below or such other address as shall be specified by the Party(ies)
pursuant to written notice given in accordance with this Section 26. Any notice
                                                         ----------
will be effective upon receipt, which will be deemed to occur one business day
after the facsimile is send, two business days the notice is sent by air
courier, and five calendar days after the notice is delivered to the US Postal
Service, properly marked and stamped for first class mail, return receipt
requested. Any and all notices must be sent:

     If to ABI to:

          American BioScience, Inc.
          2730 Wilshire Boulevard
          Santa Monica, California 90403
          Attention: Chief Executive Officer
          Facsimile: 310/998-8553

     With a copy to:

          [

          Attention:
          Facsimile:     ]

     If to APP to:

          American Pharmaceutical Partners, Inc.
          10866 Wilshire Boulevard
          Los Angeles, California 90024
          Attention: Chief Operating Officer
          Facsimile: 310/470-4222

     With a copy to:

<PAGE>

          American Pharmaceutical Partners, Inc.
          1101 Perimeter Drive
          Schaumburg, Illinois 60173
          Attention:  General Counsel
          Facsimile:  847/413-2670

    27. Force Majeure.
        -------------

        27.1 The obligations of a Party hereunder will be suspended during the
    time and to the extent that such Party is prevented from complying with its
    obligations due to any event or circumstances beyond the reasonable control
    and without the fault or negligence of the affected Party (which
    circumstance is referred to as "Force Majeure"), including but not limited
                                    -------------
    to inevitable accidents, perils of navigation, floods, fire, storms,
    earthquakes, lockouts, explosion, hostilities, war (whether declared or
    undeclared), acts of terrorism, civil disturbances, order or acts of any
    government, whether de jure or de facto or any official purporting to act
    under authority of any such government (other than as to Regulatory
    Approval), illegality arising from domestic or foreign laws or regulations,
    insurrections, quarantine or custom restrictions (other than due to the
    action or inaction of the Party claiming a Force Majeure), damage in
    factories or warehouses, strikes, lockouts, or other labor difficulty of the
    Parties, inability to obtain paclitaxel active pharmaceutical ingredient or
    other components and raw materials, lack of conveyance, breakdown of
    machinery or instruments or other disturbances of the Parties or their
    suppliers or acts of God or other similar event beyond the reasonable
    control of, as the case may be, ABI or APP that results in hindrance of the
    performance by the Party of its obligations under this Agreement.

        27.2 As soon as possible after being affected by a Force Majeure
    circumstance, the affected Party must furnish to the other Party all
    particulars of the Force Majeure and the manner in which its performance is
    prevented or delayed. The Party whose obligations under this Agreement have
    been suspended must promptly and diligently pursue appropriate action to
    enable it to lift the Force Majeure situation, except that such Party will
    not be obligated to settle any strike, lockout or other labor difficulty on
    terms contrary to its wishes.

        27.3 If any Force Majeure circumstance cannot be removed or overcome
    within 120 days (or such other period as the Parties mutually agree) from
    the date the Party affected first became affected, then the non-affected
    Party may, at the expiration of such period, by notice to the affected Party
    terminate this Agreement, and neither Party will be liable to the other for
    Damages.

        28. Amendment and Waiver. This Agreement (including the Exhibits hereto)
            --------------------
    may be amended, modified, superseded or canceled, and any other of the terms
    or conditions hereof may be modified, only by a written instrument executed
    by both Parties or, in the case of a waiver, by the Party waiving
    compliance. Failure of either Party at any time or times to require
    performance of any provision hereof will in no manner affect the right of
    such Party at a later time to enforce the same, and no waiver of any nature,
    whether by conduct or otherwise, in any one or more instances, will be
    deemed to be or considered as a further or continuing waiver of any
    provision of this Agreement.

<PAGE>

      29. Severability. If any one or more of the agreements, provisions or
          ------------
terms contained herein are declared invalid, illegal or unenforceable in any
respect, the validity of the remaining agreements, provisions or terms contained
herein will not be affected, prejudiced or invalidated thereby.

      30. Entire Agreement. This Agreement, the Security Agreement noted in
          ----------------
Section 8.2 and all Exhibits hereto, contain the entire agreement between the
-----------
Parties, and supersedes any prior agreements between them, with respect to the
subject matter hereof.

      31. Section Headings; Recitals. The section headings contained in this
          --------------------------
Agreement are for reference purposes only and do not affect in any way the
meaning or interpretation of this Agreement. The recitals are hereby
incorporated into this Agreement by reference.

      32. Governing Law. This Agreement shall be governed by and construed and
          -------------
enforced in accordance with the substantive law (without regard to conflicts of
law provisions) of the State of California.

      33. Arbitration; Equitable Relief.
          -----------------------------

             33.1 Except in the case of a Party seeking equitable relief
hereunder, any and all disputes or controversies, whether of law or fact and of
any kind and nature whatsoever, arising out of or relating to this Agreement,
will be decided by binding arbitration in accordance with Title 9 of the United
States Code and the Commercial Arbitration Rules of the American Arbitration
Association ("AAA"). For claims under $1,000,000, the arbitration will be held
              ---
before a single arbitrator. If the Parties are unable to agree on an arbitrator,
the arbitration will be held before an arbitrator selected by AAA. For claims
over $1,000,000, the arbitration will be held before a three-member panel of
arbitrators. If the Parties are unable to agree on a three-member panel of
arbitrators, the arbitration will be held before a three-member panel of
arbitrators selected by the AAA. Arbitration shall take place in Los Angeles
County, State of California, or such other location as may be agreed by the
Parties. Claims with respect to injunctive relief or specific performance will
be resolved by a court of law in accordance with Section 33.2. APP irrevocably
                                                 ------------
consents and submits to personal jurisdiction in the State of California for any
arbitration contemplated by this Section 33.1. The decision of the arbitrators
                                 ------------
will be binding upon the Parties hereto and all parties claiming under and
through them, and judgment will be entered by any court of competent
jurisdiction. The fees and expenses of the arbitrator will be paid equally by
the Parties.

        33.2  With respect to actions for injunctive relief and specific
performance, the Parties submit to the jurisdiction of any state or federal
court sitting in Los Angeles County in any Action arising out or respecting this
Agreement and agree that all claims in respect of such Action shall be heard and
determined in any such court. The Parties waive any defense of inconvenient
forum to the maintenance of any Action and waive any bond, surety or other
security that may be required of any other party with respect to the Action. The
Parties agree that a final judgment in any Action brought under this Section
                                                                     -------
33.2 will be conclusive. Either Party may seek injunctive relief if any
----
provision of this Agreement is not performed in accordance with its terms and
for which such Party would not have an adequate remedy for money damages. Any
such remedy will be in addition to any other remedy that may be available at law
or equity.

<PAGE>

        34. Counterparts. This Agreement may be executed in separate
            ------------
counterparts, each of which will be deemed to be an original, but which together
will constitute one and the same instrument.

        IN WITNESS WHEREOF, the Parties have executed this Agreement as of the
date first above written.

                              AMERICAN BIOSCIENCE, INC.,
                              a California corporation

                              By: /s/ Patrick Soon-Shiong
                                  -----------------------
                                    Patrick Soon-Shiong
                                    President

                              AMERICAN PHARMACEUTICAL PARTNERS, INC.,
                              a California corporation

                              By: /s/ Jeffrey M. Yordon
                                  ---------------------
                                    Jeffrey M. Yordon
                                    Chief Operating Officer

<PAGE>

                                   EXHIBIT A

                                  ABI Patents
                                  -----------

                                     [***]

<PAGE>

                                   EXHIBIT B

                                 ABI Insurance
                                 -------------

                 $25,000,000 per incident and in the aggregate

<PAGE>

                                   EXHIBIT C

                                 APP Insurance
                                 -------------

                 $25,000,000 per incident and in the aggregate<PAGE>

                                                                  Execution Copy
                                                                  --------------

                            MANUFACTURING AGREEMENT
                            -----------------------

     THIS MANUFACTURING AGREEMENT (this "Agreement") is made by and between
                                         ---------
AMERICAN BIOSCIENCE, INC., a California corporation ("ABI"), and AMERICAN
                                                      ---
PHARMACEUTICAL PARTNERS, INC., a California corporation ("APP") as of this 20th
                                                          ---
day of November 2001 (the "Effective Date").
                           --------------

                                    RECITALS
                                    --------

A.  ABI has developed and owns the rights to the Product, as defined in Section
                                                                        -------
2.25.
-----

B.  APP has the capability of, and has constructed facilities and equipment
designed for and capable of, manufacturing the Product, and APP desires to
manufacture the Product, or have the Product manufactured upon the terms and
conditions contained herein.

                                   AGREEMENT
                                   ---------

     NOW, THEREFORE, in consideration of the above Recitals, the mutual
covenants and agreements contained herein, and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
Parties hereto hereby agree as follows:

1.  Incorporation of Recitals.  The foregoing recitals are hereby incorporated
    -------------------------
herein as representations and warranties of the Parties hereto.

2.  Definitions.  For purposes of this Agreement, in addition to other defined
    -----------
terms set forth in this Agreement, the terms set forth below will have the
following meanings:

     2.1 "ABI Parties" means ABI, its Affiliates, its permitted assignees and
          -----------
any other party approved in writing by ABI.

     2.2 "Act" means the Federal Food Drug and Cosmetic Act (21 U.S.C. Section
          ---
301 et. seq.) as amended from time to time.

     2.3 "Action" means any actual or threatened claim, suit, arbitration,
          ------
hearing, inquiry, proceeding, complaint, charge or investigation by or before
any court, government, governmental entity or arbitrator.

     2.4 "Affiliate" means any entity controlling, controlled by or under the
          ---------
common control of APP or ABI, as the case may be. Such entity will be considered
an Affiliate only for the time during which such control exists. For the purpose
of this Agreement, "control" means having, directly or indirectly, the power to
direct or cause the direction of management and policies of such entity. FOR
PURPOSES OF THIS AGREEMENT, APP SHALL NOT BE CONSIDERED AN AFFILIATE OF ABI, AND
ABI SHALL NOT BE CONSIDERED AN AFFILIATE OF APP.

     2.5 [***]

[***] Omitted pursuant to a confidential treatment request. The material has
      been filed separately with the Securities and Exchange Commission.

<PAGE>

     2.6 "APP Parties" or "APP Party" means any of APP, its Affiliates and its
          -----------      ---------
permitted assignees.

     2.7 "APP Standard Manufacturing Costs" means direct and indirect costs,
          --------------------------------
including, without limitation the materials, components, raw materials, labor
and overhead, attributable to production, manufacturing, processing, quality
control, and packaging of the Product.  APP Standard Manufacturing Costs will
not include costs incurred in connection with Bad Batches of the Product, nor
will it include general and administrative expenses.  APP Standard Manufacturing
Costs will be updated at the end of each calendar year for the purpose of
determining the price for the succeeding year.  Except as otherwise contemplated
by this definition or as agreed by the Parties, the APP Standard Manufacturing
Costs will be determined in accordance with GAAP and standard costing principles
as currently practiced by APP.

     2.8 "Bad Batches" means batches of Product, other than those referred to
          -----------
in Section 8.2, which either (i) are lost in production; (ii) are determined by
   -----------
final decision of APP's quality group to be not suitable for final release; or
(iii) or are properly rejected by the ABI Parties under Section 9 of this
                                                        ---------
Manufacturing Agreement.

     2.9 "CGMP(s)" means current good manufacturing practices established under
          -------
the Act and the Regulations.

     2.10 "Chemical Ingredients" means paclitaxel and albumin.
           --------------------

     2.11 "Commercially Reasonable Best Efforts" means the commercially
           ------------------------------------
reasonable efforts that a prudent business person or company would expend in the
normal course of its business to accomplish an important objective, but does not
mean efforts that could, if carried out, have a significant negative impact on
the Party's relevant business unit as a whole.

     2.12 "Competitor"  means a business entity that markets and sells a
           ----------
pharmaceutical product that includes taxanes as an active pharmaceutical
ingredient.

     2.13 "Damages" means any and all losses, liabilities, obligations, costs,
           -------
expenses, damages or judgments of any kind or nature whatsoever (including
reasonable attorneys', accountants' and experts' fees, disbursements of counsel
and other costs and expenses incurred in pursuing or defending claims under this
Agreement.

     2.14 "Effective Date" shall mean the date of this Agreement, as set forth
           --------------
above.

     2.15 "Estimated Purchase Plan" means ABI's estimate of the Product to be
           -----------------------
ordered for the Territory, with the exception of North America for so long as
the License Agreement is in effect, for each rolling 12-month period during the
Term, which estimate will be issued on a monthly basis.

     2.16 "FDA" means the United States Food and Drug Administration or any
           ---
other successor agency whose approval is necessary to market the Product in the
United States and any comparable agency in such other countries in the Territory
where ABI intends to obtain regulatory approval.

<PAGE>

     2.17 "GAAP" means generally accepted accounting practices as in effect in
           ----
the United States applied on a basis consistent with past practice.

     2.18 "Legal Requirement" means any statute, law, ordinance, rule,
           -----------------
regulation, permit, order, writ, judgment, injunction, decree or award issued,
enacted or promulgated by any governmental entity or any arbitrator.

     2.19 "License Agreement" means that certain License Agreement entered into
           -----------------
between ABI and APP dated the same date as this Agreement.

     2.20 "Manufacturing Recall" means a Recall arising from or relating to the
           --------------------
Product that, when manufactured by APP, was adulterated, contaminated or was
otherwise caused by APP's failure to comply with this Agreement of the
Specifications set forth in this Agreement.

     2.21 "NDA" means one or more of the New Drug Applications that ABI files
           ---
for the Product with the FDA, including any supplements or amendments and
510(k)s, and any foreign equivalents.

     2.22 "North America" means the countries of the United States and its
           -------------
territories and possessions, Canada and Mexico.

     2.23 "Parties" means APP and ABI ("Party" meaning one of the Parties).
           -------                      -----

     2.24 "Person" means any natural person, corporation, trust, association,
           ------
company, partnership, joint venture, governmental entity or other entity.

     2.25 "Product" means ABI-007, a cremaphor-free, nano-particle paclitaxel
           -------
formulation [***].

     2.26 "Product Liability Claim" means any Action by a third party and any
           -----------------------
appeal from any Action asserted by a third party with respect to the Product
alleging product liability, product defect, design, manufacturing, packaging or
labeling defect, failure to warn, or any similar action relating to the
formulation, manufacture, use or safety of the Product.

     2.27 "Proprietary Information" means information relating to the Product,
           -----------------------
the properties, composition or structure of the Product or the manufacture or
processing of the Product or the machines used to manufacture or process the
Product or to a Party's business (including, without limitation, reagents,
computer programs, algorithms, names and expertise of employees and consultants,
know-how, formulas, processes, ideas, inventions, whether patentable or not,
schematics and other technical, business, financial, customer and product
development plans, forecasts, strategies and information), whether previously,
currently or subsequently disclosed to the other Party. Technology and
improvements made by or for ABI will be considered Proprietary Information of
ABI. ABI's Proprietary Information shall include ABI Owned Developments. APP's
Proprietary Information shall include APP Owned Developments.

     2.28 "Proprietary Rights" means any and all patent rights, copyrights,
           ------------------
maskwork, trade secret rights and all other intellectual and industrial property
rights.

<PAGE>

     2.29 "Purchase Order" means written orders for the Product issued by any
           --------------
ABI Party and placed with APP.

     2.30 "Regulatory Approval" means (A) with respect to the APP Parties, the
           -------------------
procurement of any registration, permit and approval required by applicable
government authorities for the manufacture of the Product in the Territory, and
(B) with respect to ABI, the procurement of any registration, permit and
approval required by applicable government authorities for the importation,
marketing, sale, distribution, and use with respect to clinical trials of the
Product in the Territory.

     2.31 "Regulations" means the regulations made under the Act, including
           -----------
without limitation those regulations currently contained in Title 21 of the Code
of Federal Regulations, as amended from time to time.

     2.32 "Specifications" means the specifications for the Product and
           --------------
contained active pharmaceutical ingredients, raw materials, components and
packaging, along with manufacturing procedures for the Product, all of which are
set by ABI considering the comments of APP, as may be changed from time to time
by mutual agreement of the Parties. The Specifications in effect as of the
Effective Date are set forth in a document separately counter-signed by both
Parties. The Specifications include without limitation:

           (A) raw material specifications (including approved suppliers,
     proofs, chemical, microbiological and packaging specifications);

           (B) sampling requirements (including lab, chemical and
     microbiological);

           (C) compounding module, including compounding process and major
     equipment;

           (D) intermediate specifications;

           (E) finished Product release criteria;

           (F) stability specifications;

           (G) test methods; and

           (H) packaging, labels and labeling.

     2.33 "Technology" means any and all ideas, techniques, inventions, methods,
           ----------
data, information, formulae, processes, trade secrets, intellectual property,
know-how, and test results, whether patentable or not, and whether or not
reduced to practice, including Proprietary Rights, owned, controlled or
otherwise in possession of or used by ABI as of the date of this Agreement, or
during the term of this Agreement and necessary or useful to make, have made,
develop, have developed, use, import, market, offer for sale or sell the
Product.

     2.34 "Term" means the initial Term (as defined in Section 12) and any
           ----
Extension or Extensions (as defined in Section 12) to the initial term.
                                       ----------

<PAGE>

     2.35 "Territory" means the entire world.
           ---------

3.  Manufacture and Supply.
    ----------------------

     3.1 Subject to the terms, conditions and provisions of this Agreement, APP
hereby covenants and agrees that during the Term it will manufacture and sell
the Product to the ABI Parties as required by the ABI Parties for resale in the
Territory, with the exception of North America to the extent the Product is
licensed to APP pursuant to the License Agreement, and, for as long as APP
complies with its obligations under this Agreement, ABI hereby grants APP:

           (A) the exclusive right to manufacture the Product for resale in
     North America for a period of three years, after which time such right will
     be non-exclusive for the remainder of the Term; and

           (B) a non-exclusive right to manufacture the Product for resale in
     the remainder of the Territory.

           (C) Notwithstanding Section 3.1(A), in the event APP fails to make a
                               --------------
     milestone payment pursuant to the terms of Section 9 of the License
     Agreement for one or more indications, APP's license to manufacture the
     Product for that indication related to the declined milestone payment shall
     become non-exclusive.

     3.2 Notwithstanding Section 3.1, APP's obligation to sell the Product to
parties that ABI approves in writing, will be subject to APP applying reasonable
credit standards consistent with APP's standard practice.

     3.3 APP will manufacture the Product solely for (A) the ABI Parties and (B)
the APP Parties so long as the License Agreement remains in effect. If there are
shortages of Chemical Ingredients (as defined in Section 5) or if capacity
                                                 ---------
limitations of the APP facilit(ies) indirectly or directly lead to a shortage in
the supply of manufactured Product, a fraction of the total manufactured Product
will be allocated by APP to each of the ABI Parties and to the APP Parties (each
a "Distributor") as follows:
   -----------

           (A)  [***]

           (B)  [***]

                (1)  [***]

                (2)  [***]

                (3)  [***]

                (4)  [***]

     3.4 APP will:

<PAGE>

           (A) obtain and maintain such approvals and licenses as may be
     required for the manufacture of the Product for commercial sale in the
     Territory;

           (B) have such facilities, resources, and personnel, and such industry
     expertise, as may be required for it to manufacture such quantities of the
     Product as may be required hereunder;

           (C) manufacture, test, supply, package, store, ship, deliver, and
     otherwise handle the Product in compliance with the terms and conditions of
     this Agreement, the Specifications, cGMPs, the Act, the Regulations, the
     rules and regulations of the FDA, applicable NDAs and any and all other
     applicable Legal Requirements, including any and all approvals required for
     the manufacture of the Product after FDA approval is obtained;

           (D) set batch sizes in accordance with relevant economic factors and
     APP's standard manufacturing practice;

           (E) keep true, accurate and complete books, records, reports and
     accounts in connection with or relative to the Product, and the
     manufacturing, testing, production, supply, packaging, storage, shipment,
     delivery and handling of the Product, as well as any other books and
     records as may be required from time to time by applicable law, rules and
     regulations; and

           (F) as requested by ABI, provide reasonable warehousing, distribution
     and transportation functions with respect to the Product on behalf the ABI
     Parties and ABI will reimburse APP for APP Internal Costs with respect to
     such activities performed on ABI's behalf as requested by ABI.

     3.5 Subject to the provisions in the License Agreement, ABI will be solely
responsible for obtaining any Regulatory Approvals relating to the marketing of
the Product purchased by the ABI Parties under this Agreement, including but not
limited to, drug approval applications.

     3.6 ABI, or any designee of ABI, will have the right at any time upon prior
reasonable notice and during regular business hours to inspect and examine APP's
facility(ies) used in connection with and relative to the Product and the
manufacturing, testing, supply, packaging, storage, shipment, delivery or
handling of the Product. To minimize disruption to APP's normal operations,
neither ABI nor its designee may perform more than one such audit per facility
per calendar year. If a facilities audit reveals a material manufacturing
problem, ABI will have the right to re-inspect and examine APP's facilities
twice in the following 12-month period.

     3.7 ABI will have the right, in conjunction with any manufacturing audit,
to audit and inspect any and all documents and records related directly to (A)
APP's manufacture and supply of the Product, and (B) APP's performance under
this Agreement with respect to the manufacture and supply of the Product. APP
will also permit representatives of any governmental authority in the Territory,
including, but not limited to, the FDA or its agents to visit and inspect any
and all facilities used in the manufacturing, testing, processing, packaging, or
shipping of the Product. This right for ABI and the FDA includes access to audit
any and all documents and records relating to APP's performance under this
Agreement.

<PAGE>

     3.8 Prior to commencing manufacturing any batch of the Product, APP will
designate whether the batch is being manufactured for the ABI Parties or for the
APP Parties.

     3.9 Except to the extent otherwise provided in this Agreement, APP will not
give any more favorable treatment to itself than it does to the ABI Parties with
respect to the Product.

4.  Transfer of Technology; Improvements.  ABI will convey and disclose in
    ------------------------------------
tangible form to APP, as soon as reasonably practicable after the Effective Date
and throughout the term of this Agreement, all Technology.  Each Party agrees to
as soon as reasonably practicable promptly disclose in tangible form to the
other Party all modifications and improvements made to the Technology during the
term of this Agreement.  APP will immediately transfer to ABI all right, title
and interest in and to any process, product, composition, or product-by-process,
or any improvements thereto, including inventions ("Developments"), made by the
APP Parties using ABI's processes or outputs ("Processes") (collectively, the
"ABI Owned Developments"). From and after their development, the ABI Owned
Developments will be included within the scope of the license granted to APP
under this Agreement. APP will own any Developments made by APP or its assignees
using any process or output other than the Processes, provided such Developments
are developed solely by APP or its assignees without any input from ABI or any
of its employees, including Patrick Soon-Shiong. Any Developments that are
developed solely by APP without using any Processes are referred to as the "APP
Owned Developments." APP may take whatever steps it deems necessary to protect
its rights in the APP Owned Developments.  APP further grants to ABI, subject to
Section 12.7, a perpetual, royalty-free license to use all of the APP Owned
------------
Developments that are used or needed by APP in the manufacture or
commercialization of the Product.

5.  Chemical Ingredients.  Promptly following the Effective Date, ABI will use
    --------------------
and continue to use commercially reasonable efforts to identify at least two
suppliers of each Chemical Ingredient that have obtained or that ABI reasonably
believes will seek and obtain FDA approval, and shall diligently seek approval
as part of its NDA to use such sources. APP will exclusively order and purchase
all Chemical Ingredients used by APP to manufacture the Product for itself or
for the ABI Parties from those sources.

6.  Orders.  By the end of the first week of each month of the Term, ABI will
    ------
send APP an Estimated Purchase Plan behalf of the ABI Parties.  The Parties
acknowledge and agree that the Estimated Purchase Plan is an estimate only and
is not binding upon ABI, except that the Estimated Purchase Plan for the next
three months will become binding on both Parties.  APP shall not be obligated to
supply any quantity of Product earlier than 90 days following the placement of
the Purchase Order for such Product.  APP will use Commercially Reasonable Best
Efforts to fulfill any Purchase Order for the Product but will not be obligated
to fill any Purchase Orders for the Product that in the aggregate exceed the
amounts supplied in the previous full calendar year by more than 15%.  If the
demand for the Product is believed to be greater than the 15% annual increase
contemplated by this Section 6, the Parties will use their best efforts to reach
                     ---------
agreement with respect to the capacity requirements that APP must provide to
fulfill such requirements and the amount of time APP will have to increase its
capacity to meet the increased requirements.  ABI shall give APP written notice
no later than 18 months before the ABI Parties contemplate selling the Product
outside North America.  At such time, ABI shall estimate the quantity of Product
ABI believes it will need in the 12 months following launch in such territory

<PAGE>

and will update that estimate no less often than every six months.  Upon
commencement of sales in such territory, the estimates shall be included in the
Estimated Purchase Plan.

7.  Price and Payment.
    -----------------

     7.1 With the issuance by ABI Parties of a Purchase Order, ABI shall
designate whether (and, as applicable, what portion of) the ordered Product
shall be used for clinical trials or commercial sale. The price per unit of
Product to be charged to the ABI Parties by APP for use in clinical trials will
be [***]. The price per unit of Product to be charged to the ABI Parties by APP
for commercial sale shall be [***]. APP shall purchase all Chemical Ingredients
for Product sold to ABI Parties for clinical trial use. APP shall order, but ABI
shall pay for, all Chemical Ingredients for Product for commercial sale by ABI
Parties. The prices and delivery of the Product will be made Ex-Works at APP's
manufacturing site.

     7.2 The APP Standard Manufacturing Costs will be subject to an adjustment
at the end of each calendar year that this Agreement is in effect for the next
calendar year to account for any cost increases or cost decreases (which must be
reasonably documented by APP to ABI) in any of the components of the cost with
the exception of Chemical Ingredients. APP will be entitled at any time during
the Term to increase the Non-Commercial Price to account for increases, and
shall decrease the Non-Commercial Price to account for decreases, (which must be
reasonably documented by APP to ABI) in the cost of Chemical Ingredients.

     7.3 APP will issue an invoice to the relevant ABI Party for each Purchase
Order, based upon and reflecting the applicable price.  Invoices will be issued
upon release of the Product and payment must be made, net 30 days after receipt
by the relevant ABI Party of an invoice, so long as each Purchase Order and
invoice complies with the terms and conditions of this Agreement.
Notwithstanding the foregoing, if any order of the Product is shipped in advance
of its original requested shipping date, APP will not invoice for that order
until its original requested shipping date.

     7.4 APP will look solely to the party issuing the Purchase Order for
payment but, subject to Section 9, if an ABI Party fails to pay APP within
                        ---------
thirty days of receipt of an invoice, APP will not be obligated to ship any more
Product to that ABI Party until the invoice is paid in full.

     7.5 The Parties agree to handle the costs associated with Bad Batches of
the Product manufactured for ABI Parties as follows:

           (A)  [***].

           (B)  [***].

           (C)  [***].

           (D)  [***].

8.  ABI Regulatory Filings.
    ----------------------

<PAGE>

     8.1 APP will reasonably cooperate with ABI with respect to (A) all filings
and other submissions made by ABI with the applicable governmental agency,
department or other body regarding or relating to the Product and (B) ABI's
efforts to obtain all Regulatory Approvals to develop, test, market, and
distribute the Product in the Territory. Without limiting the foregoing, APP
will provide ABI with such data monitoring support and data analysis support
related to manufacturing issues as ABI may reasonably request. All data and
information relating to such support will be the property of ABI and may be used
by ABI, at no cost to ABI, in such manner as ABI determines.

     8.2 In any Territory where the ABI Parties are selling and marketing the
Product, APP will prepare and submit a chemistry, manufacturing and controls
(CMC) section to any regulatory agency as reasonably requested by ABI, or
analogous section in various countries. Notwithstanding anything to the contrary
in this Section, such CMC will be owned by and will be the Proprietary
Information of ABI. Subject to the provisions of, and during the pendency of,
the License Agreement, the cost of any Batches manufactured by APP for
Regulatory Approval in North America shall be shared equally by the Parties. Any
Batches manufactured by APP for Regulatory Approval outside of North America
shall be bought and paid for by ABI at APP Standard Manufacturing Cost.

     8.3 If either Party becomes aware of any product or activity of any third
party that involves or may involve infringement or other violation of any
Technology, that Party must promptly notify the other Party in writing of the
infringement or violation. ABI may in its discretion take or not take whatever
action it believes is appropriate. APP will fully cooperate with ABI with
respect to bringing any action, including joining as a party to the suit, if
necessary, supplying essential documentary evidence and making essential
witnesses then in its employ available.

9.  Rejected Product.
    ----------------

     9.1 The relevant ABI Party will inspect each lot of the Product for
compliance with the Specifications upon receipt. If within 60 days after receipt
of the Product the ABI Party notifies APP in writing that it does not meet the
Specifications as determined by the ABI Party's testing and inspection of the
Products, APP will replace the Product, subject to Section 9.2, at APP's expense
                                                   -----------
within 45 days of such notice. APP will pay for shipping charges to deliver such
replacement Products to ABI or its designee.

     9.2 If APP disputes the ABI Party's rejection of all or part of any
shipment of the Product as set forth in Section 9.1, it will notify the ABI
                                        -----------
Party in writing within 10 days of receipt of ABI's rejection notice. If such
dispute is not resolved by mutual agreement of the Parties within 60 days of the
ABI Party's notice, such dispute will be resolved by an independent, FDA-
approved testing organization or consultant of recognized repute within the U.S.
pharmaceutical industry, to be mutually designated by the Parties, the
designation of which will not be unreasonably withheld or delayed by either
Party. The determination by the testing entity of the Products' material
compliance or material non-compliance with the Specifications will be final and
binding upon the Parties. The fees and expenses of the testing entity making the
determination will be paid by the Party against which the determination is made.
If the testing entity determines that part or all of the shipment does not
materially comply with the

<PAGE>

Specifications, APP will, at the relevant ABI Party's election, replace the
Product at APP's expense or credit amounts already paid by the ABI Party within
30 days of such determination.

10.  Adverse Experience Reporting; Recalls.
     -------------------------------------

     10.1 Each Party will report to the other Party any information of which it
becomes aware concerning any adverse drug experience in connection with the use
of the Product, including the incidence and the severity thereof.  ABI will
provide to APP copies of any reports submitted to the FDA relating to any
adverse drug experiences that ABI determines to be significant.

     10.2 If ABI is required to initiate, or otherwise in its discretion decides
to initiate, a recall, withdrawal or field correction (collectively, a "Recall")
                                                                        ------
of the Product in the Territory, ABI will notify APP and provide a copy of its
proposal with respect to such Recall, including the Recall letter, for APP's
review prior to ABI's initiation of the Recall. If APP independently believes
that a Recall of the Product in the Territory may be necessary or appropriate,
it must notify ABI, and the parties must fully cooperate with each other
concerning the necessity and nature of the Action.

     10.3 ABI will be responsible for all Recall activities with respect to
Recall of the Product. APP will reasonably cooperate with ABI in connection with
any Recall. Each Party will maintain complete and accurate Recall records
relating to the Product for any periods that are required by any Legal
Requirement.

     10.4 The fees, costs and expenses of any Recall (collectively, the "Recall
                                                                         ------
Expenses") of the Product will be apportioned between the Parties as follows:
--------

           (A) Except as provided in Section 10.4(C)ABI will pay all Recall
     Expenses related to Recalls of the Product sold by ABI Parties.

           (B) Except as provided in Section 10.4(C) the Parties shall share
     50%/50% all Recall Expenses related to Recalls of the Product sold by the
     APP Parties in the Territory;

           (C) If the Recall is a Manufacturing Recall as determined by an
     independent third party, then APP will pay all Recall Expenses.

11.  Product Liability.
     -----------------

     11.1 For so long as ABI is conducting clinical trials of the Product or
commercially marketing and selling the Product, it must maintain product
liability insurance with respect to the Product, with a reputable carrier, in
the amounts set forth in Exhibit A, naming APP and its Affiliates as additional
                         ---------
insureds.

     11.2 For so long as APP is manufacturing and selling the Product, it must
maintain product liability insurance with respect to the Product, with a
reputable carrier, in the amounts set forth in Exhibit B hereto, naming ABI and
                                               ---------
its Affiliates as additional insureds.

<PAGE>

     11.3 Each Party must notify the other Party as promptly as practicable if a
Product Liability Claim is commenced or threatened against any Party. Each Party
must cooperate with the other Party in connection with any Product Liability
Claim that is commenced or threatened against the other Party.

     11.4 If a Product Liability Claim is asserted against both Parties, each
such Party will have the right to designate counsel to defend itself in such
Product Liability Claim. If a Product Liability Claim is brought against one
Party but not the other Party, the named Party will (subject to Section 11.5)
                                                                ------------
have absolute control of litigation, except that:

           (A) the other Party may appoint counsel to participate in the defense
     of such Product Liability Claim if the named Party reasonably determines
     that the participation would not adversely affect the Attorney-Client
     Privilege; and

           (B) if the litigation could reasonably be expected to have an adverse
     effect on the development and commercialization of the Product, the named
     Party will consult with the other Party regarding the conduct of the
     litigation if the named Party reasonably determines that the cooperation
     would not adversely affect the attorney-client privilege.

     11.5 Neither Party shall agree to a settlement of any Product Liability
Claim without the consent of the other Party, which consent may not be
unreasonably withheld or delayed, if the settlement:

           (A) would have an adverse effect on the development or
     commercialization of the Product; or

           (B) would otherwise have a material adverse effect on the other
     Party.

     11.6 Each Party will be solely responsible for any Damages payable by such
Party following final judgment or settlement of any Product Liability Claim
arising from use or sales of the Product in North America (collectively,
"Product Liability Costs") that arise directly from or relate directly to the
 -----------------------
gross negligence, fraud or intentional misconduct of that Party, and must
promptly pay or reimburse the other Party if the other Party pays or incurs any
Product Liability Costs.

12.  Term and Termination.
     --------------------

     12.1 This Agreement will commence on the Effective Date and will terminate
on the 10th anniversary hereof (the "Initial Term"). ABI may extend this
                                     ------------
Agreement after the Initial Term for successive two-year terms (an "Extension")
                                                                    ---------
by giving APP written notice of its election to extend this Agreement six months
prior to the termination of the Initial Term of any Extension.

     12.2 The non-defaulting Party may immediately terminate this Agreement if
the other Party:

           (A) commits a material breach or default ("Breach") under this
     Agreement, which Breach is not remedied within 60 days after the receipt of
     written notice of the Breach by the

<PAGE>

     Party in Breach (except as to the payment of money by ABI, for which the
     notice period will be 10 days). Notwithstanding the foregoing, if the
     Breach is not curable in 60 days, and the breaching or defaulting party in
     good faith notifies the other Party in writing prior to the 60 days that it
     is initiating cure of the Breach, and initiates cure of such Breach within
     60 days and in good faith continues to attempt to cure the Breach, then
     this Agreement shall not be terminated pursuant to this Section 12.2(A);
                                                             ----------------

           (B) has made a material misrepresentation of any representation or
     warranty contained in this Agreement;

           (C) has a permanent or temporary restraining order, preliminary
     injunction or other order granted against it by a court or authority
     enjoining or restricting the manufacture and/or distribution of the Product
     as contemplated hereby in the Territory. Notwithstanding the foregoing, if
     any such order results or would foreseeably result in a decline of 10% or
     less of units of Product manufactured by APP as compared to the prior
     calendar year's number of units of Product manufactured by APP, then this
     Agreement shall not be terminated pursuant to this Section 12.2(C).

           (D) The right of a Party to terminate this Agreement provided in this
     Section 12.2 will not be affected in any way by its waiver of, or failure
     ------------
     to take such action with respect to, any previous default.

     12.3 In addition to its right to terminate this Agreement, if APP fails to
supply the Estimated Purchase Plan Requirements, ABI may, at its option, choose
to make this Agreement non-exclusive.

     12.4 Following a 60-day period after written notice to cure such
condition, this Agreement may be terminated by either ABI or APP if the other
Party:

           (A) does not pay its debts generally as they become due, or is unable
     to pay its debts generally as they become due;

           (B) has or has instituted against it any proceeding seeking to
     adjudicate it bankrupt or insolvent, or seeking liquidation, winding up,
     reorganization, arrangement, adjustment, protection, relief or composition
     of it or its debts under any law relating to bankruptcy, insolvency or
     reorganization or relief of debtors;

           (C) makes a general assignment for the benefit of creditors;

           (D) seeks the entry of an order for relief or the appointment of a
     receiver, liquidator, sequestrator, trustee, custodian or similar official
     for it; or

           (E) takes advantage of any other law or procedure for the protection
     of creditors.

     12.5 Termination is not the sole remedy under this Agreement, and whether
or not termination is effected, all other remedies remain available to each
Party.

<PAGE>

     12.6  If ABI terminates the License Agreement, ABI will have the right, at
its option, to terminate this Agreement.

     12.7  Upon termination by APP under Section 12.2 or 12.4, ABI's license to
                                         ------- ----    ----
APP Owned Developments shall also terminate.

13.  Confidentiality.
     ---------------

     13.1  Each Party recognizes that the other Party holds its Proprietary
Information as important.  In particular, each Party recognizes that the other
Party's Proprietary Information (and the confidential nature thereof) is
critical to the other Party's business and that neither Party would enter into
this Agreement without assurance that such information and the value thereof
will be protected as provided in this Section 13 and elsewhere in this
                                      ----------
Agreement.

     13.2  Each Party must, therefore:

           (A)  Hold the other Party's Proprietary Information in confidence and
take reasonable precautions to protect the Proprietary Information (including,
without limitation, no less than all precautions that it employs with respect to
its own confidential materials);

           (B)  not divulge (except pursuant to a sublicense expressly
authorized in this Agreement) the other Party's Proprietary Information or any
information derived therefrom to any third person; and

           (C)  not make any use whatsoever at any time of the other Party's
Proprietary Information except for purposes of and expressly authorized in this
Agreement.

     13.3  Any employee given access to any Proprietary Information must have a
legitimate "need to know" and must be bound in writing to maintain the
confidence of information to which it is given access.

     13.4  Without granting any right or license, the disclosing Party agrees
that the foregoing restrictions will not apply with respect to information that
the receiving Party is able to demonstrate by competent evidence:

           (A)  is in or (through no improper action or inaction by the
receiving Party or any Affiliate of the receiving Party or its agents or
employees) enters the public domain (and is readily available without
substantial effort);

           (B)  was rightfully disclosed to it by another person without
restriction; or

           (C)  was independently developed by it by persons without access to
such information and without use of any of the disclosing Party's Proprietary
Information.

     13.5  Each Party's obligations under this Section 13 will terminate five
                                               ----------
years after the date of termination or expiration of this Agreement. The Parties
recognize and acknowledge that prior to the Effective Date of this Agreement,
each Party has received the other Party's

<PAGE>

Proprietary Information and each hereby agrees to protect the Proprietary
Information to the same extent as set forth in this Section 13.
                                                    ----------

     13.6  Immediately upon termination or expiration of this Agreement, each
Party will turn over to the other Party all Proprietary Information of the other
Party and all documents or media containing any Proprietary Information and any
and all copies or extracts thereof.

     13.7  Each Party acknowledges and agrees that due to the unique nature of
Proprietary Information, there can be no adequate remedy at law for any breach
of each Party's obligations under this Section 13, that any breach may result in
                                       ----------
irreparable harm to the disclosing Party, and therefore, that upon any breach or
any threat of breach, the disclosing Party will be entitled to appropriate
equitable relief (without the posting of any bond) in addition to whatever
remedies it might have at law in connection with any breach or enforcement of
the receiving Party's obligations under this Agreement or the unauthorized use
or release of any Proprietary Information.

14.  Use of Brand Names.
     ------------------

     14.1  APP has the right and license to use any brand name included in an
NDA that is approved by the FDA for the Product ("ABI Brand Names") in
                                                  ---------------
connection with labeling the Product manufactured by APP under this Agreement
and other related manufacturing procedures. Any use by APP of ABI Brand Names
will be subject to ABI's prior approval.

     14.2  In connection with its use of ABI Brand Names, APP must:

           (A)  not take any action (or refrain from taking any action) that
could impair or dilute the value of any ABI Brand Names; and

           (B)  reasonably cooperate with ABI in connection with any Action
relating to the use by ABI (or its licensees, including APP) of any ABI Brand
Names that APP is using.

15.  Indemnification; Incidental And Consequential Damages.
     -----------------------------------------------------

     15.1  APP agrees to indemnify, defend and hold harmless the ABI Parties
from any Damages incurred by or assessed against the ABI Parties resulting from
a third party claim caused by or alleged to be caused by:

           (A)  APP's failure to perform any of its obligations under this
Agreement;

           (B)  any breach of or inaccuracy in any representations or warranty
made by APP in this Agreement;

           (C)  any Product Liability Claim arising from the gross negligence,
fraud or intentional misconduct of APP or any APP Affiliate; and

<PAGE>

           (D)  any Product Liability Claim directly resulting from the use of
the Product that, when manufactured by APP, was adulterated or contaminated, or
was otherwise caused by APP's failure to comply with this Agreement or the
Specifications.

     15.2  ABI agrees to indemnify, defend and hold harmless the APP Parties
from any Damages incurred by or assessed against the APP Parties resulting from
a third party claim caused by or alleged to be caused by:

           (A)  ABI's failure to perform any of its obligations under this
Agreement;

           (B)  any breach of or inaccuracy in any representations or warranty
made by ABI in this Agreement;

           (C)  any Product Liability Claim arising from the gross negligence,
fraud or intentional misconduct of ABI or any ABI Affiliates; and

           (D)  any Product Liability Claim directly resulting from the use
and/or sale of the Product outside North America except for those covered in
Section 15.1(C) or Section 15.1(D).

     15.3  Except with respect to APP Owned Developments and ABI Owned
Developments, ABI further indemnifies APP for any proceedings instituted by or
on behalf of a third party based upon a claim that the manufacture, use or sale
of the Product infringes a patent or any other proprietary right of the third
party. Such indemnification obligation shall be limited as follows:

           (A)  to the extent such proceeding or settlement thereof results in a
future royalty to be paid by APP, ABI's indemnity obligation shall be satisfied
by having such royalty payment be a deduction from Net Sales; and

           (B)  to the extent such proceeding or settlement thereof results in a
payment obligation other than as provided in Section 21.3(A) above, ABI shall
                                             ---------------
indemnify APP only to the extent of fifty percent (50%) of payments previously
made by APP to ABI pursuant to Section 8.1 of the License Agreement, and any
                               -----------
indemnity payments to be made by ABI to APP or on behalf of APP pursuant to the
foregoing shall be limited to fifty percent (50%) of ABI's operating cash flow,
including without limitation, the split of Gross Profits under the License
Agreement.

     15.4  If any Party entitled to be indemnified pursuant to this Section 15
                                                                    ----------
(an "Indemnified Party") receives notice of the assertion by any Person of any
    ------------------
claim or of the commencement by any such Person of any Action (any such claim or
Action being referred to herein as an "Indemnifiable Claim") with respect to
                                       -------------------
which another Party hereto (an "Indemnifying Party") is or may be obligated to
                                ------------------
provide indemnification, the Indemnified Party must promptly notify the
Indemnifying Party in writing (the "Claim Notice").  The failure to provide such
                                    ------------
notice will not relieve or otherwise affect the obligation of the Indemnifying
Party to provide  indemnification hereunder, except to the extent that any
Damages directly resulted or were caused by such failure.

<PAGE>

     15.5  The Indemnifying Party will have 30 days after receipt of the Claim
Notice to undertake, conduct and control, through counsel of its own choosing
and at its expense, the settlement or defense of the claim, and the Indemnified
Party will cooperate with the Indemnifying Party in connection with the
settlement or defense, if:

           (A)  the Indemnifying Party permits the Indemnified Party to
participate in the settlement or defense through counsel chosen by the
Indemnified Party (subject to the consent of the Indemnifying Party, which
consent shall not be unreasonably withheld);

           (B)  the fees and expenses of such counsel will not be borne by the
Indemnifying Party; and

           (C)  the Indemnifying Party does not settle any Indemnifiable Claim
without the Indemnified Party's consent. So long as the Indemnifying Party is
vigorously contesting any Indemnifiable Claim in good faith, the Indemnified
Party may not pay or settle the claim without the Indemnifying Party's consent,
which consent shall not be unreasonably withheld.

     15.6  If the Indemnifying Party does not notify the Indemnified Party
within 30 days after receipt of the Claim Notice that it elects to undertake the
defense of the Indemnifiable Claim described in the Claim Notice, the
Indemnified Party has the right to contest, settle or compromise the
Indemnifiable Claim in the exercise of its reasonable discretion. However, the
Indemnified Party must notify the Indemnifying Party of any compromise or
settlement of any such Indemnifiable Claim.

     15.7  Notwithstanding anything in this Section 15 to the contrary, APP is
                                            ----------
not entitled to assume the defense for any Indemnifiable Claim (and will be
liable for the reasonable fees and expenses incurred by the Indemnified Party in
defending the claim) if the Indemnifiable Claim seeks an order, injunction or
other equitable relief (or other relief for other than money damages) against
ABI or its Affiliates which ABI determines, after conferring with its counsel,
cannot be separated from any related claim for money damages and which, if
successful, would adversely affect the commercialization of the Product.
However, if an equitable relief portion of the Indemnifiable Claim can be
separated from that for money damages, APP may assume the defense of the portion
relating to money damages.

16.  EXCEPT FOR BODILY INJURY OF A PERSON, NEITHER PARTY WILL BE LIABLE
HEREUNDER UNDER ANY CONTRACT, NEGLIGENCE, STRICT LIABILITY OR OTHER LEGAL OR
EQUITABLE THEORY FOR ANY SPECIAL, INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES,
INCLUDING WITHOUT LIMITATION, LOSS OF PROFITS FROM THE USE OF (OR INABILITY TO
USE) THE TECHNOLOGY, THE DEVELOPMENT OR COMMERCIALIZATION OF THE PRODUCT OR
OTHERWISE IN CONNECTION WITH, OR ARISING OUT OF, THIS AGREEMENT.

17.  Miscellaneous Provisions.
     ------------------------

     17.1  Independent Contractors.  ABI and APP are independent parties, and
           -----------------------
nothing contained herein will be construed to create a joint venture,
partnership or similar relationship. Neither Party is authorized to, nor will
it, make any statements, claims, representations,

<PAGE>

warranties or otherwise act in any way so as to incur any liability whatsoever
for which the other Party may become directly, indirectly or contingently
liable.

     17.2  Assignment.

           (A)  The rights and obligations of the Parties under this Agreement
may not be assigned or transferred in any manner, including, without limitation,
by operation of law, sale of stock or sale of assets, without the prior written
approval, which shall not be unreasonably withheld, of the other Party (and any
attempt to do so will be void) except that:

                (1)  rights to payment of money may be assigned without such
approval; and

                (2)  either Party has the right to assign this Agreement to its
lenders as collateral security under a credit facility and following
acceleration of that credit facility, its lender has the right to assign this
Agreement to a third party reasonably satisfactory to the other Party. Despite
the foregoing, in no event will ABI be obligated to consent to an assignment of
this Agreement to a Competitor.

           (B)  Notwithstanding anything to the contrary in Section 17.2(A), if:
                                                            ---------------

                (1)  any Party:

                     (a)  merges or consolidates with any other corporation,
partnership or other business entity; or

                     (b)  has all or substantially all of such Party's business
or assets transferred in any manner to any other corporation, partnership or
other business entity; or

                (2)  any other Person acquires the power, directly or
indirectly, to direct or cause the direction of management and the policies of
such Party (collectively, a "Change of Control");
                             -----------------

such event will be deemed an approved assignment for purposes of this Agreement
if the conditions set forth in Section 17.2(C) are satisfied.
                               ---------------

           (C)  Following a Change of Control, the successor to a Party will
succeed to, and be subject to, all rights, interests, duties and obligations of,
and shall thereafter be deemed for all purposes to be the applicable Party under
this Agreement. To be deemed an approved assignment under this Section 17.2, a
                                                               ------------
successor must:

                (1)  have experience, facilities, capabilities, and financial
resources equal to or greater than such Party; and

                (2)  expressly acknowledge, in a written instrument delivered to
the other Party in a form reasonably acceptable to the Parties the succession to
all duties and obligations of such Party under this Agreement.

<PAGE>

           (D)  Despite the foregoing, for the purposes of this Agreement, an
IPO will not be considered a Change of Control.

     17.3  Notices.  Any and all notices given pursuant to this Agreement shall
           -------
be in writing, and shall be deemed to have been properly given when delivered
personally or sent by facsimile, air courier, or post, to the respective address
shown below or such other address as shall be specified by the Party(ies)
pursuant to written notice given in accordance with this Section 17.3.  Any
                                                         ------------
notice shall be effective upon receipt, which shall be deemed to occur one
business day after the sending of the facsimile is sent, two business days after
the sending by air courier, and five calendar days after the delivery to the US
Postal Service and properly marked and stamped for first class mail, and shall
be sent:

     If to ABI to:

          American BioScience, Inc.
          2730 Wilshire Boulevard
          Santa Monica, California 90403
          Attention:  Chief Executive Officer
          Facsimile:310/998-8553

     With a copy to:

          Attention:
          Facsimile:

     If to APP to:

          American Pharmaceutical Partners, Inc.
          10866 Wilshire Boulevard
          Los Angeles, California 90024
          Attention:  Chief Operating Officer
          Facsimile   310/470-7472

     With a copy to:

          American Pharmaceutical Partners, Inc.
          1101 Perimeter Drive
          Schaumburg, Illinois 60173
          Attention:  General Counsel
          Facsimile   847/413-2670

     17.4  Force Majeure.

           (A)  The obligations of a Party hereunder will be suspended during
the time and to the extent that such Party is prevented from complying therewith
due to any event or circumstances beyond the reasonable control and without the
fault or negligence of the affected

<PAGE>

Party (which circumstance is hereinafter referred to as "Force Majeure"),
                                                         -------------
including but not limited to inevitable accidents, perils of navigation, floods,
fire, storms, earthquakes, lockouts, explosion, hostilities, war (whether
declared or undeclared), acts of terrorism, civil disturbances, order or acts of
any government, whether de jure or de facto or any official purporting to act
under authority of any such government (other than as to regulatory approval),
illegality arising from domestic or foreign laws or regulations, insurrections,
quarantine or custom restrictions (other than due to the action or inaction of
the Party claiming a Force Majeure), damage in factories or warehouses, strikes,
lockouts, or other labor difficulty at the Parties, lack of conveyance,
breakdown of machinery or instruments or other disturbances at the Parties or
their suppliers, shortages or inability to obtain Chemical Ingredients or other
components and raw materials from suppliers, or acts of God or other similar
event beyond the reasonable control of, as the case may be, ABI or APP which
results in hindrance of the performance by the Party of its obligations
hereunder.

           (B)  As soon as possible after being affected by a Force Majeure
circumstance, the affected Party must furnish to the other Party all particulars
of the Force Majeure and the manner in which its performance is thereby
prevented or delayed. The Party whose obligations hereunder have been suspended
will promptly and diligently pursue appropriate action to enable it to lift the
Force Majeure situation, except that Party shall not be obligated to settle any
strike, lockout or other labor difficulty on terms contrary to its wishes.

           (C)  If any Force Majeure circumstance cannot be removed or overcome
within 120 days (or such other period as the Parties mutually agree) from the
date the affected Party first became affected, then the non-affected Party may,
at the expiration of such period, by notice to the affected Party terminate this
Agreement, and neither Party will be liable to the other for damages.

     17.5  Amendment and Waiver.  This Agreement (including the Exhibits hereto)
           --------------------
may be amended, modified, superseded or cancelled, and any other of the terms or
conditions hereof may be modified, only by a written instrument executed by both
Parties or, in the case of a waiver, by the Party waiving compliance. Failure of
either Party at any time or times to require performance of any provision hereof
will in no manner affect the right of such Party at a later time to enforce the
same, and no waiver of any nature, whether by conduct or otherwise, in any one
or more instances, will be deemed to be or considered as a further or continuing
waiver of any provision of this Agreement.

     17.6  Severability.  If any one or more of the agreements, provisions or
           ------------
terms contained herein are declared invalid, illegal or unenforceable in any
respect, the validity of the remaining agreements, provisions or terms contained
will shall in no way be affected, prejudiced or invalidated thereby.

     17.7  Entire Agreement.  This Agreement, together with the Technology Side
           ----------------
Letter, the Exhibits hereto and the separately agreed-upon Specifications,
contains the entire agreement between the Parties, and supersedes any agreements
between them with respect to the subject matter hereof.

<PAGE>

     17.8   Section Headings; Recitals.  The section headings contained in this
            --------------------------
Agreement are for reference purposes only and will not affect in any way the
meaning or interpretation of this Agreement.  The recitals are hereby
incorporated into this Agreement by reference.

     17.9   Governing Law.  This Agreement shall be governed by and construed
            -------------
and enforced in accordance with the substantive law (without regard to conflicts
of law provisions) of the State of California.

     17.10  Arbitration; Equitable Relief.
            -----------------------------

            (A)  Except in the case of a Party seeking equitable relief
hereunder, any and all disputes or controversies, whether of law or fact and of
any kind and nature whatsoever, arising out of or relating to this Agreement,
will be decided by binding arbitration in accordance with Title 9 of the United
States Code and the Commercial Arbitration Rules of the American Arbitration
Association ("AAA"). For claims under $1,000,000 the arbitration will be held
              ---
before a single arbitrator. If the Parties are unable to agree on an arbitrator,
the arbitration will be before an arbitrator selected by AAA. For claims over
$1,000,000 the arbitration will be held before a three-member panel of
arbitrators. If the Parties are unable to agree on a three-member panel of
arbitrators, the arbitration will be before a three-member panel of arbitrators
selected by AAA. Arbitration shall take place in Los Angeles County, State of
California, or such other location as may be agreed by the Parties. Claims with
respect to injunctive relief or specific performance will be resolved by a court
of law in accordance with Section 17.10(B). APP irrevocably consents and submits
                          -----------------
to personal jurisdiction in the State of California for any arbitration
contemplated by this Section 17.10. The decision of the arbitrators will be
                     -------------
binding upon the Parties hereto and all Parties claiming under and through them,
and judgment will be entered by any court of competent jurisdiction. The fees
and expenses of the arbitrator will be paid equally by the Parties.

            (B)  With respect to actions for injunctive relief and specific
performance, the Parties submit to the jurisdiction of any state or federal
court sitting in Los Angeles County in any Action arising out or respecting this
Agreement and agree that all claims in respect of such Action shall be heard and
determined in any such court. The Parties waive any defense of inconvenient
forum to the maintenance of any Action and waive any bond, surety or other
security that may be required of any other Party with respect to the Action. The
Parties agree that a final judgment in any Action brought under this Section
17.10(B) will be conclusive. Either Party may seek injunctive relief if any
-------
provision of this Agreement is not performed in accordance with its terms and
for which such Party would not have an adequate remedy for money damages. Any
such remedy will be in addition to any other remedy that may be available at law
or equity.

     17.11  No Strict Construction.  The language used in this Agreement will be
            ----------------------
deemed to be the language chosen by the Parties hereto to express their mutual
intent, and no rule of strict construction will apply to any term or condition
of this Agreement.

     17.12  Survival.  Except to the extent that any monies are owed and not
            --------
yet paid and for the provisions of Sections 8, 9, 10, 11, 12, 13, 15, 16, 17.3,
                                   ----------  -  --  --  --- --  --  --  ----
17.9, 17.10 and 17.12, none of the provisions herein shall survive Termination.
----  -----     -----

<PAGE>

     17.13  Counterparts.  This Agreement may be executed in separate
            ------------
counterparts, each of which will be deemed to be an original, but which together
will constitute one and the same instrument.

                  [REMAINDER OF PAGE LEFT INTENTIONALLY BLANK]

<PAGE>

     IN WITNESS WHEREOF, the Parties hereto have executed this Agreement as of
the date and year first written above.

                                    AMERICAN BIOSCIENCE, INC.

                                    By:  /s/ Patrick-Soon Shiong
                                         ---------------------------------
                                    Patrick Soon-Shiong
                                    President

                                    AMERICAN PHARMACEUTICAL PARTNERS, INC.

                                    By:  /s/ Jeffrey M. Yordon
                                         ---------------------------------
                                    Jeffrey M. Yordon
                                    Chief Operating Officer

<PAGE>

                                   EXHIBIT A

                                 ABI Insurance

                 $25,000,000 per incident and in the aggregate

<PAGE>

                                   EXHIBIT B

                                 APP Insurance

                 $25,000,000 per incident and in the aggregate

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